bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S7 from Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
Authors: Alvarez-Trotta Annamil , Guerrant William , Astudillo Luisana , Lahiry Mohini , Diluvio Giulia , Shersher Elena , Kaneku Hugo , Robbins David J. , Orton Darren , Capobianco Anthony J.
Published: April 2023

Off target profiling of NADI-351
Figure S5 from Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
Authors: Alvarez-Trotta Annamil , Guerrant William , Astudillo Luisana , Lahiry Mohini , Diluvio Giulia , Shersher Elena , Kaneku Hugo , Robbins David J. , Orton Darren , Capobianco Anthony J.
Published: April 2023

NADI-351 inhibits growth of Notch-dependent MDA-MD-231 and PC-3 xenografts and does not cause gross toxicity effecting mouse weight
Figure S4 from Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
Authors: Alvarez-Trotta Annamil , Guerrant William , Astudillo Luisana , Lahiry Mohini , Diluvio Giulia , Shersher Elena , Kaneku Hugo , Robbins David J. , Orton Darren , Capobianco Anthony J.
Published: April 2023

NADI-351 inhibits recruitment of Notch1 to the NTC and to the HES1 promoter
Table S6 from Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes
Authors: Apostolidi Maria , Vathiotis Ioannis A. , Muthusamy Viswanathan , Gaule Patricia , Gassaway Brandon M. , Rimm David L. , Rinehart Jesse
Published: April 2023

MaxQuant analysis of the PKM2 phosphopeptides detected after in vitro treatment with activated CDKs.
Table S2 from Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes
Authors: Apostolidi Maria , Vathiotis Ioannis A. , Muthusamy Viswanathan , Gaule Patricia , Gassaway Brandon M. , Rimm David L. , Rinehart Jesse
Published: April 2023

MaxQuant analysis of the PKM2 phosphopeptides detected in cell lines.
Figure S5 from Mesothelin-Specific CAR T Cells Target Ovarian Cancer
Authors: Schoutrop Esther , El-Serafi Ibrahim , Poiret Thomas , Zhao Ying , Gultekin Okan , He Rui , Moyano-Galceran Lidia , Carlson Joseph W. , Lehti Kaisa , Hassan Moustapha , Magalhaes Isabelle , Mattsson Jonas
Published: April 2023

Figure S5
Table S1 from Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance
Authors: Zhang Xu , Maity Tapan K. , Ross Karen E. , Qi Yue , Cultraro Constance M. , Bahta Meriam , Pitts Stephanie , Keswani Meghana , Gao Shaojian , Nguyen Khoa Dang P. , Cowart Julie , Kirkali Fatos , Wu Cathy , Guha Udayan
Published: April 2023

Table S1
Supplementary Material from Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance
Authors: Zhang Xu , Maity Tapan K. , Ross Karen E. , Qi Yue , Cultraro Constance M. , Bahta Meriam , Pitts Stephanie , Keswani Meghana , Gao Shaojian , Nguyen Khoa Dang P. , Cowart Julie , Kirkali Fatos , Wu Cathy , Guha Udayan
Published: April 2023

Supplementary Methods
Figure S9 from Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance
Authors: Zhang Xu , Maity Tapan K. , Ross Karen E. , Qi Yue , Cultraro Constance M. , Bahta Meriam , Pitts Stephanie , Keswani Meghana , Gao Shaojian , Nguyen Khoa Dang P. , Cowart Julie , Kirkali Fatos , Wu Cathy , Guha Udayan
Published: April 2023

Supplementary Fig.S9
Figure S1 from Mesothelin-Specific CAR T Cells Target Ovarian Cancer
Authors: Schoutrop Esther , El-Serafi Ibrahim , Poiret Thomas , Zhao Ying , Gultekin Okan , He Rui , Moyano-Galceran Lidia , Carlson Joseph W. , Lehti Kaisa , Hassan Moustapha , Magalhaes Isabelle , Mattsson Jonas
Published: April 2023

Figure S1
Figure S6 from Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance
Authors: Zhang Xu , Maity Tapan K. , Ross Karen E. , Qi Yue , Cultraro Constance M. , Bahta Meriam , Pitts Stephanie , Keswani Meghana , Gao Shaojian , Nguyen Khoa Dang P. , Cowart Julie , Kirkali Fatos , Wu Cathy , Guha Udayan
Published: April 2023

Supplementary Fig.S6
Supplementary Data from Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry
Authors: Sapkota Yadav , Qin Na , Ehrhardt Matthew J. , Wang Zhaoming , Chen Yan , Wilson Carmen L. , Estepp Jeremie , Rai Parul , Hankins Jane S. , Burridge Paul W. , Jefferies John L. , Zhang Jinghui , Hudson Melissa M. , Robison Leslie L. , Armstrong Gregory T. , Mulrooney Daniel A. , Yasui Yutaka
Published: April 2023

Supplementary Data
Figure S2 from Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance
Authors: Zhang Xu , Maity Tapan K. , Ross Karen E. , Qi Yue , Cultraro Constance M. , Bahta Meriam , Pitts Stephanie , Keswani Meghana , Gao Shaojian , Nguyen Khoa Dang P. , Cowart Julie , Kirkali Fatos , Wu Cathy , Guha Udayan
Published: April 2023

Supplementary Fig S2
Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
Authors: McDonald James I. , Diab Noor , Arthofer Elisa , Hadley Melissa , Kanholm Tomas , Rentia Uzma , Gomez Stephanie , Yu Angela , Grundy Erin E. , Cox Olivia , Topper Michael J. , Xing Xiaoyun , Strissel Pamela L. , Strick Reiner , Wang Ting , Baylin Stephen B. , Chiappinelli Katherine B.
Published: April 2023

Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
Supplementary Table S2 from The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy
Authors: Hirata Hidenari , Niida Atsushi , Kakiuchi Nobuyuki , Uchi Ryutaro , Sugimachi Keishi , Masuda Takaaki , Saito Tomoko , Kageyama Shun-Ichiro , Motomura Yushi , Ito Shuhei , Yoshitake Tadamasa , Tsurumaru Daisuke , Nishimuta Yusuke , Yokoyama Akira , Hasegawa Takanori , Chiba Kenichi , Shiraishi Yuichi , Du Junyan , Miura Fumihito , Morita Masaru , Toh Yasushi , Hirakawa Masakazu , Shioyama Yoshiyuki , Ito Takashi , Akimoto Tetsuo , Miyano Satoru , Shibata Tatsuhiro , Mori Masaki , Suzuki Yutaka , Ogawa Seishi , Ishigami Kousei , Mimori Koshi
Published: April 2023

