bluuebunny/crossref_metadata_2025 huggingface dataset:
Gas-Containing Renal Stones: A Case Report and Literature Review
Authors: Benjamin Lim Tze Ying , Benjamin Lim Tze Ying , Sey Kiat Lim , Li-Tsa Koh
Published: July 2020

We report the 11th case of gas containing renal stone. A 92-year-old Chinese female presented with fever
and lower urinary tract symptoms. Urine culture grew Escherichia coli (E. coli). CT abdomen pelvis showed
a large gas containing partial staghorn stone. She was managed conservatively with two weeks of antibiotics.
Follow up plain kidney, ureter and bladder (KUB) radiograph at 3 months showed that the stone was stable
in size. She remained asymptomatic at follow up.
Basal Cell Carcinoma of the External Auditory Canal – Unusual Site: A Case Report
Authors: Mohamed Eman Nagy , Mohamed Eman Nagy , Elshahat Ahmed
Published: July 2020

Malignant tumor originated from external auditory canal (EAC) is very rare with an annual incidence of
around 1 per million. Yet, basal cell carcinomas are less frequent than squamous cell carcinomas.
Nevertheless, it is difficult to determine if their prognosis is better, as in other areas of the body. Due to the
rarity of malignant tumor of EAC, there is no widely accepted treatment modality yet. But basal cell
carcinoma, is known to be less aggressive tumor than squamous cell carcinoma and can be removed with a
minimal safety margin and has a better treatment result. In this case report, we experienced a case of basal
cell carcinoma (BCC) in the EAC, confined in the cartilaginous portion of EAC, presented with intermittent
otorrhea and pruritis in the right ear. The patient was treated with local excision of the lesion with a safety
margin and direct closure. No recurrence or complications were noted in the first postoperative year.
A Case of Giant Primary Pleuropulmonary Synovial Sarcoma
Authors: Vigneswaran Wickii T. , C. Fields Brittany , Ananthanarayanan Vijayalakshmi , Vigneswaran Wickii T.
Published: July 2020

Synovial sarcomas represent an extremely rare subtype of an already rare group of malignancies, soft tissue
sarcomas. Among these, primary pulmonary synovial sarcomas comprise an even smaller number, though
they have become more frequently reported in the literature. This case report details a case of giant primary
pulmonary synovial sarcoma in a 44-year-old male patient who presented with left-sided chest pain and
shortness of breath and was found to have a large left-sided pleural effusion. No malignant cells were
demonstrated on cytology of pleural fluid after thoracentesis; however, CT-guided needle biopsy of pleural
nodules seen on imaging demonstrated pathologic features consistent with monophasic type synovial
sarcoma. He was treated with neoadjuvant chemotherapy with minimal response; thus, he was referred for
surgical management. A left extrapleural pneumonectomy with resection of the left hemi-diaphragm and
Gore-Tex prosthetic reconstruction was performed. Imaging at six-month follow-up demonstrated a new
nodule in the contralateral lung, suggestive of metastasis at that time and the patient later developed ascites
at nine months, consistent with further intra-abdominal metastasis. Perhaps early diagnosis and aggressive
multimodality therapy may have a place in the treatment of this aggressive disease.
Metabolomics of Rat Brain After Treatment with Phenelzine: High-Resolution Mass Spectrometric Demonstration of Increased Brain Levels of N-Acetyl Amino Acids
Authors: Wood Paul L. , Wood Paul L. , Cebak John E. , Baker Glen B.
Published: July 2020

Background: Phenelzine (PLZ) is a non-specific monoamine oxidase inhibitor that has demonstrated
clinical efficacy in patients with treatment resistant depression. The mechanism of action with regard to this
efficacy is complicated in that its metabolite, β-phenylethylidenehydrazine (PEH), is an inhibitor of amino
acid transaminases resulting in dramatic brain elevations of GABA, alanine, ornithine and tyrosine. The full
neurochemical profile of PLZ and PEH remain to be explored.
Objective: To undertake a non-targeted metabolomics study of phenelzine on rat brain neurochemistry.
Methods: We undertook a high-resolution mass spectrometric metabolomics analysis of rat cortical brain
1 and 12 hours after intraperitoneal dosing with PLZ or PEH. Tandem mass spectrometry was utilized to
obtain relative quantitation data.
Results: N-acetyl amino acids were found to be elevated in cortical brain tissue following either PLZ or
PEH treatments.
Conclusions: Our data indicate PLZ treatment significantly augments brain levels of N-acetyl amino acids
and that this may involve inhibition of deacylases by PEH and/or induction of N-amino acid
acetyltransferases.
PERBEDAAN PENGARUH METODE LATIHAN DAN MOTIVASI BERLATIH TERHADAP TEKNIK DASAR SEPAKBOLA SEKOLAH SEPAKBOLA BEJI TIMUR U-13
Authors: Okilanda Ardo , Dlis Firmansyah , Humaid Hidayat , Putra Dede Dwiansyah
Published: July 2020

Penelitian ini bertujuan mengetahui perbedaan pengaruh metode blocked practice, random practice  dengan motivasi berlatih tinggi dan rendah terhadap kemampuan teknik dasar sepakbola. Penelitian ini menggunakan treatment by level 2 x 2. Sampel dengan 40 siswa Sekolah sepakbola Beji Timur U-13. Teknik analisis data adalah analisis varians dua jalur (ANAVA) dan selanjutnya dilanjutkan dengan uji Tuckey pada tingkat signifikansi α = 0,05. Hasil penelitian menjawab (1). Ada perbedaan pengaruh siginifikkan metode blocked practice (A1) motivasi latihan tinggi dengan random practice (A2) motivasi latihan tinggi terhadap kemampuan teknik dasar sepakbola blocked practice (X=51,801 ; SD=7,135) lebih tinggi dari metode random practice (X=48,198 ; SD=5,514). (2). Ada perbedaan pengaruh signifikkan metode blocked practice (A1) motivasi latihan rendah dengan random practice (A2) motivasi latihan rendah terhadap kemampuan teknik dasar sepakbola metode blocked practice motivasi berlatih rendah Qo = -2,369 dan Qt = 3,89 lebih rendah dari nilai teknik dasar dalam sepakbola metode random practice motivasi berlatih rendah. Aspek motivasi interinsik dan ekstrinsik perlu yang lebih luas.
TANTANGAN DALAM MENINGKATKAN KEMAMPUAN BERBICARA MAHASISWA DENGAN METODE PEMBELAJARAN WAWANCARA
Authors: Syaputri Wuri , Septianasari Lina , Abqoriyyah Fourus Huznatul
Published: July 2020

