bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Associated With Actionable Gastrointestinal Panel Results in Hospitalized Children
Authors: Ho Erin C. , Cotter Jillian M. , Thomas Jacob , Birkholz Meghan , Dominguez Samuel R.
Published: November 2023

OBJECTIVES

There is uncertainty regarding which hospitalized patients with acute gastroenteritis (AGE) benefit from gastrointestinal panel (GIP) testing. Unnecessary testing may lead to increased costs, overdiagnosis, and overtreatment. In general, AGE management and outcomes are most impacted if an actionable (bacterial or parasitic) result is obtained. We aimed to assess which clinical reasons for ordering GIP testing (“order indications”) and patient factors were associated with actionable results.

METHODS

This is a cross-sectional study of pediatric patients hospitalized between 2015 and 2018 at a large pediatric health care system with diarrhea and a GIP performed. Multivariable regression analysis was used to determine associations between actionable GIP results and order indication, stool frequency, and demographics. Findings were evaluated in patients with complex chronic conditions (CCC) and non-CCC patients.

RESULTS

There were 1124 GIPs performed in 967 encounters. Non-CCC patients had more actionable results than CCC patients, and reasons for testing differed. Across both cohorts, age ≥1 year old was positively associated with actionable results. For non-CCC patients, actionable results were associated with “diarrhea with blood or pus” order indication and nonwinter season; international travel was associated with non-Clostridioides difficile bacteria and parasites. No order indications were associated with actionable results for CCC patients.

CONCLUSIONS

Patient factors and order indications that may help identify children hospitalized for AGE with actionable GIP results include older age (regardless of CCC status), as well as bloody stools and international travel in previously healthy children. Prospective validation of these findings could help improve diagnostic stewardship and decrease unnecessary testing.
Edición y reacción. Cómo la batalla cultural antiprogresista argentina se despliega (también) en los libros
Authors: Saferstein Ezequiel , Stefanoni Pablo
Published: November 2023

En los últimos años ha emergido en Argentina una constelación de lectores, editores y activistas políticos e intelectuales que buscan poner en pie una alternativa política y cultural a la derecha de Propuesta Republicana (PRO). La especificidad de este ecosistema es la emergencia de un dinámico núcleo autodenominado “libertario”, de base juvenil, y una particular recepción del estadounidense Murray Rothbard, cuyos postulados paleolibertarios funcionan como el articulador de una cultura de derecha sin los complejos de antaño. Javier Milei y Agustín Laje son dos figuras de estas derechas que han emergido en el debate público y político y se han constituido como referentes que lograron acceder de forma diferencial a instancias particulares de consagración. A partir del análisis de sus trayectorias autorales y editoriales nos proponemos reconstruir una dimensión de las derechas poco estudiada hasta el momento, teniendo en cuenta la relevancia del libro como artefacto tradicional de intervención intelectual, política y comercial. El análisis de los casos de Milei y Laje y de sus editores muestra cómo las nuevas derechas irrumpen en el espacio público desde las redes y desde libros de circulación masiva publicados por editoriales transnacionales que ponen su atención en este segmento en virtud de su rentabilidad. En este contexto, la “batalla cultural” que sus referentes presentan como emergente, antisistema e irreverente, se nutre y se complementa tanto de estructuras, dirigentes, prácticas y discursividades políticas de largo aliento como de la dinâmica comercial y espectacularizada de la industria cultural.
Composition of gut microbiota and its correlations with neurological, intestinal, cardiovascular and metabolic diseases
Authors: Sciuto Morena , Catanzaro Roberto
Published: November 2023

The intestinal microbiota is a microenvironment that has been the subject of studies for several decades. Over time, it has been reconsidered as a possible cofactor of multiple acute and chronic human diseases. In fact, alterations of the intestinal bacterial flora have been found in various neurological diseases. There are three modes of interaction between the intestinal microbiota and the gut-brain-axis: chemical signals, neural pathways and immune system. Even at the gastrointestinal level, the gut microbiota plays certainly an important role in the etiopathogenesis of chronic intestinal inflammatory diseases but also in irritable bowel syndrome. An important correlation has also been demonstrated with non-alcoholic fatty liver disease, as well as in other metabolic, cardiovascular and oncological diseases. Bacteria, viruses, fungi and various microorganisms that normally reside in our intestines can also be called into question as protective factors against these diseases. All this evidence leads researchers to consider the gut microbiota as a key element in the determination of aforementioned diseases. Therefore, it would be foreseeable in the future to associate the use of probiotics with the therapies used in the treatment of all these diseases. In this review we have condensed the main current knowledge regarding the link between the most frequent diseases and the gut microbiota.
Effect of microencapsulation conditions on phenolic compounds and antioxidant activity of propolis using double emulsion solvent evaporation approach
Authors: Amrane S. , Chaalal M. , Bouriche S. , Ydjedd S. , Rezgui F. , Ouchemoukh S.
Published: November 2023

