bluuebunny/crossref_metadata_2025 huggingface dataset:
Augmented reality-assisted versus conventional total hip arthroplasty: a systematic review and meta-analysis
Authors: Su Shilong , Wang Ruideng , Chen Zhengyang , Zhou Fang , Zhang Yunqing
Published: December 2023

Background

Extended reality (XR), including virtual reality, augmented reality (AR), and mixed reality, has been used to help achieve accurate acetabular cup placement in total hip arthroplasty (THA). This study aimed to compare the differences between XR-assisted and conventional THA.

Methods

In this systematic review and meta-analysis, electronic databases including PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), and clinicaltrials.gov were searched for studies from inception to September 10, 2023. The outcomes were accuracy of inclination and anteversion, duration of surgery, and intraoperative blood loss. Meta-analysis was performed using Review Manager 5.4 software.

Results

A total of five studies with 396 patients were included in our study. The pooled results indicated AR-assisted THA had better accuracy of inclination and anteversion than conventional THA (SMD = − 0.51, 95% CI [− 0.96 to − 0.07], P = 0.02; SMD = − 0.96, 95% CI [− 1.19 to − 0.72], P < 0.00001), but duration of surgery and intraoperative blood loss were similar in the two groups.

Conclusion

This systematic review and meta-analysis found that AR-assisted THA had better accuracy of inclination and anteversion than conventional THA, but the duration of surgery and intraoperative blood loss were similar in the two groups. Based on the pooled results, we suggested that AR can provide more precise acetabular cup placement than conventional methods in THA.
Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis
Authors: Dai Weiqi , Wu Xiaoli , Li Jingjing , Tang Wenxi , Wang Ying , Xu Wenqiang , Han Dengyu , Xu Xiaorong , Xu Xuanfu
Published: December 2023

Background

Hedgehog-Gli1 signaling induces development of two common neurological features seen in pancreatic ductal adenocarcinoma (PDAC): peripheral neural invasion (PNI) and peripheral neural remodeling (PNR). However, the underlying molecular mechanisms in cancer cells and nerves within Gli1-derived PNR have not previously been comprehensively analyzed.

Methods

In this study, RNA sequencing was used to screen meaningful circRNAs in PNR. An in vitro model of PNR was subsequently constructed through a co-culture system comprising PDAC cells and murine dorsal root ganglia (DRG) (as the neuronal element), and the relevant mechanisms were explored using a series of molecular biology experiments. A subcutaneous nude mouse tumorigenesis model was established to further verify the occurrence of PNR that was detected in human PDAC samples.

Results

We first confirmed the molecular mechanisms of PNR development through crosstalk between exosomal circ-0011536 and DRG. In Gli1-overpressed PDAC, circ-0011536 is mainly secreted by exosomes. After being ingested by DRG, it can promote the activity of DRG by degrading miR-451a and upregulating the expression of VGF. Overexpression of Gli1 can accelerate the proliferation of subcutaneous tumors in mice and is closely related to the density of nerve plexuses, while downregulating circ-RNA inhibits tumor proliferation and reduces the density of nerve plexuses. In addition, TMA results confirmed that Gli1 overexpression significantly increased the expression of VGF and was closely associated with increased nerve plexus density.

Conclusion

Hedgehog-Gli1-induced exosomal circ-0011536 promoted PNR via the miR-451a/VGF axis, thereby establishing that it may contribute to PDAC-associated nerve changes with activated Hedgehog signaling.
Hybrid-hybrid correction of errors in long reads with HERO
Authors: Kang Xiongbin , Xu Jialu , Luo Xiao , Schönhuth Alexander
Published: December 2023

Although generally superior, hybrid approaches for correcting errors in third-generation sequencing (TGS) reads, using next-generation sequencing (NGS) reads, mistake haplotype-specific variants for errors in polyploid and mixed samples. We suggest HERO, as the first “hybrid-hybrid” approach, to make use of both de Bruijn graphs and overlap graphs for optimal catering to the particular strengths of NGS and TGS reads. Extensive benchmarking experiments demonstrate that HERO improves indel and mismatch error rates by on average 65% (27$$\sim$$
∼
95%) and 20% (4$$\sim$$
∼
61%). Using HERO prior to genome assembly significantly improves the assemblies in the majority of the relevant categories.
The association between the metabolic score for insulin resistance (METS-IR) index and urinary incontinence in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2001–2018
Authors: Cao Shangqi , Meng Linghao , Lin Lede , Hu Xu , Li Xiang
Published: December 2023

Background

The association between insulin resistance and urinary incontinence (UI) has not been investigated widely. The purpose of this study is to assess the relationship between a novel indicator for assessing insulin resistance the metabolic score for insulin resistance (METS-IR) index and urinary incontinence (UI).

Methods

This study utilized data from National Health and Nutrition Examination Survey (NHANES) 2001–2018. Weighted multivariable logistic regression models were conducted to explore the association of METS-IR index with three types of UI [stress UI (SUI), urgency UI (UUI), and mixed UI (MUI)]. Smooth curve fitting was utilized to investigate the linear relationship. Subgroup analysis was used to examine the stability of the connection between METS-IR index and UI in different stratifications.

