bluuebunny/crossref_metadata_2025 huggingface dataset:
To Study and Determine the Role of Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy in Corneal and Conjunctival Tumors
Authors: Janssens Katleen , Mertens Michelle , Lauwers Noémie , de Keizer Rob J. W. , Mathysen Danny G. P. , De Groot Veva
Published: December 2016

Purpose. To analyze and describe corneal and conjunctival tumor thickness and internal characteristics and extension in depth and size and shape measured by two noninvasive techniques, anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Design. Systematic review. Methods. This systematic review is based on a comprehensive search of 4 databases (Medline, Embase, Web of Science, and Cochrane Library). Articles published between January 1, 1999, and December 31, 2015, were included. We searched for articles using the following search terms in various combinations: “optical coherence tomography”, “ultrasound biomicroscopy”, “corneal neoplasm”, “conjunctival neoplasm”, “eye”, “tumor” and “anterior segment tumors”. Inclusion criteria were as follows: UBM and/or AS-OCT was used; the study included corneal or conjunctival tumors; and the article was published in English, French, Dutch, or German. Results. There were 14 sources selected. Discussion. Several studies on the quality of AS-OCT and UBM show that these imaging techniques provide useful information about the internal features, extension, size, and shape of tumors. Yet there is no enough evidence on the advantages and disadvantages of UBM and AS-OCT in certain tumor types. Conclusion. More comparative studies are needed to investigate which imaging technique is most suitable for a certain tumor type.
Hysteresis and Soil Site Dependent Input and Hysteretic Energy Spectra for Far-Source Ground Motions
Authors: Mezgebo Mebrahtom Gebrekirstos , Lui Eric M.
Published: December 2016

Earthquake input energy spectra for four soil site classes, four hysteresis models, and five ductility levels are developed for far-source ground motion effect. These energy spectra are normalized by a quantity called velocity index (VI). The use of VI allows for the creation of dimensionless spectra and results in smaller coefficients of variation. Hysteretic energy spectra are then developed to address the demand aspect of an energy-based seismic design of structures with 5% critical damping and ductility that ranges from 2 to 5. The proposed input and hysteretic energy spectra are then compared with response spectra generated using nonlinear time history analyses of real ground motions and are found to produce reasonably good results over a relatively large period range.
Assessment of Groundwater Potential Based on Multicriteria Decision Making Model and Decision Tree Algorithms
Authors: Duan Huajie , Deng Zhengdong , Deng Feifan , Wang Daqing
Published: December 2016

Groundwater plays an important role in global climate change and satisfying human needs. In the study, RS (remote sensing) and GIS (geographic information system) were utilized to generate five thematic layers, lithology, lineament density, topology, slope, and river density considered as factors influencing the groundwater potential. Then, the multicriteria decision model (MCDM) was integrated with C5.0 and CART, respectively, to generate the decision tree with 80 surveyed tube wells divided into four classes on the basis of the yield. To test the precision of the decision tree algorithms, the 10-fold cross validation and kappa coefficient were adopted and the average kappa coefficient for C5.0 and CART was 90.45% and 85.09%, respectively. After applying the decision tree to the whole study area, four classes of groundwater potential zones were demarcated. According to the classification result, the four grades of groundwater potential zones, “very good,” “good,” “moderate,” and “poor,” occupy 4.61%, 8.58%, 26.59%, and 60.23%, respectively, with C5.0 algorithm, while occupying the percentages of 4.68%, 10.09%, 26.10%, and 59.13%, respectively, with CART algorithm. Therefore, we can draw the conclusion that C5.0 algorithm is more appropriate than CART for the groundwater potential zone prediction.
Prevalence and Characteristics of CAM Use among People Living with HIV and AIDS in Lebanon: Implications for Patient Care
Authors: Abou-Rizk Joana , Alameddine Mohamad , Naja Farah
Published: December 2016

This study aimed to assess the prevalence and determinants of Complementary and Alternative Medicine (CAM) use among People Living with HIV and AIDS (PLWHA) in Lebanon and to identify related issues that may affect patient care. A cross‐sectional survey design was used to interview 116 PLWHA in Beirut. The questionnaire addressed sociodemographic and disease characteristics as well as CAM use. The main outcome of the study was CAM use since diagnosis. Data analysis included descriptive statistics and logistic regression analyses. Overall, 46.6% of participants reported using one or more CAM therapies, with herbs and herbal products being the most commonly used (63%). A higher education level was associated with a 3‐fold increase in the odds of CAM use. Among users, 20% used CAM as alternative to conventional treatment, 48% were not aware of CAM‐drug interactions, 89% relied on nonhealth care sources for their choice of CAM, and 44% did not disclose CAM use to their physician. CAM use is prevalent among Lebanese PLWHA. Findings of this study highlighted the need to educate health care practitioners to have an open communication and a patient‐centered approach discussing CAM use during routine care and to enhance awareness of PLWHA on safe use of CAM.
Correlation Coefficient of Simplified Neutrosophic Sets for Bearing Fault Diagnosis
Authors: Shi Lilian
Published: December 2016

