bluuebunny/crossref_metadata_2025 huggingface dataset:
O OLHAR DO AGENTE COMUNITÁRIO DE SAÚDE PARA A SUA PRÁTICA PROFISSIONAL: ENTRE O TRABALHO REAL E O TRABALHO PRESCRITO
Authors: Dias Monique Nunes Fiuza
Published: October 2023

Neste artigo apresento as atribuições do Agente Comunitário de Saúde (ACS) em seu trabalho real e prescrito sob a ótica do próprio profissional, e o valor que lhes atribui. Optou-se por um estudo qualitativo que analisou dados primários. Constatou-se que o trabalho real destoa do prescrito. Entre as atribuições, aquelas que envolvem a presença no território e participação em grupos de educação em saúde, são valorizadas pelo ACS. Mesmo após constantes reformulações direcionadas ao cargo, o ACS valoriza as suas raízes, enquanto promotores de saúde.
Palavra-chave: Atenção Primária à Saúde; Agente Comunitário de Saúde; Trabalho em saúde.
A EDUCAÇÃO AMBIENTAL CRÍTICA EM PESSOA: ENTREVISTA COM CARLOS FREDERICO LOUREIRO
Authors: Maia do Bomfim Alexandre , Pereira do Nascimento Patrícia Maria , Rodrigues de Souza Juliana
Published: October 2023

Nosso entrevistado é Carlos Frederico Bernardo Loureiro, com certeza uma das principais referências em Educação Ambiental Crítica do país.  Loureiro é professor titular da Faculdade de Educação da Universidade Federal do Rio de Janeiro, professor do Programa de Pós-Graduação em Educação (PPGE) da UFRJ. Líder do Laboratório de Investigações em Educação, Ambiente e Sociedade (LIEAS/UFRJ). Foram suas graduações pela UFRJ (seu Bacharelado em Ecologia e Licenciatura em Ciências Físicas e Biológicas) que o levaram à Educação Ambiental, mas certamente foi seu percurso acadêmico posterior, seu percurso como pesquisador, assim como suas atividades profissionais e inclusive sua militância, que o conduziram para uma postura ainda mais crítica, para uma práxis sociológica-filosófica-política. Além de ser muito lido, Loureiro é formador de muitos formadores. Busca apreender a problemática ambiental, trazendo relevantes contribuições para processos educativos que se contraponham às respostas e soluções apregoadas pela educação hegemônica capitalista
A LUTA DOS TRABALHADORES É A LUTA AMBIENTAL E VICE-VERSA: ENTREVISTA COM DERCY TELES
Authors: Maia do Bomfim Alexandre , Da Silva Oliveira Thiago , Rodrigues de Souza Juliana
Published: October 2023

Nossa entrevistada é Dercy Teles, seringueira, primeira mulher a presidir um Sindicato de Trabalhadores Rurais na Amazônia, exatamente o mesmo sindicato que seria liderado depois por Chico Mendes. Antes da presidência e martírio de Chico, era ela quem liderava os trabalhadores rurais em Xapuri-Acre. Sua formação política se deu no interior das Comunidades Eclesiais de Base, influenciada pela Teologia da Libertação da Igreja Católica. O mandato de Dercy no Sindicato iniciou em 1981, ainda sob o Regime Militar e conforme suas próprias palavras, esteve sob “duas ditaduras: a ditadura militar e a ditadura dos camaradas homens”. A força de Dercy não deve ser registrada só nesse passado relativamente remoto, porque ela continuou militando e refletindo a situação dos trabalhadores por muito tempo, especialmente com esses que ficaram, assim como ela, nas “colocações” e na própria Reserva Extrativista Chico Mendes. A Dercy ainda tem muito a nos dizer e vai nos dizendo; ouvi-la é mexer também com nossas próprias convicções políticas.
A “QUESTÃO AMBIENTAL” NA OBTENÇÃO DA HEGEMONIA E O COMPROMISSO ÉTICO-POLÍTICO DOS EDUCADORES
Authors: Vasquinho Siqueira Thiago
Published: October 2023

O artigo aborda a apropriação da “questão ambiental” como artifício de obtenção do consenso sobre a concepção burguesa de mundo. Sua apreensão como especificidade social historicamente determinada deve buscar transcender a lógica instrumental criada pelo projeto de hegemonia burguesa, cabendo, especialmente aos educadores, apreender a totalidade determinada nas discussões da temática, possibilitando sua abordagem pelo compromisso ético-político com sua classe fundamental.
Palavras-chave: Questão ambiental; Hegemonia; Educação.
“EDUCAÇÃO PARA PERMANECER NO TERRITÓRIO”: A LUTA DOS POVOS CAIÇARAS FRENTE À EXPANSÃO DO CAPITAL EM PARATY-RJ
Authors: Marcondes de Souza Vanessa
Published: October 2023

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Editorial
Authors: Tiriba Lia , Botelho Jacqueline , Argüelles da Costa Regis , Morais Sandra , Aquino Mahalia
Published: October 2023

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Measurement of the Spatiotemporal Disparities in the Equalization Level of Basic Medical and Health Services in China: An Empirical Study Based on Provincial Panel
Authors: Fan Hailong , Wei Haibin
Published: October 2023

