bluuebunny/crossref_metadata_2025 huggingface dataset:
Social protection of family members of military personnel in Ukraine: problems and ways to solve them
Authors: Sydorenko A.O.
Published: February 2023

The article is devoted to the study of the peculiarities of the legal regulation of social protection of members of military servicemen's families in Ukraine, the analysis of problematic issues of such protection and the introduction of proposals on ways to solve them. It is noted that the primary task of the state is to ensure social protection of its population and create conditions for a sufficient standard of living of people in the state. Because the right to social protection is one of the most important rights of a person, which must be recognized and guaranteed at the state level. It is noted that the category of the population in need of special social protection includes military personnel, whose activities are directly related to danger to life, and members of their families. Especially today, in the conditions of armed aggression, economic instability and the systematic and planned transformation of Ukraine as a European model state, the issue of social protection of military personnel and their family members is quite acute. It was concluded that in order to improve the social situation of family members of military personnel, it is necessary to improve their social protection. In particular, amendments to the laws of Ukraine and other normative legal acts in various areas, including improving the legislation on the strengthening of social protection for members of military servicemen's families; bringing the level of material and other types of security in line with the rights and freedoms established for them by law. Since the social protection of both military personnel and their family members, maintaining their lives at an appropriate level, is an important part of the social policy of the state, which is responsible for the well-being, development and security of its citizens. The social and legal protection of family members of military personnel is proposed to be understood as the activity of the state aimed at establishing a system of legal and social guarantees that ensure the realization of constitutional rights and freedoms, the satisfaction of the material and spiritual needs of family members of military personnel in accordance with the special type of their legal status in society.
Legal relations in the field of labor and employment related to the creation and use of intellectual property objects
Authors: Sova V.
Published: February 2023

The article is devoted to clarifying the current scope and structure of legal relations in the field of labor and employment, within the framework of which an employee creates and uses intellectual property objects. It is established that these relationships are divided into two main types. Firstly, such relations are labor relations, such as the relationship between an employee and an employer, in which employees create and use intellectual property objects. It is proven that individual labor relations are the main legal context in which intellectual property objects are created and/or used by an employee. As for collective labor relations, they are derived from individual legal relations and affect the process of regulating such relations at the local level. Secondly, a separate type of legal relations under consideration are relations of an organizational, industrial, and managerial nature, involving the creation and/or use of an object of intellectual property in labor relations. This type of legal relationship is also derived from individual labor relations and is divided into three main subtypes. First of all, it is the relationship between the employees who make up the group that creates and/or uses the intellectual property object. In addition, it is the relationship between the employees who make up the group that produces and/or uses the intellectual property object and the employer. It is also a relationship between a representative of the employer and a group of employees who create and/or use an intellectual property object and the employer's client. In the article's conclusion, it is stated that the relationships in which intellectual property objects are created and/or used by an employee have two main practical manifestations. First, there are the most basic relations – individual labor relations (between an employee and an employer). Secondly, these are derivative relations – other legal relations that condition, complement, and contribute to the proper implementation of individual labor relations in which an employee independently (or jointly with other employees) creates and uses intellectual property objects.
Agricultural insurance under martial law: problems of legal regulation and challenges of the future
Authors: Klierini H.V.
Published: February 2023

The article is devoted to the study of the legal framework for insurance of agricultural products, taking into account the specifics of the introduction of martial law in Ukraine, establishing the role of the state in the process of financial support of agricultural insurance entities, as well as identifying potential crisis phenomena that may adversely affect the development of agribusiness in the future. The object composition of legal relations in the field of agricultural insurance has been specified. Has been identified problems of the development of the agricultural sector, directly enshrined in the current legislation, hindering the development of agricultural insurance with the state support. The key role of the restoration of lands that have been polluted, clogged, and damage to the fertile layer as a result of hostilities has been proved, and the thesis on the need to improve the current legislation in the field of agricultural insurance has been proved. The article concludes that the draft law number 8025, which provides for amendments to the Law of Ukraine «On the Features of Insurance of Agricultural Products with State Support», is aimed at introducing insurance of agricultural products and objects of their storage (location) or processing against risks due to military and military operations, therefore, should guarantee compensation for possible losses to agricultural producers in the event of destruction or damage to property due to hostilities. It is argued that land plots, which are the main means of production in agriculture and, in fact, the basic asset in agribusiness, should also be objects of agricultural insurance at the level of agricultural products or crops. It is noted that relations in the field of creating an insurance system and guaranteeing commercial and non-commercial risks when conducting export operations with agricultural products are an independent object of legal regulation, given the role of Ukraine as a world exporter of grain and other types of agricultural products. It has been determined that the prospect of further scientific research is the settlement of the procedure for simplifying the mechanism of state support in the field of agricultural insurance and expanding the range of insured events and the object structure of these legal relations. The methodology for studying the legal problems of agricultural insurance under martial law is based on the provisions of the general scientific dialectical method of cognition. To achieve the goal of the study, formal-legal, formal-logical, scientific methods and the method of scientific forecasting were also applied.
General principles of public administration of climate relations in the European Union
Authors: Machuskyi V.V.
Published: February 2023

The article is devoted to the study of theoretical problems, the study of the role of the institution of the European Union, which carries out public administration in the field of environmental protection and climate change prevention.

