bluuebunny/crossref_metadata_2025 huggingface dataset:
An Interpretable Boosting-based Predictive Model for Transformation Temperatures of Shape Memory Alloys
Authors: Hossein Zadeh Sina , Behbahanian Amir , Broucek John , Fan Mingzhou , Vazquez Tovar Guillermo , Noroozi Mohammad , Trehern William , Qian Xiaoning , Karaman Ibrahim , Arroyave Raymundo
Published: February 2023

In this study, we demonstrate how the incorporation of appropriate feature engineering together with the selection of a Machine Learning (ML) algorithm that best suits the available dataset, leads to the development of a predictive model for transformation temperatures that can be applied to a wide range of shape memory alloys. We develop a gradient boosting ML surrogate model capable of predicting Martensite Start, Martensite Finish, Austenite Start, and Austenite Finish transformation temperatures with an average accuracy of more than 95% by explicitly taking care of potential distribution changes when modeling different alloy systems. We included heat treatment, rolling, extrusion processing parameters, and alloy system categorical features in the model input features to achieve more accurate and realistic results. In addition, using Shapley values, which are calculated based on the average marginal contribution of features to all possible coalitions, this study was able to gain insights into the governing features and their effect on predicted transformation temperatures, providing a unique opportunity to examine the critical parameters and features in martensite transformation temperatures.
Development and Application of Converter COMI-B Technology: A New Way of CO2 Utilization
Authors: Feng Chao , Dong Jianfeng , Zhu Rong , Yang Huapeng
Published: February 2023

CO2 has characteristic properties and reactions at converter smelting temperature, and the chemical reaction between CO2 and elements such as C and Si in the molten pool has bubble proliferation and cooling effects, which can effectively improve the kinetic and thermodynamic conditions of converter smelting. Here, an experimental study and industrial test on the application of CO2 in converter smelting were carried out. The smelting effects of Mode-1 and Mode-2 with total CO2 injection amounts of 229 Nm3 and 196 Nm3, respectively, were compared, and the changes in molten steel and slag compositions, dust removal, and gas are analyzed. The test results show that converter top and bottom blowing CO2 technology (COMI-B)technology had significant metallurgical advantages over the N-Mode; the dephosphorization rate increased by 4.2%, slag (FeO) content was reduced by 2.04%, end point nitrogen content of molten steel was reduced by 20%, gas recovery increased by 8.29 Nm3/t, and soot production reduced by 14.7%. The results of the study provide reference for the application of COMI-B technology in converters in the iron and steel industry and develop a new path for resource utilization of CO2.
Kecemasan Berbahasa untuk Ketrampilan Berbicara Bahasa Arab pada Tingkatan Perguruan Tinggi
Authors: Alfian Muhammad Ivan , Niswah Nujumun , Masykur Muhammad Zakki
Published: February 2023

Speaking anxiety is a common phenomenon in foreign language teaching, but if this anxiety and fear continue to include students, the goal of learning to speak, namely to improve oral competence in Arabic, will be difficult to achieve. Therefore, this study aims to describe: (1) the level of language anxiety in Arabic speaking skills, (2) the factors that cause language anxiety in students' speaking skills, and (3) strategies that can be pursued to overcome language anxiety in students. student speaking skills. This research uses qualitative and quantitative methods (mixed methods) using questionnaires and interviews in collecting data. The results showed that: (1) that the students' anxiety was at the high level with a score of 2.69. (2) The factors that cause anxiety are quite diverse, including students' perceptions of speaking skills; the complexity of the Arabic language; lack of mastery of Arabic; do not master the topic of conversation; worried about getting bad ratings; lecturer assessment; and insecurity.
Al-Ansyiṭah al-Lugawiyyah fī Barnāmaj al-Mukhayyam al-'Arabī bi Ma’had li al-Banāt Darussalam Gontor Mantingan Ngawi
Authors: Yasin Agus , Rahmah Firda Amalia
Published: February 2023

The purpose of this study, to find out the language activities in the Al-Mukhayyam Al-‘Arabiy improved speaking skills at Modern Islamic Boarding School Darussalam Gontor For Girls 1. The researchers saw this event had succeeded in shaping the environment and make them proficient in speaking Arabic every day. Many advantages of this event, researchers want to know more about what kinds of activities held in the event. This research is a qualitative research. In collecting data, the researcher used 3 methods, namely the documentary method, the interview method and the observation method. In data analysis, the method used is Miles and Hubberman. The results of the research, among the linguistic activities in the event are speeches, Arabic debates, Arabic broadcasts, poetry, listening, insya, dobtul papers, nahwu and shorof. And the events that can improve speaking skills are speeches, Arabic debates, Arabic broadcasts, poetry, nahwu and shorof.

