bluuebunny/crossref_metadata_2025 huggingface dataset:
Safe University in the Omicron Era: An Adaptable and Adjustable Protocol for the Operation of Universities during Epidemics Caused by Airborne Viruses
Authors: Pappas Georgios , Wallace Manolis
Published: July 2022

In this work we present an updated version of “Safe University”, a protocol aimed to ensure the safe operation of academic institutions during the SARS-CoV-2 pandemic. The protocol is detailed, addressing all aspects of the actions that are required, ranging from controlled access to the university premises and tracking of immunity status to air quality provisions and organization of classes and teaching methods and more. A step-by-step guide and a sample timeline are included, to facilitate practical implementation. The protocol was first developed in the summer of 2021, when the Delta variant had first emerged but not yet dominated, with the aim to support the operation of Greek universities at the beginning of the 2021–2022 academic year. Since then, it has been updated to reflect the evolution of the virus and the pandemic, as well as the developments in the relevant scientific knowledge and additional monitoring, safeguarding and treatment tools that humanity now possesses. It has also been given a more generic form, making it suitable and adjustable for other countries and cultural/political environments as well as other respiratory viruses. With some additional adjustments, it can also be suitable to deal with epidemics from non-respiratory viruses that may arise in the future.
Is There a Place for Adjuvant Chemotherapy in the Treatment of Locally Advanced Cervical Cancer?
Authors: Čerina Dora , Boraska Jelavić Tihana , Buljubašić Franić Matea , Tomić Krešimir , Bajić Žarko , Vrdoljak Eduard
Published: July 2022

Findings on the efficacy of adjuvant chemotherapy (ACT) of locally advanced cervical cancer (LACC) after the concurrent chemoradiation (CCRT) therapy were inconsistent, and the OUTBACK trial was expected to shed some light regarding the topic. Its results on ACT in LACC were negative, with the conclusion of not to use it. The objective of this review was to present the inconsistencies of previous studies, along with the OUTBACK trial in more detail, and to rethink whether its results provide an unambiguous and definite answer to the optimal position of ACT in the treatment of LACC. To critically appraise the OUTBACK trial and understand the consequences of its results, we used only randomized controlled studies (RCTs) on ACT in LACC that have been included in high-quality systematic reviews and meta-analyses. We calculated the pooled prediction intervals using a random effects meta-analysis of all published randomized studies including the OUTBACK trial. After combining the OUTBACK trial with the results of four previous randomized trials, the pooled hazard ratio for overall survival benefit of CCRT + ACT was 0.95 (95% CI 0.75; 1.20). The pooled hazard ratio of the four previous trials was 1.00 (95% CI 0.69; 1.44). The OUTBACK trial improved the precision of the pooled estimate, but the clinical heterogeneity and the consequent prediction intervals are still very wide, and with 95% reliability, we can expect that if the new study, using a similar approach to the ACT, on a randomly selected patient population from the presented five trials is conducted, its hazard ratio for overall survival after ACT would be between 0.47 and 1.93. In conclusion, there is an absolute need for further research in order to optimally define the position of ACT in the treatment of LACC.
Cross-Cultural Adaptation and Psychometric Properties of the SF-8 Questionnaire in Tanzanian Swahili for Injury Population
Authors: Pestillo de Oliveira Leonardo , Malheiros Caruzzo Nayara , Sakita Francis , Mmbaga Blandina T. , Boshe Judith , Tupetz Anna , Staton Catherine A. , Nickenig Vissoci Joao Ricardo
Published: July 2022

Background: There is a lack of tools to screen for health-related quality of life (HRQoL) in acute injury patients, despite the critical need for having a good understanding of the characteristics of mental health during the rehabilitation process. The SF-8 instrument, a shorter version of the SF-36, is the most widely used patient-based assessment of HRQoL. The aim of this research is to adapt the psychometric properties of the SF-8 to Swahili. Methods: This study is a secondary data analysis of previously collected and psychometric evaluation of the culturally adapted and translated SF-8. A cross-cultural adaptation committee carried out the process of translation to provide validity evidence based on test content. Confirmatory factor analysis was used to test the internal structure-based evidence. The validity based on relation to other variables (discriminant evidence) was tested using polychoric correlation with PHQ-2 (Patient Health Questionnaire-2). The reliability was tested using Cronbach’s alpha, Omega McDonald, and Composite Reliability. Results: 1434 adults who suffered an acute injury and presented to the emergency department between April 2018 and August 2020 were included in the study. The instrument demonstrated language clarity and domain coherence, showing validity evidence based on test content. The CFA (Confirmatory Factor Analysis) analysis showed good fit indices for both models (one- and two-factor models) of the SF-8. The discriminant evidence showed that SF-8 scores correlate strongly with the PHQ-2 instrument. These results supported the validity evidence in relation to other variables. All analyses of reliability were considered adequate with values above 0.90 for both models of the SF-8. Conclusions: The results show that the SF-8 instrument can provide relevant information about the health-related quality of life of acute injury patients, and allow practitioners to gain a better understanding of mental health, improving the treatment and follow-up of injury patients within Tanzanian culture.
Simulating the Effects of Pesticides on Honey Bee (Apis mellifera L.) Colonies with BeePop+
Authors: Garber Kristina , DeGrandi-Hoffman Gloria , Curry Robert , Minucci Jeffrey M. , Dawson Daniel E. , Douglass Cameron , Milone Joseph P. , Purucker S. Thomas
Published: July 2022

