bluuebunny/crossref_metadata_2025 huggingface dataset:
Cohort Profile: The China Northwest Cohort study
Authors: Li Chao , Liu Yezhou , Shi Guoshuai , Mi Baibing , Zeng Lingxia , Bi Yuxue , Li Qiang , Shen Yuan , Zhao Yaling , Pei Leilei , Kang Yijun , Xiao Shengbing , Liu Xin , Dai Jianghong , Zhang Yuhong , Wang Xinhua , Wang Xiaojie , Wang Duolao , Yan Hong , Dang Shaonong
Published: January 2021

BackgroundThe China Northwest Cohort study (CNC), a community population-based prospective observational study, aimed to investigate specific aetiology causes of NCDs and the long-term health hazards of NCDs in the northwest region of China with different ethnic groups.Study design and methodsA total of 118,572 participants (aged 35–74 years and including the Han, Uygur, Kazakh, Hui and Tibetan ethnic groups from five provinces of northwest China) were recruited between June 2018 and May 2019. Approximately 10% of the participants will be actively followed every 3 years via face-to-face interviews with the use of concise questionnaires to review risk exposures and disease incidence, as well as to review biological specimens, including blood, saliva and stool samples, which will be collected. Passive follow-ups will be conducted by periodic linking (every 6 months) of baseline survey data to establish electronic disease registries. The questionnaire survey, a regular medical examination and the storage of blood samples were conducted in the CNC baseline survey for all of the participants. Several other items from the medical examination were recorded for approximately 40% of the participants.DiscussionAmong the total participants, the proportions of Han, Uygur, Kazakh, Hui and Tibetan ethnicities were 75.3%, 13.0%, 1.7%, 8.2% and 1.3%, respectively. Many lifestyle and medical history factors were different across the ethnic groups. The genetic information from the multi-ethnic individuals, combined with abundant personal and environmental information, provided an important opportunity to reveal complex and specific mechanisms of the genetic and environmental factors associated with NCDs.
High Level of Mir-142-3P Expression in Peripheral Blood of Patients with Ovarian Carcinoma
Authors: Gider Yasemin , Jabbarli Xhariga , Uyaroglu Gamze , Tuncer Seref Bugra , Odemis Demet Akdeniz , Kurt Busra , Kilic Seda , Erdogan Ozge Sukruoglu , Celik Betul , Saip Pinar , YAZICI HÜLYA
Published: January 2021

Background
The most common cancers detected in women are breast, thyroid, colorectal, uterine corpus, lung, and ovarian cancer. Ovarian cancer is responsible from more than 150.000 death annually worldwide. This cancer is detected in the late stage, and is characterised with poor prognosis, therefore most cases result with death. The fact that this cancer manifests itself in the late stage and is characterized by a poor prognosis, is caused death in the majority of cases. Therefore, the diagnosis and the treatment of the disease have to be improved for a better quality of life for patients. MicroRNAs are the noncoding RNAs in the length of 19–24 nucleotides which show suppressor effect on target genes. miRNAs are included in the pathology of various diseases including cancer. miRNAs being as the biomarker candidates in diagnosis, and their use in treatment as the inhibitors of the molecules mimicking the miRNA showed that they may be used as the new therapeutic target and agents.
Methods
We detected with our group in our prior study conducted with disconcordant ovarian cancer twins that many miRNA molecules were different in ovarian cancer compared with the molecules in healthy sibling. The expression level of miR-142-3p that was selected from the miRNAs detected in the previous study was compared, and investigated in a wider ovarian cancer group, and in healthy control group. miR-142-3p expression level was investigated using the real-time PCR method in the present study involving 147 patients, and 100 healthy control group. The differences in the expression levels of miR-142-3p detected in the peripheral blood lymphocytes of ovarian cancer patients, and healthy control were statisticaly evaluated.
Results
The expression level of miR-142-3p was detected to have increased 3.11 fold in ovarian cancer patients compared with the levels in healthy controls, and the difference was statistically significant (p:0.00). These results suggest that miR-142-3p that was found significantly increased in the peripheral blood samples of ovarian cancer patients compared with the healthy controls might be used as a sensitive, noninvasive biomarker in the early diagnosis, and treatment and follow up of ovarian cancer.
Research on a ø6m TBM Steel Arch Splicing Manipulator
Authors: He Yuanfu , Xia Yimin , Xu Zhen , Yao Jie , Ning Bo , Xiao Xuemeng
Published: January 2021

As a challenging task, the robotic splicing of steel arch is required to realize the grasping and docking of steel arches in a limited space. The steel arches often have a mass of over 200kg and a length of over 4m. Due to the large volume and mass of steel arches and the high requirements for the positioning accuracy of splicing, it is difficult for the general manipulator to meet its flexibility and stiffness requirements. The single-degree-of-freedom(DOF) closed-loop mechanism has a simple and reliable structure. Adding it into the manipulator can effectively improve the dynamic performance and increase the structural stiffness. In this paper, a solution model of a single-DOF closed-loop planar mechanism is presented, and alternative kinematic pairs of the mechanism with different input constraints and output requirements are derived. Based on this model, a design method of steel arch splicing manipulator with single-DOF closed-loop grasping structure is proposed. All the optional basic configurations of the manipulator are deduced, and then the optimal configuration is obtained by using the performance indexes. A prototype of the steel arch splicing manipulator is manufactured, and the reliability of the manipulator is proved by experiments.
Optimizing Isobutanol Production in Engineered Cyanobacteria Using High Salinity Stress and Establishment of a Resource Recycling Strategy
Authors: Wu Xiao-Xi , Li Jian-Wei , Xing Su-Fang , Chen Hui-Ting , Song Chao , Wang Shu-Guang , Yan Zhen
Published: January 2021

