bluuebunny/crossref_metadata_2025 huggingface dataset:
Fluorescence-based thermometry for precise estimation of nanoparticle laser-induced heating in cancerous cells at nanoscale
Authors: Peltek Oleksii O. , Ageev Eduard I. , Talianov Pavel M. , Mikushina Anna D. , Epifanovskaya Olga S. , Dubavik Aliaksei , Veiko Vadim P. , Lepik Kirill , Zuev Dmitry A. , Timin Alexander S. , Zyuzin Mikhail V.
Published: August 2022

Photothermal therapy (PTT) has attracted increasing interest as a complementary method to be used alongside conventional therapies. Despite a great number of studies in this field, only a few have explored how temperatures affect the outcome of the PTT at nanoscale. In this work, we study the necrosis/apoptosis process of cancerous cells that occurs during PTT, using a combination of local laser heating and nanoscale fluorescence thermometry techniques. The temperature distribution within a whole cell was evaluated using fluorescence lifetime imaging microscopy during laser-induced hyperthermia. For this, gold nanorods were utilized as nanoheaters. The local near-infrared laser illumination produces a temperature gradient across the cells, which is precisely measured by nanoscale thermometry. This allows one to optimize the PTT conditions by varying concentration of gold nanorods associated with cells and laser power density. During the PTT procedure, such an approach enables an accurate determination of the percentages of apoptotic and necrotic cells using 2D and 3D models. According to the performed cell experiments, the influence of temperature increase during the PTT on cell death mechanisms has been verified and determined. Our investigations can improve the understanding of the PTT mechanisms and increase its therapeutic efficiency while avoiding any side effects.
Acrylamide; a neurotoxin in popcorns: a systematic review and meta-analysis
Authors: Abedini Amirhossein , Zirak Mohammad- Reza , Akbari Nader , Saatloo Naiema Vakili , Badeenezhad Ahmad , Sadighara Parisa
Published: August 2022

Acrylamide is a known neurotoxic compound for humans. Foods that have high concentrations of acrylamide need to be identified. One of the food products containing acrylamide is popcorn. Popcorn is an important source of snacks for children, especially students. The presented study is a systematic review and meta-analysis of the level of acrylamide in popcorn. The search was done in different databases with the keywords; acrylamide, popcorn, popped corn. 27 articles were found by searching various databases. After initial screening and full text evaluation, 8 articles were selected for systematic review and 6 articles for meta-analysis. The amount of acrylamide in this product was in the range of 1,017.7–106 μg/kg. Microwaved corn contains lower amounts of acrylamide than other methods of preparation. The type of popcorn also had an effect on the amount of acrylamide with Meta-regression. It was found that sweet popcorn contains higher amounts of acrylamide. The overall value of acrylamide concentration in popcorns was calculated to be 459.6 ± 220.3 μg/kg. This amount is high and requires measures to reduce the amount of acrylamide.
With or without a purpose? Judges’ appraisal of offenders or their behaviour in six sentencing remarks
Authors: Dai Xin
Published: August 2022

This study examines judges’ language use in sentencing remarks in the Crown Courts of England and Wales. Six sentencing remarks were selected from all those available on the UK judiciary website (by October 2016). The cases selected for closer analysis are as similar to each other as possible, so as to ensure that the differences in the discursive features of the sentencing remarks largely reflect the differences in judges’ sentencing practices. It is found that judges selectively use an appraisal strategy – using moralised purposes to invoke judgements of offenders or their behaviour – across the six sentencing remarks. Judges’ use (or non-use) of the appraisal strategy is found to be correlating with their sentencing decisions: i.e., judges opt for the appraisal strategy when their sentencing decisions are below or further above the starting point, but not when the decisions are just a few years above the starting point. The finding reveals that the statutory starting point exercises a binding effect on the judges’ sentencing practices despite the judges having the discretion to disregard the starting point. Such a finding not only provides an insight into the judges’ sentencing practices, but also demonstrates that appraisal analysis is an effective means to get access to sentencing, which seemed so inaccessible to academic research.
Numerical investigation of a variable stator vane with nonuniform partial radial gaps in an annular compressor cascade
Authors: Zhang Yimin , Chen Shaowen , Liu Yueqi , Wang Songtao
Published: August 2022

A variable stator vane (VSV) with nonuniform partial radial gaps is numerically investigated in an annular compressor cascade. Five adjusting angles (α = −5.5°, −5°, 0°, 5° and 10°) are chosen to simulate different working conditions. The VSV is adjusted in negative direction means that the stagger angle increases and the VSV is more closed. Since the VSV is installed in an annular cascade, the heights of the partial gaps are nonuniform and reaches 3.8% of the span. Results show that as the VSV is adjusted negatively, the total pressure loss rises by 20.3% and a huge area of corner separation appears. The outflow angle is also more distorted along radial direction. Comparisons with a fixed-configuration stator show that although the VSV would cause higher loss, it indeed plays an important role in adjusting the outflow angle.
Complex dynamical behaviour of predator–prey model with harvesting and multiple delays
Authors: Pal Amit K. , Mondal Ashok
Published: August 2022