Results

A total of 17,474 participants were included in this study, of whom 23.76% had SUI, 20.05% had UUI, and 9.59% had MUI. METS-IR index was positively associated with three types of UI with full adjustment [SUI: odds ratio (OR) = 1.023, 95% confidence interval (CI) 1.019–1.027; UUI: OR = 1.015, 95% CI 1.011–1.019; MUI: OR = 1.020, 95% CI 1.016–1.025, all p < 0.001]. After transferring METS-IR index into a categorical variable by quartiles, the positive connection between METS-IR index and UI was still observed in the highest METS-IR group compared to the lowest METS-IR interval (SUI: OR = 2.266, 95% CI 1.947–2.637, p < 0.001; UUI: OR = 1.534, 95% CI 1.344–1.750, p < 0.001; MUI: OR = 2.044, 95% CI 1.707–2.448, p < 0.001). The analysis of smooth curves fitting showed that METS-IR index was positively linearly related to three types of UI. Moreover, the association between METS-IR index and SUI was more significant in females compared to males (p for interaction < 0.05).

Conclusion

An elevated METS-IR index was related to increased risks of three types of UI (SUI, UUI, and MUI) in the United States population. METS-IR index was more significantly connected to SUI in females than males. The association between insulin resistance and UI needs to be explored with more studies.
Adipose tissue specific insulin resistance and prognosis of nondiabetic patients with ischemic stroke
Authors: Zhou Qi , Yan Hongyi , Jin Aoming , Meng Xia , Lin Jinxi , Li Hao , Wang Yongjun , Pan Yuesong
Published: December 2023

Background

Insulin resistance is linked to atherosclerotic cardiovascular diseases and stroke, whereas less is known about adipose tissue specific insulin resistance and outcomes after ischemic stroke. This study aimed to estimate the association between adipose tissue specific insulin resistance and prognosis of nondiabetic patients with ischemic stroke.

Methods

Patients with ischemic stroke without a history of diabetes mellitus in the Third China National Stroke Registry were included. Adipose tissue specific insulin resistance index (Adipo-IR) was calculated by fasting serum insulin and free fatty acids and categorized into 5 groups according to the quintiles. Outcomes included stroke recurrence (ischemic or hemorrhagic), combined vascular events, all-cause death, and poor outcome (modified Rankin Scale, 3–6) at 12 months after stroke onset. We assessed the association between Adipo-IR and risk of prognosis by multivariable Cox/logistic regression models adjusted for potential covariates.

Results

Among 2,222 patients, 69.0% were men with a mean age of 62.5 years. At 12 months, 185 (8.3%) patients had recurrent stroke, 193 (8.7%) had combined vascular events, 58 (2.6%) died, and 250 (11.5%) had a poor outcome. Compared with patients with the lowest quintile, patients with the second, third, fourth, fifth quintiles of the Adipo-IR were associated with an increased risk of stroke recurrence (hazard ratio [HR], 1.77; 95% CI, 1.04–3.03; P = 0.04; HR, 2.19; 95% CI, 1.30–3.68; P = 0.003; HR, 1.84; 95% CI, 1.06–3.21; P = 0.03; HR, 2.11; 95% CI, 1.20–3.71; P = 0.01, respectively) and marginally associated with an increased risk of combined vascular events ( HR, 1.60; 95%CI, 0.97–2.64; P = 0.07; HR, 1.91; 95% CI, 1.17–3.13; P = 0.01; HR, 1.62; 95% CI, 0.96–2.75; P = 0.07; HR, 1.80; 95% CI, 1.05–3.09; P = 0.03, respectively) at 12 months after adjustment for potential covariates. Adipo-IR was not associated with mortality and poor outcome at 12 months.

Conclusions

These findings suggest that adipose tissue specific insulin resistance is independently associated with recurrent stroke and combined vascular events after acute ischemic stroke in nondiabetic patients.
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
Authors: Saddiki Hachem , Zhang Xueying , Colicino Elena , Wilson Ander , Kloog Itai , Wright Robert O. , Wright Rosalind J. , Lesseur Corina
Published: December 2023

Background

Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. The placenta is a central regulator of the in utero environment that orchestrates development and postnatal life via fetal programming. Ambient air pollution contaminants can reach the placenta and have been shown to alter bulk placental tissue DNA methylation patterns. Yet the effect of air pollution on placental cell-type composition has not been examined. We aimed to investigate whether the exposure to ambient air pollution during gestation is associated with placental cell types inferred from DNA methylation profiles.

Methods

We leveraged data from 226 mother–infant pairs in the Programming of Intergenerational Stress Mechanisms (PRISM) longitudinal cohort in the Northeastern US. Daily concentrations of fine particulate matter (PM2.5) at 1 km spatial resolution were estimated from a spatiotemporal model developed with satellite data and linked to womens’ addresses during pregnancy and infants’ date of birth. The proportions of six cell types [syncytiotrophoblasts, trophoblasts, stromal, endothelial, Hofbauer and nucleated red blood cells (nRBCs)] were derived from placental tissue 450K DNA methylation array. We applied compositional regression to examine overall changes in placenta cell-type composition related to PM2.5 average by pregnancy trimester. We also investigated the association between PM2.5 and individual cell types using beta regression. All analyses were performed in the overall sample and stratified by infant sex adjusted for covariates.

