bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitigating factors of screen time on children: a systematic review
Authors: Sharma Harshita , Ahuja Sona
Published: October 2024

Screen time is a modern dilemma that has unplugged children from Mother Nature. It is a time that the child spends using technologically driven devices such as television, smartphones, computers, gaming consoles, etc. For children, this shift is profound as they grow up in an immersed digital era that has lasting effects on their development and well-being. This systematic review aims to identify the intervention strategies for lessening screen exposure and finding mitigating factors of screen time for young children aged 4 to 12 years old. Screen time-related studies were searched in two databases PubMed and EMBASE. The keywords of “screen time”, “television”, “video”, “computer”, “mobile device”, “children”, “interventions”, and “strategies” used for search. The inclusion criteria are limited to specific study populations, intervention, comparison, and outcomes (PICOs), language, and published study types. The quality of articles was assessed using the Cochrane Risk of Bias (RoB) tool. Two researchers independently screened the literature and extracted the data. Seven eligible studies were included out of a total of four hundred and eighteen studies. The study sample ranges in the age range of (4-12 years) and the size ranges from (75 children and 39 parents to 709 children and 64 parents) participants. In included studies (randomized controlled trials), we found seven mitigating factors of screen time usage.  It showed that in addition to educating people about the dangers of excessive screen time, effective programs, implementing restrictive practices, and providing a healthy home environment were the most common strategies used by the researchers. Future screen time reduction studies could benefit from incorporating more emphasis on implementing interventions like structured screen time, school involvement, health education, and more awareness programs to mitigate screen time among children.
Incontinentia pigmenti: a rare cause of skin rash in newborn
Authors: Bajaj Upasana , Bhattacharjee Prasun , Mishra Keeranmayee , Trivedi Pranay , Parashar Ashwani
Published: October 2024

Incontinentia pigmenti (IP) is a genodermatosis caused by mutations in the NEMO gene (Xq28) and is lethal in males. It is an X-linked dominant disorder with multi-systemic involvement. It involves the central nervous system and ectodermal tissues like skin, teeth, hair, nails, eyes, and the commonest manifestations are cutaneous manifestations. Here we present a case of a female newborn with vesico bullous eruption presented at birth. A full-term newborn female patient born by LSCS presented at birth with multiple vesico bullous skin lesions over bilateral upper and lower limbs in a pattern consistent with Blaschko's lines. Maternal HIV, HBsAg, VDRL, and TORCH screening were negative. Systemic examinations were normal. Supportive care and IV antibiotics with IV acyclovir were started but without any response. The sepsis screen, blood, and urine culture were negative. ANA was negative. Wound swab culture and skin culture were negative. Skin biopsy results showed eosinophilic infiltration of the dermis and spongiosis. Genetic testing could not be done. Topical steroids were prescribed. The diagnosis of Incontinentia pigmenti was established based on the patient's skin lesions and biopsy results. The baby improved and was discharged on the 14th day of life on topical steroids and is currently under follow-up. Other dermatologic conditions, like mastocytosis and hereditary epidermolysis bullosa, should be considered in the differential diagnosis of Incontinentia pigmenti. The diagnosis of Incontinentia pigmenti should be confirmed by histopathological examination of biopsy specimens along with genetic testing. It is a systemic disorder, so clinical management should include a multidisciplinary approach.
A strange cause of nasal blockage and anemia in an infant
Authors: Thakur Rashika , Sharma Yash Pal , Sharma Shruti
Published: October 2024

Leeches are sanguivorous parasites causing infestation in humans and other warm-blooded mammals, mainly affecting older children and adults with most common site of attachment being nasopharynx. We present a case of severe anaemia and growth failure in an eight-month-old infant due to nasopharyngeal leech infestation with symptoms of nasal blockade and blood-tinged nasal exudation. The child showed significant improvement on follow-up after removal of the leech.
Subgaleal hematoma in hereditary coagulopathy haemophilia B: a case report
Authors: Arora Vivek , Sharma Kapil , Sharma Akanksha , Joshi Mahima
Published: October 2024

Subgaleal haemorrhage, characterized by blood accumulation in the subgaleal space, can lead to significant blood loss and shock, often exacerbated by hereditary coagulopathies like haemophilia. A full-term male neonate, born at 39 weeks via spontaneous vaginal delivery, presented 12 hours post-birth with temporal swelling, periorbital edema, and raccoon eyes. Examination showed increased head circumference, severe anaemia, and elevated aPTT. Imaging confirmed subgaleal hematoma. The infant received packed red blood cells, fresh frozen plasma, factor IX, IV fluids, antibiotics, and phototherapy.
Impactos do Trabalho Remoto na Qualidade Vocal e na Comunicação Oral de Professores de Canto Durante a Pandemia da COVID-19
Authors: Vieira Jéssica Rafael , Lamego Caio Roberto Siqueira , Coelho Cristiane Magacho , Pereira Tiago Rosa
Published: October 2024

A pandemia da COVID-19, fez com que, em 2020, se iniciassem diversas medidas de distanciamento e isolamento social para combater o avanço da doença. Repentinamente, professores tiveram que se adaptar ao ensino online e aprender a utilizar diferentes ferramentas tecnológicas para poder dar continuidade ao processo de ensino dos seus alunos, enfrentando grandes desafios. O tema deste projeto foi motivado pelo pensamento de que o ensino do canto vai além da docência tradicional. Ele se mistura com aspectos subjetivos da arte e da música e possui uma pedagogia própria. Diante de tal complexidade, este artigo tem como objetivo relatar os achados da investigação de quais foram os impactos gerados aos professores de canto, inclusive os impactos na qualidade vocal e na comunicação oral causados pela modalidade de trabalho remoto imposta pela COVID-19.
 
