bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuropathic Extremity Pain in Patients With Multiple Sclerosis: Preventive and Personalized Approach
Authors: Uzunköprü Cihat , Yılmaz Gizem Öztürk , Beckmann Yeşim
Published: June 2021

BackgroundNeuropathic extremity pain is a disabling symptom in patients with multiple sclerosis. The aim of this study is to evaluate the prevalence of neuropathic extremity pain among patients with multiple sclerosis and to assess its effect on quality of life.MethodsThe present cross-sectional study included 180 patients with relapsing-remitting multiple sclerosis. Douleur Neuropathique 4 pain scale and Leeds Assessment of Neuropathic Symptoms and Signs pain scale were used to evaluate neuropathic pain. The effect of neuropathic extremity pain on quality of life was assessed by the 36-Item Short Form Survey. ResultsThe mean age and the mean disease duration were 38.78±9.37 and 8.96±6.93 years, respectively. The prevalence of neuropathic extremity pain was 38.9% in the Leeds Assessment of Neuropathic Symptoms and Signs pain scale and 47.8% in the Douleur Neuropathique 4 pain scale. The presence of neuropathic extremity pain was associated with the higher Expanded Disability Status Scale in the Leeds Assessment of Neuropathic Symptoms and Signs pain scale (p=0.015) and the longer disease duration in the Douleur Neuropathique 4 pain scale (p=0.021). All patients with psychiatric disorders reported neuropathic extremity pain. Lower 36-Item Short Form Survey scores were obtained in patients with neuropathic extremity pain than patients without neuropathic extremity pain in all domains of 36-Item Short Form Survey.ConclusionsThis study suggests that neuropathic extremity pain is a common symptom among patients with multiple sclerosis. Higher disability and longer disease duration are associated with neuropathic extremity pain. The presence of pain and psychiatric disorders are related to the impairment of the quality of life.Relevance of the article for predictive, preventive, and personalized medicine Questioning of pain is often neglected in multiple sclerosis practice. However, identification and treatment of pain has the potential to increase the quality of life in patients with multiple sclerosis. This article emphasizes that revealing the presence of pain might improve clinical outcome in multiple sclerosis patients providing personalized approaches to disease course.
Spinoza, Hegel, Deleuze y el problema de la inmanencia
Authors: Cuevas Luis H.
Published: June 2021

Inscribiéndose en el problema de la inmanencia, el artículo se centra en exponer los móviles por los cuales Deleuze afirma que Hegel traiciona el movimiento del pensar inmanente. Esto al descubrir en el pensamiento hegeliano un limitado spinozismo que, al esbozar una falsa dramatización del devenir, termina por asentar bulbos de trascendencia. Lo anterior se realiza apoyándonos en la manera en la que el hegelianismo fue recibo en Francia en el siglo XX. Recepción que desde la lectura de Judith Butler está afianzada en el problema del deseo, el cual halla como una de sus primeras expresiones los cursos que Alexandre Kojève dictó en la École Pratique des Hautes Études.
Ressignificação do TEPT a partir da clínica psicodinâmica do trabalho
Authors: Gomes Souza Ronaldo , Mendes Ana Magnólia
Published: June 2021

As exigências da gestão neoliberal globalizante atual precarizam as relações de trabalho, diminuem os direitos trabalhistas, negam a cidadania e são fontes de sofrimentos e doenças no trabalho como depressão, burnout, estresse, sobretudo o Transtorno de estresse pós-traumático (TEPT). O objetivo desse ensaio teórico é apresentar a perspectiva da clínica psicodinâmica do trabalho como possível solução dos trabalhadores ressignificarem o sofrimento patogênico do TEPT. O método da clínica psicodinâmica do trabalho consiste no processo de fala e escuta do sofrimento no trabalho. Para tal, é preciso conhecer o contexto e a organização do trabalho no qual os sujeitos adoecidos estão e criar condições na relação do pesquisador-clínico com os trabalhadores adoecidos para ressignifcarem o sofrimento causado pelo TEPT no trabalho, em diferentes etapas. Conclui-se que, uma vez que se reconhece o potencial sofrimento do TEPT no contexto laboral, a Psicologia do Trabalho precisa desenvolver novas alternativas éticas e políticas de intervenção que crie condições para os trabalhadores adoecidos vivenciarem situações de prazer e saúde no trabalho, tal é a proposta da clínica psicodinâmica do trabalho. Novos resultados estão em processo de desenvolvimento no Clinical Psychodynamic of Work Lab. at  University of Brasília para fortalecimento dessa perspectiva.
Complicatio-explicatio: Nicolás de Cusa y el camino hacia un Spinoza deleuziano
Authors: Heffesse Solange
Published: June 2021

