bluuebunny/crossref_metadata_2025 huggingface dataset:
Technical and Clinical Progress on Robot-Assisted Endovascular Interventions: A Review
Authors: Duan Wenke , Akinyemi Toluwanimi , Du Wenjing , Ma Jun , Chen Xingyu , Wang Fuhao , Omisore Olatunji , Luo Jingjing , Wang Hongbo , Wang Lei
Published: January 2023

Prior methods of patient care have changed in recent years due to the availability of minimally invasive surgical platforms for endovascular interventions. These platforms have demonstrated the ability to improve patients’ vascular intervention outcomes, and global morbidities and mortalities from vascular disease are decreasing. Nonetheless, there are still concerns about the long-term effects of exposing interventionalists and patients to the operational hazards in the cath lab, and the perioperative risks that patients undergo. For these reasons, robot-assisted vascular interventions were developed to provide interventionalists with the ability to perform minimally invasive procedures with improved surgical workflow. We conducted a thorough literature search and presented a review of 130 studies published within the last 20 years that focused on robot-assisted endovascular interventions and are closely related to the current gains and obstacles of vascular interventional robots published up to 2022. We assessed both the research-based prototypes and commercial products, with an emphasis on their technical characteristics and application domains. Furthermore, we outlined how the robotic platforms enhanced both surgeons’ and patients’ perioperative experiences of robot-assisted vascular interventions. Finally, we summarized our findings and proposed three key milestones that could improve the development of the next-generation vascular interventional robots.
Rational Optimization of Cathode Composites for Sulfide-Based All-Solid-State Batteries
Authors: Tron Artur , Hamid Raad , Zhang Ningxin , Beutl Alexander
Published: January 2023

All-solid-state lithium-ion batteries with argyrodite solid electrolytes have been developed to attain high conductivities of 10−3 S cm−1 in studies aiming at fast ionic conductivity of electrolytes. However, no matter how high the ionic conductivity of the electrolyte, the design of the cathode composite is often the bottleneck for high performance. Thus, optimization of the composite cathode formulation is of utmost importance. Unfortunately, many reports limit their studies to only a few parameters of the whole electrode formulation. In addition, different measurement setups and testing conditions employed for all-solid-state batteries make a comparison of results from mutually independent studies quite difficult. Therefore, a detailed investigation on different key parameters for preparation of cathodes employed in all-solid-state batteries is presented here. Employing a rational approach for optimization of composite cathodes using solid sulfide electrolytes elucidated the influence of different parameters on the cycling performance. First, powder electrodes made without binders are investigated to optimize several parameters, including the active materials’ particle morphology, the nature and amount of the conductive additive, the particle size of the solid electrolyte, as well as the active material-to-solid electrolyte ratio. Finally, cast electrodes are examined to determine the influence of a binder on cycling performance.
Hypoxia-Driven Changes in a Human Intestinal Organoid Model and the Protective Effects of Hydrolyzed Whey
Authors: de Lange Ilse H. , van Gorp Charlotte , Massy Kimberly R. I. , Kessels Lilian , Kloosterboer Nico , Bjørnshave Ann , Stampe Ostenfeld Marie , Damoiseaux Jan G. M. C. , Derikx Joep P. M. , van Gemert Wim G. , Wolfs Tim G. A. M.
Published: January 2023

Many whey proteins, peptides and protein-derived amino acids have been suggested to improve gut health through their anti-oxidant, anti-microbial, barrier-protective and immune-modulating effects. Interestingly, although the degree of hydrolysis influences peptide composition and, thereby, biological function, this important aspect is often overlooked. In the current study, we aimed to investigate the effects of whey protein fractions with different degrees of enzymatic hydrolysis on the intestinal epithelium in health and disease with a novel 2D human intestinal organoid (HIO) monolayer model. In addition, we aimed to assess the anti-microbial activity and immune effects of the whey protein fractions. Human intestinal organoids were cultured from adult small intestines, and a model enabling apical administration of nutritional components during hypoxia-induced intestinal inflammation and normoxia (control) in crypt-like and villus-like HIO was established. Subsequently, the potential beneficial effects of whey protein isolate (WPI) and two whey protein hydrolysates with a 27.7% degree of hydrolysis (DH28) and a 50.9% degree of hydrolysis (DH51) were assessed. In addition, possible immune modulatory effects on human peripheral immune cells and anti-microbial activity on four microbial strains of the whey protein fractions were investigated. Exposure to DH28 prevented paracellular barrier loss of crypt-like HIO following hypoxia-induced intestinal inflammation with a concomitant decrease in hypoxia inducible factor 1 alpha (HIF1α) mRNA expression. WPI increased Treg numbers and Treg expression of cluster of differentiation 25 (CD25) and CD69 and reduced CD4+ T cell proliferation, whereas no anti-microbial effects were observed. The observed biological effects were differentially mediated by diverse whey protein fractions, indicating that (degree of) hydrolysis influences their biological effects. Moreover, these new insights may provide opportunities to improve immune tolerance and promote intestinal health.
Advanced Glycation End-Products and Their Effects on Gut Health
Authors: Phuong-Nguyen Kate , McNeill Bryony A. , Aston-Mourney Kathryn , Rivera Leni R.
Published: January 2023

