bluuebunny/crossref_metadata_2025 huggingface dataset:
Möglichkeiten der tiefenpsychologisch fundierten Hypnosepsychotherapie in der Behandlung Drogenabhängiger
Authors: Köpke Eva
Published: October 2024

Die vorliegende Arbeit beschreibt die Schnittmenge von tiefenpsychologischen Ansätzen, suchttherapeutischen Konzepten und Hypnosetherapie in der Behandlung Drogenabhängiger. Praktische Beispiele zeigen die Wirkfaktoren auf.
Das Geheimnis im offenen Raum
Authors: Uhlmann Tina
Published: October 2024

/
Jedem Anfang wohnt ein Zauber inne
Authors: Hinnen Peter
Published: October 2024

/
Aus dem Open Space zurück in die Praxis
Authors: Uhlmann Tina , Wahlen Marlene
Published: October 2024

/
Perspektiven
Authors: Cottier Suzanne Claire
Published: October 2024

/
A Gray Scale Image Compression Using Hierarchical DWT Decomposition and Mixing Quantization Techniques
Authors: Mahdi Noor Sabah , Al-Khafaji Ghadah
Published: October 2024

This paper describes a hybrid grayscale compression system based on the discrete wavelet transform (DWT) and a polynomial coding technique for mixing quantization schemes to increase the compression ratio while maintaining quality. The proposed compression system consists of three main steps: first, decomposing an image using a three-level DWT; second, applying the 2-D linear polynomial coding technique to the approximation sub-band; and third, dividing the detailed sub-bands of each level into the Most Significant Value (MSV) and Least Significant Value (LSV), where the former is compressed using iterative scalar uniform quantization and the latter by soft quantization thresholding. For testing the performance of the suggested compression system, five standard images of size 256×256 pixels were adopted. The suggested technique showed superior performance in terms of reconstructed (decoded) image quality and compression ratio (gain), where the compression ratio is between 21–27 with a PSNR value between 36–38 dB and the compression ratio of JPEG is between 7–20 with a PSNR value between 33–37 dB.
Usos del dativo ético en español: percepciones de los hablantes e implicaciones para su abordaje en la clase de ELE/L2
Authors: Baquero Caldas Andrea Marcela , Nieto Martín Gloria Viviana
Published: October 2024

Desde el punto de vista sintáctico, el uso del dativo ético es superfluo en español; sin embargo, su valor expresivo (familiar, afectivo, cercano) motiva a los hispanohablantes nativos a emplearlo con frecuencia, en especial, en interacciones orales informales. Este artículo presenta los resultados de una investigación sobre las percepciones de hablantes nativos y no nativos acerca del cambio de significado en algunas construcciones con y sin dativo ético, sus creencias sobre el uso de este elemento pragmático, analizadas según cuatro variables (género, edad, variedad geográfica y contextos comunicativos formales o informales). Concluimos que mientras el género no parece ser una variable determinante para su uso, la edad y la variedad geográfica sí lo son. Con base en estos resultados, proponemos la presentación explícita del dativo ético en clases de ELE/L2 en Hispanoamérica, desde nivel A2, y diseñamos un material para apoyar su tratamiento didáctico, desde los enfoques de la gramática pedagógica y la gramática visual.
The Impact of Using Say Something Strategy on Iraqi EFL University Students' Achievement in Reading Comprehension
Authors: Jasim Saad Rokan
Published: October 2024

Reading is the most important skill among the four skills in learning English and being able to comprehend various English texts as expected. Yet, the experience has not seemed to be realized. The goal of the "Say Something Strategy" is to assist students in understanding what they are reading by predicting, questioning, clarifying, connecting, or commenting. Telling students to "say something" about the reading, or offering them specific things to say, keeps them engaged with the content.
    In this study, the Say Something strategy is an appropriate strategy to progress accomplishment for improving students' reading comprehension success. The study's sample comprises of second-year university students from the English Department, the College of Art, and Tikrit University during the academic year 2022–2023. It has been randomly chosen and has been divided into two groups, the experimental group with (33) students taught by Say Something Strategy and the control group with (33) students without Say Something Strategy, both groups completed the same reading comprehension test. An accomplishment exam was developed, validated, and administered to the two groups involved. The essential data has been collected and statistically analyzed. Because of the implementation of the Say Something Strategy, the obtained results show that there are statistically significant differences in the success of the two groups of students in favor of the experimental group.
Constructive and destructive effects of mediatization of family memory
Authors: Tselykovskiy Aleksey Andreevich
Published: October 2024

The paper analyzes the peculiarities of family memory transformation under the influence of digitalization. In the modern world, new media begin to exert a determining influence on the formation of the image of reality, leading to the emergence of a special media culture that transforms familiar social phenomena. To reveal the specifics of the phenomenon of family memory we use the concept of midi-memory, which describes the mechanisms of emergence, storage and translation of collective representations of the past in the conditions of mediatization and digitalization. In such conditions, the boundary between cultural and communicative memory is gradually erased, and the number of subjects involved in the construction of representations of the past increases significantly. As a result, the mechanism of constructing images of the past is changing. These processes lead to the need to analyze the destructive and constructive effects of the mediatization of collective and, in particular, family memory.The main methodological principle of the study is the analysis of various forms of collective memory that appear in modern reality under the influence of digitalization. In modern realities, which are gradually blurring the line between cultural and communicative memory, collective representations of the past are being transferred into the format of media memory. Mediatization of family memory can contribute to the formation of national identity through the inclusion of significant national events in the images of the past present in family memory. A significant role in these processes is played by significant symbols of the Soviet period, broadcast by modern media practice. This increases the risk of purposeful distortion of images of the past. In the end, the media blur the boundaries of family memory, replacing images of the past with images constructed by media space.
Universal Birkhoff Theory for Fast Trajectory Optimization
Authors: Ross Isaac M.
Published: October 2024

