bluuebunny/crossref_metadata_2025 huggingface dataset:
The multifaceted impact of missing teeth on general health: A narrative review
Authors: Kramarczyk Karolina , Skowron Kamil , Skowron Paweł , Kaczmarzyk Tomasz
Published: September 2024

Tooth loss extends beyond oral health concerns, impacting overall well-being and quality of life. It is a global issue, with approximately 7% of individuals aged 20 years or older affected. Research reveals associations between tooth loss and cardiovascular diseases, including hypertension, atherosclerosis, and peripheral arterial disease, attributed mainly to chronic inflammation and altered dietary habits. However, tooth loss has also been associated with cognitive decline, depression, and certain cancers, including lung, head and neck, pancreatic, and esophageal, suggesting the involvement of complex pathophysiological mechanisms that are increasingly the subject of experimental research. In addition, there are psychosocial consequences, such as self-esteem issues and social discomfort. Therefore, it is indisputable that comprehensive oral care is of utmost importance. Recognizing the importance of oral health for overall well-being highlights the necessity for preventative measures and enhanced dental care. As the global population ages, it is increasingly important to comprehend and address the systemic effects of tooth loss. This review aims to summarize the complex pathomechanisms underlying tooth loss and emphasize the need for a comprehensive approach to address its diverse consequences. It advocates for preventive oral health measures to sustain general health and well-being.
Clinical patterns and treatment outcomes of polycystic ovarian syndrome
Authors: Alawdi Shawqi H. , Alhalabi Marwan , Al-Hallak Rana
Published: September 2024

Background: Polycystic ovary syndrome (PCOS) is a common chronic endocrine disorder in women with complex and poorly understood etiologies. The present study aimed to describe the clinical features of PCOS in a sample of Syrian women as well as the risk factors, associated comorbid diseases, and patterns and efficacy of treatment. Methods: The present study is cross-sectional observational study conducted on a sample of Syrian women diagnosed with PCOS, using self-administered questionnaire during the period between December 25, 2023 and January 18, 2024. Overall, 1666 women with PCOS were recruited through online platforms. Results: Higher frequency of PCOS was observed in young women aged 15–25 years (63.1%) and in single ladies (76.5%). The main chief complaints experienced by patients with PCOS were hirsutism (71.25%), irregular menstrual cycle (70.95%), depressed mood (53.9%), acne (49.52%), abdominal obesity (43.88%), alopecia (38.12%), and weight gain (34.57%). The most common risk factors observed in patients with PCOS were lack of physical exercise (76.4%), unhealthy food habits (51.6%), family history (38.5%), and history of taking anabolic steroids (17.2%). Comorbid diseases were found in 11.5% of PCOS patients. These diseases were hypothyroidism (5.7%), hypertension (3.06%), dyslipidemia (1.68%), heart diseases (1.56%), and diabetes mellitus (0.78%). Most patients were treated with oral contraceptive pills (82.11%) or metformin (64.83%). The efficacy of treatment was observed as complete cure in 430 patients (25.8%) and partial response alleviating symptoms in 819 patients (49.2%), while and no benefit was found in 417 patients (25%). Conclusions: PCOS is associated with widespread dermatological and metabolic aberrations that pose psychological burden on women and increase their risk for having comorbid diseases. Most patients with PCOS do not receive adequate therapy. Understanding the risk factors and clinical features for each patient is essential to choose the proper treatment.
Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on large farms?
Authors: Ekinci G. , Deniz O. , Tüfekci E. , Timur M.C. , Onmaz A.C. , Günes V. , Citil M. , Keles İ. , Hoven R.V.D.
Published: September 2024

Rhodococcus equi (R. equi) is a primary cause of pyogranulomatous pneumonia of foals between three weeks and five months of age. Early diagnosis of rhodococcal pneumonia has always been considered a preferable approach as it can lead to more successful treatment and better outcomes. Horse stud farms where the disease is common, neonatal foals are subjected to tests such as complete blood count and fibrinogen analysis at certain intervals. However, new biomarkers are needed in addition to blood count and fibrinogen measurement in this field for early diagnosis of diseases. Based on this need, in this study, the diagnostic importance of CL-11, SP-A, SP-D was investigated for the early diagnosis of pneumonia in foals naturally infected with R. equi. In a case-control design, fourteen 1-5 month-old foals with proven R. equi pyogranulomatous pneumonia and 10 healthy 1-5 month-old control foals were enrolled in this study. The median white blood cell count (WBC) and fibrinogen concentration in the case group were significantly higher than in the control group. The median CL-11, SP-A, and SP-D concentrations in the case group were also significantly higher than in the control group. However, there were overlaps in concentrations between groups for SP-A and SP-D. There was less overlap between the groups for the CL-11 concentration. The CL-11 assay was sufficiently accurate but over-diagnosed R. equi infection. The correlation plot between fibrinogen and CL-11 concentrations shows that this problem may be solved if CL-11 is used as the first biomarker and fibrinogen as the second check for those foals with CL-11 serum levels >0.8 and ≤1.5 ng/mL. As a result, in this study, it is recommended to use CL-11 together with fibrinogen to obtain more accurate results in diagnosing pyogranulomatous pneumonia caused by R. equi in foals on large horse stud farms.
Molecular detection and subtype distribution of Blastocystis sp. from shelter dogs and cats in Van, Turkey: First report of ST10 in cats and ST1, ST10 and ST30 in dogs
Authors: Ayan A. , Aslan Çelik B. , Çelik Ö.Y. , Yılmaz A.B. , Orunç Kılınç Ö. , Oktay Ayan Ö.
Published: September 2024

