bluuebunny/crossref_metadata_2025 huggingface dataset:
Проблемы государственного регулирования рынка финансовых услуг
Authors: Галеева Д.Д. , Кузьмина О.Ю.
Published: April 2024

Научная статья посвящена проблемам государственного регулирования рынка финансовых услуг в условиях влияния COVID–19 и СВО на Украине на основных участников рынка. Раскрывается современное состояние политики регулирующих органов, а также успешный опыт отечественных субъектов финансового рынка в борьбе с негативными факторами внешней среды, что свидетельствует об эффективном управлении рынком финансовых услуг. Несмотря на принятые меры в области государственного регулирования прослеживаются некоторые проблемы, которые требуют детального рассмотрения в академических кругах.
Внутренние и внешние факторы, определяющие уровень экономической безопасности бизнеса
Authors: Коцкиева Л.А. , Ситохова Т.Е.
Published: April 2024

Данная статья исследует внутренние и внешние факторы, которые влияют на уровень экономической безопасности бизнеса. Исследование также обсуждает взаимосвязь между внутренними и внешними факторами, подчеркивая, что успешное обеспечение экономической безопасности бизнеса требует учета и управления обоими видами факторов. Это подразумевает не только разработку и реализацию стратегий и методов внутреннего управления, но и анализ внешней среды, прогнозирование изменений и принятие соответствующих мер.
Отчет о финансовых результатах по РСБУ и МСФО: общее и основные отличия
Authors: Лукина Е.В.
Published: April 2024

В статье приведен перечень показателей, которые должны быть представлены в Отчете о финансовых результатах по Российским стандартам бухгалтерского учета (РСБУ) и в Отчете о прибыли или убытке и прочем совокупном доходе по Международным стандартам финансовой отчетности (МСФО). Описаны отличия в формировании Отчета о финансовых результатах по РСБУ и Отчета о прибыли или убытке и прочем совокупном доходе по МСФО.
Финансовое обеспечение инвестиционной деятельности современных российских корпораций
Authors: Набока Д.С. , Савицкая М.А.
Published: April 2024

Любые управленческие решения в бизнесе так или иначе связаны с необходимостью обеспечения их соответствующими финансовыми ресурсами. Таким образом, для инвестиционной деятельности современных российских корпораций первостепенную роль имеют вопросы еѐ финансового обеспечения и успешной реализации. В данной статье рассматриваются наиболее популярные источники и инструменты финансирования, а также их особенности и способы привлечения. Немаловажно отметить тот факт, что стремительно меняющаяся экономическая среда, нестабильные финансовые рынки, а также изменяющиеся законодательные нормы создают вызовы для корпораций в области финансирования инвестиций. В этой связи, ключевым направлением совершенствования российской экономики является повышение эффективности инвестиционной деятельности корпораций за счет внедрения современных способов ее финансового обеспечения.
Уголовно-исполнительной политики современного Кыргызстана
Authors: Абдуразаков Х.К. , Нарматов Х.Б. , Махмудов А.Н.
Published: April 2024

В научной статьи авторами рассматривается уголовно-исполнительная политика, проводимая в Кыргызской Республики. Так, в любом современном демократическом обществе уголовная – исполнительная политика имеет свои непосредственные цели, задачи, стратегию, принципы все это необходимо для обеспечения исполнения отбывания всех видов уголовных наказаний. Для осуществления государственной политики в сфере борьбы с преступностью выделяются направления уголовная, уголовно-исполнительная и деятельность государственных органов в сфере предупреждения преступности. Каждая из перечисленных направлений может в процессе деятельности объединятся в необходимых случаях разъединятся, но в конечном итоге они выполняют в государстве одну из самых главных задач это борьба с преступностью. Тем самым уголовно-исполнительная политика тесно взаимодействует с уголовной политикой государства.
Международные торговые отношения в условиях санкционной политики
Authors: Петрушина А.А. , Казаченок О.П.
Published: April 2024

В статье рассматривает ситуация на международном рынке в связи с принятием санкций против Российской Федерации. Даѐтся краткий анализ экономической ситуаций в разные временные промежутки: с 2014 по 2021 года. Разбираются методы преодоления санкционной политики и существующие проблемы при исполнении контрактов, заключенных до введения санкций.
Условно досрочное освобождение и замена более мягким видом наказания: сходства и различия
Authors: Савин А.А.
Published: April 2024

Новые экономические, геополитические и социальные вызовы складывающихся отношений настоятельно требует кардинального реформирования отечественной законодательной системы РФ. Это связано с рядом факторов, в частности, экономическими, когда очевидная перегруженность пенитенциарных учреждений требует значительных финансовых затрат на содержание заключенных. В таких случаях условно-досрочное освобождение или замена наказания могут помочь оптимизировать расходы, направив средства на другие социально значимые цели. Социальными - когда система исправительной политики должна быть ориентирована не только на наказание, но и на реабилитацию осужденных. И политическими, когда Россия стремится к уважению прав человека и соблюдению международных норм в этой области.
Актуальные проблемы в информационно-коммуникационных технологиях и информационной безопасности в юридической деятельности
Authors: Чирьев И.С. , Жукова П.С. , Агеев Н.В.
Published: April 2024