In order to process the vagueness in vibration fault diagnosis of rolling bearing, a new correlation coefficient of simplified neutrosophic sets (SNSs) is proposed. Vibration signals of rolling bearings are acquired by an acceleration sensor, and a morphological filter is used to reduce the noise effect. Wavelet packet is applied to decompose the vibration signals into eight subfrequency bands, and the eigenvectors associated with energy eigenvalue of each frequency are extracted for fault features. The SNSs of each fault types are established according to energy eigenvectors. Finally, a correlation coefficient of two SNSs is proposed to diagnose the bearing fault types. The experimental results show that the proposed method can effectively diagnose the bearing faults.
Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments
Authors: Poirier Andrée-Anne , Aubé Benoit , Côté Mélissa , Morin Nicolas , Di Paolo Thérèse , Soulet Denis
Published: December 2016

A diagnosis of Parkinson’s disease is classically established after the manifestation of motor symptoms such as rigidity, bradykinesia, and tremor. However, a growing body of evidence supports the hypothesis that nonmotor symptoms, especially gastrointestinal dysfunctions, could be considered as early biomarkers since they are ubiquitously found among confirmed patients and occur much earlier than their motor manifestations. According to Braak’s hypothesis, the disease is postulated to originate in the intestine and then spread to the brain via the vagus nerve, a phenomenon that would involve other neuronal types than the well-established dopaminergic population. It has therefore been proposed that peripheral nondopaminergic impairments might precede the alteration of dopaminergic neurons in the central nervous system and, ultimately, the emergence of motor symptoms. Considering the growing interest in the gut-brain axis in Parkinson’s disease, this review aims at providing a comprehensive picture of the multiple gastrointestinal features of the disease, along with the therapeutic approaches used to reduce their burden. Moreover, we highlight the importance of gastrointestinal symptoms with respect to the patients’ responses towards medical treatments and discuss the various possible adverse interactions that can potentially occur, which are still poorly understood.
Evaluating the Impact of Starter Fertilizer on Winter Canola Grown in Oklahoma
Authors: Abit M. Joy M. , Weathers Katlynn , Arnall D. Brian
Published: December 2016

Increased canola production costs and acres have driven Oklahoma (OK) farmers to ask more questions about their nutrient management recommendations in their production system. A study was conducted in 2011–2013 at Lahoma and Perkins, OK, to evaluate the effect of applying diammonium phosphate (DAP, 18-20-0:N-P-K) directly with seed on crop stand, grain yield, and grain quality of canola. In addition, the impact of proportion nitrogen (N) applied as a preplant and topdress was also evaluated. Diammonium phosphate was banded with the seed at planting at 0, 17, 34, 51, 67, and 84 kg DAP ha−1. Remaining N was applied as urea (46-0-0) either as split (40% preplant and 60% topdress) application or as topdress only. Stand count reduction of up to 71% was observed with seed-placed DAP. However, loss of stand did not impair grain yield due to canola’s ability to compensate for open areas via branching. Application of DAP of up to 84 kg ha−1 with seed may be possible; however, soil and climatic conditions should be considered when deciding how much DAP will be placed with seed. Moreover, when climatic conditions limit early season growth and favor late spring growth, applying all N at topdress (no preplant) tended to provide greater canola grain yield.
Participative Facility Planning for Obstetrical and Neonatal Care Processes: Beginning of Life Process
Authors: Reijula Jori , Karvonen Sauli , Petäjä Hanna , Reijula Kari , Lehtonen Liisa
Published: December 2016

Introduction.Old hospitals may promote inefficient patient care processes and safety. A new, functionally planned hospital presents a chance to create an environment that supports streamlined, patient-centered healthcare processes and adapts to users’ needs. This study depicts the phases of a facility planning project for pregnant women and newborn care processes (beginning of life process) at Turku University Hospital.Materials and Methods.Project design reports and meeting documents were utilized to assess the beginning of life process as well as the work processes of the Women’s and Children’s Hospital.Results.The main elements of the facility design (FD) project included rigorous preparation for the FD phase, functional planning throughout the FD process, and setting key values: (1) family-centered care, (2) Lean thinking and Lean tools as the framework for the FD process, (3) safety, and (4) cooperation.Conclusions.A well-prepared FD project with sufficient insight into functional planning, Lean thinking, and user-centricity seemed to facilitate the actual FD process. Although challenges occurred, the key values were not forgone and were successfully incorporated into the new hospital building.
Effects of Extracts from Tiaozhi Granule and Its Components on Expression of Scavenger Receptor Class B Type I
Authors: Yu Xiao , Zhao Xiao-Dong , Bao Rong-Qi , Yu Jia-Yu , Zhang Guo-Xing , Chen Jing-Wei
Published: December 2016

Sera from the rats with different drug treatments (atorvastatin, Tiaozhi granule, or its extracts) were collected. LO‐2 cells or HepG2 cells were pretreated with different sera as the following groups randomly: (1) blank control group, (2) positive control group (atorvastatin group), (3) Tiaozhi granule water extract groups, (4) Tiaozhi granule alcohol extract groups, and (5) alcohol extracts for each component: Pollen Typhae Angustifoliae, Curcuma longa L., and Rhizoma Alismatis. LO‐2 cells were cotransfected with plasmid carrying SR‐BI and pRL‐TK promoter genes. Promoter activity was measured by the luciferase reporter gene assay. The mRNA and protein expressions of SR‐BI were examined using real‐time PCR and western blot analyses. Our results show that promoter activity and mRNA and protein expression levels of the SR‐BI were significantly upregulated by Tiaozhi granules alcohol or water extracts in a dose‐dependent manner. Pollen Typhae Angustifoliae alcohol extract with a high dosage could also increase SR‐BI activity and expression, but not the extracts from Curcuma longa L. and Rhizoma Alismatis. Both Tiaozhi granule alcohol and water extracts can upregulate SR‐BI gene expression. Among the components, Pollen Typhae Angustifoliae are important for the regulatory effect coordinating with Curcuma longa L. and Rhizoma Alismatis.
Prediction Model of Coating Growth Rate for Varied Dip-Angle Spraying Based on Gaussian Sum Model
Authors: Zeng Yong , Zhang Yakun , He Junxue , Zhou Hai , Zhang Chunwei , Zheng Lei
Published: December 2016