Penelitian ini menjawab permasalahan tentang kefektifan metode pemelajaran wawancara di kelas berbicara mahasiswa. Selain itu, penelitian ini juga melihat tantangan dosen dalam pemelajaran berbicara. Praktik bahasa dalam kelas diamati dan diberi eksperimen adalah kelas Speaking pada level beginner di Universitas Muhammadiyah Pringsewu. Mahasiswa yang menjadi subjek penelitian berjumlah 72 mahasiswa. Seluruh mahasiswa akan mendapatkan perlakuan sesuai dengan kebutuhan penelitian. Hasil penghitungan statistik t-test menunjukkan, dimana t-test 4,66 lebih tinggi dari t-table adalah 2,06 itu berarti hipotesis Ha dalam penelitian ini diterima. Berdasarkan catatan hasil pengamatan, metode wawancara juga belum berhasil sempurna untuk mengajak mahasiswa menjadi aktif di kelas. Hal ini menjadi perhatian karena masih muncul 5 mahasiswa yang memilih diam ketika diajak berbicara oleh dosen.
PENERAPAN MODEL DIRECT INTRUCTION UNTUK MENINGKATKAN HASIL BELAJAR BIOLOGI
Authors: Candrawati Ed.
Published: July 2020

Penelitian ini bertujuan untuk mendeskripsikan  kegiatan pembelajaran dan kegiatan belajar dengan model pembelajaran langsung (Direct Instruction) serta hasil belajar dengan penerapan model pembelajaran langsung (Direct Instruction) di kelas X MIPA 4 SMA Negeri 1 Jalaksana. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) atau classroom Action Research dengan metode deskriptif  yang menggunakan dua siklus, masing-masing siklus terdiri dari empat tahap sebagai berikut: tahap perencanaan, tahap pelaksanaan, tahap observasi dan tahap refleksi. Subjek penelitian adalah peneliti sebagai guru Biologi dan seluruh siswa kelas X MIPA 4 SMA Negeri 1 Jalaksana yang berjumlah 36 orang. Teknik pengumpulan data yang digunakan adalah observasi dan tes. Sedangkan instrumen penelitian terdiri dari lembar observasi dan lembar tes. Lembar observasi digunakan untuk mendeskripsikan kegiatan pembelajaran dan belajar pada model pembelajaran langsung dan lembar tes digunakan untuk mendeskripsikan hasil belajar biologi siswa yang merupakan soal berupa pilihan ganda. Hasil analisis data observasi kegiatan pembelajaran oleh guru  siklus 1 diperoleh rata-rata skor kegiatan belajar yaitu 16 pada siklus 1 dengan kategori cukup dan meningkat menjadi 21 pada siklus 2 dengan kategori baik. Pada siklus 1 nilai rata-rata kelas yaitu 68,64 dengan persentase ketuntasan belajar klasikal 56% (tidak tuntas) pada siklus 2 meningkat nilai rata-rata kelas menjadi 85,91 dengan persentase ketuntasan belajar klasikal 81% (tuntas). Disimpulkan bahwa model pembelajaran langsung dapat meningkatkan kegiatan pembelajaran oleh guru dan kegiatan belajar oleh siswa serta  hasil belajar  biologi siswa dikelas X MIPA 4 SMA Negeri 1 Jalaksana.
PENERAPAN MODEL PROBLEM BASED LEARNING UNTUK MENINGKATKAN MOTIVASI DAN PRESTASI BELAJAR EKONOMI SISWA
Authors: Suryati Titi
Published: July 2020

Penelitian ini bertujuan untuk meningkatkan motivasi dan prestasi belajar peserta didik kelas XI IPS 4 SMA Negeri 1 Jalaksana tahun pelajaran 2019/2020 melalui pembelajaran model Problem Based Learning. Penelitian ini merupakan penelitian tindakan kelas (PTK) yang dilaksanakan dalam dua siklus. Analisis data pada penelitian ini berpedoman pada analisis Statistik Deskriptif dengan Persentase. Teknik pengumpulan data dilakukan dengan tes tertulis, angket, dan observasi. Motivasi peserta didik dilihat dengan menggunakan observasi dan angket. Hasil penelitian ini menunjukan adanya peningkatan motivasi belajar peserta didik dari siklus I ke siklus II pada kuesioner motivasi belajar siswa sebesar 13,39% pada kategori tinggi dan sangant tinggi. Sedangkan peningkatan prestasi belajar ditandai dengan bertambahnya peserta didik yang nilainya mencapai kriteria ketuntasan minimal secara keseluruhan. Pada siklus I sebesar 67,86% atau sebanyak 19 siswa mencapai kriteria ketuntasan minimal. Pada siklus II terjadi  peningkatan peserta didik yang mencapai nilai ketuntasan minimal sebesar 85,71 % atau sebanyak 24 siswa. Jadi dapat disimpulkan bahwa Penerapan Model Problem Based Learning Untuk Meningkatkan Motivasi Dan Prestasi Belajar Ekonomi Siswa Kelas XI IPS 4 SMA Negeri 1 Jalaksana Tahun Pelajaran 2019/2020 meningkat.
PENINGKATAN KEMAMPUAN MENULIS TEKS EKSPOSISI DENGAN MENGGUNAKAN STRATEGI THINK-TALK-WRITE
Authors: Rosdiana Deni
Published: July 2020

