bluuebunny/crossref_metadata_2025 huggingface dataset:
Voltammetric Determination of Ferulic Acid on Carbon
Mesoporous Modified Glassy Carbon Electrode
Authors: Srivastava Ayushi , Shrivastava Sadhana
Published: February 2023

The electrochemical determination of ferulic acid was carried out with highly sensitive and rapid
square wave voltammetry (SWV) and cyclic voltammetry (CV) techniques by using bare glassy carbon
electrode and carbon mesoporous fabricated glassy carbon electrode (CMP/GCE). The oxidation
kinetics of ferulic acid was studied after the experimental conditions were optimized. A voltammetric
study of ferulic acid at the CMP/GCE electrode exhibited a well-defined anodic peak in phosphate
buffer at pH 2.2. The square wave oxidation peak current of ferulic acid was linearly increased over
the concentration range from 1 to 7 μg mL-1. The LOD and LOQ for ferulic acid were calculated as
0.36 and 1.10 μg mL-1, respectively. The analytical application of the developed sensor was evaluated
by a real sample analysis of ferulic acid in sweet corn.
An Overview of Physical Properties of Fruit Wastes Mediated Green
Synthesized Transition Metal Oxide Nanoparticles and Its Applications
Authors: Singh Ajay , Chaudhary Mahima
Published: February 2023

Different fruit peel wastes have a scope of utilizing in green synthesis of various transition metal
oxide nanoparticles (TrMONPs). This articles reveals about the physical properties and their applications
of green synthesized TrMONPs mediated through fruit peel wastes. Various transition metal
nanoparticles like Ag, Au, Ti, Zn, Cu, Fe, Ni, Pd have been synthesized successfully by peels of
mango, banana, pomegranate, apple and other citrus fruits. The SEM analysis revealed that the most
of the synthesized silver nanoparticles were spherical in the range of 10 to 15 nm and have wide
applications as antimicrobial agents, sensors, conducting materials, etc. ZnONPs were synthesized by
mediated through most of the fruit peels found in range of 20 to 50 nm (spherical shape) with applications
as photocatalyst. TiO2 nano-particles synthesized were spherical and hexagonal with high optical
properties as well as UV absorbent nature targeting applications in cosmetics. The other metals viz.
Au Cu, Ni, Pd nanoparticles synthesized mediated citrus fruit peels showed crystallinity. SEM analysis
confirmed the surface morphology while XRD confirmed the high crystallinity of the metals
nanoparticles. FT-IR have been widely used by the researchers for confirmation of new bond formation
in nanoparticles. It is also evident that scandium and vanadium from 3d-series and other 4d-transition
metals are less approachable and not used in fruit peel waste mediated green synthesis. The nanoparticles
of Ni, Pd, Zr, Cu, Fe and other metals (TrOMNPs) have also been found with optimum surface area
and size less than 10 nm for adsorption due to which these have application as catalyst in many
organic synthesis. Other applications are biochar, bio-sorbent, carbon dots, edible films, heavy metals
absorption, waste water treatment and in medicinal fields. Furthermore, approaches that can aided
into development of these nanoparticles is the perspective towards incorporating green methods like
laser ablation, sol-gel process, microwave heating, chemical vapour deposition and
hydrothermal/solvothermal process into production of fruit wastes derived metal nanoparticles. Recent
trends of researchers are towards nanosorbents for the removal of air and water pollutants along with
other fields by using fruit and food wastes material.
Synthesis of Nitrogen Doped Carbon Quantum Dots (NCQDs) from
Dieffenbachia seguine Leaves for Fluorescent pH Sensing
Authors: Rana A.S. , Negi P. , Rawat B.S. , Joshi N.C. , Upadhyay S. , Kumar N. , Sharma H. , Rawat P.S.
Published: February 2023

Synthesis with the goal of developing new fluorophores and characterizing them to find suitability for
various applications is of great importance in energy transfer in optoelectronics and biomedicine,
detection of metal ions, etc. In this study, a hydrothermal method was employed to synthesize nitrogen
doped carbon quantum dots (NCQDs) as pH sensor materials using Dieffenbachia seguine leaves as a
carbon source. A detailed characterization of the NCQDs revealed an absorption spectrum from 200
to 800 nm with multiple peaks and an energy-band gap of 3.58 eV. Carbon was found to have the
highest weight percentage, followed by nearly equal amounts of N and O and minor amounts of the
other elements. The analysis revealed the presence and crystal morphology of functional groups such
as OH, C=C and C–H. Variation of fluorescence intensity with pH was found in the pH range considered
from 1 to 10 with a correlation of 0.92. The results of these parameters support the utility of synthetic
NCQDs as fluorescent pH sensors.
Identification of Phytochemical Constituents in Phyllanthus acidus L.
Leaf through Gas Chromatography-Mass Spectroscopy as Biostimulant
Authors: Sangeetha K. , Swaminathan C. , Vellaikumar S. , Nivethadevi P. , Kannan P. , Subramanian E.
Published: February 2023

The Phyllanthus acidus L. belongs to the family phyllanthaceae and possess a wide range of secondary
metabolites and phytochemicals in leaves. To siphon off the use of synthetic chemicals in crop
production, an alternative like utilizing the natural bio-stimulants could play a crucial role in promoting
crop growth and development. The major goal of this study was to employ gas chromatography-mass
spectrometry to examine the bioactive compounds present in phyllanthus leaf and to identify and
characterize them utilizing dichloromethane as extraction solvent. According to GC-MS analysis,
dichloromethane extraction of phyllanthus leaf yielded, 25 phytoconstituents in which ethyl oleate
contributed the area percentage of 53.68%, hexadecanoic acid, ethyl ester by 17.47%, octadecanoic
acid, ethyl ester by 4.56%, squalene by 1.93% and cyclodecasiloxane, eicosamethyl- by 1.80% were
having the largest area coverage percentage. Since most of the phytoconstituents are growth stimulants,
it is suggested that phyllanthus leaf extracts be produced on a commercial scale as an exogenous
biostimulant for plant growth and development.
Synthesis of Novel 1,2,3-Triazolyl L-Serinol Palmitoyl Muramyl Dipeptide Derivatives
Authors: Alagodla Ramesh , Subba Reddy Paturu Rama , Vemireddy Sravanthi , Chaturvedi Devdutt , Sampath Kumar Halmuthur M.
Published: February 2023

