bluuebunny/crossref_metadata_2025 huggingface dataset:
Can Angiography Be Planned Based on Specific CT Signs of Ongoing Soft Tissue Bleeding in COVID-19 Patients Receiving Anticoagulants?
Authors: Polyaev A. Yu. , Tyagunov A. E. , Stradymov E. A.
Published: May 2024

Background. Anticoagulant therapy is recommended as basic medical treatment for COVID-19 patients with risk factors. At the same time, it is accompanied by a large number of hemorrhagic complications. Massive bleeding into abdominal and chest walls soft tissues as well as retroperitoneal space significantly worsens the course of underlying disease.

Objective: to assess the prognostic value of specific CT signs and their correlation with angiography data for the diagnosis of ongoing bleeding into soft tissues in COVID-19 patients.

Material and methods. A retrospective study was conducted, in which multi-slice computed tomography (MSCT) and angiography data were assessed and compared in 60 COVID-19 patients with spontaneous bleeding into chest and abdominal wall soft tissues as well as retroperitoneal space. A retrospective analysis of MSCT was carried out to identify symptoms specific to coagulopathic bleeding into soft tissues: contrast agent extravasation, hematocrit effect, and signal flare phenomenon.

Results. Contrast agent extravasation identified by MSCT was confirmed in 57 (95%) patients. More often (39 (68.4%) patients), extravasation was detected in MSCT arterial phase. In MSCT venous phase it was noted in 17 (29.8%) cases, in delayed phase – in 1 (1.8%) patient. With native MSCT, hematoma contained clots and fluid level (hematocrit effect) in 43 (71.7%) patients, in 17 (28.3%) patients it had a homogeneous structure. With intravenous contrast, in 39 (90.7%) cases with fluid level the signal flare phenomenon was established, which was more often detected in the arterial phase (33 (84.6%) cases). Extravasation was detected on angiography in 27 (45%) patients; they underwent therapeutic embolization. In another 15 patients preventive embolization was performed. When extravasation into hematoma without fluid level on MSCT (13 cases), extravasation on angiography was detected in 4 (30.8%) patients. In the presence of extravasation into hematoma with fluid level, but without signal flare phenomenon (4 patients) it was noted on angiography in 1 case. In the presence of all three signs (extravasation, hematocrit effect, and signal flare phenomenon – 39 patients), the incidence of extravasation on angiography was the highest – 56.4% (p = 0.028), and patients more often required therapeutic embolization.

Conclusion. Detection of extravasation, fluid level and signal flare phenomenon on MSCT in the structure of spontaneous hematoma in COVID-19 patients corresponded to ongoing bleeding and more often required embolization than in isolated extravasation.
Identification and Pathogenicity of Pestalotioid Species on Alpinia oxyphylla in Hainan Province, China
Authors: Cui Xiufen , Hao Zhigang , Chen Menghuai , Song Shuang , Zhang Jinan , Li Yingbin , Li Jianqiang , Liu Yixiang , Luo Laixin
Published: May 2024

Alpinia oxyphylla is a traditional Chinese medicinal plant, with a medicinal history of more than 1,700 years. Ring leaf blight (RLB) disease, caused by pestalotioid species, is an important disease of A. oxyphylla, seriously affecting the yield and quality of fruits. The causal agent of RLB disease has not been systematically identified and characterized so far. In this study, thirty-six pestalotioid strains were isolated from the leaves and stems of A. oxyphylla collected from 6 cities of Hainan province, China. Based on multi-locus phylogeny (ITS, tef-1α and tub2) and morphological characteristics analyses, seventeen species belonging to three genera (Neopestalotiopsis, Pestalotiopsis and Pseudopestalotiopsis) were identified and six new species (N. baotingensis, N. oblatespora, N. olivaceous, N. oxyphylla, N. wuzhishanensis and N. yongxunensis) were described. Pathogenicity tests revealed that strains of Neopestalotiopsis species caused more severe ring leaf blight on A. oxyphylla than strains of Pestalotiopsis and Pseudopestalotiopsis under wounded inoculation conditions.
Cervical Lymphadenopathy: Could it be prostate cancer?
Authors: Gupta Ekansh , Prabhudesai Madhumohan , Halarnakar Rajesh , Lawande Prashant
Published: May 2024

One of the most prevalent malignancies in males is prostate cancer, which most often metastasizes to the liver, thorax, bone, and local lymph nodes. The current case describes development of cervical lymphadenopathy; which remains a rather rare initial presentation, seen in <0.1% of the patients diagnosed with prostatic carcinoma. The current report describes a 55-year-old man with complaints of lower back pain and swelling on the left side of his neck for the previous two months. Physical examination revealed several swollen cervical lymph nodes that measured 2 cm, were nontender, firm, and adhered to the skin above. A poorly differentiated adenocarcinoma was found during cytological examination of the lymph nodes in the left lower cervical region. Findings from the ensuing Computed Tomography scan pointed to the possibility of spread prostatic cancer. PSA values were determined to be 364.762 ng/ml after additional analysis. The patient was then planned for hormone ablation therapy as per Institute protocol, in view of metastatic prostate cancer. The current report highlights the importance of timely detection of malignancies, particularly those such as Prostate cancer, that are slow growing and have well-established screening tools (such as PSA assays). Involvement of the cervical lymph nodes in prostate cancer, particularly for older individuals, is nearly always linked to extensive metastatic disease. As a result, it is a poor prognostic factor for prostate cancer patients, whose survival rates are markedly lower. Although hormone therapy has advanced significantly as the cornerstone of care for metastatic prostate cancer, the prognosis for these cases is still quite poor, especially when there has been distant lymph node metastases.
Ultrastructural and Morphological Observations of the External and Internal Structures of the Adult Midge Culicoides grisescens Edwards (Diptera: Ceratopogonidae)
Authors: Lu Xue , Zhang Yu Ling , Bao Shun Cai , Wang Zhuang Fei , Ma Jing , Zhou Nan Ling , Hou Xiao Hui
Published: May 2024

