bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT
Authors: Botter S.M. , van Osch G.J.V.M. , Waarsing J.H. , Day J.S. , Verhaar J.A.N. , Pols H.A.P. , van Leeuwen J.P.T.M. , Weinans H.
Published: November 2024

In the past few years there has been a considerable interest in the role of bone in osteoarthritis. Despite the increasing evidence of the involvement of bone in osteoarthritis, it remains very difficult to attribute the cause or effect of changes in subchondral bone to the process of osteoarthritis. Although osteoarthritis in mice provides a useful model to study changes in the subchondral bone, detailed quantification of these changes is lacking. Therefore, the goal of this study was to quantify subchondral bone changes in a murine osteoarthritis model by use of micro-computed tomography (micro-CT). We induced osteoarthritis-like characteristics in the knee joints of mice using collagenase injections, and after four weeks we calculated various 3D morphometric parameters in the epiphysis of the proximal tibia. The collagenase injections caused cartilage damage, visible in histological sections, particularly on the medial tibial plateau. Micro-CT analysis revealed that the thickness of the subchondral bone plate was decreased both at the lateral and the medial side. The trabecular compartment demonstrated a small but significant reduction in bone volume fraction compared to the contralateral control joints. Trabeculae in the collagenase-injected joints were thinner but their shape remained rod-like. Furthermore, the connectivity between trabeculae was reduced and the trabecular spacing was increased. In conclusion, four weeks after induction of osteoarthritis in the murine knee subtle but significant changes in subchondral bone architecture could be detected and quantified in 3D with micro-CT analysis.
Treatment of human mesenchymal stem cells with pulsed low intensity ultrasound enhances the chondrogenic phenotype in vitro
Authors: Schumann D. , Kujat R. , Zellner J. , Angele M.K. , Nerlich M. , Mayr E. , Angele P.
Published: November 2024

This study examined the effects of low intensity pulsed ultrasound (LIPUS) on human bone marrow-derived mesenchymal stem cells undergoing chondrogenic differentiation. Aggregates of mesenchymal stem cells and mesenchymal stem cells seeded in three dimensional matrices were cultured in a defined chondrogenic medium and subjected to LIPUS for the first 7 days of culture. At 1, 7, 14 and 21 days, samples were harvested for histology, immunohistochemistry, RT-PCR, and quantitative DNA and matrix macromolecule analysis. Cell aggregates with daily treatment for 20 minutes showed no significant differences for proteoglycan and collagen content during chondrogenic differentiation. However ultrasound application for 40 minutes daily resulted in a statistically significant increase of the proteoglycan and collagen content after 21 days in culture. Aggregates treated for 20 minutes daily showed decreased expression of chondrogenic genes at all time points. In contrast, 40 minutes of daily treatment of aggregates resulted in a significant increase of chondrogenic marker genes after an initial decrease at day 7 with time in culture. Ultrasound treated cell-scaffold constructs showed a significant increase of chondrogenic marker gene expression and extracellular matrix deposition. This study indicates that LIPUS can be used to enhance the chondrogenesis of mesenchymal stem cells in cell aggregates and cell-scaffold constructs. We have found a dependency on the specific treatment parameters. We hypothesize that LIPUS can be used for an improved in vitro preparation of optimized tissue engineering implants for cartilage repair. Furthermore this non-invasive method could also be of potential use in vivo for regenerative therapy of cartilage in the future.
Inhibition of interleukin-1β-induced activation of MEK/ERK pathway and DNA binding of NF-κB and AP-1: Potential mechanism for Diacerein effects in osteoarthritis
Authors: Domagala F. , Martin G. , Bogdanowicz P. , Ficheux H. , Pujol J.-P.
Published: November 2024

In the present report we have shown that bovine articular chondrocytes cultured in low oxygen tension, i.e. in conditions mimicking their hypoxic in vivo environment, respond to IL-1β (10 ng/ml) by an increased DNA binding activity of NF-κB and AP-l transcription factors. Incubation of the cells with 10−5 M Rhein, the active metabolite of Diacerhein, for 24 h was found to reduce this activity particularly in the case of AP-1. Mitogen activated kinases (ERK-1 and ERK-2) were activated by exposure of the chondrocytes to a 1 h treatment with IL-1β. This effect was greater in hypoxia (3% O2) than in normoxia (21% O2). Rhein was capable of reducing the IL-1β-stimulated ERK1/ERK2 pathway whatever the tension of oxygen present in the environment. The mRNA steady-state levels of collagen type II (COL2A1) and aggrecan core protein were found to be significantly increased by a 24-h treatment with 10−5 M Rhein. This stimulating effect was also observed in the presence of IL-1β, suggesting that the drug could prevent or reduce the IL-1β-induced inhibition of extra cellular matrix synthesis. IL-1-induced collagenase (MMP1) expression was significantly decreased by Rhein under the same conditions. In conclusion, Rhein can effectively inhibit the IL-1-activated MAPK pathway and the binding of NF-κB and AP-1 transcription factors, two key factors involved in the expression of several pro-inflammatory genes by chondrocytes. In addition, the drug can reduce the procatabolic effect of the cytokine, by reducing the MMP1 synthesis, and enhance the synthesis of matrix components, such as type II collagen and aggrecan. These results may explain the anti-osteoarthritic properties of Rhein and its disease-modifying effects on OA cartilage, in spite of the absence of inhibition at prostaglandin level.
Effects of flow geometry on blood viscoelasticity
Authors: Thurston George B. , Henderson Nancy M.
Published: November 2024