In the article, the author focuses on the fact that since the middle of the last century in Europe, there has been a significant deterioration of the environment, and the rise in temperature indicates significant problems associated with climate change.

It is noted that public administration in the field of environmental protection and climate change prevention in the European Union by institutions implementing state policy in the specified field. The author investigated the formation of a system of bodies (institutions) of general and special competence in the field of environmental protection and climate change prevention in the EU.

The author focuses on the fact that the formation of legal regulation of environmental and climate relations, as well as public administration in the specified area, was significantly influenced by the holding of the UN Stockholm Conference on environmental problems.

The article examines the role of the European Union institution in the field of environmental protection and climate change prevention. It was concluded that the EU institutions are the main regulators of integration processes that ensure the consistency of the EU policy, especially in the field of environmental protection and climate change prevention.

The article analyzes the system of bodies of special competence of the European Union and their influence on the implementation of EU policy in the field of environmental protection and climate change prevention. Also, in the article, the author emphasizes the areas of activity of non-governmental international organizations that contribute to the improvement of environmental protection and prevention of climate change.

The author researched the experience of organizing public administration in the field of environmental protection and climate change prevention in the Federal Republic of Germany and the Republic of Italy and concluded on the expediency of borrowing the experience of the EU states in Ukraine.
Some issues of normative and legal provision of administrative protection of the sphere of fuel and energy complex
Authors: Demchenko A.Yu.
Published: February 2023

The article is devoted to the study of regulatory and legal provision of administrative protection of the fuel and energy complex. It was determined that the administrative protection of the fuel and energy complex is an organizational and legal activity of public administration bodies, which is carried out to ensure the proper functioning of electric power, nuclear, coal, peat, oil and gas, and oil and gas processing complexes with the help of legally defined legal means.It has been established that the normative legal support is reflected in the set of normative legal acts of different legal force, the provisions of which regulate the sphere of administrative protection of the fuel and energy complex. It is noted that the coverage of the entire array of regulatory and legal acts from the specified direction is complicated due to their voluminous quantitative parameters. The gradation of normative legal acts was carried out depending on the subject of their impact on the substantive characteristics of the administrative protection of the fuel and energy complex by distinguishing: 1) normativelegal acts relating to the order of functioning of social relations related to the fuel and energy complex; 2) normative legal acts, which define the subjects of public administration and their powers to regulate public relations related tо the fuel and energy complex; 3) normative legal acts, which determine the procedure for bringing to administrative responsibility for violationsrelated to the functioning of the fuel and energy complex.The specifics of the functioning of the fuel and energy complex in a special period covering the time of the introduction of martial law were revealed. The list of public administration entities authorized to regulate public relations related to the fuel and energy complex primarily includes the bodies of executive power: the Cabinet of Ministers of Ukraine, the Ministry ofEnergy of Ukraine, the State Energy Supervision Inspectorate of Ukraine, the National Commission for State regulation in the spheres of energy and communal services.
General theoretical features of the internally displaced persons legal status in Ukraine
Authors: Zavalnyi V.V.
Published: February 2023

The article is dedicated to the comprehensive study of the problems of the general theoretical features of the internally displaced persons legal status (IDPs) in Ukraine during the war as the most acute period of socio-legal anomie, when all citizens of the state are negatively affected by military actions.

It was found that the provision of psychological assistance to the IDPs is an important aspect, which allows people who live in difficult conditions to emotionally and psychologically stabilize their state and, as a result, avoid certain illegal actions and not become the object of criminal encroachments by offenders. The IDPs have all the rights of citizens of Ukraine and certain rights provided by their status. The procedure for citizens of their rights realization outside of their permanent residence may be complicated by the IDP's certain documents lack, their loss, or ignorance of their rights as the IDPs.

The problems of children rights compliance who have become internally displaced persons are emphasized. In Ukraine, targeted state support is provided to children registered as internally displaced persons. Along with solving the material and household aspects of life, it is also necessary to prevent manifestations of illegal behavior among children, bullying, etc. The preventive work of juvenile prevention bodies, together with psychological services, should be aimed at integrating the minor into a new environment based on the principles of legality and compliance with the rights of the child.

