bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S2 from ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-guided Analysis
Authors: Arrieta Víctor A. , Duerinck Johnny , Burdett Kirsten B. , Habashy Karl J. , Geens Wietse , Gould Andrew , Schwarze Julia K. , Dmello Crismita , Kim Kwang-Soo , Saganty Ruth , Chen Li , Moscona Alberto , McCord Matthew , Lee-Chang Catalina , Horbinski Craig M. , Zhang Hui , Stupp Roger , Neyns Bart , Sonabend Adam M.
Published: January 2024

Supplementary Figure 2. Survival outcomes of high-grade gliomas in evaluable patients
Supplementary Figure S1 from ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-guided Analysis
Authors: Arrieta Víctor A. , Duerinck Johnny , Burdett Kirsten B. , Habashy Karl J. , Geens Wietse , Gould Andrew , Schwarze Julia K. , Dmello Crismita , Kim Kwang-Soo , Saganty Ruth , Chen Li , Moscona Alberto , McCord Matthew , Lee-Chang Catalina , Horbinski Craig M. , Zhang Hui , Stupp Roger , Neyns Bart , Sonabend Adam M.
Published: January 2024

Supplementary Figure 1. Workflow employed for software-assisted quantification of immunohistochemistry through the marking of p-ERK+ cells.
Supplementary Figure S1 from SAR-096: Phase II Clinical Trial of Ribociclib in Combination with Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
Authors: Movva Sujana , Matloob Sahar , Handorf Elizabeth A. , Choy Edwin , Merriam Priscilla , Flieder Douglas B. , Cai Kathy Q. , Zhou Yan , Tetzlaff Eric D. , Pagan Cheyenne , Barker Emma , Veggeberg Rosanna , Zumpano Delia , Rink Lori , von Mehren Margaret , George Suzanne
Published: January 2024

Supplementary Figure S1: IHC. Representative examples of staining of Rb (left) and PTEN (right) expression in LMS patients that demonstrated response (top) and nonresponse (bottom).
Supplementary Data File 1 from CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis
Authors: Nayyar Naema , de Sauvage Magali A. , Chuprin Jane , Sullivan Emily M. , Singh Mohini , Torrini Consuelo , Zhang Britney S. , Bandyopadhyay Sushobhana , Daniels Keith A. , Alvarez-Breckenridge Christopher , Dahal Ashish , Brehm Michael A. , Brastianos Priscilla K.
Published: January 2024

Figures S1-13, Tables S1-2
Supplementary Table S4 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Table S4. The top 20 cfmiRs that are commonly DE in chordoma vs normal healthy donor plasma samples.
Supplementary Figure S4 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Supplementary Figure S4. Significant cfmiRs found in plasma and tissues.
A. Venn diagram showing the cfmiRs differentially expressed detected in plasma of chordoma patients that were also detected in tissue samples from chordoma patients (normalized counts >30). B. Venn diagram showing the common cfmiRs found in plasma samples considering the top 100 cfmiRs most detected, most significant changing, and most upregulated that were identified for chordoma vs normal healthy donors (NHDs). 38 cfmiRs were commonly identified as the most significantly changing, upregulated, and detected in chordoma patients.
Supplementary Figure S3 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Supplementary Figure S3. CT images of patient P08 treated with innumerable metastatic sacral chordoma to lungs and skin. Chest CT before treatment (A-B) and 6 weeks after initiation of high-dose pemetrexed (D-F) showing shrinkage of some lesions.
Supplementary Figure S2 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Supplementary Figure S2. MRI and CT images of patient P04 with metastatic spinal chordoma in C-spine and lung. C-spine MRI before treatment (A-B) shows C-spine disease (arrows) and 12 months after initiation of high-dose pemetrexed (D-E) shows shrinkage of enhancing tumor on sagittal post contrast T1 sequences (A, D), sagittal T2 (B, E). Chest CT before treatment (C) showed multiple small metastases at baseline axial post contrast sequences that resolved after treatment (F).
Table S5 from Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma
Authors: Pan Minggui , Zhou Maggie Yuxi , Jiang Chen , Zhang Zheyang , Bui Nam Q. , Bien Jeffrey , Siy Amanda , Achacoso Ninah , Solorzano Aleyda V. , Tse Pamela , Chung Elaine , Thomas Sachdev , Habel Laurel A. , Ganjoo Kristen N.
Published: January 2024

Demographics of patients with wt and mut ATRX.
Supplementary Figure S1 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Supplementary Figure S1. MR images of patient P05 with locally advanced clival chordoma. Brain MRI before treatment (A-C) shows left cavernous since disease (arrows), 6 months after initiation of high-dose pemetrexed (D-F), and 12 months after treatment initiation (G-J) showing shrinkage of enhancing tumor on axial post contrast T1 sequences (A, D, G), axial FLAIR (B, E, H) and axial T2 (C, F, I).
Table S4 from Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma
Authors: Pan Minggui , Zhou Maggie Yuxi , Jiang Chen , Zhang Zheyang , Bui Nam Q. , Bien Jeffrey , Siy Amanda , Achacoso Ninah , Solorzano Aleyda V. , Tse Pamela , Chung Elaine , Thomas Sachdev , Habel Laurel A. , Ganjoo Kristen N.
Published: January 2024