Palavras-chave: COVID-19. Fonoaudiologia. Voz. Aula remota. Professor de canto.
AN AGREEMENT WITH COUNTER-OBLIGATIONS IN THE INVESTMENT SPHERE
Authors:   Associate Professor of the Department of Civil Law of the Kazan Branch of the Russian State University of Justice, Kovalkova Elena Yu.
Published: October 2024

The article considers a contract with counter investment obligations (offset contract) as a means of implementing state and municipal needs and a mechanism that allows attracting investments to the regions. The concept and features of a contract with counter investment obligations, enshrined in the legislation on the contract system in the field of procurement of goods, works, services for state and municipal needs, are analyzed, the content of a contract with counter investment obligations (offset contract) is analyzed.
GREEN ECONOMICS WITHIN THE FRAMEWORK OF INTERNATIONAL INVESTMENT AGREEMENTS
Authors:   ssociate Professor of the S.N. Lebedev Department of Private International and Civil Law, Popov Evgeny V.
Published: October 2024

The matters of green economics within the framework of the environmental transformation of the energy sphere (the energy transition), reduction of the anthropogenic impact on the environment in the course of socioeconomic development, give investment opportunities for international business but at the same time pose specific systemic and structural challenges to investors, states that receive investments, researches and individuals that witness the consequences of the dynamic change of the environment in the contemporary conditions. The presented article studies the evolution of approaches to international law regulation of investment activities from the standpoint of solution of environmental protection and conservation tasks in order to analyze opportunities with regards to the named challenges. Such analysis is used as a basis to conclude that the historical and legal method of studying the problems in question gives an opportunity for a systemic and structural evaluation of the original prerequisites for the logic of development of the international law architecture of regulation of investment activities in respect of goals and tasks of publicly significant environmental protection and conservation interests including the sphere of green economics and minimization of negative consequences of the anthropogenic impact as a result of investment activities, and evaluate the logic and limits of application of international investment agreements to achieve the environmental protection and conservation goals.
APPLICATION OF THE ECOSYSTEM APPROACH TO LIQUIDATION AND COMPENSATION OF ACCUMULATED DAMAGE TO THE ENVIRONMENT
Authors:   Postgraduate Student Professor of the Department of Land and Environmental Law, Kudyakov Aleksandr K.
Published: October 2024

The process of formation and recognition of responsibility for accumulated environmental damage is considered. The possibilities of applying the ecosystem approach to the legal regulation of organizing the elimination of accumulated environmental harm are explored, including assessing the results of the restoration measures taken and the formation of criteria for recognizing objects of accumulated harm as liquidated. A justification is given for the need to apply an ecosystem approach to eliminating accumulated environmental damage in order to achieve the goal of rational environmental management (restoring and increasing the sustainability of natural ecological systems and ensuring their equilibrium state).
SPECIAL ASPECTS OF BANKRUPTCY OF MANAGEMENT COMPANIES: LEGAL REGULATION AND LAW ENFORCEMENT
Authors:   Associate Professor of the Department of Civil Law of the Rostov State University of Economic (RSUE), Toporov Dmitry A.
Published: October 2024

The article provides a comprehensive analysis of legal aspects related to debt management for communal services and bankruptcy procedures of managing companies in the Russian Federation. The main focus is on analyzing the heterogeneity of legal approaches in judicial practice, obligations and rights of subscribers for payment of communal services, as well as recent changes in legislation aimed at increasing transparency in the housing and communal services sector and strengthening the rights of property owners. The author proposes comprehensive measures to improve the situation, including the standardization of legal approaches, strengthening control over payment for services, and preventing bankruptcy of managing companies through the development of effective mechanisms.
RIDESHARING: PROBLEMS OF LEGAL REGULATION IN RUSSIA
Authors:   Postgraduate Student of the Department of Civil Law of the Saratov State Law Academy, Skuchaev Andrey A.
Published: October 2024

Ridesharing is the joint movement of several individuals in a single vehicle along a route defined by the vehicle owner. From a legal point of view, this agreement can be regarded as an unnamed joint travel contract. The development of ridesharing is facilitated by the widespread use of smartphones and platforms providing digital services. The main purpose of ridesharing is to save financial resources and to improve the environment by reducing the number of cars on the road. The transport legislation of a number of countries has introduced norms on the legal regulation of shared travel. In the Russian Federation it is necessary to clarify the regulatory framework in this area, as the lack of legal regulation leads to abuse of the right. The purpose of this study is to assess the possibility of legitimisation of ridesharing, to analyse the draft law developed by the Ministry of Transport of the Russian Federation on amendments to the Statute of Road Transport concerning the legal regulation of joint travel, to propose legal measures. The author has developed proposals on the definition of joint travel and ridesharing agreement, defined the legal nature of the agreement, reflected the positive and negative sides of the use of joint travel, analysed foreign experience of their legal regulation.
Specifics of Inheriting by Children Conceived and Born a Result of Posthumous Reproduction Programs Implementation
Authors:   PhD. Degree-Seeking Student of the Russian State Academy of Intellectual Property, Burmistrova Ekaterina V.
Published: October 2024

