bluuebunny/crossref_metadata_2025 huggingface dataset:
PREDICTION OF BIOLOGICAL ACTIVITIES OF A. SQUAMOSA BIOACTIVE COMPOUNDS BY-SILICO DESIGN
Authors: Katole Ravindra Madhukar , Sharma Mukesh Kumar , Joshi Chetan Kumar
Published: May 2022

Annona squamosa L. belongs to the Annonaceae family and is one of the basic dietary plants with edible fruits and is called "custard apple. The aim of our study was to carry out to PASS Predication investigate potential Prediction of Activity Spectra for phytoconstituents from Alpinia calcarata namely Acetogenins, Isoquinoline, Quercetin 3 Oglucoside, phenanthrene and Anoreticuin towards many deasease. Server based in silico pass prediction of the compounds was performed. Selected phytochemicals were also analyzed for ADME/T properties using the ADMET protocol. Among a wide range of predicting Acetogenins, Isoquinoline, Quercetin-3-O-glucoside, Phenanthrene and Annoreticuin are effective against fungal pathogens of CYP2H substrates and inhibitors of membrane permeability (0.66 less than Pa greater than 0.90) activity and this can be supported by ADMET properties of these compounds. So Acetogenins have good absorbability, especially in human intestinal absorption. Isoquinoline and norepinephrine are kinase inhibitors, while the high molecular weight compounds phenanthrene and norepinephrine have a low GI absorption distribution across the blood-brain barrier (BBB) and central nervous system. Also the results from ADME/T properties ensured the compounds safe for human.
EXPRESSION OF ALPHA-FETOPROTEIN IN THE EARTHWORM EUDRILUS EUGENIAE
Authors: Balakrishnan Subburathinam , Lathakumari Saranya , Kanniah Paulkumar , Sivasubramaniam Sudhakar
Published: May 2022

The earthworm Eudrilus eugeniae, commonly called as “African night-crawler” is a segmented animal which is divided into three major segments such as anterior, clitellar and posterior segments. The earthworm has enormous ability to regenerate the autotomized or lost body parts. The clitellar region plays a pivotal role in the regeneration of both anterior and posterior region of earthworm. In the present study, the Alpha-fetoprotein (AFP) sequence was retrieved from Eudrilus eugeniae transcriptome dataset and we found a contig in the size of 1873bp with 609 amino acids. The expression of the AFP was not detected in the body segment but the expression of the protein was confirmed only in clitellar and regenerative blastema by the immunoblot technique. Both in the clitellum and regenerative blastema, the AFP was located in the nucleus. The data suggest that AFP has a decisive role in the regeneration of earthworms.
VOLUMETRIC STUDY OF SACCHARIDE INTERACTIONS (D-ARABINOSE, D-XYLOSE, AND D-GALACTOSE) IN SODIUM SACCHARIN AT 298.15 K
Authors: Kharat Sanjeevan J. , Jondhale Valmik R.
Published: May 2022

Volumetric investigations are effective for attributing the interactions between saccharides and sodium saccharin in aqueous medium. The densities with the help of bicapillary pycnometer were measured for monosaccharide (D(-)- arabinose, D(+)galactose and D(+)-Xylose) (0.04 to 0.20) m (mol.kg-1) in water and aqueous sodium saccharin solution with molality, m = (0.05, 0.15 and 0.3) at 298.15 K. Experimental data were used to calculate the partial molar volume and apparent molar volume . The corresponding transfer volumes were calculated and showed a positive and increasing trend with concentration for saccharides from water to aqueous medium of sodium saccharin. With the help of McMillan-Mayer theory, the interaction coefficients ( ) and ( ) were calculated. In the presence of sodium saccharin, significant interactions between a hydrophilic group of saccharides and the sodium ion have been reported. Using apparent specific volume values, a sweet taste range was identified for saccharides in the presence of sodium saccharin.
EXPLORING THE ABIOTIC AND BIOTIC STRESS TOLERANCE POTENTIAL OF RHIZOBACTERA ISOLATED FROM CYAMOPSIS
Authors: Jain Ritika , Saraf Meenu
Published: May 2022

Agriculture plays a vital role for any economy primarily for developing and under developed economies. Increasing abiotic as well as biotic stresses adversely affects crop productivity across the world. Microorganisms inhabiting the Rhizospheric region of plant soil are known to play an important role in alleviating these stresses, thus enhancing crop productivity and yield. The present study was carried out to isolate the Rhizospheric bacteria from Cyamopsis showing potential to tolerate abiotic and biotic stresses. To carry out this, bacteria were isolated from Rhizospheric soil of Cyamopsis which were collected from different regions of Gujarat. These isolates were screened for tolerance to different abiotic stresses such as temperature, pH, salt and drought. Highly abiotic stress tolerant isolates were further tested for biotic stress against pathogenic bacteria and fungi. Among the 80 bacterial isolates, best grown 30 cultures were tested for different abiotic stress. Four cultures i.e. MN40, KM1, KM6 and AK17 showing high tolerance to abiotic stresses were further investigated for biotic stress tolerance. Selected cultures were tested for their antagonistic activity against pathogenic fungi viz., Macrophomina phaseolina, Fusarium oxysporium, Sclerotinum rolfissii and Trichoderma spp. Furthermore, antimicrobial activities of all 4 selected bacterial strains were tested against different test organisms viz., Gram negative bacteria (Salmonella typhi) and Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus). Amongst the 4 selected bacterial strains, KM6 shows highest antagonistic activity.
ROLE OF MANCOZEB IN PROTEIN METABOLISM DURING GERMINATION OF PADDY CULTIVARS
Authors: R. Anitha S. , K. Krishna , G. Savitha
Published: May 2022

