bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential expression of TMIGD1 in colorectal cancer.
Authors: Mamoor Shahan
Published: March 2023

Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with colorectal cancer (CRC). We found significant differential expression of the gene encoding transmembrane and immunoglobulin domain-containing 1, TMIGD1, when comparing colorectal tumors to the tissue of origin, the colon. TMIGD1 mRNA was present at significantly lower quantities in tumors of the colon as compared to normal colorectal tissue. TMIGD1 expression changes may be important for the initiation or progression of human CRC.
Investigation of Consumer Attitude Impacting Parameters in Online Shopping
Authors: Zam Milad , Rezasoltani Amin , Ramezanian Hasan , Tavakoli Mohammadhosein
Published: March 2023

The bulk of customer purchases are impacted by their assessment of the product's benefits and drawbacks as well as its emotional aspects. Research in psychology and marketing has confirmed that customer emotions are involved at various points in the buying process. The current study aims to identify the aspects and factors that may influence customers' emotions when they buy high-end cosmetics. In order to identify the different facets of customer emotions, a qualitative study using in-depth semi-structured interviews with 23 customers of high-end cosmetics and health products in Telegram groups was first conducted. This investigation resulted in the discovery of numerous client emotional dimensions as well as a list of variables that may serve as emotional antecedents in the target audience. The next step is determining the factors influencing customer sentiments based on group consensus. 15 professionals and experts in marketing, psychology, corporations importing luxury cosmetics and hygiene products who are active on online networks, and managers of luxury cosmetics and hygiene groups in online spaces made up the panel at this point. In three steps, the consensus of experts was obtained, and 36 elements influencing customers' emotions were identified and graded based on the applicability or strength of the perceived effect in the experts' eyes. These were then divided into three groups: situational variables, group and product variables, and individual variables.
Differential expression of EPHX4 in colorectal cancer.
Authors: Mamoor Shahan
Published: March 2023

Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined published and public microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with colorectal cancer (CRC). We found significant differential expression of the gene encoding epoxide hydrolase 4, EPHX4, when comparing colorectal tumors to the tissue of origin, the colon. EPHX4 mRNA was present at significantly higher quantities in tumors of the colon as compared to normal colorectal tissue. Analysis of human survival data revealed that expression of EPHX4 in rectal tumors was correlated with overall survival in patients with rectal cancer. EPHX4 expression changes may be important for the initiation or progression of human CRC.
Differential expression of SLC51B in colorectal cancer.
Authors: Mamoor Shahan
Published: March 2023

Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined published and public microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with colorectal cancer (CRC). We found significant differential expression of the gene encoding solute carrier family 51 beta subunit, SLC51B, when comparing colorectal tumors to the tissue of origin, the colon. SLC51B mRNA was present at significantly lower quantities in tumors of the colon as compared to normal colorectal tissue. SLC51B expression changes may be important for the initiation or progression of human CRC.
Why statistical adjustment for social and economic background fails and what to do about it
Authors: Debrouwere Stijn , Rosseel Yves
Published: March 2023

Scholars often hope to filter class, clout, poverty, deprivation, inequity and lack of opportunity from their analyses: factors that affect both how we act and what we achieve, and thereby muddle other associations in the data. In practice, adjustment relies on self- reported low-fidelity proxies such as occupation and education that capture but a fraction of the variance due to social and economic background and inflate the estimated effects of any correlated variable. When background is measured in a way that matches the research at hand, included in the analysis multidimensionally and not as a composite, and corrected for measurement error, it is not rare to see regression coefficients cut in half. We illustrate how poor measurement and poor models lead to residual confounding by social and economic background, review reliable alternatives to generic measures of socioeconomic status and demonstrate the effectiveness of statistical corrections for any error that remains.
Advanced testing of the LoT-hypothesis by social reasoning
Authors: Grüning David Joachim
Published: March 2023

I elaborate on Quilty-Dunn et al.’s (2022) integration of the Language-of-Though hypothesis in social reasoning by outlining two discrepancies between the experimental paradigms referred to by the authors and the social world: self-referential projection and deliberate thinking in experiments. Robust tests of the hypothesis in social reasoning should include observational, natural, and cross-cultural approaches.
Burnishing the blueprint of speech assessment with natural language processing: methods to characterize subtle impairments on individuals in at-risk mental states from a large urban population.
Authors: Argolo Felipe Coelho , de Paula Ramos William Henrique , mota natalia , Gondim João Medrado , Lopes-Rocha Ana Caroline , Cecchi Guillermo , Corcoran Cheryl , Ara Anderson , Loch Alexandre
Published: March 2023

