bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Decolonising Framework for Aboriginal and Torres Strait Islander Health Policy Analysis in Australia
Authors: Kehoe Helen , Schütze Heike , Spurling Geoffrey , Lovett Raymond
Published: March 2023

Analysis of policies relevant to Aboriginal and Torres Strait Islander Peoples could help improve health outcomes—a critical challenge in Australia. While there are many health policy analysis frameworks, we did not find one which supported decolonising approaches across stages of the policy cycle. Generic frameworks were not based on decolonising approaches, and so risk perpetuating structural inequalities underpinning health disparities. Aboriginal and Torres Strait Islander specific frameworks articulated ways of working rather than addressing policy stages. We devised a new policy analysis framework by drawing upon Aboriginal and Torres Strait Islander specific and other policy analysis frameworks. The new framework can help critically analyse existing Aboriginal and Torres Strait Islander health policy and guide future policy making.
Godność osoby ludzkiej wymiarem podmiotowości człowieka w gospodarce
Authors: Buller Leszek Jan
Published: March 2023

Poland, after social-politic-economic transformation in 1989, became a capitalistic, free-market country. In this conditions human being can be perceived as an object, not a subject of economic life. Therefore the import ant issue is to take up problems associated with human subjectivity. And human subjectivity is expressed in his personal dignity.
Dzieci rynku... Rynek dzieci... Osoby czy zasoby?
Authors: Michalski Michał A.
Published: March 2023

The status of the child in the context of contemporary socio-cultural processes that are reflected in the market is the main issue discussed in this paper. It may be surprising to concentrate on children and the market, while the sphere of economic exchange is the scene of such actions as work, production and consumption which seem to be reserved to adult members of the society. Although there are issues – such as kids advertisement and its consequences, and children’s participation in the process of buying – that are discussed, the range of problems that deserve consideration is far wider. The questions analyzed in this paper concentrate on two aspects. First of them is the influence of the market sphere on the life of children as members of the families and the society. The question that should be asked here is whether a child can and should be regarded as any other consumer, or should be protected – e.g. against controversial marketing practices. The second group of problems is connected with the objective way of treating children which leads to formation of something that can be called the markets of children”. Both these sets of issues are the stimulus to analyze the way of understanding a child and its status in the society. It is also done through taking into consideration such issues as current concepts of socialization, antipedagogy, infantilisation and adultisation that influence and shape market processes. Finally the analysis undertaken in this paper leads to an attempt to answer the question whether in the current context children are seen as persons or resources.
Idea Kodeksu Zawodowej Etyki w Rachunkowości by Accounting Association in Poland
Authors: Żuraw Paweł
Published: March 2023

Professional Ethics Code in Accounting constitutes a set of principles and values of everyday conduct of people whose work is connected with accounting. Accounting is an information system of enterprises, so it forms the basis of reliable management. Therefore information generated by accounting must be credible. Otherwise, the managing process would be based on false reports, which in consequence could lead to a fall of an economic subject, or it would at least cause the loss of clients, cooperators and associates` trust. Accounting Association in Poland as an organization with more than one hundred years` tradition for people connected with enterprise accounting out of concern for reliability and fairness of carried out and registered economic transactions, recommended the first in Poland ethics code directed to accountants as a professional group. Professional Ethics Code in Accounting is a set of norms which aim is to help people connected with accounting solve ethical dilemmas appearing in their job. It can be said that this code is, so to speak, an answer to unfair accusations formulated against accountants being (in some people`s opinion) a group of “criminals in white collars”. It is obvious that there are different people with different characters in each society. Pathologies were and will be present everywhere. Accountants` environment is not free of them, which is proved by accounting scandals in Poland and abroad (for example the case of Enron company in the United States). In order to avoid generalizing, it must be underlined that among the ones connected with accounting, there are a lot of honest people caring about the company`s good name.
Edukacja etyczna jako fundamentalny element wychowania w środowisku akademickim
Authors: Kapias Michał , Polok Ks. Grzegorz
Published: March 2023

Global changes in the world enforce to undertake various transformations also in the area of higher education. The aim of academic
education is not more preparing to work in particular occupation, but rather to form appropriate abilities which are useful at the labour
market. This kind of education must embody overall, multi-aspect character, because it prepares to lifelong learning. Therefore creating
“learning society” one should make an effort into axiological dimension of scientific-technical advance. One ought to take heed of human
elements of education and first of all of ethical issues. Practise shows that human relations bereft of transcend and ethic dimension,
but concentrating only on financial economical goods, on profit, market and competition, don’t bring anyone happiness. Hence there
is an enormous demand in the academic community an ethical reflection. Thanks to it human being is not only improved in anthropological
dimension, but also in social-economical aspect.
Konflikt interesu publicznego z prywatnym na tle instytucji wywłaszczenia nieruchomości
Authors: Stawecki Marek
Published: March 2023

