bluuebunny/crossref_metadata_2025 huggingface dataset:
Novo Ensino Médio na Paraíba: a perspectiva de estudantes e professores de Escolas Cidadãs Integrais Técnicas.
Authors:   , Clara Oliveira da Costa Maria
Published: July 2023

O Novo Ensino Médio é proveniente da Lei 13.415/17, que faz uma nova organização curricular, flexibilizando o currículo com o objetivo anunciado de atender aos interesses dos estudantes, e instituindo o ensino médio em tempo integral. Anteriormente à reforma do ensino médio, a Paraíba já implantava uma nova organização curricular, com o ensino em tempo integral. Modelo criado com o apoio do Instituto de Corresponsabilidade Educacional (ICE), voltado para atender às demandas do mercado de trabalho. A ECIT já apresentava redução da carga horária para as disciplinas da formação geral básica, implementação da base diversificada e base técnica no currículo de ensino médio, e o ensino em tempo integral.Freitas e Laval já identificavam a conduta neoliberal presente na educação brasileira. A presente pesquisa objetiva compreender a perspectiva dos estudantes e professores das Escolas Cidadãs Integrais Técnicas com a implementação do Novo Ensino Médio na Paraíba. Para identificar a perspectiva dos professores, foi realizado um grupo focal com 11 professores de Ciências Humanas da rede estadual de ensino da Paraíba, com duração de 3 horas. Já com os estudantes, foi realizado um questionário online, e foram coletadas 222 respostas de alunos que estão cursando o ensino médio nas Escolas Cidadãs Integrais Técnicas da Paraíba. Os professores demonstram insatisfação com o modelo, reforçam o caráter impositivo das ECITs e lamentam a formação insuficiente que receberam para compreender as mudanças curriculares. Entre os resultados é possível destacar, quando os estudantes foram perguntados sobre disciplinas que poderiam ter carga horária reduzida ou ser eliminadas, entre as 221 respostas, os estudantes puderam escolher mais de uma alternativa, e 67 (30,3%) discentes indicaram Projeto de vida, 60 (27,1%) optaram por Eletiva, 50 (22,6%) indicaram Avaliação semanal, 36 (16,3%) escolheram Pós-médio e 26 (11,8%), optaram pelas disciplinas empreendedoras. Foi questionado aos estudantes, qual seria a carga horária adequada a formação deles, de acordo com a realidade de cada um, e 63 (28,4%) consideram 6 horas, seguidos de 61 (27,5%) que consideram 5 horas ou menos. Contudo, faz-se necessário debater a proposta, considerando as perspectivas do público que vivencia as mudanças.
Educação em tempo de pandemia: ensino remoto e os processos de ensino aprendizagem na disciplina de Sociologia ministrada nas escolas estaduais situadas no município de Sertânia - PE.
Authors:   , Cardos Gondim Esequias
Published: July 2023

A conjuntura brasileira, no período de pandemia da COVID 19, tem apresentado novos desafios para o conjunto da população, acirrando ainda mais as desigualdades sociais, econômicas, culturais, educacionais etc notadamente expressas nos elevados índices aferidos pelos órgãos competentes. No campo da educação, a tendência tem sido o aprofundamento da adequação da educação ao desenvolvimento socioeconômico, no formato enxuto, barato e flexível. Nesse sentido, o ensino remoto emerge como um dos principais elementos utilizados para o enfrentamento dos problemas oriundos desse contexto. Atentos a essa realidade, a presente dissertação buscou analisar os impactos provocados pelo ensino remoto nos processos de ensino e aprendizagem vivenciados na disciplina de Sociologia, ministrada nas escolas estaduais sediadas no município de Sertânia PE. Para isso, foi utilizada uma abordagem qualitativa por uma perspectiva históricocrítica, tendo por instrumento um roteiro de questões direcionado aos professores da disciplina dessas escolas, sendo possível, portanto apreender as convergências, divergências, contradições, limites e possibilidades, a partir de uma perspectiva de análise que considerou o objeto como parte constitutiva de uma totalidade histórica. Nesse sentido, é importante destacar que o objeto foi situado no contexto da luta de classes, onde projetos diferenciados de educação se conflitam, uma vez que os interesses são antagônicos, sendo, portanto, necessário compreender as mediações que permitisse entender a s questões relacionadas tanto ao campo da particularidade – a exemplo do que acontece na escola, na prática pedagógica cotidiana , quanto ao campo da universalidade – a exemplo do modo de produção capitalista, das reformas educacionais que vão se processa ndo em diversos países. Quanto aos fundamentos teóricometodológicos, recorreuse principalmente às obras de Saviani, Freire. Ficou evidenciado que a pandemia precarizou ainda mais os processos de ensino e aprendizagem nas escolas onde a pesquisa foi realizada, dadas as condições objetivas desfavoráveis, visivelmente expressas no decorrer do ensino remoto que foi empregado para que as escolas continuassem a cumprir com o seu papel social.
Interface digital: a sociologia das tecnologias digitais de informação e comunicação na escola.
Authors:   , Maria de Oliveira Santos Kátia
Published: July 2023