Demographics of patients with wt and mut PTEN.
Supplementary Table S2 from PDGFRβ Signaling Cooperates with β-Catenin to Modulate c-Abl and Biologic Behavior of Desmoid-Type Fibromatosis
Authors: Hu Jia , Hameed Meera R. , Agaram Narasimhan P. , Whiting Karissa A. , Qin Li-Xuan , Villano Anthony M. , O'Connor Rachael B. , Rozenberg Julian M. , Cohen Sonia , Prendergast Katherine , Kryeziu Sara , White Richard L. , Posner Mitchell C. , Socci Nicholas D. , Gounder Mrinal M. , Singer Samuel , Crago Aimee M.
Published: January 2024

Genes included in HIF1- and angiogenesis-related pathways and used for supervised clustering of desmoid tumors. Pathways in which each gene are included are annotated in the table.
Supplementary Table S1 from Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study
Authors: Belge Gazanfer , Dumlupinar Cansu , Nestler Tim , Klemke Markus , Törzsök Peter , Trenti Emanuela , Pichler Renate , Loidl Wolfgang , Che Yue , Hiester Andreas , Matthies Cord , Pichler Martin , Paffenholz Pia , Kluth Luis , Wenzel Mike , Sommer Jörg , Heinzelbecker Julia , Schriefer Philipp , Winter Alexander , Zengerling Friedemann , Kramer Mario Wolfgang , Lengert Marie , Frey Jana , Heidenreich Axel , Wülfing Christian , Radtke Arlo , Dieckmann Klaus-Peter
Published: January 2024

Supplementary Table S1. Follow-up schedule of clinical stage I seminoma patients used in the study (modified from Oldenburg et al., Ann. Oncol. 2022, and Kliesch et al. Urol. int. 2021)
Supplementary Figure S2 from Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study
Authors: Belge Gazanfer , Dumlupinar Cansu , Nestler Tim , Klemke Markus , Törzsök Peter , Trenti Emanuela , Pichler Renate , Loidl Wolfgang , Che Yue , Hiester Andreas , Matthies Cord , Pichler Martin , Paffenholz Pia , Kluth Luis , Wenzel Mike , Sommer Jörg , Heinzelbecker Julia , Schriefer Philipp , Winter Alexander , Zengerling Friedemann , Kramer Mario Wolfgang , Lengert Marie , Frey Jana , Heidenreich Axel , Wülfing Christian , Radtke Arlo , Dieckmann Klaus-Peter
Published: January 2024

Supplementary Figure S2. Frequencies of marker elevations in relapsing and non-relapsing patients
Supplementary Figure S1 from Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study
Authors: Belge Gazanfer , Dumlupinar Cansu , Nestler Tim , Klemke Markus , Törzsök Peter , Trenti Emanuela , Pichler Renate , Loidl Wolfgang , Che Yue , Hiester Andreas , Matthies Cord , Pichler Martin , Paffenholz Pia , Kluth Luis , Wenzel Mike , Sommer Jörg , Heinzelbecker Julia , Schriefer Philipp , Winter Alexander , Zengerling Friedemann , Kramer Mario Wolfgang , Lengert Marie , Frey Jana , Heidenreich Axel , Wülfing Christian , Radtke Arlo , Dieckmann Klaus-Peter
Published: January 2024

Supplementary Figure S1. Performance characteristics of M371 test for relapse detection, separate analysis of seminoma and nonseminoma
Table S4 from Phase I/IIa Trial in Advanced Pancreatic Ductal Adenocarcinoma Treated with Cytotoxic Drug-Packaged, EGFR-Targeted Nanocells and Glycolipid-Packaged Nanocells
Authors: Ganju Vinod , Marx Gavin , Pattison Scott , Amaro-Mugridge Nancy B. , Zhao Jing-Ting , Williams Bryan R.G. , MacDiarmid Jennifer A. , Brahmbhatt Himanshu
Published: January 2024

Table S4: Prior Cancer Treatment by Individual Patient
Supplementary Table S7 from Induction Toripalimab and Chemotherapy for Organ Preservation in Locally Advanced Laryngeal and Hypopharyngeal Cancer: A Single-Arm Phase II Clinical Trial
Authors: Ou Xiaomin , Zhai Ruiping , Wei Wenjun , Chen Jiaying , Ou Dan , Liao Tian , Xu Tingting , Zhu Yongxue , Wang Yulong , Huang Shenglin , Shi Rongliang , Wu Bin , Chen Tongzhen , Li Yuan , Yang Zhongyi , Zhou Changming , Liu Yuan , Jiang Ziting , Zeng Min , Liu Xin , Ji Dongmei , Ying Hongmei , Zhang Zhen , Hu Chaosu , Lu Xueguan , Ji Qinghai , He Xiayun , Wang Yu
Published: January 2024