Penelitian ini bertujuan untuk (1) meningkatkan kualitas proses pembelajaran menulis teks eksposisi siswa kelas X MIPA 5 SMA Negeri 1 Jalaksana  dengan strategi ThinkTalk-Write; dan (2) untuk meningkatkan  kualitas hasil pembelajaran menulis teks eksposisi siswa kelas X MIPA 5 SMA Negeri 1 Jalaksana  dengan  strategi ThinkTalk-Write. Penelitian ini berjenis penelitian Tindakan Kelas (PTK) dengan teknik deskriptif kualitatif yang dilaksanakan di kelas X-MIPA 5 SMA Negeri 1 Jalaksana. Pengambilan data penelitian menggunakan prosedur perencanaan,tindakan,pengamatan, dan refleksi. Hasil dari penelitian ini membuktikan bahwa keterampilan menulis teks eksposisi pada siswa kelas XMIPA 1 SMA Negeri 1 Jalaksana mengalami peningkatan setelah dilakukan pembelajaran menulis teks eksposisi dengan strategi Think-Talk-Write. Hasil tes menulis teks eksposisi pada siklus I menunjukkan nilai rata-rata 77,42 dan pada siklus II menunjukkan nilai rata-rata 84,06. Dari hasil tersebut dapat diketahui peningkatan keterampilan siswa dalam menulis teks eksposisi dari siklus I ke siklus II sebesar 6,64 poin atau 18,44%. Selain peningkatan keterampilan, perilaku siswa kelas X-MIPA 5 SMA Negeri 1 Jalaksana juga mengalami perubahan ke arah yang lebih positif setelah dilakukan pembelajaran menulis teks eksposisi dengan strategi Think-Talk-Write.
PENINGKATAN AKTIVITAS DAN HASIL BELAJAR SISWA MELALUI PENERAPAN METODE SNOWBALL THROWING PADA MATA PELAJARAN EKONOMI
Authors: Nirmala Emalya
Published: July 2020

Penelitian ini bertujuan untuk meningkatkan aktivitas dan hasil belajar ekonomi kelas XI IPS 1 melalui penerapan metode pembelajaran Snowball Throwing (Bola Salju) pada mata pelajaran ekonomi di SMA Negeri 1 Temon Tahun Ajaran 2020/2020. Melalui metode Snowball Throwing ini diharapkan siswa mampu mencapai tujuan peningkatan aktivitas dan hasil belajar ekonomi. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang dilakukan dalam dua tahapan siklus. Siklus I terdiri dari dua kali pertemuan dan siklus II terdiri dari satu kali pertemuan. Setiap siklus terdiri dari empat tahap yaitu perencanaan, pelaksanaan tindakan, pengamatan dan refleksi. Subjek dalam penelitian ini adalah siswa kelas XI IPS 1 SMA Negeri 1 Jalaksana yang berjumlah 31 siswa. Indikator keberhasilan pada penelitian ini adalah apabila 75% siswa aktif terlibat dalam pembelajaran dan juga terjadi peningkatan hasil belajar pada tiap siklus melalui post test dan apabila 75% siswa dapat mencapai nilai Kriteria Ketuntasan Minimal (KKM) yang ditentukan oleh sekolah yaitu 75. Hasil penelitian menunjukkan bahwa dengan penerapan metode Snowball Throwing  di kelas XI IPS 1 skor aktivitas belajar siswa pada masing-masing indikator secara keseluruhan meningkat 10%, dari rata-rata siklus I sebesar 71% menjadi 81% pada siklus II. Peningkatan ketuntasan hasil belajar siswa meningkat dari siklus I sebanyak 22 siswa (71%) menjadi 25 siswa (81%) yang mencapai nilai KKM pada siklus II.
MENINGKATKAN HASIL BELAJAR MATEMATIKA PADA SISWA MELALUI PEMBELAJARAN MATEMATIKA REALISTIK
Authors: Susnariah Uus
Published: July 2020

Tujuan penelitian ini adalah untuk meningkatkan hasil belajar Matematika kelas VI A melalui Pembelajaran Matematika Realistik di SDN Cigintung Kecamatan Kuningan, Kabupaten Kuningan. Subjek penelitian ini adalah siswa kelas VI A SDN Cigintung, Kecamatan Kuningan, Kabupaten Kuningan tahun pelajaran  2019/2020 yang berjumlah 25 siswa. Peningkatan sikap siswa tersebut sejalan dengan peningkatan hasil tes yang diperoleh. Hasil belajar kognitif mengalami peningkatan 26,67% yaitu dari siklus I sebesar 53,33% (12 siswa) menjadi 80% (20 siswa) pada siklus II. Pada siklus II persentase keberhasilannya sudah mencapai ≥ 75% sehingga siklus ini dihentikan. Berdasarkan hasil observasi sikap siswa siklus I, dilihat dari beberapa aspek sikap siswa yang terdiri dari: 1) siswa telah berusaha mengerjakan permasalahan matematika dengan cara sendiri; 2) siswa berusaha menyelesaikan permasalahan matematika sesuai langkah-langkah yang telah dipelajari; 3) siswa berusaha untuk bertanya apabila ada yang belum dimengerti dalam pembelajaran matematika dan 4) siswa berusaha mengaitkan antara konsep matematika dengan kehidupan sehari-hari diperoleh hasil rata-rata sikap siswa pada mata pelajaran matematika mencapai 58,33% (dari 25 siswa) sedangkan pada siklus II diperoleh hasil rata-rata sebesar 77,5% (dari 25 siswa). Berdasarkan hasil tersebut maka sikap siswa telah dikatakan meningkat dan mencapai indikator keberhasilan yaitu 75% dari 25 siswa telah menunjukkan sikap berusaha untuk berpikir berdasakan lembar observasi yang telah dibuat.
DELVING THE HOOK SENTENCE IN ARGUMENTATIVE ESSAY: FINDING THE WRITERS’ PREFERENCES OF CATCHY SENTENCE
Authors: Rahman Yenni Arif
Published: July 2020

