bluuebunny/crossref_metadata_2025 huggingface dataset:
Adenovirus Infections in African Humans and Wild Non-Human Primates: Great Diversity and Cross-Species Transmission
Authors: Medkour Hacène , Amona Inestin , Akiana Jean , Davoust Bernard , Bitam Idir , Levasseur Anthony , Tall Mamadou Lamine , Diatta Georges , Sokhna Cheikh , Hernandez-Aguilar Raquel Adriana , Barciela Amanda , Gorsane Slim , La Scola Bernard , Raoult Didier , Fenollar Florence , Mediannikov Oleg
Published: June 2020

Non-human primates (NHPs) are known hosts for adenoviruses (AdVs), so there is the possibility of the zoonotic or cross-species transmission of AdVs. As with humans, AdV infections in animals can cause diseases that range from asymptomatic to fatal. The aim of this study was to investigate the occurrence and diversity of AdVs in: (i) fecal samples of apes and monkeys from different African countries (Republic of Congo, Senegal, Djibouti and Algeria), (ii) stool of humans living near gorillas in the Republic of Congo, in order to explore the potential zoonotic risks. Samples were screened by real-time and standard PCRs, followed by the sequencing of the partial DNA polymerase gene in order to identify the AdV species. The prevalence was 3.3 folds higher in NHPs than in humans. More than 1/3 (35.8%) of the NHPs and 1/10 (10.5%) of the humans excreted AdVs in their feces. The positive rate was high in great apes (46%), with a maximum of 54.2% in chimpanzees (Pan troglodytes) and 35.9% in gorillas (Gorilla gorilla), followed by monkeys (25.6%), with 27.5% in Barbary macaques (Macaca sylvanus) and 23.1% in baboons (seven Papio papio and six Papio hamadryas). No green monkeys (Chlorocebus sabaeus) were found to be positive for AdVs. The AdVs detected in NHPs were members of Human mastadenovirus E (HAdV-E), HAdV-C or HAdV-B, and those in the humans belonged to HAdV-C or HAdV-D. HAdV-C members were detected in both gorillas and humans, with evidence of zoonotic transmission since phylogenetic analysis revealed that gorilla AdVs belonging to HAdV-C were genetically identical to strains detected in humans who had been living around gorillas, and, inversely, a HAdV-C member HAdV type was detected in gorillas. This confirms the gorilla-to-human transmission of adenovirus. which has been reported previously. In addition, HAdV-E members, the most often detected here, are widely distributed among NHP species regardless of their origin, i.e., HAdV-E members seem to lack host specificity. Virus isolation was successful from a human sample and the strain of the Mbo024 genome, of 35 kb, that was identified as belonging to HAdV-D, exhibited close identity to HAdV-D members for all genes. This study provides information on the AdVs that infect African NHPs and the human populations living nearby, with an evident zoonotic transmission. It is likely that AdVs crossed the species barrier between different NHP species (especially HAdV-E members), between NHPs and humans (especially HAdV-C), but also between humans, NHPs and other animal species.
Preliminary Data Related to the Effect of Climacostol Produced by the Freshwater Ciliate Climacostomum virens on Human Adenovirus
Authors: Verani Marco , Di Giuseppe Graziano , Federigi Ileana , Buonanno Federico , Ortenzi Claudio , Carducci Annalaura
Published: June 2020

The new epidemiological scenario has so far focused on the environmental circulation of human viral pathogens. Owing to the side effects of chemical disinfectants, there is an increasing need for knowledge on the use of virucidal compounds, especially those of a natural origin. Climacostol is a molecule produced by a freshwater ciliate and it exhibits activity against bacterial and fungal pathogens. We thus also speculated that there might be an effect on viral viability, which has never been tested. To evaluate such activity, we chose human adenovirus (HAdV), which is representative of waterborne viruses. We conducted experiments using HAdV serotype 5, whose titer was determined by infecting HeLa cell cultures. HAdV5 was shown to be sensitive to climacostol at a concentration of 0.0002 mg/mL, with an approximate 3 Log10 reduction when the initial titer of HAdV5 was approximately 104 and 103 TCID50/mL. These preliminary results could be an important starting point for further research aimed at improving the characterization of climacostol activity under different experimental conditions and against various viruses, including enveloped ones (i.e., the coronavirus). The production of climacostol by a protist living in fresh water also suggests a possible application in the activated sludge of wastewater treatment plants.
PD-1 Immune Checkpoint Blockade Promotes Therapeutic Cancer Vaccine to Eradicate Lung Cancer
Authors: Kadam Pournima , Sharma Sherven
Published: June 2020

(1) Background: Targeting inhibitory immune checkpoint molecules has highlighted the need to find approaches enabling the activation of immune responses against cancer. Therapeutic vaccination, which induces specific immune responses against tumor antigens (Ags), is an attractive option. (2) Methods: Utilizing a K-RasG12Dp53null murine lung cancer model we determined tumor burden, tumor-infiltrating T cell (TIL) cytolysis, immunohistochemistry, flow cytometry, and CD4 and CD8 depletion to evaluate the efficacy of PD-1 blockade combined with CCL21-DC tumor lysate vaccine. (3) Results: Anti-PD-1 plus CCL21-DC tumor lysate vaccine administered to mice bearing established tumors (150 mm3) increased expression of perforin and granzyme B in the tumor microenvironment (TME), increased tumor-infiltrating T cell (TIL) activity, and caused 80% tumor eradication. Mice with treatment-induced tumor eradication developed immunological memory, enabling tumor rejection upon challenge and cancer-recurrence-free survival. The depletion of CD4 or CD8 abrogated the antitumor activity of combined therapy. PD-1 blockade or CCL21-DC tumor lysate vaccine monotherapy reduced tumor burden without tumor eradication. (4) Conclusion: Immune checkpoint blockade promotes the activity of the therapeutic cancer vaccine. PD-1 blockade plus CCL21-DC tumor lysate vaccine therapy could benefit lung cancer patients.
Expression of the Reverse Transcriptase Domain of Telomerase Reverse Transcriptase Induces Lytic Cellular Response in DNA-Immunized Mice and Limits Tumorigenic and Metastatic Potential of Murine Adenocarcinoma 4T1 Cells
Authors: Jansons Juris , Bayurova Ekaterina , Skrastina Dace , Kurlanda Alisa , Fridrihsone Ilze , Kostyushev Dmitry , Kostyusheva Anastasia , Artyuhov Alexander , Dashinimaev Erdem , Avdoshina Darya , Kondrashova Alla , Valuev-Elliston Vladimir , Latyshev Oleg , Eliseeva Olesja , Petkov Stefan , Abakumov Maxim , Hippe Laura , Kholodnyuk Irina , Starodubova Elizaveta , Gorodnicheva Tatiana , Ivanov Alexander , Gordeychuk Ilya , Isaguliants Maria
Published: June 2020

