bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of serum levels of anti-gliadin (IgA and IgG) antibodies in patients with lichen planus: A pilot study
Authors:   Department of Dermatology & Venerology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Al-Zanqaly Shaimaa
Published: October 2023

elevated AGA levels have been reported in several immune-mediated cutaneous conditions even in the absence of gastrointestinal disease clinical manifestations. A gluten-free diet led to improvements in some of these disorders. The link between oral lichen planus (LP) and CD was revealed, but there is currently no information available regarding the association between cutaneous LP and gluten sensitivity. This study aimed to assess the AGA (IgA and IgG) serum levels in LP patients compared to controls and to determine their correlation with LP severity. The study included 20 patients with cutaneous LP and 20 age- and sex-matched controls, both free of CD manifestations. The enzyme-linked immunosorbent assay (ELISA) technique was utilized for the evaluation of AGA (IgA and IgG) serum levels. Hepatitis C virus (HCV) antibodies in LP patients were evaluated qualitatively using a chromatographic immunoassay. In LP patients, AGA (IgA and IgG) serum levels were significantly elevated compared to controls (p = 0.015 and p=0.016, respectively). A significant positive correlation between AGA (IgG) serum levels and the age of patients (p= 0.024), duration of disease (p= 0.02), and LP severity index (p< 0.0001) was found. AGA serum levels were insignificantly different between HCV-positive and HCV-negative LP patients (p= 0.054). In conclusion, the significant elevation of serum AGA levels in LP patients reflects a possible link between LP and occult CD. Serum AGA (IgG) levels can be used as a marker of LP severity..
COVID-19 anti immunoglobulin G antibodies serum levels among health care workers post COVID -19 vaccination: A single center study
Authors:   Department of Endemic & Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Saad Sara
Published: October 2023

Coronavirus disease 2019 (COVID-19) pandemic has urged the scientific community internationally to find answers in terms of therapeutics and vaccines to control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The post vaccination immune response differs between individuals especially health care workers who are the first line of defense to combat this disease. Our aim was to measure levels of anti-IgG antibodies titer post COVID-19 vaccination among health care workers in Suez Canal University Hospital. The study included 141 healthcare workers. Of these, 54 were physicians, 80 nurses, 6 health service workers, and one security guard. We used the Roche Elecsys Anti-SARS-CoV-2 assay for serological detection of IgG. Seropositive was found in 96.5% of the participants, and 43.3% of them had evidence of the prior history of COVID-19 infection. The highest titers of IgG in sera were found in the youngest age groups (20 – <35) years with a mean of 335.1 U/ ml. Participants who received the Sinovac vaccine had the highest mean IgG titer, 354.6U/ml; followed by Sinopharm (mean 352.15 U/ml) then Pfizer and Moderna (311.7U/ml) and AstraZeneca vaccine had the least mean level (267.31U/ml). Fatigue was the most significant short side effect occurring with 34% of the participants. In conclusion, there was a significant rising in serum IgG titer post-vaccine, and better antibody response in those previously infected with COVID-19. The post-COVID-19 vaccine serum IgG titers were affected by age, prior history of COVID-19 infection, and type of vaccine while short side effects post-vaccination may be affected by age and type of the vaccine.
CTH1/TH2 repolarization in induction of immune tolerance to non-steroidal anti-inflammatory drugs during the management of sickle cell disease vaso-occlusive crisis
Authors:   Félix Houphouet Boigny University-Medical sciences–Immunology Allergology Department, Université of Cocody, Abidjan, Côte d’Ivoire., Romualde Dasse ,   University Hospital of Cocody, Abidjan, Côte d’Ivoire.
Published: October 2023

Respiratory manifestations related to the intake of non-steroidal anti-inflammatory drugs (NSAIDs) during the treatment of the painful vaso-occlusive crisis of sickle cell disease are either a type I hypersensitivity mechanism of the Gell and Coombs classification, or a pharmacological mechanism of NSAIDs. The use of NSAIDs is essential in the Abidjan school because of the absence of therapeutic alternatives in the management of the inflammatory crisis of this disease. The induction of tolerance to NSAIDs initiated by the authors has had clear clinical success. The basic biological reasons for this tolerance were evaluated in this study. A group of 11 sickle cell patients aged 12 to 39 years in whom post-NSAID respiratory manifestations disappeared for at least 6 months following a short tolerance induction protocol with ibuprofen, was assayed by ELISA for TNFα, INFg (Th1 cytokines), IL-4 (Th2 cytokine), IL-10, TGF-β (immunosuppressive cytokines) and total IgE, before induction or pre-induction (D-1) and at day one (D1), D2- 3, one month (M1), and M6 after induction. A repolarization of the Th1/Th2 balance was noted during the post induction period. The high concentration of IL-4 observed at D-1 gradually decreased in favor of the cytokines TNFα, INFg. The decrease in cytokine IL-4 with the level of total IgE was accompanied by the increase of IL-10 and TGF-β demonstrating the regulatory role of these cytokines in the control of allergic diseases. In conclusion, the induction of immuno-tolerance to NSAIDs through a short protocol is well supported by immune regulation. The medium-term effects are real, unlike the results of allergen desensitization or specific immunotherapy. However, this protocol could be used in certain circumstances such as in the case of intolerance to trimethoprim-sulfamethoxazole, used as the treatment of choice for the prevention of opportunistic diseases in people living with human immunodeficiency virus.
Screening for SARS-CoV-2 IgM and IgG antibodies among healthcare workers: A single-center study in Egypt
Authors:   Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Mohammad Mai
Published: October 2023

