bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of the Homogenization Pressure on the Rheology of Biopolymer-Stabilized Emulsions Formulated with Thyme Oil
Authors: Trujillo-Cayado Luis A. , Santos Jenifer , Calero Nuria , Alfaro Maria del Carmen , Muñoz José
Published: February 2019

Different continuous phases formulated with ecofriendly ingredients such as AMIDET® N, an ecological surfactant, as well as welan and rhamsan gums were developed. An experimental design strategy was been in order to study the influence of the ratio of these two polysaccharides and the homogenization pressure applied in a microfluidizer on the critical shear stress for the continuous phases developed. A pure rhamsan gum solution was selected as the starting point for further study based on the production of thyme oil-in-water emulsions. The effect of the homogenization pressure on the physical stability, critical shear stress and droplet size distribution was analyzed for emulsions with optimized values of the rhamsan–welan ratio. These bioactive thyme oil-in-water emulgels could be considered as delivery systems with potential applications in the food industry.
Thin-Film Flow of an Inhomogeneous Fluid with Density-Dependent Viscosity
Authors: Fusi Lorenzo , Farina Angiolo , Rosso Fabio , Rajagopal Kumbakonam
Published: February 2019

In this paper, we study the pressure-driven thin film flow of an inhomogeneous incompressible fluid in which its viscosity depends on the density. The constitutive response of this class of fluids can be derived using a thermodynamical framework put into place to describe the dissipative response of materials where the materials’ stored energy depends on the gradient of the density (Mechanics of Materials, 2006, 38, pp. 233–242). Assuming a small aspect ratio for the channel, we use the lubrication approximation and focus on the leading order problem. We show the mathematical problem reduce to a nonlinear first order partial differential equation (PDE) for the density in which the coefficients are integral operators. The problem is solved numerically and plots that describe the evolution of the density in the fluid domain are displayed. We also show that it was possible to determine an analytical solution of the problem when the boundary data are small perturbations of the homogeneous case. Finally, we use such an analytical solution to validate the numerical scheme.
Genetic Epidemiology of Breast Cancer in Latin America
Authors: Zavala Valentina A. , Serrano-Gomez Silvia J. , Dutil Julie , Fejerman Laura
Published: February 2019

The last 10 years witnessed an acceleration of our understanding of what genetic factors underpin the risk of breast cancer. Rare high- and moderate-penetrance variants such as those in the BRCA genes account for a small proportion of the familial risk of breast cancer. Low-penetrance alleles are expected to underlie the remaining heritability. By now, there are about 180 genetic polymorphisms that are associated with risk, most of them of modest effect. In combination, they can be used to identify women at the lowest or highest ends of the risk spectrum, which might lead to more efficient cancer prevention strategies. Most of these variants were discovered in populations of European descent. As a result, we might be failing to discover additional polymorphisms that could explain risk in other groups. This review highlights breast cancer genetic epidemiology studies conducted in Latin America, and summarizes the information that they provide, with special attention to similarities and differences with studies in other populations. It includes studies of common variants, as well as moderate- and high-penetrance variants. In addition, it addresses the gaps that need to be bridged in order to better understand breast cancer genetic risk in Latin America.
Identification of Differentially Expressed Genes and Pathways for Abdominal Fat Deposition in Ovariectomized and Sham-Operated Chickens
Authors: Mu Xiaopeng , Cui Xiaoyan , Liu Ranran , Li Qinghe , Zheng Maiqing , Zhao Guiping , Ge Changrong , Wen Jie , Hu Yaodong , Cui Huanxian
Published: February 2019

Ovariectomy results in improved meat quality (growth rate, tenderness, and flavor) of broilers. However, some negative effects increased (abdominal fat (AF) deposition, low feed conversion, etc.) have also been reported. In this study, the gene expression profiles of AF tissue in ovariectomized and sham-operated chickens were determined to identify differentially expressed genes (DEGs) and pathways to explore the molecular mechanisms underlying AF accumulation. Comparing the ovariectomized group and the sham-operated group, the abdominal fat weight (AFW) and abdominal fat percentage (AFP) were increased significantly (p < 0.05) at 14 and 19 weeks after ovariectomy. According to the gene expression profiling analysis, 108 DEGs of fat metabolism were screened from 1461 DEGs. Among them, ABCA1, ABCACA, LPL, CREB1, PNPLA2, which are involved in glycerolipid—or steroid—associated biological processes, and the hormone receptor genes, ESR1 and PRLR, were down-regulated significantly in the ovariectomized group compared to the sham-operated group (p < 0.05). Conversely, CETP, DGAT2, DHCR24, HSD17B7 and MSMO1, were significantly up-regulated (p < 0.05) after ovariectomy. Based on the DEGs, the glycerolipid metabolism, steroid biosynthesis, and other signaling pathways (MAPK, TGF-β, and adhesion pathways, etc.) were enriched, which may also contribute to the regulation of AF deposition. Our data suggest that AF deposition was significantly increased in ovariectomized chickens by the down-regulation of the decomposition genes of glycerolipid metabolism, which inhibits AF degradation, and the up-regulation of steroid biosynthesis genes, which increases fat accumulation. These findings provide new insights into the molecular mechanisms of fat deposition in the ovariectomized chickens.
Modeling of GRACE-Derived Groundwater Information in the Colorado River Basin
Authors: Rahaman Md , Thakur Balbhadra , Kalra Ajay , Ahmad Sajjad
Published: February 2019

