bluuebunny/crossref_metadata_2025 huggingface dataset:
(112) PELVIC FLOOR MUSCLE TRAINING IMPROVES SEXUAL FUNCTION AND DIMINISHES SEXUAL DISTRESS IN WOMEN WITH MULTIPLE SCLEROSIS
Authors: Athanasios Zachariou , Vagia Sapouna , Ioannis Giannakis , Aris Kaltsas , Prof. Fotios Dimitriadis , Prof. Athanasios Papatsoris , Prof. Panagiota Tsounapi , Prof. Charalampos Mamoulakis , Prof. Atsushi Takenaka , Prof. Nikolaos Sofikitis
Published: July 2023

Objectives

Pelvic floor muscle training (PFMT) contributes to better sexual function, as their strength and ability to properly contract improves vaginal receptivity and responsiveness, orgasm and sexual pleasure. Multiple sclerosis (MS) is the most common chronic nervous system disorder leading to sexual dysfunction, with a prevalence of 40-70%. The primary outcome of this study was to evaluate the effect of PFMT on improving sexual function and sexual distress in women suffering from MS.

Methods

In this randomized controlled trial, 30 women suffering from MS were randomly included in an intervention Group A (12 weeks PFMT), and 30 women were randomly included in a control Group B (observation group; negative control group). All women were assessed with the Female Sexual Function Index (FSFI) and Female Sexual Distress Scale-Revised (FSDS-R) at the study's beginning and end. Statistical analysis was performed using a Chi-square test.

Results

Differences in baseline sexual function and distress variables were not significant between groups A and B (P>0.05). At the end of the twelve-week period, there was a statistically significant improvement in nearly all domains of FSFI and FSDS-R in Group A compared with Group B. Women with PFMT (Group A) displayed higher statistically significant results (p<0.05) in desire (Group A: 3.54+0.18 vs Group B: 2.94+0.15), arousal (4.33+0.36 vs 3.92+0.47), orgasm (4.91+0.52 vs 3.93+0.29), satisfaction (5.01+0.56 vs 3.96+0.29), lubrication (4.81+0.36 vs 3.82+0.34), total FSFI score (27.14+1.17 vs 22.71+0.91) and FSDS-R score (7.35+4.51 vs 9.23+4.62). There was no statistically significant difference in the pain domain. Seven women in Group A and none of the women in Group B reported that their sexual difficulties were resolved at the end of the trial period.

Conclusions

Pelvic floor muscle training can enhance sexual function and diminish sexual distress in women with MS.

Conflicts of Interest

Conflict of interest: none
(170) ACUTE STRESS DISORDER DURING LABOR IS A PREDICTOR OF POST-PARTUM DYSPAREUNIA
Authors: Dr. Anna Padoa , Dr. Roni Tomashev , Dr. Inbal Brenner , Ayelet Golan , May S Igawa , Dr. Ido Lurie , Dr. Yael Reicher , Anat Talmon , Prof. Karni Ginzburg
Published: July 2023

Objectives

Few studies have addressed the relationship between peri-partum emotional parameters and post-partum dyspareunia. The aim of this study was to assess the prediction of dyspareunia 3 months postpartum by obstetrical outcomes, perceptions of childbirth experience and emotional adjustment immediately following childbirth. [if !supportLineBreakNewLine] [endif]

Methods

Four-hundred and forty women were recruited within 48 hours postpartum (T1) in the maternity ward from April 2018 to August 2020. Self-report questionnaires were administered at T1 and again 3 months postpartum (T2), addressing demographic and reproductive background, pre-partum dyspareunia, pain during labor, perceived threat, sense of control and acute stress disorder (ASD) during labor. Obstetrical information was retrieved from clinical files. [if !supportLineBreakNewLine] [endif]

Results

Two-hundred and sixty-three women filled the dyspareunia questionnaire at both T1 and T2. Of those, 237 (91.2%) reported having sex since childbirth (T2); 47 women (17.9%) were classified into the pre-partum dyspareunia, and 60 women (22.8%) as post-partum dyspareunia. Of the dyspareunia group at T2, 40% (n = 24) were also classified into the dyspareunia group at T1. Dyspareunia severity at T1 and T2 were moderately correlated (r = .39, p < .001). Women with post-partum dyspareunia (group 1) and women without post-partum dyspareunia (group 2) were compared for demographic, obstetrical and emotional parameters. Demographic data were similar between groups. Dyspareunia was not related to pain during childbirth. Women in the post-partum dyspareunia group reported more birth-related ASD symptoms, than comparisons. ASD symptoms at T1 predicted dyspareunia severity at T2 (B = .81, SE = .26, p= .002) after controlling for participants’ age, birthweight, pain during childbirth, and dyspareunia severity at T1.

Conclusions

ASD immediately after labor is a predictor of postpartum dyspareunia. Peripartum caregivers should be cognizant of this association, addressing ASD symptoms in the immediate postpartum period and assessing for sexual wellness in women after childbirth.

Conflicts of Interest

Anna Padoa: Pierre Fabre Group- speaker honorarium ESSIC- board member
(65) PSYCHOSEXUAL DEVELOPMENT, SEXUAL FUNCTIONING AND SEXUAL SATISFACTION IN LONG TERM CHILDHOOD CANCER SURVIVORS: DCCSS-LATER 2 SEXUALITY SUBSTUDY
Authors: Cristina Priboi , Dr. Marloes van Gorp , Dr. Heleen Maurice-Stam , Prof. Gisela Michel , Prof. Leontien Kremer , Prof. Wim Tissing , Dr. Jacqueline Loonen , Dr. Helena van der Pal , Dr. Andrica de Vries , Prof. Marry van den Heuvel-Eibrink , Dr. Cécile Ronckers , Dr. Dorine Bresters , Marloes Louwerens , Dr. Sebastian Neggers , Margriet van der Heiden-van der Loo , Prof. Eline van Dulmen-den Broeder , Prof. Martha Grootenhuis
Published: July 2023

Objectives

Childhood cancer may negatively impact childhood cancer survivors’ (CCS) sexuality. However, this is an understudied area of research. Our study aimed to describe the psychosexual development, sexual functioning and sexual satisfaction of CCS, compare these outcomes to the Dutch population and identify determinants for CCS’ sexuality.