Coronavirus disease 2019 (COVID-19) pandemic has become a global public health disaster, spreading throughout the world. In order to accurately determine the extent of the pandemic, it is important to accurately identify the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among healthcare workers (HCWs). This study intended to determine the prevalence of SARS-CoV-2 infection among HCWs and examine its correlation with the demographic characteristics of the study participants prior to the implementation of the vaccination campaign. In this cross-sectional study included 431 HCWs from Suez Canal University Hospital in Ismailia, Egypt. Their sera were screened for SARS-CoV-2 antibodies using a one-step novel coronavirus (COVID-19) IgM/IgG antibody test from Artron, Canada. Positive cases were then confirmed using nasal swab real-time reverse transcriptase PCR from Viasure, Spain. Of the 431 study participants, 254 (58.9%) were males and 177 (41.1%) females. The majority of participants, 262 (60.8%), were younger than 30 years old, 150 (34.8%) between 30 and 40 years old, and only 19 (4.4%) older than 40 years old. Out of the total samples, 26 (6%) tested positive for SARS-CoV-2 IgM, while 19 (4.4%) tested positive for both IgM and IgG. The majority of the samples, 386 (89.6%), tested negative for both IgG and IgM. There was no association between the prevalence of SARS-CoV-2 and either sex or age of study participants. In conclusion, during the study period, the prevalence of SARS-CoV-2 infection among healthcare workers at Suez Canal University Hospital in Egypt was relatively low. Additionally, there was no significant correlation observed between the prevalence of positive cases and either age or sex.
Calcitonin gene-related peptide and its correlation with prognosis in severe pneumonia among children below 6 years at PICU of Al Zahraa university hospital
Authors:   Department of Pediatrics, Ministry of Health, Cairo, Egypt., Saad Sara
Published: October 2023

Pneumonia is known to be the biggest cause of death in children younger than five years old. In pulmonary diseases such as pulmonary arterial hypertension, asthma, acute lung injury, and pulmonary fibrosis, calcitonin gene related peptide (CGRP) has been linked to the regulation of inflammation, proliferation, and fibrosis. However, its ability to foretell the emergence of severe pneumonia is questionable. We aimed to determine whether blood levels of CGRP correlate with the outcome of critically ill children. This case-control study included 45 children with severe pneumonia admitted to the pediatric intensive care unit and 45 children with matched age and sex as controls. We investigated the serum level of CGRP as well as routine laboratory investigations of both groups. The CGRP level was lower in the patient group with median of 77 ng/L ranged from 55 to 183 as compared to control group with median of 230 ng/L ranged from 133 to 664 (p≤0.001). Also, CGRP level was significantly higher in the survived group with median of 96.1 ng/L ranged from 55 to 183 than the non-survived group with median of 63.4 ng/L ranged from 55.5 to 120.9 (p=0.022). In conclusion, we found that serum level of CGRP was extremely low in critical and extremely critically ill patients, and thus can be used as a predictor of mortality in children with severe pneumonia.
Mitochondrial DNA Copy Number as a Biomarker of Multiple Sclerosis
Authors:   Department of Clinical Pathology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Sedky Rana
Published: October 2023

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). In its early stages, it results in inflammation, demyelination, and axonal loss. Egypt has the highest rates in the Middle East region. The pathogenicity of MS involves mitochondrial function. Damage to mitochondrial DNA (mtDNA) can produce variation in the copy number (CN) and decline in mitochondrial function. Our goal was to determine the potential of mtDNA-CN as a biomarker of MS and the progression of the disease. The study included 25 patients with relapsing remitting MS (RRMS) and 25 age and sex matched apparently healthy control. Two peripheral blood samples were collected from each patient, one during the remission phase and the other during the phase of relapse. A quantitative real-time polymerase chain reaction (qPCR) was performed to assess CN of mitochondrial DNA. There was a statistically significant decline in the number of mtDNA copies during the remission phase as compared to controls (p<0.01), yet no difference was seen between mtDNA-CN in relapsing subjects versus controls. Moreover, the copy number of mtDNA during the relapse phase was significantly higher than the remission phase suggesting the ability of mtDNA to differentiate between remission and relapse phases (p<0.05). Our study observed that mtDNA-CN at a cut off (0.75), can differentiate between RRMS patients in the remission phase and controls with a sensitivity of 56%, specificity 84%, positive predictive value (PPV) 65.6% and negative predictive value (NPV) 77.8%, and at a cut off (1), mtDNA-CN can differentiate between remission and relapse MS patients with a sensitivity 72%, specificity 56%, PPV 62.1% and NPV 66.7%. In conclusion, mtDNA-CN can be proposed as a biomarker of MS.
Importance and Need of Medical Entomology and Medical Entomologist in Public Health
Authors:   International Journal of Medical Sciences and Nursing Research, Sureshbabu Jayanthi
Published: October 2023

Article Type: Editorial Importance and Need of Medical Entomology and Medical Entomologist in Public Health Year: 2023; Volume: 3; Issue: 3; Page No: 1 – 2 Author: Jayanthi Sureshbabu Affiliation: Editor-In-Chief, International Journal of Medical Sciences and Nursing Research, Coimbatore, Tamil Nadu, India and Former Lecturer in Medical Entomology, Department of Community Medicine, Pondicherry Institute of Medical Sciences, Kalapet, Pondicherry, India. Email ID: Editor-in-chief@ijmsnr.com How to cite this article: Sureshbabu J. Importance and Need of Medical Entomology and Medical Entomologist in Public Health. Int J Med Sci and Nurs Res 2023;3(3):1–2. Article Summary: Submitted: 20-July-2023; Revised: 18-August-2023; Accepted: 05-September-2023; Published: 30-September-2023
Head Start Teachers’ Views on the Family-Teacher Relationship: A Research-to-Practice Summary
Authors: Hooper Alison , Gaviria-Loaiza Juana
Published: October 2023

