bluuebunny/crossref_metadata_2025 huggingface dataset:
Health Experts’ Perspectives on Barriers, Facilitators, and Needs for Improvement of Hospital Care in the Dying Phase
Authors: Kaur Sukhvir , Boström Kathleen , Ullrich Anneke , Oubaid Nikolas , Oechsle Karin , Schulz Holger , Voltz Raymond , Kremeike Kerstin
Published: September 2024

Introduction. Globally, hospitals are an important place in end‐of‐life care and most frequent place of death in Germany (47%), but at the same time, the least preferred one—both for patients and their informal caregivers. As hospital care in the dying phase on non‐palliative care wards has rarely been studied systematically, we assessed the current state of care in the dying phase in hospitals as a first step. Methods. In an online survey, N = 165 national health experts were invited to answer eight open questions on care aspects, facilitators, barriers, and needs for improvement as well as COVID‐19 pandemic specifics regarding hospital care in the dying phase. Sociodemographic data were analysed descriptively, and responses were analysed using qualitative thematic analysis. Results. Of n = 65 experts, 52% work as nursing staff and 30% as physicians. We identified facilitators, barriers, and needs for improvement regarding 11 topics on the following three levels: institutional level (general institutional conditions, hospital culture, and integration of specialist palliative care), team level (attitude towards and dealing with death and dying, competencies, communication, and teamwork) and care level (dying phase, symptom control, patient centredness, and involvement of informal caregivers). Conclusion. Improving care in the dying phase has to overcome barriers on various levels. We assume that rather “small” measures will find their way into clinical routine and contribute to the improvement of hospital care in the dying phase.
Measuring Cardiovascular Disease Risk Perception: Translation and Validation of the Indonesian ABCD Risk Questionnaire
Authors: Lumbantoruan Septa Meriana , Uligraff Deby Kristiani , Tallutondok Eva Berthy
Published: September 2024

Background. Cardiovascular diseases (CVDs) are still increasing worldwide contributing to increasing death worldwide. To test CVDs’ awareness, the Attitude and Belief about Cardiovascular Disease (ABCD) questionnaire was developed. However, this questionnaire is not available in Indonesia language. Methods. The original questionnaire was translated in both directions forward and backward. The process is then continued with a content validity index created by three experts. The exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) then determine the factors that support the translated questionnaire. The splitting sample method was applied in both factor analyses. Internal consistency testing of 18 items was performed on 236 samples. Result. The validity of the entire questionnaire subscale was satisfactory. Three retained factors were supported by the EFA and CFA, namely, risk perception, perceived benefit, and healthy eating intention. The internal consistency was acceptable based on Cronbach alpha and ordinal alpha. The Indonesian version of ABCD questionnaire was statistically valid and reliable to be used. Conclusion. The Indonesian version of the ABCD questionnaire is a valid questionnaire to access the attitude and belief of CVDs in Indonesia.
Supplementary Table S1 from Long-Term Risks of Cardiovascular Death among Older Patients with Major Hematological Malignancies: A Population-Based Cohort Study from SEER Database
Authors: Zhang Hanqing , He Minghao , Zhang Peng , Gao Yang , Ouyang Ling , He Xianjun , Han Na , Zhang Jinfeng , Guan Mengshan , Feng Yueqi , Li Yonghua
Published: September 2024

Supplementary Table S1. The histology/morphology codes fort 7 types of hematological malignancies.
Supplementary Figure S7 from A Phase II Study of Potentiation of Pembrolizumab with Binimetinib and Bevacizumab in Refractory Microsatellite-Stable Colorectal Cancer
Authors: Lentz Robert W. , Friedrich Tyler J. , Blatchford Patrick J. , Jordan Kimberly R. , Pitts Todd M. , Robinson Hannah R. , Davis S. Lindsey , Kim Sunnie S. , Leal Alexis D. , Lee Mathew R. , Waring Meredith R.N. , Martin Anne C. , Dominguez Adrian T.A. , Bagby Stacey M. , Hartman Sarah J. , Eckhardt S. Gail , Messersmith Wells A. , Lieu Christopher H.
Published: September 2024

Supplementary Figure S7. Correlation of baseline immune cell populations with response to treatment in Cohorts A and B.
Supplemental Table 3 from A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer
Authors: Choudhury Noura J. , Lai W. Victoria , Makhnin Alex , Heller Glenn , Eng Juliana , Li Bob , Preeshagul Isabel , Santini Fernando C. , Offin Michael , Ng Kenneth , Paik Paul , Larsen Christina , Ginsberg Michelle S. , Lau Yvonne , Zhang Xinyuan , Baine Marina K. , Rekhtman Natasha , Rudin Charles M.
Published: September 2024

Immunohistochemistry results
Supplementary Figure S1 from Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
Authors: Lee Horace H.Y. , Chow Kin Long , Wong Ho Shing , Chong Tsz Yan , Wong Alice S.T. , Cheng Grace H.W. , Ko Jasmine M.K. , Siu Hoi Cheong , Yeung Maximus C.F. , Huen Michael S.Y. , Tse Ka Yu , Bray Mark R. , Mak Tak Wah , Leung Suet Yi , Ip Philip P.C.
Published: September 2024

Supplementary Figure S1. Sanger sequencing of SK-UT-1 and SKN BRAC2-KO.
Figure S1 from Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol
Authors: Geurts Birgit S. , Zeverijn Laurien J. , Leek Lindsay V.M. , van Berge Henegouwen Jade M. , Hoes Louisa R. , van der Wijngaart Hanneke , van der Noort Vincent , van de Haar Joris , van Ommen-Nijhof Annemiek , Kok Marleen , Roepman Paul , Jansen Anne M.L. , de Leng Wendy W.J. , de Jonge Maja J.A. , Hoeben Ann , van Herpen Carla M.L. , Westgeest Hans M. , Wessels Lodewyk F.A. , Verheul Henk M.W. , Gelderblom Hans , Voest Emile E.
Published: September 2024

