bluuebunny/crossref_metadata_2025 huggingface dataset:
Early Efficacy of Type I Collagen Based Matrix-Assisted Autologous Chondrocyte Transplantation to Treat Articular Cartilage Lesions
Authors: Li Xiang , Qian Jiatian , Li Shiao , Fu Peiliang , Chen Chengyan
Published: May 2021

Purpose: To investigate the clinical, radiological, and histological results of type I collagen-based matrix-assisted autologous chondrocyte transplantation (MACT) in the treatment of chondral lesions of the knee.Methods: The study prospectively enrolled 20 patients with symptomatic knee chondral defects (mean size defect was 2.41±0.43 cm2, range 2.0 to 3.4 cm2) in the lateral femoral condyle and femoral groove who underwent type I collagen-based MACT between July 2017 and July 2019. KOOS was assessed preoperatively, with periodic clinical follow-up performed preoperatively and then every 3 months for up to 12 months postoperative period, and thereafter at 1-year intervals. During this follow-up, serial magnetic resonance imaging T2 mapping of repair cartilage was used to reflect the quantitative analysis quality of the regenerative cartilage. In one patient, second-look arthroscopy was performed at 12 months after implantation to assess the characteristics of cartilage regeneration.Results: Compared with preoperation, the score of the pain, symptoms, activities of daily living, sports and recreation, and quality of life showed statistically significant improvement with a significant difference at 3, 6, 12, and 24 months after operation(P<0.05). The difference in KOOS subscales scores between every two-time point was statistically significant (P<0.001). HE stains showed the newly formed cartilage was naive chondrocytes. Safranin O-fast green stain manifested in the regenerated tissue comprising predominantly fibroblast-like cells surrounded by glycosaminoglycans. Immunohistochemistry analysis showed that the expression of collagen type II was more clearly and evenly distributed than collagen type I.Conclusion: Type I collagen-based MACT was a clinically effective treatment for functional and pain level improvement, and this method presented histologic evidence of inducing hyaline‐like cartilage in cartilage lesions by biopsy in one case. The quantitative MRI T2-mapping test showed that there was a difference between the transplanted cartilage and the surrounding hyaline cartilage.
Prevalence and Factors Associated With Stunting Among Children Aged 6-59 Months in Kabale District, Uganda
Authors: Kasajja Musa , Nabiwemba Elizabeth , Wamani Henry , Kamukama Saul
Published: May 2021

Background: Despite of the global efforts undertaken to improve nutrition, malnutrition still continues to be a serious public health concern. Malnutrition in its various forms has been closely associated to major causes of illness, disability and death. Malnutrition in the form of childhood stunting has therefore been identified as a significant hindrance to human development. The aim of this study was to assess the nutritional status of children aged 6–59 months and determine factors associated with stunting among children in Kabale district. Methodology: A cross sectional study was conducted among 640 children, aged 6–59 months selected using both simple random and systematic random sampling techniques. Interview administered questionnaires were used to collect household data whereas anthropometric data was collected using a height board, digital weighing scales and Mid Upper Arm Circumference (MUAC) Tapes. Data was analyzed using STATA version 12.0 and ENA for SMART, 2011. Results: The overall prevalence of stunting among children 6-59 months was 41.1%. Factors independently associated with stunting included; age of the child (children in the age category of 36-47months APOR=0.38; 95% CI 0.18-0.79 and those in the age category of 24-35months APOR=0.42; 95% CI 0.19-0.88), major source of food for the household that is children from households in which mothers indicated market as the major source of food (APOR=0.67; 95% CI 0.48-0.94) and disposal of child stool that is children whose stool was put/ rinsed in a latrine (APOR=0.41; 95% CI: 0.23-0.74) as well as those that whose stool was thrown in garbage (APOR= 0.29; 95% CI: 0.12-0.72). Conclusion: The prevalence of stunting among children aged 6-59 months in Kabale district was high. Practices/ factors independently associated with stunting among children aged 6-59months included; age of the child, major source of food for the household and disposal of child stool. Addressing these factors requires a proper mix of both community and health based interventions. There is also need to strengthen on strategies for reducing stunting like; sanitation and hygiene as well as food and nutrition security within rural households.
A Study on the Soundscape Satisfaction Degree of Urban Landscape Garden Parks
Authors: Di Guoqing , Xiang Junli , Yao Yao , Chen Cong , Lin Qinhao
Published: May 2021

Establishing a public response model of soundscape in parks can provide a basis for the optimization of soundscape design. Three representative urban landscape garden parks were selected in Hangzhou, in which a number of evaluation points were chosen along soundwalk paths. Binaural sounds at each evaluation point were sampled by an artificial head and the landscapes of horizontal view and vertical view were obtained by panoramic photos and satellite images, respectively. An evaluation on soundscape of each point was conducted in laboratory based on virtual reality technology, and the correlations between 17 acoustic indicators, 35 landscape indicators and soundscape satisfaction degree were analyzed. The public response model of soundscape satisfaction degree in parks was established. Final indicators entering the model were the loudness level of sound, the aggregation index of water, the largest patch index of water and the landscape shape index of roads, and their standard regression coefficients were -0.666, - 0.561, 0.523 and -0.310, respectively. The impact weights of acoustics and landscape factors on the satisfaction were 32.3% and 67.7%. When the percentage of vegetation area in park exceeds 15%, its contribution to satisfaction degree will be close to a fixed value (reflected in the constant term of the model). The soundscape satisfaction can be effectively improved by reducing the loudness level of sound in parks, increasing the area of the largest water patch with scattered water patches around it, and reducing the shape complexity of road patches.
Impact of Cavotricuspid Isthmus Anatomy on the Ablation Index For Successful First-Pass Typical Atrial Flutter Ablation
Authors: Kashiwagi Manabu , Kuroi Akio , Katayama Yosuke , Terada Kosei , Fujita Suwako , Hozumi Takeshi , Shimamura Kunihiro , Shiono Yasutsugu , Tanimoto Takashi , Kubo Takashi , Tanaka Atsushi , Akasaka Takashi
Published: May 2021