Supplementary Table S2
Supplementary Figure S5 from The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy
Authors: Hirata Hidenari , Niida Atsushi , Kakiuchi Nobuyuki , Uchi Ryutaro , Sugimachi Keishi , Masuda Takaaki , Saito Tomoko , Kageyama Shun-Ichiro , Motomura Yushi , Ito Shuhei , Yoshitake Tadamasa , Tsurumaru Daisuke , Nishimuta Yusuke , Yokoyama Akira , Hasegawa Takanori , Chiba Kenichi , Shiraishi Yuichi , Du Junyan , Miura Fumihito , Morita Masaru , Toh Yasushi , Hirakawa Masakazu , Shioyama Yoshiyuki , Ito Takashi , Akimoto Tetsuo , Miyano Satoru , Shibata Tatsuhiro , Mori Masaki , Suzuki Yutaka , Ogawa Seishi , Ishigami Kousei , Mimori Koshi
Published: April 2023

Supplementary Figure S5 and legend
Supplementary Figure S3 from The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy
Authors: Hirata Hidenari , Niida Atsushi , Kakiuchi Nobuyuki , Uchi Ryutaro , Sugimachi Keishi , Masuda Takaaki , Saito Tomoko , Kageyama Shun-Ichiro , Motomura Yushi , Ito Shuhei , Yoshitake Tadamasa , Tsurumaru Daisuke , Nishimuta Yusuke , Yokoyama Akira , Hasegawa Takanori , Chiba Kenichi , Shiraishi Yuichi , Du Junyan , Miura Fumihito , Morita Masaru , Toh Yasushi , Hirakawa Masakazu , Shioyama Yoshiyuki , Ito Takashi , Akimoto Tetsuo , Miyano Satoru , Shibata Tatsuhiro , Mori Masaki , Suzuki Yutaka , Ogawa Seishi , Ishigami Kousei , Mimori Koshi
Published: April 2023

Supplementary Figure S3 and legend
Table S3 from ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression
Authors: Liu Cuicui , Qiang Jiankun , Deng Qiaodan , Xia Jie , Deng Lu , Zhou Lei , Wang Dong , He Xueyan , Liu Ying , Zhao Botao , Lv Jinhui , Yu Zuoren , Lei Qun-Ying , Shao Zhi-Ming , Zhang Xiao-Yong , Zhang Lixing , Liu Suling
Published: April 2023

The sequences of primers used for RT-qPCR
Table S1 from ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression
Authors: Liu Cuicui , Qiang Jiankun , Deng Qiaodan , Xia Jie , Deng Lu , Zhou Lei , Wang Dong , He Xueyan , Liu Ying , Zhao Botao , Lv Jinhui , Yu Zuoren , Lei Qun-Ying , Shao Zhi-Ming , Zhang Xiao-Yong , Zhang Lixing , Liu Suling
Published: April 2023

Antibodies used in this study
Supplementary Data from Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment
Authors: Wang Hui Qin , Mulford Iain J. , Sharp Fiona , Liang Jinsheng , Kurtulus Sema , Trabucco Gina , Quinn David S. , Longmire Tyler A. , Patel Nidhi , Patil Roshani , Shirley Matthew D. , Chen Yan , Wang Hao , Ruddy David A. , Fabre Claire , Williams Juliet A. , Hammerman Peter S. , Mataraza Jennifer , Platzer Barbara , Halilovic Ensar
Published: April 2023

Supplementary information containing six supplementary figures (Figure S1-S6), one supplementary table (Table S1) and supplementary materials and methods. Supplementary Figure S1. Flow cytometric gating strategies for analysis of intra-tumoral T cells in parental and p53KO Colon26 tumors. Supplementary Figure S2. Flow cytometric gating strategies for analysis of intra-tumoral myeloid cells in parental and p53KO Colon26 tumors. Supplementary Figure S3. Anti-tumor activity of HDM201 in Colon26 syngeneic tumor model requires intact immune system. Supplementary Figure S4. p53 knockout in Colon 26 cells results in loss of response to HDM201 in vitro and in vivo. Supplementary Figure S5. HDM201 in combination with PD-1/PD-L1 blockade enhances anti-tumor responses in p53 wild-type tumors, but not in KO tumors. Supplementary Figure S6. Flow cytometric analysis of CD80, GITR, PD-L1, and CD86 expression after HDM201 treatment in vitro. Supplementary Table S1. Antibodies for flow cytometry analysis.
Figure S2 from Characterizing Macrophage Diversity in Metastasis-Bearing Lungs Reveals a Lipid-Associated Macrophage Subset
Authors: Huggins Danielle N. , LaRue Rebecca S. , Wang Ying , Knutson Todd P. , Xu Yingzheng , Williams Jesse W. , Schwertfeger Kathryn L.
Published: April 2023

Figure S2 shows tumor growth curves and H&E staining in metastasis-bearing lungs for the tumor models studied. It also shows immunofluorescence staining of LAM.
Figure S1 from Characterizing Macrophage Diversity in Metastasis-Bearing Lungs Reveals a Lipid-Associated Macrophage Subset
Authors: Huggins Danielle N. , LaRue Rebecca S. , Wang Ying , Knutson Todd P. , Xu Yingzheng , Williams Jesse W. , Schwertfeger Kathryn L.
Published: April 2023

Figure S1 shows cell cycle analysis and analysis of macrophage clusters following scRNA-seq of a biological replicate.
Supplementary Data from Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors
Authors: Beetham Henry , Griffith Billie G.C. , Murina Olga , Loftus Alexander E.P. , Parry David A. , Temps Carolin , Culley Jayne , Muir Morwenna , Unciti-Broceta Asier , Sims Andrew H. , Byron Adam , Brunton Valerie G.
Published: April 2023

Supplementary Data from Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors
Supplementary Table S8 from Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL
Authors: Goldberg Liat , Negi Vijay , Chung Yang Jo , Onozawa Masahiro , Zhu Yuelin J. , Walker Robert L. , Pierce Rachel , Patel Daxesh P. , Krausz Kristopher W. , Gonzalez Frank J. , Goodell Margaret A. , Rodriguez Benjamin A.T. , Meltzer Paul S. , Aplan Peter D.
Published: April 2023