The viscoelastic properties of blood are dominated by microstructures formed by red cells. The microstructures are of several types such as irregular aggregates, rouleaux, and layers of aligned cells. The dynamic deformability of the red cells, aggregation tendency, cell concentration, size of confining vessel and rate of flow are determining factors in the microstructure. Viscoelastic properties, viscosity and elasticity, relate to energy loss and storage in flowing blood while relaxation time and Weissenberg number play a role in assessing the importance of the elasticity relative to the viscosity. These effects are shown herein for flow in a large straight cylindrical tube, a small tube, and a porous medium. These cases approximate the geometries of the arterial system: large vessels, small vessels and vessels with many branches and bifurcations. In each case the viscosity, elasticity, relaxation time and Weissenberg number for normal human blood as well as blood with enhanced cell aggregation tendency and diminished cell deformability are given. In the smaller spaces of the microtubes and porous media, the diminished viscosity shows the possible influence of the Fåhraeus–Lindqvist effect and at high shear rates, the viscoelasticity of blood shows dilatancy. This is true for normal, aggregation enhanced and hardened cells.
Towards a reliable characterisation of the mechanical behaviour of brain tissue: The effects of post-mortem time and sample preparation
Authors: Garo A. , Hrapko M. , van Dommelen J.A.W. , Peters G.W.M.
Published: November 2024

Since the early seventies, the material properties of brain tissue have been studied using a variety of testing techniques. However, data reported in literature show large discrepancies even in the linear viscoelastic regime. In the current study, the effect of the sample preparation procedure and of post-mortem time on the mechanical response of porcine brain tissue is examined. Samples from the thalamus region were prepared with different techniques and were tested for different loading histories. Each sample was tested in oscillatory shear tests (1% strain amplitude, 1–10 Hz frequencies) followed by sequences of 5% strain loading-unloading cycles. The stress response to the loading-unloading cycles showed a clear dependency on post-mortem time, becoming more stiff with increasing time. This dependency was affected by the mechanical history induced by the preparation procedure.
The properties of gelatin–poly (γ-glutamic acid) hydrogels as biological glues
Authors: Hsu Shan-hui , Lin Chen-Huan
Published: November 2024

The influence of the molecular weight and the type of gelatin (A or B), as well as the molecular weight of poly (γ-glutamic acid) (γ-PGA), on the properties of gelatin/γ-PGA mixed bioadhesives were studied. The gelation of the system was enhanced by a crosslinker, 1-(3-dimethylaminopropyl)-3-(ethylcarbodiimide) hydrochloride (EDC). The gelation time of the bioadhesives was analyzed using rheological measurements. The results indicated that the type of gelatin was a critical factor in determining the gelation time of the biological glues. The mixed glues had greater bonding strength and smaller gelation times as the molecular weight of γ-PGA or gelatin increased. The swelling ratio decreased and the denaturation temperature increased upon raising the EDC concentration, indicating a greater degree of crosslinking at higher EDC concentrations. The mixed glues crosslinked with various concentrations of EDC (1.7–2.5%) showed no cytotoxicity to fibroblasts. In addition, no significant inflammatory response was observed in the rat subcutaneous implantation. The bioadhesives based on gelatin/γ-PGA remained at the site for 7 days while the fibrin glue had almost completely degraded. By choosing the appropriate gelatin type and higher molecular weight γ-PGA in the mixtures, the gelatin/γ-PGA biological glues could serve as soft tissue adhesives. Rheological characterization was essential in the evaluation of biological glues.
Staging the Lie: The Impact of Framing and Content on the Visibility of Fake Business News
Authors: Illia Laura , Zyglidopoulos Stelios , Bantimaroudis Philemon
Published: November 2024

What drives the visibility of fake business news? We investigate this timely question by analyzing the framing and content of fake news targeting Fortune 500 companies. Our research reveals that fake business news employing episodic frames—characterized by highly dramatized and unambiguous information—gains more visibility than thematic frames, regardless of an organization’s reputation, its web or media visibility. Additionally, we find that fake news about corporate governance is particularly visible because it presents a detailed narrative about unmet organizational obligations, reducing the ambiguity of the message. In contrast, fake news about corporate social responsibility does not show this effect. These insights enrich existing literature by demonstrating that the visibility of fake news in social media depends not only on emotional dramatization but also on detailed portrayal. In the business context, fake news is an emotionally and cognitively driven phenomenon depending on stylistic and content frames to enhance its visibility.
Binding the Deities: Tibetan Buddhism, Reincarnation and the Chinese Communist Party
Authors: Lama Jigme Yeshe
Published: November 2024