In automatic spraying of spray painting robot, in order to solve the problems of coating growth rate modeling for varied dip-angle spraying technology, a prediction mode of coating growth rate using the Gaussian sum model is proposed. Based on the Gaussian sum model, a theoretical model for coating growth rate with varied dip-angle spraying is established by using the theory of differential geometry. The coating thickness of the sample points in the distribution range of the coating was obtained by making the experiment of varied dip-angle spraying. Based on the theoretical model, the nonlinear least square method is used to fit the coating thickness of the sample points and the parameter values of the theoretical model are calculated. By analyzing the variation law of the parameters with the spray dip-angle, the prediction model of coating growth rate for varied dip-angle spraying is established. Experiments have shown that the prediction model has good fitting precision; it can satisfy the real-time requirement with varied dip-angle spraying trajectory planning in the offline programming system.
Sacral Stress Fracture following the Bone Union of Lumbar Spondylolysis
Authors: Sasaji Tatsuro , Imaizumi Hideki , Takano Hiroyuki , Saitoh Hideo , Murakami Taishi , Kanabuchi Ryuichi , Sekiya Motohiko
Published: December 2016

While 22 articles have reported on sacral stress fractures, it is a rare injury and its etiology is not well known. We present the case of a 16-year-old male who presented with low back pain in 2015. He was a high school soccer player with a previous history of a bilateral L5 lumbar spondylolysis in 2014. The patient refrained from soccer and wore a brace for six months. Two months after restarting soccer, he again complained of low back pain. After 1 year, a lumbar spine computed tomography revealed the bone union of the spondylolysis. At his first visit to our hospital, his general and neurological conditions were normal and laboratory data were within the normal range. Sacral coronal magnetic resonance imaging (MRI) of the left sacral ala revealed an oblique lineal signal void surrounding bone marrow edema. Based on his symptoms, sports history, and MRI, he was diagnosed with a sacral stress fracture. He again refrained from soccer; his low back pain soon improved, and, after 1 year, the abnormal signal change had disappeared on sacral MRI. Recurrent low back pain case caused by a sacral stress fracture occurring after the bone union of lumbar spondylolysis is uncommon.
The Effect of Head Positioning and Head Tilting on the Incidence of Intraventricular Hemorrhage in Very Preterm Infants: A Systematic Review
Authors: de Bijl-Marcus Karen A. , Brouwer Annemieke J. , de Vries Linda S. , van Wezel-Meijler Gerda
Published: December 2016

Background: Despite advances in neonatal intensive care, germinal matrix-intraventricular hemorrhage (GMH-IVH) remains a frequent, serious complication of premature birth. Neutral head position and head tilting have been suggested to reduce the risk of GMH-IVH in preterm infants during the first 72 h of life. Objective: The aim of this study was to provide a systematic review of the effect of neutral head positioning and head tilting on the incidence of GMH-IVH in very preterm infants (gestational age ≤30 weeks). In addition, we reviewed their effect on cerebral hemodynamics and oxygenation. Methods: Literature was searched (June 2016) in the following electronic databases: CINAHL, Embase, Medline, SCOPUS, and several trial registers. Results: One underpowered trial studied the effect of head positioning on the incidence of GMH-IVH. This randomized controlled trial enrolled 48 preterm infants and found no effect on the occurrence of GMH-IVH. Three observational studies investigated the effect of head rotation and/or tilting on cerebral oxygenation in 68 preterm infants in total. Their results suggest that cerebral oxygenation is not significantly affected by changes in head positioning. The effect of head positioning and/or tilting on cerebral hemodynamics was described in 2 observational studies of 28 preterm infants and found no significant effect. Conclusions: There is insufficient evidence regarding the effect of head positioning and tilting on the incidence of GMH-IVH and cerebral hemodynamics and oxygenation in preterm infants. We recommend further research in this field, especially in extremely preterm and clinically unstable infants during the first postnatal days.
Efficacy of AdipoDren® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability
Authors: Ciccone Valerio , Monti Martina , Antonini Giulia , Mattoli Luisa , Burico Michela , Marini Francesca , Maidecchi Anna , Morbidelli Lucia
Published: December 2016