Blastocystis is an intestinal protist commonly found in humans and many different animal species. It is probably the most common enteric parasite with an estimated one billion infections worldwide. The fecal materials for this study were collected from 100 cats and 200 dogs different age and sex in shelter in Van, Turkey. DNA extraction, PCR amplification and sequence analysis were performed on the fecal samples. As a result, a prevalence of 1% (1/100) in cats and 1.5% (3/200) in dogs was detected. The prevalence was higher in both cats and dogs, in age groups younger than one year and in females according to gender. Sequence analysis revealed Blastocystis sp. ST10 in cats and Blastocystis sp. ST1, ST10 and ST30 in dogs. The sequences obtained were deposited in Genbank. In conclusion, stray cats and dogs may be a source of infection for other cats and dogs, and the detection of zoonotic ST1 in dogs suggests that dogs may be a reservoir for human infection.
Evaluation of susceptibility to pyrazinamide and streptomycin, isoniazid, rifampin and ethambutol of Mycobacterium caprae strains isolated from European bison (Bison bonasus caucasicus) in the Bieszczady Mountains (Southern Poland)
Authors: Didkowska A. , Krajewska-Wędzina M. , Nowakiewicz A. , Orłowska B. , Bochniarz M. , Kozińska M. , Wójcik W. , Weiner M. , Anusz K.
Published: September 2024

The material for drug resistance testing was 28 strains of Mycobacterium caprae isolated from tissue collected post mortem from a free-living Bieszczady Mountain European bison (Bison bonasus caucasicus) herd. All drug susceptibility tests were carried out on an automated Bactec mycobacterial growth indicator tube (MGIT) 960 system, using Bactec MGIT 960 streptomycin, isoniazid, rifampin and ethambutol (S.I.R.E.) and Bactec MGIT 960 PZA kits. The analyzed M. caprae strains demonstrated susceptibility to PZA and the complement of four basic anti-mycobacterial drugs: S.I.R.E. Considering that we are dealing with multidrug-resistant and extremely drug-resistant tuberculosis more and more often, and that no new drugs have been discovered or developed for over 60 years, the study of drug resistance in free-living animal strains of MTBC is of great importance for the deepening and broadening of our knowledge of TB.
Whole exome sequencing in relapsed or refractory childhood cancer: case series
Authors: Thangpong Rungroj , Nuwongsri Pattarin , Ittiwut Chupong , Ittiwut Rungnapa , Phokaew Chureerat , Techavichit Piti , Suphapeetiporn Kanya
Published: September 2024

Background

The prognosis for relapsed or refractory childhood cancer is approximately 20%. Genetic alterations are one of the significant contributing factors to the prognosis of patients.

Objective

To investigate the molecular profile of relapsed or refractory childhood cancers in Thai cases.

Methods

The study design is a descriptive study of patients <18 years old, suspected or diagnosed of relapsed or refractory childhood cancer who underwent whole exome sequencing (WES).

Results

WES was successfully performed in both the tumor and the blood or saliva samples obtained from 4 unrelated patients. Six different variants were identified in the NCOR2, COL6A3, TP53, and SMAD4 genes. These alterations were found to be associated with tumor aggressiveness.

Conclusion

This study is the first one to demonstrate genetic alterations by using WES in relapsed or refractory childhood cancer in Thai cases.
Investigating the Formation Phase of a New Online Social Network
Authors: Brînduşescu Alin
Published: September 2024

Over the last decade, we have witnessed the emergence of numerous online social media platforms and a growing research interest in understanding their underlying structures and mechanisms. This paper investigates the formation and evolution of the EcoNation social media platform, which is designed to foster collaboration for environmental sustainability.

The network structure of EcoNation is introduced and analyzed using a comprehensive dataset covering the platform’s initial years of development. This analysis is conducted using the social network analysis toolbox, which enables the exploration of various aspects of user interactions, connectivity, and engagement patterns. By delving into the data, the aim is to uncover the dynamics that drive the growth and development of EcoNation’s network.

The dataset includes information on user registrations, actions performed, validations, and connections formed over time. By examining this data, key trends and behaviors that have shaped the platform’s evolution can be identified. To facilitate further research and enable other scholars to build on this paper’s findings, the exported data was made publicly available.
Development of a patient-reported outcomes tool to monitor changes in joint health and wellbeing for young people with haemophilia B
Authors: Bladen Melanie , McDonagh Janet , McLaughlin Paul , Gooding Richard , Holder Kerry-Ann , Thind Sharon , Klooster Brittany , Shields Alan , Turner-Bowker Diane M. , Chatterton Kaitlin , Leso Allison , Volpi Connor , Sivasubramaniyam Sujan , Abulizi Jiawula , Khan Nisa
Published: September 2024

Introduction

Early detection of joint bleeds is challenging yet critical for preserving joint health among individuals with haemophilia. This work explored early indicators of joint bleeds and young people with haemophilia B (YPwHB) self-monitoring practices to develop a joint health patient-reported outcome (PRO) tool for YPwHB aged between 8-25 years.

Methods

A targeted concept-focused literature review, an advisory panel of haemophilia care providers (n=8), followed by a focus group of YPwHB (n=5, 10–21 years), caregivers (n=5), and haemophilia specialists (n=1 physiotherapist; n=1 psychologist) were consulted to gain insights on joint bleed experience and monitoring of YPwHB. Qualitative data were analysed, and outputs were used to develop a preliminary PRO tool.