Subsequent treatment upon disease progression
Table S1 from Phase I/IIa Trial in Advanced Pancreatic Ductal Adenocarcinoma Treated with Cytotoxic Drug-Packaged, EGFR-Targeted Nanocells and Glycolipid-Packaged Nanocells
Authors: Ganju Vinod , Marx Gavin , Pattison Scott , Amaro-Mugridge Nancy B. , Zhao Jing-Ting , Williams Bryan R.G. , MacDiarmid Jennifer A. , Brahmbhatt Himanshu
Published: January 2024

Table S1: Dosing Regimens (Extended)
Supplementary Table S5 from Induction Toripalimab and Chemotherapy for Organ Preservation in Locally Advanced Laryngeal and Hypopharyngeal Cancer: A Single-Arm Phase II Clinical Trial
Authors: Ou Xiaomin , Zhai Ruiping , Wei Wenjun , Chen Jiaying , Ou Dan , Liao Tian , Xu Tingting , Zhu Yongxue , Wang Yulong , Huang Shenglin , Shi Rongliang , Wu Bin , Chen Tongzhen , Li Yuan , Yang Zhongyi , Zhou Changming , Liu Yuan , Jiang Ziting , Zeng Min , Liu Xin , Ji Dongmei , Ying Hongmei , Zhang Zhen , Hu Chaosu , Lu Xueguan , Ji Qinghai , He Xiayun , Wang Yu
Published: January 2024

Larynx preservation rate at three months post-radiotherapy according to T stage and pretreatment laryngeal function and baseline invasion (N=27)
Supplementary Table S3 from Induction Toripalimab and Chemotherapy for Organ Preservation in Locally Advanced Laryngeal and Hypopharyngeal Cancer: A Single-Arm Phase II Clinical Trial
Authors: Ou Xiaomin , Zhai Ruiping , Wei Wenjun , Chen Jiaying , Ou Dan , Liao Tian , Xu Tingting , Zhu Yongxue , Wang Yulong , Huang Shenglin , Shi Rongliang , Wu Bin , Chen Tongzhen , Li Yuan , Yang Zhongyi , Zhou Changming , Liu Yuan , Jiang Ziting , Zeng Min , Liu Xin , Ji Dongmei , Ying Hongmei , Zhang Zhen , Hu Chaosu , Lu Xueguan , Ji Qinghai , He Xiayun , Wang Yu
Published: January 2024

Overall response rate of induction chemoimmunotherapy (N=27)
Supplementary Methods S1 from Induction Toripalimab and Chemotherapy for Organ Preservation in Locally Advanced Laryngeal and Hypopharyngeal Cancer: A Single-Arm Phase II Clinical Trial
Authors: Ou Xiaomin , Zhai Ruiping , Wei Wenjun , Chen Jiaying , Ou Dan , Liao Tian , Xu Tingting , Zhu Yongxue , Wang Yulong , Huang Shenglin , Shi Rongliang , Wu Bin , Chen Tongzhen , Li Yuan , Yang Zhongyi , Zhou Changming , Liu Yuan , Jiang Ziting , Zeng Min , Liu Xin , Ji Dongmei , Ying Hongmei , Zhang Zhen , Hu Chaosu , Lu Xueguan , Ji Qinghai , He Xiayun , Wang Yu
Published: January 2024

Supplementary methods
Supplementary Table S5 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Table S5. Summary of sequence alterations identified in cell-fee DNA.
Supplementary Table S4 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Table S4. Summary of whole exome sequencing characteristics for tumor and matched normal samples analyzed.
Supplementary Table S2 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Table S2. Summary of genes analyzed by targeted error-correction sequencing (TEC-Seq).
Supplementary Figure S3 from Induction Toripalimab and Chemotherapy for Organ Preservation in Locally Advanced Laryngeal and Hypopharyngeal Cancer: A Single-Arm Phase II Clinical Trial
Authors: Ou Xiaomin , Zhai Ruiping , Wei Wenjun , Chen Jiaying , Ou Dan , Liao Tian , Xu Tingting , Zhu Yongxue , Wang Yulong , Huang Shenglin , Shi Rongliang , Wu Bin , Chen Tongzhen , Li Yuan , Yang Zhongyi , Zhou Changming , Liu Yuan , Jiang Ziting , Zeng Min , Liu Xin , Ji Dongmei , Ying Hongmei , Zhang Zhen , Hu Chaosu , Lu Xueguan , Ji Qinghai , He Xiayun , Wang Yu
Published: January 2024

