bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of autosomal and male DNA extracted from casework samples using Casework Direct Kit, Custom and Maxwell 16 System DNA IQ Casework Pro Kit for autosomal-STR and Y-STR profiling
Authors: Hakim Hashom Mohd , Khan Hussein Omar , Ismail Siti Afifah , Ayob Shahrizad , Lalung Japareng , Kofi Edward Abban , Chambers Geoffrey Keith , Edinur Hisham Atan
Published: October 2019

Short repetitive regions in autosomal and Y chromosomes known as short tandem repeats (STRs) are currently used for DNA profiling in crime investigations. However, DNA profiling requires a sufficient quality and quantity of DNA template, which is often not obtained from trace evidence or degraded biological samples collected at the scene of a crime. Here, we assessed autosomal and male DNA components extracted from crime scene and mock casework samples using the Casework Direct Kit, Custom and compared the results against those obtained by extraction of matching samples using well-established Maxwell 16 System DNA IQ Casework Pro Kit. The quantity and quality of extracted DNA obtained using both Casework Direct Kit, Custom and Maxwell 16 System DNA IQ Casework Pro Kit were analyzed using PowerQuant Systems followed by autosomal and Y-chromosome STR profiling using GlobalFiler Express PCR Amplification Kit and PowerPlex Y23 System, respectively. Our results showed that the Casework Direct Kit and Maxwell 16 DNA IQ Casework Pro Kit have more or less equal capacity to extract inhibitor free DNA, but that the latter produces slightly better quality and more DNA template and subsequently higher numbers of STR allele calls for autosomal and Y-STR analyses. Nonetheless, the Casework Direct Kit, Custom is the quicker and cheaper option for extraction of good, clean DNA from high content material and might best be used for extraction of reference samples. Such reference DNA samples typically come from buccal swabs or freshly drawn blood. So, in general, they can confidently be expected to have a high nucleic acid content and to be inhibitor-free.
Rare earth ion Tb3+ doped natural sodium feldspar (NaAlSi3O8) Luminescent properties and energy transfer
Authors: Halmurat Dilare , Yusufu Taximaiti , Wang Qing-ling , He Jiuyang , Sidike Aierken
Published: October 2019

In this study, Tb3+—doped natural sodium feldspar (NaAlSi3O8) phosphors have been successfully prepared using high−temperature solid—state method with natural sodium feldspar as a substrate. Energy—dispersive X—ray spectrometry analysis (EDX) of NaAlSi3O8 showed that 0.03 wt% of Eu element was present, and elemental distribution mapping analysis showed that the distribution of trace Eu in minerals was aggregated. The crystal structure and luminescence properties of the natural sodium Eu—containing feldspar and synthetic sodium feldspar NaAlSi3O8:Eu3+, Tb3+ phosphors are discussed in detail. The crystal structure analysis of the samples showed that the Na+ in the natural matrix was partly replaced by the doped Tb3+. Studies on the photoluminescence properties of the samples indicate that Eu does not form a luminescent center in the natural mineral, however, the strong characteristic peak of Eu3+ at 615 nm appears after doping with Tb3+ and the peak at 615 nm increases with the increase of Tb3+ concentration. According to the above spectral results, the energy transfer from Tb3+ to Eu3+ is obtained. Through the measurement and analysis of color coordinates, it is found that with the increase of Tb3+ concentration, the luminescence color of the samples can be regulated in the green to red region. NaAlSi3O8:Eu3+ Tb3+ phosphors has potential application value.
Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance
Authors: Stsiapanava Alena , Selmer Maria
Published: October 2019

Pathogens often receive antibiotic resistance genes through horizontal gene transfer from bacteria that produce natural antibiotics. ErmE is a methyltransferase (MTase) from Saccharopolyspora erythraea that dimethylates A2058 in 23S rRNA using S-adenosyl methionine (SAM) as methyl donor, protecting the ribosomes from macrolide binding. To gain insights into the mechanism of macrolide resistance, the crystal structure of ErmE was determined to 1.75 Å resolution. ErmE consists of an N-terminal Rossmann-like α/ß catalytic domain and a C-terminal helical domain. Comparison with ErmC’ that despite only 24% sequence identity has the same function, reveals highly similar catalytic domains. Accordingly, superposition with the catalytic domain of ErmC’ in complex with SAM suggests that the cofactor binding site is conserved. The two structures mainly differ in the C-terminal domain, which in ErmE contains a longer loop harboring an additional 310 helix that interacts with the catalytic domain to stabilize the tertiary structure. Notably, ErmE also differs from ErmC’ by having long disordered extensions at its N- and C-termini. A C-terminal disordered region rich in arginine and glycine is also a present in two other MTases, PikR1 and PikR2, which share about 30% sequence identity with ErmE and methylate the same nucleotide in 23S rRNA.
Curvature induction and sensing of the F-BAR protein Pacsin1 on lipid membranes via molecular dynamics simulations
Authors: Mahmood Md. Iqbal , Noguchi Hiroshi , Okazaki Kei-ichi
Published: October 2019

F-Bin/Amphiphysin/Rvs (F-BAR) domain proteins play essential roles in biological processes that involve membrane remodelling, such as endocytosis and exocytosis. It has been shown that such proteins transform the lipid membrane into tubes. Notably, Pacsin1 from the Pacsin/Syndapin subfamily has the ability to transform the membrane into various morphologies: striated tubes, featureless wide and thin tubes, and pearling vesicles. The molecular mechanism of this interesting ability remains elusive. In this study, we performed all-atom (AA) and coarse-grained (CG) molecular dynamics simulations to investigate the curvature induction and sensing mechanisms of Pacsin1 on a membrane. From AA simulations, we show that Pacsin1 has internal structural flexibility. In CG simulations with parameters tuned from the AA simulations, spontaneous assembly of two Pacsin1 dimers through lateral interaction is observed. Based on the complex structure, we show that the regularly assembled Pacsin1 dimers bend a tensionless membrane. We also show that a single Pacsin1 dimer senses the membrane curvature, binding to a buckled membrane with a preferred curvature. These results provide molecular insights into polymorphic membrane remodelling.
Development and validation of a prognostic nomogram for predicting post-operative pulmonary infection in gastric cancer patients following radical gastrectomy
Authors: Xiao Haifan , Zhou Huijun , Liu Ke , Liao Xianzhen , Yan Shipeng , Yin Bin , Ouyang Yongzhong , Xiao Hua
Published: October 2019