Results

In male infants, first trimester (T1) PM2.5 was associated with changes in placental cell composition (p = 0.03), driven by a decrease [per one PM2.5 interquartile range (IQR)] of 0.037 in the syncytiotrophoblasts proportion (95% confidence interval (CI) [− 0.066, − 0.012]), accompanied by an increase in trophoblasts of 0.033 (95% CI: [0.009, 0.064]). In females, second and third trimester PM2.5 were associated with overall changes in placental cell-type composition (T2: p = 0.040; T3: p = 0.049), with a decrease in the nRBC proportion. Individual cell-type analysis with beta regression showed similar results with an additional association found for third trimester PM2.5 and stromal cells in females (decrease of 0.054, p = 0.024).

Conclusion

Gestational exposure to air pollution was associated with placenta cell composition. Further research is needed to corroborate these findings and evaluate their role in PM2.5-related impact in the placenta and consequent fetal programming.
“Y” anastomosis, a solution in doubtful venous anastomosis: a case report and review of the literature
Authors: Mohammadi Soha , Taghizadeh Mortezaei Nima , Abdollahi Arash , Mohammadi Shabahang
Published: December 2023

Background

Lower lip squamous cell carcinoma is a significant subtype of head and neck cancer, constituting about 25–30% of cases. Traditional surgical methods, like primary closure, have limitations in managing large resections of lip tumors. Recent advancements in surgical techniques, particularly free flaps, have shown promising results in addressing these challenges. The Y-shaped anastomosis is an innovative approach aimed at enhancing the efficiency of microvascular free flap surgeries for improved lip cancer reconstruction outcomes.

Case presentation

A 77-year-old Persian male with lower lip squamous cell carcinoma underwent tumor resection with a 2 cm safety margin, bilateral neck dissection, and lip reconstruction using the right radial forearm free flap. The surgery incorporated a Y-shaped anastomosis to improve venous pedicle outcomes.

Conclusion

In this case, it was decided not to open the first anastomosis but to add the second end to the side one to provide two vascular supports for the venous anastomosis. Y anastomosis makes the surgery easier and decreases complications resulting from vascular size mismatch.
PDBe CCDUtils: an RDKit-based toolkit for handling and analysing small molecules in the Protein Data Bank
Authors: Kunnakkattu Ibrahim Roshan , Choudhary Preeti , Pravda Lukas , Nadzirin Nurul , Smart Oliver S. , Yuan Qi , Anyango Stephen , Nair Sreenath , Varadi Mihaly , Velankar Sameer
Published: December 2023

While the Protein Data Bank (PDB) contains a wealth of structural information on ligands bound to macromolecules, their analysis can be challenging due to the large amount and diversity of data. Here, we present PDBe CCDUtils, a versatile toolkit for processing and analysing small molecules from the PDB in PDBx/mmCIF format. PDBe CCDUtils provides streamlined access to all the metadata for small molecules in the PDB and offers a set of convenient methods to compute various properties using RDKit, such as 2D depictions, 3D conformers, physicochemical properties, scaffolds, common fragments, and cross-references to small molecule databases using UniChem. The toolkit also provides methods for identifying all the covalently attached chemical components in a macromolecular structure and calculating similarity among small molecules. By providing a broad range of functionality, PDBe CCDUtils caters to the needs of researchers in cheminformatics, structural biology, bioinformatics and computational chemistry.

Graphical Abstract
Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock
Authors: Helms Julie , Merdji Hamid , Loewert Sébastien , Severac François , Monnier Alexandra , Kaurin Julian , Curtiaud Anaïs , Meziani Ferhat , Demiselle Julien
Published: December 2023

Background

Disseminated intravascular coagulation (DIC) worsens the prognosis of septic shock and contributes to multiple organ failure. To date, no data linking DIC and acute kidney injury (AKI) occurrence, severity, and evolution in this setting are available. We aimed at analyzing the association between AKI occurrence, severity and evolution in patients with septic shock-induced DIC. In a prospective monocentric cohort study, consecutive patients, 18 years and older, admitted in the ICU of Strasbourg University Hospital in the setting of systemic hypotension requiring vasopressor related to an infection, without history of terminal chronic kidney disease were eligible. AKI was defined according to the KDIGO classification. DIC diagnosis was based on the International Society on Thrombosis and Haemostasis (ISTH) score. Evolution of AKI was evaluated through the composite endpoint of major adverse kidney events. Only patients with DIC that occurred before or at the time of AKI diagnosis were considered. Univariate and multivariate analysis were performed to determine factors associated with renal outcomes.

Results

350 patients were included, of whom 129 experienced DIC. Patients with DIC were more seriously ill (median SAPS II 64 vs. 56, p < 0.001), and had higher 28-day mortality (43.3% vs. 26.2%, p < 0.001). AKI was more frequent in patients with DIC (86.8% vs. 74.2%, p < 0.005), particularly for the more severe stage of AKI [KDIGO 3 in 58.1% of patients with DIC vs. 30.8% of patients without DIC, p < 0.001, AKI requiring renal replacement therapy (RRT) in 47.3% of patients with DIC vs. 21.3% of patients without DIC, p < 0.001]. After adjustment for confounding factors, DIC occurrence remained associated with the risk of having the more severe stage of AKI with an odds ratio (OR) of 2.74 [IC 95% (1.53–4.91), p < 0.001], and with the risk of requiring RRT during the ICU stay [OR 2.82 (1.53–5.2), p < 0.001].