La idea de expresión, central según Deleuze en la Ética de Spinoza, encuentra en el par de nociones complicatio-explicatio uno de sus antecedentes principales. Se trata de nociones que pertenecen a una larga tradición neoplatónica, y que indagan las relaciones de lo Uno y lo múltiple. En la reformulación renacentista del problema, ellas dan lugar a una radicalización de la concepción inmanentista de lo real, que subvierte los esquemas emanativos tradicionales. Nicolás de Cusa es una de las figuras centrales en esa transformación. En este trabajo, estudiaremos el desarrollo de la complicación-explicación en la ontología cusana del lo creado, el Universo o máximo contracto, que se expone en el Libro II de De docta ignorantia. Examinaremos también su recepción crítica por parte de Deleuze, en la interpretación que ofrece del spinozismo, pero también para la elaboración su propia ontología. Nuestro objetivo es doble: analizar la versión cusana de la teoría de la complicación-explicación y sus prolongaciones en la Ética, buscando destacar aquellos aspectos que convienen con el pensamiento deleuziano. Leemos, entonces, al Cusano como fuente de la obra de Deleuze, para mostrar cómo la complicatio-explicatio tiende a acercarnos al plano de inmanencia spinozista, y a un pensamiento de la Diferencia.
Rostro deshecho. Por un arte menor y sus alcances políticos en Deleuze
Authors: Castro-Serrano Borja , Fernández Ramírez Cristian
Published: June 2021

El presente texto tiene por objetivo evidenciar una de las posibles vinculaciones que existen entre arte y política en el pensamiento de Gilles Deleuze. Para lo anterior, se trabajará en base a la formulación del “proyecto baconiano” que Deleuze enuncia en su texto Lógica de la sensación y que tiene por principio deshacer el rostro. Dicho esto, desarrollamos el concepto de rostridad o rostrificación que el autor teoriza de modo crítico en contraposición al rostro deshecho, mostrando las vinculaciones entre el arte y la política. Se concluye con la idea de que un arte menor y una política menor afectaría y atravesaría este proyecto (político) baconiano que el autor llama “deshacer el rostro”.
Migraciones femeninas: Mujeres latinoamericanas indocumentadas rumbo a EEUU
Authors: Cárdenas-Rodríguez Rocío , Terrón-Caro Teresa , Vázquez Delgado Blanca
Published: June 2021

En este trabajo se analiza la migración femenina de México y Centroamérica rumbo a EEUU: las características principales del fenómeno, las rutas empleadas por las mujeres en su proceso migratorio y, derivado de la situación de vulnerabilidad en el que se encuentran –en general– los migrantes en tránsito por México, los potenciales peligros a los que se enfrentan en su trayecto de viaje. Para ello, presentamos los resultados de una investigación exploratoria desarrollada en la frontera de México a EEUU, lugar de paso para muchas de ellas. Empleando un cuestionario semiestructurado, obtuvimos información valiosa sobre la experiencia migratoria de mujeres migrantes indocumentadas, que nos permite caracterizarlas y aproximarnos a conocer sus extrategias de viaje y riesgos a los que se enfrentan.
El legado de Maritza Montero a la psicología comunitaria
Authors: González Irineo
Published: June 2021

Apreciada Maritza Montero Usted ha dejado huella imborrable en la psicología. Reciba mi respetuoso y cordial saludo, soy estudiante de tercero de psicología en la Universidad de Guadalajara, México. Me gustaría comentarle que encomio sus 10 distinciones, premios y reconocimientos, resalto con gusto el Premio de la Sociedad Interamericana de Psicología en 1995. Admiro sus 40 investigaciones, de los cuales me gustaría examinar “Análisis crítico de procesos y teoría del fortalecimiento comunitario”, 2004. Además me fue interesante darme cuenta de su extendida labor docente nacional e internacional.
En honor a la vida y obra de la autora Maritza Montero
Authors: Duval Hernández Natali Lisbeth
Published: June 2021

Apreciada Maritza Montero eres para mi un modelo intelectual. Tus aportes al proyecto de una psicología política son notables: el remarcado interés por temas como la participación, la identidad nacional y metodología sólo son algunos de tus grandes contribuciones a la psicología en general.
Una visión integral de la comunidad para la práctica psicosocial
Authors: Laverde Bedoya Daniela
Published: June 2021

Apreciada profesora Maritza Montero, la psicología comunitaria cobró vida gracias a ti. En tu mente se gestaron las ideas fundamentales para imprimir un giro conceptual y metodológico de psicología social logrando su orientación hacia una psicología más comprometida con los problemas sociales de los territorios latinoamericanos. La psicología comunitaria surge a partir de la crítica de la psicología social existente dado que no respondía a los problemas sociales presentes en el continente. Esto conllevo al análisis e investigación en la búsqueda de una psicología que fuera socialmente sensible.
La Teología de la Liberación y la Pedagogía del Oprimido, un camino hacia la emancipación
Authors: Pérez Vargas John Jairo , González Arcila Yuliana Andrea , Rodríguez Robayo Angélica Natali
Published: June 2021

El presente documento, tiene como finalidad presentar una breve descripción de las categorías Teología de la Liberación y Pedagogía del Oprimido, ambas entendidas como corrientes surgidas en los contextos de América Latina, donde la primera se caracteriza por surgir de la teología a partir de una nueva lectura del evangelio y aproximación crítica del pensamiento marxista interpretados de manera contextual, por su parte, la Pedagogía del Oprimido es abordada desde Freire, donde por medio de la acción educativa entendida de manera crítica busca que el oprimido se reconozca como tal siendo ello una oportunidad para encontrar caminos de emancipación de las estructuras opresoras.De esta manera, comprendiendo las generalidades de la Teología de la Liberación y de la Pedagogía del Oprimido, se pueden identificar algunos puntos de encuentro que permiten articular la reflexión en torno a la liberación, para ello es fundamental el desarrollo alrededor de las categorías de pobre y oprimido debido a que emergen como el centro de reflexión de ambos movimientos posibilitando el actuar político como medio por el cual se alcanza dicha liberación.
The Metaphysical origins of language. Phenomenological Reflections about language in M. Heidegger
Authors: Barragán Abreu Oscar
Published: June 2021