В настоящей научной работе авторами исследуется вопрос об актуальных проблемах в информационно-коммуникационных технологиях и информационной безопасности в юридической деятельности. Информационные технологии получили свое повсеместное развитие со второго десятилетия XXI в. Они характеризуются крайне прогрессивным характером развития. В настоящее время практически невозможно представить какую-либо сферу общественной жизни, которой не коснулись бы информационные технологии. Тем не менее, несмотря на стремительное развитие информационных технологий вопросам безопасности их использования, защите персональных данных граждан не уделено достаточного внимания. Существует ряд проблем, связанных с использованием информационных технологий в ходе юридической деятельности: уязвимости в системах хранения и обработки данных, кибератаки и хакерские атаки на информационные системы юридических организаций, государственных органов, образовательных учреждений, отсутствуют актуальные законодательные нормы и правила в области информационной безопасности, которые могли бы эффективно регулировать использование информационных технологий в юридической сфере.
Понятие института амнистии в российском уголовном праве
Authors: Шаназарова Е.В.
Published: April 2024

В статье рассматривается институт амнистии в российском уголовном праве. Под актом амнистии рассматривается документ, издаваемый Государственной Думой вместе с комментариями к нему и содержащий решение о применении мер избавления от уголовного наказания или его смягчения в отношении численно неограниченного контингента подсудимых и отчужденных лиц, соответствующих конкретной диспозиции. Иными словами, в акте амнистии отображаются не конкретные люди, а перечень характеристик, которыми должен обладать субъект, содержащийся в изоляции от общества или подвергнутый судебному разбирательству, чтобы подходить для применения мер, изложенных в данном документе.
О квалификации преступлений против половой неприкосновенности несовершеннолетних, совершенных с использованием беспомощного состояния (на примере следственной и судебной практики)
Authors: Яшков С.А.
Published: April 2024

В настоящей статье анализируется уголовно-правовая оценка действий виновных, посягающих на половую неприкосновенность несовершеннолетних. На примере следственной и судебной практики автором показываются сложности, которые могут возникнуть при расследовании указанной категории дел.
The peculiarity of female crime
Authors: Agafonova T.S. , Dmitrienko N.A.
Published: April 2024

The article touches upon a very urgent problem of women’s crime. Crime is a social phenomenon that affects badly the Russian state law principles. Female crimes are usually connected with low levels of morality in our society. They can be the main criteria estimating cultural values existed in a modern society. The literary review let us determine female crimes as illegal actions committed by women. The relevance and peculiarities of female crime are described. The authors conclude that it is possible prevent crimes based on the peculiarities of women’s psychology.
Цифровое рабство или цифровая свобода?
Authors: Догонова Н.А.
Published: April 2024

В статье автор рассматривает такие понятия как «цифровое рабство» и «цифровая свобода» в контексте глобализации мировой экономки и гиперподключенностью в «новую нормальность» в основе которой лежит цифровая социализация. В статье затрагиваются вопросы цифровой экспансии, кастомизированные услуги, комфортные экосистемы. Автор анализирует нормативно-правовые акты обеспечивающие цифровые права и свободы граждан.
ATIVIDADE FÍSICA E COMPORTAMENTO SEDENTÁRIO EM TRABALHADORES DA ATENÇÃO PRIMÁRIA À SAÚDE NO ISOLAMENTO SOCIAL
Authors: Rossi Squarcini Camila Fabiana , Dias Cordeiro Maria Luisa , Santiago dos Anjos Soraya Dantas , Gomes Moscardini Daniela Simões , Farias Xavier Isabelle , De Amaral Macedo Danielle , Vasconcelos Rocha Saulo , Ohara David
Published: April 2024

Objetivo: avaliar o estilo de vida para a atividade física (AF) e o comportamento sedentário (CS) de trabalhadores da APS e também o impacto das características sociodemográficas, profissionais e de doenças nesses estilos no período antecessor a vacinação em massa da COVID-19. Método: De corte transversal, participaram 32 trabalhadores da APS de Itabuna-BA que responderam um questionário on-line. Foi realizada análise descritiva e teste Exato de Fisher, sendo p<0,05. Resultados: Observou-se a predominância de mulheres (86%), com 37,05 ± 9,22 anos, preta/pardas (69,8%), com até 40 horas de trabalho semanal (76,7%), que apresentaram índices recomendados para AF (97,7%) e CS (83,7%). Entretanto, foi encontrada associação entre o CS no final de semana e alto nível de colesterol (p=0,03). Conclusões: Os trabalhadores encontravam-se ativos fisicamente e com baixos índices de CS. Ainda, o CS no final de semana apresentou associação com o colesterol alto, enfatizando a necessidade da redução desse comportamento.
APLICAÇÃO DAS ETAPAS DO PROCESSO DE ENFERMAGEM AO PACIENTE COM CÂNCER NA ATENÇÃO PRIMÁRIA
Authors: Gomes dos Santos Marisa , Maestri Eleine , Monteiro da Conceição Vander , Fernanda Santos Candido Thamirys , Biffi Priscila , Valeria de Oliveira Vargas Bitencourt Julia
Published: April 2024

