bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing Sika Deer Identification: Integrating CNN-Based Siamese Networks with SVM Classification
Authors: Sharma Sandhya , Timilsina Suresh , Gautam Bishnu Prasad , Watanabe Shinya , Kondo Satoshi , Sato Kazuhiko
Published: May 2024

Accurately identifying individual wildlife is critical to effective species management and conservation efforts. However, it becomes particularly challenging when distinctive features, such as spot shape and size, serve as primary discriminators, as in the case of Sika deer. To address this challenge, we employed four different Convolutional Neural Network (CNN) base models (EfficientNetB7, VGG19, ResNet152, Inception_v3) within a Siamese Network Architecture that used triplet loss functions for the identification and re-identification of Sika deer. Subsequently, we then determined the best-performing model based on its ability to capture discriminative features. From this model, we extracted embeddings representing the learned features. We then applied a Support Vector Machine (SVM) to these embeddings to classify individual Sika deer. We analyzed 5169 image datasets consisting of images of seven individual Sika deers captured with three camera traps deployed on farmland in Hokkaido, Japan, for over 60 days. During our analysis, ResNet152 performed exceptionally well, achieving a training accuracy of 0.97, and a validation accuracy of 0.96, with mAP scores for the training and validation datasets of 0.97 and 0.96, respectively. We extracted 128 dimensional embeddings of ResNet152 and performed Principal Component Analysis (PCA) for dimensionality reduction. PCA1 and PCA2, which together accounted for over 80% of the variance collectively, were selected for subsequent SVM analysis. Utilizing the Radial Basis Function (RBF) kernel, which yielded a cross-validation score of 0.96, proved to be most suitable for our research. Hyperparameter optimization using the GridSearchCV library resulted in a gamma value of 10 and C value of 0.001. The OneVsRest SVM classifier achieved an impressive overall accuracy of 0.97 and 0.96, respectively, for the training and validation datasets. This study presents a precise model for identifying individual Sika deer using images and video frames, which can be replicated for other species with unique patterns, thereby assisting conservationists and researchers in effectively monitoring and protecting the species.
Dehaze-UNet: A Lightweight Network Based on UNet for Single-Image Dehazing
Authors: Zhou Hao , Chen Zekai , Li Qiao , Tao Tao
Published: May 2024

Numerous extant image dehazing methods based on learning improve performance by increasing the depth or width, the size of the convolution kernel, or using the Transformer structure. However, this will inevitably introduce many parameters and increase the computational overhead. Therefore, we propose a lightweight dehazing framework: Dehaze-UNet, which has excellent dehazing performance and very low computational overhead to be suitable for terminal deployment. To allow Dehaze-UNet to aggregate the features of haze, we design a LAYER module. This module mainly aggregates the haze features of different hazy images through the batch normalization layer, so that Dehaze-UNet can pay more attention to haze. Furthermore, we revisit the use of the physical model in the network. We design an ASMFUN module to operate the feature map of the network, allowing the network to better understand the generation and removal of haze and learn prior knowledge to improve the network’s generalization to real hazy scenes. Extensive experimental results indicate that the lightweight Dehaze-UNet outperforms state-of-the-art methods, especially for hazy images of real scenes.
Study of the Spatial Distribution of the Bark Beetle in the Ejido Tixtlancingo
Authors: Avila-Pérez Humberto , Guzmán-Martínez María , Rosas-Acevedo José L. , Navarro-Martínez José , Gallardo-Bernal Iván
Published: May 2024

The spatial distribution of Dendroctonus frontalis Zimmermann, 1868, and Dendroctonus mexicanus Hopkins, 1905, was determined from 2020 to 2021 in the Tixtlancingo ejido. The information came from two surveys because, despite the abundant forested areas in this geographical area of the state of Guerrero, Mexico, economic resources for pest biomonitoring are limited. However, it was possible to identify the presence of 76 outbreaks affecting 1117.697 hectares and 95,078 trees, totaling 14,223.8 m3 of standing timber volume. In 2020, 28 outbreaks were reported, with the eastern spatial distribution showing the most damage from bark beetles, particularly in outbreaks 7 and 14 of the surveyed area. The most affected conifers were Pinus maximinoi H. E. Moore (44.71%), Pinus oocarpa Schiede ex Schltdl. (39.93%), and Pinus pseudostrobus Lindl. (15.36%). The affected timber volume was observed in diameter categories of 30 cm for the three pine species, with infestation of 90,549 trees (13,497.6 m3 t.t.v. (total tree volume)) across 1057.64 hectares. In 2021, 48 outbreaks were recorded, with the northeastern and southern parts of the surveyed area showing the most damage from the bark beetle. The trees most affected by the bark beetle were P. oocarpa (59.17%), P. maximinoi (33.94%), and P. pseudostrobus (6.89%). It was observed that the affected volume occurred in trees with diameter categories of 50 cm for the three pine species, affecting 4529 trees (726.214 m3 t.t.v.) distributed over 60.06 hectares. The contribution of this work lies in establishing a baseline for monitoring damage caused by this beetle, which affects forest resources and diminishes the possibility of maintaining carbon capture areas in the medium and long term, thus impacting the Sustainable Development Goals (SDGs) of the 2030 agenda, specifically Goals 11, 13, and 15.
Utilizing Multi-Source Data and Cloud Computing Platform to Map Short-Rotation Eucalyptus Plantations Distribution and Stand Age in Hainan Island
Authors: Yin Xiong , Li Mingshi , Lai Hongyan , Kou Weili , Chen Yue , Chen Bangqian
Published: May 2024