Figure S1. CONSORT flow diagram.
Supplemental Table 3 from Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer
Authors: Lenis Andrew T. , Ravichandran Vignesh , Brown Samantha , Alam Syed M. , Katims Andrew , Truong Hong , Reisz Peter A. , Vasselman Samantha , Nweji Barbara , Autio Karen A. , Morris Michael J. , Slovin Susan F. , Rathkopf Dana , Danila Daniel , Woo Sungmin , Vargas Hebert A. , Laudone Vincent P. , Ehdaie Behfar , Reuter Victor , Arcila Maria , Berger Michael F. , Viale Agnes , Scher Howard I. , Schultz Nikolaus , Gopalan Anuradha , Donoghue Mark T.A. , Ostrovnaya Irina , Stopsack Konrad H. , Solit David B. , Abida Wassim
Published: September 2024

Supplemental Table 3
Figure 2 from Safety, Efficacy, and Biological Data of T-Cell–Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial
Authors: Pakola Santeri A. , Peltola Katriina J. , Clubb James H.A. , Jirovec Elise , Haybout Lyna , Kudling Tatiana V. , Alanko Tuomo , Korpisaari Riitta , Juteau Susanna , Jaakkola Marjut , Sormunen Jorma , Kemppainen Jukka , Hemmes Annabrita , Pellinen Teijo , van der Heijden Mirte , Quixabeira Dafne C.A. , Kistler Claudia , Sorsa Suvi , Havunen Riikka , Santos Joao M. , Cervera-Carrascon Victor , Hemminki Akseli
Published: September 2024

A, Response evaluation in all injected lesions, evaluated by CT. B, Response evaluation in all injected lesions, evaluated by PET. C, Response evaluation in allimaged non-injected lesions, evaluated by CT. D, Response evaluation in all imaged non-injected lesions, evaluated by PET. Best response shown for A–D if patient continued to extension. E, Intravenous dose given versus sum SUVmax change of measured lesions on day 78. F, Intratumoral dose given versus sum SUVmax change of measured lesions on day 78. G, Overall survival in the trial. H, Progressionfree survival in the trial. I, Time to progression in the trial. J, Swimmer plot of the patients enrolled in the trial. For E and F, linear fit shown with 95% confidence intervals shown with R2 for goodness of fit and P value for slope deviation from zero. For G–I, disease control defined with PET-based criteria and comparison of disease control and no disease control evaluated with Mantel–Cox Log-rank test. ***, P < 0.001; ****, P < 0.0001.
Supplementary Table S10 from Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma
Authors: Pourmaleki Maryam , Jones Caitlin J. , Mellinghoff Sabrina D. , Greenstein Brian D. , Kumar Priyadarshini , Foronda Miguel , Navarrete Daniel A. , Campos Carl , Roshal Mikhail , Schultz Nikolaus , Shah Sohrab P. , Schietinger Andrea , Socci Nicholas D. , Hollmann Travis J. , Dogan Ahmet , Mellinghoff Ingo K.
Published: September 2024

Supplementary Table S10. Comparison of EBV-negative neighborhoods.
Supplemental Table 4 from Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets
Authors: Chen Monica F. , Yang Soo-Ryum , Tao Jessica J. , Desilets Antoine , Diamond Eli L. , Wilhelm Clare , Rosen Ezra , Gong Yixiao , Mullaney Kerry , Torrisi Jean , Young Robert J. , Somwar Romel , Yu Helena A. , Kris Mark G. , Riely Gregory J. , Arcila Maria E. , Ladanyi Marc , Donoghue Mark T.A. , Rosen Neal , Yaeger Rona , Drilon Alexander , Murciano-Goroff Yonina R. , Offin Michael
Published: September 2024

Supplemental Table 4. Treatments prior to identification of acquired BRAF fusions.
Supplementary Figure S8 from Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma
Authors: Pourmaleki Maryam , Jones Caitlin J. , Mellinghoff Sabrina D. , Greenstein Brian D. , Kumar Priyadarshini , Foronda Miguel , Navarrete Daniel A. , Campos Carl , Roshal Mikhail , Schultz Nikolaus , Shah Sohrab P. , Schietinger Andrea , Socci Nicholas D. , Hollmann Travis J. , Dogan Ahmet , Mellinghoff Ingo K.
Published: September 2024

Supplementary Figure S8. B2M/MHCI/MHCII/PDL1-related HRS cell neighborhoods.
Supplementary Figure S5 from Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma
Authors: Pourmaleki Maryam , Jones Caitlin J. , Mellinghoff Sabrina D. , Greenstein Brian D. , Kumar Priyadarshini , Foronda Miguel , Navarrete Daniel A. , Campos Carl , Roshal Mikhail , Schultz Nikolaus , Shah Sohrab P. , Schietinger Andrea , Socci Nicholas D. , Hollmann Travis J. , Dogan Ahmet , Mellinghoff Ingo K.
Published: September 2024

Supplementary Figure S5. Heterogeneity in HRS cell states and their spatial distribution.
Supplementary Figure S8 from Targeting AKR1B10 by Drug Repurposing with Epalrestat Overcomes Chemoresistance in Non–Small Cell Lung Cancer Patient-Derived Tumor Organoids
Authors: Suvilesh Kanve N. , Manjunath Yariswamy , Nussbaum Yulia I. , Gadelkarim Mohamed , Raju Murugesan , Srivastava Akhil , Li Guangfu , Warren Wesley C. , Shyu Chi-Ren , Gao Feng , Ciorba Matthew A. , Mitchem Jonathan B. , Rachagani Satyanarayana , Kaifi Jussuf T.
Published: September 2024

Supplementary Figure S8. Quantification of AKR1B10 expression in resistant and sensitive PDTOs and matched patient tumor tissues.
Figure S2 from Endoplasmic Reticulum Stress Potentiates the Immunosuppressive Microenvironment in Hepatocellular Carcinoma by Promoting the Release of SNHG6-Enriched Small Extracellular Vesicles
Authors: Liu Chengdong , Zhou Xiaohan , Zeng Hanyi , Yu Jiaping , Li Wenwen , Zhang Wanli , Liao Yanxia , Wang Haijian , Liu Li
Published: September 2024

