bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioxidant and Antitumor Properties of Wild Blueberry (Sideroxylon mascatense)
Authors: Al Hasani Shaima , Al-Attabi Zahir Humaid , Waly Mostafa , Rahman Mohammad Shafiur , Tamimi Yahya
Published: February 2021

Background:

Sideroxylon mascatense is a wild blueberry plant that traditionally known as “boot” in Oman. Studies on health beneficial effects of this fruit are very limited.

Aims and Objectives:

This study aimed to evaluate the antioxidant and antitumor properties of Sideroxylon mascatense under different drying methods.

Materials and Methods:

Freeze (−20°C) and air drying (60 and 90°C) methods were used. The antioxidant potential properties were evaluated using DPPH and ABTS assay. Moreover, the antitumor activities of blueberry extracts were determined using Alamar blue assay.

Results:

The results of this study revealed that a blueberry extract at 20 mg powder/mL provided the maximum amount of vitamin C, reaching a value of 19.45 mg/100 g dry-basis in the flesh dried at 60°C and 14.24 mg/100 g dry-basis in seed dried at 90°C. The freeze-dried blueberry exhibited the highest percentage of free radical scavenging activity (DPPH) from both fruit flesh (50.8%) and seeds (39.4%) at a concentration of 20 mg/mL indicating a higher antioxidant activity. There was no significant difference in the ability of blueberry extracts to scavenge radical cations (ABTS+) at various concentrations of extracts. However, there was a 40% reduction of ABTS+ radical formation in blueberry flesh extracts obtained from freeze-dried berry at a concentration of 20 mg/mL. On the other hand, blueberry seeds showed variation in the scavenging activity of the ABTS+ radical of 38% after different processing methods. Breast MCF7 and ovarian Ov2008 tumor cell lines were the most sensitive to the dried blueberry. The 50% growth inhibition (IC50) of the freeze-dried blueberry extract at both cell lines was 64 and 69 μg/mL, respectively.

Conclusion:

Our findings indicated a potent antioxidant activity of Sideroxylon mascatense, but further research is required to isolate the active compounds in the fruit and test their effects in an experimental animal model.
Hepatitis B virus infection-related knowledge, attitude, and preventive practices among market traders in Lagos, Nigeria - A cross sectional study
Authors: Adejimi Adebola A. , Bakare Adeyinka A. , Ogunyemi Adedoyin O. , Adewole Ajoke M.
Published: February 2021

Background:

Hepatitis B virus (HBV) is highly infectious and a major cause of morbidity and mortality. Prevention of HBV infection can be achieved through safe practices and immunization. The objectives of this study were to assess knowledge, attitude, and preventive practices for HBV infection among market traders in Lagos State, Nigeria.

Methods:

A descriptive, cross-sectional study involving 417 market traders in Somolu Local Government Area of Lagos State selected by multistage sampling technique was conducted. A pretested interviewer-administered questionnaire was used for data collection. Data analysis was done using Statistical Package for the Social Sciences version 20. Chi-square statistics was used to test the association between variables, and the level of significance was set at 5%.

Results:

The mean age of the respondents was 39.2 ± 12.5 years. About 64% were female, 69.8% were married, and only 15.6% had tertiary education. Majority (97.6%) were aware of HBV infection. Overall, about 80% of the respondents had good knowledge of HBV infection, while 51.8% had good attitude toward HBV prevention, but only 18.5% of them had good preventive practices toward HBV infection. Only 5% of the respondents had completed the three doses of hepatitis B vaccine. Knowledge and preventive practices of the respondents about HBV infection were significantly associated with the level of education and marital status, while attitude to the preventive practices was associated with gender. Respondents' knowledge and attitude were significantly associated with the preventive practices for HBV infection.

Conclusion:

There is a need to target the traders in the markets and create appropriate awareness, screening, and vaccination programs for the prevention of HBV infection.
Integrating genomics education into Nigerian undergraduate medical training - A narrative review
Authors: Afolaranmi Oluwasegun Joshua , Salako Omolola , Okunade Kehinde S. , James Ayorinde B. , Fagbenro Gabriel T.
Published: February 2021

Nigeria, as well as other low- and middle-income countries, still lags significantly behind in the development, understanding, and application of genomics-based approaches in the diagnosis and treatment of diseases. To close this gap, and to enjoy the monumental opportunities of genomics and precision medicine, training and education in genomics must become a priority and must commence early enough in medical training. This article presents a synopsis of the development of genomics, the current state of genomics research and education with a focus on Nigeria and importantly, provides critical suggestions on how best to integrate genomics into undergraduate medical training in Nigeria. There is no doubt about the need to prepare Nigerian physicians to be able to tap adequately into the countless opportunities of the genomics era. As a matter of urgency, steps must be taken to introduce carefully designed, unified and competency-based genomics training module based on sound pedagogy into the Nigerian medical undergraduate curricula.
Estimating the Fraction of Severe Malaria among Malaria-Positive Children: Analysis of Household Surveys in 19 Malaria-Endemic Countries in Africa
Authors: Taylor Cameron , Namaste Sorrel M. L. , Lowell Joanna , Useem Johanna , Yé Yazoumé
Published: February 2021

