bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on etch characteristics of magnetic tunnel junction materials using rf-biased H2/NH3 reactive ion beam
Authors: Kim Ye Eun , Kim Doo San , Jang Yun Jong , Gil Hong Seong , Jeon Ho Seop , Hong Jong Woo , Kim In Ho , Kim Cheol , Park Jeong-Heon , Yeom Geun Young
Published: April 2023

In order to etch CoFeB and MgO constituting the magnetic tunnel junction (MTJ) layer of magnetic random access memory, rf-biased reactive ion beam etching (RIBE) with a H2:NH3 gas mixture was introduced and the etching characteristics were investigated. The H2:NH3 gas mixture of 8:1 was used for rf-biased RIBE because the etch selectivity is increased with H2 percentage in the H2:NH3 gas mixture while the etch rates of MTJ materials are the highest between 2:1 and 1:1 ratio of H2:NH3 due to the synergy effect of H2 and NH3 in the etching of MTJ materials. When a high rf power was applied to the substrate (high rf-biasing) during RIBE, even though etch rates of MTJ materials were increased, the etch selectivities of MTJ materials over hard mask materials were decreased possibly due to the high physical sputtering effect. However, when small rf-biasing was added to the substrate during RIBE, improved etch characteristics such as higher etch selectivity of MTJ over the top electrode (TE) material, improved etch anisotropy of the MTJ pattern masked with TE, and a thinner sidewall residue on the MTJ pattern could be observed. The improvement in etch characteristics by the addition of small rf-biasing during RIBE is believed to be related to the increased chemical etching effect through H2/NH3 gas dissociation and the increased H/NH ratio in the plasma generated just above the substrate without increasing the physical sputtering effect. Specifically, for the substrate located on the insulating substrate holder, the charging of the substrate could be removed without using an electron emitting neutralizer by supplying electrons from the plasma generated by rf-biasing during RIBE.
A multi-fidelity Gaussian process for efficient frequency sweeps in the acoustic design of a vehicle cabin
Authors: Gurbuz Caglar , Eser Martin , Schaffner Johannes , Marburg Steffen
Published: April 2023

Highly accurate predictions from large-scale numerical simulations are associated with increased computational resources and time expense. Consequently, the data generation process can only be performed for a small sample size, limiting a detailed investigation of the underlying system. The concept of multi-fidelity modeling allows the combination of data from different models of varying costs and complexities. This study introduces a multi-fidelity model for the acoustic design of a vehicle cabin. Therefore, two models with different fidelity levels are used to solve the Helmholtz equation at specified frequencies with the boundary element method. Gaussian processes (GPs) are trained on each fidelity level with the simulation results to predict the unknown system response. In this way, the multi-fidelity model enables an efficient approximation of the frequency sweep for acoustics in the frequency domain. Additionally, the proposed method inherently considers uncertainties due to the data generation process. To demonstrate the effectiveness of our framework, the multifrequency solution is validated with the high-fidelity (HF) solution at each frequency. The results show that the frequency sweep is efficiently approximated by using only a limited number of HF simulations. Thus, these findings indicate that multi-fidelity GPs can be adopted for fast and, simultaneously, accurate predictions.
De Novo
Whole-Genome Sequencing of Two Pathogenic Pasteurella multocida Type D:6 Strains Isolated from Pigs
Authors: Livingstone Morag , Jorgensen Pernille , McCall Margaret , Thomson Jill , Longbottom David
Published: April 2023

Here, we report the complete genome sequences of
Pasteurella multocida
strains P504190 and P504188/1, which were isolated from the diseased lungs of a sow and her piglet, respectively. Despite the unusual clinical presentation, whole-genome sequence typing revealed both strains to be capsular type D and lipopolysaccharide (LPS) group 6, commonly found in pigs.
Strict Conservation yet Non-Essential Nature of Plasmid Gene
bba40
in the Lyme Disease Spirochete Borrelia burgdorferi
Authors: Kasumba Irene N. , Tilly Kit , Lin Tao , Norris Steven J. , Rosa Patricia A.
Published: April 2023

The key finding of this study contradicts our premise that the ubiquitous presence and strict sequence conservation of a unique gene in the Lyme disease spirochete,
Borrelia burgdorferi
, reflect a critical role in either the murine host or tick vector in which these bacteria are maintained in nature. Instead, the outcome of this investigation illustrates the inadequate nature of the experimental infectious cycle currently employed in the laboratory to fully model the enzootic cycle of the Lyme disease spirochete.
Positron Emission Tomography-Computed Tomography and Magnetic Resonance Imaging Assessments in a Mouse Model of Implant-Related Bone and Joint Staphylococcus aureus Infection
Authors: Aguilera-Correa J. J. , Salinas B. , González-Arjona M. , de Pablo D. , Muñoz P. , Bouza E. , Fernández Aceñero M. J. , Esteban J. , Desco M. , Cussó L.
Published: April 2023