The external and internal structures of male and female adults of Culicoides grisescens Edwards, were examined with scanning electron microscope (SEM) and tissue section techniques. Specimens were collected from Qilian Mountain National Park in Qinghai Province, China. The ultrastructure and morphology of compound eyes, antenna, maxillary palpus, spermathecae, genitalia and other structural characteristics of both male and female adults of C. grisescens are described. Internal structures of the species are described, including histological sections of the digestive, nervous, respiratory, and reproductive systems. This paper provides visual and descriptive details for the systematic taxonomic study of Ceratopogonidae.
Serum Bilirubin Concentrations and Insulin Resistance in Advanced Maternal Age without Diabetes Mellitus
Authors: Han Man man , Zhang Yong
Published: May 2024

Aim: We estimated the correlation between serum bilirubin concentrations and insulin resistance in advanced maternal age without diabetes mellitus. Method: The cross-sectional study involved consecutive 50 women of advanced maternal age without diabetes mellitus, and insulin resistance (IR) was diagnosed according to the homeostatic model assessment insulin resistant (HOMA-IR) formula and the cut-off point was set to more than 2.5. Serum bilirubin and HOMA-IR were compared between the IR (+) and IR (-) groups. Results: We found that serum bilirubin levels in the IR subjects were significantly decreased compared to those without IR (p = 0.0252). Serum bilirubin concentrations were negatively correlated with the weight and the fasting insulin concentrations in all subjects (r=−0.282, p=0.047, r=-0.424, p=0.002). Additionally, serum bilirubin had a negatively correlation with HOMA-IR (r = -0.410, p = 0.003) in all subjects. The multiple linear regression analysis found that serum total bilirubin levels were independently correlated with HOMA-IR (beta = -0.392, p= 0.015) in these subjects. Conclusions: The study demonstrated that serum bilirubin concentrations had negatively correlation with insulin resistance in advanced pregnant women without diabetes mellitus, and decreased serum bilirubin may forebode increased gestational diabetes mellitus risk in our study population.
P2P Energy Exchange Architecture for Swarm Electrification-Driven PV Communities
Authors: Taouil Khaled , Aloulou Rahma , Bradai Salma , Gassara Amal , Kharrat Mohamed wajdi , Louati Badii , Giordani Michel
Published: May 2024

Swarm electrification-driven communities face significant challenges, including implementing advanced distributed control in areas with limited ICT access and establishing trust among villagers hesitant to grant access to their assets. This paper proposes a distributed DC microgrid architecture for P2P energy exchange in these communities, ensuring stability and effective exchange operation. By implementing a Blockchain marketplace specifically designed to suit the rural context, the proposed architecture ensures tracing of exchange transactions to fairly settle participants. Validation experiments demonstrate its efficacy in achieving peak shaving. It provides 11% of the requester's total demand from the community even while maintaining the constraint of reducing discharge-charge cycles to one per day, thereby preserving battery life. Additionally, the solution reduces prosumer production losses by 16% of the total PV production.
Surface Enhanced Raman Spectroscopy Combined With Multivariate Analysis for Fingerprinting Clinically Similar, Fibromyalgia and Long-COVID Syndromes
Authors: Nuguri Shreya Madhav , Hackshaw Kevin V. , Castellvi Silvia de Lamo , Wu Yalan , Gonzalez Celeste Matos , Goetzman Chelsea M. , Schultz Zachary D. , Yu Lianbo , Aziz Rija , Osuna Diaz Michelle , Sebastian Katherine , Brode W. Michael , Giusti M Monica , Rodriguez-Saona Luis
Published: May 2024

Fibromyalgia (FM) is a chronic central sensitivity syndrome characterized by augmented pain processing at diffuse body sites and presents as a multimorbid clinical condition. Long COVID (LC) is a heterogenous clinical syndrome that affects 10-20% of individuals following COVID-19 infection. FM and LC shares similarities with regards to the pain and other clinical symptoms experienced, thereby posing a challenge for accurate diagnosis. This research explores the feasibility of using surface enhanced Raman spectroscopy (SERS) combined with soft independent modelling of class analogies (SIMCA) to develop classification models differentiating LC and FM. Venous blood samples were collected using two supports, dried bloodspot cards (DBS, n= 48 FM and n= 46 LC) and volumetric absorptive micro sampling tips (VAMS, n= 39 FM and n= 39 LC). A semi-permeable membrane (10 kDa) was used to extract low molecular fraction (LMF) from the blood samples, and Raman spectra was acquired using SERS with gold nanoparticles (AuNPs). Soft Independent Modelling of Class Analogy (SIMCA) models developed with spectral data of blood samples collected in VAMS tips showed superior performance with a validation performance of 100% accuracy, sensitivity, and specificity achieving an excellent classification accuracy of 0.86 area under the curve (AUC). Amide groups, aromatic and acidic amino acids were responsible for the discrimination patterns among FM and LC syndromes, emphasizing the findings from our previous studies. Overall, our results demonstrate the ability of AuNPs SERS to identify unique metabolites that can be potentially used as spectral biomarkers to differentiate FM and LC.
Identification of SIBO subtypes along with nutritional status and diet as key elements of SIBO therapy
Authors: Wielgosz-Grochowska Justyna Paulina , Domański Nicole , Drywień Małgorzata Ewa
Published: May 2024