Over the last two decades, pseudospectral methods based on Lagrange interpolants have flourished in solving trajectory optimization problems and their flight implementations. In a seemingly unjustified departure from these successes, a new starting point for trajectory optimization is proposed. This starting point is based on the recently developed concept of universal Birkhoff interpolants. The new first-principles’ approach offers a substantial computational upgrade to the Lagrange theory in completely flattening the rapid growth of the condition numbers from [Formula: see text] to [Formula: see text], where [Formula: see text] is the number of grid points. Furthermore, a Birkhoff discretization offers the theoretical possibility of an infinite-order rate of convergence. In addition, the Birkhoff-specific primal-dual computations are isolated to a well-conditioned linear/convex system even for nonlinear, nonconvex problems. This is Part I of a two-part paper. In Part I, the new theory is developed on the basis of two hypotheses. Other than these hypotheses, the theory makes no assumptions on the choices of basis functions, be they polynomials or otherwise, or even the distribution of grid points. Several theorems are proved to establish the mathematical equivalence between direct and indirect Birkhoff methods. In Part II of this paper, it is shown that a select family of Gegenbauer grids satisfy the two hypotheses required for the theory to hold. The theory developed in Part I is used in Part II to produce the fast computational implementation.
Droplet Shape Representation Using Fourier Series and Autoencoders
Authors: Durve Mihir , Tucny Jean-Michel , Bhamre Deepesh , Tiribocchi Adriano , Lauricella Marco , Montessori Andrea , Succi Sauro
Published: October 2024

The shape of liquid droplets in air plays an important role in the aerodynamic behavior and combustion dynamics of miniaturized propulsion systems such as microsatellites and small drones. Their precise manipulation can yield optimal efficiency in such systems. It is desired to have a minimal representation of droplet shapes using as few parameters as possible to automate shape manipulation using self-learning algorithms, such as reinforcement learning. In this paper, we use a neural compression algorithm to represent, with only two parameters, elliptical and bullet-shaped droplets initially represented with 200 points (400 real numbers) at the droplet boundary. The mapping of many to two points is achieved in two stages. Initially, a Fourier series is formulated to approximate the contour of the droplet. Subsequently, the coefficients of this Fourier series are condensed to lower dimensions utilizing a neural network with a bottleneck architecture. Finally, 5000 synthetically generated droplet shapes were used to train the neural network. With a two-real-number representation, the recovered droplet shapes had excellent overlap with the original ones, with a mean square error of [Formula: see text]. Hence, this method compresses the droplet contour to merely two numerical parameters via a fully reversible process, a crucial feature for rendering learning algorithms computationally tractable.
Tangential Mode Combustion Oscillation of a Bluff-Body-Stabilized Diffusion Flame: Experiments
Authors: Liu Yunpeng , Xu Longchao , Cheng Ronghui , Guo Peng , Yan Yingwen
Published: October 2024

Addressing the issue of tangential mode combustion oscillation prevalent in aviation engine afterburners, this study targets bluff body diffusion flames. Innovatively, acoustic cavities were installed on either side of the bluff body flame, forming a tangential mode oscillation. The study employed experimental methods to study the flame pulsation characteristics under tangential oscillation, identifying the phase distribution of the flame front as a distinct feature differentiating it from conventional longitudinal mode oscillation. Furthermore, it was noted that the multiperiodic pulsation of the flame surface significantly contributes to the complex variability of the flame transfer function/flame description function. The research then established a phase relationship among velocity pulsation, pressure pulsation, and heat release rate pulsation, uncovering the phase coupling mechanism inherent in oscillatory combustion. It also delved into the impact of equivalence ratio and bluff body structure on tangential mode oscillation. Modifications to the bluff body structure led to a significant suppression of oscillation, reducing the amplitude by up to 81.3%. Thus, the study concluded that the flame dynamic response characteristics play a crucial role in determining the thermoacoustic coupling intensity, especially when the combustion system’s acoustic properties are stable. This finding lays a theoretical foundation for future endeavors to mitigate tangential mode oscillatory combustion in afterburners.
Bayesian Updating Method Under Random and Interval Hybrid Uncertainties
Authors: Feng Kaixuan
Published: October 2024

Bayesian updating is an effective method for refining the random distribution model of the system when new observational information is gathered. To deal with the problem with multisource uncertainty, a Bayesian updating method under random and interval hybrid uncertainties is originally established in this paper. In the proposed method, the likelihood function is firstly built by considering the error of the observation and the hybrid uncertainties of the model prediction. Then, the posterior information of the random model inputs can be refined based on the defined likelihood function and the prior information. Finally, to efficiently obtain the posterior information of the random model inputs, an adaptive kriging method is developed. In this method, different learning functions are employed to accurately predict the extrema and classify the candidate samples, respectively. The significant novelty of the proposed adaptive kriging method is to design a posterior statistical information-oriented stop criterion. Four computational examples are used to illustrate the feasibility and rationality of the proposed Bayesian updating method.
HabSim-HMS: A Systems Testbed to Investigate Situational Awareness for Extraterrestrial Habitation
Authors: Murali Krishnan R , Zhang Zixu , Hao Kairui , Manikkan Sreehari , Parsons Paul , Dyke Shirley J. , Bilionis Ilias , Wang Jiachen , Xue Chuanyu , Han Song , Azimi Mohsen
Published: October 2024