Dietary advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed when reducing sugars are heated with proteins, amino acids, or lipids at high temperatures for a prolonged period. The presence and accumulation of AGEs in numerous cell types and tissues are known to be prevalent in the pathology of many diseases. Modern diets, which contain a high proportion of processed foods and therefore a high level of AGE, cause deleterious effects leading to a multitude of unregulated intracellular and extracellular signalling and inflammatory pathways. Currently, many studies focus on investigating the chemical and structural aspects of AGEs and how they affect the metabolism and the cardiovascular and renal systems. Studies have also shown that AGEs affect the digestive system. However, there is no complete picture of the implication of AGEs in this area. The gastrointestinal tract is not only the first and principal site for the digestion and absorption of dietary AGEs but also one of the most susceptible organs to AGEs, which may exert many local and systemic effects. In this review, we summarise the current evidence of the association between a high-AGE diet and poor health outcomes, with a special focus on the relationship between dietary AGEs and alterations in the gastrointestinal structure, modifications in enteric neurons, and microbiota reshaping.
Modifiable Risk Factors for Cardiovascular Disease among Women with and without a History of Hypertensive Disorders of Pregnancy
Authors: Slater Kaylee , Schumacher Tracy L. , Ding Ker Nee , Taylor Rachael M. , Shrewsbury Vanessa A. , Hutchesson Melinda J.
Published: January 2023

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in women. Hypertensive disorders of pregnancy (HDP) affect 5–10% of pregnancies worldwide, and are an independent risk factor for CVD. A greater understanding of the rates of modifiable CVD risk factors in women with a history of HDP can inform CVD prevention priorities in this group. The aim of this study was to understand the rates of individual and multiple modifiable risk factors for CVD (body mass index, fruit and vegetable intake, physical activity, sitting time, smoking, alcohol consumption and depressive symptoms) among women with a history of HDP, and assess whether they differ to women without a history of HDP. This study is a cross-sectional analysis of self-reported data collected for the Australian Longitudinal Study of Women’s Health (ALSWH). The sample included 5820 women aged 32–37 years old, who completed survey 7 of the ALSWH in 2015. Women with a history of HDP had a higher multiple CVD modifiable risk factor score compared to those without HDP (mean (SD): 2.3 (1.4) vs. 2.0 (1.3); p < 0.01). HDP history was significantly associated with a higher body mass index (p < 0.01), high-risk alcohol consumption (p = 0.04) and more depressive symptoms (p < 0.01). Understanding that women with a history of HDP have higher CVD risk factors, specifically body mass index, alcohol consumption and depressive symptoms, allows clinicians to provide appropriate and tailored CVD interventions for this group of women.
Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism
Authors: Alba Gonzalo , Dakhaoui Hala , Santa-Maria Consuelo , Palomares Francisca , Cejudo-Guillen Marta , Geniz Isabel , Sobrino Francisco , Montserrat-de la Paz Sergio , Lopez-Enriquez Soledad
Published: January 2023

Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of physiological processes. In an inflammatory microenvironment, these functional foods can interact with the immune system by modulating or balancing the exacerbated proinflammatory response. In this process, immune cells, such as antigen-presenting cells (APCs), identify danger signals and, after interacting with T lymphocytes, induce a specific effector response. Moreover, this conditions their change of state with phenotypical and functional modifications from the resting state to the activated and effector state, supposing an increase in their energy requirements that affect their intracellular metabolism, with each immune cell showing a unique metabolic signature. Thus, nutraceuticals, such as polyphenols, vitamins, fatty acids, and sulforaphane, represent an active option to use therapeutically for health or the prevention of different pathologies, including obesity, metabolic syndrome, and diabetes. To regulate the inflammation associated with these pathologies, intervention in metabolic pathways through the modulation of metabolic energy with nutraceuticals is an attractive strategy that allows inducing important changes in cellular properties. Thus, we provide an overview of the link between metabolism, immune function, and nutraceuticals in chronic inflammatory processes associated with obesity and diabetes, paying particular attention to nutritional effects on APC and T cell immunometabolism, as well as the mechanisms required in the change in energetic pathways involved after their activation.
Differences in the Microbiological Profile of Raw and Pasteurized Breastmilk from Hospital and Community-Based Donors at the First Human Milk Bank in Vietnam
Authors: Tran Hoang Thi , Nguyen Tuan Thanh , Nguyen Oanh Thi Xuan , Huynh Le Thi , Nguyen Le Thi , Nguyen Thao Thi , Le Huong Thi Thanh , Barnett Debbie , Weaver Gillian , Mathisen Roger
Published: January 2023

