bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute respiratory infections among individuals seeking outpatient care in the states of Washington and Michigan by pregnancy status, 2011–2016
Authors: Frivold Collrane , McCulloch Denise J. , Ekici Seda , Martin Emily T. , Jackson Michael L. , Chu Helen Y.
Published: December 2023

Background

Acute respiratory infections (ARIs) during pregnancy are associated with poor maternal and fetal outcomes.

Methods

Using U.S. Flu Vaccine Effectiveness Network data (2011–2016) from Washington and Michigan, we tested for respiratory viruses among pregnant and non‐pregnant outpatients matched on age, site, and season (n = 191).

Results

Among all participants, detection of human coronaviruses and rhinovirus was common. We also observed differences in virus detection by pregnancy status; human coronaviruses and respiratory syncytial virus (RSV) were detected more frequently among pregnant and non‐pregnant participants, respectively.

Conclusions

The role of respiratory viruses in maternal ARI morbidity should be further characterized to inform implementation of prevention interventions including maternal vaccines.
Leadership practices that enable healthful cultures in clinical practice: A realist evaluation
Authors: Dickson Caroline A. W. , Merrell Joy , McIlfatrick Sonja , Westcott Liz , Gleeson Nigel , McCormack Brendan
Published: December 2023

Aim

To generate, test and refine programme theories that emerged from a rapid realist review investigating practising UK Nurses' and Midwives' experiences of effective leadership strategies during the COVID‐19 pandemic.

Background

The realist review of literature generated six tentative theories of healthful leadership practices reflecting, working with people's beliefs and values; being facilitative; multiple means of communication and; practical support. The review yielded little insight into the actual impact of the leadership approaches advocated.

Methods

A realist study, informed by person‐centredness using mixed‐methods. Online survey (n = 328) and semi‐structured interviews (n = 14) of nurses and midwives across the UK in different career positions/specialities. Quantitative data analysed using descriptive statistics and exploratory factor analysis. Framework analysis for qualitative data using context (C), mechanism (M), outcome (O) configurations of the tentative theories.

Results

Three refined theories were identified concerning: Visibility and availability; embodying values and; knowing self. Healthful leadership practices are only achievable within organisational cultures that privilege well‐being.

Conclusions

Leaders should intentionally adopt practices that promote well‐being. ‘Knowing self’ as a leader, coaching and mentoring practice development is important for leadership development.

Implications for Clinical Practice

Nurses who feel valued, heard, cared for and safe are more likely to remain in clinical practice. Job satisfaction and being motivated to practice with confidence and competence will impact positively on patient outcomes.

Impact

The study addresses the role of leadership in developing healthful workplace cultures. The main findings were six leadership practices that promote healthful cultures. The research will have an impact on strategic and clinical leaders, nurses and midwives.

Reporting Method

This study used EQUATOR checklist, RAMASES II as reporting standards for realist evaluations.

Patient or Public Contribution

No patient or public contribution.
Measuring the gender wealth gap in South Africa using individual‐level data
Authors: Casale Daniela , Oyenubi Adeola
Published: December 2023

Despite widespread recognition that assets are important for economic wellbeing and women's empowerment, there is limited research on gender wealth gaps in either developed or developing countries. This is largely due to the lack of individual‐level data on wealth or net worth (i.e. the value of assets less debt). Most surveys that collect information on wealth do so at the household level with only one member responding on behalf of the household, even though most assets and debts are held by individuals. In this paper, we measure the gender wealth gap for South Africa using unique individual‐level data collected in the 2017 National Income Dynamics Survey, a representative household survey covering roughly 22,000 adults. We find that men and women hold different types of assets and debt and that there is a substantial gender gap in the monetary value of their net worth, greater than the gender earnings gap recorded in the same year. In our discussion, we reflect on some of the key challenges in measuring wealth as well as remaining gaps in data collection and research.
Evaluation of the use of intranasal atipamezole to reverse the sedative effects of xylazine in dogs
Authors: Focken Alex P. , Woodsworth Jordan M. , Loewen Jennifer M.
Published: December 2023

Objective

To assess the ability of intranasal atipamezole to reverse sedative effects of xylazine in dogs.

Design

Prospective proof‐of‐concept study.

Setting

University research laboratory.

Animal

Six healthy, staff‐owned dogs.

Interventions

Dogs were sedated with 1.1 mg/kg of xylazine intravenously. The sedation score of each dog was recorded every 5 minutes until they achieved a sedation score of >13/21 for 3 readings. Once achieved, 0.3 mg/kg of atipamezole was administered intranasally using a mucosal atomization device. Sedation scores continued to be recorded every 5 minutes until successful reversal was achieved (<4/21).

Measurements and Main Results

Average times to standing and normal wakefulness after administration of intranasal atipamezole were 6 minutes, 30 seconds and 7 minutes, 20 seconds, respectively.

