bluuebunny/crossref_metadata_2025 huggingface dataset:
ОБЛІК ТРАНСАКЦІЙНИХ ВИТРАТ: БІБЛІОМЕТРИЧНИЙ АНАЛІЗ ТА ПЕРСПЕКТИВИ НАУКОВИХ ДОСЛІДЖЕНЬ
Authors: Гик Василь , Дефір Андрій
Published: February 2025

На сьогоднішній день трансакційні витрати викликають великий науковий інтерес серед учених-обліковців. Попри достатньо широке висвітлення проблемних питань обліку трансакційних витрат варто зазначити, що нами не було виявлено комплексних досліджень з використанням бібліометричного аналізу. Метою статті є визначення тенденцій розвитку наукових досліджень з обліку трансакційних витрат за допомогою бібліометричного аналізу. Дослідження здійснювалося на основі даних наукометричної бази Scopus із використанням програмних засобів R-Studio та VOSviwer. Для аналізу були відібрані публікації за період з 1994 по 2024 рр. За результатами аналізу встановлено збільшення загальної кількості публікацій, що підкреслює посилення уваги академічної спільноти до теми обліку трансакційних витрат. У результаті виявлено найбільш вживані ключові слова та представлено взаємозв’язки між ними. На основі проведеного аналізу за ключовими словами виявлено чотири кластери за тематикою обліку трансакційних витрат. Охарактеризовано наявні кластери наукових досліджень та оцінено перспективи розвитку подальших досліджень за темою обліку трансакційних витрат. За результатами проведеного дослідження вдалося оцінити інтерес науковців до проблематики обліку трансакційних витрат та можна сформувати такі висновки: по-перше, тематика обліку трансакційних витрат є актуальною у сучасних дослідженнях світового рівня; по-друге, цей напрямок у роботах українських учених на даний момент мало представлений у міжнародних наукових базах; по-третє, аналіз публікаційної активності шляхом використання спеціалізованих програм R-Studio та VOSviwer дозволив провести певні узагальнення великих дослідницьких масивів, розширити можливості для їхньої оцінки та подальшої дослідницької роботи в даному тематичному полі. Таким чином, отримані результати допоможуть науковцям та практикам краще усвідомити проблемні питання обліку трансакційних витрат та стануть основою для проведення подальших досліджень.
ПРЕЗЕНТАЦІЯ ЯК ІНСТРУМЕНТ ВІЗУАЛІЗАЦІЇ: ОСОБЛИВОСТІ ТА ЗНАЧЕННЯ В МАРКЕТИНГУ
Authors: Ромащенко Ольга , Крижко Ольга , Снітко Артем
Published: February 2025

У статті досліджено вплив основних інструментів візуалізації інформації на споживача, які підвищують якість комунікації та сприяють досягненню поставлених цілей, а також розроблено рекомендації по створенню презентацій, які ефективно доноситимуть інформацію, вражатимуть своєю візуальною привабливістю та відповідатимуть запитам аудиторії. Презентації є незамінним інструментом для візуалізації інформації в багатьох сферах життя, від освіти до бізнесу та науки. У статті виділено факти, як краще спілкуватись з аудиторією, досліджені етапи створення презентації, дотримання яких допоможе створити презентацію, яка ефективно доноситиме інформацію, вражатиме своєю візуальною привабливістю та відповідатиме запитам аудиторії. У сучасному інформаційному суспільстві презентації залишаються ключовим інструментом для ефективної передачі знань та ідей.
ОСОБЛИВОСТІ ФОРМУВАННЯ ІМІДЖУ ГРОМАДСЬКОЇ ОРГАНІЗАЦІЇ
Authors: Перевозова Ірина , Жарська Тетяна , Шпінь Вікторія
Published: February 2025

В умовах швидкої цифровізації, зростання інформаційної насиченості та підвищених вимог до прозорості, громадські організації (ГО) повинні активно працювати над формуванням впізнаваного та позитивного іміджу. Цей процес потребує комплексного підходу, що враховує соціальний контекст, специфіку діяльності ГО та динаміку змін у суспільних настроях. Створення довіри до організації, залучення нових партнерів і підвищення її впливу на сферу її діяльності, можливе лише за умови ефективного управління її іміджем. Однак, у багатьох ГО бракує системного підходу до формування власного образу в динамічному інформаційному просторі. Це створює ризики втрати довіри, зниження впливу та обмеження можливостей для партнерства. Водночас, традиційні маркетингові стратегії часто не відповідають соціальним реаліям, через що виникає потреба у розробці специфічних підходів, які поєднують елементи соціального маркетингу, брендингу та комунікації. Дослідження цієї теми дозволяє знайти шляхи, що допоможуть ГО посилити їхню роль у розв’язанні актуальних проблем і забезпечити довгострокову підтримку з боку громадськості.
No olvido, recuerdo. Crónicas universitarias desde la tercera edad (segundo certamen)
Authors: Moreno Castañeda Manuel , Zuno Arce Vicente , Medina Guerrero María del Consuelo , Pérez Rodríguez María Asunción , Solís Aguilar Maricela , Martínez Ramírez Armando , Rodríguez Duran Esther , Robles Uribe Joel , Hernández Castillo Luis , Carrillo Cázares Margarita , Chávez Gutiérrez María Rita , de la Mora Melo María Teresa , López Araujo Mirna , Salazar Ríos Nora Patricia , Martínez Venegas María Antonia , Garibaldi Padilla Roberto , Ruvalcaba Gómez Juan Manuel , Hernández Contreras Víctor Manuel , Ramírez Esparza José Carlos , Gómez Fregoso José de Jesús , Valle Galindo Ma. Cecilia , Pérez Arellano Ramón , Figueroa Rosales Ricardo , Sandoval Tovar Vicente , Rojo Diaz Gabriela , Van Messem María Inés Elena , Topete González Laura , Flores Cuevas Graciela
Published: February 2025

