bluuebunny/crossref_metadata_2025 huggingface dataset:
Latent autoimmune diabetes in adults: current data (review of literature and own data)
Authors: Pashkovska N.V. , Tsaryk I.O.
Published: June 2024

The article provides up-to-date information on latent autoimmune diabetes in adults (LADA), presents data on epidemiology, factors and mechanisms of development, clinical features of this disease. The phenotypic variants of the course of LADA are described, the issues of diagnostic features and differential diagnosis are revealed. LADA is a form of diabetes characterized by a less intense autoimmune process and a wide range of clinical signs compared to classical type 1 diabetes mellitus (T1DM) and can have features of both major types of diabetes. Based on the results of epidemiological studies, the prevalence of LADA is approximately 12 % of all cases of diabetes, it is the second most common form of diabetes after type 2 diabetes mellitus (T2DM) and is the most common type of autoimmune diabetes in adults. According to the modern classification, LADA belongs to the autoimmune subtype of T1DM. Since patients do not need insulin at the beginning of the disease, the course of LADA is similar to T2DM, which is the cause of diagnostic errors. The literature data and the results of the conducted research have shown that, in addition to autoimmune damage to pancreatic beta cells, insulin resistance plays a key role in the mechanisms of LADA development, with an increase in the frequency and degree of abdominal obesity, which not only worsens metabolic control and increases the risk of metabolic syndrome, but also causes a decrease in insulin secretion and progression of the autoimmune process. In patients with LADA, the prevalence and degree of obesity, hypertension and dyslipidemia occupy an intermediate position between the classical types of diabetes. Despite having fewer metabolic risk factors compared to T2DM, patients with LADA have the same or even higher risk of death and cardiovascular diseases. The most important diagnostic markers of LADA are levels of C-peptide and autoantibodies against islet antigens. The possibility of a clear diagnosis of LADA is limited due to the significant heterogeneity of the disease due to an overlap of T1DM and T2DM symptoms. According to modern guidelines, therapeutic approaches to LADA, which are based on insulin therapy and metformin, depend on the level of C-peptide. More research is needed to improve personalized approaches to the treatment of this disease.
Gut microbiota changes and novel markers associated with liver steatosis in obese patients
Authors: Moskva Kh.A. , Kikhtyak O.P. , Kondratyuk M.O. , Farmaha M.L. , Leshchuk Ya.L. , Fediaieva S.I. , Leshchuk Ye.S. , Kikhtiak T.A.
Published: June 2024

Background. Liver steatosis is a common condition that can progress to steatohepatitis, fibrosis, and cirrhosis and increases the risk of death from cardiovascular and liver complications. Understanding the link between steatosis and non-alcoholic fatty liver disease, obesity, and gut microbiota is essential. Recent studies have revealed that gut microbiota plays a crucial role in developing this condition, highlighting the importance of microbiota control. The purpose of the study was to detect changes in gut microbiota and new markers associated with hepatic steatosis in obese patients. Materials and methods. The study involved 60 men aged 38 to 65, divided into two groups: 32 patients with hepatic steatosis (experimental group) and 28 with no steatosis (controls). As part of the study, the levels of the lipogram were determined, anthropometric measurements were made, a bioimpedance analysis of the body was performed, as well as liver ultrasound and shear wave elastography. The gut microbiota of all participants was also examined using sequencing techno­logies (material collected from stool samples). Results. In the experimental group, there are significantly more patients with overweight, dyslipidemia (hypercholesterolemia, triglyceridemia, high low-density lipoproteins, high atherogenicity coefficient, and low high-density lipoproteins). Also, patients with hepatic steatosis are more likely to have an excessive percentage of fat and an excessive amount of visceral fat, hepatomegaly due to the craniocaudal size of the liver, and increased liver stiffness. Regarding the intestinal microbiota, there is an increase in bacterial groups belonging to the Bacteroidetes. Our analysis showed that specific markers such as body mass index, blood lipid profile, body fat percentage, and liver ultrasound parameters are essential for diagnosing steatosis. Body mass index above 24.9 kg/m2 and increased waist circumference were associated with steatosis. Bioimpedance analysis parameters, including body fat percentage and relative visceral fat level, were also crucial indicators. Dyslipidemia, with increased levels of total cholesterol, triglycerides, low-density lipoproteins, high atherogenicity coefficient, and lower high-density lipoproteins, was related to steatosis. The liver stiffness was significantly higher among patients with steatosis, indicating additional risk of liver fibrosis. Shear wave elastography can be a valuable tool for detecting liver steatosis. Conclusions. Patients with steatosis were characterized by signs of obesity (increased waist circumference, body mass index) and dyslipidemia, higher percentage of adipose tissue, relative amount of visceral fat, craniocaudal liver size, liver stiffness, and low levels of high-density lipoproteins. An increase in the gut microbiota of bacterial groups belonging to the Bacteroidetes has been observed.
The Development and Innovation of Subject Services in University Libraries under the Background of Artificial Intelligence
Authors: Luo Xinghua
Published: June 2024

This article explores the impact and trends of artificial intelligence technology on the development of subject services in university libraries. It analyzes the current state of application of artificial intelligence technology in library subject services, including intelligent self-service applications, intelligent consultation and knowledge services, personalized services and user profile construction, as well as the construction of intelligent subject service spaces. Innovative strategies are proposed to optimize resource allocation, improve service efficiency and quality, and support teaching and research work.
Evaluate the Sentiment Analysis Performance of Several Classifiers Using Ensemble Feature Selection Method
Authors: Singh Anupriya
Published: June 2024

