bluuebunny/crossref_metadata_2025 huggingface dataset:
Has the United States Reached a Plateau in Overdoses Caused by Synthetic Opioids After the Onset of the COVID-19 Pandemic? Examination of Centers for Disease Control and Prevention Data to November 2021
Authors: Brown Kate G. , Chen Carina Y. , Dong Deanna , Lake Kimberly J. , Butelman Eduardo R.
Published: July 2022

Background

Overdoses caused by synthetic mu-opioid receptor (MOR) agonists such as fentanyl are causing increasing mortality in the United States. The COVID-19 pandemic continues to have complex effects on public health, including opioid use disorders (OUD). It is unclear whether recent increases in mortality caused by synthetic opioids have reached a plateau (i.e., a stable period), after the onset of the COVID-19 pandemic.

Method

This study examined provisional overdose mortality data from the Centers for Disease Control and Prevention, for synthetic opioids excluding methadone (code T40.4; monthly data available from 39 States, plus New York City and Washington DC), for June 2019–November 2021. Data were first examined as crude mortality rates. The presence of a maximum plateau was analyzed for the last 4 months of available data. For authorities in which a plateau in mortality was detected, sigmoidal Boltzmann equations were used to model parameters of this phenomenon (e.g., level of the plateau).

Results

At the end of the study period, all but one authority (New Hampshire) reported increases in mortality rates for synthetic opioids, compared to the baseline month of June 2019 (range: 111–745% of baseline). A plateau was observed over the last 4 months of the study period (Aug 2021–Nov 2021) in 29 of the authorities. Ten other authorities had not reached a stable plateau at the end of the study period. For the authorities where a plateau was detected, a sigmoidal Boltzmann model revealed a fitted maximum of 262% rise in mortality over the study period, from the baseline month. The midpoint in the rise in mortality was fitted in September 2020. After separation of data into census regions, the highest plateau was observed in the West region, followed by South, Midwest, and Northeast (fitted plateau values were 409, 262, 204, and 149% of baseline, respectively).

Discussion

There were increases in overdose mortality due to synthetic opioids across most states, ranging considerably in magnitude. A plateau in overdose mortality was detected at the end of the study period in most of these authorities. The reasons for these plateaus should be explored, in order to develop optimized public health interventions.
The Utility of a Pediatric COVID-19 Online Forward Triage Tool in Switzerland
Authors: Michel Janet , Mettler Annette , Starvaggi Carl , Travaglini Nicola , Aebi Christoph , Keitel Kristina , Sauter Thomas C.
Published: July 2022

Background

To offset the burden on the health system, hospitals set up telehealth interventions, such as online forward triage tools (OFTT). The website www.coronabambini.ch was developed to specifically address the needs of children and their families in Switzerland and to facilitate the decision to test, isolate, attend school, or access the health care system.

Methods

Video interviews were held with key informants (n = 20) from a population of parents, teachers, guardians, as well as doctors who had used the child-specific COVID-19 OFTT and had consented to a further study. Convenience and quota sampling were done to include a variety of key informants. Interviews were recorded, transcribed verbatim, and analyzed for themes.

Results

Three main themes emerged: i) the usefulness of the OFTT to the users, ii) expectation management and importance of stakeholder involvement in OFTT development, and iii) OFTT limitations.

Conclusion

Our study highlights opportunities, limitations, and lessons to consider when developing a pediatric COVID-19 OFTT. The involvement of stakeholders, parents, teachers, and health care providers in the design, set up, implementation, and evaluation of telehealth interventions is critical as this can help with expectation management and enhance OFTT utility.
Organization of Medical Assistance in Poland for Ukrainian Citizens During the Russia-Ukraine War
Authors: Fatyga Edyta , Dzięgielewska-Gęsiak Sylwia , Muc-Wierzgoń Małgorzata
Published: July 2022

From 24 February 2022 to 29 March 2022, Poland has taken 2,377,000 refugees fleeing Russia's invasion of Ukraine. They are mostly women, children, and the elderly. In this article, we present all activities and types of medical resources provided and organized in Poland for refugees from the first days of the conflict. Information has been compiled from the data available on the Polish Ministry of Health, other governmental and non-governmental organizations, foundations, and medical societies.
Impact of the Pandemic on Selected Aspects of Health-Promoting Attitudes in 2020–2021: A Cross-Sectional Study
Authors: Kułak-Bejda Agnieszka , Bejda Grzegorz , Kułak Wojciech , Guzowski Andrzej , Fiłon Joanna , Łukaszuk Cecylia , Cybulski Mateusz , Waszkiewicz Napoleon , Krajewska-Kułak Elzbieta
Published: July 2022

Introduction

In the face of the COVID-19 pandemic, people began to change both their health-promoting and anti-health behaviors.

Aim of the Paper

To assess the impact of the pandemic on selected health-promoting attitudes.

Methods

The cross-sectional study was conducted from March 2020 to September 2021. We have used the author's survey questionnaire and the standardized Wellness Behaviors Inventory (WBI). The questionnaires were given to respondents in paper versions to fill it.

