bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF CABOZANTINIB & NIVOLUMAB IN COMBINED PHARMACEUTICAL DOSAGE FORMS BY RP-HPLC
Authors:   Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, Telangana, India., Rama Rao Tadikonda , Bharath Jadhav ,   Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, Telangana, India.
Published: October 2024

A simple, accurate and precise HPLC method for simultaneous determination of Cabozantinib and Nivolumab in pure and tablet dosage form has been developed. HPLC of Waters (Model: Alliance 2695) with Phenomenax Luna C18(4.6 mm Ã— 250 mm, 5 Âµm) column was used for chromatographic separation. Mobile phase consists of Methanol: Water (65:35% v/v) and flow rate adjusted was 1 ml/min. Wavelength selected for detection was 220 nm and injection volume was 10 Âµl. The method has been validated for linearity, accuracy, and precision. The linearity of Cabozantinib and Nivolumab were in the range of 30 Î¼g/ml respectively. The developed HPLC method offers several advantages such as rapidity, usage of simple mobile phase and easy sample preparation steps. Further, improved sensitivity makes it specific and reliable for its intended use. Hence, this method can be applied for the analysis of pure drug and pharmaceutical dosage forms. From the present study it can be concluded that the proposed method is simple, sensitive, precise, specific, accurate and reproducible. Results of validation parameters demonstrated that the analytical procedure is suitable for its intended purpose and meets the criteria defined in ICH.
VOMITING AND EPIGASTRALGIA: IS IT BOUVERET SYNDROME? ABOUT A CASE
Authors:   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., Salih Abdesslam , Lahlali Maria ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., Lamine Asmae ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., Lahmidani Nada ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., El Mekkaoui Amine ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., Elyousfi Mounia ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., Benajah Dafr-Allah ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., El Abkari Mohammed ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., Adil Ibrahimi Sidi ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez., Abid Hakima ,   Gastroenterology Department, Hassan II University Hospital Center of Fez Faculty of Medicine of Pharmacy and Dentistry of Fez, Sidi Mohammed Ben Abdallah University Fez.
Published: October 2024

Bouverets syndrome is defined by a pyloroduodenal obstruction due to a blockage of a gallstone that has migrated through a cholecystoduodenal fistula. It is a rare entity from which the case of a 50-year-old patient presenting with vomiting with epigastralgia is reported, in whom abdominal ultrasound objectified an aerobic cholecystitis with cholecysto-duodenal fistula CT confirmed the ultrasound data and showed an enclosed gallstone at the duodenal level as well as oesogastroduodenalfibroscopy. The laparotomy objectified: a gallbladder attached to the genus superius with a stone measuring 4 cm which migrated at the level of the Treitz angle, the gesture consisted in the extraction of the stone and retrograde cholecystectomy as well as the resection of the fistulous path.
The effect of weather on stock market returns: Evidence from African stock markets
Authors: Alloul Fouzia , Mehdi Ferrouhi El
Published: October 2024

Increasing market volatility and the profound impacts of climate change require a comprehensive understanding of how weather affects stock market performance. This paper aims to investigate the effect of eight weather conditions (clear sky, precipitation, pressure, temperature, relative humidity, specific humidity, wind direction, and wind speed) on the returns of major African stock markets (Botswana, Cote d’Ivoire, Kenya, Mauritius, Morocco, Namibia, Nigeria, Rwanda, South Africa, Tanzania, Tunisia, Uganda and Zambia) over the period from January 2, 1998 to December 30, 2023. Using daily data and a GJR-GARCH (1,1) model with an AR process, the findings reveal that weather conditions influence all African stock markets. Specifically, the markets are categorized according to their sensitivity to weather conditions into three groups: highly affected (5-7 coefficients with 0.001≤ p <0.05), moderately affected (3-4 coefficients with 0.001≤ p <0.05), and slightly affected (1-2 coefficients with 0.001≤ p <0.05). Mauritius and Uganda emerge as the most weather-sensitive countries, with significant impacts (0.001≤ p <0.05) for seven of the eight weather conditions studied. Understanding the relationship between weather conditions and African stock markets enables investors to adjust their strategies and better manage their portfolios to optimize return opportunities. Ultimately, this study provides essential insights for investors, portfolio managers, and financial decision-makers, aiding them in better assessing the risks and opportunities associated with weather conditions in African stock markets, thereby enhancing their decision-making and investment management.
Relationship between corporate governance and intellectual capital: Evidence from Jordan
Authors: Fawzi Shubita Mohammad , Dheyauldeen Salahaldin Ahmed , Habis Alrawashedh Nahed , Ahmad Alqam Mohammad
Published: October 2024