The practical application of posthumous reproductive programs, in which the conception and birth of a child (children) occurs after the death of the parents or one of them, has led to the possibility of new potential heirs appearing some time after the death of the testator (potential parent or potential parents). In this article, the author examines the legal status of "postmortem" children, both in domestic and foreign inheritance law. Based on the analysis of the norms of current domestic and foreign legislation, the author concludes that it is necessary to improve the current Russian legislation in the field of inheritance rights in the implementation of posthumous reproduction.
NFT Technologies in the Real Estate Investment Sphere: A Fad or the Future That Has Come
Authors:   Senior Lecturer of the S.N. Lebedev Department of Private International and Civil Law of the Moscow State Institute, Scherbakov Aleksandr A.
Published: October 2024

The work addresses an important and promising issue of using blockchain technologies to expand investment opportunities in real estate, enhance its liquidity, and increase the security of investments. To achieve this, two approaches are proposed: restructuring the real estate registration system based on blockchain technologies and utilizing real estate securitization.
Sovereignty and Promotion of the Human Factor in the System of Unity of Public Authorities
Authors:   Professor of the Department of Constitutional and Municipal Law of the Law Faculty of the Lomonosov Moscow State University, Timofeev Nikolay S.
Published: October 2024

The author examines the problems of popular and state sovereignty that determine the democratic essence of the Russian Federation and ensure social and state stability. The modern development of the Russian state presupposes a fair social structure, determined by the active role of the people based on the implementation of the principle of popular sovereignty. State sovereignty is not a principle — a privilege, but a duty of the state to ensure guarantees of the rights of its citizens. The popular character of Russian statehood is determined not by “transferred democracy” — “participation in elections”, but by the embodiment of the idea of a state based on the implementation of popular sovereignty. At the same time, attention is focused on the need to move from the bottom up — from small politics at the municipal level to big politics of the state as a whole.
Legal Framework and Prospects of Use of Digital Financial Assets and Digital Currency in Cross-Border Transactions
Authors:   Associate Professor of the Department of International and Public Law of the Law Faculty, Deputy Head of the Council of Young Scientists of the Financial University under the Government of the Russian Federation, PhD (Law), Ismailov Ismail Sh.
Published: October 2024

The article is devoted to the study of prospects for the use of digital financial assets, digital currency, as well as the digital ruble in cross-border operations, which could be considered as counter-sanctions measure. Special attention is paid to the adopted and pending amendments to legislation related to the use of digital assets and currencies in crossborder transactions, author analyzes possible models and mechanisms for conducting such transactions and the necessary infrastructural, economic and legal conditions for its implementation.
Regional Development: Theories and Schools
Authors:   Postgraduate Student of the Department of Economics and Management of the Kosygin State University of Russia, Kochetov Sergey S.
Published: October 2024

In this article, the author examines the regional development of the most powerful scientific schools that have developed in Europe, the USA, and the former USSR.
Ensuring the Sovereignty of the Russian Federation in the Information Sphere
Authors:   Leading Research Scientist of the Department of Information Security of the Financial University under the Government of the Russian Federation, Zharova Anna K.
Published: October 2024

Sovereignty is the main feature of the state, which determines the right of the bearer of supreme state power to independently, independently form, and also to exercise his will, including in the information sphere. We can notice that such concepts as technological sovereignty and digital sovereignty are used in regulatory legal acts. In this case, the logical question is how these concepts relate, and what role they play in ensuring sovereignty in the information sphere. The article analyzes the concepts of technological sovereignty and digital sovereignty as components of state sovereignty in the information sphere.
A Model of Organizing Police Activities Aimed at Assistance of Minors in the Republic of Crimea
Authors:   Head of the Department of Administrative Law and Administrative Activities of Internal Affairs Agencies of the Crimean Branch of the Krasnodar University, Chelpanova Marina M. , Sokolov Valery A. ,   Deputy Head of the Department of Administrative Law of the Rostov Law Institute of the Ministry of Internal Affairs of the Russian Federation
Published: October 2024

Assisting parents in correct upbringing of children, development of prosocial moral norms and principles is critical, an important function is undoubtedly played by social workers, teachers and psychologists. In the article, the author reviews special aspects of assistance of minors in the Republic of Crimea by police, areas of improvement of such activities along with some aspects of foreign experience of assistance of minors by police.
Relevant Legal, Organizational and Program Areas of Improvement of Activities of Avantguard Training Centers
Authors:   Member of the Expert Advisory Board of the Committee on Constitutional Legislation and State- Building of the Federation Council of the Federal Assembly of the Russian Federation, Vavilin Mikhail V.
Published: October 2024