Telomerase reverse transcriptase (TERT) is a classic tumor-associated antigen overexpressed in majority of tumors. Several TERT-based cancer vaccines are currently in clinical trials, but immune correlates of their antitumor activity remain largely unknown. Here, we characterized fine specificity and lytic potential of immune response against rat TERT in mice. BALB/c mice were primed with plasmids encoding expression-optimized hemagglutinin-tagged or nontagged TERT or empty vector and boosted with same DNA mixed with plasmid encoding firefly luciferase (Luc DNA). Injections were followed by electroporation. Photon emission from booster sites was assessed by in vivo bioluminescent imaging. Two weeks post boost, mice were sacrificed and assessed for IFN-γ, interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α) production by T-cells upon their stimulation with TERT peptides and for anti-TERT antibodies. All TERT DNA-immunized mice developed cellular and antibody response against epitopes at the N-terminus and reverse transcriptase domain (rtTERT) of TERT. Photon emission from mice boosted with TERT/TERT-HA+Luc DNA was 100 times lower than from vector+Luc DNA-boosted controls. Bioluminescence loss correlated with percent of IFN-γ/IL-2/TNF-α producing CD8+ and CD4+ T-cells specific to rtTERT, indicating immune clearance of TERT/Luc-coexpressing cells. We made murine adenocarcinoma 4T1luc2 cells to express rtTERT by lentiviral transduction. Expression of rtTERT significantly reduced the capacity of 4T1luc2 to form tumors and metastasize in mice, while not affecting in vitro growth. Mice which rejected the tumors developed T-cell response against rtTERT and low/no response to the autoepitope of TERT. This advances rtTERT as key component of TERT-based therapeutic vaccines against cancer.
Vaccination with Recombinant Subolesin Antigens Provides Cross-Tick Species Protection in Bos indicus and Crossbred Cattle in Uganda
Authors: Kasaija Paul D. , Contreras Marinela , Kabi Fredrick , Mugerwa Swidiq , de la Fuente José de la
Published: June 2020

Cattle tick infestations and transmitted pathogens affect animal health, production and welfare with an impact on cattle industry in tropical and subtropical countries. Anti-tick vaccines constitute an effective and sustainable alternative to the traditional methods for the control of tick infestations. Subolesin (SUB)-based vaccines have shown efficacy for the control of multiple tick species, but several factors affect the development of new and more effective vaccines for the control of tick infestations. To address this challenge, herein we used a regional and host/tick species driven approach for vaccine design and implementation. The objective of the study was to develop SUB-based vaccines for the control of the most important tick species (Rhipicephalus appendiculatus, R. decoloratus and Amblyomma variegatum) affecting production of common cattle breeds (Bos indicus and B. indicus x B. taurus crossbred) in Uganda. In this way, we addressed the development of anti-tick vaccines as an intervention to prevent the economic losses caused by ticks and tick-borne diseases in the cattle industry in Uganda. The results showed the possibility of using SUB antigens for the control of multiple tick species in B. indicus and crossbred cattle and suggested the use of R. appendiculatus SUB to continue research on vaccine design and formulation for the control of cattle ticks in Uganda. Future directions would include quantum vaccinology approaches based on the characterization of the SUB protective epitopes, modeling of the vaccine E under Ugandan ecological and epidemiological conditions and optimization of vaccine formulation including the possibility of oral administration.
Assessment of the Main Geochemical Processes Affecting Surface Water and Groundwater in a Low-Lying Coastal Area: Implications for Water Management
Authors: Greggio Nicolas , Giambastiani Beatrice M. S. , Mollema Pauline , Laghi Mario , Capo Donato , Gabbianelli Giovanni , Antonellini Marco , Dinelli Enrico
Published: June 2020

Hydrogeochemical analyses were carried out to identify geochemical processes occurring in the low-lying coastal aquifer of Ravenna, North Adriatic Sea (Italy). The area is characterized by a complex coexistence of several environments: coastal dunes, paleodunes, pine forests, freshwater wetlands, rivers, brackish lagoons, gravel pit lakes, reclaimed lands, agricultural fields and industrial areas. Water quality is of primary importance for the sustainability of these, areas and a full understanding of geochemical processing is fundamental for their management. A total of 104 water samples was collected from groundwater wells and surface water bodies, and analyzed for the major and trace elements (TEs). Field measurements of chemical-physical parameters were carried out by a multiparameter device XS PCD650; major elements were analyzed following the Italian National Environmental Agency standards (APAT-IRSA 2003), while TEs were analyzed by ICP-AES/ICP-MS. The major findings include: organic matter degradation in salinized and anoxic conditions; TEs concentrations related to water–sediment interactions, i.e., adsorption, ion exchange, redox reactions, mineral dissolution and precipitation; anthropogenic contamination from pesticides and fertilizers use; pollution from industrial district; TEs enrichments and depletion due to groundwater salinization and water management practices; comparison of TEs concentrations with respect to national and international thresholds. The findings can provide water managers and local authorities with a comprehensive framework of the coastal water hydrochemistry, allowing a better understanding of the effects of current management practices and the design of mitigation measures to reduce water resource deterioration in the studied coastal area.
Hay Yield and Water Use Efficiency of Alfalfa under Different Irrigation and Fungicide Regimes in a Semiarid Climate
Authors: Djaman Koffi , Smeal Daniel , Koudahe Komlan , Allen Samuel
Published: June 2020

