bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Avenues in Nutraceuticals and Pharmaceuticals from Algae
Authors: Ghosh Probir Kumar , Ghosh Chandrama
Published: May 2023

Background:

Alga (comprising of many varieties of algae) are our wealth from nature. They are abundant, and do not require any special sustenance measure; in fact, they sustain the fauna on Earth. Alga provide ‘nutritive’ and ‘ceutic’ functionalities, simultaneously. Their insignificant demand for sustenance, but the plethora of useful products they produce is intriguing. It’s also true that the im-pact of algae on our nutrition and pharmaceuticals is tremendous.

Objective:

Despite their utility, a coherent overview and an in-depth discussion on the various facets of alga as a source of nutraceuticals and pharmaceuticals is awaited. Currently, focus on specialization-wise utilization of algae is practiced by researchers, which could be owing to the lack of a review article that presents a comprehensive discussion on algal utilization in medicine and nutraceuticals. To know more about them functionally as a nutraceutical and pharmaceutical, a review article could provide a holistic understanding of algal utilization.

Method:

A narrative review for collation of findings, and developing an interlink among various find-ings has been adopted in the present article. This method was envisaged to better aid in understanding the lacunae in existing research, and formulate the way forward. The present disquisition focusses on discussing nutraceuticals and pharmaceuticals used or derived from alga that have significant utility.

Results:

The exposition provides an in-depth understanding on the developments that have been made, and attempts to apprise on the future scope available in the research for processes as well as products development, for the optimum utilization of this valuable bioresource. Compiling the article revealed that algal research has provided evidence-based insight into their utility spectra that establishes this botanical as a reliable bioresource for supplementation of food and medical care in the times to come.

Conclusion:

Interdisciplinary studies comprising botany, applied science, and product development should be envisaged as a futuristic strategy for algal product development, utilization, and commerciali-zation. This is because standalone approaches could not realize the complete potential of this biore-source. Future research could benefit from using various applications of algal products. Algal products' relevance is more realizable since the said botanical is both affordable and available in plenty (or at least be conveniently harvested). More inclusion of algae-based food products in our regular diet for functional attributes could be also considered as one of the useful outcomes of this review. Natural medicines based on algae could also be more consumed in the near future.
Economic Value of Mangrove Forest Ecosystem in Unit XXXIII Kubu Raya Forest Management Unit
Authors: Handayani Handayani , Roslinda Emi , Anwari M. Sofwan
Published: May 2023

Mangrove forest ecosystems resources could serve as income sources for the surrounding communities. However, the total economic value of these resourceshas yet to be recognized, calculated, and considered in managing and conserving mangrove forest ecosystems. This research aimed to estimate the direct economic value (timber, charcoal, aquatic biota, processed products, honey, and Nypa roof), indirect economic values (abrasion prevention, carbon stock, oxygen production, intrusion barrier), and optional economic value (biodiversity) of mangrove forest ecosystems. This research used two assumptions to calculate the total economic values: with and without timber utilization activities for charcoal production in the Unit XXXIII Kubu Raya Forest Management Unit (FMU). The results indicated that the indirect economic value had the highest percentages compared to the direct and optional economic values in both assumptions.
Sustainable Forest Management from Hydrology and Climate Change Mitigation Perspectives
Authors: Widiyatno Widiyatno , Asdak Chay
Published: May 2023

The increasing number of hydrometeorological disasters induced by unsustainable landscape management has led to significant fatalities and economic loss. Forest ecosystem landscapes are strategic national capital that could contribute to climate change mitigation. The government had formulated policies on Folu Net Sink ~2030  through sustainable forest management, environmental and carbon governance, and a Nationally Determined Contribution (NDC) strategic approach using its natural infrastructure in the form of forest ecosystem landscapes. The government could establish attractive and integrated incentive and disincentive systems and mechanisms with sustainable forest management to achieve the targets.
Analysis of Polynomial Time and Non-Polynomial Time of Algorithms
Authors: Saxena Vatsal
Published: May 2023

Abstract: The P vs NP problem is one of the most significant open problems in computer science and mathematics. This problem asks whether every problem that can be solved in polynomial time can also be verified in polynomial time. The purpose of this research paper is to explore the P vs NP problem and its relevance in the analysis of algorithms. We will discuss the techniques used to design and analyze algorithms, such as divide-and-conquer, dynamic programming, and greedy algorithms, and their relation to the P vs NP problem. We will also examine some examples of polynomial-time algorithms and NP-hard problems and analyze their time and space complexity, addition to which we will analyze the NP-Complete Problem and finally looking the current scenario of the P & NP and stating its significance.
Investigating Catalyzed Transesterification for Castor Oil Ethyl Ester Production: A Promising Biodiesel Substitute
Authors: Kumar Avinash
Published: May 2023

Abstract: This study investigates the catalysed transesterification method for producing castor oil ethyl ester (COEE), a biodiesel substitute. The research looks at a number of variables that impact the reaction, including temperature, the ratio of alcohol to oil, the concentration of the catalyst, the amount of mixing, and the purity of the reactant. In the experimental setting, biodiesel is created in a lab and tested on a diesel engine. The outcomes show that the transesterification procedure successfully lowers castor oil's viscosity and raises the fuel's cetane number. According to engine testing, a 20% blend of COEE demonstrates promising performance with conventional diesel fuel-like energy consumption and thermal efficiency. The study emphasises COEE's potential as a superior biodiesel alternative with viability.
Análisis de las condiciones para el fomento del turismo sostenible: cantón de Esparza, Costa Rica
Authors: Quirós-Aguilar Natalie
Published: May 2023