This article investigates the interaction(s) between the communist state of China and Tibetan Buddhism. It will focus on the issue of reincarnation of tulkus or rinpoches, who are hierarchs in the Tibetan Buddhist tradition. This tradition is turning into a major site of contestation between the Tibetans and the party state. When the Peoples Liberation Army (PLA) marched into Tibet, they encountered a unique socio-political system, defined by many as a theocracy. As a belief system, Buddhism has a hegemonic hold over the Tibetans. Moreover, Tibetan Buddhism’s influence is present in the Himalayan belt, a space contested by postcolonial India and China. However, the focus will be on the different modes of interaction between the Tibetan Buddhist elites and the CCP. While the majority of this contact between them is described as a conflict, the article will highlight moments of cooperation and co-option. The process will be understood through the idea of ‘binding the deities’, which was an important mode of the ‘Buddhicisation’ of Tibet and the Himalayas.
Some Peasants’ Good Times under Mao: Privileged Lives in Mao-Era Rural Militias
Authors: Tang Sanjiao
Published: November 2024

This article re-examines a part of peasants’ exclusively privileged experiences of joining militias during the Mao era. The supporting sources come from a variety of informal repositories over eight provinces, such as statistical tables and rosters of rural militias, documents of departments of armed forces, and materials for conferences and classes of militia members. Although these sources are geographically scattered, quantitatively scarce and systematically incomplete, they present significant parts of peasants’ lives involved in Mao Zedong’s mass campaign of mobilisation and militarisation. Based on them, this article explores the political honours, the economic benefits and the enforcement power one enjoyed by joining the rural militias, in addition to the tensions that existed even in the same village centred on pocketing militias’ privileges in the countryside. Exposing these inequalities produced just by owning membership of rural militias challenged the mainstream of existing scholarship depicting Chinese peasants’ lives under Mao as similarly tough and deprived. This exploration also pays attention to the Cold War context that justified and glorified peasants’ good times in the militias, highlighting the Cold War element that contributes to the Mao era nostalgia in today’s China.
Danse Macabre or: How I learned to stop worrying and love death
Authors: Lolli Ghetti Carlo Maria
Published: November 2024

The ‘Danse Macabre’ was a pictorial representation of the mutated attitude towards death generated by the catastrophic plague that decimated the European population during the 14th century. Did the Covid-19 epidemic lead to a similar, nihilistic, visual result?
Factors associated with high nutrition risk by 10-year age group: Data from the Canadian Longitudinal Study on Aging
Authors: Mills Christine Marie , Keller Heather H , Donnelly Catherine
Published: November 2024

Background

Nutrition at midlife and beyond influences how an individual ages. Nutrition risk, the risk of poor nutritional health, is highly prevalent in community-dwelling adults in these age groups. As the factors associated with nutrition risk may vary between different age groups, research is needed on the differences in nutrition risk between age groups.

Aim

To examine the social, demographic, and health factors associated with high nutrition risk, determined using SCREEN-8, using data from the Canadian Longitudinal Study on Aging (CLSA), stratified by 10-year age groups.

Methods

Using the baseline and first follow-up waves of the CLSA, bivariate multivariable logistic regression was conducted to examine the variables associated with high nutrition risk (SCREEN-8 score < 38) by 10-year age group.

Results

Higher levels of social support, higher social standing, more frequent participation in community activities, screening negative for depression, and higher levels of self-rated general health, healthy aging, and oral health were consistently associated with lower odds of being at high nutrition risk across all age groups at both baseline and follow-up.

Conclusion

Individuals with low levels of social support, low social standing, infrequent participation in community activities, poor general health, poor healthy aging, poor oral health, or who screen positive for depression should be screened proactively for nutrition risk. Programs and policies designed to address social support, social standing, participation in community activities, depression, health, healthy aging, and oral health may also help reduce the prevalence of high nutrition risk.
Creatine and sleep habits and disorders in the general population aged 16 years and over: NHANES 2007–2008
Authors: Baltic Sonja , Grasaas Erik , Ostojic Sergej M
Published: November 2024

Background: Preclinical studies have suggested that dietary creatine may affect sleep quality yet no studies have explored the potential association between creatine consumption and sleep patterns or disorders in the general population. Aim: This cross-sectional study aims to examine the association between creatine consumption and sleep habits and disorders among individuals aged 16 years and older, using data from the 2007–2008 National Health and Nutrition Examination Survey (NHANES). Methods: The analysis included 5988 individuals (50.5% females) with a mean age of 47.4 ± 19.5 years. Daily creatine intake was assessed through individual in-person 24-h food recall interviews, categorizing respondents into two groups: those with suboptimal creatine intake (<1.00 g per day) and those meeting recommended intake (dietary creatine ≥ 1.00 g per day). Sleep was evaluated during household interviews using questions on sleep habits and disorders from the NHANES Sleep Disorders component. Results: The average daily creatine intake among participants was 0.88 ± 0.85 g (95% CI, 0.86 to 0.90), while the mean nightly sleep duration was 6.8 ± 1.5 h (95% CI, 6.8 to 6.9). Additionally, 1331 respondents (22.2%) reported consulting a doctor or health professional for sleep-related issues. Participants with suboptimal creatine intake had a significantly higher prevalence of trouble sleeping compared to those consuming recommended amounts (23.7% vs 19.3%; P < 0.01), with an odds ratio of 1.30 (95% CI: 1.13 to 1.48) for experiencing sleep disturbances. However, the prevalence of more severe sleep disorders did not differ significantly between the two creatine sub-populations ( P > 0.05). Conclusion: Our findings suggest that participants meeting recommended creatine intake levels had a reduced risk of experiencing mild sleeping difficulties. These findings may serve as a basis for future interventional studies aimed at validating and confirming the potential benefits of dietary creatine in the field of sleep medicine.
Superelasticity with excellent temperature stability in Cu-Al-Mn shape memory alloy by gradient high temperature rolling
Authors: Liu Jili , Zhang Lei , Lin Yourong , Li Xide , Zhu Yan , Wu Can
Published: November 2024