RESUMO
Objetivo: Investigar a aplicabilidade do Processo de Enfermagem na atuação do enfermeiro no manejo ao paciente com diagnóstico oncológico no âmbito da APS em um município do Oeste Catarinense. Método: Estudo quantitativo e qualitativo, descritivo exploratório, desenvolvido nos Centros de Saúde da Família. A amostra totalizou em 33 participantes. A coleta de dados ocorreu entre setembro e outubro de 2022. Foi utilizada análise estatística descritiva, e a técnica do Discurso do Sujeito Coletivo. Resultados: Os enfermeiros explicitam as dificuldades para realização do Processo de Enfermagem, considerando a aplicação de todas as suas etapas, e a relevância em ter um instrumento para orientar a consulta de enfermagem. Conclusão: Considerando o protagonismo dos enfermeiros, é possível e indispensável estruturar a assistência na APS, de modo a oferecer assistência resolutiva e de qualidade em todo o itinerário de acompanhamento do processo saúde-doença, aliançado entre os pontos de Rede de Atenção à Saúde.
Descritores: Atenção Primária à Saúde. Processo de Enfermagem. Enfermagem Oncológica.
Identification of Indigenous Lactobacillus fermentum by 16S rRNA Gene Sequencing Isolated from Two Different Ecosystems: Newborn Infants and Bee’s Intestine
Authors: Bahloul H.A. , Bekenniche N. , Zeriouh I.F. , Hadadji M. , Kihal M.
Published: April 2024

Background: The consumption of functional ferments that have functional characteristic sand contributes enormously to the safety and quality of food by offering several nutritional, technological and health properties. Lactobacillus fermentum (Lb. fermentum) is a Gram-positive bacterium belonging to the genus Lactobacillus and many are said to have the effect of preventing gastro-intestinal infections and improving immunological response. Additionally, Lb. fermentum produces diverse and potent antimicrobial peptides which can be applied as alternatives to antibiotics. Methods: In this study, samples were isolated from two different ecological niches, the first was feces of newborn infants (0-3 months) and the second from bee’s intestine, from south of Algeria : Ghardaïa 32°29'00" North, 3°41'00" East. Two indigenous lactic acid bacteria were isolated and evaluated for their probiotic properties. The isolate identification by sequencing 16S r DNA was performed using the universal primers 27F and 1492R. The NCBI Gen Bank database was used to have similarity of species. Result: The cultures showed good survival in simulated transit fluids as well as high acid and bile tolerance. The isolates also demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, the inhibition zone was measured between 10 mm and 20 mm of diameter respectively. Comparing the sequences of the isolates with the Gen Bank database (NCBI), a high percentage with species of Lactobacillus fermentum was shown.
The peri / postoperative analgesic effect of intravenous paracetamol in dogs
Authors: Mckay Laura
Published: April 2024

PICO Question
In healthy dogs undergoing a surgical procedure, is there improved pain control in dogs receiving intravenous paracetamol in the peri / postoperative period compared to dogs not receiving intravenous paracetamol?
 
Clinical bottom line
Category of research
Treatment.
Number and type of study designs reviewed
Three randomised, controlled, and blinded studies. Two studies directly address the PICO question whereby postoperative pain assessment was clinically evaluated following intravenous (IV) paracetamol. The third study addressed the question to a lesser extent, whereby the impact on the sevoflurane minimum alveolar concentration (MAC) reduction in response to noxious stimuli was assessed following the administration of IV paracetamol.
Strength of evidence
Weak.
Outcomes reported
The findings of the first two studies presented appear to directly contradict each other. The first study demonstrated a reduction in pain in all groups and found no differences in analgesia between IV paracetamol and other non-steroidal anti-inflammatories drugs (NSAIDs), while the second study reported no analgesia effects from IV paracetamol and was terminated prematurely because a high number of dogs required rescue analgesia. The first study reported sufficient analgesic effects of IV paracetamol and the second study reported no analgesia effects of IV paracetamol. Both were blinded, randomised, controlled studies and directly addressed the PICO question in relation to the peri / postoperative analgesic effects of IV paracetamol. However, their methods and sample sizes were very different. The third study did not demonstrate a clinically relevant sevoflurane MAC reduction after IV paracetamol in dogs.
Conclusion
At present, there is limited and weak evidence to suggest that IV paracetamol provides peri / postoperative analgesia in dogs. However, further studies are required to better assess its efficacy, its duration of action, and the appropriate doses that are necessary to reach therapeutic plasma levels. The reduced incidence of side effects at the currently recommended doses could support its peri / postoperative use, where NSAIDs use is contraindicated.
 
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
The Moderating Role of Technological Capabilities in the Relationship between Entrepreneurial Marketing and Firm Performance A Qualitative Approach
Authors: Fegada Alfateh , Veres Zoltan
Published: April 2024

Entrepreneurial marketing EM is a dynamic and innovative approach to marketing that is particularly well-suited for startups and small businesses. Thus, our study focuses on Sudanese SMEs in order to assist them in achieving profitability, sustainability, and competitive advantage in the long term. Consequently, our objectives are to develop the research pre-model and to explore in depth how entrepreneurs, managers, and employees of SMEs in Khartoum-Sudan are familiar with the concepts of the research pre-model, and how they can employ and take advantage of study concepts. To achieve these objectives, we relayed on the qualitative method an inductive approach to test the validity and to develop the research pre-model. Hence, we have designed an open-ended question scenario and conducted a certain interview utilizing multiple qualitative methods to gather the data from the purposive sample which consists of (15) individuals. We have divided the scenario into three main parts of questions, first open-ended questions about EM, in this regard the most important question that has been asked to the interviewees was “What are the factors/dimensions that comes to your mind when you hear about EM”? Secondly, open-ended questions about technological capabilities TCPs. “The commonly thought view of TCPs proposes that firms with strong technological capability can rapidly identify technological opportunities and the value of technological resources and utilizing modern equipment, in this scope benefits of entrepreneurial marketing should therefore be enhanced by a firm’s high technological capability”. e.g., “What are the expected advantages that will be rewarded by employing TCPs in SMEs”? Finally, we have grouped data into concepts, categories, and themes and then utilized a manual-thematic analysis as a method for identifying, analyzing, and interpreting patterns within data. In this scope we have analyzed the data and interpreted the results within three main themes. Accordingly, significant new dimensions have been discovered and generated which led to our final developed and adapted research model which can be shown in the body of study, Table 6.4.1 and Figure 6.4.1.
Intervenciones urbanas de Regiones Devastada: zona de Levante = Urban interventions of Regiones Devastadas: Levante area
Authors: Portalés Mañanós Ana
Published: April 2024

