bluuebunny/crossref_metadata_2025 huggingface dataset:
P125 Local Pulse Wave Velocity in the Arterial Tree: Site Matters!
Authors: Arias Daimé Campos , Stergiopulos Nikos , Moliner Tania Rodríguez , Segers Patrick
Published: February 2024

Background

Several so-called loop-based methods, have been proposed to estimate local pulse wave velocity (PWV). However, previous studies have demonstrated inaccuracies in local PWV-estimates due to presence of reflections, which led to the proposition of a frequency-domain correction method [1]. The aim of this study is to assess the accuracy of PWV-estimates from different loop methods throughout the human arterial tree.

Methods

The output data of a validated one-dimensional (1D) model of the human systemic circulation [2] was used to simulate the physiological signals needed on the estimations of local PWV methods, and this for model settings representing a young and an aged individual (stiffness increased by factor 2). Local PWV by the PU-loop, ln(D)U-loop, ln(D)P-loop, QA-loop and the frequency-domain (PWV1-5) methods, were compared against the reference value obtained from the Bramwell-Hill equation.

Results

Figure 1 shows the deviation (%) of loop-based estimates of PWV and PWV1-5 from the reference. The PU-loop overestimates PWV by more than 20% for most arterial sites, while the ln(D)U- and QA-loop underestimate to the same extent at these same locations. The correction method performs acceptably well in most of the young configuration. Discrepancies increase significantly in the aged model configuration for every studied method (except the ln(D)P-loop method).

Conclusion

The accuracy of loop-based methods is highly dependent on the location where they are applied, and results should be interpreted with great caution. Best results were obtained for the reflection- insensitive ln(D)P-loop method, but this method does not really provide an alternative for the Bramwell-Hill equation.
P127 Graded Cuff Compression Protocol to Induce Retrograde Shear Produces Proportionate Increment in Regional Arterial Compliance in Human Peripheral Artery
Authors: Afreen Naaz , Chandran Dinu , Jaryal Ashok , Deepak Kishore , Roy Sitikantha
Published: February 2024

Background

External compression using pneumatic cuff inflation is a well-established model used to induce incremental changes in proximal retrograde flow and shear [1]. The mechanisms behind distal cuff compression leading to proximal increase in retrograde shear are not clear. We hypothesized that changes in regional arterial compliance due to external cuff compression lead to changes in pulse waveform and pulse wave reflections proximal to the cuff compression.

Methods

We calculated brachial-radial pulse wave velocity (br-PWV) as a measure of regional arterial compliance in the area undergoing external cuff compression. This was accomplished using simultaneous two-point applanation tonometry over the cubital fossa and the wrist (Figure 1), while pneumatic cuff compression at 25, 50, and 75 mmHg (3-minute compression, randomized order, separated by 5 minutes) was applied around the middle of the forearm in 9 healthy young subjects (27 ± 4 years). Br-PWV was calculated using foot detection of the pulse waveforms and brachial-radial distance.

Results

External cuff compression at 50 and 75 mmHg resulted in significant fall in br-PWV but not at 25 mmHg. Percentage change in br-PWV showed graded decrement with rise in pressure of external cuff compression (-1.16 ± 6.96 at 25 mmHg, -10.57 ± 3.80 at 50 mmHg and -35.59 ± 11.08; all comparisons p < 0.05).

Conclusion

External cuff compression leads to changes in regional arterial compliance, which possibly affect the pressure wave reflections and pressure waveform proximally, leading to changes in the blood flow pattern at the site.
P137 Reflections Revisited: Reinterpretation Required
Authors: Westerhof Berend , Westerhof Nico
Published: February 2024

Introduction

Pressure waveshape derived parameters such as the augmentation index are related to unfavourable cardiovascular events [1]. Wave reflections determine wave shape [2], however, several findings seem to contradict the current views. Current view. The arterial system can be modelled by a tube with a reflection site at the end: the heart sets up waves propagating down the system, reflecting at the end and returning to the heart after twice the travel time, i.e. aortic length over Pulse Wave Velocity (PWV).Data. Return time of the reflected wave is not inversely proportional to PWV [3]. Also, reflected waves appear to run downstream rather than to the heart [4]. These findings conflict with the current concepts.

Interpretation

At all locations in the arterial system, wave reflection is determined by the characteristic impedance of the supplying vessel and the input impedance of the downstream system. The input impedance results from a system of many arteries with multiple reflection sites [5]. Time delay between forward and reflected wave is mainly determined by the phase angle of the downstream impedance, and does not systematically increase or decrease with distance. This implies that the time difference between reflected and forward wave is not increasing towards the heart as assumed by the single-tube model. As a consequence, the return time of the reflected wave is not inversely proportional to PWV.

Conclusion

The single tube model should be abandoned as conceptual model as is does not explain the measured data. A frequency domain (impedance) model is required.
P142 Androgen Receptor Reduced Sensitivity is Associated with Cardiovascular Mortality in Men with Type 2 Diabetes - A 14-year Follow up Study
Authors: Heald Adrian , Yadegarfar Ghasem , Livingston Mark , Fachim Helene , Narayanan Ram Prakash , Lunt Mark , Siddals Kirk , Cortes Gabriela , Gibson Martin , Donn Rachelle , Anderson Simon , Hackett Geoff , Jones Hugh
Published: February 2024

Background

Hypogonadism associates with increased cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM) [1]. Increasing CAG repeat number within exon 1 of the androgen receptor gene associates with increased androgen receptor resistance/insulin resistance [2]. We here investigated the link between CAG repeat number and metabolic/cardiovascular outcomes in T2DM men.

Methods

We determined in a 14-year follow-up cohort of 274 T2DM Caucasian men in Salford UK, the association between baseline androgen status/CAG repeat number (determined by PCR followed by Sequenom sequencing) and metabolic trajectory plus mortality.