In this research, a structural variant of muramyl dipeptide (MDP) is designed wherein, the entire
N-acetyl group was replaced by a bio-isosteric 1,2,3-triazole moiety with serinol lipid substitution at
4th position. The protecting groups such as benzyl and benzylidine were removed sequentially to
evolve three novel derivatives with increasing polarity as seen in the MDP-lipid 21-23 derivatives. A
synthesis strategy involving triazolyl click chemistry to combine MDP scaffold to the serinol lipid
head group is developed. The new derivatives were characterized using NMR, ESI-MS and MALDI.
Preliminary data from in vitro screening of the compounds inferred the immuno-potentiating properties.
Microwave-Assisted Synthesis of Ceria-Zirconia Nanoparticles:
Characterization and their Antimicrobial Studies
Authors: Ramasamy Tamilselvi , Arunachalam Thirumoorthi
Published: February 2023

Ceria-zirconia (CZAA) nanoparticles with varied molar ratio of 1:1, 0.8:0.2, 0.6:0.4, 0.4:0.6 and 0.2:0.8
labelled as CZAA-0, CZAA-1, CZAA-2, CZAA-3 and CZAA-4 were prepared using cerium nitrate,
zirconium nitrate and ascorbic acid as promoter. The X-ray diffraction, scanning electron microscopy,
ultraviolet-visible, Raman and Fourier transform infrared spectra were used to characterize the prepared
nanoparticles. The prepared CZAA nanoparticles were tested for antibacterial activity against
Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus and Enterococcus faecalis bacterial
strains as well as Aspergillus niger, Penicillium and Candida albicans fungal strains using the well
diffusion method. They were shown to be highly antimicrobial agents to all pathogenic strains tested.
Can We Use Our Dental Curing Lights to Polymerize Objects Produced with 3D Resin Printer?
Authors: Türkay Kölüş  , Mehmet Şahbaz  , Uğur Köklü
Published: February 2023

BACKGROUND

Dental treatment objects produced with 3D resin printers barely polymerize after fabrication. They need post-curing and an extra polymerization oven is required. Present study is aimed to determine the effectiveness of dental curing lights for post-curing of objects produced with a 3D resin printer.

METHODS

Samples were produced with Alias ​​Sharp & Rigid Model 3D Printing Resin in Photon Mono X 3D resin printer. The control set samples were cured with UV light for 2 min in Wash & Cure Plus device. T-20, T-40 and T-60 set samples were exposed to VALO Cordless curing light for 20, 40 and 60 seconds respectively. The hardness was measured with the Shore D Durometer. Then, the samples were subjected to compression. For statistical analysis, one way analysis of variance (ANOVA) and Tukey test was used.

RESULTS

The set cured with VALO Cordless for 20 seconds showed the highest strength. Compressive strength decreased with prolongation of the curing time. All experimental sets showed significantly higher hardness than the control set. Hardness increased gradually in the 20 and 40 second sets, but the difference between the 40 and 60 second sets was not significant. Also, color change was observed in the experimental sets samples.

CONCLUSIONS

Dental curing lights are effective in post-curing 3D printer resins.
Morphologic and Topographic Anatomy of the Nutrient Foramen in Human Long Bones and Its Clinical Significance
Authors: Gamze Taşkin Şenol  , Ibrahim Kürtül
Published: February 2023

BACKGROUND

The aim of the study was to evaluate the number and position of the nutrient foramina in tibia, fibula, femur, humerus, ulna, and radius bones of dry human bones and correlate the results clinically.

METHODS

For this purpose, 214 long bones were examined. Of the 214 bones studied, 31 were radial, 28 ulnar, 46 humeral, 33 tibial, 22 fibular and 54 femoral. The size, location and the number of nutrient foramina were analysed, and the length of the bone, and the distance of the nutrient foramina from the proximal end of the bone were measured. And the foraminal index was calculated.

RESULTS

The numbers of primary nutrient foramen (PF) and secondary nutrient foramen (SF) were 183 (85.5 %) and 16 (7.47 %), respectively, and distributed 80.64 % at radius, 92.85 % at ulna, 80.43 % at humerus, 93.93 % at tibia, 86.36 % at fibula, and 83.33 % at femur. The greatest number of SF was on the femur, but not on the tibia and fibula. A statistically significant correlation was seen among; TL-DPF (radius, tibia and femur), DPF-FI (radius, ulna, humerus, tibia, fibula and femur).

CONCLUSIONS

This study provides important information about the morphology of nutrient foramina in human long bones, knowledge of which will be useful to surgeons in planning orthopaedic procedures and useful to anthropologists in segmental analysis.
Prevalence of Influenza Virus in Patients with Severe Acute Respiratory Infections (SARI)
Authors: Debadatta Dhar Chanda  , Chhandasree Biswas  , Supriya Upadhyay
Published: February 2023

BACKGROUND

Influenza is viral fever with the main symptoms of the respiratory tract like cough, fever, breathlessness, nasal discharge, sore throat & myalgia. Pandemic 2009 H1N1 influenza A was the virus that presented a significant public health threat on a global scale. This prospective study was undertaken to analyse the prevalence of the influenza virus in patients with a severe acute respiratory infection (SARI) and also to determine the demographic characteristics and seasonal variations.

