bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Structural, Thermal, and Hirshfeld Surface Analysis of In(III) Tris (N-Methyl-N-Phenyl Dithiocarbamate)
Authors: Ferjani Hela , Onwudiwe Damian C.
Published: September 2022

The reaction of ammonium N-methyl-N-phenyl dithiocarbamate with In3+ resulted in the In(III) tris (N-methyl-N-phenyldithiocarbamate) complex. The spectroscopic characterization of the complex was carried out using FTIR, 1H, and 13C NMR spectroscopy. Single-crystal X-ray diffraction analysis (SCXRD) revealed that the complex crystallizes in a triclinic system with a centrosymmetric P-1 space group. The stabilization of the structure was via weak hydrogen bonds and C-H···π contacts. The non-covalent interactions in the crystal network were identified using computational analysis based on SCXRD data, such as Hirshfeld surface analysis. The thermal decomposition behaviour of the complex was studied by thermogravimetric analysis, which showed a one-step decomposition to yield In2S3 at 380 °C.
The (Un)reasonable Effectiveness of Neural Network in Cherenkov Calorimetry
Authors: Akchurin Nural , Cowden Christopher , Damgov Jordan , Hussain Adil , Kunori Shuichi
Published: September 2022

We report a greater than factor of two improvement in the hadronic energy resolution of a simulated Cherenkov calorimeter by estimating the energy with machine learning over traditional techniques. The prompt signal formation and energy threshold properties of Cherenkov radiation provide identifiable features that machine learning techniques can exploit to produce a superior model for energy reconstruction. We simulated a quartz-fiber calorimeter via the GEANT4 framework to study the reconstruction techniques in single events. We compared the machine learning-based reconstruction performance to the traditional simple sum of signal and dual-readout techniques that use both Cherenkov and scintillation signals. We describe why this game-changing approach to Cherenkov hadron calorimetry excels and our plans for a dedicated beam test to validate these findings with a fast, radiation-hard hadron calorimeter prototype.
Energy Resolution Studies in Simulation for the IDEA Dual-Readout Calorimeter Prototype
Authors: Loeschcke Centeno Andreas
Published: September 2022

Precision measurements of Z, W, and H decays at the next generation of circular lepton colliders will require excellent energy resolution for both electromagnetic and hadronic showers. The resolution is limited by event-to-event fluctuations in the shower development, especially in the hadronic system. Compensating for this effect can greatly improve the achievable energy resolution. Furthermore, the resolution can benefit greatly from the use of particle-flow algorithms, which requires the calorimeters to have a high granularity. The approach of dual-readout calorimetry has emerged as a candidate to fulfil both of these requirements by allowing to reconstruct the fluctuations in the shower development event-by-event and offering a high transverse granularity. An important benchmark of such a calorimeter is the electromagnetic energy resolution; a prototype of the IDEA calorimeter has been built for use in testbeams. In parallel, a simulation of this prototype has been developed in Geant4 for a testbeam environment. Here, we outline how this simulation was used to study the electromagnetic energy resolution and conclude that a resolution of 14%/E is achievable.
Development of an Argon Light Source as a Calibration and Quality Control Device for Liquid Argon Light Detectors
Authors: Tosun Mehmet , Bilki Burak , Boran Fatma , Dolek Furkan , Sahbaz Kutlu Kagan
Published: September 2022

The majority of future large-scale neutrino and dark matter experiments are based on liquid argon detectors. Since liquid argon is also a very effective scintillator, these experiments also have light detection systems. The liquid argon scintillation wavelength of 127 nm is most commonly shifted to the visible range by special wavelength shifters or read out by the 127 nm sensitive photodetectors that are under development. The effective calibration and quality control of these active media is still a persisting problem. In order to respond to this need, we developed an argon light source which is based on plasma generation and light transfer across a MgF2 window. The light source was designed as a small, portable and easy-to-operate device to enable the acquisition of performance characteristics of several square meters of light detectors. Here, we report on the development of the light source and its performance characteristics.
A Distributed Model for Privacy Preserving V2I Communication with Strong Unframeability and Efficient Revocation
Authors: Kalogeropoulos Panayiotis , Papanikas Dimitris , Kotzanikolaou Panayiotis
Published: September 2022

Although Vehicle to Infrastructure (V2I) communications greatly improve the efficiency of early warning systems for car safety, communication privacy is an important concern. Although solutions exist in the literature for privacy preserving VANET communications, they usually require high trust assumptions for a single authority. In this paper we propose a distributed trust model for privacy preserving V2I communications. Trust is distributed among a certification authority that issues the vehicles’ credentials, and a signing authority that anonymously authenticates V2I messages in a zero knowledge manner. Anonymity is based on bilinear pairings and partially blind signatures. In addition, our system supports enhanced conditional privacy since both authorities and the relevant RSU need to collaborate to trace a message back to a vehicle, while efficient certificateless revocation is supported. Moreover, our scheme provides strong unframeability for honest vehicles. Even if all the entities collude, it is not possible to frame a honest vehicle, by tracing a forged message back to an honest vehicle. The proposed scheme concurrently achieves conditional privacy and strong unframeabilty for vehicles, without assuming a fully trusted authority. Our evaluation results show that the system allows RSUs to efficiently handle multiple messages per second, which suffices for real world implementations.
Experimental Investigation and Numerical Modeling of Two-Phase Flow Development and Flow-Induced Vibration of a Multi-Plane Subsea Jumper
Authors: Li Wenhua , Zhou Qing , Yin Guang , Ong Muk Chen , Li Gen , Han Fenghui
Published: September 2022