La investigación propuesta cumple como objetivo analizar las condiciones territoriales presentes en el cantón de Esparza de Puntarenas para el fomento del turismo sostenible como una herramienta útil para el desarrollo de las comunidades. La finalidad es describir algunas de las condiciones territoriales presentes en el cantón, que inciden en la actividad turística, y cómo estas afectan el desarrollo del turismo sostenible y pueden incidir en las comunidades locales. Para la recolección de información, se plantea el uso de entrevistas semiestructuradas y de la revisión documental para generar datos que se analizan desde la perspectiva de una investigación cualitativa de corte descriptiva y tipo transversal. Entre las principales conclusiones se destaca el interés de la población local por el desarrollo de emprendimientos turísticos de base comunal. Así mismo se recomienda promover acciones por parte de los empresarios turísticos locales, lo cual permite unificar esfuerzos en objetivos concretos, así como las iniciativas en la protección y la conservación de los recursos naturales.
The Moving Wave: Applications of the Mobile EEG Approach to Study Human Attention.
Authors: Mathewson Kyle , Kuziek Jonathan , Scanlon Joanna , Robles Daniel
Published: May 2023

While historically confined to isolated research laboratories,
electroencephalography (EEG) paradigms can finally be used in studies
involving walking and other complex behaviors. This transition from
isolated/immobile to unstructured mobile research can open new doors to
understanding attentional processes as they occur naturally. However,
there are current limitations in mobile EEG that must be overcome to
achieve great quality signals. We examine the feasibility of mobile
paradigms, including ecological validity, artifact correction
techniques, and methodological considerations. We review several mobile
studies related to attentional demands. This includes the replication of
robust effects like the P3 in mobile paradigms in our lab, studies using
walking, cycling, and dual tasking to study attention. We discuss how
the mobile approach compliments traditional laboratory paradigms while
it can add new dimensions to cognitive and attentional research. We
discuss promising applications of portable EEG in workplace safety and
other areas including road safety, rehabilitation medicine, and
brain-computer interfaces.
A unique approach to enhance catalytic performance of Lipase by in situ formation of silver nanoclusters
Authors: Ihsan Ayesha , Bukhari Syeda Zunaira , Aziz Faiza , Raza Ahmad , Bashir Saira , Jillani Asim , Zaheer Yumna , Hussain Syed Zajif , Hussain Irshad , Iftikhar Maryam
Published: May 2023

The purpose of this study was to design and engineer a simple approach
to enhance the catalytic activity and thermal stability of Lipase.
Lipase is an enzyme with exciting multifarious applications in the
industry. In this respect, we observed that the catalytic activity of
Lipase was enhanced when it was subjected to in situ synthesis of
silver nanoclusters (AgNCs) within the enzyme structure. At alkaline pH,
the in situ synthesis of AgNCs inside Lipase altered its
activity, and the resulting nanohybrid showed enhanced enzymatic
activity. Compared with the catalytic efficiency of free Lipase (72.33
min mM ), the Lipase clustered
with silver nanoclusters (L-AgNCs) showed enhanced catalytic efficiency
(109.22 min mM ). Thermodynamic
parameters of free Lipase and L-AgNCs were determined by calculating
activation energy (Ea) values to be 19.92 KJ mol-1 and 17.29 KJ mol-1,
respectively. The lower activation energy of L-AgNCs designates it to be
more stabilized and highly active to bind with the substrate having a
higher rate of reaction instead of free Lipase. Molecular docking
analysis showed that silver binds to amino acid residues of the Lipase
enzyme, which was also supported by the XPS analysis. Therefore, L-AgNCs
conjugate represented a novel Lipase preparation technique with
attributes of high activity and stability that could be an attractive
choice in diverse applications ranging from catalysis to diagnostics.
The overall study proposed an innovative strategy to improve enzyme
stability and catalytic activity.
Age and Diet Modulate the Insulin-Sensitizing Effects of Exercise: A Tracer-Based Oral Glucose Tolerance Test
Authors: Vieira-Lara Marcel A. , Reijne Aaffien C. , Koshian Serj , Ciapaite Jolita , Abegaz Fentaw , Talarovicova Alzbeta , van Dijk Theo H. , Versloot Christian J. , Bandsma Robert H.J. , Wolters Justina C. , Groen Albert K. , Reijngoud Dirk-Jan , van Dijk Gertjan , Bakker Barbara M.
Published: May 2023

Diet modulates the development of insulin resistance during aging. This includes tissue-specific alterations in insulin signaling and mitochondrial function, which ultimately affect glucose homeostasis. Exercise stimulates glucose clearance and mitochondrial lipid oxidation and also enhances insulin sensitivity (IS). It is not well known how exercise interacts with age and diet in the development of insulin resistance. To investigate this, oral glucose tolerance tests with tracers were conducted in mice ranging from 4 to 21 months of age, fed a low-fat diet (LFD) or high-fat diet (HFD) with or without life-long voluntary access to a running wheel (RW). We developed a computational model to derive glucose fluxes, which were commensurate with independent values from steady-state tracer infusions. Values for an IS index derived for peripheral tissues (IS-P) and one for the liver (IS-L) were steeply decreased by aging and an HFD. This preceded the age-dependent decline in the mitochondrial capacity to oxidize lipids. In young animals fed an LFD, RW access enhanced the IS-P concomitantly with the muscle β-oxidation capacity. Surprisingly, RW access completely prevented the age-dependent IS-L decrease; however this only occurred in animals fed an LFD. Therefore, this study indicates that endurance exercise can improve the age-dependent decline in organ-specific IS if paired with a healthy diet.

