bluuebunny/crossref_metadata_2025 huggingface dataset:
The correlation of deep learning-based CAD-RADS evaluated by coronary computed tomography angiography with breast arterial calcification on mammography
Authors: Huang Zengfa , Xiao Jianwei , Xie Yuanliang , Hu Yun , Zhang Shutong , Li Xiang , Wang Zheng , Li Zuoqin , Wang Xiang
Published: July 2020

This study sought to evaluate the association of breast arterial calcification (BAC) on breast screening mammography with the Coronary Artery Disease-Reporting and Data System (CAD-RADS) based on Deep Learning-coronary computed tomography angiography (CCTA). This prospective single institution study included asymptomatic women over 40 who underwent CCTA and breast cancer screening mammography between July 2018 and April 2019. CAD-RADS was scored based on Deep Learning (DL). Mammograms were assessed visually for the presence of BAC. A total of 213 patients were included in the analysis. In comparison to the low CAD-RADS (CAD-RADS < 3) group, the high CAD-RADS (CAD-RADS ≥ 3) group, more often had a history of hypertension (P = 0.036), diabetes (P = 0.017), and chronic kidney disease (P = 0.006). They also had a significantly higher level of LDL-C (P = 0.024), while HDL-C was lower than in the low CAD-RADS group (P = 0.003). BAC was also significantly higher in the high CAD-RADS group (P = 0.002). In multivariate analysis, the presence of BAC [odd ratio (OR) 10.22, 95% CI 2.86–36.49, P < 0.001] maintained a significant associations with CAD-RADS after adjustment by meaningful variable. The same tendency was also found after adjustment by all covariates. There was a significant correlation between the severities of CAD detected by DL based CCTA and BAC in women undergoing breast screening mammography. BAC may be used as an additional diagnostic tool to predict the severity of CAD in this population.
Estimating the efficacy of symptom-based screening for COVID-19
Authors: Callahan Alison , Steinberg Ethan , Fries Jason A. , Gombar Saurabh , Patel Birju , Corbin Conor K. , Shah Nigam H.
Published: July 2020

There is substantial interest in using presenting symptoms to prioritize testing for COVID-19 and establish symptom-based surveillance. However, little is currently known about the specificity of COVID-19 symptoms. To assess the feasibility of symptom-based screening for COVID-19, we used data from tests for common respiratory viruses and SARS-CoV-2 in our health system to measure the ability to correctly classify virus test results based on presenting symptoms. Based on these results, symptom-based screening may not be an effective strategy to identify individuals who should be tested for SARS-CoV-2 infection or to obtain a leading indicator of new COVID-19 cases.
Carbodiimide-based synthesis of N-heterocycles: moving from two classical reactive sites to chemical bond breaking/forming reaction
Authors: Wang Yang , Zhang Wen-Xiong , Xi Zhenfeng
Published: July 2020

The extensive synthetic application of carbodiimides in various types of N-heterocyclic systems from the 1980s to today is outlined.
One-pot synthesis of a carbon dots@zeolitic imidazolate framework-8 composite for enhanced Cu2+ sensing
Authors: Guo Hao , Wang Xiaoqiong , Wu Ning , Xu Mengni , Wang Mingyue , Zhang Longwen , Yang Wu
Published: July 2020

A novel composite (CDs@ZIF-8) based on carbon dots (CDs) and a zeolitic imidazolate framework (ZIF-8) was successfully synthesized by encapsulating CDs into the pores of ZIF-8 through a simple one-pot solvothermal method.
Haemoglobin(βK120C)–albumin trimer as an artificial O2carrier with sufficient haemoglobin allostery
Authors: Morita Yoshitsugu , Saito Asuka , Yamaguchi Jun , Komatsu Teruyuki
Published: July 2020

Recombinant haemoglobin [rHb(βK120C)] was coupled with two human serum albumins (HSAs), yielding a rHb(βK120C)–HSA2heterotrimer, which shows a sigmoidal O2equilibrium curve and sufficient Hb allostery identical to those of native Hb.
Multicolour photochromic fluorescence of a fluorophore encapsulated in a metal–organic framework
Authors: Hirai Kenji , Kitagawa Taisei , Fujiwara Hideki , Pirillo Jenny , Hijikata Yuh , Inose Tomoko , Uji-i Hiroshi
Published: July 2020

A fluorophore encapsulated in a metal–organic framework showed photochromic multicolour fluorescence.
Morphology transformation of pillararene-based supramolecular nanostructures
Authors: Ding Jin-Dong , Jin Wen-Juan , Pei Zhichao , Pei Yuxin
Published: July 2020

In this feature article, the construction methods and the factors that influence the morphological transformation of pillararene-based supramolecular nanostructures are reviewed.
Cu3P nanoparticle-reduced graphene oxide hybrid: an efficient electrocatalyst to realize N2-to-NH3 conversion under ambient conditions
Authors: Zhao Runbo , Geng Qin , Chang Le , Wei Peipei , Luo Yonglan , Shi Xifeng , Asiri Abdullah M. , Lu Siyu , Wang Zhiming , Sun Xuping
Published: July 2020

For electrocatalytic N2-to-NH3 fixation, a Cu3P-rGO nanohybrid affords a Faradic efficiency of 10.11% with a NH3 yield of 26.38 μg h−1 mgcat.−1 at −0.45 V vs. RHE.
The ultralong cycle life of solid flexible asymmetric supercapacitors based on nickel vanadium sulfide nanospheres
Authors: Li Yuanyuan , Chen Xin , Cao Yali , Zhou Wanyong , Chai Hui
Published: July 2020

