bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive Modeling of Alzheimer’s and Parkinson’s Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid
Authors: Hwangbo Nathan , Zhang Xinyu , Raftery Daniel , Gu Haiwei , Hu Shu-Ching , Montine Thomas J. , Quinn Joseph F. , Chung Kathryn A. , Hiller Amie L. , Wang Dongfang , Fei Qiang , Bettcher Lisa , Zabetian Cyrus P. , Peskind Elaine R. , Li Ge , Promislow Daniel E. L. , Davis Marie Y. , Franks Alexander
Published: March 2022

In recent years, metabolomics has been used as a powerful tool to better understand the physiology of neurodegenerative diseases and identify potential biomarkers for progression. We used targeted and untargeted aqueous, and lipidomic profiles of the metabolome from human cerebrospinal fluid to build multivariate predictive models distinguishing patients with Alzheimer’s disease (AD), Parkinson’s disease (PD), and healthy age-matched controls. We emphasize several statistical challenges associated with metabolomic studies where the number of measured metabolites far exceeds sample size. We found strong separation in the metabolome between PD and controls, as well as between PD and AD, with weaker separation between AD and controls. Consistent with existing literature, we found alanine, kynurenine, tryptophan, and serine to be associated with PD classification against controls, while alanine, creatine, and long chain ceramides were associated with AD classification against controls. We conducted a univariate pathway analysis of untargeted and targeted metabolite profiles and find that vitamin E and urea cycle metabolism pathways are associated with PD, while the aspartate/asparagine and c21-steroid hormone biosynthesis pathways are associated with AD. We also found that the amount of metabolite missingness varied by phenotype, highlighting the importance of examining missing data in future metabolomic studies.
Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer’s Disease Mouse Model
Authors: Guzzardi Maria Angela , La Rosa Federica , Campani Daniela , Collado Maria Carmen , Monleon Daniel , Cacciato Insilla Andrea , Tripodi Maria , Zega Alessandro , Dattilo Alessia , Brunetto Maurizia Rossana , Maffei Margherita , Bonino Ferruccio , Iozzo Patricia
Published: March 2022

Metabolic impairments and liver and adipose depots alterations were reported in subjects with Alzheimer’s disease (AD), highlighting the role of the liver–adipose–tissue–brain axis in AD pathophysiology. The gut microbiota might play a modulating role. We investigated the alterations to the liver and white/brown adipose tissues (W/BAT) and their relationships with serum and gut metabolites and gut bacteria in a 3xTg mouse model during AD onset (adulthood) and progression (aging) and the impact of high-fat diet (HFD) and intranasal insulin (INI). Glucose metabolism (18FDG-PET), tissue radiodensity (CT), liver and W/BAT histology, BAT-thermogenic markers were analyzed. 16S-RNA sequencing and mass-spectrometry were performed in adult (8 months) and aged (14 months) 3xTg-AD mice with a high-fat or control diet. Generalized and HFD resistant deficiency of lipid accumulation in both liver and W/BAT, hypermetabolism in WAT (adulthood) and BAT (aging), abnormal cytokine–hormone profiles, and liver inflammation were observed in 3xTg mice; INI could antagonize all these alterations. Specific gut microbiota–metabolome profiles correlated with a significant disruption of the gut–microbiota–liver–adipose axis in AD mice. In conclusion, fat dystrophy in liver and adipose depots contributes to AD progression, and associates with altered profiles of the gut microbiota, which candidates as an appealing early target for preventive intervention.
Functional Devices from Bottom-Up Silicon Nanowires: A Review
Authors: Arjmand Tabassom , Legallais Maxime , Nguyen Thi Thu Thuy , Serre Pauline , Vallejo-Perez Monica , Morisot Fanny , Salem Bassem , Ternon Céline
Published: March 2022

This paper summarizes some of the essential aspects for the fabrication of functional devices from bottom-up silicon nanowires. In a first part, the different ways of exploiting nanowires in functional devices, from single nanowires to large assemblies of nanowires such as nanonets (two-dimensional arrays of randomly oriented nanowires), are briefly reviewed. Subsequently, the main properties of nanowires are discussed followed by those of nanonets that benefit from the large numbers of nanowires involved. After describing the main techniques used for the growth of nanowires, in the context of functional device fabrication, the different techniques used for nanowire manipulation are largely presented as they constitute one of the first fundamental steps that allows the nanowire positioning necessary to start the integration process. The advantages and disadvantages of each of these manipulation techniques are discussed. Then, the main families of nanowire-based transistors are presented; their most common integration routes and the electrical performance of the resulting devices are also presented and compared in order to highlight the relevance of these different geometries. Because they can be bottlenecks, the key technological elements necessary for the integration of silicon nanowires are detailed: the sintering technique, the importance of surface and interface engineering, and the key role of silicidation for good device performance. Finally the main application areas for these silicon nanowire devices are reviewed.
A Comprehensive Review of Layered Double Hydroxide-Based Carbon Composites as an Environmental Multifunctional Material for Wastewater Treatment
Authors: Huang Yongxiang , Liu Chongmin , Rad Saeed , He Huijun , Qin Litang
Published: March 2022