As an essential component in the offshore oil and gas industry, subsea jumpers are likely to encounter the cyclic-induced stresses caused by the alternating movement of gas plugs and liquid slugs while transporting a multiphase mixture. The present study investigates the gas-liquid flow and the induced vibration in a multi-plane jumper by adopting experimental and numerical techniques. The flow patterns at every characteristic section of a Z-shaped jumper with an inner diameter of 48 mm are experimentally investigated, including dispersed bubbly, slug, churn, wavy, stratified and annular flows. Displacement and pressure sensors are installed near each elbow to record the vibration and pressure response of the jumper. It is found that both pressure characteristics and vibration amplitudes are highly related to the gas content rate, mixing velocity, and gas and liquid superficial velocity. The one-way fluid–solid coupling numerical simulations are performed and validated against the experimental data in terms of the flow patterns and the induced vibrations at different gas–liquid velocities. The results reveal that both simulated flow patterns and vibration responses agree well with the experiments.
A Numerical Study on the Effects of Perforated and Imperforate Baffles on the Sloshing Pressure of a Rectangular Tank
Authors: Al-Yacouby Ahmad Mahamad , Ahmed Mostafa Mohamed
Published: September 2022

Sloshing has many industry applications, namely in offshore engineering, aerospace, ship building, and manufacturing. Sloshing simulation is essential to better understand the sloshing pattern and consequently to improve the tank design to reduce noise levels, stresses on the structure, and optimize the baffle configurations and arrangements. Thus, the aim of this study is to determine the effects of perforated (porous) and imperforate (solid) baffles on the sloshing pressure using ANSYS FLUENT software based on Volume of Fluid (VOF) method where a rectangular tank with 25% and 60% filling ratios was considered. In the first case, an unbaffled rectangular tank with 60% filling ratio was used for the validation purpose, while in the second case, a 25% filling ratio was investigated considering two scenarios, namely a unbaffled tank and a baffled tank case with perforated and imperforate baffles. The outcomes of the results indicate that perforated baffle can significantly reduce the sloshing pressure in the tank. The validation of the results also shows a good agreement with the published experimental results.
Stomatognathic System Changes in Obese Patients Undergoing Bariatric Surgery: A Systematic Review
Authors: Gualdrón-Bobadilla Gerson Fabián , Briceño-Martínez Anggie Paola , Caicedo-Téllez Víctor , Pérez-Reyes Ginna , Silva-Paredes Carlos , Ortiz-Benavides Rina , Bernal Mary Carlota , Rivera-Porras Diego , Bermúdez Valmore
Published: September 2022

Background: Obesity is a multifactorial chronic disease involving multiple organs, devices, and systems involving important changes in the stomatognathic system, such as in the orofacial muscles, temporomandibular joint, cheeks, nose, jaw, maxilla, oral cavity, lips, teeth, tongue, hard/soft palate, larynx, and pharynx. Patients with obesity indicated for bariatric surgery reportedly presented with abnormalities in the structures and function of the stomatognathic apparatus. This occurs through the accumulation of adipose tissue in the oral cavity and pharyngeal and laryngeal regions. Therefore, this systematic review aimed to elucidate the changes occurring in the stomatognathic system of patients with obesity after undergoing bariatric surgery. Method: Information was searched based on the equations developed with the descriptors obtained in DECS and MESH using the PRISMA methodology. Studies published between 2010 and October 2021 in databases including PubMed, ProQuest, Scielo, Dialnet, EBSCO, and Springer Link were considered. Results: Eighty articles met the inclusion criteria after evaluating the articles, thereby allowing for the determination of the morphophysiological correlation of the stomatognathic system with the population studied. At the morphological or structural level, changes were observed in the face, nose, cheeks, maxilla, jaw, lips, oral cavity, teeth, tongue, palate, temporomandibular joint, neck, muscles, head, shoulders, larynx, and pharynx. At the morphological level, the main changes occurred in, and the most information was obtained from, the labial structures, teeth, muscles, pharynx, and larynx. Physiological changes were in breathing, phonation, chewing, and swallowing, thereby revealing the imbalance in basic and vital functions. Conclusions: Analyzing the changes and structures of obese patients and candidates for bariatric surgery revealed that, in the preoperative period, the evidence is clear owing to the presence of a wide range of information. However, the information is more limited regarding the postoperative period; thus, further research focusing on characterization of the system postoperatively is warranted.
Safety and Family-Centered Care during Restriction of Hospital Visits due to COVID-19: The Experience of Family Members
Authors: Correia Tânia S. P. , Martins Maria Manuela F. P. S. , Barroso Fernando F. , Valentim Olga , Fonseca César , Lopes Manuel , Pinho Lara G.
Published: September 2022