Spoken language is a key source of information for thought disorder evaluation. In the last decades, researchers linked psychopathology phenomena to their counterparts in natural language processing (NLP) analysis. Nonetheless, seemingly opposite traits remain unconciliated. For instance, psychotic speech comprises incoherent trails, but also highly associated ones. In order to address some of the remaining gaps, we leveraged procedures from dynamical systems and graph theory. We examined transcribed interviews of 133 individuals — 60 in at-risk mental states (ARMS) and 73 healthy controls — screened from 4,500 quota-sampled citizens in a large metropolis. SIPS was used to assess psychotic symptoms. NLP features were correlated with psychotic traits (Spearman’s ρ) and ARMS status (Wilcoxon signed-rank tests, general linear models and ensemble machine learning algorithms). The general trait (ω), negative, disorganized and general symptoms were correlated with snippets made of consecutive similar words. Namely, their frequency, average/maximum size, heterogeneity and the average number of unrelated words between such snippets. Positive symptoms were associated with adjective use. Average graph centrality was inversely correlated with the general trait. NLP features presented good performance as input in machine learning classification using the AdaBoost model with Random Forests as base learner (F1 score: 0.83, AUC: 0.93, Balanced Accuracy: 0.86).The existence of loosely connected words (e.g. incoherence, looseness, derailment) is well studied. Conversely, NLP models of perseveration (e.g. higher likelihood of chaining together islands of closely related words) and circumstantiality are brought forth in this work. Evidence shows good performance of NLP for clinical decision support in ARMS screening and assessment of subclinical psychosis. We show that a blueprint for speech-based psychometric evaluation is only a few pieces away. We highlight these fields for future research: clanging (a low hanging fruit), environmental context, task-related differences and interpersonal interactions.
NLP and Graph embeddings: TextGraphs.jl
Authors: Argolo Felipe Coelho , Gondim João Medrado , Lopes-Rocha Ana Caroline , Ara Anderson , Loch Alexandre , mota natalia
Published: March 2023

Natural language processing (NLP) techniques analyze formal properties of speechin humans. One way of analyzing language is through graph embeddings. Graphs are cunningly simple abstractions, which have vertices and nodes as basic elements. Nevertheless, graphs were revealed to be very useful abstractions to describe associations in real-world phenomena whenever there are coupled elements. Graph embeddings associate words with nodes and adjacency in a phrase with links (edges). When words are repeated, the respective node is linked twice. Some attributes of these “speech graphs” are correlated with mental states, such as connectivity (e.g. largest connected components).The first section of this article reviews theoretical basis for the analysis of text-based graph embedding (”Text Graphs” or ”Speech Graphs”). We present standard procedures of text embedding and discuss graph properties (e.g. connected components) in this context.Some features brought by TextGraphs.jl (e.g. density, centrality) were not used before in literature. The second section covers applications, including installation, basic features, and vignettes with example cases
Examining cross-sectional and longitudinal relationships between multidomain physical fitness metrics, education, and cognition in Black older adults
Authors: Stauder Matthew , Hiersche Kelly J. , Hayes Scott M.
Published: March 2023

A limited number of studies examine cognitive aging in Black or African American older adults. The purpose of this study was to explore the relationships between health-related fitness metrics, education, and cognition at baseline and over a 4-year follow-up in a sample of Black older adults. Data were analyzed from 321 Black older adults in the Health and Retirement Study (HRS). Physical fitness was assessed with measures of gait speed, peak expiratory flow, grip strength, and body mass index. Global cognition was assessed with an adapted version of the Telephone Interview for Cognitive Status (TICS). Analyses of relative importance and hierarchical multiple regression were used to examine baseline cross-sectional relationships. Multiple logistic regression was used to examine prospective relationships with longitudinal cognitive status. Education was the strongest predictor of global cognition at baseline and follow-up. More years of education significantly increased the odds of maintaining cognitive status at 4-year follow-up. After accounting for education, gait speed was independently associated with baseline cognitive performance and accounted for additional variance. Grip strength, peak expiratory flow, and body mass index were not significantly associated with cognition. The results indicated that modifiable variables, including years of educational attainment and gait speed, are more strongly associated with global cognition than other modifiable variables including body mass index, grip strength, and peak expiratory flow. The lack of observed associations between other fitness variables and cognition may be attributable to the brief assessment methods implemented, which was necessitated by the large-scale, epidemiological approach of the HRS study.
Evaluation of chemical compounds in Plectranthus barbatus leaves extract for application in reduction of tannery wastewater toxicity
Authors: Obiero DK , Ombui JN , Mbaria JM , Yenesew A , Onyuka AS , Kilee TN
Published: March 2023

