bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis And Multifaceted Pharmacological Activity of Novel Quinazoline NHE-1 Inhibitors
Authors: Spasov Alexander , Ozerov Alexander , Vassiliev Pavel , Kosolapov Vadim , Gurova Natalia , Babkov Denis , Sirotenko Viktor , Taran Alena , Litvinov Roman , Borisov Alexander , Klochkov Vladlen , Merezhkina Darya , Miroshnikov Mikhail , Ovsyankina Natalia
Published: September 2021

The Na+/H+ exchanger isoform 1 (NHE-1) attracts ongoing attention as a validated drug target for the management of cardiovascular and ocular diseases owing to cytoprotective, anti-ischemic and anti-inflammatory properties of NHE-1 inhibitors. Herein we report novel NHE-1 inhibitors realized via functionalization of N1-alkyl quinazoline-2,4(1H,3H)-dione and quinazoline-4(3H)-one with N-acylguanidine or 3-acyl(5-amino-1,2,4-triazole) side chain. Lead compounds show activity in a nanomolar range. Their pharmacophoric features were elucidated with neural network modeling. Several compounds combine NHE-1 inhibition with antiplatelet activity. Compound 6b reduces intraocular pressure in rats and effectively inhibits the formation of glycated proteins. Compounds 3e and 3i inhibit pro-inflammatory activation of murine macrophages, LPS-induced interleukin-6 secretion and also exhibit antidepressant activity similar to amiloride. Hence, novel compounds represent an interesting starting point for the development of agents against cardiovascular diseases, thrombotic events, excessive inflammation, long-term diabetic complications and glaucoma.
Development of a Lifestyle Intervention Program for Overweight or Obese Preconception, Pregnant and Postnatal Women: a Qualitative Study
Authors: Ku Chee Wai , Leow Shu Hui , Ong Lay See , Erwin Christina , Ong Isabella , Ng Xiang Wen , Tan Jacinth JX , Yap Fabian , Chan Jerry Kok Yen , Loy See Ling
Published: September 2021

The time period before, during and after pregnancy represents a unique opportunity for interventions to cultivate sustained healthy lifestyle behaviors to improve the metabolic health of mothers and their offspring. However, the success of a lifestyle intervention is dependent on uptake and continued compliance. To identify enablers and barriers towards engagement with a lifestyle intervention, thematic analysis of 15 in-depth interviews with overweight or obese women in the preconception, pregnancy or postpartum periods was undertaken, using the integrated–Promoting Action on Research Implementation in Health Services (i-PARIHS) framework as a guide to systematically chart factors influencing adoption of a novel lifestyle intervention. Barrier factors include time constraints, poor baseline knowledge, family culture, food accessibility, and lack of relevant data sources. Enabling factors were motivation to be healthy for themselves and their offspring, family and social support, a holistic delivery platform providing desired information delivered at appropriate times, regular feedback, goal setting, and nudges. From the findings of this study, we propose components of an idealized lifestyle intervention including (i) taking a holistic life-course approach to education, (ii) using mobile health platforms to reduce barriers, provide personalized feedback and promote goal-setting, and (iii) health nudges to cultivate sustained lifestyle habits.
Automated Diagnosis of Cervical Intraepithelial Neoplasia in Histology Images via Deep Learning
Authors: Cho Bum-Joo , Kim Jeong Won , Park Jungkap , Kwon Gui Young , Hong Mineui , Jang Si-Hyong , Bang Heejin , Kim Gilhyang , Park Sung Taek
Published: September 2021

Artificial intelligence has enabled the automated diagnosis of several cancer types. We aimed to develop and validate deep learning models that automatically classify cervical intraepithelial neoplasia (CIN) based on histological images. Microscopic images of CIN3, CIN2, CIN1, and non-neoplasm were obtained. The performances of two pre-trained convolutional neural network (CNN) models adopting DenseNet-161 and EfficientNet-B7 architectures were evaluated and compared with those of pathologists. The dataset comprised 1,106 images from 588 patients; images of 10% of patients were included in the test dataset. The mean accuracies for the 4-class classification were 88.5% (95% confidence interval [CI], 86.3–90.6%) by DenseNet-161 and 89.5% (95% CI, 83.3–95.7%) by EfficientNet-B7, which were similar to human performance (93.2% and 89.7%). The mean per-class area under the receiver operating characteristic curve values by EfficientNet-B7 were 0.996, 0.990, and 0.971 in the non-neoplasm, CIN3, CIN1 groups, respectively. The class activation map detected the diagnostic area for CIN lesions. In the 3-class classification of CIN2 and CIN3 as one group, the mean accuracies of DenseNet-161 and EfficientNet-B7 increased to 91.4% (95% CI, 88.8–94.0%) and 92.6% (95% CI, 90.4–94.9%), respectively. CNN-based deep learning is a promising tool for diagnosing CIN lesions on digital histological images.
Generalized partially functional linear model
Authors: Xiao Weiwei , Wang Yixuan , Liu Haiyan
Published: September 2021

In this paper, we propose a generalized functional linear regression model with scalar and functional multiple predictors. We develop maximum likelihood estimators for the regression coefficients. For the functional predictors, we adopt the method of functional principal component analysis to reduce their dimensions. We then propose the generalized auto-covariance operator, based on which an appropriate measure quantifies the difference between the estimators and their true values is established. The asymptotic joint distribution of estimated regression functions is proved. For the scalar predictors, we establish a distance between the estimated value and the true value, and prove the asymptotic property of the estimated regression coefficients. Extensive simulation experiment results are consistent with the theoretical result. Finally, two application examples of the model are given. One is sleep quality study where we studied the effects of heart rate, percentage of sleep time on total sleep in bed, wake after sleep onset and number of wakening during the night on sleep quality in 22 healthy people. The other one is mortality rate where we studied the effects of air quality index, temperature, relative humidity , GDP per capita and the number of beds per thousand people on the mortality rate across 80 major cities in China.
Antibody response induced by the boost overdose during COVID-19 heterologous prime-boost vaccination strategy: A four-case study
Authors: Raposo Francisco , Lippi Giuseppe
Published: September 2021

