bluuebunny/crossref_metadata_2025 huggingface dataset:
Titanium in Cast Cu-Sn Alloys—A Review
Authors: Manu Karthik , Jezierski Jan , Ganesh Madikkamadom Radhakrishnan Sai , Shankar Karthik Venkitaraman , Narayanan Sudarsanan Aswath
Published: August 2021

The article reviews the progress made on bronze alloys processed through various casting techniques, and focuses on enhancements in the microstructural characteristics, hardness, tensile properties, and tribological behaviour of Cu-Sn and Cu-Sn-Ti alloys. Copper and its alloys have found several applications in the fields of automobiles, marine and machine tools specifically for propellers in submarines, bearings, and bushings. It has also been reported that bronze alloys are especially used as an anti-wear and friction-reducing material to make high performance bearings for roller cone cock bits and warships for defence purposes. In these applications, properties like tensile strength, yield strength, fatigue strength, elongation, hardness, impact strength, wear resistance, and corrosion resistance are very important; however, these bronze alloys possess only moderate hardness, which results in low wear resistance, thereby limiting the application of these alloys in the automobile industry. The major factor that influences the properties of bronze alloys is the microstructure. Morphological changes in these bronze alloys are achieved through different manufacturing techniques, such as casting, heat treatment, and alloy addition, which enhance the mechanical, tribological, and corrosion characteristics. Alloying of Ti to cast Cu-Sn is very effective in changing the microstructure of bronze alloys. Reinforcing the bronze matrix with several ceramic particles and surface modifications also improves the properties of bronze alloys. The present article reviews the techniques involved in changing the microstructure and enhancing the mechanical and tribological behaviours of cast Cu-Sn and Cu-Sn-Ti alloys. Moreover, this article also reviews the industrial applications and future scope of these cast alloys in the automobile and marine industries.
Effect of Al2Ca Addition and Heat Treatment on the Microstructure Modification and Tensile Properties of Hypo-Eutectic Al–Mg–Si Alloys
Authors: Shah Abdul Wahid , Ha Seong-Ho , Kim Bong-Hwan , Yoon Young-Ok , Lim Hyun-Kyu , Kim Shae K.
Published: August 2021

The current study investigated the microstructure modification in Al–6Mg–5Si–0.15Ti alloy (in mass %) through the minor addition of Ca using Mg + Al2Ca master alloy and heat treatment to see their impact on mechanical properties. The microstructure of unmodified alloy (without Ca) consisted of primary Al, primary Mg2Si, binary eutectic Al–Mg2Si, ternary eutectic Al–Mg2Si–Si, and iron-bearing phases. The addition of 0.05 wt% Ca resulted in significant microstructure refinement. In addition to refinement, lamellar to fibrous-type modification of binary eutectic Al–Mg2Si phases was also achieved in Ca-added (modified) alloy. This modification was related to increasing Ca-based intermetallics/compounds in the modified alloy that acted as nucleation sites for binary eutectic Al–Mg2Si phases. The dendritic refinement with Ca addition was related to the fact that it improves the efficacy of Ti-based particles (TiAl3 and TiB2) in the melt to act as nucleation sites. In contrast, the occupation of oxide bifilms by Ca-based phases is expected to force the iron-bearing phases (as iron-bearing phases nucleate at oxide films) to solidify at lower temperatures, thus reducing their size. The as-cast microstructure of these alloys was further modified by subjecting them to solution treatment at 540 °C for 6 h, which broke the eutectic structure and redistributed Mg2Si and Si phases in Al-matrix. Subsequent aging treatment caused a dramatic increase in the tensile strength of these alloys, and tensile strength of 291 MPa (with El% of 0.45%) and 327 MPa (with El% of 0.76%) was achieved for the unmodified alloy and modified alloy, respectively. Higher tensile strength and elongation of the modified alloy than unmodified alloy was attributed to refined dendritic structure and modified second phases.
Solution of Inhomogeneous Fractional Differential Equations with Polynomial Coefficients in Terms of the Green’s Function, in Nonstandard Analysis
Authors: Morita Tohru , Sato Ken-ichi
Published: August 2021