Article Highlights

Exercise is a known strategy to improve insulin sensitivity (IS), whereas aging and a lipid-rich diet decrease IS. Using a tracer-based oral glucose tolerance test, we investigated how exercise, age, and diet interact in the development of tissue-specific insulin resistance. Exercise (voluntary access to a running wheel) mainly improved IS in animals fed a low-fat diet. In these animals, exercise improved peripheral IS only at young age but fully prevented the age-dependent decline of hepatic IS. The prevention of age-dependent decline in IS by exercise is tissue-specific and blunted by a lipid-rich diet.
Vincent Van Gogh: A Negative Result from his Modern Suicidal Profile Assessment
Authors: Krier Leon
Published: May 2023

Killing Vincent Project (KVP) Team evaluates Vincent van Gogh’s ‘Suicide Profile’ while living in France, namely, Arles, St Remy Asylum, and Auvers-sur-Oise Profile utilizing the C-SSRS (Columbia – Suicide Severity Rating Scale). This evaluation of Van Gogh indicates that there were some risks factors and concerns for suicide in Arles and St Remy Asylum; however, while living in Auvers-sur-Oise, the C-SSRS evaluation reinforces that Van Gogh was living an extremely productive artistic life, doing a painting a day with breakthrough originality. There were no further vertigo attacks; he expressed no suicidal ideation nor gestures or self-injurious behavior. While in Auvers-sur-Oise, Van Gogh had become emotionally settled, found love, and was becoming a recognized breakthrough artist. KVP’s C-SSRS evaluation indicates a ‘negative suicidal profile assessment’ in his last 70 days. Therefore, it is reasonable to conclude: Vincent van Gogh did not commit suicide.
Identification of Ivory Using a Handheld XRF Spectrometer
Authors: O Espinoza Edgard
Published: May 2023

Handheld XRF can be used as a screening tool, allowing rapid elemental analysis of materials in-situ. In this study, 280 ivory samples from 7 different species and 20 bone samples from 15 species were analyzed using a SciAps X-50 handheld XRF spectrometer. The data collected were used to establish a light element (LE) percentage range of 50.3% to 75.5%, and a calcium (Ca) percentage range of 24.5% to 49.5%. All ivory samples fall within these ranges, which represent the overall variation observed in ivory. Additionally, the XRF device was used to analyze the elemental composition of 123 samples from 10 biological and nonbiological material types frequently used as ivory substitutes (i.e, ivory look-alikes). The results showed that all look-alike values, except for bone, fall outside the experimental ranges established for ivory. Moreover, some materials have higher concentrations of other elements not present in ivory, such as titanium (Ti). The composition of bones was similar to ivory and could not be distinguished from ivory using this method alone. A significant difference in LE and Ca proportions was observed between cementum and dentin tissues in ivory from elephant. However, this difference falls within the overall variation when all species are considered. Multivariate analysis showed that species of origin of ivory samples could not be determined using this method. Six (6) blind validation samples were analyzed and correctly classified as ivory or substitutes using the established ranges. Our conclusion is that handheld XRF analysis can effectively assist in identifying genuine ivory and ivory look-alike materials, along with traditional morphological analysis, especially when Schreger lines are not visible on small carved objects.
Diatomological Profile at Discrete Depths of Powai Lake, Mumbai for Medico-Legal Purposes
Authors: Sahajpal Vivek
Published: May 2023

Diatoms are photosynthetic microorganisms that play important role in forensic diatomology in the diagnosis of drowning deaths. In the present study, the Diatomological profile of Powai lake was prepared for medico-legal purposes using the Shannon-Wiener index. Powai lake (19.1266° N, 72.9062° E) is a large artificial lake situated in a northern suburb of Mumbai. Diatoms sampling was conducted in February 2017 from this lake. This study aimed to identify the various genera of diatoms and to determine the relative abundance, generic counting, and diversity index of diatoms for the medico-legal purposes. Littoral benthic diatoms of five locations were sampled from this lake. Diatoms slides were prepared by scraping the rock surface with an area of 3x3 cm, diluting in 50 ml distilled water, and identification under the microscope with 1000 magnification. Identification of 17 genera of diatoms was done using the web-based visual guide ‘Diatoms of the United States’. Diatoms belong to both the orders Centrales and Pennales. The pH of the lake water was found to be 7.64 i.e. slightly alkaline and the temperature was 27°C. Water quality parameters showed a fairly good value for the growth of diatoms. Samples were dominated by class Bacillariophyceae, which included 9 genera followed by Coscinodiscophyceae, with 6 genera, and Fragilariophyceae, with 2 genera. Generic counts of diatoms were obtained by using the ‘Neubauer’ Counting chamber. The Shannon-Wiener diversity index (H') ranges from 1.042 in Epipelic to 0.454 in Emerged Epiphytic diatoms. The purpose of this study was to prepare a diatomological profile of diatoms at discrete depths for medico-legal purposes.
PENGEMBANGAN BUKU CERITA BERGAMBAR UNTUK MENANAMKAN NILAI KARAKTER DISIPLIN BAGI SISWA KELAS I SEKOLAH DASAR
Authors: Megawati S. , I.W. Lasmawan  , I.K. Gading
Published: May 2023