As is well known, hydrotalcite-like compounds, such as layered-double-hydroxide (LDH) materials, have shown great potential applications in many fields owing to their unique characteristics, including a higher anion exchange capacity, a structure memory effect, low costs, and remarkable recyclability. While the lower surface area and leaching of metal ions from LDH composites reduce the process efficiency of the catalyst, combining LDH materials with other materials can improve the surface properties of the composites and enhance the catalytic performance. Among organic compounds, carbon materials can be used as synergistic materials to overcome the defects of LDHs and provide better performance for environmental functional materials, including adsorption materials, electrode materials, photocatalytic materials, and separation materials. Therefore, this article comprehensively reviews recent works on the preparation and application of layered double-hydroxide-based carbon (LDH–C) composites as synergistic materials in the field of environmental remediation. In addition, their corresponding mechanisms are discussed in depth. Finally, some perspectives are proposed for further research directions on exploring efficient and low-cost clay composite materials.
Frequency Response Estimation for Multiple Aircraft Control Loops Using Orthogonal Phase-Optimized Multisine Inputs
Authors: Grauer Jared A.
Published: March 2022

The latest advances made at NASA for simultaneous excitation in multiple axes and the identification of frequency responses for aircraft flight systems are discussed in this paper. These techniques are extended in the prospect of identifying multiple dynamics and control loops for multiple axes. Recent applications with flight test data and simulation data are also presented, along with a discussion of the practical aspects of the approach. A demonstration is also provided, using a simulation model for the X-59 airplane in which frequency responses for the bare-airframe, closed-loop, and broken-loop (both for the actuator and the sensor) dynamics were identified from a single 60 s maneuver. The results indicate that this approach can significantly shorten the duration of flight tests and Monte Carlo simulations to save time and costs, and can produce results in real time.
Qualitative Methods with Nvivo Software: A Practical Guide for Analyzing Qualitative Data
Authors: Allsop David B. , Chelladurai Joe M. , Kimball Elisabeth R. , Marks Loren D. , Hendricks Justin J.
Published: March 2022

From 1995–2016, there has been a 15-fold increase in qualitative scholarship in the social sciences, but the rigor and quality of published work has ranged widely. Little scholarship provides concrete, pragmatic explanations of (and directions regarding) the execution of systematic, high-rigor qualitative analysis. The present article guides the developing qualitative researcher through technical and procedural aspects of analyzing qualitative data with specific attention to reliability and rigor. Guidance addressing transcription, importing data, forming coding pairs, performing initial/open coding (examples of three types), determining core themes, systematic team-based coding, maintaining a data audit trail, creating a Numeric Content Analysis (NCA) table, and preparing work for publication is provided. Materials include several tables and figures that offer practical demonstrations on how to use Nvivo in data analysis. Transcription tips and outsourcing benefits and cautions are also offered. Altogether, the present article provides qualitative researchers practical guidance for executing multiple stages of qualitative analysis.
The Use of Microsensors to Assess the Daily Wear Time of Removable Orthodontic Appliances: A Prospective Cohort Study
Authors: Nahajowski Marek , Lis Joanna , Sarul Michał
Published: March 2022

Orthodontic treatment with removable appliances is still common in children and adolescents. However, their effectiveness depends primarily on the patients’ compliance. Currently, it is possible to check the daily wear time (DWT) of the removable appliances using special microsensors. The aim of this prospective cohort study was to assess the degree of patients’ compliance depending on the type of removable appliance used. In total, 167 patients (87 F, 80 M) were enrolled in the study and were treated with block appliances (Klammt, Twin-Block), Schwarz plates, and block appliances in combination with headgear. All patients were followed up for 6 months with the mean daily wear time checked at followup visits using TheraMon® microsensors fitted in the appliances. It has been shown that the type of appliance influences the patients’ compliance. The DWT for the Twin Block was significantly longer compared to the DWT for the other appliances. Girls have been shown to wear removable appliances better than boys. It has been proven that the majority of patients do not follow the orthodontist’s recommendations, wearing removable appliances for just over half of the recommended time. Microsensors can be used for objective verification of patients’ compliance, which allows for a reliable assessment of the effectiveness of treatment with removable appliances.
Design and Application of Intelligent Reflecting Surface (IRS) for Beyond 5G Wireless Networks: A Review
Authors: Okogbaa Fred Chimzi , Ahmed Qasim Zeeshan , Khan Fahd Ahmed , Abbas Waqas Bin , Che Fuhu , Zaidi Syed Ali Raza , Alade Temitope
Published: March 2022

The existing sub-6 GHz band is insufficient to support the bandwidth requirement of emerging data-rate-hungry applications and Internet of Things devices, requiring ultrareliable low latency communication (URLLC), thus making the migration to millimeter-wave (mmWave) bands inevitable. A notable disadvantage of a mmWave band is the significant losses suffered at higher frequencies that may not be overcome by novel optimization algorithms at the transmitter and receiver and thus result in a performance degradation. To address this, Intelligent Reflecting Surface (IRS) is a new technology capable of transforming the wireless channel from a highly probabilistic to a highly deterministic channel and as a result, overcome the significant losses experienced in the mmWave band. This paper aims to survey the design and applications of an IRS, a 2-dimensional (2D) passive metasurface with the ability to control the wireless propagation channel and thus achieve better spectral efficiency (SE) and energy efficiency (EE) to aid the fifth and beyond generation to deliver the required data rate to support current and emerging technologies. It is imperative that the future wireless technology evolves toward an intelligent software paradigm, and the IRS is expected to be a key enabler in achieving this task. This work provides a detailed survey of the IRS technology, limitations in the current research, and the related research opportunities and possible solutions.
Migration Barrier Estimation of Carbon in Lead for Lead–Acid Battery Applications: A Density Functional Theory Approach
Authors: Yanamandra Kaushik , Behera Rakesh K. , Daoud Atef , Gupta Nikhil
Published: March 2022

