bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Improved Risk-Stratification Scheme for Mismatch-Repair Proficient Stage II Colorectal Cancers Using the Digital Pathology Biomarker QuantCRC
Authors: Wu Christina , Pai Reetesh K. , Kosiorek Heidi , Banerjee Imon , Pfeiffer Ashlyn , Hagen Catherine E. , Hartley Christopher P. , Graham Rondell P. , Sonbol Mohamad B. , Bekaii-Saab Tanios , Xie Hao , Sinicrope Frank A. , Patel Bhavik , Westerling-Bui Thomas , Shivji Sameer , Conner James , Swallow Carol , Savage Paul , Cyr David P. , Kirsch Richard , Pai Rish K.
Published: May 2024

AbstractPurpose:
There is a need to improve current risk stratification of stage II colorectal cancer to better inform risk of recurrence and guide adjuvant chemotherapy. We sought to examine whether integration of QuantCRC, a digital pathology biomarker utilizing hematoxylin and eosin–stained slides, provides improved risk stratification over current American Society of Clinical Oncology (ASCO) guidelines.
Experimental Design:
ASCO and QuantCRC-integrated schemes were applied to a cohort of 398 mismatch-repair proficient (MMRP) stage II colorectal cancers from three large academic medical centers. The ASCO stage II scheme was taken from recent guidelines. The QuantCRC-integrated scheme utilized pT3 versus pT4 and a QuantCRC-derived risk classification. Evaluation of recurrence-free survival (RFS) according to these risk schemes was compared using the log-rank test and HR.
Results:
Integration of QuantCRC provides improved risk stratification compared with the ASCO scheme for stage II MMRP colorectal cancers. The QuantCRC-integrated scheme placed more stage II tumors in the low-risk group compared with the ASCO scheme (62.5% vs. 42.2%) without compromising excellent 3-year RFS. The QuantCRC-integrated scheme provided larger HR for both intermediate-risk (2.27; 95% CI, 1.32–3.91; P = 0.003) and high-risk (3.27; 95% CI, 1.42–7.55; P = 0.006) groups compared with ASCO intermediate-risk (1.58; 95% CI, 0.87–2.87; P = 0.1) and high-risk (2.24; 95% CI, 1.09–4.62; P = 0.03) groups. The QuantCRC-integrated risk groups remained prognostic in the subgroup of patients that did not receive any adjuvant chemotherapy.
Conclusions:
Incorporation of QuantCRC into risk stratification provides a powerful predictor of RFS that has potential to guide subsequent treatment and surveillance for stage II MMRP colorectal cancers.
Supplementary Figure S6 from Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Authors: Dunbar Andrew J. , Bowman Robert L. , Park Young C. , O'Connor Kavi , Izzo Franco , Myers Robert M. , Karzai Abdul , Zaroogian Zachary , Kim Won Jun , Fernández-Maestre Inés , Waarts Michael R. , Nazir Abbas , Xiao Wenbin , Codilupi Tamara , Brodsky Max , Farina Mirko , Cai Louise , Cai Sheng F. , Wang Benjamin , An Wenbin , Yang Julie L. , Mowla Shoron , Eisman Shira E. , Hanasoge Somasundara Amritha Varshini , Glass Jacob L. , Mishra Tanmay , Houston Remie , Guzzardi Emily , Martinez Benitez Anthony R. , Viny Aaron D. , Koche Richard P. , Meyer Sara C. , Landau Dan A. , Levine Ross L.
Published: May 2024

Acute phenotypic and transcriptional changes following Jak2V617F reversion
Supplementary Figure S1 from Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Authors: Dunbar Andrew J. , Bowman Robert L. , Park Young C. , O'Connor Kavi , Izzo Franco , Myers Robert M. , Karzai Abdul , Zaroogian Zachary , Kim Won Jun , Fernández-Maestre Inés , Waarts Michael R. , Nazir Abbas , Xiao Wenbin , Codilupi Tamara , Brodsky Max , Farina Mirko , Cai Louise , Cai Sheng F. , Wang Benjamin , An Wenbin , Yang Julie L. , Mowla Shoron , Eisman Shira E. , Hanasoge Somasundara Amritha Varshini , Glass Jacob L. , Mishra Tanmay , Houston Remie , Guzzardi Emily , Martinez Benitez Anthony R. , Viny Aaron D. , Koche Richard P. , Meyer Sara C. , Landau Dan A. , Levine Ross L.
Published: May 2024

Phenotypic characterization and validation of Jak2RL activation in vivo
Figure S9 from Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer
Authors: An Minae , Mehta Arnav , Min Byung Hoon , Heo You Jeong , Wright Samuel J. , Parikh Milan , Bi Lynn , Lee Hyuk , Kim Tae Jun , Lee Song-Yi , Moon Jeonghyeon , Park Ryan J. , Strickland Matthew R. , Park Woong-Yang , Kang Won Ki , Kim Kyoung-Mee , Kim Seung Tae , Klempner Samuel J. , Lee Jeeyun
Published: May 2024

Figure S9. (A) Cell type proportions from scSeq shown by individual patient split
by individual high-level cell types across timepoints, color coded by fast vs slow
progression status. (B) Cell type proportions from scSeq data by timepoint and
fast vs slow progressor status including only GS and CIN patients.
Supplementary Table S2 from Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases
Authors: Horie Sara , Saito Yuki , Kogure Yasunori , Mizuno Kota , Ito Yuta , Tabata Mariko , Kanai Takanori , Murakami Koichi , Koya Junji , Kataoka Keisuke
Published: May 2024