Cavotricuspid isthmus (CTI) linear ablation has been established as the treatment for typical atrial flutter. Recently, ablation index (AI) has emerged as a novel marker for estimating ablation lesions. We investigated the relationship between CTI anatomy and ablation parameters. In addition, we focused on the influence of AI on the procedural results of typical atrial flutter ablation. A total of 107 patients who underwent CTI ablation were retrospectively enrolled in this study. All patients underwent computed tomography before catheter ablation. From the receiver-operating curve, the best cut-off value of CTI depth was < 4.1 mm to predict first-pass success. The patients were divided into two groups according to the CTI depth: the concave group (CG) and straight group (SG). Although the average AI was not different between both groups, the CG required a longer ablation time and showed a lower first-pass success rate (p < 0.01). In addition, the catheter inversion technique was more frequently required in the CG (p < 0.01). The best cut-off values of the weakest AIs at the anterior and posterior lesions for predicting first-pass success were >420 and >386, respectively. Among patients with these cut-off values, the first-pass success rate was 88% in the SG and 50% in the CG (p < 0.01). Although ablation parameters were not significantly different, the first-pass success rate was lower in the CG than in the SG. AI-guided CTI may be useful in straight CTIs, but a modified approach might be required for concave CTIs.
Single-Cell Analysis of Tumor-Specific Neutrophils During Gastric Cancer Progression Inspired a Hippo Targeted Antitumor Therapy
Authors: Jiao Shi , Nie Pingping , Zhang Weihong , Meng Yang , Guo Fenghua , Zhang Hui , Tong Zhenzhu , Wang Meng , Chen Fan , An Liwei , Han Yi , Wang Wenjia , Wei Lixin , Zhou Zhaocai
Published: May 2021

Neutrophils are important for tumor immunosurveillance; yet their roles in tumorigenesis remain debating due to incomplete understanding of their heterogeneity and functional plasticity. Here we resolve at single-cell resolution the heterogeneity of neutrophils in tumor-bearing mice and patients with gastric cancer. Our results define CXCR2negCD44neg neutrophils as a tumor-specific (tsNeu) population with activated (CD14high) but atavistic phenotypes (CD53highCD63high). Human and mouse tsNeus can be further classified into four subsets according to their expression of CD54 and CD101. Importantly, the spatiotemporal evolution and anti-tumor function of tsNeu requires the Hippo pathway transcriptional co-activator YAP/TAZ. Deficiency of YAP/TAZ impairs the generation of effective tsNeus and therefore accelerates tumor progression. Remarkably, treatment with the Hippo antagonist phosphatidic acid (PA) turns blood neutrophils into tsNeus with enhanced abilities of direct killing tumor cells, as well as inducing adaptive anti-tumor immunity. Collectively, our work not only identified molecular makers for tsNeus, but also revealed key transcriptional programs for their fate determination and function; and further offers a strategy of targeting Hippo-YAP/TAZ for neutrophil therapy against gastric cancer.
Association of Toll-Like Receptor 9 Gene Polymorphisms With Remission in Patients With Rheumatoid Arthritis Receiving Tumor Necrosis Factor Alpha Inhibitors and Development of Machine Learning Models
Authors: Kim Woorim , Kim Tae Hyeok , Oh Su Jin , Kim Hyun Jeong , Kim Joo Hee , Kim Hyoun-Ah , Jung Ju-Yang , Choi In Ah , Lee Kyung Eun
Published: May 2021

Studies that investigate the association between toll-like receptor (TLR)-4 or TLR9 gene polymorphisms and remission from the disease in RA patients taking tumor necrosis factor alpha (TNF-α) inhibitors have yet to be conducted. In this context, this study was designed to investigate the effects of polymorphisms in TLR4 and TLR9 on response to TNF-α inhibitor and develop various machine learning approaches to predict remission. A total of six single nucleotide polymorphisms (SNPs) were investigated. Logistic regression analysis was used to investigate the association between genetic polymorphisms and response to treatment. Various machine learning methods were utilized for prediction of remission. After adjusting for covariates, the rate of remission of T-allele carriers of TLR9 rs352139 was about 5 times that of the CC-genotype carriers (95% confidence interval (CI) 1.325–19.231, p = 0.018). Among machine learning algorithms, multivariate logistic regression and elastic net showed the best prediction with the AUROC value of 0.71 (95% CI 0.597 - 0.823 for both models). This study showed an association between a TLR9 polymorphism (rs352139) and treatment response in RA patients receiving TNF-α inhibitors. Moreover, this study developed various machine learning methods for prediction, among which the elastic net provided the best model for remission prediction.
Isolation and Characterization of a Bacteriophage Infecting Pseudomonas Aeruginosa and Its Application as a Potential Decontaminating Agent
Authors: Sharma Sonika , Datta Sibnarayan , Chatterjee Soumya , Dutta Moumita , Samanta Jhuma , Vairale Mohan G , Gupta Rajeev , Veer Vijay , Dwivedi Sanjai K
Published: May 2021