Conclusion

DIC appears to be strongly associated with the risk of developing the more severe form of AKI (stage 3 of the KDIGO classification, RRT requirement), even after adjustment for severity and other relevant factors.
Family-led learning through parenting in family business
Authors: Tanan Antonius , Cahyadi Hadi , Tan Jacob Donald , Yew Lee Kean
Published: December 2023

This paper aims to conceptualize a family business parenting approach called family-led learning to break the third-generational curse in family business. This means that family business can hardly surpass the third generation. Family enterprises is expected to represent approximately 40 percent of the world’s largest corporations by 2025, but this will not come to realization if parenting approach is not learned by the leaders of the family and experienced by the next generations. In Indonesia, family business composes around 95 percent of all the businesses and contributes about 80 percent to the country’s economy. Since it is crucial to sustain the family business in Indonesia, theorizing the parenting approach for succession is vital. Applying grounded theory, this inquiry constructed the “Parenting to Equip” category in Parenting–Harmonizing–Collaborating (PHC) theory by interviewing 28 participants from four family conglomerates that are public-listed companies and are planning beyond the third generation. Next, this study integrated the Community of Inquiry (CoI) theory to the “Parenting to Equip” component to create a deep and meaningful learning experience. This results in the Family-Led Learning in Family Business (FLL-FB) concept that enable effective parenting to equip the next generations. This novel insight denotes parents of family businesses must incorporate entrepreneurial training into their parenting practices through nonformal learning experiences in informal learning environments to equip the next generations become potential successors.
Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease
Authors: Yu Cheng-Wei , Chen Chia-Hung , Cheng Yung-Chi , Hsieh Wen-Che , Hsu Tzu-Ju , Tsai Fuu-Jen , Hsu Chao-Yu
Published: December 2023

Background

Disease-related stress can trigger the occurrence of herpes zoster (HZ). Fatty liver disease (FLD) can have adverse effects on the human body and may induce stress in affected individuals. In this study, we investigated whether FLD is associated with an elevated risk of HZ.

Methods

For this study, we utilized data from the National Health Insurance Research Database, patients with FLD from 2000 to 2017 were observed (follow-up until 2018). Patients were considered to have FLD if they had at least two outpatient visits or at least one admission record with a diagnostic code of FLD. Patients with FLD were matched 1:1 by age, sex, comorbidities, and index year with control patients. Additionally, the FLD was further categorized into non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) groups. Multivariable Cox proportional hazards model was used to calculate the incidence rate and adjusted hazard ratio (aHR) of HZ for FLD and AFLD and for various age groups, sex and comorbidities. Cumulative incidence curve for HZ was plotted through the Kaplan–Meier method, and p-value was calculated using the log-rank test.

Results

After 1:1 propensity-score matching, each cohort comprised 62,418 patients. The FLD cohort was further divided into NAFLD and AFLD groups, which respectively comprised 55,709 and 6709 patients. The FLD cohort had a risk of HZ significantly higher than that of the control cohort (aHR = 1.06; p < 0.001). Additionally, the NAFLD group exhibited a significantly higher risk of HZ than did the AFLD group (aHR = 1.22; p < 0.001). Among patients without any comorbidities, those with FLD had a higher risk of HZ than did those without FLD (aHR = 1.14; p < 0.001).

Conclusion

Patients with FLD are at an increased risk of HZ development. Additionally, NAFLD is associated with a higher risk of HZ than AFLD. Therefore, patients with NAFLD should be informed of their increased risk of HZ.
Behavioral lateralization in bipolar disorders: a systematic review
Authors: Mundorf Annakarina , Borawski Jette , Ocklenburg Sebastian
Published: December 2023

Background

Bipolar disorder (BD) is often seen as a bridge between schizophrenia and depression in terms of symptomatology and etiology. Interestingly, hemispheric asymmetries as well as behavioral lateralization are shifted towards a tendency of left-side or mixed-side bias in schizophrenia whereas no shift is observed in subjects with depression. Given the role of BD with both, (hypo)manic and depressive episodes, investigating hemispheric asymmetries in subjects with BD is an interesting objective.

Method

A systematic review of studies including measures of behavioral lateralization in the form of handedness, footedness, eyedness, and language lateralization was performed resulting in 25 suitable studies.

Results

A broad variety of methods was used to assess behavioral lateralization, especially for eyedness, footedness, and language lateralization hindering the integration of results. Additionally, for hand preference, studies frequently used different cut-off scores and classification systems. Overall, studies do not support alteration in side preference in BD subjects. Studies focusing on differences in handedness demonstrate that subjects show equal rates of right- and non-right-handedness as the general population. Few studies focusing on manic episodes point towards increased left-side bias in ear and eye dominance, but the small sample sizes and conflicting results warrant further investigation.

Conclusion

The results reinforce that some disorders, such as BD, should not be treated as a homogenous group but sub-groups should be analyzed within the patient’s population. Particularly, clinical implications resulting from neuroimaging studies highlight the need to study hemispheric asymmetries given that they may be important to consider for brain stimulation protocols.
Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus
Authors: McElwain Colm J , Manna Samprikta , Musumeci Andrea , Sylvester Isaac , Rouchon Chloé , O'Callaghan Anne Marie , Ebad Mustafa Abdalla Bakhit , McCarthy Fergus P , McCarthy Cathal M
Published: December 2023

Context

Gestational diabetes mellitus (GDM) is a complex obstetric condition affecting localized glucose metabolism, resulting in systemic metabolic dysfunction.