Results

Lower baseline testosterone was associated with higher Body Mass Index (BMI) (kg/m2) at 14-year follow-up: regression coefficient −0.30 (95% CI: −0.445 to −0.157), p = 0.0001 (total testosterone data) and higher HbA1c 2016. Higher baseline CAG repeat number associated with higher follow-up BMI in 2016 - each unit increase in CAG repeat associated with 0.43 increment in BMI 2016. At an average 14 year follow-up 55.8% of hypogonadal men had died vs 36.1% of eugonadal men (p = 0.001). 72% of deaths were from cardiovascular causes. There was a ‘u’ shaped relation between the number of CAG repeats and mortality such that 21–23 CAG repeats was associated with an up to 58% lower mortality rate than <21 CAG repeats and >23 CAG repeats (Figure 1). This was independent of baseline testosterone.

Conclusion

A higher number of CAG repeats at the testosterone receptor gene associates with higher future BMI/increased HbA1c. There was a ‘u’ shaped relation between CAG repeat number and mortality rate. CAG repeat number may become part of cardiovascular risk assessment in T2DM men.

CAG_cat
Mortality
Proportional mortality rate
Lower bound
Upper bound

≤20
40
43
32
53

21
12
24
13
39

22–23
28
50
36
64

>23
34
45
34
57
P148 The Administration of Green Tea Extract Improves Hemodynamic Parameters, Arterial Stiffness and Renal Function in Patients with Diabetic Nephropathy
Authors: Barocio Marycruz , Grover Fernando , Jiménez Mayra , Larios Mariana , Quezada Patricia , Trujillo Jhonatan , Cardona Ernesto , Cardona David , Ramos Carlos
Published: February 2024

Purpose/Background/Objectives

Type 2 Diabetes Mellitus (T2DM) is a disease characterized by macro and microvascular complications, particularly, coronary heart disease, cerebrovascular disease and nephropathy [1–4]. The green tea extract has shown an anti-inflammatory effect (2), so this nutraceutical could be an alternative adjuvant in the treatment of the patient with diabetic nephropathy (DN) [5–7]. To evaluate the effect of the administration of green tea extract on hemodynamic, arterial stiffness, metabolic and renal function parameters in patients with DN.

Design and Methods

It was a randomized, double-blind study performed in 28 patients with DN, 14 assigned to placebo and 14 green tea extract, 400 mg every 12 hours for 12 weeks. Hemodynamic and arterial stiffness parameters were determined with HEM-9000AI, VP1000 Omron and metabolic parameters and renal function with Erba XL-100 equipment.

Results

The group under green tea extract treatment had significant decrease in the systolic blood pressure (mmHg) compared to those under placebo (-4.3 ± 12.7 vs 5.4 ± 12.2), central pressure (mmHg) (-6.0 ± 13.4 vs 9.1 ± 14.4), pulse pressure (mmHg) (-3.5 ± 6.6 vs 3.3 ± 6.4), triglycerides (mg/dl) (-16.4 ± 46.7 vs 30.3 ± 35.9), creatinine (-1.3 ± 0.2 vs 0.1 ± 0.1) and GFR (ml/min/1.73 m2) [8] (6.2 ± 5.9 vs -7.7 ± 10.9).

Conclusion

The administration of green tea extract improves hemodynamic parameters, metabolic parameters and renal function in patients with DM2 and chronic kidney disease.
Factors associated with the utilization of health service facilities at Abeli community health center, Kendari city, southeast Sulawesi province, Indonesia, 2023
Authors: Yusuf Sabilu  , Ranny Nur Alda  , Rahman
Published: February 2024

Background: Abeli Community Health Center, Kendari City, has experienced fluctuating visits over the last few years. This research was conducted in the working area of the Abeli Health Center, Kendari City. The instability in the number of patient visits at the Abeli Health Center in Kendari City over the last few years is clearly illustrated. In 2019, the number of patients served by this Puskesmas reached 14,333 patients. However, there was a decrease in the number of patient visits in 2020, with 10,038 patients using the service. This condition continues in 2021, with only 9,388 patients utilizing puskesmas facilities. However, in 2022, there is expected to be a significant increase, with 12,356 patients accessing services at the Abeli Community Health Center. Objective: To determine the factors related to the utilization of health service facilities in the working area of the Abeli Coomunity Health Center, Kendari City in 2023. Method: This type of research is quantitative research with an observational analytical approach and a cross sectional research design. The sampling technique in this study used an accidental sampling technique with a total of 351 samples with the criteria of respondents who utilized the health service facilities at the Abeli Community Health Center, Kendari City in 2023. Results: The results of the study show that there is a relationship between confidence in health services (p value = 0.000), waiting time for health services (p value = 0.000), perception of health and illness (p value = 0.013) with the use of health service facilities, and there is no relationship between ownership of health insurance (p value = 0.139) and utilization of health service facilities in the working area of the Abeli Health Center, Kendari City. Conclusion: There is a relationship between confidence in health services, waiting time for health services, perception of health and illness and utilization of health service facilities and there is no relationship between ownership of health insurance and utilization of health service facilities in the Abeli Health Center Working Area, Kendari City in 2023, so the role of agencies health to increase intensive health promotion programs to provide information to the public about the importance of health care through the use of health service facilities.
Introducing the A-view endotracheal balloon in cardiac surgery: Guiding the surgeon
Authors: George Joh. Brandon Bravo Bruinsma  , Arno Pieter Nierich
Published: February 2024

Stroke is serious modus for death following cardiac surgery. For twothird it is contributed to unloosend particles from atherosclerotic plaques in the ascending aorta ending up in the brain. Using regular trans esophageal echocardiogram (TEE) does not provide adequate information of the distal ascending aorta due to air in the trachea (‘Blind Spot’). The quality of the distal ascending aorta is of great importance to the cardiac surgeon as the aorta is maltreated by inserting a cannula for connection to the heart-lung machine and clamping to provide a bloodless operation field. The mission ahead is to improve real-time diagnostic information of the distal ascending aorta before opening the chest and providing the surgeon the opportunity to execute safe and reliable care. By replacing air in the trachea for the A-View saline filled endotracheal balloon, crucial information is obtained during TEE-imaging of the fully anesthetized cardiac patient. With this information at hand, the anesthesiologist may guide the surgeon to execute the best and safest operation.
Novel coronavirus infection (COVID-19) — clinical recommendations
Authors: Zaitsev A. A.
Published: February 2024