Methods

From the Dutch Childhood Cancer Survivor Study LATER cohort (diagnosed 1963-2001), 1912 CCS (18-71 years, 50.8% male) completed questions on sexuality, psychosocial development, body perception, mental and physical health. Sexuality of CCS age 18-24 was compared to the general Dutch population using binominal tests and t-tests. Multivariable regression analysis was used to identify determinants.

Results

Compared to general population peers, CCS age 18-24 showed significantly less experience with masturbation (p=.045), French kissing (p=.007), petting under clothes (p=.001), oral (p=.008) and anal sex (p=.016). No significant differences were found for problems with sexual functioning and sexual satisfaction neither among female CCS nor male CCS when compared to peers age 18-24. One third of all CCS reported hindered sexuality due to childhood cancer, with body dissatisfaction most often mentioned reason (44.8%). The regression analysis identified older attained age, body perception, lower mental health and surviving central nervous system tumors as determinants for reduced sexuality.

Conclusions

CSS reported less psychosexual development, but similar sexual functioning and sexual satisfaction compared to the general population. We identified determinants for sexuality, which could be integrated in specific communication training for health professionals and development of clinical interventions for CSS with reduced sexuality.

Conflicts of Interest

No conflict of intrest.
(343) PERCEPTIONS OF SEXUAL BOREDOM IN A COMMUNITY SAMPLE
Authors: Leonor de Oliveira , Prof. Joana Carvalho , Prof. Pedro Nobre
Published: July 2023

Objectives

Although sexual boredom is a common concern, there seems to be a gap in the overall research and, specifically, concerning this construct’s meaning for different people. This work aimed to explore the definitions of sexual boredom in a large community sample of Portuguese individuals.

Methods

Data were collected between September 2019 and February 2020 and constitute a secondary use of data from a larger quantitative online study. After completing the survey, participants were directed to a non-mandatory, open-ended item asking: “What is sexual boredom for you?”. The present study refers to the answers given to this item. From the 927 total respondents to the survey, 653 answered to the open-ended item. Participants ages varied between 18 to 75 years old (M = 33.14; SD = 9.01) and had multiple genders, sexual orientations, and relationship types. Following this, was conducted a thematic analysis with NVivo 12 PRO software of the participants’ written responses using Braun and Clarke’s foundational guidelines.

Results

Three main themes were identified: definitions of sexual boredom, predisposing and maintenance factors of sexual boredom, and managing of sexual boredom. Sexual monotony, sexual desire, and hedonic value stand out as defining features of sexual boredom. Participants referred to individual (cognitive, emotional, and physical factors), interpersonal (partner and relationship factors), and practice related facets, and suggest different paths in and out of sexual boredom.

Conclusions

Sexual boredom is a multidimensional construct that is not captured by most research. Based on this thematic analysis, sexual boredom can be defined as the perception of monotonous or unpleasurable sexual activity or of lack of sexual interest, related to individual, relationship, or practice aspects of sexual relationships, and which may lead to exploring sexual novelty or to the progressive waning of sexual desire. Findings have clinically implications and indicate the need of a multidimensional measure of sexual boredom.

Conflicts of Interest

No conflicts of interest to declare.
(67) PORNOGRAPHY AND SEXUAL SATISFACTION IN RELATIONSHIPS
Authors: Eliška Lexová , Prof. Petr Weiss
Published: July 2023

Objectives

The associations between pornography consumption and sexuality are still debated in recent research. Should we consider pornography harmful or rather beneficial for relationships? The research aimed to point out the associations between the consumption of pornography in relationships and the frequency of sexual activities, sexual desire, and sexual satisfaction.

Methods

Having used an online questionnaire, we compared individuals from relationships in which pornography is consumed together, separately, by only one of the partners, or not at all. The sample for the current study included 1 742 participants. Overall, the average relationship length in the sample was 81.2 months. For data analysis, ANOVA and ANCOVA were used, followed by the Kruskal-Wallis test and the Chi-square test of independence. Based on previous research, we included various factors and covariates in the elementary association between patterns of pornography consumption and partner sexual activity that could interfere with the results of the main analysis. This includes, for example, age, gender, marital status, education, religion, etc.

Results

One-way ANOVA indicated a significant main effect of the way pornography is consumed in relationships on sexual desire, F (3,1738) = 11.57, p = <.001, η2 =.020, and on sexual satisfaction, F (3,1738) = 65.18, p <.001, η2 =.101. Individuals who consume pornography together with partner and non-consumers had the highest frequency of sexual activity per month and were the most sexually satisfied compared to relationships where pornography is consumed separately or by only one of the partners. Also, partners consuming pornography together still had the highest sexual desire.

Conclusions

Overall, these findings suggest that it is preferable to consume pornography in a relationship together, or rather not at all. The significance of the results is discussed also in relation of various intervening variables entering into the relationship between patterns of pornography use and partner sexual activity.