AbstractObjective This study aims to explore the
spatiotemporal disparities in the equalization of basic medical and
health services in China, in order to provide reference and guidance for
promoting the equalization process of basic medical and health services
and ensuring the fair enjoyment of citizens’ right to life and health.
Methods Based on the theory of Structure-Process-Outcome(SPO),
a comprehensive evaluation index system of equalization level was
constructed with 22 core indicators of basic medical and health
services, from the three dimensions of medical and health investment,
health service utilization, and medical service effectiveness. The
Generalized Principal Component Analysis (GPCA) model was used to
calculate the equalization level of basic medical and health services in
31 provinces, municipalities, and autonomous regions from 2011 to 2021.
Furthermore, the kernel density estimation and Moran’s I model was
employed to analyze the correlation and disparity at the spatial level.
Results 1. From a national perspective, the level of
equalization of basic medical and health services in China has
significantly improved from 2011 to 2021. The mean score of national
equalization level increased from -0.605 to 0.174, with an increase of
128.75%.
Involvement of Escherichia coli YbeX/CorC in ribosomal metabolism
Authors: Sarıgül İsmail , Žukova Amata , Alparslan Emel , Remm Sille , Pihlak Margus , Kaldalu Niilo , Tenson Tanel , Maiväli Ülo
Published: October 2023

YbeX of Escherichia coli, a member of the CorC protein family, is
encoded in the same operon with ribosome-associated proteins YbeY and
YbeZ. Here, we report the involvement of YbeX in ribosomal metabolism.
The ΔybeX cells accumulate distinct 16S rRNA degradation
intermediates in the 30S particles and the 70S ribosomes. E. coli
lacking ybeX has a lengthened lag phase upon outgrowth from the
stationary phase. This growth phenotype is heterogeneous at the
individual cell level and especially prominent under low extracellular
magnesium levels. The ΔybeX strain is sensitive to elevated
growth temperatures and to several ribosome-targeting antibiotics that
have in common the ability to induce the cold shock response in E.
coli. Although generally milder, the phenotypes of the ΔybeX
mutant overlap with those caused by ybeY deletion. A genetic
screen revealed partial compensation of the ΔybeX growth
phenotype by the overexpression of YbeY. These findings indicate an
interconnectedness amongst the ybeZYX operon genes, highlighting
their roles in ribosomal assembly and/or degradation.
Coronene Doped Ultra--Long RTP Polymers with Visible Light Excitability in Air
Authors: Liu Guanyu , Chen Junwu , Zhang Shiguo , Zhang Yuefa , Xue Shanfeng , Sun Qikun , Yang Wenjun
Published: October 2023

Abstract: It is emphasized that hetero- and heavy-atoms and specific
inter-molecular interactions are essential for ultra-long organic room
temperature phosphorescence (RTP), moreover, the RTP production
dominantly requires high-energy UV light excitation. In the current
work, we present that coronene (Cor) doped PMMA and PS can all emit
bright and ultra-long RTP with lifetimes of 4.43 and 2.97 s in air under
365 nm light excitation, respectively. More significantly, it is first
found that both Cor/PMMA and Cor/PS exhibit rare visible light
excitability up to 500 nm, and their afterglows are naked-eye visible
and the RTP lifetimes are up to 2.46 and 2.11 s under 440 nm light
excitation, respectively. However, hetero- and heavy-atom-free Cor has
neither common spin-orbital coupling nor visible light absorption band
in polymer film, and Cor/PS is a full hydrocarbon system. Therefore, we
propose that the multi-resonance effect and largely fused  systems are
responsible for the abundant triplet population and the visible light
excitability, signifying the significant enhancement of direct S0‒T1
transition. This work demonstrates a fresh RTP material system and
phenomenon and provides a new perspective of understanding organic
triplet generation and radiation.
Impact of Hospital International Health Services on Medical Tourism: A Review of Private Lebanese Hospitals’ Online Services and its Readiness to be Part of a National Medical Tourism Plan
Authors: Sweidy Charbel , Abou-Abbas Linda
Published: October 2023

Background: The phenomenon of medical tourism, rooted in ancient traditions and thriving in the modern world, has transformed into a robust global industry. Lebanon's private healthcare sector has historically attracted international patients, but it faces challenges such as communication barriers and evolving economic landscapes. This research delves into Lebanon's private healthcare sector, aiming to identify obstacles and propose strategies for effective International Health Services (IHS). 
Methods: Employing a descriptive methodology, this study evaluates 44 private hospital websites in Lebanon across dimensions like accessibility, institutional credentials, and communication standards. Healthcare management experts conducted the assessment, leading to the categorization of websites into informative, communicative, collaborative, and empowered tiers. Statistical analysis ensured the reliability of the reviewers' ratings, revealing consistent findings. 
Results: The assessment highlighted varying approaches among Lebanese private hospitals in catering to medical tourists. While most websites emphasize medical services, crucial information such as staff credentials and cost-related details often remain undisclosed. The study uncovered gaps in services like medical record transfers and post-treatment care. However, some hospitals proactively engage international patients, showcasing specialized expertise.
Conclusion: This research not only evaluates private hospital websites in Lebanon but also proposes an innovative IHS framework. This framework envisions an independent department, an online platform for telemedicine and appointment booking, and tailored marketing strategies. Implementing these components can bolster Lebanon's position in global medical tourism, fostering economic growth, enhancing healthcare services, and strengthening diplomatic relations. Strategic collaborations and the adoption of these proposed strategies can elevate Lebanon's private hospitals, contributing significantly to the healthcare system and the economy.
Analysis of the Benefits of Providing Credit to Micro dan Small Agricultural Businesses in Banjar Regency, Indonesia
Authors: Yuniar Norma , Yanti Nuri Dewi , Hamdani
Published: October 2023