Background: Isobutanol is an attractive biofuel with advantages. Third-generation biorefineries that convert CO2 into bio-based fuels have drawn considerable attention due to their lower feedstock cost and more ecofriendly refining process. Although autotrophic cyanobacteria have been genetically modified for isobutanol biosynthesis, it is still lack of stable and convenient strategies to improve the production.Results: In this study, we first engineered Synechococcus elongatus for isobutanol biosynthesis by introducing five exogenous enzymes, reaching a production titer of 0.126 g/L at day 20. It was then discovered that high salinity stress can significantly enhance isobutanol production five-fold with a maximal in-flask titer of 0.637 g/L at day 20. A comprehensive analysis of the osmotic-induced cells demonstrated that a series of physiological functional self-adjustment in S. elongatus, including altering metabolic profiles to accumulate redox equivalents, strength in antioxidative ability and weaken in membrane integrity, contributed to the isobutanol production titer. A cultivation system was then developed by mixing wastewater with seawater to grow the engineered cyanobacteria, reaching a similar isobutanol production titer as cultivation in the medium. Conclusions: High salinity stress on engineered cyanobacteria is a practical and feasible biotechnology to optimize isobutanol production. This biotechnology provides a prospect for biofuel production cost-effectively, and simultaneously recycles chemical nutrients from wastewater and seawater.
Analysis and Prediction of Epidemic Infectious Diseases Based on SEIDR Model -- A Case Study of COVID-19 in New York
Authors: Xu Zhigang , Xia Huiling
Published: January 2021

In the epidemic prevention and control of infectious diseases, improper prevention and control can easily lead to a large-scale epidemic. However, the epidemic of diseases follows certain rules, so it is very necessary to simulate the spread of infectious diseases, which can provide reference for the formulation of prevention and control measures. This paper proposes a SEIDR model for analyzing and predicting epidemic infectious diseases. Taking the development situation of COVID-19 in New York City as an example, firstly, the SEIDR model proposed in this paper was compared with the traditional SIR model, and it was found that the SEIDR model was better than the SIR model. Then the SEIDR model and the L-BFGS optimization method were used to fit the early transmission data of COVID-19 in New York City, and important parameters such as infection rate, latent morbidity rate, disease-related mortality and recovery rate were obtained. Moreover, the value of basic regeneration number 𝑅0 between 4.0 and 4.6 proved that the situation of COVID-19 in New York City was relatively serious. Finally, these parameters were used to predict the future development of COVID-19 in New York City, and the turning point of COVID-19 in New York City was found. However, even if the turning point be reached, the development trend of COVID-19 will not be controlled in the short term. Data verification shows that the SEIDR model established in this paper can effectively provide a scientific quantitative index for governments in the prevention and control of COVID-19 and other epidemic infectious diseases.
Consolidated bioprocessing of lignocellulose for production of glucaric acid by an artificial microbial consortium
Authors: Li Chaofeng , Lin Xiaofeng , Ling Xing , Li Shuo , Fang Hao
Published: January 2021

Background: The biomanufacturing of D-glucaric acid has been attracted increasing interest because it is one of the top value-added chemicals produced from biomass. Saccharomyces cerevisiae is regarded as an excellent host for D-glucaric acid production. Results: The opi1 gene was knocked out because of its negative regulation on myo-inositol synthesis, which is the limiting step of D-glucaric acid production by S. cerevisiae. Then we constructed the biosynthetic pathway of D-glucaric acid in S. cerevisiae INVSc1 opi1Δ and obtained two engineered strains, LGA-1 and LGA-C, producing record breaking titers of D-glucaric acid, 9.53 ± 0.46 g/L and 11.21 ± 0.63 g/L D-glucaric acid from 30 g/L glucose and 10.8 g/L myo-inositol in the mode of fed-batch fermentation, respectively. However, LGA-1 was more preferable because of the genetic stability and the outperformance in applications. So far, there have been no reports on D-glucaric acid production from lignocellulose. Therefore, the biorefinery processes including separated hydrolysis and fermentation (SHF), simultaneous saccharification and fermentation (SSF) and consolidated bioprocessing (CBP) were investigated and compared. CBP by an artificial microbial consortium composed of Trichoderma reesei Rut-C30 and S. cerevisiae LGA-1 was found to have relatively high D-glucaric acid titers and yields after 7 d fermentation, 0.54 ± 0.12 g/L D-glucaric acid from 15 g/L Avicel, and 0.45 ± 0.06 g/L D-glucaric acid from 15 g/L steam exploded corn stover (SECS), respectively. In attempts to design the microbial consortium for more efficient CBP the team consisted of the two members, T. reesei Rut-C30 and S. cerevisiae LGA-1, was found to be the best with excellent work distribution and collaboration.Conclusions: Two engineered S. cerevisiae strains, LGA-1 and LGA-C, with high titers of D-glucaric acid were obtained. This indicates that S. cerevisiae INVSc1 was an excellent host. Lignocellulose is a more preferable substrate than myo-inositol. SHF, SSF and CBP were studied and CBP by an artificial microbial consortium of T. reesei Rut-C30 and S. cerevisiae LGA-1 was found to be promising because of the relatively high titer and yield. T. reesei Rut-C30 and S. cerevisiae LGA-1were proved to be the best teammates for CBP. Further work should be done to improve the efficiency of this microbial consortium for D-glucaric acid production from lignocellulose.
Feasibility study of hospital antimicrobial stewardship analytics using electronic health records
Authors: Dutey-Magni Peter , Gill Martin J , Mcnulty David , Sohal Gurjit , Hayward Andrew , Shallcross Laura
Published: January 2021