 
Traducción del Éxodo (inglés antiguo>español) con el inglés contemporáneo como lengua pivote con fines didácticos
Authors: Tinedo Rodríguez Antonio Jesús
Published: February 2023

La combinación de la traducción diacrónica con la traducción interlingüística es aún un campo inexplorado y de gran interés debido a la información sociocultural y lingüística que podemos obtener de los textos escritos en el pasado. Este estudio se centra en la primera parte de El Éxodo, que es un poema de devoción que se encuentra en uno de los códices más importantes de la lengua inglesa, el Manuscrito de Junius. El objetivo principal es traducir al español la primera parte del poema conocido como ‘El pacto del Señor con Moisés’. Para ello, el primer paso ha sido traducir el texto del inglés antiguo al inglés actual y, en segundo lugar, del inglés actual al español. Hay objetivos subsidiarios como comprender cómo evolucionan las metáforas conceptuales con el lenguaje centrándose en el caso particular de los kennings. El trasfondo literario del texto jugará un papel fundamental porque ayudará a comprender la relación del poema con otros poemas publicados en inglés antiguo.
DESAFÍOS PARA LA EDUCACIÓN SUPERIOR INTERCULTURAL BILINGÜE. LA UNIVERSIDAD NACIONAL INTERCULTURAL DE LA SELVA CENTRAL “JUAN SANTOS ATAHUALPA” EN PANDEMIA DEL COVID-19
Authors: Landeo Minaya Karina Lisbeth
Published: February 2023

En el marco de la modalidad virtual de las clases y trabajo remoto, son profundos los cambios impuestos tras el estado de emergencia sanitaria y confinamiento decretado por la pandemia del COVID-19. En este contexto, el objetivo de este trabajo consiste en identificar fortalezas, debilidades y prospectivas en la enseñanza bajo la modalidad no presencial en la Universidad Nacional Intercultural de la Selva Central “Juan Santos Atahualpa” (UNISCJSA), en Perú. La metodología de este estudio aborda un enfoque cualitativo sobre una muestra de 66 estudiantes de un total de 140 de la Escuela Profesional de Educación Intercultural Bilingüe (EPEIB). Entre los principales resultados, se destaca dos fases de la ‘Educación Remota de Emergencia’; una para enfrentar la cuarentena y la otra, con la asistencia del gobierno peruano a través del programa PMESUT, el cual capacitó a los docentes de las universidades públicas bajo ciertos parámetros. El análisis de los resultados en los estudiantes, destacan que un 30% ingresan regularmente a la plataforma Teams en forma sincrónica, ninguno activa sus cámaras al momento de intercambiar comunicación, pues el principal problema que afrontan es la conectividad. A su vez, durante las sesiones los estudiantes realizan actividades diversas, como el cuidado de menores a su cargo. Un alto porcentaje escucha sus clases por celular. Las conclusiones a las que podemos arribar establecen que, la educación en tiempos de pandemia se ve reflejada en una realidad incierta, pues la reproducción del saber desnaturaliza los aprendizajes de los estudiantes de las comunidades nativas, jóvenes de habla quechua, ashaninka, asheninka, yanesha, nomatsigenga y kakinte, quienes no desarrollaron experiencias educativas en su idioma materno, siendo este el primer indicador del bilingüismo y fundamento pedagógico según él Diseño Básico Curricular Nacional de la Formación Inicial Docente del Programa de estudios de Educación Intercultural Bilingüe (2018). Finalmente, la UNISCJSA en este periodo no estuvo adaptada a la educación en la modalidad virtual, sino que lo aplicado fue la Educación Remota de Emergencia (ERE) que, no incluyó la innovación tecnológica y pedagógica.
Concepto y representación de la vejez en el medievo. Aproximación a los mayores de la Córdoba del siglo XV
Authors: Navarro Gavilán Blanca
Published: February 2023

Este artículo analiza la consideración que existió de los ancianos a finales del Medievo, indagando sobre las distintas etapas de la vida, la representación iconográfica de la vejez y las edades que alcanzaron reyes peninsulares y papas medievales. Sin olvidar los cambios socioeconómicos y demográficos provocados por la Peste Negra y epidemias siguientes, que inclinaron la balanza hacia los ancianos, los grandes supervivientes. Algunos mejoraron su situación, mientras otros –especialmente las viudas- acabaron en centros asistenciales como hospitales o se retiraron a monasterios, donde pasarían los últimos días de sus vidas. Por último, se examina el trato recibido por los mayores en la Córdoba del siglo XV y las relaciones existentes con el resto de generaciones.
Enclaves fortificados y poblamiento medieval en la Sierra del Águila (Hornachuelos): los castillos del «Comendador», de «Comares» y la torre de «Casa Fuerte»
Authors: Navarro Martínez Emilio José
Published: February 2023

El trabajo de campo, esencial para la investigación histórica tiene especial complejidad en el ámbito de la Sierra del Águila. En esta zona de difícil acceso se conservan las ruinas de los castillos del Comendador, de Comares y  de la torre de Casa Fuerte. Estos enclaves fortificados se convierten en los principales restos arqueológicos de la  articulación del territorio durante la alta y plena Edad Media, en el curso medio y alto del río Retortillo.
Experimentación arqueológica de recetas técnicas de fabricación de la pasta de cera para sellar documentos. Siglos XIV-XVI
Authors: Hidalgo Rafael Javier Díaz
Published: February 2023

Los sellos fueron, durante las Edades Media y Moderna, documentos de un valor comparable a los escritos a los que se presentaban unidos. Hasta el momento no se han realizado trabajos dedicados al estudio de la composición y fabricación de sellos. Después de realizar el análisis de una receta de cera gomada de la Biblioteca Nacional de España, se vio necesario realizar su proceso de experimentación arqueológica y de otras fórmulas de origen hispano e italiano, ya publicadas, a fin de comprobar si lo descrito posee una aplicación técnica real.
INDUSTRI KELAPA INDONESIA: KINERJA DAN PERSPEKTIF PENGEMBANGAN MENUJU PENINGKATAN NILAI TAMBAH DAN DAYA SAING
Authors: Hestina Juni , Purba Helena J , Yusuf Eddy , Dabukke Frans B.M. , Erwidodo NFN , Azhari Delima , Darwis Valeriana
Published: February 2023