Discussions are presented by Morita and Sato in Mathematics 2017; 5, 62: 1–24, on the problem of obtaining the particular solution of an inhomogeneous ordinary differential equation with polynomial coefficients in terms of the Green’s function, in the framework of distribution theory. In the present paper, a compact recipe in nonstandard analysis is presented, which is applicable to an inhomogeneous ordinary and also fractional differential equation with polynomial coefficients. The recipe consists of three theorems, each of which provides the particular solution of a differential equation for an inhomogeneous term, satisfying one of three conditions. The detailed derivation of the applications of these theorems is given for a simple fractional differential equation and an ordinary differential equation.
Approximation of Fixed Points of Multivalued Generalized (α,β)-Nonexpansive Mappings in an Ordered CAT(0) Space
Authors: Abbas Mujahid , Iqbal Hira , De la Sen Manuel , Ahmad Khushdil
Published: August 2021

The purpose of this article is to initiate the notion of monotone multivalued generalized (α,β)-nonexpansive mappings and explore the iterative approximation of the fixed points for the mapping in an ordered CAT(0) space. In particular, we employ the S-iteration algorithm in CAT(0) space to prove some convergence results. Moreover, some examples and useful results related to the proposed mapping are provided. Numerical experiments are also provided to illustrate and compare the convergence of the iteration scheme. Finally, an application of the iterative scheme has been presented in finding the solutions of integral differential equation.
Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
Authors: Jun Se-Ran , Boerma Marjan , Udaondo Zulema , Richardson Sasha , Thrall Karla D. , Miousse Isabelle R. , Seng John , Pathak Rupak , Hauer-Jensen Martin
Published: August 2021

The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic and gastrointestinal (GI) systems. To identify new pathways involved in radiation-induced GI injury, this study assessed dose- and time-dependent changes in plasma metabolites in a nonhuman primate model of whole abdominal irradiation. Male and female adult Rhesus monkeys were exposed to 6 MV photons to the abdomen at doses ranging between 8 and 14 Gy. At time points from 1 to 60 days after irradiation, plasma samples were collected and subjected to untargeted metabolomics. With the limited sample size of females, different discovery times after irradiation between males and females were observed in metabolomics pattern. Detailed analyses are restricted to only males for the discovery power. Radiation caused an increase in fatty acid oxidation and circulating levels of corticosteroids which may be an indication of physiological stress, and amino acids, indicative of a cellular repair response. The largest changes were observed at days 9 and 10 post-irradiation, with most returning to baseline at day 30. In addition, dysregulated metabolites involved in amino acid pathways, which might indicate changes in the microbiome, were detected. In conclusion, abdominal irradiation in a nonhuman primate model caused a plasma metabolome profile indicative of GI injury. These results point to pathways that may be targeted for intervention or used as early indicators of GI radiation injury. Moreover, our results suggest that effects are sex-specific and that interventions may need to be tailored accordingly.
Using Porcine Jejunum Ex Vivo to Study Absorption and Biotransformation of Natural Products in Plant Extracts: Pueraria lobata as a Case Study
Authors: Houriet Joëlle , Arnold Yvonne E. , Pellissier Léonie , Kalia Yogeshvar N. , Wolfender Jean-Luc
Published: August 2021

Herbal preparations (HPs) used in folk medicine are complex mixtures of natural products (NPs). Their efficacy in vivo after ingestion depends on the uptake of the active ingredient, and, in some cases, their metabolites, in the gastrointestinal tract. Thus, correlating bioactivities measured in vitro and efficacy in vivo is a challenge. An extract of Pueraria lobata rich in different types of isoflavones was used to evaluate the capacity of viable porcine small intestine ex vivo to elucidate the absorption of HP constituents, and, in some cases, their metabolites. The identification and transport of permeants across the jejunum was monitored by liquid chromatography-mass spectrometry (LC-MS), combining targeted and untargeted metabolite profiling approaches. It was observed that the C-glycoside isoflavones were stable and crossed the intestinal membrane, while various O-glycoside isoflavones were metabolized into their corresponding aglycones, which were then absorbed. These results are consistent with human data, highlighting the potential of using this approach. A thorough investigation of the impact of absorption and biotransformation was obtained without in vivo studies. The combination of qualitative untargeted and quantitative targeted LC-MS methods effectively monitored a large number of NPs and their metabolites, which is essential for research on HPs.
A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes
Authors: Vigers Tim , Vanderlinden Lauren A. , Johnson Randi K. , Carry Patrick M. , Yang Ivana , DeFelice Brian C. , Kaizer Alexander M. , Pyle Laura , Rewers Marian , Fiehn Oliver , Norris Jill M. , Kechris Katerina
Published: August 2021

