bluuebunny/crossref_metadata_2025 huggingface dataset:
Стабилизатор постоянного напряжения
Authors: Жмакин Н.Е.
Published: August 2023

Стабилизатором напряжения является прибор, который автоматически может поддерживать не изменяющееся напряжение или ток на нагрузке с назначенной степенью точности при изменении дестабилизирующих факторов. Данный прибор относится к электротехнике и используется в источниках второстепенного электропитания радиоэлектронной аппаратуры.
Интеграция телевидения и цифровых каналов для проведения рекламных кампаний
Authors: Манжосов Д.К
Published: August 2023

В научной статье рассматривается явление интеграции телевидения и цифровых каналов в рамках рекламной деятельности. В статье рассмотрено медиапотребление телевизионного контента в России, бюджеты крупнейших рекламодателей на российском рынке и роль телевизионного формата в бюджете, рассмотрено применение интеграции для выполнения маркетинговых задач, задач по продвижению, а также рассмотрена технология ―мультискрин‖ и пример ее реального использования.
TRABZON VİLAYETİ ÖRNEĞİNDE OSMANLI DEVLETİ’NDE MUZIR NEŞRİYATLA MÜCADELE
Authors: TAN Hakan
Published: August 2023

Basın ve yayın faaliyetlerinde gerçekleşen gelişim ve dönüşüm uygarlık tarihine pek çok açıdan katkı sağlamıştır. Özellikle matbaanın yaygınlaşmasının ardından kâğıda dökülen bilgi ve düşünceler çok sayıda insan tarafından kolaylıkla ulaşılabilir hale gelmiştir. Ancak bu durum iktidarları endişelendirmiştir. Devleti yönetenler, düşüncelerine ve menfaatlerine ters düşen yayınlara karşı bazı önlemler geliştirmişlerdir. Buna bağlı olarak yöneten sınıf tarafından onaylanmayan yayınlara karşı sansür uygulanması yaygınlaşmıştır. Sakıncalı görülen eserleri tespit etmek, kontrol altına almak ve yayılmasını önlemek için çeşitli kurumlar oluşturmuş, farklı uygulamalar ortaya konulmuştur. Bu çalışmada Osmanlı Devleti’nin muzır olarak nitelendirdiği yayınlara karşı vermiş olduğu mücadele Trabzon Vilayeti örneğinde ele alınmıştır. Muzır yayınlara karşı devletin bakış açısı, muzır neşriyatın hangi yollarla Osmanlı ülkesine sokulduğu ve bu kapsamda devlet tarafından alınan önlemler incelenmeye çalışılmıştır.
3- and 4-Arm Star Polymers (PEG3 and PEG4) via Metal-Free Azide-Alkyne Click Reaction
Authors: GÜNAY Ufuk Saim
Published: August 2023

Star polymers are known for their different structural and functional properties. Depending on their structure, they may display a wide range of characteristics. Star polymers can be synthesized using either a core-first or arm-first strategy. Numerous synthetic approaches can be used in both cases. In this work, 3- and 4-arm star polymers were prepared via the metal-free azide-alkyne click reaction. Trifunctional and tetrafunctional propiolate (acetylenecarboxylate) ester-containing cores were prepared and then subjected to a metal-free azide-alkyne reaction with azide end-functionalized PEG (PEG-N3) to yield A3 and A4-type star polymers, respectively. All the structures were characterized using 1H and 13C NMR spectroscopy and GPC.
Diseño, Arte, Tecnología y Ciencia: Escenarios de Convergencia Disciplinar
Authors: Acuña Pontigo Oscar Andrés
Published: August 2023

El presente escrito aborda una reflexión en relación con los diversos campos de conocimiento que convergen en un espacio creativo, a partir de los postulados de Rich Gold sobre las fronteras y vínculos, del diseño, arte, tecnología y ciencia.
Diseño paramétrico y producción en Laboratorio de Fabricación
Authors: Barreno Ávila Alex , Monar Naranjo Martin
Published: August 2023

La huella de carbono mide el impacto de cambio climático que tiene el uso de un bien o servicio.
El uso del formato PDF en el mercado del producto impreso y editorial en un contexto de crisis y transformación digital
Authors: Santamaría Aguirre Jorge
Published: August 2023

El uso de tecnologías de información y comunicación se ha normalizado entre la población, acción que contempla la transferencia de datos de forma virtual en diferentes casi todas las actividades humanas.
Encuentros de ilustración como motor del desarrollo académico, creativo y cultural
Authors: Mena Freire Julia
Published: August 2023

La academia constantemente precisa oxigenarse de prácticas creativas para complementar la formación de estudiantes, es el caso de la Facultad de Diseño y Arquitectura de la Universidad Técnica de Ambato en Ecuador
Estudio de las posturas corporales de los diseñadores de interiores y su influencia en la salud ocupacional
Authors: Estévez Vásconez Débora , Viteri Medina Galo Alejandro
Published: August 2023

En la actualidad se ha evidenciado según datos del IESS –Instituto Ecuatoriano de Seguridad Social
Múltiples miradas en, desde y para el diseño y los objetos
Authors: Matarrese Marina , Vilchis Esquive Luz del Carmen
Published: August 2023

A continuación expreso el sustento de las elecciones que he marcado con relación al resultado de la investigación en la producción editorial de Cuaderno Nº172, desde una perspectiva académica-científica valorativa
Arte, Comunicación y Política: Experiencias y expresiones desde Latinoamérica
Authors: Aguerre Natalia , Palacios Navarro Janneth Arley
Published: August 2023