Conflicts of Interest

The authors have no competing interests to declare that are relevant to the content of this presentation.
(144) STEP-BY-STEP PROCEDURE: IMPLANTATION OF A MALLEABLE PENILE PROSTHESIS
Authors: Priv-Doz. Daniar K Osmonov , Ahmed M Ragheb , Dr. Jan Novák
Published: July 2023

Objectives

In this video, we present an implantation of a malleable penile prosthesis in a 73-year old male who previously underwent radical prostatectomy for prostate cancer with subsequent radiotherapy. Additionally, he underwent implantation of an inflatable penile prosthesis AMS 700 and an arteficial urinary sphincter AMS 800. Since recently his inflatable penile prosthesis is defective and the patient prefers implantation of a malleable penile prosthesis. The aim of the video is to stress out the main differences between implantantion of an inflatable and a malleable penile prosthesis.

Methods

0

Results

0

Conclusions

0

Conflicts of Interest

Daniar K. Osmonov – Coloplast Porges.
(35) THE KIEL KNOTS TECHNIQUE FOR THE TREATMENT OF CONGENITAL AND ACQUIRED PENILE CURVATURE
Authors: Osmonov Prof Daniar , Ahmed Ragheb
Published: July 2023

Objectives

We propose a surgical technique for the correction of both congenital and acquired penile curvatures. Our technique is based on modifying and combining the 16-dot and the Essed-Schroeder plication techniques by burying the knots in shallow troughs of the incised tunica albuginea. We entitle this modification as the “Kiel Knots”. In this video, we demonstrate step-by-step the Kiel Knots technique for the correction of a case of dorsal acquired curvature with good erectile function via the subcoronal approach.

Methods

A circumcising incision is made and the penis is degloved. Buck’s fascia is then incised exposing the tunica albuginea opposite to the curvature. Eight dots 5mm apart are marked bilaterally on the tunica albuginea with the point of maximum curvature in the center and a 5 mm superficial transverse incision is made along each mark without cutting into the corpus cavernosum. Instead of plicating with one suture for 4 dots, our modification entails utilizing a separate suture for every two dots with the knot being buried in the shallow trough we created by the scalpel.

Results

Our average operative time is an hour. An average loss of penile length of 0.5-1cm has been reported in 30% of our patients. All our patients preserved their erectile function. 90% of our patients remained without recurrence of curvature after 2 years of surgery. None of our patients reported problems with their suture knots.

Conclusions

Our technique achieves penile straightening with minimal loss of length and no erectile dysfunction. We believe that the “Kiel Knots” technique combines the best of Lue’s 16 dot technique together with the Essed-Schroeder plication technique while avoiding the downsides of both approaches.

Conflicts of Interest

The authors have no conflict of interest.
(189) INVESTIGATING THE RISK FACTORS OF PENILE ARTERIAL INSUFFICIENCY AND VENO-OCCLUSIVE DYSFUNCTION IN PATIENTS WITH ERECTILE DYSFUNCTION
Authors: Dr. Mohamad Habous , Dr. Ahmed Khattak , Gordon Muir
Published: July 2023

Objectives

penile arterial insufficiency (PAI) is a known cause of erectile dysfunction (ED). It was reported that a more generalized peripheral atherosclerotic process is associated with a severer PAI, and this in turn was correlated well with decreased blood supply in more important arteries like the coronary and carotid arteries. We investigated the risk factors for PAI.

Methods

Patients who attended our urology clinic complaining of ED for more than 6 months, were prospectively enrolled in this study in one year period. Patient consent was taken and ethical committee approval. Complete medical history and thorough general and local examination including body mass index (BMI), Peyronie’s disease (PD) and penile size measurements (length and girth) were done for all of them. Laboratory tests included testosterone, lipid profile, and glycated haemoglobin (HbA1c). Penile duplex ultrasound study (PDU) was done for all patients after intra-cavernosal injection (ICI) with Alprostadil. peak systolic velocity (PSV) and end diastolic velocity (EDV) were measured after 15 minutes.

Results

Patients who attended our clinic complaining of ED for more than 6 months, were prospectively enrolled in this study in one year period. Patient consent was taken and ethical committee approval. Complete medical history and thorough general and local examination including body mass index (BMI), Peyronie’s disease (PD) and penile size measurements (length and girth) were done for all of them. Laboratory tests included testosterone, lipid profile, and glycated haemoglobin (HbA1c). Penile duplex ultrasound study (PDU) was done for all patients after intra-cavernosal injection (ICI) with Alprostadil. peak systolic velocity (PSV) and end diastolic velocity (EDV) were measured after 15 minutes.

Conclusions

Aging, tobacco consumption, DM and hypertension seem to have a negative impact on penile hemodynamics, which was statistically significant. In our patients, there was no statistically significant effect on penile hemodynamics in patients with increased BMI, low testosterone, PD or according to penile size

Conflicts of Interest

None
(36) DRAINED VERSUS NON-DRAINED INFLATABLE PENILE PROSTHESIS IMPLANTATION: A MULTICENTER PROSPECTIVE NONRANDOMIZED PILOT STUDY
Authors: Prof. Daniar Osmonov , Ahmed Ragheb , Prof. Tim Petry , Dr. Ahmed Eraky , Prof. Carlo Bettocchi , Prof. Glenn Lamers , Prof. Koenraad Van Renterghem , Prof. Marina Tropmann-Frick , Prof. Klaus-Peter Jünemann , Prof. Giulio Garaffa , Prof. Hartmut Porst , Ahmed Mohamed , Prof. Steven Wilson
Published: July 2023

Objectives

Our goal was to understand the risks and benefits of post-inflatable penile prosthesis (IPP) implanation drainage and optimal duration.

Methods

Patients underwent IPP implantation for the first time by four European high volume surgeons. They were divided into 3 groups based on the presence and duration of drainage. Group 1 (n=114) had no drain placed, Group 2 had a drain placed for 24 hours (n=114) and Group 3 had a drain placed for 72 hours (n=117). The presence or absence of postoperative (PO) scrotal hematoma and prosthesis infection were evaluated and compared between the groups via scrotal ultrasound (US) examination carried out 24 hours then 3 and 10 days PO. All patients were followed up postoperatively for a minimum of 80 days.

