bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of CpG methylation and non-CpG methylation is associate with Lymphocyte specific helicase
Authors: Lai Weiwei , Ouyang Lianlian , Liu Na , Liu Shouping , Shi Ying , Chen Ling , Wang Xiang , Xiao Desheng , Liu Shuang , Tao Yongguang
Published: January 2020

Background : CpG methylation is crucial for normal cell development and differentiation in mammalian genomes, whereas non-CpG methylation presents in stem cells and appears to be enriched in pluripotent cell types. Lymphocyte-specific helicase (LSH) is critical for normal cell development as a regulator of CpG methylation, but whether there is potential link between LSH and non-CpG methylation remains unclear. Results: In this study, we using reduced representation bisulfite sequencing(RRBS), we found that LSH affected DNA methylation patterns in lung adenocarcinoma (LUAD) cells. We analyzed 12,239 differentially methylated regions (DMRs) for CpG methylation and 1605 DMRs for non-CpG methylation. LSH did not change CpG methylation at a global level, but partially change the methylation of CpG islands (CGIs). Interestingly, LSH reduced approximately 30% of CHH methylations at CGIs and consistently decreased CHG and CHH methylation patterns. However, LSH increased the CHH methylation level in satellite and simple-repeat region. The KEGG analysis showed LSH to be linked with a markedly enrichment in focal adhesion and the PI3K-Akt pathway. Further analysis indicated that LSH might epigenetically regulate the binding of transcription factors, including SP2, etc. Conclusions: These findings suggest that LSH have no remarkable influence on CpG methylation but it partially alter non-CpG methylation and repeat sequences in LUAD. LSH inhibits non-CpG methylation in cancer and may function as a regulator to promote tumorigenesis through inhibiting non-CpG methylation.
Addition of Taxanes to Platinum and Fluoropyrimidines in Adjuvant Setting Did Not Improve Survival in Patients with Gastric Cancer after Curative Gastrectomy
Authors: Wu Lili , Wu Zhijun , Xu Hui , Wu Changhao , Zhang Cheng , Feng Ying , Hao Jiqing , Ma Tai
Published: January 2020

BackgroundTo evaluate whether the addition of taxane to platinum and fluoropyrimidines in adjuvant chemotherapy would result in longer survival than platinum plus fluoropyrimidines in patients who underwent curative gastrectomy.MethodsThis study retrospectively analyzed survival for patients with stage Ⅱ-Ⅲ gastric adenocarcinoma who received curative gastrectomy and adjuvant chemotherapy with platinum plus fluoropyrimidines (PF group) or taxanes and platinum plus fluoropyrimidines (TPF group). Survival curves were estimated using the Kaplan-Meier method, and the differences were compared using the log-rank test.ResultsBaseline characteristics were balanced between the PF group and TPF group. The median disease-free survival (DFS) was 14.9 months (95% CI: 11.0-18.8) in the PF group and 13.8 months (95% CI: 9.3-18.3) in the TPF group (HR=0.90, 95% CI: 0.63-1.29, log-rank test, P=0.560). The median overall survival (OS) was 30.0 months for patients in the PF group (95% CI: 24.5-35.5) and 25.6 months (95% CI: 22.3-28.9) for those in the TPF group (HR=0.93, 95% CI: 0.64-1.35, log-rank test, P=0.705).ConclusionFor stage Ⅱ-Ⅲ gastric adenocarcinoma, the adjuvant triple combination of TPF regimen after curative gastrectomy did not demonstrate survival benefit compared to the PF regimen.
Thoracic Endometriosis presented as catamental hemoptysis: Fourteen Cases of a Rare Disease and the hormonal treatment management
Authors: Dai Yi , Li Meng-Hui , Liu Yong-Jian , Liu Bing , Wu Yu-Shi , Lang Jing-He , Zhang Zhen-Yu , Leng Jin-hua
Published: January 2020

Background: Thoracic endometriosis syndrome (TES) is a rare disease in which a functioning endometrial tissue is observed in the pleura, lung parenchyma, airways, or diaphragm. The optimal management of this disease remains a matter of debate Methods: Retrospective study in one university based tertiary care hospital between 1997 to 2017. 14 women presented as CH diagnosed with thoracic endometriosis were included. The main outcome of measure was cessation or recurrence of the clinical manifestations of thoracic endometriosis. Baseline parameters were presented using descriptive statistics. For categorical variables, Pearson’s chi-square tests or Fisher’s exact tests was used as appropriate to describe the characteristic of thoracic endometriosis presented as CH, and the long-term prognosis after hormonal treatment. Results : The mean onset age of the 14 patients was 30.21±5.40 years. Catamenial hemoptysis (CH) was characteristic symptom of these patients, and most of patients (13/14, 92.9%) had regular menstruation and only 42.9% (6/14) of the patients complained of different degrees of dysmenorrhea. All patients underwent chest computed tomography (CT) scan during menstruation and 2 or 3 weeks after menstruation, which showed the obvious shrinking or disappearance of the lesions. No active bleeding on bronchial mucosa were observed in patients with CH, and the bronchoalveolar lavage (BAL) did not find the typical abnormality. All of patients were given GnRH-a for 3 to 6 months, eleven of them were administered with COCs cyclically after GnRH-a. All patients were followed up and the median follow-up duration was 24 months. Hemoptysis recurrence was observed in one patient. Conclusion: CH is a rare clinical entity of thoracic endometriosis, which has the typical cyclic manifestation with menstruation. The change of CT images during and after menstruation or the response to GnRHa were helpful for accurate diagnosis. Hormonal treatment with GnRH-a followed by COCs cyclically could be employed as a choice of therapy for efficient management of thoracic endometriosis.
Fidelity to individual components of a standardized labor induction protocol and association with improved obstetric outcomes: secondary analysis of a randomized controlled trial
Authors: Hamm Rebecca Feldman , Beidas Rinad S , Srin Sindhu K. , Levine Lisa D.
Published: January 2020

