bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthetic Protocols, Structural Activity Relationship, and Biological Activity of Piperazine and its Derivatives
Authors: Faizan Md , Kumar Rajnish , Mazumder Avijit , Salahuddin  , Kukreti Neelima , Kumar Arvind , Chaitanya M.V.N.L.
Published: April 2024

:

The versatile basic structure of piperazine allows for the development and production of
newer bioactive molecules that can be used to treat a wide range of diseases. Piperazine derivatives
are unique and can easily be modified for the desired pharmacological activity. The two opposing
nitrogen atoms in a six-membered piperazine ring offer a large polar surface area, relative structural
rigidity, and more acceptors and donors of hydrogen bonds. These properties frequently result in
greater water solubility, oral bioavailability, and ADME characteristics, as well as improved target
affinity and specificity. Various synthetic protocols have been reported for piperazine and its derivatives.
In this review, we focused on recently published synthetic protocols for the synthesis of the
piperazine and its derivatives. The structure-activity relationship concerning different biological
activities of various piperazine-containing drugs was also highlighted to provide a good understanding
to researchers for future research on piperazines.
Cerium Oxide Nanoparticles Synthesis using Alhagi Maurorum Leaf Extract and
Evaluation of Their Cytotoxic Effect on Breast Cancer Cell Lines and Antibacterial
Effects
Authors: Hosseini Sayedeh Azimeh , Khatami Mehrdad , Asadollahi Amirkian , Yaghoobi Hajar
Published: April 2024

Introduction:

Green synthesis offers a fast, simple, and economical method for producing metallic
nanoparticles.The basis of this method is to obtain nanoparticles using natural materials, such as plants, fungi, and
bacteria, instead of harmful and expensive chemical-reducing agents. In this study, CeO2NPs were produced
using Alhagi maurorum extract, and their anticancer and antibacterial activities were evaluated.

Methods:

Alhagi maurorum extract was prepared according to a previously described protocol, and CeO2NPs
were synthesized from the salt of this extract. The resulting nanoparticles were characterized using Transmission
electron microscopy (TEM), scanning electron microscope (SEM), and X-ray diffraction (XRD) techniques. The
antibacterial and cytotoxic effects of the nanoparticles were measured by MIC, MBC, and MTT assays, respectively.
The results were analyzed using one-way analysis of variance (ANOVA) using Prism software.

Results:

The MTT assay on breast cancer cell lines showed that the cytotoxic effect of CeO2NPs on cell lines was
concentration-dependent. In addition, this nanoparticle was more effective against Gram-positive bacteria.

Conclusion:

These nanoparticles can be used as cancer drug delivery systems with specific targeting at low concentrations
in addition to anticancer treatments. It can also have biological and medicinal applications, such as
natural food preservation and wound dressing.
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS).
A Narrative Review
Authors: Farah Stephanie , Nasr Leah , Eid Fares Jocelyne
Published: April 2024

Background:

A far more common disease than Cushing’s syndrome is subclinical
hypercortisolism or mild autonomous cortisol secretion (MACS), with an overall prevalence of
0.2-2%.

Objective:

This review aims to shed light on the prevalence, screening and diagnostic criteria,
comorbidities, and management of Mild Autonomous Cortisol Secretion (MACS).

Methods:

Studies eligible targeted MACS regarding prevalence, screening, comorbidities, management,
and clinical outcome. This is a narrative-review. IRB approval was not needed.

Results:

The 1 mg Dexamethasone suppression test (DST) remains the first screening test.
MACS is associated with adverse cardiometabolic and renal outcomes, osteoporosis and osteopenia,
immunodeficiency, depression, coagulopathy, and sarcopenia. Surgery is the gold standard
treatment. Medical therapy is recommended when surgery is contraindicated or not feasible.
Clinically silent hypercortisolism is a frequent entity that necessitates early detection and treatment.
The production of cortisol should be looked at as a spectrum where subtle, undetectable
levels can still be produced. They know its association with adverse health outcomes.

Conclusion:

MACS is no longer considered an asymptomatic disorder; repeated hormonal and
functional tests are crucial to prevent multiorgan damage.
Nano-Based Theranostics Approach in the Management of Cancer:
Review
Authors: Singh Sonia , Chauhan Vandana , Barik Piyali
Published: April 2024

