bluuebunny/crossref_metadata_2025 huggingface dataset:
RISK FACTORS FOR REFRACTORY BENIGN ESOPHAGEAL STRICTURES
Authors:   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco., Sair A. , Mrabti S. ,   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco., Benhamdane A. ,   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco., Addajou T. ,   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco., Berraida R. ,   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco., Sentissi S. ,   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco., Rouibaa F. ,   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco., Benkirane A. ,   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco., Seddik H. ,   Department of Gastroenterology II, Military Teaching Hospital Mohamed V, University of Mohamed V Rabat, Morocco.
Published: August 2023

Background: The management of patients with refractory benign esophageal stricture is time-consuming and challenging. Dilation is the classic treatment for esophageal strictures, expressed primarily as dysphagia, which can significantly impair quality of life.Our objective is to report the results of dilatation, as well as the different risk factors of refractory benign esophageal strictures. Methods: This is a single-center retrospective study. Thirty-three patients with benign esophageal strictures were treated by dilation between 2016 and 2021. Refractory stenosis was defined as the inability to maintain esophageal caliber at 14 mm diameter over 5 dilatation sessions, or the inability to maintain satisfactory luminal diameter for 4 weeks once a 14 mm diameter was achieved. Results: 12 patients had refractory strictures. All patients had dysphagia.After univariate analysis, refractory strictures were associated with the presence of a peptic stenosis (p=0.002) and dilatations of caliber less than 16 mm (p=0.012), after multivariate analysis only peptic stenosis was associated with refractory stenosis (p=0.034). Conclusion: In our series, refractory stenosis was present in 38.7%. Peptic stenosis was statistically significantly associated with refractory esophageal stenosis.
A STUDY ON MATERNAL AND PERINATAL OUTCOME IN ECLAMPSIA
Authors:   Department Of Obstetrics & Gynaecology, Government Medical College, Kota., Meena Shivraj , Goyal Preeti ,   Department Of Obstetrics & Gynaecology, Government Medical College, Kota., Mangtani Kratika ,   Department Of Obstetrics & Gynaecology, Government Medical College, Kota., Meena Priyanka ,   Department Of Obstetrics & Gynaecology, Government Medical College, Kota., Saxena Bharti ,   Hod & Senior Professor Department Of Obstetrics & Gynaecology, Government Medical College, Kota.
Published: August 2023

Introduction: Eclampsia is still amongst the six major determinants of maternal mortality. It is characterized by sudden onset of generalized tonic-clonic convulsion or coma in pregnancy or postpartum, unrelated to other cerebral conditions,in patients with signs and symptoms of preeclampsia. Eclampsia results in increased maternal morbidity and perinatal morbidity. Materials And Methods: This is a prospective hospital based observational study in which all women with eclampsia admitted in OBG department of tertiary care center over one year period from January 2021 to December 2021. Aims And Objectives: To study the incidence of eclampsia, maternal and fetal outcome in eclampsia, complications of eclampsia. Results: Mean age of study group was 23.9Â±3.55 SD.Majority of the cases were primigravida- 74 (61.66%). Majority of cases were unbooked- 112 (93.3%). Mean gestational age in study group was 35.11 Â± 3.24weeks.Majority of cases were antepartum eclampsia- 110 (91.66%)Caesarean delivery was needed in 74 (61.66%) and 46 (38.33%) delivered vaginally.The perinatal mortality is 29.03%. The maternal mortality is 4.16%. Conclusion: Eclampsia occurred in young unbookedprimigravidas in the antenatal period and its incidence is 1.32%. Women require care in HDU-ICU and need careful evaluation to decide the mode of delivery in the best interest of mother and the, to be born preterm baby.We still have a long way to go to improve the outcome of such mothers and infants by better high-risk assessment at peripheral hospitals, critical care ambulances for transfer of these women from periphery and improvement of critical care at our institution by training of our faculty and residents in critical care obstetrics.
KNOWLEDGE, ATTITUDE, AND PRACTICE OF HUMAN PAPILLOMA VIRUS VACCINATION AMONG PRIMARY HEALTH CARE PHYSICIANS IN AL AHASA, SAUDI ARABIA
Authors:   Family Medicine Residents at AlAhsa Family Medicine Academy, Ministry of Health, Saudi Arabia., Alhamoud Aishah , Alkhamis Amnah ,   Family Medicine Residents at AlAhsa Family Medicine Academy, Ministry of Health, Saudi Arabia., Bo Radha Monirah ,   Family Medicine Residents at AlAhsa Family Medicine Academy, Ministry of Health, Saudi Arabia., Alhaji Sukinah ,   Family Medicine Residents at AlAhsa Family Medicine Academy, Ministry of Health, Saudi Arabia., Bu-Khamseen Montaser ,   Faculty, AlAhsa Family Medicine Academy, Ministry of Health, Saudi Arabia., Alomran Asma ,   Faculty, AlAhsa Family Medicine Academy, Ministry of Health, Saudi Arabia., Almubarak Duaa ,   Faculty, AlAhsa Family Medicine Academy, Ministry of Health, Saudi Arabia.
Published: August 2023