Background Standardized labor induction protocols improve obstetric outcomes. However, these protocols are complex. The Consolidated Framework for Implementation Research describes intervention components as “core” and “adaptable periphery.” We aimed to identify core components by investigating the individual components of an evidence-based protocol most associated with effectiveness. We planned to utilize this information to simplify our protocol prior to multi-site implementation. Methods This is a secondary analysis of an RCT comparing time to delivery among four labor induction methods. All patients enrolled in the trial had their labor managed with a multidisciplinary-developed, evidence-based labor induction protocol. For each patient’s induction, we assessed fidelity to 7 components of the protocol. Primary effectiveness outcomes included cesarean delivery, maternal morbidity, and neonatal morbidity. Bivariate analyses assessed association of each component with each primary effectiveness outcome. Multivariable logistic regression determined independent predictors of each outcome while controlling for demographic and clinical factors known to be related to our outcomes. Results The 491 patients enrolled in the RCT were included in this analysis. While multiple components were associated with each outcome in bivariate analysis, few were found to be independent predictors of effectiveness in multivariable analysis. For cesarean delivery, only one component “for women in active labor, all cervical exams were performed ≤2.5 hours apart” was an independent predictor. For maternal morbidity, only one “if an intracervical Foley catheter was utilized for cervical ripening, it was removed within 12 hours of placement” remained significant. For neonatal morbidity, two components “all cervical exams performed in latent labor were performed ≤4.5 hours apart” and “for women in active labor, all cervical exams were performed ≤2.5 hours apart” remained independent predictors. Of the independent predictors of effectiveness, most reflected the overarching concept of “frequent exams in labor will allow for more frequent intervention when no change is made”.Conclusions This study demonstrates a novel strategy to identify which components of an evidence-based intervention should be “core” and which are “adaptable periphery”; this provides valuable information when designing for dissemination and implementation. With an understanding of the relationship between fidelity to individual protocol components and effectiveness, we can systematically simplify interventions prior to large-scale implementation, a potential strategy to increase implementation success. These data will be used to streamline our protocol to best target cesarean rate and maternal/neonatal morbidity prior to a planned type I hybrid effectiveness-implementation trial.
Impact of shift work on the cortisol awakening response and stress: a longitudinal study in female shifting monthly nurses
Authors: Chang Wen-Pei , Jen Hsiu-Ju
Published: January 2020

Background: Although the majority of shift nurses are female, there is still an expectation that they fulfil the traditional role of women in the family, often conflicting with shift work, increases stress, and affects cortisol secretion patterns. This study was to understand the changes in the cortisol awakening response (CAR) and work stress in nursing personnel working in different shifts. Methods: 41 female shift nurses were recruited that fit criteria using purposive sampling. We obtained personal information, administered the Taiwan Nurse Stress Checklist (NSC), and the nurses themselves collected saliva samples upon waking and 30 minutes after waking for three consecutive days at home. We then analyzed the data obtained using a hierarchical linear model. Results: The results revealed that night-shift nurses derived significantly more stress from an inability to complete personal tasks than did day-shift nurses ( B = 4.39, p < .001) or evening-shift nurses ( B = 3.95, p < .001). Night-shift nurses also exhibited significantly lower CARi than did day-shift nurses ( B = -3.41, p < .001) or evening-shift nurses ( B = -2.92, p < .01) as well as significantly lower cortisol levels 30 minutes after waking than did day-shift nurses ( B = -3.88, p < .001) or evening-shift nurses ( B = -3.31, p < .01). Conclusions: This study indicate that female night-shift nurses displayed the lowest CARi and cortisol levels 30 minutes after waking and are more negatively affected by being unable to complete personal tasks.
The relationship between spiritual health and happiness among the students of health Sciences in Guilan University of Medical Sciences
Authors: Kasmaei Parisa , Fattahi Esmaeil , Hassankiadeh Roghaye Farhadi , Almasi Afshin , Ziapour Arash , Kasraei Farzaneh , Rastegar Ayoob , Roodpishi Zahra Ensandoost , Nasirizadeh Mohtaram , Ghasemabadi Mahsa Rostamtabar
Published: January 2020

Background: Spirituality and spiritual health are important concepts among human societies, and the relation of these concepts to other scientific ones is important for health professionals. The purpose of this study is to investigate the relationship between spiritual well-being and happiness among the students of health sciences of Guilan University of Medical Sciences. Methods: This is a cross-sectional and descriptive-analytic study carried out among 322 students through census sampling method. The Spiritual Health Questionnaire (SWBS) was made by Pulotsin and Ellison in 1982 and used to measure spiritual well-being. Oxford Happiness Questionnaire (OHI) was used to measure happiness designed in 2007 by Argyle. Validity and reliability of two questionnaires are higher than 0.90. Cronbach's alpha in each dimension of spiritual well-being and also happiness in the present study was higher than 0.7. Results : The mean and standard deviation of spiritual health were 55.82±4.71 and the mean and standard deviation of students' happiness was 60.88+-12.9. There is no statistical correlation between spiritual health with any of the demographic variables. It means that the average spiritual health is not significantly different at different ages or between single students and married students. Conclusion: The results showed that there is a positive and significant relationship between spiritual well-being and happiness. Also, there is a meaningful relationship between all aspects of spiritual health with happiness. The findings of this research illustrate the happiness is reduced by increasing the average age.
Reversible Long Term Contraceptives Utilization among Married Women of Reproductive Age Group in Areka town, South Ethiopia
Authors: Dake Samson Kastro , Lera Temesgen
Published: January 2020