In this work, we investigate a predator–prey model with Crowley–Martin functional response and constant harvesting. The model is extended by incorporating two constant time delays, where the first delay(τ
1) is for density dependent feedback mechanism in the logistic growth of the prey and the second one is for gestation delay(τ
2) of the predator population. The dynamical behaviours such as positivity, boundedness, extinction criteria and existence, stability and bifurcations of the equilibria of the non-delay model are qualitatively discussed. The existence of periodic solutions via Hopf-bifurcation with respect to absence of delay, single delay and both delays are established. Finally, numerical simulations have been carried out to confirm our numerical results.
Lineage Analysis ofCxcr4-Expressing Cells in the Developing Midbrain Suggests That Progressive Competence Restriction in Dopaminergic Progenitor Cells Contributes to the Establishment of Dopaminergic Neuronal Diversity
Authors: Petese Alessandro , Fries Franca L. , Broske Bianca , Stumm Ralf , Blaess Sandra
Published: August 2022

Midbrain dopaminergic (mDA) neurons are generated from a ventral midbrain progenitor zone over a time span of several days [embryonic day 10.0 (E10.0) to E14.5 in mouse]. Within this neurogenic period, a progressively changing fate potential of mDA progenitors could contribute to the generation of diverse mDA neuronal subpopulations. To test this idea, we combined inducible genetic fate mapping and intersectional labeling approaches to trace the lineage of cells expressing the chemokine receptor CXCR4. TheCxcr4transcript is expressed in mDA progenitors and precursors, but not in differentiated mDA neurons.Cxcr4-expressing mDA progenitors/precursors labeled at E11.5 develop into a broad range of mDA neurons, whereas labeling of theCxcr4lineage at later time points (E12.5–E15.5) results in an increasingly restricted contribution to mDA neurons proceeding from lateral to medial in the substantia nigra and from dorsal to ventral in the ventral tegmental area. In parallel, the innervation of dopaminergic projection targets by mDA neurons derived fromCxcr4-expressing cells is becoming more restricted: the late-generated mDA neurons innervate only the medial–rostral regions in the dorsal striatum and only the medial shell in the nucleus accumbens. Our results suggest that mDA progenitor cells become increasingly restricted in their cell fate potential over time.
Coordination between Eye Movement and Whisking in Head-Fixed Mice Navigating a Plus Maze
Authors: Bergmann Ronny , Sehara Keisuke , Dominiak Sina E. , Kremkow Jens , Larkum Matthew E. , Sachdev Robert N. S.
Published: August 2022

Navigation through complex environments requires motor planning, motor preparation, and the coordination between multiple sensory–motor modalities. For example, the stepping motion when we walk is coordinated with motion of the torso, arms, head, and eyes. In rodents, movement of the animal through the environment is coordinated with whisking. Even head-fixed mice navigating a plus maze position their whiskers asymmetrically with the bilateral asymmetry signifying the upcoming turn direction. Here we report that, in addition to moving their whiskers, on every trial mice also move their eyes conjugately in the direction of the upcoming turn. Not only do mice move their eyes, but they coordinate saccadic eye movement with the asymmetric positioning of the whiskers. Our analysis shows that asymmetric positioning of whiskers predicted the turn direction that mice will make at an earlier stage than eye movement. Consistent with these results, our observations also revealed that whisker asymmetry increases before saccadic eye movement. Importantly, this work shows that when rodents plan for active behavior, their motor plans can involve both eye and whisker movement. We conclude that, when mice are engaged in and moving through complex real-world environments, their behavioral state can be read out in the movement of both their whiskers and eyes.
Juárez y Zapata en el imaginario nacionalista mexicano
Authors: Álvarez Rebeca Villalobos
Published: August 2022

Este artículo compara la heroización póstuma de dos personajes históricos mexicanos: Benito Juárez y Emiliano Zapata. El objetivo principal es problematizar el vínculo entre idearios políticos y sensibilidades estéticas mediante el análisis de las cualidades de ambos héroes en la cultura nacionalista mexicana. Se revisa la presencia de estos personajes en el arte, los libros de texto y el discurso político para ponderar su importancia en la construcción del nacionalismo hegemónico, así como de algunas identidades periféricas. El estudio busca contribuir a un mejor entendimiento del nacionalismo mexicano del siglo XX desde la perspectiva de la historia cultural y los estudios sobre la memoria.
Modeling the Urban Commune
Authors: Fierro Alfonso
Published: August 2022