Recent efforts towards developing novel lead electrodes involving carbon and lead composites have shown potential for increasing the cycle life of lead–acid (LA) batteries used to store energy in various applications. In this study, first-principles calculations are used to examine the structural stability, defect formation energy, and migration barrier of C in Pb for LA batteries. Density functional theory with the GGA-PBE functional performed the best out of various functionals used for structural stability calculations. Furthermore, with the complete incorporation of C in the Pb matrix, the results show that C is energetically preferred to be at the octahedral interstitial (CiOcta) site in the FCC structure of Pb. Additionally, climbing-image nudged elastic band calculations show a minimum energy pathway for C diffusing from a stable octahedral site to the adjacent octahedral site assisted by a tetrahedral intermediate site. Therefore, the minimum energy pathway for C migration is envisioned to be CiOcta→ CiTetra→CiOcta, where the total energy barrier is observed to be ~90% and more than 100% lower than the CiTetra→CiTetra and CiOcta→CiOcta barriers, respectively.
Business Innovation in Orchestra Organizations Supported by Digital Technologies: The Orchestra Mobile Case Study
Authors: Poulios Ioannis , Kamperou Efrosini
Published: March 2022

In an attempt to deal with challenges such as increased competition, the global economic crisis, and the pandemic crisis, cultural organizations increasingly tend to adopt business theories and tools. The present paper addresses this issue in an industry that is not very frequently discussed, that of orchestra, using Orchestra Mobile as the case study. Based on literature review and interviews, and with reference to some of the latest, innovative approaches to management and strategy supported by digital technologies, the paper examines how this new entry in the industry (in 2010): (i) not attached to a concert hall (and, therefore, dependent on others) and with no state funding, survived against established organizations of global recognition, who were attached to prestigious concert halls, and enjoyed strong funding on the part of the state; (ii) with no external support, succeeded within the peak of the global economic crisis; (iii) decided long before the pandemic crisis to operate mostly at a distance, based on geographically dispersed members and collaborators; and, more importantly, (iv) challenged the rules of an industry that were formed in the 18th and 19th centuries and have not been (substantially) challenged ever since. The conclusions on the complex relationship of “sustainability-innovation-digital technologies” could be of benefit to a wide range of cultural organizations and entrepreneurs.
Analogue Metric in a Black-Bounce Background
Authors: Pal Kunal , Pal Kuntal , Sarkar Tapobrata
Published: March 2022

The conventional approach of embedding an effective acoustic metric for sound motion in a background flat Minkowski space-time has recently been extended to incorporate more general curved background metrics, which might contain a black hole. Though the observational aspects of these kinds of acoustics horizons, including the sonic shadow structure and quasi normal modes, have received significant attention in the literature, there is room left for discussions about embedding more general classes of curved background space-times without optical horizons. Here, we propose and study a new class of acoustic metrics that is embedded in a black-bounce space-time, thereby giving a suitable tuneable system to understand possible observational effects of the presence or absence of acoustic horizons. After showing that the metric can represent five types of different effective backgrounds for sound motion, including a novel “acoustic wormhole–optical wormhole” branch, we discuss how the distinctive features of sonic shadows can appear even in the absence of any acoustic horizon due to the wormhole throat present in the acoustic metric.
Pivotal Shigella Vaccine Efficacy Trials—Study Design Considerations from a Shigella Vaccine Trial Design Working Group
Authors: Pavlinac Patricia B. , Rogawski McQuade Elizabeth T. , Platts-Mills James A. , Kotloff Karen L. , Deal Carolyn , Giersing Birgitte K. , Isbrucker Richard A. , Kang Gagandeep , Ma Lyou-Fu , MacLennan Calman A. , Patriarca Peter , Steele Duncan , Vannice Kirsten S.
Published: March 2022

Vaccine candidates for Shigella are approaching phase 3 clinical trials in the target population of young children living in low- and middle-income countries. Key study design decisions will need to be made to maximize the success of such trials and minimize the time to licensure and implementation. We convened an ad hoc working group to identify the key aspects of trial design that would meet the regulatory requirements to achieve the desired indication of prevention of moderate or severe shigellosis due to strains included in the vaccine. The proposed primary endpoint of pivotal Shigella vaccine trials is the efficacy of the vaccine against the first episode of acute moderate or severe diarrhea caused by the Shigella strains contained within the vaccine. Moderate or severe shigellosis could be defined by a modified Vesikari score with dysentery and molecular detection of vaccine-preventable Shigella strains. This report summarizes the rationale and current data behind these considerations, which will evolve as new data become available and after further review and consultation by global regulators and policymakers.
A Refined-Line-Based Method to Estimate Vanishing Points for Vision-Based Autonomous Vehicles
Authors: Shen Shengyao , Wang Shanshan , Wang Luping , Wei Hui
Published: March 2022

