bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent advances in functional genomics for parasitic nematodes of mammals
Authors: Castelletto Michelle L. , Gang Spencer S. , Hallem Elissa A.
Published: February 2020

Human-parasitic nematodes infect over a quarter of the world's population and are a major cause of morbidity in low-resource settings. Currently available treatments have not been sufficient to eliminate infections in endemic areas, and drug resistance is an increasing concern, making new treatment options a priority. The development of new treatments requires an improved understanding of the basic biology of these nematodes. Specifically, a better understanding of parasitic nematode development, reproduction and behavior may yield novel drug targets or new opportunities for intervention such as repellents or traps. Until recently, our ability to study parasitic nematode biology was limited because few tools were available for their genetic manipulation. This is now changing as a result of recent advances in the large-scale sequencing of nematode genomes and the development of new techniques for their genetic manipulation. Notably, skin-penetrating gastrointestinal nematodes in the genus Strongyloides are now amenable to transgenesis, RNAi and CRISPR/Cas9-mediated targeted mutagenesis, positioning the Strongyloides species as model parasitic nematode systems. A number of other mammalian-parasitic nematodes, including the giant roundworm Ascaris suum and the tissue-dwelling filarial nematode Brugia malayi, are also now amenable to transgenesis and/or RNAi in some contexts. Using these tools, recent studies of Strongyloides species have already provided insight into the molecular pathways that control the developmental decision to form infective larvae and that drive the host-seeking behaviors of infective larvae. Ultimately, a mechanistic understanding of these processes could lead to the development of new avenues for nematode control.
Evolution, developmental expression and function of odorant receptors in insects
Authors: Yan Hua , Jafari Shadi , Pask Gregory , Zhou Xiaofan , Reinberg Danny , Desplan Claude
Published: February 2020

Animals rely on their chemosensory system to discriminate among a very large number of attractive or repulsive chemical cues in the environment, which is essential to respond with proper action. The olfactory sensory systems in insects share significant similarities with those of vertebrates, although they also exhibit dramatic differences, such as the molecular nature of the odorant receptors (ORs): insect ORs function as heteromeric ion channels with a common Orco subunit, unlike the G-protein-coupled olfactory receptors found in vertebrates. Remarkable progress has recently been made in understanding the evolution, development and function of insect odorant receptor neurons (ORNs). These studies have uncovered the diversity of olfactory sensory systems among insect species, including in eusocial insects that rely extensively on olfactory sensing of pheromones for social communication. However, further studies, notably functional analyses, are needed to improve our understanding of the origins of the Orco–OR system, the mechanisms of ORN fate determination, and the extraordinary diversity of behavioral responses to chemical cues.
How to turn an organism into a model organism in 10 ‘easy’ steps
Authors: Matthews Benjamin J. , Vosshall Leslie B.
Published: February 2020

Many of the major biological discoveries of the 20th century were made using just six species: Escherichia coli bacteria, Saccharomyces cerevisiae and Schizosaccharomyces pombe yeast, Caenorhabditis elegans nematodes, Drosophila melanogaster flies and Mus musculus mice. Our molecular understanding of the cell division cycle, embryonic development, biological clocks and metabolism were all obtained through genetic analysis using these species. Yet the ‘big 6’ did not start out as genetic model organisms (hereafter ‘model organisms’), so how did they mature into such powerful systems? First, these model organisms are abundant human commensals: they are the bacteria in our gut, the yeast in our beer and bread, the nematodes in our compost pile, the flies in our kitchen and the mice in our walls. Because of this, they are cheaply, easily and rapidly bred in the laboratory and in addition were amenable to genetic analysis. How and why should we add additional species to this roster? We argue that specialist species will reveal new secrets in important areas of biology and that with modern technological innovations like next-generation sequencing and CRISPR-Cas9 genome editing, the time is ripe to move beyond the big 6. In this review, we chart a 10-step path to this goal, using our own experience with the Aedes aegypti mosquito, which we built into a model organism for neurobiology in one decade. Insights into the biology of this deadly disease vector require that we work with the mosquito itself rather than modeling its biology in another species.
Gas System for the ATLAS NSW Micromegas Detectors: Design Aspects and Advanced Validation Methods for their QA/QC
Authors: Alexopoulos T. , Gazis E. , Maltezos S. , Antoniou A. , Gika V. , Karentzos S. , Koulouris A. , Koutelieris G. , Moschovakos P.
Published: February 2020

In this work we present the design aspects of the Gas Distribution System of NSW Micromegas detectors, simulation results and gas flow / pressure uniformity. We also describe the appropriate gas leak test methods, a conventional and an alternative one, being used in the Quality Assurance and Quality Control of the detectors. For the performance studies we used emulated leak branches based on medical needles. We also describe proposed upgrade stages combining the proposed competitive Flow Rate Loss method with the Lock-in Amplifier technique. Further, we describe the baseline setup for the Gas Tightness Station at BB5/CERN.
Radiotherapy (RT) innovative Technology combined with Hospital/Home-Care Standards and Medical Protocols and Guidelines: A collective Compendium
Authors: Spyropoulos B. , Adamopoulou M. , Arbis S. , Bouboukiotis G. , Chatziavazis G. , Chatzigeorgioadis K. , Golfinopoulos K. , Golfinopoulou A. , Kalfas A. , Karatzetzos S. , Kavadas D. , Kefalidis E. , Kotsinonos G. , Koukoularis P. , Kyriazopoulos C. , Linardatos D. , Makri S. , Marinis M. , Monocholias K. , Roumeliotis S. , Stathopoulos I. , Stavridis K. , Stergiou T. , Tsantoulis M. , Tsitsigronis O.
Published: February 2020