Our results encourage future investigations on the utility of the model for testing different therapeutic procedures for osteomyelitis.
Regional Evaluation of Two SARS-CoV-2 Antigen Rapid Diagnostic Tests in East Africa
Authors: Affara Muna , Lagu Hakim Idris , Achol Emmanuel , Omari Neema , Ochido Grace , Kezakarayagwa Eric , Kabatesi Francine , Nduwimana Cassien , Nkeshimana Anatole , Duku Samson Donald , Awin Nykwec Gwokpan , Daniel Wani Lako Joseph , Lasuba Michael , Lojok Deng Lul , Ezekiely Kelly Maria , Bernard Mtesigwa Mkama Peter , Magesa Alex , Said Ali Salum , Amour Rashid Sabra , Pimundu Godfrey , Muyigi Tonny , Ndidde Nabadda Susan , Rutayisire Robert , Kabanda Alice , Kabalisa Emmanuel , May Jürgen , Nzeyimana Eric , Katende Michael , Gehre Florian
Published: April 2023

Accurate diagnostic tests are essential to both support the management and containment of outbreaks, as well as inform appropriate patient care. In the case of the SARS-CoV-2 pandemic, antigen Rapid Diagnostic Tests (Ag-RDTs) played a major role in this function, enabling widespread testing by untrained individuals, both at home and within health facilities.
AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer
Authors: Shi Zhikun , Yuan Hao , Cao Lanqing , Lin Yang
Published: April 2023

Resistance to cisplatin (DDP)-based chemotherapy is an important reason for the failure of ovarian cancer treatment. However, tumor cells resistant to chemotherapy may expose vulnerability to other cell death pathways. Here, we found that DDP-resistant ovarian cancer cells are more susceptible to erastin-induced ferroptosis. It should be noted that this vulnerability does not depend on the weakening of classical ferroptosis defense proteins, but is caused by the reduction of ferritin heavy chain (FTH1). DDP-resistant ovarian cancer cells maintain a high level of autophagy to escape the pressure of chemotherapy, which ultimately leads to increased autophagic degradation of FTH1. We further revealed that the loss of AKT1 was the reason for the increased autophagy level of DDP-resistant ovarian cancer cells. Our study provides new insights into reversing DDP resistance in ovarian cancer by targeting ferroptosis pathway, and AKT1 may be a molecular marker of susceptibility to ferroptosis.
Improvement of tailings impoundment seismic and post-seismic stability using densification and waste rock inclusions
Authors: Contreras Carlos Andrés , Yniesta Samuel , Aubertin Michel
Published: April 2023

Tailings impoundments are often prone to failure due to various causes related to complex loading conditions. For instance, tailings impoundments can fail during or after a seismic event, mainly because of the liquefaction of loose, cohesionless tailings. To improve the seismic stability of impoundments, the density of the tailings can be increased or waste rock inclusions (WRI) can be added in the impoundment. This paper presents the results of numerical analyses of the impoundments loaded with a variety of ground motions with different frequencies, scaled at two different levels of intensity representative of two mining regions of Eastern Canada. The results show that the conventional impoundments are subjected to medium to high displacements at the end of shaking; these show a high probability of rupture during the earthquake or in the post-seismic phase. Tailings densification can decrease the volume of liquefied tailings and displacements during the seismic phase but does not significantly reduce the probability of post-seismic failure. WRI can slightly reduce the volume of liquefied tailings, depending on the intensity of the motions, but the reinforcement reduces significantly the lateral displacements; impoundments with WRI show even better performances during the post-seismic phase. The use of WRI is deemed a good approach to ensure the seismic stability of tailings impoundments and reduce the risk of seismically induced failure.
Study of Intelligent Fire Identification System Based on Back Propagation Neural Network
Authors: Yu Shaopeng , Dong Liyuan , Pang Fengyuan
Published: April 2023

In order to detect and identify fire accidents accurately and efficiently, an intelligent fire identification system based on neural network algorithm is designed, which can overcome the shortcomings of single information, complex wiring, poor adaptability, etc. The characteristic extraction of sensors is adopted in the information layer to solve the problems in multi-sensor fusion. The fire data are transmitted to the main controller through LoRa wireless module and fused by back propagation neural network, which is self-learning and adaptive. The output of neural network and fuzzy inference with other factors are used for decision criteria to improve the identification accuracy. The common combustibles and various interference sources are selected for fire tests. The result shows that the detection accuracy is up to 100% and the false alarm rate is lower than 0.1%, meanwhile, the system has the advantages of fast response and high detection efficiency.
Investigation on Dielectric, Electric, and Magnetic Properties of (Epoxy Resin-Titanate-Oxide/Ferrite) Ternary Composites at Microwave Frequency
Authors: Arab T. , Delfouf R. , Khouni H. , Bouzit N. , Djouada D. , Martinez Jiménez J. P. , Bourouba N.
Published: April 2023