Hook sentences as an opener and attention grabber in introductory paragraph play important role to make readers keep reading an essay. This means the structure and preferences to produce the hook is a key point to an interesting essay. The study aims to identify the writers’ preferences to write hook sentences. The data were 40 argumentative essays collected from 7 different international newspapers and gazettes. The study employs content analysis procedure to analyze 4 related categories to preferences: theme, number of words, types of sentence, and types of hooks. The subcategories which consist of 13 items is created to supply the detailed preferences. The result shows that all 40 samples utilize theme-related hook, with 34 (85%) samples written with more than 10 words, without dominant types of sentences (simple, compound, and complex), and with 23 (58%) narrative or story hook. From the result, it can be inferred that the writers prefer hook-related theme with mostly narrative type hook. The result also shows that there is relatively fair preference between simple and complex sentence use.
Design, Rheology and Physicochemical Characterizations of Oil-in-water Emulsions Stabilized by Waxy Starch Derivatives
Authors: Ezzeroug Kaouther , Moulai-Mostefa Nadji
Published: July 2020

Simple emulsions (o/w) stabilized by octenyl succinic anhydrous (OSA) starch were studied. They were characterized by the evaluation of the rheological and physicochemical properties and, the observation under the light microscope in combination with granulometric analysis after formulation. The obtained results demonstrated the effects of the amount of OSA starch on the variation of the diameter of particles, stability of emulsions and their rheological behavior. The best characteristics were found in the emulsion with a ratio 40/60 (o/w) at high OSA starch concentration, because the substitution of the oil phase by the network created by the chains of the modified polysaccharides which could be the major factor in stabilisation of emulsions.
Teachers’ Professional Ethics and Classroom Management as a Correlate of Students’ Academic Performance in Public Secondary Schools in Abia State, Nigeria
Authors: Chukwu Chukwuemeka Joseph , Ezepue Evelyn Ijeoma , Evelyn Kalu-mba , Iremeka Ukamaka Felicia , Onyemaechi Nweke Prince , Vivian Madu Chioma , Uwakwe Iro Stephen
Published: July 2020

The study examined teachers’ professional ethics and classroom management as a correlate of students’ academic performance in public secondary schools in Abia State, Nigeria. Two research questions and two null hypotheses guided the study. The study adopted a Correlational Research Design. The population of the study consisted of 9,200 Secondary School Students in Public Secondary Schools. The study sampled 920 students representing 10% of the populations using Stratified Random Sampling Technique. The instrument for data collection was structured questionnaire titled: “Teachers’ Professional Ethics and Classroom Management of Students Academic performance (TPECMSAP)”. The instrument was validated by three experts. The instrument was tested using t-test method and calculated with Pearson’s Product Moment Correlation which yielded an index of 0.71 for teachers’ professional ethics and 0.89 for classroom management. Data collected was analyzed using mean and standard deviation to answer the research questions. Pearson’s r, R2 (coefficient of determination) and multiple regression analysis was used to test the null hypotheses at 0.05 levels of significance. The findings of the study revealed that there is a significant relationship between teachers’ professional ethics, classroom management and students academic performance. The findings of the study revealed that employment of qualified teachers and other professionals’ demands for practices to ensure high academic performance. Based on the findings, it was recommended among others that government and the school administrators should organize seminars, workshops and conferences to create more awareness on teachers’ ethics and classroom managements on academic performance of students in Nigeria.
Kontestasi Kuasa Kepemimpinan Formal dengan Informal dalam Kebijakan Publik dan Politik Keseharian
Authors: Mayrudin Yeby Ma'asan , Husna Nabilla Amalia , Yuliati Fanny Rosye
Published: July 2020

Artikel ini membedah tentang dinamika kontestasi kuasa kepala desa sebagai pemimpin formal dengan Abah Olot yang merupakan kepala adat sebagai aktor informal dalam kebijakan publik dan politik keseharian di Desa Adat Guradog, Kecamatan Curugbitung, Kabupaten Lebak, Provinsi Banten. Persoalan tersebut menunjukkan adanya persilangan kontestasi kuasa antara aktor. Interseksi ini memunculkan pertarungan kuasa dominatif di antara kedua aktor tersebut. Oleh karena itu, tim penulis menelusuri praktik relasi kuasa yang terjadi agar mampu dijadikan sebagai refleksi untuk membenahi problematika itu. Dalam menyelisik fenomena tersebut, tim penulis menggunakan kerangka teori Kepemimpinan dan Shadow State yang dimanfaatkan sebagai pisau analisa. Adapun metode penelitiannya memakai metode kualitatif deskriptif. Metode jenis ini mampu mengejawantahkan data deskriptif terkait dengan pokok persoalan dalam artikel ini. Alhasil, tulisan ini membuktikan manifestasi kuasa hegemonik pemimpin informal terhadap kepemimpinan formal. Praktik shadow state atas kuasa aktor informal yang mampu “menyetir” aktor struktural formal pemerintahan terejawantahkan pada kasus aktualisasi kebijakan publik dan politik kesehariannya di desa adat Guradog.
Dinamika Pengaruh Organisasi Masyarakat dalam Pengisian Anggota Komisi Pemilihan Umum di Daerah
Authors: Busthomi Masum , Satriawan M. Iwan
Published: July 2020

Pemilihan umum (pemilu) adalah suatu mekanisme yang berfungsi sebagai sarana pelaksanaan demokrasi yang sangat prinsipil. Dalam perjalanannya agar pemilu di Indonesia berjalan dengan baik maka dibentuklah KPU sebagai lembaga independen dan abadi yang mempunyai wewenang menyelenggarakan pemilu baik pilpres, pileg maupun pilkada. Untuk dapat menyelenggarakan pemilu, maka dipilihlah komisoner KPU dari unsur masyarakat melalui pembentukan tim seleksi (Timsel) yang independen.  Dalam pemilihan timsel ini juga tidak dapat terlepas dari unsur-unsur masyarakat seperti akademisi, tokoh masyarakat dan ahli pemilu. Penelitian ini merupakan penelitian kualitatif deskriptif dengan metode studi kasus. Fokus perhatian penulis diarahkan pada realitas sosial yang berlangsung terhadap objek yang diteliti sehingga penelitian ini memandang individu dan organisasi  sosial keagamaan sebagai bagian dari suatu kekuatan yang dapat menentukan terpilih atau tidaknya calon komisioner KPU. Hasil analisis menyatakan bahwa dalam praktikknya pemilihan komisioner KPU tidak hanya ditentukan oleh kemampuan personal namun juga dipengaruhi oleh ideologi ormas yang ada dalam tim seleksi tersebut. Sehingga komposisi jumlah timsel dari salah satu ormas akan berpengaruh terhadap jumlah keterpilihan calon komisioner KPU yang satu ideologi dengan salah satu ormas.
Whey Proteini İzolatının Rat Böbreğine Histolojik Etkileri
Authors: Kutlay Özden , Aslan Esra
Published: July 2020