The aim of this work was to microencapsulate propolis phenolic compounds using polycaprolactone as wall material by double emulsion solvent evaporation (w1/o/w2). Microencapsulation experiments were carried out by investigating the effect of sample/solvent ratio (10–100 mg mL−1), poly(ε-caprolactone) (PCL) concentrations (200–1,000 mg mL−1), poly(vinyl alcohol) (PVA) concentrations (0.5–2.5 g mL−1), and stirring speed (200–1,000 r.p.m.) on the microencapsulation efficiency of total phenolic content (TPC%) and antioxidant activity of propolis. The best microencapsulation conditions were selected according to the total phenolic amount and their antioxidant activity. Experimental results showed that all microencapsulation conditions had significant effects (P < 0.05) on total phenolic content and antioxidant activities. The best conditions were: 30 mg mL−1, 600 mg mL−1, 2 g mL−1, and 400 r.p.m. for sample/solvent ratio, PCL concentrations, PVA concentrations, and stirring speed, respectively, with values of 86.98 ± 0.03% for phenolic encapsulation efficiency, 53.81 ± 0.50% for free radical scavenging activity (DPPH), and 45,480 Trolox equivalent, mg TE/100 g dry weight for ferric reducing antioxidant power (FRAP). Under all encapsulation conditions, a significant positive correlation was observed between ferric reducing antioxidant power, free radical scavenging activity, and phenolic content.
First records of Clubiona hitchinsi Saaristo, 2002 on Ascension Island (Araneae, Clubionidae)
Authors: Sherwood Danniella , Marusik Yuri M. , Sharp Adam
Published: November 2023

Clubiona hitchinsi Saaristo, 2002, previously known from the Seychelles and French Polynesia, is newly recorded from Ascension Island, based on comparison of the Ascension specimens against two paratypes. The first detailed figures of the endogyne, based on a paratype, are provided. Characters in this species not found in European species of Clubiona Latreille, 1804 but found in the misplaced hystrix-group in Asia—namely the presence of a spine at the tip of the cymbium, retrolateral tibial apophysis with spine-like tip, and presence of a keel on the tegulum in the male, and copulatory ducts running on the posterior side in the genitalia of the female—are discussed.
Akumulasi Logam Berat Cu Dan Hg pada Mangrove Rhizopora mucronata di Pantai Timur Surabaya (Pamurbaya)
Authors: Mahmiah Mahmiah , Sa'adah Nor , Kisnarti Engki Andri , Millenia Fachrani Vebranti
Published: November 2023

Cemaran logam berat seperti Cu dan Hg di Pantai Timur Surabaya (Pamurbaya) dikhawatirkan memberikan dampak terhadap kualitas perairan. Mangrove yang tumbuh di Pamurbaya dapat digunakan sebagai indikator cemaran logam berat. Kemampuan mangrove dalam mengakumulasi logam berat ditunjukkan melalui nilai bioakumulasi (BAF), biokonsentrasi (BCF), dan translokasi faktor (TF). Salah satu mangrove yang terdapat di Pamurbaya adalah R.mucronata. Mangrove inimemiliki akar penyangga, selain fungsinya untuk membantu tegaknya pohon, akar jenis ini juga dapat menahan dan memantapkan sedimen tanah, sehingga mencegahtersebarnya bahan pencemar ke area yang lebih luas. Penelitian ini bertujuan untuk mengidentifikasi bioakumulasi cemaran logam berat Cu dan Hg pada mangrove R. mucronata, air, dan sedimen di  Pantai Timur Surabaya. Sampel penelitian diambil pada tiga lokasi melalui purposive sampling. Analisis logam berat Cu dan Hg  menggunakan metode Atomic Absorption Spectroscopy (AAS) dan parameter fisika-kimia oseanografi diukur secara in situ dengan pengulangan sebanyak 3 kali. Hasil penelitian menunjukkan kadar logam berat Cu pada air lebih tinggi dibandingkan sedimen berturut-turut Stasiun 1>Stasiun 2>Stasiun 3.  Hasil cemaran logam Hg pada mangrove R. mucronata, air dan sedimen menunjukkan nilai di bawah baku mutu dengan kisaran  0,0004< Hg<0,0006 ppm. Berdasarkan perhitungan nilai bioconcentration factor (BCF) dan translocation factor (TF), diketahui bahwa kemampuan mangrove R.mucronata sebagai tumbuhan excluder dan fitoekstraksi sehingga mampu mengurangi polutan logam berat dari lingkungan melalui proses penyerapan melalui akar dan translokasi menuju daun.
Trends in Emergency Department Visits Among People Under Age 65 Years by Insurance Status: United States, 2010-2021
Authors: Santo Loredana , Schappert Susan , Ashman Jill
Published: November 2023

This report provides health data from the National Center for Health Statistics.
A Portable Vision-Based Head Tracking Exergame Solution for Neck Rehabilitation
Authors: Quah Chee Kwang , Ng Jinhhao , Soon Benjamin
Published: November 2023

The current practice of neck rehabilitation is done through laser-pointing devices in a physical setup or Virtual Reality head-mounted devices, whereby the patient will control and navigate a laser beam to follow a specific pattern. These setups are cumbersome to the patient. We propose a portable computer vision-based marker-less head tracking exergame for neck rehabilitation. Our system retargets head postures to control a game object and considers neck mobility while incorporating movement modulation during posture overcompensation. This system would be tailored to the specific patient in the steps of automatic calibration and gameplay interaction. We used the head and body pose to calibrate the game scene dimensions, and the upper body joint angles to feedback the posture over-compensation in the form of gameplay variables augmentation. From our testing, it has shown that this is a viable exergame solution that could be adopted for neck exercise.
Cold weather concreting: provisions of codes and research advances
Authors: Yasien Ahmed , Bassuoni Mohamed T.
Published: November 2023