Los siguientes (3) ítems: “Actualidad de la temática”, “Nivel Alcanzado”, “Diversidad de enfoques” y “Calidad” los califico con calidad de NOTABLE –incluso un trabajo expresa la MATRIZ DE DATOS samajaniana enseñada por la Dr. Roxana Ynoub en el Doctorado de Diseño de la UP
Investigación en Diseño. Memoria 2015-2020 Volumen 1
Authors: Echevarría Oscar
Published: August 2023

El material que se presenta para evaluación es un destacado insumo para favorecer la socialización y retroalimentación de las tareas de investigadores formados y en formación.
La Moda en su Laberinto
Authors: Echevarría Oscar
Published: August 2023

El tema resulta relevante a la investigación académica. Indaga acerca de la moda desde múltiples miradas multidisciplinares que la constituyen en un objeto de estudio tan complejo como pertinente de abordar en el universo de implicancias del diseño.
La Moda en su Laberinto. Parte IV
Authors: Doria Patricia
Published: August 2023

Nada más cambiante que la moda que se alimenta de la sociedad y sus variadas maneras de manifestarse, ella se nutre de forma transversal de muchas disciplinas, sucesos y fenómenos sociales.
Fake News y desinformación: desafíos para las democracias de América Latina y el Caribe
Authors: Mendoza Marina , Dagatti Mariano , López López Paulo Carlos
Published: August 2023

Os artigos do Cuaderno Nº 161 abordam com muita consistência o fenômeno mundial que cresce e se impõe como um dos maiores desafíos da sociedade contemporânea: as noticias falsas e seu impacto nas nos países e democracias latinoamericanas.
Derecho, Sostenibilidad y Diseño
Authors: Bello Knoll Susy , Polanco Juan Sebastián
Published: August 2023

De entrada habrá que destacar el trabajo continuado (por tercer año) lo cual permite consolidar la reflexión y los aportes derivados de la vinculación.
Diseño y Artesanía: Economía creativa y patrimonio para el desarrollo de comunidades
Authors: González Elicabe Ximena , Luna Felicitas , García López Ana
Published: August 2023

El Cuaderno Nº 171 tiene el acierto de otorgar el nivel simbólico que representa la artesanía en el devenir social de las culturas de América Latina y España.
La creatividad necesita un contexto creativo
Authors: Pasotti Laura
Published: August 2023

Este ensayo se configura a partir de la reflexión sobre mi práctica docente. Durante las clases, frente a futuros productores visuales, nace una pregunta
Efecto bioestimulante de una chalcona sintética sobre frijol guajiro (Vigna unguiculata L. Walp)
Authors: Valero Valero Nelson Osvaldo , Chima Martínez Kenia Adolfina , Gómez Gómez Javier Alexander
Published: August 2023

El frijol guajiro es un cultivo de subsistencia importante en zonas secas del caribe colombiano, allí, los tensores ambientales a menudo ocasionan estrés vegetal y limitan la producción agrícola. Los bioestimulantes vegetales mejoran el desempeño de las plantas bajo condiciones de estrés; las chalconas no se han estudiadas como bioestimulantes pero son moléculas multifuncionales que expresan bioactividad y están involucradas en la regulación del metabolismo vegetal, por lo anterior es conveniente estudiar sus propiedades como bioestimulantes en la agricultura. El objetivo del trabajo fue evaluar el efecto de la chalcona sintética 3-(4-nitrofenil)-1-(piridin-2-i)-prop-2-en-1-ona (CHSNPP) sobre el crecimiento temprano del frijol guajiro (Vigna unguiculata), bajo condiciones de cámara de crecimiento vegetal, para aportar evidencia sobre una posible aplicación como biestimulante. Se probaron soluciones de CHSNPP a concentraciones de 25, 50, 100 y 150 ppm, y se evaluaron dos formas de aplicación (por aspersión foliar- AF e inmersión - IM de plántulas en la solución). El tratamiento mediante IM  con 25 ppm ocasionó un incremento del 321 % en el área superficial de raíces, con 50 ppm hubo incremento del 78 % en el número de nódulos formados por la simbiosis con rizóbios nativos presentes en el suelo, además de incrementos del 111 % en biomasa y del 16 % en el índice de contenido de clorofila -ICC, finalmente con 150 ppm se incrementó el número de raíces hasta el 82 %; por su parte, el tratamiento mediante AF con 150 ppm ocasionó incrementos en  área foliar y biomasa  del 101 % y 137 %. Se concluye que las respuestas observadas en las plantas tratadas con CHSNPP son características de los mecanismos de acción de algunos bioestimulantes no microbianos, lo que permite sugerir un posible uso como bioestimulante en frijol guajiro.
Evaluación de microorganismos y sustratos obtenidos a partir de residuos orgánicos para la producción de celulasas
Authors: Sanchez Castelblanco Etna Milena , Heredia Martín Juan Pablo
Published: August 2023