Deep-space habitation presents unique challenges in operating complex control-based systems in distant and disruptive environments far from Earth. The capability to handle unforeseen situations and manage system health is crucial for resilient operations in deep space. Trusted health management strategies operational on the International Space Station (ISS) heavily rely on ground control support. These strategies must adapt to cope with sizable communication delays imposed by the infrastructure limitations or light distances that separate ground control and the habitat. Alternative approaches that increase reliance on artificial intelligence-based onboard autonomy are constrained by limited onboard computing and risks associated with human-system integration. There is an increased need to study the design and architecture of the health management system (HMS) of such complex systems to address autonomy challenges for deep-space habitation. This paper presents a model-based HMS testbed developed at the Resilient Extra-Terrestrial Habitats Institute that is part of the HabSim, a system-of-systems simulator of a smart habitat. The testbed is designed to facilitate performance assessment of critical health management functions essential to enable fault-management autonomy, situational awareness, and interface-based mission control. In this paper, the HMS testbed is motivated and placed within HabSim, the architecture of its components is detailed, and the testbed features are demonstrated through an illustrative example. The lessons learned in developing this testbed that may be useful for others seeking to solve similar problems are also discussed.
Tratamento cirúrgico versus clínico para pacientes com diabetes mellitus tipo 2 e obesidade leve a grave
Authors: Gama Leonardo Luiz , Bonilha Rebeca de Castro Pena Gama
Published: October 2024

Objetivo: Comparar o tratamento cirúrgico versus clínico para pacientes com diabetes mellitus tipo 2 (DM2) e obesidade leve a grave. Avaliando os benefícios das duas modalidades terapêuticas e buscando responder qual traz mudanças mais significativas nos parâmetros da DM2. Métodos: Trata-se de uma revisão integrativa da literatura nas bases de dados National Library of Medicine e Biblioteca Virtual em Saúde. Foram utilizados os Descritores em Ciências da Saúde (DeCS): “cirurgia bariátrica”, “diabetes mellitus”, “resultado de tratamento”. Os critérios de inclusão foram texto completo gratuito, ensaio clínico, teste controlado e aleatório, publicados em inglês, português e espanhol no intervalo de 2014 a 2024. Resultados: Foram incluídos 12 ensaios clínicos randomizados (ECRs) relativos a 1049 pacientes, sendo 474 submetidos a tratamento cirúrgico metabólico e 575 a tratamento clínico isolado, associado ou não a mudança no estilo de vida. O seguimento variou de 12 a 60 meses. Considerações finais: O tratamento cirúrgico metabólico é superior ao tratamento clínico para remissão de DM2 a curto e longo prazo quanto aos benefícios nas condições metabólicas e fatores de risco cardiovasculares. Conduto, essa superioridade está associada principalmentea redução da obesidade, a qual é muito mais intensa no grupo de tratamento cirúrgico.
Estresse ocupacional e fatores desencadeadores na equipe de saúde em unidades de terapia intensiva
Authors: Girardi Letícia Marinheski , Souza Viviane Gisele de , Silva Mauricio de Almeida Pereira da , Silva Junio Cesar da
Published: October 2024

Objetivo: Identificar o nível de estresse ocupacional enfrentado pelos profissionais que atuam em Unidades de Terapia Intensiva e classificar os estressores organizacionais, relacionando-os quanto a sua gravidade. Método: Estudo observacional transversal com abordagem qualiquantitativa realizado em Unidades de Terapia Intensiva de um hospital no Paraná com a equipe multiprofissional. Aplicou-se a Escala de Estresse no Trabalho versão reduzida (EET) e um questionário semi-estruturado. Análise quantitativa foi realizada com dados coletados em Excel e analisados via SPSS, enquanto a análise qualitativa baseou-se no método Bardin para identificar fatores estressantes. Resultados: Contrariando a literatura, a maioria dos profissionais apresentou baixo estresse. Também identificou que profissionais com múltiplos vínculos empregatícios tendem a ter um nível de estresse mais elevado. Fatores como comunicação e relações interpessoais foram relevantes como desencadeadores de estresse nesse ambiente. Conclusão: O estudo destaca a complexidade do estresse ocupacional e a necessidade de pesquisas acerca do tema, visto que impacta diretamente o colaborador e também a empresa empregadora.
Educação permanente em saúde: avaliação de um ciclo de palestras sobre profilaxia do HIV em hospital de referência materno-infantil
Authors: Aragão Ana Nízia da Silva Palheta de , Frazão Andréa das Graças Ferreira , Santos Valéria Regina Cavalcante dos
Published: October 2024

Objetivo: Realizar uma ação educacional para a equipe interdisciplinar, abordando a atualização dos protocolos de profilaxia do HIV e a alta assistida farmacêutica para recém-nascidos, visando avaliar a eficácia do ciclo de palestras e as percepções dos profissionais envolvidos. Métodos: Trata-se de um estudo transversal e descritivo, com abordagem quantitativa e qualitativa, envolveu um ciclo de quatro palestras para uma equipe interdisciplinar de um hospital de referência materno-infantil em Belém. A coleta de dados realizada através de um formulário com 18 perguntas. A análise incluiu distribuição de frequência para dados quantitativos e análise de conteúdo de Bardin para qualitativos. Resultados: O estudo mostrou que a maioria dos participantes avaliou positivamente o ciclo de palestras, destacando o conteúdo como relevante e alinhado às práticas profissionais. A categoria "informações recebidas" foi a mais elogiada, e o domínio dos facilitadores foi amplamente reconhecido. Apesar disso, surgiram sugestões para ajustes na carga horária e inclusão de mais detalhes técnicos. A formação de agentes multiplicadores foi considerada essencial para disseminar o conhecimento nas equipes de saúde. Conclusão: O estudo reforça a importância da educação permanente na capacitação dos profissionais de saúde, contribuindo para a melhoria da assistência neonatal e profilaxia do HIV.
Quadrigeminal plate lipoma presenting with seizures and hydrocephalus in a child – A case report
Authors: Fagundes Walter , Correia Mariana Das Chagas , Dantas Sergio Fernandes , Petry Iago Nathan Simon
Published: October 2024