Relatos y entrevistas de experiencias estudiantiles, prácticas docentes, trabajos de campo, actividades artísticas y anécdotas contadas por egresados, académicos y trabajadores de la tercera edad. Vivencias y visiones de personal jubilado o aún en servicio en la UdeG que nos dan cuenta de la diversidad de vidas que han confluido en esta institución desde sus inicios.
A radioaktív hulladék cementezô technológia által használt cementtípusok azonosítása bórsavval kombinált féladiabatikus kalorimetriával
Authors: Baranyi Attila , Kopecskó Katalin
Published: February 2025

A Paksi Atomerőműben működő Radioaktív Hulladék Cementező Technológia segítségével a folyékony radioaktív hulladékokat cementkötésű anyagokkal keverik össze, majd a cementpépet acélhordókban elhelyezett szilárd radioaktív hulladékokat tartalmazó konténerekbe töltik. Az így elkészített ún. kompakt hulladékcsomagok minősítésük után már végleges tárolásra kerülhetnek.
A cementezési receptúra hulladéktípusonként változhat, valamint a keverékek érzékenyek lehetnek
a kötőanyagok minőségére, ezért az alapanyagokat minden szállítás alkalmával azonosítani kell. Mivel
a termékszabványok szerinti követelmények csak az adott cementtípusra vonatkozó alapvető jellemzők
ellenőrzésére szolgálnak és időigényesek, ezért az adott felhasználás szempontjából lényeges alkalmazástechnikai tulajdonságok ellenőrzéséhez szükség van egy egyszerű és gyors kiegészítő azonosítási
módszerre, a cementezési folyamat megkezdése előtt.
Tanulmányunkban, a Duna-Dráva Cement Kft. (DDC), a Holcim Magyarország Kft. (Holcim) és a Danucem Magyarország Kft. (Danucem) által gyártott különböző típusú cementeket vizsgáltuk. A méréseink
eredményeképpen a bórsavval kombinált fél-adiabatikus kalorimetrikus, és savas feltárással azonosítani
tudtuk a Radioaktív Hulladék Cementező Technológia működéséhez szükséges CEM I 42,5 N típusú cementet a DDC beremendi gyárából származó többi cementtípus között, valamint megvizsgáltuk a módszer
alkalmazhatóságát más, az építőiparban gyakran előforduló cementtípusokra is.
Kalocsa–Paks közötti új Duna-híd – 2. rész : A mederhíd szerkezete
Authors: Kisbán Sándor , Pusztai Pál
Published: February 2025

A cikkben bemutatjuk a mederhíd fő teherhordó szerkezeti elemeit. A leírásokban megadjuk azokat a
tervezési körülményeket, statikai okokat, amelyek a szerkezeti elemek kialakítását befolyásolták. Kitérünk
a tervezésnél alkalmazott programokra, a kivitelezés közbeni tapasztalatokra, illetve mérési eredményekre.
Perencanaan Supply Chain Management Pada Seneca Coffe Studio
Authors: SEMNASTI Dimas Hardiansyah
Published: February 2025

Perkembangan penjualan makanan dan minuman tumbuh dengan pesat. Salah satu minuman yang memiliki penjualan yang mengalami kenaikan yang besar adalah kopi. Dengan potensi berkembangannya penjualan kopi, maka untuk memiliki keunggulan dalam persaingan penjualan Seneca Coffee Studio perlu menerapakan Supply Chain Management.Tujuannya adalah untuk memahami proses pemilihan pemasok, perencanaan logistik, dan distribusi logistik yang diterapkan di Seneca Coffee Studio, serta bagaimana perusahaan dapat bersaing dalam industri kopi yang semakin ketat. penelitian mencakup analisis aktivitas manajemen rantai pasokan dari pengadaan bahan baku hingga penyampaian produk akhir kepada konsumen, serta tantangan yang dihadapi Khamal Nasution dalam menjalankan bisnis coffee shop. Hasil penelitian menunjukkan bahwa meningkatnya minat masyarakat terhadap kopi telah mendorong pertumbuhan bisnis coffee shop di Medan. Khamal Nasution, dengan motivasi merdeka finansial, berhasil melihat potensi keuntungan di sektor ini meskipun menghadapi tantangan persaingan yang ketat. Penerapan manajemen rantai pasokan yang efektif, termasuk pemilihan pemasok yang tepat dan perencanaan logistik, menjadi kunci keberhasilan usaha ini. Penelitian ini menyimpulkan bahwa manajemen rantai pasokan berperan penting dalam keberlangsungan bisnis kopi, seperti yang diterapkan di Seneca Coffee Studio. Keberhasilan dalam menjalankan manajemen rantai pasokan dapat meningkatkan daya saing dan efisiensi operasional, yang pada akhirnya mendukung pertumbuhan perusahaan di tengah persaingan yang semakin ketat
Strategi Pengembangan Digital Marketing Untuk Meningkatkan Pengunjung Didesa Wisata Wanawisata Sumber Biru Menggunakan Metode SWOT AHP Dan QSPM
Authors: SEMNASTI Lusi Apriliani , SEMNASTI Retno Indriartiningtias , SEMNASTI Indra Cahyadi
Published: February 2025

