bluuebunny/crossref_metadata_2025 huggingface dataset:
Online Exams in Language, Linguistics and Translation Courses During the Pandemic in Saudi Arabia
Authors: Al-Jarf Reima
Published: September 2022

At Saudi universities, there was a sudden shift from face-to-face instruction to distance learning and assessment in March 2020 due to the COVID-19 Pandemic. This study explored the status of online exams in language, linguistics, and translation courses in the first two semesters of the Pandemic (Spring 2020 and Fall 2020). Analysis of faculty surveys and students’ comments on Twitter showed that the main concern of 91% of the students was final exams and passing courses with high grades. Students were worried about the negative effect of online exams on their GPA. Since the students were not familiar with online exams taken via Blackboard, they were anxious and wondered if they would do well. Some cheated on online exams as their cameras were turned off. Numerous adjustments were mandated by university administrations to alleviate students’ anxiety such as allocating 20% of the course mark to the final exam, allowing more exam time, giving projects, open-book exams, term papers, reports, assignments or giving a presentation instead of the final. Some instructors gave easy questions and were lenient in grading to avoid students’ complaints. They gave no essay, just objective questions. The students were given the option to drop the course, to choose a letter grade, pass/fail, i.e., no grade, or to have a course mark included in their GPA. Based on faculty surveys, this study reports challenges of online exams during the Pandemic, design and delivery of online exams, assessment forms and choices, grade inflation issues, and lessons learned and some recommendations.
Altered Stories, Altered Lives: An Exploration of Post Traumatic Growth from A Narrative Perspective with a Strengths Based Focus
Authors:   , Jones Andrea
Published: September 2022

Complex trauma is prevalent, underrecognized, and difficult to treat. Left untreated, the ongoing negative consequences impact individuals, families and society. Literature indicates traditional modes of treatment for post-traumatic stress disorder have high attrition rates and are ineffective for approximately 30% of clients (Schouten et al., 2018). Art Therapy provides the opportunity to offer effective, well tolerated treatment for ongoing adverse consequences of trauma symptoms and recontextualization of the trauma due to the highly nonverbal nature of trauma memory (Hass-Cohen et al., 2014). A nested mixed methods design (Neubauer et al., 2019) combining arts-based research with pre and posttest survey analysis gathered detailed, phenomenological information from a single case study of a 60-year-old female trauma survivor. This study investigated her experience of trauma and movement towards post traumatic growth through the collection of data from art, participant feedback, and survey analysis. Results from this single case narrative, arts based inquiry produced improvements in several post-trauma recovery markers (Hass-Cohen et.al, 2014) including self-identified character strengths and yielded support for the significance of the fear/shame bind which is often hidden from consciousness even for clients who have undergone intensive trauma treatment. Further research using the nested mixed methods approach is needed to understand the fear/shame bind including adaptation to groups, which could provide a deeper understanding of the benefits of ongoing recovery support.
Investment activity of enterprises in covid-19 crisis
Authors: Atamas H. , Petrenko O.
Published: September 2022

covid-19 pandemic has brought some changes to the economy that have contributed to a sharp drop in investment. It is established that in the period of high uncertainty caused by the spread of coronavirus, the most important and promising source of recovery and development of enterprises is investment. Issues (problems) of theoretical and practical direction in the development of investment activities of enterprises in various sectors of the economy are considered in this paper particularly, retrospective analysis of investment activities of enterprises in Odessa region. Thus, the decrease in the total value of real investments of enterprises for the three-year period (2018–2020) is determined. The highest demand for investment was observed in such sectors as transport, warehousing, postal and courier activities (20%), industry (19.2%), warehousing and ancillary activities in the transport sector (18.2%). Peculiarities of investment activity of enterprises in crisis conditions are revealed. From the point of view of the global situation, which affects the prospects of investment, there are three main areas: agriculture (consumer products), information and communication technologies and the pharmaceutical industry. The need to plan the activities of enterprises to restore the investment process is revealed. Effective investment promotion requires choosing the right focus of industries. In order to avoid negative trends in investment, it is necessary to find stabilizing factors to increase the level of their volume. In the normal situation, this is primarily the improvement of financial and budgetary policies of the state and regions, the fight against inflation, reforms in the banking system, tax incentives and more. Investments in information and communication technologies and the pharmaceutical industry have been identified as key areas of investment in the near future. Projects in the field of digital technologies will also be the most attractive for investors. The need for state-supported enterprises should also be noted. These measures will make it possible to concentrate the efforts of the state and public-private initiative to overcome the economic consequences of covid-19 pandemic and restore the investment climate in the country and its regions.
Analysis and evaluation of the execution of local budgets of territorial communities of the Volyn region, as a component of ensuring their competitiveness
Authors: Podzizei O. , Shmatkovska T.
Published: September 2022