Interaction of plants to abiotic stress is complex and involve various physiological and biochemical responses. A common response of plants to fungicidal stress is the accumulation of proteins and amino acids. Amino acids and other soluble nitrogenous compounds play an essential role in plant metabolism. Hence the present work was carried out to study the effect of different concentrations of mancozeb on protein metabolism during the germination of paddy cultivars. The seeds were soaked in different concentrations of mancozeb and control was maintained. Seed treatment with mancozeb suppressed the protein content but significantly increased the protease activity, free amino acids and proline content in relation to progressive concentrations of fungicide. Thus mancozeb act as modulator and endow plants with capacity to adapt to stressful condition by biological and physiological adjustment at cellular level.
A STUDY ON THE ADSORPTION OF Ni(II) IONS FROM WASTEWATER USING ACID ACTIVATED ANISOMELES MALABARICA LEAVES
Authors: Priya C. Geetha , Venkatraman B. R.
Published: May 2022

In the present investigation, the efficiency of activated carbon prepared from Anisomeles malabarica leaves (AMC) as an adsorbent for the removal of Ni (II) ion was investigated. Anisomeles malabarica leaves were treated with sulphuric acid before adsorption. The influence of various operating conditions such as adsorbent dosage, initial concentration of adsorbate, contact time, pH and temperature were explored in a Batch adsorption technique. The Langmuir, Freundlich and Tempkin isotherm models were used to compute the experimental outcomes. Freundlich Isotherm model were fitted well than that of other two isotherm models. The maximum adsorption capacity was obtained as qm =361.73 mg/g with the optimum conditions of adsorbent dosage 25mg, temperature 30˚C, initial adsorbate concentration 30mg/L, contact time 30min and pH 6.5.
Understanding Consumer Resistance to the Consumption of Environmentally-Friendly Agricultural Products: A Case of Bio-Concentrated Liquid Fertilizer Product
Authors: Wu Zhen , Takahashi Yoshifumi , Yabe Mitsuyasu
Published: May 2022

Methane fermentation digested sludge is a sustainable resource that is used as a liquid fertilizer. An innovative liquid fertilizer called Bio-Concentrated Liquid Fertilizer (Bio-CLF) was developed to solve the problems such as high transportation cost associated with current liquid fertilizer. As an innovation product, Bio-CLF inevitably creates remarkable resistance from consumers. Hence, we used the Innovation Resistance Theory (IRT) to determine the reasons for consumer resistance to Bio-CLF products. A total of 2,000 samples from three major cities, including Tokyo, were extracted via the Internet, and 703 samples were finally selected for analysis. Perceived risk, complexity, and attitude toward existing products were found to have a positive and direct impact on consumer resistance to Bio-CLF products, while motivation and purchase intention were found to have a negative and direct impact on consumer resistance to Bio-CLF products. Notably, Relative Advantage and Compatibility had a positive impact on motivation and indirectly influenced consumer resistance to Bio-CLF products, the results of which are inconsistent with IRT, as those characteristics could have a direct influence on resistance. Additionally, we opted to provide some advice that for market managers: (1) allocate a specialized corner for the Bio-CLF product and (2) place the Bio-CLF product alongside other green products. For producers: (1) disclosure of production information; (2) design of an attractive and clear label sheet; (3) proving the advantage of Bio-CLF and that the Bio-CLF product is a green product.
Host Plant Reaction to Rice Yellow Mottle Virus and Allelic Diversity of RYMV1 Gene in Rice Cultivars in Uganda
Authors: Akwero A. , Otim M. H. , Ochwo-Ssemakula M. , Odong T. L. , Lamo J.
Published: May 2022

Rice Yellow Mottle Virus (RYMV) disease is endemic to Africa where it affects rice production. Host plant resistance would form a cost effective and sustainable option for managing the disease. However, there is still lack of knowledge on the reaction of rice germplasm and the genetic basis of their resistance/susceptibility to RYMV coupled with lack of molecular markers to facilitate the development of RYMV resistant varieties. We screened 56 rice accessions drawn from breeding lines and varieties commercially cultivated in Uganda for their resistance/susceptibility to RYMV. We also sought to develop and validate allele specific markers for RYMV1 alleles. The rice accessions showed variation in their reaction to RYMV; 14, 12, 17 and 13 accessions were categorized as resistant, moderately resistant, moderately susceptible and susceptible respectively. Among the resistant accessions, five possessed a single SNP (G/A) corresponding to the rymv1-2 allele. The new accessions can be deployed as resistant cultivars and/or used to introgress rymv1-2 allele into susceptible adapted cultivars throughout Africa. We developed two functional allele specific markers, which co-segregated with the rymv1-2 resistance allele in an F2 population and clearly differentiated between the susceptible and resistant individuals in the F2 population. The functional allele specific marker developed in this study can be used in MAS programs for introgression of rymv1-2 resistance allele.
Agronomic Efficiency of Signum Inoculant in Pre-inoculation of Soybean at 35 and 20 Days Before Sowing in Treated Seeds
Authors: Machineski Gabriela S. , Scaramal Andrea S. , Matos Maria A. , Langame Jonatas F. , Gaiser Giovana G. , Machineski Oswaldo , Filho Arnaldo Colozzi
Published: May 2022