Results

The exact distribution of hematoma prevalence was greatest on the 3rd PO day with the highest rate in Group 1: (n=13, 11.4%) followed by Group 2: (n=7, 6.1%) and the least in Group 3: (n=1, 0.9%). The patients from Group 3 demonstrated a statistically significant lower incidence of hematoma on the 10th PO day: (n=1, 0.9%) compared to Group 2: (n= 11, 9.6%) and Group 1: (n=8, 7%, p=0.013). However, on the 3rd PO day, there was a statistically significant lower incidence of hematoma in Groups 3 and 2: (1% and 7%, respectively) versus Group 1: (11.4%, p=0.004). Hematoma rates followed the same group order after the first day of surgery: 8.8% (n=10), 5.3% (n=6), and 1.7% (n=2), respectively. (p=0.054). Five patients (4.4%) in Group 1 and four patients (3.5%) in Group 2 developed an IPP associated infection, opposed to only a single patient (0.85%) in Group 3.

Conclusions

Prolonged scrotal drainage for 72 hours after virgin IPP implantation significantly reduces hematoma and infection rates. It is likely that hematoma formation is per se a predisposing factor for IPP infection.

Conflicts of Interest

The authors of no conflict of interest.
(38) THE AM-EDITS: A NEW TOOL FOR EVALUATING THE ARABIC SPEAKING PATIENT AND PARTNER SATISFACTION FOLLOWING PENILE PROSTHESIS IMPLANTATION
Authors: Ahmed Ragheb , Prof. Daniar Osmonov , Dr. Mahmoud Abdallah , Prof. Akram Elmarakby , Prof. Amr Massoud , Dr. Mohammed Emadelidin , Prof. Ahmed Abdelbary
Published: July 2023

Objectives

Our aim was to introduce a validated and culture-adapted Arabic version of the Modified Erectile Dysfunction Inventory of Treatment Satisfaction (M-EDITS) to be coined as the Arabic M-EDITS (AM-EDITS). We utilized it to investigate Arab patient and partner satisfaction after malleable penile prosthesis implantation (MPPI).

Methods

This was a prospective study of 120 patients undergoing MPPI by a single surgeon. We developed a validated Arabic version of the M-EDITS and coined it as the AM-EDITS. Three telephone encounters were conducted for each couple at 1 month, 3 months, and 6 months postoperative (PO). The first encounter covered general patient perioperative experience, from preoperative counseling till early after surgery. The second and third encounters focused on patient and partner satisfaction regarding implant utilization.

Results

Mean ages for the men and their spouses were 54.7±8.4 and 32.9±4.6 years, respectively. Over 82% of the patients showed a decreased level of anxiety after preoperative counseling. 96% of the patients reported a positive experience regarding their early PO days with above half exceeding their expectations. After 3 months, 82.5% of the men were satisfied, describing their erections to be 80% natural. Of the 92.5% satisfied wives at 3 months, 78.5% were highly satisfied. Feeling sexually desirable by their husbands was reported in 93.4%. Opposed to the significant rise in men’s overall satisfaction and AM-EDITS index by 11.6% and 5.2 ± 0.8% (P <0.001), respectively after 6 months PO, partners demonstrated a 12.4% and 5.9 ± 0.8 decline (P <0.001), respectively, compared to the 3 months PO.

Conclusions

The AM-EDITS may expand the global application of the M-EDITS. MPPI represents a good quality of life treatment option for low-income countries. Time has a positive effect on the Arab men’s PO satisfaction, opposed to their partners’. These findings should be considered during perioperative counseling of both parties to ensure sustainable satisfaction.

Conflicts of Interest

The authors have no conflict of interest.
(314) MED3000, A CLINICALLY PROVEN, FAST-ACTING TOPICAL PRODUCT FOR ERECTILE DYSFUNCTION WITH THE PROSPECT OF BEING THE FIRST GLOBALLY AVAILABLE OTC TREATMENT FOR ED
Authors: Dr. David Ralph , Tim Holland , Ken James ,   On behalf of Futura Medical Developments Ltd
Published: July 2023

Objectives

To assess the effectiveness, onset of action and safety of MED3000 gel over a 24-week treatment period in male patients clinically diagnosed with ED.

Methods

100 male patients clinically diagnosed with ED were randomised into two treatment groups, 50 to MED3000 and 50 to Tadalafil (5mg) in 11 Investigational sites in USA, Poland Georgia and Bulgaria.

Results

Both Co-Primary end points were achieved (P<0.001) (1) Mean IIEF-EF change from baseline at 24 weeks (2) Minimal clinically important difference (MCID) exceeded at 24 weeks). 61% of MED3000 users exceeded the MCID at 24 weeks The mean IIEF score at weeks 4, 8, 12, 16, 20, 24 was 4.59, 5.20, 5.12, 5.83, 5.57 5.73 Secondary Endpoint 10 minute onset of action FDA agreed standard for achieving a 10 minute onset of action was achieved. A key differentiator from PDEi's Effective in Mild, Moderate and Severe ED MED3000 also delivered a clinically meaningful outcome over 24 weeks in accordance with the Rosen 2, 5 and 7 criteria (Rosen et al 2011)1 in mild, moderate and severe ED subjects Adverse Events (<2 incidences) are detailed in figure 1.

Reference

1 – Rosen RC et al “Minimal clinically important differences in the erectile function domain in the International Index of Erectile Function Scale Eur Urol 2011;60(5):1010-6

Conclusions

MED3000 has been shown to deliver a clinically meaningful response and is fast-acting. It was also shown to be clinically effective in mild, moderate and severe ED. Results were generally consistent with a previously conducted clinical study used for European approval MED3000 was shown to have minimal adverse events. Its “drug-free” formula provides a further margin of safety with no propensity for adverse drug interactions. This profile makes it suitable for OTC use.