The aim of this retrospective study was to develop and validate a nomogram for predicting the risk of post-operative pulmonary infection (POI) in gastric cancer (GC) patients following radical gastrectomy. 2469 GC patients who underwent radical gastrectomy were enrolled, and randomly divided into the development and validation groups. The nomogram was constructed based on prognostic factors using logistic regression analysis, and was internally and crossly validated by bootstrap resampling and the validation dataset, respectively. Concordance index (C-index) value and calibration curve were used for estimating the predictive accuracy and discriminatory capability. Sixty-five (2.63%) patients developed POI within 30 days following surgery, with higher rates of requiring intensive care and longer post-operative hospital stays. The nomogram showed that open operation, chronic obstructive pulmonary disease (COPD), intra-operative blood transfusion, tumor located at upper and/or middle third and longer operation time (≥4 h) in a descending order were significant contributors to POI risk. The C-index value for the model was 0.756 (95% CI: 0.675−0.837), and calibration curves showed good agreement between nomogram predictions and actual observations. In conclusion, a nomogram based on these factors could accurately and simply provide a picture tool to predict the incidence of POI in GC patients undergoing radical gastrectomy.
Characterization of canine anti-mouse antibodies highlights that multiple strategies are needed to combat immunoassay interference
Authors: Bergman Daniel , Larsson Anders , Hansson-Hamlin Helene , Åhlén Emma , Holst Bodil Ström
Published: October 2019

Immunoassays are widely used for detection and quantification of analytes in biological samples, but are vulnerable to analytical errors caused by interfering sample substances. Of particular interest are endogenous anti-animal antibodies that may bind to the immunoassay antibodies and cause erroneous test results. This phenomenon is a hazard to patient safety in both human and veterinary medicine. Here, we demonstrate that anti-mouse antibodies in dogs bind selectively to different regions of the murine IgG molecule, cross-react with IgG from different species, and consist of all major antibody classes present in canine serum (IgA, IgG and IgM). The antibody characteristics varied among individuals and their prevalence differed between two dog breeds. The selective binding to different IgG regions suggests that the antibodies might not originate from immunization through exposure to mice or other species. These findings show that canine anti-mouse antibodies are highly heterogeneous in nature and therefore require a combination of strategies to be counteracted.
Hydrophilic and degradable polyesters based on l-aspartic acid with antibacterial properties for potential application in hernia repair
Authors: Han Hua , Zhu Jie , Zhang Fang-Fang , Li Fa-Xue , Wang Xue-Li , Yu Jian-Yong , Qin Xiao-Hong , Wu De-Qun
Published: October 2019

A polyester hernia patch has received extensive attention in mesh hernia repair.
Chemical anchoring of SeS2on a fluoro-substituted covalent organic framework as a high-performance cathode material
Authors: Wang De-Gao , Wang Yunyan , Song Min , Kuang Gui-Chao , Han Kai
Published: October 2019

SeS2is chemically anchored on a fluoro-substituted covalent organic framework and exhibits high electrochemical performance.
The effect of long-range order on intermolecular interactions in organic semiconductors: zinc octaethyl porphyrin molecular thin film model systems
Authors: Kumar A. , Naumenko D. , Rossi G. , Magnano E. , Nappini S. , Bondino F. , Segoloni E. , Amidani L. , d’Acapito F. , Boscherini F. , Barba L. , Pace E. , Benfatto M. , Casassa S. , Pedio M.
Published: October 2019

Influence of the ZnOEP thin film growth procedure on molecular orientation, crystalline molecular packing and on intermolecular interactions.
Defects on a pyrite(100) surface produce chemical evolution of glycine under inert conditions: experimental and theoretical approaches
Authors: Galvez-Martinez Santos , Escamilla-Roa Elizabeth , Zorzano Maria-Paz , Mateo-Marti Eva
Published: October 2019

The presence of non-stoichiometric sites on the pyrite(100) surface makes it a suitable substrate for driving the chemical evolution of the amino acid glycine over time, even under inert conditions.
Anion binding to mutants of the Schiff base counterion in heliorhodopsin 48C12
Authors: Singh Manish , Katayama Kota , Béjà Oded , Kandori Hideki
Published: October 2019

The anion binds as the direct H-bonding acceptor of the Schiff base in E107A, while E107Q indirectly accommodates an anion.
Activity–crowding coupling effect on the diffusion dynamics of a self-propelled particle in polymer solutions
Authors: Yuan Chengli , Chen Anpu , Zhang Bingjie , Zhao Nanrong
Published: October 2019

The anomalous diffusion dynamics of an active particle in polymer solutions is studied based on a Langevin Brownian dynamics simulation.
Altering the optoelectronic properties of boron difluoride formazanate dyesviaconjugation with platinum(ii)-acetylides
Authors: Dhindsa Jasveer S. , Melenbacher Adyn , Barbon Stephanie M. , Stillman Martin J. , Gilroy Joe B.
Published: October 2019

The absorption, emission, and electrochemical properties of conjugates of boron difluoride formazanate dyes and Pt(ii)-acetylides are systematically studied.
Bioaccessibility and stability of β-carotene encapsulated in plant-based emulsions: impact of emulsifier type and tannic acid
Authors: Li Ruyi , Tan Yunbing , Dai Taotao , Zhang Ruojie , Fu Guiming , Wan Yin , Liu Chengmei , McClements David Julian
Published: October 2019

