bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of the C4.5 Algorithm by Using a Genetic Algorithm for the Diagnosis of Life Expectancy for Hepatitis Patients
Authors: Riantik Margareta Ayu , Arifudin Riza
Published: November 2022

As technology develops rapidly, the amount of data generated experiencing rapid development, including medical data. Data can help diagnose the life expectancy of people with the disease such as hepatitis using data mining methods in the medical field. In this research, technique data mining uses a classification technique with the C4.5 algorithm and the UCI Machine Learning Repository dataset. This dataset has 19 attributes, 1 class, and 155 samples. C4.5 algorithm is optimized using the Genetic Algorithm feature selection process. This study compares the accuracy of the C4.5 algorithm before and after optimization using a Genetic Algorithm. C4.5 algorithm produces the highest accuracy of 96.23%. Meanwhile, the C4.5 algorithm, after being optimized using Genetic Algorithm, has the highest accuracy of 98.11%. The number of features selected is 15 features. Application of Genetic Algorithms in C4.5 algorithm is proven to improve the accuracy in diagnosing life expectancy of people with hepatitis as much as 1.88%.
Recycling routes of lithium-ion batteries: A critical review of the development status, the process performance, and life-cycle environmental impacts
Authors: Wagner-Wenz Ronja , van Zuilichem Albert-Jan , Göllner-Völker Laura , Berberich Katrin , Weidenkaff Anke , Schebek Liselotte
Published: November 2022

Today, new lithium-ion battery-recycling technologies are under development while a change in the legal requirements for recycling targets is under way. Thus, an evaluation of the performance of these technologies is critical for stakeholders in politics, industry, and research. We evaluate 209 publications and compare three major recycling routes. An important aspect of this review is that we tackle the need for a critical evaluation of these recycling routes by introducing clear terms and creating a structuring scheme. Our evaluation criteria cover three areas: status of development, process performance, and life-cycle environmental impacts. With respect to development status, we provide an analysis of today’s market. A criterion of process performance is recycling efficiency, which today focuses on the mass of the recovered materials. To include the contributions of critical materials, we add a criterion for the efficiency of recovery of materials. Life-cycle assessments provide information on gross impacts, benefit of substituting virgin material and net impact. Present life-cycle assessments focus on waste management rather than on recovery of critical materials. This review contributes to an understanding of these trade-offs and supports discussion as to what is the “best” recycling route when targets conflict.

Graphical Abstract

There are three possible process sequences for each lithium-ion battery-recycling route. A distinction is made between pre-treatment steps (gray), direct physical treatment steps (green), pyro-metallurgical treatment (orange), and hydro-metallurgical treatment (blue). The figure is based on a figure from Doose et al. (Joule 3:2622–2646, 2019).
A Case Report: Mucinous Tubular and Spindle Cell Carcinoma of Kidney with Spindle Cell Predominance Mimicking Mesenchymal Tumour
Authors: Natarajan Ramya , Murhekar Kanchan  , Raja Anand  , Sundersingh Shirley
Published: November 2022

Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is a rare variant of renal cell carcinoma which was first described in the 2004 World Health Organization classification of tumours of the kidney. Morphologically, MTSCC is composed of tubules merging with blandappearing spindle cells in a myxoid/mucinous stroma. Diverse morphological patterns have been reported in MTSCC; however, a spindle cell predominant morphology mimicking a mesenchymal tumour is rare and only two cases have been reported so far. We report a case of MTSCC with spindle cell predominance in kidney which was a diagnostic challenge. Though MTSCC usually shows an indolent course, there have been cases showing aggressive behaviour even with bland morphology. Hence, a thorough histopathological evaluation with ancillary studies are required to differentiate spindle cell predominant MTSCC from its mimics. Our case was a 40-year-old female who was incidentally found to have a well-defined hypodense lesion measuring around 2 cm in the upper pole of the right kidney. Right partial nephrectomy was performed which showed a 2.7 × 2.5 × 2 cm well-defined grey tan tumour without necrosis or haemorrhage, limited to kidney. Histopathological examination showed sheets of bland-appearing spindle cells mimicking a mesenchymal tumour. The tumour was extensively sampled, revealing small foci of tubule formation and mucinous stroma. Tumour cells were positive for CK7, AMACR, and PAX8. A final diagnosis of MTSCC was made. Hereby, we discuss ways of differentiating MTSCC from other spindle cell tumours of the kidney.
Filaggrin Defect at Atopic Dermatitis: Modern Treatment Options
Authors: Murashkin Nikolay N. , Opryatin Leonid A. , Epishev Roman V. , Materikin Alexander I. , Ambarchian Eduard T. , Ivanov Roman A. , Savelova Alena A. , Nezhvedilova Roza Y. , Rusakova Lyudmila L.
Published: November 2022

Atopic dermatitis is a common chronic skin disease, its pathogenesis is associated with congenital or acquired deficiency of filaggrin protein. In recent years, extensive evidence on the causes of filaggrin deficiency has been obtained. The structure and functions of this protein are described, that opens new approaches for atopic dermatitis management.
Microsporia in Young Children: Clinical Cases
Authors: Yakovlev Alexey B. , Polonskaya Aleksandra S. , Kruglova Larisa S.
Published: November 2022

Background. Microsporia is a zooanthroponotic mycosis of skin and hair caused by fungi genus Microsporum. Microsporia is most common among children, including infants. The microsporia incidence has slow steady increase over recent years.