SIBO is a pathology of the small intestine and may predispose individuals to a range of nutritional deficiencies. Very little is known whether specific subtypes of SIBO, such as hydrogen-dominant (H+), methane-dominant (M+), or hydrogen/methane –dominant (H+/M+), impact nutritional status and dietary intake in SIBO patients. The aim of this study was to investigate possible correlations between biochemical parameters, dietary nutrient intake, and distinct SIBO subtypes. This observational study included 67 patients who were newly diagnosed with SIBO. Biochemical parameters and diet were studied utilizing laboratory tests and food records, respectively. The H+/M+ group was associated with low serum vitamin D (p<0.001), low serum ferritin (p=0.001) and low fiber intake (p=0.001). The M+ group was correlated with high serum folic acid (p=0.002) and low intakes of fiber (p=0.001) and lactose (p=0.002). The H+ group was associated with low lactose intake (p=0.027). These results suggest that the subtype of SIBO may have varying effects on dietary intake, leading to a range of deficiencies in the body. Conversely, specific dietary patterns may predispose to the development of a SIBO subtype. The assessment of nutritional status and diet, along with diagnosis of SIBO substype, are believed to be key components of SIBO therapy.
Digital Trio: Integration of BIM-EIR-IoT for Facilities Management of Mega Construction Projects
Authors: Abdelalim Ahmed Mohammed , Essawy Ahmed , A.AL Nasser AlJawharah , Shibeika Amna , Sherif Alaa
Published: May 2024

Facility Management (FM) has increasingly focused on using Building Information Modeling (BIM) in large-scale development projects. To successfully integrate BIM in the FM sector, cooperation among different participants involved in various project stages must be improved. The objective of this digital revolution in FM is to enhance the efficacy of planning, constructing, and managing assets, benefiting all parties involved. However, the utilization of BIM in FM is limited due to factors such as incomplete owner understanding, insufficient data accessibility, and stakeholders' unfamiliarity with BIM procedures and standardization. Although the FM industry acknowledges BIM's significance, achieving successful implementation remains challenging. Facility managers lack a clear understanding of BIM's benefits in expediting operations and cost efficiency and the necessary skills for efficient utilization. To address this constraint, it is essential to develop an Employee’s Information Requirement (EIR) at the outset of a project, serving as a strategic plan and providing a comprehensive vision for all parties involved, particularly large-scale projects. Two essential technologies that facilitate the transition towards building operations are BIM and the Internet of Things (IoT). Incorporating these technologies is crucial to reducing time, expenses, and operational challenges throughout any project. The aim of this research is to create a Digital-Trio workflow, as a new expression, by providing a methodology for using facility management with BIM through the integration of EIR and IoT, maximizes the benefit of stakeholders strategically and operationally. It also explores how the preparation of the EIR by communicating with all parties will definitely improve the design process, sustainability, efficiency, cost, and time for any project, especially megaprojects.
Enhanced Energy, Conversion Efficiency and Collimation of Protons Driven by High-Contrast and Ultra-Short Laser Pulses
Authors: Yao Weipeng , Lelièvre Ronan , Waltenspiel Tessa , Cohen Itamar , Allaoua Amokrane , Beck Arie , Cohen Erez , Davoine Xavier , D'Humieres Emmanuel , Ducasse Quentin , Filippov Eugene , Gautier Cort , Gremillet Laurent , Koseoglou Pavlos , Michaeli David , Papadopoulos Dimitrios , Pikuz Sergey , Pomerantz Ishay , Trompier Francois , Yuan Yuran , Mathieu Francois , Fuchs Julien
Published: May 2024

Progress in laser-driven proton acceleration requires increasing the proton maximum energy and laser-to-proton conversion efficiency, while reducing the divergence of the proton beam. However, achieving all these qualities simultaneously has proven challenging experimentally, the increase in beam energy often coming at the cost of beam quality. Numerical simulations suggest that coupling multi-PW laser pulses with ultrathin foils could offer a route for such simultaneous improvement. Yet experimental investigations have been limited by the scarcity of such lasers and the need for very stringent temporal contrast conditions to prevent premature target expansion before the pulse maximum. Here, combining the newly commissioned Apollon laser facility that delivers high-power ultrashort (∼24fs) pulses, with a double plasma mirror scheme to enhance its temporal contrast, we demonstrate the generation of up to 35 MeV protons with only 5 J of laser energy. This approach also achieves improved laser-to-proton energy conversion efficiency, reduced beam divergence, and optimized spatial beam profile. Therefore, despite the laser energy losses induced by the plasma mirror, the proton beams produced by this method are enhanced on all accounts compared to those obtained under standard conditions. Particle-in-cell simulations reveal that this improvement results from the intensified electrostatic field caused by a more compact hot-electron distribution.
Whey Protein Sodium-Caseinate as a Deliverable Vector for Tea Catechins: In vitro Optimization of Its Bioaccessibility, Bioavailability, and Bioactivity Mode of Actions
Authors: Korin Ali , Gouda Mostafa M , Youssef Mahmoud , Elsharkawy Eman , Albahia Amgad , Zhan Fuchao , Sobhy Remah , Li Bin
Published: May 2024