Background: Microbiological quality is one of the key safety standards in human milk bank (HMB) operations. We describe the profiles of bacteria in donor human milk (DHM) before and after the pasteurization of samples collected from breastfeeding women in the hospital and from the community in the first HMB in Vietnam. Methods: Data were collected between February 2017 and January 2022 from an online HMB monitoring system. First, DHM samples were cultured, and the number of colony-forming units (CFU) were counted before (n = 708) and after pasteurization (n = 1146). The gram-staining method combined with the Vitek 2 Compact system were used to identify types of organisms at the Da Nang Hospital for Women and Children’s Laboratory. Passing criteria for DHM included pre-pasteurization samples had a total colony count <105 CFU/mL and post-pasteurization was <10 CFU/mL. Results: During five years of operation, Da Nang HMB had 491 donors (48.7% were hospital and the rest community donors) who donated an average amount of 14.2 L over 45 days. Of this DHM volume, 84.9% of donor samples passed the pre- and post-pasteurization microbiological tests. DHM from community donors had a higher pass rate (87.8%) compared to that from hospital donors (79.5%). Before pasteurization, 15.4% of DHM samples had a bacteria count <103 CFU/mL, 63.0% had 103-<105 CFU/mL, and 21.6% had ≥105 CFU/mL. Most of the unpasteurized DHM samples (93.0%) had microorganism growth: with one organism (16.4%), two (33.9%), three or more (43.6%). After pasteurization, 17.9% samples had a bacteria count of 1–9 CFU/mL and 7.2% had ≥10 CFU/mL. DHM samples from community donors had a lower bacterial count and number of organisms than those from hospital donors both before and after pasteurization. The highest microorganisms from unpasteurized DHM samples were Staphylococcus epidermidis (74.2%), Acinetobacter sp. (52.1%), gram-positive bacillus (51.7%), Staphylococcus coagulase-negative (15.8%), and Staphylococcus aureus (10.5%). Common microorganisms from pasteurized DHM were gram-positive bacillus (21.0%), Staphylococcus epidermidis (3.9%), and Acinetobacter sp. (0.9%). Samples from the hospital tended to have a higher contamination with those microorganisms than those from community donors. Conclusions: The majority of DHM samples in Da Nang passed microbiological testing criteria. DHM from community donors had higher pass rates than hospital donors. Corrective actions are needed to improve HMB operations and hospital microbiological quality standards, as well as general improvements in water and sanitation.
Associations between the Dietary Inflammatory Index and Sleep Metrics in the Energy Balance Study (EBS)
Authors: Farrell Emily T. , Wirth Michael D. , McLain Alexander C. , Hurley Thomas G. , Shook Robin P. , Hand Gregory A. , Hébert James R. , Blair Steven N.
Published: January 2023

(1) Background: Sleep, a physiological necessity, has strong inflammatory underpinnings. Diet is a strong moderator of systemic inflammation. This study explored the associations between the Dietary Inflammatory Index (DII®) and sleep duration, timing, and quality from the Energy Balance Study (EBS). (2) Methods: The EBS (n = 427) prospectively explored energy intake, expenditure, and body composition. Sleep was measured using BodyMedia’s SenseWear® armband. DII scores were calculated from three unannounced dietary recalls (baseline, 1-, 2-, and 3-years). The DII was analyzed continuously and categorically (very anti-, moderately anti-, neutral, and pro-inflammatory). Linear mixed-effects models estimated the DII score impact on sleep parameters. (3) Results: Compared with the very anti-inflammatory category, the pro-inflammatory category was more likely to be female (58% vs. 39%, p = 0.02) and African American (27% vs. 3%, p < 0.01). For every one-unit increase in the change in DII score (i.e., diets became more pro-inflammatory), wake-after-sleep-onset (WASO) increased (βChange = 1.00, p = 0.01), sleep efficiency decreased (βChange = −0.16, p < 0.05), and bedtime (βChange = 1.86, p = 0.04) and waketime became later (βChange = 1.90, p < 0.05). Associations between bedtime and the DII were stronger among African Americans (βChange = 6.05, p < 0.01) than European Americans (βChange = 0.52, p = 0.64). (4) Conclusions: Future studies should address worsening sleep quality from inflammatory diets, leading to negative health outcomes, and explore potential demographic differences.
BIreactive: Expanding the Scope of Reactivity Predictions to Propynamides
Authors: Hermann Markus R. , Tautermann Christofer S. , Sieger Peter , Grundl Marc A. , Weber Alexander
Published: January 2023

We present the first comprehensive study on the prediction of reactivity for propynamides. Covalent inhibitors like propynamides often show improved potency, selectivity, and unique pharmacologic properties compared to their non-covalent counterparts. In order to achieve this, it is essential to tune the reactivity of the warhead. This study shows how three different in silico methods can predict the in vitro properties of propynamides, a covalent warhead class integrated into approved drugs on the market. Whereas the electrophilicity index is only applicable to individual subclasses of substitutions, adduct formation and transition state energies have a good predictability for the in vitro reactivity with glutathione (GSH). In summary, the reported methods are well suited to estimate the reactivity of propynamides. With this knowledge, the fine tuning of the reactivity is possible which leads to a speed up of the design process of covalent drugs.
Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity
Authors: Rybkin Alexander Yu. , Kurmaz Svetlana V. , Urakova Elizaveta A. , Filatova Natalia V. , Sizov Lev R. , Kozlov Alexey V. , Koifman Mikhail O. , Goryachev Nikolai S.
Published: January 2023