La necesidad de reducir los costos de producción de las enzimas y su amplia utilización en diferentes sectores industriales, ha incrementado el interés en la valorización de residuos agroindustriales como sustratos para la obtención de estos bioproductos. Los residuos agrícolas son una fuente tanto de celulosa como de microorganismos productores de celulasas, por lo que este estudio tuvo como propósito la selección de bacterias celulolíticas aisladas previamente de residuos generados en plazas de mercado y la evaluación de medios formulados a partir de estos. 11 cepas bacterianas fueron cultivadas en caldo Mandels durante 72 horas, evaluando su actividad celulolítica a 30 y 50 ºC. Para la formulación de medios de cultivo se determinó el contenido de celulosa, nitrógeno y carbono orgánico total de los ameros de mazorca y vainas de leguminosas recolectados en una plaza de mercado. Se elaboraron tres medios de cultivo utilizando los residuos como fuente de celulosa y suplementándolos con peptona, sulfato de amonio y urea como fuente de nitrógeno. El medio A se formuló con residuos troceados y deshidratados, en el medio B estos tuvieron el mismo tratamiento adicionando un paso de licuado y para el medio C se utilizaron residuos licuados sin deshidratar. De las 5 cepas celulolíticas seleccionadas, C6M2 fue cultivada a 37 ºC en los tres medios y la actividad enzimática fue monitoreada durante las 96 horas de fermentación. En los medios A y B se evidenció la producción de celulasas, siendo A el que presentó una mayor actividad (19,82 ± 3,0 U/mL), mientras que en el medio C no se evidenció actividad celulolítica. En conclusión, la cepa bacteriana seleccionada C6M2 es capaz de producir celulasas en medios de cultivo formulados con ameros de mazorca y vainas de leguminosas troceados y deshidratados.
Renal Tubular Acidosis: Recognition and Treatment Strategies
Authors: Gomez Maria Isabel
Published: August 2023

Renal tubular acidosis (RTA) is a group of kidney disorders characterized by impaired renal acidification, leading to disturbances in acid-base balance. This review article provides a comprehensive overview of RTA, including its epidemiology, pathophysiology, clinical presentation, and diagnosis. Three main types of RTA are discussed: distal RTA (Type 1), proximal RTA (Type 2), and hyperkalemic RTA (Type 4). Each type’s underlying causes and mechanisms are explored, highlighting the importance of accurate diagnosis for appropriate management. Diagnostic approaches involving clinical evaluation, laboratory tests, and specialized renal function studies are described in detail. The treatment strategies for each type of RTA are outlined, emphasizing the importance of correcting the acid-base imbalance and managing associated electrolyte abnormalities. Lifestyle modifications and pharmacological interventions are discussed, including alkali supplementation and potassium regulation. Finally, the need for further research and prospective studies to enhance our understanding of RTA and improve therapeutic interventions is emphasized. Advancements in diagnosis and treatment approaches have the potential to maximize patient outcomes and improve the quality of life for individuals affected by RTA.
Effectiveness of Father Education Programs ın Improving Personal Care Skills ın Individuals with Autism Spectrum Disorder
Authors: GÜNLÜ Yasin , CAKMAK Salih
Published: August 2023

This study investigated the effectiveness of the Father Education Program in implementing the steps of teaching personal care skills to participating fathers, examined the level of performance in personal care skills taught by fathers to individuals with autism spectrum disorder (ASD), analyzed the impact on the sustainability of these skills, and determined the views of the parents of individuals with ASD regarding the research process and effectiveness. There were two dependent variables. The first dependent variable was "the level of implementation of the steps of teaching personal care skills by the fathers participating in the research", and the second dependent variable is "the level of children with ASD performing the personal care skills taught to them by their fathers and the level of maintaining the skills they have performed". The independent variable was the “Father Education Program”. Therefore, the study was carried out in two experimental processes. While three fathers with a child with ASD participated in the first experiment, their children participated in the second experiment. The first experimental period of the study was designed according to the multiple probe design across subjects whilst the second experimental period was designed according to multiple probe design across skills. The developed program was implemented to fathers in five sessions, and after fathers met the criteria, they taught their children personal care skills such as "shaving a beard using a razor, cleaning underarms using a bath razor, and cleaning the genital area using depilatory cream". Study results revealed that the father education program was effective in terms of participant fathers’ implementing of the steps of teaching personal care skills to their children. Additionally, individuals with ASD were able to perform and maintain the personal care skills taught to them by their fathers. Lastly, the parents of participant individuals with ASD had positive views on the research process and its effectiveness.
Hayat Bilgisi Öğretiminde Orman Okulunun Rolü Üzerine Sınıf Öğretmenlerinin Görüşleri
Authors: AYDIN Yıldıray , AYKIRI Kudret
Published: August 2023

Orman okulu, ormanda ya da diğer doğal alanlarda belirli prensiplere uygun olarak doğayla daha çok teması ya da dost olmayı temel alan bir pedagojidir. Bu pedagojinin ilgili literatür bağlamında hayat bilgisi öğretimi ile ilişkili olduğu görülmektedir. Bu ilişkinin önemli bir paydaş olan öğretmenlerin görüşleri üzerinden incelenmesi anlamlıdır. Bu bağlamda bu araştırmanın amacı hayat bilgisi öğretiminde orman okulunun rolü üzerine öğretmenlerin görüşlerinin incelenmesidir. Araştırmada nitel araştırma yöntemlerinden durum çalışması yöntemi kullanıldı. Katılımcılar amaçlı örnekleme yöntemine göre belirlendi. Araştırmada yarı yapılandırılmış görüşme formu ve ilgili dokümanlar (etkinlik planı ve fotoğraflar) ile veri toplandı. Veriler betimsel analiz yöntemi ile analiz edildi. Araştırmacının rolü ve etik durumdan bahsedildi. Geçerlilik ve güvenirlilik sağlandı. Araştırmanın sonuçları şu şekildedir: Hayat bilgisi öğretiminde orman okulu deneyimi anlamlıdır. Bu deneyim için en uygun ünite doğada hayat ünitesidir. Bu deneyimden hem öğretmenler hem öğrenciler kazanım elde etmektedirler. Bu deneyim öncesinde gerekli hazırlıklar yapılır ve önlemler alınır ise problem yaşanma ihtimali azdır. Deneyimlerde daha riskli oyunlara ve görevlere yer verilmelidir. Doğa ve fen okulu kavramsallaştırılmasında doğa kavramı uygundur ama fen kavramı değiştirilebilir.
Impact of controlled pharmacist communication-based interventions on patient adherence to antibiotics: a protocol of a systematic review
Authors: Pires Carla
Published: August 2023