Amaç: Whey proteini diğer yapısal proteinlere göre daha fazla miktarda dallı zincirli aminoasit içeren tam bir proteindir. Bu proteinin uzun süreli kullanımının böbrek dokusunda meydana getirdiği histolojik değişiklikler henüz araştırılmamıştır. Bu çalışmada düzenli olarak bir ay boyunca gavaj ile whey protein izolatı verilen ratların böbrek dokusundaki histolojik parametrelerin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntem: Bu çalışma Afyonkarahisar Sağlık Bilimleri Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı ve Histoloji ve Embriyoloji Anabilim Dalı’nda, 250-300 g ağırlığında 30 adet Wistar Albino erkek sıçan kullanılarak yapılmıştır. Her grupta 10’ar sıçan olacak şekilde kontrol, sham ve whey proteini uygulanan grup olarak 3 gruba ayrılmıştır. Kontrol grubuna herhangi bir uygulama yapılmazken, sham grubuna 1 mL çeşme suyu, whey proteini grubuna 6 g/kg/gün whey proteini 1 mL çeşme suyunda çözünerek bir ay boyunca gavajla verilmiştir. Böbrek dokusundaki genel morfolojik değişiklikleri incelemek için Hematoksilen-Eozin, PAS ve Masson-Trikrom boyamaları yapılmıştır. Böbreklerdeki IL-6, FGF-1, p53 ekspresyonlarını değerlendirmek için dokular immunohistokimyasal olarak boyanmıştır.

Bulgular: Whey protein grubunda hafif mezengial matriks genişlemeleri görülmekle beraber hem bu grupta hem de diğer gruplarda bunun dışında başka bir patolojiye rastlanmamıştır. Whey protein grubunda IL-6 ve FGF-1 boyanmaları diğer gruplara göre istatistiksel olarak anlamlı bir artış göstermiştir (p<0.05).

Sonuç: Whey proteini verilen sıçanların böbreklerinde histolojik ve morfolojik bir değişiklik görülmemiştir. Bununla beraber IL-6 ve FGF-1 ekspresyonlarının artmış düzeylerinin, fizyopatolojik deneysel hayvan modellemelerinde yol gösterici olması açısından önemlidir.
Recurrent Kidney Stones and Parathyroid Adenoma
Authors: Andrabi Syed Muzamil , Malik Ajaz Ahmad , Bhat Javaid Ahmad
Published: July 2020

A 29-year-old female presented to the out-patient Department of Surgery with history of recurrent kidney stones. Patient was on medical management for recurrent kidney stones for the last 5 years and even had undergone uretroscopic lithotripsy (URSL) for impacted left ureteric stone. Patient was evaluated in the past but no primary diagnosis was made. We evaluated and the patient was found to have hypercalcaemia (11.8 g/dl) with raised parathyroid hormone (PTH) levels.
HYPERDENSE BASILAR ARTERY – EARLY SIGN OF STROKE
Authors: Masood Mohammad , Kumar Akshit , Shah Omair Ashraf , Shaheen Feroz
Published: July 2020

Hyperdense artery sign is presumed to represent acute thrombus or clot, and is an early indicator of posterior circulation stroke. This sign if detected, in proper clinical scenario can help the clinician to detect the basilar occlusion and to intervene early. We are presenting a case of 30 yr. old female, normotensive, nondiabetic presented with sudden onset focal left sided seizure, central vertigo, diplopia and decreased vision in left eye to emergency department. On examination, ptosis and anisocoria, Left facial nerve palsy. Patient was advised NCCT Head, which showed hyperdense basilar artery , seen retrospectively after MRI.
Healthy lifestyle and life expectancy free of chronic diseases
Authors: Baba Peerzada Umar Farooq , Wani Adil Hafeez
Published: July 2020

The average life expectancy in the world has increased substantially in the past few decades. Modifiable lifestyle factors including smoking, physical activity, alcohol intake, body weight, and diet quality affect both total life expectancy and incidence of chronic diseases. Few studies have comprehensively examined how a combination of multiple lifestyle factors may relate to life expectancy free from major diseases such as diabetes, cardiovascular disease, and cancer. A Harvard team examined the effect of healthy lifestyle factors on life expectancy free of chronic diseases, using data from up to 34 years of follow-up in the Nurses’ Health Study (NHS) (1980-2014; n=73 196) and 28 years of follow-up in the Health Professions Follow-up Study (HPFS)(1986-2014;n=38 366). A healthy lifestyle score based on information on five lifestyle factors—diet, smoking, physical activity, alcohol consumption, and body mass index (BMI) was derived. Five low-risk lifestyle factors included: never smoking, body mass index 18.5-24.9, moderate to vigorous physical activity (≥30 minutes/day), moderate alcohol intake (women: 5-15 g/day; men 5-30 g/day), and a higher diet quality score (upper 40%). Women who met all the healthful lifestyle measures had an additional 10.7 years of disease-free life compared with women who met no healthful lifestyle measures. For men, the number was 7.6 additional disease-free years. So it was concluded that a healthier lifestyle was associated with an increased total life expectancy and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes. Findings suggest that the promotion of a healthy lifestyle would help to reduce healthcare burdens. Public policies for improving food and the physical environment conducive to adopting a healthy diet and lifestyle are critical to improving life expectancy, especially life expectancy free of major chronic diseases.
Source: BMJ 2020; 368:l6669 http://dx.doi.org/10.1136/bmj.l6669
Nutrition in Cancer –Practical Perspective
Authors: Wani Shaqul Qamar , Khan Talib , Khan Zaka Sameen , Najmi Arshad Manzoor , Malik Tariq Rasool , Ahmad Ishtiyaq , Lone Mohammad Maqbool , Afroz Fir , Khan Nazir Ahmad
Published: July 2020