The article presents the results of scientific analytical work on the study of the formation of educational and methodological centers ʻAvangardʼ in the Russian Federation. It seems that in the further development of the system of these centers of military-patriotic education and training, the main role is played by improving the regulatory framework. The directions proposed in the article for improving the activities of the centers will make it possible to centralize this system, increase the effectiveness of the applied methods of training and management of the material base of the centers. As a vector for further research, it is worth turning to the spatial and territorial organization of the system of these centers, but this will be discussed in the following publications.
The Factor of Ethnic Anclavization in the Field of Migration and Its Relationship with Naturalization in Modern Russia (Based on Materials of a Specific Sociological Study)
Authors:   Professor of the Department of Constitutional and Municipal Law of the Kikot Moscow University of the Ministry of Internal Affairs of Russia, Chervonyuk Vladimir I.
Published: October 2024

The article, based on a specific sociological survey conducted by the author, presents an analysis of the theoretically unexplored and practically significant problem of the ethnosocial component of modern immigration in the Russian Federation, which has a significant impact on the steadily formed asymmetry in the field of naturalization, as a result of which there are real risks of loss or significant weakening of national identity, changes in the balance of the ethnic composition of the country's population and changes in its the socio-cultural environment.
ACCUSATION IN THE JUSTICE OF THE PEACE COURT: TYPES AND PROCEDURE
Authors:   Professor of the Department of Criminal Law, Criminal Procedure and Criminalistics of the Moscow State Institute of International Relations (University), Grinenko Aleksandr V.
Published: October 2024

The article is devoted to the study of the concept and types of accusation and special aspects of the accusatory procedure in criminal case proceedings in the justice of the peace court. Special attention is paid to protection of rights of an individual at various stages of judicial proceedings in privately prosecuted, privately and publicly prosecuted, publicly prosecuted criminal cases. The author suggests efficient algorithms in activities of a justice of the peace and justifies amendments and supplements to the applicable laws.
Legal Regulation of Good-Faith Practices in Entrepreneurship
Authors:   Associate Professor of the Department of Private Law Disciplines of the Institute of Legislation and Comparative Law, Antonova Elena G.
Published: October 2024

The article deals with the peculiarities of legal regulation of fair practices in the course of entrepreneurial activity. According to the author, the maintenance of the system of fair practices is aimed at resolving the most complex issues of interaction between entrepreneurs and other participants of entrepreneurial activity. In the conditions of the modern market fair practices are considered in the context of the general problem of civil liability and sustainable business development. These problems are studied as a structural element of corporative social responsibility of business.
Apuntes sobre “Filosofía Analítica: ¿Qué es y por qué uno debería involucrarse?”
Authors: Fonseca Martínez Miguel
Published: October 2024

El profesor Follesdal comprende dos escuelas fundamentales en la filosofía contemporánea. De un lado la filosofía analítica, y aquello que puede ser denominado como filosofía continental. Sobre la primera afirma a su vez dos tradiciones que la conforman. Por un lado una corriente inspirada en la lógica, con génesis en Bolzano, Frege y Russell, y otra guiada en la dirección del análisis del lenguaje ordinario bajo la tutela del pensamiento de Moore, Austin y el segundo Wittgenstein.
¿Acaso hay algo en la nevera? Sobre la especificidad de la filosofía latinoamericana
Authors: Fonseca Martínez Miguel
Published: October 2024

La filosofía latinoamericana se ha enfrentado al espejo. En la cultura griega la filosofía logró cierta unidad comprendiendo su existencia y autenticidad como un problema de ella misma. La filosofía requiere un ejercicio de auto fundamentación que comprenda la importancia de la pregunta por la filosofía en el marco de un responder igualmente filosófico . Latinoamérica se ha enfrentado de forma análoga al problema de la existencia, autenticidad, validez y comportamiento de la filosofía. En este sentido, es concomitante a la formulación de la pregunta, cierto tipo de camino a seguir en el intento de respuesta, es decir, cierto tipo de metodología u horizonte desde el cual se encara el problema. ¿Existe una filosofía en América? Tal pregunta asecha las mentes incautas con un fastuoso atuendo. Sin embargo, si se reemplazan los términos para tenderle un ardid y revelar su forma, podríamos decir sin temor: “¿Es el caso que existe algo en la nevera?”.
Guía e instrumentos para el desarrollo de estudios de caso desde la política educativa
Authors: Bolívar Castañeda Cindy Cristina
Published: October 2024

El presente documento es una guía de trabajo que entrega una ruta metodológica para articular los marcos normativos de la política educativa nacional, a la resolución de casos frecuentes de la realidad escolar. Se constituye en un insumo didáctico que puede usarse en facultades de educación, específicamente en cursos de política educativa o afines. Cabe recordar que el estudio de la legislación educativa les permite a los docentes en formación, tener una mayor comprensión de los contextos educativos, participar en las discusiones epistémicas sobre la implementación de la política en las diversas realidades sociales y configurar una postura crítica y propositiva del rol docente en Colombia, a la luz de los acuerdos nacionales e internacionales que se desarrollan en el marco de un nuevo ordenamiento mundial.
Development and Prospect of Safe Coal Mining Technol- ogy Under Coal Mine Water Body in China
Authors: Xing Songzhan
Published: October 2024