To treat antibiotic resistance bacteria, bacteriophage (also called 'phage') application has recently drawn considerable attention from researchers globally. Bacteria like Pseudomonas aeruginosa are known to be associated with nosocomial infections especially in patients with compromised immune systems. In the present work, phage against P. aeruginosa (named 'DRLP1') was isolated from wastewater, enriched and characterized. Morphologically DRLP1 belongs to the family Myoviridae with a high lytic ability. DRLP1 has a burst size of approximately 100 PFU/infected cells, a rapid adsorption time when supplemented with MgCl2, and has viability in a wide temperature range and pH. Genomic sequencing and bioinformatics analysis showed that the phage genome is linear double-stranded, 66,243 bp in length and have a GC content of 54.9%. the genome encodes 93 phage related ORFs open reading frames (ORFs). Phage stability in lyophilized state, adsorption study on sodium alginate beads, and in-vitro pathogen reduction assays were also investigated. Study carried out with artificially contaminated fomites suggests that this phage has the potential for application as a biological decontaminant agent against P. aeruginosa in different conditions.
Sonic irrigation for removal of calcium hydroxide in the apical root canal: A micro-CT and light-coupled tracking analysis
Authors: Moon Wonjoon , Chung Shin Hye , Chang Juhea
Published: May 2021

This study aimed to evaluate the efficacy of three sonic irrigation systems for removal of calcium hydroxide dressing from the apical root canal. A total of 96 single-rooted teeth in three categories of root canal curvatures (straight: 0–5⁰, moderate: 6–20⁰, and severe: > 20⁰ were allocated to four groups: conventional needle irrigation, EndoActivator, EQ-S, and Vibringe. The root canals were instrumented using Protaper NEXT and filled with calcium hydroxide. After removal of calcium hydroxide, the remaining volume of calcium hydroxide was measured by micro-CT analysis. Data were compared among root canal curvatures and irrigation systems using the Kruskal-Wallis test and Mann-Whitney test (p < .05). The oscillating range of each irrigation system was measured using light-coupled motion tracking. The volumes of calcium hydroxide remained in the canals of severe curvature were significantly lower than in those of straight curvature (p < .05). In the canals of moderate or severe curvature, EQ-S showed the highest removal percentage, followed by EndoActivator, Vibringe, and needle irrigation (p < .05). Light-coupled tracking showed the largest oscillating range in EQ-S (p < .05). Sonically activated irrigation systems with a flexible tip can be beneficial for cleaning of intracanal medication in the curved apical canals.
Cytopathic Effect of Vero Cells Adapted Bangladeshi Strain of Peste Des Petits Ruminants (PPR) Virus in Cell Culture
Authors: Siddiqui MSI , Globig Anja , Hoffmann Bernd , Islam MN , Islam  , Chowdhury EH
Published: May 2021

The present study described the cytopathic effect of PPR virus presently being used in serial passages at level of 60th in Vero cells and infected tissue culture fluid was used in this study as viral inoculum. Vero cells were grown on cover slip & were infected with tissue culture fluid at a fixed multiplicity of infection (MOI) 0.01. The infected cover slip along with control were stained with H&E stain at periodic intervals and cytopathic effect was studied with microscope. The cytopathic effect (CPE) was visible at first from 24 hpi and the Vero cells showed initial cell rounding, aggregation and syncytial development. Development of inclusion bodies and cell degradation was noticed by 72 hpi. Complete detachment of the cell monolayer was observed by 84 hpi. It is concluded that, development of numerous inclusion bodies is the indication of well adaptation & extensive multiplication of PPRV in Vero cells.
Effects of Fertilisation on Grass and Forb Gamic Reproduction in Semi-natural Grasslands
Authors: Scotton Michele , Rossetti Valentina
Published: May 2021

Studying the effects of fertilisation on the seed production of grassland species can help understand the vegetation changes and biodiversity losses due to soil eutrophication. On a temperate hay-meadow, the seed production of fifteen grasses and seventeen forbs was studied under three fertilisation treatments: 0-0-0, 0-54-108 and 192-108-216 kg N, P2O5 and K2O respectively, per year. Fertile shoots collected at the seed maturation stage were analysed for all main traits of the gamic reproduction. On average, forbs produced more ovules and viable seeds per shoot (199 and 65, respectively) than grasses (112 and 35, respectively). Fertilisation increased the number of inflorescences per shoot in both grasses and forbs and had a limited but variable effect on germinability and viability in the two functional groups: viability increased in grasses but often decreased in forbs. This pattern resulted in 55% and 11% increases in viable seed production in grasses and forbs, respectively. At the higher level of fertilisation, shoot density was positively related to the number of viable seeds per shoot in grasses and to the seed size in forbs. Higher grass seed dormancy likely allowed for later grass seed germination in autumn when vegetation cover was low, contributing to the dominance of a few light-seeded nutrient-demanding grasses and poor forb number in fertilised meadows.
An Energetic Cognitive Radio Network Communication Principles with Attack Identification Strategies using Game Theory
Authors: S Thanga Revathi , A Gayathri , J Kalaivani , M Manickam , K Kalaiselvi , K Deepa Thilak
Published: May 2021