FDA filing for marketing authorisation as a De Novo medical device occured in October 2022.

Conflicts of Interest

Professor David Ralph is a consultant to FMD Tim Holland and Ken James are employees of FMD The study was funded by FMD (Not for promotional purposes in the US).
(311) HYALURONIC ACID INJECTION IN LIFELONG PREMATURE EJACULATION
Authors: Prof. Nicola Mondaini , Dr. Gianluca Scarpelli , Dr. Fabio Crocerossa , Dr. Pela Bisatti , Dr. Andrea Abramo , Prof. Francesco Cantiello , Prof. Rocco Damiano , Prof. Antonio Aversa
Published: July 2023

Objectives

The therapeutic management ofPremature long-life ejaculation (PE) ranges from behavioral therapy to pharmacological treatments. Hyaluronic acid (HA) injection into the glans penis is a non-surgical procedure, intended to reduce glans hypersensitivity, improving the Intravaginal Ejaculation Latency Time (IELT). In this pilot study, we tested the effectiveness of a new technique based on a single HA injection into the frenulum of the glans, to improve IELT in a sample of patients affected by PE.

Methods

IELT was evaluated for each couple. We evaluated also International Index Ercectile Function (IIEF) and Premature Ejaculation Diagnostic Tool (PELT). All patients signed the informed consent. 8 mg of hyaluronic acid sodium salt (IBSA), without local anesthesia, were injected with a 27 G needle at the level of the frenulum of prepuce, corresponding to a triangle that we have named MONAVER (abbreviation form inventors, Mondaini-Aversa). After Injection a light compressive dressing was applied to the penis for 24h. All patients completed the VAS SCALE for pain.

Results

We observed a significant increase of the IELT, in 31 males (25-50 years) enroled in the study, after 1 (median 73.3, IQR 66.2-79.9 seconds) and 2 months (66.2, 63.1-73.9) that gradually decreased at 3-months, remaining still significantly higher than at baseline (34.8, 30.9-37.4). PELT and IIEF questionnaires significantly improved compared to baseline in the first two months of follow-up (p < 0.001).

Conclusions

The preliminary results emerging from this pilot study, highlight the effectiveness of this new HA injection approach, although a larger sample and longer follow-up time are needed to standardize the procedure.

Conflicts of Interest

None
(207) ANDROLOGICAL EFFECTS OF SARS-COV-2 INFECTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Dr. Walter Vena , Prof. Giovanni Corona , Dr. Alessandro Pizzocaro , Prof. Francesco Pallotti , Prof. Donatella Paoli , Dr. Giulia Rastrelli , Prof. Elisabetta Baldi , Prof. Nicola Cilloni , Dr. Alessandro Brunetti , Prof. Mauro Gacci , Prof. Federico Semeraro , Prof. Andrea Salonia , Prof. Suks Minhas , Prof. Rosario Pivonello , Dr. Alessandra Sforza , Prof. Linda Vignozzi , Prof. Andrea Isidori , Prof. Andrea Lenzi , Prof. Mario Maggi , Prof. Francesco Lombardo
Published: July 2023

Objectives

The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarifed. Our aim is to evaluate the available evidence regarding possible andrological consequences of COVID-19 either on seminal or hormonal parameters. The safety of the COVID-19 vaccines in terms of sperm quality was also investigated.

Methods

All prospective and retrospective observational studies reporting information on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) mRNA semen and male genitalia tract detection (n=19), as well as those reporting data on semen analysis (n=5) and hormonal parameters (n=11) in infected/recovered patients without any arbitrary restriction were included.

Results

Out of 204 retrieved articles, 35 were considered, including 2092 patients and 1138 controls with a mean age of 44.1±12.6 years, and mean follow-up 24.3±18.9 days. SARS-CoV-2 mRNA can be localized in male genitalia tracts during the acute phase of the disease. COVID-19 can result in short-term impaired sperm and T production. Available data cannot clarify long-term andrological efects. Low T observed in the acute phase of the disease is associated with an increased risk of being admitted to the Intensive Care Unit or death. The two available studies showed that the use of mRNA COVID-19 vaccines does not affect sperm quality.

Conclusions

The results of our analysis clearly suggest that each patient recovering from COVID-19 should be monitored to rule out sperm and T abnormalities. The specifc contribution of reduced T levels during the acute phase of the infection needs to be better clarifed.

Conflicts of Interest

The authors declare that they have no confict of interest.
(26) SEXUALLY TRANSMITTED DESEASES AND ADHD: A SYSTEMATIC LITERATURE REVIEW
Authors: Lorenzo Soldati , Roland Hasler , Pauline Schockaert , Marie-Pierre Deiber , John Köhl , Mylène Bolmont , Prof. Nader Perroud
Published: July 2023

Objectives

Subjects with attention-deficit/hyperactivity disorder (ADHD) suffer from inattention, hyperactivity and impulsivity. Clinicians often assume that the specific difficulties of ADHD are bound to affect sexual behaviours, and favour risky sexual behaviors (RSBs), thereby increasing the frequency of sexually transmitted diseases (STDs). This review is intended to provide an up to date synthesis of the literature surrounding STDs in patients with ADHD.

Methods

A systematic review of the literature was performed using Medline, PsychInfo and Embase databases, with STDs as the main outcome measure.

Results

8 articles were included in the systematic review.

Three studies showed significantly higher frequencies of STDs in ADHD populations and three did not show any significant difference with control. Two studies showed a signifiantly lower age at first STD contraction. Two studies showed that use of ADHD medication was related to a lower risk of subsequent STD.

Conclusions

This is the first systematic review of STDs in individuals with ADHD, suggesting that subjects with ADHD report more STDs than the general population.

