bluuebunny/crossref_metadata_2025 huggingface dataset:
Owning a Samoyed dog – cost analysis
Authors:   Department of Animal Anatomy and Zoology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University in Szczecin, Janickiego Str. 33, 71-270 Szczecin, Królaczyk Katarzyna , Kavetska Katarzyna Marta ,   Department of Animal Anatomy and Zoology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University in Szczecin, Janickiego Str. 33, 71-270 Szczecin, Flis Katarzyna ,   Department of Animal Anatomy and Zoology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University in Szczecin, Janickiego Str. 33, 71-270 Szczecin
Published: March 2022

The aim of this study was to evaluate the effects and expenditures related to maintenance of Samoyed dogs, specifying the contribution of individual factors affecting the overall economic account. The research material consisted of data obtained from surveys conducted among 111 owners of Samoyeds kept in Poland. The survey asked questions about the costs associated with owning a dog. The results were compiled with the minimum, maximum and average costs, and distinguished the percentage share of individual annual costs. The obtained results were the basis for the conclusion that owners of male dogs incur higher annual costs than owners of bitches. The largest share in the annual costs was related to feeding, and in one-off costs it was the purchase of an animal. In addition to the financial aspects of having a dog, also taken into account should be the effects and non-measurable costs associated with it. It seems that awareness of the costly nature of owning a pure-bred dog can increase the responsibility and reduce the number of abandoned dogs.
Daftar Isi JPI Vol. 5 No. 1
Authors: Kunto Imbar
Published: March 2022

DAFTAR ISI                Volume 5, Nomor 1, Maret 2022.

 

Nur Rahmi, W. (2022). Penerapan Model Pembelajaran Assure Berbasis Daring/E-Learning pada Mata Kuliah Bahasa Inggris di Sekolah Tinggi Teknologi Sinar Husni. Jurnal Pembelajaran Inovatif, 5(1), 01 - 07. https://doi.org/10.21009/JPI.051.01

 

Ramadhan, M. A., Anisah, A., & Darmawan, O. D. (2022). Pengembangan E-Modul Berbasis Bim Autodesk Infraworks Pada Mata Pelajaran Konstruksi Jalan Dan Jembatan Di SMKN 1 Cikarang Barat. Jurnal Pembelajaran Inovatif, 5(1), 08 - 23. https://doi.org/10.21009/JPI.051.02

 

Kirana, P., Chaeruman, U. A., & Nursetyo, K. I. (2022). Pengembangan "Supermath" sebagai Multimedia Pembelajaran Berbasis Gamifikasi untuk Matematika Kelas 2. Jurnal Pembelajaran Inovatif, 5(1), 24 - 29. https://doi.org/10.21009/JPI.051.03

 

Wahyu, U. A., Widyaningrum, R., & Ariani, D. (2022). Pengembangan Job Aid Remote Working untuk Peserta Magang Desain Grafis di Campaign.com. Jurnal Pembelajaran Inovatif, 5(1), 30 - 40. https://doi.org/10.21009/JPI.051.04

 

Ariani, D., Prawiradilaga, D. s., & Fatharani, W. (2022). Inovasi Gamifikasi Pada Pembelajaran Matakuliah Pengembangan Media Sederhana . Jurnal Pembelajaran Inovatif, 5(1), 41 - 48. https://doi.org/10.21009/JPI.051.05

 

Ahmad Dhenny Bagaskara, A. D. B., & Anindia Putra, I. N. T. (2022). Penerapan Pembelajaran Secara Daring Aplikasi Google Classroom Di SMPTK Galang Kasih. Jurnal Pembelajaran Inovatif, 5(1), 49 - 55. https://doi.org/10.21009/JPI.051.06

 

Pratiwi, M. E., Imbar, K., & Prawiradilaga, D. S. (2022). Pemanfaatan Prinsip Personalisasi Belajar dalam Pembelajaran Daring pada Mata Kuliah Designing E- Learning. Jurnal Pembelajaran Inovatif, 5(1), 56 - 62. https://doi.org/10.21009/JPI.051.07

 

Dian Rosdiana Noor, Siregar, E., & Chaeruman, U. A. (2022). Pengembangan Mobile Learning dengan Metode Studi Kasus untuk Mata Pelajaran PPKn Kelas VI di SDN Telajung 01. Jurnal Pembelajaran Inovatif, 5(1), 63 - 70. https://doi.org/10.21009/JPI.051.08

 

Khalidah, H., Mulyadi, & Ariani, D. (2022). Media Pembelajaran Permainan Papan Untuk Pendidikan Seksualitas di Lembaga DIAR. Jurnal Pembelajaran Inovatif, 5(1), 71 - 79. https://doi.org/10.21009/JPI.051.09

 

Muhammad Rafik, Vini Putri Febrianti, Afifah Nurhasanah, & Siti Nurdianti Muhajir. (2022). Telaah Literatur: Pengaruh Model Pembelajaran Project Based Learning (PjBL) terhadap Kreativitas Siswa Guna Mendukung Pembelajaran Abad 21. Jurnal Pembelajaran Inovatif, 5(1), 80 - 85. https://doi.org/10.21009/JPI.051.10
Pengembangan "Supermath" sebagai Multimedia Pembelajaran Berbasis Gamifikasi untuk Matematika Kelas 2
Authors: Kirana Putri , Chaeruman Uwes Anis , Nursetyo Kunto Imbar
Published: March 2022