The reform of the local self-government system and budget decentralization in Ukraine resulted in the creation of full-fledged united territorial communities, which received additional budgetary powers and sources of filling budgets to ensure the achievement of sustainable development goals. Thus, UTC also has additional opportunities to attract investment for community development. In addition, there are growing opportunities to promote local businesses, the effectiveness of which depends on the filling of community budgets. Accordingly, there is an objective need to assess the effectiveness of the functioning of the united territorial communities in the first budget year after the completion of the main stage of decentralization. At the same time, based on the assessment of performance indicators of budget revenues and expenditures, as well as taking into account its surplus or subsidies, it is possible to make a conclusion about the effectiveness of budgetary and administrative reform. In addition, such analysis makes it possible to obtain data that can characterize the level of competitiveness of UTC in comparison with other communities in the region. The modern features of the functioning of the united territorial communities in the new budget conditions are considered in this paper. The volumes of receipts and expenditures of the general fund of budgets of UTC of Volyn region are investigated and analyzed. Comparison of revenues and expenditures of the general budget per capita is carried out. Based on the obtained results, the subsidy of the budgets of territorial communities is assessed. It is determined that in Volyn region only 21.6% of all united territorial communities have excess of revenues over expenditures or are unprofitable. Research on the territorial regularity of the location of subsidized and profitable UTCs, when in the northern districts of the region are located, mostly subsidized communities, and in the south – more profitable. Based on the analysis, a set of measures aimed at the overall increase of budget efficiency of territorial communities, which should ensure the overall growth of their competitiveness in the future is proposed.
Efficiency of the use of land resources of agricultur.al enterprises in Ukraine
Authors: Filiuk D. , Shmatkovska T. , Borysiuk O.
Published: September 2022

The world is constantly changing, but the desire of a man and country for security remains unchanged, which certainly includes economic and social components. In emergencies, the challenges of social security become even more urgent, because the leveling of risks will contribute to the development and quality of human existence, the country, and if it is impossible to overcome the negative consequences in this area will delay the future. Therefore, the aim of the investigation is to analyze the socio-economic determinants that determine social security in today's global environment. Based on the author's methodology for assessing the level of social security, markers and indicators of social security are analyzed by groups: labor market, material well-being, quality of social and labor relations, identified environmental component as part of human security. The results of the investigation show the increase in risks in the labor market due to reduced employment opportunities, as evidenced by statistics on unemployment and the workload per vacancy. The instability of the labor market ecosystem, which has emerged from the covid-19 epidemic and is now exacerbated by hostilities, demonstrates the widening of labor market imbalances. As a result, the risks of social security in the group of material well-being increase. In particular, there is a growing trend of poor people, increasing opportunities for people to develop and maintain good health. Unfortunately, there are simultaneous processes of increasing pressure on the state to ensure sufficient level of social guarantees. Conditionally stable are the indicators of social security in the group of quality of social and labor relations, where there is satisfactory level of trust in social dialogue, adapted and selected the most effective methods of communication and introduced mixed regulations for work in enterprises. The assessment of the environmental component of human social security demonstrate the lack of efforts to ensure the livelihood of the population. Thus, in general, the new dimension of social security in the global environment involves the socio-economic aspects of human life, which are certainly related to the development of human capital and compared with the goals (their achievement) to preserve labor potential.
Organizational and informational model of analysis of the financial condition of credit union
Authors: Gerbych L. , Buznyk M.
Published: September 2022

The relevance of conducting regular analysis of the financial condition of credit unions as a necessary element of confirming their financial resources for further effective business activities is substantiated. The necessity of building an organizational and information model of such analysis, which includes the purpose and objectives, subjects and objects, system of indicators, information base, methodological support of the analysis and methods of generalization and implementation of its results is proved. The purpose of the analysis of the financial condition of credit union is to identify in a timely manner the factors that cause its deterioration and develop measures to eliminate or minimize their negative impact. The tasks of the credit union's financial condition analysis include the analysis of assets, liabilities, liquidity, solvency, efficiency and profitability. The subjects of the analysis of the financial condition of credit union are divided into external and internal. External entities include the regulator represented by the National Bank of Ukraine; customers; partners; fiscal, judicial authorities; internal ones - governing bodies, collegial and territorial governing bodies, employees of executive units with the functions of financial management. The main indicators of the analysis of the financial condition of credit union are divided into such groups as capital adequacy, asset quality, liquidity, efficiency and profitability and proposed an algorithm for calculating them are proposed in accordance with the requirements of the rules for preparing and submitting reports by participants of the non-bank financial services market, introduced since the beginning of 2022.The information base of the analysis of the financial condition of credit unions as a set of sources of internal and external information, which include financial and statistical reporting, as well as operational data of financial accounting; indicators of credit unions published by the NBU both in the market as a whole and by institutions on a quarterly basis, as well as information on the activities of credit unions posted on the websites of self-regulatory organizations are noted. The review of existing methods for assessing the financial condition of credit unions as its methodological support is carried out and promising area of research for their further improvement is identified. Measures to increase the financial condition of credit unions of Ukraine are proposed.
Decolonizing Librarians’ Teaching Practice: In Search of a Process and a Pathway
Authors: Laverty Corinne , Berish Francine
Published: September 2022