Environmental factors including viruses, diet, and the metabolome have been linked with the appearance of islet autoimmunity (IA) that precedes development of type 1 diabetes (T1D). We measured global DNA methylation (DNAm) and untargeted metabolomics prior to IA and at the time of seroconversion to IA in 92 IA cases and 91 controls from the Diabetes Autoimmunity Study in the Young (DAISY). Causal mediation models were used to identify seven DNAm probe-metabolite pairs in which the metabolite measured at IA mediated the protective effect of the DNAm probe measured prior to IA against IA risk. These pairs included five DNAm probes mediated by histidine (a metabolite known to affect T1D risk), one probe (cg01604946) mediated by phostidyl choline p-32:0 or o-32:1, and one probe (cg00390143) mediated by sphingomyelin d34:2. The top 100 DNAm probes were over-represented in six reactome pathways at the FDR <0.1 level (q = 0.071), including transport of small molecules and inositol phosphate metabolism. While the causal pathways in our mediation models require further investigation to better understand the biological mechanisms, we identified seven methylation sites that may improve our understanding of epigenetic protection against T1D as mediated by the metabolome.
Detection of Electrical Circuit in a Thin-Film-Transistor Liquid-Crystal Display Using a Hybrid Optoelectronic Apparatus: An Array Tester and Automatic Optical Inspection
Authors: Tzu Fu-Ming , Chen Jung-Shun , Hsu Shih-Hsien
Published: August 2021

In this study, we developed a high-resolution, more accurate, non-destructive apparatus for refining the detection of electrode pixels in a thin-film-transistor liquid-crystal display (TFT-LCD). The hybrid optoelectronic apparatus simultaneously uses an array tester linked with the automatic optical inspection of panel defects. Unfortunately, due to a tiny air gap in the electro-optical inspector, the situation repeatedly causes numerous scratches and damages to the modulator; therefore, developing alternative equipment is necessary. Typically, in TFT-LCDs, there are open, short, and cross short electrical defects. The experiment utilized a multiple-line scan with the time delay integration (TDI) of a charge-coupled device (CCD) to capture a sharp image, even under low light, various speeds, or extreme conditions. In addition, we explored the experimental efficacy of detecting the electrode pixel of the samples and evaluated the effectiveness of a 7-inch opaque quartz mask. The results show that an array tester and AOI can detect a TFT-LCD electrode pixel sufficiently; therefore, we recommend adopting the hybrid apparatus in the TFT-LCD industry.
Towards the Forest Virome: High-Throughput Sequencing Drastically Expands Our Understanding on Virosphere in Temperate Forest Ecosystems
Authors: Rumbou Artemis , Vainio Eeva J. , Büttner Carmen
Published: August 2021

Thanks to the development of HTS technologies, a vast amount of genetic information on the virosphere of temperate forests has been gained in the last seven years. To estimate the qualitative/quantitative impact of HTS on forest virology, we have summarized viruses affecting major tree/shrub species and their fungal associates, including fungal plant pathogens, mutualists and saprotrophs. The contribution of HTS methods is extremely significant for forest virology. Reviewed data on viral presence in holobionts allowed us a first attempt to address the role of virome in holobionts. Forest health is dependent on the variability of microorganisms interacting with the host tree/holobiont; symbiotic microbiota and pathogens engage in a permanent interplay, which influences the host. Through virus–virus interplays synergistic or antagonistic relations may evolve, which may drastically affect the health of the holobiont. Novel insights of these interplays may allow practical applications for forest plant protection based on endophytes and mycovirus biocontrol agents. The current analysis is conceived in light of the prospect that novel viruses may initiate an emergent infectious disease and that measures for the avoidance of future outbreaks in forests should be considered.
Minimal Associations between Short-Term Dietary Intake and Salivary Microbiome Composition
Authors: Kim Judith , Lee Minyi , Baldwin-Hunter Brittany , Solfisburg Quinn S. , Lightdale Charles J. , Korem Tal , Hur Chin , Abrams Julian A.
Published: August 2021