In cold regions, concrete practitioners face challenges in achieving the target performance criteria of concrete produced at low temperatures. When concrete temperature drops to −2.8°C, the hydration development of cementitious binders nominally ceases due to the freezing of mixing water, which results in hydraulic and osmotic pressures that exceed the tensile capacity of concrete, especially at early age (immature stage). Subsequently, the hardening and strength gain rates of concrete are adversely affected, resulting in insufficient microstructural development and irreversible deterioration, which makes concrete applications challenging under cold weather. Therefore, multiple investigations have been conducted to develop efficient approaches to overcome the challenges of placing concrete at low temperatures. The current paper synthesises code provisions in North America and Europe and state-of-the-art knowledge on cold weather concreting, in terms of mixture components as well as new inventions and methods of concrete curing and protection at low temperatures. Hence, it should provide informative guidance for the construction industry in cold regions to improve cold weather concreting practices.
Evaluación de la sustentabilidad en espacios rurales relacionados con el ecoturismo. estudio de caso en la selva Lacandona, Chiapas, México
Authors: Zarazúa José Alberto , Mazabel Davison , Moncayo Estrada Rodrigo , Rendón Medel Roberto
Published: November 2023

Esta investigación realiza una evaluación ex-post de la sustentabilidad en espacios rurales relacionados con el ecoturismo, centrada en un estudio comparativo de tres empresas enclavadas en la Reserva de la Biosfera Montes Azules (REBIMA) y una empresa más ubicada fuera de ella, todas en el municipio de Ocosingo, Chiapas, México. 75% de los entrevistados son hombres con edad promedio de 36 años, siete años de escolaridad y 1,9 hectáreas. La principal fuente de ingresos es el ecoturismo, que presenta una relación beneficio-costo venida a menos de 2,7 a 1,7, entre 2007 y 2011, respectivamente. La evidencia indica un desequilibrio en el acceso a subsidios, donde la pertenencia étnica desempeña un rol trascendental.
Acciones colectivas y recursos naturales en conflicto. Historia ambiental de luchas urbanas por agua y sierras en Tandil, Argentina
Authors: Guerrero Elsa Marcela , Wagner Lucrecia Soledad , Rodríguez Corina Iris , Sosa Beatriz Soledad
Published: November 2023

En el municipio de Tandil, diferentes expresiones socioambientales han tenido lugar a nivel local en las últimas décadas. Algunas de estas acciones responden a los efectos ambientales de ciertas actividades –la minería, la instalación de actividades contaminantes, la lucha urbana por el acceso a la tierra, al agua y a mejores condiciones ambientales, la problemática de los residuos sólidos urbanos e industriales y otros reclamos de justicia ambiental–. El presente trabajo discute desde una perspectiva teórica y mediante el análisis empírico de ciertos casos, las principales consideraciones epistemológicas asociadas a conceptos centrales que permiten entender y explicar el accionar social frente a la lucha ambiental. Por ello, interesa identificar ciertas problemáticas, describiendo los conflictos y las acciones colectivas de las luchas urbanas que reclaman mejoras en las condiciones ambientales a nivel local. El objetivo del presente trabajo es situar determinadas acciones colectivas en espacio y tiempo. Para ello se analizan cuatro casos de luchas urbanas suscitados por dos recursos naturales en pugna: el paisaje serrano y el recurso hídrico subterráneo.La selección del estudio de caso como método de investigación responde al carácter exploratorio del tema abordado. La inferencia lógica inductiva favorece la identificación de las categorías de análisis más propicias para su abordaje y pone en evidencia formas de organización, estrategias colectivas, y respuestas frente a los reclamos. Se emplean como técnicas de producción de conocimiento: la comparación, la observación documental –periódicos locales, sitios Web, archivos públicos y privados– y entrevistas a informantes calificados. En todos los casos bajo análisis las luchas se enmarcan en un contexto de crisis del Estado como proveedor de espacios de participación que favorecen la legitimación de nuevos espacios para el reclamo socioambiental. En particular cada caso presenta singularidades y generalidades que son posibles identificar y describir.
Estado de cosas inconstitucional en el caso del derecho a la alimentación de la población de La Guajira. Argumentos de la interpretación por parte de la Corte Constitucional de Colombia
Authors: Terreros Calle Fernando Carlos
Published: November 2023

En Colombia, de conformidad con el artículo 374, la Constitución Política podrá ser reformada por el Congreso mediante un acto legislativo, por una asamblea constituyente o por el pueblo mediante  referendo; sin embargo, la Corte Constitucional realiza actos de construcción jurídica cuya consecuencia es una mutación en la Constitución a través de la creación de normas implícitas como es el caso del estado de cosas inconstitucional, que da lugar al establecimiento de una nueva regla constitucional. Lejos de considerar que la interpretación del derecho es abiertamente discrecional o que, como lo manifiestan algunos autores (Suárez-Parra, 2007; López, 2011), la Corte Constitucional colombiana “legisle” o genere inseguridad jurídica, la creación de derecho en sede interpretativa es algo que no genera incompatibilidad con nuestra cultura jurídica, tal como lo indican Kelsen (1982), Tarello (2013) y Gómez (2018). La tesis planteada consiste en comprobar que los argumentos de la interpretación de la Corte corresponden con la teoría del escepticismo interpretativo del realismo genovés, aplicado a la figura de declaratoria de estado de cosas inconstitucional, cuyo fin es proteger los derechos fundamentales de la población Wayúu en La Guajira, especialmente el derecho a la alimentación en las sentencias de la Corte Constitucional de Colombia (T-302 de 2017, T-359 de 2018).
Emociones al enseñar Biología y enseñar a argumentar en Biología
Authors: Ruiz Ortega Francisco Javier , Rodas Rodriguez José Mauricio
Published: November 2023