Many educators across post-secondary institutions are learning about their colonial histories and the need to decolonize curriculum, learning materials, and teaching practice described in the Truth and Reconciliation Commission of Canada: Calls to Action (2015). This qualitative study explored the meaning of decolonizing with a group of ten instruction librarians at a mid-sized Canadian institution. The project was conducted in the form of a learning program to offer the predominantly white settler librarian participants a chance to explore these topics. It provided an opportunity to document a learning process and a pathway to initiate change. A five-month learning program uncovered participant questions and interpretations of decolonizing drawing on transcripts of individual learning journals and a focus group as the data set. The program inspired a community of practice enabling the learning and unlearning essential to decolonizing. We report, from the perspective of two white settler librarians, on the meaning of decolonizing as an ongoing process that enables awareness of colonization, personal identity, and positionality and includes strategies librarians can use on the path to decolonizing teaching, collections, and spaces. Participant self-awareness surfaced a critical librarianship mindset where information is understood as a product shaped by cultural, historical, social, and political forces, and where we acknowledge that academic libraries and their information sources and systems are not neutral and empower specific voices.
Anthropometric study of facial indices among Bangladeshi women
Authors: Farhat Nazma , Rahman SM Niazur , Albarune Abu Raihan , Alam Tanbira
Published: September 2022

Background: Craniofacial anthropometric values and indices are vital for experts from different walks of science. Variations in such values are evident in racial and geographical attribute. Furthermore, anthropological classification would assist clinicians in planning regional surgeries, forensic identification and many more.
Objective: In this study we aimed to measure the head-face landmarks in a particular population and to correlate their association.
Methodology: To assess intra population variation, the fronto-occipital circumference, facial height, bizygomatic breadth, bitragion breadth, bigonial breadth, width of mouth, intercanthal width, biocular breadth and body height of 100 Bangladeshi women (age 25-45 years) were measured and craniofacial indices were calculated. Frequencies were observed while comparing the variables by ANOVA using SPSS version 17.
Result: The mean values of facial indices revealed as prosopic index 103.8 ± 12cm, zygomandibular index 81.1 ± 7.44cm, canthal index 36.93 ± 2.3cm and circumference-interorbital index 2.26 ± 0.4cm. 86% of subjects were clustered to hyperleptoprosope group (very narrow face) and 69% had wide jaw with closely placed eyes. No significant (p>0.05) correlation was denoted between variables and facial indices.
Conclusion: The result of this study would provide an access to baseline data of local standards for anthropometric evaluation which might help the clinicians in planning regional surgeries and forensic experts in identification.
Northern International Medical College Journal Vol. 12 No.1 July 2020, Page 503-506
Gestión de la cadena de suministro: presiones, prácticas y desempeño del sector manufacturero
Authors: Lema-Ruiz Evelyn , Hurtado-Yugcha Jacqueline
Published: September 2022

La gestión de la cadena de suministro verde (GCSM) ha transformado el enfoque empresarial como una clave para volverse ambientalmente sostenibles. Este trabajo tiene como objetivo evaluar y describir los impulsores, las prácticas y el rendimiento de la GCSM entre varias organizaciones de fabricación ecuatorianas de la provincia de Tungurahua. El método utilizado se originó sobre la base de una revisión de la literatura, pues, se completó un estudio empírico mediante la utilización de encuestas. El cuestionario fue estructurado por 54 ítems según los aportes validados de expertos en la industria. Se utilizó la técnica estadística del análisis factorial exploratorio para derivar agrupaciones de presiones, práctica y desempeño de GCSM a partir de los datos de la encuesta que incluyeron 314 respuestas. Los hallazgos revelaron que, las empresas tungurahuenses han aumentado su conciencia medioambiental debido a las presiones y los impulsores regulatorios, competitivos y el marketing. Sin embargo, esta conciencia no se ha traducido en una sólida adopción de la práctica de GCSM, y mucho menos en mejoras en algunas áreas de desempeño, donde se esperaba.
Gestión universitaria en los procesos de auditoría interna y su influencia en la administra-ción de instituciones públicas
Authors: Quiroz-Báez Narcisa del Rocío , Mendoza-Fernández Verónica
Published: September 2022

El objetivo del estudio se fundamenta en analizar la gestión universitaria en los procesos de auditoría interna, y su influencia en la administración de instituciones públicas. El diseño de la investigación se desarrolla bajo un enfoque cualitativo, de tipo documental, en el cual se analiza la incidencia de la auditoría interna en el ámbito del control interno de las instituciones de educación superior, partiendo de la documentación teórica y el análisis de la información recopilada sin la manipulación de variables. La población objeto de estudio se sustenta en documentos tipo artículos científicos, trabajos de investigación y material referencial bibliográfico. Para recabar los datos se emplean fichas de contenido, las cuales representan la base para el análisis de contenido de las fuentes consultadas. Con el análisis de los resultados, se pretende realizar una indagación de los aspectos teóricos que fundamentan a la gestión universitaria, visualizada desde las nociones de auditoría para accionar en los controles que se deben llevar administrativa, contable y a novel gerencial en las universidades ecuatorianas.
Análisis organizacional de las Aduanas en Ecuador, durante la pandemia Covid 19 periodo 2020 - 2021
Authors: Ramírez-Gallardo María , Arias-Montero Jorge
Published: September 2022