The nickel vanadium sulfide electrodes shows an capacitance of 697.4 C g−1 at current density of 1A g−1. The flexible ACS Ni–V–S–2//rGO gives rise to a remarkable cyclic stability with 100% capacitance retention over 7000 charge–discharge cycles.
Two-dimensional radical–cationic Mott insulator based on an electron donor containing neither a tetrathiafulvalene nor tetrathiapentalene skeleton
Authors: Kadoya Tomofumi , Sugiura Shiori , Tahara Keishiro , Higashino Toshiki , Kubo Kazuya , Sasaki Takahiko , Takimiya Kazuo , Yamada Jun-ichi
Published: July 2020

We have succeeded in developing a two-dimensional radical–cationic Mott insulator that does not contain a 1,3-dithiol-2-ylidene moiety.
On the mechanism of soot nucleation. II. E-bridge formation at the PAH bay
Authors: Semenikhin Alexander S. , Savchenkova Anna S. , Chechet Ivan V. , Matveev Sergey G. , Frenklach Michael , Mebel Alexander M.
Published: July 2020

A model combining both the bay and zigzag rotationally-induced formation of E-bridges between PAH molecules increases nucleation rates and affirms the rotationally-activated dimerization as a feasible mechanism for soot particle nucleation.
Rare-earth metal–organic frameworks: from structure to applications
Authors: Saraci Felix , Quezada-Novoa Victor , Donnarumma P. Rafael , Howarth Ashlee J.
Published: July 2020

In the past 30 years, rare-earth metal–organic frameworks (MOFs) have been gaining attention owing to their diverse chemical structures, and tunable properties.
Size dependent oxygen reduction and methanol oxidation reactions: catalytic activities of PtCu octahedral nanocrystals
Authors: Polani Shlomi , Shviro Meital , Shokhen Victor , Zysler Melina , Glüsen Andreas , Dunin-Borkowski Rafal , Carmo Marcelo , Zitoun David
Published: July 2020

Synthesis of PtCu octahedral nanocatalysts with controlled size and strain exhibit excellent oxygen reduction reaction, but leads to higher onset over-potentials in methanol oxidation reaction and CO-stripping.
Insight into the effects of electronegativity on the H2 catalytic activation for CO2 hydrogenation: four transition metal cases from a DFT study
Authors: Chen Haipeng , Yang Minjian , Liu Jinqiang , Lu Guojian , Feng Xun
Published: July 2020

Electronegativity of transition metal dominates the type of H species, which has an important effect on the path choice of CO2 hydrogenation.
Techno-economic viability of islanded green ammonia as a carbon-free energy vector and as a substitute for conventional production
Authors: Nayak-Luke Richard Michael , Bañares-Alcántara René
Published: July 2020

Evaluation of islanded green ammonia production's economic viability at 534 locations worldwide showing competitiveness by 2030.
Lignin-fueled photoelectrochemical platform for light-driven redox biotransformation
Authors: Wang Ding , Lee Sahng Ha , Han Seunghyun , Kim Jinhyun , Trang Nguyen Vu Thien , Kim Kayoung , Choi Eun-Gyu , Boonmongkolras Passarut , Lee Yang Woo , Shin Byungha , Kim Yong Hwan , Park Chan Beum
Published: July 2020

A bias-free photoelectrochemical oxidation of lignin in a tandem photoanode/PV structure is coupled with bioelectrocatalytic reductions (e.g., CO2 to formate and α-ketoglutarate to l-glutamate).
Towards bioproduction of poly-α-olefins from lignocellulose
Authors: Salmela Milla , Lehtinen Tapio , Efimova Elena , Santala Suvi , Santala Ville
Published: July 2020

Biological platform for linear-α-olefin production from lignocellulose (technical lignin and cellulose) and chemical oligomerization to poly-α-olefins.
Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: redox and biological implications
Authors: Almeida Renata G. , Valença Wagner O. , Rosa Luísa G. , de Simone Carlos A. , de Castro Solange L. , Barbosa Juliana M. C. , Pinheiro Daniel P. , Paier Carlos R. K. , de Carvalho Guilherme G. C. , Pessoa Claudia , Goulart Marilia O. F. , Kharma Ammar , da Silva Júnior Eufrânio N.
Published: July 2020

New quinoidal compounds were prepared and evaluated against T. cruzi and cancer cell lines for the identification of new bioactive agents.
Poly-d-lysine coated nanoparticles to identify pro-inflammatory macrophages
Authors: Hernandez Derek S. , Schunk Hattie C. , Shankar Karan M. , Rosales Adrianne M. , Suggs Laura J.
Published: July 2020

Identifying pro-inflammatory macrophages (M1) is of immense importance to diagnose, monitor, and treat various pathologies. Here, we present a poly-D-lysine coated nanoparticle for real-time fluorescent labeling of M1 macrophages.
Polycationic gold nanorods as multipurposein vitromicrotubule markers
Authors: Wedler Viktoria , Strauß Fabian , Sudhakar Swathi , Hermsdorf Gero Lutz , Stierhof York-Dieter , Schäffer Erik
Published: July 2020

Polycationic gold nanorods (AuNRs) electrostatically bind microtubules. Bleach and blinkfree photoluminescence of these AuNRs makes them excellent microtubule markers.
Multi-stimuli responsive heterotypic hydrogels based on nucleolipids show selective dye adsorption
Authors: Nuthanakanti Ashok , Srivatsan Seergazhi G.
Published: July 2020