Abstract: The growing availability of digital text data has sparked a need for effective sentiment analysis methods, which enable the automatic extraction of sentiment from text for various purposes. This study investigates the application of sentiment analysis using the Amazon Reviews Polarity Dataset, a curated compilation of texts categorised into positive and negative attitudes based on review ratings. Despite the dataset containing a substantial amount of labelled data, its narrow focus and classification technique have difficulties in effectively capturing nuanced expressions of sentiment. Using the Amazon Reviews Polarity Dataset as a foundation, this work does a thorough investigation of the performance of several machine learning models for sentiment analysis tasks. We learn a lot about how well different models can detect sentiment patterns by comparing them using a wide variety of performance metrics like recall, accuracy, precision, and F1 score. These metrics include K-Nearest Neighbours (KNN), Random Forest (RF), Logistic Regression (LG), and Ensemble Classifier (ECLF). Logistic Regression stands out as the most effective model, with the Ensemble Classifier coming in a close second, highlighting their promise for practical sentiment analysis applications. These findings emphasise the usefulness of the dataset and the success of the models, showing the crucial significance of careful model selection and evaluation methods in guaranteeing dependable and accurate outcomes in the field of natural language processing applications
Swift Reads: An Online Bookstore
Authors: D R Prajwal
Published: June 2024

Abstract: This research paper discusses the development of an online bookstore using HTML, CSS, JavaScript, PHP, and MySQL with the aim of creating a user-friendly, secure, and efficient platform for purchasing books online. The paper provides a detailed overview of the entire development process, including requirements analysis, system design, implementation, integration, testing, and deployment. Key features of the bookstore include user authentication, book browsing and searching, shopping cart functionality, and order processing, with a focus on security measures to protect user data and ensure safe transactions. The paper concludes with an examination of outcomes, lessons learned, and potential future enhancements to the system, making it a valuable resource for developers and researchers interested in building similar e-commerce websites.
A Review on: Identification of Brain Tumor in MRI Images by the Use of SVM and Fuzzy C-Means Combination
Authors: Maru Harsh
Published: June 2024

Abstract: This work explores a novel approach to accurately identify brain tumors from magnetic resonance imaging (MRI) images by utilizing the complementary capabilities of fuzzy C-Means (FCM) clustering and support vector machines (SVM). Using the soft clustering approach, MRI images are meticulously segregated in the first stage, known as FCM clustering. By giving individual voxels varying degrees of membership, FCM deftly handles the inherent ambiguities and complexity of medical pictures to produce a nuanced representation of tissue kinds. SVM, a potent supervised learning technique for binary classification applications, comes after segmentation. uses this information in the second phase of classification. Through the creation of a hyperplane that divides tumor and non-tumor regions to the greatest extent possible, support vector machines (SVM) are able to optimize the margin between these classes and improve their ability to generalize. We deliberately integrate FCM clustering with SVM classification in order to take use of the complementary characteristics that each of these techniques possesses. While SVM's strong classification skills enable it to fine-tune the identification of tumor regions, FCM's sophisticated segmentation captures the spatial distribution of tissues.
Monitoramento pós-mercado dos testes rápidos para detecção de anticorpos da COVID-19: análise de dados da plataforma Microsoft® Power Bi
Authors: Carvalho Milena Glória , Adati Marisa Coelho , Borges Helena Cristina Balthazar Guedes
Published: June 2024

Introduction: The COVID-19 outbreak caused by a new type of coronavirus was confirmed by Chinese authorities on January 7, 2020, resulting in hundreds of deaths worldwide. Due to the rapid spread of the disease, the World Health Organization (WHO) declared a Public Health Emergency of International Concern on January 30, 2020, and later declared it a pandemic on March 11, 2020. In response to the public health emergency, the National Health Surveillance Agency (Anvisa) in Brazil published Collegiate Board Resolutions (RDCs) No. 379/2020 and RDC No. 445/2020. These regulations established the laboratory analysis of products for in vitro diagnosis by the National Institute for Quality Control in Health (INCQS). Objective: The purpose of this study was to evaluate the performance data of rapid tests for the detection (AcTR) of  COVID-19 antibodies on the Microsoft ® Power Bi platform on the Anvisa portal. Method: The evaluation period was from April 6, 2020, to December 28, 2021. Results: Out of 293 batches of AcTR products evaluated, 55.3% were found to be compliant, while 44.7% were non-compliant according to the established analysis criteria. Conclusions: The main reason for non compliance was reduced sensitivity of the tests. Post-market monitoring was conducted to ensure the availability of quality, safe, and effective products in the Brazilian market and to support decision-making by Brazilian authorities.
THE EFFECT OF MONTMORILLONITE ON THE RHEOLOGICAL AND PHYSICO-MECHANICAL PROPERTIES OF A THERMOSETTING POLYMER COMPOSITE
Authors: Monastyrev Pavel , Elchishcheva Tatiana , Makarchuk Maxim , Erofeyev Vladimir , Rimshin Vladimir , Erofeeva Irina
Published: June 2024