Clinical cases description. Follow-up results of two children of different ages (younger/older than 1 year) with microsporia are presented. Successful management approach is shown. Major limitations of drug therapy in infants as well as common therapeutic errors were analyzed.

Conclusion. Diagnosis and management of microsporia in infants and young children is a challenging task. Major errors in microsporia management in patients of these age groups are associated with peculiarities of clinical picture as well as limited variations of drugs that are appropriate for the requirements on efficacy and safety of therapy among young children.
Physical Development and Puberty in Related Patients with Kindler Epidermolysis Bullosa: Case Study
Authors: Leonova Maria A. , Murashkin Nikolay N. , Dvornikov Anton S. , Pronina Irina Yu.
Published: November 2022

Background. Kindler epidermolysis bullosa is orphan, autosomal recessive disease and it is one of the variants of congenital epidermolysis bullosa. Its severe course is characterized by high risk of multifactorial malnutrition, chronic inflammation due to recurrent secondary skin infections, and also bone metabolism disorders, what can lead to disorders in physical development and puberty in children. However, the effect of Kindler epidermolysis bullosa on patients’ physical development and puberty remains unexplored.

Clinical case description. Family case of Kindler epidermolysis bullosa was presented in 13 and 12 years old patients, third degree of kinship (maternal, uncle — nephew) with typical clinical manifestations for this disease. The diagnosis was confirmed in both patients via Sanger sequencing and revealing identical pathogenic variants in the FERMT1 gene (two deletions in the compound-heterozygous state — c.778del, p.Q260Kfs*21 and c.1088del, p. L363Wfs*39). Reduced concentrations of testosterone and 25(OH)D were revealed, whereas, increased concentration of adrenocorticotropic hormone — only in the older patient. The concentrations of luteinizing hormone, follicle-stimulating hormone and estradiol in both patients were within the reference values. The younger patient had prepubertal sizes and volume of testicles. Both patients had specific features of psychoemotional state: mood swing with rapid increase in anxiety level in the older patient and difficulties in emotional-volitional regulation in younger one.

Conclusion. Patients with Kindler epidermolysis bullosa have high risk of physical development and puberty delay due to its systemic chronic pathological process. Thus, these patients require dynamic follow-up by pediatrician and pediatric endocrinologist.
Serum Sickness-Like Reaction Associated with Epstein – Barr Virus: Clinical Case
Authors: Ivanchikov Vladislav V. , Murashkin Nikolay N. , Ambarchian Eduard T. , Kuzminova Anastasia D.
Published: November 2022

Background. Annular dermatoses are a group of diseases with major clinical manifestation of rashes of relevant form. This manifestation pattern causes difficulties in diagnosis. The case of rarely diagnosed annular dermatosis is presented: serum siknesslike reaction (SSLR) triggered by the Epstein – Barr virus (EBV).

Clinical case description. Patient D., 8 years old girl, noted abdominal pain 3 weeks before hospitalization, and later numerous polymorphic rashes (erythematous macules, urticarial elements), swelling and pain in joints. Self-treatment with non-steroidal anti-inflammatory and systemic antihistamines did not lead to any improvement. The patient was hospitalized in the pediatric department at the place of residence, where the diagnosis “Henoch-Schonlein purpura, mixed type” was established according to the results of physical, laboratory (double increase of ALT and AST, ESR up to 166 mm/h, IgM to EBV), and ultrasound (mesenteric lymph nodes hyperplasia) studies. Systemic glucocorticosteroids have led to improvement, however, few days after the end of the treatment there was relapse of rash and arthralgia. Thus, the girl was administrated to clinical diagnostic center. Patient’s general condition was satisfactory at the time of examination. There were numerous erythematous annular urticarial and macular elements (3–12 cm) on the skin of face, body and limbs. Some foci, as well as some resolved rashes had blue spots with indistinct boundaries that disappeared after compression. Mucous membranes, nails and hair were intact. Subjective symptoms — slight burning around rashes, at palpation — low-intensity pain in the left radiocarpal joint. Blood tests: C-reactive protein concentration increased up to 12 mg/L, ESR up to 26 mm/h, IgG to EBV up to 47.7.

Conclusion. During differential diagnosis we should consider the possibility of SSLR development in all pediatric patients with annular rashes associated with arthralgia and/or arthritis, fever, history of drug use (most often beta-lactam antibiotics), recent vaccination or manifestations of viral infection, especially in case of cyanotic spots after rashes resolution and non-specific laboratory parameters.
Administration Details of Genetically Engineered Biologic Drug (Ustekinumab) in Children with Psoriasis and Comorbid Metabolic Syndrome or in Case of Previous Biological Therapy Failure: Case Studies
Authors: Ivanov Roman A. , Murashkin Nikolay N.
Published: November 2022

Background. Psoriasis is a chronic immune-mediated disease with multifactorial nature. It often requires administration of genetically engineered biologic drugs. They have a number of features and risks that depend on various factors. The results of ustekinumab administration as a drug of choice in patients with comorbid metabolic syndrome in a child with Down syndrome, as well as a case of inefficacy of previous biologic therapy with inhibitors are considered.

