bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytotoxicity and Cell Death Induction on a Cervical Cancer Cell Line by Crude Extracellular Product of Omphalotus nidiformis (Agaricomycetes) Mycelium
Authors: Tello-Salgado Isaac , Torres-Obando Alexzandra , Mir-Garcia Marisol , Guzmán-Razón Vanessa , Urquiza Veronica-Nuñez , Nava-García Elizabeth , Montiel-Arcos Elizur , Díaz-Hernández María T. , Mojica-Cardoso Carlos , Contreras Ochoa Carla O.
Published: November 2024

Fungi have proved to be useful sources of compounds with antineoplastic properties. Although several metabolites isolated from species of the genus Omphalotus have shown cytotoxic effects on tumor cell lines. Few works have studied Omphalotus nidiformis. The activity of a whole crude extracellular product of a O. nidiformis micelyum strain is reported herein; this crude extract was able to reduce viability of cervical cancer HeLa cells (78% to 29%) after 24 h of exposure. Upon fractionation with dichloromethane, the fraction F1 was also capable of inhibiting cell viability, but the fraction F2 showed no effect. Both the crude extracellular product and F1 induced time- and concentration-dependent cell death by apoptosis through activation of caspase-3/7; in addition, both products induced a 3.5- to 5-fold increase in autophagy. The major components identified in both extracts by gas chromatography/mass spectrometry were 9-octadecenamide, tetradecanamide, hexadecanamide, and squalene, which could be responsible for the cytotoxic effect. Fungal metabolites with cytotoxic activity could be used in the future in combination with antineoplastic drugs for cancer treatment.
Word order in the context of extensional and intensional events in Austrian Sign Language (ÖGS)
Authors: Krebs Julia , Wilbur Ronnie
Published: November 2024

This study examines the impact of the semantics of events and their participants on syntax (word order) in Austrian Sign Language (ÖGS), replicating and extending findings on other sign languages (Napoli et al. 2017). We tested the hypothesis that in the visual modality, intensional and extensional events are preferentially expressed by different word orders: verbs expressing an intensional event are preferred before the object and verbs expressing an extensional event are preferred after the object. To test this pattern for ÖGS and whether animacy of the object argument contributes to these preferences, Deaf signers were asked to sign transitive relations involving extensional and intensional events in non-reversible and reversible contexts. Results indicate systematic differences between verb types. Subject-object-verb order (SOV), the basic ÖGS word order, was preferred for extensional events, while subject-verb-object order (SVO) was more prevalent with intensional events, which also showed more complex structures. Unlike prior research, we did not find a preference for SVO orders due to argument reversibility, which had been suggested to reflect iconicity in the visual modality. We reconsider how extensional/ intensional are traditionally defined and suggest that while both are relevant to word order decisions in ÖGS, imputed iconicity loses any explanatory value it might have had if the stimuli more narrowly compared creation and non-creation verbs.
¿Qué textos escritos se usan en el ejercicio profesional de comercio exterior en China? Análisis de necesidades para la enseñanza-aprendizaje de ELE
Authors: Zhai Hong , Álvarez Álvarez Manuela
Published: November 2024

This article aims to identify what type of written texts are produced or translated in the professional practice of foreign trade between China and Spanish-speaking countries. Based on a needs analysis approach to teaching, a qualitative study is carried out in which, based on semi-structured interviews, information is collected from 29 participants from three groups: Spanish teachers; foreign trade teachers, and businessmen or employees dedicated to the commercial sector. The results provide a detailed image of the diversity and complexity of written uses in Spanish in this professional context: commercial, financial, legal-administrative and other protocol-type texts. These findings are essential for their implications in the teaching-learning of Spanish for specific purposes in foreign trade in the Chinese context.
Effectiveness of a Nursing Intervention to Improve Knowledge, Attitudes, and Practices in Malaria Prevention in an Emberá Katío Community in the Department of Córdoba
Authors:   Universidad de Córdoba, Herrera Herrera Jorge Luis , Rodríguez-Gázquez María de los Ángeles ,   Universidad de Antioquia, Rojas Juan Guillermo ,   Universidad de Antioquia
Published: November 2024

Objective. To evaluate the effectiveness of a nursing intervention, against routine care, to improve knowledge, attitudes, and practices (KAP) in malaria prevention in an Emberá Katío community from the department of Córdoba, Colombia. Methods. This was an intervention study with quasi-experimental design with control group, conducted in three phases: (I) design of the educational intervention, (II) content validation of the educational intervention through expert judgment, and (III) execution of a quasi-experimental study with two groups: experimental (n = 60) and control (n = 58). The intervention consisted in four modules taught in person, using educational strategies, like classes, guided discussions, workshops, and a booklet designed for the study. The control group received the routine care provided by the Secretariat of Health. The study used the instrument by the Pan-American Health Organization “Survey on knowledge, attitudes, and practices in addressing malaria in indigenous communities” to measure pre- and post-intervention scores. Results. The four modules of the educational intervention obtained Content Validity Indices between 0.83 and 0.90 that are considered adequate. The General Linear Models of repeated measures showed positive effect of the educational intervention on the KAP scores (p < 0.001), with an effect size of 91% in knowledge, 49% in attitudes, 85% in practices, and 93% in the total score. Conclusion. The educational intervention proved effective to improve KAPs in malaria prevention in the Emberá Katío community from the department of Córdoba.
Features of hematological indices in cataract in the dynamics of surgical treatment
Authors: Smirnova Olga V. , Zinkina Tatyana O.
Published: November 2024