Objetivo: identificar las emociones de futuros maestros al enseñar ciencias y enseñar a argumentar en clase de ciencias. Método: la investigación fue cualitativa con un alcance descriptivo-comprensivo, se realizó en un contexto de formación de maestros en una universidad pública colombiana. Se diseñó un estudio apoyado en la investigación-acción, analizar la información obtenida se realizó un análisis que combinó pruebas estadísticas con análisis de contenido. Resultados: se destaca, entre otros, que las emociones positivas como la felicidad, tranquilidad y satisfacción siguen manteniéndose y se consolidan al final del proceso; de igual manera, emerge una emoción epistémica relacionada con el aprendizaje y emociones negativas como el miedo y la preocupación desaparecen. Resultados alentadores que resaltan el proceso formativo orientado al reconocimiento, monitoreo y evaluación de las emociones frente al reto de enseñar a argumentar en clase de ciencias. Conclusiones: Al final del proceso, hubo reducción de emociones negativas cómo preocupación, nerviosismo, ansiedad y miedo. Algo diferente sucedió con las emociones positivas (cómo la felicidad) que incrementaron, al final, su aparición.
maternalismo en su laberinto. Políticas sociales y cuidado infantil en Argentina
Authors: Faur Eleonor
Published: November 2023

Objetivo. Analizar un conjunto de políticas sociales implementadas en la Argentina entre los años 2002 y 2014: el Plan Jefes y Jefas de Hogar Desocupados (PJJHD), el Programa Familias por la Inclusión Social (PF) y la Asignación Universal por Hijo (AUH). Se trata de políticas destinadas a sostener ingresos de los hogares más postergados, los cuales tienen hijos e hijas de hasta 18 años (19, en el caso del PF). Metodología. El artículo se apoya en documentos oficiales y en la revisión bibliográfica. Resultados y conclusiones. Se examinan los cambios y continuidades que se sucedieron entre estos tres programas desde una perspectiva de género; indagando en qué medida se facilita, mediante estos planes, la desmaternalización del cuidado; o si ―más bien― las políticas sociales perpetúan, con su accionar, una concepción maternalista.
Factores de la violencia intrafamiliar en el género femenino: análisis comparativo en tres ciudades de Colombia
Authors: Quintero Arango Luis Fernando , Ibagon Parra Diana Marcela , Álvarez Agudelo Carlos Eduardo
Published: November 2023

Objetivo. Identificar los factores generados por la violencia intrafamiliar en empleadas del sector textil confección, mayores de edad, de tres ciudades colombianas Medellín, Bogotá y Manizales. Metodología. La investigación fue de corte cualitativo, no experimental, descriptivo. Por medio de un análisis comparativo, tomando como muestra a 8 mujeres que participaron de manera voluntaria en una entrevista semiestructurada, se permitió generar unas categorías y subcategorías para luego realizar la codificación axial y establecer las relaciones sobre cada uno de los factores. Resultados y conclusiones. Dentro de los hallazgos encontrados aparece que de la violencia intrafamiliar se derivan situaciones familiares que conllevan diversos problemas en la estructura y el desarrollo familiar. En cada ciudad se logró unificar los factores que presentan relación directa con el objeto de estudio, el fenómeno de la violencia se presenta de forma muy uniforme en las tres ciudades y en cada una de las mujeres entrevistadas.
economía del cuidado: división social y sexual del trabajo no remunerado en Bogotá
Authors: Moreno Salamanca Natalia
Published: November 2023

Objetivo. El presente artículo hace una crítica al análisis económico dominante ya que ignora la producción y el trabajo realizado dentro de los hogares y su importancia en el funcionamiento de las sociedades. Metodología. Se utilizó como insumo la Encuesta Nacional del Uso del Tiempo (2012-2013) y las categorías teóricas de la economía feminista. Resultados y conclusión. Entre los hallazgos más importantes, se destaca que son las mujeres las principales proveedoras del bienestar ante la desigual distribución del trabajo no remunerado en los hogares y la deficitaria provisión de bienes y servicios del cuidado por parte del Estado y el sector privado. A su vez, el enfoque interseccional permitió revelar que son las adultas de menores ingresos y niveles educativos las que asumen la mayor carga. Los resultados evidencian la división sexual y social del trabajo doméstico y de cuidado no remunerado en los hogares bogotanos.
Prácticas de autocuidado y apoyo en mujeres transgénero residentes en Bogotá, durante sus procesos de tránsito de género
Authors: Lozano Beltrán Jenny Amparo
Published: November 2023

Objetivos. Conocer las principales prácticas de autocuidado y el apoyo recibido durante la transformación de algunas mujeres transgénero residentes en la ciudad de Bogotá D.C. Metodología. Se realizó una aproximación cualitativa a 5 mujeres transgénero y a 5 personas acompañantes del proceso, mediante entrevistas a profundidad, grabadas, transcritas y con información analizada en Excel por generación de variables a partir del discurso. Resultados y Conclusiones. Se encontraron prácticas de autocuidado en el discurso, adoptadas y creadas a partir de riesgos del proceso de transformación. Las mujeres refirieron ser víctimas de violencia por prejuicio de género al afirmar su identidad. El objetivo para tener la imagen deseada es superior al sometimiento de situaciones de riesgo, minimizado durante el tránsito de género hasta obtener la identidad deseada, alcanzando así un estado completo de bienestar. Son necesarios la garantía y el acceso a servicios de salud para la igualdad en los derechos de todas.
pautas de crianza: el sentido de las madres comunitarias del corregimiento de Mocondino
Authors: Moncayo Quiñónez Silvia Berenice Rocío
Published: November 2023

Objetivo. Presentar resultados de una investigación cualitativa, con enfoque descriptivo-comprensivo en torno al sentido que tienen las pautas de crianza desde la autoridad para las madres comunitarias del corregimiento de Mocondino-Nariño- Colombia y a partir de allí mostrarlas respecto a la formación que recibieron en su contexto familiar. Metodología. Se seleccionaron 9 madres comunitarias a las cuales se les aplicaron talleres reflexivos y guía de observación. Resultados y conclusiones. Se encontró que la autoridad que prima en los sistemas familiares creados es la democrática. Y que tanto el sistema familiar de origen como el contexto social influyen en la forma como perciben las madres comunitarias las pautas de crianza.
¿Por qué y para qué? Dos propuestas analíticas para los estudios de familia
Authors: Cicerchia Ricardo , Palacio Valencia María Cristina
Published: November 2023