The study investigates a thermosetting polymer filled with montmorillonite. Montmorillonite is a naturally occurring layered mineral with particle sizes ranging from 8 to 12 µm. The thermosetting polymer was DER-330 epoxy resin and FCH-S hardener. Rheological and physical-mechanical studies of the properties of epoxy resin modified with montmorillonite were carried out. Viscosity versus shear rate is shown for uncured pure epoxy resin and resin modified with montmorillonite particles at room temperature. At low shear rates, a significant effect of montmorillonite on the properties of the composite is observed. The low shear rate further allowed epoxy molecules to leak between the layers of montmorillonite platelets, causing swelling and increasing the distance between them. As the shear rate increased from 8 to 20 s-1, the percolation time of montmorillonite decreased, which affected the decrease in viscosity. When the shear rate increases above 20 s-1, no significant changes in viscosity occur; for both samples a monotonic line is observed on the graph. The addition of montmorillonite to epoxy resin changes the chemical composition of the composite, which leads to changes in rheological and physical-mechanical properties. The addition of montmorillonite retards gelation, which can affect processability, cure time, and final properties of the composite. Morphological studies were carried out to determine the degree of dispersion of montmorillonite particles in the polymer composite using a transmission electron microscope. The uneven distribution of montmorillonite particles predominated in all samples. Apparently this is due to the curing conditions of the polymer composite and insufficient dispersion time. Physical and mechanical studies were carried out on samples made of a composite with montmorillonite in comparison with samples from pure epoxy resin. The flexural strength of samples made from the resulting composite is comparable to the strength of samples made from pure epoxy resin. In turn, the viscosity increased by 170%.
FILTRATION REGIME AND STABILITY OF THE EARTH DAM DURING RESERVOIR DRAWDOWN
Authors: Aniskin Nikolay , Stupivtsev Andrey
Published: June 2024

The results of numerical investigations of the filtration regime and stability of an earth dam under reservoir drawdown are considered. The problem of unsteady filtration in a homogeneous earth dam is solved. The parameters of the filtration flow are determined: the position of the depression surface, the values and direction of filtration gradients and flow velocities. The changes in the maximum filtration gradients and the probability of filtration deformations are analyzed. Calculations are made to assess the stability of the upstream slope during the stages of reservoir drawdown with different velocities. It is shown that a dam with a large stability margin when the reservoir is full may lose it and be destroyed in the process of drawdown. Conclusions are drawn about the necessary measures to ensure reliability and safety during operation of the structure.
SOLUTION OF THE PROBLEM OF TWO-DIMENSIONAL THEORY OF ELASTICITY WITH THE USE OF DISCRETE-CONTINUAL FINITE ELEMENT METHOD IN THE PRESENCE OF A CRACK
Authors: Akimov Pavel , Mozgaleva Marina
Published: June 2024

Solution of the problem of two-dimensional theory of elasticity with the use of discrete-continual finite el-ement method in the presence of crack is under consideration in the distinctive paper. The original operational continual and discrete-continual formulations of the problem are given, an example of analysis are presented.
Banjar Cultural Marriage Taboos and Analysis of the Prohibition of Marriage in Kitabun Nikah by Sheikh Muhammad Arsyad Al-Banjari
Authors: Firdaus Zein , Marbawi Muhammad , Afif Muhammad Wildan
Published: June 2024

Marriage is a sunnatullah presented by Allah SWT for the survival of mankind on this earth. Taboo in Banjar culture is a prohibition that is carried out during a wedding procession or before the wedding takes place. In Islam, there is no law against this taboo. This study uses qualitative research with a library approach. The results of the study show that in the Book of Marriage written by Syekh Muhammad Arsyad Al-Banjari, there is no specific prohibition against cultural taboos that exist in Banjar society, but he only explains the prohibition of marriage in Islamic law, such as the prohibition against marrying women of the same lineage, breastfeeding and so on other.
The Problem of Interfaith Marriage in Indonesia: A Juridical-Normative Approach
Authors: Eka Aditya Mochammad Rizky , Khoirunnisa Dinda , Fawwas Fawwas , Qiston Ajid , Azizah Aisyah Zarah
Published: June 2024

Interfaith marriage is a marriage between the bride and groom of different religions and beliefs which is a problem in Islamic law in Indonesia. The regulation regarding the prohibition of interfaith marriage is affirmed in Article 2 paragraph (1) of Law Number 1 of 1974 concerning Marriage. The focus of this study is to analyze the Indonesian legal rules regarding interfaith marriage that are increasingly emerging in Indonesia. The research method uses normative juridical legal methods, data collection techniques namely by analyzing articles, books and references related to the discussion. The results showed that interfaith marriage is not justified in Indonesian legislation with the argument that interfaith marriage is contrary to the religious teachings of Indonesian citizens and can eliminate the basic rights of marriage for husbands, wives and children. As a result of the ban on interfaith marriage, Indonesian citizens are guaranteed legal protection during marriage and after divorce.
Physical Handicap as a Reason for Divorce: Case Study at the Sharia Court, Banda Aceh, Indonesia
Authors: Makinara Ihdi Karim , Ungel Jamhuri , Arrazi Fitrah
Published: June 2024