This study looked at Head Start teachers’ relationships with families. The purpose of the research was to document home-school relationships from the perspective of teachers and to understand the teacher characteristics that may predict how teachers perceive their relationships with families. The study used a national sample of Head Start teachers and a questionnaire called the Family Provider/Teacher Relationship Quality measure. Results suggest that teachers’ job satisfaction, caregiving beliefs, and depressive symptoms all predicted how they viewed relationships with families. These results point to the importance of continuing to support teachers’ psychological wellbeing and their developmentally appropriate beliefs, as these may promote positive relationships with families.
The Improvement of User Experience of Elderly in Hubei Province, China
Authors: Zhang Qian , Majid Ahmad Zuhairi Abdul
Published: October 2023

In China, few studies have been conducted specifically on the quality of life of elderly hospice patients. 2020, when the coronavirus outbreak occurred in Wuhan, Hubei Province. The researcher has personally experienced the closure of Wuhan and the desperation of the elderly to live because of mobility problems and chronic diseases. The importance of mobile health care for the elderly was deeply felt.
Research Purpose: Propose design solutions to optimize the hospice care mobile application by co-creating the discovery design process. To make the mobile application for hospice services more responsive.
Research Method: The researcher selected 20 respondents aged 60 and above to participate in face-to-face interviews. The real needs of the respondents were recorded and organized through semi-structured interviews, observation and interaction. MAXQDA software was used to do qualitative analysis. The preferred design of the user interface and user experience of the hospice app for the New Older was determined.
Main Results: By co-design the discovery design process, user participation in the co-design of the hospice app was found to help improve the sense of user service experience for Chinese elderly using a hospice-based mobile application.
Rijksinkoopvoorwaarden 2018 toe aan een update?
Authors: Bijloo M.W.
Published: October 2023

Rijksinkoopvoorwaarden 2018 toe aan een update?

Sinds jaar en dag maakt de overheid gebruik van specifieke algemene inkoopvoorwaarden voor de inkoop van roerende zaken bij derden, de Algemene Rijksinkoopvoorwaarden (ook wel afgekort tot ARIV). De meest recente versie is die welke gepubliceerd is in 2018 (ARIV 2018). In deze bijdrage wordt een aantal aspecten van de Rijksinkoopvoorwaarden 2018 onder de loep genomen vanuit het perspectief van de leverancier.
Necesidades formativas y comunicativas de profesionales de Atención Primaria de salud en el duelo perinatal (oral)
Authors: Martínez Satorres Alba , Escalé Besa Anna , Escribano Sanz Ana , Wagner Carolina , Díez García Lorena ,   Grup SEXIT Educació per una Sexualitat Sana i Positiva
Published: October 2023

OBJETIVOS
El abordaje del duelo perinatal (DPN) sigue siendo un tabú en nuestra sociedad y genera malestar e inseguridad entre el personal médico y de enfermería de la Atención Primaria (AP), quienes no están preparados para enfrentarlo.

La AP tiene un papel clave en su enfoque, pero se requiere una mayor formación de profesionales en DPN. Conocer las experiencias, opiniones y necesidades formativas del personal médico y de enfermería es fundamental para potenciar las intervenciones formativas.

Hipótesis: el DPN es un tema tabú e incómodo entre los profesionales de AP, que tienen poco conocimiento y pocas habilidades comunicativas para poder abordarlo correctamente.

Objetivos: detectar las necesidades de formación y comunicación en DPN entre profesionales de AP.

MATERIAL Y MÉTODOS
Estudio observacional transversal de tipo encuesta online, dirigido a profesionales de AP, durante los meses de marzo-mayo de 2022. Se analizan las siguientes variables: variables demográficas, conocimiento sobre factores de riesgo de pérdidas gestacionales, características y abordaje del DPN, comunidad, recursos y necesidades formativas percibidas.

Medidas principales. Encuesta autocompletada y anónima.

RESULTADOS
Se analizaron los resultados de 525 profesionales (250 profesionales de medicina, 119 profesionales de enfermería). 447 eran mujeres. El 91,6% de las personas encuestadas no había recibido ninguna formación. Del personal encuestado, el 85,2% respondió que como profesional de AP no tenía suficiente formación en DPN, y el 80,9%, que tenía interés (148/488) o mucho interés (247/488) en recibirla. El 54,8% prefirió la formación presencial; el 42%, la formación online, y el 3%, mixta.

CONCLUSIONES
Se detecta un bajo nivel de formación en el abordaje del DPN y un alto nivel de interés por la formación en este tema.

Es necesaria una formación continua de interés y calidad sobre el DPN y habilidades comunicativas para poder abordar correctamente desde la práctica clínica un tema aún tabú y difícil de tratar en AP.
Efectos beneficiosos de un programa de intervención artística sobre el estado emocional y las competencias transversales en el personal biosanitario: un ensayo controlado y aleatorizado
Authors: López Aragón Carlos Eloy
Published: October 2023

El presente trabajo de investigación tiene como objetivo describir el impacto de una intervención artística y un programa de intervención motora, basado en la música y la danza, sobre el estado emocional y las competencias transversales de profesionales de la sanidad.