Objetivo. Proponer desde un marco histórico y sociológico algunas razones e intenciones del tema de familia. Metodología. Construcción argumental entre dos voces expertas en este campo a la luz de dos preguntas metodológicas: el por qué y el para qué, mediante el desarrollo de una espiral hermenéutica. Resultados y conclusión. Los trazos argumentativos a partir de algunos historiadores y sociólogos clásicos y contemporáneos permiten evidenciar, por una parte, el por qué del tema y sus razones analíticas; y por otra, el para qué, desde la intención de marcar su panorama actual como un asunto público y político. Se concluye que la puesta en escena de esta conversación provoca direccionar busquedas investigativas y analíticas frente a los nuevos tiempos para las familias y las familias para los nuevos tiempos
Trabajo sexual y prepaguismo: una revisión documental con perspectiva de género
Authors: Planas González María Fernanda , Gutiérrez Velasco Alexandra
Published: November 2023

Objetivo. Este artículo presenta el resultado de un proceso de indagación documental tomando como referencia los estudios adelantados en un período de 10 años (2005-2015) sobre el fenómeno del prepaguismo y el trabajo sexual. Metodología. La indagación documental fue orientada a través de dos dominios: el primero identifica las teorías desde donde surgen las comprensiones de las ciencias sociales sobre el fenómeno de estudio, el segundo analiza las propuestas metodológicas y sus repercusiones en las perspectivas desarrolladas. Resultados y conclusiones. Se tomaron un total de 50 artículos publicados en revistas indexadas, repositorios institucionales y portales bibliográficos nacionales e internacionales, lo que permitió afirmar que existe un importante vacío teórico dentro de la comunidad científica en la comprensión del prepaguismo como fenómeno social, diferenciado del trabajo sexual convencional y la construcción social patriarcal sobre la mujer y sobre el trabajo sexual permea negativamente la configuración identitaria de quienes lo ejercen.
South African Controlled Foreign Companies' Rules and the Digital Economy
Authors: Sengwane Khodani
Published: November 2023

South Africa's controlled foreign company ("CFC") rules were enacted more than two decades ago before most of today's business models existed. These are anti-avoidance rules that ensure the South African taxation of profits diverted offshore by South African residents. In terms of the CFC rules, the profits of a non-resident company may also be subject to tax in South Africa at the hands of its South African resident shareholder if such non-resident company is considered to be a CFC. Advances in technology developments and the use of information communication and technology ("ICT") have given rise to what is referred to as the digital economy. The term refers to economic activities hinged on the use of ICT and the internet. Digitalisation has made it possible for a business to carry on economic activity without the need for a multitude of offices, staff, equipment, and other resources. As a result, new business models like Uber and Shien have emerged. This paper argues that the current South African CFC rules have not kept pace with these new business models and do not effectively regulate the new business models and the digital economy. This paper recommends that the CFC rules be updated to address the digital economy and new business models by amending the rules, incorporating the provisions of Electronic Communications and Transactions Act 25 of 2002 into the rules, using country-by-country reporting, and even considering implementing a regime alternative to CFC rules.
Öğrenme Analitiği Göstergelerini Raporlayan Açık Erişimli Çevrimiçi Bir Öğrenme Platformunun Kullanılabilirliğinin Değerlendirilmesi
Authors: GÜYER Tolga , SOMYÜREK Sibel , YURDUGÜL Halil , AYDIN Furkan , GÜLMEZ Ayşenur
Published: November 2023

Bu çalışmada Sürekli Veri Sağlama Sistemi adlı öğrenme analitiği göstergelerini raporlayan açık erişimli çevrimiçi bir öğrenme platformunun kullanılabilirliğinin değerlendirilmesi amaçlanmıştır. Geliştirilen ortamın kullanılabilirlik çalışması öğrenci, araştırmacı ve yönetici statülerinde olmak üzere toplam 45 kullanıcı katılımı ile gerçekleştirilmiştir. Araştırmacılar tarafından geliştirilen kullanılabilirlik veri toplama aracı ile elde edilen verilerin analizinde betimsel istatistikler ve içerik analizi kullanılmıştır. Kullanılabilirlik testi kapsamında sistemde yapılabilecek işlemlerle ilgili görevleri katılımcıların yapmaları istenmiştir. Bu esnada süreç araştırmacılar tarafından gözlemlenerek her bir görevin katılımcılar tarafından başarıyla gerçekleştirilip gerçekleştirilmediği, tamamlama süreleri ve hata sayıları kayıt altına alınmıştır. Ayrıca katılımcıların demografik bilgileri, katılımcıların likert tipi anket sorularına ve açık uçlu sorulara verdikleri yanıtlar da raporlanmıştır. Sonuç olarak SVSS sisteminin kullanılabilirliğinin yüksek olduğu ancak çeşitli düzetme ve iyileştirmelerin platformun kullanılabilirliğinin artması açısından gerekli olduğu belirlenmiştir. Ortaya çıkan kullanılabilirlik problemleri açıklanmış ve bu problemlerin düzeltilmesine yönelik öneriler sunulmuştur.
The prognostic role of the change in albumin-derived neutrophil-to-lymphocyte ratio during neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer
Authors: Pan Zhen , Wang Ye , Li Shoufeng , Cai Huajun , Guan Guoxian
Published: November 2023