Background: Person and Family Centered Care (PFCC) has demonstrated important contributions to health care outcomes. However, in response to the need for safety due to the pandemic COVID-19, measures were taken to restrict hospital visits. So, the aim of this study was to understand the healthcare experience of family members of patients hospitalized during the pandemic period regarding safety and person- and family-centered care. Methods: Qualitative interpretative study, conducted through semi-structured interviews with six family members of people hospitalized during the pandemic period. Content analysis was performed using Atlas.ti software version 22 (Berlin, Germany) and Bardin’s methodology. Results and Conclusions: Restrictions on hospital visits due to the pandemic of COVID-19 have led to a distancing of families from the hospital setting and influenced healthcare practice, making it difficult to involve families in the care process. In some cases, healthcare professionals made efforts to provide PFCC, attempting to minimize the impact of the visitation restriction. However, there were reported experiences of care delivery that did not consider social and psychological factors and did not place the person and family at the center of the care process, relying instead on the biomedical model. These practices left out important factors for the provision of safe care. It is crucial, even in pandemic settings, that healthcare professionals provide person- and family-centered care to the extent possible, promoting the safety of care. The family should be involved in the care of the person in the inpatient setting.
Too True to Be Good? The Non-Uniformity of Extraction from Adjunct Clauses in English
Authors: Nyvad Anne Mette , Müller Christiane , Christensen Ken Ramshøj
Published: September 2022

Adjunct clauses are traditionally assumed to be strong islands for extraction across languages. However, the universal island status of adjunct clauses has been challenged by studies showing that extraction is possible from finite adjunct clauses in the Mainland Scandinavian languages. The possibility of extraction in these languages appears to be affected by various factors, including the type of adjunct clause, the type of extraction dependency, and the presence of contextual facilitation. These findings call for a re-evaluation of the islandhood of adjunct clauses in English. We conducted an acceptability judgment study on relativization from three types of finite adjunct clauses in English (if-, when-, and because-clauses) in the presence of supporting context. We found that the three clause types showed rather non-uniform acceptability patterns: extraction from when- and because-clauses both yielded significantly lower ratings than extraction from if-clauses, which patterned with non-island that-clauses. Our results suggest that at least for relativization, if- and when-adjuncts are not invariably strong islands in English, and that extra-grammatical factors may be key in understanding island structures traditionally assumed to be purely syntactic in nature.
Magnetic Properties of a Solid Solution Fe1−xAgxCr2S4 (0 < x < 0.2)
Authors: Shabunina Galina G. , Busheva Elena V. , Vasilev Pavel N. , Efimov Nikolay N.
Published: September 2022

The magnetic properties of the Fe1−xAgxCr2S4 (0 < x < 0.2) solid solution were investigated in the temperature range 4–300 K in a DC field of 0.1 and 45 kOe. Fe1−xAgxCr2S4 is characterized by the transition temperature from the paramagnetic to the ferromagnetic state (Tc) and the irreversibility temperature (Tirr). The replacement of iron with silver ions in Fe1−xAgxCr2S4 leads to an increase in the Curie temperatures from 185 K (x = 0) to 216 K (x = 0.2) and Tcusp from 45 K (x = 0) to 125 K (x = 0.2). A section of the Fe1−xAgxCr2S4 magnetic phase diagram in the region under study has been constructed. The diagram reveals the following regions: paramagnetic, ferromagnetic, region of conditionally recurrent spin-glass (SG), and below 10 K a region associated with orbital ordering.
Evaluation of the Quality of Information Available on the Internet Regarding Chronic Ankle Instability
Authors: Yoon Sung-Joon , Kim Jun-Bum , Jung Ki-Jin , Chang Hee-Jun , Hong Yong-Cheol , Hong Chang-Hwa , Lee Byung-Ryul , Yeo Eui-Dong , Lee Hong-Seop , Won Sung-Hun , Ji Jae-Young , Lee Dhong-Won , Kim Woo-Jong
Published: September 2022

Background and objectives: Most Koreans obtain medical information from the Internet. Despite the vast amount of information available, there is a possibility that patients acquire false information or are dissatisfied. Chronic ankle instability (CAI) is one of the most common sports injuries that develops after an ankle sprain. Although the information available on the Internet related to CAI has been evaluated in other countries, such studies have not been conducted in Korea. Materials and Methods: The key term “chronic ankle instability” was searched on the three most commonly used search engines in Korea. The top 150 website results were classified into university hospital, private hospital, commercial, non-commercial, and unspecified websites by a single investigator. The websites were rated according to the quality of information using the DISCERN instrument, accuracy score, and exhaustivity score. Results: Of the 150 websites, 96 were included in the analysis. University and private hospital websites had significantly higher DISCERN, accuracy, and exhaustivity scores compared to the other websites. Conclusions: Accurate medical information is essential for improving patient satisfaction and treatment outcomes. The quality of websites should be improved to provide high-quality medical information to patients, which can be facilitated by doctors.
Specificity of the Associations between Indices of Cardiovascular Health with Health Literacy and Physical Literacy; A Cross-Sectional Study in Older Adolescents
Authors: Kesic Marijana Geets , Savicevic Anamarija Jurcev , Peric Mia , Gilic Barbara , Zenic Natasa
Published: September 2022