In the city of Banda Aceh, Indonesia, divorce is permissible in some circumstances including physical infirmities, such as when a husband experiences an erectile dysfunction. Under the Islamic law, divorce is permissible and the woman has the right to initiate divorce proceedings and pursue legal action. This study aims to examine the perspectives of judges at the Banda Aceh Syari'iyah Court regarding divorce cases involving individuals with physical disabilities. This study scrutinizes the practical legal methods employed by analyzing them from the perspective of the Islamic family law principles. This article analyzes the practical legal methods employed by studying the perspectives of the Islamic family law. Conversely, the process of collecting data entails scrutinizing documents, such as legal judgments, pertinent literature, and scholarly papers. According to Hanafi and Malikischolars, divorce due to physical inability is classified as talak ba'in, as determined by this study. Conversely, the Shafi'i and Hanbali schools are seen solely as a means to breach the sacrificial pact (fasakh). If this divorce is determined to be valid, the husband will have two opportunities to legally execute the divorce in order to remarry this woman. According to this, the Banda Aceh Sharia Court concluded that a husband's inability to perform sexually might be considered a valid reason for his inability to fulfill his responsibilities. Testimony from witnesses confirmed this, providing evidence that the legal proceedings adhered to Islamic law. Consequently, this study concludes that divorce occurs when a husband's physical impairment hinders his ability to fulfill his obligations, leading to the breakdown of the marriage. However, the Sharia Court provides a remedy (dispensation) to address the medical condition (impotence) so that the judges might take it into account when seeking reconciliation between the two parties, if the condition is resolved.
Disparity in Judge Decisions in Resolving Rad Inheritance Disputes: Case Study at the Sharia Court in Banda Aceh City
Authors: Hasballah Khairuddin , Mubarrak Dhaiful , Rassanjani Saddam
Published: June 2024

Two contrasting viewpoints emerge over the issue of rad inheritance, notably concerning the events at the Syar'iyah Court. One viewpoint granted Baitul Mal the remaining inheritance, while the other viewpoint maintained that the heirs were entitled to reclaim their remaining assets. This study aims to identify the key elements considered by the justices of the Aceh Syar'iyah Court and the Banda Aceh Syar'iyah Court while making their verdicts in this case, as well as how Islamic law assesses the resolution of inheritance disputes related to property rights. This study scrutinizes the empirical legal research methodologies employed by analyzing them from the perspective of Islamic legal theory. The data is collected by conducting interviews and accessing material in libraries. The findings indicate that the Banda Aceh Sharia Court's Panel of Judges awarded the remaining inheritance to Baitul Mal, in accordance with the book Hasyiyah al-Bajuri, Qanun Number 11 of 2002, and Article 11 paragraph (1), and Article 14 of Aceh Qanun Number 7 of 2004, which pertain to the implementation of Islamic Sharia in the fields of Aqidah, Worship, and Islamic Sharia, and Zakat Management, respectively. Per Article 193 KHI, the justices of the Aceh Syari'yah Court hold a differing opinion regarding the distribution of any leftover inheritance to the heirs of the zawil furudh. According to Islamic family law, Zaid bin Thabit and a few Malikiyah and Syafi'iyah jurists endorse the choice of Baitul Mal to accept the remaining bequest. Furthermore, Uthman bin Affan's viewpoint about the application of rad, which includes marital relations, asserts that all furudhheirs possess the right to rad. This stance is also backed by the ruling of the Panel of Judges of the Aceh Syar'iyah Court.
I Encuentro de Historia de Cantabria
Authors: AA VV
Published: June 2024

Los especialistas en distintas áreas históricas nos ofrecen interesantes perspectivas que nos ayudan a entender el desarrollo de Cantabria, desde las manifestaciones de sus primeros pobladores que dejaron huellas en cuevas y yacimientos arqueológicos, hasta las últimas tensiones y transformaciones ocurridas en nuestra sociedad en la época contemporánea.
Serie supernatural como um novo recurso didático no ensino e aprendizagem nas aulas de geografia
Authors: Calista Antonia
Published: June 2024

O objetivo deste trabalho é mostrar como a serie supernatural pode ser utilizada como recurso didático para o ensino-aprendizagem dos alunos de geografia do ensino médio. A falta de interesse dos alunos pela aula de geografia, faz que, os professores repensem os seus métodos de ensino, sendo assim, a utilização de novos recursos didáticos, novos métodos e metodologias são necessárias para atrair a atenção dos discentes nas aulas de Geografia, assim, o uso da serie Supernatural contribui significativamente nas aulas para conseguir atingir os objetivos das aulas e alcançar interesse e aprendizagem dos discentes. A serie supernatural é assistida pelo público jovem, com mais de 315 episódios e 15 temporadas, a serie aborda diversos conteúdo que pode ser usada nas aulas de geografia. Tendo como objetivos por meio da série supernatural identificar a geografia presente na mesma, além de especificar a importância dos novos recursos didáticos na sala de aula e conhecer os principais conteúdos didáticos abordado na série supernatural.
Experiencia en miotomía endoscópica peroral en un centro de Bogotá, Colombia, entre 2018 y 2022
Authors: Barragan Briceño Tatiana P , Gonzalez Ausique Paola Stephany , Fuentes Díaz Carlos Fernando , Rodríguez Fajardo Jesús Antonio , Gomez Ayala Maria Camila
Published: June 2024