Alfalfa is one of the most nutritive and high-yielding forage legumes planted in rotation with cereal crops across the United States. Under semiarid and arid climates with limited water resources, sustainable management of the available resources is required. The objective of this study was to investigate the effect of different irrigation regimes and fungicide applications on alfalfa in the high desert region of the Colorado Plateau of the U.S. Field experiments were conducted during the 2012–2014 period. Alfalfa was planted in fall 2012, uniformly irrigated for crop establishment and subjected to seven different irrigation regimes after the first cut in spring 2013. Alfalfa was treated by fungicide application and was harvested at 10% blooming. The maximum amounts of applied water were 350, 300, 208, and 312 mm, respectively, during the first, second, third, and fourth regrowth cycles in 2013, and 373, 282, 198, and 246 mm in 2014 for the respective regrowth cycles in 2014; the seasonal applied irrigation amount varied from 711 to 1171 mm in 2013 and from 328 to 1100 mm in 2014. The results showed non-significant effect of fungicide application on the forage yield. Alfalfa forage yield was significantly affected by the irrigation regimes and showed a third order polynomial relationship with the applied irrigation amounts during each regrowth cycle and on seasonal scale. Forage yield decreased from the first cut to the fourth cut and the annual forage varied from 10.6 to 25.7 Mg/ha for the treated alfalfa and from 11.5 to 25.6 Mg/ha for the non-treated alfalfa. Forage yield at each cut accounted for 39.6, 24.2, 17.6, and 18.6% of the 2013 season forage yield and 31.4, 23.8, 21.6, and 23.2% of the 2014 season forage yield, for the first, second, third, and fourth cut, respectively. Alfalfa water use efficiency varied from 0.06 to 3.3 kg/m3. The relationships developed in this study could be used by forage growers, crop consultants, and project managers for decision making and planning to improve the productivity of water under the semiarid and arid climate of New Mexico and the surrounding regions.
Retrieval of Soil Moisture by Integrating Sentinel-1A and MODIS Data over Agricultural Fields
Authors: Han Yizhi , Bai Xiaojing , Shao Wei , Wang Jie
Published: June 2020

Soil moisture is an essential variable in the land surface ecosystem, which plays an important role in agricultural drought monitoring, crop status monitoring, and crop yield prediction. High-resolution radar data can be combined with optical remote-sensing data to provide a new approach to estimate high-resolution soil moisture over vegetated areas. In this paper, the Sentinel-1A data and the Moderate Resolution Imaging Spectroradiometer (MODIS) data are combined to retrieve soil moisture over agricultural fields. The advanced integral equation model (AIEM) is utilized to calculate the scattering contribution of the bare soil surface. The water cloud model (WCM) is applied to model the backscattering coefficient of vegetated areas, which use two vegetation parameters to parameterize the scattering and attenuation properties of vegetation. Four different vegetation parameters extracted from MODIS products are combined to predict the scattering contribution of vegetation, including the leaf area index (LAI), the fraction of photosynthetically active radiation (FPAR), normalized difference vegetation index (NDVI), and the enhanced vegetation index (EVI). The effective roughness parameters are chosen to parameterize the AIEM. The Sentinel-1A and MODIS data in 2017 are used to calibrate the coupled model, and the datasets in 2018 are used for soil moisture estimation. The calibration results indicate that the Sentinel-1A backscattering coefficient can be accurately predicted by the coupled model with the Pearson correlation coefficient (R) ranging from 0.58 to 0.81 and a root mean square error (RMSE) ranging from 0.996 to 1.401 dB. The modeled results show that the retrieved soil moisture can capture the seasonal dynamics of soil moisture with R ranging from 0.74 to 0.81. With the different vegetation parameter combinations used for parameterizing the scattering contribution of the canopy, the importance of suitable vegetation parameters for describing the scattering and attenuation properties of vegetation is confirmed. The LAI is recommended to characterize the scattering properties. There is no obvious clue for selecting vegetation descriptors to characterize the attenuation properties of vegetation. These promising results confirm the feasibility and validity of the coupled model for soil moisture retrieval from the Sentinel-1A and MODIS data.
Comparing Trends in Modeled and Observed Streamflows at Minimally Altered Basins in the United States
Authors: Hodgkins Glenn A. , Dudley Robert W. , Russell Amy M. , LaFontaine Jacob H.
Published: June 2020

We compared modeled and observed streamflow trends from 1984 to 2016 using five statistical transfer models and one deterministic, distributed-parameter, process-based model, for 26 flow metrics at 502 basins in the United States that are minimally influenced by development. We also looked at a measure of overall model fit and average bias. A higher percentage of basins, for all models, had relatively low trend differences between modeled and observed mean/median flows than for very high or low flows such as the annual 1-day high and 7-day low flows. Mean-flow metrics also had the largest percentage of basins with relatively good overall model fit and low bias. The five statistical transfer models performed better at more basins than the process-based model. The overall model fit for all models, for mean and/or high flows, was correlated with one or more measures of basin precipitation or aridity. Our study and previous studies generally observed good model performance for high flows up to 90th or 95th percentile flows. However, we found model performance was substantially worse for more extreme flows, including 99th percentile and annual 1-day high flows, indicating the importance of including more extreme high flows in analyses of model performance.
Effect of Plant Morphological Traits on Throughfall, Soil Moisture, and Runoff
Authors: Liu Yu , Zhao Liang
Published: June 2020

