bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on prescribing cascades: a scoping review
Authors: Chen Zhe , Liu Zheng , Zeng Linan , Huang Liang , Zhang Lingli
Published: July 2023

Background: The concept of prescribing cascades has been proposed for more than 20 years, but the research progress and cognitive level varied in different countries. The aim of this study was to systematically evaluate the current status of relevant original research on prescribing cascades, and to provide references for further research and continuous improvement in clinical practice.

Methods: We searched three English databases and four Chinese databases from inception until January 2022. Relevant studies about prescribing cascades meeting the eligibility criteria were extracted independently by two reviewers, and a descriptive analysis was conducted to compare the methods and outcomes of the included studies.

Results: A total of 32 studies involving 7,075,200 patients in 11 countries were included, including 13 cross-sectional studies, 11 case reports, 7 cohort studies, and 1 case-control study. The target population was mainly elderly people (24 studies). The purpose of the included studies could be divided into three categories: prevention (4 studies), identification (17 studies), and resolution (11 studies) of prescribing cascades. 49 prescribing cascade routes were identified and mainly attributed to the cardiovascular system, most primary diseases of which were dementia, the initial medications of prescribing cascades were mainly calcium channel blockers, and two to six drugs were involved in the prescribing cascade routes.

Conclusion: Prescribing cascades have attracted more attention internationally and current studies have mainly focused on the elderly and their cardiovascular diseases and nervous diseases, but still not yet formed integral research in other special populations of drug use, such as children and pregnant women. It is necessary to further conduct in-depth studies with a broader range, and to establish a series of effective measures to decrease the incidence of prescribing cascades in the high-risk group of drug use.
Hyperactivity of medial prefrontal cortex pyramidal neurons occurs in a mouse model of early-stage Alzheimer’s disease without β-amyloid accumulation
Authors: Choudhury Nasreen , Chen Lihua , Al-Harthi Lena , Hu Xiu-Ti
Published: July 2023

The normal function of the medial prefrontal cortex (mPFC) is essential for regulating neurocognition, but it is disrupted in the early stages of Alzheimer’s disease (AD) before the accumulation of Aβ and the appearance of symptoms. Despite this, little is known about how the functional activity of medial prefrontal cortex pyramidal neurons changes as Alzheimer’s disease progresses during aging. We used electrophysiological techniques (patch-clamping) to assess the functional activity of medial prefrontal cortex pyramidal neurons in the brain of 3xTg-Alzheimer’s disease mice modeling early-stage Alzheimer’s disease without Aβ accumulation. Our results indicate that firing rate and the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were significantly increased in medial prefrontal cortex neurons from young Alzheimer’s disease mice (4–5-month, equivalent of <30-year-old humans) compared to age-matched control mice. Blocking ionotropic glutamatergic NMDA receptors, which regulate neuronal excitability and Ca2+ homeostasis, abolished this neuronal hyperactivity. There were no changes in Ca2+ influx through the voltage-gated Ca2+ channels (VGCCs) or inhibitory postsynaptic activity in medial prefrontal cortex neurons from young Alzheimer’s disease mice compared to controls. Additionally, acute exposure to Aβ42 potentiated medial prefrontal cortex neuronal hyperactivity in young Alzheimer’s disease mice but had no effects on controls. These findings indicate that the hyperactivity of medial prefrontal cortex pyramidal neurons at early-stage Alzheimer’s disease is induced by an abnormal increase in presynaptic glutamate release and postsynaptic NMDA receptor activity, which initiates neuronal Ca2+ dyshomeostasis. Additionally, because accumulated Aβ forms unconventional but functional Ca2+ channels in medial prefrontal cortex neurons in the late stage of Alzheimer’s disease, our study also suggests an exacerbated Ca2+ dyshomeostasis in medial prefrontal cortex pyramidal neurons following overactivation of such VGCCs.
Comparing the hemodynamic effect of a large arteriovenous fistula during high and low cardiac output states
Authors: Valerianova A. , Mlcek M. , Malik J. , Grus T. , Tejkl L. , Kolosova B. , Lejsek V. , Kittnar O.
Published: July 2023

Background: A large arteriovenous fistula (AVF) is a low-resistant circuit that affects organ perfusion and systemic hemodynamics even in standard conditions. The extent of its’ effect in critical states has not been elucidated yet. We used norepinephrine to create systemic vasoconstriction, dobutamine to create high cardiac output, and rapid right ventricle pacing as a model of acute heart failure in a porcine model of high-flow AVF circulation.

Methods: The protocol was performed on nine domestic female pigs under general anesthesia. AVF was created by connecting two high-diameter ECMO cannulas inserted in the femoral artery and vein. Continuous hemodynamic monitoring was performed throughout the protocol. Three interventions were performed–moderate dose of norepinephrine (0.25 ug/kg/min), moderate dose of dobutamine (10 ug/kg/min) and rapid right ventricle pacing to simulate low cardiac output state with mean arterial pressure under 60 mmHg. Measurements were taken with opened and closed arteriovenous fistula.