Clinical cases description. Two clinical cases of ustekinumab administration in children with severe psoriasis have been described. In the first case, we had to choose systemic therapy for the child suffering from Down syndrome and having complex comorbid background: obesity and steatohepatitis. The second case was interesting due to the family history of psoriasis in the patient, who received methotrexate for a long time, and then etanercept with subsequent loss of efficacy and severe disease aggravation without any pathogenetic therapy.

Conclusion. Ustekinumab is the favorable genetically engineered biologic drug (according to the studies results and the clinical cases data) for children with severe psoriasis who have comorbid pathologies and who require the change in biologic agent due to its inefficacy.
Face Lesions in En Coup De Sabre Scleroderma in Children: Modern Treatment and Outcomes Improvement
Authors: Murashkin Nikolay N. , Savelova Alena A. , Misbakhova Alina R.
Published: November 2022

Localized scleroderma (LS) is an inflammatory sclerosing disease of the skin and subcutaneous tissues associated with its atrophy. Commonly, LS is a benign self-limited disease, although, the chronic form of this disease is recurrent. Particular attention is paid to the research of treatments methods that could eliminate not only immune-mediated mechanisms, but also its outcomes (such as gross cosmetic defects on the face), which negatively affect child’s physical and psycho-emotional development. Recently, fat transplantation efficacy has been studied as it can restore the volume and improve skin quality. This article presents the results of such surgery in a patient (15 years old) with linear form of LS.
QUALITY CONTROL OF HIGHLY SPECIALIZED WORKS DURING CONSTRUCTION
Authors:   Ural Federal University, Yekaterinburg, Russia, Vasilev A. V. , Yamov V. I. ,   Ural Federal University, Yekaterinburg, Russia
Published: November 2022

The article is devoted to the organization of quality control of highly specialized work on construction sites. The need to use new methods of quality control during construction is identified and justified. Special attention is paid to the shortcomings of the existing methods and tools of quality control. The main advantage of the new control method is the simplicity of organizing quality control of highly specialized works.
NUMERICAL ANALYSES OF UNDERGROUND OPENINGS IN COMPETENT ROCK MASSES: CONTINUOUS VS DISCONTINUOUS
Authors:   University of Pisa, Pisa, Italy, Pierotti A. , Leoni M. ,   WeSI Geotecnica, Genoa, Italy, Lo Presti D. ,   University of Pisa, Pisa, Italy
Published: November 2022

The paper is aimed at comparing the results of numerical analyses of underground openings in competent rock masses like the Carrara Marble (Italy) by considering a real and well documented case study. More specifically, 3D FEM and DEM analyses were carried out on a rock-mass model interested by two faults and three sets of discontinuities. The geometrical model is representative of deep underground openings where spalling - cracks and rock bursts can occur. PLAXIS 3D and 3DEC were used for the analyses. Intact rock and rock mass characterization of Carrara Marble was inferred from available technical literature. The analysis results were compared in terms of principal stresses and displacements in a number of monitoring points around the opening. The main practical interest is to find out a reliable approach for evaluating the stability of very large openings in a competent rock mass like Carrara marble. For such a purpose, a number of available in-situ stress measurements were used.
ANALYZING DOMINO EFFECTS OCCURRING ON GASOLINE STORAGE TANKS AT THE BULK OIL STORAGE AND TRANSPORTATION (BOST) DEPOT
Authors:   Ural Federal University, Yekaterinburg, Russia, MacCarthy G. A. K. , Asamoah C. N. ,   McGill University, Montreal, Canada, Ephraim B. A. ,   Science and Engineering Centre “Reliability and Safety of Large Systems and Machines”, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia,   Ural Federal University, Ekaterinburg, Russia, Alekhin V. N. ,   Ural Federal University, Ekaterinburg, Russia, Poluyan L. V. ,   Ural Federal University, Ekaterinburg, Russia
Published: November 2022

Since processed crude oil products are very vulnerable (susceptible) and highly flammable to cause massive catastrophes, such as fire and explosion, which are frequent and can create a chain reaction (Domino effects). This research was carried out at the Bulk Oil Storage and Transportation LTD depot on the Accra plain in Ghana where gasoline and Gasoil are stored. The research was conducted on a flammable gasoline area subjected to a vapor cloud explosion and the hazardous zone. Analyzing domino effects, propagation of a gasoline flammable vapor cloud caused by the explosion, ALOHA (Areal Location of Hazardous Atmospheres) software was used to find out how to apply effective safety measures to prevent future risks at any BOST facilities across the country. After the analysis, it was realized that 5.0 miles to the west-south-west the fuel concentration in the air was 2100 ppm lower than the explosive limit (LEL), and could not be as severe as that at 2.3 miles distance from the source point (12600 ppm LEL) with a greater fuel concentration in the atmosphere. The results made available would be useful in maximizing (improving) safety at the facility, residential area, and as well as minimizing future incidents.
PROBLEMS OF ENSURING OF THE EDUCATIONAL PROCESS IN ARCHITECTURE, ENGINEERING AND CONSTRUCTION BY ELECTRONIC RESOURCES PEDAGOGICAL PURPOSE
Authors:   Ural Federal University, Yekaterinburg, Russia, Mironova L. , Pastuhova L. ,   Ural Federal University, Yekaterinburg, Russia
Published: November 2022