Plant canopy morphology plays an important role in water balance, peculiarly in semiarid environments. Through a field experiment, the impact of plant morphology of two native plant species, Artemisia sacrorum Ledeb (ASL) and Spiraea pubescens Turcz (SPT), on partitioning rainwater was revealed. The results indicated that a fragmented leaf shape and apparently high stem density of ASL reduced the throughfall and its intensity effectively but facilitated soil moisture replenishment. Although SPT has a greater canopy cover and canopy depth than ASL does, larger throughfall, a smaller throughfall threshold, and stronger throughfall intensity were observed in the SPT site. Moreover, the SPT site has a higher soil steady infiltration rate, but produced more surface runoff and caused lower soil moisture content. This study highlights the importance of plant morphological traits, peculiarly leaf morphology, in partitioning rainwater in this semiarid region. We argue that plant morphological traits should be considered when selecting plant species for revegetation and assessing water balance.
Assessment of Ecological and Hydro-Geomorphological Alterations under Climate Change Using SWAT and IAHRIS in the Eo River in Northern Spain
Authors: Pérez-Sánchez Julio , Senent-Aparicio Javier , Martínez Santa-María Carolina , López-Ballesteros Adrián
Published: June 2020

Magnitude and temporal variability of streamflow is essential for natural biodiversity and the stability of aquatic environments. In this study, a comparative analysis between historical data (1971–2013) and future climate change scenarios (2010–2039, 2040–2069 and 2070–2099) of the hydrological regime in the Eo river, in the north of Spain, is carried out in order to assess the ecological and hydro-geomorphological risks over the short-, medium- and long-term. The Soil and Water Assessment Tool (SWAT) model was applied on a daily basis to assess climate-induced hydrological changes in the river under five general circulation models and two representative concentration pathways. Statistical results, both in calibration (Nash-Sutcliffe efficiency coefficient (NSE): 0.73, percent bias (PBIAS): 3.52, R2: 0.74) and validation (NSE: 0.62, PBIAS: 6.62, R2: 0.65), are indicative of the SWAT model’s good performance. The ten climate scenarios pointed out a reduction in rainfall (up to −22%) and an increase in temperatures, both maximum (from +1 to +7 °C) and minimum ones (from +1 to +4 °C). Predicted flow rates resulted in an incrementally greater decrease the longer the term is, varying between −5% (in short-term) and −53% (in long-term). The free software IAHRIS (Indicators of Hydrologic Alteration in Rivers) determined that alteration for usual values remains between excellent and good status and from good to moderate in drought values, but flood values showed a deficient regime in most scenarios, which implies an instability of river morphology, a progressive reduction in the section of the river and an advance of aging of riparian habitat, endangering the renewal of the species.
Quality Control Development at the Strategic Level
Authors: Chandeth Lim , Shostakovska Antonina , Tsymbal Petro , Vlasova Ganna
Published: June 2020

The paper deals with the scientific and methodological approach to quality control of the industrial enterprise development at the strategic level based on adapting the control system to the life cycle stages of the organizational structure and products of the industrial enterprise, through which the transition between the stages of the life cycle and the quality of the enterprises’ development in a strategic term can be detected. In terms of the products’ life cycle, the task of control at the strategic level is to detect promptly the stage when the products no longer meet the needs of the market, and to control the transition efficiency from stage to stage. To solve this task, it is proposed to use the following indicators: the dynamics of sales volumes; the dynamics of the products’ market share; the coefficient of products’ competitiveness; the dynamics of products’ profitability; the coefficient of product expectation on the market, etc.
Chronic Hemodialysis Patients Hospitalized with COVID-19: Short-term Outcomes in the Bronx, New York
Authors: Fisher Molly , Yunes Milagros , Mokrzycki Michele H. , Golestaneh Ladan , Alahiri Emad , Coco Maria
Published: June 2020

Background

Patients with ESKD who are on chronic hemodialysis have a high burden of comorbidities that may place them at increased risk for adverse outcomes when hospitalized with COVID-19. However, data in this unique patient population are limited. The aim of our study is to describe the clinical characteristics and short-term outcomes in patients on chronic hemodialysis who require hospitalization for COVID-19.

Methods

We performed a retrospective study of 114 patients on chronic hemodialysis who were hospitalized with COVID-19 at two major hospitals in the Bronx from March 9 to April 8, 2020 during the surge of SARS-CoV-2 infections in New York City. Patients were followed during their hospitalization through April 22, 2020. Comparisons in clinical characteristics and laboratory data were made between those who survived and those who experienced in-hospital death; short-term outcomes were reported.

Results

Median age was 64.5 years, 61% were men, and 89% were black or Hispanic. A total of 102 (90%) patients had hypertension, 76 (67%) had diabetes mellitus, 63 (55%) had cardiovascular disease, and 30% were nursing-home residents. Intensive care unit (ICU) admission was required in 13% of patients, and 17% required mechanical ventilation. In-hospital death occurred in 28% of the cohort, 87% of those requiring ICU, and nearly 100% of those requiring mechanical ventilation. A large number of in-hospital cardiac arrests were observed. Initial procalcitonin, ferritin, lactate dehydrogenase, C-reactive protein, and lymphocyte percentage were associated with in-hospital death.