It is noted that an important aspect is the provision of free legal aid to the IDPs. In the cities that host the main number of IDPs, it is possible to get qualified legal assistance in the premises of railway stations regarding the main issues of the registration procedure, temporary settlement, food, medical and social assistance. Social solidarity and interaction of all citizens is highly important.

The state should show maximum support for the specified category of citizens in order to prevent violation of their rights and freedoms, manifestations of illegal behavior of these persons and towards them, as well as, with the aim of avoiding the mass Ukrainian refugees flow due to the imperfect system of ensuring the basic rights of IDPs by relevant services and authority structures.
Legal aspects of electronic document management in telemedicine
Authors: Yarema O. , Ilyushyk O.M.
Published: February 2023

In the article from the standpoint of the theory of administrative and information law, based on the current legislation and regulatory requirements of the European Union, the theoretical and practical aspects of electronic document flow in telemedicine are considered. The topicality of the topic determined by the need to improve the legislation with the aim of comprehensive theoretical justification of increasing the effectiveness of telemedicine activities in the conditions of digital transformation of Ukraine. In the course of the study, the methodology of a systematic complex analysis of legal phenomena was applied using factorial and evolutionary methods of research. It is indicated that in the countries of the European Union, three main models of health care information systems have been formed, which differ in the ways of storing medical information and management: decentralized, centralized and patient-oriented. It was noted that the main legal issues of the renewal of the medical system of Ukraine and the directions of activity in the conditions of reform include telemedicine, and its component - electronic document flow. The essence and features of electronic document management in telemedicine in the countries of the European Union have been clarified. The electronic health care systems of individual countries of the European Union considered, attention is paid to the experience of use. The state of legal provision of information security in telemedicine with regard to electronic document flow studied, taking into account the experience of the countries of the European Union. The analysis of ensuring information security in the context of personal data in the medical systems of European countries and Ukraine was carried out. The further vector and direction of the development of the national health care system in terms of the Concept of the development of electronic health care, which is important for medical care and rehabilitation of citizens who suffered during the war, was determined. Important aspects and measures to optimize activities in the field of telemedicine highlighted, which need to be paid attention to during further reform and creation of new digital resources for a more comfortable transition and use of the latest digital technologies in the field of health care.
Certain aspects of the use of goal setting as a methodological technique for the study of administrative law
Authors: Kantor N.Yu.
Published: February 2023

The article, based on the analysis of the norms of public and private law, offers some advantages of using goal-setting as a methodological technique for the study of administrative law. It was established that the process of formation and implementation of goals has an important role in administrative and legal regulation, and therefore should have a scientific basis in the form of “goal setting”. If the goals of all elements of the administrative law system are properly defined and formulated, then, firstly, law enforcement subjects will be able to carry out targeted management, control, law enforcementactivities and activities related to the provision of administrative services, and secondly, this will create favorable conditions for the formation and the development of legal awareness among private individuals, which will have a positive effect on the observance of the general regime оf legality in the state. It has been proven that “right in the subjective sense” goes beyondresearch through the lens of goal setting. This is due to the fact that, firstly, natural human rights are only declarations that cannot be realized in real life without “rights in the objective sense”, secondly, the rights of a citizen are the result of legal regulation of social relations in a specific country, and therefore they should be considered exclusively as a result of achieving the goals of administrative and legal regulation. It is proved that the criteria for dividing the law into public and private law are the goals of legal regulation, which can be determined through the analysis of types of legal regulation. It was found thatthe following type of legal regulation is used in administrative and legal regulation in relation to public administration entities: “Only what is provided for by law is allowed.” That is, the main goal of administrative and legal regulation in relation to subjects of public administration is to prevent arbitrariness on the part of subjects endowed with public-authority powers. In relation to private individuals, the following type of administrative and legal regulation is used: “All that is provided for and not prohibited by law is permitted.” This type of administrative-legal regulation pursues two goals at once, which are hierarchically located next to each other: 1) to maximally ensure the realization of the rights and freedoms of a person and a citizen in relationswith the state and other subjects endowed with public-authority relations; 2) not to limit the variability of the behavior of private individuals in administrative legal relations in cases where there are no clear requirements for such behavior in the form of prescriptions or prohibitions or in cases where there are gaps in administrative and legal regulation.
Vocational pre-higher education as an object of public administration
Authors: Liutikov P.S. , Pryimachenko D.V.
Published: February 2023