A series of nanoparticles (NPs) with a hydrodynamic radius from 20 to 100 nm in PBS was developed over the solubilization of hydrophobic dye methyl pheophorbide a (chlorin e6 derivative) by amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates. Photophysical properties and biological activity of the NPs aqueous solution were studied. It was found that the dye encapsulated in the copolymers is in an aggregated state. However, its aggregation degree decreases sharply, and singlet oxygen quantum yield and the fluorescence signal increase upon the interaction of these NPs with model biological membranes—liposomes or components of a tissue homogenate. The phototoxic effect of NPs in HeLa cells exceeds by 1.5–2 times that of the reference dye chlorin e6 trisodium salt—one of the most effective photosensitizers used in clinical practice. It could be explained by the effective release of the hydrophobic photosensitizer from the NPs into biological structures. The demonstrated approach can be used not only for the encapsulation of hydrophobic photosensitizers for PDT but also for other drugs, and N-vinylpyrrolidone amphiphilic copolymers show promising potential as a modern platform for the design of targeted delivery vehicles.
Synergistic Pro-Apoptotic Effect of a Cyclic RGD Peptide-Conjugated Magnetic Mesoporous Therapeutic Nanosystem on Hepatocellular Carcinoma HepG2 Cells
Authors: Zhao Xuanping , Liu Chuan , Wang Zichao , Zhao Yingyuan , Chen Xuyang , Tao Haizhen , Chen Hong , Wang Xueqin , Duan Shaofeng
Published: January 2023

Numerous nanocarriers have been developed to deliver drugs for the treatment of hepatocellular carcinoma. However, the lack of specific targeting ability, the low administration efficiency, and insufficient absorption by hepatocellular carcinoma cells, severely limits the therapeutic effect of the current drugs. Therefore, it is still of great clinical significance to develop highly efficient therapies with few side effects for the treatment of hepatocellular carcinoma. Herein, we developed a highly effective nanocarrier, cyclic RGD peptide-conjugated magnetic mesoporous nanoparticles (RGDSPIO@MSN NPs), to deliver the chemotherapeutic drug doxorubicin (DOX) to human hepatocellular carcinoma HepG2 cells, and further explored their synergistic apoptosis-promoting effects. The results showed that the prepared RGDSPIO@MSN NPs had good stability, biosafety and drug-loading capacity, and significantly improved the absorption of DOX by HepG2 cells, and that the RGDSPIO@MSN@DOX NPs could synergistically promote the apoptosis of HepG2 cells. Thus, this cyclic RGD peptide-modified magnetic mesoporous silicon therapeutic nanosystem can be regarded as a potentially effective strategy for the targeted treatment of hepatocellular carcinoma.
Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals
Authors: Nguyen Hiep X. , Nguyen Chien N.
Published: January 2023

Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate lipophilicity) due to the barrier function of the stratum corneum layer. Researchers have developed several physical enhancement techniques to expand the applications of the transdermal field; among these, microneedle technology has recently emerged as a promising platform to deliver therapeutic agents of any size into and across the skin. Typically, hydrophilic biomolecules cannot penetrate the skin by passive diffusion. Microneedle insertion disrupts skin integrity and compromises its protective function, thus creating pathways (microchannels) for enhanced permeation of macromolecules. Microneedles not only improve stability but also enhance skin delivery of various biomolecules. Academic institutions and industrial companies have invested substantial resources in the development of microneedle systems for biopharmaceutical delivery. This review article summarizes the most recent research to provide a comprehensive discussion about microneedle-mediated delivery of macromolecules, covering various topics from the introduction of the skin, transdermal delivery, microneedles, and biopharmaceuticals (current status, conventional administration, and stability issues), to different microneedle types, clinical trials, safety and acceptability of microneedles, manufacturing and regulatory issues, and the future of microneedle technology.
Interfacial Engineering Methods in Thermoplastic Composites: An Overview
Authors: Periasamy Kailashbalan , Kandare Everson , Das Raj , Darouie Maryam , Khatibi Akbar A.
Published: January 2023

The paper critically analyzed different interfacial enhancing methods used in thermoplastic composites. Although the absence of cross-linked polymer chains and chemical bonds on solidification enables the thermoplastics to be remelted, it creates weak interfacial adhesion between fibre reinforcements and the thermoplastic matrix. The weak fibre-matrix interface bonding reduces the efficiency with which the applied load can be transferred between these composite constituents, causing the composite to fail prematurely. Their need for high-temperature processing, poor compatibility with other polymer matrices, and relatively high viscosity render thermoplastics challenging when used to manufacture composite laminates. Therefore, various methods, including nanoparticles, changing the polarity of the fibre surface by plasma etching, chemical treatment with ozone, or an oxidative attack at the fibre surface, have been applied to improve the fibre/matrix bonding in thermoplastic composites. The fabrication steps followed in these techniques, their progress in research, and the associated toughening mechanisms are comprehensively discussed in this paper. The effect of different fibre-matrix interfacial enhancement methods on the mechanical properties of thermoplastic composites is also deliberated.
Effects of Calcium Carbonate Microcapsules and Nanohydroxyapatite on Properties of Thermosensitive Chitosan/Collagen Hydrogels
Authors: Arpornmaeklong Premjit , Jaiman Natthaporn , Apinyauppatham Komsan , Fuongfuchat Asira , Boonyuen Supakorn
Published: January 2023