METHODS

This was a hospital-based prospective study done in the Department of Microbiology, Silchar Medical College & Hospital, Silchar for 1 year from June 2021 to May 2022. Respiratory specimens were tested for Influenza virus by one step real-time reverse transcription polymerase chain reaction (RT-PCR).

RESULTS

In real-time PCR, the influenza virus was detected in 6 out of 85 SARI patients (7%). Of 6 total positives, 4(67%) were influenza A and 2(33%) were influenza B. Among 4 influenza A positive cases, 3(75%) were influenza A (H1N1) pdm09 and 1(25%) was seasonal influenza A (H3N2). The highest percentage of positivity (50%) was detected in the age group of 15-29 years. The most common symptoms among the positive influenza cases were fever (100%), cough (88%), and breathlessness (56%). Other associated symptoms were sore throat (63%), nasal discharge (75%), and myalgia (75%).

CONCLUSIONS

This study clearly shows that influenza is an important cause of severe acute respiratory infection. It also suggests the need for continuous effective surveillance of influenza viruses to detect cases and control outbreaks. Early intervention and proper management of influenza virus cases are required to curb the disease burden.
Large Frontal Defect Reconstructed with a Suprafascial Anterolateral Thigh Flap and Brow Suspension with a Fascia Lata Frontalis Sling
Authors: Surya Rao Rao Venkata Mahipathy  , Manoj Ananthappan  , Narayanamurthy Sundaramurthy  , Anand Prasath Jayachandiran  , Alagar Raja Durairaj
Published: February 2023

A 60-year-old gentleman presented with a single, dark scaly lesion over the forehead for the past 8 years. It started as a small plaque spontaneously, insidious in onset and gradually progressed to the present size. There was no history of trauma, pain or bleeding from the lesion. No history of similar complaints in the family. On examination, there was a large hyperpigmented plaque measuring 15 x 10 cm with well-defined margins and rolled-out edges with ulceration 2 x 0.5cm at the centre. (Fig. 1) Edge wedge biopsy from the lesion revealed a proliferation of basaloid cells which showed features consistent with basal cell carcinoma - atypical mitosis and peripheral palisading.  After obtaining anaesthetic fitness, we proceeded with wide local excision with 1cm margin done by the surgical oncology team. (Fig. 2) We then followed by reconstruction of the frontalis sling using fascia lata and covered the defect with a free suprafascial ALT flap with superficial temporal as the recipient artery as an end-to-end anastomosis. (Fig. 3, 4) The donor site was resurfaced with SSG. The histopathology report was consistent with basal cell carcinoma without any perineural involvement. The early postoperative period showed the flap supple and soft with no oedema. (Fig. 5) On regular follow-up, the flap was well settled with good cosmesis. (Fig. 6)
DIGITAL MEDIA LITERACY AND SOCIAL MEDIA COMPETENCE AMONG MILLENNIALS FOR TOURISM PROMOTION DURING THE COVID PANDEMIC
Authors: Restaty Santa Margaretha Niken , Wuryanta AG Eka Wenats
Published: February 2023

This research started with the fall issue of tourism at a time when the pandemic strikes Indonesia. Much effort has been made to try to explore the possibility of a revival of Indonesian tourism. The millennial generation has the advantage of digital capabilities that can encourage tourism revival through social media. This study aims to find out to what extent the level of social media literacy can be a factor that encourages the participation of the younger generation, especially millennials, in helping the level of tourism promotion in Indonesia. The methodology used is quantitative with data collection using questionnaires. The population is Paramadina Univ students and Mercu Buana Univ students. The analysis used is frequency tables, correlation tests, and factor analysis. The essential findings obtained are that the generation is relatively high in the context of digital media literacy, and there are three supporting factors in the framework of involvement in tourism promotion, namely the ability to process digital media production, social collaboration capabilities, and the consistency of the millennial generation in developing social media production patterns.
Jakou školou jsme: newsletter jako nástroj utváření identity školy
Authors: Škarková Lucie , Kratochvílová Jana
Published: February 2023

V současnosti neutuchající trend zakládání soukromých škol vede i výzkumníky k prozkoumávání jejich identity a sebeutváření. V příspěvku se zabýváme tím, jak můžeme porozumět postupně se utvářející a prezentované identitě nově založené soukromé školy. Identitu školy zkoumáme se zřetelem ke skutečnosti, že jde o jev komplexní, významně procesního charakteru. Nahlížíme ji skrze newsletter, moderní formu přímého marketingu, kterým škola komunikuje se svými příznivci v on-line podobě. Datový materiál, který newslettery nabízejí, byl využit pro objasňování budování identity školy, která newslettery komunikovala s potenciálními zájemci a následně s rodiči svých žáků. Utvářenou identitu školy odhalujeme prostřednictvím kvalitativní obsahové analýzy informačních bulletinů. Výsledky induktivní analýzy poukazují na čtyři stěžejní charakteristiky identity: škola otevřená, spolupracující, sebeinspirující a osvětová, které se prolínají v ústřední kategorii kolektivní identity „škola jako mraveniště“. Charakteristiky kolektivní identity zkoumané školy jsou přenositelné i do jiných škol a výsledky výzkumu tak přinášejí inspiraci, jak je možné k budování identity školy přistupovat, v čem spočívají limity a co může kolektivní identita školy přinášet do komunikace všech aktérů školy.
Influence of natural and anthropogenic factors on the chemical composition of shallow groundwater in the city of Wrocław, south-west Poland
Authors: Trałka Marta , Błachowicz Marek , Buczyński Sebastian
Published: February 2023