Jawa Timur memiliki potensi objek wisata yang sangat melimpah baik wisata alam maupun budaya. Salah satunya desa wisata yang ada di Wonosalam Kabupaten Jombang yaitu Desa Wisata Wanawisata Sumber Biru. Digital marketing yang digunakan di Desa Wisata Wanawisata Sumber Biru masih belum maksimal dalam penerapannya. Penelitian ini bertujuan untuk mengetahui faktor yang mempengaruhi digital marketing di Desa Wisata Wanawisata Sumber Biru dan memberikan formulasi strategi pengembangan digital marketing Desa Wisata Wanawisata Sumber Biru menggunakan metode analisis SWOT (Strengths, Weaknesses, Opportunities and Threats). Selain itu, metode Analytical Hierarchy Process (AHP) digunakan untuk menentukan bobot setiap faktor strategi dan Quantitative Strategi Planning Matrix (QSPM) digunakan untuk menentukan alternatif strategi terbaik. Hasil perhitungan QSPM diperoleh strategi 4 sebagai urutan pertama yaitu mendelegasikan karyawan untuk mengikuti seminar atau workshop digital marketing desa wisata wanawisata sumber biru dengan nilai TAS sebesar 14,98. Mendelegasikan karyawan untuk mengikuti pelatihan workshop atau seminar ini diharapkan dapat meningkatkan keahlian serta bermanfaat bagi pengelola dan karyawan Wanawisata Sumber Biru
Rancangan Kursi Untuk Pekerja UMKM Tempe Desa Jepara Wetan Dengan Pendekatan QFD
Authors: SEMNASTI Dandi Pratamaa , SEMNASTI Anastasia Febiyani , SEMNASTI Achmad Zaki Yamani
Published: February 2025

UMKM merupakan jumlah usaha terbanyak di Indonesia. UMKM Tempe yang berada di Desa Jepara Wetan saat ini belum dapat memenuhi kapasitas produksi. Berdasarkan proses produksi tempe terdapat beberapa faktor salah satu yang perlu diperhatikan adalah faktor berupa keluhaan kenyamanan pekerja. Keluhan yang sering dialami pekerja adalah musculoskeletal disorders (MSDs). Tujuan dari penelitian ini adalah untuk mendapatkan rancangan kursi dingklik yang diharapkan dapat mengurangi masalah MSDs. Pendekatan yang digunakan adalah dengan Quality Function Deployment (QFD). Data primer dan sekunder digunakan untuk mendapatkan hasil. Hasil dari penelitian adalah terdapat 2 alternatif pilihan yang kemudian disesuai dengan requirement list dari customer. Pemilihan desain alternatif didasarkan pada perhitungan metode weighted objective. Berdasarkan hasil pembobotan selisih antara alternatif 1 mendapatkan nilai 72.65 dan alternatif 2 bernilai 47.69, dikarenakan nilai penilaian bahan lebih tinggi digunakanlah desain 1 sebagai penentuan bahan pembuat kursi. Berdasarkan perhitungan diperoleh hasil berupa fitur yang dibutuhkan UMKM dalam pembuatan kursi dingklik sesuai dengan spesifikasi. Spesifikasi dari perancangan kursi ini adalah 600 x 465 x 490 mm dengan biaya pembuatan Rp 250,000-.
Problems of market transformation of the Russian economy
Authors:   FSBEI HE Udmurt State Agrarian University, Alekseeva Natalya A. , Gogolev Igor M. ,   FSBEI HE Udmurt State Agrarian University, Kislitsky Mikhail M. ,   Institute of Economics, Russian Academy of Sciences, Ryzhkova Olga I. ,   FSBEI HE Udmurt State Agrarian University
Published: February 2025

The Russian economy has an increasing geopolitical and economic impact on the economic trends that are taking shape in the world economy. In this she is helped by a rich resource base, high intellectual potential, leadership in the basic sectors of the economy, favorable geopolitical location, competent strategic policy of the authorities. The disadvantages in economic development in Russia are limited production capacities capable of producing competitive products, a low level of innovation activity and commercialization of innovations, a lack of some technological competencies, a shortage of workers and engineering personnel, and a low level of digitalization of management. Therefore, the issues of finding reserves for a more active structural transformation of the economy are becoming relevant. The aim of the study was to study modern theoretical approaches to the formation of structural economic policy, analyze the reproducible proportions of official statistics, identify problems and growth potential of key sectors of the economy through the use of macroeconomic policy tools. The objectives of the study are related to the study of new concepts of structural macroeconomic reproductive policy, the calculation of basic reproductive proportions over the past 5-8 years, the analysis of the dynamics of key indicators characterizing structural changes, and the development of recommendations for improving macroeconomic proportions in critical industries. The scientific novelty of the study lies in the assessment of the progressiveness of structural transformations in the Russian economy. The practical significance of the study lies in the ability to predict further structural transformations based on the identified trends and reserves of output growth in promising industries.
Imperatives of actualization and clarification of the interpretation of the mobilization economy essence
Authors:   Market Economy Institute of RAS, Salikhov Boris V. ,   Expert and Analytical Center, Salikhova Irina S. ,   Market Economy Institute of RAS,   Moscow University named after S.Y. Witte
Published: February 2025

The article is devoted to the verification of the need to transfer the modern domestic economy to the mobilization rails of socio-economic development. The key imperatives-factors of actualization of the accelerated development of mobilization relations in our country have been identified, among which a special place is occupied by the current consequences of a special military operation (SVO), as well as new threats caused by both the aggravation of inter-civilizational contradictions and the requirements of the sixth technological order. A logical and epistemological analysis is proposed and the disadvantages of existing interpretations of the mobilization economy are substantiated. It is shown that a monodisciplinarity approach to the problem, as well as the lack of a proper "human dimension" in understanding this economy, hardly contribute to increasing the level of both research and relevant scientific and practical effectiveness. Based on the analysis of the relationship between the phenomena of "mobilization" and "economy", an approximate interpretation of the essence of the mobilization economy has been developed, which means an economy, a system of relations within which allows for timely actualization, as well as the required combination and highly effective use of available limited resources and factors of production to achieve urgent existential socio-economic and other goals of the individual, societies and states.
Expression of BRCA1 mRNA in cancerous and non-cancerous breast tissue of Bangladeshi females attending a tertiary care hospital
Authors: Nishat Latifa , Rahman Sufi Hannan Zulfiqar , Arjuman Farida , Yesmin Zinnat Ara , Nahar Lutfun , Laboni Umma Habiba , Amee Samira Sultana , Afroze Farzana
Published: February 2025

