bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis
Authors: Ganesan Selvaganapathy , Ramajayam Kalaipriya , Kokulnathan Thangavelu , Palaniappan Arunkumar
Published: June 2023

Sweat, a biofluid secreted naturally from the eccrine glands of the human body, is rich in several electrolytes, metabolites, biomolecules, and even xenobiotics that enter the body through other means. Recent studies indicate a high correlation between the analytes’ concentrations in the sweat and the blood, opening up sweat as a medium for disease diagnosis and other general health monitoring applications. However, low concentration of analytes in sweat is a significant limitation, requiring high-performing sensors for this application. Electrochemical sensors, due to their high sensitivity, low cost, and miniaturization, play a crucial role in realizing the potential of sweat as a key sensing medium. MXenes, recently developed anisotropic two-dimensional atomic-layered nanomaterials composed of early transition metal carbides or nitrides, are currently being explored as a material of choice for electrochemical sensors. Their large surface area, tunable electrical properties, excellent mechanical strength, good dispersibility, and biocompatibility make them attractive for bio-electrochemical sensing platforms. This review presents the recent progress made in MXene-based bio-electrochemical sensors such as wearable, implantable, and microfluidic sensors and their applications in disease diagnosis and developing point-of-care sensing platforms. Finally, the paper discusses the challenges and limitations of MXenes as a material of choice in bio-electrochemical sensors and future perspectives on this exciting material for sweat-sensing applications.
β-CD-Induced Precipitation of Eriochrome Black T Recovered via CTAB-Assisted Foam Fractionation for Adsorption of Trace Cu(II)
Authors: Chang Yunkang , Cao Chengsong , Li Yuhuan , Yin Yitong , Liu Yangjing , Li Rui , Zhu Yimin
Published: June 2023

In order to remove and reuse the ecotoxic dye Eriochrome black T (EBT) from dyeing wastewater, we used a process called cetyltrimethylammonium bromide (CTAB)-assisted foam fractionation. By optimizing this process with response surface methodology, we achieved an enrichment ratio of 110.3 ± 3.8 and a recovery rate of 99.1 ± 0.3%. Next, we prepared composite particles by adding β-cyclodextrin (β-CD) to the foamate obtained through foam fractionation. These particles had an average diameter of 80.9 μm, an irregular shape, and a specific surface area of 0.15 m2/g. Using these β-CD-CTAB-EBT particles, we were able to effectively remove trace amounts of Cu2+ ions (4 mg/L) from the wastewater. The adsorption of these ions followed pseudo-second-order kinetics and Langmuir isotherm models, and the maximal adsorption capacities at different temperatures were 141.4 mg/g at 298.15 K, 143.1 mg/g at 308.15 K, and 144.5 mg/g at 318.15 K. Thermodynamic analysis showed that the mechanism of Cu2+ removal via β-CD-CTAB-EBT was spontaneous and endothermic physisorption. Under the optimized conditions, we achieved a removal ratio of 95.3 ± 3.0% for Cu2+ ions, and the adsorption capacity remained at 78.3% after four reuse cycles. Overall, these results demonstrate the potential of β-CD-CTAB-EBT particles for the recovery and reuse of EBT in dyeing wastewater.
Grafting of Crown Ether and Cryptand Macrocycles on Large Pore Stellate Mesoporous Silica for Sodium Cation Extraction
Authors: Duenas-Ramirez Paula , Bertagnolli Caroline , Weiss Robin , Bizeau Joëlle , Jierry Loïc , Choquet Philippe , Zaloszyc Ariane , Bégin-Colin Sylvie , Mertz Damien
Published: June 2023

Regulation of the sodium cations level in the case of renal failure diseases is a very challenging task for clinicians, and new pollutant extractors based on nanomaterials are emerging as potential treatments. In this work, we report different strategies for the chemical functionalization of biocompatible large pore mesoporous silica, denoted stellate mesoporous silica (STMS), with chelating ligands able to selectively capture sodium. We address efficient methods to covalently graft highly chelating macrocycles onto STMS NPs such as crown ethers (CE) and cryptands (C221) through complementary carbodiimidation reactions. Regarding sodium capture in water, C221 cryptand-grafted STMS showed better capture efficiency than CE-STMS due to higher sodium atom chelation in the cryptand cage (Na+ coverage of 15.5% vs. 3.7%). The sodium selectivity was hence tested with C221 cryptand-grafted STMS in a multi-element aqueous solution (metallic cations with the same concentration) and in a solution mimicking peritoneal dialysis solution. Results obtained indicate that C221 cryptand-grafted STMS are relevant nanomaterials to extract sodium cations in such media and allow us to regulate their levels.
Sensitive and Label-Free Colorimetric Detection of Glyphosate Based on the Suppression Peroxidase-Mimicking Activity of Cu(II) Ions
Authors: Li Qing , Guo Yumeng , He Xiangyi , Li Guangli
Published: June 2023