Ownership, as a basic value of a legal state is the subject to special protection guaranteed by a basic law. However, in certain situations
acting for the benefit of public interest is, according to a legislator, takes priority over private ownership. Thus, in cases when public interest
is at stake limitation of ownership title to property can be permitted by regulations.
Expropriation of private property for the sake of public good is the solution used for many years in Poland and in other countries.
Basic preconditions for expropriation are described in art. 21 section 2 of The Constitution of the Republic of Poland. Private
ownership in art. 21 of Polish Constitution was defined in a very general context without defining the subject. Thus, all the ownership
is the subject to state protection without specifying the principles of this protection, which are regulated by ordinary acts. Guaranteeing right
to private ownership does not mean the right is inviolable. Constitution allows for property expropriation for the benefit of public purposes
after a just compensation. However, it must be emphasized that regulations relating to the rules of property expropriation as a special form
of depriving ownership right by means of authoritarian state act, which is the exception from general civil and legal principles of transferring
ownership title, must be applied literally, excluding admissibility of extensive interpretation.
Provisions of the constitution are defined in the regulations of the Real Estate Management Act from 21st August 1997.
Czynniki wspierające powstawanie i rozwój świadomości emerytalnej jako instrumentu pobudzania indywidualnej zapobiegliwości o przyszłość emerytalną
Authors: Klimkiewicz Aldona
Published: March 2023

Projections for replacement rate achievable from two mandatory pillars of the pension system indicate a significant reduction
in retirement income compared to regular professional activity.
The designers of the new philosophy of retirement have made an assumption that all three pillars will play equivalent role in providing
retirement income. They have also assumed that the participants of the pension system will be kept informed about the height of the expected
benefits derived from the first pillar and the amount of funds raised in the second pillar. Forecast of low (unsatisfactory) benefits
from a compulsory part of the system is supposed to persuade people to make informed decisions aimed at increasing retirement income.
Pandemic Preparedness for the Real World: Why We Must Invest in Equitable, Ethical and Effective Approaches to Help Prepare for the Next Pandemic
Authors: Wilkinson Annie , MacGregor Hayley , Scoones Ian , Schmidt-Sane Megan , Leach Melissa , Taylor Peter , Ripoll Santiago , Khan Mohmand Shandana , Abbas Syed , Hrynick Tabitha
Published: March 2023

The cost of the Covid-19 pandemic remains unknown. Lives directly lost to the disease continue to mount, while related health, livelihood and wellbeing impacts are still being felt, and the wider ramifications across society, politics and the economy are yet to fully materialise. What is known about these costs though, is that they have been unequally distributed both within and between countries. Preparedness plans proved inadequate in many settings – especially when it came to protecting those most vulnerable, including those marginalised by geography, poverty, or exclusion along the lines of religion, ethnicity or gender. The top-down, surge-style, biomedically dominated and technologically driven preparedness approach that has dominated global health thinking and which was propelled into action with Covid-19 was found wanting not only on the grounds of effectiveness, but also of social justice. This presents both a challenge and an opportunity for a convergence of the preparedness and development agendas. Drawing on a growing body of social science evidence, this report contends that securing health in the face of today’s uncertain disease threats in often unpredictable settings means making social, economic and political priorities as core to the preparedness agenda as biological and technological ones. We present here a framework for a vision of pandemic preparedness for the real world – one that accepts that context is paramount, embraces inclusivity and justice, shifts power centres and rejects simplistic, one-size-fits-all solutions.
Peningkatan Hasil Belajar dalam Pembelajaran Matematika Materi FPB & KPK melalui Media Pembelajaran Papan Musi pada Siswa Kelas IV di SDN Damarsih Sidoarjo
Authors: Ramdhania Sarah , Nisa' Shofiyun , Istiqfaroh Nurul , Syaria Siti
Published: March 2023

The study aims to develop a learning medium called the musi (multifunction) board. The learning media we choose this time is particularly suitable for implementation in both the low classes and the high classes in elementary school or elementary school. This type of research is class action research (PTK). The English term is the classroom action research (car), a research activity carried out in class. Class action research (PTK) is a study activity that involves a class action that is carried out to solve the learning problems faced by teachers, improve and produce learning and try new things in learning for the improvement and the data-collection study that is used is interviews, tests and observations. Validation obtained by 97.5% which means the musi board learning media can be applied. Based on data already obtained, it could be concluded that knowledge or cognition of the ivs-ds class damarsi increased with the application of the musi (multi-function) learning media so that the action carried out in the study was said to be successful without further action.
Framing smart working in the Covid-19 era: a data driven approach
Authors: Piscopo Gabriella , Loia Francesca , Adinolfi Paola
Published: March 2023

