bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Synthesis and Biological Evaluation: 5-amino-1H-pyrazole-1- carbonyl derivatives as FGFR Inhibitors
Authors: Zhang Yan , Yu Niefang
Published: June 2020

Background:

Fibroblast growth factors (FGFs) and their high affinity receptors (FGFRs)
play a major role in cell proliferation, differentiation, migration, and apoptosis. Aberrant FGFR signaling
pathway might accelerate development in a broad panel of malignant solid tumors. However,
the full application of most existing small molecule FGFR inhibitors has become a challenge due to
the potential target mutation. Hence, it has attracted a great deal of attention from both academic and
industrial fields for hunting for novel FGFR inhibitors with potent inhibitory activities and high selectivity.

Objective:

Novel 5-amino-1H-pyrazole-1-carbonyl derivatives were designed, synthesized, and
evaluated as FGFR inhibitors.

Methods:

A series of 5-amino-1H-pyrazole-1-carbonyl derivatives were established by a condensation
of the suitable formyl acetonitrile derivatives with either hydrazine or hydrazide derivatives in
the presence of anhydrous ethanol or toluene. The inhibitory activities of the target compounds were
screened against the FGFRs and two representative cancer cell lines. Tests were carried out to observe
the inhibition of 8e against FGFR phosphorylation and downstream signal phosphorylation in
human gastric cancer cell lines (SNU-16). The molecular docking of all the compounds were performed
using Molecular Operating Environment in order to evaluate their binding abilities with the
corresponding protein kinase.

Results:

A series of 5-amino-1H-pyrazole-1-carbonyl derivatives have been designed and synthesized,
screened for their inhibitory activities against FGFRs and cancer cell lines. Most of the target
compounds showed moderate to good anti-proliferate activities against the tested enzymes and cell
lines. The most promising compounds 8e suppressed FGFR1-3 with IC50 values of 56.4, 35.2, 95.5 nM,
and potently inhibited the SNU-16 and MCF-7 cancer cells with IC50 values of 0.71 1.26 μM, respectively.
And 8e inhibited the growth of cancer cells containing FGFR activated by multiple mechanisms. In
addition, the binding interactions were quite similar in the molecular models between generated
compounds and Debio-1347 with the FGFR1.

Conclusion:

According to the experimental findings, 5-amino-1H-pyrazole-1-carbonyl might serve
as a promising template of an FGFR inhibitor.
Identification of Key mRNAs, miRNAs, and mRNA-miRNA Network Involved in Papillary Thyroid Carcinoma
Authors: Han Wei , Lu Dongchen , Wang Chonggao , Cui Mengdi , Lu Kai
Published: June 2020

Background:

In the past decades, the incidence of thyroid cancer (TC) has been gradually increasing, owing to
the widespread use of ultrasound scanning devices. However, the key mRNAs, miRNAs, and mRNA-miRNA network in
papillary thyroid carcinoma (PTC) has not been fully understood.

Material and Methods:

In this study, multiple bioinformatics methods were employed, including differential expression
analysis, gene set enrichment analysis, and miRNA-mRNA interaction network construction.

Results:

First, we investigated the key miRNAs that regulated significantly more differentially expressed genes based on
GSEA method. Second, we searched for the key miRNAs based on the mRNA-miRNA interaction subnetwork involved
in PTC. We identified hsa-mir-1275, hsa-mir-1291, hsa-mir-206 and hsa-mir-375 as the key miRNAs involved in PTC
pathogenesis.

Conclusion:

The integrated analysis of the gene and miRNA expression data not only identified key mRNAs, miRNAs,
and mRNA-miRNA network involved in papillary thyroid carcinoma, but also improved our understanding of the
pathogenesis of PTC.
The Quality of Building as a Whole for Public Preschools at Klang Valley in Malaysia
Authors: Shaari Mariam Felani , Sheikh Ahmad Sabarinah , Ismail Izaham Shah
Published: June 2020

High-quality preschool buildings are crucial for pedagogy. This paper explores and proposes improvements to the ‘building as a whole’ quality of 26 Malaysian public preschools in Klang Valley. Five aspects (image and scale, circulation, common core of shared facilities, indoor environmental quality, safety, and security) were assessed with the Children’s Physical Environment Rating Scale. The average ‘building as a whole’ quality is rated ‘Good’ and none were rated ‘Excellent’ nor ‘Poor’. However, the ‘common core of shared facilities’ aspect was only rated ‘Fair’ in most preschools. Recommendations are hoped to guide stakeholders to ensure better preschools in Malaysia.Keywords: circulation; facilities; image and scale; indoor environmental quality; safety and security.eISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5iSI1.2291
Chemical Weed Management in SRI and Transplanted Rice under Temperate Condition
Authors: Pandey LAL SINGH , SINGH PARMEET , KANTH R H , SAAD A A , BHAT M A , PIR F A
Published: June 2020