The article deals with the stage of digitalization of education, which requires the development of information and educational environment (IEE) of universities (including architectural and construction profile), which is understood as a set of conditions for the interaction of all categories of users (students, teachers, parents, administration of educational institutions, the public concerned) with information and methodological support of the educational process on the basis of the information system of the educational organization. The main component of IEE is new electronic resources for educational purposes. The approach within which these resources will be developed by students — future programmers within interdisciplinary design under the leadership of the skilled teachers and the methodologists who are a part of interdepartmental scientific collectives is offered. The proposed approach is aimed at improving students’ professional competencies in the field of programming, the development of information and educational environment of the University, which is declared by the state regulations, as well as the implementation of the social order of the society on the formation of information and communication competence of the modern user in any sphere of public production and private life.
Getting to “No” You
Authors: Rafieyan Roia
Published: November 2022

Nonspeaking autistic people frequently begin music therapy at the request of others. Typically, family or care systems are tasked with making decisions on their behalf and have decided this service will be of benefit. Consequently, music therapy is a given rather than a choice. For this paper I have used my own evolving understanding to explore the complexities and power dynamics related to nonspeaking people being able to say “no” to music therapy. Elements in this discussion include: (a) the ability, and safety, to say “no” in the context of a culture of compliance, (b) the complicated relationship between music therapists and the systems within which they work, and how this affects the therapy relationship, and (c) the role of music therapy practice standards. I advocate the following: (1) presume competence, (2) enter the therapy space with curiosity and openness, (3) be willing to “get to know,” (4) coping skills or communication attempts are not “behavior” in need of correction, and (5) learn how each nonspeaking person communicates “no.” Actively encouraging and respecting treatment refusal goes a long way toward building a respectful music therapy practice/relationship.
Therapy – the Problematic Word in Music Therapy with Adolescents in the Child Welfare Services
Authors: Fuhr Gisle , Stensæth Karette
Published: November 2022

The word ‘therapy’ is known to be a challenging one in music therapy. This discourse-oriented study asks: how do a group of adolescents and their music therapists in the child welfare services relate to the word ‘therapy,’ and how can music therapy as a profession get round problems connected to the use of it? The data consists of case study material from collaborative interviews of six Norwegian adolescents in out-of-home care and their music therapists in the first author’s ongoing PhD study. Systematic text condensation is used to collect relevant meaning-bearing citations for further discussion and in-depth reflection. The findings show that the word ‘therapy’ creates profoundly negative associations among the informants. In fact, it creates so many difficulties that we actually question if ‘music therapy’ is a fitting label at all. However, because it seems unlikely and even unwise to develop new labels of the well-established ‘music therapy,’ we suggest starting the process of redefining it within the field of child welfare services by engaging in an active and systematic dialogue among all involved.
Against Cure and Toward Access in Musical Engagement
Authors: Ban Stephanie
Published: November 2022

In this paper, I reflect on my own experiences undergoing occupational therapy with musical elements in the United States in childhood for impairments related to physical coordination and visual processing. Although therapy involving music was by far the most enjoyable and least painful of the therapies and treatments I underwent as a multiply-disabled child, it was still anchored in the language of removing my impairments and/or aligning me better with nondisabled norms. I build on the work of Robert Gross (incorporating the social model of disability into music therapy) and Emily Elaine Williams (the participatory model of accommodation enabling music for pleasure, not for therapy). I also draw on works in the autistic and cross-disability online spheres on the overmedicalization of disabled people’s leisure activities to argue that framing music as a possible agent of cure or normalization harmfully obscures the ways in which music can provide access and mitigate impairments when directed and controlled by the listener, rather than by the therapist. My paper will also contrast music as therapy (imposed by others) vs. music as access tool (self-imposed) via a playlist and corresponding analysis. Music is central to my overall engagement with the world, affecting everything from processing and describing emotions, to communicating, to aiding in sensory processing. By introducing music as an access tool, or even as a form of assistive technology, I aim to challenge the dominant framing of normalization in therapy involving music and shift the focus to affirming disabled ways of engaging with music.
Un-Labelling the Language
Authors: Power Nicki , Millard Emma , The Lawnmowers Independent Theater Company Activists and Artists at , Carr Catherine
Published: November 2022

People with learning disabilities are often excluded from society. This is changing; however, discrimination persists. Language is one way in which people can be excluded. In healthcare and research, the use of labels and jargon can be a barrier to inclusion. A group of artist-researchers from the UK, some with learning disabilities and some without, wanted to explore power and language in the lives of people with learning disabilities. The group included social change activists The Lawnmowers Independent Theatre Company - who identify as having learning disabilities, and arts therapist researchers working in the National Health Service (NHS). Using arts-based participatory action research methods, we held two co-produced workshops. The first, explore power, jargon and labels for people with learning disabilities and the second, with the arts therapists only, deepened our understanding of exclusion. We used a range of arts-based approaches including improvised performance and music, reflective art making and poetry writing. This article describes the process of working together and how the arts helped us to connect and explore challenging issues. We discuss the different ways labels impact who we are and the power they have to include or exclude people with learning disabilities from healthcare and research. Our participatory approach supported multifaceted knowledge to emerge, which both empowered participants and laid foundations for an ongoing social change partnership. We share our recommendations to make research and healthcare more accessible for people with learning disabilities.
Wie gesellschaftliche Normen und Machtverhältnisse durch Sprache vermittelt werden
Authors: Fent Julia
Published: November 2022