Penelitian ini bertujuan untuk mengembangkan dan menghasilkan produk berupa buku cerita bergambar untuk menanamkan nilai karakter disiplin bagi siswa kelas 1 sekolah dasar yang acceptability. Penelitian ini merupakan penelitian pengembangan (R&D) model ADDIE. Data yang dikumpulkan pada penelitian ini berupa dataacceptability (keberterimaan) yang meliputi utility (kegunaan), feasibility (kelayakan), dan accuracy (ketepatan)penggunaan dari produk yang dikembangkan.Data penelitian dikumpulkan dengan menggunakan angket. Data yang terkumpul kemudian dianalisis secara deskriptif kuantitatif. Hasil dari penelitian ini menunjukkan bahwa, (1) Karakteristik buku cerita bergambar untuk menanamkan nilai karakter disiplin yaitu: a) buku berukuran A4 (210 mm x 297 mm) dengan font san-serif Andika New Basic; b) menggunakan tokoh manusia dengan nama tokoh utama Putu dan Made; c) judul buku “Ingin Menjadi Siapa?”; dan d) anatomi buku terdiri dari cover, halaman prancis, identitas penulis dan badan naskah. (2) Hasil uji keberterimaan (acceptability) dapat dijabarkan sebagai berikut. a) Hasil uji utility sebesar 95,00% berada pada rentang 81%-100%. Ini berati bahwa buku cerita bergambar memiliki nilai utility sangat baik; b) Rata-rata persentase hasil uji feasibility sebesar 93,00% berada pada rentang 81%-100%. Ini berati bahwa buku cerita bergambar memiliki nilai feasibility sangat baik; dan c) Rata-rata persentase hasil uji accuracy sebesar 97,00% berada pada rentang 81%-100%. Ini berati bahwa buku cerita bergambar memiliki nilai accuracy sangat baik. Berdasarkan hasil uji acceptability yang meliputi yaitu kegunaaan (utility), kelayakan (feasibility), dan ketepatan (accuracy) berada pada kategori sangat baik. Simpulan penelitian menunjukkan bahwa telah dihasilkan buku cerita bergambar untuk menanamkan karakter disiplin bagi siswa kelas 1 sekolah dasar yang acceptability.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK DIGITAL BERORIENTASI PEMECAHAN MASALAH PADA PEMBELAJARAN IPA SISWA KELAS V SD
Authors: N.L.I. Noviani  , I.M. Candiasa  , I.G. Margunayasa
Published: May 2023

Penelitian ini bertujuan untuk mengembangkan LKPD digital berorientasi pemecahan masalah pada pembelajaran IPA siswa kelas V SD. Penelitian ini menggunakan model  pengembangan 4-D yang terdiri dari empat tahap utama yaitu define, design, develop, dan disseminate. LKPD yang dihasilkan sudah diuji validitas isinya oleh ahli yang hasilnya dianalisis dengan formula Gregory dan diperoleh koefisien validitas isi sebesar 1,0 dalam kategori valid. LKPD yang dihasilkan dinilai oleh 2 ahli materi pembelajaran, 2 ahli desain, dan 2 ahli media menggunakan LORI (Learning Object Review Instrument). Hasil kelayakan materi ahli pertama 97% dalam kategori sangat layak dan ahli kedua 99% dalam kategori sangat layak, kelayakan media ahli pertama 97,14% dalam kategori sangat layak dan ahli kedua 100% dalam kategori sangat layak, dan kelayakan desain ahli pertama 100% dalam kategori sangat layak dan ahli kedua 100% dalam kategori sangat layak. LKPD digital sudah diujicoba pada 2 sekolah, yaitu di SD No. 1 Seminyak dan SD No. 3 Legian melalui daring. Pada tahap uji coba dilakukan uji efektivitas dan efisiensi. Hasil yang diperoleh adalah 100% siswa tuntas, sehingga media dinyatakan efektif. Sementara itu, uji efisiensi mendapatkan skor 4,89 berada pada kriteria sangat tinggi.
PENGEMBANGAN INSTRUMEN SELF REGULATED LEARNING DAN KECERDASAN EMOSIONAL PADA PEMBELAJARAN MATEMATIKA KELAS V SEKOLAH DASAR
Authors: I.W.A. Parantika  , Sariyasa  , I.G. Astawan
Published: May 2023