Conclusions

Intranasal atipamezole successfully reversed the sedation effects of xylazine. The findings of this study provide justification for future controlled prospective studies into the potential use of intranasal atipamezole in a variety of settings including exposure to xylazine in operational canines as well as bioavailability studies for optimal dosing.
Towards A Scientific Methodology for Arab Investigative Journalism: An in-depth Analysis of Interviews with Ten Arab Journalists
Authors: Almabrouk Khalil , Adnan Hamedi , Sarmiti Nor Zaliza
Published: December 2023

This study aimed to build an applied model on the methodology of investigative journalism in the Arab world. To achieve this goal, this study followed the methodology of in-depth analysis of interviews via e-mail with ten Arab journalists interested in investigative journalism, whether those who practiced investigative reporting or received training in this field. This study is significant because it draws the attention of researchers and academics to the need for adopting a scientific methodology for investigative journalism. In addition, it could be turned into a part of a broader research track to develop Arab investigative journalism methodology. Based on the analysis of the interviewees’ answers, these steps can be listed as follows: Finding an original idea, writing the hypothesis, preparing a solid systematic action plan to prove the hypothesis of the investigation, conducting field work, producing the investigative report whether written or televised, and finally publishing the report.
Concussion Risk and Recovery in Athletes With Psychostimulant-Treated Attention-Deficit/Hyperactivity Disorder: Findings From the NCAA-DOD CARE Consortium
Authors: Coffman Colt A. , Gunn Brett S. , Pasquina Paul F. , McCrea Michael A. , McAllister Thomas W. , Broglio Steven P. , Moore Robert D. , Pontifex Matthew B.
Published: December 2023

The aim of the present study was to examine the effects of attention–deficit/hyperactivity disorder (ADHD) –related psychostimulant use in the context of concussion risk and symptom recovery. Data were obtained from the National Collegiate Athletic Association Department of Defense Grand Alliance Concussion Assessment, Research, and Education (NCAA-DOD CARE) Consortium from 2014 to 2017. Relative to individuals without diagnosed ADHD (i.e., control), both ADHD diagnosis and the combination of ADHD diagnosis and psychostimulant use were associated with a greater risk of incurring a concussive injury. Following a concussive injury, ADHD diagnosis was associated with longer symptom recovery time relative to the control group. However, individuals with ADHD who use psychostimulants did not take longer to resolve symptoms than controls, suggesting that psychostimulants may have a positive influence on recovery. Regardless of time point, ADHD diagnosis was associated with an elevated number of concussion-related symptoms; however, this effect appears mitigated by having used ADHD-related psychostimulants.
Adapted Physical Activity Scholarship: Evolving From Corrective to Inclusion and Anti-Ableist
Authors: DePauw Karen P.
Published: December 2023

Kinesiology and adapted physical activity (APA) share a common history rooted in the medical model approach to physical activity, movement, and the human body. The evolution of APA was influenced by these early roots and later by special-education legislation, sensory-motor perspectives, inclusion movement, and the disability-rights movement. Originally identified as adapted physical education, APA emerged as a professional field and an academic discipline. Since the 1950s, the research and scholarship has increased and cuts across the specialization areas (subdisciplines) of kinesiology. The multidisciplinary nature of APA scholarship has also reached beyond the discipline of kinesiology informed by disability studies and sociology. Reflection about APA and kinesiology reveals the ableist nature of the medical model, which informed early professional practice and scholarship. Thus, it is critical that APA and kinesiology engage in anti-ableist scholarship to better understand human physical activity and movement inclusive of individuals with disabilities.
Self-enhancing sono-inks enable deep-penetration acoustic volumetric printing
Authors: Kuang Xiao , Rong Qiangzhou , Belal Saud , Vu Tri , López López Alice M. , Wang Nanchao , Arıcan Mehmet Onur , Garciamendez-Mijares Carlos Ezio , Chen Maomao , Yao Junjie , Zhang Yu Shrike
Published: December 2023

Volumetric printing, an emerging additive manufacturing technique, builds objects with enhanced printing speed and surface quality by forgoing the stepwise ink-renewal step. Existing volumetric printing techniques almost exclusively rely on light energy to trigger photopolymerization in transparent inks, limiting material choices and build sizes. We report a self-enhancing sonicated ink (or sono-ink) design and corresponding focused-ultrasound writing technique for deep-penetration acoustic volumetric printing (DAVP). We used experiments and acoustic modeling to study the frequency and scanning rate–dependent acoustic printing behaviors. DAVP achieves the key features of low acoustic streaming, rapid sonothermal polymerization, and large printing depth, enabling the printing of volumetric hydrogels and nanocomposites with various shapes regardless of their optical properties. DAVP also allows printing at centimeter depths through biological tissues, paving the way toward minimally invasive medicine.
In Science Journals
Authors: Lopez Bianca , Smith Keith T. , Seale Madeleine , Vignieri Sacha , Hurtley Stella M. , Yeston Jake S. , Ferrarelli Leslie K. , Charneski Catherine , Lempriere Sarah A. , Alderton Gemma , Nusinovich Yevgeniya , Smith H. Jesse , Scanlon Seth Thomas , Stajic Jelena , Lavine Marc S. , Isles Hannah M. , Oyen Michelle L.
Published: December 2023

Highlights from the
Science
family of journals
Low-Molecular Thiols as a Factor Improving the Sensitivity of Escherichia coli Mutants with Impaired ADP–Heptose Synthesis to Antibiotics
Authors: Seregina T. A. , Petrushanko I. Yu. , Zaripov P. I. , Kuleshova Yu. D. , Lobanov K. V. , Shakulov R. S. , Mitkevich V. A. , Makarov A. A. , Mironov A. S.
Published: December 2023