Epigallocatechin gallate (EGCG), the principal catechin in green tea, exhibits diverse therapeutic properties. However, its clinical efficacy is hindered by poor stability and low bioavailability. This study investigated solid particle-in-oil-in-water (S/O/W) emulsions stabilized by whey protein isolate (WPI) and sodium caseinate (NaCas) as carriers to enhance the bioavailability and intestinal absorption of EGCG. Molecular docking revealed binding interactions between EGCG and these macromolecules. The emulsions exhibited high encapsulation efficiencies and augmented EGCG bioaccessibility by 64% compared to free EGCG in a simulated gastrointestinal digestion model. EGCG-loaded emulsions demonstrated minimal cytotoxicity towards Caco-2 cells and facilitated EGCG transport across the intestinal epithelial layer without compromising tight junction integrity. Notably, EGCG-loaded emulsions protected Caco-2 cells against oxidative stress by suppressing intracellular reactive oxygen species generation. The results demonstrate the potential of WPI- and NaCas-stabilized S/O/W emulsions to enhance the bioavailability, intestinal absorption, and bioactivity of EGCG, expanding its applications in functional foods and nutraceuticals.
Use of Favipiravir in Covid-19 Patients: A Narrative Review
Authors: Ningrum Vitarani Dwi Ananda , Fitria Annisa , Hanur Fadiyah Ulfa
Published: May 2024

COVID-19 is an acute respiratory disease resulting from the infection of SARS-COV-2 viruses and causes high morbidity, which requires appropriate treatment targets. Favipiravir is an antiviral that selectively inhibits RNA-dependent RNA polymerase (RdRp) of virus. This review aimed to identify several studies that prove the effectiveness and safety of using Favipiravir for COVID-19 patients. The search method used the electronic media PubMed and ScienceDirect with the keywords "Efficacy", "Favipiravir", "Treatment", "Safety", SARS-COV-2", and "Favipiravir induced", accompanied by the addition of the affixes "AND" and "OR" and selection by the publication date starting December 2019. The literature search resulted in eight (8) published articles that met the exclusion and inclusion criteria. The results of the review showed that concurrent administration of Favipiravir and Lopinavir/Ritonavir or Chloroquine, with a dosage of Favipiravir of 3200 mg/day followed by 1200 mg/day each in 2 divided doses, was considered adequate for improving the clinical symptoms of COVID-19 patients with mild-moderate symptoms in early administration. Meanwhile, administering Favipiravir with anti-IL-6 Tocilizumab for patients with severe symptoms showed a fairly good effect. The most frequently reported ADE (adverse drug events) in the use of Favipiravir were hyperuricemia and elevated alanine aminotransferase (ALT) levels. This review concluded that the best clinical response to Favipiravir is shown in COVID-19 patients with mild-to-moderate early symptoms.
Caesalpinia sappan Reduce Fever with An Anti-inflammatory and Antioxidant Mechanism: A Review
Authors: Sasongko Heru , Hedianti Delia Putri , Safitri Listiyana Ika
Published: May 2024

Caesalpinia sappan L (Sappan wood) is an herbal plant that has long been trusted by the public as an herbal medicine for tuberculosis, diarrhea, dysentery, skin infections, anemia, and other diseases by utilizing the decoction of C.sappan. Sappan wood is an herbal plant widely used as a raw material for traditional medicinal products. Sappan wood has been reported to have substantial pharmacological effects in analgesic, antioxidant, antibacterial, anti-inflammatory, and anti-viral. Fever is a clinical manifestation of certain conditions or diseases characterized by increased body temperature above the normal range (36.5–37.5 °C). Many studies declare that antioxidant and anti-inflammatory activity in C.sappan reduces oxidative stress and pro-inflammatory cytokines. This literature review shows that the antioxidant and anti-inflammatory properties of C.sappan are linked to fever as a sign of illness. Literature review using the last ten years' Scopus, ScienceDirect, and Pubmed databases. There are as many as 20 journals regarding sappan wood's antioxidant and anti-inflammatory effects. Sappan wood has been shown to have an antioxidant effect by lowering reactive oxygen species levels via SOD, GPx, or CAT markers. It inhibits inflammation cytokines such as IL-1, IL-6, TNF-𝝰, and INF produced during fever. Sappan wood also has an anti-inflammatory effect by inhibiting PGE2 production when someone has a fever. The findings of our review state that C.sappan can be used to treat fever for both of these reasons. The use of C.sappan as a component in producing traditional health beverages has potential.
Emotional Intelligence and Culture Boost Accounting Understanding in Indonesia
Authors: Olivia Debby , Nurasik
Published: May 2024

This study investigates the impact of learning behavior, interest in learning, emotional intelligence, and culture on the understanding of financial accounting. Despite extensive research on factors influencing academic performance, there remains a gap in understanding how these specific variables affect accounting students' comprehension. The research employs a quantitative approach, analyzing data from 77 accounting students from the 2018 and 2019 cohorts at Muhammadiyah University of Sidoarjo. Data were collected via questionnaires distributed through Google Forms and analyzed using multiple regression analysis with SPSS. Results indicate that while learning behavior and interest in learning do not significantly influence financial accounting understanding, emotional intelligence and culture do. These findings suggest that emotional intelligence and cultural context play crucial roles in academic performance, highlighting the need for educational strategies that enhance these aspects to improve accounting education. Future research should explore the mechanisms through which emotional intelligence and culture affect learning outcomes in different educational settings.
Highlight:

Emotional intelligence and culture significantly influence accounting understanding.
Learning behavior and interest do not affect financial accounting comprehension.
Enhancing emotional intelligence and cultural awareness can improve academic performance.