Plectranthus barbatus Andr. grows in Kenya, sub-Saharan Africa, Australia, Brazil and Asia and is one of the most important species of the Lamiaceae family. The plant is widely mentioned in traditional medicine in Africa and Asia. Some of the compounds previously isolated from the plant include diterpenoids, phenolic acids and essential oils. The objective of the study was to evaluate and determine the presence of chemical compounds in Plectranthus barbatus Andr. leaves extract of tannin nature that can be beneficial ingredients in processing clean leather and at the same time reduce environmental pollution. The Plant’s leaves were collected from Nyamira County then dried and ground to desired mesh before extraction was done with water and 80 % methanol in water. The methanolic solid extract that was recovered after freeze drying was subjected to column chromatography. The pure fractions were analyzed using Nuclear Magnetic Resonance spectroscopy and compared to those previously analyzed using High Pressure Liquid Chromatography. Some of the compounds isolated include phenolics e.g. Para-Hydroxybenzoic acid and Diterpenes. Water solid extract was used in pre-tanning and re-tanning applications followed by analysis of Biological Oxygen Demand, Chemical Oxygen Demand, pH and total chrome content of respective wastewaters. Tannery liquor from re-tanning and pre-tanning combinations with Plecranthus barbatus leaves extract showed reduced toxicity to the environment with pH of 7.97 and 2.96 respectively as compared to chrome tannage liquor that recorded a relatively more acidic pH of 2.30. Biological Oxygen Demand, Chemical Oxygen Demand and chrome content levels were 230.00 mg/l, 4520.00 mg/l and 9.69 ppm respectively for effluent from Plectranthus barbatus retannage against 320.10 mg/l, 2331.20 and 5.03 ppm respectively from pretannage of the same extract. Permissible limits for pH, Biological Oxygen Demand, Chemical Oxygen Demand and total chrome in discharged tannery wastewater are 5.5 – 10.0, 125 mg/l – 1000 mg/l, 300 mg/l – 3000 mg/l, and 1.0 ppm – 10.0 ppm respectively. Pretanning with Plectranthus barbatus leaves extract during leather processing was more effective is reduction of tannery wastewater toxicity although, the use of pretanning and retanning in a single tannage might yield more promising results.
Brief Reviews of Books and Products: Open Update Podcast, Season Two
Authors: Larose Cassandra
Published: March 2023

A brief review of Season Two of the Open Update Podcast.
The Impact of Solid-State Physics on Modern Science: A Critical Review
Authors: Ramana P. Venkata
Published: March 2023

Solid-state physics has played a crucial role in the development of modern science. This critical review explores the impact that solid-state physics has had on various fields, including materials science, condensed matter physics, and electronics. Solid-state physics has enabled the creation of new materials with novel properties, such as high-temperature superconductors and semiconductors. It has also revolutionized the field of electronics, leading to the development of microprocessors and computer technology. This review examines the historical context of solid-state physics and its significant contributions to the modern scientific landscape. Furthermore, this critical review evaluates the limitations and challenges that the field currently faces and discusses future directions for research. Ultimately, this review highlights the importance of solid-state physics in modern science and its potential for further breakthroughs in various scientific fields. The abstract introduces the topic of the impact of solid-state physics on modern science and briefly mentions the various fields that solid-state physics has contributed to. It also notes some of the key advances that solid-state physics has enabled, including the development of new materials with unique properties and the creation of electronic devices such as microprocessors. The abstract then goes on to provide more detail, exploring the historical context of solid-state physics and its significant contributions to the scientific landscape. This could include a discussion of some of the key discoveries and innovations that have arisen from solid-state physics research, as well as some of the prominent scientists who have worked in the field. The abstract also touches on some of the limitations and challenges that the field currently faces, such as the difficulty of working with complex materials and the need for new theoretical frameworks to better understand solid-state systems. Finally, it highlights the potential for further breakthroughs in various scientific fields, underscoring the ongoing importance of solid-state physics research. Overall, the abstract provides a comprehensive overview of the topic, laying out the key themes and arguments that the review will explore in more detail.
The Effect of Coating Materials Towards the Quality of Crude Albumin Powder Made from Snakehead Channa striata
Authors: Suprayitno Eddy , Sulistiyati Titik Dwi , Tambunan Jeny Ernawati , Puspitasari Yunita Eka
Published: March 2023

Background and aim: Snakehead (Channa striata) contains protein 25.5% including albumin. C. striata contains approximately crude albumin 6.22% and the crude albumin extract has been used as wound healing supplement widely in Indonesia. Recently, the albumin extract has been produced in powder form. Albumin is classified as a globular protein, and the properties have been influenced by temperature and pH value. Therefore, coating material is needed to protect albumin, to stabilize the properties from protein denaturation and to improve the end-product quality. The aim of this study was to determine the effect of adding coating materials such as carboxymethyl cellulose (CMC), chitosan, alginate and pectin towards quality of crude albumin powder made from C. striata. Methods: The method used in this study was experimental method. CMC, chitosan, pectin and alginate have been added to crude albumin extract with five differences concentrations, respectively. The concentration of coating material were CMC 3%, chitosan 2%, alginate 2%, and pectin 1%. The parameters of this experiment were albumin content, protein content, moisture content, lipid content, ash content, water absorption and yield. Results: The results showed that albumin content was 8.09% (CMC), 7.29% (chitosan), 7.37% (alginate) and 6.73% (pectin). CMC 3% showed the highest albumin content among others coating materials. The nutritional value of albumin powder with additional CMC 3% was albumin content 8.08%, protein content 32.55%, moisture content 5.47%, ash content 3.30%, lipid content 4.91%, water absorption 2.37% and yield 5.99%. The lightness of the best treatment (CMC 3%) was 26.30 ±0.57. The amino acid analysis from the albumin powder coated by CMC 3% showed that this product contained amino acid are glutamic acid, aspartic acid, leucine. Moreover, the fatty acid profiles showed that the crude albumin powder contained oleic acid and dokosadienoic acid. In conclusion, additional CMC 3% towards crude albumin powder improved the quality of final product. Conclusions: Optimal snakehead fish albumin powder was obtained at a concentration of 3% CMC coating addition with qualities including albumin content of 8.08%, water content 5.47%, ash content 3.3%, protein content 32.55%, fat content 4.91 %, 2.37% water vapor absorption and 5.99% yield. In the brightness parameter, the value of L * 23.35 is obtained. The highest amino acid profiles are glutamic amino acids and aspartic amino acids. The highest fatty acid profiles are linoleic and lauric fatty acids.
Fracture Mechanics Testing of Plastics
Authors: Osuna David Arencón , de Sousa Pais Antunes Marcelo , de Redondo Realinho Vera Cristina , Velasco José Ignacio
Published: March 2023