In a wireless communication industry Cognitive Radio Network is the most important concern to deal with long range communications in efficient manner with futuristic remote sensing and channel allocation policies. This kind of communication principles need to tackle the attacks in wide manner. Generally, the attacks come from the intruder end with several variations but the most common attacks are network sniffing, route trapping and so on, but in the case of Cognitive Radio Network the major threat is called Primary User Impersonation (PUI). This kind of PUI attacks acts like a regular Primary User (PU) and raise a signals accordingly to make confuse the Secondary Users to come out from the communication line as well as the entire communication spectrum utilized by the Secondary User gets affected. Due to these kinds of affections the legitimate Secondary Users suffer and left from the respective channels utilized for communication. This type of attacks highly creates an impact over the Cognitive Radio Network and causes the failure over spectrum accessing. The flexible accessibility by some voluntary users maintains a constant selection of actions to determine their appropriate target, so they can differentiate between accomplishing their objectives and being compliant with their goals. The critical role is protected against obstruction and moreover mandated by vitality criteria. At the aim to develop energy saving and power gathering cooperative spectrum, factors that are central to the success of the project must be suggested in the literature as two major protocols, such as: Time Sharing (TS) and Energy Sharing (ES). An energy utilization constraint restriction is imposed on the power cells (battery) to make sure they do not charge and discharge at around the parallel period Primary User Impersonation detection in an efficient manner, in which it uses recent advancements in cooperative spectrum sensing to devise an algorithm called Energetic Cognitive Radio Network Game Planner (ECRNGP). A Game Theory logic provides an intelligent attack identification abilities to the proposed approach to identify the threat signals immediately and notify that to the respective transmitter unit to make appropriate preventive measures for that as well as this proposed approach efficiently identifies the Primary User Impersonation and provides a sufficient protection to the CRN environment as well as Secondary Users to make a perfect communication between entities without any attack oriented constraints.
Associations Among Coagulation-Related Variables, Resolution of Disseminated Intravascular Coagulation (DIC), and Mortality in Patients with Sepsis-Induced DIC Treated with Recombinant Human Soluble Thrombomodulin: A Retrospective Observational Study
Authors: Mitaka Chieko , Kawagoe Izumi , Satoh Daizoh , Hayashida Masakazu
Published: May 2021

Background: We evaluated associations among coagulation-related variables, resolution of disseminated intravascular coagulation (DIC), and mortality in patients with sepsis-induced DIC treated with recombinant human soluble thrombomodulin (rTM). Methods: We retrospectively investigated patients with sepsis-induced DIC treated with rTM. Changes in coagulation-related variables before and after treatment with rTM were examined. Further, associations between coagulation-related variables and DIC resolution were evaluated. Results: A total of 123 patients were included. The platelet count, prothrombin international normalized ratio (PT-INR), and fibrin/fibrinogen degradation products (FDP) significantly (p < 0.001) improved after rTM administration in survivors (n = 98), but not in nonsurvivors (n = 25). However, the DIC score significantly (p < 0.001) reduced not only in survivors but also in nonsurvivors. PT-INR before rTM was significantly (p = 0.0029) lower in patients attaining than not attaining DIC resolution (n = 87 and 36, respectively). The 28-day mortality was significantly lower in patients attaining than not attaining DIC resolution (11.5% vs. 41.7 %, p = 0.0001).Conclusions: The DIC score significantly reduced after rTM in both survivors and nonsurvivors. rTM might play an important role in improving DIC, especially when treatment with rTM is initiated in the early phase of DIC.
Development of IMBs-qPCR Detection Method for Yersinia enterocolitica Based on the foxA Gene
Authors: Shi Jingxuan , Chi Heng , Cao Aiping , Song Yinna , Zhu Min , Zhang Linlin , Xu Fuzhou , huang jinhai
Published: May 2021

Yersinia enterocolitica is an important zoonotic pathogen, which seriously endangers food safety risk. In this study, the recombinant outer membrane protein OmpF and its antibody were prepared and coupled with immunomagnetic beads (IMBs) to capture Y. enterocolitica in food samples, combining the quantitative PCR detection with primers of virulence factor gene fox A for Yersinia enterocolitica contamination. The results showed that the capture efficiency of approximately 80% using anti-OmpF antibody-immunomagnetic beads and linearly dependent capture under 10 1 -10 5 CFU/mL Y. enterocolitica . compare with less than 10% capture of other bacteria. The detection limit of 64 CFU/mL was obtained by based on fox A gene PCR detection combined with capture of the anti-OmpF antibody-immunomagnetic beads to detect Yersinia enterocolitica in artificially contaminated milk and pork samples. Comparing with the culture method, the developed IMBs-qPCR method has higher consistency, less time consuming, which providing an effective alternative method for rapid detection of Y. enterocolitica in food.
Respiratory and Cardiovascular Health Effects of e-Cigarette Substitution: Protocol for Two Living Systematic Reviews
Authors: O'Leary Renee , Qureshi Maria Ahmed , La Rosa Giusy Rita Maria , Vernooij Robin W M , Odimegwu Damian Chukwu , Bertino Gaetano , Polosa Riccardo
Published: May 2021

Background

Despite the clear risks of tobacco use, millions of people continue to smoke. Electronic nicotine delivery systems (ENDS), commonly called e-cigarettes, have been proposed as a substitute for those who are unwilling or unable to quit. Current systematic and narrative reviews on the health effects of ENDS use, particularly respiratory and cardiovascular effects, have come to differing conclusions.

Objective

We conducted two systematic reviews to critically assess and synthesize available human studies on the respiratory and cardiovascular health effects of ENDS substitution for people who smoke. The primary goal is to provide clinicians with evidence on the health effects of ENDS substitution to inform their treatment recommendations and plans. The twin goal of the reviews is to promote health literacy in ENDS users with facts on the health effects of ENDS.