Background and Objectives: Cardiovascular health status (CVHS) is an important determinant of health, while it is theorized that health literacy (HL) and physical literacy (PL) could be directly related to CVHS. The aim of this study was to evaluate gender-specific associations between PL and HL and indices of CVHS in adolescence. Materials and Methods: The participants were 247 adolescents (177 females) from Split-Dalmatia county in Croatia who were tested on HL, PL, and CVHS (physical activity level (PAL) and lipid profile). The lipid profile included total cholesterol, triglycerides, high-density lipoproteins, non-high-density lipoprotein-cholesterol, and low-density lipoproteins. Gender-stratified multivariate cluster analysis (K-means clustering) was used to group participants into three homogenous groups on the basis of their HL and PL, while differences between clusters in CVHS were evidenced by analysis of the variance and consecutive post-hoc tests. Results: The lipid profile was better in girls with higher HL scores. Additionally, clusters consisting of participants with a better PL were characterized by higher PAL. We have found no evidence that HL is associated with PAL, while PL was not associated with the lipid profile. Conclusions: HL was specifically associated with direct indicators of health status (lipid profile) in girls, while PL was associated with PAL as a particular behavioral health indicator in both genders. The study highlights the necessity of including education of HL and PL in schools.
Pervaporation Polyvinyl Alcohol Membranes Modified with Zr-Based Metal Organic Frameworks for Isopropanol Dehydration
Authors: Kuzminova Anna , Dmitrenko Mariia , Zolotarev Andrey , Myznikov Danila , Selyutin Artem , Su Rongxin , Penkova Anastasia
Published: September 2022

Metal-organic frameworks (MOFs) are perceptive modifiers for the creation of mixed matrix membranes to improve the pervaporation performance of polymeric membranes. In this study, novel membranes based on polyvinyl alcohol (PVA) modified with Zr-MOFs (MIL-140A, MIL-140A-AcOH, and MIL-140A-AcOH-EDTA) particles were developed for enhanced pervaporation dehydration of isopropanol. Two membrane types (substrateless–freestanding; and formed on polyacrylonitrile support-composite) were prepared. The additional cross-linking of membranes with glutaraldehyde was carried out to circumvent membrane stability in pervaporation dehydration of diluted solutions. The synthesized Zr-MOFs were characterized by scanning electron microscopy, X-ray powder diffraction analysis, and specific surface area measurement. The structure and physicochemical properties of the developed membranes were investigated by Fourier-transform infrared spectroscopy, scanning electron and atomic force microscopies, thermogravimetric analysis, swelling experiments, and contact angle measurements. The PVA and PVA/Zr-MOFs membranes were evaluated in pervaporation dehydration of isopropanol in a wide concentration range. It was found that the composite cross-linked PVA membrane with 10 wt% MIL-140A had optimal pervaporation performance in the isopropanol dehydration (12–100 wt% water) at 22 °C: 0.15–1.33 kg/(m2h) permeation flux, 99.9 wt% water in the permeate, and is promising for the use in the industrial dehydration of alcohols.
Pepino (Solanum muricatum) Metabolic Profiles and Soil Nutrient Association Analysis in Three Growing Sites on the Loess Plateau of Northwestern China
Authors: Sun Zhu , Wang Lihui , Zhang Guangnan , Yang Shipeng , Zhong Qiwen
Published: September 2022

Different soil nutrients affect the accumulation characteristics of plant metabolites. To investigate the differences among the metabolites of pepino grown in greenhouses on the Loess Plateau in northwest China, we investigated the main soil nutrients and their correlation with metabolites. A total of 269 pepino metabolites were identified using UPLC-QTOF-MS to detect metabolites in fruits from three major pepino growing regions and analyze their differential distribution characteristics. A total of 99 of these substances differed among pepino fruits from the three areas, and the main classes of the differential metabolites were, in order of number: amino acids and derivatives, nucleotides and derivatives, organic acids, alkaloids, vitamins, saccharides and alcohols, phenolic acids, lipids and others. An environmental factor analysis identified soil nutrients as the most significant differentiator. Five soil nutrient indicators: TN (total nitrogen), TP (total phosphorus), AP (available phosphorus), AK (available potassium), and OM (organic matter), exhibited significant differences in three growing sites. Metabolite and soil nutrient association analysis using redundancy analysis (RDA) and the Mantel test indicated that TN and OM contributed to the accumulation of amino acids and derivatives, nucleotides and derivatives, and alkaloids while inhibiting organic acids, vitamins coagulation biosynthesis. Moreover, AP and TP were associated with the highest accumulation of saccharides and, alcohols, phenolic acids. Consequently, differences in soil nutrients were reflected in pepino metabolite variability. This study clarified the metabolite variability and the relationship between pepino and soil nutrients in the main planting areas of northwest China. It provides a theoretical basis for the subsequent development of Pepino’s nutritional value and cultivation management.
Escherichia coli Is Overtaking Group B Streptococcus in Early-Onset Neonatal Sepsis
Authors: Miselli Francesca , Cuoghi Costantini Riccardo , Creti Roberta , Sforza Francesca , Fanaro Silvia , Ciccia Matilde , Piccinini Giancarlo , Rizzo Vittoria , Pasini Lorena , Biasucci Giacomo , Pagano Rossella , Capretti Mariagrazia , China Mariachiara , Gambini Lucia , Pulvirenti Rita Maria , Dondi Arianna , Lanari Marcello , Pedna MariaFederica , Ambretti Simone , Lugli Licia , Bedetti Luca , Berardi Alberto
Published: September 2022