Abstract—Low molecular-weight thiols as glutathione and cysteine are an important part of the cell’s redox regulation system. Previously, we have shown that inactivation of ADP-heptose synthesis in Escherichiacoli with a gmhA deletion induces the oxidative stress. It is accompanied by rearrangement of thiol homeostasis and increased sensitivity to antibiotics. In our study, we found that restriction of cysteine metabolism (∆cysB and ∆cysE) and inhibition of glutathione synthesis (∆gshAB) lead to a decrease in the sensitivity of the ∆gmhA mutant to antibiotics but not to its expected increase. At the same time, blocking of the export of cysteine (∆eamA) or increasing import (Ptet-tcyP) into cells of the oxidized form of cysteine–cystine leads to an even greater increase in the sensitivity of gmhA-deleted cells to antibiotics. In addition, there is no correlation between the cytotoxic effect of antibiotics and the level of reactive oxygen species (ROS), the total pool of thiols, or the viability of the initial cell population. However, a correlation between the sensitivity to antibiotics and the level of oxidized glutathione in cells was found in our study. Apparently, a decrease in the content of low-molecular-weight thiols saves NADPH equivalents and limits the processes of protein redox modification. This leads to increasing of resistance of the ∆gmhA strain to antibiotics. An increase in low-molecular-weight thiols levels requires a greater expenditure of cell resources, leads to an increase in oxidized glutathione and induces to greater increase in sensitivity of the ∆gmhA strain to antibiotics.
Dinityrosyl Iron Complexes with Thiol-Containing Ligands as a Functionally Active “Working Form” of Nitric Oxide System in Living Organisms: A Review
Authors: Vanin A. F.
Published: December 2023

Experimental data were summarized to assume that dinitrosyl iron complexes (DNICs) with thiol-containing ligands are an endogenous “working form” of the nitric oxide (NO) system in living organisms. DNICs can function as donors of both neutral NO molecules, which are responsible for positive regulatory effects of the NO system on various physiological and biochemical processes in humans and animals, and nitrosonium cations (NO+), which are responsible mostly for negative cytotoxic activity of the system. Special attention is paid to the finding that DNICs, especially in combination with dithiocarbamate derivatives, suppress SARS-CoV-2 infection in Syrian hamsters.
Stabilization of Steady Rotations of a Spherical Robot on a Vibrating Base Using Feedback
Authors: Kilin Alexander A. , Ivanova Tatiana B. , Pivovarova Elena N.
Published: December 2023

This paper treats the problem of a spherical robot with an axisymmetric pendulum drive
rolling without slipping on a vibrating plane. The main purpose of the paper is
to investigate the stabilization of the upper vertical rotations of the pendulum
using feedback (additional control action). For the chosen type of feedback,
regions of asymptotic stability of the upper vertical rotations of the pendulum are constructed
and possible bifurcations are analyzed. Special attention is also given to the question of
the stability of periodic solutions arising as the vertical rotations lose stability.
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
Authors: de Berny Quentin , Saint-Jacques Camille , Santin Aline , Mattioni Sarah , Steichen Olivier , Chieze Rémi , Frochot Vincent , Letavernier Emmanuel , Lionnet François , Haymann Jean-Philippe
Published: December 2023

The urine concentration impairment in sickle cell anemia is an osmotic diuresis related to an impaired renal medullary gradient leading to an ADH plateau effect. The fasting plasma ADH was high in the context of a basic state of close-to-maximal urine concentration probably driven by short nephrons maintaining a cortex-outer medullary gradient (about 400 milliosmoles). The patients had a low daily osmoles intake without evidence of thirst dysregulation so no one experienced polyuria.
External Validation of SAFE Score to Predict Atrial Fibrillation Diagnosis after Ischemic Stroke: A Retrospective Multicenter Study
Authors: Quesada López Miguel , Amaya Pascasio Laura , Blanco Madera Sara , Pagola Jorge , Vidal de Francisco Diana , de Celis Ruiz Elena , Villegas Rodríguez Inmaculada , Carneado-Ruiz Joaquín , García-Carmona Juan Antonio , García Torrecillas Juan Manuel , López Ferreiro Ana , Elosua Bayes Iker , Rigual Bobillo Ricardo Jaime , López López María Isabel , Esain González Íñigo , Ortega Ortega María Dolores , Blanco Ruiz Marina , Pérez Ortega Irene , Lázaro Hernández Carlos , Fuentes Gimeno Blanca , Arjona Padillo Antonio , Martínez Sánchez Patricia
Published: December 2023

Introduction. The screening for atrial fibrillation (AF) scale (SAFE score) was recently developed to provide a prediction of the diagnosis of AF after an ischemic stroke. It includes 7 items:

a
g
e
≥
65

years, bronchopathy, thyroid disease, cortical location of stroke, intracranial large vessel occlusion, NT-ProBNP ≥250 pg/mL, and left atrial enlargement. In the internal validation, a good performance was obtained, with an

A
U
C
=
0.88

(95% CI 0.84-0.91) and sensitivity and specificity of 83% and 80%, respectively, for

s
c
o
r
e
s
≥
5

. The aim of this study is the external validation of the SAFE score in a multicenter cohort. Methods. A retrospective multicenter study, including consecutive patients with ischemic stroke or transient ischemic attack between 2020 and 2022 with at least 24 hours of cardiac monitoring. Patients with previous AF or AF diagnosed on admission ECG were excluded. Results. Overall, 395 patients were recruited for analysis. The SAFE score obtained an