ResumenEl final de la Guerra Civil española supone el inicio de toda una serie de actuaciones encaminadas a recomponer el país, siendo una de las más importantes la reconstrucción de las ciudades que habían sido arrasadas por el conflicto bélico. En 1939 se crearon varios organismos de intervención estatal, entre ellos la Dirección General de Regiones Devastadas (DGRD). Este organismo contaba con una distribución administrativa descentralizada en oficinas comarcales que actuaban en los pueblos adoptados, agrupados geográficamente según zonas. El artículo es un extracto de una tesis que tiene por objetivo mostrar la obra promovida por la DGRD en la zona de Levante. Para ello, se expondrán los objetivos del organismo y las intervenciones desarrolladas en los pueblos adoptados en el conjunto del territorio español, así como las desarrolladas en Levante. Se ha recurrido a las fuentes originales de los proyectos a través de archivos públicos y privados, se han realizado visitas de campo a las distintas poblaciones, se ha contado con entrevistas de personajes próximos a los arquitectos participantes, y se ha hecho un vaciado de la revista Reconstrucción.  AbstractThe end of the Spanish Civil War marks the beginning of a whole series of actions aimed at rebuilding the country, one of the most important being the reconstruction of the cities that had been devastated by the war. In 1939, several state intervention agencies were created, including the Dirección General de Regiones Devastadas (DGRD). This organization had a decentralized administrative distribution in regional offices that operated in the adopted towns, grouped geographically according to areas. The article is an excerpt from a thesis that aims to show the work promoted by the DGRD in the Levante area. To this end, the objectives of the organization and the interventions developed in the adopted towns throughout the Spanish territory, as well as those developed in the Levant, will be explained. The original sources of the projects have been used through public and private archives, field visits have been made to the different towns, there have been interviews with people close to the participating architects, and an emptying of the Reconstruction magazine.
Functional Combination Based Comprehensive Benefit Evaluation of Energy Storage Projects under Source-grid-load Scenarios via Super Efficiency DEA
Authors: Qu Hong , Ye Ze
Published: April 2024

As an important support for power system with high penetration of renewable energy, energy storage system (ESS) has changed the traditional model of simultaneous implementation of electricity production and consumption, and its installed capacity under the source-grid-load scenario is rising year by year, but it faces the problems of insufficient utilization and benefits. This study analyzes the functional combination of ESS under the source-grid-load scenarios, and proposes a comprehensive benefit evaluation method of energy storage projects based on fuzzy decision-making trial and evaluation laboratory (DEMATEL) and super efficiency data envelopment analysis (DEA) model, which considers the perspective of economic and social environment. Firstly, the functional requirements of energy storage on the source-grid-load scenarios are explored respectively, and the characteristics of various functions are analyzed to form functional combination schemes. Secondly, index modeling is carried out from three aspects: the whole life cycle cost, functional combination benefit and social environmental benefit, and the comprehensive benefit evaluation index system of energy storage project is proposed, which includes both economic and social environment. Then, the intuitionistic trapezoidal fuzzy number is combined with DEMATEL to form an effective analysis method for the input-output relationship of the indexes, and the comprehensive evaluation is realized based on the super efficiency DEA model. Finally, the effectiveness of the proposed evaluation method and the rationality of the functional combination are verified under source-grid-load scenarios respectively.
Ecological Groups of Coleoptera (Insecta) as Indicators of Habitat Transformation on Drained and Rewetted Peatlands: A Baseline Study from A Carbon Supersite, Kaliningrad, Russia
Authors: Alekseev Vitalii , Napreenko Maxim , Napreenko-Dorokhova Tatiana
Published: April 2024

A total of 281 coleopteran species from 41 families were recorded from different sites of an abandoned cut-over peatland designated as the Carbon Measurement Supersite in Kaliningrad Oblast. This beetle assemblage is considered as a baseline (pre-impact) faunal assemblage for the further investigations during the ‘before-after’ (BA) or ‘before-after control-impact’ (BACI) study on a peatland that is planned to be rewetted. The spontaneously revegetated peatland has a less specialised beetle assemblage than at an intact raised bog. Tyrphobiontic species are completely absent from the peatland, while some tyrphophiles (5.3% of the total beetle fauna) are still found as remnants of the former raised bog communities. The predominant coenotic coleopteran group is tyrphoneutral generalists from various non-bog habitats (72.9%). The species composition is associated witho the structure vegetation of the disturbed peatland (fragmentary Sphagnum cover, lack of open habitats, and widespread birch coppice or tree stand), which does not correspond to that of a typical European raised bog. The sampled coleopteran assemblage is divided into several relative ecological groups, whose composition and peculiarities are discussed separately. Possible responses to the rewetting measurements in different coleopteran groups are predicted and briefly discussed. A complex assemblage of stenotopic peatland-specialised tyrphophiles (15 spp.) and the most abundant tyrphoneutral generalists (31 spp.) were assigned as indicators for the environmental monitoring of peatland development.
Pengaruh Likuiditas dan Financial Distress terhadap Agresivitas Pajak dengan Firm Size sebagai variabel Moderasi pada Perusahaan Badan Usaha Milik Negara yang Terdaftar di Bursa Efek Indonesia tahun 2018-2020
Authors: Feriyana Feriyana Maulida , Hasanah Nuramalia , Sariwulan Tuty
Published: April 2024