The RE-ST-FE and RE-BT-FE/FR composites have been prepared and characterized using time domain spectroscopy method in the [DC-12.5] GHz range. The dielectric, magnetic and electrical properties of the ternary composites have been investigated. In the RE-ST-FE composite, the dielectric permittivity (ε′) has been found to decrease from 9.25 to 3.70 with increase in FE concentration. While it has been observed that the electrical conductivity increases as the ST concentration increases reaching a value of 11.6 (mS/m) and shows a percolation behavior with (Vth = 26,9% ST). In the RE-BT-FE/FR composites, the magnetization hysteresis loops have been measured by vibrating sample magnetometer from −3 to +3 kOe. This has made it possible to have a maximum of saturation magnetization equal 29.3 emu.g−1 and the permeability value close to 1.9 with the RE-BT-FR composite which is considered higher than that of the other one. It was found that an increase in the (FE/FR) concentration increases the magnetic permeability, which is confirmed by the modified Lichtenecker law with error ratio less than 0.5%. The results of this study will undoubtedly yield new materials that can be used to miniaturize electronic components used in telecommunications systems, resonators, antennas and wave absorbers.
Open-Circuit Fault Detection in a Single Conductor Transmission Line Using TM0 Mode Launcher
Authors: Yadav Swati V. , Chittora Ashish
Published: April 2023

A novel surface wave (SW) launcher design for power line fault detection is presented in this paper. The launcher is capable of converting TE10 to TM0 mode and exciting SW signal at 5.5 GHz frequency with high efficiency, on a single conductor line. The average attenuation of 2 dB/m and front to back ratio of 19 dB are observed and verified by simulation and experiments. Effect of bend, nearby obstacles, and extra wire connection on SW propagation is also investigated by experiments, and corresponding S-parameter results are presented. The optimization of launcher design with dielectric window and conical back plate is also demonstrated. The proposed launcher is compact and lightweight and can be easily installed without damaging the conductor line. Close structure makes it capable of withstanding outdoor environmental conditions. Using this launcher, microwave signal can be efficiently transmitted and received over existing conductor lines such as live power lines, pipes, and HVAC ducts, and it can be used in applications such as power line communication, fault detection, and permittivity measurement.
Association between Advance Care Planning for Older Adults and Family Caregivers’ Sense of Security in Home Care Settings: A Prospective Cohort Study
Authors: Shinohara Masumi , Sakka Mariko , Yasaka Taisuke , Inagaki Asa , Fukui Chie , Noguchi-Watanabe Maiko , Igarashi Ayumi , Yamamoto-Mitani Noriko
Published: April 2023

Family caregivers’ sense of security benefits older adults who receive home care. Advance care planning (ACP) is reported to affect family caregivers’ experience positively, but it might differ depending on family caregivers’ kin relationships with the older adults. This study aimed to investigate whether ACP for older adults in home care settings is associated with family caregivers’ sense of security and whether such an association depends on the family caregivers’ status as spouses or adult children. Clarifying this association may offer practical support for implementing ACP while maintaining family caregivers’ sense of security. This study was part of a prospective cohort study in Japan. The participants were older adults who used home-visit nursing services, their family caregivers, and the nurses who cared for them, recruited through the professional associations of home care nurses across Japan. Family caregivers answered a sense of security questionnaire, and the nurses were asked whether ACP was conducted. Data were collected three times from nurses and twice from family caregivers over a three-month period from August 2019 to June 2020. Multivariate logistic regression analyses were performed to examine the association between ACP implementation and positive changes in the sense of security scores after three months. Data from 169 cases were analyzed; 28.1% of the family caregivers were men and 55.6% were spouses. ACP was performed in 53.8% of the cases. The multivariate analysis showed an interactive effect between ACP implementation and family caregivers’ kin relationships. For spouses, ACP was significantly associated with a positive change in their sense of security. For adult children, such an association was not found. Thus, ACP might have a positive effect on caregiving spouses’ sense of security. Adult child caregivers, who often have multiple responsibilities and have difficulties facing their parents’ physical decline, may need support in addition to ACP.
Chebyshev Distance Entropy Combined with TODIM Method in Lq-ROFS Multiattribute Group Decision Making
Authors: Wang Yangcan , Tang Xin , Pan Yutong , Cai Mingqian
Published: April 2023