Pre-inoculating soybean seeds can make sowing faster and provide additional benefits to farmers. However, it needs to guarantee the nitrogen supply to maintain the viability and sustainability of the technique. In this study, we evaluated the agronomic efficiency of SIGNUM® inoculant in the pre-inoculation at 20 and 35 days before sowing chemically treated soybean seeds. Experiments were conducted in four field experiments located at Paraná, Brazil, with a history of soybean cultivation managed under no-tillage systems, with crop rotation according to regional edaphoclimatic conditions. Agronomic efficiency in fields were compared with standard inoculation with a registered product used by farmers. Chemical treatment of soybean seeds with Standak Top® or Maxin XL® + Cruiser® associated with pre-inoculation of the inoculant SIGNUM® for 25 and 30 days reduced the concentration of viable Bradyrhizobium cells recovered from seeds. However, no significant difference was observed regarding nodulation, biological nitrogen fixation, and yield between the soybean inoculated with standard inoculation on farm or pre-inoculation with SIGNUM® in most studied areas.
Engaging Online Language Learners: A Practical Guide (Book Review)
Authors:   llinois State University, Kaosayapandhu Munchuree
Published: May 2022

Engaging Online Language Learners: A Practical Guide is a short introduction to online language teaching and approaches to student engagement in online environments. The authors note in their introduction that they are writing in response to the rapid introduction of online learning due to the COVID-19 pandemic, which resulted in many courses and teachers moving online for the first time. Rather than focusing on the negative aspects of this sudden shift in teaching practice (e.g., Cheong et al., 2021), the authors chose to focus on the opportunities that online learning presents for language teaching and learning. The purpose of the book, therefore, is to discuss why and how student engagement in online language learning should be a priority and what the next steps are for teaching and learning online. The book targets language teachers, including those who are teaching online for the first time and experienced online teachers.
sendero espiritual hacia la creatividad
Authors: Sánchez-Núñez Pablo
Published: May 2022

La reseña del libro El camino del artista escrito por Julia Cameron relata cómo la creatividad puede aprenderse, desarrollarse e implementarse en las actividades y proyectos de nuestro día a día. A lo largo de 12 capítulos y más de 110 tareas, Cameron propone cómo redescubrir y potenciar nuestra creatividad y a crear con mayor libertad a través de la utilización consciente de una serie de herramientas.
Políticas de accountability em educação básica no Brasil: um estudo a partir da revisão integrativa da literatura
Authors: Pinto Austrogésio Rocha , Pereira Ana Paula Cunha , Pereira Carlos Alberto Sanches
Published: May 2022

O presente artigo estuda a accountability na educação básica no Brasil. O objetivo central deste estudo foi o de apresentar uma síntese das publicações sobre políticas educacionais de accountability no Brasil. Como recurso metodológico utilizou-se a revisão integrativa da literatura, nas plataformas CAPES e REDALYC, definindo como critério de inclusão as palavras-chaves: educação básica no Brasil e accountability. Como resultados, os dados mostraram algumas preocupações teóricas e conceituais sobre o termo e, também, mostraram que, no Brasil, o termo foi mais recorrente a partir de 2005, quando foi reformulado o Sistema de Avaliação da Educação Básica (SAEB), possibilitando o desenvolvimento de estudos censitários.
Comunicação intercultural: A escola pública italiana e os diálogos plurilinguísticos
Authors: Oliveira Guimarães Solange Padilha , Tavares Maria de Lourdes Gaspar
Published: May 2022

Este artigo tem por tema o diálogo intercultural na formação docente, em classes plurilinguísticas. Tem-se por pressupostos teóricos os conceitos de comunicação intercultural em Giaccardi (2005) e a dialogicidade, segundo Paulo Freire (1977, 1980, 1983, 2004). A amostra analisada é composta das observações realizadas na classe plurilinguística M1, da escola pública italiana, inserida no Projeto CPIA5, na cidade de Milão, Itália, durante o ano letivo de 2018/2019. Os resultados obtidos constataram a presença de um diálogo intercultural sem a predominância de uma cultura sobre as outras, presentes naquele contexto escolar.  Como perspectivas, propõe-se a necessidade de se aprofundar os estudos nesta área, a fim de que se possam verificar os possíveis elementos formadores do trabalho docente, em classes multiculturais e plurilinguísticas.
Competências socioemocionais no currículo escolar: algumas reflexões
Authors: Santos Sousa Araujo Glauce Barros , Oliveira Eniz Conceição
Published: May 2022

O presente artigo buscou apresentar os resultados da revisão sistemática das produções científicas brasileiras sobre as competências socioemocionais no currículo escolar. Foram analisados estudos no Catálogo de Teses e Dissertação da Capes, Periódicos Capes e Scielo, no período compreendido entre 2011 a 2021. Os trabalhos foram desenvolvidos de forma quantitativa e qualitativa, utilizando para a análise de dados a análise textual discursiva (ATD), a partir da qual surgiram duas categorias emergentes, oriundas das mais diversas percepções e impressões das leituras dos textos analisados: competências socioemocionais: contribuindo na formação e desenvolvimento dos estudantes e currículos socioemocionais; novas percepções na vida dos alunos. Os estudos revelaram que as competências socioemocionais contribuem para a melhor formação e desenvolvimento dos estudantes de forma integral, e quando as mesmas são trabalhadas no ambiente escolar, permitem um rompimento de currículos convencionais e tradicionalistas, possibilitando novas formas de aprendizagens, tornando os sujeitos críticos, autônomos, resilientes, criativos e dinâmicos.
Relationship between hip muscle strength and lower extremity injuries in soccer players: Systematic review
Authors: Yévenes Ulloa Alexandra , Altamirano Miranda Enzo , Pereira Parra Constanza , Barría Saldivia Franco , Gomis Gomis María José , Fritz Silva Nicole B. , Contreras Díaz Guido
Published: May 2022

