bluuebunny/crossref_metadata_2025 huggingface dataset:
Fair Enough?
Authors: Cavaillé Charlotte
Published: September 2023

Fair Enough? proposes and tests a new framework for studying attitudes toward redistributive social policies. These attitudes, the book argues, are shaped by at least two motives. First, people support policies that increase their own expected income. Second, they support policies that move the status quo closer to what is prescribed by shared norms of fairness. In most circumstances, saying the “fair thing” is easier than reasoning according to one's pocketbook. But there are important exceptions: when policies have large and certain pocketbook consequences, people take the self-interested position instead of the 'fair' one. Fair Enough? builds on this simple framework to explain puzzling attitudinal trends in post-industrial democracies including a decline in support for redistribution in Great Britain, the erosion of social solidarity in France, and a declining correlation between income and support for redistribution in the United States.
Graph Spectra for Complex Networks
Authors: Van Mieghem Piet
Published: September 2023

This concise and self-contained introduction builds up the spectral theory of graphs from scratch, with linear algebra and the theory of polynomials developed in the later parts. The book focuses on properties and bounds for the eigenvalues of the adjacency, Laplacian and effective resistance matrices of a graph. The goal of the book is to collect spectral properties that may help to understand the behavior or main characteristics of real-world networks. The chapter on spectra of complex networks illustrates how the theory may be applied to deduce insights into real-world networks. The second edition contains new chapters on topics in linear algebra and on the effective resistance matrix, and treats the pseudoinverse of the Laplacian. The latter two matrices and the Laplacian describe linear processes, such as the flow of current, on a graph. The concepts of spectral sparsification and graph neural networks are included.
Warfare in the Latin East, 1192–1291
Authors: Marshall Christopher
Published: September 2023

This book offers a detailed examination of warfare in the Latin East from the end of the Third Crusade, to the demise of the Latin Kingdom in 1291. It considers both the crusades and the long periods of truce during which warfare was restricted to raiding expeditions and conflict among the Christians themselves. A study of the organisation of the Latin armies is followed by an examination of the structures and functions of the strongpoints, with differentiation between armed conflict, battles, raids and sieges. Marshall depicts raiding expeditions as a vital factor in the Muslims' efforts to remove Latins from the East, and concludes with a brief study of the work of scouts, spies and traitors in the Muslim and Latin armies.
Application of OpenAI GPT-4 for the retrospective detection of catheter-associated urinary tract infections in a fictitious and curated patient data set
Authors: Perret Jasmin , Schmid Adrian
Published: September 2023

The use of the OpenAI GPT-4 model in detecting catheter-associated urinary tract infection (CAUTI) cases in small fictitious and curated patient data sets was investigated. Final analysis of 50 patients including 11 CAUTI cases yielded sensitivity, specificity and positive and negative predictive values of 91%, 92%, 83%, and 96%, respectively.
National validation of the Centers for Medicare & Medicaid Services strategy for identifying potential surgical-site infections following colon surgery and abdominal hysterectomy
Authors: Calderwood Michael S. , Kleinman Ken , Bruce Christina B. , Shimelman Lauren , Kaganov Rebecca E. , Platt Richard , Huang Susan S.
Published: September 2023

Objective:

National validation of claims-based surveillance for surgical-site infections (SSIs) following colon surgery and abdominal hysterectomy.

Design:

Retrospective cohort study.

Setting:

US hospitals selected for data validation by Centers for Medicare & Medicaid Services (CMS).

Participants:

The study included 550 hospitals performing colon surgery and 458 hospitals performing abdominal hysterectomy in federal fiscal year 2013.

Methods:

We requested 1,200 medical records from hospitals selected for validation as part of the CMS Hospital Inpatient Quality Reporting program. For colon surgery, we sampled 60% with a billing code suggestive of SSI during their index admission and/or readmission within 30 days and 40% who were readmitted without one of these codes. For abdominal hysterectomy, we included all patients with an SSI code during their index admission, all patients readmitted within 30 days, and a sample of those with a prolonged surgical admission (length of stay > 7 days). We calculated sensitivity and positive predictive value for the different groups.

Results:

We identified 142 colon-surgery SSIs (46 superficial SSIs and 96 deep and organ-space SSIs) and 127 abdominal-hysterectomy SSIs (58 superficial SSIs and 69 deep and organ-space SSIs). Extrapolating to the full CMS data validation cohort, we estimated an SSI rate of 8.3% for colon surgery and 3.0% for abdominal hysterectomy. Our colon-surgery surveillance codes identified 93% of SSIs, with 1 SSI identified for every 2.6 patients reviewed. Our abdominal-hysterectomy surveillance codes identified 73% of SSIs, with 1 SSI identified for every 1.6 patients reviewed.