La danza, como medio de expresión corporal, es una disciplina que, aparte de ser expresión artística y actividad física, es un lenguaje universal y ancestral que permite brindar un espacio seguro para sentir, compartir, expresar y comunicar vivencias desde el lenguaje no verbal1.

Tanto los recursos musicales como la danza son actividades complejas que comprenden integración motora y multisensorial (auditiva, visual y somatosensorial) de una forma única, abriendo canales de comunicación corporal a través de gestos y posturas que pueden favorecer el autoconocimiento, la autorregulación emocional, la empatía, las relaciones interpersonales, y de forma general, la mejora del bienestar subjetivo, las habilidades comunicativas y la salud de los profesionales sanitarios, a quienes va dirigido este estudio. Igualmente, presenciar artes escénicas genera una actividad cortical generalizada que involucra áreas del cerebro relacionadas con la atención, la semántica, el procesamiento, la memoria, la función motora y el procesamiento emocional2.

Desde los inicios de la humanidad, la danza y la música siempre han estado presentes como expresión y naturaleza del movimiento que el ser humano posee como propiedad y como sistema de comunicación humana. El propósito de este estudio es ofrecer herramientas de autocuidado y de afrontamiento del estrés desarrollando competencias emocionales en este grupo de población, así como favorecer el incremento de competencias transversales personales y sociales. Por ello, consideramos que es relevante seguir avanzando en una línea de investigación centrada en el ámbito de la salud que muestra los beneficios del movimiento corporal y la música en el estado emocional de los participantes objeto de este proyecto.
Proyecto estudio piloto antes-después y cualitativo de un nuevo modelo de consulta de Atención Primaria denominado «Hacer lo de hoy, hoy» (oral)
Authors: Arredondo Parages Marta , Jin Kim Jung Eun , Salazar García Patricia , Ramos Sánchez Paula , Castañón Manzano Alba
Published: October 2023

OBJETIVOS
Analizar un modelo de atención de consulta denominado «Hacer el trabajo de hoy, hoy» en un centro de salud de Atención Primaria (estudio piloto), mediante la comparación de los indicadores asistenciales antes y después de iniciar este proyecto. Conocer la satisfacción de profesionales y pacientes.

MATERIAL Y MÉTODOS
Estudio mixto: estudio piloto antes-después y cualitativo para conocer la satisfacción de profesionales y pacientes.

Ámbito del estudio: centro de salud de Atención Primaria.

Para el estudio antes-después se contará con todo el personal del centro de salud (profesionales de medicina, pediatría y enfermería, la matrona y el personal del servicio de admisión). Para el cualitativo, se empezará con 30 y se continuará hasta que se consiga saturación de la información.

En primer lugar, se diseñó el modelo de atención denominado «Hacer el trabajo de hoy, hoy» mediante grupos focales. Consiste en una redistribución horaria en las agendas y en cambiar la forma de asignación y de citación.

Tras el estudio de campo (6 meses), se realizarán entrevistas semiestructuradas de 1 hora, grupales y se grabarán en audio (seis grupos: medicina-pediatría, enfermería-matrona, personal de admisión y tres grupos de pacientes, uno de cada tipología). Las grabaciones se transcribirán el mismo día que se obtengan, tras lo cual serán destruidas. Se conservarán solo los textos. En los textos transcritos para analizar no figurarán datos personales, solo se asignará, por orden de intervención, un número correlativo del uno al número que corresponda.

Análisis estadístico: para analizar el modelo, se usarán las variables asistenciales (a fecha de 1 de enero de 2023) y se compararán con las previas (a fecha de 1 de enero de 2020), presentadas en los informes generados por el Servicio de Evaluación y Acreditación de la Dirección General de Asistencia Sanitaria del Departamento de Sanidad de Aragón (actividad asistencial, presión asistencial y demora), correspondientes al centro de salud seleccionado.

Se usará el programa estadístico Jamovi. Prueba estadística de Wilcoson.

La transcripción se hará mediante el programa de investigación cualitativa Atlas-Ti. Se realizará revisión por pares.

APLICABILIDAD DE LOS RESULTADOS ESPERADOS
Permitirá hacer un estudio preliminar de un nuevo modelo de Atención Primaria y conocer la posible mejora y en qué indicadores, así como si cuenta con la satisfacción de pacientes y personal del centro de salud.

ASPECTOS ÉTICO-LEGALES
Aceptado por el CEICA C.I. PI22/319 y se solicita consentimiento informado.

FINANCIACIÓN
Medios propios.

CEI
Aceptado por el CEICA C.I. PI22/319.
Atención centrada en la familia y consultas médicas triádicas: resultados de un estudio piloto (oral)
Authors: López Caballero Sandra , Respaldiza Berroeta Itxaso , Portugal Martínez Ander , Lynn Rogers Heather ,   Grupo ACP-Euskadi
Published: October 2023

OBJETIVOS
Los familiares en Atención Primaria (AP) están socioculturalmente aceptados en España, con un 20-40% de consultas triádicas. El objetivo del estudio fue empezar a conocer la percepción de los profesionales de la salud en AP y pacientes sobre la atención centrada en la familia (ACF) y la implicación de familiares en las consultas.