This article discusses a utopian architecture project presented by the Unión de Arquitectos Socialistas (UAS) in 1938 titled Proyecto de ciudad obrera para México DF. The UAS architects designed a city for industrial workers organized around cooperative principles and common property. The article situates the project in the period’s broader discussions on social housing and the industrializing political program of President Lázaro Cárdenas (1934–40). Drawing on social-reproduction theorists, I analyze the project’s political and architectural position, as well as the potentials and limits of its proposal to collectivize social-reproduction responsibilities that were normally placed on the family, such as cleaning, cooking, and childcare. Finally, the article charts the project’s later influence in social-housing debates and experiments in Mexico.
Machine-learning potentials for crystal defects
Authors: Freitas Rodrigo , Cao Yifan
Published: August 2022

Decades of advancements in strategies for the calculation of atomic interactions have culminated in a class of methods known as machine-learning interatomic potentials (MLIAPs). MLIAPs dramatically widen the spectrum of materials systems that can be simulated with high physical fidelity, including their microstructural evolution and kinetics. This framework, in conjunction with cross-scale simulations and in silico microscopy, is poised to bring a paradigm shift to the field of atomistic simulations of materials. In this prospective article we summarize recent progress in the application of MLIAPs to crystal defects.

Graphical abstract
Alternative Imaginations: Confronting and Challenging the Persistent Centrism in Social Media-Society Research
Authors: Lim Merlyna
Published: August 2022

This article attempts to intervene the current trend in social media research that, to a certain degree, reflects the centrality of technology. Beyond the broad trend of technocentrism, I identify and outline four other major oversights or challenges in researching the social media/society relationship, namely online data centrism, moment centrism, novelty centrism, and success centrism. Stemmed from these four types of centrism, I offer an alternative imagination, namely a set of alternative pathways in social media research that value histories and historical context, interdisciplinarity, longue durée, and complexity. By revealing these oversights, this article aims to contribute to our collective attempt to interrogate the relationship between social media and society (and technology/society) critically. This alternative imagination might help animate, reveal, and make transparent various societal dynamics that otherwise would be invisible and, thus, might contribute to a better, deeper, and more comprehensive understanding of the technology/society relationship.
The Question of India’s Endangered Democracy in the Light of Intolerance Debate: Some Reflections
Authors: Azad Abul Kalam
Published: August 2022

India is regarded as the world’s largest democratic country. The country is well known for its rich cultural diversity, pluralistic society and inclusive secular democracy. However, the recent political scenario has partially damaged the values of the liberal democracy of India. Since Narendra Modi became Prime Minister in 2014, the Bharatiya Janata Party (BJP) and its parental body Rashtriya Swayamsevak Sangha (RSS) have tried to accomplish their goal of Hindu Rashtra. Minorities in the country have been attacked, killed and deprived of their human rights. This article examines this trend by focusing on the growing intolerance during the Modi regime and its impact on the country’s democracy. It also discusses how the BJP at the central government and many other states, directly and indirectly, narrow down the space of civil society and media to fuel majoritarian agenda. Based on its findings, the article argues that in the Narendra Modi regime Indian political culture has been undergoing a shift from inclusive democracy to a narrow process of democracy. By doing so, it contributes to the studies on the rise of right-wing populism in some countries including India in the contemporary world.
Criteria for selection of educational material for the formation of future philologists’ Korean linguistic and socio-cultural competence in speaking
Authors: Asadchykh Oksana , Kindzhybala Oksana
Published: August 2022

As we can see, the modern processes of modernization of higher education cause particular importance for the formation of professionally-oriented communicative socio-cultural competence, the primary task of the institution is the formation of professional and communicative competence. Korean language didactics needs research, developing and testing of the new teaching methods, because the Korean language is typologically different from the Ukrainian language, the culture of nonverbal behavior of Koreans has no analogues in the world. The study raises issues of modern methods of teaching foreign languages, focuses on the relationship between language and culture, based on the formation of socio-cultural competence.
The article is devoted to the definition of the main criteria, for which the selection of didactic material for the teaching of Korean oral students can be developed, as well as the formation of Korean linguistic and socio-cultural competence in speaking. The concept of Korean-speaking linguistic and socio-cultural competence in conversations with future philologists is determined, its role and place in the university curriculum are analyzed. The analysis of structural-component conformity of competence is carried out, special attention is paid to the main tasks and stages of formation of linguistic and sociocultural competence in accordance with the level of students' language proficiency. The definition of the concept of culturally marked vocabulary in the Korean language is proposed. The procedure for selecting educational material is outlined. The selection of educational lexical material for the formation of Korean linguistic and socio-cultural competence in speaking on the basis of qualitative and quantitative indicators is done. The selection and the analysis of culturally marked lexical items, culturally marked monologues-samples and dialogues-samples are carried out. Methodical recommendations for the formation of Korean linguistic and socio-cultural competence in speaking are also given
Developing an automated system for collecting various information in the system of complex eco-energy-economic monitoring
Authors: Slipchenko Volodymyr , Poliahushko Liubov , Krush Olha
Published: August 2022