The prognosis of patients with locally advanced rectal cancer (LARC) has improved with the adoption of a multidisciplinary treatment approach combining neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME). Developing real-time, sensitive biomarkers to monitor systemic changes during nCRT is of paramount importance. Although the association between albumin-derived neutrophil-to-lymphocyte ratio (Alb-dNLR) and prognosis in various cancers is established, its prognostic value in LARC patients undergoing nCRT is not well-studied. This study enrolled a cohort of 618 LARC patients, stratifying them into two groups according to their change in Alb-dNLR (∆Alb-dNLR) values, using an optimal cut-off point: a low ∆Alb-dNLR group (≤ 0.90) and a high ∆Alb-dNLR group (> 0.90). The prognostic significance of ∆Alb-dNLR was evaluated using a Cox proportional hazards model. The 5-year overall survival (OS) rates were 75.2% in the low ∆Alb-dNLR group (≤ 0.90) and 85.9% in the high ∆Alb-dNLR group (>0.90) (P < 0.001). The 5-year disease-free survival (DFS) rates were 71.2% and 80.6%, respectively (P = 0.016). Multivariate analyses demonstrated that both ∆Alb-dNLR and pre-Alb-dNLR were independent prognostic factors for OS (P ≤ 0.001), while ∆Alb-dNLR was demonstrated as an independent prognostic factor for DFS (P = 0.016). A predictive nomogram, incorporating the ∆Alb-dNLR subgroup, demonstrated enhanced performance (concordance index [C-index] of 0.720 for OS and 0.690 for DFS) compared to the pre-treatment Alb-dNLR subgroup (C-index of 0.700 for OS and of 0.680 for DFS). Therefore, ∆Alb-dNLR shows significant potential as a usable and prognostic biomarker for predicting OS and DFS in LARC patients undergoing nCRT.
ABDALA, a preventive vaccine against SARS-CoV-2, is safe in Chlorocebus aethiops sabaeus monkeys
Authors: Lizet Aldana , Iliana Sosa , Juan Carlos Polo , Mariby Gutierrez , Viviana Falcón , Avelina León , Rebeca Castillo , Pedro Puente , Nancy Esteves , Rodolfo Valdés , Marta Ayala , Miladys Limonta , Gerardo Guillén , Jorge Castro Velazco
Published: November 2023

Background: The ABDALA vaccine is a subunit vaccine developed for preventing SARS-CoV-2 infection and the progression of COVID-19 to severe forms, using as an active pharmaceutical ingredient a recombinant version of the SARS-CoV-2 spike protein receptor-binding domain (RBD) expressed in Pichia pastoris. The aim of the paper was to describe the safety profile of the ABDALA vaccine in monkeys (Cholorocebus aethiops sabaeus). For such aim, the vaccine was administered to the monkeys intramuscularly six times every 14 days, following the same scheme used in clinical trials done against COVID-19. Animals were allocated to four groups: Placebo, ABDALA Low-dose (50 µg per animal), ABDALA High-dose (100 µg per animal), and Reversion (100 µg per animal) to be submitted to a clinical, hematological and serum biochemical evaluation. Histopathological assessment of all tissues and organs was also conducted. Results: As the main results, all animals survived and negative effects were not detected during animal clinical evaluations. The body weight and rectal temperature exhibited no variations and hematological and serum biochemical parameters showed no alterations associated with ABDALA administration. Finally, the histopathological study confirmed the proliferation of spleen white pulp due to ABDALA administration. Conclusions: Therefore, results strongly suggest ABDALA does not cause toxic effects or damage in the organs of Chlorocebus aethiops sabaeus monkeys, indicating that it is a promising and safe novel vaccine to prevent SARS-CoV-2 infection in humans and the progression of COVID-19 to severe forms.
Enrichment and remediation of uranium by microorganisms: A review
Authors: Qiuhan Yu , Ouyang Cui
Published: November 2023

Uranium is a key raw material for the nuclear energy industry, the generation of nuclear energy is projected to double by 2040 to address the growing energy demands, which makes the uranium supply a matter of energy security. In addition, uranium is a heavy metal with both chemotoxicity and radiotoxicity, which seriously endangers human health and environmental safety. The growth in the utilization of uranium resources boosts the release of uranium into the environment. Therefore, the remediation of uranium contamination and recovery of uranium from a non-conventional approach is highly needed. Microorganism exhibits a high potential for immobilization of uranium. This review summarizes the ability of microorganisms to immobilize uranium from aqueous solutions and wastewater in terms of microbial species, performance, mechanism of enrichment and remediation, and applicable environment.
Human primary fibroblast culture v1
Authors: Chou Ching-Chieh , Frydman Judith
Published: November 2023

This is a protocol for human primary fibroblast culture.
RNAi Library screen v1
Authors: not provided e.warren
Published: November 2023

Protocol for screening a RNAi knockdown library in for behavioural and phenotypic effects in C. elegans
BEDEN EĞİTİMİ ÖĞRETMENLERİNİN COVID-19 SALGINI ÖNCESİ VE SÜRESİNCE ÖĞRENCİLERİNİN FİZİKSEL AKTİVİTELERİNİ TEŞVİK ETME DAVRANIŞLARI
Authors: ERTURAN Gökçe , DEMİRHAN Gıyasettin
Published: November 2023