Gene sets
Supplementary Table S7 from Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL
Authors: Goldberg Liat , Negi Vijay , Chung Yang Jo , Onozawa Masahiro , Zhu Yuelin J. , Walker Robert L. , Pierce Rachel , Patel Daxesh P. , Krausz Kristopher W. , Gonzalez Frank J. , Goodell Margaret A. , Rodriguez Benjamin A.T. , Meltzer Paul S. , Aplan Peter D.
Published: April 2023

GO of differentially methylated enhancers.
Supplementary Tables from Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
Authors: Di Modica Martina , Gargari Giorgio , Regondi Viola , Bonizzi Arianna , Arioli Stefania , Belmonte Beatrice , De Cecco Loris , Fasano Elena , Bianchi Francesca , Bertolotti Alessia , Tripodo Claudio , Villani Laura , Corsi Fabio , Guglielmetti Simone , Balsari Andrea , Triulzi Tiziana , Tagliabue Elda
Published: April 2023

Supplementary Table S2-S4. Pathway enrichment analysis by DAVID and GSEA in the ileum and colon of antibiotic treated mice.
Supplementary table 8 from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3
Authors: Mocci Evelina , Kundu Prosenjit , Wheeler William , Arslan Alan A. , Beane-Freeman Laura E. , Bracci Paige M. , Brennan Paul , Canzian Federico , Du Mengmeng , Gallinger Steven , Giles Graham G. , Goodman Phyllis J. , Kooperberg Charles , Le Marchand Loic , Neale Rachel E. , Shu Xiao-Ou , Visvanathan Kala , White Emily , Zheng Wei , Albanes Demetrius , Andreotti Gabriella , Babic Ana , Bamlet William R. , Berndt Sonja I. , Blackford Amanda L. , Bueno-de-Mesquita Bas , Buring Julie E. , Campa Daniele , Chanock Stephen J. , Childs Erica J. , Duell Eric J. , Fuchs Charles S. , Gaziano J. Michael , Giovannucci Edward L. , Goggins Michael G. , Hartge Patricia , Hassan Manal M. , Holly Elizabeth A. , Hoover Robert N. , Hung Rayjean J. , Kurtz Robert C. , Lee I-Min , Malats Núria , Milne Roger L. , Ng Kimmie , Oberg Ann L. , Panico Salvatore , Peters Ulrike , Porta Miquel , Rabe Kari G. , Riboli Elio , Rothman Nathaniel , Scelo Ghislaine , Sesso Howard D. , Silverman Debra T. , Stevens Victoria L. , Strobel Oliver , Thompson Ian M. , Tjonneland Anne , Trichopoulou Antonia , Van Den Eeden Stephen K. , Wactawski-Wende Jean , Wentzensen Nicolas , Wilkens Lynne R. , Yu Herbert , Yuan Fangcheng , Zeleniuch-Jacquotte Anne , Amundadottir Laufey T. , Li Donghui , Jacobs Eric J. , Petersen Gloria M. , Wolpin Brian M. , Risch Harvey A. , Kraft Peter , Chatterjee Nilanjan , Klein Alison P. , Stolzenberg-Solomon Rachael
Published: April 2023

Supplemental Table 8. Enrichment in regulatory regions for rs842357 and related SNPs
Supplementary Data from PKM2 Is Essential for Bladder Cancer Growth and Maintenance
Authors: Xia Yong , Wang Xing , Liu Yan , Shapiro Ellen , Lepor Herbert , Tang Moon-Shong , Sun Tung-Tien , Wu Xue-Ru
Published: April 2023

Supplementary Data from PKM2 Is Essential for Bladder Cancer Growth and Maintenance
Supplementary Data from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3
Authors: Mocci Evelina , Kundu Prosenjit , Wheeler William , Arslan Alan A. , Beane-Freeman Laura E. , Bracci Paige M. , Brennan Paul , Canzian Federico , Du Mengmeng , Gallinger Steven , Giles Graham G. , Goodman Phyllis J. , Kooperberg Charles , Le Marchand Loic , Neale Rachel E. , Shu Xiao-Ou , Visvanathan Kala , White Emily , Zheng Wei , Albanes Demetrius , Andreotti Gabriella , Babic Ana , Bamlet William R. , Berndt Sonja I. , Blackford Amanda L. , Bueno-de-Mesquita Bas , Buring Julie E. , Campa Daniele , Chanock Stephen J. , Childs Erica J. , Duell Eric J. , Fuchs Charles S. , Gaziano J. Michael , Giovannucci Edward L. , Goggins Michael G. , Hartge Patricia , Hassan Manal M. , Holly Elizabeth A. , Hoover Robert N. , Hung Rayjean J. , Kurtz Robert C. , Lee I-Min , Malats Núria , Milne Roger L. , Ng Kimmie , Oberg Ann L. , Panico Salvatore , Peters Ulrike , Porta Miquel , Rabe Kari G. , Riboli Elio , Rothman Nathaniel , Scelo Ghislaine , Sesso Howard D. , Silverman Debra T. , Stevens Victoria L. , Strobel Oliver , Thompson Ian M. , Tjonneland Anne , Trichopoulou Antonia , Van Den Eeden Stephen K. , Wactawski-Wende Jean , Wentzensen Nicolas , Wilkens Lynne R. , Yu Herbert , Yuan Fangcheng , Zeleniuch-Jacquotte Anne , Amundadottir Laufey T. , Li Donghui , Jacobs Eric J. , Petersen Gloria M. , Wolpin Brian M. , Risch Harvey A. , Kraft Peter , Chatterjee Nilanjan , Klein Alison P. , Stolzenberg-Solomon Rachael
Published: April 2023

Supplemental figures 1 and 2. Supplemental tables 1-7.
Supplementary Data from Activation of Notch and Myc Signaling via B-cell–Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia
Authors: Biran Anat , Yin Shanye , Kretzmer Helene , ten Hacken Elisa , Parvin Salma , Lucas Fabienne , Uduman Mohamed , Gutierrez Catherine , Dangle Nathan , Billington Leah , Regis Fara Faye , Rassenti Laura Z. , Mohammad Arman , Hoffmann Gabriela Brunsting , Stevenson Kristen , Zheng Mei , Witten Elizabeth , Fernandes Stacey M. , Tausch Eugen , Sun Clare , Stilgenbauer Stephan , Brown Jennifer R. , Kipps Thomas J. , Aster John C. , Gnirke Andreas , Neuberg Donna S. , Letai Anthony , Wang Lili , Carrasco Ruben D. , Meissner Alexander , Wu Catherine J.
Published: April 2023

