bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase I/II multicenter study of ABI-009 (nab-sirolimus) combined with FOLFOX and bevacizumab as first-line (1L) therapy in patients (pts) with metastatic colorectal cancer (mCRC) with or without PTEN loss.
Authors: Sharma Sunil , Becerra Carlos Roberto , Matrana Marc Ryan , Alistar Angela Tatiana , Chiorean E. Gabriela , Schmid Anita Nagypal , Grigorian Berta , Hou Shihe , Desai Neil
Published: January 2019

TPS730

Background: Very few treatment options are available for pts with mCRC beside the standard of care (SOC), 5-FU based chemotherapy + bevacizumab. Immunotherapy is an option for pts with microsatellite instability (~5% of mCRC). The central role of the PI3K/mTOR pathway in cancer biology, including CRC, suggests that mTOR inhibition along with chemotherapy may improve antitumor activity in the metastatic setting. A recent phase I/II study showed promising antitumor activity of everolimus + SOC as 1L treatment for mCRC (96% progression-free [PF] rate at six months at the maximum tolerated dose (MTD), and 86% ORR for pts with PTEN loss (Gilcrease, ASCO 2012). The goal of this prospective, single arm phase I/II study is to evaluate the efficacy and safety of ABI-009, a novel mTOR inhibitor, + SOC as 1L treatment for mCRC. Methods: Eligible pts have an ECOG performance status of 0-2 and histologically confirmed measurable metastatic disease. PTEN loss (by IHC) and mutational status for PIK3CA, KRAS, NRAS, BRAF by NGS is evaluated for all pts. ABI-009 is given weekly x3 every four weeks starting at 30 mg/m2and can escalate to 45 and 60 mg/m2 (3+3 design); mFOLFOX6 + bevacizumab is given every two weeks. After six cycles of therapy, cycles may change to 21-days: ABI-009 weekly x2 every three weeks and mFOLFOX6 + bevacizumab every three weeks. Pts are treated until disease progression. Tumor response is assessed by CT at baseline then every eight weeks for one year, then every 12 weeks thereafter. Phase I will enroll up to 18 pts; the primary endpoints are dose-limiting toxicities and MTD, secondary endpoints include disease control rate (DCR). Phase II will enroll 40 pts; the primary endpoint is PF rate at six months, and secondary endpoints are median PF survival, overall survival, duration of response, and DCR in the intent-to-treat population and based on PTEN status. This study is now active, with first pt enrolled. The anticipated enrollment period is 12 months. This prospective phase I/II study may show evidence of efficacy and safety of ABI-009 combined with the SOC in pts with mCRC with or without PTEN loss to warrant a larger clinical study. Results: N/A. Conclusions: N/A. Clinical trial information: NCT03439462.
Phase II study of avelumab in combination with cetuximab in pre-treated RAS wild-type metastatic colorectal cancer patients: CAVE (cetuximab-avelumab) Colon.
Authors: Troiani Teresa , Martinelli Erika , Ciardiello Davide , Zanaletti Nicoletta , Cardone Claudia , Borrelli Carola , Avallone Antonio , Falcone Alfredo , Maiello Evaristo , Bordonaro Roberto , Santini Daniele , Garufi Carlo , De Braud Filippo G. , Pinto Carmine , Gridelli Cesare , Ciardiello Fortunato
Published: January 2019

TPS731

Background: The immune system plays a crucial role in modulating response to monoclonal antibodies therapy in cancer. Novel immunecheckpoint inhibitors have demonstrated potent efficacy alone and in combinations with cytotoxic agents in several cancers. In this regard, avelumab in combination with cetuximab might be a relevant rechallenge strategy in RAS wild-type (WT) metastatic colorectal cancer (mCRC) patients treated in first-line with chemotherapy (CT) in combination with anti-EGFR drugs and who achieved a complete or partial response. Methods: CAVE Colon is a single arm, multi-center phase II study designed to evaluate the efficacy of avelumab and cetuximab in pre-treated RAS WT mCRC patients. Eligible patients: pathologically confirmed RAS WT mCRC treated with a first-line CT in combination with an anti-EGFR agent with a major response achieved (complete or partial), who have progressed to a second line therapy, and received no prior immunotherapy. Primary endpoint is overall survival, secondary endpoint are overall response rate according to RECIST 1.1, progression free survival and safety profile. The current study seeks to demonstrate a median OS of 11 months (alternative hypothesis) by the experimental combination for comparison with historical median OS 8.0 (null hypothesis) with standard third line treatments, which correspond to an improvement of OS at six months from 40% to 57%. It was estimated that it would be needed to enroll 66 patients to achieve a 80% power with a one-sided 5% level test. The accrual period will be 18 months and the total duration of the study will be 36 months. Considering a potential drop-out of approximately 15% of patients, a total of 75 patients will be recruited. Seven patients have been enrolled and started treatment to date (September 15, 2018) with avelumab 10 mg/kg q14 as a one-hour i.v. infusion and cetuximab at 400 mg/m2 over two-hour and subsequently 250 mg/m2 q 14 as one-hour i.v. infusion until disease progression or unacceptable toxicity. EudraCT number: 2017-004392-32. This study is partially supported by Merck KgA, Darmstadt, Germany. Results: N/A. Conclusions: N/A. Clinical trial information: EudraCT number: 2017-004392-32.
High Preponderance of BRAF V600E Mutation in Papillary Thyroid Carcinoma Among Filipinos: A Clinicopathologic Study
Authors: Espiritu Gerard Anthony M. , Malana Joemari T. , Dumasis Arlie Jean Grace V. , Ang Daphne C.
Published: January 2019

Purpose

BRAF mutation in papillary thyroid carcinoma (PTC) is associated with an aggressive phenotype, with varying incidence. We evaluated the prevalence of BRAF mutations in PTC among Filipino patients and their correlation with clinicopathologic characteristics.