The objective of this study is to examine the relationship between corporate governance and intellectual capital within Jordanian manufacturing firms. This study used a sample of Jordanian manufacturing firms and applied regression analysis to test the effects of board size, executive director duality, percentage of independent directors, and ownership concentration on intelligence capital performance. Thus, 64 Jordanian listed manufacturing firms represent the study sample for the study period (2014–2022). The study employs advanced statistical methods to evaluate how these governance mechanisms affect intellectual capital, including human, structural, and relational capital. The study results indicate that the board size and CEO duality had no significant impact on intellectual capital performance. A positive significant determinant is the firm performance measured by earnings per share with a coefficient estimate of 6.331 at p-value <0.0. The significant positive effect of firm performance on intellectual capital performance indicates that financial health is an important driver of intellectual capital utilization. Good firms are likely to have more resources to invest in human capital, technology, and innovation, which are necessary components of intellectual capital. Future research should continue to explore these dynamics across different contexts to inform more effective governance and management practices.
DIAGNÓSTICO DOS SERVIÇOS PRESTADOS PELA MECÂNICA CANAÃ
Authors: Oliveira Patrícia Fonseca , Santos Marcos Ferreira
Published: October 2024

O ambiente de serviços está cada vez mais tomando espaço na economia. O setor automobilístico em especial tem sido enfatizado em estudos de aprimoramento do processo de serviços, uma vez que os consumidores tornaram-se exigentes, devido às influências do meio de comunicação e a conscientização da necessidade de melhoria dos serviços. Conquistar e manter clientes têm sido o foco das empresas que desejam manter-se no mercado, almejando cada vez mais aumentar o índice de satisfação de seus consumidores, com o intuito de torná-los fiéis e assim garantir a sustentabilidade da empresa, gerada pelo índice de vendas. Com a concorrência isso torna-se mais difícil, é necessário buscar alternativas para se diferenciar e conquistar o poder de compra do consumidor. Em virtude disso, realizou-se um estudo para diagnosticar os serviços prestados pela Mecânica Canaã. Primeiramente descreve-se o problema de pesquisa, que busca diagnosticar os serviços prestados pela Mecânica Canaã, objeto do estudo. Posteriormente, são definidos os objetivos do presente estudo que contribuíram para responder ao problema de pesquisa. O embasamento teórico explica diversos aspectos do marketing de serviços, e como o mesmo contribui para melhoria na prestação do serviço. Logo após são analisados os meios pelos quais foi realizada a pesquisa em campo, os métodos utilizados, seguindo a análise dos resultados, onde são demonstrados os resultados colhidos dos questionários aplicados aos clientes, bem como a entrevista feita aos administradores do estabelecimento. As propostas de melhoria para os gargalos encontrados no diagnóstico são apresentadas nas considerações finais, com alternativas para minimizar o impacto dos pontos negativos no processo de serviço.
O EXÉRCITO NA HISTÓRIA POLÍTICA DO BRASIL: CONSIDERAÇÕES ACERCA DA RACIONALIDADE MILITAR COMO ELEMENTO MOTIVADOR DO GOLPE DE 1964
Authors: Oliveira Ueber José de
Published: October 2024

Analisa-se, neste artigo, o papel do exército na história política do Brasil, tendo como base a racionalidade militar como elemento motivador do golpe de 1964,  este período é um dos mais importantes episódios da história política brasileira enquanto um país independente. E o que mais chama a atenção é o fato de neles despontarem como protagonistas do processo as Forças Armas, evidenciando um componente estrutural decisivo da política brasileira em sua trajetória, qual seja: o poder militar Segundo Maranhão (2004), no Brasil, "[...] o Exército [em especial], principalmente nos seus escalões de chefia, é um importante centro de ação e decisão política interna [..]".
DIETA CARIOGÊNICA EM PRIMATAS NEOTROPICAIS CATIVOS: IMPACTOS NA SAÚDE ORAL E ESTRATÉGIAS NUTRICIONAIS PREVENTIVAS NA MEDICINA VETERINÁRIA
Authors: De Souza Marcos Vinicius , Gomes Botelho Nubia Estéfane , Maria Larissa Bitencourt Vidal
Published: October 2024

Este estudo investigou os efeitos de dietas cariogênicas em primatas neotropicais cativos, com ênfase nos impactos sobre a saúde oral e suas implicações na Medicina Veterinária. A pesquisa analisou primatas sul-americanos, revelando uma alta prevalência de cáries e doenças periodontais associadas ao consumo frequente de alimentos ricos em açúcares simples. Além da avaliação clínica, o estudo discutiu estratégias nutricionais preventivas, como a redução de frutas e açúcares refinados na dieta, e a introdução de alimentos fibrosos e rações comerciais adequadas, que estimulam a mastigação e promovem a limpeza natural dos dentes. Concluiu-se que uma dieta balanceada, adaptada às necessidades biológicas dos primatas, é fundamental para prevenir doenças orais e garantir o bem-estar desses animais em cativeiro.
ESPOROTRICOSE EM GATOS: UMA ANÁLISE DOS IMPACTOS NA COMUNIDADE DE MANHUAÇU-MG
Authors: Maria Larissa Bitencourt Vidal  , Amanda Venturin da Silva Neto  , Ana Alicia Euzébio de Melo  , Cauant Luiz Dutra Soares  , Luiza Almeida Andrade  , Marcelle Avelino de Oliveira  , Matheus Ker Lopes  , Marcos Vinícius de Souza
Published: October 2024