The treatment of patients with a new coronavirus infection (COVID-19) is the cornerstone of practical healthcare. This is due to the widespread and unjustified use of antimicrobial drugs, the use of irrational antiviral therapy schemes. Also, the discussion regarding the use of systemic glucocorticosteroids and monoclonal antibodies continues to this day. In this publication, based on research data and own clinical observations, clinical recommendations for COVID-19 pharmacotherapy are presented.
Treatment of heart rhythm disturbances associated with SARS-CoV-2 infection with anti-inflammatory drugs
Authors: Sukmarova Z. N. , Zotkin E. G.
Published: February 2024

Publications regarding cardiac arrhythmias associated with the new coronavirus infection (COVID-19) focus primarily on the high prevalence and symptoms of this complication. We have not found any studies on the specific treatment of arrhythmias associated with SARS-CoV2, since a standard therapeutic approach is probably implied. This observation describes a series of cases of various cardiac arrhythmias that occurred against the background of acute COVID-19 and were treated with anti-inflammatory, but not antiarrhythmic drugs. The cases are united by the occurrence of acute SARS-CoV-2 infection, the connection of relapses with inflammation symptoms, as well as the effectiveness of therapy with the main classes of anti-inflammatory drugs. A narrative review of the literature provides the rationale for the inflammatory theory of arrhythmias and sets the stage for discussion about how to integrate differentially anti-inflammatory drugs into the treatment regimen of such patients.
TRANSFORMASI PHYGITAL MARKETING PADA UMKM MAKANAN CEPAT SAJI GUNA MENINGKATKAN OMZET PASCA PANDEMI
Authors: Young Calvin , Wulandari Sri Hariani Eko , Wardhanie Ayouvi Poerna
Published: February 2024

Penelitian tentang eBusiness (bisnis elektronik) berupa penggunaan teknologi digital untuk mengelola dan mengembangkan bisnis secara online terus berkembang. Salah satu trend terbaru penelitian di bidang ebusiness adalah dikembangkannya metode physical dan digital pada bidang pemasaran sebagai solusi tantangan ketidakpercayaan masyarakat karena penipuan online melalui visualisasi produk, dan lain sebagainya yang disebut Phygital Marketing. Tantangan ketidakpercayaan ini juga terjadi pada bidang makanan cepat saji yang telah mengimplementasikan strategi digital marketing. Salah satu UMKM Makanan cepat saji yang merasakan dampak Pandemi sehingga bangkrut, dan saat bangkit kedua kalinya dengan memasarkan produknya secara digital, ternyata harus menelan kebangkrutan lagi. Oleh sebab itu, fokus penelitian diarahkan pada UMKM makanan cepat saji agar mampu bangkit ke tiga kalinya dengan tujuan meningkatkan omzet dari 50 ribu per hari menjadi 1 juta per hari, melalui penerapan strategi transformasi fisik dan digital atau dikenal dengan phygital marketing. Transformasi Ebusiness ini melibatkan integrasi antara dimensi fisik dan digital dalam upaya mengembangkan bisnis. Dalam penelitian ini, metode phygital marketing digunakan sebagai pendekatan utama. Pendekatan ini mencakup rebranding bisnis, perbaikan fisik outlet, serta penerapan digital marketing melalui platform TikTok dan Instagram. Hasil implementasi strategi phygital marketing menunjukkan pencapaian yang luar biasa. Target omzet harian sebesar 1 juta berhasil terlampaui, dengan pendapatan mencapai Rp 85.817.000 per bulan. Investasi dalam digital marketing sebesar Rp 3.900.000 per bulan menghasilkan Return on Advertising Spend (ROAS) yang mengesankan, mencapai 2.200% atau setara dengan 22 kali lipat dari biaya yang dieluarkan untuk pemasaran.

 

Kata kunci: Ebusiness,Phygital Marketing, UMKM  Makanan Cepat Saji
REKOMENDASI KOMODITAS EKSPOR MENGGUNAKAN K-NEAREST NEIGHBOR
Authors: Sony Simare-mare  , Henry Pandia
Published: February 2024

Indonesia memiliki produksi komoditas yang beragam dan melimpah dengan nilai ekspor yang luar biasa, khususnya pada bidang agrikultur. Banyaknya komoditas yang tersedia, membuat para eksportir maupun calon ekportir mengalami kesulitan menentukan komoditas yang mempunyai potensi untuk diekspor. Karena itu dibutuhkan sebuah sistem pendukung keputusan yang dapat merekomendasikan komoditas ekspor dengan cepat, tepat dan akurat. Penelitian ini bertujuan untuk menerapkan algoritme machine learning untuk menentukan komoditas yang disarankan untuk diekspor ke negara tertentu. Data pada penelitian ini diambil dari website Trademap International Trade Center (ITC) menggunakan HS Code (Harmonized System). Data yang digunakan merupakan data eksport tahun 2017-2021 yang terdiri dari data transaksi, negara pengimpor, komoditas, nilai impor, jumlah impor, dan pertumbuhan nilai. Data yang dipilih berasal dari beberapa jenis komuditas seperti: sayuran, buah-buahan, rempah-rempah, umbi-umbian, tanaman aromatik, serta jenis daun dan dahan. Menggunakan sebuah model dengan algoritme K-Nearest Neighbors (KNN), penelitian ini mengelompokkan sebuah komoditas ke dalam kelompok rekomendasi rendah, sedang dan tinggi. Hasil pengujian menunjukkan KNN memiliki nilai accuracy tertinggi yaitu pada parameter K=1 dengan nilai accuracy 85.71%. Nilai accuracy terendah terdapat pada parameter K=7 dan K=9 dengan nilai 78.57%. Peneliti berhasil menerapkan metode K-Nearest Neighbor untuk rekomendasi komoditas ekspor berdasarkan nilai yang diimpor, pertumbuhan nilai tahunan, dan jumlah yang diimpor. Penelitian dapat memberikan rekomendasi komoditas agrikultur yang bisa mempermudah para eksportir, maupun calon eksportir untuk memilih komoditas yang tepat untuk diekspor.