Conclusions:

Using claims to target record review for SSI validation performed well in a national sample.
The Attorney General and contempt of court – some political and constitutional concerns
Authors: McGarry John
Published: September 2023

The Attorney General for England and Wales is the Government's Senior Law Officer who, inter alia, initiates certain kinds of legal proceedings. She is also a politician: a member of the House of Commons or the House of Lords and appointed to Government by the Prime Minister. This paper considers the Attorney General's role in initiating contempt proceedings against fellow politicians. I detail a number of cases where politicians have been involved in potential contempts by publication. I argue that, in such cases, the Attorney General's position may amount to an actual or perceived conflict of interest and may breach the principle that justice should be seen to be done.
Feeding habits of the sharpnose shark Rhizoprionodon longurio on the west coast of the Gulf of California, Mexico
Authors: Hernández-Aparicio Amairani , Galván-Magaña Felipe , Simental-Anguiano María Del Rosario
Published: September 2023

The sharpnose shark (Rhizoprionodon longurio) is among the top three shark species captured by artisanal fisheries of the Gulf of California. This study includes information regarding the feeding habits of this species using the stomach contents of 70 individuals ranged from 54 to 109 cm in total length (TL). Out of the 16 prey items identified, fish of the families Scombridae (Scomber japonicus; prey-specific relative importance index [%PSIRI] = 6.3) and Batrachoididae (%PSIRI = 5.5), the cephalopod Lolliguncula spp. (%PSIRI = 6.3), and the crustacean Pleuroncodes planipes (%PSIRI = 4.3) were the most important prey. Only female stomachs were obtained (N = 19) in the central area of the gulf, and the PSIRI indicated that the preferred prey were the cephalopod Lolliguncula spp. (%PSIRI = 10.5) and fish of the Sparidae family (Calamus brachysomus; %PSIRI = 5.8). The number of stomachs was not sufficient to analyse differences by sex. Regarding its trophic position, R. longurio was a tertiary consumer (TL
K
= 4.4). A TL
K
= 4.4 was calculated for the central area, and a TL
K
= 4.3 for the southern area. According to Levin's index (Bi), this shark is a specialist predator in the whole study area (Bi = 0.19), including the centre (Bi = 0.29). Conversely, it was considered a generalist predator in the southern area (Bi = 0.63). The high quantity of empty stomachs could relate to the time the sharks were caught in fishing a gear.
Tunis in the Global Radical Web: Diasporas, Transnational Anarchism, and Labor Movements (1887–1912)
Authors: Montalbano Gabriele
Published: September 2023

The paper focuses on the Italian-speaking anarchists of the end of the nineteenth century and their involvement and legacy in trade union movements and strikes in Tunis during the first decade of the twentieth century. A perspective privileging the internationalist and trade-unionist activities, and their impact on that specific colonial context, avoids the dangers of a rigid ethnoscape and methodological nationalism. Even though most of the actors of this story were considered by the states as Italian nationals, their conflictual (at least for the anarchists) nationality helps us to understand the complexity of the national-cultural belonging of subversive migrants in the Imperial Mediterranean. The ideological struggle on the subversive legacy of Giuseppe Garibaldi at the end of the nineteenth century and the conflictual relations of the trade unions with consular authorities at the beginning of the twentieth century showed an Italian-speaking internationalism in the Southern Mediterranean shore, tightly connected with the European and the American areas. Based on understudied diplomatic, colonial, and police records, this research aims at analyzing the attempts of an international working-class movement in a hierarchical colonial situation also through Italian, French, and Tunisian sources.
Diversity protects: The role of school and classroom racial/ethnic diversity on the experience of peer victimization during the middle school years
Authors: Graham Sandra , Echols Leslie
Published: September 2023

The effects of school and classroom racial/ethnic diversity on peer victimization, self-blame, and perceived school safety were examined in a racially/ethnically diverse sample of students followed over the three years of middle school. Sixth grade students (N = 5,991, 52% female; M = 11.63 years) were recruited from 26 urban middle schools that systematically varied in racial/ethnic diversity. Based on student self-report, the sample was 31.6% Latino/Mexican, 19.6% White, 17.4%, Multiethnic/Biracial, 13% East/Southeast Asian, 10.9% Black, and 6.9% Other very small racial/ethnic groups. Each school had a structural diversity score based on the number and size of racial/ethnic groups enrolled. Using a novel method based on course schedules and class rosters, each student’s individual exposure to diversity in their classes was assessed to capture dynamic diversity. Latent growth modeling showed that structural school diversity and dynamic classroom diversity were both related to less victimization at the start of middle school and a decrease over time. Dynamic classroom diversity buffered the associations between victimization and self-blame and between victimization and perceiving school as unsafe. Dynamic classroom diversity was more protective than structural school diversity. Implications for practice, intervention and policies to promote school racial/ethnic diversity were discussed.
Southeast Asia and the Mediterranean World at the Turn of the First Millenniumce: Networks, Commodities and Cultural Reception
Authors: Hoppál Krisztina , Bellina Bérénice , Dussubieux Laure
Published: September 2023

