bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Brain Volume Increase in Patients with Intracranial Hypertension after Decompressive Craniotomy and Augmentative Craniotomy
Authors: Berra Luigi Valentino , Capobianco Mattia , Cedrone Guido , Bassani Andrea , Santoro Antonio
Published: July 2024

Intracranial hypertension is a critical condition often resulting from traumatic brain injury or malignant middle cerebral artery ischemia, necessitating surgical intervention when conservative treatments fail. This study compares the efficacy of decompressive craniectomy (DC) and augmentative craniotomy (AC) in managing cerebral edema. Sixty-three patients, 52 undergoing DC and 11 undergoing AC, were evaluated for changes in brain volume, midline shift, and other key parameters using pre- and post-operative CT scans. Results indicated that brain volume increased significantly more in the AC group (100 ± 51 cm³) compared to the DC group (72 ± 51 cm³, p < 0.05). Both techniques effectively reduced midline displacement, but AC showed a superior capacity for brain expansion. The findings suggest that AC, which raises the cranial operculum to reduce soft tissue tension and provide hemostatic effects, may offer advantages over DC by allowing greater decompression and reducing the risk of complications such as epidural hematomas. These results support the potential of AC as a promising alternative to DC for treating intracranial hypertension. Future research should investigate long-term outcomes to further validate these findings.
Deformation behavior and formability of AA5052-O aluminum alloy sheet during non-eddy electromagnetic forming
Authors: Liu Wei , Bai Jianghong , Zhang Min , Huang Shangyu
Published: July 2024

Non-eddy electromagnetic forming is a non-traditional electromagnetic forming process by directly imposing the impulse electrical current to the sheet metal instead of inducing the eddy current. The dedicated combinations of specimen and die were designed to represent different strain paths including uniaxial tension, plane strain and equal-biaxial tension. The deformation behaviors of AA5052-O aluminum alloy sheet under different strain paths have been investigated by numerical simulation of coupled electromagnetic-mechanical fields. The limit strains under different strain paths have been experimentally and numerically determined. The Marciniak-Kuczynski theoretical model embedded with the Johnson-Cook strain-rate-dependent hardening model was also to predict the formability. The forming limit curves derived from experiment, simulation, and M-K theoretical model were confirmed to align closely with each other. Compared with quasi-static experiment results, AA5052-O aluminum alloy sheet exhibits improved formability during non-eddy current electromagnetic forming. The limit strains under uniaxial tension, plane strain, and equal-biaxial tension during non-eddy electromagnetic forming increase respectively by about 46%, 42%, and 45%.
Assessment and management of diverse isolates of Colletotrichum falcatum associated with Red Rot disease in sugarcane
Authors: Kurian Jyothi Anna , Jehani Muljibhai , Mohamed Jabril Mukhtar , Vaja Sonal
Published: July 2024

Red rot, a devastating disease affecting sugarcane worldwide, is caused by the pathogen Colletotrichum falcatum. This menace poses a serious threat to sugarcane production, affecting all parts of the sugarcane plant, including leaves, midribs, and stalks. In our comprehensive study, we investigated the morphological, cultural, and pathogenic variability among isolates from midribs and stalks infected with the red rot pathogen. Our research revealed significant variations in mycelium growth among the three isolates from midribs and stalks. These isolates displayed distinct characteristics such as raised fluffy or flat white mycelium growth with light orange pigmentation and a medium to high level of sporulation. The conidia exhibited a falcate shape with an average size of 28.3 µm x 6.75 µm. Pathogenicity was assessed using both the pinprick and plug methods, both of which effectively evaluated disease severity in the CoJ 85 sugarcane variety. An epidemiological investigation highlighted the significant influence of relative humidity on disease development. To combat red rot, we evaluated seven different treatments. Among these, Bavistin, Trichoderma harzianum, and T. viride emerged as the most effective approaches. In addition to fungicides, biocontrol agents have shown promise in managing red rot by targeting C. falcatum and inducing systemic resistance in treated plants.
Formaldehyde dissipation mechanism of active alginate gel and its application in deep air purification
Authors: Lu Zhengxin , Yin Yueran , Gao Zitian , Jiao Quanling , Yang Haorun , Li Gang , Su Yuhong
Published: July 2024

It is very important to purify low level formaldehyde pollution in indoor air by an efficient and low-cost material. In this research, an environmentally friendly material (names as ACA) was prepared by fixing the active component in cactus stem with the three-dimensional network structure of calcium alginate gel. It was observed by a scanning electron microscopy that plant active substances were dispersed and embedded in the three-dimensional network structure gaps of calcium alginate. The large surface area and strong hydrophilicity of the calcium alginate gel indicate a strong ability to capture low level formaldehyde in the airflow, while there is a rapid degradation ability of plant active substances to formaldehyde fix by gel. The prepared material was found an efficient and deep removal ability to formaldehyde in airflow. Results showed that removal rate reached to 88.64 ~ 91.57% at the airflow residence time of 0.13 s and the formaldehyde level in unpurified airflow in the range of 0.081 ~ 0.328 mg·m-3, and the formaldehyde level in purified airflow can below 0.02 mg·m-3. After continuously working for 63 hours, the removal rate was still 64.74 ~ 73.56%, and the formaldehyde level in purified airflow was 0.04 ~ 0.08 mg·m-3. The removal efficiency of ACA-cactus to formaldehyde in airflow was up to 1387.66 mg·h-1·kg-1 (dry weight of gel), and the corresponding maximum airflow purification capacity was 6000 m3·h-1·kg-1. Similar to a bioreactor, enzymatic mild oxidation of plant active components plays a dominant role in the removal of formaldehyde by ACA. This research provides a new idea for the deep purification of formaldehyde in the air and has a huge application potential.
Protocol and preregistration for the CODEC project: Measuring, modelling and mechanistically understanding the nature of cognitive variability in early childhood
Authors: Coolen Ilse E.J.I. , Langen Jordy van , Hofman Sophie , Aagten Fréderique E. van , Schaaf Jessica V. , Michel Lea , Aristodemou Michael , Judd Nicholas , Hout Aran T. B. van , Meeussen Emma , Kievit Rogier A.
Published: July 2024