Background: Increasing evidence points to the esophageal microbiome as an important co-factor in esophageal neoplasia. Esophageal microbiome composition is strongly influenced by the oral microbiome. Salivary microbiome assessment has emerged as a potential non-invasive tool to identify patients at risk for esophageal cancer, but key host and environmental factors that may affect the salivary microbiome have not been well-defined. This study aimed to evaluate the impact of short-term dietary intake on salivary microbiome composition. Methods: Saliva samples were collected from 69 subjects prior to upper endoscopy who completed the Automated Self-Administered 24-Hour (ASA24) Dietary Assessment. Salivary microbiome composition was determined using 16S rRNA amplicon sequencing. Results: There was no significant correlation between alpha diversity and primary measures of short-term dietary intake (total daily calories, fat, fiber, fruit/vegetables, red meat intake, and fasting time). There was no evidence of clustering on beta diversity analyses. Very few taxonomic alterations were found for short-term dietary intake; an increased relative abundance of Neisseria oralis and Lautropia sp. was associated with high fruit and vegetable intake, and an increased relative abundance of a taxon in the family Gemellaceae was associated with increased red meat intake. Conclusions: Short-term dietary intake was associated with only minimal salivary microbiome alterations and does not appear to have a major impact on the potential use of the salivary microbiome as a biomarker for esophageal neoplasia.
Genomic Insights into Drug Resistance Determinants in Cedecea neteri, A Rare Opportunistic Pathogen
Authors: Thompson Dorothea K. , Sharkady Stephen M.
Published: August 2021

Cedecea, a genus in the Enterobacteriaceae family, includes several opportunistic pathogens reported to cause an array of sporadic acute infections, most notably of the lung and bloodstream. One species, Cedecea neteri, is associated with cases of bacteremia in immunocompromised hosts and has documented resistance to different antibiotics, including β-lactams and colistin. Despite the potential to inflict serious infections, knowledge about drug resistance determinants in Cedecea is limited. In this study, we utilized whole-genome sequence data available for three environmental strains (SSMD04, M006, ND14a) of C. neteri and various bioinformatics tools to analyze drug resistance genes in this bacterium. All three genomes harbor multiple chromosome-encoded β-lactamase genes. A deeper analysis of β-lactamase genes in SSMD04 revealed four metallo-β-lactamases, a novel variant, and a CMY/ACT-type AmpC putatively regulated by a divergently transcribed AmpR. Homologs of known resistance-nodulation-cell division (RND)-type multidrug efflux pumps such as OqxB, AcrB, AcrD, and MdtBC were also identified. Genomic island prediction for SSMD04 indicated that tolC, involved in drug and toxin export across the outer membrane of Gram-negative bacteria, was acquired by a transposase-mediated genetic transfer mechanism. Our study provides new insights into drug resistance mechanisms of an environmental microorganism capable of behaving as a clinically relevant opportunistic pathogen.
Mineralogy and Magnetic Behavior of Yellow to Red Xuanhua-Type Agate and Its Indication to the Forming Condition
Authors: Zhou Danyi , Shi Guanghai , Liu Suzhen , Wu Bailing
Published: August 2021

Iron oxides/hydroxides are important magnetic minerals to provide information about changes in the forming environment. However, the magnetic behavior in agate has been rarely investigated. In this study, the magnetic behavior of the Xuanhua-type agate with intense yellow to red colors from the Xuanhua District (China) was investigated by temperature dependence of magnetic susceptibility, hysteresis loop, isothermal remanent magnetization and the analysis of remanent coercivity components from the gradient acquisition plot. Yellow goethite and red hematite can be quantitatively identified by XRD and Raman spectroscopy due to their relatively higher content. Results showed that the red, yellow and orange Xuanhua-type agate had different magnetic behavior, and magnetite existed in the yellow and orange ones. Fluid inclusions in such agate had the homogenization temperature of ~168 °C to 264 °C. All results suggested that the dehydration of goethite to form hematite was the main reason for the high remnant coercivity (above 1000 mT) of hematite in the red agate. The co-existence of magnetite and goethite in the yellow and orange agate reflects the transformation from Fe2+ to Fe3+, indicating the change in the redox property of the environment. Unique patterns mainly formed by hematite and goethite make it a popular gem-material with high research value.
Torque Analysis of a Gyratory Crusher with the Discrete Element Method
Authors: Moncada Manuel , Toledo Patricio , Betancourt Fernando , Rodríguez Cristian G.
Published: August 2021

Comminution by gyratory crusher is the first stage in the size reduction operation in mineral processing. In the copper industry, these machines are widely utilized, and their reliability has become a relevant aspect. To optimize the design and to improve the availability of gyratory crushers, it is necessary to calculate their power and torque accurately. The discrete element method (DEM) has been commonly used in several mining applications and is a powerful tool to predict the necessary power required in the operation of mining machines. In this paper, a DEM model was applied to a copper mining gyratory crusher to perform a comprehensive analysis of the loads in the mantle, the crushing torque, and crushing power. A novel polar representation of the radial forces is proposed that may help designers, engineers, and operators to recognize the distribution of force loads on the mantle in an easier and intuitive way. Simulations with different operational conditions are presented and validated through a comparison with nominal data. A calculation procedure for the crushing power of crushers is presented, and recommendations for the selection of the minimum resolved particle size are given.
Experimental Study on Mechanical Properties of Paste Backfill with Flue-Gas Desulphurisation Gypsum under Combined Action of Dry–Wet Cycles and Chloride Erosion
Authors: Wang Sheng , Wang Feng , Yin Dawei , Jiang Tianqi , Zhang Zhen
Published: August 2021