COVID-19 salgınında beden eğitimi ve spor derslerinin uzaktan eğitimle yürütülmesi ve öğretmenlerin bu sürece hızla adapte olması gerekmiştir. Bu araştırmanın birinci amacı, salgın döneminde beden eğitimi öğretmenlerinin öğrencilerinin okul dışı fiziksel aktivitelerini teşvik etme uygulamalarını ve araçlarını belirlemede kişisel faktörlerin etkisini inceleyen bir yapısal eşitlik modeli test etmektir. Araştırmanın ikinci amacı, oluşturulan bu modelin COVID-19 salgını öncesinde ve salgın sırasında değişmezlik gösterip göstermediğini test etmektir. Çalışmada 129 kadın, 85 erkek olmak üzere toplam 214 beden eğitimi öğretmenine çevrimiçi öğretmen gruplarından ulaşılarak ölçek paketi çevrimiçi olarak uygulanmış ve her bir ölçek için öğretmenlerin salgın öncesinde ve salgın sırasında durumları için doldurmaları istenmiştir. Hipotez model, yapısal eşitlik modeli ile, salgın öncesi ve salgın sırasındaki durum için ayrı ayrı oluşturulmuştur. Salgın öncesi ve salgın sırasındaki parametreler arası değişimi test etmek için bu iki yapısal eşitlik modeli değişmezlik analizi ile test edilmiştir. Sonuçlar, öğretmenlerin öğrencilerinin fiziksel aktivitelerini teşvik etme uygulamalarının, biçimlerinin ve geri bildirimlerinin; eğitim teknolojilerini kullanma konusundaki öz-yeterlikleri, dijital teknolojileri kullanmaya yönelik tutumları, fiziksel aktiviteyi teşvik etmeye ilişkin öz-yeterlikleri ve fiziksel aktiviteyi teşvik etmeye ilişkin özerk motivasyonları tarafından pozitif açıklandığını ortaya koymuştur. Ayrıca salgın öncesi ve salgın sırası verileri ile elde edilen iki modelde tüm parametrelerin değişmezlik gösterdiği belirlenmiştir. Yani beden eğitimi öğretmenlerinin öğrencilerinin fiziksel aktivite davranışlarını teşvik etmeye yönelik davranışları ve davranışlarını açıklayan değişkenlerin düzey ve durumu, COVID-19 salgını sırasında, öncesindeki ile aynı kalmıştır. Beden eğitimi öğretmen adaylarına ve öğretmenlere, değişen teknolojiye uygun olarak, dijital teknolojilerin kullanımına yönelik eğitimler ile aktif ve sağlıklı hayat öğrenme alanına ilişkin öğretim tasarımı yapabilecekleri uygulamalı eğitimlerin verilmesi önerilebilir.
Effects of Hemp Fibers on Durability and Strength Properties of Concrete to be Used in Agricultural Buildings
Authors: Akıncı Ahmet Ozan , Karaman Sedat
Published: November 2023

Concrete is the most common construction material used worldwide. It is also commonly used in construction of agricultural buildings. With the rapid developments in technology, different building materials with superior properties are being researched in order to improve different properties of concrete and eliminate its disadvantaged aspects and to obtain lighter, insulated, more economical and useful construction materials. One of the applications to improve the negative properties of concrete with low tensile strength is to add various fibers into the concrete mixtures. Hemp stalks play an important role in recycling vegetable wastes. Therefore, it is highly significant to recycle or transform these materials. In this study, hemp fibers were supplemented into concrete mixtures in different ratios (1, 2.5 and 5%). Slump and unit weight tests were conducted on fresh samples and compressive strength, tensile strength, water absorption, freeze-thaw resistance, thermal conductivity and ultrasound pulse velocity tests were conducted on 28-day cured cube specimens. Slump values of the concrete samples varied between 3.50-12.00 cm, unit weights between 2262-2370 kg m-3 and water absorption values between 2.42-5.91%. Compared to the control concrete, maximum decrease in compressive strength (24.09%) was seen in 5% fiber-supplemented concrete samples (average 33.44 MPa). The highest splitting tensile strength (11.15%) was obtained from 1% fiber-supplemented samples. Compressive strength, specific gravity, ultrasound pulse velocity and thermal conductivity coefficients decreased, but tensile strengths and water absorption ratios increased with increasing hemp fiber ratios. As a result, by using hemp fibers in concrete production, a material with high tensile strength, suitable for cold climate conditions and low thermal conductivity was produced. Present mechanical and physical experiments revealed that hemp fiber-supplemented concretes, which are economical, sustainable, environment-friendly, recyclable and have low carbon emissions, could reliably be used in agricultural buildings and further improvements could contribute to the economy and reduce environmental pollution
It’s time to open your ears to world music: Commentary on Quan et al. (2022)
Authors: Hadavi Shafagh
Published: November 2023

This is a commentary on Quan et al. (2022) about their paper on world music open earedness and functional uses of music in relationship with psychological and sociocultural adaptations in student sojourners in Australia. The strengths of the paper, including the significance of cross-cultural music research and its applications for mental well-being, are discussed. Additionally, comparing responses through control groups and providing clear definitions of “novel and unfamiliar” musical excerpts for future replications are suggested in more detail in this commentary.
Resource Allocation in Massive Internet of Things-Edge Network with Optimal Path Planning and Scheduling
Authors: Barapatre Ajay K. , Sadiwala  Ritesh .
Published: November 2023

Although an Ultra Dense deployment is required for 5G services, it will be nearly impossible to achieve 60 service coverage with the dense deployments due to the even shorter transmission range. In light of 5G’s impressive technological advance, 5G and data centers are now capable of handling an increasing number of real-time and complicated computational tasks from Internet of Things (IoT) systems. This paper proposes an optimal mobile resource-sharing approach to confront this underlying limitation of 5G. In contrast to conventional algorithms, the designed optimal path planning and scheduling for mobile edge server (OPPSMES) is proposed that have the advantage of a synchronization among request being received and achieved lower delay and resource demand for as computing this allowed for the parallel processing of task and server in mobile condition. The OPPSMES includes two steps, i.e., path planning and optimal task scheduling, to improve efficiency. According to simulation outcomes, there is a significant increase in resource utilization and a decrease in average response time.
Types, accuracy, and efficacy of salivary biomarkers in periodontal diagnosis
Authors: Munshi Maha A. , Almozher Hanan A. , Alqahtani Fatimah A. , Youssef Mohamed M. , Almtere Abeer S. , Alsadoon Basel K. , Alotheem Lubna S. , Alhowirini Lama F. , Alotaibi Abdullah M. , Almutairi Abdullah A. , Assiri Ali H.
Published: November 2023

