bluuebunny/crossref_metadata_2025 huggingface dataset:
Time for change: the need for a pragmatic approach to addressing organ shortage in the UK
Authors: Farrell Anne-Maree
Published: August 2008

This article sets out the key findings from the seminar series ‘Transplantation and organ deficit in the UK: Pragmatic solutions to ethical controversy’ which ran from November 2006 to March 2008, and was sponsored by the Economic and Social Research Council. A broad range of issues were examined in the seminars, including religious and cultural attitudes affecting organ donation, the role of health-care professionals and what could be learned from the experiences of other countries, particularly in the European context. Core participants in the series came from a range of academic and practitioner backgrounds and had different ethical perspectives on issues affecting organ donation and transplantation. Notwithstanding such diversity, the findings set out in the article reflect the fact that core participants were focused on developing a principled, yet pragmatic approach to dealing with the urgent problem of organ shortage in the UK.
Independent clinical predictors of impaired response to hepatitis B vaccination in HIV-infected persons
Authors: Kim H Nina , Harrington Robert D , Van Rompaey Stephen E , Kitahata Mari M
Published: August 2008

Summary:

Protective response rates to hepatitis B (HB) vaccination have been reported as low as 18-62% in HIV-infected persons. The relative importance of various predictors for this poor response has not been fully characterized. In this retrospective cohort study, we examined the relationship between clinical characteristics and vaccine non-response (HB surface antibody <10 IU/L) among patients attending an urban HIV clinic. Among the 97 patients who met the inclusion criteria, 43 (44%) developed a protective antibody response. In multivariate analyses, age >40 years (odds ratio [OR] 3.03 [95% confidence interval [CI], 1.14-8.06]; P = 0.026) and alcohol abuse (OR 4.92 [95% CI, 1.72-20.89]; P = 0.007) were independent predictors of failure to develop vaccine response. In addition, CD4 nadir <200 (OR 7.24 [95% CI, 1.91-27.41]; P = 0.004), rather than CD4 current to vaccination, remained a strong independent risk factor. Patients with HIV viral suppression on highly active antiretroviral therapy had a significantly lower rate of vaccine failure (OR 0.31 [95% CI, 0.11-0.91]; P = 0.033), after adjusting for these other covariates. Our findings underscore the importance of confirming seroconversion after HB vaccination in HIV-infected patients and initiating vaccination early in the course of HIV infection.
Human papillomavirus detection and typification in cutaneous and mucosal lesions of HIV-seropositive patients
Authors: De Gusmão Nunes Mariana , Azevedo-E-Silva Melissa , Gonçalves Carolina Pereira , Trope Beatriz Moritz , Oliveira Ledy Do Horto Dos Santos , Ramos-E-Silva Marcia
Published: August 2008

Summary:

High-risk human papillomavirus (HPV) in a lesion is related to an increased chance of neoplasic transformation, especially when with immunosuppression, as in HIV infection. We investigated HPV frequency in cutaneous and mucosal lesions of HIV-seropositive male patients. The frequency of malignancy, its association with the HPV type detected and some clinical variables were also assessed. A total of 38 lesions from 27 patients were studied in a period of 18 months. The biopsied fragment was submitted to HPV detection and typification, through polymerase chain reaction with generic (MY09/11) and specific (types 6, 11, 16 and 18) primers. HPV frequency was 63.2%, with detection of HPV types 6, 11 or 16 in 18 lesions and with multi-infection in three. There was low detection of high-risk HPV (type 16, 18.4%) and no HPV type 18. Of the lesions, 36.8% were already premalignant or malignant, and the frequency of moderate or severe dysplasia was higher in the study patients than that described in the HIV-seronegative population. High-risk HPV (type 16) was detected in four benign lesions and low-risk HPV (type 6) in three premalignant genital lesions. There was no significant association between the clinical variables and an increase in the prevalence of premalignant or malignant lesions.
Management of under-16-year olds in UK genitourinary medicine clinics: British Co-operative Clinical Group
Authors: Mcandrew S E , Williams O E , Rogstad K E , Kell P D
Published: August 2008

Summary:

In 2004, the management of under-16-year olds in UK genitourinary (GU) medicine clinics was surveyed. Questionnaires were sent to 185 lead GU medicine consultants. A total of 111 questionnaires were returned (60%). Ninety-eight percent of respondents managed young people aged 13-16. Fifty percent managed under 13-year-olds. Twenty-nine percent of respondents ran dedicated young people's clinics. Ninety-eight percent were aware of the National Guidelines, and 74%had adopted them. Fifty-seven percent had a named departmental child protection lead. Thirty-seven percent of consultants had received training specific to child protection issues in GU medicine. Improvements had been made since a similar survey published in 2001, but the need for further training was still apparent.
Prevalence and predictors of herpes simplex virus type 2 infection among female sex workers in Yunnan Province, China
Authors: Wang Haibo , Wang Ning , Chen Ray Y , Sharp Gerald B , Ma Yanling , Wang Guixiang , Ding Guowei , Wu Zhenglai
Published: August 2008

Summary:

The objective of this study was to determine the seroprevalence of herpes simplex virus type 2 (HSV-2), and to evaluate the relationship between HSV-2 infection and sociodemographic factors and the sexual practices of female sex workers (FSWs) in Kaiyuan city, Yunnan Province, China. This cross-sectional study involved 737 FSWs and was carried out from March to May 2006 with confidential interviews and laboratory tests for HSV-2 and other sexually transmitted infections (STI). HSV-2 was the most common STI (68%), followed by Chlamydia trachomatis (26%), Trichomonas vaginalis (11%), Neisseria gonorrhoeae (8%) and syphilis (7%). Prevalence of HIV-1 was 10.3%. Adjusted odds ratios of HSV-2 seroprevalence were 2.6 (95% CI [confidence interval]: 1.30-5.38) for HIV-1 infection, 2.0 (95% CI: 1.33-3.16) for vaginal douching, 2.0 (95% CI: 0.45-0.86) for condom breaking or falling off during sexual intercourse with the client in the previous week, 1.8 (95% CI: 1.07-3.18) for ≥5 years of commercial sex work, 1.6 (95% CI: 1.08-2.33) for ≥5 clients in the previous week, 0.6 (95% CI: 0.45-0.86) for ≥9 years of education. This study identifies a very high prevalence of HSV-2 infections among FSWs in Yunnan Province, with only a few who reported a prior history of genital herpes. HSV-2 serological screening and suppressive therapy should be considered for study populations. Education on the importance of diagnosis, treatment and prevention may help control the spread of HSV-2 infection.
Prevalence and predictors of high-risk human papillomavirus infection in a population-based sample of women in rural Uganda
Authors: Asiimwe Stephen , Whalen Christopher C , Tisch Daniel J , Tumwesigye Elioda , Sethi Ajay K
Published: August 2008

Summary:

High-risk genital human papillomavirus (HPV) infection is aetiologically linked to cervical cancer; however, data on the prevalence and determinants of high-risk HPV infection in Uganda are limited. We conducted a population-based cross-sectional survey among 18-49-year-old women in rural Southwest Uganda. The primary outcome was presence or absence of high-risk HPV DNA (for genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68) in the genital secretions as determined by HPV DNA Hybrid Capture 2 assay (Digene Corp, Beltsville, MD, USA). In 314 women who participated, the prevalence of high-risk HPV was 17.2% (54/314; 95% confidence interval [CI]: 13-21). Older women had a lower proportion of high-risk HPV infection; with a 9% decrease in the odds ratio (OR) of high-risk HPV infection per year increase in age (OR = 0.91; 95% CI: 0.86, 0.96). The odds of detecting high-risk HPV infection was higher among women who were previously tested positive for HIV (OR = 12.1; 95% CI: 2.8, 52.3). In this population of rural Ugandan women, the prevalence of high-risk cervical HPV infection was high. Information on predictors of high-risk HPV infection and intention to receive a vaccine can guide future immunization initiatives for young sexually active women.
Measuring the gap: from Home Office to the National Health Service in the provision of a one-stop shop sexual health service in a female prison in the UK
Authors: Mahto Mrinalini , Zia Shagufta
Published: August 2008

The Genitourinary (GU) Medicine Service was transferred from the Home Office to the NHS from April 2006 at this female prison to give prisoners access to the same quality of health care as the general public. Medline search showed no published data on the prevalence of sexually transmitted infections (STIs) among female prisoners in the UK. The main aim was to develop a one stop sexual health shop and to determine the prevalence and risk factors for STIs, to determine the uptake rate for HIV testing, hepatitis B vaccination and cervical cytology along with requests for usage of contraceptive services. Challenges were met when introducing change to bring the services in line with the local GU medicine clinic. Review of the service at one year along with retrospective case note review from May 2006 to August 2007 was done. Of the 545 new patients seen, history of substance abuse, IVDU, sexual abuse, sex worker and past history of hepatitis C virus and chlamydia were 86%, 41%,12%, 6%, 17% and 24% respectively. The uptake rate for both STI screen and blood-borne viruses (BBVs) testing was high at 87% and 69.3% respectively. STI was diagnosed in 19.6%. Prevalence rates were: Trichomonas vaginalis (TV) 8.2%, chlamydia 5.3%, gonorrhoea 0.2%, genital warts 5.3%, HIV 0.8%, hepatitis C virus 12% and hepatitis B virus 11%. The uptake rate for 1st dose hepatitis B vaccination and cervical cytology were 70% and 92% respectively, 36 accessed contraceptive services.

Provision of one stop shop in a female prison is feasible and practical. STIs, particularly TV, and BBVs prevalence is high among the female inmates. Prevention methods targeting this population needs to be intensified.
Travel medicine and HIV infection
Authors: Igreja Ricardo
Published: August 2008

Summary:

The number of HIV-infected persons who travel is increasing. This increase arises from those who have benefited from advances in antiretroviral therapy. The key to successful travel is careful pre-trip planning although many patients do not obtain advice before travelling. Travel advice for HIV patients is becoming increasingly specialized, and includes travel vaccination and highly active antiretroviral therapy-related issues. A closer collaboration between HIV and travel health clinics could provide better care for HIV-infected individuals.
Fatal outcome of nevirapine-associated toxic epidermal necrolysis
Authors: Leng K , Lonsdorf A , Hartmann M
Published: August 2008

Summary:

The irregular use of antiretroviral therapy (ART) can result in ART-resistance but can also lead to a sensitization between agents with a cross-sensitivity. We report a case of nevirapine-associated toxic epidermal necrolysis resulting in death in an HIV-infected man.
Unilateral penile swelling: an unusual presentation of primary syphilis?
Authors: Cheng S , French P
Published: August 2008