The syndrome of Cancer cachexia is characterised by an involuntary, sustained loss of weight and skeletal muscle mass, which negatively affects patients’ evolution and their quality of life, increasing the incidence of infection, hospital stay and mortality. The proportion of patients who present weight loss at diagnosis varies between 15 and 40% and may go up to 70 % depending on the type, stage of cancer and disease course. Patients with tumours of the gastrointestinal tract, head and neck, liver and lung cancers are at high risk for malnutrition (de las Peñas R), (Arends).
Prospective Study of Gross and microscopic changes in 146 cases of Cryptorchid Testes at varied locations with particular reference to the incidence of Germ cell Tumors in Biopsy specimens.
Authors: Shiekh Mahmood Rashid , Sheera Tahleel , Rashid Sheikh Amir rashid , Hussain Shera Altaf , Hafiz Khan Ather
Published: July 2020

Cryptorchidism or undescended testes is a commonly observed congenital anomaly of male children seen in patients presenting in general and paediatric surgical practice of our region. Cryptorchid testes are observed unilaterally or bilaterally in one to ten per cent of male infants at birth1 and its incidence decreases to 0.8 per cent at the age of one year. Occasionally a truly cryptorchid testis descends spontaneously at puberty or in response to parental chorionic gonadotropin therapy , but this is not the rule and usually surgical exploration with orchidopexy or orchidectomy (in rare cases) is required. Cryptorchid testes are associated with varied pathological changes depending upon age at presentation, location of undescended testes and familial and genetic factors. In this study, we examined gross and microscopic changes in histological specimens of 146 patients operated in the department of General Surgery at Govt. Medical College Baramulla from Nov. 2014 to Dec. 2019 and concluded that most of the patients tend to present late for surgery especially in the rural settings of north Kashmir with consequent increased risks of malignancy and infertility.
Role of Glabellar flap in midfacial reconstruction.
Authors: Zargar Haroon Rashid , Mohsin Mir , Bhat Hilal Ahmed , Shah Raheeb Ahmed , Bashir Sheikh Adil , Rasool Altaf , Baba Peerzada Umar Farooq , Bijli Akram Hussain , Wani Adil Hafeez
Published: July 2020

Aims: Reconstruction of midface always poses a challenge to a Plastic surgeon as one has to address the convexities and concavities which are somewhat unique to this area. Various local flaps have been used for achieving these goals. This study was conducted to evaluate the indications, feasibility and outcome of midfacial reconstruction using Glabellar flaps at a tertiary care center.

Materials and Methods: This is a prospective observational study conducted in the Department of Plastic and Reconstructive Surgery of a tertiary care hospital between January 2016 to December 2019. All the patients who underwent midfacial reconstruction with Glabellar flaps during this period and consented to be a part of this study were included. Patient demographics, wound etiology and area, flap size and its mode of transfer, number of surgeries required, type of anesthesia used, comorbid conditions, complications if any and the results of reconstruction were recorded. All the patients were followed up till May 2020.

Results: Thirteen patients were managed with Glabellar flaps. Majority of the patients (n=9, 69.23%) were males, with a mean age of 34 years. Most common cause of wounds was animal bite/maul (n=5, 38.46%). Glabellar flap was most commonly used as V-Y rotation advancement flap in nine patients (69.23%). Most of the cases (n=9, 69.23%) was operated under local anesthesia. Donor site was closed primarily in V-Y or linear fashion in 12 cases, and skin grafted only in 1 case. Majority (n=12, 92.3%) of the patients graded reconstruction results as Good-Excellent.

Conclusions: Glabellar flap is an excellent option for reconstruction of midfacial defects with minimal donor site morbidity and can be performed safely under local anesthesia.
Hepatitis C Virus Infection
Authors: Wani Nissar Ahmad
Published: July 2020

Hepatitis C Virus Infection                                                                 

I have read with great interest the review entitled “Hepatitis C Virus Infection: A Brief Review” recently published by Saleem Kamili and Hisham Qadri in JMS, SKIMS (Vol 23 No 1 (2020): Jan-Mar).Useful information has been presented and these efforts will definitely help the clinicians to treat Hepatitis C patients in a better and effective way. I wish to make the following comments on the diagnostic evaluation of Hepatitis C infection. This was need of an hour to know the prevalence, causes, symptoms and available treatment of this disorder. As we know the virus can cause both acute and chronic hepatitis, ranging in severity from a mild illness lasting a few weeks to a serious, lifelong illness. New HCV infections are usually asymptomatic. Some persons get acute hepatitis which does not lead to a life-threatening disease. It is important to note here that around 30% (15–45%) of infected persons spontaneously clear the virus within 6 months of infection without any treatment. The remaining 70% (55–85%) of persons will develop chronic HCV infection. Of those with chronic HCV infection, the risk of cirrhosis ranges between 15% and 30% within 20 years. Globally, an estimated 71 million people have chronic hepatitis C virus infection. WHO estimated that in 2016, approximately 399 000 people died from hepatitis C, mostly from cirrhosis and hepatocellular carcinoma primary liver cancer).Antiviral medicines can cure more than 95% of persons with hepatitis C infection, thereby reducing the risk of death from cirrhosis and liver cancer, but access to diagnosis and treatment is low.
Tissue acquisition for diagnosis of proximal biliary lesions using endoscopic ultrasound-guided fine-needle aspiration.
Authors: Singla Vikas , Daswani Ravi , Arora Anil , Verma Kusum , Kumar Mandhir , Ranjan Piyush , Puri Pankaj , Kumar Ashish , Bakshi Pooja , Bansal Naresh , Sachdeva Munish Kumar , Sharma Praveen , Anikhindi Shrihari Anil , Agarwal Rachit , Khare Shivam
Published: July 2020

Objectives: To report the diagnostic yield and safety of endoscopic ultrasound-guided fine-needle aspiration (EUS FNA) for the evaluation of proximal bile duct lesions.

Materials and methods: A retrospective analysis of data of the patients, who had undergone EUS for proximal bile duct lesions was done. FNA was performed from either the bile duct mass, enlarged node, or liver lesions. Outcome measures were the diagnostic yield of EUS FNA and adverse events.