Background:

Intracranial lipomas are rare, benign lesions with no neoplastic origin. Most affected patients are asymptomatic and are typically pediatric or young adults. We describe a case of a child with a quadrigeminal plate lipoma presenting with seizures and hydrocephalus.

Case Description:

A 6-year-old boy presented with dysarthria, spasticity, gait disturbances, headaches, and seizures. Magnetic resonance imaging revealed a lipomatous lesion in the quadrigeminal cistern with ventriculomegaly. An endoscopic third ventriculocisternostomy was performed for obstructive hydrocephalus, and a biopsy confirmed a lipoma. Over 6 years of follow-up, the patient’s seizures remained controlled, and the lesion remained stable.

Conclusion:

Conservative management with symptomatic control is recommended, given the typically benign progression of lipomas. Seizures are generally well managed with antiepileptic medications. Surgical resection should be reserved for cases where expansive lesions cause significant symptoms or hydrocephalus.
Membangun Konstruksi Sosial Anak Melalui Pendidikan Keluarga Perspektif Al-Qur’an: Analisis Pemikiran Muhammad Hamka dalam Tafsir Al-Azhar
Authors: Adawiyah Robiatul , Rahardja Muhammad Nurfaizi Arya , Hasibuan Ulfah Salwa
Published: October 2024

This research aims to reveal and know the role of family education in building social construction offered by Hamka in Tafsir al-Azhar as an effort to provide solutions to the community regarding the attitude that families need to take in implementing education. This research is qualitative by using library research to obtain research data and is descriptive-applicative. The main source in this research is Tafsir al-Azhar by Hamka and the secondary sources in this research are articles, scientific works, and documents relevant to this research. The results of this study are, first, according to Hamka to justify a society must justify its main joints, namely a person's soul, second, according to Hamka, fathers and mothers have an important role in the family to shape the soul of a child and parents must ensure that they provide good education to children so that children will be able to live social life in society well.
Enhancing social skills: the impact of advanced physical education program development
Authors: Amirudin  , Nurdin Ambia , Zahara  , Nugraha Hendra , Masyitah
Published: October 2024

Background: The cultivation of social behaviour during childhood and adolescence holds paramount importance, serving as a cornerstone for the establishment of robust interpersonal connections in subsequent stages of life, whether transitioning from adolescence to adulthood. Research Objective: This research aims to assess how implementing enhanced physical education influences social interactions and behaviour among adolescents. Methods: The study employed a pretest-posttest control group design, involving experimental and control groups randomly selected from high school students in the City of Aceh. The study’s population was drawn from class X students at a public high school in Aceh City, encompassing 4 classes with a total of 124 students. Cluster random sampling was employed as the sampling technique. The researcher randomly selected one class as the experimental group and another as the control group. The participants included two classes: 30 students from class 10B as the experimental group and 30 students from class 10D as the control group. Thus, the study involved a total of 60 participants. Social behaviour was evaluated using standardised questionnaires measuring various dimensions. The pre-test and post-test data analysis techniques were analysed using a homogeneity test, a normality test, and a Mann-Whitney test using SPSS version 22, with a significance threshold set at p < 0.05. Finding/Result: The results indicate significant improvements in social behaviour among adolescents who underwent the enhanced physical education, sports, and health program compared to the control group. Conclusion: The findings underscore the importance of integrating comprehensive physical education into high school curricula to foster positive social development among adolescents.
Construction d’une clé d’identification des semences de 55 adventices de La Réunion
Authors: Schwartz Marion , Etheve Abel , Bourgeois Thomas Le , Auzoux Sandrine , Christina Mathias , Ripoche Aude
Published: October 2024

Description du sujet. L’identification et la caractérisation des semences d’adventices est un travail indispensable pour de futures recherches sur la compréhension de leur nuisibilité secondaire (capacité des adventices à se disperser dans l'espace et dans le temps). Bien que les adventices soient des bio-agresseurs majeurs en agriculture tropicale, l’identification des semences d’adventices d’espèces tropicales est encore peu étudiée. Objectifs. L’objectif de cette étude est d’élaborer une méthodologie pour identifier les semences d’adventices tropicales à partir de leurs caractéristiques morphologiques. Méthode. Les semences de 55 espèces d’adventices ont été récoltées sur l’île de La Réunion et caractérisées. Une clé d’identification polytomique et d’accès simple a été construite permettant d’aboutir à une identification de l’espèce à partir de la semence. Résultats. La clé d’identification débute par la discrimination des semences par leur forme, puis leur taille et ensuite leur couleur, texture, pilosité ou marques particulières. La clé est publiée au format PDF et inclut des liens hypertextes permettant à l’utilisateur de naviguer dans le document et d’accéder à la fiche descriptive de la semence. La clé est disponible sur le site AGRITROP (archives ouvertes du CIRAD) et sur le portail WIKTROP. Conclusions. Cette clé d’identification constitue la première de son genre pour des adventices tropicales. Elle est destinée à être enrichie au fur et à mesure de nouvelles caractérisations de semences d’adventices tropicales de La Réunion et d’autres régions.
Место России на мировом рынке зерна: проблемы и перспективы
Authors: Е.А. Зайцева , О.Г. Чарыкова
Published: October 2024

Проведена оценка производства зерновых культур в России и мире за 2020–2023 гг. Показано место страны на мировом рынке зерна. Отмечены текущие ключевые внутренние проблемы, сдерживающие производство зерна: высокая ключевая ставка ЦБ РФ, рост производственных затрат, снижение доходности сельхозтоваропроизводителей, изменение направления экспортной логистики и др. 