Periodontal diseases primarily occur due, to infections and inflammation that affect the gums and bone structures supporting the teeth. In the stage, known as gingivitis the gums may become swollen turn red and bleed easily. These health issues not impact health but also have broader implications for overall well-being, including tooth loss, discomfort, bad breath and an increased vulnerability, to chronic illnesses. The main objective of this review is to examine aspects pertaining to diseases encompassing clinical indications, methods, for diagnosis, available treatment choices, and preventive strategies. This research meticulously examines the types of these diseases, their stages, and their causes. It also discusses the approaches and criteria used to diagnose these conditions. Additionally, the paper provides an evaluation of treatment alternatives and strategic frameworks, for managing pathologies. This includes both surgical approaches, well as supportive therapies. The paper emphasizes the importance of measures. Maintaining oral health through consistent dental hygiene practices, regular dental checkups, and necessary lifestyle adjustments. In conclusion, while periodontal diseases pose challenges in practice they can be controlled and prevented through collaboration, between dental practitioners, dental hygienists, and active patient participation.
An overview of analgesic methodologies in orthodontics
Authors: Alqahtani Jamal M. , Alzaid Sarah A. , Aldhaban Omar A. , Alshdokhe Elaf D. , Alhellal Saleh A. , Alotaibi Yazeed R. , Alyami Hassan A. , Albalawi Salman S. , Alharthi Hassan M. , Hakami Maram M. , Alblowi Atheer A.
Published: November 2023

Orthodontic treatments aim to enhance teeth functionality and aesthetics through various methods like permanent, removable, and functional appliances. These interventions may involve teeth removal, surgical procedures for alignment, and even jaw position adjustments. The treatment typically starts with the placement of an orthodontic device, followed by periodic adjustments. One major concern for patients is the associated pain, directly linked to the applied force. Various devices influence pain intensity, with fixed devices being more painful. Pain peaks after certain adjustments, like placing separators, and is attributed to decreased blood flow due to brace-induced force. Pain is the primary reason some patients consider discontinuing treatment. Pain management involves both pharmacological and non-pharmacological approaches, including the promising but still under-researched low-level laser therapy (LLLT) and light emitting diodes (LEDs). Dietary changes also play a role during treatment due to pain. Proper nutrition and oral hygiene guidance are essential from orthodontists and general dentists.
Management and outcomes of apexification procedures in traumatized immature teeth
Authors: Alsharif Ainaa A. , Masaud Faisal S. , Binjabaan Khalid A. , Alwadai Naif M. , Maroof Faisal A. , Shabel Ibrahim A. , Daghriri Reham M. , Alsakr Reem M. , Aljeshi Alrbab M. , Alboori Ali J. , Mulla Nadin S.
Published: November 2023

The oral health of pediatric patients is a significant concern, with dental injuries being a common occurrence in this vulnerable population. Traumatic injuries to immature teeth, characterized by incomplete root development and open apices, present unique challenges that require specialized clinical management. Understanding the anatomy and developmental characteristics of immature teeth is crucial for effective management. Historically, apexification procedures relied on calcium hydroxide, but advancements in dental pulp biology led to regenerative endodontics, a transformative approach that preserves pulp vitality while promoting apical closure. Contemporary techniques include calcium hydroxide apexification, mineral trioxide aggregate (MTA) apexification, and regenerative endodontics, each with its advantages and considerations. Patient selection, radiographic assessment, choice of biocompatible materials, and post-operative care are key components of contemporary apexification protocols. Advanced imaging modalities like cone-beam computed tomography (CBCT) enhance diagnostic accuracy. Challenges in apexification procedures include infection control, the risk of root fractures, and dealing with resorption phenomena. Moreover, pediatric patients require special attention to address compliance and psychological factors. The long-term outcomes of apexification procedures extend beyond clinical and radiographic parameters and encompass growth and development as well as the quality of life of pediatric patients. Preservation of arch integrity, prevention of malocclusion, and maintaining oral health-related quality of life are vital considerations.
Models for determining the orientation of the solar battery of an observation spacecraft relative to the Sun during object survey and retargeting
Authors: Kurenkov V. I. , Pupkov E. A.
Published: November 2023

Simplified models and algorithms have been developed to estimate the current value of the angle between the normal to the plane of the solar panel and the sun vector at the time of object survey and during the reorientation of the Earth remote sensing spacecraft, taking into account the relative movement of observation objects in the field of view of the spacecraft. The models differ from the existing ones in that they do not require knowledge of the spacecraft control programs at pitch, roll and yaw angles at each moment of time of the process of its targeted functioning and re-targeting, Based on the obtained models, a software module that does not require large computing resources used in the simulation software package simulating targeted functioning of the space surveillance system has been developed, taking into account the long-term orbital motion of satellites, changes in the parameters of the orbit, the sun vector and other factors. The adequacy of the developed models was verified by visualizing the orbital motion of the spacecraft and its turns during re-targeting, as well as by comparing the simulation results with the results of analytical calculation for particular cases of the initial data. Examples of the implementation of software windows are given.