Na pós-modernidade, novos valores fundamentam as formas sociais de existir e de transformar o mundo. Esses valores estão presentes na escola enquanto Instituição social que (re)produz normas, significados e ações que direcionam o agir, o sentir e o pensar dos sujeitos na pós-modernidade. Nesse sentido, uma das formas de existência na escola, assim como na sociedade pós-moderna, é dada pela mediação das tecnologias. Essa mediação constrói sentidos outros de se perceber, perceber o outro e estar no mundo. Chamamos essa mediação de aparelhamento digital, onde os sujeitos existem e produzem sentidos de mundo através do uso de tecnologias digitais da informação e comunicação. Em sala de aula, o aparelhamento digital nos leva a questionar os processos de ensino e de aprendizagem. Assim, como problema de pesquisa, trouxemos: quais as implicações do aparelhamento digital para o ensino de Sociologia no Ensino Médio? Nosso objetivo foi compreender quais as implicações do aparelhamento digital para o ensino de Sociologia no Ensino Médio. Propomos, enquanto caminho teórico-metodológico, o uso da Análise Sociológica do Discurso, visto que entendemos os discursos enquanto formas sociais que são internalizados e são modulados pela realidade social, pela construção dos sentidos e significados que estruturam a existência social e que são apreendidos pelos sujeitos nos processos de subjetivação e de socialização. Nosso objeto de pesquisa foi ganhando contornos a partir das contribuições teóricas de Zygmunt Bauman (2001; 2007; 2009), Pierre Bourdieu (1998; 2000; 2011) e Pierre Lévy (1989; 1998). Pelos constructos sociológicos de tais autores, percebemos a necessidade de investigar os processos de aprendizagem no ensino de Sociologia, no Ensino Médio, através do aparelhamento digital. A pesquisa permitiu perceber a necessidade de discutir as implicações do aparelhamento digital no ensino de Sociologia, visto que o que está em evidência é a própria formação humana.
A Simulation-Based Comparative Study of Controlled Delay (Codel) with Random early Detection (Red) for Network Performance Evaluation
Authors: T.A. Komolafe , O.A. Oladimeji , O.O. Adiamo , O.O. Oyebode , R.O.A. Oyeniyi
Published: July 2023

The rising need to use the internet for time/delay-sensitive applications with different Quality of Service (QOS) requirements has made network management and control even more challenging. The current congestion avoidance and control mechanisms for Transport Control Protocol (TCP) are insufficient to offer good service in all circumstances. A few decades ago, the TCP successfully regulated Internet congestion control. However, it is already widely acknowledged that TCP has reached its limits and that new congestion control protocols will be required in the near future. This has prompted a significant amount of research on novel congestion control designs that will meet the demands of the future Internet. With widespread public attention and study, the full buffer problem has not gone away, but rather worsened. As a result, there has been a surge in interest in using Active Queue Management (AQM) in Internet routers to minimize queue latency. The effectiveness of a recently developed AQM, Controlled Delay (CoDel) algorithm, designed to work in today’s network setups and can be deployed as a main part of the bufferbloat solution, is evaluated in this research study. CoDel's effectiveness is evaluated by running simulations in ns-3 and comparing its results to that of Random Early Detection (RED), another promising network queue management technique.
Network Analysis on Phase 1B Building of the University Health Centre, FUTA, using Critical Path Method (CPM) and Program Evaluation Review Technique (PERT)
Authors: O.A. Oladimeji , M.A. Akomolafe , T.A. Lasisi , O.A. Oloja , L.A. Oladimeji
Published: July 2023

Project planning and scheduling plays a vital role in estimating the time and cost angle of a project. Finalizing a project on time and within the budget is challenging. This study focused on finding the shortest possible time required to complete the phase 1B Building project of the University Health Centre, FUTA and also to evaluate the probability of completing the project within the stipulated time. This project work has been able to give a concise view about network analysis in building construction; definitions of some terms commonly used in network analysis was also stated. Also, an introduction to CPM and PERT was stated; assumptions of CPM, advantages and disadvantages of CPM were stated; assumptions, advantages and disadvantages of PERT were also stated. Data analysis was carried out and all the possible routes of the activities involved in the building project were found; the location of the critical path of the building project was also found; the expected duration for every activity in the building project was determined; the probability of completing the project within the stipulated time was also evaluated. The results showed that there is a 50% chance for the project to be completed within the stipulated time. With the information gathered on the building project, the project was delayed due to some factors such as low circulation of money, inadequate equipments, loss of some weeks due to a change in plan, and inadequate manpower; thus, there was a two month difference between the initial completion and the now actual completion time.
The Effect of Butyrophenones for the Management of Primary Headache in the Emergency Department: A Systematic Review and Meta-Analysis
Authors: Alsuliamani Ahmed , Badawi Rizq , Hanel Erich , Bin Nafisah Sharafaldeen
Published: July 2023

BACKGROUND: The use of butyrophenones for headaches became plausible when the association was established between dopamine and headache. However, despite their positive effect on acute headaches, their use remains controversial.
AIM: The goal of this study is to ascertain whether the addition of haloperidol or droperidol to the treatment regimen for acute primary headache lowers the pain score of adult patients in the emergency department.
METHODS: A systematic review and meta-analysis was conducted. We searched the following databases for randomised controlled trials (RCTs): PubMed, Cochrane databases, and grey literature, from 1963 to October 2022. Included were RCTs conducted on the use of butyrophenones (IV haloperidol or IV/IM droperidol) in the acute management of primary headaches (diagnosed or undiagnosed), designated prospective, double-blind or open, using only the Visual Analogue Scale (VAS) with a specific measurement time. We excluded non-English studies that lacked translation, studies conducted on paediatric age groups, and studies conducted on animals.
RESULTS: Out of 49 articles we included seven, three of which investigated haloperidol. The mean difference in VAS score favoured haloperidol; -2.46 (95% CI: [-4.11 to -0.81]), indicating a drop in VAS score of 2.5/10 units. The mean difference in VAS score for the use of droperidol was -0.35 (95% CI: [-1.24 to 0.54]).
CONCLUSION: Haloperidol can induce an acute 25% reduction in VAS score when added to the regimen for acute headache management. It also reduces the need for rescue medications and improves patient satisfaction. Nonetheless, considerable side effects cannot be overlooked.
A Comparative Study on the effectiveness and Tolerability of Mirabegron and Antimuscarinics in the treatment of Overactive bladder
Authors: Jose Sruthy , VP Anukrishna , K Ajayan Aarcha , Gopi Malavika , Rajendran Rohan , Vijayan Meenu
Published: July 2023