Targeted genes in each gene panel
Supplementary Figure S9 from Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs
Authors: Pal Choudhuri Shreoshi , Girard Luc , Lim Jun Yi Stanley , Wise Jillian F. , Freitas Braeden , Yang Di , Wong Edmond , Hamilton Seth , Chien Victor D. , Kim Yoon Jung , Gilbreath Collin , Zhong Jun , Phat Sarah , Myers David T. , Christensen Camilla L. , Mazloom-Farsibaf Hanieh , Stanzione Marcello , Wong Kwok-Kin , Hung Yin P. , Farago Anna F. , Meador Catherine B. , Dyson Nicholas J. , Lawrence Michael S. , Wu Sihan , Drapkin Benjamin J.
Published: May 2024

Reconstruction of ecDNAs containing MYC paralogs and MYCL FISH in MGH1501-1A metaphase chromosomes.
Supplementary Figure S8 from Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs
Authors: Pal Choudhuri Shreoshi , Girard Luc , Lim Jun Yi Stanley , Wise Jillian F. , Freitas Braeden , Yang Di , Wong Edmond , Hamilton Seth , Chien Victor D. , Kim Yoon Jung , Gilbreath Collin , Zhong Jun , Phat Sarah , Myers David T. , Christensen Camilla L. , Mazloom-Farsibaf Hanieh , Stanzione Marcello , Wong Kwok-Kin , Hung Yin P. , Farago Anna F. , Meador Catherine B. , Dyson Nicholas J. , Lawrence Michael S. , Wu Sihan , Drapkin Benjamin J.
Published: May 2024

Comparison of chemotherapy regimen delta-AUC and comparison of average delta-AUC by PDX source.
Supplementary Figure S9 from Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
Authors: Rosano Dalia , Sofyali Emre , Dhiman Heena , Ghirardi Chiara , Ivanoiu Diana , Heide Timon , Vingiani Andrea , Bertolotti Alessia , Pruneri Giancarlo , Canale Eleonora , Dewhurst Hannah F. , Saha Debjani , Slaven Neil , Barozzi Iros , Li Tong , Zemlyanskiy Grigory , Phillips Henry , James Chela , Győrffy Balázs , Lynn Claire , Cresswell George D. , Rehman Farah , Noberini Roberta , Bonaldi Tiziana , Sottoriva Andrea , Magnani Luca
Published: May 2024

Correlation between barcode composition in Traditiom samples
Supplementary Figure S7 from Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
Authors: Rosano Dalia , Sofyali Emre , Dhiman Heena , Ghirardi Chiara , Ivanoiu Diana , Heide Timon , Vingiani Andrea , Bertolotti Alessia , Pruneri Giancarlo , Canale Eleonora , Dewhurst Hannah F. , Saha Debjani , Slaven Neil , Barozzi Iros , Li Tong , Zemlyanskiy Grigory , Phillips Henry , James Chela , Győrffy Balázs , Lynn Claire , Cresswell George D. , Rehman Farah , Noberini Roberta , Bonaldi Tiziana , Sottoriva Andrea , Magnani Luca
Published: May 2024

Differential expression profiling of tumour biopsies from spatially resolved CK+ segments of patients 1-3 (rare cohort treated with long-term ET until progression)
Supplementary Figure S5 from Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs
Authors: Pal Choudhuri Shreoshi , Girard Luc , Lim Jun Yi Stanley , Wise Jillian F. , Freitas Braeden , Yang Di , Wong Edmond , Hamilton Seth , Chien Victor D. , Kim Yoon Jung , Gilbreath Collin , Zhong Jun , Phat Sarah , Myers David T. , Christensen Camilla L. , Mazloom-Farsibaf Hanieh , Stanzione Marcello , Wong Kwok-Kin , Hung Yin P. , Farago Anna F. , Meador Catherine B. , Dyson Nicholas J. , Lawrence Michael S. , Wu Sihan , Drapkin Benjamin J.
Published: May 2024

Method to compare ecMYC level with resistance to drug-induced DNA damage.
Supplementary Figure S2 from Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
Authors: Rosano Dalia , Sofyali Emre , Dhiman Heena , Ghirardi Chiara , Ivanoiu Diana , Heide Timon , Vingiani Andrea , Bertolotti Alessia , Pruneri Giancarlo , Canale Eleonora , Dewhurst Hannah F. , Saha Debjani , Slaven Neil , Barozzi Iros , Li Tong , Zemlyanskiy Grigory , Phillips Henry , James Chela , Győrffy Balázs , Lynn Claire , Cresswell George D. , Rehman Farah , Noberini Roberta , Bonaldi Tiziana , Sottoriva Andrea , Magnani Luca
Published: May 2024

Clinical history of patient 1 (rare cohort treated with long-term ET until progression)
Supplementary Figure S15 from Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
Authors: Rosano Dalia , Sofyali Emre , Dhiman Heena , Ghirardi Chiara , Ivanoiu Diana , Heide Timon , Vingiani Andrea , Bertolotti Alessia , Pruneri Giancarlo , Canale Eleonora , Dewhurst Hannah F. , Saha Debjani , Slaven Neil , Barozzi Iros , Li Tong , Zemlyanskiy Grigory , Phillips Henry , James Chela , Győrffy Balázs , Lynn Claire , Cresswell George D. , Rehman Farah , Noberini Roberta , Bonaldi Tiziana , Sottoriva Andrea , Magnani Luca
Published: May 2024