Micro and Small Enterprises (MSEs) have an important and strategic role in the national economy. MSEs have received considerable attention from various groups, both from the government and financial institutions because they have proven to be part of the savior of the national economy which was experiencing a downturn at that time. The government and financial institutions have made various efforts to support the progress of MSEs, one of which is by providing business capital loans. Therefore, it is necessary to analyze the benefits of providing capital loans to MSEs. The research aims to: [1] analyze the benefits of credit that has been distributed by PT BPR Martapura Banjar Sejahtera and [2] analyze the factors that influence the decision of micro and small enterprises MSEs in agriculture to take credit at PT BPR Martapura Banjar Sejahtera. The data analysis method used in this research is quantitative descriptive analysis. The sampling method used is proportionate random sampling and accidental sampling. Data were analyzed through: [1] descriptive, [2] scoring method, and [3] tested through binary logistic regression. The results showed that the credit channeled by PT BPR Martapura Banjar Sejahtera to agricultural MSEs in Banjar Regency is effective in increasing the turnover of MSEs. It is also known that the variables of business risk and credit socialization are variables that significantly influence the decision of micro and small enterprises of MSEs in agriculture to take credit at PT BPR Martapura Banjar Sejahtera.
A Randomized, Clinical Trial Comparing the Efficacy of a Fascia Release Technique for the Treatment of Acute Ankle Sprains
Authors: Salo David , Johnson Anna Beth , Pandey Devansh , Pierce Jonathan , Eskin Barnet , Silverman Michael , Paley Lev
Published: October 2023

Acute ankle sprains are treated with ice, elevation, immobilization, and non-steroidal anti-inflammatory drugs. Resolution typically takes days. Osteopathic physicians utilize manipulation for a variety of joint disorders and injuries. Few have been studied in randomized controlled trials and many allopathic physicians are unaware of their utility. One manipulation, a modified muscle energy release technique, appears to offer promise for the treatment of acute ankle injuries, potentially returning patients to function more quickly than standard treatment alone. This study involved a comparison of a modified muscle energy release technique with standard treatment to standard treatment alone in the emergency department (ED) setting for patients with acute ankle injuries. This is an IRB approved, randomized single-blind sham-controlled study on a convenience sample of ED patients with pain from acute inversion injury. The study was set in a suburban ED with a 3-year Emergency Medicine Residency and an annual volume of 80,000. Inclusion criteria were patients aged 18-55 years; a Grade I or II acute ankle sprain less than 48 hours old; initial VAS scores ≥ 35; and being able to take 4 steps in the ED. We excluded fractures and Grade III injuries. The experimental manipulation technique involved placing the ankle into position of injury (inversion) for over 90 seconds and then bringing the ankle back to a neutral position over 90 seconds against mild hand resistance. The sham manipulation was similar but with plantar-flexion manipulation instead Patients were evaluated pre and 5 minutes after manipulation and 2 days later with a 100mm VAS pain scale completed by the patient after taking 4 steps. 17 patients were enrolled, 7 in the experimental (E) and 10 in the sham (S) group; 7 (41%) were female. There was no difference between groups for age (E=32; S=32 years p=0.9), gender (p=0.9), time from injury (E=7 vs S=11 hours; p=0.4) or initial VAS (E= 51 mm (SD 27); S= 57 mm (SD 20) (p=0.7). Both groups had similar distributions of pain (see schematic). There was no difference in mean pain relief between groups immediately after manipulation E=2.4mm (-11.0-15.88, 95%CI) vs S= 7.2mm (0.08-14.8, 95%CI) (p=0.4) or 2 days later E=29.1mm 1mm (8.5-49.7, 95%CI) S=26 (7.7 95%CI (p=0.8). Muscle energy release for acute ankle sprain does not improve pain immediately or in 2 days compared to standard treatment.
Gravitoelectromagnetic Field Strength Tensor in Flat Spacetime Frame: Dynamics of a Gyroscope in the Earth’s Gravitational Field
Authors: Kibande Wellingtone , Omolo Akeyo Joseph , Simiyu Wamalwa Dismas
Published: October 2023

In this article, we develop gravitoelectromagnetism (GEM) as a formal relativistic theory of gravitation characterized by a field potential fourvector in a flat (Minkowski) spacetime frame. By reorganizing the Lense-Thirring spacetime metric of linearized general relativity, we have determined the appropriate field potential four-vector and the field strength tensor which generates dynamics in the GEM field. The general covariant equation of motion of the spin four-vector of a gyroscope driven by the GEM field strength tensor provides the expected form of the frame-dragging and geodetic effects after introducing a gyromagnetic ratio η = 4 as an internal dynamical property of the gyroscope.
A construção do “ser professor” de Educação Física de docentes em início de carreira da rede municipal de Florianópolis-SC/Brasil
Authors: Ávila Diúlia , Backes Ana Flávia , Paludett Flores Patric , Breschiliare Fabiane Castilho Teixeira
Published: October 2023