Short-rotation eucalyptus plantations play a key positive role in the forestry economy due to their fast-growing and high-yielding properties. However, some studies have suggested that eucalyptus plantations introductions may have negative impacts on biodiversity and ecosystems’ stability. In order to precisely and promptly determine the influence of eucalyptus plantations on soil characteristics and hydrological processes, based on the rotation change rules of eucalyptus plantations, this study combined the continuous change detection and classification and spectral mixture analysis (CCDC-SMA) algorithm and the random forest (RF) algorithm to map the distribution and stand age of short-rotation eucalyptus plantations in Hainan Island. First, the forest distribution map was used to mask out the rubber plantations, and forest disturbances were extracted through the CCDC-SMA algorithm to determine the potential short-rotation eucalyptus plantations distribution. Second, using CCDC-SMA algorithm fitting coefficients, field surveys, original spectral bands, vegetation indices, and digital elevation models (DEM) as inputs to the RF algorithm, short-rotation eucalyptus plantations distribution maps were created and evaluated based on Google Earth images. Finally, the stand age of the newly mapped short-rotation eucalyptus plantations was estimated based on the breakpoints of the CCDC-SMA algorithm. The results showed that the producer, user, and overall accuracies of the 2022 short-rotation eucalyptus plantations map were estimated at 0.95, 0.95, and 0.94, respectively, and the validation R2 of the estimated stand ages was at 0.97. The eucalyptus plantations in Hainan Island had a total area of roughly 9.93 × 104 ha in 2022. Danzhou City had the highest planting area of eucalyptus plantations, followed by Changjiang County, Chengmai County, and Lingao County. It was worth noting that the eucalyptus plantations were mostly located in places with low altitudes (<200 m) and flat slopes (<10°). Approximately 43.91% of eucalyptus plantations were located in the three major watersheds. In addition, the 1-year-old eucalyptus plantations accounted for the highest areal percentage of 30.58%. These datasets are valuable tools to aid sustainable production, ecological assessment, and conservation of eucalyptus plantations.
Unraveling Forest Practice Policies in China: Subnational Comparisons through Policy Prescriptiveness Framework
Authors: Fu Yimin , Sun Yixian , Liu Jinlong , Cashore Benjamin William , Liang Wenyuan
Published: May 2024

Forest policy classification is critical to conducting comparisons and understanding performance variations across cases. Chinese-style forest policy has been in a black box to many outsiders, who tend to assume a decentralization policy model due to a great diversity of forest and socio-economic conditions in China. To test this hypothesis, we used the policy prescriptiveness framework to classify on-the-ground forest practice policies in central government and eight provinces, covering extensive territorial variations. We found that the eight subnational cases that implemented local policies appeared to be consistent with central policies, but there were also subtle differences within them. Our findings show that China utilized centralized and top-down policy models.
A Polygenic Risk Analysis for Identifying Ulcerative Colitis Patients with European Ancestry
Authors: Liu Ling , Wu Yiming , Li Yizhou , Li Menglong
Published: May 2024

The incidence of ulcerative colitis (UC) has increased globally. As a complex disease, the genetic predisposition for UC could be estimated by the polygenic risk score (PRS), which aggregates the effects of a large number of genetic variants in a single quantity and shows promise in identifying individuals at higher lifetime risk of UC. Here, based on a cohort of 2869 UC cases and 2900 controls with genotype array datasets, we used PRSice-2 to calculate PRS, and systematically analyzed factors that could affect the power of PRS, including GWAS summary statistics, population stratification, and impact of variants. After leveraging a stepwise condition analysis, we eventually established the best PRS model, achieving an AUC of 0.713. Meanwhile, samples in the top 20% of the PRS distribution had a risk of UC more than ten times higher than samples in the lowest 20% (OR = 10.435, 95% CI 8.571–12.703). Our analyses demonstrated that including population-enriched, more disease-associated SNPs and using GWAS summary statistics from similar ethnic background can improve the power of PRS. Strictly following the principle of focusing on one population in all aspects of generating PRS can be a cost-effective way to apply genotype-array-derived PRS to practical risk estimation.
Functional and Molecular Characterization of New SPTLC1 Missense Variants in Patients with Hereditary Sensory and Autonomic Neuropathy Type 1 (HSAN1)
Authors: Rochat Julie , Blavier André , Ruet Séverine , Vasseur Sophie , Puma Angela , Desnous Béatrice , Chan Victor , Delmont Emilien , Attarian Shahram , Juntas Morales Raul , Quadrio Isabelle , Vidoni Léo , Bonello-Palot Nathalie , Cheillan David
Published: May 2024