Genomic analysis of breast cancer drivers and non-coding alterations in Traditiom samples
Table S18 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations
Authors: Bashi Azadeh C. , Coker Elizabeth A. , Bulusu Krishna C. , Jaaks Patricia , Crafter Claire , Lightfoot Howard , Milo Marta , McCarten Katrina , Jenkins David F. , van der Meer Dieudonne , Lynch James T. , Barthorpe Syd , Andersen Courtney L. , Barry Simon T. , Beck Alexandra , Cidado Justin , Gordon Jacob A. , Hall Caitlin , Hall James , Mali Iman , Mironenko Tatiana , Mongeon Kevin , Morris James , Richardson Laura , Smith Paul D. , Tavana Omid , Tolley Charlotte , Thomas Frances , Willis Brandon S. , Yang Wanjuan , O'Connor Mark J. , McDermott Ultan , Critchlow Susan E. , Drew Lisa , Fawell Stephen E. , Mettetal Jerome T. , Garnett Mathew J.
Published: May 2024

Supplementary Table 18 shows drug response data for single agents and combination treatments
Supplementary Table S2 from Cancer Mutations Converge on a Collection of Protein Assemblies to Predict Resistance to Replication Stress
Authors: Zhao Xiaoyu , Singhal Akshat , Park Sungjoon , Kong JungHo , Bachelder Robin , Ideker Trey
Published: May 2024

Table S2 Odds ratio for 45 drug response predictions with multi-drug model.xlsx
Data from Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer
Authors: An Minae , Mehta Arnav , Min Byung Hoon , Heo You Jeong , Wright Samuel J. , Parikh Milan , Bi Lynn , Lee Hyuk , Kim Tae Jun , Lee Song-Yi , Moon Jeonghyeon , Park Ryan J. , Strickland Matthew R. , Park Woong-Yang , Kang Won Ki , Kim Kyoung-Mee , Kim Seung Tae , Klempner Samuel J. , Lee Jeeyun
Published: May 2024

Abstract
Adding anti–programmed cell death protein 1 (anti–PD-1) to 5-fluorouracil (5-FU)/platinum improves survival in some advanced gastroesophageal adenocarcinomas (GEA). To understand the effects of chemotherapy and immunotherapy, we conducted a phase II first-line trial (n = 47) sequentially adding pembrolizumab to 5-FU/platinum in advanced GEA. Using serial biopsy of the primary tumor at baseline, after one cycle of 5-FU/platinum, and after the addition of pembrolizumab, we transcriptionally profiled 358,067 single cells to identify evolving multicellular tumor microenvironment (TME) networks. Chemotherapy induced early on-treatment multicellular hubs with tumor-reactive T-cell and M1-like macrophage interactions in slow progressors. Faster progression featured increased MUC5A and MSLN containing treatment resistance programs in tumor cells and M2-like macrophages with immunosuppressive stromal interactions. After pembrolizumab, we observed increased CD8 T-cell infiltration and development of an immunity hub involving tumor-reactive CXCL13 T-cell program and epithelial interferon-stimulated gene programs. Strategies to drive increases in antitumor immune hub formation could expand the portion of patients benefiting from anti–PD-1 approaches.
Significance:
The benefit of 5-FU/platinum with anti–PD-1 in first-line advanced gastric cancer is limited to patient subgroups. Using a trial with sequential anti–PD-1, we show coordinated induction of multicellular TME hubs informs the ability of anti–PD-1 to potentiate T cell–driven responses. Differential TME hub development highlights features that underlie clinical outcomes.

This article is featured in Selected Articles from This Issue, p. 695
Data from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations
Authors: Bashi Azadeh C. , Coker Elizabeth A. , Bulusu Krishna C. , Jaaks Patricia , Crafter Claire , Lightfoot Howard , Milo Marta , McCarten Katrina , Jenkins David F. , van der Meer Dieudonne , Lynch James T. , Barthorpe Syd , Andersen Courtney L. , Barry Simon T. , Beck Alexandra , Cidado Justin , Gordon Jacob A. , Hall Caitlin , Hall James , Mali Iman , Mironenko Tatiana , Mongeon Kevin , Morris James , Richardson Laura , Smith Paul D. , Tavana Omid , Tolley Charlotte , Thomas Frances , Willis Brandon S. , Yang Wanjuan , O'Connor Mark J. , McDermott Ultan , Critchlow Susan E. , Drew Lisa , Fawell Stephen E. , Mettetal Jerome T. , Garnett Mathew J.
Published: May 2024

Abstract
Oncology drug combinations can improve therapeutic responses and increase treatment options for patients. The number of possible combinations is vast and responses can be context-specific. Systematic screens can identify clinically relevant, actionable combinations in defined patient subtypes. We present data for 109 anticancer drug combinations from AstraZeneca's oncology small molecule portfolio screened in 755 pan-cancer cell lines. Combinations were screened in a 7 × 7 concentration matrix, with more than 4 million measurements of sensitivity, producing an exceptionally data-rich resource. We implement a new approach using combination Emax (viability effect) and highest single agent (HSA) to assess combination benefit. We designed a clinical translatability workflow to identify combinations with clearly defined patient populations, rationale for tolerability based on tumor type and combination-specific “emergent” biomarkers, and exposures relevant to clinical doses. We describe three actionable combinations in defined cancer types, confirmed in vitro and in vivo, with a focus on hematologic cancers and apoptotic targets.
Significance:
We present the largest cancer drug combination screen published to date with 7 × 7 concentration response matrices for 109 combinations in more than 750 cell lines, complemented by multi-omics predictors of response and identification of “emergent” combination biomarkers. We prioritize hits to optimize clinical translatability, and experimentally validate novel combination hypotheses.