The widespread use of intrapartum antibiotic prophylaxis (IAP) to prevent group B streptococcus (GBS) early-onset sepsis (EOS) is changing the epidemiology of EOS. Italian prospective area-based surveillance data (from 1 January 2016 to 31 December 2020) were used, from which we identified 64 cases of culture-proven EOS (E. coli, n = 39; GBS, n = 25) among 159,898 live births (annual incidence rates of 0.24 and 0.16 per 1000, respectively). Approximately 10% of E. coli isolates were resistant to both gentamicin and ampicillin. Five neonates died; among them, four were born very pre-term (E. coli, n = 3; GBS, n = 1) and one was born full-term (E. coli, n = 1). After adjustment for gestational age, IAP-exposed neonates had ≥95% lower risk of death, as compared to IAP-unexposed neonates, both in the whole cohort (OR 0.04, 95% CI 0.00–0.70; p = 0.03) and in the E. coli EOS cohort (OR 0.05, 95% CI 0.00–0.88; p = 0.04). In multi-variable logistic regression analysis, IAP was inversely associated with severe disease (OR = 0.12, 95% CI 0.02–0.76; p = 0.03). E. coli is now the leading pathogen in neonatal EOS, and its incidence is close to that of GBS in full-term neonates. IAP reduces the risk of severe disease and death. Importantly, approximately 10% of E. coli isolates causing EOS were found to be resistant to typical first-line antibiotics.
DUSP4 Silencing Enhances the Sensitivity of Breast Cancer Cells to Doxorubicin through the Activation of the JNK/c-Jun Signalling Pathway
Authors: Al-Mutairi Mashael S. , Habashy Hany O.
Published: September 2022

Doxorubicin (Dox) has limited efficiency in breast cancer (BC) due to drug-acquired resistance. The epithelial–mesenchymal transition (EMT) plays a major role in the survival and drug resistance of cancer cells. It was suggested that the JNK pathway was implicated in the response to Dox by regulating EMT. DUSP4/or MKP-2 is a well-known regulator of the JNK pathway and was found to be highly expressed in BC. However, its functional significance is not yet fully understood. In the present study, the possible involvement of MKP-2 in Dox-induced EMT was investigated in breast cancer cells. Immunohistochemistry for tissues obtained from BC patients (n = 108) revealed 71.3% of tissues stained positively for MKP-2 while only 28.7% stained negatively. However, MKP-2 protein expression exhibited no significant relationship between BC prognostic factors, such as histological grade, histological type, hormonal status, and Ki-67 marker, its expression was significantly correlated with age 40 or below. In MDA-MB-231 cells, Dox-induced phosphorylation of JNK was sufficiently enhanced in MKP-2 silenced cells. This resulted in the attenuation of Dox-induced EMT, cell cycle arrest, and ultimately accelerated apoptosis. It was confirmed that the acquisition of Dox sensitivity by MKP-2 silencing largely depends on the stimulation of the JNK pathway. Indeed, results showed that overexpressing MKP-2 in non-tumorigenic MCF-12A cells dramatically inhibited Dox-induced JNK activation and, subsequently, cell death. The present study, to our knowledge, is the first to provide evidence for the potential role of MKP-2 in chemoresistance to Dox through modulating the JNK pathway and enhancing EMT.
Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases
Authors: Brahmaiah Dabbugoddu , Bhavani Anagani Kanaka Durga , Aparna Pasula , Kumar Nangunoori Sampath , Solhi Hélène , Le Guevel Rémy , Baratte Blandine , Robert Thomas , Ruchaud Sandrine , Bach Stéphane , Jadav Surender Singh , Reddy Chada Raji , Mosset Paul , Gouault Nicolas , Levoin Nicolas , Grée René
Published: September 2022

Three series of our lead CLK1 inhibitor DB18 have been designed, synthetized and tested against CLKs and DYRK1A kinases. Their cytotoxicity was subsequently measured on seven representative cancer cell lines. Guided by docking experiments, we focused on the less constrained part of the scaffold, and showed that drastically different substituents can be tolerated here. This work ended with the discovery of another promising derivative 12g, with IC50 = 0.004 µM in the inhibition of HsCLK1 and IC50 = 3.94 µM for the inhibition of HsDYRK1A. The SAR results are discussed in the light of extensive molecular modeling analyses. Finally, a kinome scan (463 human kinases) confirmed the outstanding selectivity of our lead compound DB18, suggesting that this scaffold is of prominent interest for selective CLK inhibitors. Altogether, these results pave the way for the development of inhibitors with novel selectivities in this family of kinases.
Experimental and Theoretical Studies on Optical Properties of Tetra(Imidazole) of Palladium (II) Phthalocyanine
Authors: Timoumi Abdelmajid , Dastan Davoud , Jamoussi Bassem , Essalah Khaled , Alsalmi Omar , Bouguila Noureddine , Abassi Henda , Chakroun Radhouane , Shi Zhicheng , Ţălu Ştefan
Published: September 2022