In his most famous work, Sein und Zeit, M.Heidegger does a brief analysis of language in the frame of the being-in as such. In it, he relates this phenomenon with the opening of Dasein, understanding, affective disposition, listening and silence. Nevertheless, we consider that to reach a broader understanding of language from Heidegger's approach; we cannot limit ourselves to a Sein und Zeit, rather we must analyze his principal lessons and conferences about the topic and relate also to the complete ontological structure of Dasein when asking the question about being. Therefore, we propose that language understands, means and expresses the being from the complete ontological structure of Dasein and when it becomes everydayness, it drags language, which inevitably becomes gossip (Gerede). We use the phenomenological method, also applying for hermeneutics a synthesis of its main lessons regarding the topic approximately between 1920 and 1940. The conclusion is that, paradoxically, language understood as listening (Hören), poetically determines the return, the resolution (Entschlossenheit) and the opening (Entschlossenheit) of Dasein to the question of being in its fullness.
El acceso abierto y sus paradojas
Authors: Millán Juan David , Cudina Jean Nikola , Ossa Julio César
Published: June 2021

El acceso abierto es una forma de promoción del acceso a la literatura académica libre de costos y sin restricción en la licencia (Björk et. al, 2010). El internet y la emergencia del World Wide Web fueron los elementos que hicieron posible el crecimiento de ésta forma de publicación. El modelo de acceso abierto surgió en la década del 90 como una forma alternativa de las revistas de suscripción.
Pedro Laín Entralgo: apropiación personal de la enfermedad. Aportes para una antropología cristiana
Authors: García Echeverri Jonny Alexander , Vallejo Cardona Jesús David , Duque Naranjo Nicolás , Jiménez Restrepo Alejandro
Published: June 2021

La presente investigación tiene como objetivo fundamental dilucidar el concepto de enfermedad a la luz del monismo dinamicista del médico español Pedro Laín Entralgo. Para hacerlo, se acoge el método antropológico integral requerido en la obra lainiana, a fin de explicar al ser humano desde tres vías de conocimiento: descripción (ciencias positivas), explicación (filosofía) y comprensión (poesía, religión). A partir de este método, Laín presentará al hombre como una realidad psicoorgánica dinámica (monismo dinamicista) que se estructura en una realidad personal (monismo personal), logrando así unificar al ser humano entre la biología y la biografía, posibilitando con ello a la persona ser el agente, actor y autor de su vida, y vivir cada circunstancia vital de su historia a partir de la apropiación y entrega. En suma, la visión antropológica integral formulada por Laín se convierte en una invitación especial para que toda persona reinterprete su experiencia patológica, no como un elemento que anula su vida, sino como un modo fundamental del ser del hombre que lo puede catapultar a un estado de creación de un nuevo sentido, en el que la enfermedad se convierte en un recurso para significar su existencia. Una consideración final: en su obra, Laín invita a los teólogos a dar una interpretación cristiana de la enfermedad que ayude a expresar su sentido, no como un padecimiento (pathos), sino como un llamado a dar un testimonio (ser martyr) esperanzador a toda persona que sufre una situación similar.
Educar en la finitud. Contribuciones para pensar el fundamento de la educación con Heidegger y Sartre
Authors: Yepes Muñoz Wilfer Alexis
Published: June 2021

Este artículo pretende reflexionar acerca del fundamento de la educación a partir de un movimiento del pensar que se orienta en la finitud. Para ello, toma categorías como el Dasein heideggeriano, principalmente el existenciario ser-para-la-muerte, y el para-sí sartreano, que, con todos sus matices, sacan el ser de su propio olvido y posibilitan una reflexión pedagógica que acoge la finitud como alternativa para mantener el estado de apertura de la existencia. Mediante un ejercicio hermenéutico, se vincularon algunos conceptos de la filosofía existencial a un diagnóstico de la educación en el horizonte del olvido del ser, vislumbrando a su vez un ejercicio de fundamentación que amplía el horizonte para pensarla y transformarla.
Generalized normal forms of the systems of ordinary differential equations with a quasi-homogeneous polynomial (ax1^2 + x2, x1x2) in the unperturbed part
Authors:   St. Petersburg State University, Basov Vladimir V. , Zefirov Artem V. ,   St. Petersburg State University
Published: June 2021

In this paper a study on constructive construction of the generalized normal forms (GNF) is continued. The planar real-analytical at the origin system is considered. Its unperturbed part forms a first degree quasi-homogeneous first degree polynomial (αx21 + x2, x1x2) of type (1, 2) where parameter α ∈ 2 (-1/2, 0)[(0, 1/2]. For given value of this polynomial is a canonical form, that is an element of a class of equivalence relative to quasi-homogeneous substitutions of zero order into which any first order quasi-homogeneous polynomial of type (1, 2) is divided in accordance with the chosen structural principles due to it only making sense to reduce the systems with the various canonical forms in their unperturbed part to GNF. Based on the constructive method of resonance equations and sets, the resonance equations are derived. Perturbations of the acquired system satisfies these equations if an almost identity quasi-homogeneous substitution in the given system is applied. Their validity guarantees formal equivalence of the systems. Besides, resonance sets of coefficients are specified that allows to get all possible GNF structures and prove reducibility of the given system to a GNF with any of specified structures. In addition, some examples of characteristic GNFs are provided including that with the parameter leading to appearance of an additional resonance equation and the second nonzero coefficient of the appropriate orders in GNFs.
Power series of several variables with condition of logarithmical convexity
Authors:   St. Petersburg Electrotechnical University LETI, Zheleznyak Alexandr V.
Published: June 2021