Supplementary Fig. S2. Bioinformatics analysis of ATF4 and ER stress score
Table S7 from Nivolumab Reaches Brain Lesions in Patients with Recurrent Glioblastoma and Induces T-cell Activity and Upregulation of Checkpoint Pathways
Authors: Skadborg Signe K. , Maarup Simone , Draghi Arianna , Borch Annie , Hendriksen Sille , Mundt Filip , Pedersen Vilde , Mann Matthias , Christensen Ib J. , Skjøth-Ramussen Jane , Yde Christina W. , Kristensen Bjarne W. , Poulsen Hans S. , Hasselbalch Benedikte , Svane Inge M. , Lassen Ulrik , Hadrup Sine R.
Published: September 2024

Multivariate analysis of CA209-9UP patients (N=40).
Table S6 from Nivolumab Reaches Brain Lesions in Patients with Recurrent Glioblastoma and Induces T-cell Activity and Upregulation of Checkpoint Pathways
Authors: Skadborg Signe K. , Maarup Simone , Draghi Arianna , Borch Annie , Hendriksen Sille , Mundt Filip , Pedersen Vilde , Mann Matthias , Christensen Ib J. , Skjøth-Ramussen Jane , Yde Christina W. , Kristensen Bjarne W. , Poulsen Hans S. , Hasselbalch Benedikte , Svane Inge M. , Lassen Ulrik , Hadrup Sine R.
Published: September 2024

Multivariate analysis of CA209-9UP patients (N=40).
Figure S6 from Nivolumab Reaches Brain Lesions in Patients with Recurrent Glioblastoma and Induces T-cell Activity and Upregulation of Checkpoint Pathways
Authors: Skadborg Signe K. , Maarup Simone , Draghi Arianna , Borch Annie , Hendriksen Sille , Mundt Filip , Pedersen Vilde , Mann Matthias , Christensen Ib J. , Skjøth-Ramussen Jane , Yde Christina W. , Kristensen Bjarne W. , Poulsen Hans S. , Hasselbalch Benedikte , Svane Inge M. , Lassen Ulrik , Hadrup Sine R.
Published: September 2024

CNS homing - and activation markers and inhibitory checkpoint molecules on PBMC derived T-cells.
Figure S18 from Nivolumab Reaches Brain Lesions in Patients with Recurrent Glioblastoma and Induces T-cell Activity and Upregulation of Checkpoint Pathways
Authors: Skadborg Signe K. , Maarup Simone , Draghi Arianna , Borch Annie , Hendriksen Sille , Mundt Filip , Pedersen Vilde , Mann Matthias , Christensen Ib J. , Skjøth-Ramussen Jane , Yde Christina W. , Kristensen Bjarne W. , Poulsen Hans S. , Hasselbalch Benedikte , Svane Inge M. , Lassen Ulrik , Hadrup Sine R.
Published: September 2024

Immunogenic vs. non-immunogenic neoepitopes.
Figure S11 from Nivolumab Reaches Brain Lesions in Patients with Recurrent Glioblastoma and Induces T-cell Activity and Upregulation of Checkpoint Pathways
Authors: Skadborg Signe K. , Maarup Simone , Draghi Arianna , Borch Annie , Hendriksen Sille , Mundt Filip , Pedersen Vilde , Mann Matthias , Christensen Ib J. , Skjøth-Ramussen Jane , Yde Christina W. , Kristensen Bjarne W. , Poulsen Hans S. , Hasselbalch Benedikte , Svane Inge M. , Lassen Ulrik , Hadrup Sine R.
Published: September 2024

T cell analyses without tumor samples from petiens treated with steriod.
Supplementary Tables from Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors
Authors: Chang Ju-Fang , Wellhausen Nils , Engel Nils W. , Landmann Jack H. , Hopkins Caitlin R. , Salas-McKee January , Bear Adham S. , Selli Mehmet E. , Agarwal Sangya , Jadlowsky Julie K. , Linette Gerald P. , Gill Saar , June Carl H. , Fraietta Joseph A. , Singh Nathan
Published: September 2024

Supplementary Tables S1 and S2
Supplementary Figure S6 from Intracellular Osteopontin Promotes the Release of TNFα by Mast Cells to Restrain Neuroendocrine Prostate Cancer
Authors: Sulsenti Roberta , Scialpi Giuseppina B. , Frossi Barbara , Botti Laura , Ferri Renata , Tripodi Irene , Piva Annamaria , Sangaletti Sabina , Pernici Davide , Cancila Valeria , Romeo Francesco , Chiodoni Claudia , Lecis Daniele , Bianchi Francesca , Fischetti Irene , Enriquez Claudia , Crivelli Filippo , Bregni Marco , Renne Giuseppe , Pece Salvatore , Tripodo Claudio , Pucillo Carlo E. , Colombo Mario P. , Jachetti Elena
Published: September 2024

Supplementary Figure S6. Quantification of western blot. A. Quantification of western blot reported in Fig. 3G. Western blots were validated twice. All histograms depict mean ± SD of biological replicates (represented by dots). One-way ANOVA followed by Tukey’s multiple comparison test was used for the analysis of significance between samples. P-values are reported as: *, P < 0.05; **, P <0.01; ***, P <0.001; ****, P <0.0001. Where P-value is not indicated, the comparison between groups is not statistically significant.
Supplementary Figure S4 from Intracellular Osteopontin Promotes the Release of TNFα by Mast Cells to Restrain Neuroendocrine Prostate Cancer
Authors: Sulsenti Roberta , Scialpi Giuseppina B. , Frossi Barbara , Botti Laura , Ferri Renata , Tripodi Irene , Piva Annamaria , Sangaletti Sabina , Pernici Davide , Cancila Valeria , Romeo Francesco , Chiodoni Claudia , Lecis Daniele , Bianchi Francesca , Fischetti Irene , Enriquez Claudia , Crivelli Filippo , Bregni Marco , Renne Giuseppe , Pece Salvatore , Tripodo Claudio , Pucillo Carlo E. , Colombo Mario P. , Jachetti Elena
Published: September 2024