The objective of this review was to analyse the relationship between hip strength and lower extremity injuries in soccer players. PubMed, Scopus and WOS databases were reviewed. The initial search yielded a total of 613 studies, of which 6 were selected. The studies evaluated the movements of hip adduction, abduction, flexion and extension, in different positions, through dynamometry, concluding that the decrease in hip strength is a risk factor for lower extremity injuries in youth and professional soccer players, which can be determined through isometric, concentric, and eccentric strength testing.
KORELASI PERSEPSI CITRA TUBUH TERHADAP STATUS GIZI ORANG DEWASA DI DESA PANCUR, MAYONG, JEPARA
Authors: Cyntia Ratna Sari  , Hanifah Maharani
Published: May 2022

Lockdown during the Covid-19 pandemic caused changes in the perception of hunger, satiety and increased eating behavior in people around the world. As many as 48% of people feel their weight has increased. The increase in the incidence of obesity is inevitable. Obesity is widely associated with poor body image. This study wanted to explore differences in BMI and body image perceptions between men and women and the correlation between body image perceptions and nutritional status. This research is an analytical observational using a cross sectional design. The study took a population of adults living in Pancur Village, Mayong, Jepara with purposive sampling technique. Correlation test using Spearman's rank and (r) to see the strength of the relationship between body image perception and BMI. While the independent t-test to see differences in perception and BMI in adult men and women. The results of the Independent t-test showed that there were differences in body image perceptions for men and women, there were differences in BMI for men and women (p<0.05), and the Spearman rank test had a positive correlation between body image perceptions and BMI Nutritional status. (p<0.0009). Adult men and women have different perceptions of body image and nutritional status. Adult women are more concerned about the perception of their body image for themselves and in the eyes of others than adult men. The better the perception of body image, the closer the nutritional status to normal.
GAMBARAN PENGETAHUAN MAHASISWA D3 KEPERAWATAN TENTANG KERACUNAN MAKANAN DI STIKes SANTA ELISABETH MEDAN TAHUN 2021
Authors: David Manuel Simanjuntak
Published: May 2022

Knowledge is a participant's understanding of a given topic to receive, retain, and use information, which is influenced by experience and skills, most of the knowledge a person has comes from both formal and informal education, personal experience and other people, the environment, and the mass media. . Food serves as a vehicle for many pathogenic agents that cause what is known as food-borne illness or food poisoning. Lack of knowledge, attitudes and practices to prevent food poisoning can lead to food poisoning. Mishandled food and poor personal hygiene can cause pathogens to grow and multiply in sufficient numbers and cause disease in humans. Food poisoning is caused by a bacterial, viral, or fungal infection. The main sources of food poisoning include natural sources such as poisonous plants, chemical or metal contamination, such as pesticides and herbicides and from micro-organisms such as bacteria and viruses. The purpose of this study was to describe the knowledge of D3 Nursing students about food poisoning. The method in this research is descriptive method. The sampling technique used is a total sampling of 88 respondents. The results of the research conducted at STIKes Santa Elisabeth Medan as follows, the knowledge of D3 Nursing students at STIKes Santa Elisabeth was mostly very good, obtained as many as 62 respondents (70.5%). Knowledge of D3 Nursing students about food poisoning is in the very good category because the higher a person's education and life experience, the faster they can understand a condition.
PENGARUH EDUKASI IBU PEDULI DM TERHADAP PENGETAHUAN DAN PERILAKU PENCEGAHAN DM
Authors: Maharani Hanifah , Dana Yoga Adhi , Sari Cyntia Ratna
Published: May 2022

This study aims to find out the influence of education of DM-concerned mothers on changes in knowledge and behavior of DM prevention. Quacy experimental study using the pre-test post-test design with control group. The study took the maternal population in Japanese villages, with purposive sampling techniques. Bivariate analysis tested differences in average results and changes in knowledge, as well as maternal behavior before and after intervention in one group tested with paired t-tests while between groups using independent ttest . The correlation test with Pearson and Rank spearman, while the effect size to see the effect. Paired ttest showed there are significant differences in knowledge and behavior before and after education in the intervention group (p<0.05). The Independent ttest showed there were differences in knowledge and behavior changes in the control and intervention groups (p<0.05). Test results (effect sizes 0.8 and 0.9) show DM education has an effect on changes in knowledge and preventive behavior. Changes in knowledge and behavior in the intervention group were higher than in the control group. The education provided has a strong influence on changes in maternal knowledge and behavior about dm prevention.
Strategy for Improving MSMEs Performance Through Stakeholder Involvement
Authors: Erni Yuningsih  , Sri Harini  , Endang Silaningsih
Published: May 2022