Results: Continuous infusion of norepinephrine with opened AVF significantly increased mean arterial pressure (+20%) and total cardiac output (CO) (+36%), but vascular resistance remained virtually unchanged. AVF flow (Qa) rise correlated with mean arterial pressure increase (+20%; R = 0.97, p = 0.0001). Effective cardiac output increased, leading to insignificant improvement in organ perfusion. Dobutamine substantially increased cardiac output with insignificant effect on AVF flow and mean arterial pressure. Carotid artery blood flow increased significantly after dobutamine infusion by approximately 30%, coronary flow velocity increased significantly only in closed AVF state. The effective cardiac output using the heart failure model leading to decrease of carotid artery flow and worsening of brain and peripheral tissue oximetry. AVF blood flow also dropped significantly and proportionally to pressure, but Qa/CO ratio did not change. Therefore, the effective cardiac output decreased.

Conclusion: In abovementioned extreme hemodynamic conditions the AVF flow was always directly proportional to systemic perfusion pressure. The ratio of shunt flow to cardiac output depended on systemic vascular resistance. These experiments highlight the detrimental role of a large AVF in these critical conditions’ models.
Effects of fermented soybean meal substitution for fish meal on intestinal flora and intestinal health in pearl gentian grouper
Authors: Pang Aobo , Peng Cong , Xie Ruitao , Wang Zhuoduo , Tan Beiping , Wang Tingting , Zhang Wei
Published: July 2023

This study explored the role of replacing fish meal protein with fermented soybean meal (FSBM) protein on the growth performance and intestinal morphology, immunity, and microbiota of the pearl gentian grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂). Three isonitrogenous and isolipidic diets with increasing levels of FSBM (0%, 20% and 40%; referred to as FM, FSBM20 and FSBM40 diets, respectively) as a replacement for fish meal were selected for this study. The pearl gentian grouper were fed these diets for 10 weeks. The findings revealed that the growth of fish fed the FSBM diets (FSBM20 and FSBM40) were remarkably lower than the fish fed the FM diet. Pathological manifestations of intestinal inflammation, such as shortened intestinal mucosal folds and thickened lamina propria, were observed in the fish fed the FSBM diets. Moreover, the gene expression levels of IL1β, IL12, IL17, and TNFα were remarkably upregulated in fish fed the FSBM40 diet, in contrast to the gene expression levels of IL4, IL5, IL10, and TGFβ1, which were remarkably downregulated (p < 0.05). The FSBM diets significantly affected the stability of the fish gut microbiota. Photobacterium was the dominant phylum in all experimental groups, and the proportion of these bacteria gradually decreased with increasing FSBM substitution. The composition of intestinal flora at the genus level was not the same in the three experimental groups, with a richer composition of intestinal bacteria detected in the FSBM20 and FSBM40 groups (p < 0.05). The correlation between intestinal flora balance and immune gene expression revealed that only Photobacterium was negatively correlated with the above upregulated genes, while other bacteria were positively correlated with these pro-inflammatory factors (p < 0.05). Photobacterium was positively correlated with the above downregulated genes, while other bacteria were negatively correlated with these anti-inflammatory factors (p < 0.05). In conclusion, high levels of substitution of FSBM for fish meal causes intestinal inflammation in pearl gentian grouper. This is likely associated with changes to the intestinal flora. More attention should be paid to the negative role of dietary FSBM on intestinal flora.
The role of ipsilateral motor network in upper limb movement
Authors: Ding Hao , Seusing Nelly , Nasseroleslami Bahman , Anwar Abdul Rauf , Strauss Sebastian , Lotze Martin , Grothe Matthias , Groppa Sergiu , Muthuraman Muthuraman
Published: July 2023

The execution of voluntary movements is primarily governed by the cerebral hemisphere contralateral to the moving limb. Previous research indicates that the ipsilateral motor network, comprising the primary motor cortex (M1), supplementary motor area (SMA), and premotor cortex (PM), plays a crucial role in the planning and execution of limb movements. However, the precise functions of this network and its interplay in different task contexts have yet to be fully understood. Twenty healthy right-handed participants (10 females, mean age 26.1 ± 4.6 years) underwent functional MRI scans while performing biceps brachii representations such as bilateral, unilateral flexion, and bilateral flexion-extension. Ipsilateral motor evoked potentials (iMEPs) were obtained from the identical set of participants in a prior study using transcranial magnetic stimulation (TMS) targeting M1 while employing the same motor tasks. The voxel time series was extracted based on the region of interest (M1, SMA, ventral PM and dorsal PM). Directed functinal connectivity was derived from the extracted time series using time-resolved partial directed coherence. We found increased connectivity from left-PMv to both sides M1, as well as right-PMv to both sides SMA, in unilateral flexion compared to bilateral flexion. Connectivity from left M1 to left-PMv, and left-SMA to right-PMd, also increased in both unilateral flexion and bilateral flexion-extension compared to bilateral flexion. However, connectivity between PMv and right-M1 to left-PMd decreased during bilateral flexion-extension compared to unilateral flexion. Additionally, during bilateral flexion-extension, the connectivity from right-M1 to right-SMA had a negative relationship with the area ratio of iMEP in the dominant side. Our results provide corroborating evidence for prior research suggesting that the ipsilateral motor network is implicated in the voluntary movements and underscores its involvement in cognitive processes such as movement planning and coordination. Moreover, ipsilateral connectivity from M1 to SMA on the dominant side can modulate the degree of ipsilateral M1 activation during bilateral antagonistic contraction.
Genome-wide identification of R-SNARE gene family in upland cotton and function analysis of GhVAMP72l response to drought stress
Authors: Li Bingxuan , Zhou Gen , Li Yanbin , Chen Xueting , Yang Huiting , Li Yan , Zhu Minhua , Li Libei
Published: July 2023