Background: Despite antimuscarinic treatment options being available as the first line agents for overactive bladder (OAB), there is still a need for distinct treatment approaches to manage its suboptimal response and noncompliance. Mirabegron, a β3-adrenoceptor agonist, could be a better alternative to antimuscarinics in OAB treatment with a good effectiveness/tolerability balance. Aim: To compare the clinical profile of mirabegron and antimuscarinics in the treatment of overactive bladder. Method: A prospective, observational study was conducted in two groups of patients who received either mirabegron (n=120) or antimuscarinics (n=120) for the treatment of OAB. Effectiveness of the drugs were assessed at baseline, 4 and 8 weeks after the treatment using the Overactive Bladder Symptom Score (OABSS) and International Prostatic Symptom Score (IPSS) questionnaires. The safety assessment was done by measuring the post-void residual (PVR) urine volume and assessing the adverse drug reactions (ADR). The probability and severity of the ADRs were measured using Naranjo scale and Hartwig’s scale respectively. Also a subgroup analysis was carried out to compare the effectiveness of the two drugs in patients with OAB related to benign prostatic hyperplasia (BPH). Results: The overall effectiveness of antimuscarinics and mirabegron was found to be similar, but mirabegron showed better reduction in the daytime frequency (p=0.049). They also differ in safety profile with the overall incidence of adverse events being significantly higher in antimuscarinics group (15.83%) (19/120) than in the mirabegron group group (1.7%) (2/120) (p<0.001). In the patients with OAB related to BPH also, there was a better reduction in the daytime frequency with mirabegron than with antimuscarinics, with overall effectiveness between groups being similar. In addition, mirabegron did not worsen the voiding symptoms and was found to be a better combination with alpha1 blockers than the antimuscarinics in patients with OAB related to BPH. No significant change was there in the PVR values within and between the groups. Conclusion: Mirabegron is a better alternative to antimuscarinics in the treatment of OAB with a distinct effectiveness/tolerability balance especially in patients with OAB related to BPH.
Stability Indicating RP-HPLC Method Development and Validation for the determination of Pretomanid an anti-bacterial drug
Authors: Srinivasa Rao Peddi , Siva Rao Tirukkovalluri , Sailaja B. B. V. , Suman Pallapati , Jai Sri G.
Published: July 2023

A new simple, rapid, accurate and stability indicating RP-HPLC method have been developed and validated for estimation of Pretomanid is an anti-bacterial agent in pharmaceutical dosage form. The RP-HPLC analysis was performed by using Xtimate C18 column (250mm × 4.6mm; 5µm) with Methanol: Acetonitrile: Ammonium phosphate buffer in the ratio of 55:40:05 (v/v/v) as mobile phase at a flow rate of 1.0mL/min and detected at 262nm wavelength. The calibration curve was linear over the concentration range from 10 to 40µg/mL and correlation coefficient was found to be 0.99. LOD and LOQ were estimated as 0.30µg/mL and 5.0µg/mL respectively. The % recovery was achieved from 98.67% to 99.96%. The method was applied for estimation in its pharmaceutical dosage form and assay result was 98.9% label claim. Proposed method showed excellent linearity, accuracy, precision, specificity, robustness, LOD, LOQ, and system suitability results within the acceptance criteria as per ICH guidelines. The Pretomanid drug was subjected to stress condition of Hydrolysis, Oxidation, Photolysis and Thermal degradation, Forced degradation study was carried out and the degradation products were well resolved from the pure Pretomanid drug. The proposed method was successfully applied for the estimation of Pretomanid drugs in commercial dosage form.
Pharmacognostic Evaluation of Ipomoea hederifolia L.
Authors: Kurian Priya , Banurekha J. , Venkateswarlu BS. , Kumar M.
Published: July 2023

Ipomoea hederifolia commonly known as Red morning glory or Scarlet creeper has diuretic, anthelminthic, laxative, carminative and anti-inflammatory qualities. In traditional Chinese medicine, it is used as cathartic, diuretic and expectorant. The plant is known to have sternutatory action. This study was aimed to investigate the pharmacognostic and physicochemical parameters of the leaf and stem. Macroscopic, microscopic and physicochemical parameters of the leaf and stem were investigated using standard methods. The macroscopy showed it is a twining vine. Microscopic studies revealed the leaves are dorsiventral in nature. Presence of cluster crystals of calcium oxalate, paracytic stomata, unicellular trichomes, bicollateral vascular bundles were also observed. The physicochemical parameters such as different ash values and extractive values were also investigated. The present study includes macroscopic and microscopic characters of the stsem and leaf of Ipomoea hederifolia and these various parameters observed help to establish the correct identity of Ipomoea hederifolia to check the occurrence of adulteration.
Phytochemical Characterisation, Antioxidant and Antidiabetic activity of extracts of Neptunia prostrata Linn.
Authors: Chakraverty Raja , Chowdhury Mobaswar Hossain , Adhikari Anjan , Chakraborty Pranabesh
Published: July 2023