Summary:

Primary syphilis is characterized by a solitary, painless, indurated ulcer (chancre) at the site of inoculation, with associated inguinal lymph nodes that are enlarged, rubbery, painless and discrete. We report a case of syphilis that presented with penile swelling associated with tender lymphadenopathy and review the literature concerning this unusual presentation of early syphilis.
Qualitative and quantitative aspects of the serological diagnosis of early syphilis
Authors: Mcmillan A , Young H
Published: August 2008

Summary:

The aim of the present study was to evaluate the use of various serological tests in the diagnosis of early syphilis. The Murex enzyme immunoassay (EIA) test was used for screening; the Venereal Diseases Research Laboratory (VDRL) test, the Treponema pallidum particle agglutination assay (TPPA) and the Mercia antitreponemal IgM EIA were used in all the patients with a positive screening test and in those with suspected syphilis or in known contacts. In 89 cases of primary syphilis, the Murex EIA screening test was positive in 67 (75%) patients, the Mercia IgM EIA in 80 (90%) cases, the VDRL in 60 (67%) cases and the TPPA in 85 (96%) cases. All the tests were positive in 68 patients with secondary syphilis. In 72 cases of early latent syphilis, the Murex EIA screening test was positive in 68 (94%) patients, the Mercia IgM EIA in 50 (69%) cases, the VDRL in 61 (85%) cases and the TPPA in 68 (94%) cases. The Mercia IgM EIA was the only test positive in four (6%) of these cases; these four patients were known contacts. Antibody titres in the VDRL and TPPA increased as the infection progressed.
Condom ‘turn offs’ among adults: an exploratory study
Authors: Crosby Richard , Milhausen Robin , Yarber William L , Sanders Stephanie A , Graham Cynthia A
Published: August 2008

Summary:

An exploratory study compared the prevalence of multiple types of condom-associated ‘turn offs’ in men and women. Nearly 2000 people completed a web-based questionnaire. Data were analysed from 464 men and women who reported that condoms had turned them off the last time they were used. Gender differences were not observed for the majority (9) of 15 turn offs. The most common turn offs related to loss of pleasure. For example, more than three-quarters of the men and nearly 40% of the women reported decreased sexual sensation (P = 0.0001). Putting on condoms was reported by 43.2% of the men versus 30.2% of the women (P = 0.02). Smell was a relatively frequent turn off, with about one-third indicating this issue and no significant gender difference (P = 0.32). Turn offs pertaining to arousal and orgasm were also common. Findings suggest that numerous physical and psychological condom turn offs may be experienced by men and women while using male condoms. Although some turn offs differed as a function of gender, there was remarkable similarity between men and women.
Pharmacokinetics and Pharmacodynamics of Intranasal Versus Intravenous Fentanyl in Patients with Pain after Oral Surgery
Authors: Foster David , Upton Richard , Christrup Lona , Popper Lars
Published: August 2008

Background:

Fentanyl, a short-acting synthetic opioid, has a pharmacokinetic profile suited to fast relief of brief episodic pain.

Objective:

To characterize the pharmacokinetic-pharmacodynamic correlation of intranasal and intravenous fentanyl in opioid-naïve patients undergoing third molar extraction.

Methods:

A double-blind, double-dummy, crossover design study was conducted, with patients randomized to receive 1 of 4 fentanyl doses (75,100, 150, or 200 μg) by both the intravenous and intranasal routes. Venous fentanyl concentrations were determined for up to 180 minutes and pain scores were recorded up to 240 minutes postdose. Duration of effect and time to rescue medication were also recorded.

Results:

The pharmacokinetics of intravenous fentanyl reflected a 2-compartment model with a clearance of approximately 1.5 L/min. There was moderate (<50%) between-subject variability (BSV; %CV [coefficient of variation]) in the systemic kinetics of fentanyl. Bioavailability of intranasal fentanyl was 89%, following first-order absorption, with a lag of approximately 5 minutes and a half-life of approximately 6.5 minutes. Interpatient absorption variability was approximately 30% BSV for all absorption parameters. Intranasal versus intravenous administration led to a delayed mean fentanyl time to maximum concentration (13 vs 6 min) and lower maximum concentration (1.2 vs 2.0 ng/mL). Analgesic effect lagged behind the venous fentanyl concentration, with a half-life of approximately 2.5 minutes as described by a fractional sigmoid maximum drug effect dynamic model. The concentration-analgesia relationship was steep, with a 50% effective concentration of 0.46 ng/mL (Hill coefficient 3.5). Intranasal onset and offset of analgesia were slightly delayed, principally due to the delay and lag in systemic absorption, with slightly lower peak analgesic effect, compared with intravenous fentanyl. Duration of effect was directly related to intranasal fentanyl dose, with pain scores returning to predose values at approximately 120 minutes (75μg) to approximately 240 minutes (200 μg) after a single dose.