A heterotypic hydrogel system formed by partial hydrolysis of 5′-O-fatty acid-conjugated ribothymidine and uridine nucleolipids exhibits reversible multi-stimuli responsiveness and selective dye adsorption.
Deciphering the excited state intramolecular charge-coupled double proton transfer in an asymmetric quinoline–benzimidazole system
Authors: Kumar Gulshan , Paul Kamaldeep , Luxami Vijay
Published: July 2020

Asymmetrical H-bonding responsible for charge coupled-excited state intramolecular double proton transfer.
On-site formation of small Ag nanoparticles on superhydrophobic mesoporous silica for antibacterial application
Authors: Yang Zhu , Wu Chunhua , Kanamori Kazuyoshi , Kamei Toshiyuki , Shimada Toyoshi , Nakanishi Kazuki
Published: July 2020

A superhydrophobic mesoporous silica material loaded with on-site formed small Ag nanoparticles has been prepared via surface modification with octadecylsilane (C18H37SiH3) and subsequent reduction of silver ions with residual hydrido groups on-site.
Switchable superlyophobic zeolitic imidazolate framework-8 film-coated stainless-steel meshes for selective oil–water emulsion separation with high flux
Authors: Gao Xin , Ma Qiang , Jin Zhengwei , Nian Pei , Wang Zheng
Published: July 2020

A switchable superlyophobic ZIF-8 membrane can selectively remove oil droplets in oil-in-water emulsions via superoleophobicity and water droplets in water-in-oil emulsions via superhydrophobicity.
Co/Ni-MOF-74-derived CoNi2S4 nanoparticles embedded in porous carbon as a high performance anode material for sodium ion batteries
Authors: Xu Tingting , Zhao Jiachang , Li Lanjie , Mao Jianfeng , Xu Jingli , Zhao Hongbin
Published: July 2020

In this study, Co/Ni-MOF-74-derived CoNi2S4 nanoparticles embedded in porous carbon (CoNi2S4@C) were successfully prepared using Co/Ni-MOF-74 as precursor. And, CoNi2S4@C exhibits excellent electrochemical performance as an anode material for sodium ion batteries.
Security use of the chiral photonic film made of helical liquid crystal structures
Authors: Park Wongi , Ha Taewoo , Jung Taek Sun , Sim Kyung Ik , Kim Jae Hoon , Wolska Joanna M. , Pociecha Damian , Gorecka Ewa , Kim Teun-Teun , Yoon Dong Ki
Published: July 2020

We designed a security-enhanced anti-counterfeiting tag using chiral photonic crystal films, which has polarization-dependent transmission color changes.
Effects of the tetrahedral framework nucleic acids on the skeletal muscle regeneration in vitro and in vivo
Authors: Gao Yang , Zhang Tianxu , Zhu Junyao , Xiao Dexuan , Zhang Mei , Sun Yue , Li Yanjing , Lin Yunfeng , Cai XiaoXiao
Published: July 2020

The challenges associated with muscle degenerative diseases and volumetric muscle loss (VML) emphasizes the prospects of muscle tissue regeneration.
Nickel-catalyzed dual C(sp2)–H activation of arenes: a new route to diaryl ethers
Authors: Lv Ningning , Chen Zhengkai , Yu Shuling , Liu Zhanxiang , Zhang Yuhong
Published: July 2020

Diaryl ethers are synthesized directly from simple arenes for the first time through dual C(sp2)–H activation with the aid of a bidentate auxiliary by nickel catalysis. The auxiliary can be removed smoothly under mild reaction conditions.
Synthesis and high-pressure studies of strontium diazenide by synchrotron X-ray diffraction and DFT calculations
Authors: Li Yue , Bu Huanpeng , Wang Qinglin , Lin Jiani , Wang Xiaoli , Li Jianfu , Zhu Pinwen , Zhu Hongyang
Published: July 2020

In this work, strontium diazenide (SrN2) was synthesized using strontium azide as a starting material in a Walker-type module under high-pressure and high-temperature conditions.
Origami-based “Book” shaped three-dimensional electrochemical paper microdevice for sample-to-answer detection of pathogens
Authors: He Tao , Li Jingwen , Liu Lisheng , Ge Shenguang , Yan Mei , Liu Haiyun , Yu Jinghua
Published: July 2020

Herein, an ease-of-use and highly sensitive origami-based “book” shaped three-dimensional electrochemical paper microdevice based on nucleic acid testing (NAT) methodology was developed for sample-to-answer detection of pathogens from whole blood and food samples.
A sensitive fluorometric sensor for Ag+ based on the hybridization chain reaction coupled with a glucose oxidase dual-signal amplification strategy
Authors: Li Yubin , Xie Ling , Yuan Jiaming , Liu Huazhong
Published: July 2020

An assay for Ag+ based on a C–Ag+–C structure by utilizing a HCR/GOx dual-signal amplification strategy and SCGS as an ideal separation material.
The structure and vibrational spectroscopy of cryolite, Na3AlF6
Authors: Parker Stewart F. , Ramirez-Cuesta Anibal J. , Daemen Luke L.
Published: July 2020

We use a combination of infrared, Raman and inelastic neutron scattering spectroscopies to access all of the modes of cryolite, Na3[AlF6], including those that are forbidden to the optical spectroscopies.
Optimization extraction and characterization of Artemisia ordosica polysaccharide and its beneficial effects on antioxidant function and gut microbiota in rats
Authors: Xing Y. Y. , Xu Y. Q. , Jin X. , Shi L. L. , Guo S. W. , Yan S. M. , Shi B. L.
Published: July 2020