There are many different types of polymeric materials, ranging from glassy to semicrystalline polymers and even blends. Their mechanical properties range from pure elastic with very high strains to fracture (elastomers) to almost pure linear elastic (Hookian behavior) with low strains to fracture (glassy polymers). This article provides an overview of historical development of fracture behavior in polymers. It discusses the processes involved in three fracture test methods for polymers, namely linear elastic fracture mechanics, elastic-plastic fracture mechanics, and post-yield fracture mechanics.
Impact Loading and Testing
Authors: Major Zoltán , Stelzer Philipp S. , Kiehas Florian
Published: March 2023

This article reviews the impact response of plastic components and the various methods used to evaluate it.. It describes the effects of loading rate on polymer deformation and the influence of temperature and strain rate on failure mode. It discusses the advantages and limitations of standard impact tests, the use of puncture tests for assessing material behavior under extreme strain, and the application of fracture mechanics for analyzing impact failures. It also develops and demonstrates the theory involved in the design and analysis of thin-walled, injection-molded plastic components.
Thermal Analysis and Thermal Properties
Authors: Pieper Robert
Published: March 2023

This article discusses the thermal properties of engineering plastics and elastomers with respect to chemical composition, chain configuration, and base polymer conformation as determined by thermal analysis. It describes the processing of base polymers with or without additives and their response to chemical, physical, and mechanical stresses whether as an unfilled, shaped article or as a component of a composite structure. It summarizes the basic thermal properties of thermoplastics and thermosets, including thermal conductivity, temperature resistance, thermal expansion, specific heat, and glass transition temperature. It also provides information on polyimide and bismaleimide resin systems. Representative examples of different types of engineering thermoplastics are discussed primarily in terms of structure and thermal properties.
Organic Chemical-Related Failure of Plastics
Authors: Duvall Donald
Published: March 2023

The susceptibility of plastics to environmental failure, when exposed to organic chemicals, can limit their use in many applications. A combination of chemical and physical factors, along with stress, usually leads to a serious deterioration in properties, even if stress or the chemical environment alone may not appreciably weaken a material. This phenomenon is referred to as environmental stress cracking (ESC). The ESC failure mechanism for a particular plastics-chemical environment combination can be quite complex and, in many cases, is not yet fully understood. This article focuses on two environmental factors that contribute to failure of plastics, namely chemical and physical effects.
Characterization of Plastics in Failure Analysis
Authors: Jansen Jeffrey A.
Published: March 2023

This article reviews analytical techniques that are most often used in plastic component failure analysis. The description of the techniques is intended to familiarize the reader with the general principles and benefits of the methodologies, namely Fourier transform infrared spectroscopy, energy-dispersive x-ray spectroscopy, differential scanning calorimetry, thermogravimetric analysis, and dynamic mechanical analysis. The article describes the methods for molecular weight assessment and mechanical testing to evaluate plastics and polymers. The descriptions of the analytical techniques are supplemented by a series of case studies to illustrate the significance of each method. The case studies also include pertinent visual examination results and the corresponding images that aided in the characterization of the failures.
Adaptations versus original film premieres trends in broadband society: a comparative analysis
Authors: Fondevila-Gascón Joan-Francesc , Berbel-Giménez Gaspar , Blanco Cristian
Published: March 2023