Keywoard: Learning Behavior, Interest in Learning, Emotional Intelligence, Culture, Financial Accounting Understanding
Authentic leadership: A systematic review and research agenda
Authors: Polat Eray , Arıcı Hasan Evrim , Arasli Hüseyin
Published: May 2024

The aim of this study is multifaceted. First, we focus on providing a comprehensive overview of research on authentic leadership (AL), which has attracted substantial research interest in the last few years. Second, we outline the theoretical and nomological network of AL, highlighting antecedents, outcomes, moderators, and mediators. Third, we offer an elaborated future research agenda to enable advances in theory and empirics. We systematically reviewed 182 articles issued in the business management and psychology literature between 2005 and 2021. Interest in AL is growing, and 2020 is the golden year. Developed countries dominate the field. After a rigorous review, we offer a future research agenda with four key themes. The study highlights that AL is critical to the emergence and growth of valuable behaviours, attitudes and performance at individual, team and organisational levels. The study provides new research ideas and further conceptualization of AL. We also provide a comprehensive review of why managers should continue to practice AL, where the literature has been, and where it may be headed in the future.
The first recording of leaf blight disease Defla in Iraq
Authors: Jber Kamel S. , Habeb Khaled Abdul-Razaq
Published: May 2024

The results showed the spread of disease blight leaves caused by injury fungus Alternaria in different areas of cultivation in the city of Baghdad where he was recording the highest rate and the severity of the disease of 100% and 80%, respectively, in the Abu Ghraib area and the least of 20% and 12% respectively in the Amiriya district results showed test pathogenicity of the fungus pathogen emergence of symptoms of the disease superficial discoloration Authority of black paper when wound areas and yellowing of leaves about race as centrist and leaky latest country clear ????? on Central race after 48 hours ....
Totas serum sialic acid among enteric fever patients
Authors: Waheda N.F , Edan H.H , Abudi V.S
Published: May 2024

In this study serum total sailie acid concentration were tested as a scrological marker of discases activity to cvalute the result of the test in the diagonosis oe enteric fever(TSA) was measured in the serum od (50) patines with typhi fever(50)pa-tients
Charge Transfer studies of some oxadiazole derivatives with different
Authors: Alias M- , AL-Najjat N.
Published: May 2024

the physical paraneters of oxadizole derivaties as donor molecules have been measured the charge transfer and methanol as solvent have been estimated from the electonic spectra
A study of fermi hole for some atomic systems
Authors: Al-Bayati Khalil H. , Mohammed Kassem A. , Al-Baiti Khalid O
Published: May 2024

the electron correlation effect for inter-shell can be described by evaluating the fermi hole and partial fermi hole for Li atom comparing with Be+ and B+2 ions
identification of fungi and their toxins associated with imported rice grain to iraq
Authors: Al-Habeb Suzan A. , Abed Al-Razaq Khaled , Al-Obadi Khaled A
Published: May 2024

The study included the investigation of fungi ringed and inventory and Aflatoxins in rice and recorded average temperatures and humidity 22.75 degree Celsius and 13.2% respectively were obtained 1356 isolation innate possible diagnosis 15 species inherent in rice imported back to 8 races represented races b Fusarium , Cladosporium, Aspergillus and Alternaria
Treatment of polycyclic armoatic hydrocarbone in agriculture
Authors: Younis Muayd A.
Published: May 2024

Despite the multiple sources of polycyclic compounds in the agricultural environment, this study suggests that it is possible to adopt the events of plants and their associated microorganisms in the soil, such as mushrooms and bacteria in the decomposition of these compounds can also use harvested plants such as barley and alfalfa grown for animal feed
Develop Bactra system to determine Mutagens in the Environment, Food Second: use Hashr agents acridine orange
Authors: Al-Khfaji Zahra Mahmmod , Al-Azawi Ghaith Lotfi
Published: May 2024

Use Almtafr Alcderan orange, one of the factors Hashr Alttafaria to study Alatjabh isolates elected on the basis of specifications so that was a positive response with mutagen record and system consisting of three isolates used Alcderan orange graded concentrations and under specific Trov similar conditions Alttafar Pal NTG compared
Brucella antibod titres base line in the healthy individuals in haweja city
Authors: Al-Taei Safa M.T. , Al-Jebory Ibrahem S.
Published: May 2024

152 sera were collected from healthy individuals residing A;-Haweja City were tested for antibody titers for brucella antigens by slide agglutination test
the aspect of the radiation superposed on the soliton pulse propagated in single mode optical fiber
Authors: Al-Dabagh Samar.Y.
Published: May 2024

the first part of the research involves investigate the aspect of the radiation superposed on the one bright soliton pulse propagated on ideal single mode
the periodic coincidence points of continuius maps and lindemann's
Authors: Al-Taiy Ban Jaffar
Published: May 2024

this paper give a proof of known conditions for the existence of peridic conincidence points of continuius maps using lindemann theotem on transcendental numbers
The impact of concentrations of inorganic salts to compromise in rooting branches Genuine apples and apple architecture in vitro
Authors: Al-Hosainy Zainab Abdul-Jabar , Al-Jobori Abdul-Jaseem Mehsin Jaseem , Abdul-Hossen Moslem Abd Ali , Abedul-Wahab Sahar Naiem
Published: May 2024