This study aims to identify MSMEs problems, identify internal and external factors, and recommend alternative strategies through stakeholder involvement. This research uses a participatory approach. Data obtained in the form of primary through observation, depth interviews, and FGD. Secondary data was obtained from other sources. Analyzing using IFAS, EFAS and SWOT analysis. Based on the IFAS EFAS score, the competitive ability of MSMEs is classified as moderate. The right strategy is to implement a growth strategy through horizontal integration. In contrast, the alternative approaches are institutional empowerment, increased development, intensive engagement with stakeholders, increased access to funding sources, marketing network development, conducive climate, improvement of entrepreneurship programs, improvement of production and information technology.
Prosthetic management of a Hemi-mandibulectomy patient with Definitive Removable Prosthesis - A case report
Authors: B Annapoorani , K Kasim Mohamed
Published: May 2022

The loss of continuity of the lower jaw following surgical excision of tumor results in deviation of remaining mandibular segment toward the resected side. Swallowing, speech, mastication, and mandibular movements are adversely affected by mandibular surgery. Prosthetic rehabilitation plays a major role in these patients, by fabricating the whole array of prostheses to meet specific patient needs. This case report describes about the patient diagnosed with squamous cell carcinoma of alveolus on the left side. The patient had undergone hemimandibulectomy followed by soft tissue reconstruction. As a result, mandible deviated to the affected side with trismus due to scar contraction. Second surgery was planned to remove the scar tissue and to improve mouth opening. Few days following second surgery, guiding flange prosthesis was fabricated to reduce the deviation and to guide the mandible close to occlusion. After three months, a removable cast partial prosthesis was fabricated, for the defect side which was supported by a wing to compensate for lack of underlying structures. It is imperative to provide such patients with guiding flange prosthesis three to four weeks after surgical management to guide mandible to occlusion and minimize the mandibular deviation. Failure to do so will complicate the occlusion. Subsequently patient can be rehabilitated with removable prosthesis to restore the function
Cu-Sil Denture – Replacement through Preservation
Authors: A Jenie Rosna , PS Manoharan , Koppolu SaiKiran , R Varsha
Published: May 2022

Esthetics along with function is the two most common concerns of patients. The need for patient’s esthetical concern should also be given prime concern when restoring the function. In most instances there is a need for irreversible alteration in the remaining hard tissue during a prosthodontics treatment. Preservation of natural teeth is gaining importance in dentistry in the present time. Diagnostic wax up and proper treatment planning is an important tool to establish the desired esthetic changes, to know how the final prosthesis looks like and for better understanding of the patient. This is a case report on a simplified approach in preservation of teeth and alveolar ridge along with esthetical correction of smile made with a newer type of transitional denture. It helps in promoting positive mental attitude among the patients by avoiding extractions.
The Effect of Albuterol with Heliox versus Albuterol Nebulization in Acute Asthma Exacerbation: A Randomized Controlled Clinical Trial
Authors: Motamed Hassan , Forouzan Arash , Masoumi Kambiz , Sajadi Rozbeh
Published: May 2022

Introduction: Asthma is one of the most common chronic disorders of the respiratory tract. Thus, this study intended to evaluate the clinical effects and the peak flow metric effects of nebulized albuterol with heliox versus albuterol nebulization in acute asthma exacerbation. Material and Methods: In this randomized clinical trial study, 109 patients with acute asthma attacks admitted to the emergency departments (EDs) in *** were enrolled. The patients were divided randomly into two groups: the intervention and control groups. The intervention group was nebulized with heliox (helium/oxygen-70: 30) plus albuterol with a 10 mL/min dose for 20 min three times, which lasted 60 min. The control group received standard treatment (albuterol in combination with oxygen). Results: The results showed that the mean scores of FEV1 and PEFR after 20 min were significantly different in the two groups, as FEV1 scores in the intervention group were 2.76 and 3.01 at 20 and 60 min, respectively, while FEV1 scores in the control group were 1.99 and 2.64, respectively (p < 0.001). In addition, PEFR scores in the intervention group at 20 and 60 min were 299.24 and 310.57, respectively. However, these scores in the control group were 237.98 and 274.56, respectively (p < 0.001). Conclusion: The results showed that the use of heliox in t eating severe asthma attacks could be regarded as a different standard treatment that can lead to significantly better control of asthma attacks in the short term.
Effectiveness of Upper Limb Exercises and Breathing Exercises in COPD Stable Patients During COVID-19 Pandemic Era
Authors: Tarigan Amira Permatasari , Pandia Pandiaman , Tarigan Agi Hidjri , Eyanoer Putri Chairani
Published: May 2022

Introduction: The objectives of study are to study and to evaluate the benefits and effectiveness of home-based pulmonary rehabilitation in compliance with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 nonpharmacological initiative for Chronic Obstructive Pulmonary Disease (COPD). Material and Methods: This study was a quasi-experiment conducted from August to November 2020 involving 10 COPD stable patients. In the first meeting at the hospital, patients were taught breathing techniques and upper-limb exercise movements which subsequently had to be done and recorded at home. Patients then sent the videos to the research team via whatsapp to be evaluated. Prior to starting the 4-week with twice-a-week frequency home-based rehabilitation, and again at the end of it, patients’ conditions were evaluated based on the following factors: lung functional capacity was measured by 6MWD (6 Minutes Walking Distance), Perceived Exertion Scale by mMRC (modified Medical Research Council) and Borg, the quality of life by SGRQ (St. George’s Respiratory Questionnaire) index, the severity of symptoms by CAT (COPD Assessment Test) and changes in muscle mass. Statistical analysis was conducted using the Wilcoxon and paired t-test. Results: After 4 weeks of home training with twice-a-week frequency, the results showed significant improvement, with p-value < 0.05, in the increased 6MWD value (16.4 ± 4.45 to 19.8 ± 3.64), mMRC (1.90 ± 1.10 to 0.90 ± 0.87), Borg (3.05 ± 1.53 to 1.40 ± 1.42), CAT (15.7 ± 6.63 to 11.8 ± 5.24) and muscle mass (28.36 ± 2.89 to 31.86 ± 3.97). Conclusion: The method produced positive outcomes in patients’ lung function capacity, severity of symptoms, exertion scale, muscle mass, and general quality of life. Accordingly, the home-based rehabilitation programme was as effective as the programme conducted at health-care centers.
Relative wage premium as a result of residence relocation of university graduates
Authors: Rocki Marek
Published: May 2022