Objectives

The main purpose of this study was to evaluate the anti-SARS-CoV-2 RBD Ig G antibody response in BNT162b2 vaccine recipients who erroneously received vaccine overdose.
Methods

Measurement of antibody levels at different time-points was performed to define the dynamics of immunization after a wrongly vaccination schedule. Three recipients had no previous evidence of infection and received the first shot of Oxford/AstraZeneca before the Pfizer/BioNTech vaccine. Another patient, formerly infected by SARS-CoV-2, received one shot of BNT162b2 vaccine.
Results

At day 6 after the second vaccine dose the serum increase of anti-SARS-CoV-2 RBD Ig G antibodies was analogous for the three SARS-CoV-2 naïve recipients. At 14 days the antibody level increased and reached a peak, though displaying a different pattern among the three recipients. At 21 days the serum antibody level started to decrease from its maximum value. The data for the previously infected recipient were in agreement with values found in COVID-19 positive receivers. Thus, after the single prime-dose of vaccine, the elicited antibody response was similar to prime-boost vaccination in naïve recipients.
Conclusions

This study confirms the efficiency of the BNT162b vaccine in eliciting a sustained antibody response as heterologous boost-vaccine in previously Oxford/AstraZeneca vaccinated recipients, as well as, prime-vaccine in COVID-19 infected receivers. Importantly, the humoral immunity response of recipients was not proportional to the vaccine overdose. Nonetheless, we cannot portray a univocal effect of vaccine overdose concerning anti-SARS-CoV-2 antibody response because the values found especially in the three SARS-CoV-2 naïve subjects were highly heterogeneous.
Magnitudes and Determinants of Antenatal Care Utilization among Pregnant Women in East Africa: Evidence from Demographic and Health Surveys (DHS) from 2010 to 2018
Authors: Raru Temam Beshir , Negash Belay , Shalmenu Biruk , Birhanu Addisu , Demissie Lemma , Bahiru Nebiyu , Deressa Alemayehu , Roba Gebiso , Alemu Addisu , Yuya Mohammed , Mamo Galana
Published: September 2021

Introduction: The use of antenatal care (ANC) plays a major role in minimizing maternal and child mortality through effective and appropriate screening, preventive, or treatment intervention. Despite the fact that almost all of the pregnancy-related mortalities are largely preventable through adequate use of ANC, Sub-Saharan Africa (SSA) particularly East African Countries continues to share the largest share of global maternal, and newborn mortality. Therefore, this study aimed to estimate the overall magnitude and determinants of ANC utilization in the 11 East Africa Countries from 2010 to 2018 using recent Demographic and Health Surveys (DHS)Methods: A secondary data analysis was done based on DHS from 2010 to 2018 in the 11 East African Countries. A total weighted sample of 89,991 women who gave birth in the 5 years preceding each country’s DHS survey were included in this study. Data processing and analysis were performed using STATA 15 software. Multilevel mixed effect logistic regression model was fitted. Model comparison was done based on Akaike and Bayesian Information Criteria (AIC and BIC). Variables with a p-value≤0.05 were declared as significant determinants of ANC utilization.Results: The magnitude of ANC utilization in East African Countries was 53.03% (95% CI: 52.70, 53.35) with the highest ANC utilization in Kenya (57.64%) and the lowest ANC utilization in Comoros (48.99%). In the multivariable multilevel logistic regression model; age 20-24 (Adjusted Odds Ratio (AOR) = 1.25; 95% CI; 1.17-1.34), 25-29 AOR = 1.47; 95% CI; 1.37-1.58), 30-34 (AOR = 1.58; 95% CI; 1.47-1.71), 35-39 (AOR = 1.63; 95% CI; 1.50-1.77), 40-44 (AOR = 1.64; 95% CI; 1.49-1.81), 45-49 (AOR = 1.71; 95% CI; 1.51-1.93), primary education (AOR = 1.24; 95% CI; 1.18-1.31), richest wealth index (AOR = 1.57; 95% CI; 1.47-1.67), being in rural resident (AOR = 0.93; 95% CI; 0.88,0.98), have media exposure (AOR = 1.11; 95% CI; 1.07-1.15), and being a Zimbabwe resident (AOR = 2.87; 95% CI; 2.55-3.23) were among factors that are significantly associated with ANC utilization.Conclusion: ANC utilization was low in the East Africa countries. Age, women education, wealth index, birth order, residence, media exposure and living countries were major determinants of ANC utilization. It would be useful to increase financial support strategies that enables mothers from poor households to use health services will be advantageous. To increase women’s understanding of the significance of ANC utilization, health education targeting mothers with no education is very crucial.
Effect of electronic banking on financial performance of deposit money banks in Nigeria
Authors: Madugba Joseph , Egbide Ben-Caleb , Wozuru Jossy Dike , Toby Agburuga Uche , Onyebuchi Chibunna Onwubiko
Published: September 2021