Thermosensitive chitosan/collagen hydrogels are osteoconductive and injectable materials. In this study, we aimed to improve these properties by adjusting the ratio of nanohydroxyapatite particles to calcium carbonate microcapsules in a β-glycerophosphate-crosslinked chitosan/collagen hydrogel. Two hydrogel systems with 2% and 5% nanohydroxyapatite particles were studied, each of which had varying microcapsule content (i.e., 0%, 1%, 2%, and 5%). Quercetin-incorporated calcium carbonate microcapsules were prepared. Calcium carbonate microcapsules and nanohydroxyapatite particles were then added to the hydrogel according to the composition of the studied system. The properties of the hydrogels, including cytotoxicity and biocompatibility, were investigated in mice. The calcium carbonate microcapsules were 2–6 µm in size, spherical, with rough and nanoporous surfaces, and thus exhibited a burst release of impregnated quercetin. The 5% nanohydroxyapatite system is a solid particulate gel that supports homogeneous distribution of microcapsules in the three-dimensional matrix of the hydrogels. Calcium carbonate microcapsules increased the mechanical and physical strength, viscoelasticity, and physical stability of the nanohydroxyapatite hydrogels while decreasing their porosity, swelling, and degradation rates. The calcium carbonate microcapsules–nanohydroxyapatite hydrogels were noncytotoxic and biocompatible. The properties of the hydrogel can be tailored by adjusting the ratio of calcium carbonate microcapsules to the nanohydroxyapatite particles. The 1% calcium carbonate microcapsules containing 5% nanohydroxyapatite particle–chitosan/collagen hydrogel exhibited mechanical and physical strength, permeability, and prolonged release profiles of quercetin, which were superior to those of the other studied systems and were optimal for promoting bone regeneration and delivering natural flavonoids.
Synthesizing Polyurethane Using Isosorbide in Primary Alcohol Form, and Its Biocompatibility Properties
Authors: Hong Suk-Min , Kwon Hyuck-Jin , Lee Chil-Won
Published: January 2023

Isosorbide is a bio-based renewable resource that has been utilized as a stiffness component in the synthesis of novel polymers. Modified isosorbide-based bis(2-hydroxyethyl)isosorbide (BHIS) has favorable structural features, such as fused bicyclic rings and a primary hydroxyl function with improved reactivity to polymerization when compared to isosorbide itself. Polyurethane series (PBH PU series) using polycarbonate diol (PCD) and bis(2-hydroxyethyl)isosorbide (BHIS) were polymerized through a simple, one-shot polymerization without a catalyst using various ratios of BHIS, PCD, and hexamethylene diisocyanate (HDI). The synthesized BHIS and PUs were characterized using proton nuclear magnetic resonance (1H-NMR), Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), and mechanical testing. To determine the feasibility of using these PUs as biomedical materials, we investigated the effects of their BHIS content on PBH PU series physical and mechanical properties. The PBH PU series has excellent elasticity, with a breaking strain ranging from 686.55 to 984.69% at a 33.26 to 63.87 MPa tensile stress. The material showed superb biocompatibility with its high adhesion and proliferation in the bone marrow cells. Given their outstanding mechanical properties and biocompatibility, the polymerized bio-based PUs can contribute toward various applications in the medical field.
Aryloxy Ionic Liquid-Catalyzed Homogenous Esterification of Cellulose with Low-Reactive Acyl Donors
Authors: Yoshizawa Akina , Maruyama Chie , Kusuma Samuel Budi Wardhana , Wada Naoki , Kuroda Kosuke , Hirose Daisuke , Takahashi Kenji
Published: January 2023

Ionic liquids (ILs) are recyclable, non-volatile, and can dissolve cellulose, a natural polymer that is insoluble in versatile solvents. Therefore, ILs have been used to modify cellulose. However, 1-ethyl-3-methylimidazolium acetate (EmimOAc), a commercially available IL often used to dissolve and modify cellulose to prepare cellulose-based materials, causes the undesired introduction of an acetyl group derived from the acetate anion of EmimOAc onto the hydroxy group of cellulose during esterification. In this study, for cellulose esterification, we prepared aryloxy ILs as non-carboxylate-type and basic ILs, which can theoretically prevent the undesired introduction of an acyl group from the IL onto the hydroxy group of cellulose. The optimized 1-ethyl-3-methylimidazolium 2-pyridinolate (Emim2OPy) and mixed solvent system achieved rapid cellulose esterification (within 30 min) with an excellent degree of substitution (DS) value (up to >2.9) derived from the employed low-reactive vinyl esters and bio-based unsaturated aldehydes, without any undesired substituent introduction from side reactions.
Analysis of the Resistance Change of Chemosensitive Layers to the Presence of Ammonia Vapors under Variable Conditions of Air Temperature and Humidity
Authors: Zajączkowska Hanna , Brochocka Agnieszka , Nowak Aleksandra , Wojtkiewicz Mateusz
Published: January 2023

The developed chemosensitive layers consisted of multi-walled carbon nanotubes (MWCNTs), reduced graphene oxide (rGO), and a conductive polymer (polyaniline—PANI) in a polymeric matrix (a polystyrene solution in methylene chloride). The layers were challenged with a test gas to determine the optimum variant in terms of sensitivity to the selected analyte and the repeatability of results. In terms of individual components, the greatest percentage change in resistance (32%) and the best repeatability were found for chemosensitive layers containing a PANI salt in the polymeric matrix. Even greater changes in resistance were exhibited by sensors containing more than one active component in the matrix: 45% for PANI + MWCNTs and 75% for PANI + rGO. The presented method of thin-layer deposition was shown to be suitable for the production of sensitive and functional sensors of ammonia vapors. The developed sensors were characterized by high repeatability and sensitivity to a harmful substance that constitutes an inhalation hazard to workers. The sensors were also analyzed for their durability and recovery as well as the ability to function under varying temperature and humidity conditions.
Adsorption Characteristics for Cu(II) and Phosphate in Chitosan Beads under Single and Mixed Conditions
Authors: Kim Taehoon , Shin Jeongwoo , An Byungryul
Published: January 2023