Changes of quality of life at different timepoints
Supplementary Table S1 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Table S1. Clinical characteristics of the patients included in ctDNA analyses.
Supplementary Figure S3 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Fig.S3 Associations between ctDNA molecular responses and progression-free (PFS) and overall (OS)
survival. Molecular responses were significantly associated with both PFS (A) and OS (B) in all 26 patients with detectable cfTL (log-rank p value 0.001 and 0.04, respectively). Patients with a molecular response (mR) are shown in blue,
patients with a molecular response followed by either recrudescence or emergence (mR f/b REC/EM) are shown in light
blue and patients with molecular progression (mPD) are shown in yellow. (C, D) Analyses shown in (A) and (B) were
repeated with the subset of patients (n=4) who were classified as having undetectable cfTL (grey). (E, F) Associations
between the presence (light blue) or absence (coral) of a molecular response, defined by cfTL clearance across any
sampled timepoint, and survival outcomes, including cases with undetectable cfTL (grey). (G, F) Associations between
molecular responses and survival outcomes in patients with a best overall radiographic response assessment of stable
disease.
Supplementary Figure S1 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Fig.S1 Overview of branched logic architecture used for the classification of variant cellular origin in plasma. Cell-free DNA (cfDNA) variants in plasma were assigned an origin classification of tumor-, germline- or clonal haematopoiesis
(CH)-derived, using all available sequencing data. Patients with matched tumor tissue next-generation sequence (NGS) data available (n=24) from either whole exome sequencing or clinical tumor mutation profiling, were evaluated using our tumor-informed
approach (Methods) for the identification of circulating tumor DNA (ctDNA) variants. As single tissue biopsies can be limited by sampling heterogeneity, patients with matched tumor NGS but no detectable tissue-specific variants in plasma (n=3) were further
evaluated using our WBC-informed approach for identification of ctDNA variants missing by tissue sequencing. Patients with no detectable tumor-derived variants in plasma according to both approaches were subsequently classified as undetectable. Six
patients without matched tumor tissue NGS available were evaluated using our WBC-informed approach for assignment of variant cellular origin (Methods). VUO, variant of unknown origin.
Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Authors: Petronek Michael S. , Monga Varun , Bodeker Kellie L. , Kwofie Michael , Lee Chu-Yu , Mapuskar Kranti A. , Stolwijk Jeffrey M. , Zaher Amira , Wagner Brett A. , Smith Mark C. , Vollstedt Sandy , Brown Heather , Chandler Meghan L. , Lorack Amanda C. , Wulfekuhle Jared S. , Sarkaria Jann N. , Flynn Ryan T. , Greenlee Jeremy D.W. , Howard Matthew A. , Smith Brian J. , Jones Karra A. , Buettner Garry R. , Cullen Joseph J. , St-Aubin Joel , Buatti John M. , Magnotta Vincent A. , Spitz Douglas R. , Allen Bryan G.
Published: January 2024

Study Representativeness Table
Data from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

AbstractPurpose:
Although immunotherapy is the mainstay of therapy for advanced non–small cell lung cancer (NSCLC), robust biomarkers of clinical response are lacking. The heterogeneity of clinical responses together with the limited value of radiographic response assessments to timely and accurately predict therapeutic effect—especially in the setting of stable disease—calls for the development of molecularly informed real-time minimally invasive approaches. In addition to capturing tumor regression, liquid biopsies may be informative in capturing immune-related adverse events (irAE).
Experimental Design:
We investigated longitudinal changes in circulating tumor DNA (ctDNA) in patients with metastatic NSCLC who received immunotherapy-based regimens. Using ctDNA targeted error-correction sequencing together with matched sequencing of white blood cells and tumor tissue, we tracked serial changes in cell-free tumor load (cfTL) and determined molecular response. Peripheral T-cell repertoire dynamics were serially assessed and evaluated together with plasma protein expression profiles.
Results:
Molecular response, defined as complete clearance of cfTL, was significantly associated with progression-free (log-rank P = 0.0003) and overall survival (log-rank P = 0.01) and was particularly informative in capturing differential survival outcomes among patients with radiographically stable disease. For patients who developed irAEs, on-treatment peripheral blood T-cell repertoire reshaping, assessed by significant T-cell receptor (TCR) clonotypic expansions and regressions, was identified on average 5 months prior to clinical diagnosis of an irAE.
Conclusions:
Molecular responses assist with the interpretation of heterogeneous clinical responses, especially for patients with stable disease. Our complementary assessment of the peripheral tumor and immune compartments provides an approach for monitoring of clinical benefits and irAEs during immunotherapy.
Data from A Phase I Study of the CDK4/6 Inhibitor Palbociclib in Combination with Cetuximab and Radiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma
Authors: Ngamphaiboon Nuttapong , Pattaranutaporn Poompis , Lukerak Somthawin , Siripoon Teerada , Jinawath Artit , Arsa Lalida , Shantavasinkul Prapimporn Ch. , Taonam Naphat , Trachu Narumol , Jinawath Natini , Kositwattanarerk Arpakorn , Sananmuang Thiparom , Jiarpinitnun Chuleeporn
Published: January 2024