Flue-gas desulphurisation gypsum—a solid waste from power plants—can be used to prepare paste backfill for reducing costs. Most paste backfills are exposed to dry–wet cycles and chloride salt-rich water in mines. Therefore, the mechanical properties and damage mechanisms of paste backfill with desulphurised gypsum under the coupling action of erosion due to chloride with different concentrations and dry–wet cycles were investigated using methods such as visual observation, mass measurement, uniaxial compression, acoustic emission, Fourier-transform infrared spectroscopy, X-ray diffraction analysis, and field-emission scanning electron microscopy. With an increasing number of dry–wet cycles, the mass, elastic modulus, and strength of the paste backfill exhibited the trend of increasing first and then decreasing. The failure mechanism changed from mainly vertical fractures to the alternating development of vertical and horizontal fractures. The surface denudation effect of the specimens in a solution with a higher concentration was more severe under the same number of dry–wet cycles. In this study, the laws governing the mass change, strength change, degree of surface denudation, and failure pattern of desulphurised gypsum-filled specimens under different concentrations of chloride salt and different numbers of dry–wet cycles were derived.
Design of Multifaceted Antioxidants: Shifting towards Anti-Inflammatory and Antihyperlipidemic Activity
Authors: Tzara Ariadni , Lambrinidis George , Kourounakis Angeliki
Published: August 2021

Oxidative stress and inflammation are two conditions that coexist in many multifactorial diseases such as atherosclerosis and neurodegeneration. Thus, the design of multifunctional compounds that can concurrently tackle two or more therapeutic targets is an appealing approach. In this study, the basic NSAID structure was fused with the antioxidant moieties 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHB), its reduced alcohol 3,5-di-tert-butyl- 4-hydroxybenzyl alcohol (BHBA), or 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox), a hydrophilic analogue of α-tocopherol. Machine learning algorithms were utilized to validate the potential dual effect (anti-inflammatory and antioxidant) of the designed analogues. Derivatives 1–17 were synthesized by known esterification methods, with good to excellent yields, and were pharmacologically evaluated both in vitro and in vivo for their antioxidant and anti-inflammatory activity, whereas selected compounds were also tested in an in vivo hyperlipidemia protocol. Furthermore, the activity/binding affinity of the new compounds for lipoxygenase-3 (LOX-3) was studied not only in vitro but also via molecular docking simulations. Experimental results demonstrated that the antioxidant and anti-inflammatory activities of the new fused molecules were increased compared to the parent molecules, while molecular docking simulations validated the improved activity and revealed the binding mode of the most potent inhibitors. The purpose of their design was justified by providing a potentially safer and more efficient therapeutic approach for multifactorial diseases.
Charge-Transfer Process in Surface-Enhanced Raman Scattering Based on Energy Level Locations of Rare-Earth Nd3+-Doped TiO2 Nanoparticles
Authors: Zhao Zihao , Zhao Xiang , Zhang Mu , Sun Xudong
Published: August 2021

Surface-enhanced Raman scattering (SERS) for semiconductor nanomaterial systems is limited due to weak Raman signal intensity and unclear charge-transfer (CT) processes for chemical enhancement. Here, rare-earth element neodymium-doped titanium dioxide (Nd-TiO2) nanoparticles (NPs) were synthesized by the sol–gel method. The characterizations show that the doping of Nd ions causes TiO2 NPs to show an increase in the concentration of defects and change in the energy level structure. The CT process between Nd-TiO2 NPs substrate and probe molecule 4-Mercaptopyridine (4-Mpy) was innovatively analyzed using the relative energy level location relationship of the Dorenbos model. The SERS signal intensity exhibits an exponential enhancement with increasing Nd doping concentration and reaches its optimum at 2%, which is attributed to two factors: (1) The increase in the defect concentration is beneficial to the CT process between the TiO2 and the probe molecule; (2) the introduction of 4f electron orbital energy levels of rare-earth ions created unique CT process between Nd3+ and 4-Mpy. Moreover, the Nd-TiO2 NPs substrate shows excellent SERS performance in Raman signal reproducibility (RSD = 5.31%), the limit of detection (LOD = 10−6 M), and enhancement factor (EF = 3.79 × 104). Our work not only improves the SERS performance of semiconductor substrates but also provides a novel approach to the development of selective detection of probe molecules.
Environmentally Compatible Lead-Free Perovskite Solar Cells and Their Potential as Light Harvesters in Energy Storage Systems
Authors: Jeon Il , Kim Kyusun , Jokar Efat , Park Minjoon , Lee Hyung-Woo , Diau Eric Wei-Guang
Published: August 2021