A
U
C
=
0.822

(95% CI 0.778-0.866) with a sensitivity of 87.2%, a specificity of 65.4%, a positive predictive value of 44.1%, and a negative predictive value of 94.3% for a SAFE

s
c
o
r
e
≥
5

, with no significant gender differences. Calibration analysis in the external cohort showed an absence of significant differences between the observed values and those predicted by the model (Hosmer-Lemeshow’s test 0.089). Conclusions. The SAFE score showed adequate discriminative ability and calibration, so its external validation is justified. Further validations in other external cohorts or specific subpopulations of stroke patients might be required.
Effects of Recycled Expanded Polystyrene Beads on the Mechanical and Physical Properties of Cement-Stabilized Compressed Earth Bricks
Authors: Kougoum Géraldine Gouafo , Tatchum Ulrich Giresse Defo , Koungang Bernard Morino Ganou , Ndapeu Dieunedort , Tchinda René
Published: December 2023

Nowadays, research on environmentally friendly materials has become a significant challenge in the field of civil engineering. In this study, stabilized compressed earth bricks (CEBs) incorporating recycled expanded polystyrene (EPS) beads were studied with the aim of enhancing the development of green constructions. The mass contents of recycled EPS in CEB formulated at a compaction pressure of 5 MPa are 0%, 0.25%, 0.5%, 0.75%, and 1% relative to the mass of the soil, while cement type CEM I 32.5, as a stabilizer, constituted 8% by mass. Characterization was carried out by determining densities, dry and wet compressive strength, flexural strength, total water absorption, and capillarity. Sample properties were found to be strongly influenced by the percentage of recycled EPS. Increasing the EPS aggregate content led to a reduction in compressive strength in both wet and dry conditions. Samples with 0.5% EPS and 8% cement offered better physical and mechanical performance. Samples containing EPS had relatively low water absorption, which would contribute to good durability. These CEBs comply with the wall construction requirements for two-story dwellings. This study also demonstrates the potential use of this recycled material in the construction industry.
Safety and Efficacy of Hybrid Surgery in Chronic Internal Carotid Artery Occlusion: A Systematic Review and Meta-Analysis
Authors: Tan Guanping , Wang Jing , Xing Wenli , He Zhaohui
Published: December 2023

Introduction: Chronic internal carotid artery occlusion (CICAO) is a common cause of stroke and ischemia recurrence. An increasing number of reports have highlighted the potential of hybrid surgery for treating CICAO. There are few studies, specifically nonrandomized controlled trials, on the safety and effectiveness of hybrid surgery for the treatment of CICAO, so in this study, we hypothesized that hybrid surgery would be safe, have an acceptable complication rate and a high success rate. Methods: MEDLINE, Embase, Cochrane Library, and Web of Science databases were searched for relevant studies published up to January 30, 2023. The primary endpoint was recanalization rates of occluded vessels, and the secondary endpoint was perioperative death and procedure-related complications. Subgroup analysis focused on the recanalization rates of endovascular intervention (EI) and hybrid surgery, as well as the rates of recanalization below the clinoid segment and at the clinoid segment and beyond. The follow-up visit was conducted at least 3 months after surgery, and stenosis or occlusion recurrence was confirmed by review of CTA or DSA scan. Results: The databases were searched and 1,709 records were identified, of which 16 articles were used in the meta-analysis, and 464 CICAO patients with complete data who underwent hybrid surgery were enrolled. Hybrid surgery was associated with higher success rates (RD = 0.87, 95% CI [0.84–0.91], p < 0.00001) than EI (OR = 4.71, 95% CI [2.32–9.56], p < 0.0001). The procedural success rate in the below-clinoid segment group was significantly higher than that in the clinoid segment and beyond group (OR = 13.76, 95% CI [5.31–35.66], p < 0.00001). The total periprocedural complication rate was low (RD = 0.11, 95% CI [0.07–0.15], p < 0.00001 and RD = 0.04, 95% CI [0.00–0.07], p = 0.03). Target vessel restenosis or reocclusion occurred in 35 patients (8%) during the follow-up period (RD = 0.08, 95% CI [0.04–0.12], p < 0.0001). Conclusion: Hybrid surgery is the combination of the advantages of open surgery and EI, has a high success rate and a low risk of recurrence of stenosis and occlusion in the long term. Randomized controlled trials on hybrid surgery for internal carotid artery occlusion are necessary.
Development of an instrument to evaluate the knowledge that the patient with hepatic cirhosis has about his disease and treatment
Authors: Medeiros Kayo Augusto de Almeida , Carvalho Bárbara Justo , Nii Fernanda , D’Albuquerque Luiz Augusto Carneiro , Meyer Alberto , Andraus Wellington
Published: December 2023

Introduction: hepatic cirrhosis (HC) is a disease with high morbidity and mortality in Brazil. Its treatment is complex and requires from lifestyle changes to large surgeries such as liver transplantation. To reach the best treatment results, it is necessary to guarantee a good patient’s adherence to the treatment. Studies indicate that the patient’s self-knowledge about his or her clinical condition is a determining factor in its adherence.Objectives: to assist in the design of an instrument that evaluates knowledge about the disease and treatment of HC. To improve the student knowledge on liver cirrhosis. Development of skills related to physical examination of the patient with HC.Methodology: The development process of the instrument will be divided into 3 stages: construction of the instrument (1st stage), evaluation of content validity and clarity of the instrument (2nd stage) and assessment of the reliability of the instrument (3 rd stage).Results: an instrument to evaluate the cirrhotic patient knowledge about the disease was made, analyzed by specialists and approved in the criteria proposed.Conclusions:1) The development of the instrument followed the steps described in literature.2) The suggestion of the evaluators allowed to restructure the questions making them clearer and more relevant to the proposal of the instrument.3) it was possible to achieve satisfactorily the proposal of the construction of the instrument.Key words: Liver cirrhosis; Self concept; Surveys and questionnaires; Health education.
Non-invasive brain stimulation for negative symptoms in schizophrenia: an updated systematic review and meta-analysis
Authors: Osoegawa Caio , Trevizol Alisson Paulino
Published: December 2023