Coconut commodity has a strategic role in the country's foreign exchange earnings, providing employment and increasing farmers' income. In 2020 the value of Indonesia's coconut exports reached US$890 million, with a total export volume of 1.8 million tons. The most significant export value is processed coconut oil, namely crude coconut oil and semi-finished coconut oil, by 50% of other processed coconut products. The export value of processed crude coconut oil was 29% or US$254.9 million, and semi-finished coconut oil was 21% or US$188.1 million. This paper reviews the performance and problems of coconut Indonesia's industry and identifies opportunities for its development. The coconut industry performance faces problems from upstream to downstream. The upstream problems are low productivity, old plants, limited capital resources, damaged plants, and decreasing land area. The downstream issues are the lack of innovation in coconut products, fresh coconuts dominating coconut exports, and the decline in export performance for processed products of crude oil and semi-finished oil. Innovation and technology are necessary to enhance the coconut industry's performance. Produce ready-to-use products that are increasingly in demand in global and domestic markets. Productivity improvements, production costs, and quality are determinants of the competitiveness and yield of coconut exports.
Las bebidas energizantes para mejorar el rendimiento físico en los jóvenes que realizan deportes, Ate – Vitarte, Lima, Perú, 2021
Authors:   , Lazo Pongo Luz María , León Gonzales Fritz Anderson , Baldeón Carhuaricra Esthefania Brijhit
Published: February 2023

El actual proyecto se centra en el desarrollo y lanzamiento de bebidas energéticas naturales llamado Power Ink, el cual es creado usando las siguientes combinaciones de Sanki, Maca Negra, Chía, Hoja de Coca, endulzantes y preservantes naturales. Está dirigido para los consumidores con un nivel socioeconómico B y C, en la cual quieren una vida saludable y natural, no solo busca necesidades de rehidratación, también que pueda ayudar con el aumento de energía, la resistencia física, mental y una buena concentración. La idea es dar como resultado un producto 100% natural con un mayor nivel nutricional y antioxidante, es una opción viable para la población, ya que es una bebida energizante, también puede contribuir como una ayuda medicinal. Aprovechar la alta demanda que tiene el mercado de bebidas energéticas que ha experimentado un continuo crecimiento en los últimos años, en este caso se dan condiciones favorables para el lanzamiento de nuestro producto. Se desarrolló un plan estratégico para el estudio el cual considera los lineamientos requeridos para su producción, distribución y comercialización. Power Ink es un producto innovador que tiene los objetivos comunes donde se enfoca en el mercado objetivo y el mercado meta, el perfil de nuestros clientes, beneficios y rendimiento económico de nuestro proyecto.
La gestión financiera y rentabilidad de la empresa Market Circolo S.A.C. Chaclacayo, 2021
Authors:   , Ayala Ore Lorena Luisa , Navarro Quispe Kiara Maythe
Published: February 2023

La presente investigación se titula Gestión financiera y rentabilidad de la empresa Market Circolo S.A.C, distrito de Chaclacayo, 2021. La cual tuvo con objetivo analizar la relación de la gestión financiera con la rentabilidad de la empresa Market Circolo S.A.C, distrito de Chaclacayo, 2021, siendo la investigación de diseño no experimental transversal, tipo descriptivo, correlacional, enfoque cuantitativo. Para lograr el objetivo se aplicó un cuestionario a 40 trabajadores de la empresa objetivo de estudio. A partir del cual se llegó a concluir lo siguiente: La gestión financiera se relaciona con la rentabilidad de la empresa Market Circolo S.A.C, distrito de Chaclacayo, 2021. Es decir, con ello se logró analizar la relación que tiene la gestión financiera con la rentabilidad de la empresa, proporciono los indicadores que intervinieron y reconocieron las dimensiones, además logro tener en cuenta que las decisiones financieras al igual que la planificación financiera ayudaron a que la empresa tuviera una adecuada gestión financiera y esta se reflejó en la rentabilidad de la empresa.
Tecnologías de información y comunicación y desarrollo organizacional en el área comercial de una compañía peruana de seguros, 2022
Authors:   , Solari Legua Genesis Alejandra
Published: February 2023

La finalidad principal de la investigación fue determinar la relación entre las tecnologías de información y comunicación (TIC) y el desarrollo organizacional (DO) en el Área Comercial de una compañía peruana de seguros durante el 2022. La investigación se desarrolló bajo el enfoque cuantitativo, alcance correlacional y utilizó el diseño no experimental transeccional correlacional-causal; los participantes fueron 90 asesores comerciales de la compañía objeto de estudio, a los cuales se les aplicó un cuestionario tipo Likert compuesto por 16 ítems. Luego del procesamiento y análisis de la información, se halló una relación moderada y significativa entre las TIC y DO, dado que, se obtuvo un coeficiente de correlación de Spearman de 0.666.
Mapping cells to gene programs
Authors: Lotfollahi Mohammad , Rybakov Sergei , Hrovatin Karin , Hediyeh-zadeh Soroor , Talavera-Lopez Carlos , Misharin Alexander V , Theis Fabian J.
Published: February 2023