Chitosan, a natural organic polymer, has shown bifunctional characteristics in the removal of cationic and anionic contaminants from water and wastewater treatment. In particular, cationic Cu(II) and anionic phosphate can simultaneously interact with chitosan owing to the presence of the amino group in the form of NH2 and NH3+ in chitosan. To gain greater insight into the bifunctional adsorption characteristics of chitosan, its adsorption capacity for Cu(II) and phosphate was tested under single and mixed (co-ion) conditions to investigate the interactions between four types of chitosan beads and NH2 and NH3+. In the single condition, Cu(II) uptake was reduced from 0.243 to 0.0197 mmol/g due to the crosslinking and drying processes, whereas no significant reduction in phosphate uptake was observed, indicating that the crosslinking agent only interacted with NH2 to decrease the number of available adsorption sites for Cu(II). Under the mixed condition, the simultaneous presence of the two ions clearly increased the uptake of each other, with the adsorption of phosphate being more influenced than that of Cu(II). The comparison of the rate constant, k1 or k2, using pseudo-first- and pseudo-second-order models confirmed that phosphate reached equilibrium faster than Cu(II), suggesting that electrostatic interaction was preferred over coordination. In addition, under mixed conditions, co-ion competition slowed down the adsorption kinetics for both Cu(II) and phosphate.
Impact of Zinc Oxide Addition on Oil Palm Empty Fruit Bunches Foamed Polymer Composites for Automotive Interior Parts
Authors: Adlie Taufan Arif , Ali Nurdin , Huzni Syifaul , Ikramullah Ikramullah , Rizal Samsul
Published: January 2023

The sustainable use of agricultural waste to generate valuable products while minimizing environmental burdens is increasing rapidly. Multiple sources of fibers have been intensively studied concerning their application in various fields and industries. However, few publications have extensively discussed the property’s performance of oil palm empty fruit bunches (OPEFB) composites. With main properties similar to composites currently listed for industrial applications, OPEFB is worth listing as a potential composite for industrial applications and non-structural material alternatives. OPEFB-reinforced polymer composites are expected to be applied to automotive interior parts. This study aims to determine the effect of adding zinc oxide (ZnO) and polyurethane on OPEFB-reinforced polymer composites for automotive interior parts. This composite was produced using the hand lay-up method with 70% resin, 15% OPEFB fiber, 15% polyurethane as a blowing agent, and four variations of ZnO at 5%, 10%, 15%, and 20%. The OPEFB particle sizes are 40, 60, 80, and 100, respectively. The composite was examined to determine mechanical, morphology, chemical, and thermal characteristics. It was observed that the addition of 20% ZnO caused ZnO agglomeration, weakening the interfacial bond between OPEFB particles, polyester, polyurethane, and ZnO filler. Overall, the results showed that adding ZnO and polyurethane to the composite increased tensile, compressive, flexural, and impact strength, as well as thermal stability with more significant values up to 160%, 225%, 100%, 100%, and 4.3%, respectively. This result depicted that the best composition was specimens with 15% ZnO and 149 microns OPEFB fibers particle size. It is considered a promising candidate to be applied in automotive interior components.
Dynamic Response and Deformative Mechanism of the Shape Memory Polymer Filled with Low-Melting-Point Alloy under Different Dynamic Loads
Authors: Wang Huanhuan , Zhang Yongqiang , Tan Zhuhua
Published: January 2023

Low-melting-point alloy (LMPA) was used as an additive to prepare epoxy-resin-based shape memory polymer composites (LMPA/EP SMP), and dynamic mechanical analyzer (DMA) tests were performed to demonstrate the shape memory effect, storage modulus, and stiffness of the composites under different load cases. The composites exhibited an excellent shape recovery ratio and shape fixity ratio, and a typical turning point was observed in the storage modulus curves, which was attributed to the melting of the LMPA. In order to investigate the dynamic deformation mechanism at high strain rates, split Hopkinson pressure bar (SHPB) experiments were performed to study the influence of the strain rate and plastic work on the dynamic mechanical response of LMPA/EP composites. The results showed that there was a saturated tendency for the flow stress with increasing strain rate, and the composites exhibited a typical brittle failure mode at high strain rate. Moreover, an obvious melting phenomenon of the LMPA was observed by SEM tests, which was due to the heat generated by the plastic work at high strain rate. The fundamental of the paper provided an effective approach to modulate the stiffness and evaluate the characteristics of SMP composites.
Chitosan–Cu Catalyzed Novel Ferrocenated Spiropyrrolidines: Green Synthesis, Single Crystal X-ray Diffraction, Hirshfeld Surface and Antibacterial Studies
Authors: Asad Mohammad , Arshad Muhammad Nadeem , Asiri Abdullah M. , Rahman Mohammed M. , Kumaran Snigdha , Thorakkattil Neerankuzhiyil Mohammed Musthafa
Published: January 2023