Patients and Methods

Clinicopathologic data were retrieved from 64 sequential patients who underwent thyroidectomy from June 2016 to December 2016. BRAF mutation testing was performed using Sanger sequencing.

Results

Eighteen (28%) of 64 patients were diagnosed with PTC; 12 (70.59%) of 17 harbored a BRAF V600E mutation (no amplification in one patient). Demographics of patients with PTC were as follows: 13 women and five men, with median age of 46 years (range, 25 to 74 years). Fourteen patients had conventional subtype PTC; two, follicular variant; one, oncocytic variant; and one, tall-cell features. Tumor size ranged from 0.8 to 7.0 cm (median, 2.4 cm); extrathyroidal extension was present in seven (38.9%) of 18 patients, multifocality in six (33.33%) of eight, and lymph node involvement in eight (44.4%) of 18. Significant association between presence of a BRAF mutation and presence of extrathyroidal extension or lymph node involvement was not determined due to the limited sample size.

Conclusion

The high preponderance of BRAF mutation (70.59%) suggests some correlation with the previously reported lower 5-year survival among Filipinos. This warrants further investigation in a larger-cohort prospective study.
Cervical Cancer Treatment Delays and Associated Factors in a Cohort of Women From a Developing Country
Authors: Ferreira da Silva Ileia , Ferreira da Silva Ilce , Koifman Rosalina Jorge
Published: January 2019

PURPOSE

To estimate treatment delays and associated factors among women diagnosed with cervical cancer who were treated at the main cancer center in Rio de Janeiro, Brazil.

MATERIALS AND METHODS

A retrospective cohort study was performed comprising 865 women newly diagnosed with cervical cancer between 2012 and 2014. Times from diagnosis to treatment initiation (less than or equal to 60 days) and from diagnosis to treatment ending (less than or equal to 120 days) were analyzed according to the Brazilian law for the treatment of patients with cancer. Associations between treatment delays and sociodemographic, economic, lifestyle, clinical, and treatment variables were estimated using logistic regression models, with 95% CIs.

RESULTS

The average age was 48 (± 13.7) years, and the median age was 47 years; 36.2% of patients had stage IIIB to IVA disease. The median time from diagnosis to treatment initiation was 114 days, which was statistically higher among women with stage IIB to IVA (105.5 days) compared with those with earlier stages (119 days). The delay in treatment initiation occurred in 92.8% of participants; the median time from diagnosis to treatment ending was 274 days, with a delay (more than 120 days) for 92.6% of patients. The median time interval from diagnosis to the first visit to the cancer center was 28 days, with a delay of more than 30 days for 46.6% of patients. Age (odds ratio [OR], 1.05; 95% CI,1.02 to 1.08), stage IIIB to IVA (OR, 0.38; 95% CI, 0.16 to 0.90), time to first visit to the cancer center (OR, 11.52; 95% CI, 4.32 to 30.66), chemoradiation treatment (OR, 4.56; 95% CI, 1.81 to 11.47), and adequate treatment (OR, 2.57; 95% CI, 1.26 to -5.40) were independently associated with delay of treatment initiation.

CONCLUSION

Significant delays in treatment initiation and ending were observed in this studied population. The treatment initiation delay was positively associated with age, time interval more than 30 days from diagnosis to first specialist assessment at the cancer center, treatment with chemoradiation, and adequate treatment.
Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics
Authors: Wang Hong-Hui , Zhang Yu , Tang Feng , Pan Meng-Hao , Wan Xiang , Li Xiao-Han , Sun Shao-Chen
Published: January 2019

Cytoskeletal dynamics are involved in multiple cellular processes during oocyte meiosis, including spindle organization, actin-based spindle migration and polar body extrusion. Here, we report that the vesicle trafficking protein Rab23, a GTPase, drives the motor protein Kif17, and that this is important for spindle organization and actin dynamics during mouse oocyte meiosis. GTP-bound Rab23 accumulated at the spindle and promoted migration of Kif17 to the spindle poles. Depletion of Rab23 or Kif17 caused polar body extrusion failure. Further analysis showed that depletion of Rab23/Kif17 perturbed spindle formation and chromosome alignment, possibly by affecting tubulin acetylation. Kif17 regulated tubulin acetylation by associating with αTAT and Sirt2, and depletion of Kif17 altered expression of these proteins. Moreover, depletion of Kif17 decreased the level of cytoplasmic actin, which abrogated spindle migration to the cortex. The tail domain of Kif17 associated with constituents of the RhoA-ROCK-LIMK-cofilin pathway to modulate assembly of actin filaments. Taken together, our results demonstrate that the Rab23-Kif17-cargo complex regulates tubulin acetylation for spindle organization and drives actin-mediated spindle migration during meiosis.
Fairness and Frictions: The Impact of Unequal Raises on Quit Behavior
Authors: Dube Arindrajit , Giuliano Laura , Leonard Jonathan
Published: January 2019