Conclusions

Short-term mortality in patients on chronic hemodialysis who were hospitalized with COVID-19 was high. Outcomes in those requiring ICU and mechanical ventilation were poor, underscoring the importance of end-of-life discussions in patients with ESKD who are hospitalized with severe COVID-19 and the need for heightened awareness of acute cardiac events in the setting of COVID-19. Elevated inflammatory markers were associated with in-hospital death in patients with ESKD who were hospitalized with COVID-19.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/K360/2020_08_27_KID0003672020.mp3.
ТЕОРЕТИКО-МЕТОДОЛОГІЧНІ ТА ІНФОРМАЦІЙНО-ТЕХНОЛОГІЧНІ АСПЕКТИ ВПРОВАДЖЕННЯ ДИСТАНЦІЙНОГО НАВЧАННЯ ТАКТИЧНИХ ДИСЦИПЛІН НА БАЗІ ПЛАТФОРМИ MOODLE В ОСВІТНІЙ ПРОЦЕС ВИЩОГО ВІЙСЬКОВОГО НАВЧАЛЬНОГО ЗАКЛАДУ
Authors: Зміївський Г. А. , Кочанов Е. О.
Published: June 2020

У статті на основі всебічного аналізу та узагальнення досвіду використання інформаційних технологій дистанційного навчання у закладах вищої освіти України, сформульовані підходи щодо їх впровадження в систему національної військової освіти. З’ясовано, що одним з головних напрямів використання інформаційних технологій для вдосконалення дистанційного навчання є розробка й упровадження персональних навчальних систем. Доведено, що найперспективнішою і такою, що отримала повсюдне поширення для створення персональних навчальних систем, є платформа Moodle. Внесено пропозиції з її адаптації в освітній процес вищого військового навчального закладу. Сформульовано рекомендації щодо технологічних етапів процесу дистанційного вивчення тактичних дисциплін. Звернено увагу на особливості розробки матеріалів, що розміщуються і циркулюють в системі. Висвітлені основні методологічні та інформаційно-технологічні аспекти використання персональних навчальних систем на базі платформи Moodle для організації та проведення навчальних занять з тактичних дисциплін. Визначені додаткові засоби навчання для підвищення ефективності цих занять.
ПУБЛІЧНИЙ ПРОСТІР: СТРУКТУРА ТА СКЛАДНИКИ, ЇХНІ ОЗНАКИ ТА ПРИНЦИПИ
Authors: Lukin  S. 
Published: June 2020

Розглянуто поняття “публічність”, “публічна сфера”, “публічний простір”. Проаналізовано основні принципи публічного простору як закономірності функціонування окремих складників, а саме: відкритості і прозорості, об’єктивності, демократії в управлінні містом, комфорту, екологічності, безпеки, розвитку освіти, технологічності, економічності, мобільності, культурології та ін., які утворюють ефективну систему функціонування міста. Подано модель “евклідового” публічного простору для підкреслення природи елементів та їхніх властивостей.
ОРГАНІЗАЦІЙНА ПІДТРИМКА РОЗВИТКУ ПІДПРИЄМНИЦТВА НА РЕГІОНАЛЬНОМУ РІВНІ
Authors: Lesnaya  O.
Published: June 2020

Охарактеризовано основні організації та установи, діяльність яких спрямовано на підтримку розвитку підприємництва на регіональному рівні, на прикладі Харківської області, мету діяльності, завдання, основні напрями діяльності та послуги, що надаються.
СУЧАСНА ДЕРЖАВНА ПОЛІТИКА РОЗВИТКУ ЦИФРОВОЇ ГРАМОТНОСТІ ПУБЛІЧНИХ СЛУЖБОВЦІВ ТА ГРОМАДЯН УКРАЇНИ
Authors: Zhyliaiev I. , Semenchenko A.
Published: June 2020

Запропоновано концептуальні засади розвитку цифрових навичок публічних службовців та громадян з метою подальшого  використання їх при формуванні та реалізації загальнодержавних, галузевих,  регіональних та місцевих концептуальних, стратегічних та програмних документів, спрямованих на розвиток в Україні сучасної цифрової економіки та інформаційного суспільства, які включають систему базових принципів, мету, етапи, стратегічні завдання, результати, що очікуються, основні форми навчання, підходи до визначення пріоритетного контингенту слухачів. Визначено основні фактори впливу, ризики реалізації цієї політики та механізм її коригування.
АДАПТАЦІЯ ІНСТИТУТУ ДЕРЖАВНОЇ СЛУЖБИ УКРАЇНИ ДО СТАНДАРТІВ ЄВРОПЕЙСЬКОГО СОЮЗУ
Authors: Trunina  I.  , Latyshev  K.  , Skrebcova  K. 
Published: June 2020

Визначено, що досягти злагодженої діяльності державних інститутів неможливо без висококваліфікованих управлінців, які здатні швидко реагувати на запити суспільства.

Проаналізовано основні принципи, на яких ґрунтується державна служба. Сформовано систему показників для оцінювання ефективності та особливостей розвитку державної служби в Україні, серед яких суттєвість показників та їхніх груп для державних органів влади, порівняльність показників, регулювання показників, прогнозування розвитку. За допомогою інтегрального показника та визначених показників, які віддзеркалюють організаційні та соціально-економічні аспекти розвитку державної служби на сучасному етапі демократизації державного управління, розраховано рівень розвитку державної служби в Україні станом на друге півріччя 2018 р.

Визначено необхідність створення єдиного документа-стандарту на основі посадових інструкцій державних службовців, професійно-кваліфікаційних характеристик посад, моделей компетентності тощо, адже існування низки законодавчих і підзаконних нормативних актів, які регулюють кадрові призначення у державній службі стримують процес становлення та розвитку державної служби.

Проаналізовано базові показники програми СІГМА, упровадження якої є важливим політичним кроком для України щодо забезпечення нової якості державного управління.