Archaeological materials from the Mediterranean world in Southeast Asia are scarce and their social context and cultural implications are rarely considered, while objects in Mediterranean style are often misinterpreted or overlooked. Concomitant to the increasing implementation of laboratory analysis, the range of new evidence, especially coming from recently excavated sites in Thailand and Myanmar, along with the reinterpretation of earlier data now brings the potential to compare different regions, and to discuss possible variations in terms both of the diversity and density of Roman materials. This study includes Mediterranean imports produced between the last centuriesbceand first centuriesce, as well as Asia-produced inspired objects that integrate Mediterranean elements to varying degrees, combining new data and re-analysed materials. The paper not only contributes to building the sequence of cultural exchanges, but also interprets in cultural terms the varying Mediterranean elements present.
Sudden-Onset Disaster Mass-Casualty Incident Response: A Modified Delphi Study on Triage, Prehospital Life Support, and Processes
Authors: Cuthbertson Joe , Weinstein Eric , Franc Jeffrey Michael , Jones Peter , Lamine Hamdi , Magalini Sabina , Gui Daniele , Lennquist Kristina , Marzi Federica , Borrello Alessandro , Fransvea Pietro , Fidanzio Andrea , Benítez Carlos Yanez , Achaz Gerhard , Dobson Bob , Malik Nabeela , Neeki Michael , Pirrallo Ronald , Castro Delgado Rafael , Strapazzon Giacomo , Farah Dell’Aringa Marcelo , Brugger Hermann , Rafalowsky Chaim , Marzoli Marcello , Fresu Giovanni , Kolstadbraaten Knut Magne , Lennquist Stenn , Tilsed Jonathan , Claudius Ilene , Cheeranont Piyapan , Callcut Rachel , Bala Miklosh , Kerbage Anthony , Vale Luis , Hecker Norman Philipp , Faccincani Roberto , Ragazzoni Luca , Caviglia Marta
Published: September 2023

The application and provision of prehospital care in disasters and mass-casualty incident response in Europe is currently being explored for opportunities to improve practice. The objective of this translational science study was to align common principles of approach and action and to identify how technology can assist and enhance response. To achieve this objective, the application of a modified Delphi methodology study based on statements derived from key findings of a scoping review was undertaken. This resulted in 18 triage, eight life support and damage control interventions, and 23 process consensus statements. These findings will be utilized in the development of evidence-based prehospital mass-casualty incident response tools and guidelines.
Introduction: What Scholars Know (and Need to Know) about the Politics of Climate Change
Authors: Hadden Jennifer , Prakash Aseem
Published: September 2023

Climate change is fundamentally a political problem; it is not merely a technical or economic challenge but rather an arena for sharp conflicts over the distribution of gains and losses and the associated ethical challenges. However, as Keohane (2015), Javeline (2014), and Green and Hale (2017) noted in PS: Political Science & Politics and Perspectives on Politics, research on climate change has not been traditionally central to mainstream political science. Field journals including Global Environmental Politics and Environmental Politics have made important contributions in this regard, and leading university presses have published important books on climate issues. However, the neglect of climate politics by mainstream journals is surprising—although we note the recent Perspective on Politics symposium on Green Political Science—because political scientists have devoted considerable attention to studying environmental politics at the community (Ostrom 1990), national (Kelemen and Vogel 2010), and international (Young 1994) levels. Indeed, there is robust literature on the management of common pool resources, national styles of environmental regulation, and environmental social movements, as well as global environmental regimes. Yet, the topic of climate change—an important subject in the study of environmental politics—too often has been neglected by mainstream political science.
Elinor Ostrom on choice, collective action and rationality: a Senian analysis
Authors: Lewis Paul , Petersen Matias
Published: September 2023

This paper explores Elinor Ostrom's account of practical reason through the conceptual lens provided by a typology of dimensions of rational conduct advanced by Amartya Sen. On Sen's view, self-interested behaviour has three independent, and separable, features: self-centred welfare, self-welfare goal and self-goal choice. We suggest that Ostrom is committed to a version of rational choice theory that retains the assumptions of self-welfare goal and self-goal choice but, by acknowledging that people's welfare is affected by factors beyond their material consumption, departs from the assumption of self-welfare goal. We argue that this departure is not necessarily driven by an acknowledgement, along Senian lines, that people may have reasons for action other than the single-minded pursuit of their own goals, but rather by Ostrom's belief that the decision problem people face is so complex that maximising behaviour is rendered impossible. We illustrate this argument by analysing how Elinor Ostrom's position differs not only from Sen's but also from that of her husband and long-time collaborator Vincent Ostrom, who in his analysis of the covenantal aspects of rule-making seems to depart from the assumptions of instrumental rationality and preference-satisfaction.
Exploring the supervisory relationship in the context of culturally responsive supervision: a supervisee’s perspective
Authors: Vekaria Bianca , Thomas Tessa , Phiri Peter , Ononaiye Margarita
Published: September 2023

Clinical supervision is a relationship-based education, considered crucial in providing clinicians with emotional support, skill development and improving client outcomes. Culturally responsive supervision assumes that culture permeates clinical practice and supervision. Culturally responsive supervisors promote the development of cultural competence in supervision, through modelling, reflective discussion and responsivity. Research has demonstrated that greater perceived cultural responsivity in supervision may result in greater satisfaction for supervisees, particularly those from racially or ethnically minoritised (REM) backgrounds. The current study explores supervisee perceptions of culturally responsive supervision and supervisory relationships between different supervisory dyads, comprising supervisees from REM and White backgrounds. This was a cross-sectional design incorporating a between-groups comparison. Trainee and qualified clinical psychologists, counselling psychologists and CBT therapists (n = 222) completed an online survey. Perceptions of cultural responsivity and the supervisory relationship were explored. Participants provided information about their supervisor’s race and ethnicity and their own, and were organised into four supervisory dyads. Participants from REM backgrounds in dyads with White supervisors perceived their supervision as significantly less culturally responsive, with significantly lower quality supervisory relationships. Greater perceived cultural responsivity in supervision significantly predicted better supervisory relationships (regardless of participant cultural background). Findings suggest that culturally responsive supervisory practices may play an important role in developing cultural competence and strengthening the supervisory relationship, particularly in cross-cultural supervisory dyads. Findings present important clinical and theoretical implications.