To date, the only robust estimates of severe malaria cases include children who present to the formal healthcare system. It is a challenge to use these data because of varying age ranges of reporting, different diagnosis techniques, surveillance methods, and healthcare utilization. This analysis examined data from 37 Demographic and Health Surveys and Malaria Indicator Surveys across 19 countries in sub-Saharan Africa collected between 2011 and 2018. The outcome of interest is a proxy indicator for severe malaria, defined as a proportion of children aged 6–59 months with at least one self-reported symptom of severe illness including loss of consciousness, rapid breathing, seizures, or severe anemia (hemoglobin < 5 g/dL) among those who were positive for malaria. The study includes a weighted descriptive, country-level analysis and a multilevel mixed-effects logistic regression model to assess the determinants of severe malaria. Among children positive for malaria across all surveys, 4.5% (95% CI: 4.1–4.8) had at least one sign or symptom of severe malaria, which was significantly associated with age, residence, wealth, and year of survey fieldwork at a P-value less than 0.05. This analysis presents a novel and an alternative approach of estimating the fraction of severe malaria cases among malaria-positive children younger than 5 years in malaria-endemic countries. Estimating severe malaria cases through population-based surveys allows countries to estimate severe malaria across time and to compare with other countries. Having a population-level estimate of severe malaria cases helps further our understanding of the burden and epidemiology of severe malaria.
Manifest der Künstlerischen Forschung
Authors: Henke Silvia , Mersch Dieter , Strässle Thomas , Wiesel Jörg , van der Meulen Nicolaj
Published: February 2021

Seit ihren Anfängen in den 1990er Jahren hat sich »künstlerische Forschung« als ein neues bildungs- und institutionenpolitisches wie auch ästhetisch-kunsttheoretisches Format etabliert. Inzwischen ist sie auf fast alle künstlerischen Felder diffundiert: von der Installationskunst über experimentelle Formate bis zur zeitgenössischen Musik, der Literatur oder Tanz- und Performancekunst. Doch steht sie seit ihrem Beginn – etikettiert unter Labels wie »Kunst und Wissenschaft« oder »Scienceart« und »Artscience«, die beide in einem Atemzug miteinander verbindet – im Wettstreit mit der akademischen Forschung, ohne dass ihr eigener Forschungsbegriff angemessen geklärt wäre. Das Manifest unternimmt den Versuch, Klärung zu schaffen und den Begriff, die Potenziale und Radikalität einer forschenden Kunst gegen diejenigen zu verteidigen, die allzu vorsichtig mit universitären Formaten liebäugeln und sie an wissenschaftliche Prinzipien anschließen wollen. Vielmehr geht es darum, die Eigenständigkeit und besondere Intellektualität ästhetischen Forschens herauszustreichen, ohne Legitimitätszwängen zu genügen und fremde Maßstäbe anzulegen. Die Publikation ist versetzt mit »Bildstücken« – Deklination einer Collage von Sabine Hertig (2019).
Improving Senior High School Students’ Physics Problem-solving Skills Through Investigated Based Multiple Representation (IBMR) Learning Model
Authors: Setyarini Dyah Ayu , Imam Supardi Zainal Arifin , Elok Sudibyo
Published: February 2021

This research aims to improve senior high school students’ physics problem-solving skills through learning used IBMR learning model. This research was a pre-an experimental study with a one-group pre-test and post-test design. The Methods of data collection used validation and test. The materials used to teach were valid category by two experts and can be used to practice physics problem-solving skills. The average post-test score physics problem-solving ability was 73.24 with an N-gain of 0.59 was classified as moderate. The success of IBMR learning model-based devices in practicing problem-solving abilities can be seen in the increase in the average score in each indicator of problem-solving abilities. The indicator of understanding the problem had the highest post-test average score of 94.58 with an N-gain of 0.89 in the high category. The problem-solving indicator had the lowest posttest average score was 58.22 with N-gain 0.39 and mean that it was the moderate category. Based on the results study, it can be concluded that the learning used by IBMR learning model can practice the ability to solve physics problems on heat material and its displacement. Learning with the IBMR learning model was expected to train students in solving physics problems. The stages in the IBMR learning model can help students
Design of Learning Activities using Rigorous Mathematical Thinking (RMT) Approach in Application of Derivatives
Authors: Dayat Hidayat  , Ahmad Wachidul Kohar  , Nina Rinda Prihartiwi  , Husni Mubarok  , Abebayehu Yohannes
Published: February 2021