Background: In low income countries, maternal mortality rate remains high. Bearing many children is the main factor affecting maternal health. This study aimed to estimate the prevalence of reversible long term contraceptives utilization and identify factors associated with it among married women of child bearing age in Areka town in South Ethiopia Methods: We did a community-based cross-sectional survey involving systematically recruited 346 married women of reproductive age group. Data was collected using a structured interviewer-administered questionnaire on May 2019. We used SPSS version 25 for data entry and analyses. Bivariate logistic regression analysis was used to select exposure variables with a crude association. Multivariate analysis was done to control for potential confounders and identify predictors of the outcome. Adjusted Odds Ratio (AOR) with 95% Confidence Interval (CI) was reported and statistical significance was declared at p <0.05.Results: The prevalence of reversible long term contraceptives utilization among married women of reproductive age group was 38.7% in the study area. Utilization of reversible long term contraceptives was positively associated with being Protestant Christian religion follower (AOR=5.33; 95% CI: 1.63, 17.40), advanced educational status (AOR=5.78; 95% CI: 1.97, 17.02), history of abortion (AOR=7.17; 95% CI: 2.81, 18.27), and having a better attitude towards reversible long term contraceptives (AOR=2.85; 95% CI: 1.46, 5.57). Whereas, being a housewife (AOR=.27; 95% CI: .09, .79) and daily laborer (AOR=.14; 95% CI: .02, .80), having no radio in the household (AOR=.40; 95% CI: .16, .99) and making fertility decisions alone (AOR=.12; 95% CI: .04, .37) were negatively associated. Conclusion: Women should be empowered educationally through other alternative opportunities to school. On top of electronic media, other alternative media should be used to convey messages on contraceptives particularly RLTCs. Behavioral change communications would benefit women in shaping their attitudes towards RLTCs.
Healthcare Providers’ Knowledge and Their Perceived Factors Influencing Cancer Palliative Care Services in Kwazulu-natal
Authors: Dlamini Minenhle , Hlongwana Khumbulani W. , Ginindza Themba G.
Published: January 2020

Background: Healthcare providers spend most of their time in direct care of critically ill patients. The family members of the critically ill patients are not spared from managing physical, psychological, emotional and spiritual symptoms, yet many of them feel anxious and unprepared to care for palliative patients. The purpose of this study was to determine healthcare providers’ knowledge and perceived factors influencing cancer palliative care (PC) services in the selected sites of Durban and Pietermaritzburg, KZN. Methods: This was a mixed methods study using a structured questionnaire and focus group discussions (FGDs) for quantitative and qualitative aspects, respectively. All healthcare providers were selected through convenience sampling, based on being relevant to the study objectives. Twenty-seven healthcare providers participated in structured questionnaires with eight being further selected to participate in an FGD based on being information-rich. IBM SPSS Statistics (v.25) and NVIVO 12 Pro software were used to analyze quantitative and qualitative data, respectively. Results: The mean (+SD) age of the 27 participants was 42.52 (+11.37) years and about 48.1% were within the age-group 31–40 years. The majority of participants were females (77.7%) and were married (59.5%). More than four-fifths (81.5%) had attended up to tertiary level as the highest level of education, 85.1% were permanently employed and 96.3% were from urban areas. The majority of participants had been trained in PC (70.4%), 55.5% had less than five years’ experience working as palliative healthcare providers and 51.8% rated their experience of caring for cancer patients as good. Perceived barriers in patients seeking PC, included three themes, namely: (1) effects of intra-departmental collaboration, (2) caregivers’ perspectives regarding the complexities of PC seeking barriers and (3) innate factors that sustain the community caregivers’ motivation. Conclusion: Healthcare providers trained and/or implementing PC have varying levels of competencies, suggesting a need for continuous professional development (CPD) to build PC skills. The results also provided clear evidence that collaboration among the stakeholders within the Department of Health can potentially enhance PC service delivery in KwaZulu-Natal.
Evaluation in the first level of care of patients with type 2 diabetes and their risk of hospitalization in Mexico
Authors: Fernández-Gárate José Esteban , Manuel-Apolinar Leticia , Zurita-Cruz Jessie N. , Acevedo María de Lourdes Basurto , Flores María Luisa Arellano , González Roberto Alejandro Correa , Cisneros Nelly Gonzalez
Published: January 2020

Background: A significant body of international evidence suggests that effective primary care systems are associated with better health, lower total health costs, and more equitable access to health care services, which has led the World Health Organization (WHO) to call for strengthening primary care systems globally. Patients with diabetes often seek treatment and have follow-up as outpatients, be it at private or government health facilities. Thus, the objective of this study was to assess the effect of glucose control during outpatient care on first hospitalization risk in type 2 diabetes mellitus (T2DM) patients.Methods: The data used in this retrospective cohort study were obtained from the Non-Communicable Diseases Analysis System (SANENT)® of the Instituto Mexicano del Seguro Social (IMSS). Thus, this work was performed on 3,716,031 DM2 patients, with data regarding a first hospitalization risk estimated using a Cox regression model.Results: The first hospitalization crude risk for diabetes mellitus decreased by 32% in T2DM patients under control through outpatient care (HR: 0.68, 95% CI [0.68,0.69]). Adjusted risk decreased by 23% (HR: 0.77, 95% CI [0.76, 0.77]).Conclusion: The obtained results are consistent with what has been stated in the literature. Outpatient care of diabetic patients at the IMSS should be further strengthened by means of preventive and educational strategies and supported by technology.
РУХОВА АКТИВНІСТЬ – ОСНОВА ФІЗИЧНОГО ЗДОРОВ’Я
Authors: Тисевич Т. В. , Лойко Є. Є.
Published: January 2020