AbstractPurpose:
Palbociclib, a cyclin D kinase 4 (CDK4)/6 inhibitor, has shown radiosensitizing effects in preclinical studies. There is a strong rationale for adding palbociclib to cetuximab and radiotherapy in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), especially in p16-negative HNSCC.
Patients and Methods:
We conducted a phase I dose-escalation study (NCT03024489) using a classical 3+3 design to determine safety, tolerability, and MTD of palbociclib, cetuximab, and intensity-modulated radiotherapy (IMRT) combination. At the recommended phase II dose (RP2D), additional p16-negative patients were enrolled.
Results:
Twenty-seven patients with LA-HNSCC (13 in dose escalation, 14 in expansion) with oropharyngeal (41%) and hypopharyngeal (30%) cancers were enrolled. The MTD was not reached, and the RP2D of palbociclib was established at the full standard palbociclib dose of 125 mg/day for 21 days per cycle, administered for two cycles during IMRT. The most common grade 3–4 toxicities were mucositis (59%), radiation dermatitis (22%), and neutropenia (22%), with a febrile neutropenia rate of 7%. Common genomic alterations included mutations in TP53 (57%), GNAQ (35%), and PIK3CA (17%), and copy-number gains in CCND1 (22%), CCND2 (9%), and EGFR (9%). Overall, p16 expression was positive in 15% of patients. No correlation was observed between p16 status, genomic alterations, and preliminary efficacy. The objective response rate was 84%. The rates for 2-year locoregional control, event-free survival, and overall survival were 73%, 48%, and 71%, respectively.
Conclusions:
The palbociclib, cetuximab, and IMRT combination was well tolerated. The RP2D was established, while no MTD was determined. The regimen demonstrated promising preliminary efficacy, suggesting further investigation is warranted in patients with cisplatin-ineligible p16/human papilloma virus–unrelated LA-HNSCC.
Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: January 2024

Purpose:

DNA methylation causes silencing of tumor-suppressor and differentiation-associated genes, being linked to chemoresistance. Previous studies demonstrated that hypomethylating agents (HMA) resensitize ovarian cancer to chemotherapy. NTX-301 is a highly potent and orally bioavailable HMA, in early clinical development.

Experimental Design:

The antitumor effects of NTX-301 were studied in ovarian cancer models by using cell viability, stemness and ferroptosis assays, RNA sequencing, lipidomic analyses, and stimulated Raman spectroscopy.

Results:

Ovarian cancer cells (SKOV3, IC50 = 5.08 nmol/L; OVCAR5 IC50 = 3.66 nmol/L) were highly sensitive to NTX-301 compared with fallopian tube epithelial cells. NTX-301 downregulated expression of DNA methyltransferases 1–3 and induced transcriptomic reprogramming with 15,000 differentially expressed genes (DEG, P < 0.05). Among them, Gene Ontology enrichment analysis identified regulation of fatty acid biosynthesis and molecular functions related to aldehyde dehydrogenase (ALDH) and oxidoreductase, known features of cancer stem cells. Low-dose NTX-301 reduced the ALDH(+) cell population and expression of stemness-associated transcription factors. Stearoyl-coenzyme A desaturase 1 (SCD), which regulates production of unsaturated fatty acids (UFA), was among the top DEG downregulated by NTX-301. NTX-301 treatment decreased levels of UFA and increased oxidized lipids, and this was blunted by deferoxamine, indicating cell death via ferroptosis. NTX-301–induced ferroptosis was rescued by oleic acid. In vivo, monotherapy with NTX-301 significantly inhibited ovarian cancer and patient-derived xenograft growth (P < 0.05). Decreased SCD levels and increased oxidized lipids were detected in NTX-301–treated xenografts.

Conclusions:

NTX-301 is active in ovarian cancer models. Our findings point to a new mechanism by which epigenetic blockade disrupts lipid homeostasis and promotes cancer cell death.
Translating Science into Survival: Report on the Seventh International Cancer Immunotherapy Conference
Authors: Beck Jan D. , Kenski Juliana , Perrone Milena , Pocaterra Arianna , Honey Karen
Published: January 2024

From September 20 to 23, 2023, the Seventh International Cancer Immunotherapy Conference was hosted jointly by the Cancer Research Institute, the European Network for Cancer Immunotherapy (ENCI), and the American Association for Cancer Research (AACR) in Milan, Italy. The four-day event covered the latest advances in cancer immunology and immunotherapy.
Synergistic Drug Combinations Promote the Development of Resistance in Acute Myeloid Leukemia
Authors: Mason-Osann Emily , Pomeroy Amy E. , Palmer Adam C. , Mettetal Jerome T.
Published: January 2024

Combination therapy is an important part of cancer treatment and is often employed to overcome or prevent drug resistance. Preclinical screening strategies often prioritize synergistic drug combinations; however, studies of antibiotic combinations show that synergistic drug interactions can accelerate the emergence of resistance because resistance to one drug depletes the effect of both. In this study, we aimed to determine whether synergy drives the development of resistance in cancer cell lines using live-cell imaging. Consistent with prior models of tumor evolution, we found that when controlling for activity, drug synergy is associated with increased probability of developing drug resistance. We demonstrate that these observations are an expected consequence of synergy: the fitness benefit of resisting a drug in a combination is greater in synergistic combinations than in nonsynergistic combinations. These data have important implications for preclinical strategies aiming to develop novel combinations of cancer therapies with robust and durable efficacy.

Significance:

Preclinical strategies to identify combinations for cancer treatment often focus on identifying synergistic combinations. This study shows that in AML cells combinations that rely on synergy can increase the likelihood of developing resistance, suggesting that combination screening strategies may benefit from a more holistic approach rather than focusing on drug synergy.

See related commentary by Bhola and Letai, p. 81.