Antecedentes: la acalasia es una enfermedad de baja incidencia, pero que afecta significativamente la calidad de vida de los pacientes. El tratamiento de elección ha sido la miotomía de Heller, pero en 2010 se describió la miotomía endoscópica peroral (POEM) y desde entonces ha tenido amplia difusión por su efectividad y seguridad.
Objetivo: describir los resultados de la cohorte más grande hasta la fecha en Colombia, en pacientes con acalasia tratados con cirugía endoscópica, con la técnica POEM.
Métodos: estudio observacional de cohorte que incluyó pacientes manejados con miotomía endoscópica peroral en la ciudad de Bogotá, Colombia, entre 2018 y 2022. Se recolectó y analizó retrospectivamente la información de las historias clínicas, y prospectivamente el posterior seguimiento telefónico. Se utilizó la escala de Eckardt prequirúrgica y en los seguimientos para establecer el éxito clínico.
Resultados: entre 2018 y 2022 se intervino a 31 pacientes, de los cuales el 61% eran hombres, y la media de edad fue de 47 años. Se obtuvo éxito técnico en el 97% de los casos y éxito clínico, con un puntaje de Eckardt menor o igual a tres, en el 93% a los dos meses de seguimiento. El 45% de los procedimientos fueron ambulatorios y la tasa de complicaciones fue del 10%.
Conclusión: nuestro estudio muestra que la miotomía endoscópica peroral para manejo de acalasia es una técnica efectiva, con baja tasa de complicaciones y segura para realizarse ambulatoriamente.
Positive outcome of a twin pregnancy after the administration of tocilizumab to a pregnant woman with severe COVID-19
Authors: Dickov Isidora , Bulatovic Sanja , Petrovic Djordje , Antic-Trifunovic Ksenija , Krsman Anita
Published: June 2024

Introduction. Tocilizumab is an IgG1 monoclonal antibody targeting the interleukin 6 receptor. We present a case of a pregnant woman with COVID-19 pneumonia, which rapidly worsened despite the advanced treatment. Therefore, the administration of tocilizumab was deemed necessary. Case outline. Our patient was a 31-year-old pregnant woman hospitalized on the seventh day after contracting COVID-19. She was in the 21st week of a twin pregnancy, specifically monochorionic diamniotic. Her general condition was severe, accompanied by elevated inflammation markers: C-reactive protein ? 94.6 (mg/L), procalcitonin ? 1.44 (ng/mL), and IL-6 ? 79.3 (pg/mL), along with extensive bilateral pneumonia evident in the X-ray image. She required respiratory support in the form of high flow nasal cannula, continuous positive airway pressure, and intensive monitoring. The following day, her condition deteriorated further, prompting the decision to administer tocilizumab. After receiving tocilizumab, the X-ray image deteriorated, but the inflammation markers decreased. After 33 days of hospitalization, she was discharged with normal laboratory findings and a clear X-ray. On July 16, the patient was admitted to the Clinic for Gynecology and Obstetrics of the Clinical Center of Vojvodina at 36 weeks of gestation (35 gw + 2 day) due to premature contractions. On the same day, a caesarean section was performed, and both neonates were in good general condition. Conclusion. Managing severe COVID-19 in pregnant women poses significant challenges. This case study suggests that tocilizumab may hold efficacy in treating this condition.
SGLT2 Inhibitor Dapagliflozin Increases Skeletal Muscle and Brain Fatty Acid Uptake in Individuals With Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Positron Emission Tomography Study
Authors: Latva-Rasku Aino , Rebelos Eleni , Tuisku Jouni , Aarnio Richard , Bhowmik Achol , Keskinen Helmi , Laurila Sanna , Lahesmaa-Hatting Minna , Pekkarinen Laura , Isackson Henrik , Kirjavainen Anna K. , Koffert Jukka , Heurling Kerstin , Nummenmaa Lauri , Ferrannini Ele , Oldgren Jonas , Oscarsson Jan , Nuutila Pirjo
Published: June 2024

OBJECTIVE

The aim of this study was to investigate the impact of the sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin on tissue fatty acid (FA) uptake in the skeletal muscle, brain, small intestine, and subcutaneous and visceral adipose tissue of individuals with type 2 diabetes by using positron emission tomography (PET).

RESEARCH DESIGN AND METHODS

In a 6-week randomized double-blind placebo-controlled trial, 53 patients with type 2 diabetes treated with metformin received either 10 mg dapagliflozin or placebo daily. Tissue FA uptake was quantified at baseline and end of treatment with PET and the long-chain FA analog radiotracer 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid. Treatment effects were assessed using ANCOVA, and the results are reported as least square means and 95% CIs for the difference between groups.

RESULTS

A total of 38 patients (dapagliflozin n = 21; placebo n = 17) completed the study. After 6 weeks, skeletal muscle FA uptake was increased by dapagliflozin compared with placebo (1.0 [0.07, 2.0] μmol ⋅ 100 g−1 ⋅ min−1; P = 0.032), whereas uptake was not significantly changed in the small intestine or visceral or subcutaneous adipose tissue. Dapagliflozin treatment significantly increased whole-brain FA uptake (0.10 [0.02, 0.17] μmol ⋅ 100 g−1 ⋅ min−1; P = 0.01), an effect observed in both gray and white matter regions.