BACKGROUND: Cataract is one of the most common ophthalmologic diseases leading to blindness.
AIM: To study the features of hematological indices in men over 40 years old with different types of cataract before and after surgical treatment.
MATERIAL AND METHODS: The examination groups included 25 patients (25 eyes) with opacities localized in the cortical substance of the lens, 19 (19 eyes) with total opacities, 26 (26 eyes) with nuclear opacities, 30 (30 eyes) with subcapsular opacities; of these, 43 patients (43 eyes) had initial cataract, 39 (39 eyes) — immature, 18 (18 eyes) — mature cataract. The control group consisted of 30 people. All study participants underwent a complete ophthalmologic examination and assessment of hematological indices. The following integral hematological indices were calculated using generally accepted formulas: lymphocyte index (lymphocytes/neutrophils); leukocyte intoxication index; neutrophil/lymphocyte ratio index; neutrophil/monocyte ratio index; lymphocyte/monocyte ratio index; lymphocyte/eosinophil ratio index; leukocyte ratio and erythrocyte sedimentation rate index. Statistical analysis was performed using the Statistica 10 package. The Kruskal–Wallis and Mann–Whitney nonparametric tests were used to assess differences in the groups. The critical level of statistical significance when testing scientific hypotheses was p 0.05.
RESULTS: At all stages of cataract maturity, before and after surgery, unidirectional changes in the hematological indices were revealed: the lymphocyte and eosinophil ratio decreased (1.4–2.0; p=0.01), the neutrophils and monocytes (1.3–2.1; p=0.04), lymphocytes and monocytes (1.4–2.5; p=0.02) ratios, leukocytes and erythrocyte sedimentation rate (2.9–6.8; p=0.01) increased. In immature cataract, the intoxication index according to the hematological indices increased by 2 times in the dynamics of surgical treatment. At the same time, multidirectional changes in the hematological indices were revealed in cortical and subcapsular opacities of the lens, unidirectional changes — in nuclear and total opacities.
CONCLUSION: Patients with nuclear and total cataracts have the greatest number of disturbances in the ratio of cell populations according to hematological indices, therefore they constitute a risk group for the development of complications.
Advances in Optimization With Applications to Biodiversity Conservation
Authors:   , Buhler Cassidy Kim , Benson Hande Yurttan
Published: November 2024

In this dissertation, we explore the intersection of the fields of operations research and biodiversity conservation. The first part of this work involves improving unconstrained optimization methods for nonlinear programming, with special emphasis on methods for solving large-scale machine learning problems. The second part of this work uses optimization models and methods to make conservation decisions that achieve ecological goals. Conjugate gradient minimization methods (CGM) and their accelerated variants are widely used in machine learning applications. We focused on the use of cubic regularization to improve the CGM direction independent of the step length (learning rate) computation. Using Shanno's reformulation of CGM as a memoryless BFGS method, we derive new formulas for the regularized step direction, which can be evaluated without additional computational effort. The new step directions are shown to improve iteration counts and runtimes and reduce the need to restart the CGM. When CGM is applied to machine learning problems, numerical testing shows similar performance to existing algorithms. The resulting method has been implemented in Python, MATLAB, and C for distribution. Then, we examine spatial conservation planning as an application of optimization. To promote biodiversity and combat climate change, decision-makers collaborate to select which parcels of land to protect in order to meet ecological goals with various constraints. We propose an integer programming optimization model that considers the presence of multiple species on these parcels, subject to predator-prey relationships and crowding effects. By simulating these interactions, we find that the optimal reserve differs from reserves designed without these conditions. Finally, we explore a derivative-free optimization framework paired with a nonlinear component, population viability analysis (PVA). Formulated as a mixed-integer nonlinear programming (MINLP) problem, our model allows for linear and nonlinear inputs, continuous and discrete variables, and can be paired with existing ecological software. Connectivity, competition, crowding, and other similar concerns are handled by the PVA software, rather than expressed as constraints of the optimization model. In addition, we present numerical results that serve as a proof of concept, showing our models yield protected areas with similar expected risk to that of preserving every parcel in a habitat, but at a significantly lower cost. Our contributions to the field include improving CGM for unconstrained nonlinear programming problems and machine learning applications, incorporating more advanced species interactions in spatial conservation planning optimization models, and merging state-of-the-art optimization with state-of-the-art ecology models to promote interdisciplinary collaboration.
Karakteristik Fisik dan Kimia Edible Film Maizena dengan Penambahan Ekstrak Kayu Secang (Caesalpinia Sappan L.)
Authors: Ayudianty Laras , Dewi Yohana Sutiknyawati Kusuma , Priyono Suko
Published: November 2024

The purpose of this research was to obtain the concentration of secang wood extract that produces the best physcochemical characteristics of maizena edible fim. This study used randomized block design (RBN) with one factor and five replications. The factor of this study was the addition of secang wood extract into maizena edible film which consisted of five levels, namely s0 (0%); s1 (1%); s2 (3%); s3 (5%); and s4 (7%). Analysis of physical and chemical characteristics include thickness, solubility, water holding capacity, antioxidant activity, and total flavonoid compound. The best edible film was selected by De Garmo test. The result showed that 7% of secang wood concentration made the best physcochemical characteristics of maizena edible film with 0,154 mm of thickness, 43,253% of solubility, 4,111 (g/g) of Water Holding Capacity (WHC), 96,485% of antioxidant activity, 252,727 mg QE/g extract of total flavonoid compound.
Редкие опухоли. Метастатический рак носоглотки
Authors: Болотина Л. В.
Published: November 2024

Рак носоглотки (РН) является уникальной патологией, для которой характерна специфическая эндемичность, половые и возрастные особенности распределения, а также высокая чувствительность к консервативным методам лечения. Одной из особенностей РН является высокая ассоциация с вирусом Эпштейна-Барр (ВЭБ), что определяет особенность функционирования сигнальных путей и высокую иммуногенность опухоли.