The article attempts to consider, based on the analysis of doctrinal and normative sources, vocational pre-higher education as an object of public administration. In particular, it is stated that the purpose of vocational pre-higher education has a general and individual (special) character, a broad and narrow understanding. In a narrow sense, vocational pre-higher education is aimed at the formation and development of a certain level of qualification, which will confirm the ability of a person to perform specialized tasks in a certain field of professional activity or in the learning process, which requires the application of the provisions and methods of the relevant sciences and may be characterized by certain uncertainty of conditions; responsibilityfor the results of one’s activity; exercising control over other persons in certain situations. The general goal of vocational pre-higher education is to ensure sustainable social, economic and innovative development of the state due to highquality training of competitive human capital and strengthening the connection between society and vocational higher education.In turn, when outlining the principles of public administration in the field of vocational prehigher education, the authors suggested starting from the relevant principles of state policy in this field, established in a special law. Among the components of the system of professional preliminary pre-higher education, the following are outlined: institutions of professional preliminary pre-higher education; fields of knowledge and specialty; licensing conditions for conducting educational activities; standards of professional preliminary pre-higher education; bodies carrying out management, supervision and control inthe field of professional preliminary pre-higher education; scientific and methodical (educational and methodical) institutions; participants of the educational process.The thesis is formulated that vocational pre-higher education as an object of public administration is a social system consisting of relevant interconnected components that function due to vertical and horizontal connections of an internal and external nature in order to ensure stable social, economic and innovative development of the state due to high-quality training of competitive human capital and strengthening of the connection between society and professional pre-higher education.
Prospects for application in Ukraine of international experience in searching missing persons under special circumstances
Authors: Sydorenko S.G.
Published: February 2023

This article contains a comparative and legal analysis of the organization of search for persons missing under special circumstances, in Ukraine and other countries. The author researches the order of search for missing persons in Ukraine and countries that had military and armed conflicts, as a result of which they introduced special mechanisms for searching for persons missing in such conflicts.

The international experience of some countries on the functioning of domestic bodies with competence to solve issues related to the search for missing persons, including: the Federal Republic of Germany, Bosnia and Herzegovina, the Republic of Croatia, Montenegro, the Republic of Serbia, the Republic of Kosovo, which in different time periods had armed conflicts in their territories.

The article analyzes the interaction of individual countries with the International Commission on Missing Persons, an intergovernmental organization created to solve the problem of persons missing due to conflicts that took place in the Balkan Peninsula. It is noted that this intergovernmental organization carries out its functioning, including on the territory of Ukraine as a result of armed aggression by the Russian Federation.

The author emphasizes that the proper prerequisites for the implementation of state policy in the field of regulation of public relations are created in Ukraine, which are related to the search for persons missing under special circumstances, the certainty of legal status and social protection of such persons. At the same time, the need for the use of positive international experience of other countries in Ukraine on the organization and application of a set of measures during the search for persons missing under special circumstances has been highlighted.

It is noted that the necessary consequence of the search for missing persons is the restoration of the social status of such persons, their constitutional rights, obligations, and freedoms that are guaranteed by the state.

It has been established that Ukrainian legislation currently defines a wide range of state authorities that are authorized to search for persons missing under special circumstances. At the same time, the author's position on the advantages and disadvantages of such a subject composition of search activity is given.
International treaties as sources of criminal law policy
Authors: Ostrohliad O.V.
Published: February 2023

The article is devoted to considering the multifaceted approaches to the concept of the source base of criminal law policy, as well as its components, in particular, international treaties. The characteristics of the main approach to understanding the sources of criminal law policy are disclosed, in which the types of sources that are collectively the sources of criminal law policy are listed. It is indicated that the following stand out: the Constitution of Ukraine; Laws of Ukraine (primarily, the Criminal Code of Ukraine and other laws); subordinate legal acts, if they determine the conceptual approaches of the criminal law policy, or specific measures for its implementation; judicial precedent (Decisions of the ECHR regarding Ukraine, as well as decisions that contain the established legal position of the ECHR; Decisions of the Constitutional Court of Ukraine; Resolutions of the Plenum of the Supreme Court of Ukraine when they determine the general principles, directions and limits of application of substantive criminal law and when determining specific directions and limits of application criminal law, which defines responsibility for specific types of criminal acts; legal positions of the Supreme Court); International treaties ratified by Ukraine, which in one way or another affect the national criminal legislation. When characterizing international treaties as sources of criminal law policy, attention is focused on the fact that they can be conditionally divided into three groups: - those that define conceptual approaches to combating crime in general; - those that determine the grounds and limits of criminal liability for the commission of relevant types of crimes and require the issuance of national normative legal acts for their implementation; - those that determine the grounds and limits of criminal liability for the commission of relevant types of crimes and act directly.
The role of civil society institutions in combating the consequences of russian aggression against Ukraine
Authors: Iatsyna M.O.
Published: February 2023