This article is featured in Selected Articles from This Issue, p. 695
Supplementary Figure 3 from Spatial Mapping of Hematopoietic Clones in Human Bone Marrow
Authors: Young Andrew L. , Davis Hannah C. , Cox Maggie J. , Parsons Tyler M. , Burkart Samantha C. , Bender Diane E. , Sun Lulu , Oh Stephen T. , Challen Grant A.
Published: May 2024

Supplementary Figure 3. Umap of bone marrow fragment clustering by somatic mutation VAFs.
Figure S4 from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Authors: Olesinski Elyse A. , Bhatia Karanpreet Singh , Wang Chuqi , Pioso Marissa S. , Lin Xiao Xian , Mamdouh Ahmed M. , Ng Shu Xuan , Sandhu Vedant , Jasdanwala Shaista Shabbir , Yilma Binyam , Bohl Stephan , Ryan Jeremy A. , Malani Disha , Luskin Marlise R. , Kallioniemi Olli , Porkka Kimmo , Adamia Sophia , Chng Wee Joo , Osato Motomi , Weinstock David M. , Garcia Jacqueline S. , Letai Anthony , Bhatt Shruti
Published: May 2024

Supplemental Figure 4 shows differential expression of BCL-2 family related genes and proteins in drug-resistant AML PDX models.
Acidentes neuroparalíticos das vacinações anti-rábicas
Authors: Assis José Lamartine de
Published: May 2024

Após ressaltar a importância do tema, a freqüência da neurotuberculoseno País e as atuais possibilidades de tratamento, o autor sintetiza os principais tópicos referentes à etiopatogenia e à anatomia patológica.Descreve, a seguir, as características clínicas da neurotuberculose, considerando três formas principais: meningencefalite subaguda difusa, forma hipertensiva e forma tumoral. O diagnóstico é discutido sob os aspectos clínico, laboratorial e diferencial, ressaltando o valor do exame do líquido cefalorraquidiano no diagnóstico precoce da meningencefalite; referência especial é feita à progressiva baixa dos cloretos, como elemento dos mais sugestivos para o diagnóstico.Finalmente, o autor faz considerações sobre o tratamento, dividindo oassunto em duas partes: tratamento médico e tratamento cirúrgico. Noprimeiro, estuda as drogas standard, as de reserva e as adjuvantes; no segundo, aponta as técnicas mais usadas, destacando as derivações extracranianas.
As manifestações neurológicas da lepra
Authors: Julião Oswaldo Freitas
Published: May 2024

Os casos de lepra nos quais há exclusivamente acometimento neurológicosuscitam, não raro, problemas embaraçosos de diagnóstico diferencial, não só porque não se acompanham das lesões cutâneas típicas mas ainda porque o exame bacterioscópico é habitualmente negativo; mesmo o exame histopatológico poderá ser inconclusivo, por evidenciar, muitas vezes, alterações incaracterísticas. Neurites isoladas do nervo ulnar ou do peroneal, áreas de anestesia conseqüentes a lesões neurorramusculares, perturbações úlcero-mutilantes das extremidades exemplificam algumas das condições clínicas capazes de originar problemas dessa espécie.O autor procura, nesta exposição, realçar o valor diagnóstico dos conhecimentos de ordem puramente neurológica para a elucidação de tais casos, pois apenas eles permitirão, na maioria das vezes, dirimir as dúvidas existentes.
Propedêutica urológica
Authors: Srougi Miguel , Lemos Gustavo Caserta , Góes Gilberto Menezes de
Published: May 2024

Os autores apresentam suscintamente os principais métodos de propedêutica urológica, abordados em 4 tópicos: métodos radiológicos, métodos endoscópicos, métodos radioisotópicos e métodos manométricos. São abordados os princípios sobre os quais se apoiam estes exames, o modo de realização, indicações sobre a utilização dos métodos e alguns exemplos clínicos.
As soluções hipertônicas no tratamento do choque hipovolêmico
Authors: Younes Riad Naim
Published: May 2024

O autor apresenta uma revisão bibliográfica dos trabalhos desenvolvidos na área de tratamento do choque hemorrágico utilizando soluções asanguíneas e particularmente as soluções hipertônicas, além de relatar alguns resultados prévios de pesquisas em desenvolvimento no departamento de fisiologia do I.C.B. da USP.
Cordomas: estudo anátomo-clínico de 8 casos
Authors: Aguiar Paulo Henrique Pires de , Aoki Valéria , Costa Vital Paulino , Osório Carlos Alberto Martinez , Tsanaclis Ana Maria
Published: May 2024

Foram estudados e revistos 8 casos de pacientes com cordomas, diagnosticados no período compreendido entre janeiro de 1953 e dezembro de 1985, sendo 6 de localização intracraniana, 1 de origem sacrococcígea provável e 1 cervical. Analisaram-se dados clínicos de exame físico e neurológico, bem como métodos diagnósticos. Ressaltam-se a raridade do tumor, o predomínio deste em pacientes do sexo feminino e em território intracraniano (estes dois últimos dados conflitantes com os da literatura) e seu acometimento na faixa etária de 30 anos (idade média de 31 anos). Os cordomas apresentam sintomatologia diversa, dependente de sua localização; apesar de possuirem caracteres histológicos benignos, a sobrevida em 5 anos é baixa, por causa do seu comportamento infiltrativo, da ocorrência de recidivas após tratamento radioterápico e/ou cirúrgico e de eventuais metástases.
Do direito à literatura ao direito a narrar-se
Authors: Barros Leonardo Canuto de
Published: May 2024

Sem resumo.
Entrevista com Ruy Fausto
Authors: Fausto Ruy , Carrasco Alexandre
Published: May 2024