An assessment of grain production in Russia and the world in 2020–2023 was carried out. The country's place in the world grain market is shown. The current key internal problems restraining grain production are noted: the high key rate of the Central Bank of the Russian Federation, the increase of production costs, the decrease in the profitability of agricultural producers, the change in the in the direction of export logistics, etc.
IN VITRO ASSESSMENT OF PROBIOTIC SURVIVAL IN SIMULATED GASTROINTESTINAL CONDITIONS AND ADHESIVE PROPERTIES
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Zhantlessova Sirina , Sadanov Amangeldy , Baymakhanova Baiken , Orazymbet Saltanat , Ratnikova Irina , Savitskaya Irina
Published: October 2024

The study focused on evaluating the functional properties of four lactic acid bacteria (LAB) strains – Lactobacillus fermentum 30, Lactobacillus cellobiosus 36, Lacticaseibacillus paracasei 36/1, and Lac-ticaseibacillus paracasei 30/1 – and their associations, aiming to assess acid resistance, bile tolerance, enzyme stability, and adhesion capabilities using in vitro methods. The survival rates of these LAB strains and their associations were investigated under simulated gastric juice (SGJ) and simulated intestinal juice (SIJ). In SGJ, the association L. fermentum 30 + L. cellobiosus 36 showed higher survival rates compared to individual strains, with approximately 75% viability after 2 hours incubation. Similarly, the associa-tion L. paracasei 30/1 + L. paracasei 36/1 exhibited enhanced survival in SGJ, maintaining about 80% viability. In SIJ, both associations demonstrated improved survival compared to individual strains, with L. fermentum 30 + L. cellobiosus 36 and L. paracasei 30/1 + L. paracasei 36/1 maintaining approxi-mately 70% and 75% viability, respectively. The adhesion capabilities of these LAB strains and associa-tions were evaluated using human erythrocytes. All strains displayed high adhesive activity, particularly notable in L. paracasei 36/1 + L. paracasei 30/1, which demonstrated a significantly higher adhesion index compared to other strains. These findings highlight the robust survival and adhesive properties of the LAB strains and their associations under simulated gastrointestinal conditions. Further research is warranted to explore their potential applications in promoting gut health and combating gastrointestinal disorders.
Colangiocarcinoma intra-hepático em coelho (Oryctolagus cuniculus Linnaeus, 1758) no semiárido potiguar: relato de caso
Authors: Sousa Ana Caroline Freitas Caetano de , Diniz João Augusto Rodrigues Alves , Lopes Igor Renno Guimarães , Santos Wanderson Lucas Alves dos , Praciano Raimundo Marcel Gomes , Maia Ana Carolina Souza , Santos Maria Danielle Chagas dos , Oliveira Moacir Franco de , Freitas Carlos Iberê Alves , Braga Juliana Fortes Vilarinho
Published: October 2024

Colangiocarcinoma é um tumor maligno considerado raro em animais e apresenta prognóstico desfavorável. Neste relato descreveu-se o primeiro caso documentado de colangiocarcinoma em coelho (Oryctolagus cuniculus). O animal, de seis anos de idade, apresentava histórico de incoordenação há sete dias. No exame físico, o coelho apresentava-se desidratado e com reflexos diminuídos, sendo iniciado suporte de emergência e, após 24 horas, o animal veio a óbito. À análise anatomopatológica foi observado fígado diminuído de volume, com superfície difusamente irregular com áreas esbranquiçadas a branco-amareladas multifocais, além de áreas avermelhadas. Ao corte, o órgão apresentava consistência firme. Fragmentos do órgão foram coletados para análise histopatológica, a qual revelou proliferação de células neoplásicas com características morfológicas compatíveis com colangiocarcinoma. O parênquima remanescente encontrava-se desorganizado, com áreas de fibrose, degeneração e necrose. Este relato evidencia a necessidade de inclusão do colangiocarcinoma como diagnóstico diferencial em casos de patologias hepáticas com ou sem sinais clínicos neurológicos em coelhos. Sendo este o primeiro relato da neoplasia nesta espécie, os dados apresentados podem contribuir para elucidação de futuros estudos e casos clínicos.
Avaliação ultrassonográfica ocular em modo – B de cães com catarata
Authors: Pereira Marina Cavalcanti , Silva Elayne Cristine Soares da , Pohle Ana Paula Vieira Barbosa , Spinelli Taciana Pontes , Evêncio Neto Joaquim , Sá Fabrício Bezerra de
Published: October 2024