Key learning aims

(1)

To understand the need for cultural responsivity within the context of clinical supervision.

(2)

To explore the differences between cross-cultural and culturally similar supervisory dyads in perceptions of cultural responsivity in supervision.

(3)

To explore the differences between cross-cultural and culturally similar supervisory dyads in perceptions of the quality of the supervisory relationship.

(4)

How does culturally unresponsive supervision impact supervisee experiences?
Resolving the Carbon‐Climate Feedback Potential of Wetland CO2 and CH4 Fluxes in Alaska
Authors: Ma Shuang , Bloom A. Anthony , Watts Jennifer D. , Quetin Gregory R. , Donatella Zona , Euskirchen Eugénie S. , Norton Alexander J. , Yin Yi , Levine Paul A. , Braghiere Renato K. , Parazoo Nicholas C. , Worden John R. , Schimel David S. , Miller Charles E.
Published: September 2023

Boreal‐Arctic regions are key stores of organic carbon (C) and play a major role in the greenhouse gas balance of high‐latitude ecosystems. The carbon‐climate (C‐climate) feedback potential of northern high‐latitude ecosystems remains poorly understood due to uncertainty in temperature and precipitation controls on carbon dioxide (CO2) uptake and the decomposition of soil C into CO2 and methane (CH4) fluxes. While CH4 fluxes account for a smaller component of the C balance, the climatic impact of CH4 outweighs CO2 (28–34 times larger global warming potential on a 100‐year scale), highlighting the need to jointly resolve the climatic sensitivities of both CO2 and CH4. Here, we jointly constrain a terrestrial biosphere model with in situ CO2 and CH4 flux observations at seven eddy covariance sites using a data‐model integration approach to resolve the integrated environmental controls on land‐atmosphere CO2 and CH4 exchanges in Alaska. Based on the combined CO2 and CH4 flux responses to climate variables, we find that 1970‐present climate trends will induce positive C‐climate feedback at all tundra sites, and negative C‐climate feedback at the boreal and shrub fen sites. The positive C‐climate feedback at the tundra sites is predominantly driven by increased CH4 emissions while the negative C‐climate feedback at the boreal site is predominantly driven by increased CO2 uptake (80% from decreased heterotrophic respiration, and 20% from increased photosynthesis). Our study demonstrates the need for joint observational constraints on CO2 and CH4 biogeochemical processes—and their associated climatic sensitivities—for resolving the sign and magnitude of high‐latitude ecosystem C‐climate feedback in the coming decades.
The Effect of Arctic Sea‐Ice Loss on Extratropical Cyclones
Authors: Hay Stephanie , Priestley Matthew D. K. , Yu Hao , Catto Jennifer L. , Screen James A.
Published: September 2023

Taking advantage of the Polar Amplification Model Intercomparison Project simulations and using a Lagrangian objective feature tracking algorithm, we determine the response of extratropical cyclones to sea‐ice loss and consequent weakening of the equator‐to‐pole near‐surface temperature gradient. The wintertime storm tracks are found to shift equatorward in the North Atlantic and over Europe, and eastward in the North Pacific. In both regions, cyclones become weaker and slower, particularly on the poleward flank of the storm tracks. On average, there are fewer individual cyclones in the extratropics each winter, they last longer, are weaker, and travel more slowly. These changes are greatest over the Arctic, but still statistically significant in midlatitudes despite being small compared to internal variability. Inter‐model spread in cyclone responses are not strongly correlated with that in Arctic warming or Arctic amplification. Little change in summertime cyclones is found.
Closing in on Hydrologic Predictive Accuracy: Combining the Strengths of High‐Fidelity and Physics‐Agnostic Models
Authors: Tran Vinh Ngoc , Ivanov Valeriy Y. , Xu Donghui , Kim Jongho
Published: September 2023

Applications of process‐based models (PBM) for predictions are confounded by multiple uncertainties and computational burdens, resulting in appreciable errors. A novel modeling framework combining a high‐fidelity PBM with surrogate and machine learning (ML) models is developed to tackle these challenges and applied for streamflow prediction. A surrogate model permits high computational efficiency of a PBM solution at a minimum loss of its accuracy. A novel probabilistic ML model partitions the PBM‐surrogate prediction errors into reducible and irreducible types, quantifying their distributions that arise due to both explicitly perceived uncertainties (such as parametric) or those that are entirely hidden to the modeler (not included or unexpected). Using this approach, we demonstrate a substantial improvement of streamflow predictive accuracy for a case study urbanized watershed. Such a framework provides an efficient solution combining the strengths of high‐fidelity and physics‐agnostic models for a wide range of prediction problems in geosciences.
The Role of Nonlinear Energy Advection in Forming Asymmetric Structure of ENSO Teleconnections Over the North Pacific and North America
Authors: Wang Ya , Hu Kaiming , Huang Gang , Tao Weichen
Published: September 2023