Доведено, що найбільш сприятливим методом інтеграції державної служби в Україні до стандартів ЄС є метод адаптації.
ПРАВОВЕ РЕГУЛЮВАННЯ ТА РЕАЛІЗАЦІЯ ДЕРЖАВНОЇ МОВНОЇ ПОЛІТИКИ СЛОВАЦЬКОЇ РЕСПУБЛІКИ ЩОДО УГОРСЬКОЇ ТА УКРАЇНСЬКОЇ НАЦІОНАЛЬНИХ МЕНШИН
Authors: Kovalyova  T. 
Published: June 2020

Розглянуто нормативно-правові акти Словаччини у сфері мовної політики та сучасний стан забезпечення мовних прав угорської та української національних меншин. Наголошується, що ефективності мовних відносин між Словаччиною та українською національною меншиною можна досягти шляхом застосування комунікаційних стратегій у спілкуванні урядових і неурядових організацій для забезпечення мовних прав національних меншин обох країн.
Abscission of Familial Bonding in Khaled Hosseini’s And the Mountains Echoed
Authors: Joy Hepzibah C
Published: June 2020

Adoption is a beautiful thing in the world when it comes to giving life to abandon children. But as said often, “The only guarantee if a child is adopted is trauma,” the same adoption is so brutal when the child has been separated from the living family members and given for adoption. There is no worse pain than the pain of the children being separated from their birth family. This research throws light on abscission from the familial cohesion because of the critical situations in the family. Here, in this study, a young child is abscissed from her own family by adoption. The permanent separation from her biological parents creates the feeling of separation and longingness in the novel, And the Mountains Echoed, written by Khaled Hosseini. Pari, is theadopted child, and the protagonist of the novel was in her immature age when she had been separated from her family. The importance of familial relationships is shown very deeply in this novel through the plight of the protagonist, Pari. After the years of separation, the same child who became a mature woman gets reunited with her brother. But the traumatic experience that she had undergone can never be undone.
ANALISIS TEOLOGIS MENGENAI BERIBADAH DI RUMAH DI TENGAH PANDEMI COVID-19 DI INDONESIA
Authors: Luhukay Alexander Stevanus
Published: June 2020

Kasus COVID-19 (virus corona) sudah menjadi pandemi global, secara khusus di Indonesia. Untuk memutus rantai penyebaran virus, pemerintah dan pimpinan gereja melakukan proses social distancing dengan menghimbau warga gereja melaksanakan ibadah di rumah masing-masing. Hal ini menimbulkan dilema di kalangan anggota jemaat karena selama ini mereka selalu beribadah di gereja. Mereka membutuhkan jawaban teologis apakah beribadah di rumah dapat diterima atau tidak. Penelitian ini bertujuan untuk memberikan jawaban tersebut. Metode yang digunakan adalah hermeneutika dengan pendekatan kritik teks dan kritik historis. Hasil penelitian adalah adalah bahwa pelaksanaan ibadah di rumah tidak mengurangi esensi ibadah itu sendiri, karena makna dari ibadah yang sejati adalah hidup manusia itu sendiri di hadapan Allah (Rm 12: 1-2). Dengan demikian sudah menjawab dilema yang terjadi mengenai penerapan ibadah di rumah saat pandemi COVID-19 di Indonesia.
Edge-facilitated Augmented Vision in Vehicle-to-Everything Networks
Authors: Zhou Pengyuan , Braud Tristan , Zavodovski Aleksandr , Liu Zhi , Chen Xianfu , Hui Pan , Kangasharju Jussi
Published: June 2020

IEEE Transactions on Vehicular Technology (accepted with minor revision)
Os comunistas brasileiros no compasso da política internacional entre a I e a II Guerra
Authors: Maia Rodrigo Ismael Francisco
Published: June 2020

In this article we seek to expose an overview of the performance of the Communists in Brazil, drawing a parallel between national and international policies followed by the Brazilian Communist Party (PCB), began in the period of the early twentieth century, when more organized actions occur within the working class, to the initial moment of the Cold War and the bourgeois military coup in Brazil. Thus, the article seeks to give an overview of the political and economic development of Brazil as a country agricultural export-oriented economy and politically characterized by a development of “prussian way”. The I and II World War, the Cold War, the influence of anarcho-syndicalism and the quest for democracy are some of the topics discussed here. We note that at any given time, following the foreign policy stream, the PCB is identified by the State as a national enemy, as well as the USSR and socialism are at the international level.
Concepções teóricas da contemporaneidade
Authors: Lemos Marcelo Rodrigues
Published: June 2020

Partindo de mudanças ocorridas na forma de organização social moderna, diversos estudos são desenvolvidos, dando às transformações práticas uma problematização teórica. Com isso, a proposta deste artigo é situar parte do debate acadêmico realizado pelas Ciências Sociais quanto à possibilidade de definição da contemporaneidade mediante o enfrentamento de teorias construídas pelos seguintes pensadores: Bauman, Giddens, Santos, Augé e Beck. Cada um deles, à sua maneira, reflete sobre a atualidade, destacando-a como uma fase específica da própria modernidade ou vendo-a como um novo tempo histórico. Assim, os conceitos modernidade líquida, alta modernidade, transição paradigmática, supermodernidade e sociedade de risco são forjados para a compreensão do presente.
GENERATION REGULARITIES OF VIBRATION AND NOISE SPECTRA OF THE GEARBOXES OF OVERHEAD TRAVELING CRANES
Authors: Bondarenko Veronika , Chukarin Alexander
Published: June 2020

The acoustic system of the overhead traveling cranes includes the following diverse sources of acoustical radiation: rails, wheel sets, a base frame, gears and motors of the lifting and moving mechanisms. The acoustic characteristics of the motors do not exceed the maximum permissible sound pressure levels. The gearboxes as the sources of noise and vibration are the most complicated units; moreover, they arrive at the manufacturing factories already being assembled. Therefore, when assessing the sound pressure levels of the cranes in whole, it is advisable to use the experimental data of the noise and gearbox vibration spectra.
REDUCING NOISE FROM ROUND WOODWORKING MACHINES BY APPLYING VIBRATION DAMPING FRICTION PADS BETWEEN THE SAW BLADE AND THE CLAMPING FLANGE
Authors: Osmolovsky Denis , Asminin Victor , Druzhinina Elena
Published: June 2020