Background
Children’s cognitive performance fluctuates across multiple timescales. However, fluctuations have often been neglected in favour of research into average cognitive performance, limiting the unique insights into cognitive abilities and development that cognitive variability may afford. Preliminary evidence suggests that greater variability is associated with increased symptoms of neurodevelopmental disorders, and differences in behavioural and neural functioning. The relative dearth of empirical work on variability, historically limited due to a lack of suitable data and quantitative methodology, has left crucial questions unanswered, which the CODEC (COgnitive Dynamics in Early Childhood) study aims to address.
Method
The CODEC cohort is an accelerated 3-year longitudinal study which encompasses 600 7-to-10-year-old children. Each year includes a ‘burst’ week (3 times per day, 5 days per week) of cognitive measurements on five cognitive domains (reasoning, working memory, processing speed, vocabulary, exploration), conducted both in classrooms and at home through experience sampling assessments. We also measure academic outcomes and external factors hypothesised to predict cognitive variability, including sleep, mood, motivation and background noise. A subset of 200 children (CODEC-MRI) are invited for two deep phenotyping sessions (in year 1 & year 3 of the study), including structural and functional magnetic resonance imaging, eye-tracking, parental measurements and questionnaire-based demographic and psychosocial measures. We will quantify developmental differences and changes in variability using Dynamic Structural Equation Modelling, allowing us to simultaneously capture variability and the multilevel structure of trials nested in sessions, days, children and classrooms.
Discussion
CODEC’s unique design allows us to measure variability across a range of different cognitive domains, ages, and temporal resolutions. The deep-phenotyping arm allows us to test hypotheses concerning variability, including the role of mind wandering, strategy exploration, mood, sleep, and brain structure. Due to CODEC’s longitudinal nature, we are able to quantify which measures of variability at baseline predict long-term outcomes. In summary, the CODEC study is a unique longitudinal study combining experience sampling, an accelerated longitudinal ‘burst’ design, deep phenotyping, and cutting-edge statistical methodologies to better understand the nature, causes, and consequences of cognitive variability in children.
Trialregister: ClinicalTrials.gov - NCT06330090
The CPEC is expected to have significant socio-cultural and demographic effects on the local community of Gilgit-Baltistan.
Authors: Ali Basit , Khan Sikandar , Ahmad Shakeel ,   Dr. Haji Ur Rahman4
Published: July 2024

It is expected that the CPEC will transmute the whole society of Pakistan particularly the society of Gilgit-Baltistan as Gilgit-Baltistan is the entranceway of CPEC to Pakistan. All the road networks, communication systems such as fibre optics, as well as gas and oil pipelines, must travel through this area. Aiming at finding the expected socio-cultural and demographic impacts of CPEC on local community of Gilgit-Baltistan. The data from 150 respondents from the local community residing at Gilgit-Baltistan were used for data analysis. Initially the frequency and percentage distribution were checked and then the hypotheses were tested using Chi-square test with SPSS version21. The findings of this research verify that the family and religious institution will have a significant impact of CPEC. CPEC will also bring linguistic and life style changes in Gilgit-Baltistan. It is expected that the CPEC will lead to migration of rural population towards urban areas.
The effect of pre­sowing seed treatment with chlorella suspension on the productivity of different varieties of Triticum aestivum L., T. durum Desf. and T. spelta L.
Authors: Korkhova M. M.
Published: July 2024

Purpose. To determine the main elements of ear productivity, yield and mass fraction of protein in the grain of the studied species and varieties of winter wheat, depending on the pre­sowing treatment of seeds with “Chlorella suspension”. Methods. Field trials with different varieties of winter wheat (T. aestivum, T. spelta and T. durum) were carried out in 2020–2022 at the experimental field of the MNAU’s Educational, Scientific and Practical Centre. Before sowing, the seeds of the varieties studied were treated with the biological preparation “Chlorella suspension”. Results. During the years of research, it was possible to determine the varietal response to weather conditions that influenced the formation of the main elements of winter wheat productivity. For example, the highest number of productive stems (858 pcs/m2) was produced by plants of the variety ‘Vidrada’ (T. aestivum) in the variant with pre­sowing seed treatment with “Chlorella suspension”. In 2020, spelt plants of the ‘Evropa’ variety had the highest grain weight per ear (1.21 g),
but the lowest number of productive stems (435 pcs/m2). ‘Shestopalivka’ (T. aestivum) and ‘Evropa’ (T. spelta) produced the maximum grain yield in 2021 (6.92 and 5.75 t/ha, respectively), ‘Bosfor’ (T. durum) – in 2022 (5.71 t/ha). On average over the three years of the trial, the highest yield was observed in the ‘Shestopalivka’ soft winter wheat plants in the variant with pre­sowing seed treatment with “Chlorella suspension” – 6.01 t/ha, which is 0.22–2.48 t/ha more than in other variants of the trial. The lowest yield level was observed in spelt plants of varie­ty ‘Zoria Ukrainy’ in the seed treatment with water (control variant) – from 2.74 t/ha in 2020 to 4.12 t/ha in 2022. The mass fraction of protein in grain in the variant with the use of “Chlorella suspension” among T. aestivum and T. durum varieties was distinguished by ‘Vidrada’ (15.8–15.9%) and ‘Lincor’ (14.6%), among T. spelta varieties – ‘Zoria Ukrainy’ (20.2%). Conclusions. The developed elements of the technology of winter wheat cultivation allow to increase the yield and quality of grain in the Southern Steppe of Ukraine, which confirms the relevance of this field of research.
Alzheimer Hastalığındaki Nöropsikiyatrik Semptomların Yönetiminde Güncel Gelişmeler
Authors: Sönmez Doğancan , Hocaoğlu Çiçek
Published: July 2024