Background: Dysfunctions of the BRCA1 (BReast CAncer gene1) gene are reported in cancerous and non-cancerous breast lesions. BRCA1 mRNA expression is variable in breast cancer, while this information is still inadequate in non-cancerous breast disorders. This study aimed to measure BRCA1 mRNA expression in cancerous and non-cancerous breast tissue of Bangladeshi females.
Methods: The cross-sectional study was conducted on 50 breast cancer and 19 non-cancerous females. RNA was extracted from formalin-fixed paraffin-embedded breast tissue. Real-time RT-PCR was done for measuring BRCA1 mRNA. BRCA1 mRNA expressions in cancerous and non-cancerous breast tissue were compared and analysed.
Results: BRCA1 mRNA expression was reduced or absent in most of the cancerous and non-cancerous (consisting of fibroadenoma, fibrocystic disease, ductal hyperplasia and normal breast tissue) breast tissue. Expression of BRCA1 in breast cancer and fibroadenoma was almost similar statistically. All cancers were invasive ductal carcinoma and of grade II, and most of them were sporadic (86%). BRCA1 expression was not associated with reproductive or cancer-related characteristics except consanguinity of marriage. The non-cancerous females were younger than the cancer patients (33.5 versus 43 years, respectively).
Conclusion: The study suggests the necessity of bringing fibroadenoma patients, in addition to breast cancer patients, into the screening programme and analysing the molecular profile because their BRCA1 expression is similar.
Antitumor activity of synthetic naphthoquinone derivatives (review)
Authors: Golovina E. L. , Serebryakova V. A. , Vaizova O. E.
Published: February 2025

Introduction. Cancer is the leading cause of death worldwide. Naphthoquinones are a group of natural organic compounds with a wide range of activity, including cardio-, hepato-, neuroprotective effects, as well as antimicrobial, anti-inflammatory and antitumor activity. 1,4-naphthoquinone is easily oxidized, reduced, and may be easily attached with nucleophiles. Well-developed methods of chemical modification of naphthoquinones make them attractive for the development of new types substances. It is known about the antitumor effect of natural naphthoquinone compounds – plumbagin, shikonin, lapachol. Antitumor antibiotics such as doxorubicin and daunorubicin have a 1,4-naphthoquinone fragment in their structure.

Text. This review is devoted to the analysis of information on the mechanisms of antitumor action of synthetic derivatives of 1,4-naphthoquinone. Possible targets of their antitumor action are discussed.

Conclusion. An analysis of the literature data showed that synthetic compounds based on the 1,4-naphthoquinone molecule have antitumor activity. The mechanism of antitumor action may be associated with the induction of apoptosis through the signaling pathway of mitogen-activated protein kinase (MAPK) and the pathway of the signal transducer and activator of transcription 3 (STAT3), inhibition of cell division cycle phosphatase (Cdc25), accumulation of reactive oxygen species (ROS), inhibition of angiogenesis. The data obtained by researchers from different countries confirm the prospects of searching for new compounds with antitumor activity among synthetic derivatives of 1,4-naphthoquinone for the development of new medicines based on them.
En märklig mans liv och arbete
Authors: Norrgård Stefan
Published: February 2025

I Finland är Johan Leche (1704–1764) mest känd för att ha gjort en serie meteorologiska och fenologiska observationer mellan 1748 och 1764. Att han anlände till Åbo utan tidens nyaste meteorologiska instrument, den så kallade svenska termometern, som utvecklats av Celsius i början av 1740-talet, påverkade utan tvekan Leches vetenskapliga liv och karriär. Tidigare forskning om Johan Leche kan grovt indelas i tre kategorier. Till den första kategorin hör klimathistoriska rekonstruktioner utgående från Leches meteorologiska och kryofenologiska observationer. Ett av uppsatsens mål är följaktligen att belysa tidigare obesvarade frågor gällande Leches meteorologiska observationer, såsom var de gjordes, om han de facto gjorde alla observationer ensam eller om han delade på bördan med någon kollega. Till den andra kategorin hör beskrivande biografiska verk om vetenskapsmannen Leche. I denna uppsats knyts klimatteorier samman med meteorologiska observationer och sett ur det här perspektivet kan Johan Leche inte studeras i ett vakuum. Av nämnda orsak intar även astronomen och Vetenskapsakademiens ständige sekreterare Pehr Wargentin (1717–1783), som också hjälpte Leche med sammanställningen av de meteorologiska observationerna, en central roll i uppsatsen. Till den tredje kategorin hör ett föredrag som hölls av Helsingfors universitets förste professor i meteorologi, Oscar Johansson (1878–1956). Johansson lyfte fram för tiden relevanta klimatologiska frågor och Leches reflektioner om periodicitet. Uppsatsens uppgift är således att belysa, för att citera Johansson, ”denna märklige mans lif och arbete”.
Pääkirjoitus
Authors: Välimäki Mari
Published: February 2025

Auraica julkaisee vuonna 2024 poikkeuksellisesti kaksi numeroa, joista ensimmäinen käsitteli Henrik Gabriel Porthania ja hänen perintöään. Käsillä olevassa vuoden 2024 toisessa numerossa ovat esillä muut Auraican painopistealueet: tiede- ja kulttuurihistoria.
Luettelo Turun akatemian professorien tieteellisten töiden käsikirjoituksista Turussa
Authors: Isotalo Juha
Published: February 2025