Penelitian ini bertujuan untuk menganalisis pengaruh likuiditas, financial distress dan firm size terhadap agresivitas pajak yang dimoderasi oleh firm size. Penelitian ini menggunakan data sekunder yaitu laporan tahunan perusahaan Badan Usaha Milik Negara yang terdaftar di Bursa Efek Indonesia periode 2018-2020. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah purposive sampling. Total sampel yang digunakan terdiri dari 45 data yang dianalisis menggunakan analisis regresi linear berganda dan analisis regresi moderasi menggunakan Statistical Program for Social Science (SPSS) versi 26. Hasil menunjukan bahwa secara parsial, likuiditas berpengaruh negatif signifikan terhadap agresivitas pajak, financial distress berpengaruh positif signifikan terhadap agresivitas pajak dan firm size tidak memiliki pengaruh yang signifikan terhadap agresivitas pajak. Dalam hal moderasi, hasil membuktikan bahwa firm size mampu memoderasi pengaruh likuiditas terhadap agresivitas pajak dan firm size tidak mampu memoderasi pengaruh financial distress terhadap agresivitas pajak.
Analisis Pengaruh Roa, Ekuitas dan Inflasi Terhadap Pendapatan dengan Pembiayaan Musyarakah sebagai Variabel Intervening pada Bank Mega Syariah di Masa Pandemi
Authors: Budianto Achyat , Ferawati Rofiqoh , Prayogo3 Youdhi
Published: April 2024

Penelitian ini  bertujuan untuk mengetahui pengaruh ROA, Ekuitas dan Inflasi terhadap pendapatan dengan pembiayaan Musyarakah sebagai variabel intervening pada Bank Mega Syariah di masa Pandemi. Sampel dalam penelitian ini bersumber dari laporan keuangan Bank Mega Syariah periode tahun 2020 sampai tahun 2022. Data dalam penelitian adalah data sekunder yang berjumlah 35 data. Pengujian hipotesis menggunakan analisis jalur dengan bantuan program Eviews. hasil penelitian menunjukkan variabel pembiayaan musyarakah mampu memediasi ekuitas berpengaruh terhadap pendapatan, Sedangkan ROA dan Inflasi tidak berpengaruh terhadap pendapatan melalui pembiayaan musyarakah
VALIDITY AND RELIABILITY OF BASIC MANIPULATIVE MOVEMENT SKILLS TESTS FOR EARLY CHILDREN 6-8 YEARS
Authors: Ashidiqie Dawam , Siregar Nofi Marlina , Sujarwo
Published: April 2024

Basic motor skills assessment tests are widely used, including tests of manipulative basic movement skills. The basic manipulative movement skill test is used to measure the basic manipulative movement skills of early childhood. The purpose of this study was to find out whether it is suitable and effective for measuring basic manipulative movement skills in early childhood 6-8 years. The sample population used in this study were 30 different early childhood children aged 6-8 years in Pecallan Village, Natar District, South Lampung. Construct validity and reliability were calculated using Pearson's correlation with the results obtained that the study included 4 indicators, namely throwing, catching, hitting, and kicking, the results obtained were r count > r table (28; 5%) = 0.361. So it can be stated that all the indicator items used are valid. And based on the reliability test with Cronbach alpha, a value of 0.806 > 0.7 is obtained, so that it represents that these items are reliable for measuring the sample. In conclusion, thus that the manipulative basic movement skills test can be used to measure basic movement skills in early childhood 6-8 years.
THE EFFECTIVENESS OF SOFTBALL OVERHAND THROW SKILL TRAINING MODEL ON BASIC THROWING SKILLS IN BLACK DIAMON CIREBON SOFTBALL PLAYERS
Authors: Elian Septo
Published: April 2024

The purpose of this study was to produce and test a softball overhand throw skill training model. The research method uses research and development methods adopted from the theory of Borg & Gall. There are ten steps used in this study, namely needs analysis, initial product development, expert evaluation, small group trials, product revisions, large group trials, product revisions, effectiveness tests, revisions, and the final product. The research subjects were u-17 novice athletes with a total of 15 subjects in small group trials, large group trials of 40 novice athletes and 40 subject effectiveness tests conducted on u-17 novice athletes at the Black Diamon Club Cirebon. The data analysis technique used in this study to test the effectiveness of the model is the normality test, homogeneity test and independent sample-test. The results of the research produced a product in the form of softball overhand throw skill training. For the 17 year old group, 24 training models have been validated and revised by experts. The implication of this study is that the training model is feasible and effective for use by the age of 17 and over in improving softball overhand throw skills.
Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes
Authors: Vivek Kavyesh , Kamal Rayan , Perera Edward , Gupte Chinmay M.
Published: April 2024

Background:

Vitamin D deficiency is increasingly identified as a predictor of poorer outcomes in musculoskeletal disease affecting as many as 1 in 4 people. This study aimed to evaluate the effect of vitamin D supplementation on outcomes after primary total knee arthroplasty (TKA).