Penelitian pengembangan ini bertujuan untuk menghasilkan produk bernama “Supermath” berupa multimedia pembelajaran berbasis gamifikasi untuk mata pelajaran matematika kelas 2 sekolah dasar. Model pengembangan yang digunakan dalam penelitian ini adalah model pengembangan Rapid Prototyping oleh Tripp dan Bichelmeyer. Evaluasi pada pengembangan ini dilakukan melalui expert review dan one-to-one evaluation yang melibatkan 2 ahli materi, 1 ahli desain pembelajaran, 1 ahli media, dan 3 pengguna. Nilai rata-rata yang diperoleh dari ahli materi adalah 3,85 (sangat baik), sedangkan dari ahli desain pembelajaran memperoleh 3,94 (sangat baik), dan dari ahli media memperoleh 3,58 (sangat baik). Pada tahap one-to-one evaluation, nilai rata-rata yang diperoleh adalah 3,8 (sangat baik). Berdasarkan hasil penilaian tersebut, maka produk “Supermath” yang telah dikembangkan dianggap sangat baik dan layak untuk digunakan sebagai media penunjang pembelajaran.
Pengembangan Job Aid Remote Working untuk Peserta Magang Desain Grafis di Campaign.com
Authors: Wahyu Uli Afrilia , Widyaningrum Retno , Ariani Diana
Published: March 2022

Penelitian pengembangan yang berjudul “Pengembangan Job Aid Remote Working Untuk Peserta Magang Desain Grafis Di Campaign.com” bertujuan untuk menghasilkan job aid sebagai alat bantu kerja untuk memfasilitasi dan meminimalisir kesalahan-kesalahan peserta magang desain grafis dalam kerja jarak jauh (remote work). Model yang digunakan yaitu model pengembangan job aid oleh Charlotte Long. Hasil penelitian berupa job aid digital dengan format PDF Interaktif. Responden yang terlibat untuk evaluasi produk diantaranya, ahli materi, ahli media dan pengguna produk. Nilai yang didapat pada tahap evaluasi formatif oleh ahli materi adalah 3,7 yang termasuk kategori sangat baik, ahli media adalah 3,75 yang termasuk kategori sangat baik, dan pengguna produk (peserta magang desain grafis) adalah 3,93 yang termasuk kategori sangat baik. Hasil penilaian ini digunakan untuk meningkatkan kualitas produk yang dihasilkan. Hasil penelitian ini sebagai intervensi untuk memfasilitasi belajar dan solusi masalah kinerja peserta magang desain grafis yang bekerja jarak jauh (remote work) di Campaign.com.
ANALISA KOMPUTASI ALGORITMA DES DENGAN RC4 UNTUK KEAMANAN DATA
Authors: Busran  , Jeri Widodo Putra
Published: March 2022

Keamanan dan kerahasiaan data merupakan salah satu aspek terpenting dalam bidang komunikasi khususnya komunikasi yang menggunakan media komputer. Salah satu bidang ilmu pengetahuan yang digunakan untuk mengamankan data adalah kriptografi, kecepatan proses kriptografi dalam implementasinya sering menjadi hal yang penting diperhatikan. Penelitian bertujuan untuk mengetahui kecepatan waktu yang diperlukan dalam melakukan proses enkripsi dan dekripsi data antara dua algoritma yaitu algoritma RC4 dengan algoritma DES. Dari penelitian yang dilakukan menggunakan data berformat pdf, jpg, mp3 dimana ukuran data dari yang terkecil yaitu 1000kb sampai ukuran data yang terbesar 20mb yang dimasing - masing dilakukan pengujian sebanyak lima kali pengujian dan dihasilkan dari data yang ukuran terkecil dari algoritma RC4 dihasilkan waktu selama 0,23288/s dan data yang terbesar menghasilkan waktu 0,2529/s dan mengunakan algoritma DES dihasilkan waktu terkecil 0,23508/s dan waktu terbesar 0,2545/s, dari pengujian tersebut dapat diambil kesimpulan bahwa algoritma RC4 lebih cepat dari pada algoritma DES dalam melakukan komputasi data.

 

Data security and confidentiality is one of the most important aspects in the field of communication, especially communication using computer media. One of the fields of science that is used to secure data is cryptography, the speed of the cryptographic process in its implementation is often an important thing to pay attention to. This study aims to determine the speed of time required to encrypt and decrypt data between two algorithms, namely the RC4 algorithm and the DES algorithm. From research conducted using data in pdf, jpg, mp3 format where the data size from the smallest is 1000kb to the largest data size of 20mb which is each tested five times and the resulting data is the smallest size of the RC4 algorithm resulting in a time of 0 , 23288 / s and the largest data yield 0.2529 / s time and using the DES algorithm the smallest time is 0.23508 / s and the largest time is 0.2545 / s, from these tests it can be concluded that the RC4 algorithm is faster than the algorithm. DES in computing data.
SISTEM INFORMASI OBJEK WISATA PULAU TELLO KABUPATEN NIAS SELATAN BERBASIS WEB
Authors: Fransiskus Manao  , Ilham Tri Maulana  , Monando Rio Meta
Published: March 2022

Saat ini belum tersedia informasi yang cukup memadai tentang objek-objek wisata yang ada di Pulau Tello sehingga belum banyak wisatawan dan juga masyarakat yang mengetahui keberadaan objek-objek wisata yang cukup potensial. Oleh karena itu, perlu diatasi dengan melakukan promosi dan penyediaan informasi dengan menggunakan media informasi berbasis website. Tujuan sistem informasi berbasis web ini adalah untuk mempromosikan objek wisata yang ada di wilayah Pulau Tello. Metodologi penelitian yang dilakukan adalah metode waterfall. Hasil yang diperoleh dari Sistem Informasi Objek Wisata Pulau Tello Kabupaten Nias Selatan Berbasis Web ini adalah informasi letak objek wisata serta data atributnya berupa nama lokasi, alamat, keterangan tentang objek wisata serta tampilan gambar objek wisata. Dengan Sistem Informasi Objek Wisata Pulau Tello Kabupaten Nias Selatan Berbasis Web akan memberikan efisiensi waktu dan kecepatan dalam mempromosikan objek wisata, masyarakat dan wisatawan tidak lagi datang ke objek wisata untuk mendapatkan informasi objek wisata Pulau Tello.