Supplementary Materials and Methods and Supplementary Figures S1-4
Supplementary Movie Legends from Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress
Authors: Ren Jinghua , He Jiayi , Zhang Hongji , Xia Yujia , Hu Zhiwei , Loughran Patricia , Billiar Timothy , Huang Hai , Tsung Allan
Published: April 2023

Supplementary Movie Legends
Supplementary Data from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth
Authors: Cook Danielle R. , Kang Melissa , Martin Timothy D. , Galanko Joseph A. , Loeza Gabriela H. , Trembath Dimitri G. , Justilien Verline , Pickering Karen A. , Vincent David F. , Jarosch Armin , Jurmeister Philipp , Waters Andrew M. , Hibshman Priya S. , Campbell Andrew D. , Ford Catriona A. , Keku Temitope O. , Yeh Jen Jen , Lee Michael S. , Cox Adrienne D. , Fields Alan P. , Sandler Robert S. , Sansom Owen J. , Sers Christine , Schaefer Antje , Der Channing J.
Published: April 2023

Supplementary Tables and Methods.
Supplementary information from Genetic Risk for Overall Cancer and the Benefit of Adherence to a Healthy Lifestyle
Authors: Zhu Meng , Wang Tianpei , Huang Yanqian , Zhao Xiaoyu , Ding Yuqing , Zhu Mengyi , Ji Mengmeng , Wang Cheng , Dai Juncheng , Yin Rong , Xu Lin , Ma Hongxia , Wei Qingyi , Jin Guangfu , Hu Zhibin , Shen Hongbing
Published: April 2023

Supplementary methods, supplementary tables and supplementary figures.
Supplementary Figure 3 from Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress
Authors: Ren Jinghua , He Jiayi , Zhang Hongji , Xia Yujia , Hu Zhiwei , Loughran Patricia , Billiar Timothy , Huang Hai , Tsung Allan
Published: April 2023

Adoptive transfer of platelets from TLR4-/- mice diminishes surgical stress-induced metastatic colonization.
Supplementary Figure 2 from Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress
Authors: Ren Jinghua , He Jiayi , Zhang Hongji , Xia Yujia , Hu Zhiwei , Loughran Patricia , Billiar Timothy , Huang Hai , Tsung Allan
Published: April 2023

Activation of platelets under hepatic I/R stress is platelet integrin-dependent but not P-selectin-dependent.
Supplementary Data from Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer
Authors: Ray Upasana , Jung Deok-Beom , Jin Ling , Xiao Yinan , Dasari Subramanyam , Sarkar Bhattacharya Sayantani , Thirusangu Prabhu , Staub Julie K. , Roy Debarshi , Roy Bhaskar , Weroha S. John , Hou Xiaonan , Purcell James W. , Bakkum-Gamez Jamie N. , Kaufmann Scott H. , Kannan Nagarajan , Mitra Anirban K. , Shridhar Viji
Published: April 2023

Supplementary Data from Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer
Supplementary Figure S6 from Hepatitis B–Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation
Authors: Zhang Changlu , Gao Yanan , Du Chengzhi , Markowitz Geoffrey J. , Fu Jing , Zhang Zhenxing , Liu Chunliang , Qin Wenhao , Wang Hongyang , Wang Fan , Yang Pengyuan
Published: April 2023

Supplementary Figure S6 shows IL-8-CXCR1 does not affect the infiltration of macrophages and MDSCs in the orthotopic model
Supplementary Figure S5 from Hepatitis B–Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation
Authors: Zhang Changlu , Gao Yanan , Du Chengzhi , Markowitz Geoffrey J. , Fu Jing , Zhang Zhenxing , Liu Chunliang , Qin Wenhao , Wang Hongyang , Wang Fan , Yang Pengyuan
Published: April 2023

Supplementary Figure S5 shows IL-8-CXCR1 axis creates an immunosuppressive microenvironment in the liver
Table S1 from ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma
Authors: Aguirre-Portolés Cristina , Payne Riley , Trautz Aspen , Foskett J. Kevin , Natale Christopher A. , Seykora John T. , Ridky Todd W.
Published: April 2023

Features of the human derived melanoma cells used across this study.
Supplementary Figure 7 from ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma
Authors: Aguirre-Portolés Cristina , Payne Riley , Trautz Aspen , Foskett J. Kevin , Natale Christopher A. , Seykora John T. , Ridky Todd W.
Published: April 2023

Pharmacologic ZIP9 blockade inhibits melanoma in vivo
Supplementary Figure 6 from ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma
Authors: Aguirre-Portolés Cristina , Payne Riley , Trautz Aspen , Foskett J. Kevin , Natale Christopher A. , Seykora John T. , Ridky Todd W.
Published: April 2023

Pharmacologic ZIP9 blockade inhibits melanoma in vitro
Supplementary Figure 5 from ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma
Authors: Aguirre-Portolés Cristina , Payne Riley , Trautz Aspen , Foskett J. Kevin , Natale Christopher A. , Seykora John T. , Ridky Todd W.
Published: April 2023

Testosterone driven increase in melanoma proliferation requires ZIP9 and activation of MAPK and YAP1
Supplementary Figure 3 from ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma
Authors: Aguirre-Portolés Cristina , Payne Riley , Trautz Aspen , Foskett J. Kevin , Natale Christopher A. , Seykora John T. , Ridky Todd W.
Published: April 2023

ZIP9 expression and overall survival in melanoma patients. Correlation between ZIP9 expression and clinical features in melanoma patients.
Figure S5 from Human Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma
Authors: Maze Emmanuel A. , Agit Bora , Reeves Shona , Hilton David A. , Parkinson David B. , Laraba Liyam , Ercolano Emanuela , Kurian Kathreena M. , Hanemann C. Oliver , Belshaw Robert D. , Ammoun Sylwia
Published: April 2023

Figure S5
Figure S5 and legend
Supplementary Material from STIM1 Mediates Calcium-Dependent Epigenetic Reprogramming in Pancreatic Cancer
Authors: Kutschat Ana P. , Hamdan Feda H. , Wang Xin , Wixom Alexander Q. , Najafova Zeynab , Gibhardt Christine S. , Kopp Waltraut , Gaedcke Jochen , Ströbel Philipp , Ellenrieder Volker , Bogeski Ivan , Hessmann Elisabeth , Johnsen Steven A.
Published: April 2023