The sensitive and accurate determination of glyphosate (Glyp) is urgently demanded because it is closely correlated with human health and environmental safety. In this work, we proposed a sensitive and convenient colorimetric assay by employing copper ion peroxidases for the detection of Glyp in the environment. Free Cu(II) ions displayed high peroxidase activity and can catalytically oxidize the colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into blue oxTMB, resulting in an obviously visible discoloration reaction. Once the Glyp is added, the ability of copper ions to mimic peroxidase can be largely suppressed because of the generation of Glyp–Cu2+ chelate. The favorable selectivity and sensitivity were demonstrated in the colorimetric analysis of Glyp. Furthermore, this rapid and sensitive method was successfully applied in the accurate and reliable determination of glyphosate in the real sample, holding promising applications in pesticide determination in the environment.
On the Effectiveness of Using Virtual Reality to View BIM Metadata in Architectural Design Reviews for Healthcare
Authors: Buchanan Emma , Loporcaro Giuseppe , Lukosch Stephan
Published: June 2023

This article reports on a study that assessed whether Virtual Reality (VR) can be used to display Building Information Modelling (BIM) metadata alongside spatial data in a virtual environment, and by doing so determine if it increases the effectiveness of the design review by improving participants’ understanding of the design. Previous research has illustrated the potential for VR to enhance design reviews, especially the ability to convey spatial information, but there has been limited research into how VR can convey additional BIM metadata. A user study with 17 healthcare professionals assessed participants’ performances and preferences for completing design reviews in VR or using a traditional design review system of PDF drawings and a 3D model. The VR condition had a higher task completion rate, a higher SUS score and generally faster completion times. VR increases the effectiveness of a design review conducted by healthcare professionals.
Small Nucleolar (Sno)RNA: Therapy Lays in Translation
Authors: Rabany Ofri , Nachmani Daphna
Published: June 2023

The ribosome is one of the largest complexes in the cell. Adding to its complexity are more than 200 RNA modification sites present on ribosomal RNAs (rRNAs) in a single human ribosome. These modifications occur in functionally important regions of the rRNA molecule, and they are vital for ribosome function and proper gene expression. Until recent technological advancements, the study of rRNA modifications and their profiles has been extremely laborious, leaving many questions unanswered. Small nucleolar RNAs (snoRNAs) are non-coding RNAs that facilitate and dictate the specificity of rRNA modification deposition, making them an attractive target for ribosome modulation. Here, we propose that through the mapping of rRNA modification profiles, we can identify cell-specific modifications with high therapeutic potential. We also describe the challenges of achieving the targeting specificity needed to implement snoRNAs as therapeutic targets in cancers.
Ultrastructural Alterations of the Human Pathogen Giardia intestinalis after Drug Treatment
Authors: Benchimol Marlene , Gadelha Ana Paula , de Souza Wanderley
Published: June 2023

This review presents the main cell characteristics altered after in vitro incubation of the parasite with commercial drugs used to treat the disease caused by Giardia intestinalis. This important intestinal parasite primarily causes diarrhea in children. Metronidazole and albendazole are the primary compounds used in therapy against Giardia intestinalis. However, they provoke significant side effects, and some strains have developed resistance to metronidazole. Benzimidazole carbamates, such as albendazole and mebendazole, have shown the best activity against Giardia. Despite their in vitro efficacy, clinical treatment with benzimidazoles has yielded conflicting results, demonstrating lower cure rates. Recently, nitazoxanide has been suggested as an alternative to these drugs. Therefore, to enhance the quality of chemotherapy against this parasite, it is important to invest in developing other compounds that can interfere with key steps of metabolic pathways or cell structures and organelles. For example, Giardia exhibits a unique cell structure called the ventral disc, which is crucial for host adhesion and pathogenicity. Thus, drugs that can disrupt the adhesion process hold promise for future therapy against Giardia. Additionally, this review discusses new drugs and strategies that can be employed, as well as suggestions for developing novel drugs to control the infection caused by this parasite.
Prevalence of Latent Equid Herpesvirus Type 1 in Submandibular Lymph Nodes of Horses in Virginia
Authors: Saklou Nadia , Pleasant Scott , Lahmers Kevin , Funk Rebecca
Published: June 2023

Equine Herpesvirus type 1 (EHV-1) typically causes mild respiratory disease, but it can also cause late-term abortion, neonatal foal death and neurologic disease. Once a horse is infected, the virus concentrates to local lymphoid tissue, where it becomes latent. The virus can be reactivated during times of stress, which can lead to the initiation of devastating outbreaks. Understanding the carriage rate of latent EHV-1 in different geographic regions is essential for managing the disease. The objective of the current study was to estimate the prevalence of latent EHV-1 and compare the frequency of each variant in the submandibular lymph nodes of horses in Virginia. Sixty-three submandibular lymph nodes were collected post-partem from horses submitted to regional labs for necropsy, and qPCR was performed. All samples were negative for the gB gene of EHV-1. The results demonstrated a low apparent prevalence of latent EHV-1 DNA in submandibular lymph nodes in this population of horses in Virginia. Despite this, the mainstay for outbreak prevention and mitigation continues to focus on minimizing risks and using appropriate and diligent biosecurity.
“Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review
Authors: Desai Nimeet , Rana Dhwani , Pande Shreya , Salave Sagar , Giri Jyotsnendu , Benival Derajram , Kommineni Nagavendra
Published: June 2023

Achieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated nanosystems have emerged as a promising approach, providing a versatile platform for the development of next-generation smart nanosystems. This review article presents an in-depth investigation into the potential of these nanosystems for targeted cancer theranostics, encompassing key aspects such as cell membrane sources, isolation techniques, nanoparticle core selection, approaches for coating nanoparticle cores with the cell membrane, and characterization methods. Moreover, this review underscores strategies employed to enhance the multi-functionality of these nanosystems, including lipid insertion, membrane hybridization, metabolic engineering, and genetic modification. Additionally, the applications of these bioinspired nanosystems in cancer diagnosis and therapeutics are discussed, along with the recent advances in this field. Through a comprehensive exploration of membrane-coated nanosystems, this review provides valuable insights into their potential for precise cancer theranostics.
Pharmacokinetics of Venetoclax Co-Administered with Posaconazole in Patients with Acute Myeloid Leukemia
Authors: De Gregori Simona , Gelli Eleonora , Capone Mara , Gambini Giulia , Roncoroni Elisa , Rossi Marianna , Tobar Cabrera Claudia Patricia , Martini Gianluca , Calabretta Ludovica , Arcaini Luca , Albertini Riccardo , Zappasodi Patrizia
Published: June 2023

The Food and Drug Administration currently approves the combination of hypomethylating agents (HMA), azacytidine or decitabine with venetoclax (VEN) for acute myeloid leukemia (AML) patients aged more than 75 years and for patients unsuitable for intensive chemotherapy. The risk of fungal infection in the early phase of treatment is not negligible; therefore, posaconazole (PCZ) is commonly administered as primary prophylaxis. A drug–drug interaction between VEN and PCZ is well known, but the trend of serum levels of venetoclax when both drugs are overlapped is not clear. In total, 165 plasma samples from 11 elderly AML patients receiving combined treatment with HMA, VEN and PCZ were analyzed by a validated analytical method (high-pressure liquid chromatography–tandem mass spectrometry). Venetoclax trough plasma concentrations were detected during the 3 days of ramp-up as well as on day 7 and day 12 of treatment when the exposure as the area under the plasma concentration–time curve and the accumulation ratio were also calculated. The results were compared with the expected data for 400 mg/dose VEN administered alone—the confirmed high inter-individual variability in pharmacokinetics suggests the need for therapeutic drug monitoring.
Modification of the Emission Spectrum of a Quantum Emitter in the Vicinity of Bismuth Chalcogenide Microparticles
Authors: Papadaki Margarita-Georgia , Kyvelos Nikolaos , Paspalakis Emmanuel , Yannopapas Vassilios
Published: June 2023

We examine theoretically the effect of bismuth chalcogenide microparticles on the spontaneous emission of a double-V-type quantum emitter in free space. We have found, in particular, that the presence of a single microparticle causes a high degree of quantum interference in the way the quantum emitter releases energy in the process of spontaneous emission. This, in turn, leads to significant changes in the spectrum of the emitted energy. The quantum emitter’s initial state is crucial to how the energy is released in the presence of the microparticle. This observation has potential implications for quantum computing, particularly for reading the state of atomic qubits. When two microparticles are present, the effect is more pronounced, particularly when the quantum emitter is located in the gap between the particles.
Generation of Photon Orbital Angular Momentum and Its Application in Space Division Multiplexing
Authors: Olaleye Temitope M. , Ribeiro Paulo A. , Raposo Maria
Published: June 2023

In the last three decades, light’s orbital angular momentum (OAM) has been of great interest because it has unique characteristics that make it sought after in many research fields, especially in optical communications. To address the exponentially increasing demands for higher data rates and capacity in optical communication systems, OAM has emerged as an additional degree of freedom for multiplexing and transmitting multiple independent data streams within a single spatial mode using the spatial division multiplexing (SDM) technology. Innumerable research findings have proven to scale up the channel capacity of communication links by a very high order of magnitude, allowing it to circumvent the reaching of optical fiber’s non-linear Shannon limit. This review paper provides a background and overview of OAM beams, covering the fundamental concepts, the various OAM generators, and the recent experimental and commercial applications of the OAM-SDM multiplexing technique in optical communications.
Periodical Progress in Ecophysiology and Ecology of Grassland
Authors: Xu Bingcheng , Wen Zhongming
Published: June 2023

As one of the most important ecosystems on the planet, grasslands serve a variety of purposes in ecology, economy, culture and entertainment [...]
Histological and Physiological Effects of Treatment of Rudbeckia hirta with Gamma Radiation
Authors: Kisvarga Szilvia , Hamar-Farkas Dóra , Horotán Katalin , Solti Ádám , Simon Edina , Ördögh Máté , Neményi András , Boronkay Gábor , Orlóci László
Published: June 2023