Cancer is a prevalent and potentially fatal disease worldwide. The proliferation of abnormal
cells and uncontrolled cellular growth characterizes cancer. Cancerous tumors exhibit distinct
microenvironments characterized by a deficient lymphatic drainage system and aberrant blood supply.
Various medications and diagnostic systems exist for cancer treatment, but they all have inherent
limitations and undesirable consequences. Consequently, the achievement of effective cancer detection
and treatment remains challenging. Theranostics nanoparticles are becoming increasingly
popular in nano drug delivery systems. These nanoparticles can diagnose and treat tumors, making
them a promising approach in the field. They are designed to be small in size, allowing them to be
effective in delivering drugs to targeted areas. Furthermore, these nanoparticles can fundamentally
transform the identification and management of several ailments, including cardiovascular disorders
and infectious diseases. Such nanoparticles possess dual capabilities, functioning as therapeutic
agents and diagnostic tools. They can transport medicinal substances, such as medications, nucleic
acids, or therapeutic proteins, and include substances that can be used for imaging, such as contrast
agents or fluorescent dyes, to enable non-invasive diagnostics and monitoring of the effectiveness of
the treatment. These techniques can be employed for diagnostic purposes to identify, locate, and determine
the extent of disorders using imaging modalities such as magnetic resonance imaging, computed
tomography, positron emission tomography, and fluorescence imaging. These nanoparticles
can deliver therapeutic compounds to specific locations accurately during therapy. This leads to improved
effectiveness of the treatment, decreased adverse effects, and better patient outcomes. They
offer a potential nanomedicine approach by providing diagnostic and therapeutic capabilities for disease
diagnosis and treatment. Theranostics nanoparticles have distinct characteristics and adaptability,
which can transform the healthcare sector by facilitating personalized and precise medical treatments.
Lipid-based Drug Delivery Systems: A Promising Approach for Overcoming Bioavailability and Solubility Challenges in Drug Development
Authors: Gupta Akash , Mittal Vishnu , Sharma Anjali , Barak Aashima , Arora Deepshi
Published: April 2024

:

For an extended period, lipid-based drugs have been employed to enhance the effectiveness
of medications. Nevertheless, the notion of using lipids as carriers for drugs remains a fascinating
concept. Lipid-based drug delivery systems (LBDDS) represent a cutting-edge technology
aimed at tackling the challenges associated with bioavailability and solubility of drugs that are not
readily soluble in water.

:

The primary objective of lipid-based medicine formulation is to increase its bioavailability. The
use of lipids in medicine administration is a feasible concept even if it is no longer new. LBDDS
is one of the newest techniques for resolving problems with low water-soluble medication solubility
and bioavailability. Pharmaceuticals may be marketed successfully formulated using these formulations
for parenteral, pulmonary, topical, or oral administration.

:

This article functions as a comprehensive review of existing literature on LBDDS. It involves a
thorough investigation across various databases, including PubMed, Scopus, and Web of Science,
with the aim of identifying relevant research studies.

:

LBDDS are an effective method for making poorly soluble medications (BCS Classes II & IV)
more soluble and more bioavailable. This review article aims to draw attention to the importance
of distinguishing between SMEDDS and SNEDDS, as well as the roles played by the many components
that are needed for creating LBDDS. It also provides motivation and guts to expand the
use of LBDDS on a pilot and industrial scale.

:

Medication delivery systems based on lipids provide a wide range of possible applications by improving
the bioavailability of some poorly soluble medicines and enabling the creation of physiologically
well-tolerated medication formulations. Comprehending the physicochemical properties
of molecules, fatty excipients, and gastrointestinal digestion is crucial for the creation of these systems.
In conclusion, these delivery methods seem to have a bright future.
Pro-Environmental Behaviors in Higher Education: A Contextualized
Planned Behavior Perspective
Authors: Kitheka Bernard M.
Published: April 2024

Background::

Institutions of higher learning are critical avenues for addressing issues
pertaining to climate stability and environmental sustainability. College students, as future leaders,
can play a crucial role in solving the planet’s most pressing problems if they have the right
information and a behavioral orientation that promotes positive environmental outcomes

Objectives::

The current study evaluates pro-environmental behaviors potentially moderated by
knowledge, attitudes, motivations, and contextual factors for college students. It also evaluates
what categories of environmentally friendly behaviors students elect to engage in.

Methods::

Quantitative data were collected using an online questionnaire survey. Data were analyzed
using SPSS statistical software.

Results::

Findings show a weaker influence by most stand-alone factors but a stronger cumulative
effect when all the variables are considered together. Data also indicates student’s inclinations to
certain environment-friendly behaviors more than others.

Conclusion::

Study findings could be used to change university sustainability policies and curricula
to enhance environmental consciousness and inspire participation in green initiatives among
students. The study contributes to existing literature on sustainability in higher education institutions
in the United States.
The Relationship between Job Satisfaction and Burnout in Healthcare Professionals: Meta-Analysis
Authors: Mutlu Hatice , Aydin Okan Anil
Published: April 2024

Aim: The study aims to gather under a single roof a meta-analysis of the relationship between job satisfaction and burnout in healthcare workers, carried out in OECD countries, and to obtain a general result. Method: Unlike similar methodologies employed in assessing the correlation between job satisfaction and job performance in international literature, the study employed the meta-analysis technique in its methodology. For this aim, the literature was systematically reviewed, and 35 specific studies meeting the established criteria were included. The initial step involved uploading these studies into the Comprehensive Meta-Analysis V3 program and subsequently coding them for analysis. Before commencing the study analysis, the decision was made regarding the model for the effect size calculation, with preference given to the random effects model. Following this, the analysis encompassed effect size determination, examination of publication bias, and execution of subgroup analyses. Results: Considering the prominent findings of the study, a negative and significant relationship was found between job satisfaction and burnout. The individual studies included in the study do not have publication bias. There exists a statistically significant difference among countries concerning the correlation between job satisfaction and burnout. Conclusion: The structure and functioning of countries' health systems are unique and different. The effects of this situation are also reflected in the findings of the study. To increase the satisfaction of healthcare professionals, human resources strategies specific to the dynamics of each country should be determined and implemented, and the results should be monitored.
Los empresarios como actores de la gobernanza internacional en el contexto de la integración
Authors: López-Niño Desiderio , López-Bolaños Edmé Alejandra
Published: April 2024