Alzheimer hastalığı, bilişsel ve işlevsel bozulmalarla birlikte yaygın olarak nöropsikiyatrik semptomları içeren ilerleyici bir nörodejeneratif bozukluktur. Bu semptomlar arasında ajitasyon, depresyon ve anksiyete belirtileri, halüsinasyonlar, sanrılar, uyku bozuklukları ve davranışsal değişiklikler bulunmaktadır. Tedavide farmakoterapi, psikososyal müdahaleler ve çevresel düzenlemelerin bir kombinasyonu kullanılmaktadır. Nöropsikiyatrik semptomların tedavisinde ilaç dışı yaklaşımlar önemli bir yer tutar. İlaç tedavisi gerekli olsa da psikososyal ve çevresel düzenlemeler de kritik öneme sahiptir ve genellikle ilaç tedavisinden önce veya ilaç tedavisiyle birlikte uygulanmalıdır. Tedavide kullanılan ilaçlar arasında kolinesteraz inhibitörleri, NMDA reseptör antagonistleri, antipsikotikler, antidepresanlar ve anksiyolitikler bulunmaktadır. Bununla birlikte, farmakoterapinin yan etkileri ve etkinliği göz önünde bulundurulmalıdır. Psikososyal müdahaleler arasında eğitim, destek grupları, davranışsal terapiler ve ortam değişiklikleri yer almaktadır. Ayrıca, hasta ve bakım verenler için kaynakları kolaylaştırmak ve desteklemek önemlidir. Bu semptomların yönetiminde multidisipliner bir yaklaşım gereklidir ve bireyselleştirilmiş bir tedavi planı oluşturulmalıdır. Sonuç olarak, Alzheimer hastalığında nöropsikiyatrik semptomların etkili bir şekilde tedavi edilmesi ve yönetilmesi, hasta yaşam kalitesini ve bakım deneyimini önemli ölçüde artırabilir. Bu derleme çalışmasında Alzheimer hastalarında görülen nöropsikiyatrik semptomların patofizyolojisi, tanı ve güncel tedavi algoritmaları hakkında güncel literatür bilgileri ile tartışılacaktır.
Antiprotozoal, Anthelmintic and Antivectorial Activities of Titanium Dioxide Nanoparticles
Authors: Bologna Thainá Silva , de Sousa Isabella de Oliveira Ferrato , do Carmo Neto José Rodrigues , Nunes Thaís Amanda de Lima , Matos Beatriz Sodré , da Silva Priscilla Elias Ferreira da , Guerra Rhanoica Oliveira , Franco Pablo Igor Ribeiro , Machado Juliana Reis , Silva Anielle Christine Almeida , da Silva Marcos Vinicius
Published: July 2024

Nanotechnology has been established as a promising alternative for treating a
myriad of disease-causing microorganisms that pose threats to human health. The utilization
of nanoparticles (NPs) emerges as a strategy to enhance the therapeutic arsenal
against these diseases, especially given the tendency of many pathogens to develop resistance
to conventional medications. Notably, titanium dioxide nanoparticles (TiO2NPs)
have garnered attention for their multifaceted biomedical applications, encompassing
antibacterial, antifungal, antiviral, anticancer, antioxidant, and drug delivery properties.
This review focuses on the cutting-edge potential of TiO2NPs against helminths, protozoa,
and vectors, underscoring their pivotal role in combating these health-threatening
agents.
Exploring the Anticancer Potential of Astragalin in Triple Negative Breast Cancer Cells by Attenuating Glycolytic Pathway through AMPK/mTOR
Authors: Zeb Ahmad , Khan Walizeb , Ul Islam Waseem , Khan Faizullah , Khan Ajmal , Khan Hanif , Khalid Asaad , Najeeb Ur Rehman  , Ullah Anwar , Al-Harrasi Ahmed
Published: July 2024

Background:

Aerobic glycolysis is crucial for cancer cells to survive, grow,
and progress. In the current study, the anti-cancer effects of astragalin (ASG) on breast
cancer cells and in the glycolytic pathway through AMPK/mTOR have been evaluated.

Objective:

The objective of this study was to examine the impact of ASG, a natural
flavonoid, on glycolysis via targeting AMPK/mTOR signalling in MDA-MB-231 breast
cancer cells.

Method:

The study utilized ASG, which was isolated from Haplophyllum tuberculatum.
The cells were treated with different concentrations of ASG (20 and 40 μg/mL), and anti-
glycolytic activities were measured through cell proliferation, expression of glycolytic
enzymes (HK-2, LDH-A, GLUT-1), glucose uptake, and lactate concentration assays.
The MTT assay was used to assess cellular proliferation, while the glucose uptake and
lactate levels were determined by employing colorimetric assays. The mRNA expression
of target glycolytic enzymes was determined by qRT-PCR. The protein levels of
glycolytic targets, as well as that of AMPK and mTOR, were determined by western blot.
in silico docking of ASG was done with mTOR and AMPK proteins.