In diesem Artikel umreiße ich zunächst mein Dissertationsprojekt, in welchem ich eine Analyse deutschsprachiger musiktherapeutischer Diskurse aus einer diskriminierungs-kritischen Perspektive vornahm. Dies geschah im Rahmen einer partizipativen Forschungsgruppe zusammen mit anderen Musiktherapeut:innen und durch die Analyse von Musiktherapie-Lehrbüchern. Theoretische Bezüge lieferten hierbei der Ansatz der Intersektionalität und Queer Theory, deren diskriminierungskritisches Potenzial ich kurz skizzieren werde. In der Beschreibung meines Vorgehens bei der Textanalyse und der Vorstellung der Ergebnisse werde ich Aspekte wie Wertungen, Ausschlüsse und Othering und deren sprachliche Erscheinungsformen aufzeigen. Parallel dazu werde ich auf der Grundlage meiner Erkenntnisse Vorschläge machen, wie anti-diskriminatorische Bemühungen in der Musiktherapie durch die kritische Reflexion der geschriebenen sowie der gesprochenen Sprache und entsprechende Veränderungen derselben unterstützt werden können.
the Preternatural Role of Man's Best Friend: An Explanatory Study on Boylan's Good Boy
Authors: Monisha M.
Published: November 2022

Jennifer Finney Boylan is an American trans woman, activist, television personality, author of several books and also a professor. She came out as trans in her 40's when she felt being estranged in the wrong body. The identity of trans people is always a crucial one. They constantly
face many obstacles and they are pushed outside the margins, prejudiced not just in their family, society, but everywhere they go. Boylan transitioned after getting married and becoming father of two children. She managed to be both dad and mother to her children. She says, "When you come
out with the truth, no matter how humiliating its revelation might be, you couldn't be punished for it". Boylan's Good Boy: My Life in Seven Dogs is a memoir about seven different dogs she loved during the seven phases of her life. Being a trans has been a burden and a gift in her life.
Even when she wanted to transition to live in her true self, she was forced to think thrice because she didn't want her family and close ones to suffer because of her. The canines she owned were a mixed bunch both in appearance and personality, and Jennifer tells about their dispositions,
behavior, and thoughts. This present paper deals with how Boylan's love for her dogs she owned, helped shape her life and allowed her to accept herself. It also explains how these dogs became part of her during her crucial moments of growth and transformation from young boy Jimmy Boylan
to a middle-aged woman Jennifer Finney Boylan.
Study on cosmic evolution and dynamics of a flat FLRW matter-dominated universe with a specified form of dynamical Cosmological Constant term
Authors: Nandi Tanmay , Choudhuri Amitava
Published: November 2022

We have investigated a cosmological model of matter-dominated universe with a specified form of dynamic cosmological Λ-term, varying as Λ = lH + (l + λ) H2 + ½ηρ where l, λ and η are constants.
We study the aforesaid cosmological model as an explanation for the accelerated expansion of the universe and obtain constraints on various model parameters for the estimation of the present values of cosmological parameters e.g.deceleration parameter, equation of state parameter, age of the
universe. We also investigate the statefinder parameter {r, s}. In order to investigate stability of the system, we have treated the system in terms of dynamical system theory and studied dynamical properties and investigated critical points. By performing corresponding critical points
analysis we have investigated different eras in the course of evolution of the universe.
A-MHA*: Anytime Multi-Heuristic A*
Authors: Natarajan Ramkumar , Saleem Muhammad , Aine Sandip , Likhachev Maxim , Choset Howie
Published: November 2022

Designing good heuristic functions for graph search requires adequate domain knowledge. It is often easy to design heuristics that perform well and correlate with the underlying true cost-to-go values in certain parts of the search space but these may not be admissible throughout the domain thereby affecting the optimality guarantees of the search. Bounded suboptimal search using several of such partially good but inadmissible heuristics was developed in Multi-Heuristic A* (MHA*). Although MHA* leverages multiple inadmissible heuristics to potentially generate a faster suboptimal solution, the original version does not improve the solution over time. It is an one shot algorithm that requires careful setting of inflation factors to obtain a desired one time solution. In this work, we tackle this issue by extending MHA* to an anytime version that finds a feasible suboptimal solution quickly and continually improve it until time runs out. Our work is inspired from the Anytime Repairing A* (ARA*) algorithm. We prove that our precise adaptation of ARA* concepts in the MHA* framework preserves the original suboptimal and completeness guarantees and enhances MHA* to perform in an anytime fashion. Furthermore, we report the performance of A-MHA* in 3-D path planning domain and sliding tiles puzzle and compare against MHA* and other anytime algorithms.
Generalized Target Assignment and Path Finding Using Answer Set Programming
Authors: Nguyen Van , Obermeier Philipp , Son Tran , Schaub Torsten , Yeoh William
Published: November 2022