In the last years, smart working has been introduced as an agile and dynamic way of working which provides high levels of performance, productivity, and job satisfaction in a “triple-win” configuration for customers, employees, and organizations. Although the advantages and disadvantages related to these new working practices have been recognized by the literature, how these new work practices, widely adopted during the Covid-19 pandemic, have been generally perceived on a massive scale is still unclear. Based on these considerations, this work aims to carry out a big data analysis in order to frame the collective perception about smart working. A large-scale text analytics study has been conducted on Twitter from January to June 2021. The data-driven approach identified the most frequently used macro-concepts about smart working by Twitter’s users: five perceived in a positive way (smartness, work-life balance, flexible approach, productivity, innovative working environment) and five perceived negatively (tech paralysis, technostress, technology hiccups, demotivation, social isolation). In this sense, the study offers several insights by generating useful implications for researchers and professionals both in the organizational design and psychological and Human Resources Management field.
“You look good, I would never tell you are trans!”: A Narrative Review on Microaggressions against Transgender People
Authors: Anzani Annalisa
Published: March 2023

The present article reviews research conducted in the last decade on microaggressions toward transgender and gender non-conforming (TGNC) individuals. In Western culture, overt forms of discrimination have become increasingly less accepted, leaving space for more subtle forms of discrimination. Microaggressions are subtle day-to-day discriminations that are particularly detrimental for psychological health and well-being. After a brief introduction to the key concepts of microaggression theorisation, the present work aims to provide an overview of existing literature that examined TGNC experiences with microaggressions. Implications for psychological work with TGNC people are discussed.
The Invisi_les: Biphobia, Bisexual Erasure and Their Impact on Mental Health
Authors: Pennasilico Andrea , Amodeo Anna Lisa
Published: March 2023

In the last few years, research on lesbian, gay, bisexual, and transgender (LGBT) health increased, but little scientific literature has been focused on bisexual health. This critical review aims at understanding the relationship between discrimination towards bisexual people and their mental and physical health. The first part of the article reviews different forms of bisexual discrimination, such as biphobia, bisexual invisibility, and bi-erasure, showing how biphobia is different from homophobia, especially considering how heavily it is perpetrated inside and outside the community. The second part of the paper focuses on gathering data about bisexual people’s health, showing the differences with the gay and lesbian community, as well as the diverse effects that discrimination can have on physical and mental outcomes. Finally, the last part focuses on the healthcare experiences of bisexual people and what can be done to improve their health.
Improved Superscaling in Quasielastic Electron Scattering with Relativistic Effective Mass
Authors: Casale Paloma Rodriguez , Amaro Jose , Martinez-Consentino Victor , Simo Ignacio Ruiz
Published: March 2023

Superscaling in electron scattering from nuclei is re-examined paying special attention to the definition of the averaged single-nucleon responses. The validity of the extrapolation of nucleon responses in the Fermi gas has been examined, which previously lacked a theoretical foundation. To address this issue, we introduce new averaged responses with a momentum distribution smeared around the Fermi surface, allowing for momenta above the Fermi momentum. This approach solves the problem of negativity in the extrapolation away from the scaling region and, at the same time, validates its use in the scaling analysis. This work has important implications for the interpretation of scaling data and contributes to the development of a more complete understanding of the scaling approach.
Acetaminophen-trace Pharmaceutical Bioremediation using Two Isolated Novel Environment-Friendly Phenotypically/Genotypically-characterized Streptomyces Strains; Chemo-informatics & Experimentally tested for Cytotoxicity & Biological Activity
Authors: Embarez Donia H , Abdel-Razek Ahmed S. , Basalious Emad B. , Mahmoud Magdy , Hamdy Nadia M
Published: March 2023

We report the isolation of two novel degrading bacterial strains active against the potential environmental pollutant acetamino-phen/paracetamol. Streptomyces Chrestomyceticus (RS2) and Streptomyces Flavofuscus (M33) collected from El-Natrun Valley, Egypt, water, sediment, and sand samples were taxonomically characterized via conidiophores morphologic characterization under Trans-mission Electron Microscope (TEM). Genotypic identification, done based on their 16S rRNA gene sequence analysis followed by BLAST alignment and deposited on the NCBI as 2 novel strains. The phylogenetic tree was constructed using an appropriate software. Acetaminophen degradation-products chemical structure was identified by GC/LC MS. The biological antimicrobial activity of some selected acetaminophen degradation-products extracts and derived compounds was examined against panel of test micro-organisms and found to be have high anti-microbial effect. In addition, in silico cheminformatics Swiss ADMET evaluation of these selected deg-radation extract for gastric absorption, distribution, hepatic metabolism, renal excretion as well as distribution to CNS and finally not mutagenic/teratogenic or genotoxic virtually. In vitro cytotoxic activity of these selected bio-degradation products was performed against HepG2 and MCF7 cancer cell lines, revealing that M33 and RS2 extract effect on acetaminophen/paracetamol bio-degradation products are potentially safe with higher IC50 on HepG2 and MCF7, in comparison to acetaminophen/paracetamol with IC50 of 108.5 μg/ml. Moreover, the in vivo acute oral single dose toxicity experiment was conducted, being compared with acetamino-phen/paracetamol to confirm that the bio-degradation products have lower toxicity than acetaminophen in vivo and in silico.
Sarcoidosis, Mycobacterium paratuberculosis and Noncaseating Granulomas: Who Moved My Cheese
Authors: Dow Coad Thomas , Lin Nancy W. , Chan Edward D.
Published: March 2023