Lymphatic leakage can be seen as a detrimental phenomenon associated with fluid retention and deposition as well as gain of weight. Moreover, lymphatic dysfunction is associated with an inflammatory environment and can be a substrate for other health conditions. A number of treatments can ameliorate lymphatic vasculature: natural substances have been used as treatment options particularly suitable for their consolidated effectiveness and safety profile. Here we report the protective effect of AdipoDren®, an association of a series of plant-derived natural complexes, on lymphatic endothelium permeability promoted by interleukin-1 beta (IL-1β) and the associated molecular mechanisms. AdipoDren® demonstrated a protective effect on dermal lymphatic endothelial cell permeability increased by IL-1β. Reduced permeability was due to the maintenance of tight junctions and cell-cell localisation of occludin and zonula occludens-1 (ZO-1). Moreover, AdipoDren® reduced the expression of the inflammatory key element cyclooxygenase-2 (COX-2), while not altering the levels of endothelial and inducible nitric oxide synthases (eNOS and iNOS). The upregulation of antioxidant enzymatic systems (catalase and superoxide dismutase-1, SOD-1) and the downregulation of pro-oxidant markers (p22 phox subunit of NADPH oxidase) were also evident. In conclusion, AdipoDren® would be useful to ameliorate conditions of altered lymphatic vasculature and to support the physiological functionality of the lymphatic endothelium.
Skull Subsidence due to Periosteum Defect following Craniotomy in a Child
Authors: Arishima Hidetaka , Akazawa Ayumi , Kikuta Ken-ichiro
Published: December 2016

We report a case of a 7-year-old child with a cranial deformity secondary to a craniotomy for an intracranial hematoma. He suffered from an acute epidural hematoma with a lineal fracture of the right temporal bone following a severe head injury. A large question mark-shaped skin flap with the periosteum and temporal muscle was created for a decompressive craniectomy; however, neither the acute epidural hematoma nor brain swelling was severe, and we performed a small craniotomy compared with the skin flap without a decompressive craniectomy. Eighteen months after the operation, he complained of skull deformity with a mild depression of the forehead. Axial and 3-dimensional computed tomography showed thinness and subsidence of the frontoparietal bone around the replaced bone flap, corresponding to the skin flap with the periosteum defect. We suggest that the periosteum defect following creation of the skin flap during surgery prevented normal growth of the skull, which caused the thinness and subsidence of the frontoparietal bone. Preservation and cooptation of the periosteum should be performed during neurological surgeries in babies and children to prevent skull deformity.
Overexpression of TGF-β Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans
Authors: Müller-Deile Janina , Gellrich Finn , Schenk Heiko , Schroder Patricia , Nyström Jenny , Lorenzen Johan , Haller Hermann , Schiffer Mario
Published: December 2016

Background: TGF-β is known as an important stress factor of podocytes in glomerular diseases. Apart from activation of direct pro-apoptotic pathways we wanted to analyze micro-RNA (miRs) driven regulation of components involved in the integrity of the glomerular filtration barrier induced by TGF-β. Since miR-143-3p (miR-143) is described as a TGF-β inducible miR in other cell types, we examined this specific miR and its ability to induce glomerular pathology. Methods: We analyzed miR-143 expression in cultured human podocytes after stimulation with TGF-β. We also microinjected zebrafish eggs with a miR-143 mimic or with morpholinos specific for its targets syndecan and versican and compared phenotype and proteinuria development. Results: We detected a time dependent, TGF-β inducible expression of miR-143 in human podocytes. Targets of miR-143 relevant in glomerular biology are syndecans and versican, which are known components of the glycocalyx. We found that syndecan 1 and 4 were predominantly expressed in podocytes while syndecan 3 was largely expressed in glomerular endothelial cells. Versican could be detected in both cell types. After injection of a miR-143 mimic in zebrafish larvae, syndecan 3, 4 and versican were significantly downregulated. Moreover, miR-143 overexpression or versican knockdown by morpholino caused loss of plasma proteins, edema, podocyte effacement and endothelial damage. In contrast, knockdown of syndecan 3 and syndecan 4 had no effects on glomerular filtration barrier. Conclusion: Expression of versican and syndecan isoforms is indispensable for proper barrier function. Podocyte-derived miR-143 is a mediator for paracrine and autocrine cross talk between podocytes and glomerular endothelial cells and can alter expression of glomerular glycocalyx proteins.
The Vigabatrin Induced Retinal Toxicity is Associated with Photopic Exposure and Taurine Deficiency: An In Vivo Study
Authors: Tao Ye , Yang Jixue , Ma Zhao , Yan Zhongjun , Liu Ce , Ma Jianjie , Wang Yunqin , Yang Zhen , Huang Yi Fei
Published: December 2016

Background/Aims: Retinal toxicity is one of the most commonly discussed and concerning adverse effects of vigabatrin (VGB). The present study explored the relationship between the VGB elicited retinal toxicity, photopic exposure, and taurine deficiency, aiming at screening for risk factors to minimize the adverse effects of VGB. Methods: The effects of VGB on function and morphology of mouse retinas were examined via a series of in vivo tests, including electroretinography (ERG), Spectral domain optical coherence tomography (SD-OCT), and optokinetic testing. Moreover, VGB-treated mice were in addition treated with taurine to verify possible protective effects against retinal toxicity. Results: A close relationship between VGB induced retinal toxicity and light exposure was observed. The VGB-treated mice which were reared in darkness preserved better visual function and retinal architectures as verified by the optokinetic tests, OCT and ERG examinations. The retinal taurine level of the VBG-treated mice which were exposed to light were significantly lower than that of the VBG mice reared in darkness. Furthermore, several in vivo evidence provided by our research confirmed that the VGB induced morphological and functional impairments could be partially alleviated by taurine treatment. The present study showed the retinal toxicity of VGB by in vivo measurements. Conclusion: The VGB induced retinal toxicity is closely associated with photopic exposure and taurine deficiency. Patients who are taking VGB might benefit from minimization of light exposure and dietetic taurine supplements.
Smad3-mSin3A-HDAC1 Complex is Required for TGF-β1-Induced Transcriptional Inhibition of PPARγ in Mouse Cardiac Fibroblasts
Authors: Gong Kaizheng , Chen Mingxing , Li Rujun , He Yanghong , Zhu Huajiang , Yao Dan , Oparil Suzanne , Zhang Zhengang
Published: December 2016