Community and hospital pharmacists are prepared to educate or involve patients in specific interventions/programs aiming at improving antibiotic adherence. Importantly, improved antibiotic adherence is associated with the reduction of the risk of antibiotic resistance. Pharmacist communication-based interventions to improve patients’ antibiotic adherence are diverse, such as interviews, education/counselling, the provision of written information or workshops, knowledge assessment, among others. Thus, a protocol of a systematic review to evaluate the impact of pharmacist communication-based interventions on patients’ adherence to antibiotics is presented. The PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses for systematic review protocols) was applied. The detailed project of the present systematic review is already published in Registry Services – Open Science Framework (OSF). The confirmation of a positive impact of communication-based interventions on patients’ antibiotic adherence in community or hospital pharmacies is expected.
Addressing the digital divide: who is being left behind in the evaluation of e-Health interventions to improve medication adherence?
Authors: Gregório João , Maricoto Tiago , Moreira Paulo A.S. , Roque Fátima , Correia-de-Sousa Jaime , Herdeiro Maria Teresa , Almeida Isabel F , Tsiligi Ioanna , Agh Tamas , Jácome Cristina
Published: August 2023

The implementation of e-Health initiatives aimed at improving medication adherence has shown limited success. This may be attributed to inadequate participant selection in evaluation studies. The objective of this evidence-based commentary is to examine the inclusion criteria of participants in e-Health interventions for medication adherence. In May 2021, we identified two systematic reviews, encompassing a total of 44 randomized controlled trials (RCTs) evaluating e-Health interventions for medication adherence. These interventions were aimed to diabetes (n=10), immunosuppressive therapy (n=6), and cardiovascular diseases (n=29). Participants in interventions utilizing digital apps had a lower mean age compared to those using telephones (53.9 ± 7.5 years vs. 63.4 ± 6.3 years). Most papers (91.0%) did not report participants' level of digital literacy, and educational background was only mentioned in 57.8% of the studies. Exclusion criteria associated with age, education, health conditions, were identified in the assessment of e-Health interventions, while digital literacy was seldom assessed. It is recommended incorporating the assessment and reporting of digital literacy into participant selection procedures in RCTs to address the digital divide and obtain more accurate information regarding the efficacy of e-Health interventions. Keywords: Medication adherence, e-Health evaluation, digital divide, health inequities, digital health
Insights on liver transplantation and multimodal treatment for intrahepatic cholangiocarcinoma
Authors: Logarajah Shankar , Nida John , Simoneau Eve , Yohanathan Lavanya
Published: August 2023

The treatment of intrahepatic cholangiocarcinoma (iCCA) has traditionally been limited to surgical resection or systemic therapy. The role of liver transplantation in the management of iCCA is a topic currently being explored. This paper serves as a review to highlight past, present, and future work being done in regard to liver transplantation for iCCA. Strict protocols with specific selection criteria have shown promising results. Neoadjuvant therapy, locoregional therapy, and immunotherapy are some of the tools that may aid in bridging selected patients with iCCA to liver transplantation. There are currently three ongoing trials designed to further evaluate the efficacy of liver transplantation for iCCA. As criteria continue to be refined and evidence accumulates, liver transplantation may become a suitable option as a curative treatment strategy for highly selected patients with unresectable intraoperative cholangiocarcinoma.
Perspective of tumor heterogeneity for treatments of intrahepatic cholangiocarcinoma with intrahepatic lithiasis
Authors: Hou Wenjie , Tu Yifan , Zheng Minghua , Zeng Qiqiang
Published: August 2023

The heterogeneity of tumors results in significantly distinct biological characteristics of intrahepatic cholangiocarcinoma (ICC) caused by different etiologies. Among them, ICC caused by intrahepatic lithiasis (IHL-ICC) presents challenges in early detection, tumor staging, and surgical treatment, and has the poorest prognosis among all etiologies of ICC patients. Thus, it is essential to focus on early assessment of the possibility of developing ICC, prompt intervention of intrahepatic lithiasis, anatomical resection of hepatic parenchyma corresponding to the branch of the intrahepatic bile duct undergoing cancerous transformation, and enhanced postoperative follow-up of hepatolithiasis and ICC for IHL-ICC patients. These interventions are crucial to improve the clinical outcomes and overall survival of IHL-ICC patients.
QTL Epistasis Plays a Role of Homeostasis on Heading Date in Rice
Authors: Huang Lilong , Tang Jichun , Zhu Bihuang , Chen Guodong , Chen Leyi , Bu Suhong , Zhu Haitao , Liu Zupei , Li Zhan , Meng Lijun , Liu Guifu , Wang Shaokui
Published: August 2023