Single-cell data integration involves removing unwanted technical variations across multiple datasets. We introduce expiMap, an intepretable generative model that maps single cells to reference atlas1 and gene programs. Here, we describe a protocol for building an initial reference atlas, mapping new datasets as queries, and identifying gene programs that split between populations. This protocol is associated with our Nature Cell Biology paper describing this model: Biologically informed deep learning to query gene programs in single-cell atlases.
Passive Flow Control via Tip Grooving and Stall Fencing Mechanisms of a Marine Energy Harvesting Turbine
Authors: Islam Nazrul , Das Tapas K. , Samad Abdus , Pasha Amjad Ali , Alsulami Radi A.
Published: February 2023

Remarkable advancement in wave energy conversion technology has taken place in recent years. Due to its simplicity, the Wells turbine has been one of the most widely used power take-off mechanisms in an oscillating water column type wave-energy conversion device. However, the turbine suffers from several challenges due to its narrow operating range, which hinders the commercial feasibility of the system. Several aerodynamic applications have successfully used passive control methods to modify the flow conditions. This work applied a combination of stall fences and casing grooves for passive flow control of a Wells turbine. The computational fluid dynamics (CFD) technique is used to analyze the modified turbine numerically. The casing groove modified the tip-leakage vortices, interacted with local vortices created by the stall fences, and helped reattach the flow at higher flow coefficients. As a result, the modified turbine increases the operating range up to 33.3%. In addition, the peak-to-average (PTA) power ratio decreased by up to 27.7%.
Managing pain in people with Crohn's Disease: study protocol for a feasibility testing of an Acceptance and Commitment Group Therapy intervention.
Authors: Czuber-Dochan Wladyslawa , Watson Natalie , Mawdsley Joel , Kent Alexandra , Duff Alexa , Moulton Calum , Norton Christine
Published: February 2023

This study will assess the feasibility of a group-based Acceptance and Commitment Therapy (ACT) intervention to reduce the impact of abdominal pain and its associated psychological burden in people with Crohn’s disease (CD).
Background: Chronic abdominal pain is a common symptom for patients with Crohn's disease, causing significant negative impact on their daily quality of life. Moreover, the pain does not consistently corelate with their disease activity, with almost half of patients experiencing significant levels of pain in remission. This lack of association between the disease and one of the prevalent symptoms is distressing for patients, and causes difficulty with medical management, as the strategies are unsatisfactory. An alternative approach is emerging in the use of psychological techniques such as Acceptance and Commitment Therapy (ACT) for chronic pain treatment in other conditions. This feasibility trial aims to explore whether this approach could be used in this population.
Methods: A cross over randomised control trial with quantitative and qualitative evaluation will be conducted. We will recruit 48 patients to take part in three waves of an ACT based group intervention for chronic abdominal pain with specific adaptations tailored to its presentation in Crohn's disease. In each wave, we will randomise to an active group who will engage in the group intervention first, and a wait-list control group, who will start the intervention later. Both groups will complete measures at baseline, week 8-10 and week 24 after randomisation with the crossover arm completing two additional sets after their intervention. Separately, participants will be asked to take part in a qualitative feedback interview with the lead researcher to discuss their experiences. This data will be analysed by the research team and patient representatives.
Discussion: We will measure the success of the recruitment (recruitment rates number of approached, eligible and consenting patients), participants’ willingness to be randomised, and to complete the study (follow-up questionnaire rates). Refusal, withdrawal, and dropout rates from the study will be recorded and calculated for both groups.
Utilization and contributing factors of sexual and reproductive health services in Ethiopia during COVID-19 pandemic፡ A systematic review and meta-analysis
Authors: Angaw Dessie Abebaw , Endehabtu Berhanu Fikadie , Gonete Tajebew Zayede , Dessie Kassahun , Jisso Meskerem , Tamiso Alemu , Yesuf Elias , Abera Netsanet , Abdisa Biru , Sime Habtamu , Yin Jessika ,   Kassu Ketema Gurmu4, Tilahun Binyam
Published: February 2023

Background: The COVID-19 pandemic has reduced access to and utilization of essential health services, including sexual and reproductive health services. The indirect supply-side and demand-side effects of the coronavirus pandemic has shown moderate service reduction scenarios can lead to a large number of additional maternal deaths
Objective: Determine the pooled proportion and contributing factors of sexual and reproductive health care in Ethiopia during the COVID-19 pandemic was the primary goal of this systematic review and meta-analysis.
Methods: The Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-2020) statement guided the conduct of this systematic review and meta-analysis. Electronic databases like SCOPUS, EMBASE, PubMed, and Science Direct were used to search for the papers. Studies were searched utilizing additional data sources such as Google scholar's advanced search and Google. The COVID 19 period and the latest search dates of June 6, 2022 were used for the primary research.
Heterogeneity was evaluated using I2 and Q-statistics. Wherever possible subgroup analysis was planned by study setting, and overall risk of bias (study quality). To test the small study effect; funnel plot and egger's test were applied in the Meta-analysis
Result: A total of six studies with 3848 participants included in this Meta-analysis. the pooled proportion of sexual and reproductive health service utilization reported by 6 studies was 32% (95%CI (18,46%)). In the sub group analysis, the pooled proportion of SRH service utilization for study done at the community level was 26% (95% CI:6-46%) and 38% (95% CI: 26-50%) among institutional based studies. Participants age 20-24 (OR=2.4 95% CI:1.07-5.3) Participate in youth club (OR=2.74; 95% CI:10.07-6.99), Ever had sexual partner (OR=1.65; 95% CI:1.11-2.45), Participated in peer-to-peer education (OR=1.71; 95% CI:1.12-2.62), and having pocket money (OR=2.5;3 95% CI:1.03-6.19) where variables had positively associated with sexual and reproductive health service utilization.
Conclusion: The pooled SRH service utilization in Ethiopia during COVID 19 was decreased compared to SRH service utilization before the pandemic. Participants age 20-24, Participate in youth, ever had sexual partner, participated in peer-to-peer education, and having pocket money where variables had positively associated with sexual and reproductive health service utilization.
A novel vibration-reduction motion planning method for fast moving mass traveling along flexible structures
Authors: Wang Xiaoming , Wang Enmei , Xing Jian , Zhou Wenya
Published: February 2023