Este estudo qualitativo analisou o processo de construção do “ser professor” de cinco docentes de Educação Física em início de carreira da rede municipal de Florianópolis, Santa Catarina, Brasil. Como fonte de dados, empregou-se uma entrevista semiestruturada, e a categorização dos resultados ocorreu por meio da análise de conteúdo. Os resultados evidenciaram que as experiências vivenciadas antes, durante e após a graduação são indispensáveis para o desempenho cotidiano do exercício docente. No que se refere à decisão pela Educação Física, o desejo pela docência, as experiências oferecidas pelo ambiente escolar, o gosto pelo esporte e as influências de professores e familiares são aspectos que se destacam. Já a escolha pela licenciatura considerou a intencionalidade dos professores, as trocas de experiências e a falta de clareza sobre as especificidades do curso. Relativamente às contribuições da formação inicial, foram salientadas a relevância do envolvimento com pesquisa e extensão, as experiências do estágio supervisionado e as trocas com professores do curso. O distanciamento do “chão da escola” e a frágil articulação com a licenciatura foram as principais lacunas evidenciadas. Conclui-se que a construção do “ser professor” é um processo contínuo, dinâmico, carregado de incertezas, de desafios, mas também repleto de muitos aprendizados. Como parte desse processo, é fundamental que as experiências formativas colaborem para a compreensão de que o docente é um ser intelectual.
Dossiê Paulo Freire: Um projeto-piloto de alfabetização de adultos – de Brasília para o Brasil
Authors: Moraes Raquel de Almeida , Waisros Pereira Eva , Taunay Maria Paula Vasconcelos
Published: October 2023

O presente artigo resulta de investigação relativa à experiência de alfabetização de adultos realizada em Brasília nos seus primórdios. Iniciada em 1963, sob a coordenação de Paulo Freire, essa experiência constituiu o embrião do Programa Nacional de Alfabetização (PNA), proposto pelo governo João Goulart. A pesquisa que serve de base para este estudo se desenvolveu mediante análise documental, orientada pela concepção crítica do método historiográfico. Os dados obtidos dialogam com os coletados no “Dossiê Paulo Freire”, concedido pela professora Maria de Souza Duarte ao acervo do Museu da Educação do Distrito Federal. Esse dossiê é composto por uma coleção de fotografias dos primeiros círculos de cultura em Brasília, bem como de reuniões das autoridades, de âmbito federal, responsáveis pelo PNA, além de documentos textuais relacionados ao objeto investigado. A riqueza de dados encontrados sobre Paulo Freire demonstra a importância de sua passagem pela nova capital e o caráter emancipador do projeto de alfabetização. A abrupta interrupção da experiência, pelo golpe de 1964, impediu a continuidade das políticas públicas de alfabetização de adultos em curso no Brasil e impôs o apagamento da presença do educador na capital do País durante a Ditadura Militar.
Urupā Tautaiao: Revitalising ancient customs and practices for the modern world
Authors: McNeill Hinamatau , Mortensen Steagall Marcos
Published: October 2023

Supported by the Marsden Fund Council from Government funding, managed by Royal Society Te Apārangi, this urupā tautaiao (natural burials) research has an explicit decolonising agenda. It presents a pragmatic opportunity for Māori to re-evaluate, reconnect, and adapt ancient customs and practices for the modern world. The design practice output focus is the restoration of existing graves located in the urupā (burial ground) of the Ngāti Moko, a hapū (subtribe) of the Tapuika tribe that occupy ancestral land in central North Island of New Zealand. In preparation for the gravesite development, a series of hui a hapū (tribal meetings) were held to engage and encourage participation in the research. The tribe drew on the expertise of an ecologist landscape architect and tohunga whakairo (master carver/artist) to transform the graves into a work of art. Surrounded by conventional gravestones, and using only natural materials, the gravesite aspires to capture the beauty of nature embellished with distinctively Māori cultural motifs. Low maintenance native plants are intersected with three pou (traditional carvings) that carry pūrākau (Māori sacred narratives) of life and death.
Editorial
Authors: Mortensen Steagall Marcos
Published: October 2023

Welcome to the first edition of the LINK Praxis Practice-led Design Research and Global South Journal. Established as an open-access academic journal, LINK Praxis aims to foster critical and innovative thought on practice-led design research practices emanating from the Global South. By bridging practice with academic integrity, we are committed to publishing high-quality, peerreviewed work centred on novelty, soundness, impact, and ethics. In our inaugural issue, we present ten articles that highlight the significance of practice as both an inquiry mode and a result of scholarly research, positioned from Aotearoa New Zealand. This edition celebrates a diverse range of contributors: eight Māori, one Pasifika, and two South American researchers who have collaborated closely with Māori counterparts. Journeying through this volume, readers are invited to engage with the multifaceted layers of Indigenous thought — from the realms of filmmaking and photography to the art of storytelling and performance. Each narrative provides a perspective into Global South’s and the use of creative practice as a methodological approach to scholarly research. The issue serves as an homage to the trailblazers – those who, through innovation and critical thinking, are reshaping the contours of design research with relationships with indigenous knowledge. We invite you to embrace the inevitable metamorphoses, challenges, and prospects that lie on the horizon, working to mould a design future that harmonises ancestral sagacity with design practice.
Bridging Binaries: Navigating Bicultural Space in Film Design
Authors: Ings Welby , Mortensen Steagall Marcos
Published: October 2023