A catarata é uma das principais afecções que causam cegueira nos cães. Devido à opacidade do cristalino, ocorre a dificuldade ou mesmo a não visualização de estruturas presentes na câmara vítrea, degenerações e hemorragias. Com isso, a ultrassonografia ocular torna-se uma ferramenta importante para essa avaliação das estruturas oculares. Objetivou-se com esse trabalho realizar a ultrassonografia ocular em cães de diversas raças, idades e graus de desenvolvimento da catarata com o intuito de avaliar a presença da degeneração vítrea (DV), condições do cristalino, localização da opacidade, posicionamento da retina, suas relações e outras alterações que prejudiquem o pós-cirúrgico ou impeçam a realização da facectomia. Um total de 31 animais participaram do estudo, no qual 57 olhos foram examinados. A raça predominante foi a Poodle, com 45,16% (14/31) dos cães avaliados. A idade variou de 2 a 16 anos, 48,4% (15/31) eram machos e 51,6% (16/31) fêmeas. Quanto à DV, 19,29% (11/57) dos bulbos oculares apresentavam grau zero; o mesmo quantitativo foi encontrado nos graus 1 e 2 com 35,8% (20/57) cada e, no grau 3, 10,52% (6/57). Em 12,56% (7/57) havia hialose e em 3,5% (2/57) descolamento parcial da retina. Após a análise dos dados não foi possível observar uma correlação entre a catarata e a DV, bem como o grau de DV e a idade dos animais.
Ácido Trans-ferúlico na maturação in vitro de zigotos ovinos
Authors: Lima Andreza Mayara Carneiro de , Oliveira Luana Kealy Pimentel de , Aureliano Érika Karoline de Oliveira , Santos Damaris Raquel Pires dos , Freitas Beatriz  Cavalcanti de , Souza William Matheus , Silva Jossimara de Melo , Pereira Ailton Batista , Lima Sueli de Oliveira , Lopes Isabela Maria , Silva Bruna Moura , Souza Thaís Thatiane dos Santos , Cordeiro Mabel Freitas , Lopes Júnior Edilson Soares
Published: October 2024

O objetivo desse trabalho foi avaliar o uso do ácido trans-ferúlico (ATF) na maturação in vitro de oócitos e na produção in vitro de embriões ovinos. Para isso, oócitos foram divididos em cinco grupos de tratamento: o grupo controle (CON), no qual oócitos foram imersos em meio sem utilização de antioxidantes, já no grupo cisteamina (CIS), os oócitos foram inclusos no mesmo meio do grupo CON, mas contendo 100µM de cisteamina como fonte antioxidante; nos grupos ATF10, ATF50 e ATF100, os oócitos foram inclusos no mesmo meio do grupo CON, mas contendo 10µM, 50µM e 100µM de ácido trans-ferúlico, respectivamente. A maturação in vitro (MIV) foi realizada por 24h, a 38,5°C, com 5% de dióxido de carbono (CO2). Em seguida, foi realizada a fecundação in vitro (FIV), seguido de cultivo in vitro (CIV) dos presumíveis zigotos, o qual ocorreu em meio fluido sintético de oviduto (SOF) com 2mg/mL de albumina sérica bovina (BSA), sendo avaliada a taxa de estruturas clivadas após 48h de cultivo. Os dados foram apresentados em porcentagem e foi utilizado o teste de Qui-quadrado no software Epi Info®. Os resultados foram considerados significativos quando p?0,05. Foi possível observar que em relação a taxa de expansão o AFT100 se mostrou superior ao ATF10, CIS e CON (95,3%; 76,7%; 79,1%; 81,4%). Para grau de expansão das células do cumulus, número de presumíveis zigotos e número de estruturas clivadas, não houve diferença significativa entre os grupos com ácido trans-ferúlico (ATF10, ATF50 e ATF100) e cisteamina (CIS). Sendo possível concluir que o ácido trans-ferúlico é uma alternativa à cisteamina como agente antioxidante no meio de maturação in vitro de oócitos ovinos.
Miíase gástrica visualizada por endoscopia em equino: primeiro relato de caso no estado de Pernambuco, Brasil
Authors: Vieira Catharina de Albuquerque , Da Silva Carolina Jones Ferreira Lima , Trindade Keity Laiane Gomes , Manso Helena Emilia Cavalcanti da Costa Cordeiro , Manso Filho Hélio Cordeiro
Published: October 2024

O parasitismo por insetos, como as miíases, é um problema significativo para os equídeos, podendo comprometer a sua saúde, comportamento e desempenho. A larva do gênero Gasterophilus é o agente causador de miíase gástrica e afeta equídeos. Objetivou-se descrever o primeiro registro de um caso de miíase cavitária no estômago de um equino no Nordeste do Brasil, visualizada por endoscopia. Um equino, macho, adulto, foi submetido à gastroscopia, hemograma e três testes seriados de sangue oculto nas fezes. Na endoscopia foi visualizada larva compatível com o gênero Gasterophilus, o que representa um achado inédito na região. O animal apresentava úlceras na porção aglandular do estômago, apresentou leve anemia ao hemograma e presença de albumina e hemoglobina nas fezes. É importante que se mantenham programas de controle de parasitos em criações de equídeos, principalmente devido à dificuldade de diagnóstico a campo de enfermidades como a gasterofilose, que podem afetar o bem-estar desses animais.
Compendio Memorias de Investigación. II Encuentro Virtual de Investigadores de Posgrado
Authors: Bravo Gómez David Mauricio , Mercado Lisbeth del Carmen , Huertas Bustos Adriana Patricia , Acosta Acosta Sayly Julieth , Baquero Celeita Fabio Nelson , Castiblanco Carrión Nataly , Navarro Pua Osirys Isabel , Sepúlveda del Rio Cielo , Soto Torres Lida Cristina , Esparza Gutiérrez Luisa Fernanda , González Rincón Laura , Quimbayo-Feria Adriana , Díaz Quintana Lisseth Dayana , Villamizar Rodríguez Nasly Seleny , Pardo Yela Sandra Patricia , Tobar Ceballos Jorge Armando , Zabala Vargas Sergio Andrés , Bustamante Matoma Harold Anderson , Zarta Rojas Fabian Andrey , Avendaño Quintana Juan Antonio
Published: October 2024