CONCLUSIONS

Six weeks of treatment with dapagliflozin increases skeletal muscle and brain FA uptake, partly driven by a rise in free FA availability. This finding is in accordance with previous indirect measurements showing enhanced FA metabolism in response to SGLT2 inhibition and extends the notion of a shift toward increased FA use to muscle and brain.
Application-Based Assembled Edu Media to Stimulate Early Childhood Alphabet Recognition Abilities
Authors: Sari Luh Julia , Handayani Dewa Ayu Puteri
Published: June 2024

Currently, the only learning media available are books and letter posters which are used to learn to recognize letters, so that in developing aspects of language development, one of them is that children's language literacy is less than optimal. Research and development of assemblr edu media in stimulating alphabet recognition ability for early childhood children. The purpose of this study was to determine whether the design and development of the educational media assembly was appropriate for stimulating the ability to recognize letters in kindergarten. This study stimulate the ability to recognize letters in early childhood children with attractive digital media. The model used was ADDIE. The instrument used to collect data was a questionnaire. The validity test of this assessment instrument was carried out through content validity testing (expert/expert test). The developed instrument will be tested by two media experts, two material experts, and ten student responses. Based on the validity test by two experts, the instrument validity value = 1 was obtained, which stated that the validity of this media instrument has a very high criterion and is worthy of use. Whereas Based on the results of the media expert validity analysis, a score of 93.18% was obtained, the material expert validity result obtained a score of 100 and the child response trial obtained a score of 97.5%. So that this research is "Valid" with a very good qualification and is worthy of stimulating the ability to recognize letters in early childhood children.
Profil Hasil Belajar Mahasiswa Pendidikan Matematika pada Materi Sistem Persamaan Linear dan Matriks Mata Kuliah Aljabar Linear
Authors: Siregar Hesty Marwani
Published: June 2024

Linear Algebra is one of the mathematical subjects that students majoring in Mathematics Education need to master, as it has connections with other fields, other mathematical topics, and plays a role in solving everyday life problems. Previous research indicates that the achievement of learning outcomes in Linear Algebra still needs further optimization. Therefore, this research was conducted with the aim of assessing the achievement of learning outcomes in Linear Algebra, specifically in the topics of Systems of Linear Equations and Matrices. This research utilized a qualitative descriptive research method. Data was collected through a linear algebra test comprising four questions related to Systems of Linear Equations (SLE) and matrices. Subsequently, the percentage of student learning outcomes achievement for each question and the total score were calculated and interpreted. The results of this study indicate that the overall learning outcomes of students fall into the moderate category with a percentage of 50.51%. When examining each individual question, three questions fall into the moderate category, while one question falls into the high category.
Pengaruh Model Project Based Learning Dengan Media Audio Visual Terhadap Hasil Belajar Matematika Peserta Ddidik Kelas V SD
Authors: Destini Frida , Muncarno Muncarno , Astuti Nelly , Lolyana Lolyana , Profithasari Nindy , Irsyadina Hida Laila
Published: June 2024

The problem in this study is the low mathematics learning outcomes of V grade students at SD Negeri 1 Bandar Agung. This study aims to determine the effect of using a project based learning model with audio visual media on the mathematics learning outcomes of fifth grade students. This type of research is quantitative research with an experimental approach. type of quasi-experimental method (quasi experiment design) with the form of Non-equivalent Control Group Design. The population and sample in this study were all V grade students at SD Negeri 1 Bandar Agung, totaling 54 students. Data collection techniques were carried out using multiple choice tests and non-tests in the form of observation and documentation studies. The data analysis technique uses a simple linear regression test. The results of calculations to test the hypothesis through a simple linear regression test show that Ha is accepted, which means that there is an effect of using the project based learning model with audio-visual media on the mathematics learning outcomes of grade V students at SD Negeri 1 Bandar Agung.
Physical and Chemical Analyses of Shabu Clay for Stoneware Ceramics Production
Authors: Okewu E. Jonathan , Ovye Asheadzi Godwin , Wombo Ngunan Patience
Published: June 2024

This is an experimental study that has ascertained the quality of a ceramic raw material discovered in economic value quantity in Nasarawa state, located in the middle belt region of Nigeria. Shabu settlement in the Lafia local government area of Nasarawa State, Nigeria, is the point of concern. This location has one of the largest deposits of secondary clay in the region. The advent of an art school at the Federal University of Lafia, where ceramics is offered as a course of study, has further brought this material of economic value to the limelight for use in ceramics production. For sustainable use in stoneware ceramics production and also in future industrial applications, it is necessary that Shabu clay be carried through the necessary physical and property tests to confirm what type of secondary clay it truly is in terms of chemical analysis, plasticity, shrinkage, throwing ability on the potter’s wheel and firing tests. Shabu clay was conducted through all the forgoing tests, and the findings indicate that Shabu clay contains basic oxides that are worthy of being a good working clay but have percentages of oxides that are not the same as any other clay. The plasticity test shows that the clay is plastic enough for good production processes that include hand building, throwing and slip casting. Shrinkage tests indicate higher than recommended shrinkage for good stoneware ceramics production, and as such, Shabu clay will need to be improved upon by adding Kaolin to the body to balance up the shrinkage rate. The throwing test conducted confirmed that Shabu clay had the required strength for throwing and withstood forming and pulling. Finally, Shabu clay, under two different firing tests of earthenware and stoneware temperatures, showed no sign of deforming and melting. This implies that the clay can conveniently be used for stoneware ceramics production.
Ukazovatele daňovej a regulačnej konkurencieschopnosti: aké daňové zaťaženie a vyvolané náklady znášajú podniky v krajinách EÚ?
Authors: Huňady Ján , Demeová Elenóra
Published: June 2024