MATERIAL Y MÉTODOS
Estudio observacional transversal con personal de medicina, pediatría, enfermería, matronas y auxiliares de enfermería, así como con pacientes acompañados, en cinco centros de salud de Euskadi. Se incluyeron 94 profesionales de la salud y 32 pacientes que acudieron a la consulta con un acompañante, sin abandonos. Los/las profesionales completaron una versión modificada del Family Nurse Caring Belief Scale con tres subescalas. Los/las pacientes respondieron a cuatro preguntas tipo Likert de 1 a 5. Los datos se analizaron con test no-paramétricos. La principal limitación fue el número de visitas con acompañante. El estudio recibió la aprobación del comité de ética (CEIC PI2021204).

RESULTADOS
De 94 profesionales, el 44,6% fueron médicos/médicas con una media de edad de 45,3 años. El 87,2% fueron mujeres con una media de 13,9 años en AP y 6,1 años en su puesto actual. La puntuación total, las subescalas de la ACF y el rol de la familia fueron negativamente asociados con años en AP (p > 0,05). Respecto a los 32 pacientes, la media de edad fue de 69,9 años, siendo el 62,5% mujeres. El 78,1% fueron jubilados con 1,9 enfermedades crónicas y 5,7 consultas en AP de media el último año. Los acompañantes más habituales fueron hijos (n = 18) y cónyuges (n = 8). El 47% calificó la ACF con puntuación máxima y la media total fue 16,9 (7-20; desviación estándar [DE]: 3,6; mediana: 18,3).

CONCLUSIONES
Se pretende iniciar una línea de investigación, con seguimientos de consultas triádicas y comprobaciones de registros, para continuar el estudio de ACF.
A aplicabilidade da lei Nº 11.645 de 2008 na construção do projeto político pedagógico e do currículo escolar em Palmeira dos Índios-Alagoas
Authors: Lima Gleicielle Tenório de Holanda , Bezerra Ricardo José Lima
Published: October 2023

A presente pesquisa propõe apresentar como se desenvolveu a aplicabilidade da Lei nº 11. 645/2008 no âmbito de uma política curricular para o ensino básico, através do Projeto Político Pedagógico (PPP) como instrumento de trabalho para construção de uma escola democrática e participativa em Palmeira dos Índios-AL.  Os objetivos centrais deste artigo foram identificar as ações em torno da construção do PPP com ênfase no trabalho a lei 11.645/08; identificar de que forma tem sido pensado o currículo das escolas após 15 anos a vigência da lei; visitar a legislação vigente sobre a cultural no município visando reformulação para novos caminhos. A metodologia utilizada inclui abordagens da pesquisa qualitativa e quantitativa.
Entre o arcaico e o tecnológico: limites e desafios do uso da tecnologia na prática jurídica
Authors: Simioni Rafael Lazzarotto , Da Silva Marina Helena Vieira
Published: October 2023

Em um momento de crescimento exponencial dos mecanismos tecnológicos em sociedade, com a possibilidade de evidente visualização da revolução tecnológica que o mundo vive, tem-se, como consequência, a existência de reflexos que afetam, dentre outras disciplinas, também o direito. Assim, como uma consequência da revolução digital, observa-se uma tendência a um processo de simplificação dos conteúdos jurídicos, levando, muitas vezes, a textos e práticas rasas e carentes de fundamentação. O objetivo do presente artigo é enfrentar o problema da utilização tecnológica no direito de forma inadequada, sendo necessária a consolidação de teoria aliada à inteligência humana, de modo a relacionar o que é aprendido com o que pode ser executado na prática a partir do uso do digital, em uma verdadeira operacionalidade do sistema jurídico, não de forma apartada do tecnológico, mas sim em uma coexistência racional e equilibrada.
Racismo institucional e criminalização: uma discussão necessária
Authors: Barcelos Rafaela Gomes , Rodrigues Viviane Mozine
Published: October 2023

O presente trabalho traz uma modesta contribuição para o debate sobre o racismo institucional e seu viés com a Segurança Pública. Conceitua-se o racismo institucional e sua forma de manifestação na sociedade brasileira, colonial e contemporânea. O objetivo desse artigo é promover uma discussão sobre a criminalização da população negra no Brasil. Para isso, faz uma revisão de literatura e traz dados que corroboram a hipótese deste artigo em que a população negra é a que mais morre em decorrência de ações estatais na esfera da segurança. Espera-se com esse artigo acalorar a discussão acadêmica sobre a temática a fim de ver surgir mais artigos e discussões que contribuem para uma educação antirracista na sociedade.
The Potential of Budget Participation and Dalihan Natolu Leadership Style to Improve Community Welfare in the Toba Caldera Tourism Geography Area
Authors: Manurung Amran , Erlina  , Sirojuzilam  , Lubis Suwardi
Published: October 2023

Objective: This research analyzes the determinants of budgetary participation's effect on financial performance through Dalihan Natolu's leadership style in 4 districts in the Toba Caldera region and conducts a descriptive economic analysis of social and economic indicators in 7 districts post-Regional Autonomy and Fiscal Decentralization. Analyze village category development using the village development index (IDM) in 7 Toba Caldera districts. Estimating economic development parameters in 7 Toba Caldera districts in North Sumatra.
 
Method:  This study uses a quantitative method with descriptive analysis. Descriptive statistical analysis in this study was carried out using frequency distribution analysis and inferential statistical analysis including: evaluation of the assumptions of the structure equation model (SEM), SEM analysis, model fit test and hypothesis testing. The data analysis technique in this study uses Partial Least Square (PLS). PLS is a Structural Equation Modeling (SEM) equation model with an approach based on variance or component-based structural equation modeling. This research was conducted in 4 (four) administrative districts located around the Lake Toba Tourism Area which in their kinship life absolutely adhere to the local wisdom of Dalihan Natolu, namely Toba Regency, Samosir Regency, North Tapanuli Regency, Humbang Hasundutan Regency.
 