Results

The study group included 600 urban residents aged 32–73. Based on the opinions of the respondents, during the pandemic, the following activities increased the most: hand washing (93.3%), eating sweets and snacks (80%), and surfing the Internet (60%). An increase in drug/legal use was reported by 13.3%, with no indication of a decrease or no change in consumption of the above. The overall WBI index for all subjects before the pandemic was 81.3 ± 20.2 points, and the increase significantly (p < 0.001) during the pandemic was 87.7 ± 16.7 points. In addition, an increase in preferred eating habits was found (from 19.5 ± 6.4 to 21.1 ± 6.9 points; p < 0.001), preferred prophylactic behaviors (from 21.1 ± 6.0 to 22.7 ± 5.2 points; p < 0.001) and level of presented health practices during the pandemic (from 20.3 ± 5.1 to 24.7 ± 2.7 points; p < 0.001), and a decrease significantly (p < 0.001) in the degree of positive mental attitude (from 20.3 ± 5.4 points to 19.3 ± 4.9 points).

Conclusions

Respondents generally rated their own and their family's health as worse during the pandemic period, and this trend continued when broken down by gender, cohabitant, place of residence, and education. According to the largest group of respondents, the frequency of handwashing, eating sweets and snacks, surfing the Internet, and using drugs/legal highs increased the most during the pandemic. The overall WBI index for all respondents before and during the pandemic was slightly higher during the pandemic period. Monitoring health behavior during a pandemic is essential for prevention and health care institutions. Further studies are needed to assess the long-term impact of the pandemic on pro-and anti-health behavior of people.
Governance Quality, Public Health, Education, and Innovation: Study for Novel Implications
Authors: Wu Ning
Published: July 2022

Pandemic or worldwide disease is the greatest issue of all time that not only affects human health but also influences the economic, educational, and other activities of the countries, since malaria is among the leading health disease that disrupts the economic system of the country. Therefore, this study aimed to analyze whether educational expenditure and technological innovation influence malarial incidence in emerging economies. This study also examined the role of government effectiveness, government health expenditure, gross domestic growth, human capital, and research and development during the period 2000–2018. Employing panel data approaches, including the slope heterogeneity and cross-sectional dependence, the second-generation unit root test reveals the stationarity of all variables. The study also validated the existence of a long-run relationship between the variables. Based on the asymmetrical distribution properties, this study employed the quantile regression approach. The empirical results asserted that education and technological innovation significantly reduce malarial incidents in the panel economies. Also, government effectiveness, research and development, and human capital adversely affect incidences of malaria. In contrast, gross domestic product is the only factor found that increases malarial incidents during the selected period. Based on the empirical results, this study suggested policy measures that could benefit the governors, policymakers, and scholars.
Methemoglobinemia and Delayed Encephalopathy After 5-Bromo-2-Nitropyridine Poisoning: A Rare Case Report
Authors: Shi Longke , Yu Guangcai , Zhao Liwen , Wen Zixin , Li Yaqian , Kan Baotian , Jian Xiangdong
Published: July 2022

5-bromo-2-nitropyridine, an intermediate in the synthesis of pharmaceutical and pesticide products, is toxic to the human body. However, 5-bromo-2-nitropyridine poisoning has not been previously reported. Here, we report the case of a 40-year-old man who suffered skin and respiratory tract exposure to leaked 5-Bromo-2-nitropyridine at work. After exposure, the patient rapidly developed dizziness, fatigue, nausea, vomiting, chest distress, diffuse cyanosis, and coma. Methemoglobinemia, hemolytic anemia, rhabdomyolysis, and acute renal failure were observed after admission. He improved markedly after treatment, but delayed encephalopathy was confirmed 82 days after the exposure. This case highlights that 5-bromo-2-nitropyridine can be absorbed through the skin and respiratory tract, resulting in methemoglobinemia and delayed encephalopathy.
The Consistency Between the Chinese Essential Medicines List and Treatment Guidelines—Taking Oncology Medicines as an Example
Authors: Cheng Luyan , Li Caiyun , Zhang Xuefang , Chen Yongfa , Yan Jianzhou
Published: July 2022

The concepts of “essential medicine” and “national medicine policy” were first put forward for the first time at the World Health Assembly in 1975 in an effort to alleviate the problem of medicine unavailability in developing and poor countries. The essential medicine system in China has experienced three development stages since 1979, when the concept of essential medicines was first introduced, to actively respond to the call of the World Health Organization. Currently, the essential medicines list published in China is the national essential medicines list (2018 Edition). In this study, we examined the consistency between the essential medicines for treating seven cancers (liver cancer, breast cancer, esophageal cancer, lung cancer, colorectal cancer, gastric cancer, and leukemia) and the recommended medicines by cancer treatment guidelines to determine whether the essential medicines are of high quality for clinical needs. The results indicated that the degree of similarity between oncology medicines on the essential medicines list and oncology medicines recommended by guidelines was low, with the majority falling between 30 and 60%. Therefore, to improve the quality of essential medicines, it is necessary to further improve the matching degree. In addition, to further improve the consistency between the essential medicines list and treatment guidelines, the following suggestions are put forward in this paper: (1). Formulate universal treatment guidelines; (2). When selecting essential medicines, greater consideration should be given to those recommended in the guidelines; (3). The essential medicines list and treatment guidelines should be concurrently updated; (4). The cycle for updating the essential medicines list and treatment guidelines should be shortened.
Role of Actors in the Processes of Sustainable Development at Local Level—Experiences From the Czech Republic
Authors: Dlouhá Jana , Vávra Jan , Pospíšilová Marie , Dvořáková Líšková Zuzana
Published: July 2022