Learning design is one of the factors that support the learning process in order to achieve learning objectives in all subjects including mathematics. Many approaches can be employed by a teacher in making learning design, one of which is rigorous mathematical thinking (RMT) approach. The RMT approach puts forward students actively in constructing their knowledge through the use of psychological tools and mediation. This article reports a set of learning activities designed through a developmental study using the RMT approach in the topic of application of derivatives. Participants of this research were twenty-six of 11th grade students from a private secondary school. Data were collected through written test and classroom observation. The research instruments were student worksheet and observation sheet. In the learning process, students use psychological tools to connect their previous knowledge to the material being studied. This makes students able to construct their own knowledge more thoroughly. On the other hand, with the mediation carried out by the teacher, students can focus more and understand each material well and bridge the conceptual errors. Based on the results of the study and some literature, Design of learning activities using Rigorous Mathematical Thinking (RMT) on application of derivative can be an alternative as effective learning.
The Rise of E-Learning in COVID-19 Pandemic in Private University: Challenges and Opportunities
Authors: Daniel Hermawan
Published: February 2021

The COVID-19 pandemic which is occurring all over the world indeed has many negative impacts in various aspects. On the other hand, the COVID-19 pandemic aroused the use of e-learning which has been seen as a complementary medium in the education process in Indonesia. This research aims to explore the challenges and opportunities felt by students in private university by implementing e-learning as an innovative learning method in the future. Through the mixed method approach, it can be concluded that e-learning can be accepted as an educational solution in dealing with the COVID-19 pandemic, but it still requires improvements in terms of comfort, infrastructure, and absorption of knowledge so that e-learning does not merely move classrooms into digital classrooms, but also provides a holistic experience that makes it easier for students to learn and gain knowledge. Research provide student perspectives in undergoing e-learning which is expected to be a recommendation for universities to provide a good e-learning experience. In addition, there is an evaluative step for the lecturer in optimally optimizing e-learning design.
The Implementation of the Quantum Teaching Strategy with Multiple Intelligence Approach at State Senior High School
Authors: Basuki Tri Harnoto  , Rahyu Setiani  , B Widuroyekti  , Dwi Sambada  , Dwikoranto  , Lindsay N. Bergsma
Published: February 2021

The purpose of this research was to improve student learning outcomes, activities, and positive responses. Classroom action research carried out in 4 stages: planning, action and observation, reflection, and revision that carried out in three cycles. Data were collected through test, observation, questionnaire, and documentation. The participants of this research are class XI-3 students of State Senior High School 1  Krembung. Data were analyzed descriptively quantitative. Observation cycle 1, motivation by the teacher, learning objectives, explanation of working on worksheets, worksheet systematics, class control, seating settings, and intelligence use are lacking. The mean obtained is 55 with grade completeness of 38%. Observation cycle 2, delivery of learning objectives hastily, connecting material with daily phenomena is less clear, concluding that the material is not systematic. However, many students begin to maximize their intelligence to obtain a mean 63.75 with class completeness of 60%. Observation cycle 3 shows an improvement, and the process runs smoothly so that the mean is 74 with grade completeness 81%. Students' positive activity increased from cycle I to cycle III while learning achievement from cycle one to cycle three increased respectively by 38%, 60%, and 81%. The student’s response questionnaire showed that students had a positive attitude with 81.73% and 18.27% negative. In conclusion, student achievement and activity in learning had increased and received a positive response.
Analysis of Learning Quality With Internet-Based Distance Learning During the COVID-19 Pandemic
Authors: Nugroho Yuli Sutoto , Anifah Lilik , Sulistiyo Edy , Cahyaningtias Sari , Rifqi Firmansyah
Published: February 2021

Analysis of the quality of learning is crucial in the teaching and learning process, to ensure the quality of learning is well maintained. Learning quality assurance instruments are one of the tools to improve quality in education through evaluations produced by studies of students. This research was conducted to test the quality of online learning during the COVID-19 pandemic. This research aims to evaluate Internet-Based Distance Learning which was carried out during the Work From Home (WFH) period. The learning analysis step is carried out through 1) Formulation of the need for quality analysis of learning, 2) Compiling quality analysis instruments, 3) Distribution of questionnaires, 4) Data processing, 5) Data analysis and 6) Compilation of results. The data analysis technique used descriptive qualitative analysis. The data that has been processed will then be analyzed using descriptive qualitative methods to find conclusions about the quality of learning in the Department of Electrical Engineering (JTE) during the 2020 pandemic. From the analysis, results obtained information that the Quality of Learning with Internet-Based Distance Learning during the COVID-19 Pandemic at JTE it can be said that it is good from a student's point of view, while from a lecturer's point of view, It can be concluded that online learning is very good. The implementation of this research is a consideration for JTE to improve the quality of Internet-Based Distance Learning
Organizational Identification: Exploring the use of Training as an Employee Identification Marker in SMEs
Authors:   , Adekunle Adetola
Published: February 2021