Artemisia ordosica polysaccharide is expected to be functional ingredient for health improvement through improving antioxidant ability and modulating gut health.
Influence of salt concentration on the formation of Pickering emulsions
Authors: French David J. , Fowler Jeff , Taylor Phil , Clegg Paul S.
Published: July 2020

Confocal micrograph z-projection (left) and confocal micrograph (right) of oil droplets stabilised by colloidal silica as the concentration of NaCl is increased. The scale bars are 20 μm.
Tin disulfide–graphene oxide-β-cyclodextrin mediated electro-oxidation of melatonin hormone: an efficient platform for electrochemical sensing
Authors: Liu Xinrui , Sakthivel Rajalakshmi , Chen Yu-Cheng , Chang Ning , Dhawan Udesh , Li Yunqian , Zhao Gang , Lin Chingpo , Chung Ren-Jei
Published: July 2020

We have developed an electrochemical sensor based on integrated 2D materials including SnS2, graphene oxide, and β-cyclodextrin forming a ternary nanocomposite decorated on a screen-printed electrode for the electrochemical detection of melatonin.
In situ activated mesenchymal stem cells (MSCs) by bioactive hydrogels for myocardial infarction treatment
Authors: Gao Long , Yi Min , Xing Min , Li Hekai , Zhou Yanling , Xu Qing , Zhang Zhaowenbin , Wen Zhanpeng , Chang Jiang
Published: July 2020

A novel bioglass composite hydrogel that in situ activates mesenchymal stem cells for the treatment of myocardial infarction.
Directional and ultrafast migrations of excitons/biexcitons in organic polymers by utilizing a local nonuniform electric field
Authors: Zhang Maomao , Qin Wei , Li Yuan , Gao Kun
Published: July 2020

Optoelectronic modulation of organic devices by manipulating the directional and ultrafast migration of excitons as well as biexcitons.
A bifacial colour-tunable system via combination of a cholesteric liquid crystal network and hydrogel
Authors: Wani Owies M. , Schenning Albertus P. H. J. , Priimagi Arri
Published: July 2020

We present a colour tunable system obtained by combining a humidity-responsive cholesteric liquid crystal network and hydrogel coatings, in a diligently designed cell-geometry.
A pleasant blue-green colored 2D vanadium dioxide inverse opal monolayer: large area fabrication and its thermochromic application
Authors: Li Hua , Djaoued Habiba , Robichaud Jacques , Djaoued Yahia
Published: July 2020

2D VO2 IO film with a pleasant blue-green color is fabricated by an improved “dynamic hard-template” infiltration strategy.
All MoS2 based 2D/0D localized unipolar heterojunctions as flexible broadband (UV-vis-NIR) photodetectors
Authors: Selamneni Venkatarao , Ganeshan Sankalp Koduvayur , Sahatiya Parikshit
Published: July 2020

In this work, we demonstrate, for the first time, a one-pot synthesized MoS2 based 2D/0D flexible broadband (UV-vis-NIR) photodetector.
Robust single-mode lasers based on hexagonal CdS microflakes
Authors: Mi Yang , Wu Yaoyao , Shi Jinchun , Luo Sheng-Nian
Published: July 2020

We have achieved single-mode whispering-gallery-mode lasing in CdS microflakes with sharp linewidth (∼0.12 nm) and high quality factor (∼4200). Such lasers are superior to previous CdS lasers in these lasing parameters. Through time-resolved photoluminescence measurements, electron–hole plasma recombination is established to be the lasing mechanism. The radiative recombination rate of CdS microflakes is enhanced by a factor of ∼4.7 due to the Purcell effect.
Resolving the discrepancies in the reported optical absorption of low-dimensional non-toxic perovskites, Cs3Bi2Br9 and Cs3BiBr6
Authors: Tran Minh N. , Cleveland Iver J. , Aydil Eray S.
Published: July 2020

[BiBr6]3− octahedra behave as QDs whether in solid or in solution state, explaining conflicting absorption spectra reported for low-dimensional perovskite, Cs3Bi2Br9.
Controlling gene expression with light: a multidisciplinary endeavour
Authors: Hartmann Denis , Smith Jefferson M. , Mazzotti Giacomo , Chowdhry Razia , Booth Michael J.
Published: July 2020

The expression of a gene to a protein is one of the most vital biological processes. The use of light to control biology offers unparalleled spatiotemporal resolution from an external, orthogonal signal. A variety of methods have been developed that use light to control the steps of transcription and translation of specific genes into proteins, for cell-free to in vivo biotechnology applications. These methods employ techniques ranging from the modification of small molecules, nucleic acids and proteins with photocages, to the engineering of proteins involved in gene expression using naturally light-sensitive proteins. Although the majority of currently available technologies employ ultraviolet light, there has been a recent increase in the use of functionalities that work at longer wavelengths of light, to minimise cellular damage and increase tissue penetration. Here, we discuss the different chemical and biological methods employed to control gene expression, while also highlighting the central themes and the most exciting applications within this diverse field.
Functional Near-Infrared Spectroscopy in the Study of Speech and Language Impairment Across the Life Span: A Systematic Review
Authors: Butler Lindsay K. , Kiran Swathi , Tager-Flusberg Helen
Published: July 2020

Purpose

Functional brain imaging is playing an increasingly important role in the diagnosis and treatment of communication disorders, yet many populations and settings are incompatible with functional magnetic resonance imaging and other commonly used techniques. We conducted a systematic review of neuroimaging studies using functional near-infrared spectroscopy (fNIRS) with individuals with speech or language impairment across the life span. We aimed to answer the following question: To what extent has fNIRS been used to investigate the neural correlates of speech-language impairment?