La integración, como mecanismo que trasciende el aumento de los volúmenes de comercio, requiere la construcción ingeniosa y creativa de normas e instituciones transnacionales. Este artículo plantea la tesis de que las instituciones no formales —cultura, creencias y costumbres—, construidas por los empresarios nacionales, son fundamentales para diseñar una gobernanza internacional en el contexto de la integración. Al entrevistarlos, estos actores manifiestan que experimentan restricciones a la hora de participar en forma activa en la sociedad transnacional, que surgen de la internacionalización de los mercados y de los procesos de transformación institucional inherentes. Se sugiere, por lo tanto, construir una gobernanza regional, mediante formación de consensos y creación de metas colectivas.
ChatGPT and Google Assistant as a Source of Patient Education for Patients With Amblyopia: Content Analysis
Authors: Wu Gloria , Lee David A , Zhao Weichen , Wong Adrial , Jhangiani Rohan , Kurniawan Sri
Published: April 2024

Background

We queried ChatGPT (OpenAI) and Google Assistant about amblyopia and compared their answers with the keywords found on the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) website, specifically the section on amblyopia. Out of the 26 keywords chosen from the website, ChatGPT included 11 (42%) in its responses, while Google included 8 (31%).

Objective

Our study investigated the adherence of ChatGPT-3.5 and Google Assistant to the guidelines of the AAPOS for patient education on amblyopia.

Methods

ChatGPT-3.5 was used. The four questions taken from the AAPOS website, specifically its glossary section for amblyopia, are as follows: (1) What is amblyopia? (2) What causes amblyopia? (3) How is amblyopia treated? (4) What happens if amblyopia is untreated? Approved and selected by ophthalmologists (GW and DL), the keywords from AAPOS were words or phrases that deemed significant for the education of patients with amblyopia. The “Flesch-Kincaid Grade Level” formula, approved by the US Department of Education, was used to evaluate the reading comprehension level for the responses from ChatGPT, Google Assistant, and AAPOS.

Results

In their responses, ChatGPT did not mention the term “ophthalmologist,” whereas Google Assistant and AAPOS both mentioned the term once and twice, respectively. ChatGPT did, however, use the term “eye doctors” once. According to the Flesch-Kincaid test, the average reading level of AAPOS was 11.4 (SD 2.1; the lowest level) while that of Google was 13.1 (SD 4.8; the highest required reading level), also showing the greatest variation in grade level in its responses. ChatGPT’s answers, on average, scored 12.4 (SD 1.1) grade level. They were all similar in terms of difficulty level in reading. For the keywords, out of the 4 responses, ChatGPT used 42% (11/26) of the keywords, whereas Google Assistant used 31% (8/26).

Conclusions

ChatGPT trains on texts and phrases and generates new sentences, while Google Assistant automatically copies website links. As ophthalmologists, we should consider including “see an ophthalmologist” on our websites and journals. While ChatGPT is here to stay, we, as physicians, need to monitor its answers.
Digital Remote Monitoring Using an mHealth Solution for Survivors of Cancer: Protocol for a Pilot Observational Study (Preprint)
Authors: Innominato Pasquale F , Macdonald Jamie H , Saxton Wendy , Longshaw Laura , Granger Rachel , Naja Iman , Allocca Carlo , Edwards Ruth , Rasheed Solah , Folkvord Frans , de Batlle Jordi , Ail Rohit , Motta Enrico , Bale Catherine , Fuller Claire , Mullard Anna P , Subbe Christian P , Griffiths Dawn , Wreglesworth Nicholas I , Pecchia Leandro , Fico Giuseppe , Antonini Alessio
Published: April 2024

BACKGROUND

Healthy lifestyle interventions have a positive impact on multiple disease trajectories, including cancer-related outcomes. Specifically, appropriate habitual physical activity, adequate sleep, and a regular wholesome diet are of paramount importance for the wellness and supportive care of survivors of cancer. Mobile health (mHealth) apps have the potential to support novel tailored lifestyle interventions.

OBJECTIVE

This observational pilot study aims to assess the feasibility of mHealth multidimensional longitudinal monitoring in survivors of cancer. The primary objective is to test the compliance (user engagement) with the monitoring solution. Secondary objectives include recording clinically relevant subjective and objective measures collected through the digital solution.

METHODS

This is a monocentric pilot study taking place in Bangor, Wales, United Kingdom. We plan to enroll up to 100 adult survivors of cancer not receiving toxic anticancer treatment, who will provide self-reported behavioral data recorded via a dedicated app and validated questionnaires and objective data automatically collected by a paired smartwatch over 16 weeks. The participants will continue with their normal routine surveillance care for their cancer. The primary end point is feasibility (eg, mHealth monitoring acceptability). Composite secondary end points include clinically relevant patient-reported outcome measures (eg, the Edmonton Symptom Assessment System score) and objective physiological measures (eg, step counts). This trial received a favorable ethical review in May 2023 (Integrated Research Application System 301068).