The US Environmental Protection Agency (USEPA) employs a tiered process for assessing risks of pesticides to bees. The model discussed in this paper focuses on honey bees (Apis mellifera L.). If risks to honey bees are identified at the first tier based on exposure and toxicity data for individual adult and larval honey bees, then effects are evaluated in higher-tier studies using honey bee colonies. Colony-level studies require large amounts of resources (to conduct and review) and can yield data complicated by the inherent variability of colonies, which are influenced by factors that cannot readily be controlled, including weather, pests, diseases, available forage, and bee management practices. To better interpret these data, the USEPA and the US Department of Agriculture (USDA) developed a simulation model, BeePop+, that assesses potential honey bee colony-level effects of pesticides. Here, we describe this model using the population model guidance, use, interpretation, and development for ecological risk assessment (Pop-GUIDE) framework, which is a conceptual framework for the development and evaluation of population models. Within the context of Pop-GUIDE, BeePop+ is considered a “realistic-precise” model and reflects the inherent variability of colony response to pesticide exposure by simulating many outcomes. This model meets the desired features needed for use in pesticide risk assessments as its required data inputs are typically available, it is applicable to different US locations, and the outputs are both relevant to USEPA’s protection goals for honey bees and are consistent with the outcomes of empirical studies. This model has also been evaluated using available empirical colony-level data; however, additional evaluation with other studies may still be done in the future prior to completing implementation.
Digital Monitoring of Students’ Soft Skills Development as an Interactive Method of Foreign Language Learning
Authors: Medvedeva Olesya Dmitrievna , Rubtsova Anna Vladimirovna , Vilkova Anastasia Vladimirovna , Ischenko Varvara Vladimirovna
Published: July 2022

Nowadays, the curriculum of higher education is mainly based on hard skills development, although soft skills are of critical importance for successful academic and professional performance. Consequently, the purpose of the article is to describe the possible methods of mastering the second-year students’ soft skills within the scope of a foreign language course, using interactive methods. The aim of the research was to elaborate on three types of interactive problem-based tasks and assessment criteria which allow us to monitor the progress of soft skills such as problem solving, teamwork, leadership, time management and technology skills, and analytical and creative thinking. Both tasks and criteria were uploaded onto an online educational platform. The case study method, which was considered to be the main monitoring tool, turned out to be effective in the pedagogical experiment where the students collaborated both online and offline. The experiment demonstrated a positive trend in students’ soft skills improvement alongside their foreign language communication skills. Moreover, statistical analyses showed the effectiveness of the system created to master soft skills. The proposed system for digital monitoring of soft skills development can be useful for teaching personnel who want to make the educational process more interactive and productive for advancing students’ soft skills.
Validity of the Computerized Battery for Neuropsychological Evaluation of Children (BENCI) in Spanish Children: Preliminary Results
Authors: Fernández-Alcántara Manuel , Albaladejo-Blázquez Natalia , Fernández-Ávalos María Inmaculada , Sánchez-SanSegundo Miriam , Cruz-Quintana Francisco , Pérez-Martínez Vanesa , Carrasco-Sánchez Claudia , Pérez-Marfil María Nieves
Published: July 2022

Study of the neurodevelopment of children is vital to promote good quality of life during childhood. Few batteries showing adequate reliability and validity indices are available to evaluate the different neuropsychological domains. The objective of this study was to obtain initial evidence on the validity of the Computerized Battery for Neuropsychological Evaluation of Children (BENCI) in a Spanish population. To assess the validity of the BENCI battery and other measures of task switching, abstract reasoning, linguistic abilities, processing speed, and attention were used. The sample was composed of a total of 73 children aged 9, 10, and 11 years. Significant differences among age groups were observed in the domains of sustained attention, memory, and executive function. In addition, the BENCI subtests showed statistically significant correlations with the other neuropsychological tools. Further research is warranted on the relationship of the BENCI with other tests in wider age groups and to assess the factorial structure of the scale and the reliability values of the subtests. In conclusion, this study seems to indicate that the Spanish version of the BENCI has promising validity to be used for evaluating the main neuropsychological domains in children.
Prediction of Power Output from a Crystalline Silicon Photovoltaic Module with Repaired Cell-in-Hotspots
Authors: Lee Koo , Cho Sungbae , Yi Junsin , Chang Hyosik
Published: July 2022