Methods

These two reviews will be living systematic reviews. The systematic reviews will be initiated through a baseline review. Studies will be evaluated using the JBI quality assessment tools and a checklist of biases drawn from the Centre for Evidence Based Medicine Catalogue of Bias. A narrative synthesis is planned because of the heterogeneity of data. A search for recently published studies will be conducted every 3 months, and an updated review will be published every 6 months for the duration of the project or possibly longer.

Results

The baseline and updated reviews will be published in a peer-reviewed journal. The findings of the reviews will be reported in a white paper for clinicians and a fact sheet for people who use ENDS.

Conclusions

The substitution of ENDS for cigarettes is one way to potentially reduce the risks of smoking. Clinicians and their patients need to understand the potential benefits and possible risks of substituting ENDS for cigarettes. Our living systematic reviews seek to highlight the best and most up-to-date evidence in this highly contentious and fast-moving field of research.

Trial Registration

PROSPERO CRD42021239094; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=239094

International Registered Report Identifier (IRRID)

DERR1-10.2196/29084
Health Information Seeking Behaviors on Social Media During the COVID-19 Pandemic Among American Social Networking Site Users: Survey Study
Authors: Neely Stephen , Eldredge Christina , Sanders Ron
Published: May 2021

Background

In recent years, medical journals have emphasized the increasingly critical role that social media plays in the dissemination of public health information and disease prevention guidelines. However, platforms such as Facebook and Twitter continue to pose unique challenges for clinical health care providers and public health officials alike. In order to effectively communicate during public health emergencies, such as the COVID-19 pandemic, it is increasingly critical for health care providers and public health officials to understand how patients gather health-related information on the internet and adjudicate the merits of such information.

Objective

With that goal in mind, we conducted a survey of 1003 US-based adults to better understand how health consumers have used social media to learn and stay informed about the COVID-19 pandemic, the extent to which they have relied on credible scientific information sources, and how they have gone about fact-checking pandemic-related information.

Methods

A web-based survey was conducted with a sample that was purchased through an industry-leading market research provider. The results were reported with a 95% confidence level and a margin of error of 3. Participants included 1003 US-based adults (aged ≥18 years). Participants were selected via a stratified quota sampling approach to ensure that the sample was representative of the US population. Balanced quotas were determined (by region of the country) for gender, age, race, and ethnicity.

Results

The results showed a heavy reliance on social media during the COVID-19 pandemic; more than three-quarters of respondents (762/1003, 76%) reported that they have relied on social media at least “a little,” and 59.2% (594/1003) of respondents indicated that they read information about COVID-19 on social media at least once per week. According to the findings, most social media users (638/1003, 63.6%) were unlikely to fact-check what they see on the internet with a health professional, despite the high levels of mistrust in the accuracy of COVID-19–related information on social media. We also found a greater likelihood of undergoing vaccination among those following more credible scientific sources on social media during the pandemic (χ216=50.790; φ=0.258; P<.001).

Conclusions

The findings suggest that health professionals will need to be both strategic and proactive when engaging with health consumers on social media if they hope to counteract the deleterious effects of misinformation and disinformation. Effective training, institutional support, and proactive collaboration can help health professionals adapt to the evolving patterns of health information seeking.
Correctional protege mentorship as an effort of resocialization in class II special correctional institution for children of Kendari
Authors: Arifai Arifai , Zainuddin Zainuddin
Published: May 2021

Mentorship for correctional proteges is basically an effort to re-socialize proteges when they return to society. The research constructs how the implementation of the correctional protege mentorship system so that correctional protege can be well received by the community. This research is empirical and is descriptive. The research finding shows that the mentoring carried out by LPKA Class II Kendari is personality mentorship which includes religious mentoring in the form of congregational prayer guidance, religious lecture (kultum), and reading and writing of the Koran. Mentoring legal awareness in the form of legal education. Skills mentorship in the form of making hydroponics, making chairs from aqua bottles and trash, and making handicrafts such as ashtrays and bracelets. The implementation of mentorship at LPKA Class II of Kendari has not been optimally carried out. This will have an adverse impact on correctional protege when they reintegrate with communities that are still giving them a negative stigma.
EVALUASI PENAMBAHAN JUMLAH LANTAI PADA GEDUNG PERKULIAHAN FAKULTAS TEKNIK UNIVERSITAS JEMBER
Authors: Subagio Hari , Krisnamurti  , Paksitya Purnama Putra
Published: May 2021

Sarana pembelajaran untuk mahasiswa Fakultas Teknik Universitas Jember masih kurang tercukupi. Lima belas program studi pada Fakultas Teknik UNEJ hanya dilayani dalam satu gedung perkuliahan. Salah satu solusi untuk permasalahan tersebut ialah dengan menambahkan jumlah lantai pada gedung eksisting untuk memperbanyak jumlah ruang kelas. Penambahan dilakukan sejumlah 3 lantai sebagai ruang kelas dan 1 lantai atap sebagai ruang pertemuan (rooftop). Perencanaan dan evaluasi dilakukan dengan memodelkan gedung secara 3D pada sebuah program analisis struktur. Analisis dan evaluasi pada program analisis struktur dimodelkan dengan dimensi yang sama dengan kondisi eksisting dan akan dilakukan penambahan jumlah lantai dengan dimensi sesuai perhitungan preliminari desain. Hasil pemodelan menujukkan kondisi gedung rencana masih aman. Nilai simpangan antar lantai terbesar adalah 10.2 mm yang masih di bawah simpangan ijin (31.5 mm), dan nilai integritas struktur sebesar -0.97 (syarat -1 < - 0.97 < 1).
PERENCANAAN BANGUNAN JETTY DARI BAHAN BRONJONG DI MUARA SUNGAI SUNGGA PANTAI JASRI KABUPATEN KARANGASEM
Authors: Putu Gede Panji Oka Chandra  , Cok Agung Yujana  , I Ketut Yasa Bagiarta
Published: May 2021