Supplementary Figure S4. Characterization of additional cell lines. A. Immunofluorescence for DAPI (blue) and CGA (red) on murine NEPC cells (TC566 and TC411K). B. Immunofluorescence for DAPI (blue) and OPN (red) on HMC-1 cells. C. Western blot for OPN in HMC-1 cells treated or not with Brefeldin A (BFA; 5 g/ml). Vinculin was evaluated as housekeeping control. D. Gating strategy applied to distinguish human NEPC cells (CD49f+c-Kit-) from HMC-1 MCs (CD49f-c-Kit+) by flow cytometry. E. OPN evaluation by ELISA (left panel) or real time PCR (the Spp1 transcript; right panel) in WT and OPN−/− MCs, and in MC/9, T23, and ST4787 cells. F. Elisa for OPN in parental MC/9 cells and in MC/9-CTR, MC/9-OPNf, MC/9-iOPN cells. T23 cells were used as control.
Table S1 from MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming
Authors: Zewdie Eden Y. , Edwards George M. , Hunter Debra M. , Earp Henry Shelton , Holtzhausen Alisha
Published: September 2024

Supplemental Table 1
Supplementary Figure 9 from Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis
Authors: Castro-Pando Susana , Howell Rian M. , Li Le , Mascaro Marilina , Faraoni Erika Y. , Le Roux Olivereen , Romanin David , Tahan Virginia , Riquelme Erick , Zhang Yu , Kolls Jay K. , Allison James P. , Lozano Guillermina , Moghaddam Seyed J. , McAllister Florencia
Published: September 2024

Supplementary Figure 9: Eomes expression, but not other markers of T-cell Exhaustion, are decreased in KC;IL-17RA fl/fl mice relative to KC mice
Supplementary Figure 2 from A Multicenter Real-life Prospective Study of Axicabtagene Ciloleucel versus Tisagenlecleucel Toxicity and Outcomes in Large B-cell Lymphomas
Authors: Stella Federico , Chiappella Annalisa , Casadei Beatrice , Bramanti Stefania , Ljevar Silva , Chiusolo Patrizia , Di Rocco Alice , Tisi Maria C. , Carrabba Matteo G. , Cutini Ilaria , Martino Massimo , Dodero Anna , Bonifazi Francesca , Santoro Armando , Sorà Federica , Botto Barbara , Barbui Anna M. , Russo Domenico , Musso Maurizio , Grillo Giovanni , Krampera Mauro , Olivieri Jacopo , Ladetto Marco , Cavallo Federica , Massaia Massimo , Arcaini Luca , Pennisi Martina , Zinzani Pier L. , Miceli Rosalba , Corradini Paolo
Published: September 2024

Supplementary Figure 2 – Overall survival tisa-cel vs axi-cel in bridging failure
Figure 4 from Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-Cell Lymphoma
Authors: Meriranta Leo , Sorri Selma , Huse Kanutte , Liu Xiaonan , Spasevska Ivana , Zafar Sadia , Chowdhury Iftekhar , Dufva Olli , Sahlberg Eerika , Tandarić Luka , Karjalainen-Lindsberg Marja-Liisa , Hyytiäinen Marko , Varjosalo Markku , Myklebust June H. , Leppä Sirpa
Published: September 2024

Complementary interactome screening with Kelch-domain coupled proximity-labeling reveals potential substrates of KLHL6 in B-cell context. A, Schematic representation of proximity-labeling (PL) substrate screening with BioID2 approach for C-terminally tagged KLHL6. B, Volcano plot of the DESeq2 model showing the differentially interacting proteins between BioID2-tagged WT KLHL6 and EmGFP constructs showing only the KLHL6-interacting proteins with a positive log2-transformed fold-change (LFC). Colors as in Fig. 3B. C, Comparison of KLHL6 interactomes obtained with the complementary protein interaction screening methods. Evidence for protein binding by APs (“AP-MS”) and proximity-labeling (“BioID2”) are indicated with LFCs of DESeq2 models with respective EmGFP control pull-downs. Labels indicate proteins with strong evidence by both methods and AP/PL-specific interactors not considered common contaminants in mass spectrometry experiments. D, Summary of identified KLHL6 interactors with the complementary screening methods. E, Western blots showing the impact of KLHL6 expression manipulation at the protein levels of BCR components CD79A, CD79B, and IgH (IgM or IgG) in four different cell lines. Below, bar blots show the quantified protein levels of the BCR components in cells with ectopic KLHL6 overexpression (KLHL6 OE) or KLHL6 silencing (KO, knockout; KD, knockdown) normalized to the total protein levels in relation to their respective controls (EmGFP, sgCTRL, or sh_CTRL). F, Western blots showing the impact of KLHL6 expression manipulation on the protein levels of its proximity interactors BANK1 and LuZP1. Heatmaps show the average quantified protein levels from KLHL6 overexpressing or knockout cells normalized to β-actin in relation to the EmGFP- or sgCTRL-transduced cells.
КЛІНІЧНИЙ ВИПАДОК ВТОРИННОЇ АНГІОСАРКОМИ ГРУДНОЇ ЗАЛОЗИ В ЧОЛОВІКА
Authors: НІТЕФОР Л. В.
Published: September 2024

Мета роботи: опис рідкісного клінічного випадку вторинної ангіосаркоми грудної залози в чоловіка.
Частка сарком грудної залози серед сарком усіх локалізацій складає 2,0 %, а серед усіх злоякісних пухлин грудних залоз – менше 1 %. Випадки сарком грудної залози у чоловіків є поодинокими. Тому кожен описаний випадок є цікавим для вивчення. Вторинні ангіосаркоми виникають, як правило, на ґрунті лімфостазу після променевої терапії або хірургічного лікування раку (найчастіше – раку грудної залози). У повідомленні описано клінічний випадок вторинної ангіосаркоми грудної залози в чоловіка; пухлина виникла через 8 років після аксилярної лімфаденектомії, що проводилась з приводу меланоми. Показане значення різних методів діагностики.
El brazo político del campo científico: la Sociedad Brasileña para el Progreso de la Ciencia durante el gobierno de Jair Bolsonaro (2019-2022)
Authors: Scargiali Enzo Andrés
Published: September 2024