Groundwater depletion has been one of the major challenges in recent years. Analysis of groundwater levels can be beneficial for groundwater management. The National Aeronautics and Space Administration’s twin satellite, Gravity Recovery and Climate Experiment (GRACE), serves in monitoring terrestrial water storage. Increasing freshwater demand amidst recent drought (2000–2014) posed a significant groundwater level decline within the Colorado River Basin (CRB). In the current study, a non-parametric technique was utilized to analyze historical groundwater variability. Additionally, a stochastic Autoregressive Integrated Moving Average (ARIMA) model was developed and tested to forecast the GRACE-derived groundwater anomalies within the CRB. The ARIMA model was trained with the GRACE data from January 2003 to December of 2013 and validated with GRACE data from January 2014 to December of 2016. Groundwater anomaly from January 2017 to December of 2019 was forecasted with the tested model. Autocorrelation and partial autocorrelation plots were drawn to identify and construct the seasonal ARIMA models. ARIMA order for each grid was evaluated based on Akaike’s and Bayesian information criterion. The error analysis showed the reasonable numerical accuracy of selected seasonal ARIMA models. The proposed models can be used to forecast groundwater variability for sustainable groundwater planning and management.
Application of a Sequential Extraction Method for Analyzing Cu Distribution in Pre-Treated Mine Tailings after Electrodialytic Remediation
Authors: Lazo Andrea , Hansen Henrik K. , Lazo Pamela , Gutiérrez Claudia
Published: February 2019

Mine tailings have been analyzed by a sequential extraction procedure after their pre-treatment with a leaching solution for 24 h and electrodialytic remediation during 15 days with a constant electric field of 2.7 V cm−1. Four leaching solutions were tested: H2SO4 + HNO3 (2:1 vol.) pH = 1.9; H2SO4 + HNO3 (2:1 vol) pH = 4.2; NH4Cl 0.8M, pH = 5.5 and 30% H2O2 adjusted to pH 2 with HNO3 1M + HCl 1M. After the treatment, the tailings were divided in six slices from anode to cathode. The highest removal efficiency of copper was obtained with H2SO4 + HNO3 pH = 1.9, which allows one to remove 67% of the copper in the total cell and 85% of the copper in the slice closest to anode. The same solution with pH = 4.2 allows one to remove 62% of the total copper. The analysis realized by the sequential extraction method indicates the easy removal of water-soluble and exchangeable fractions in all experiments, moreover, residual and sulfide are the less mobile fractions. The general trend was the movement of copper associated to different fractions from anode to cathode and its accumulation closest to the cathode in the case of exchangeable, Fe-Mn oxides and acid soluble fractions, possibly due to some precipitation of copper compounds associated with less acidic conditions.
From Science to Policy and Practice: A Critical Assessment of Knowledge Management before, during, and after Environmental Public Health Disasters
Authors: Généreux Mélissa , Lafontaine Marc , Eykelbosh Angela
Published: February 2019

Canada regularly faces environmental public health (EPH) disasters. Given the importance of evidence-based, risk-informed decision-making, we aimed to critically assess the integration of EPH expertise and research into each phase of disaster management. In-depth interviews were conducted with 23 leaders in disaster management from Canada, the United States, the United Kingdom, and Australia, and were complemented by other qualitative methods. Three topics were examined: governance, knowledge creation/translation, and related barriers/needs. Data were analyzed through a four-step content analysis. Six critical success factors emerged from the analysis: blending the best of traditional and modern approaches; fostering community engagement; cultivating relationships; investing in preparedness and recovery; putting knowledge into practice; and ensuring sufficient human and financial resources. Several promising knowledge-to-action strategies were also identified, including mentorship programs, communities of practice, advisory groups, systematized learning, and comprehensive repositories of tools and resources. There is no single roadmap to incorporate EPH expertise and research into disaster management. Our findings suggest that preparation for and management of EPH disaster risks requires effective long-term collaboration between science, policy, and EPH practitioners at all levels in order to facilitate coordinated and timely deployment of multi-sectoral/jurisdictional resources when and where they are most needed.
Sub-lethal Doses of Polybrominated Diphenyl Ethers, in Vitro, Promote Oxidative Stress and Modulate Molecular Markers Related to Cell Cycle, Antioxidant Balance and Cellular Energy Management
Authors: Manuguerra Simona , Espinosa Ruiz Cristóbal , Santulli Andrea , Messina Concetta Maria
Published: February 2019