Tämä luettelo syntyi tarpeesta selvittää, mitä Turun akatemian professorien ja muun henkilökunnan tuottamia julkaisemattomia tieteellisiä käsikirjoituksia on löydettävissä turkulaisista arkistoista ja kirjastoista. Aikarajaus on akatemian Turun ajassa sen perustamisesta 1640 Turun paloon 1827.
Lectio praecursoria
Authors: Kunnas Liisa
Published: February 2025

FM Liisa Kunnaksen väitöskirja The Furthest Past. Historiography and the Conceptual History of Stone Age Archaeology in Finland, c. 1700–1940 tarkastettiin Helsingin yliopistossa 19.6.2024. Vastaväittäjänä toimi apulaisprofessori Gabriel Moshenska (University College London) ja kustoksena apulaisprofessori Kristin Ilves. Väitöskirja on julkaistu Helsingin yliopiston sarjassa Dissertationes Universitatis Helsingiensis. Julkaisemme Kunnaksen lectio praecursorian.
Family pressure for heterosexual marriage: The experience of Chinese queer people
Authors:   , Zhu Junfeng
Published: February 2025

In China, millions of queer people engage in heterosexual marriage, as evidenced by the increasing popularity of formality marriages (i.e., a marriage between a queer man and a queer woman) among queer people and by the millions of queer individuals who engage in a lesbian’s husband marriage or gay’s wife marriage (i.e., the marriage between a queer person and a heterosexual person). Yet heterosexual marriage has caused considerable difficulties for Chinese queer individuals, affecting both their emotional and general well-being. A primary reason cited by Chinese queer individuals for entering into heterosexual marriages is family pressure, especially the pressure from parents. Crucially, while prior research suggested some potential antecedents and consequences of family pressure, these findings are scattered across different studies and mainly based on qualitative insights. There is significantly less research that systematically investigates family pressure and statistically tests the relationships between family pressure and its antecedents and consequences.
To develop a comprehensive understanding of family pressure, this dissertation aims to systematically examine the family pressure experienced by Chinese queer individuals to engage in heterosexual marriage, as well as statistically test the relationships between family pressure and its antecedents and consequences. To fill the gaps, I conducted a systematic review to understand the existing knowledge of family pressure (Chapter 2), two empirical quantitative studies to statistically test the relationships between family pressure and its antecedents and consequences (Chapters 3 and 5), and one empirical qualitative study to deepen our knowledge related to the antecedents in Chinese society (Chapter 4).
This dissertation found that family pressure to engage in heterosexual marriage was shaped by the joint influences of heteronormativity in marriage and authoritarian filial piety. Experiencing family pressure exacerbated mental distress and reduced general life satisfaction of Chinese queer individuals. This dissertation serves as an initial exploration into the experiences of Chinese queer individuals facing family pressure to engage in heterosexual marriages. To protect wellbeing of queer people facing family pressure to engage in heterosexual marriage, this dissertation asks for persistent questioning of how social norms influence queer people and their marital practices, as well as the presentation of individual experiences under the overwhelming social construction.
Ozanimod▼ in Ulcerative Colitis: Key New Data
Authors: Humphry Nicola
Published: February 2025

Ozanimod is an oral medication indicated for the treatment of moderately-to-severely active ulcerative colitis (UC) in adults. This review article summarises the latest data on the long-term efficacy and safety of ozanimod in patients with UC, presented at the United European Gastroenterology Week (UEGW) held in Vienna, Austria, between 12th–15th October 2024 and the American College of Gastroenterology’s (ACG) Annual Scientific Meeting held in Philadelphia, Pennsylvania, USA, between 25th–30th October 2024. Updated analyses of the True North study (which met its primary endpoint) and associated ongoing open label extension (OLE) study demonstrated that ozanimod efficacy and generally well tolerated safety profile were durable over 5 years of continuous treatment. In a real-world setting, ozanimod induced a clinical response in both advanced therapy (AT)-naïve and AT-experienced patients, though remission rates were slightly lower in patients with prior exposure to ≥3 ATs. In addition, an evaluation of long-term exposure to ozanimod over 16,000 patient years (PY), in a pooled analysis of clinical studies in moderately-to-severely active UC or relapsing multiple sclerosis (RMS), showed that incidence rates for the most frequent treatment-emergent adverse events (TEAE) and TEAEs of interest were low and were similar across both patient populations. Together, these new data confirm that the ongoing efficacy and safety profile of ozanimod is consistent with previous analyses.
Human Metapneumovirus (HMPV) Outbreaks in Focus: A call for Preparedness and Action
Authors: Mamun Abdullah Al , Hapsari Rafif Naufi Waskitha
Published: February 2025

Not mandatory
Case Report: Term Birth with Unknown Intrauterine Device (IUD) in Situ
Authors: Mustikasari Melisa Indah , Pamungkas Aditya Fendi Uji , Azkia Razita Aulia , Putri Made Chindy Dwiyanti Marheni , Wiguna I Made Ananta
Published: February 2025

Intrauterine contraceptive devices (IUDs) are highly efficient at preventing unintended pregnancies, without minimal failure rates, rare complications such as retention or displacement during pregnancy may lead to significant clinical challenge. This case discusses the diagnostic and management challenges of presumed IUD retention in the background of poor antenatal care. Multigravida woman, GIII/PII/A0, 24 years old with two previous caesarean deliveries, admitted in active labor at term. She received no antenatal care for her pregnancy because she could not afford it, and she thought that, because she had an IUD placed after her last cesarean section, she was infertile. On examination, uterine fundal height was 34 cm, amniotic membranes were intact, and the cervix was fully dilated as labor progressed. Spontaneous vaginal delivery was achieved and a 4050-gram (9 lb) neonate was delivered with Apgar scores of 4 at one minute and 5 at five minutes. In the postpartum period, she experienced complications including retained placenta requiring manual extraction and an estimated blood loss of 250 mL. After complete exploration and subsequent imaging, the IUD was not visualized, suggesting either early expulsion, unnoticed displacement or misplacement occurred at insertion. The patient’s postpartum course was unremarkable with appropriate uterotonic therapy and close observation. This case highlights the need for full antenatal care to prevent and manage complications associated with IUDs including displacement or retention that may result in adverse maternal and fetal outcomes. Timely diagnosis and early interventions coupled with appropriate imaging and clinical follow-up services are essential to optimize outcomes and minimize associated risks.
Descriptive Epidemiology of Tuberculosis-Diabetes Mellitus Co-Infection in Respira Paru Hospital: A Study of Incidence from 2021 to 2023
Authors: Rizkika Bunga Bilbina , Sofiana Liena , Oktaviana Ardyawati Wira
Published: February 2025