Field experiment was conducted at Research Form of Faculty of Agriculture, SKUAST-Kashmir, Wadura, in a two factor randomized block design with three replications during kharif 2017 and 2018, to evaluate weed management in rice under SRI and normal Transplanting conditions. Application of butachlor @ 1.5 kg ai/ha as pre emergence fb oxadiargyl @ 100 g ai / ha as post emergence fallowed by application of bensulfuron methyl 0.6 % + pretilachlor 6 % GR (Erage) @ 10 kg/ha as pre emergence recorded significantly greater grain, straw and biological yield than all other weed management practices and weedy check. Grain yield increased by about 29% with application of Butachlor 1.5 kg a.i.ha-1 as pre emergence fb Oxadiargyl 100 g a.i.ha-1 as post emergence over butachlor application alone. Both the planting methods were counted statistically similar number of weeds / m2 and recorded higher weed biomass and weed control efficiency at all the growth stages during both the years. The data reviled that significant increase in grain yield, number of panicles/m2 and grains / panicle in system of rice intensification (SRI) over normal transplanting method, however straw yield, biological yield and test weight did not differ significantly during both the years.
Designe and Development and Evaluation of Pepper Harvester
Authors: STANLY NISHANTH M , R JAYAN P , MALKANI PANKAJ , WANKHADE RATNAKIRAN D
Published: June 2020

Kerala is the leading producer of Black Pepper, king of spices in India. The harvesting of pepper is of great concern to the farmers. The shortage of labour during harvesting and their high wages causes a burden to pepper farmers. The delay in harvest reduces quality. The machine developed was expected to bridge the gap between supply and demand of pepper. The machine consists of a motor, mainframe, harvesting and conveying unit and collecting bag. Initial testing of the developed model was conducted under field condition. The tests revealed that the developed model was successful and effective for harvesting pepper due to its better conveying mechanism towards the collecting bag. With few modifications, the harvester could be made available for commercial production.
Effectiveness of a 3-Month Mobile Phone–Based Behavior Change Program on Active Transportation and Physical Activity in Adults: Randomized Controlled Trial (Preprint)
Authors: Ek Anna , Alexandrou Christina , Söderström Emmie , Bergman Patrick , Delisle Nyström Christine , Direito Artur , Eriksson Ulf , Henriksson Pontus , Maddison Ralph , Trolle Lagerros Ylva , Bendtsen Marcus , Löf Marie
Published: June 2020

BACKGROUND

Active transportation (AT; ie, walking and cycling as a mode for transportation) has been associated with decreased morbidity and mortality; however, low-cost and scalable intervention programs are lacking.

OBJECTIVE

The goal of the research was to determine the effectiveness of a 3-month behavior change program delivered via a mobile phone app to promote AT (TravelVu Plus) on time spent in moderate-to-vigorous physical activity (MVPA).

METHODS

For this 2-arm parallel randomized controlled trial, we recruited a population-based sample of 254 adults from Stockholm County who were aged 20 to 65 years and had access to a smartphone. On completion of 1-week baseline measures, the 254 participants were randomized to either the control or intervention group (1:1 ratio). Both groups had access to the standard TravelVu app (Trivector AB) for monitoring their AT for 6 months. The intervention group also received a 3-month behavior change program to promote AT (TravelVu Plus app). Assessors of outcomes were blinded to group allocation. Outcomes were objectively measured MVPA at 3 (primary) and 6 months. Secondary outcomes were AT, attitudes toward AT, and health-related quality of life at 3 and 6 months.

RESULTS

No effect on MVPA was observed after 3 months (P=.29); however, at 6 months the intervention group had a greater improvement in MVPA than the controls (6.05 minutes per day [95% CI 0.36 to 11.74; P=.04]). A Bayesian analyses showed that there was a 98% probability that the intervention had any effect at 6 months, and a 63% probability that this effect was >5 minute MVPA per day.

CONCLUSIONS

No effect on MVPA immediately after the intervention period (at 3 months) was observed; however, there was a delayed effect on MVPA (6 minutes per day) at 6 months, which corresponds to approximately 30% of the weekly MVPA recommendation. Our findings suggest that a behavior change program promoting AT delivered via an app may have a relevant effect on PA.

CLINICALTRIAL

ClinicalTrials.gov NCT03086837; https://clinicaltrials.gov/ct2/show/NCT03086837

INTERNATIONAL REGISTERED REPORT

RR2-10.1186/s12889-018-5658-4
Women’s Adoption of a Web-Based Intervention for Stress Urinary Incontinence: a Qualitative Study (Preprint)
Authors: Firet Lotte , Teunissen Theodora Alberta Maria , Kool Rudolf Bertijn , van Doorn Lukas , Aourag Manal , Lagro-Janssen Antoinette Leonarda Maria , Assendelft Willem Jan Jozef
Published: June 2020

BACKGROUND

Stress urinary incontinence (SUI) is common among women and affects their quality of life. Pelvic floor muscle training is an effective conservative therapy, but only a minority of women seek help. E-health with pelvic floor muscle training is effective and increases access to care. To implement an e-Health intervention in a sustainable way, however, we need to understand what barriers and facilitators determine adoption.

OBJECTIVE

to investigate the barriers and facilitators to adopting an e-Health intervention among Dutch women with stress urinary incontinence.

METHODS

semi-structured telephonic interviews were carried out among participants of the Dutch e-Health intervention for women with stress urinary incontinence. Women were purposively sampled. The ‘Fit between Individuals, Task and Technology’ (FITT) framework was used for both the data collection and data analysis, to gain a more in-depth insight into the adoption of the intervention.