In the present study, we evaluated the effects of different concentrations of the polybrominated diphenyl ethers (PBDEs) BDE-209, BDE-47 and BDE-99, on the vitality and oxidative stress of a HS-68 human cell culture exposed to the compounds for three days. The results showed that for this exposure time, only the highest concentrations produced a significant vitality reduction and oxidative stress induction (p < 0.05), measured as reactive oxygen species (ROS). Subsequently, in order to verify the effects of sub-lethal doses, cells were exposed for a longer time and data collected, after 12 and 20 days, to study ROS production and some molecular markers related to cell cycle and stress (p53, pRB, PARP, c-Jun and c-Fos), antioxidant status and proliferation (ERK, c-Jun and c-Fos), energy balance (NRF2, AMPK, HIF). Most of the biomarkers were influenced by the treatments, indicating that sub-lethal doses of PBDEs, for longer time, can enhance the production of ROS, altering the energetic metabolism, cell cycle and antioxidant balance, determining possible negative effects on the cell proliferation equilibrium.
A Comparative Study of Statistics-Based Landslide Susceptibility Models: A Case Study of the Region Affected by the Gorkha Earthquake in Nepal
Authors: Meena Sansar Raj , Ghorbanzadeh Omid , Blaschke Thomas
Published: February 2019

As a result of the Gorkha earthquake in 2015, about 9000 people lost their lives and many more were injured. Most of these losses were caused by earthquake-induced landslides. Sustainable planning and decision-making are required to reduce the losses caused by earthquakes and related hazards. The use of remote sensing and geographic information systems (GIS) for landslide susceptibility mapping can help planning authorities to prepare for and mitigate the consequences of future hazards. In this study, we developed landslide susceptibility maps using GIS-based statistical models at the regional level in central Nepal. Our study area included the districts affected by landslides after the Gorkha earthquake and its aftershocks. We used the 23,439 landslide locations obtained from high-resolution satellite imagery to evaluate the differences in landslide susceptibility using analytical hierarchy process (AHP), frequency ratio (FR) and hybrid spatial multi-criteria evaluation (SMCE) models. The nine landslide conditioning factors of lithology, land cover, precipitation, slope, aspect, elevation, distance to roads, distance to drainage and distance to faults were used as the input data for the applied landslide susceptibility mapping (LSM) models. The spatial correlation of landslides and these factors were identified using GIS-based statistical models. We divided the inventory into data used for training the statistical models (70%) and data used for validation (30%). Receiver operating characteristics (ROC) and the relative landslide density index (R-index) were used to validate the results. The area under the curve (AUC) values obtained from the ROC approach for AHP, FR and hybrid SMCE were 0.902, 0.905 and 0.91, respectively. The index of relative landslide density, R-index, values in sample datasets of AHP, FR and hybrid SMCE maps were 53%, 58% and 59% for the very high hazard classes. The final susceptibility results will be beneficial for regional planning and sustainable hazard mitigation.
Bidirectional Face Aging Synthesis Based on Improved Deep Convolutional Generative Adversarial Networks
Authors: Liu Xinhua , Zou Yao , Xie Chengjuan , Kuang Hailan , Ma Xiaolin
Published: February 2019

The use of computers to simulate facial aging or rejuvenation has long been a hot research topic in the field of computer vision, and this technology can be applied in many fields, such as customs security, public places, and business entertainment. With the rapid increase in computing speeds, complex neural network algorithms can be implemented in an acceptable amount of time. In this paper, an optimized face-aging method based on a Deep Convolutional Generative Adversarial Network (DCGAN) is proposed. In this method, an original face image is initially mapped to a personal latent vector by an encoder, and then the personal potential vector is combined with the age condition vector and the gender condition vector through a connector. The output of the connector is the input of the generator. A stable and photo-realistic facial image is then generated by maintaining personalized facial features and changing age conditions. With regard to the objective function, the single adversarial loss of the Generated Adversarial Network (GAN) with the perceptual similarity loss is replaced by the perceptual similarity loss function, which is the weighted sum of adversarial loss, feature space loss, pixel space loss, and age loss. The experimental results show that the proposed method can synthesize an aging face with rich texture and visual reality and outperform similar work.
Long-Term Safety and Real-World Effectiveness of Trastuzumab in Breast Cancer
Authors: Mazzotta Marco , Krasniqi Eriseld , Barchiesi Giacomo , Pizzuti Laura , Tomao Federica , Barba Maddalena , Vici Patrizia
Published: February 2019

Trastuzumab is a milestone in the treatment of human epidermal growth factor receptor 2 positive (HER2+) breast cancer (BC), in both the early and metastatic settings. Over the last two decades, clinical trials have established the good safety profile of trastuzumab. Cardiotoxicity remains the most frequent adverse event, more commonly exemplified by an asymptomatic decline in the left ventricular ejection fraction rather than congestive heart failure. Results from several long-term (>5 years) safety analyses have been recently published, with the inherent evidence substantially confirming the findings from previous trials. The clinical experience gained over the years in the use of trastuzumab has also fueled a number of observational studies focused on the effectiveness of this drug in the real-world settings. We herein reviewed the evidence available from tree major databases, namely, PubMed, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL), to explore and critically discuss key issues related to the long-term safety and effectiveness of trastuzumab in clinical practice.
Coronary Physiology in the Cardiac Catheterization Laboratory
Authors: Shah Samit M. , Pfau Steven E.
Published: February 2019