The study is devoted to the development of a system for the automated collection of primary information coming from different sources and in different formats. The object of the study is the properties of primary information and the processes that occur during its collection in systems of complex monitoring in various directions. One of the most problematic places is that information about the environmental, energy, economic and social state of the region can come from different sources and in different formats. This requires a significant investment of resources and time for the development of blocks in integrated monitoring systems.
In the course of the study, a systematic approach was used when analyzing the structure of sources and formats of information of various types, as well as an analysis method when developing a set of rules for collecting information.
The authors analyzed the structure of different sources and formats of primary information in the systems of environmental, energy, economic and medical monitoring. It has been determined that there is no single database and for conducting a comprehensive analysis it is necessary to collect data from various sources and in different formats, which requires a significant investment of resources and time. Therefore, in the course of the study, an automated system for collecting primary information was developed, which allows creating your own sets of rules for importing data from files of various formats. The proposed system can be integrated into large monitoring systems instead of an information collection unit. For example, the module for collecting primary information of the integrated eco-energy-economic monitoring system successfully uses the developed automated system to collect information that is necessary for analysis, modeling and forecasting of the territory by specialists of various profiles, namely: environmentalists, power engineers, economists and medical workers. This made it possible to reduce the total time for the development of a comprehensive eco-energy-economic monitoring system, as well as to increase the accuracy and timeliness of obtaining information during the operation of the monitoring system.
Research of methods for determining the accuracy of metrological measurements
Authors: Kozhevnikov Andrii , Bilous Nataliya
Published: August 2022

The object of research in this work are individual branches and processes of metrology, namely algorithms and methods of global positioning, analysis and research of individual processes, and their implementation in the software model to analyze their accuracy. The existing problem is that some methods or devices that produce results based on these methods are not accurate enough or their accuracy is affected by a number of factors that worsen the result.
During the work the methods and approaches of the global positioning system were analyzed, such as: precise point positioning, relative positioning of GPS, static and fast static GPS-shooting and Stop-and-go shooting. Approaches were also divided into static and kinematic. Among the methods, the method of precise point positioning was chosen, as the most common and used among ordinary GPS users, for more detailed research and analysis of accuracy. Development methods are based on the means of interaction with open GPS services, and C#, ASP.NET Core, Angular framework, and development environment Visual Studio Code and Visual Studio 2022.
In order to implement all the necessary functionality, the subject area was analyzed, the methods of determining metrological accuracy in general and within the system of global positioning as a direct object of work were considered. As a result of the work the analysis and modelling of the subject area was carried out, the methods of the global positioning system and the software system for the analysis of the accuracy of one of the GPS methods were investigated. The analysis results provided by the software help to understand the accuracy of the method and the GPS receivers that use it on different devices.
Development of methods of operative determination of parameters of repeated hydrate formation in layer systems of gas hydrate deposits
Authors: Pedchenko Nazar
Published: August 2022

The object of research is the methods of laboratory setting of the parameters of hydrate formation of well production and the design features of the equipment for its implementation. Methane hydrate is becoming a promising topic for a new energy resource. At the same time, hydrostatic formation is one of the most problematic areas in ensuring the transport of well products, and this primarily concerns the production of gas hydrate deposits. An analysis of the thermobaric parameters of the well production of gas hydrate deposits shows that when they are moved by technological lines, they are close to hydrate equilibrium, but due to the intensity of the process, the system does not have time to reach it. In addition, reservoir system water has a memory of hydrate structures, or a certain amount of gas hydrate solid phase is also present in the flow water. In this regard, a set of laboratory studies was carried out to assess the nature of the behavior of this type of systems during the re-crystallization of gas hydrate and its dissociation. Based on the results of the research, a method for the operational laboratory setting of the parameters of repeated hydrate formation in reservoir systems of gas hydrate deposits was developed. It provides for setting the parameters of mass crystallization of gas hydrate by visual fixation of the moment of appearance of the solid phase at the interfacial contact «liquid – gas». The design features of the laboratory facility for its implementation have also been developed and substantiated. The technique makes it possible to reduce the duration of the study of one sample by almost an order of magnitude (from several days to 8–10 hours). In addition to the information on the equilibrium parameters of hydrostatic formation, provided by traditional methods of laboratory research, an additional characteristic of the behavior of reservoir systems in non-equilibrium conditions has been obtained, which will help to quickly assess the risks of technogenic hydrate formation. The developed technique is important for systems that, at least, have a memory of hydrate structures. However, the preliminary transfer of a part of the water of the test sample through the gas hydrate form allows estimating the parameters of hydrate formation of any reservoir system.
Study on the effect of antioxidants on the quality and antioxidants capacity of duck sausages
Authors: Shang Feifei , Kryzhska Tetiana , Duan Zhenhua
Published: August 2022