RESULTS

twenty women were interviewed, mean age 51 years. The adoption of e-Health for women with SUI mainly depends on the interaction between users and e-Health, and users and pelvic floor muscle training exercises. Facilitators for the adoption were the preference for an accessible self-management intervention, having a strong sense of self-discipline and having the ability to schedule the exercises routinely. Women needed to possess self-efficacy to do this intervention independently. Barriers to the adoption of e-Health were personal circumstances restricting time for scheduling pelvic floor muscle training and lacking skills to perform the exercises correctly. Despite guidance by technical features, such as a stepwise set-up or automated e-mail reminders, several women remained uncertain about their performance of the exercises and, therefore, wanted additional contact with a professional.

CONCLUSIONS

We showed that for stress urinary incontinence, which is often not presented in medical care, e-Health is an appropriate option for a target audience. Use of the FITT framework clearly demonstrates the conditions for optimal adoption. For participants it was a suitable alternative for medical care in person. For others it identified the need for further support by a health care professional. This support could be provided by improvements of technical features and incorporating modes for digital communication. The additional value of integration of the e-Health intervention in primary care might be a logical next step.

CLINICALTRIAL

Netherlands Trial Registry (NTR) NTR6956; https://www.trialregister.nl/trial/6570.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/13164
The Study of Care Need Assessment with Comprehesive Assessment Tool for Long Term Care in China: Taking the Use of CARE in ShangHai as an Example (Preprint)
Authors: Cui Yan-Yan , Liu Yang , Liu Ping , Zou Min , Jiang Li-Ping , Chang Polun
Published: June 2020

BACKGROUND

Comprehensively evaluating the care needs of older adults is the premise for implementing integrated care. Nonetheless, the system as a pilot project is still at the observation stage in several cities. Shanghai was the first city to launch a medical and long-term care integrated comprehensive assessment, and at this stage, validating whether the current care needs assessment scale effectively identifies older people’s care needs is vital.

OBJECTIVE

The objectives of this study is to design and establish a mobile care platform(mCARE+) integrating assessment implementation, care issue identification, and care planning comprehensive assessment instrument, then use the technology acceptance model for mobile services (TAMM) questionnaire to investigate care-providing staff’s technology acceptance of mCARE+.

METHODS

First, the expert assessment approach was adopted to combine the CARE and UCNAS to form a new comprehensive assessment instrument, CARE+. Second, the Resident Assessment Instrument (RAI) 3.0 was decomposed to determine the logic for generation of care issues, which could be used to form care issues triggered by CARE+. Third, the 3 + 1 hierarchical matrix interface design principle was employed to establish CARE+ and care procedures on the mobile care platform, forming mCARE+, an application platform linking assessment to care issue identification. Fourth, convenience sampling was adopted to select 18 nursing employees from a hospital and its affiliated nursing home in Shanghai for technology acceptance evaluation of mCARE+ utility, ease of use, reliability, acceptance, and satisfaction.

RESULTS

and the total level of satisfaction reached 100%. Their levels of satisfaction for its ease of use and usefulness were both greater than 90%; however, approximately one-third of the participants were concerned about data security.

CONCLUSIONS

The present study demonstrated that the intended applications of a comprehensive assessment can be achieved by using technology effectively. Several critical care issues were overlooked when using the unified care needs assessment scale, which is currently used in Shanghai. Whether the results of the assessment can be directly applied to ascertain a suitable care facility for an older person and plan the corresponding care measures requires further investigation. These overlooked critical care issues may affect health care outcomes and care resource usage; therefore, these issues should be considered when deciding on the care level and expenditure.
Smart Healthcare Interventions for Smoking Cessation: A Scoping Review (Preprint)
Authors: Liou Yen Ju , Lee Chun Ying , Lee Chiou-Mei , Wu Cheng Hang
Published: June 2020

BACKGROUND

Smart healthcare devices are being increasingly employed to support medical services, and evidence has shown promising results in using such tools for smoking cessation, but there has been no scoping review on this topic so far and the trends of research in this area has not been fully examined. This review provides a comprehensive evaluation of research in this area.

OBJECTIVE

This scoping review aimed to analyze the research trends in this area to speculate on the future of smart health devices for smoking cessation.

METHODS

The study was based on the methodology of scoping review. Literature searches were done in PubMed, EMBASE, MEDLINE using terms related to smart healthcare. Titles, abstracts, and full reports were reviewed independently by two reviewers. Papers were included if they focused on discussing smart healthcare interventions for smoking cessation. Data were extracted independently by two reviewers.

RESULTS

Searches identified 3982 references and 25 papers were included in the scoping review. Mobile applications was the most numerous category of studies, making up 56% (n=14) of all studies and this had increased markedly in recent 5 years. We identified 6 types of outcome measures. Besides quit rate, user attitude was the most frequently measured outcome, accounting for 44% (n=11) of the studies. Nine studies targeted special populations other than general adult smokers, nearly half (n=4) of which targeted adolescents or young adults.