This article examines how a researcher (a filmmaker whose lineage is both Indigenous and European) navigates ‘betweenness’ that is sometimes disruptive to cultural conventions. As a gay man who identifies as bicultural, I orient myself with, within and across worlds. From this position my approaches are largely shaped by the Māori values of manaakitanga (caring for the needs of people), kaitiakitanga (protecting and caring for all creation) and whanaungatanga (creating and sustaining relationships). These are supplemented by values emanating from my position as a gay activist and the resulting concerns with social justice and facing down the erasure, marginalization or exoticization of LGBTQ+ identities.  Although I am of mixed race ancestry, I see my bicultural positioning as a way of accessing a form of epistemological pluralism that embraces intellectual, physical, social and spiritual ways of knowing. Thus, when creating the feature film Punch (Ings, 2022), it was necessary to find a place to stand, in practice, as a bicultural story designer. This involved actualizing productive care inside how the film production was experienced, working in communion with the land as a living being, and navigating tensions of transgression by establishing facilities for cultural guidance and insight within the project.
Improving Efficiency of Corn Seed Separation and Calibration Process
Authors: Bredykhin Vadym , Tikunov Stanislav , Slipchenko Maksym , Alfyorov Oleksiy , Bogomolov Alexey , Shchur Taras , Kocira Sławomir , Kiczorowski Piotr , Paslavskyy Rostysav
Published: October 2023

The paper analyzes the existing theoretical research of corn seed separation and calibration processes. The machines, tools and equipment that implement the process were studied. An innovative sieve with openings in the Cassini oval shape was proposed for the economical separation and calibration of corn seeds. The results of operation of the proposed sieve in the operating conditions of Kharkiv Feed Mill on BSH-100 serial separators were considered. The study of the effectiveness of sifting corn seeds through the holes of the sieves was carried out in partnership with the State University “Ukrainian Research Institute of Forecasting and Testing of Agricultural Production Techniques and Technologies named after Leonid Pohorily” (Kharkiv Branch). The use of sieves with openings in the Cassini oval shape, instead of classic circular base openings, was found to result in an increase in throughput capacity of the sieve and open area of up to 20%.
Reducing the Probability of Failure in Manufacturing Equipment by Quantitative FTA Analysis
Authors: Bujna Marián , Prístavka Miroslav , Lee Chia Kuang , Borusiewicz Andrzej , Samociuk Waldemar , Beloev Ivan , Malaga-Toboła Urszula
Published: October 2023

Fault Tree Analysis (FTA) is a method that directly focuses on the modes of failures. The FTA is a graphical representation of the major faults or critical failures associated with a product, as well as the causes for the faults and potential countermeasures. The aim of this research paper is to calculate the probability of the top event – the failure of the process using FTA and propose a technique to prioritize factors for action design and reduce the likelihood of a top event failure based on manufacturers' requirements. We have constructed a qualitative fault tree to produce office components packed and sealed in blister packs using a KOCH KBS-PL machine. We defined the top event G – the production of office components, packed and sealed in blister packs on the machinery KOCH KBS-PL. Then we defined events leading to top events down to individual failure factors. Based on the links between the fault tree and the probability of failure, we performed a quantitative analysis to determine the probability of failure of individual events. We found out that the probability of failure of G is 5.04%. Subsequently, we identified which factors most significantly reduce the resulting probability of failure of factor G. These are the factors: E – feed rate, F – cooling, AL – incorrect setting and D – break. It has been proven that by controlling these 4 factors, we can reduce the probability of failure of top event G to 2.36%, provided that effective measures are taken. The final proposal meets the requirements of several manufacturers for a fast, efficient, and cost-effective solution. We have created a proposal that saves time, has minimal software and hardware requirements, and is easy to use. The efficiency and effectiveness of the proposal was that we identified the weakest points in the fault tree that most significantly cause the top event to fail. This prioritized the factors for the design of the measures.
Chemical and Energetical Properties in Methane Fermentation of Morphological Parts of Corn with Different Variety Earliness Standard FAO
Authors: Wojcieszak Dawid , Pawłowski Artur , Dammer Karl-Heinz , Przybył Jacek
Published: October 2023

In the last decades, the production of biomass biofuels for thermochemical conversion to replace fossil fuels has attracted increasing attention as it offers significant environmental benefits. A very common way to convert biomass to energy is methane fermentation. The importance of biogas as a source of energy is growing. The use of biomass to biogas production on a large, global scale may lead to controversial competition for arable land, water, and consequently, food. Therefore, only waste materials and agricultural by-products and residues should be used for biogas production. Corn stover is a good example of agricultural residues for biogas production. Therefore, the aim of these studies was to determine the influence of corn variety earliness FAO on the chemical compositions and energy value of morphological parts (fractions) of corn plants. The research material consisted of morphological parts of corn plants: stalks, leaves, husks, and cobs of selected corn cultivars, differing in terms of their FAO earliness: early (FAO 220), medium-early q(FAO 240) and late (FAO 300) varieties. The research included laboratory investigations, elemental analysis, methane fermentation and statistical analyses of results. Based on the results of the study, it was concluded that the FAO earliness of a corn variety had a significant impact on the elemental composition, ash content, biogas, and methane yield in the corn morphological fractions. The highest methane yield of 267.4 m3·Mg−1 TS was found for the cucurbit cover leaves of a variety with an FAO 240 earliness standard.
Updated insights into predictive biomarkers for response to cardiac resynchronization therapy - A literature review
Authors: Pal Krisztina , Cotoi Ionela M. , Vlad Georgiana G. , Lupu Silvia
Published: October 2023