In boreal winter, the El Niño/Southern Oscillation (ENSO)‐induced Pacific‐North American (PNA) teleconnection pattern is farther westward during La Niña relative to that in El Niño, causing discernible distinct climate implications. However, there has been a lack of consensus regarding the underlying mechanism driving this asymmetric structure. This study highlights the contribution of nonlinear kinetic energy advection (nKA) to this asymmetry. The zonally symmetric responses to ENSO, specifically the anomalies in zonal mean zonal flow, generate opposing nKA patterns by advecting anomalous eddy kinetic energy in the North Pacific, which leads to the shift of the PNA teleconnection pattern. In addition to nKA, transient eddy activities responded to changes of baroclinicity help maintain the asymmetry through a feedback effect. These findings underscore the importance of considering extratropical factors, such as nonlinear energy processes and synoptic‐scale transient eddies, in understanding the mechanism responsible for the asymmetric structure of the PNA teleconnection pattern.
Global Analysis of Height‐Resolved Ice Particle Categories From Spaceborne Lidar
Authors: Sato Kaori , Okamoto Hajime
Published: September 2023

A more accurate representation of ice‐phase processes in numerical models necessitates an enhanced understanding of ice‐particle microphysics and their respective formation conditions. Prior in situ measurements have noted distinctive ice‐particle shape characteristics associated with different cloud systems and geographical locations. The recent advancement in ice‐particle backscattering theories enables a more comprehensive exploration of the geographical distribution and seasonal dependence of ice‐particle shape categories than ever before. This exploration is being undertaken for the first time using space‐borne lidar measurements. Distinct geographical preferences were observed for five different ice‐particle categories. Bullets/rosettes were the most common, followed by Voronois, which were especially prevalent in high‐level tropical clouds, and 2D columns, which were commonly found in mid‐ and low‐level clouds. Droxtals were primarily observed in high‐level subtropical regions. The global distribution of ice‐particle types provides valuable insights into the physical processes related to ice cloud particle shape formation, cloud duration, and radiative impacts.
PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia
Authors: Shah Kinjal , Nasimian Ahmad , Ahmed Mehreen , Al Ashiri Lina , Denison Linn , Sime Wondossen , Bendak Katerina , Kolosenko Iryna , Siino Valentina , Levander Fredrik , Palm-Apergi Caroline , Massoumi Ramin , Lock Richard B. , Kazi Julhash U.
Published: September 2023

The deregulation of BCL2 family proteins plays a crucial role in leukemia development. Therefore, pharmacological inhibition of this family of proteins is becoming a prevalent treatment method. However, due to the emergence of primary and acquired resistance, efficacy is compromised in clinical or preclinical settings. We developed a drug sensitivity prediction model utilizing a deep tabular learning algorithm for the assessment of venetoclax sensitivity in T-cell acute lymphoblastic leukemia (T-ALL) patient samples. Through analysis of predicted venetoclax-sensitive and resistant samples, PLK1 was identified as a cooperating partner for the BCL2-mediated antiapoptotic program. This finding was substantiated by additional data obtained through phosphoproteomics and high-throughput kinase screening. Concurrent treatment using venetoclax with PLK1-specific inhibitors and PLK1 knockdown demonstrated a greater therapeutic effect on T-ALL cell lines, patient-derived xenografts, and engrafted mice compared with using each treatment separately. Mechanistically, the attenuation of PLK1 enhanced BCL2 inhibitor sensitivity through upregulation of BCL2L13 and PMAIP1 expression. Collectively, these findings underscore the dependency of T-ALL on PLK1 and postulate a plausible regulatory mechanism.
Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors
Authors: Chen Yu , Yamamoto Tatsuki , Takahashi Yura , Moro Tomoka , Tajima Tomoko , Sakaguchi Yukiko , Sakata Naoaki , Yokoyama Akihiko , Hijioka Susumu , Sada Akane , Tabata Yuko , Ohki Rieko
Published: September 2023

Insulin signaling often plays a role in the regulation of cancer, including tumor initiation, progression, and response to treatment. In addition, the insulin-regulated PI3K-Akt-mTOR pathway plays an important role in the regulation of islet cell proliferation, and this pathway is hyperactivated in human non-functional pancreatic neuroendocrine tumors (PanNETs). We, therefore, investigated the effect of a very low carbohydrate diet (ketogenic diet) on a mouse model that develops non-functional PanNETs to ask how reduced PI3K-Akt-mTOR signaling might affect the development and progression of non-functional PanNET. We found that this dietary intervention resulted in lower PI3K-Akt-mTOR signaling in islet cells and a significant reduction in PanNET formation and progression. We also found that this treatment had a significant effect on the suppression of pituitary NET development. Furthermore, we found that non-functional PanNET patients with lower blood glucose levels tend to have a better prognosis than patients with higher blood glucose levels. This preclinical study shows that a dietary intervention that results in lower serum insulin levels leads to lower insulin signals within the neuroendocrine cells and has a striking suppressive effect on the development and progression of both pancreatic and pituitary NETs.
Safety outcomes of the first Rigi10™ malleable penile prostheses implanted worldwide
Authors: Wilson Steven K. , Wen Lexiaochuan , Carrion Rafael , Eid Francois , Lentz Aaron , Shah Bhavik , Koca Orhan , Hammad Muhammed A. M. , Gupta Vijayant Govinda , Hamdan Mohammad
Published: September 2023