A esporotricose, causada pelo fungo Sporothrix schenckii, é uma zoonose de grande relevância para a saúde pública, afetando principalmente gatos e humanos. Este estudo visa analisar a prevalência e o conhecimento sobre a doença na comunidade de Manhuaçu-MG. Dados de atendimentos da Clínica Municipal Veterinária foram coletados, evidenciando o aumento dos casos de esporotricose felina e a necessidade de maior conscientização pública. O estudo também explorou os impactos sociais e as opções de tratamento, com destaque para a eutanásia como escolha frequente em gatos com quadro clínico grave.
Identifying Green Bonds Impact on Company Reputation and Risk
Authors: Estiningrum Widya , Husodo Zaäfri Ananto
Published: October 2024

In recent years, there has been a growing awareness of the severity of climate-related risks, prompting a global imperative for environmental preservation. As a result, companies are now vital contributors to sustainability efforts, requiring them to integrate environmental, social, and governance factors into their investment and financing decisions. This paper aims to provide other researchers and stakeholders with some new ideas and a clear understanding of the important research trends in studies about how certain methods linked to issuing green bonds can impact a company's reputation and associated risk. By employing a Systematic Literature Review (SLR) and content analysis of 45 articles, the research takes a corporate-centric perspective. The findings of this paper reveal a gap in the literature concerning the direct influence of green bond issuance on company reputation and associated risks. While previous studies have explored the impact of bond issuance on various performance metrics, there remains a notable absence of detailed analysis on the relationship between green bonds and corporate reputation. By shedding light on the implications of green bond issuance for corporate reputation and risk, this research underscores the importance of integrating environmental and social considerations into strategic decision-making processes.
The Phenomenon of Brand Tribalism in Online Games Business
Authors: Lasmy Lasmy , Mehan Charu
Published: October 2024

This research aims to analyze the influence of telepresence and community factors on brand tribalism and the interest in purchasing virtual items in the online games, especially MMORPG Final Fantasy XIV in Indonesia. The empirical research was a quantitative method and data were collected from 110 respondents through online surveys in the game's Facebook and discord groups, who is the players of online game, MMORPG Final Fantasy XIV in Indonesia. The research model was tested using statistical software, SPSS. Results indicate that telepresence and community factors significantly impact brand tribalism and interest in purchasing virtual items. However, no significant relationship was found between brand tribalism and interest in virtual item purchase. This research fills the gap in previous research, regarding customer behavior in online games and the variables studied such as brand tribalism, telepresence and community factors. Similar research is rarely discussed in previous research.
Factors Inhibiting the Application of SAK-EMKM in Financial Report on MSMEs
Authors: Kartikasari Evi Dwi , Yanto Yanto , Rodhiyah Ma’rufatur , Dedyansyah Achmad Farid , Binti Zainuddin Siti Afiqah
Published: October 2024

The existence of MSMEs can be believed to reduce unemployment and crime rates in the community so MSME empowerment needs to be improved properly. Most of the residents of Sambeng Village are MSME actors, but in their MSME activities, only 3.02% have business licenses. Policies related to obtaining capital with government facilities, namely low-interest credit, require financial reports that comply with the SAK-EMKM standards. This study aims to explore more deeply the implementation of SAK-EMKM in MSME financial reports. The method is descriptive qualitative with primary data sources. A sample of 95 based on purposive sampling. The results of the study showed that many MSMEs in Sambeng District have not implemented financial reports by SAK-EMKM, namely 73% of 95 respondents. Factors that hinder MSME actors from implementing EMKM-SAK are education, literacy, and capital sources. Based on the questionnaire, MSME actors whose capital sources are loans from banks that implement EMKM-SAK and for their capital, on average do not implement.
Methodical Problems of Oratory
Authors:   Mozhaisky Military Space Academy, Steshov Anatoliy V. , Steshova Maria A. ,   St. Petersburg University of Humanities and Social Sciences
Published: October 2024