Methods:

A targeted search of terms related to vitamin D and TKA outcomes was performed in PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, American Academy of Orthopaedic Surgeons, and British Orthopaedic Association databases. The results were analyzed using forest plots with I2 heterogeneity statistics and pooled effects with 95% confidence intervals (CIs) and p values. A p < 0.05 was considered statistically significant.

Results:

A total of 146,054 patients with 150,107 TKRs were analyzed in 10 studies that complied with the inclusion criteria, of which 3 were suitable for meta-analysis. Of these, 4 of the 10 studies showed that vitamin D deficiency resulted in poorer functional outcome scores (Western Ontario and McMasters Universities Osteoarthritis Index, Knee Society Scoring System, and American Knee Society scores), as well as increased risk of revision surgery, incidence of joint infection, and postoperative stiffness. Meta-analysis of length of hospital stay (LOS) demonstrated a significant increase in LOS in patients with vitamin D deficiency (standardized mean difference, −0.54, 95% CI, −0.69 to −0.38, p < 0.00001). Furthermore, outcomes were improved with vitamin D supplementation in 6 of 10 studies.

Conclusion:

Vitamin D deficiency results in poorer outcomes of primary TKA, with improved outcomes after supplementation. Further studies should examine the role of preoperative vitamin D screening and/or perioperative supplementation in primary TKA and standardize outcome measures to assess their effect.

Level of Evidence:

Level I/II. See Instructions for Authors for a complete description of levels of evidence.
Applied Data Analysis: A Problem-based Learning Approach
Authors: Smith Ann
Published: April 2024

This paper examines the transition of a conventional multivariate statistics module to a problem-based learning module, first implemented in 2021. The primary objective was to enhance students’ problem-solving skills, bridging the gap between mathematical concepts and real-world applications. The approach was implemented to instil a deeper understanding of real-world data analysis, emphasising the interpretation of domain specific problems in mathematical terms and the production of reports for industrial stakeholders.Findings indicate that the integration of problem-based methods not only improved students’ comprehension of statistical techniques but also fostered a more profound appreciation for their practical utility in diverse professional contexts. The problem-solving cycle, a central component of the approach, guided students in critically analysing complex challenges and formulating data driven solutions. Furthermore, this study emphasises the potential for replicating the industrial study group experience within an undergraduate teaching environment.Adopting a problem-based learning approach in the teaching of data analysis empowers students to apply their analytical skills effectively to real-world scenarios, strengthening their capacity to communicate insights and solutions to industrial stakeholders. The study underscores the value of aligning educational practices with the demands of data-driven industries, providing students with a competitive advantage in future research and the job market. The study is descriptive and reflective in nature.
Project-based learning integrated with e-Assessment
Authors: Derrick Ben , Weir Iain
Published: April 2024

This paper explores a recent move towards project-based learning for a first-year undergraduate statistics module at the University of the West of England, Bristol. The course is aimed at students specialising in Mathematics and Statistics. A classroom-based end of module project week was developed with the focus on project-based learning, supported by Dewis-R data generation and e-Assessments. Simulation of a practice-based environment with a dedicated working area and daily deadlines is incorporated to enhance the activity. Students are faced with a highly relevant statistical analysis task, that is large and has not had the prior data screening or cleansing that they may be accustomed to in basic didactic teaching. Indications are that the project-based learning approach, assessed during a project week with supplementary e-Assessments and a final report, is well received and leads to improved student outcomes.
WITHDRAWN: Numerical Study on the Performance Evaluation and Thermal Management of Automotive Exhaust Thermoelectric Generator using Pin fins
Authors: Veer Chander
Published: April 2024

The utilization of thermoelectric power generators presents a viable prospect for the recuperation of waste heat that results from exhaust gases within the automotive sector. The optimal performance of thermoelectric modules in waste heat recovery applications is heavily dependent on the design of the heat exchanger. The current study employs numerical methods to examine the efficacy of pin-fin configurations on the hot-side heat exchanger surface in enhancing heat transfer and thereby improving the conversion efficiency of TEG. Specifically, the study explores the impact of inline, staggered, and progressive arrangements of pin-fins in the direction of the exhaust stream. The heat exchanger is subjected to variations in fin thickness ranging from 10 mm to 18 mm to improve heat transfer in each configuration. The study conducts simulations on every fin configuration, utilizing three distinct inlet velocities (4 m/s, 6 m/s, and 8 m/s) and five different inlet temperatures (423 K, 473 K, 523 K, 573 K, and 623 K). The assessment of the heat exchanger’s performance is conducted by means of the thermalhydraulic performance coefficient (THPC) and the temperature uniformity index. Meanwhile, the evaluation of the TEG device’s performance is carried out by estimating its rated power output and the conversion efficiency of TEG. According to the findings, the staggered fin arrangement exhibits the highest Thermal Hydraulic Performance Coefficient (THPC) and power generation capability, while the progressive and inline fin configurations follow in descending order. The utilization of fins with a thickness of 18 mm in a staggered arrangement yields a peak rated power output of 53.42 W. The implementation of pin fins in a staggered configuration within the heat exchanger amplifies the heat transfer from the exhaust gas to the thermoelectric module. Consequently, there is an increase in the output power with respect to the given temperature difference.
Prenatal manifestation of Transient Abnormal Myelopoiesis in a genotypically normal fetus: case report and review of the literature
Authors: Walasik Izabela , Litwinska-Korcz Ewelina , Szpotańska Monika , Stanirowski Paweł , Księżopolska Aleksandra , Ludwin Artur , Litwinska Magdalena
Published: April 2024