Some authors hypothesized that these results could be explained by impulsivity, hyperactivity and inattention of ADHD, but also emphasized the role of psychiatric comorbidities, especially substance use disorders.

The results of this review lead us to recommend that psychiatrists treating ADHD make their patients aware of the risk of STDs and that better compliance with medication is a protective factor for STDs.

Results are limited by the small number of existing studies as well as the heterogeneity of the outcome measures. Further studies are warranted to better evaluate the risk of contracting a STD in subjects with ADHD.

Conflicts of Interest

The authors have no conflict of interest to declare.
(195) IS THE STRETCH FLACCID PENILE LENGTH (SFPL) COMPARABLE WITH ERECT PENILE LENGTH (EPL)?
Authors: Dr. Manuel Alonso-Isa , Dr. Borja García-Gómez , Dr. Guillermo Celada-Luis , Dr. Alessandro Fiorillo , Dr. Daniel Tueti-Silva , Dr. Esther García-Rojo , Eduard García-Cruz , Javier Romero-Otero
Published: July 2023

Objectives

SFPL is the length that a non-erect penis can be comfortably extended to. It has been suggested that SFPL is an excellent surrogate for erect penile length EPL. We aimed to evaluate if the SFPL accurately reflects EPL.

Methods

We retrospectively review a total of 225 patients from February 2021 to October 2022 who underwent penile ultrasonography with prostaglandin injection (10 mcg). Demographic, vascular and other relevant variables were recorded for analysis. A history of Peyronie disease or penile surgery (excluding postectomy and frenuloplasty) were exclusion criteria. After injecting prostaglandin, measures of the penis were taken (in cm) and only grade 3 of Erection Hardness Score (EHS 3) and 4 (EHS 4) were included.

Three different urologists did all the measurements using a caliper, which was placed along the dorsal side of the penis, extending from the pubo-penile skin junction to the tip of the glans where the pre-pubic fat pad was pushed to the bone.

Results

Mean age 48 (range 17-98). Mean penis size (flaccid) 10.07cm (range 4-17). Mean SFPL 15.32 (range 10.4-19.7). Mean EPL 14.37 (range 9.0-19.5). Mean SFPL (EHS 3) 15.30 (range 10.4-19.6). Mean SFPL (EHS 4) 15.37 (range 11.4-19.7). Mean EPL (EHS 3) 14.05 (range 9.0-19.5). Mean EPL (EHS 4) 14.76 (range 11.0-19.0).

Pearson’s correlation coefficient between SFPL and EPL (EHS 3 and 4): r = 0.646

Pearson’s correlation coefficient between SFPL and EPL (EHS 3): r = 0.530

Pearson’s correlation coefficient between SFPL and EPL (EHS 4): r = 0.574

Conclusions

A correlation between SFPL and erect EPL has been found. We can consider SFPL a fairly approximate measure in most cases of EPL.

Conflicts of Interest

Authors have no potential conflict of interest to report.
(279) THE ROLE OF TESTOSTERONE TREATMENT IN PATIENTS WITH METABOLIC SYNDROME: RESULTS FROM A META-ANALYSIS STUDY
Authors: Dr. Walter Vena , Dr. Nicola Bianchi , Dr. Francesca Frizza , Dr. Francesca Briganti , Prof. Giulia Rastrelli , Prof. Linda Vignozzi , Prof. Arcangelo Barbonetti , Dr. Alessandro Pizzocaro , Dr. Alessandro Brunetti , Prof. Edoardo Mannucci , Dr. Alessandra Sforza , Prof. Mario Maggi , Dr. Giovanni Corona
Published: July 2023

Objectives

Metabolic syndrome (MetS) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone [T] replacement therapy [TRT] on glycometabolic profile and body composition, in patients with metabolic syndrome [MetS], is still conflicting and argue of large scientific debate. The aim of the present study is to meta-analyze the role of TRT in MetS considering all placebo and non-placebo-controlled randomized clinical trials [RCTs].

Methods

An extensive Medline search was performed including the following words “testosterone”, “metabolic syndrome” and “males”. No search software was used, but we hand-searched bibliographies of retrieved papers for additional references.

Results

Overall, 7 studies were available including 576 patients with a mean follow-up of 48.9 weeks. These trials differ in basal TT levels and type of T preparation used. In addition, only 6 were placebo controlled. TRT resulted to significantly improve waist circumferece, fasting glycemia, A1c serum levels, HOMA-Indes and serum tryglycerides (p < 0.001) when all studies were considered, however this difference was not significant when only placebo-controlled studies were considered, except for waist circumference (p= 0.05). When only placebo/controlled RCT were considered, TRT resulted to significantly improve body fat mass (p= 0.04).

Conclusions

TRT was able to significantly decrease fasting glycaemia, glycosylated hemoglobin, HOMA-IR index, triglyceride levels, fat mass and waist circumference. In contrast, we did not observe any significant effect on total or HDL cholesterol, blood pressure and BMI. When considering only placebo-controlled studies, only differences of HbA1c, HOMA-IR index, triglyceride levels, fat mass and waist circumference retained statistical significance, but not fasting glycaemia, although a trend was apparent.

Conflicts of Interest

No conflict of interest to declare.
(107) CAN AGEISM RELATED TO ELDERLY PEOPLE AND DYSFUNCTIONAL BELIEFS ABOUT SEXUALITY OF ELDERLY PEOPLE BE ASSOCIATED WITH SEXUAL ACTIVITY AND SEXUAL LIFE? A COMPARISON BETWEEN HETEROSEXUAL AND HOMOSEXUAL MEN AND WOMEN
Authors: Dr. Erika Limoncin , Dr. Luca Flesia , Dr. Elena Colonnello , Dr. Daniele Mollaioli , Dr. Andrea Sansone , Prof. Giacomo Ciocca , Prof. Emmanuele Angelo Jannini
Published: July 2023

Objectives

No information exists about the impact of ageism and dysfunctional beliefs on quality of sexual life of elderly people, considering several sexual orientations. Aim of this study was to evaluate: (1) the presence of “ageism” in elderly heterosexual and homosexual persons (2) the impact of ageism on sexual activity/sexual satisfaction of elderly heterosexual and homosexual persons (3) the impact of dysfunctional beliefs about elderly people on sexual activity/sexual satisfaction.