The article sets out the content of a little-studied section of rhetorical science — oratory, mastering knowledge of which can lead to the highest level of rhetorical competence, the rhetorical art. The concept of public persuasive speech and parameters of its style for perfect orators are considered. Three methodical problems of oratory that have not yet been solved are discussed. The first problem is that there is no idea about the oratory method. For all sections, kinds and types of rhetoric there can be the only one method, therefore, as a solution of this problem, it is proposed to consider the model of oratory method as identical to the model of rhetoric method. The second problem is the lack of development of the conception of rhetorical invention as the first stage of rhetorical canon. Relying on the model of oratory method and the law of rhetorical speech, the authors are presenting the solution of this problem in the form of a graphic scheme of the conception of invention as a complex of settings for thinking according to the method. The third problem of oratory is the neсessity to determine the methodology of development of persuasive speech idea. Based on the conception of rhetorical invention, the visual scheme of unified construction of ideas is developed. The authors’ visual models are applied to explain three methodical problems of oratory as the highest section of rhetoric, which constitutes the novelty of the research. So far as oratory is at crossroads of many fundamental and speech sciences, the author’s research methodology is based on the symbolic approach as one of directions of synergetics. Graphic models made it possible to develop the methodology of teaching rhetoric according to the classical canon of Aristotle’s rhetoric, what is necessary for the formation of rhetorical competence of a speaker.
On the Peculiarity of the Realization of the Event Text in Nikolai A. Markevich’s Memoirs
Authors:   V. I. Vernadsky Crimean Federal University, Kurianov Sergei О.
Published: October 2024

This article aims to show how the unpublished memoirs of Nikolai A. Markevich created mythologized representations of Russian literature of the 1810‒1820s, which formed a peculiar event epochal supertext of the literary process of that time. The introduction briefly presents the theoretical foundations of the study. In particular, it points out the peculiarities of such a form of event supertext as an epochal text. The aim of the article is to show how in Markevich’s memoirs, and especially in the part entitled “Russia, Petersburg, Literature 1817–1820”, the author’s mythology is formed, how thanks to Markevich’s skill as a memoirist an emotional perception of the epoch and historical personalities takes place. To achieve the set goal, the cultural-historical, typological, mythopoetic and structuralist methods of literary studies are used. Markevich’s “Notes”, like any memoir documents, are a unique testimony of the epoch. However, it is in these “Notes” that the author manages not only to record historical and literary events, but also to give them an emotional background, which undoubtedly creates the author’s myth about the historical time; he does not just write about the peculiarities of this or that historical personality, but often offers such an individual perspective that contradicts traditional and established assessments. The article notes that two narrative techniques — apologetics and irony — contribute to the mythologisation of the cultural and literary environment of the epoch considered by the memoirist. It is shown how the notes of Markevich conceptually in memorable constant mythologized forms reproduce the idea of the literary process of this period, that is, they create signs for the perceiving consciousness, which, having fixed in Russian literature, form the epochal event text of Russian literature of Pushkin’s epoch.
The Russian Language of Professional Communication: Linguistic and Linguodidactic Aspects
Authors:   Moscow State Linguistic University, Uskova Olga A. , Kozhevnikova Elena V. ,   Voronezh State University
Published: October 2024

The article deals with the problems of functioning and description of the Russian language in the professional sphere of communication in the real and virtual environment, the principles of description of the meta-languages of professional communication, as well as linguistic and linguodidactic foundations of teaching Russian as a foreign language in educational-professional and professional spheres. The retrospective of the formation and development of the categorical thesaurus of the linguistic representation of the professional sphere of communication allowed us to justify the definition of professional communication metalanguage adopted in this study and to formulate the principles of its description of professional communication metalanguages (thematic and situational conditioning, conceptual, intensional and style systems of the metalanguage). The conducted research has shown that metalanguages of professional communication, depending on the communication environment (real or virtual), use different linguistic means to verbalize intents, which led, firstly, to the formation of a hybrid form of spoken and written speech in the virtual environment, secondly, to the removal of restrictions on the normativity of professional speech, thirdly, to the mixing of genres of texts of spoken and written speech. According to the authors, the noted linguistic features of the current state of metalanguages of professional communication should be taken into account in the development of linguistic materials for teaching Russian language of professional communication and language of specialty, between which there are significant differences, the objectives and content of teaching Russian as a foreign language. Special attention is paid to socio-cultural competence when learning the metalanguage of professional communication and the language of specialty, expediency of using the professional-oriented and linguocultural approaches in its formation has been substantiated. Based on the analysis of the manuals textbooks, the need to create a bank of model texts and language materials for each level of Russian language of professional competence from A2 to C1 was proved.
Russian World of Asia
Authors:   M. K. Ammosov North-Eastern Federal University, Petrova Svetlana M.
Published: October 2024