The herb Neptunia prostrata Linn. Is belonging to the family Mimosaceae have been used in folkloric medicine in the North-eastern states of Indiaof Assam and Tripura by indigenous herbal healers since time immemorial but there is a scarcity of any background study documenting its use as an antimicrobial herb. For the same, plants were collected and authenticated. Following identification of these herbs methanolic, ethanolic, pet ether and chloroform extracts were prepared using soxhletion. Acute toxicity study as per OECD guidelines 420 was assessed in wistar albino rats and in swiss albino mice (n=5) of both sexes at doses of 2000mg/kg body weight and did not reveal any morbidity or mortality in the animals within the stipulated period.Phytochemical screening was performed on all four extracts of Neptunia prostrata. Phytochemical constituents depicted presence of glycoside, flavonoids in only ethanolic, methanolic and chloroform extracts. Alkaloids were present in the chloroform extract. The antimicrobial activity was performed by disc agar diffusion method with respect to amoxicillin at standard doses against ATCC strains of Gram positive Staphylococcus aureus, Bacillus subtilis and Gram negative Salmonella typhi. The herbs showed antioxidant activity comparable to standard antioxidants in-vitro such as Ascorbic acid (Vitamin C) with comparable IC 50 values. Results of the antibacterial assay on the basis of zone of inhibition (mm) and MIC values of extracts of the extract (NPHE) under study to suggest these two indigenous herb have conspicuous and potent putative role in the therapeutics of a vast plethora bacterial infections that need to be corroborated for the expansion of future prospective in-vivo studies with larger sample size.
Case Reports of Stevens Johnson Syndrome (SJS) Induced by Chemically Unrelated Drugs
Authors: Vangoori Yakaiah , Vishnu Kandra Naga , Kumar Uppala Praveen , Upendrarao U. , Saibaba S.V. , Krishna Balijepalli Murali , Lavanya Butti , M. Shabana SK.
Published: July 2023

Stevens-Johnson syndrome (SJS) is considered as serious mucocutaneous autoimmune disease which is potentially fatal. It may be initiated by medical treatment or infection and sometimes both may be triggering factors. Skin reactions involving loss of skin and mucus membrane and in severe cases, systemic symptoms may be appeared in SJS. In most of the cases medication is the causative factor. Toxic Epidermal Necrolysis (TEN) is a severe form of SJS, as it involves more than 30% of the skin surface with extensive damage to the mucous membranes. SJS and TEN are distinguished based on the extent of the detached skin surface area. It starts with flu-like symptoms, rashes with pain; the upper layer of affected skin dies, sheds and begins to heal after several days. In severe cases, it may leads to life threatening condition. Here we are presenting drug induced SJS in three different cases with different drugs. In first case, a 40-years male treated with Phenytoin 400mg for epilepsy, in second case, a 50-years male was given Amoxicillin + clavulanic acid-625 for some skin lesions and in third case, 50-years old female was given Methotrexate 7.5mg for Rheumatoid arthritis. In all the three cases, SJS symptoms were started within a period of 5-10days. All the symptoms and reactions were noticed and assessed for the confirmations of SJS.
Simultenious Estimation of Sodium Benzoate and Caffeine in Soft Drinks by UV Spectroscopy
Authors: Pravalika Manda , Archana Jorige
Published: July 2023

A simple spectrophotometric methods have been developed for the simultaneous estimation of sodium benzoate and caffeine from the food products Method-I simultaneous equation method involves the measurement of absorbance at two wavelengths 224nm (λ max of sodium benzoate) and 274nm (λ max of caffeine) using Water as diluent. Method – II Absorption ratio method involves the measurement of absorbance at two wavelengths 274nm (λ max of caffeine) and 241nm (λ max of Isobestic point). The method was validated as per ICH guideline rules in terms of accuracy (recovery study), precision, ruggedness, robustness and the validation parameters were within acceptable limits. The percentage recovery at various concentration levels varied from 99.5 to 100.6% for sodium benzoate and 99.3 to 98.3% for caffeine. Two popular soft drink brands were purchased from supermarket and evaluated for sodium benzoate and caffeine by simultaneous equation method and Q-absorption ratio method. The amount of sodium benzoate and caffeine found in sample 1is 150µg/ml and139µg/ml and in sample 2 is 179µg/ml and 190µg/ml respectively.
In Silico Identification of Potential Inhibitors of Substituted Quinazolin-4-One against Main Protease and Spike Glycoprotein of Sars Cov-2
Authors: K Kavitha , N Srinivasan , R Suresh , S Mohan
Published: July 2023