Clinical and histological similarities between sarcoidosis and tuberculosis have driven repeated investigations looking for a mycobacterial cause of sarcoidosis. Over 50 years ago “anonymous mycobacteria” were suggested to have a role in the etiology of sarcoidosis. Both tuberculosis and sarcoidosis have a predilection for lung involvement though each can be found in any area of the body. A key histopathologic feature of both sarcoidosis and tuberculosis is the granuloma – while the tuberculous caseating granuloma has an area of caseous necrosis with a cheesy consistency; the non-caseating granuloma of sarcoidosis does not have this feature. This article reviews and reiterates the complicity of the infectious agent, Mycobacterium avium ss. paratuberculosis (MAP) as a cause of sarcoidosis. MAP is involved in a parallel story as the putative cause of Crohn’s disease, another disease featuring noncaseating granulomas. MAP is a zoonotic agent infecting ruminant animals and is found in dairy products and in environmental contamination of water and air. Despite increasing evidence tying MAP to several human diseases, there is a continued resistance to embracing its pleiotropic roles. "Who Moved My Cheese" is a simple yet powerful book that explores the ways in which individuals react to change. Extending the metaphor, the “non-cheesy” granuloma of sarcoidosis actually contains the difficult-to-detect “cheese”, MAP; MAP did not move, it was there all along.
Research and Development of Technology for Obtaining Red Food Coloring from Sumac Fruits
Authors: Hafizov Gharib
Published: March 2023

In the East, it has already become a tradition to prepare dry powdered seasonings from the fruits of the sumac plant (Rhus coriaria L.). In this work, we tested their processing by extraction. Sumac was collected in mid-September in a mountain forest near the village of Gezik (Guba, Azerbaijan). Before extraction, it was first dehydrated in a drying cabinet SH-DO-149 FG (Southern Bark) to an air-dry state; then crushed in a Tube Mill control mill (Germany) into pieces of 1-3 mm in size. One- and two-stage maceration extraction was tested together with water or acidified water at temperatures from 20 to 80 °C. Evaporation of primary extracts was carried out in a rotary evaporator Lab Rot 2 L (China). The concentration of coloring substances in the extract (in units of optical density) was used as an output parameter. It was found that the use of two-stage extraction and acidified water with a concentration of citric acid 0.3 g/cm3 contributes to the extraction of the maximum amount of coloring substances and increases the transparency of the resulting extracts, which allows the extracted extracts to be concentrated directly to obtain a new type of natural food dye. The involvement of sumac fruits in industrial processing will increase the need for these medicinal fruits, and this, in turn, will serve as an incentive for the introduction of this medicinal plant into culture.
Applicability of Electrochemical Chloride Extraction to Concrete Made With Different Binders
Authors: Tofeti Lima Thamara
Published: March 2023

The present study concerns the application of electrochemical chloride extraction to concrete designed with partial replacements of Ordinary Portland Cement (OPC) from different binders, namely ground granulated blast furnace (GGBS), pulverized fly ash (PFA) and Silica Fume (SF), to attend the need of corrosion repair for modern constructions. Electrochemical Chloride Extraction (ECE) was applied to the specimens at a current density of 2A/m2 for 4 weeks. The chloride types and binding mechanisms appeared to have important implications on the different performance of treatment perceived for all binders. Considering total chlorides, removal was more significant for OPC and GGBS when compared to others. The main difference noted was that for GGBS the removal of bound chlorides was more significant due to a possible release of adsorbed chlorides from the silicate hydrates, present at higher intensities in this case. However, even though GGBS had greater rates of bound chloride removal it had still the same percentage as OPC for total efficiency due to the fact that in OPC the removal of free chlorides is more expressive.
Characteristic Analysis and Structural Design of Photonic Crystal Fibers for Gas Sensing Applications
Authors: Zheng Longchao , LIU YONG
Published: March 2023

A total internal reflection photonic crystal fiber (PCF) based on hexagonal core is proposed for gas sensing in a specific wavelength range. The higher sensitivity and lower confinement loss were realized by the structure of the proposed PCF consists of two layers with circular holes rotated hexagonally around a core region and six slotted air-hole in the cladding based on numerical analysis. The simulation results show that the enhancement of the relative sensitivity has been done by enhancing the diameter of the hexagonal shape air-hole cladding (d1) and the hexagonal arranged holes around the central solid core (d0) in this design. Also, the confinement loss has been reduced by enhancing the ratio of length to width of slotted holes (l/w) and decreasing the cladding air-hole diameters (d1). As the refractive index increases, the wavelength shifts toward the long wavelength. And in a certain temperature range, the transmission characteristics of the device does not change with the temperature. The results are helpful for designing high performance PCF for gas sensing applications.
Expression of HNP1 gene in children with atopic dermatitis
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Svitich O.A. ,   I.I.Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation, Soboleva V.A.. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   I.I.Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation, Abramova N.D. ,   I.I.Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation, Gelezhe K.A. ,   I.I.Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation, Kudryavtseva A.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   I.I.Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation
Published: March 2023