In the era of the Broadband Society, cloud journalism, and streaming, the film industry is trying to modify traditional distribution channels. The adaptation of literary classics was one of the most widespread practices to obtain well-known, quality material for new productions. The objective of this research is to understand empirically what differences are involved in industry’s major production and distribution companies’ choice between adapting preexisting material or creating an entirely new film, as well as the benefits of adaptations. The methodology is comparative and quantitative, consisting of collecting data on films from the five major distributors (Universal, Warner Bros, Disney, Sony, and Paramount) from 2010 to 2019 and analyzing variables to detect market trends related to adaptations during that decade. We observed a higher percentage of adaptations as well as correlations between adaptations and film genre, distributor and genre, adaptations and awards, awards and genre, and genre and the film’s evaluation, as well as between distributor and average budget, adaptations and budget, adaptation and opening weekend box office takings, genre and profit, adaptations and worldwide box office revenues, ratings and worldwide box office takings, and awards and worldwide box office takings; however, this was not observed between adaptation and profit and the breakeven point. It is concluded that, despite the fact that the trend of using this practice has not increased in recent years, it provides a great advantage compared with debuting new intellectual property.
Dynamics of Soil Fertility Indicators of Chernivtsi Region
Authors: Hunchak Mykhailo , Solomiichuk Mykhailo , Pikovska Olena
Published: March 2023

For the development of measures for the rational use of soils, an agrochemical assessment of soils is important. The purpose of research was to establish the dynamics of changes in soil fertility indicators of the Chernivtsi region during 2011-2020. In our work were used laboratory and field methods, analysis and generalization. In the soil samples, the reaction of the soil environment, humus content, nitrogen content of easily hydrolyzable compounds, mobile phosphates and exchangeable potassium were determined. It was established that the acidity of the soil solution in the region is dominated by lands close to neutral (31.8%) and neutral (36.5%). The weighted average indicator of saline pH is 5.8, which corresponds to a close to neutral reaction of the soil solution. Compared to the previous survey round (2011-2015), the weighted average pH did not change. In terms of the level of humus provision, soils with an average humus content prevail (66.7%), and the weighted average humus content in the region is 2.7%. Compared to the previous survey round, the weighted average content of humus increased by 0.1%. According to the content of easily hydrolyzable nitrogen, most lands have very low (48.3%) and low nitrogen content (48.7%). The weighted average indicator of easily hydrolyzable nitrogen content for the reporting period is 106.4 mg/kg of soil, which corresponds to the low availability of this element. When compared with the previous survey round, the weighted average indicator of easily hydrolyzable nitrogen content increased by 0.9 mg/kg of soil. The region is dominated by lands with an average content of mobile phosphorus compounds (31.5%), and the weighted average indicator of the content of mobile phosphorus compounds is 56 mg/kg, which corresponds to average availability. Compared to the previous survey round, the weighted average indicator of phosphorus content increased by 4.0 mg/kg. In terms of the content of mobile compounds of potassium, lands with a very high content of potassium prevail (51.5%), although the weighted average indicator of the content of mobile compounds of potassium is 78 mg/kg, which corresponds to the average supply of the macroelement. Compared to the previous survey round, the weighted average indicator of phosphorus content increased by 15.4 mg/kg. The results of the article can be used in the process of training specialists in soil science and agronomy, and will also be useful for land users of the Chernivtsi region when planning measures for the rational use of soils.
Современные аспекты хирургической профилактики ишемического инсульта
Authors: Chernyak V. A. , Mishalov V. G. , Zorenko О. V. , Dybkalyuk S. V. , Zorgach V. Yu. , Borkivets A. N.
Published: March 2023

В статье рассмотрены основные положения, касающиеся вопросов хирургической и медикаментозной профилактики ишемического инсульта, основанные на результатах международных рандомизированных исследований и вошедшие в международные протоколы. Освещены также проблемные вопросы, связанные с нерешённой пока проблемой хирургической профилактики ишемического инсульта в вертебробазилярном бассейне. Приведённый материал обобщил опыт отечественных исследователей по вопросу хирургии позвоночных артерий. Результатом этих исследований стал вывод об учёте при хирургическом вмешательстве такого рода компонента экстравазальной позиционной компрессии позвоночных артерий преимущественно в сегменте С VІ. Началом таких исследований было открытие отечественными учёными анатомического образования: скалено-вертебрального канала в латеральном треугольнике шеи. В статье описаны также способы медикаментозной поддержки хирургических вмешательств с учётом приоритета отечественных производителей. Некоторые из указанных лекарственных средств уникальны.
Порівняльна характеристика показань до застосування фізичної реабілітації як складової пульмонологічної реабілітаціі при бронхолегеневих захворюваннях
Authors: Ivasyk N. O.
Published: March 2023

Наведено результати аналізу застосування пульмонологічної реабілітації згідно із спільними рекомендаціями Американського торакального та Європейського респіраторного товариств порівняно з даними в Україні. Запропоновано авторський підхід до захворювань та станів до застосування фізичної реабілітації як пульмонологічної складової в осіб з бронхолегеневими захворюваннями.
Динаміка антропометричних і біохімічних показників під впливом різних схем лікування у хворих на неалкогольну жирову хворобу печінки у поєднанні з ожирінням і патологією біліарного тракту
Authors: Filippova A. Yu.
Published: March 2023