In this text we are interested in the preconditions for, and opportunities provided by sustainable development at local level in non-metropolitan areas, i. e., in rural areas and villages. These areas are generally seen as having an important role in achieving sustainability. The literature review highlights the general principles of endogenous development with an emphasis on local resources including human potential and social capital, and the Czech context. In practice, the empowerment and cooperation of regional actors is crucial for the sustainable transition of rural areas; an analysis of the local situation was thus conducted from the perspective of social capital. Research primarily questioned the role of local actors in different areas related to sustainable development, their relationships and involvement in sustainability processes, as well as deficiencies in social conditions creating barriers to sustainable development. The research methods selected to answer these questions reflected the context-specific, scientifically-overlooked character of the theme of this research where emerging phenomena were at the center of our interest. A survey conducted with representatives of the National Network of Local Action Groups (LAGs) mapped the situation in 50 (out of 180) LAGs in the Czech Republic (28 % of the total number). Data were analyzed quantitatively (single and multiple-choice questions), in combination with qualitative methods which were used to transform and aggregate responses into conceptual categories which were monitored for frequency (to observe majority opinion). The diversity of local actors, their relationships and roles in the sustainable development processes was thus illustrated. A snapshot of actors' current involvement in specific areas of sustainable development was compared with their potential involvement in these areas illustrating the importance of social capital which is not always recognized in relevant policy documents. The engagement of these diverse actors in sustainability transition processes is less evident: in most of the categories of change, the role of public administration prevails. According to the respondents, these changes that would ensure a sustainable future of the regions are often not taking place. While some of these findings may be specific to geographically-defined regional conditions and the Czech historical context, the research raised theoretically relevant questions concerning the role of social capital in sustainability processes.
Employing a Socio-Technical System Approach in Prospective Life Cycle Assessment: A Case of Large-Scale Swedish Sustainable Aviation Fuels
Authors: Lai Yat Yin , Karakaya Emrah , Björklund Anna
Published: July 2022

Ambitious fossil-free targets imposed on the aviation industry worldwide demand a large volumetric supply of sustainable aviation fuel (SAF) to meet. Sweden's commitment to a 30% volume SAF blending target by 2030 attracts interest in local production. However, the sustainability of local production is largely unknown. Addressing this gap, we aim to explore potential SAF technology pathways and assess their environmental performances in Sweden. To do so, we utilize a socio-technical system (STS) approach for pathways selection and prospective life cycle assessment (LCA) for environmental impact assessment. As a result, we identify two lignocellulosic-based and two electrofuel-based pathways and evaluate their global warming potential, mineral depletion potential, ionizing radiation, land use, freshwater ecotoxicity and human toxicity impact in comparison to jet fuel. Our findings show that the well-to-wake global warming potential (100 years) of 30% SAF is on average 20% lower than that of jet fuel, with non-carbon dioxide species emitted in flight being the major contributors, prompting the need for urgent research efforts to mitigate their potential impacts. Under the assumption that no burdens are allocated to waste material used as feedstock, lignocellulosic-based 100% SAF has a well-to-pump climate impact (100 years) ranging from 0.6 to 1.5 g CO2−eq/MJ compared to jet fuel's 10.5 g CO2−eq/MJ. In contrast, the well-to-pump climate impact (100 years) of electrofuel-based 100% SAF (ranging from 7.8 to 8.2 g CO2−eq/MJ) is only marginally lower than that of jet fuel, mainly attributed to emissions from steel and concrete produced for wind turbine manufacturing. In general, the use of electricity generated by wind power could shift the potential environmental burden associated with jet fuel from global warming to mineral depletion, land use, freshwater ecotoxicity and human toxicity. The STS approach underscores the need to prioritize changes in systems underpinning SAF production, in turn supporting policy and investment decision making.
Knee Movement Characteristics of Basketball Players in Landing Tasks Before Onset of Patellar Tendinopathy: A Prospective Study
Authors: Feng Ru , Best Thomas M. , Wang Lin , Gao Weiwei , Liu Hui , Yu Bing
Published: July 2022

Background

Patellar tendinopathy is one of the most common injuries for basketball players. Jumping and landing movement patterns are potential risk factors for patellar tendinopathy.

Hypothesis

Male college basketball players who developed patellar tendinopathy would demonstrate greater peak vertical ground reaction force and knee flexion angular velocity, and smaller knee flexion range of motion and knee flexion angles at initial contact compared to players who did not develop the injury when performing a stop-jump task within a year prior to the onset of the injury.

Study Design

Prospective study.

Methods

Freshmen college basketball male players (n = 181) were recruited for three consecutive years and followed to the end of the third year of the study. Three-dimensional kinematic and kinetic data during a stop-jump task were collected for all participants at the beginning of each school year. Peak vertical ground reaction force, knee flexion angle at initial foot contact with the ground, range of motion for knee flexion and maximal knee flexion angular velocity during the landing phases of the stop-jump task were collected and calculated. Development of patellar tendinopathy was monitored in follow-up. Independent t-tests and Cohen's d effect sizes (ES) were used to compare movement patterns between injury and no injury groups for each school year.