Result:

Astragalin exhibited dose- and time-dependent anti-proliferative effects in
MDA-MB-231 cells. In breast cancer cells, the mRNA and protein expression of
GLUT-1, LDH-A, and HK-2 were all significantly downregulated after receiving ASG
treatments. Furthermore, after ASG treatments, MDA-MB231 cells showed a significant
decrease in lactate and glucose uptake compared to control cells. Mechanistically, ASG
increased AMPK activation and suppressed mTOR activation in these cells. The inhibitory
role of ASG on aerobic glycolysis was prevented by treatments with compound C (an
AMPK inhibitor). However, combined treatment of compound C and ASG could nullify
the ASG-induced anti-glycolysis effect and restore the level of p-AMPK and p-mTOR in
MDA-MB231 cells. The results from molecular docking predicted that ASG had the potential
to bind AMPK and mTOR, with free energy for binding, -8.2 kcal/mol and -8.1
kcal/mol, respectively.

Conclusion:

Taken together, the findings from this study indicated that ASG might modulate
the AMPK/mTOR pathway to inhibit aerobic glycolysis and proliferation of MDAMB231
breast cancer
A Simple Aptasensor Based on Fluorescence Resonance Energy Transfer
for the Rapid Detection of Cadmium (II) In Water And Food
Authors: Zhu Jiangxiong , Wang Yang , Wang Lumei , Geng Xueqing , Yang Linnan , Zhao Ting , Deng Yun
Published: July 2024

Objective:

The objective of this study is to develop a novel fluorometric aptasensor employing
fluorescence resonance energy transfer (FRET) for the detection of Cadmium (II) (Cd2+) in
water and food samples. The constructed aptasensor employed a fluorophore-quencher labeled aptamer
combination not previously reported for Cd2+ detection. Additionally, its simple mix-anddetect
pattern without immobilization or material-assisted steps represented an innovative design.

Methods:

Utilizing 6-carboxyfluorescein (FAM)-modified aptamers and maleimide (BHQ-1)-
modified aptamer complementary chain to construct a fluorescent detection probe, this aptasensor
achieved a rapid, sensitive, and selective detection of Cd2+. Without Cd2+, the aptamer and its complementary
strand undergo base pairing, bringing the FAM closer to the BHQ-1, leading to FRET
and a subsequent decrease in fluorescence intensity. The introduction of Cd2+ preferentially brought
to the aptamer, changing its conformation and preventing the quenching of FAM by BHQ-1, thereby
restoring the fluorescence intensity of the aptasensor.

Results:

Following optimization of experimental parameters, the aptasensor exhibited a linear response
to Cd2+ concentrations ranging from 5 to 1200 nM, with a detection limit (LOD) of 0.43 nM.
The aptasensor’s performance was unaffected by the presence of various ions, indicating its high
specificity. Moreover, it could rapidly and accurately detect Cd2+ in water and food samples, including
tap water, lake water, grapes, cabbage, and broccoli, demonstrating its substantial potential for
practical application.

Conclusion:

Therefore, the developed aptasensor represents an important tool for effective Cd2+
detection in water and food matrices, highlighting its potential as a critical tool for environmental
monitoring and food safety.
Comparison between Ribosomal Assembly and Machine Learning Tools
for Microbial Identification of Organisms with Different Characteristics
Authors: Chau Stephanie , Rojas Carlos , Jetcheva Jorjeta G. , Markart Mary , Vijayakumar Sudha , Yuan Sophia , Stowbunenko Vincent , Shelton Amanda N. , Andreopoulos William B.
Published: July 2024

Background:

Genome assembly tools are used to reconstruct genomic sequences from
raw sequencing data, which are then used for identifying the organisms present in a metagenomic
sample.

Methodology:

More recently, machine learning approaches have been applied to a variety of bioinformatics problems, and in this paper, we explore their use for organism identification. We start by
evaluating several commonly used metagenomic assembly tools, including PhyloFlash, MEGAHIT,
MetaSPAdes, Kraken2, Mothur, UniCycler, and PathRacer, and compare them against state-of-theart deep learning-based machine learning classification approaches represented by DNABERT and
DeLUCS, in the context of two synthetic mock community datasets.

Result:

Our analysis focuses on determining whether ensembling metagenome assembly tools with
machine learning tools have the potential to improve identification performance relative to using the
tools individually.

Conclusion:

We find that this is indeed the case, and analyze the level of effectiveness of potential
tool ensembling for organisms with different characteristics (based on factors such as repetitiveness,
genome size, and GC content).
A brief review of digitization as a modern and technical face of Manuscript Preservation
Authors: Vaishali Chandrashekhar Nistane  , Brijesh Ramprakash Mishra
Published: July 2024

Manuscripts are the treasure of knowledge reflecting the intellectual expertise of ancient scholars. Preserving these repositories of information and ensuring their easy access is crucial and is need of an hour. In today’s modern and digital world, the most preferred method of preservation of manuscript is digitization. This article is a brief review of digitization as a new age preservation method for manuscripts.
Review on importance of Textual Criticism in Ayurveda Manuscriptology
Authors: Saniya S. Gosavi  , Brijesh R. Mishra
Published: July 2024