Analyzing the holding of international scientific and practical conferences “Russian World of Asia”, the author examines the international activities of the Department of Russian as a Foreign Language, Faculty of Philology, North-Eastern Federal University named after M. K. Ammosov. The conference was first held on June 10–12, 2022 in Yakutsk under the auspices of the II International Forum of NEFU “Universities and Development of Geostrategic Territories of Russia”. The theme of the forum was “The Role of Universities in Ensuring Territorial Connectedness of Russia in a Changing World”. The conference discussed the current geopolitical situation in the countries of the Commonwealth of Independent States (CIS) and the Asia-Pacific Region (APR); studied the role of the Russian language as an effective mediator in international dialogue; assessed the role of the Russian language in the aspect of geopolitics and geolinguistics by the leadership of the International Association of Teachers of Russian Language and Literature (MAPRYAL), the Russian Society of Teachers of Russian Language and Literature (ROPRYAL) and employees of the Ministry of Foreign Affairs of the Russian Federation; The opinions of scientists from Russian universities and Russian specialists from Kazakhstan, Tajikistan, and Uzbekistan on the role of the Russian language were presented. The second conference “Russian World of Asia” was held on April 10–12, 2023, at the Tajik National University in Dushanbe (Republic of Tajikistan). The article reveals the content and goals of both conferences, defines the significance of each conference in promoting the Russian language in the countries of the Asia-Pacific region, Africa, and the Middle East, talks about the searches and discoveries of NEFU Russian specialists in the field of teaching Russian as a foreign language, in particular, about the introduction of an effective method of digital ecumene in the form of graphic and symbolic analysis of a literary text into the teaching structure. A conclusion is made about the importance of consolidating Russian specialists from Russian and foreign universities when creating a new generation of educational literature on the Russian language for foreigners based on cultural approaches, taking into account the mentality of students, linguistic and cultural traditions.
Integrated Exploration of Pyranocoumarin Derivatives as Synergistic Inhibitors of Dual-target for Mpro and PLpro Proteins of SARS-CoV-2 through Molecular Docking, ADMET Analysis, and Molecular Dynamics Simulation
Authors: Yamari Imane , Bouamri Lamiae El , Abchir Oussama , Bouachrine Mohammed , Kouali Mhammed El , Samadi Abdelouahid , Chtita Samir
Published: October 2024

Aims:

This study aimed to explore the potential of natural anticoagulant compounds
as synergistic inhibitors of the main protease (Mpro) and papain-like protease
(PLpro) of SARS-CoV-2 and find effective therapies against SARS-CoV-2 by investigating
the inhibitory effects of natural anticoagulant compounds on key viral proteases.

Objective:

The objectives of this study were to conduct rigorous virtual screening and
molecular docking analyses to evaluate the binding affinities and interactions of selected
anticoagulant compounds with Mpro and PLpro, to assess the pharmacokinetic and pharmacodynamic
profiles of the compounds to determine their viability for therapeutic use,
and to employ molecular dynamics simulations to understand the stability of the identified
compounds over time.

Methods:

In this study, a curated collection of natural anticoagulant compounds was conducted.
Virtual screening and molecular docking analyses were performed to assess binding
affinities and interactions with Mpro and PLpro. Furthermore, pharmacokinetic and
pharmacodynamic analyses were carried out to evaluate absorption, distribution,
metabolism, and excretion profiles. Molecular dynamics simulations were performed to
elucidate compound stability.

Results:

Natural compounds exhibiting significant inhibitory activity against Mpro and
PLpro were identified. A dual-target approach was established as a promising strategy
for attenuating viral replication and addressing coagulopathic complications associated
with SARS-CoV-2 infection.

Conclusion:

The study lays a solid foundation for experimental validation and optimization
of identified compounds, potentially leading to the development of precise treatments
for SARS-CoV-2.
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route
Authors: Chiprikar Pallavi , Mastiholimath Vinayak , Biradar Prakash , Shirkoli Nisha
Published: October 2024

Background:

Cariprazine (CPZ) is a third-generation antipsychotic medication that has been approved
for treating schizophrenia. This study aimed to develop a cariprazine-loaded nanostructured lipid carrier
(CPZ-NLCs) to prevent first-pass metabolism and improve bioavailability and site-specific delivery from
nose to the brain.

Methods:

The CPZ-NLCs were prepared using melt emulsification. The formulation was optimized using the
Box–Behnken design (BBD); where the influence of independent variables on critical quality attributes, such
as particle size and entrapment efficiency was studied.

Results:

The optimized batch (F6) had a particle size of 173.3 ± 0.6 nm and an entrapment efficiency of 96.1
± 0.57%, respectively. The in vitro release showed >96% release of CPZ from NLC within 30 min. The optimized
formulation's ex vivo studies revealed significantly increased CPZ permeability (>75%) in sheep nasal
mucosa compared to the CPZ suspension (~26%). The ciliotoxicity study of the nasal mucosa revealed that
the CPZ-NLC formulation did not affect the nasal epithelium. The intranasal administration of the formulation
achieved 76.14±6.23 μg/ml concentration in the brain which was significantly higher than the oral CPZ suspension
administration (30.46±7.24 μg/ml). The developed formulation was stable for 3 months.