The article discusses the role of civil society institutions in the process of overcoming the consequences of russian aggression against Ukraine. It is highlined that one of these consequences is the need to document numerous war crimes in order to further use such materials in international courts and tribunals. It is emphasized that in the context of martial law, the law enforcement system faces a number of objective factors that impede the adequate performance of their functions, including such as 1) the need to document and investigate mass acts of commission of war crimes while continuing to perform the functions of law ordering; 2) loss of access to temporarily occupied territories when they became the epicentre of mass crimes on the part of the invaders. It is seen that civil society and its numerous institutions, which were actively involved in the process of overcoming the consequences of aggression, became an obvious support for the state and the law enforcement system. The activity and degree of involvement of civil society and its institutions in activities related to overcoming the consequences of the russian federation full-scale war aggression against Ukraine demonstrate a high level of involvement of all kinds of civic institutions in this process, which is carried out in different directions (from the assistance of the army – to evacuation of civilians from the territories affected by war actions, etc.). One of the tasks assumed by civil society was the activity of documenting war crimes, which was actively involved in civil society institutions, both Ukrainian and international representatives. It is emphasized that the important role of social institutions in the process of documenting war crimes is emphasized by Nobel Prize Committee, which honoured the Peace Award 2022 for civil society representatives, in particular for their activities in the documentation of war crimes. As a result, the need to develop legislative mechanisms on the interaction of the state and its law enforcement system with civil society institutions in the direction of documenting war crimes is emphasized.
Problems of gender equality in sports: topical issues of combating discrimination
Authors: Balynska O.M.
Published: February 2023

The article analyzes gender problems of discrimination in the field of sports activities. It was established that discrimination is anegative social phenomenon and manifests itself in all spheres, including sports. Despite a number of regulatory and institutional legal guarantees, athletes are exposed to negative situations, including oppression, intolerance, unequal treatment, and even violence. The goal of the modern ideology of legal regulation in the field of sports is to ensure somatic andpsychological well-being in all spheres of personal development of athletes, including the eradication of manifestations of discrimination, which is especially widespread on the basis of gender.Stereotyped thinking permeates sports activities, where certain sports are identified with a separate gender, resulting in genderdiscrimination against both women due to their supposedly strengthened masculine identity and men for choosing fragile sports.It is noted that the problems of stigmatization in sports have an ancient nature, but do not change in the context of the transformation of the phenomenon itself. Currently, the issue of eSports and its recognition at the professional level isbeing actively discussed. However, according to experts, the problem of gender discrimination in this area is particularly significant.Addressing systemic issues, including discrimination, requires good and open sports governance to create a culture that is trulyfair, accessible, inclusive and supportive. It has been established that increasing the numerical representation of women is an important feminist project in various institutional settings and promotes gender equality. However, the number in itself does not mean ensuring the principle of non-discrimination. The problems that have not been solved at the moment are forms of lower wages, lack of real equality in the occupation of managerial positions and coaching staff, uneven popularization in the mass media.
Legal regulation of sports in Ukraine: globalization challenges
Authors: Zharovska I.M.
Published: February 2023

The article is devoted to the analysis of globalization challenges in the field of legal regulation of sports in Ukr aine.Legal regulation in the field of sports has a complex nature and concerns many complex aspects, is modified and improved in accordance with the information environment and global сhallenges of today. It was established that sport is a uniquephenomenon that requires two-level legal regulation: national and global. International sports law can be applied by national bodies, federations and courts. The legal regulation of national and international sports competitions has become extremely complex and has entered a new era that creates a fertile ground for the creation and development of a broader legaljurisprudence with potentially wide impact and application. Evolving sports law has a significant impact on the development of international and domestic law, forms a body of substantive legal doctrine ripe for analysis from a comparative lawperspective, and has important implications for global dispute resolution.Physical activity and sport have been proven to be essential for improving health and well-being in order to achieve the Sustainable Development Goals.Three key aspects of global challenges in the field of legal regulation of sports are singled out: the transformation of the legal understanding of sports law, which occurs in connection with the emergence of new types of sports activities, whichmust be regulated; the rapid commercialization of sports threatens to hinder the primary purpose of sports activities, so the sports sector develops rules that try to maintain a competitive balance between participants; the formation of human somatic rights into a complex field, which leads to a change in ideology, where the human body is an axiological property and external factors, including the legal policy of the state, must treat bodily rights with dignity.
Association between the empirical dietary inflammatory index and musculoskeletal pain in community-dwelling older adults: a cross-sectional study
Authors: Rezaei Mahshid , Tajary Zahra , Esmaeily Zahra , Eyvazkhani Atefeh , Daei Shahrzad , Dara Marjan Mansouri , Rezaei Mohaddeseh , Djazayeri Abolghassem , Motlagh Ahmadreza Dorosty
Published: February 2023