This paper first briefly introduces the technology of safe coal mining under the water body, and then analyzes the development of the theory and method of the safe coal mining technology under the water body of coal mine. Then, the new progress of safe coal mining technology practice in underwater coal mines is proposed, and finally the development prospect of underwater coal mining technology is pro- posed, hoping to provide reference for relevant personnel.
Research and Limitations on Second Language Multi
Text Reading Comprehension
Authors: Han Yuehua
Published: October 2024

This article explores the importance and challenges of multi text reading comprehension in second language learning in the context
of globalization. Multi text reading comprehension requires readers to possess skills such as information integration, reasoning, and discrimination, which are significantly related to knowledge validation beliefs. The study analyzed the impact of cognitive beliefs, reading strategies,
prior knowledge, and emotional investment on multi text reading comprehension, and proposed strategies to enhance second language multi
text reading comprehension. Finally, this article points out the limitations of current research and proposes future research directions.
Interdisciplinary approach of odontogenic infectious foci – a literature review
Authors: Cabon Julia , Ziaja Karolina , Zawilska Anna , Trzcionka Agata
Published: October 2024

Ogniska zębopochodnego zakażenia to bakteryjne zmiany zapalne, których pierwotny ośrodek zlokalizowany jest w okolicy zęba przyczynowego. Za pośrednictwem różnych mechanizmów powodują powstawanie narządowych ognisk wtórnych lub infekcji ogólnoustrojowych. Rzetelna diagnostyka i eliminacja wspomnianych ognisk jest niezbędna w procesie przygotowawczym pacjentów kwalifikowanych do operacji okulistycznych, przeszczepów narządowych, dializoterapii, a także terapii przeciwnowotworowej. Szczególną czujność należy zachować także w przypadku pacjentów z chorobami sercowo-naczyniowymi, zwłaszcza obciążonych wysokim ryzykiem infekcyjnego zapalenia wsierdzia z powodu siniczej wrodzonej wady serca czy wszczepionej protezy zastawkowej. W pracy przedstawiono za-sadność dogłębnego postępowania diagnostyczno-terapeutycznego u wspomnianych grup pacjentów, przyt-czając metody identyfikacji ognisk oraz sposoby ich eliminacji. Podstawowym i nadrzędnym celem przedstawionych działań jest uniknięcie powikłań w postaci ciężkiej infekcji i zgonu.
The Effect of Honeybee Propolis on Escherichia coli Biofilm Formation in vitro
Authors: Puspitasari Yulianna , Grace Amazing , Khairullah Aswin Rafif , Raharjo Hartanto Mulyo , Rachmawati Kadek , Suprihatini Endang , Hisyam Mirza Atikah Madarina
Published: October 2024

Background: Colibacillosis is an infectious disease that affects livestock such as cattle, pigs, goats, sheep, horses and poultry caused by the bacterium Escherichia coli. E. coli can form biofilms when environmental conditions are unfavorable. The purpose of this research is to determine the effect of honeybee propolis on the formation of E. coli biofilm in vitro. Methods: The research began with the dilution of propolis using the microdilution technique and determination of concentration values with a modified minimum inhibitory concentration (MIC). Biofilm inhibition assays were conducted in microplates with five propolis concentration treatments: 0.39 mg/mL, 0.78 mg/mL, 1.56 mg/mL, 3.125 mg/mL and 6.25 mg/mL, along with negative and positive controls, with eight replications. Subsequently, crystal violet quantification and absorbance value readings were done using an ELISA reader with a wavelength of 595 nm. Result: The results showed that between concentrations of 3.125 mg/mL, 6.25 mg/mL and the negative control, there was no significant difference with mean values of 0.09963, 0.078857 and 0.079375, respectively. Honeybee propolis extract has the potential to act as an antibiofilm against E. coli in vitro, with the minimum concentrations capable of inhibiting biofilm formation being 3.125 mg/mL and 6.25 mg/mL.
Genetic Variability and Association Studies for Morpho-floral Traits in Backcross Introgression Lines of Rice (Oryza sativa L.)
Authors: Choudhary M. , Singh R.P. , Singh P.K. , Verma R.L. , Jayasudha S.
Published: October 2024

Background: Wild introgressions are pivotal in enriching the genetic diversity of cultivated varieties by introducing novel alleles beneficial for crop improvement. Understanding insights into genetic variability and association studies of morphological and floral traits are crucial for enhancing hybrid seed production in rice. Methods: 290 backcross introgression lines (BC4F2) from inter-specific cross of CRMS 32B (maintainer of male sterile line as low stigma exsertion recipient parent) cv. Oryza sativa with Oryza longistaminata (wild rice as high stigma exsertion donor parent) were assessed for 12 morpho-floral traits. The experiment was laid out in randomized complete block design (RCBD) at Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, during Kharif, 2019. Result: ANOVA results showed significant differences among lines for all examined traits. The phenotypic coefficient of variation (PCV) was slightly greater than genotypic coefficient of variation (GCV) for each trait. High PCV, GCV, heritability and genetic advance as percentage of mean were observed for dual stigma exsertion percentage (DSE%) and total stigma exsertion percentage (TSE%), whereas moderate to high values of these parameters were noted for single stigma exsertion percentage (SSE%), grain yield per plant (GYPP), effective tillers per plant (ETPP) and grains per panicle (GPP) traits. Most traits showed positive skewness, except traits SFP (spikelet fertility percentage), SSE% and TSE%. Most traits recorded leptokurtic kurtosis, whereas plant height (PH), GYPP and TSE% exhibited platykurtic kurtosis. TSE% displayed a highly significant positive association with SSE% and DSE%, while GYPP showed a significant positive correlation with ETPP and GPP, presenting a promising opportunity for simultaneous selection of these traits.
Nodule Associated Plant Probiotics on Seed Quality of Greengram (Vigna radiata L.) under Ambient Storage Condition
Authors: Kumar M. Vinoth , Sundaralingam K. , Geetha V. Vijaya , Vanitha C. , Vinoth K.N. , Narayanan S. Ashok
Published: October 2024