Introduction:Human papillomavirus (HPV) has been linked to a variety of cancers in both men and women. HPV is a DNA virus that causes warts on the skin and mucous membranes. Some HPV strains can cause cancers such as anal, vulvar, vaginal, penile, and cervical cancer. All of these cancers are preventable if the vaccine is used correctly. In Saudi Arabia, two types of HPV vaccine are available: bivalent vaccine (Cervarix) and quadrivalent vaccine (Gardasil). The purpose of this study was to assess Saudi physicians knowledge, attitude, and practice regarding HPV vaccine. Method:A cross-sectional study was conducted in Saudi Arabia by 2022, with the studys target population being physicians working in primary health care settings in the Ministry of Health. The study included 385, however only 289 participants who worked in primary health care under the Ministry of Health, AlAhsa have responded. The Ethics Committee has approved the research. Results: Total 289 doctors working in AlAhhsa primary health care centers were included in the study, with 136 females (47.06%) and 153 male (52.94%). The majority of the participants, 259(89.62%), were Saudi, and almost half (49.83%) had less than 5 years of experience. Family medicine consultants and specialist had higher level of knowledge about HPV vaccine than family medicine residents and GP with mean(SD) of 4.19(1.27), 4.71(1.40), 3.81(1.45) and 3.50(1.33) respectively. There was a significant correlation between level of knowledge with practice and attitude towards HPV vaccine ( p=0.001). Conclusion:Primary health care physicians working in PHC inAlAhasa ,Saudi Arabia have basic knowledge about HPV vaccine with a preference for consultants with a higher percentage, then specialists, and lastly residents.
THE DEVELOPMENT OF GLAMPING ACTIVITIES IN MALAYSIA BEFORE AND AFTER THE PANDEMIC PHASE
Authors:   Institute of Islam Hadhari, UniversitiKebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Ibrahim Azam Ahmad , Hafiz Safiai Mohd ,   Institute of Islam Hadhari, UniversitiKebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.,   Research Centre for Sharia, Faculty of Islamic Studies, UniversitiKebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
Published: August 2023

Beginning 2015, Tourism Malaysia introduced glamping activity as one of Malaysias new tourism products, but its development seems has been very slow. Theactivity which is usually expensive and luxurious, besides the lack of ideas in highlighting its uniqueness, makes glamping an activity that is considered for the elites only. Therefore, this study was conducted to discuss the development of astronomy-based glamping activities in Malaysia before and after the pandemic phase. This research is qualitative, using the approach of document analysis and observation regarding the topic under study. Results of the study found that glamping activities which are based on astronomy are seen to be gaining popularity among the people society after pandemic period compared to normal glamping activities. This can also be observed in the increase of venues that offer astronomy-based glamping services.Astronomy-based glamping activities are one of tourism products which is offered to those who are fond of something which is unique and intriguing on objects or phenomena of the universe. This shows that the opportunity and scope for the activity to be carried out are wide. Glamping activities based on astronomy are usually closely related to dark sky areas and heavenly object phenomena such as solar and lunar eclipses. Astronomy-based glamping activity in Malaysia is one of the new products that can be popularised as a tourist attraction, and this activity is also seen capable of contributing to a rise in the nations economy.
TECHNOLOGICAL ADVANCEMENT- A WAY TO DIGITAL TRANSFORMATION OF BUSINESS
Authors:   Research ScholarReg No: 5210/2023/UOKUniversity of Kerala., Dinsha Shaliya
Published: August 2023

Technology has been a driving force behind the rapid advancement of digital transformation.Technology had played a crucial role in shaping the digital landscape,from communicating and collaborating to conducting business and managing data.Digital transformation is the process of adopting next generation technologies, bringing cultural changes to improve the current state of an organization. New technologies lead to process improvements which leads to better products and services.Even though technology has evolved, improved and helped business in different way, it had certain challenges in the way of its effective implementation. This paper discusses both the opportunities and challenges in technology adoption.
KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDS NEEDLE STICK INJURY AMONG HEALTH CARE WORKERS IN A PRIVATE HOSPITAL-QUESTIONNAIRE BASED STUDY
Authors: S. Vanitha , H.S Thejaswini , M. Varalakshmi
Published: August 2023