Background: We have recently demonstrated that activated transforming growth factor-β (TGF-β) signaling suppresses myocardial peroxisome proliferator-activated receptor γ (PPARγ) expression in the pressure overloaded heart. In this study, we aim to further define the molecular mechanisms that underlie TGF-β-induced PPARγ transcriptional inhibition. Methods: Adult mouse cardiac fibroblasts were isolated and cultured. PPARγ promoter activity was measured by the dual-Luciferase reporter assay. Interactions between transcription factors and the target gene were identified. Results: In cultured cardiac fibroblasts transfected with a plasmid containing a human PPARγ promoter, co-transfection of Smad3 and Smad4, but not Smad2, plasmids significantly enhanced TGF-β1-induced inhibition of PPARγ promoter activity. Promoter deletion analysis and site-directed mutagenesis assays defined two Smad binding elements on the promoter of the PPARγ gene. Utilizing chromatin immunoprecipitation analysis and DNA-affinity precipitation methods, we demonstrated that the transcriptional regulatory complex consisting of Smad3, mSin3A and HDAC1 bound to the promoter of the PPARγ gene in cardiac fibroblasts in response to TGF-β1 stimulation. Either silencing endogenous mSin3A expression by Lentivirus-mediated transduction of mSin3A shRNA or pretreatment with the specific HDAC1 inhibitor MS-275 effectively attenuated TGF-β-induced transcriptional suppression of PPARγ. Conclusion: These results suggest that TGF-β1-induced inhibition of PPARγ transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3, mSin3A and HDAC1 at the PPARγ promoter.
miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation
Authors: Chen Tianji , Zhou Qiyuan , Tang Haiyang , Bozkanat Melike , Yuan Jason X.‐J. , Raj J. Usha , Zhou Guofei
Published: December 2016

Background

Previously we found that smooth muscle cell (
SMC
)‐specific knockout of miR‐17~92 attenuates hypoxia‐induced pulmonary hypertension. However, the mechanism underlying miR‐17~92‐mediated pulmonary artery
SMC
(
PASMC
) proliferation remains unclear. We sought to investigate whether miR‐17~92 regulates hypoxia‐inducible factor (
HIF
) activity and
PASMC
proliferation via prolyl hydroxylases (
PHD
s).

Methods and Results

We show that hypoxic sm‐17~92
−/−
mice have decreased hematocrit, red blood cell counts, and hemoglobin contents. The sm‐17~92
−/−
mouse lungs express decreased
mRNA
levels of
HIF
targets and increased levels of
PHD
2. miR‐17~92 inhibitors suppress hypoxia‐induced levels of
HIF
1α,
VEGF
, Glut1,
HK
2, and
PDK
1 but not
HIF
2α in vitro in
PASMC
. Overexpression of miR‐17 in
PASMC
represses
PHD
2 expression, whereas miR‐17/20a inhibitors induce
PHD
2 expression. The 3′‐
UTR
of
PHD
2 contains a functional miR‐17/20a seed sequence. Silencing of
PHD
2 induces
HIF
1α and
PCNA
protein levels, whereas overexpression of
PHD
2 decreases
HIF
1α and cell proliferation.
SMC
‐specific knockout of
PHD
2 enhances hypoxia‐induced vascular remodeling and exacerbates established pulmonary hypertension in mice.
PHD
2 activator R59949 reverses vessel remodeling in existing hypertensive mice.
PHD
s are dysregulated in
PASMC
isolated from pulmonary arterial hypertension patients.

Conclusions

Our results suggest that
PHD
2 is a direct target of miR‐17/20a and that miR‐17~92 contributes to
PASMC
proliferation and polycythemia by suppression of
PHD
2 and induction of
HIF
1α.
R. Buckminster Fuller, the Expo ’67 Pavilion and the Atoms for Peace Program
Authors: Dalvesco Rebecca
Published: December 2016

Since the end of World War II, the U.S. government has embraced the rhetoric of the peaceful use of the atom. Following the government’s lead, architect-designer-philosopher Richard Buckminster Fuller espoused similar ideas. Like U.S. President Lyndon Johnson and other “atoms for peace” enthusiasts, Fuller thought that the revolution then occurring in architecture was an outgrowth of the peaceful atom. And, like Johnson, Fuller believed that technology based on the atom did not just favor Americans but could be applied for the benefit of all humanity. Fuller thought atomic technology could help extend humankind’s knowledge base and thus be applied to develop better architecture. This article explains how Fuller, like politicians of the time, believed that the potential for fearful products of destruction—of war and its weaponry—could be applied for peacetime applications, particularly when designing his geodesic dome, including his Expo ’67 pavilion.
Art, Science, Technology: Six Exhibitions 1966–1998
Authors: Popper Frank
Published: December 2016