The breeding of resistant, high-yield, decorative ornamental plant varieties may be impacted by climate change in the future. The use of radiation induces mutations in plants, thereby increasing the genetic variability of plant species. Rudbeckia hirta has long been a very popular species in urban green space management. The goal is to examine whether gamma mutation breeding can be applied to the breeding stock. Specifically, differences were measured between the M1 and M2 generations, as well as the effect of different radiation doses belonging to the same generation. Morphological measurements showed that gamma radiation has an effect on the measured parameters in several cases (larger crop size, faster development, larger number of trichomes). Physiological measurements (examination of chlorophyll and carotenoid content, POD activity, and APTI) also showed a beneficial effect of radiation, especially at higher doses (30 Gy), for both tested generations. The treatment was also effective in the case of 45 Gy, but this radiation dose resulted in lower physiological data. The measurements show that gamma radiation has an effect on the Rudbeckia hirta strain and may play a role in breeding in the future.
Development of Light-Polymerized Dental Composite Resin Reinforced with Electrospun Polyamide Layers
Authors: Maletin Aleksandra , Ristić Ivan , Nešić Aleksandra , Knežević Milica Jeremić , Koprivica Daniela Đurović , Cakić Suzana , Ilić Dušica , Milekić Bojana , Puškar Tatjana , Pilić Branka
Published: June 2023

As the mechanical properties of resin-based dental composite materials are highly relevant in clinical practice, diverse strategies for their potential enhancement have been proposed in the extant literature, aiming to facilitate their reliable use in dental medicine. In this context, the focus is primarily given to the mechanical properties with the greatest influence on clinical success, i.e., the longevity of the filling in the patient’s mouth and its ability to withstand very strong masticatory forces. Guided by these objectives, the goal of the present study was to ascertain whether the reinforcement of dental composite resins with electrospun polyamide (PA) nanofibers would improve the mechanical strength of dental restoration materials. For this purpose, light-cure dental composite resins were interspersed with one and two layers comprising PA nanofibers in order to investigate the influence of such reinforcement on the mechanical properties of the resulting hybrid resins. One set of the obtained samples was investigated as prepared, while another set was immersed in artificial saliva for 14 days and was subsequently subjected to the same set of analyses, namely Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). Findings yielded by the FTIR analysis confirmed the structure of the produced dental composite resin material. They also provided evidence that, while the presence of PA nanofibers did not influence the curing process, it strengthened the dental composite resin. Moreover, flexural strength measurements revealed that the inclusion of a 16 μm-thick PA nanolayer enabled the dental composite resin to withstand a load of 3.2 MPa. These findings were supported by the SEM results, which further indicated that immersing the resin in saline solution resulted in a more compact composite material structure. Finally, DSC results indicated that as-prepared as well as saline-treated reinforced samples had a lower glass transition temperature (Tg) compared to pure resin. Specifically, while pure resin had a Tg of 61.6 °C, each additional PA nanolayer decreased the Tg by about 2 °C, while the further reduction was obtained when samples were immersed in saline for 14 days. These results show that electrospinning is a facile method for producing different nanofibers that can be incorporated into resin-based dental composite materials to modify their mechanical properties. Moreover, while their inclusion strengthens the resin-based dental composite materials, it does not affect the course and outcome of the polymerization reaction, which is an important factor for their use in clinical practice.
Biomaterials as Implants in the Orthopedic Field for Regenerative Medicine: Metal versus Synthetic Polymers
Authors: Al-Shalawi Faisal Dakhelallah , Mohamed Ariff Azmah Hanim , Jung Dong-Won , Mohd Ariffin Mohd Khairol Anuar , Seng Kim Collin Looi , Brabazon Dermot , Al-Osaimi Maha Obaid
Published: June 2023

Patients suffering bone fractures in different parts of the body require implants that will enable similar function to that of the natural bone that they are replacing. Joint diseases (rheumatoid arthritis and osteoarthritis) also require surgical intervention with implants such as hip and knee joint replacement. Biomaterial implants are utilized to fix fractures or replace parts of the body. For the majority of these implant cases, either metal or polymer biomaterials are chosen in order to have a similar functional capacity to the original bone material. The biomaterials that are employed most often for implants of bone fracture are metals such as stainless steel and titanium, and polymers such as polyethene and polyetheretherketone (PEEK). This review compared metallic and synthetic polymer implant biomaterials that can be employed to secure load-bearing bone fractures due to their ability to withstand the mechanical stresses and strains of the body, with a focus on their classification, properties, and application.
Developing Transparent and Conductive PolyHEMA Gels Using Deep Eutectic Solvents
Authors: Chen Tai-Yu , Jiang Yi-Jie , Chien Hsiu-Wen
Published: June 2023

Poly(2-hydroxyethyl methacrylate) (polyHEMA) hydrogels are commonly used in biomaterials such as contact lenses. However, water evaporation from these hydrogels can cause discomfort to wearers, and the bulk polymerization method used to synthesize them often results in heterogeneous microstructures, reducing their optical properties and elasticity. In this study, we synthesized polyHEMA gels using a deep eutectic solvent (DES) instead of water and compared their properties to traditional hydrogels. Fourier-transform infrared spectroscopy (FTIR) showed that HEMA conversion in DES was faster than in water. DES gels also demonstrated higher transparency, toughness, and conductivity, along with lower dehydration, than hydrogels. The compressive and tensile modulus values of DES gels increased with HEMA concentration. A DES gel with 45% HEMA showed excellent compression–relaxation cycles and had the highest strain at break value in the tensile test. Our findings suggest that DES is a promising alternative to water for synthesizing contact lenses with improved optical and mechanical properties. Furthermore, DES gels’ conduction properties may enable their application in biosensors. This study presents an innovative approach to synthesizing polyHEMA gels and provides insights into their potential applications in the biomaterials field.
Dendrimer-Based Coatings on a Photonic Crystal Surface for Ultra-Sensitive Small Molecule Detection
Authors: Shakurov Ruslan , Sizova Svetlana , Dudik Stepan , Serkina Anna , Bazhutov Mark , Stanaityte Viktorija , Tulyagin Petr , Konopsky Valery , Alieva Elena , Sekatskii Sergey , Bespyatykh Julia , Basmanov Dmitry
Published: June 2023