Ayurved, the ancient Indian system of medicine, developed as a result of the accumulated wisdom and practical experiences of many generations. The knowledge gained by ancient seers of Ayurved was meticulously recorded and passed down primarily through Oral medium and then through manuscripts. Manuscripts hold the new, previously unknown and rare knowledge. Concurrently, further advancement to the existing knowledge is possible through some rare and hitherto unknown manuscripts. Indian Digital sources such as Namami, Niimh-Amar have collected approximately 4249 Ayurved manuscripts from which only few are published.[1] Manuscripts preserved in libraries have limited accessibility. To reach a wider audience, they should be published. The most important scholarly aspect of manuscriptology is Textual Criticism and edition of the manuscripts for publication. The vast knowledge available in manuscripts should be evaluated by using the stepwise methods of Textual Criticism. The present study gives the brief information about Textual criticism and provide the importance of the same in Ayurved manuscripts. Textual criticism deals with studying the first formal documents of the writing, authenticating them, and identifying their variants. The objective is to recover the text from a manuscript to its earliest form and preserve its original meaning. Critical editions of Ayurvedic texts, based on multiple manuscripts, secure the heritage of this valuable knowledge, which can be published and used by Ayurved students and physicians in today’s era.
Role of Ayurvedic herbs in managing Shukra Dosha - A Review
Authors: Randeep Chaudhary  , Minakshi Kaundal
Published: July 2024

Ayurveda possesses a wealth of ancient and well-established theories aimed at achieving holistic physical, mental and social well-being. To comprehend Ayurvedic state of well-being, an individual must delve into the study of Dosha, Dhatu, and Mala. Ayurvedic texts outline seven Dhatus with Shukra being the seventh Dhatu, revered as the essence of all Dhatus. Recent studies have frequently indicated that despite men exhibiting favourable semen parameters, they may still face difficulties in conceiving after a prolonged period of unprotected intercourse. Ayurveda places significant emphasis on the preservation of both physical well-being and emotional contentment. In order to attain overall happiness and a harmonious existence, it becomes imperative to accomplish all life's objectives. The creation of offspring is an integral aspect of human life, alongside the pursuit of happiness. This abstract explores the role of Ayurvedic herbs in managing Shukra Dosha. Commonly used herbs include Musli, Kapikacchu, Jatiphla, Kupilu etc. each offering unique benefits. Overall, Ayurvedic herbs present promising avenues for managing Shukra Dosha and improving overall reproductive health.
Role of Ayurvedic herbs in managing Urinary System Diseases: A Review
Authors: Singla Loveneesh , Minakshi Kaundal
Published: July 2024

The urinary system plays a crucial role in eliminating waste and maintaining fluid balance in the body. However, various factors such as lifestyle, dietary habits and genetic predisposition can lead to urinary system diseases, ranging from urinary tract infections (UTIs) to more severe conditions like kidney stones and chronic kidney disease. Ayurveda, an ancient Indian system of medicine, emphasizes the balance of bodily systems through diet, lifestyle modifications and herbal remedies. According to Ayurveda, urinary system diseases are often manifestations of imbalances in the body's Doshas Vata, Pitta and Kapha. Herbal remedies are tailored to restore this balance and promote overall well-being rather than merely treating symptoms. This abstract explores the role of Ayurvedic herbs in managing urinary system diseases. Ayurveda, an ancient system of medicine offers a plethora of herbs known for their therapeutic properties in promoting kidney health, supporting urinary tract function and alleviating symptoms of various urinary disorders. Commonly used herbs include Gokshura, Punarnava, Varuna, Pashanbhed, Bijaka, Bimbi, Karavellaka, Vata, Jambu etc. each offering unique benefits such as diuretic, anti- urolithic, nephroprotective, anti-inflammatory and antimicrobial effects. Overall, Ayurvedic herbs present promising avenues for managing urinary system diseases and improving overall urinary health.
A comparative clinical study to assess the effect of Amlapitta Vinashaka Yoga and Pantoprazole with Sheetali Pranayama in the management of Amlapitta
Authors: Channamma  , Prabhu. C. Nagalapur  , Chandrashekaraddi S. Karamudi
Published: July 2024

Background: In this modern era there has been an unprecedented increase of incidences related to GI system due to marked change in life style. Diet pattern, behavioral pattern & mental stress & strain, these multiple factors lead to a clinical condition known as the Amlapitta. Symptoms of Amlapitta as explained in Ayurveda are nearer clinical entity with symptoms of hyperacidity Gastro-intestinal disorder mentioned in modern science. Aim and Objectives: This study aims to evaluate the efficacy of Amlapitta Vinashaka Yoga and Pantoprazole with Sheetali Pranayama. Materials and Methods: An open Randomized Comparative clinical study was conducted in 45 Patients. Patients were randomly selected in to 3 groups. Group A - 15 patients were treated with Amlapittavinashaka Yoga and Sheetali Pranayama, Group B - 15 patients were treated with Pantoprazole and Sheetali Pranayama and Group C - 15 patients were treated with Sheetali Pranayama & placebo. Results: The overall study suggestive of in group A, 7% patients showed moderate relief, 53% patients showed marked response to treatment where as 40% patients showed complete Response to the treatment. In group B 7% patients showed moderate response to treatment, 80% patients showed marked response to the treatment, where as 13% patients showed complete relief to the treatment. In group C 20% patients showed mild relief, 47% patients showed moderate response to treatment where as 33% patients showed marked response to the treatment. Conclusion: The study revealed that the study drug Amlapitta Vinashaka Yoga and regular practice of Sheetali Pranayama schedule 10 cycles at afternoon before meal is effective in treating Amlapitta (Hyperacidity).
A game-changer in enhancing Endometrium Health - Uttara Basti as a promising alternative to PRP therapy & G-CSF instillation with superior impact on Thin Endometrium Cases
Authors: Bhavana G  , Papiya Jana
Published: July 2024