We analyze how separations responded to arbitrary differences in own and peer wages at a large US retailer. Regression-discontinuity estimates imply large causal effects of own-wages on separations, and on quits in particular. However, this own-wage response could reflect comparisons either to market wages or to peer wages. Estimates using peer-wage discontinuities show large peer-wage effects and imply the own-wage separation response mostly reflects peer comparisons. The peer effect is driven by comparisons with higher-paid peers—suggesting concerns about fairness. Separations appear fairly insensitive when raises are similar across peers—suggesting search frictions and monopsony are relevant in this low-wage sector. (JEL D63, J31, J42, J62, L81)
Financing Durable Assets
Authors: Rampini Adriano A.
Published: January 2019

This paper studies how the durability of assets affects financing. We show that more durable assets require larger down payments making them harder to finance, because durability affects the price of assets and hence the overall financing need more than their collateral value. Durability affects technology adoption, the choice between new and used capital, and the rent versus buy decision. Constrained firms invest in less durable assets and buy used assets. More durable assets are more likely to be rented. Economies with weak legal enforcement invest more in less durable, otherwise dominated assets and are net importers of used assets. (JEL D25, G31, G32, O31)
The Social Value of Financial Expertise
Authors: Kurlat Pablo
Published: January 2019

I study expertise acquisition in a model of trading under asymmetric information. I propose and implement a method to measure r, the ratio of the marginal social value to the marginal private value of expertise. This can be decomposed into three sufficient statistics: traders’ average profits, the fraction of bad assets among traded assets, and the elasticity of good assets traded with respect to capital inflows. I measure r = 0.16 for the junk bond underwriting market. Since this is less than 1, it implies that marginal investments in expertise destroy surplus. (JEL D82, G11, G14, G21, L84)
When Britain Turned Inward: The Impact of Interwar British Protection
Authors: de Bromhead Alan , Fernihough Alan , Lampe Markus , O’Rourke Kevin Hjortshøj
Published: January 2019

International trade collapsed, and also became much less multilateral, during the 1930s. Previous studies, looking at aggregate trade flows, have argued that trade policies had relatively little to do with either phenomenon. Using a new dataset incorporating highly disaggregated information on the United Kingdom’s imports and trade policies, we find that while conventional wisdom is correct regarding the impact of trade policy on the total value of British imports, discriminatory trade policies can explain the majority of Britain’s shift toward Imperial imports in the 1930s. (JEL F13, F14, F54, N74)
Spatio-temporal patterns based on demographic and genetic diversity of the purple sea urchin Paracentrotus lividus in the area around Corsica (Mediterranean Sea)
Authors: DUCHAUD SOPHIE , DURIEUX ERIC D.H. , COUPE STEPHANE , PASQUALINI VANINA , TERNENGO SONIA
Published: January 2019

Sea urchins were harvested for decades in many areas throughout its distribution range, potentially leading to population collapse. In France, the purple sea urchin Paracentrotus lividus is intensively harvested. Yet, the demography and population dynamics remained under-documented, particularly in Corsica. In this context, we have characterized the fluctuations in density of several size classes at 8 sites around the island, and assessed the genetic diversity and structuring of the population. Densities recorded lie between 0 and 2.18 (± 0.41) individuals.m-2 and spatio-temporal variabilities have also been highlighted. The study of the influence of vegetation cover on the size classes suggests that small- and medium- sized individuals prefer substrates of intermediate heights, whereas individuals with a diameter ≥ 5 cm are more often observed on encrusting substrates, and may be responsible for the continuation of this type of benthic community. The genetic study indicates a high genetic diversity with a low genetic structuring. The Ne values obtained are similar to those described in previous papers. Due to estimates of local contemporary Ne and the homogeneous genetic diversity, our data tend to show that the Corsican population of P. lividus is not overexploited.
Seasonal and bathymetric effects on macrofouling invertebrates’ primary succession in a mediterraenan non-indigenous species hotspot area
Authors: LEZZI MARCO , GIANGRANDE ADRIANA
Published: January 2019

The present study investigates macrofouling development in the Mar Grande of Taranto (Central Mediterranean Sea), a wide confined area that has attracted considerable attention in recent years due to the establishment of numerous non-indigenous species (NIS). Different starting times of a yearly primary succession on artificial substrates were tracked so as to investigate the matching of the development pattern with contingency and/or convergence models, identifying NIS’s structural role in the community endpoint. Our results show that during the experiment all assemblages tended to converge towards multiple contingent communities according to starting times and depths. The differences are due to propagule availability which influence further species interactions. Thus the endpoint patterns are defined by a contingent community development determined by the seasonal species pool, their phenologies, pre- and post-settlement events, and species interactions. The most important structuring species was Mytilus galloprovincialis, which was present in almost all the endpoint assemblages, in particular when it recruits at early stages of the community development. Another abundant species at the endpoint was the alien Branchiomma boholense; which was a persistent structural component contributing to an alternative state in which Mytilus galloprovincialis loses its structural importance and where B. boholense becomes dominant, leading to an increase in fouling biodiversity of the endpoint assemblage.
Seamounts as hot-spots of large pelagic aggregations
Authors: VASSALLO PAOLO , PAOLI CHIARA , ALESSI JESSICA , MANDICH ALBERTA , WÜRTZ MAURIZIO , FIORI CRISTINA
Published: January 2019