Linguistic q-rung orthopair fuzzy numbers (Lq-ROFNs) are composed of a set of q-rung orthopair fuzzy numbers (q-ROFNs) with membership and nonmembership degrees of linguistic variables, which can be regarded as an extension of linguistic intuitionistic fuzzy numbers (LIFNs) and linguistic Pythagorean fuzzy numbers (LPFNs). Compared with LIFNs and LPFNs, Lq-ROFNs have a wider range of applicability because the value of q can have a wider range, thus allowing to handle more multiattribute group decision making (MAGDM) problems. Based on Lq-ROFS, this paper first proposes the Chebyshev distance metric, then develops the Chebyshev distance entropy for deriving objective solution of decision makers’ (DMs’) weight vector and attribute weight vector by combining the metric and entropy measure. The TODIM method has been widely valued by the society and has achieved good results in many MAGDM problems. Subsequently, the TODIM decision method in Lq-ROFS is presented and combined with the Chebyshev distance entropy model as a new decision method (CDE-TODIM) to solve the MAGDM problems. This method process is objective and direct and takes into account the decision maker’s preferences, and the decision results are more persuasive. Finally, the effectiveness and rationality of this MAGDM method are illustrated by a case as well as comparisons.
Transition to Virtual Care Services during COVID-19 at Canadian Pain Clinics: Survey and Future Recommendations
Authors: Borg Debono Victoria , Neumark Samuel , Buckley Norman , Zacharias Ramesh , Hapidou Eleni , Anthonypillai Jennifer , Faria Susy , Meyer Carrie-Lynn , Carter Thomas , Parker Nadia , Lau Brenda , Abreu Emmanuel , Duggan Scott , Bisson Etienne , Pierre Josie , Visca Regina , Poulin Patricia
Published: April 2023

Introduction. Due to the COVID-19 pandemic, healthcare centers quickly adapted services into virtual formats. Pain clinics in Canada play a vital role in helping people living with pain, and these clinics remained essential services for patients throughout the pandemic. This study aimed to (1) describe and compare the transition from in-person to virtual pain care services at Canadian pain clinics during the onset of the COVID-19 pandemic and (2) provide postpandemic recommendations for pain care services to optimize the quality of patient care. Materials and Methods. We used a qualitative participatory action study design that included a cross-sectional survey for data collection and descriptive analysis to summarize the findings. Survey responses were collected between January and March of 2021. The survey was administered to the leadership teams of 11 adult pain clinics affiliated with the Chronic Pain Centre of Excellence for Canadian Veterans. Responses were analyzed qualitatively to describe the transition to the virtual pain services at pain clinics. Results. We achieved a 100% response rate from participating clinics. The results focus on describing the transition to the virtual care, current treatment and services, the quality of care, program sustainability, barriers to maintaining virtual services, and future considerations. Conclusions. Participating clinics were capable of transitioning pain care services to the virtual formats and have in-person care when needed with proper safety precautions. The pandemic demonstrated that it is feasible and sustainable for pain clinics to have a hybrid of virtual and in-person care to treat those living with pain. It is recommended that moving forward, there should be a hybrid of both virtual and in-person care for pain clinics. Ministries of Health should continue to develop policies and funding mechanisms that support innovations aimed at holistic healthcare, interdisciplinary teams, and the expansion of clinics’ geographical reach for patient access.
Spontaneous Hepatic Rupture in a Pregnant Woman with Preeclampsia and HELLP Syndrome
Authors: Lam Nguyen Phuoc , Mai Anh Tuan , Pham Thanh Chi , Kieu Hieu Trung , Nguyen Hien Quang
Published: April 2023

Spontaneous hepatic rupture is a rare complication associated with preeclampsia and is characterized by hemolysis, elevated liver enzymes, and a low platelet count (HELLP syndrome), with a nonspecific clinical presentation and high mortality rate. We present the case of a 34-year-old primigravida woman in whom spontaneous hepatic rupture associated with HELLP syndrome was accidentally detected during cesarean delivery. The patient was successfully managed with liver packing and transcatheter arterial embolization, followed by plasmapheresis. Spontaneous hepatic rupture should be considered in any HELLP syndrome patient presenting with epigastric or right upper quadrant pain and early signs of hemodynamic instability. A multimodal approach can help achieve good clinical outcomes in patients with this rare presentation.
Banner Authorship Members from Priorities to Promote Participant Engagement in the Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network
Authors: Schuster Anne LR. , Crossnohere Norah L. , Bachini Melinda , Blair Cindy K. , Carpten John D. , Claus Elizabeth B. , Colditz Graham A. , Ding Li , Drake Bettina F. , Fields Ryan C. , Janeway Katherine A. , Kwan Bethany M. , Lenz Heinz-Josef , Ma Qin , Mishra Shiraz I. , Paskett Electra D. , Rebbeck Timothy R. , Ricker Charité , Stern Mariana C. , Sussman Andrew L. , Tiner Jessica C. , Trent Jeffrey M. , Verhaak Roel GW. , Wagle Nikhil , Willman Cheryl , Bridges John FP.
Published: April 2023