A healthy conception results due to the influence of Ritu, Kshetra Abu, Bija Samyoga, Garbha Sambhava Samagri as mentioned in Ayurvedic classics, any defect in the above component can lead to Vandyatwa. Kshetra is one of the most important factors that may have its impact on conception and growing fetus as well as it is considered as the site of implantation in the Garbhashaya which bears the fruit of conception and can be considered endometrium. Endometrium if unhealthy or thin can impact on maintaining the balance of Artavavaha Sroto function. Hence, we need to explore the function of endometrium and the pathogenesis related to it. In Ayurveda among the various Stanika procedures, Uttara Basti specifically stands out as a highlighted and well-practiced therapy for addressing infertility by promoting endometrial growth and enhance embryo implantation.  The specific formulation mentioned in Ayurvedic classics contains drugs which are having Garbhasthapana actions and they also have Brumhaniya properties which have its action on correcting endometrium.
Ayurvedic approach to Ovarian Cyst - A Case Report
Authors: Rasmi Hadimani  , Gururaj S. Metri
Published: July 2024

An ovarian cyst is a fluid-filled sac that develops in ovary. They're very common in gynaecological practice. In the present case study 36 years old women consulted to Prasooti Tantra evum Stree Roga outpatient department with complain of pain in lower abdomen, dysmenorrhoea, nausea during menstruation constipation and generalized weakness. She was advised for USG and findings were Right ovary simple follicular cyst measuring 38 x 35mm. This case was treated for 3 months with different Ayurvedic formulations and therapies with aim to alleviating the symptoms. Treatment protocol was Koshtashuddhi, Yogabasti and oral medications Varunadi Kwatha and Kanchanar Guggulu. Follow up USG showed complete disappearance of cyst and symptoms also subsided completely. So, this study indicates ovarian cyst can be cured successfully with Ayurvedic approach.
An Ayurvedic approach in the management of Avabahuka (frozen shoulder) - A Case Study
Authors: Shubhangini S. Kolar  , Karthik K.V  , Shakti S. Hiremath
Published: July 2024

Shoulder joint (Amsa Sandhi) has its clinical importance because of wide range of motion. Frozen shoulder is a musculoskeletal disorder characterized by stiffness and pain in the shoulder joint. This typically occurs in cycle of 3 stages, painful phase, stiff phase, and thawing phase. This entity is resembling with Avabahuka, in Ayurveda. Avabahuka is a disorder of Amsa sandhi, and it has been mentioned by Acharya Sushruta under 80 types of Vatavyadhis. It is commonest condition in orthopaedic hospital. Frozen shoulder causes pain and restricted movements, which hampers daily activity of the patient. Modern medicine has NSAIDs, steroids for such condition but it is costly, have much side effects and gives temporary relief. hence a case study was carried out using Ayurvedic approach, which got effect on the range of movements. A 62 years female arrived at OPD, SSVRAMC with main complaints of left shoulder pain, stiffness, restricted movements, associated with disturbed sleep due to the pain since 1 month.
A case study on the management of alcohol dependence through Ayurveda
Authors: Sangamesh M  , Raviprasad Hegde  , Vinitha Dsouza
Published: July 2024

Alcohol Use Disorder (AUD) is a medical condition characterized by problematic and unhealthy patterns of alcohol consumption. It encompasses a wide array of signs and behaviours associated with alcohol abuse and is recognized as one of the most prevalent psychiatric disorders, affecting a significant portion of the population. The repercussions of alcohol misuse extend beyond individual health, influencing various aspects of society such as social dynamics, economic factors, and public health. In Ayurveda, which embraces a holistic and comprehensive approach to life, alcoholism is referred to as Madatyaya. It is regarded as a lifestyle disorder and a detrimental dependency condition. The treatment of alcohol use disorder in Ayurveda is tailored to the patient's strength (Rogi Bala) and the severity of the condition (Roga Bala), utilizing approaches such as Shamana, Shodhana, and Satvavaja Chikitsa. This case study aims to illustrate the holistic treatment of alcohol use disorder using Ayurveda, emphasizing the comprehensive approach to addressing this condition.
Evaluation of the effect of Marma Chikitsa in the management of Frozen Shoulder (Avabahuka) - A Pilot Study
Authors: Aayushi Chouhan  , Rita Marwaha  , Nisha Bhalerao
Published: July 2024

Frozen shoulder (adhesive capsulitis - capsule thickens and tightens around the shoulder joint, restricting its movement) is a condition characterized by stiffness and pain in the shoulder joint, consists. Movement of the shoulder joint is restricted, with loss of active and passive range of motion, and leads to lack of use due to pain. Stiffness is also present there. Avabahuka is one such disease that hampers the day-to-day activity of an individual. Acharya Sushruta has classified Avabahuka, a disease of the Amsa Sandhi (shoulder joint), under the eighty varieties of Vata Vyadhi. Amsa Shosha (wasting of the shoulder) can be considered the preliminary stage of the disease, where loss or dryness of Sleshaka Kapha from Amsa Sandhi occurs. Its growing prevalence in today's world necessitates efficient management with quick and long-lasting effects. Therefore, in such cases, Marma Chikitsa, an alternate Ayurvedic therapy, can be recommended. Multiple sittings are required for better results. Avabahuka can be treated with improvements, regardless of its severity or duration. In present pilot study, emphasis is laid upon eight specific Marma Sthan (or energy points) for the management of Avabahuka by considering the related literature, and an attempt is made to treat the patient of Frozen Shoulder (Avabahuka) by Marma Chikitsa.
An approach of Ayurveda Clinical Diagnosis in managing Myasthenia Gravis - A Case Report
Authors: Nalina D S  , Surekha Pai
Published: July 2024