Recycling of problematic photovoltaic modules as raw materials requires considerable energy. The technology to restore cells in hotspot modules at a relatively low cost is more economical than replacing them with new modules. Moreover, a technology that restores power by replacing a cell-in-hotspot of a photovoltaic module with a new cell rather than replacing the whole module is useful for operating power plants. In particular, power plants that receive government subsidies have to use certified modules of specific models; the modules cannot be replaced with other modules. Before putting resources into module restoration, predicting the power of a module to be restored by replacing a cracked cell with a new cell is essential. Therefore, in this study, the module output amount after restoration was calculated using the previously proposed relative power loss analysis method and the recently proposed cell-to-module factor analysis method. In addition, the long-term degradation coefficient of the initial cell and the loss due to the electrical mismatch between the initial and new cell were considered. The output of the initial cell was estimated by inversely calculating the cell-to-module factor. The differences between the power prediction value and the actual experimental result were 1.12% and 3.20% for samples 190 A and 190 B, respectively. When the initial rating power and tolerance of the module were corrected, the differences decreased to 0.10% and 2.01%, respectively. The positive mismatch, which restores cells with a higher power, has no loss due to the reverse current; thus, the efficiency of the modules is proportional to the average efficiency of each cell. In this experiment, the electrical mismatches were only 0.37% and 0.34%. This study confirmed that even if a replacement cell has a higher power (<20%) than the existing cell, the power loss is not significantly affected, and heat generation of the existing normal cell is not observed. Hence, it was concluded that when some cells are damaged in a crystalline solar cell, the module could be restored by replacing only those cells instead of disposing of the entire module. However, for commercialization of the proposed method, a long-term reliability test of the module repaired using this method must be performed to confirm the results. Following this, recycling cells instead of recycling modules will be an economical and eco-friendly alternative.
Morphology Control in Organic Solar Cells
Authors: Liang Qiuju , Lu Haodong , Chang Yinxia , He Zemin , Zhao Yuzhen , Liu Jiangang
Published: July 2022

Organic solar cells (OSCs) are a kind of device that can convert light energy into electrical energy, they possess the advantages of being lightweight, flexible, processable printing, and large-area production, and they are an effective way to alleviate energy deficiency and environmental pollution [...]
An Analytical Model for Wind Turbine Wakes under Pressure Gradient
Authors: Dar Arslan Salim , Porté-Agel Fernando
Published: July 2022

In this study, we present an analytical modeling framework for wind turbine wakes under an arbitrary pressure gradient imposed by the base flow. The model is based on the conservation of the streamwise momentum and self-similarity of the wake velocity deficit. It builds on the model proposed by Shamsoddin and Porté-Agel, which only accounted for the imposed pressure gradient in the far wake. The effect of the imposed pressure gradient on the near wake velocity is estimated by using Bernoulli’s equation. Using the estimated near wake velocity as the starting point, the model then solves an ordinary differential equation to compute the streamwise evolution of the maximum velocity deficit in the turbine far wake. The model is validated against experimental data of wind turbine wakes on escarpments of varying geometries. In addition, a comparison is performed with a pressure gradient model which only accounts for the imposed pressure gradient in the far wake, and with a model that does not account for any imposed pressure gradient. The new model is observed to agree well with the experimental data, and it outperforms the other two models tested in the study for all escarpment cases.
Power and Flow Analysis of Axial Induction Control in an Array of Model-Scale Wind Turbines
Authors: Houck Daniel , Cowen Edwin A.
Published: July 2022

As research on wind energy has progressed, it has broadened from a focus on the wind turbine to include the entire wind farm. In particular, methods to mitigate the negative effects of upstream wakes on downstream turbines have received significant attention. One such mitigation method is axial induction control (AIC) in which upstream turbines are derated to reduce the momentum deficits in their wakes, leaving higher speed flow for downstream turbines. If performed correctly, it is theorized that the power production gains in downstream turbines can compensate for the power sacrificed by derating upstream turbines. Previous work has indicated that the “excess” energy left in the wake of the derated turbine is along the edges of the wake such that a turbine placed directly downstream will see little to no increase in power. To address this hypothesis, we performed a control and treatment experiment with model-scale turbines in a wide flume. Five turbines were arranged in three successive streamwise rows, with the first two rows consisting of two aligned turbines, while three turbines with small transverse spacing were placed in the third row, the central of which was also streamwise-aligned with the upstream two turbines. This arrangement was used to evaluate the difference in power production primarily among the turbines in the third row when the upstream turbines were derated. Particle image velocimetry (PIV) was used to measure the wake in the streamwise-vertical planes along the centerline of the array and along the rotor tips of the centerline turbines between all rows, and high accuracy power measurements were recorded from each turbine. The results show that the total power of the array was decreased while implementing AIC but that individual turbine performance differed from predictions. PIV results show that mean kinetic energy (MKE) is redistributed to the edges of the wakes as has been previously hypothesized. We provide an analysis of the results that connects both the power and flow measurements and that highlights several of the aspects of wind turbine wake flows that make them so complex and challenging to study.
Toward Understanding Renewable Energy and Sustainable Development in Developing and Developed Economies: A Review
Authors: Said Rabie , Bhatti Muhammad Ishaq , Hunjra Ahmed Imran
Published: July 2022

In recent years, there has been an upsurge of studies on sustainable development. The majority of research focuses on developed countries and issues that are incompatible with developing nations. This study addresses a gap in the literature by reviewing the research on developed and developing economies, as well as their social and environmental boundaries, under the renewable energy and sustainable development (RESD) nexus. It also explores how RESD may be applied in extreme situations such as population increase, energy supply disruptions, and transportation shortfalls. The fundamental contribution of this paper is to provide detailed debate from the perspective of economic growth hypotheses and their relationship with energy usage and renewable energy solutions for sustainable growth and development.
Numerical Investigation on the Jet Characteristics and Combustion Process of an Active Prechamber Combustion System Fueled with Natural Gas
Authors: Xu Lina , Li Gang , Yao Mingfa , Zheng Zunqing , Wang Hu
Published: July 2022