Background: Hospital antimicrobial stewardship (AMS) programmes are multidisciplinary initiatives to optimise the use of antimicrobials. Most hospitals depend on time-consuming manual audits to monitor clinicians’ prescribing. But much of the information needed could be sourced from electronic health records (EHRs).Objectives: To develop an informatics methodology to analyse characteristics of hospital AMS practice using routine electronic prescribing and laboratory records.Methods: Feasibility study using electronic prescribing, laboratory and clinical coding records from adult patients admitted to six specialties at Queen Elizabeth Hospital, Birmingham, UK (September 2017–August 2018). The study involved: (1) a review of antimicrobial stewardship standards of care; (2) their translation into concepts measurable from commonly available EHRs; (3) pilot application in an EHR cohort study (n=61,679 admissions).Results: We developed data modelling methods to characterise the use of antimicrobials (antimicrobial therapy episode linkage methods, therapy table, therapy changes). Prescriptions were linked into antimicrobial therapy episodes (mean 2.4 prescriptions/episode; mean length of therapy of 5.8 days) enabling production of several actionable findings. For example, 22% of therapy episodes for low-severity community acquired pneumonia were congruent with prescribing guidelines, with a tendency to use antibiotics with a broader spectrum. Analysis of therapy changes revealed a delay in switching from intravenous to oral therapy by an average 3.6 days [95% CI: 3.4; 3.7]. Performance of microbial cultures prior to treatment initiation occurred in just 22% of antibacterial prescriptions. The proposed methods enabled fine-grained monitoring of AMS practice all the way down to specialties, wards, and individual clinical teams by case mix, enabling more meaningful peer comparison. Conclusions: It is feasible to use hospital EHRs to construct rapid, meaningful measures of prescribing quality with potential to support quality improvement interventions (audit/feedback to prescribers), engagement with front-line clinicians on optimising prescribing, and AMS impact evaluation studies.
Expression of miR-195 and its target gene Bcl-2 in human intervertebral disc degeneration and their effects on nucleus pulposus cell apoptosis
Authors: Lin Xue-Lin , Zheng Zhao-Yun , Zhang Qing-Shan , Zhang Zhen , An You-Zhi
Published: January 2021

Objective: To investigate the expression of miR-195 and its target gene Bcl-2 in intervertebral disc degeneration (IVDD) and its effect on nucleus pulposus (NP) cell apoptosis.Methods: The expressions of miR-195 and Bcl-2 in NP tissues of IVDD patients were quantified by qRT-PCR and Western blotting, respectively. NP cells were divided into Blank group, TNF-α group, TNF-α + miR-NC group, TNF-α + siBcl-2 group, and TNF-α + miR-195 inhibitors + siBcl-2 group. Cell proliferation was detected by MTT assay, cell apoptosis evaluated by flow cytometry, and mitochondrial membrane potential (MMP) tested by JC-1 staining. Moreover, the function of miR-132 on IVDD in vivo was investigated using a puncture-induced IVDD rat model.Results: IVDD patients had significantly increased miR-195 expression and decreased Bcl-2 protein expression in NP tissues. The expression of miR-195 was negatively correlated with the expression of Bcl-2 in IVDD patients. Dual-luciferase reporter gene assay indicated that Bcl-2 was a target gene of miR-195. In comparison with Blank group, TNF-α group showed decreased cell proliferation and MMP, increased cell apoptosis, up-regulated expression of miR-195, Bax and cleaved caspase 3, and down-regulated Bcl-2 protein, while these changes were attenuated by miR-195 inhibitors. Additionally, siBcl-2 can reverse the protective effect of miR-195 inhibitors on TNF-α-induced NP cells. Besides, inhibition of miR-195 alleviated IVDD degeneration and NP cell apoptosis in the rat model.Conclusion: MiR-195 was significantly up-regulated in NP tissues of IVDD patients, and inhibition of miR-195 could protect human NP cells from TNF-α-induced apoptosis via upregulation of Bcl-2.
Associations between antiretroviral therapy–related experiences and mental health status among people living with HIV in China: A prospective observational cohort study
Authors: Xie Jinzhao , Wang Zixin , Li Quanmin , He Qiangsheng , Xu Guohong , Li Yonghong , Zhou Kai , Li Linghua , Gu Jing
Published: January 2021

Background: Mental health problems (e.g., depression and anxiety) are among the most commonly reported comorbidities of HIV. Antiretroviral therapy (ART) coverage has increased sharply. The purposes of this prospective cohort study were to investigate the ART-related experiences and whether they were associated with mental health problems among a sample of people living with HIV undergoing ART in China.Methods: The participants were 400 people living with HIV who had started ART for the first time in Guangzhou city. They were followed-up one-year after ART initiation. Probable depression and moderate/severe anxiety were measured at baseline and Month 12, while experiences related to ART (e.g., side effects and regained self-confidence) were measured at Month 6. Univariate and multivariate logistic regressions were used to explore the associations between baseline characteristics, ART-related experiences and mental health status.Results: Among the 300 participants (75.0%) who completed all three surveys, a significant decline in prevalence of probable depression (23.0% at baseline vs. 14.0% at Month 12, P = 0.002) and moderate/severe anxiety (14.7% at baseline vs. 8.7% at Month 12, P = 0.023) was observed during the follow-up period. After adjustment for mental health status and potential confounders at baseline, a number of ART-related experiences at Month 6 were associated with probable depression and/or moderate/severe anxiety measured at Month 12. Improved physical health, relationships with sexual partners, and self-confidence were associated with decreased mental health issues, while the side effects of ART, AIDS-related symptoms, and inconvenience in daily life due to ART use were associated with increased mental health issues.Conclusions: ART-related experiences were associated with mental health problems, tailored mental health promotion interventions targeting these experiences are needed.
Antimicrobial Mitigation via Saponin Intervention on Escherichia coli and Growth and Development of Hydroponic Lettuce
Authors: Eylands Nathan J. , Evans Michael R. , Shaw Angela M.
Published: January 2021