Supplementary Materials & Methods, Supplementary Tables S1-S3.
Figure S2 from Human Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma
Authors: Maze Emmanuel A. , Agit Bora , Reeves Shona , Hilton David A. , Parkinson David B. , Laraba Liyam , Ercolano Emanuela , Kurian Kathreena M. , Hanemann C. Oliver , Belshaw Robert D. , Ammoun Sylwia
Published: April 2023

Figure S2
Figure S2 and figure legend
Supplementary Table 3 from Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Authors: Stosic Ana , Fuligni Fabio , Anderson Nathaniel D. , Davidson Scott , de Borja Richard , Acker Meryl , Forte Vito , Campisi Paolo , Propst Evan J. , Wolter Nikolaus E. , Chami Rose , Mete Ozgur , Malkin David , Shlien Adam , Wasserman Jonathan D.
Published: April 2023

Gene Expression Clusters, Gene Ontology and KEGG Gene Set Enrichment by Cluster
Supplementary Table 2 from Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Authors: Stosic Ana , Fuligni Fabio , Anderson Nathaniel D. , Davidson Scott , de Borja Richard , Acker Meryl , Forte Vito , Campisi Paolo , Propst Evan J. , Wolter Nikolaus E. , Chami Rose , Mete Ozgur , Malkin David , Shlien Adam , Wasserman Jonathan D.
Published: April 2023

Demographics and Oncogenic Variants for Tumors evaluated by WES/RNASeq. NA-Not applicable (infiltrative tumors without defined borders)
Supplementary Figure 4 from Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Authors: Stosic Ana , Fuligni Fabio , Anderson Nathaniel D. , Davidson Scott , de Borja Richard , Acker Meryl , Forte Vito , Campisi Paolo , Propst Evan J. , Wolter Nikolaus E. , Chami Rose , Mete Ozgur , Malkin David , Shlien Adam , Wasserman Jonathan D.
Published: April 2023

Distribution of Histologic Variants by Oncogenic Variant Class or Gene Expression Cluster
Supplementary Figure 1 from Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Authors: Stosic Ana , Fuligni Fabio , Anderson Nathaniel D. , Davidson Scott , de Borja Richard , Acker Meryl , Forte Vito , Campisi Paolo , Propst Evan J. , Wolter Nikolaus E. , Chami Rose , Mete Ozgur , Malkin David , Shlien Adam , Wasserman Jonathan D.
Published: April 2023

Determination of cluster numbers by Elbow and Gap Statistic Modeling
SupplementaryMethods.docx from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth
Authors: Geethadevi Anjali , Nair Ajay , Parashar Deepak , Ku Zhiqiang , Xiong Wei , Deng Hui , Li Yongsheng , George Jasmine , McAllister Donna M. , Sun Yunguang , Kadamberi Ishaque P. , Gupta Prachi , Dwinell Michael B. , Bradley William H. , Rader Janet S. , Rui Hallgeir , Schwabe Robert F. , Zhang Ningyan , Pradeep Sunila , An Zhiqiang , Chaluvally-Raghavan Pradeep
Published: April 2023

SupplementaryMethods.docx from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth
Supplementary Information from Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype
Authors: Nishida-Aoki Nao , Gujral Taranjit S.
Published: April 2023

Supplementary Information
Supplementary Figures and Methods
Supplementary Table from Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk
Authors: Boonen Rick A.C.M. , Wiegant Wouter W. , Celosse Nandi , Vroling Bas , Heijl Stephan , Kote-Jarai Zsofia , Mijuskovic Martina , Cristea Simona , Solleveld-Westerink Nienke , van Wezel Tom , Beerenwinkel Niko , Eeles Rosalind , Devilee Peter , Vreeswijk Maaike P.G. , Marra Giancarlo , van Attikum Haico
Published: April 2023

Supplementary Table from Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk
Supplementary Figure from Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Authors: Fernandez Mario R. , Schaub Franz X. , Yang Chunying , Li Weimin , Yun Seongseok , Schaub Stephanie K. , Dorsey Frank C. , Liu Min , Steeves Meredith A. , Ballabio Andrea , Tzankov Alexandar , Chen Zhihua , Koomen John M. , Berglund Anders E. , Cleveland John L.
Published: April 2023

Supplementary Figure from Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Supplementary Data from Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Authors: Fernandez Mario R. , Schaub Franz X. , Yang Chunying , Li Weimin , Yun Seongseok , Schaub Stephanie K. , Dorsey Frank C. , Liu Min , Steeves Meredith A. , Ballabio Andrea , Tzankov Alexandar , Chen Zhihua , Koomen John M. , Berglund Anders E. , Cleveland John L.
Published: April 2023

Supplementary Data from Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Supplementary Data from Myeloid-Derived Suppressive Cell Expansion Promotes Melanoma Growth and Autoimmunity by Inhibiting CD40/IL27 Regulation in Macrophages
Authors: Valencia Julio C. , Erwin-Cohen Rebecca A. , Clavijo Paul E. , Allen Clint , Sanford Michael E. , Day Chi-Ping , Hess Megan M. , Johnson Morgan , Yin Jie , Fenimore John M. , Bettencourt Ian A. , Tsuneyama Koichi , Romero Maria E. , Klarmann Kimberly D. , Jiang Peng , Bae Heekyong R. , McVicar Daniel W. , Merlino Glenn , Edmondson Elijah F. , Anandasabapathy Niroshana , Young Howard A.
Published: April 2023

Supplementary data, including supplementary figures with figure legends below
Supplementary Figure from M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression
Authors: Yadav Pooja , Subbarayalu Panneerdoss , Medina Daisy , Nirzhor Saif , Timilsina Santosh , Rajamanickam Subapriya , Eedunuri Vijay K. , Gupta Yogesh , Zheng Siyuan , Abdelfattah Nourhan , Huang Yufei , Vadlamudi Ratna , Hromas Robert , Meltzer Paul , Houghton Peter , Chen Yidong , Rao Manjeet K.
Published: April 2023

Supplementary Figure from M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression
Supplementary Data from Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types
Authors: Sinha Neelam , Sinha Sanju , Valero Cristina , Schäffer Alejandro A. , Aldape Kenneth , Litchfield Kevin , Chan Timothy A. , Morris Luc G.T. , Ruppin Eytan
Published: April 2023