A heuristic “3-dimensional” project is presented, accomplished by the 24 post-graduate students of our Department’s MSc. Course “Advanced Biomedical Technology”. The project has addressed, first, RT innovative Technology as reflected on Industrial Property (IP) docs, second, cardinal patient-care and medical-managerial aspects and finally, their combination with relevant Medical Protocols, Guidelines & Standards. Parts of the three modules of the 4th-trimester, i.e. “Large Therapeutic and Diagnostic Facilities Safety, Radiation Protection and Quality Assurance” (PMS_BIT_2.4.), “Biomedical Technology (BMT) of Home-Surveillance, Health-Care Management and Online Health Services” (PMS_BIT_2.5.) and “BMT-Quality Assurance, Industrial Property Rights, Technical Standards and Medical Protocols and Guidelines” (PMS_BIT_2.6.), taught by the first author, have been combined and each student has prepared and orally presented a “3-D” paper. Around 1000 pages of relevant content (over 1 GB) with numerous Figures and Tables are included in the produced Compendium. The quality of the students’ papers and presentations corroborate the need of introducing novel, contemporary and creative examination methods, attracting their interest and promoting their self-confidence.
Investigation of (n,2n) reactions using the high energy neutron facility at NCSR “Demokritos”
Authors: Vlastou R. , Kalamara A. , Kokkoris M. , Serris M. , Patronis N. , Diakaki M. , Spiliotis A. , Georgoulakis M. , Sigalos D. , Hassapoglou S. , Kobothanasis K. , Krokidi K. , Lagoyannis A. , Axiotis M. , Harrisopulos S.
Published: February 2020

In the high energy neutron facility at the 5.5MV tandem T11/25 Accelerator of NCSR "Demokritos", the neutron beam is produced by means of the 3H(d,n)4He reaction in the energy range ~15-21 MeV and at a flux of the order of 105 -106 n/cm2s. The beam has been characterized by means of the NeuSDesc and MCNP5 Monte Carlo simulations along with the multiple foil activation technique at various neutron energies. The neutron flux has been deduced using reference reactions, such as the 27Al(n,α) reaction, while the flux variation of the neutron beam was monitored by using a BF3 detector. After the characterization, the neutron beam has been used for (n,2n) reaction cross section measurements on Hf, Au and Ir isotopes via the activation technique. The irradiations were carried out at 15.3 and 17.1 MeV.
The 240Pu(n,f) cross section measurement at the new experimental area at CERN's n_TOF facility
Authors: Stamatopoulos A. , NTOF Collaboration For the
Published: February 2020

The accurate knowledge of the neutron-induced fission cross-sections of actinides and other isotopes involved in the nuclear fuel cycle are essential for the design of advanced nuclear systems. These experimental data can also provide feedback for the adjustment of nuclear model parameters used in the evaluation process, resulting in further developments of nuclear fission models. In the present work, the 240Pu(n,f) cross-section was measured at CERN's n_TOF facility over a wide range of neutron energies, from a few meV to several MeV, using the time-of-flight technique and a set-up based on MicroMegas detectors. This measurement was the first experiment to be performed in n_TOF's new experimental area (EAR-2), which offers a significantly higher neutron flux compared to the existing experimental area. Preliminary results as well as the experimental procedure, including a brief description of the facility, the sample mounting, the read-out process and the data handling and analysis, are presented.
Systematic cross section measurements of (α,γ) reactions for astrophysics
Authors: Provatas G. , Foteinou V. , Axiotis M. , Lagoyannis A. , Demetriou P. , Harissopulos S. , Becker H.-W. , Rogalla D. , Netterdon L. , Winkens J. , Zilges A.
Published: February 2020

N/A
Critical point for the Deformation Dependent Mass model through a variational procedure
Authors: Petrellis D.
Published: February 2020

The recently introduced Deformation-Dependent Mass model is combined with a variational approach to the Bohr Hamiltonian in order to describe transitional nuclei. The results of this procedure are demon- strated for the ‘spherical to γ-unstable’ and the ‘spherical to deformed’ transitional classes, which corre- spond to the E(5) and X(5) solutions.
High energy fission cross sections induced by deuteron on 232Th and proton on natPb targets
Authors: Zamani M. , Stoulos S. , Fragopoulou M. , Krivopustov M.
Published: February 2020

Total fission cross sections induced by deuterons with energies 1.6, 2.5 and 4.0 GeV on 232Th targets and by protons on natPb targets at energy 2.0 GeV were measured during irradiations at the Nuclotron accelerator, JINR, Dubna. Using Solid State Nuclear Track detectors, the fission cross sections induced by deuterons on 232Th were determined as 1277±216, 1232±207 and 1153±198 mb, corresponding to the energies mentioned above. The total fission cross section of protons on natPb was estimated by the same method as 131±30 mb. These results were compared to the previous systematic parameterization of proton induced fission and new values for the parameters of deuteron-induce fission on actinides, 232Th and 238U and proton induced fission on natPb were deduced. Fitting results obtained for deuterons on actinides are discussed and compared to results for protons.
Application of information theory in atoms, nuclei and atomic clusters
Authors: Panos C. P. , Massen S. E.
Published: February 2020

The position- and momentum-space information entropies of the electron distributions of atomic clusters are calculated using a Woods-Saxon single particle potential. The same entropies are also calculated for nuclear distributions according to the Skyrme parametrization of the nuclear mean field. It turns out that a similar functional form S = α + Μη Ν for the entropy as function of the number of particles Ν holds approximately for atoms, nuclei and atomic clusters. It is conjectured that this is a universal property of a many-fermion system in a mean field.
The 3-Dimensional g-Deformed Harmonic Oscillator and a Unified Description of Magic Numbers of Metal Clusters
Authors: Karoussos N. , Bonatsos Dennis , Raychev P. P. , Roussev R. P.
Published: February 2020