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) mainly promoted the assembly of the SNARE complex to drive the final membrane fusion step of membrane transport. Previous research on R-SNAREs has mainly focused on development and growth and has rarely been involved in abiotic stress, especially in cotton. Here, we performed a comprehensive analysis of R-SNARE genes in upland cotton. In total, 51 Gh-R-SNARE genes across six phylogenetic groups were unevenly distributed on 21 chromosomes. Cis elements related to plant growth and response to abiotic stress responses were found in the promoter region of Gh-R-SNAREs. Nine Gh-R-SNARE genes were obviously upregulated under drought stress conditions by RNA-seq and qRT–PCR analysis. Among them, GhVAMP72l might be the key candidate gene contributing to drought stress tolerance in cotton by virus-induced gene silencing (VIGS) assay. These results provide valuable insights for the functional analysis of cotton R-SNAREs in response to drought stress and highlight potential beneficial genes for genetic improvement and breeding in cotton.
Bayesian estimation for the random moderation model: effect size, coverage, power of test, and type І error
Authors: Wei Dan , Zhan Peida
Published: July 2023

The random moderation model (RMM) was developed based on a two-level regression model to cope with heteroscedasticity in moderation analysis, and normal-distributed-based maximum likelihood (NML) estimation was developed to estimate the RMM. To present an alternative to the NML, this article discusses the effectiveness of Bayesian estimation for the RMM, aiming to explore a more practical method using the popular software Mplus. Through a simulation study, the RMM based on Bayesian estimation was investigated and compared to maximum likelihood (ML) estimations, including the NML and the default ML estimation in Mplus. The results indicated that the Bayesian approach outperformed the two ML estimations. It showed (a) higher accuracy for estimation of the effect size of the moderation effect; (b) higher 95% credibility interval coverage of the true value of the moderation effect; and (c) well-controlled and more stable type I error rates, while powers comparable to the ML estimations were provided.
Improving disease management of patients with inflammatory bowel disease: the potential role of self-concordant health goals
Authors: Horvát Barbara , Dávid Anett , Sallay Viola , Rafael Beatrix , Njers Sanela , Orbán Kata , Molnár Tamás , Csabai Márta , Martos Tamás
Published: July 2023

Inflammatory bowel diseases (IBD) are chronic gastrointestinal conditions that significantly impact patients’ quality of life. Previous research indicates that patients with IBD have a higher prevalence of anxiety compared to the general population and other chronic diseases. This pilot study aimed to investigate the relationships between goal integration, positive and negative emotions, goal self-efficacy, and trait anxiety as the outcome variable, focusing on patients’ self-management strategies. Drawing from the Self-Concordance Model (SCM) of Self-Determination Theory (SDT), the study explored how goal integration is associated with more fulfilling and enjoyable experiences and fewer negative emotions, ultimately improving psychological well-being. Health-related goals were evaluated using the Personal Project Analysis technique, while the State–Trait Anxiety Inventory was utilized to measure general anxiety levels. Among the 141 participants with inflammatory bowel disease, 96 reported having health-related goals. Of these, 66 were female (68.75%), and 30 were male participants (31.25%). Path analysis revealed a moderate negative association between self-concordance (SC) and negative emotions, which, in turn, predicted higher levels of trait anxiety. Furthermore, the alternative model tested indicated that trait anxiety predicted a lower level of self-concordance. Setting well-integrated health goals involves an internal capacity, enabling patients to experience less negative emotions during self-management activities. Anxiety can hinder individuals from accessing their inner needs, resulting in less self-concordant aspirations and more negative emotions. These findings may contribute to developing prevention and intervention programs to enhance IBD patients’ adherence to lifestyle changes, ultimately improving their overall well-being.
The challenge of education for sustainability in higher education: key themes and competences within the University of the Basque Country
Authors: Idoiaga Mondragon Nahia , Yarritu Ion , Saez de Cámara Estibaliz , Beloki Nekane , Vozmediano Laura
Published: July 2023

Introduction

One of the major challenges for higher education institutions in the last decade has been (and will continue to be) the integration of sustainability into their curricula and the development of sustainability competences in students. Education for Sustainability (ES) can help prepare students to meet the challenges of making societies more sustainable. However, as a first step toward this goal, teachers need to incorporate ES into their teaching. In this regard, this research aimed to analyze if members of the teaching staff have started this integration and, if so, which sustainability-related topics have been introduced and which skills do they consider contribute to the development of future graduates.