The distribution of four top predators in the Tyrrhenian Sea, a sub-basin of the Mediterranean Sea, was investigated by means of random forest regression considering depth, distance from the coast, seafloor slope, and distance from seamounts as habitat descriptors on a 2x2–nautical mile regular grid. RF results are processed to estimate variable importance and model performance. Random forest architecture reached optimal sensitivity and specificity, thus providing a consistent support tool for identifying suitable habitats. The considered species are characterized as having patched suitable habitats with a number of hot-spot areas where the different species’ habitats overlap. These hot-spot areas’ locations correspond to those of specific seamounts identifying the attraction effect of these topographic structures. The mean features typifying the most attractive seamounts are investigated and found to be shallow peak and base depths but wide base area and high relative elevation.
Redescription of the Mediterranean endemic parasitic isopod Anuropodione amphiandra (Codreanu, Codreanu & Pike, 1966) n. comb. (Crustacea: Isopoda: Bopyridae) from Munida rutllanti Zariquiey Alvarez, 1952, with new records from Turkey and a review of the genus Anuropodione Bourdon, 1967
Authors: BOYKO CHRISTOPHER B. , WILLIAMS JASON D. , ÖKTENER AHMET
Published: January 2019

Seven species of bopyrid isopods were previously known from Turkish Mediterranean waters; a purported eighth species, Orthione griffenis Markham, 2004, is based on incorrect identification and likely represent Epipenaeon ingens ingens Nobili, 1906, a species already known from the area. In the present study, we report on specimens referable to Pleurocrypta amphiandra Codreanu, Codreanu & Pike, 1966, infesting Munida rutllanti Zariquiey Alvarez, 1952, collected from the southern Aegean Sea off Turkey; this species was formerly known only from the Mediterranean off Algeria and the Adriatic Sea. The species is redescribed and illustrated for the first time and transferred to Anuropodione Bourdon, 1967, which is reviewed and A. australiensis Bourdon, 1976, is transferred to Allorbimorphus Bourdon, 1976. A key to all species of Anuropodione and a list of all bopyrids found on squat lobsters and porcelain crabs in the Mediterranean are provided.
Synthesis of adsorbent from food industry waste for purification of used cooking oil
Authors: Prabowo Sulistyo , Muflihah Muflihah
Published: January 2019

This study aimed to utilize food industry waste (i.e. banana (Musa paradisiaca L.) peel), as a raw material for making banana peel activated carbon (BPAC). The activated carbon-making process was conducted at varying temperatures (200, 400 and 600°C) and furnacing times (1, 2 and 3 hours). The purification function of the BPAC obtained from the optimization process was assessed with used cooking oil (UCO) from the food industry. The purified oil was tested for three quality parameters, the peroxide value, free fatty acid value and iodine value. The results of this testing showed that BPAC could slightly improve the quality of used cooking oil.
An in vitro model for studying CNS white matter: functional properties and experimental approaches
Authors: Bijland Silvia , Thomson Gemma , Euston Matthew , Michail Kyriakos , Thümmler Katja , Mücklisch Steve , Crawford Colin L. , Barnett Susan C. , McLaughlin Mark , Anderson T. James , Linington Christopher , Brown Euan R. , Kalkman Eric R. , Edgar Julia M.
Published: January 2019

The normal development and maintenance of CNS white matter, and its responses to disease and injury, are defined by synergies between axons, oligodendrocytes, astrocytes and microglia, and further influenced by peripheral components such as the gut microbiome and the endocrine and immune systems. Consequently, mechanistic insights, therapeutic approaches and safety tests rely ultimately on in vivo models and clinical trials. However, in vitro models that replicate the cellular complexity of the CNS can inform these approaches, reducing costs and minimising the use of human material or experimental animals; in line with the principles of the 3Rs. Using electrophysiology, pharmacology, time-lapse imaging, and immunological assays, we demonstrate that murine spinal cord-derived myelinating cell cultures recapitulate spinal-like electrical activity and innate CNS immune functions, including responses to disease-relevant myelin debris and pathogen associated molecular patterns (PAMPs).  Further, we show they are (i) amenable to siRNA making them suitable for testing gene-silencing strategies; (ii) can be established on microelectrode arrays (MEAs) for electrophysiological studies; and (iii) are compatible with multi-well microplate formats for semi-high throughput screens, maximising information output whilst further reducing animal use. We provide protocols for each of these. Together, these advances increase the utility of this in vitro tool for studying normal and pathological development and function of white matter, and for screening therapeutic molecules or gene targets for diseases such as multiple sclerosis, motor neuron disease or spinal cord injury, whilst avoiding in vivo approaches on experimental animals.
Modern Problems of Implementing Recruitment Functions in Russian Organizations (on the Example of Commercial Organizations in Moscow and the Moscow Region)
Authors: Белова О. , Belova O.
Published: January 2019

The article is devoted to the consideration of the leading trends in modern recruitment related to changes in views on the sources of efficiency, the development of strategic and marketing approach to staff, the active use of new principles, digital tools and methods. The results of the research of recruitment in the organizations of Moscow and Moscow region are summarized. The comparative analysis of the world and Russian trends in recruitment is given. The problems of the modern Russian recruitment complicating its development are allocated, necessity is shown and the main ways of its improvement are outlined.
Personnel Management in the Hotel Business: the Importance of Training
Authors: Кузина О. , Kuzina O. , Раденович М. , Radenovich M. , Ашурбеков Р. , Ashurbekov R.
Published: January 2019