The expression of innate immune genes, defensins, changes in atopic dermatitis (AD). There has been much research on β-defensins, whereas the role of α-defensins in AD has not been adequately examined. Objective. To evaluate the expression of HNP1 gene in affected and visually unaffected skin areas in patients with different clinical and morphological forms of AD. Patients and methods. The participants in this study (n = 103) were patients admitted to the Maternity and Childhood Center of Sechenov University in 2020–2022. Two skin scraping samples were obtained from each of the patients with AD (n = 89), from skin areas affected and not affected by AD; one skin scraping sample was obtained from control group participants (n = 14) with no skin diseases. To determine the expression of HNP1 in skin cells, a real-time reverse transcription polymerase chain reaction followed by statistical analysis was performed. Results. A significant increase in the expression of HNP1 gene was demonstrated in a more severe course of AD with the development of lichenoid skin changes. The elevated expression level of this antimicrobial peptide indicates the development of inflammatory reactions involving neutrophils in the inflammation area, possibly associated with colonization of the affected skin by opportunistic bacterial pathogens. Conclusion. The α-defensin HNP1 plays an important role in disease progression and can subsequently be used in the treatment of AD as a highly effective alternative approach. Key words: atopic dermatitis, children, neutrophil peptide 1, HNP1
Probiotics and probiotic products for children with intestinal disorders
Authors:   Veltischev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University, Moscow Moscow, Russian Federation, Khavkin A.I. , Gurova M.M. ,   Belgorod State National Research University, Belgorod, Russian Federation,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Novikova V.P. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Vashura A.Yu. ,   Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
Published: March 2023

This article outlines current concepts of probiotic drugs and probiotic foods for children, provides the list of gastrointestinal disorders in children that can be considered as indications for probiotics, as well as their mechanism of action. Particular attention is paid to probiotic use according to the criteria of evidence-based medicine. The review also focuses on the positive role of the probiotic strain Bifidobacterium animalis subsp. lactis in the treatment and prevention of gastroenterological disorders in children, both as part of pharmacotherapy and enriched food products. Key words: intestinal microbiota, dysbiosis, Bifidobacterium animalis subsp. lactis, probiotics, probiotic foods for children
Percepción del tamaño corporal actual y deseado en la niñez temprana
Authors: León González María Pilar , González-Martí Irene , López Sánchez Guillermo Felipe , Contreras Jordán Onofre Ricardo
Published: March 2023

La imagen corporal es un constructo de relevancia social dada su repercusión en la salud física y mental. La investigación de este constructo en edades tempranas ha recibido escasa atención a pesar de que algunos autores han demostrado que existe preocupación hacia el cuerpo en edad preescolar. Este estudio de diseño mixto tuvo como objetivo medir la percepción del tamaño corporal, el cuerpo deseado y la insatisfacción corporal en niños de edad temprana. Para ello, se utilizó la Escala Corporal para Preescolares, compuesta de cuatro figuras de niños con diferentes estados de peso, la cual fue administrada a 176 participantes de 4 y 5 años, de los cuales 96 fueron chicos y 80 fueron chicas. Los resultados mostraron que la percepción del tamaño corporal fue inexacta en ambos sexos y edades, tendiendo hacia una mayor sobreestimación en las niñas. También se observó que la mayoría de los participantes eligieron una figura deseada diferente a la percibida, especialmente el sexo femenino. Sin embargo, este hallazgo no necesariamente reflejaría la existencia de insatisfacción corporal, como sugieren los datos cualitativos. Las respuestas de los participantes parecen reflejar una ligera conciencia corporal. Se necesitan futuros estudios que ahonden más en el desarrollo de la imagen corporal en edades tempranas.
Automatic Identification System (AIS) data case study : vessel traffic through the Yaquina Bay breakwater at Newport, Oregon
Authors: Kress Marin
Published: March 2023

The navigation staff at US Army Corps of Engineers (USACE) Portland District (NWP) asked for information on vessel transits through the two existing openings in the breakwater on the north side of Yaquina Bay in Newport, Oregon. Currently, no authorized federal channel passes through the breakwater openings; however, the design for a possible federal channel is under consideration. NWP staff were interested in historical vessel transits, with a special focus on isolating transits for the largest (i.e., longest) vessels, identified as vessels 80 feet or longer, currently utilizing the area inside the breakwater. The Automatic Identification System Analysis Package (AISAP) software created by USACE-ERDC (2018) was used to analyze vessel traffic.
Hima Sumac. Drama en tres actos y en prosa
Authors: Matto de Turner Clorinda
Published: March 2023