Many classic components or equipment in the fields of aerospace, robotics, and civil engineering, can be classified into a flexible structure with moving components actively traveling on it, which constitutes a self-excited system and exhibits complex nonlinear dynamic coupling effects between the flexible substrate and moving mass. The excited structural vibration due to moving mass motion will bring challenges to the stability and mission effectiveness of the whole system, especially in the case of short-time and fast movement. Thereby, the paper presents analyses and optimization of the motion profiles of a moving mass traveling on a flexible simply supported beam with the goal of reducing the self-excited structural deflection and vibration. The dynamic responses imply that the moving mass would induce evident motion-induced dynamic deflection and residual vibration, and such effects highly depend on the motion profile. A high-efficiency motion planning approach is imposed by employing the quintic spline curve and Kriging surrogate model based optimization algorithm combined with the expected improvement infilling-sampling criterion. The favorable motion profiles can be found by using only 2 waypoints and approximately 100 samplings. In the case of minimization of the transient deflection amplitude, lower transient deflection, which is even lower than the static value, can be obtained using the optimized motion profile. In the case of minimization of residual vibration energy, a smooth deformation history of the substrate beam can be produced while the vibration energy has also been significantly reduced. Using the minimization of residual vibration energy as an objective function is recommended as a preferable way in the motion planning issue. Improved motion profiles with shorter terminal time are obtained and proved the effectiveness and robustness of the proposed optimization approach. The proposed approach and associated results could provide a feasible way to design a favorable moving mass motion from the perspective of vibration reduction for flexible structures.
Determining the drilling mud window by integration of geostatistics, intelligent, and conditional programming models in an Oilfield of SW Iran
Authors: Kianoush Pooria , Mohammadi Ghodratollah , Hosseini Seyed Aliakbar , Khah Nasser Keshavarz Faraj , Afzal Peyman
Published: February 2023

Accurate knowledge of pore and fracture pressures is essential for drilling wells safely with the desired mud weight (MW). Overpressure occurs when the pore pressure is higher than the normal hydrostatic pressure. There is a challenge regarding the pressure studies domain in an oilfield in SW Iran, where lack of geo-mechanical data limits exact mud window calculation. Also, the reservoir generally consists of carbonate rocks and contains no shale interbeds, so mechanical stratigraphy based on Gamma ray could not be applied. This study is to provide safe drilling considering MW to prevent the flow or loss in the vicinity of the new wells in the studied field. In this research the formation pressures and mud window models are determined by combining geostatistical, intelligent, and conditional programming models and compared with real data. The conditional programming was also used to correct small out-of-range data. The highest correlation between the final effective pressure and velocity cube was observed in lower Fahliyan Formation with 0.86 and Ilam with 0.71.The modeled MW difference ranged between 2.5 and 30 PCF. Also, the maximum modeled MW is 150 PCF in the upper Fahliyan Formation. Heavy mud of more than 130 PCF is suggested for drilling the Khalij member and continues to the end of stratigraphy column. Best observed correlation comparing the drilled and modeled MW, especially achieved in the Fahliyan reservoir Formation with more than 100 PCF and the Ilam Formation with 80-100 PCF. Finally, 3D formation pressures is presented and recommended for further safe drillings.
The DDUP protein encoded by the DNA damage-induced CTBP1-DT lncRNA confers chemoresistance in ovarian cancer
Authors: Ren Liangliang , Qing Xingrong , Wei Jihong , Mo Haixin , Liu Yuanji , Zhi Yaofeng , Lu Wenjie , Zheng Mingzhu , Zhang Weijian , Chen Yuan , Zhang Yuejiao , Pan Taijin , Qian Zhong , Li Ronggang , Zhang Xin , Ruan Xiaohong , Yu Ruyuan , Li Jun
Published: February 2023

Aberrant DNA damage response (DDR) signaling is one of major reasons underlying chemotherapy failure in cancer, and understanding the mechanism underlying aberrant DDR signaling would aid in developing novel strategies for overcoming cancer chemoresistance. The present study demonstrated that the expression of the DDUP microprotein, encoded by the CTBP1-DT lncRNA, increased in chemotherapy non-response ovarian cancer cells and was inversely correlated to platinum-based chemotherapy response. Using a patient-derived human cancer cell model, we observed that the formation of DDUP foci, which is induced by DNA damage, played an important role in platinum-based chemotherapy resistance through dual RAD51C-mediated homologous recombination (HR) and proliferating cell nuclear antigen (PCNA)-mediated post-replication repair (PRR) mechanisms. These mechanisms are mediated via interactions with RAD18/RAD51C and RAD18/PCNA complexes at the sites of DNA damage and sustained RAD18-mediated DNA damage signaling. Notably, treatment with an ATR inhibitor disrupted the DDUP/RAD18 interaction and abolished the effect of DDUP on prolonged DNA damage signaling, which resulted in the hypersensitivity of ovarian cancer cells to platinum-based chemotherapy in vivo. Altogether, the study provides insights into DDUP-mediated aberrant DDR signaling in cancer chemoresistance and describes a potential novel therapeutic approach for the management of platinum-resistant ovarian cancer.
Optimized interest forwarding in information centric vehicular networks using general secretary problem
Authors: Samantha Surya , Dutta Nitul
Published: February 2023