Conclusion:

The study concluded that the developed CPZ-NLC could significantly improve the bioavailability
with quick delivery to the brain.
PENGARUH LEVERAGE, PROFITABILITAS DAN KEBIJAKAN DIVIDEN TERHADAP NILAI PERUSAHAAN
Authors: Reyhan el aziz Dennis , Hascaryani Tyas Danarti
Published: October 2024

The economic conditions in the era of globalization have rapidly evolved, leading to fierce competition among companies operating in various business sectors. Competition in the business world drives every company to continually improve its performance to survive and grow, making the company's value a crucial factor for investors in allocating their capital. With the existence of the capital market, entities with surplus funds can invest them, while companies can utilize these funds for investments without waiting for revenue from operational activities. The aim of this research is to determine the influence of leverage, profitability, and dividend policy on company value. The purposive sampling method is employed by selecting companies listed in the IDX30 index on the Indonesia Stock Exchange and consistently listed during the period of 2018-2020, which also consistently issue dividends annually. Data is analyzed using panel data regression. The research findings demonstrate that leverage and profitability significantly affect company value, whereas dividend policy does not significantly influence company value.
DAMPAK FAKTOR EKONOMI MAKRO DAN KINERJA KEUANGAN TERHADAP NILAI PERUSAHAAN MANUFAKTUR
Authors: Dewantara Satria , Al Muizzuddin Fazaalloh
Published: October 2024

The aim of this research is to assess the impact of macroeconomic factors, including the inflation rate and Gross Domestic Product (GDP), and performance indicators such as Return on Assets (ROA), Return on Equity (ROE), and Debt to Equity Ratio (DER), on the valuation of manufacturing companies during the period from 2018 to 2022. This study employs purposive sampling to select ten companies as samples, with specific criteria applied throughout the five-year observation period. Data is collected through non-participant observation, involving the analysis of financial reports from the chosen companies. Data analysis iscarried out using multiple linear regression analysis techniques. The research findings reveal the significant positive influence of Return on Equity (ROE) on company value, whereas other variables do not exhibit significant impacts. This underscores the critical role of Return on Equity (ROE) as a key factor affecting company valuation.
La población esclava en la jurisdicción de Ibagué y la parroquia de Chaparral. 1738-1809
Authors: Eraso Cruz Valeria
Published: October 2024

El artículo busca visibilizar la existencia de la población esclava que se ubicó en la jurisdicción de Ibagué y la parroquia de Chaparral durante los años 1738-1809 y la dinámica del mercado con relación a la oferta y demanda interna local; además, realiza una aproximación a la composición de las familias esclavas. Por otra parte, pretende dar a conocer el promedio de precios de los cautivos a razón de valores intrínsecos como procedencia, sexo, edad y algunos factores de depreciación como tachas físicas y morales. Lo anterior es resultado de la recopilación y análisis de información capturada principalmente del fondo Notarías del Archivo Histórico de Ibagué.
Global Issues and Research Trends On Science Learning Based On The Scopus Database From 2019 To 2023: A Bibliometric Analysis
Authors: Jayanti Mei Indra , Umar Umar , Syarifuddin Syarifuddin
Published: October 2024

Previous research tends to examine science learning in general, but less focus on specific sub-topics, such as inquiry-based learning, project-based learning, or STEAM approaches. The research aims to map the trend of research development related to science learning. There are 987 metadata of Scopus-indexed journal articles from 2019 to 2024. They are analyzed bibliometrically using VOSviewer software combined with the R program and Biblioshiny to find trends in science learning research. The results revealed the development of science learning research from 2019 to 2024. The highest number of Scopus-indexed in 2022 reached 228 publication articles (23.10%). Huwer J's position is the most productive author in science learning research with eight published articles. Journal of Education Sciences is the top scientific journal with 56 articles published on the topic of science learning. Michigan State University occupies the first rank as the higher education institution that publishes the most science learning research topics with 36 relevant articles. Science learning research with the topic "education computing, science classroom, engineering education, learning systems, major clinical study, science curriculum, and student motivation" is a cluster of research topics that are still new and potential to be a topic of further research in science learning.
Project-Based Learning on STEAM-Based Student's Worksheet with Ecoprint Technique: Effects on Student Scientific Reasoning and Creativity
Authors: Irdalisa Irdalisa , Paidi Paidi , Panigrahi Rashmi Ranjan , Hanum Erlia
Published: October 2024

The use of conventional worksheets will likely limit students' ability to explore themselves and their critical and analytical thinking, which can enhance their scientific reasoning and creativity. This situation demands the need for student worksheets linked to technology, art, and mathematics to adapt to the demands of the times. This study aims to determine the effect of project-based learning by analyzing student worksheets based on science, technology, engineering, arts, and mathematics (STEAM) using the eco-print technique on students’ scientific reasoning and creativity. This research is a quasi-experimental study. The research sample is 160 students of a public senior high school in Jakarta, randomly selected and grouped into control and experimental groups, each consisting of 80 students. Data on scientific reasoning were collected using a test, while student creativity was measured with a questionnaire and observation sheet. The data obtained were analyzed using a one-way analysis of covariance at the significance level of 5%. The results show that the application of project-based learning on STEAM-based student worksheets using the eco-print technique significantly affects the students’ achievement of scientific reasoning and creativity. The use of STEAM-based student worksheets with the eco-print technique serves as an innovative learning media to enhance the quality of education, as it can facilitate and increase active student engagement in collaborative projects that integrate various STEAM elements, thereby improving student competencies.
Gerencialismo na Política Educacional da Educação de Jovens e Adultos do Ensino Médio
Authors: Melo Cesar de Lima de , Araújo Jair Jonko
Published: October 2024