Hima Sumac revitaliza una leyenda inca cuya protagonista es una mujer, quien desmitifica la imagen femenina, ya que, si bien se enamora, luego se reivindica en su lecho de muerte. Matto intenta en esta obra dramatúrgica, generar una toma de conciencia sobre la identidad nacional y muestra la fortaleza del indígena para que este sea tratado como parte integral del país incluyendo el quechua, y muestra que el Perú está configurado por diferentes etnias que son parte del proyecto de nación.
An Immunostimulatory Glycolipid That Blocks
SARS-CoV-2, RSV, and Influenza Infections In Vivo
Authors: Ho David , Tsuji Moriya , Nair Manoj , Masuda Kazuya , Castagna Candace , Chong Zhenlu , Darling Tamarand , Seehra Kuljeet , Ribeiro Ágata , Ferreira Geovane , Corredor Laura , Coelho-dos-Reis Jordana Alves , Tsuji Yukiko , Boon Adrianus , Diamond Michael , Huang Yaoxing , Hwang Youngmin , Mori Munemasa
Published: March 2023

The fear and devastation caused by the COVID-19 pandemic has been mitigated by the successful development and deployment of prophylactic vaccines that substantially lowered the incidences of symptomatic infection, hospitalization, and death. However, as the causative agent SARS-CoV-2 continues to spread and evolve worldwide, vaccine-breakthrough infections have become frequent, especially after the emergence of viral variants that are antigenically distant from the ancestral strain used in the current vaccines. Additional approaches are therefore needed in our prevention tool kit. Here, we report on a glycolipid termed 7DW8-5 that exploits the host innate immune system to enable rapid control of viral infections in vivo. This glycolipid binds to CD1d on antigen-presenting cells and thereby stimulates NKT cells to release a cascade of cytokines and chemokines. The intranasal administration of 7DW8-5 prior to virus exposure significantly blocked infection by three different authentic variants of SARS-CoV-2, as well as by respiratory syncytial virus and influenza virus, in mice or hamsters. We also found that this protective antiviral effect is both host-directed and mechanism-specific, requiring both the CD1d molecule and interferon- gamma. A chemical compound like 7DW8-5 that is easy to administer and cheap to manufacture may be useful not only in slowing the spread of COVID-19 but also in responding to future pandemics that include currently ongoing influenza, SARS-CoV-2 and respiratory syncytia virus- associated tripledemic long before vaccines or drugs are developed.
Knowledge, Attitude and Worry in the Kurdistan Region of Iraq During the Mpox (Monkeypox) Outbreak in 2022: An Online Cross-sectional Study
Authors: Ahmed Sirwan Khalid , Abdulqadirb Salar Omar , Omar Rukhsar Muhammad , Abdullah Ardalan Jabbar , Rahman Hawre Asaad , Hussein Safin Hassan , M-Amin Halkawt Ismail , Chandran Deepak , Sharma Anil K. , Dhama Kuldeep , Salam Malik , Harapan Harapan , Salari Nader , Chakraborty Chiranjib , Abdulla Araz Qadir
Published: March 2023

The rapid spread of monkeypox (mpox) has been declared as a Public Health Emergency of International Concern (PHEIC). The present study aimed to assess the knowledge, attitude, and worry levels of the general population in the Kurdistan Region of Iraq regarding the ongoing mpox multi-country outbreak. An online cross-sectional survey was conducted between July 27 and July 30, 2022, using a convenience sampling method. The questionnaire was adapted from previous studies addressing the same topic. The independent Student t-test, one-way ANOVA, and logistic regression were used to assess possible factors associated with knowledge, attitude, and worry toward mpox. A total of 510 respondents were included in the final analysis. The participants showed moderate level of mpox knowledge, neutral attitude towards mpox, and a relatively moderate worry level. The logistic regression analysis showed that age, gender, marital status, religion, level of education, and place of residence were associated with mpox knowledge; however, the significant variables in the multivariate regression analysis were gender, religion, level of education, and residential area. Gender, and residential area were associated with attitudes toward mpox; however, the significant variables in the multivariate regression analysis were gender and residential areas. The worry toward mpox was influenced by gender, marital status, religion, and place of residence; however, the significant variables in the multivariate regression analysis were gender, religion, educational level and residential area. In conclusion, the Kurdish population had moderate knowledge, a neutral attitude, and a moderate level of worry about mpox. Considering the continuous rapid rise in mpox cases in several countries, and its possible risk as pandemic amid the ongoing COVID-19 pandemic, proactive control measures, adequate disease prevention strategies, and preparedness plans need to be formulated and immediately implemented to tackle the appearance of fears among people, and safeguard the mental health of the public.
Defining of the Supportive Care Needs of Using Hormone Therapy Patients Have Prostate Cancer and Caregivers
Authors: Tanış Esra Uslu , Uğur Özlem
Published: March 2023