Vehicular networks of current era is not limited only to road safety and traffic management. It is been widely accepted as a network for information sharing, social networking and entertainment. With the advent of smart vehicles, the demand of vehicular network centric applications are getting popular. In one way, these applications demand faster data access and on the other hand, the underlying challenges of vehicular networks such as intermittent connectivity, low bandwidth and unpredictable vehicle movements impose considerable hindrance on communications. That is why, the vehicular communication is moving towards information centric approach so that the benefits of Information Centric Network (ICN) can be utilized. However, inherent challenges of vehicular communication and the lack of adequate protocols to implement content centric approach makes the extension of ICN into vehicular communications difficult. In ICN, a node generates interest packets to find a content. The interest is forwarded to an appropriate cache store to get the data. Hence, efficient forwarding of interest packets can considerably improve the content retrieval delay and can reduce network load. The interest forwarding techniques designed for wired ICN are not suitable for vehicular network due to computational complexity and bandwidth crisis. Hence, Information Centric Vehicular Network (ICVN) demands a new design for interest forwarding. Influenced by the need of the current time in vehicular communication, this research is aimed at developing an efficient interest forwarding mechanism for ICVN. The proposed algorithm models the interest forwarding task as a general secretary problem and finds the best node (or set of nodes) in the network to forward the interest packet. The protocol performance is examined in a simulation testbed designed in ndnSim-2.0 and compared with existing forwarding approaches. Observation demonstrates a better performance of the said vehicle with respect to content retrieval latency and network overhead.
Development and Validation of a Computed Tomography-Based Radiomics Signature to Predict “Highest-risk” From Patients with High-risk Gastrointestinal Stromal Tumor
Authors: Zheng Jiabin , Liao Qianchao , Chen Xiaobo , Hong Minping , Liu Zaiyi , Li Yong
Published: February 2023

Purpose
To develop and validate a preoperative enhanced CT-based radiomics nomogram for prediction of recurrence or metastasis in patients with high-risk gastrointestinal stromal tumor (GIST).
Method
100 high-risk GIST patients (training cohort: 60; validation cohort: 40) with preoperative enhanced CT images were enrolled. The radiomics features were extracted and a risk score was built using least absolute shrinkage and selection operator (LASSO)-Cox model. The clinicopathological factors were analyzed and nomogram was established with and without radiomics risk score. The concordance index (C-index), calibration plot, and decision curve analysis (DCA) were used to evaluate the performance of the radiomics nomograms.
Result
11 radiomics features associated with recurrence or metastasis were selected. The risk score was calculated and significantly associated with disease-free survival (DFS) in both training and validation group. Cox regression analysis showed that Ki67 was an independent risk factor for DFS (p = 0.004, HR 4.615, 95%CI 1.624–13.114). The combined radiomics nomogram, which integrated the radiomics risk score and significant clinicopathological factors, showed good performance in predicting DFS, with C-index of 0.832 (95% CI:0.761–0.903), which was better than the clinical nomogram (C-index 0.769, 95% CI: 0.679–0.859) in training cohort. The calibration curves and the decision curve analysis (DCA) plot suggested satisfying accuracy and clinical utility of the model.
Conclusion
The CT-based radiomics nomogram, combined with the clinicopathological factors and risk score, have good potential to assess the recurrence or metastasis of patients with high-risk GIST.
Validating virtual administration of neuropsychological testing in Parkinson disease: a pilot study
Authors: Weintraub Daniel , Gallagher Julia , Mamikonyan Eugenia , Xie Sharon , Tran Baochan , Shaw Sarah
Published: February 2023

Background
COVID-19 has highlighted the need for remote cognitive testing. Virtual testing may lessen burden and can reach a larger patient population. The reliability and validity of virtual cognitive testing in Parkinson disease (PD) is unknown.
Objectives
To validate neuropsychological tests for virtual administration in PD.
Methods
Participants enrolled in an observational, cognition-focused study completed a rater-administered cognitive battery in-person and via video conference 3–7 days apart. Order of administration was counterbalanced. Analyses to compare performance by type of administration (virtual versus in-person) included paired t-test, intraclass correlation (ICC) and linear mixed-effects models.
Results
Data for 35 (62.9% male) PD participants (62.5% normal cognition, 37.5% cognitive impairment) were analyzed. Only the semantic verbal fluency test demonstrated a difference in score by administration type, with a significantly better score when administered virtually (paired t-test p = 0.011 and linear mixed-effects model p = 0.012). Only the Dementia Rating Scale-2, Trails A test and phonemic verbal fluency demonstrated good reliability (ICC value 0.75–0.90) for virtual versus in-person administration, and values for visit 1 versus visit 2 were similarly low overall. Trail making tests were successfully administered virtually to only 18 (51.4%) participants due to technical issues.
Conclusions
Virtual cognitive testing overall is feasible in PD, and virtual and in-person cognitive testing generate similar scores at the group level, but reliability is poor or moderate for most tests. Given that mode of test administration, learning effects and technical difficulties explained relatively little of the low test-retest reliability observed, there may be significant short-term variability in cognitive performance in PD in general, which has important implications for clinical care and research.
Investigation the Effect of Rhamnetin on Mice Injected with Solid and Ehrlich Ascites Tumor
Authors: Bozkurt Özlem , Yılmaz Seher , Alpa Şerife , Nisari Mehtap , Yay Arzu Hanım , Ertekin Tolga , Tokpınar Adem , Al Özge , Bozkurt Ali , Kökbaş Umut , Alkan Işınsu , Unur Erdoğan
Published: February 2023