Hereditary sensory and autonomic neuropathy type 1 is an autosomal dominant neuropathy caused by the SPTLC1 or SPTLC2 variants. These variants modify the preferred substrate of serine palmitoyl transferase, responsible for the first step of de novo sphingolipids synthesis, leading to accumulation of cytotoxic deoxysphingolipids. Diagnosis of HSAN1 is based on clinical symptoms, mainly progressive loss of distal sensory keep, and genetic analysis. Aim: Identifying new SPTLC1 or SPTLC2 “gain-of-function” variants raises the question as to their pathogenicity. This work focused on characterizing six new SPTLC1 variants using in silico prediction tools, new meta-scores, 3D modeling, and functional testing to establish their pathogenicity. Methods: Variants from six patients with HSAN1 were studied. In silico, CADD and REVEL scores and the 3D modeling software MITZLI were used to characterize the pathogenic effect of the variants. Functional tests based on plasma sphingolipids quantification (total deoxysphinganine, ceramides, and dihydroceramides) were performed by tandem mass spectrometry. Results: In silico predictors did not provide very contrasting results when functional tests discriminated the different variants according to their impact on deoxysphinganine level or canonical sphingolipids synthesis. Two SPTLC1 variants were newly described as pathogenic: SPTLC1 NM_006415.4:c.998A>G and NM_006415.4:c.1015G>A. Discussion: The combination of the different tools provides arguments to establish the pathogenicity of these new variants. When available, functional testing remains the best option to establish the in vivo impact of a variant. Moreover, the comprehension of metabolic dysregulation offers opportunities to develop new therapeutic strategies for these genetic disorders.
A Sweet Potato MYB Transcription Factor IbMYB330 Enhances Tolerance to Drought and Salt Stress in Transgenic Tobacco
Authors: Wang Chong , Lei Jian , Jin Xiaojie , Chai Shasha , Jiao Chunhai , Yang Xinsun , Wang Lianjun
Published: May 2024

MYB transcription factors (TFs) play vital roles in plant growth, development, and response to adversity. Although the MYB gene family has been studied in many plant species, there is still little known about the function of R2R3 MYB TFs in sweet potato in response to abiotic stresses. In this study, an R2R3 MYB gene, IbMYB330 was isolated from sweet potato (Ipomoea batatas). IbMYB330 was ectopically expressed in tobacco and the functional characterization was performed by overexpression in transgenic plants. The IbMYB330 protein has a 268 amino acid sequence and contains two highly conserved MYB domains. The molecular weight and isoelectric point of IbMYB330 are 29.24 kD and 9.12, respectively. The expression of IbMYB330 in sweet potato is tissue-specific, and levels in the root were significantly higher than that in the leaf and stem. It showed that the expression of IbMYB330 was strongly induced by PEG-6000, NaCl, and H2O2. Ectopic expression of IbMYB330 led to increased transcript levels of stress-related genes such as SOD, POD, APX, and P5CS. Moreover, compared to the wild-type (WT), transgenic tobacco overexpression of IbMYB330 enhanced the tolerance to drought and salt stress treatment as CAT activity, POD activity, proline content, and protein content in transgenic tobacco had increased, while MDA content had decreased. Taken together, our study demonstrated that IbMYB330 plays a role in enhancing the resistance of sweet potato to stresses. These findings lay the groundwork for future research on the R2R3-MYB genes of sweet potato and indicates that IbMYB330 may be a candidate gene for improving abiotic stress tolerance in crops.
Integrating Fuzzy Cognitive Maps and the Delphi Method in the Conservation of Transhumance Heritage: The Case of Andorra
Authors: Segura Lluís , Ortiz Rocío , Becerra Javier , Ortiz Pilar
Published: May 2024

Transhumance and its associated heritage are extremely complex and dynamic systems, and their conservation requires the analysis of interdisciplinary factors. To this end, fuzzy cognitive maps (FCMs) and Delphi surveys were applied for the first time in the field of heritage conservation. The model was applied to the tangible and intangible transhumance heritage of Andorra to determine its current state of conservation and to evaluate strategies for its preservation. Two panels of experts worked on the development of the model. Five experts with profiles related to conservation and transhumance heritage formed the first panel, which designed the preliminary FCMs, while seven experts in Andorran cultural heritage (panel 2) adapted the preliminary FCM model to Andorran transhumance heritage using Delphi surveys. The FCM model allowed us to analyze the influence of different variables on the conservation of transhumance heritage and to assess policy decisions. Further studies will focus on the implementation of this model in other countries to establish common recommendations for the conservation of the cultural heritage of transhumance.
High Transferability of Neutralizing Antibodies against SARS-CoV-2 to Umbilical Cord Blood in Pregnant Women Vaccinated with BNT162b2 XBB.1.5: A Retrospective Cohort Study
Authors: Hayashi Takuma , Sano Kenji , Konishi Ikuo
Published: May 2024

Background: Coronavirus disease 2019 (COVID-19) can lead to severe respiratory illness, rapid disease progression, and higher rates of intensive care unit admission in pregnant women. Infection during pregnancy is associated with an increased risk of preterm delivery, cesarean section, fetal dysfunction, preeclampsia, and perinatal death. Vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from pregnant women to their fetuses has also been observed. Although severe infections in neonates and infants are rare, newborns can experience serious consequences from COVID-19 due to their suboptimal humoral immune system protection. The amino acids in the structural proteins of SARS-CoV-2 are constantly mutating. Since around January 2023, COVID-19, caused by omicron-type SARS-CoV-2 variants, has been prevalent globally. These variants can evade the immune response triggered by traditional mRNA-based COVID-19 vaccines, such as BNT162b2. Therefore, vaccination with BNT162b2 XBB.1.5, which provides protection against omicron-type SARS-CoV-2 variants, is recommended. Methods: This retrospective cohort study included 148 pregnant women who received the BNT162b2 XBB.1.5 vaccine at 30 partner medical institutions from September 2023 to January 2024. We examined the titers of anti-spike glycoprotein SARS-CoV-2 immunoglobin G (IgG) and IgA in the blood and umbilical cord blood obtained from the participants using ELISA. Findings: Anti-spike glycoprotein SARS-CoV-2 IgG and IgA titers were highest in the blood and cord blood at late gestational age (28–34 weeks). No serious side effects or adverse events were observed in either the pregnant women or their newborns. Interpretation: Pregnant women who received the BNT162b2 XBB.1.5 vaccine during gestational weeks 28 to 34 had the highest titers of anti-omicron SARS-CoV-2 variant antibodies in their blood. Moreover, these antibodies were transferred to their umbilical cord blood. To validate our findings, large cohort clinical studies involving numerous pregnant women are warranted. Funding: This study was funded by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS) and Grants-in-Aid for Medical Research from the Japan Agency for Medical Research and Development (AMED).
Molecular Surveillance of Artemisinin-Resistant Plasmodium falciparum Parasites in Mining Areas of the Roraima Indigenous Territory in Brazil
Authors: de Aguiar-Barros Jacqueline , Granja Fabiana , de Abreu-Fernandes Rebecca , de Queiroz Lucas Tavares , da Silva e Silva Daniel , Citó Arthur Camurça , Mocelin Natália Ketrin Almeida-de-Oliveira , Daniel-Ribeiro Cláudio Tadeu , Ferreira-da-Cruz Maria de Fátima
Published: May 2024