Background: Schizophrenia is a mental disorder with significant social and economic burden. Although current pharmacological treatments are effective for controlling the positive symptoms, medications have small-to-no effect for the treatment of negative symptoms. Noninvasive Brain Stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and trigeminal nerve stimulation (TNS) are emerging as neuroplasticity enhancer, boosting treatment response for refractory symptoms in Schizophrenia. Objective: To assess the efficacy of non-invasive brain stimulation for negative symptoms in schizophrenia in randomized clinical trials (RCTs). Methods: A systematic review in the Medline and Cochrane Library databases was performed up to May 31, 2017. The primary outcome was the Hedges’ g for continuous scores in a random effects model. Heterogeneity was evaluated with the I 2 and the χ2 test. Publication bias was assessed using the Begg’s funnel plot. Meta-regression was performed usingthe random-effects model modified by Knapp and Hartung. Results: We included 31 RCTs (n=1272); most with small-to-modest sample sizes. Active stimulation was significantly superior over sham for negative symptoms (Hedges’ g = 0.23; 95% CI 0.11 – 0.34). The funnel plot and the Eggers test showed that heterogeneity and the risk of publication bias were low (I2 =2.3%, p=0.429 for the χ2 test; p=0.179 for the Egger’s test). Meta-regression showed no influence of any variable on the results found. Both transcranial magnetic stimulation and transcranial direct current stimulation were superior to sham. In a subgroup analysis, no trial was alone responsible for the positive results observed. Conclusion: NIBS active was superior to sham stimulation for the amelioration of negative symptoms in schizophrenia. We found no considerable heterogeneity or publication bias in our analysis, corroborating to the strength of our findings. Further RCTs with larger sample sizes are needed to clarify the precise impact of NIBS in negative symptoms in schizophrenia.
Treatment of diabetic feet with ozone therapy in primary health care
Authors: Santos Larissa Rodrigues , Bastos Ariane Lopes , Xavier Patricia Vieira , Silva Rafaela Roque da , Oliveira Taynara Carvalho de , Souza Juliana Cedro de , Abreu Juliana de Moraes Baldan
Published: December 2023

Introduction: The ozone therapy is a therapeutic practice by ozone administration for the purpose of mainly assisting in disinfection and healing of extensive wounds through increased tissue oxygenation. It is possible to observe ulceration in the feet because of diabetes mellitus, a chronic disease affecting more than 120 million people worldwide. Therefore, the application of ozone therapy as an integrative practice in primary health care is valid, since that practice is presented as a supporting in the treatment of these injures, as well as its low cost. Objectives: The study aims the treatment of diabetic foot injuries through the ozone therapy, as well as its cost-benefit, focusing on the primary health care application at Brazil’s Unified Health System (SUS), in order to provide a less invasive, humanized and easily accessible treatment to diabetics patients, increasing their life quality.Methodology: A bibliographical research was conducted with general concepts about ozone therapy and diabetes, by databases of free access available online, through the following keywords: ozone therapy, diabetes, ulcer, healing, integrative medicine, primary health care, diabetic foot, complementary therapies. Relevant scientific articles developed between 2010 and 2020 were selected. Results: Diabetic patients present a greater chance of developing ulcer because of ceaselessly oxidative stress over cells. Ozone therapy provides promising prognosis being ozone activate the cellular metabolism inducing antioxidant enzymes synthesis which suppress the oxidative stress by increasing the oxygen supply to affected tissues, that provides its bactericidal and fungicidal behavior. Besides, it stimulates neovascularization and tissue proliferation, consequently, occurs an inflammation and pain decrease. Finally, ozone therapy promotes cost in 20% to 80% decline comparing to procedures generally administered. Discussion and Conclusion of the Results: Ozone therapy speed up wound healing in patients with diabetic ulcers and admit a better life quality for them as well as avoiding amputations, which enable its inclusions as a medical procedure in this case. Those benefits justify why ozone therapy is recommended by health policies planning to SUS, because it is a technique easily applied at primary health care. In addition, it is supported by the National Policy on Integrative and Complementary Practices which facilitate its implementation at care and prevention actions developed by the Family Health Strategy, since it is the mean of treatment for diabetic patients in a longitudinal and continual form. Primary Health Care requires practicality, efficacy and good cost-benefit, and ozone therapy is a viable alternative for the treatment of diabetic foot.
Relação entre risco e medo de queda em idosas participantes de um projeto social
Authors: Silva Izabela Cipriano da , Oliveira Daniel Vicentini de , Nascimento Júnior José Roberto Andrade do , Fidelix Yara Lucy , Nogueira Greicequerli , Bennemann Rose Mari , Acencio Fabio Ricardo
Published: December 2023