The enterprises human assets or, put more conventionally, its human resources tend to be one the most significant costs for most hospitality enterprises. In most hotels the payroll is the single biggest cost item, whilst in restaurants and bars it is usually second only to material costs. A valet, cleaning personnel and restaurant servers have different requirement than check-in clerks, concierge providers and managers. Yet, the entire workforce is a reflection of a hotel’s hospitality culture, which is why everyone needs to be trained from top to bottom on certain specific values and standards. The effective management of these human resources is therefore vital to the success of the enterprise.
Preditores do adiamento da aposentadoria por servidores públicos federais
Authors: Soares Silva Macêdo Luciani , Bendassolli Pedro F , De Lucena Torres Tatiana
Published: January 2019

Este artigo examina a influência de fatores relacionados ao trabalho sobre a intenção de continuar trabalhando além do tempo obrigatório de contribuição. A pesquisa, de corte transversal, foi conduzida com 283 servidoresfederais brasileiros e envolveu a aplicação da validação brasileira da escala Older Worker´s Intention to Continue Working (OWICW) em um survey on-line. Osresultados indicaram que a maioria dos participantes quer continuar no trabalho remunerado. Análises de regressão logística múltipla apontaram como preditoresdessa intenção: percepção de autonomia pessoal, interação interpessoal, condições flexíveis de trabalho, além de interesses fora do trabalho. Quanto à decisãode adiar a aposentadoria e permanecer na organização, os fatores preditivos foram: percepção de autonomia pessoal, condições flexíveis de trabalho e o incentivofinanceiro (abono de permanência). Os resultados podem subsidiar políticas públicas e de gestão institucional sobre o processo de decisão trabalho-aposentadoria.Palavras-chave: adiamento da aposentadoria, significadodo trabalho, servidores públicos, recursos humanos,envelhecimento.
Uso problemático de internet en adolescentes españoles y su relación con autoestima e impulsividad
Authors: Moral Jiménez María de la Villa , Fernández Domínguez Sara
Published: January 2019

Dado el gran auge del uso de las nuevas tecnologías de la información y la comunicación (TIC) por parte del colectivo juvenil resulta de interés el análisis de los patrones disfuncionales y de su potencialidad adictiva. El objetivo de este trabajo consiste en explorar las relaciones entre el uso problemático de internet y factores de riesgo como la impulsividad, así como analizar las diferencias en conflictos intra e interpersonales asociados en función del género y la edad. Han participado 240 adolescentes y jóvenes (124 mujeres y 116 hombres) con edades comprendidas entre los 15 y 22 años (X= 18.075; DT= 2.36), estudiantes del Principado de Asturias (España). En relación con la posible existencia de usos problemáticos de internet resulta atribuible al 11.25% de los adolescentes frente a un 88.75% que muestran un uso controlado. Respecto a las diferencias en función del género y de la edad no han resultado significativas. Se ha hallado que la baja autoestima y la impulsividad cognitiva y no planeada predicen con mayor probabilidad el uso desadaptativo de internet. Presentar mayor propensión a tomar decisiones rápidas, así como mostrar más interés en las tomas de decisiones  presentes que futuras, aumentan las probabilidades de puntuar más alto en conflictos interpersonales asociados al uso problemático de internet. Se discuten las implicaciones de tales hallazgos.Palabras clave: uso problemático, Internet, autoestima, impulsividad, adolescentes.
Antisocial Behaviour: A Unidimensional or Multidimensional Construct?
Authors: Santos Walberto Silva dos , Holanda Leonardo Carneiro , Meneses Glysa de Oliveira , Luengo Mª. Angeles , Gomez-Fraguela Jose Antonio
Published: January 2019

This study aimed at evaluating the internal consistency of the Antisocial Behavior Questionnaire and analyze its factor structure. Specifically, it sought to evaluatethe suitability of one-factor and multifactorial models, and to verify the extent to which scores of antisocial behavior vary according to gender. We counted with twodifferent samples of school adolescents. They answered, among other measures, the Antisocial Behavior Questionnaire and demographic questions. The resultsindicated that the multidimensional model composed of five independent factors was more suitable than the one-factor model as well as the model with five factorsof first order and a higher order factor. The male participants had higher scores on aggression, theft, conduct against the rules and vandalism. No significantdifferences were found for problems with drug abuse. We conclude, therefore, that the antisocial behavior is adequately represented by a multidimensional structurecomprising acts of different types and gravities, and that these are more likely in males than females.Keywords: Antisocial behavior, dimensionality, factorialstructure, gender differences.
Mudanças na psicoterapia psicodinâmica de crianças na visão de pais e mães
Authors: Ramires Vera Regina Rohnelt , Carvalho Cibele , Gastaud Marina Bento , Oliveira Luiz Ronaldo Freitas de , Godinho Lucia Belina Rech
Published: January 2019