Organizational identification (OI) is a fundamental organizational behavioural concept in business that influences employee belongingness with the organization, this study identified two key categories of factors (employee and organizational) that influence the employee OI process within SME- known as OI markers. The first category- employer situational-context markers are factors influencing employees’ OI process that employees do not have implementation control over but only experience and react to, such as vertical communication. The second category- employee situational-gap markers however include factors such as employees’ sense of in-company worth which are often cognitive and affective notions employees can control within SMEs. More specifically, emphasis was laid on ascertaining what role(s), training interventions, as a strategic human resource development (HRD) tool, play in influencing the employee OI process and thus the OI statuses of employees in SMEs within the UK. A conceptual OI framework was developed to facilitate the investigation using Dervin (1999) and Weick’s (1993) sense-making theories. The interpretative phenomenological analysis (IPA) method of analysis was employed for this exploratory study, using data from fifteen SME employees’ semi-structured interviews within the retail, health and social care, information and communication technology, financial and food industry of the UK economy. Training interventions emerged as a dual-role OI marker, with the research outcome proposition that employee OI statuses in SMEs occur as a vector component with both magnitude and directional attributes facilitated by employer situational-context and employee situational-gap markers. Specifically initiated and facilitated training interventions playing the roles of employer situational-context and employee situational-gap OI markers respectively. The identified vector quality of OI statuses further enhances the body of OI literature concerned with the non-static behaviour of employees OI status, as these can fluctuate between the two extremes of employee organizational disidentification or identification (EOD or EOI). An OI framework is proposed with which SMEs organizations could justifiably adjust their policies and procedures to imbue employees with a stronger sense of belongingness or OI status within their establishments.
Educación en tiempos del COVID-19, perspectiva desde la socioformación.
Authors: Cevallos Uve Gabriel Estuardo , Cedeño Hidalgo Enma Rocío , Sánchez Ramírez Verónica Beatriz , Macas Moreira Katherine Marisol , Ramos López Yordenis
Published: February 2021

La pandemia de COVID-19 se convirtió repentinamente en una prueba inmensa para los sistemas de educación de todos los países. Este punto de vista desembocó en orientaciones a comunidad educativa para atender la emergencia. Reanimar las actividades educativas con los estudiantes y maestros considerando sus situaciones familiares como componente indispensable al implementar la capacidad de educar de forma remota, con el uso de plataformas digitales de forma prioritaria. En la investigación documental se identifica de alguna forma el enfoque socioformativo para enfrentar la emergencia en lo posterior, mientras se construyen programas educativos adaptados, la planificación debe centrarse en las necesidades del entorno, la realidad del estudiante, del docente, su familia y que hacer una vez que la pandemia haya finalizado.
Conciliación familia-trabajo y su relación con la salud mental y el apoyo social desde una perspectiva de género.
Authors: Pérez Ramos Sara Paola
Published: February 2021

La incapacidad de conciliar la vida laboral y familiar (especialmente difícil para las mujeres) tiene efectos en la salud mental. Se realizó una investigación con los objetivos de 1. Analizar cómo se relaciona la conciliación con la salud mental (síntomas somáticos, disfunción social, ansiedad e insomnio y depresión) y con el apoyo social (emocional/informacional, afectivo e instrumental) y 2. Analizar las diferencias por sexo. Se analizó una muestra de 928 trabajadores de la zona Puerto Vallarta-Bahía de Banderas. Como resultados están que 1. Existe una relación negativa entre conciliación y síntomas de baja salud mental, 2. Hay una relación positiva y significativa entre conciliación y apoyo social, y 3. Las mujeres muestran mayores medias en síntomas de baja salud.
Métodos para lograr la hipertrofia muscular en adultos de 50 a 60 años de edad.
Authors: Copado Estrada Alan Israel
Published: February 2021

La hipertrofia muscular es el resultado del entrenamiento de fuerza de mediana intensidad y alto volumen, sumado a una selección correcta de un método de entrenamiento. En el presente trabajo se compararán métodos de entrenamiento destinados a la hipertrofia muscular en adultos de 50 a 60 años de edad. El objetivo es comparar cuál de los métodos resulta más conveniente a la hora de entrenar mediante la recopilación de información llevada a cabo, así como sustentada, de la misma forma, evaluar sus ventajas y desventajas de cada uno de ellos y cuál es mejor dependiendo las características con base en ello. El tipo de estudio es de carácter documental comparativo, pues se buscará recompilar información sobre el tema investigado.
La sororidad como vía para la formación docente en mujeres.
Authors: García García Nely
Published: February 2021

En el presente trabajo se plantea sensibilizar e implementar en la comunidad educativa la estrategia de formación docente continua basada en la estrategia de sororidad, como una acción que contribuye a la mejora de la práctica de las docentes dentro de la educación media superior. Es preciso sensibilizar a las instituciones educativas a cerca de la necesidad de la formación docente continua de las docentes, sobre todo el crear redes de sororidad entre mujeres para que continúen con su formación profesional.
Heritage Language Literacy: Theory and Practice
Authors: Chevalier Joan F.
Published: February 2021

This paper analyzes the process of intergenerational language shift from a sociolinguistic perspective and proposes a pedagogical model for expanding the stylistic range of heritage learners, targeting the development of writing proficiency. The model proposes that the curriculum should be organized so that students initially draw on their knowledge of the spoken language. The norms of various written genres are introduced gradually, progressing from less to more formal and more complex discourse types, with an emphasis on text cohesion.
Casarão Amália Noll: An architectural mosaic of the immigration in southern Brazil
Authors: Uez Pablo Cesar , Rauber Cristiane , Da Silva Juliana Betemps Vaz
Published: February 2021