From the late 1960s until the end of the twentieth century, the author organized, or helped organize, six exhibitions throughout Europe that saw artists integrate and alter the collective destinies of science, art and technology. The works of art presented at these exhibitions: KunstLichtKunst at the Stedelijk Van Abbe Museum in Eindhoven; the Lumière et Mouvement exhibition at the Musée d’Art Moderne de la Ville de Paris; Cinétisme, Spectacle, Environnement, held at the Mobile theater of the Maison de la Culture in Grenoble; Interventions and Environments in the Streets of Paris and in Its Suburbs and Electra at the Museum of Modern Art of the City of Paris; and the Virtual Art show in Boulogne-Billancourt in 1998, did more than just lay a formal and theoretical foundation for new media art to follow—they challenged the perceptions of both the spectator of the art as well as other artists working in this area. This article chronicles the aesthetic and societal ramifications, particularly within the artistic community, that the works in these exhibitions created.
DreamArchitectonics: An Interactive Audiovisual Installation
Authors: Dufour Frank , Dufour Lee
Published: December 2016

This article presents the processes that guided the production of the interactive artwork DreamArchitectonics, attempting to render perceivable the altered experience of time characteristic of the dream-state. This project originated with the observation of dream reports that were revealed, across a broad variety of contents, to be relatively invariant in form, with this form appearing to function as a mnemonic artifact allowing the dreamer to actually remember dreams. The details of the representational process applied to oneiric time and manifested in these artifacts have been identified to resonate meaningfully with poetic expression, especially in its relationship to the sensation of movement. DreamArchitectonics aims at producing the context for an experiential synthesis of this intuition and acting as the generator of phenomenological data in a disposition that the authors envision as the most fruitful for collaboration between arts and sciences.
Digital Art: The ’60s to the ’80s, from the Point of View of an Observa

c

tor
Authors: Couchot Edmond
Published: December 2016

In this short biography, Edmond Couchot tells how, after having attempted a plastic-art synthesis between gestural painting and lumino-kineticism, he became interested in cybernetics and visual arts and the participation of the spectator in aesthetic perception. Then we learn how, in the early 1980s, he took part in the creation of a new degree course in art and technology of the image at the University of Paris-VIII.
Ylem: Serving Artists Using Science and Technology, 1981–2009
Authors: Reagan Trudy Myrrh
Published: December 2016

YLEM: Artists Using Science and Technology, a nonprofit group in the San Francisco Bay Area, was active from 1981 to 2009, publishing the YLEM Newsletter (later, the YLEM Journal). In the 1990s, it published the Directory of Artists Using Science and Technology, illustrated with members’ work, and established its website, < www.ylem.org >. YLEM’s public Forums introduced artists to science, scientists to art and the general public to new artistic and technological expression. It organized field trips to laboratories, industrial sites and artists’ studios and mounted exhibitions of members’ work. Members’ friendships mutually encouraged their work in this new arena.
@Caltech: Art, Science and Technology, 1969–1971
Authors: Nowlin Stephen
Published: December 2016

In 1969, the vision of a handful of professors at California Institute of Technology resulted in an initiative to bring artists and scientists together to “see what happens.” The experiment embodied insurgent notions of that era—ideas that would once again become manifest a generation later in the young 21st century’s art-science fusion. Out of this venture came hints of new visual vocabularies and ways of making, as well as an awareness of fault lines between the two cultures. To one young student who found his way into it, the Caltech experience became a transforming moment.
Art-Science Interactions in the Destruction of an Archive: The after | image Project
Authors: Reichelt-Brushett Amanda , Cooke Grayson
Published: December 2016

The after | image project is an inquiry into notions of material memory and forgetting and their intersection with archival preservation and dissolution. The project involves the intentional destruction by the authors of a photographic archive using various acids, chemical compounds and oxidizing agents; this destruction is recorded using time-lapse macrophotography. The authors thus challenge the often-intense human desire to retain a record of the past, a “hard copy” of memory. In the process of destroying the negative film, the authors create something new and by doing so are afforded the opportunity to revisit memories and their materialization within photographic media. In theoretical terms, the article focuses on the notion of “repeatability” as a trope that foregrounds the intertwining of artistic and scientific approaches. Collaborations like after | image facilitate the development of knowledge that is underpinned by both aesthetic qualities and experimental design and is thus both artistically and scientifically “true” at the same time.
Art, Aliens and the Machine
Authors: Smith G.W.
Published: December 2016

With the assumption that the extraordinary discoveries being made in planetary science will soon trigger a conviction of the likelihood of contact with sentient extraterrestrial beings—and with the further realization that such beings may well depend upon our visual arts as their primary point of reference in respect to our own species—this short paper uses an imaginative approach to develop some corollary ideas, and, in addition, to throw a spotlight on pioneering “systems art” theorist and visionary cosmic citizen Jack Burnham.
The Living Canvas: Interactive Chloroplasts
Authors: Dolinsky Margaret , Hangarter Roger P.
Published: December 2016

The Living Canvas is a science/art/educational exhibit of artwork created by using the positioning of chloroplasts in leaf cells as an artistic medium and using light to control that medium. The work reveals the process of chloroplast movements as they occur in leaf cells and how those subcellular changes affect the optical properties of whole leaves to maximize photosynthesis. The works are designed to stimulate a sense of intrigue and awe to enhance the viewers’ awareness of plant life and their relationships with plants in their environment.
Refractive Fingerprints of Lenses: Explorations in Light Transformations
Authors: Pinkel Sheila
Published: December 2016