 

Kata Kunci: Euclidean Distance, K-Nearest Neighbor, Komoditas Ekspor, Rekomendasi
San Elías, enlace en la cadena escultórica de dos artistas
Authors: Murguía Meca Mercedes , Madrid Alanís Yolanda
Published: February 2024

En este ESCAPARATE se reflexiona sobre la producción de la imaginería novohispana, que implica la suma de la talla más el policromado, teniendo como eje la escultura de San Elías, del templo de Nuestra Señora de la Asunción, en Tlapanaloya, Estado de México; que fuera la primera de un grupo de cinco imágenes restauradas en el Seminario-Taller de Restauración de Escultura Policromada (STREP) de la Escuela Nacional de Conservación, Restauración y Museografía (ENCRyM) del Instituto Nacional de Antropología e Historia (INAH), las cuales llevaron a la identificación de un entallador español y un pintor: Pedro de Requena y Francisco de Gamboa o De Ibía, mejor conocido como De Zumaya. El conjunto se consideró, en los términos que propuso Paul Philippot, una unidad. _____ In this SHOWCASE, considerations are made regarding the production of the novohispanic imagery, implying the combination of the carving and the polychrome, which uses as an axis the sculpture of San Elías, from the temple of Nuestra Señora de la Asunción (Our Lady of the Assumption), Tlapanaloya, State of Mexico. First of a group of five images restored in the Seminario-Taller de Restauración de Escultura Policromada (STREP, Seminar-Workshop of Polychrome Sculpture Restoration) from the Escuela Nacional de Conservación, Restauración y Museología (ENCRyM) of the Instituto Nacional de Antropología e Historia (INAH), which led to the identification of a carver and a painter from Spain: Pedro de Requena y Franciso de Gamboa o De Ibía, better known as De Zumaya. The collection was adressed, in the terms proposed by Paul Philippot, as a unit.
The Effectiveness of Physical Exercise on Level of Symptom and Quality of Life in Primary Dysmenorrhea in Adolescent in Denpasar
Authors: Ni Luh Nopi Andayani  , Ari Wibawa  , Indah Pramita  , Suhita Apsari Pradnyandewi  , Govinda Vittala
Published: February 2024

Background: young women often experience various problems including pain during menstruation. Menstrual pain which is called dysmenorrhea is pain in the stomach or uterus, pain that occurs together with the onset of menstruation which occurs several hours to days. The incidence of primary dysmenorrhea will influence and have a major impact on the quality of life of these adolescents.

Purpose: This study aims to prove the effectiveness of physical exercises in the form of abdominal stretching and core strengthening in reducing the degree of complaints and the quality of life of young women with primary dysmenorrhea in Denpasar

Method: Research method with one pre-test design and post-test group design. The research was conducted at a private physiotherapist in Denpasar, Bali from September to August 2022. The sample consisted of 30 people who received physical exercises in the form of abdominal stretching and core strengthening.

Results: The Wilcoxon Test showed different results before and after the intervention obtained a value (p <0.05) which means that there was a significant difference before and after the intervention in the degree of complaints and quality of life.

Conclusion: Physical exercise is effective on the degree of complaints and quality of life in adolescents with primary dysmenorrhea in Denpasar
Correlation Analysis of Self-Concept and Interpersonal Communication Among Generation Z Nursing Students at Pre-Professional Nursing Practice
Authors: Paramitha Dewi Setya , Amaliah Noor , Ariadi Herman
Published: February 2024

Background: Interaction between people is facilitated by communication. The self concept might take on a positive or negative form. Gen Z is unique among current generations. Not just for the social structure they have come up in, but also for their spending habits, which differ from other generations. Objective: to investigate the possible relationship between generation Z nursing students' interpersonal communication skills and their self concept. Methods: A cross-sectional approach to correlation analysis was used in the research technique. The instruments were questionnaires and observations. The research sample consisted of 70 seventh semester preprofessional nursing students from Banjarmasin, selected using a total sampling technique. The Spearmen Rank Correlation test was utilized in this investigation. Results: indicated that 95.7% of students exhibited a good self concept, whereas 78.6% of students had intermediate levels of interpersonal communication abilities. The statistical test results showed a significant link (p < 0.05) between nursing students' self concept and their interpersonal communication skills. Conclusion: Students have a positive self concept, but clinical practice experience and social media influence their interpersonal communication skills. Suggestion: It is necessary to develop a program to improve both the positive nursing student’s self concept and teaching learning methods suitable for Z generation nurses to their communication abilities.
IDENTIFYING PANDEMIC ERA CONSUMER TRENDS: SENTIMENT ANALYSIS OF SOCIAL MEDIA POSTS
Authors: DURMUŞ ŞENYAPAR Hafize Nurgül
Published: February 2024

The COVID-19 pandemic has significantly impacted consumer purchasing habits and lifestyles. This study analyzes 1,500 posts from Instagram, YouTube, and Facebook and found a transition towards online shopping and digital service engagement, focusing on convenience and safety. Positive sentiments were prevalent, indicating consumer acceptance and adaptation to new norms. Health and safety concerns were heightened, focusing on sanitizers, masks, and health supplements. Financial strategies were reevaluated, leading to increased budget-consciousness and a preference for essential goods over luxury items. Travel and leisure restrictions led to a preference for local and at-home alternatives, such as staycations and local tourism. Remote work and online education also emerged, suggesting a longer-term transformation in work and learning environments. Consumer commitment to sustainability and ethical consumption increased, with support for local businesses and eco-friendly products. This study offers insights into the evolving consumer psyche and foresight into lasting consumer behavior changes.
Analyzing land cover change dynamism through a GIS-based method: application to Gran Canaria (Canary Islands, Spain)
Authors: Santana Cordero Aarón Moisés
Published: February 2024

