bluuebunny/crossref_metadata_2025 huggingface dataset:
Background Instance-Based Copy-Paste Data Augmentation for Object Detection
Authors: Zhang Liuying , Xing Zhiqiang , Wang Xikun
Published: September 2023

In supervised deep learning object detection, the quantity of object information and annotation quality in a dataset affect model performance. To augment object detection datasets while maintaining contextual information between objects and backgrounds, we proposed a Background Instance-Based Copy-Paste (BIB-Copy-Paste) data augmentation model. We devised a method to generate background pseudo-labels for all object classes by calculating the similarity between object background features and image region features in Euclidean space. The background classifier, trained with these pseudo-labels, can guide copy-pasting to ensure contextual relevance. Several supervised object detectors were evaluated on the PASCAL VOC 2012 dataset, achieving a 1.1% average improvement in mean average precision. Ablation experiments with the BlitzNet object detector on the PASCAL VOC 2012 dataset showed an improvement of mAP by 1.19% using the proposed method, compared to a 0.18% improvement with random copy-paste. Images from the MS COCO dataset containing objects of the same classes as in PASCAL VOC 2012 were also selected for object pasting experiments. The contextual relevance of pasted objects demonstrated our model’s effectiveness and transferability between datasets with same class of objects.
Anomaly Detection Model of Network Dataflow Based on an Improved Grey Wolf Algorithm and CNN
Authors: Wang Liting , Chen Qinghua , Song Chao
Published: September 2023

With the popularization of the network and the expansion of its application scope, the problem of abnormal network traffic caused by network attacks, malicious software, traffic peaks, or network device failures is becoming increasingly prominent. This problem not only leads to a decline in network performance and service quality but also may pose a serious threat to network security. This paper proposes a hybrid data processing model based on deep learning for network anomaly detection to improve anomaly detection performance. First, the Grey Wolf optimization algorithm is improved to select high-quality data features, which are then converted to RGB images and input into an anomaly detection model. An anomaly detection model of network dataflow based on a convolutional neural network is designed to recognize network anomalies, including DoS (Denial of Service), R2L (Remote to Local), U2R (User to Root), and Probe (Probing). To verify the effectiveness of the improved Grey Wolf algorithm and the anomaly detection model, we conducted experiments on the KDD99 and UNSW-NB15 datasets. The proposed method achieves an average detection rate of 0.986, which is much higher than all the counterparts. Experimental results show that the accuracy and the detection rates of our method were improved, while the false alarm rate has been reduced, proving the effectiveness of our approach in network anomaly classification tasks.
Design of Miniaturized SIW Filter Loaded with Improved CSRR Structures
Authors: Huang Xiaolong
Published: September 2023

In recent years, Split-Ring Resonators (SRRs) and Complementary Split-Ring Resonators (CSRRs) have gained significant attention for their unique electromagnetic properties, such as negative permeability and negative permittivity, making them promising candidates for advanced microwave devices. This paper presents the design and analysis of a substrate-integrated waveguide (SIW) filter using CSRR structures for miniaturization. The improved CSRR unit can be easily integrated on the surface of the SIW, making it an ideal candidate for the design of compact SIW filters. In this paper, an improved CSRR-loaded SIW filter is designed and analyzed based on its equivalent lumped parameter model. A filter with a center frequency at 22.6 GHz is designed. Several transmission zeros (TZs) are also realized to improve the skirt selectivity of the filter. The design process involves theoretical analysis and electromagnetic simulations to optimize the dimensions of the CSRR resonators to achieve the desired filter characteristics. The measured and simulated results show good agreement, confirming the effectiveness of the proposed improved CSRR-loaded SIW filter. The successful implementation of the improved CSRR-loaded SIW filter demonstrates its potential for achieving miniaturization and enhanced performance in advanced microwave applications.
Collaborative Service Restoration with Network Reconfiguration for Resilience Enhancement in Integrated Electric and Heating Systems
Authors: Wang Jinhao , Ge Huaichang , Yang Yang , Pan Zhaoguang , Liu Yizhao , Zhao Haotian
Published: September 2023

Coordinated fault recovery is essential for the resilience enhancement of integrated electric and heating systems (IEHS) following natural catastrophes as the linkage of the power distribution system (PDS) and district heating system becomes tighter. DHS reconfiguration is a viable method for service restoration because it could adjust the energy between energy sources and achieve uninterrupted energy supplies. In this paper, a collaborative service restoration model considering DHS reconfiguration is proposed to achieve better recovery after natural disasters. DHS reconfiguration could guarantee interrupted power supply in non-fault regions by shifting electric loads between power sources and accomplish optimal service restoration by adjusting the power output of combined heat and power units. Numerous case studies are undertaken to demonstrate the performance of coordinated reconfiguration on resilience enhancement and to confirm the efficacy of the proposed paradigm.
Recent Advances in Electrochemical Enzyme-Based Biosensors for Food and Beverage Analysis
Authors: Wijayanti Sudarma Dita , Tsvik Lidiia , Haltrich Dietmar
Published: September 2023