Circular woodworking machines belong to one of the noisiest types of woodworking equipment (the noise level on a working cycle reaches 110-120 dBA). The dominating source of noise from circular woodworking machines on a working cycle is a saw disk owing to excitation of sound vibration in it. The means of the vibration-damping are the most radical and rational approach to noise reduction in an occurrence source (saw disk). The new unified construction of the device which consists of the vibration-damping frictional gaskets (with a dry friction VDPST) placed between a saw disk and a clamping flange circular of woodworking machines is offered. Crucial factor dissipation vibration energy in propose construction come out dry friction between minerals abrasive particles.
Saúde do trabalhador no ambiente hospitalar: fatores de risco para sí­ndrome de burnout
Authors: Natividade dos Santos Erick , Jefferson Silva de França ítalo , Lima Vilas Boas Ludmilla , Paes Miranda Avanilde
Published: June 2020

Conhecer os fatores de risco aos enfermeiros e técnicos de enfermagem no ambiente de trabalho que possibilite a ocorrência de Sí­ndrome de Burnout. Trata-se de um estudo analí­tico, observacional, com corte transversal, quantitativo. A coleta dedados foi realizada pelas pesquisadoras em uma Unidade de Terapia Intensiva com enfermeiros e técnicos de enfermagem, no perí­odo de novembro a dezembro/2017. A amostra contemplou 100% profissionais, foi realizado com profissionais lotados. Observa-se que 79,17% tem idade entre 20 a 30 anos incompletos, 100% são do sexo feminino. A maioria referiram sempre apresentar sintomas í  sí­ndrome de burnout, assim como, sintomas somáticos segundo Maslach Burnout Iventory que afirmaram apresentar í s vezes. o desafio da promoção da saúde no trabalho e da prevenção do burnout, torna-se ainda maior na medida em que é exigido um diálogo permanente entre o planejamento, a execução e gestão.
Aleitamento materno: a visão de puérperas soropositivas para HIV e HTLV quanto a não amamentação
Authors: Neves Lima Camila , Pimenta de Moraes Lilia , Cristhina Lobato Jardim Rêgo Héllen
Published: June 2020

O aleitamento materno é o mais simples método de ví­nculo, proteção e nutrição para a criança. Entretanto, o aleitamento pode ser contraindicado nos casos em que a puérpera possuir soropositividade para o HIV e HTLV. Objetivo: Conhecer a visão da puérpera soropositiva para HIV e HTLV quanto a não amamentação. Método: Descritivo com abordagem qualitativa, pois propiciaconhecer a natureza e processo que constitui o objeto de estudo, descrevendo-os e interpretando-os. Enquanto que a abordagem qualitativa possibilitará compreender a realidade estudada. Realizado em um hospital materno-infantil referência em gestação de alto risco. Participaram oito puérperas soropositivas para HIV/HTLV no perí­odo de março-abril de 2017. Resultado: Três categorias: entendimento relacionado ao não aleitamento materno; sentimento da puérpera quanto a não amamentação e conhecimento sobre o funcionamento e importância do banco de leite humano. Considerações finais: Pode-se compreender a visão da puérpera sobre o aleitamento materno, falta de conhecimento das participantes advindas do interior e falta de informações quanto ao HTLV, salientando a importância da interação entre a enfermagem e a puérpera a fim de melhor orientá-la.
Saúde e educação: uma parceria necessária a inclusão da criança autista
Authors: S. Sena Lima da Silva Carine , Maia Leonardo , Melo de Castro Flavia , Fornaciari Princielle , Hlade Vasconcelos Ana Paula , Soares de Andrade Lidiane , Dávila da Silva Polyana , Soares da Silva Thamires , Paixão Costa Juvanice , Lima Damasceno Simone , Martins da Silva Dheisy , De Souza Kanenberg Francisco José
Published: June 2020

Este estudo teve como objetivo realizar uma revisão da literatura nacional e internacional quanto a artigos de periódicos cientí­ficos sobre a inclusão escolar de crianças com Transtorno do Espectro Autista (TEA), atentando-se para o perí­odo e o periódico, os temas investigados e suas metodologias. Foram selecionados 16 estudos nas bases LILACS e SciELO, publicados entre 2012 e 2017. As pesquisas nacionais e internacionais foram agrupadas de acordo com os temas de investigação e os seus objetivos. A maioria dos estudos localizados caracterizou-se como empí­rico e de abordagem qualitativa. De modo geral, a revisão da literatura realizada possibilitou o resgate de experiências sobre a inclusão escolar de crianças com TEA, além de esboçar um breve panorama dos principais temas que estão sendo investigados.
Cuidar dos cuidadores: a percepção do estresse pelo residente de enfermagem
Authors: Corrêa Vallois Elisabete , Costa Rosa Andrade Silva Rose Mary , Ramos Pereira Eliane , Yolanda Bueno Bejarano Vale de Medeiros Angélica , Ribeiro Chí­charo Sandra Conceição , Da Silva Pinto Carneiro Eliane Cristina
Published: June 2020

Objetiva-se compreender a percepção do residente de enfermagem acerca do estresse em sua atividade laboral. Estudo descritivo com abordagem qualitativa. Os dados foram coletados por meio de entrevistas com a participação de 10 Residentes de Enfermagem de um hospital de referência. Para interpretação dos resultados, utilizou se o método fenomenológico de Amadeo Giorgi e referencial teórico de Merleau Ponty. Os residentes relataram que percebem o estresse como algo presente em suas atividades. Compreendemos então a importância da preparação desse profissional para o desenvolvimento de atitudes de enfrentamento, diante í s diversas situações no local de trabalho, respeitando a singularidade e percepção de cada um. Os resultados fomentaram reflexões e a compreensão fenomenológica do cotidiano dos residentes, e a partir do conhecimento de suas experiências sugere-se o resgate da do cuidado integral também para quem está cuidando. Estratégias para melhorar a qualidade de vida no trabalho dos residentes são necessárias.
Qualidade de vida de idosos com Alzheimer: um estudo de correlação
Authors: Da Costa de Assis Cí­ntia Raquel , Leite Funchal Camacho Alessandra Conceição , Santos de Queiroz Raquel , Nascimento de Andrade Giselle , Lí­rio Gurgel Jonas
Published: June 2020