Objetivo: Verificar a relação entre o risco e o medo da queda em idosas participantes de um projeto social. Métodos: Estudo transversal, realizado com 59 idosas participantes de um projeto social ofertado no município de Cianorte–PR. Para avaliar o medo de cair foi utilizada a FES-1-BRASIL. Para avaliação da mobilidade da marcha e risco de queda foi aplicado o teste Timed Up & Go (TUG). Para análise dos dados foi utilizado a estatística descritiva (frequência, percentual, média e desvio padrão), o teste de Kolmogorov-Smirnov, teste t de Student independente e a correlação de Pearson, sendo adotada a significância de p< 0,05. Resultados: Idosas apresentaram risco moderado a alto de cair. Ao analisar o medo de cair das idosas, observou-se o escore médio de 27,4 ± 6,91. Já ao avaliar a mobilidade e equilíbrio de idosos através do TUG, verificou-se que o tempo médio foi de 11,6 ± 2,9 segundos. As idosas mais jovens e que estavam há mais de três anos no projeto apresentaram menor medo de cair e menor risco de queda (p= 0,039 e p= 0,001, respectivamente). Foram encontras as seguintes correlações significativas (p< 0,05):  medo de cair com tempo de participação no projeto (r= -0,42); risco de queda com a idade (r= 0,29) e medo de cair (r= 0,56). Conclusão: A partir dos resultados obtidos, conclui-se que a idade e o tempo de participação no projeto parecem ser fatores intervenientes no medo de cair e no risco de quedas das idosas. Ressalta-se que as idosas mais jovens e com maior tempo de participação no projeto apresentaram menor medo e risco de cair. Além disso, foi possível observar que quanto maior o risco de queda, maior o medo de cair.
Atuação do fisioterapeuta no serviço de emergência de um hospital de pronto socorro referência em trauma
Authors: Rosa Rita de Cássia Sebastião da , Thomaz Rafaela Prusch , Vitti Mariana Karla , Rosa Luis Henrique Telles da , Cardoso Éder Kröeff
Published: December 2023

Emergências hospitalares são portas de entrada para pacientes graves com potencial risco de morte. Em um hospital referência em trauma, a função do fisioterapeuta dentro da equipe multiprofissional ainda tem necessidade de ser bem estabelecida. Objetivo: Discorrer sobre a atuação do fisioterapeuta no serviço de emergência de um hospital de pronto socorro referência em trauma e apresentar o perfil do paciente atendido. Método: Trata-se de uma pesquisa observacional descritiva, de caráter transversal retrospectiva a partir da análise dos atendimentos fisioterapêuticos registrados em prontuários de pacientes hospitalizados. Resultados: As causas mais frequentes de internação dos pacientes atendidos pela equipe de fisioterapia foram quedas (51,7%), acidentes de trânsito (14,9%), cardiovasculares (9,2%), agressões (9,1%), outros (8,3%) e respiratórias (6,8%). Quedas da própria altura com fratura de fêmur associadas representaram 26,4% da amostra. Nestes pacientes as condutas mais utilizadas pelos fisioterapeutas foram orientações, exercícios respiratórios, exercícios no leito e ajustes de posicionamento. O fisioterapeuta teve atuação com pacientes com pneumotórax, hemotórax ou hemopneumotórax submetidos à drenagem torácica, por meio de exercícios respiratórios expansivos, saída do leito e deambulação precoce. Observou-se também atuação com os pacientes em ventilação mecânica invasiva e não invasiva na sala vermelha. Conclusão: O fisioterapeuta, fazendo parte da equipe multiprofissional, apresenta importante atuação nas salas de emergência de um hospital de trauma, tal como o atendimento a pacientes submetidos a ventilação mecânica invasiva e não invasiva, uso de técnicas de fisioterapia respiratória para expansão pulmonar e remoção de secreções bem como a utilização de técnicas de cinesioterapia para manutenção e ganho de força muscular e funcionalidade.
Influência do tratamento fisioterapêutico na independência funcional de pessoas com hemofilia submetidas à sinovectomia radioativa
Authors: Silva Cecília do Socorro Sousa da , Glória Luzielma Macêdo , Melo Roberta Bentes de
Published: December 2023

A sinovectomia radioativa (SR) é considerada o tratamento de eleição no controle da sinovite crônica não responsiva ao tratamento conservador, sendo recomendado tratamento fisioterapêutico para a melhora da funcionalidade. Objetivo: Verificar a influência do tratamento fisioterapêutico na independência funcional e saúde articular de hemofílicos após tratamento com SR. Método: Trata-se de um estudo descritivo, retrospectivo, analítico e metodologia quali-quantitativa. Realizou-se avaliação fisioterapêutica, aplicação do HJHS para avaliação da saúde articular e Escore FISH para avaliação da independência funcional. Os participantes foram subdivididos em dois grupos de acordo com a realização ou não da fisioterapia após a SR. Resultados: Participaram do estudo 8 pessoas com hemofilia A, sexo masculino, média de idade de 19±5,3 anos. Foram 12 articulações submetidas a SR, dessas 41,67% cotovelos, 33,33% joelhos e 25% tornozelos.  Na comparação dos grupos, não houve diferença estatística entre os eles nas variáveis: saúde articular e a Independência Funcional. Conclusão: O estudo é uma primeira tentativa de descrever o impacto da fisioterapia na independência funcional e saúde articular de hemofílicos submetidos à SR. Embora possua limitações, foi possível observar que o grupo que não realizou fisioterapia apresentava melhor saúde articular e melhor independência funcional previamente à SR em comparação ao grupo que realizou fisioterapia; porém, o grupo fisioterapia apresentava pior quadro global, com a funcionalidade impactada por outras articulações e não somente aquela tratada com SR, apresentando maior número de articulações alvo.
Autopercepção dos benefícios da mobilização miofascial em praticantes de exercício físico: um estudo transversal
Authors: Horbach Heiffer , Luz Heidy Horbach , Antunes Mateus Dias , Wittig Daniela Saldanha
Published: December 2023