Objectives: Inflammation has been proposed to be one of the main causes of musculoskeletal pain. Diet is a lifestyle factor that plays an important role in managing inflammation; thus, we assessed the inflammatory potential of diets using the empirical dietary inflammatory index (EDII) to investigate the relationship between diet and musculoskeletal pain.Methods: This cross-sectional study included 212 elderly individuals who were selected from health centers in Tehran, Iran. Dietary intake was evaluated using a valid and reliable 147-item food frequency questionnaire. To measure the intensity of pain, a visual analogue scale was used. Multiple linear regression was applied to assess the association between the EDII and musculoskeletal pain.Results: In total, 62.7% and 37.3% of participants had mild and severe pain, respectively. The EDII values were 0.97±0.72 and 1.10±0.66, respectively, in those with mild and severe pain. A higher EDII score was associated with more intense musculoskeletal pain after adjusting for age and sex (β=0.20; 95% confidence interval [CI], 0.06–0.26; p<0.001), but not after adjustment for other confounders (β=–0.13; 95% CI, –1.54 to 0.60; p=0.39).Conclusion: Our findings indicated that higher dietary inflammation might not be associated with musculoskeletal pain in older adults. However, further investigations are required to confirm these findings.
Relationship between Body Anthropometric Measurement and Parathyroid Hormone in Female Subjects
Authors: Maherdika Mabruratussania , Hendrianingtyas Meita
Published: February 2023

The distribution of fat tissue is related to the risk of metabolic diseases. Parathyroid Hormone (PTH) is an essential hormone for calcium homeostasis. According to several types of research, body fat affects PTH levels. Currently, Body Mass Index (BMI) is not the only parameter needed to identify the body fat distribution in accordance with chronic disease risks such as Waist Circumference (WC), Waist to Hip Ratio (WHR), and Waist to Height Ratio (WHtR). The study aimed to determine the relationship between body anthropometric measurement and PTH. A cross-sectional study was performed on a healthy population of 75 healthy female volunteers with a BMI â‰¥ 23 kg/m2. Waist circumference, WHR, WHtR, and BMI measurements were carried out and followed by the PTH fragment 1-84 (PTH1-84) test. Data were analyzed using the Spearman test with a significance of p<005. There was no significant correlation between PTH and WHR (r=0.057; p=0.628). There was weak correlation between PTH and BMI (r=0.268; p=0.020), WC (r=0.287; p=0.012) and WHtR (r=0.238; p=0.04). Body mass index, WC, and WHtR can be used as anthropometric parameters to determine PTH disorders
Campylobacteriosis in An Outbreak of Foodborne Disease at Bantar Gadung Village Palabuhan Ratu
Authors: Budiailmiawan Luhung , Parwati Ida , Rita Coriejati , Lokida Dewi
Published: February 2023

Campylobacteriosis is a rare enteritis case in Indonesia. On September 12, 2019, there was an outbreak of foodborne diseases with the symptoms of fever, abdominal cramps, and bloody diarrhea after eating food from the Tahlilan (funeral prayer) ceremonial at Bantar Gadung village Palabuhan Ratu Sukabumi. The laboratory and epidemiological investigationwere performed. Fresh stool samples were collected from 18 suspected cases. Gram stain, routine stool examination, and PCR were performed. The PCR method was used based on the nested PCR method by Platts-Mills et al. for Campylobacter spp. The positive result was identified by visualization in gel electrophoresis at 816-bp. Interview, environmental investigation, and analysis of incidence rate were performed for epidemiological study. The majority of patients were males aged 33-48 years old. The main symptoms were fever (100%), abdominal cramps (100%), and bloody diarrhea (11/18;61%). Nine of them (9/11; 82%) were confirmed by Gram staining as Gram- negative bacteria, with comma, s-shaped, or seagull appearance, as presumptive Campylobacter spp. Two patients (2/18;11%) were confirmed infected with Campylobacterspp. by PCR and sequencing tests. It has been found that this outbreak was caused by food contaminated with Campylobacter spp. The incidence rate of Campylobacteriosis in this outbreak was 11%.
Relationship between High Sensitivity C-Reactive Protein and Total Testosterone Levels in Male Patients with Stage V Chronic Kidney Disease
Authors: Puspitasari Metana , Pramudianti MI. Diah , Hadisuparto Yuwono
Published: February 2023