At the end of the XXI century, a big immigration phenomenon happened in the south of Brazil, when thousands of European decided to leave their native country to look for new and unexplored lands. The material and immaterial multicultural patrimony generated by them remains as history legacy from the European colonization (Portuguese, German and Italian), and many other ethnic groups developed and raised the people of Rio Grande do Sul. In these work we are going to deal particularly with the heritages from the peoples who debarked at Guimarães’ harbor, in São Sebastião do Caí, Rio Grande do Sul, Brazil, that were spread out through communities as the Rio Branco road was opened. This road has an extension of 250 Kilometers moreover, nowadays, it passes through one of the most important industrial developed regions of Brazil. Even so, we can still find through this road many architectonic exemplars of the immigration period, as well as descendants residing on its banks.

The Casarão Amália Noll, in Feliz city, is one of these exemplars of the survival architecture from the past period. This building shows distinct steps and constructive techniques, furthermore we can identify in one single room the presence of the characteristics from the Portuguese, German and Italian architecture. In 2015, the construction finds itself in low state of preservation, when at the time begins the woks of cadastral surveys, diagnosis of pathologies and proposal of intervention.

The present article aim to show the proposed solutions for the first stage of architectonic intervention, in which we opted for the ruin stabilization and for the architectonic volumes restoration. At the new restored space will work a traditional German brewery, called Biergarten of Amália, beyond the museum of craft beer, immaterial heritage brought by the Germany people to the region.
Trabajando la educación ambiental desde la metodología aprendizaje-servicio
Authors: Álvarez-Muñoz José Santiago , Bernárdez-Gómez Abraham , Belmonte María Luisa
Published: February 2021

La educación ambiental queda representada como uno de los ejes transversales que mayor protagonismo ocupa dentro del sistema educativo, cada vez más necesario ante la multitud de amenazas que atentan contra el desarrollo sostenible de nuestro mundo, encontrando en la educación la herramienta perfecta para formar a nuevas generaciones conscientes al respecto. No obstante, a fin de superar métodos de trabajo ya repetitivos y conservadores, se toma en consideración nuevas metodologías emergentes como el aprendizaje servicio, que aúna aprendizaje curricular y moral. Siguiente este marco, se expone un proyecto de aprendizaje servicio basado en el medio ambiente y la sostenibilidad desarrollado en el primer tramo de la Etapa de Educación Primaria. Un modelo de intervención en el que el alumnado es el protagonista y se desarrolla con una finalidad que se materializa, adquiriendo el aprendizaje desde la praxis directa en un contexto real.
Digital Twins by Study and Engineering
Authors: Zacher Serge
Published: February 2021

Generally, a digital twin is a software-model as a prototype for some product, ordered by a customer. It shell be used on all stages of industrial production of this ordered product, compering the actual state with the model und correcting the differences. A “virtual world” will be created from the “real word” and both “worlds” communicate with each other during production. At the educational institutions of engineering like universities, trainings centres or schools the digital twins are software-models of industrial plants, which are simulated and visualized like its industrial originals and synchronized with them. The actual paper, which short edition was presented by Zacher (2020), shows steps of design of digital twins upon some examples of the bachelor’s and master’s degree program at the Universities of Applied Sciences Darmstadt, RheinMain, and the Baden-Wuerttemberg Cooperative University (DHBW) Stuttgart. It will be described why and how it is possible to use the digital twins. The ways from an original device to its model will be drawn. The different stages of the development of software-models, which are equipped with different levels of source code, will be shown. The actual trends to include the hardware into a software-model, so called hardware-in-the-loop and rapid control prototyping, will be described. Finally, the advantages and disadvantages of digital twins for engineering study including the economic considerations will be discussed.
Prevention of ventral hernias using a new technique for accessing the abdominal cavity through the midline of the abdomen with dissection of the navel and umbilical ring: comparison with traditional laparotomy
Authors: Vertyankin S. V. , Vanzha Y. E. , Mayorov R. V. , Yakubenko V. V. , Mayorova M. V. , Kryakvina E. V. , Martirosyan E. A.
Published: February 2021

The problem of postoperative ventral hernias remains relevant due to the high frequency of their development — in 7–24% of patients.Aim.To evaluate the effectiveness of prevention of postoperative ventral hernias using a new technique of access to the abdominal cavity in comparison with traditional laparotomy.Materials and methods.The proposed new technique of access to the abdominal cavity along the midline of the abdomen with dissection of the navel and umbilical ring was carried out in accordance with the method developed by us, registered by the patent of the Russian Federation. For the final analysis, 134 patients were selected, divided into group 1 (n = 67), in which the median access was performed using a new technique, and group 2, in which the traditional median access was performed with the left umbilical ring bypass (n = 67). The initial parameters of patients, characteristics during and after surgery were evaluated. The duration of follow-up after surgery was 24 months.Results.Groups 1 and 2 were comparable by gender, age, body mass index, and the presence of comorbidities. In 79% of patients in group 1 and in 67% of patients in group 2 (the difference is not significant), indications for surgery were malignancies of the abdominal cavity. The groups did not differ in the types of median laparotomy, the time of surgery, the amount of blood loss, the time of removal of postoperative sutures, and the duration of hospitalization. All patients were followed up for 24 months. Postoperative ventral hernia developed in one patient (1.5%) in group 1 and in 5 (7.5%) patients in group 2 within 12 to 24 months after surgery. There were no statistically significant differences in the frequency of hernia development (Mantel — Cox test, p = 0.100)Conclusion.A new method of median laparotomy in the treatment of patients with planned surgical pathology of the abdominal cavity is characterized by a low rate of postoperative hernia development.
VEGF-C — a biomarker of renal injury in the experimental model of intra-abdominal hypertension
Authors: Iakovlev V. V. , Badaeva A. V. , Ivanova E. I. , Severgina L. O. , Maltseva L. D. , Morozova O. L.
Published: February 2021