Conclusions:

Intranasal fentanyl showed kinetic and dynamic properties that are desirable for the management of acute, episodic (breakthrough) pain.
Cervical, Mandibular, and Parotid Lymph Nodes of Dogs Naturally Infected with Leishmania infantum: A Histopathologic and Immunohistochemistry Study and Its Correlation with Facial Skin Lesions
Authors: Costa M. M. S. , Lima W. G. , Figueiredo M. M. , Michalick M. S. M. , Tafuri W. L. , Tafuri W. L.
Published: August 2008

The parasite load in cervical, mandibular, and parotid lymph nodes and in the skin of the nose and the pinna from dogs infected with Leishmania infantum were investigated by histologic and immunohistochemical studies. Twenty-two infected dogs with and without signs of infection were examined to demonstrate correlation of signs with parasite load and the correlation of facial skin lesions with parasites in regional lymph nodes. Chronic inflammation of the skin was demonstrated in infected dogs that had no gross skin lesions, confirming that normal-appearing skin can harbor the parasite, likely playing a role in transmission. Dogs with facial skin lesions showed a higher parasite load in parotid lymph nodes than dogs without lesions of the facial skin, based on Leishman-Donovan unit analysis. Based on immunohistochemical analysis, parasite load in parotid and cervical nodes was correlated with that of skin of the nose and pinna, as was the parasite load in mandibular lymph nodes and skin of the external nose. We demonstrated a logical involvement of the lymphatic vessels and their specific anatomic draining sites.
Arterial Calcification in Race Horses
Authors: Arroyo L. G. , Hayes M. A. , DeLay J. , Rao C. , Duncan B. , Viel L.
Published: August 2008

Calcification of large arteries has been sporadically reported in horses. The pathogenesis is still unknown, but recent studies in humans suggest that this is a regulated biomineralizing process. This study surveyed the prevalence, distribution, and severity of vascular calcification in Thoroughbred and Standardbred racehorses. Histopathologic, ultrastructural imaging, and energy dispersive X-ray elemental analyses were used to examine the lesions. Calcification of the tunica media, predominantly the pulmonary artery, was found in 82% of horses (83/101). Young adult horses (mean [SD] age in years, 4.44 ± 2.17) of both breeds and sexes were similarly affected. Lesions appeared as white-to-yellowish, hard, and gritty plaques of variable size. On microscopic examination, elastic fibers within the tunica media were thinned, fragmented, and calcified, and surrounded by dense collagen matrix. Elemental analysis showed distinct peaks for calcium and phosphorus, consistent with hydroxyapatite mineral. The frequent occurrence of calcification in the tunica media of large pulmonary arteries of young racing horses indicates the need to investigate its pathogenesis and potential clinical implications.
Neuropathology of Italian Cats in Feline Spongiform Encephalopathy Surveillance
Authors: Iulini B. , Cantile C. , Mandara M. T. , Maurella C. , Loria G. R. , Castagnaro M. , Salvadori C. , Porcario C. , Corona C. , Perazzini A. Z. , Maroni A. , Caramelli M. , Casalone C.
Published: August 2008

Feline spongiform encephalopathy (FSE) is a transmissible spongiform encephalopathy associated with the consumption of feedstuffs contaminated with tissue from bovine spongiform encephalopathy-affected cattle and characterized by the accumulation in the central nervous system of an abnormal isoform of the prion protein (PrPsc). Clinically, it presents as a progressive fatal neurologic syndrome that is not easily distinguished from other feline neurologic conditions. Most cases of FSE have been reported in England, where it was first detected in 1990, but a few cases have been reported from other European countries. To identify possible cases of FSE in Italy, the Italian Ministry of Health funded a 2-year surveillance project during which the brains from 110 domestic cats with neurologic signs were evaluated histologically for spongiform encephalopathy and immunohistochemically to detect PrPsc. Although no cases of FSE were found, the study proved useful in monitoring the Italian cat population for other neurologic diseases: neoplasia (21.8%), toxic-metabolic encephalopathy (18.2%), granulomatous encephalitis (15.5%), suppurative encephalitis (4.6%), trauma (3.6%), circulatory disorders (3.6%), degeneration (2.7%), nonsuppurative encephalitis (2.7%), and neuromuscular diseases (1.8%). No histologic lesions were found in 20% of the brains, and samples from 5.5% of the cats were rejected as unsuitable.
Porcine Circovirus 2 Inclusion Bodies in Pulmonary and Renal Epithelial Cells
Authors: Huang Y. Y. , Walther I. , Martinson S. A. , López A. , Yason C. , Godson D. L. , Clark E. G. , Simko E.
Published: August 2008

Porcine circovirus 2 (PCV2) is the cause of postweaning multisystemic wasting syndrome (PMWS). The most common lesions of PMWS are lymphohistiocytic to granulomatous lymphadenitis, interstitial pneumonia and interstitial nephritis, with intracytoplasmic amphophilic botryoid inclusion bodies in macrophages. In addition to these typical changes, intracytoplasmic botryoid inclusion bodies were observed in bronchial, bronchial glandular, and renal tubular epithelium of several pigs from 4 different farms in Western and Eastern Canada. PCV2 inclusion bodies were demonstrated to be located in the cytoplasm of epithelial cells by immunohistochemical staining for PCV2 and cytokeratin antigens and by ultrastructural demonstration of viral particles in the inclusion bodies within renal tubular epithelium.
Systemic Reactive Angioendotheliomatosis-like Syndrome in a Steer Presumed to be Persistently Infected with Bovine Viral Diarrhea Virus
Authors: Breshears M. A. , Johnson B. J.
Published: August 2008