The impact of technology on commerce cannot be denied, especially in relation to trade. This study was conducted to examine the impact of electronic banking on the financial performance of Nigerian deposit money banks. The data for the study was obtained from the Central Bank of Nigeria’s Statistical Bulletin and the National Bureau of Statistics’ Statistical Bulletin for various years, as well as from published financial statements of the banks under study. An ex-post facto research design was used and a normality test was carried out to establish the goodness of the data; descriptive statistics and a multicollinearity test were conducted in which the independent variables were found good. Regression was adopted to test two hypotheses. It was found that ATM has a positive and significant association with Earning EPS and ROA; POS and NEFT significantly affect ROA only, while WEB has an insignificant impact on both EPS and ROA. It is concluded that electronic banking significantly affects financial performance of deposit money banks in Nigeria. Thus, the study recommended that deposit money banks in Nigeria should educate their customers more in the use of NEFT, WEB, and POS, and that the amount of ATM withdrawals should be increased to improve bank performance.
Impact of Covid-19 on SME portfolios in Morocco: Evaluation of banking risk costs and the effectiveness of state support measures
Authors: Habachi Mohamed , El Haddad Salim
Published: September 2021

This study proposed a method for constructing rating tools using logistic regression and linear discriminant analysis to determine the risk profile of SME portfolios. The objective, firstly, is to evaluate the impact of the crisis due to the Covid-19 by readjusting the profile of each company by using the expert opinion and, secondly, to evaluate the efficiency of the measures taken by the Moroccan state to support the companies during the period of the pandemic. The analysis in this paper showed that the performance of the logistic regression and linear discriminant analysis models is almost equivalent based on the ROC curve. However, it was revealed that the logistic regression model minimizes the risk cost represented in this study by the expected loss. For the support measures adopted by the Moroccan government, the study showed that the failure rate (critical situation) of the firms benefiting from the support is largely lower than that of the non-beneficiaries.
Evaluation of R&D activities in the maritime industry: Managing sustainability transitions through business model
Authors: Koilo Viktoriia
Published: September 2021

The maritime industry is always at the forefront of knowledge and new technology. In recent years, the companies have used large resources in research and development (R&D) towards environmentally friendly technology. At the same time, there exist many issues around this: are those companies enough good at the utilizing of R&D fonds, i.e., do they put new technology together with solutions that are best adapted to the customer requirements (export-oriented), on the one hand, and are they efficient and sustainable, on another hand? Hence, the current paper aims to study how the R&D costs contribute to value creation and sustainable transition in the maritime industry. To achieve this goal, R&D activities in the maritime industry were analyzed using correlation and linear regression analyses between 2010 and 2019. The results show that those indicators that have the greatest positive impact on value-added are R&D expenditures in the business enterprise sector and turnover from product innovations. Also, it was revealed that there is a negative impact of trade indicators on value creation. In addition, the study proves that R&D activities are contributing to the sustainable transition of the maritime industry. Overall, it was concluded that without sufficient public support, strategy, and new business models, export-oriented industries benefit less from innovation. Acknowledgment The study is supported by a grant from the Research Based Innovation “SFI Marine Operation in Virtual Environment (SFI-MOVE)” (Project no: 237929) in Norway.
Investigation of random runway effect on landing of an aircraft with active landing gears using nonlinear mathematical model
Authors: Sivakumar S. , Selvakumaran T. , Sanjay B.
Published: September 2021

Random runway roughness effect on the dynamic response of an aircraft with landing gears has been investigated using nine degree of freedom nonlinear mathematical model. The developed mathematical model incorporates nonlinear characteristics of air spring stiffness, landing gear damping, tire stiffness and damping of the oleo pneumatic main landing gears and nose gear. Equation of motion for aircraft and each landing gear have been written considering heave, pitch, roll of aircraft and three vertical motions of landing gears respectively for landing response analysis. The equations for longitudinal motion of each landing gear are also written from the mathematical model will be helpful for longitudinal dynamics. The aircraft touchdown and roll on with variable decent velocities on Grade E random runway represented by nonstationary random process. The excitation of different grades of random runway can be considered as stationary random process when the aircraft landing at constant sink velocity. This work mainly focused on finding the dynamic responses of the aircraft such as heave, pitch, roll acceleration, vertical forces and all the three landing gears vertical vibration levels while landing on random runways. The active landing gear system performance is compared with passive landing gear system by numerical simulation in MATLAB/SIMULINK. The investigation using nonlinear model predicted that the effect of active control landing gear provides significant reduction in vibration levels and vertical reactions during landing at various vertical velocities on random runways. To validate the above mathematical model a multi-body dynamics (MBD) model has been simulated in ABAQUS/CAE and the dynamic responses of landing gear forces are compared with those obtained from the nonlinear mathematical model. The nonlinear model responses are also compared with the results of other authors. This study is more useful to adopt active control landing gear in the aircraft to reduce the landing loads transmit on aircraft structure and landing gears due to landing impact. The reduction of vibration levels and vertical forces by the active system increase the fatigue life of landing gears and structural life of airframe.
Accuracy assessment and error cause analysis of GPM (V06) in Xiangjiang river catchment
Authors: Tian Bingru , Chen Hua , Wang Jialing , Xu Chong-Yu
Published: September 2021

Application potential and development prospect of satellite precipitation products such as Tropical Rainfall Measuring Mission (TRMM) and Global Precipitation Mission (GPM) have promising implications. This study discusses causes of spatiotemporal differences on GPM data through the following steps: Initially, calculate bias between satellite-based data and rain gauge data of Xiangjiang river catchment to assess the accuracy of GPM (06E, 06 L, and 06F) products. Second, total errors of satellite precipitation data are divided into hit bias (HBIAS: precipitation detected by both GPM and rain gauge station), missed precipitation (MBIAS: precipitation detected only by rain gauge station), and false precipitation (FBIAS: precipitation detected only by GPM). Third, evaluate the impact of precipitation intensity and total precipitation on accuracy of GPM data and their influence on three error components. Several conclusions are drawn from the results above. (1) Satellite-based precipitation measurements perform better on a larger temporal-spatial scale. (2) The accuracy of TRMM and GPM data displays significant variances on space and time. Season, precipitation intensity, and total precipitation are main factors influencing the accuracy of TRMM and GPM data. (3) The detection capability of satellite products change with seasonal variation and different precipitation intensity level.
Evaluation of the biogas potential of a lignocellulosic residue
Authors: Guendouz Nardjes , Rezzaz-Yazid Hynda , Laib Salima , Sadaoui Zahra
Published: September 2021