Magic numbers predicted by a 3-dimensional (/-deformed harmonic oscillator with u9(3) D soq(3) symmetry are compared to experimental data for atomic clusters of alkali metals (Li, Na, K, Rb, Cs), noble metals (Cu, Ag, Au), divalent metals (Zn, Cd), and trivalent metals (Al, In), as well as to theoretical predictions of jellium models, Woods-Saxon and wine bottle potentials, and to the classification scheme using the 3n + / pseudo quantum number. In alkali metal clusters and noble metal clusters the 3-dimensional çr-deformed harmonic oscillator correctly predicts all experimentally observed magic numbers up to 1500 (which is the expected limit of validity for theories based on the filling of electronic shells), while in addition it gives satisfactory results for the magic numbers of clusters of divalent metals and trivalent metals, thus indicating that ug(3), which is a nonlinear extension of the u(3) symmetry of the spherical (3-dimensional isotropic) harmonic oscillator, is a good candidate for being the symmetry of systems of several metal clusters.
Parafermionic mapping of the two-colour delta model of interacting quarks
Authors: Daskaloyannis C. , Bonatsos Dennis , Kanakoglou K.
Published: February 2020

Parafermions are used for creating an exact mapping of the two-colour delta model of interacting quarks, used in nuclear physics
Ανάπτυξη τομογραφικής γ-κάμερα υψηλής διακριτικής ικανότητας
Authors: Λούντος Γ. , Νικήτα Κ. , Ουζούνογλου Ν. , Γιοκαρης Ν. , Παπανικόλας Κ. , Στυλιαρης Ε. , Βαρβαρήγου Α. , Αρχιμανδρίτης Σ. , Μαϊντάς Δ. , Στεφανής Κ.
Published: February 2020

No abstract (available).
X-Ray Fluorescence Analysis of a Gold Ibex and other Artifacts from Akrotiri
Authors: Karydas A. G. , Pantazis T. , Doumas C. , Vlachopoulos A. , Nomikos P. , Thomson E. , Vecoli C. , Dinsmore M. , Zarkadas Ch.
Published: February 2020

In-situ X-ray fluorescence analysis (XRF) of ancient artifacts from the excavation area was performed using a novel X-ray instrumentation, composed of a portable silicon PIN thermoelectrically cooled X-ray detector, a miniature X-ray source, and portable data acquisition devices. The main objective of the analyses in Akrotiri was to explore the potential of the technique to provide answers to a wide range of archaeometric questions regarding the bulk composition of metal alloys, especially of gold, the characterization of corrosion products in bronze artifacts, identification of inorganic elements which are fingerprints of the minerals used in wall-painting pigments, and of the painting materials and techniques used for the decoration of clay vase surfaces. Among the analysed artifacts are a unique gold ibex, a bronze dagger and blade, various pigments from the wall paintings of room 3 in Xeste 3, decoration pigments from rosettes of faience, a bichrome jug, and other clay vases. The results of the in-situ XRF survey, primarily those of the bulk composition and soldering technology of the gold ibex, are discussed and compared with literature.
On the pH-dependent strontium adsorption by Al-PILCs, impregnated with carboxylate groups of various acid strengths
Authors: Papachristodoulou C. A. , Assimakopoulos P. A. , Gangas N-H. J.
Published: February 2020

The impregnation of a PILC with carboxylate groups is proposed as a means to improve the adsorption properties of the material for strontium ions. The role of solution pH and carboxylate acid strength in the functionalization of the organic groups is probed by base titrations. In comparing the pristine-PILC with PILCs carrying either oxalate or acetate impregnates, enhanced strontium uptake is evidenced by the modified solids, initiated at pH 6 and 8 in the presence of oxalate and acetate, respectively. The effect on uptake is higher in the former case, amounting to an increase in strontium adsorption by a factor between two and three, depending on the pH range. To further elucidate the significance of the carboxylate acid strength in cation uptake phenomena, strontium adsorption isotherms are presented for PILCs carrying acetate, oxalate, malonate and citrate groups. The results demonstrate that, at constant pH, adsorption increases with increasing acid strength
Μεταφορά των ραδιενεργών ισοτόπων 137Cs, 40Κ και 7Be από το έδαφος στους φυτικούς οργανισμούς
Authors: Ιωαννίδου Α. , Μανωλοπούλου Μ. , Στούλος Σ. , Γερασόπουλος Ε. , Παπαστεφάνου Κ.
Published: February 2020

No abstract (available).
Theoretical calculations for the reaction 241Am(n, 2n) in the framework of the Hauser-Feshbach model
Authors: Perdikakis G. , Papadopoulos C. T. , Kokkoris M. , Vlastou R.
Published: February 2020

The cross section of the reaction 2ilAm(n, 2n), has been measured by the activation method in the range from 9.6 to 11.4 MeV, at the Tandem accelerator facility of NCSR Demokritos. Statistical model calculations in the framework of the Hauser- Feshbach theory have been performed, and the first results are presented. Experimental data on the neutron induced fission cross section of 241Am, have been used as a constraint for the calculations. The results of the investigation are presented in comparison with experimental data and previous theoretical evaluations.
Decay properties of high spin states in Mn
Authors: Axiotis M. , Gadea A. , Märginean N. , Lenzi S. M. , Napoli D. R. , Ur C. A. , Martinez-Pinedo G. , Brandolini F. , De Angelis G. , Bazzacco D. , Borcea R. , Cameron J. A. , Cano-Ott D. , De Poli M. , Döring J. , Farnea E. , Grawe H. , Kalfas C. A. , Martinez T. , Mazzocchi C. , Nâcher Gonzalez E. , Roeckl E. , Rossi Alvarez C. , Rubio B. , Lunardi S. , Tain J. L. , Sanchez-Solano J.
Published: February 2020