Pantai Jasri telah memiliki bangunan pantai berupa revetment yang juga berfungsi untuk menahan terjadinya limpasan gelombang. Pasang surut dan debit sungai di muara Sungai Sungga Pantai Jasri berpengaruh terhadap penyebaran sedimen yang melayang dikolom air dan saat tertentu dapat mengendap di dasar perairan. Dengan demikian, perencanaan jetty pada mulut muara bertujuan untuk menahan sedimen sejajar pantai yang terdorong oleh gelombang, masuk ke muara dan kemudian mengendap yang dapat menyebabkan terjadinya banjir di mulut muara. Berdasarkan analisis perencanaan bangunan jetty di muara Sungai Sungga dengan menggunakan material bronjong diperoleh: tinggi bangunan jetty (Eljetty) = 3 m, berat batu lapis pertama (W1) = 2.486 ton, berat batu lapis kedua (W2) = 0.2486 ton, lebar puncak (B) = 2.434 m, tebal lapis pertama (t1) = 2.434 m, tebal lapis kedua (t2) = 1.129 m, tebal pelindung kaki (ttoe) = 1.781 m, lebar pelindung kaki (Btoe) = 2.166 m, berat batu pelindung kaki (Wtoe) = 0.148 ton, dan perkiraan biaya pembangunannya sebesar Rp.4,106,578,000.00.
Pengaruh Dana Pihak Ketiga, BI Rate dan Inflasi Terhadap Penyaluran Kredit Pada PT. Bank Mandiri, Periode 2014(I) -2018(IV)
Authors: Naro Vania Maria Sarmento , Purnami Anak Agung Sri , Wulandari I Gusti Ayu Athina
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh dana pihak ketiga (DPK), BI Rate dan inflasi terhadap penyaluran kredit pada Bank Mandiri. Pengumpulan data diperoleh dengan cara mengumpulkan data yang dipublikasikan oleh Otoritas Jasa Keuangan, Bank Indonesia dan Bank Mandiri. Penelitian ini menggunakan data time series dan dianalisis menggunakan teknik analisis regresi linier berganda yaitu untuk mengetahui pengaruh dari variabel bebas terhadap variabel terikat dengan menggunakan uji hipotesis yaitu uji serempak (F test) dan Uji parsial (t test). Hasil uji F menunjukkan bahwa variabel dana pihak ketiga, BI Rate dan inflasi berpengaruh signifikan terhadap penyaluran kredit pada PT. Bank Mandiri, dengan tingkat signifikansi (0,000<0,05). Hasil uji t menunjukkan bahwa secara parsial Dana Pihak Ketiga (DPK) berpengaruh positif dan signifikan dengan tingkat signifikansi (0,000<0,05), BI Rate berpengaruh positif dan tidak signifikan dengan tingkat signifikansi (0,395>0,05) dan Inflasi berpengaruh negatif dan tidak signifikan dengan tingkat signifikansi (0,059>0,05) terhadap penyaluran kredit pada Bank Mandiri.
“Por Instagram y todos los días”: Repertorios informativos de estudiantes universitarios del centro de Argentina
Authors: Tarullo Raquel
Published: May 2021

Este artículo expone algunos hallazgos de una investigación interdisciplinar sobre repertorios informativos de jóvenes universitarios del centro de Argentina. Con una metodología mixta, que combinó datos cuantitativos recogidos mediante un cuestionario digital (n=491) y datos cualitativos obtenidos en entrevistas semiestructuradas (n=72), los resultados revelan el protagonismo de Instagram como fuente de noticias y la relevancia que este grupo le otorga a la información local que circula en redes de contactos cercanos. Además, el encuentro incidental con las noticias ocurre no solo en espacios digitales, sino que forma parte de las rutinas informativas familiares, donde los medios tradicionales siguen ocupando un lugar destacado. Asimismo, el interés individual incide en activar una nueva fase de hábitos informativos que conduce a la profundización en el consumo de contenidos cercanos a sus motivaciones. Estos hallazgos subrayan la necesidad de instrumentar instancias de alfabetización informacional en la universidad.
Biological characteristics of Trichogramma pretiosum Riley, 1879 (Hymenoptera: Trichogrammatidae) under temperature stress by successive generations
Authors: De Araujo Junior Luis Moreira , Zago Hugo Bolsoni , Damascena Alixelhe Pacheco , Faria Luana Viana , Pereira Aléxia Gonçalves , Madalon Fernando Zanotti , De Carvalho José Romário , Pratissoli Dirceu
Published: May 2021

The objective of this study was to evaluate the biological characteristics of Trichogramma pretiosum (Riley 1879) under room temperature and temperature stress by successive generations. The evaluation was carried out in split-plot in the time. The temperature (25 ºC – room temperature and 33 ºC – temperature stress) was the Factor 1 and the Generations (n = 15) were the Factor 2. The biological characteristics evaluated were: longevity; posterior tibia length; number of parasitized eggs; emergence; egg-adult period; sexual ratio and deformed individuals. The increase in temperature, from the first generations of T pretiosum, caused an influence in all observed variables. However, for the emergence and sex ratio variables, there was no significant difference between heat stress and control (room temperature) as of the 14th generation, which suggests an adaptability of the species. This adaptability may imply obtaining more aggressive natural enemies in relation to their host (insect pest) and consequently in the greater efficiency of biological control.
Physicochemical evaluation of oil blends of Glycine max L., Helianthus annus L. and Cocos nucifera L. under thermoxidation
Authors: Pinheiro Andressa Alves , Jorge Neuza
Published: May 2021