Background: Tuberculosis (TB) and Diabetes Mellitus (DM) are global problems, especially in countries with high TB endemicity. The relationship between TB and DM is more dominant in developing countries where TB is endemic, and the prevalence of DM is increasing. The risk of death during TB treatment and the risk of relapse after treatment is higher in TB patients with comorbid DM. More than 10% of TB patients are also known to have DM. This study aims to determine the epidemiological picture of TB-DM incidence based on time, place and person. Methods: This study uses a descriptive quantitative design with a case study approach; the analysis used is univariate analysis using proportions. The population of TB-DM patients in 2021-2023 was recorded in medical records, with a purposive sampling technique obtained from 110 people. Results: The epidemiological picture of TB-DM cases based on the characteristics of the person is age ≥ 45 years (80.9%), male gender (71.8%), type of pulmonary TB (98.2%), bacteriologically confirmed TB diagnosis (73.6%), the final result of TB treatment is cured (52.7%), type of DM therapy is insulin injection (76.4%) and high random blood sugar levels > 200 mg/dL (64.5%). Conclusions: The epidemiological picture of TB-DM cases for three years (2021-2023) has an upward trend and the highest cases in 2022; the majority of TB-DM cases are male, aged > 45 years, with the most cases coming from Bantul Regency.
Comparison Between General and Spinal Anesthesia in the Effect on Hemodynamic Stability in Patients Undergoing Hernia Repair in Hospitals in Karbala, Iraq
Authors: Kadhim Adnan Abdul Adheem , Salem Al-Khikani Haider Ahmed Jalab , Hamza Qasim Muhammad , Habib Yass Khudair , Hussein Muhammad Mohsen , Muhammad Hassan Taqi
Published: February 2025

Background: Among the various methods, drugs, strategies, and guidelines for optimal anesthesia selection, the anesthesia and critical care staff primarily aim to choose the anesthetic with the least risk to the patient. Spinal anesthesia is one of the most effective and commonly used forms of anesthetic for hernia repair procedures. This study aims to provide an updated and accurate analysis of patients undergoing hernia repair at Karbala's Al-Hassan Hospital and Al-Hussein Medical City. Methods: We divided 100 patients who underwent herniotomy into two groups based on the type of anesthesia received: 50 patients received spinal anesthesia (SA), and 50 received general anesthesia (GA). The analysis included patient age, weight, changes in blood pressure, and pulse rate. To ensure comprehensive monitoring, patients aged 20 to 90 years were followed before, during, and after the procedure. Results: The results indicate greater hemodynamic stability in patients who received SA, with approximately 56% of patients demonstrating stable parameters compared to 40% in the GA group. However, higher blood pressure was observed more frequently in the GA group (32%) compared to the SA group (24%). Similarly, lower blood pressure was more common in GA (28%) than in SA (20%). Heart rate analysis revealed that SA resulted in greater stability, with 56% of patients maintaining a stable heart rate, compared to 32% in the GA group. Conversely, an increased heart rate was observed in 34% of patients in the SA group compared to 60% in the GA group. A decreased heart rate was reported in 10% of SA patients and 8% of GA patients, further supporting the conclusion that SA provides more stable outcomes. Conclusions: Spinal anesthesia was found to be superior to general anesthesia in maintaining heart rate and blood pressure stability at normal or minimally fluctuating levels.
Molecular epidemiology and genetic dynamics of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China
Authors: Li Xiangchen , Chen Sisi , Lu Yewei , Shen Weifeng , Wang Weixin , Gao Junli , Gao Junshun , Shao Pingyang , Zhou Zhuxian
Published: February 2025

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CRhvKP) poses a significant global health threat due to its enhanced virulence and resistance. This study analyzed 5,036 publicly available K. pneumoniae genomes from China (2005–2023), identifying 1,538 CRhvKP genomes, accounting for 44.6% of carbapenem-resistant isolates and 69.5% of hypervirulent isolates. Predominant carbapenemases included blaKPC (92.1%), with an increasing prevalence of blaNDM and blaOXA-48-like genes. Most isolates (93.6%) carried both aerobactin and yersiniabactin genes. The genetic background showed high diversity, characterized by 36 sequence types (STs) and 22 capsule types, with high-risk endemic STs such as ST11, ST15, and ST23 being predominant. ST23 demonstrated enhanced virulence, whereas ST11 carried more resistance genes but showed minimal presence of iroBCDN genes. A core genome MLST analysis revealed that 89.0% of CRhvKP isolates clustered into 131 clonal groups, indicating widespread dissemination, particularly in eastern China. CR and hv plasmids, primarily IncF, IncH, and IncR types, showed distinct community structures, with CR plasmids demonstrating higher mobility and diversity. Crucially, we identified 40 CR-hv convergent plasmids across five STs, likely resulting from plasmid fusions, which have become increasingly prevalent in eastern China over the last decade. Furthermore, chromosomal integration of hv genes and blaKPC-2 was detected, underscoring the stable inheritance of these traits. Class 1 Integrons were present in 84.5% of CRhvKP strains, most notably in ST11 and least in ST23. These integrons harbored genes that confer resistance to various antibiotics, including blaIMP and blaVIM, with their content varying across different STs. This study highlights the genetic complexity, rapid dissemination, and increasing prevalence of CRhvKP in China, emphasizing the urgent need for enhanced genomic surveillance and targeted interventions to mitigate the threat posed by these multidrug-resistant and hypervirulent strains.
Inducing hypertension in Myh11R247C/R247C mice triggers aortic dissections with increased focal adhesion kinase signaling
Authors: Kwartler Callie S. , Wang Shanzhi , Zhou Zhen , Guan Pujun , Yu Yang , Duan Xue-Yan , Zhang Theodore , Chen Jiyuan , Davis Elaine C. , Milewicz Dianna M.
Published: February 2025