O presente artigo é parte de um estudo sobre o Gerencialismo na Política Educacional da Educação de Jovens e Adultos (EJA) em uma Escola Municipal, com objetivo de analisar e discutir a atuação de professores e coordenadores nas mudanças curriculares da modalidade EJA- ensino médio em uma escola municipal. Analisa-se aspectos do modelo de Estado Neoliberal, e as influências do gerencialismo, com suporte de alguns autores como Newman, Clarke e Ball. A abordagem é qualitativa, metodologia análise textual discursiva (ATD). O desenvolvimento desse estudo apresenta as percepções dos entrevistados em relação as mudanças impostas, as características do gerencialismo, austeridade, seletividade, performance na EJA. Conclui-se que os professores identificam o gerencialismo na EJA, e que o avanço do gerencialismo nas políticas educacionais tem implicações nefastas para a EJA.
Assessing the Effectiveness of an mHealth Intervention to Support Men Who Have Sex With Men Engaging in Chemsex (Budd): Single-Case and Pre-Post Experimental Design Study
Authors: Herrijgers Corinne , Verboon Peter , Florence Eric , Vandebosch Heidi , Poels Karolien , Platteau Tom
Published: October 2024

Background

This study focuses on the Budd app, a mobile health intervention designed for gay, bisexual, and other men who have sex with men who participate in chemsex. Chemsex, the use of psychoactive drugs in a sexual context, presents substantial health risks including increased HIV transmission and mental health issues. Addressing these risks requires innovative interventions tailored to the unique needs of this population.

Objective

This study aims to evaluate the effectiveness of the Budd app in promoting drug harm reduction practices among its users, focusing on knowledge, behavioral intention, risk behavior awareness, and self-efficacy.

Methods

The study used a mixed methods approach, combining a single-case experimental design and a pre-post study. A total of 10 participants from an outpatient clinic were recruited, and each attended the clinic 3 times. During the first visit, participants installed a restricted version of the Budd app, which allowed them to report daily mood and risk behavior after chemsex sessions. Phase A (baseline) lasted at least 2 weeks depending on chemsex participation. In the second visit, participants gained full access to the Budd app, initiating phase B (intervention). Phase B lasted at least 6 weeks, depending on chemsex participation, with identical data input as phase A. Participants completed pre- and postintervention surveys assessing behavioral determinants during the first and third visit.

Results

The study observed an increased knowledge about chemsex substances postintervention, with a mean percentage improvement in knowledge scores of 20.59% (SD 13.3%) among participants. Behavioral intention and self-efficacy showed mixed results, with some participants improving while others experienced a decrease. There was also a variable impact on awareness of risk behavior, with half of the participants reporting a decrease postintervention. Despite these mixed results, the app was generally well-received, with participants engaging with the app’s features an average of 50 times during the study.

Conclusions

The Budd app showed effectiveness in enhancing knowledge about chemsex substances among gay, bisexual, and other men who have sex with men. However, its impact on safe dosing behavior, behavioral intention, self-efficacy, and risk behavior awareness was inconsistent. These findings suggest that while educational interventions can increase knowledge, translating this into behavioral change is more complex and may require more participants, a longer follow-up period, and additional strategies and support mechanisms.
Integrating Patient-Generated Digital Data Into Mental Health Therapy: Mixed Methods Analysis of User Experience
Authors: Southwick Lauren , Sharma Meghana , Rai Sunny , Beidas Rinad S , Mandell David S , Asch David A , Curtis Brenda , Guntuku Sharath Chandra , Merchant Raina M
Published: October 2024

Background

Therapists and their patients increasingly discuss digital data from social media, smartphone sensors, and other online engagements within the context of psychotherapy.

Objective

We examined patients’ and mental health therapists’ experiences and perceptions following a randomized controlled trial in which they both received regular summaries of patients’ digital data (eg, dashboard) to review and discuss in session. The dashboard included data that patients consented to share from their social media posts, phone usage, and online searches.

Methods

Following the randomized controlled trial, patient (n=56) and therapist (n=44) participants completed a debriefing survey after their study completion (from December 2021 to January 2022). Participants were asked about their experience receiving a digital data dashboard in psychotherapy via closed- and open-ended questions. We calculated descriptive statistics for closed-ended questions and conducted qualitative coding via NVivo (version 10; Lumivero) and natural language processing using the machine learning tool latent Dirichlet allocation to analyze open-ended questions.