 

Currently there is not enough information about tourist object on Tello Island so that not many tourist and also the public are aware of the existence of tourism object that are quite potential. Therefore, this need to be overcome by doing promotion and provision of information using website-based information media. The purpose of this web-based information system is to promote tourism object in the Tello Island area. The research method used waterfall method. The results obtained from Web-Based Information System for Tello Island Tourism Object, South Nias Regency this is information on the location of a tourist attraction as well as the attribute in the form of location name, address, description about a tourist attraction as well as displaying image of tourist attraction. With a Web-Based Information System for Tello Island Tourism Object, South Nias Regency will provide time ef iciency and speed in promoting tourist attraction, the community and tourist not come again to tourist object to get information about Tello Island attraction.
PERANCANGAN APLIKASI SISTEM MONITORING BEBAN TRAFO BERBASIS ANDROID PADA PT. PLN (PERSERO)
Authors: Mandarani Putri
Published: March 2022

Listrik sudah menjadi kebutuhan yang tidak terpisahkan dari berbagai kegiatan yang dilakukan oleh manusia. PT. PLN terus berupaya memberikan layanan terbaik kepada masyarakat sehingga pasokan energi listrik dapat terpenuhi. Trafo atau transformator dapat dikatakan sebagai jantung transmisi dan distribusi, maka suatu transformator diharapkan dapat beroperasi secara maksimal. Monitoring beban trafo adalah kegiatan memantau status atau kondisi terkini dari trafo. Pemantauan beban trafo di lapangan dengan menggunakan catatan tangan merupakan salah satu kendala yang perlu dioptimalkan. Dengan adanya sistem monitoring yang baik maka ketersediaan akan energi listrik akan selalu terjaga. Aplikasi sistem monitoring berbasis android dirancang sebagai solusi permasalahan tersebut. Aplikasi dapat dioperasikan jika perangkat smartphone yang digunakan terkoneksi ke jaringan internet. Sehingga aplikasi ini dapat meningkatkan efisiensi ruang, waktu dan tenaga kerja. Pada aplikasi ini ada tiga jenis pengguna yaitu user, admin dan operator. User adalah pimpinan PT.PLN(Persero) yang hanya bisa melihat data hasil pengukuran trafo. Operator adalah petugas lapangan yang menggunakan aplikasi ini untuk menginputkan hasil pengukuran trafo. Admin mempunyai wewenang untuk menginputkan data trafo baru dan melakukan edit dan hapus data hasil pengukuran jika diperlukan. Aplikasi Sistem Monitoring Trafo pada PT.PLN(Persero) berbasis android  ini dirancang menggunakan android studio, dengan bahasa pemograman Java, dan basisdata MySQL.
IMPLEMENTASI ALGORITMA BREADTH FIRST SEARCH DAN METODE CERTAITY FACTOR PADA SISTEM PAKAR DIAGNOSA PENYAKIT TANAMAN CABAI
Authors: Yoga Swara Ganda , Minarni  , Mandarani Putri , Anisya  , Wira Trise Putra Dede
Published: March 2022

Abstract

 

The Department of Agriculture, Food Crops and Horticulture, Regency of Lima Puluh Kota recorded a decrease in chili production every year which can cause direct losses to farmers. This is due to the presence of diseases that can reduce the quantity and quality of yields, increase production costs, and reduce the ability of farming businesses. To overcome this problem, the Department of Agriculture, Food Crops and Horticulture has deployed agricultural extension workers (PPL) as communicators for development who are expected to play multiple roles, as teachers, mentors, advisors, information providers and farmer partners. In Fifty Cities District, the number of existing agricultural extension workers is 104 people. They foster 166,157 farmers with an area of 22,282 ha and plantation area of 28,150 ha who are members of more than 1,400 farmer groups spread over 410 jorong, 79 nagari, and 13 sub-districts in Lima Puluh Kota Regency. Because the extension workers are not comparable with the number of regions, the extension process, the performance of the extension workers, and the knowledge that will be conveyed to farmers are not optimal. Therefore, a system was designed, namely an expert system for diagnosing chili plant diseases using the CF (Certainty Factor) method and the BFS (Breadth First Search) algorithm. Which serves to assist the community in conducting consultations without having to meet a disease expert or wait for counseling.

 

Keywords : Expert system, Certainty factor, Breadth fisrt search, Chili plants
SISTEM MONITORING DAN EVALUASI PENERIMA PROGRAM KELUARGA HARAPAN (PKH) UNTUK KELUARGA PENERIMA MANFAAT (KPM) BERBASIS WEB di NAGARI KOTO TINGGI KECAMATAN ENAM LINGKUNG
Authors: Warman Indra , Asrizon Selfen
Published: March 2022

The Effort to accelerate poverty reduction, the Government launched the Program Keluarga Harapan (PKH). This program aims to improve human quality by providing conditional cash assistance for poor families designated as Beneficiary Families in accessing health and education services, reducing the burden of spending, and increasing poor families' income.

In implementing the Program Keluarga Harapan (PKH) it is necessary to monitor and evaluate the activities carried out on the beneficiary families in Nagari Koto Tinggi, Enam Lingkung District. This study aims to create an evaluation monitoring system for PKH beneficiaries. This evaluation monitoring system was built using the Laravel framework, PHP web programming, and DBMS MySQL, the output of a web-based information system for monitoring and evaluating PKH group data, categories, budget realization for Beneficiary Families, and graphic reports including Education, toddlers, pregnant women (health), persons with disabilities and the elderly (social welfare),  the PKH evaluation monitoring system can assist PKH managers in monitoring the evaluation of Beneficiary Families data.
KARAKTERISTIK AGROMORFOLOGI DAN POLA PEWARISAN WARNA PELEPAH DAUN BIBIT KELAPA PADA PERAKITAN VARIETAS KELAPA HIBRIDA TIPE BARU
Authors: Romadhon Muhammad Roiyan , Mahayu Weda Makarti , Miftahorrachman NFn , Maskromo Ismail
Published: March 2022