The tax burden and induced costs of regulation may affect the competitiveness of the economy and, in the context of current digital transformation trends, determine the ability of businesses to compete in terms of digital readiness. Regulatory competitiveness is very closely linked to the quality and performance of country’s public institutions. This paper examines the tax and regulatory burden on businesses in EU countries and assesses the tax and regulatory competitiveness of the business environment in these countries. The research is mainly based on an empirical analysis of secondary data. On the basis of selected indicators of the tax and regulatory burden on businesses obtained from the World Bank’s database (Doing Business), we examine the situation in EU countries. We use the method of a hierarchical and non-hierarchical cluster analysis to categorize countries into relatively homogeneous groups. According to our results, Slovakia has a similar level of tax and regulatory competitiveness as the Czech Republic and Portugal. Furthermore, we evaluate Slovakia’s strengths and weaknesses in international comparison. The results show, among other things, that the financial costs of administrative tasks required due to business regulations are relatively low in Slovakia. On the other hand, the time to complete administrative tasks is long and the tax burden on businesses is relatively high in Slovakia.
KI in Gesundheit und Pflege
Authors: Swoboda Walter
Published: June 2024

Zu Risiken und Nebenwirkungen fragen Sie Ihre KI

Künstliche Intelligenz durchdringt alle Bereiche des Lebens - auch das Gesundheitswesen. Walter Swoboda zeigt in seinem Buch, wie KI funktioniert, welche Varianten dieser neuen Technologie in Gesundheit und Pflege zum Einsatz kommen können und welche Einsatzgebiete sich kurz- und langfristig ergeben. Auf Chancen, Risiken und ethische Herausforderungen geht er ein. Auch experimentelle Verfahren der Zukunft berücksichtigt er.
Das Buch richtet sich an Praktizierende, Forschende und Studierende in den Bereichen Gesundheitswesen, Gesundheitsmanagement, Gesundheitsinformatik, Medizin, Pflegewissenschaften sowie Medizinethik.
Reconceptualizing the Marriage Age Limit in Indonesia: Efforts to Strengthen Family Resilience in North Sumatra
Authors: Iwan  , Fatimah  , Betawi Usman , Nasution Muhammad Iqbal Hanafi
Published: June 2024

The issue of early marriage has become a polemic and still occurs frequently in Indonesian society. This paper considers the importance of limiting the age of marriage to prevent negative physical, social and emotional impacts on children. This paper abstracts how early marriage in Indonesia impacts family resilience. This type of research is field research, with a text analysis approach related to social issues to answer related factors that influence early marriage and how to improve family resilience. The author conducted research by interviewing five people, one of whom is the deputy head of the Religious Court, the other four are actors who play the role of parents in fulfilling the economical and social needs of children in low-income families, the impact of the increase in the marriage age limit on the rise in marriage dispensation applications at the Indonesian Religious Court, irregularities in marriage dispensation, the phenomenon of underage marriage, the practice of nikah sirri and its implications for marriage registration in Indonesia. The results show the need for better education, economic access, substantial law enforcement, and changes in social and cultural norms to address early marriage, concluding that limiting the age of marriage is vital to achieving family stability, happiness and well-being in Indonesia.
РЕФОРМА ЗДРАВООХРАНЕНИЯ В РОССИИ: АВТОРИТЕТНЫЕ МНЕНИЯ
Authors: Тихомиров Алексей
Published: June 2024

Проанализированы наиболее существенные предложения авторитетных ученых по реформе здравоохранения в России. Показано, что они не имеют возможности реализации без учета основополагающих факторов. Проблема реформы и проблема видения проблемы реформы – разные вещи. Нужен другой подход, другой ракурс взгляда на проблему, другая доктрина. Требуется не набор отрывочных разрозненных концептов, а единая цельная концепция организации охраны здоровья в стране с отказом от сохранения любых элементов модели Семашко.
Стохастическая интерпретация дифракции частиц на кристалле
Authors: БатановГаухман Михаил
Published: June 2024

В данной работе на основании анализа формулы (2.2) для расчета диаграмм упругого рассеяния микрочастиц на многослойной поверхности кристалла, выведенной автором в статье [3], показано, что стохастический подход к решению задачи рассеяния элементарных частиц на кристаллах может послужить альтернативой гипотезе Луи де Бройля о волновых свойствах материальных частиц. Представленные в данной работе результаты расчетов по формуле (2.2) хорошо согласуются с экспериментально полученными электронограммами и рентгенограммами и опытами К. Дэвиссона и Л. Джермера
Socio-Economic Role of Jwalamukhi Temple, Dist.Kangra, Himachal Pradesh
Authors: Kumar Rakesh , Parmar Prof. (Dr.) Dharamjit Singh
Published: June 2024

Jwalamukhi temple is the place of one of the fifty-one Shaktipeethas of Maa Durga. The temple plays an important role in the socio-economic conditions of the state. The temple along with an important hub of religious activities has been a significant place of social and economic activities which with the passage of time have increased both in degree and nature. The present paper seeks to look into the socio-economic role of the Jwalamukhi temple both in the lives of the people of the area and also in the state of Himachal Pradesh.
Implementasi Asas Tata Ruang Wilayah Dalam Penataan Komplek Perkantoran Terpadu Di Kabupaten Boyolali
Authors: Suwarno Natalia
Published: June 2024