Various saponins have demonstrated allelochemical effects such as bactericidal impacts as well as antimycotic activity against some plant pathogenic fungi, thereby acting to benefit plant growth and development. A commercial saponin solution was evaluated for bactericidal effects against Escherichia coli and growth of lettuce (Lactuca sativa) in a hydroponic system. E. coli (P4, P13, and P68) inoculum at final concentration of 108 colony-forming units (cfu)/mL was added to 130 L of a fertilized solution recirculating in a nutrient film technique (NFT) system used to grow ‘Rex’ lettuce. After 5 weeks in the NFT system, E. coli populations were lowest in the inoculated treatment that did not contain any saponin addition (0.89 log cfu/mL) when compared with all other inoculated treatments (P < 0.001). The treatment containing 100 µg·mL−1 saponin extract had an E. coli population of 4.61 log cfu/mL after 5 weeks that was higher than treatments containing 25 µg·mL−1 or less (P < 0.0001). Thus, higher E. coli populations were observed at higher saponin concentrations. Plant growth was also inhibited by increasing saponin concentrations. Fresh and dry shoot weight were both higher in the inoculated and uninoculated treatments without the saponin addition after 5 weeks in the NFT system (P < 0.0001). Lettuce head diameter was smaller when exposed to saponin treatments with concentrations of 50 and 100 µg·mL−1 (P < 0.0001). Lettuce leaves were also tested for the potential of E. coli to travel systemically to the edible portions of the plant. No E. coli was found to travel in this manner. It was concluded that steroidal saponins extracted from mojave yucca (Yucca schidigera) are not an acceptable compound for use in mitigation of E. coli in hydroponic fertilizer solution due to its ineffectiveness as a bactericide and its negative impact on lettuce growth.
CHALLENGES OF COVID-19 AEROMEDICAL RETRIEVAL: LESSONS LEARNT FROM CONDUCTING AEROMEDICAL TRANSFERS DURING A PANDEMIC
Authors: Ganesh Gihan , Christie Gayle , McIlroy David , Dutton Shelley , Challen Andrew
Published: January 2021

The COVID-19 pandemic has presented a unique and challenging environment for aeromedical organisations. We present lessons learnt during the development and implementation of our operational processes and procedures at The Royal Flying Doctor Service (RFDS) Western Operations for the transfer of suspected COVID-19 patients. To date, we have conducted 105 such fixed-wing transfers. The unique geography and health care system of Western Australia mandates that long-range, fixed-wing transfers are often required to centralised tertiary care. These lessons learnt provide a framework for the essential logistical, equipment and human factor considerations for developing an effective system. The translation of predominantly hospital-centric protocols into the aviation environment requires careful forethought, effective leadership and teamwork. Conducting COVID-19 suspected aeromedical retrievals significantly impacts all aeromedical retrieval operations and aeromedical personnel that should be realised by an aeromedical organisation.
VENOUS THROMBOEMBOLISM
Authors: MacKellar Rachel
Published: January 2021

Venous thromboembolism (VTE) is the condition in which blood clots form within the venous circulatory system, and consist of DVT (deep vein thrombosis) and PEs (Pulmonary emboli).

It is a common condition, with an estimated life-time risk of 8% and an annual incidence of 0.84-1 per 1000 population1, 2 and represents a significant economic burden: within Australia the annual estimated cost in 2018 being $1.72 billion AUD3.

The condition is considered aeromedically significant for both aircrew and passengers; diagnosis and treatment may have implications on an aviators medical certificate and the general public are often concerned about developing “economy class syndrome”.

This paper reviews the pathophysiology of VTE, the relationship between VTE and its treatment in the aviation environment. It also reviews some of the international aeromedical regulatory guidelines and provides a suggested approach to certification in case of VTE.
Pseudomorphic 9-line silician ferrihydrite and Fe-rich serpentine-group minerals in FeTi oxide-rich ferroan peridotite, Laramie anorthosite complex, Wyoming, U.S.A.
Authors: Evans Bernard W. , Kuehner Scott M. , Joswiak David J.
Published: January 2021