RESULTS

This study is part of an array of pilots within a European Union funded project, entitled “GATEKEEPER,” conducted at different sites across Europe and covering various chronic diseases. Study accrual is anticipated to commence in January 2024 and continue until June 2024. It is hypothesized that mHealth monitoring will be feasible in survivors of cancer; specifically, at least 50% (50/100) of the participants will engage with the app at least once a week in 8 of the 16 study weeks.

CONCLUSIONS

In a population with potentially complex clinical needs, this pilot study will test the feasibility of multidimensional remote monitoring of patient-reported outcomes and physiological parameters. Satisfactory compliance with the use of the app and smartwatch, whether confirmed or infirmed through this study, will be propaedeutic to the development of innovative mHealth interventions in survivors of cancer.

CLINICALTRIAL

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/52957
Histofilosis en bovinos: microbiología, epidemiología y patología
Authors: Aguilar Romero Francisco , Suarez Guemes Francisco , Trigo Tavera Francisco José
Published: April 2024

La histofilosis es un grupo de enfermedades que padecen los rumiantes domésticos y silvestres, producida por Histophilus somni (antes Haemophilus somnus); una bacteria gram negativa, considerada un microorganismo patógeno oportunista que habita en las mucosas de los rumiantes. Afecta principalmente al tracto respiratorio y reproductivo, así como al sistema nervioso central, también se asocia a diversos trastornos generalizados como miocarditis, poliartritis, conjuntivitis, coroiditis, mastitis, epididimitis, otitis y septicemia. El objetivo de esta revisión es presentar información actualizada de este grupo de enfermedades que afecta a los bovinos, abordando las características del agente etiológico, sus principales factores de virulencia, aspectos epidemiológicos y la patogenia de la infección. Adicionalmente, se incluye la distribución de la enfermedad a nivel mundial, su diagnóstico, prevención y control.
A family of permutationally invariant quantum codes
Authors: Aydin Arda , Alekseyev Max A. , Barg Alexander
Published: April 2024

We construct a new family of permutationally invariant codes that correct t Pauli errors for any t≥1. We also show that codes in the new family correct quantum deletion errors as well as spontaneous decay errors. Our construction contains some of the previously known permutationally invariant quantum codes as particular cases, which also admit transversal gates. In many cases, the codes in the new family are shorter than the best previously known explicit permutationally invariant codes for Pauli errors and deletions. Furthermore, our new code family includes a new ((4,2,2)) optimal single-deletion-correcting code. As a separate result, we generalize the conditions for permutationally invariant codes to correct t Pauli errors from the previously known results for t=1 to any number of errors. For small t, these conditions can be used to construct new examples of codes by computer.
Hidden variable model for quantum computation with magic states on qudits of any dimension
Authors: Zurel Michael , Okay Cihan , Raussendorf Robert , Heimendahl Arne
Published: April 2024

It was recently shown that a hidden variable model can be constructed for universal quantum computation with magic states on qubits. Here we show that this result can be extended, and a hidden variable model can be defined for quantum computation with magic states on qudits with any Hilbert space dimension. This model leads to a classical simulation algorithm for universal quantum computation.
Complexity of Supersymmetric Systems and the Cohomology Problem
Authors: Cade Chris , Crichigno P. Marcos
Published: April 2024

We consider the complexity of the local Hamiltonian problem in the context of fermionic Hamiltonians with N=2 supersymmetry and show that the problem remains QMA-complete. Our main motivation for studying this is the well-known fact that the ground state energy of a supersymmetric system is exactly zero if and only if a certain cohomology group is nontrivial. This opens the door to bringing the tools of Hamiltonian complexity to study the computational complexity of a large number of algorithmic problems that arise in homological algebra, including problems in algebraic topology, algebraic geometry, and group theory. We take the first steps in this direction by introducing the k-local Cohomology problem and showing that it is QMA1-hard and, for a large class of instances, is contained in QMA. We then consider the complexity of estimating normalized Betti numbers and show that this problem is hard for the quantum complexity class DQC1, and for a large class of instances is contained in BQP. In light of these results, we argue that it is natural to frame many of these homological problems in terms of finding ground states of supersymmetric fermionic systems. As an illustration of this perspective we discuss in some detail the model of Fendley, Schoutens, and de Boer consisting of hard-core fermions on a graph, whose ground state structure encodes l-dimensional holes in the independence complex of the graph. This offers a new perspective on existing quantum algorithms for topological data analysis and suggests new ones.
A Review of Metaheuristic Optimization Techniques in Text Classification
Authors: Kaya Cem , Kilimci Zeynep Hilal , Uysal Mitat , Kaya Murat
Published: April 2024

