PROTRACTED BACTERIAL BRONCHITIS IN CHILDREN: ETIOLOGY, CLINICAL OPTIONS, X-RAY SEMIOTICS, COMORBIDITY
Authors:   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia, Makarenko E.V. , Ovsyannikov D.Yu. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia,   Moscow City Children's Infectious Diseases Hospital No. 6 of the Moscow Department of Healthcare, Moscow, Russia,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Karpenko M.A. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia,   Moscow City Children's Infectious Diseases Hospital No. 6 of the Moscow Department of Healthcare, Moscow, Russia, Illarionova T.Yu. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia, Alekseeva O.V. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia, Kantemirova M.G. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia, Grigoriadis N.K. ,   Moscow City Children's Infectious Diseases Hospital No. 6 of the Moscow Department of Healthcare, Moscow, Russia, Tsverava A.G. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Berejansky P.V. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Gitinov Sh.A. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia,   Moscow City Children's Infectious Diseases Hospital No. 6 of the Moscow Department of Healthcare, Moscow, Russia, Gorev V.V. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Smirnova L.V. ,   Yaroslavl City Central Hospital, Yaroslavl, Russia, Vybornov A.V. ,   Yaroslavl City Central Hospital, Yaroslavl, Russia, Boitsova E.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Khaled M. ,   KindCare Medical Center, Dubai, Emirate of Dubai, United Arab Emirates
Published: March 2023

Cough in childhood is one of the most common reasons for and symptoms when contacting a pediatric physician. Chronic (lasting over four weeks) wet/productive cough is of particular diagnostic difficulty when it is caused by protracted bacterial bronchitis (PBB). The purpose of this research was to study the etiology, clinical options, X-ray semiotics and comorbid diseases in children with PBB. Materials and methods used: clinical observation and analysis of case histories of 76 children aged starting 4.5 months up to 16 years old with PBB were carried out from Mar. 2017 to Jun. 2022. Research methods: microbiological, radiography and computed tomography (CT) of the chest, bronchoscopy, allergy diagnostics, spirometry. The design of the study was as follows: multicentre, non-comparative, open-label, non-randomized, ambispective pilot study. Results: PBB is more common in boys (57%) aged 3 to 7 y/o (59%) and is rare in infancy (7%). The majority of patients met the clinical definition of PBB (86%) and responded to 2 weeks of antibiotic therapy with amoxicillin/clavulanate (78%). The microbiological diagnosis of PBB was confirmed in 14% of children based on bronchoscopy with microbiological examination of bronchoalveolar lavage (BAL) fluid or sputum examination. The most common pathogens encountered in BAL, sputum and discharge from the nasopharynx, oropharynx are as follows: S. aureus, M. catarrhalis, H. influenzae and S. pneumoniae. The chest X-ray showed bronchitis changes; the chest CT, which was performed in 10 patients, had showed thickening of the bronchial walls. Bronchial dilatation was found in 3 children, bronchiectasis was found in a single patient. Bronchial asthma was comorbid with PBB, occurred in 22% of PBB cases. Conclusion: it is necessary for a pediatric physician to keep PBB in mind as one of the reasons for chronic wet/productive cough in children in order to correctly and timely diagnose the disease and prescribe its adequate treatment.