Searching for an apt visual metaphor for multiculturalism to form the cover of an exhibition catalogue in 2011, the author scanned a Canon lens using a flatbed scanner and found that the whole visible color spectrum was included in the resulting image. This serendipitous discovery led to an ongoing research project on the unique refractions of all manner of lenses.
Caryatids and Promiscuity
Authors: Davey Moyra
Published: December 2016

In “Caryatids & Promiscuity,” Moyra Davey reflects on the ebb and flow of photographic discourse and the impact of its shifting critical reception over three decades of her life and career as an artist, filmmaker, and writer.
The Black Mirror
Authors: Baker George
Published: December 2016

From his films Empire (2002) and Anticultural Positions (2009) to a variety of his modes of drawing, a singular concentration on the photographic negative can be found throughout Paul Sietsema's artistic practice. Rather than grounding a medium, Baker argues, the location of photography's logic in the negative preserves the photograph as a space of reversal and inversion, a deep and powerful force of negation rather than a servant of the real. To return, as Sietsema does, to this history and to such processes now, after they have run their course, seems to insist on the negative as a kind of literal afterimage, and also, potentially, as an open image, considering how the negative transmutes the density of the world into transparency, inhabiting a space between the object and the image, the middle point between camera and print, a “medium” in the true but irremediably hybrid sense of the word.
The Qinghua “Jinteng” Manuscript: What it Does Not Tell Us about the Duke of Zhou
Authors: Ribbing Gren Magnus
Published: December 2016

This study suggests that the so-called “Jinteng” manuscript held by Qinghua University should be read independently of its received counterpart. When read on its own terms, the manuscript provides a straightforward account of rituals surrounding the Duke of Zhou’s ascension to the throne after the demise of King Wu. As such it represents a continuation of King Wu’s abdication in favor of his meritorious brother, as recorded in the Yi Zhou shu. Read in this light, the fourth century BCE manuscript provides further evidence for the prominence of abdication doctrines during the Warring States period, an intellectual tradition that was deemed subversive in the early empire and became gradually obliterated over the course of the Qin-Han dynasties. 

Cet article propose de lire le manuscrit dit “Jinteng” conservé à l’université Qinghua indépendamment des textes reçus qui lui correspondent. Considéré par lui-même, le manuscrit offre une relation claire des rituels ayant entouré l’accession au trône du duc de Zhou après la mort du roi Wu. De ce fait, il représente le prolongement de l’abdication du roi Wu en faveur de son vertueux frère telle qu’elle est relatée dans le Yi Zhou shu. Considéré sous cet angle, ce manuscrit du IVe siècle avant notre ère offre de nouveaux arguments en faveur de l’importance des doctrines sur l’abdication à l’époque des Royaumes Combattants, alors que cette tradition intellectuelle était considérée comme subversive au début de l’empire et qu’elle est progressivement tombée dans l’oubli sous les Qin et les Han.
The southernmost fossil record of Squamates
Authors: Albino Adriana , Brizuela Santiago , Vizcaíno Sergio
Published: December 2016

Squamates form a substantial part of the present-day South American herpetofauna, and their fossils constitute an indispensable evidence for understanding the origin and evolution of the main taxa. Squamates are relatively common in Miocene localities of Patagonia, especially in levels of the late early Miocene Santa Cruz Formation. In this contribution, remains of the three species of the extinct iguanidErichosaurusAmeghino 1899 (E. diminutus,E. bombimaxillaandE. debilis) are redescribed, and new squamate specimens are reported for first time. The genusErichosaurusis considered invalid.Erichosaurus debilis,E. diminutusand a new specimen are recognized as indeterminate species of the extant polichrotinePristidactylus, whereasE. bombimaxillaremains as an indeterminate iguanid. Snakes are represented by an indeterminate colubrid. All these specimens, together with a tupinambine teiid previously described for the same formation, represent the southernmost fossil record of squamates in South America and indicate the occurrence of the iguanidPristidactylus, the teiidTupinambisand the colubrid snakes south to their present distribution as back as during the early Miocene.
On Vietnamese representatives of the ant spider genus Heradion (Araneae: Zodariidae)
Authors: CHAMI-KRANON THANAPHUM , ONO HIROTSUGU
Published: December 2016

A new species of the genus Heradion Dankittipakul & Jocqué, H. intermedium spec. nov., is described based on specimens collected in southern Vietnam. Heradion paradiseum (Ono) comb. nov., H. flammeum (Ono) comb. nov. and H. momoinum (Ono) comb. nov. are here transferred from Mallinella Strand. All the Heradion species treated in the present study belong to the H. naiadis-group which comprises six nominal species known from evergreen hill forests of Thailand and Vietnam. A map showing distribution of the species-group and a key to species of the genus Heradion of Vietnam are provided.
A new species of Pseudocoutierea Holthuis from the Caribbean coast of Panama (Crustacea, Decapoda, Palaemonidae), with a key to the genus
Authors: DE GRAVE S.
Published: December 2016

A new species of pontoniid shrimp , Pseudocoutie rea dotae sp. nov. is described from Bocas Province (Caribbe an coast of Panama ), on the basis o f a single specimen encountered on a whip-coral , Stichopathes lutken i . The new species is closely related to the eas tern Atlantic species , P. wirtzi , with which it shares th e presence of a post-hepatic tubercl e. A key to the genus is presen ted.
A new Buchananiella Reuter (Hemiptera: Anthocoridae) from Indochina and the Malay Peninsula, with a note on B. crassicornis Carayon
Authors: YAMADA KAZUTAKA , HIROWATARI TOSHIYA
Published: December 2016