Metaheuristic algorithms, inspired by natural phenomena and human-based strategies, offer versatile approaches to navigate diverse search spaces and adapt to dynamic environments. These algorithms, including evolutionary algorithms, swarm intelligence, bio-inspired methods, human-based approaches, and plant-inspired techniques, have found applications across diverse domains such as engineering, finance, healthcare, logistics, and telecommunications. In the text classification domain, metaheuristic techniques have emerged as powerful tools to enhance the accuracy, efficiency, and robustness of classification systems. By optimizing feature subsets, fine-tuning model parameters, and addressing challenges such as feature selection, dimensionality reduction, class imbalance, and noisy data, metaheuristic algorithms provide flexible solutions that adapt to various text datasets and tasks. This review paper comprehensively explores recent advancements in metaheuristic applications in text classification across six categories. From evolutionary-based methods to swarm-based approaches, bio-inspired techniques to physics/chemistry-based strategies, human-based methods to plant-based algorithms, researchers have leveraged diverse metaheuristic techniques to push the boundaries of text classification. Through a systematic analysis of recent research studies, this review provides insights into the strengths, limitations, and future directions of metaheuristic optimization in the context of text classification.
PROBLEM-BASED LEARNING, STRATEGI METAKOGNISI, DAN KETERAMPILAN BERPIKIR TINGKAT TINGGI SISWA
Authors: Sastrawati Eka - , Rusdi Muhammad - , - Syamsurizal -
Published: April 2024

The present study investigates effect of Problem-Based Learning (PBL) model and metacognition strategies on higher-order thinking skill of students in Mathematics Lesson. The independent variables are PBL design instructional and the expository and discussion learning design. The moderator variable is metacognition strategies measured by the adaptation OLRc News 2004. Questionnaires and structured-essay tests are used as research instruments. The dependent variable is higher-order thinking skills of Secondary school students. The experiment uses 2 x 2 factorial design with pretest and posttest. The samples are splitted into two groups: the PBL group and the conventional group of 32 students of each group. The study reveals that there are (1) the influence of the PBL model on higher-order thinking skills, (2) the influence of metacognition strategies on higher-order thinking skills, (3) the influence of PBL model on higher-order thinking skills of a group of students with high metacognition strategies, (5) there is an interaction between the PBL models and metacognition strategies against studentsâ€™ high-level thinking skills. Keywords: problem based learning, metacognition strategy, higher-order thinking skills
Transforming public sector operations with enterprise resource planning: Opportunities, challenges, and best practices.
Authors: Pontoh Grace Theresia , Indrijawati Aini , Handayanto Arga Bhayangkara , Tahang Rahmawansyah Andi , Supardi Try Sutriani
Published: April 2024

The public sector has long been criticized because the private sector is often considered more advanced and efficient in achieving its goals. Technological improvements in the public sector are needed to provide benefits to the wider community, one of which is by adopting systems used by advanced companies such as enterprise resource planning (ERP) systems. The purpose of this research is to provide insight into how ERP systems can be used to provide improvements in the public sector. This article uses a systematic literature review to synthesize the benefits and challenges and provides examples of best practices for implementing an ERP system in the public sector. The results show that ERP stands as an essential technical solution to achieve accountability and transparency in the public sector. The public and private sectors differ in the accessibility and disposal possibilities of resources, thus to overcome these challenges, the public sector needs to be guided by the implementation of best practices. The relatively low number of available Scopus-indexed research articles that focus on ERP in the public sector shows that the ERP literature has not developed well in the public sector.
Three Types of Isocoumarins with Unusual Carbon Skeletons from Artemisia dubia var. subdigitata and Their Antihepatoma Activity
Authors: Yang Ke-Xin , Li Tian-Ze , Ma Yun-Bao , Wang Yong-Cui , Li Feng-Jiao , Chen Jijun
Published: April 2024

Ten novel isocoumarins, including four pairs of enantiomers, were
isolated from Artemisia dubia var. subdigitata (Asteraceae). Com-pounds
1, 2 and 3a/3b possessed a unique 6/6/6-tricyclic system comprising an
unusual 1-(2-methylcyclohexyl) propan-1-one moiety fused with
isocoumarin core skeleton. Compounds 4a/4b were characterized as an
unexpected 2,5-dimethylcyclohexan-1-one scaffold, and compounds 5a/5b
and 6a/6b were rare 1,2-seco-isocoumarin. Their structures and absolute
configurations were elucidated through spectroscopic data, X-ray
crystallography, ECD and NMR calculations with DP4+ analyses. Plausible
biosynthetic pathways were proposed from the naturally occurring
isocoumarin. Network pharmacological analysis suggested that the targets
of compound 1 were significantly enriched in the cell cycle and PI3K-Akt
signaling pathway. The molecular docking revealed that compound 1 had
high binding affinity with CDK2 (total score: 6.8717). Furthermore,
compounds 1 and 2 exhibited inhibitory activity on three human hepa-toma
cell lines, with inhibitory ratios of 85.1% and 84.5% (HepG2), 88.2%
and 87.3% (Huh7), and 69.2% and 69.1% (SK-Hep-1) at 200 μM,
respectively.
Asociación entre lesiones periapicales y diabetes mellitus
Authors: Garchitorena María Inés , Andrade Ernesto , rodriguez baleato Adriana Beatriz
Published: April 2024