Coronary angiography has been the principle modality for assessing the severity of atherosclerotic coronary artery disease for several decades. However, there is a complex relationship between angiographic coronary stenosis and the presence or absence of myocardial ischemia. Recent technological advances now allow for the assessment of coronary physiology in the catheterization laboratory at the time of diagnostic coronary angiography. Early studies focused on coronary flow reserve (CFR) but more recent work has demonstrated the physiologic accuracy and prognostic value of the fractional flow reserve (FFR) and instantaneous wave free ratio (iFR) for the assessment of coronary artery disease. These measurements have been validated in large multi-center clinical trials and have become indispensable tools for guiding revascularization in the cardiac catheterization laboratory. The physiological assessment of chest pain in the absence of epicardial coronary artery disease involves coronary thermodilution to obtain the index of microcirculatory resistance (IMR) or Doppler velocity measurement to determine the coronary flow velocity reserve (CFVR). Physiology-based coronary artery assessment brings “personalized medicine” to the catheterization laboratory and allows cardiologists and referring providers to make decisions based on objective findings and evidence-based treatment algorithms. The purpose of this review is to describe the theory, technical aspects, and relevant clinical trials related to coronary physiology assessment for an intended audience of general medical practitioners.
Kidney Involvement in Patients with Type 1 Autoimmune Pancreatitis
Authors: Vujasinovic Miroslav , Pozzi Mucelli Raffaella Maria , Valente Roberto , Verbeke Caroline Sophie , Haas Stephan L. , Löhr J.-Matthias
Published: February 2019

Introduction: Autoimmune pancreatitis (AIP) type 1 is a special form of chronic pancreatitis with a strong lymphocytic infiltration as the pathological hallmark and other organ involvement (OOI). IgG4-related kidney disease (IgG4-RKD) was first reported as an extrapancreatic manifestation of AIP in 2004. The aim of the present study was to determine the frequency and clinical impact of kidney lesions observed in patients with AIP type 1. Methods: We performed a single-centre retrospective study on a prospectively collected cohort of patients with a histologically proven or highly probable diagnosis of AIP according to the International Consensus Diagnostic Criteria (ICDC) classification. Results: Seventy-one patients with AIP were evaluated. AIP type 1 was diagnosed in 62 (87%) patients. Kidney involvement was present in 17 (27.4%) patients with AIP type 1: 15 (88.2%) males and 2 (11.8%) females. Laboratory and/or imaging signs of kidney involvement were presented at the time of AIP diagnosis in eight (47.1%) patients. In other patients, the onset of kidney involvement occurred between four months and eight years following diagnosis. At the time of the diagnosis of kidney involvement, eight (47.1%) patients showed elevated creatinine, and nine (52.9%) patients showed normal serum creatinine. None of the patients were treated with dialysis. Conclusions: IgG4-RKD was present in 27.4% of patients with AIP type 1, with male gender predominance. In cases of early diagnosis and cortisone treatment, the clinical course was mild in most cases. Regular laboratory control of renal function should be a part of the follow-up of patients with AIP type 1.
Secure and Reliable IoT Networks Using Fog Computing with Software-Defined Networking and Blockchain
Authors: Muthanna Ammar , A. Ateya Abdelhamied , Khakimov Abdukodir , Gudkova Irina , Abuarqoub Abdelrahman , Samouylov Konstantin , Koucheryavy Andrey
Published: February 2019

Designing Internet of Things (IoT) applications faces many challenges including security, massive traffic, high availability, high reliability and energy constraints. Recent distributed computing paradigms, such as Fog and multi-access edge computing (MEC), software-defined networking (SDN), network virtualization and blockchain can be exploited in IoT networks, either combined or individually, to overcome the aforementioned challenges while maintaining system performance. In this paper, we present a framework for IoT that employs an edge computing layer of Fog nodes controlled and managed by an SDN network to achieve high reliability and availability for latency-sensitive IoT applications. The SDN network is equipped with distributed controllers and distributed resource constrained OpenFlow switches. Blockchain is used to ensure decentralization in a trustful manner. Additionally, a data offloading algorithm is developed to allocate various processing and computing tasks to the OpenFlow switches based on their current workload. Moreover, a traffic model is proposed to model and analyze the traffic indifferent parts of the network. The proposed algorithm is evaluated in simulation and in a testbed. Experimental results show that the proposed framework achieves higher efficiency in terms of latency and resource utilization.
Terahertz Time Domain Spectroscopy to Detect Different Oxidation Levels of Diesel Engine Oil
Authors: Abdul-Munaim Ali Mazin , Ornik Jan , Koch Martin , Watson Dennis G.
Published: February 2019