CONCLUSIONS

Besides quit rate, the researchers put most focus on user attitude. Use of mobile applications seem to be the mainstream in the future among smart healthcare interventions for smoking cessation. Future research including more keywords related to smart healthcare interventions is needed for a comprehensive understanding of this field.
Automated Computer Vision Assessment of Hypomimia in Parkinson Disease: Proof-of-Principle Pilot Study (Preprint)
Authors: Abrami Avner , Gunzler Steven , Kilbane Camilla , Ostrand Rachel , Ho Bryan , Cecchi Guillermo
Published: June 2020

BACKGROUND

Facial expressions require the complex coordination of 43 different facial muscles. Parkinson disease (PD) affects facial musculature leading to “hypomimia” or “masked facies.”

OBJECTIVE

We aimed to determine whether modern computer vision techniques can be applied to detect masked facies and quantify drug states in PD.

METHODS

We trained a convolutional neural network on images extracted from videos of 107 self-identified people with PD, along with 1595 videos of controls, in order to detect PD hypomimia cues. This trained model was applied to clinical interviews of 35 PD patients in their on and off drug motor states, and seven journalist interviews of the actor Alan Alda obtained before and after he was diagnosed with PD.

RESULTS

The algorithm achieved a test set area under the receiver operating characteristic curve of 0.71 on 54 subjects to detect PD hypomimia, compared to a value of 0.75 for trained neurologists using the United Parkinson Disease Rating Scale-III Facial Expression score. Additionally, the model accuracy to classify the on and off drug states in the clinical samples was 63% (22/35), in contrast to an accuracy of 46% (16/35) when using clinical rater scores. Finally, each of Alan Alda’s seven interviews were successfully classified as occurring before (versus after) his diagnosis, with 100% accuracy (7/7).

CONCLUSIONS

This proof-of-principle pilot study demonstrated that computer vision holds promise as a valuable tool for PD hypomimia and for monitoring a patient’s motor state in an objective and noninvasive way, particularly given the increasing importance of telemedicine.
A Medical Translation Assistant for Non–English-Speaking Caregivers of Children With Special Health Care Needs: Proposal for a Scalable and Interoperable Mobile App (Preprint)
Authors: Sezgin Emre , Noritz Garey , Hoffman Jeffrey , Huang Yungui
Published: June 2020

BACKGROUND

Communication and comprehension of medical information are known barriers in health communication and equity, especially for non–English-speaking caregivers of children with special health care needs.

OBJECTIVE

The objective of this proposal was to develop an interoperable and scalable medical translation app for non–English-speaking caregivers to facilitate the conversation between provider and caregiver/patient.

METHODS

We employed user-centered and participatory design methods to understand the problems and develop a solution by engaging the stakeholder team (including caregivers, physicians, researchers, clinical informaticists, nurses, developers, nutritionists, pharmacists, and interpreters) and non–English-speaking caregiver participants.

RESULTS

Considering the lack of interpreter service accessibility and advancement in translation technology, our team will develop and test an integrated, multimodal (voice-interactive and text-based) patient portal communication and translation app to enable non–English-speaking caregivers to communicate with providers using their preferred languages. For this initial prototype, we will focus on the Spanish language and Spanish-speaking families to test technical feasibility and evaluate usability.

CONCLUSIONS

Our proposal brings a unique perspective to medical translation and communication between caregiver and provider by (1) enabling voice entry and transcription in health care communications, (2) integrating with patient portals to facilitate caregiver and provider communications, and (3) adopting a translation verification model to improve accuracy of artificial intelligence–facilitated translations. Expected outcomes include improved health communications, literacy, and health equity. In addition, data points will be collected to improve autotranslation services in medical communications. We believe our proposed solution is affordable, interoperable, and scalable for health systems.
Perception of COVID-19 Physical Distancing Effectiveness and Contagiousness of Asymptomatic Individuals: Cross-sectional Survey of Deaf and Hard of Hearing Adults in the United States (Preprint)
Authors: Paludneviciene Raylene , Knight Tracy , Firl Gideon , Luttrell Kaela , Takayama Kota , Kushalnagar Poorna
Published: June 2020

BACKGROUND

During the COVID-19 pandemic, there has been a rapid increase in the amount of information about the disease and SARS-CoV-2 on the internet. If the language used in video messages is not clear or understandable to deaf and hard of hearing (DHH) people with a high school degree or less, this can cause confusion and result in information gaps among DHH people during a health emergency.

OBJECTIVE

The aim of this study is to investigate the relationship between DHH people's perception of the effectiveness of physical distancing and contagiousness of an asymptomatic person.

METHODS

This is a cross-sectional survey study on DHH people's perceptions about COVID-19 (N=475). Items pertaining to COVID-19 knowledge were administered to US deaf adults from April 17, 2020, to May 1, 2020, via a bilingual American Sign Language/English online survey platform.

RESULTS

The sample consisted of 475 DHH adults aged 18-88 years old, with 74% (n=352) identifying as White and 54% (n=256) as female. About 88% (n=418) of the sample felt they knew most things or a lot about physical distancing. This figure dropped to 72% (n=342) for the question about the effectiveness of physical distancing in reducing the spread of COVID-19 and 70% (n=333) for the question about the contagiousness of an infected person without symptoms. Education and a knowledge of the effectiveness of physical distancing significantly predicted knowledge about the contagiousness of an asymptomatic individual. Race, gender, and age did not emerge as significant predictors.