In Multi-Agent Path Finding (MAPF), a team of agents needs to find collision-free paths from their starting locations to their respective targets. Combined Target Assignment and Path Finding (TAPF) extends MAPF by including the problem of assigning targets to agents as a precursor to the MAPF problem. A limitation of both models is their assumption that the number of agents and targets are equal, which is invalid in some applications. We address this limitation by generalizing TAPF to allow for (1) unequal number of agents and tasks; (2) tasks to have deadlines by which they must be completed; (3) ordering of groups of tasks to be completed; and (4) tasks that are composed of a sequence of checkpoints that must be visited in a specific order. Further, we model the problem using answer set programming (ASP) to show that customizing the desired variant of the problem is simple -- one only needs to choose the appropriate combination of ASP rules to enforce it. We also demonstrate experimentally that if problem specific information can be incorporated into the ASP encoding then ASP based methods can be efficient and can scale up to solve practical applications.
Learning to Generate Industrial SAT Instances
Authors: Wu Haoze , Ramanujan Raghuram
Published: November 2022

In this paper, we present Satgen, the first implicit generative model of real-world Boolean Satisfiability (SAT) formulas. Our approach uses unsupervised machine learning techniques to generate new formulas by mimicking the structural properties of a given input formula Phi. We proceed in two phases: first, we construct the Literal-Incidence Graph (LIG) of Phi. This is used by a Generative Adversarial Network (GAN) to generate new LIGs that exhibit graph-theoretic properties similar to those of the LIG of Phi. In the second phase, we extract a formula whose LIG would correspond to the generated graph. We show that generating such a formula is equivalent to finding a minimal clique edge cover of the given graph, which we tackle efficiently using a greedy hill-climbing algorithm. We verify experimentally that our approach generates formulas that closely resemble a given real-world SAT instance, as measured by a range of different metrics.
Guiding Search with Generalized Policies for Probabilistic Planning
Authors: Shen William , Trevizan Felipe , Toyer Sam , Thiebaux Sylvie , Xie Lexing
Published: November 2022

We examine techniques for combining generalized policies with search algorithms to exploit the strengths and overcome the weaknesses of each when solving probabilistic planning problems. The Action Schema Network (ASNet) is a recent contribution to planning that uses deep learning and neural networks to learn generalized policies for probabilistic planning problems. ASNets are well suited to problems where local knowledge of the environment can be exploited to improve performance, but may fail to generalize to problems they were not trained on. Monte-Carlo Tree Search (MCTS) is a forward-chaining state space search algorithm for optimal decision making which performs simulations to incrementally build a search tree and estimate the values of each state. Although MCTS can achieve state-of-the-art results when paired with domain-specific knowledge, without this knowledge, MCTS requires a large number of simulations in order to obtain reliable state-value estimates. By combining ASNets with MCTS, we are able to improve the capability of an ASNet to generalize beyond the distribution of problems it was trained on, as well as enhance the navigation of the search space by MCTS.
Multi-Train Path Finding
Authors: Atzmon Dor , Diei Amit , Rave Daniel
Published: November 2022

Multi-agent path finding (MAPF) is the problem of moving a set of agents from their individual start locations to their individual goal locations, without collisions. This problem has practical applications in video games, traffic control, robotics, and more. In MAPF we assume that agents occupy one location each time step. However, in real life some agents have different size or shape. Hence, a standard MAPF solution may be not suited in practice for some applications. In this paper, we describe a novel algorithm, based on the CBS algorithm, that finds a plan for moving a set of train-agents, i.e., agents that occupy a sequence of two or more locations, such as trains, buses, planes, or even snakes. We prove that our solution is optimal and show experimentally that indeed such a solution can be found. Finally, we explain how our solution can also apply to agents with any geometric shape.
Accent Strength in Lithuanian: Evidence from the Saussurean Accent Shift
Authors: Kushnir Yuriy
Published: November 2022

This paper investigates the distribution of surface accents in Lithuanian nominals based on data from Standard Lithuanian. Inflected nouns and adjectives in this language are subject to the following major accent rules: (a) the Basic Accentuation Principle (Halle & Vergnaud 1987a; b); (b) the Saussurean Accent Shift (Blevins 1993, Ambrazas 2006). I argue that one can account for both in a system where underlying lexical accents can vary in strength. This approach provides advantages compared to the analysis presented in Blevins (1993). For instance, in order to determine the placement of the accent within a weak stem, one does not have to resort to extraprosodicity or floating tones, thanks to a weak accent being present in the UR. The Saussurean Accent Shift, for which Blevins’s paper accounts only partially (see Section 5), is analyzed as an edge effect whereby a clash of two underlying accents at the right edge of a prosodic word results in the surface accent being right-aligned.
Perceptual Sensitivity to Stress in Native English Speakers Learning Spanish as a Second Language
Authors: Ortín Ramsés , Simonet Miquel
Published: November 2022