Helping vehicles estimate vanishing points (VPs) in traffic environments has considerable value in the field of autonomous driving. It has multiple unaddressed issues such as refining extracted lines and removing spurious VP candidates, which suffers from low accuracy and high computational cost in a complex traffic environment. To address these two issues, we present in this study a new model to estimate VPs from a monocular camera. Lines that belong to structured configuration and orientation are refined. At that point, it is possible to estimate VPs through extracting their corresponding vanishing candidates through optimal estimation. The algorithm requires no prior training and it has better robustness to color and illumination on the base of geometric inferences. Through comparing estimated VPs to the ground truth, the percentage of pixel errors were evaluated. The results proved that the methodology is successful in estimating VPs, meeting the requirements for vision-based autonomous vehicles.
Detection of African Swine Fever at an Abattoir in South Korea, 2020
Authors: Cho Ki-Hyun , Kim Hyun-Joo , Jang Min-Kyung , Ryu Ji-Hyoung , Yoo Daesung , Kang Hae-Eun , Park Jee-Yong
Published: March 2022

In October 2020, a suspect case of African swine fever (ASF) was detected at an abattoir located in the north-central border region of South Korea. The farm of origin was traced and confirmed positive for ASF. This recurrence was following a period of absence of outbreaks in domestic pigs after the first incursion in 2019, during which a total of 14 domestic pig farms were confirmed between September and October 2019. In 2020, a total of two farms were confirmed, and the molecular characterization of key regions of the genome showed that the two isolates from 2020 were identical with the previous isolates from South Korea in 2019. The continued spread and circulation of ASF in the wild boar population represents an increased risk of spill-over outbreaks in domestic pigs, and, therefore, additional control measures should be implemented for farms in these regions, including a heightened level of surveillance. This was the case for the index farm, which was required to send pigs only to the designated abattoir at which the suspect case was quickly detected. The improvement of biosecurity in pig farms, particularly at the wild boar–domestic pig interface, will be key to the successful control of ASF in the region.
Пирит зон сульфидизации терригенных комплексов Яно-Колымского орогенного пояса (Северо-Восток России): генерации, типохимизм, минеральные ассоциации
Authors:   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan, Sotskaya O. T. , Semyshev F. I. ,   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan, Malinovsky M. A. ,   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan, Al'shevsky A. V. ,   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan, Livach A. E. ,   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan, Goryachev N. A. ,   North-East Interdisciplinary Scientific Research Institute n. a. N. A. Shilo, FEB RAS, Magadan
Published: March 2022

Finely disseminated sulfide mineralization in terrigenous carbon-bearing strata is known to have a certain metal-bearing potential and to be an additional source of ores for deposits. In the zones of finely disseminated sulfide mineralization in the Debinsky, Chay-Yuryinsky and Orotukan-Srednekansky faults of the Yana-Kolyma orogenic belt, three generations of pyrite have been identified and studied: sedimentogenic, hydrothermal-metamorphogenic, and tentatively ore-hydrothermal with different sets of mineral associations. The studies were carried out in the Late Triassic and Early Jurassic sediments adjacent to the faults in the basins of the Spokoyny-Matrosova Creek, the Chay-Yurya River, the Ozyorny Creek, the Khara-Yuryakh Creek, the Nera River, and the Pravy Srednekan River. It was found that the sulfide mineralization had been formed in several stages. Morphological and genetic varieties of pyrite permit to distinguish sedimentary and metamorphogenic pyrite from ore pyrite. According to the quantitative analysis performed on a Camebax microanalyzer with an EDS detector X-Max Oxford, the main trace impurities in pyrite are As, Co, and Ni.
Морфологическое разнообразие лиственницы Каяндера (Larix сajanderi Mayr) по форме семенных чешуй шишек в пенжинской популяции (Северная Корякия)
Authors:   Kamchatka Branch of the Pacific Geographical Institute, FEB RAS, Petropavlovsk-Kamchatsky, Vetrova V. P. , Neshatayev V. Yu. ,   State Forest Technic University n. a. S. M. Kirov, St. Petersburg, Neshataeva V. Yu. ,   Komarov Botanical Institute, RAS, St. Petersburg, Barchenkov A. P. ,   V. N. Sukachev Institute of Forest, SB RAS, Krasnoyarsk,   Siberian Federal University, Krasnoyarsk, Sinelnikova N. V. ,   Institute of Biological Problems of the North, FEB RAS, Magadan
Published: March 2022

The diversity in the shape of cone scales of Larix cajanderi Mayr in the Penzhina population (North of Koryakia) was estimated using geometric morphometry methods. The study aimed in comparing the Penzhina population with other larch populations in Northeast Asia by the shape of cone scales and in identifying its geographical connections. A sample of 360 cones, collected from 36 larch trees in the middle reaches of the Penzhina River, was analyzed. Scales taken from the middle part of the cones were scanned, and outline points were placed with the screen digitizer using angular algorithm. Fourteen morphotypes of cone scales were distinguished by pairwise comparison of samples from each tree using Bootstrap resampling-based Goodall\'s F-test. These morphotypes were compared with those previously determined in the larch populations from Yakutia, Magadan Oblast, and the Kamchatka Peninsula. The morphotypes composition and frequency were used to determine phenotypic distances between populations. Cluster analysis and multidimensional scaling of the phenotypic distances were applied for ordination of the larch populations. All Penzhina morphotypes corresponded to the morphotypes of cone scales previously identified in the Yakutia and Magadan Cajander larch populations; two morphotypes were found earlier in the Kamchatka populations. By the shape of cone scales, the larch of the Penzhina population is close to the Yakutia populations of L. cajanderi. One can assume that the formation of larch forests in the Penzhina River valley mainly occurred due to the settlement of the larch from the Yakutia Pleistocene refugia. The Kamchatka cone scale morphotypes identical to those found in the Penzhina and Kolyma larch populations may indicate the migration of larch from the continent to the peninsula.
A Review of Polymer Physics and Potential Applications to Radiation Biophysics and Neurodegenerative Disorders
Authors: Chaturvedi Archit
Published: March 2022