Methods

A questionnaire was administered to teaching staff at the University of the Basque Country in 2022. A total of 403 teachers completed the questionnaire, expressing their perceptions through open-ended questions.

Results

In general terms teachers incorporate ES into their teaching (71.22%). However, they do this mainly within the framework of two general themes: “Environmental awareness and energy” – most used by teachers of experimental sciences and engineering – and “Social commitment,” most used by teachers of social sciences and those who are familiar with the UN 2030 Agenda for Sustainable Development. Regarding the key competences that ES provides for future graduates, those most frequently mentioned were “training of professionals committed to society” and “critical thinking and ethics.” These competences were particularly notable in the discourse of teachers who were aware of the 2030 Agenda and who use active methodologies in their classrooms. Finally, the opinion that sustainability has little to do with their teaching (28.78%) was notably expressed by teachers less familiar with the 2030 Agenda.

Discussion

Thus, it can be concluded that, aside from knowledge of the 2030 Agenda, factors such as the sustainability policy of the institution, area of teaching expertise, and the use of active methodologies all play a significant role in determining whether competences for sustainable development are integrated into higher education teaching.
How serving helps leading: mediators between servant leadership and affective commitment
Authors: Bai Mayangzong , Zheng Xinyi , Huang Xu , Jing Tiantian , Yu Chenhao , Li Sisi , Zhang Zhiruo
Published: July 2023

Introduction

Servant leadership has long been associated with maintaining employee’s affective commitment, yet the underlying mechanism remains unclear. Research from non-western cultures remains scarce.

Methods

This study sought to fill in such research gap by introducing insights from social exchange theory perspective, and examined two potential mediators (viz., psychological safety and job burnout) with a largescale, representative Chinese sample.

Results

A total of 931 staffs in a Chinese hospital were surveyed, and structural equation models revealed that psychological safety (indirect effect = 0.052, 95% Bootstrap CI = [0.002, 0.101]) and job burnout (indirect effect = 0.277, 95% Bootstrap CI = [0.226, 0.331]) parallelly (and partially) mediated the effect of servant leadership on affective commitment. Moreover, these effects held the same between permanent and temporary staffs, as well as between male and female staffs.

Discussion

Results suggested that a leader’s orientation to care, validate, and respond to their followers’ needs was effective in creating a psychological safe environment and downplaying job burnout in workplace, in exchange to which, followers remained affectively committed to their organization in a long term. Not only did this study contribute to existing literature by providing non-western data for service leadership research, it also provided a deeper understanding of associated mechanisms of how servant leadership might cast on talent retain and organizational development in a long term. These mechanisms shed light on how serving helps leading and advocate servant leadership for hospitals, as well as other serving organizations.
The effect of positive parenting on adolescent life satisfaction: the mediating role of parent-adolescent attachment
Authors: Li Mengge , Lan Ruiming , Ma Peng , Gong Huoliang
Published: July 2023

This study explores the impact of positive parenting on adolescents’ life satisfaction and the mediating role of parent-adolescent attachment, based on the family systems theory and attachment theory. The sample included 5,047 adolescents (2,353 males, 2,694 females) with a mean age of 16.65 (SD = 1.21) from Henan Province, China. This study used the Positive Parenting Scale, the Inventory of Parent and Peer Attachment and the Satisfaction with Life Scale to survey 5,047 adolescents. The results showed that: (1) father’s positive parenting positively predicted adolescent life satisfaction, while mother’s positive parenting did not significantly predict adolescent life satisfaction; (2) Father-adolescent attachment and mother-adolescent attachment play a mediating role in the relationship between fathers’ positive parenting, mothers’ positive parenting, and adolescent life satisfaction, respectively; (3) Differences in the mechanisms of father’s positive parenting and mother’s positive parenting on adolescent life satisfaction. Among them, mothers’ positive parenting positively predicts mother-adolescent attachment, which in turn affects adolescent life satisfaction. On the other hand, fathers’ positive parenting can influence adolescent life satisfaction through two pathways: by positively predicting father-adolescent attachment and by positively predicting mother-adolescent attachment. The research findings indicate that father’s and mother’s positive parenting have different direct effects on adolescent’s life satisfaction, and both can indirectly influence adolescent life satisfaction through the mediating variables of father-adolescent and mother-adolescent attachment. These findings have important theoretical and practical implications for promoting family education and adolescent psychological well-being.
Three joint temperament-character configurations account for learning, personality and well-being: normative demographic findings in a representative national population
Authors: Moreira Paulo A. S. , Inman Richard A. , Cloninger C. Robert
Published: July 2023