Резюме. Стаття відображає рівень рухової активності студентів першого курсу медичного факультету Вінницького національного медичного університету ім. М.І. Пирогова. З цією метою проанкетовано 230 “практично здорових” студентів (140 дівчат та 90 юнаків) віком від 17 до 22 років. Респондентів поділено на дві групи: до першої групи віднесено 93 студенти-медики (52 дівчат та 41 юнак), які проживають у місті Вінниця, а до другої групи – студенти з Вінницької області в кількості 137 чоловік (88 дівчат та 49 юнаків).
Проведене опитування встановило, що 2% юнаків професійно займаються спортом; 23,5% юнаків та дівчат – фізичними вправами; щоденні прогулянки мають 44,5% студентів; сидячий спосіб життя веде значна частина студентів – 30%. Відрізняється фізична активність залежно від статі, зокрема, вона слабша у дівчат. Рухова активність за добу у 22% студентів менше 1-єї години; 1-2 години за добу – 39,5%; 2-3 години за добу – 25,5%; 3-4 години за добу – 10% і більше 4 годин за добу лише у 3% студентів. Під час перерв більшість студентів готуються до наступної пари (45%) або відпочивають пасивно (44%). Вільний від навчання час студенти проводять за переглядом телепередач, мережі Інтернет – 45,7%; за малюванням, в’язанням, настільними іграми – 18,6%; наукові гуртки відвідує 5,7% молоді; за фахом працює 4,8% студентів та 25,2% юнаків та дівчат надають перевагу спортивним заняттям. Гіподинамія більш поширена серед юнаків та дівчат, які приїхали на навчання з Вінницької області.
Отже, виявлена низька рухова активність серед студентів-медиків. Саме тому варто приділяти велику увагу виховним процесам, прищеплюючи студентам культуру здорового способу життя з вектором на підвищення рухової активності.
ЗАСТОСУВАННЯ СУЧАСНИХ ПІДХОДІВ ДО ВИКЛАДАННЯ ОСНОВ ОНКОГЕНЕТИКИ ДЛЯ СТУДЕНТІВ-МЕДИКІВ
Authors: Кіцера Н. І.
Published: January 2020

Резюме. Глобалізаційні процеси в сфері модернізації якості освіти та навчання зумовлюють потребу удосконалення та застосування новітніх підходів до викладання та подачі матеріалу студентам-медикам. В умовах стрімкого зростання онкологічних захворювань назріла необхідність створення інтегрованих підходів до методології ведення практичних та теоретичних дисциплін задля успішного проведення навчального процесу, який дозволятиме підготувати фахівців медичної сфери, зокрема в галузі онкології та онкогенетики. Необхідна інтеграція викладання онкогенетики на теоретичних кафедрах і створення цілісної наскрізної програми з подальшим продовженням на клінічних базах.

У статті проаналізовано основні сучасні інструменти щодо викладання основ онкогенетики для студентів-медиків з метою розроблення цілісної системи її викладання в Івано-Франківському національному медичному університеті.

Ефективність та результативність організації професійної підготовки майбутніх медиків з онкогенетики залежить від форм і засобів освітнього процесу. Застосування інтерактивних методів навчання (ділова рольова гра, створення відеофрагментів, методики Пазли тощо) допомагають при формуванні професійних компетентностей студентів-медиків з основ онкогенетики.

Перспективи майбутніх досліджень полягають у створенні методичних рекомендацій з інтеграції викладання основ онкогенетики на всіх кафедрах університету, проведенні комплексних лекцій для студентів із залученням різних спеціалістів, ширшому впровадженні сучасних інноваційних методик викладання студентам медичних спеціальностей дисциплін в сфері онкогенетеки.
ВАЗОМОТОРНА ФУНКЦІЯ ЕНДОТЕЛІЮ У МОЛОДИХ ОСІБ РІЗНОГО СОМАТОТИПУ З НОРМАЛЬНИМ ТА ПІДВИЩЕНИМ АРТЕРІАЛЬНИМ ТИСКОМ
Authors: Вадзюк С. Н. , Горбань Л. І. , Папінко І. Я.
Published: January 2020

Резюме. Мета роботи – оцінити вазомоторну функцію ендотелію у молодих осіб віком 18-22 роки різного соматотипу з нормальним та підвищеним артеріальним тиском (АТ).

Матеріали і методи дослідження. Відібрано дві групи обстежуваних: перша контрольна група – особи, у яких величина АТ відповідала оптимальному рівню (125 осіб), друга група – систолічний АТ перевищував 130 мм рт. ст. і (або) діастолічний – 85 мм рт. ст. (135 осіб). Соматотип визначали за методикою Carter i Heath, яка рекомендована для осіб обох статей віком від 14 до 70 років. Соматотипування полягає у визначенні трьох компонентів: ендоморфія, мезоморфія та ектоморфія, які виражаються завжди в тому ж порядку. Оцінку вазомоторної функції ендотелію проводили за допомогою проби з постоклюзивною реактивною гіперемією, згідно з методикою Рогози та Заірової (2011).

Результати. Встановлено збільшення частоти розвитку дисфункції ендотелію у молодих осіб, у соматотипі яких переважав ендоморфний компонент. Це може бути пов’язано із зменшенням продукції оксиду азоту, що зумовлює дисбаланс між вазоконстрикторами і вазодилятаторами. Зниження концентрації оксиду азоту у цих осіб може бути спричинено зменшенням активності NO-синтетази (NOS).