Areca taro is a plant of the Araceae family, which is rich in starch and dietary fiber. Taro is boiled and mashed to make a paste, which is called taro paste. The fat content of duck sausages is high, and the nutritional composition of sausages can be improved by adding taro puree and provide the special aroma of taro in the sausages. Thus, the research object is duck sausage with taro paste.
This study aimed to improve the quality and prevent oxidation of duck sausage with taro paste by adding ginger juice, onion juice and sodium erythorbate as safe antioxidants. The quality characteristics of sausages were evaluated by analyzing the cooking loss, colour, texture and sensory changes, and the optimal amount of antioxidants was obtained by analyzing the acid value, TBARS value, and DPPH free radical scavenging rate.
The research results show that adding D-sodium erythorbate to duck sausage can significantly reduce the hardness of the sausage, maintain the elasticity of the sausage, and effectively slow down the pH value of the sausage during the oxidation process. The water retention and oil retention of duck sausage maintain the brightness value of the sausage. The sausage with D-sodium erythorbate has better antioxidant capacity. The acid value and TBARS value of the sausage added with D-sodium erythorbate at 18 h were significantly lower than those of the control group (P<0.05), and the DPPH was significantly increased.
This technology can provide data support and reference for food processing companies. The taro paste would be widely used as food ingredients in future.
Application of varieties of technogenic raw materials in cement technology
Authors: Dorogan Nataliia , Varshavets Petro , Chernyak Lev , Shnyruk Oleg
Published: August 2022

The possibility of manufacturing a mineral binder using large-tonnage waste from other industries has been studied. The object of the research are mixtures for the manufacture of cement clinker based on systems of chalk – clay – scope of paper production and chalk – clay – husks of rice processing. At the same time, urgent tasks of developing the raw material base for cement production and resource conservation were solved. The development of new initial mixtures was carried out taking into account the peculiarities of the chemical and mineralogical composition of varieties of technogenic raw materials. According to the chemical composition, rice alkali is characterized by a content of 15.6 wt. % SiO2 with a large quantitative ratio of SiO2:Al2O3=65.2 and a small amount of alkaline earth and alkaline oxides. Scop differs from alkali in a large amount of CaO (25.8 wt. %), a lower content of SiO2 at a quantitative ratio of SiO2:Al2O3=1.3. In this case, there are quantitative ratios of oxides CaO:SiO2=2.5, CaO:Al2O3=3.3, CaO:SiO2:Al2O3=3.3:1.4:1, which determine the probable phase transformations during firing. The main rock-forming mineral in rice husks is amorphous silica; Scope is marked by the presence of crystalline phases of calcite, quartz, and kaolinite. The analysis of the possible content of the studied wastes and the determination of the compositions of the raw mixtures were carried out using the computer program «Clinker». Analysis of computer calculations and experiments indicates the possibility of reducing by 11–16 wt. % consumption of natural raw materials in the composition of mixtures for the manufacture of clinker in comparison with the known production composition. According to X-ray phase analysis, the features of the development of crystalline phases during the firing of mixtures using varieties of technogenic raw materials at a maximum temperature of 1400 ºС were established. Based on the data of technological testing, the differences in indicators of binding properties were determined - the setting time of cement when used in the composition of raw mixtures of rice husk and paper scope.
Assessment of the impact of traffic conditions on the availability of transport services of the city bus route
Authors: Vdovychenko Volodymyr , Ivanov Igor , Pidlubnyi Serhii
Published: August 2022

The object of research is the influence of the conditions for the implementation of technological trip operations in the implementation of the priority movement of urban passenger transport on the bus route on the level of accessibility of the transport service. On the basis of the developed contour of information communication, a typical procedure for establishing the parameter for assessing the availability of a transport service, depending on the time indicators of traffic on the route, is singled out. As a controlled parameter that determines the conditions for increasing the availability of a transport service, the trip time and the range of deviations in the arrival of buses to the stopping point are singled out. Implemented on the basis of simulation modeling, the procedure for establishing the correspondence between the time parameters of the departure of buses from the stopping point and the formation of demand made it possible to establish patterns of changes in the level of accessibility of the transport service depending on the traffic conditions on the route.
In the course of field observations along route No. 115e «Gagarin avenue metro station – Nesterov street» (Kharkiv, Ukraine) it was found that the introduction of free traffic conditions that meet the conditions of the priority of urban passenger transport can reduce the duration of the trip by 5 min and reduce the range of deviation of the arrival of buses to the stopping point by 4 min. On the basis of experimental studies, it was found that by reducing the duration of the trip from 32 min up to 27 min it is possible to increase the value of the transport service accessibility indicator by 20.5 %. When organizing traffic according to a schedule, it is possible to increase the indicator of the availability of transport services up to 0.679 (by 6.8 %). The introduction of priority traffic on route No. 115e allows reducing the trip time to 22–27 min, which will positively affect the indicator of the availability of transport services (increase to 0.803 in traffic without a schedule and up to 0.880 in compliance with the traffic schedule). Reducing the range of bus arrival deviations in the range from –1 min up to +2 min allows increasing the level of accessibility of transport services under normal conditions from 6.8 % to 13.3 %, and with the introduction of priority traffic – from 15.4 % to 18.3 %.
Modification of scaled equation of state to determine the pressure in the CO2 critical region
Authors: Vorobiova Hanna
Published: August 2022