The electromagnetic decay properties of high spin states in 52Mn have been studied through various experiments with the GASP and EUROBALL arrays plus the ISIS charged-particle detector, the Neutron-Wall and the Recoil Filter Detector. From 7-7-particles coincidence measurements, spins and parities of these states have been determined and using the Doppler-shift attenuation method the mean life of some of these states have been determined. These results are compared with large scale shell-model calculations in the full fp shell.
Information Entropy and Information Distances in Atoms, Nuclei and Bosonic Systems
Authors: Chatzisavvas K. Ch. , Moustakidis Ch. C. , Panos C. P.
Published: February 2020

The universal property for the information entropy S = a + h In Ζ is verified for atoms using a systematic study with Roothaan-Hartree-Fock (RHF) wave functions with atomic number Ζ — 2 — 54. The above relation was proposed previously for atoms, nuclei, atomic clusters and correlated atoms in a trap. Kullback-Leibler relative entropy Κ and Jensen-Shannon divergence J are employed to compare RHF with Thomas-Fermi (TF) density of atoms as well as another phenomenological density obtained by Sagar et al. Two-body density distributions in position- and momentum-space are used to calculate and compare the corresponding information entropies for correlated and uncorrelated nuclei and bosonic systems (correlated atoms in a trap). It is seen that short-range correlations (SRC) increase the values of S. One-body information entropy entropy S\ is compared with two-body information entropy and a conjecture is made for TV-body information entropy SN- The entropy Κ and the divergence J are also used to evaluate the information distance between correlated and uncorrelated densities both at the one- and the two-body levels for nuclei and trapped Bose gases.
Determination of Light Elements (Z<15) by PIGE Spectroscopy
Authors: Savidou A. , Paradellis T. , Aslanoglou X. , Pilakouta M.
Published: February 2020

No abstract (available).
Experimental Investigation of 137Cs aging in soil
Authors: Assimakopoulos P. A. , Ioannides K. G. , Karamanis D. T. , Pakou A. A. , Stamoulis K. C. , Vayanakis A. , Veltsos E.
Published: February 2020

No abstract (available).
New Directions in Nuclear Theory
Authors: Hodgson P. E.
Published: February 2020

No abstract (available).
Control System Implementation for the IASA Microtron
Authors: Barbarosou M. , Filippas T. A. , Gazis E. N. , Karabarbounis A. , Maroulis D. , Papanicolas C. N. , Patavalis N. , Rahmani H.
Published: February 2020

A progress report on the architectural design and implementation of the Control System for the Racetrack Microtron at the Institute of Accelerating Systems and Applications (IASA) in Athens, Greece is presented. The Control System for the IASA CW Microtron is being developed on the Experimental Physics and Industrial Control System (EPICS) environment. Since top priority for this project is the construction and commissioning of the Mcrotron's injector, emphasis is being given to the definition and refinement of the Control Architecture and its realization for the injector. The experience gained from the Control System at the injector will guide the further development of the Control System for the entire Microtron.
Study of the Irradiation Damage in Simple Crystals by Channeling
Authors: Kokkoris M. , Huber H. , Kossionides S. , Paradellis T. , Zarkadas Ch. , Gazis E. N. , Vlastou R. , Aslanoglou X. , Assmann W. , Karamian S.
Published: February 2020

Several experiments have been carried out in the past in order to examine the impact of medium and heavy ions in crystals in the MeV range, which is of particular interest in high energy implantations. In the present work, the gradual amorphisation of simple crystals such as Si (100), Ge (100) and W (100) when irradiated with 18 MeV 1 6 0 in a random direction is being studied using the progressive change of channeling parameters, up to a maximum dose of approximately 1Ί01 6 par tides/en*2. The results are compared to the ones present in literature and an attempt is made in order to explain the peculiarities of the experimental spectra.
Nuclear Techniques in the Characterisation of Pillared Layered Clays
Authors: Karamanis D. T. , Aslanoglou X. , Assimakopoulos P. A. , Gangas N. H. , Pakou A. A.
Published: February 2020

The methods of PIGE and XR.F were used to determine the variation of the elemental composition of an aluminum pillared montmorillonite during the material preparation while 7 spectroscopy was used to find the extent and the kinetics of caesium and strontium uptake from aqueous solutions
Detection of plated-out radon progenies on CR-39 detectors
Authors: Patiris D. L. , Ioannides K. G. , Tsabaris C.
Published: February 2020

A spectrometric study of alpha particles using CR-39 solid state nuclear track detectors is described. It is based on the application of software imposed selection criteria, concerning the geometrical and optical properties of the tracks which are created by alpha particles of specific energy falling on the detector at given angles of incidence. These selection criteria are based on a preliminary study of tracks’ parameters (major and minor axes and mean value of brightness), using the TRIAC II code. Since no linear relation was found between the energy and the geometric characteristics of the tracks (major and minor axes), we resorted to the use of an additional parameter in order to classify the tracks according to the particles’ energy. Since the brightness of tracks is associated with the tracks’ depth, the mean value of brightness was chosen as the third parameter. This method could be applied as a low cost technique in studies concerning the radon’s daughters 218Po and 214Po behavior in air.
СПЕЦИФИКА ЖЕНСКОЙ ПРЕСТУПНОСТИ В ТРАДИЦИОННОМ ОСЕТИНСКОМ ОБЩЕСТВЕ
Authors: Daueva Tamara Tamerlanovna
Published: February 2020