Las lesiones periapicales son procesos inflamatorios que generan la reabsorción de los tejidos mineralizados. En pacientes diabéticos este proceso puede verse afectado. Este trabajo tiene como objetivo identificar la asociación entre la diabetes mellitus y las lesiones periapicales y conocer si los pacientes diabéticos presentan mayor prevalencia y severidad. Se realizó una revisión amplia de la literatura disponible, de tipo narrativa. Se consultaron las bases de datos PubMed (Medline) y SciELO y los recursos Timbó y Google Scholar. Los criterios de exclusión fueron: trabajos anteriores al año 2010 y reportes de caso Se incluyeron artículos anteriores a la fecha de exclusión por considerarse relevantes para el trabajo. A pesar que la evidencia científica continúa siendo insuficiente y el diseño de los estudios debe mejorarse, se demuestra asociación entre lesiones periapicales y diabetes mellitus. Esto implica que los pacientes diabéticos podrían presentar mayor prevalencia y severidad de lesiones.
A study on fire data augmentation from video/image using the similar-label and F-guessed method
Authors: Kim Jong-Sik , Kang Dae-Seong
Published: April 2024

When data collection is limited, such as in the case of fire detection, improving the detection rate with only number of small labeled data is difficult. Therefore, researchers have conducted many related studies, among which semisupervised learning methods have achieved good results in improving detection rates. Most recent semi-supervised learning models use the pseudo-label method. But there is a problem, which is that it is difficult to label accurately in samples that deviate from the true label distribution due to false labels. In other words, due to the pseudo-label used for data augmentation, erroneous biases can be accumulated and adversely affect the final weights. To improve this, we proposed a method of generating Similar-labeled data (prediction result labeling value and correct answer value are similar), which was used through the F-guessed method and the Region of Interest (ROI) expression method in the video during initial learning. This has the effect of preventing the bias from being distorted in the initial stages. As a result, data generation increased by about 6.5 times, from 5,565 to 41,712, mAP@0.5 increased by about 26.1%, from 65.9% to 92.0%, and loss improved from 3.347 to 1.69, compared to the initial labeled data.
Guest editorial: Deep learning techniques in intelligent internet of things and 5G communication networks
Authors: Chang Jia-Wei , Lin Nigel , Zhou Qingguo , Hsieh Yi-Zeng , Ivanovic Mirjana
Published: April 2024

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Determination of the construction material for phononic band gap structures by tribological performance
Authors: Yaman Paşa , Türkeş Erol , Yuksel Osman
Published: April 2024

This study investigates the tribological performances of commonly used stainless steel alloys (303, 304, 316L, and 420) to determine their suitability as construction materials for periodic structures designed for inertial amplification induced phononic band gap vibration isolators. Stainless steel alloys are extensively employed in engineering structures due to their ability to withstand large stresses and exhibit excellent cyclic loading properties. In this study, stainless steel specimens are examined by dry and lubricated wear test conditions. 420 stainless steel showed highest wear resistant properties for dry and lubricated conditions. Two grades of lubricants are compared in terms of viscosities, and it is revealed that higher viscosity blocked the flow of the lubricant so that semi-dry friction occurred. Low viscosity lubricant enabled less material removal due to friction.
The construct validity and internal consistency of QuickDASH in pediatric patients with upper extremity fractures
Authors: Kämppä Niko , Hulkkonen Sina , Grahn Petra , Laaksonen Topi , Repo Jussi
Published: April 2024

Background and purpose: Investigation of treatment options in the pediatric population necessitates the use of valid patient-reported outcome measures (PROMs). We aimed to assess the construct validity and internal consistency of the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) in the pediatric population with upper extremity fractures treated both operatively and conservatively.Patients and methods: QuickDASH, along with several reference PROMs and objective outcome measures, was obtained from 148 5- to 18-year-old patients with a humeral medial epicondyle fracture or a fracture of the distal forearm in a cross-sectional setting with a single follow-up visit. Spearman’s rank correlation and linear regression models were used to assess convergent validity, exploratory factor analysis (EFA) to assess structural validity, and Cronbach’s alpha to investigate internal consistency. Results: The direction and magnitude of correlation showed by QuickDASH with reference outcome measures was consistent and demonstrated good convergent validity. EFA indicated a 3-factor model with poor fit indices and structural validity remained questionable. Construct validity was considered acceptable overall. QuickDASH demonstrated good internal consistency with an acceptable Cronbach’s alpha (α = 0.75).Conclusion: QuickDASH demonstrated acceptable construct validity and good internal consistency and is thus a valid instrument, with some limitations, to assess disability and quality of life in pediatric patients with upper extremity fractures.
Educación STEAM (Ciencia, Tecnología, Ingeniería, Artes y Matemáticas) en la educación básica: integración curricular y efectividad, una revisión desde la literatura
Authors:   Instituto Universitario Rumiñahui. Quito, Ecuador, Arias Villalba Walter Oswaldo , Mejía Carrillo Manuel de Jesús ,   Universidad Pedagógica de Durango, Durango, México, Carranza Basantes Sergio Francisco ,   Universidad de Especialidades Turísticas UDET. Quito Ecuador, Alvarado Jaya Henry Gonzalo ,   Universidad Regional Amazónica IKIAM. Tena. Ecuador
Published: April 2024