No campo da pesquisa em psicoterapia psicodinâmica das crianças, uma questão aberta é como avaliar sistematicamente as mudanças e quais se consideram fundamentais. Não se têm levado a cabo análises qualitativas acerca da visão de país e mães. O objetivo deste estudo foi investigar a percepção de pais e mãessobre as possíveis mudanças em suas crianças durante suas psicoterapias. O estudo teve enfoque qualitativo, descritivo, longitudinal. Os participantes foram país e mães de quatro crianças, assistidos na clínica privada por três  psicoterapeutas treinados em psicoterapia clínica.Eles responderam regularmente ao questionário de pergunta aberta que se centrou nas mudanças percebidasno curso do processo terapêutico. Os resultados mostraram que os pais têm identificado mudanças no curso da psicoterapia de seus filhos, que eles não eram lineais e não se limitaram à melhoria sintomática. Também se identificaram mudanças no funcionamento mental das crianças e sua adaptação à realidade, e nas relações interpessoais.Se discutiu a importância da participação dos pais na psicoterapia das crianças e o seguimento de sua visão acerca do processo terapêutico. Eles podem proporcionar feedbacks importantes que contribuem para o progresso do tratamento.Palabras-chave: psicoterapia psicanalítica, mudanças, crianças.
The Effect of Solution-Focused Brief Counseling on Reducing Test Anxiety
Authors: Altundağ Yunus , Bulut Sefa
Published: January 2019

Test anxiety is a very common phenomena observed in K-12 level of education all over the world. This can take a more complex and stressful form in countires uses national exam in university entrance. Turkey is one of those countries. Since higher education is free for all of the citizen, students have found themselves confronting a very competitive testing-culture. Therefore, the purpose of this study was to test the effectiveness of solution-focused brief counseling approch on test anxiety of senior year high school students. An experimental study was conducted in an Anatolian High School in Bolu, Turkey in the academic year of 2015-2016. Sixteen students were participated in the study, eight of them were in the experimental group, other eight were in the control group. The ages of the students varied between 16 and 18 years; the average age of the experimental group was 17, while it was 16.87 in the control group. Six of the participants were male whereas ten were female. Because the data set was not normally distributed and number of participatns was less than 30, nonparametic tests were prefered for data analysis.  Mann Whitney-U and Wilcoxon Signed Rank tests, which are nonparametric techniques, were utilized in data processing. The resuls revaled that the four-session individual psychological counseling based on solution-focused brief approach was effective in mitigating students' test anxiety. These findings were found to be consistent with the related literature.Keywords: Solution-Focused Brief approach, psychological counseling, test anxiety, adolescent, high school student, university entrance exam.
O sistema de cuidado e a relação médico-paciente: respondendo às necessidades do outro
Authors: Guerra Barstad Castro Neves Mariana , Oliveira Grillo Rafaela , Sollero-de-Campos Flávia
Published: January 2019

A teoria do apego afirma que os seres humanos têm em paralelo um sistema de apego, um sistema de exploratório e um sistema de cuidado. O sistema de cuidadoé a contrapartida dos sistemas de apego e exploratório. O sistema de cuidado consiste em proporcionar uma base segura à que o indivíduo pode regressar quando se sente ameaçado e uma base segura a partir da qual pode explorar o ambiente. O sistema de cuidado também pode ser experimentado na relação médico-paciente. Ser um profissional da saúde é estar disponível quandoé mais necessário. Os padrões de apego influenciam a relação do médico com o paciente, afetando a adesão ao tratamento e o manejo da doença. Cuidar de seuspacientes em momentos de necessidade é equivalente a ativar o próprio sistema de cuidado do médico para proteger e garantir a saúde e o bem-estar do paciente.Um médico aberto e disponível representa um paciente mais aberto, presente, seguro e confiado.Palavras-chave: teoria do apego, sistema de cuidado, base segura, relação médico-paciente..
Sensor Data and Behavioral Tracking: Does Usage-Based Auto Insurance Benefit Drivers?
Authors: Soleymanian Miremad , Weinberg Charles B. , Zhu Ting
Published: January 2019

Using individual driving behavior (from sensor data) and other information for UBI adopters, we estimate the relationship from being enrolled and monitored in the UBI program and changes in the driving behavior of UBI customers.
DO OLHAR PORTUGUÊS SOBRE MACAU: ALGUMAS REPRESENTAÇÕES POÉTICAS CONTEMPORÂNEAS
Authors: Nunes de Almeida Catarina
Published: January 2019

Macau ocupa até hoje um lugar ímpar na cultura portuguesa, configurando uma entidade simultaneamente histórica, literária, política e mítica. A poesia portuguesa contemporânea tem sido persistente em recuperar os termos da complexa relação que Oriente e Ocidente foram tecendo ao longo dos séculos e essa persistência permite-nos olhar para Macau não apenas como um território geográfico, mas como um conceito com uma considerável força simbólica. Podemos, em certa medida, entender a aproximação ao imaginário macaense como nostalgia do império, como esperança do encontro não só com um passado histórico, mas também literário (através de figuras como Luís de Camões, Camilo Pessanha ou Wenceslau de Moraes, com vivências ligadas àquele território). Alguns poetas escolhidos para este estudo trabalharam por alguns anos no território (José Alberto Oliveira, Gil de Carvalho ou Fernanda Dias), outros realizaram viagens por tempo mais limitado (Sophia de Mello Breyner Andresen, em 1977, a convite do Conselho da Revolução, onde iria tomar parte das celebrações do Dia de Camões; António Manuel Couto Viana, entre 1986 e 1988, a convite do Instituto Cultural de Macau, onde colaborou enquanto docente; e Eugénio de Andrade, em 1999, numa visita breve que resultaria anos mais tarde na obra Pequeno Caderno do Oriente, publicada em 2004). A evocação dum conjunto fixo de lugares (por exemplo, a Gruta de Camões ou o Jardim Lou Lim Ieoc), continuamente retomados pela escrita, resultou na cristalização duma cartografia literária associada a Macau, cujo mapeamento e a interpretação este estudo propõe.
Cartas & restos. Una historia soterrada entre Brasil e Hispanoamérica
Authors: Estupiñán Mary Luz
Published: January 2019