Diesel engine oil was subjected to thermal oxidization (TO) for six periods of time (0 h, 24 h, 48 h, 72 h, 96 h, and 120 h) and was subsequently characterized by terahertz time domain spectroscopy (THz-TDS). The THz refractive index generally increased with oxidation time. The measurement method illustrated the potential of THz-TDS when a fixed setup with a single cuvette is used. A future miniaturized setup installed in an engine would be an example of a fixed setup. For the refractive index, there were highly significant differences among the oxidation times across most of the 0.3–1.7 THz range.
Investigation of Fused Alumina Based-Mold Facecoats for DZ22B Directionally Solidified Blades
Authors: Li Fei , Ni Hongjun , Yang Lixiang , Jiang Yi , Wang Donghong , Sun Baode
Published: February 2019

The interaction between alloy melt and mold facecoats is the main factor affecting the surface quality of investment casting nickel-based superalloys. An investigation was undertaken to develop suitable refractories as facecoat materials for the directionally solidified blades of DZ22B nickel-based superalloys in order to avoid a sand-burning defect. The wettability and interface reactions between alloy melt and various facecoats were studied by using a sessile drop experiment and the real investment casting method, respectively. The results show that by adding Cr2O3 powder with the amounts of 2 wt.%, 5 wt.% and 10 wt.% in the fused alumina-based facecoats, the wetting angles between the alloy melt and facecoats decreased from 105.40° to 100.37°, 99.96° and 98.11°, respectively, while the sand-burning defect on the casting blade surfaces still formed during the process of directional solidification. However, by adding h-BN powder in the fused alumina-based facecoats, the wetting angles between the alloy melt and facecoats dramatically increased, the sand-burning defect on the casting blade surfaces was effectively inhibited and a metallic luster on the directionally solidified blades could be obviously observed. In this study, the suitable composition of mold facecoats for the investment casting of blades is 2 wt.% h-BN added fused alumina.
Understanding Free Volume Characteristics of Ethylene-Propylene-Diene Monomer (EPDM) through Molecular Dynamics Simulations
Authors: Wang Yajian , Yang Yuyou , Tao Mingjiang
Published: February 2019

Understanding the underlying processes associated with the viscoelasticity performance of ethylene-propylene-diene monomer (EPDM) during its service life is essential for assessing and predicting its waterproofing performance in underground infrastructure. The viscoelasticity of the polymer is closely related to its free volume, and both of these properties depend on multiple factors, such as temperature, stress magnitude, and strain level. To explore the fundamental viscoelastic behavior of EPDM using free volume as a proxy for viscoelasticity, this article investigates the influence of temperature, stress magnitude, and strain level, as well as their combined effect, on the free volume through molecular dynamics (MD) simulations. An EPDM cross-linked molecular model was built and verified by comparing the simulation values of glass transition temperature, mechanical properties, and gas diffusivity with the experimental results reported in the literature. Then, the dependence of EPDM’s fractional free volume on temperature, strain, and their combined effect was investigated via MD simulations, on the basis of which the applicability of various superposition principles was also evaluated.
The Supramolecular Organogel Formed by Self-Assembly of Ursolic Acid Appended with Aromatic Rings
Authors: Lu Jinrong , Hu Jinshan , Liang Yinghua , Cui Wenquan
Published: February 2019

Ursolic acid (UA) as a natural ursane-triterpenoid has rich pharmacological activities. We have found that it possesses aggregation properties and could self-assemble into organogels. Based on the aggregation property of ursolic acid in suitable solvents, its derivative appended with aromatic rings by amide groups was synthesized. The property of self-assembly into organogel was studied in this paper. The results revealed that this derivative could form supramolecular gel in halogenated benzene and also gelate chloroform in the presence of toluene or p-xylene. By Fourier-transform infrared spectra (FT-IR) and variable temperature proton nuclear magnetic resonance (1H NMR), it was proved that intermolecular hydrogen bonding and π–π stacking interaction were the primary driving forces for the aggregation to form organogel.
Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called “Telocytopathies”
Authors: Varga Ivan , Polák Štefan , Kyselovič Ján , Kachlík David , Danišovič Ľuboš , Klein Martin
Published: February 2019

In recent years, the interstitial cells telocytes, formerly known as interstitial Cajal-like cells, have been described in almost all organs of the human body. Although telocytes were previously thought to be localized predominantly in the organs of the digestive system, as of 2018 they have also been described in the lymphoid tissue, skin, respiratory system, urinary system, meninges and the organs of the male and female genital tracts. Since the time of eminent German pathologist Rudolf Virchow, we have known that many pathological processes originate directly from cellular changes. Even though telocytes are not widely accepted by all scientists as an individual and morphologically and functionally distinct cell population, several articles regarding telocytes have already been published in such prestigious journals as Nature and Annals of the New York Academy of Sciences. The telocyte diversity extends beyond their morphology and functions, as they have a potential role in the etiopathogenesis of different diseases. The most commonly described telocyte-associated diseases (which may be best termed “telocytopathies” in the future) are summarized in this critical review. It is difficult to imagine that a single cell population could be involved in the pathogenesis of such a wide spectrum of pathological conditions as extragastrointestinal stromal tumors (“telocytomas”), liver fibrosis, preeclampsia during pregnancy, tubal infertility, heart failure and psoriasis. In any case, future functional studies of telocytes in vivo will help to understand the mechanism by which telocytes contribute to tissue homeostasis in health and disease.
High-G Calibration Denoising Method for High-G MEMS Accelerometer Based on EMD and Wavelet Threshold
Authors: Lu Qing , Pang Lixin , Huang Haoqian , Shen Chong , Cao Huiliang , Shi Yunbo , Liu Jun
Published: February 2019