Results

A total of 60 knees developed patellar tendinopathy. The injury groups had a significantly greater peak vertical ground reaction force in freshmen and junior years (P = 0.020, ES = 0.13; P = 0.046, ES = 0.17), smaller knee flexion ROM in freshmen year (P = 0.002, ES = 0.10), and greater maximum knee flexion angular velocity in freshmen and junior year (P = 0.012, ES = 0.10; P = 0.001, ES = 0.35) during the horizontal landing phase before the takeoff of the jump compared to the no injury groups. The injury groups also had a significantly smaller knee flexion angle at initial contact during vertical landing phase after the takeoff of the jump in freshmen and junior years (P = 0.001, ES = 0.36; P = 0.001; ES = 0.37) during vertical landing phase.

Conclusion

Peak vertical ground reaction force, knee flexion angle at initial foot contact, knee flexion range of motion, and maximum knee flexion angular velocity are associated with patellar tendinopathy among male college basketball players in different school years.
Soil Health and Biodiversity Is Driven by Intensity of Organic Farming in Canada
Authors: Lynch Derek Henry
Published: July 2022

Organic farming is continuing to expand in Canada, with close to 6,000 producers farming over 2% of all agricultural land. There is insufficient evidence, however, of a trend toward larger average farm size and increasing specialization by these organic farms. This mini-review postulates that a gradient of intensity of farm management exists within organic farming sectors in Canada, with respect to cropping diversity, and tillage and nutrient utilization, and this gradient of intensity is a key determinant of agroecological outcomes. This variation in management approach and intensity reflects producer's individual perspectives on organic farming principles and practices, irrespective of farm scale. By directly influencing farm crop and vegetative diversity and cover, and farm nutrient status and carbon cycling, management intensity determines soil carbon storage and flux, soil health and biodiversity agroecological and ecosystem services, plus farm agronomic resilience. Demographic trends and perspectives of new entrants in organic farming are encouraging signs of an increasingly inclusive and socio-ecologically complex Canadian organic farming sector, which recognizes the agroecological implications of intensity of organic farm management across all production sectors.
Multi-Level Influences on Center-Pivot Irrigation Adoption in Alabama
Authors: Price Ashleigh N. , Pathak Ruchie , Guthrie Gregory M. , Kumar Mukesh , Moftakhari Hamed , Moradkhani Hamid , Nadolnyak Denis , Magliocca Nicholas R.
Published: July 2022

Rates of poverty and economic inequality in rural Alabama are among the nation's highest and increasing agricultural productivity can provide a needed boost to these communities. The transition from rain-fed to irrigation-fed (RFtoIF) agriculture has significantly increased farm productivity and profitability elsewhere in the United States. Despite this potential to enhance stability and resilience in rural economies, irrigated cropland accounts for only 5% of Alabama's total cropland as numerous barriers remain to irrigation adoption. To encourage RFtoIF transition, it is imperative to identify the challenges faced by individual farmers at farm, community, and state levels. This study presents a multi-level mixed effects survival analysis to identify the physiographic, socioecological, and economic factors that influence the location and timing of irrigation adoption. We integrate spatiotemporal cropland and climatological data with field-verified locations of center-pivot irrigation systems, local physiographic characteristics, and parcel-level surface water access and average well depth. Access to surface water, costs to access groundwater, and soil characteristics were generally important influences in all regions, but regions were differentiated by the extent to which new irrigation was more responsive to social influences vs. precipitation and price trends. Our findings also highlighted the diversity of farming conditions across the state, which suggested that diverse policy tools are needed that acknowledge the varying motivations and constraints faced by Alabama's farmers.
Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma
Authors: Vantucci Casey E. , Guyer Tyler , Leguineche Kelly , Chatterjee Paramita , Lin Angela , Nash Kylie E. , Hastings Molly Ann , Fulton Travis , Smith Clinton T. , Maniar Drishti , Frey Rubio David A. , Peterson Kaya , Harrer Julia Andraca , Willett Nick J. , Roy Krishnendu , Guldberg Robert E.
Published: July 2022

Bone non-unions resulting from severe traumatic injuries pose significant clinical challenges, and the biological factors that drive progression towards and healing from these injuries are still not well understood. Recently, a dysregulated systemic immune response following musculoskeletal trauma has been identified as a contributing factor for poor outcomes and complications such as infections. In particular, myeloid-derived suppressor cells (MDSCs), immunosuppressive myeloid-lineage cells that expand in response to traumatic injury, have been highlighted as a potential therapeutic target to restore systemic immune homeostasis and ultimately improve functional bone regeneration. Previously, we have developed a novel immunomodulatory therapeutic strategy to deplete MDSCs using Janus gold nanoparticles that mimic the structure and function of antibodies. Here, in a preclinical delayed treatment composite injury model of bone and muscle trauma, we investigate the effects of these nanoparticles on circulating MDSCs, systemic immune profiles, and functional bone regeneration. Unexpectedly, treatment with the nanoparticles resulted in depletion of the high side scatter subset of MDSCs and an increase in the low side scatter subset of MDSCs, resulting in an overall increase in total MDSCs. This overall increase correlated with a decrease in bone volume (P = 0.057) at 6 weeks post-treatment and a significant decrease in mechanical strength at 12 weeks post-treatment compared to untreated rats. Furthermore, MDSCs correlated negatively with endpoint bone healing at multiple timepoints. Single cell RNA sequencing of circulating immune cells revealed differing gene expression of the SNAb target molecule S100A8/A9 in MDSC sub-populations, highlighting a potential need for more targeted approaches to MDSC immunomodulatory treatment following trauma. These results provide further insights on the role of systemic immune dysregulation for severe trauma outcomes in the case of non-unions and composite injuries and suggest the need for additional studies on targeted immunomodulatory interventions to enhance healing.
Establishment and Application of a Real-Time Recombinase Polymerase Amplification Assay for the Detection of Avian Leukosis Virus Subgroup J
Authors: Qu Guanggang , Li Yun , Zhao Zhongwei , Miao Lizhong , Wei Feng , Tang Na , Xu Qingqing , Nair Venugopal , Yao Yongxiu , Shen Zhiqiang
Published: July 2022