The effect of two plant-based emulsifiers (quillaja saponin, QS and gum arabic, GA) and a polyphenol (tannic acid) on the formation, stability, digestibility, and β-carotene (BC) bioaccessibility of flaxseed oil-in-water emulsions was investigated.
Drug-induced skin toxicity: gaps in preclinical testing cascade as opportunities for complex in vitro models and assays
Authors: Hardwick Rhiannon N. , Betts Catherine J. , Whritenour Jessica , Sura Radhakrishna , Thamsen Maike , Kaufman Elad H. , Fabre Kristin
Published: October 2019

Selected skin MPS features desired to advance further adoption within the pharmaceutical industry.
The molecular mechanisms underlying mussel adhesion
Authors: Li Yiran , Cao Yi
Published: October 2019

Marine mussels are able to firmly affix on various wet surfaces by the overproduction of special mussel foot proteins (mfps).
Novel anti-HER2 peptide-conjugated theranostic nanoliposomes combining NaYF4:Yb,Er nanoparticles for NIR-activated bioimaging and chemo-photodynamic therapy against breast cancer
Authors: Panikar Sandeep Surendra , Ramírez-García Gonzalo , Vallejo-Cardona Alba A. , Banu Nehla , Patrón-Soberano Olga A. , Cialla-May Dana , Camacho-Villegas Tanya A. , de la Rosa Elder
Published: October 2019

Ligand-targeted multifunctional nanoliposome combining NaYF4:Yb,Er nanoparticles for NIR-activated bioimaging and chemo-photodynamic therapy against HER2 positive breast cancer.
All-inorganic perovskite CsPbBr3 microstructures growth via chemical vapor deposition for high-performance photodetectors
Authors: Mo Xindi , Li Xing , Dai Guozhang , He Pei , Sun Jia , Huang Han , Yang Junliang
Published: October 2019

Perovskite cesium lead halide (CsPbBr3) has attracted considerable attention due to its excellent optoelectronic properties and superior stability against moisture, oxygen, light, and heat.
Plant-derived chlorophyll derivative loaded liposomes for tri-model imaging guided photodynamic therapy
Authors: Zhou Hailin , Xia Lu , Zhong Jing , Xiong Saisai , Yi Xuan , Chen Lei , Zhu Ran , Shi Quanliang , Yang Kai
Published: October 2019

In this work, a liposome-encapsulated chlorophyll derivative pyropheophorbide acid (PPa) (liposome/PPa) nanoparticles are designed for tri-model imaging guided photodynamic therapy (PDT) of cancer.
Intestinal oligopeptide transporter PepT1-targeted polymeric micelles for further enhancing the oral absorption of water-insoluble agents
Authors: Jin Yao , Liu Qi , Zhou Chuhang , Hu Xinping , Wang Leqi , Han Shidi , Zhou Yuanhang , Liu Yan
Published: October 2019

Intestinal transporter PepT1-targeted polymeric micelles were fabricated as nanocarriers for further enhancing the oral absorption of water-insoluble agentsviaPepT1-mediated transcytosis.
Full color generation with Fano-type resonant HfO2 nanopillars designed by a deep-learning approach
Authors: Hemmatyar Omid , Abdollahramezani Sajjad , Kiarashinejad Yashar , Zandehshahvar Mohammadreza , Adibi Ali
Published: October 2019

Here, for the first time to our knowledge, a Fano resonance metasurface made of HfO2 is experimentally demonstrated to generate a wide range of colors. We use a novel deep-learning technique to design and optimize the metasurface.
Improving heat transfer in fused deposition modeling with graphene enhances inter filament bonding
Authors: Rostom Sahar , Dadmun Mark D.
Published: October 2019

Creating polymeric materials with high thermal conductivity provides pathways to tailor the thermal transport of the 3D printed object during printing, effectively controlling heat transfer and offering a rational method to optimize properties.
Visible light photocatalytic water oxidation over complex perovskites Sr3BNb2O9 (B = Mg, Ca and Sr) doped with nitrogen
Authors: Wang Ran , Lin Guoan , Xu Xiaoxiang
Published: October 2019

Large Sr cations at B site favor higher nitrogen uptake and surface hydrophilicity, being responsible for the high photocatalytic activity for water oxidation reactions.
The effects of Bi2O3 on the selective catalytic reduction of NO by propylene over Co3O4 nanoplates
Authors: Yu Dezhong , Zhong Xin , Liu Dong , Liang Ying
Published: October 2019

Bi2O3/Co3O4 catalysts prepared by the impregnation method were investigated for the selective catalytic reduction of NO by C3H6 (C3H6-SCR) in the presence of O2.
The β-cyclodextrin-modified nanosized ZSM-5 zeolite as a carrier for curcumin
Authors: Amani Shahin , Bagheri Garmarudi Amir , Rahmani Niloofar , Khanmohammadi Mohammadreza
Published: October 2019

Herein, the nanosized ZSM-5 zeolite was synthesized based on a fractional factorial experimental design by a hydrothermal method to study the optimum conditions for the synthesis and formation of the ZSM-5 zeolite by employing different conditions.
A N-doped graphene–cobalt nickel sulfide aerogel as a sulfur host for lithium–sulfur batteries
Authors: Wu Ping , Hu Hai-Yan , Xie Ning , Wang Chen , Wu Fan , Pan Ming , Li Hua-Fei , Wang Xiao-Di , Zeng Zheling , Deng Shuguang , Dai Gui-Ping
Published: October 2019