La crisis sanitaria mundial afectada por la pandemia de COVID-19 anunciada el 11 de marzo del 2020 presenta enormes desafíos para todos los países desarrollados y en vías de desarrollo, incluido Ecuador, donde su sistema de salud se pone a prueba y sus problemas económicos y sociales se profundizan. Para el Ecuador el comercio internacional es una fuente de mejora económica, es por el bienestar de las economías que deben especializarse y aprovechar los beneficios que nos traerán. Un claro ejemplo es que Ecuador es un país que no produce bienes derivados de los metales, y por lo tanto debe importar dichos bienes. Por ello, en una economía como la ecuatoriana, las medidas restrictivas a la libre entrada de insumos importados han afectado en gran medida el crecimiento de los sectores importadores y/o productores de otros bienes que se benefician de la importación con este tipo de bienes, y ese es el caso en la aplicación de salvaguardas arancelarias. La investigación tiene como objetivo principal determinar el análisis organizacional de las aduanas en Ecuador, durante la pandemia Covid-19 periodo 2020-2021. Para esta investigación se utilizó una herramienta cuantitativa en la cual se realizó una comparación de datos sobre los años 2019,2020 y 2021 sobre las exportaciones e importaciones totales para ver como afecto el covid-19 en las aduanas en el Ecuador.
Palabras clave: Comercio internacional; Covid-19; exportaciones; importaciones; aduanas.
capacidades dinámicas en el desarrollo del desempeño organizacional de las empresas agroindustriales de la provincia de El Oro
Authors: Troya-Vera Joselyn , Giler-Yupa Diana , Romero-Black Wilton , Mora-Sanchez Norman
Published: September 2022

La presente investigación busca de pensar que situación actual de las capacidades dinámicas en el desarrollo del desempeño organizacional de las empresas agroindustriales de la provincia de El Oro, de tal manera que se reconozcan la fortaleza y debilidades empresarial, con la finalidad de mejorar los procesos, métodos, herramientas y estrategias utilizadas por dichas organizaciones. El objetivo general es: determinar las capacidades dinámicas de las empresas agroindustriales en la provincia de El Oro, cuyo propósito se enfoca en el conocimiento de la situación actual de las capacidades dinámicas de las empresas agroindustriales de El Oro y la interpretación de la información recolectada. La metodología empleada se enfoca en el tipo de investigación descriptivo, con enfoque cualitativo y una muestra no probabilístico; como técnicas de recolección de datos se empleó una encuesta con formato de escala de likert, una entrevista y un Focus Group, cuyos resultados exteriorizaron que en la mayoría de las empresas agroindustriales de la provincia de El Oro se mantienen capacidades dinámicas óptimas, guiadas por capacitaciones constantes y el uso de herramientas adecuadas para el funcionamiento eficaz de los procesos. Concluyendo, que los factores negativos se encuentran en menor cantidad, sobre todo aquellos que son manipulados por el entorno exterior.
Palabras Claves:
Empresas agroindustriales, capacidades dinámicas, desempeño organizacional
A classic surplus-shortage of nurses in Indonesia
Authors: Gunawan Joko , Aungsuroch Yupin
Published: September 2022

This article aims to describe the current context of the surplus-shortage of nurses in Indonesia. Some concerns are raised, and recommendations are provided. The data provided in this paper may be helpful to policymakers, human resource managers, hospital managers, and nurse managers in solving the problems.
Nurses’ recruitment and selection: Lessons learned from the COVID-19 pandemic in Indonesia
Authors: Nazliansyah Nazliansyah , Gunawan Joko
Published: September 2022

The purpose of this paper is to describe the current state of the recruitment and selection of nurses in Indonesia as a reflection on the pandemic. This article may be useful for evaluating the effectiveness of the human resource management system in Indonesia.  However, nurses are heroes to be appreciated.
Nursing career ladder system in Indonesia: The hospital context
Authors: Gunawan Joko , Juanamasta I Gede
Published: September 2022

It is no doubt that being a nurse is very promising in the future, considering the existence and importance of nurses during the COVID-19 pandemic. Therefore, the government is asked to invest more seriously in the advancement of nurses, both in terms of competence and their professional career path. This article focuses on an overview of the nursing career ladder system and how far it is applied in the context of hospitals in Indonesia. Barriers and challenges are also presented for future recommendations.
STORYTELLING OF SPOOF TEXT FOR THE ELEVENTH GRADERS: ADVANCING THE BEGINNER SPEAKER
Authors: Ittaqi Dafir Mustofa , Indah Rohmani Nur
Published: September 2022

Speaking is one of the problematic aspects of language learning for the teacher to help them more actively engaged during the teaching-learning process. However, studies show that choosing the right teaching strategy and media can overcome student’s speaking difficulties. One of the strategies chosen in this research is teaching spoof text storytelling. This study aims to describe how the storytelling of spoof text can improve students’ achievement in speaking skill for eleventh-graders. The method used is classroom action research following Kemmis & Taggart’s model with the procedures of planning, acting, observing, and reflecting. The study was carried out in two cycles. Each cycle consisted of two meetings, and the result of the study showed significant improvement of students’ active participation in classroom and fluency in speech. Most of the students obtained higher scores at the end of the research cycle. It proves that the use of storytelling of spoof text can improve students’s speaking skill. The finding of this study implies the need of English teacher's creativity to support the student's speaking skill by using interesting learning materials and strategies
BENCANA KEKERINGAN MEMBUAT GANGGUAN MENTAL TOKOH KITA DALAM NOVEL KERING KARYA IWAN SIMATUPANG
Authors: Haryadi Haryadi , Gunawan Gunawan , Supriatini Supriatini , Listini Listini , Parwanti Sri
Published: September 2022