Background: India is the leading producer and importer of pulses in the world. Post-harvest storage loss ranging from 5-10% which is very high in India. This situation demands the development of storage guidelines for pulses to prevent the storage losses without deterioration. The liquid-based formulations of nodule associated plant probiotics are known for increasing the plant growth and yield related parameters in field conditions. The present study was undertaken to assess the effect of seed treatment of liquid based formulation of NAPP to maintain seed viability, vigour during storage period and also to assess the shelf life of the formulation. Methods: Population of nodule associated plant probiotics spore count was assessed in stored seeds at bimonthly intervals, SEM analysis was taken to confirm the presence of probiotics initially and effect of NAPP on seed quality during storage period was assessed. Result: The results revealed that (T3) seeds coated with microbial consortia (NAPP) of Rhizobium sp VRE1 + Candida tropicalis VYW1+ Paenibacillus taichungensis TNEB6+ AMF have recorded maximum germination (71%), germination energy (7.2) and seedling vigour index (1690). Also, coated seeds recorded highest protein content, antioxidant enzymes and lowest level of EC, free amino acids compared to control seeds after 12 months of storage under ambient condition. Microbial population was maintained at 3.2 log cfu/g of coated seeds when compared to 1.0 log cfu/g of primed seeds after one year of storage.
Morphological Changes in the Lumbar and Abdominal Muscles in Individuals with Sacralization
Authors: Çankal Fatih , Uçar İlyas , Karartı Caner , Çınaroğlu Selim
Published: October 2024

Although sacralization is one of the most common congenital anomalies of the spine, its effect on surrounding muscles is still not well known. This study was conducted to determine the size of the lumbar and abdominal muscles of the individuals with sacralization and to compare with the control group. Eighty-five participants with sacralization phenomena and fifty-six asymptomatic participants were included in this study. Sacralization was classified according to the Castellvi classification. The cross-sectional area of the multifidus lumborum, erector spinae and rectus abdominis muscles, and the section thicknesses of external abdominal oblique, internal abdominal oblique and transversus abdominis muscles were measured bilaterally on axial computed tomography images at the L1-2 and L4-5 levels. ANCOVA revealed that there is no any significant group*side interaction effect regarding muscles sizes in terms of two groups in L1-L2 and L4-L5. In addition, ANCOVA revealed a both side effect [(P=0.020; η2p=0.038)] and group*side interaction effect [(P=0.010; η2p=0.049)] regarding length of the L5 transverse process (P˃0.05). Regardless of low back pain, muscle sizes are not associated with the sacralization phenomenon.
Evaluation of Vitamin B12 deficiency Anemia in Geriatric Patients
Authors: Mete Yıldırım Aslıhan , Datlı Yakaryılmaz Funda
Published: October 2024

Objective: In our study, we aimed to evaluate vitamin B12 deficiency anemia, macrocytosis rate and vitamin B12 values in patients over 65 years of age and compare them with those under 65 years of age groups.
Method: Retrospectively, A total of 8062 patients, 1213 over the age of 65 and 6849 under the age of 65, admitted between March 2019 and March 2024 were included in the study. The patients' hemoglobin, hematocrit, Mean corpuscular volume (MCV), White blood cell (WBC), Red cell distribution width (RDW), Platelet (PLT) values and vitamin B12 levels were examined. Patients were divided into two groups as age of 65 and over ( geriatrics) and age below 65 (young-adults), and each group were divided into two groups in terms of anemia. Groups and subgropus were compared with each other.
Results: While the ratio of vitamin B12 deficiency anemia in geriatrics was 20.2%, in young-adults it was 8.3%. No difference was observed in vitamin B12 levels in terms of gender in both age groups significantly. With the roc analyses the cut-off value for vitamin B12 causing anemia in elderly patients was 327 pg/mL (AUC: 0.602, p≤0.001) with a sensitivity of 94.3% and specificity of 34.2%.
Conclusion: The fact that vitamin B12 levels that cause anemia in elderly patients are higher than in young-adult patients made us think that the usual limit values may need to be reconsiderated in geriatric population
El deporte en la comunidad de la violencia, un análisis para el caso uruguayo
Authors: Cardozo Ismael
Published: October 2024