Results: From April 2011 to August 2018, 147 patients with suspected proximal bile duct malignancy underwent EUS. Mass lesion was seen in 133 (90.47%) patients. FNA was performed in 125 (85.03%) patients. The final diagnosis in patients undergoing EUS FNA was malignancy in 118, benign disease in six, and one patient was lost to follow up. EUS FNA confirmed the diagnosis in 103/118 patients with malignancy (sensitivity 87.28%); was false negative in 15/118 cases with malignancy, and was truly negative in all the six patients with benign disease (specificity 100%). Positive predictive value, negative predictive value, and the accuracy of EUS FNA were 100%, 28.57%, 87.90% respectively. No serious adverse event was reported, five patients had self-limiting pain.

Conclusion: EUS FNA is a sensitive tool for the evaluation of proximal bile duct lesions. Low negative predictive value warrants further evaluation in patients with non-malignant findings on cytology.
Laboratory diagnosis of SARS-CoV-2: an Update for Clinicians
Authors: Bhat Imtiyaz Ahmad , Shah Zafar Amin , Masoodi Shariq R
Published: July 2020

SARS-CoV-2 belongs to the genera Beta coronavirus with a spherical or pleomorphic virus enveloped particles. The SARS-CoV-2 has sequence homology with severe acute respiratory syndrome-related coronaviruses (SARSr-CoV) and acts on ACE2 (Angiotensin Converting Enzyme 2) receptor by using its spike proteins. The latter are primed by the enzyme, TMPRSS2 protease to complete this process for its entry into the cells [1-3]. The SARSr-CoV has a single-stranded positive-sense ribonucleic acid (RNA) as a genomic material associated with a nucleoprotein within a capsid comprised of matrix proteins. The envelope bears a club-shaped glycoprotein projection containing haemagglutinin-esterase proteins (HE) also. The size of Coronaviruses genome is around (26.4-31.7Kb), which is one of the largest genomes in RNA known viruses and bears the GC content of approximately 32 to 43%. The viral genome contains distinctive features including a unique N terminal fragment within the spike proteins. The genome contains a variable number of ORF (6–11) between the various conserved genes (ORF1ab, spike, envelope, membrane and nucleocapsid [4]. Two third of the SARS-CoV-2 viral RNA is located in the ORF (ORF1a/b) and synthesise polypeptides pp1a and pp1a, and 16 non-structural proteins (NSP) are encoded by these ORFs, and the remaining accessory proteins are translated by other ORFs. The genome that encodes essential structural proteins which are important in the pathogenicity of SARS-CoV-2 like spike (S) glycoprotein, small envelope (E) protein, matrix (M) protein, and nucleocapsid (N) protein are translated by the rest of the viral genome [5].
ANALISIS KUALITAS PELAYANAN PUBLIK DI KANTOR DESA REDANG KECAMATAN RENGAT BARAT KABUPATEN INDRAGIRI HULU
Authors: Putra Muhklas Adi , Dewi Kurnia
Published: July 2020

The government as a public sector institution carries out and provides public services which are vital for the public interest. This study aims to determine the Quality of Public Services at the Redang Village Office in West Rengat District, Indragiri Hulu Regency. This research used qualitative descriptive analysis, and to collect all the data this research used interviews, observation and documentation. The results of this study indicate that in general the quality of public services in the Redang Village Office in West Rengat District, Indragiri Hulu Regency is seen from five indicators are: Tangibles (real evidence), Reliability, Resposiveness, Assurance, and Empaty (empathy) is still lacking in quality. Likewise, the Redang Village apparatus must further improve the quality of its services by increasing the ability and motivation and discipline.
PENGARUH GAYA KEPEMIMPINAN DAN IKLIM ORGANISASI TERHADAP KINERJA KARYAWAN PADA PT. TIRTA SARI KABUPATEN INDRAGIRI HULU
Authors: Saputra Marwan Indra
Published: July 2020

This research was conducted on PT. Tirta Sari Indragiri Hulu Regency with the aim to determine the influence of Leadership Style and Organizational Climate variables on Employee Performance at PT. Tirta Sari, Indragiri Hulu Regency. Sampling was done by accidental sampling method with 146 samples as respondents. The analytical method used is quantitative descriptive, data analysis is carried out simultaneously (multiple linear regression analysis with the help of IBM SPSS Stastic version 21.0. From the results of the study, the regression equation obtained is Y = 6.313 + 0.143X1 + 0.242X2, it can be seen that the Leadership Style and Organizational Climate have a positive influence on Employee Performance at PT. Tirta Sari, Indragiri Hulu Regency. In addition, simultaneous testing (Test F), has obtained F count > F table that is equal to 8.738 > 3.06. So that the two independent variables namely Leadership Style and Organizational Climate together have a positive and significant effect on the dependent variable, namely Employee Performance at PT. Tirta Sari, Indragiri Hulu Regency. While the Partial Regression Test (t test) shows that the dominant Climate Organization variable has a significant effect on Employee Performance at PT. Tirta Sari, Indragiri Hulu Regency, which is t count> t table of 3.394> 1.97658. While the leadership style variable has a significant effect on employee performance at PT. Tirta Sari, Indragiri Hulu Regency, which is t count > t table of 2.037 > 1.97658. In addition, the result of the multiple correlation coefficient is 0.330 which shows the level of the relationship between all independent variables to the dependent variable in this study is in the criteria of the weak relationship. The amount of influence caused by these two variables together affects the variable Employee Performance with a percentage of 10.9%. While 89.1% was influenced by other factors that did not participate in this study.
THE INFLUENCE OF ACTIVITY PLANNING, FUND WITHDRAWAL PLANNING AND ACCURACY ON BUDGET REALIZATION USING FORECASTING IN THE NON VERTICAL SPECIFIC WORKING UNITS OF WATER UTILIZATION NETWORK IMPLEMENTATION OF MESUJI SEKAMPUNG IN 2014-2016
Authors: Hairudin Hairudin , Nurhartanto Adhi , Hasbullah Hasbullah
Published: July 2020