High-G MEMS accelerometers have been widely used in monitoring natural disasters and other fields. In order to improve the performance of High-G MEMS accelerometers, a denoising method based on the combination of empirical mode decomposition (EMD) and wavelet threshold is proposed. Firstly, EMD decomposition is performed on the output of the main accelerometer to obtain the intrinsic mode function (IMF). Then, the continuous mean square error rule is used to find energy cut-off point, and then the corresponding high frequency IMF component is denoised by wavelet threshold. Finally, the processed high-frequency IMF component is superposed with the low-frequency IMF component, and the reconstructed signal is denoised signal. Experimental results show that this method integrates the advantages of EMD and wavelet threshold and can retain useful signals to the maximum extent. The impact peak and vibration characteristics are 0.003% and 0.135% of the original signal, respectively, and it reduces the noise of the original signal by 96%.
Residual Stress in Lithium Niobate Film Layer of LNOI/Si Hybrid Wafer Fabricated Using Low-Temperature Bonding Method
Authors: Takigawa Ryo , Tomimatsu Toru , Higurashi Eiji , Asano Tanemasa
Published: February 2019

This paper focuses on the residual stress in a lithium niobate (LN) film layer of a LN-on-insulator (LNOI)/Si hybrid wafer. This stress originates from a large mismatch between the thermal expansion coefficients of the layers. A modified surface-activated bonding method achieved fabrication of a thin-film LNOI/Si hybrid wafer. This low-temperature bonding method at 100 °C showed a strong bond between the LN and SiO2 layers, which is sufficient to withstand the wafer thinning to a LN thickness of approximately 5 μm using conventional mechanical polishing. Using micro-Raman spectroscopy, the residual stress in the bonded LN film in this trilayered (LN/SiO2/Si) structure was investigated. The measured residual tensile stress in the LN film layer was approximately 155 MPa, which was similar to the value calculated by stress analysis. This study will be useful for the development of various hetero-integrated LN micro-devices, including silicon-based, LNOI-integrated photonic devices.
Physicochemical Properties and Cellular Uptake of Astaxanthin-Loaded Emulsions
Authors: Shen Xue , Fang Tianqi , Zheng Jian , Guo Mingruo
Published: February 2019

Astaxanthin, a natural pigment carotenoid, is well known for its potential benefits to human health. However, its applications in the food industry are limited, due to its poor water-solubility and chemical instability. Six different emulsifiers were used to prepare astaxanthin-loaded emulsions, including whey protein isolate (WPI), polymerized whey protein (PWP), WPI-lecithin, PWP-lecithin, lecithin, and Tween20. The droplet size, zeta potential, storage stability, cytotoxicity, and astaxanthin uptake by Caco-2 cells were all investigated. The results showed that the droplet size of the emulsions ranged from 194 to 287 nm, depending on the type of emulsifier used. The entrapment efficiency of astaxanthin was as high as 90%. The astaxanthin-loaded emulsions showed good physicochemical stability during storage at 4 °C. The emulsifier type had a significant impact on the degradation rate of astaxanthin (p < 0.05). Cellular uptake of astaxanthin encapsulated into the emulsions was significantly higher than free astaxanthin (p < 0.05). Emulsion stabilized with WPI had the highest cellular uptake of astaxanthin (10.0 ± 0.2%), followed, in order, by that with PWP (8.49 ± 0.1%), WPI-lecithin (5.97 ± 0.1%), PWP-lecithin (5.05 ± 0.1%), lecithin (3.37 ± 0.2%), and Tween 20 (2.1 ± 0.1%). Results indicate that the whey protein-based emulsion has a high potential for improving the cellular uptake of astaxanthin.
Correlated Electronic Properties of a Graphene Nanoflake: Coronene
Authors: Prodhan Suryoday , Mazumdar Sumit , Ramasesha S.
Published: February 2019

We report studies of the correlated excited states of coronene and substituted coronene within the Pariser–Parr–Pople (PPP) correlated

π

-electron model employing the symmetry-adapted density matrix renormalization group technique. These polynuclear aromatic hydrocarbons can be considered as graphene nanoflakes. We review their electronic structures utilizing a new symmetry adaptation scheme that exploits electron-hole symmetry, spin-inversion symmetry, and end-to-end interchange symmetry. The study of the electronic structures sheds light on the electron correlation effects in these finite-size graphene analogues, which diminishes going from one-dimensional to higher-dimensional systems, yet is significant within these finite graphene derivatives.
Multicharged Phthalocyanines as Selective Ligands for G-Quadruplex DNA Structures
Authors: Ramos Catarina I. V. , Almeida Susana P. , Lourenço Leandro M. O. , Pereira Patrícia M. R. , Fernandes Rosa , Faustino M. Amparo F. , Tomé João P. C. , Carvalho Josué , Cruz Carla , Neves M. Graça P. M. S.
Published: February 2019