Avian leukosis caused by avian leukosis virus (ALV), belonging to the genus Alpharetrovirus of the family Retroviridae, is associated with benign and malignant tumors in hemopoietic cells in poultry. Although several methods have been developed for ALV detection, most of them are not suitable for rapid on-site testing due to instrument limitations, professional operators, or the low sensitivity of the method. Herein, we described the real-time recombinase polymerase amplification (RPA) assay for rapid detection of ALV subgroup J (ALV-J). The major viral structural glycoprotein gp85, highly specific for the subgroup, was used as the molecular target for the real-time RPA assay. The results were obtained at 38°C within 20 min, with the detection sensitivity of 10 copies/μl of standard plasmid pMD18-T-gp85 as the template per reaction. Real-time RPA was capable of ALV-J-specific detection without cross-reaction with other non-targeted avian pathogens. Of the 62 clinical samples tested, the ALV-positive rates of real-time RPA, PCR, and real-time PCR were 66.13% (41/62), 59.68% (37/62), and 67.74% (42/62), respectively. The diagnostic agreement between real-time RPA and real-time PCR was 98.39% (61/62), and the kappa value was 0.9636. The developed real-time ALV-J assay seems promising for rapid and sensitive detection of ALV-J in diagnostic laboratories. It is suitable for on-site detection, especially in a poor resource environment, thus facilitating the prevention and control of ALV-J.
Commercial Extruded Plant-Based Diet Lowers Circulating Levels of Trimethylamine N-Oxide (TMAO) Precursors in Healthy Dogs: A Pilot Study
Authors: Cavanaugh Sarah M. , Cavanaugh Ryan P. , Streeter Renee , Vieira Aline B. , Gilbert Gregory E. , Ketzis Jennifer K.
Published: July 2022

Elevations in circulating trimethylamine N-oxide (TMAO) and its precursors are observed in humans and dogs with heart failure and are associated with adverse outcomes in people. Dietary intervention that reduces or excludes animal ingredients results in rapid reduction of plasma TMAO and TMAO precursors in people, but the impact of diet in dogs has not been studied. The objective of the current study was to determine the effect of diet on plasma TMAO and 2 of its precursors (choline and betaine) in dogs fed a commercial extruded plant-based diet (PBD) or a commercial extruded traditional diet (TD) containing animal and plant ingredients. Sixteen healthy adult mixed breed dogs from a university colony were enrolled in a randomized, 2-treatment, 2-period crossover weight-maintenance study. Mean (SD) age and body weight of the dogs were 2.9 years (± 1.7) and 14.5 kg (± 4.0), respectively. Eight dogs were female (3 intact, 5 spayed) and 8 dogs were male (4 intact, 4 castrated). Plasma choline, betaine and TMAO were quantified by LC-SID-MRM/MS at baseline, and after 4 weeks on each diet. Choline and betaine were also quantified in the diets. Plasma choline levels were significantly lower (P = 0.002) in dogs consuming a PBD (Mean ± SD, 6.8 μM ± 1.2 μM) compared to a TD (Mean ± SD, 7.8 μM ± 1.6 μM). Plasma betaine levels were also significantly lower (P = 0.03) in dogs consuming a PBD (Mean ± SD, 109.1 μM ± 25.3 μM) compared to a TD (Mean ± SD, 132.4 μM ± 32.5 μM). No difference (P = 0.71) in plasma TMAO was detected in dogs consuming a PBD (Median, IQR, 2.4 μM, 2.1 μM) compared to a TD (Median, IQR, 2.3 μM, 1.1 μM). Betaine content was lower in the PBD than in the TD while choline content was similar in the diets. Our findings indicate consumption of a commercial extruded PBD for 4 weeks reduces circulating levels of the TMAO precursors choline and betaine, but not TMAO, in healthy adult dogs.
Association Between Maternal Exposure to SO2 and Congenital Ear Malformations in Offspring: A Population-Based Case-Control Study in Liaoning Province, China
Authors: Yu Wei-Jun , Li Na , Gong Ting-Ting , Zhang Jia-Yu , Jiang Yu-Ting , Zhao Yu-Hong , Huang Yan-Hong , Li Jing , Liu Shu , Chen Yan-Ling , Li Li-Li , Jiang Cheng-Zhi , Chen Zong-Jiao , Wu Qi-Jun
Published: July 2022

Objectives: To examine associations between maternal sulfur dioxide (SO2) exposure and congenital ear malformations risk in offspring.