Chitosan-bounded copper (chitosan–Cu) was introduced for green synthesis of novel ferrocenated spiropyrrolidine hybrids, namely 3′-(4-.bromobenzoyl)-5′-(4-hydroxybenzyl)-4′-ferrocenylspiro[indoline-3,2′-pyrrolidin]-2-one and 3′-(4-bromobenzoyl)-4′-ferrocenylspiro[indoline-3,2′-pyrrolidin]-2-one, in good yield. A one-pot three-component 1,3-dipolar cycloaddition reaction was employed for the formation of spiropyrrolidines from 1-(4-bromophenyl)-ferrocene-prop-2-en-1-one and azomethine ylides, which were developed in situ from tyrosine, glycine, and isatin, respectively. Various spectroscopic methods were used to establish the structures of spiropyrrolidines, and a single crystal X-ray diffraction study of a spiropyrrolidine provided additional confirmation. The crystallographic study revealed that compound 3a has one independent molecule in its unit cell, which is correlated with Hirshfeld surface analysis, and describes intramolecular contacts adversely. The highly yielded products in green conditions were determined for their antibacterial significance and were found to have good activity against Gram-positive and Gram-negative bacterial strains.
A Comparative Study of Religious Images on Sogdian Burial Utensils in China and Central Asia
Authors: Han Jing , Wang Xiaoyang
Published: January 2023

The comparison of Sogdian images in China and Central Asia has become a hot topic in academic circles in recent years. However, there is no specific comparison of Sogdian images on burial utensils in the existing studies. Accordingly, the author proposes to compare the images on burial utensils by collecting together the remaining materials as much as possible and making corresponding data tables. First and foremost, this paper focuses on the actual quantity of the remains and gives a table, “Statistics of the Sogdian Burial Utensils with Images”, to show this quantity for the first time: there are 30 remains of Sogdian burial utensils in China (26 sarcophagi and four ossuaries) and 23 Sogdian burial utensils in Central Asia (all are ossuaries). Secondly, there are several tables based on remaining materials in this paper, including “Distribution of the Shapes of Sogdian Sarcophagi in China”, “Historical Period and Shape of Sogdian Ossuaries in Central Asia”, “Religious Images Table of Sogdian Sarcophagi in China”, “Table of Religious Image Types of the Sogdian Ossuaries in Central Asia” and “Common Religious Images of the Burial Utensils in China and Central Asia”. Thirdly, further analysis shows that there are two image systems. Grounded in the above analysis, this paper comes to conclusions at three levels. Firstly, there are two shapes of burial utensils. Sarcophagi are widely seen in China whilst ossuaries are commonly discovered in Central Asia. As a result, the images on the sarcophagi in China are large in size and wide in narrative themes, whereas those on the ossuaries in Central Asia are small in size, emphasizing important content and narrative themes. All are rich in image representation. Secondly, there are three types of religious images on the burial utensils. The comparison results of image types show the common images in three categories: gods, funeral ceremonies and sacred fire sacrifice. Thirdly, the images on burial utensils have different characteristics regarding religious transmission. Zoroastrianism is dominant in Central Asia, while Zoroastrianism, Chinese mythology and Buddhist images are primary in China and images of tomb owners embodying secularity are also widespread in China.
Methods for Measuring and Assessing Irregularities of Stone Pavements—Part I
Authors: Loprencipe Giuseppe , Bruno Salvatore , Cantisani Giuseppe , D’Andrea Antonio , Di Mascio Paola , Moretti Laura
Published: January 2023

Stone pavements are the historical, architectural, and cultural heritage of lots of cities in Italy and the world. Road managers should be able to make decisions on the global conditions to define the most suitable strategies and maintenance interventions for every type of pavement. There are no standard monitoring methods or criteria for evaluating stone pavement performance. These pavements have more uneven surfaces than traditional pavements, but this characteristic could be accepted if type of vehicles and relative travel conditions are considered. Therefore, it is useful to define criteria for assessing roughness considering the comfort experienced by users in different vehicles. In this research, both traditional and innovative methodologies for assessing irregularities have been investigated using true stone surface profiles. In this regard, traditional performance indicators such as the International Roughness Index (IRI) defined by the ASTM E1926, the ISO 8608 classification, and the frequency-weighted vertical acceleration (awz) provided by ISO 2631-1 for comfort assessment have been considered. In the case of comfort assessment, three dynamic vehicle models (bike, automobile, and bus) have been adopted. Finally, this two-part paper also proposes an innovative straightedge analysis for stone pavements (SASP) to evaluate the effect on traffic of both pavement profile roughness and localized irregularities. In this way, the authors aim to provide an effective tool to monitor stone pavements.
Translating Indigenous Knowledge into Actionable Climate-Change Adaption Strategies: A Case Study of Maluti-a-Phofung Local Municipality, Free State Province, South Africa
Authors: Muchaku Shadreck , Magaiza Grey , Hamandawana Hamisai
Published: January 2023

Although the literature concerning vulnerabilities to climate change (CC) has been growing, research continues to be silent on approaches that can enhance the adaptive capacities of resource-poor communities that are vulnerable to the adverse effects of CC by translating indigenous knowledge (IK) into actionable adaptation strategies. This assertion is premised on the absence of concerted efforts to incorporate IK into science-based adaptation strategies. We attempt to address this gap by using a multidisciplinary investigative approach that taps into the perceptions of local people in the Maluti-a-Phofung Local Municipality in the Free state province of South Africa and what is available in the literature. This approach is helpful because it ensures that local people’s perceptions, alongside other objectively informed insights, are systematically integrated into the co-designing of actionable climate-change adaption strategies. Given these and other considerations, we invite the scientific community and those interested in sustainability to complement our efforts by providing suggestions on the way forward.
Mechanical Behaviour of Steel Slag–Rubber Mixtures: Laboratory Assessment
Authors: Alves Rubens , Rios Sara , Fortunato Eduardo , Viana da Fonseca António , Guimarães Delgado Bruno
Published: January 2023