Висновки. У молодих осіб з підвищеним артеріальним тиском та переважанням ендоморфної складової в соматотипі встановлено зниження вазомоторної функції ендотелію, що вказує на зменшення синтезу оксиду азоту ендотеліальними клітинами, що може бути спричинено як конституційними характеристиками, так і особливостями способу життя цих осіб. Серед осіб із нормальним артеріальним тиском та з переважанням ендоморфної складової соматотипу також виявлено зниження вазомоторної функції ендотелію, проте відсоток таких обстежених був істотно нижчим, порівняно із групою підвищеного артеріального тиску.
ВПЛИВ ВЕСТИБУЛЯРНОГО НАВАНТАЖЕННЯ НА СИСТЕМУ КРОВООБІГУ ЗА РІЗНИХ ТИПІВ ПОГОДИ
Authors: Вадзюк С. Н. , Шмата Р. М. , Лозіна Л. Б.
Published: January 2020

Резюме. Дослідження функціональної активності вестибулярного аналізатора мають важливе значення, оскільки він не тільки контролює положення тіла в просторі, забезпечує його рівновагу, але й приймає участь у регуляції функціонування інших систем організму.

Мета дослідження. Оцінити вплив вестибулярного навантаження на функціональний стан системи кровообігу за різних типів погоди для визначення у майбутньому показів до метео-профілактики.

Матеріали і методи. Визначали величину артеріального тиску та частоту серцевих скорочень до та після вестибулярного навантаження, на основі яких оцінювали вестибулярну стійкість при І та ІІІ типах погоди.

Результати дослідження та їх обговорення. При І типі погоди в осіб із відмінною вестибулярною стійкістю ми спостерігали незначне підвищення показників систолічного і діастолічного АТ та ЧСС, що при оцінці вестибулярної стійкості за методикою Н.Н. Лозанова і І.П. Байченка дорівнювало в середньому 4,8 бали. При ІІІ типі погоди в осіб, які не відмічали проявів вестибулярної дисфункції, ми спостерігали тенденцію до зниження вестибулярної стійкості. В осіб із достатньою вестибулярною стійкістю та недостатньою вестибулярною стійкістю, при І типі погоди середня вестибулярна стійкість дорівнювала 2,8 бали, що супроводжувалось більшою зміною величини АТ та ЧСС. При ІІІ типі погоди кількість осіб із недостатньою вестибулярною стійкістю значно збільшилась, а саме: у 57 % осіб, у яких при першому типі погоди показник вестибулярної стійкості дорівнював рівню «достатня стійкість», при ІІІ типі він знизився до рівня «недостатня вестибулярна стійкість».

Висновки. Оцінюючи відповіді системи кровообігу на вестибулярне навантаження при І і ІІІ типах погоди, встановили зниження вестибулярної стійкості при ІІІ типі погоди порівняно з І.
Editorial
Authors: Pereira Íris Susana Pires , Martinho Maria Helena
Published: January 2020

Editorial
The Role of Human Capital in Improving the Quality of Insurance Service
Authors: Abu Tabikh Laith Shakir
Published: January 2020

The Sought current research aim to determine the nature of the relationship between human capital with its dimensions (knowledge, ability, skill) and quality insurance service with its dimensions (reliability, responsiveness, tangibility, safety, communication, courtesy), which was done by analyzing the correlations and influence between the variables research, and applied to a random sample of the staff of a number of branches of both (national insurance and Iraqi company) in the Middle Euphrates, with number of (89) employees, hypotheses were tested using Pearson's correlation coefficient linear regression and (F) test using software of (SPSS V.20). In the light of the results, a set of the most important conclusions were such as, there is a positive effect of human capital in improving the quality of the insurance service, the research presents a number of recommendations, such as giving the consideration to human capital by insurance companies as a strategic resource that gives it a competitive advantage.
What´s driving dermatology: Contribution title analysis of the largest German Dermatology Congress 2019 (Preprint)
Authors: Kaczmarczyk Robert , Bauerdorf Felix , Zink Alexander
Published: January 2020

BACKGROUND

Every two years, German-speaking dermatologic specialist groups gather in Berlin to share the latest developments at Germany´s largest dermatologic conference, the Annual Meeting of the Germany Society of Dermatology (DDG). Because this conference has a lasting effect on dermatologic practice and research, understanding what is moving the specialist groups means understanding what is driving dermatology in Germany.

OBJECTIVE

The objective of the article is to introduce the medical scientific community to a data visualization method, which will help understand more sophisticated data analysis and processing approaches in the future.

METHODS

We used word network analysis to compile and visualize the information embedded in the contribution titles to the DDG Annual Meeting in 2019. We extracted words, contributing cities and inter-connections. The data was standardized, visualized using network graphs and analyzed using common network analysis parameters.

RESULTS

A total of 5509 words were extracted from 1150 contribution titles. The most frequently used words were “therapy”, “patients”, and “psoriasis”. The highest number of contributions came from Hamburg, Berlin and Munich. High diversity in research topics was found, as well as a well-connected research network.

CONCLUSIONS

Focus of the well-connected German-speaking dermatology community meeting 2019 was patient and therapy centered and lies especially on the diseases psoriasis and melanoma. Network graph analysis can provide helpful insights and help planning future congresses. It can facilitate the choice which contributors to include as imbalances become apparent. Moreover, it can help distributing the topics more evenly across the whole dermatologic spectrum.
Cost–effectiveness analysis of intravitreal aflibercept in the treatment of diabetic macular edema in China
Authors: Ming Jian , Zhang Yabing , Xu Xun , Zhao Mingwei , Wang Yusheng , Chen Youxin , Zhang Feng , Wang Jiawei , Liu Jun , Zhao Xinran , Han Rong , Hu Shanlian
Published: January 2020