Low-temperature hydrous alteration of FeTi oxide-rich ferroan peridotite, Laramie anorthosite complex, Wyoming, produced silician ferrihydrite, cronstedtite, greenalite, hisingerite, and talc. Ferrihydrite occurs as nanocrystals in ~50 nm diameter granules that form monomineralic masses up to 300 μm across. It is inferred to have formed by the replacement of an igneous sulfide such as pyrrhotite. Electron diffraction shows the ferrihydrite to be a 9-line variety. Si-rich cronstedtite formed thin rims around the ferrihydrite, and talc grew patchily around the cronstedtite. Greenalite formed in ~10 μm cracks through all the above minerals and olivine, and hisingerite microveinlets partially replaced olivine. Igneous minerals remaining include olivine Fa46, magnetite, ilmenite, hornblende, biotite, and trace clinopyroxene. Correlations among the constituents of ferrihydrite determined by electron microprobe, including anhydrous totals, indicate progress during the growth of two charge-balanced exchanges involving silica enrichment: an inverse cronstedtite substitution (MgFe2+,Si) (Fe3+Mn3+)–2 and an inverse hydrogarnet substitution SiH–4. The cronstedtite exchange requires charge and size balance across nearest-neighbor T and O crystal sites, suggesting crystal-interior rather than crystal-surface control. Ferrihydrite’s composition reflects time- and space-related variations in the chemical potentials of components in the hydrous fluid at the site of alteration. An upper limit for SiO2 of 14–15 wt%, or ≈1.0 Si per 5-cation formula unit, would seem to correspond to the limit of availability in ferrihydrite of tetrahedral sites open to the entry of Si. Our EPMA data, projected to zero SiO2, indicate an anhydrous total of ≈83 wt% for end-member ferrihydrite, a number that matches the formula: Fe10O15·9H2O. The geochemical properties of Laramie ferrihydrite are shared by some samples of altered chondritic and Martian meteorites. Ferrihydrite on Earth commonly occurs as a surface deposit; unlike the Laramie occurrence, these lack the microspatial coherence of replacements/pseudomorphs to show systematic, structure-related element variations. The superior crystal quality of the Laramie ferrihydrite likely contributed to its unique compositional variability.
Re-examination of the heterotype solid solution between calcite and strontianite and Ca-Sr fluid-carbonate distribution: An experimental study of the CaCO3-SrCO3-H2O system at 0.5–5 kbar and 600 °C
Authors: Schiperski Ferry , Liebscher Axel , Gottschalk Matthias , Franz Gerhard
Published: January 2021

Carbonates are excellent carriers for divalent cations such as Ca, Mg, and Sr, and knowledge about their stability and solid solutions is important to understanding the global strontium cycle. To shed light on the topology of the two-phase field between calcite-type and aragonite-type (Ca,Sr)CO3 solid solutions as a function of temperature and pressure, and to learn more about the distribution of Sr and Ca between carbonates and fluid, we studied the system CaCO3-SrCO3-H2O at 600 °C in the pressure range 0.5–5 kbar. Conventional and rapid-quench hydrothermal syntheses were performed using a range of different starting materials. All bulk compositions were within the assumed/postulated two-phase field of calcite-type and aragonite-type (Ca,Sr)CO3 solid solutions. The run products were analyzed by scanning electron microscopy, electron microprobe analysis, and powder X-ray diffraction with Rietveld refinement. The results show that the heterotype solid solution is more extensive than previously assumed, with calcite incorporating up to 20 mol% SrCO3, which is twice as much as previously predicted. The compositional range of the aragonite-type solid solution was identical to that found in the literature. Using the data from this study, an updated version of the phase diagram P-X (Sr) at 600 °C for the CaCO3-SrCO3 system was calculated. The phase diagram does not support a phase transition within the trigonal (Ca,Sr)CO3 solid solution associated with rotational disorder of the CO3-groups. This order-disorder phase transition was previously postulated to explain some observed compositional trends in this system. Our new data are in line with other more recent studies. The distribution of Sr and Ca between the fluid and solid phases D = XSrsolid/XSrfluid  is near to 1.0 for calcite-type and on average around 2.0 for aragonite-type solid solutions. This contrasts with silicate-fluid systems in which Sr typically shows a strong preference for the fluid phase compared with Ca.
A Rayleigh model of cesium fractionation in granite-pegmatite systems
Authors: London David
Published: January 2021

The K/Cs ratios of K-feldspars from granitic pegmatites are compared to models derived from the Rayleigh equation. The K/Cs and K/Rb ratios of K-feldspars and micas exhibit decreasing values when plotted against their Cs or Rb contents across cogenetic suites of granites and pegmatites and from margin to core of individual bodies. The trends in elemental ratios conform to Rayleigh fractionation for the crystallization of feldspars and micas from a silicate melt. Within two individual pegmatite bodies, the K/Cs ratio of K-feldspar initially falls more rapidly than the Rayleigh model predicts. That might reflect a local increase in the concentration of Cs relative to K due to the pile-up of incompatible elements in a boundary layer of melt adjacent to the crystal growth front. The addition of an aqueous solution to the Rayleigh model (i.e., the simultaneous crystallization of K-feldspars from melt and from aqueous solution) predicts high and increasing K/Cs ratios of K-feldspars that are not observed in natural rock suites, except when K-feldspars crystallize in miarolitic cavities or when primary K-feldspar recrystallizes to microcline perthite in an open hydrothermal system. In those cases, the Cs content of K-feldspars falls to nil because of the high solubility of Cs in aqueous solution and low compatibility of Cs in K-feldspar. Otherwise, the observed patterns of K/Rb or K/Cs in K-feldspar and micas in pegmatites conform to crystal-melt fractionation in which an aqueous solution plays no part. From the viewpoint of the geochemistry of Cs in pegmatites, these observations give support to the model proposed by Cameron et al. (1949) and endorsed by Jahns (1953a, 1953b).
Copper removal from semiconductor CMP wastewater in the presence of nano-SiO2 through biosorption
Authors: Wang Xiaoyu , Buer Gude , Fan Wei , Gao Lei , Huo Mingxin
Published: January 2021