The object of the research is carbon dioxide and its pressure distribution depending on the range of temperature and density in the region of the critical point. One of the most problematic areas of methods for finding thermodynamic parameters of a real gas is insufficient accuracy in calculations in the places of occurrence and rapid development of fluctuation phenomena, which are inherent in phase transitions of the first and second terms. For a more detailed and accurate description of the nature of the thermodynamic parameters in the region of the critical point, scaling and crossover equations of state were developed. Such equations, due to the presence of regular and scaling parts, allow describing the thermodynamic parameters of a real gas not only directly near the critical point, but also at some distance from it, maintaining a small error relative to experimental data. The article proposes an equation of state, which contains a scaling part described according to the rules of statistical physics, and a regular part in the form of a classical cubic equation of state. The equation is used to calculate the pressure of carbon dioxide in the region around the critical point from 300 K to 305 K. The article proposes a correlation equation for the scaling correction of the regular part (Redlich-Kwong-Aungier model) of the crossover equation of state, which is related to the scaling part the equation of state is a crossover function. The obtained results for the pressure in the critical region showed good agreement with the baseline data. The error relative to the experimental data is halved compared to the original model of the Redlich-Kwong-Aungier equation. The obtained results ensure the applicability of the proposed method in the temperature range from 300 K to 305 K. Due to the simplicity of the form of the regular equation of state and the small number of empirical coefficients for the large-scale equation of state, the obtained method can be used for practical problems of computational hydrodynamics without spending a lot of computing time.
A CONCEPÇÃO DE TEMA NAS OBRAS DO CÍRCULO DE BAKHTIN
Authors: FUZA Ângela Francine , RODRIGUES Rosângela Hammes
Published: August 2022

RESUMO O estudo da significação é uma das problemáticas mais complexas da Linguística, segundo os pressupostos de Bakhtin e do Círculo. Nesse ínterim, o tema, um dos conceitos-chave, embora não seja o mais estudado pelo Círculo, torna-se essencial para a compreensão da linguagem como ação concreta. Este artigo, de escopo bibliográfico, objetiva discutir, epistemológica e teoricamente, a concepção de tema e os conceitos a ele relacionados nos trabalhos do Círculo, especificamente, Bakhtin, Volochínov e Medviédev. Para tanto, o texto retoma as considerações a respeito do tema nas obras desses autores, a observar seu desdobramento, no decorrer dos anos. Os resultados apontam que há variações, nos textos, em relação ao conceito, o que possibilitou depreender algumas tendências em seu entendimento: (1) tema como o sentido total da enunciação, o acontecimento, a realidade e o momento no qual, axiologicamente, interagem conteúdo e forma; (2) tema como a relação entre significação e valoração do signo ideológico; e (3) tema como objeto da enunciação/do enunciado.
Agentes comunitárias de saúde com ensino superior: normas, saberes e currículo
Authors: Méllo Lívia Milena Barbosa de Deus e , Santos Romário Correia dos , Albuquerque Paulette Cavalcanti de
Published: August 2022

Resumo Este artigo tem como objetivo analisar como as graduações em Enfermagem, Serviço Social, Psicologia ou Pedagogia cursadas pelas agentes comunitárias de saúde podem influenciar seus saberes, práticas e os rumos da profissão. Trata-se de pesquisa qualitativa, analítica, com triangulação de métodos baseada na interpretação dos diversos sujeitos que disputam a profissão. O artigo é desenvolvido em três partes: a primeira compara aspectos normativos das categorias profissionais; a segunda discute os saberes das agentes comunitárias de saúde após ingresso no ensino superior e a influência nas práticas profissionais; e a terceira analisa os currículos de Enfermagem, Serviço Social, Psicologia, Pedagogia e agentes comunitárias de saúde como elemento de disputa e construção das identidades profissionais. Apontam-se lacunas quanto à ausência de um projeto ético-político e de associação de ensino e pesquisa própria das agentes comunitárias de saúde, assim como a necessária disputa das epistemologias e fundamentação teórica para se alcançar um domínio cognitivo e profissional mais comprometido com a transformação das agentes como sujeito e da sua realidade.
CFRP-strengthened RC beams under fire condition: numerical model
Authors: Carlos Thiago Brazeiro , Silva Valdir Pignatta e
Published: August 2022