Objetivo: En este trabajo nos proponemos problematizar la relación que se establece entre educación, deporte, seguridad y violencia para el caso de la política pública en Uruguay. Método: Para tal cometido analizamos un programa del Ministerio del Interior de Uruguay, denominado Pelota al Medio a la esperanza. Este utiliza al deporte como herramienta con el fin de superar la violencia y mejorar la convivencia ciudadana. En esta ocasión examinamos ciertos documentos pertenecientes al programa así como entrevistas realizadas a informantes claves que participan en la planificación, coordinación y puesta en práctica de las actividades de Pelota al medio a la esperanza. También estudiamos dos documentos importantes de la década de los 90 ya que constituyen antecedentes relevantes en la relación inicialmente mencionada. Estos son el Proyecto de Ley de Seguridad Ciudadana y la Ley del mismo nombre. Resultados: Este primer análisis desde una perspectiva de la gubernamentalidad nos permite adelantar que esta práctica llevada adelante por el Estado, se inscribe en un ejercicio que no actúa en lo social como territorio de gobierno, sino que resalta y actúa en la comunidad identificándola a partir de asignarle, ciertas características. Consideraciones Finales: A partir de lo abordado en el trabajo, consideramos que es posible elaborar un diagnóstico acerca de la relación educación, deporte, seguridad y violencia que permita maximizar las potencialidades de los colectivos, poniendo el acento en la cuestión social y lo universal en la comprensión de los emergentes sociales.
Longitudinal Changes in Brain Connectivity Correlate with Neuropsychological Testing in Brain Tumor Resection Patients
Authors: Ellis David G , Warren David , Garlinghouse Matthew , Aizenberg Michele R
Published: October 2024

Background: Patients undergoing brain tumor resection experience neurological and cognitive (i.e., neurocognitive) changes reflected in altered performance on neuropsychological tests. These changes can be difficult to explain or predict. Brain connectivity, measured with neuroimaging, offers one potential model for examining these changes. In this study, we evaluated whether longitudinal changes in brain connectivity correlated with changes in neurocognitive abilities in patients before and after brain tumor resection.
Methods: Patients underwent functional and diffusion MR scanning and neuropsychological evaluation before tumor resection followed by repeat scanning and evaluation two weeks post-resection. Using this functional and diffusion imaging data, we measured changes in the topology of the functional and structural networks. From the neuropsychological testing scores, we derived a composite score that described a patient’s overall level of neurocognitive functioning. We then used a multiple linear regression model to test whether structural and functional connectivity measures were correlated with changes in composite scores.
Results: Multiple linear regression on 21 subjects showed that connectivity changes were highly correlated with changes in neuropsychological evaluation scores (R2 adjusted = 0.79, p<0.001). Changes in functional local efficiency (p<0.001) and global efficiency (p<0.05) were inversely correlated with changes in composite score, while changes in modularity (p<0.01) as well as the patient’s age (p<0.05) were directly correlated with changes in composite score.
Conclusion: Short interval changes in brain connectivity markers were strongly correlated with changes in the composite neuropsychological test scores in brain tumor resection patients. Our findings support the need for further exploration of brain connectivity as a biomarker relevant to brain tumor patients.
Three-Dimensional Printing/Bioprinting and Cellular Therapies for Regenerative Medicine: Current Advances
Authors: Sousa Ana Catarina , Alvites Rui , Lopes Bruna , Sousa Patrícia , Moreira Alícia , Coelho André , Santos José Domingos , Atayde Luís , Alves Nuno , Maurício Ana Colette
Published: October 2024

The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field of regen-erative medicine. This paper aims to provide a comprehensive overview of 3D print-ing/bioprinting technology and cell therapies, highlighting their results in diverse medical applications, while also discussing the capabilities and limitations of their com-bined use. The synergistic combination of 3D printing and cellular therapies has been recognised as a promising and innovative approach, and it is expected that these tech-nologies will progressively assume a crucial role in the treatment of various diseases and conditions in the foreseeable future. This review concludes with a forward-looking perspective on the future impact of these technologies, highlighting their potential to revolutionize regenerative medicine through enhanced tissue repair and organ re-placement strategies.
New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-Inflammatory, DNA Gyrase B Inhibition and In Silico Studies
Authors: Abd El-Karim Somaia S. , Anwar Manal M. , Syam Yasmin M. , Awad Hassan M. , El-Dein Asmaa Negm , El-Ashrey Mohamed K. , Alkahtani Hamad M. , Abdelwahed Sameh H
Published: October 2024

The alarming rise of antibiotic resistance has made it imperative to find novel antimicrobial medications. This study reports the design and synthesis of new molecules based on benzofu-ran-pyrazole scaffolds hybridized with various N/O heterocycles using the molecular hybridiza-tion process. The newly synthesized candidates were confirmed using micro-analytical and spectral analyses, and their antimicrobial characteristics were assessed against different bacterial and fungal isolates in comparison with novobiocin and clotrimazole as antibacterial and anti-fungal standards, respectively. In addition, the new compounds were further evaluated as in vitro antioxidants and anti-inflammatory congeners. The most promising broad spectrum antimicrobial compounds 9, 10 with values ranging from 2.50-20.60 μg/mL were further examined as E. coli DNA gyrase B enzyme suppressors using novobiocin as a reference drug. In silico computational and ADMET studies were carried out for the most active compounds.
The Effect of a Care Bundle on the Rate of Blood Culture Contamination in a General ICU
Authors: Veini Fani , Samarkos Michael , Voutsinas Pantazis-Michael , Kotanidou Anastasia
Published: October 2024