Entrevista concedida em julho de 2007 a Alexandre Carrrasco
Active Arrhythmia Pattern: A Novel Predictor of ICD Shocks—A Subanalysis From the PARTITA Study
Authors: Radinovic Andrea , Giacopelli Daniele , Bisceglia Caterina , Paglino Gabriele , Gargaro Alessio , Della Bella Paolo
Published: May 2024

BACKGROUND:

In the PARTITA trial (Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients With an Implantable Cardioverter Defibrillator?), antitachycardia pacing (ATP) predicted the occurrence of implantable cardioverter defibrillator (ICD) shocks. Catheter ablation of ventricular tachycardia after the first shock reduced the risk of death or worsening heart failure. A threshold of ATPs that might warrant an ablation procedure before ICD shocks is unknown. Our aim was to identify a threshold of ATPs and clinical features that predict the occurrence of shocks and cardiovascular events.

METHODS:

We analyzed data from 517 patients in phase A of the PARTITA study. We used classification and regression tree analysis to develop and test a risk stratification model based on arrhythmia patterns and clinical data to predict ICD shocks. Secondary end points were worsening heart failure and cardiovascular hospitalization.

RESULTS:

Classification and regression tree classified patients into 6 leaves by increasing shock probability. Patients treated with ≥5 ATPs in 6 months (active arrhythmia pattern) had the highest risk of ICD shocks (93% and 86%, training and testing samples, respectively). Patients without ATPs had the lowest (1% and 2%). Other predictors included left ventricle ejection fraction<35%, age of <60 years, and obesity. Survival analysis revealed a higher risk of worsening heart failure (hazard ratio, 5.45 [95% CI, 1.62–18.4];
P
=0.006) and cardiovascular hospitalization (hazard ratio, 7.29 [95% CI, 3.66–14.5];
P
<0.001) for patients with an active arrhythmia pattern compared with those without ATPs.

CONCLUSIONS:

Patients with an active arrhythmia pattern (≥5 ATPs in 6 months) are associated with an increased risk of ICD shocks, as well as heart failure hospitalization and cardiovascular hospitalization. These data suggest that additional treatments may be helpful to this high-risk group as a preventive strategy to reduce the incidence of major events. Further prospective randomized trials are needed to confirm the benefits of early ventricular tachycardia ablation in this setting.
Four criconematid species from avocado orchards in Florida, USA
Authors: Singh Phougeishangbam Rolish , Gitonga Denis , Hajihassani Abolfazl
Published: May 2024

Four criconematid populations were uncovered in three avocado orchards in Homestead region, Miami-Dade County, Florida, USA, with three of them in relatively high densities. Two of the populations were identified as Criconema mutabile (Taylor, 1936) Raski & Luc, 1985 and Mesocriconema basili (Jairajpuri, 1964) Loof & De Grisse, 1989, whereas the other two populations were identified as Criconemoides sp. and Ogma sp. The identification of the nematodes was based on morphological analysis and C. mutabile was also confirmed based on the 28S rRNA gene. The molecular data of M. basili (18S and 28S rRNA genes) are presented for the first time and phylogenetic trees based on the genes are provided illustrating the relationships of M. basili with other criconematid species. This study further reports the presence of C. mutabile and M. basili for the first time in Florida, USA, and the association of the latter species with avocado rhizosphere.
Overview of the African palm weevil (Rhynchophorus phoenicis) as food and feed – A critical review
Authors: Siddiqui S.A. , Thanpandiyan K. , Adli D.N. , Yudhistira B. , Fernando I. , De Palo P.
Published: May 2024

Insects have long been a part of the human diet, but their appeal as a human meal has only grown in recent years due to their potential as a vast future food supply with high nutritional value and significant environmental benefits. The African palm weevil (APW) larvae (Rhynchophorus phoenicis) is one of the promising insects with promise in food application. This paper provides a comprehensive review of APW larvae based on bioecological, consumption, nutritional value, nutraceutical and pharmaceutical properties, and consumer acceptance. APW larvae are an alternative food, especially in the African region, that has been consumed by people for a long time. Over time, APW larvae consumption has developed both in terms of quantity and quality; this is indicated by an increase in APW farming followed by diversification of processed products. APW larvae contain high nutrients, including amino acids, fatty acids, and minerals. In several African countries, APW has been utilized in various dishes prepared using different methods. APW farming has economic potential that can increase people’s income. APW larvae are highly accessible, inexpensive, have low environmental footprints, and have the potential to solve food poverty in Africa. This study is intended to provide policymakers with a framework for developing and implementing more appropriate rules and regulations to support the expansion of the APW industry.
Crisis in South Korean cricket farms: Occurrence of Gryllus bimaculatus densovirus and its spread
Authors: Kim E. , Koo H.-J. , Kim J.-Y. , Baek J.H. , Kim C.-O. , Park K. , Yoon J.-S.
Published: May 2024

The emergence and spread of densovirus infections pose significant challenges to the cricket industries in South Korea, where two-spotted crickets (Gryllus bimaculatus) serve as crucial feed for fish and reptiles. Diseased two-spotted crickets were collected from the reported farms and examined to identify pathogens. Through metatranscriptome analysis and virome sequencing, we elucidated the complete genome sequence of Gryllus bimaculatus densovirus (GbDV) and characterized its structural and nonstructural protein coding regions, including inverted terminal repeats (ITRs) and conserved motifs; as of yet, there is no reported densovirus infection in G. bimaculatus. Electron microscopy confirmed the presence of densovirus particles in infected crickets. Viral load assays were conducted in a timely and regional manner across 20 cricket farms to monitor the spread of the virus and its adverse impact on cricket availability in the market throughout South Korea. The rapid decline in the number of cricket farms highlights the urgent need for proactive disease surveillance and control methods to mitigate the economic and ecological consequences of densovirus infections.
Description of two new species of Sycophilodes (Hymenoptera: Chalcidoidea: Epichrysomallidae) from China with a key to species of the genus
Authors: YANG XIAO-FANG , RASPLUS JEAN-YVES , FENG ZHI-RONG , MIAO BAI-GE , PENG YAN-QIONG , YANG DA-RONG , CHEN HUAYAN , WANG BO
Published: May 2024