Herein, three-dimensional (3D) N-doped reduced graphene oxide (N-rGO) nanosheets were decorated with a uniform distribution of Co–Ni–S (CNS) nanoparticles to form the CNS/N-rGO composite as a sulfur host material for lithium–sulfur batteries.
A novel fluorescent off–on probe for the sensitive and selective detection of fluoride ions
Authors: Li Lihong , Zhang Min , Chang Kaijing , Kang Yu , Ren Guodong , Hou Xiaoyu , Liu Wen , Wang Haojiang , Wang Bin , Diao Haipeng
Published: October 2019

A sensitive and selective fluorescent off–on probe is developed for fluoride ion detection, and its applicability has been demonstrated by determining fluoride ions in real-water samples and toothpaste samples.
Axially chiral 1,4-dihydropyridine derivatives: aggregation-induced emission in exciplexes and application as viscosity probes
Authors: Yang Zeren , Huo Yanmin , Liu Yanke , Du Guifen , Zhang Wenhao , Zhou Lijie , Zhan Lihui , Ren Xuerui , Duan Wenzeng , Gong Shuwen
Published: October 2019

Axially chiral 1,4-dihydropyridine derivatives ((R)-/(S)-2) with aggregation-induced emission (AIE) in exciplex were designed and synthesized. They have excellent CD signals and can determine the different viscosity in mixed solvents.
Slurry nebulisation ICP-MS direct determination of high field strength elements (Nb, Ta, Zr, and Hf) in silicate rocks
Authors: Tong Rui , Guo Wei
Published: October 2019

A simple, rapid, and reliable method based on slurry nebulisation inductively coupled plasma mass spectrometry (ICP-MS) was developed for the direct determination of four high field strength elements (HFSEs, namely, Nb, Ta, Zr, and Hf) in refractory silicate rocks.
Three chiral one-dimensional lanthanide–ditoluoyl-tartrate bifunctional polymers exhibiting luminescence and magnetic behaviors
Authors: Han Mei-rong , Zhang Han-tao , Wang Jia-nan , Feng Si-si , Lu Li-ping
Published: October 2019

Self-assembly of three chiral one-dimensional Ln-CPs with luminescence and magnetic behaviors.
Formation of submicron-sized silica patterns on flexible polymer substrates based on vacuum ultraviolet photo-oxidation
Authors: Wu Cheng-Tse , Soliman Ahmed I. A. , Utsunomiya Toru , Ichii Takashi , Sugimura Hiroyuki
Published: October 2019

Patterned surface treatment on a polymer substrate is carried out by 172 nm VUV through a photomask. TMCTS pattern formation is guided by the resulting affinity-pattern. The secondary VUV treatment converted TMCTS patterns into silica patterns.
A comparative evaluation of calix[4]arene-1,3-crown-6 as a ligand for selected divalent cations of radiopharmaceutical interest
Authors: Bauer David , Blumberg Markus , Köckerling Martin , Mamat Constantin
Published: October 2019

The stability constants of the promising ligand calix[4]arene-1,3-crown-6 and divalent metals of radiopharmaceutical interest: lead, barium, and strontium, were determinedviaNMR and UV/Vis techniques.
Isomorphism combined with intercalation methods to construct a hybrid electrode material for high-energy storage capacitors
Authors: Sun Taotao , Yue Liguo , Wu Ning , Xu Mengni , Yang Wenhu , Guo Hao , Yang Wu
Published: October 2019

High-performance electrode materials were obtained by isomorphism and intercalation methods, resulting in multi-types of redox reaction centers and a bridge for charge transfer.
High-efficiency non-halogenated solvent processable polymer/PCBM solar cells via fluorination-enabled optimized nanoscale morphology
Authors: Rasool Shafket , Hoang Quoc Viet , Van Vu Doan , Trang Bui Thi Thu , Jin Seon-Mi , Ho Thuy Thi , Song Chang Eun , Lee Hang Ken , Lee Sang Kyu , Lee Jong-Cheol , Moon Sang-Jin , Lee Eunji , Shin Won Suk
Published: October 2019

The fullerene-based PSCs based on novel PNTz4T-1F polymer processed from a halogen-free solvent system demonstrated an outstanding PCE of 11.77% due to the optimum molecular ordering/packing and morphology.
Metal oxide patterns of one-dimensional nanofibers: on-demand, direct-write fabrication, and application as a novel platform for gas detection
Authors: Lim Kyeorei , Jo Young-Moo , Yoon Ji-Wook , Lee Jong-Heun
Published: October 2019

On-demand, direct-write fabrication of metal oxide patterns composed of one-dimensional nanofibers using near-field electrospinning is demonstrated and their formation mechanism as well as potential applications are investigated.
Precise control of apoptosis via gold nanostars for dose dependent photothermal therapy of melanoma
Authors: Xu Peng , Ning Peng , Wang Jingjing , Qin Yao , Liang Feng , Cheng Yu
Published: October 2019

Precise induction and monitoring of cell apoptosis are significant for cancer treatment.
Tuning the surface charge density of exfoliated thin molybdenum disulfide sheets via non-covalent functionalization for promoting hydrogen evolution reaction
Authors: Huang Wei-Ming , Liao Wei-Sheng , Lai Yan-Ming , Chen I-Wen Peter
Published: October 2019

The surface charge density of exfoliated monolayer molybdenum disulfide sheets can be successfully tuned with the assistance of exfoliants. As the surface charge potential approaches zero, the Tafel slope reaches 45 mV dec−1.
MiR-760 enhances sensitivity of pancreatic cancer cells to gemcitabine through modulating Integrin β1
Authors: Yang Dejun , Hu Zunqi , Xu Jiapeng , Tang Yuan , Wang Yu , Cai Qingping , Zhu Zhenxin
Published: October 2019