We obtain a new version of Hardy theorem about power series of several variables reciprocal to the power series with positive coefficients. We prove that if the sequence {as} = as1,s2,...,sn, ||s|| ≥ K satisfies condition of logarithmically convexity and the first coefficient a0 is sufficiently large then reciprocal power series has only negative coefficients {bs} = bs1,s2,...,sn, except b0,0,...,0 for any K. The classical Hardy theorem corresponds to the case K = 0, n = 1. Such results are useful in Nevanlinna - Pick theory. For example, if function k(x, y) can be represented as power series Σn≥0 an(x-y)n, an > 0, and reciprocal function 1/k(x,y) can be represented as power series Σn≥0 bn(x-y)n such that bn < 0, n > 0, then k(x, y) is a reproducing kernel function for some Hilbert space of analytic functions in the unit disc D with Nevanlinna-Pick property. The reproducing kernel 1/1-x-y of the classical Hardy space H2(D) is a prime example for our theorems.
Linear Kalman-Bucy filter with vector autoregressive signal and noise
Authors:   St. Petersburg State University, Tovstik Tatiana M.
Published: June 2021

The linear Kalman-Bucy filter problem for a system, at that a signal and a noise are vector independent stationary autoregressive processes with orders larger than 1, is investigated. The recurrent equations for filter and its error are delivered. The optimal way of the initial data definition is proposed. Some numerical examples are given. In one of them the algorithm leads to a stationary behavior at infinity. In the other example the Kalman- Bucy filter is impossible because the filter error goes to infinity. A behavior of a signal and its error is illustrated by a simulation of a signal and a noise as vector Gaussian stationary autoregressive processes. The simulation supports theoretical conclusions.
Influence of unit cell parameters of tetrachiral mechanical metamaterial on its effective properties
Authors:   National Research Tomsk State University, Akhmetshin Linar R. ,   Institute of Strength Physics and Materials Science SB RAS, Smolin Igor Yu. ,   National Research Tomsk State University,   Institute of Strength Physics and Materials Science SB RAS
Published: June 2021

In the paper, we study the mechanical behavior of a three-dimensional chiral mechanical metamaterial using numerical modeling. A feature of chiral structures is that during their uniaxial loading a twisting is observed along the loading axis. A rod of the mechanical metamaterial composed of 3 × 3 × 9 unit cells along the corresponding three orthogonal axes. The relative strain of uniaxial compression of the sample in the simulation did not exceed 3.3%. The simulation was performed by the finite element method in a threedimensional case. Original results on the dependencies of the rotation angle and the reaction of the rigidly fixed support of the metamaterial sample on the parameters characterizing the structure of the unit cell of the metamaterial are presented in this context. All the dependencies, except one, are nonlinear with portions of large and small changes.
Determination of rotational derivatives of a cylinder with a coaxially mounted disk in an air stream
Authors:   St. Petersburg State University, Ryabinin Anatoly N. , Kaufman Daniil V. ,   St. Petersburg State University
Published: June 2021

The damped rotational oscillations of a cylinder whose length-to-diameter ratio is nine are considered. In the head part of the cylinder, a disc is mounted coaxially on the leg. The effect of the disk on damping oscillations is described by two parameters: the sum of the rotational derivatives mωz + mθz and the rotational derivative mθz. To determine these parameters in the aerodynamic tunnel of low speeds, an experiment is performed with the flow past a cylinder fixed on an elastic spring suspension. In the experiment, the diameter of the coaxial disk and the distance between the disk and the end of the cylinder varies. Deflected from the equilibrium position, the cylinder performs damping oscillations. The tension of one of the springs of suspension is measured using the strain gauge method. The signal is converted to digital form using the Velleman PCS500A PC oscilloscope and recorded to a file on the computer. Thus, the frequency of oscillations and the dependence of the amplitude of oscillations on time are determined. Disks whose diameter exceeds the diameter of the cylinder do not have a strong effect on the damping of oscillations of an elastically fixed cylinder. Disks of smaller diameter promote rapid damping of the oscillations. The presence of a large-diameter disk leads to a decrease in the coefficient mωz. A small-diameter disk acts in a opposite way.
Flood forecasting using an improved NARX network based on wavelet analysis coupled with uncertainty analysis by Monte Carlo simulations: a case study of Taihu Basin, China
Authors: Jiang Feiqing , Dong Zengchuan , Wang Zeng'an , Zhu Yiqing , Liu Moyang , Luo Yun , Zhang Tianyan
Published: June 2021