CONCLUSIONS

This results of this study point to the strong connection between education and coronavirus-related knowledge. Education-related disparities can be remedied by making information fully accessible and easily understood during emergencies and pandemics.
Life after Lockdown due to COVID-19: An Indian Perspective (Preprint)
Authors: KASSA SANKIT , ADKI KAVERI
Published: June 2020

BACKGROUND

Lockdown has been imposed on 24 March 2020 by Government of India under the leadership of Prime Minister Mr. Narendra Modi continuously for 68 days in different 4 phases. On 30 May 2020, Unlock-1 phase is started with some limitations. One can easily reckon form all of this that we all will have to coexist with the virus for the coming months until we get the vaccine or we get proper immunity to fight against it.

OBJECTIVE

COVID-19 pandemic has altered our daily routines and lifestyles. People in India wants to go back to their pre-Covid days and are eagerly looking for living a normal life once the lockdown is lifted. Main objective of this paper is to predict the life style of people after lockdown, considering different parameters and sectors of society.

METHODS

Different survey papers as well as articles have been reviewed for going through the subject matter of life style after lockdown. Consultation with relatives and friends has been done, through various online medium and phone calls, for sharing their experience of lockdown period and knowing their perception about future and expectations after post-lockdown

RESULTS

Various category people will have different novel types of issues either at work places or at businesses, which requires unique and out-of-the-box solutions. All the various possible aspects of living life in future have been discussed in the manuscript step by step

CONCLUSIONS

The norms of social etiquette that define our daily lives will change in the post-lockdown world as people emerge into a wary new world. This manuscript gives a brief look for a basic and crucial question, which every Indian citizen may be asking: how life would be post lockdown?
Rapid Changes in Telehealth Access among Vulnerable Populations Amid Covid-19 Policy Expansions: Cross-sectional Study (Preprint)
Authors: Khairat Saif , Yao Yuxiao , Coleman Cameron , Shea Christopher , Edson Barbara , Gianforcaro Robert
Published: June 2020

UNSTRUCTURED

Objective
To examine the effect of the Covid-19 policy expansions on telehealth access among vulnerable populations including uninsured, seniors, and rural patients.
Data Sources
Primary data collection of telehealth visits between January 21- April 19, 2020.
Data Collection
Study data was collected through the online platform and extracted from the institutional data warehouse for processing and analysis.
Study Design
We conducted a cross-sectional analysis of virtual visits through a state-wide telehealth center embedded in a large academic healthcare system. Primary outcomes of this study were changes in health access among vulnerable populations and changes in provider staffing to stabilize the telehealth practice.
Principal Findings
A total of 2132 telehealth visits were conducted, 1530(71.8%) patients were female, 1561(73.2%) were between the ages 18-50, 1576(74%) were uninsured, and 1225(57.5%) were from rural regions. A significant increase in access among senior (p<0.05), uninsured (p<0.001), and rural (p=0.001) patients, and video visits (p<0.001) occurred in response to the telehealth expansion.
Post-expansion, the daily average number of telehealth visits and wait times increased by 229% and 436% respectively, which required an increase in telehealth providers by 228% to meet patient demands. The predictive model expected 394% increase in virtual visits through June, 2020 (95% CI: 2892-8579).
Conclusions
Recent telehealth policy expansions appear to expand access to vulnerable populations such as senior, uninsured, and rural patients while decompressing hospitals and emergency rooms and maintaining positive patient experiences. While the policy expansion displayed effectiveness, additional measures are needed. These include the need for regulations around virtual visits unintended consequences, certification of telehealth software, and guidelines for workforce training.
Young People’s Attitude Toward Positive Psychology Interventions: Thematic Analysis (Preprint)
Authors: Michel Toni , Tachtler Franziska , Slovak Petr , Fitzpatrick Geraldine
Published: June 2020

BACKGROUND

Digital instantiations of positive psychology intervention (PPI) principles have been proposed to combat the current global youth mental health crisis; however, young people are largely not engaging with available resources.

OBJECTIVE

The aim of this study is to explore young people’s attitudes toward various PPI principles to find ways of making digital instantiations of them more engaging.

METHODS

We conducted an explorative workshop with 30 young people (aged 16-21 years). They rated and reviewed 29 common PPIs. Ratings and recorded discussions were analyzed using thematic analysis.

RESULTS

Some interventions were conflicting with young people’s values or perceived as too difficult. Participants responded positively to interventions that fit them personally and allowed them to use their strengths.

CONCLUSIONS

Values, context, strengths, and other personal factors are entangled with young people’s attitudes toward digital instantiations of PPI principles.
COVIDApp as an Innovative Strategy for the Management and Follow-Up of COVID-19 Cases in Long-Term Care Facilities in Catalonia: Implementation Study (Preprint)
Authors: Echeverría Patricia , Mas Bergas Miquel Angel , Puig Jordi , Isnard Mar , Massot Mireia , Vedia Cristina , Peiró Ricardo , Ordorica Yolanda , Pablo Sara , Ulldemolins María , Iruela Mercé , Balart Dolors , Ruiz José María , Herms Jordi , Clotet Sala Bonaventura , Negredo Eugenia
Published: June 2020

BACKGROUND

The coronavirus disease (COVID-19) pandemic has caused an unprecedented worldwide public health crisis that requires new management approaches. COVIDApp is a mobile app that was adapted for the management of institutionalized individuals in long-term care facilities.