Unusual proliferative intravascular lesions were seen in multiple organs of a 2-year-old Corriente steer presumed to be persistently infected with bovine viral diarrhea virus (BVDV), based on widespread immunohistochemical detection of BVDV antigen. Proliferations of spindle cells, which were immunohistochemically positive for von Willebrand factor-related antigen, partially-to-completely occluded vessel lumens and were supported by cells that were immunohistochemically positive for smooth muscle actin. Distribution and character of the intraluminal proliferations are strikingly similar to those described in feline systemic reactive angioendotheliomatosis, a rare entity of unknown cause. The presence of occasional intravascular thrombi suggests that the proliferative vasculopathy was associated with an underlying thrombotic process with immunohistochemical similarities to thrombotic thrombocytopenic purpura of humans. Death of the steer was due to hemorrhage from a castration wound, which may indicate thrombocytopenia or platelet dysfunction. The role of persistent BVDV infection in the formation of the intravascular lesions is unknown.
Laboratory Findings, Histopathology, and Immunophenotype of Lymphoma in Domestic Ferrets
Authors: Ammersbach M. , DeLay J. , Caswell J. L. , Smith D. A. , Taylor W. M. , Bienzle D.
Published: August 2008

Lymphoma is a common tumor in ferrets, but anatomic distribution, histomorphology, immunophenotype, laboratory abnormalities, and response to chemotherapy are incompletely defined. In this study, lymphoma was diagnosed by histopathology of tumor tissue in 29 ferrets ranging in age from 0.8 to 8.5 years, including 12 males and 17 females. Tumors involved the viscera of the abdominal cavity (n = 11), thoracic cavity (n = 1), or abdominal and thoracic cavities (n = 7); the skin (n = 2); or the viscera of both body cavities plus other sites (n = 8). Microscopically, all tumors had diffuse architecture. Assessment by histomorphology and immunophenotype classified tumors as peripheral T-cell lymphoma (n = 17), anaplastic large T-cell lymphoma (n = 5), anaplastic large B-cell lymphoma (n = 4), diffuse large B-cell lymphoma (n = 1), and Hodgkin-like lymphoma (n = 2). Cytologic evaluation of tumor tissue was diagnostic in 11 of 13 cases. Twenty-two of 27 ferrets had anemia, 2 had leukemia, and 5 were neutropenic. Common comorbid disorders were adrenal disease (n = 27) and insulinoma (n = 6). Tumors most frequently involved mesenteric lymph nodes, while enlargement of peripheral lymph nodes was uncommon (n = 3). Ferrets with Hodgkin-like lymphoma had massive enlargement of single lymph nodes. Mean survival of ferrets not immediately euthanized was 5.0 months (T-cell lymphoma) and 8.4 months (B-cell lymphoma). Ferrets treated with chemotherapy survived an average of 4.3 months (T-cell lymphoma, n = 9) or 8.8 months (B-cell lymphoma, n = 4). Results indicate that lymphomas in ferrets most commonly affect abdominal viscera, may be amenable to cytologic diagnosis, are frequently associated with anemia and, in some cases, may be chemosensitive, resulting in relatively long survival times.
Naturally Occurring Multiple Perineuriomas in a Chicken (Gallus domesticus)
Authors: Ochi A. , Ochiai K. , Hatai H. , Umemura T.
Published: August 2008

A 2-year-old, male Japanese native fowl ( Gallus gallus domesticus) was presented with an inability to feed and torticollis. At a necropsy, there were cylindrical enlargements and yellow discoloration of multiple peripheral nerves, including nerves of the lumbosacral plexus, brachial plexus, and spinal ganglia. On histologic examination, these lesions consisted of diffuse proliferations of spindle cells with characteristic onion bulb-like structures around residual axons. The spindle cells were immunohistochemically positive for glucose transporter 1 (GLUT1) and negative for S-100 α/β proteins. On the basis of microscopic, histologic, and immunohistochemical findings, the tumors were diagnosed as multiple perineuriomas.
Ganglioneuroma of the Brachial Plexus in Two Cockatiels (Nymphicus hollandicus)
Authors: Murphy B. G. , Shivaprasad H. L.
Published: August 2008

Ganglioneuroma involving the brachial plexus, paraspinal ganglia, and cervical-thoracic spinal cord was diagnosed in 2 adult cockatiels ( Nymphicus hollandicus). Both birds had a chronic 1-year history of ataxia and perching difficulty. At necropsy, each bird had a unilateral, firm, gelatinous white to tan multilobular mass at the thoracic inlet expanding and partially obliterating the brachial plexus and cervical spinal cord. Histologically, the masses were characterized by a locally infiltrative neoplasm comprised of spindloid cells forming streams and sheets with interspersed distinct neuron cell bodies consistent with ganglion cells. The spindloid cell population was immunohistochemically positive for neurofilament protein in one of the birds.
Antidepressant Prescription and Suicide Rates: Effect of Age and Gender
Authors: Kalmar Sandor , Szanto Katalin , Rihmer Zoltan , Mazumdar Sati , Harrison Katrin , Mann J. John
Published: August 2008