This article is featured in Selected Articles from This Issue, p. 80
TABLE 1 from WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers
Authors: Sottnik Joseph L. , Shackleford Madeleine T. , Robinson Sydney K. , Villagomez Fabian R. , Bahnassy Shaymaa , Oesterreich Steffi , Hu Junxiao , Madak-Erdogan Zeynep , Riggins Rebecca B. , Corr Bradley R. , Cook Linda S. , Treviño Lindsey S. , Bitler Benjamin G. , Sikora Matthew J.
Published: January 2024

Gynecologic tumor cohort for RPPA analyses total n = 103
Supplementary File 1 from WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers
Authors: Sottnik Joseph L. , Shackleford Madeleine T. , Robinson Sydney K. , Villagomez Fabian R. , Bahnassy Shaymaa , Oesterreich Steffi , Hu Junxiao , Madak-Erdogan Zeynep , Riggins Rebecca B. , Corr Bradley R. , Cook Linda S. , Treviño Lindsey S. , Bitler Benjamin G. , Sikora Matthew J.
Published: January 2024

BioID raw data
FIGURE 7 from WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers
Authors: Sottnik Joseph L. , Shackleford Madeleine T. , Robinson Sydney K. , Villagomez Fabian R. , Bahnassy Shaymaa , Oesterreich Steffi , Hu Junxiao , Madak-Erdogan Zeynep , Riggins Rebecca B. , Corr Bradley R. , Cook Linda S. , Treviño Lindsey S. , Bitler Benjamin G. , Sikora Matthew J.
Published: January 2024

WNT4 variant genotype is associated with active WNT4 signaling and metabolic remodeling in ovarian cancer cells. A, Left, Proliferation assessed by dsDNA quantification 6 days post-transfection with siRNA (siNT = non-targeting control pool). Bars represent mean of 6 biological replicates ± SD; *, P < 0.05, siWNT4 versus siNT, t test with Welch correction. WT versus Var model comparison by t test of mean fold changes for siWNT4 versus siNT. Right, WNT4 mRNA by qPCR in parallel samples, 72 hours after siRNA. Mean of biological triplicate, fold change versus siNT. B, Lysates harvested 72 hours posttransfection. MCL1 levels assessed by densitometry and normalized to total S6 loading control (6). Fold change in normalized MCL1 levels in Variant versus WT genotype cell lines compared by Student t test. C, Metabolites dysregulated 72 hours after WNT4 knockdown (n = 44), as for MM134. D, Fold changes in lipid metabolites. Dashed line on y-axis: FDR = 0.2. E, Pathway enrichment (Metaboanalyst) for metabolites shown in C; K = KEGG, S = SMPDB.
Health-Related Complications during Follow-Up and Their Impact on Blood Cancer Survivors: Results from the “Aftercare in Blood Cancer Survivors” (ABC) Study
Authors: Baum Julia , Lax Hildegard , Lehmann Nils , Merkel-Jens Anja , Beelen Dietrich W. , Jöckel Karl-Heinz , Dührsen Ulrich
Published: January 2024

Introduction: Blood cancer survivors are at increased risk for medical complications. Methods: Our questionnaire-based study involved 1,551 blood cancer survivors with a ≥3-year interval since the last intense treatment. Its goal was to quantify health-related complications during follow-up and assess their impact on the patients’ lives. Results: A total of 20.4% of the responding survivors reported a disease relapse, most often in indolent lymphomas. Second primary malignancies occurred in 14.1%, primarily in lymphoma and allogeneic transplantation survivors. The most frequent malignancy was basal cell carcinoma of the skin, but myeloid malignancies, melanoma, bladder, head-and-neck, and thyroid cancer also appeared disproportionately frequent. An increased infection rate was reported by 43.7%, most often after allogeneic transplantation. New cardiovascular diseases were reported by 30.2%, with a high rate of thromboembolic events in multiple myeloma (MM) and myeloproliferative diseases. Polyneuropathies were reported by 39.1%, most often by survivors with a history of MM or aggressive lymphoma. Disease relapse was perceived as the highest burden, followed by second primary malignancy, increased infection frequency, and polyneuropathy. In each area investigated, the range of perceived severities was wide. Conclusions: Health-related complications are frequent during blood cancer follow-up, with significant repercussions on the patients’ lives.
Colonialidade do saber na internacionalização dos estudos sobre comunicação: abordagem do caso da América Latina
Authors: Torrico Villanueva Erick Rolando
Published: January 2024

Los estudios sobre Comunicación en Latinoamérica se estructuraron por inducción, forma que asumió la internacionalización en este caso. Ello implicó una transferencia canalizada por un grupo de instituciones, así como de profesores, autores y obras que, en general, fungieron como línea de transmisión de la comunicación modernizadora, expresión del espíritu del proyecto civilizatorio moderno cuya episteme se arroga la autoridad sobre el conocimiento válido. Así, esta internacionalización de los estudios comunicacionales a mediados del siglo XX se llevó a cabo bajo la lógica de la colonialidad del saber. Este artículo revisa la trayectoria seguida en ese sentido y se aproxima a una historia de tal proceso.
Uma desordem emocional na escola: saúde mental em termos etnográficos
Authors: Lima Alef
Published: January 2024