Tipe kelapa Dalam pada umumnya memiliki pola menyerbuk silang, sedangkan kelapa genjah pada umumnya menyerbuk sendiri. Persilangan Kelapa Genjah x Kelapa Dalam akan mewariskan sifat heterosis pada turunan F1, dan tingkat heterosis tergantung daya gabung kedua tetuanya. Keberhasilan persilangan Genjah x Dalam pada tingkat bibit dapat dilihat dari pelepah daun bibit F1 berdasarkan warna kecambah/pelepah bibit kedua tetuanya. Warna kuning bersifat resesif terhadap warna hijau dan coklat, sedangkan warna merah bersifat dominan terhadap warna hijau dan kuning. Penelitian menggunakan Rancangan Acak Kelompok dengan tiga ulangan. Penelitian  ini bertujuan untuk  memperoleh informasi tentang pola pewarisan beberapa karakter kualitatif pada tanaman kelapa hasil persilangan pada fase bibit. Hasil penelitian menunjukkan bahwa persilangan antara GMM  x DTA, GMM x DBI, dan GMM x DPU menghasilkan anakan 100% berwarna cokelat yang dikendalikan oleh gen RrGg, sedangkan persilangan antara GKM x DTA, GKM x DBI, dan GKM x DPU menghasilkan anakan 100% berwarna hijau (rrGg). Pemilihan tetua betina untuk perakitan hibrida kelapa sebaiknya menggunakan pohon yang berwarna hijau karena akan menghasilkan turunan yang mudah ditelusuri jika terjadi kontaminasi polen.

 
RESPON PERTUMBUHAN VEGETATIF PADI SULUTAN DAN RINDANG 2 DI BAWAH NAUNGAN POHON KELAPA
Authors: Lumban Raja Grace E.Y , Matana Yulianus R. , Butarbutar Regina R. , Ai Nio Song
Published: March 2022

Tanaman padi dapat diintegrasikan dengan tanaman lain dalam rangka mengatasi permasalahan kurangnya ketersediaan beras serta mengoptimalkan produktivitas lahan kosong di perkebunan. Penelitian ini bertujuan untuk mengkaji respon pertumbuhan tanaman padi lokal Sulawesi Utara pada fase vegetatif terhadap naungan kelapa berdasarkan tinggi tanaman, luas daun, biomassa tanaman (berat basah dan berat kering daun, berat basah dan berat kering akar, serta volume akar), dan konsentrasi klorofil. Percobaan faktorial dalam Rancangan Acak Kelompok dilakukan dengan menggunakan dua varietas padi (Sulutan dan Rindang 2), dua perlakuan (ditanam di bawah naungan pohon kelapa dengan jarak tanam pohon kelapa 16 (5 x 3) m (sistem gergaji) dan di area terbuka sebagai kontrol) dengan tiga ulangan. Tinggi tanaman diukur pada hari ke-0 (sebelum perlakuan), 2, 4, 6, 8, 10, dan 14 setelah perlakuan. Luas daun dan biomassa diukur pada hari ke-0 (sebelum perlakuan), 7, dan 14. Konsentrasi klorofil diukur pada hari ke-14 setelah perlakuan. Hasil analisis sidik ragam (ANAVA) pada tingkat kepercayaan 95% menunjukkan adanya perbedaan nyata antara varietas Sulutan dan Rindang 2 untuk tinggi tanaman dan biomassa. Tinggi tanaman varietas Rindang 2 pada hari ke-0, 2, 4, 6, 8, 10, 12 dan 14 lebih besar daripada Sulutan. Berat basah daun, berat kering daun dan berat kering akar varietas Sulutan pada hari ke-0 dan 7 lebih besar daripada Rindang 2. Berat basah akar Sulutan pada hari ke-0 lebih besar daripada Rindang 2. Volume akar varietas Sulutan pada hari ke-7 lebih besar daripada Rindang 2. Pada hari ke-7 dan 14 luas daun varietas Rindang 2 lebih besar daripada Sulutan serta luas daun pada perlakuan naungan lebih besar daripada tanpa naungan. Konsentrasi klorofil daun tidak menunjukkan adanya perbedaan nyata. Di antara respons pertumbuhan yang dievaluasi, luas daun merupakan indikator yang potensial untuk toleransi padi terhadap naungan.
Donor Notification of Permanent Deferral: A Qualitative Study on The Perceptions and Practices of Notifier and Blood Donor in Mexico.
Authors: Serrano-Delgado V Moisés , Valdez-Martínez Edith , Márquez-González Horacio
Published: March 2022

Background.
Informing about permanent deferral requires a process that links the notifier with the donor in a particular way. Little is known about the type of information and how it is disclosed to the donors. The current study aimed to examine perceptions and practices of notifier and blood donor within the framework of the notification process of permanent deferral and from the perspective of the notifier―blood donor relationship.
Methods.
A qualitative study with in-depth interviews. The participants were 13 notifiers and 25 permanently deferred donors. Participants were recruited from a national blood bank and a state’s blood bank. The entire dataset/narratives were analysed using the method of thematic analysis.
Results.
The disclosure of permanent deferral was understood as a matter of disclosing the serological test results and their medical meaning along with a concise explanation of the deferral status with regard to future blood donation and the plan to be followed. The notifiers preferred to act in accordance with the standard protocol despite acknowledging the adverse psychological and social effects to which donors are exposed when they are informed of the possible disease and the consequent permanent deferral. Donors described a variety of psychological and social affectations. They valued honesty in the communication, the clarity of the information provided and a greater involvement of the notifier.
Conclusion.
Even though the notification process does not imply that medical care is being offered to donors, the notifier is the administrator of the well-being of the donor. Notification must not be considered as something apart from care, since it is intimately related to the health of each of the donors and their medical care.
A probabilistic proof for the Syracuse conjecture
Authors: Imad El ghazi
Published: March 2022