An active prechamber turbulent ignition system is a forced ignition method for internal combustion engines fueled with low reactivity fuels, i.e., natural gas and gasoline, which could expand the lean-burn limit, promote flame propagation, and ensure cyclic stability. In the present study, the effects of charge concentration stratifications inside the prechamber on the jet characteristics and combustion process were numerically investigated using CONVERGE software coupled with a reduced methane mechanism by the coupling control of spark timing and prechamber global equivalence ratio. The results show that the jet characteristics and ignition mechanisms can be regulated by controlling the prechamber global equivalence ratio and spark timing. On the one hand, as the prechamber global equivalence ratio increases, the velocity of the jet increases firstly and then decreases, the temperature drops, and OH and CH2O radicals are reduced, but the stable combustion intermediates, CO and H2, are increased. Thus, the ignition mechanism changes from flame ignition (ignition by flame and reactive radicals) to jet ignition (ignition by hot combustion intermediates), and the ignition delay is shortened, but the combustion duration is extended, mainly due to more of the combustion intermediates, CO and H2, downstream of the jet. On the other hand, as spark timing is advanced, the jet velocity and the mass of the OH and CH2O radicals increase, which is conducive to flame ignition, and the ignition delay and combustion duration are reduced.
Bioenergy, Biofuels, Lipids and Pigments—Research Trends in the Use of Microalgae Grown in Photobioreactors
Authors: Borowiak Daniel , Krzywonos Małgorzata
Published: July 2022

This scientometric review and bibliometric analysis aimed to characterize trends in scientific research related to algae, photobioreactors and astaxanthin. Scientific articles published between 1995 and 2020 in the Web of Science and Scopus bibliographic databases were analyzed. The article presents the number of scientific articles in particular years and according to the publication type (e.g., articles, reviews and books). The most productive authors were selected in terms of the number of publications, the number of citations, the impact factor, affiliated research units and individual countries. Based on the number of keyword occurrences and a content analysis of 367 publications, seven leading areas of scientific interest (clusters) were identified: (1) techno-economic profitability of biofuels, bioenergy and pigment production in microalgae biorefineries, (2) the impact of the construction of photobioreactors and process parameters on the efficiency of microalgae cultivation, (3) strategies for increasing the amount of obtained lipids and obtaining biodiesel in Chlorella microalgae cultivation, (4) the production of astaxanthin on an industrial scale using Haematococcus microalgae, (5) the productivity of biomass and the use of alternative carbon sources in microalgae culture, (6) the effect of light and carbon dioxide conversion on biomass yield and (7) heterotrophy. Analysis revealed that topics closely related to bioenergy production and biofuels played a dominant role in scientific research. This publication indicates the directions and topics for future scientific research that should be carried out to successfully implement economically viable technology based on microalgae on an industrial scale.
Promoting the Diffusion of New Energy Vehicles under Dual Credit Policy: Asymmetric Competition and Cooperation in Complex Network
Authors: Yu Liukai , Jiang Xuehai , He Yujie , Jiao Yangyang
Published: July 2022

This study aims to investigate the impact of dual credit policy on the diffusion of new energy vehicles (NEVs) from the perspective of complex interactions among heterogeneous manufacturers. Thus, the market competition and credit cooperation relationships, constituting the complex interrelated system in NEV diffusion, are considered in this paper. To this end, we established a double-layer complex network to depict the asymmetric competition and cooperation structure, and developed an evolution game model on network, revealing the diffusion rule and trend of NEVs among manufacturers. Simulation results show that the existence of credit cooperation relationship can effectively improve the diffusion of NEVs, especially when implementing cooperative strategy that prioritizes helping manufacturers with low sale profits. Such a cooperative strategy is effective for maintaining high diffusion of NEVs even under low NEV credit’s trading price. Meanwhile, the monopoly competitive structure characterized by scale free is harmful to NEV diffusion. However, credit cooperation can eliminate the by-effect of monopoly structure greatly by adopting the strategy of distributing by sale profits. In addition, manufacturers are advised to learn from their competitors during the evolutionary process, which should be the focus of manufacturers to maximize the NEV diffusion under small world competitive structure.
Classification and Evaluation of Shale Oil Reservoirs of the Chang 71-2 Sub-Member in the Longdong Area
Authors: Gao Heting , Zhou Xinping , Wen Zhigang , Guo Wen , Tian Weichao , Li Shixiang , Fan Yunpeng , Luo Yushu
Published: July 2022