Anaerobic digestion (AD) or methanization is a biological process that allows the treatment of organic wastes and the production of renewable energy as biogas. This research describes assessment and optimization of dates pedicels rich in organic components under the conditions of mesophiles in co-digestion in association with the cattle manure and sludge of the wastewater treatment plant (WWTP). To realize this objectives, we investigated the impact of substrate load (date pedicel) on the co-digestion anaerobic of date pedicels and the sludge in wastewater treatment plants. The different parameters of the digester stability such as the pH, VFA, CAT, ammoniacal nitrogen, and the volume of biogas produced were followed. The results show that by increasing the mass of the pedicels and therefore the percentage of the substrate in the reactor, from 0.5 to 1% (W/V), the volume of produced biogas increases by five times. However, an increase in the percentage of the substrate introduced into the digester from 1 to 2% resulted in a slight decrease in the volume of biogas produced. The use of fresh cattle manure as inoculum shown a significant improvement (40%) in the production of biogas, which can be attributed to the nature of the inoculum. Indeed, cattle manure fresh is more adapted for the fermentation of lignocellulosic materials unlike sludge of wastewater treatment plants which may contain toxic substances that limit their use in AD.
Supervivencia de pacientes con cáncer de próstata en un hospital de Bogotá, Colombia 2008-2014
Authors: Campos Guzmán Nelson Rolando
Published: September 2021

El cáncer de próstata es actualmente una de las principales patologías que afectan a los hombres. El objetivo del presente artículo fue estimar la supervivencia de los pacientes con cáncer de próstata de riesgo intermedio y alto pertenecientes al régimen especial de salud (militares). Se realizó un estudio de cohorte que estima la función de supervivencia con el método de Kaplan-Meier y el Hazard ratio (HR) en función de variables explicativas mediante un modelo de regresión de Cox. Los pacientes incluidos fueron diagnosticados por urología y/o confirmados con apoyos diagnósticos. No se incluyeron pacientes tratados para cáncer de próstata en otra institución o por tumores primarios diferentes a próstata y quienes consultaron para tomar una segunda opinión médica. Los pacientes de riesgo intermedio sobreviven en un 90% tanto a cinco como a siete años, y los de riesgo alto sobrevivieron en 35% y 30% a cinco y siete años, respectivamente, con una mediana de 28 meses. Este estudio permitió concluir que la supervivencia de los pacientes clasificados como riesgo intermedio es similar a la nacional e internacional; sin embargo, en los pacientes de alto riesgo la supervivencia es inferior respecto a otros países.
Vacunación contra COVID y embarazo
Authors: Carla Lorena Macchia de Sánchez , Villalba Vizcaíno Vivian Tatiana
Published: September 2021

Las vacunas constituyen un hito de la medicina. Con ellas se ha podido reducir la carga de las enfermedades infecciosas, logrando incluso la erradicación de algunas de ellas. Desde finales del año 2019 surgió un nuevo coronavirus, denominado SARS-CoV-2, el cual ha generado millones de muertes en el mundo y múltiples afectaciones económicas. Por esta razón es imperiosa la producción e implementación de una vacuna eficaz como una herramienta de prevención primaria. En esta carrera se han desarrollado varios modelos de vacunas que superaron las primeras fases de ensayos clínicos, dentro de los cuales no han sido incluidas pacientes embarazadas. Pese a la carencia de evidencia en referencia a esta población, la Organización Mundial de la Salud (OMS) y varias asociaciones de ginecología recomiendan actualmente considerar la vacunación en grupos de alto riesgo, como sería el caso de las trabajadoras de la salud. El presente artículo pretende mostrar los aspectos relevantes de la vacunación en embarazadas y las recomendaciones actuales a la luz de los conceptos relacionados con la inmunidad en embarazo.
Afrontamiento y tolerancia al estrés académico en situación de confinamiento según Calixta Roy
Authors: Acosta-Salazar Diana , Lapeira-Panneflex Patricia , Osorio-Duran Edna
Published: September 2021

Estudio cualitativo, fenomenológico, cuyo objetivo fue describir la adaptación al estrés académico con base en el Modelo de la Adaptación de Roy de los estudiantes del área básica con asignaturas en repitencia del Programa de Enfermería de una universidad pública. La muestra fueron 12 estudiantes, como criterio de inclusión estar matriculados cursando una asignatura del área básica por segunda vez y participación voluntaria. Técnica de recolección de la información fue entrevista semiestructurada. Los resultados evidenciaron el uso de los cuatro modos de adaptación definidos por Roy, en el modo de adaptación fisiológico presentaron trastornos de sueño y preocupación; en el modo autoconcepto establecen mecanismos de ayuda frente a su dificultad; en el modo función de rol realizan función de estudiante, hijo; en el de interdependencia por iniciativa los estudiantes afianzaron sus creencias para obtener fortalecimiento. Se concluye que los estudiantes en repitencia de una asignatura del área básica afrontaron el estrés académico adaptándose según el Modelo descrito por Calixta Roy, emplean los cuatro modos de adaptación, y en cuanto a los factores descrito por Roy los más utilizados por los estudiantes fueron el factor 4: Procesamiento sistemático, y el factor 5: Conociendo y relacionando.
Laserterapia diodo para estomatitis aftosa recurrente: reporte de un caso
Authors: Pulido-Rozo Myriam Amparo , Serpa-Romero Xiomara Zilena , Wilches-Visbal Jorge Homero
Published: September 2021