Landscapes are dynamic areas which can be studied from the perspective of different, but related, disciplines. The application of GIS methods to study landscape change is an interesting resource to help understand and explain landscape dynamics. Thus, the objective of this paper is to characterize land cover dynamism and identify land cover change ‘hotspots’. The method used here generates raster maps in which each pixel value represents the number of times each pixel has changed land cover between 1990-2018. Furthermore, it provides three of these maps, since it works with the 3 taxonomic levels of Corine Land Cover datasets, giving us different levels of detail in the analysis. On the other hand, the statistical treatment of the data has been done at the municipal level. The most important results reveal that Agüimes is the municipality with the most dynamic land cover change in the three levels, while Tejeda, in level 1, and Valsequillo, in levels 2 and 3, have the least changing land cover. These outputs are complemented with other statistical analyses which allow the integration of different data types such as those related to population, tourism and agriculture. Subsequently, some of the methodological issues and findings are discussed and put in context with the scientific literature.
Formulasi Mouthwash Dari Daun Ketapang(Terminalia catappa L) Dengan Metode Infundasi
Authors: Larasati Dwi , Eko Kurniantoro Ferli , Arviani  , Shefty Destari Linda
Published: February 2024

Ketapang (Terminalia catappa L) memiliki kemampuan sebagai obat alami dengan senyawa metabolit sekunder berperan sebagai antibakteri. Senyawa yang  terkandung  pada tanaman ini berperan untuk  anti jamur dan antibakteri   degan kandungan yaitu alkaloid, flavonoid, tanin, saponin dan asam fenolik. Penelitian ini bertujuan memformulasikan sediaan mouthwash daun ketapang dengan metode infundasi. Formula mouthwash daun ketapang dibuat dengan tiga konsentrasi yaitu 12,5%, 25% dan 50%. Dalam penelitian ini, berbagai konsentrasi mouthwash daun ketapang diuji untuk mengukur kestabilan sifat fisiknya, termasuk pH, homogenitas, organoleptis, dan viskositas. Hasil penelitian terhadap uji organoleptis sediaan berbentuk larutan, rasa manis diikuti rasa menthol dan beraroma daun ketapang.. Sediaan homogen jernih dan tidak terbentuk endapan. Hasil uji pH sediaan pada rentang 5-7. Hasil penelitian menunjukkan bahwa sediaan mouthwash dari daun ketapang pada kontrol negatif menunjukkan  kestabilan dalam uji viskositas, pH, homogenitas, dan organoleptis. Meskipun, pada konsentrasi yang berbeda, hasilnya bervariasi, tetapi tetap menunjukkan kestabilan dalam uji organoleptis, homogenitas, dan pH.
Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian Di Puskesmas Jabon Kabupaten Jombang
Authors: Hariyani Hariyani , Sandra Vinda Aprillia
Published: February 2024

Pelayanan Kefarmasian di Puskesmas merupakan satu kesatuan yang tidak terpisahkan dari pelaksanaan upaya kesehatan, yang berperan penting dalam meningkatkan mutu pelayanan kesehatan bagi masyarakat. Kepuasan pasien merupakan salah satu tujuan dari peningkatan mutu pelayanan kesehatan. Terpenuhinya standar dalam pelayanan kefarmasian diharapkan dapat memenuhi harapan pasien. Penelitian ini bertujuan untuk mengetahui tingkat kepuasan pasien terhadap pelayanan kefarmasian di Puskesmas Jabon Kabupaten Jombang. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Teknik sampling yang digunakan adalah purposive sampling dengan jumlah sampel 270 responden yang memenuhi kriteria inklusi. Pengumpulan data yang dilakukan pada bulan Mei dengan membagikan kuesioner kepada responden yang telah mendapatkan pelayanan kefarmasian. Berdasarkan hasil penelitian yang diperoleh dilihat dari 5 dimensi terdiri dari dimensi responsivenes dengan hasil persentase 73,58%, dimensi emphaty dengan hasil persentase 74,94%, dimensi assurance dengan hasil persentase 72,96%, dimensi reliability dengan hasil persentase 76,98%, dimensi tangibles dengan hasil persentase 70,73%. Sehingga persentase rata-rata tingkat kepuasan pasien terhadap pelayanan kefarmasian di Puskesmas Jabon Kabupaten Jombang berada pada kategori puas dengan persentase 73,46%.
Adición de Leopardus Wiedii (Carnívora: Felidae) a la mastofauna de la provincia de Corrientes (Argentina)
Authors: Chatellenaz Mario L. , Zaracho Elba M. , Anchetti José L. , Villordo María G. , Azcarate Alejandro G.
Published: February 2024

El margay Leopardus wiedii es un pequeño félido que se distribuye desde México hasta norte de Uruguay. En Argentina contaba con registros solo en las provincias de Salta, Jujuy y Misiones. Aunque había sido mencionado nominalmente para la provincia de Corrientes, no existían evidencias de su presencia. Presentamos aquí los primeros registros documentados de la especie en la provincia de Corrientes, obtenidos entre 2012 y 2019. Estos hallazgos permiten adicionar a L. wiedii al ensamble de carnívoros de Corrientes, y extienden su distribución 65 km al sur de la localidad más próxima conocida en Misiones, constituyendo así los registros más meridionales conocidos en Argentina.
The Leadership and Friendship King of George VI in The King’s Speech Movie by Tom Hooper
Authors: Ayu Puspita Mega Nurmalisa , Lapasau Merry
Published: February 2024