We propose and demonstrate dendrimer-based coatings for a sensitive biochip surface that enhance the high-performance sorption of small molecules (i.e., biomolecules with low molecular weights) and the sensitivity of a label-free, real-time photonic crystal surface mode (PC SM) biosensor. Biomolecule sorption is detected by measuring changes in the parameters of optical modes on the surface of a photonic crystal (PC). We describe the step-by-step biochip fabrication process. Using oligonucleotides as small molecules and PC SM visualization in a microfluidic mode, we show that the PAMAM (poly-amidoamine)-modified chip’s sorption efficiency is almost 14 times higher than that of the planar aminosilane layer and 5 times higher than the 3D epoxy-dextran matrix. The results obtained demonstrate a promising direction for further development of the dendrimer-based PC SM sensor method as an advanced label-free microfluidic tool for detecting biomolecule interactions. Current label-free methods for small biomolecule detection, such as surface plasmon resonance (SPR), have a detection limit down to pM. In this work, we achieved for a PC SM biosensor a Limit of Quantitation of up to 70 fM, which is comparable with the best label-using methods without their inherent disadvantages, such as changes in molecular activity caused by labeling.
Smart Dental Materials Intelligently Responding to Oral pH to Combat Caries: A Literature Review
Authors: Yu Kan , Zhang Qinrou , Dai Zixiang , Zhu Minjia , Xiao Le , Zhao Zeqing , Bai Yuxing , Zhang Ke
Published: June 2023

Smart dental materials are designed to intelligently respond to physiological changes and local environmental stimuli to protect the teeth and promote oral health. Dental plaque, or biofilms, can substantially reduce the local pH, causing demineralization that can then progress to tooth caries. Progress has been made recently in developing smart dental materials that possess antibacterial and remineralizing capabilities in response to local oral pH in order to suppress caries, promote mineralization, and protect tooth structures. This article reviews cutting-edge research on smart dental materials, their novel microstructural and chemical designs, physical and biological properties, antibiofilm and remineralizing capabilities, and mechanisms of being smart to respond to pH. In addition, this article discusses exciting and new developments, methods to further improve the smart materials, and potential clinical applications.
Evaluation of Reconstruction Potential for Low-Production Vertical Wells of CBM in the Southern Qinshui Basin
Authors: Xue Kaihong , Sun Beilei , Liu Chao
Published: June 2023

Production practice has shown that not all low-production coalbed methane (CBM) wells can be reconstructed into high-production wells through secondary stimulation, so it is necessary and timely to establish an evaluation index system, form an evaluation method, and evaluate the reconstruction potential of low-production wells. Based on the development practice of CBM in the southern Qinshui Basin, this paper analyzes the influencing factors of low production in vertical wells from the aspects of coal and rock reservoir conditions, drilling and completion engineering, and drainage engineering. It is proposed that the evaluation of the reconstruction potential of low-production wells should focus on the quality of CBM resources, the difficulty of CBM desorption and diffusion, and the degree of damage to coal reservoirs caused by the initial reservoir stimulation. Twelve parameters, including gas content, gas saturation, reservoir pressure gradient, critical desorption–reservoir pressure ratio, and permeability, were systematically selected as evaluation indicators, and the grading reference values for each evaluation indicator were comparatively given. Then, a multi-factor comprehensive evaluation method for the reconstruction potential of low-production wells based on gray correlation analysis method was established. The reconstruction potential of low-production wells was divided into three levels: high, medium, and low. When reconstructing low-production wells, it is recommended to prioritize the low-production wells with high reconstruction potential, followed by those with medium reconstruction potential, while low-production wells with low reconstruction potential are not recommended for reconstruction. Finally, the evaluation method was used to evaluate the reconstruction potential of five low-production wells in a CBM block, and suggestions for the reconstruction order and reconstruction potential levels for each well were given.
Investigating the Performance and Stability of Fe3O4/Bi2MoO6/g-C3N4 Magnetic Photocatalysts for the Photodegradation of Sulfonamide Antibiotics under Visible Light Irradiation
Authors: Li Ke , Chen Miaomiao , Chen Lei , Xue Wencong , Pan Wenbo , Han Yanchao
Published: June 2023