La Educación STEAM, integrando Ciencia, Tecnología, Ingeniería, Artes y Matemáticas, destaca como enfoque pedagógico innovador que busca una integración holística de disciplinas. Proporciona a los estudiantes experiencias educativas más ricas y contextualmente significativas, superando la enseñanza tradicional. Este concepto promueve la interconexión entre áreas, reconociendo la relevancia de preparar a los estudiantes para un mundo interdisciplinario y tecnológico en constante evolución. Los objetivos de nuestro trabajo de revisión bibliográfica son la de analizar la literatura existente sobre la integración curricular de la Educación STEAM en la educación básica; evaluar la efectividad de la Educación STEAM en el desarrollo de habilidades cognitivas y socioemocionales en los estudiantes de esta etapa educativa y la de identificar desafíos comunes y oportunidades para la implementación exitosa de la Educación STEAM en contextos de educación básica. La metodología que llevamos a cabo fue la de una revisión bibliográfica sobre la Educación STEAM en la educación básica. Los resultados y discusiones evidencian la efectividad de la Educación STEAM y su impacto educativo al fomentar la integración disciplinaria y promover habilidades cruciales como el pensamiento crítico y la creatividad. También resalta el impacto positivo de STEM en la preparación laboral.
Feasibility of SWBSEA Application In Learning At Istiqlal Senior High School
Authors: Ningrum Dita Dwi , Siregar Alkhafi Maas
Published: April 2024

Practical methods are very rarely used in learning physics so that Students have difficulty understanding concepts. Student Worksheets are needed to support practical work. Student Worksheets used in learning are not feasible. Fulfillment of the feasibility test in learning in this study is intended to test and determine the level of feasibility of Student Worksheets Based on the Starter Experiment Approach (SWBSEA). The design of the SWBSEA is based on curriculum needs, Student knowledge, and Student skills. Testing the level of feasibility and application of SWBSEA is given to Students during learning and submits a questionnaire to assess the feasibility of use. The results showed that SWBSEA in Physics learning was considered feasible in terms of Content Display, Subject Display, Component Completeness, and Grammar.
Moderating role of board gender diversity and firm size on the relationship between free cash flow and corporate sustainability of Thai listed companies
Authors: Pasalao Sunanta , Boonyanet Wachira , Tongkong Supa
Published: April 2024

This study seeks to explore the information value of free cash flow (FCF) on corporate sustainability and investigate the moderating effects of board gender diversity and firm size on the association between FCF and corporate sustainability of Thai listed companies. The dataset consists of companies listed on the Stock Exchange of Thailand (SET) in 2022. Multivariate regression analysis is executed in this study. Subsequently, PROCESS macro served to evaluate the proposed hypotheses. This study found that FCF has a significant positive relationship with corporate sustainability. As well, board gender diversity and firm size both moderate the relationship between FCF and corporate sustainability, such that the positive effect of FCF on corporate sustainability is stronger when the proportion of female boards diminishes, while firm size is smaller. However, when firms have a larger proportion of females on the boards of directors for all levels of firm size, free cash flow indicates that there is no statistically significant effect on corporate sustainability. This study contributes to FCF and sustainability literature by understanding the extent of corporate sustainability.
La prostitución en el Nuevo Mundo: Tres cortesanas de Potosí, “La Babilonia de las Indias”
Authors: Zinni Mariana
Published: April 2024

Este artículo comienza con un breve repaso de la invisibilidad crítica y bibliográfica, aunque no cronística, literaria o artística, de la prostitución como actividad comercial durante la América virreinal, en particular en la ciudad de Potosí, Bolivia. Analizaré los casos de tres cortesanas célebres y sus escandalosas carreras en la Villa Imperial: Laureana, doña Estefanía, y doña Clara «La Achacosa», para ilustrar la presencia de estas mujeres y su participación tanto en la economía moral como en la cultura material de la época.
El oficio de maestra en la Málaga del XVIII
Authors: Vales-Villamarín Navarro Helena , Mocchi Beatriz
Published: April 2024

Las exigencias sucesivas a las que estuvieron sometidas las maestras y las redes de escuelas existentes en la Málaga del Antiguo Régimen no responden a situaciones independientes unas de otras sino que muestran un proceso de evolución muy lento y sin una política educativa concreta por parte del Estado. Este artículo se centra en la evolución del proceso de cualificación de las maestras de Málaga. Para poder superar la falta de fuentes, hemos centrado la investigación en la información disponible en el Archivo Histórico Nacional y en el Archivo Municipal de Málaga, de donde hemos recopilado todo lo relativo a las maestras de Málaga en el período de tiempo señalado. Los documentos encontrados confirman la existencia de una administración educativa, de carácter informal y bastante rudimentaria, en la que reinaba la desigualdad legislativa y social entre maestras y maestros.
Veterinary anesthesia: an opportunity to reduce the environmental footprint of clinical care
Authors: Viola Lindsey , Quintana Joedy , Sanchez Valeria , Scott Danielle , Griffenhagen Gregg M. , Duncan Colleen
Published: April 2024