Background : An occupational injury is loosely termed as needle stick injury(NSI) , though it included injury through needle or other sharps and splashes4.They constitute major source of blood borne pathogens especially HIV, HBV, HCV. The risk of transmission after NSI is highest for HBV (2-40%), followed by HCV (2.7-10%), least for HIV (0.3%) 5. Purpose 1. To assess the occurrence of NSI among different categories of HCWs 2. To study various factors responsible and the circumstances under which they occur 3. To prevent these through improvement in knowledge, attitude and practice. Methods: A cross-sectional, questionnaire-based study was conducted among health care workers (HCWs) in a Private Hospital (Shanthi hospital and research centre) in Bengaluru from Jan to March 2023. This study included all HCW (50), who come in contact with patients, thus exposed to sharps and other occupational hazards. Data collection was carried out using standardized questionnaire, created based on review of the literature Results: out of 50, 21 were males and 29 were female. Maximum were in the age group of 20-40 yrs. 50 % of the HCWs are nursing staff, followed by 20% doctors, 18% housekeeping, 12% technicians. Needle stick injury was seen in 10% of HCWs. Out of 5 HCWs, only one has sustained 2 NSIs, remaining 4 HCWs had NSI only once. It was common in nursing staff as they will be dealing with sharps frequently. Interpretation & Conclusion: NSI rate is relatively low in this study compared to many other studies, even HBV Vaccination rate is good in this study. To improve the knowledge, attitude and practice towards NSI repeated training with pre and post test questionnaire is very important. More knowledge is required regarding needleless safety devices.
APERT SYNDROME : A CASE REPORT
Authors:   MDS Professor and Head,Oral Medicine and Radiology, Government Dental College and Hospital, Aurangabad., S. Pagare Jaishri , Ankita Amar Goklani ,   MDS Post Graduate Student (III year), Oral Medicine and Radiology, Government Dental College and Hospital, Aurangabad., Moon Virangana ,   MDS Post Graduate Student (I year), Oral Medicine and Radiology, Government Dental College and Hospital, Aurangabad.
Published: August 2023

Apert syndrome (AS) is indeed a rare congenital disorder that falls under the category of acrocephalosyndactyly. It is characterized by several distinct features, including craniosynostosis (premature fusion of certain skull bones), midface hypoplasia (underdevelopment of the middle part of the face), and syndactyly (fusion) of the hands and feet.The syndrome is typically caused by mutations in the fibroblast growth factor receptor gene (FGFR2). These mutations are inherited in an autosomal dominant pattern, which means that an affected individual has a 50% chance of passing the syndrome on to their children.Diagnosing Apert syndrome can be challenging due to its rarity and similarities with other craniosynostosis syndromes. However, certain key features can help differentiate it from other conditions. These features include early fusion of the coronal suture , cranial base synostosis , and agenesis (absence) of the sagittal suture (the suture running along the top of the skull).The characteristic appearance and dental features of Apert syndrome include maxillary transverse and sagittal hypoplasia, dental crowding, a pseudo-cleft palate and skeletal and dental anterior open bite.Given the multiple phenotypic signs and complex nature of the syndrome, successful management of Apert syndrome requires a multidisciplinary team approach. This team typically includes professionals from various specialties such as dentistry, neurosurgery, plastic surgery, psychiatry, ophthalmology, perinatology, and genetics. Each specialist contributes their expertise to provide comprehensive care and support for individuals with Apert syndrome.
READABILITY LEVEL OF THE ARABIC LANGUAGE TEXTBOOK OF DIPLOMA TAHFIZ AL-QURAN & AL-QIRAAT DARUL QURAN JAKIM
Authors:   Language Teacher,Faculty of Languages and Linguistics, Universiti Malaya., Khairul Akhbar Jahiruddin Mohd , Ab. Halim Zulazhan ,   Associate Professor, Faculty of Languages and Communication, Universiti Sultan Zainal Abidin -UniSZA., Azwan Kamarudin Mohamad ,   Language Teacher, Faculty of Islamic Studies, UniversitiKebangsaan Malaysia.
Published: August 2023

Textbooks, or special reference books for language learning, are an important medium in language learning at IPTs in Malaysia. The level of language achievement among IPT students who are not native speakers of Arabic is still low due to various factors, including the ineffective content of textbooks. The evaluation of reading material takes into account many aspects, especially the level of readability. Readability is the level or ease of a material or reading text, while a quality textbook is a reading text that is easy to understand. This study evaluates the readability of Arabic texts among Diploma Tahfiz Al-Quran and Al-Qiraat Darul Quran students in Malaysia. A total of 300 students consists of students in semester 4 and students who have gone through semester 4. This study is to evaluate the level of readability of the textbooks they use through a level-Cloze Test, which will be the start of further study of the book. This readability study serves as a document that can help JAKIM, lecturers, syllabus drafters, textbook writers, and other parties involved. In order to achieve the objectives of this study, the Cloze Test was constructed from three Arabic texts found in Darul Quran Arabic textbooks. Through this test, students are tested to see the difference in scores obtained from the aspect of readability. The study data is analyzed quantitatively and descriptively. The results of the test conducted found that the mean score for the Cloze Test on the textbook was 88%, so this result proves that the level of readability of Darul Quran JAKIMs Arabic textbook is at frustration levelwhich means that the textbook is not suitable enoughfor the ability of students at the Diploma level in Darul Quran JAKIM, which is still at a low level that is less suitable for teaching and learning purposes. Therefore, the responsible parties, especially the drafters of the Darul Quran Arabic language curriculum, should take into account the level of readability of the text provided before it is used as student learning material in order to match the level of the students language skills.
SUSTAINABLE LEADERSHIP AND PERFORMANCE OF SMS BUSINESSES IN TANZANIAS ILALA DISTRICT: THE MEDIATING ROLE OF ORGANIZATIONAL LEARNING
Authors:   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China., Robert Paul Eric , Yang Li ,   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China., Abekah Osman Siddiq ,   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China., Akuful Michael ,   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China.
Published: August 2023