In this study, an Fe3O4/Bi2MoO6/g-C3N4 magnetic composite photocatalyst was synthesized for the visible-light-driven photocatalytic degradation of sulfonamide antibiotics, specifically sulfamerazine (SM1). Characterization techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), photoluminescence spectroscopy (PL), UV-vis diffuse reflectance spectra (UV-vis), and the use of a vibrating sample magnetometer (VSM), were employed to analyze the fabricated samples. The composite exhibited efficient visible-light absorption and charge separation, with optimal photocatalytic performance achieved at a pH value of 9.0. The study reveals the importance of solution pH in the degradation process and the potential applicability of the composite for efficient magnetic separation and recycling in photocatalytic processes. The Fe3O4/Bi2MoO6/g-C3N4 magnetic composite photocatalyst demonstrated exceptional stability and recyclability, maintaining a high degradation efficiency of over 87% after five consecutive cycles. An XRD analysis conducted after the cycling tests confirmed that the composite’s composition and chemical structure remained unchanged, further supporting its chemical stability. This investigation offers valuable insights into the photocatalytic degradation of sulfonamide antibiotics using magnetic composite photocatalysts and highlights the potential of the Fe3O4/Bi2MoO6/g-C3N4 composite for practical applications in environmental remediation.
Human Dignity in Inpatient Care: Fragments of Religious and Social Grounds
Authors: Šip Maroš , Kuzyšin Bohuslav , Sabolik Miroslav , Valčo Michal
Published: June 2023

Background: Navigating inpatient care can be complex and distressing for patients, particularly as they grapple with the emotional and physical changes brought about by their condition. Ensuring the preservation of human dignity during this period is vital, as it directly influences an individual’s self-esteem and overall quality of life, most prominently during end-of-life care. The hospital milieu and the behaviour of healthcare professionals can significantly affect a patient’s dignity. This paper scrutinized the concept of human dignity in inpatient care, with a primary emphasis on its theological, social, and regional context, drawing particularly on the Eastern Orthodox tradition and the central European, specifically Slovakian, context. Methodology: This study engaged respected authors in theology, social science, and healthcare to present an enriched understanding of the bio-psycho-social-spiritual components of human dignity. The analysis incorporated a blend of theological concepts, empirical findings, and regional insights to provide a nuanced perspective on dignity conservation. Results: The study illuminates the criticality of preserving human dignity from a multi-dimensional perspective, promoting patient autonomy, acknowledging their cultural and spiritual beliefs, and confronting societal attitudes and practices. It draws from theological doctrines and the European Charter of Patient’s Rights to advocate for a nuanced, dignity-conserving approach to patient care. Case studies and practical strategies for preserving human dignity in palliative care contexts, based on clinical guidelines, empirical studies, and theological writings, are presented. Conclusions: This study highlights the integral role of human dignity from both theological and practical perspectives in inpatient care, advocating for a comprehensive, patient-centered approach to care that values the individual’s bio-psycho-social-spiritual facets. It underscores the necessity for a collaborative commitment between healthcare providers, patients, and their families to foster a milieu that unconditionally supports the dignity of the ill person.
A University-Church-Community Look at Community Health Using Community-Based-Participatory Research
Authors: Pfeiffer Jane , Baba Djara Monita , Gillespie Timothy
Published: June 2023

The purpose of this sequential explanatory mixed-method approach using quantitative methods followed by qualitative inquiry was to assess a Southern California community’s perception of its health and of barriers to improving health. The qualitative aspects of this mixed-method CBPR project by a church-university-community partnership further describe member perceptions of their community and contributors/barriers to community health. Four focus group interviews were conducted over eight months at two elementary schools with the mothers of school children (N = 21) in the 2017–2018 and 2018–2019 school years, including one Spanish-only group. Four themes emerged, describing the contributors and barriers to community health and well-being: lack of connection, poor communication, fear/anxiety, and lack of access to affordable healthcare. The findings highlight how small anchor institutions, those whose primary mission is not health (church, school, trailer park, local businesses, etc.), can be facilitators of health and address these disruptions of connectivity, communication, and care present within the healthcare system itself, and its disappointed community recipients of “care”. The church as a community of care, in collaboration with educational institutions, is suited to invite community participation, affirm humanness, build trust, and offer increased access to care in the neighborhoods surrounding its location.
Investigating Causes of Model Instability: Properties of the Prediction Accuracy Index
Authors: Taplin Ross
Published: June 2023

The Prediction Accuracy Index (PAI) monitors stability, defined as whether the predictive power of a model has deteriorated due to a change in the distribution of the explanatory variables since its development. This paper shows how the PAI is related to the Mahalanobis distance, an established statistic for examining high leverage observations in data. This relationship is used to explore properties of the PAI, including tools for how the PAI can be decomposed into effects due to (a) individual observations/cases, (b) individual variables, and (c) shifts in the mean of variables. Not only are these tools useful for practitioners to help determine why models fail stability, but they also have implications for auditors and regulators. In particular, reasons why models containing econometric variables may fail stability are explored and suggestions to improve model development are discussed.
Finger Joint Stiffness Estimation with Joint Modular Soft Actuators for Hand Telerehabilitation
Authors: Matsunaga Fuko , Kokubu Shota , Tortos Vinocour Pablo Enrique , Ke Ming-Ta , Hsueh Ya-Hsin , Huang Shao Ying , Gomez-Tames Jose , Yu Wenwei
Published: June 2023