Статья посвящена анализу исследований химио-иммунотерапии в 1 линии лечения рецидивного / метастатического РН.
Мультицентровое рандомизированное исследование пролонгированной антибиотикопрофилактики при цистэктомии в клиниках, работающих по протоколу раннего послеоперационного восстановления (ERAS)
Authors: Беркут М. В. , Беляев А. М. , Галунова Т. Ю. , Тяпкин Н. И. , Рева С. А. , Носов А. К.
Published: November 2024

Стандартная 24‑часовая антибиотикопрофилактика (АП) широко используется для минимизации риска осложнений с инфекцией в течение 30 дней после радикальной цистэктомии (РЦЭ). Однако значительное разнообразие протоколов, комбинаций антибактериальных препаратов и продолжительность назначения не предотвращают высокий уровень инфекционных осложнений после операции, частота которых может достигать 37–67 %.

Целью настоящего исследования является оценка риска развития инфекционных осложнений в период 30 дней после РЦЭ в хирургическом стационаре, работающем по протоколу ERAS при сравнении стандартного 24‑часового режима АП в сравнении с 120‑часовым (пролонгированный режим).

Материалы и методы: 92 пациента были рандомизированы в соотношении 1:1 на стандартный 24‑часовой режим антибиотиков (стандартная АП) и пролонгированный режим с применением меропенема в течении 120 часов. В данной работе были рассмотрены вторичные конечные точки — динамика биомаркеров системного воспалительного ответа и частота развития приобретенных карбапенемаз на фоне пролонгированной АП.

Результаты: Исходные и периоперационные характеристики были сбалансированы между группами. Анализ системного воспаления не выявил значимых изменений уровня системного воспалительного ответа в динамике на 1‑е и 14‑е сутки после операции (р = 0,791 и р = 0,219). При этом динамика уровня СРБ была менее интенсивная в группе пролонгированной АП, особенно на 1‑е сутки после операции (р = 0,020). Чаще всего выявлялись карбопенемазы классов B и D, ассоциированные с повышенным риском инфекционных осложнений. Кроме того, в группе пролонгированной АП отмечено снижение встречаемости карбопенем‑продуцирующих штаммов (p = 0,111), где регрессионный анализ показал связь между выявлением карбопенемаз и развитием инфекционных осложнений (ОР 2,73, p = 0,024).

Выводы: Данное проспективное рандомизированное исследование демонстрирует, что пролонгированная антибиотикопрофилактика эффективно снижает 30‑дневные послеоперационные осложнения после радикальной цистэктомии, при этом обеспечивая менее выраженный подъем С‑реактивного белка и не увеличивая частоту антибиотикорезистентности, что открывает новые горизонты для обновления протоколов в онкохирургии.
Outcome of single-ventricle patients supported with extracorporeal membrane oxygenation
Authors: Ali Majid , Alheraish Yasser A. , Shahzad Muhammad , Hakami Emad , Ibhais Mohammad , Rizvi Syed K. , Alsomali Ahlam
Published: November 2024

Background: Single ventricle heart disease can be left or right ventricle dominant congenital heart disease mostly associated with other risk factors like low birth weight, Preterm, chromosomal abnormality and all these risk factor associated with increase mortality.
Methods: A retrospective chart review of paediatric patients from neonatal age to 14 years since 2012 to 2021, with supported by extracorporeal membrane oxygenation (ECMO) including both single ventricle heart physiology and biventricular heart, admitted in paediatric cardiac surgical intensive care unit in our hospital was conducted. All data were compared between single ventricle heart physiology and biventricular heart. Data was performed using commercially available software (SPSS), with statistical significance set p<0.05.
Results: We enrolled total 124 patients who underwent ECMO cannulation. 68 children had single ventricle, while 56 being biventricular heart. Most children acquired ECMO cannulation in CICU 63 (50.8%). Male to female ratio was 74:50. 70.2% children got the ECMO cannulation when they had already been operated for surgical repair.
Conclusions: Paediatric ECMO utilization in SV is valuable and recently its utilization has been increased in it with improve survival.
A comparative evaluation of a commercially available kojic acid and arbutin-containing test product with a test regime in the treatment of hyperpigmentation
Authors: Joshi Rajiv , Sen Dyotona , Choudhary Sanjay
Published: November 2024