Цель. Актуальность тематики предопределена востребованностью исследований правовой культуры каждого народа, ее трансформациями и воздействием на современный этнический облик. Целью исследования является гендерный аспект системы уголовных наказаний осетин в дореформенный период на основании анализа правового положения женщины как субъекта преступления.Методы и методология проведения работы. Основным предлагаемым методологическим подходом является междисциплинарный, который включает методы, сложившиеся в этнологии и истории, с широким привлечением источникового и литературного материала, что позволяет реконструировать внутрисемейную правовую культуру, положение и статус женщины в осетинской семье. Применение принципа историзма призвано обеспечить анализ событий и явлений в контексте социально-экономического, административно-правового и культурного развития осетинского общества.Результаты. В исследуемый период осетинам была характерна патриархальная структура социума. В ней четко выделялась иерархия, разделялись полоролевые функции, из которых представление интересов семьи на уровне общества – мужская, а сфера активной деятельности женщин ограничивалась семейными заботами. Данный аспект сыграл важнейшую роль в специфике женских преступлений. Исследование адатов, которые имели целью разрешить конфликтную ситуацию, участником которого являлась женщина, привело к выводу, что обычное право не выделяло женщин в качестве субъекта преступления, совершенного за пределами семейно-родственного коллектива. Сделан вывод о неправоспособности женщины и правовом неравенстве в традиционном обществе осетин.Область применения результатов. Материалы исследования дают возможность углубленного изучения гендера в традиционном обществе, в частности, в правовой культуре. Результаты данного исследования могут быть использованы в образовательном процессе и научно-исследовательской деятельности.
ЛИНГВОКУЛЬТУРОЛОГИЧЕСКАЯ СПЕЦИФИКА ПОСЛОВИЦ С КОМПОНЕНТОМ-ЗООНИМОМ В АНГЛИЙСКОМ И РУССКОМ ЯЗЫКАХ
Authors: Bratashova Eleonora Viktorovna
Published: February 2020

Цель. В статье рассматриваются особенности пословиц с компонентом-зоонимом в английском и русском языках. Пословицы представляют собой неотъемлемую часть лингвокультурологического фундамента любого языка, которые репрезентируют историческую, культурную и языковую специфику жизни нации. Рассматриваемая форма народного творчества представляет собой жанр фольклора, иллюстрирующий особенности мышления народа, отражая его повседневный образ жизни, чем и обусловлен интерес к данной проблематике и определяется актуальность исследования. Автор работы рассматривает вариации определения пословиц в английской и русской литературе, анализирует их компоненты и выявляет частотность употребления пословиц с компонентом-зоонимом в английском и русском языках, анализирует специфические качества и свойства пословиц.Метод или методология проведения работы. В ходе исследования применяются такие методы как аксиологический, выявляющий специфику лингвокультуры в качестве структуры, объединяющей материальные и духовные ценности, системный метод для получения анализа взаимосвязи языка и культуры, метод сплошной выборки с целью получения практического материала исследования.Результаты. Основываясь на обширном материале теоретических исследовании и практических данных, авторы исследования приходят к выводу, что пословицы с компонентом-зоонимом представляют собой продуктивное явление в фольклористике как русского, так и английского языков, отражая его лингвокультурные свойства и черты. Изучив языковые и культурологические особенности пословиц, автор приходит к выводу, что в английском и русском языках, несмотря на географическую дистанцию, сохраняется семантическое соответствие многих пословиц.Область применения результатов. Результаты работы могут быть использованы в сфере межкультурной коммуникации, контактной лингвистики, языковой вариативности.
ЖАНРОВАЯ СПЕЦИФИКА АНТИУТОПИИ НА ПРИМЕРЕ РОМАНА В. ВОЙНОВИЧА «МОСКВА 2042»
Authors: Grekova Valeriia Vladimirovna
Published: February 2020

Цель. В статье выявляются черты жанра утопии и антиутопии. Фантастичность, как правило, лежит в основе сюжетов обеих. Обе тяготеют к фантастической условности, и утопические и антиутопические произведения обращаются к теме будущего. Время, к которому относится сюжет утопии и антиутопии, – это, как правило, далекое будущее, которое измеряется небольшими отрезками или веками. Пространство, как правило, ограничено: это или отдельный город, или остров, или любое другое закрытое место. Однако в ХХ веке жанр антиутопии изменился и развился по сравнению с классическими представлениями о нем. Статья посвящена пересмотру жанровой специфики романа В. Войновича «Москва 2042». Предметом анализа выступает роман «Москва 2042». Автор ставит целью раскрыть социально-философскую подоплеку романа.Метод проведения работы. В основе исследования находятся герменевтический, феноменологический и компаративистский методы, а также принцип историко-философской реконструкции.Результаты. В. Войнович оценивает свой роман «Москва 2042» как роман-предупреждение. Автором статьи были выявлены черты антиутопического романа, социально-философского для своего времени.Область применения результатов. Результаты исследования могут быть применены при дальнейшем изучении творчества В. Войновича, в образовательной, научной деятельности.
Korespondencja arcybiskupa ormiańskokatolickiego Józefa Teodorowicza z prymasem Polski kardynałem Augustem Hlondem z lat 1924-1938
Authors: Krzyżowski Tomasz
Published: February 2020

The Correspondence between the Armenian Catholic Archbishop Józef Teodorowicz and the Polish Primate Cardinal August Hlond in the years 1924-1938 Cardinal August Hlond (1881-1948) and Archbishop Józef Teodorowicz (1864-1938) are notable representatives of the Polish Episcopate of the first half of the 20th century. They were men of extraordinary abilities, spiritual and intellectual values and organizational skills. As devout shepherds and great patriots, they took an active part in public life. Their letters, which constitute the main subject of this edit, illustrate the comprehensive and multi-layered involvement of both hierarchs in the area of Church and state, as well as their intense mutual cooperation. The article raises a number of issues, mainly concerning the problems of the Catholic Church in Poland at that time, i.e. the establishment of the Catholic News Agency, the work to create the facilities of the Catholic Action and their activities, the Catholic press in Poland, religious ceremonies, the education reform, catechisation, religious congregations, and the work of the episcopacy: the agenda, pastoral letters, activities of individual committees, etc. In addition, the letters provide information on the position of the two hierarchs on the parliamentary elections and the political situation in Poland, and also on the dispute between Archbishop Teodorowicz and the Jesuit Paweł Siwek about the Catholic mystic Therese Neumann of Konnersreuth.
GRAPHIC DISCIPLINES AND DIGITAL PRODUCTION INTERDISCIPLINARY CONNECTIONS
Authors: Anamova R. R. , Ripetskiy A. V.
Published: February 2020