Reliable flood forecasting can provide a scientific basis for flood risk assessment and water resources management, and the Taihu water level forecasting with high precision is essential for flood control in the Taihu Basin. To increase the prediction accuracy, a coupling model (DWT-iNARX) is established by combining the discrete wavelet transformation (DWT) with improved nonlinear autoregressive with exogenous inputs network (iNARX), for predicting the daily Taihu water level during the flood season under different forecast periods. And the DWT-iNARX model is compared with the back-propagation neural network (BP) and iNARX models to assess its capability in prediction. Meanwhile, we propose an uncertainty analysis method based on Monte Carlo simulations (MCS) for quantifying model uncertainty and performing probabilistic water level forecast. The results show that three models achieve good simulation results with higher accuracy when the forecast period is short, such as 1–3 days. In overall performance, iNARX and DWT-iNARX models show superiority in comparison with the BP model, while the DWT-iNARX model yields the best performance among all the other models. The research results can provide a certain reference for the water level forecast of the Taihu Lake.
A Case of Pulmonary Tuberculosis Mimicking as Diffuse Alveolar Hemorrhage: A Case Report
Authors: Chand Trilok , Thomas Georgie , Khan M. U.
Published: June 2021

Background:

Pulmonary tuberculosis (TB) and diffuse alveolar hemorrhage (DAH) have some commonalities in several parts of the world. However, acute
hemoptysis with diffuse alveolar shadows while a patient is on anticoagulant and antiplatelet therapy for a specific reason suggests DAH over TB.

Case Presentation:

In this case, a patient was presented with acute respiratory symptoms with hypoxia and bilateral alveolar shadows. He was treated for DAH at the
initial encounter. However, on follow-up, he was confirmed having active pulmonary TB based on sputum acid-fast-bacilli culture.

Conclusion:

He was successfully treated with standard first-line anti-tubercular therapy and was subsequently declared cured. Pulmonary DAH with TB, in the
absence of an underlying autoimmune disorder, is rare.
Synthetic Approaches Toward Diversely Substituted 1,2,2-triarylethanones
Authors: Abonia Rodrigo , Montoya Oscar
Published: June 2021

Carbon-carbon bond formation is the essence of organic synthesis, and for that,
many strategies have been developed to accomplish this goal. Several of these strategies are
conducted to form diverse structures bearing the α,α-diarylcarbonyl motif, in the form of
1,2,2-triarylethanones, which are unities present in a number of natural products and biologically
active compounds. These privileged carbonyl compounds have been used as building
blocks or intermediates for the synthesis of dibenzo[a,c]phenanthridines, analogues of biologically
active benzo[c]phenanthridine alkaloids, as well as useful synthons for Droloxifene and
remarkably for Tamoxifen, the most widely used drug for the treatment of breast cancer.

Focusing on the literature progress from 2000 to 2020 and considering the synthetic and biological
value of the aforementioned carbonyl compounds, the present review explores the
diverse metal-free, metal-mediated, C–H bond activation, α-monoarylation, α,α-diarylation, umpolung processes, Nheterocyclic
carbene (NHC), and deoxygenation, among other synthetic approaches directed to the synthesis of
1,2,2-triarylethanone derivatives. Moreover, several of their mechanistic proposals are also briefly discussed in this
review. In view that most of these strategies are accompanied by carbon-carbon bonds formation through ketonebased
α-arylation processes, the reported data are organized into concise Tables/Schemes to facilitate comparison,
and to underscore the key points of this review.
Application of In silico Methods in the Design of Drugs for Neurodegenerative Diseases
Authors: Haider Mohamad , Chauhan Anjali , Tariq Sana , Pathak Dharam Pal , Siddiqui Nadeem , Ali Soni , Pottoo Faheem Hyder , Ali Ruhi
Published: June 2021

Neurodegenerative diseases are complex disorders that cause neuron loss, brain aging
and ultimately lead to death. These diseases are difficult to treat because of the complex nature of
the nervous system, and the available medicines are unable to heal them effectively. This fact implies
the need for novel therapeutics to be designed that are ready to stop or a minimum of retard
the neurodegeneration process. These days, Computer-Assisted Drug Design (CADD) approaches
are a passage to extend the drug development efficiency and to reduce time and cost because traditional
drug discovery is both time-consuming as well as costly. Computational or in silico methods
came up with powerful tools in drug design against neurodegenerative diseases. This review presents
the approaches and theoretical basis of CADD. Also, the successful applications of various in
silico studies, including homology modeling, molecular docking, Quantitative Structure-Activity
Relationship (QSAR), Molecular Dynamic (MD), De novo drug design, Pharmacophore-based
drug design, Virtual Screening (VS), LIGPLOT Analysis, In silico ADMET and drug safety prediction,
for treating neurodegenerative diseases have also been included in this review. Major emphasis
is given to Alzheimer’s disease and Parkinson’s disease because these two are the most familiar
neurodegenerative diseases.
Development of a Gene Expression Panel, for the Prediction of Protein Abundances in Cancer Cell Lines
Authors: Lee Gunhee , Chung Yeun-Jun , Lee Minho
Published: June 2021

Background:

Due to the ease of quantifying mRNA expression in comparison with that of
protein abundances, many studies have utilized it to infer protein product quantification. However, the
mRNA expression values for a gene and its protein products are not known to have a strong relationship,
because of the complex mechanisms required to regulate the amounts of protein levels, from
translation to post-translational modifications.

Methods:

We have developed, in this study, models to predict protein levels from mRNA expression
levels using the transcriptome and reverse phase protein arrays (RPPA)-based on protein levels in pancancer
cell lines. When predicting the abundance of a protein expression, in addition to using RNA
expression of the corresponding gene, we also used RNA expression levels of a particular set of other
genes. By applying support vector regression, we have identified a 47-gene expression panel that contributes
to the improved performance of the prediction, and its optimal subsets specific to each protein
species.