Lymphangiogenesis plays an important role in development of renal parenchyma inflammation during kidney injury. Vascular endothelial growth factor type C (VEGF-C), cytokine that regulates lymphangiogenesis, is a potential early biomarker for acute kidney injury. Aim. To study the concentration of VEGF-C in renal homogenate and blood serum of newborn rats with experimental intraabdominal hypertension (IAH) of varying severity and duration, to establish a relationship with morphological changes in the renal tissue. Materials and methods. The experiment was conducted on 50 newborn Wistar rats. Rats were divided into 5 groups of 10 rats each: groups 1 and 2 with mild IAH lasting 5 and 10 days, respectively, and groups 3 and 4 with severe IAH lasting 5 and 10 days, respectively, and the control group. IAH was modelled by injecting sterile vaseline into the abdominal cavity to a predetermined level of IAH under the control of intra-vesical manometry. VEGF-C content was measured by ELISA. Morphological examination of the biopsy material and its photography were carried out using a Leica DM2000 microscope. The Mann—Whitney, Kruskal—Wallis, Wilcoxon tests, as well as one-way ANOVA, were used for statistical analysis. Results. The level of VEGF-C in the renal homogenate was increased in all groups (pc < 0.001); the degree of VEGF-C increase depended on the severity of IAH (p < 0.05) but not on the duration of IAH exposure. The VEGF-C blood serum level was increased only in group 3 (pc = 0.011). Morphological analysis showed hydropic dystrophy: changes in the height of the tubular epithelium, an increase in interstitial edema, expansion of the urinary spaces of glomeruli. The degree of morphological changes depended on the severity and duration of IAH. Conclusion. Changes in VEGF-C level assessed in the renal homogenate correlated with morphological changes in renal tissue of rats with different severity and duration of IAH.
Role of mesenchymal stromal cells and their secretory products in kidney regeneration
Authors: Payushina O. V. , Tsomartova D. A. , Chereshneva E. V. , Ivanova M. Yu. , Lomanovskaya T. A. , Kuznetsov S. L.
Published: February 2021

Kidney diseases are an important medical problem. Kidney injuries are accompanied by oxidative stress, cell death, capillary destruction, inflammation and fibrosis. Mesenchymal stromal cells (MSCs) have a complex effect on the regeneration by producing various regulatory molecules, including those inside extracellular vesicles, and therefore are considered as a promising therapeutic resource for cell therapy of kidney diseases. Their renoprotective effect has been shown in different experimental models, but the results of the clinical trials are ambiguous. Clinical use of MSCs is complicated by their low survival rate in the injured kidney, potential immunogenicity, tumorogenicity and fibrogenicity. Cell-free therapy with the secretory products of MSCs such as conditioned environments or extracellular vesicles is a promising direction for using their regenerative potential. However, introduction of MSCs and their secretory products into medical practice requires further research into the mechanisms of their proregenerative action, improvement of cultivation protocols, and more clinical trials.
Features of the manifestation and course of Crohn’s disease in three brothers
Authors: Morkovina A. V. , Yuryeva E. Yu. , Lapina T. L. , Pavlov P. V. , Tertychnyy A. S. , Sheptulin A. A.
Published: February 2021

Hereditary predisposition is the most significant risk factor for Crohn’s disease (CD) in siblings. Case reports. CD was diagnosed in 3 brothers in a family with 6 children of the same generation: the disease manifested itself in one — at the age of 15 years and in two brothers — at the age of 17 years. In the older brother, CD manifested with acute intestinal obstruction, ileum perforation, diffuse peritonitis; in the middle — with symptoms similar to appendicular infiltrate. Both brothers underwent resection of the terminal ileum, cecum, and part of the ascending colon with the imposition of ileoascendoanastomosis. The younger brother was diagnosed with a non-stricturing, non-penetrating form of CD with a gradual onset and no complications. Among the siblings without CD, two have rheumatoid arthritis and vitiligo. Discussion. Similar signs of the familial form of CD were young age of manifestation and ileocolonic disease location; distinctive signs — the presence of complications and surgical interventions in only two brothers. A special feature of the case reports is the CD development only in boys and the combination of three different autoimmune diseases in one generation of the family.
ECOLOGICAL THINKING DEVELOPMENT OF STUDENTS
Authors: Abdullayeva Sh
Published: February 2021