Methods: We surveyed 1676 cases with congenital ear malformations and 7950 controls from the Maternal and Child Health Certificate Registry of Liaoning Province between 2010 and 2015. SO2 concentrations were obtained from the Municipal Environment Protection Bureau of Liaoning Province. Multivariable logistic regression models and Restricted cubic splines (RCS) model were used to assess the aforementioned association.

Results: There were significant associations between maternal SO2 exposure and congenital ear malformations risk during the 3 months before conception (OR Q4 vs. Q1 = 1.93, 95% CI = 1.43–2.59) and the 3 months after conception (OR Q4 vs. Q1 = 1.63, 95% CI = 1.22–2.18). Similar results were obtained in the analysis of single-month exposure windows, except for the third month before conception and the third month after conception. Moreover, these findings were broadly consistent across subgroups and robust in sensitivity analyses. There were non-linear dose-response associations between SO2 exposure and congenital ear malformations based on restricted cubic spline model analysis.

Conclusion: Maternal SO2 exposure is associated with increased congenital ear malformations risk in offspring.
Novel Modularization Design and Intelligent Control of a Multifunctional and Flexible Baby Chair
Authors: Zhang Chunhong , Huang Shuai , Shen Weifeng , Dong Lin
Published: July 2022

The design and control of baby chairs have attracted great interest due to children’s increasing consumption market. As a human-robot interface, the features of baby chairs, such as their flexibility, comfortableness, safety, etc., are important factors that should be considered. Therefore, in this paper, to provide competent assistance to parents in taking care of their children, we propose a novel design and control scheme for improving children’s living goods and easing parents’ burden. Firstly, a novel modularization design method is introduced to redesign the shape and structure of the baby chair to cater to multifunctional demands. Flexible materials are chosen to adapt to different body shapes for the sake of safety and comfortableness. Moreover, a Cartesian impedance controller enhanced by a radial basis function neural network (RBFNN) is proposed to achieve a safe, smooth and accurate control of the baby chair with children sitting on it in various uncertain situations using integrated actuators. Both target posture control and periodic control of the chair are implemented to meet different practical requirements. The feasibility of both the chair design and its control is verified in the MATLAB simulation environment through reference tracking tasks. The experimental results demonstrate that our controller can achieve satisfactory performance by controlling the position error in a reasonable range and keeping the manipulation stable and smooth. With the increasing demand for baby chairs in the global children’s consumption market, we believe that the methodology proposed in this paper will attract more research and industry interest.
A Survey of Precision Formation Relative State Measurement Technology for Distributed Spacecraft
Authors: Zhang Zhang , Deng Lei , Feng Jiaqi , Chang Liang , Li Dong , Qin Yilin
Published: July 2022

High-precision relative-state measurement technology is one of the key technologies for achieving the precision formation flying of distributed spacecraft. This paper conducts a comprehensive analysis of the precision formation-flying projects of distributed spacecraft in various countries. In the context of practical application, the specific mission configuration, orbit distribution, measurement technology, and payload of the project are summarized. On this basis, the relative state measurement techniques are outlined for the first time, using non-autonomous measurement techniques, autonomous measurement techniques, and new composite relative measurement techniques. A detailed analysis of GNSS (Global Navigation Satellite System)—relative measurement, laser measurement, infrared measurement, RF measurement, visible light visual measurement, and multiple composite measurement methods is conducted. The applicable scenarios of each measurement method are thoroughly discussed from several aspects, such as the technical scheme, system design, accuracy requirements, advantages, and shortcomings. In addition, this paper proposes the concept of adopting a multidisciplinary optimization architecture from the perspective of the overall design of the precision formation of the distributed spacecraft. It enables relative-state measurement payload selection and property indicator optimization, on the premise of optimizing the overall formation performance. Finally, the optimization direction and future development trend of the spacecraft precision formation flight project and relative state measurement technology are established.
Aerial Platform Design Options for a Life-Finding Mission at Venus
Authors: Buchanan Weston P. , de Jong Maxim , Agrawal Rachana , Petkowski Janusz J. , Arora Archit , Saikia Sarag J. , Seager Sara , Longuski James ,   on behalf of the Venus Life Finder Mission Team
Published: July 2022

Mounting evidence of chemical disequilibria in the Venusian atmosphere has heightened interest in the search for life within the planet’s cloud decks. Balloon systems are currently considered to be the superior class of aerial platform for extended atmospheric sampling within the clouds, providing the highest ratio of science return to risk. Balloon-based aerial platform designs depend heavily on payload mass and target altitudes. We present options for constant- and variable-altitude balloon systems designed to carry out science operations inside the Venusian cloud decks. The Venus Life Finder (VLF) mission study proposes a series of missions that require extended in situ analysis of Venus cloud material. We provide an overview of a representative mission architecture, as well as gondola designs to accommodate a VLF instrument suite. Current architecture asserts a launch date of 30 July 2026, which would place an orbiter and entry vehicle at Venus as early as November 29 of that same year.
Multisatellite Task Allocation and Orbit Planning for Asteroid Terminal Defence
Authors: Luo Yuelong , Jiang Xiuqiang , Zhong Suchuan , Ji Yuandong , Sun Guohao
Published: July 2022