Food analysis and control are crucial aspects in food research and production in order to ensure quality and safety of food products. Electrochemical biosensors based on enzymes as the bioreceptors are emerging as promising tools for food analysis because of their high selectivity and sensitivity, short analysis time, and high-cost effectiveness in comparison to conventional methods. This review provides the readers with an overview of various electrochemical enzyme-based biosensors in food analysis, focusing on enzymes used for different applications in the analysis of sugars, alcohols, amino acids and amines, and organic acids, as well as mycotoxins and chemical contaminants. In addition, strategies to improve the performance of enzyme-based biosensors that have been reported over the last five years will be discussed. The challenges and future outlooks for the food sector are also presented.
Effects of Wooden Breast Syndrome in Broiler Chicken on Sarcoplasmic, Myofibrillar, and Connective Tissue Proteins and Their Association with Muscle Fiber Area
Authors: Li Binbin , Lindén Jere , Puolanne Eero , Ertbjerg Per
Published: September 2023

This study was conducted on chicken pectoralis major muscle with different wooden breast severity in combination with different sampling locations to investigate the effects of wooden breast syndrome on protein traits and total myofiber area, and their associations. Contents of sarcoplasmic, salt-soluble myofibrillar and salt-insoluble protein and proportion of total myofiber area significantly declined with increasing severity in the superficial part of muscle, whereas the amount of heat-soluble/insoluble collagen and protein denaturation as well as the area of degenerated myofibers, connective tissue and cellular infiltrates increased. Myofibril protein content indicators showed strong positive correlations to total myofiber area. Moreover, PCA results indicated that severe wooden breast is positively linked to muscle collagen content and to protein denaturation. Our results suggest that decrease in sarcoplasmic and myofibrillar proteins is associated with reduction of myofiber area. In turn, the muscle fibers are replaced by connective tissue, accompanied by excessive myofibrillar and sarcoplasmic protein denaturation.
Study of Polyvinyl Alcohol Hydrogels Applying Physical-Mechanical Methods and Dynamic Models of Photoacoustic Signals
Authors: Ramírez-Chavarría Roberto G. , Pérez-Pacheco Argelia , Terán Emiliano , Quispe-Siccha Rosa M.
Published: September 2023

This study aims to analyze the physical-mechanical properties and dynamic models of tissue-simulating hydrogels, specifically the photoacoustic (PA) response signals, by varying the concentrations of polyvinyl alcohol (PVA) and molecular weight (MW). A state-space model (SSM) is proposed to study the PVA hydrogels to retrieve the PA-related signal’s damping ratio and natural frequency. Nine box-shaped PVA hydrogels containing saline solution were used, with five concentrations of PVA (7, 9, 12, 15, 20%) for MW1 and four for MW2. The results indicated that the concentration of PVA and MW played an important role in the PA wave’s amplitude, arrival time, and speed of sound over the hydrogels. The SSM parameters showed that increasing PVA and MW concentrations improved the hydrogels’ ability to absorb and transfer energy under the PA effect. These parameters were also found to be correlated with density and modulus of elasticity. Additionally, the concentrations of PVA and MW affected the absorption and optical scattering coefficients. The physical-mechanical properties, including porosity, density, and modulus of elasticity, improved as the concentration of PVA and MW increased. The ultimate goal of this study is to develop hydrogels as phantoms that can be used for tissue simulation and imaging.
Expected Changes in Rainfall-Induced Landslide Activity in an Italian Archaeological Area
Authors: Volpe Evelina , Gariano Stefano Luigi , Ciabatta Luca , Peiro Yaser , Cattoni Elisabetta
Published: September 2023

Cultural heritage is one of the most exceptional resources characterizing the Italian territory. Archaeological heritage, i.e., the archaeological sites with different types of archaeological artifacts, strongly contributes to enriching the national and international cultural heritage. Nevertheless, it is constantly exposed to external factors, such as natural deterioration, anthropic impact, and climate-related hazards, which may compromise its conservation. In Italy, many archaeological areas are affected by significant soil settlements that involve a large part of monuments. This paper focuses on the landslide hazard assessment of the archaeological site of Pietrabbondante (Molise region, Italy). The impact of the expected rainfall regimes, according to the EURO-CORDEX projections, on slope stability conditions were evaluated through the application of a physically based model that couples a hydraulic and a mechanical model to evaluate slope stability evolution due to pore pressure changes. Given the unavoidable lack of knowledge of the geotechnical soil properties in an archaeological heritage area, the proposed method considered the random uncertainty of soil parameters by means of a probabilistic approach in order to assess the stability conditions in terms of probability of occurrence of a landslide. The results of this study provide a reference for the safety assessment and preventive conservation of archaeological areas characterized by high cultural value.
Market Reaction to Corporate Releases and News Articles: Evidence from Thailand’s Stock Market
Authors: Supawat Likittanawong , Arnat Leemakdej
Published: September 2023

Studies that quantify the price impact of the information in corporate press releases and news articles mainly focus on quantitative news, such as earnings announcements, dividends, and financial performance-related events, but leave out other corporate news events. Those that do so generally focus on one source of information and do not compare the price impacts from different information sources. Our study aimed to extend previous studies by quantifying and comparing market reactions to corporate press releases and news articles across different news categories. We classified and categorized 100,960 news items, encompassing 26,546 corporate press releases and 74,414 news articles, of 615 firms in the Stock Exchange of Thailand between 1 January 2017 and 31 December 2019. These news items were classified into categories based on the information contained in corporate press releases and news articles. We then studied the market reactions to these news categories. We found that the price impact from corporate releases is sustained for both positive and negative news categories. Our results also show that the positive price impact for news reported by the media tends to reverse, consistent with prior studies. In contrast, the negative price impact from news articles holds; this result differs from previous studies. Our data also show that managers tend to leak and recycle good news while the release of bad news is delayed.
Efficient Disposal of Basic Fuchsin Dye from Aqueous Media Using ZrO2/MgMn2O4/Mg(Mg0.333Mn1.333)O4 as a Novel and Facilely Synthesized Nanocomposite
Authors: Al-Wasidi Asma S. , Khairy Mohamed , Abdulkhair Babiker Y. , Abdelrahman Ehab A.
Published: September 2023