Results

The literature review identified joint bleed symptoms, including preferred position of the joint, skin discolouration, pain, and swelling. Impacts specific to joint bleeds include inability to load the joint, limited mobility, and restricted range of motion. Advisory board panellists expressed the value of a PRO tool that explores physical symptoms and well-being and facilitates a shared language between YPwHB, caregivers, and healthcare professionals while also improving body confidence and body awareness in YPwHB. Focus group participants reported symptoms of joint bleeds as ‘different than normal’, ‘deep’ pain, tingling, stiffness, and inability to bend the joint. Impacts on daily life included emotional aspects, sleep, and interference with daily activities. Participants reported a need to increase knowledge of joint bleed symptoms and how to distinguish from other symptoms.

Conclusion

A PRO tool could support YPwHB and their caregivers, increase awareness of joint health, and support conversations among YPwHB, caregivers and healthcare providers. A feasibility study is planned for the PRO tool. Use of the PRO tool may be of clinical relevance to other inherited bleeding disorders.

Patient or Public Contribution

YPwHB and their caregivers participated in an independent focus group to share their experience of joint bleeds, and how they detect and track joint bleeds, and to provide their view on a self-monitoring tool to monitor joint health. This informed the language used in the PRO tool questions developed for the feasibility study but is not presented in this publication.
Self-mediatisation and the format of Swedish parliamentary speeches: Speech length and political slogans, 1920–2019
Authors: Jarlbrink Johan , Norén Fredrik Mohammadi
Published: September 2024

In this article, we investigate traces of a news media logic in the Swedish parliamentary speeches from 1920 to 2019. Drawing on theories of mediatisation, we examine two aspects: the length of the speeches and repeated political slogans. Our analysis is based on a complete corpus of parliamentary records with annotated speeches. Speech length was measured based on word count, and the identification of slogans was based on repeated seven-word segments, filtered to exclude generic phrases. While it is difficult to draw any definitive conclusions about the influence of an external media logic, the speech length has dropped by 50 per cent since 1920. This change relates to new parliamentary procedures, and from the 1980s, with the explicit goal to attract the news media. Short and snappy political slogans have increased significantly since the 1990s. This development reflects previous research stating that sound bites are getting shorter.
Domino Antimagic Squares and Rectangles
Authors: Marr Alison M. , Napier Christina , Nelsen Lauren M. , Nelsen Luke L. , Vasilevska Violeta
Published: September 2024

A domino antimagic square of order n is an n×n array formed from a subset of the standard set of 28 dominoes such that the sums of the rows, columns, and two main diagonals form a set of 2n + 2 distinct, consecutive integers while an m × n domino antimagic rectangle is an m × n rectangular array formed from a subset of the standard set of 28 dominoes such that the sums of the rows and columns form a set of m + n distinct, consecutive integers. This paper outlines what the possible dimensions are for m×n domino antimagic rectangles and provides many examples of both domino antimagic rectangles and squares. Many open questions are given at the end of the paper for future exploration.
Numbers Without Ones (Revisited)
Authors: Kuhn Steven T.
Published: September 2024

We discuss some open problems about occurrences of the digit one.
Sensory Analysis of Chocolate Cakes Enriched with Fish Protein Hydrolyzate (HPP)
Authors: Rossetto Janaina Fernanda , Wenzel Andréia , Viana Mayara Cristina Marcondes , Rocha Joana D’Arc Maurício , Vogel Lucas Fabricio , Signor Altevir
Published: September 2024

Objective: The objective of this study is to investigate the acceptance of chocolate cake enriched with fish protein as a way of adding nutritional quality to everyday consumer products.
 
Theoretical Framework: Fish protein hydrolysate is obtained by breaking the peptide bonds between proteins, through enzymatic or chemical action. Through these processes, the amino acids decrease in size and are better used in foods, as they are a source of nutrients of excellent nutritional quality.
 
Method: The methodology adopted for this research involves fish protein hydrolysate (FHP) made from tilapia filleting trimmings, as a protein source for chocolate cake formulations, replacing wheat flour. FHP was added in liquid (FHPPL) and dehydrated (FHPPD) forms, both with 2% inclusion in the formulations. After preparation, the cakes were sensorially evaluated by 30 untrained tasters, using the affective sensory method through acceptance and purchase intention tests with a hedonic scale. The data obtained were subjected to analysis of variance (ANOVA) and Tukey's test to compare the means at 5% significance.
 
Results and Discussion: The results obtained revealed that there were no differences (p<0.05) between the formulations in the acceptance test, although in the purchase intention test the control formulation showed a difference (p<0.05) compared to the formulation with HPPL. On the other hand, the acceptability test demonstrated that the products prepared have good acceptance with values ​​above 70% (85.8; 80.8 and 80.11, respectively).
 
Research Implications: Chocolate cakes enriched with fish protein sources are an excellent alternative for human nutrition, as they represent an excellent nutritional source for people who are concerned about healthy foods. There are several studies using animal protein sources such as fish to prepare healthy and easy-to-prepare foods, since people's fast-paced routines nowadays require quick and healthy foods.
 