Pancreatic cancer (PC) is the most lethal tumor type among human diseases, with low survival rate. The investigation of potent molecular mechanisms involved in PC is still obscure owing to its drug resistance. The purpose of the present study is to disclose the underlying mechanism participating in PC progression and drug therapy, reversing the unpromising treatment outcome. In our research, microRNA-760 (miR-760) was first revealed to be lowly expressed in PC cells. And up-regulation of miR-760 could further suppress PC cell proliferation and boost cell apoptosis, as well as improve gemcitabine sensitivity of PC cells through gain-of-function assays. Besides, RNA-binding protein (RBP) MOV10 interacted with and stabilized Integrin β1 (ITGB1). Furtherly, miR-760 was proved to target Moloney leukemia virus 10 (MOV10) mRNA to decrease MOV10 protein expression, thus promoting the destabilization of ITGB1. At last, rescue experiments validated that up-regulation of ITGB1 remedied the miR-760 overexpression-caused inhibition on biological activities and gemcitabine resistance of PC cells. To summarize, the current inspection demonstrated that miR-760 enhances sensitivity of PC cells to gemcitabine through modulating MOV10-stablized ITGB1, highlighting the role of miR-760/MOV10/ITGB1 pathway in the drug therapy for PC patients.
The Impact of Dose and Dose Frequency on Word Learning by Kindergarten Children With Developmental Language Disorder During Interactive Book Reading
Authors: Storkel Holly L. , Komesidou Rouzana , Pezold Mollee J. , Pitt Adrienne R. , Fleming Kandace K. , Romine Rebecca Swinburne
Published: October 2019

Purpose

The goal was to determine whether interactive book reading outcomes for children with developmental language disorder (DLD) were affected by manipulation of dose (i.e., the number of exposures to the target word during a book reading session) and dose frequency (i.e., the number of repeated book reading sessions) and whether pretreatment factors predicted treatment response variation.

Method

Thirty-four kindergarten children with DLD (aged 5;0–6;2 [years;months]) were taught 1 set of words using the Dose 6 and Dose Frequency 6 format from a prior study (
Storkel, Voelmle, et al., 2017
) and taught a different set of words using an alternative format, either Dose 4 × Dose Frequency 9 or Dose 9 × Dose Frequency 4, determined through random assignment. Word learning was tracked for each treatment via a definition task prior to, during, and after treatment.

Results

Results showed that children with DLD learned a significant number of words during treatment regardless of the dose and dose frequency format but that significant forgetting of newly learned words occurred in all formats once treatment was withdrawn. Individual differences in word learning were related to Clinical Evaluation of Language Fundamentals Core Language and Understanding Spoken Paragraphs scores.

Conclusion

When administered at an adequate intensity, variation in the dose and dose frequency of interactive book reading does not appear to influence word learning by children with DLD. Although interactive book reading continues to show promise as an effective word learning intervention for children with DLD, further development is needed to enhance the effectiveness of this treatment approach.

Supplemental Material

https://doi.org/10.23641/asha.9745181
To See or Not to See: How Does Seeing Spellings Support Vocabulary Learning?
Authors: Colenbrander Danielle , Miles Katharine Pace , Ricketts Jessie
Published: October 2019

Purpose

The aim of this study was to determine when, why, and how the presence of a word's written form during instruction aids vocabulary learning (a process known as
orthographic facilitation
).

Method

A systematic review of the research on orthographic facilitation was carried out. PsycInfo, Web of Science, ProQuest, and OpenGrey databases were searched. The search returned 3,529 results, and 23 of these met inclusion criteria. Studies were included in the review if they were written in English, published in a peer-reviewed journal, and compared vocabulary learning outcomes when words were taught with and without their written forms.

Conclusions

There is strong evidence that the presence of a word's written form leads to improved learning of its spelling and spoken form. There is also some evidence that it may lead to better learning of a word's meaning. A small number of studies have also shown that the presence of a word's written form benefits vocabulary learning in children with developmental language disorder, autism, Down syndrome, and reading difficulties. However, further research into the effects of orthographic facilitation in special populations is needed. In particular, ecologically valid experiments in clinical and educational settings are required in order to better understand how exposure to a word's written form can aid naturalistic vocabulary learning.
Parallel resonance type fault current limiting circuit breaker
Authors: Radmanesh Hamid , Fathi Seyed Hamid
Published: October 2019

The main goal of this study is introducing a novel fault current limiter based on parallel resonance structure (PRFCL) for high voltage application. During normal mode, the PRFCL reactor is short‐circuited via a rectifier bridge DC output voltage and LC resonance tank shows negligible impedance in the line. During a fault, the rectifier bridge switches are turned off, so that the parallel resonance LC tank connects to the line with high impedance. This impedance of the resonance structure can limit the fault current, successfully. It is shown that the suggested PRFCL can act as a breaker and opens the line during the fault period. In order to show the suggested PRFCL abilities, MATLAB software is used to simulate the normal and fault cases. In addition, a scale‐down prototype is implemented to confirm the simulation results. The comparative study shows that PRFCL has acceptable performance in normal and current limiting operation modes.
MIMO–OFDM communication systems for traffic data transmission in 5G drone small cells
Authors: Vahidi Vahid , Saberinia Ebrahim
Published: October 2019

A compressed sensing‐based channel estimation (CE) method is proposed for doubly selective channels whilst multiple‐input multiple‐output (MIMO)–orthogonal frequency‐division multiplexing (OFDM) system is employed. According to the simulation results, the proposed CE method, which is dubbed as the MIMO‐linearising scheme performs better than the basic expansion model (BEM), which is a state‐of‐the‐art CE method and applies frequency domain scattered pilots. Furthermore, MIMO‐linearising can be utilised as an accurate procedure for estimating only the positions of non‐zero channel taps in the scenarios where those positions change with a slower rate than amplitudes and phases of the channel taps. Based on that priori estimated positions (PEPs), modified versions of the linearising scheme and the BEM methods, called MIMO‐linearising‐PEP and BEM‐PEP, respectively, are described, showing improvement on performance and spectral efficiency. In addition, by considering the physical characteristic of the vehicular channels, an alternative version of the MIMO‐linearising‐PEP, called MIMO‐linearising‐efficient, is described to reduce the computational complexity and increase the spectral efficiency further. Simulation results indicate that the proposed CE methods can measure the channel more accurately and enhance the car detection accuracy in the frames which have been used as the inputs of the communication systems.
Recursive search‐based identification algorithms for the exponential autoregressive time series model with coloured noise
Authors: Xu Huan , Ding Feng , Yang Erfu
Published: October 2019