Wilayah Komplek Perkantoran Terpadu mencakup kantor- kantor unit kerja perangkat daerah di Kabupaten Boyolali. Tujuan dari pembangunan komplek perkantoran terpadu untuk memudahkan akses masyarakat ke kantor pemerintahan dan meningkatkan efisiensi layanan, karena sebelumnya kantor- kantor tersebut tersebar dengan jarak yang cukup jauh satu sama lain. Merancang komplek perkantoran terpadu perlu adanya analisis peranan asas tata ruang wilayah. Menurut regulasi mengenai penataan ruang, beberapa aspeknya adalah pemanfaatan ruang untuk semua kepentingan secara terpadu, berdaya guna dan berhasil guna, serasi, serta seimbang dan berkelanjutan. Kondisi perkantoran di Kabupaten Boyolali sebelum tahun 2010 tersebar mulai dari daerah Penggung sampai Mojosongo, sehingga dalam pelayanan terhadap masyarakat dirasa kurang efektif. Relokasi menjadi salah satu peranan penting dalam melakukan penataan ruang wilayah yang merupakan pemindahan lokasi dari persebaran kantor yang ada di Kabupaten Boyolali ke kawasan komplek perkantoran terpadu. Titik perkembangan pembangunan pada daerah ini yaitu mewujudkan pembangunan  komplek  perkantoran  baru  di  Kabupaten  Boyolali,  sehingga  antar masyarakat dan pemerintah bisa lebih bersinergi. Penelitian ini menggunakan metode penelitian kualitatif survei yang dicapai dengan melakukan observasi langsung ke lokasi dan melakukan perekaman data melalui dokumentasi dan studi kepustakaan. Tujuan dari penelitian ini adalah mengetahui bagaimana asas penataan ruang wilayah dapat terimplementasikan dalam penataan Komplek Perkantoran Terpadu di Kabupaten Boyolali.
Understanding the institutional change and organizational transformation: An exploratory analysis of Indonesian higher education
Authors: Andriana Isni , Suppiah Susela Devi , Yulianita Anna , Thamrin K. M. Husni , Bashir Abdul
Published: June 2024

This study aims to analyze, investigate the implications, and identify differences in the progress of the effect of institutional changes and organizational transformation in Indonesian higher education. The structuration analysis shows that examining the conditions that have resulted in the replication and modification of social systems is the focus of the structuration analysis. The image of structuration theory conveys both a sense of regularity and continuity, as well as respect for the labor that must be done daily and the mundane but essential tasks that must be completed. The finding of this study is that with the mandate that universities have been given to implement the three primary pillars that support Indonesia’s higher education system, the difficulty level of the problem facing Indonesia’s higher education system has increased. We suggest a future research agenda and highlight the changes and transformations in power, interests, and alliances that affect the evolution of higher education institutions.
DSM: una perspectiva hegeliana de la clasificación en psiquiatría
Authors: Amador Rivera Gonzalo
Published: June 2024

La psiquiatría  a lo largo de su historia y fundamentalmente desde la publicación del DSM-5, enfrenta diversas críticas por la falta de confiabilidad y validez en las clasificaciones de los trastornos mentales, esto  debido a su incapacidad para integrar adecuadamente el conocimiento científico y  la complejidad de las experiencias individuales. Este análisis, inspirado en la filosofía de Hegel, propone una nueva perspectiva que valora cada caso clínico como una entidad única, desafiando el enfoque reduccionista y promoviendo un entendimiento más profundo y respetuoso de la psicopatología, enriquecido con una integración dialéctica del conocimiento científico y el concepto del universal concreto.
Contingencia, práctica y pensamiento político en Leibniz
Authors: De Salas Ortueta Jaime
Published: June 2024

¿En qué medida la actividad política de Leibniz se apoya en unos principios metafísicos? Para responder a esta pregunta debemos entender que en Leibniz se da una práctica, es decir una actividad donde los elementos propiamente filosóficos se entremezclan con una visión de la coyuntura que posibilita, exige y limita la acción política. La Metafísica leibniziana es afín a la práctica política del propio Leibniz. Esto se estudia en el articulo atendiendo a los conceptos de contingencia y de libertad, y a las dos formas en que las verdades de hecho remiten a las verdades de razón: En tanto que manifestaciones de la sustancia y en tanto que hechos o acontecimientos que se ajustan a leyes. En la medida en que el pensamiento leibniziano se atiene a la sustancia se perfila un concepto de acción que se ajusta a una visión ejemplarista del hombre como imagen de Dios mientras que desde el segundo punto de vista Leibniz reformula la noción de Ley de la naturaleza como fundamento del derecho. Desde este punto de vista hay que valorar los tres grados de la justicia que Leibniz distingue.
Toxic dispossession and environmental violence in Latin America
Authors: Vélez-Torres Irene , Lugo-Vivas Diego Andrés , Swistun Débora A.
Published: June 2024

The emission of pollutants from industrial, extractive (mining and hydrocarbons), and corporate agricultural activities exacerbates environmental degradation, endangering sustainable living conditions for humans and more-than-humans. Growing concerns revolve around the chronic and acute exposure to hazardous substances, often leading to compounded, cumulative, and irreversible consequences in socio-ecosystems and human health. Yet, resorting to the anthropogenic origins of socio-ecological damages resulting from widespread contamination does not fully elucidate the intricate biopolitical and geopolitical dynamics underlying the intoxication of cuerpxs-territorixs [bodies-territories]. This Special Section comprises five articles that leverage existing scholarship in political ecology and related fields to critically analyze the political ecologies of toxic dispossession, socio-ecological degradation, and forced environmental changes driven by extractivism. Drawing on the analysis of different cases from Latin America, the authors elucidate how environmental violence, toxic dispossession, and environmental suffering root in the extractive and predatory models rooted in colonial legacies, unresolved racial, ethnic and gendered inequalities, and the expansion of contemporary capitalism in the Global South.