Copper-bearing wastewater from chemical mechanical planarization (CMP) is a typical semiconductor development byproduct. How to effectively treat Cu2+ in the CMP wastewater is a great concern in the microchip manufacturing industry. In this study, we investigated the potential for the microbial removal of Cu2+ by a multiple heavy metal-resistant bacterium Cupriavidus gilardii CR3. The environmental factors, including pH, nano-SiO2, ionic strengths, and initial concentrations of Cu2+, and adsorption times on the bioremoval of Cu2+ in CMP wastewater were optimized. Under optimal condition, the maximum biosorption capacity for Cu2+ was 18.25 mg g−1 and the bioremoval rate was 95.2%. The Freundlich model is described well for the biosorption of Cu2+ in CMP wastewater in the presence of nano-SiO2 (R2 = 0.99). The biosorption process obeyed the pseudo-second-order kinetic equation (R2 > 0.99). In the column experiment, the advection–dispersion–retention model fitted the breakthrough curve of all experiments well (R2 > 0.95). The attachment coefficient in the sand matrix coated by CR3 biofilm was 2.24–2.80 times as that in clean sand. Overall, C. gilardii CR3 is a promising candidate to remove Cu2+ from CMP wastewater. Nano-SiO2 in CMP wastewater did not inhibit the bioremoval of Cu2+ but showed a slight promotion effect instead.
Comparison of methods for nitrous oxide emission estimation in full-scale activated sludge
Authors: Myers Shanna , Mikola Anna , Blomberg Kati , Kuokkanen Anna , Rosso Diego
Published: January 2021

Nitrous oxide (N2O) gas transfer was studied in a full-scale process to correlate liquid phase N2O concentrations with gas phase N2O emissions and compare methods of determining the volumetric mass transfer coefficient, KLa. Off-gas and liquid phase monitoring were conducted at the Viikinmäki wastewater treatment plant (WWTP) over a two-week period using a novel method for simultaneous measurement of dissolved and off-gas N2O and O2 from the same location. KLa was calculated with three methods: empirically, based on aeration superficial velocity, from experimentally determined O2 KLa, and using a static value of best fit. The findings of this study indicated trends in local emitted N2O consistently matched trends in local dissolved N2O, but the magnitude of N2O emissions could not be accurately estimated without correction. After applying a static correction factor, the O2 method, using experimentally determined O2 KLa, provided the best N2O emission estimation over the data collection period. N2O emissions estimated using the O2 method had a root mean square error (RMSE) of 70.5 compared against measured concentrations ranging from 3 to 1,913 ppm and a maximum 28% error. The KLa value, and therefore the method of KLa determination, had a significant impact on estimated emissions.
Zur ökologischen Bildersprache bei den alttestamentlichen Propheten
Authors: Najda Andrzej
Published: January 2021

The prophets of the Old Testament in the fulfillment of their task of proclaiming God’s word make use of various literary forms and frequently use pictures from different disciplines of life, in order to be understandable for their listeners, in order to convince them and to make impression on them, they especially willingly make use of pictures taken from the sphere of ecology, making different comparisons and metaphors, these generally concern God, His action towards Israel and the Chosen Nation itself.
Sztuczne zapłodnienie z perspektywy bioetyki rodziny
Authors: Ciszek Mariusz
Published: January 2021

In this article I am going to present the moral problems of artificial insemination from the new discipline- bioethics of a family perspective, this branch of bioethics deals with the moral appreciates of contemporary technical civilization influence function of the family’s environment, the author takes for granted that health and life are an individual right of every man, which has the social aspect too, connected with family. It results from a fact that all disturbances in a family’s environment have a negative influence on the life and function of an individual, which also contribute to regress of social potential. A family is an unconditional right of every man, which should be protected. In this publication I am going to present the problem of artificial insemination, which constitutes an integral part of the bioethics of a family, the main criterion of moral appreciation is a right of a child.
Ciało - źródło grzechu czy powód do chwały w świetle poglądów Tertuliana
Authors: Filipowicz Adam M.
Published: January 2021

The article considers human body in teaching of Tertullian, one of the famous early Christian writers and an important apologist of Christianity. It consists of five parts: 1. Introduction; 2. Despise body in ancient philosophical thought; 3. Dignity of body according to Tertullian; 4. Human body and responsibility for evil and sin; 5. Summary.
Panorama cywilizacji zrównoważonego rozwoju
Authors: Skowroński Antoni
Published: January 2021

Artykuł dotyczy koncepcji zrównoważonego rozwoju (sustainable development) osadzonej w kontekście zmian kulturowych i cywilizacyjnych. Można ją traktować jako alternatywę i nową panoramę, otwierającą perspektywiczne widoki na dalszy trwały i zrównoważony rozwój cywilizacyjny. Idea ta, jest globalną strategią rozwoju. Polega na włączeniu środowiska naturalnego do rozwoju społeczno-gospodarczego regionu, kraju czy w ujęciu globalnym całego świata. Zakłada trwałą poprawę jakości życia współczesnych i przyszłych pokoleń, co integralnie łączy się z poprawą stanu środowiska człowieka. Wskazuje też na potrzebę rozwoju duchowego człowieka i zamianę celów rozwojowych z materialnych na niematerialne. W tych ogólnych założeniach i celach, zrównoważony rozwój napotyka na wiele praktycznych i mentalnych problemów, które hamują, bądź wręcz uniemożliwiają efektywne wprowadzanie tej koncepcji w życie.
Podstawowe zasady międzynarodowej ochrony środowiska morskiego. Wybrane aspekty prawa, doktryny i praktyki
Authors: Łukaszuk Leonard
Published: January 2021