To determine whether the effect of antidepressant exposure on suicide rate is modified by age and gender in Hungary, annual antidepressant prescription rates and suicide rates of about 10 million inhabitants between 1999–2005 were analyzed by age and gender groups. The suicide rate was inversely related to the increased use of antidepressants in both genders. The strongest association was found in the oldest age groups, where the increase in antidepressant use was highest, while there was no association in the under 20 or 50–69 age groups in either gender. Antidepressant prescription rate was related to suicide rate after controlling for divorce rate or unemployment rate, but not after controlling for alcohol consumption rate.
What do Suicide Survivors Tell Us They Need? Results of a Pilot Study
Authors: Mcmenamy Jannette M. , Jordan John R. , Mitchell ANN M.
Published: August 2008

Few studies have examined the natural coping efforts used by suicide survivors, or have identified specific problems and needs survivors experience following the death of a significant other by suicide. In the present study, we used a newly developed needs assessment survey to examine four areas of natural coping efforts: practical, psychological, and social difficulties; formal and informal sources of support; resources utilized in healing; and barriers to finding support since the loss. Sixty‐three adult survivors of suicide were recruited from suicide survivor conferences and support groups. Results indicate that participants experienced high levels of psychological distress since the suicide, including elevated symptoms of depression, guilt, anxiety, and trauma. Participants experienced substantial difficulties in the social arena (e.g., talking with others about the suicide). The majority of the sample viewed professional help as beneficial; although many informal sources of support were also valued (e.g., one‐to‐one contact with other survivors). Depression and a lack of information about where to find help served as barriers to help‐seeking behaviors for our participants. Participants who reported higher levels of functional impairment were more likely to report higher levels of psychological distress, social isolation, and barriers to seeking help. Future research with a longitudinal and more inclusive sample is needed to build on these preliminary findings and to provide a solid foundation for evidenced‐based interventions with survivors.
Correlates of Suicidality Among Patients with Psychotic Depression
Authors: Schaffer Ayal , Flint Alastair J. , Smith Eric , Rothschild Anthony J. , Mulsant Benoit H. , Szanto Katalin , Peasley‐Miklus Catherine , Heo Moonseong , Papademetriou Eros , Meyers Barnett S.
Published: August 2008

The independent association of age and other factors with suicidality in patients with major depression with psychotic features was examined. Of the 183 study participants, 21% had a suicide attempt during the current episode. Male gender, Hispanic background, past suicide attempt, higher depression scores, and higher cognitive scores were each independently associated with greater intensity of current suicidality. Older age was independently associated with a lower risk of a lifetime suicide attempt. These findings reinforce the evidence that patients with psychotic depression are at high risk for suicide and underscore the importance of examining correlates of suicidality specific to patients with psychotic depression.
Current Suicide Proneness and Past Suicidal Behavior in Adjudicated Adolescents
Authors: Langhinrichsen‐Rohling Jennifer , Lamis Dorian A.
Published: August 2008

Youth recently assigned to probation (n = 233) were assessed for current suicide proneness, depression, and hopelessness, as well as for recent suicide ideation, previous suicide ideation, or suicide attempt(s). The Life Attitudes Schedule‐Short Form (LAS‐SF) was used to assess suicide proneness. As per the LAS‐SF, suicide proneness was defined broadly to include current engagement in overtly suicidal behavior as well as in risk‐taking and potentially injury‐producing behaviors, coupled with a lack of engagement in health and safety behaviors, or self‐enhancement behaviors. As expected, current suicide proneness was significantly associated with a history of suicide ideation and attempts, recent ideation, and current depression and hopelessness for adjudicated youth. Gender differences were obtained between the strength of the association between suicide proneness and depressive symptoms. A subgroup of adjudicated youth (n = 39) was then interviewed about their suicidal behaviors. Among other things, these youth indicated that the majority of their previous suicide attempts were committed impulsively.
Social and Racial Correlates of Russian Roulette
Authors: Stack Steven , Wasserman Ira
Published: August 2008

The epidemiology of a neglected form of suicidal behavior, Russian roulette, is addressed. Also tested is an explanation of racial differences based on the opportunity theory of deviant behavior related to the availability of revolvers, necessary weapons with which to play Russian roulette. Data refer to 15 cases of Russian roulette found through a search of the medical examiner's suicide files (N= 1,412) and 75 matched controls who suicided by a gunshot to the head. The results support an opportunity perspective: 80% of the Russian roulette victims were African American compared to 30.7% of the controls. Further, among the controls, Blacks were three times more likely than Whites to use revolvers in suicides, a pattern indicating Blacks' greater access to revolvers. Russian roulette victims were entirely male, significantly younger, and less apt to be married than the control group.
Identifying the Risk of Deliberate Self‐Harm Among Young Prisoners by Means of Coping Typologies
Authors: Kirchner Teresa , Forns Maria , Mohíano Susana
Published: August 2008

Self‐harming behavior during incarceration has been a topic of increasing attention in recent years. Some authors attribute these episodes to the high level of stress that imprisonment generates coupled with a low quality of coping strategies employed by inmates. The main aim of this study was to identify, by means of coping typologies, prisoners at higher risk of self‐harming behavior. The results highlighted the fact that coping typologies permitted the classification of inmates into four groups and the identification of those at lower and higher risk of self‐harming. The group at greater risk was the one that used more avoidance and less approach coping.
Inpatient Suicide in a Chinese Psychiatric Hospital
Authors: Li Jie , Ran Mao‐Sheng , Hao Yuantao , Zhao Zhenhuan , Guo Yangbo , Su Jinghua , Lu Huixian
Published: August 2008