The objective was to enhance the temperature stability of Cu-Al-Mn shape memory alloys (SMAs) across a wide temperature range. To this end, a gradient rolling treatment at 800 °C (HR) and subsequent heat treatment (HT) were employed to create a gradient texture. The objective was to control and reduce the temperature dependence of superelasticity properties, including superelastic stress ( σM), austenite transformation stress ( σA), damping coefficient ( tanΦ), and so forth, in columnar-grained Cu-Al-Mn SMAs. The results demonstrated that the temperature dependence rate of stress-induced martensitic transformation stress ( σM) initially increased and then decreased with the reduction in gradient range in the RD direction. The dσM/dT value for HRT-65/68 was 0.369 MPa/K. In the TD direction, the dσM/dT of HRT-60V was only 0.232 MPa/K over a wide range of temperatures, approximately 120 K. The excellent superelastic temperature stability observed in this gradient structure Cu-Al-Mn SMA was superior to that of other reported Cu-Al-Mn SMAs and NiTi SMAs. Following gradient rolling treatment, the alloy retained a strong <001>-oriented texture along the RD direction. However, the strength of this texture was reduced, resulting in the formation of non-high phase transition strain orientation and grains with a gradient size distribution. These characteristics contributed to the development of high superelasticity with excellent temperature stability.
Colonial Modernity and the Indian Rebellion of 1857: Unsettling the Nation-State Through Mirza Ghalib’s Dastanbuy
Authors: Chopra Rohan
Published: November 2024

Colonial modernity inscribed hierarchies through regimes of knowledge that reproduced violence by disavowing alternatives. The ‘postcolonial’ nation-state in India is embedded in the logics of majority–minority that perpetuates violence against the citizens of the state who are outside the nation, converting those unable to prove their autochthony into second-class citizens. This article unsettles the permanent majority/minority relations in South Asia through a reading of Dastanbūy by Mirza Ghalib. Ghalib wrote Dastanbuy during the Rebellion of 1857, when the violence of colonial modernity reshaped communitarian relations in Delhi, marking Muslims as ‘outsiders’. This article reads Dastanbuy against this effect of colonial modernity, suggesting that the text unsettles these categories at the time of their making. Accordingly, it recuperates elements from the text to unsettle the naturalised majority-minority relations of the nation-state that colonial modernity births and entrenches. Simultaneously, it uses this as a gateway to engage with non-European concepts and lifeworlds that Ghalib hints towards. Through this, the article historicises Dastanbuy and sees its production as the product of a moment following the Rebellion when religious identities were blurred in the onslaught of extreme colonial violence. In short, the article questions the naturalness of these categories and considers alternate conceptions of non-state-based identitarian relations.
Corporate cybersecurity risk and data breaches: A systematic review of empirical research
Authors: Liu Chelsea , Babar Muhammad Ali
Published: November 2024

Cybersecurity constitutes a major concern for corporations. Given the disciplinary barriers that fragment existing research on cybersecurity, we conduct a systemic review of 203 empirical studies on the determinants and consequences of corporate cybersecurity risk across 12 disciplines. By consolidating multidisciplinary research, we develop a novel framework mapping the inter-relationships between the drivers of cybersecurity risk, impacts of cyberattacks, and potential feedback mechanisms enabling firms to learn from breaches to improve cybersecurity outcomes. We provide a taxonomy of both cybersecurity risk factors and impacts of cybersecurity breaches. Our study provides valuable insights to executives, investors, and regulators by enhancing risk awareness and enabling industry practitioners and policymakers to harness the power of academic research to strengthen corporate cybersecurity resilience.

JEL Classification: G30, G32, D81, D62, J24.
Robust Lane Line Detection and Tracking Using Enhanced DBSCAN Optimized RANSAC and Optical Flow
Authors: Guo Yu , Nie Guigen , Gao WenLiang , Liao Mi
Published: November 2024