Cardiac resynchronization therapy (CRT) was shown to greatly improve outcomes in specific patients with heart failure, low ejection fraction and wide QRS complex; however post-therapeutic response is heterogeneous and currently difficult to predict. There is an increasing interest in identifying humoral biomarkers which could help stratify prognosis, and better identify responders. The aim of this review was to provide an overview of recent data regarding the predictive value of biomarkers for evaluating response to CRT. A definitive conclusion cannot currently be drawn due to disparate results, varying methodologies, relatively small-scale studies and lack of consensus in defining CRT response. More extensive comparable research is paramount to facilitate progress in this field.
Molecular and clinical aspects of HNSCC in the Republic of Moldova
Authors: Stratan Valentina , Țuțuianu Valeri , Sîtnic Victor , Popa Cristina , Balan Veronica , Clipca Adrian , Sclifos Ina , Monastirscaia Anastasia , Trohin Victoria , Sprincean Mariana
Published: October 2023

Introduction: Complex molecular characterization and integrated approaches in the basic research of HNSCC provide new insights into the understanding and treatment of these tumors. Mutations in the TP53 gene, HPV infection, aberrant DNA methylation are just a few factors that have a direct link with the clinical and psychological condition of patients with this type of cancer. In the Republic of Moldova, these aspects are insufficiently studied.

Methods: The study included 128 patients with HNSCC from whom the following samples were collected: fresh tumor tissue, NAT, blood, and saliva. All samples, except saliva, were tested for 3 mutations in the TP53 gene, while DNA isolated from tumor tissue was also tested for global DNA methylation assessment. HPV genotypes were tested from saliva. HPV positive samples were retested from tumor tissue.

Results: Of the total analyzed samples for TP53 pathogenic variants, in 30 (23.44%) samples there were detected one or two mutations, and in 9 samples (7.03%) – it was detected the presence of two mutations simultaneously. HPV infection was detected in 17 samples (13.28%). Regarding global DNA methylation, in patients with a high degree of exposure to stress, a 44% lower level was observed (median 13.5 ng/ml) compared to those with moderate and low exposure (median 20.5 ng/ml ).

Conclusion: The most frequent mutation identified in the TP53 gene was the 524G>A substitution and the frequency of high-risk HPV infection in HNSCC patients from Moldova was 13.28%. The high degree of stress exposure showed a lower level of global methylation.
Associations of levels of high-molecular-weight adiponectin, secreted frizzled-related protein 5 and vascular endothelial growth factor-165 with diabetic retinopathy
Authors: Fu Yanfang , Ye Shizhen , Peng Jianjun
Published: October 2023

Background: The pathogenesis of diabetic retinopathy (DR) remains unclear. The aim of the study was to explore the associations of DR with the levels of high-molecular-weight adiponectin (HMW-ADP), secreted frizzled-related protein 5 (SFRP-5) as well as vascular endothelial growth factor-165 (VEGF165).

Methods: Based on the diagnostic criteria for DR, non-DR (NDR), proliferative DR (PDR) plus non-proliferative DR (NPDR) groups were set up for type 2 diabetes mellitus (T2DM) patients (n=180) treated from January 2020 to March 2021. The control group consisted of another 60 healthy subjects undergoing physical examinations. Their clinical data were compared. Receiver operating characteristic curves were plotted to assess the predictive values of HMW-ADP, VEGF165 and SFRP-5 for DR. The predictive efficiency of the established nomogram model was assessed.

Results: The differences in age, fasting plasma glucose (FPG), T2DM duration, triglyceride (TG), hypertension history, high-density lipoprotein cholesterol (HDL-C), glycosylated haemoglobin (HbA1c), serum creatinine (Scr), homeostasis model assessment of insulin resistance (HOMA-IR), urine acid (UA), SFRP-5 HMW-ADP, and VEGF165 were significant between control and DR groups (P<0.05). HMW-ADP, VEGF165 and SFRP-5 had predictive values for DR (AUC>0.7), and the predictive efficiency of their combination was highest. The duration of T2DM, Scr, UA and VEGF165 were independent risk factors for DR, while HMW-ADP and SFRP-5 were protective factors (P<0.05). Preferable discrimination and accuracy together with clinical applicability were obtained for the nomogram prediction model.

Conclusions: The three indicators as a whole have a high predictive value for DR, as potential indicators for the clinical screening of high-risk groups.
Proteomic patterns in glomerular research, a laser capture microdissection and liquid chromatography-tandem mass spectrometry approach
Authors: Bărar Andrada A. , Pralea Ioana E. , Berindan-Neagoe Ioana , Pirlog Radu , Nutu Andreea , Maslyennikov Yuriy , Potra Alina R. , Iuga Cristina A. , Kacso Ina M.
Published: October 2023

Introduction: Molecular techniques have the potential to shed light on glomerular diseases that conventional renal pathology may be unable to reveal. The aim of this study was to investigate whether proteomic patterns of glomeruli obtained from kidney biopsies can differentiate between minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS) and control groups (CTR).

Methods: 18 formalin-fixed, paraffin-embedded (FFPE) renal biopsies comprising three groups of samples (CTR=3, MCD=6, FSGS=9) were subjected to label-free quantitative mass spectrometry. Glomeruli were excised from FFPE renal biopsies by laser capture microdissection (LCM) and, to increase both yield and protein identifications, single-pot solid-phase-enhanced sample preparation (SP3) digest method was applied. The samples were analyzed by mass spectrometry based shotgun proteomics.

Results: The proteome profiling resulted in the identification of a total of 723 proteins. Multivariate analysis provided several proteins important in the separation of the three groups. Pattern Hunter analysis revealed moderate and high correlation of proteins against CTR-FSGS-MCD or CTR-MCD-FSGS patterns. The most significant pathways involved were associated with nephrin family and cytoskeleton interactions, as well as laminin/extracellular matrix related proteins. Univariate analysis revealed 58 significant different proteins among the three groups. Signaling pathways of these proteins were also associated with nephrin family interactions and cytoskeleton organization.