Background: The study compared the effectiveness of kojic acid and arbutin-containing lotion (alone) with arbutin-containing facewash and kojic acid and arbutin-containing lotion in the reduction of pigmentation.
Methods: The study compared the test product (lotion) and the test regime (lotion + facewash) over a period of 45 days. In both test groups, a thin layer of advance body lotion was applied to the face, neck, and upper trunk. In the test regime group (TRG), these areas were washed with advance facewash before the lotion was applied. Both groups used sunscreen (with a sun protection factor of 50). The primary outcomes measured were (i) skin radiance and skin pigmentation, (ii) skin gloss, and (iii) skin hydration. The secondary outcomes measured were clinical evaluation and a subjective self-assessment for tolerance and perception of the product.
Results: The study included 61 participants. The TRG showed a statistically significant increase in skin hydration (at 21 days) and skin gloss compared to the test product group (TPG) (at 21 and 45 days) (p<0.05). The majority of participants in both groups reported a visible reduction in pigmentation and improved facial glow and hydration as compared to baseline. No serious adverse effects were reported.
Conclusions: The use of kojic acid and arbutin-containing lotion alone and arbutin-containing facewash with the lotion led to significant improvements in skin radiance, lightening, gloss, and hydration as compared to the baseline, with the TRG showing significantly better clinical results than the TPG in terms of skin hydration and gloss.
On the issue of the influence of cooperative relations on the efficiency of the implementation of state defense orders
Authors: Chernyaev Eugene V.
Published: November 2024

The subject of this study is the cooperation of participants in the implementation of the state defense order of the Russian Federation, which plays a key role in ensuring national security and technological development of the country. The study examined the theoretical foundations of cooperation in the implementation of the state defense order, analyzed the existing models of cooperation between participants in the state defense order. Using the mathematical apparatus, an assessment of the effectiveness of the management of the cooperation system was carried out using one of the cooperation models as an example. Conclusions were made regarding the conditions for the formation of stable and sustainablecooperation.
System of performance indicators of the ESG–concept: state and prospects for assessment
Authors: Avakov Vitaly A. , Shinkevich Alexey I.
Published: November 2024

In the world community, the concept of sustainable development has firmly established itself as a priority trend of globalization through the transformation of key development vectors into the format of the ESG–concept, within which the performance of enterprises is expressed by indicators characterizing care for the environment, personnel, transparency and efficiency of social activities. The main emphasis is on the formation of anti-corruption activities, ensuring the transparency of enterprise reporting, information openness, the use of modern management tools within the framework of the Industry 5.0 concept, eliminating gender, social and other conflicts, comprehensively ensuring a good image of the organization. In these conditions, the creation of international ratings of compliance of enterprise policies with the ESG–agenda is being updated. At the same time, there is a lack of a unified methodology for assessing the performance indicators of the ESG–concept, in the form of a unified reporting form for enterprises. The purpose of the study is to develop ESG–monitoring based on systematization of indicators in priority areas of activity and calculation of the integral ESG–indicator. The scientific novelty lies in the development of an ESG–monitoring model, which is a decomposition diagram of the organization of ESG–monitoring of enterprises in IDF0 notation as part of the implementation of the state strategy for transplantation of sustainable development goals, including the formation of a list of indicators, the development of a unified methodology for their calculation, the development of a unified form of statistical reporting, and monitoring with current frequency. The proposed toolkit is a promising mechanism for government regulation, by ranking and comparing enterprises according to the level of compliance with the ESG–concept, to create an accurate investment impulse in the field of transplantation of sustainable development goals and ensuring the homeostasis of economic systems in conditions of uncertainty and instability of the external environment.
Dążenie sądu do konsensualnego załatwienia sprawy cywilnej. Uwagi na tle art. 10, art 183(8), a także art. 205(6) § 2 oraz art. 223 § 1 k.p.c.
Authors: Sowiński Piotr
Published: November 2024

Tekst podejmuje problematykę prokonsensualnej aktywności sądów orzekających w sprawach cywilnych. Dostrzega się w nim, że pomimo wprowadzenia do polskiego systemu prawa instytucji mediacji, sądy nadal związane są dyrektywą zawartą w art. 10 kodeksu postępowania cywilnego. W myśl tej dyrektywy powinny one dążyć do ugodowego załatwiania tych spraw, co rodzi po ich stronie określone obowiązki procesowe, nie tylko informacyjne.
EXPRESSÕES DA “QUESTÃO SOCIAL” NA AMAZÔNIA: apontamentos sobre exploração mineral, saúde e envelhecimento
Authors: Hauradou Gladson Rosas , Lima Luziene Batalha , Souza Greyssy Kelly Araujo de , Picanço Dayana Feitosa , Silva Leiliane Amazonas da , Batista Amanda Maciel
Published: November 2024

Neste artigo, refletimos sobre a “questão social” na Amazônia, a partir de três eixos centrais: a exploração mineral, a saúde em Parintins (AM) e o envelhecimento em Parintins (AM). O objetivo é problematizar as expressões da “questão social” na Amazônia, em suas distintas “Amazônias”, com enfoque nos processos de exploração mineral e aprofundamento das desigualdades sociais, territoriais e geracionais em curso na região. Do mesmo modo, refletimos sobre as nuances e as particularidades que as expressões da “questão social” adquirem na contemporaneidade ao nível local e regional. Finalmente, a proposta é construir uma reflexão crítica sobre a “questão social”, trazendo à luz elementos e categorias necessários à apreensão dos fenômenos na sua totalidade, bem como sobre as políticas públicas presentes na região acerca das temáticas supracitadas.
O FEMININO NEGRO: corpos afetados pelas faces da opressão e da desigualdade racial
Authors: Silva Carla Cecília Serrão , Braga Ivana Márcia Moraes , Silva Pedro Igor Nascimento da , Gomes Sarah Fernanda Moraes
Published: November 2024