Supplementary Data from Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types
Supplementary Data from M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression
Authors: Yadav Pooja , Subbarayalu Panneerdoss , Medina Daisy , Nirzhor Saif , Timilsina Santosh , Rajamanickam Subapriya , Eedunuri Vijay K. , Gupta Yogesh , Zheng Siyuan , Abdelfattah Nourhan , Huang Yufei , Vadlamudi Ratna , Hromas Robert , Meltzer Paul , Houghton Peter , Chen Yidong , Rao Manjeet K.
Published: April 2023

Supplementary Data from M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression
Table S8 from The Protein Kinase Activity of NME7 Activates Wnt/β-Catenin Signaling to Promote One-Carbon Metabolism in Hepatocellular Carcinoma
Authors: Ren Xinxin , Rong Zhuoxian , Liu Xiaoyu , Gao Jie , Xu Xu , Zi Yuyuan , Mu Yun , Guan Yidi , Cao Zhen , Zhang Yuefang , Zeng Zimei , Fan Qi , Wang Xitao , Pei Qian , Wang Xiang , Xin Haiguang , Li Zhi , Nie Yingjie , Qiu Zilong , Li Nan , Sun Lunquan , Deng Yuezhen
Published: April 2023

Supplemental Table 8 Correlation between the protein level of MTHFD2 and the clinical features of patients with HCC in the tissue array.
Table S4 from The Protein Kinase Activity of NME7 Activates Wnt/β-Catenin Signaling to Promote One-Carbon Metabolism in Hepatocellular Carcinoma
Authors: Ren Xinxin , Rong Zhuoxian , Liu Xiaoyu , Gao Jie , Xu Xu , Zi Yuyuan , Mu Yun , Guan Yidi , Cao Zhen , Zhang Yuefang , Zeng Zimei , Fan Qi , Wang Xitao , Pei Qian , Wang Xiang , Xin Haiguang , Li Zhi , Nie Yingjie , Qiu Zilong , Li Nan , Sun Lunquan , Deng Yuezhen
Published: April 2023

Supplemental Table 4 Correlation between the mRNA level of NME7 and the clinical features of HCC.
Supplementary Table from Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution
Authors: Wang Xiansong , Hu Wei , Li Xiangchun , Huang Dan , Li Qing , Chan Hung , Zeng Judeng , Xie Chuan , Chen Huarong , Liu Xiaodong , Gin Tony , Wang Maggie Haitian , Cheng Alfred Sze Lok , Kang Wei , To Ka-Fai , Plewczynski Dariusz , Zhang Qingpeng , Chen Xiaoting , Chan Danny Cheuk Wing , Ko Ho , Wong Sunny Hei , Yu Jun , Chan Matthew Tak Vai , Zhang Lin , Wu William Ka Kei
Published: April 2023

Supplementary Table from Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution
Supplementary Figure from Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution
Authors: Wang Xiansong , Hu Wei , Li Xiangchun , Huang Dan , Li Qing , Chan Hung , Zeng Judeng , Xie Chuan , Chen Huarong , Liu Xiaodong , Gin Tony , Wang Maggie Haitian , Cheng Alfred Sze Lok , Kang Wei , To Ka-Fai , Plewczynski Dariusz , Zhang Qingpeng , Chen Xiaoting , Chan Danny Cheuk Wing , Ko Ho , Wong Sunny Hei , Yu Jun , Chan Matthew Tak Vai , Zhang Lin , Wu William Ka Kei
Published: April 2023

Supplementary Figure from Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution
Table S1 from The Protein Kinase Activity of NME7 Activates Wnt/β-Catenin Signaling to Promote One-Carbon Metabolism in Hepatocellular Carcinoma
Authors: Ren Xinxin , Rong Zhuoxian , Liu Xiaoyu , Gao Jie , Xu Xu , Zi Yuyuan , Mu Yun , Guan Yidi , Cao Zhen , Zhang Yuefang , Zeng Zimei , Fan Qi , Wang Xitao , Pei Qian , Wang Xiang , Xin Haiguang , Li Zhi , Nie Yingjie , Qiu Zilong , Li Nan , Sun Lunquan , Deng Yuezhen
Published: April 2023

Supplemental Table 1 The primer sequences for qPCR and shRNA.
Supplementary Table from Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis
Authors: Elwakeel Eiman , Brüggemann Mirko , Wagih Jessica , Lityagina Olga , Elewa Mohammed A.F. , Han Yingying , Frömel Timo , Popp Rüdiger , Nicolas Adele M. , Schreiber Yannick , Gradhand Elise , Thomas Dominique , Nüsing Rolf , Steinmetz-Späh Julia , Savai Rajkumar , Fokas Emmanouil , Fleming Ingrid , Greten Florian R. , Zarnack Kathi , Brüne Bernhard , Weigert Andreas
Published: April 2023

Supplementary Table from Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis
Supplementary Table from Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3
Authors: Liao Long , He Yan , Li Shu-Jun , Zhang Guo-Geng , Yu Wei , Yang Jing , Huang Zi-Jia , Zheng Can-Can , He Qing-Yu , Li Yan , Li Bin
Published: April 2023

Supplementary Table from Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3
Supplementary Figure from Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3
Authors: Liao Long , He Yan , Li Shu-Jun , Zhang Guo-Geng , Yu Wei , Yang Jing , Huang Zi-Jia , Zheng Can-Can , He Qing-Yu , Li Yan , Li Bin
Published: April 2023

Supplementary Figure from Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3
Supplementary Table from Gain of Chromosome 1q Perturbs a Competitive Endogenous RNA Network to Promote Melanoma Metastasis
Authors: Xu Xiaonan , Wang Kaizhen , Vera Olga , Verma Akanksha , Jasani Neel , Bok Ilah , Elemento Olivier , Du Dongliang , Yu Xiaoqing , Karreth Florian A.
Published: April 2023

Supplementary Table from Gain of Chromosome 1q Perturbs a Competitive Endogenous RNA Network to Promote Melanoma Metastasis
Supplementary Figure from Gain of Chromosome 1q Perturbs a Competitive Endogenous RNA Network to Promote Melanoma Metastasis
Authors: Xu Xiaonan , Wang Kaizhen , Vera Olga , Verma Akanksha , Jasani Neel , Bok Ilah , Elemento Olivier , Du Dongliang , Yu Xiaoqing , Karreth Florian A.
Published: April 2023

Supplementary Figure from Gain of Chromosome 1q Perturbs a Competitive Endogenous RNA Network to Promote Melanoma Metastasis
Supplementary Table from Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6
Authors: Sorokin Alexey V. , Kanikarla Marie Preeti , Bitner Lea , Syed Muddassir , Woods Melanie , Manyam Ganiraju , Kwong Lawrence N. , Johnson Benny , Morris Van K. , Jones Philip , Menter David G. , Lee Michael S. , Kopetz Scott
Published: April 2023