Changing the place of residence after obtaining a university degree is one of the components of a broader issue of internal migration. The migration of people with higher education is a popular object of research, but until recently there were no data on migration immediately following graduation. The aim of the article is to demonstrate the occurrence of a relative wage premium related to this migration within a year after graduating, i.e. an increase in earnings resulting from moving to a different city. The study focused on groups of people who obtained their diploma in 2018 in the most popular fields of study within economics and technical sciences. An appropriate aggregation of data was made from the Polish Graduate Tracking System using the Social Insurance Institution (ZUS) data. It has been shown that the values of the relative earnings index for the analysed fields of study determined in this system were always higher for people who after obtaining their diploma in 2018 lived in 2019 in a voivodship other than their place of study, compared to those who remained in the powiat of their alma mater. This indicates the economic determinants of migration, i.e. the wage premium, related to the relocation of residence after obtaining a diploma.
Značaj porodice kao faktora u savremenim teorijama delinkventnog ponašanja dece i mladih
Authors: Terek Lidija
Published: May 2022

Rad ima cilj da objasni značaj porodice kao faktora u vodećim mikro- i makro-teorijama porekla delinkvencije i da utvrdi uloge koje joj one dodeljuju u objašnjenju etiologije ovakvog ponašanja. Analiza je pokazala da mikro-teorije kao posebno značajnu ističu socijalizaciju i vaspitnu ulogu porodice kojom se oblikuju kako konformistički, tako i antisocijalni obrasci ponašanja, dok makro-teorije glavne uzroke devijantnosti pronalaze u strukturalnim karakteristikama društva, a porodicu prepoznaju kao faktora koji posreduje između društva i deteta. Analizom su utvrđeni i nedostaci proučavanih teorija. S obzirom na to da se baziraju na istraživanjima sprovedenim u SAD-u i zapadnoevropskim zemljama, one ne mogu u potpunosti da se primene na objašnjenje etiologije delinkvencije u svim društvima. Pored toga, mikro-teorije ne uzimaju u obzir karakteristike društva koje mogu da utiču na izbor vaspitnih metoda roditelja, razvoj njihovog vaspitnog stila i na njihovu odluku koje vrednosti će da prenesu deci, dok se makro-teorije ne bave pitanjem kakav uticaj imaju na devijantno ponašanje odlike onih društava, čiji su ekonomski, pravni i kulturni sistemi decenijama nestabilni, kao ni onih čiji se društveni sistem urušio i još uvek se nije reetablirao. Na osnovu ove analize može da se zaključi da uprkos važnoj ulozi koju roditelji imaju za usvajanje/sprečavanje antisocijalnog ponašanja, okvire u kojima će oni tu ulogu obavljati određuju karakteristike datog društva.
Communicative City Features in Technopole Development: A Case Study in Bandung, Indonesia
Authors: Sutriadi Ridwan , Aziz Fajar Nurghifari , Ramadhan Afrizal
Published: May 2022

The ‘communicative city’ and ‘technopole’ concepts are important in current urban development strategies since they deal with optimizing information as well as improving knowledge to support the planning process. This study aimed to identify the extent to which the features of a communicative city are present in the initial development of the Gedebage Technopole area in Bandung, Indonesia. Using a qualitative research approach, we found that some communicative city characteristics, namely, community attachment, potential to create economic activities, considering culture and history, and communication patterns, are present in the development. Interactions among the development actors display a simple triple helix model, where the government, academia, and the business sector perform their respective roles. However, communication patterns and active synergies among the actors have not been created optimally to support the initial development of the Gedebage Technopole area. Recognizing the development actors are vital because the key to the success of a technopole lies in the contribution of all actors involved and the synergy between them. This will affect the existence of a multiple helix ecosystem as a sustainable regional competitiveness engine.
Protective action of polysaccharides from Laurencia papillose (Rhodophyta) against imidacloprid induced genotoxicity and oxidative stress in male albino rats
Authors: Abdelhafez Hossam El Din H. , AbdAllah Amr A , Afify Mostafa M , Mahmoud Naglaa F , Guo Jiangfeng , Murad Soha A , Ibrahim Eman A
Published: May 2022