We prove the veracity of the Syracuse conjecture by establishingthat from an arbitrary positive integer different from 1 and 4, the Syra-cuse process will never return (after i ≥ 1 steps) to any positive integeralready reached and we conclude using a probabilistic approach.Classification : MSC: 11A25
Longitudinal determinants of anal intercourse among women with, and without HIV in the United States
Authors: Owen Branwen Nia , Baggaley Rebecca , Maheu-Giroux Mathieu , Elmes Jocelyn , Adimora Adaora A , Ramirez Catalina , Edmonds Andrew , Sosanya Kemi , Taylor Tonya T , Plankey Michael , Cederbaum Julie A , Seidman Dominika , Weber Kathleen M , Golub Elizabeth T , Wells Jessica , Bolivar Hector , Konkle-Parker Deborah , Pregartner Gudrun , Boily Marie-Claude
Published: March 2022

Background: Anal intercourse (AI) is not uncommon among U.S. women and, when condomless, confers a far greater likelihood of HIV transmission than condomless vaginal intercourse. We aim to identify determinants preceding AI, among women with, and women without HIV.Methods: 3,708 women living with (73%), and without HIV (27%) participating in the Women’s Interagency HIV Study provided sexual behavior and other data at 6-monthly visits over a median of 9 years (1994–2014). We used generalized estimating equation models to examine sociodemographic, structural and behavioral determinants reported in the visit preceding 1) AI, and 2) condomless AI.Results: AI was reported at least once over follow-up by 31% of women without, and 21% with HIV. AI was commonly condomless; reported at 76% and 51% of visits among women living without HIV, and with HIV, respectively. Women reporting AI were more likely to be younger (continuous variable, adjusted odds ratio (aOR)=0.97, 95% confidence interval (CI):0.96-0.98), Hispanic (aOR=1.88, CI:1.47-2.41) or White (aOR=1.62, CI:1.15-2.30) compared to Black, and have at least high school education (aOR=1.33, CI:1.08-1.65). AI was more likely following the reporting of either (aOR=1.35, CI:1.10-1.62), or both (aOR=1.77, CI:1.13-2.82) physical and sexual violence, excessive drinking (aOR=1.27, CI:1.05-1.66) or any drug use (aOR=1.34, CI:1.09-1.66), multiple male partners (aOR=2.64, CI:2.23-3.11), exchange sex (aOR=3.45, CI:2.53-4.71), one or more female sex partners (aOR=1.32, CI:1.01-1.75), condomless vaginal intercourse (aOR=1.80, CI:1.53-2.09), and high depressive symptoms (aOR=1.23, CI:1.08-1.39). Conclusion: AI disproportionally follows periods of violence victimization, substance use, multiple sex partners and depression. Better prevention messaging and biomedical interventions that reduce acquisition or transmission risk are needed, but when AI occurs in the context of violence against women, as our findings indicate, focusing on gender-based violence reduction and immediate treatment to reduce HIV transmission risk is important.
Near induced transient myopia parameters with mobile use compared to printed text among school children
Authors: Sivaraman Viswanathan , Murali Amirthaa , Hussaindeen Jameel Rizwana , Gopalakrishnan Aparna
Published: March 2022

Background: Hyperopic blur due to temporary myopic shift after sustained near activity due to near induced transient myopia act as a cue for myopia progression. The study aimed at comparing near induced transient myopia parameters after reading with smartphone and print material among children. Method: Children (8-13years) with only refractive error were enrolled into the study. All subjects underwent initial comprehensive eye examination. Pre-task refractive error was measured using Grand Seiko WAM 5500 following a 5-minutes dark adaptation. The subjects were then asked to read a text equivalent to N8 text size at 20 cm on mobile phone for 5 minutes. Immediately after reading, the subject’s post-task distance refractive error was measured for 2 minutes. The procedure was repeated with print reading material. Result:Total of 13 myopes and 13 emmetropes were enrolled. The average NITM magnitude after mobile and print reading for myopes was 0.16 D and 0.20 D respectively. Emmetropes showed a hyperopic shift of 0.11 D and 0.05 D after mobile and print reading respectively. Analysis of variance revealed a statistically significant difference in NITM magnitude between myopes and emmetropes with mobile (F(1)=99.660;p<0.001) and print (F(1)=102.206;p<0.001) usage. Decay time was less after reading with print material when compared to reading with mobile which was statistically significant (Z=-3.18;p=0.01). Conclusion:Longer dissipation time was noted after reading with mobile when compared to reading a print text. Given the additive nature of NITM, long hours of near work with mobile phone could pose a greater risk of myopia progression.
Cardiac magnetic resonance imaging assessment of ventricular mass: a prospective randomized study of the effect of icodextrin-based solution
Authors: Cordeiro Lilian , Ishikawa Walther Yoshiharu , Andreoli Maria Claudia C. , Canziani Maria Eugenia F , Araujo Luiza Karla R P , Pereira Benedito J , Abensur Hugo , Moysés Rosa M. A. , Elias Rosilene M.
Published: March 2022

Background: Left ventricular hypertrophy (LVH) is a risk factor for cardiovascular mortality in patients on peritoneal dialysis (PD). Icodextrin has a greater ultrafiltration power and could improve left ventricular mass by treating fluid overload. Findings from cardiac magnetic resonance imaging (MRI), however, are scarce. Methods: This is a randomized cohort that included prevalent patients on PD recruited from 2 tertiary hospitals. Patients were allocated to the glucose (GLU) or icodextrin (ICO) group. Clinical, demographic, biochemical, bioimpedance (extracellular water/total body water ratio – AEC/ACT) data, and cardiac MRI were evaluated at baseline and after 6 months. The outcome was a change in left ventricular mass adjusted by surface area (ΔLVMI). Results: 22 completed the study (GLU, N=12 and ICO, N=10). Patients from GLU and ICO groups had similar age, sex, underlying disease, and time on dialysis. At baseline, LVH was found in 17 patients (77.3%), with no difference between groups (p=0.748). According to ECW/TBW, 36.8% and 80% of patients from GLU and ICO groups, respectively, were considered hypervolemic (p=0.044). During follow-up, ΔLVMI was 3.9 (-10.7, 2.2)g/m in GLU and 5.2 (-26.8, 16.8) in ICO group (p=0.651). ΔLVMI correlated with change in ΔBNP (r=0.566, p=0.044), and remained significant in a multiple regression analysis. Conclusion: We found no superiority of icodextrin to glucose-based solution in improving LMVI in prevalent patients on PD. Whether icodextrin would improve LVMI in long-term follow-up deserver further evaluation.
Group Homophily as a Measure of Self-Liking of Communities: Application in Vocational Networks
Authors: Wang Fan , Smolyak Alex , Dong Gaogao , Tian Lixin , Havlin Shlomo , Sela Alon
Published: March 2022