The aim of the article is to explain the political intervention of the scientific field in the context of Jair Bolsonaro's government (2018-2022) in Brazil. The article is tributary to the analytical perspective of present-tense historical sociology, based on a temporal conception as a historical category and methodological perspective. In this sense, it analyzes a) the characterization of the right-wing forces in the Bolsonarist government, the main political and economic agents that support it, and the policies promoted for the area of science and technology; b) the social and political dimensions of the organization and political action of the Brazilian scientific field, taking into account its main organization, the Brazilian Society for the Progress of Science (SBPC) and its demands at this juncture in the face of the reduction in funding for the area and violations of academic freedom.  About sources, the participation of SBPC referents and other relevant political and economic agents in the traditional media and in non-traditional spaces, as well as periodical publications in the field of science and technology. As well as periodical publications from the field and the state; official reports and statistical data.
O acordo de não persecução civil - ANPC e seus efeitos sobre o processo administrativo disciplinar – PAD
Authors: Tonelli Júnior Renato Adolfo
Published: September 2024

O trabalho tem por finalidade analisar os contornos legais e requisitos do acordo de não persecução civil – ANPC, incluído na Lei de Improbidade Administrativa (Lei nº 8.429/92) pela Lei nº 13.964/19 e efetivamente detalhado pela Lei nº 14.230/21. Examina as características essenciais do instituto, com ênfase nas sanções da Lei de Improbidade Administrativa passíveis de negociação. Além disso, a partir de exame da legislação, da doutrina especializada e da jurisprudência do Supremo Tribunal Federal e do Superior Tribunal de Justiça, discute se o acordo de não persecução civil – ANPC possui aptidão para produzir efeitos em outras instâncias, notadamente a seara administrativa, sobre processos administrativos disciplinares – PAD.
Effect of two full-fat insect meals, yellow mealworm and black soldier fly larva, on growth performance of juvenile yellowtail
Authors: Ido A. , Takahashi T. , Miura C. , Hirayasu H. , Seyama T. , Miura T.
Published: September 2024

Given the expanding demand for fish meal (FM) worldwide, insect meal has become a promising alternative to FM for sustainable aquaculture. Yellowtail (Seriola quinqueradiata), the predominant farmed fish in Japan, is a carnivorous marine species that requires a substantial quantity of FM in its diet. Two feeding trials were conducted with the aim of assessing the applicability of two full-fat insect meals, yellow mealworm (Tenebrio molitor) meal (TM) and black soldier fly (Hermetia illucens) larvae meal (HI), as FM substitutes in for juvenile yellowtail. In the first trial, replacing 24.3% of FM with TM resulted in a final fish weight of 137.4 ± 40.1 g (mean ± SD as also indicated for subsequent values), comparable to the control group with a weight of 139.5 ± 44.0 g, while maintaining an equivalent level of n-3 fatty acid content across all diets used in the trial. The body weight of fish fed a diet containing HI, at 121.2 ± 31.0 g, was significantly lower than the control group, whereas the difference between fish fed a diet containing TM was not statistically significant. According to the growth analysis, dietary inclusion of TM was more suitable than that of HI, prompting a second trial to evaluate the maximum limit of FM substitution with TM without adjusting fatty acid profiles across diets. In the subsequent trial, fish growth exhibited a clear decrease trend with the inclusion rate of TM. These findings suggest that, while the substitution of FM with HI and TM has been shown to be feasible under equivalent fatty acid profiles in diets, the imbalanced fatty acid profile resulting from the inclusion of full-fat insects could be attributed to a deficiency in n-3 fatty acids, leading to the observed growth retardation in juvenile yellowtail.
Aboriginal Practitioners’ Perspectives on Culturally Informed Practice for Trauma Healing in Australia
Authors: Rodaughan Jessica , Murrup-Stewart Cammi , Berger Emily
Published: September 2024

Colonisation continues to impact Aboriginal children and families through perpetual cycles of transgenerational trauma. To achieve culturally safe and effective healing, practitioners working with Aboriginal people must be culturally competent, yet existing research suggests culturally informed practice (CIP) is often poorly understood and implemented by many practitioners. Centring Indigenous perspectives, the present study explored how Aboriginal practitioners in Australia conceptualise and use CIPs when supporting Aboriginal children and families to heal from trauma. Six Aboriginal women practitioners from mental health and social work settings participated in individual research yarns. Reflexive thematic analysis was used to generate four themes, including centring Aboriginal ways, approaches to healing, creating space for healing, and reflexive and responsive practice. CIPs are embedded within Aboriginal approaches to healing, consider the impacts of trauma and colonisation, and require all practitioners to actively engage with Aboriginal people and their ways of knowing, being, and doing.
“The protective effect of nano curcumin supplementation on doxorubicin induced cardiotoxicity in breast cancer patients; a randomized, double-blind clinical trial”
Authors: Tohidi Mehdi , Allahyari Abolghasem , Ataei Azimi Sajjad , Alimi Hedieh , Elyasi Sepideh , Qoorchi Moheb Seraj Farid , Mehrad-Majd Hasan
Published: September 2024

Background

Anthracycline drugs play a fundamental role in breast cancer treatment; however, the cardiotoxicity side effects obscure the advantages of treatment. Curcumin has antioxidant and anti-inflammatory effects.

Materials and Methods

In this study, we investigated the effect of nanocurcumin supplementation on Doxorubicin induced Cardiotoxicity. In this randomized clinical trial, a week before starting the doxorubicin regimen for breast cancer patients, the control group received placebo and curcumin group received 80 mg daily dosage of nano curcumin capsules for six months. Echocardiography parameter changes before chemotherapy and after six months were evaluated.

Results

46 patients were included. Left ventricle (LV) ejection fraction significantly decreased and LV end diastolic volume significantly increased in control group but no significant changes were observed in the curcumin group (LVEF: 2.62 ± 59.35 to 4.23 ± 56.85, p-value: 0.014 vs 59.55 ± 1.91 to 58.46 ± 3.41, p-value:0.135; LVEDV: 77.09 ± 15.33 to 80.65 ± 14.54, p-value:0.023 vs 72.41 ± 15.34 74.00 ± 14.25, p-value: 0.294). Additionally, LVEF, LV end systolic diameter (LVESD), and end diastolic diameter (LVEDD) insignificantly more decreased in control group versus curcumin group (LVEF: 4.13 ± 2.50- vs 3.36 ± 1.08-, p-value: 0.223; LVESD: 0.27 ± 0.06-vs 0.120.45 ±, p-value:0.110; LVEDD: −0.44 ± 0.33 vs 0.070.33 ±, p-value:0.269). Furthermore, symptomatic cardiomyopathy and ejection fraction ratio less than 53% were not observed. The LVEF reduction >15% was observed was also high in the control group, ( p-value = 0.020).