To avoid the endless accumulation of QTL effects during pyramiding breeding, QTL epistasis plays a role of homeostasis. Four single-segment substitution lines with heading date QTLs were utilized to construct pyramiding materials with dual QTLs and triple QTLs, allowing for the estimation of QTL epistatic effects on heading date in rice. The epistatic components of dual QTL and triple QTL interactions were analyzed using data from three seasons of two years. All four QTLs can be considered as dominant loci, demonstrating superdominance. 75% of dual QTL interactions and 81.25% of triple QTL interactions obtained statistically significant results, reaffirming the prevalence of epistasis. Interactions of four QTLs with three positive effects and one negative effect generated 62.5% negative dual QTL epistatic effects and 57.7% positive triple QTL epistatic effects, forming the balance relationship “positive-negative-positive”. In fact, QTL effects were consistently partially neutralized by mixed QTL epistatic effects so as to control the infinite accumulation of QTL effects. QTL epistasis plays a role of homeostasis on heading date in rice. However, there were two exceptions. The directions of OsMADS50 and Hd3a-2 effects were consistently aligned with those of their mixed epistases, suggesting that the QTL or gene could be employed in pyramiding breeding with different objectives. This study elucidated the mechanism of epistatic interactions among four QTLs and provided valuable genetic resources for improving heading date in rice.
Study of the Ecological and Reclamation Condition of Abandoned Lands and their Development for Sustainable Development Goals
Authors: Laiskhanov Shakhislam , Smanov Zhassulan , Kaimuldinova Kulyash , Aliaskarov Duman , Myrzaly Nazira
Published: August 2023

To provide the population with food, it is very important to re-cultivate "abandoned lands" that have been retired from agricultural use. Conversion of arable land into agricultural abandoned lands in the south of Kazakhstan is, first of all, was primarily associated with salinity. For the purposes of sustainable development, there is a need to develop proposals for re-mastering by studying their current state, reviewing world studies on the reclamation of salt-affected soils. Therefore, this study was devoted to the study of the current environmental and reclamation conditions of the abandoned lands of Otyrar district in the south Kazakhstan, as well as discussion and recommendations on their development. In the course of the research, the historical method is used in the study of the emergence and formation of abandoned lands, the method of geographical analysis during the territorial analysis of the research object, the statistical and comparison methods in showing the complexity and intensity of the problems, the cartographic, geo-informational and field research (reconnaissance) methods in the study of the condition of the abandoned lands in the research object and methods of grouping and analysis were used in the work with scientific data on the topic of research. By deciphering space images with the help of geoinformation technologies, it was revealed that the area of abandoned lands in the research object is 13688.9 ha, including the area of non-saline soils – 83.9 ha, weakly saline soils – 984.4 ha, medium saline soils – 2398.3 ha, highly saline soils – 10222,1 ha. A review of the methods and technologies proposed by scientists for the development and melioration of salt-affected lands was made. Taking into account the ecological and reclamation state of the object of research along with the material and technical capabilities of farms, 2 methods of developing abandoned lands (organic and agro-innovative) in the research object are proposed and the need for their use in case of soil salinization has been scientifically justified.
How Patient Safety Culture Influences Adverse Event Reporting and Use of the Incident Reporting Tool: A Systematic Review
Authors: Cerrone Valentina , Aliberti Silvana Mirella , Prendin Angela , Ilardi Bernadette , Funk Richard H.W. , Andretta Vincenzo , Capunzo Mario
Published: August 2023

Patient safety is a top priority for all healthcare systems globally. Promoting the adoption of policies for reporting and learning from errors is an important strategy for improving care safety. Therefore, the aim of our study was to detect how much patient safety culture influences the reporting of adverse events and the use of the incident reporting tool. The study protocol was developed according to PRISMA guidelines. Articles were searched electronically in PubMed/MEDLINE, the COCHRANE library, and Google Scholar by two independent reviewers, and those that met the eligibility criteria were included. Synthesis of qualitative data from included studies was performed by graphical descriptive statistical analysis. The results of the systematic review showed that health care organizations' increasing focus on staff development of a safety culture has led to a significant increase in incident reporting rates over the years. Moreover, in situations where safety culture is placed at the top of the nations, there is a higher frequency of incident reporting. An efficient incident reporting system should be an essential foundation for healthcare organizations, as it allows them to collect experiences and data and provide feedback to healthcare providers and staff involved in care.
Socıally Orıented Approaches in Cıtıes—Hasanpasa Gasworks and Gasworks Envıronmental Volunteers
Authors: Yuksel Sen , Savas Demir Hatice
Published: August 2023

The participation of the public in the decision, use and maintenance of the heritage structures in the cities brings positive results to that city. Istanbul Kadikoy-Hasanpasa Gasworks was closed in 1993 and lost its function, and in 2021, it was reopened for use as a culture and art center. In the transformation decisions of the gasworks, the Gasworks Environmental Volunteers, consisting of the people of the environment, have played an active role for 27 years and continue to play a role after the transformation. This study examines the impact and efforts of Gasworks Environmental Volunteers before and after the transformation and describes a collective struggle in the participatory management of heritage. As a result of face-to-face interviews, observations, and literature research conducted with a qualitative research method, the effects of non-governmental organizations on heritage sites were examined. The data obtained will increase the awareness of the society on the heritage areas and contribute to the fact that the society will be a factor in the transformation decisions by protecting the heritage.
Cynical Treatise – Queer Theory and Geography
Authors: Juraev Zuhriddin , Ahn Young-Jin
Published: August 2023