Aim:
To evaluate the cost–effectiveness of intravitreal aflibercept compared with macular laser photocoagulation and ranibizumab for diabetic macular edema (DME) in China.
Methods:
A Markov model was developed to reflect the vision changes in DME patients. Parameters were estimated from VIVID-EAST trial data, published literature and physician surveys.
Results:
In a 20-year horizon, intravitreal aflibercept was associated with 7.825 quality-adjusted life years (QALYs) and 217,841 Chinese Yuan Renminbi (CNY), laser photocoagulation was associated with 7.189 QALYs and 135,489 CNY, and ranibizumab was associated with 7.462 QALYs and 222,477 CNY. The incremental cost–effectiveness ratios were 129,397 CNY/QALY and -12,774 CNY/QALY for intravitreal aflibercept versus laser photocoagulation and ranibizumab, respectively.
Conclusion:
Intravitreal aflibercept was considered as a cost-effective strategy for DME when compared with laser photocoagulation; it was considered as a dominant strategy when compared with ranibizumab.
Análisis del tiempo de ascenso de pasajeros en buses de la ciudad de Bogotá usando un diseño factorial
Authors: Espejo Fandiño Fredy Leandro
Published: January 2020

Mediante un estudio comparativo por observación se analizan en un diseño factorial los tiempos de ascenso por pasajero en rutas urbanas de la ciudad de Bogotá. A través de mediciones en terreno de los tiempos de detención de los buses en distintos paraderos de la ciudad, dando prioridad a los casos donde suceden ascensos de usuarios exclusivamente, dos tratamientos fueron involucrados en el experimento, la tipología vehicular con tres niveles (bus pequeño, bus mediano y bus grande) y la ocupación del bus con dos niveles (pocos y muchos pasajeros de pie). Se encontró que los datos originales no siguen una distribución normal y por tanto la variable respuesta fue objeto de transformación para estabilizar la varianza. Sobre los datos transformados, mediante un análisis de varianza de dos factores, se probó que tanto las diferentes tipologías vehiculares que operan en el transporte público de la ciudad como la ocupación del bus, tienen efectos en el tiempo de ascenso por pasajero. Con comparaciones múltiples se encontró que los buses pequeños, para bajos y altos niveles de ocupación, presentan tiempos de ascenso por pasajero significativamente diferentes en comparación con los buses medianos y grandes, y que la ocupación del bus genera diferencias significativas en la variable respuesta sólo para el bus mediano y grande. El modelo resultante fue un diseño factorial sin interacción el cual produjo una explicación del 46% de variabilidad de los datos transformados
Awareness of the Association between Periodontal Health and Diabetes Mellitus among Middle-Aged Population in Burridah, Saudi Arabia
Authors: Dr. Alanood Alzogibi  , Dr. Fares Al-Shubrumi  , Dr. Sumona Bhattacharjee  , Dr.Vivek Prabhu
Published: January 2020

The  link  between  diabetes  mellitus  and  periodontal  diseases  has  been  well-established.  But  there  is  a  lack  of awareness in comparison with other systemic complications. This study aims to assess the awareness of the association between diabetes mellitus and periodontal diseases in a high risk group of population and to identify the important factors which influence this  knowledge.  The  study  was  a  cross  sectional  survey,  which  selected  248  individuals.  The  inclusion  criteria  were  the attendants of Outpatients clinic who were aged = 40 years old, while patients with mental illness were excluded. Data were collected  by  interviewing  patients  using  a  questionnaire  with  closed-ended  questions  in  three  sections.  The  first  section contained questions about characteristics of the study respondents; the second section had questions on clinical examination, and the third section contained questions about knowledge of the effect of diabetes on periodontal health. For sections 1 and 2 of  the  questionnaire,  the  descriptive  statistics  of  frequencies  and  percentages  was  calculated  and  presented  in  frequency distribution tables. The associations between certain demographic and clinical characteristics were presented in crosstabs and the significant differences were detected using chi-square test at 0.05 alpha level of significance. Out of 284 periodontal patients recruited in this study, 67.3% was female and 32.7% was male with majority of the respondents (about 64%) aged 40-50 years old. About 55% had diabetes mellitus and about 66% of them had a family member diagnosed with diabetic mellitus. About 46% of the respondents were aware of the relation between diabetes and gum health. A half of the respondents reported the escalating risk of periodontal diseases among diabetic patients. This awareness was found significantly associated with women of high educational level, positive familial history of diabetes, and number of physician visits. There is lack of awareness of the impact of diabetes on periodontium health in high risk and middle-aged group of general population.
Prevalence and Determinants of Needle stick Injury among Nurses
Authors: Arwa Ahmed Al-Mowaraie  , Sulafa Al-Qutub  , Naif Abdulaziz Al-Harbi
Published: January 2020

Needle stick injuries pose a serious risk of transmission of fatal diseases to the workers of the Health care. Globally, more of the reported cases of needle stick injuries happen among nurses than other health professionals. Our aim is to explore the prevalence of needle stick injuries and determinants  among nurses for better prevention and control. This is a cross- sectional study where we recruited 282 nurses working at King Fahd Hospital in Jeddah city. The validated self-administered questionnaires were distributed by the head nurse to the participating nurses who were in a direct contact with the patients. From  questionnaires  we  investigated  demographics,  work-related  factors,  determinants  of  needle  stick  injuries  and  safety measures. Results of our study showed that about 92% of nurses were females and about 80% regularly take care of 10 patients or less. This study reported a lifetime occurrence of needle stick injury among nurses to be 37.6% (95% CI = 31.9% to 43.3%). The syringe needle was the most common item which caused the recent NSIs among the affected nurses (78.3%), followed by intravenous catheter and tapping needle with prevalence of 11.3% and 7.5% respectively. The occurrence of needle stick injury could not be predicted by nurses’ characteristics such as years of experience, educational level, hours of working and number of patients on duty. However, training on NSIs prevention, Hepatitis B virus vaccination status and availability of safety box in their work place were significant predictors. We conclude that despite the high level of training, awareness, and availability of safety precautions, more than a third of nurses in the KFGH were affected by needle stick injury. Training on NSIs prevention and availability of safety box in their work place were the major determinants of the needle stick injury in KFGH.
A destradicionalização da arte
Authors: Costa Rachel
Published: January 2020