Two new species of Epichrysomallidae (Hymenoptera: Chalcidoidea), Sycophilodes densfemur Yang, Peng and Rasplus sp. nov. and S. altissimae Yang, Peng and Rasplus sp. nov. are described and illustrated. These species are early gall makers developing in figs of Ficus altissima Blume, 1825 (Moraceae) in Xishuangbanna, China. Their biology is discussed and an identification key to the described species of Sycophilodes is provided.
Inorganic Nitrate Determination Employing Co(II) Complex Potentiometry
Authors: Khan Mohd. Farhan , Mustafa Jawed , Qahtani Faez , Umar Khalid , Muhaisen Hasan M. H. , Abdullah M. M. , Mohammad Luqman
Published: May 2024

The research presented here describes the development of membranes made of polymeric materials with unique cobalt(II) complexes to identify nitrate anions in water. The authors of the study precisely coordinated cobalt(II) ions with a neutral tetradentate ligand known as N,N-Ethylene
bis(Salicylideneaminato) to develop an efficient anion-binding carrier with nitrate sensitivity. Good nitrate specificity was accomplished by incorporating these Co(II) complexes onto membranes alongside the plasticizer dibutyl phthalate (DBP). The improved Co(II)-based sensors achieved near-Nernstian
response slopes throughout a large linear detecting span of 5.0×10−6 to 1.0×10−1 M nitrate, retained functionality from pH 3 to 12, and responded quickly in about 15 seconds. Potentiometric sensitivity factor analyses revealed that the fabricated
Co(II) sensor membrane had a higher sensitivity for nitrate compared to more conventional ions. In general, this study highlights the potential of customized Co(II) complexes incorporated into polymeric membranes to be selective and efficient potentiometric sensors for detecting nitrate anions
in water bodies. It serves as a foundation for developing enhanced nitrate detection systems for use in important environmental as well as health monitoring processes.
Guaranteeing Human Rights? Italian ‘Gastarbeiter:innen’ and Housing Activism in 1960s and 1970s West Germany
Authors: Jacobson Sarah
Published: May 2024

This article examines migrant grassroots movements that invoked universalising rights’ languages to assert claims to decent and affordable housing in West Germany in the 1960s and 1970s. It focuses on Southern Italian migrant ‘guest workers’ who utilized rights’ claims to highlight dismal living conditions and the lack of access to affordable housing for migrant families in their new communities. Migrants’ claims then ‘scaled up’ to the level of international relations and the European Parliament as state actors and advocacy groups couched migrant housing conditions in terms of human rights. No matter the forum, ideas surrounding human rights created frameworks of debate over the West German welfare state, the free movement of labour within the European Economic Community, and even visions of European citizenship and integration. As such, this article illustrates the disparities between canonising human rights on paper and the challenges of guaranteeing said rights on the ground, particularly for populations not confined to the boundaries of their own nation-state.
Chinese Exceptionalism? Folk Religions and Subjective Well-being
Authors: Luo Lang
Published: May 2024

Folk religions are reviving in contemporary China. They are distinctive from institutionalized religions and share many qualities with the emerging religious phenomena in the West. Despite their significance, however, the lack of concise frameworks and causal analysis methods has hindered a deeper understanding of these religions. By integrating psychological and sociocultural perspectives, this study concentrates on subjective well-being and tailors a micro model applicable to analyzing Chinese folk religions, along with a novel instrumental variable for causal identification. Empirical evidence suggests that folk religions have negative effects on subjective well-being, resulting in a 17.3 percent decrease in subjective well-being compared to the sample mean. This is primarily due to believers seeing folk religions as mere means for achieving earthly targets, therefore suffering from strengthened negative senses and motivated radical behaviors. Nevertheless, investing in folk religions to a high degree might transform believers’ attitudes from seeing folk religions as means to seeing them as ends, thereby alleviating the negativity. This alleviation is mainly derived from positive senses, self-regulation, and inclusive attitudes towards society. Hence, taking religions more seriously and not utilitarianly, or fulfilling unmet targets more effectively, are two paths to eliminate the negative effects.
Navigating Risks and Reducing Harm: A Gendered Analysis of Anabolic–Androgenic Steroid Users Within the Risk Environment Framework
Authors: Piatkowski Timothy , Dunn Matthew
Published: May 2024