In this work, amorphous and crystalline novel products based on Zr, Mg, and Mn were facilely fabricated through the Pechini sol–gel procedure using inexpensive chemicals and an uncomplicated apparatus. Also, these products showed high efficiency as novel adsorbents in getting rid of basic fuchsin dye from aqueous solutions. The adsorbent, which was fabricated before calcination, was abbreviated as KE. In addition, the adsorbents, which were created at 500 and 700 °C, were designated as KE500 and KE700, respectively. The created adsorbents were characterized using high-level transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), N2 adsorption/desorption analyzer, and field emission scanning electron microscope (FE-SEM). The XRD showed that the KE adsorbent is amorphous, whereas the KE500 and KE700 adsorbents are mixtures of ZrO2, MgMn2O4, and Mg(Mg0.333Mn1.333)O4 nanostructures. The HR-TEM exhibited that the KE adsorbent consists of very fine irregular shapes, whereas the KE500 adsorbent contains quasi-spherical particles with a mean diameter of 45.16 nm. Furthermore, the HR-TEM exhibited that the KE700 adsorbent consists of polyhedral shapes with a mean diameter of 76.28 nm. Furthermore, the BET surface area of the KE, KE500, and KE700 adsorbents is 67.85, 20.15, and 13.60 m2/g, respectively. Additionally, the elimination of basic fuchsin dye by the KE, KE500, and KE700 adsorbents is exothermic, physical in nature, and follows the pseudo-first-order as well as Langmuir equations. Further, the maximum uptake capabilities of the KE, KE500, and KE700 adsorbents toward basic fuchsin dye are 239.81, 174.83, and 93.19 mg/g, respectively.
Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms
Authors: Nana Petroula , Jama Katarzyna , Kölbel Tilo , Spanos Konstantinos , Panuccio Giuseppe , Jakimowicz Tomasz , Rohlffs Fiona
Published: September 2023

Introduction: Females are at increased risk of mortality compared to males after complex endovascular aortic repair. This study aims to examine sex-related peri-operative and follow-up outcomes in patients managed with the t-Branch device. Methods: A two-center retrospective analysis of patients managed with the off-the-shelf t-Branch device (Cook Medical Inc., Bjaeverskov, Denmark) between 1 January 2014 and 30 September 2020 was performed. Primary outcomes were sex-comparative 30-day mortality, major adverse events (MAEs) and spinal cord ischemia (SCI). Results: A total of 542 patients were included; 28.0% were females. Urgent repair and type I–III thoracoabdominal aneurysms were more common among females (52.6% vs. 34%, p = 0.01, and 57.1% vs. 35.8%, p = 0.004). Technical success was similar (97.4% vs. 96.9%, p = 0.755), as well as early mortality (16.2% in females vs. 10.8% in males; p = 0.084). SCI rates were similar between groups (13.6% vs. 9.2% p = 0.183). MAEs were more common in females; 33.7% vs. 21.4% (p = 0.022). Multivariate analysis did not identify sex as an independent predictor of adverse events. The 12-month survival rate was 75.7% (SE 0.045) for females and 84.1% (SE 0.026) for males (log rank, p = 0.10). Conclusions: Sex was not detected as an independent factor of mortality, MAEs and SCI within patients managed with the t-Branch device. Feasibility was high in both groups. No significant difference was shown in survival during the 12-month follow-up.
Effectiveness and Tolerability of Ectoin® Mouth and Throat Spray Althaea Honey (ERS09) for Sore Throat due to Acute Pharyngitis and Dry Cough: A Multicentre, Actively Controlled, Open Label Study in Germany
Authors: Roventa Don Lorenzo Constantin , Pieper-Fürst Ursula , Acikel Cengizhan , Santos Dunia , Sent Ulrike , Mösges Ralph
Published: September 2023

Acute pharyngitis can cause sore throat. This multicentre, active-controlled, randomised, open-label, and parallel-group study, conducted according to the German Medical Devices Act, compared the effectiveness and tolerability of ERS09 mouth and throat spray with a well-established device for the treatment of sore throat caused by acute pharyngitis and dry cough. Patients were randomised 1:1 into ERS09/comparator groups (EMSER® Sore Throat Spray) for 7 ± 2 days. Patients and investigators reported effectiveness (change in total symptom score [TSS]) and safety endpoints (incidence of adverse events [AEs]; adverse device effects [ADEs]). A total of 186 patients were included (ERS09: n = 92; comparator: n = 94). The baseline-adjusted mean TSS over 7 days was −90.14 and −74.91 in the ERS09 and comparator groups, respectively (p < 0.05). The majority of patients reached a 50% reduction in symptoms by day 6 (ERS09 = 78.85; comparator = 75.8%). Most patients reported a soothing effect within five minutes (ERS09 = 82%; comparator = 71%). Improvements in individual symptoms were similar with no significant differences between groups; more patients in the ERS09 group reported an improvement in pharyngeal redness/swelling. Three AEs unrelated to medication, one ADE following ERS09, and no serious AE/ADE were reported. ERS09 was as well tolerated and effective as the established device, showing greater improvement in the management of some symptoms and greater patient preference.
Invasive Phenoprofiling of Acute-Myocardial-Infarction-Related Cardiogenic Shock
Authors: Ortega-Hernández Jorge A. , González-Pacheco Héctor , Argüello-Bolaños Jardiel , Arenas-Díaz José Omar , Pérez-López Roberto , García-Arias Mario Ramón , Gopar-Nieto Rodrigo , Sierra-Lara-Martínez Daniel , Araiza-Garaygordobil Diego , Manzur-Sandoval Daniel , Soliz-Uriona Luis Alejandro , Astudillo-Alvarez Gloria Monserrath , Hernández-Montfort Jaime , Arias-Mendoza Alexandra
Published: September 2023