Volatile anesthetic agents are potent greenhouse gases with warming potential hundreds to thousands of times greater than CO2. As health systems, both human and veterinary, seek to reduce their environmental impacts, responsible anesthetic stewardship is a topic of great interest. Through an online survey, we explored the levels of awareness, beliefs, interest, needs, and current actions of veterinary anesthesia professionals around the climate impacts of anesthetic care. We found that even within a respondent group with specialized training and experience, there were significant knowledge gaps about anesthesia’s environmental impacts. We also found there is much interest in learning more about climate-friendly anesthesia and broader sustainability initiatives for the veterinary profession. Fortunately, there already exist many ways for the profession to reduce our environmental impact while still providing excellent patient care. In this article, we explore 5 broad categories of action: (1) reducing the overall quantity of anesthetic agent used; (2) choosing lower-impact anesthetics; (3) considering the fate of the anesthetic end product; (4) expanding learning through formal education, experience, and research; and (5) reaching beyond anesthesia to implement a range of sustainability initiatives at veterinary workplaces. Together, we have an opportunity to create a healthier future for our world, our patients, and each other.
Involvement of veterinary students in the placement of intravenous catheters in adult horses in a teaching hospital does not significantly increase the rate of catheter complications
Authors: Hepworth-Warren Kate L. , Erwin-Craig Sara J. , Love Kim
Published: April 2024

OBJECTIVE

To determine whether student involvement in intravenous catheter (IVC) placement increases the risk for complications and to report the rate and types of complications associated with IVCs in adult horses in a university teaching hospital.

ANIMALS

455 IVCs placed in 394 horses.

METHODS

Data relevant to IVC placement and removal were retrieved from an electronic medical record search including records of adult horses from January 1 to December 31, 2022. Data retrieved from records included the role of the individual who prepared the site and placed the IVC, site of IVC placement, and type of IVC. The reason for removal of the IVC and presence or absence of detectable changes within the vein at the time of removal were documented in addition to clinical data, allowing for classification of each case. Data were reviewed retrospectively, and statistical analyses were performed using mixed-effects logistic regression models. Significance was set at P ≤ .05.

RESULTS

The overall rate of complications was 15.6%, and the most common type of complication was swelling of the vein. Students were involved in 87 of 455 IVC site preparations and placements, and there were no statistically significant differences in complication rates between IVC sites prepared or placed by veterinary students versus nonstudent personnel.

CLINICAL RELEVANCE

Veterinary personnel and clients may be hesitant to allow student involvement in IVC placement in horses, but these data suggest that student involvement does not increase the risk of IVC complications.
A ventral diaphragmatic advancement technique to repair a large congenital peritoneopericardial diaphragmatic hernia in a dog
Authors: Hennet Julie , Field Elinor
Published: April 2024

OBJECTIVE

To report a ventral diaphragmatic advancement technique to repair a large congenital peritoneopericardial diaphragmatic hernia in a dog.

ANIMAL

A 5-month-old 15-kg entire male Labrador Retriever.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES

The dog presented with a history of diarrhea for a week and acute-onset lethargy and vomiting for 3 days. Clinical examination revealed borborygmi on auscultation of the chest, and subsequent imaging showed a congenital peritoneopericardial diaphragmatic hernia.

TREATMENT AND OUTCOME

The ventro-central diaphragmatic defect was repaired with a pericardial flap, which subsequently failed 7 months later. The revision surgery was performed with a novel surgical technique. The defect was closed by means of incising the ventral attachments of the diaphragm either side of the defect and sliding it medially to allow a tension-free closure. The ventral aspect of the incised diaphragm was reattached with circumcostal sutures and the central defect closed. The dog recovered rapidly and without complication. An excellent outcome was reported after surgery.

CLINICAL RELEVANCE

This novel technique was a simple method to repair a peritoneopericardial diaphragmatic hernia and had good clinical results in this case.
Optimization analysis of blockchain technology in enterprise digital financial management
Authors: Liu Fuling , Li Ruiyao
Published: April 2024

The rise of mobile Internet has not only changed the business model of many enterprises, but also had a profound impact on the financial management model of enterprises. Based on this, this paper applies blockchain technology to enterprise financial management, using decision trees and information entropy alignment to optimize and promote its digital transformation. Regarding optimizing financial management processes, blockchain technology converts the enterprise’s financial management data into a distributed ledger. It integrates it with information entropy to create a digital financial data decision tree. This paper takes enterprise A as the research object, after optimizing the financial management process with blockchain technology, enterprise A’s financing ability is enhanced, and the current ratio as a whole maintains an upward state, reaching a maximum value of 0.86 in 2021, and then it has been maintained at about 0.8, indicating that the optimized short-term solvency capacity has been significantly improved. The total debt amount of enterprises is decreasing yearly, falling to 35.26 billion yuan in 2023. The amount of owners’ equity has shown an upward trend and has remained at a high level of 25 billion yuan since 2021. Therefore, blockchain technology strengthens the financial management capabilities of enterprises and explores a feasible path to reduce investment risks.
A study of visual attention patterns of snow and ice athletes based on eye-tracking technology
Authors: Liu Pengyu , Zhang Hui
Published: April 2024

The visual system has a strong information processing ability, and visual attention tracking has various applications in various scenes. This paper mainly focuses on the sports scene of ice and snow far mobilization. It constructs a visual attention system model based on eye tracking. It first establishes an eye tracking system framework using deep learning, and improves the gaze estimation by optimizing the feature extraction network. The visual attention system model was constructed using particle filtering based on motion feature cognition. In the eye-tracking visual attention system model experiments, the Accuracy of the improved eye-tracking system in this paper can be significantly improved to 1.13°, and the error of the visual attention system can be kept within 10°. Furthermore, the four ice and snow sports scene types have an average accuracy of 85.47%, and the constructed model performs well. This study offers a guide for effectively combining eye tracking technology and visual attention.