Multidrug- and artemisinin-resistant (ART-R) Plasmodium falciparum (Pf) parasites represent a challenge for malaria elimination worldwide. Molecular monitoring in the Kelch domain region (pfk13) gene allows tracking mutations in parasite resistance to artemisinin. The increase in illegal miners in the Roraima Yanomami indigenous land (YIL) could favor ART-R parasites. Thus, this study aimed to investigate ART-R in patients from illegal gold mining areas in the YIL of Roraima, Brazil. A questionnaire was conducted, and blood was collected from 48 patients diagnosed with P. falciparum or mixed malaria (Pf + P. vivax). The DNA was extracted and the pfk13 gene was amplified by PCR. The amplicons were subjected to DNA-Sanger-sequencing and the entire amplified fragment was analyzed. Among the patients, 96% (46) were from illegal mining areas of the YIL. All parasite samples carried the wild-type genotypes/ART-sensitive phenotypes. These data reinforce the continued use of artemisinin-based combination therapies (ACTs) in Roraima, as well as the maintenance of systematic monitoring for early detection of parasite populations resistant to ART, mainly in regions with an intense flow of individuals from mining areas, such as the YIL. This is especially true when the achievement of falciparum malaria elimination in Brazil is planned and expected by 2030.
A Comparison between Farm-Related Stress, Mental Health, and Social Support between Men and Women Farmers
Authors: Rudolphi Josie M. , Cuthbertson Courtney , Kaur Amandeep , Sarol Jesus
Published: May 2024

Agricultural producers have worse mental health than the general population; however, recent research has not considered differences in stressors and mental health conditions by gender. A survey was mailed to a random sample of farmers in Illinois to screen for symptoms of anxiety and depression and identify sources of stress and social support. Men experienced more stress related to environmental and economic conditions than women, while women tended to have slightly higher levels of geographic isolation stress than men. Overall, there were no significant differences by gender in the proportion meeting the criteria for depression or anxiety; however, the results are higher than what is observed in the general population. Among those farmers who experience higher levels of stress about geographic isolation, the odds for women farmers to experience depressive symptoms are four times more than men farmers (OR 4.46 (0.91, 21.8); p = 0.06). Additional research should examine the relationship between social support and mental health. Interventions to reduce stress by gender should be considered.
Role of Lipid-Lowering and Anti-Inflammatory Therapies on Plaque Stabilization
Authors: Bryniarski Krzysztof L. , den Dekker Wijnand , Legutko Jacek , Gasior Pawel , Tahon Jeroen , Diletti Roberto , Wilschut Jeroen M. , Nuis Rutger-Jan , Daemen Joost , Kleczynski Pawel , Van Mieghem Nicolas M. , Jang Ik-Kyung
Published: May 2024

Atherosclerosis is the predominant underlying etiopathology of coronary artery disease. Changes in plaque phenotype from stable to high risk may spur future major adverse cardiac events (MACE). Different pharmacological therapies have been implemented to mitigate this risk. Over the last two decades, intravascular imaging modalities have emerged in clinical studies to clarify how these therapies may affect the composition and burden of coronary plaques. Lipid-lowering agents, such as statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors, were shown not only to reduce low-density lipoprotein levels and MACE but also to directly affect features of coronary plaque vulnerability. Studies have demonstrated that lipid-lowering therapy reduces the percentage of atheroma volume and number of macrophages and increases fibrous cap thickness. Future studies should answer the question of whether pharmacological plaque stabilization may be sufficient to mitigate the risk of MACE for selected groups of patients with atherosclerotic coronary disease.
Lung Metastasectomy: Where Do We Stand? Results from an Italian Multicentric Prospective Database
Authors: Ambrogi Marcello Carlo , Aprile Vittorio , Sanna Stefano , Forti Parri Sergio Nicola , Rizzardi Giovanna , Fanucchi Olivia , Valentini Leonardo , Italiani Alberto , Morganti Riccardo , Cartia Carlotta Francesca , Hughes James M. , Lucchi Marco , Droghetti Andrea
Published: May 2024