Supplementary Table from Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6
Supplementary Data from The X-Linked Helicase DDX3X Is Required for Lymphoid Differentiation and MYC-Driven Lymphomagenesis
Authors: Lacroix Marion , Beauchemin Hugues , Fraszczak Jennifer , Ross Julie , Shooshtarizadeh Peiman , Chen Riyan , Möröy Tarik
Published: April 2023

Supplementary Data from The X-Linked Helicase DDX3X Is Required for Lymphoid Differentiation and MYC-Driven Lymphomagenesis
Figure SF3 from Regulatory Network of PD1 Signaling Is Associated with Prognosis in Glioblastoma Multiforme
Authors: Lopes-Ramos Camila M. , Belova Tatiana , Brunner Tess H. , Ben Guebila Marouen , Osorio Daniel , Quackenbush John , Kuijjer Marieke L.
Published: April 2023

To ensure that our results were stable across multiple survival thresholds, we repeated the comparative network analysis in the two discovery datasets across multiple survival thresholds, which we ranged from zero to the maximum follow-up, with intervals of 0.1 years, keeping comparisons that had group sizes of at least ten patients. This figure reports the -log10FDR and GSEA enrichment scores (ES) for the different thresholds, for A) discovery dataset 1 and B) discovery dataset 2. Significant results (FDR<0.05) are highlighted with red circles.
Figure SF2 from Regulatory Network of PD1 Signaling Is Associated with Prognosis in Glioblastoma Multiforme
Authors: Lopes-Ramos Camila M. , Belova Tatiana , Brunner Tess H. , Ben Guebila Marouen , Osorio Daniel , Quackenbush John , Kuijjer Marieke L.
Published: April 2023

Differential network topology contrasting the short-term with the long-term survival network. A) Differential network modules significantly enriched for overrepresentation of Gene Ontology terms. Modules are shown for both discovery datasets (D1 and D2). Two modules were significant in both dataset (indicated with M1 and M2). The color in the heatmap indicates the enrichment of genes in the module as observed/expected value (Obs/Exp), with purple representing enriched modules in discovery dataset 1 and green enriched modules in discovery dataset 2. B) "Beeswarm" plot visualizing the distribution of average log differential modularity scores from ALPACA, for transcription factors (TF) and genes (Gene). Higher scores mean higher differential modularity. TFs and genes with significant differential modularity between the two survival groups are labeled.
Figure SF1 from Regulatory Network of PD1 Signaling Is Associated with Prognosis in Glioblastoma Multiforme
Authors: Lopes-Ramos Camila M. , Belova Tatiana , Brunner Tess H. , Ben Guebila Marouen , Osorio Daniel , Quackenbush John , Kuijjer Marieke L.
Published: April 2023

Smooth scatterplot visualizing the correlation between edge weights in the condition-specific network modeled on discovery dataset 1 and the condition-specific network modeled on discovery dataset 2. Pearson correlation coefficient (R) and p-value (p) are indicated in the plot.
Supplementary Materials and Methods from N6-methyladenosine–Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression
Authors: Deng Junge , Zhang Jialiang , Ye Ying , Liu Kaijing , Zeng Lingxing , Huang Jingyi , Pan Ling , Li Mei , Bai Ruihong , Zhuang Lisha , Huang Xudong , Wu Guandi , Wei Lusheng , Zheng Yanfen , Su Jiachun , Zhang Shaoping , Chen Rufu , Lin Dongxin , Zheng Jian
Published: April 2023

Supplementary Materials and Methods
Supplementary Figures from N6-methyladenosine–Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression
Authors: Deng Junge , Zhang Jialiang , Ye Ying , Liu Kaijing , Zeng Lingxing , Huang Jingyi , Pan Ling , Li Mei , Bai Ruihong , Zhuang Lisha , Huang Xudong , Wu Guandi , Wei Lusheng , Zheng Yanfen , Su Jiachun , Zhang Shaoping , Chen Rufu , Lin Dongxin , Zheng Jian
Published: April 2023

Supplementary Figure S1-S6 and corresponding Supplementary Figure legends
Figure S3 from Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib
Authors: Han Han , Li Shuai , Chen Ting , Fitzgerald Michael , Liu Shengwu , Peng Chengwei , Tang Kwan Ho , Cao Shougen , Chouitar Johara , Wu Jiansheng , Peng David , Deng Jiehui , Gao Zhendong , Baker Theresa E. , Li Fei , Zhang Hua , Pan Yuanwang , Ding Hailin , Hu Hai , Pyon Val , Thakurdin Cassandra , Papadopoulos Eleni , Tang Sittinon , Gonzalvez Francois , Chen Haiquan , Rivera Victor M. , Brake Rachael , Vincent Sylvie , Wong Kwok-Kin
Published: April 2023

Figure S3
Supplementary Figures and Tables from Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets
Authors: Khorsandi Shirin Elizabeth , Dokal Arran D. , Rajeeve Vinothini , Britton David J. , Illingworth Megan S. , Heaton Nigel , Cutillas Pedro R.
Published: April 2023

Supplementary Figures (S1A-B, S2, S3, S4A-C and Table S1 & S2.
Table S5 from Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance
Authors: Liu Jianglan , Rebecca Vito W. , Kossenkov Andrew V. , Connelly Thomas , Liu Qin , Gutierrez Alexis , Xiao Min , Li Ling , Zhang Gao , Samarkina Anastasia , Zayasbazan Delaine , Zhang Jie , Cheng Chaoran , Wei Zhi , Alicea Gretchen M. , Fukunaga-Kalabis Mizuho , Krepler Clemens , Aza-Blanc Pedro , Yang Chih-Cheng , Delvadia Bela , Tong Cynthia , Huang Ye , Delvadia Maya , Morias Alice S. , Sproesser Katrin , Brafford Patricia , Wang Joshua X. , Beqiri Marilda , Somasundaram Rajasekharan , Vultur Adina , Hristova Denitsa M. , Wu Lawrence W. , Lu Yiling , Mills Gordon B. , Xu Wei , Karakousis Giorgos C. , Xu Xiaowei , Schuchter Lynn M. , Mitchell Tara C. , Amaravadi Ravi K. , Kwong Lawrence N. , Frederick Dennie T. , Boland Genevieve M. , Salvino Joseph M. , Speicher David W. , Flaherty Keith T. , Ronai Ze'ev A. , Herlyn Meenhard
Published: April 2023