Objetiva-se correlacionar a percepção da qualidade de vida do idoso com Doença de Alzheimer com a percepção de seus cuidadores e identificar o perfil sociodemográfico dos idosos. Estudo correlacional com abordagem quantitativa, com 34 idosos com Doença de Alzheimer leve e/ou moderado e seus cuidadores, durante as consultas de enfermagem, utilizando-se um questionário sociodemográfico e escala de Avaliação da Qualidade de Vida na Doença de Alzheimer. Os idosos apontaram como negativas (ruim e regular) memória (55,9%), em ambos com maior percentual; positivas (bom e excelente), moradia (91,2%), respectivamente e seus cuidadores como negativas (ruim e regular) memória (61,8%) e disposição (64,7%), e positivas (bom e excelente) moradia (61,8%) e famí­lia (29,4%), respectivamente. Conclui-se que os idosos com comprometimento cognitivo apresentam uma boa percepção de sua  qualidade de vida, evidenciando um dos principais itens negativos, a memória.
O familiar de crianças oncológicas e sua qualidade de vida: revisão integrativa
Authors: Assis Cí­ntia Raquel da Costa de , V Claudemir Santos de , Silva Janaí­na Carneiro de Souza da , Peregrino Antonio , Augusto Patrí­cia Soares , Silva Carine Silvestrini Sena Lima
Published: June 2020

Objetiva-se analisar as publicações acerca da qualidade de vida do familiar de crianças oncológicas. Trata-se de uma revisão integrativa, com abordagem qualitativa, entre os anos de 2013 a 2017, por meio dos referidos banco de dados da Biblioteca Virtual de Saúde. Foram selecionados 17 artigos, dos quais foram divididos em unidades temáticas: a famí­lia no ambiente hospitalar, familiar x Criança com câncer, atuação do enfermeiro com criança com câncer. Diante dos achados referentes as unidades emergidas, verifica-se que existem poucos estudos referentes a categoria qualidade de vida deste familiar e que a hospitalização para os responsáveis reflete um sentimento de angústia, ansiedade e culpa, entretanto tendo que aprender a conviver junto de seu filho com o câncer. A pesquisa possibilitou uma ampla demonstração das etapas vivenciadas por um familiar com uma criança oncológica, o medo e incerteza ao enfrentar uma hospitalização por inúmeros dias ou meses com rotinas hospitalares, afastamento social e familiar, além de í­ndices baixos de qualidade de vida desses cuidadores.
Competências Pedagógicas do enfermeiro professor na graduação em enfermagem
Authors: Regina Lins do Prado Tardelli da Silva Sandra , Pazetto Balsanelli Alexandre , Ribeiro Neves Vanessa
Published: June 2020

Objetivo: Identificar as competências pedagógicas necessárias ao enfermeiro para o exercí­cio da docência nos cursos degraduação em enfermagem. Método: revisão integrativa. Resultados: A amostra foi composta por 10 artigos que destacaram como competências: conhecimento sobre o que ensina; familiaridade com os processos administrativos da escola; criatividade; inovação; curiosidade; empatia; entusiasmo; bom relacionamento; comunicação efetiva e eficaz; habilidades para realizar técnicas, supervisão, registros, avaliações e planejamento. A qualidade metodológica dos estudos foi relevante. Conclusão: Identificou-se diferentes referenciais teóricos para conceituar competências e a ausência de uma matriz que fundamente a formação e avaliação docente. Sugere-se que novos estudos possam ser realizados criando e validando instrumentos com essa proposta.
O cuidado familiar da criança com anemia falciforme
Authors: Gravina Fortini Rafael , Maria Sabóia Vera , De Freitas Gomes Denildo , Milton Oliveira Ferreira Antônio
Published: June 2020

Trata-se de um estudo que aborda o conhecimento e as medidas adotadas por familiares de crianças que vivem com anemiafalciforme, na prevenção da crise falcêmica. Objetivos: identificar o conhecimento sobre a doença falciforme na criança e descrever ações desses familiares na prevenção da crise falcêmica. Método: estudo quantitativo, os participantes foram os familiares dessas crianças. Foi utilizado um formulário de entrevista estruturada. Resultados: os familiares possuem conhecimentos significativos sobre a patologia, bem como sobre as medidas de prevenção da crise falcêmica. Quanto ao conhecimento das medidas de prevenção da crise falcêmica, constatou-se um percentual de acerto que girou em torno de 60% a 80%, percentual este, considerado significativo. Conclusão: face ao caráter educador da formação do enfermeiro, acreditamos ser imprescindí­vel sua participação na equipe de atendimento í  criança com anemia falciforme, o que certamente contribuirá para a efetiva mudança de hábito e estilo de vida dessa criança.
Carga de trabalho da enfermagem influenciando a ocorrência e redução de lesões por pressão
Authors: Sanchez Bosco Priscila , Silva Martins Mônica
Published: June 2020

Objetiva-se descrever a carga de trabalho da enfermagem e compreender sua relação com a ocorrência ou não de lesãopor pressão. Trata-se de um estudo observacional, transversal e prospectivo com abordagem mista, voltado para descrever a carga de trabalho da enfermagem e compreender sua relação com a ocorrência ou não de lesão por pressão em pacientes internados em dois hospitais públicos, um hospital federal especializado e outro universitário. Para tanto, realizou-se a observação, descrição e análise da dinâmica de trabalho e interação entre a equipe de enfermagem e os pacientes internados. Espera-se que a carga de trabalho de enfermagem e a incidência e prevalência de lesão por pressão estejam diretamente relacionadas.