Background/Objectives: The surgical resection of pulmonary metastases is considered a therapeutic option in selected cases. In light of this, we present the results from a national multicenter prospective registry of lung metastasectomy. Methods: This retrospective analysis involves data collected prospectively and consecutively in a national multicentric Italian database, including patients who underwent lung metastasectomy. The primary endpoints were the analysis of morbidity and overall survival (OS), with secondary endpoints focusing on the analysis of potential risk factors affecting both morbidity and OS. Results: A total 470 lung procedures were performed (4 pneumonectomies, 46 lobectomies/bilobectomies, 13 segmentectomies and 407 wedge resections) on 461 patients (258 men and 203 women, mean age of 63.1 years). The majority of patients had metastases from colorectal cancer (45.8%). In most cases (63.6%), patients had only one lung metastasis. A minimally invasive approach was chosen in 143 cases (30.4%). The mean operative time was 118 min, with no reported deaths. Morbidity most frequently consisted of prolonged air leaking and bleeding, but no re-intervention was required. Statistical analysis revealed that morbidity was significantly affected by operative time and pulmonary comorbidities, while OS was significantly affected by disease-free interval (DFI) > 24 months (p = 0.005), epithelial histology (p = 0.001) and colorectal histology (p = 0.004) during univariate analysis. No significant correlation was found between OS and age, gender, surgical approach, surgical extent, surgical device, the number of resected metastases, lesion diameter, the site of lesions and nodal involvement. Multivariate analysis of OS confirmed that only epithelial histology and DFI were risk-factors, with p-values of 0.041 and 0.031, respectively. Conclusions: Lung metastasectomy appears to be a safe procedure, with acceptable morbidity, even with a minimally invasive approach. However, it remains a local treatment of a systemic disease. Therefore, careful attention should be paid to selecting patients who could truly benefit from surgical intervention.
Long-Term Outcomes of Dental Rehabilitation and Quality of Life after Microvascular Alveolar Ridge Reconstruction in Patients with Head and Neck Cancer
Authors: Zeman-Kuhnert Katharina , Gaggl Alexander J. , Bottini Gian B. , Wittig Joern , Zimmermann Georg , Steiner Christoph , Lauth Wanda , Brandtner Christian
Published: May 2024

Background/Objectives: Dental rehabilitation after extended tumour resection and jaw reconstruction is challenging. The present study aimed to report the prosthetic outcome and quality of life (QoL) in patients with head and neck cancer (HNC) after microvascular alveolar ridge reconstruction. Methods: The prosthetic outcomes of all consecutive patients with HNC who underwent microvascular alveolar ridge reconstruction at the University Hospital Salzburg between 2011 and 2018 were investigated. Oral health-related QoL (OHrQoL) and overall QoL were assessed using the validated Oral Health Impact Profile-49 (OHIP-49) and Short Form-36 questionnaires. Results: During the study period, 115 consecutive patients with head and neck cancer underwent microvascular jaw reconstruction. Among them, 23.3% and 27.4% received conventional tissue-borne prostheses and implant-supported prostheses, respectively, while 48.7% did not undergo dental rehabilitation. The prosthetic outcome was not associated with tumour stage (p = 0.32). Oral health-related quality of life (OHrQoL) was best in patients with implant-supported dental rehabilitation (OHIP-49 median score = 7) and worst in those with conventional removable dentures (OHIP-49 median score = 54). The corresponding OHIP-49 median score for patients who could not undergo dental rehabilitation was 30.5. All Short Form-36 subscale scores were equal to or higher than the malignancy norm scores. Conclusions: After microvascular jaw reconstruction, approximately one-third of the HNC patients received adequate implant-supported dental rehabilitation. However, the risk of dental rehabilitation failure was 50%. The different prosthetic outcomes affected OHrQoL, but not overall QoL.
Prognostic Features of Sarcopenia in Older Hospitalized Patients: A 6-Month Follow-Up Study
Authors: Ferring Anne , Mück Luisa , Stegemann Jill , Wiebe Laura , Becker Ingrid , Benzing Thomas , Meyer Anna Maria , Polidori Maria Cristina
Published: May 2024

Background: Sarcopenia is associated with adverse health outcomes. Understanding the association between sarcopenia, multidimensional frailty, and prognosis is essential for improving patient care. The aim of this study was to assess the prevalence and prognostic signature of sarcopenia in an acute hospital setting co-led by internists and geriatricians. Methods: Sarcopenia was assessed by applying the European Working Group on Sarcopenia in Older People (EWGSOP2) algorithm, including the SARC-F score, handgrip strength, bioelectrical impedance analysis (BIA), and Timed Up and Go (TUG) test, to 97 older multimorbid inpatients (76.5 ± 6.8 years, 55% women). The patients underwent a Comprehensive Geriatric Assessment (CGA) including an evaluation of Geriatric Syndromes (GSs) and Resources (GR) and prognosis calculation using the CGA-based Multidimensional Prognostic Index (MPI), European Quality of life—5 Dimensions (EQ-5D-5L) scale, Rosenberg Self-Esteem Scale (RSES), and Geriatric Depression Scale (GDS). Information on survival and rehospitalizations was collected 1, 3, and 6 months after discharge. Results: Sarcopenia was present in 63% (95% CI: 54–72%) of patients and categorized as probable (31%), confirmed (13%), and severe sarcopenia (18%). Sarcopenic patients showed significantly higher median MPI-values (p < 0.001), more GSs (p = 0.033), fewer GR (p = 0.003), lower EQ-5D-5L scores (p < 0.001), and lower RSES scores (p = 0.025) than non-sarcopenic patients. Six months after discharge, being sarcopenic at baseline was predictive of falls (p = 0.027) and quality of life (p = 0.043), independent of age, gender, and MPI. Conclusions: Sarcopenia is highly prevalent in older hospitalized multimorbid patients and is associated with poorer prognosis, mood, and quality of life up to 6 months after discharge, independent of age, sex, and MPI as surrogate markers of biological age.
Early Postoperative Weight-Bearing Ability after Total Hip Arthroplasty versus Bipolar Hemiarthroplasty in Elderly Patients with Femoral Neck Fracture
Authors: Grabmann Chiara , Hussain Ibrahim , Zeller Anne , Kirnaz Sertac , Sullivan Vincent , Sommer Fabian
Published: May 2024