Objective

This cross-sectional study aimed to explore visceral adipose tissue (VAT) as an integral contributor to GDM, focusing on elucidating the specific contribution of obesity and GDM pathology to maternal outcomes.

Methods

Fifty-six nulliparous pregnant women were recruited, including normal glucose tolerant (NGT) (n = 30) and GDM (n = 26) participants. Participants were subgrouped as nonobese (BMI <30 kg/m2) or obese (BMI ≥30 kg/m2). Metabolic markers in circulation, VAT, and placenta were determined. Morphological analysis of VAT and immunoblotting of the insulin signaling cascade were performed.

Results

GDM participants demonstrated hyperinsulinemia and elevated homeostatic model assessment for insulin resistance (HOMA-IR) scores relative to NGT participants. The GDM-obese subgroup had significant VAT adipocyte hypoplasia relative to NGT-nonobese tissue. GDM-obese VAT had significantly lower insulin receptor substrate (IRS)-2 expression, with elevated ser312 phosphorylation of IRS-1, relative to NGT-nonobese. GDM-obese participants had significantly elevated circulating leptin levels and placental adipsin secretion, while GDM-nonobese participants had elevated circulating adipsin levels with reduced placental adiponectin secretion.

Conclusion

These findings suggest that GDM-obese pregnancy is specifically characterized by inadequate VAT remodeling and dysfunctional molecular signaling, which contribute to insulin resistance and hinder metabolic health.
Dectin-2 Deficiency Promotes Proinflammatory Cytokine Release From Macrophages and Impairs Insulin Secretion
Authors: Fujita Masamichi , Miyazawa Takashi , Uchida Keiichiro , Uchida Naohiro , Haji Shojiro , Yano Seiichi , Iwahashi Norifusa , Hatayama Tomomi , Katsuhara Shunsuke , Nakamura Shintaro , Takeichi Yukina , Yokomoto-Umakoshi Maki , Miyachi Yasutaka , Sakamoto Ryuichi , Iwakura Yoichiro , Ogawa Yoshihiro
Published: December 2023

Pancreatic islet inflammation plays a crucial role in the etiology of type 2 diabetes (T2D). Macrophages residing in pancreatic islets have emerged as key players in islet inflammation. Macrophages express a plethora of innate immune receptors that bind to environmental and metabolic cues and integrate these signals to trigger an inflammatory response that contributes to the development of islet inflammation. One such receptor, Dectin-2, has been identified within pancreatic islets; however, its role in glucose metabolism remains largely unknown. Here we have demonstrated that mice lacking Dectin-2 exhibit local inflammation within islets, along with impaired insulin secretion and β-cell dysfunction. Our findings indicate that these effects are mediated by proinflammatory cytokines, such as interleukin (IL)-1α and IL-6, which are secreted by macrophages that have acquired an inflammatory phenotype because of the loss of Dectin-2. This study provides novel insights into the mechanisms underlying the role of Dectin-2 in the development of islet inflammation.
PERFIL CLÍNICO DOS USUÁRIOS COM DEMANDA EM SAÚDE MENTAL DE UMA UNIDADE DE SAÚDE DA FAMÍLIA DO MUNICÍPIO DE RONDONÓPOLIS-MT
Authors: Ferreira Giovanna de Freitas , Silva Thaynara Oliveira da , Felicetti Gabriela Caroline Laismann , Prado Bárbara Grassi
Published: December 2023

Introdução: Os transtornos mentais são manifestações psicopatológicas associadas a alterações de pensamentos, percepções, emoções e comportamentos que podem afetar as relações interpessoais e causar incapacidade de longa duração, afetando a qualidade de vida dos indivíduos e gerar ônus para a saúde pública. A saúde mental, por sua vez, constituindo o conceito ampliado de saúde, refere-se a um bem-estar biopsicossocial e é abrangida pela Atenção Primária à Saúde, que faz parte da Rede de Atenção Psicossocial. Objetivo: Caracterizar o perfil clínico e epidemiológico dos usuários com demanda em saúde mental assistidos em uma Unidade Saúde da Família no município de Rondonópolis, MT. Métodos: Trata-se de um estudo transversal e descritivo, realizado a partir da análise documental de dados secundários presentes em um banco de dados já existente de usuários desta Unidade de Saúde da Família. Resultados: Foram analisados 224 prontuários, dos quais 73% pertenciam à pacientes do sexo feminino. Em ambos os sexos, os diagnósticos mais prevalentes foram Transtorno Depressivo Maior (40,6%), Transtorno de Ansiedade Generalizada (38,4%) e Transtorno do sono (33,5%). Conclusões: Mediante a caracterização clínica e epidemiológica dos usuários com demanda em saúde mental, há a necessidade de planejar intervenções em saúde voltadas para a realidade local a fim de minimizar o sofrimento da população adscrita.
Assessment and consequences of pesticides on the health of the population of Mala
Authors: Esteves Pairazaman Ambrocio Teodoro , TARAZONA TINEO JACKELINE FABIOLA , ESTEVES PAIRAZAMAN MANUEL EMILIANO , LEÓN GOMEZ RODOLFO , Trujillo Roman Ramiro , Escalante Cárdenas Mauricio Raúl , Jara Miranda Robert , Hinojosa Benavides Rene Antonio , Peso Cárdenas German Gabriel
Published: December 2023