Banner authorship list
Supplementary Table S1 from Performance of Statistical and Machine Learning Risk Prediction Models for Surveillance Benefits and Failures in Breast Cancer Survivors
Authors: Su Yu-Ru , Buist Diana S.M. , Lee Janie M. , Ichikawa Laura , Miglioretti Diana L. , Bowles Erin J. Aiello , Wernli Karen J. , Kerlikowske Karla , Tosteson Anna , Lowry Kathryn P. , Henderson Louise M. , Sprague Brian L. , Hubbard Rebecca A.
Published: April 2023

Supplementary Table S1 shows the calibration assessment in a sensitivity analysis on LASSO and Elastic-net by enforcing the adjustment of the matching factor.
Supplementary Methods from Performance of Statistical and Machine Learning Risk Prediction Models for Surveillance Benefits and Failures in Breast Cancer Survivors
Authors: Su Yu-Ru , Buist Diana S.M. , Lee Janie M. , Ichikawa Laura , Miglioretti Diana L. , Bowles Erin J. Aiello , Wernli Karen J. , Kerlikowske Karla , Tosteson Anna , Lowry Kathryn P. , Henderson Louise M. , Sprague Brian L. , Hubbard Rebecca A.
Published: April 2023

Supplementary Methods show the detailed information of model fitting using the machine learning approaches in this work.
Supplementary Figure S3 from Performance of Statistical and Machine Learning Risk Prediction Models for Surveillance Benefits and Failures in Breast Cancer Survivors
Authors: Su Yu-Ru , Buist Diana S.M. , Lee Janie M. , Ichikawa Laura , Miglioretti Diana L. , Bowles Erin J. Aiello , Wernli Karen J. , Kerlikowske Karla , Tosteson Anna , Lowry Kathryn P. , Henderson Louise M. , Sprague Brian L. , Hubbard Rebecca A.
Published: April 2023

Supplementary Figure S3 shows ranking of variable importance plot for random forests and gradient boosting machines for surveillance benefit.
Supplementary Table S5 from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study
Authors: Karanth Shama D. , Akinyemiju Tomi , Walker Courtney J. , Yang Danting , Migliorati Cesar A. , Yoon Hyung-Suk , Hong Young-Rock , Washington Caretia J. , Lattimore Chayil , Fredenburg Kristianna M. , Braithwaite Dejana
Published: April 2023

Table S5a shows the Cox proportional hazards model for oral cavity cancer, stratified by race/ethnicity and socioeconomic status. Table S5b shows the Cox proportional hazards model for pharyngeal cancers, stratified by race/ethnicity and socioeconomic status.
Supplementary Figure S1 from Performance of Statistical and Machine Learning Risk Prediction Models for Surveillance Benefits and Failures in Breast Cancer Survivors
Authors: Su Yu-Ru , Buist Diana S.M. , Lee Janie M. , Ichikawa Laura , Miglioretti Diana L. , Bowles Erin J. Aiello , Wernli Karen J. , Kerlikowske Karla , Tosteson Anna , Lowry Kathryn P. , Henderson Louise M. , Sprague Brian L. , Hubbard Rebecca A.
Published: April 2023

Supplementary Figure S1 shows frequency of predictor inclusion in regression-based models for surveillance failure and benefit across imputed datasets.
Supplementary Table S4 from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study
Authors: Karanth Shama D. , Akinyemiju Tomi , Walker Courtney J. , Yang Danting , Migliorati Cesar A. , Yoon Hyung-Suk , Hong Young-Rock , Washington Caretia J. , Lattimore Chayil , Fredenburg Kristianna M. , Braithwaite Dejana
Published: April 2023

Table S4 shows the joint association between race/ethnicity and socioeconomic status and mortality.
Supplementary Table S2 from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study
Authors: Karanth Shama D. , Akinyemiju Tomi , Walker Courtney J. , Yang Danting , Migliorati Cesar A. , Yoon Hyung-Suk , Hong Young-Rock , Washington Caretia J. , Lattimore Chayil , Fredenburg Kristianna M. , Braithwaite Dejana
Published: April 2023