Method

This systematic review was preregistered with PROSPERO, the international prospective register of systematic reviews (CRD42019136464). We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol for preferred reporting items for systematic reviews. The database searches were conducted between February and March of 2019 with the following search terms: (a) fNIRS or functional near-infrared spectroscopy or NIRS or near-infrared spectroscopy, (b) speech or language, and (c) disorder or impairment or delay.

Results

We found 34 fNIRS studies that involved individuals with speech or language impairment across nine categories: (a) autism spectrum disorders; (b) developmental speech and language disorders; (c) cochlear implantation and deafness; (d) dementia, dementia of the Alzheimer's type, and mild cognitive impairment; (e) locked-in syndrome; (f) neurologic speech disorders/dysarthria; (g) stroke/aphasia; (h) stuttering; and (i) traumatic brain injury.

Conclusions

Though it is not without inherent challenges, fNIRS may have advantages over other neuroimaging techniques in the areas of speech and language impairment. fNIRS has clinical applications that may lead to improved early and differential diagnosis, increase our understanding of response to treatment, improve neuroprosthetic functioning, and advance neurofeedback.
Separation of magnetite concentrate before the last grinding stage
Authors: Pelevin Aleksei , Saitov Vil , Dmitriev Vladimir
Published: July 2020

For magnetite and titanium magnetite ores, it is possible to use technology with the separation of concentrate before the last grinding stage. The possibility of staged separation of iron concentrate is due to different physical-mechanical properties of magnetite and rock minerals. The results of industrial and laboratory tests on the use of special magnetic separators with special structure, Derrick screen and screw separators in iron ore dressing schemes are presented. A comparison of proven dressing methods is performed. The choice of a specific dressing method for the staged separation of magnetite concentrate before the last grinding stage is determined by the properties of the base ore and the economic justification.
Geophysical surveys of rock mass status of iron ore deposit with combined deep – opencast mining zone
Authors: Vedernikov Andrey , Zuev Pavel , Grigoriev Danila
Published: July 2020

Often in deposits developed by underground mining, the task is to control the state of the earth's surface within the mine field. And this problem is even more acute in the case of combined open-underground mining. The Goroblagodatskoe iron ore deposit has been developed by a combined method for more than 40 years. The article describes the methodology and results of applying the geophysical diagnostic method at a mining facility developed by a combined open-underground method - the spectral seismic profiling method (SSP). The application of this method is justified. This method has shown its sufficient efficiency in terms of time costs and sufficient reliability for local studies. The results of field and desk studies are obtained, an assessment of the nature of the object is given, which justifies the use of further measures for the safe development of the object.
Analysis of methods for assessing the drilling tool performance
Authors: Simisinov Denis , Porozhkiy Konstantin , Pozdnyakova Olga , Zakharov Ivan
Published: July 2020

The analysis of methods for assessing the drilling tool performance using various methods was performed. The applicability of the methods was assessed. Methods based on periodic comparative tests were examined in detail. The technical level and operational efficiency of the drilling tool is determined by the resource (tool driftage), drilling speed, durability, power supplied to the bottom of the well. The correct choice of a drilling tool is ultimately determined by economic assessments. The specific drilling costs are proposed to be determined taking into account the cost of one machine hour, the sharpening of crowns and the average mechanical drilling speed.
Remote-controlled robotic complex for underground mining
Authors: Tauger Vitalii , Valiev Niyaz , Volkov Evgenii , Simisinov Denis , Adas Vitalii
Published: July 2020

As the global rich mineral deposits are becoming depleted, the deposit development is performed with a deeper bedding and in much more difficult mining and geological conditions. This circumstance determines both the increase in the labor intensity and development costs, and the increased likelihood of emergencies. In recent years, the accidents have become more frequent at the Russian mining enterprises, aggravated not only by the significant damages, but also by the casualties. The ongoing efforts to correct the tight situation do not have a perceptible effect. A complete exclusion of the presence of people underground should be considered as a drastic remedy for preventing human casualties. It can be achieved only through the use of machinery and technology for manless mining using the automated control systems. The Department of Engineering Mechanics of the Ural State Mining University has formed the concept of a “remote-controlled robotic complex for underground mining”, according to which a surface-controlled system of mining equipment will absolve the miners from working underground. At present, the favorable conditions have been laid for combining the in-mine equipment and permanent installations into a single complex under the control of operators located on the soil surface. In accordance with the concept, the technological robotic complex is transformed into a mechatronic system of the underground mining equipment. The mechatronic system is divided into the separate subsystems by the types of equipment. Particular attention is paid to the automated complex remote-control system based on the telemetry principles using the latest means of data acquisition, conversion and transmission. The system interface provides the most efficient and error-free performance of the operator throughout the entire shift. The concept implementation of the remote-controlled robotic complex in the mining industry will allow not only to avoid the tragic consequences of emergencies in the mines, but also to elevate the national mining equipment and technology to the highest world standards.
Features of the tripping mechanization with the horizontal pipe laying
Authors: Markelov Aleksey , Gavrilova Lyudmila , Belov Sergey
Published: July 2020