This study aimed to identify leadership practices that contribute to Ilala, Tanzanias SME success and sustainability. The study examined how sustainable leadership affected Tanzanias Ilala SMEs long-term performance. The study focuses on successful SME leaders in micro, small, medium, and large firms with one to 100 employees and 5 million to 800 million Tanzanian shillings in capital investment (Tshs). This study links variables using quantitative data. Validate the models accuracy. Using t-tests and path values, PLS validates hypotheses. We concluded from the data: Research shows that organizational learning affects SMEs long-term leadership. Sustainable leadership improved Tanzanias Ilala SMEs social performance. The research found that sustainable leadership helped SMEs in Tanzanias Ilala region. Organizational learning improves SMEs long-term social performance in Tanzanias Ilala. According to research, sustainable leadership does not affect economic success. Sustainable leadership seems to indirectly promote sustainable economic success. Organizational learning moderates sustainable leadership and environmental performance. Organizational learning (OL) alters the link between sustainable leadership (SL) and sustainable social performance (SSP). Organizational learning (SECP) moderates sustainable leadership and economic performance. The government may promote leadership development. Training and mentoring can make SMEs more productive and sustainable.
EXPLORING NOTE TAKING HABITS AMONG EMERGENCY MEDICINE BOARD TRAINEES, AND ITS IMPLICATION ON LEARNING IN MEDICAL EDUCATION
Authors:   KFMC, Emergency Department., Eskandarani Dr. Rawan , Alahamdi Dr. Zainab ,   KFMC, Emergency Department., Alabdaljabbar Dr. Safa ,   KFMC, Emergency Department., Alhamad Dr. Abdulaziz ,   KFMC, Emergency Department.
Published: August 2023

This study investigates the impact of note-taking on academic performance and clinical practice among emergency medicine trainees. It compares paper-based and digital note-taking methods and evaluates note-taking skills and organization. The study aims to determine the need for changes in learning methods during residency and introduce a strategic note-taking approach to trainees. The findings reveal the association between note-taking and focus, retention, ability to recall in the medical learning setting and clinical practice. Paper-based note-taking is perceived as more effective for information retrieval. The study highlights the need for incorporating note-taking instruction into the medical education curriculum and developing effective note-taking skills for medical trainees.
COMPARITIVE STUDY OF PANC-3 AND BEDSIDE INDEX FOR SEVERITY IN ACUTE PANCREATITIS (BISAP) SCORING SYSTEM TO IDENTIFY SEVERITY OF PANCREATITIS
Authors:   Senior Resident, Department of General Surgery, ESIC Medical College and Post Graduate Institute of Medical Science and Research, Rajajinagar, Bengaluru., I. Guttedar Karthik , V.P Balaji ,   Senior Resident, Department of General Surgery, ESIC Medical College and Post Graduate Institute of Medical Science and Research, Rajajinagar, Bengaluru., S.K Ramesh ,   Senior Resident, Department of General Surgery, ESIC Medical College and Post Graduate Institute of Medical Science and Research, Rajajinagar, Bengaluru., Kumar N.S Krishna ,   Senior Resident, Department of General Surgery, ESIC Medical College and Post Graduate Institute of Medical Science and Research, Rajajinagar, Bengaluru., Sharma Nitin ,   Senior Resident, Department of General Surgery, ESIC Medical College and Post Graduate Institute of Medical Science and Research, Rajajinagar, Bengaluru.
Published: August 2023

Background & Objectives: Objective of this study is to evaluate accuracy and predictability of PANC-3 over BISAP scoring system to predict severity in an attack of acute pancreatitis. Methods: A total of 160 cases were enrolled in the study and was conducted in Department of General Surgery, ESICMC & PGIMSR, Bangalore. All patients with clinical diagnosis of acute pancreatitis will be included in the study. It was a prospective study with study period of 18 months. Results: A total number of 160 patients were included in the study. Patients presenting with acute pancreatitis were maximum in age group of 31-40 years which included 60 patients (37.5). 153 (96%) patients were male and 4 percent (n=7) are female. Most common cause is alcohol- 124 (77.5%) patients. Next common cause is the gallstone 19 patients (11.9%). The most common chief complaint in our study was characteristic upper abdominal pain (100%) followed by vomiting (22.5%), fever (13.8%), jaundice (1.9%) and abdominal distension (1.3%). 91 patients were diagnosed to have mild acute pancreatitis, 37 patients with moderate acute pancreatitis and 32 patients with severe acute pancreatitis. All the 32 patients were correctly predicted by PANC-3 score. 11(6.9%) developed complications like pancreatic necrosis, pancreatic abscess, upper gastrointestinal bleeding, MODS, sepsis and death. 3 patients died due to complications associated with severe pancreatitis which accounts for 1.9%. Interpretation &Conclusion: Our study shows that PANC-3 can be used to predict the severity of pancreatitis as efficiently as BISAP scoring. It uses only 3 criteria which are easily done and available in even the basic health care setup. The interpretation of PANC-3 does not need expertise and can be applied at the time of admission which is an advantage when compared to classical scoring systems.
Análisis prospectivo y líneas estratégicas de acción para la producción agraria colombiana en un entorno pos-COVID-19
Authors: Montoya-Restrepo Luz Alexandra , Montoya-Restrepo Ivan Alonso , Bermeo- Giraldo Maria Camila , Leiva- Barón Fabio Rodrigo
Published: August 2023