Table S2 shows demographic and clinical characteristics of patients with primary head and neck cancer by race/ethnicity with missing socioeconomic status.
Supplementary Table S1 from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study
Authors: Karanth Shama D. , Akinyemiju Tomi , Walker Courtney J. , Yang Danting , Migliorati Cesar A. , Yoon Hyung-Suk , Hong Young-Rock , Washington Caretia J. , Lattimore Chayil , Fredenburg Kristianna M. , Braithwaite Dejana
Published: April 2023

Table S1 shows descriptive statistics of primary head and neck cancer patients with survival time <12 Months by race/ethnicity.
Supplementary Figure S2 from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study
Authors: Karanth Shama D. , Akinyemiju Tomi , Walker Courtney J. , Yang Danting , Migliorati Cesar A. , Yoon Hyung-Suk , Hong Young-Rock , Washington Caretia J. , Lattimore Chayil , Fredenburg Kristianna M. , Braithwaite Dejana
Published: April 2023

Figure S2 shows cumulative incidence curves by socioeconomic status for the HNC-specific death by race/ethnicity.
Supplementary Figure S1 from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study
Authors: Karanth Shama D. , Akinyemiju Tomi , Walker Courtney J. , Yang Danting , Migliorati Cesar A. , Yoon Hyung-Suk , Hong Young-Rock , Washington Caretia J. , Lattimore Chayil , Fredenburg Kristianna M. , Braithwaite Dejana
Published: April 2023

Figure S1 shows flowchart of study participant selection.
Supplementary Table 6 from Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma
Authors: Wang Chen , Block Matthew S. , Cunningham Julie M. , Sherman Mark E. , McCauley Bryan M. , Armasu Sebastian M. , Vierkant Robert A. , Traficante Nadia , Talhouk Aline , Ramus Susan J. , Pejovic Nadja , Köbel Martin , Jorgensen Brooke D. , Garsed Dale W. , Fereday Sian , Doherty Jennifer A. , Ariyaratne Dinuka , Anglesio Michael S. , Widschwendter Martin , Pejovic Tanja , Bosquet Jesus Gonzalez , Bowtell David D. , Winham Stacey J. , Goode Ellen L.
Published: April 2023

Supplementary Table 6: Multivariate Modeling of Time to Recurrence/Death Among Studies with Gene Expression Data
Supplementary Table 5 from Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma
Authors: Wang Chen , Block Matthew S. , Cunningham Julie M. , Sherman Mark E. , McCauley Bryan M. , Armasu Sebastian M. , Vierkant Robert A. , Traficante Nadia , Talhouk Aline , Ramus Susan J. , Pejovic Nadja , Köbel Martin , Jorgensen Brooke D. , Garsed Dale W. , Fereday Sian , Doherty Jennifer A. , Ariyaratne Dinuka , Anglesio Michael S. , Widschwendter Martin , Pejovic Tanja , Bosquet Jesus Gonzalez , Bowtell David D. , Winham Stacey J. , Goode Ellen L.
Published: April 2023

Supplementary Table 5: Modeling of Time to Recurrence/Death Among Studies with Gene Expression Data, excluding data from Previously Published Participants
Supplementary Table 4 from Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma
Authors: Wang Chen , Block Matthew S. , Cunningham Julie M. , Sherman Mark E. , McCauley Bryan M. , Armasu Sebastian M. , Vierkant Robert A. , Traficante Nadia , Talhouk Aline , Ramus Susan J. , Pejovic Nadja , Köbel Martin , Jorgensen Brooke D. , Garsed Dale W. , Fereday Sian , Doherty Jennifer A. , Ariyaratne Dinuka , Anglesio Michael S. , Widschwendter Martin , Pejovic Tanja , Bosquet Jesus Gonzalez , Bowtell David D. , Winham Stacey J. , Goode Ellen L.
Published: April 2023

Supplementary Table 4: Multivariate Modeling of Methylation Signature Among Studies with Multiple Datatypes
Supplementary Figure 1 from Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma
Authors: Wang Chen , Block Matthew S. , Cunningham Julie M. , Sherman Mark E. , McCauley Bryan M. , Armasu Sebastian M. , Vierkant Robert A. , Traficante Nadia , Talhouk Aline , Ramus Susan J. , Pejovic Nadja , Köbel Martin , Jorgensen Brooke D. , Garsed Dale W. , Fereday Sian , Doherty Jennifer A. , Ariyaratne Dinuka , Anglesio Michael S. , Widschwendter Martin , Pejovic Tanja , Bosquet Jesus Gonzalez , Bowtell David D. , Winham Stacey J. , Goode Ellen L.
Published: April 2023

Supplementary Figure 1: Methylation Signature Approximation
Supplementary Table S4 from Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules
Authors: Shome Mahasish , Gao Weimin , Engelbrektson Anna , Song Lusheng , Williams Stacy , Murugan Vel , Park Jin G. , Chung Yunro , LaBaer Joshua , Qiu Ji
Published: April 2023