This study focuses on the recursive parameter estimation problems for the non‐linear exponential autoregressive model with moving average noise (the ExpARMA model for short). By means of the gradient search, an extended stochastic gradient (ESG) algorithm is derived. Considering the difficulty of determining the step‐size in the ESG algorithm, a numerical approach is proposed to obtain the optimal step‐size. In order to improve the parameter estimation accuracy, the authors employ the multi‐innovation identification theory to develop a multi‐innovation ESG (MI‐ESG) algorithm for the ExpARMA model. Introducing a forgetting factor into the MI‐ESG algorithm, the parameter estimation accuracy can be further improved. With an appropriate innovation length and forgetting factor, the variant of the MI‐ESG algorithm is effective to identify all the unknown parameters of the ExpARMA model. A simulation example is provided to test the proposed algorithms.
Single‐stage high‐frequency‐isolated three‐phase four‐leg buck–boost inverter with unbalanced load
Authors: Gu Ling , Zhu Wei
Published: October 2019

A three‐phase four‐leg inverter shows its preponderance on providing energy to unbalanced load and high DC‐link utilisation. To increase the power density of the traditional three‐phase four‐leg inverter with power frequency isolation, this study proposes a single‐stage isolated three‐phase four‐leg inverter. To ensure the symmetry of three‐phase output voltages, the proposed converter provides the path for neutral current resulted by the unbalanced load. It achieves buck–boost DC/AC conversion by introducing the transformer whose turns ratio provides additional voltage gain. The working frequency of the transformer is in accord with the switching frequency, so high‐frequency electrical isolation is realised with a single‐stage structure as well. The specific mode analysis and the relationship between the switching states and the voltage vectors are presented. A modified three‐dimensional space vector pulse width modulation algorithm with a simplified section partition method is proposed, which guarantees the voltage‐second balance of the transformer within one switching cycle as well. In order to explore the feasibility of the topology and control strategy, the simulation is done by MATLAB/Simulink. Then a prototype was built in the lab and the experimental results verify that the inverter can produce balanced voltages under both balanced and unbalanced load.
Improved TPS control for DAB DC–DC converter to eliminate dual‐side flow back currents
Authors: Luo Suhua , Wu Fengjiang , Wang Guizhong
Published: October 2019

In this study, the essential reason for causing the dual‐side flow back currents in the isolated dual active bridge (DAB) DC–DC converter is originally revealed first. It is because the polarities of the AC side output voltages of the two H‐bridge converters in DAB converter are not able to be always kept the same as that of the inductor current in the conventional modulation strategies. An improved triple‐phase‐shift (ITPS) control is proposed according to the analysis results to ensure that the dual‐side flow back currents are eliminated, and all of the power switches achieve soft switching in the entire power range. The detailed experimental results of the ITPS control validate its validity and feasibility.
Nanosekundenlaserbehandlung bei Chorioretinopathia centralis serosa ohne RPE-Defekte: eine retrospektive Fallserie
Authors: Funk Saskia , Fulga Roxana , Klabe Karsten , Breyer Detlev , Seitz Berthold , Langenbucher Achim , Kaymak Hakan
Published: October 2019

Hintergrund Die Chorioretinopathia centralis serosa (CCS) ist eine ein- oder beidseitige Makulaerkrankung mit einer Abhebung der neurosensorischen Retina. Die Spontanresorptionsrate der subretinalen Flüssigkeit (SRF) bei der akuten CCS liegt bei etwa 68% innerhalb von 4 Monaten und 84% innerhalb von 6 Monaten.

Zielsetzung Ziel dieser Arbeit ist die Untersuchung des Behandlungserfolgs durch die selektive Nanolasertherapie bei CCS-Patienten ohne RPE-Atrophie gegenüber der aktuell empfohlenen konservativen Therapie.

Methode Die retrospektive Auswertung umfasste 23 Augen von 23 Patienten ohne vorherige Therapie bei einer Nachbeobachtungszeit von bis zu 12 Monaten. Die Behandlung erfolgte mit dem 2RT®-Nanolaser Grid-Stimulation der Makula. Ausgewertet wurde die Änderung des bestkorrigierten Visus, der Makulasensitivität aus der Mikroperimetrie und der subretinalen Flüssigkeitshöhe. Alle Zielgrößen wurden 1, 3, 6 und 12 Monate nach der 1. Behandlung aufgenommen. Die Patienten erhielten keine substitutive Therapie.

Ergebnis Zwei Monate nach der 1. Behandlung zeigte sich kumulativ bei 74%, nach 6 Monaten bei 91% der Patienten eine vollständige Resorption der subretinalen Flüssigkeit (SRF). Die zentrale Sehschärfe und die Makulasensitivität verbesserte sich von 0,18 ± 0,16 logMAR zu 0,09 ± 0,17 logMAR und 24,19 ± 3,96 dB zu 27,59 ± 2,89 dB signifikant. Die SRF reduzierte sich innerhalb eines Monats signifikant. Auffälligkeiten in der Angiografie oder Autofluoreszenz blieben aus. Bei keinem Patienten bildete sich im Beobachtungszeitraum eine sekundäre choroidale Neovaskularisation (CNV). Die anfängliche Flüssigkeitshöhe ist ein wesentlicher Faktor für eine schnellere Resorption.