O tema da saúde mental ganhou projeção no debate público, principalmente, ao incorporar uma discussão sobre a necessidade competências socioemocionais para vivenciar de modo propositivo o estresse, a frustação e a desigualdade. A proposta de texto é apresentar uma torção etnográfica ao tema, com base em uma experiência de pesquisa ainda em andamento no contexto de uma Escola Estadual de Educação Profissional na zona rural do Ceará. Em termos gerais, a investigação etnográfica visa interpretar o fenômeno da ansiedade (como denominam os/as discentes) na forma de um processo social de identificação, culpa e sofrimento social que se materializa na escola enquanto um palco agentivo de sociabilidade juvenil.
Casas e práticas econômicas nos entornos de um estádio de futebol
Authors: Fernandes Bruno Guilhermano
Published: January 2024

Neste artigo, apresento as principais evidências sistematizadas em uma dissertação de mestrado. Trata-se do trabalho “Entre casas, comércios e temporalidades: uma etnografia de práticas econômicas nos entornos da Arena do Grêmio”. Nele, pesquisei um conjunto de relações que entrelaçam práticas econômicas, casas e temporalidades, nos entornos do estádio do Grêmio FootBall Porto-Alegrense, em Porto Alegre/RS. A pesquisa se insere na interface da antropologia da economia, da casa, da família e parentesco. Ademais, dialoguei com trabalhos que versam sobre temporalidades, espaços urbanos e os significados sociais do esporte.
Documentos na dobra do tempo: dois antropólogos no Haiti dos anos 1940
Authors: Goyatá Julia Vilaça
Published: January 2024

Este ensaio é um conjunto de imagens que traduz uma dupla presença, no espaço e no tempo: a minha, uma antropóloga brasileira dedicada a fazer pesquisa em arquivos no Haiti nos anos 2000, e a de Alfred Métraux (1902-1963), um antropólogo franco suíço que realizou suas pesquisas etnográficas na primeira metade do século passado. Essas imagens, produzidas por mim em um contexto de pesquisa que tinha Métraux como interlocutor, revelam os bastidores da produção de minha pesquisa de doutorado ao mesmo tempo que mostram também os processos pelas quais passaram as pesquisas do próprio Métraux no Haiti.
Criação, água e parentesco: Trajetórias e genealogias da família Negreiros no povoado de Lagoa de Fora, São Raimundo Nonato-PI
Authors: Leal Natacha Simei , Negreiros Luiz Alex Guerra , Miranda Raíssa Barberino , Café Fernanda
Published: January 2024

Este artigo pretende analisar a relação entre os usos e compartilhamento de água e a produção de famílias e parentesco no semiárido piauiense, em um bairro rural chamado Lagoa de Fora – localizado na cidade de São Raimundo Nonato, Piauí. A partir da descrição de estratégias de compartilhamento de água em um ambiente marcado por longos períodos de estiagem e com os aportes teóricos da Antropologia Rural e de uma perspectiva alquímica da produção de parentesco (Marques; Leal, 2018), propõe escrever uma etnografia sobre tecnologias de manejo de água (em barreiros, lagoas, poços, cacimbas, caldeirões, grotas, rios e barragens) e sua indissociável relação com a história de uma grande família, os Negreiros. Pretende mostrar a água, como substância e símbolo, que no semiárido piauiense e em especial em Lagoa de Fora, parece ser constitutiva para a produção de territorialidades, memórias e parentescos.
Zona Autônoma Provisória: ou o estado Fantasma em Madagascar
Authors: Graeber David , Soares Renato Martelli , Braga Leonardo Viana
Published: January 2024

Análise etnográfica do conceito de "Zona Autônoma Provisória" a partir do trabalho de campo de Graeber em Madagascar.
O que as imagens fazem na antropologia?
Authors: Almeida Neto Joaquim Pereira de , Gonçalves Gabriela Lages , Souza Jeferson Bastos de , Macedo Victor Miguel Castillo de
Published: January 2024

Esse dossiê, que reúne ensaios visuais provenientes de diferentes contextos de pesquisa, nos mostra que as imagens, além de fazerem ver, pensar, imaginar, movimentar, analisar e deduzir, materializam presenças e alianças. Os seis ensaios aqui publicados nos colocam diante de variadas formas de abordagem do uso de imagens, trazendo conjuntos de fotografias e de desenhos etnográficos, colagens, diagramas, mapas mentais e imagens de arquivo. Essas visualidades, cada uma a seu modo, permitem refletir sobre os processos de feitura da etnografia, sobre os espaços de intimidade adentrados ou restringidos durante o trabalho de campo, e ainda sobre as estratégias metodológicas usadas para fazer ver ou fazer compreender aquilo que é vivido nos encontros entre pesquisadores e interlocutores de pesquisa.
Uns emaranhados antropológicos
Authors: Gomes Varjão João Victtor , Gómes-Mateus Diana Paola
Published: January 2024