Introduction This study aims to describe ways to alleviate the problems faced by prostate cancer patients undergoing using hormone therapy, as well as supporting their caregivers . It also describes the support care service needs of these two groups. Methods: This is a cross-sectional definitive study. The study involved 66 prostate cancer patients and 64 caregivers.
Results 79.9% of the caregivers were female and 43.8 % were patients’ wives. 36% of the patients had 80-90% performance rates on the Karnofsky scale.
9.32% of patients required support for sexual issues before and after the diagnosis, and 46.27% needed supportive care for water retention. Of the caregivers, 40.88% needed family support, and 21.25% needed social services support. It was found that prostate cancer patients receiving hormone therapy and their caregivers had a range of supportive care needs due to the difficulties they faced.
Noninvasive electrophysiological imaging identifies 4D uterine peristalsis patterns in subjects with normal menstrual cycles and patients with endometriosis
Authors: Wang Sicheng , Anderson Kelsey , Pizzella Stephanie , Xu Haonan , Wen Zichao , Lin Yiqi , Nan Yuan , Lau Josephine , Wang Qing , Ratts Valerie , Wang Yong
Published: March 2023

Throughout the menstrual cycle, spontaneous mild contractions in the inner layer of the uterine smooth muscle cause uterine peristalsis, which plays a critical role in normal menstruation and fertility. Disruptions in peristalsis patterns may occur in women experiencing subfertility, abnormal uterine bleeding, ovulatory dysfunction, endometriosis, and other disorders. However, current tools to measure uterine peristalsis in humans have limitations that hamper their research or clinical utilities. Here, we describe an electrophysiological imaging system to noninvasively quantify the four-dimensional (4D) electrical activation pattern during human uterine peristalsis with high spatial and temporal resolution and coverage. We longitudinally imaged 4968 uterine peristalses in 17 participants with normal gynecologic anatomy and physiology over 34 hours and 679 peristalses in 5 participants with endometriosis over 12.5 hours throughout the menstrual cycle. Our data provide quantitative evidence that uterine peristalsis changes in frequency, direction, duration, magnitude, and power throughout the menstrual cycle and is disrupted in endometriosis patients. Moreover, our data suggest that disrupted uterine peristalsis contributes to excess retrograde menstruation and infertility in patients with endometriosis and potentially contributes to infertility in this cohort.
Effectiveness of low-intensity pulsed ultrasound for the treatment of viral pneumonia: study protocol for a prospective, randomized controlled trial
Authors: Li Xiao , Li Wen , Sun Lianjie , Ren Junyi , Xu Ying , Zheng Yuanyi , Bai Wenkun
Published: March 2023

Background: Viral pneumonia has always been a problem faced by clinicians because of its insidious onset, strong infectivity and lack of effective drugs. Patients with advanced age or underlying diseases may experience more severe symptoms and are prone to severe ventilation dysfunction. Reducing pulmonary inflammation and improving clinical symptoms is the focus of current treatment. Low-intensity pulsed ultrasound (LIPUS) can mitigate inflammation and inhibit edema formation. We aimed to investigate the effectiveness of therapeutic LIPUS in improving lung inflammation in hospitalized patients with viral pneumonia.
Methods: This study protocol entails a prospective, randomized controlled trial. 60 eligible participants with clinically confirmed viral pneumoniawill be assigned to either (1) test group (LIPUS stimulus), (2) external control group (null stimulus), or (3) self-control group (LIPUS stimulated areas versus non-stimulated areas). The primary outcome will be the difference in the extent of absorption and dissipation of lung inflammation on computed tomography andultrasonography images. Secondary outcomes include pulmonary function, blood gas analysis, fingertip arterial oxygen saturation, serum inflammatory factor levels, the sputum excretion volume, time to the disappearance of pulmonary rales, pneumonia status score, and course of pneumonia. Adverse events will be recorded. Intention-to-treat analyses will be used.
Discussion: This study is the first clinical study of the effectiveness of therapeutic LIPUS in the treatment of viral pneumonia. Given that the current clinical recovery mainly depends on the body's self-limiting and conventional symptomatic treatment, LIPUS, as a new therapy method, might be a major advance in the treatment of viral pneumonia.
Trial registration: ChiCTR2200059550 Chinese Clinical Trial Registry
Metabolomics in severe traumatic brain injury: a scoping review
Authors: Fedoruk Riley Page , Lee Chel Hee , Banoei Mohammad Mehdi , Winston Brent
Published: March 2023