Penelitian ini bertujuan untuk  menilai  self regulated learning dan kecerdasan emosional pada pembelajaran matematika kelas V di sekolah dasar. Jenis penelitian menggunakan penelitian pengembangan yang dikemukakan oleh Djmari Mardapi. Pengembangan ini terdiri dari 7 tahapan yaitu : (1) Menyusun spesifikasi tes/non tes, (2) Menulis soal tes/non tes, (3) Menelaah tes/non tes, (4) Memperbaiki tes/non tes, (5) Melakukan uji coba, (6) Menganalisis tes/non tes, (7) Menafsirkan hasil tes/non tes. Bentuk instrumen yang dikembangkan berupa kuisioner. Berdasarkan hasil penelitian menunjukkan bahwa : (1) Hasil perhitungan  CVR  instrumen self regulated learning  diperoleh 29 instrumen yang valid dengan nilai CVI sebesar 0,98. (2) Hasil perhitungan  CVR  instrumen Kecerdasan emosional   diperoleh 29 instrumen yang valid dengan nilai CVI sebesar 0,98. (3) Hasil uji reliabilitas instrumen self regulated learning   diperoleh hasil 0,847 yang artinya sangat reliabel, (4) Hasil uji reliabilitas instrumen kecerdasan emosional diperoleh hasil 0,852 yang artinya sangat reliabel.
EFEKTIVITAS E-MODUL BERBASIS CATUR PRAMANA PADA PEMBELAJARAN IPA UNTUK MENINGKATKAN HASIL BELAJAR
Authors: L.P.C. Dewi  , D.P. Parmiti  , I.G. Astawan
Published: May 2023

Penelitian ini bertujuan untuk  (1)  mengetahui validitas E- Modul   Berbasis Catur Pramana Pada Pembelajaran IPA, (2) mengetahui  kepraktisan E- Modul   Berbasis Catur Pramana Pada Pembelajaran IPA dan (3) mengetahui efektivitas E- Modul   Berbasis Catur Pramana Pada Pembelajaran IPA. Subjek penelitian adalah  6 orang ahli  yang terdiri dari ahli media, materi, bahasa untuk menguji validitas produk, guru sebanyak 4 orang menguji kepraktisan produk dan siswa 35 orang siswa menguji kepraktisan dan efektivitas produk. Metode pengumpulan data kuesioner dan kepraktisan serta tes hasil belajar untuk efektivitas. Instrumen pengumpulan data pada kuesioner terdiri dari; instrumen media, materi, ahli bahasa, dan instrumen hasil belajar berupa tes pilihan ganda. Analisis data dekriptif kuantitatif dan kualitatif. Jenis penelitian ini adalah penelitian pengembangan. Adapun produk yang dihasilkan berupa E-modul berbasis Catur Pramana dengan menggunakan model ADDIE. Adapun hasil penelitian pengembangan sebagai berikut (1) validitas E- Modul   Berbasis Catur Pramana Pada Pembelajaran IPA yaitu meperoleh hasil validitas melalui ahli materi 98,59% sangat valid, validitas ahli media 95,63% sangat valid, skor validitas ahli bahasa 94,28% sangat valid. (2) Keprktisan validitas E- Modul   Berbasis Catur Pramana Pada Pembelajaran IPA yaitu meperoleh hasil oleh praktisi guru yaitu sebesar 100% sedangkan persentase hasil uji coba kelompok kecil oleh siswa yaitu sebesar 95,55% dan (3) efektivitas  E- Modul   Berbasis Catur Pramana Pada Pembelajaran IPA menunjukan bahwa hasil belajar IPA Siswa meningkatan dengan skor rata-rata sebelum menggunakan E-Modul yakni 70,00 dan sesudah menggunakan E-Modul adalah 89,60.
The Learning Media Application "BELIPARU" Oriented Towards the Mastery of Fifth-Grade Students' Concepts of the Water Cycle Material
Authors: Fanny Destiani  , Atep Sujana  , Ani Nur Aeni
Published: May 2023

The low level of mastery of concepts by elementary school students in Indonesia, especially in science subjects, impacts students' low learning outcomes and enthusiasm for participating in teaching and learning activities. So to maximize the learning process, teachers must start utilizing the use of media. This study aims to see the effectiveness of the "BELIPARU" application media, which is oriented towards mastering the concept of fifth-grade students. This research belongs to the type of development research developed using the Borg and Gall model, with four research stages consisting of the idea gathering and reference stages, product manufacturing stage, media validation stage and material validation stage, product revision stage, and trial stage. The test subjects were conducted on 29 students in class V. This data collection method was carried out through observation, written test instruments in the form of pretest and post-test questions, and closed questionnaires for students. The data obtained in this study were then analyzed using descriptive-quantitative analysis techniques through the SPSS application, which were then thoroughly described using descriptions. The research analysis showed that the media expert test produced a percentage of 92.5% in the very good category. In comparison, the results of the material experts produced a percentage of 90.6% in the very good category, although there was a slight minor revision in the validator. Furthermore, the results of the pretest activity trials showed an average of 22.24, and the results of post-test activity testing showed an average of 64.31. Based on these results, Android-based applications are very suitable for students' learning process, especially in increasing mastery of concepts.
Educational Game-Based Thematic Learning Media to Improve Student Learning Competence
Authors: Haloho Yenni mesilina , I Kadek Suartama  , I Komang Sudarma
Published: May 2023

The limitations of interesting learning media on thematic subjects impact low student learning competence. To improve student learning competence, digital learning media is needed that is easy for students to access. This study aims to develop educational game-based thematic learning media to improve the learning competence of grade IV students. This research is developmental research using the Hannafin & Peck model. The research subjects were one content expert, one design expert, and one learning media expert, then three individual trials, six small group trials, and fifteen field trials. Data collection in this study was carried out using questionnaires and tests, with research instruments in the form of product validity test questionnaires and student learning outcomes tests. The data obtained in the study were then analyzed using quantitative descriptive analysis techniques and qualitative descriptive analysis methods. The research analysis results showed that the products developed were valid based on the results of content experts obtained at 95.50%, learning design experts obtained at 88.00%, learning media experts at 94.67%, individual trials at 92.67%, small group trials at 95.17%, and field trials 95.70%. Based on these results, it can be concluded that developing educational games in thematic subjects in class IV is classified as a very good qualification and is declared suitable for use in the learning process.
Seasonal Variation of the Ecological Water Quality in a Drinking Water Supply Dam Lake in Bongouanou (Côte d’Ivoire)
Authors: Kouadio Nathalie Akissi , Aboua Danielle Rose Benié , Yao Stanislas Silvain
Published: May 2023