Background: Femoral neck fractures are among the most common types of fractures and particularly affect elderly patients. Two of the most common treatment strategies are total hip arthroplasty (THA) and bipolar hemiarthroplasty (BA). However, the role of the different treatment strategies in the postoperative weight-bearing ability in the early postoperative phase is still not entirely clear. Methods: Patients who underwent either THA or BA were consecutively included in our prospective cohort study. Gait analysis was performed during the early postoperative period. The gait analysis consisted of a walking distance of 40 m coupled with the turning movement in between. During the gait analysis, the duration of the measurement, the maximum peak force and the average peak force were recorded. Results: A total of 39 patients were included, 25 of whom underwent BA and 14 of whom underwent THA. The maximum peak force during the gait analysis was, on average, 80.6% ± 19.5 of the body weight in the BA group and 78.9% ± 21.6 in the THA group. The additionally determined average peak force during the entire gait analysis was 66.8% ± 15.8 of the body weight in the BA group and 60.5% ± 15.6 in the THA group. Conclusions: Patients with femoral neck fractures undergoing THA and BA can achieve sufficient weight bearing on the operated leg in the early postoperative period. In our study, BA did not allow for a significantly higher average and maximum loading capacity compared with THA.
Association between Metabolic-Dysfunction-Associated Steatotic Liver Disease and Hepatic Cancer: Current Concepts and Future Challenges
Authors: Bader Husam , Yamin Saif , Alshahwan Hamzeh , Farraj Husam , Maghnam Joud , Abu Omar Yazan Abu
Published: May 2024

Background: This study systematically reviewed the association between metabolic-dysfunction-associated steatotic liver disease (MASLD) and the development of hepatic cancer. Previous research has highlighted MASLD as a predisposing condition. Aim: To collect recent global data on the relationship between MASLD and hepatic cancer. Methods: A systematic review was conducted, which included an analysis of studies on the relationship between MASLD and the incidence of hepatic cancers, focusing on the role of fibrosis and MASLD severity as predictors of cancer risk. Following standard methodological frameworks for the assessment of longitudinal studies, the review gathered information on fibrosis scores, hepatocellular carcinoma (HCC) incidence, and other types of hepatic neoplasms. Results: A total of 522 studies were initially identified, of which 6 studies were appropriate for the review. They collectively revealed that the stage of fibrosis in MASLD is a significant independent predictor of mortality and liver-related events, with higher fibrosis stages correlating with greater risk. Longitudinal data showed that increases in FIB-4 scores were linked to a higher risk of developing HCC and cirrhosis. MASLD was also associated with an increased risk of non-hepatic cancers such as colorectal cancer in males and breast cancer in females. The severity of MASLD was found to be a modifiable risk factor for biliary tract cancer (BTC), with the risk further amplified by diabetes. Moreover, lifestyle factors and comorbidities, such as smoking and diabetes, were identified as modifiers of cancer risk in MASLD patients. Conclusions: The systematic review identified the association between MASLD and an elevated risk of hepatic cancer, establishing a clear link between the severity of liver fibrosis and the incidence of HCC and other hepatic neoplasms. This supports the need for screening for hepatic cancer in patients with MASLD, particularly in the presence of advanced fibrosis or other risk-modifying factors.
Wearable Sensors in Other Medical Domains with Application Potential for Orthopedic Trauma Surgery—A Narrative Review
Authors: Vogel Carolina , Grimm Bernd , Marmor Meir T. , Sivananthan Sureshan , Richter Peter H. , Yarboro Seth , Hanflik Andrew M. , Histing Tina , Braun Benedikt J.
Published: May 2024

The use of wearable technology is steadily increasing. In orthopedic trauma surgery, where the musculoskeletal system is directly affected, focus has been directed towards assessing aspects of physical functioning, activity behavior, and mobility/disability. This includes sensors and algorithms to monitor real-world walking speed, daily step counts, ground reaction forces, or range of motion. Several specific reviews have focused on this domain. In other medical fields, wearable sensors and algorithms to monitor digital biometrics have been used with a focus on domain-specific health aspects such as heart rate, sleep, blood oxygen saturation, or fall risk. This review explores the most common clinical and research use cases of wearable sensors in other medical domains and, from it, derives suggestions for the meaningful transfer and application in an orthopedic trauma context.
A Concert-Based Study on Melodic Contour Identification among Varied Hearing Profiles—A Preliminary Report
Authors: Paisa Razvan , Andersen Jesper , Ganis Francesco , Percy-Smith Lone M. , Serafin Stefania
Published: May 2024