In this work, the optical properties of tetra(imidazole) of palladium phthalocyanine (PdPc(Im)4) in solution form and thin films on glass and fluorine-doped tin oxide (FTO) substrates were investigated via the thermal evaporation technique. The optical band gap was evaluated by ultraviolet–visible spectroscopy (UV-Vis). The energy band gap values were determined based on the Tauc graph. In addition, time-dependent density functional theory (TD-DFT) was used to simulate the UV-Vis absorption spectrum of the (PdPc(Im)4) molecule in the Dimethyl Sulfoxide (DMSO) solution phase. A good correlation was found between the DFT results and the experimental optical results. The band gap values between the experimental and DFT-simulated values are presented. The energy band gap of (PdPc(Im)4) obtained from the DFT calculations showed that it can be efficiently regulated. Frontier molecular orbitals and molecular electrostatic potentials were also proposed in this work. The surface study of the layers deposited on FTO was considered by atomic force microscopy (AFM) and scanning electron microscopy (SEM), and the results demonstrated good homogeneity covering the entire surface. The SEM image showed a homogeneous distribution of the grains with some spherical or rod-shaped structures and no agglomeration structures. This work rendered a strategy for regulating the energy band gap and compared the experimental observations obtained with theoretical studies, which provides a fundamental insight into the optical band for optoelectronic and thin-film solar cells.
Characterization and Differentiation of Fresh Orange Juice Variety Based on Conventional Physicochemical Parameters, Flavonoids, and Volatile Compounds Using Chemometrics
Authors: Vavoura Maria V. , Karabagias Ioannis K. , Kosma Ioanna S. , Badeka Anastasia V. , Kontominas Michael G.
Published: September 2022

The present study focused on the possibility of differentiating fresh-unprocessed orange juice according to botanical origin (variety), based on the use of conventional physico-chemical parameters, flavonoids, and volatile compounds, in combination with chemometrics. For this purpose, oranges from seven different varieties were collected during the harvest years of 2013–2014 and 2014–2015 from central and southern Greece. The physico-chemical parameters that were determined included: electrical conductivity, acidity, pH, and total soluble solids. The flavonoids: hesperidin, neohespseridin, quercetin, naringin, and naringenin were determined using high-performance liquid chromatography (HPLC-DAD). Finally, volatile compounds were determined using headspace solid-phase micro-extraction in combination with gas chromatography-mass spectrometry (HS-SPME/GC-MS). Statistical treatment of data by multivariate techniques showed that orange juice variety had a significant (p < 0.05) impact on the above analytical parameters. The classification rate for the differentiation of orange juice according to orange variety using multivariate analysis of variance (MANOVA) and linear discriminant analysis (LDA) was 89.3%, based on the cross-validation method.
Ellagic Acid Increases Stress Resistance via Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans
Authors: Bai Shuju , Yu Yaoru , An Lu , Wang Wenbo , Fu Xueqi , Chen Jing , Ma Junfeng
Published: September 2022

Ellagic acid is a natural polyphenol found in various fruits and vegetables. Numerous studies have shown that ellagic acid has beneficial effects on human health. In this study, we investigated the stress resistant action of ellagic acid in Caenorhabditis elegans (C. elegans). Notably, 50 μM ellagic acid prolonged the lifespan of C. elegans by 36.25%, 36.22%, 155.1%, and 79.07% under ultraviolet radiation stress, heat stress, oxidative stress, and Pseudomonas aeruginosa infection stress, respectively. Furthermore, the mechanism by which ellagic acid reduces the damage caused by ultraviolet radiation in C. elegans was explored. Ellagic acid could significantly induce the nucleus translocation of DAF-16 and, thereby, activate a series of target genes to resist ultraviolet radiation stress. Moreover, ellagic acid also significantly increased the expression of SOD-3 by 3.61 times and the activity of superoxide dismutase by 3.70 times to clean out harmful reactive oxygen species in C. elegans exposed to ultraviolet radiation stress. In both daf-16 mutant and daf-2; daf-16 double-mutant worms exposed to ultraviolet radiation, ellagic acid could no longer prolong their lifespan. These results indicate that ellagic acid plays an important role in resisting ultraviolet radiation stress in C. elegans, probably in an insulin/IGF-1 signaling pathway-dependent way.
Silver Catalyzed Site-Selective C(sp3)−H Bond Amination of Secondary over Primary C(sp3)−H Bonds
Authors: Jiao Luzhen , Teng Dawei , Wang Zixuan , Cao Guorui
Published: September 2022

Sulfamates are widespread in numerous pharmacologically active molecules. In this paper, Silver/Bathophenanthroline catalyzed the intramolecular selective amination of primary C(sp3)−H bonds and secondary C(sp3)−H bonds of sulfamate esters, to produce cyclic sulfamates in good yields and with a high site-selectivity. DFT calculations revealed that the interaction between sulfamates and L10 makes the molecule more firmly attached to the catalyst, benefiting the catalysis reaction. The in vitro anticancer activity of the final products was evaluated in MCF-7 breast cancer cells.
A Practical Peptide Synthesis Workflow Using Amino-Li-Resin
Authors: Akintayo Damilola Caleb , Manne Srinivasa Rao , de la Torre Beatriz G. , Li Yongfu , Albericio Fernando
Published: September 2022