The incidence of decreased total testosterone level increases in stage V CKD patients. Decreased total testosterone levels is influenced by uremia and hemodialysis bioincompatibility through an increase in the inflammatory mediator hs-CRP. Obesity and age are risk factors of CKD incidence which can directly affect testosterone level. This study aimed to analyze the relationship between hs-CRP, serum urea, age, obesity, and hemodialysis duration with decreased total testosterone levels in stage V CKD patients. This observational study with cross-sectional approach was performed are 60 stage V CKD patients treated in Dr. Moewardi General Hospital, Surakarta on November 2020. The data were analyzed with 2x2 table test, followed by multivariate analysis using logistic regression. The examinations of total testosterone and hsRP used ECLIA and immunoturbidimetric assay, respectively. This study obtained 21 (37%) study who experienced a decreased total testosterone level (<3ng/mL). hs-CRP level [PR 3.656 (95% CI: 1.202-11,124; p=0.020)]; obesity [PR 4.156 (95% CI: 1.272-13.581; p=0.015)] and urea [PR 4.474 (95% CI: 1.273-15.728; p=0.015)] significantly associated with decreased total testosterone level of <3 ng/ml. Meanwhile age was not statistically significant (p=0.694) and hemodialysis duration obtained PR <1 and CI 95% < 1 (p=0.018). Therefore in patients with stage V, hs-CRP levels â‰¥ 0.65 mg/dl, serum urea â‰¥ 120 mg/dL, and obesity correlate with decreased total testosterone level while age is not associated with decreased total testosterone level. The hemodialysis duration is not a risk factor of decreased total testosterone.
The Differences of N–Acetyl–Î²–Glucosaminidase and Î²2 Microglobulin levels in Patients with and without Early Diabetic Nephropathy
Authors: Citra Cynthia , Limijadi Edward Kurnia Setiawan , Rachmawati Banundari
Published: February 2023

Diabetic Nephropathy (DN) is becoming the most serious microvascular complication, which be marked by the presence of persistent albuminuria. N–asetil–Î²–glucosaminidase is dominant lyzosom enzyme in the renal tubule epitel. Î²2 microglobulin is low molecular weight protein which produced by major histocompatibility complex class 1 (MHC-1) expressed cell in all nucleated cell. N–asetil–Î²–glucosaminidase and Î²2 microglobulin could be new usefull marker for early DN. Analytic observational study with cross sectional approach was conducted in May – July 2019 involving 27 non diabetic patients (K1), 27 diabetic patients without DN (K2) and 27 diabetic patients with early DN (K3) at the Clinical Pathology department of Faculty of Medicine, Diponegoro University and Diabetic Clinic. Data include age, gender, fasting blood glucose, blood preasure and urine albumin creatinine ratio. N–asetil–Î²–glucosaminidase level between groups were analyzed using Anova, Î²2 microglobulin level between groups using Kruskal Wallis, p<0.05 were considered significant. There are significant differences in levels of N–asetil–Î²–glucosaminidase between K1 and K2 (p =0.01), K1 and K3 (p =< 0.01), K2 and K3 (p = 0.03) and Î²2 microglobulin  between K1 and K2 (p = 0.02), K1 and K3 (p =< 0.01), K2 and K3 (p< 0.01). N-acetyl-Î²-glucosaminidase and Î²2 microglobulin levels were higher in K2 compared to K1 and increased higher in K3 compared to K1 and K2. N-acetyl-Î²-glucosaminidase and Î²2 microglobulin can be used as an alternative marker for early DN.
The Predictive Value of Glucagon-Like Peptide 1 Plasma Levels on Acute Heart Failure
Authors: Wahyudi Muhamad Firman , Suparyatmo JB. , Ariningrum Dian
Published: February 2023

Acute Heart Failure (AHF) is one of the mechanical complications of Acute Myocardial Infarct (AMI). The diagnostic approach of AHF caused by AMI is based on clinical score, imaging, use of invasive instruments, and laboratory parameters. Glucagon-Like Peptide-I (GLP-1) is an incretin hormone derivate of proglucagon gene transcription, secreted by the L cells from the mucosa of the ileum, colon, and rectum. The cardioprotective effect of GLP-1 through the dependent and independent pathway produces a direct and indirect cardiovascular effect that increases the functional capacity in AHF patients. This study aims to find the predictive value of plasma GLP-1 towards the incidence of AHF in patients with AMI. This study was conducted on 35 patients diagnosed with AMI at Dr. Moewardi General Hospital Surakarta, in October-December 2020. Glucagon-like peptide-I was measured using the ELISA sandwich. The cut-off of plasma GLP-1 was determined using the Receiver Operating Characteristic (ROC) curve. Statistical analysis showed an RR (95% CI) of 2.292 (0.587–8.943) with a p=0.229 for age, 1,143 (0.299–4.367) with a p – 0.127 for a history of type 2 diabetes (T2DM) and plasma GLP-1 concentrations below Cut-Off Value (COV), which was 2.881 (0.729–11.381) with p=0.127. Age, a history of T2DM, and plasma GLP-1 below COV did not significantly affect AHF complications in patients with AMI.
A child with Down Syndrome and Type 2 Diabetic Mellitus
Authors: Pardosi Betti Bettavia Hartama , Herawati Sianny , Mulyantari Ni Kadek
Published: February 2023