Introduction

A common practice in research and clinical practice is to use data considered representative of a target population to compare and understand the personality characteristics of specific groups or specific individuals. To this end, numerous studies have presented normative data for the temperament and character traits outlined in Cloninger’s psychobiological model of personality. However, recent genomic evidence demonstrates that human personality is organized as a complex hierarchy that ascends beyond the individual traits to multi-trait profiles that regulate emotional reactivity (temperament profiles) or goals and values (character profiles), and then to three phenotypic networks, which integrate temperament profiles and character profiles, that regulate learning. Given this recent understanding, our aim was to provide a novel and more comprehensive description of personality features at a societal level (using a stratified sample representative of the Portuguese population) by considering personality at its higher levels of complexity.

Methods

Toward this goal, a stratified sample of 2,443 Portuguese adults responded to the Revised Temperament and Character Inventory (TCI-R).

Results

We summarize the prevalence of (a) temperament profiles, (b) character profiles, and (c) integrated temperament-character networks within the whole sample, as well as for men vs. women and different age groups separately. Independent of age and education, women were more likely to be capable of resourceful productivity and helpful cooperation combined with being more intuitive, meditative and creative than men. Independent of age and gender, individuals with a degree were also more likely to present these biopsychosocial features. We also found that the organized character profile was most typical of adults in their 40s. Finally, the distribution of personality profiles across age differed as a function of gender: for men the oldest individuals had the most coherent personalities while high personality integration was most prevalent for women in their 30s.

Discussion

These results have strong implications for research and intervention. In particular, these results are relevant for understanding the epidemiology of interactions between personality, mental health and well-being, including their expressions in a national population as a function of demographic characteristics.
Association between life events, anxiety, depression and non-suicidal self-injury behavior in Chinese psychiatric adolescent inpatients: a cross-sectional study
Authors: Xiao Qingqing , Song Xiaozhen , Huang Lijuan , Hou Dandan , Huang Xuehua
Published: July 2023

Background

Non-suicidal self-injury (NSSI) is a major public health concern among adolescents. Further research is needed into contributors to this behavior, in particular among adolescents with psychiatric disorders. The aim of the present study was to explore the impact of life events and emotional stress on NSSI among hospitalized psychiatric adolescents.

Methods

In this cross-sectional study, 505 Chinese psychiatric adolescent inpatients 10–19  years old completed questionnaires about sociodemographic characteristics and NSSI as well as the Adolescent Self-Rating Life Events Checklist (ASLEC), the State–Trait Anxiety Inventory Form Y, and the Center for Epidemiological Studies Depression Scale. Chi-square test was used to compare the incidence of NSSI in psychiatric adolescent patients with different sociodemographic. T-test was used to compare the total scores and dimension scores of the ASLEC, STAI-Y, and CES-D between the NSSI group and the non-NSSI group. A binary logistic regression model was built to explore the relationships among sociodemographic characteristics, questionnaire scores and NSSI.

Results

Most psychiatric adolescent inpatients (393, 77.8%) reported NSSI behavior. The higher risk for NSSI was observed among female (odds ratio [OR] 2.665, 95% confidence interval [CI] 1.575–4.510), younger adolescents (10–14 years; OR 2.021, 95% CI 1.258–3.245), with a suicide history (OR 2.479, 95% CI 1.549–3.967), or with depression symptom (OR 3.217, 95% CI 1.572–6.582) and those with higher scores of ASLEC (OR 1.019, 95% CI 1.010–1.029).

Conclusion

Our study in China is one of the first to apply to adolescent inpatients the diagnostic criteria of NSSI in the latest edition of the Diagnostic and Statistical Manual of Mental Disorders. Our analysis suggests that NSSI prevalence is disturbingly high among adolescents with mental illness in China. A better understanding of contributing factors, especially negative life events and negative emotions, may guide interventions that can reduce its prevalence.
The prevalence of undernutrition among students attending traditional Ethiopian orthodox Tewahedo church schools in northwest Ethiopia
Authors: Shiferaw Yalelet Fentaw , Asmamaw Desale Bihonegn , Engidaw Melaku Tadege , Belay Daniel Gashaneh , Birhan Haileyesus , Negash Wubshet Debebe
Published: July 2023

Background

Undernutrition is a major public health concern affecting the health, growth, development, and academic performance of adolescents studying in school. During this crucial period, dietary patterns have a vital impact on lifetime nutritional status and health. The problem of undernutrition among particular groups of adolescents attending traditional schools has not previously been studied. Therefore, this study aimed to assess the prevalence of undernutrition and associated factors among adolescents aged 10–19 years attending Orthodox Church schools in northwest Ethiopia.