Objective

We sought to determine if hypertension in combination with a “variant of uncertain significance” that disrupts protein function, MYH11 p.Arg247Cys, would induce aortic dissections in a mouse model.

Approach and results

Administration of L-NAME via drinking water and a high salt diet increased blood pressure in WT and Myh11R247C/R247C mice and triggered type A dissections with cardiac tamponade in 20% of the Myh11R247C/R247C mice. Myh11R247C/R247C aortas have aberrant smooth muscle contractile unit-elastin connections by transmission electron microscopy, along with increased focal adhesion signaling at baseline, which further increases with hypertension.

Conclusion

Gene-environment interactions trigger aortic dissections in Myh11R247C/R247C mice.
Numerical simulation research on the micro failure mechanism of sandstone under freeze-thaw cycles
Authors: Tao Li , Peng Wu , Shanchao Hu , Boyuan Wu , Zhanqing Chen
Published: February 2025

The process of micro crack formation in sandstone subjected to freeze-thaw cycles is pivotal for strip mine in cold regions. A discrete element numerical model considering the variation of frost heave force and water saturation during the freeze-thaw cycles is established by PFC3D in this paper. The results indicate that: (1) During freeze-thaw cycles, the development of cracks can be divided into three stages: stable, growth and explosive stage. The crack quantity in the stable and growth stage increases exponentially, while the quantity of cracks in the explosive stage increases linearly quickly. (2) Repeated freeze-thaws cause progressive damage to rocks from surface to interior. As the times of freeze-thaw increase, cracks gradually develop, and their distribution becomes more uniform on different angles. (3) Sandstone that have undergone freeze-thaw cycles is more prone to tensile failure, and the distribution of cracks becomes even more complex. These research findings provide a more accurate understanding of micro-fracture mechanisms in rocks in the freeze-thaw condition.
Experimental investigation of grid storage modes effect on aging of LiFePO4 battery modules
Authors: Xu Jianhong , Li Haozhan , Hua Sicong , Wang Hao
Published: February 2025

Introduction

To investigate the degradation behavior of energy storage batteries during grid services, we conducted a cyclic aging test on LiFePO4 battery modules.

Methods

Incorporating variables such as grid duty, temperature and depth of discharge, we analyzed the capacity degradation and operational patterns in different grid- storage interaction modes by examining aspects of capacity retention, discharge quantity, incremental capacity, and differential voltage.

Results

Our findings indicate that battery degradation is higher during peak shaving compared to frequency regulation. Heat and deep charging and discharging modes accelerates battery aging.

Discussion

The primary source of performance degradation in LiFePO4 batteries is Li loss.
Integrating pollinators’ movements into pollination models
Authors: Mailly Juliane , Riotte-Lambert Louise , Lihoreau Mathieu
Published: February 2025

Accurate prediction of pollination processes is a key challenge for sustainable food production and the conservation of natural ecosystems. For many plants, pollen dispersal is mediated by the foraging movements of nectarivore animals. While most current models of pollination ecology assume random pollen movements, studies in animal behaviour show how pollinating insects, birds and bats rely on sensory cues, learning and memory to visit flowers, thereby producing complex movement patterns. Building upon a brief review of pollination and movement models, we argue that we need to better consider pollinators’ cognition to improve predictions of animal-mediated pollination across all spatial scales, from individual flowers, to plants, habitat patches and landscapes. We propose a practical roadmap for the integration of behavioural models into pollination models and discuss how this synthesis can refine predictions regarding plant mating patterns and fitness. Such crosstalk between animal behaviour and plant ecology research will provide powerful mechanistic tools to predict and act on pollination services in the context of a looming crisis.
A bibliometric and visualization analysis of the role of traditional Chinese medicine in cancer immunotherapy
Authors: Lian Yixiao , Sun Jie , Yang Lin , Yu Weidong
Published: February 2025

Objective

Traditional Chinese medicine (TCM) is used as a complementary treatment for patients with cancer, especially in immunotherapy. Although extensive clinical and basic research has been conducted on TCM in cancer immunotherapy, a comprehensive bibliometric analysis of this field has not yet been performed. This study aimed to investigate the progress and status of TCM, and the research focused on cancer immunotherapy.

Methods

We collected 1,657 articles on TCM in cancer immunotherapy from 1994 to 2024 from the Web of Science Core Collection database. VOSviewer, CiteSpace, and the Bibliometrix R package were used to analyze countries, institutions, journals, authors, references, and keywords to predict future trends in cancer immunotherapy with TCM.

Results

The publication rate of TCM in cancer immunotherapy research steadily increased from 1994 to 2018, with a swift growth from 2018 to 2023. China and TCM universities have achieved the most research advancements in this field. The most studied types of cancer are liver, lung, and colorectal cancers. However, few studies exist on upper respiratory tract tumors, cervical cancer, and melanoma, which deserve more attention. The study trend has gradually shifted from in vivo and in vitro models to clinical efficacy. Simultaneously, the focus of research transitioned from compound TCM preparations or classes of ingredients to specific pharmacodynamic ingredients, and the corresponding targets transitioned from cytokines to immune checkpoints. In general, molecular docking combined with multi-omics analysis is a popular and trending research method in TCM for cancer immunotherapy, helping researchers understand the mechanisms of TCM in cancer immunotherapy more comprehensively and accurately. By analyzing the literature, it is evident that TCM-based immunotherapy should contribute to effective maintenance or adjuvant therapy throughout the entire course of cancer rather than only in the late stages.