To deal with real-world complexities, such as varying road conditions, noise interference, and lane line occlusions, we present a highly efficient and robust algorithm for detecting and tracking lane lines using camera sensors. By leveraging the accessibility and affordability of camera sensors over other sensing technologies like Light Detection and Ranging (LiDAR), our approach provides a cost-effective solution for applications. We refine the density-based spatial clustering of applications with noise through a fusion strategy for clustering to address the crucial challenges of noise interference and detection accuracy in this domain. This strategy, which relies on angle and centroid calculations, significantly mitigates noise interference and bolsters the detection accuracy of solid and dashed lane lines. Such enhancement promotes comprehensive lane line detection and reinforces its stability under diverse road conditions. We also restructure the inlier selection logic of random sample consensus to enrich the model selection mechanism and strengthen the anti-noise mechanism. Such improvements increase the algorithm’s robustness and adaptability. To augment the tracking capability of our algorithm, we integrated the Kalman filter and optical flow computation. The incorporation of tracking logic rooted in lane line features and movement direction during optical flow computation efficiently resolves detection issues during lane line occlusion. Our method processes a single frame image on the datasets within only 0.1045 s, reducing overall runtime by roughly 82.4% compared with conventional algorithms.
Overview of the use of recycled plastic in concrete mixtures: Research and patents
Authors: Beltrán Armenta José Luis , Sánchez-Atondo Alejandro , Salazar-Briones Carlos , Mungaray-Moctezuma Alejandro , Gutierrez-Moreno José Manuel
Published: November 2024

Environmental studies have been concerned about the growth of plastic pollution in different ecosystems during the last decades, trying to raise awareness of the current and near-long-term situation. That is why different researchers have proposed the reuse of solid plastic waste, reincorporating it as a material within the construction area, using it as an “aggregate” in concrete mixtures for different types of uses that it provides, being one of the materials most used in the construction industry. The work presents the differences in how to reuse different types of recycled plastics as material/aggregate in concrete production, the experiments to which different samples were subjected, and their results. This paper is divided into five sections. The first section consists of a brief presentation of the types of plastics, their uses, and how they have been used in experiments in different laboratory tests. The following two sections address the properties provided by the use of recycled plastic in concrete mixtures in both fresh and hardened states. The fourth section focuses on the existing approaches in patents within the same topic, which are annexed. Then, we move on to the fifth section, discussing the contradictions and implications of producing concrete with recycled plastic.
The Gaze of the Gatekeeper: Frontline Social Workers’ Perceptions of sex Workers When Making Recommendations About Treatment
Authors: Lown Josh , Chiavelli Samantha , Collier K. Megan
Published: November 2024

Healthcare settings are often one of the primary touch points for sex workers connecting with social services. This places social workers in hospital settings in an important role, using their clinical and social work training and education to make case recommendations based on the immediate needs of sex workers in their care. This qualitative study uses interviews to examine the decision-making processes of social workers in a hospital setting when making case recommendations for sex workers, as well as their attitudes towards sex work as a profession. Findings reveal how social workers, through their navigation of complex institutional networks, often employ decision-making tactics that reflect carceral social work logics and gatekeeping. We also find how other important factors, such as a social workers own professional experience, play an important role in these decision-making processes. We conclude by discussing how social work practitioners can critically interrogate their role within oppressive and carceral state structures to promote an anticarceral social work field that reflects the needs of sex workers in their care.
Health and University Students: The Mediator Role of Emotion Regulation Between Academic Stressors and Health Behaviors
Authors: Cassaretto Mónica , Vilela Patty , Dávila Miguel , Calderón Arturo
Published: November 2024

Purpose

To determine the role of Health Behaviors and Cognitive Emotion Regulation Strategies in the relationship between Health and Academic Stress.

Design

A cross-sectional study with in-person administration of questionnaires.

Setting

Data collection took place at nine public and private universities in Peru, involving a diverse group of students from different faculties.

Sample

1640 students, a majority of them female (61.8%), ranging in age between 18 and 30 years old ( M = 20.72; SD = 2.22).

Measures

A sociodemographic form was used to collect participants’ sociodemographic, academic, and health data. Academic stress was measured by the Inventory of Academic Stress (SISCO). Health habits were assessed using the University Students Lifestyle Questionnaire (CEVJU-Perú). The Cognitive Emotion Regulation Questionnaire (CER-Q) and the SF-36 Questionnaire were also used to evaluate cognitive emotion regulation strategies and health-related quality of life, respectively.

Results

The SEM model results ( x 2 /df = 2.30, CFI = .95, RMSEA = .03, SRMR = .04) reveal that Academic Stress has direct and indirect effects on Health. Negative Emotional Regulation have a negative impact on Health, this effect is direct; while Positive Emotional Regulation has an effect on Health, this effect is direct and indirect, the latter is through Sleep Management, Physical Activity and Leisure Management. In addition, Academic Stress maintains a direct effect on only one health behavior, Sleep Management.

Conclusions

This study’s findings contribute to a better understanding of the role played by emotion regulation, and by positive strategies in particular, in student health.
Work–Family Conflict and Proactive Career Behaviors: The Roles of Career Resilience and Conscientiousness
Authors: Rao Lan , Xu Jia , Zhou Miaodi
Published: November 2024

Proactive career behaviors are critical for employee development, especially in today’s uncertain environment. This study explores the impact of work–family conflict on proactive career behaviors, focusing on the mediating role of career resilience and the moderating role of conscientiousness, grounded in the conservation of resources theory. Using two-wave data from 169 employees in China, the results show that work–family conflict leads to a decrease in proactive career behaviors, with career resilience serving as a mediator. Additionally, conscientiousness intensifies the negative effects of work–family conflict on proactive career behaviors. This research provides an initial investigation into the link between work–family conflict and proactive career behaviors, offering practical implications for human resource management and career counseling.
Effect of pouring temperature and rate of glass on thermal shock behavior of nuclear waste container
Authors: Li Tianning , Yang Xinyi , Huang Bensheng , Gan Yi , Zhu Yongyou , Zheng Jianneng
Published: November 2024