Supplementary Table
Supplementary Data from MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Authors: Sanjiv Kumar , Calderón-Montaño José Manuel , Pham Therese M. , Erkers Tom , Tsuber Viktoriia , Almlöf Ingrid , Höglund Andreas , Heshmati Yaser , Seashore-Ludlow Brinton , Nagesh Danda Akhilesh , Gad Helge , Wiita Elisee , Göktürk Camilla , Rasti Azita , Friedrich Stefanie , Centio Anders , Estruch Montserrat , Våtsveen Thea Kristin , Struyf Nona , Visnes Torkild , Scobie Martin , Koolmeister Tobias , Henriksson Martin , Wallner Olov , Sandvall Teresa , Lehmann Sören , Theilgaard-Mönch Kim , Garnett Mathew J. , Östling Päivi , Walfridsson Julian , Helleday Thomas , Warpman Berglund Ulrika
Published: April 2023

Supplementary figures and tables and material and methods
Table S2 from Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance
Authors: Liu Jianglan , Rebecca Vito W. , Kossenkov Andrew V. , Connelly Thomas , Liu Qin , Gutierrez Alexis , Xiao Min , Li Ling , Zhang Gao , Samarkina Anastasia , Zayasbazan Delaine , Zhang Jie , Cheng Chaoran , Wei Zhi , Alicea Gretchen M. , Fukunaga-Kalabis Mizuho , Krepler Clemens , Aza-Blanc Pedro , Yang Chih-Cheng , Delvadia Bela , Tong Cynthia , Huang Ye , Delvadia Maya , Morias Alice S. , Sproesser Katrin , Brafford Patricia , Wang Joshua X. , Beqiri Marilda , Somasundaram Rajasekharan , Vultur Adina , Hristova Denitsa M. , Wu Lawrence W. , Lu Yiling , Mills Gordon B. , Xu Wei , Karakousis Giorgos C. , Xu Xiaowei , Schuchter Lynn M. , Mitchell Tara C. , Amaravadi Ravi K. , Kwong Lawrence N. , Frederick Dennie T. , Boland Genevieve M. , Salvino Joseph M. , Speicher David W. , Flaherty Keith T. , Ronai Ze'ev A. , Herlyn Meenhard
Published: April 2023

Supplementary Table
Table S1 from Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance
Authors: Liu Jianglan , Rebecca Vito W. , Kossenkov Andrew V. , Connelly Thomas , Liu Qin , Gutierrez Alexis , Xiao Min , Li Ling , Zhang Gao , Samarkina Anastasia , Zayasbazan Delaine , Zhang Jie , Cheng Chaoran , Wei Zhi , Alicea Gretchen M. , Fukunaga-Kalabis Mizuho , Krepler Clemens , Aza-Blanc Pedro , Yang Chih-Cheng , Delvadia Bela , Tong Cynthia , Huang Ye , Delvadia Maya , Morias Alice S. , Sproesser Katrin , Brafford Patricia , Wang Joshua X. , Beqiri Marilda , Somasundaram Rajasekharan , Vultur Adina , Hristova Denitsa M. , Wu Lawrence W. , Lu Yiling , Mills Gordon B. , Xu Wei , Karakousis Giorgos C. , Xu Xiaowei , Schuchter Lynn M. , Mitchell Tara C. , Amaravadi Ravi K. , Kwong Lawrence N. , Frederick Dennie T. , Boland Genevieve M. , Salvino Joseph M. , Speicher David W. , Flaherty Keith T. , Ronai Ze'ev A. , Herlyn Meenhard
Published: April 2023

Supplementary Table
Data from SOX4 Induces Epithelial–Mesenchymal Transition and Contributes to Breast Cancer Progression
Authors: Zhang Jianchao , Liang Qian , Lei Yang , Yao Min , Li Lili , Gao Xiaoge , Feng Jingxin , Zhang Yu , Gao Hongwen , Liu Dong-Xu , Lu Jun , Huang Baiqu
Published: April 2023

Abstract
Epithelial–mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and invasion, along with epithelial stem cell properties defined by the presence of a CD44high/CD24low cell subpopulation. SOX4 positively regulated expression of known EMT inducers, also activating the TGF-β pathway to contribute to EMT. SOX4 itself was induced by TGF-β in mammary epithelial cells and was required for TGF-β–induced EMT. Murine xenograft experiments showed that SOX4 cooperated with oncogenic Ras to promote tumorigenesis in vivo. Finally, in clinical specimens of human breast cancer, we found that SOX4 was abnormally overexpressed and correlated with the triple-negative breast cancer subtype (ER−/PR−/HER2−). Our findings define an important function for SOX4 in the progression of breast cancer by orchestrating EMT, and they implicate this gene product as a marker of poor prognosis in this disease. Cancer Res; 72(17); 4597–608. ©2012 AACR.
Data from Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance
Authors: AlHossiny Midrar , Luo Linlin , Frazier William R. , Steiner Noriko , Gusev Yuriy , Kallakury Bhaskar , Glasgow Eric , Creswell Karen , Madhavan Subha , Kumar Rakesh , Upadhyay Geeta
Published: April 2023

Abstract
Stem cell antigen Sca-1 is implicated in murine cancer stem cell biology and breast cancer models, but the role of its human homologs Ly6K and Ly6E in breast cancer are not established. Here we report increased expression of Ly6K/E in human breast cancer specimens correlates with poor overall survival, with an additional specific role for Ly6E in poor therapeutic outcomes. Increased expression of Ly6K/E also correlated with increased expression of the immune checkpoint molecules PDL1 and CTLA4, increased tumor-infiltrating T regulatory cells, and decreased natural killer (NK) cell activation. Mechanistically, Ly6K/E was required for TGFβ signaling and proliferation in breast cancer cells, where they contributed to phosphorylation of Smad1/5 and Smad2/3. Furthermore, Ly6K/E promoted cytokine-induced PDL1 expression and activation and binding of NK cells to cancer cells. Finally, we found that Ly6K/E promoted drug resistance and facilitated immune escape in this setting. Overall, our results establish a pivotal role for a Ly6K/E signaling axis involving TGFβ in breast cancer pathophysiology and drug response, and highlight this signaling axis as a compelling realm for therapeutic invention. Cancer Res; 76(11); 3376–86. ©2016 AACR.