A new flower bug, Buchananiella atrata, is described based on recently collected specimens from Indochina and the Malay Peninsula; and Buchananiella crassicornis Carayon is recorded from Thailand for the first time. Buchananiella atrata Yamada and Hirowatari, new species, is closely allied to the latter species, from which it is separable by rostral segment III being blackish brown with pale yellow apex, the entirely blackish brown femur, and the paramere being apically modified into a acute projection and a swollen portion.
A new species of Rhynchocalamus (Reptilia: Serpentes: Colubridae) from Turkey
Authors: OLGUN KURTULUÔ , AVCI AZIZ , ILGAZ ÇETN , ÜZÜM NAZAN , YILMAZ CAN
Published: December 2016

A snake species new to science, Rhynchocalamus barani n. sp., is described from Turkey. It differs from other Rhynchocalamus species in having higher numbers of dorsalia (17 instead of 15) and lower number of ventralia (163–173 instead of 180–240) and upper labials in contact with eye (1 instead of 2) and by a characteristic color-pattern of the body.
Taxonomic notes on the genera Brypoctia Schoorl, 1990 and Schreiteriana Fletcher & Nye, 1982 (Lepidoptera, Cossidae)
Authors: PENCO FERNANDO C. , YAKOVLEV ROMAN V. , WITT THOMAS J.
Published: December 2016

Currently, the Cossidae of South America are rather poorly studied. Data on the distribution and taxonomy of Neotropical carpenter moths are lacking. An exception is the clarification of the taxonomic position of the genus Miacora Dyar, 1905 (Yakovlev 2014), Neotropical Cossidae checklist (Donahue 1995), and a preliminary list of Cossidae  of Argentina (Penco & Yakovlev 2015). The majority of Neotropical Cossidae genera have not been studied and the taxonomic position of some genera remains completely unresolved. Additionally, images of genitalia of the Neotropical genera have not been published, including the genera Brypoctia Schoorl, 1990 and Schreiteriana Fletcher & Nye, 1982 (Cossidae: Zeuzerinae). The taxonomic position of the second genus was questioned by Schoorl (1990).
Galeus corriganae sp. nov., a new species of deepwater catshark (Carcharhiniformes: Pentanchidae) from Papua New Guinea
Authors: WHITE WILLIAM T. , MANA RALPH R. , NAYLOR GAVIN J.P.
Published: December 2016

A new species of catshark, provisionally placed in the genus Galeus, is described from Papua New Guinea based on 7 specimens collected during recent deepwater surveys of the region. The new species, Galeus corriganae, is closest to G. priapus from New Caledonia and G. gracilis from northwestern Australia but differs in several morphological characters. A reclassification of the catshark groups is required to revise the familial and generic arrangement of the group.
Catalogue of the Teratomyzidae (Diptera, Opomyzoidea) of the World
Authors: RODRIGUES J.P.V. , PEREIRA-COLAVITE A. , MELLO R.L.
Published: December 2016

A catalogue of Teratomyzidae of the world is presented comprising 23 described species in seven genera. Geographic records for nine undescribed species are also listed. All valid names and synonyms are presented, totaling 34 names. All references known to us from the taxonomic and biological literature, including information about name, author, year of publication, page number, type genus, type species, type locality and references are given to the categories of family, genus and species. Camur willii McAlpine has its distributional record enlarged to Paraná (Brazil).
Description of the tadpoles of Proceratophrys cristiceps (Anura: Cycloramphidae, Odontophrynini)
Authors: DA SILVA VIEIRA WASHINGTON LUIZ , DA SILVA VIEIRA KLEBER , SANTANA GINDOMAR GOMES
Published: December 2016

The tadpoles of Proceratophrys cristiceps (Müller, 1884) are described based on specimens collected in a temporary pool at the Estação Experimental de São João do Cariri, in the municipality of São João do Cariri, Paraíba State, in NE Brazil. Tadpoles in stage 39 had a total length of 30.31 mm, a body length of 12.45 mm (corresponding to 41.07% of their total length), were ovoid shaped in dorsal view, slightly depressed in lateral view, and with a dental formula 2(2)/3(1). The morphological characteristics of the tadpole P. cristiceps were compared with other tadpoles of four species belonging to the Proceratophrys bigibbosa group.
Social Issues in Management as a Distinct Field: Corporate Social Responsibility and Performance
Authors: Wood Donna J. , Logsdon Jeanne M.
Published: December 2016

This article focuses on the question of whether Social Issues in Management (SIM) is a “field” and, if so, what kind, emphasizing specifically the recent literature on corporate social responsibility and performance (CSR/CSP). Fields are defined in part by coherent bodies of knowledge that serve as guideposts for current research, and so the authors construct a simple model of CSR/CSP scholarship, illustrating the relevant categories with representative publications. The authors conclude that SIM is a “low-paradigm” field but is not recognized or accepted as a field by many scholars who write about CSR/CSP from “outside” the field. This analysis points to the need for SIM scholars to continue to integrate useful ideas from other fields, and also to critique the work of scholars who address “failings” or “gaps” in SIM research without appropriately dealing with the existing SIM literature. The article concludes with some ideas for sustaining the institutional legitimacy of SIM and for challenging those who would “reinvent” a field with a long and fruitful history, including paying careful attention to journal review processes and the content of publications in prominent journals.