Down Syndrome (DS) is one of the common chromosomal disorders that raise mental retardation. It is known that DS patients have an autoimmune disorder affecting the endocrine and non-endocrine organs. It is a rare occurrence of type 2 Diabetes Mellitus (type 2 DM) disease in children with DS. Type 2 DM occurs due to impaired insulin secretion and excessive hepatic glucose production, unlike type 1 DM, caused by the destruction of íŸ-cells in autoimmune Langerhans. A 10-year-old girl patient was referred from Tabanan Hospital to Sanglah Hospital, Denpasar. Patients were admitted to the hospital with decreased consciousness, treated for four days, and observed in ICU for 2 days. Vomiting twice, no seizures, urinating normally. No significant past medical history was found. Physical examinations showed a typical Mongolian face, short neck, expanded occipital area, small eyes, and a mouth with a prominent tongue. Laboratory data revealed fasting blood glucose of 473 mg/dL and an HbA1C level of 12.6%. Urinalysis showed ketone 3+. The C-peptide test showed a reasonably good íŸ pancreas cell function. Down syndrome is associated with autoimmune diseases, including type 1 diabetes. The exact number of down syndrome cases with type 2 DM remains unknown; however, it was known that the case is infrequent.
Correlation between Slope 2 in Clot Waveform Analysis of Activated Partial Thromboplastin Time with Factor VIII Activity in Hemophilia A
Authors: Yolanda Raissa , Prihatni Delita , Rita Coriejati , Turbawaty Dewi Kartika
Published: February 2023

Hemophilia A is an inherited factor VIII deficiency disease, related to X chromosome. Diagnosis of Hemophilia A is made based on Factor VIII assay. Nowadays, Hemophilia A therapy is by giving factor VIII concentrate, so that monitoring of this therapy must be done by examine Factor VIII activity, but examination of Factor VIII activity is currently still limited in facilities and quite expensive. One of activated partial thromboplastin time (aPTT) optical methods can provide information about every stage of coagulation through clot waveform analysis. Factor VIII activity can describe in slope 2 of clot waveform analysis, which deficiency of factor VIII will cause slope 2 slighter than normal, because the clot form is not optimal and the light transmission recorded at clot waves do not decrease maximally. The aim of this study was to analyze the correlation between slope 2 on the clot waveform analysis of the optical method on aPTT test with Factor VIII activity in hemophilia A subjects. This was a correlative observational study cross sectional study, conducted at Hasan Sadikin General Hospital Bandung in August 2018-September 2019. The subjects were member of Hemophilia A sufferers of West Java Hemophilia Society. The research subjects were assesed for Factor VIII activity and optical method of aPTT. Slope 2 calculated from the clot waveform analysis that formed in aPTT examination. This study involved 43 subjects, with a median age of 6 years, an age range of 1-45 years, and 51.2% of patients aged 6-17 years. The results of Factor VIII activity in this study had a median 0% with a range 0-25.9%, and the value of slope 2 had a median 1.0%T/sec with a range 0.5-3.5%T/sec. The correlation test between slope 2 and Factor VIII activity with 95% confidence interval using Spearman's correlation test showed very strong positive correlation which statistically significant (r = 0.854 and p <0.001). Conclusion: there was a statistically significant very strong positive correlation between slope 2 on the clot waveform analysis of aPTT optical method test with the activity of Factor VIII in Hemophilia A.
Correlation between Immature Platetet Fraction Value and SOFA Score in Sepsis Patient
Authors: Ashan Hesty Rhauda , Husni Husni , Alia Eugeny
Published: February 2023

Sepsis is a medical emergency that describes systemic inflammation reaction to infectious process that can lead to organ dysfunction and death. Sequential Organ Failure Assesment (SOFA) score is used to assess severity of organ dysfunction in septic patients. Immature platelet fraction (IPF) value can be used to evaluate thrombopoiesis. Research shows IPF can provide information regarding inflammatory activity and disease prognosis. A high IPF value in septic patient indicates the formation and recruitment of immature platelets that are triggered by infection. The aim of this study was to determine correlation between IPF value and SOFA score in sepsis patients. This was an analytical study with a cross-sectional design in 28 patients with sepsis who met the inclusion and exclusion criteria and conducted IPF tests at Central Laboratory of Dr M. Djamil Padang Hospital. The study was conducted from February 2020 to March 2021. Value of IPF was performed using automated hematology analyzer with flow cytometry method and SOFA scores are assessed by clinicians and obtained from medical records. Data were analyzed by Pearson correlation test, significant if p <0.05. Median value of IPF in patients with sepsis was 4.8 (1.4-15.7) %. Median of SOFA score in patients with sepsis was 5,5 (2-12). Correlation test showed a strong positive correlation between IPF values and SOFA score with r= 0.684 and p <0.05. There was a strong positive correlation between IPF values and SOFA score in sepsis.