In the article it is considered a topical issue of identification and ordering graphic disciplines and digital production (additive) technologies interdisciplinary connections. It is proposed to include these interdisciplinary connections in the course work program content for graphic disciplines in the technical universities. A new analytical model of the educational process for graphic disciplines is developed. Based on this model interdisciplinary connections with digital production (additive) technologies knowledge area are formulated.
DEVELOPMENT OF METHODS FOR ASSESSING THE NATURAL FREQUENCY OF PERIODIC METAL CRYSTALLIZATION UNDER WELDING CONDITIONS
Authors: Morozov V. P. , Romanov Yu. G.
Published: February 2020

The method of estimation of the natural frequency of periodic crystallization of metal in welding conditions is presented. The frequency of crystallization is an objective reality caused by the release of latent heat at the interface (solid-liquid) surface. It is difficult to measure the frequency of latent heat release during welding, when the forces of its own electromagnetic field, the droplet transfer of the electrode metal, the wandering of the cathode spot, etc., act. Here you can add the action of alternating current in particular its strength when passing through the zero value. The use of a heat source of constant power that does not create any other disturbing effects in the form of a tungsten arc of direct current, an electron or laser beam, a plasma arc and the heat of a gas-welding flame without filler metal, made it possible to avoid the above disadvantages.It was suggested that the isotherms of crystallization on the surface of the joint may be followed by temporary cessation of crystallization on the basis of microstructure analysis. The presented method made it possible to determine the frequencies of natural temperature fluctuations on the interfacial surface depending on the welding speed, the chemical composition of the alloy using experimental examples.
DEVICES AND MEANS OF CONTROL OF UNDERGROUND FACILITIES BASED ON PLC TECHNOLOGY
Authors: Tebuev M.-B. I. , Tebuev T.-B. I. , Shpenst V. A.
Published: February 2020

The article presents a solution for data transmission via electrotechnical communication lines, based on the testing of capacitive and inductive connection devices. The article contains information about modern systems for monitoring and control of technological equipment in the mine, for communication, alarm, monitoring and alerts. The principles and features of the Power Line Communications system are described. The relevance of the introduction of PLC technology in the control system of hard structures is described.
Current Concepts in Brain Tumor Imaging
Authors: Norden Andrew D. , Pope Whitney B. , Chang Susan M.
Published: February 2020

Overview:

Magnetic resonance imaging (MRI) is the most useful imaging tool in the evaluation of patients with brain tumors. Most information is supplied by standard anatomic images that were developed in the 1980s and 1990s. More recently, functional imaging including diffusion and perfusion MRI has been investigated as a way to generate predictive and prognostic biomarkers for high-grade glioma evaluation, but additional research is needed to establish the added benefits of these indices to standard MRI. Response critieria for high-grade gliomas have recently been updated by the Response Assessment in Neuro-Oncology (RANO) working group. The new criteria account for nonenhancing tumor in addition to the contrast-enhancing abnormalities on which older criteria relied. This issue has recently come to the fore with the introduction of the antiangiogenic agent bevacizumab into standard treatment for recurrent glioblastoma. Because of its potent antipermeability effect, contrast enhancement is markedly reduced in patients who receive bevacizumab. The RANO criteria also address the phenomenon of pseudoprogression, in which there may be transient MRI worsening of a glioblastoma following concurrent radiotherapy and temozolomide.
Reducing the Cost of Cancer Care: How to Bend the Curve Downward
Authors: Smith Thomas J. , Hillner Bruce E. , Kelly Ronan J.
Published: February 2020

Overview:

Health care and cancer care costs are rising unsustainably such that insurance costs have doubled in 10 years. Oncologists find themselves both victims of high costs and the cause of high-cost care by what we do and what we do not do. We previously outlined five ways that oncologists could personally bend the cost curve downward and five societal attitudes that would require change to lower costs. Here, we present some practical ways to reduce costs while maintaining or improving quality, including: 1) evidence-based surveillance after curative therapy; 2) reduced use of white cell stimulating factors (filgrastim and pegfilgrastim); 3) better integration of palliative care into usual oncology care; and 4) use of evidence-based, cost-conscious clinical pathways that allow appropriate care and lead to equal or better outcomes at one-third lower cost.
Antiemetic Use in Oncology: Updated Guideline Recommendations from ASCO
Authors: Basch Ethan , Prestrud Ann Alexis , Hesketh Paul J. , Kris Mark G. , Somerfield Mark R. , Lyman Gary H.
Published: February 2020

Overview:

In 2011, ASCO updated its guideline for the use of antiemetics in oncology, informed by a systematic review of the medical literature. This is an abbreviated version of that guideline, which is available in full at www.asco.org/guidelines/antiemetics . Key changes from the prior update in 2006 include the following: Combined anthracycline and cyclophosphamide regimens were reclassified as highly emetic. Patients who receive this combination or any highly emetic agents should receive a 5-HT3 receptor antagonist, dexamethasone, and an NK1 receptor antagonist. A large trial validated the equivalency of fosaprepitant, a single-day intravenous formulation, with aprepitant; either therapy is appropriate. Preferential use of palonosetron is recommended for moderate emetic risk regimens, combined with dexamethasone. For low-risk agents, patients can be offered dexamethasone before the first dose of chemotherapy. Patients undergoing high emetic risk radiation therapy should receive a 5-HT3 receptor antagonist before each fraction and for 24 hours following treatment and may receive a 5-day course of dexamethasone during fractions 1 to 5. Continued symptom monitoring throughout therapy is recommended. Clinicians often underestimate the incidence of nausea, which is not as well controlled as vomiting. Detailed information about the development of the guideline as well as practice tools are available at www.asco.org/guidelines/antiemetics .
The Oncologist as the Patient with Cancer or Relative
Authors: Gilewski Teresa , Raber Martin , Sledge George W.
Published: February 2020

Overview:

To an extent, physicians are familiar with the consequences of illness through their interactions with patients. However, when cancer becomes personal, the physician has an opportunity to gain greater insight into the intricacies of medical care, including its humanistic elements. Physicians who encounter cancer in themselves or in a relative may deepen their understanding of the patient experience. Their views provide a unique perspective, on the basis of the convergence of their medical knowledge and personal reaction to illness. They also confront distinct challenges specific to their work environment. An enhanced recognition of their viewpoints provides valuable information in the quest to alleviate patient suffering and explore the fundamentals of patient care.
Recent Advances in Cardiotoxicity of Anticancer Therapies
Authors: Ryberg Marianne
Published: February 2020

Overview:

The treatment of two major diseases in the Western world, cancer and heart disease, has improved significantly in recent years. Today, many more cancers are curable than in previous years. Cancer treatment often consists of chemotherapy, radiation therapy, and now also targeted therapy. All three types of treatment can lead to an increased risk of developing or of worsening a pre-existent cardiovascular disease either during the treatment, immediately afterward, or several years after cessation of therapy. Anthracyclines, a class of drugs that are also known as anthracycline antibiotics, and the drug cisplatin have contributed to the success of cancer treatment. However, these agents can cause cardiovascular disease during treatment, and studies have shown that the risk of disease persists for many years after treatment stops. Irradiation contributes significantly to this risk when the cardiovascular system is part of the radiation field. If the targeted therapy also inhibits the genes responsible for maintaining the function of the cardiovascular system, development of cardiovascular symptoms is inevitable. Therefore, it is essential to have a cardiovascular endpoint in trials with targeted therapy. When treatment stops, however, the effect on the cardiovascular system appears to cease, but it is not known whether the long-term risk of developing cardiovascular disease increases. Combined, these factors indicate that close cooperation between oncologists and cardiologists is essential to optimally benefit patients with cancer.
Practical Management of Immune-Related Adverse Events from Immune Checkpoint Protein Antibodies for the Oncologist
Authors: Weber Jeffrey S.
Published: February 2020

Overview:

Monoclonal antibodies directed against immune checkpoint proteins, such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) or programmed death-1 (PD-1), can boost endogenous immune responses directed against tumor cells. Recently, ipilimumab was approved by the U.S. Food and Drug Administration (FDA) for the treatment of metastatic melanoma, and the anti-PD-1 antibody BMS-936558 has shown promising results in patients with melanoma, non-small cell lung cancer, and renal cell cancer. During treatment with these antibodies, a unique set of toxicities occur called immune-related adverse events (irAEs). These irAEs may occur at any time during treatment and include colitis characterized by a mild to moderate but occasionally severe and persistent diarrhea. Hypophysitis, hepatitis, pancreatitis, iridocyclitis, lymphadenopathy, neuropathies, and nephritis have also been reported with ipilimumab, and a subset of those side effects has also been observed with BMS-936558. Patient and physician education as well as good patient–caretaker communication are keys to limiting the morbidity of irAEs. Early recognition of these irAEs and initiation of treatment are critical to reduce the risk of complications, since virtually all irAEs are reversible with the use of steroids and other immune suppressants. The onset of grade 3 to 4 irAEs correlated with treatment response in some ipilimumab studies. This article provides detailed description and recommendations for practicing oncologists to manage the common irAEs associated with antibodies against immune checkpoint blockade.
Individual Communications Against Poland Before the Human Rights Committee: a Review and Tentative Conclusions
Authors: Łasak Katarzyna
Published: February 2020

Poland has been a party to the International Covenant on Civil and Political Rights of 16 December 1966 for forty years, and has been recognizing the right of individuals to submit applications to the Human Rights Committee for 25 years. The total number of communications amounts to 11, and the results of the examination thereof encourage consideration of denouncing the Optional Protocol to the International Covenant on Civil and Political Rights of 16 December 1966.
TÜKETİCİ SATIN ALMA DAVRANIŞINA ETKİ EDEN YAŞAM TARZI FAKTÖRLERİ İLE OTOMOBİLLERİN HAZSAL VE FAYDACI ÖZELLİKLERİNİN TERCİHİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: ÇELİK Sabahattin
Published: February 2020