Supplementary Table S4 from Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules
Supplementary Table S2 from Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules
Authors: Shome Mahasish , Gao Weimin , Engelbrektson Anna , Song Lusheng , Williams Stacy , Murugan Vel , Park Jin G. , Chung Yunro , LaBaer Joshua , Qiu Ji
Published: April 2023

Supplementary Table S2 from Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules
Supplementary Figure S3 from Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules
Authors: Shome Mahasish , Gao Weimin , Engelbrektson Anna , Song Lusheng , Williams Stacy , Murugan Vel , Park Jin G. , Chung Yunro , LaBaer Joshua , Qiu Ji
Published: April 2023

Supplementary Figure S3 from Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules
Supplementary Table 5 from Risk of Renal or Urinary Related Hospitalization in Survivors of Childhood Cancer: Results from the French Childhood Cancer Survivor Study
Authors: Mansouri Imene , Schwartz Boris , Vu-Bezin Giao , Bejarano-Quisoboni Daniel , Fresneau Brice , El-Fayech Chiraz , Dufour Christelle , Bolle Stéphanie , Surun Aurore , Orbach Daniel , Allodji Rodrigue S. , Diallo Ibrahima , Demoor-Goldschmidt Charlotte , de Vathaire Florent , Haddy Nadia
Published: April 2023

Supplementary Table 5 shows the characteristics of the patients from the FCCSS between 2011 and 2018, according to their linkage status with the French National health insurance database.
Supplementary Figure S2 from Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules
Authors: Shome Mahasish , Gao Weimin , Engelbrektson Anna , Song Lusheng , Williams Stacy , Murugan Vel , Park Jin G. , Chung Yunro , LaBaer Joshua , Qiu Ji
Published: April 2023

Supplementary Figure S2 from Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules
Supplementary Table 1 from Risk of Renal or Urinary Related Hospitalization in Survivors of Childhood Cancer: Results from the French Childhood Cancer Survivor Study
Authors: Mansouri Imene , Schwartz Boris , Vu-Bezin Giao , Bejarano-Quisoboni Daniel , Fresneau Brice , El-Fayech Chiraz , Dufour Christelle , Bolle Stéphanie , Surun Aurore , Orbach Daniel , Allodji Rodrigue S. , Diallo Ibrahima , Demoor-Goldschmidt Charlotte , de Vathaire Florent , Haddy Nadia
Published: April 2023

Supplementary Table 1 shows the list of hospitalisation causes coded according to the International Classification of Diseases 10th revision (ICD-10) related to subsequent kidney and urinary hospitalisations.
Table S6 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Shared hypermethylated loci (P < 0.01) in solid breast tissue and breast milk with increasing BMI
Table S2 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Shared hypomethylated loci (P < 0.01) in solid breast tissue and breast milk with increasing reproductive age
Table S14 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Age association with DNA methylation of the 10 overlapping hypermethylated probes in solid breast tissue and breast milk that map to the TSS1500 region of SFRP2.
Table S12 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Age and parity associated alterations to DNA methylation in solid breast tissue adjusted only for cellular composition and adjusted for cellular composition and both age and parity, respectively
Table S11 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Shared hypomethylated loci (P < 0.01) in solid breast tissue and breast milk with increasing age
Table S1 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Shared hypermethylated loci (P < 0.01) in solid breast tissue and breast milk with increasing reproductive age
Figure S7 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Distribution of the estimated relative proportion of each component cell type in (A) solid breast tissue (n = 95) and (B) breast milk (n = 48) by subject family history of breast cancer. Component cell types include epithelial cells, endothelial cells, fibroblasts, adipocytes, B cells, CD4+ T cells, CD8+ T cells, monocytes, neutrophils, and NK cells. Bonferroni-corrected P values shown from two sample t-tests.
Figure S5 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Correlation between subject reproductive age (years) and estimated relative proportions of cells in solid breast tissue (n = 95). Component cell types include epithelial cells, endothelial cells, fibroblasts, adipocytes, B cells, CD4+ T cells, CD8+ T cells, monocytes, neutrophils, and NK cells.
Figure S4 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Correlation between subject BMI (kg/m2) and estimated relative proportions of cells in solid breast tissue (n = 95). Component cell types include epithelial cells, endothelial cells, fibroblasts, adipocytes, B cells, CD4+ T cells, CD8+ T cells, monocytes, neutrophils, and NK cells.
Figure S3 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Correlation between subject age (years) and estimated relative proportions of cells in solid breast tissue (n = 95). Component cell types include epithelial cells, endothelial cells, fibroblasts, adipocytes, B cells, CD4+ T cells, CD8+ T cells, monocytes, neutrophils, and NK cells.
Figure S2 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Estimated relative proportions of component cell types in the breast-specific reference library among an independent data set of isolated adipocytes from abdominal subcutaneous fat samples (n = 30, GSE58622).
Figure S14 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Epigenome-wide association analysis identifying CpG sites that are significantly differentially methylated with increasing (A) BMI in solid breast tissue and (B) pre-pregnancy BMI in breast milk, adjusted for estimated proportions of epithelial cells, endothelial cells, fibroblasts, adipocytes, monocytes, and neutrophils. (C) Overlap of identified hypermethylated and hypomethylated loci (P < 0.01) in solid breast tissue and breast milk.
Figure S12 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Epigenome-wide association analysis identifying CpG sites that are significantly differentially methylated with increasing reproductive age in (A) solid breast tissue and (B) breast milk, adjusted for estimated proportions of epithelial cells, endothelial cells, fibroblasts, adipocytes, monocytes, and neutrophils. Red dashed lines indicate a significance threshold of FDR < 0.05. (C) Overlap of identified hypermethylated and hypomethylated loci (P < 0.01) in solid breast tissue and breast milk.
Figure S11 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Authors: Muse Meghan E. , Carroll Connolly D. , Salas Lucas A. , Karagas Margaret R. , Christensen Brock C.
Published: April 2023