O presente artigo aborda os marcadores sociais de classe, gênero e raça como categorias definidoras do lugar para o qual foram socialmente destinadas as mulheres negras no Brasil. Apresenta elementos da razão universal conservadora para explicar o racismo como recurso de desumanização de corpos distintos do padrão europeu, que explicam como na contemporaneidade as mulheres negras são sentenciadas a viver expostas a situações de pobreza e exploração permanentes. Problematiza contextos sócio-históricos que condicionaram as mulheres negras a ocuparem funções como a de trabalhadora doméstica, marcada por relações escravistas de exploração e sujeição. Registra as crises sanitárias mais recentes como expressões do racismo e da desigualdade de gênero que afetam a vida das mulheres negras e de suas famílias, de variadas formas. Nesse percurso, propõe reflexões importantes acerca das concepções conservadoras e racistas responsáveis por sustentar a opressão e a desigualdade racial, de forma particular, na vida das mulheres negras neste país.
POLÍTICA EDUCACIONAL DE ENSINO MÉDIO EM TERRITÓRIOS MUNICIPAIS DA AMAZÔNIA PARAENSE: análises de algumas efetivações
Authors: Nascimento Afonso Welliton Sousa , Cardoso Maria Bárbara da Costa , Pereira Maria do Socorro Vasconcelos
Published: November 2024

O artigo tem o objetivo de analisar algumas instâncias de efetivação das políticas educacionais de Ensino Médio (EM) em seis municípios da Amazônia paraense. A análise decorre de problematizações sobre o EM ofertado nessas regiões, que permitem compreender a materialização das políticas nesses espaços formativos. Por meio da pesquisa bibliográfica e documental, com acesso a dados oficiais sobre a oferta da etapa nessas localidades, considerando o período de 2015 a 2021, foi identificado que as ações têm sido historicamente referendadas por fatores como a filantropia, a protelação, a fragmentação e a improvisação. Tal cenário evidencia como esses elementos impactam nos índices educacionais dos municípios analisados, os quais são alterados de modo lento e não demonstram continuidade de ação pública capaz de garantir estruturas adequadas para que os jovens possam ter condições reais de acessar um EM como proposto segundo as garantias e os marcos legais da educação.
SOCIOEDUCAÇÃO DO MARANHÃO: ações intersetoriais, práticas restaurativas, gestão participativa, planejamento e monitoramento das ações em meio fechado
Authors: Mendonça Doralice Silva , Aguiar Lúcia das Mercês Diniz , Silva Nikson Daniel Souza da , Inocentes Pollyana Gonçalves dos , Silva Priscilla Swaze Anchieta , Amorim Sorimar Sabóia , Setúbal Talita de Fátima Conceição , Barcelos Teresa Neumann Almeida
Published: November 2024

O presente artigo objetiva apresentar e analisar a execução do Atendimento Socioeducativo, considerando os princípios norteadores do SINASE e do Plano Nacional de Atendimento Socioeducativo. Nessa produção, apresentamos o conceito de gestão democrática e participativa; o princípio de intersetorialidade e responsabilização; a adoção de procedimentos restaurativos na construção de novas perspectivas de atendimento ao(à) socioeducando(a) e o monitoramento e avaliação do planejamento estratégico na Política Pública de Socioeducação no estado do Maranhão. A metodologia utilizada foi a pesquisa bibliográfica, com base em autores da área e do marco legal sobre a política socioeducativa.
TRANSFORMAÇÕES SOCIOECONÔMICAS E RECONFIGURAÇÕES TERRITORIAIS NA AMAZÔNIA NO INÍCIO DO SÉCULO XXI
Authors: Mesquita Benjamin Alvino de , Mota Francisco Lima , Madeira Welbson do Vale
Published: November 2024

Neste artigo, são analisadas transformações socioeconômicas e territoriais na Amazônia a partir do início do século XXI. Após uma síntese das principais fases da economia regional desde o início da etapa imperialista do capitalismo, a fase mais recente é examinada com base em três situações: a dinâmica da produção da soja na Amazônia e suas consequências em termos de aproveitamento da força de trabalho, a subordinação da política de zoneamento ecológico econômico no estado do Acre a interesses vinculados à produção de bens primários, com destaque para a pecuária e a soja, e a importância dos grandes projetos econômicos para viabilizar a produção e o escoamento de commodities minerais e agrícolas. Nesse caso, é feita uma ilustração do fato por meio de elementos de uma pesquisa sobre consequências da implantação de uma usina hidrelétrica no estado do Maranhão.
Polska literatura socrealistyczna
Authors: Mazurkiewicz Adam
Published: November 2024