En el marco de la sociedad del conocimiento, la investigación es uno de los pilares para alcanzar los f ines de la modernidad. Es desde ella como se puede lograr una actitud emancipadora, enmarcada en el conocimiento, y dar forma a una interpretación objetiva de la realidad. En esa dinámica, la formación científica en el nivel de estudio posgradual es uno de los espacios académicos de mayor importancia para el desarrollo de competencias conceptuales, teóricas y empíricas. Aproxima a los investigadores en formación a la apropiación de la ciencia, sus paradigmas, enfoques y técnicas que, de manera fiable, les permiten interpretar, comprender y apropiar los fenómenos disciplinares. En Colombia, el desarrollo de talento humano en investigación desde la formación posgradual es de gran importancia para potenciar el desarrollo del país. En esa medida, son múltiples los esfuerzos que las universidades realizan desde su oferta académica, en especial, en los niveles de maestría y doctorado, para desarrollar en sus estudiantes un perfil profesional con sólidos conocimientos y práctica en investigación. El II Encuentro Virtual de Investigadores de Posgrado, organizado por la Rectoría Virtual de la Corporación Universitaria Minuto de Dios - UNIMINUTO, fue un espacio académico de gran valor para propiciar la divulgación y el diálogo académico alrededor de las investigaciones que las universidades adelantan en sus programas de posgrado.
Effect of celecoxib and paracetamol on the functional state of the central nervous system, pain sensitivity, and physical endurance of rats with acute heat injury
Authors: Chuikova P.O. , Shtrygol’ S.Yu.
Published: October 2024

Acute heat injury (AHI) is a serious condition caused by an excessive increase in body temperature, usually due to prolonged exposure to high environmental temperatures or intense physical activity in the heat. Without timely treatment, heat stroke can lead to severe damage to the central nervous system with cerebral edema, profound disturbances in the water-salt balance and internal organs, coma and death. Since the effectiveness of drugs for the treatment of thermal injuries has not been proven, the search for new thermoprotective agents with different mechanisms of action, in particular inhibitors of the arachidonic acid cascade, is urgent. In a preliminary screening study on the AHI model in rats, it was found that among cyclooxygenase (COX) inhibitors, the highly selective COX-2 inhibitor celecoxib and the analgesic-antipyretic para­cetamol are the most effective in preventing hyperthermia and improving the course of the recovery period. The purpose of this study was to determine the impact of the specified screening leaders on the functional state of the central nervous system, pain sensitivity and physical endurance in the recovery period of heat injury. The AHI model was reproduced on adult white male rats according to the previously proposed and validated method by means of a 30-minute exposure at +55°C. Animals were divided into 4 groups with 8 rats in each group: intact control, control pathology, paracetamol group and celecoxib group. Based on the results of the study, it was established that celecoxib exhibits a pronounced thermoprotective effect, probably improves the state of the central nervous system in terms of behavioral reactions and physical endurance of animals in the recovery period after acute heat injury. At the same time, paracetamol after acute heat injury does not have a distinct positive effect on the functional state of the central nervous system, moderately improves the physical endurance of rats and is inferior to celecoxib in all the studied parameters. These results open new opportunities for the development of approaches to the treatment of AHI and confirm the different effectiveness of the use of celecoxib and paracetamol in thermal injuries.
Modern views on the etiology and role of microbial persistence in the development of inflammatory processes in the periodontal complex (review)
Authors: Marfiian O.V. , Demkovych A.Ye. , Bondarenko Yu.I. , Yaremchuk O.Z.
Published: October 2024

Alveolar tissue diseases cause the appearance of dentition defects, thereby reducing the patients' work capacity and quality of life. The purpose of this research was to investigate, modern views on the etiology of periodontitis and the role of microbial persistence in the development of inflammatory processes of periodontal complex basing on a review of literary sources. Literature review was conducted using PubMed, Web of Science, Scopus, Google Scholar from 2018 to March 2024. There were no restrictions on the date of publication or the language of scientific sources. Searches were conducted according to MeSH (Medical Subject Headings) with using the following search terms: "periodontitis", "oral mucosa", "gums", "dental plaque", "periodontium", "traumatic occlusion", "microorganisms". In total, during the initial analysis 82 literary sources were selected and processed, after further systematization of the selected information using general scientific methods, 70 of them remained. Used methods: bibliographic and analytical. Generalized perio­dontitis is a chronic inflammatory-dystrophic process that occurs as a result of various factors. In the pathogenesis of this disease, the key role is played by the inflammatory process, which is a complex interaction of microcirculatory, he­matological and connective tissue reactions to the lesion. Local (exogenic) and general (endogenic) causative factors are distinguished. The main factors that cause pathological changes in periodontium are bacterial biofilm, traumatic occlusion and various anatomical anomalies. Dental plaque occupies a special and main place among the causes of periodontitis. At present, leading pathogenetic links in the development of the inflammation in the periodontium, in par­ticular, the disruption of free radical oxidation, the processes of peroxide oxidation of lipids and proteins, the disorder of the functional state of the antioxidant system, the formation of oxidative stress, as well as the humoral link of adaptive immune protection and cytokinesis, have not been sufficiently studied. There is no doubt about the role of the microbial factor in the etiology of periodontal diseases, but the penetration of microbes into the periodontium does not always lead to the development of the disease, because the organism has a number of protective mechanisms that counteract the development of inflammation.
Gender-associated features in diabetic kidney disease
Authors: Safarova S.S.
Published: October 2024