Slags and rubber from end-of-life tires represent a liability to the steel and tire industry, causing economic and environmental problems that are difficult to manage. Transport infrastructures can use these industrial by-products instead of extracting natural raw materials, but the adequate mechanical performance of the materials needs to be assured. This paper addresses the mechanical behaviour of slag–rubber mixtures in the laboratory with CBR, monotonic and cyclic triaxial tests. In addition, light falling weight deflectometer tests were also performed in a physical model. The results were analysed to meet technical specifications from Brazil, Portugal and Australia using railway sub-ballast layers, capping layers or road pavement layers as the base and sub-base to identify the applicability range of slag–rubber mixtures for transport infrastructures. Concerning the analysed parameters, it was demonstrated that slag–rubber mixtures can show resilient behaviour and strength adequate for the support layers of transport infrastructures provided that the rubber content is below 5% in weight and that the slag is milled to comply with the grain size distribution ranges available in the technical specifications of the cited countries.
Does China’s Regional Digital Economy Promote the Development of a Green Economy?
Authors: Zhang Weiwei , Zhang Shengqiang , Bo Lan , Haque Mahfuzul , Liu Enru
Published: January 2023

As countries worldwide are pursuing green development, assessing whether the digital economy as a new economic engine can help us achieve new breakthroughs is of great research value. China, being the largest resource consumer in the world but with a rapidly developing digital economy, can offer us a special view on this question. Using China’s provincial panel data from 2010 to 2020, this study comprehensively measures the development of the digital economy from four dimensions and empirically examines the impact of digital economy development on the green economy based on the super efficiency SBM-GML model. The results show that: first, digital economy development has a significant positive effect on promoting a green economy; second, there are regional differences in both the digital economy and the green economy in China, with the development in the southern region better than that in the northern region; third, the environmental regulation has a double-threshold effect on the relationship that we assessed. The findings in this study highlight the importance of digital economic development in driving the growth of the real economy and are of value to the development of a green economy in the new period.
The Bi-Functional Paxilline Enriched in Skin Secretion of Tree Frogs (Hyla japonica) Targets the KCNK18 and BKCa Channels
Authors: Yin Chuanling , Zeng Fanpeng , Huang Puyi , Shi Zhengqi , Yang Qianyi , Pei Zhenduo , Wang Xin , Chai Longhui , Zhang Shipei , Yang Shilong , Dong Wenqi , Lu Xiancui , Wang Yunfei
Published: January 2023

The skin secretion of tree frogs contains a vast array of bioactive chemicals for repelling predators, but their structural and functional diversity is not fully understood. Paxilline (PAX), a compound synthesized by Penicillium paxilli, has been known as a specific antagonist of large conductance Ca2+-activated K+ Channels (BKCa). Here, we report the presence of PAX in the secretions of tree frogs (Hyla japonica) and that this compound has a novel function of inhibiting the potassium channel subfamily K member 18 (KCNK18) channels of their predators. The PAX-induced KCNK18 inhibition is sufficient to evoke Ca2+ influx in charybdotoxin-insensitive DRG neurons of rats. By forming π-π stacking interactions, four phenylalanines located in the central pore of KCNK18 stabilize PAX to block the ion permeation. For PAX-mediated toxicity, our results from animal assays suggest that the inhibition of KCNK18 likely acts synergistically with that of BKCa to elicit tingling and buzzing sensations in predators or competitors. These results not only show the molecular mechanism of PAX-KCNK18 interaction, but also provide insights into the defensive effects of the enriched PAX.
Highly Evolvable: Investigating Interspecific and Intraspecific Venom Variation in Taipans (Oxyuranus spp.) and Brown Snakes (Pseudonaja spp.)
Authors: van Thiel Jory , Alonso Luis L. , Slagboom Julien , Dunstan Nathan , Wouters Roel M. , Modahl Cassandra M. , Vonk Freek J. , Jackson Timothy N. W. , Kool Jeroen
Published: January 2023

Snake venoms are complex mixtures of toxins that differ on interspecific (between species) and intraspecific (within species) levels. Whether venom variation within a group of closely related species is explained by the presence, absence and/or relative abundances of venom toxins remains largely unknown. Taipans (Oxyuranus spp.) and brown snakes (Pseudonaja spp.) represent medically relevant species of snakes across the Australasian region and provide an excellent model clade for studying interspecific and intraspecific venom variation. Using liquid chromatography with ultraviolet and mass spectrometry detection, we analyzed a total of 31 venoms covering all species of this monophyletic clade, including widespread localities. Our results reveal major interspecific and intraspecific venom variation in Oxyuranus and Pseudonaja species, partially corresponding with their geographical regions and phylogenetic relationships. This extensive venom variability is generated by a combination of the absence/presence and differential abundance of venom toxins. Our study highlights that venom systems can be highly dynamical on the interspecific and intraspecific levels and underscores that the rapid toxin evolvability potentially causes major impacts on neglected tropical snakebites.