Little is known about the risk factors for suicide among psychiatric inpatients in China. In this study we identified the risk factors of suicide among psychiatric inpatients at Guangzhou Psychiatric Hospital. All psychiatric inpatients who died by suicide during the 1956–2005 period were included in this study. Using a case‐control design, 64 inpatients with schizophrenia who died by suicide were compared with a matched 64 controls. The results indicate that the rate of suicide was 133.1/100,000 admissions (95%CI 103.4–162.9). There were no significant differences in the method, location, or time of suicide between male and female inpatients. The number of hospitalizations was significantly larger in the suicide group than that in the control group. In logistic regression analyses, guilty thought, depressive mood, and suicidal ideation and suicide attempt 1 month before hospital admission were identified as independent predictors of suicide among inpatients with schizophrenia. The findings of risk factors for schizophrenic inpatient suicide should be taken into account when developing interventions to prevent suicide among these patients.
Socio‐Cultural Features and Sex Profile of the Individuals with Serious Suicide Attempts in Southeastern Turkey: A One‐Year Survey
Authors: Yasan Aziz , Danis Ramazan , Tamam Lut , Ozmen Sehmus , Ozkan Mustafa
Published: August 2008

Our objective was to elucidate potential causes of higher rates of suicide attempts in females compared to males in southeastern Turkey through a 1‐year survey. Gender‐related differences observed in 96 subjects who attempted suicide by poisoning for the first time were as follows: in comparison to male, females were predominantly within the age interval of 15–24 years, experienced more stressful events in the previous week before suicide attempt, had lower education level, and had a lower rate of employment. One year after the suicide attempt, unfavorable attitude of family, lack of support, persisting unfavorable lifestyle comparable with that prior to the first attempt, and higher rates of domestic violence were more pronounced in females compared to males. These findings might be contributing factors to the higher suicide attempt rates observed in females compared to the males.
Both the Establishment and Maintenance of Neuronal Polarity Require the Activity of Protein Kinase D in the Golgi Apparatus
Authors: Yin Dong-Min , Huang Yan-Hua , Zhu Yan-Bing , Wang Yun
Published: August 2008

Neuronal polarization requires coordinated regulation of membrane trafficking and cytoskeletal dynamics. Several signaling proteins are involved in neuronal polarization via modulation of cytoskeletal dynamics in neurites. However, very little is known about signaling proteins in the neuronal soma, which regulate polarized membrane trafficking and neuronal polarization. Protein kinase D (PKD) constitutes a family of serine/threonine-specific protein kinases and is important in regulating Golgi dynamics and membrane trafficking. Here, we show that two members of the PKD family, PKD1 and PKD2, are essential for the establishment and maintenance of neuronal polarity. Loss of function of PKD with inhibitor, dominant negative, and short interfering RNA disrupts polarized membrane trafficking and induces multiple axon formation. Gain of function of PKD can rescue the disruption of polarized membrane trafficking and neuronal polarity caused by cytochalasin D, which results in F-actin depolymerization. PKD1 and PKD2 are also found to be involved in the maintenance of neuronal polarity, as evidenced by the conversion of preexisting dendrites into axons on PKD inhibition. Unlike other polarity proteins, PKD does not interact with the cytoskeleton in neurites. Instead, PKD regulates neuronal polarity through its activity in the Golgi apparatus. These data reveal a novel mechanism regulating neuronal polarity in the Golgi apparatus.
Temporary Activation of Long-Term Memory Supports Working Memory
Authors: Lewis-Peacock Jarrod A. , Postle Bradley R.
Published: August 2008

This study describes a functional magnetic resonance imaging study of humans engaged in long-term memory (LTM) and working memory tasks. A pattern classifier learned to identify patterns of brain activity associated with viewing and making judgments about three categories of pictures (famous people, famous locations, and common objects). The evaluation of these stimuli relied on perception and long-term semantic and/or episodic memories. We investigated whether this classifier could successfully decode brain activity from a subsequent delayed paired-associate recognition working memory task that required the short-term retention of the same stimuli. We reasoned that the LTM-trained classifier would be able to decode delay-period activity only if that activity reflected, to some extent, the temporary activation of LTM. Our results demonstrated successful decoding: delay-period activity from a distributed network of brain regions matched learned patterns of activity for task-relevant stimuli to a greater extent than for task-irrelevant stimuli. In varying degrees throughout the delay, activity reflected the target (a retrospective code) and its associate (a prospective code) with considerable variability among subjects. Although prefrontal cortex (PFC) demonstrated category-specific patterns of activity during the LTM task, these patterns were not reinstated in PFC during the working memory task. We conclude that the short-term retention of information can be supported by the temporary reactivation of LTM representations.
Sandblasted/Acid-Etched vs Smooth-Surface Implants: Implant Mobility and Clinical Reaction to Experimentally Induced Peri-Implantitis in Beagle Dogs
Authors: Martines Rodrigo Tadashi , Sendyk Wilson Roberto , Gromatzky Alfredo , Cury Patricia Ramos
Published: August 2008