Background: Congenital malignancies are unusual fetal conditions and therefore the data on their prenatal manifestation is limited. Transient abnormal myelopoiesis (TAM) is a hematologic disorder characteristic for babies with trisomy 21 and base on transient appearance of the blast cells in peripheral blood. This paper presents prenatal manifestation of congenital TAM in a genotypically normal newborn and reviews the literature on prenatal manifestation of this disorder.
Case presentation: A pregnant woman in her third pregnancy referred herself to the hospital for reduced fetal movements at 30 weeks of gestation. Admission’s ultrasound scan showed an increased middle cerebral artery peak systolic velocity (MCA PSV) together with hepatomegaly. The patient was admitted to the labor ward for cardiotocography monitoring which showed an acute fetal distress with repeated unprovoked decelerations. An emergency cesarean section was conducted and a phenotypically normal female newborn with low Apgar score was delivered. Further examination of peripheral blood revealed anemia and leukocytosis with high blast proportion. A bone marrow aspirate revealed 70.2% of blasts in a sample with an abnormal karyotype of 47,XX+21. Cytogenetic analysis of blasts with later microarray comparative genomic hybridizationconfirmed the presence of GATA1 mutation. However, the buccal smear showed a normal karyotype in the infant. The disease was classified as TAM. The literature review together with the case presentation showed that increased MCA PSV and hepatosplenomegaly are important risk factors of death in fetuses with TAM.
Conclusions: Our study demonstrates a rare case of prenatal manifestation of TAM in genotypically normal neonate. Obstetricians should pay attention to symptoms like high MCA PSV and hepatosplenomegaly as possible causes of fetal hematological disorders and differentiate it with infection or isoimmunization.
Prognostic role of plasma IL-17a expression and neoadjuvant therapy efficacy in breast cancer
Authors: Yu Liyan , Miao Huilai , Zeng Xiangning , Liu Guoqing , Xie Jiaxin , Liang Zhongzeng , Zhang Yuanqi
Published: April 2024

Background
Breast cancer (BC) is a common and highly malignant disease. Recently, IL-17a was found to be associated with several human malignancies. This study aims to investigate plasma IL-17a expression in BC and explore its role in disease progression and its interaction with neoadjuvant therapy efficacy.
Methods
Plasma IL-17a expression in BC tissue samples from 54 patients who received neoadjuvant therapy were analyzed and assessed using immunohistochemistry.
Results
Statistical analysis showed that a high expression of IL-17a before and after neoadjuvant therapy was positively correlated to poor responses (stable disease and progressive disease) (SD + PD). Conversely, IL-17a was significantly decreased in patients with good responses (complete response and pathologic partial response) (CR + PR) compared with patients with poor responses. Moreover, IL-17a was more easily decreased in patients with earlier stages. Furthermore, plasma IL-17a was positively correlated with poor prognosis (PFS) after treatment.
Conclusions
IL-17a is a potential biomarker of neoadjuvant therapy for BC.
RETRACTED: Green synthesis of gold nanoparticles using Benincasa hispida and evaluation of its anticancer activity against oral cancer cell line
Authors: Subbiah Usha , Ajith Athira , Subramani Karthikeyan
Published: April 2024

The authors have requested that this preprint be removed from Research Square.
Etiological Exploration of Enamel Defects: A cross-sectional study to Unravel Maternal, Prenatal, and Early Childhood Influences
Authors: Jeghami Rania Al , Al-Nerabieah Zuhair , Dashash Mayssoon
Published: April 2024

Background
Enamel developmental defects (EDs) significantly impact pediatric dental health. This cross-sectional study in Damascus explores the prevalence and etiological factors of EDs in Syrian children (ages 7 to 12).
Methods
Adopting a cross-sectional observational design, the study adhered to STROBE guidelines. A total of 2000 participants underwent clinical examination using the Enamel Defect Index (EDI). Phone interviews with families aimed to uncover etiological factors.
Results
Prevalence of EDs was 16.1%, with Localized Enamel Defects (LEDS) and Molar-Incisor Hypomineralization (MIH) being most common. Regional variations, parental education, and consanguineous marriage correlated with ED occurrence. MIH prevailed in higher economic strata.
Conclusion
This study sheds light on the prevalence and factors influencing EDs in Syrian children. While not establishing direct links with maternal health conditions, it underscores the intricate interplay of genetic and environmental factors. Further investigations are crucial for a nuanced understanding, informing preventive and intervention strategies in pediatric dental health.
Identification of a new HIV-1 circulating recombinant form (CRF159_01103) derived from CRF103_01B and CRF01_AE in Hebei Province, China
Authors: Fan Weiguang , Zhang Zhen , Shi Haoxi , Jia Jianru , Shi Penghui , Chen Sisi , Lu Xinli
Published: April 2024