Conclusion

This study shows the possible effect of nanocurcumin capsules to reduce the cardiotoxicity of anthracycline chemotherapy medications.
Thromboinflammation is associated with clinical outcome after ST-elevation myocardial infarction
Authors: Benkhoff Marcel , Alde Karin , Ehreiser Vincent , Dahlmanns Jana , Metzen Daniel , Haurand Jean M. , Duse Dragos Andrei , Jung Christian , Kelm Malte , Petzold Tobias , Polzin Amin
Published: September 2024

Platelets are crucial in thrombus formation during ST-elevation myocardial infarction (STEMI). In addition, they also play an important role in postischemic thromboinflammation, which is determined by the interplay between activated platelets and neutrophils. The latter form neutrophil extracellular traps, which are detectable in plasma as citrullinated histone H3–deoxyribonucleic acid-DNA complexes. Prediction of the risk of recurrent events is important in precision medicine. Therefore, we investigated whether circulating thromboinflammatory markers predict clinical outcome after STEMI. We performed a prospective, multicentric, observational, all-comer study of patients with STEMI (n = 361). Thromboinflammation, measured as H3Cit-DNA complexes, was assessed on day 1 after presentation with STEMI as well as 5 days and 6 months after STEMI by enzyme-linked immunosorbent assay. Twelve months of clinical follow-up was conducted. Multivariate analysis was performed investigating which variables were independently associated with major adverse cardiac events (MACEs). Patients were aged 64 ± 12 years; 80% were male; and 40% had diabetes mellitus. Thromboinflammation was enhanced during index hospitalization compared with 6-months follow-up (137.4 ± 100.0 μg/L vs 53.7 ± 54.7 μg/L; P < .001). Additionally, patients within the highest tertile of thromboinflammation at day 1 after STEMI showed worse outcome during follow-up (hazard ratio, 2.57; 95% confidence interval, 1.72-3.85; P < .001). Receiver operating characteristic analysis revealed a cutoff value of 219.3 μg/L. In multivariate logistic regression analysis, thromboinflammation was independently associated with outcome after STEMI. To sum it up, thromboinflammation is enhanced in STEMI. It identifies patients at high risk of MACE. Therefore, thromboinflammation might be a promising target and marker in precision medicine. The trial was registered at www.clinicaltrials.gov as #NCT03539133.
Qualitative Comparative Analysis of exercise interventions for fall prevention in residential aged care facilities
Authors: Suen Jenni , Dawson Rik , Kneale Dylan , Kwok Wing , Sherrington Catherine , Sutcliffe Katy , Cameron Ian D. , Dyer Suzanne M.
Published: September 2024

Background

Exercise interventions are highly effective at preventing falls in older people living in the community. In residential aged care facilities (RACFs), however, the evidence for effectiveness is highly variable, warranting exploration of drivers of successful trials. This study aims to identify the conditions of randomised controlled trials (RCTs) that are associated with reducing falls in RACFs and test whether it can explain the variability.

Methods

RCTs testing exercise interventions in RACFs compared to usual care, reporting rate or risk of falls from the 2018 Cochrane Collaboration review and a search update to December 2022 were included. Two authors independently extracted and coded trial conditions and outcomes according to a theory developed from prior Intervention Component Analysis. Trial outcomes were coded as successful or unsuccessful based on point estimates for the rate or risk ratio for falls, or p value. Qualitative Comparative Analysis (QCA), utilising Boolean minimisation theory, was conducted to determine the key conditions driving trial success. A subgroup meta-analysis and the GRADE approach was applied to the final theory.

Results

Eighteen trials undertaken in 11 countries with 2,287 residents were included. Participants were predominately ambulant females aged 70 to 80 with cognitive impairment. Most interventions were fully supervised or supervised at the start of the intervention. QCA identified two configurations as drivers of successful exercise falls prevention programs: (i) group exercise that is moderate or low intensity, or (ii) for independent ambulatory residents, exercise for more than 1 h per week. The combination of configuration (i) and (ii) had consistency and total coverage scores of 1, indicating all trials were explained. This combination was associated with a reduction in falls (rate ratio 0.45, 95%CI 0.34 to 0.59; risk ratio 0.66, 95%CI 0.53 to 0.82; low certainty evidence).

Conclusion

To successfully reduce falls in RACFs, exercise programs should provide continuous supervised moderate-intensity group exercise. For programs that mostly include independent ambulatory residents, exercise for at least 80 min per week should be provided. As many current residents are frail, tailored exercise is likely necessary and an individualised dose may be required. Future trials should test exercise interventions for less mobile residents.
Trial of labour after two caesarean sections (TOLA2C) and risk of uterine rupture, a retrospective single centre study
Authors: Denjean Sonja , Reis Daniela , Bräuer Miriam , Längler Alfred
Published: September 2024

Background

Most German hospitals do not offer a trial of labour after two caesarean sections (TOLA2C). TOLA2C is claimed to be associated with too many complications, above all the high risk of uterine rupture. The objective of this study is to review our experience with TOLA2C, with special attention paid to the risk and probability of uterine ruptures. Secondary outcomes include comparing neonatal and maternal outcomes in the group of TOLA2C with the group of elective repeat caesarean section (ERCS) and to assess the success rate for vaginal birth after two caesarean sections (VBAC-2).

Methods

The retrospective cohort study was conducted in a community hospital in North Rhine-Westphalia. Inclusion criteria were all pregnant women with two caesarean sections in their medical history, with a current vertex singleton pregnancy and the absence of morphological abnormalities of the foetus, who gave birth in our facility between January 2015 and June 2021. Descriptive statistics were calculated and Kolmogorov-Smirnov tests, Mann-Whitney U tests, Fishers exact tests, Chi2 –tests and t-tests for independent samples were performed.