Наведено результати власних досліджень, що відображають динаміку змін антропометричних і основних біохімічних показників у 100 хворих на неалкогольну жирову хворобу печінки у поєднанні з ожирінням і патологією біліарного тракту під впливом різних схем лікування. Встановлено сприятливий вплив кожного варіанта лікування на досліджувані показники. У разі комбінованого використання модифікації способу життя, стандартної терапії, урсодезоксихолевої кислоти та аргініну глутамату отримано більш виражене покращання антропометричних показників і функціональної активності печінки.
Клініко-нейрофізіологічні особливості перебігу спадкової моторно-сенсорної нейропатії і типу, зумовленої тандемною дуплікацією гена рмр22
Authors: Orzheshkovskyi V. V.
Published: March 2023

Наведено результати клініко-нейрофізіологічного дослідження 20 хворих віком від 20 до 56 років із спадковою моторно-сенсорною нейропатією (СМСН) І типу, яких розподілено на дві групи: І – 10 осіб з підтвердженою дуплікацією гена РМР22; ІІ – 10 осіб без дуплікації гена РМР22. Визначено відмінності в перебігу СМСН у хворих І групи в першу чергу у вигляді клініко-нейрофізіологічних ознак більш вираженого ураження нервів верхніх кінцівок та вторинної аміотрофії й маркерні електроміографічні показники для СМСН І типу з дуплікацією гена РМР22; зменшення амплітуди М-відповіді n. ulnaris та n. medialis, уповільнення швидкості поширення збудження по моторних нервах (n. medialis та n. ulnaris), а також збільшення резидуальної латентності n. ulnaris.
Лапароскопічна протезуюча герніопластика з використанням електрозварювальних технологій
Authors: Abu Shamsieh R. N. , Malcev V. M. , Dobrzhanskiy O. Y.
Published: March 2023

Методи лапароскопічної герніопластики відрізняються низьким рівнем травматизації тканин та достатньо високою ефективністю, що дозволяє даному методу бути альтернативою при проведенні герніопластики, тим самим зменшити післяопераційний больовий синдром та термін перебування пацієнта в хірургічному відділенні. Проведено ретроспективний аналіз 147 лапароскопічних оперативних втручань з приводу пахвинної грижі за методикою TAPP з використанням сітчастих імплантів різних моделей. При виконанні пластики проводили напівовальний розріз очеревини над латеральною та медіальною пахвинними ямками. Для фіксації поліпропіленових монофіламентних протезів використовували герніостеплери. Для відновлення очеревини над протезом в одних випадках використовували монофіламентний вікриловий шовний матеріал, в інших – електрозварювання м’яких тканин. У результаті лікування відмічали відсутність сером, гематом та хронічного пахвинного болю при використанні полегшених самофіксуючих протезів та відновлення цілісності шару м’яких тканин за допомогою електрозварювання. В інших випадках ускладнення були наслідком недостатнього гемостазу або недостатнього розміру сітчастого імпланту. Дана методика дозволяє зменшити матеріальні затрати на проведення оперативного втручання та сприяє популяризації лапароскопічних методик лікування даного захворювання.
Якісні та кількісні показники при дисплазії кульшових суглобів у дітей в до- та післярепозиційному періоді (за даними рентгенологічного дослідження)
Authors: Lysenko N. S. , Sharmazanova Ye. P. , Voronzhev I. A. , Korolkov A. I. , Protsenko V. V. , Iershov D. V. , Kramnoy I. Ye.
Published: March 2023

Вивчали кісткову структуру та рентгенограмометричні показники до і після хірургічного лікування дисплазії кульшових суглобів на основі аналізу рентгенограм 40 дітей віком 2–15 років. Після хірургічного лікування різні варіанти патологічних змін кісткової структури превалювали у дітей молодшої вікової групи. Рецидиви підвивиху та вивиху мали місце у 50 % пацієнтів з асептичним некрозом або вогнищами кістоподібної перебудови елементів суглоба; дані рентгенограмометрії значно відрізняються від нормальних значень у хворих з патологічними змінами кісткової структури.
The endogenous intoxication in workers exposed to lead
Authors: Karlova O. O. , Kuzminska O. V. , Trunina T. I. , Melnyk V. V.
Published: March 2023

The calculated indices such as leukocytic (LI), hematological (HI) and nuclear (NI) became the most commonly used in clinical practice to determine the endogenous intoxication. The aim of this study was to determine informativeness of the calculation methods for verification of the endogenous intoxication in workers depending on the content of lead in their blood. The calculated indices (nuclear, hematological and leukocyte) have been carried out in the blood of 146 workers exposure to lead, whose concentration in the air of the working area exceeded the maximum permissible concentration 1.4–1.8 times (study group) and 57 workers in the control group to study the parameters of endotoxemia. The index of reaction of a systemic response, sensitization index, an index of ratio between neutrophils and lymphocytes (IRNL) and an index of ratio between lymphocytes and eosinophils (IRLE) have been carried out in the blood sample of all workers to indicate the state of antitoxic adaptogenic system. The increase in Pb-K accompanied by statistically significant increase in the calculated indices of endogenous intoxication were detected for workers exposed lead. The endogenous intoxication characterized by changes in the calculated index leukocytic (LI), hematological (HI) and nuclear (NI) has been detected in workers exposed lead.
The Efficiency of Leadership Styles: The Socio-Psychological Aspect
Authors: Bykova I. M.
Published: March 2023