Abstract The Carbon Fiber Reinforced Polymer (CFRP) has excellent flexural performance on strengthening and rehabilitation of reinforced concrete (RC) structures. However, it is known that CFRP strengthening systems are very vulnerable to high thermal exposure. To provide a better understanding of its fire behavior and fulfill gaps in this field, this investigation proposes the development of an accurate three-dimensional (3D) Finite Element (FE) model capable of simulating the CFRP-strengthened RC beams flexural behavior at ambient temperature and under fire conditions. To achieve the goals, thermal and mechanical numerical simulations have been performed to validate the developed FE models. Experimental results reported in two parallel studies were used to model’s validation. The numerical model has been satisfactorily validated and the results had a good predictability with the experimental results in terms of thermal and mechanical behavior.
KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency–Related Polycystic Kidney Disease
Authors: Rah Gyuyeong , Cha Hwayeon , Kim Joohee , Song Jieun , Kim Hyunho , Oh Yun Kyu , Ahn Curie , Kang Minyong , Kim Jongmin , Yoo Kyung Hyun , Kim Min Jung , Ko Hyuk Wan , Ko Je Yeong , Park Jong Hoon
Published: August 2022

Significance Statement

Mutations in ciliogenesis-associated kinase 1 (CILK1) cause ciliopathies. However, the pathogenesis of the ciliary defect in the CILK1-deficient kidney remains unknown. We found that CILK1 deficiency in a mouse model leads to polycystic kidney disease (PKD) with abnormal ciliary trafficking and that kinesin light chain–3 (KLC3), a novel ciliary regulator, interacts with CILK1. Furthermore, KLC3 localizes at cilia bases, where it promotes ciliary trafficking of the IFT-EGFR complex, which contributes to cyst progression. KLC3 knockdown restored abnormal ciliary trafficking and cyst progression caused by CILK1 deficiency. Identifying KLC3 as a ciliary regulator involved in cystogenesis provides insights into the pathogenesis of CILK1 deficiency–related PKD.

Background

Ciliogenesis-associated kinase 1 (CILK1) is a ciliary gene that localizes in primary cilia and regulates ciliary transport. Mutations in CILK1 cause various ciliopathies. However, the pathogenesis of CILK1-deficient kidney disease is unknown.

Methods

To examine whether CILK1 deficiency causes PKD accompanied by abnormal cilia, we generated mice with deletion of Cilk1 in cells of the renal collecting duct. A yeast two-hybrid system and coimmunoprecipitation (co-IP) were used to identify a novel regulator, kinesin light chain–3 (KLC3), of ciliary trafficking and cyst progression in the Cilk1-deficient model. Immunocytochemistry and co-IP were used to examine the effect of KLC3 on ciliary trafficking of the IFT-B complex and EGFR. We evaluated the effects of these genes on ciliary trafficking and cyst progression by modulating CILK1 and KLC3 expression levels.

Results

CILK1 deficiency leads to PKD accompanied by abnormal ciliary trafficking. KLC3 interacts with CILK1 at cilia bases and is increased in cyst-lining cells of CILK1-deficient mice. KLC3 overexpression promotes ciliary recruitment of IFT-B and EGFR in the CILK1 deficiency condition, which contributes to the ciliary defect in cystogenesis. Reduction in KLC3 rescued the ciliary defects and inhibited cyst progression caused by CILK1 deficiency.

Conclusions

Our findings suggest that CILK1 deficiency in renal collecting ducts leads to PKD and promotes ciliary trafficking via increased KLC3.
AN EMERGING FACTOR IN TURKISH ANTI-DUMPING POLICY: ADDITIONAL CUSTOMS DUTY
Authors: AKBAŞ Serdar
Published: August 2022

The purpose of this study is to explain the determinants of anti-dumping investigations in Turkey, which is one of the most frequent users of anti-dumping investigations among World Trade Organization (WTO) members. Following rising global protectionism after 2012, the implementation of new measures gained prominence among many countries. Most notable of these new changes is the extensive use of Additional Customs Duty (ACD) in Turkey. The study examines this policy tool for the first time in the literature regarding anti-dumping determinants. Negative binomial regression models used for 1989-2019 period to illustrate different variables such as retaliation motives, deterioration in trade deficit, productivity of the manufacturing sector and real GDP growth as important factors affecting investigative efforts. The findings indicate that certain protectionist motives matter more in anti-dumping investigations rather than unfair competition dynamics. Thus, ACD policy seems to keep its importance to reduce anti-dumping investigation initiations against some countries over time.
The Role of Community Health Workers in Oral Health Promotion and the Impact of their services in Sub-Saharan Africa: A Systematic Review.
Authors: Khan Mohammed Azhar , Okeah Bernard Ojiambo , Mbivnjon Etheldreda Leinyuy , Kisangala Ephraim , Pritchard Aaron Wyn
Published: August 2022

Oral ailments are largely preventable but remain a significant public health concern afflicting nearly half the global population. These conditions account for 220 years of life lost per 100,000 people and about US$500 billion in health-related expenditures. SubSaharan Africa bears a significant burden of oral health problems thus exerting additional pressure on the scarce human resources for health. Community healthcare workers (CHWs) could be potentially utilised to bridge the shortage of oral health professionals in sub-Saharan Africa, hence, this systematic review that seeks to explore their current roles in oral health and potential impact on general physical health. This review follows the PRISMA guidelines and databases searched include PubMed, Web of Science, Medline, and CINAHL published between January 2010 and December 2019. Nine studies met the study eligibility criteria. The authors of this review established that CHWs perform variable roles cutting across primary, secondary, and tertiary prevention including providing oral hygiene education, recognising common pathologies, and treating oral lesions, administration of tooth extractions, dental pain management, and referral for advanced care. Although this could potentially improve oral health, our review did not establish the extent of the specific impact on general physical health of patients and the burden of oral condition.
Laser Capture Microdissection of Tissue Functional Units for microPOTS Top-Down Proteomics v1
Authors: M Fulcher James
Published: August 2022