Proponho repensar as modificações da arte nos dois últimos séculos pelo viés da refutação de seus pressupostos tradicionais, i.e., pelo viés da destradicionalização. Esse processo de refutação desemboca no que é chamado hoje de arte contemporânea, a qual possui enquanto característica primeira o pluralismo.
Peningkatan Mutu Produktivitas Aneka olahan Nanas Pada UMKM Nanas di Desa Tangkit Baru: Strategi Penanggulangan Karhutla
Authors: Yuliusman Yuliusman , Setiawan Dedy , Hasbullah Husni , Fitri Lucky Enggrani
Published: January 2020

Sasaran pengabdian ini, adalah Usaha Mikro Kecil Menenggah (UMKM) di Desa Tangkit Baru yang mana pada saat ini memiliki permasalahan dalam hal pemasaran khususnya kesulitan dalam pemasaran produk olahan Nanas. Pengabdian ini, berupaya untuk memberikan pelatihan dalam hal pemasaran dan membuatkan media pemasaran berbasis web atau yang dikenal dengan E-Commerce untuk Mitra. Tujuan dengan adanya pengabdian ini, diharapkan bisa memperkenalkan produk-produk olahan nanas mereka lebih luas lagi melalui web dan dapat meningkatkan Omzet UMKM mitra.Peningkatan omzet ini diharapkan dapat menjadi magnet bagi masyarakatdi desa Tangkit Baru untukdapat meningkatkan kesejahteraan masyarakat di desa tersebut serta dapat mengubah kebiasaan petani di desa tersebut untuk menjadikan hasil pertaniaan mereka menjadi produk olahan dan juga diharapkan dengan kegiatan ini, akan mengubah kebiasaan petani di sana agar kedepannya menjual hasil perkebunan nanas dalam bentuk produk olahan sehingga dengan perubahan ini, tidak ada lagi petani yang ada disana membuka lahan yang baru yang bisa berdampak pada kebakaran lahan dan Hutan.
Internet of Things Smart Agriculture on ZigBee: A Systematic Review
Authors: Hidayat Taufik
Published: January 2020

Teknologi WSN kini semakin meningkat diakhir-akhirnya dan banyak diterapkan diberbagai bidang. Salah satu dari penerapan WSN seperti pada Agiculture yang berbasis Internet of things. WSN ini contoh seperti ZigBee, penerapan ZigBee pada Agiculture sangat membantu pada berbagai bidang Agiculture dimulai dari system control irigasi, pemantauan iklim pada Agiculture serta pengendalian system control rantai makan pada system Agiculture. Internet of things ini mendukung system Agiculture untuk memberikan komunikasi pada sensor-sensor yang ada di Aguculture ini. Sistem Agiculture ini diharapkan bisa meningkatkan produktivitas maupun prediksi masalah yang ada di system pertanian. Systematic riview ini memberikan gambaran bahwa teknologi Internet of things di Agiculture sangat berpontensi baik karena dapat meningkat para petani dalam operasional produksi pangan maupun ternak.
A FORMAÇÃO DOCENTE EM LEOPOLDINA/MG: INTERLOCUÇÕES COM AS REFORMAS DE ENSINO (1906-1918)
Authors: De Oliveira Paloma Rezende , Da Costa Nailda Marinho
Published: January 2020

Este artigo apresenta uma investigação sobre a formação de professores oferecida pelo Ginásio Leopoldinense, situado em Leopoldina/MG, durante o período de 1906 a 1918. Em 1906, esta instituição educacional foi fundada e destacou-se das outras escolas criadas no município, por oferecer muitos níveis de educação: ensino primário, agrícola, secundário, militar e superior em Odontologia e Farmácia. A maioria destes cursos funcionou até meados de 1926, quando esta instituição privada foi municipalizada. Os cursos tiveram um caráter claramente seletivo, tanto no sentido social como no pedagógico e no profissional. Os alunos vieram de classes sociais abastadas, em geral, os filhos de agricultores e profissionais liberais, sendo recrutados desde o ensino primário, preparatório, até os cursos superiores. A partir daí, buscamos evidências que ajudaram na inteligibilidade de como as práticas educativas orientaram o programa de ensino e os atores que construíram esta instituição. Desse modo, a rede de sociabilidade e as carreiras profissionais ajudaram a pensar o programa institucional e sua relação com as políticas locais, estaduais e nacionais. Este, por sua vez, foi analisado do ponto de vista dos autores: Carvalho (2006), Mendonça et al (2015), Bonato (2002; 2009), Nóvoa (2017) e Dubar (1997; 2012), os quais trouxeram contribuições para a análise do Ginásio Leopoldinense, na qual pode-se revelar detalhes da legislação e das reformas educativas, bem como da formação, profissionalização e construção da identidade docente.
“O FEMINISMO TRANSBORDA”: DOCÊNCIA, PRODUÇÃO ESCRITA E ATUAÇÃO POLÍTICA DE AUREA CORRÊA NA CIDADE DO RIO DE JANEIRO
Authors: Rizzini Irma , De Schueler Alessandra Frota Martinez
Published: January 2020