The study analyzed authoritarian and democratic leadership styles; identified and described social, psychological and personal factors affecting mental well-being of employees in the business organization. The psycho-correctional program and psychological recommendations for managers were elaborated. Within the frame of experimental research, methods aimed at studying leadership styles and their impact on psychological climate of organization were used. As a result of the study, the relationship between the dominant management style, the socio-psychological climate in the organization and the level of satisfaction within the context of work was revealed. The practical importance of the research is to develop and justify a psycho-correctional program aimed at facilitating the effective interaction between leaders and subordinates, reducing emotional tension within the team, establishing favorable psychological climate.
Etiopathogenetic bases of development of rehabilitation potential in patients with Rett syndrome
Authors: Koliadenko N. V. , Maltsev D. V. , Zhyvaho Ch. S. , Fedosova L. O.
Published: March 2023

The aim of the work is to present the results of studying the rehabilitation potential of patients with Rett syndrome and its etiopathogenetic foundations. The methodology of the study is based on an integrated approach to the development of etiopathogenetically substantiated treatment and rehabilitation techniques for diseases of the autism spectrum based on personalistic anthropology. Based on immunological studies, a role in the etiopathogenesis of Rett syndrome of herpesviruses due to immunodeficiency, genetically due to folate cycle failure, has been established. The expressed potentiating effect of high-dose intravenous immunoglobulin therapy on myelination / remyelination in the white matter of the cerebral hemispheres is proved, which makes Rett syndrome potentially curable. The leading role in cognitive and communicative activity of patients with Rett syndrome of auditory and visual analyzers has been established. On this basis, simulators have been developed to enhance the motivational component and the formation of purposeful attention. The originality (value) of this work consists in an innovative view of the etiopathogenesis of Rett syndrome as a genetically determined immunodeficiency herpesviral lesion of the central nervous system, as well as in demonstrating the presence of a significant rehabilitation potential in patients with this disease.
The paradox of the need-motivational sphere of people suffering from orthorexia nervosa
Authors: Lozova O. N. , Drobot O. V. , Fatieieva M. S.
Published: March 2023

The purpose of the study is to highlight the phenomenon of extremely common eating behavior disorder – orthorexia nervosa. The research is one of the first attempts at empirical study of the specifics of the genesis of orthorexia nervosa in contemporary Ukrainian society. The research was carried out during 2015–2016. The peculiarities of the sphere of needs and motivations of individuals with signs of orthorexia were empirically studied. The sample comprised 260 people, men and women of middle age, all residents of Kyiv. The methodological basis was provided by the following methods: “the method of pair comparisons by V. V. Skvortsov”; “Rome Questionnaire of Orthorexia Nervosa” (ORTO-15); “Multidimensional scale of perfectionism” questionnaire by Hewitt – Flett. А significant prevalence of orthorexia in contemporary Ukrainian society was noted (66.6 % of the subjects) during the study. It turned out that social needs were least important for respondents with orthorexia; more important were the need for security, self-actualization, and, most importantly – the need for self-affirmation. A direct connection was established between orthorexia, perfectionism and the need for self-affirmation and self-actualization. The results of the study proved that ORTO-15 questionnaire has its own limitations as a diagnostic tool, since it does not determine the tendency to orthorexia due to the influence of social environment and fashionable preferences. Diagnostic criteria for orthorexia, suggested by Morrows, also require further refinement. There is an urgent need for further study of this disorder, improvement of existing and invention of new methods of diagnosis of orthorexia, expansion of the range of research, as well as introduction of global experience of practical work with people with eating behavior disorders in contemporary Ukrainian practice of psychotherapy.
To the Question of the Displays of Fear and Anxiety among Children with Mental Retardation
Authors: Portnytska N. F. , Tychyna I. M.
Published: March 2023

The aim of the article is to study displays of children`s mental retardation. Сombination of research methods, which envisage the self –appraisal of emotional reactions, with an expert evaluation, allows carrying out integral description of displays of anxiety and fears of schoolchildren with mental retardation. Сhildren with mental retardation show an increase in the level of anxiety towards the end of primary school age and a slight decrease in its rates during the transition to secondary school. There are gender differences in the experience of anxiety, which are manifested at the level of content and intensity of fears in children with mental retardation. Limitation of the chosen methodology: low level of reflection and critical thinking of children with mental retardation during self-evaluation of anxiety and fears; subjective character of self-concept of own fears. Knowledge of age dynamics and gender peculiarities of the fears manifestation of children with mental retardation allows developing a complex of preventive and psychotherapeutic influences. The dynamics and gender peculiarities of anxiety and fears among schoolchildren with mental retardation are described in terms of studying at a boarding school.
The variability of the psychosocial development and the mental health of the personality during the juvenile nd the adolescent age
Authors: Shamne A. V.
Published: March 2023