Originality/value: this study contributes to the literature by highlighting the supplementation of foods with processed fish by-products and enhanced in the form of protein hydrolysates.
El caracol y la flecha
Authors: Matallana Peláez Susana Eugenia
Published: September 2024

Partiendo de dos textos escritos por pensadores indíge­nas colombianos, El caracol y la flecha reconstruye en un primer momento lo que significó para Abya Yala, a partir de la Conquista, la imposición de una tempora­lidad lineal y de una ontología no-relacional, totalmente ajenas a la arquitectura conceptual del continente hasta la llegada de los europeos. Posteriormente, en un segundo momento, el texto pasa a examinar en qué consisten exacta­mente la temporalidad espiralada y la ontología relacional que predominaban en la Abya Yala prehispánica, para luego pasar a considerar las posibilidades conceptuales y de libera­ción y emancipación que dicha temporalidad y ontología albergan para nuestro continente.
ELABORAÇÃO DE MORTADELA DE CMS DE CODORNAS POEDEIRAS DE DESCARTE ENRIQUECIDAS COM PÓ DE CASCA DE OVOS
Authors: Oliveira Gislaine Gonçalves , Coradini Melina Franco , Maia Karina Milene , Barbosa Marcos Adriano Pereira , Marciano Luany Emanuella Araujo , Gasparino Eliane , De Souza Maria Luiza Rodrigues , Marcato Simara Marcia
Published: September 2024

O objetivo do trabalho foi desenvolver mortadela de carne mecanicamente separada (CMS) de codornas poedeiras (Coturnix japonica) de descartes enriquecida com diferentes níveis de pó de casca de ovo e avaliar os aspectos físicos, químicos, microbiológicos, sensoriais, juntamente com a aceitação e intenção de compra. Produziu-se quatro produtos, com diferentes níveis de inclusão de pó de casca de ovos sendo eles: tratamento 1 = mortadela controle, com 0%; tratamento 2 = mortadela com adição de 2%; tratamento 3 = mortadela com adição de 4% e tratamento 4 = mortadela com adição de 6% de pó de casca de ovo. Os produtos foram submetidos as análises microbiológicas, composição química, pH e sensorial. Os resultados foram satisfatórios, visto que todos os tratamentos estavam aptos ao consumo humano. A inclusão de pó de casca de ovo aumentou o teor de umidade, porém quando adicionado 2%, o produto apresentou melhor aceitação e menor valor calórico. Conclui-se que adicionando o pó de casca de ovo em mortadelas elaboradas com CMS de codornas de poedeiras de descarte ocorreu redução do valor calórico, apresentando melhor qualidade nutricional e aceitação para os atributos avaliados quando incluído 2% de pó de casca de ovo, levando o produto a possibilidade de comercialização, assim como, se tornando uma excelente alternativa de alimento.
Hubungan Tingkat Aktivitas Fisik terhadap Tingkat Kecemasan Mahasiswa Fakultas Teknik selama Pandemi COVID-19
Authors: Irwan Sirande Ludwieg Angelo , Irene Irene , Mahaputra Mahaputra , Suryani Eva
Published: September 2024

Pendahuluan: Aktivitas fisik diketahui dapat menjadi salah satu metode untuk menjaga kesehatan mental seseorang. Namun, munculnya pandemi COVID-19 menyebabkan berkurangnya frekuensi aktivitas fisik seseorang. Banyak literatur yang telah membahas mengenai hubungan aktivitas fisik terhadap gangguan cemas, namun penelitian tersebut belum pernah dilakukan pada mahasiswa fakultas teknik di Indonesia.
Metode: Penelitian ini  merupakan studi cross sectional dengan jumlah sampel 101 mahasiswa Fakultas Teknik Unika Atma Jaya angkatan 2018-2020. Alat ukur yang digunakan adalah International Physical Activity Questionnaire (IPAQ) long form Bahasa Indonesia dan kuesioner Generalized Anxiety Disorder 7-item (GAD-7). Analisis data menggunakan metode Kruskall Wallis dengan analisis post-hoc Dunn-Bonferroni dan uji korelasi Spearman.
Hasil: Sebanyak 46 mahasiswa (45,55%) mencapai tingkat aktivitas fisik sedang dan sebanyak 41 orang (40,59%) tidak mengalami gangguan cemas. Ditemukan hubungan yang signifikan antara tingkat aktivitas fisik dengan tingkat gangguan cemas (p-value = 0,004). Ditemukan korelasi negatif yang signifikan pada tingkat aktivitas fisik dan tingkat gangguan cemas (p-value = 0,033; r = -0,213)
Kesimpulan: Terdapat hubungan yang bermakna antara tingkat aktivitas fisik dengan tingkat gangguan cemas pada mahasiswa Fakultas Teknik Unka Atma Jaya angkatan 2018-2020.
Screening for Developmental Coordination Disorder in Elementary School Children Aged 6 – 8 Years During Covid-19 Pandemic in Cirebon City: A Comparative Study with Stunted and Normal-Height Children
Authors: Gunawan Kevin , Elvira Junita , Hadiyanto Hadiyanto , Surjono Edward
Published: September 2024

Introduction: Developmental coordination disorder (DCD) is a neurodevelopmental disorder in children characterized by deficit in gross and fine motor skills. The majority of stunted children often experience various neurodevelopmental problems. In Indonesia, there are limited studies about DCD, specifically in stunted and normal-height children. This research aims to describe DCD in stunted children and its comparison with normal-height children.
Methods: A cross-sectional study of 172 elementary school children in Cirebon City. Sampling was done by consecutive sampling method. DCDQ 2007 and DCDDaily-Q was used to determine DCD in children and had been validated in Indonesian. Statistical analysis is conducted using IBM SPSS Ver 22.
Results: The proportion of DCD based on DCDQ 2007 and DCDDaily-Q was 11.0%. The incidence of DCD in stunted children was found to be higher than in normal-height children (14.1% vs 8.9%). Analysis test showed that there was a significant difference between the two groups in the mean quality score of the performance (p = 0.040) and learning activity daily living (ADL) (p = 0.035) on subjects with DCD,
Conclusion: DCD were more commonly found in stunted children, especially deficits in performance and learning ADL. Early detection for children's motor development is very necessary, especially during the Covid-19 pandemic.
TEKNIK PENGOPERASIAN ALAT TANGKAP BOUKE AMI PADA KM SINAR SAMUDERA TERHADAP HASIL TANGKAPAN DI PERAIRAN SELAT KARIMATA
Authors: Heri Kuswoyo Agus , Fatoni Fatoni , Wulandari Ully , Sitepu Mestiria harbani
Published: September 2024