The relevance of the work is due to the need of the oil industry in the tripping mechanization when working with the drilling, casing and compressor tubes with simultaneous reduction in the installation, disassembly and transportation of the pipe storage units while ensuring the required technological capabilities. The purpose of the article is to consider the possible design improvement of the mechanized V-door ramp in order to simplify the oil well construction or repair. The article presents an analysis of existing equipment for the operation mechanization with the horizontal pipe laying, as one of the most common type of laying. The requirements for the mechanized V-door ramp are determined. The advantages of automation of the drill-pipe connection operations using the mechanized V-door ramps are analyzed. The results are as follows: the functional analysis of the means and equipment for the tripping mechanization allows to compile the functional and constructive classification of pipe stand receivers and mechanized V-door ramps. The task is set to use the systematic approach to find the ways for the efficiency improvement of the tripping mechanization means with the horizontal pipe laying.
Improvement of rock-breaking tools of heading-and-winning machine of potash mines
Authors: Shishlyannikov Dmitrij , Suhanov Andrej
Published: July 2020

Conducted a statistic research of the construction features of heading-and-winning machine actuator members for the extraction of potash ores. It is shown that increasing the efficiency of the destruction process of a potash massif with the cutters of heading-and-winning machine actuator members is possible by means of the potential cross-cutting technique. The methods of potash layers destruction by cross cuts were considered. Designs of the heading-and-winning machine actuator members that implement the cross-cutting scheme of potash massif are presented.
Economic component of environmental safety of urban territories with the functioning of thermal energy sources
Authors: Pashentsev Alexandr , Garmider Anna , Finogentova Anna , Shakhova Natalia , Statsenko Evgenia
Published: July 2020

The essence of the concept of environmental safety of urban areas from the impact of boiler houses is justified on the basis of the synthesis of this definition of domestic scientists. A method for calculation of the indicator of environmental safety of urban areas based on the balance approach, which is based on the comparison of data on anthropogenic pressure exerted by boiler houses on the components of the environment and the ecological capacity of territories, was edveloped. Classification interval estimates of the ecological safety indicator of urban areas have been developed with a brief description, the economic essence of the ecological safety of these territories with a justification of relationship between the environmental, technical, and economic indicators has been proved.
Estimation of parameters of elements of the technogenic landscape of the Degtyarsk post-exploitation zone with the use of unmanned aerial vehicles
Authors: Elokhina Svetlana , Kindler Alexey , Afanasenko Ekaterina
Published: July 2020

The article provides an example of the practical use of unmanned aerial vehicles as one of the methods for collecting geospatial data within the framework of state monitoring of the subsoil condition. The Degtyarsk post-exploitation zone was selected as the object under consideration.
Legal aspects of quarry recultivation using the municipal solid waste
Authors: Byvaltseva Svetlana
Published: July 2020

The article is devoted to the study of legal issues of the quarry recultivation using the municipal solid waste. In recent years, insufficient attention has been paid to this problem in the scientific literature that is related to the statutory ban on the quarry recultivation with the municipal solid waste, introduced in 2014. Meanwhile, the problem of increasing the areas disturbed by both the resource development and the waste disposal is becoming truly catastrophic. In order to determine the legal possibility of solving this issue, the study was performed in relation the legal aspects of the quarry recultivation and the municipal solid waste disposal. Based on the study, the author concludes that the solution to this problem is possible in two planes - by changing the applicable legislation or by implementing the quarry recultivation using the waste in two stages in accordance with the applicable legislation.
Objective and subjective factors in the environmental safety concept of industrial territories of the Ural district
Authors: Lebedev Yu.V. , Tyabotov I.A. , Belov V.V. , Stikhin A.A.
Published: July 2020

The objective and subjective factors in the environmental safety concept are considered. The idea of environmental safety in an industrial area includes the following: to breathe clean air, drink clean water, and consume safely grown products. The ways (methods) of forming environmental safety are proposed.
Resource conservation as a condition for preserving non-renewable natural capital
Authors: Strovsky Vladimir , Logvinenko Oksana , Moor Irina , Pustokhina Natalia
Published: July 2020

The article overviews the problem of slowing down the rates of natural non-renewable sources depletion in the process of resources development. The goal of the presented research is to justify the implementation of the most appropriate method of carrying out a complete resource development process by incorporating the mining and raw material extraction facilities available in the country. The study provides scientific evidence of a large-scale harmful impact caused by the raw materials development to all the elements of the biosphere and their interdependence. The presented research also demonstrates that solving the problem of resource-conservation is a first-hand priority due to the fact that there is in a close interconnection between the levels of environmental pollution and the levels of natural resources extraction. The solution to the problem of natural resources conservation is based on the concept of implementing environmentally clean technology (ECT); this technology gives an opportunity for developing a concept of the best available technology (BAT) and the concept of a closed-loop supply, the latter of which has become widely-used as a form of circular economy. The authors of the article have also suggested a systematic range of techniques aimed at extracting following resources in full capacity: commercial resources, non¬commercial resources, overburden rocks and man-made mineral formations. The authors of the article suggest the necessity for enlarging the scope of available mineral resources by ensuring governmental support and developing small deposits, first and foremost focusing on the territories with a developed infrastructure and which had previously been developed. The ideas presented in the article express and support the necessity for prospective implementation of the mining factories waste products as a reserve for mineral and raw materials resources; as well as the necessity for increasing their production rates from the circular economy perspective. Some measures which would help to accelerate this process are: improving the legislative system, developing mechanisms for economic incentive and providing various forms of state-business co¬operation.
Mining cities are a special type of cities of a traditionally industrial region
Authors: Dvoryadkina Elena , Jalilov Elvin
Published: July 2020