The author of this article presents the notion and meaning of international protection of the marine environment and offers a solid legal and philosophical background to this issue. He points at and systematically analyzes a kind of compendium of selected main legal and philosophical principles as environmental values, included in the United Nations Convention on the law of the sea (1982). The author discusses both environmental management at seas as a global system and topical issues in the light of international legal instruments, doctrine, and some practical experiences. He also shows the environmental law as an increasingly important area of new interdisciplinary study and addresses how this law and science may best able to address the key issues facing the marine environment in the 21st century.
Biodiesel, a ochrona środowiska
Authors: Owczuk Marlena
Published: January 2021

The development of the automotive industry in the world causes high environmental degradation, the main source of this degradation is engine emissions. It is necessary to introduce biofuels prepared from renewable energy sources to the market due to the limited reserve of crude oil and environmental protection. Appropriate new modifications in law regulations have been prepared in European Union. Introducing alternative fuels can reduce the emissions of harmful gases and also decrease the level of pollutions in the environment.
Wiedza i poglądy nauczycieli religii na tematy związane z ochroną i kształtowaniem środowiska naturalnego
Authors: Czartoszewski Jacek W.
Published: January 2021

The article contains an analysis of the investigation about the knowledge and ideas of religion teachers as regards the protection and the shaping of the natural environment and presents the primary problems of the questionnaire, this was carried out in the Diocese of Lomza with a group of 260 people.
Droga do świadomości ekologicznej
Authors: Strumińska-Doktór Anna
Published: January 2021

Streszczenie nie jest dostępne.
Formy doskonalenia zawodowego nauczycieli katechezy
Authors: Jagodzińska Małgorzata , Buchcic Elżbieta
Published: January 2021

Streszczenie nie jest dostępne.
Współpraca szkoły ze środowiskiem lokalnym
Authors: Buchcic Elżbieta , Żeber-Dzikowska Ilona
Published: January 2021

Streszczenie niejest dostępne.
Wykorzystanie środowiska lokalnego dla kształtowania postaw na rzecz zrównoważonego rozwoju
Authors: Buchcic Elżbieta
Published: January 2021

Streszczenie nie jest dostępne.
Review of Evidence and Perspectives of Flavonoids on Metabolic Syndrome and Neurodegenerative Disease
Authors: Zilli Aline M. Hilzendeger , Zilli Eduardo M.
Published: January 2021

Flavonoids are commonly found in fruits, vegetables, and plant-derived foods and may
promote various health benefits when included in the diet. The biological activity of flavonoids is
normally associated to their potent antioxidant and anti-inflammatory effects, since oxidative stress
is associated to conditions such as diabetes, obesity, cardiovascular and neurodegenerative diseases.
Additionally, flavonoids may be related to metabolic diseases through their effects on inflammatory
mediators and pathways, barrier integrity and gut microbiota composition. The extensive
metabolism undergone by flavonoids in humans and the individual differences in their bioavailability
to target organs hinder the interpretation of results from cell and animal models. Prospective human
studies therefore provide an important perspective. In the field of neurodegenerative disease,
carefully designed cohort studies have uncovered important associations between flavonoid intake
and reduction in dementia risk, especially regarding specific flavonols, but also anthocyanins. Alternative
mechanisms of action, such as changes in the gut microbiota or modulation of the production
of toxic proteins, such as amyloid and tau, likely account for an important component of their
positive effects, and their elucidation may lead to public health benefits of large magnitude.
Antiviral Effects of Asian Natural Products Targeting SARS, MERS, and COVID-19
Authors: Sonju Jafrin Jobayer , Anwar Md. Rafi , Azad Md. Abul Kalam , Sultana Umme Habiba , Niloy Kumar Kulldeep , Das Sajan
Published: January 2021

:

diseases initiated by Coronavirus (CoV) have become the major public health
problems worldwide in the last two decades. The recent emergence of the deadly COVID-19 due to
SARS-CoV-2 has created unprecedented pandemic situations around the globe making the need for
antiviral molecules to treat it. Encountering the health conditions of the patients with synthetic
molecules has shown some unpredictable results, including side effects. To face this complex situation,
natural products can be good sources of enormous treatment options with fewer side effects.
Wide diversity, easy availability, and a good number of scientific researches on Asian origin natural
products can be a great tool to meet this critical situation. This paper reviews the currently available
Asian natural products with potential antiviral effects on CoV. It includes the potential natural
products of whole plant extract, partial plant extract, isolated pure compounds, and isolated pure
set of compounds. Besides, the available information of in vitro and in silico from very recent papers
are also summarized for the ease of future research. As a rapid search for a potential anti-CoV
therapy is undergoing, Asian natural products will provide promising results but still, there are
many challenges in front of us, including the robust in vitro assay to confirm the antiviral property,
toxicity analysis, and fulfillment of regulatory needs. The use of appropriate natural products with
the potential for a safe and more effective anti-CoV property requires multidisciplinary research
with preclinical and clinical researchers, which will improve their clinical applications.
Multiple intelligences and learning problems
Authors: Zambrano Alberto Stalin Barcia , Zambrano Gema Alejandra Briones , Vergara Gema Maria Mendoza
Published: January 2021