Introduction: The existing body of literature on harm reduction for those who use anabolic–androgenic steroids (AASs) predominantly concentrates on men, thereby neglecting the unique challenges faced by women in this context. Using a risk environment framework, the aim of this study was to examine the gendered harm reduction practices of male and female AAS users. The study explores their awareness of the potential harms associated with AAS use, the strategies they employ to manage those risks, and the support systems they utilize for harm reduction. Methods: The study employed purposive sampling to recruit 25 individuals (16 females and nine males) who used AAS. In-depth, semi-structured interviews were conducted and transcribed; thematic analysis was employed. Results: Both male and female users were aware of the risks and side effects of AAS. They also often trusted coaches for advice regarding AAS use, and some found peer support for open discussions. Participants also indicated the importance of verifying the legitimacy and safety of AAS. Men considered these to be manageable while women aimed to avoid them, particularly the masculinizing effects. Women downplayed the persistence of side effects and fertility challenges. Harm reduction strategies involved both men and women monitoring their health through personal cues and blood tests. However, women placed a greater emphasis on various physiological measures in their health monitoring practices. Post-cycle therapy was less discussed among women. Discussion: Overall, the study provides insights into the awareness, strategies, and support systems employed by men and women who use AAS for harm reduction purposes. There is a need to adopt a comprehensive harm reduction approach that recognizes the unique needs and experiences of women who use AAS. We emphasize the need for comprehensive education, supportive healthcare providers, and responsible coaching to minimize potential risks and ensure the well-being of individuals using AAS.
Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet)
Authors: Kostoglou Kyriaki , Bello-Robles Felipe , Brassard Patrice , Chacon Max , Claassen Jurgen AHR , Czosnyka Marek , Elting Jan-Willem , Hu Kun , Labrecque Lawrence , Liu Jia , Marmarelis Vasilis Z , Payne Stephen J , Shin Dae Cheol , Simpson David , Smirl Jonathan , Panerai Ronney B , Mitsis Georgios D
Published: May 2024

Cerebral Autoregulation (CA) is an important physiological mechanism stabilizing cerebral blood flow (CBF) in response to changes in cerebral perfusion pressure (CPP). By maintaining an adequate, relatively constant supply of blood flow, CA plays a critical role in brain function. Quantifying CA under different physiological and pathological states is crucial for understanding its implications. This knowledge may serve as a foundation for informed clinical decision-making, particularly in cases where CA may become impaired. The quantification of CA functionality typically involves constructing models that capture the relationship between CPP (or arterial blood pressure) and experimental measures of CBF. Besides describing normal CA function, these models provide a means to detect possible deviations from the latter. In this context, a recent white paper from the Cerebrovascular Research Network focused on Transfer Function Analysis (TFA), which obtains frequency domain estimates of dynamic CA. In the present paper, we consider the use of time-domain techniques as an alternative approach. Due to their increased flexibility, time-domain methods enable the mitigation of measurement/physiological noise and the incorporation of nonlinearities and time variations in CA dynamics. Here, we provide practical recommendations and guidelines to support researchers and clinicians in effectively utilizing these techniques to study CA.
Neoliberal Feminism and Women's Protest Motivation
Authors: Bongiorno Renata , Ryan Michelle K. , Gibson Olivier , Joyce Hannah
Published: May 2024

A popular form of neoliberal feminism seeks to advance gender equality in leadership and beyond by encouraging women to be resilient as individuals. By locating career advancement as within an individual's control, recent research has shown that this focus subtly shifts the blame for gender inequality onto women and reduces support for needed structural changes to tackle gender discrimination. We extend research into neoliberal feminism by examining anticipated negative effects on women's protest motivation. Across four studies in the United Kingdom (total N = 1,168), undergraduate women students and employed women with university degrees in both the control and resilience conditions first read about gender inequality. Participants in the neoliberal feminist conditions then read messages promoting individual resilience as key to women's advancement (Study 1–3) or participated in activities designed to build their own resilience as individuals to help them advance (Study 4). In Studies 1, 3, and 4, participants in the neoliberal feminist conditions compared to the control had lower collective action intentions – a negative effect that was either indirect, via reduced perceptions of gender discrimination (Studies 1 and 4) and reduced anger over inequality (Study 1), or direct (Study 3). Together, these studies provided partial support for our hypothesis that neoliberal feminism can undermine women's protest motivation. Future research can help establish how contextual and other factors contribute to the strength of these effects and explore how feminists can better harness messages of resilience. To advance gender equality, our findings suggest that advocates should focus less on individualistic solutions and more on addressing structural barriers, laying the groundwork for effective protest action and social change. Additional online materials for this article are available on PWQ's website at http://journals.sagepub.com/doi/suppl/10.1177/03616843241238176 .
Chinese Negative Reactions to Positive Gender Stereotypes: A Perspective of Psychological Reactance Theory
Authors: Wang Zhen , Zhao Li , Zuo Guoguo , Guan Jian
Published: May 2024

Individuals’ lives depend heavily on their freedom, which is why they may respond with reactance if freedom is threatened. Our research, which spans four studies with 1,486 Chinese students as participants, from the perspective of psychological reactance theory, provides evidence that positive gender stereotypes can provoke targets’ negative reactions. In Study 1, participants who heard a speaker state a positive gender stereotype (e.g., “women are beautiful” and “men are strong”) disliked the speaker more, believed that the speaker was more gender prejudiced, and experienced stronger negative emotions than those who heard no stereotype. In Studies 2−4, freedom threat was a crucial mediator in the relation between the positive gender stereotype and targets’ negative reactions. Furthermore, depersonalization also played a parallel mediating role. Although positive gender stereotypes seem superficially complimentary, they may have detrimental effects on interpersonal relations. Our research suggests that people should refrain from using stereotypes in their interpersonal interactions whenever possible. Even though people may sometimes inevitably convey positive stereotypes to others, they should be given the freedom to minimize the negative consequences of such stereotypes. Additional online materials for this article are available on PWQ's website at http://journals.sagepub.com/doi/suppl/DOI: 10.1177/03616843241242711
Delirium Associated with COVID-19 in Critically ill Children: An Observational Cohort Study
Authors: Gray Meghan C. , Traube Chani , Sewell Taylor B. , Geneslaw Andrew S.
Published: May 2024

Objective

Delirium is an under-recognized problem in critically ill children. Although delirium is common in adults hospitalized with COVID-19, the relationship between pediatric COVID-19 and delirium has not been described. To address this gap, we characterized delirium in critically ill children with different manifestations of COVID-19 and investigated associations among demographic, disease, and treatment factors. We hypothesized that multisystem inflammatory syndrome in children (MIS-C) would be associated with a higher incidence of delirium given its underlying pathophysiology of hyperinflammation.