Methods

An institution-based, cross-sectional study design was employed, with data collected from March 1 to 30, 2021. A simple random sampling technique was used to recruit a total of 848 male attendees of traditional schools. Data were collected via an interviewer-administered semi-structured questionnaire. The nutritional status of participants was assessed using anthropometric measurements. The WHO Anthroplus software was used for analysis. Both bivariable and multivariable logistic regression analyses were conducted to identify the factors associated with nutritional status. The degree of association between the independent variables and the dependent variable was assessed using odds ratios, reported with 95% confidence intervals, and a threshold of p ≤ 0.05.

Results

The prevalence of undernutrition was found to be 61.3% [95% CI: 58.1, 64.6]. The likelihood of developing undernutrition was elevated among those adolescents who were following the traditional school levels of dikuna (AOR = 4.3, 95% CI = 1.3, 13.6), kinne (AOR = 4.5, 95% CI = 1.4, 14.6), aquaquame (AOR = 9.9, 95% CI = 2.5, 39.88), tirguame (AOR = 6.4, 95% CI = 1.6, 25.6), and among those whose mothers had no formal education [AOR = 3.7, 95% CI: 1.2, 12.8]. In contrast, those adolescents who always washed their hands after a toilet visit had lower odds of undernutrition than their counterparts [AOR = 0.7, 95%CI: 0.5, 0.98].

Conclusion

More than three out of five participating male adolescents were undernourished. Thus, to improve the nutritional status of adolescents studying in traditional church schools, extensive health education for these adolescents is essential. Moreover, the establishment of well-resourced traditional religious school, equipped for the provision of an adequate, diversified diet, is important. Developing the habit of handwashing after visiting the toilet and before and after food preparation is also recommended for adolescent students.
Diagnostics of inflammaging in relation to sarcopenia
Authors: Morawin Barbara , Tylutka Anna , Bielewicz Filip , Zembron-Lacny Agnieszka
Published: July 2023

One of the theories about aging focuses on the immune response and relates to the activation of subclinical and chronic inflammation. This study was designed to investigate the relationship between inflammation and sarcopenia and to evaluate the influence of lifestyle on the inflammatory profile. Finally, therapeutic strategies to counteract the pathophysiological effect of skeletal muscle aging were also indicated. One hundred seventy-three individuals aged 71.5 ± 6.8 years were divided into two groups: sarcopenia and probable sarcopenia (n = 39) and no sarcopenia (n = 134). Sarcopenia was assessed according to the algorithm of the European Working Group on Sarcopenia in the older adults 2. C-reactive protein (CRP) (p = 0.011) and CRP/albumin ratio (p = 0.030) as well as IL-1β (p = 0.002), cfDNA (p < 0.001) and bilirubin levels (p = 0.002) were significantly higher in the sarcopenia group as opposed to the no sarcopenia group. No significant differences were observed between groups in the concentration of TNFα (p = 0.429) and IL-6 (p = 0.300). An inverse correlation was found between gait speed and cfDNA (rs = −0.234, p < 0.01) and IL-1β (rs = −0.263, p < 0.01). The ROC analysis of cfDNA, CRP, IL-1β and bilirubin ranged from 0.6 to 0.7, which confirms the association between sarcopenia and inflammatory mediators and indicates high clinical usefulness of cfDNA and bilirubin in sarcopenia prediction. We also indicated a link between inflammation and fitness level in the older adult thereby providing evidence that lifestyle exercise should be a key therapeutic strategy in sarcopenia prevention.
Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging
Authors: Zhang Chi , Wang Dongmei , Dowell Robin , Yi Rui
Published: July 2023

Aging is defined as the functional decline of tissues and organisms, leading to many human conditions, such as cancer, neurodegenerative diseases, and hair loss. Although stem cell exhaustion is widely recognized as a hallmark of aging, our understanding of cell state changes–specifically, the dynamics of the transcriptome and open chromatin landscape, and their relationship with aging–remains incomplete. Here we present a longitudinal, single-cell atlas of the transcriptome and open chromatin landscape for epithelia cells of the skin across various hair cycle stages and ages in mice. Our findings reveal fluctuating hair follicle stem cell (HF-SC) states, some of which are associated with the progression of the hair cycle during aging. Conversely, inner bulge niche cells display a more linear progression, seemingly less affected by the hair cycle. Further analysis of the open chromatin landscape, determined by single-cell Assay for Transposase-Accessible Chromatin (ATAC) sequencing, demonstrates that reduced open chromatin regions in HF-SCs are associated with differentiation, whereas gained open chromatin regions in HF-SCs are linked to the transcriptional control of quiescence. These findings enhance our understanding of the transcriptional dynamics in HF-SC aging and lay the molecular groundwork for investigating and potentially reversing the aging process in future experimental studies.
Case report: Imaging features of aorta-right atrial tunnel in a dog using two-dimensional echocardiography and computed tomography
Authors: Kim Geunha , Ji Yewon , Jeong Ho-Gyun , Lee Taekwon , Lee Kichang , Yoon Hakyoung
Published: July 2023