Establishing a suitable classification and evaluation scheme is crucial for sweet spot prediction and efficient development of shale oil in the Chang 71-2 sub-member of the Longdong area. In this paper, a series of experiments, such as casting thin sections (CTS), scanning electron microscopy (SEM), low-temperature nitrogen adsorption (LTNA), high-pressure mercury intrusion porosimetry (HMIP), and nuclear magnetic resonance (NMR), were integrated to classify the pore throats and shale oil reservoirs in the study area. Moreover, the pore structure characteristics of different types of reservoirs and their contributions to productivity were revealed. The results show that the pore-throat system can be divided into four parts: large pore throats (>0.2 μm), medium pore throats (0.08~0.2 μm), small pore throats (0.03~0.08 μm), and micropore throats (<0.03 μm). Based on the development degree of various pore throats, the reservoir is divided into four types: type I (Φ ≥ 10%, K > 0.1 mD), type II (Φ ≥ 8%, 0.05 mD < K < 0.1 mD), type III (Φ ≥ 5%, 0.02 mD < K < 0.05 mD) and type IV (Φ < 5% or K < 0.02 mD). From type I to IV reservoirs, the proportion of dissolved pores and intergranular pores gradually decreases, and the proportion of intercrystalline pores increases. The proportion of large pore throats gradually decreases, and the proportions of medium pore throats and small pore throats increase initially and then decrease, while the proportion of micropore throats increases successively. The NMR pore size distribution changes from the right peak to the left peak. The developed section of the type I reservoir corresponds to the oil layer, and the developed section of the type I and II reservoirs corresponds to the poor oil layer. In contrast, the developed section of the type III and IV reservoirs corresponds to the dry layer. The daily production from single wells is primarily attributable to type I and II reservoirs.
Progressive Intercalation and Exfoliation of Clay in Polyaniline–Montmorillonite Clay Nanocomposites and Implication to Nanocomposite Impedance
Authors: Zhu Yanrong , Kottarath Sandeep , Iroh Jude O. , Vaia Richard A.
Published: July 2022

Conducting polymers, such as polyaniline (PANi) and polypyrrole (PPy), and their nanocomposites, are desired in a wide range of applications, including supercapacitors, lithium ion battery, chemical sensors, biosensors, barrier thin films, and coatings, because of their interesting electrical and electrochemical properties. It is well known that the properties of polymer nanocomposites depend on their chemical structure, as well as their microstructure, yet scientists and engineers have not fully understood how to properly control the structure of polymer nanocomposites. In this study, it is shown that the structure of polyaniline–montmorillonite clay nanocomposites (PACN) can be controlled by varying the ammonium persulfate (APS, oxidant) concentration. The structure of polyaniline and Cloisite 20A clay are, therefore, profoundly affected during the synthesis of PACN nanocomposites. The thickness of polyaniline crystal decreased with increasing oxidant concentration. Fourier transform infrared spectroscopy (FTIR) was used to determine the oxidation state of PANi. The structure of the nanocomposites was studied by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), wide-angle X-ray diffraction (WAXD), wide-angle X-ray scattering (WAXS), and small-angle X-ray scattering (SAXS). Electrochemical impedance spectroscopy (EIS) analysis of polyimide nanocomposite coatings containing PACN with varying levels of intercalation and exfoliation indicate that the coating impedance decreased with exposure time for some coating systems. It is shown that polyimide–PACN nanocomposite coating containing highly intercalated clay was more durable and maintained constant impedance after 20 weeks of exposure in a corrosive medium.
The Feasibility of Producing Particleboards with Waste Wood from Civil Construction and Epoxidized Waste Cooking Oils
Authors: Cavalcanti Washington Moreira , de Oliveira Leandro Soares , Maziero Rômulo , Campos Rubio Juan Carlos
Published: July 2022

The feasibility of using epoxidized waste cooking oils as a partial replacement for synthetic resins in the manufacture of lignocellulosic composites where the reinforcement is comprised of mechanically ground wood from civil construction waste wood (CCWW) was investigated. For this study, the wood-epoxy composite was prepared using the thermo-curing technique, and wood particle contents of 20 and 30% (m/m) were studied with a matrix comprised of 50% epoxidized vegetable oil and 50% petroleum-based epoxy resin. The specific mass of the composites was in the range of 1130 to 1380 kg/m3, with the lowest value for the highest content of wood particles. Fourier transform infrared spectroscopy was successfully used to monitor the epoxidation of the vegetable oils and the subsequent curing of the epoxy resins and particleboards. Thermal stability of the composite was dictated by its lignocellulosic content, and significant mass losses occurred at temperatures higher than 300 °C, regardless of the wood particles content. The introduction of CCWW particles into the polymeric matrices did not promote the desired effect of improving the mechanical properties in regard to those of the cured blend of epoxy resins. However, the produced particleboards still met the standards of the American National Standards for general purpose boards in regard to their physical and mechanical properties (e.g., density, tensile strength). Hence, the use of wood waste and waste cooking oil to produce particleboards was deemed justified within the framework of a cascading lifecycle-extended service for both wastes.
Evaluation of Thermal Degradation of Tropane and Opium Alkaloids in Gluten-Free Corn Breadsticks Samples Contaminated with Stramonium Seeds and Baked with Poppy Seeds under Different Conditions
Authors: Vera-Baquero Fernando L. , Morante-Zarcero Sonia , Sierra Isabel
Published: July 2022