In this paper, the injection process of glassy nuclear waste is simulated using the ANSYS Workbench simulation platform and the birth and death element method. The results show that the temperature change trend obtained by simulating the injection process of solidification container by using the birth and death element method is consistent with the literature results. It is feasible to simulate the injection process of glassy nuclear waste by using the birth and death element method of ANSYS. The thermal calculation results show that the container above the liquid level will produce large stress due to mutual restraint, and the container will undergo plastic deformation when heated during the injection process. As the pouring temperature increases from 1000°C to 1200°C, the maximum stress at the upper head increases from 212.88 to 232.46 MPa. The deformation degree of the solidified container increases with the increase of pouring temperature during the injection process. With the increase of pouring rate from 0.025 to 0.04 kg/s, at the end of injection, the maximum stress of the upper head decreases from 226.96 to 214.71 MPa with the increase of pouring rate. The overall deformation degree of the solidified container increases with the increase of the pouring rate.
The Affect Misattribution Procedure Revisited: An Informational Account
Authors: Pillaud Nicolas , Ric François
Published: November 2024

The aim of this research was to test an informational explanation of the effects observed in the affect misattribution procedure (AMP). According to this explanation, participants performing the AMP would simplify the task by asking whether the target is pleasant (yes vs. no) and would use the affective information provided by the prime to answer the question (positive = yes, negative = no). In line with this proposition, we observed in three preregistered experiments that slightly modifying the response options proposed in the task moderated the effect, which can be canceled (Experiment 1) and even reversed (Experiments 2 and 3). These results are consistent with the informational explanation and seem difficult to explain by the operation of misattribution processes.
Advanced day-ahead scheduling and management of renewable energy systems integration with hydrogen storage in the power grid
Authors: Enobong Sunday Samuel , Abdalla Ahmed N , Latifi Mohsen , Suzuki Kengo
Published: November 2024

The current state of the power system is significantly influenced by various factors, including price fluctuations, which have an uncertain impact on efficiency. Therefore, employing uncertainty modeling is crucial. This study investigates the application of the Improved Manta Ray Foraging Optimization strategy for intelligently managing electric vehicle parking spots, taking into account the uncertainties associated with changes in primary power grid pricing throughout the demand response program (DRP). By alternating between peak and light-load periods, the proposed strategy effectively reduces daily costs. Key components of the proposed scheme include a non-dominated arrangement model, variable discovery, a memory-based method for selection, and fuzzy logic to identify the optimal Pareto front. The suggested method demonstrates a rapid response time in reaching final solutions and exhibits a high potential for achieving global optima. However, Hydrogen Storage Systems present several significant constraints that must be considered during modeling. The most critical limitations involve the electrolyzer's capacities, the fuel cell boundaries, and the storage tank's capacity. The efficacy of the proposed algorithm is validated within a system that incorporates parking and multiple uncertain resources. Results confirm the exceptional ability of the proposed method to manage uncertainty effectively. Consequently, the cost fluctuations of the system power load have been reduced by up to 41%. Additionally, when DRP is included, the average SPL cost increases by 4.92%, while the variation in SPL expenses decreases by 47.01%.
Wogonin Alleviates Aconitine-induced Gastric Tissue Damage in Gastric Cancer through PI3K/Akt Signaling Pathway
Authors: Guo Cunguo , Fu Yiyue , Tang Xiaodong , Hu Yichen , Zheng Shufeng
Published: November 2024

Background and Purpose

Aconitine is a toxic substance capable of causing damage to the nervous system, digestive system, and gastric tissue. Wogonin exhibits significant antibacterial, antioxidant, and potential anticancer effects. The PI3K/Akt pathway is known to engage in the development of cancer cells. Consequently, it is of great significance to investigate the potential of wogonin on aconitine-induced gastric tissue damage in gastric cancer (GC) and its correlation with the signaling pathway.

Methods

Forty modelled mice were divided into a normal group, normal saline group, aconitine (low, high) dose group, wogonin (high, medium, low) dose group, celecoxib group, and Weifuchun group. After treatment, we detected the mouse’s tumor volume and survival day, as well as determined the expression of PI3K/Akt, LC3B, and p62.

Results

During modeling, HE staining revealed that the low-dose aconitine group exhibited improved pathological conditions, reduced tumor volume and mass compared to the saline group, and elevated survival days. After modeling, tumor volume and mass decreased concentration-dependent in each wogonin dose group. Wogonin treatment greatly prolongs survival days and effectively inhibits tumor growth. The expressions of LC3B, P62, PI3K, Akt, and mTOR mRNA were all decreased compared to the model group. Meanwhile, the treatment promoted the expression of LC3 and Beclin1 proteins related to the autophagy pathway.