Methods

Elderly people were evaluated cross-sectionally through an online survey managed using GoogleForms. To enrol elderly heterosexual and homosexual people, the link was then disseminated to LGB communities and social media. Evaluation of demographics, of physical and psycho-social wellbeing, of the ageism and of dysfunctional beliefs was made with an explorative questionnaire.

Results

The results showed no statistically significant difference between homosexuals and heterosexuals in terms of the presence of ageism related to old age (p=0,47). On the contrary, homosexuals perceive significantly less the social representation of sexuality of elderly people in respect to heterosexual ones (p=0,0007). Dysfunctional beliefs about sexuality of elderly people are significantly more present among heterosexual people (p=0,0001). In terms of sexual behaviour, elderly homosexual people declared significantly higher frequency of sexual activities (p<0,05), compared to that referred by heterosexual persons.

Conclusions

In line with these findings, it is possible to suppose that ageism related to sexuality, expressed as the absence of social representation of sexuality in elderly people, is more present in homosexuals, while dysfunctional beliefs about sexuality could impact more on sexuality of heterosexual people.

Conflicts of Interest

All the authors declared no conflict of interests. Prof. Jannini Emmanuele declared to have or have been speaker/paid consultant for: Bayer, Ibsa, Lundbeck, Menarini, Otsuka, Pfzer, Shionogi, and Viatris.
(234) THE PARAPHILE PROJECT: AN OVERVIEW OF EDUCATIONAL ACTIVITIES AND THEIR OUTCOMES IN THE TARGET GROUP OF POLICE OFFICERS
Authors: Leona Plášilová , Kateřina Potyszová , Marek Navrátil , Kateřina Klapilová
Published: July 2023

Objectives

The Paraphile project is a pilot project that started in 2019 in the Czech Republic at the National Institute of Mental Health. It has established a system of early interventions for people in increased risk of sexual offending on-line and off-line, namely for individuals with paraphilic sexual preferences (and their close persons). The project offers free and anonymous long-term psychotherapy led by trained professionals (psychologists, psychiatrists, sexologists). The project also disseminates its know-how among the general and professional public. Within the professional community, it targets police officers, social workers and health professionals who attend four-hour training course. Workshop topics include an introduction to paraphilia theory, an introduction to the system of care, the differences between deviance and delinquency, risk and protective factors for paraphilias, recidivism, and sexuality in cyberspace. Between 2021 and 2022, 75 police officers were trained by the Parafilik project and the effectiveness of this course for this target group was evaluated.

Methods

This paper will present preliminary data on the effectiveness of the project's training course for the target group of police officers, including measurements of specific variables before and after the training course. The variables include: professional competence to intervene toward a client with paraphilia, stigma, and emotional compliance. The evaluation also includes a qualitative summary of outcomes.

Results

The results are currently being analyzed and will be presented at the conference.

Conclusions

The results will contribute to the understanding of the training needs of police officers on the topic of paraphilias, including an evaluation of the training courses conducted and their effectiveness. This knowledge can be further used in future planning of educational activities on paraphilias and other sexological topics for the target group of police officers.

Conflicts of Interest

The authors declare that there is no conflict of interest.
(261) IMPACT OF A PROGRAM OF INTRODUCTION TO CLINICAL SEXOLOGY IN THE FIRST CYCLE OF MEDICAL STUDIES ON THE KNOWLEDGE OF STUDENTS
Authors: Ons Kaabia , Rim Bouchahda , Raouf Ben Abdesslem , Ryadh Ncibi , Khouloud Ikridih , Anouar Chaieb
Published: July 2023

Objectives

Sexual health is a pillar of young adult health. For medical students, one of whose training objectives is to educate the population about sexual health, it is necessary to check their basic knowledge, correct it and deepen it through an academic program. This work proposes to evaluate the impact of an initiation program in clinical sexology on the knowledge of learners in matters of sexuality.

Methods

This is a quasi-experimental study conducted on a random sample of students from our Faculty of Medicine who have followed the one-semester program of introductory training in clinical sexology in the second year of the first cycle of medical studies via a questionnaire validated by the line of professional development of the same Faculty.

Results

The intervention reached 245 students, 61 of whom completed the questionnaires concerning knowledge before and after the intervention with a follow-up of 2 years; i.e. a participation rate of 24.89%. Following the intervention, learners better discern the different fields of sexuality (78.7 vs 98.4%; p = 0.002), the notions of sexual pleasure and orgasm (78.7 vs 93.3%; p = 0.004). Similarly, they know better the means of contraception (78.7 vs 96.7%; p = 0.000), the normal course of pregnancy and childbirth (78.7 vs 93.3%; p = 0.004) as well as the sources of information to personal questions about their own sexuality (54.1 vs 72.1%; p = 0.019). Some false beliefs persist despite the intervention, such as the fact that masturbation is a pathological act (32.8 vs 34.4%; p = 0.791).

Conclusions

An introduction to clinical sexology in the curriculum of the 1st cycle of medical studies is useful for the training of a good doctor but cannot compensate for the shortcomings of a comprehensive sex education program.