Herein we report a practical approach for peptide synthesis using second-generation fibrous polyacrylamide resin (Li-resin, “Li” is coming from the name of its inventor, Yongfu Li). This resin with the corresponding handle was used for solid phase peptide synthesis (SPPS) using a fluorenylmethoxycarbonyl (Fmoc) approach. We reveal that the most appropriate mixing and filtration strategy when using amino-Li-resin in SPPS is via shaking and gravity filtration, instead of mechanical stirring and suction filtration used with other resins. The strategy was demonstrated with the SPPS of H-Tyr-Ile-Ile-Phe-Leu-NH2, which contains the difficult sequence Ile-Ile. The peptide was obtained with excellent purity and yield. We are confident that this strategy will be rapidly implemented by other peptide laboratories.
Field-Effect Transistor Based on 2D Microcrystalline MoS2 Film Grown by Sulfurization of Atomically Layer Deposited MoO3
Authors: Zabrosaev Ivan V. , Kozodaev Maxim G. , Romanov Roman I. , Chernikova Anna G. , Mishra Prabhash , Doroshina Natalia V. , Arsenin Aleksey V. , Volkov Valentyn S. , Koroleva Alexandra A. , Markeev Andrey M.
Published: September 2022

Atomically thin molybdenum disulfide (MoS2) is a promising channel material for next-generation thin-body field-effect transistors (FETs), which makes the development of methods allowing for its controllable synthesis over a large area an essential task. Currently, one of the cost-effective ways of its synthesis is the sulfurization of preliminary grown oxide- or metallic film. However, despite apparent progress in this field, the electronic quality of the obtained MoS2 is inferior to that of exfoliated samples, making the detailed investigation of the sulfurized films’ properties of great interest. In this work, we synthesized continuous MoS2 films with a thickness of ≈2.2 nm via the sulfurization of an atomic-layer-deposited MoO3 layer. X-ray photoelectron spectroscopy, transmission electron microscopy, and Raman spectroscopy indicated the appropriate chemical composition and microcrystalline structure of the obtained MoS2 films. The semiconductor quality of the synthesized films was confirmed by the fabrication of a field-effect transistor (FET) with an Ion/Ioff ratio of ≈40, which was limited primarily by the high contact resistance. The Schottky barrier height at the Au/MoS2 interface was found to be ≈1.2 eV indicating the necessity of careful contact engineering. Due to its simplicity and cost-effectiveness, such a technique of MoS2 synthesis still appears to be highly attractive for its applications in next-generation microelectronics. Therefore, further research of the electronic properties of films obtained via this technique is required.
2D MHD Mixed Convection in a Zigzag Trapezoidal Thermal Energy Storage System Using NEPCM
Authors: Abderrahmane Aissa , Younis Obai , Al-Khaleel Mohammad , Laidoudi Houssem , Akkurt Nevzat , Guedri Kamel , Marzouki Riadh
Published: September 2022

In a magnetic field, two-dimensional (2D) mixed convection is investigated within a zigzagged trapezoidal chamber. The lower side of the trapezoidal chamber is irregular, in particular, a zigzagged wall with different zigzag numbers N. The fluid particles move in the room due to the motion of the upper wall, while the porosity-enthalpy approach represents the melting process. The thermal parameters of the fluid are enhanced by what is called a nano-encapsulated phase change material (NEPCM) consisting of polyurethane as the shell and a nonadecane as the core, while water is used as the base fluid. In order to treat the governing equations, the well-known Galerkin finite element method (GFEM) is applied. In addition, the heat transfer (HT) irreversibility and the fluid friction (FF) irreversibility are compared in terms of the average Bejan number. The main results show that the melt band curve behaves parabolically at smaller values of Reynolds number (Re) and larger values of Hartmann number (Ha). Moreover, minimizing the wave number is better in order to obtain a higher heat transfer rate.
Average BER Performance Estimation of Relayed THz Links with Losses, Molecular Attenuation, Adverse Weather Conditions, Turbulence and Generalized Pointing Errors
Authors: Varotsos George K. , Aidinis Konstantinos , Nistazakis Hector E.
Published: September 2022

In recent years, the THz frequency band (0.3 THz–10 THz) has attracted an increasing research interest for the realization of emerging high-speed wireless communication links. Nevertheless, the propagation of THz signals through the atmospheric channel is primarily subjected to signal attenuation due to free space path loss (FSPL), water vapor, adverse weather conditions along with atmospheric turbulence-induced and misalignment-induced scintillations. Therefore, in this work, a multi-hop line-of-sight THz system that utilizes serially connected decode-and-forward relays is proposed to extend the total THz coverage distance under the presence of fog, rain or clear weather conditions, as well as water vapor, atmospheric turbulence, non-zero boresight pointing errors and FSPL. Under these circumstances, an average bit error rate (ABER) analysis is performed. In this context, novel closed-form ABER expressions are derived. Their analytical results demonstrate the influence of each of the above limiting factors as well as their joint impact on the ABER performance. Finally, the feasibility of extending the total THz link distance through multi-hop relaying configurations is also evaluated.
Foliar Application of Rhodopseudomonas palustris Enhances the Rice Crop Growth and Yield under Field Conditions
Authors: Yen Kuei Shan , Sundar Laurence Shiva , Chao Yun-Yang
Published: September 2022