Seen in the light of increasing anthropogenic impacts on the environment and a growing demand for potable water, pollution of groundwater is a very important issue, especially in large city areas. The present research includes analyses of the chemical composition at 109 measuring points in the Wrocław area, and of the spatial distribution of groundwater components with regard to land use, geological structure and hydrogeological conditions. Based on spatial analyses, it has been noted that changes depend mainly on land use and the kind of activity carried out in close proximity of water intake. Shallow groundwater in Wrocław is characterised by a great variability of main components. Factor analysis has made it possible to distinguish these components and determine the degree of their influence on the chemical composition of shallow groundwater in the entire study area. The current research demonstrates the high sensitivity of aquifers to pollution and emphasises the role of human activity in levels of groundwater pollution in urban areas.
Authors of articles published in Geologos in 2022 - brief information
Authors: Geologos Editors of
Published: February 2023

No abstract available.
Detection of moisture content in logs using multi-parameter GPR signal analysis and neural network models
Authors: Guo Jiaxing , Wang Peng , Qin Ruixia , Zhao Liming , Tang Xu , Zeng Jianyong , Xu Huadong
Published: February 2023

To address the low accuracy of non-destructive detection of moisture content (MC) of logs (especially in small diameters) by ground penetrating radar (GPR) signals, the MC of 10–15 cm diameter spruce, Manchurian ash, and white birch logs were predicted using the time-frequency parameters of the GPR signals and a back-propagation neural network (BPNN) model. B-scan signals were obtained using tree radar on the barks of discs selected from fresh green logs. Then, 31 time-frequency parameters from the B-scan signals were optimised using the least absolute shrinkage and selection operator (Lasso) and principal component analysis (PCA). Finally, the log MCs of the single and hybrid models was predicted using the BPNN. The accuracy of the least absolute shrinkage and selection operator and back-propagation neural network (Lasso-BP) were higher than those of the principal component analysis and back-propagation neural network (PCA-BP), and the BPNN. The individual species and hybrid models both have good predictive capability; when the log MC is below 20%, the maximum residual errors are relatively small, almost within 6% and 10%, respectively. These models significantly improve the accuracy of non-destructive detection of log MC and are beneficial for efficient wood processing.
On the quality checking of persistent scatterer interferometry data by spatial-temporal modelling
Authors: Omidalizarandi Mohammad , Mohammadivojdan Bahareh , Alkhatib Hamza , Paffenholz Jens-André , Neumann Ingo
Published: February 2023

Today, rapid growth in infrastructure development and urbanisation process increases the attention for accurate deformation monitoring on a relatively large-scale. Furthermore, such deformation monitoring is of great importance in the assessment and management of natural hazard processes like landslides, earthquakes, and floods. In this study, the Persistent Scatterer Interferometry (PSI) technique is applied using open-source Synthetic Aperture Radar (SAR) data from the satellite Sentinel-1. It allows point-wise deformation monitoring based on time series analysis of specific points. It also enables performing spatio-temporal area-based deformation monitoring. Currently, these data do not have a sophisticated quality assurance process to judge the significance of deformations. To obtain different quality classes of the Persistent Scatterer (PS) data points, the first step is to classify them into buildings and ground types using LoD2 building models. Next, time series analysis of the PS points is performed to model systematic and random errors. It allows estimation of the offset and the deformation rate for each point. Finally, spatio-temporal modelling of neighbourhood relations of the PS points is carried out using local geometric patches which are approximated with a mathematical model, such as, e.g., multilevel B-Splines. Subsequently, the quality of SAR data from temporal and spatial neighbourhood relations is checked. Having an appropriate spatio-temporal quality model of the PS data, a deformation analysis is performed for areas of interest in the city of Hamburg. In the end, the results of the deformation analysis are compared with the BodenBewegungsdienst Deutschland (Ground Motion Service Germany) provided by the Federal Institute for Geosciences and Natural Resources (BGR), Germany.
The crystal structure of 4-(pyren-1-yl)butyl-4-nitrobenzoate, C27H21NO4
Authors: Barrientos Claudio , Squella Juan Arturo , Moris Silvana
Published: February 2023

C27H21NO4, triclinic,P1‾$P\overline{1}$(no. 2),a = 7.3476(2) Å,b = 7.4894(2) Å,c = 20.5137(5) Å,α= 89.33000(10)°,β= 79.7070(10)°,γ= 67.5220(10)°,V = 1024.31(5) Å3,Z = 2,Rgt(F) = 0.0536, wRref(F2) = 0.1792, T = 296.15 K.
Analysis of thrombosis risk of commissural misaligned transcatheter aortic valve prostheses using particle image velocimetry
Authors: Borowski Finja , Kaule Sebastian , Oldenburg Jan , Schmitz Klaus-Peter , Öner Alper , Stiehm Michael
Published: February 2023

Due to excellent clinical results, transcatheter aortic valve replacement (TAVR) has evolved to a treatment option for patients with low surgical risk, resulting in an increasing demand for durable heart valve prostheses. Durability of TAVR could be limited by leaflet thrombosis. Thrombus formation in the aortic root is mainly affected by the hemodynamic situation, which is dependent on the positioning of the implant. We investigated the flow field in the aortic root after TAVR implantation by means of particle image velocimetry. To quantify the influence of the implant-position with respect to an alignment or misalignment of the leaflet commissures on the thrombogenic potential, we used a transport equation for residence time (RT) to consider washout behavior. Furthermore, we introduced a shear effect criterion (SIE) to address platelet activation as a measure for a potential thrombus formation. Misaligned implantation of a TAVR resulted in a reversed direction of rotation of the occurring recirculation area. This led to fluid flow with comparable areas of increased relative blood RT (RTaligned: 97.6%, RTmisaligned: 88.0%) and a smaller area of low shear load for the misaligned TAVR (SIEaligned: 57.7%, SIEmisaligned: 3.70%) into the sinus region, indicating a higher potential for thrombus formation.
Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease
Authors: Bhatnagar Akanksha , Krick Keegan , Karisetty Bhanu Chandra , Armour Ellen M. , Heller Elizabeth A. , Elefant Felice
Published: February 2023