Conflicts of Interest

Nothing to declare.
(205) SEXUAL EXPERIENCES OF TRANSGENDER PEOPLE IN POLAND
Authors: Katarzyna Zborowska , Daria Jorg , Bożena Chrapkiewicz , Prof. Violetta Skrzypulec-Plinta
Published: July 2023

Objectives

Transgender people may face serious challenges with their sexual experiences such as sexual behavior (ie the type and frequency of sexual activity) and sexual experience (eg their sexual pleasure) at various stages of the diagnosis and treatment process. The aim of the study was to assess sexual behavior, to assess the quality of sexual life at various stages of the process of diagnosis and treatment of transgender people.

Methods

104 transgender people who are sexually active were qualified for the study. The study was conducted in two medical centers. The research tool used in the study was the original questionnaire and the Life Satisfaction Scale (SWLS), the Sexual Satisfaction Questionnaire (KSS).

Results

The author's study also showed that both transgender women and transgender men after SRS achieve statistically higher results on the KSS scale compared to people before surgical gender reassignment. Moreover, it was found that trans people who accept their genitals have statistically higher scores of sexual satisfaction. There was no correlation between SRS and the stage of the diagnosis and treatment process and the act of masturbation. Additionally, it was indicated that transsexual people who experienced homosexual intercourse before legal gender reassignment had a higher sexual satisfaction score.

Conclusions

Transgender women are characterized by a higher sense of life satisfaction than transgender men at every stage of the diagnosis and treatment process. Transgender men are characterized by a higher assessment of sexual satisfaction during hormone treatment after legal gender correction in relation to transgender women. Surgical sex reassignment operations determine the assessment of sexual satisfaction among transgender people.

Conflicts of Interest

No Conflicts of Interest.
(329) HOW MANY TRANSGENDER PEOPLE ARE THERE IN ITALY? A POPULATION-BASED STUDY (THE SPOT STUDY)
Authors: Dr. Jiska Ristori , Dr. Marina Pierdominici , Dr. Matteo Marconi , Dr. Luisa Brogonzoli , Prof. Giovanni Castellini , Dr. Francesco Cipriani , Dr. Carlotta Cocchetti , Dr. Alessia Romani , Dr. Francesca Mazzoli , Prof. Mario Maggi , Dr. Alessandra Fisher
Published: July 2023

Objectives

The proportion of transgender population is growing. In Italy, the only available study dates back to 2011 and focuses on adult transgender population who underwent gender-affirming surgical treatment, thus underestimating transgender population size. Studies on the general population represent an urgent health issue.

Methods

A population-based study using a self-administered on-line questionnaire filled out anonymously was carried out. The survey included assessments of socio-demographic characteristics. Gender incongruence (GI) was evaluated by using the 2-item approach assessing gender assigned at birth and gender identity (male, female, both, neither, other). For people who identified as transgender the survey also included questions about the age of first awareness of one’s gender identity and the wish and/or history of gender affirming path.

Results

A total of 20.490 questionnaires were obtained online. Medium age of responders was 35.1±11.5 years old. The 9.9% of assigned male at birth (AMAB) and the 7.8% of assigned female at birth (AFAB) reported a transgender identity: among AMAB people, the 43.3% reported a full female gender identification, the 31% identified as both man and woman, 9.2% neither, and 16.4% other. Among AFAB people, the 39.3% reported a full male gender identification, the 26.4% identified as both man and woman, 19.4% neither, and 14.9% other. AMAB and AFAB trans people reported early awareness of GI. Among AMAB trans people, 46.2% does not wish legal name change, 35.6% hormonal treatment, and 41.7% surgical procedures. Among AFAB trans people, 40% does not wish legal name change, 39.1% hormonal treatment, and 34.5% surgical procedures.

Conclusions

Our results show higher percentages of transgender people in the general population compared to previously published studies. The number of non-binary trans population was consistent with previous data. Overall, these results could be considered as a first step towards a more effective Italian health planning in order to properly address transgender health care needs.

Conflicts of Interest

The authors declare no conflict of interest.
Liberius on Athanasius at Arles, Milan, and in Constantius’ Court
Authors: McCashen Grayden
Published: July 2023

Liberius is often viewed as Athanasius’ ally in the mid-350s, but his own writing, contemporary testimony, and the pagan historian Ammianus Marcellinus suggest otherwise. Rather than defending Athanasius at the councils of Arles and Milan and in Constantius II’s court, Liberius attempted to establish acceptable conditions for peace in the Church by trading Athanasius’ excommunication, which he saw as justified by Athanasius’ refusal to comply with traditional ecclesial-judicial procedures, for doctrinal concessions from certain Eastern bishops whom Liberius suspected of sympathizing with heretical doctrine.
Monitoring SDG localisation: an evidence-based approach to standardised monitoring frameworks
Authors: Ciambra Andrea , Siragusa Alice , Proietti Paola , Stamos Iraklis
Published: July 2023

This article studies closeness between indicators that local governments use to monitor Sustainable Development Goal (SDG) implementation in their Voluntary Local Reviews (VLRs) and those included in the standardised set of indicators of the European Handbook for SDG Voluntary Local Reviews. To do so, it develops an index of ‘indicator proximity’ through a qualitative semantic comparison between 2354 indicators used in a sample of 29 VLRs and the 72 indicators included in the Handbook’s standardised set. The index includes absolute and relative scores, taking into consideration size, comprehensiveness and diversity of the indicator sets included in the sample, as well as the methodological features of the Handbook’s set. The index allows to identify the VLRs with higher or lower proximity to the indicators in the standardised set and the SDGs that elicit a higher or lower degree of closeness between standard metrics and indicators selected or defined by local governments. The output shows that VLRs and the Handbook have an overall significant degree of proximity; that variables such as local government type or size or the size of VLR indicator sets do not provide additional explanation for proximity; and that SDGs that can be monitored with locally accessible and affordable data elicit higher indicator proximity.