W publikacji autor nie tylko poddaje pogłębionej interpretacji wybrane, nierozpoznane dotąd badawczo, a zarazem porządkujące epokę, motywy charakterystyczne dla socrealizmu, lecz także, w części pierwszej, prowadzi rozważania, które uznać można za rodzaj syntezy epoki i prądu literackiego otwierający drogę do spojrzenia analitycznego, zaproponowanego w części drugiej. Rozważania autora dotyczą m.in. pozornej monolityczności socrealizmu i próby jego periodyzacji, związków socrealizmu i konstruktywizmu, meandrów relacji między kulturą socrealistyczną i stalinowską a kulturą narodową, a także kwestii kluczowej: względów pozaartystycznych, decydujących o kształcie realizacji artystycznych.
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Epoka ta, jak bodaj żadna inna w powojennej historii kultury polskiej, podporządkowała literaturę wymogom pozaartystycznym. Na kształt dzieła wpływ miało przy tym nie tyle zapotrzebowanie społeczne, co wymogi propagandy. Walka z enigmatycznymi „formalizmami” (będąca w istocie pochodną propagandowej krytyki kultury Zachodu oraz międzywojnia) przyczyniła się – wespół z promocją czytelnictwa, postrzeganego jako świadectwo awansu społecznego – do uproszczenia języka artystycznego. W socrealizmie wyrażał on bowiem nie tyle koncepcję, przyświecającą artyście, ile zideologizowaną wykładnię oficjalnych poglądów.
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Detection of liver metastases by abbreviated MRI protocol in patient with pNET and severe chronic kidney disease
Authors: Winder Mateusz , Steinhof-Radwańska Katarzyna
Published: November 2024

Wykrycie przerzutów do wątroby we wczesnym stadium choroby ma kluczowe znaczenie dla poprawy przeżycia pacjentów. Guzy neuroendokrynne trzustki (pancreatic neuroendocrine tumors – pNETs) i ich przerzuty zwykle ujawniają się jako wcześnie i silnie wzmacniające się zmiany ogniskowe w tomografii komputerowej z kontrastem (contrast enhanced computed tomography – CECT). Jednak stosowanie dożylnych środków kontrastowych jest przeciwwskazane u pacjentów z ciężkimi zaburzeniami czynności nerek. Częstość występowania przewlekłej choroby nerek (chronic kidney disease – CKD) i nowotworów złośliwych wzrasta z wiekiem, co sprawia, że zarówno leczenie, jak i diagnostyka obrazowa są skomplikowanym procesem u starszych pacjentów chorych onkologicznie.
W niniejszym opisie przypadku przedstawiono ścieżkę diagnostyczną starszej pacjentki z długą historią pNET, u której w trakcie leczenia rozwinęła się ciężka CKD. U pacjentki rozpoznano przerzuty do wątroby w badaniu PET/CT, co potwierdzono skróconym protokołem rezonansu magnetycznego (abbreviated magnetic resonance imaging – AMRI) bez wzmocnienia kontrastowego, natomiast CECT nie wykazała przerzutów. Protokoły AMRI bez wzmocnienia kontrastowego mogą dostarczyć wystarczających informacji na temat obecności choroby przerzutowej wątroby u pacjentów leczonych onkologicznie ze współistniejącą CKD.
Cuerpo-tierra entre colapsos y Refugios
Authors: Azambuja Katiuska , Carneiro Maristela , Molina Saldarriaga Mónica Lucía
Published: November 2024

Refugio es una obra performativa realizada con mujeres en la ciudad de Várzea Grande, Brasil, en 2023. La propuesta se desarrolla en etapas poéticas, compuestas por dibujos, sonidos, cartas y un videoarte. La reflexión parte del texto La sociedad del cansancio (Han, 2015), en relación con el colapso climático. A partir de ello, se pregunta: ¿Cómo tener una vida radicalmente viva?, evocando el pensamiento de Ailton Krenak (2020) y Dènetém Bona (2020). El objetivo fue activar la escucha del cuerpo-tierra, expresión de la artista Ana Mendieta, en relación con la idea de la tierra-cuerpo, junto con el concepto original de aisthesis, con el cual, se construye subjetividades decoloniales (Mignolo, 2011). Estas ideas sobrepasan la dualidad cultura - naturaleza (Mignolo, 2017), y retoman la percepción de la naturaleza como ser vivo y las relaciones milenarias que sustentan la vida (Walsh, 2008). Como herramienta metodológica, se escogió la cartografía, por ser un antimétodo que exige una atención despojada de formación de subjetividades; la necesidad de acompañar procesos, por el contrario, exige habitar y reconocer un territorio existencial (Barros & Kastrup, 2015). Las participantes revelaron una percepción de ritmo/espacio más atento y una conciencia sobre la escucha del cuerpo-tierra y la tierra-cuerpo.
Recibir la lengua muda
Authors: Dalbem Lucas Martins
Published: November 2024

Este texto articula dos situaciones acusmáticas relacionadas a los estudios del lenguaje del filósofo Walter Benjamin: el sonido de la palabra y la relación entre el lenguaje de los hombres y el lenguaje de las cosas. En relación con estos estudios, se presenta una investigación artística que involucra sonidos basados ​​en textos y experimentos vocales que se sitúan contra la flecha del tiempo lineal y el vacío en la tradición del Occidente capitalista. Y, al fin, resuena en una reflexión crítica sobre el sonido y la escucha del sonido, combinados con los estudios del artista sonoro Frederico Pessoa sobre los sonidos producidos por las fábricas de la catastrófica extracción de minerales en la provincia de Minas Gerais, Brasil.
Association between sleep quality and polymorphisms of the genes COMT, HTR2A and FKBP5 in individuals with and without dentofacial deformity
Authors: Flores Elvira Katherine Barriga , Fanderuff Marina , Santos Katheleen Miranda dos , Meger Michelle Nascimento , Costa Delson João da , Storrer Carmen Lucia Mueller , Scariot Rafaela
Published: November 2024