Homophily is an important social tendency that has a profound impact on the formation of social connections and the diffusion of information between individuals physically or online.
In analogy to the known sociological concept of homophily, we propose a new complex networks concept named Group Homophily, that measures the preference of an entire group of nodes to interact with members of its own type, rather than with members of other groups (self-liking).
The proposed Group Homophily framework is based on entropy considerations and is a general concept that could be useful in many different types of complex networks where nodes are not homogeneous but rather belong to different classes.
We demonstrate the usefulness of Group Homophily on a vocational
network where workers change jobs between companies. A network is constructed from the career paths (CV) of over 2:1 million workers, that move ∼ 8 million times between ∼ 2:5 million companies during two decades. In this network, companies are categorised by two methods: (1) their industrial sectors which is based upon their business occupation. (2) Companies are also categorised by their interactions with other companies through their exchange of workers and the community classes that this workers’ exchanges forms. Group Homophily estimates the entropy in the fit between these two classification methods. We find for example, that the Healthcare and Energy sectors followed by
Financial and IT sectors, are sectors with high Group Homophily, i.e. have stronger self-liking for workers with previous experience in their own sector. In contrast, Industrials is a sector that show weaker self-liking and can easily exchange workers that have no previous experience in its own sector.
Although the Energy sector has high levels of Group Homophily, we find that this is mainly true for educated individuals. In the Healthcare sector in contrast, this preference is true for both high and low educated individuals. Also, we find that managers generally face lower levels of group homophily
and can therefore change their sectors of occupation with greater ease compared to non-managers.
While we demonstrate the framework of Group Homophily in the context of vocational networks where workers change jobs between companies, Group Homophily is a very general measure that
can be practically applied in almost any type of complex network. For example, it can measure the self-liking (disciplinary versus interdisciplinary) levels of different scientific domains, or to measure the tendencies of scientific collaboration in different countries or universities. It is a general new measure that estimates the self-liking between groups of nodes in a network with heterogeneous
nodes types.
Whole Genome Sequencing and Analysis of Fenvalerate Degrading Bacteria Citrobacter freundii CD-9
Authors: Zhou Xuerui , Lei Dan , Tang Jie , Wu Min , Ye Hong , Zhang Qing
Published: March 2022

Citrobacter freundii CD-9 is a gram-negative bacteria sourced from factory sludge that can use fenvalerate as its sole carbon source and has a broad degradation spectrum for pyrethroid pesticides. The whole genome of CD-9 sequenced using Illumina HiSeq PE150 was reported in this study. The CD-9 genome size was 5.33 Mb and the G + C content was 51.55%. A total of 5,291 coding genes, 9 5s- rRNA, and 79 tRNA were predicted bioinformatically. 3586 genes annotated to the Kyoto Encyclopedia of Genes and Genomes (KEGG) database that can be involved in 173 metabolic pathways, including various microbial metabolic pathways that degrade exogenous chemicals, especially those that degrade aromatic compounds, and also produce a variety of bioactive substances. Fifty genes related to pyrethroid degradation were identified in the C. freundii CD-9 genome, including 9 dioxygenase, 25 hydrolase, and 16 esterase genes. Notably, RT-qPCR results showed that from the predicted 13 genes related to fenvalerate degradation, the expression of six genes, including esterase, HAD family hydrolase, lipolytic enzyme, and gentisic acid dioxygenase, was induced in the presence of fenvalerate. In this study, the key genes and degradation mechanism of C. freundii CD-9 were analyzed and the results provide scientific evidence to support its application in environmental bioremediation.
The Tsunamis Generated by the Hunga Tonga-Hunga Ha'apai Volcano on January 15, 2022
Authors: Lynett Patrick
Published: March 2022

On the evening of January 15th, 2022 at approximately 5:15 pm local time (4:15 am Greenwich Mean Time), the Hunga Tonga-Hunga Ha'apai volcano unleashed a violent underwater eruption, blanketing the surrounding land masses in ash and debris (1). The eruption generated tsunamis observed throughout the globe. The last time such an event occurred was the 1883 Krakatau eruption (2), and thus here we have the first observations of a tsunami from a large emergent volcanic eruption captured with modern instrumentation. The mechanisms of tsunami generation here are rare and complex, but a wealth of observations permit a forensic analysis. With the use of oceanographic and meteorological data, post-event field survey observations, and high-order hydrodynamic modeling, we show that the event generated tsunamis at different times and from distinct mechanisms. There is evidence of a relatively small wave generated through a pre-cursor source approximately 10 minutes before the primary eruption; due to lack of observational data, it is difficult to specify the source of these waves, but a submarine landslide associated with an early eruption is possible. The main eruption appears to have generated waves through multiple mechanisms, including: 1) air-sea coupling with the initial and powerful shockwave radiating out from the explosion in the immediate vicinity of the eruption, 2) the collapse of the water-crater created by the underwater explosion, and 3) air-sea coupling with the air-pressure wave that circled the earth multiple times, leading to a global tsunami. In the nearfield, the tsunami impacts are strongly controlled by the shockwave and water-crater source, while the far-field tsunami, which was uncommonly persistent, can be largely described by the air-pressure wave mechanism. Catastrophic damage in some harbors in the far-field was averted by just 10’s of cm, implying that a modest sea level rise combined with a future, similar event would lead to a step-function increase in infrastructure impacts. Piecing together the complexity of this event has broad implications to the hazard in similar geophysical
Assessing the Impact of Biodiversity (Species Evenness) on The Trophic Position of an Invasive Species (Apple Snails) in Native and Non-Native Habitats Using Stable Isotopes.
Authors: Scriber II Kevin Emmanuel , France Christine A.M. , Jackson Fatimah L.C.
Published: March 2022