A 7-year-old castrated male Pomeranian dog weighing 5 kg presented with a right-sided continuous murmur without any clinical signs. Thoracic radiographs indicated cardiomegaly and right atrial (RA) bulging. Echocardiography revealed a tunnel originating from the right coronary sinus of Valsalva and terminating in the RA. Contrast echocardiography revealed pulmonary arteriovenous anastomoses. Computed tomography (CT) demonstrated a tortuous shunting vessel that originated from the aorta extending in a ventral direction, ran along the right ventricular wall, and was inserted into the RA. Based on these diagnostic findings, the dog was diagnosed with the aorta-RA tunnel. At the 1-year follow-up visit without treatment, the dog showed no significant change except for mild left ventricular volume overload and mildly decreased contractility. To the best of our knowledge, this is the first case report of an aorta-RA tunnel that has been described in detail using echocardiography and CT in a dog. In conclusion, the aorta-RA tunnel should be included in the clinical differential diagnoses if a right-sided continuous murmur is heard or shunt flow originating from the aortic root is identified.
The use of body surface temperatures in assessing thermal status of hutch-reared dairy calves in shaded and unshaded conditions
Authors: Bakony Mikolt , Kovács Levente , Kézér Luca Fruzsina , Jurkovich Viktor
Published: July 2023

The study was carried out in a Hungarian large-scale dairy farm during a 5-day period in hot August weather. Altogether 16 preweaning calves were chosen for the study. An agricultural mesh with 80% shielding was stretched over eight calf cages at 2 m from the ground to shield the cages in their entirety, while eight others were left unshaded. Ambient temperature and relative humidity were measured in 10 min intervals inside and outside one of the hutches in the shaded and unshaded groups during the total length of the study. The rectal temperature of the calves was measured by a digital thermometer every 4 h. Surface temperatures were measured on body parts, in the same intervals as rectal temperature with an infrared thermometer. Measuring sites included: the leg (metacarpus), muzzle, eye bulb, scapula, and ear. Statistical analyses were performed to assess the effects of shading on environmental and body temperatures and to also assess the strength of the association between core, skin and ambient temperatures; to estimate the temperature gradient between body shell and core; to compare the changes in heat dissipation capacity of the different body regions (as represented by temperatures of various sites) with increasing ambient temperature controlling for shaded or unshaded conditions; and to predict the risk of hyperthermia (rectal temperature not lower than 39.5°C) with the CART classification method. The average rectal temperatures suggest that the temperature conditions both in shaded and unshaded groups imposed a severe heat load on the calves. The temperature of the body shell, as represented by skin temperatures, shows a much more significant variation, similar to ambient temperature. As expected, areas that are closer to the core of the body (ear and eye) show less difference from rectal temperature and show a narrower range (lower variance), as more distal regions (leg, scapula) have a wider range. Body surface temperatures are more related to ambient temperature in calves than rectal temperature. The predictive value of infrared body surface temperatures for predicting heat stress or rectal temperature is low.
Risk-Sensitive Policy with Distributional Reinforcement Learning
Authors: Théate Thibaut , Ernst Damien
Published: July 2023

Classical reinforcement learning (RL) techniques are generally concerned with the design of decision-making policies driven by the maximisation of the expected outcome. Nevertheless, this approach does not take into consideration the potential risk associated with the actions taken, which may be critical in certain applications. To address that issue, the present research work introduces a novel methodology based on distributional RL to derive sequential decision-making policies that are sensitive to the risk, the latter being modelled by the tail of the return probability distribution. The core idea is to replace the Q function generally standing at the core of learning schemes in RL by another function, taking into account both the expected return and the risk. Named the risk-based utility function U, it can be extracted from the random return distribution Z naturally learnt by any distributional RL algorithm. This enables the spanning of the complete potential trade-off between risk minimisation and expected return maximisation, in contrast to fully risk-averse methodologies. Fundamentally, this research yields a truly practical and accessible solution for learning risk-sensitive policies with minimal modification to the distributional RL algorithm, with an emphasis on the interpretability of the resulting decision-making process.
Tracking-Differentiator-Based Position and Acceleration Feedback Control in Active Vibration Isolation with Electromagnetic Actuator
Authors: Huang Cuicui , Yang Yang , Dai Chunhui , Long Zhiqiang
Published: July 2023

In order to improve the performance of the active vibration isolation system (AVIS) with electromagnetic actuator, several problems of vibration control are studied. Position control is a critical component in suspension systems, and the position sensor noise can extremely affect the stability of the system, so a tracking differentiator (TD) is proposed to obtain effective differential signal from relative position sensor. In vibration control, the feedback of acceleration combined with PD position feedback is presented to suppress transmission of periodic vibrations. Then, taking the acceleration transmission as the evaluation index, the acceleration transmission under the presented control method is derived, and the influence of control parameters on vibration isolation performance is discussed in detail. The vibration isolation performance is improved from 24.47 dB to 2.4 dB at resonance frequency, and −34 dB attenuation is achieved at 100 Hz with respect to vibration isolation mount system tested on the ground. The experimental results demonstrate that the performance of active vibration isolation system are improved by the proposed acceleration feedback control.
Clamping Force Control Strategy of Electro-Mechanical Brake System Using VUF-PID Controller
Authors: Chen Qiping , Lv Zongyu , Tong Haiyang , Xiong Zuqi
Published: July 2023