Conclusion

Wogonin effectively ameliorates gastric tissue damage induced by aconitine in GC, prolongs the survival days of mice, and inhibits tumor growth through activation of the PI3K/Akt signaling pathway and reduction of P62 protein.
Building Future-focused Skills from International Mobility Experience: Perspectives of Vietnamese Academics
Authors: Vo Phuong Quyen , Fischetti John
Published: November 2024

Future-focused skills (FFSs) is an umbrella term identified by multiple international organizations to describe the kinds of attributes that individuals need to be successful in the interconnected world of the 2020s and beyond. International mobility experience has been supported in the literature to enhance participants’ knowledge, skills, and dispositions beyond the domains of their degrees. However, limited empirical research has explored the development of FFSs in mobility schemes for early or mid-career professionals studying postgraduate degrees around the world, especially in Western contexts. Built on a PhD study, this article reports the perspectives of Vietnamese academics of FFSs and their growth in FFSs from participating in mobility experiences in over 10 English-speaking countries. A thematic analysis of 132 survey respondents and 20 in-depth interviews revealed their beliefs, engagement, and influential factors for their FFSs development. This provides important implications for participants and stakeholders of international mobility programs worldwide.
Social Support Congruence Among Team Members: A Cubic Response Surface Analysis
Authors: Berg Ann-Kathleen , Schulte-Seitz Eva-Maria , Kauffeld Simone
Published: November 2024

This study investigates provided and received social support among team members on meeting-related outcomes based on their person–group fit perspective. It further examines whether this support-based need–supply fit, as indicated by support congruence, relates to their verbal behaviors. Results of cubic polynomial regressions across 303 participants nested in 53 teams reveal that social support congruence predicts team members’ meeting citizenship behavior. Moreover, perceived support congruence functions as a mediator of the relationship between relations-oriented verbal behaviors and meeting citizenship behavior. Theoretical and practical implications for the role of support congruence and verbal behaviors during team meetings are discussed.
The integration of virtual patients into nursing education
Authors: Padilha José Miguel , Costa Patrício , Sousa Paulino , Ferreira Ana
Published: November 2024

Background

The use of virtual patients in nursing education has emerged as a valuable tool for developing clinical decision-making skills. However, little is known about the outcomes of incorporating virtual patients into nursing education curricula. The Nursing School of Porto has dedicated efforts to developing clinical scenarios and integrating virtual patient simulation into its nursing degree curriculum. This study aims to evaluate the outcomes of integrating virtual patient simulation into the nursing degree curriculum, specifically focusing on physical nursing examination, nursing diagnosis, nursing treatment, and overall nursing decision-making scores.

Method

An observational, retrospective, and descriptive study was conducted using a non-probabilistic convenience sample of 521 second-year nursing degree students.

The results

On average, students completed 31 virtual patient simulation training sessions. Students obtained an overall score of 82.5% (SD=8.52) for nursing decision-making, a physical examination score of 85.6%, a diagnostic activity score of 72.1%, and a implemented treatment score of 82.8%. Positive relationships were observed between the number of completed scenarios, the overall average evaluation score, and final marks.

Conclusion

The integration of virtual patients yielded a positive impact on nursing education. However, further evidence is necessary to determine the impact of virtual patient simulation on the clinical competencies of nursing degree students.
Outcomes of Palatal Fistula Closure with Tongue Flap Using a Parachute Technique
Authors: Khalili Neda , Hassanpour Seyed Esmail , Rouientan Abdolreza
Published: November 2024

Objective

To evaluate the efficacy of tongue flaps in closing large palatal fistulas secondary to cleft palate repair in terms of functionality, esthetics, and donor site morbidity.

Design

Tertiary academic center.

Setting

We report our 8-year surgical experience with tongue flaps, with our parachute suture technique in flap inset, and not using tongue fixation methods or feeding tubes.

Participants

Nineteen patients having recurrent secondary palatal fistula, post-cleft treatment were treated with anteriorly based dorsal tongue flaps.

Main outcome measure

Patients were evaluated for outcome in terms of flap uptake and effectiveness, correction of oronasal regurgitation, speech and nasality improvement, donor site morbidity, and esthetics.

Results

A total of 19 patients in the age range of 1.5 to 34 years were treated with anteriorly based tongue flap. Detachment of the tongue flap was observed in 1 patient. Furthermore, tongue flap necrosis was not observed in any of the patients. Nasal regurgitation was resolved completely in 15 cases (78.9%), and 2 out of 4 failed cases were due to fistula presence in a position out of flap territory. In addition, fistula persists in the case of flap detachment and another case at the location of pedicle division. Speech intelligibility and hypernasality changes were reported as noticeable improvement in 9 (47.4%) and no obvious change in 10 patients (52.6%).