Implantation of penile prosthesis is considered when conservative measures fail or are unacceptable to patients’ wishing treatment for erectile dysfunction. In the United States (US), inflatable penile prostheses are more often used than malleable penile prostheses (MPP). Outside the US, the reverse is true because third-party reimbursement is not available, and MPP is considerably cheaper. Two American manufacturers make MPP; presently, a new manufacturer, Rigicon (Ronkonkoma NY), has recently begun to sell its MPP worldwide. Patient information forms submitted to the manufacturer between March 1, 2019, and December 8, 2022, were used to conduct an initial safety study for 605 first-time patients implanted with Rigicon10® by 46 physicians in 15 countries with a mean follow-up of 21.6 months. It has the same configuration of trimmable, paired silicone rods containing a twisted stainless-steel wire for bendability. However, it is available in six widths with hydrophilic coating compared to three widths offered by competitors. Revision or explantation was needed in 6 of 605 patients (0.99%) with half of those being removed for dissatisfaction (0.50%). Two (0.33%) suffered device infection and one (0.16%) required removal for erosion. Kaplan–Meier’s statistical analysis showed three-year implant survival from revision = 99.2%. It demonstrated a comparable safety record with less than 1.00% of patients requiring reoperation.
Mining multi-center heterogeneous medical data with distributed synthetic learning
Authors: Chang Qi , Yan Zhennan , Zhou Mu , Qu Hui , He Xiaoxiao , Zhang Han , Baskaran Lohendran , Al’Aref Subhi , Li Hongsheng , Zhang Shaoting , Metaxas Dimitris N.
Published: September 2023

Overcoming barriers on the use of multi-center data for medical analytics is challenging due to privacy protection and data heterogeneity in the healthcare system. In this study, we propose the Distributed Synthetic Learning (DSL) architecture to learn across multiple medical centers and ensure the protection of sensitive personal information. DSL enables the building of a homogeneous dataset with entirely synthetic medical images via a form of GAN-based synthetic learning. The proposed DSL architecture has the following key functionalities: multi-modality learning, missing modality completion learning, and continual learning. We systematically evaluate the performance of DSL on different medical applications using cardiac computed tomography angiography (CTA), brain tumor MRI, and histopathology nuclei datasets. Extensive experiments demonstrate the superior performance of DSL as a high-quality synthetic medical image provider by the use of an ideal synthetic quality metric called Dist-FID. We show that DSL can be adapted to heterogeneous data and remarkably outperforms the real misaligned modalities segmentation model by 55% and the temporal datasets segmentation model by 8%.
A generalizable Cas9/sgRNA prediction model using machine transfer learning with small high-quality datasets
Authors: Ham Dalton T. , Browne Tyler S. , Banglorewala Pooja N. , Wilson Tyler L. , Michael Richard K. , Gloor Gregory B. , Edgell David R.
Published: September 2023

The CRISPR/Cas9 nuclease from Streptococcus pyogenes (SpCas9) can be used with single guide RNAs (sgRNAs) as a sequence-specific antimicrobial agent and as a genome-engineering tool. However, current bacterial sgRNA activity models struggle with accurate predictions and do not generalize well, possibly because the underlying datasets used to train the models do not accurately measure SpCas9/sgRNA activity and cannot distinguish on-target cleavage from toxicity. Here, we solve this problem by using a two-plasmid positive selection system to generate high-quality data that more accurately reports on SpCas9/sgRNA cleavage and that separates activity from toxicity. We develop a machine learning architecture (crisprHAL) that can be trained on existing datasets, that shows marked improvements in sgRNA activity prediction accuracy when transfer learning is used with small amounts of high-quality data, and that can generalize predictions to different bacteria. The crisprHAL model recapitulates known SpCas9/sgRNA-target DNA interactions and provides a pathway to a generalizable sgRNA bacterial activity prediction tool that will enable accurate antimicrobial and genome engineering applications.
Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru
Authors: Leguia Mariana , Garcia-Glaessner Alejandra , Muñoz-Saavedra Breno , Juarez Diana , Barrera Patricia , Calvo-Mac Carlos , Jara Javier , Silva Walter , Ploog Karl , Amaro Lady , Colchao-Claux Paulo , Johnson Christine K. , Uhart Marcela M. , Nelson Martha I. , Lescano Jesus
Published: September 2023