The severity of Alzheimer's disease (AD) progression involves a complex interplay of genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT)-mediated neuroepigenetic mechanisms. While disruption of Tip60 HAT action in neural gene control is implicated in AD, alternative mechanisms underlying Tip60 function remain unexplored. Here, we report a novel RNA binding function for Tip60 in addition to its HAT function. We show that Tip60 preferentially interacts with pre-mRNAs emanating from its chromatin neural gene targets in theDrosophilabrain and this RNA binding function is conserved in human hippocampus and disrupted inDrosophilabrains that model AD pathology and in AD patient hippocampus of either sex. Since RNA splicing occurs co-transcriptionally and alternative splicing (AS) defects are implicated in AD, we investigated whether Tip60-RNA targeting modulates splicing decisions and whether this function is altered in AD. Replicate multivariate analysis of transcript splicing (rMATS) analysis of RNA-Seq datasets from wild-type and AD fly brains revealed a multitude of mammalian-like AS defects. Strikingly, over half of these altered RNAs are identified as bona-fide Tip60-RNA targets that are enriched for in the AD-gene curated database, with some of these AS alterations prevented against by increasing Tip60 in the fly brain. Further, human orthologs of several Tip60-modulated splicing genes inDrosophilaare well characterized aberrantly spliced genes in human AD brains, implicating disruption of Tip60's splicing function in AD pathogenesis. Our results support a novel RNA interaction and splicing regulatory function for Tip60 that may underly AS impairments that hallmark AD etiology.

SIGNIFICANCE STATEMENTAlzheimer's disease (AD) has recently emerged as a hotbed for RNA alternative splicing (AS) defects that alter protein function in the brain yet causes remain unclear. Although recent findings suggest convergence of epigenetics with co-transcriptional AS, whether epigenetic dysregulation in AD pathology underlies AS defects remains unknown. Here, we identify a novel RNA interaction and splicing regulatory function for Tip60 histone acetyltransferase (HAT) that is disrupted inDrosophilabrains modeling AD pathology and in human AD hippocampus. Importantly, mammalian orthologs of several Tip60-modulated splicing genes inDrosophilaare well characterized aberrantly spliced genes in human AD brain. We propose that Tip60-mediated AS modulation is a conserved critical posttranscriptional step that may underlie AS defects now characterized as hallmarks of AD.
EVOLUTION OF FERRO ELECTRIC AND FERRO MAGNETIC PROPERTIES OF RARE EARTH ALUMINIUM SUBSTITUTED M-TYPE BARIUM HEXA FERRITES AT ROOM TEMPERATURE
Authors:   Department of Physics, Lahore College for Women University, Lahore, Pakistan, SEHAR F. , ANJUM S. ,   Department of Physics, Lahore College for Women University, Lahore, Pakistan, MUSTAFA Z. ,   Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, China
Published: February 2023

The ferro-electric and ferro-magnetic properties of rare earth aluminium substituted Mtype barium hexa-ferrites with the composition of BaAlxFe(12-x)O19 where (x=0.2, 0.4, 0.6, 0.8, 1.0 and 1.2) have been prepared by oxides as precursors employing powder metallurgy route. The structural properties, functional groups, 3-D visualization, elemental analysis, surface morphology, magnetic, optical properties and ferro electric properties of the prepared samples have been characterized through X-Ray Diffractometer (XRD), Fourier Transform Infrared Spectroscopy (FTIR), diamond visualization software, Energy Dispersive Spectroscopy (EDS), Scanning Electron Microscopy (SEM), Vibrating Sample Magnetometer (VSM), UV-Visible spectroscopy (UV-VIS) and ZT-IA measurement system respectively. The structural measurements depict the confirmation of M-type barium hexa-ferrite structure. EDS spectrum illustrate the elemental composition of the prepared materials for every corresponding ‘x’ values. The surface morphology shows the existence of platelet like intergranular pores. Magnetic measurements shows that the saturation magnetization (Ms) decreases and coercivity (Hc) increases with increasing aluminium contents. The optical band gap energy increases as the crystallite size decreases. The variation of electric polarization has also been occurred due to the shifting of iron ions in the unit cell structure of oxygen octahedron FeO6.
THE POLY(ESTER AMINE)S FUNCTIONAL MAGNETIC CARBON NANOTUBES AS EFFICIENT GENE VECTOR
Authors:   School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, People’s Republic of China, ZHANG Q. , LONG Z. ,   School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, People’s Republic of China, FU H.L. ,   School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, People’s Republic of China, YAN G.P. ,   School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, People’s Republic of China, LI L. ,   School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, People’s Republic of China
Published: February 2023

Magnetic carbon nanotubes have been attracted great interest in biomedicine fields because of their unique structure and magnetic properties. A poly(ester amine)s functional magnetic CNT (CNTs/Fe3O4-HPEI) was prepared and used as gene carrier. The structure was confirmed by FTIR, XRD, TEM, and TGA. The poly(ester amine)s functional magnetic CNTs displayed typical superparamagnetic behavior. Plasmids can be bound by this poly(ester amine)s functional magnetic CNTs to form the nano complexes with positive charge. The gene transfection efficiency is related to the w/w ratio of CNTs/Fe3O4-HPEI and DNA. At the optimal w/w ratio of above 6, the poly(ester amine)s functional magnetic CNTs show a comparable transfection activity to 25k PEI, however the cytotoxicity is much lower. In addition, the gene transfection level can be improved in the magnetic field because of the increased cell internalization rate by magnetic force. These results suggest that the poly(ester amine)s functional magnetic CNTs would be a potential gene vector in targeted gene therapy.
EXPERIMENTAL STUDY OF OXYGENATED ADDITIVE IN DIESEL-WASTE PLASTIC OIL-PROPANOL BLEND OPERATED IN A SINGLE-CYLINDER DIESEL ENGINE
Authors:   School of Mechanical Engineering, Sathyabama Institute of Science and Technology, Chennai, India, RAVI S. , KARTHIKEYAN A. ,   School of Mechanical Engineering, Sathyabama Institute of Science and Technology, Chennai, India, JAYAPRABAKAR J. ,   School of Mechanical Engineering, Sathyabama Institute of Science and Technology, Chennai, India
Published: February 2023