Background In Peru, the use of pesticides is very common in the agricultural sector to protect crop varieties, which in turn causes damage to human health due to their toxic effects. The objective of this study was to assess the consequences of pesticides on the health of the population of Mala, Peru Methods This was a non-experimental, descriptive and cross-sectional study. A total of 315 inhabitants of the District of Mala between the ages of 18 and 50 years were evaluated. The method used was a survey and the data collection instrument was a questionnaire. Results The pesticide most frequently used by farmers was Malathion (43.5%), followed by Clopyrifos (17.5%), Dicrotophos (14.6%) and finally Carbofuran (14%). The most frequent main symptoms of pesticide use were nausea (17.5%) and salivation (10.2%). Exposure time ranged from 30 minutes (23.8%) to 2 hours (16.8%). Conclusions Malathion (43.5%) was found to be the most commonly used pesticide by farmers in Mala and the main symptom of pesticide use was headache (55.9%).
Case Report: Case report: Rapidly progressing tooth wear dominated by intrinsic and extrinsic erosion
Authors: Marchan Shivaughn , Ollivierra Estévan , Diaz Alexa , Santo Rochard
Published: December 2023

Tooth wear is multi-factorial presenting as a combination of abrasion, attrition, and erosion. This case report represents a case of combined tooth wear in a 46-year-old Indo-Trinidadian male, with a predominant erosive component with both the clinical signs and features of intrinsic and extrinsic erosion. This patient case is unique since the wear predominated by dental erosion has occurred rapidly evidenced by the physical clinical appearance of a lack of compensation and the upper left premolars and molars relatively unaffected by the overall effects of tooth wear. This lack of compensation, where opposing teeth have not supra-erupted to maintain inter-arch stability, and the maintenance of occlusal vertical dimension on the left due to the non-worn posterior maxillary teeth, provides the benefit of simplifying subsequent restorative management. The medical and diet history corroborates the diagnoses of intrinsic and extrinsic erosion respectively. Complications noted with rapid tooth wear, such as dentine sensitivity and pulpal necrosis are known sequelae of tooth wear however the patient presented in this case report shows a concomitant high caries experience and poor oral hygiene. Cases such as the one presented here require not only comprehensive dental management, utilizing a restorative approach but also medical referral for confirmation of a diagnosis and management of gastroesophageal reflux disease. Inherent to the management of this patient should be a multidisciplinary medical and dental approach, with confirmation and management of the cause of the intrinsic erosion as well as restorative dental management, together with dietary counseling to mitigate the effect of intrinsic and extrinsic sources of acid on dental hard tissue. A key lesson learned from this case is the importance of history and targeted questioning when trying to determine the cause of tooth wear dominated by intrinsic and extrinsic erosion.
Türk Kültüründe Yönetsel Etik Olgusunun Kritik Kodları: Kutadgu Bilig Üzerinden Okumalar
Authors: Taşgit Yunus Emre , Dağlı Zülkif , Biriktirir Livanur
Published: December 2023

The acceptability of the behaviors exhibited in the administrative sense depends on the social value judgments. Value judgments, in a sense, express cultural ethical codes. What behavior is meaningful when, how and why? The answers to the question reveal the ethical codes of a society in the cultural context. In this research, it is aimed to draw a conceptual portrait on the ethics value judgments related to the management phenomenon in Turkish culture. For this purpose, the Kutagu Bilig work of Yusuf Has Hacib, which is the first policy book of the Turks, has been examined and the author’s perspective and thoughts on ethical and unethical behaviors in the administrative sense have been tried to be described. Qualitative data analysis techniques were used to obtain the findings. In this context, 11 ethical behaviors and 9 unethical behaviors in managerial sense were determined by adhering to Yusuf Has Hacib’s use of concepts about management and the methodological features of the work. Although the findings have both exploratory and confirmatory qualities, it has been seen that the majority of the themes offer a very different perspective in terms of content, although there are names similar to the concepts in the existing literature. Therefore, it can be argued that the study provides complementary and enriching contributions to the literature.
Etik ve Hukuk Boyutuyla Tezden Üretilen Yayınlarda Haksız Yazarlık
Authors: Kalkan Nimet , Karaaslan Pelin
Published: December 2023

The research examines the issue of unfair authorship, considered within the scope of scientific publication ethics and the law on intellectual property rights, by analysing the order of the authors of publications derived from the dissertations. To this tendency, tags of one hundred and sixty-one dissertations published in 2015-2019 by the De- partment of Business Administration-Management & Organization categorized by document analysis. The publications derived from those are determined using certain search criteria. In the last stage, descriptive statistics applied by SPSS to see the ethical reflection of the publications. Results show that unethical authorship is approximately 17%. The doctoral students are not the first author though they are the first carrier of the research. Out of 30 universities, 11 had unfair authorship practices and clustered mainly in 5. Discussing results with the gender of the authors and supervisors, titles, and universities show that the subject needs to consider both personal ethical values and the organizational culture. In this respect, the research will practically contribute to raising awareness about ethical violations, developing mechanisms for preventing unethical practices, and shed light on future studies which investigate the causes of unethical situations.
Örgütsel Kutsallaştırma: Ölçek Geliştirme ve Geçerlilik
Authors: Şengüllendi Muhammet Fatih , Şehitoğlu Yasin
Published: December 2023