Took apple branches Genuine and Architecture tissue cultured in vitro 3 cm long and planted in the middle of food MS that contains different concentrations of inorganic salts and of Mntmat free growth and incubated Transplanter to study their effect on rooting Aalavra
Family preference for the presence of cortical yellow
Authors: Khalaf Mohammed Ziedan , Abed Ahmed Gharbi , Al-Robaiyi Hothaifa M. , Akili Ryad Ali , Monshed Ali Katia
Published: May 2024

The population density of the insect on Alorat and fruits located in the lower part of the tree more than the middle part of the plant and insect in one place and demonstrates that there is a nest there were conducted laboratory and field studies on citrus Hsasahanwaa and the Alvdaúaa distribution of cortical insect yellow ....
monte carlo simulation in the kinetics and mileculare
Authors: Hussain Mahmoud sh. , Yang Yuliang
Published: May 2024

The primary focus of the study factor reverse polymerization styrene polymer kinetics and distribution weight Aljaia in Blma Aldhur free reverse The study was conducted wi Mamahakah and using the Monte Carlo method
synthesis and study of some mixed ligand complexes of caffeine
Authors: Al-azawi Shayma A.S.
Published: May 2024

I've been in this research preparation and diagnostic complexes mixed Kandat of Alcavaúan Alpiculan ion Althaaossianat with some metal ions has been reactive in ethanol solvent and distilled water by (1:1) and water complexes and lotions to the accounts of the metal in the complex
The impact of the lack of certain vitamins and minerals intake rate of hair loss in pregnant and breastfeeding women
Authors: Al-Deen Fatin Fakhar , Al-Ani Fatima F. Joma
Published: May 2024

The research aims to identify the rates of hair loss during pregnancy and lactation and its relation to the rates get some elements motivator urged through the results of the continued failure to meet the need of daily assessments of these elements, which led to the continuation of Hair Loss
5'-nucleoridase activity in sera from iraq children with leukemia
Authors: Al-Rubaee Eman A. , Al-Saffar Rokzan M. , Al-Arrji Sanad B
Published: May 2024

Enzyme activity were studied in the sera of children with leukemia than healthy children, where 31 cases were studied, including 21 cases of patients with acute lymphatic leukemia
About the construction of fuzzy inner product
Authors: Fadhel Fadhel S.
Published: May 2024

In this research for each positive integer integer and is accompanied by connecting that number with the number of Bashz Attabq result any two functions midwives to derive a positive integer so that there is a point
Most appropriate conditions of the binding of LH in Benign and Malignant
Authors: AL-Mudhaffar Sami A. , Nahab Hiba Itemad
Published: May 2024

Test method was developed radioimmunotherapy to appoint in two groups of patients infected with a uterine tumor Great conditions in tumor tissue benign and malignant Ddh teacher radioactive iodine isotope
Impact of replacing the old chicken and add soy protein in Alvezaawih qualities Barker beef
Authors: Al-Temimi Salem Saleh , Abdul-Huseen Saad , Al-Jomaily Sadia Mosa
Published: May 2024

The purpose of this study was to determine the impact of added soy protein humidifier concentration of different ratios of bovine Alberkr mix that was to bring the old chicken shop pure beef in five ratios
Elastic longitudinal electon catterting B from factors of
Authors: Adeeb Nadia M.
Published: May 2024

Electronic Alattarh been studied long flexible factors forming the nucleus of boron in the shell model framework multipolar been identified factors was introduced into the effects of polarization heart in the first place accounts
modification of polystyrene co butadiene
Authors: Pyriadi Thanun M. , Al-Majidi Suaad M.
Published: May 2024

During this research accomplish some chemical modifications on the Poly for new modified polymers with Kimaaaúah qualities, physical and unexpected new applications that the first of these chemical modifications that was completed is the introduction of a poly styrene butadiene swash and then this group
PPI-hotspotID: A Method for Detecting Protein-Protein Interaction Hot Spots from the Free Protein Structure
Authors: Chen Yao Chi , Sargsyan Karen , Wright Jon D , Chen Yu-Hsien , Huang Yi-Shuian , Lim Carmay
Published: May 2024