Second language (L2) learners of Spanish whose first language (L1) is English tend to find Spanish lexical stress patterns difficult to acquire. This study investigates whether such difficulty derives, at least in part, from an obstacle encountered during perceptual processing: reduced perceptual sensitivity to stress distinctions. Participants were adult L1 English L2 Spanish learners of various proficiency levels. The experiment was a categorical matching task with triads of auditory stimuli minimally contrasting in stress (target) or segmental composition (baseline), an ABX task. The results show that learners were more accurate in the baseline condition than in the target condition, suggesting reduced perceptual sensitivity to stress relative to other contrasts. The reduction in accuracy, however, was restricted to trials in which matching items were not adjacent, further suggesting an obstacle with phonological processing in working memory rather than perceptual categorization. The default stress processing routines of L1 English L2 Spanish learners, optimized for their L1 (not their L2), may be responsible for the acquisitional obstacles with this feature of the Spanish language.
Influence of Particle Size and Xylanase Pretreatment of Proso Millet Bran on Physical, Sensory and Nutritive Features of Gluten-Free Bread
Authors: Novotni Dubravka , Nanjara Ljiljana , Štrkalj Lucija , Drakula Saša , Čukelj Mustač Nikolina , Voučko Bojana , Ćurić Duška
Published: November 2022

Research background. Millet bran is a by-product rich in dietary fibre, micronutrients
and bioactive compounds which are often deficient in a gluten-free diet. Previously, cryogenic grinding has been shown to improve the functionality of bran to some extent, although it offered limited benefits for bread making. This study aims to investigate the effects of adding proso millet bran depending on its particle size and xylanase pretreatment on the physicochemical, sensory and nutritional properties of gluten-free pan bread.
Experimental approach. Coarse bran (d50=223 μm) was ground to medium size (d50=157
μm) using an ultracentrifugal mill or to superfine particles (d50=8 μm) using a cryomill. Millet bran presoaked in water (for 16 h at 55 °C) with or without the addition of fungal xylanase (10 U/g) replaced 10 % of the rice flour in the control bread. Bread specific volume, crumb texture, colour and viscosity were measured instrumentally. Along with proximate composition, the content of soluble and insoluble fibre, total phenolic compounds (TPC) and phenolic acids as well as total and bioaccessible minerals of bread were assessed. Sensory analysis of the bread samples included a descriptive, hedonic and ranking test.
Results and conclusions. Dietary fibre content (7.3–8.6 g/100 g) and TPC (42–57 mg/100
g) on dry mass basis of the bread loaves depended on bran particle size and xylanase pretreatment. The effect of xylanase pretreatment was most evident in the loaves with medium bran size in terms of higher content of fibre soluble in ethanol (45 %) and free ferulic acid content (5 %), improved bread volume (6 %), crumb softness (16 %) and elasticity (7 %), but lower chewiness (15 %) and viscosity (20–32 %). Bread bitterness and dark colour were increased after adding medium-sized bran but its bitter aftertaste, crust crookedness, crumb hardness and graininess were reduced with xylanase pretreatment. Although bran addition impaired protein digestibility, it enriched the bread with iron (341 %), magnesium (74 %), copper (56 %) and zinc (7.5 %). Xylanase pretreatment of the bran resulted in the improved bioaccessibility of zinc and copper of the enriched bread compared to the control and bread without xylanase.
Novelty and scientific contribution. Application of xylanase to medium sized bran obtained by ultracentrifugal grinding was more successful than its application to superfine bran obtained by the multistage cryogrinding as it resulted in more soluble fibre in gluten-free bread. Moreover, xylanase was proven beneficial in maintaining desirable bread sensory properties and mineral bioaccessibility.
PROSPECTS FOR BROWN ALGAE FUCUS DISTICHUS USE IN FISHMEAL PRODUCTS TECHNOLOGY
Authors:   Kamchatka State Technical University, Blagonravova M.V.
Published: November 2022

The research results on the development of fishmeal products technology with the introduction of brown Fucus distichus as well as a broth prepared from chum salmon dressing waste as structure-regulating, flavoring and enriching components are presented in the article. The study results of Fucus algae introduction influence on limiting shear stress, stickiness and water-holding capacity of minced fish and the effect results of replacing water with broth in the dough recipe are presented. It is shown that the introduction of these additives has a positive effect on the rheological properties of fishmeal products, increasing the strength of minced meat, reducing moisture losses during heat treatment, increasing the dough elasticity for dumpling production. The technological scheme of production, including operations for the introduction of algae and fish broth, is given.
AGROCHEMICAL AND MICROBIOLOGICAL PROPERTIES OF BARZASSKY PROCESSING FACTORY ROCK DUMP SOILS
Authors:   Kemerovo State University, Serazetdinova Y.R. , Dyshlyuk L.S. ,   Kemerovo State University, Fotina N.V. ,   Kemerovo State University, Osintseva M.A. ,   Kemerovo State University, Golubtsova Yu.V. ,   Kemerovo State University
Published: November 2022