The predominance of mono and polyunsaturated fatty acid of Glycine max L. (soybean) and Helianthus annus L. (sunflower) oils make them more unstable under high temperatures and susceptible to oxidation. On the other hand, the composition of the Cocos nucifera L. (coconut) oil is predominantly saturated and has high oxidative stability. The formulation of oil blends allows some improvements in their nutritional and physicochemical characteristics. Thus, the aim of this work is to evaluate the G. max oil (SB), H. annus oil (SF), C. nucifera oil (C) and the blends G. max:C. nucifera (SB:C, 75:25 v/v) and H. annus:C. nucifera (SF:C, 75:25 v/v) as to their physicochemical properties when under thermoxidation (180 °C/15 h). Before the thermoxidation, the C presented less degradation in relation to the others, while the SF:C was the most efficient in inhibiting oxidation due to the presence of low levels of peroxide values, however, it presented less degradation to ρ-anisidine and conjugated dieneic acids. The SF:C presented higher oxidative stability and less degradation in relation to SB:C. Consequently, the application of these oil blends is recommendable in processes that involve high temperatures, such as frying.
Macroelements versus toxic elements in selected wild edible mushrooms of the Russulacea family from Serbia
Authors: Dimitrijevic Marija , Mitic Violeta , Djordjevic Dragan , Popovic Gordana , Krstic Nenad , Nikolic Jelena , Stankov-Jovanovic Vesna
Published: May 2021

Three edible mushrooms of the Russulacea family (Lactarius deliciosus, Lactarius sanguifluus and Lactarius semisanguifluus), most frequently consumed in Serbia, were analyzed using the ICP-OES technique to evaluate the content of K, P, Ca, Mg, Na, Al, As, Cd and Pb, both in cap and stipe. Corresponding soils were analyzed, too. Based on the obtained values for the elemental composition of the mushrooms and the soil, bioaccumulation and translocation factors were calculated. All the examined mushrooms species were recognized as bioexclusors of analyzed toxic elements, but bioaccumulators of K, P and Ca. The studied mushrooms are good sources of macroelements. One portion of 300 g of fresh mushrooms had a significant contribution of K and P, exceeding 15 % of the recommended daily intake for the elements. On the contrary, mushrooms had a low potential to bioaccumulate toxic elements, and presented results indicated the regular consumption of wild edible mushrooms is safe for human health. Correlation analysis was applied to determine phosphorus?s influence on the elements? content in the mushrooms and corresponding soils, demonstrating the most remarkable mushrooms' tendency to accumulate phosphorus.
Keynes: The second coming?
Authors: Skidelsky Robert
Published: May 2021

This article outlines principles of a modernised macroeconomic framework,
drawing on John Maynard Keynes. It explores the historical context in which
Keynes? economic theory arose, and the history of its application and
subsequent replacement by neoclassical economics. The article argues that
any updated Keynesian programme must address three new problems:
globalization, wealth inequality and climate change. It sketches out the
ways in which these might be addressed.
Gingival biotype - comparative analysis of different evaluation methods
Authors: Djordjevic Filip , Dubovina Dejan , Bubalo Marija , Radosavljevic Rasa , Bukumiric Zoran
Published: May 2021

Background/Aim. Gingival biotype can have a significant impact on the outcome of the periodontal therapeutic procedures and the predictability of their aesthetic outcome. There is a strong correlation between the types of biotype and the potential gingival recession after restorative, periodontal, and implant surgical procedures. Therefore, accurate identification of gingival biotypes before initiating these procedures is one of the significant predictive factors for their success. The aim of this study was to evaluate the reliability of accurate gingival biotype determination with the use of the visual method, periodontal, and trans-gingival probing compared to the direct measurement method. Methods. This prospective study involved 33 patients indicated for apical root resection in the intercanine sector of the upper jaw. Gingival biotype identification was performed in all patients using the following techniques: 1) visual method; 2) periodontal probe technique; 3) trans-gingival probing; and 4) direct measurement after flap elevation. Statistical analysis of the obtained data was performed to assess the diagnostic accuracy of the visual method, periodontal probing method, and trans-gingival probing method in relation to the direct measurement method, used as a gold standard, to discriminate the gingival thickness biotype (thin versus thick). Results. The overall accuracy of the tested diagnostic procedures compared to direct gingival biotype measurement was 66.7% for the visual method, 78.8% for periodontal probing, and 97.0% for trans-mucosal probing. Conclusion. The periodontal probing method can be recommended for gingival biotype determination as a routine method since its sensitivity and overall accuracy are higher compared to the visual method. The trans-gingival method, in terms of sensitivity and comprehensive accuracy, almost completely coincides with the direct method, but it is more invasive compared to the periodontal probing method, and it has to be conducted in local anesthesia.
Medicine in the Hippocratic and post-Hippocratic age
Authors: Lazarevic Tatjana , Kovacevic Zoran , Janicijevic-Petrovic Mirjana , Ljujic Biljana , Glisic Milos , Janicijevic Katarina
Published: May 2021

nema
Nursing students’ experience of academic learning in a Cambodian School of Nursing
Authors: Ryan Andrea
Published: May 2021