Polymers are an essential aspect of molecular biology and biochemistry. The most significant of macromolecules involved in biological processes and phenomena are polymers. In this article, we provide a comprehensive summary of the proposed physical models for the configuration of polymers. Such physical models include the freely-jointed chain, freely-rotating chain, worm-like chain, and the Gaussian chain model. We then connect these models to the existing models regarding the radiation biophysics of DNA damage, as well as to the damage of RNA molecules, and provide an insight into future areas of research in the subject areas. The conclusion is that polymer physics and the Linear-Quadratic model can be used for future biophysical research in cancer and neurological disorders. Through such connections, we hope to provide a potential future insight with regards to biophysical research in cancer and neurodegenerative disorders.
Exceptional instruments in normalized contexts
Authors: Maya Antton
Published: March 2022

Transitional justice proposes exceptional tools so as to deal with non-ordinary periods, such as transitions to democracy and transitions to peace. These instruments, among which Truth and Reconciliation Commissions are the best known, are booming, and have a specific echo in the Basque Autonomous Community, at the crossroads between exceptionality and normality. This article aims at underlining the specificity of this territory, where the complexity of the transitions to democracy and peace builds a unique panorama of victims. This contexts gives birth to a progressive and pragmatic aplication of the exceptional instruments of transitional justice in a normalized and democratized context, and implies legal innovations, adapted to specific challenges.
Legal culture and image in the Brazilian courts
Authors: Riccio Vicente , Diniz Guedes Clarissa
Published: March 2022

This article discusses the interpretation of images by Brazilian courts and how the legal culture is part of this process. The use of the image as a means of proof differs qualitatively from the evidence traditionally applied in the judiciary, such as documents or witnesses. The image is characterized by instantaneity, emotionality, and immediacy. In addition, the media allow the construction of different meanings, implicit or explicit. The analysis varies according to the nature of the legal systems. In the adversarial legal system (Anglo-Saxon) the images are submitted to cross-examination and debated orally. In the civil law system, the role of the magistrate is preponderant, being responsible for the images’ validity. The research found that magistrates incorporate the content of their videos into their decisions based on experts’ opinions or witnesses’ testimonials who have viewed the images. This highlights a legal culture that is based on formalism and is ill-prepared to deal with the particularities of the image.
Digital Transformation: Digital Maturity Model for Turkish Businesses
Authors: MERDİN Deniz , ERSÖZ Filiz , TAŞKIN Harun
Published: March 2022

Changing market expectations and the increasing prevalence of the new technological trend in the world force businesses for digital transformation. However, the late realization of transformation opportunities may have devastating effects on businesses. As the first step of digital transformation, it is necessary to determine the status and deficiencies of businesses. Therefore, businesses need to make a comprehensive assessment with the digital maturity model. This study was conducted to provide businesses with an idea about the relevant digital transformation processes, to direct them toward the processes, and to support these activities when they are initiated. In the study, seven scales were developed, and the dimensions of the digital maturity model were formed. The dimensions of model were determined as strategy, customers, employees, process management, technology and data management, organizational culture, and innovation. This study aimed to examine the reliability and validity of the dimensions of the digital maturity model developed. In this context, the developed scales were applied to businesses in Turkey, and explanatory factor analysis (EFA) and validity analysis were performed. The scales were updated according to the analysis results. Moreover, the analysis results of the study were also used to specify the criteria of the model. The findings indicated that the developed scales were usable. It was purposed to provide researchers and businesses with significant opportunities since the model had a wide area of application and included environmental elements.
Xundak eta ezpondak. Laborantzarako terraza-sistemak Nafarroako isurialde atlantiarrean: Baztan haraneko zenbait adibide
Authors: Narbarte Hernández Josu , Aiestaran Mattin , Errarte Zurutuza Maite , Matelo Mitxelena Suberri
Published: March 2022

Laborantzarako terraza-sistemak elementu garrantzitsua dira Nafarroa iparreko landa-paisaiaren baitan. Lan honetan, Baztan haraneko lau herri adibide hartuta, terraza-sistemen ezaugarri nagusiak aztertu ditugu: kokapena, morfologia, eraikuntza-teknikak eta abar. Lortutako emaitzek erakusten dutenez, herri hauen inguruan kokatutako terraza-sistemek multzo homogeneoak osatzen dituzte, eta tokian tokiko zerealgintza-esparru nagusia izan dira topografia malkarrak baldintzatutako inguruetan. Gisa honetan, terraza-sistemak landa-paisaiaren giltzarri gisa uler daitezke, haien bilakaera historikoaren ikerketari bidea irekiz.
Sunbillako etxe-izenak eliz atariko hilarrietan
Authors: Colomo Koldo
Published: March 2022