Bu çalışma; ürünlerin hazsal ve faydacı yapısını açıklamaya çalışmaktır. Yaşam tarzı, tüketici satın alma davranışına etki eden en önemli faktörlerden biridir. Tüketici tercihleri yaşam tarzlarına ve ürünlerin hazsal (hedonic) ve faydacı (utilitarian) özelliklerine göre yönlendirilmektedir. Hazsal ürünler daha çok deneyimsel tüketim haz ve eğlence sağlarlarken; faydacı ürünler temelde yararlı ve fonksiyonel ürünlerdir. Tüketicilerin otomobil markaları arasındaki tercihleri hazsal nitelikler kadar (örneğin, sportif dizayn, sağlamlık, konfor vs.) faydacı özelliklere de (örneğin, estetik olma, prestij sağlama vs.) yönelmektedir.
Çalışmada, konuyla ilgili literatürde yer alan çalışmalarda kullanılan ölçeklerden ve grup görüşmesi aracılığıyla elde edilen değişkenlerden yararlanılarak tüketici yaşam tarzlarına göre otomobillerin hazsal ve faydacı özelliklerinin tercihine yönelik bilgi ve bulgulara ulaşılmaya çalışılmıştır. Bu amaçla lüks sınıf otomobil kullanıcılarının otomobil özelliklerini değerlendirmeleriyle yaşam tarzları arasında bir ilişkinin olup olmadığını test etmek amacıyla korelasyon analizi, otomobil markasına göre otomobillerin hazsal ve faydacı özelliklerine verdikleri önem derecelerinde farklılık olup olmadığını test etmek amacıyla Artova analizi, otomobil markalarını birbirinden en iyi ayıran değişkenleri bulmak amacıyla da diskriminant analizi kullanılmıştır
SATIŞ ELEMANLARININ ÖRGÜTSEL BAĞLILIĞI VE ÖRGÜTSEL VATANDAŞLIK DAVRANIŞLARI ARASINDAKİ İLİŞKİNİN BELİRLENMESİNE YÖNELİK BİR ARAŞTIRMA
Authors: YOLAÇ Gökhan
Published: February 2020

Son yıllarda yönetim literatüründe üzerinde sıkça durulan örgütsel bağlılık ve örgütsel vatandaşlık kavramları işletmelerin yönetiminde önem kazanmaktadır. Bu önem nedeniyle günümüzde örgütsel bağlılık ve örgütsel vatandaşlık üzerine çok sayıda araştırma yapılmaktadır.Yapılan araştırmalar örgütlerin başarısı ve performansı üzerinde bu kavramların büyük ölçüde etkisi olduğunu ortaya koymuştur.Rekabetin . hızla arttığı günümüz pazarlarında işletmeler insan faktörünün değerini daha fazla anlamaya başlamışlardır. Bu nedenle yöneticiler, örgütsel bağlılık ve örgütsel vatandaşlık kavramları üzerinde önemle durmuşlardır. Çalışmada önce örgütsel bağlılık ve örgütsel vatandaşlık kavramları değişik boyutları ile ele alınmıştır. Sonra konu ile ilgili bir anket uygulamasıyla, satış elemanlarının örgütsel bağlılıkları ile örgütsel vatandaşlık davranışları araştırılmıştır. Çalışmada örgütsel bağlılık ve örgütsel vatandaşlık davranışını belirlemek amacıyla faktör analizi gerçekleştirilmiştir. Ayrıca satış elemanlarının örgütsel bağlılık ve örgütsel vatandaşlık davranışı arasındaki ilişkiyi belirlemek amacıyla regresyon analizi yapılmıştır. Sonuç olarak satış elemanlarının örgütsel bağlılığının örgütse vatandaşlıkları üzerinde olumlu etkisi olduğu belirlenmiştir.
YENİ TİP İŞLETMELER: GLOBAL DOĞAN İŞLETMELERİN OLUŞUM NEDENLERİ VE ÖZELLİKLERİ
Authors: URAL Tülin , KÜÇÜKASLAN Aslı
Published: February 2020

Bu çalışmanın amacı günümüzde hızla yayılmaya başlayan ve yeni bir tür olan “Global Doğan İşletmeler” i incelemektir. Çalışmada global doğan işletmelerin çeşitli ülkelerdeki varlığına ilişkin bulgular ve kuramsal temelde global doğan işletmelerin varlığını açıklayan yaklaşımlar ele alınmaktadır. Ayrıca, global doğan işletmelerin özellikleri, ortaya çıkmalarına neden olan içsel ve dışsal dinamikler, ve uluslararası faaliyetlerde performanslarını arttıran faktörler, yönelimleri ve stratejileri ortaya konulmaktadır. Çalışmanın sonunda uygulamacılar ve araştırmacılar için öneriler sunulmaktadır. Uygulamacılar açısından bazı öneriler; kurulduklarından itibaren global özgöriişe sahip olmak, uluslararası faaliyetler için kaynak ayırma isteğinde olmak, uluslararası deneyime sahip olmak, kişisel ve kurumsal ağları oluşturmak, niş pazarlara odaklanmak ve proaktif uluslararası stratejiler uygulamak yönündedir. Araştırmacılar açısından, global doğan işletmelerin varlığını açıklayan nedensel modellerin ortaya konulması ve bu işletmelerin gelişim sürecinin -zaman serisi analizleri ile- test edilmesi önerilmektedir.
DAVRANIŞÇI FİNANS: FİLDİŞİ KULELER SARSILIYOR
Authors: SÖZER ORAN Jale
Published: February 2020

Davranışçı finans, klasik ekonomi ve finans teorilerini sorgulayan bir alan olarak son otuz yılda, özellikle Profesör Kahneınan ’ın Nobel Ödiilii kazanan çalışmalarıyla popülerlik kazandı. Davranışçı finans, bireylerin finans kararlarında davranış ve psikoloji boyutunu inceler. Finans kararlan, hem kişisel, hem de kurumsal yatırını kararları veya kurumsal finans kararları olabilir.
Piyasada gözlenen anomaliler ve bireylerin irrasyonel kararları, son yıllarda çok sayıda araştırma yapılmasına neden oldu. Arbitraj imkanlarının sınırlı oluşu ve bilişsel psikoloji, davranışçı finansın temellerini oluşturur. Davranışçı finans, her ne kadar davranışçı ekonomi daha çok makroekonomik konulara eğilse bile onunla birçok ortak paydaya sahiptir. Bir literatür incelemesi otan bu çalışmanın temel amacı, konunun gündeme getirilmesi ve Türkçe’de davranış odaklı finans terminolojisinin geliştirilmesidir.