Background: Studies had previously identified three cardiogenic shock (CS) phenotypes (cardiac-only, cardiorenal, and cardiometabolic). Therefore, we aimed to understand better the hemodynamic profiles of these phenotypes in acute myocardial infarction-CS (AMI-CS) using pulmonary artery catheter (PAC) data to better understand the AMI-CS heterogeneity. Methods: We analyzed the PAC data of 309 patients with AMI-CS. The patients were classified by SCAI shock stage, congestion profile, and phenotype. In addition, 24 h hemodynamic PAC data were obtained. Results: We identified three AMI-CS phenotypes: cardiac-only (43.7%), cardiorenal (32.0%), and cardiometabolic (24.3%). The cardiometabolic phenotype had the highest mortality rate (70.7%), followed by the cardiorenal (52.5%) and cardiac-only (33.3%) phenotypes, with significant differences (p < 0.001). Right atrial pressure (p = 0.001) and pulmonary capillary wedge pressure (p = 0.01) were higher in the cardiometabolic and cardiorenal phenotypes. Cardiac output, index, power, power index, and cardiac power index normalized by right atrial pressure and left-ventricular stroke work index were lower in the cardiorenal and cardiometabolic than in the cardiac-only phenotypes. We found a hazard ratio (HR) of 2.1 for the cardiorenal and 3.3 for cardiometabolic versus the cardiac-only phenotypes (p < 0.001). Also, multi-organ failure, acute kidney injury, and ventricular tachycardia/fibrillation had a significant HR. Multivariate analysis revealed that CS phenotypes retained significance (p < 0.001) when adjusted for the Society for Cardiovascular Angiography & Interventions score (p = 0.011) and ∆congestion (p = 0.028). These scores independently predicted mortality. Conclusions: Accurate patient prognosis and treatment strategies are crucial, and phenotyping in AMI-CS can aid in this effort. PAC profiling can provide valuable prognostic information and help design new trials involving AMI-CS.
Diagnostic Work-Up in Patients with Nonbacterial Thrombotic Endocarditis
Authors: Tonutti Antonio , Scarfò Iside , La Canna Giovanni , Selmi Carlo , De Santis Maria
Published: September 2023

Nonbacterial thrombotic endocarditis (NBTE) is a form of endocarditis that occurs in patients with predisposing conditions, including malignancies, autoimmune diseases (particularly antiphospholipid antibody syndrome, which accounts for the majority of lupus-associated cases), and coagulation disturbances for which the correlation with classical determinants is unclear. The condition is commonly referred to as “marantic”, “verrucous”, or Libman–Sacks endocarditis, although these are not synonymous, representing clinical–pathological nuances. The clinical presentation of NBTE involves embolic events, while local valvular complications, generally regurgitation, are typically less frequent and milder compared to infective forms of endocarditis. In the past, the diagnosis of NBTE relied on post mortem examinations, while at present, the diagnosis is primarily based on echocardiography, with the priority of excluding infective endocarditis through comprehensive microbiological and serological tests. As in other forms of endocarditis, besides pathology, transesophageal echocardiography remains the diagnostic standard, while other imaging techniques hold promise as adjunctive tools for early diagnosis and differentiation from infective vegetations. These include cardiac MRI and 18FDG-PET/CT, which already represents a major diagnostic criterion of infective endocarditis in specific settings. We will herein provide a comprehensive review of the current knowledge on the clinics and therapeutics of NBTE, with a specific focus on the diagnostic tools.
Reducing the Risks of Esophagectomies: A Retrospective Comparison of Hybrid versus Full-Robotic-Assisted Minimally Invasive Esophagectomy (RAMIE) Approaches
Authors: Hoelzen Jens Peter , Frankauer Brooke E. , Szardenings Carsten , Roy Dhruvajyoti , Pollmann Lukas , Fortmann Lukas , Merten Jennifer , Rijcken Emile , Juratli Mazen A. , Pascher Andreas
Published: September 2023