Quinazolin-4-one have been used to therapy a lot of afflictions of humans legendary works exemplify that it possesses various biological activities. In this research is proposed to discover the synthetic derived pyrazolone fused quinazolin-4-one and Spike protein of sars Co V II and to understand the Insilico molecular origin of its activity. Even though chemistry of quinazolin 4 one being as an recognized area , day by day newer more complex derivatives are still being discovered. Moreover, an assortment of prose quinazolinone exibits a strong lactam-lactim tautomeric interaction and further when the methyl group is present in the second position, the tautomeric effect is increased, including structural activity relationship studies of the ring system describe that the position 2,6,8 are very much important for structure activity studies as well as inclusion of different heterocyclic moieties at position 3 could be enhances the different types of biological activity as well as Antiviral activity. The newly designed and synthesized compounds which is subjected to docking analysis as well as Computational study was performed using Auto dock 4, soon after admetSAR, also pkCSM Servers, were used to investigate drug likeness prophecy. This study suggested that the designed novel pyrazolone fused quinazolin-4-one derivatives (QPZ1-QPZ5) which are likely against the Sars COV-2 enzymes with excellent binding affinity , further obey’s Lipinski rule. Utilizing contemporary strategies, these novel synthetic molecule origins might establish a reliable medication or support potential lead identification. Identified potential compounds can be further taken for experimental studies, spectral analysis.
Advanced Wound Care with Biopolymers
Authors: Choudhury Ananya , Venkatesh D. Nagasamy , Kumar P Jey , Mohammed Asheeq P M
Published: July 2023

Recent advancement of the scientific research in the area of wound management demonstrated huge possibilities of nature derived materials as a potential source in wound repairing and tissue engineering. Wound healing is one of the difficult challenges in healthcare area due to the complexity of the natural healing process which often delays due to several microbial infections. An ideal wound dressing should maintain the moisture as well as able to remove excess fluid from the wound bed, permits gaseous exchange and easily to be removed without trauma after application. Bio polymers are naturally occurring molecules derived from different source namely plant, microbes, aquatic animals. They fits ideally to the main criteria of wound dressing that is non-toxic and non-irritant. Various type of wound dressings including hydrogels, hydro-colloids, films, foams, sponges, and electro-spun nanofibres have been formulated and received an increased interest from researchers to incorporate biopolymers i.e. Alginate, Chitosan, Cellulose, Gelatin, Collagen or combination of them into these dressings due to their structural advantage of bio-mimicking and pro-healing intrinsic properties. Biomaterials for wound healing can be classified in different ways, depending on their source, chemical nature, and type of dressings. This review article highlights the versatile use of biopolymers along with the current research in the field of wound care.
Effect of different Processing and Preservation Techniques on Lycopene: A Mini Review
Authors: Rawat Shruti , Siddiqui Arshi , Singh Rajat
Published: July 2023

Lycopene is the principle pigment found in the majority of the red fruits and vegetables. It is rich in so many medicinal properties. Tomato and its processed products are also a good source of lycopene. Around 85% lycopene is found in tomato and its processed products. The bright red, eye catching hue of ripen tomato is a gift of this lycopene to the tomato.The growing demand of lycopene results in the major production of its products. Processing temperatures leads to the decreased quality of the lycopene in the final product. Isomerization and oxidation are mainly responsible for this. So, a proper processing time and temperature is needed which will deliver the lycopene in its full potential form to the consumers.
Oral Manifestations of “COVID-19” Infection
Authors: Kumar Bera Sayan
Published: July 2023

Corona virus disease spreads rapidly throughout the world and created public health emergency. This RNA virus shows different types of stains among which delta (B.1.617.2) stain is more dangerous due to its mutation although omicron (B.1.1.351) spreads more rapidly than other variants. Covid-19 manifest different oral lesions like ulcers, erosion, necrotising periodontal disease, red and white plaque, petechiae, herpetiform lesions, non-specific lesions, HSV-1, acute parotitis etc. This virus also leads to post complications like Mucormycosis, musculoskeletal problems, mental health problems. As this virus spreads through oral and nasal routes so it is important to identify oral lesions as early as possible, so that dentist and paramedical staffs take proper preventive measures.
Development and Characterization of Nanostructured Lipid Carrier for Topical delivery of Naringenin
Authors: Kumar Jangde Rajendra , Khan Tanveer , Bhardwaj Harish
Published: July 2023

Wounds are physical injuries that result in an opening or break of the skin, the proper healing of wounds is essential for the restoration of disrupted anatomical continuity and disturbed functional status of the skin. Healing is complex and initiated in response to an injury that restores the function and integrity of damaged tissues. Nanostructured lipid carriers (NLCs) for dermal application can provide enhanced skin permeation. Naringenin belongs to the ﬂavanone class of ﬂavanoids and is abundantly present in citrus fruits. It has therapeutic interventions as antioxidant, anti-inﬂammatory, antidiabetic, and anticancer agents. But some drawbacks include poor solubility, fast metabolism and inadequate bioavailabilityhinder the application of ﬂavanoids, which can be addressed through increased absorption, solubility and stability.The present study was aimed at formulating naringenin-loaded NLCs for reducing the skin irritation potential, increasing the drug loading capacity and prolonging the duration of action. Naringenin-loaded NLCs were prepared by hot melt microemulsion and hot melt probe sonication methods.The properties of the optimized NLCs such as morphology, size, Zeta potential, stability and Invitro drug release were investigated. Naringenin-loadedNLCs showed a sustained release pattern tested and were found to follow the Higuchi model of drug release. Stability studies indicated that the formulations stored at refrigeration and room temperature showed no noticeable differences in the drug content and release profilesIn vitro, after a period of 4 weeks. The results showed that the irritation potential of Naringenin was reduced, the drug loading was increased and the drug release was prolonged by the incorporationof naringenin into the NLCs.
Changing perception through the art of mathematical modeling
Authors: Jose Sayooj Aby , R. Raja
Published: July 2023