El artículo desarrolla un análisis prospectivo exploratorio, orientado a la identificación de elementos de análisis, escenarios y líneas de acción estratégicas sobre la producción agraria colombiana en un entorno pos-COVID-19. El método empleado desarrolló revisión de literatura, análisis estructural para la identificación de escenarios y la enunciación de líneas de acción. Los hallazgos sugieren que la crisis de demanda es el elemento más influyente, y que posibles transformaciones del sector tendrían que pasar por cambios en el uso de los territorios agrarios, en la subordinación institucional y en una novedosa perspectiva de seguridad alimentaria.
Transversalidad, WhatsApp, smartphone y redes sociales en el trabajo, la socialización y la individualidad
Authors: Ruvalcaba Arredondo Leonel , Ríos Rodríguez Leticia del Carmen , Carmona Eduardo Alejandro , López González Aída Janet
Published: August 2023

Conocer el uso que los empleados públicos dan al WhatsApp, a las redes sociales y a los teléfonos inteligentes durante el horario laboral, es un tema que se debe abrir para generar la discusión sobre los efectos que tienen estas herramientas tecnológicas en el interior de las alcaldías. El objetivo del presente trabajo es determinar un modelo que brinde información sobre el uso que hace de la aplicación WhatsApp, de las redes sociales y de los teléfonos inteligentes el personal administrativo de la alcaldía de Manizales, Colombia durante su jornada de trabajo. Se aplicó un instrumento compuesto por 15 preguntas a 164 trabajadores que laboran en esta oficina de servicio público, con respecto al uso masivo de estas tecnologías. Para observar cómo se conjuntan las variables se realizó un Análisis Factorial Exploratorio y para corroborar la contingencia entre los factores se llevó a cabo un Análisis Factorial Confirmatorio por medio de ecuaciones estructurales.
El juego como escenario de construcción de paz en contextos de conflicto armado en Colombia
Authors: Ramírez David Arturo Ospina , Ospina Alvarado María Camila
Published: August 2023

Introducción: el artículo presenta algunos resultados de una investigación que buscó rescatar y visibilizar las potencias y los recursos de la niñez que se vio afectada por el conflicto armado, preguntando por las maneras en que los niños y las niñas pueden aportar a la construcción de paz desde sus potencialidades y escenarios relacionales, dando prioridad al juego como espacio socializador. Método: la investigación fue de tipo cualitativa y se ubicó desde la hermenéutica crítica comprensiva, empleando estrategias metodológicas como talleres creativos, entrevistas a profundidad y grupos focales. Resultados: algunos de los resultados evidencian que los niños y las niñas aportan a la construcción de paz desde la creatividad, el establecimiento de acuerdos con sus pares y otros agentes, pero, sobre todo, desde el juego como principal escenario en donde despliegan su autonomía y criterio propio para la configuración de sus acuerdos sociales. Conclusión: se concluye que el juego se convierte en una práctica generativa, donde los niños y las niñas despliegan sus potencialidades y recursos como un aporte a la construcción paz.
Research trends on development of energy efficiency and renewable energy in households: A bibliometric analysis
Authors: Sotnyk Iryna , Kurbatova Tetiana , Trypolska Galyna , Sokhan Inna , Koshel Vsevolod
Published: August 2023

Households are responsible for more than one-third of global energy consumption and exert a significant environmental impact. Therefore, energy efficiency and renewable energy issues have been a top theme in the literature, with numerous studies examining different facets of residential power consumption, green energy transition, decarbonization, and energy conservation. Despite extensive attention, these research trends and frontiers remain largely uncharacterized and poorly understood. This study aims to provide clear insights into the evolution and latest trends of household energy efficiency and renewable energy studies, reveal significant contributing countries, institutions, and authors of published papers, as well as directions of international collaboration. The method of bibliometric analysis with two supporting instruments (the SciVal platform and Scopus “Analyze search results” tool) was used to investigate an array of 3,761 research items on renewable energy and 4,474 items on energy efficiency in homes formed from the Scopus database. The studied period includes papers published during 1978–2023. The systematic review indicated that the United States, the United Kingdom, and China are primarily contributing countries with strong international collaboration in this field. The top journals include Energy Policy, Energy Efficiency, Energies, and Sustainability, while highly cited researchers investigate environmental, economic, and social effects and management mechanisms for introducing innovative energy-efficient and renewable energy technologies in households like smart meters and grids or the Internet of Things. The research frontier might encompass emerging and pioneering studies on home decarbonization strategies, behavioral interventions, energy saving, prosumerism, and optimization of energy consumption.
AcknowledgmentThe paper is prepared within the framework of the research project “Formation of economic mechanisms to increase energy efficiency and provide sustainable development of renewable energy in Ukraine’s households” (No. 0122U001233), funded by the National Research Foundation of Ukraine.
Assessment of drought trends in the Upper Ewaso Ng'iro River Basin using the SPI and SPEI
Authors: Kimaiyo June Jerop , Mati Bancy Mbura , Sang Joseph Kipyegon , Kanda Edwin Kimutai
Published: August 2023