Design

Retrospective, single-center cohort study.

Setting

Quaternary-care pediatric intensive care unit (PICU).

Patients

Children less than 18 years of age hospitalized in the PICU between March 2020 and March 2023 with either active SARS-CoV-2 infection or serological evidence of prior infection.

Measurements and main results

The cohort included 149 PICU hospitalizations among children with evidence of COVID-19. Patients were categorized by reason for PICU admission: 75 (50%) for COVID-19 respiratory disease, 36 (24%) MIS-C, and 38 (26%) any other primary reason with positive COVID-19 testing. Delirium was diagnosed in 43 (29%) patients. Delirium incidence was highest in patients requiring invasive mechanical ventilation (IMV) (56% vs 7.5% in patients who did not require IMV, p < .001). Patients who were exposed to opioids, dexmedetomidine, paralytics or benzodiazepines more frequently experienced delirium compared to those unexposed ( p < .001, p < .001, p < .001 and p  =  .001, respectively). After multivariable adjustment, delirium was associated with IMV (HR 3 [95% CI 1.5–5.7]), female sex (HR 2.4 [1.2–4.7]), and developmental disability (HR 3.4 [95% CI 1–11.1]). There was no association between delirium and reason for PICU hospitalization.

Conclusions

Delirium was common among children hospitalized with COVID-19. The overall incidence was much less than has been reported in adults with COVID-19. Delirium reduction efforts should focus on children with developmental disability and minimizing ongoing risks during IMV.
COVID-19 Narratives from Those with Chronic Illness
Authors: Clark Clayton C. , Nold Laura
Published: May 2024

Older, chronically ill adults already at risk for social isolation experienced exacerbated isolation due these COVID-19 interventions. This study aimed to describe the narratives of older adults with chronic illness during COVID-19, connect them to the broader literature and use them as exemplars for a holistic analysis of policies for respiratory pandemics. Using narratives related to COVID-19 experiences from a larger research study on spiritual coping with chronic heart failure, the study rendered the themes of isolation, uncertainty, and making the best of it which were connected to additional literature validating the experiences of the participants. The narratives and their themes were then used as a launching point for a holistic analysis of the pandemic response and its effects on well-being for older adults. Clinicians and policymakers should carefully consider not just the physical health burden of a respiratory pandemic on older, chronically, ill adults, but also the holistic health burdens of policies. With these broader health domain considerations in mind ethical and practical recommendations future responses to viral respiratory pandemics are offered.
Unraveling the Link Between Childhood Psychological Maltreatment and Mental Well-Being: The Serial Mediation Role of Family Belongingness, Family Coherence, and Loneliness
Authors: Karaagac Zahide Gul , Satici Seydi Ahmet , Engin Deniz Mehmet
Published: May 2024

Childhood psychological maltreatment has a significant impact on family-related factors and adult mental health, emphasizing the importance of investigating its effects and developing appropriate interventions. Loneliness is also an important factor that needs further exploration in relation to these variables. This study aims to gain a better understanding of the relationship between these variables and to examine the role of family belongingness, family sense of coherence, and loneliness as chain mediators between childhood psychological maltreatment and adult mental well-being. Data from 369 participants residing in 46 different cities in Turkey were analyzed. The participants were selected to represent a diverse range of backgrounds and living conditions, predominantly female ( n = 282, 76.4%) and well educated ( n = 300, 81.3%). A structural mediation model was used to analyze the data. The variables of childhood psychological maltreatment, family belongingness, family sense of coherence, loneliness, and adult mental well-being were measured and examined for their relationships. The findings of the study indicated that family belongingness, family sense of coherence, and loneliness mediate the association between childhood psychological maltreatment and adult mental well-being. Childhood psychological maltreatment poses a risk to a positive family sense of coherence and family belongingness, while loneliness emerges as a significant factor affecting adult mental well-being. These findings highlight the importance of addressing childhood maltreatment and promoting family support and coherence to enhance mental well-being in adulthood. Further research and interventions in this area are warranted.
A Systematic Review and Narrative Synthesis of Single-Case Group Contingency Interventions Targeting Prosocial and Antisocial Behavior in School Children
Authors: Brennan Ciara , Deegan Avril , Bohan Clare , Smyth Sinéad
Published: May 2024

Group contingencies are well established as methods for reducing disruptive classroom behaviors and increasing academic behaviors. However, their role in increasing prosocial behaviors has not yet been explored to the same extent. We conducted a systematic review of the single-case literature to synthesize the types of prosocial and antisocial behaviors targeted in school settings, the short-term and long-term behavioral contingencies used to target these behaviors, and the quality of the literature. We searched five databases for studies exploring the use of group contingencies to increase prosocial behaviors or decrease antisocial behaviors in children. Our narrative synthesis of the twenty-two included studies noted contingencies employed in these interventions consisted of either positive reinforcement or a combination of positive reinforcement and positive punishment. Of the 22 studies included for review, none met the What Works Clearinghouse Design Standards without reservations. Interobserver agreement and demonstration of effects over time were the most commonly unmet design standards. Future research should seek to encourage greater focus on both prosocial behavior and positive behavior change mechanisms. PROSPERO ID: CRD42022337025.