Conclusion

Using parachute suturing technique can facilitate successful lingual tissue inset in palatal defects with negligible remnant fistula. Moreover, avoiding tongue fixation methods and nasogastric tube-assisted feeding wasn’t associated with increased flap dehiscence or suture loosening.
A Commentary on Miron et al. (2024): The Essentialist Gender Assumptions and the Overgeneralization of Managerial Power’s Impact on Perceptions of Organizational Justice
Authors: Ji HongMei , Shen Jie
Published: November 2024

The commentary critiques Miron et al.’s (2024) study on managerial power and gender inequality for its oversimplification of organizational justice through binary gender and power distinctions. It takes issue with the study’s assertion that female managers are inherently more sensitive to gender issues, which could reinforce stereotypes and overlook individual and contextual differences. The study also overgeneralizes the negative impact of power on justice perceptions, failing to recognize that power can both hinder and promote fairness. The commentary advocates for a more nuanced understanding and calls for diverse, longitudinal research to better capture these dynamics.
Recognizing the Past to Facilitate Healing in the Future: The ALLOW Model
Authors: Mete Rosina E.
Published: November 2024

It is estimated that the United States has one of the highest rates of adoption worldwide which continues to grow. However, much of the available research focuses on children and adolescent adoptees. Clinical studies show that adult adoptees have a higher probability of experiencing mental health concerns and have trouble with stress management. Given their developmental stage, an empowering evidence-based strategy may assist with their life journey and promote self-development and acceptance. The following article outlines a therapeutic technique using the acronym ALLOW. ALLOW stands for Acknowledge, Listen, Learn, Observe, and Write. The author introduces the acronym along with clear instructions on how to implement and problem-solve any challenges. Additionally, ideas for evaluation and studies are discussed.
Two Years Post-COVID-19: An Ecologic Study Evaluating the Impact on Brazil’s Mammographic Screening Program
Authors: Antonini Marcelo , Mattar André , Pinheiro Denise Joffily Pereira da Costa , Teixeira Marina Diógenes , Amorim Andressa Gonçalves , Ferraro Odair , Cavalcante Francisco Pimentel , Zerwes Felipe , Madeira Marcelo , Millen Eduardo de Camargo , Frasson Antônio Luiz , Lopes Reginaldo Guedes Coelho , Brenelli Fabrício Palermo , Leite Renata Montarroyos , Gebrim Luiz Henrique , Freitas-Junior Ruffo
Published: November 2024

Objectives

The objective of this study was to assess the impact of the COVID-19 pandemic, after 2 years, on mammographic screening in Brazil evaluating BIRADS® results, breast cancer diagnosis rates, and breast cancer stage.

Study Design

This was an ecological observational study based on retrospective data from Brazil’s mammographic screening program from 2015 to 2023.

Methods

Data were obtained from the national screening database DATASUS – SISCAN (Cancer System Information) and retrieved in March 2024. Inclusion criteria comprised completeness of mammogram data (incomplete records were excluded), female participants aged 50 to 69 years, and mammograms exclusively performed for screening purposes. The study analyzed the number of mammograms conducted during the specified period, focusing on BIRADS® test results.

Results

Out of 23,851,371 mammograms performed between 2015 and 2023, 15,000,628 were included for analysis. A significant reduction of 39.6% in mammograms was observed in 2020 compared to 2019, followed by a 12.6% decrease in 2021. Notably, a substantial rise in BIRADS categories 4 and 5 examinations was seen post-pandemic. Breast cancer staging analysis revealed a shift towards more advanced stages (III and IV) diagnosed post-pandemic, suggesting potential delays in detection and diagnosis.

Conclusions

In conclusion, the study highlighted significant discrepancies in mammographic screenings and breast cancer diagnosis rates over 9 years. The pandemic reflected significant influence on the timing and stage at diagnosis, suggesting potential delays in detection and diagnosis that resulted in later identification of more advanced disease stages.
Efficacy and safety of daratumumab for the treatment of refractory/relapsed multiple myeloma. A systematic review of meta-analyses
Authors: Moustafa Diala Alhaj , Shafei Laila , Sulaiman Ruba , Yassin Mohamed A , Abushanab Dina , Algarabli Yousef , Al-Badriyeh Daoud
Published: November 2024

Introduction

Several meta-analyses (MAs) of the efficacy and safety of daratumumab in refractory/relapsed multiple myeloma (RRMM) exist. They include different types of populations, Daratumumab regimens, and outcomes. Moreover, there is a wide variation in methodological quality and risk of bias.

Objective

This study aimed to conduct a systematic review of MAs to summarize the literature on the efficacy and safety profile of daratumumab use in RRMM, and also provide an assessment of the quality and risk of bias of the MAs if sufficient data is available.

Methods

The literature databases Pubmed, Embase, Web of Science, and Cochrane were searched since inception. The quality of methodology was assessed by the AMSTAR-2 tool, and the risk of bias was assessed by the ROBIS tool.

Results

Eight MAs were included in the SR. Most studies reported ORR and CR improvement by adding daratumumab to the chemotherapy regimen. Five MAs reported improvement in PFS in daratumumab-based regimens compared to non- daratumumab-based regimens. Only two MAs reported molecular response, favoring daratumumab. Dara was associated with adverse drug events (ADEs), including pneumonia and diarrhea. Conflicting evidence regarding hematological ADEs association with daratumumab exists. The overall quality of the studies is poor, but the MAs had a low risk of bias overall.

Conclusion

Despite including low-quality MAs, this SR provides a summary that simplifies clinicians’ access to efficacy and safety outcomes of daratumumab in RRMM patients. Future studies are required to reduce the uncertainty and produce higher-quality Mas, particularly regarding daratumumab's safety.