Drought assessment is necessary for creating adaptation and resilience measures for the livelihoods of the affected communities. This study assessed drought trends in Kenya's Upper Ewaso Ng'iro River Basin (UENB) from 1981 to 2020. A Standardized Precipitation Index (SPI), a precipitation-based index, and a Standardized Precipitation Evapotranspiration Index (SPEI), a multivariate index that considers the difference between precipitation and potential evapotranspiration (PET), were used to evaluate drought severity and frequency over varying timescales. Monthly rainfall and temperature data for 10 stations within the basin were analyzed to calculate the SPI and SPEI time series values for 3, 6, and 12 months. The results demonstrate an alarming increase in the severity and frequency of drought events in the UENB since 1999. Additionally, the study reveals that the SPI and SPEI indices differ in identifying temporal and spatial drought characteristics, with longer timescales showing improved accuracy. Notably, the SPEI identifies more extensive and severe drought periods in the region compared to the SPI. The research findings are crucial in guiding policy decisions related to SDGs as they provide valuable information on drought trends necessary for implementing effective drought adaptation and resilience measures and promoting sustainable development in the UENB.
Monthly streamflow forecasting for the Hunza River Basin using machine learning techniques
Authors: Khan Sunaid , Khan Mehran , Khan Afed Ullah , Khan Fayaz Ahmad , Khan Sohail , Fawad Muhammad
Published: August 2023

Streamflow forecasting is crucial for planning, designing, and managing water resources. Accurate streamflow forecasting is essential in developing water resource systems that are both technically and economically efficient. This study tested several machine learning techniques to estimate monthly streamflow data in the Hunza River Basin, Pakistan, using streamflow, precipitation, and air temperature data between 1985 and 2013. The techniques tested included adaptive boosting (AB), gradient boosting (GB), random forest (RF), and K-nearest neighbors (KNN). The models were developed using river discharge as the target variable, while air temperature and precipitation as the input variables. The model's performance was assessed via four statistical performance indicators namely root mean square error (RMSE), mean square error (MSE), mean absolute error (MAE), and coefficient of determination (R2). The results obtained for RMSE, MSE, MAE, and R2 using AB, GB, RF, and KNN techniques are (16.8, 281, 6.53, and 0.998), (95.1, 9,047, 61.5, and 0.921), (126.8, 16,078, 74.6, and 0.859), and (219.9, 48,356, 146.3, and 0.775), respectively. The results indicate that AB outperforms GB, RF, and KNN in predicting monthly streamflow for the Hunza River Basin. Machine learning, particularly AB, offers a reliable approach for streamflow forecasting, aiding hazard and water management in the area.
Groundwater quality assessment for sustainable irrigation in Nanton district, Ghana
Authors: Iddrisu Umar Farouk , Mbatchou Valentine Chi , Armah Edward Kwaku , Amedorme Bright Selorm
Published: August 2023

As part of the semi-arid region, Ghana falls within the West African Sahel region with high climatic variability and severe droughts, especially in the Northern parts. The Northern region is characterized as one of the driest in Ghana. It experiences one rainy season in a year, though agriculture is one of the main economic activities. Nanton district in the Northern region consists of farming communities. However, there is limited availability of water for crop watering during the dry season and groundwater could become a possible source of water supply. This research, therefore, seeks to provide information on the irrigation quality status of groundwater in the Nanton district. Information from this research also aims to assist policymakers take the right decisions for sustainable agriculture in the study area. Irrigation water indexes in combination with the USSL diagram were adopted as methods for analyses in this research. Results generally suggest that groundwater in the study area is suitable for irrigation purposes, except for a few places in the district. Further studies should be conducted to precisely state the quality of water used for drinking and domestic purposes. The research should also emphasize identifying factors controlling groundwater chemistry in the area.
Quantitative analysis of regional water resources and secure development of economic and social coupling systems
Authors: Zhen Jinghui , Nan Jianghao , Hou Jianghua
Published: August 2023