Conclusion : This quantitative study's findings Budget Participation Factor also affects Financial Performance moderated by Dahlian Natolu's Leadership Style, as shown by t statistics > t table (3,961 > 2,032). To strengthen this analysis, you can also use the P Value, with the condition p < 0.05, which shows 0.000 < 0.05. In 2019, the Human Development Index in 7 Toba Caldera Region Regencies measured Life Expectancy (UHH), Average Length of Schooling (RLS), and Expenditure Per Capita. In 2019–2020, the Toba Caldera Region's Gross Regional Domestic Product (GRDP) is stable and led by Agriculture, Forestry & Fisheries, Wholesale and Retail Trade, and Industrial Management. Karo Regency has the highest HDI and Humbang Ha Anglean the lowest. The comparative IPD for that year increased in 7 Toba Caldera Region Regencies from 2014 to 2018. Toba Caldera districts' Human Development Index (IPM) increases somewhat with GRDP per capita.
OBTENÇÃO DE BIODIESEL METÍLICO A PARTIR DA TRANSESTERIFICAÇÃO IN SITU DAS SEMENTES DE CUMBARU (Dipteryx alata Voguel)
Authors: Cunha Isabel Matos Fraga , De Brito Keyte Lorrany França , Silva Marli de Amorim
Published: October 2023

Dentre tantas matérias primas alternativas para a produção de biodiesel, o cerrado mato-grossense, especificamente no município de Cáceres-MT, conta com a presença marcante em sua vegetação, da espécie Dipteryx alata Voguel, popularmente conhecida como Cumbaru, rica em teor oleaginoso. No Brasil, a metodologia mais utilizada para a produção de biodiesel é a reação de transesterificação alcalina convencional, que requer um processo prévio de extração e tratamento de óleo. Esse processo além de ser caro e demandar muito tempo, requer a utilização de solventes apolares como o hexano. O pressente estudo tem como objetivo a obtenção de biodiesel metílico a partir da transesterificação in situ das sementes de Cumbaru (Dipteryx alata Voguel) a fim de diminuir o tempo e custos de produção e eliminar a utilização de solventes no processo. Foram obtidos o biodiesel in situ e para efeito de comparação, foi obtido também o biodiesel de cumbaru de maneira tradicional. Foi possível observar nesse estudo que o biodiesel obtido a partir da transesterificação in situ das sementes de cumbaru (BCIN) apresentou-se dentro dos padrões da ANP, já o biodiesel de cumbaru obtido pela metodologia tradicional, forneceu um produto fora dos padrões e que não pode ser comercializado. O processo de transesterificação in situ mostrou-se altamente promissor para as sementes de cumbaru.
OS ESTEREÓTIPOS SOBRE O GÊNERO FEMININO COMO INFLUÊNCIA NA DISPUTA DE GUARDA EM CASOS DE ALEGAÇÃO DE ALIENAÇÃO PARENTAL
Authors: Souza Jhuly Jamaire Vitor , Arouca Milene Motta , Felipe Glenda de Almeida , Bastos Markelle Ribeiro , Da Rocha Wollace Scantbelruy
Published: October 2023

O presente estudo apresenta a influência dos estereótipos do gênero feminino na dinâmica das alegações de alienação parental na justiça brasileira.  A Alienação Parental é um tema complexo a ser discutido, no entanto, associado à discussão do estereótipo de gênero nos leva a uma análise mais direcionada, quanto ao estereótipo, historicamente enraizado na sociedade, podem afetar a forma como os casos de alienação parental são percebidos e tratados no sistema jurídico. O principal objetivo do estudo é compreender a partir da psicologia como os estereótipos sobre o gênero feminino podem influenciar na dinâmica de alegação da alienação parental nos casos de disputa de guarda na justiça brasileira. Pretende-se apresentar o fenômeno da alienação parental no contexto da justiça brasileira, assim como, investigar a construção dos estereótipos de gênero e seus desdobramentos na história e nas relações parentais, como também identificar a percepção da psicologia diante dos estereótipos de gênero nos processos de alienação parental no Brasil. A metodologia que foi aderida para a realização deste estudo é a revisão bibliográfica de caráter exploratório, que proporciona a análise de artigos científicos, leis, livros que discorrem as diferentes perspectivas sobre Alienação Parental e a construção do Estereótipo ao longo da história. Dessa forma, a pesquisa leva aos profissionais da psicologia, do judiciário e a sociedade, a reflexões sobre o referido tema.
Effect of nitrogen levels and weed management on weed flora and yield of direct-seeded rice (Oryza sativa) in southern part of Punjab
Authors: SINGH VICKY , SEPAT SEEMA , SINGH JASBIR , GAUTAM ANAND , AULAKH G S
Published: October 2023