Invasive apple snails negatively impact non-native habitats and also human well-being. Here the trophic position of Pomacea canaliculata in native habitats (Maldonado, Uruguay) and non-native habitats (Hangzhou, China and Hawaii, USA) are compared to explain their differential impacts therein. Detritus samples and tissue samples from apple snails were collected in all sites. Apple snail trophic levels were calculated as the difference between the mean δ15N values of detritus samples and corresponding apple snail tissue samples, divided by the mean δ15N fractionation for nitrogen per trophic level in freshwater habitats. The mean δ15N values of detritus in sites served as a baseline (i.e.: zero trophic level), allowing for direct comparisons. Linear regression analysis established correlation between species evenness and apple snail trophic level (R2 = 0.8602); in line with a Pearson's product-moment correlation value (-0.83) and 95% Confidence Interval (-0.87, -0.77). Normal quartile plots indicated two normally distributed subsets of apple snail trophic level data: (1) a biodiverse subset containing the Uruguayan and Chinese Lake Sites and (2) the homogenized Hawaiian and Chinese Creek Sites. A precipice value for species evenness, between (3.7) and (2.4), once descended to, or beneath, separates, statistically distinct, normal distributions of invasive apple snail trophic level data from diverse versus homogenized habitats. This value is akin to a fence separating biodiversity from homogenization, or habitats exhibiting biotic resistance from others with open niche space. This plausible mechanism explains invasive apple snails’ variable ecological impacts in native versus non-native habitats, and may predict the latters’ susceptibility to adverse impacts.
Relationship between peripheral blood eosinophil count and the severity and prognosis of children with Duchenne Muscular Dystrophy : a new potentially useful predictor?
Authors: Jiang Zhi , Liao Hongmei , Wu Liwen , Hu Wenjing , Yang Liming , Chen Bo , Ning Zeshu , Tang Jingwen , Xu Rong , Chen Mei , Guo Feng , Liu Shulei
Published: March 2022

Objective To investigate the effect of peripheral blood eosinophil count on the severity and prognosis of Duchenne Muscular Dystrophy（DMD).Method The clinical data of 145 patients with DMD and 150 normal healthy children in the same period were collected retrospectively. The results of the two groups were analysed and compared. Logistic regression and Cox regression analysis were used to explore the influence of eosinophils on DMD. The relationship between eosinophils and the long-term efficacy and prognosis of DMD were followed up.Result Compared with the control group, the eosinophil count of children in DMD group was slightly lower(Z=2.163,p=0.031).Eosino-phil count at visit and follow-up was slightly negatively correlated with muscle strength score to visit and follow-up, and the correlati-on coefficients were as follows: ρ=-0.245，p=0.040，ρ=-0.137，p=0.032.Eosinophils were the protective factor for high muscle strength score of visit,OR=0.007,95%CI(0.001-0.276)，p=0.008,OR=0.038,95%CI(0.002-0.752), p=0.032 after adjusting for age and other factors. Eosinophils were also the protective factor for elevated muscle stre-ngth score at follow-up visit,(OR=0.012,95%CI0.001-0.645,p=0.029), after adjusting for age and other factors (OR=0.033,95%CI0.001-0.121,p=0.039). Univariate analysis found that eosinophils affected the curative effect during follow-up visit, HR=2.739,95%CI(1.294-5.979)p=0.008. Further adjustment for age and other factors multivariate Cox regression analysis found that eosinophils affected the curative effect(HR=1.127,95% CI 1.109-1.246,p=0.020）.Conclusion The eosinophil count in peripheral blood was related to the severity of DMD, and can predict the curative effect and prognosis to a certain extent. Eosinophil count may be a potentially useful predictor.
Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis
Authors: Mameri Hamza , Denery-Papini Sandra , Gaudin Jean-Charles , Lollier Virginie , Tranquet Olivier , Brossard Chantal , Pietri Manon , Marion Didier , Codreanu-Morel Fanny , Beaudouin Etienne , Wien Frank , Gohon Yann , Briozzo Pierre
Published: March 2022

Lipid transfer proteins (LTPs) were identified as allergens in a large variety of pollens and foods, including cereals. LTPs belong to the prolamin superfamily and display an α-helical fold, with a bundle of four α-helices held together by four disulfide bonds. Wheat LTP1 is involved in allergic reactions to food such as anaphylaxis and wheat-dependent exercise-induced anaphylaxis. To identify critical structural elements of antibody binding to wheat LTP1 in the context of food allergy to wheat, we used site-directed mutagenesis on wheat recombinant LTP1. We evaluated the modifications induced by these mutations on LTP1 secondary structure by synchrotron radiation circular dichroism and on its antigenicity with patient’s sera and with mouse monoclonal antibodies. Disruption of the C28-C73 disulfide bond significantly affected IgE-binding and caused protein denaturation, while removing C13-C27 bond decreased LTP1 antigenicity and slightly modified LTP1 overall folding. In addition, we showed Lys72 to be a key residue; the K72A mutation did not affect global folding but modifid the local 3D structure of LTP1 and strongly reduced IgE-binding. This work revealed a cluster of residues (C13, C27, C28, C73 and K72), four of which embedded in disulfide bonds, which play a critical role in LTP1 antigenicity.
Predictors of Shorter- and Longer-Term Mortality after COVID-19 Presentation among Dialysis Patients: Parallel Use of Machine Learning Models in Latin and North American Countries
Authors: Guinsburg Adrián M , Jiao Yue , Bessone María Inés Díaz , Monaghan Caitlin K , Magalhães Beatriz , Kraus Michael A , Kotanko Peter , Hymes Jeffrey L , Kossmann Robert J , Berbessi Juan Carlos , Maddux Franklin W , Usvyat Len A , Larkin John W
Published: March 2022