Quando refletimos sobre a antropologia contemporânea é inegável a relevância das novas relações no jogo antropológico, os emaranhados antropológicos. Essas novas relações têm renovado o fazer etnográfico, produzindo uma importante mudança nas clássicas dicotomias da disciplina. Novas sujeições, novas malhas, novas ontologias. Os novos emaranhados fazem emergir outras reflexões e problematizações, apresentado reinvenções criativas e inventivas do fazer antropológico. O segundo número do volume 32 da Revista Cadernos de Campo, a revista de alunas, alunos e alunes do Programa de Pós-Graduação em Antropologia Social da Universidade de São Paulo (PPGAS/USP), reúne um importante conjunto de produções antropológicas contemporâneas, demonstrando a maneira pela qual são as relações que se renovam no fazer etnográfico.
Três questões de Sociologia Clássica: o trabalho em Marx, a moral em Durkheim e a ação social em Weber
Authors: Severo Marconi
Published: January 2024

Este artigo é dedicado à análise de três conceitos fundamentais da Sociologia clássica: o trabalho, em Karl Marx; a moral, em Émile Durkheim; e a ação social, em Max Weber. O objetivo da análise é demonstrar como esses conceitos fundamentaram a construção e impactaram nos futuros desdobramentos do pensamento teórico-metodológico dos referidos autores. É certo que as diferentes concepções sociológicas não se resumem a um único conceito; no entanto, a sua análise permite apreender, ainda que parcialmente, as bases em que se constituíram o que há de mais fundamental na obra de cada um dos referidos autores.
The Effects of Whole-Hand Interactions with One Fingertip Vibrotactile Feedback on Cooperative VR Game Experience and Performance
Authors: Moon Hye Sung , Moon Hayoun , Orr Grady , Jeon Myounghoon
Published: January 2024

New technologies have recently advanced user experiences in virtual reality (VR), whereas full sensation of diverse modalities has been not achieved yet. If any, haptic feedback has been delivered via bulky gloves. We have developed a novel thimble device that can deliver vibrotactile feedback via one fingertip. With this device, in the present study we investigated the effects of interaction methods and vibrotactile feedback on users' social presence, presence, engagement, workload, and performance in a cooperative VR game. Twenty-six participants wearing a VR headset played a cooperative VR game with the experimenter under four conditions: (1) controllers with no vibrotactile feedback, (2) controllers with vibrotactile feedback, (3) hand tracking with no vibrotactile feedback, and (4) hand tracking with vibrotactile feedback. Results showed that hand tracking improved participants' presence, engagement, and perceived workload compared to the traditional VR controllers. Also, vibrotactile feedback enhanced presence. However, the VR controllers outperformed the hand tracking interactions in completion time. The usability of hand interactions with vibrotactile feedback shows a promising result. We discuss the trade-offs between user experience and performance of the interaction methods and the potential of vibrotactile feedback in the VR environment.
The Latin Polycarp, the Division Hypothesis, and Polylingual Text
Authors: Gasse Grant W.
Published: January 2024

Polycarp’s Letter to the Philippians (Pol.Phil.) is poorly attested. All extant Greek manuscripts (G) stem from one source, Vaticanus Graecus 859 (V), which preserves only a portion of the text. Accordingly, editors reproduce G, supplemented as needed with the old Latin translation (L), preserved in its entirety, and with Greek fragments preserved in Eusebius. I argue that L ought to be treated as a discrete witness to the epistle, and not merely as supplement to G. The paper proceeds in two parts: first, I offer a careful analysis of the translation, concluding that L offers a relatively faithful, literal translation and a comparably well-preserved attestation to the epistle. Second, I demonstrate that the well-known “division hypothesis” relies upon an incomplete analysis of L. In short, I contend that the construction of composite, polylingual critical editions of Pol.Phil. has occasioned textual problemata unreflected in the text’s individual manuscript traditions.
Effects of Otago exercise programme and Pilates based exercise to minimise risk of fall in older adult women of the rural population of Haryana
Authors: Kashish B. , Hussain M.E. , Kumar S.
Published: January 2024

Older adults frequently experience falls, which is a serious issue that can have severe effects on both the individual and society. Physiotherapy can play an important role in older persons to avoid falling. The objective of the current study is to evaluate the potential efficacy of Otago exercise and Pilates based exercise for preventing falls. On the basis of inclusion criteria 75 older adult women were randomly assigned into three groups, i.e. Group A (Otago exercise group), Group B (Pilates exercise group) and Group C (Control group). Mobility, fear of fall, activities of daily living, balance and sleep quality were examined at baseline and after 6 weeks of the intervention. Otago exercise group session was administered for 30 min per day, at a frequency of 5 sessions per week, for a period of 6 weeks, whereas Pilates based exercise group session was for 30 min., 3 days/week for 6 weeks. There was a significant difference in time up and go test score (), fall efficacy scale (), Berg balance scale (), whereas no or minimal significant was the Barthel index score (). Sleep quality improved by Pilates based exercise () more than other groups. Main findings of the present study suggest that Otago exercise program improve mobility, activity of daily living, balance, decrease fear of fall and Pilates can be used to improve sleep.