Nowadays, infectious diseases are disorders caused by organisms — such as bacteria, viruses, fungi or parasites. Many organisms live in and on our bodies. They’re normally harmless or even helpful. But certain microbes have the potential to cause disease in specific situations. It is possible for some infectious diseases to spread from person to person. Others are spread by animals or insects. In this study, we build certain fundamental models, such as SI, SIR, SIRS, and SEIR, and in numerical simulations, we take into account random parameters to determine the dynamics of the model’s behavior. Finally, we present several studies in mathematical modeling of real situation relevant to epidemiology and population dynamic systems.
Salient Beliefs in the Intention for Self-Care Behaviors when Facing Hypertensive Disorders in Pregnant Women
Authors: Ulloa Sabogal Iliana Milena , Arias Rojas Edier Mauricio
Published: July 2023

Introduction: Hypertensive disorders of pregnancy represent a maternal and perinatal health problem. Therefore, it is important to identify the beliefs preceding the determinants of health behaviors during pregnancy. Objective: To identify the salient beliefs in the intention for self-care behaviors when facing hypertensive disorders in pregnant women. Materials and Methods: A descriptive study with a quantitative approach guided by the Theory of Planned Behavior. Each questionnaire was designed and its semantic validity was assessed. The sample was convenience one and included 114 pregnant women enrolled in prenatal control at a health institution from Piedecuesta, Santander, who answered the questionnaire via telephone calls between January and February of 2022. Data analysis was descriptive, resorting to absolute and relative frequencies. Results: The positive behavioral beliefs were focused on the mother’s proper nutrition, the baby’s healthy growth and development, disease prevention and control during pregnancy, the mother’s relaxation and peace of mind, and blood pressure control and monitoring. Regarding normative beliefs, health personnel, mothers, husbands, and family members exert positive influences on each behavior. The following were acknowledged among the control beliefs: visiting family members promotes the practice of physical exercises; at the nutritional level, there is a habit of preferring low-salt preparations; both family and social support and habit and preference favor the consumption of fruit, vegetables, legumes and meats; lack of habit avoids the consumption of fats, flours, sugars, caffeine, alcohol, and cigarettes; purchase power favors calcium intake; taking a previous shower promotes rest and sleep, and going to pharmacies allows controlling blood pressure. Conclusions: Identifying the salient beliefs allowed determining those that need to be reinforced, negotiated, or restructured in achieving self-care behaviors when facing hypertensive disorders in pregnancy.
Effectiveness of an early operating room start time in managing pediatric trauma
Authors: Kym Dan , Kaur Japsimran , Pham Nicole Segovia , Klein Eric , Langner Joanna Lind , Wang Ellen , Vorhies John Schoeneman
Published: July 2023

Shoulder pain is a common musculoskeletal complaint, and rotator cuff (RC) pathologies are one of the main causes. The RC undergoes various tendinopathic and avascular changes during the aging process. Other degenerative changes affecting its healing potential make it an appealing target for biological agents. Platelet-rich plasma (PRP) has demonstrated the potential to deliver a high concentration of several growth factors and anti-inflammatory mediators, and its clinical use is mainly supported by experiments that demonstrated its positive effect on muscle, ligaments, and tendinous cells. This review aimed to specify the role of PRP and its future applications in RC tendinopathies based on the current clinical evidence. Due to the different characteristics and conflicting outcomes, clinicians should use PRP with moderate expectations until more consistent evidence is available. However, it is reasonable to consider PRP in patients with contraindications to corticosteroid injections or those with risk factors for inadequate healing. Its autologous origin makes it a safe treatment, and its characteristics make it a promising option for treating RC tendinopathy, but the efficacy has yet to be established.
A NOVEL AGING MONITORING CIRCUIT
Authors: GHUKASYAN S.A.
Published: July 2023

Year by year there are numerous new requirements set to the lifetime and reliability of integrated circuits (IC), particularly in medical spheres and automotive applications. Consistent with technology downscaling the device reliability issues are increasing, but the quality requirements become stronger. Nowadays the aging phenomenon is one of the critical issues in systems with longer lifetime. Therefore, the monitoring of aging and its consequence compensation have become one of the key parts for today’s ICs.
A novel aging monitoring circuit is proposed in this paper. This new monitoring circuit monitors the aging degradation during lifetime of the IC and generates a binary co¬d¬e. This code is applied to the inputs of compensation circuits, which compensates the degrad¬ati¬on in the critical blocks throughout their lifetime. Monitoring circuit is realized with a 14 nm technology node and simulations proved the results’ validity.
Rezension von: Oberst, Manuela, Exercitium, Propaganda und Repräsentation
Authors: Scheinhammer-Schmid Ulrich , Oberst Manuela
Published: July 2023

Manuela Oberst: Exercitium, Propaganda und Repräsentation. Die Dramen-, Periochen- und Librettosammlung der Prämonstratenserabtei Marchtal (1657-1778) (Veröffentlichungen der Kommission für geschichtliche Landeskunde in Baden-Württemberg. Reihe B 179). Stuttgart: W. Kohlhammer 2010. 333 S., 8 Abb., kart., 1 CD-ROM., 38,00 EUR.
Rezension von: Eitel, Peter, Der Weg ins Königreich Württemberg (1800-1870)
Authors: Lang Stefan , Eitel Peter
Published: July 2023

Peter Eitel: Geschichte Oberschwabens im 19. und 20. Jahrhundert. Bd. 1: Der Weg ins Königreich Württemberg (1800–1870).Ostfildern: Jan Thorbecke Verlag 2010. 400 S., 29,90 EUR
Rezension von: Raberg, Frank, Biografisches Lexikon für Ulm und Neu-Ulm
Authors: Palaoro Simon , Raberg Frank
Published: July 2023