This study aims to describe in detail and clearly the leadership style of King George VI and the value of his friendship with the therapist, Lionel Logue in the film The King's Speech. The object of this research is the film The King's Speech, which generally tells the story of King George VI who stuttered in speaking. This research method is descriptive qualitative. The analysis in this study uses Roland Barthes' semiotics through two stages of significance, namely denotation and connotation. By observing the scenes in the film. The results of this study indicate and describe that King George VI has a team leadership style on a scale of 9.9 and the value of friendship between King George VI and his therapist has met the proper values, namely understanding, honesty, trust, cooperation and loyalty.
Analysis of The Implementation of Interdisciplinary Learning in Improving Students’ English Speaking and Writing Skill
Authors: Simanjuntak Renyta Elfrida , Saragih Gustaman
Published: February 2024

The aims of this research: 1. To describe in detail the implementation of Interdisciplinary learning. 2. To describe the planning of implementation, 3. To describe the process of Interdisciplinary between English and Economy , 4. To describe the assessment done 5.To describe in detail the students’ achievements as the effect for Speaking and Writing skills .The population is class X of SMA Lentera Harapan Curug. The sample is 35 and the method is descriptive research, and it is a case study. The results show: 1. The interdisciplinary implemented is multidisciplinary because it is suitable for the high school. 2.The interdisciplinary learning planning is at the beginning of the semester. 3.The implementation consists of preliminary, core, and closing activities. 4.The assessment facilitated an authentic to assess the cognitive, psychomotor, and affective domains.
5.The implementation developed students writing and speaking skills that can be seen from the student’s achievement which is in good score.
Representation of Indonesian Millennials in The Presidential Election in The Mass Media (Critical Discourse Analysis Approach to an article in The Jakarta Post)
Authors: Basri Mauril , Rohmah Oom
Published: February 2024

The present study investigates the representation of Indonesian millennials in the 2019
presidential election in the mass media. How the media portray the millennials in news media becomes the purpose of this research. Qualitative research is employed to analyze the data. The data itself is taken from a news article from the Jakarta Post, “Millennials could be key to the election if they vote.” The tool used to analyze the written text is the critical analysis discourse proposed by Van Dijk (2011) and Fairclough (2005). It is found that millennials in the news article view millennials as an object. Their roles have not been explored deeply to see their potential in developing better political life. Millennials are urgently needed only for the sake of their voices and votes not their contribution to the politic itself.

 
CRESCIMENTO INICIAL DE PLANTAS TRIGO TRATADAS COM Trichoderma harzianum L.
Authors: Vey Rosana Taschetto , Cadore Luana da Silva , Bortolin Gabriel Streck , Fulaneti Fernando Sintra , Ferreira Matheus Martins , Silva Antonio Carlos Ferreira da
Published: February 2024

O objetivo deste trabalho foi avaliar a germinação de sementes de trigo tratadas com produtos biológicos à base de Trichoderma harzianum (Produto 1 e Produto 2), bem como, o crescimento inicial das plantas. No experimento um avaliou-se a germinação das sementes de trigo BRS 374, sob diferentes doses do Produto 1, sendo os tratamentos: T1- Tratamento controle (ausência do Produto 1), e os demais tratamentos nas seguintes doses de Produto 1/kg-1 de sementes, T2 - 1,11 mL, T3- 2,22 mL; T4- 3,33 mL e T5- 4,44 mL. No experimento dois avaliou-se a promoção da germinação, emergência, comprimento de raiz e área da raiz, comprimento de parte aérea e massa de matéria seca de plântulas, utilizando Produto 1 e Produto 2, sendo os tratamentos: T1- controle (ausência de trichoderma), T2- 1,11 mL de Produto 1, T3- 2,22 mL de Produto 1, T4- 1,2 g de Produto 2, T5- 1,0 g de Produto 2, T6- 0,80 g de Produto 2 e T7- 0,60 g de Produto 2 (doses para 1000 g de semente). Nas doses testadas, Produto 1 e Produto 2 aumentaram o comprimento de folhas, bem como proporcionaram maior área, comprimento e volume de raízes de trigo.
CRESCIMENTO E FISIOLOGIA DE TRÊS GENÓTIPOS DE PALMA FORRAGEIRA CONSORCIADOS COM LEGUMINOSAS E IRRIGADOS COM ÁGUA DE REÚSO
Authors: Souza José Thyago Aires , Araújo Jucilene Silva , Félix Evaldo dos Santos , Alves Rita de Cássia , Oliveira Filho Tarcísio José de , Lira Elder Cunha de , Medeiros Geovergue Rodrigues de , Batista Fabiane Rabelo da Costa
Published: February 2024

A palma forrageira se destaca como base alimentar de rebanhos ruminantes, principalmente em períodos de estiagem, comum no Semiárido. O seu cultivo consorciado com leguminosas e irrigado com água de reúso pode trazer ganhos quantitativos e qualitativos. Nesse sentido, objetivou-se avaliar o crescimento, fisiologia e produtividade de cladódios de palma forrageira irrigados com água de reúso e consorciados com leguminosas. O delineamento experimental consistiu em blocos casualizados com parcelas subdivididas, com três variedades de palmeiras em cada parcela: Miúda, Baiana e Orelha de Elefante Mexicana e nas subparcelas, quatro leguminosas: algaroba, sabiá, cunhã e gliricídia e sabiá, Além de um tratamento testemunha (sem consórcio). As variáveis altura e largura da planta, número de cladódios por planta, condutância estomática, taxa de transpiração, taxa de absorção de CO2, concentração interna de CO2, eficiência instantânea do uso da água e eficiência instantânea da carboxilação foram determinadas na palma forrageira. A variedade Miuda foi maior em altura, largura de planta e número de cladódios por planta. Quando não consorciadas, ambas as variedades de palma forrageira apresentaram maiores taxas de transpiração. O consórcio com algaroba, gliricídia e sabiá aumentou a absorção de CO2, a eficiência instantânea do uso da água e a carboxilação da palma forrageira, independente da variedade.
CONHECIMENTO E ADESÃO ÀS PRÁTICAS DE BIOSSEGURANÇA POR PROFISSIONAIS DE SAÚDE NO BRASIL: UMA REVISÃO INTEGRATIVA
Authors: Rodrigues Hemily dos Santos , Lisboa Ramon Batista de , Peixoto Magna Galvão , Kameo Simone Yuriko
Published: February 2024