Conclusions: This study demonstrates that mass spectrometry-based shotgun proteomic analysis of LCM glomeruli yields reproducible and quantitative data capable of discriminating between different disease conditions. Differentially expressed proteins provide insights into pathogenesis of glomerular disease.
Correlations of special AT-rich sequence binding protein 2 and chitinase-3-like protein-1 with sensitivity to paclitaxel chemotherapy for gastric cancer
Authors: Zhuang Hesi , Huang Limin , Yang Zhengqi
Published: October 2023

Background: Our objective was to examine the associations between special AT-rich sequence binding protein 2 (SATB2) and chitinase-3-like protein-1 (CHI3L1) and the responsiveness to paclitaxel treatment in individuals with gastric cancer.

Methods: From March 2018 to October 2020, our hospital collected gastric cancer samples along with adjacent gastric mucosal tissues located more than 5 cm away from the cancerous margin. These samples were obtained from 90 patients who underwent chemotherapy regimens containing paclitaxel. To assess the rates of positive expression of CHI3L1 and SATB2 in gastric cancer and adjacent tissues, the immunohistochemical streptavidin-peroxidase (SP) technique was utilized.

Results: The positive expression rate of CHI3L1 was higher in gastric cancer tissues compared to adjacent tissues, while the positive expression rate of SATB2 was lower (P<0.05). Risk factors that influenced the positive expression of CHI3L1 in gastric cancer tissues included the level of differentiation, tumor-node-metastasis (TNM) stage, and the presence of lymph node metastasis (OR>1, P<0.05). Additionally, the positive expression of SATB2 was also affected by TNM stage and lymph node metastasis, which were identified as risk factors (OR>1, P<0.05). In gastric cancer tissues, there was a negative correlation observed between the expressions of CHI3L1 and SATB2 (r<0, P<0.05). According to the analysis results of Kendall’s tau-b (K), it was found that the presence of CHI3L1 had an inverse relationship with the responsiveness to paclitaxel-based chemotherapy in gastric cancer (r=-0.498, P=0.000), while SATB2 exhibited a positive correlation with the sensitivity (r=0.513, P=0.000). During the 3-year follow-up after chemotherapy, the survival rate was 55.55% (50/90).

Conclusions: The findings indicate a strong correlation between SATB2 and CHI3L1 with the TNM stage, lymph node metastasis, response to paclitaxel-based chemotherapy, and the overall survival rate of individuals.
Off-Shore and On-Shore Macroalgae Cultivation and Wild Harvesting: an LCA-Based Evaluation from Baltic Sea Region Case Studies
Authors: Paoli Riccardo , Bjarnason Bjarni , Ilmjärv Tanel , Romagnoli Francesco
Published: October 2023

Seaweeds are organisms with unique characteristics. They contain a broad spectrum of micro and macro elements (i.e., minerals, carbohydrates, proteins, lipids, pigments, and vitamins). Furthermore, they have a very high growth rate and are present in large quantities and species in nature. Therefore, they represent an ideal feedstock for a biorefinery concept. Historically, macroalgae used in biorefineries have been harvested directly from the sea or the shores, i.e., off-shore technique. However, recent studies are analysing the possibility of creating on-shore cultivation facilities. This research aims to perform a Life Cycle Assessment (LCA) study that analyses and compares the environmental impact of two seaweed cultivation and wild harvesting techniques in the Baltic Sea Region conditions based on existing pre-commercial and commercial projects. Inventory data are collected directly from two macroalgae producers, one off-shore and one on-shore, integrated with literature, and then normalized to the selected functional unit, i.e., 1 ton of harvested fresh macroalgae. The results, implemented with SimaPro 9.4 software, determine which of the two techniques has the highest environmental impact and which are the most sensitive environmental indicators. Furthermore, the results underline the critical parameters for the two cultivations (i.e., fuel consumption and electricity), contributing to identifying environmental benchmarks for further optimization strategies. The sensitivity analysis included in the study aims to explore and highlight the effect of the variation of selected input parameters or assumptions to provide a consistent assessment of the uncertainty of the model outputs and the main findings in terms of environmental impacts.
Research Trend of 21st Century Skills in Science Education Through Bibliometrics
Authors: Mulyani* Asep , Indriyanti Dyah Rini , Madnasri Sutikno
Published: October 2023

Science learning plays an important role in facilitating the development of 21st century skills. Scholars have paid much attention to the topic in their research activities to gain a comprehensive picture of its role in science education. This study aims to provide an overview of research trends on 21st century skills, especially in science education, through a search for articles that have been published since 2000-2022. The articles consisted of 740 articles derived from the scopus and google scholar databases through searches using the publish or perish search engine. Bibliometric network mapping using visualization of similarities. This bibliometric research is based on stages based on the preferred reporting items for systematic reviews and meta-analyses and network meta-analyses method or abbreviated as preferred reporting items for systematic reviews and meta-analyses. The results showed that 21st century skills research in recent years has increased and occurs at various levels of education and scientific discipline areas and uses a variety of research methods. The findings are expected to provide an overview for other researchers regarding 21st century skills including the number of publications, country of origin, type of publications, research methods, research subjects, types of instruments used, disciplinary fields (science, chemistry, physics, and biology), and learning interventions
Surgical Management of Vascular Trauma; A Systematic Review
Authors: Sersarh Mahmood , Alshaikh Abdulrahman , Alsalem Fatimah , Alatawi Kholoud , Almnjwami Rasan , Alanazi Rawan , Alomar Taif , Almahdi Rahf , ALotaibi Sultan , Allam Abdullah
Published: October 2023