Background:
We developed machine learning models to understand the predictors of shorter-, intermediate-, and longer-term mortality among hemodialysis (HD) patients affected by COVID-19 in four countries in the Americas.
Methods:
We used data from adult HD patients treated at regional institutions of a global provider in Latin America (LatAm) and North America who contracted COVID-19 in 2020 before SARS-CoV-2 vaccines were available. Using 93 commonly captured variables, we developed machine learning models that predicted the likelihood of death overall, as well as during 0–14, 15–30, > 30 days after COVID-19 presentation and identified the importance of predictors. XGBoost models were built in parallel using the same programming with a 60%:20%:20% random split for training, validation, & testing data for the datasets from LatAm (Argentina, Columbia, Ecuador) and North America (United States) countries.
Results:
Among HD patients with COVID-19, 28.8% (1,001/3,473) died in LatAm and 20.5% (4,426/21,624) died in North America. Mortality occurred earlier in LatAm versus North America; 15.0% and 7.3% of patients died within 0–14 days, 7.9% and 4.6% of patients died within 15–30 days, and 5.9% and 8.6% of patients died > 30 days after COVID-19 presentation, respectively. Area under curve ranged from 0.73 to 0.83 across prediction models in both regions. Top predictors of death after COVID-19 consistently included older age, longer vintage, markers of poor nutrition and more inflammation in both regions at all timepoints. Unique patient attributes (higher BMI, male sex) were top predictors of mortality during 0–14 and 15–30 days after COVID-19, yet not mortality > 30 days after presentation.
Conclusions:
Findings showed distinct profiles of mortality in COVID-19 in LatAm and North America throughout 2020. Mortality rate was higher within 0–14 and 15–30 days after COVID-19 in LatAm, while mortality rate was higher in North America > 30 days after presentation. Nonetheless, a remarkable proportion of HD patients died > 30 days after COVID-19 presentation in both regions. We were able to develop a series of suitable prognostic prediction models and establish the top predictors of death in COVID-19 during shorter-, intermediate-, and longer-term follow up periods.
The acceptability and utility of Indigenous youth health assessments: A narrative systematic review
Authors: Fraser Jed , Askew Deborah , Mahoney Ray , Spurling Geoffrey
Published: March 2022

Background:The time between childhood and adulthood is when an individual acquires the physical, cognitive, social, and economic resources that are foundational to health and wellbeing later in life. The psychological and physiological transitions of youth are compounded by profound transitions in social role, including those related to employment, education, and family role. Additionally, Indigenous youth are developing their cultural identity while also contending with challenges of ongoing colonisation and everyday lived experiences of racism which negatively impacts their health and wellbeing. A comprehensive assessment of Indigenous youths’ health and wellbeing could enable early diagnosis and respond to physical and mental ill health concerns. This narrative systematic review synthesizes evidence about the acceptability and utility of primary health care-based health assessments for improving the health and wellbeing of Indigenous youth.Methods:A systematic search strategy was applied to 20 electronic databases (four bibliographic and 16 grey literature). Studies were included if they reported on health assessments conducted in primary health care with youth aged 12–24 years who were Indigenous to Australia, New Zealand, Canada, United States of America (USA), Taiwan, and the arctic regions of Scandinavia and Russia. Two independent reviewers performed the study selection, quality appraisal and data extraction. A narrative synthesis was undertaken.Results:Of the 3061 unique studies identified, seven met the eligibility criteria and were included: four mixed-methods studies, two qualitative studies and one quantitative study. Included studies showed youth health assessments were useful for making new diagnoses, detecting social and emotional wellbeing concerns, and some biomedical parameters. Co-created health assessments with Indigenous youth conducted by clinicians familiar to community were well accepted. Digital health assessments administered using an electronic tablet provide advantages. No health outcomes were reported. Additionally, no health assessments addressed the impacts of colonisation and racism.Conclusion:There is insufficient evidence to make firm conclusions about benefits of health assessments; however, health assessments can be useful for detecting new diagnoses and concerns regarding social determinants of health and social and emotional wellbeing. Future development of Indigenous youth health assessments needs to involve Indigenous youth’s perspectives, ideas and, interpretations of health.
The novel DNA binding mechanism of ridinilazole, a precision Clostridiodes difficile antibiotic.
Authors: Mason Clive , Avis Tim , Hu Chenlin , Nagalingam Nabeetha , Mudaliar Manikhandan , Coward Chris , Begum Khurshida , Gajewski Kathleen , Alam M Jahangir , Moss Stephen , Reich Stefanie , Duperchy Esther , Fox Keith , Garey Kevin , Powell David
Published: March 2022

Clostridioides difficile infection (CDI) causes substantial morbidity and mortality worldwide with limited antibiotic treatment options. Ridinilazole is a precision bisbenzimidazole antibiotic being developed to treat CDI and reduce unacceptably high rates of infection recurrence in patients. Although in Phase 3 clinical development, the precise mechanism of action by which ridinilazole elicits its bactericidal activity has remained elusive. Here we present conclusive biochemical and structural data to demonstrate that ridinilazole has a primary DNA binding mechanism, with a co-complex structure confirming binding to the DNA minor groove. Additional RNA-seq data indicated early pleiotropic changes to transcription, with broad effects on multiple C. difficile compartments and significant effects on energy generation pathways particularly. DNA binding and genomic localization was confirmed through confocal microscopy utilizing the intrinsic fluorescence of ridinilazole upon DNA binding. As such, ridinilazole has the potential to be the first antibiotic approved with a DNA minor groove binding mechanism of action.