Diabetic kidney disease (DKD) is the leading cause of end-stage renal failure. Evidence indicates gender differences in the progression of this disease. This study aimed to determine gender differences in prevalence and identify gender-associated risk factors contributing to the development of diabetic kidney disease in individuals with type 2 diabetes mellitus (T2DM). The cross-sectional study included 132 patients with T2DM ranging in age from 50 to 65 years. Subjects were stratified by sex (80 women and 52 men). Gender differences have been studied in relation to the incidence and prevalence of DKD, their phenotypes and clinical manifestations, and several risk factors that have different effects on both sexes. The outcome of clinical kidney function assessment showed that 70% subjects were diagnosed with DKD (71% of women and 67% of men). The study indicated an association between the duration of T2DM and urinary albumin levels, as well as between arterial hypertension and triglyceride levels, which are independent risk factors for DKD development. Notably, older women with T2DM have a higher prevalence of DKD than older men. The albuminuric component of DKD was more frequently observed in men. Additionally, men were more likely to have adverse risk factors, including dyslipidemia, lower high-density lipoprotein cholesterol, and glomerular filtration rate, which are factors involved in the mechanisms of DKD. In summary, the results indicate that: 1) women with type 2 diabetes mellitus are at a higher risk of developing a normoalbuminuric phenotype of diabetic kidney disease, while men are at a higher risk of developing an albuminuric phenotype of diabetic kidney disease leading to renal failure and end-stage renal disease; 2) gender differences are most noticeable among older adults and may have significant implications for the development of more effective diagnostic and treatment methods for diabetic kidney disease, tailored to individual needs.
Transcranial electrical stimulation in post-traumatic stress disorder and brain injury: possibilities of tuning neuronal networks
Authors: Smashna O.Y.
Published: October 2024

Transcranial direct current stimulation (tDCS) in the treatment of post-traumatic stress disorder (PTSD) is used to strengthen the inhibitory control of amygdala activity. However, there are still limited meta-analytic studies examining different tDCS protocols on core PTSD symptoms and the relationship between stimulation parameters and effect size. The objective is to investigate the effectiveness of such an intervention, which is a complex combination of a psychotherapy program with tDCS in the treatment of patients with PTSD and mild traumatic brain injury (mTBI) by assessing their level of functioning. 329 veterans (PTSD (n=109), mTBI (n=112), PTSD + mTBI (n=108) were examined using WHODAS 2.0. Standardized treatment was provided as well as psy­chotherapeutic intervention - a combination of psychoeducation with motivational interviewing and acceptance and commitment therapy for PTSD and tDCS. Clinical targets of therapy in the PTSD group were symptoms of intrusion, avoidance, hyperactivation and protocol of tDCS was dorsolateral prefrontal cortex arousing stimulation. In PTSD + TBI group clinical targets were neurocognitive symptoms, intrusion symptoms, avoidance, hyperactivation and tDCT protocol was motor cortex-supraorbital area inhibitory stimulation. The targest for TBI group was neurocognitive symptoms and tDCS protocol was occipital region exciting stimulation. The long-term effectiveness and the impact on neuroplasticity processes allow considering transcranial direct current stimulation as a promising method of neurorehabilitation of patients with a combination of posttraumatic stress disorder and mild traumatic brain injury.
МЕТОДЫ ИНСТИТУЦИОНАЛЬНОГО СТИМУЛИРОВАНИЯ МОДЕЛИ ГОСУДАРСТВЕННО-ЧАСТНОГО ПАРТНЕРСТВА В УСЛОВИЯХ ТЕРРИТОРИЙ ОПЕРЕЖАЮЩЕГО СОЦИАЛЬНО-ЭКОНОМИЧЕСКОГО РАЗВИТИЯ
Authors: АЛИБИЙ ФЕДОР МИХАЛЫЧ , САБАНЧИЕВ АНЗОР ХУСЕЙНОВИЧ
Published: October 2024

В статье рассматриваются методы институционального стимулирования модели государственно-частного партнерства в условиях формирования территорий опережающего социально-экономического развития. В ходе подготовки статьи был использован комплекс аналитических и дескриптивных методов. В результате анализа модели государственно-частного партнерства полученные результаты позволили определить, что расширение модели территорий опережающего социально-экономического развития и ее активизация требуют разработки стимулов повышения эффективности в силу того, что наблюдаемое постепенное снижение эффективности формирует своеобразный «эффект затухания». В этих условиях использование так называемых административных методов, а также традиционных стимулов, основанных на расширении разного рода преференций, создает лишь временные всплески в виде «шоков предложения», не вызывая соответствующих «шоков спроса». Представляется, что новым направлением, позволяющим активизировать технологические и хозяйственные процессы в модели ТОСЭР, может стать государственно-частное партнерство. Полученные в статье выводы позволили выявить, что инкорпорирование государственно-частного партнерства в территориях опережающего социально-экономического развития должно содержать несколько базисных условий: во-первых, не дублировать уже существующие инструменты государственного регулирования и поддержки; во-вторых, создавать на каждом этапе локальные мультипликативные эффекты, которые могли бы быть агрегированы в общий устойчивый тренд. В статье делается попытка представить последний аспект через институциональные продукты.