The Ichthyological Index of Wetlands (IIW), for the monitoring of the water quality of Ehuikro Lake in Bongouanou, was established. Monthly, experimental gillnet fisheries were conducted between July 2017 and June 2018 in Lake Ehuikro (Bongouanou, Ivory Coast). The fish collected were identified and counted each month, as well as the physicochemical parameters measured in-situ. A partial canonical correspondence analysis (pCCA) was used to order fish species along the axes according to physicochemical parameters to explain anthropogenic disturbances. It appears from this analysis that the water of Lake Ehuikro is of "good quality" during the rainy season and of "poor quality" during the dry season.
The Begawan Ciptaning scene in the Gagrag Ngayogyakarta puppet show: Representation to approach the self to the essence of the God
Authors: Sulaksono Djoko , Fitriana Tya Resta , Veronika Prima
Published: May 2023

Puppet stories or shows are literary works that contain didactic moral problems and aesthetic elements. Puppet shows also contain extensive guidelines (piwulang), such as religious values, philosophy, ethics, and character education for human life. Furthermore, the puppet has noble values ​​as role models and illustrations of daily human life (pathet) and crucial to build character and national identity. This study aims to describe and elaborate on the philosophical meaning of the Purwa Puppet of Gagrag Ngayogyakarta style performance, especially the scene of Arjuna’s asceticism or Begawan Ciptaning. This research is a qualitative descriptive study. Data analysis techniques using content analysis. The results of this study indicate the role model of Arjunawiwaha’s story, especially the scene of Arjuna’s asceticism. This scene contains moral values, such as Arjuna’s firmness and persistence in trying to get closer to the essence of the world’s rulers. Another value is devotion to parents and the state, and leadership. The values found in the puppet stories are also relevant to nowadays life and are linked to Islamic thoughts.
MODERN TRENDS IN PHOTON RADIATION THERAPY IN PEDIATRIC PRACTICE
Authors:   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Nechesnyuk A.V. , Loginova A.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Rumyantsev A.G. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
Published: May 2023

New technologies in radiation therapy (RT) are rapidly developing and entering the clinical practice of leading clinics. Pediatricians, pediatric oncologists, hematologists and other physicians are in need of understanding of the main trends in the development of modern RT in pediatric practice. The Article describes the main modern methods of photon radiation therapy (PRT) and of RT with intensity modulation and image control in particular, considers the methods of adaptive and stereotaxic RT. The urgent need for a reference evaluation of irradiation of pediatric patients’ plans is demonstrated as well. Thus, according to the reference evaluation results of 270 plans from 40 clinics, it was found that gross errors in target contouring were found in 39% of cases, the plan that could not be accepted for treatment in 40%. Modern PRT has wide technological capabilities, however, for its more effective use for the benefit of patients it is necessary to create a unified national database of RT plans. Only an analysis of the new data can make it possible to take more balanced approach to planning exposure in children, to provide dose reduction/escalation in patients of various prognostic groups taking into account the likelihood of undesirable late effects.
HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN RELAPSED CENTRAL NERVOUS SYSTEM TUMORS: CHALLENGES AND RESULTS
Authors:   Research Laboratory of Pediatric Neurology, Immunology and Oncology of the World-Class Research Center “Center for Personalized Medicine” with the V.A. Almazov National Medical Research Center of the Ministry of Healthcare of Russia, Saint Petersburg, Russia, Dinikina Y.V.
Published: May 2023

Intensification of antitumor treatment using high-dose chemotherapy (HDCT) with autologous hematopoietic stem cell transplantation (aHSCT) has been an effective option for many years in a number of nosological forms of central nervous system (CNS) tumors in children as the first-choice therapy. However, its benefits in relapsing forms of the disease are not obvious, which has led to ongoing discussions. Studies on the comparative efficacy of HDCT in recurrent CNS tumors are few. The heterogeneity of the studied patient cohorts should be noted additionally, which in its turn does not allow reaching a consensus on indications for its use. The Article represents current bibliographical data on the use of HDCT with aHSCT in pediatric patients with relapses of various nosological forms of CNS tumors in terms of its possible effectiveness and toxicity.
CERVICAL THYMUS ECTOPIA IN CHILDREN
Authors:   Russian Children's Clinical Hospital with the Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow, Russia, Kugushev A.Yu. , Lopatin A.V. ,   Russian Children's Clinical Hospital with the Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow, Russia, Grachev N.S. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Kletskaya I.S. ,   Russian Children's Clinical Hospital with the Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow, Russia, Starokokova K.D. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
Published: May 2023