Penelitian ini bertujuan untuk mengetahui teknik pengoperasian alat tangkap bouke ami serta hasil tangkapan yang dioperasikan di perairan selat karimata. Penelitian dilaksanakan selama dua bulan yaitu dari bulan Maret hingga bulan Mei 2023 di Pelabuhan Perikanan Samudera Nizam Zachman Jakarta dengan mengikuti kapal yang beroperasi di perairan selat karimata dengan metode observasi langsung. Analisis data menggunakan deskriptif dan analisis komposisi hasil tangkapan. Hasil pengamatan pada pengoperasian alat tangkap bouke ami yaitu terdapat tahapan persiapan, setting dan hauling. Alat tangkap yang digunakan memiliki panjang 18 meter dan lebar atau diameter jaring 16 meter dengan mesh size yang berbeda. Pada kaki jaring memiliki mesh size 5 cm terbuat dari bahan PE, badan jaring dengan mesh size 2 cm dan kantong jaring 1,5 cm. Hasil tangkapan didominasi cumi-cumi (loligo sp) sebanyak 255 kg, semampar (Pharaoh cuttle fish) sebanyak 25 kg dan blakutak (Squid sepiela) sebanyak 12 kg dengan nilai komposisi jenis terbesar pada jenis Loligo sp Sebesar 80% kemudian Pharaoh cuttle fish Sebesar 8 % diikuti Squid Sepiela sebesar 4 % dengan by-catch sebesar 8%.
Immunization Status, Immunization Coverage, and Factors Associated with Immunization Service Utilization Among HIV-Exposed and HIV-Infected Children in India
Authors: Datta Mousumi , Yasmin Shamima , Biswas Rahul
Published: September 2024

Background and Objective

HIV-infected and HIV-exposed children are known to have a lower immunization coverage. However, the current immunization coverage for this group of children in India is unknown. The present study assessed the immunization status, service-utilization issues, and factors associated with immunization status among them.

Methods

A descriptive, cross-sectional, and multisite study was conducted in four districts (Nadia, Murshidabad, South and North 24 Parganas) of West Bengal, a state in the Eastern part of India. Children aged between 12 and 59 months were included in the study. A sample size of 131 was calculated using Cochrane’s formula. Onsite data was collected using an interviewer-administered predesigned, pre-tested, face-validated, semi-structured schedule. Immunization status was the outcome variable. The unadjusted association of the outcome variable with other variables was tested by the Chi-square test and the adjusted association was tested by regression analysis.

Results

The mean age of the children was 35.5 months (±15.7) and 50.4% were male. There were 18 (13.7%) HIV-infected children. Eighty-four percent of children were adequately immunized, but when considered along with the birth dose of the Hepatitis-B (Hep-B) vaccine, this reduced to 58.8%. Murshidabad district had the lowest proportion of fully immunized children (50%), while South 24 Parganas district had the lowest proportion of completely immunized children (60%). More than 95% of vaccinations were done in government facilities. Service utilization issues identified were lack of awareness of vaccine due dates and facing stigma from providers. Immunization status was associated with experience of stigma, mode and place of delivery by Chi-square test, it was only associated with stigma by regression analysis.

Conclusion and Global Health Implications

Relatively lower immunization coverage among children born of HIV-infected women can be attributed to parents’ unawareness about vaccination due dates and facing stigma while accessing service. Measures like documenting vaccine due dates and training healthcare providers on non-discriminatory, respectful care may improve vaccination coverage.
Prevalence of temporomandibular joint disorders and its association with stress among dental students in Davangere city – A cross-sectional survey
Authors: Chinthalapalli Sai Teja , Sapna B. , Gujjar Vittoba Rao Pramod , Sulthana D. S. Gazala , Chalamala Naga Sai Sahithi , Neha N. C. , Smitha G. P. , Kavya M. K.
Published: September 2024

Objectives:

Dental students are exposed to some complex experiences that predominantly lead to stressful situations and expose them to temporomandibular disorders (TMDs).Aim: The aim of this study was to determine the prevalence of TMD and how it relates to stress among dental students.Study Setting and Design: A cross-sectional survey was carried out among 283 undergraduate dental students, who consented to participate across all academic levels.

Material and Methods:

TMD was evaluated using the Diagnostic Criteria for TMDs Axis-I and Axis-II methodology. In Axis-I, screening and clinical examinations of TMD, and in Axis-II, stress as one of the psychosocial risk factors of TMD is evaluated using the modified dental environment stress scale (DESS).

Results:

The overall prevalence of TMD was 61.2 %. Headache followed by clicking, pain on clicking, difficulty in mouth opening, and jaw locks were the most commonly reported symptoms. On clinical examination, clicking was the most common TMD sign, followed by temporomandibular joint pain. Among the various TMDs, the most prevalent TMD was disc displacement followed by myofascial pain dysfunction syndrome. Females were slightly more affected by TMDs than males. TMDs were more common among the final year dental students followed by interns (house surgeons). Further, participants with TMD symptoms and signs had significantly higher mean DESS scores than others.