Novel fuel blend made of diesel, waste plastic oil, propanol, and di-tert-butyl peroxide (liquid additive) is used in diesel engine thereby diminishing diesel consumption and improving performance and emission characteristics. In this study, diesel was blended with waste plastic oil, propanol, and di-tert-butyl peroxide as liquid additive at different proportions in order to improve its physio-chemical properties. Blend ratios of test fuels used in this work were 100% of Diesel, 80% of Diesel-20% of Waste plastic oil (DW), 70% of Diesel-20% of Waste plastic oil-10% of Propanol (DWP), 60% of Diesel-20% of Waste plastic oil-10% of Propanol-10% of di-tert-butyl peroxide (Additive) (DWPA). On comparing with diesel fuel, average brake specific fuel consumption and brake thermal efficiency of DWPA blend increased by 11.96% and 8.78% respectively, It was also shown that the average brake specific CO and HC emissions of DWPA blend increased by 3.87% and 15.7% respectively, however brake specific NOx and smoke emissions of DWPA blend reduced by 8.08% and 35.36% respectively due to addition of liquid additive as di-tert-butyl peroxide.
THE EFFECT OF ZnO/NiO NANOCOMPOSITE ON THE PROPERTIES OF A PHOTOELECTRODE OF A DYE SENSITIZED SOLAR CELL
Authors:   Department of Engineering Materials and Biomaterials, Silesian University of Technology, Konarskiego 18a Str., 44-100 Gliwice, Poland, SZINDLER M. , SZINDLER M. M. ,   Department of Engineering Materials and Biomaterials, Silesian University of Technology, Konarskiego 18a Str., 44-100 Gliwice, Poland
Published: February 2023

The aim of the article was to investigate the structure and optical and properties of the ZnO/NiO nanoparticle layer with a different percentage of individual components produced by the sol-gel method. The influence of the developed layers on the properties of dye sensitized solar cells was also determined. Phase identification of the ZnO and NiO samples was confirmed by X-ray diffraction and TEM analysis. From the synthesized nanoparticles, a ZnO/NiO layer was prepared by screen printing method. Studies of the surface morphology of this layer from as prepared nanoparticles, deposited on an FTO glass substrate, was performed by using scanning electron microscopy. Current-voltage characteristics of dye-sensitized solar cells with ZnO/NiO layer and platinum counter electrodes were performed using PV Test Solutions Tadeusz Żdanowicz Solar Cell I-V Tracer System with solar simulator and Keithley 2400 source meter. The best results were obtained for a solar cell containing a ZnO/NiO nanocomposite with 70/30 ratio and its efficiency was 4.46%.
PHYSIOCHEMICAL PROPERTIES OF TIN OXIDE THIN FILMS DEPOSITED BY SPRAY PYROLYSIS
Authors:   PG & Research Department of Physics, Government Arts College (Autonomous), Kumbakonam 612002, Tamilnadu, India (Affiliated to Bharathidasan University, Tiruchirappalli, Tamilnadu, India), JANAKIRAMAN V. , TAMILNAYAGAM V. ,   Department of Physics, A.P.A. College of Arts & Culture, Palani, Dindigul, Tamilnadu, India, SUNDARARAJAN R. S. ,   PG & Research Department of Physics, Government Arts College (Autonomous), Kumbakonam 612002, Tamilnadu, India (Affiliated to Bharathidasan University, Tiruchirappalli, Tamilnadu, India), SIVABALAN S. ,   Department of Physics, T.B.M.L. College, Porayar 609307, Tamilnadu, India, SATHYASEELAN B. ,   Department of Physics, University College of Engineering Arni (A Constituent College of Anna University Chennai) Arni 632326, Tamil Nadu, India
Published: February 2023

In this article, tin oxide film is deposited onto glass substrates at 350ºC by spray pyrolysis technique. The nature of nanoparticles is investigated using X-ray diffraction, UV-visible spectroscopy, and Fourier transforms infrared spectra. XRD studies are shown that the thin film orientations along (110), (101), (200), (211), (220), (310), (301), and (321) planes. The phase structure is polycrystalline with tetragonal rutile. The average crystallite sizes are determined. Field emission scanning electron microscopy analysis shows that SnO2 thin film with irregular grains and irregular shapes was found. A Fourier transform infrared spectra characteristics for pure SnO2 thin films explains various vibrational assignment modes. Energy dispersive spectroscopy analysis confirms the elements of deposited thin films on the glass substrate. UV visible absorption spectra show that the band gap of SnO2 thin film is 3.57 eV. The SnO2 thin films are prepared using a simple and economical technique with the advantage that they are used for optoelectronic devices and gas sensor applications.
A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling
Authors: Zhu Lingxin , Tang Yi , Li Xiao‐Yan , Kerk Samuel A , Lyssiotis Costas A , Feng Wenqing , Sun Xiaoyue , Hespe Geoffrey E , Wang Zijun , Stemmler Marc P , Brabletz Simone , Brabletz Thomas , Keller Evan T , Ma Jun , Cho Jung‐Sun , Yang Jingwen , Weiss Stephen J
Published: February 2023