Anthropogenic activities causing climate change and other environmental effects are lowering crop yield by deteriorating the growing environment for crops. Rice, a globally important cereal crop, is under production threat due to climate change and land degradation. This research aims to sustainably improve rice growth and yield by using Rhodopseudomonas palustris, a plant growth-promoting bacteria that has recently gained much attention in crop production. The experiment was set up in two fields, one as a control and the other as a PNSB-treated field. The foliar application of treatment was made fortnightly until the end of the vegetative stage. Data on the growth, yield, and antioxidant enzymes were collected weekly. The results of this experiment indicate no significant differences in the plant height, root volume, average grain per panicle, biological yield, grain fertility, and antioxidant enzyme activity between the PNSB-treated and untreated plants. However, a significant increase in the tiller number, leaf chlorophyll content and lodging resistance were noted with PNSB treatment. Likewise, PNSB-treatment significantly increased root length (25%), root dry weight (57%), productive tillers per plants (26%), average grains per plant (38%), grain yield (33%), 1000 grain weight (1.6%), and harvest index (41%). Hence, from this research, it can be concluded that foliar application of PNSB on rice crops under field conditions improves crop growth and yield, although it does not affect antioxidant enzyme activity.
The Fragility of Restoring Full Ordination for Tibetan Tsunmas (Nuns)
Authors: Price-Wallace Darcie M.
Published: September 2022

Drawing from interviews with tsunmas (Tib. btsun ma, nun) living and practicing in Geluk, Kagyu, and Sakya institutions in Bihar, Himachal Pradesh, Ladakh, and Uttarakhand, India, between March 2017 and February 2019, this case study foregrounds tsunmas’ heterogenous insights into the most ideal and acceptable ways for restoring gelongma (Tib. dge slong ma, Skt. bhikṣunī, fully ordained nun) vows. I argue that fragility, the quality of being breakable, underlies the history of gelongma vows in Tibet. Fragility, however, can also be generative. In this regard, fragility also signifies the possibility of restoring gelongma ordination for some tsunmas who are interested in receiving gelongma vows in India. This article examines Tibetan and Himalayan tsunmas’ perspectives on the possible ways of restoring gelongma ordination for women in the Tibetan Buddhist tradition. Since the lineage of gelongmas ceased in Tibet, some tsunmas see this fragility as prohibiting restoration of gelongma ordination unless there is a way to re-establish these vows through the Mūlasarvāstivāda Vinaya, the monastic code adopted in Tibet, whereas other tsunmas perceive this fragility as an opportunity for other possibilities for gelongma vow restoration through innovative ritual practices such as dual-Vinaya ordination.
Asylum, Racism, and the Structural Production of Sexual Violence against Racialised Women in Exile in Paris
Authors: Freedman Jane , Sahraoui Nina , Tyszler Elsa
Published: September 2022

The recent arrival of refugees from Ukraine has thrown into sharp focus the racialised colonial underpinnings of the French asylum and refugee system, as the open-door welcome afforded to Ukrainians, supposedly “closer” to the French population, highlights the rejection and marginalisation of “others” who seek refuge in the country. The current situation lays bare not only the “double standards” applied to refugees depending on their country of origin and race, but also the colonial foundations of the French asylum system as a whole. This might be seen as particularly significant in a country where even within academic research on asylum and refugees the racial and colonial foundations of the current system are rarely mentioned, and where the principle of Republican universalism has been consistently used to both hide and justify racialised and gendered forms of inequality and discrimination. In this contribution we wish to explore the ways in which the coloniality of the French asylum system works to deny exiled women access to welfare and social services, creating systems of racialised and gendered violence against them. We highlight the ways in which the State not only neglects these women, but actively contributes to violence through its racialised neo-liberal policies. The withdrawal of access to welfare and social services, including housing, welfare payments or health services, all form a part of this system of structural violence which leads to increasing levels of harm. Based on ethnographic research carried out in the Paris region, our article aims to emphasise that the structural production of gendered violence, particularly sexual violence against racialised exiled women, illustrates the coloniality of the asylum system and more broadly of the migration regime, which manifests itself in policies of exclusion, neglect and endangerment—including death.
Design and Implementation of an Anthropomorphic Robotic Arm Prosthesis
Authors: Yurova Valentina A. , Velikoborets Gleb , Vladyko Andrei
Published: September 2022

The development and manufacture of prosthetic limbs is one of the important tendencies of the development of medical techniques. Taking into account the development of modern electronic technology and automated systems and its mobility and compactness, the actual task is to create a prosthesis that will be close to a fully functioning human limb in its anthropomorphic properties and will be capable of reproducing its basic actions with a high accuracy. The paper analyzes the main directions in the development of a control system for electronic limb prostheses. The description and results of the practical implementation of a prototype of an anthropomorphic prosthetic arm and its control system are presented in the paper. We developed an anthropomorphic multi-finger artificial hand for utilization in robotic research and teaching applications. The designed robotic hand is a low-cost alternative to other known 3D printed robotic hands and has 21 degrees of freedom—4 degrees of freedom for each finger, 3 degrees for the thumb and 2 degrees responsible for the position of the robotic hand in space. The open-source mechanical design of the presented robotic arm has mass-dimensional and motor parameters close to the human hand, with the possibility of autonomous battery operation, the ability to connect different control systems, such as from a computer, an electroencephalograph, a touch glove.