The article is devoted to the study of theoretical aspects of mining cities as a special type of cities in a traditionally industrial region. Industry appears both as a factor of cities formation and as the basis for the economic functions of the vast majority of Russian cities. The predominant type of cities are monocities with industry based. It is the combination of cities with a pronounced industrial function, which is steadily implemented over a long period of time, that forms the profile and trajectory of the traditionally industrial region development. The purpose of this article is to identify mining cities as a special type of cities inherent in the traditionally industrial region. The main method of research was the method of typology: the typologies of cities were generalized, industry criteria of typologies were characterized. The result of the study is the justification of mining cities as cities of regional type. The presence of mining cities acts as one of the features (properties) of a traditionally industrial region.
Methodological approach to risk-assignment for joint ventures in energy industry
Authors: Dudnik Anna
Published: July 2020

The article provides guidance about risk allotment regarding to joint ventures operating in energy industry. Energy industry has been overwhelmed by risk, in compare to other branches. To diminish the chance of failure on international partnership, risk management techniques should be based on methodological principals. The paper presents outlook to risk in response to the stage of a joint project. The methodological approach is structured in accordance with risk group hierarchy received with Delphi evaluation method. Thus, joint ventures parties are allowed to complete an effective review in order to implement risk reduction actions.
Mining and hydraulic engineering structures as commercialized facilities
Authors: Konovalov Vladimir , Yershova Tatyana , Bedrina Svetlana
Published: July 2020

About 70 acting and inactive mining and hydraulic engineering structures containing considerable number of valuable components have been identified in the Ural mining region, suggesting that they can be viewed as man-made mineral fields. The paper studies an optional approach to identify these structures as real estate assets with their further record in the Unified State Register of Immovable Property and their commercialization.
Taurin
Authors: Gröber Uwe
Published: July 2020

Taurin ist eine nicht proteinogene Aminosäure mit hohen Gewebskonzentrationen in Gehirn und Herz sowie im ZNS. Absolut gesehen befindet sich die größte Menge Taurin in der Muskulatur. Aufgrund seiner zahlreichen Funktionen im Stoffwechsel und in verschiedenen Organen sind die Symptome eines Mangels weitreichend. Die Supplementierung von Taurin ist bei zahlreichen Erkrankungen indiziert.
Oncogenic KRAS Drives Metabolic Vulnerabilities by Directly Regulating Metabolic Enzymes in Cancer
Authors: Zhang Liyi
Published: July 2020

Metabolic reprogramming, such as enhanced aerobic glycolysis, allows cancer cells to maintain viability and promote proliferation. It is one of the major consequences of oncogenic mutations. KRAS is the most frequently mutated oncogene in human cancer. It is thought to be closely related to metabolic reprogramming. However, it is not clear whether it can participate in metabolic reprogramming by directly regulating metabolic enzymes. Additionally, the functional differences among the splice variants of KRAS have not been determined. In a study, recently published in Nature, Amendola et al reported a unique interaction between one of the KRAS splice variants (KRAS4A) and the major glycolytic enzyme (hexokinase 1) in cancer cells. Their findings indicated that a better understanding on the regulation of hexokinase 1 by KRAS may reveal novel therapeutic strategies.
Renal Calculi as Initial Presenting Symptom of Glycogen Storage Disease (Type 1 A) in Early Infancy
Authors: Mirza Nida , Malhotra Smita , Sibal Anupam
Published: July 2020

Glycogen storage diseases are a group of heterogeneous metabolic disorders that result from a defect in enzymatic pathway of either glycogen synthesis or glycogen degradation. Here we are reporting a case of glycogen storage diseases type 1 with renal stone as initial manifestation of disease at 2 months of age. There were case reports of recurrent renal calculi in older age group with this disease and considered to be arisen due to metabolic derangements. Although the exact mechanism of renal stones in glycogen storage disease is not clear, in this unique case occurrence of renal stones at 2 months of age suggests that the pathogenesis of renal calculi is probably multifactorial or a part of disease.
Predicting Which Clinically Documented Incidents of Aggression Lead to Findings of Guilt in a Forensic Psychiatric Sample
Authors: Seto Michael C. , Charette Yanick , Nicholls Tonia L. , Crocker Anne G.
Published: July 2020

This study identified factors that predicted which of 713 clinically documented incidents of aggression—threats to kill, assault, or sexual assault—committed by 404 forensic psychiatric patients were linked to court findings of guilt. Individuals had, on average, 1.7 aggressive incidents and were found guilty of an average of 0.3 offenses against persons during the study period. Aggressive incidents were mostly assaults, followed by uttering death threats, and sexual assaults. The victims of aggressive incidents were mainly other patients or staff, but some incidents involved family members or friends (16%) and strangers (14%). Most of the aggressive incidents (84%) did not lead to findings of guilt. Incidents of aggression linked to court findings were significantly associated with province; personality disorder; fewer prior aggressive incidents; and incidents involving strangers compared to staff or co-patients or to family or friends. These findings have implications for research in terms of understanding how criminal records underestimate histories of aggression. These findings also point to the need for the development of more consistent policies and procedures for responding to patient aggression, including when it is necessary or productive to report to police.
miRNA‐ and cytokine‐associated extracellular vesicles mediate squamous cell carcinomas
Authors: Flemming Joseph P. , Hill Brianna L. , Haque Mohammed W. , Raad Jessica , Bonder Claudine S. , Harshyne Larry A. , Rodeck Ulrich , Luginbuhl Adam , Wahl James K. , Tsai Kenneth Y. , Wermuth Peter J. , Overmiller Andrew M. , Mahoney Mỹ G.
Published: July 2020