This essay critically discusses the integration of queer theory into human geography while emphasizing its ties to the principles of traditional geography. The need for a separate sub-discipline called queer geography is questioned. At the same time, legitimate concerns about possible departures from the fundamental goals of geography and the risks of anachronistic interpretations in applying modern concepts to historical landscapes are acknowledged. In this discourse, we strongly advocate for values such as freedom of speech, freedom of expression, and international human rights. It is important to emphasize that it is not the intent of this essay to denigrate campaigns for feminism or equality or to disparage the scholarship that emerges from the application of queer theory. On the contrary, we recognize the emergence of gender theories out of a need to advance social justice approaches. We believe that traditional human geography, itself, is capable of comprehensively examining space, time, and the complexity of human experience and offering workable solutions within its established framework. We therefore believe that the inclusion of queer theory can be harmoniously integrated into the contours of human geography, eliminating the need for a separate sub-discipline while preserving the integrity and purpose of the discipline.
Development of Hybrid Membrane Systems for Highly Mineralized Waste Utilization of Power Industry
Authors: Iliev Iliya Krastev , Chichirov Andrey Alexandrovich , Filimonova Antonina Andreevna , Chichirova Natalia Dmitrievna , Pechenkin Alexander Vadimovich , Beloev Ivan Hristov
Published: August 2023

Hybrid reverse osmosis electrodialysis systems make it possible to obtain solutions with a higher concentration of components compared to single electrodialysis treatment, i.e. more efficient separation of brine and pure water. The article proposes experimental and pilot-industrial studies of a hybrid membrane system operation using industrial wastewater for the disposal of liquid waste from an ion-exchange chemical-desalting water treatment plant of a thermal power plant, followed by a calculation of economic efficiency and an analysis of the environmental feasibility of their use. The developed technological scheme offers separate processing of acidic and alkaline waste regeneration solutions using calcium carbonate reagent and desalination on baromembrane and electromembrane units to obtain clean water and dry residue. The hybrid system includes a booster filter press and an evaporator. The hybrid system makes it possible to provide a thermal power plant with a "zero discharge" with a minimum consumption of reagents and electricity, as well as return all water from wastewater to the power plant cycle.
Entrepreneurship Creates Sustainable Progress
Authors: Holcombe Randall G.
Published: August 2023

Sustainability means that the current use of resources does not compromise the well-being of future generations. Ever since Malthus (1798) forecast that population tends to grow faster than the growth of resources to support the population, people have claimed that current resource use is unsustainable, so future generations will be materially worse off than those in the present, yet for more than two centuries this has not been the case. The reason is that markets, and market prices, act to conserve scarce resources, and in market economies, entrepreneurs have an incentive to discover more efficient ways to use resources. The claim that twenty-first century market economies are not sustainable is not supported by the evidence. This paper explains why entrepreneurship in market economies produces sustainable economic progress.
Molecular Cloning and Gene Expression of Type I Suppressor of Cytokine Signaling 6 and 7 (SOCS6 and SOCS7) in White Leg Shrimps (Litopenaeus vannamei)
Authors: Gunasekara CWR , Madhuranga WSP , Lee Jiye , Kim Chan-Hee
Published: August 2023

Suppressors of cytokine signaling (SOCS) genes are essential negative regulators that modulate cytokine signaling and play key roles in numerous biological processes, including immune responses. In this study, we cloned the complementary DNA (cDNA) sequences of two SOCS genes, designated as LvSOCS6 and LvSOCS7, from the white-leg shrimp, Litopenaeus vannamei. LvSOCS6 encoded a polypeptide of 463 amino acids (aa), spanning 1,392 base pairs (bp), while LvSOCS7 encodes a significantly larger polypeptide of 955 aa, encompassing 2,868 bp. Both LvSOCS proteins exhibited conserved domains associated with SOCS, including a centralized Src homology 2 (SH2) domain and a C-terminal SOCS box. Phylogenetic analysis revealed that the deduced aa sequences of LvSOCS6 and LvSOCS7 cluster within the invertebrate type I SOCS family, indicating their evolutionary relatedness. Tissue distribution analysis demonstrated ubiquitous expression of both LvSOCS genes across all examined tissues, with LvSOCS6 showing heightened expression in the gills and LvSOCS7 exhibiting a remarkable preference for the gills and stomach. Notably, mRNA expression patterns of LvSOCS genes following LPS and poly (I:C) stimulations exhibit significant upregulations, while PGN stimulation yields incongruous results across the experimented tissues. Interestingly, concurrent with the diminished expression of LvSOCS6 and LvSOCS7, there is a significant elevation in mRNA expression levels of LvSTAT, a vital component of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. These findings shed light on the potential involvement of the newly discovered type I SOCS genes in regulating the JAK/STAT pathway and assuming pivotal roles in orchestrating the innate immune responses in L. vannamei defense mechanisms.
Involvement of the Soluble Guanylate Cyclase, Nitric Oxide Synthase and Cytokines Pathway in the Anti-inflammatory Profile of N-acylhydrazone Derivatives (JR19)
Authors: Da Silva Pablo Rayff , Apolinário Nadjaele de Melo , Da Silva Simone Ângela Soares , Araruna Maria Elaine Cristina , Costa Thássia Borges , Silva Yvnni M. S. de Medeiros e , Da Silva Teresinha Gonçalves , Dos Santos Vanda Lucia Lucia , De Moura Ricardo Olímpio
Published: August 2023