Results

A total of 91 cases were included in the TOLA2C-group. These were compared to 99 cases that, within the same time frame, had an elective repeat caesarean section (ERCS-group). There was no statistically significant difference found in the neonatal outcome between the two groups (except for the neonatal pH-value: p 0.024). The hospital stay was significantly shorter in the TOLA2C-group, while maternal complication rates were almost similar (13.2% in the TOLA2C-Group, vs. 16.2% in the ERCS-Group). The success rate for TOLA2C was 55%. No complete uterine rupture was found, but in three cases an incomplete rupture (3.3% rate for incomplete uterine ruptures) occurred, but had no influence on the neonatal outcome.

Conclusion

TOLA2C is not associated with a worse maternal or neonatal outcome compared to ERCS, and especially the risk of complete uterine ruptures seems to be low. TOLA2C should be more widely offered to suitable patients who are motivated for it.
CCL5 promotes the epithelial-mesenchymal transition of circulating tumor cells in renal cancer
Authors: Guan Yibing , Liu Xueyi , Tian Juanhua , Yang Guang , Xu Fangshi , Guo Ni , Guo Lingyu , Wan Ziyan , Huang Zhixin , Gao Mei , Chong Tie
Published: September 2024

Background

Circulating tumor cells (CTCs) are pivotal in tumor metastasis across cancers, yet their specific role in renal cancer remains unclear.

Methods

This study investigated C–C motif chemokine ligand 5 (CCL5)'s tumorigenic impact on renal cancer cells and CTCs using bioinformatics, in vivo, and in vitro experiments. It also assessed renal cancer patients' CTCs prognostic value through Lasso regression and Kaplan–Meier survival curves.

Results

Bioinformatics analysis revealed differential genes focusing on cellular adhesion and migration between CTCs and tumor cells. CCL5 exhibited high expression in various CTCs, correlating with poor prognosis in renal cancer. In 786-O-CTCs, CCL5 enhanced malignancy, while in renal cell carcinoma cell line CAKI-2 and 786-O, it promoted epithelial-mesenchymal transition (EMT) via smad2/3, influencing cellular characteristics. The nude mouse model suggested CCL5 increased CTCs and intensified EMT, enhancing lung metastasis. Clinical results shown varying prognostic values for different EMT-typed CTCs, with mesenchymal CTCs having the highest value.

Conclusions

In summary, CCL5 promoted EMT in renal cancer cells and CTCs through smad2/3, enhancing the malignant phenotype and facilitating lung metastasis. Mesenchymal-type CTC-related factors can construct a risk model for renal cancer patients, allowing personalized treatment based on metastatic risk prediction.
Comprehensive analysis of an mRNA co-expression network and a ceRNA network reveals potential prognostic biomarkers in oral squamous cell carcinoma
Authors: He Liming , Jiang Zhisheng , Gao Yijun , Zeng Yiyu , Ge Wenhui , Yu Yi , Xie Xiaoyan
Published: September 2024

Background

Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive oral cancer with a poor prognosis. Its polygenic risk is likely influenced by complex transcriptional disorders involving networks of co-expressed and functionally related genes, though such investigations are limited in OSCC.

Methods

We analyzed the GSE37991 dataset, comprising 40 OSCC and 40 normal oral tissue samples from the Gene Expression Omnibus. Tumor-specific modules were identified using weighted correlation network analysis (WGCNA), leading to the selection of hub mRNAs and lncRNAs. These lncRNAs were used to construct lncRNA–mRNA and competing endogenous RNA networks. We further examined the expression profiles and survival data of these genes from the Cancer Genome Atlas. Prognostic markers were identified and validated through 5-year survival analysis and Cox proportional hazards modeling. RT-qPCR was used to validate the expression levels in clinical OSCC tissues.

Results

We identified 1847 differentially expressed genes in OSCC tissues. WGCNA revealed four OSCC-specific modules, screening 120 hub mRNAs and five hub lncRNAs. Two prognostic markers (AQP5, IL-26) from hub mRNAs and three (FRMD5, INHBB, GUCY1A3) from the lncRNA–mRNA network were associated with survival. Validation showed lower expression of AQP5 and GUCY1A3, and higher expression of FRMD5 and INHBB in OSCC compared to normal tissues.

Conclusion

This study enhances our understanding of transcriptional dysregulation in OSCC and may highlights AQP5, IL-26, FRMD5, INHBB, and GUCY1A3 as promising prognostic biomarkers.
Inter-observer reliability and predictive values of triphasic computed tomography for microvascular invasion in hepatocellular carcinoma
Authors: Saleh Gehad A. , Denewar Fatmaelzahraa Abdelfattah , Ali Khadiga M. , Saleh Marwa , Ali Mahmoud Abdelwahab , Shehta Ahmed , Mansour Manar
Published: September 2024

Background

Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor globally and a leading cause of mortality in cirrhotic patients. Our study aimed to estimate the diagnostic performance of triphasic CT and inter-observer reliability in the preoperative detection of microvascular invasion (MVI) in HCC. Two independent radiologists accomplished a retrospective analysis for 99 patients with HCC to assess the CT features for MVI in each lesion. Postoperative histopathology was considered the gold standard.

Results

Multivariate regression analysis revealed that incomplete or absent tumor capsules, presence of TTPV, and absence of hypodense halo were statistically significant independent predictors of MVI. There was excellent agreement among observers in evaluating peritumoral enhancement, identifying intratumoral arteries, hypodense halo, TTPV, and macrovascular invasion. Also, our results revealed moderate agreement in assessing the tumor margin and tumor capsule.