This retrospective analysis aimed to assess and compare the short-term perioperative outcomes and morbidity of hybrid and full-Robotic-Assisted Minimally Invasive Esophagectomy (RAMIE) surgical techniques. A total of 168 robotic-assisted Ivor Lewis esophagectomy procedures performed at Muenster University Hospital were included in the study, with 63 cases in the hybrid group and 105 cases in the full-robotic group. Demographic factors, comorbidities, and tumor stages showed no significant differences between the two groups. However, the full-RAMIE technique demonstrated superiority in terms of overall operative time, postoperative pain levels, and patient morphine consumption. Additionally, the full-RAMIE group exhibited better perioperative outcomes, with significantly shorter ICU stays and fewer occurrences of pneumonias and severe complications. While there was a trend favoring the full-RAMIE technique in terms of severe postoperative complications and anastomotic insufficiencies, further research is required to establish it as the gold standard surgical technique for Ivor Lewis esophagectomy.
Retromolar Triangle Anesthesia Technique: A Feasible Alternative to Classic?
Authors: Roi Ciprian Ioan , Roi Alexandra , Nicoară Adrian , Motofelea Alexandru Cătălin , Riviș Mircea
Published: September 2023

Anesthetic techniques play an important role in the outcome of the therapeutic procedures in dentistry. Although inferior alveolar nerve block (IANB) anesthesia is currently the most often used, there are situations that imply the need of an alternative anesthesia technique to overcome the potential risks and complications. The aim of the study was to evaluate the efficacy of the retromolar triangle anesthesia technique in achieving the desired nerve block, while evaluating the duration of the anesthesia for the included cases. Methods: The present prospective study included 50 subjects that had indication of inferior molar extraction. The performed anesthesia technique for these cases was the retromolar triangle approach, and the analyzed parameters for evaluating the efficacy of this anesthesia technique were the positive nerve block of the branches involved in the area (inferior alveolar, buccal, and lingual nerves) and the duration of the anesthesia. Results: The efficiency of the retromolar triangle anesthesia technique was positive in 64% of the cases for the inferior alveolar nerve, 46% of the cases for the lingual nerve, and 22% of the cases for the buccal nerve. The duration of the anesthesia revealed a mean value of 72.4 min, suggesting that the duration is an essential factor in its effectiveness. Conclusions: Retromolar triangle anesthesia can be a viable option for clinicians, offering a simple and easy approach for the management of clinical cases.
Comparison of the Visual Outcomes of Enhanced and Standard Monofocal Intraocular Lens Implantations in Eyes with Early Glaucoma
Authors: Nam Jeoung Woo , Lee Jong Hoon , Zhang Haowei , Sung Mi Sun , Park Sang Woo
Published: September 2023

This study aimed to compare the efficacies and safety of enhanced and standard monofocal intraocular lenses (IOLs) in eyes with early glaucoma. Patients with concurrent cataracts and open-angle glaucoma (OAG) were enrolled. They underwent cataract surgery with IOL implantation. The comprehensive preoperative ophthalmic examination included the manifest refraction; monocular uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA), and uncorrected near visual acuity (UNVA); visual field (VF); and contrast sensitivity (CS); defocus curves and questionnaires were assessed three months postoperatively. Totals of 34 and 38 patients had enhanced and standard monofocal IOLs, respectively. The enhanced monofocal IOL provided better UIVA than the standard monofocal IOL (p = 0.003) but similar UDVA, CDVA, and UNVA. The enhanced monofocal IOL had more consistent defocus curves than the standard monofocal IOL, especially at −1 (p = 0.042) and −1.5 (p = 0.026) diopters. The enhanced monofocal IOL provided better satisfaction (p = 0.019) and lower spectacle dependence (p = 0.004) than the standard monofocal IOL for intermediate vision, with similar VF and CS outcomes. In conclusion, enhanced monofocal IOLs are recommended for patients with OAG because they provide better intermediate vision, higher satisfaction, and lower dependence on spectacles than standard monofocal IOLs, without worsening other visual outcomes.
Might Gut Microbiota Be a Target for a Personalized Therapeutic Approach in Patients Affected by Atherosclerosis Disease?
Authors: Ciccone Marco Matteo , Lepera Mario Erminio , Guaricci Andrea Igoren , Forleo Cinzia , Cafiero Concetta , Colella Marica , Palmirotta Raffele , Santacroce Luigi
Published: September 2023

In recent years, the increasing number of studies on the relationship between the gut microbiota and atherosclerosis have led to significant interest in this subject. The gut microbiota, its metabolites (metabolome), such as TMAO, and gut dysbiosis play an important role in the development of atherosclerosis. Furthermore, inflammation, originating from the intestinal tract, adds yet another mechanism by which the human ecosystem is disrupted, resulting in the manifestation of metabolic diseases and, by extension, cardiovascular diseases. The scientific community must understand and elucidate these mechanisms in depth, to gain a better understanding of the relationship between atherosclerosis and the gut microbiome and to promote the development of new therapeutic targets in the coming years. This review aims to present the knowledge acquired so far, to trigger others to further investigate this intriguing topic.
Evaluating the Predictive Value of Diagnostic Testicular Biopsy for Sperm Retrieval Outcomes in Men with Non-Obstructive Azoospermia
Authors: Kaltsas Aris , Markou Eleftheria , Zachariou Athanasios , Dimitriadis Fotios , Symeonidis Evangelos N. , Zikopoulos Athanasios , Mamoulakis Charalampos , Tien Dung Mai Ba , Takenaka Atsushi , Sofikitis Nikolaos
Published: September 2023