O objetivo dessa revisão integrativa é descrever o nível de conhecimento e o grau de adesão dos profissionais de saúde brasileiros acerca das condutas de biossegurança e de sua importância no ambiente de trabalho. A pesquisa foi realizada entre agosto de 2021 a agosto de 2022 utilizando as bases de dados LILACS, BVS e PUBMED. Os estudos foram selecionados com auxílio de critérios de inclusão e exclusão pré-definidos e a coleta dos dados se deu por meio de um instrumento de coleta validado. Foram selecionados 14 artigos para a revisão, e a partir deles quatro temáticas de discussões surgiram: 1) Conhecimento e adesão aos Equipamentos de Proteção Individual (EPIs); 2) Conhecimento e adesão às medidas de higiene das mãos; 3) Conhecimento e adesão aos programas de vacinação; 4) Principais justificativas para o desconhecimento e a não adesão às medidas de biossegurança. Com base nos achados, foi possível observar que os profissionais brasileiros possuem níveis de conhecimento insatisfatórios em todas as áreas analisadas, e isso reflete diretamente na adesão aos protocolos e condutas de biossegurança que também se mostraram deficiente. Fatores como ausência de qualificação continuada, deficiência no fornecimento de instrumentos de biossegurança e fluxo de atendimento intenso e apressado foram também apontados como dificultadores da adesão.
DINÂMICA DE GASTOS EM OPERAÇÕES HUMANITÁRIAS PELAS FORÇAS ARMADAS BRASILEIRAS
Authors: Barino Raphael Sepulveda , Cunha Claudia Brito da , Tavares Sérgio Luís
Published: February 2024

A constante recorrência de crises humanitárias gera uma crescente demanda por intervenção por parte das Forças Armadas. Isto decorre do fato dos militares demonstrarem capacidades operacionais e características organizacionais necessárias para alcançar os objetivos das operações humanitárias: o alívio do sofrimento humano e a restauração da estabilidade do ambiente afetado. O financiamento e a manutenção das Forças Armadas são responsabilidade do governo federal, com recursos alocados no orçamento da Defesa, permitindo que cada Força administre os recursos de acordo com suas necessidades. Motivados pela carência de estudos que quantifiquem os custos das operações militares em ações subsidiárias, este artigo se concentra na análise da participação do Brasil por meio de suas Forças Armadas em diferentes missões humanitárias, examinando os dados orçamentários alocados para essa missão. Observou-se que, mesmo com a existência da Lei de acesso à informação, a divulgação detalhada do orçamento ainda apresenta lacunas, o que dificulta a contabilização precisa dos custos associados à atuação brasileira nessa missão e, por extensão, em operações humanitárias em geral.
ROBUSTAS AMAZÔNICOS: QUALIDADE DO CAFÉ DE RONDÔNIA
Authors: Lopes Junior Hilton , Rocha Rodrigo Barros , Kolln Alana Mara , Alves Enrique Anastácio , Teixeira Alexsandro Lara
Published: February 2024

Chamados de Robustas Amazônicos, os cafeeiros cultivados na Amazônia Ocidental se distinguem por apresentar características híbridas entre as variedades botânicas Conilon e Robusta. Na literatura encontramos informações dispersas sobre características agronômicas, físicas e químicas deste cafeeiro. Neste sentido, este estudo de revisão teve por objetivo realizar levantamento bibliográfico sobre as principais características agronômicas, químicas e de qualidade da bebida destas plantas. Trata-se de uma revisão integrativa, sendo que a escolha do assunto justifica-se pela necessidade de uma síntese que considere o conhecimento produzido sobre este tema nos últimos anos. Por meio desta revisão foi possível chegar algumas conclusões sobre a qualidade da bebida dos robusas amazônicos, (i) a genética do material plantado e a localidade influenciam nas características dos grãos dos robustas amazônicos cultivados em Rondônia  (ii) não foram observadas correlações entre o tamanho dos grãos com a qualidade da bebida, (iii) a presença em concentrações elevadas de ácido clorogênico e caveol pode ser um fator determinante para o aumento da qualidade sensorial, (iv) o beneficiamento e o processamento dos frutos de café em seu estado cereja é de suma importância para a obtenção de um café de qualidade, elevando a percepção de descritores por provadores Q-graders. A identificação de compostos associados a qualidade da bebida abre a possibilidade de desenvolvimento de marcadores que podem ser utilizados na seleção de novas plantas. No entanto, também observa-se que estudos mais aprofundados devem ser realizados para confirmar tais informações, pois a interação genótipo x ambiente tem sido observada na expressão da qualidade da bebida neste cafeeiro.
Retrospective Analysis of Molecular Markers in Endometrial Cancer: Single Center Experience
Authors: Ozdemir Cem Yagmur , Arioz Dagistan Tolga , Cicekli Nayif , Chkhikvadze Mariam , Bilir Filiz , Ozdemir Cigdem , Demir Hacer , Soylemez Evrim Suna Arıkan
Published: February 2024