Conclusion:

It has been demonstrated that dental students, particularly those enrolled in clinical programs, have a higher chance of acquiring TMDs, which has been strongly linked to elevated levels of stress.
Surgical pearl: Use of micropore tape for easy harvestation and transfer of suction blister epidermal graft
Authors: Mukhtar Muhammed
Published: September 2024

Epidermal graft produced by suction is useful in treating vitiligo. However, it is very difficult to handle thin, flimsy, and translucent epidermis due to its in-curling and wrinkling properties. This is due to the hemispherical blister roof surface area which is twice its circular base. The correction of the epidermal surface and its resizing is a cumbersome and time-consuming task during epidermal grafting. To combat these problems, the blister roof is patched with micropore adhesive tape as a novel technique for harvestation and transfer of the suction blister graft.
Cerebellopontine angle craniopharyngioma in familial adenomatous polyposis
Authors: Bose Sayantan , Balogun James , du Plessis Daniel , Bailey Matthew , Lalloo Fiona , Pathmanaban Omar
Published: September 2024

Background:

Craniopharyngiomas are benign tumors arising in the sellar and suprasellar regions. Although ectopic tumors do occur, it is usually due to local spread or recurrent tumors. Purely ectopic cerebellopontine angle (CPA) or 4th ventricle tumors are extremely rare and have been found to be significantly associated with familial adenomatous polyposis (FAP), a genetic disorder.

Case Description:

Only four cases of ectopic CPA craniopharyngioma associated with FAP have been reported to date. Here, we present the 5th case of ectopic CPA craniopharyngioma on a background of FAP. The previously described cases have been elaborated as well.

Conclusion:

CPA tumor with a background of FAP should raise a differential diagnosis of craniopharyngioma, and similarly, a CPA primary ectopic craniopharyngioma may raise suspicion of underlying APC gene mutation.
Venous thromboembolism prophylaxis in operative traumatic brain injury
Authors: Lara-Reyna Jacques , Jagtiani Pemla , Karabacak Mert , Paik Gijong , Legome Eric , Margetis Konstantinos
Published: September 2024

Background:

Venous thromboembolism (VTE) is a significant complication in patients with traumatic brain injury (TBI), but the optimal timing of pharmacological prophylaxis in operative cases remains controversial.

Methods:

This retrospective study aimed to describe the timing of pharmacological prophylaxis initiation in operative TBI cases, stratified by surgery type, and to report the frequency of worsening postoperative intracranial pathology.

Results:

Data from 90 surgical TBI patients were analyzed, revealing that 87.8% received VTE pharmacological prophylaxis at a mean of 85 hours postsurgery. The timing of initiation varied by procedure, with burr holes having the earliest start at a mean of 66 h. Craniotomy and decompressive craniectomy had the longest delay, with means of 116 and 109 h, respectively. Worsening intracranial pathology occurred in 5.6% of patients, with only one case occurring after VTE pharmacological prophylaxis initiation. The overall VTE rate was 3.3%.

Conclusion:

These findings suggest that initiating VTE pharmacological prophylaxis between 3 and 5 days postsurgery may be safe in operative TBI patients, with the timing dependent on the procedure’s invasiveness. The low frequencies of worsening intracranial pathology and VTE support the safety of these proposed timeframes. However, the study’s limitations, including its single-center retrospective nature and lack of a standardized protocol, necessitate further research to confirm these findings and establish evidence-based guidelines for VTE pharmacological prophylaxis in operative TBI patients.
Microvascular decompression for primary trigeminal neuralgia with the 3/4 circumferential expanded polytetrafluoroethylene (ePTFE) sleeve technique
Authors: Burgos-Sosa Erik , Mendizabal-Guerra Rafael , Nieto-Velazquez Nayeli Goreti , Ayala-Arcipreste Arturo
Published: September 2024

Background:

Microvascular decompression (MVD) using Teflon or Ivalon is the surgeon’s preference for treating trigeminal neuralgia (Tn). Still, sometimes the prosthetic material is unavailable, or there is some recurrence of pain during the follow-up. In this case series, we report the outcome analysis for MVD using the expanded polytetrafluoroethylene (ePTFE) sleeve technique in classic Tn.

Methods:

We conducted a retrospective analysis of patients with Tn from January 2017 to March 2022. Classic or primary Tn was considered a direct compression by a cerebrovascular structure in the posterior fossa, detected by magnetic resonance imaging or direct surgical visualization. Pre- and postoperative Barrow Neurological Institute Pain Intensity Scale (BNI-SI) and Barrow Neurological Institute Hypoesthesia Scale (BNI-HS) were used for the clinical results assessment of the ePTFE sleeve circumferential technique.

Results:

There were nine patients approached with the 3/4 circumferential ePTFE sleeve technique with BNISI IV (n: 11, 58%) and BNI-SI V (n: 8, 42%). In all patients, there was a clinical improvement after the surgical treatment (P < 0.001). All patients obtained BNI-SI ≤ IIIa in an average follow-up of 11.89 (±14.137), with a slight improvement in BNI-HS (P: 0.157). In our revision, this technique has not previously been described for Tn.