Conclusion

This study comprehensively summarized and identified research frontiers providing a reference for promoting the development of TCM immunotherapy preparations and guiding clinical practice. Consequently, more patients with cancer can benefit from immunotherapy.
Exosome tropism and various pathways in lung cancer metastasis
Authors: Chen Hui , Liu Lin , Xing Gang , Zhang Dan , A. Niumuqie , Huang Jianlin , Li Yaling , Zhao Ge , Liu Minghua
Published: February 2025

Lung cancer, characterized by its high morbidity and mortality rates, has the capability to metastasize to various organs, thereby amplifying its detrimental impact and fatality. The metastasis of lung cancer is a complex biological phenomenon involving numerous physiological transformations. Exosomes, small membranous vesicles enriched with biologically active components, are pivotal in mediating intercellular communication and regulating physiological functions due to their specificity and stability. Extensive research has elucidated the production and functions of exosomes in cancer contexts. Multitude of evidence demonstrates a strong association between lung cancer metastasis and exosomes. Additionally, the concept of the pre-metastatic niche is crucial in the metastatic process facilitated by exosomes. This review emphasizes the role of exosomes in mediating lung cancer metastasis and their impact on the disease’s development and the progression to other tissues. Furthermore, it explores the potential of exosomes as biomarkers for lung cancer metastasis, offering significant insights for future clinical advancements.
A nomogram for predicting cancer-specific survival in patients with locally advanced unresectable esophageal cancer: development and validation study
Authors: Xie Liangyun , Zhang Yafei , Niu Xiedong , Jiang Xiaomei , Kang Yuan , Diao Xinyue , Fang Jinhai , Yu Yilin , Yao Jun
Published: February 2025

Background

Immunotherapy research for esophageal cancer is progressing rapidly, particularly for locally advanced unresectable cases. Despite these advances, the prognosis remains poor, and traditional staging systems like AJCC inadequately predict outcomes. This study aims to develop and validate a nomogram to predict cancer-specific survival (CSS) in these patients.

Methods

Clinicopathological and survival data for patients diagnosed between 2010 and 2021 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were divided into a training cohort (70%) and a validation cohort (30%). Prognostic factors were identified using the Least Absolute Shrinkage and Selection Operator (LASSO) regression. A nomogram was constructed based on the training cohort and evaluated using the concordance index (C-index), net reclassification improvement (NRI), integrated discrimination improvement (IDI), calibration plots, and area under the receiver operating characteristic curve (AUC). Kaplan-Meier survival curves were used to validate the prognostic factors.

Results

The study included 4,258 patients, and LASSO-Cox regression identified 10 prognostic factors: age, marital status, tumor location, tumor size, pathological grade, T stage, American Joint Committee on Cancer (AJCC) stage, SEER stage, chemotherapy, and radiotherapy. The nomogram achieved a C-index of 0.660 (training set) and 0.653 (validation set), and 1-, 3-, and 5-year AUC values exceeded 0.65. Calibration curves showed a good fit, and decision curve analysis (DCA), IDI, and NRI indicated that the nomogram outperformed traditional AJCC staging in predicting prognosis.

Conclusions

We developed and validated an effective nomogram model for predicting CSS in patients with locally advanced unresectable esophageal cancer. This model demonstrated significantly superior predictive performance compared to the traditional AJCC staging system. Future research should focus on integrating emerging biomarkers, such as PD-L1 expression and tumor mutational burden (TMB), into prognostic models to enhance their predictive accuracy and adapt to the evolving landscape of immunotherapy in esophageal cancer management.
Research trends of inflammation in autism spectrum disorders: a bibliometric analysis
Authors: Chen Yajing , Du Xiaohuan , Zhang Xianming , Li Fang , Yuan Shuwei , Wang Wenjing , Zhu Zengyan , Wang Mei , Gu Chao
Published: February 2025

Background

Inflammation has been recognized as a significant factor in the pathophysiology of autism spectrum disorders (ASD), which have garnered increasing scholarly attention over the past few decades. This study aims to explore research trends related to inflammation and ASD through bibliometric analysis.

Method

A comprehensive literature search was conducted in the Web of Science Core Collection (WoSCC) on August 28, 2024. This study was restricted to literature published in English. The bibliometric analysis utilized VOSviewer, CiteSpace, and the R package “bibliometrix” to visualize collaborations, keyword co-occurrences, and emerging research trends.

Results

A total of 1,752 articles addressing inflammation and ASD were published, demonstrating a consistent upward trend in research output. The United States emerged as the country with the highest volume of publications. Saleh A. Bakheet was identified as the most prolific authors, significantly contributing to the literature with 54 publications. The University of California System was recognized as the most productive institution in this area of study. The journal of Brain Behavior and Immunity was noted as a prominent venue for publication in this field, exhibiting high citation metrics that reflect its considerable influence. The keyword “children” was the most frequently occurring term, with other significant terms including “oxidative stress” and “brain.” The keyword burst analysis revealed notable periods of increased research focus on topics such as “inflammatory bowel disease,” “cytokine production,” “neurodevelopmental disorders,” and “microbiota.”

Conclusion

This bibliometric analysis highlights the growing scholarly attention devoted to the relationship between inflammation and ASD. Significant contributions and emerging trends emphasize the pivotal role of neuroinflammation in ASD, indicating a necessity for further exploration in this domain.