A mobilização miofascial vem sendo utilizada com frequência no meio esportivo como forma de melhorar as restrições da fáscia que surgem com as atividades físicas.  Objetivo: Analisar e comparar os benefícios da mobilização miofascial para praticantes adultos de exercício físico regular, verificando os métodos e técnicas utilizados, assim comparando a maior eficácia segundo a percepção dos praticantes. Métodos: Trata-se de um estudo transversal onde foi aplicado um questionário online a 160 pessoas de ambos os sexos, com o intuito de analisar informações de técnicas aplicadas e sua eficácia. Os dados foram analisados por meio da estatística descritiva. Resultados: Os resultados demonstraram que a satisfação e benefícios foram predominantes, e o uso da técnica manual foi a de maior escolha entre os praticantes, ressaltando que a maioria foi aplicada por fisioterapeutas. Conclusões: Quem utiliza a técnica, independente da forma executada, os resultados são considerados satisfatórios e trazem bem-estar e benefícios à saúde dos praticantes de exercício físico.
Atividade física, ajuste à prótese e condição de saúde de pessoas com amputação de membro inferior
Authors: Lima David Braga de , Castro Thiago Luis da Silva , Weber Fernanda Matos , Reis Milena Ketzer Caliendo dos , Silva Rudney da
Published: December 2023

Objetivo: Relacionar atividade física, características demográficas e clínicas, ajuste à prótese e condições de saúde relacionada à qualidade de vida de adultos com amputações de membro inferior. Método: Participaram do estudo 70 indivíduos com amputações de membro inferior de ambos os sexos. Os dados foram coletados por meio de ficha para caracterização dos participantes, do Physical Activity Scale for Individual with Physical Disabilities (PASIPD), da Trinity Amputation and Prosthesis Experience Scales–Revised (TAPES-R) e do Short Form Health Survey (SF-12). Os dados foram analisados por meio de estatística descritiva e inferencial visando correlações, comparações e associações. Foi adotado p menor ou igual a 0,05. Resultados: Os resultados demonstraram que os participantes tiveram gasto energético de 26,93 MET h/d e maiores médias de condições de Saúde Relacionado à Qualidade de Vida no domínio saúde mental, ainda apresentaram maiores médias relacionados ao Ajuste à Prótese no domínio Social (3,56) com Grau de Ajuste acima da média (6,42). Conclusão: Os participantes do estudo apresentaram bom nível de atividade física, bom ajuste à prótese, boa saúde física e mental, melhor adaptação à amputação e participação. Além disso, também foi observado uma pior relação na adaptação entre pessoas com amputação acima do joelho, quando comparadas às amputações abaixo do joelho.
Efeito imediato da mobilização com movimento (MWM) em pacientes com dor lombar: um estudo randomizado controlado
Authors: Fraga Joyce Maria , Camargo Tayla Maria Fraga , Mendonça Thayane Gomes de , Soares Simone Ribeiro da Costa , Silva Júlia Helena , Carlos Bruna Leonel , Alves Ricardo da Silva
Published: December 2023

Objetivo: Analisar o efeito  da Mobilization Whith Movement (MWM) do conceito Mulligan na percepção de dor nociceptiva e neuropática, na amplitude e na mobilidade articular de indivíduos com dor lombar. Métodos: Trata-se de um ensaio clínico randomizado e controlado, de 30  voluntários com dor lombar inespecífica, divididos em: Grupo Intervenção (GINT) que recebeu a mobilização articular com deslizamentos apofisários naturais mantidos (MWM - SNAGs); Grupo Controle (GCONT), que recebeu uma mobilização articular placebo. Os voluntários foram avaliados pela escala numérica de dor (EVN); pelo teste modificado de Schober (TMS) para a mobilidade da coluna lombar e pelo DN4 para avaliação da dor neuropática e nociceptiva. Resultados: GINT apresentou  aumento da flexão lombar (pré intervenção= 81,21±15,23°; pós-intervenção= 90,00±19,62°, p= <0,05), da mobilidade da coluna lombar no TMS (pré= 15,33±1,05 pós= 16,08±1,02, p= <0,05) e redução da percepção de dor pela EVN (pré= 5,33±2,26; pós= 1,47±2,61= p< 0,05) e no GCONT (pré= 4,07±2,34; pós= 2,20±1,93, p < 0,05). Conclusão: A intervenção com MWM - SNAGs promoveu melhora da ADM e da mobilidade na flexão da coluna lombar, associada com redução da dor nociceptiva no GINT e no GCONT.
Transcriptome profiling of Bergenia purpurascens under cold stress
Authors: Zhang Xuebin , Yu Fang , Lyu Xin , Chen Jingyu , Zeng Hongyan , Xu Nuomei , Wu Yufeng , Zhu Qiankun
Published: December 2023

Bergenia purpurascens is an important medicinal, edible and ornamental plant. It generally grows in high-altitude areas with complex climates. There have been no reports about how B. purpurascens survives under cold stress. Here, the B. purpurascens under low temperature were subjected to transcriptomics analysis to explore the candidate genes and pathways that involved in the cold tolerance of B. purpurascens. Compared with the control treatment, we found 9,600 up-regulated differentially expressed genes (DEGs) and 7,055 down-regulated DEGs. A significant number of DEGs were involved in the Ca2+ signaling pathway, mitogen-activated protein kinase (MAPK) cascade, plant hormone signaling pathway, and lipid metabolism. A total of 400 transcription factors were found to respond to cold stress, most of which belonged to the MYB and AP2/ERF families. Five novel genes were found to be potential candidate genes involved in the cold tolerance of B. purpurascens. The study provide insights into further investigation of the molecular mechanism of how B. purpurascens survives under cold stress.
Molluscum contagiosum survey – common approach and attitude towards treatment and research in Dutch general practice
Authors: Watjer Roeland M. , Bonten Tobias N. , Quint Koen D. , Hasani Mohammad M. , Numans Mattijs E. , Eekhof Just A.H.
Published: December 2023

Background

Molluscum contagiosum (MC) can cause significant burden in children. So far, pharmacological treatment has not been proven beneficial. More rigorous interventions have not been well studied. Current guidelines advise a “wait and see” policy. However, children and their parents frequently visit their GP requesting intervention. Therefore, the aim of this study was to gain insight into the approach to MC by GPs and parents’ expectations and to investigate willingness to participate in an interventional study.