Background: Myasthenia gravis (MG) is an autoimmune neuromuscular disorder leading to muscle weakness due to disrupted nerve-muscle communication. Although not explicitly described in Ayurveda texts, managing of MG requires an understanding of Nidana Panchaka and varied examination method as per Ayurveda. Brief Case Report: A 27 year old male patient presented with progressive symptoms of MG for 11 years initially Chakshurendriya Lakshana and later affecting the Mamsa Dhatu. Diagnosis was made after 8 years of onset of symptoms. Lifestyle factors and routines were identified as contributing Nidanas (causes). Conclusion: Employing Ayurvedic principles a holistic treatment approach effectively managed the patient’s symptoms, emphasizing the importance of understanding Nidana Panchaka and Pareeksha for formulating comprehensive treatment strategies. The patient’s feedback showed significant improvement and enhanced quality of life following Ayurveda treatment. This case report demonstrates the applicability of Ayurveda principles in managing complex autoimmune disorders like MG, emphasizing individualized treatment strategies focusing on the root cause and holistic well-being of the patient.
Effect of Marma Chikitsa in pain management of Sandhivata (Osteoarthritis) - A Single Case Study
Authors: Mahima Asthana  , Rita Marwaha  , Pankaj Gupta  , Nisha Bhalerao  , S. D. Panda
Published: July 2024

Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. The most common symptoms are joint pain and stiffness. Usually, the symptoms progress slowly over years. In this paper there is a case of 52 year old female patient that came to our institute with complain of pain, swelling and stiffness of right knee joint since 1 year. X - ray suggested narrowing of the space between the bones in the joint. X - ray also shows spurs around the joint. In this case study of Marma Chikitsa is done in the pain management of Osteoarthritis.
A Case Study on Raktaja Granthi (Pyogenic Granuloma)
Authors: Anuja Kitturkar  , Siddanagouda A. Patil
Published: July 2024

Agnikarma is regarded as the best of the Anushastras because of its quick action and long-lasting cure. It is said to have the ability to cure ailments that cannot be cured by other therapeutic methods such as Surgery, Kshara, and pharmacological management. A wide number of references are available in Ayurveda literature about Granthi which lays emphasis on benign lesions. Various types of Granthi have been enlisted, and among these Raktaja Granthi is a form of swelling in which the pathology is of vascular origin. Ayurveda has bestowed wide range of surgical and para surgical knowledge to the world which has been utilized in treating many of the diseases. Following is a case of Raktaja Granthi in which Agnikarma was done and the lesion was excised with ease, follow up was taken for about six months in order to see any recurrence. Observation: It was observed that within a month the site of lesion was healed without any sign of slough or discharge.
An observational study to evaluate Rutumati Lakshnas during ovulation period in different Prakruti
Authors: Savita Vangi
Published: July 2024

Ovulation period is one of the most important phase which is a course of passing of menstrual period. Rutumati Lakshana’s are conditions of manifestation of physiological & psychological status experienced by women during ovulation period. Current studies identified age group of 18 - 35 yrs. (who is having regular menstrual cycle (at least for past 2 months). Objectives: To evaluate the variation of Rutumati Lakshana’s in different Prakruti during ovulation period. In present study questionnaire was given to assess the Deha Prakruti than it was categorized into 50 Vata, 50 Pitta and 50 Kapha Pradhana Prakruti, thereafter assessment of health status using HSQ - 2.0 and ovulation period using calendar method variation in Rutumati Lakshana’s are observed during period using self prepared questionnaire.
A conceptual analysis on Atma Vijnanam from health care perspective: A Review of Ayurvedic Classics
Authors: Kshirabdhi Tanaya Rautaray  , Shiva Prasad Mohanty  , Raka Jain
Published: July 2024

For millennia across the globe knowledge about the outer world i.e. physical knowledge and self-knowledge have been well recognized as the core principle of life and living. Exploration of self-knowledge through understanding the fundamental cognitive part of the self i.e., self-concept and self-realization provide the firm basis for attainment of broader aspect of health as well as for fulfillment of basic pursuits of human life (Purusartha). But the importance of self-concept, self-actualization, self-realization etc. both for a recipient and health care provider from health care perspective are relatively underdeveloped. The most neglected area in medical field is ignorance about exploration of self-knowledge and self-awareness both by healthcare provider and recipient. But the philosophy of Ayurved and visionary thought of great seers of Ayurveda discovered the knowledge of true self lies at the root of all knowledge such as virtue, health, happiness etc to get rid from all miseries created by self. An effort has been made by the author for exploration of value of understanding the true self and self-knowledge from health care perspective as vividly explained in Ayurvedic classics.
THE RELATIONSHIP BETWEEN HYPERTENSION KNOWLEDGE WITH EATING HABITS AND BODY MASS INDEX (BMI) IN MALANG
Authors: Panjaitan Damaris Gabrielle Valentine ,   Bachelor Study Program of Medicine, Faculty of Medicine Universitas Brawijaya Malang, Indonesia, Zuhriyah Lilik , Setijowati Nanik Setijowati
Published: July 2024