Background and aim: Rhamnetin is a flavonoid which contained in especially clove, such as apple, tea, onion plant. Rhamnetin has been used in cancer research due to its antitumor and antioxidant properties. In this study, effects of rhamnetin administration at different doses on ascites and solid tumors were investigated in Balb/C mice bearing EAT model that originating from rat breast adenocarcinoma.
Experimental procedure: Overall, 92 Balb-c mice were used in this study. EAT cells (1x10⁶cells) that harvested from stock animals were injected to all rats via intraperitoneal and subcutaneous route. Rhamnetin (100µg/kg-200µg/kg) were given intraperitonealy and subcutaneously during 10 and 15 days to the animals bearing ascites tumor and solid tumor respectively. Throughout experiments, weight changes were recorded in all groups. The maximum weight increase was observed in the control group among all groups (ascites and solid tumor groups). In the treatment groups, the least weight increase were determined in 200 µg/kg rhamnetin applied. The lowest increase in tumor volume was observed in the group that received 200µg/kg rhamnetin(2.84) when compared to tumor control group(3.67).
Result and conclusion: We determined that the number of live and dead cells in the treatment groups administered with the mean rhamnetin dose(2.5 µg/ml) was found in the count made in the EAT cell line after the incubation periods. We observed that rhamnetin plays an important role against cancer formation. We have obtained important results in our study, but detailed studies on the relationship between rhamnetin and cancer are needed
Finite time adaptive neural intermittent control for a class of nonlinear dynamical systems
Authors: Wang Weifeng , Hu Junhao , Mei Jun , Wang Sixin
Published: February 2023

In this paper, the semiglobal practical finite-time stable (SGPFTS) problem for a class of nonlinear nonstrict feedback systems is investigated by adaptive neural networks (NNs) intermittent control strategy. This work is motivated by that available differential inequalities to cope with intermittent control do not work for nonstrict feedback nonlinear system (NFNS), since the system dynamics is unknown. In order to deal with this problem, a novel differential inequality and adaptive neural intermittent control are established to handle intermittent control, which generalizes previous works. Then, based on this lemma with the proposed adaptive NNs intermittent control scheme, backstepping design process, finite-time technique and Lyapunov stability theory, sufficient conditions are presented to guarantee the achievement of SGPFTS for NFNS. Furthermore, a networked-based one-link arm dynamics system is applied to the theoretical results. Finally, corresponding simulation results are given to illustrate the effectiveness of the theoretical results and the practicability of the proposed control method.
Developing a group urban tourism recommendation system based on the modified k-means algorithm and fuzzy best-worst method
Authors: samani najmeh , Aliyari Somayeh , Jelokhani Mohammadreza
Published: February 2023

Group recommendation is among the major concerns in urban tour guiding systems. The main challenge is the uncertainty of users’ opinions in conjunction with their preferences, which ultimately leads to the recommendation of unsuitable locations. As the number of unsuitable points of interest (POIs) for each person (tourist) increases, the efficiency of the tour guiding system faces a major decline. This paper seeks to model the uncertainty of urban tourists’ opinions regarding POIs by introducing a two-stage approach called ‘first-clustering, second recommending. The main contributions are the clustering of users based on their attributes via a modified k-means algorithm and the management of opinions using the fuzzy best-worst method (F-BWM). The proposed method is programmed for mobile applications under the name ‘G-tourism’. 485 different users registered in the mobile application and completed all the application wizard pages and 12 tours have been recognized. For each group, the POIs have been weighted, ranked, and recommended according to their members' pairwise comparisons based on BMW and F-BWM. The obtained results have been evaluated based on precision, recall, F-score measures, and user satisfaction. The accuracy assessment of running F-BWM at the second step indicates the higher accuracy of the system and user satisfaction rather than BWM.
Economic and ecological constraints on sheep management in the Algerian steppe
Authors: HARKAT Sahraoui , LAOUN Abbas , BELABDI Ibrahim , YABRIR Benalia , LAFRI Mohamed
Published: February 2023

An 11-year survey conducted in the wilayas of Djelfa, Msila and Biskra reveals two contrasting flock management strategies adopted by Ouled Djellal sheep breeders, shaped by ecological as well as economic factors. Breeders in Djelfa raise an average of 12 ewes per ram, while those in Msila and Biskra raise an average of 28 ewes per ram. This has led to a higher production of lambs/ewe/year in Djelfa than in the other two wilayas. To understand the significance of these strategies, two hypotheses were tested. According to ecology, we expected that in Djelfa, pasture productivity was higher than in the Biskra and M’sila, as a result of higher annual rainfall and hence pluviothermic coefficient Q3. We compared the altitudinal distribution of two stocking rates to pluviothermic coefficients. The ecological view was supported by higher Q3 in Djelfa than in Biskra and M’sila for higher stocking rates. However, the overall degradation of the steppe was, also, more pronounced in Djelfa than in the other two wilayas. In addition, GLM models have shown the impact of climatic parameters on the survival of lambs and adults. From an economic point of view, the higher lamb/ewe production in Djelfa is underpinned by increased marketing facilities, with: i) a strong demand for sheep by the inhabitants of the North, ii) a favorable geographical location, as Djelfa is crossed by the main roads of Algeria linking the South and the capital located in the North, and iii) the presence of the main sheep markets of the country. This study highlights the impact of environmental variables on the management practices of livestock farmers, and points the way for further studies of this type, which are essential as practices will have to adapt to climate change.
Is automatic cephalometric software using artificial intelligence better than orthodontist expert in landmark identification
Authors: Ye Huayu , Cheng Zixuan , Ungvijanpunya Nicha , Chen Wenjing , Gou Yongchao , Li Cao
Published: February 2023