Osteoclasts are bone‐resorbing polykaryons responsible for skeletal remodeling during health and disease. Coincident with their differentiation from myeloid precursors, osteoclasts undergo extensive transcriptional and metabolic reprogramming in order to acquire the cellular machinery necessary to demineralize bone and digest its interwoven extracellular matrix. While attempting to identify new regulatory molecules critical to bone resorption, we discovered that murine and human osteoclast differentiation is accompanied by the expression of Zeb1, a zinc‐finger transcriptional repressor whose role in normal development is most frequently linked to the control of epithelial‐mesenchymal programs. However, following targeting, we find that Zeb1 serves as an unexpected regulator of osteoclast energy metabolism. In vivo, Zeb1‐null osteoclasts assume a hyperactivated state, markedly decreasing bone density due to excessive resorptive activity. Mechanistically, Zeb1 acts in a rheostat‐like fashion to modulate murine and human osteoclast activity by transcriptionally repressing an ATP‐buffering enzyme, mitochondrial creatine kinase 1 (MtCK1), thereby controlling the phosphocreatine energy shuttle and mitochondrial respiration. Together, these studies identify a novel Zeb1/MtCK1 axis that exerts metabolic control over bone resorption in vitro and in vivo.
Targeting the liver to treat the eye
Authors: Seker Yilmaz Berna , Gissen Paul
Published: February 2023

Over the last two decades, gene therapy has given hope of potential cure for many rare diseases. In the simplest form, gene therapy is the transfer or editing of a genetic material to cure a disease via nonviral or viral vehicles. Gene therapy can be performed either in vivo by injecting a vector carrying the gene or tools for gene editing directly into a tissue or into the systemic circulation, or ex vivo when patient cells are genetically modified outside of the body and then introduced back into the patient (Yilmaz et al, 2022). Adeno‐associated viral vectors (AAV) have been the vectors of choice for in vivo gene therapy. There has been a lot of promising research on the development of novel tissue and cell‐specific serotypes in order to improve efficacy and safety for clinical applications (Kuzmin et al, 2021). In this issue of EMBO Molecular Medicine, Boffa and colleagues present a novel AAV‐based liver‐directed gene therapy for ornithine aminotransferase deficiency.
PROGRAM PUBLIC PRIVATE MIX (PPM) TUBERKULOSIS PADA FASILITAS KESEHATAN DI KOTA SEMARANG
Authors: Rahayu Sri Ratna , Azam Mahalul , Indrawati Fitri , Affandi Mustafa Daru , Merzistya Aufiena Nur Ayu , Wandastuti Anggun Dessita , Isbandi Isbandi , Laila Annisa Khoirul , Aulia Atika
Published: February 2023

Peran sektor swasta yang tinggi dalam penyediaan pelayanan kesehatan tidak beriringan dengan peran penemuan kasus TB. Rendahnya peran swasta memerlukan penguatan jejaring sektor publik dan swasta yang disebut Public Private Mix (PPM). Peningkatan pemahaman akan peran sektor swasta dan publik dalam penemuan kasus diperlukan sehingga memperkuat manajemen program di pelayanan kesehatan dalam penemuan kasus. Tujuan penelitian ini untuk mengetahui informasi mendalam dan menganalisis peran pelayanan kesehatan publik maupun swasta di Kota Semarang terhadap pelaksanaan program PPM dari perspektif tenaga kesehatan. Penelitian ini dilakukan dengan rancangan cross sectional survey. Sebanyak 35 tenaga kesehatan Puskesmas dan 5 tenaga kesehatan klinik swasta sebagai sampel penelitian dengan teknik purposive sampling. Analisis data dilakukan secara kuantitatif dengan uji deskriptif dan uji Chi Square. Hasil penelitian ini diketahui bahwa dari sejumlah 35 fasilitas kesehatan baik fasisiltas publik (pemerintah) maupun privat (swasta), dengan 38 petugas TB di Puskesmas dan 5 petugas kesehatan di Klinik Swasta. Hasil penelitian ini menujukkan sebagian besar fasilitas kesehatan memiliki pengetahuan yang baik mengenai diagnosis, pengobatan, dan pencatatan dan pelaporan TB. Usia, jenis kelamin, pendidikan, pengalaman kerja, dan lama kerja pada tenaga kesehatan di Puskesmas dan klinik tidak memiliki hubungan yang signifikan dengan pengetahuan diagnosis, pengobatan, serta pencatatan dan pelaporan sebagai penunjang penegakkan kasus TB dan upaya PPM. Meski demikian, lebih dari 50% tenaga kesehatan Puskesmas dan Klinik bersedia memberikan pelayanan TB melalui DOTS, pendistribusian Obat Anti TB (OAT), melakukan pencatatan dan pelaporan secara rutin, serta bersedia dalam pelaksanaan Pengawas Menelan Obat (PMO).
BRANCHED CHAIN AMINO ACID (BCAA), SITRULIN, BROMELAIN DAN MUSCLE INJURY
Authors: Mardiana Mardiana , Khofifah Nur , Lestari Yanesti Nuravianda
Published: February 2023

BCAA merupakan salah satu jenis asam amino yang banyak terdapat di dalam minuman olahraga atau sport drink. Beberapa hasil penelitian menunjukkan bahwa BCAA secara efektif dapat dapat meningkatkan daya tahan kapasitas latihan, meningkatkan sintesis protein, mengurangi kelelahan otot, melemahkan pemecahan protein otot diinduksi oleh olahraga, dan membantu pemulihan dari kerusakan otot. Selain itu, kandungan sport drink yang baru-baru ini banyak dilakukan penelitian ialah sitrulin dan bromelain.  Sitrulin merupakan asam amino non esensial, yang berperan dalam meningkatkan kadar nitrit oksida yang dapat meningkatkan system aliran darah, metabolisme energi otot, dan respirasi mitokondria saat berolahraga, sedangkan bromelain merupakan bahan alami yang kompleks mengandung enzim proteolitik yang berasal dari nanas (Ananas cosmosus).
GAMBARAN EKOLOGI VEKTOR DEMAM BERDARAH DENGUE DALAM PENELUSURAN KASUS COVID-19 DI DAERAH ENDEMIS DBD KOTA TEMANGGUNG
Authors: Sukendra Dyah Mahendrasari , Santi Yunita Dyah Puspita , Siyam Nur , Hermawati Bertakalswa , Norisa Farah Veda , Setyaningsih Indriyani Agus , Rozana Syntia Veronica , Shiddieqy Muhammad Hasbi Ash , Puspitarani Fitriana
Published: February 2023