The development and rational utilization of regional water resources (RWR) is an important foundation for achieving comprehensive utilization of water resources and socio-economic progress. Socio-economic development has created necessary conditions and funds for the rational development of water resources, and the two support and constrain each other. Therefore, this article conducts a quantitative analysis of RWR to ensure the sustainable development of the economic and social (EAS) coupling system. An evaluation system was constructed based on feasibility analysis using the principal component analysis theory and entropy method. The results indicated that the interaction between RWR and EAS was relatively strong. In the seven-year survey, the coordinated development of the two showed an upward trend. The coupling and coordination indexes reached their lowest point in 2015 and have shown an upward trend. The coupling index increased by 0.34, and the coordination index increased by 0.21 to obtain a highly coordinated development state.
Structural and Functional Analysis of Urease Accessory Protein E from
Vancomycin-Resistance Staphylococcus aureus MU50 Strain
Authors: Siddiqui Humaira , Atia-tul-Wahab  , Ahmed Aftab , Choudhary M. Iqbal
Published: August 2023

Background:

An increasing prevalence of biofilm forming strains by vancomycinresistance
Staphylococcus aureus (VRSA) is one of the most important causes of antimicrobial
resistance. VRSA possesses various regulatory factors to form and sustain biofilm in biotic or abiotic
conditions. Among them, ureolytic activity is an important factor in the stabilization of biofilms by
neutralizing the acidic environment. Various urease accessory proteins are required to activate the
urease enzyme inside the biofilm.

Objective:

To optimize the cloning, expression and purification of urease accessory protein E from
VRSA for determination of the secondary structure, and functional characterization by using
Berthelot’s method.

Methods:

BAB58453.1 gene (which encodes possible urease accessory protein E), having 38%
similarity to Bacillus pasteurii UreE protein, was cloned, expressed, and purified by single-step
affinity chromatography for performing secondary structural studies using circular dichroism
spectroscopy, and functional analysis using Berthelot’s and crystal violet assay.

Results:

Structure elucidation using NMR and circular dichroism spectroscopy techniques revealed
that UreE protein has a partially foldedα-helical structure. Using Berthelot's method, it was identified
that the purified UreE protein has enhanced urease enzyme activity, in comparison to the control.
From the results of Berthelot’s and crystal violet assays, it was deduced that the selected gene (UreE
protein) plays a key role in enhancing urease enzyme activity and contributes to biofilm stability.

Conclusion:

Structural studies on VRSA urease accessory proteins could aid in the identification of
new drug targets or the development of effective antibiofilm strategies (in combination with other drug
targets) against infections caused by biofilm-producing strains.
In-situ Gels for Brain Delivery: Breaching the Barriers
Authors: Fatima Gul Naz , Maurya Priyanka , Nishtha  , Saraf Shailendra K.
Published: August 2023

The blood-brain barrier (BBB) regulates blood and chemical exchange in the central nervous system.
It is made up of brain parenchyma capillary endothelial cells. It separates the interstitial cerebrospinal fluid
from the circulation and limits brain drug entry. Peptides, antibodies, and even tiny hydrophilic biomolecules
cannot flow across the BBB due to their semi-permeability. It protects the brain from poisons, chemicals, and
pathogens, and blood cells penetrate brain tissue. BBB-facilitated carrier molecules allow selective permeability
of nutrients such as D-glucose, L-lactic acid, L-phenylalanine, L-arginine, and hormones, especially steroid
hormones. Brain barriers prevent drug molecules from entering, making medication delivery difficult. Drugs
can reach specific brain regions through the nasal cavity, making it a preferred route. The in-situ gels are mucoadhesive,
which extends their stay in the nasal cavity, allows them to penetrate deep and makes them a dependable
way of transporting numerous medications, including peptides and proteins, straight into the central
nervous system. This approach holds great potential for neurological therapy as they deliver drugs directly to
the central nervous system, with less interference and better drug release control. The brain affects daily life by
processing sensory stimuli, controlling movement and behaviour, and sustaining mental, emotional, and cognitive
functioning. Unlike systemic routes, the nasal mucosa is extensively vascularized and directly contacts olfactory
sensory neurons. Compared to the systemic circulation, this improves brain bioavailability of medications.
Drugs can be delivered to the brain using in-situ gel formulations safely and efficiently, with a greater
therapeutic impact than with traditional techniques.
Hesperidin Alleviates Acute Necrotizing Pancreatitis by Activating SIRT1
- Molecular Docking, Molecular Dynamics Simulation, and Experimental
Validation
Authors: Zhang Rui , Lan Junjie , Chen Qi , Liu Yang , Hu Linfang , Cao Jinyong , Zhao Huaye , Shen Yan
Published: August 2023

Background:

Acute necrotizing pancreatitis is a serious pancreatic injury with limited
effective treatments. This study aims to investigate the therapeutic effects of hesperidin on Larginine-
induced acute pancreatitis and its potential targets.

Methods:

The authors induced acute pancreatitis in mice by administering two hourly intraperitoneal
injections of L-arginine-HCl, and evaluated the impact of hesperidin on pancreatic and lung
tissues, plasma amylase activity, and myeloperoxidase content. Additionally, necrosis and mitochondrial
function was tested in primary pancreatic acinar cells. The interactions between hesperidin
and proteins involved in necrosis and mitochondrial dysfunction were further invested using in
silico molecular docking and molecular dynamic simulations.