Conclusion:

The circumferential ePTFE sleeve technique is a good option for MVD in Tn. For classic Tn, MVD could remain the first option, and this technique could be applied for multi-vessel compression.
Collective Information System Use: A Typological Theory
Authors: Negoita Bogdan , Lapointe Liette , Rivard Suzanne
Published: September 2024

As the nature of information systems (IS) has evolved from primarily standalone, to enterprise, and distributed applications, the need for a better understanding of collective IS use has become a research and practical necessity. In view of contributing to this understanding, we conceptually define collective IS use as a unit level construct, rooted in instances of individual-level IS use within the context of a common work process. Its emergence from the individual to the unit level is shaped by different configurations of task, user, and system interdependence between instances of individual-level IS use. On the basis of this definition, we propose a typology of collective IS use that comprises four ideal types, namely siloed use, processual use, coalesced use, and networked use. For each ideal type, we theorize on the emergence process from the individual to the unit level and we consider the measurement implications for each.
The Role of Venture Capital in the Formation of a New Technological Ecosystem: Evidence from the Cloud
Authors: Breznitz Dan , Forman Chris , Wen Wen
Published: September 2024

The diffusion of new information technology (IT) requires the development of an ecosystem of hardware and software producers, users, and other firms. It is widely believed that venture capitalists (VCs) can play a role in the development of such ecosystems. However, empirical research to elaborate on these points is lacking. Focusing on the recent rapid rise of one platform, cloud computing, we assemble a unique dataset to look at the period just before wide acceptance of the cloud. We find evidence of complementarity between VC financing and the introduction of new products offered over the cloud. Moreover, the complementarity effects are significantly stronger for firms backed by VCs that had rich experience in the IT industry and are significantly weaker for firms that had prior experience developing traditional client/server products. These results provide evidence that supports a role for VC financing in the creation of new technological ecosystems.
Meaningful Healthcare Security: Does Meaningful-Use Attestation Improve Information Security Performance?
Authors: Kwon Juhee , Johnson M. Eric
Published: September 2024

Certification mechanisms are often employed to assess and signal difficult-to-observe management practices and foster improvement. In the U.S. healthcare sector, a certification mechanism called meaningful-use attestation was recently adopted as part of an effort to encourage electronic health record (EHR) adoption while also focusing healthcare providers on protecting sensitive healthcare data. This new regime motivated us to examine how meaningful-use attestation influences the occurrence of data breaches. Using a propensity score matching technique combined with a difference-in-differences (DID) approach, our study shows that the impact of meaningful-use attestation is contingent on the nature of data breaches and the time frame. Hospitals that attest to having reached Stage 1 meaningful-use standards observe fewer external breaches in the short term, but do not see continued improvement in the following year. On the other hand, attesting hospitals observe short-term increases in accidental internal breaches but eventually see long-term reductions. We do not find any link between malicious internal breaches and attestation. Our findings offer theoretical and practical insights into the effective design of certification mechanisms.
Herding and Social Media Word-of-Mouth: Evidence from Groupon
Authors: Li Xitong , Wu Lynn
Published: September 2024

Modern online retailing practices provide consumers with new types of real-time information that can potentially increase demand. In particular, showing sales information to a customer can increase certainty about product quality, inducing consumers to herd. This effect can be particularly salient for experience goods due to their quality being inherently highly uncertain. Social media word-of-mouth (WOM) can increase product awareness as product information spreads via social media, increasing demand directly while amplifying existing quality signals such as past sales. This study examines the mechanisms behind the strategy of facilitating herding and the strategy of integrating social media platforms to understand the potential complementarities between the two strategies. We conduct empirical analysis using data from Groupon.com, which sells goods in a fast cycle format of “daily deals.” We find that facilitating herding and integrating social media platforms are complements that generate sales, supporting the idea that it is beneficial to combine the two strategies on social media platforms. Furthermore, we find that herding is more salient for experience goods, consistent with our hypothesized mechanisms, while the effect of social media WOM is similar for experience goods and search goods.
Association of Endotrophin Levels with Metabolic Parameters in Polycystic Ovarian Syndrome (PCOS) Patients
Authors: Singh Mamta , Ramadoss Priyadarshini , Kumar Praveen , Ashok S. Ben
Published: September 2024

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder associated with metabolic dysfunction. This study investigated serum endotrophin levels, a novel adipokine, in PCOS patients and its relationship with metabolic parameters. In this case-control study, 40 women with PCOS and 40 healthy controls were enrolled. Serum endotrophin levels, metabolic parameters and anthropometric measurements were assessed. Women with PCOS had significantly higher serum endotrophin levels compared to controls (7.1 ± 5.6 ng/mL vs 1.9 ± 1.7 ng/mL, p < 0.0001). Endotrophin levels were positively correlated with BMI (r = 0.4120, p = 0.0001), waist-to-hip ratio (r = 0.3857, p = 0.0004) and blood pressure (SBP: r = 0.3275, p = 0.0030; DBP: r = 0.4076, p = 0.0002). No significant correlations were observed between endotrophin and fasting glucose, insulin, or HOMA-IR. ROC curve analysis revealed high diagnostic accuracy of endotrophin for PCOS (AUC = 0.9641, sensitivity 95%, specificity 90%). These findings demonstrated that serum endotrophin levels are elevated in PCOS and correlate with key anthropometric measures, suggesting its potential role in PCOS pathogenesis. The high diagnostic accuracy indicates endotrophin's as a novel biomarker for PCOS. Further metabolomic research could reveal the mechanistic links between endotrophin and PCOS pathophysiology.
New and Old Names on Ceramic Stamps of Chersoneses Taurica and Sinope
Authors: Федосеев Н.Ф.
Published: September 2024

Статья посвящена анализу публикации С. Ю. Внукова и Н. В. Ефремова некоторых новых клейм из раскопок поселения Кара-Тобе в Северо-Западном Крыму. Исправляются ошибки, допущенные авторами, исправляется восстановление легенд клейм. Часть клейм, объявленных авторами как новые, были опубликованы ранее. Опровергается возможность возрождения астиномной магистратуры в Синопе после ее существования. Делается вывод, что необходимо более тщательно готовить материал при подготовке его к публикации.