In a telerehabilitation environment, it is difficult for a therapist to understand the condition of a patient’s finger joints because of the lack of direct assessment. In particular, not enabling the provision of spasticity evaluation significantly reduces the optimal performance of telerehabilitation. In a previous study, it has been proposed that finger stiffness could be estimated using an analytical model of a whole-finger soft actuator. However, because the whole-finger soft actuators require high air pressure for high bending performance and are costly to customize for each patient, using joint modular soft actuators for telerehabilitation turns to be a necessity, though stiffness estimation with joint modular soft actuators has not been studied yet. Another problem is caused by using a marker-based joint angle measurement, which requires the markers to be attached to the exact positions, and limits its application in telerehabilitation. In this study, we proposed a procedure of finger joint stiffness estimation that combines information acquired from a joint modular soft actuator and a marker-less hand joint position acquisition device. Correction parameters were added to the previous analytical model for -the bending analysis of a joint assisted using a joint modular soft actuator. Moreover, a multi-variate regression model was implemented for correcting joint angles obtained from the hand joint position acquisition device. As a result, a reasonable accuracy of stiffness estimation was achieved for rehabilitation with the joint modular soft actuators, which suggests the possibility of using the proposed method to evaluate the finger spasticity in a telerehabilitation environment. This is a big step forward towards optimal hand telerehabilitation.
Contemporaneous Thick- and Thin-Skinned Seismotectonics in the External Zagros: The Case of the 2021 Fin Doublet, Iran
Authors: Golshadi Zeinab , Famiglietti Nicola Angelo , Caputo Riccardo , SoltaniMoghadam Saeed , Karimzadeh Sadra , Memmolo Antonino , Falco Luigi , Vicari Annamaria
Published: June 2023

In this work, we propose a geodetic model for the seismic sequence, with doublet earthquakes, that occurred in Bandar Abbas, Iran, in November 2021. A dataset of Sentinel-1 images, processed using the InSAR (Interferometric Synthetic Aperture Radar) technique, was employed to identify the surface deformation caused by the major events of the sequence and to constrain their geometry and kinematics using seismological constraints. A Coulomb stress transfer analysis was also applied to investigate the sequence’s structural evolution in space and time. A linear inversion of the InSAR data provided a non-uniform distribution of slip over the fault planes. We also performed an accurate relocation of foreshocks and aftershocks recorded by locally established seismographs, thereby allowing us to determine the compressional tectonic stress regime affecting the crustal volume. Despite the very short time span of the sequence, our results clearly suggest that distinct blind structures that were previously unknown or only suspected were the causative faults. The first Mw 6.0 earthquake occurred on an NNE-dipping, intermediate-angle, reverse-oblique plane, while the Mw 6.4 earthquake occurred on almost horizontal or very low-angle (SSE-dipping) reverse segments with top-to-the-south kinematics. The former, which cut through and displaced the Pan-African pre-Palaeozoic basement, indicates a thick-skinned tectonic style, while the latter rupture(s), which occurred within the Palaeozoic–Cenozoic sedimentary succession and likely exploited the stratigraphic mechanical discontinuities, clearly depicts a thin-skinned style.
HF Radar Wind Direction: Multiannual Analysis Using Model and HF Network
Authors: Saviano Simona , Biancardi Anastasia Angela , Kokoszka Florian , Uttieri Marco , Zambianchi Enrico , Cusati Luis Alberto , Pedroncini Andrea , Cianelli Daniela
Published: June 2023

HF radar systems have the potential to measure the wind direction, in addition to surface currents and wave fields. However, studies on HF radar for wind direction determination are rare in the scientific literature. Starting with the results presented in Saviano et al. (2021), we here expand on the reliability of the multiannual wind direction data retrieved over two periods, from May 2008 to December 2010 and from January to December 2012, by a network of three SeaSonde high-frequency (HF) radars operating in the Gulf of Naples (Central Tyrrhenian Sea, Western Mediterranean Sea). This study focuses on the measurements obtained by each antenna over three range cells along a coast–offshore transect, pointing to any potential geographically dependent measurement. The scarcity of offshore wind measurements requires the use of model-generated data for comparative purposes. The data here used are obtained from the Mediterranean Wind–Wave Model, which provides indications for both wave and wind parameters, and the ERA5@2km wind dataset obtained by dynamically downscaling ERA5 reanalysis. These data are first compared with in situ data and subsequently with HF-retrieved wind direction measurements. The analysis of the overall performance of the HF radar network in the Gulf of Naples confirms that the HF radar wind data show the best agreement when the wind speed exceeds a 5 m/s threshold, ensuring a sufficiently energetic surface wave field to be measured. The results obtained in the study suggest the necessity of wind measurements in offshore areas to validate the HF radar wind measurements and to improve the extraction algorithms. The present work opens up further investigations on the applications of wind data from SeaSonde HF radars as potential monitoring platforms, both in coastal and offshore areas.
Applicability of the Meniscus-Removal Method for Q-Band Liquid Characterization in Semi-Open Waveguide Cell
Authors: Kalisiak Michał , Wiatr Wojciech , Papis Radosław
Published: June 2023