A proposta do artigo é analisar as perspectivas produzidas por uma professora primária municipal do Rio de Janeiro, Aurea Corrêa Villares Ferreira/Martinez, a partir da leitura de sua produção escrita publicada em jornais de grande circulação à época, especialmente a Gazeta de Noticias. O estudo se insere em pesquisa mais ampla sobre a trajetória de professoras e sua participação nos movimentos de luta por direitos civis, políticos e no mundo do trabalho, entre os séculos XIX e XX. A pesquisa realizada sugere que Aurea Corrêa constituiu ampla rede de sociabilidade, baseada nas suas experiências no magistério primário e nas lutas políticas. Atuou na defesa dos direitos dos/as professores/as, na melhoria das escolas e dos métodos de ensino, na propaganda do socialismo e nas eleições presidenciais de 1910. Participou da criação da Associação Escola Moderna, responsável pela fundação de uma escola no centro do Rio de Janeiro, inspirada nas experiências de educação libertária de Francisco Ferrer desenvolvidas em Barcelona. Única conferencista do sexo feminino a integrar os eventos de difusão da iniciativa, defendeu publicamente o ensino racional para as mulheres. Os indícios de sua trajetória retratada neste artigo, e de outras professoras de seu tempo, evidenciam a ocupação de diversos espaços possíveis a algumas mulheres, ao menos àquelas pertencentes aos meios letrados. Suas lutas relativizam a representação corrente sobre o suposto predomínio do mundo doméstico como limite para as experiências femininas naquele contexto histórico.
ARACY CÔRTES E AS EXPERIÊNCIAS EDUCATIVAS DIFUSAS NOS PALCOS AMADORES DO RIO DE JANEIRO (1900-1920)
Authors: Pinto Rebeca Natacha De Oliveira
Published: January 2020

A partir da trajetória de Zilda de Carvalho Espindola (1904-1985), também conhecida como Aracy Côrtes, este trabalho se propõe a compreender as profundas relações entre educação – e suas práticas difusas –, cultura e política na cidade do Rio de Janeiro, nas primeiras décadas do século XX. Através de periódicos, entrevistas concedidas ao Serviço Nacional de Teatro e sua biografia, publicada em 1984, por Roberto Ruiz, busco perceber como as experiências dessa atriz, cantora e empresária do teatro de revista dialogavam com as transformações sociais ocorridas na capital federal. Debruçaremos-nos, especialmente, sobre suas vivências na Sociedade Dramática Particular Filhos de Talma, visto que os grêmios dramáticos vinculavam-se como espaços de formação social, promovendo práticas de letramento, palestras, encontros e debates de textos teatrais que permeavam o cotidiano da cidade. Para tanto, é importante concebermos a educação de forma ampla e plural, entendendo como as iniciativas pautadas em uma ação institucionalizada coexistiram com espaços plurais de acesso às letras. Como nos sugere Edward P. Thompson, ao considerarmos as diferentes vivências de Aracy Cortez no universo do entretenimento carioca, nos inclinamos a olhar para a sociedade na sua multifacetada rede de relações. Não obstante, o início de sua carreira artística nos permite perceber como as mulheres tornaram-se protagonistas de ações educativas, elaborando variadas estratégias para ampliar o acesso ao código letrado, conferindo-lhe uma vasta gama de sentidos.
BLENDED LEARNING, INNOVATIVE PATTERN IN TEACHERS PROFESSIONAL DEVELOPMENT IN EDUCATIONAL SYSTEM OF IRAN
Authors: Fannakhosrow Mahboubeh , Nourabadi Soolmaz
Published: January 2020

O desenvolvimento das TIC e a aplicação de novos instrumentos e conceitos por meio da comunicação on-line, oferecem oportunidades incomparáveis para troca rápida de informações e interações sociais para os alunos e causam expansão da informação, acesso fácil, rápido e de baixo custo. A instituição de ensino, como guardiã da educação e do treinamento, pode ser responsável pela produção de conhecimento e eficiência no processo educacional, aumentando assim o conhecimento de alunos e professores. Portanto, este estudo tem como objetivo combinar o aprendizado eletrônico com o aprendizado tradicional e fornecer aprendizado combinado no desenvolvimento profissional dos professores. Como a missão mais importante da educação é a capacitação de recursos humanos capaz e eficiente, recomenda-se o uso de estudos e experiências anteriores e, contando com a cultura e as fontes indígenas, deve responder a essa pergunta se o aprendizado combinado pode ser usado como um padrão inovador no desenvolvimento profissional dos professores no sistema educacional do Irã. Para responder a essa pergunta, a presente pesquisa foi realizada com o método descritivo-analítico. Agora, com o uso da moderna tecnologia da informação e comunicação, além dos tutoriais virtuais on-line, simultânea ou não-simultânea, é formado um novo tipo de treinamento, o Blended Learning, que é combinado às salas de aula tradicionais e refere-se ao território onde tradicional e eletrônica o aprendizado é usado tanto para treinar os alunos. Usando a Internet e os sistemas multimídia, uma variedade de ferramentas pode ser fornecida para melhorar a qualidade da aprendizagem e também o acesso rápido e fácil aos recursos de informação e, com atividades presenciais, podem ser preparados elementos de interação no treinamento. Assim, com a ajuda das tecnologias e da mídia digital e da criação de um currículo centrado no aluno, a concepção de casos, ensino, aprendizagem, avaliação e avaliação no ambiente de aprendizado eletrônico será otimizada. Uma das necessidades dos sistemas educacionais na era da informação é o cultivo de professores sábios e atenciosos em instituições de treinamento de professores que são competentes para resolver problemas modernos da educação e inovar soluções criativas. O topo da forma para esse fim, o aprendizado misto (baseado em rede) por meio de novos métodos de treinamento, fornece a base necessária para melhorar a qualidade da educação e o treinamento de professores sofisticados e fornece uma maneira eficaz de alcançar as metas proeminentes da educação. A instrução combinada mudou as oportunidades educacionais e as ferramentas práticas também estão disponíveis para professores e designers de instrução.