Schlussfolgerung Die Auswertung unserer Behandlungsergebnisse zeigt, dass die Therapie eine sichere und vielversprechende Methode darstellt. Patienten mit einer CCS ohne bestehende RPE-Defekte (RPE: retinales Pigmentepithel) profitieren durch die Behandlung mit dem 2RT®-Nanolaser, damit verbunden ist eine wahrnehmbare Funktionsverbesserung.
Stauungspapille, Pseudotumor cerebri und idiopathische intrakranielle Hypertension – Was gibt es Neues?
Authors: Biermann Julia
Published: October 2019

Die Differenzierung von Stauungspapille, Papillenschwellung und Pseudopapillenschwellung (z. B. kleine, hyperope oder schräge Papillen) bereitet dem Ophthalmologen häufig Schwierigkeiten. Dies führt nicht selten zu Fehldiagnosen, Überdiagnostik und Verzögerungen in der Behandlung. Diese Übersichtsarbeit fasst die neue Literatur zur Stauungspapille im Rahmen des Pseudotumor-cerebri-Syndroms zusammen und vertieft das Verständnis zur Diagnostik und Therapie bei idiopathischer intrakranieller Hypertension (IIH). Dabei wird deutlich, dass sich viele neue Erkenntnisse ergeben haben, wie z. B. der neue Phänotyp des IIH-typischen Kopfschmerzes, der Einsatz der OCT bei der Verlaufsbeurteilung der Stauungspapille und erste Ib-Evidenzstudien zur Therapie mit Acetazolamid. Die Optikusscheidenmeningozele ist eine seltene Differenzialdiagnose in diesem Kontext.
Rhodium(III)-Catalyzed C–H Activation-Based First Total Synthesis of 6-O-Methyl Anciscochine, an Alkaloid Isolated from Ancistrocladus tectorius
Authors: Vargas Didier F. , Romero Brenda S. , Larghi Enrique L. , Kaufman Teodoro S.
Published: October 2019

The concise and efficient first total synthesis of 6-O-methyl anciscochine, employing a tandem C–C/C–N formation approach via a rhodium-catalyzed C–H activation/alkenylation/annulation strategy, is reported. This heterocycle was isolated from the liana Ancystrocladus tectorius and features a unique 3-hydroxymethylisoquinoline core that is found in a few other natural products and in some bioactive synthetic compounds. The synthesis, which was executed in four high-yielding steps and a global yield of 43%, involved the oximation of commercial 2,4-dimethoxyacetophenone under CeCl3·7H2O-promotion, followed by pivaloylation of the oxime. A one-pot pivaloxime-directed alkenyl­ation/annulation stage with methyl acrylate, furthered by a NaBH4/ CaCl2­-mediated reduction of the resulting isoquinoline 3-carboxylate ester completed the sequence.
Radical-Mediated Difunctionalization of Styrenes
Authors: Bao Xiazhen , Li Jun , Jiang Wei , Huo Congde
Published: October 2019

Styrene, an extremely important compound in the chemical industry, is mainly produced by the dehydrogenation or oxidative dehydrogenation of ethylbenzene. Transformation of this raw organic material to more useful fine organic chemicals is a very significant topic. Recently, the radical difunctionalization of styrene has become a powerful and efficient tool for organic synthesis. This strategy can introduce two substituents into a styrene molecule in one step via addition to the C=C bond, enhancing the molecular complexity in a single operation with good selectivity and wide functional group compatibility.

1 Introduction

2 C-Centered Radicals

3 CF3 and Other Polyfluoroalkyl Radicals

4 N-Centered Radicals

5 P-Centered Radicals

6 O-Centered Radicals

7 S-Centered Radicals

8 Other-Atom-Centered Radicals

9 Conclusion and Perspective
Fulminant Necrotizing Enterocolitis and Multiple Organ Dysfunction in a Toddler with Mitochondrial DNA Depletion Syndrome-13
Authors: Nardi Nicolas , Proulx François , Brunel-Guiton Catherine , Oligny Luc L. , Piché Nelson , Mitchell Grant A. , Joyal Jean Sébastien
Published: October 2019

Necrotizing enterocolitis (NEC) is exceptional after the neonatal period. A toddler with encephalopathy, mitochondrial myopathy, and hypertrophic cardiomyopathy developed fatal NEC and multiple organ dysfunction within 48 hours of the introduction of enteral feeding. She was subsequently found to have pathogenic mutations in FBXL4, a cause of mitochondrial DNA depletion syndrome-13. Intestinal dysmotility in the context of deficient mitochondrial respiration may have contributed to the development of NEC. Current paradigms call for early introduction of enteral nutrition to reinstate energy homeostasis. Enteral feeding should be administered with caution during metabolic crises of patients with mitochondrial DNA depletion syndromes.
Investigation of Bosentan's Effects on Pulmonary Contusion Created by Blunt Thoracic Trauma in Rats
Authors: Gercel Gonca , Aksu Burhan , Ozkanli Seyma , Uzun Hafize , Aksu Feyza , Ozatman Erdem , Durakbaşa Çiğdem Ulukaya
Published: October 2019

Introduction Bosentan is an endothelin-1 receptor antagonist with anti-inflammatory, antioxidant, and antiproliferative effects. We aimed to evaluate its effects on lung tissue in a pulmonary contusion (PC) model.

Materials and Methods The rats were randomly divided into five groups: PC3: PC evaluated on the 3rd day (n = 8), PC-B3: PC enteral bosentan 100 mg/kg/day, for 3 days (n = 8), PC7: PC evaluated on the 7th day (n = 7), PC-B7: PC 7 days bosentan 100 mg/kg/day, for 7 days (n = 8), C: control (n = 6). Unilateral lung contusion was created by dropping a metal weight onto the chest. The rats were sacrificed on the 3rd or the 7th days. The lung tissue was evaluated histopathologically for alveolar edema, congestion, and leukocyte infiltration, biochemically for malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) levels, and immunohistochemically for inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), and apoptosis scores.