An experiment was conducted at Krishi Vigyan Kendra, Ferozepur, Punjab during rainy (kharif) seasons of 2018 and 2019 to study the effects of nitrogen levels and weed management in direct-seeded rice (Oryza sativa L.) (DSR). The results indicated that pendimethalin + bispyribac (W1) (5.25 and 2.95 m2) and oxadiargyl + bispyribac (W2) (6.05 and 3.95 m2) application reduced the density of narrow-leaved weeds (NLW) and broad-leaf weeds (BLW) followed by oxadiargyl + fenoxaprop (W3) (7.0 and 4.55 m2) during both the years. Application of W1 decreased the total weed biomass by 84–98.2%, respectively compared to weedy check (W5) (80.1 and 94.8 g/m2) in both years. Treatment W1 and W2 recorded at par values of grain and straw yield followed by W3. An increase (48.6–72.0%) in grain yield was registered with weed practices compared to weedy check in DSR. W1 and W2 significantly recorded higher N uptake in grain (61.45 and 60.85 kg/ha) and total (100.8 and 99.45 kg/ha) followed by W3 (53.85 and 90.35 kg/ha, respectively). The high infestation of BLW with W3 resulted in the lowest weed control efficiency (WCE) (46.2–53.9%) among the weed control practices. N at 120 and 150 kg/ha recorded the low density and biomass of NLW and BLW. Application of 120 and 150 kg N/ha enhanced the grain yield (4.89 and 5.25 t/ha) and net returns (55.1 and 60.5 × 103 ₹/ha) in both years. No N application recorded lowest N uptake in grain (87.71 kg/ha) and total (80.26 kg/ha) compared to 150 kg N/ha in both years. N levels at 120 and 150 kg/ha recorded higher values of water control efficiency (WCE). Based on the findings, it may be concluded that pendimethalin + bispyribac and oxadiargyl + bispyribac with N 120 kg/ha application can reduce weed flora diversity with higher grain yield of direct-seeded rice in Punjab.
Crop establishment and nutrient management for production sustainability in rice (Oryza sativa)-wheat (Triticum aestivum) system in eastern India
Authors: SAHU RAGHUBAR , KUMAR DHARMENDRA , SOHANE R K , KUMAR RAKESH , KUMAR ANJANI , MANDAL SANJAY KUMAR , PRASAD MUNESHWAR , SAHU JUBULI
Published: October 2023

In eastern Indo-Gangetic Plains (EIGP), conventional rice (Oryza sativa L.)-wheat (Triticum aestivum L.) system has led to a decline in total factor productivity, input-use efficiency, and profitability. A three-year (2020–2022) field experiment was conducted at the farmers’ fields in Merha village of Katoriya, Banka, Bihar on a sandy clay loam soil to evaluate the impact of crop establishment and nutrient management on production sustainability in rice-wheat cropping system. Experiments were conducted in a split-plot design and replicated thrice. The main-plot treatment had crop establishment methods, viz. (i) Broadcasting: paddy seed broadcasted manually; (ii) Dry seeding: seed drilled on moist soil; (iii) Drum-seeding: dry-seed planted using drum seeder on moist soil and; (iv) Wet-seeding: sprouted seeds broadcasted on puddle soil with variety Sabour Ardhjal in rainy (kharif) season and 4-wheat crop establishment method, viz. (i) Broadcasting in CT; (ii) Furrow irrigated raised-bed method; (iii) ZT-drill and; (iv) Seed-cum-ferti-drill machine for wheat variety HD 2967 in winter (rabi) season. The sub-plots were allotted four nutrient management treatments, viz. (i) Farmers’ practice (130:40:10 kg NPK/ha); (ii) 100% RDF (120: 60:40 kg NPK/ha); (iii) Soil- test-based nutrient management (100% chemical fertilizer-125:75:40 kg NPK/ha) and; (iv) Soil-test based nutrient management (75% chemical fertilizer-94:56:30 kg NPK/ha+25% FYM-6.2 t/ha) in wheat, and (i) Farmers practice (140:30:10 kg NPK/ha); (ii) 100% RDF (120:60:40 kg NPK/ha); (iii) Soil-test based nutrient management (100% chemical fertilizer-150:75:40 kg NPK/ha); (iv) Soil-test based nutrient management (75% chemical fertilizer-115:56:30 kg NPK/ha+25% FYM-7 t/ha) in wheat. Our results revealed that overall system productivity and profitability were higher by 44 and 155.5% in wet seeding paddy-ZT drill wheat system in comparison to broadcasting methods of rice and wheat. System productivity was significantly higher by 28.8% in soil-test based nutrient management production system as compared to the farmers' practices. Thus, to achieve better system productivity and profitability, crops may be grown with wet seeding paddy-ZT drill wheat with soil-test based nutrient management practices under eastern Indo-Gangetic Plains of eastern India.
PCSK9 in extrahepatic tissues: What can we expect from its inhibition?
Authors: Pirillo Angela , Tokgözoğlu Lale , Catapano Alberico L.
Published: October 2023

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme that belongs to the serine protease family and plays a key role in regulating low-density lipoprotein cholesterol (LDL-C) levels in the blood. PCSK9 binds to the LDL receptor (LDLR), targeting it for degradation, resulting in an increase in circulating LDL-C levels. Loss-of-function mutations in the PCSK9 gene are associated with lower LDL-C levels and lower cardiovascular risk; in contrast, gain-of-function mutations are a cause of familial hypercholesterolaemia. The identification of PCSK9 as a pharmacological target led to the development of inhibitors for the treatment of hypercholesterolaemia. To date, the monoclonal antibodies evolocumab and alirocumab (which target plasma PCSK9) and the small-interfering RNA inclisiran (which targets hepatic PCSK9 mRNA) have been approved for the treatment of hypercholesterolaemia. Although hepatic PCSK9 plays a central role in regulating plasma LDL-C levels, this protein is also expressed in other tissues, including the brain, pancreas, heart, kidney, intestine and adipose tissue. In extrahepatic tissues, the functions of PCSK9 are both dependent and independent of LDLR and not necessarily harmful. For this reason, it is essential to uncover any potentially harmful effects of therapies that inhibit PCSK9, beyond their known LDL-C-lowering and CV risk-reducing effects.
Strategic Procurement Initiatives and Logistics Performance in Nigeria
Authors: Dr Effa Godwin Assam , Dr Ovharhe Orugba Harry , Prof Ezirim Aloy Chinnedu , Prof. Igwe Sunny
Published: October 2023