This study aims to develop the Organizational Sacralization Scale, organizational sacralization involving how the concept of the sacred, the existence of which dates back to the earliest periods of humanity, is currently reflected in organizations. This study first tests the content validity of the Organizational Sacralization Scale. The next stage is the pilot study phase, in which validity and reliability tests are conducted for the scale using data obtained from 116 white-collar employees. The next stage tests the construct validity of the scale within the scope of data obtained from 215 white-collar employees. The research results show the concept of organizational sacralization to be a scientifically measurable and psychometrically valid and reliable concept consisting of 13 items in three subdimensions: seeking meaning, providing meaning, and legitimating meaning.
Yapay Zekânın Bilimsel Yayın Amaçlı Kullanımına İlişkin Etik Kaygılar: Sistematik Bir Yazın İncelemesi
Authors: Uyan Umut
Published: December 2023

Although artificial intelligence (AI) is a relatively new technology, it claims to change and transform our business practices. This novel technology, which offers tools that are easy-to-use, fast, and tailor-made outputs in terms of efficiency and productivity, is also becoming more prevalent in higher education. Nonetheless, some ethical issues need to be addressed regarding the use of these technologies for both education and research purposes. This study, designed as a systematic literature review, aims to reveal the ethical concerns regarding such technologies used in scientific publishing activities. Five distinct themes have emerged echoing ethical concerns regarding AI use in scientific publications: Artificially guided research, the illusion of velocity, bias, data quality, and ready-made science. The study serves as a wake-up call to researchers to approach such technologies not only from a cost-benefit perspec- tive, but also to examine potential ethical considerations. Among the pioneering studies on AI usage for scientific publication in higher education, this study will add to the body of knowledge.
The effect of nurse-led interventions on non-adherence to dietary and fluid restrictions among adults receiving haemodialysis: a randomised controlled trial
Authors: VR Vijay , Kang Harmeet Kaur
Published: December 2023

This study aimed to examine the effect of nurse-led interventions on non-adherence to dietary and fluid restrictions among adults receiving haemodialysis. A randomised, controlled trial design was used for this study. While the interventional group received nurse-led interventions in addition to routine care, the control group received only standard care. The study found that, in the intervention group, the number of non-adherence days to diet (p=0.001) and fluid (p=0.001) restrictions have significantly decreased after the interventions. Furthermore, the between-group analysis depicted a statistically significant reduction of non-adherence days in the intervention group compared to the control group at week 10 for both diet (p=0.018) and fluid (p=0.003). However, the objective adherence to diet and fluid restrictions, based on the composite scale, showed no statistically significant improvement in the proportion of adherence in the intervention group after the interventions.
Health and social care research from the frontline: perspectives from care home staff
Authors: Kelly Marlene , Allison Emily , Micklewright Kerry
Published: December 2023

Marlene Kelly and Emily Allison reflect on their forays into the world of health and social care research from their ‘expert-by-experience’ perspective.
A modified Delphi consensus statement on patellar instability: part II
Authors: Hurley Eoghan T. , Sherman Seth L. , Chahla Jorge , Gursoy Safa , Alaia Michael J. , Tanaka Miho J. , Pace J. L. , Jazrawi Laith M.
Published: December 2023

Aims

The aim of this study was to establish consensus statements on medial patellofemoral ligament (MPFL) reconstruction, anteromedialization tibial tubercle osteotomy, trochleoplasty, and rehabilitation and return to sporting activity in patients with patellar instability, using the modified Delphi process.

Methods

This was the second part of a study dealing with these aspects of management in these patients. As in part I, a total of 60 surgeons from 11 countries contributed to the development of consensus statements based on their expertise in this area. They were assigned to one of seven working groups defined by subtopics of interest. Consensus was defined as achieving between 80% and 89% agreement, strong consensus was defined as between 90% and 99% agreement, and 100% agreement was considered unanimous.

Results

Of 41 questions and statements on patellar instability, none achieved unanimous consensus, 19 achieved strong consensus, 15 achieved consensus, and seven did not achieve consensus.

Conclusion

Most statements reached some degree of consensus, without any achieving unanimous consensus. There was no consensus on the use of anchors in MPFL reconstruction, and the order of fixation of the graft (patella first versus femur first). There was also no consensus on the indications for trochleoplasty or its effect on the viability of the cartilage after elevation of the osteochondral flap. There was also no consensus on postoperative immobilization or weightbearing, or whether paediatric patients should avoid an early return to sport.

Cite this article: Bone Joint J 2023;105-B(12):1265–1270.
A new local flap technique for closing long-axis skin defects: the cyclist flap procedure
Authors: Öcük Ö
Published: December 2023

Background

Local flaps are commonly used during the treatment of skin tissue defects. Although there are many available procedures for the closure of triangular, circular and rhomboid-shaped defects, long-axis elliptical skin defects lack treatment options. To address this problem, a new local flap design called the cyclist flap procedure (CFP) was developed, so called because it resembles the silhouette of a person riding a bicycle.

Methods

The CFP was performed in 29 patients aged 9–81 years in 2021–2022. The defects were localised in the sacral region (1), upper extremities (3), lower extremities (3), and head and neck regions (22). Closures of skin defects due to pressure ulcers (one patient) and after tumour excision (28 patients) were performed, and the patients were followed up for 12–20 months.

Results

Only minor complications were observed in two patients. During follow-ups, no secondary surgery was required due to dog-ear, trapdoor, recurrence or revision. Furthermore, the aesthetic results related to the skin lines and scar size were acceptable.