The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited proliferation of cancer cells. To assess the potential of a compound as a telomerase inhibitor, selectivity for quadruplex over duplex DNA is a fundamental attribute, as the drug must be able to recognize quadruplex DNA in the presence of a large amount of duplex DNA, in the cellular nucleus. By using different spectroscopic techniques, such as ultraviolet-visible, fluorescence and circular dichroism, this work evaluates the potential of a series of multicharged phthalocyanines, bearing four or eight positive charges, as G-Quadruplex stabilizing ligands. This work led us to conclude that the existence of a balance between the number and position of the positive charges in the phthalocyanine structure is a fundamental attribute for its selectivity for G-Quadruplex structures over duplex DNA structures. Two of the studied phthalocyanines, one with four peripheral positive charges (ZnPc1) and the other with less exposed eight positive charges (ZnPc4) showed high selectivity and affinity for G-Quadruplex over duplex DNA structures and were able to accumulate in the nucleus of UM-UC-3 bladder cancer cells.
New Metabolic Influencer on Oxytocin Release: The Ghrelin
Authors: Szabó Renáta , Ménesi Rudolf , H. Molnár Andor , Szalai Zita , Daruka Lejla , Tóth Gábor , Gardi János , Gálfi Márta , Börzsei Denise , Kupai Krisztina , Juhász Anna , Radács Marianna , László Ferenc , Varga Csaba , Pósa Anikó
Published: February 2019

Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [d-Lys3]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [d-Lys3]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.
New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients
Authors: Armon-Omer Ayelet , Waldman Chen , Simaan Naaem , Neuman Hadar , Tamir Snait , Shahien Radi
Published: February 2019

Background: Multiple sclerosis (MS) is a multifactorial disease with unknown etiology. It is assumed to result from interplay between genetic and environmental factors, including nutrition. We hypothesized that there are differences in nutritional parameters between MS patients and healthy controls. Methods: We examined 63 MS patients and 83 healthy controls. Nutritional status was determined by a dietary questionnaire, blood tests, quantification of cell membrane fatty acids, and serum antioxidant capacity. Results: We found that MS patients consumed a more limited diet compared with the healthy group, indicated by a lower average of 31 nutrients and by consumption levels of zinc and thiamine below the recommended daily intake. Both consumption and measured iron values were significantly lower in MS patients, with the lowest measures in the severe MS group. Long saturated fatty acids (>C16) were significantly lower in MS patients, while palmitic and palmitoleic acids were both higher. Serum total antioxidant capacity was significantly lower in the MS group compared with healthy controls, with the lowest measures in patients with severe MS. Conclusions: This study points to a possible correlation between nutritional status and MS. Understanding the clinical meaning of these findings will potentially allow for the development of future personalized dietary interventions as part of MS treatment.
Antimony Removal from Water by a Chitosan-Iron(III)[ChiFer(III)] Biocomposite
Authors: Lapo Byron , Demey Hary , Carchi Tanya , Sastre Ana
Published: February 2019

The presence of antimony(III) in water represents a worldwide concern, mainly due to its high toxicity and carcinogenicity potential. It can be separated from water by the use of sustainable biopolymers such as chitosan or its derivatives. The present study applied chitosan modified with iron(III) beads to Sb(III) removal from aqueous solutions. The resulting material performed with a high adsorption capacity of 98.68 mg/g. Material characterization consisted of Raman spectroscopy (RS), X-ray diffraction (XRD), scanning electron microscope observations (SEM-EDX), Fourier transform infrared spectroscopy (FTIR) and point of zero charge (pHpzc). The adsorption study included pH study, effect of initial concentration, kinetics, ion effect, and reusability assessment. The RS, XRD, and FTIR results indicated that the main functional groups in the composite were related to hydroxyl and amino groups, and iron oxyhydroxide species of α-FeO(OH). The pHpzc was found to be 7.41. The best adsorption efficiency was set at pH 6. The equilibrium isotherms were better fitted with a non-linear Langmuir model, and the kinetics data were fitted with a pseudo-second order rate equation. The incorporation of iron into the chitosan matrix improved the Sb(III) uptake by 47.9%, compared with neat chitosan (CS). The material did not exhibit an impact in its performance in the presence of other ions, and it could be reused for up to three adsorption–desorption cycles.
Tuning Physical Crosslinks in Hybrid Hydrogels for Network Structure Analysis and Mechanical Reinforcement
Authors: Lv Xue , Liu Chuang , Shao Zhubao , Sun Shulin
Published: February 2019