Highly pathogenic avian influenza (HPAI) A/H5N1 viruses (lineage 2.3.4.4b) are rapidly invading the Americas, threatening wildlife, poultry, and potentially evolving into the next global pandemic. In November 2022 HPAI arrived in Peru, triggering massive pelican and sea lion die-offs. We report genomic characterization of HPAI/H5N1 in five species of marine mammals and seabirds (dolphins, sea lions, sanderlings, pelicans and cormorants). Peruvian viruses belong to lineage 2.3.4.4b, but they are 4:4 reassortants where 4 genomic segments (PA, HA, NA and MP) position within the Eurasian lineage that initially entered North America from Eurasia, while the other 4 genomic segments (PB2, PB1, NP and NS) position within the American lineage (clade C) that circulated in North America. These viruses are rapidly accruing mutations, including mutations of concern, that warrant further examination and highlight an urgent need for active local surveillance to manage outbreaks and limit spillover into other species, including humans.
Black carbon scavenging by low-level Arctic clouds
Authors: Zieger Paul , Heslin-Rees Dominic , Karlsson Linn , Koike Makoto , Modini Robin , Krejci Radovan
Published: September 2023

Black carbon (BC) from anthropogenic and natural sources has a pronounced climatic effect on the polar environment. The interaction of BC with low-level Arctic clouds, important for understanding BC deposition from the atmosphere, is studied using the first long-term observational data set of equivalent black carbon (eBC) inside and outside of clouds observed at Zeppelin Observatory, Svalbard. We show that the measured cloud residual eBC concentrations have a clear seasonal cycle with a maximum in early spring, due to the Arctic haze phenomenon, followed by cleaner summer months with very low concentrations. The scavenged fraction of eBC was positively correlated with the cloud water content and showed lower scavenged fractions at low temperatures, which may be due to mixed-phase cloud processes. A trajectory analysis revealed potential sources of eBC and the need to ensure that aerosol-cloud measurements are collocated, given the differences in air mass origin of cloudy and non-cloudy periods.
Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy
Authors: Ye Yansheng , Tyndall Erin R. , Bui Van , Bewley Maria C. , Wang Guifang , Hong Xupeng , Shen Yang , Flanagan John M. , Wang Hong-Gang , Tian Fang
Published: September 2023

Autophagosome formation, a crucial step in macroautophagy (autophagy), requires the covalent conjugation of LC3 proteins to the amino headgroup of phosphatidylethanolamine (PE) lipids. Atg3, an E2-like enzyme, catalyzes the transfer of LC3 from LC3-Atg3 to PEs in targeted membranes. Here we show that the catalytically important C-terminal regions of human Atg3 (hAtg3) are conformationally dynamic and directly interact with the membrane, in collaboration with its N-terminal membrane curvature-sensitive helix. The functional relevance of these interactions was confirmed by in vitro conjugation and in vivo cellular assays. Therefore, highly curved phagophoric rims not only serve as a geometric cue for hAtg3 recruitment, but also their interaction with hAtg3 promotes LC3-PE conjugation by targeting its catalytic center to the membrane surface and bringing substrates into proximity. Our studies advance the notion that autophagosome biogenesis is directly guided by the spatial interactions of Atg3 with highly curved phagophoric rims.
Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Authors: Brkic A. , Leibundgut M. , Jablonska J. , Zanki V. , Car Z. , Petrovic Perokovic V. , Marsavelski A. , Ban N. , Gruic-Sovulj I.
Published: September 2023

Antibiotics target key biological processes that include protein synthesis. Bacteria respond by developing resistance, which increases rapidly due to antibiotics overuse. Mupirocin, a clinically used natural antibiotic, inhibits isoleucyl-tRNA synthetase (IleRS), an enzyme that links isoleucine to its tRNAIle for protein synthesis. Two IleRSs, mupirocin-sensitive IleRS1 and resistant IleRS2, coexist in bacteria. The latter may also be found in resistant Staphylococcus aureus clinical isolates. Here, we describe the structural basis of mupirocin resistance and unravel a mechanism of hyper-resistance evolved by some IleRS2 proteins. We surprisingly find that an up to 103-fold increase in resistance originates from alteration of the HIGH motif, a signature motif of the class I aminoacyl-tRNA synthetases to which IleRSs belong. The structural analysis demonstrates how an altered HIGH motif could be adopted in IleRS2 but not IleRS1, providing insight into an elegant mechanism for coevolution of the key catalytic motif and associated antibiotic resistance.
Discovery of a three-proton insertion mechanism in α-molybdenum trioxide leading to enhanced charge storage capacity
Authors: Lei Yongjiu , Zhao Wenli , Yin Jun , Ma Yinchang , Zhao Zhiming , Yin Jian , Khan Yusuf , Hedhili Mohamed Nejib , Chen Long , Wang Qingxiao , Yuan Youyou , Zhang Xixiang , Bakr Osman M. , Mohammed Omar F. , Alshareef Husam N.
Published: September 2023

The α-molybdenum trioxide has attracted much attention for proton storage owing to its easily modified bilayer structure, fast proton insertion kinetics, and high theoretical specific capacity. However, the fundamental science of the proton insertion mechanism in α-molybdenum trioxide has not been fully understood. Herein, we uncover a three-proton intercalation mechanism in α-molybdenum trioxide using a specially designed phosphoric acid based liquid crystalline electrolyte. The semiconductor-to-metal transition behavior and the expansion of the lattice interlayers of α-molybdenum trioxide after trapping one mole of protons are verified experimentally and theoretically. Further investigation of the morphology of α-molybdenum trioxide indicates its fracture behavior upon the proton intercalation process, which creates diffusion channels for hydronium ions. Notably, the observation of an additional redox behavior at low potential endows α-molybdenum trioxide with an improved specific discharge capacity of 362 mAh g−1.
Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study
Authors: Zhu Zhaozhong , Li Yijun , Freishtat Robert J. , Celedón Juan C. , Espinola Janice A. , Harmon Brennan , Hahn Andrea , Camargo Carlos A. , Liang Liming , Hasegawa Kohei
Published: September 2023

Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized with bronchiolitis in a 17-center prospective study, and associate them with disease severity. We investigate differentially methylated CpGs (DMCs) for disease severity. We characterize the DMCs based on their association with cell and tissues types, biological pathways, and gene expression. Lastly, we also examine the relationships of severity-related DMCs with respiratory and immune traits in independent cohorts. We identify 33 DMCs associated with severity. These DMCs are differentially methylated in blood immune cells. These DMCs are also significantly enriched in multiple tissues (e.g., lung) and cells (e.g., small airway epithelial cells), and biological pathways (e.g., interleukin-1-mediated signaling). Additionally, these DMCs are associated with respiratory and immune traits (e.g., asthma, lung function, IgE levels). Our study suggests the role of DNA methylation in bronchiolitis severity.
Microgravity and evasion of plant innate immunity by human bacterial pathogens
Authors: Totsline Noah , Kniel Kalmia E. , Bais Harsh P.
Published: September 2023

Spaceflight microgravity and modeled-microgravity analogs (MMA) broadly alter gene expression and physiology in both pathogens and plants. Research elucidating plant and bacterial responses to normal gravity or microgravity has shown the involvement of both physiological and molecular mechanisms. Under true and simulated microgravity, plants display differential expression of pathogen-defense genes while human bacterial pathogens exhibit increased virulence, antibiotic resistance, stress tolerance, and reduced LD50 in animal hosts. Human bacterial pathogens including Salmonella enterica and E. coli act as cross-kingdom foodborne pathogens by evading and suppressing the innate immunity of plants for colonization of intracellular spaces. It is unknown if evasion and colonization of plants by human pathogens occurs under microgravity and if there is increased infection capability as demonstrated using animal hosts. Understanding the relationship between microgravity, plant immunity, and human pathogens could prevent potentially deadly outbreaks of foodborne disease during spaceflight. This review will summarize (1) alterations to the virulency of human pathogens under microgravity and MMA, (2) alterations to plant physiology and gene expression under microgravity and MMA, (3) suppression and evasion of plant immunity by human pathogens under normal gravity, (4) studies of plant-microbe interactions under microgravity and MMA. A conclusion suggests future study of interactions between plants and human pathogens under microgravity is beneficial to human safety, and an investment in humanity’s long and short-term space travel goals.
Melting of glacier ice enhanced by bursting air bubbles
Authors: Wengrove Meagan E. , Pettit Erin C. , Nash Jonathan D. , Jackson Rebecca H. , Skyllingstad Eric D.
Published: September 2023

Feedbacks between ice melt, glacier flow and ocean circulation can rapidly accelerate ice loss at tidewater glaciers and alter projections of sea-level rise. At the core of these projections is a model for ice melt that neglects the fact that glacier ice contains pressurized bubbles of air due to its formation from compressed snow. Current model estimates can underpredict glacier melt at termini outside the region influenced by the subglacial discharge plume by a factor of 10–100 compared with observations. Here we use laboratory-scale experiments and theoretical arguments to show that the bursting of pressurized bubbles from glacier ice could be a source of this discrepancy. These bubbles eject air into the seawater, delivering additional buoyancy and impulses of turbulent kinetic energy to the boundary layer, accelerating ice melt. We show that real glacier ice melts 2.25 times faster than clear bubble-free ice when driven by natural convection in a laboratory setting. We extend these results to the geophysical scale to show how bubble dynamics contribute to ice melt from tidewater glaciers. Consequently, these results could increase the accuracy of modelled predictions of ice loss to better constrain sea-level rise projections globally.
World’s human migration patterns in 2000–2019 unveiled by high-resolution data
Authors: Niva Venla , Horton Alexander , Virkki Vili , Heino Matias , Kosonen Maria , Kallio Marko , Kinnunen Pekka , Abel Guy J. , Muttarak Raya , Taka Maija , Varis Olli , Kummu Matti
Published: September 2023

Despite being a topical issue in public debate and on the political agenda for many countries, a global-scale, high-resolution quantification of migration and its major drivers for the recent decades remained missing. We created a global dataset of annual net migration between 2000 and 2019 (~10 km grid, covering the areas of 216 countries or sovereign states), based on reported and downscaled subnational birth (2,555 administrative units) and death (2,067 administrative units) rates. We show that, globally, around 50% of the world’s urban population lived in areas where migration accelerated urban population growth, while a third of the global population lived in provinces where rural areas experienced positive net migration. Finally, we show that, globally, socioeconomic factors are more strongly associated with migration patterns than climatic factors. While our method is dependent on census data, incurring notable uncertainties in regions where census data coverage or quality is low, we were able to capture migration patterns not only between but also within countries, as well as by socioeconomic and geophysical zonings. Our results highlight the importance of subnational analysis of migration—a necessity for policy design, international cooperation and shared responsibility for managing internal and international migration.