In this work, the thermal degradation of tropane and opium alkaloids was studied in samples of breadsticks prepared with corn flour, contaminated with seeds of Datura stramonium, and containing seeds of Papaver somniferum L. A total of seven different samples were prepared and eight alkaloids were studied, three tropane (atropine, scopolamine, and anisodamine) and five opium (morphine, codeine, thebaine, papaverine, and noscapine) alkaloids. For this purpose, a fast, easy and efficient method based on solid-liquid extraction (SLE) prior to the analysis by high-performance liquid chromatography with a diode array detector (HPLC-DAD) was developed and validated. Thermal degradation studies showed a decrease in the TAs and OAs content under baking (180 °C for 20 min) that was between 7–65% for atropine, depending on the preparation conditions used, between 35–49% for scopolamine and anisodamine, up to 100% for morphine and codeine and between 14–58% for thebaine, papaverine, and noscapine. Results also evidenced that degradation of morphine and codeine was higher when the seeds were added as topping to the breadsticks.
Effect of Gelled Emulsions Elaborated with Soybean Oil, Maca (Lepidium meyenni) Flour, and Chincho (Tagetes elliptica Sm.) Essential Oil upon Animal Fat Substitution in Beef Burgers
Authors: Cerrón-Mercado Francis , Botella-Martínez Carmen M. , Salvá-Ruíz Bettit K. , Fernández-López Juana , Pérez-Alvarez Jose A. , Viuda-Martos Manuel
Published: July 2022

The aim of this study was to analyze the effect of pork backfat (PB) substitution in a meat burger with a gelled emulsion (GE) elaborated with maca flour, soybean oil, and chincho essential oil (CEO). Lipid profile (gas chromatography—GC), health indices, physicochemical properties (CIELAB color, pH, texture profile—TPA), and cooking and sensory characteristics of meat burgers were analyzed. Five formulations were evaluated: control (BC) (80% beef meat and 20% PB); BSM (10% PB + 10% GE); BSMC0.25 (BSM + 0.25% CEO); BSMC0.5 (BSM + 0.5% CEO), and BSMC1.0 (BSM + 1.0% CEO). GE substitution in meat burgers provided a healthier lipid profile; the amount of SFA was reduced (p < 0.05), while PUFA content was significantly increased (p < 0.05). Furthermore, the use of GE resulted in healthier PUFA/SFA ratios and lower atherogenic and thrombogenic indices. The addition of GE increased moisture content and decreased fat and protein contents. Color parameters (L*, b*, and C*) decreased after cooking. Hardness (p < 0.05), cooking losses, and shrinkage changes decreased with GE addition. Lipid oxidation levels were significantly (p < 0.05) affected by GE substitution. Therefore, the substitution of PB by GE can be considered as an effective strategy to produce healthier meat burgers without negatively affecting their physicochemical and technological properties.
Effects of Harvest Maturity on the Fruit Quality of Different Flesh-Type Peach Stored at Near-Freezing Point Temperature
Authors: Zhang Binbin , Chen Xingxing , Wang Na , Guo Shaolei , Jiang Weibing , Yu Mingliang , Ma Ruijuan
Published: July 2022

To investigate the peach fruit flesh types (soft-melting, hard-melting, stonyhard and non-melting) and harvest maturity level suitable for near-freezing temperature storage (NFTS), eight peach cultivars that had four flesh types were used as test materials. Changes in fruit respiration intensity and ethylene release rates, as well as the differences in quality indexes, such as soluble solids content (SSC), firmness, color difference, pigment content, soluble sugar and organic acid component content, of three fruit maturity levels (70%, 80% and 90% maturity) under NFTS conditions were analyzed and compared. The fruit quality indexes of peach having different maturity levels and flesh types changed little during NFTS. The SSC and total sugar content of hard-melting and stonyhard peach fruit were higher than those of other flesh types during NFTS. Those fruit maintained greater firmness at the end of the storage period. The differences in respiration intensity and ethylene release rate were small, but for fruit coloring, hard-melting fruit performed better than stonyhard fruit. The 80%, compared with the 90%, maturity stage maintained more fruit moisture, had less fruit mass loss and maintained a greater edible firmness. It effectively impeded the fruit senescence process and was the most suitable maturity for NFTS. Thus, the hard-melting peach maintained the highest commercial value and desirable storage characteristics under NFTS conditions, and its 80% maturity level was the most suitable for NFTS.
Physicochemical Properties, Stability and Texture of Soybean-Oil-Body-Substituted Low-Fat Mayonnaise: Effects of Thickeners and Storage Temperatures
Authors: Wang Wan , Hu Chuanbing , Sun Hong , Zhao Jiale , Xu Cong , Ma Yue , Ma Jiage , Jiang Lianzhou , Hou Juncai
Published: July 2022

With the increasing consumer demand for low-fat and low-cholesterol foods, low-fat mayonnaise prepared from soybean oil body (SOB) substitute for egg yolk has great consumption potential. However, based on previous studies, it was found that the stability and sensory properties of mayonnaise substituted with SOB were affected due to there being less lecithin and SOB containing more water. Therefore, this study investigated the effects of different ratios of xanthan gum, pectin and modified starch as stabilizers on the apparent viscosity, stability, texture and microstructure of SOB-substituted mayonnaise. It was found that the apparent viscosity and stability of SOB-substituted mayonnaise increased significantly when xanthan gum, pectin and modified starch were added in a ratio of 2:1:1. Meanwhile, the emulsified oil droplets of SOB-substituted mayonnaise were similar in size and uniformly dispersed in the emulsion system with different thickener formulations. In addition, the storage stability of SOB-substituted mayonnaise was explored. Compared with full egg yolk mayonnaise, SOB-substituted mayonnaise had better oxidative stability and bacteriostatic, which is important for the storage of mayonnaise. This study provided a theoretical basis for the food industry application of SOB. Meanwhile, this study provided new ideas for the development and storage of low-fat mayonnaise.
Ingredients and Process Affect the Structural Quality of Recombinant Plant-Based Meat Alternatives and Their Components
Authors: Zhao Di , Huang Lu , Li He , Ren Yuqing , Cao Jinnuo , Zhang Tianyu , Liu Xinqi
Published: July 2022