Background: Non-obstructive azoospermia (NOA) presents a challenge in male infertility management. This study aimed to assess the efficacy of diagnostic testicular biopsy (DTB) in predicting sperm retrieval success via therapeutic testicular biopsy (TTB) and to understand the role of systemic inflammation in microdissection testicular sperm extraction (mTESE) outcomes. Methods: A retrospective analysis was conducted on 50 NOA males who underwent mTESE at the University of Ioannina’s Department of Urology from January 2017 to December 2019. All participants underwent thorough medical evaluations, including semen analyses and endocrinological assessments. Results: DTB did not detect spermatozoa in half of the patients who later showed positive sperm findings in TTB. Preoperative variables, such as age, plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), prolactin (PRL), estradiol (E2), and inflammation biomarkers (neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–eosinophil ratio (MER)), were not consistently predictive of sperm retrieval success. Notably, TTB-negative patients had elevated NLR and PLR values, suggesting a possible link between systemic inflammation and reduced sperm retrieval during mTESE. Conclusions: The findings question the necessity of an initial DTB, which might provide misleading results. A negative DTB should not deter further TTB or intracytoplasmic sperm injection (ICSI) attempts. The study emphasizes the need for further research to refine diagnostic approaches and deepen the understanding of factors influencing sperm retrieval in NOA patients, ultimately enhancing their prospects of biological parenthood.
Implicit Hedging and Liquidity Costs of Structured Products
Authors: Avdiu Kujtim , Unger Stephan
Published: September 2023

This article analyzes the implicit hedging and liquidity costs of structured equity products offered by various financial institutions. We replicate several payoffs of structured products, compare the calculated fair values based on the Heston model as well as geometric Brownian motion, using various optimization techniques, and compare their fair values with the historic prices traded in the market. We find that implicit hedging costs range between 0.9% and 2.9% markup on the fair value, where we find the underlying market volatility to be the relevant driver of this range for complex structures, while market liquidity can be extracted as the only driver of markups for simple structures with no hedging requirements.
Is Controlled Drainage of Agricultural Land a Common Used Practice?—A Bibliographic Analysis
Authors: Kęsicka Barbara , Stasik Rafał , Kozłowski Michał , Choryński Adam
Published: September 2023

Controlled drainage (CD) is one of the basic techniques used to manage groundwater levels. Farmers can optimize water levels for crop growth at different stages of the growing season. Proper drainage water management can reduce the risk of soil erosion and surface water pollution. By controlling drainage, sediment and nutrient runoff can be minimized, leading to improved water quality in nearby streams and rivers. A mixed methods approach was used, which was based on the bibliometric analysis and content analysis of 462 articles using the bibliometrix R package and VOSviewer software. The article aimed to analyze the Author Keywords and KeyWords Plus to indicate the resulting clusters of complex interdependence that emerge from the main research areas. Continuous research continues to improve drainage techniques and systems to optimize agricultural water use. The results indicated the importance of researching the feasibility of CD for agriculture. The innovation of this study is that it points out the relevance of taking up the possibility of changing the use of unilateral subsurface drainage systems with another method of controlling drainage outflows as a current global challenge, contributing to filling this gap in the literature.
Study on Influencing Factors and Planning Strategies of Population Spatial Distribution in Urban Fringe Areas from the Perspective of Built Environment—The Case of Wuhan, China
Authors: Long Yan , Lu Zhengyuan , Hu Siyu , Luo Shiqi , Liu Xi , Shao Jingmei , Zheng Yuqiao , Liu Xuejun
Published: September 2023

Rationally relieving the population of urban centers in large cities, such as megacities and supercities, is one of the current goals of population development in China. The fringe area of a large city is a potential area to undertake the population of the central area. Studying the relationship between the population and the built environment in this area can help urban planners formulate targeted construction strategies to attract the population of the city center to move to the fringe areas. This paper takes the fringe areas of Wuhan in 2010 and 2020 as its specific research object and puts forward the “5D” index system of built environments that affects the spatial distribution of population based on population data and built environment data. The OLS model is used to screen the influencing factors. This paper analyzes the correlation between population and built environment using a multi-scale geographic weighted regression model as well. According to the results of the regression analysis combined with the development and construction of the fringe areas of remote urban areas in Wuhan over the past 20 years, some suggestions are put forward for the planning and construction of remote urban areas. The results show that the “5D” index system of the built environment covers the influencing factors of the spatial distribution of the population. MGWR reveals the correlation between the influencing factors and the spatial distribution of population in the marginal areas on the global scale and the local scale, respectively, which provides a clear direction for the development of planning and construction to improve the attractiveness of the non-central areas to the population.
Ocimum sanctum Alters the Lipid Landscape of the Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in a Mouse Model
Authors: Yadav Inderjeet , Sharma Nupur , Velayudhan Rema , Fatima Zeeshan , Maras Jaswinder Singh
Published: September 2023