Frank Raberg: Biografisches Lexikon für Ulm und Neu-Ulm 1802-2009. Ulm: Süddeutsche Verlagsgesellschaft im Jan Thorbecke Verlag 2010. 664 S., zahl. Abb., geb., 36,80 EUR
Rezension von: Spohr, Marc, Auf Tuchfühlung
Authors: Herkle Senta , Spohr Marc
Published: July 2023

Marc Spohr: Auf Tuchfühlung. 1000 Jahre Textilgeschichte in Ravensburg und am Bodensee (Historische Stadt Ravensburg 6). Begleitband zur gleichnamigen Ausstellung. Konstanz: UVK Verlagsgesellschaft mbH 2013; 160 S., zahlr. Abb., 14,99 EUR
Rezension von: Pfundner, Thomas; von Wistinghausen, Henning, Neubronn
Authors: Scheinhammer-Schmid Ulrich , Pfundner Thomas , Wistinghausen Henning von
Published: July 2023

Thomas Pfundner/Henning von Wistinghausen: Neubronn. Ein Schlösschen im Ulmer Winkel. Weißenhorn: Anton H. Konrad Verlag 2013; 84 S., zahl. Abb., geb., 19,90 EUR
Rezension von: Zimmer, Oliver, Remaking the Rhythms of Life
Authors: Wettengel Michael , Zimmer Oliver
Published: July 2023

Oliver Zimmer: Remaking the Rhythms of Life. German Communities in the Age of the Nation-State (Oxford Studies in Modern European History). Oxford: Oxford University Press 2013; XIV, 395 S., geb., 43,99 EUR
Rezension von: Magenau, Jörg, Brüder unterm Sternenzelt
Authors: Schwarzbauer Franz , Magenau Jörg
Published: July 2023

Jörg Magenau: Brüder unterm Sternenzelt. Friedrich Georg und Ernst Jünger. Eine Biographie. Stuttgart: Klett-Cotta 2012; 320 S., 22,95 EUR
Rezension von: Scheib, Karl Ulrich, Justiz unterm Hakenkreuz
Authors: Oppitz Ulrich-Dieter , Scheib Karl Ulrich
Published: July 2023

Karl Ulrich Scheib: Justiz unterm Hakenkreuz – Strafjustiz im Nationalsozialismus bei der Staatsanwaltschaft Ulm und bei den Gerichten im Landgerichtsbezirk Ulm. Ulm: Klemm und Oelschläger 2012; 275 S., 2 Abb., zahlr. Tabellen, 24,80 EUR
The quadripolar method applied to the results evaluation in social marketing projects
Authors: De Almeida Francisco Alberto Severo , Almeida Felipe Martins Severo de , Silva Armando Malheiro da
Published: July 2023

The social marketing campaigns are extremely important to help promote behaviours and attitudes that improve living conditions in society. But to consider the effectiveness of these practices, the verification and evaluation of its results are crucial points to give credibility to its actions. This article aims to present initial considerations for the elaboration of a research plan about the evaluation models of social marketing projects, based on the quadripolar method, which was idealized for the scientific research in social sciences. Thus, this document seeks to structure the scientific investigation bases according to the epistemological, theoretical, technical and morphological poles (basis of the quadripolar method), that will guide the execution of a research that has as one of its aims to evaluate the evaluation models of social marketing projects.
Asynchronous network firmware update over the air designed for wireless sensor and actuator networks
Authors: Luz Paulo Denis Gaecez da , Oliveira Luiz Fernando Pinto de , Nanni Marcelo , Manera Leandro Tiago
Published: July 2023

This paper improvies the traditional FOTA system to a more robust one named ANFUOTA. This technique is only applicable to systems without embedded operating systems and to microcontrollers without multiple flash memory bank. This novel system is capable of updating the firmware in an asynchronous mode via networks WSN/WSAN kind and furthermore, it guarantees that the system never be without a valid firmware or rather, it is immune of communication failure or loss of packets and even feeding loss, independently of the updating phase. Even during the memory rewriting, in case it happens a feeding failure, the system will begin all over again the recording in the next rebooting. The used technique foresses an updating via networks WSN kind in an asynchronous mode and the firmware can be received in a distributed way in time and in many pieces or capable of being continuous. During this phase, the system remains online and doesn't enter in recording mode, keeping its activity on network. The system guarantees immunity in face of feeding loss and loss of packets by the network in all phases of updating, enabling updating all devices in network, simultaneously.
Inclusive mathematics education: special education paradigms and possibilities of pedagogical practices
Authors: Moura Ellen Michelle Barbosa , Moreira Geraldo Eustáquio
Published: July 2023

The challenge of inclusion is constant and is in historical development with progress, setbacks, conflicts. Therefore, the objective of this article is to analyze the paradigms present in the history of Special Education and their possible impacts and presence in current times regarding the pedagogical practices of teachers who teach Mathematics.The study has a qualitative, exploratory approach; data production procedures are bibliographic and documental research, followed by descriptive analysis. The research reveals that there are social, cultural and historical factors, present in the history of Brazil and of school education, which is marked by segregation principles, dichotomous vision between the so-called "normal" and "abnormal", ableism, which constitute constant obstacles in the search for Inclusive Education and differentiated pedagogical practices in Mathematics that consider diversity as part of the human constitution. In this context, the pedagogical practice of the teacher who teaches Mathematics, often, to be based on the inclusive perspective, needs transformation, awareness of the historical aspects and critical reflection on the history of exclusion to enable resistance and permanent search for human rights and inclusion.
The Kray Twins of East London
Authors: Velich Andrea
Published: July 2023