Tujuan penelitian ini  adalah untuk mendeskripsikan akibat bencana kekeringan yang terjadi di daerah transmigrasi. Hal ini membuat Tokoh Kita mengalami gangguan mental. Hal-hal yang dideskripsikan adalah bentuk, penyebab, akibat, dan solusi. Metode penelitian ini adalah kualitatif dengan menggunakan metode analisis isi. Desain penelitian berupa pengajuan pertanyaan, pengumpulan data, dan penginterpretasian data. Hasil penelitian  adalah sebagai berikut. (1) Bentuk gangguan mental yang dialami Tokoh Kita, yaitu depresi, halunisasi, dan skizofrenia. (2) Penyebab gangguan mental Tokoh Kita yaitu jengkel, putus asa, tinggal sendirian di perkampungan transmigrasi, dan menggali sumur sendirian. (3) Akibat gangguan mental Tokoh Kita, yaitu menyapa dengan siapa saja yang ditemui di jalan, halunisasi, dan dua kali masuk rumah sakit jiwa. (4) Solusi yang dilakukan Tokoh Kita untuk mengatasi gangguan mental, yaitu merasa menyesal dengan perbuatan yang menyimpang selama ini, meminta maaf kepada orang-orang yang pernah disakiti, bertobat, dan membangun kota.
Kesiapsiagaan Perawat dalam Menghadapi Bencana: Literature Review
Authors: Ihsan Farly , Kosasih Cecep Eli , Emaliyawati Etika
Published: September 2022

Kesiapsiagaan perawat menghadapi bencana penting untuk menentukan tingkat keberhasilan penanggulangan bencana. Perawat mempunyai peran penting memberikan tindakan keperawatan pada fase mitigasi bencana, preparedness, response, recovery dan rehabilitation. Tujuan dari literature review ini untuk mengidentifikasi kesiapsiagaan perawat dalam menghadapi bencana. Pengumpulan data dengan cara mencari artikel tahun publikasi 2010-2020 menggunakan Pubmed, Proquest, Ebsco dan Google Scholar dengan kata kunci nurse, disaster, preparedness, disaster Preparedness, dan disaster management. Kriteria Inklusi yaitu abstrak dan full text, tipe pencarian di data base dengan journal article, desain studi cross sectional, diterbitkan dalam bahasa Indonesia dan inggris, artikel diterbitkan pada tahun 2010 – 2020 dan artikel yang membahas kesiapsiagaan perawat menghadapi bencana. Pencarian artikel menggunakan PRISMA flow Diagram menghasilkan 1859 artikel tetapi hanya 12 artikel yang masuk ke dalam tinjauan analisis artikel. 12 artikel yang dianalisis menunjukkan bahwa mayoritas perawat tidak siap dalam menghadapi bencana dengan rentang 46,5% - 97,5%. Namun demikian, sebanyak 69% perawat berminat untuk mengikuti pelatihan kebencanaan untuk kesiapsiagaan dalam perlindungan diri. Hasil review dari penelitian ini menyimpulkan bahwa perawat kurang optimal dalam menghadapi bencana, sehingga setiap instansi harus mendorong diadakannya pelatihan kesiapsiagaan perawat dalam menghadapi bencana.
Pengaruh Edukasi Bantuan Hidup Dasar dengan Media Audio Visual terhadap Pengetahuan Pengawas Kolam Renang di Kabupaten Purbalingga
Authors: Nurjanah Dina Siti , Suparti Sri
Published: September 2022

Tenggelam merupakan kondisi terbenamnya tubuh kedalam air yang mengakibatkan gangguan sistem pernapasan sehingga berakibat fatal dan berujung pada kematian. Pemberian Bantuan Hidup Dasar (BHD) pada kasus tenggelam sangat penting untuk kelangsungan hidup korban. Kejadian tenggelam dapat ditemukan di kawasan wisata kolam renang, sehingga penting sekali memberikan edukasi guna meningkatkan pengetahuan BHD pada pengawas kolam renang. Pengetahuan mengenai BHD bisa didapatkan melalui berbagai macam metode dengan menggunakan kemajuan teknologi seperti media audio visual. Penelitian ini bertujuan untuk memahami pengaruh edukasi BHD dengan media audio visual terhadap pengetahuan pengawas kolam renang di Kabupaten Purbalingga. Penelitian ini menggunakan metode kuantitatif dengan desain pre eksperimental one group pre test – post test design. Populasi dalam penelitian ini adalah seluruh pengawas kolam renang Tirto Asri Walik dan Obyek Wisata Air Bojongsari. Jumlah sampel 31 responden dengan teknik total sampling. Instrumen penelitian menggunakan lembar kuesioner dan analisa data menggunakan uji wilcoxon. Hasil penelitian menunjukkan pengetahuan rata-rata sebelum diberikan edukasi 73,23; setelah diberikan edukasi, nilai mean meningkat menjadi 82,58 dengan p value <0,001. Edukasi BHD dengan media audio visual meningkatkan pengetahuan pengawas kolam renang di Kabupaten Purbalingga.
Hubungan Pengetahuan dengan Upaya Penerapan Keselamatan dan Kesehatan Kerja (K3) pada Karyawan PT Sambas Wijaya
Authors: Prasetya Catur Bayu , Ramdani Meida Laely
Published: September 2022