Dampak signifikan dari co-sirkulasi virus dengue dengan COVID-19 pada sistem kekebalan tubuh. Pengetahuan mengenai tanda-tanda awal / gejala klinis kasus dapat membantu mencegah terjadinya keparahan penyakit yang lebih berat karena terjadi koinfeksi. Penemuan kasus COVID-19 di  wilayah endemis DBD pun sering terjadi. Pembatasan jarak sosial sebagai pencegahan penularan COVID-19, dapat berdampak pada kejadian DBD. Tujuan dilakukannya penelitian ini untuk mendapat gambaran ekologi vektor Demam Berdarah Dengue dalam penelusuran kasus Covid-19 di wilayah endemis DBD. Penelitian dilaksanakan daerah Kota Temanggung yang termasuk wilayah endemis DBD.  Penelitian dilaksanakan dengan desain observasi analitik. Responden dipilih berdasarkan kriteria tertentu. Deskripsi ekologi vektor DBD didapat dengan menganalisa data sekunder serta primer dalam penelusuran kasus Covid-19 di daerah endemis DBD di Kota Temanggung. Hasil penelitian menunjukkan bentuk topografi cekungan atau depresi mendominasi  wilayah Kabupaten Temanggung. Daerah berbentuk pegunungan dan bukit dengan wilayah dataran lebih rendah dibagian tengah. Kejadian DBD maupun Covid-19 lebih banyak terjadi pada lahan pemukiman daripada lahan lainnya. Hal ini dapat dipengaruhi oleh kepadatan penduduk, kebersihan lingkungan, aktivitas warga.  Ditemukan ada 7 wilayah kerja puskesmas di Kabupaten Temanggung terdapat kasus Covid-19 dengan riwayat DD dan DBD. Dominasi penderita DBD sebanyak 84,49%  berada di wilayah dengan status endemis di tingkat desa maupun kelurahan. Sebanyak 7 kecamatan berstatus wilayah endemik ditemukan  kasus Covid-19 dengan riwayat pernah positif DBD dan DD.
"En Turania" de Ciro B. Ceballos: retrato de los modernistas mexicanos
Authors: Pellicer Rosa
Published: February 2023

Los retratos que componen En Turania son una defensa de los ideales artísticos y de las obras de los jóvenes escritores y artistas mexicanos que se reunieron en torno a la primera época de la Revista Moderna. En este estudio se consideran las características de estas semblanzas en las que Ceballos se convierte también en personaje, el cambio en la valoración de los integrantes del grupo modernista y de su ideal estético, así como su posterior alejamiento.
Parameter analysis on longitudinal lateral force resistance of Song dynasty timber frame with Panjian
Authors: Chang Yibin , Dai Jian
Published: February 2023

The Panjian structure is an important longitudinal connecting member of Song Dynasty hall-type buildings in China. To study the lateral force resistance of such structures, a refined finite element model of Song-style hall-type single-room four-column space timber frame containing Panjian structure was established based on the official building code Yingzao Fashi of Song Dynasty. The Panjian and inner E’fang in the lower-ping part, the Panjian in the upper-ping part, and Guazi-gong Panjian and Man-gong Panjian in the roof ridge part were investigated. The model hysteresis curves of all three parts of the longitudinal timber frame were found to be S-shaped, with obvious pinching effect, fuller at both ends and centrosymmetric shape. The Panjian structures in the lower-ping and upper-ping parts, and the Guazi-gong Panjian in the roof ridge part increased the energy dissipation and lateral stiffness of the timber frame. The Man-gong Panjian in the roof ridge part, however, was detrimental to the lateral resistance of the structure. Throughout the test, the Panjian structures were relatively intact, with large plastic damage occurring at both ends of the E’fang. For the repair and testing of similar ancient buildings, some reference suggestions are provided.
INCREASING THE EFFICIENCY OF THE SURFACE-MOUNTED ULTRASONIC ELECTROMAGNETIC-ACOUSTIC TRANSDUCER ON ACCOUNT OF THE MAGNETIC FIELD SOURCE
Authors:   National Technical University “Kharkiv Polytechnic Institute”, 2, Kirpichova str., Kharkiv, 61002, Ukraine, Suchkov G.M. , Bolyukh V.F. ,   National Technical University “Kharkiv Polytechnic Institute”, 2, Kirpichova str., Kharkiv, 61002, Ukraine, Kocherga A.I. ,   National Technical University “Kharkiv Polytechnic Institute”, 2, Kirpichova str., Kharkiv, 61002, Ukraine, Mygushchenko R.P. ,   National Technical University “Kharkiv Polytechnic Institute”, 2, Kirpichova str., Kharkiv, 61002, Ukraine, Kropachek O.Yu. ,   National Technical University “Kharkiv Polytechnic Institute”, 2, Kirpichova str., Kharkiv, 61002, Ukraine
Published: February 2023

Model studies were carried out using the COMSOL Multiphysics package, aimed at ensuring the forming of a permanent magnet magnetic field at a considerable distance to a ferromagnetic product from its pole, which is necessary to create efficient portable ultrasonic electromagnetic-acoustic transducers of thickness gauges and testing and diagnostic devices. It is theoretically shown and experimentally confirmed that for portable measuring ultrasonic devices it is expedient to set the height of the permanent magnet at about 60 mm and the cross section of the magnet pole 50x50 mm2. At the same time, with a gap between the magnet pole and the product of about 30 mm, the value of the normal component of the magnetic field induction near the surface of the object is about 0.3...0.4 T, which is sufficient for thickness gauging or diagnostics of ferromagnetic products using the ultrasonic pitch-and-catch method. References 19, figures 8.