Result and Conclusion:

Eventually, our final prediction models doubled the number of predictable
protein expressions (r > 0.7). Due to the weaknesses of RPPA, our model had some limitations, however,
we expect that these prediction models and the panel can be widely used in the future to infer
protein abundances.
PREDAIP: Computational Prediction and Analysis for Anti-inflammatory Peptide via a Hybrid Feature Selection Technique
Authors: Lin Dan , Yu Jialin , Zhang Ju , He Huan , Guo Xinyun , Shi Shaoping
Published: June 2021

Background:

Anti-Inflammatory Peptides (AIPs) are potent therapeutic agents for inflammatory
and autoimmune disorders due to their high specificity and minimal toxicity under
normal conditions. Therefore, it is greatly significant and beneficial to identify AIPs for further
discovering novel and efficient AIPs-based therapeutics. Recently, three computational approaches,
which can effectively identify potential AIPs, have been developed based on machine learning
algorithms. However, there are several challenges with the existing three predictors.

Objective:

A novel machine learning algorithm needs to be proposed to improve the AIPs prediction
accuracy.

Methods:

This study attempts to improve the recognition of AIPs by employing multiple primary
sequence-based feature descriptors and an efficient feature selection strategy. By sorting features
through four enhanced minimal redundancy maximal relevance (emRMR) methods, and then attaching
seven different classifiers wrapper methods based on the sequential forward selection algorithm
(SFS), we proposed a hybrid feature selection technique emRMR-SFS to optimize feature
vectors. Furthermore, by evaluating seven classifiers trained with the optimal feature subset, we
developed the Extremely Randomized Tree (ERT) based predictor named PREDAIP for identifying
AIPs.

Results:

We systematically compared the performance of PREDAIP with the existing tools on independent
test dataset. It demonstrates the effectiveness and power of the PREDAIP.

Conclusion:

The correlation criteria used in emRMR would affect the selection results of the optimal
feature subset at the SFS-wrapper stage, which justifies the necessity for considering different
correlation criteria in emRMR.
Informative Gene Selection Based on Cost-Sensitive Fast Correlation- Based Filter Feature Selection
Authors: Xiong Yueling , Li Qingqing , Wang Peipei , Ye Mingquan
Published: June 2021

Background:

Informative gene selection is an essential step in performing tumor classification.
However, it is difficult to select informative genes related to tumors from large-scale gene
expression profiles because of their characteristics, such as high dimensionality, relatively small
samples, and class imbalance, and some genes are superfluous and irrelevant.

Objective:

Many researchers analyze and process gene expression data to obtain classified gene
subsets by using machine learning methods. However, the gene expression profiles of tumors often
have massive computational challenges. In addition, when improving feature importance and classification
accuracy, cost estimation is often ignored in traditional feature selection algorithms,
which makes tumor classification more difficult.

Methods:

In this study, a novel informative gene selection method based on cost-sensitive fast correlation-
based filter (CS-FCBF) feature selection is proposed.

Results:

First, the symmetric uncertainty index is used to evaluate the correlation between informativeFirst, the symmetric uncertainty index is used to evaluate the correlation between informative
genes and class labels, then a large number of irrelevant and redundant genes are quickly
filtered according to importance. Thereby, a candidate gene subset is generated. Second, costsensitive
learning, which introduces the misclassification cost matrix and support vector machine
attribute evaluation, is used to obtain the top-ranked gene subset with minimum misclassification
loss. Finally, the candidate gene subset is optimized.
genes and class labels, then a large number of irrelevant and redundant genes are quickly
filtered according to importance. Thereby, a candidate gene subset is generated. Second, costsensitive
learning, which introduces the misclassification cost matrix and support vector machine
attribute evaluation, is used to obtain the top-ranked gene subset with minimum misclassification
loss. Finally, the candidate gene subset is optimized.

Conclusion:

This experiment was verified in eight independent tumor datasets. By comparing and
analyzing CS-FCBF with another three hybrids of typical gene selection algorithms combined with
cost-sensitive learning, we found that the method proposed in this study has a better classification
performance with fewer selected genes, which might provide guidance in tumor diagnosis and research.
Revisiting the Antiviral Efficacy of Terpenoids: Plausible Adjunct Therapeutics
for Novel SARS-CoV-2?
Authors: Ahmad Afza , Tiwari Rohit Kumar , Ansari Irfan Ahmad
Published: June 2021

:

Presently the world is witnessing the most devastating pandemic in the history of
mankind caused by Severe Acute Respiratory Syndrome or SARS-CoV-2. This dreaded pandemic
is responsible for escalated mortality rates across the globe and this is the worst catastrophe in the
history of mankind. Since its outbreak, substantial scientific explorations focusing on the formulation
of novel therapeutical and/or adjunct intervention against the disease are continuously in the
pipeline. However, till date, no effective therapy has been approved and hence the present alarming
situation urges the necessity of exploring novel, safe and efficient interventional strategies. Functionally,
terpenoids are a class of secondary plant metabolites having multi facet chemical structures
and are categorically documented to be the largest reservoir of bioactive constituents, predominant
in nature. Intriguingly, very little is scientifically explored or reviewed in regards to the anti-CoV-2
attributes of terpenoids. The present article thus aims to revisit the antiviral efficacy of terpenoids
by reviewing the current scientific literature and thereby provide an opinion on the plausibility of
exploring them as potential therapeutical intervention to deal with ongoing CoV-2 pandemic.
Research on Electrochemical Machining of Small Deep Holes with Positive
and Negative Pulse Power
Authors: Li Zhaolong , Cao Bingren
Published: June 2021

Background:

High-temperature alloys, such as the nickel-based alloy, have become the
main materials for core components in the aerospace field because of their high strength and good
toughness. Therefore, how to improve the machining accuracy and stability of electrochemical machining
(ECM) of small deep holes on nickel-based alloy is an important topic for studies. The instantaneous
high-density current during the pulse width of pulse ECM is beneficial to the dissolution
of nickel-based alloy. Many experts and scholars have studied pulse ECM of small deep holes.