We present the broadband transmission-reflection meniscus-removal method for liquid characterization in a semi-open rectangular waveguide. The algorithm utilizes 2-port scattering parameters measured with a calibrated vector network analyzer for three states of the measurement cell: empty and filled with two liquid levels. The method enables the mathematical de-embedding of a symmetrical sample of a liquid, not distorted with a meniscus, and provision of its permittivity and permeability, as well as its height. We validate the method for propan-2-ol (IPA), a 50% aqueous solution of IPA, and distilled water in the Q-band (33–50 GHz). We investigate typical problems for in-waveguide measurements, such as phase ambiguity.
A Sparse Shared Aperture Design for Simultaneous Transmit and Receive Arrays with Beam Constraints
Authors: Hu Dujuan , Wei Xizhang , Xie Mingcong , Tang Yanqun
Published: June 2023

The utilization of efficient digital self-interference cancellation technology enables the simultaneous transmit and receive (STAR) phased array system to meet most application requirements through STAR capabilities. However, the development of application scenario requirements makes array configuration technology for STAR phased arrays increasingly important. Thus, this paper proposes a sparse shared aperture STAR reconfigurable phased array design based on beam constraints which are achieved by a genetic algorithm. Firstly, a design scheme for transmit and receive arrays with symmetrical shared apertures is adopted to improve the aperture efficiency of both transmit and receive arrays. Then, on the basis of shared aperture, sparse array design is introduced to further reduce system complexity and hardware costs. Finally, the shape of the transmit and receive arrays is determined by constraining the side lobe level (SLL), main lobe gain, and beam width. The simulated results indicate that the SLL of the transmit and receive patterns under beam-constrained design have been reduced by 4.1 dBi and 7.1 dBi, respectively. The cost of SLL improvement is a reduction in transmit gain, receive gain, and EII of 1.9 dBi, 2.1 dBi, and 3.9 dB, respectively. When the sparsity ratio is greater than 0.78, the SLL suppression effect is also significant, and the attenuation of EII, transmit, and receive gains do not exceed 3 dB and 2 dB, respectively. Overall, the results demonstrate the effectiveness of a sparse shared aperture design based on beam constraints in producing high gain, low SLL, and low-cost transmit and receive arrays.
Enhanced Deep Learning Model for Classification of Retinal Optical Coherence Tomography Images
Authors: Hassan Esraa , Elmougy Samir , Ibraheem Mai R. , Hossain M. Shamim , AlMutib Khalid , Ghoneim Ahmed , AlQahtani Salman A. , Talaat Fatma M.
Published: June 2023

Retinal optical coherence tomography (OCT) imaging is a valuable tool for assessing the condition of the back part of the eye. The condition has a great effect on the specificity of diagnosis, the monitoring of many physiological and pathological procedures, and the response and evaluation of therapeutic effectiveness in various fields of clinical practices, including primary eye diseases and systemic diseases such as diabetes. Therefore, precise diagnosis, classification, and automated image analysis models are crucial. In this paper, we propose an enhanced optical coherence tomography (EOCT) model to classify retinal OCT based on modified ResNet (50) and random forest algorithms, which are used in the proposed study’s training strategy to enhance performance. The Adam optimizer is applied during the training process to increase the efficiency of the ResNet (50) model compared with the common pre-trained models, such as spatial separable convolutions and visual geometry group (VGG) (16). The experimentation results show that the sensitivity, specificity, precision, negative predictive value, false discovery rate, false negative rate accuracy, and Matthew’s correlation coefficient are 0.9836, 0.9615, 0.9740, 0.9756, 0.0385, 0.0260, 0.0164, 0.9747, 0.9788, and 0.9474, respectively.
Brillouin-Scattering Induced Noise in DAS: A Case Study
Authors: Gorshkov Boris G. , Simikin Denis E. , Alekseev Alexey E. , Taranov Mikhail A. , Zhukov Konstantin M. , Potapov Vladimir T.
Published: June 2023

In the paper, the effect of spontaneous Brillouin scattering (SpBS) is analyzed as a noise source in distributed acoustic sensors (DAS). The intensity of the SpBS wave fluctuates over time, and these fluctuations increase the noise power in DAS. Based on experimental data, the probability density function (PDF) of the spectrally selected SpBS Stokes wave intensity is negative exponential, which corresponds to the known theoretical conception. Based on this statement, an estimation of the average noise power induced by the SpBS wave is given. This noise power equals the square of the average power of the SpBS Stokes wave, which in turn is approximately 18 dB lower than the Rayleigh backscattering power. The noise composition in DAS is determined for two configurations, the first for the initial backscattering spectrum and the second for the spectrum in which the SpBS Stokes and anti-Stokes waves are rejected. It is established that in the analyzed particular case, the SpBS noise power is dominant and exceeds the powers of the thermal, shot, and phase noises in DAS. Accordingly, by rejecting the SpBS waves at the photodetector input, it is possible to reduce the noise power in DAS. In our case, this rejection is carried out by an asymmetric Mach-Zehnder interferometer (MZI). The rejection of the SpBS wave is most relevant for broadband photodetectors, which are associated with the use of short probing pulses to achieve short gauge lengths in DAS.