Hydrogels with high mechanical strength are needed for a variety of industrial applications. Here, a series of hydrogels was prepared by introducing hybrid particles as hydrophobic association points to toughen the hydrogels. These toughened hydrogels were able to transfer an external mechanical force via the reorganization of the crosslinking networks. They exhibited an extraordinary mechanical performance, which was the result of the coordination between hydrophobic segments and hybrid particles. Herein, the connection between the dissipated energy of the inner distribution structure (on a small scale) and the mechanical properties (on a large scale) was conducted. Specifically, we inspected hydrogels of latex particles (LPs) with different chain lengths (C4, C12, C18) and studied their inner structural parameters, namely, the relationship between the density and molecular weight of crosslinking points to the mechanical strength and energy dissipation. Favorable traits of the hydrogels included compact internal structures that were basically free from defects and external structures with puncture resistance, high toughness, etc. Based on the experimental results that agreed with the theoretical results, this study provides a profound understanding of the internal structure of hydrogels, and it offers a new idea for the design of high-strength hybrid hydrogels.
Flocculation of a High-Turbidity Kaolin Suspension Using Hydrophobic Modified Quaternary Ammonium Salt Polyacrylamide
Authors: Ma Jiangya , Fu Xue , Xia Wei , Fu Kun , Liao Yi
Published: February 2019

In this work, a novel cationic polyacrylamide (PAMD) was synthesized by acrylamide (AM) diallyl dimethyl ammonium chloride (DMD) and dodecyl polyglucoside (DPL) under low-pressure ultraviolet (UV) initiation. The intrinsic viscosity and cationic degree of PAMD were optimized in copolymerization. The optimum synthesis conditions that affect polymerization were determined to be solid content 30%, DPL content 25%, DMD content 30%, illumination time 135 min, and pH 9. The flocculation performance of flocculant PAMD with a high cationic degree was investigated in the purification of high-turbidity water. The flocculation mechanism was correspondingly studied and summarized based on Fourier transform-infrared (FTIR) analysis. Finally, the results of an experimental simulation using the response surface method show that 98.9% supernatant transmittance was achieved under dosage 4 mg/L, fast stirring time 20 min, pH 7, and stirring speed 320 rpm.
Environmental Revolution in Contemporary Buddhism: The Interbeing of Individual and Collective Consciousness in Ecology
Authors: Lim Hui Ling
Published: February 2019

A spiritual awakening is necessary to address the global ecological crisis and to bring about an environmental revolution. The aim of this paper is to bring together various passages from Thich Nhat Hanh’s works that refer to a collective consciousness and environmental revolution, in order to gain some insight into what the view of contemporary Buddhism might have been on the idea of Buddhist environmentalism. This paper is divided into three main areas: the concept of interbeing, the view on the interdependent nature of individual and collective consciousness, and the various interdependent elements influencing the transformation of consciousness that could bring about an environmental revolution in ecology. In using the concept of interbeing coined by Thich Nhat Hanh, I argue that this understanding of the interconnected relationship of everything in the world will enhance the awareness of a global environmental movement for a better future, which is possible.
Hardwar: Spirit, Place, and Politics
Authors: Singh Vikash , Parashar Sangeeta
Published: February 2019

This article describes the narratives and projections that shaped the contested character of Hardwar and the river Ganges as symbols par excellence of the Hindus’ claim to India’s sacred geography over the last two hundred years. It deliberates on the tactics and practices through which Hardwar’s ancient and legendary status has been employed to assert Hindu identity and territorial claims vis-à-vis the colonial administrators, but also to exclude the country’s Muslim and Christian populace. The purifying, divine land of Hardwar enabled the nationalist imagination and struggle for a Hindu India, even as it was instituted as a site for the internal purification of Hinduism itself, to mirror its glorious past. The article describes the contests and claims, based on religion and class, as well as the performance of socio-economic and existential anxieties that the sacred quality of Hardwar and the river Ganges continues to authorize and enable in post-colonial India. For this, we draw particularly on the Kanwar Mela, an annual event in which millions of mostly poor young men carry water from the river Ganges on foot, and often over long distances. We deliberate on the significance of the sacred water, rituals, and the journey in reinforcing these pilgrims’ perceptions of the self, and their moral claims over the nation and its territory.
Development of a Novel SMA-Driven Compliant Rotary Actuator Based on a Double Helical Structure
Authors: Kittinanthapanya Rasheed , Sugahara Yusuke , Matsuura Daisuke , Takeda Yukio
Published: February 2019

This paper proposes a new shape memory alloy (SMA)-driven compliant rotary actuator that can perform both passive and self-actuated motions. This SMA actuator is suitable as a redundant actuation part in a parallel robot joint to assist with singularity postures where the robot might lose the ability to maintain the position and orientation of the end effector. The double helical compliant joint (DHCJ) was chosen as a candidate mechanism; it can act in soft compliance with linear characteristics and a wide range of motion. The experimental results validated that the proposed model can be used to simulate the DHCJ behavior. The use of this mechanism exhibits advantages such as one-axis rotational motion, linear behavior even for a compliant mechanism, stiffness in the other axes of motion, and compact size. SMA leaves (strips) were used as actuation parts, and a single SMA leaf was tested before combining with the double helical frame as an SMA actuator. The prototype was fabricated, and necessary parameters such as deflection angle, temperature, torque, and stress–strain were collected to define the model for a controller. This actuator is controlled by a feedforward controller and provides rotational motion for both forward and reverse sides with a maximal range of 40 degrees.