Recombinant plant-based meat alternatives are a kind of product that simulates animal meat with complete structure by assembling plant-tissue protein and other plant-based ingredients. The market is growing rapidly and appears to have a promising future due to the broad culinary applicability of such products. Based on the analysis and summary of the relevant literature in the recent five years, this review summarizes the effects of raw materials and production methods on the structure and quality of specific components (tissue protein and simulated fat) in plant-based meat alternatives. Furthermore, the important roles of tissue and simulated fat as the main components of recombinant plant-based meat alternatives are further elucidated herein. In this paper, the factors affecting the structure and quality of plant-based meat alternatives are analyzed from part to whole, with the aim of contributing to the structural optimization and providing reference for the future development of the plant meat industry.
Attenuation of the Acoustic Activity in Cement Beams under Constant Bending Load Closely Approaching the Fracture Load
Authors: Triantis Dimos , Loukidis Andronikos , Stavrakas Ilias , Pasiou Ermioni D. , Kourkoulis Stavros K.
Published: July 2022

The acoustic activity in beam-shaped specimens made of cement is studied, assuming that the beams are loaded in three-point bending under a step-wise loading scheme. Attention is focused to the attenuation of the acoustic activity during the constant-load stage of each specific loading step. The experimental data are analyzed in terms of the interevent time intervals between any two successive acoustic hits (using the F-function concept) and, further, in terms of the power of the acoustic hits (in terms of the recently introduced P-function). It is indicated that while the mechanical load is kept constant, the acoustic activity attenuates steadily, and during the early steps of this attenuation phase, the temporal evolution of both the F- and P-functions is excellently described by an exponential law. Moreover, it is proven that for both the F- and P-functions, the relaxation exponents decrease monotonically with increasing load. This decrease becomes quite abrupt for loads exceeding about 80% of the fracture load, providing an interesting and promising pre-failure indicator, i.e., a warning signal that the specimen is entering into the stage of impending macroscopic fracture. The specific conclusions are in very satisfactory agreement, both qualitatively and quantitatively, with similar ones drawn by considering the temporal evolution of the respective b-value.
Asymptotic and Robust Stabilization Control for the Whole Class of Fractional-Order Gene Regulation Networks with Time Delays
Authors: Li Zitong , Zhang Zhe , Liao Qiong , Rong Mingqiang
Published: July 2022

Throughout this article, a novel control strategy for fractional-order gene regulation networks (FOGRN) of all categories is designed by using the vector Lyapunov function in combination with the M-matrix measure. Firstly, a series of puzzles surrounding the asymptotic stability of two-dimensional FOGRN are studied, and a new asymptotic stability control strategy is formulated based on the vector Lyapunov function in combination with the M-matrix measure, ensuring that the controlled FOGRN has a strong robust stability. In addition, the corresponding asymptotic stability criterion is deduced. On this basis, the problem of asymptotic stability of a three-dimensional FOGRN is studied. Based on the new method, a stabilization control strategy is also formulated with the corresponding asymptotic stability criterion deduced, ensuring that the controlled FOGRN has a strong robust stability as well. Finally, this novel method’s effectiveness and generality are authenticated via simulation experiments.
The Pharmacogenetics of Treatment with Quetiapine
Authors: Ortega-Ruiz María , Soria-Chacartegui Paula , Villapalos-García Gonzalo , Abad-Santos Francisco , Zubiaur Pablo
Published: July 2022

Quetiapine is a second-generation antipsychotic used for the treatment of schizophrenia, depression and bipolar disorder. The aim of this traditional review was to summarize the available pharmacogenetic information on this drug and to conclude about its clinical relevance. For this purpose, bibliographic research was performed in the Pharmacogenomics Knowledge Base (PharmGKB) database. A total of 23 articles were initially retrieved, of which 15 were finally included. A total of 19 associations were observed between 15 genes, such as CYP3A4, CYP3A5, COMT or MC4R, and 29 clinical events. No associations were consistently replicated between pharmacogenetic biomarkers and clinical events, except for that between the CYP3A4 phenotype and quetiapine exposure, which was the only one considered clinically relevant. Consistently, the DPWG published a clinical guideline on this association, where dose adjustments for CYP3A4 poor metabolizers (PMs) are indicated to prevent the occurrence of adverse drug reactions (ADRs).
The Pattern of Substance Use among People Who Use Drugs (PWUD) Receiving Treatment at University Malaya Medical Centre (UMMC) during the COVID-19 Pandemic and the Associated Factors
Authors: Yahaya Amir Zulhilmi bin , Yee Anne , Sulaiman Ahmad Hatim
Published: July 2022