Conclusion

Triphasic CT features of MVI are reliable imaging predictors that may be helpful for standard preoperative interpretation of HCC.
Ιστορία της "κρίσης"
Authors: Περεζούς Κωνσταντίνος
Published: September 2024

Στην διδακτορική μου διατριβή επιχειρώ να παρακολουθήσω την πορεία της «κρίσης» από τον αρχαιοελληνικό λόγο στις εθνικές γλώσσες της νεωτερικότητας. Η ιπποκρατική ιατρική δίνει τεχνικό νόημα στη λέξη, το οποίο παγιώνεται με τη συμβολή του Γαληνού. Το πέρασμα από τα ελληνικά στα λατινικά λαμβάνει χώρα στον ρωμαϊκό ιατρικό λόγο της εποχής, ο οποίος την καθιστά δόγμα καθ’ όλη τη διάρκεια του μεσαίωνα. Στις αρχές της νεωτερικότητας έχουμε μια απο-ιατρικοποίηση της «κρίσης» που συντελείται και στο γενικότερο λόγο της εποχής αλλά και εντός της ιατρικής. Τότε είναι που η «κρίση» αποκτά τη γενικότερη σημασία της κρίσιμης κατάστασης που γνωρίζουμε. Χρησιμοποιώντας παραδείγματα προσπαθούμε να δείξουμε ότι το αργότερο μέχρι τα μέσα του 18ου αιώνα η «κρίση» αποτελεί συνηθισμένο όρο του πολιτικού λόγου. Κλείνουμε παραθέτοντας ορισμένες σύγχρονες προσεγγίσεις της έννοιας της κρίσης.
UV filters in sunscreens
Authors: Στάθη Άννα
Published: September 2024

Τα αντιλιακά προιόντα λειτουργούν ως ενδοκρινικοί διαταράκτες, επηρεάζοντας το ορμονικό μας σύστημα και οδηγώντας μας σε αρνητικές επιπτώσεις για την υγεία.
Delivering the news
Authors: Γεωργακάκης Παναγιώτης
Published: September 2024

Η διατριβή παρουσιάζει την πρώτη αναλυτική έρευνα πάνω στις ουγενοτικές εφημερίδες που εκδίδονταν στη Δημοκρατία των Ηνωμένων Επαρχιών (ή αλλιώς Ολλανδική Δημοκρατία) κατά το τελευταίο τέταρτο του 17ου αιώνα (1671-1701). Οι Ουγενότοι εγκαταστάθηκαν στη Δημοκρατία των Ηνωμένων Επαρχιών ήδη από το 1650 ώστε να ξεφύγουν από τις αυξανόμενες διώξεις εναντίον τους από το γαλλικό κράτος. Κάποιοι από αυτούς τους πρόσφυγες εισήλθαν στην ακμάζουσα ολλανδική τυπογραφική βιομηχανία ενώ άλλοι εργάστηκαν ως ανταποκριτές ή γραφείς στην επίσης ακμάζουσα αγορά νέων. Η παραγωγή εφημερίδων στις Ηνωμένες Επαρχίες καθώς και η κυκλοφορία δυο γαλλόφωνων εφημερίδων από Ολλανδούς εκδότες ήδη από το 1650 βοήθησαν τους Ουγενότους να αποκτήσουν την απαραίτητη εμπειρία στις ειδήσεις. Έτσι, όταν ο αριθμός των γαλλόφωνων αυξήθηκε μετά την Ανάκληση του Εδίκτου της Νάντης, αυτοί οι Ουγενότοι εκδότες αποφάσισαν να δημιουργήσουν τις δικές τους επιχειρήσεις, εκδίδοντας εφημερίδες. Η έκδοση αυτών των εφημερίδων συνυπήρχε με τους συνεχείς πολέμους του Γάλλου βασιλιά Λουδοβίκου 14ου εναντίον της πλειοψηφίας των ευρωπαϊκών κρατών. Όντως, η Γαλλία βρισκόταν σε πόλεμο από το 1672, πρώτα με τους Ολλανδούς στο Γαλλο-Ολλανδικό πόλεμο (1672-1678), μετά απέναντι στις Ισπανικές Κάτω Χώρες και την Αγία Ρωμαϊκή Αυτοκρατορία (1683-1684) που αποτέλεσε το πρελούδιο του πολέμου της Μεγάλης Συμμαχίας (1688-1697) όπου η Γαλλία αντιμετώπισε μια ισχυρή ομάδα ευρωπαϊκών κρατών. Η μονογραφία επιχειρηματολογεί πως κάθε Ουγενότος εκδότης είχε τη δική του ατζέντα, επικεντρωμένος σε μια συγκεκριμένη αγορά, με αποτέλεσμα η συμπεριφορά των εφημερίδων αυτών απέναντι στη Γαλλία και στο βασιλιά της να ποικίλλει.
Altmetric coverage of health research in Ireland 2017-2023: a protocol for a cross-sectional analysis
Authors: Sharp Melissa K , Logullo Patricia , Murphy Pádraig , Baral Prativa , Burke Sara , Grimes David Robert , Ryan Máirín , Clyne Barbara
Published: September 2024

Background Scientific publications have been growing exponentially, contributing to an oversaturated information environment. Quantifying a research output’s impact and reach cannot be solely measured by traditional metrics like citation counts as these have a lag time and are largely focused on an academic audience. There is increasing recognition to consider ‘alternative metrics’ or altmetrics to measure more immediate and broader impacts of research. Better understanding of altmetrics can help researchers better navigate evolving information environments and changing appetites for different types of research. Objectives Our study aims to: 1) analyse the amount and medium of Altmetric coverage of health research produced by Irish organisations (2017 – 2023), identifying changes over time and 2) investigate differences in the amount of coverage between clinical areas (e.g., nutrition vs. neurology). Methods Using Altmetric institutional access, we will gather data on research outputs published 1 January 2017 through 31 December 2023 from active Irish organisations with Research Organisation Registry (ROR) IDs. Outputs will be deduplicated and stratified by their Australian and New Zealand Standard Research Classification relating to ≥1 field of health research: Biological Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Health Sciences, and Psychology. We will clean data using R and perform descriptive analyses, establishing counts and frequencies of coverage by clinical area and medium (e.g., traditional news, X, etc.); data will be plotted on a yearly and quarterly basis where appropriate. Results and Conclusions Improved understanding of one’s information environment can help researchers better navigate their local landscapes and identify pathways for more effective communication to the public. All R code will be made available open-source, allowing researchers to adapt it to evaluate their local landscapes.
The genome sequence of the Streak, Chesias legatella (Denis & Schiffermüller, 1775)
Authors: Lees David ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: September 2024

We present a genome assembly from an individual male Chesias legatella (the Streak; Arthropoda; Insecta; Lepidoptera; Geometridae). The genome sequence is 310.3 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 20.1 kilobases in length. Gene annotation of this assembly on Ensembl identified 15,520 protein-coding genes.