OBJECTIVE

The aim of this paper is to report the implementation of this innovative tool for the management of long-term care facility residents as a high-risk population, specifically for early identification and self-isolation of suspected cases, remote monitoring of mild cases, and real-time monitoring of the progression of the infection.

METHODS

COVIDApp was implemented in 196 care centers in collaboration with 64 primary care teams. The following parameters of COVID-19 were reported daily: signs/symptoms; diagnosis by reverse transcriptase–polymerase chain reaction; absence of symptoms for ≥14 days; total deaths; and number of health care workers isolated with suspected COVID-19. The number of at-risk centers was also described.

RESULTS

Data were recorded from 10,347 institutionalized individuals and up to 4000 health care workers between April 1 and 30, 2020. A rapid increase in suspected cases was seen until day 6 but decreased during the last two weeks (from 1084 to 282 cases). The number of confirmed cases increased from 419 (day 6) to 1293 (day 22) and remained stable during the last week. Of the 10,347 institutionalized individuals, 5,090 (49,2%) remained asymptomatic for ≥14 days. A total of 854/10,347 deaths (8.3%) were reported; 383 of these deaths (44.8%) were suspected/confirmed cases. The number of isolated health care workers remained high over the 30 days, while the number of suspected cases decreased during the last 2 weeks. The number of high-risk long-term care facilities decreased from 19/196 (9.5%) to 3/196 (1.5%).

CONCLUSIONS

COVIDApp can help clinicians rapidly detect and remotely monitor suspected and confirmed cases of COVID-19 among institutionalized individuals, thus limiting the risk of spreading the virus. The platform shows the progression of infection in real time and can aid in designing new monitoring strategies.
Impact of the COVID-19 Epidemic on Lifestyle Behaviors and Their Association With Subjective Well-Being Among the General Population in Mainland China: Cross-Sectional Study (Preprint)
Authors: Hu Zhao , Lin Xuhui , Chiwanda Kaminga Atipatsa , Xu Huilan
Published: June 2020

BACKGROUND

The world is experiencing an unprecedented challenge due to the coronavirus disease (COVID-19) pandemic. However, it is unclear whether people’s lifestyles will change as a result.

OBJECTIVE

The aim of this study is to explore perceived lifestyle changes after the outbreak of COVID-19 and their association with subjective well-being (SWB) among the general population in Mainland China.

METHODS

An online survey was conducted in May 2020. Lifestyle behaviors including leisure-time physical exercise, leisure-time screen time, and dietary intake were self-reported. SWB was measured using the General Wellbeing Schedule (GWS). Other covariates including sociodemographic factors, self-rated physical health, perceived social support, and loneliness were also assessed by a structured questionnaire. A multivariate ordinal regression method was used to analyze the association between SWB and lifestyle behaviors as well as perceived lifestyle changes.

RESULTS

A total of 1033 participants aged between 18 and 60 years were included in this study. The mean GWS score was 71.7 points. About 70% of the respondents reported spending more time looking at screens, whereas about 30% reported an increased frequency of vegetable and fruit intake after the outbreak of COVID-19. Inactive physical exercise (odds ratio [OR] 1.16, 95% CI 1.02-1.48), infrequent vegetable intake (OR 1.45, 95% CI 1.10-1.90), infrequent fruit intake (OR 1.31, 95% CI 1.01-1.70), and often skipping breakfast (OR 1.43, 95% CI 1.08-1.91) were associated with lower SWB after adjusting for sociodemographic factors, self-rated physical health, perceived social support, and loneliness. Moreover, participants who perceived a decrease in the frequency of vegetable, fruit, and breakfast intake were more likely to report lower SWB.

CONCLUSIONS

The COVID-19 pandemic may have positive and negative impacts on different aspects of lifestyle behaviors. Both unhealthy lifestyle behaviors and negative lifestyle changes were associated with lower SWB. These findings provide scientific evidence that can inform lifestyle guidelines and public mental health interventions during the COVID-19 outbreak.
Alternative Proteins: Market Research on Consumer Trends and Emerging Landscape
Authors: Joseph Poulson , Searing Audrey , Watson Chloe , McKeague Jill
Published: June 2020

Meat and poultry consumption is set for global growth with increased demand. However, today’s market trends demonstrate that new consumers are interested in alternative proteins (i.e., non–animal-derived/plant proteins). In the past few years, this interest has been growing and has resulted in the revamp of “alternative protein” segments and new product launches that can compete with or complement traditional meat products. The market trends also strongly support a continued demand for meat and poultry consumption as the alternative protein segment possesses less than 4% of the total global protein share. At the same time, the accelerated growth (with Compound Annual Growth Rate 2–3 times greater than that for meat and poultry, globally) and market penetration of alternative proteins, coupled with consumer interests fueled by the “flexitarians,” present an opportunity to review the current situation, global trends, and consumer research and to evaluate the potential and gaps for the meat and poultry industry. Furthermore, the technological aspects of utilizing alternative proteins (non–animal-derived) also presents an opportunity to create new experiences for a customer familiar with meat/meat product consumption. The present International Congress of Meat Science and Technology proceedings paper, therefore, offers a short glance into the market landscape of alternative proteins, as we stride to a common goal of feeding 2 billion more people by 2050.
México hoy
Authors: Cabrera Morales Sergio
Published: June 2020

Reseña al libro Neoliberalismo. Utopías y financiamiento en México, Coordinadoras: Eugenia Correa y Alicia Girón, UNAM, 2020.