The N-acylhydrazone function has been reported as a pharmacophore group of molecules with diverse pharmacological activities, including anti-inflammatory effects. Thus, this study evaluated the anti-inflammatory potential of the compound N'-(3-(1H-indol-3-yl)benzylidene)-2-cyanoacetohydrazide (JR19) in vivo. The study started with the carrageenan-induced peritonitis model, followed by an investigation of leukocyte migration using the subcutaneous air pouch test and an assessment of the antinociceptive profile using formalin-induced pain. To find out the likely mechanism of action, a preliminary molecular docking study was performed focusing on the crystallographic structures of NFκB, iNOS, and sGCs. The computational study revealed satisfactory interaction energies with the selected targets, and the same peritonitis model was used to validate the involvement of the nitric oxide pathway and cytokine expression in the peritoneal exudate of mice pretreated with L-NAME or methylene blue. In the peritonitis assay, JR19 (10 and 20 mg/kg) reduced leukocyte migration by 59% and 52%, respectively, compared to the control group, with the 10 mg/kg dose used in subsequent assays. In the subcutaneous air pouch assay, the reduction in cell migration was 66%, and the response to intraplantar formalin was reduced by 39%, particularly during the inflammatory phase, suggesting that the compound lacks central analgesic activity. In addition, a reversal of the anti-inflammatory effect was observed in mice pretreated with L-NAME or methylene blue, indicating the involvement of iNOS and sGC in the anti-inflammatory response of JR19. The compound effectively and significantly decreased the levels of IL-6, TNF-α, IL-17, and IFN-γ, and this effect was reversed in animals pretreated with L-NAME, supporting a NO-dependent anti-inflammatory effect. In contrast, pretreatment with methylene blue only reversed the reduction in TNF-α levels. Therefore, these results demonstrate the pharmacological potential of the novel N-acylhydrazone derivative, which acts through the nitric oxide pathway and cytokine signaling, making it a strong candidate as an anti-inflammatory and immunomodulatory agent.
Vertical structure of the West Spitsbergen Current and its relationship to the altimetry-derived surface geostrophic currents.
Authors: Bulczak Anna Izabela Izabela
Published: August 2023

The altimeter-derived ocean currents have been sparsely evaluated against in situ measurements in the Arctic, particularly for extended time periods. This study uses the extensive mooring array situated in the Fram Strait, representing one of the longest ocean current records, to investigate the relationship between in situ and satellite-derived currents in the region. The primary objective of this research is to analyze the vertical structure of the West Spitsbergen Current (WSC), its spatio-temporal coherence, and its association with surface geostrophic currents during the period of 1997-2012. To assess the vertical structure of the WSC, we utilized the Empirical Orthogonal Functions (EOF) and cross-correlation analysis between neighboring moorings. Remarkably, both velocity components exhibited robust vertical coherence, particularly within the waters of the North Atlantic Inflow, at depths exceeding 800 m. These findings underscore the potential for surface measurements to effectively complement data gaps and facilitate the reconstruction of deeper currents with a monthly temporal resolution. Notably, the surface measurements explain approximately 67% of the variance in the top 800 m of the water column.This comprehensive investigation advances our understanding of the West Spitsbergen Current and its vertical characteristics in the Arctic. Moreover, our findings highlight the valuable synergy between in situ and satellite-derived data, providing critical insights for future ocean current studies in this ecologically sensitive region.
Why an Antioxidant Complex Twendee X® Prevent Dementia?
Authors: You Fukka , Harakawa Yoshiaki , Yoshikawa Toshikazu , Inufusa Haruhiko
Published: August 2023

Alzheimer's disease (AD) is a complex disease involving multiple factors such as amyloid plaque formation, mitochondrial dysfunction, telomere length, and oxidative stress. As the disease began 20 years before the onset of clinical symptoms, treatment of AD after its onset is likely to be too late to have a significant effect. Therefore, prevention from an early stage is important. Twendee X®︎ (TwX, Oxicut®︎) is an antioxidant supplement consisting of eight ingredients. TwX has been proven to prevent dementia in patients with mild cognitive impairment (MCI) in a multicenter, randomized, double-blind, placebo-controlled, prospective intervention trial. To elucidate the mechanisms of TwX on brain and cellular function, TwX was administered in in vitro experiments and in a C57BL/6 old wild-type, and spontaneous hyperglycemia model with accelerated cognitive decline, and its effects on diabetes, brain autophagy, neurogenesis, and telomere length were evaluated in comparison with those of the non-treated groups. TwX protected mitochondria from oxidative stress with higher antioxidant capacity than a single antioxidant. TwX not only lowered blood glucose levels, but also suppressed reduction of brain neurogenesis and loss of autophagy. Telomeres in aged mice were significantly longer than those in non-TwX-treated mice. Development of dementia is based on many factors of brain function. TwX was suggested to prevent dementia not only by its antioxidant effects, but also by its effects on diabetes, brain neurogenesis, telomere deficiency, and energy production.
Efficacy of Kan Jang® in Patients with Mild COVID-19: a Randomized, Quadruple-Blind, Placebo-Controlled Trial
Authors: Ratiani Levan , Pachkoria Elene , Mamageishvili Nato , Shengelia Ramaz , Hovhannisyan Areg , Panossian Alexander
Published: August 2023