There was a change in the pattern of substance usage among people who use substances during the COVID-19 pandemic period. This study aims to determine the effects of the COVID-19 pandemic on the pattern of substance usage among people who use drugs (PWUD) receiving treatment at the University Malaya Medical Centre (UMMC) as well as levels of anxiety and depression together with coping mechanisms and the factors affecting the pattern of substance use during COVID-19 pandemic period. A cross-sectional study was applied. The questionnaire used was the Mini-European Web Survey on Drugs (EWSD): COVID-19, Hospital Anxiety and Depression Scale (HADS), and Brief COPE Scale. In total, 130 PWUD were recruited. Of the participants, 36.2% of PWUD had not used/stopped the usage of illicit drugs/alcohol, 26.2% increased their usage, 20% decreased, and 14.6% used the same amount of illicit substances/alcohol during the COVID-19 pandemic period/restrictions. In addition, 28.5% of PWUD had an increased intention to seek professional support for drug counseling/treatment during the COVID-19 pandemic period. The prevalence anxiety and depression symptoms in PWUD according to HADS was 33% and 41.5%, respectively, with depression (p = 0.05) and isolation status (adjusted OR = 2.63, p < 0.05) being associated with an increase in alcohol/illicit substance use during the COVID-19 pandemic. PWUD who had increased their intention to seek professional support had significantly higher odds (adjusted OR = 4.42, p < 0.01) of reducing their alcohol/illicit substance use during the COVID-19 pandemic period. There were increased odds of maintaining alcohol/illicit substance usage among PWUD who practiced dysfunctional coping (adjusted OR = 3.87, p < 0.025) during the COVID-19 pandemic period. In conclusion, depression, isolation status, dysfunctional coping, and intention to seek professional support affected the pattern of alcohol/illicit substance use during the COVID-19 pandemic period. Strategies, substance rehabilitation/counseling, and proper mental health screening and the associated risk factors must be emphasized to prevent a further epidemic of substance use during the pandemic.
Modeling Coding Intensity of Procedures in a U.S. Population-Based Hip/Knee Arthroplasty Inpatient Cohort Adjusting for Patient- and Facility-Level Characteristics
Authors: Rios Nancy G. , Oldiges Paige E. , Lizano Marcela S. , Doucet Wadford Danielle S. , Quick David L. , Martin John , Korvink Michael , Gunn Laura H.
Published: July 2022

Variations in procedure coding intensity, defined as excess coding of procedures versus industry (instead of clinical) standards, can result in differentials in quality of care for patients and have additional implications for facilities and payors. The literature regarding coding intensity of procedures is limited, with a need for risk-adjusted methods that help identify over- and under-coding using commonly available data, such as administrative claims. Risk-adjusted metrics are needed for quality control and enhancement. We propose a two-step approach to risk adjustment, using a zero-inflated Poisson model, applied to a hip-knee arthroplasty cohort discharged during 2019 (n = 313,477) for patient-level risk adjustment, and a potential additional layer for adjustment based on facility-level characteristics, when desired. A 21.41% reduction in root-mean-square error was achieved upon risk adjustment for patient-level factors alone. Furthermore, we identified facilities that over- and under-code versus industry coding expectations, adjusting for both patient-level and facility-level factors. Excess coding intensity was found to vary across multiple levels: (1) geographically across U.S. Census regional divisions; (2) temporally with marked seasonal components; (3) by facility, with some facilities largely departing from industry standards, even after adjusting for both patient- and facility-level characteristics. Our proposed method is simple to implement, generalizable, it can be used across cohorts with different sets of information available, and it is not limited by the accessibility and sparsity of electronic health records. By identifying potential over- and under-coding of procedures, quality control personnel can explore and assess internal needs for enhancements in their health delivery services and monitor subsequent quality improvements.
Gallstone Is Associated with Metabolic Factors and Exercise in Korea
Authors: Wang Hoyoung , So Hoonsub , Ko Sung Woo , Jung Seok Won , Bang Sung-Jo , Park Eun Ji
Published: July 2022

Gallstone is a common health problem. Cholesterol stone accounts for 90% of stones in the United States and Europe, but East Asia has a high proportion of pigment stone. The aim of this study was to determine the relationship between modifiable metabolic factors and gallstone in a region with a high prevalence of pigment stone. Among 3159 participants who underwent health screening at Ulsan University Hospital from March 2014 to June 2019, 178 patients were diagnosed with gallstone using abdominal ultrasonography; 2860 participants were selected as a control group. Demographic and laboratory data, and a medical questionnaire were obtained. Hypertension and diabetes mellitus were more prevalent in the gallstone group. Age, waist circumference, systolic blood pressure (SBP) ≥ 140 mmHg, fasting blood glucose, HbA1c ≥ 6.5%, visceral fat index, normal-attenuated muscle area index, and engaging in vigorous exercise for ≥2 days per week were associated with gallstone by univariate analysis. Through multivariate logistic regression analysis, HbA1c ≥ 6.5% (odds ratio (OR) 1.98, 95% confidence interval (CI) 1.31–2.98), and 2 or more days of vigorous exercise per week (OR 0.66, 95% CI 0.45–0.95) remained significant. The association persisted after adjusted analysis for age and sex. HbA1c ≥ 6.5% were positively associated with the gallstone. Vigorous exercise for at least 2 days weekly may be related to a lower risk of gallstone formation.