Methods

A survey study was carried out among GPs and parents using a questionnaire for each group inquiring about MC and potential study participation. Descriptive statistics were used to analyze results and logistical regression to investigate factors influencing participation.

Results

The majority of GPs (88%) preferred an expectative approach; only 21% were willing to participate in a trial as proposed. GPs estimating ≥ 50% of parents would request treatment, were more likely to participate. Most responding parents did or would visit their GP requesting treatment. In contrast to GPs, 58% were willing to participate. Parents preferring cryotherapy or curettage were more likely to participate.

Conclusion

Our study demonstrated that the majority of GPs preferred a conservative approach, adhering to current guidelines. However, most parents preferred treatment to resolve MC and symptoms. Parents’ willingness to participate was much higher than GP’s, reflecting parents’ desire for treatment. These findings underscore the need for continued therapeutic research. Careful preparation and selection of GPs and patients will be essential to ensure the feasibility of such an endeavor.

Trial registration

This survey study was not part of a clinical trial.
High risk fertility behaviour and health facility delivery in West Africa
Authors: Budu Eugene , Ahinkorah Bright Opoku , Okyere Joshua , Seidu Abdul-Aziz , Aboagye Richard Gyan , Yaya Sanni
Published: December 2023

Background

Evidence suggests that women who give birth in a health facility have lower odds of experiencing pregnancy complications and significantly reduced risk of death from pregnancy-related causes compared to women who deliver at home. Establishing the association between high-risk fertility behaviour (HRFB) and health facility delivery is imperative to inform intervention to help reduce maternal mortality. This study examined the association between HRFB and health facility delivery in West Africa.

Methods

Data for the study were extracted from the most recent Demographic and Health Surveys of twelve countries in West Africa conducted from 2010 to 2020. A total of 69,479 women of reproductive age (15–49 years) were included in the study. Place of delivery was the outcome variable in this study. Three parameters were used as indicators of HRFB based on previous studies. These were age at first birth, short birth interval, and high parity. Multivariable binary logistic regression analysis was performed to examine the association between HRFB and place of delivery and the results were presented using crude odds ratio (cOR) and adjusted odds ratio (aOR), with their respective 95% confidence interval (CI).

Results

More than half (67.64%) of the women delivered in a health facility. Women who had their first birth after 34 years (aOR = 0.52; 95% CI = 0.46–0.59), those with short birth interval (aOR = 0.91; 95% CI = 0.87–0.96), and those with high parity (aOR = 0.58; 95% CI = 0.55–0.60) were less likely to deliver in a health compared to those whose age at first delivery was 18-34 years, those without short birth interval, and those with no history of high parity, respectively. The odds of health facility delivery was higher among women whose first birth occurred at an age less than 18 years compared to those whose age at first birth was 18-34 years (aOR = 1.17; 95% CI = 1.07–1.28).

Conclusion

HRFB significantly predicts women's likelihood of delivering in a health facility in West Africa. Older age at first birth, shorter birth interval, and high parity lowered women’s likelihood of delivering in a health facility. To promote health facility delivery among women in West Africa, it is imperative for policies and interventions on health facility delivery to target at risk sub-populations (i.e., multiparous women, those with shorter birth intervals and women whose first birth occurs at older maternal age). Contraceptive use and awareness creation on the importance of birth spacing should be encouraged among women of reproductive age in West Africa.
Full-round impossible differential attack on shadow block cipher
Authors: Liu Yuting , Li Yongqiang , Chen Huiqin , Wang Mingsheng
Published: December 2023

Lightweight block ciphers are the essential encryption algorithm for devices with limited resources. Its goal is to ensure the security of data transmission through resource-constrained devices. Impossible differential cryptanalysis is one of the most effective cryptanalysis on block ciphers, and assessing the ability of resisting this attack is a basic design criterion. Shadow is a lightweight block cipher proposed by Guo et al. (IEEE Internet Things J 8(16):13014–13023, 2021). It utilizes a combination of ARX operations and generalized Feistel structure to overcome the weakness of the traditional Feistel structure that only diffuses half in one round. In this paper, we focus on the differential property of Shadow and its security against impossible differential cryptanalysis. First, we use the SAT method to automatically search for a full-round impossible differential distinguisher of Shadow-32. Then, based on the experimental results, we prove that Shadow has a differential property with probability 1 based on the propagation of the state. Further, we can obtain an impossible differential distinguisher for an arbitrary number of rounds of Shadow. Finally, we perform a full key recovery attack on the full-round Shadow-32 and Shadow-64. Both experimentally and theoretically, our results indicate that Shadow is critically flawed, and regardless of the security strength of the internal components and the number of rounds applied, the overall cipher remains vulnerable to impossible differential cryptanalysis.