The paper addresses the thin line between the world of criminals and celebrities. It focuses on questions how role models and their media representation as well as biographies, memoirs, and their film adaptations have created and kept up the image of gangsters, more specifically, the infamy of the two East London criminals, Reggie and Ronnie Kray since the 1950s. After an introduction to aspects of organised crime, mafia, and a few examples of famous gangsters and the role models of the Kray twins from American Al Capone and Frank Sinatra to the English gangster Billy Hill, the paper highlights the life, representation, and image-making methods of the Krays in postwar London until they died in prison (Ronnie in 1995 and Reggie in 2000) as well as their strange, ever-growing popularity and fame even 20 years after their death. The author argues and aims to prove that the systematically built and promoted Kray brand and their legend served as the forerunner to and paved the success of the 2015 American blockbuster under the same title, Legend, and further documentary films and biopics on the Kray twins ever since.
GAYA KEPEMIMPINAN KEPALA SEKOLAH DALAM PENINGKATAN KINERJA GURU SD DI KECAMATAN BANYUASIN III
Authors: Arwan Arwan , Maryanti Ika Sefni
Published: July 2023

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan penerapan gaya kepemimpinan kepala sekolah dalam memperbaiki kinerja guru sekolah dasar di Kecamatan Banyuasin III Kabupaten Banyuasin. Sumber data penelitian ini adalah Kepala Sekolah sebanyak 3 orang  dan Guru sebanyak 9 orang. Penelitian ini menggunakan metode kualitatif. Teknik pengumpulan data dilakukan melalui wawacara, observasi dan Dokumentasi. Teknik analisis data dilakukan melalui reduksi data, penyajian data dan kesimpulan/verifikasi data. Hasil penelitian menjelaskan bahwa gaya kepemimpinan yang diterapkan oleh kepala sekolah yang berkaitan dengan kinerja guru di Kecamatan Banyuasin III Kabupaten Banyuasin yaitu gaya instruksi, gaya partisipatif, gaya delegasi dan gaya konsultif yang disesuaikan dengan kondisi dan lingkungan dimana kepala sekolah bertugas. Kinerja guru di Kecamatan Banyuasin III Kabupaten Banyuasin meningkat seiring dengan kemampuan kepala sekolah menerapkan berdasarkan gaya kepemimpinan tersebut.
PENYULUHAN TERKAIT KESESUAIAN DONOR PADA MASYARAKAT DI LINGKUNGAN PATTITANGNGANG, KECAMATAN MAPPAKASUNGGU, KAB. TAKALAR
Authors: Dahniar  , Akram Sitti Rahbiah
Published: July 2023

Transfusi darah adalah prosedur menyalurkan darah ke dalam tubuh seseorang yang kekurangan darah atau dalam suatu tindakan medis. Banyaknya masyarakat yang belum mengetahui manfaat dari pentingnya mendonorkan darah. Kegiatan ini dilaksanakn di Lingkungan Pattitangngang, Kecamatan  Mappakasunggu, Kab. Takalar, Sulawesi Selatan dengan sasaran kegiatannya yaitu Masyarakat setempat. Kegiatan ini diawali dengan pemberian materi tentang pentingnya edukasi kesesuaian donor kepada masyarakat dilanjutkan dengan pemeriksaan Kesehatan. Dari hasil penyuluhan diperoleh bahwa banyak masyarakat  yang belum mengetahui pentingnya edukasi masyarakat tentang kesesuaian donor dan jenis golongan darah masing-masing, sehingga dilanjutkan dengan pemeriksaan golongan darah. Sebanyak 29 peserta telah melakukan pemeriksaan golongan darah. Mayoritas Masyarakat di Lingungan Pattitangngang memiliki Golongan darah A, dan minoritas golongan darah AB. Berdasarkan hasil dari kegiatan ini, disimpulkan bahwa adanya peningkatan pengetahuan dan pemahaman pentingnya melakukan edukasi masyarakat tentang kesesuaian donor serta masyarakat dapat mengetahui jenis golongan darahnya masing-masing.
Exposición a plaguicidas en Latinoamérica: Revisión Bibliográfica
Authors: Castillo Belinda Bárbara , Mejía Dueñas Carlos Abraham
Published: July 2023

Introducción: Se estima que el uso de plaguicidas en los países de Latinoamérica y el Caribe representa alrededor del 20 % del consumo mundial y que en Centroamérica el consumo per cápita de plaguicidas es mucho mayor que en otras regiones del mundo (1.84 kg por persona/por año). Metodología: Se realizó una búsqueda de artículos, hasta 2023, incluyéndose algunos que fueron publicados en 1978, utilizando las palabras clave y sus combinaciones: plaguicidas, legislación y jurisprudencia, exposición a plaguicidas, uso de plaguicidas, salud ambiental, políticas públicas de salud, América Latina. Resultados: Las publicaciones sobre el uso, marco legal y efectos en la salud de los plaguicidas en América Latina son escasas, por lo que se trabajó sobre la base de 50 artículos, que se consideraron los más relevantes. Conclusión: A pesar de existir diferentes leyes, políticas y tratados, hoy día las estadísticas de prevalencia y regulaciones de uso están lejos de ser satisfactorias, lo que conlleva la necesidad que se determinen intervenciones acertadas y oportunas para minimizar los daños a la salud y al ambiente relacionados con plaguicidas.