The thesis examines the concept of ecological thinking, factors and methods of its formation and development.
THE ANALYSIS OF LAW ON PROTECTION AND RATIONAL USE OF FAUNA
Authors: Narzullaev Olim
Published: February 2021

This article reveals the issues of legal regulatin of the protectionand use of the animal world, as one of the types of biological resources defined inthe legislation of wild animals living in a state of natural freedom in water,atmosphere and soil, permanently or temporarily in the territory of the Republic ofUzbekistan, as well as animal world bred in semi-free living conditions or artificiallycreated for scientific or environmental purposes established by legislation on theprotection and use of wildlife, in addition, taking into account the narrowness andcontent of international legal acts “On Wetlands of International Importance, Mainlyas Habitats of Waterfowl”, “On International Trade in Endangered Species of WildFauna and Flora”, “On the Conservation of Migratory Species of Wild Animals”,“On Biological Diversity” based on the essence of the content of internationalinstruments, it is analyzed on the basis of the national legislation of Uzbekistan.
Nation Building and Social Values in Nepal
Authors: Ghimire Tara Nath , Shrestha Amrit Kumar , Phuyel Shyam Prasad
Published: February 2021

Social norms play an important role in the state-building process. If the time of formation of Nepal is considered as the period of unification, then some important facts regarding the formation of the state of Nepal and the structure of the society here can be recounted. Regarding the formation of the nation-state, the structure of the Nepali state, and the position of the Nepali society are not of the same nature. From the pre-unification states of Limbuwan, Khumbuwan, Kirat, Khas, Baisi, Chaubisi, Shen, etc. to the restructuring period of the state, the state structure has not been formed in the recognition of the nation-state. Because the small and big states before unification were states built on power. Due to power, the great form of the Gurkha state had built a unitary Nepal. There is not general recognition of the state-building process of the nation-state. In the same way, even when restructuring the state, that recognition was not accepted. The foundations of federal-state formation, such as language, religion, and the basis of equality and plurality of the population, were also not accepted, which is a form of recognition of the nation-state. In such a situation, this article attempts to study a state-building and social tradition which is already coming together in Nepali society
Legal Strengthening of Credit Agreement Based on Information Technology in Financial Technology Companies in Supporting Industry 4.0
Authors: Ramlan Ramlan
Published: February 2021

Changes in the pattern of lending and borrowing also experienced growth over the development period. From a system that manually switches to digital. Since the existence of general information, technology-based credit services have been quite good in supporting industry 4.0, but there are still problems such as high-interest rates, and there are several debtor rights violated that need to be discussed regarding legal arrangements and legal strengthening. The research method is the type of normative legal research, how to collect data from library research and analysis of data with qualitative analysis. The results showed that financial technology regulation is regulated in the OJK Law, ITE Law, POJK, and PBI, and concerning legal reinforcement is needed for the problem of high-interest rates to debtors, electronic agreement standard clauses, threats, defamation, and violating customer privacy so that they can attract more many investors in supporting industry 4.0 with the use of financial technology, because the problem is only still regulated in the ITE Law has not been specifically applied in the implementation of financial technology.
The Effect of Using Wikis on the Students’ Reading Comprehension in Learning English
Authors: Bakhtiarvand Morteza
Published: February 2021

The aim of this study was to evaluate the impact of the use of wikis on the ability to understand semantic meaning of English. At the beginning of the study, a reading comprehension proficiency test was administered for two groups of students in order to determine the level of reading comprehension skills. Then the pre-test were given to the students of both control and experimental groups. After the pre-test, students in both groups for 6 weeks and every week for two hours were trained for learning English reading comprehension proficiency skills. The difference is that students in the control group were trained in traditional way and the students in experimental group were trained by using wikis. At the end of four weeks, the post test was administered for students in both groups. Four standard tools were used for data collection in this study. At first reading comprehension proficiency test was given to two groups in order to determine the level of reading comprehension skills. The second tool was a test that was used as pre-test, post-test and delayed post-test. The third instrument was reading comprehension texts that were selected from different sites of Wiki (e.g., Wikipedia, Wiki Facebook, wiki, wiki Dick, Wiki News) in both form of offline and online will be available to students. The fourth instrument was Systematic Functional Grammar (SFG) scale for difficulty level of texts (Shokrpour, 2004). The descriptive statistics indicators such as frequency, mean and standard deviation of scores and in the inferential part in order to examining the hypothesis, one-way analysis of covariance (ANCOVA) was used. The results showed that the use of wikis increase the ability to understand the semantic meaning of words
The Offspring Absence Factor Divorce Runs in the Family (Case Study at the Religious Court Medan in 2020)
Authors: Rizal M , Djannah Fathul
Published: February 2021