The Barzassky district of the Kemerovo region is poorly developed by industry, but large areas of land are already subject to alienation. For the competent implementation of the process of disturbed territories recultivation, it is important to understand the degree of degradation of soil covers. Therefore, the purpose of the work was to study the agrochemical and microbiological properties of Barzassky processing factory rock dump soils. In the course of the work, soil samples from the surface layer of the dump as well as from the borders of the railway protective forest belt were studied. The studied soils of the dump are classified as slightly alkaline (average pH 7.899). The soils selected from the railway protective forest belt were subjected to acidification. The samples showed a low content of nitrogen (ammonium and nitrate – <5.0 and <2.8 mg/kg, respectively). Significant content of salinization was found. It has been established that acidification of soils in technogenically disturbed territories leads to a soil microbiota disorder and an increase of conditionally pathogenic microorganisms in them.
Archival preservation of cell suspensions for scRNA-Seq v1
Authors: Mazutis Linas , Masilionis Ignas
Published: November 2022

The inability to archive cells for subsequent high-quality single-cell analysis has hampered the interrogation of complex sample collections, such as those derived from clinical cohorts. Here, we describe a procedure for freezing FACS-sorted live cells in preservation medium, followed by thawing for single-cell RNA-seq (scRNA-seq) applications. By employing FBS-free preservation medium (Bambanker), this protocol achieves greater than 80% cell viability after one freeze/thaw cycle. Traditional preservation methods freeze cells in growth medium supplemented with 10% DMSO and 20-40% FBS. Although FBS improves cells viability during freezing and thawing, it needs to be removed for scRNA-seq due its inhibition of reverse transcription. FBS removal is typically achieved by washing in 1X PBS buffer, leading to inadvertent cell loss and transcriptional changes. Absence of FBS in the preservation medium makes it possible to apply thawed cell suspension directly to the 10X Chromium platform, by adding cells directly into reverse transcriptase reaction mix without the need for washing or buffer exchange. This approach minimizes sample handling to generate rapid (2-3 min for thawing), robust outcomes that avoid cell death or noticeable changes in the transcriptome.
S1: Step-by-step-guide using image J in the work flow. v2
Authors: Kalke Paul
Published: November 2022

How to use ImageJ in our 3D-workflow from data manipulation, import, alignment, segmentation and export as OBJ-file.
NCBI submission protocol for SARS-CoV-2 wastewater data: SRA, BioSample, and BioProject v2
Authors: Timme Ruth
Published: November 2022

PURPOSE: This method was developed at the FDA’s Center for Food Safety and Applied Nutrition for GenomeTrakr Laboratories; however, this protocol was written to be broadly applicable for any wastewater sequence data submission to NCBI. This protocol covers the last step of making your data public at NCBI. Specifically, it provides the steps to establish a new NCBI submission environment for your laboratory, including the creation of new BioProject(s) and submission groups. Once these are step up, the protocol steps through the process for submitting raw reads to SRA and sample metadata to BioSample through the Submission portal. For new submitters, there's quite a bit of groundwork that needs to be established before a laboratory can start its first data submission. We recommend that one person in the laboratory take a few days to get everything set up in advance of when you expect to do your first data submission. If you need a pipeline for frequent or large volume submissions, follow Step 1 in this protocol to get your NCBI submission environment established, then contact gb-admin@ncbi.nlm.nih.gov to set up an account for submitting through the API. Version updates: V2: minor edits to the BioSample and SRA templates V3: Adapted the protocol to be more broadly applicable to submitters outside of FDA's wastewater project. Updates were also made to both metadata templates, including a new attribute to the SRA metadata template, called "enrichment_kit". V4: updates to BioSample and SRA templates: expanded picklists, addition of specimen processing attributes for including replicate info, and the removal of target_extract attribute for reporting level of target found in the sample. V5: includes guidance for submitting BioSamples with no linked sequence data. V6: Updated templates. BioSample: added picklist for PCR concentration units. SRA: added new quality control attributes. V7: SRA and BioSample template updates V8: SRA template updates. "Illumina COVIDSeq Assay" added to library_preparation_kit, "QIAseq DIRECT SARS-CoV-2 - Boosted" added to amplicon_PCR_primer_scheme, "low coverage of characteristic mutations" added to quality_control_issues. minor edits to the protocol are also included in this update. V9: Minor edits to generalize the protocol for broader usage. Picklist updates made to the BioSample and SRA templates.
S2: Step-by-step-guide using MeshLab in the work flow. v2
Authors: Kalke Paul
Published: November 2022

How to do data refinements like repair, smooth and simplification in MeshLab and export as -ply-file.
Discussion issues of national identity during the russian-ukrainian war in the 21st century
Authors:   National Academy of Sciences of Ukraine M. Rylskyi Institute for Art Studies, Folkloristics and Ethnology, Borysenko Valentyna
Published: November 2022

In the conditions of the Russian-Ukrainian full-scale war, the sense of national identity in Ukraine intensified. The majority of people who were indifferent to the self-determination of their nationality, after seeing the injustice, the beastly face of the aggressor, the suffering of innocent people, felt that they were a part of the entire Ukrainian community. The patriotic and responsible part of the population for their country and their children stood in line for the military commissariat. Individuals who, even in peacetime, felt antipathy towards everything Ukrainian, committed treason. During the war, there are complex processes of self-awareness, of one’s involvement in the main goal – victory over the enemy. At the same time, it is worth understanding the identity of those who brought this terrible war closer by promoting the values of the «russian world», which the state maniac of the neighboring country came to defend. Because if we do not put an end to the russification of Ukraine, then millions will pay with their lives.