Sunbillako Done Joane Bataiatzailearen parrokiako eliz atarian hilobi­lauza epigrafia­tuak daude. Idazkunen ikerketaren bidez, berrogeita zazpi etxe­izen bildu eta kronolo­gia orokorra proposatu da.
Efecto de las hormonas tiroideas sobre la secreción de insulina y el metabolismo de los islotes de Langerhans
Authors:   , Cortizo Ana María
Published: March 2022

El rol de las hormonas tiroideas en la diabetes mellitus y la función endocrina del páncreas fue estudiado por primera vez en 1944 por B. A. Houssay. Trabajando con perros parcialmente pancreatectomizados, sometidos a tratamiento con hormonas tiroideas, observó que adquirían una forma de diabetes irreversible, que persistía aun después de interrumpir el tratamiento tiroideo. Llamó a esta Diabetes Metatiroidea; su mecanismo parecía ser un agotamiento pancreático consecutivo a una sobreestimulación. Sus estudios se extendieron en animales sometidos a tiroidectomía y pancreatectomía subtotal simultánea, observando que no se reducía la severidad de la diabetes, sino que la operación exacerbaba lo s síntomas, la enfermedad progresaba más rápidamente y finalmente morían en hipoglucemia. A partir de estos experimentos, las hormonas tiroideas han sido consideradas como hormonas diabetogénicas. Numerosos investigadores han observado la intolerancia a la glucosa asociada con una disfunción tiroidea, tanto a nivel clínico como experimental. Pero el mecanismo por el cual las hormonas tiroideas llevan a cabo estos cambios es hasta hoy desconocido.
FULL MOUTH REHABILITATION OF SEVERE FLUOROSIS CASE WITH WORN-OUT DENTITION WITH ALL- CERAMIC RESTORATION- A CASE REPORT
Authors: Sarfaraz Hasan , Dilip Nilina , Kumar Shetty Sanath , Mohammed Zahid , Tanya Tanya
Published: March 2022

Dental uorosis is the hypomineralization of the enamel due to overexposure to excessive uoride concentration during
the time of tooth development. Severe discoloration and tooth wear are the main adverse effects of this condition. This
case report describes 28 year old patient with generalized attrition of full complement of teeth with brownish discoloration , pitting and reduction
in the vertical dimension due to severe dental Fluorosis. Complete rehabilitation of entire dentition was the proposed treatment and occlusal splint
was used to increase the vertical dimension. Once the new vertical dimension was established provisional xed restoration followed by permanent
rehabilitation.The following case report proposes that a promising clinical outcome was obtained by re-establishment of the vertical dimension
with improvisation in esthetics and function.
EVALUATION OF FUNCTIONAL OUTCOME OF MODIFIED TENSION BAND WIRING AT 6 MONTHS IN ISOLATED OLECRANON FRACTURES IN ADULTS
Authors: Saha Pulak , Debroy Sankar , Panda Arnab
Published: March 2022

Introduction: Fractures of the olecranon account for 8 - 10 % of all fractures around the elbow joint . An uncomplicated
fracture of the olecranon is considered to be a common injury. Incidence in adult population is approximately 11.5% per
1 64 100000 population .Younger individuals suffer fracture olecranon due to high energy trauma and older individuals due to simple fall . When
displaced, open reduction and internal xation is usually required to obtain anatomical realignment of the articular surface and restore normal
elbow function. The xation should be stable, allow active elbow exion and extension and promote union of the fracture. There are other
modalities of xation of isolated olecranon fractures, such as olecranon hook plate and cannulated lag screws as well but tension band wiring is
less costly and operative complications are less in non comminuted olecranon fractures. Material and methods: This prospective observational
study was done over a period of 2 years on transverse and oblique fractures of olecranon. Results: the outcome of our study was favorable in
support of tension band wiring in transverse and oblique fracture of olecranon in respect to union rate, early initiation of physiotherapy and nal
range of motion. Conclusion: By this method post-operative immobilization in POP is greatly minimized. Thereby avoiding fracture
disease.Because of rigid xation between the fracture fragments, early active and functional movements can be given to the patient reducing the
chances of joint stiffness. Early initiation of physiotherapy program within 2 – 3 weeks induces compression between the fragments. This
compression hastens fracture healing. Because of early union of fracture, patient is back to work earlier
TWO BODY WEAR OF COMMONLY USED DENTAL CERAMICS AND ENAMEL”
Authors: Khandelwal Meenakshi , Punia Vikas , Sharma Vivek , Kapoor Punia Sandhya , Metgud Sandeep
Published: March 2022