Imidacloprid (IMI), the main component of neonicotinoid insecticides, promotes oxidative stress and genotoxicity in mammals. The aim of this experiment is to assess oxidative stress in liver cells and genotoxicity of erythrocytes for rats exposed to sub-lethal doses of IMI and the protective effects for Rhodophyta as antioxidant material versus imidacloprid. A total of 30 adult male albino rats (average body weight, 190-200 g) were divided into six groups (n=5) as follows: group 1 served as the control, group 2 received 200 mg/kg red algae, group 3 received 45 mg/kg IMI (high-dose group), group 4 received 22.5 mg/kg IMI (low-dose group), group 5 received 200 mg/kg red algae +45 mg/kg IMI, and group 6 received 200 mg/kg red algae +22.5 mg/kg IMI. After 28 d of treatment, the antioxidant activity of the crude extract of red algae was assessed in terms of free radical scavenging activity and found to be higher in TCA (75.57%) followed by DPPH (50.08%) at concentration 100 μg extract and a significant increase in lipid peroxidation and reductions in glutathione were observed in liver cells were intoxicated with high and low doses of IMI. Moreover decreases in catalase and glutathione peroxidase parameters in same previous groups which indicated oxidative stress. In addition significant increases in micronucleus frequency (MN) in the bone marrow of the rats as a genotoxicity marker which indicated DNA damage in erythrocytes cells with alterations in the histopathology of liver cells were also noted such as necrosis, inflammatory cells, infiltration, and necrobiotic changes. Whereas Rhodophyta succeeded in alleviation the oxidative damage and genotoxicity induced by the insecticide. In conclusion, IMI demonstrates hazardous effects, such as alterations in antioxidant status and mutagenicity of erythrocytes and polysaccharides from Rhodophyta has good antioxidant activity in vivo model systems against imidacloprid.
Die Wohnungsfrage
Authors: SIEBEL WALTER
Published: May 2022

Die Wohnungsfrage entstand im 19. Jahrhundert unter den so grundlegend geänderten Verhältnissen der industriellen Urbanisierung und ist heute wieder von brennender Aktualität. Sie beinhaltete von Anfang an zwei Fragen: Was kann menschenwürdiges Wohnen heißen, und wie kann die Masse der Wohnungssuchenden mit entsprechendem Wohnraum versorgt werden? Beide Fragen lassen sich nicht endgültig beantworten. Sie stellen sich im Zuge sozialer und politischer Veränderungen immer wieder neu. Aber was man die grundsätzliche Unbeantwortbarkeit der Wohnungsfrage nennen könnte, bedeutet keineswegs, dass Wohnungspolitik keinen Unterschied macht. Deshalb unterscheidet der Autor vier Phasen der Wohnungspolitik und die korrespondierenden – auch politisch bedingten – Veränderungen des Wohnungsmarkts in Deutschland: Ansätze einer Politisierung der Wohnungsfrage vor dem Ersten Weltkrieg, das „goldene Zeitalter der Wohnungspolitik“ in der Weimarer Republik, der allmähliche Rückzug der Politik und der Abbau eines marktfernen Segments der Wohnungsversorgung in der BRD und die Finanzialisierung des Wohnungsmarkts seit 2000. Am Schluss stehen Argumente zur „Unbeantwortbarkeit der Wohnungsfrage“ und Überlegungen zur Rolle der Gewerkschaften.
A Review on Vacuum-Powered Fluidic Actuators in Soft Robotics
Authors: Joe Seonggun , Bernabei Federico , Beccai Lucia
Published: May 2022

In the past few years, vacuum-powered soft actuators have shown strong potential due to their promising mechanical performance (i.e., fail-safe, fast response, compactness, robustness, jamming, etc.). Indeed, they have been widely exploited in soft robots, for example, grippers and manipulators, wearable devices, locomotion robots, etc. In contrast to inflatable fluidic actuators, the properties of the materials with which they are built have a stronger influence on the kinematic trajectory. For this reason, understanding, both, the geometry and morphology of the core structure, and the material characteristics, is crucial to achieving the desired kinetics and kinematics. In this work, an overview of vacuum-powered soft fluidic actuators is provided, by classifying them as based on morphological design, origami architecture, and structural instability. A variety of constitutive materials and design principles are described and discussed. Strategies for designing vacuum-powered actuators are outlined from a mechanical perspective. Then the main materials and fabrication processes are described, and the most promising approaches are highlighted. Finally, the open challenges for enabling highly deformable and strong soft vacuum-powered actuation are discussed.
Approaches to Enhance Therapeutic Activity of Drugs against Bacterial Biofilms
Authors: Veintramuthu Sankar , Ravi Mahipriya Selliamman
Published: May 2022

Biofilm may be a consortium of microbial species where the cells of microbes attach to both life form and inanimate surfaces inside a self-made matrix of extracellular polymeric substance (EPS). Biofilm matrix surrounding the polymicrobial environment makes them highly resistant to harsh conditions and antibacterial treatments. The two significant factors that differentiate planktonic from biofilm resident microbes are EPS containing a variety of macromolecules and a diffusible molecule for transferring signals known as quorum sensing (QS). Against this backdrop of microbial resistance and cell signaling, different approaches have been developed to interfere with the specific mechanisms of intracellular and extracellular targets that include herbal active compounds and synthetic nanoparticles. This chapter outlines the features of biofilm development and the approaches with the evidence that can be incorporated into clinical usage.
Carotenoids in Thermal Adaptation of Plants and Animals
Authors: M. Petyaev Ivan
Published: May 2022