Background/Objectives: A blood culture (BC) care bundle is aimed at decreasing BC contamination rate. This study examined prospectively the effect of a care bundle on BC contamination rates in a high workload ICU. Methods: We performed a before-after study in a general ICU, from January 2018 to May 2019. Blood culture sets were classified as positive, contaminated, indeterminate and negative. We used bivariate and interrupted time series analysis to assess the effect of the intervention and factors associated with contamination rates. Results: During the study, a total of 4236 BC vials were collected. BC Contamination rate decreased significantly after the intervention from 6.2% to 1.3%. Incidence rate of contaminated BC sets was significantly lower in the POST phase: 0.461 vs 0.154 BC sets per 100 ICU bed-days. Overall compliance with the BC care bundle increased from 3.4% to 96.9%. Conclusions: The care bundle was effective in reducing BC contamination and improving several quality indicators in our setting. The indeterminate BC rate is an important problem, and we suggest that it should be included in BC quality indicators. : The BC care bundle implementation was effective in reducing BC contamination rate, although its long-term effect was not assessed.
Pharmacological Study of Amaranthus spinosus L. Root Extract on High-Fat Diet and Low-Dose Streptozocin-Induced Type 2 Diabetes Complications in Rats
Authors: Atchou Kokou , Lawson-Evi Povi , Eklu-Gadegbeku Kwashie
Published: October 2024

Diabetes complications appear with the severity of hyperglycemia and the age of the disease. In type 2 diabetes mellitus (T2DM), herbal medicines are also effective in reducing hyperglycemia and can be used for this purpose to manage complications. This study aimed to prove the effectiveness of Amaranthus spinosus root extract on type 2 diabetes (T2D) and its microvascular complications. A high-fat diet and low-dose streptozocin were used for 20 days to induce T2D syndrome and complications in rats. The validated animal models were treated orally with the dried hydroethanolic extract of A. spinosus for three weeks; then the hematological, biochemical, and histological markers were evaluated. The results showed that the extract at a dose of 500 mg/kg bw was effective against diabetes and its complications. This effectiveness was linked to a significant reduction (p < 0.0001) in basal blood glucose, tissue oxidative stress, serum cardiovascular and hepato-renal markers, and an improvement in insulin secretion and utilization. The protective activity of the extract against macular edema and renal fibrosis was confirmed by histopathological examinations. These findings prove that A. spinosus root extract contains bioactive compounds that may be useful in preventing or reversing diabetic retinopathy and renal fibrosis.
Review of Epiretinal Protheses Technologies
Authors: Liang Zilong
Published: October 2024

Electronic devices called epiretinal prosthesis are used to restore vision in patients with age-related macular degeneration (AMD) and retinitis pigmentosa (RP), two degenerative retinal illnesses. It functions by stimulating the retina's surviving cells, which then excite the brain to receive visual information from the retina. Epiretinal prosthesis have the flexibility of electrode placement, which enables them to target particular regions of the retina. Furthermore, it enables a high level of spatial resolution, enhancing visual quality. For the purpose of activating retinal cells, it transforms visual input into electrical signals. In general, epiretinal prosthesis are a potential method for helping people with degenerative retinal illnesses regain their vision. Ongoing research aims to increase the effectiveness and safety of these devices.
Tympanic Pre-Operative Electrically Evoked Auditory Late Response (TympEALR) as an Alternative to Trans-Tympanic Tests Using Anesthesia in Cochlear Implant Candidacy
Authors: Polterauer Daniel , Neuling Maike , Simon Florian
Published: October 2024

Background/Objectives: Before a cochlear implant is considered, patients undergo various audiological tests to assess their suitability. One key test measures the auditory brainstem response (ABR) to acoustic stimuli. However, in some cases, even with maximum sound stimulation, no response is detected. Methods: The promontory test involves electrical stimulation near the auditory nerve, allowing patients to associate the sensation. Ideally, the electrode is placed in the middle ear after opening the eardrum. This method, along with LA-TT-EABR and LA-TT-EALR, helps assess the auditory nerve's existence and excitability. The TympEALR test, utilizing a tympanic PromCERA, provides an alternative measurement. Previous research has shown the possibility of deriving brainstem and cortical potentials through trans-tympanic electrical stimulation, allowing for objective assessment of the auditory nerve's integrity and potentially objectifying patient sensations. Results: Sixteen patients have been tested using TympEALR. In seven of these, we found a positive response. The morphology was similar to other EALRs, e.g., using cochlear implants or trans-tympanic stimulation electrodes. We observed a higher influence of electrical artifacts than in other EALRs. Conclusions: TympEALR showed positive results in nearly half of the study participants, potentially avoiding invasive procedures. TympEALR can be a valuable alternative to trans-tympanic methods. More research is needed to determine if a negative result suggests against cochlear implantation.