Hypertension or high blood pressure is a commonly found cardiovascular disease and also the highest cause of death in society. Hypertensive patients with good knowledge regarding their disease are known to have great treatment adherence and salt reduction habits. Hence, having better knowledge is expected to form healthier habits and reduce the risk of developing hypertension. This study aims to determine the relationship between hypertension knowledge, eating habits, and body mass index (BMI) in Malang. The research was conducted by distributing an online questionnaire in form of Google Forms in October 2021 and January 2022 to people who reside in Malang. This research used an observational analytic approach and cross-sectional design. Data needed in this study was taken using a demographic questionnaire, Hypertension Knowledge-level Scale that was translated to Indonesian, and modified questions from Consumptions of High-Risk Diet from the Basic Health Research 2016 conducted by the Ministry of Health of Indonesia. As 212 respondents submitted the questionnaire. Based on the result, most respondents have a high knowledge level (75,9%), normal eating habits (85,8%), and abnormal body mass index (67,5%). Chi-Square test results indicated a significant relationship between knowledge and eating habits (p=0,017), no significant relationship between knowledge and body mass index (0,369), and no significant relationship between eating habits and body mass index (p=0,524).
Filmes e recursos audiovisuais como material didático
Authors: Queiroz Dias Rocha Felipe
Published: July 2024

O filme é compreendido como um advento multifacetado capaz de criar mundos, animar vidas e levantar questões. Trata-se de um material didático de primeira grandeza que pode chegar às salas de aula e ser usado sob diversas perspetivas. Objetivou-se desvelar porquê filmes são utilizados pelos docentes. Participaram da pesquisa 15 docentes que utilizam filmes como material didático, sendo nove mulheres (60%) e seis homens (40%). Todos os voluntários exercem a função em Portugal e ensinam no nível superior, sendo que 60% trabalham no Porto, 20% em Braga e outros 20% em Lisboa. Os participantes foram buscados a esmo. Resultou-se que os sujeitos utilizam filmes por quatro razões: atrair/motivar mais os estudantes, complementar ou ilustrar o conteúdo ensinado em aula por meio da peculiaridade audiovisual, diversificar os métodos de ensino e promover reflexão crítica. A teoria interacionista de Lev Vygotsky foi utilizada como referencial teórico para analisar os resultados. Os filmes são um recurso bem aceite por docentes e discentes, os quais conseguem explicar e entender melhor, respetivamente, determinados conceitos. Na ótica vygotskiana, o efeito benéfico do filme se dá pela ZDP ser acedida pelos signos fílmicos, de modo a promover a transição do desenvolvimento real para o potencial.
Análisis documental de los rasgos de salud mental en personal militar latinoamericano
Authors: Andrade-Medina Miguel Ángel , Fula-Martin Kristhian Alejandro , Mazo-García Marx Emanuel , García-Carrillo Jimmy Anderson , Urazan-Chinchilla Juan Camilo
Published: July 2024

El objetivo del estudio fue analizar los rasgos de salud mental en el personal militar latinoamericano para identificar posibles riesgos y necesidades de atención. Se realizó una revisión sistemática de la literatura científica publicada entre 2000 y 2023, incluyendo estudios que evaluaron la prevalencia de síntomas de salud mental en personal militar de países latinoamericanos. Los resultados del estudio mostraron una alta prevalencia de síntomas de salud mental en este grupo, siendo los más comunes la ansiedad, la depresión, el estrés postraumático y el abuso de sustancias. Se identificaron varios factores de riesgo para la salud mental, como el combate, la exposición a traumas, el trabajo prolongado en condiciones difíciles y la falta de apoyo social.
Etika berpolitik pemimpin masa lampau berbasis naskah Sunda
Authors: Sumarlina Elis Suryani Nani , Permana Rangga Saptya Mohamad , Darsa Undang Ahmad
Published: July 2024

Benar  adanya apabila dikatakan bahwa banyak kesulitan yang dihadapi dalam menggarap naskah-naskah  Sunda Kuno. Akan tetapi, harus disadari pula bahwa di dalam sebuah naskah Sunda kuno terdapat nilai-nilai kearifan lokal yang bermanfaat bagi kehidupan masyarakat masa kini.  Isi naskah Sunda Kuno mengungkap beragam ilmu yang bisa dijadikan sebagai referensi literasi bagi ilmu lain saat ini, yang berkaitan dengan  historiografi tradisional, toponimi, pandangan hidup, sistem pemerintahan atau pembagian kekuasaan, konsep kepemimpinan, etika berpolitik,  dan  unsur-unsur kebudayaan  lainnya, sebagai bahan dalam upaya menggali, identitas masyarakat pendukung kebudayaan tersebut. Dengan demikian, upaya penggalian dan penggarapan naskah-naskah kuno perlu dilakukan secara sungguh-sungguh, intensif,  dan berkesinambungan. Teks naskah Sunda kuno yang sangat menarik untuk dibahas dalam tulisan ini berkaitan dengan etika berpolitik para pemimpin atau raja-raja Sunda masa lampau, yang eksistensinya terungkap dalam naskah Sanghyang Siksakandang Karesian, Fragmen Carita Parahiyangan, Amanat Galunggung, dan Sanghyang Hayu, yang ditulis pada abad ke-16 Masehi. Etika berpolitik raja-raja zaman dulu berkaitan erat dengan konsep kepeminpinan, sistem pemerintahan dan pembagian kekuasaan, serta karakter dari peminpin itu sendiri. Dikaji melalui metode penelitian deskriptif analisis, dan metode kajian filologi, komunikasi politik, historiografi tradisional, dan kajian budaya secara multidisiplin. Diharapkan mampu menungkap bagaimana etika berpolitik raja atau pemimpin Sunda masa silam, melalui naskah-naskah Sunda Kuno abad-16, yang akhirnya dapat membuka cakrawala dan wawasan ilmu pengetahuan bagi ilmu-ilmu lain secara multidisiplin.