La estomatitis aftosa recurrente es una enfermedad oral caracterizada por la aparición de úlceras dolorosas en la mucosa labial o yugal. Su etiología es desconocida; suele afectar a personas menores de 30 años; pudiendo repetir durante meses o años. Antinflamatorios, glucocorticoides, antibióticos, entre otros, son tradicionalmente indicados para el manejo de las lesiones. Debido a los efectos colaterales de estos tratamientos, se ha sugerido la terapia láser. El objetivo del reporte fue establecer si el láser diodo de alta potencia desenfocado es efectivo contra la estomatitis aftosa de una paciente de 30 años, que padecía de úlceras bucales desde los 10 años, sin éxito  con los tratamientos tradicionales. Las lesiones se irradiaron con 1W de láser diodo, modo continuo con fibra de 400 µm seguido de onda plana y pieza disfocal angulada en lengua, labio interno y carrillos. Asimismo, se aplicó laserpuntura en zona extraoral, para un total de 10 sesiones. Se observó reducción completa del dolor al tercer día de irradiación. Después de 1 año de seguimiento no se evidenció recurrencia. Se concluye que el láser diodo mostró mejores resultados que los anteriores tratamientos al aliviar rápidamente el dolor, evitar la recidiva y mejorar la autoestima de la paciente.
Significado del puerperio en pandemia por COVID-19: nueva dimensión del cuidado
Authors: Lapeira-Panneflex Patricia , Osorio-Duran Edna , Castañeda-Mercado Rosemary
Published: September 2021

La emergencia sanitaria por la COVID-19 ha cambiado la dinámica del cuidado. El puerperio es una etapa de muchos cambios y supone vulnerabilidad en este grupo de mujeres, que por causas de las medidas de aislamiento no poseen apoyo social. El propósito de este estudio fue describir el significado del cuidado en el puerperio para la mujer en situación de pandemia. Se empleó la etnoenfermería (Leininger) con la entrevista no estructurada como método de recolección de los datos. Participaron en el estudio 8 puérperas como informantes claves, 2 madres y 2 suegras como informantes generales.  Para el análisis de la información se utilizó el método de Spradley”, el cual incluye los dominios, taxonomías, análisis componencial y temas. Los dominios resultantes: cuidarse la mujer durante el puerperio hoy es la manera de asegurar su salud en el futuro, cuidar a su hijo es la manera de evitar que se enferme. Se concluye que las mujeres puérperas adquieren con el contacto en su grupo social diferentes conceptos del cuidado, que por motivos de las medidas de aislamiento buscan fuentes de información como el internet, incorporándolas a su cotidianidad propagando creencias, costumbres y que se mantienen con el transcurso del tiempo
Impact of COVID-19 Infection on Maternal and Neonatal Outcomes: A
Review of 11078 Pregnancies Reported in the Literature
Authors: Azarkish Fatemeh , Janghorban Roksana
Published: September 2021

Background:

Pregnant women are a vulnerable group in viral outbreaks, especially in
the COVID-19 pandemic.

Objective:

The aim of this review was to identify maternal and neonatal outcomes in available articles
on pregnancies affected by COVID-19.

Methods:

The articles that had assessed outcomes of pregnancy and perinatal of women with
COVID-19 between Oct 2019 and Aug 2020 without language limitation were considered. We
searched databases, selected relevant studies and extracted data regarding maternal and neonatal
outcomes from each article.

Results:

Data of 11078 pregnant women with COVID-19 of 23 countries were assessed from 77 articles
between December 8, 2019 and Aug 18, 2020. Most pregnant women reported in their third
trimester, out of which 6229 (56.22%) cases were symptomatic at the time of admission. Common
onset symptoms, abnormal laboratory findings, and chest computed tomography pattern were
cough (40.88%%), lymphocytopenia (43.38%), and multiple ground-glass opacities (4.42%), respectively.
51.37% of all deliveries were done through cesarean section. 158 maternal mortality
and 4.2% ICU admission were reported. Vertical transmission was not reported, but its possibility
was suggested in thirty-two neonates. Ten neonatal deaths, thirteen stillbirths, and nineteen abortions
were reported. 60% of newborns were not breastfed.

Conclusion:

This review showed fewer adverse maternal and neonatal outcomes in pregnant women
with COVID-19 in comparison with previous coronavirus outbreak infection in pregnancy.
Limited data are available regarding the possibility of virus transmission in utero, during vaginal
childbirth and breastfeeding. The effect of COVID-19 on the first and second trimesters and ongoing
pregnancy outcomes in infected mothers is still questionable.
Total Stromal Fraction (TSF) - Fortified Adipose Tissue-Derived Stem
Cells Source: An Emerging Regenerative Realm Against COVID-19 Induced
Pulmonary Compromise
Authors: Jha Niraj Kumar , Kamal Mohammad Amjad , Kesari Kavindra Kumar , Jha Saurabh Kumar , Jeyaraman Madhan , Muthu Sathish , Jain Rashmi , Satish Ajay Shringeri , Garg Neha , Mishra Prabhu Chandra , Swati Kumari , Parkash Anand , Ojha Shreesh , Roychoudhury Shubhadeep , Kumar Dhruv , Ruokolainen Janne
Published: September 2021

:

The inception of the COVID-19 pandemic has jeopardized humanity with markedly dampening
of worldwide resources. The viral infection may present with varying signs and symptoms,
imitating pneumonia and seasonal flu. With a gradual course, this may progress and result in the
deadliest state of acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). Moreover,
following recovery from the severe brunt of COVID-19 infection, interstitial portions of alveoli
have been found to undergo residual scarring and further to have compromised air exchange.
Such alterations in the lung microenvironment and associated systemic manifestations have been
recognized to occur due to the extensive release of cytokines. The mortality rate increases with advancing
age and in individuals with underlying co-morbidity. Presently, there is no availability of
specific antiviral therapy or any other definitive modality to counter this progressive worsening.
However, we believe principles and advancing cell-based therapy may prove fruitful in subjugating
such reported worsening in these patients. This article reviews eminent knowledge and relevant advancements
about the amelioration of lung damage due to COVID-19 infection using adipose tissue-
derived - total stromal fraction (TSF).
sorry I want to withdraw the manuscript for some personal reason. (Preprint)
Authors: X F
Published: September 2021

UNSTRUCTURED

sorry I want to withdraw the manuscript for some personal reason.
The Language Features and Translation of Business Contracts
Authors: Chunying Li
Published: September 2021

Since the reform and opening up policy was adopted, Chinese economy has been keeping on developing with high speed, so as to its international trade. Therefore, English business contracts are widely used in the foreign economic and trade activities. However, we also find that there are still many foreign-related economic disputes which mainly caused by the ambiguity of translation happening in these trades. Due to the unclear rules of the parties’ obligations and rights, the improper translation of the contract, the meaning vague and the loose broad, the parties are tracked in this situation where any part of them could intentionally or unintentionally exploited a contractual loophole to avoid responsibility and obligation, which would lead to a dispute. The distortion of translation can lead to the fuzziness and uncertainty of contract which can be easily exploited by commercial fraud to evade responsibility; this situation is happened in reality and practice which has negative impact on foreign relations and trade. In order to make the business activities carried out more effectively, this article will discuss it mainly from the perspective of lexical characteristics and translation principal of business contract in order to make the translation be more accurate to benefit international business trade.
IoT based Employee Wellness Program
Authors: Mohammed Ismail
Published: September 2021

Abstract: Owing to globalization, employees spend 60-70% of their time in their offices hence they offer an important venue for influencing dietary behaviour of employees [1, 3]. With the increased technology and usage of sensors, the application of Internet based smart health monitoring has emerged at a greater pace. Internet of Things (IoT) is the new revolution which is the growing research area especially in the health care domain [7]. The current work presents a methodology that links the employee health to risk factors such as diet and physical activity and provides an exclusive diet plan to each employee through IoT enabled devices and network. A portable IoT enabled weighing scale setup was constructed using a Bench scale RSL 601AC Load Cell, Load Cell Amplifier HX711, Node MCU, RF ID and card reader to record the employee data & upload it to cloud. A .NET application was developed to download the data from the cloud and determine the BMI of an employee and the corresponding calories to be consumed and expended in a day. Taking into account the calories to be consumed and the diet preferences, the application then constructs a diet plan and sends it across to the employees and generates weekly statistical data of BMI to guide and monitor the overall fitness of the employees. Keywords: Dietary behaviour, BMI, Internet of Things (IoT), Diet plan, Fitness
Ideologies and Imaginaries in Blockchain Communities: The Case of Ethereum
Authors: Brody Ann , Couture Stéphane
Published: September 2021

Background: Academic literature on blockchains has focused on Bitcoin, which is traditionally associated with right-wing libertarianism. This article looks at Ethereum, an alternative that emerged in Canada and is now the second most used blockchain technology after Bitcoin.

Analysis: Using participatory observation supplemented with publicly available material, this article examines the ideologies and imaginaries surrounding Ethereum and how they are articulated with its technical design.

Conclusion and implications: Ethereum’s design ostensibly widens the ideological spectrum of cryptocurrency while “masking” certain currency ideologies still prominent within it. This complicates the distinction seen in the literature between blockchain as currency and blockchain as media and points to the increasing need to study non-currency-based blockchain technologies.
Experiential Learning in the Canadian Communications Landscape
Authors: Smeltzer Sandra , Pieber Darryl A. , Brooks Mason
Published: September 2021

Background: This article critically analyzes the results of an online survey about curricular experiential learning (EL) completed by 36 Canadian communication studies programs.

Analysis: Attention is focused on internships, co-ops, and community engaged learning. Six key areas illuminate the current EL terrain: types and scope of EL endeavours, pedagogical requirements and hourly commitments, student remuneration, logistical and scholarly oversight, EL partners and student activities, and stakeholder demand.

Conclusions and implications: We highlight five issues emerging from the data that deserve greater attention and argue that scholars must proactively engage in conversations about the role that EL plays in the field.
Penolakan Saksi Testimonium De Auditu sebagai Alat Bukti dalam Putusan Mahkamah Syariah Aceh Nomor 7/JN/2021/MS Aceh
Authors: Bustamam Amrullah
Published: September 2021

AbstrakVonis bebas oleh hakim Mahkamah Syar'iyah Aceh  terhadap terdakwa  kasus pemerkosa  di Aceh Besar, tertuang dalam putusan perkara banding Nomor 7/JN/2021/MS Aceh yang membatalkan Putusan Majelis Hakim Mahkamah Syar’iyah Jantho Nomor 22/JN/2020/MS-Jth, dalam putusan ini majelis hakim menolak saksi tertimoni Permasalahannya adalah bagaimana kedudukan saksi testimoni dalam KUHAP serta dalam putusan Mahkamah Konstitusi dan bagaimana pertimbangan majelis hakim MS Aceh terhadap saksi testimoni yang di ajukan JPU?. Studi ini adalah studi normatif. Hasil studi ini menujukkan bahwa majelis hakim menganggap keterangan dari saksi yang tidak melihat sendiri dan mengalami sendiri peristiwa pidana maka harus ditolak, kemudian keberadaan saksi testimoni dalam KUHAP tidak mempunyai kekuatan seperti saksi pada umumnya namun dalam Putusan Mahkamah Konstitusi Nomor 65/puu-viii/2010 tentang pengujian KUHAP telah mengakui kekuatan alat bukti saksi testimoni sama dengan keterangan saksi lainnya. Kesimpulannya seharusnya majelis hakim MS Aceh harus menerima keterangan saksi testimoni.Kata Kunci : Saksi, Testimoni, Putusan MK 2010
DUALISME KEWENANGAN DALAM PENYELESAIAN PERKARA TINDAK PIDANA PENCABULAN TERHADAP ANAK DI ACEH (Perkara Nomor 231/Pid.Sus/2018/ PN Bna dan 005/JN/2017/Ms-Lgs)
Authors: Rispalman Rispalman , Abbas Syahrizal , Ariani Desi
Published: September 2021