Clamping force control is one of the key technologies in the algorithm design and implementation of electro-mechanical braking system, whose control effects directly affect the vehicle braking performance and safety performance. In order to improve the clamping force control performance of electro-mechanical braking (EMB) system, an EMB clamping force control method based on Variable universe adaptive fuzzy PID (VUF-PID) controller is proposed, and stretching factors are added to the fuzzy PID control. According to the operation of the controlled object, the fuzzy theory domain can be adjusted in real time to keep the system in the proper parameter value and improve the adaptive ability of the system. The response characteristics and effectiveness of clamping force under step braking condition, gear switching braking condition and sine braking condition are verified by simulation experiments using MATLAB/Simulink. The results show that the proposed VUF-PID control method has strong tracking characteristics and stability characteristics, and meet the braking requirements under different braking conditions.
Translating Organizational Change into Entrepreneurial Identity—A Study of Energy Transition in a Large State-Owned Enterprise
Authors: Landoni Matteo
Published: July 2023

This paper presents a proximal study of energy transition in a large state-owned enterprise. Organizational change is the prerequisite for energy transition in a company that has historically understood its own identity in the remunerative oil gas industry. The methodology of the research is a qualitative on-field study of the implementation of the transition strategy inside the company. For this purpose, the research uses primarily first-hand reports collected within the organization in the years 2018–2020. The paper explores the dynamic process of change to reveal the tensions, conflicting identities, and strategies of implementation needed to start the energy transition, shedding light on the formation of a new corporate identity that traces back to the entrepreneurial inception of the company. The role of communication between the different levels of the company was crucial. The management found in the corporate history a moderator of organizational change that led to a renewed entrepreneurial identity. This paper brings evidence that a re-interpretation of the corporate identity is a condition that eases the process of organizational change. The results of the study will provide the theory with a practical case in order to better understand the transitions of state-owned enterprises in their effort to promote organizational change and drive sustainable innovations.
Numerical Simulation of the Lunar Polar Environment: Implications for Rover Exploration Challenge
Authors: Gan Hong , Zhao Chengxuan , Wei Guangfei , Li Xiongyao , Xia Guojun , Zhang Xiao , Shi Jingjing
Published: July 2023

The lunar polar regions are key areas for future exploration due to the long-term continuous illumination and persistently shadowed regions that can cold trap abundant water and other volatiles. However, the complex terrain, dynamic lighting, and solar wind-induced electric-field environment present multiple challenges for polar investigation and sampling missions. China’s Chang’E-7 (CE-7) will explore the Moon’s south polar region in 2026. One of the scientific goals is to drill samples in a wide area with a rover for in situ analysis. This study analyzes the engineering constraints of the polar illumination condition, slopes, and electric field for landing and sampling-site selection. Then, we create a 3D model of CE-7’s lunar rover in three operating environments by employing the Spacecraft Plasma Interaction Software, with the rover sampling (i) on a flat surface, (ii) in a shadow, and (iii) near a meter-scale crater under different solar altitude angles. The results show that the rover can be charged to different potentials under the combined effects of solar wind incident angles and surrounding terrains. We find that a favorable traversing and/or sampling site of the rover for future polar exploration is in the upwind direction of a bulge (positively elevated terrains, such as the lander or boulders) or crater, which will cause a minimum charging effect on the rover. Our results have important implications for minimizing the risk of charging effects and guiding the lunar polar region exploration.
Natural Language Processing (NLP) in Aviation Safety: Systematic Review of Research and Outlook into the Future
Authors: Yang Chuyang , Huang Chenyu
Published: July 2023

Advanced digital data-driven applications have evolved and significantly impacted the transportation sector in recent years. This systematic review examines natural language processing (NLP) approaches applied to aviation safety-related domains. The authors use Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to conduct this review, and three databases (Web of Science, Scopus, and Transportation Research International Documentation) are screened. Academic articles from the period 2010–2022 are reviewed after applying two rounds of filtering criteria. The sub-domains, including aviation incident/accident reports analysis and air traffic control (ATC) communications, are investigated. The specific NLP approaches, related machine learning algorithms, additional causality models, and the corresponding performance are identified and summarized. In addition, the challenges and limitations of current NLP applications in aviation, such as ambiguity, limited training data, lack of multilingual support, are discussed. Finally, this review uncovers future opportunities to leverage NLP models to facilitate the safety and efficiency of the aviation system.
Robots and Autonomous Machines for Sustainable Agriculture Production
Authors: Yuan Jin , Ji Wei , Feng Qingchun
Published: July 2023

The global agriculture faces critical pressures, including an aging population, rising production costs, and labor shortages [...]