Results

Of 100 participants, nearly half (n=48, 49%) described their experience with the dashboard as “positive,” while the other half noted a “neutral” experience. Responses to the open-ended questions resulted in three thematic areas (nine subcategories): (1) dashboard experience (positive, neutral or negative, and comfortable); (2) perception of the dashboard’s impact on enhancing therapy (accountability, increased awareness over time, and objectivity); and (3) dashboard refinements (additional sources, tailored content, and privacy).

Conclusions

Patients reported that receiving their digital data helped them stay “accountable,” while therapists indicated that the dashboard helped “tailor treatment plans.” Patient and therapist surveys provided important feedback on their experience regularly discussing dashboards in psychotherapy.
Pocket de Medicina Familiar: diseño y desarrollo
Authors: Rivero-López Carlos A. , Núñez-Galván Lizbeth A. , López-Ortiz Geovani
Published: October 2024

La práctica de la medicina familiar requiere un acceso eficiente a información médica actualizada y fiable.  El libro Pocket de Medicina Familiar fue desarrollado como un recurso integral para abordar esta necesidad, proporciona a los médicos familiares y otros profesionales de la salud, pautas sobre el manejo de diversas condiciones clínicas de mayor prevalencia en el primer nivel de atención. El diseño y desarrollo de la información se desarrolló a través de 7 pasos: 1. Relevancia, 2. Accesibilidad, 3. Contenido, 4. Dinamismo, 5. Trabajo en equipo, 6. Seguimiento y 7. Evaluación. Cada capítulo del libro fue estructurado y diseñado para ser conciso y accesible en entornos clínicos, e incluyó la definición de la enfermedad, epidemiología, prevención, diagnóstico, manejo, así como aspectos biopsicosociales de relevancia en el ámbito de la medicina familiar.
Zur Rezeption Claudians: Das Wunderreich der Venus (Epithalamium de nuptiis Honori Augusti 47–98)
Authors: Simon L. Zoltán
Published: October 2024

The major influence of Claudian on Neo-Latin poetry is well known but the reception of the late antique poet is still poorly studied in its details. This paper examines four typical imitations of Claudian’s splendid description of the realm of Venus. The influence of the ekphrasis will be analysed in Boccaccio’s description of the afterlife (Buccolicum carmen), in Baptista Mantuanus’ depiction of the Garden of Eden (Parthenice), in the exotic landscapes of Lorenzo Gambara’s epic poem (De navigatione Christophori Columbi), and finally in a metapoetic elegy by Girolamo Balbi.
The effects of thermal aging on color and glossiness in UV cured coatings applied to sessile oak
Authors: Şahin Sırrı , Ayata Ümit , Esteves Bruno
Published: October 2024

Color and glossiness are two important aesthetic properties of wood flooring and wood furniture that significantly affect consumers choice. With time the coating deteriorates altering the surface properties. Understanding these changes is important for furniture industry, impacting design choices, material selection, and long-term maintenance.
The effects of thermal aging (30 °C for 30 days, 60 °C for 60 days, and 90 °C for 90 days) on color parameters (C*, L*, b*. a*, ho) and glossiness on both perpendicular (⊥) and parallel (║) directions at 20°, 60°, and 85° angles in UV-cured coatings applied on sessile oak were studied. Results show that statistically significant differences were observed in the glossiness values, as well as in C*, b*, a*, L* and ho. As the temperature and duration of the thermal aging process increased, there was a noticeable increase in the values of color parameters b*, a*, and C*, while the values of ho and L* decreased. The characteristics of the surfaces exposed to thermal aging have undergone a complete transformation.
Differentiating and Integrating ZX Diagrams with Applications to Quantum Machine Learning
Authors: Wang Quanlong , Yeung Richie , Koch Mark
Published: October 2024

ZX-calculus has proved to be a useful tool for quantum technology with a wide range of successful applications. Most of these applications are of an algebraic nature. However, other tasks that involve differentiation and integration remain unreachable with current ZX techniques. Here we elevate ZX to an analytical perspective by realising differentiation and integration entirely within the framework of ZX-calculus. We explicitly illustrate the new analytic framework of ZX-calculus by applying it in context of quantum machine learning for the analysis of barren plateaus.
Mixed-state additivity properties of magic monotones based on quantum relative entropies for single-qubit states and beyond
Authors: Rubboli Roberto , Takagi Ryuji , Tomamichel Marco
Published: October 2024

We prove that the stabilizer fidelity is multiplicative for the tensor product of an arbitrary number of single-qubit states. We also show that the relative entropy of magic becomes additive if all the single-qubit states but one belong to a symmetry axis of the stabilizer octahedron. We extend the latter results to include all the α-z Rényi relative entropy of magic. This allows us to identify a continuous set of magic monotones that are additive for single-qubit states. We also show that all the monotones mentioned above are additive for several standard two and three-qubit states subject to depolarizing noise. Finally, we obtain closed-form expressions for several states and tighter lower bounds for the overhead of probabilistic one-shot magic state distillation.