Exosomes, or small extracellular vesicles (sEVs), serve as intercellular messengers with key roles in normal and pathological processes. Our previous work had demonstrated that Dsg2 expression in squamous cell carcinoma (SCC) cells enhanced both sEV secretion and loading of pro‐mitogenic cargo. In this study, using wild‐type Dsg2 and a mutant form that is unable to be palmitoylated (Dsg2cacs), we investigated the mechanism by which Dsg2 modulates SCC tumour development and progression through sEVs. We demonstrate that palmitoylation was required for Dsg2 to regulate sub‐cellular localisation of lipid raft and endosomal proteins necessary for sEV biogenesis. Pharmacological inhibition of the endosomal pathway abrogated Dsg2‐mediated sEV release. In murine xenograft models, Dsg2‐expressing cells generated larger xenograft tumours as compared to cells expressing GFP or Dsg2cacs. Co‐treatment with sEVs derived from Dsg2‐over‐expressing cells increased xenograft size. Cytokine profiling revealed, Dsg2 enhanced both soluble and sEV‐associated IL‐8 and miRNA profiling revealed, Dsg2 down‐regulated both cellular and sEV‐loaded miR‐146a. miR‐146a targets IRAK1, a serine‐threonine kinase involved in IL‐8 signalling. Treatment with a miR‐146a inhibitor up‐regulated both IRAK1 and IL‐8 expression. RNAseq analysis of HNSCC tumours revealed a correlation between Dsg2 and IL‐8. Finally, elevated IL‐8 plasma levels were detected in a subset of HNSCC patients who did not respond to immune checkpoint therapy, suggesting that these patients may benefit from prior anti‐IL‐8 treatment. In summary, these results suggest that intercellular communication through cell‐cell adhesion, cytokine release and secretion of EVs are coordinated, and critical for tumour growth and development, and may serve as potential prognostic markers to inform treatment options.

Abbreviations

Basal cell carcinomas, BCC; Betacellulin, BTC; 2‐bromopalmitate, 2‐Bromo; Cluster of differentiation, CD; Cytochrome c oxidase IV, COX IV; Desmoglein 2, Dsg2; Early endosome antigen 1, EEA1; Epidermal growth factor receptor substrate 15, EPS15; Extracellular vesicle, EV; Flotillin 1, Flot1; Glyceraldehyde‐3‐phosphate dehydrogenase, GAPH; Green fluorescent protein, GFP; Head and neck squamous cell carcinoma, HNSCC; Interleukin‐1 receptor‐associated kinase 1, IRAK1; Interleukin 8, IL‐8; Large EV, lEV; MicroRNA, miR; Palmitoylacyltransferase, PAT; Ras‐related protein 7 Rab7; Small EV, sEV; Squamous cell carcinoma, SCC; Tissue inhibitor of metalloproteinases, TIMP; Tumour microenvironment, TME
Demonstration of InP/InAsP/InP axial heterostructure nanowire array vertical LEDs
Authors: Akamatsu Tomoya , Tomioka Katsuhiro , Motohisa Junichi
Published: July 2020

Semiconductor nanowires (NWs), which have nanoscale footprints, enable us to realize various quantum structures with excellent position and size controllability, utilizing a wide range of materials for heterostructures. In addition, enhancing light extraction and controlling spontaneous emission by modifying their size and shape are possible. Thus, NWs are promising materials for nanoscale light sources applicable from visible to telecommunication bands. In this study, we grew InP/InAsP/InP axial heterostructure NWs, where the InAsP layer was embedded to serve as an active layer, by selective-area growth and demonstrated vertical NW array light-emitting diodes (LEDs) as a step towards realizing on-demand single photon sources. The NW array LEDs showed rectifying characteristics and electroluminescence originating from the embedded InAsP layer in the near-infrared region.
Application of artificial neural network and predictor screening method for downscaling climatic parameters
Authors: Rouzegari N , Nourani V , Molajou A
Published: July 2020

In this paper, artificial neural network (ANN) was used for downscaling the outputs of general circulation models (GCMs) to evaluate changes in precipitation and mean temperature for a future period in Urmia at the north-west of Iran. MIROC-ESM-CHEM from IPCC AR5 was selected as an acceptable model based on correlation coefficient (CC) values, which is calculated between precipitation of GCM models and precipitation data prepared by Urmia Meteorological Organization for 1951-2000. As a first step, the most important parameters of the MIROC-ESM-CHEM were selected before the downscaling process by ANN in the base period (1951-2000). Afterward, the future projections of precipitation and mean temperature during 2020-2060 were applied using ANN-based simulation according to the CC method. By comparing the results, the MIROC-ESM-CHEM showed a 2.01% increase under RCP4.5 and a 0.16% decrease under RCP8.5 in annual precipitation. Also, the temperature projection outputs showed the annual mean temperature would increase in the future period in this area, and it is likely to get warmer.
Hybrid analytical finite element method for dielectric response of PE/TiO2 nanodielectric materials
Authors: Zazoum Bouchaib
Published: July 2020

An accurate three-dimensional (3D) model was developed using hybrid analytical finite element method (H-FEM) for the simulation of frequency-domain dielectric response of low-density polyethylene (PE) filled with titanium dioxide (TiO2) nanoparticles. The input values of dielectric permittivity of nanoparticle and interphase were calculated analytically using the mixture model and adjusted by an optimization procedure. The effective permittivity of PE/TiO2 nanocomposites was then modelled by COMSOL Multiphysics. The model output results agreement with the experimental values indicate that the developed H-FEM 3D model is suitable for use in solving dielectric response problems of different nanodielectric materials in frequency domain. Furthermore, the simulation results also offer further understanding into the effect of the nanoparticle interphase on the final dielectric properties of the nanodielectric materials.