En este ensayo queremos proponer el estudio de la correspondencia entre escritores, escritoras, poetas, poetizas y artistas latinoamericanos para rastrear insumos que permitan establecer redes intelectuales entre Brasil e Hispanoamérica, en buena parte del siglo XX. Proponemos que este registro afectivo presenta vestigios para rearmar y tramar nuevas constelaciones en aras de suspender los relatos convencionales que cifran esta relación. Primero presentaremos algunos de los fundamentos que se han esgrimidos para explicar la lábil relación entre estas dos zonas culturales. Segundo, expondremos la importancia del estudio de la correspondencia para hallar otras claves de lectura. Y finalmente, enunciaremos algunas posibilidades que se pueden abrir desde este estudio.
Sobre o ensino de literatura brasileira e lusófonas nos Estados Unidos e França: depoimentos
Authors: Moriconi Italo , Garramuño Florencia
Published: January 2019

Depoimentos
Apresentação
Authors: Moriconi Italo , Garramuño Florencia
Published: January 2019

Apresentação
5 ways to transform… outdoor play
Authors: Mountain Julie
Published: January 2019

Make 2019 the year that you commit to transforming children's outdoor play, says Julie Mountain
Karl Marx and Rosa Luxemburg: Thought Legacy and Contemporary Value: A Review of the 13th Forum of the World Association for Political Economy
Authors: Ding Xiaoqin , Zhang Zhixun
Published: January 2019

This year is the 200th anniversary of Marx's birth. Marx's intellectual heritage has the most profound influences on the development of human society. Marxism has profoundly changed the historical process of human social development. As one of the most influential figures in the development of Marxist history, Rosa Luxemburg has important practical significance for the understanding of Marx's theoretical heritage. Her theoretical thoughts still have a profound significance for the study of Marxism today. In today's society, Marxism remains the most powerful ideological weapon of the proletariat, which points out the correct path for social progress and human liberation. Marxists should constantly conduct theoretical and practical explorations to realize human liberation and the development of socialism.
Gender expertise in global governance: contesting the boundaries of a field
Authors: Kunz Rahel , Prügl Elisabeth , Thompson Hayley
Published: January 2019

This article conceptualises gender expertise in global governance as a transnational field. We propose two theoretical shifts: a depersonalisation to understand expertise as a field rather than experts as individuals or a group of people; and a re-conceptualisation of expertise from a depoliticised body of knowledge towards expertise as a performative and intrinsically political practice. Drawing on qualitative data, we identify practices of boundary drawing and erasing to analyse three key cleavages of this field: contestations over the boundary between gender expertise and feminism; contestations over scientific epistemologies and authority; and contestations over the logics of (post-)colonial politics surrounding gender expertise.
Estimates of Within-Subject Biological Variation Derived from Pathology Databases: An Approach to Allow Assessment of the Effects of Age, Sex, Time between Sample Collections, and Analyte Concentration on Reference Change Values
Authors: Jones Graham Ross Dallas
Published: January 2019

BACKGROUND

Within-subject biological variation data (CVI) are used to establish quality requirements for assays and allow calculation of the reference change value (RCV) for quantitative clinical laboratory tests. The CVI is generally determined using a large number of samples from a small number of individuals under controlled conditions. The approach presented here is to use a small number of samples (n = 2) that have been collected for routine clinical purposes from a large number of individuals.

METHODS

Pairs of sequential results from adult patients were extracted from a routine pathology database for 29 common chemical and hematological tests. Using a statistical process to identify a central gaussian distribution in the ratios of the result pairs, the total result variation for individual results was determined for 26 tests. The CVI was then calculated by removing the effect of analytical variation.

RESULTS

This approach produced estimates of CVI that, for most of the analytes in this study, show good agreement with published values. The data demonstrated minimal effect of sex, age, or time between samples. Analyte concentration was shown to affect the distributions with first results more distant from the population mean more likely to be followed by a result closer to the mean.

DISCUSSION

The process described here has allowed rapid and simple production of CVI data. The technique requires no patient intervention and replicates the clinical environment, although it may not be universally applicable. Additionally, the effect of regression to the mean described here may allow better interpretation of sequential patient results.
A Personal Reflection on the 50th Year Anniversary of the Optometric Historical Society
Authors: Caplan Lester
Published: January 2019

Personal reflections of Dr. Lester Caplan, a founding member of the Optometric Historical Society, on his involvement during the course of his life and his career as a private practitioner in Baltimore, MD, as an academic at the University of Alabama, and his leadership in public health optometry at the local, state and federal level.
List of Meetings of the Optometric Historical Society and Speakers
Authors: Goss David A.
Published: January 2019

List of annual meetings of the Optometric Historical Society, including date, number in attendance, context  and speaker.
Thermal Stability and Reproducibility Enhancement of Organic Solar Cells by Tris(hydroxyquinoline)gallium Dopant Forming a Dual Acceptor Active Layer
Authors: Muhammad Fahmi F. , Sulaiman Khaulah
Published: January 2019