Stroke-like injuries in the brain result in not only cell death at the site of the injury but also other detrimental structural and molecular changes in regions around the stroke. A stroke-induced alteration in the lipid profile interferes with neuronal functions such as neurotransmission. Preventing these unfavorable changes is important for recovery. Ocimum sanctum (Tulsi extract) is known to have anti-inflammatory and neuroprotective properties. It is possible that Tulsi imparts a neuroprotective effect through the lipophilic transfer of active ingredients into the brain. Hence, we examined alterations in the lipid profile in the cerebral cortex as well as the plasma of mice with a photothrombotic-ischemic-stroke-like injury following the administration of a Tulsi extract. It is also possible that the lipids present in the Tulsi extract could contribute to the lipophilic transfer of active ingredients into the brain. Therefore, to identify the major lipid species in the Tulsi extract, we performed metabolomic and untargeted lipidomic analyses on the Tulsi extract. The presence of 39 molecular lipid species was detected in the Tulsi extract. We then examined the effect of a treatment using the Tulsi extract on the untargeted lipidomic profile of the brain and plasma following photothrombotic ischemic stroke in a mouse model. Mice of the C57Bl/6j strain, aged 2–3 months, were randomly divided into four groups: (i) Sham, (ii) Lesion, (iii) Lesion plus Tulsi, and (iv) Lesion plus Ibuprofen. The cerebral cortex of the lesioned hemisphere of the brain and plasma samples were collected for untargeted lipidomic profiling using a Q-Exactive Mass Spectrometer. Our results documented significant alterations in major lipid groups, including PE, PC, neutral glycerolipids, PS, and P-glycerol, in the brain and plasma samples from the photothrombotic stroke mice following their treatment with Tulsi. Upon further comparison between the different study groups of mice, levels of MGDG (36:4), which may assist in recovery, were found to be increased in the brain cortexes of the mice treated with Tulsi when compared to the other groups (p < 0.05). Lipid species such as PS, PE, LPG, and PI were commonly altered in the Sham and Lesion plus Tulsi groups. The brain samples from the Sham group were specifically enriched in many species of glycerol lipids and had reduced PE species, while their plasma samples showed altered PE and PS species when compared to the Lesion group. LPC (16:1) was found in the Tulsi extract and was significantly increased in the brains of the PTL-plus-Tulsi-treated group. Our results suggest that the neuroprotective effect of Tulsi on cerebral ischemia may be partially associated with its ability to regulate brain and plasma lipids, and these results may help provide critical insights into therapeutic options for cerebral ischemia or brain lesions.
Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance
Authors: Kalantari Forough , Mohseninia Nasibeh , Wetsch Andreas , Harsini Sara , Hehenwarter Lukas , Schweighofer-Zwink Gregor , Zamani-Siahkali Nazanin , Rendl Gundula , Beheshti Mohsen , Pirich Christian
Published: September 2023

Background: Myocardial perfusion imaging (MPI) plays a crucial role in diagnosing coronary artery disease (CAD), with single-photon emission computed tomography (SPECT) being a widely accepted method. The accuracy of MPI relies on image quality and the expertise of physicians. While CZT-SPECT cameras offer advantages, they can be susceptible to attenuation artifacts. Therefore, our objective was to evaluate the diagnostic accuracy of CZT-SPECT and SPECT/CT in a clinical setting. Method: We conducted a prospective single-center study involving patients with known or suspected stable ischemic heart disease who underwent SPECT-MPI using CZT-SPECT and SPECT/CT scanners, and the latter was equipped with cardiofocal collimation. Experienced physicians performed analysis and reporting based on automated quantification and visual image interpretation. Results: A total of 77 patients (32 women (41.6%) and 45 men (58.4%) with an average age of 71.9 ± 8.9 years) were included. The agreement between readers regarding the final conclusion based on imaging reporting using both devices was very high (Kappa 0.87–0.93). Per-vessel analysis revealed a trend suggesting that CZT-SPECT was superior to conventional SPECT/CT in terms of sensitivity, positive predictive value (PPV), negative predictive value (NPV), and accuracy, although the difference did not reach statistical significance. Conclusion: Our study demonstrated that CZT-SPECT imaging offers comparable diagnostic accuracy, improved patient comfort, and eliminates CT-induced radiation compared to SPECT/CT. These findings suggest that cardiac CZT-SPECT imaging has the potential to become a valuable imaging modality in clinical practice.
Exploring Patient Beliefs and Medication Adherence in the Mediterranean Context: A Cross-Sectional Study in Patients with Cardiovascular Diseases and Cardiometabolic Disorders in Greece—The IACT-Study
Authors: Belitsi Vasiliki , Tsiampalis Thomas , Kouvari Matina , Kalantzi Vasiliki , Androutsos Odysseas , Bonoti Fotini , Panagiotakos Demosthenes , Kosti Rena
Published: September 2023

Background: Evidence has shown that poor adherence to vascular medications contributes to a considerable proportion of all cardiovascular disease (CVD) events and mortality. The aim of the present work was to examine patients’ beliefs/views that affect their level of adherence to the assigned medical treatment in the context of a multi-center study in Greece. Methods: Between July 2022 and April 2023, 1988 patients (1180 females) with established cardiovascular disease or relevant cardiometabolic disorders were chosen from seven medical centers in Greece. The 4-item Morisky Medication Adherence Questionnaire gauged medication adherence and investigated patients’ beliefs/views regarding treatment. Results: Among participants, 51.2% showed perfect medication adherence, contrasting with 48.8% displaying poor adherence. Patients with negative medication beliefs were around three times more likely to be non-adherent (OR = 2.73; 95% CI = 2.28–3.28). Non-adherers held concerns about drug efficacy (OR = 2.34; 95% CI = 1.10–4.97) and favored alternative therapies (OR = 2.25; 95% CI = 1.75–2.91). Conclusion: The findings highlight the significance of addressing patient beliefs/views to improve medication adherence. The distinct Mediterranean context, influenced by cultural, socioeconomic, and clinical factors, emphasizes the need for tailored interventions. This underscores the call for contextually sensitive strategies to boost medication adherence and improve health outcomes in this unique region.
AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study
Authors: Alshuweishi Yazeed , Alfaifi Mohammed , Almoghrabi Yousef , Alfhili Mohammad A.
Published: September 2023