Background: To emphasize the effect of molecular markers on prognosis in endometrial cancer, in addition to the International Federation of Gynecology and Obstetrics (FIGO) 2009 classification. Methods: The records of 160 patients with endometrial cancer between 2008 and 2022 were retrospectively reviewed. Staging was done according to FIGO 2009 criteria. Patients were divided into 4 groups according to molecular classification. If one had polymerase epsilon (POLE) mutation, the patient was included in POLE ultramutated (POLEmut) group. In case of intakt POLE, but abnormal staining of mismatch repair (MMR), the group was diagnosed as mismatch repair defciency (MMRd). If there was only p53 abnormal results detected, that group was p53-abnormal (p53mut). If no mutation at all, that group was categorized as non-specific molecular profile (NSMP). The Kaplan-Meier method was used to evaluate overall survival and progression-free survival. Survival rates were compared for molecular markers. Results: According to the molecular analysis, 4 patients (2.5%) were classifed as POLEmut group, 53 patients (33.1%) in the MMRd group, 18 patients (11.3%) had p53mut, and 85 patients (53.1%) into the NSMP group. 5-year overall survival was 79.4%, 5-year progression-free survival was 90%. 5-year overall survival was 75% in POLEmut group, 84.9% in MMRd group, 38.9% in p53mut group and 84.7% in NSMP group (p = 0.001). 5-year progression-free survival was 100% in POLEmut group, 96.2% in MMRd group, 77.8% in p53mut group and 88.2% in NSMP group (p = 0.082). Conclusion: Our study shows the prognostic value of the molecular endometrial cancer classification. Patients with p53mut have a poor progression-free survival, POLEmut endometrial cancer have a good prognosis. In this study, we wanted to demonstrate the importance of molecular markers in endometrium cancer and their contribution to prognosis.
Comparison of Oncological and Surgical Outcomes of Robot-Assisted, Laparoscopic Modified Radical Hysterectomy and Laparotomy for Endometrial Cancer
Authors: Ishikawa Masako , Nakayama Kentaro , Razia Sultana , Yamashita Hitomi , Ishibashi Tomoka , Kanno Kosuke , Sato Seiya , Kyo Satoru
Published: February 2024

Background: This study aimed to compare the oncologic and surgical outcomes of patients treated with robot-assisted modified radical hysterectomy (RAMRH) and total laparoscopic modified radical hysterectomy (TLMRH) for endometrial cancer (EC) with those of patients treated with abdominal modified radical hysterectomy (AMRH). Methods: We performed a retrospective analysis of 133 patients with early-stage EC who underwent different surgical approaches (RAMRH, n = 14; TLMRH, n = 94; AMRH, n = 25) between 2018 and 2021 at Shimane University Hospital. The data on clinical outcomes, including estimated blood loss, duration of surgery, duration of hospital stay, and number of dissected lymph nodes were collected from the patients’ electronic medical records. Kaplan–Meier curves were used to plot survival data, and log-rank tests were used to determine the statistical significance of differences in survival rates. Results: RAMRH showed the lowest bleeding volume (RAMRH: 95 ± 123.21 mL; TLMRH: 140.74 ± 172.60 mL; AMRH: 482.6 ± 429 mL) and shortest hospital stay (RAMRH: 6.43 ± 1.09 days; TLMRH: 7.30 ± 3.39 days; AMRH: 9.88 ± 2.65 days) among the three groups. The number of dissected lymph nodes tended to be higher in the RAMRH group than that in the TLMRH or AMRH group. The different surgical approaches did not correlate with progression-free survival and overall survival. Conclusions: Both RAMRH and TLMRH are safe, feasible, innovative, and minimally invasive surgical alternatives to AMRH for patients with EC.
Identification of a Serum Exosome-Derived lncRNA‒miRNA‒mRNA ceRNA Network in Patients with Endometriosis
Authors: Huang Yan , Zhang Deyu , Zhou Yingfang , Peng Chao
Published: February 2024

Background: Endometriosis (EM), a gynecological disorder that is dependent on estrogen and causes inflammation, is prevalent among women of reproductive age and is considered a chronic condition. The involvement of noncoding RNAs in exosomes is crucial for the progression of EM. This study aimed to determine exosomal microRNA (miRNA) biomarkers in EM. Methods: Exosomes were isolated and characterized from the plasma of patients with EM and controls. Exosomal miRNA was sequenced using microarrays. EM-related differential miRNAs (DE-miRNAs) were identified using analysis of differential miRNA expression and weighted coexpression network analysis. The common pairs of long noncoding RNA (lncRNA)-miRNA and miRNA-mRNA were determined. Cytoscape was used to establish the regulatory network of characteristic genes known as competitive endogenous RNA (ceRNA), and the hub miRNAs, hub mRNAs, and hub lncRNAs were identified. Results: We isolated plasma exosomes from 10 control and 10 EM patients. We obtained a total of 50 DE-miRNAs, consisting of 7 miRNAs that were upregulated and 43 miRNAs that were downregulated. A network of ceRNA regulation was constructed using the diagnostic miRNAs, which revealed a total of 36 lncRNAs, 20 miRNAs, and 264 mRNAs associated with EM. Additionally, 10 lncRNAs (GAS5, MALAT1, FGD5-AS1, HCG18, SNHG16, XIST, OIP5-AS1, NEAT1, KCNQ1OT1, and SNHG12), 10 miRNAs (hsa-miR-361-5p, hsa-miR-19b-3p, hsa-let-7f-5p, hsa-miR-23a-3p, hsa-miR-199a-3p, hsa-miR-18a-5p, hsa-miR-221-3p, hsa-miR-17-5, hsa-miR-27a-3, and hsa-miR-25-3p), and 10 mRNAs (GALC, ETNK1, RNF4, SOX4, ZBTB18, SPRY2, RUNX1, MYLIP, BTG2, and MAP2K4) were identified as hub molecules. Conclusions: Thirty plasma exosomal miRNA markers associated with endometriosis were identified and reported. The miRNAs were associated with the promotion of proliferation in mesenchymal cells, as well as the tumor necrosis factor (TNF) and Toll-like receptor signaling pathways, and the differentiation of T helper 1 (Th1) and Th2 cells. These biological processes and pathways could potentially play a significant role in the pathogenesis and progression of EM. The potential clinical value of these miRNAs indicates potential targets for diagnosing and treating endometriosis while also offering new insights into the molecular mechanisms of the disease.