Near-Earth asteroids are a great threat to the Earth, especially potential rendezvous and collision asteroids. To protect the Earth from an asteroid collision, it is necessary to investigate the asteroid defence problem. An asteroid terminal defence method based on multisatellite interception was designed in this study. For an asteroid intruding in the sphere of the gravitational influence of the Earth, multiple interceptor satellites are used to apply a kinetic energy impulse to deflect the orbit of the asteroid. First, the effects of planned interception time and planned interception position on the required impulse velocity increment applied to the asteroid are assessed for interception opportunity selection. Second, multiple interceptor satellites are selected to perform the defence task from the on-orbit available interceptor satellite formation. An improved contract net protocol algorithm considering the Lambert orbital manoeuvre is designed to fulfil the task allocation and satellite orbit planning. Finally, simulation experiments demonstrate the rationale and effectiveness of the proposed method, which provides support for asteroid terminal defence technology.
Intelligent Agricultural Modelling of Soil Nutrients and pH Classification Using Ensemble Deep Learning Techniques
Authors: Escorcia-Gutierrez José , Gamarra Margarita , Soto-Diaz Roosvel , Pérez Meglys , Madera Natasha , Mansour Romany F.
Published: July 2022

Soil nutrients are a vital part of soil fertility and other environmental factors. Soil testing is an efficient tool used to evaluate the existing nutrient levels of soil and aid to compute the appropriate quantity of soil nutrients depending upon the fertility level and crop requirements. Since the conventional soil nutrient testing models are not feasible in real time applications, an efficient soil nutrient, and potential of hydrogen (pH) prediction models are essential to improve overall crop productivity. In this aspect, this paper aims to design an intelligent soil nutrient and pH classification using weighted voting ensemble deep learning (ISNpHC-WVE) technique. The proposed ISNpHC-WVE technique aims to classify the existence of nutrients and pH levels exist in the soil. In addition, three deep learning (DL) models namely gated recurrent unit (GRU), deep belief network (DBN), and bidirectional long short term memory (BiLSTM) were used for the predictive analysis. Moreover, a weighted voting ensemble model was employed which allows a weight vector on every DL model of the ensemble depending upon the attained accuracy on every class. Furthermore, the hyperparameter optimization of the three DL models was performed using manta ray foraging optimization (MRFO) algorithm. For investigating the enhanced predictive performance of the ISNpHC-WVE technique, a comprehensive simulation analysis takes place to examine the pH and soil nutrient classification performance. The experimental results showcased the better performance of the ISNpHC-WVE technique over the recent techniques with accuracy of 0.9281 and 0.9497 on soil nutrient and soil pH classification. The proposed model can be utilized as an effective tool to improve productivity in agriculture by proper soil nutrient and pH classification.
Arbuscular Mycorrhizal Fungi Inoculation Improves Flower Yield and Postharvest Quality Component of Gerbera Grown under Different Salinity Levels
Authors: Othman Yahia A. , Tahat Monther , Alananbeh Kholoud M. , Al-Ajlouni Malik
Published: July 2022

High salinity levels of irrigated water and the accumulation of salt over time in the soil is a major concern worldwide, including in Jordan. The objective of this two-year study was to assess the influence of arbuscular mycorrhizal fungi (AMF) inoculation on the physiology, yield, and flower quality of gerbera (Gerbera jamesonii cvs. Beaudine and Palm Beach) under different salinity levels (0.0, 20.0 and 40.0 mM-NaCl). The study was arranged in a randomized complete block design with five replicates. During the experimental period (2018–2019), chlorophyll content index (SPAD), leaf gas exchange (photosynthesis, Pn; stomatal conductance, gs; transpiration, E), flower yield, flower quality (pedicel length and diameter, number of days to flowering, flower diameter, and vase life), root sporulation, and colonization were measured. Irrigation with saline water (20 and 40 mM-NaCl) significantly increased salt accumulation in soil. The mean soil electrical conductivity (EC) after two growing seasons for the 20 mM-NaCl treatment was 2.9 dS m−1 and 4.4 dS m−1 for the 40 mM. High salinity level (40 mM-NaCl) reduced root AMF sporulation by 53–62% and colonization by 12–25% across cultivars. Interestingly, root colonization was higher than 50% across salinity level and in both cultivars. Saline water at 40 mM-NaCl significantly reduced SPAD, Pn, gs, E, flower yield, and quality component, especially vase life. Interestingly, leaf chlorophyll content index from AMF-inoculated plants was significantly higher than uninoculated ones across cultivars at the second growing season. In addition, inoculation with AMF significantly increased yield in both ‘Beaudine’ (34–40%) and ‘Palm Beach’ (42–44%) cultivars and across the study period, 2018 to 2019. In addition, AMF increased vase life in ‘Beaudine’ by 19% to 28% and in ‘Palm Beach’ by 21% to 22%. Overall, our results revealed that gerbera growers can increase their flower yield and postharvest flower quality component (vase life) under saline conditions (soil EC < 4.4 dS m−1) by inoculating the seedlings with AMF.
The Dilemma of Fraudulent Pesticides in the Agrifood Sector: Analysis of Factors Affecting Farmers’ Purchasing Behavior in Egypt
Authors: Kassem Hazem S. , Hussein Mohamed A. , Ismail Hamed
Published: July 2022