Penerapan keselamatan dan kesehatan kerja (K3) sangat penting bagi keselamatan karyawan sehingga upaya penerapan K3 terhadap karyawan dibutuhkan. Pengetahuan tentang K3 diperlukan dalam setiap perusahaan untuk meminimalisir terjadinya kecelakaan kerja akibat kelalaian karyawan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dengan upaya penerapan keselamatan dan kesehatan kerja (K3) pada karyawan PT Sambas Wijaya. Jenis penelitian ini adalah kuantitatif dengan teknik pendekatan cross sectional. Sampel sebanyak 65 responden karyawan PT Sambas Wijaya Purbalingga dimana pengambilan sampel menggunakan teknik purposive sampling. Sebagian besar responden berusia 33-37 tahun. Tingkat pendidikan responden sebagian besar tamatan SMA mencapai 70,8% dan sebagian besar masa kerja responden lebih dari 5 tahun mencapai 75% yang terdiri dari empat bidang pekerjaan yaitu Crusher, Asphalt Mixing Plant, Maintanance, dan Logistic. Tingkat pengetahuan tentang K3 pada responden sebagian besar sudah tinggi yaitu mencapai 44 orang (67,7%). Penerapan K3 yang dilakukan responden sebagian besar sudah baik sebesar 39 orang (60%). Analisis bivariat mengunakan uji chi-square menunjukkan bahwa ada hubungan yang signifikan antara tingkat pengetahuan K3 dengan upaya penerapan K3 pada karyawan PT Sambas Wijaya dengan nilai r hitung 12,766  > r tabel 5,9915 dan nilai p value 0,002 < α 0,05.
Initiation of Body Segment Reorientation in Steering is not Altered While Dual Tasking
Authors: Pradeep Ambati Venkata Naga , Escalante Guillermo , Saucedo Fabricio , Reed-Jones Rebecca , Garcia-Guevara Ivy
Published: September 2022

Changing the direction of locomotion, often referred to as “steering”, is an integral component of human locomotion. This study sought to investigate the role of cognition in steering using a dual task paradigm in healthy young and healthy older adults. Twenty-five healthy young adults and nineteen healthy older adults completed a 900 walking turn at a comfortable pace under single and dual task conditions. Dependent variables included the time taken to turn and the turn onset of the head, trunk, and pelvis segments. Results indicate dual tasking increases the time taken to turn but does not alter the sequence of initiation of segment reorientation into the turn. The effects of aging on these behaviors were minimal. Most notable was that the older adults did not slow their turns as much as the young adults did during dual tasking. These results suggest that initiation of segment reorientation is independent of cognitive influence but that increased cognitive load is considered when planning movement time.
Barnens tid och framtid : En studie av den svenska asylbyråkratin efter 2015
Authors: Lindberg Anna , Lundberg Anna , Muftee Mehek
Published: September 2022

Syftet med denna studie är att analysera asylbyråkratins tidssyn, tidsanvändning och tidsstyrning samt peka på konsekvenserna av detta för skyddssökande familjer och rätten till asyl: Hur används tid och vilka perspektiv på tid tonar fram i asylprövningen på Migrationsverket, den myndighet som genomför svensk asylpolitik? Hur fördelas makten över tiden, mellan myndigheter och domstolar som fattar beslut i asylärenden, å ena sidan, och de skyddssökande familjerna vars framtid står på spel, å den andra? Vilka rättigheter följer med tiden? Vilken betydelse får tiden som barnen och deras föräldrar fått vänta för utfallet i ärendena? Hur samspelar tidsanvändningen och dess konsekvenser med barns rättigheter, nu när FN:s barnkonvention blivit svensk lag?
Challenges of intracellular visualization using virtual and augmented reality
Authors: Valades-Cruz Cesar Augusto , Leconte Ludovic , Fouche Gwendal , Blanc Thomas , Van Hille Nathan , Fournier Kevin , Laurent Tao , Gallean Benjamin , Deslandes Francois , Hajj Bassam , Faure Emmanuel , Argelaguet Ferran , Trubuil Alain , Isenberg Tobias , Masson Jean-Baptiste , Salamero Jean , Kervrann Charles
Published: September 2022

Microscopy image observation is commonly performed on 2D screens, which limits human capacities to grasp volumetric, complex, and discrete biological dynamics. With the massive production of multidimensional images (3D + time, multi-channels) and derived images (e.g., restored images, segmentation maps, and object tracks), scientists need appropriate visualization and navigation methods to better apprehend the amount of information in their content. New modes of visualization have emerged, including virtual reality (VR)/augmented reality (AR) approaches which should allow more accurate analysis and exploration of large time series of volumetric images, such as those produced by the latest 3D + time fluorescence microscopy. They include integrated algorithms that allow researchers to interactively explore complex spatiotemporal objects at the scale of single cells or multicellular systems, almost in a real time manner. In practice, however, immersion of the user within 3D + time microscopy data represents both a paradigm shift in human-image interaction and an acculturation challenge, for the concerned community. To promote a broader adoption of these approaches by biologists, further dialogue is needed between the bioimaging community and the VR&AR developers.
Ultrasound and laser-promoted dual-gas nano-generator for combined photothermal and immune tumor therapy
Authors: Li XinYu , Gao Yong , Liu XinZheng , Hu XiaoQian , Li YunMeng , Sun JunXi , Wang PingYu , Wu Hongkai , Kim HaeWon , Ramalingam Murugan , Xie ShuYang , Wang RanRan
Published: September 2022