The article deals with the issue of the mental health as a factor of the constructive psychosocial development of the personality. The favorable and unfavorable psychological factors are analyzed of the process of coming of age and the formation of the mental health of the present-day young people. In that context, the substance, the dynamics and the continuity of the individual variability of the psychosocial development of the individual during the juvenile and adolescent periods are discussed. The distinctive features of the mental health of young people are represented by the different variants of the psychosocial development (constructive, non-constructive and destructive). The relationships between the types of the psychosocial development and the forms of the mental health of juveniles and adolescents are determined. The main relationship can be found along the lines of constructive or non-constructive development, the focus on oneself or others, the reliance on oneself or the dependence on the milieu and circumstances. The factors of typing of the psychosocial development and the formation of the mental health are identified: the regulation by the personality of his/her behavior and activities and his/her position in the system of relationships. The presence of deformations of the mental health in the representatives of the non-constructive and the destructive psychosocial development is revealed. A comprehensive approach to the psychological support, forecasting and correction of unproductive paths of development and disorders of the mental health in the juvenile/adolescent age is presented.
Self-Disclosure as Indicator of Mental Health of Servicemen in the Conduct of Peacekeeping Operations
Authors: Dorichenko V. A.
Published: March 2023

In the practice and the theory of training modern Ukrainian soldiers there is no effective experience in supporting the civilian population in the zone of conducting peacekeeping operations. That is why studies that explicate aspects of the psychological training of servicemen for peacekeeping operations in the context of their mental health and positive impact on the civilian population are relevant. The material for writing the article was the work of a psychologist in the training courses for officers of civil-military cooperation, which has three main functions: assistance to the civilian population, organization of interaction with local authorities, international organizations and assistance to units of the Armed Forces.The article is devoted to the problem of identifying the main components of the psychological training of servicemen for peacekeeping operations.The article analyzes the views of scholars on such components of mental health as self-disclosure and its importance in the process of communication. The results of research of psychological peculiarities of self-disclosure of officers of civil-military cooperation are presented. The strategies to overcome stressful situations of officers are analyzed. An experimental study of the self-disclosure of officers was carried out for three years through the organization and conduct of trainings for military personnel. The courses were attended by 1200 participants. The empirical sample consisted of 30 officers (5 women and 25 men) of civil-military cooperation aged 30–45 years.
Psychological diagnostics of predisposition to addictive behaviour
Authors: Maksymova N. Yu.
Published: March 2023

Multidimensional manifestations of addictive behaviour complicate the possibility of its prevention. The purpose of our research is to determine the parameters diagnosing a person's predisposition to psychotropic substance use. We take as a point of departure the assumption that there are psychological peculiarities that are a kind of "weak link". Namely, these peculiarities determine the desire to change a person’s emotional state artificially. The experimental study of the parameters diagnosing predisposition to addictive behaviour has been performed by us for 15 years. Three groups with 90–100 adolescents in each were studied: well socially adapted adolescents – a "normative" group; socially maladapted adolescents who, however, did not use psychotropic substances; adolescents using psychotropic substances episodically. The study results show that the desire to use psychotropic substances is a symptom of a more general personal ill-being. Neutralization of negative personal formations prevents appearance of psychological readiness for psychotropic substance use.
Religiosity in nursing: The translation, validation and cultural adoption of the centrality of religiosity scale – 10 in Greek language
Authors: Fradelos Evangelos C. , Papathanasiou Ioanna V. , Kourakos Michael , Zyga Sofia , Tzavella Foteini , Tsaras Konstantinos
Published: March 2023

Religion has an important role in today’s society. Understanding religious perception and aspects of a person is a very complex process and could reflect ones moral values, cultural background and tradition. Many nurses around the world are religious and some religious motivations often prompt becoming a nurse. Aim of the study was the translation of the centrality of religiosity scale (CRS-10) in Greek language and the validation of the scale for the Greek population. The CRS-10 questionnaire is an anonymous self-administered questionnaire that contains ten, five point Likert scale, closed questions (ranging 1–5). The questionnaire was translated into Greek language and then back translated in the English in order to be checked for any inconsistencies. The sample of the study was 318 nurses and nurse assistants. Exploratory factor analysis, with principal components analysis was performed for checking the construct validity of the questionnaire. The test–retest reliability and the internal consistency were also examined. Statistical analysis performed by the use of SPSS 21.0. Statistical significance level was set at P = 0.05. The final Greek version of the questionnaire includes all of the ten questions. The mean age of the participants was (43.01 ± 7.60) years. One factor exported from the statistical analysis. The Cronbach-a coefficient was 0.919 for the total questionnaire. The CRS-10, is a valuable and reliable questionnaire that can be used for assessing religiosity in Greek population.