Sleep is a fundamental biological function, and any disturbances can lead to alterations in an individual’s physical, occupational, cognitive, and social functioning. Aim: This study aimed to evaluate the quality of sleep and its association with factors such as age, sex, facial profile, and genetic polymorphisms in individuals who underwent dental treatment. Methods: The study comprised a total of 227 individuals. The “Sleep Assessment Questionnaire” was utilized to evaluate sleep quality. For the genetic assessment, oral mucosa cells were collected and markers from the COMT (rs174675, rs165656), HTR2A (rs4941573, rs6313), and FKBP5 (rs1360780, rs3800373) genes were selected for real-time PCR analysis. The data were subjected to statistical analysis with a significance level of 0.05. Results: The results showed that women had a poorer perception of sleep quality (p<0.05). There was a significant association between sleep quality and facial profile (p<0.05). Individuals with facial profiles I and II had a poorer perception of sleep quality in general and in the domains of non-restorative sleep, sleep time disturbance, and restlessness. Individuals with facial profile II had a poorer perception of sleep apnea than those with profile III (p=0.034). There was a significant association between the COMT rs174675 polymorphism and restlessness (p=0.035). Conclusion: The poorest perception of sleep quality was associated with women and individuals with facial profiles I and II. The poorest perception of restlessness was associated with COMT rs174675 polymorphism.
Impact of Aggregatibacter actinomycetemcomitans on epithelial repair
Authors: Mendes Bianca Carvalho , Stolf Camila Schmidt , Paz Hélvis Enri de Sousa , Arroteia Letícia Sandoli , Ramos Lucas de Paula , Santamaria Mauro Pedrine , Ruiz Karina Gonzalez Silvério , Monteiro Mabelle de Freitas , Casarin Renato Corrêa Viana
Published: November 2024

ABSTRACT: Normal wound healing occurs in four overlapping stages - hemostasis, inflammation, proliferation, and remodeling. In the oral cavity, these processes occur in an infectious environment. Among the pathogens found in the oral community, Aggregatibacter actinomycetemcomitans (Aa) constitutes a well-recognized periodontal pathogen responsible for expressing several virulence factors, which activate a host response. Aim: This study investigated whether Aa’s presence can interfere with oral keratinocyte tissue healing in an in vitro wound healing model. Methods: Two groups were defined: Group KO (n=5) and Group KO+Aa (n=5). The Aa (JP2 strains) were cultivated in anaerobiosis, and the total protein extract was obtained. The keratinocytes were cultivated with the medium of standard culture until their confluence. After confluence, plates were allocated to each group. With the pipette’s tip, a “scratch” was made in the middle of each well of the plate, and the cells were cultured at 37°C in a humidified atmosphere with 5% CO2. The cells received the stimulus according to groups, and, at times 0, 5, 10, 24, and 48 hours, the wound areas were visualized and standardly recorded using an inverted microscope. Results: When analyzing the timeframe, differences in wound measurements indicate a faster closure in the control group compared to the KO+Aa group, although not statistically significant. However, upon examining the wound closure measures, it was observed that the Aa protein extract significantly reduced wound closure at 10 and 48 hours (p<0.05), negatively impacting the keratinocyte’s behavior. Conclusion: In summary, it was demonstrated that the pathogen Aa can interfere with the re-epithelization in vitro.
Desafios e reflexões na Educação Física contemporânea
Authors: Scaglia Alcides José , Montagner Paulo Cesar , Silva Luis Felipe Nogueira
Published: November 2024

Este artigo expressa a entrevista realizada com o professor português Dr. Jorge Olímpio Bento, uma das grandes referências acadêmicas acerca da Pedagogia do Esporte, uma das disciplinas das Educação Física. O entrevistado é licenciado em Educação Física, Doutor em Educação e foi, durante 40 anos, docente da Faculdade de Desporto da Universidade do Porto (Portugal). O objetivo do registro passou por compreender sua trajetória acadêmica, em meio aos imbricamentos e acontecimentos provenientes de sua engajada participação e profícua produção intelectual, que impactaram a área da Educação Física e do Esporte, tendo por base o livro “Desporto: discurso e substância”. Ainda, buscou inspirar e guiar reflexões pedagógicas às novas gerações de professores e professoras de Educação Física e Esporte, visando a superação de questões paradigmáticas ainda hegemônicas nestas áreas, bem como o desenvolvimento e consolidação de caminhos outros, pavimentados pela ciência, por estudos e pesquisas recentes, que norteiam – ou deveriam - vindouras e urgentes transformações nas relações de ensino-aprendizagem.
Pain in Spinal Muscular Atrophy Type 2 and Type 3 Patients
Authors: Yücel Şen Arife Derda , Uğur Özlem , Yarar Coşkun , Carman Kursat Bora
Published: November 2024

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by degeneration of alpha motor neurons. It is a multisystemic disease affecting non-neuronal systems and quality of life. We aimed to investigate the prevalence and characteristics of pain in children with spinal muscular atrophy. In this single-center study, by using visual analog scales, 13 patients diagnosed with SMA type 2 and type 3 accompanied by their parents filled out a questionnaire involving questions about the presence of chronic pain, pain frequency, duration, location, and intensity, causes of pain, and coping methods. All patients reported that they experienced chronic pain. Patients with type 3 experienced pain more frequently than those with type 2—multiple times each month. The terms "minutes," "mild," and "intermittent" were most commonly used to describe the length, intensity, and course of the pain in both groups. The mean pain intensity according to Visual Analogue Scale were 35.526.3 mm in type 2 and 25.110.2 mm in type 3. The localization of pain was primarily concentrated in the back and lower extremities. The most common causes of pain were stretching exercises during physical therapy and posture disorder. The most common methods of coping with pain were distraction strategy and massage. Pain is a common problem in children with SMA. Management of the pain might increase the life quality of SMA patients. A multidisciplinary approach must be considered in the treatment of these children.
The role of generative artificial intelligence (GAI) in scientific research
Authors: Petrenko Anatolii
Published: November 2024