The combination of photothermal therapy (PTT) and immune tumor therapy has emerged as a promising avenue for cancer treatment. However, the insufficient immune response caused by inefficient immunogenic cell death (ICD) inducers and thermal resistance, immunosuppression, and immune escape resulting from the hypoxic microenvironment of solid tumors severely limit its efficacy. Herein, we report an ultrasound and laser-promoted dual-gas nano-generator (calcium carbonate-polydopamine-manganese oxide nanoparticles, CPM NPs) for enhanced photothermal/immune tumor therapy through reprogramming tumor hypoxic microenvironment. In this system, CPM NPs undergo reactive decomposition in a moderately acidic tumor, resulting in the generation of calcium, manganese ions, carbon dioxide (CO2), and oxygen (O2). Calcium and manganese ions act as adjuvants that trigger an immune response. The cancer cell membrane rupture caused by sudden burst of bubbles (CO2 and O2) under ultrasound stimulation and the photothermal properties of PDA also contributed to the ICD effect. The generation of O2 alleviates tumor hypoxia and thus reduces hypoxia-induced heat resistance and immunosuppressive effects, thereby improving the therapeutic efficacy of combination PTT and immune therapy. The present study provides a novel approach for the fabrication of a safe and effective tumor treatment platform for future clinical applications.
Modified nanofat grafting: Stromal vascular fraction simple and efficient mechanical isolation technique and perspectives in clinical recellularization applications
Authors: Girard Paul , Dulong Joelle , Duisit Jerome , Mocquard Camille , Le Gallou Simon , Chaput Benoit , Lupon Elise , Watier Eric , Varin Audrey , Tarte Karin , Bertheuil Nicolas
Published: September 2022

Background: Nanofat grafting (NG) is a simple and cost-effective method of lipoaspirates with inter-syringe passages, to produce stromal vascular fraction (SVF) and isolate adipose-derived stem cells (ASCs). This represents a tremendous interest in the future clinical needs of tissue engineering. In this study, we optimized the NG technique to increase the yield of ASC extractions.

Methods: We analyzed three groups of SVF obtained by 20, 30, and 40 inter-syringe passages. The control group was an SVF obtained by enzymatic digestion with Celase. We studied their cell composition by flow cytometry, observed their architecture by confocal microscopy, and observed immunomodulatory properties of the ASCs from each of the SVFs by measuring inflammatory markers of macrophages obtained by an ASC monocyte co-culture.

Results: We have established the first cell mapping of the stromal vascular fraction of adipose tissue. The results showed that SVF obtained by 20 inter-syringe passages contains more statistically significant total cells, more cells expressing the ASC phenotype, more endothelial cells, and produces more CFU-F than the SVF obtained by 30 and 40 passages and by enzymatic digestion. Confocal microscopy showed the presence of residual adipocytes in SVF obtained by inter-syringe passages but not by enzymatic digestion. The functional study indicates an orientation toward a more anti-inflammatory profile and homogenization of their immunomodulatory properties.

Conclusion: This study places mechanically dissociated SVF in the center of approaches to easily extract ASCs and a wide variety and number of other progenitor cells, immediately available in a clinical setting to provide both the amount and quality of cells required for decellularized tissues.
Engineering constructed of high selectivity dexamethasone aptamer based on truncation and mutation technology
Authors: Qin Yadi , Qin Yanan , Bubiajiaer Hayilati , Chen Fengxia , Yao Jun , Zhang Minwei
Published: September 2022

Various biosensors based on aptamers are currently the most popular rapid detection approaches, but the performance of these sensors is closely related to the affinity of aptamers. In this work, a strategy for constructed high-affinity aptamer was proposed. By truncating the bases flanking the 59 nt dexamethasones (DEX) original aptamer sequence to improve the sensitivity of the aptamer to DEX, and then base mutation was introduced to further improve the sensitivity and selectivity of aptamers. Finally, the 33 nt aptamer Apt-M13 with G-quadruplex structures was obtained. The dissociation constant (Kd) was determined to be 200 nM by Graphene oxide (GO)-based fluorometry. As-prepared Apt-M13 was used for a label-free colorimetric aptamer sensor based on gold nanoparticles, the LOD was 3.2-fold lower than the original aptamer described in previous works. The anti-interference ability of DEX analogs is also further improved. It indicates that truncation technology effectively improves the specificity of the aptamer to DEX in this work, and the introduction of mutation further improves the affinity and selectivity of the aptamer to DEX. Therefore, the proposed aptamer optimization method is also expected to become a general strategy for various aptamer sequences.
TAK1 inhibition increases proliferation and differentiation of chick retinal cells
Authors: Carrillo Casandra , Ravi Vagisha , Tiwari Sarika , Chernoff Ellen A. , Belecky-Adams Teri L.
Published: September 2022