Nowadays, the main barriers facing organic solar cells (OSCs) from being commercialized and widely applied are their weak thermal stability and reproducibility problems. To tackle these problems, researchers usually consider various strategies which include modification in the devices architectural design, utilizing low energy gap materials, functionalizing their active layers, and the use of various optimization procedures. In this research work, we are specifically focused on the utilization of a small molecular organometallic, tris(hydroxyquinoline)gallium (Gaq3), as a secondary acceptor dopant, aiming at improving thermal stability, and reproducibility of OSCs. All-solution processed technique with the help of spin coater was used to deposit the active layer of the devices. Results showed that the addition of 29% molar fraction of Gaq3 into the devices active layer has considerably improved the thermal stability, photo-absorption, and reproducibly of the solar cells thanks to the excellent thermal stability and electron mobility of Gaq3 molecules. Our devices based on DH6T: PCBM:Gaq3 performed highest stable performance at 180°C, implying higher thermal stability compared to that of the reported P3HT: PCBM:F8BT and PTB7:PCBM: F8BT based solar cells. In spite of improved reproducibility, the efficiency of the devices was increased by 5.8 times compared to that of the control ones.
Pengaruh Aplikasi Streptomyces spp. Terhadap Penyakit Kuning, Pertumbuhan, dan Produksi Tanaman Cabai Besar
Authors: Putri Riska Awalia
Published: January 2019

Penyakit keriting kuning cabai yang disebabkan oleh Begomovirus merupakan salah satu kendala produksi cabai di Indonesia. Salah satu alternatif pengendalian penyakit ini menggunakan Plant Growth Promoting Rhizobacter (PGPR) yang diharapkan  dapat mengurangi penggunaan pestisida  yang berdampak buruk bagi lingkungan dan kesehatan. Penelitian ini bertujuan untuk mengetahui efektifitas Streptomyces spp. dalam menekan penyakit keriting kuning, pertumbuhan tanaman dan hasil panen cabai besar. Penelitian dilakukan di lahan petani di Desa Harjobinangun, daerah Pakem, Kabupaten Sleman, Yogyakarta. Menggunakan varietas cabai Twist dan  Isolat Streptomyces spp. koleksi Laboratorium Bakteriologi Tumbuhan dengan konsentrasi 108 CFU/ml. Hasil penelitian menunjukkan bahwa Streptomyces spp. mampu menurunkan  insidensi dan intensitas penyakit pada fase vegetatif 54,17% dan 59,06%. Sedangkan pada fase generatif 50% dan 65,92%. Streptomyces spp. dapat meningkatkan tinggi dan diameter tanaman  pada fase vegetatif 4,61% dan 6,05%. dan pada fase generatif 27,28% dan 1,11%. Streptomyces spp. dapat meningkatkan panjang akar, volume akar dan jumlah cabang produktif 4,40%, 20,70%, dan 24,81%. Streptomyces spp. dapat meningkatkan jumlah dan bobot total panen 15,5% dan 16,72%.  Streptomyces spp. dapat meningkatkan kualitas buah ditunjukan dengan peningkatan panjang, diameter, dan bobot buah  layak jual  6.26%, 12,80%, dan 11,39%.
Why Mathematical Probability Failed to Emerge from Ancient Gambling
Authors: Kidd Stephen
Published: January 2019

The emergence of mathematical probability has something to do with dice games: all the early discussions (Cardano, Galileo, Pascal) suggest as much. Although this has long been recognized, the problem is that gambling at dice has been a popular pastime since antiquity. Why, then, did gamblers wait until the sixteenth centuryceto calculate the math of dicing? Many theories have been offerred, but there may be a simple solution: early-modern gamblers played different sorts of dice games than in antiquity. While ancients diced at communal risk, early-moderns diced at individualized risk. These individual wager-games, for example, the game “hazard”, incentivized solving questions like “how likely is it to roll a triple-six?”. Before the early modern period there was no gambling game to which working out mathematical probability would have brought an advantage.
Equity Incentives and Crash Risk in China’s A-Share Market
Authors: Xu Jiahua
Published: January 2019

This paper examines the relationship between equity incentives and stock price crash risk in China’s A-Share Market, and finds a significantly positive relationship between equity incentives and crash risk. This result holds true when only executives’ incentives are involved, while the significance fades once non-managerial personnel’s incentives are considered, indicating a tendency for managers to manipulate the stock price when their interests are tied to the market value of the stock. This manipulation, however, can cause the stock price to suffer in subsequent years.
“The goal is to enable students to communicate”: Communicative competence and target varieties in TEFL practices in Sweden and Germany
Authors: Forsberg Julia , Mohr Susanne , Jansen Sandra
Published: January 2019

This paper compares teaching practices of English as a foreign language in Sweden and Germany based on a questionnaire targeted at investigating teachers’ experiences and views on language use, giving a snapshot of teaching practices in classrooms in the two countries. In this regard, the focus is on the following questions: Which target varieties are used in TEFL, and to what extent? What is the status of different target varieties among teachers of English in the two countries? The results show that the use of target varieties is still in play in the TEFL classroom, despite the recent move towards communicative competence as the goal. The main target varieties used are AmE, BrE, a mixture of the two, and some neutral variety; with a slight preference among German teachers for BrE and among Swedish for the neutral variety alongside AmE or BrE. Further, teachers are in conflict between two ideals: learned (where they teach an English belonging to the native speakers) and didactic (where the goal is communicative fluency). In application, this conflict should be addressed by teacher training programmes in order to make (future) teachers aware of it and provide possible ways to cope with it.