Background and aim. The study aimed to assess the efficacy of the treatment of Kan Jang®, a fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and Eleutherococcus senticosus (Rupr. & Maxim.) Maxim in patients with mild symptoms of COVID-19. Methods. One hundred forty patients received six capsules of Kan Jang® (n = 68, daily dose of andrographolides – 90 mg) or placebo (n=72) and supportive treatment (paracetamol) for 14 consecutive days in a randomized, quadruple-blinded, placebo-controlled, two-parallel-group design. The efficacy outcomes were the rate of cases turning to severe, the detection rate of SARS-CoV-2 virus over the time of treatment, the duration and the severity of symptoms (sore throat, runny nose, cough, headache, fatigue, loss of smell, taste, pain in muscles) in the acute phase of the disease. Other efficacy measures included improving cognitive and physical performance, quality of life, and the levels of inflammatory blood markers - IL-6, c-reactive protein, and D-dimer. Results. Kan Jang® significantly (p < 0.05) reduced the rate of cases turning to severe (5.36%) compared to placebo (17.86%) and decreased the detection rate of SARS-CoV-2 virus over the time of treatment. The statistical difference in the rates of patients with clinical deterioration in the Kan Jang treatment and placebo control groups was significant (p = 0.0176) both in 112 patients included per protocol (IPP) analysis and in 140 patients included per intention to treat (ITT) analysis (p = 0.0236); the absolute risk reduction of cases by Kan Jang treatment was 12.5%, and the number Needed to Treat by Kan Jang was 8. The patient's recovery time (Number of sick days at the home/clinic) was shorter in the Kan Jang group compared with the placebo group. The rate of resolution of inflammatory symptoms in the Kan Jang® group was significantly higher compared with the placebo group, and relief of the severity of cough, sore throat/pain, runny nose, and muscle soreness. Kan Jang® significantly decreased the Wisconsin Upper Respiratory Symptoms scores compared to placebo in the sample size of 140 patients. However, the relief of fatigue and headache and the decrease of IL-6 in the blood was observed only in a subset of the 86 patients infected during the second three waves of the pandemic. Kan Jang® significantly increased physical activity and workout; however, it did not affect cognitive functions (attention and memory), Quality of life Score, inflammatory markers D-dimer, and c-reactive protein compared with the placebo group. Conclusions. Overall, the results of this study suggest that Kan Jang® is effective in treating mild and moderate COVID-19 irrespective of SARS-Cov-2 variants infection.
Effect of Exogenous Application of Different Concentrations of Indole-3-Acetic Acid as a Biostimulant on Onion (Allium cepa) Cultivation
Authors: Solano Roberto Carlos , Artola Adriana , Barrena Raquel , Ballardo Cindy , Sánchez Antoni
Published: August 2023

Indole-3-acetic acid (IAA) is a key vegetative hormone that plays crucial roles in plant growth and development. In this study, the effect of the exogenous application of IAA as a biostimulant in the cultivation of onions (Allium cepa) was investigated. Different IAA concentrations were evaluated to determine their effects on onion growth and chemical parameters. Various physical and chemical parameters such as total fresh weight, plant height, chlorophyll content, nitrates, total phenols, and antioxidant capacity (DPPH) were analyzed. The results revealed that exogenous application of IAA had a significant impact on onion growth and quality. Specifically, it was found that certain concentrations of IAA fostered a greater fresh weight of the bulb, an increase in the levels of phenolic compounds and a greater DPPH. However, the onion response to IAA was dependent on the concentration. In conclusion, the present study provides evidence that the exogenous application of IAA as a biostimulant can improve onion growth and quality. These results are relevant for the development of sustainable agricultural practices and could be oriented towards crop improvement.
Evaluation of potential predictive biomarkers for defining brain radiotherapy efficacy in NSCLC patients with brain me-tastases: A case report and review of literature
Authors: Luciano Angelo , Liguori Luigi , Polcaro Giovanna , Sabbatino Francesco , Pepe Stefano
Published: August 2023

Non-small-cell lung cancer (NSCLC) is the second most common cancer worldwide, resulting in 1.8 million deaths/year. Most of the patients are diagnosed with a metastatic disease. Central Nervous System is one of the major metastatic sites. Brain metastases are associated with severe neurological symptoms, shorter survival and worst clinical outcomes. Brain radiotherapy and systemic oncological therapies are currently used for controlling both cancer progression and neurological symptoms. Brain radiotherapy includes stereotactic brain ablative radiotherapy (SBRT) or whole brain radiotherapy (WBRT). SBRT is applied for single or multiple (≤ 4) small lesions (< 3 cm), while WBRT represents the best treatment choice in case of multiple and large brain metastases. In both cases radiotherapy application can represent an overtreatment causing severe toxicities without achieving a significant clinical benefit. So far, some scores have been proposed to define the potential clinical benefits derived from brain radiotherapy. However, most of them are not well validated into clinical practice. In this article, by presenting a clinical case of a patient with advanced NSCLC carrying a BRAFV600E mutation and brain metastases, we review the variables as well as the potential applicable scores to be considered in order to predict clinical outcomes and benefits from brain radiotherapy in patients with NSCLC and brain metastases.
Pathophysiology of Virus Infections: The Protein-Homeostasis-System Hypothesis
Authors: Kang Hyun-Mi , Lee Kyung-Yil
Published: August 2023

The etiological agent of various viral diseases has been identified, and clinical characteristics and complications of each disease are well known. In general, a viral disease appears as acute systemic inflammatory disease, but after acute infection, some patients remain asymptomatic carriers or suffer chronic viral diseases, suggesting that the phenomena are unavoidable processes for viruses’ coexistence with their hosts as virome in microbiota of human species. Although each viral disease has been described as having different pathophysiology, the host's control systems, including immune systems, against the insults from any viral infections, have the same components in previously healthy hosts. Therefore, considering the characteristics of the life cycle of viruses being dependent on the host cell and the same immune components of the host, it is reasonable assumption that there is a common immune mechanism to respond to the insults from all viral diseases. The authors discuss on the characteristics of virus infection and unresolved issues in viral diseases and propose a rationale of early immune modulators for acute insults from viral diseases based on our clinical experiences and the protein-homeostasis-system hypothesis.