Vascular trauma is a significant public health concern, and there have been numerous incidents globally in recent years. Peripheral vascular injuries, including axillobrachial and upper extremity branches, as well as femoropopliteal and lower limb branches, account for 40% to 75% of all vascular injuries. Our systemic review aimed to examine surgical management strategies for vascular trauma. Data sources included PubMed/Medline and Embase. Our review investigated English-language articles (from 2010 to 2023) according to the PRISMA guidelines. Overall, there were 7 articles. Surveys and analyses of national databases were the most widely used methods (n=7 studies). The search identified 777 studies, 7 were eligible for inclusion in the analysis. Further understanding of vascular trauma, and treatment protocols may help improve evaluation and management in the future. Our research covered a range of treatment options; the proportion of vascular injuries treated without surgery or utilizing endovascular techniques has increased. Individuals who receive medications intravenously, especially drug users, often present late in the course of their diseases and are notoriously difficult to treat. Despite the challenges in control, it is crucial to remain vigilant for vascular problems that might be fatal. Patient education and awareness may lead to the early detection and treatment of these diseases, which have high morbidity and mortality rates. Revascularization is necessary for limb salvage in patients with severe vascular damage. Simultaneous orthopedic injuries pose significant challenges and increase the risk of limb amputation. Multiple fractures and a MESS score of 6 indicate limited potential for limb salvage.
Use of Single Dose 940 nm diode Laser to Relief Facial Pain
Authors: Sh. Rajab Muthenna , Kh. Mohmmad Yasir , M. Talab Elias , S. Hamad Abdullah , A. Mahmod Talat , A Gh Alokaily Abrahim
Published: October 2023

Objective: the purpose of the study is to evaluate the effect of single high dose Epic x diode laser on several types of facial and dental pain. Methods: a total of 10 patients were diagnosed with orofacial pain, 8 of them were suffering from myofacial pain, while the other two patients, one of them had pulpitis and the other one was suffering from pericoronitis. The patients were treated using Epic x diode laser with the following settings (940 nm wavelength, 4 w, 1200J). Each patient was treated in a single session. The headpiece was directed toward the involved symptomatic area and the overall pain and discomfort were analyzed into a scale of six degrees including before and after the treatment.Results had 40% of the cases are with complete resolution of pain and 60% of the cases had partial improvement, and the sessions were delivered as a single session of 300 seconds irradiation for each patient and the degrees of improvement were (1,2,3) on the pain scale.Conclusion: Diode laser (Epic x) is effective in reducing the orofacial pain with single session treatment
A Review of Lip Print as A Tool in Forensic Dentistry
Authors: A. Anai Tamara , Abd Alhameed Sulaiman Adnan , Nader Hussein Yasir
Published: October 2023

Background: Forensic dentistry requires interdisciplinary knowledge since the data obtained from the oral cavity can contribute to identify an individual or provide the information needed in a legal process. Identification is a major problem facing forensic practitioners, DNA and fingerprints are highly useful but sometimes are not easily collected from the crime scene. Lip print could be useful in this field the lip prints are unique and distinguishable for every individual like fingerprints. The external surface of lips has many elevations and depressions forming a characteristic pattern called lip prints, examination of which is known as Cheiloscopy. However, there are many well-known implanted methods of human identification. Historical Background: The biological phenomenon of systems of grooves on the red part of human lips was first noted by anthropologists, Fischer was the first to describe it in 1902. The use of lip prints in personal identification was first recommended in France by Edmond Locard. Conclusion: This literature search covering a part of identifying a person using lip print, lip prints may also be used in detection work, being the source of criminalistic information. A lip print at the scene of a crime can be a basis for conclusions as to the character of the event, the number of the people involved, sexes, cosmetics used, habits, occupational traits, and the pathological changes of lips themselves.
Comparing and Evaluating the Effect of Different Thickness of Two Metal-Free Restoration on Fracture Resistance in Molar Implant Prosthesis
Authors: Jamal Harb Elaf , Mahdi Kanaan Sabiha
Published: October 2023

Aim: The objectives of this article was to determine the minimum thickness of two monolithic materials for a posterior implant prosthesis. Materials and methods sixty monolithic IPS E.MAX CAD and zirconia crowns with different occlusa l thicknesses were made with the use of a computer-aided design/computer-aided manufacturing technique was divided into 3 experimental groups: group (1) 0.5 mm group (2) 0.7mm group (3)1mm. A universal testing machine was used to determine the fracture load value. The restoration was loaded until fracture; the fracture resistance was registered. Two-way ANOVA has been used to examine the data., followed by the least significant difference LSD test. One-way ANOVA variance analysis was used to examine the differences in fracture load of monolithic zirconia or IPS E.MAX CAD at various thicknesses (p=0.05). Results vertical load test revealed that the fracture resistance of monolithic zirconia higher than the lithium disilicate crown (E.MAX CAD). The results showed that the highest mean value of fracture load test was obtained in the ice zirconia translucent with 1mm thickness group (1880N), while the lowest mean value was in the E.MAX CAD with thickness 0.5mm Group (223N). Conclusions: The fracture resistance of CAD-CAM monolithic crowns is influenced by the occlusal thickness. zirconia prosthesis with occlusal thickness 0.7mm,1mm had a high fracture resistance when compared with E.MAX CAD.