Fraudulent pesticides suggest a solemn risk to sustainable agricultural production, environmental sustainability, and human health due to their unrevealed composition and quality. Nonetheless, their large-scale utilization in the agrifood sector relies on many factors, such as personal, institutional, and legislative ones. This study aimed to evaluate farmers’ perceptions of fraudulent pesticides and examine their marketability elements. The data came from 394 farmers’ structured questionnaires from Dakahlia governorate, Egypt. The factorial analysis revealed beliefs, health and environmental risks, quality recognition, price, and policies as the critical drivers for buying fraudulent pesticides. The cluster analysis disclosed two varied farmer segments—“conventional” and “conscious”—based on perception. “conventional farmers” signify 59.9% of the sample and reveal typical farmer behaviors and give more attention to factors such as beliefs and product price. Contrarily, “conscious farmers” symbolize a more sentient group about policy, product quality, and health and environmental issues. Significant differences (p < 0.01) occurred between the two segments, corresponding to their education, farming activity, farm size, and farming experience. The findings suggest reinforcing the extant pesticide laws and regulations’ administration mechanisms, implementing deliberate measures to increase public awareness of the consequences resulting from fraudulent pesticide use, and improving recognition behavior by detecting fraudulent pesticides with digital technologies among all stakeholders.
Genome-Wide Analysis of the Rice Gibberellin Dioxygenases Family Genes
Authors: He Yurong , Liu Wei , Huang Zhihao , Huang Jishuai , Xu Yanghong , Zhang Qiannan , Hu Jun
Published: July 2022

Gibberellins (GAs), a pivotal plant hormone, play fundamental roles in plant development, growth, and stress response. In rice, gibberellin-dioxygenases (GAoxes) are involved in the biosynthesis and deactivation of gibberellins. However, a comprehensive genome-wide analysis of GA oxidases in rice was not uncovered. Here, a total of 80 candidate OsGAox genes were identified and 19 OsGAox genes were further analyzed. Studies on those 19 OsGAox genes, including phylogenetic tree construction, analysis of gene structure, exploration of conserved motifs and expression patterns, were conducted. Results showed that the GAox genes in Arabidopsis and rice were divided into four subgroups and shared some common features. Analysis of gene structure and conserved motifs revealed that splicing phase and motifs were well conserved during the evolution of GAox genes in Arabidopsis and rice, but some special conserved motifs possessed unknown functions need to be further studied. Exploration of expression profiles from RNA-seq data indicated that each GAox gene had tissue-specific expression patterns, although they varied greatly. The expression patterns of these genes under GA3 treatment revealed that some genes, such as OsGA2ox1, OsGA2ox3, OsGA2ox4, OsGA2ox7, OsGA20ox1, and OsGA20ox4, may play a major role in regulating the level of bioactive GA. Taken together, our study provides a comprehensive analysis of the GAox gene family and will facilitate further studies on their roles in rice growth and development so that these genes can be better exploited.
General Equilibrium with Price Adjustments—A Dynamic Programming Approach
Authors: Lindgren Jussi
Published: July 2022

This research article develops a dynamic framework for the Walrasian pure exchange economy and thus extends the static Walrasian general equilibrium theory into a dynamic one with price adjustments. An evolution equation for the price vector is derived from dynamic programming considerations. The economy tries to move from disequilibrium to general equilibrium by minimizing certain cost functional. The cost functional measures transactions costs and the total expenditure of agents when they optimize individually. Price determination is directly related to a gradient search. The general equilibrium is shown to be stable in the sense of Lyapunov if price adjustments can be large, when needed. The conditional stability could be one reason for volatility clustering in financial time series.
Adaptability and Evolution of Gobiidae: A Genetic Exploration
Authors: Shang Yongquan , Wang Xibao , Liu Gang , Wu Xiaoyang , Wei Qinguo , Sun Guolei , Mei Xuesong , Dong Yuehuan , Sha Weilai , Zhang Honghai
Published: July 2022

The Gobiidae family occupy one of the most diverse habitat ranges of all fishes. One key reason for their successful colonization of different habitats is their ability to adapt to different energy demands. This energy requirement is related to the ability of mitochondria in cells to generate energy via oxidative phosphorylation (OXPHOS). Here, we assembled three complete mitochondrial genomes of Rhinogobius shennongensis, Rhinogobius wuyanlingensis, and Chaenogobius annularis. These mitogenomes are circular and include 13 protein-coding genes (PCGs), two rRNAs, 22 tRNAs, and one non-coding control region (CR). We used comparative mitochondrial DNA (mtDNA) genome and selection pressure analyses to explore the structure and evolutionary rates of Gobiidae mitogenomics in different environments. The CmC model showed that the ω ratios of all mtDNA PCGs were <1, and that the evolutionary rate of adenosine triphosphate 8 (atp8) was faster in Gobiidae than in other mitochondrial DNA PCGs. We also found evidence of positive selection for several sites of NADH dehydrogenase (nd) 6 and atp8 genes. Thus, divergent mechanisms appear to underlie the evolution of mtDNA PCGs, which might explain the ability of Gobiidae to adapt to diverse environments. Our study provides new insights on the adaptive evolution of Gobiidae mtDNA genome and molecular mechanisms of OXPHOS.