Background: To evaluate the techniques used for automatic digitization of cephalograms, highlighting the strengths and weaknesses of each one and review the percentage of success in localising each cephalometric point.、
Methods: Lateral cephalograms were digitized and traced by three calibrated senior orthodontic residents with or without artificial intelligence (AI) assistance. The same radiographs of 43 patients were uploaded to AI-based machine learning program MyOrthoX, Angelalign and Digident. Image J was used to extract x- and y-coordinates for 32 cephalometric points: 11 soft tissue landmarks and 21 hard tissue landmarks. The mean radical errors (MRE) were assessed radical to the threshold of 1.0mm,1.5mm, and 2 mm to compare the successful detection rate (SDR). One-way ANOVA analysis at significance level of P < .05 was used to compare MRE and SDR. The SPSS (IBM-vs. 27.0) and PRISM (GraphPad-vs.8.0.2) software were used for the data analysis.
Results: Experimental results showed that three methods were able to achieve detection rates greater than 85% using the 2 mm precision threshold, which is the acceptable range in clinical practice. The Angelalign group even achieved a detection rate greater than 78.08% using the 1.0 mm threshold. A marked difference of time was found between the AI-assisted group and the manual group due to heterogeneity in the performance of techniques to detect the same landmark.
Conclusions: AI assistance may increase efficiency without compromising accuracy with cephalometric tracings in routine clinical practice and in research settings.
Increase in Cape Verde hurricanes during Atlantic Niño
Authors: Kim Dongmin , Lee Sang-Ki , Lopez Hosmay , Foltz Gregory , Wen Caihong , West Robert , Dunion Jason
Published: February 2023

At seasonal-to-interannual timescales, Atlantic hurricane activity is greatly modulated by El Niño - Southern Oscillation and Atlantic Meridional Mode. However, they develop predominantly in boreal winter or spring, and are relatively weaker during the Atlantic hurricane season. The leading mode of tropical Atlantic sea surface temperature (SST) variability during the Atlantic hurricane season is Atlantic Niño/Niña, which is characterized by warm/cold SST anomalies in the eastern equatorial Atlantic. However, the linkage between Atlantic Niño/Niña and hurricane activity has not been examined. Here, we use observations to show that Atlantic Niño, by strengthening the Atlantic inter-tropical convergence zone, enhances African easterly wave activity and low-level cyclonic vorticity across the deep tropical eastern North Atlantic. We show that such conditions increase the likelihood of powerful hurricanes developing in the deep tropics near the Cape Verde islands, elevating the risk of major hurricanes impacting the Caribbean islands and the U.S.
Low prevalence of ideal levels in cardiovascular behavior metrics among Mexican adolescents
Authors: Terminel-Zaragoza Ricardo , Angulo-Urías Mariana , Toledo-Domínguez Iván de Jesús , Quintero-Portillo Hebert , Bojórquez-Díaz Cecilia Ivonne , Ulloa-Mercado Gabriela , Gortares-Moroyoqui Pablo , Arias-Gastélum Mayra , Legarreta-Muela Fátima , Renteria-Mexia Ana
Published: February 2023

Background
Unhealthy behaviors are associated with high cardiovascular disease risk. The study aimed to assess the cardiovascular behavioral metrics according to the AHA, in Northwest Mexican adolescents.
Methods
The study was cross-sectional. Demographics, health history, and smoking data were collected by questionnaires. Dietary intakes were estimated using a FFQ, and physical activity using the IPAQ. Measurements included blood pressure and anthropometrics.
Results
Participants were freshmen students (n = 228, 55.6% men, age = 18.5±0.4 y). A higher significant prevalence of men indicated working, playing sports, and having a family history of hypertriglyceridemia (p < 0.05). Men showed significantly higher weight, height, BMI, waist, blood pressure, and lower total physical activity and body fat (p < 0.05). In dietary intakes, significant differences by sex were observed in nuts and seeds (1.1±0.6 and 0.9±0.6 oz/week, p = 0.042) and processed meats (749.8±639 and 503.6± 300.3 g/week, p = 0.002), with only fish and shellfish reaching AHA recommendations (513.1±450.7 and 501.7±428 g/week, p = 0.671), for men and women, respectively. Significant differences in prevalence between ideal, intermediate, and poor levels were shown for systolic (65.2%, 24.8% and 10%, p = 0.001) and diastolic (69.1%, 21.3% and 9.6%, p = 0.01) blood pressure, physical activity (25.9%, 43.9% and 30.3%, p = 0.005), and primary diet score (27.8%, 70.4% and 1.7%, p = 0.022). For individual foods, the lower prevalence in the ideal level was for sugar-sweetened beverages (10%, p = 0.013) and processed meats (4.8%, p = 0.208).
Conclusions
Northwest Mexican adolescents represent a high-risk group for developing long-term unhealthy habits. Their diet and physical activities make them vulnerable to cardiovascular complications early in adulthood.