Background: Diagnosis and prognostication of severe traumatic brain injury (sTBI) continue to be problematic despite research efforts for years. There is currently no clinically reliable biomarkers, though advances in protein biomarkers are being made. Utilizing Omics technology, particularly metabolomics, may provide new diagnostic biomarkers for severe traumatic brain injury. Several published studies have attempted to determine specific metabolites and metabolic pathways involved; these studies will be reviewed.
Aims: This scoping review aims to summarize current literature concerning metabolomics in severe traumatic brain injury, review the comprehensive data and identify commonalities, if any, to define metabolites with potential clinical use. In addition, we will examine related metabolic pathways through pathway analysis.
Methods: Scoping review methodology was used to examine the current literature published in Embase, Scopus, PubMed and Medline. An initial 1090 publications were found and vetted with specific inclusion/exclusion criteria. 20 publications were selected for further examination and summary. Metabolic data was classified using the Human Metabolome Database (HMDB) and arranged to determine the recurrent metabolites and classes found in severe traumatic brain injury. To help understand potential mechanisms of injury, pathway analysis was performed using these metabolites and the Kyoto Encylcopedia of Genes and Genomes (KEGG) Pathway Database.
Results: Several metabolites related to severe traumatic brain injury and their effects on biological pathways are identified in this review. Proline, citrulline, lactate, alanine, valine, leucine and serine were all decreased in adults post severe traumatic brain injury, whereas both octanoic and decanoic acid were increased post injury. Carboxylic acids tend to decrease following severe traumatic brain injury while hydroxy acids and organooxygen compounds tend to increase. Pathway analysis showed significantly affected glycine and serine metabolism, glycolysis, branched chain amino acid (BCAA) metabolism and other amino acid metabolisms. Surprisingly, no tricarboxylic acid cycle metabolites were affected.
Conclusion: Aside from select few metabolites, classification of a metabolic profile proved difficult due to significant ambiguity between study design, type of sample, sample size, metabolomic detection techniques and other confounding variables. Given the trends found in some studies, further metabolomics investigation of severe traumatic brain injury may be useful to identify clinically relevant metabolites.
Caught on camera: Widespread direct evidence of illegal discards in coastal waters of the Western Baltic Sea
Authors: Schubert Philipp Rene , Karez Rolf , Reusch Thorsten B. H.
Published: March 2023

Most fish stocks in the European Union (EU) are still being overfished. One recent measure of the EU common fisheries policy to curb overfishing is the introduction of landing obligations that are meant to reduce discards, but the success of landing obligations is controversial, as discards still take place. In the German Western Baltic Sea , discards are currently estimated using ship observer data, but vessels <12 m are not sufficiently controlled. We here use an independent method and document widespread discard of undersized cod and flatfish in late summer 2018 using video transects. Discards along the coastline of the south-western Baltic Sea amount to an extrapolated 14.0 t of cod and 1.0 t of flatfish decomposing on the sea floor in 1-13 m depth in a subarea of Mecklenburg Bight that covers only 2.3% of ICES (International Council for the Exploration of the Sea ) subdivisions 22-24, the habitat of Western Baltic cod. Compared to a similar video-mapping seven years earlier (in 2011), the amount of discard increased markedly, suggesting that the implementation of landing obligations in the time between the two mappings for under-sized catches has not resulted in a decrease but an increase of discards. We suggest that higher observed discards of cod in 2018 are also due to a high percentage of cod coming from the 2016-cohort of the Western Baltic cod stock which are just undersized but nevertheless caught by most passive net gear. Our data complement estimates based on ship observer data, while providing the first direct evidence of the fate of discards in the benthic marine habitat.
Conducting Health Services Research During the COVID-19 Pandemic: Experiences from the Veterans Health Administration
Authors: Connelly Brigid , Hess Edward , Daus Marguerite , Battaglia Catherine , Gilmartin Heather M.
Published: March 2023

Background Health services researchers within the Veterans Health Administration (VA) seek to improve the delivery of care to the Veteran population, whose medical needs often differ from the general population. The COVID-19 pandemic and restricted access to medical centers and offices forced VA researchers and staff totransition to remote work. This study aimed to characterize the work experience of health service researchers during the COVID-19 pandemic.
Methods A REDCap survey developed from the management literature was distributed in July 2020 to 800 HSR&D researchers and staff affiliated with VA Centers of Innovation. We requested recipients to forward the survey to VA colleagues. Descriptive analyses and logistic regression modeling were conducted on multiple choice and Likert scaled items. Manifest content analysis was conducted on open-text responses.
Results About half (48%; n=228) of VA HSR&D researchers and staff who responded to the survey experienced some interference with their research due to the COVID-19 pandemic, while 55% (n=260) reported their programs of research did not slow or stop. Clinician investigators reported significantly greater odds of interference than non-clinician investigators and support staff. The most common barriers to working remotely were loss of face-to-face interactions with colleagues (56%; n=263) and absence of daily routines (25%; n=118). Strategies teams used to address COVID-19 related remote work challenges included videoconferencing (79%; n=375), virtual get-togethers (48%; n=225), altered timelines (42%; n=199), daily email updates (30%; n=143) and virtual team huddles (16%; n=74). Pre-pandemic VA information technology structures along with systems created to support multidisciplinary research teams working across a national healthcare system maintained and enhanced staff engagement and well-being.
Conclusions
This study identifies how the VA structures and systems put in place prior to the COVID-19 pandemic to support a dispersed workforce enabled the continuation of vital scientific research, staff engagement and well-being during a global pandemic. These findings can inform remote work policies and practices for researchers during the current and future crises.