Statement of Problem- Wear behaviour of a restorative materials is an important mechanical property to be considered
during selection. Dental ceramics have been the mainstay of esthetic dentistry for more than 100 years. However, dentists
remain suspicious about its potential abrasivity. Newer ceramics are being considered to be more wear friendly.
Methodology- The present study evaluated and compared the wear resistance of one conventional dental ceramic, one low fusing ceramic and
one heat pressed ceramic against human enamel. Human enamel specimens were taken as control. Wear simulation was performed in a pin on
disc wear system with 18 N load, 120 rpm speed for 20000 cycles. Wear rate and loss of height was calculated for all specimens and subjected to
one was ANOVA followed by post hoc Tukey b analysis.
Results- Ceramics exhibited lower wear rate than human enamel specimens (p<0.05). Among ceramics heat pressed ceramics showed least wear.
For antagonist wear conventional ceramics and low fusing ceramics caused similar (p>0.05) wear of enamel antagonists which was higher than
heat pressed ceramics (p<0.05).
Conclusion- Newer ceramic formulations are more wear resistant than conventional ceramics and cause less wear of opposing teeth.
“INCIDENCE AND PATTERNS OF CONGENITAL HEART DISEASES AMONG NEONATES ADMITTED IN SPECIAL NEW BORN CARE UNITS OF DISTRICT HOSPITAL NANDYAL, KURNOOL”
Authors: lalitha O. , Prasanna G.Madhavi
Published: March 2022

Objective: To nd out the pattern and incidence of congenital Heart defects among neonates in SNCU, District Hospital,
Nandyal.
Methods: This is a retrospectic hospital-based study conducted over a period of 12 months in the Special new born care unit of District Hospital,
Nandyal from 01th January 2021 to 31st December 2021. Neonates (new born up to 28 days of age) admitted are examined in the unit irrespective
of their condition comprised the study population. They were rst examined by the medical ofcer at the time of admission and subsequently by a
pediatrician. Information of gender, weight, gestational age, were recorded on a predesigned Performa. After clinical examination, relevant
investigations like ultrasonography, radiology, echocardiography, laboratory and genetic studies were done to conrm diagnosis if it was needed.
Results: Out of 2185 total admissions, 51 (2.28%) neonates were having congenital heart defect. Of them, 23 (45.1%) were male and 28
(54.90%) females. CHD was observed in 76% full-term and 24% pre-term infants. CHD was observed in 32 infants weighing >2,500 g (64% of
corresponding birth weight infants); 17 weighing 1,500 to 2,500 g (34%); and 1 weighing <1,500 g (2%). The incidence of CHD was higher in the
full-term group. However, the incidence of complex CHD in full-term neonates was high.
Conclusion: Findings from our study suggest that the recent incidence and disease pattern of CHD might have changed for both complex and
simple forms of CHD in District Hospital, Nandyal.
COMPARATIVE EVALUATION OF MARGINAL SEALING ABILITY OF POSTERIOR PACKABLE COMPOSITE WITH OR WITHOUT LINERS USING DYE PENETRATION METHOD- AN INVITRO STUDY.
Authors: Kapoor Punia Sandhya , Punia Vikas , Sharma Vivek , Khandelwal Meenakshi , Metgud Sandeep
Published: March 2022

Condensable” or “packable” composites (Surel) were introduced as an alternative to dental amalgam. However,
concerns have been raised related to the ability of these stiffer materials to adequately adapt to internal surfaces. To offset
this problem, low viscosity owable liners walls are recommended under packable composites. This study aimed at evaluating the effect of SDR
and Ketac N100 liners on marginal sealing ability of High Density Surel posterior packable composite.
Methodology: Sixty permanent extracted molars were mounted in a modelling wax and box only Class II cavities were prepared on the mesial
side with gingival seat 1mm above CEJ. Teeth were divided into 3 groups: Group (i) Surel with SDR; Group (ii) Surel with Ketac N 100; and
Group (iii) Surel without liner. After restoration, the teeth were immersed in Methylene blue dye, sectioned mesiodistally and then evaluated for
leakage under Stereomicroscope.
Results: None of the groups were free of microleakage. Surel without liner (1.2±0.696) exhibited maximum microleakage followed by Ketac
N100 group (0.9±0.718) and SDR group (0.8±0.523) showed least microleakage.
Conclusion: Posterior packable composites should be lined by a resin based liner at the gingival margin to allow better seal
EVALUATION OF SKILL ACQUISITION OF VIDEOLARYNGOSCOPY IN COMPARISON TO DIRECT LARYNGOSCOPY IN POSTGRADUATE MEDICAL STUDENTS: A MANIKIN STUDY
Authors: Archita R Patil , Arati Jadhav , Sahasrabudhe Anupama , Rishardhan Prithiv
Published: March 2022

Background: Direct laryngoscopy with Macintosh laryngoscope (ML) is the gold standard technique for tracheal
intubation. However, visualization of the larynx and subsequent tracheal intubation may not be possible in difcult
airways. TruView video laryngoscope (TVL) can provide good visualization of the glottis and visual conrmation of tracheal intubation in a
difcult airway scenario. This manikin study was carried out to compare the skill acquisition for videolaryngoscopy using TVL and compare it
with direct laryngoscopy using ML, in easy and difcult airway scenarios, in TVL novice participants.
Material and methods: Thirty resident doctors were randomized to participate in a crossover, manikin study. Participants were asked to intubate
a manikin in easy and difcult airway scenarios using TruView and Macintosh laryngoscope. Two trials were conducted at one-week interval and
at the end of each trial parameters of Intubation time, Cormack-Lehane (CL) grading, success of intubation and ease of intubation which reect
skill acquisition were recorded. All 30 participants completed the study.
Results: In the easy scenario most results were comparable between the two devices. The TVL scored over ML in all aspects of difcult
intubation with signicantly lesser time for intubation (23.27 ± 1.8sec, P<0.0001), lower CL grade (1&2-100%), higher success of intubation in
the rst attempt (83.33%, P=0.0016) and greater ease of intubation (100%, P<0.0001).
Conclusion: TVL scores over ML in difcult airway scenarios in novice users of TVL, within a short learning time.
MAN TURNING INTO WOLF-POSSIBLE?
Authors: Maiti Dipankar
Published: March 2022