Objective:

The purpose of this article is to propose and design a positive and negative pulse (PANP)
power supply to study the accuracy and stability of ECM of small deep holes on the nickel-based
alloy.

Methods:

First of all, an H-bridge composed of four MOSFET switches is designed to achieve
PANP output in the main circuit of the power supply. Then, this article discusses the influence of
the ratio of positive and negative pulses on short circuits, the influence of the ratio of positive and
negative pulses on the mass removal rate, and the influence of the electrolyte concentration and
pulse width on the mass removal rate. Finally, according to the obtained optimal parameters, the influence
of the electrolyte pressure on the average radial overcut of hole depth is analyzed.

Results:

The experimental results show that the short-circuit frequency is reduced by more than
50% compared with non-negative pulses power supply; the ratio of positive and negative pulses,
pulse width, and electrolyte concentration and pressure were optimized by experiments in order to
improve the mass removal rate of the workpiece and the average radial overcut of hole depth.

Conclusion:

The designed PANP power supply can improve the machining accuracy and stability
of ECM of small deep holes on the nickel-based alloy.
2D and Layered Ti-based Materials for Supercapacitors and Rechargeable
Batteries: Synthesis, Properties, and Applications
Authors: Ni Wei , Shi Lingying
Published: June 2021

:

Titanium-based two-dimensional (2D) and layered compounds with open and stable crystal
structures have attracted increasing attention for energy storage and conversion purposes, e.g., rechargeable
alkali-ion batteries and hybrid capacitors, due to their superior rate capability derived from
the intercalation-type or pseudocapacitive kinetics. Various strategies, including structure design, conductivity
enhancement, surface modification, and electrode engineering, have been implemented to
effectively overcome the intrinsic drawbacks while simultaneously maintaining their advantages as
promising and competitive electrode materials for advanced energy storage and conversion. Here, we
provide a comprehensive overview of the recent progress on Ti-based compound materials for highrate
and low-cost electrochemical energy storage applications (mainly on rechargeable batteries and
supercapacitors). The energy storage mechanisms, structure-performance relations, and performanceoptimizing
strategies in these typical energy storage devices are discussed. Moreover, major challenges
and perspectives for future research and industrial application are also illustrated.
Pengaruh Kecepatan Pengadukan pada Proses Stircasting terhadap Sifat Mekanik pada Paduan Aluminium
Authors: Jauhari Mochamad Helmi , Darmadi Djarot B , Widodo Teguh Dwi
Published: June 2021

The composite material is a material composed of a mixture or combination of two or more of the major elements that macro differ in shape and material composition that basically can not be separated. In this research, the aluminum used was the outcome of production cesspool with the addition of volcanic dust from Mount Kelud by 2% as reinforcement. The stir casting process is the casting process by adding a material (powder form) in pure metal (aluminum), which has been melted and then stirring constantly. After that, the composite materials (the volcanic dust from Mount Kelud) were mixed slowly into the stirred liquid material. In this research, the variations of stirring speed were 0,200,300,400,500  and 600 rpm. The stirring each time for 4 minutes. In this study, the stirring speed in the casting process was 0, 200, 300, 400, 500, and 600 rpm. Tensile test, Impact test, and microstructure observations were carried out on the casting results. From these tests, the highest modulus of elasticity and impact value was obtained at the 600rpm stirring process. It may due to globular grains are more evenly distributed. And the result of metallographic testing was stirring speed could affect the amount and density of composite grain structure. The faster the stirring, the grain structure was getting smaller and close.
Uji Performa Mesin Bensin dengan Sistem Injeksi Berbahan Bakar HCNG
Authors: Sasongko Mega Nur , Zuhri Abdi Afifuddin
Published: June 2021

Compressed Natural Gas (CNG) is an alternative renewable fuel gasoline replacement. However, due to the low heating value, the use of CNG in the engine will reduce its performance. The addition of hydrogen gas in CNG namely hydrogen-enriched compressed natural gas is expected to increase the power of the motor. This study aims to analyze the effect of hydrogen concentration on the performance of a CNG gasoline engine. The research was conducted on the engine with an indirect fuel injection system with a volume of 124,9 cc. The parameter of the engine that measured is torque, effective power, specific fuel consumption, and effective thermal efficiency. The results showed that the small percentage of hydrogen in CNG could increase the power of the gasoline engine. Power and efficiency reach a maximum of 10% hydrogen concentration. Increasing the proportion of hydrogen in CNG fuel above 10% will significantly reduce engine torque and power. Engine performance at optimal conditions with 10% hydrogen results in torque of 2.71 Kg.m at 670 rpm, effective power of 3.28 Ps at 1055 rpm, SFCe 0.17 Kg / Ps. Hours at 770 rpm and 33.62% effective thermal efficiency at 770 rpm
Principles for determining effective parameters for organizing train traffic in suburban-urban traffic, taking into account the differentiation of service classes
Authors: Borodin A. F. , Mustafin I. F. , Nikolaev K. Yu.
Published: June 2021