In this protocol, we describe a detailed procedure for high-resolution top-down proteomic analysis of human pancreatic and kidney tissue sections using a spatial proteomic platform by combining laser capture microdissection (LCM), microPOTS (microdroplet processing in one pot for trace samples), and nanoflow liquid chromatography mass spectrometry (LC-MS). This protocol has been applied to human pancreatic and kidney specimens for HubMAP Tissue Mapping Centers. Expected outcome: Identification of >300 proteoforms at 100-µm spatial resolution depending on sample types and LC-MS instrumentation.
Protocol for a nationwide systematic review of the Greek literature on child and adolescent mental health v1
Authors: not provided lauromarchionatti
Published: August 2022

This is a landscape analysis of scientific literature to map available resources and trace research priorities on child and adolescent mental health in Greece. We describe a nation-wide systematic review of prevalence surveys, assessment instruments, and interventions for mental health conditions among children and adolescents within the country. A multi-step search procedure with English and Greek terms retrieves studies from several electronic databases (Medline, Web of Science, PsycINFO, IATPOTEK, and Google scholar), which are then classified into each research area according to inclusion criteria. Snowballing inclusion and expert consulting complements the set of studies. Different extraction procedures and data synthesis strategies are described for prevalence studies, assessment instrument studies, and interventions studies. The methodological quality is ascertained with specific tools for each study design.
Industrielles Transfer-Lernen
Authors: Vietz Hannes , Maschler Benjamin , Tercan Hasan , Bitter Christian , Meisen Tobias , Weyrich Michael
Published: August 2022

Trotz hoher Lösungspotenziale des maschinellen Lernens für gängige Probleme der Automatisierungstechnik finden sich in der Praxis wenig Anwendungsbeispiele. Um der Ursache hierfür auf den Grund zu gehen, zeigen die Autoren anhand von vier beispielhaften Anwendungsfällen die Hürden für konventionelles maschinelles Lernen auf und benennen Lösungsansätze mittels industriellem Transfer-Lernen. Zum großflächigen Einsatz derartiger Ansätze, fehlt es an Voraussetzungen, deren Schaffungjedoch anders als beim konventionellen maschinellen Lernen grundsätzlich möglich ist. Der Artikel schließt mit einer Betrachtung dieser Voraussetzungen und macht Vorschläge, wie sie zu erfüllen sind.
Using Domain-Knowledge to Improve Machine Learning
Authors: Rensmeyer Tim , Multaheb Samim , Putzke Julian , Zimmering Bernd
Published: August 2022

Machine Learning methods have achieved some impressive results over the past decade. However, this success was in large part a result of utilizing large amounts of data and growing computational resources efficiently. To extend this recent success to domains where large quantities of high-quality data are not readily available, the field of informed machine learning has emerged, which aims at integrating preexisting knowledge into machine learning models. The aim of this paper is to provide an overview of the major new developments in this field and to discuss important open problems.
SEMANTIC NUANCES OF THE CATEGORY OF PERSUASION IN RHETORIC
Authors:   Taras Shevchenko National University of Kyiv, Komakha Larysa , Kolotilova Nataliia ,   Taras Shevchenko National University of Kyiv
Published: August 2022

The article deals with the semantic nuances of the category of persuasion in rhetoric. Based on the study of classical and modern works in the field of rhetoric, the distinction between conviction and persuasion as an influence on the understanding and influence on the will, which was characteristic of the Western classical philosophical tradition (G. Campbell, I. Kant, R. Whately), is emphasized. Thus conviction assumes actually influence by means of arguments, and persuasion both reasoned, and pathetic influence. In the 20th century in the concept of "new rhetoric" by Ch. Perelman and L. Olbrechts-Tyteka, these differences also lie in the nature of the audience (universal or particular) to which the speaker's argumentation is addressed. At the same time, they reconsider I. Kant's criterion "objective-subjective", because arguments aimed at a particular audience also have a meaning that goes beyond subjective belief. In D. O'Keefe's modern theory of persuasion, the distinction between conviction and persuasion remains at the level of the speaker's communicative ends, but does not mean a clear difference between the communicative means of achieving these ends. In the Ukrainian language there is only one term to denote this category, however, in the modern educational literature grasps the above-mentioned nuances in defining persuasion as characteristics of theoretical and practical activities, which indicates the move of the Ukrainian educational field in the stream of European traditions of rhetoric interpretation.