Thymus ectopia is a rare solid neck lesion in children. The location of the formation along the path of thymus migration (thymopharyngeal duct), the echo pattern and the intensity of the MR signal, which is identical to the normally developed thymus, help in making a confident diagnosis. Materials and methods of the research: 14 pediatric patients were treated against the cervical thymus ectopia in 2018-2022 in the Russian Children's Clinical Hospital with the Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia and the National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev (both located in Moscow, Russia). The diagnosis was set only after the histological examination results in all cases. A differential diagnosis was made with other cystic and solid formations, taking into account its location and distribution according to ultrasound, computed tomography, and magnetic resonance imaging in each case. Results: stable, relapse-free treatment result was achieved after more than a year of follow-up in all cases. The correct diagnosis wasn’t set in every case until the biopsy results due to the rarity and diverse clinical and radiological picture of the disease. Conclusion: cervical thymus ectopia is a benign and relatively rare condition in children that is rarely diagnosed preoperatively by the visualization only. The conservative management may be appropriate in some cases when the thymus is in the chest cavity only, but surgical correction is more often needed in cases with the neck deforming formations.
ANALYSIS OF SOME FACTORS AFFECTING THE TEMPORARY TEETH ERUPTION
Authors:   Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia, Balafendieva F.M. , Kiselnikova L.P. ,   Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia
Published: May 2023

Purpose of the research was to study the frequency of occurrence of the temporary teeth eruption syndrome and the influence of some factors on its manifestations. Materials and methods used: children aged 4 months to 2 years and 5 months old living in the North-East Administrative Okrug of Moscow with health profile I, II groups who applied with symptoms of undesirable local and general manifestations of temporary teeth eruption were examined in 2022 on the basis of the Moscow City Children's Polyclinic No. 125 of the Moscow Department of Healthcare (Moscow, Russia) as part of preventive dental examinations. Results: during dental examinations of 250 children with symptoms of temporary teeth eruption it was revealed that only 214 (86%) were diagnosed with teething syndrome (ICD-10 K00.7). A statistically significant relationship was found between the incidence of difficult temporary teeth eruption and deviation from the average body weight (BW) at birth in children with low and high BW (R^2=0.836, p<0.001; R^2=0.880, p<0.001). Analysis of the nature of children feeding and the frequency of occurrence of difficult temporary teeth eruption showed statistically significant relationship in children who were bottle-fed (R^2=0.987, p<0.001) and mixed-fed (R^2=0.971, p<0.001). Conclusion: the results of a clinical study of children confirm the high incidence of difficult teeth eruption as well as the effect of birth weight and the type of feeding on the incidence of difficult teeth eruption.
Langerhans cell histiocytosis in twins: bibliographical review and clinical case
Authors:   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Fominykh V.S. , Batmanova N.A. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Valiev T.T. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Nazarenko I.A. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Kirgizov K.I. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, Varfolomeeva S.R. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Published: May 2023

Langerhans cell histiocytosis (LCH) is the most common histiocytic disorder in children and is characterized by clonal expansion of myeloid precursors. The pathological cells are morphologically and phenotypically similar to Langerhans cells. LCH is considered as a sporadic disease as yet with undescribed hereditary factors for its development. However, hereditary predisposition to the development of this pathology cannot be excluded. There are cases of the LCH development in twins described, both in monozygotic and dizygotic. Article represents bibliographical review on the familial forms of Langerhans cell histiocytosis and clinical case of the Langerhans cell histiocytosis development in twin girls.
SCORING SYSTEM FOR EVALUATING INDICATIONS FOR WIDE EXCISION OF SPITZ/REED NEVUS IN CHILDREN AND ADOLESCENTS
Authors:   N.N. Petrov National Medical Research Center for Oncology, Saint Petersburg, Russia, Kulyova S.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Khabarova R.I. ,   N.N. Petrov National Medical Research Center for Oncology, Saint Petersburg, Russia
Published: May 2023

This research was aimed to developing the scoring system for evaluating indications for wide excision of the Spitz/Read nevus in children and adolescents, the use of which would be of help in reducing the risk of underdiagnosis of skin melanoma and determining the management tactics of patients with spitzoid formations. The purpose of the research was to create a scoring system for evaluating indications for wide excision of the Spitz/Reed nevus in children and adolescents. Materials and methods used: a single-center (N.N. Petrov National Medical Research Center for Oncology, Saint Petersburg, Russia) retrospective (2016-2022) cohort study included 65 childhood and adolescent patients with skin neoplasms of melanocytic and vascular origin. Clinical and dermatoscopic examinations of the skin neoplasm were performed at the pre-invasive stage, which was then followed by its removal and morphological verification. The study group consisted of children and adolescents aged 0 to 18 y/o (median age 14 (12.0; 15.0) y/o) with complex (n=22 or 33.8%), dermal (n=30/46.1%), blue (n=2/3.1%) nevi, Spitz/Reed nevus (n=4/6.2%) and capillary-lobular hemangioma (n=7/10.8%) Results: correlation analysis of 77 factors characterizing the demographic, clinical and dermatoscopic patterns had allowed the Authors to identify signs that are statistically significantly correlated with the Spitz/Reed nevus variable. In the block with demographic data parameters, the main position was occupied by the patient’s age of over 11 y/o (p˂0.001); formation area ≥0.38 cm2 (p=0.010) topped in the block with clinical examination parameters; and starburst pattern (p=0.003), irregular borders (p˂0.001), white-blue veil (p˂0.001), multicomponent (p=0.001), reticular network (p˂0.001), globules (p˂0.001) and vascular structures in the form of a comma (p˂0.001) among dermatoscopic ones. The value of the prognostic coefficient determined the score of each factor, which contributed to the selection of large and small patterns. The gradation of the sum of scores of the identified predictors made it possible to create a scoring system for analyzing indications for wide excision of the Spitz/Read nevus in children and adolescents and to develop a practical BASE-SCRAG scale. The sensitivity of the scale was 100%, the specificity was 62% (95% CI 57-64%). Conclusions: the Spitz/Reed scoring system for evaluating indications for wide excision of a nevus and the BASE-SCRAG practical scale contribute to the stratification of pediatric and adolescent patients in the group for possible dynamic observation and the group of mandatory removal and verification of the pathological skin process.
The Challenges of CEFR adoption: Teachers’ understanding and classroom practice
Authors:   Pusat Asasi, Universiti Teknologi MARA, MOHAMAD URI NURUL FAREHAH
Published: May 2023