The paper analyzes S. Yu. Vnukov and N. V. Efremov’s publication of new stamps from the excavations at the Kara-Tobe settlement in Western Crimea. It corrects errors made by the authors and amends the legends restored on the stamps. Some stamps that were declared by the authors as new had been published before. Possible revival of a magistracy of astynomoi in Sinope after it ceased to function is rejected. The paper concludes that the material for publication should be prepared more carefully.
A Back Story on Fragments of Terracotta Slabs Featuring an Elephant Discovered at Novaya Nisa
Authors: Пилипко В.Н.
Published: September 2024

Изучение данного вопроса показало, что эта история длится уже восемь десятков лет. В нее вовлечены три поколения исследователей Новой Нисы – А. А. Марущенко (1936 г.), сотрудники Южно-Туркменистанской археологической комплексной экспедиции (ЮТАКЭ) (1946–1949 гг.) и сотрудники Нисийской экспедиции (2013–2018 гг). В 1949 г. в северо-восточном раскопе Новой Нисы найден фрагмент терракотовой плиты с изображением двух воинов, выглядывающих из-за какого-то крупного прямоугольного объекта. Правильную трактовку данного сюжета еще в начале 50-х гг. XX в. предложила М. И. Вязьмитина, но только недавно рукопись ее статьи была обнаружена в архивах Ташкента. На плите был изображен боевой слон. В заметке также излагаются общие сведения о городище Новая Ниса и история обнаружения рукописи М. И. Вязьмитиной.

This issue has a long history, around eighty years. Three generations of Novaya Nisa researchers – A. A. Marushchenko (1936), members of the YuTAKE (the South Turkmenistan Archaeological Expedition) (1948–1949) and members of the Nisa Expedition (2013–2018) – have been involved in its research. In 1949 a fragment of a terracotta slab featuring two warriors emerging from behind a large rectangular object was found in the northeastern excavation pit at Novaya Nisa. The correct interpretation of this narrative was proposed by M. I. Vyazmitina back in the early 1950s, but her manuscript has not been found in the Tashkent archives until recently. The slab depicts a war elephant. The paper also provides some general information on Novaya Nisa and on how M. I. Vyazmitina’s manuscript was discovered.
THE TOOLKIT OF MEDIEVAL RUSSIA STONE CARVERS
Authors: Медынцева А.А.
Published: September 2024

Статья посвящена атрибуции редких каменных изделий – плещек – своеобразных каменных записных книжек, эквивалента средневековых цер для камнерезов, служивших для записей и рисунков. Они входили в рабочий набор мастеров-камнерезов для обучения и отработки приемов резьбы, рисунков и письма по камню. Материалом для идентификации предметов послужила надпись на одной из них, позволившая определить серию находок и их название – плешки (плещки), использовавшееся самими мастерами.

The paper reports on attribution of rare stone items called pleshchkas, i. e. special stone notebooks, an equivalent of medieval wax tablets used for making notes and drawings. They were part of stone carvers’ toolkits and were used in training and improving techniques of carving, drawing and making inscriptions on stone. An inscription on one of the items was used to identify the items as a series of finds and understand how stone carvers called them (pleshkas, or pleshchkas).
Woden Items of Horse Trapings from the Dargavs Catacomb Cemetery in North Ossetia
Authors: Успенский П.С. , Албегова З.Х.
Published: September 2024

Статья посвящена анализу деревянных предметов конского снаряжения из средневекового катакомбного могильника Даргавс аланской культуры, расположенного в Северной Осетии. Все анализируемые предметы происходят из погребений середины VIII – начала IX в. Подробно рассмотрена морфология двух фрагментов деревянных плетей, деревянного стремени и гребня. Полученные выводы расширяют наши представления о составляющих элементах конского снаряжения, используемого в среде аланского населения

The paper analyzes wooden items of horse trappings from Dargavs, which is a medieval catacomb cemetery of the Alan culture located in North Ossetia. All items analyzed originate from graves of the mid-8th – early 9th centuries. Morphology of two fragments of wooden lashes, a wooden stirrup and a comb is discussed in details. The conclusions presented in the paper expand our knowledge on horse equipment components used by the Alan population
The Khujistanid Dirham from Excavations at the Ryurikovo Gorodishche
Authors: Гомзин А.А.
Published: September 2024

В статье рассматривается худжистанидский дирхам, чеканенный в Нисабуре в 268 г. х. (881/882 г.) и найденный в 2011 г. при раскопках на Рюриковом городище. Эта редкая и красивая по оформлению монета обязана своим происхождением бурным историческим событиям, имевшим место в 870–880-е гг. в Хорасане. Она же является свидетельством некоторых особенностей обращения и использования куфических монет в бассейне Ильменя и Волхова. Для данного региона это первая и пока единственная подобная находка.

The paper reports on a Khujistanid dirham minted in Naysābūr in A. H. 268 (AD 881/882) discovered during excavations at Ryurikovo Gorodishche in 2011. This rare and beautifully designed coin owes its origin to tumultuous historical events which took place in Khurasan in the 870s–880s. It also demonstrates some specific features of circulation and use of Kufic coins in the Ilmen and Volkhov valley. So far it is the first and only find of this kind discovered in this region.