AbstrakTerdapat dualisme kewenangan dalam penyelesaian perkara tindak pidana pencabulan terhadap anak di Aceh. Prakteknya dualisme kewenangan terjadi dalam penyelesaian perkara tinda pidana pencabulan terhadap anak di Aceh dimana pada perkara Nomor 231/Pid.Sus/2018/PN Bna diselesaikan di Pengadilan Negeri Banda Aceh dan perkara Nomor 005/JN/2017/Ms-Lgs di selesaikan di Mahkamah Syar’iyah Langsa. Rumusan masalah dalam penelitian skripsi ini adalah mengapa terjadi dualisme kewenangan dalam penyelesaian perkara tindak pidana pencabulan terhadap anak di Aceh dan apa dasar yuridis Pengadilan negeri Banda Aceh dan Mahkamah Syar’iyah Langsa dalam mengadili perkara pencabulan terhadap anak. Penelitian ini menggunakan penelitian yuridis normatif. Dualisme terjadi dikarenakan Qanun Jinayat dan Undang-undang Perlindungan Anak (UUPA) mengatur pencabulan terhadap anak. Adapun landasan yuridis Pengadilan Negeri dalam penyelesaian perkara tindak pidana pencabulan terhadap anak pada perkara Nomor 231/Pid.Sus/2018/PN Bna menggunakan Undang-undang Nomor 35 Tahun 2014 tentang Perlindungan Anak (UUPA), dan landasan yuridis Mahkamah Syar’iyah dalam penyelesaian perkara tindak pidana pencabulan terhadap anak pada perkara Nomor 005/JN/2017/Ms-Lgs menggunakan Pasal 47 Qanun Aceh Nomor 6 Tahun 2014 tentang Hukum Jinayat. Proses peradilan terhadap Qanun Aceh Nomor 6 Tahun 2014 tentang Hukum Jinayat dilaksanakan di Mahkamah Syar’iyah. Secara norma yang berwenang mengadili ialah Mahkamah Syar’iyah dengan menerapkan Qanun Jinayat.  Kata Kunci: Dualisme Kewenangan, Penyelesaian, dan Pencabulan Anak.
Minoritas di Wilayah Syariat: Kedudukan Non Muslim Dalam Qanun Hukum Jinayat Aceh
Authors: Melayu Hasnul Arifin , Abubakar Mohammad Zawawi , MohammadNasir Norruzeyati Che
Published: September 2021

AbstrakQanun yang berkaitan dengan syariat Islam hanya berlaku bagi umat Islam yang berada di Aceh. Konsepsi ini secara spesifik mengadopsi asas personalitas dan teritorialitas. Namun bila dikaji lebih mendalam, dapat dilihat bahwa pengadopsian kedua asas tersebut ternyata tidak secara total berlaku. Dampak yang muncul bahwa Qanun Hukum Jinayat(QHJ) tetap berlaku bagi umat Islam dan bukan Islam meskipun dengan beberapa persyaratan. Dari sinilah masalah mulai muncul. Tulisan ini atas dasar analisis isi pasal-pasal Qanun Hukum Jinayat menunjukkan bahwa eksistensi Qanun ini khususnya yang mengatur tentang kedudukan non muslim di Aceh. Data primer dalam tulisan ini adalah pasal-pasal dalam Qanun Hukum Jinayat dan ditambah dengan sumber-sumber tulisan lainnya. Ditemukan bahwa pengadopsian kedua asas dalam Qanun Hukum Jinayat seyogyanya tidak menghilangkan prinsip fundamental Islam yang menjunjung tinggi keadilan dan menghargai hak asasi manusia. Kajian mendalam dan komprehensif mutlak diperlukan untuk menghasilkan peraturan yang lebih adil.  Kata Kunci: Syari’at Islam, Qanun, Aceh, Non-Muslim
KOMPILASI HUKUM ISLAM DI INONESIA Penyusunan dan Kaitannya dengan Ushul Fiqh
Authors: Sulfanwandi Sulfanwandi
Published: September 2021

AbstrakDilihat dari hukum tata negara, landasan hukum KHI itu masih lemah karena menempatkan KHI dalam posisi hukum yang tidak tertulis ditambah lagi materi KHI terpisah dari lnpres tersebut. Disamping itu posisi KHI sebagai pedoman dalam berperkara menempatkan hakim dan masyarakat pencari keadilan untuk tidak terikat padanya. Oleh karena itu, secara teoritis KHI tetap saja tidak bisa memberi kepastian hukum yang merupakan tuntutan masyarakat Indonesia moderen. Dengan demikian sumbangsih hukum Islam dalam pembinaan hukum nasional menjadi semakin jauh dari harapan. Selanjutnya dari segi efektifitasnya di masyarakat perlu ditinjau lebih lanjut. Hal ini disebabkan oleh adanya pemahaman yang keliru dalam masyarakat yang menyatakan bahwa hukum Islam itu hanya terdapat dalam kitab-kitab fiqh. Padahal kitab-kitab fiqh merupakan satu bagian saja dari hukum Islam. Disanrpingnya terdapat fatwa-fatwa ulama, peraturan perundang-undangan negeri- negeri muslim, dan keputusan Pengadilan Agama. Oleh karena itu diperlukan sosialisasi KHI di masyarakat sekaligus diperlukan usaha-usaha untuk meluruskan kekeliruan pemahaman terhadap hukum Islam tersebut. Kata Kunci: Metode, Kompilasi Hukum Islam
KONSEP KEADILAN TERHADAP DELIK PEMBUNUHAN (Analisis Komparatif Hukum Islam dan KUHP)
Authors: Hadana Erha Saufan , Rizqi Beri
Published: September 2021