This study uses a sandblasted/acid-etched implant vs a smooth-surface implant to compare implant mobility and clinical reactions of peri-implant tissues to experimentally induced peri-implantitis in Beagle dogs. The right and left mandibular premolars were extracted from 5 Beagle dogs, and 2 smooth-surface (SS) implants and 2 sandblasted/acid-etched (SLA) implants were placed in each animal. After 120 days, healing abutments were connected. Fifteen days later, the prosthetic abutments were connected, the hygiene regimen was suspended, and peri-implantitis was induced by the insertion of cotton ligatures into the soft tissue around the implants. At baseline and 30, 60, and 90 days later, clinical attachment level (CAL), probing depth (PD), and mobility (MO) were measured. Probing depth increased significantly in the SLA group alone when baseline PD was compared with 30-, 60-, and 90-day evaluations (P < .05). No significant differences were noted between the 2 implant groups (P > .05). The loss in CAL was significant in both groups when the baseline value was compared with 30-, 60-, and 90-day evaluations (P < .02). Comparison between the 2 implant groups revealed a greater loss in CAL in the SLA group at the 90-day evaluation period (P = .04). A significant increase in mobility was seen in both groups when baseline values and 90-day evaluations were compared (P < .04). However, no statistically significant differences were noted between the 2 implant groups (P > .05). Experimentally induced peri-implantitis results in a greater loss of CAL in SLA implants than in SS implants in dogs; however, no differences in mobility or in PD have been noted between the 2 implant groups.
Single-Tooth Replacement in the Esthetic Zone With Ridge Expansion Osteotomy: A Clinical Report and Radiographic Results
Authors: Santagata Mario , Guariniello Luigi , D'Andrea Alfredo , Tartaro Gianpaolo P.
Published: August 2008

Maxillary alveolar atrophy often limits the placement of dental implants. The bone splitting and bone widening by osteotome technique is a more obvious method for the immediate placement of implants in those cases in which the dimensions of the residual ridge are reduced by only a small degree. Few studies have been performed that are aimed at the radiographic results shown after the osteotome technique by a low-dose computed tomography scan and assessment of objective improvement of the bone density using Misch's classification. The aim of this clinical case was to analyze the radiographic data of the osteotome technique on the change of bone density and to demonstrate efficacy of the ridge expansion crest to bypass bone fenestrations of the buccal plate in the esthetic zone. The advantages of this technique for patients include less surgical trauma and a shorter treatment time.
Immediate Loading of Single-Tooth Restorations: One-Year Prospective Results
Authors: Siddiqui Azfar A. , O'Neal Robert , Nummikoski Pirkka , Pituch Daniel , Ochs Mark , Huber Heidi , Chung William , Phillips Keith , Wang I-Chung
Published: August 2008

Immediate loading of splinted implant restorations is a growing trend, but limited clinical documentation hampers evidence-based treatment planning for single-tooth applications. This study prospectively evaluated the clinical efficacy of placing implant-supported, single-tooth restorations into immediate, full-occlusal loading. Sixty consecutive patients (intent-to-treat group) with 1 missing tooth between 2 intact teeth were treated with a total of 69 implants. At placement, final impressions were made and implants were provisionalized with nonoccluding prostheses. Definitive prostheses were delivered 2 weeks later. A claim of noninferiority was made with a 95% confidence interval (Mann-Whitney U test) if the success rates between the experimental group and a 97% historical control was >7%. Standardized radiographs taken at placement and bimonthly intervals were analyzed for crestal bone changes at a type I (alpha) error level of .05; significance levels were not adjusted for multiplicity (Fisher exact tests and Student t tests). Sixteen patients (18 implants) were withdrawn for protocol deviations. The resulting treated-per-protocol group consisted of 44 subjects with 51 implants. Cumulative implant success rates were 98.55% (n = 68/69) for the intent-to-treat group and 98.04% (n = 50/51) for the treated-per-protocol group. There were no significant adverse events or statistically significant differences between the experimental and historical control groups. At 12 months mean crestal bone loss was 1.05 mm, and ranged from 0.38 to 1.5 mm (77%) and 1.6 to 2.69 mm (23%). Immediate full-occlusal loading of single-tooth restorations was safely performed in selected subjects when good primary implant stability and an appropriate occlusal load were achieved.
Coaster Brook Trout Rehabilitation in Lake Superior: A Human Dimensions Perspective
Authors: Hewitt Laura E. , Mumford Karen G. , Schreiner Donald R. , Fischer Gregory J.
Published: August 2008

Rehabilitation of Lake Superior's coaster brook trout Salvelinus fontinalis hinges not only on resolving critical ecological challenges but also on addressing key human dimensions challenges. This article addresses the key issues of values, agency coordination, stakeholder engagement, and public awareness and outreach and makes relevant recommendations. First, agencies should continue to improve coordination by expanding the scope and membership of the Lake Superior Brook Trout Committee and other forums. The size of the basin and the large number of partners involved requires consistent communication and transparent coordination mechanisms. Second, the range of values currently associated with brook trout and their rehabilitation must be expanded beyond the current focus on fishery interests by incorporating a more diverse array of groups and interests. Third, the number of groups engaged in native brook trout restoration efforts should be enlarged by reaching out to new groups, particularly watershed organizations, local governments, and environmental groups, as the comprehensive nature of the restoration efforts will require the cooperation and support of a broader array of groups. Finally, the level of general public awareness and support for the activities necessary to rehabilitate coasters needs to be increased. An outreach program should engage all stakeholders early in the planning process and provide science-based information to establish reasonable expectations. Fishery managers and their partners should look for opportunities to bring positive attention to ongoing rehabilitation and habitat management activities.