El  contenido de la presente compilación se destacan las  características: el horizonte temático que abarca es variado y se aborda desde varias perspectivas  teóricas y metodológicas; así como desde  la perspectiva del sector externo, la economía nacional en varios ámbitos.
La “universidad participativa”: ¿una alternativa al “Modo 2"?
Authors: Rubião-Resende André , Zilberberg-Oviedo Lourdes-Evangelina
Published: June 2020

Este artículo presenta una reflexión sobre la universidad contemporánea y ofrece una crítica al modelo hegemónico, llamado “Modo 2”, que propone la contextualización de la universidad, orientada por un paradigma económico. Se presentan dos propuestas alternativas: una denominada “autonomista”, cuyos orígenes se remontan al “modelo humboldtiano” y otra que se titula “participativa”, que surgió a partir del “movimiento de Córdoba”. El presente artículo defiende el modelo “participativo”, que al contrario del “autonomista”, es capaz de aprovechar el cuadro analítico del “Modo 2”, sin caer en la trampa neoliberal.
Penerapan Aplikasi 1001 Majas guna mempermudah pemahaman majas siswa SMA di Kota Malang
Authors: Sumantri Dini Anggita , Anggraini Wulan Ria , Anggraini Purwati
Published: June 2020

Majas dalam pembelajaran bahasa Indonesia merupakan sebuah objek kajian yang menarik untuk diteliti. Hal ini disebabkan karena kurangnya pengetahuan siswa mengenai majas, sehingga memerlukan sebuah aplikasi yang dapat membantu dan memudahkan siswa dalam belajar majas. Penelitian ini bertujuan mendeskripsikan penerapan Aplikasi 1001 Majas guna membantu dan mempermudah pemahaman mengenai majas pada siswa SMA di Kota Malang. Penelitian ini menggunakan metode persentase deskriptif. Responden dalam penelitian ini adalah siswa kelas X SMAN 7 Malang dan MA Al-Irtiqo’ sebagai populasi penelitian. Total terdapat 5 kelas di SMAN 7 Malang dan 2 kelas di MA Al-Irtiqo’, berdasarkan kondisi tersebut maka digunakan teknik simple random sampling untuk menentukan sampel penelitian, sehingga didapatkan siswa kelas X1 dan X3 di SMAN 7 Malang serta Kelas X1 dan X2 di  MA Al-Irtiqo’ sebagai sampel penelitian. Teknik pengumpulan data menggunakan wawancara dan kuesioner. Teknik analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa (1) penerapan Aplikasi 1001 Majas mampu memudahkan pemahaman mengenai majas dalam pembelajaran bahasa Indonesia dan (2) keberadaan Aplikasi 1001 Majas juga dapat berperan sebagai media pembelajaran yang dapat memberikan manfaat yang berguna pada siswa.
Biodata Penulis
Authors: Kusumaningrum Demeiati Nur
Published: June 2020

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Tinjauan Implementasi Pembangunan Berkelanjutan: Pengelolaan Sampah Kota Kendari
Authors: Sudirman Faturachman Alputra , Phradiansah Phradiansah
Published: June 2020

Waste management issues is the primary concern of the Kendari City Government, considering to become a liveable city namely the sustainable development of Kendari City. This study discusses the challenges of implementing a waste management policy based sustainable development in Kendari City. One of the goals of sustainable development on the 2030 agenda is to reduce the impact of the urban environment with the percentage of municipal reliable waste handling indicators. The purpose of this study is to determine the implementation of waste management policies using the concept of policy implementation by Edwards III and to link it to the concept of sustainable development and the 2030 agenda of Sustainable Development Goals (SDGs). This study used a qualitative method, in which data was collected through interviews and documentation, the findings in this study that the implementation of waste management policies in Kendari City was quite excellent in the aspects of communication, resources, disposition, and bureaucratic structure. However, various challenges were also present in every aspect of policy implementation. Overall, the implementation of waste management policies also takes into account sustainable development in economic, social and environmental aspects and was by efforts to achieve SDGs Goal 11, where 73.30 per cent of urban waste has been handled.
Book Review: Research for Social Justice
Authors: Fulton Amy E.
Published: June 2020

Research for Social Justice: A Community-Based ApproachAuthor: Adje van de Sande & Karen SchwartzPublished: 2011Published By: Fernwood Publishing, Nova Scotia, CanadaPaperback ISBN: 978-1-55266-441-4Number of Pages: 190

In recognition of the limited amount of social work research literature that is congruent with social work’s social justice values, van de Sande and Schwartz published Research for Social Justice: A Community-Based Approach. As professors at the Carleton University School of Social Work located in Ottawa, Ontario, Canada, the authors built on their classroom teaching experiences in order to develop this engaging, illustrative, and practical text. The book provides a concise guide to the structural approach to community-based research aimed toward a target audience of social work students, social work practitioners, and other learners in the social sciences disciplines.
Burnout North of 60
Authors: McKenzie Cameron
Published: June 2020