The purpose of the study was to determine nursing students’ satisfaction of their experiences of their academic program at a university nursing school in Cambodia. Positive experiences of educational programs have been linked to the increased development of a professional identity and beliefs around the chosen discipline. As nursing education and the nursing profession continues to undergo rapid development and change in Cambodia, it was seen that an evaluation of both the teaching quality and nursing students’ experience within a program of study was an important aspect of maintaining high quality nursing education programs. The study is a cross-sectional design using the Undergraduate Nursing Students` Academic Satisfaction Scale (UNSASS) in addition to demographic data. The UNSASS, with permission from the authors, underwent a cross-cultural adaptation for the Cambodian context. Analysis was undertaken using SPSS version 17.0. One hundred and seventy Associate Degree and Bachelor of Science in Nursing students were surveyed, including students in their middle and final years of study from both cohorts. The findings show that overall students felt positively about their education experience, felt safe to make mistakes in a supportive environment, and had positive relationships with the faculty and clinical preceptors. However, the large number of neutral responses may indicate a cultural hesitance in reporting any negative feedback.
SOSIALISASI PEMELIHARAAN PERSONAL HYGIENE DAN PROTEKSI DIRI DI LINGKUNGAN PERUMAHAN PADA ERA NEW NORMAL
Authors: Karlina Nina , Rusli Budiman , Muhtar Entang Adhi , Candradewini Candradewini
Published: May 2021

Perumahan merupakan kelompok rumah yang memiliki fungsi sebagai lingkungan tempat tinggal maupun hunian yang memiliki berbagai prasarana lingkungan seperti kelengkapan dasar meliputi penyediaan air minum, pembuangan sampah, listrik, telepon, jalan serta sarana lingkungan yang merupakan sarana penunjang yang berfungsi untuk penyelenggaraan serta pengembangan kehidupan.  Pada masa pandemi Covid-19 ini dituntut untuk menjaga diri dan lingkungan agar dapat menanggulangi penyebaran Covid-19. Salah satu dengan melakukan penataan kawasan pemukiman dan perumahan. Pada era new normal ini sangatlah penting karena banyak masyarakat berpersepsi bahwa new normal ini kembali ke situasi biasa sebelum adanya pandemi ini. Akan tetapi penyebaran Covid-19 masih cukup tinggi per harinya yaitu sekitar 3000 kasus baru terjadi di Indonesia. Dalam menanggulangi penyebaran virus corona yaitu mematuhi protokol kesehatan dalam beraktivitas sehari–hari misalnya penggunaan masker, menjaga jarak, hindari kerumunan serta selalu mencuci tangan. Hal tersebut dapat dikatakan sebagai cara personal hygiene dan proteksi diri yang sangat penting, apabila masyarakat sudah dapat mematuhi protokol kesehatan untuk memelihara personal hygiene dan proteksi diri maka bisa mengurangi penyebaran virus corona di lingkungan tempat tinggal seperti pemukiman dan perumahan. Harus adanya kesadaran dari masing-masing warga menciptakan lingkungan perumahan tempat tinggalnya terbebas dari penyebaran virus corona.
PENINGKATAN PENGETAHUAN MENGENAI PENTINGNYA MENJAGA KADAR HEMOGLOBIN DI DALAM DARAH PADA SISWI SMA NEGRI 1 GARUT
Authors: Sumarna Umar , Nurhakim Furkon , Rosidin Udin
Published: May 2021

ABSTRAKSiswa-siswi sekolah menengah terdiri dari anak-anak remaja calon penerus bangsa, dimana fisik dan intelektualnya sedang berkembang, serta dipersiapkan untuk menyongsong masa depan yang lebih baik. Oleh karena itu sangat disayangkan bila status kesehatannya rendah, tubuhnya lemah, dan kurang produktif. Kondisi tersebut akan terjadi bila kadar haemoglobin dalam darahnya rendah. Pada studi pendahuluan yang dilakukan di SMA Negeri 1 Garut ditemukan bahwa dalam pemeriksaan di laboratorium, banyak siswa-siswinya yang terbukti kadar haemoglobinnya rendah, yaitu di bawah 11 gr%, terutama para siswinya. Data tersebut diperkuat dengan banyaknya para siswi yang dibopong ke ruang UKS setelah melakukan aktivitas yang agak berat, seperti olahraga, upacara, kegiatan pramuka dan lain lain. Upaya untuk mengatasi hal itu telah dilakukan oleh pihak sekolah dengan cara bekerja sama dengan pihak puskesmas setempat dengan menyelenggarakan kegiatan UKS. Adapun program yang nyata dan spesifik pada siswi di SMA Negeri 1 Garut adalah program pemberian tablet Fe. Masalah yang terdapat di sekolah tersebut adalah pada kurang berhasilnya program pemberian tablet Fe dalam upaya menjaga kadar haemoglobin dalam darah. Hal ini terjadi karena kurangnya disiplin para siswi dalam melaksanakan program tersebut, dimana tablet Fe tersebut banyak yang dibuang bukan dimakan dengan alasan yang bermacam-macam. Metode yang digunakan adalah ceramah, diskusi dan demonstrasi. Hasil yang didapatkan menunjukkan, bahwa responden siswi SMA Negeri 1 Garut sebanyak 71 orang memperoleh nilai pretest 4,55 s.d 90,91 dan nilai postes 45,45 s.d 100,00, sementara nilai rerata pretes 36,36, dan nilai rerata postest 68,16 dengan nilai signifikansi 0,00. Maka dapat disimpulkan bahwa para siswi SMA Negeri 1 Garut sangat antusias dalam mengikuti pendidikan kesehatan yang berkaitan dengan peningkatan kadar haemoglobin dalam darah. Kata Kunci: haemoglobin, siswi, tablet Fe