Background: This study investigated how different hearing profiles influenced melodic contour identification (MCI) in a real-world concert setting with a live band including drums, bass, and a lead instrument. We aimed to determine the impact of various auditory assistive technologies on music perception in an ecologically valid environment. Methods: The study involved 43 participants with varying hearing capabilities: normal hearing, bilateral hearing aids, bimodal hearing, single-sided cochlear implants, and bilateral cochlear implants. Participants were exposed to melodies played on a piano or accordion, with and without an electric bass as a masker, accompanied by a basic drum rhythm. Bayesian logistic mixed-effects models were utilized to analyze the data. Results: The introduction of an electric bass as a masker did not significantly affect MCI performance for any hearing group when melodies were played on the piano, contrary to its effect on accordion melodies and previous studies. Greater challenges were observed with accordion melodies, especially when accompanied by an electric bass. Conclusions: MCI performance among hearing aid users was comparable to other hearing-impaired profiles, challenging the hypothesis that they would outperform cochlear implant users. A cohort of short melodies inspired by Western music styles was developed for future contour identification tasks.
Electrical Smoothing of the Powder Bed Surface in Laser-Based Powder Bed Fusion of Metals
Authors: Hofmann Andreas , Grotz Tim , Köstler Nico , Mahr Alexander , Döpper Frank
Published: May 2024

Achieving a homogeneous and uniform powder bed surface as well as a defined, uniform layer thickness is crucial for achieving reproducible component properties that meet requirements when powder bed fusion of metals with a laser beam. The existing recoating processes cause wear of the recoater blade due to protruded, melted obstacles, which affects the powder bed surface quality locally. Impairments to the powder bed surface quality have a negative effect on the resulting component properties such as surface quality and relative density. This can lead either to scrapped components or to additional work steps such as surface reworking. In this work, an electric smoother is presented with which a wear-free and contactless smoothing of the powder bed can be realized. The achievable powder bed surface quality was analyzed using optical profilometry. It was found that the electric smoother can compensate for impairments in the powder bed surface and achieve a reproducible surface quality of the powder bed regardless of the initial extent of the impairments. Consequently, the electric smoother offers a promising opportunity to reduce the scrap rate in PBF-LB/M and to increase component quality.
Digital versus Manual Tracing in Cephalometric Analysis: A Systematic Review and Meta-Analysis
Authors: Narkhede Sameer , Rao Paritosh , Sawant Veera , Sachdev Sanpreet Singh , Arora Suraj , Pawar Ajinkya M. , Reda Rodolfo , Testarelli Luca
Published: May 2024

Background: Over the years, various researchers have attempted to compare digital cephalometry with the conventional manual approach. There is a need to comprehensively analyze the findings from the earlier studies and determine the potential advantages and limitations of each method. The present systematic review aimed to compare the accuracy of digital and manual tracing in cephalometric analysis for the identification of skeletal and dental landmarks. Methods: A systematic search was performed using the keywords “Digital” AND “Manual” AND “Cephalometry” to identify relevant studies published in the English language in the past decade. The electronic data resources consulted for the elaborate search included the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, CINAHL, EMBASE, PsycINFO, Scopus, ERIC, and ScienceDirect with controlled vocabulary and free text terms. Results: A total of n = 20 studies were identified that fulfilled the inclusion and exclusion criteria within the timeframe of 2013 to 2023. The data extracted from the included articles and corresponding meta-analyses are presented in the text. Conclusions: The findings of the present systematic review and meta-analysis revealed trends suggesting that digital tracing may offer reliable measurements for specific cephalometric parameters efficiently and accurately. Orthodontists must consider the potential benefits of digital cephalometry, including time-saving and user-friendliness.
Deterioration in Quality of Life among COVID-19 Survivors: Population-Based Cohort Study
Authors: Oh Tak Kyu , Song In-Ae
Published: May 2024

We aimed to examine the prevalence of, and factors associated with, quality of life (QOL) worsening among coronavirus disease 2019 (COVID-19) survivors. This population-based retrospective cohort study used data from the Korea Disease Control and Prevention Agency and the National Health Insurance Service in South Korea. A total of 325,666 COVID-19 survivors were included in this study. Among them, 106,091 (32.6%) survivors experienced worsening QOL after COVID-19. Specifically, 21,223 (6.5%) participants experienced job loss, 94,556 (29.0%) experienced decreased household income, and 559 (0.2%) acquired new disabilities. In the multivariable logistic regression model, living in rural areas (odds ratio [OR]: 1.02; 95% confidence interval [CI]: 1.01, 1.04; p = 0.009), intensive care unit admission (OR: 1.08, 95% CI: 1.02, 1.15; p = 0.028), and increase in self-payment by 100 USD (OR: 1.02, 95% CI: 1.02, 1.02; p < 0.001) were associated with increased QOL worsening after COVID-19. Old age (OR: 0.99, 95% CI: 0.98, 0.99; p < 0.001), first vaccination (OR: 0.89, 95% CI: 0.86, 0.93; p < 0.001), and second vaccination (OR: 0.95, 95% CI: 0.93, 0.96; p < 0.001) were associated with decreased QOL worsening after COVID-19. Approximately one-third of COVID-19 survivors in South Korea who were admitted to hospitals or monitoring centers experienced QOL worsening.
Future Perspectives on Radiomics in Acute Liver Injury and Liver Trauma
Authors: Brunese Maria Chiara , Avella Pasquale , Cappuccio Micaela , Spiezia Salvatore , Pacella Giulia , Bianco Paolo , Greco Sara , Ricciardelli Luigi , Lucarelli Nicola Maria , Caiazzo Corrado , Vallone Gianfranco
Published: May 2024