Results Alveolar edema, congestion, and leukocyte infiltration scores were increased in all groups compared with the control group (p < 0.05) and decreased in bosentan-treated groups compared with the relevant nontreated groups (p < 0.05). Fibrosis was observed only in PC7 and PC-B7 groups. Bosentan did not have any effect on fibrosis development. iNOS and eNOS levels were higher in all groups compared with the control (p < 0.05) without a difference in the nontreated versus treated groups (p > 0.05). Bosentan treatment caused decreased MDA and increased SOD levels in comparison to the nontreated groups (p < 0.05). Tissue NO levels did not show any significant difference among groups. PC groups had higher levels of apoptosis compared with the control group (p < 0.05). The degree of apoptosis decreased in bosentan-treated groups compared with the nontreated groups (p < 0.05).

Conclusion PC causes progressive lung tissue damage. Bosentan reduced leukocyte infiltration and alveolar edema and congestion caused by PC. It also decreased MDA levels and increased SOD levels. Bosentan prevents tissue damage by inhibiting acute inflammatory response and reduces oxidative stress secondary to inflammation. It has therapeutic effects on apoptosis.
Calculating electrostatic interactions in atomic force microscopy with semiconductor samples
Authors: Xu Jie , Li Jinze , Li Wei
Published: October 2019

Electrostatic interactions are important in non-contact atomic force microscopy (AFM) measurement. Previous reports had focused on the calculation of electrostatic interactions in AFM with metal and dielectric samples, and the present work extended the discussion to semiconductor samples based on Green’s function theory and Debye-Hückel theory, considering sample dielectric polarization and free carriers at the same time. In order to enhance the calculation efficiency, an equivalent charge method was implemented and developed with a linear algebra-based algorithm. The calculation results of two limiting cases, metal and dielectric limit with infinite and zero carrier concentrations respectively, were in good agreement with the boundary element method. For a finite carrier concentration, it is found that the electrostatic force on the tip cone is quickly saturated whereas that on the tip apex slowly increases as the carrier concentration increases. On the other hand, the interaction radius on the sample surface is found independent of the sample free carriers, but it linearly increases as the tip-sample distance. Our work can be useful for the carrier concentration detection of semiconductor samples using non-contact electrical AFM modes such as Kelvin probe force microscopy and electrostatic force microscopy.
Non-reciprocal behavior of one-dimensional piezoelectric structures with space-time modulated electrical boundary conditions
Authors: Croënne C. , Vasseur J. O. , Bou Matar O. , Hladky-Hennion A.-C. , Dubus B.
Published: October 2019

Propagation of longitudinal acoustic waves in a one-dimensional piezoelectric structure with space-time modulated electrical boundary conditions is investigated. An analytical model allowing the calculation of eigenmodes for spatially continuous shifts of electrical boundary conditions is compared with finite difference time domain simulation results for a discrete set of time-varying spatially fixed conditions. Both models predict that such a structure behaves as a nonreciprocal device exhibiting unidirectional propagation properties in some frequency ranges. The modulus and direction of the modulation speed vector strongly affect this nonreciprocal behavior. Moreover, other nonlinear phenomena such as frequency up and down conversions, wave packet distortion, and parasitic echoes occurring in such systems are investigated in detail. The importance of these phenomena is discussed in the context of nonlinear acoustic wave-based components for radio-communication systems.
The jet characteristics of bubbles near mixed boundaries
Authors: Li S.-M. , Zhang A.-M. , Wang Q. X. , Zhang S.
Published: October 2019

The jet characteristics of bubbles near mixed boundaries have been the focus of research in many fields. As the associated parameters are complicated, relatively few reports have been published. In this paper, a numerical model is established by considering the influence of the free surface and a mutual vertical wall using the boundary element method. To determine the jet characteristics of collapsing bubbles in different areas, two nondimensional parameters must be investigated: the distance γv from the bubble to the vertical wall and the distance γh from the bubble to the horizontal wall. At the same time, the buoyancy parameter δ cannot be ignored. First, the jet characteristics under an infinite vertical solid wall are discussed; furthermore, the jet direction in the stage of collapsing bubble under combined boundaries without buoyancy is studied, and we find that the variation amplitude of the jet angle changes with the free surface. Considering the buoyancy, we then divide the total area into six regions with different ranges of jet angle under small buoyancy values, allowing the significant effect of buoyancy to be studied as δ increases. In addition, we study the jet velocity qualitatively under the condition of negligible buoyancy and find that a peak jet velocity may exist at mid water depths.
Real-space observation of far- and near-field-induced photolysis of molecular oxygen on an Ag(110) surface by visible light
Authors: Lin Chenfang , Ikeda Kei , Shiota Yoshihito , Yoshizawa Kazunari , Kumagai Takashi
Published: October 2019

Dissociation of molecular oxygen is an important elementary process in heterogeneous catalysis. Here, we report on a real-space observation of oxygen photolysis on the Ag(110) surface at 78 K by far- and near-field excitation in the ultraviolet–near-infrared range using a low-temperature scanning tunneling microscope (STM) combined with wavelength-tunable laser excitation. The photolysis of isolated oxygen molecules on the surface occurs even by visible light with the cross section of ∼10−19 cm2. Time-dependent density functional theory calculations reveal optical absorption of the hybridized O2–Ag(110) complex in the visible and the near-infrared range which is associated with the oxygen photolysis. We suggest that the photolysis mechanism involves a direct charge transfer process. We also demonstrate that the photolysis can be largely enhanced in plasmonic STM junctions, and the cross section is estimated to be ∼10−17 cm−2 in the visible and the near-infrared range, which appears to be an interesting feature of plasmon-induced reactions from the perspective of photochemical conversion with the aid of solar energy.