CEFR has been extensively adopted in many countries including Malaysia. Currently at the third phase of the implementation, the concept of CEFR and the applicability is not new to most teachers. Over the years, numerous local studies have been conducted to discover the real situation faced by both teachers and students who are directly affected by the government’s decision to replace the previous syllabus with the new CEFR aligned English syllabus. This study was conducted with the objectives of investigating the challenges encountered by English teachers on understanding CEFR and the potential challenges faced by the teachers in CEFR classroom practice in the adoption process. A panel member of the English Language Standard and Quality Council (ELSQC) and 331 school teachers participated in this study. Survey and in-depth interview were employed for data gathering. Computer software such as NVivo and SPSS were used for data analysis. Results show that most teachers lack understanding especially on the adoption of the framework. Moreover, classroom practice is a real challenge to the teachers because the imported CEFR-aligned textbooks are causing additional workload due to adapt them to the local context. Preparing and designing their own CEFR aligned teaching materials based on the new syllabus is another challenge of classroom practice for the teachers.
CONTRIBUTION OF ISLAM IN THE WORLD (Case Study of Islamic Education Transmission)
Authors: Thulfitrah B. Nurlathifah
Published: May 2023

Talking about the civilization of western, of course, it cannot be separated from the old history of Islam and the peak of its civilization. Before the power of science raised the spirits of western people who gave birth to the renaissance, Islam had experienced its golden age, while Europe was confined by the dark age. It reads a terrible condition, which Islam is busy with scientific studies so that it gives a civilization that has a very high value, unlike the western which closes rationality and relies on mystical. The spirit of moderation, liberation, and tolerance built by muslims, made westerners who chose to leave the old age free from pressure to make intellectual contact with muslim scholars. It is noted that they helped Islam a lot in translating Greek books into Arabic and translated by westerners into Latin. If you look closely, there is a common thread to connect these two different Qiblas. Muslims who reached the peak of glory in the Middle Ages, of course there was “interference” from other nations, such as the western. On the other hand, advanced western nations cannot be separated from the great contribution—consciously or unconsciously—by muslims in the past. Therefore, it is deemed necessary to recall Islam and its great contribution to the western world through Islamic education.
THE EFFECT OF ACADEMIC PROCRASTINATION ON LEARNING ACHEIVEMENT OF ISLAMIC RELIGIOUS EDUCATION STUDENTS AT SMAN 5 MAKASSAR
Authors: Makbul M , Miftahuddin Miftahuddin , S Dewi Saputri. , Ismail Ahmad La Ode
Published: May 2023

This study aims to (1) determine the level of academic procrastination in students at SMA Negeri 5 Makassar (2) to determine the learning outcomes of students at SMA Negeri 5 Makassar (3) to determine the effect of academic procrastination on student learning outcomes at SMA Negeri 5 Makassar. This type of research uses the expost facto method where academic procrastination is the independent variable and learning outcomes are the dependent variable. The total population in this study was 936 students and the sample taken was 91 students. The research instrument used in this research is a questionnaire (questionnaire) and documentation. The processing and analysis techniques used are descriptive statistical analysis and inferential statistical analysis. Based on the results of processing academic procrastination variables, it can be concluded that academic procrastination has a significant effect on student learning outcomes in Islamic Religious Education and Budi Pekerti lessons. For students at SMA Negeri 5 Makassar in order to improve learning outcomes by reducing the habit of academic procrastination (the habit of procrastinating), and increasing achievement motivation so that they dare to face tasks with full responsibility.
ولي النكاح من منظور الحديث: بحث موضوعي
Authors: Ahmad La Ode Ismail , Amrah Darul Aqsa , Tonang Muhammad
Published: May 2023

يتناول هذا البحث تفصيلا تحليلاً لولي النكاح بحدة شفرة الحديث، حيث أن الولاية في النكاح شرط لصحته، فحضور الولي يعطي شرعية صحة النكاح، ومن منظور الحديث ثمة حجتان تقدمان إرشادات حول ولي النكاح، وهي الأحاديث العامة التي تقدم وصفًا بأنه لا زواج بدون حضور الولي، والأخرى أحاديث خاصة تقدم رخصا بدون حضور الولي إذا كانت المرأة ثيبة أو أرملة، وهذا يدل على أن الأرامل اللاتي بلغن ذروة النضج وذقن حياة زوجية يمكنهن إجراء عملية الزواج دون حضور ولي الأمر.