ABSTRAKKajian ini membahas mengenai delik pembunuhan yang merupakan perbuatan yang menjatuhkan hak asasi manusia oleh karenanya delik pembunuhan ini diatur dalam KUHP sebagai suatu tindak pidana terhadap nyawa manusia. Pengaturan tentang delik pembunuhan ini diatur dalam Al Qur’an dan dipertegas oleh hadits, keduanya mengatur tentang jenis delik pembunuhan, sanksi, serta bagaimana pelaksanaan hukuman. Meskipun masyarakat Indonesia mayoritas beragama Islam, hukum yang diterapkan adalah hukum peninggalan Belanda, yang pada kenyataannya berbeda sekali dengan hukum Islam. Sehubungan dengan hal diatas, metode yang digunakan dalam penulisan ini adalah studi pustaka (library research) terhadap Al Qur’an, Hadits, KUHP serta peraturan perundang-undangan yang lainnya. Kemudian secara komparatif penulis membandingkan beberapa konsep dalam hukum positif dan hukum Islam yang ada kaitannya dengan permasalahan untuk mendapatkan konsep hukum yang lebih mendekati kebenaran. Dari hasil penelitian disimpulkan Hukum pidana positif menjunjung nilai-nilai kemanusiaan yang universal, namun untuk memberikan rasa keadilan sangat ditentukan oleh putusan hakim, tanpa dimintai pertimbangan dari pihak keluarga korban. Hukum pidana Islam menjunjung nilai-nilai kemanusiaan yang universal dan memberikan rasa keadilan yang seimbang dengan menempatkan keluarga korban sebagai unsur penentu dalam menjatuhkan hukuman pidana mati terhadap pelaku pidana pembunuhan. Penjatuhan hukuman mati atau dibebaskan dari hukuman mati didasarkan pada itikad baik keluarga korban. Kata Kunci: Keadilan, Delik Pembunahan, Hukum Islam, KUHP
Determinantes de la lealtad en la relación entre la Liga Antioqueña de Tenis de Campo y sus clientes
Authors: Ávila-Rodríguez Oscar Eduardo , Correa-Henao Silvana Janeth , Henao-Colorado Laura Cristina , Monroy-Escudero Héctor Alonso , Brand-Ortiz Jorge Iván
Published: September 2021

Las organizaciones deportivas deben tomar decisiones acertadas en el ámbito del marketing, por lo que es necesario que dichas decisiones se basen en estudios que permitan identificar las características de las relaciones que mantienen con sus clientes, esto con el fin de que estas sean duraderas en el tiempo. En la literatura mundial se evidencian estudios que relacionan el entorno empresarial con el deportivo, pero pocos han estudiado este tipo de relación utilizando en su conjunto los constructos de satisfacción, valor percibido, confianza, compromiso y lealtad. Por lo tanto, este artículo pretende analizar los determinantes de la lealtad en la relación de la Liga Antioqueña de Tenis de Campo con sus clientes. La investigación se llevó a cabo a través de una metodología mixta que incluye dos fases: una fase exploratoria para comprender el problema de investigación y establecer las hipótesis, y otra descriptiva, de corte transversal simple, con análisis mediante un modelo de ecuaciones estructurales, bajo el enfoque de mínimos cuadrados parciales. El estudio arrojó una confirmación total de las hipótesis planteadas para el modelo, evidenciando los determinantes de la lealtad indicados por el marketing relacional en el contexto deportivo, específicamente en el de la Liga Antioqueña de Tenis de Campo y sus usuarios, encontrando que los determinantes directos de la lealtad, y que presentan un efecto positivo, son la satisfacción, la confianza y el compromiso.
Sociale senfølger hos børnekræftoverlevere
Authors: Carlsen Line Thoft
Published: September 2021

Livet forandres uden varsel for børn og familier, der rammes af børnekræft. Den trygge og kendte hverdag ændres, og børnekræftpatienter mister muligheden, periodisk eller permanent, for at leve et »normalt« børne- og ungdomsliv. Børnekræftoverlevere fortæller, at deres overlevelse af kræften betegnes med positive ord såsom en succes og en sejr, og at »man« har vundet over kræften. At overleve kræft og vinde livet er dog sjældent uden fysiske, mentale og sociale konsekvenser. Der er en underbelyst skyggeside: et liv med senfølger, der fylder meget for overleverne og har store konsekvenser for deres mulighed for at indgå i og bidrage til samfundet. Artiklen er et empirisk vidensbidrag, der præsenterer delresultater fra ph.d.-projektet »Sociale konsekvenser af børnekræft« med udgangspunkt i kvalitative interviews og observationsstudier af og med 23 børnekræftoverlevere (18-39 år). Artiklen formidler viden om nogle af de sociale senfølger af børnekræft, der kan optræde i ungdoms- og voksenlivet. Yderligere belyser artiklen, hvorfor der ikke er mere fokus på senfølger, og hvilke forklaringer børnekræftoverlevere selv har på dette. I tillæg benyttes Erwing Goffmans og Aaron Antonovskys teorier samt anden relevant forskningslitteratur om børnekræftoverlevere til at forstå og underbygge de udfordringer, børnekræftoverlevere beskriver.