The purpose of this research is to examine and determine the effect of activity planning, fund withdrawals and accuracy of budget realization in certain non-vertical work units in the implementation of mesuji water use networks in the 2014-2016 period. This research uses descriptive and quantitative methods from the results of financial statements for 3 years with 1 company. By using the classic assumption test, multiple linear regression analysis, and hypothesis testing. The results of multiple regression analysis with Y = -22,513 + 1,741 (X1) + 0,172 (X2) + 0,071 (X3) + e indicate that the variable planning activities and withdrawing funds together have a significant effect on budget realization.
THE ANALYSIS OF MARKET SERVICE AND TOURIST ATTRACTION OBJECT PROMOTION IN RENGAT INDRAGIRI HULU DISTRICT
Authors: Warnadi Warnadi , Putra Muhklas Adi
Published: July 2020

Tourism is one of the sectors that the government relies on to earn foreign exchange from non-oil and gas income. The impact of tourism development on economic development is so large that special attention is needed. The problem in tourism objects in Rengat Subdistrict, Indragiri Hulu Regency which is the main focus in this research is the lack of marketing services to a weak service system and the promotion of attractions that are still felt to be lacking. The results of this study indicate that market opportunity analysis will determine the next step, namely the determination of strategic service concepts that are translated into market positioning and implemented in the service marketing concept. And Indragiri Hulu Regency which actually has been supported by natural conditions and potential tourism environment. Promotional mix is ​​one component of the marketing mix that plays an important role in the process of achieving the expected goals, namely to introduce, inform, persuade and influence prospective tourists to visit and keep tourists always remembering and desiring to make a return visit to Rengat City with tourism objects which exists.
THE EFFECT OF ECONOMIC GROWTH AND THE NUMBER OF POPULATION TO THE UNEMPLOYMENT RATE IN INDRAGIRI HULU REGENCY
Authors: Triyono Aris
Published: July 2020

The research location used as the object of this research is the Central Statistics Agency of Indragiri Hulu Regency. This study aims to determine the effect of economic growth and population simultaneously on the unemployment rate, to determine the effect of economic growth partially on the unemployment rate, to determine the effect of the total population partially on the unemployment rate in Indragiri Hulu Regency. The type of data used in this study is secondary data. The analytical method used is multiple linear regression methods, with the help of SPSS version 21.

Based on the results of simultaneous economic growth and population growth has a significant effect on the unemployment rate, economic growth has a partially positive and significant effect on the unemployment rate, the population has a partially positive and significant effect on the unemployment rate, and other variables affect the unemployment rate that is not examined in research
Hereditary inclusion body myopathy: a clinical and genetic review
Authors: Sgobbi de Souza Paulo Victor , Badia Bruno de Mattos Lombardi , Gonçalves Eduardo Augusto , Farias Igor Braga , Bocca Vieira de Rezende Pinto Wladimir , Souza Bulle Oliveira Acary
Published: July 2020

Introduction. Inclusion body myositis represents the most common acquired myopathy in clinical practice in patients over 50 years old. Despite classical approach to this myopathy as an inflammatory disorder, a muscle degenerative disorder is now considered the main mechanism linked to these vacuolar myopathies. Hereditary presentations, although quite rare, represent an expanding and underrecognized group in clinical practice. Objective. perform a structured review of the current literature regarding hereditary inclusion body myopathies. Method. review of U.S. NLM PubMed and MEDLINE database of original articles, case reports, case series and review articles including the terms “inclusion body myositis” OR “inclusion body myopathy” AND “genetics” OR “hereditary”. Results. We present in this article a wide review regarding the main clinical, imaging, pathophysiological, genetic and therapeutic aspects related to hereditary myopathies linked to seven different clinical and genetic presentations (GNE, MATR3, VCP, SQSTM1, MYH2, HNRNPA2B1 and HNRNPA1). Conclusion. Hereditary inclusion body myopathy is associated with at least 7 distinct clinic and genetic monogenic forms.
2D Material-based Quantum Logic Gate Operating Via Self-Organization of Quantum Dots
Authors: Voronov V.K. , Dudareva O. V. , Gerashchenko L.A.
Published: July 2020

In the paper, nanotrigger-based electronic device, capable of performing the quantum computation procedure, is described. The device represents a quantum logic gate formed from a two-dimensional material and controlled by a quantum dot. The operation of the quantum dot is analyzed. In the model representation, the transition between two states of the quantum dot, each of which controls the flow of the nanotransistor current (one of the shoulders of the nanotrigger), is equivalent to tunneling through an energy barrier separating the states. Fundamentally important is the fact that in one of these states the quantum dot is diamagnetic, and in the other it is paramagnetic. The paramagnetism of the quantum dot is due to the electronic exchange interaction, characteristic of the systems with unpaired electrons. Thus, the elementary self-organized 2D-material-derived logic gate disclosed in the present work can be employed for design of an electronic reversible unit.In other words, such a unit is able to prepare and to trigger the computation procedure.
Static Mantle Density Distribution 3 Dimpling and Bucking of Spherical Crust
Authors: Yun Tian-Quan
Published: July 2020

This paper is the third step of project “Static mantle distribution, Equation, Solution and Application”. It consists of < Static Mantle Distribution 1 Equation>, , and this paper. Our result on shape of core is a “X type”, which differs from the traditional view that core is a sphere. Which one is correct? or, both are not correct? The aim of thispaper is to study dimpling and bucking of the spherical crust under mantle loading. Dimpling analysis depends on the outer solution of non-homogeneous non-linear D.E., while bucking analysis depends on non-linear Eigen value of the homogeneous D. E The results based on two models and governing equations show that crust dimpled at poles is proved theoretically and numerical result well consists with pole radius, while the non-linear bucking Eigen value boundary problem is solved by decomposition method. The results show that bucking can occur, and the un-continuity of internal force per unit length causes un-continuity of masses by mantle material emitting to crust at turning point of “X”. The growing of Tibet high-land might be viewed as an evidence of the mass ms(θ0)increasing due to mantle emission. Both poles radius and equatorial radius have been used to support our analysis. Question: how the nature makes cold at poles?