Introduction of a new transport product in urban agglomerations helps to attract additional passenger traffic by changing parameters of organizing the operation of suburban trains. Problem of determining the effective parameters of the route network of suburban-urban railway communication in order to achieve acceptable financial results for the owners of infrastructure and carriers is considered. Controlled variables are determined that characterize the route network of suburban-urban traffic and include the type of train schedule, the operation interval, the routes, the traffic volume of suburban-urban trains, the station of departure and arrival, the service class. It was also determined that the distribution of passenger traffic correspondence over the network of transport products depends both on a set of controllable variables and on the time of travel by rail when using a transport product, taking into account the execution of terminal operations at points of departure, destination, transfers, waiting for trains, and travel on trains. The objective function for the carrier and the owner of the infrastructure, which is identical for both participants of transportation, is considered, while the components of investment costs and direct production costs for transportation activities and income receipts that ensure the break-even of this activity are different for each participant in transport services. Relevant constraints for the task, due to the resources of the railway infrastructure and rolling stock, have been determined. Authors provides the principles of solving this multicriteria problem by finding a group of the best options by a directed enumeration of alternatives with the subsequent selection of the resulting solution by the methods of compromise control. The research results are intended for use in projects for the development of suburban-urban traffic in large urban agglomerations.
Development and evaluation of a complex of studies to increase the frequency of bending vibrations of modern passenger car bodies
Authors: Skachkov A. N. , Samoshkin S. L. , Korshunov S. D. , Nikiforov D. A. , Romashov D. A.
Published: June 2021

Investigations of the frequency of bending vibrations of the car bodies of 61-4440 model range, which includes compartment cars, staff cars, non-compartment cars, coach cars, restaurant cars and others, are described. The bodies of all cars of this model range have the same overall dimensions and are made of corrosionresistant steels (stainless) with flat corrugated sheathing of the lower (under the window) belt.

To assess the influence of the design features of stainless steel bodies on its bending stiffness and the parameters of bending vibrations in the vertical plane, a computational and experimental complex of works was carried out.

After analyzing the calculation results and experimental data, proposals were developed and implemented to increase the bending stiffness of the metal body structure with stainless steel skin. To check the implemented proposals, complex tests were carried out to determine the parameters of bending vibrations of the metal structure of the experimental body. The tests were carried out according to the combined method developed by the authors. For this, a vibrator, installed in the console parts of the body, and impulse excitation were used.

The results of testing the metal structure of the experimental body in comparison with the results of testing the car bodies of 61-4440 model range showed the effectiveness of the implemented proposals, namely: increasing the frequency of the first tone of bending vibrations by 18 %; decrease in the amplitude of vertical vibrations of the body structure at the frequency of the first tone from 12 to 50 %; decrease in the amplitude of the vertical accelerations of the metal structure of the body during oscillations at the frequency of the first tone approximately by 2 times; significant reduction in horizontal acceleration in the area of the middle section walls. The effectiveness of the implemented proposals for increasing the bending stiffness of the metal structure of the experimental body allows recommending them for the entire model range of 61-4440 cars.
Mucinous Cystadenoma of the Ovary Associated with Hyperplasia of Stromal Leydig Cells in Pregnant Woman
Authors: Bartoš Vladimír
Published: June 2021

Background: The hormonally induced non-neoplastic lesions of ovarian stroma during pregnancy must be recognized by pathologist in order to avoid mistaking them for true tumors.

Case report: A 28-year-old woman was delivered of a healthy infant by cesarean section. As an incidental finding, a multicystic tumor in the left ovary was found and resected. Histopathology was consistent with benign mucinous cystadenoma. In addition, within the stroma beneath the lining mucinous epithelium, a dense population of cohesive polygonal cells with abundant eosinophilic cytoplasm, typically resembling the Leydig cells, was seen. They were uniform without atypia, accompaning by minimal proliferative activity. They strongly expressed vimentin, inhibin, CD99 and calretinin. The final diagnosis of mucinous cystadenoma associated with hyperplasia of stromal Leydig cells was made.

Conclusions: Leydig cell hyperplasia belongs to the specific changes of ovarian stroma associated with pregnancy. The present case stresses that in such situation the pathologists should be aware of it and not confuse it with a tumor.
Jurisdictional Challenges in the 21st Century Security Environment
Authors: McAuley William
Published: June 2021

What security and intelligence strategies do subnational governments require to protect themselves and the social, cultural, economic, and safety interests of their citizens? Although subnational governments wield important levers in areas now inhabited by an expanding array of domestic and foreign threat actors, few have any coherent security and intelligence culture, architecture, or strategy. This paper seeks to address the conspicuous absence of discourse on contemporary subnational security challenges, suggesting that subnational security strategies are an inescapable requirement of the 21st century security environment. Given that the inception of any form of polycentric security strategy with an enabling architecture and culture is a complex undertaking, the utility of the design-basis threat concept is explored to provide a tangible starting point for evaluation of key drivers for analysis in the contemporary subnational security environment. A simplified framework for a provincial-level design-basis threat analysis is proposed as a gateway to deeper analysis.