The support of carotenoids in photosynthesis is well documented. However, what is their role in parts of plants where there is no photosynthesis such as in fruits or stems or even in parts which are not exposed to the light at all, such as seeds or roots? Why are carotenoids essential for all animals and humans and present in almost every tissue in their body? The answer is that carotenoids can make complexes with lipids, which results in an increase of lipid thermal energy absorption and a reduction of viscosity. These changes help to expand the temperature range for the functionality of lipid structures, improve the capacity of thermal homeostasis and support adaptation and survival of living species to environmental stress and in particular to temperature variations. Working as “thermal antennas” carotenoids can increase lipid thermal energy conductivity, heat storage and heat retaining capacity. This, on the one hand, can reduce the freezing/melting points of plant and animal lipids and makes carotenoids work as antifreezers in microorganisms, plants or ectothermic animals. On the other hand, the thermal antennas can help absorb, transmit and accumulate external thermal energy essential to activate and support cellular metabolism. In addition, we describe how these properties of carotenoids can affect lipid parameters in nutrition, physiology and pathology.
Mechanical Methods of Producing Biomaterials with Aligned Collagen Fibrils
Authors: Yunoki Shunji , Kondo Eiji , Yasuda Kazunori
Published: May 2022

Collagen has been used in various therapeutic medical devices, such as artificial dermis, bone, and cartilage, wherein the effectiveness of collagen mainly depends on its biological features of biocompatibility, biodegradability, bioresorbability, cell affinity, and weak antigenicity. Collagen is the main structural protein in the human body and is responsible for the mechanical properties of tissues and organs. The fundamental structural component of tendon tissue is uniaxially aligned collagen fibrils that run parallel to the geometrical axis. Thus, the fabrication of artificial tendons is an excellent example of developing biomaterials using collagen as a structural backbone. Previous attempts to construct aligned fibril-based biomaterials involved electrospinning, freeze drying, using a strong magnetic field, and mechanical methods, including shearing and tension during wet extrusion. Among these, mechanical methods have been extensively studied owing to their simplicity and effectiveness suitable for mass production. However, few review articles have focused on these mechanical methods. Thus, this article reviews the mechanical methods for creating biomaterials from aligned collagen fibril while discussing the other fabrication methods in brief.
Electromagnetic Fields Change the Expression of Suppressor of Cytokine Signaling 3 (SOCS3) and Cathepsin L2 (CTSL2) Genes in Adenocarcinoma Gastric (AGS) Cell Line
Authors: Mousavi Maleki Nafiseh Sadat , Entezari Maliheh , Abdi Soheila , Tekiyehmaroof Neda
Published: May 2022

Background: Gastric cancer is one of the most prevalent and deadliest cancers in the world. Environmental factors including chemicals, sunlight, and electromagnetic fields can induce changes in gene expression. Though the resizing mechanism of its effect has not been fully recognized, free radicals are seen as the possible mechanism involved. Although low-frequency electromagnetic fields are not considered a carcinogenic factor, some studies have shown disruption in deoxyribonucleic acid (DNA) and gene expression in different cell categories. Objectives: This study was intendant to examine the effects of low-frequency electromagnetic flux densities of 0.2 and 2 mT on the expression of cathepsin L2 (CTSL2) and suppressor of cytokine signaling 3 (SOCS3) genes in adenocarcinoma gastric (AGS) cell lines. Methods: The AGS cell line was cultured in Hamas12 and was exposed to electromagnetic fields continuously and discontinuously for 18 hours. Moreover, Cell viability was assessed by the MTT (3-(4, 5-Dimethylthiazol-2-yl)) assay. The change in the expression of genes was measured by real-time polymerase chain reaction (PCR). Results: Low-frequency electromagnetic fields increased gene expression compared to the control group. The changes in the expression are directly associated with the electromagnetic field strength. Expression levels of CTSL2 were increased under the exposure of electromagnetic fields and this increase was significant when discontinuous exposure was applied (33.26 ± 7.4 fold change for 0.2mT and 64.4 ± 7.7 for 2mT, p- value
New Cytotoxic Premyrsinane-Type Diterpenes from Euphorbia aleppica Against Breast Cancer Cells
Authors: Zolfaghari Behzad , Farahani Ali , Jannesari Amin , Aghaei Mahmoud , Ghanadian Mustafa
Published: May 2022

: Euphorbia is used in traditional medicine to remove warts, possibly due to its cytotoxic or antiviral effects. This study investigated its phytochemistry and bioactive compounds. Euphorbia aleppica from the Euphorbiaceae family was collected from Kuhdasht, Lorestan, Iran. Plant material was dried and ground. Extraction was performed by maceration using a dichloromethane-acetone solvent. After removing fatty contents, fractionation was done by open column chromatography. Based on the initial H-NMR spectra, fractions containing diterpenoid compounds were identified. The Sephadex column and HPLC performed isolation. The HPLC was done with a regular YMC silica column using a hexane: Ethyl acetate (70: 30) solvent. The selected sub-fractions were identified by one and two-dimensional corelative NMR spectra. Accurate mass spectra confirmed the molecular formula of the obtained structures. Cytotoxicity was assessed using a standard MTT assay against breast cancer cells. The NMR and mass analysis identified compound 1 as a newly described and compound 2 as a pre-defined compound as 3, 7, 15β-triacetyl-5α-tigliate-13(17)-α-epoxy-14-oxopremyrsinane and 3, 7, 14, 15, 17-pentaacetyl-5-tigliate-13(17)-epoxypremyrsinane, respectively. Compound 1 showed moderate cytotoxicity, and compound 2 exhibited a potent cytotoxic effect dose-dependently against MCF-7 and MDA-MB 231 breast cancer cells, probably because of 14-O-acetyl and 17-O-acetylated hemiacetal groups.