Background: Acute liver injury occurs most frequently due to trauma, but it can also occur because of sepsis or drug-induced injury. This review aims to analyze artificial intelligence (AI)’s ability to detect and quantify liver injured areas in adults and pediatric patients. Methods: A literature analysis was performed on the PubMed Dataset. We selected original articles published from 2018 to 2023 and cohorts with ≥10 adults or pediatric patients. Results: Six studies counting 564 patients were collected, including 170 (30%) children and 394 adults. Four (66%) articles reported AI application after liver trauma, one (17%) after sepsis, and one (17%) due to chemotherapy. In five (83%) studies, Computed Tomography was performed, while in one (17%), FAST-UltraSound was performed. The studies reported a high diagnostic performance; in particular, three studies reported a specificity rate > 80%. Conclusions: Radiomics models seem reliable and applicable to clinical practice in patients affected by acute liver injury. Further studies are required to achieve larger validation cohorts.
Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome
Authors: Ndou Lutricia , Chambuso Ramadhani , Valley-Omar Ziyaad , Rebello George , Algar Ursula , Goldberg Paul , Boutall Adam , Ramesar Raj
Published: May 2024

Lynch syndrome (LS) is an inherited cancer predisposition disorder associated with an elevated risk of developing various solid cancers, but mostly colorectal cancer (CRC). Despite having the same germline pathogenic variant (PV) in one of the mis-match repair genes or the EPCAM gene, Lynch syndrome variant heterozygotes (LSVH) exhibit a remarkable phenotypic variability in the risk of developing cancer. The role of human leukocyte antigen (HLA) in modifying cancer development risk prompted our hypothesis into whether HLA variations act as potential genetic modifiers influencing the age at cancer diagnosis in LSVH. To investigate this, we studied a unique cohort of 426 LSVH carrying the same germline PV in the hMLH1 gene (MLH1:c.1528C > T) in South Africa. We intuitively selected 100 LSVH with the greatest diversity in age at cancer diagnosis (N = 80) and the oldest cancer unaffected LSVH (N = 20) for a high-throughput HLA genotyping of 11 HLA class I and class II loci using the shotgun next-generation sequencing (NGS) technique on the Illumina MiSeq platform. Statistical analyses employed Kaplan–Meier survival analyses with log-rank tests, and Cox proportional hazards using binned HLA data to minimize type I error. Significant associations were observed between young age at cancer diagnosis and HLA-DPB1*04:02 (mean age: 37 y (25–50); hazard ratio (HR) = 3.37; corrected p-value (q) = 0.043) as well as HLA-DPB1 binned alleles (including HLA-DPB1*09:01, HLA-DPB1*10:01, HLA-DPB1*106:01, HLA-DPB1*18:01, HLA-DPB1*20:01, HLA-DPB1*26:01, HLA-DPB1*28:01, HLA-DPB1*296:01, and HLA-DPB1*55:01) (mean age: 37 y (17–63); HR = 2.30, q = 0.045). The involvement of HLA-DPB1 alleles in the age at cancer diagnosis may highlight the potential role of HLA class II in the immune response against cancer development in LSVH. When validated in a larger cohort, these high-risk HLA-DPB1 alleles could be factored into cancer risk prediction models for personalized cancer screening in LSVH.
Diversification Is Not a Free Lunch
Authors: Baur Dirk G.
Published: May 2024

This study analyzed the statement “diversification is a free lunch”. We empirically showed that diversification is only a free lunch under uncertainty or ignorance, confirming Warren Buffett’s “diversification is protection against ignorance”. Using historical returns of the S&P500 constituents illustrated that diversification not only decreased the risk but also the returns if the expected returns could be estimated. The findings of this study highlight that diversification reduces risk but that the risk reduction is not for free.
Predictive Prognostic Factors in Non-Calcific Supraspinatus Tendinopathy Treated with Focused Extracorporeal Shock Wave Therapy: An Artificial Neural Network Approach
Authors: Santilli Gabriele , Vetrano Mario , Mangone Massimiliano , Agostini Francesco , Bernetti Andrea , Coraci Daniele , Paoloni Marco , de Sire Alessandro , Paolucci Teresa , Latini Eleonora , Santoboni Flavia , Nusca Sveva Maria , Vulpiani Maria Chiara
Published: May 2024

The supraspinatus tendon is one of the most involved tendons in the development of shoulder pain. Extracorporeal shockwave therapy (ESWT) has been recognized as a valid and safe treatment. Sometimes the symptoms cannot be relieved, or a relapse develops, affecting the patient’s quality of life. Therefore, a prediction protocol could be a powerful tool aiding our clinical decisions. An artificial neural network was run, in particular a multilayer perceptron model incorporating input information such as the VAS and Constant–Murley score, administered at T0 and at T1 after six months. It showed a model sensitivity of 80.7%, and the area under the ROC curve was 0.701, which demonstrates good discrimination. The aim of our study was to identify predictive factors for minimal clinically successful therapy (MCST), defined as a reduction of ≥40% in VAS score at T1 following ESWT for chronic non-calcific supraspinatus tendinopathy (SNCCT). From the male gender, we expect greater and more frequent clinical success. The more severe the patient’s initial condition, the greater the possibility that clinical success will decrease. The Constant and Murley score, Roles and Maudsley score, and VAS are not just evaluation tools to verify an improvement; they are also prognostic factors to be taken into consideration in the assessment of achieving clinical success. Due to the lower clinical improvement observed in older patients and those with worse clinical and functional scales, it would be preferable to also provide these patients with the possibility of combined treatments. The ANN predictive model is reasonable and accurate in studying the influence of prognostic factors and achieving clinical success in patients with chronic non-calcific tendinopathy of the supraspinatus treated with ESWT.