Experimental detection of residues critical for protein-protein interactions (PPI) is a time-consuming, costly, and labor-intensive process. Hence, high-throughput PPI-hot spot prediction methods have been developed, but they have been validated using relatively small datasets, which may compromise their predictive reliability. Here, we introduce PPI-hotspotID, a novel method for identifying PPI-hot spots using the free protein structure, and validated it on the largest collection of experimentally confirmed PPI-hot spots to date. We show that PPI-hotspotID outperformed FTMap and SPOTONE, the only available webservers for predicting PPI hotspots given free protein structures and sequences, respectively. When combined with the AlphaFold-Multimer-predicted interface residues, PPI-HotspotID, yielded better performance than either method alone. Furthermore, we experimentally verified the PPI-hot spots of eukaryotic elongation factor 2 predicted by PPI-hotspotID. Notably, PPI-hotspotID unveils PPI-hot spots that are not obvious from complex structures, which only reveal interface residues, thus overlooking PPI-hot spots in indirect contact with binding partners. Thus, PPI-hotspotID serves as a valuable tool for understanding the mechanisms of PPIs and facilitating the design of novel drugs targeting these interactions. A freely accessible web server is available at https://ppihotspotid.limlab.dnsalias.org/ and the source code for PPI-hotspotID at https://github.com/wrigjz/ppihotspotid/.
Supporting Teams with Designing for Dissemination and Sustainability: the Design, Development, and Usability of a Digital Interactive Platform
Authors: Kepper Maura , L'Hotta Allison , Shato Thembekile , Kwan Bethany M. , Glasgow Russell E. , Luke Douglas , Graham Andrea K. , Baumann Ana A. , Brownson Ross C. , Morse Brad
Published: May 2024

Background: The use of Designing for Dissemination and Sustainability (D4DS) principles and methods can support the development of research products (interventions, tools, findings) to match well with the needs and context of the intended audience and setting. D4DS principles and methods are not well-known or used during clinical and public health research; research teams would benefit from applying D4DS. This paper presents the development of a new digital platform for teams to learn and apply a D4DS process to their work.
Methods: A user-centered design (UCD) approach engaged users (n=14) and an expert panel (n=6) in an iterative design process from discovery to prototyping and testing. We led five design sessions using Zoom and Figma software over a 5-month period. Users (71% academics; 29% practitioners) participated in at least 2 sessions. Following design sessions, feedback from users were summarized and discussed to generate design decisions. A prototype was then built and heuristically tested with 11 users who were asked to complete multiple tasks within the platform while verbalizing their decision-making using the ‘think aloud’ procedure. The System Usability Scale (SUS) was administered at the end of each testing session. After refinements to the platform were made, usability was reassessed with 7 of 11 same users to examine changes.
Results: The interactive digital platform (the D4DS Planner) has two main components: 1) the Education Hub (e.g., searchable platform with literature, videos, websites) and 2) the Action Planner. The Action Planner includes 7 interactive steps that walk users through a set of activities to generate a downloadable D4DS action plan for their project. Participants reported that the prototype tool was moderately usable (SUS=66) but improved following refinements (SUS=71).
Conclusions: This is a first of its kind tool that supports research teams in learning about and explicitly applying D4DS to their work. The use of this publicly available tool may increase the adoption, impact, and sustainment of a wide range of research products. The use of UCD yielded a tool that is easy to use. The future use and impact of this tool will be evaluated, and the tool will continue to be refined and improved.
Evaluation of alternative prognostic thresholds for SP142 and 22C3 immunohistochemical PD-L1 expression in triple-negative breast cancer: results from a population-based cohort
Authors: Sigurjonsdottir Gudbjörg , De Marchi Tommaso , Ehinger Anna , Hartman Johan , Ullén Susann , Leandersson Karin , Bosch Ana , Staaf Johan , Killander Fredrika , Niméus Emma
Published: May 2024

Background
Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regards to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs) and TNBC molecular subtypes.
Material & Methods
We evaluated PD-L1 on a tissue microarray with the SP142 (immune cell (IC) score) and the 22C3 (combined positive score; CPS) IHC assays and evaluated abundance of TILs in a population-based cohort of 237 early-stage TNBC patients. Survival analysis was performed and RNA sequencing data employed for molecular profiling.
Results
As expected, PD-L1 positivity (IC ≥1% and/or CPS ≥1) was significantly associated with better prognosis compared to zero PD-L1 expression. Importantly however, also patients with intermediate expression (IC >0%, <1%; CPS >0, <1) showed a trend towards improved outcome. Tumors with intermediate PD-L1 IHC expression also had intermediate PD-L1 (CD274) gene expression (mRNA). Patients that were both low in TILs (<30%) and PD-L1 (IC <1%; CPS <1), tended to have the poorest prognosis.
PD-L1 positive tumors clustered significantly more often as Immunomodulatory-high and Basal-Like 1-high TNBC molecular subtypes and were enriched in immune response and cell cycle/proliferation signaling pathways. PD-L1-zero tumors on the other hand were enriched in cell growth, differentiation and metastatic potential pathways and clustered more prevalently as Luminal-Androgen-Receptor-high and Mesenchymal-high. PD-L1-intermediate tumors categorized with neither PD-L1-positive nor PD-L1-zero tumors on the hierarchical clustering level, consigning them as a unique subgroup.
Conclusion
With both SP142 and 22C3, we identified an intermediate IHC PD-L1 group within TNBCs that was supported on the molecular level. Any PD-L1 IHC expression, even though it is <1, tended to have positive prognostic impact. We suggest that the generally accepted threshold of PD-L1 IHC positivity in TNBC should be investigated further.
Trial Registration The Swedish Cancerome Analysis Network – Breast (SCAN-B) study was retrospectively registered 2nd Dec 2014 at ClinicalTrials.gov; ID NCT02306096.
Identification of anoikis-related tumor microenvironment characteristics and prognostic signature in ovarian cancer at bulk and single-cell levels
Authors: Tang Zhenye , Zhou Chenfei , Xu Yinyin , Huang Shuting , Liu Yueyang , Chen Jing , Jin Ping , Hu Jiemei , He Shanyang
Published: May 2024