Today many researchers, especially educational researchers, are preparing to learn a little more about intelligence, its characteristics, and singularities. The purpose of this investigation was to carry out an analysis of multiple intelligences and learning problems in the students of the upper basic level, from an Educational Unit of the Province of Manabí, the investigation was carried out using the investigative bibliographic method, to know the foundations of multiple intelligences and the reasons for learning problems. The compilation of scientific information from reliable sources was made, carrying out an analysis based on the observation of the students, showing the difficulties that the students and teachers present in the teaching-learning process.
Responsabilidad de proteger y revolución, el rol de las Naciones Unidas en la guerra civil libia
Authors: Mejía Prieto Juan Camilo
Published: January 2021

El presente capítulo aborda las dinámicas que desencadenaron la primera guerra civil libia, a través de un recorrido histórico que termina con el inicio de la era repu-blicana, profundamente marcada por la ideología gadafista. Se exponen los antecedentes inmediatos que originaron las hostilidades, así como las partes enfrentadas y su respectiva valoración de potenciales. Se aborda, igualmente, la significativa participación de la otan (en cabeza, principalmente, de Estados Unidos., Reino Unido y Francia) en cumpli-miento de las resoluciones emitidas por el Consejo de Seguridad de las Naciones Unidas, evidenciando la clara alianza militar entre actores estatales y no estatales, que finalmente derrocaron al régimen tras la muerte del dictador. Finalmente, se cierra con un recorrido cronológico a través del desarrollo de la campaña militar, para concluir, a través de una breve discusión, con las implicaciones de esta intervención en la seguridad internacional y, en particular, en la denominada ‘responsabilidad de proteger’.
What happened to temps? Changes since the Great Recession
Authors: Mann Amar , Luo Tian , Holden Richard
Published: January 2021

The temporary help services (THS) industry has grown in absolute and relative terms since 1990, and also since the Great Recession, from 2008–18, the period covered in this article. The THS employment levels have fluctuated in advance of broader economic changes, providing a method for employers to scale employment up and down to meet changing conditions. As the economy has changed, so too has the deployment of THS employees. Trends in the THS industry follow overall employment trends and also shine a light on changes in the regional, occupational, and industrial utilization of THS employees. These trends in THS employment underscore the key features of the labor market that underlie the overall employment trends. THS employment is, in many ways, a barometer for the employment changes in the U.S. economy.
Examining the Relationship Between the Use of a Mobile Peer-Support App and Self-Injury Outcomes: Longitudinal Mixed Methods Study
Authors: Kruzan Kaylee Payne , Whitlock Janis , Bazarova Natalya N
Published: January 2021

Background

Many individuals who self-injure seek support and information through online communities and mobile peer-support apps. Although researchers have identified risks and benefits of participation, empirical work linking participation in these web-based spaces to self-injury behaviors and thoughts is limited.

Objective

This study aims to investigate the relationship between behavioral and linguistic traces on a mobile peer support app and self-injury outcomes.

Methods

Natural use data and web-based surveys (N=697) assessing self-injury outcomes were collected from 268 users (aged 13-38 years; median 19; 149/268, 55.6% female) of a mobile peer-support app for 4 months. Participants were identified as having posted self-injury content using an internal classifier. Natural log data was used to predict self-injury outcomes in a series of multilevel logistic and linear regressions.

Results

Greater engagement on a mobile peer-support app was associated with a decreased likelihood of self-injury thoughts (odds ratio [OR] 0.25, 95% CI 0.09-0.73) and fewer intentions to self-injure (b=−0.37, SE 0.09), whereas posting triggering content was associated with an increased likelihood of engaging in behaviors (OR 5.37, 95% CI 1.25-23.05) and having self-injury thoughts (OR 17.87, 95% CI 1.64-194.15). Moreover, viewing triggering content was related to both a greater ability to resist (b=1.39, SE 0.66) and a greater intention to self-injure (b=1.50, SE 0.06).

Conclusions

To our knowledge, this is the first study to connect naturally occurring log data to survey data assessing self-injury outcomes over time. This work provides empirical support for the relationship between participation in online forums and self-injury outcomes, and it articulates mechanisms contributing to this relationship.
Pengembangan Media Transpor untuk Koleksi Sampel Preputium, untuk deteksi Bovine Genital Campylobacteriosis
Authors: Beniawan Apris , Indrawati Agustin , Pasaribu Fachriyan Hasmi
Published: January 2021

Campylobacter fetus subsp. Venerealis (Cfv) is bacteria causing contagious genital diseases in cows called Bovine Genital Campylobacteriosis (BGC) or vibriosis. Isolation of Cfv is difficult, because the bacteria are fragile and need specific nutrients and oxygen (5-10%). The transport media is very important to maintain Cfv survival before culturing in laboratory. The aim of this study was to modify a new transport media as an alternative media for Cfv. Developed media capability was compared to Weybridge media, and Phosphate Buffered Saline (PBS). All transport media was contaminated by Cfv with concentrations of 105,104,103,102,101 (CFU/ml), and was stored for <6, 24, 48, 72, and 96 hours in each transport medium before culturing on blood agar, all in triplicate. The quality of transport media was analyzed based on bacterial growth on blood agar. PCR test was used as a confirmatory test of growing bacteria cultured on blood agar. Based on culture results, Cfv stored in three transport mediums for <6 hours, Cfv grew on blood agar from all concentration levels provided. Cfv stored for 24, 48, 72 and 96 hours on PBS did not grow, whereas on developed media and Weybridge media, the bacteria could grow and enrichment occurs at all concentration levels given. This study indicated the developed media can be used as an alternative transport medium for Cfv bacteria.