The emergence and growing capabilities of Generative Artificial Intelligence (GAI) are profoundly transforming scientific research. Although AI extends human intelligence by automating certain tasks, it complements rather than replaces human creativity. This article discusses the implications of AI for the scientific process, including ethical considerations and the need for a balanced approach that combines the strengths of human and artificial intelligence in the process of discovering knowledge and solving complex problems. The discussion extends to the need for universities to adapt their curricula to prepare future researchers for the AI era, emphasizing scenario-based thinking and uncertainty management as important skills for the future.
Reducing risk for assistive reinforcement learning policies with diffusion models
Authors: Tytarenko Andrii
Published: November 2024

Care-giving and assistive robotics, driven by advancements in AI, offer promising solutions to meet the growing demand for care, particularly in the context of increasing numbers of individuals requiring assistance. It creates a pressing need for efficient and safe assistive devices, particularly in light of heightened demand due to war-related injuries. While cost has been a barrier to accessibility, technological progress can democratize these solutions. Safety remains a paramount concern, especially given the intricate interactions between assistive robots and humans. This study explores the application of reinforcement learning (RL) and imitation learning in improving policy design for assistive robots. The proposed approach makes the risky policies safer without additional environmental interactions. The enhancement of the conventional RL approaches in tasks related to assistive robotics is demonstrated through experimentation using simulated environments.
NUMERICAL SIMULATION IN CALCULATIONS OF TECHNOLOGICAL SYSTEMS OF ELECTROMAGNETIC PROCESSING. PART I: PROPAGATION OF THE ELECTROMAGNETIC FIELD
Authors: Lavinsky Denys , Barbin Kostіantyn
Published: November 2024

The article deals with the problem of numerical modeling when calculating electromagnetic field propagation in electromagnetic molding systems. From the analysis of open information sources, it follows that the problem of numerical modeling when creating new technological operations of electromagnetic molding or when improving existing ones is relevant in a scientific and practical sense. This is due to the need to perform adequate numerical modeling and computational analysis of technological systems and technological operations at the stage of creation and improvement. With regard to technological systems of electromagnetic processing, calculation schemes and models should make it possible to study the propagation of a non-stationary electromagnetic field and to study the processes of nonlinear deformation of technological elements, which is caused by the force interaction of the induced electromagnetic field with the field of the source. Adequate numerical modeling must be based on appropriate calculation procedures based on numerical methods. The article substantiates the need to use numerical methods for calculation analysis, which allow creating calculation schemes closer to reality to a greater extent compared to the case of using analytical approaches and methods. The most effective numerical method is the finite element method, which allows the analysis of the non-stationary electromagnetic field and deformation within the same calculation scheme. In this case, within the framework of the finite element method, iterative schemes can be created that allow taking into account nonlinear effects. Here, nonlinear effects can be caused by the dependence of the mechanical and electrophysical properties of the material on temperature, the plastic nature of the deformation, as well as the need to account for contact phenomena. The results of modeling the propagation of the electromagnetic field of a single-turn inductor are presented.
Procedimiento - Registro de investigación interdiscipliar
Authors:   Universidad Científica del Sur
Published: November 2024

Procedimiento de registro de investigación interdisciplinar. Versión 1.0 (2024). Vigente
Performance Evaluation for Positive Displacement Motors by Combining Fluid-Structure Interaction Simulations and Experiments
Authors: Kuang Yuchun , Zhou Jingpei
Published: November 2024

The aim of this study is to propose a method for evaluating the performance of positive displacement motors (PDMs) from the perspective of robustness and energy conversion efficiency. Monitoring contact force and leakage is challenging when a steel rotor driven by liquid undergoes planetary motion within the rubber lining of the stator. A 3D model with a nominal diameter of 172 mm is established, along with a flow field of the same outer diameter as the stator. The constitutive parameters are determined according to the two-parameter Mooney-Rivlin model. After merging the overlapping nodes of the rubber lining and steel housing, the degrees of freedom are constrained from the exterior of the stator. Four-step loads are applied in ascending order. The average difference in overall efficiency between the experimental results and the simulation of the same model PDM is 1.58%. The sequential simulations include three sets of nine variables: lead (800 mm, 914.4 mm, 1200 mm), interference fit (0.1 mm, 0.2 mm, 0.3 mm), and rubber hardness (70 HA, 80 HA, 85 HA). Contact force differentials on each sealing band are calculated before and after stable operation. The reliability and stability of the cavities are assessed using the mean and variance of the force differentials. Efficiencies after each load stabilization are calculated to compare performance. For loads other than 200 N·m, the overall efficiency of the PDM with the optimized parameter combination increased by 2.98%, 0.27%, and 2.32%, respectively. Finally, this parameter combination is applied to a curved profile PDM. For loads other than 200 N·m, the overall efficiency increased by 3.22%, 0.89%, and 5.14%. This method, which combines the fluid-structure interaction (FSI) with an analysis of robustness and efficiencies, can be used to analyze the strengths and weaknesses of different parameter PDMs and to assess the performance of different profile motors.