Background
Ovarian cancer (OC) is one of the deadliest malignancies affecting women globally. Anoikis, a critical process that prevents the establishment of detached cells in non-native sites, is closely associated with cancer cell aggressiveness and poor patient outcomes. Despite its significance, research into the prognostic impact of anoikis-related genes (ARGs) in OC remains scant.
Methods
Single-cell RNA sequencing (scRNA-seq) was adopted to analyze anoikis activity using 41 ARGs across diverse cell types. The genomic and clinicopathological data was sourced from GSE26712 project (training cohort) and TCGA-OV project (independent validation set), respectively. Cox regression and the least absolute shrinkage and selection operator (LASSO) technique were utilized to develop an anoikis-related risk score (ANRS) for prognosis evaluation. Additionally, the correlation between ANRS and tumor microenvironment (TME) characteristics was explored. Functional experiments were conducted to elucidate the molecular role of the key gene AP1S2 in OC.
Results
Survival analyses in both cohorts categorized OC patients into two groups based on the median ANRS. The high-ANRS category exhibited evidently worse survival outcomes. Our findings highlighted a strong link between ARGs and TME characteristics, particularly the stromal components, at both bulk and single-cell transcriptomic levels. This underscores the complex interplay between cancer progression and the tumor-promoting stroma. Additionally, AP1S2 knockdown markedly reduced the proliferative and aggressive capabilities of OC cells.
Conclusion
The ANRS-derived prognostic tool offers substantial promise for advancing our understanding of OC progression and assisting gynecologists in developing effective treatment strategies for women suffering from this malignancy.
Poor Outcome in Infants with Shone’s Complex and Mitral Valve Stenosis is Associated with Ventricular Septal Defect, Pulmonary Vascular Disease and Residual Left Heart Obstruction
Authors: Curry Alexandra , Ashouri Judy , Moon-Grady Anita J. , Nawaytou Hythem
Published: May 2024

Objective
Infants born with multilevel left heart obstructive lesions (Shone’s complex), especially with mitral valve stenosis (MS), often require multiple surgeries and have a guarded prognosis. We aim to describe the characteristics of this cohort, with emphasis on echocardiographic and hemodynamic features associated with poor outcomes after biventricular repair.
Methods
Retrospective study of infants with Shone’s complex and MS between January 2016 – January 2021, who underwent biventricular surgical repair. Demographic data, cardiac catheterization and surgical reports were collected and longitudinal echocardiograms were re-analyzed. Poor outcomes were defined as death, heart transplantation or chronic mechanical ventilation.
Results
The cohort consisted of 12 patients, 8/12 with prenatal diagnosis, 11/12 male, 8/12 underwent cardiac catheterization and 7/12 had poor outcomes (5 deaths, 1 heart transplant, 1 chronic mechanical ventilation). Prenatal left to right foraminal flow (1/8) and retrograde flow in the distal aortic arch (3/8) were associated with poor outcome. Presence of a ventricular septal defect (5/12), more than mild residual mitral stenosis (5/12) or left ventricular outflow tract obstruction (3/8), and persistent pulmonary hypertension after repair (7/12) were also associated with poor outcomes. The prenatal and early postnatal size of the left heart structures and their growth were not associated with patient outcome.
Conclusion
Predictors of poor outcome in infants with multilevel left heart obstruction are related to the functional inability of the left heart to accept venous return and not to the size of the left heart structures. These findings may help family counselling and inform surgical management in the future.
Unveiling Spontaneous Renal Tubule-Like Structures from Human Adult Renal Progenitor Cell Spheroids Derived from Urine
Authors: Sallustio Fabio , Giannuzzi Francesca , Picerno Angela , Maiullari Silvia , Montenegro Francesca , Cicirelli Antonella , Stasi Alessandra , De Palma Giuseppe , Lorenzo Vito Di , Pertosa Giovanni Battista , Pontrelli Paola , Rossini Michele , Leo Vincenzo Di , Errede Mariella , Tamma Roberto , Ribatti Domenico , Gesualdo Loreto
Published: May 2024

The rapidly developing field of renal spheroids and organoids has emerged as a valuable tool for modeling nephrotoxicity, kidney disorders, and kidney development. However, existing studies have relied on intricate and sophisticated differentiation protocols to generate organoids and tubuloids, necessitating the external administration of multiple growth factors within precise timeframes. In our study, we demonstrated that human adult renal progenitor cells (ARPCs) isolated from urine of both healthy subjects or patients, have the capacity to form spheroids that naturally can form very long tubule-like structures. Importantly, the generation of these tubule-like formations is driven solely by ARPCs, without the need for the external use of chemokines or growth factors to artificially induce the process. These tubule-like structures exhibit expression of structural and functional renal tubule markers and bear, in some cases, striking structural similarities to various nephron regions, including the distal convoluted tubule, the loop of Henle, and proximal convoluted tubules. Furthermore, ARPC spheroids express markers typical of pluripotent cells, such as stage-specific embryonic antigen 4 (SSEA4), secrete elevated levels of renin, and showed angiogenic properties. Notably, ARPCs isolated from urine of patients with IgA nephropathy form spheroids capable of recapitulating the characteristic IgA1 deposition observed in this disease. These findings represent a significant advancement in the field, opening up new avenues for regenerative medicine in the study of kidney development, mechanisms underlying renal disorders, and the development of regenerative therapies for kidney-related ailments.