Conclusion

The CFP is a new, easy-to-apply and advantageous procedure for the closure of long-axis elliptical and oval skin tissue defects.
‘Testicular masquerade’: a case report of testicular malignancy with persistent Müllerian duct syndrome and transverse testicular ectopia
Authors: Barki D , Manayath N , Vatsa BS , Venkatanarasimhan N S , Vishnuvardhana G V , Achar S , Bhat B
Published: December 2023

Persistent Müllerian duct syndrome (PMDS) is a rare sexual development disorder. It is even more rarely associated with transverse testicular ectopia (TTE), a rare form of testicular ectopia, in which both testes descend through a single inguinal canal and are present in the same hemiscrotum. PMDS with TTE is associated with 18%–33% malignant transformation. Here we report the case of a 48-year-old man who presented with a large right inguinoscrotal swelling and on evaluation was found to have a large right testicular mass with complete right inguinal hernia, undescended left testis and a central abdominal mass. On evaluation with contrast-enhanced computed tomography abdomen and pelvis and image-guided biopsy he was diagnosed with mixed germ cell tumour of the right testis (predominantly a seminoma) with a retroperitoneal nodal mass and absent left testis, for which he received chemotherapy. Post-chemotherapy he underwent surgery and was diagnosed intraoperatively with PMDS along with TTE and testicular malignancy arising from the ectopic left testis. Postoperative recovery and follow-up were uneventful. Most cases of PMDS are diagnosed early in life. They present clinically with unilateral or bilateral undescended testis with inguinal hernia. In adults, PMDS is usually associated with male infertility. However, TTE is associated with an increased risk of testicular tumours if undiagnosed until adulthood. In adults PMDS with TTE is usually an intraoperative finding and is commonly associated with malignancy in the ectopic/undescended testis.
Morphing concepts in the field of rotorcraft
Authors: FERARU Dorin Madalin , LARCO Ciprian Marius , GRIGORIE Teodor Lucian
Published: December 2023

Drawing inspiration from avian creatures, aeronautical engineers strive to create an ideal wing design that can seamlessly perform in various flight conditions. Avian creatures, as well as bats and other flying organisms, exhibit a striking aptitude to adjust the lift produced by their wings, displaying the capacity to repeatedly tailor their wing configurations to match specific environmental conditions. An example of this is when their wings are tightly tucked during dives for hunting, or fully extended during gliding to conserve energy. Moreover, these organisms can manipulate the curvature and twist of their wings to maintain precise control over their aerial maneuvers. In contrast, engineers in the aircraft industry continue to rely on the standard, robust and structured “one-point design” approach, which remains the most practical and feasible method to apply. Nonetheless, advancements in technology have emerged to address long-standing challenges in wing manufacturing that were previously deemed insurmountable. This convergence of different technologies has given significant momentum and recognition to the field of “morphing discipline”. When considering an aircraft, shape changes primarily relate to the wing of a fixed-wing aircraft or the blade of a rotorcraft. The concept of achieving a "smooth" shape change stems from the crucial need for drag reduction and improved flow quality, resulting in improved overall performance. The state-of-the-art morphing concepts applied to rotorcrafts comprise a wide range of investigations aimed at improving performance. Looking ahead, the primary challenge for morphing technology will be to persuade the industry of its tangible benefits. This encompasses enhanced aerodynamic efficiency, minimized installation footprint when contrasted with conventional control surface mechanisms, reduced overall weight, and an equivalent standard of safety. This research provides an overview of the current development of different control devices and explores the impact of previous and continuous research endeavors in this field. Numerous ideas for managing airflow have been explored with the aim of enhancing the performance abilities of rotary-wing aircraft. These include active morphing in rotorcraft such as leading edge slats, trailing edge flaps, and passive morphing in rotorcraft such as variable rpm rotorcraft. The aim of these blade modifications is to achieve various desired effects such as increasing the maximum lift coefficient, reducing drag, and minimizing vibratory loads. Convincing the industry of these advantages will play a crucial role in shaping the future of morphing technology.
Deep neural network modeling for CFD simulation of drone bioinspired morphing wings
Authors: MARIN Florin Bogdan , BURUIANA Daniela Laura , GHISMAN Viorica , MARIN Mihaela
Published: December 2023

In this paper we present a deep neural network modelling using Computational Fluid Dynamics (CFD) simulations data in order to optimize control of bioinspired morphing wings of a drone. Drones flight needs to consider variation in aerodynamic conditions that cannot all be optimized using a fixed aerodynamic profile. Nature solves this issue as birds are changing continuously the shape of their wings depending of the aerodynamic current requirements. One important issue for fixed wing drone is the landing as it is unable to control and most of the time consequences are some damages at the nose. An optimized shape of the wing at landing will avoid this situation. Another issue is that wings with a maximum surface are sensitive to stronger head winds; while wings with a small surface allowing the drone to fly faster. A wing with a morphing surface could adapt its aerial surface to optimize aerodynamic performance to specific flight situations. A morphing wing needs to be controlled in an optimized manner taking into account current aerodynamics parameters. Predicting optimized positions of the wing needs to consider (CFD) prior simulation parameters. The scenarios for flight require an important number of CFD simulation to address different conditions and geometric shapes. We compare in this paper neural network architecture suitable to predict wing shape according to current conditions. Deep neural network (DNN) is trained using data resulted out of CFD simulations to estimate flight conditions.