Lycanthropy is the mythological aptitude or power of a human being to endure transformation into an animal alike state,
such as a werewolf. Lycanthropy is an infrequent variant of a delusional misidentication syndrome specically opposite
inter-metamorphosis where patients have faith in that they are experiencing alteration or have transformed into an animal. A case report of this
miracle is discussed. A case was reported of Clinical lycanthropy phenomenon of a 25-year-old male who whispered himself to be transformed
into a buffalo after bestiality along with developing obsessive-compulsive scenery. A case report sideways with a literature review arrangement
the basis of discussion. Clinical lycanthropy has been described with various neuropsychiatric conditions as well as primary psychotic and
affective conditions, drug intoxication and extraction, cerebrovascular disease, traumatic brain injury, dementia, delirium, and seizures, but its
connotation in the context of obsessive-compulsive and related disorders (OCRDs) is a very rare nding. A variance of OCRD should be given due
reputation and managed accordingly when dealing with lycanthropy, which may help in early identication and management.
MANAGEMENT OF PRESSURE URTICARIA (SHĪTPITTA) THROUGH VIRECANA : A CASE REPORT
Authors: Kathait Rashmi , Pandey Ajai Kumar
Published: March 2022

Introduction: A 32 years old female patient consulted for the following complaints- frequent episodes of papular,
pinkish red rashes on whole body on applying pressure or scratching, associated with marked itching and burning
sensation since one and a half month. She was clinically diagnosed as acute case of Shītpitta that can be correlated with urticaria (pressure
urticaria: due to pressure).
Material and Methods: Ayurvedic Śodhana (Virecana) and Śamana treatment were used to successfully manage this condition. The goal of this
case study is to illustrate how Śodhana (bio-purication treatments) and Śamana (palliative) therapy might be benecial in the treatment of
allergic disorders such as urticaria.
Result and Conclusion: After receiving Virecana and oral medication, the patient's symptoms considerably improved. Although contemporary
medicine offers a variety of treatment options for urticaria and other allergic skin conditions, recurrence is typical even after medication. This case
study shown that Ayurvedic management (Virecana as Śodhana therapy and Śamana āusadha) may be useful in the treatment of skin issues.
SURGICAL TREATMENT OF PILON FRACTURES BY DELTA-EXTERNAL FIXATOR VERSUS MIPPO – A CLINICAL STUDY
Authors: V Mudgal Chandrashekar , Ramanand Madhuchandra , Harnalli Anoop
Published: March 2022

BACKGROUND : The treatment of Pilon fractures are among the most dreaded of all ankle joint fractures, and they
continue to pose a challenge to the trauma surgeon. They are associated with substantial soft tissue damage, articular
surface disturbance, and osseous comminution. The optimal management of pilon fractures and the ideal treatment for these fractures are still
debatable.
Aim:The aim of this study was to analyze the functional outcome of patients with Pilon fractures treated by Delta External Fixator versus MIPPO.
Results: Among the 26 patients(19 male and 7 female). included in the study, followed for a minimum period of 6 months, outcome was excellent
in the Delta External xator group than in ORIF group. Although the nal AOFAS score and ROM was slightly less in Delta External xator
group, the time to weight bearing and time to radiological union were slightly shorter in Delta External xator group than ORIF group in our study.
MIS-C A RETROSPECTIVE OBSERVATIONAL STUDY FROM TERTIARY CARE CENTERS OF PURVANCHAL AREA OF EASTERN U.P. AND ADJACENT SOUTH BIHAR.
Authors: Srivastava Sandesh , Kumar Rahul , Karan Sonam , Kumar Ritesh , Raghuvanshi Udit , Bhattacharya Roshni , Singh Om Prakash
Published: March 2022

Objective:We are describing the temporal prole of 19 cases of MIS-C including demographic, clinical and laboratory
ndings along with the treatment and outcomes .We also studied the response to various available treatment modalities
for MIS-C.
Method: This was a retrospective observational study carried out at a tertiary care center . Children satisfying WHO MIS-C criteria admitted
from Apr 2021 to Aug 2021 to PICU were included. The clinical prole, treatment, laboratory parameters and outcomes in all 19 critically ill
children diagnosed with MIS-C were analyzed from Apr 2021 to Aug 2021.
Results: The study population in this study included 19 patients with MIS-C . All 19 children had fever,15 of them had gastrointestinal features.
Hypotension was observed in 12 cases. Eye changes in the form of conjunctival congestion, conjunctivitis,& conjunctival hemorrhage was
observed in 14 children. Most of them were treated with steroids alone, Few of them required steroids as well as IVIg. There was no treatment
failure observed in any of the cases. There was a gradual reduction of the CRP by day 3 in most of the cases.. Follow up studies have not revealed
any abnormality on echocardiography
Conclusion:Steroids were found to be equally effective & were the rst line of management in all the cases. IVIG was used in cases which were
subjected to mechanical ventilation in children with SARS-CoV-2 related MIS-C. There was no mortality in this group