This study examined variables impacting job stress, burnout, and turnover rates among social workers north of the 60th parallel, in remote parts of Canada populated by Inuit communities. A literature review identified understaffing, social and geographic isolation, role stress, lack of professional support, and cultural and ethnic disparities as possible sources of burnout. This qualitative study evaluated these factors in relation to Northern social workers. Nine in-depth, semi-structured interviews were conducted via telephone with former Nunavut social workers, some of whom were directors, to probe the issue of burnout and turnover. Several themes emerged that are supported by the literature on burnout of social service workers in remote regions and related to the administration of Northern social work services, including understaffing, lack of supervisory support, dual role stress, and overworked staff. Findings suggest the need for giving more attention and resources to social work staff supporting Inuit clients, specifically increased staffing and culturally sensitive training.
Spiritual Wounding and Affliction
Authors: Kruk Edward
Published: June 2020

This paper explores the writings of metaphysical philosopher and social activist Simone Weil on spiritual wounding and affliction, as well as implications for the development of a spiritually-grounded and -sensitive social work practice. The nature of spiritual affliction is considered, challenges to discerning spiritual trauma discussed, and barriers to receiving help for those in the midst of such wounding revealed. A framework for social work practice based on a spiritual foundation is articulated, which embraces social justice as focused on human needs and social obligations, toward the goal of spiritual transformation in cases of spiritual wounding. The perspective of those experiencing spiritual affliction in the area of hard drug addiction is discussed as a case study.
Privatization
Authors: Dunlop Judith M.
Published: June 2020

Privatization of social welfare services in Canada is promoted by national, provincial, regional and municipal governments through initiatives that emphasize public-private partnerships. Together with encouraging these partnerships as a privatization strategy, government also reduces public funding and replaces it with private sector contracting for social provision. An exploratory study of the Healthy Babies/ Healthy Children (HBHC) program found an increasing acceptance of privatization by service providers in Ontario. These findings illustrate the argument that government creates the context for market-based solutions. But can market-based solutions really solve social problems, and is this the intention of government social policy?
Social Work and the anti-oppressive stance
Authors: Sinclair Raven , Albert Jason
Published: June 2020

This theoretical article addresses a concern about the anti-oppressive stance adopted by Canadian Schools of Social Work and asks the rhetorical questions to nurture the discourse: is our anti-oppressive stance, so widely adopted across the country, meaningful or is it, like the Emperor’s new clothes, illusory? Oppression, racism, and aboriginal relations in Canada are examined against a backdrop of theoretical links to imperialism and colonialism to delineate the intricacies of the problem. The article begins with an illustrative story and concludes by asking pointed questions about the willingness of social work schools, student, educators, and practitioners to turn to the task of translating the theoretical of anti-oppression in the practical.
The Eco-Mesh Approach: A Sustainable Methodology for Socio-Culturally Interrogative Artistic Research
Authors: Charulatha Mani
Published: June 2020

One of the most striking features of Artistic Research is that apparently disjointed issues including pressing calls to action from social, ethical, political and cultural perspectives can organically unfold, evolve, and shape interdisciplinary academic discourses through the centralised lens of artmaking. It thereby creates a holistic picture of research in a manner that only an artist’s singular perspective can yield. A methodology approach that looks from the enmeshed and messy microcosms of ecologies at interplay to the broader macrocosms of the world, through the lenses of socio-cultural interrogation and ethical accountability, I argue, presents an sustainable model for a decolonised artistic research ethos to emerge. According in this publication, I offer "an ecomesh approach" to achieving a framework for "socio-culturally interrogative artistic research" with music and culture as my two key modes of inquiry. As a female native culture bearer of South Indian Classical music now also active within the sphere of Western academia, I feel that I have an ethical responsibility towards the ways in which culturally contingent aspects of my music and culture are represented in and communicated to the world (both in education and artmaking). I leverage my insider/outsider position to problematise aspects of power, belonging, and ownership in global ecologies of dissemination and reception of material and material labour.
from foaming exercises to scenarios of co-existencies – anticipating emancipatory practices of space
Authors: Maiju Loukola
Published: June 2020

The structure and dynamics of worldly spaces are neighbourhoodly. In them, different kinds of life forms are connected, in a sharing relation, whether they like it or not. The other facet of the same coin is co-isolation and a state of shared closure. Any position from loving and intimate to aggressive or forced, from solidarity to imprisonment, is detached to and depicted through spatial relations. Infected by the “interpretation of foams” in the final volume of Peter Sloterdijk’s Spheres trilogy, I chose to take foam architecture onto a surgical table and take a closer look at its spatial, material, metaphorical and conceptual implications. I became driven in making inquieries on co-joined spatiality characterized by the “ontological nervousness of the co-existent, the other, the outer”.[1]

The Foaming Exercises installation was part of one of the research cells of the Research Pavilion #3 and became the first part of an (ongoing) examination of spatial co-existencies. Since then, the study has evolved into an ongoing further study on co-joined spatialities in relation to the emancipatory potential of spatial practices in urban context.