The factors necessary for the differentiation of cell types within the retina are incompletely understood. The transforming growth factor beta (TGF-β) superfamily, including TGF-β1 and 2, the bone morphogenetic proteins, and the activins have all been implicated in differentiation; however, the mechanisms by which these factors affect differentiation are only partially understood. The studies herein focus on a potential role for transforming growth factor β-activated kinase 1 (TAK1), a hub kinase that lies at the intersection of multiple signaling pathways, in the differentiation of cell types within the chick retina. Previous studies have focused predominantly on the role this kinase plays in the inflammation process and axonal growth. TAK1 is downstream of multiple signaling pathways that are critical to development of the central nervous system, including transforming growth factor β (TGFβ), bone morphogenetic proteins (BMPs), and activins. The present study indicates that activated TAK1 is found throughout the developing retina; however, it is localized at higher levels in dividing and differentiating cells. Further, ex ovo retinal studies using TAK1 inhibitor 5Z-7-oxozeaenol increased both progenitor and differentiating cell populations, accompanied by a substantial increase in proliferation and a smaller increase in cell death. These results indicate a unique role for TAK1 in differentiating and proliferating retinal cells.
Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions
Authors: Soundararajan Avinash , Wang Ting , Sundararajan Rekha , Wijeratne Aruna , Mosley Amber , Harvey Faith Christine , Bhattacharya Sanjoy , Pattabiraman Padmanabhan Paranji
Published: September 2022

Trabecular meshwork (TM) tissue is subjected to constant mechanical stress due to the ocular pulse created by the cardiac cycle. This brings about alterations in the membrane lipids and associated cell–cell adhesion and cell–extracellular matrix (ECM) interactions, triggering intracellular signaling responses to counter mechanical insults. A loss of such response can lead to elevated intraocular pressure (IOP), a major risk factor for primary open-angle glaucoma. This study is aimed to understand the changes in signaling responses by TM subjected to mechanical stretch. We utilized multiomics to perform an unbiased mRNA sequencing to identify changes in transcripts, mass spectrometry- (MS-) based quantitative proteomics for protein changes, and multiple reaction monitoring (MRM) profiling-based MS and high-performance liquid chromatography (HPLC-) based MS to characterize the lipid changes. We performed pathway analysis to obtain an integrated map of TM response to mechanical stretch. The human TM cells subjected to mechanical stretch demonstrated an upregulation of protein quality control, oxidative damage response, pro-autophagic signal, induction of anti-apoptotic, and survival signaling. We propose that mechanical stretch-induced lipid signaling via increased ceramide and sphingomyelin potentially contributes to increased TM stiffness through actin-cytoskeleton reorganization and profibrotic response. Interestingly, increased phospholipids and diacylglycerol due to mechanical stretch potentially enable cell membrane remodeling and changes in signaling pathways to alter cellular contractility. Overall, we propose the mechanistic interplay of macromolecules to bring about a concerted cellular response in TM cells to achieve mechanotransduction and IOP regulation when TM cells undergo mechanical stretch.
Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury
Authors: Su Jing , Bian Chenbin , Zheng Zhuangzhuang , Wang Huanhuan , Meng Lingbin , Xin Ying , Jiang Xin
Published: September 2022

Ferroptosis is a kind of oxidative stress-dependent cell death characterized by iron accumulation and lipid peroxidation. It can work in conjunction with radiation to increase reactive oxygen species (ROS) generation and disrupt the antioxidant system, suppressing tumor progression. Radiation can induce ferroptosis by creating ROS, depleting glutathione, activating genes linked to DNA damage and increasing the expression of acyl-CoA synthetase long-chain family member 4 (ACSL4) in tumor cells. Furthermore, ferroptosis can enhance radiosensitivity by causing an iron overload, destruction of the antioxidant system, and lipid peroxidation. Radiation can also cause ferroptosis in normal cells, resulting in radiation injury. The role of ferroptosis in radiation-induced lung, intestinal, skin, and hematological injuries have been studied. In this review, we summarize the potential mechanisms linking ferroptosis, oxidative stress and radiation; analyze the function of ferroptosis in tumor suppression and radiation injury; and discuss the potential of ferroptosis regulation to improve radiotherapy efficacy and reduce adverse effects.
Neddylation pattern indicates tumor microenvironment characterization and predicts prognosis in lung adenocarcinoma
Authors: Cui Yuan , Chen Zhike , Pan Bin , Chen Tong , Ding Hao , Li Qifan , Wan Li , Luo Gaomeng , Sun Lang , Ding Cheng , Yang Jian , Tong Xin , Zhao Jun
Published: September 2022

Background: Lung adenocarcinoma (LUAD) is the most common type of lung cancer with a complex tumor microenvironment. Neddylation, as a type of post-translational modification, plays a vital role in the development of LUAD. To date, no study has explored the potential of neddylation-associated genes for LUAD classification, prognosis prediction, and treatment response evaluation.

Methods: Seventy-six neddylation-associated prognostic genes were identified by Univariate Cox analysis. Patients with LUAD were classified into two patterns based on unsupervised consensus clustering analysis. In addition, a 10-gene prognostic signature was constructed using LASSO-Cox and a multivariate stepwise regression approach.

Results: Substantial differences were observed between the two patterns of LUAD in terms of prognosis. Compared with neddylation cluster2, neddylation cluster1 exhibited low levels of immune infiltration that promote tumor progression. Additionally, the neddylation-related risk score correlated with clinical parameters and it can be a good predictor of patient outcomes, gene mutation levels, and chemotherapeutic responses.

Conclusion: Neddylation patterns can distinguish tumor microenvironment and prognosis in patients with LUAD. Prognostic signatures based on neddylation-associated genes can predict patient outcomes and guide personalized treatment.