Divorce is the end of a marriage. Divorce is a break in the relationship between husband and wife. Every married couple must have their ways to prevent a divorce from happening. Divorce is always based on quarrels between husband and wife. This is the reason that a dispute between husband and wife occurs because one of the parties wants a divorce, therefore the family relationship is not harmonious. Offspring who are not present in the household is very important, apart from being the successor of the heir, children are also the goal of a harmonious household, especially if certain tribes or customs require an offspring to be the successor of the family name. In this case, the applicant and the defendant both did not want to adopt a child, so they decided to divorce at Religious Court Medan
A Associação Rural de Bagé (1939): patrimônio da arquitetura moderna bajeense
Authors: Gonçalves Magali
Published: February 2021

O trabalho refere-se a um estudo analítico dos Pórtico de Acesso, Sede Social e Tribunas da Associação Rural de Bagé-RS, implantados no Parque Visconde Ribeiro de Magalhães, projeto do engenheiro porto-alegrense Carlos Machado Moreira, com base na dissertação de mestrado da autora “Arquitetura Bajeense - o delinear da modernidade: 1930-1970”. Moreira, desenvolvendo sua obra em uma gama diversa de estéticas, o que era comum à época - década de 1940, projeta os exemplares como manifestações do estilo protomoderno, com elementos do art déco, estratégias compositivas que transferem às mesmas um caráter apropriado. Os prédios, condicionados à preservação plena dos seus elementos construídos - interna e externamente, alinham- se temporalmente às estéticas praticadas no Rio Grande do Sul e estão incluídos no conjunto de exemplares inventariados pelos Instituto do Patrimônio Histórico e Artístico Nacional – IPHAN e pelo Instituto do Patrimônio Histórico e Artístico do Estado – IPHAE como patrimônio histórico, cultural e arquitetônico bajeense.
Faculdade de Ciências Econômicas: origem do ensino superior em Bagé
Authors: Silveira Marilene , Ismério Clarisse , Dias Elis
Published: February 2021

A criação da Faculdade de Ciências Econômicas inicia o ensino superior em Bagé. E diante de sua importância histórica, objetivamos narrar como ocorreu esse processo. Para tanto, primeiramente apresentamos um breve relato da história econômica de Bagé. E, posteriormente, mostramos, a partir de fontes documentais institucionais, como ocorreu a implantação da Faculdade de Ciências Econômicas e seus desdobramentos. Assim, podemos concluir, a partir das evidências, que as origens do ensino superior em Bagé estão ligadas à necessidade de achar alternativas para o desenvolvimento da região. Investir na formação da juventude era vislumbrar um futuro próspero para o município.
Valorização Patrimonial: através do cinema como meio
Authors: Menezes Vinicius
Published: February 2021

No presente trabalho, foram analisadas as possibilidades de desenvolvimento sustentável através da valorização do patrimônio cultural fazendo uso do cinema. Temos como objetivos compreender como a população da região se apropria dessas imagens cinematográficas e identifica-se com as identidades na tela grande. Através de pesquisa metodológica, analítica qualitativa e revisão bibliográfica, fizemos uma análise de obras acerca do cinema e do turismo, cruzando tais informações para poder direcioná-las para uma forma de desenvolvimento sustentável. Conseguimos perceber que não há um conceito definitivo de desenvolvimento e nem uma fórmula exata, mas existem diversas formas de conseguir atingir o objetivo desenvolvimentista.
A magyar kiegészítő nyugdíjpillér elemei és értékelése az EU elvárásainak szemszögéből
Authors: Barta Judit
Published: February 2021

The structure, the current role, and the individual elements of the Hungarian supplementary pension scheme are presented in this study. As a Member State, it is important to follow the running courses related to the pension scheme and the supplementary pension scheme in the European Union (EU) as well as the problems declared and the answers given in the EU, which are also outlined in this paper.
Vitából innováció – Modern konfliktusrendezési törekvések a kreativitás előmozdításáért
Authors: Hrecska-Kovács Renáta
Published: February 2021

"A properly trained and experienced HR professional not only understands what kind of employees an employer needs but is also able to smooth out disagreements that can lead to the loss of valuable human labour or the weakening of the employer’s economic position. The research examines the out-of-court settlement of conflicts in the field of employment in the strict sense, which can make labour conflict resolution not only more rapid but also cheaper than litigation and more effective than termination of employment. Last but not least, it also opens up space for innovation.
The literature on innovation is extensive, with many also researching how a company can grow through innovative solutions arising from exchange of views between employer and employee. However, little research is done on how workplace conflicts and their solutions can steer parties towards innovative corporate leadership. In resolving conflicts, new ideas, concepts, and strategies can emerge in both the employee and the employer that can become the key to shared development, and thus mediation as a hidden resource can participate in corporate operations."
A fogvatartottak munkáltatásának egyes kérdéseiről
Authors: Szabó András
Published: February 2021

"The history of the development of the employment of prisoners has come a very long way, from hard labour to resocialization. Today the rights of prisoners are respected in their work, but these rights are sometimes different from the normal labour rights.
In this study, I review the most relevant difference between the prisoners’ labour rights and the ordinary labour rights. Beyond that, I examine if the intentions formulated in 2015 − full employment and self-sustaining prisons in Hungary − have been achieved or not. In my study, I present some criminal statistics of the employment rates in Hungarian prisons."