Results:

Hesperidin effectively ameliorated the severity of acute necrotizing pancreatitis by reducing
plasma amylase, pancreatic MPO, serum IL-6 levels, pancreatic edema, inflammation, and
pancreatic necrosis. Hesperidin also protected against acute pancreatitis-associated lung injury and
prevented acinar cell necrosis, mitochondrial membrane potential loss, and ATP depletion. In addition,
hesperidin exhibited a high binding affinity with SIRT1 and increased the protein levels of
SIRT1. The SIRT1 inhibitor EX527 abolished the protective effect of hesperidin against necrosis
in acinar cells.

Conclusion:

These findings indicate that hesperidin alleviates the severity of acute necrotizing
pancreatitis by activating SIRT1, which may provide insight into the mechanisms of natural compounds
in treating AP. Hesperidin has potential as a therapeutic agent for acute necrotizing pancreatitis
and provides a new approach for novel therapeutic strategies.
Application of Thermoresponsive Smart Polymers based in situ Gel as a
Novel Carrier for Tumor Targeting
Authors: Sudhir Dhote Nidhi , Dineshbhai Patel Rajat , Kuwar Utkarsha , Agrawal Mukta , Alexander Amit , Jain Parag , Ajazuddin
Published: August 2023

The temperature-triggered in situ gelling system has been revolutionized by introducing
an intelligent polymeric system. Temperature-triggered polymer solutions are initially in a sol state
and then undergo a phase transition to form a gel at body temperature due to various parameters
like pH, temperature, and so on. These smart polymers offer a number of advantages, including
ease of administration, long duration of release of the drug, low administration frequency with
good patient compliance, and targeted drug delivery with fewer adverse effects. Polymers such as
poly(N-isopropylacrylamide) (PNIPAAm), polyethylene glycol (PEG), poly (N, N′-diethyl acrylamide),
and polyoxypropylene (PPO) have been briefly discussed. In addition to various novel
Drug Delivery Systems (DDS), the smart temperature-triggered polymeric system has various applications
in cancer therapy and many other disease conditions. This review focuses on the principals
involved in situ gelling systems using various temperature-triggered polymers for chemotherapeutic
purposes, using smart DDS, and their advanced application in cancer therapy, as well as available
marketed formulations and recent advances in these thermoresponsive sol-gel transforming
systems.
WITHDRAWN: Study of Different Types of Fermentation in Wine-making Process and Considering Aromatic Substances and Organic Acid
Authors: Shahrajabian Mohamad Hesam , Sun Wenli
Published: August 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the journal Current Organic Synthesis.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultane-ously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Exploring the Therapeutic Potential of Chrysanthemum morifolium:
An Ethnopharmacological Perspective
Authors: Ojha Smriti , Vishwakarma Pratik Kumar , Tripathi Shivendra Mani , Mishra Sudhanshu
Published: August 2023

Aim:

The current manuscript aims to discuss the ethnopharmacological relevance of the
common plant Chrysanthemum morifolium, also known as pot mums and its potential therapeutic
applications.

Methods:

A bibliography survey was carried out using various electronic databases like google
scholar, ScienceDirect, Springer, Scopus, PubMed, Wiley, etc. Other offline, as well as, online academic
libraries were also used for the bibliography survey and compilation of data.

Result and Discussion:

Traditional remedies have grown in both therapeutic and economic importance
around the world and are used by various groups of people. While the use of these medications
has grown, there are still concerns about their consistency, safety, and efficacy in many areas.
Chrysanthemum is the peak three of the world’s mainly significant cut flowers with an important
herb of traditional Chinese medicine (TCM). It contains abundant volatile oil and flavonoids. It has
been used for a long time to treat allergies, cardiovascular disease, severe flu, hypertension, and
sore throat. It also has characteristics such as anti-inflammatory, antibacterial, aromatic, demulcent,
febrifuge, hepatic, hypotensive, refrigerant, etc.

Conclusion:

It can be established from the complete study that various active constituents can be
isolated from the plant which has potential therapeutic value and justifies its use on modern scientific
parameters.
Interpretation and Classification of Phonocardiogram Using Principal
Component Analysis
Authors: Jatia Nikita , Kumar Sachin , Veer Karan
Published: August 2023

Background:

Large datasets are logically common yet frequently difficult to interpret.
Principal Component Analysis (PCA) is a technique to reduce the dimensionality of a dataset.

Objective:

The main objective of this work is to use principal component analysis to interpret and
classify phonocardiogram signals.

Methods:

Finding new factors aids in the reduction of important components of an eigenvalue/
eigenvector problem, thus enabling the new factors to be represented by the current dataset and
making PCA a flexible data analysis tool. PCA is adaptable to a variety of systems created to update
different data types and technology advancements.

Results:

Signals acquired from a patient, i.e., bio-signals, are used to investigate the patient's
strength. One such bio-signal of central significance is the phonocardiogram (PCG), which addresses
the working of the heart. Any change in the PCG signal is a characteristic proportion of
heart failure, an arrhythmia condition.

Conclusion:

Long-term observation is difficult due to the many complexities, such as the lack of
human competence and the high chance of misdiagnosis.