This study investigated the strategic procurement initiatives and logistics performance in Nigeria. The study adopted analytical cross sectional design and correlation design. Randomized quota of business owners from ten selected logistics on basis of accidental sampling technique and quota sampling method was utilized for the study. A total population of 400 and sample size of 200 was determined using Slovin's Formula at 0.05 level of significance. The 200 copies of questionnaire were administered, only 196 was deem fit after processing, retriever, coding and cleansing. The Parallel reliability was used to determine the consistency of the instrument that results to 95.50 (0.955). Two research questions and two hypotheses were raised which was tested with parametric measurement using Pearson Product Moment Correlation because of its monotonic functionvia SPSS 25 version. From the findings, procurement sustainability initiatives concept strongly correlates with the logistic performance proxies. Hence, procurement initiatives and e-procurement significantly facilitates the effectiveness and efficiency of logistic performance. Hence, it was revealed that the alternate hypotheses were accepted. Based on the findings and conclusion, this study contributes to the knowledge that e-procurement facilitate logistics performance. It could be recommended that management of logistics firms should adopt strategic initiatives to enhance logistics performance in the area of cost savings; adopting and implementing initiatives such as outscoring, groups purchasing organization, just-in-time and suppliers management relationship.
An Appraisal of Public Relations Strategies of Select Multinational Companies in Rivers State
Authors: Ebere Confidence , Okon Prof. Godwin Bassey
Published: October 2023

This study was informed by the need to appraise the public relations strategies of select multinational companies in Rivers State. The study is made up of managers of both Pabod Breweries and Daewoo on one stream while the residents of the host communities made the second stream. More so, a sample size of 398 was drawn using Taro Yamane formula, and purposive sampling respectively. The survey was adopted for the study. The multistage sampling technique was to draw respondents from the headquarters of two companies and the various host communities. Moreover, face and content validity were done by experts in the field while the Crouchback Alpha coefficient was used to test for instrument reliability. The questionnaires were the instrument for data collection. Furthermore, data were analysed using tables, percentages and weighted means score on a four point Likert scale. To this end, results showed that the PR practices of Pabod Breweries (108 or 60.7%) are more effective than Daewoo Nigeria Limited (84 or 44%). Findings also reveal that both Pabod Breweries and Daewoo Nigeria Limited maintain their relationship with their host communities. Sequel to this, the study among other position concluded that the dynamics of host-corporate relations has informed the need for organisation to revisit their public relations policies. The study therefore, recommends that multinational companies should revisit their public relations policies with a view of strategically identify and carryout public relations practices that are not only stakeholder-centered but will also help in actualizing organisational goals. This could be better achieved with greater stakeholder engagement research.
Cash Management and Financial Performance of Quoted Non- Financial Firms in Nigeria: A Dynamic Robust Least Squares Regression Approach
Authors: Lawrence U. Egbadju
Published: October 2023

This study investigates the impact which cash management and the financial performance of selected firms in Nigeria. The period which the study covers is from 2005 to 2020 of 76 non- financial firms quoted on the floor of the Nigerian Exchange Group the information about them are extracted from their financial statements. The results of the dynamic robust least squares indicated that while cash and cash equivalence (CCE), average collection period (ACP), days sales outstanding (DSO), days inventory outstanding (DIO) and sales growth (GSALES) are positively significant with economic value added (EVA); cash conversion cycle (CCC), average payment period (APP), days payment outstanding (DPO), quick ratio (QR), short term debt (STD) and capital expenditures (CAPEX) are negatively significant with it. The study concludes with some recommendations.
Health Communication and Port Harcourt Residents’ Perception of the Coverage of Diabetes Mellitus in Select Newspapers
Authors: Ikechi Chibitam Kem , Ihejrika Prof W.C. , Mbazie S.C.
Published: October 2023

This work analysed health communication and Port Harcourt residents’ perception of newspaper coverage of diabetes. The objectives were to: examine the level of exposure of Port Harcourt residents to the diabetes health messages; examine the perception of Port Harcourt residents on newspaper coverage of diabetes. The work was anchored on the Perception theory and development media theory. The population in Port Harcourt and Obio/Akpor is projected from 2006 census to 2022 using the 2.5 projection rate. Therefore, the population for this study shall be ( 6,498,395 ) six million, four hundred and ninety-eight thousand three hundred and ninety-five (UNDP). The sample size of 400 was drawn using the Krejice and Morgan sample size table. The purposive sampling technique was used to select residents of Port Harcourt who are newspaper readers. Findings revealed that residents’ of Port Harcourt get diabetes messages from newspapers and other channels like family and friends, television and most importantly from broadcast medium The study also showed that residents’ of Port Harcourt Metropolis have a positive view on the newspaper been adequate for the coverage of health issues which also includes diabetes mellitus. The study recommended that Nigerian newspapers should publish editorials, features and photographs on diabetes prevention and management and other health related issues, because it will help increase the awareness of readers and help them appreciate prevention and management of diabetes intervention and other health intervention programmes available to them.