Background: Hyperglycemia is a common symptom of numerous conditions, most notably diabetes mellitus and Cushing’s syndrome, and the liver plays a pivotal role in the regulation of glucose metabolism. The AST–platelet ratio index (AST APRI score) and ALT–platelet ratio index (ALT APRI score) are novel parameters whose association with circulating glucose levels remains poorly studied. Methods: Laboratory data of 14,177 subjects were retrospectively analyzed for the association between AST and ALT APRI scores and fasting blood glucose (FBG) using the Mann–Whitney U and Kruskal–Wallis tests, Spearman’s rank correlation coefficient, prevalence and odds ratio (OR) and ROC curve analysis. Results: AST and ALT APRI scores showed progressive increases with FBG, and the mean FBG was significantly higher in subjects with high AST (104.9 ± 0.33 to 120.8 ± 3.27, p < 0.0001) and ALT (104.7 ± 0.34 to 111.6 ± 1.30, p < 0.0001) APRI scores. However, the AST APRI score but not the ALT APRI score was affected by age and gender. Notably, both elevated AST and ALT APRI scores were more prevalent in hyperglycemic subjects irrespective of gender and were associated with FBG, albeit through mediator variables. Increased AST (OR = 2.55, 95% CI: 1.46–2.06, p < 0.0001) and ALT (OR = 1.73, 95% CI: 1.46–2.06, p < 0.0001) APRI scores carried a significantly higher risk for hyperglycemia. Importantly, the ALT APRI score was superior to that of the AST APRI score in distinguishing hyperglycemic subjects. Conclusions: The AST and ALT APRI scores are inexpensive, novel markers of FBG and may serve as supportive evidence in the diagnosis and management of hyperglycemic conditions.
Coagulation Dysfunctions in Non-Alcoholic Fatty Liver Disease—Oxidative Stress and Inflammation Relevance
Authors: Robea Madalina Andreea , Balmus Ioana-Miruna , Girleanu Irina , Huiban Laura , Muzica Cristina , Ciobica Alin , Stanciu Carol , Cimpoesu Carmen Diana , Trifan Anca
Published: September 2023

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. Its incidence is progressively rising and it is possibly becoming a worldwide epidemic. NAFLD encompasses a spectrum of diseases accounting for the chronic accumulation of fat within the hepatocytes due to various causes, excluding excessive alcohol consumption. In this study, we aimed to focus on finding evidence regarding the implications of oxidative stress and inflammatory processes that form the multifaceted pathophysiological tableau in relation to thrombotic events that co-occur in NAFLD and associated chronic liver diseases. Recent evidence on the pathophysiology of NAFLD suggests that a complex pattern of multidirectional components, such as prooxidative, proinflammatory, and prothrombotic components, better explains the multiple factors that promote the mechanisms underlying the fatty acid excess and subsequent processes. As there is extensive evidence on the multi-component nature of NAFLD pathophysiology, further studies could address the complex interactions that underlie the development and progression of the disease. Therefore, this study aimed to describe possible pathophysiological mechanisms connecting the molecular impairments with the various clinical manifestations, focusing especially on the interactions among oxidative stress, inflammation, and coagulation dysfunctions. Thus, we described the possible bidirectional modulation among coagulation homeostasis, oxidative stress, and inflammation that occurs in the various stages of NAFLD.
Ultrasound Sonosensitizers for Tumor Sonodynamic Therapy and Imaging: A New Direction with Clinical Translation
Authors: Liang Yunlong , Zhang Mingzhen , Zhang Yujie , Zhang Mingxin
Published: September 2023

With the rapid development of sonodynamic therapy (SDT), sonosensitizers have evolved from traditional treatments to comprehensive diagnostics and therapies. Sonosensitizers play a crucial role in the integration of ultrasound imaging (USI), X-ray computed tomography (CT), and magnetic resonance imaging (MRI) diagnostics while also playing a therapeutic role. This review was based on recent articles on multifunctional sonosensitizers that were used in SDT for the treatment of cancer and have the potential for clinical USI, CT, and MRI applications. Next, some of the shortcomings of the clinical examination and the results of sonosensitizers in animal imaging were described. Finally, this paper attempted to inform the future development of sonosensitizers in the field of integrative diagnostics and therapeutics and to point out current problems and prospects for their application.
Supramolecular Motifs in the Crystal Structures of Triethylbenzene Derivatives Bearing Pyridinium Subunits in Combination with Pyrimidinyl or Pyridinyl Groups
Authors: Weiße Andrea , Seichter Wilhelm , Mazik Monika
Published: September 2023

A series of mono- and dicationic 1,3,5-trisubstituted 2,4,6-triethylbenzenes containing pyridinium groups in combination with aminopyrimidine-/aminopyridine-based recognition units were synthesized and crystallographically studied. The combination of neutral and ionic building blocks represents a promising strategy for the development of effective and selective artificial receptors for anionic substrates. In the crystalline state, the investigated compounds show a tendency to bind the counterion PF6− in the cavity formed by the three functionalized side-arms. The intermolecular interactions with the PF6− ion comprise N-H∙∙∙F and C-H∙∙∙F bonds. Detailed analysis of various supramolecular motifs, including interactions with solvent molecules, provides deeper insights into the processes of molecular recognition. The information obtained is useful in the development of new receptor molecules for anions and in the selection of the most appropriate counterion.