Epigenome-wide association analysis identifying CpG sites that are significantly differentially methylated in breast milk relative to solid breast tissue. (A) adjusting only for age and parity, (B) adjusting for age, parity, and estimated proportions of epithelial cells, endothelial cells, fibroblasts, adipocytes, monocytes, and neutrophils (C) adjusting for age, parity, and family history of disease, and (D) adjusting for age, parity, family history of disease, and estimated proportions of epithelial cells, endothelial cells, fibroblasts, adipocytes, monocytes, and neutrophils. Red dashed lines indicate a significance threshold of FDR < 0.05. (E) Enrichment analysis for differentially methylated loci (FDR < 0.05) in breast milk relative to solid breast tissue after adjustment for age, parity, and cellular composition.
Supplementary Table 1 from Serum Lipid Profiles and Cholesterol-Lowering Medication Use in Relation to Subsequent Risk of Colorectal Cancer in the UK Biobank Cohort
Authors: Yuan Fangcheng , Wen Wanqing , Jia Guochong , Long Jirong , Shu Xiao-Ou , Zheng Wei
Published: April 2023

Supplementary Table 1 shows the associations of total and LDL cholesterols with colorectal cancer risk among non-users of cholesterol-lowering medications, stratified by sex, cancer subsite and age at diagnosis.
Supplementary Table S4 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Table S4 shows baseline characteristics of all participants by cancer diagnosis.
Supplementary Table S2 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Table S2 shows covariates used in the present study.
Supplementary Table S1 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Table S1 shows ICD codes used for identification of cancer diagnosis in the UK Biobank.
Supplementary Figure S7 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S7 shows subgroup analyses for the association between glucosamine use and incidence of kidney cancer.
Supplementary Figure S5 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S5 shows subgroup analyses for the association between glucosamine use and incidence of colorectal cancer.
Supplementary Figure S4 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S4 shows subgroup analyses for the association between glucosamine use and incidence of breast cancer in female participants.
Supplementary Figure S19 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S19 shows subgroup analyses for the association between glucosamine use and incidence of all other cancer.
Supplementary Figure S18 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S18 shows subgroup analyses for the association between glucosamine use and incidence of skin cancer.
Supplementary Figure S17 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S17 shows subgroup analyses for the association between glucosamine use and incidence of endometrium cancer in female participants.
Supplementary Figure S16 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S16 shows subgroup analyses for the association between glucosamine use and incidence of other female cancer.
Supplementary Figure S14 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S14 shows subgroup analyses for the association between glucosamine use and incidence of hepatobiliary cancer.
Supplementary Figure S13 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S13 shows subgroup analyses for the association between glucosamine use and incidence of cervical cancer in female participants.
Supplementary Figure S12 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S12 shows subgroup analyses for the association between glucosamine use and incidence of thyroid cancer.
Supplementary Figure S10 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Authors: Li Fu-Xiao , Zhao Hou-Yu , Lin Teng-Fei , Jiang Yi-Wen , Liu Di , Wei Chang , Zhao Zi-Yi , Yang Zu-Yao , Sha Feng , Yang Zhi-Rong , Tang Jin-Ling
Published: April 2023

Supplementary Figure S10 shows subgroup analyses for the association between glucosamine use and incidence of pancreas cancer.