Recombinant HIV-1 genomes identified in three or more epidemiological unrelated individuals are defined as circulating recombinant forms (CRFs). CRFs can further recombine with other pure subtypes or recombinants to produce secondary recombinants. In this study, a new HIV-1 intersubtype CRF, designated CRF159_01103, isolated from three men who have sex with men (MSM) with no epidemiological linkage, was identified in Baoding city, Hebei Province, China. CRF159_01103 was derived from CRF103_01B and CRF01_AE. Bayesian molecular clock analysis was performed on the CRF01-AE and CRF103_01B regions of CRF159_01103. The time of origin of CRF159_01103 was predicted to be 2018–2019, indicating that it is a recent recombinant virus. The emergence of CRF159_01103 has increased the complexity of the HIV-1 epidemic in Hebei Province.
Medical residents’ experiences with group biases in medical decision making: a qualitative study
Authors: Choi Justin J. , Mhaimeed Nada , Al-Mohanadi Dabia , Mahmoud Mai A.
Published: April 2024

Background
Systematic biases in group decision making (i.e., group biases) may result in suboptimal decisions and potentially harm patients. It is not well known how impaired group decision making in patient care may affect medical training. This study aimed to explore medical residents’ experiences and perspectives regarding impaired group decision making and the role of group biases in medical decision making.
Methods
This study used a qualitative approach with thematic analysis underpinned by a social constructionist epistemology. Semi-structured interviews of medical residents were conducted at a single internal medicine residency program. Residents were initially asked about their experiences with suboptimal medical decision making as a group or team. Then, questions were targeted to several group biases (groupthink, social loafing, escalation of commitment). Interviews were transcribed and transferred to a qualitative data analysis software. Thematic analysis was conducted to generate major themes within the dataset.
Results
Sixteen interviews with residents revealed five major themes: (1) hierarchical influence on group decision making; (2) group decision making under pressure; (3) post-call challenges in decision making; (4) interactions between teamwork and decision making; and (5) personal and cultural influences in group decision making. Subthemes were also identified for each major theme. Most residents were able to recognize groupthink in their past experiences working with medical teams. Residents perceived social loafing or escalation of commitment as less relevant for medical team decision making.
Conclusions
Our findings provide unique insights into the complexities of group decision making processes in teaching hospitals. Team hierarchy significantly influenced residents’ experiences with group decision making—most group decisions were attributed to consultants or senior team members, while lower ranking team members contributed less and perceived fewer opportunities to engage in group decisions. Other factors such as time constraints on decision making, perceived pressures from other staff members, and challenges associated with post-call days were identified as important barriers to optimal group decision making in patient care. Future studies may build upon these findings to enhance our understanding of medical team decision making and develop strategies to improve group decisions, ultimately leading to higher quality patient care and training.
Geometric factor analysis for dose distribution in the whole breast irradiation
Authors: Chen Feihu , Pan Xiang , Liu Xuhong , Wang Ru , Li Qianyan , Bai Han , Tan Simeng , Kong Yinwu
Published: April 2024

Background
Protecting the heart and left lung is important for left-sided breast cancer radiotherapy. So，this study was to investigate the effect of geometric parameters on the dose of left lung and heart in whole breast radiotherapy.
Methods
A plan was designed for each patient using VMAT technology for thirty patients. A triangular ABC of the target was defined layer by layer. The geometric parameters were defined: Rat-H (the ratio of heart), Rat-L (the ratio of lung), the curvature and thickness of the target ρ and d. Explored the relationships between these parameters and the dose-volume of heart (V5,h, V10,h, V20,h, MHD) and left lung (V5,LL, V10,LL, V20,LL, V30,LL, V40,LL, MLD).
Results The V5,h, V10,h and MHD were all significantly associated with Rat-H (p<0.05). The V5,LL, V10,LL, V20,LL, V30,LL, V40,LL and MLD were all significantly associated with Rat-L (p<0.05). And the V20,LL, V30,LL and V40,LL were all significantly associated with d (p<0.05). Meanwhile，V30,LL and V40,LL were all significantly associated with ρ (p<0.05) . The correlations of the dose-volume of left lung and the four geometric parameters could be expressed by linear functions.
Conclusions
The geometric parameters Rat-H, Rat-L, d and ρ were closely related to the dose-volume of heart and left lung in whole breast radiotherapy.
Learning from virtual experiments to assist users of Small Angle Neutron Scattering in model selection
Authors: Robledo José Ignacio , Frielinghaus Henrich , Willendrup Peter , Lieutenant Klaus
Published: April 2024

In this work we combine the advantages of Small Angle Neutron Scattering (SANS) Monte Carlo simulations with the recent advances in computer vision to generate a tool that can assist SANS users in form factor model selection. We generate adataset of almost 260.000 SANS virtual experiments of the SANS beamline KWS-1 at FRM-II, Germany, intended for Machine Learning purposes. Then, we train a recommendation system based on an ensemble of Convolutional Neural Networks to predict the form factor model from the two-dimensional SANS scattering pattern measured at the position-sensitive detector of the beamline. The results show that the CNNs can learn the form factor prediction task, and that this recommendation system has a high accuracy in the classification task on 46 different form factor models. We also test the network with real data and explore the outcome. Finally, we discuss the reach of counting with the set of virtual experimental data presented here, and of such a recommendation system in the SANS user data analysis procedure.