Next-generation renewable energy sources and perovskite solar cells have revolutionised photovoltaics research and the photovoltaic industry. However, the presence of toxic lead in perovskite solar cells hampers their commercialisation. Lead-free tin-based perovskite solar cells are a potential alternative solution to this problem; however, numerous technological issues must be addressed before the efficiency and stability of tin-based perovskite solar cells can match those of lead-based perovskite solar cells. This report summarizes the development of lead-free tin-based perovskite solar cells from their conception to the most recent improvements. Further, the methods by which the issue of the oxidation of tin perovskites has been resolved, thereby enhancing the device performance and stability, are discussed in chronological order. In addition, the potential of lead-free tin-based perovskite solar cells in energy storage systems, that is, when they are integrated with batteries, is examined. Finally, we propose a research direction for tin-based perovskite solar cells in the context of battery applications.
Nano-Enable Materials Promoting Sustainability and Resilience in Modern Agriculture
Authors: Ur Rahim Hafeez , Qaswar Muhammad , Uddin Misbah , Giannini Cinzia , Herrera Maria Lidia , Rea Giuseppina
Published: August 2021

Intensive conventional agriculture and climate change have induced severe ecological damages and threatened global food security, claiming a reorientation of agricultural management and public policies towards a more sustainable development model. In this context, nanomaterials promise to support this transition by promoting mitigation, enhancing productivity, and reducing contamination. This review gathers recent research innovations on smart nanoformulations and delivery systems improving crop protection and plant nutrition, nanoremediation strategies for contaminated soils, nanosensors for plant health and food quality and safety monitoring, and nanomaterials as smart food-packaging. It also highlights the impact of engineered nanomaterials on soil microbial communities, and potential environmental risks, along with future research directions. Although large-scale production and in-field testing of nano-agrochemicals are still ongoing, the collected information indicates improvements in uptake, use efficiency, targeted delivery of the active ingredients, and reduction of leaching and pollution. Nanoremediation seems to have a low negative impact on microbial communities while promoting biodiversity. Nanosensors enable high-resolution crop monitoring and sustainable management of the resources, while nano-packaging confers catalytic, antimicrobial, and barrier properties, preserving food safety and preventing food waste. Though, the application of nanomaterials to the agri-food sector requires a specific risk assessment supporting proper regulations and public acceptance.
Editorial for the Special Issue on “10th Anniversary of Nanomaterials—Recent Advances in Nanocomposite Thin Films and 2D Materials”
Authors: Sort Jordi , Rius Gemma
Published: August 2021

As a way to celebrate the 10th anniversary of the journal Nanomaterials, this Special Issue within the section ‘Nanocomposite thin film and 2D materials’ provides an overview of the wide spectrum of research challenges and applications in the field, represented by a collection of 12 contributions, including three up-to-date review articles plus nine original works, in different targeted topics as described below [...]
Advantages of InGaN–GaN–InGaN Delta Barriers for InGaN-Based Laser Diodes
Authors: Cheng Liwen , Li Zhenwei , Zhang Jiayi , Lin Xingyu , Yang Da , Chen Haitao , Wu Shudong , Yao Shun
Published: August 2021

An InGaN laser diode with InGaN–GaN–InGaN delta barriers was designed and investigated numerically. The laser power–current–voltage performance curves, carrier concentrations, current distributions, energy band structures, and non-radiative and stimulated recombination rates in the quantum wells were characterized. The simulations indicate that an InGaN laser diode with InGaN–GaN–InGaN delta barriers has a lower turn-on current, a higher laser power, and a higher slope efficiency than those with InGaN or conventional GaN barriers. These improvements originate from modified energy bands of the laser diodes with InGaN–GaN–InGaN delta barriers, which can suppress electron leakage out of, and enhance hole injection into, the active region.
Atomic Resolution Electron Microscopy: A Key Tool for Understanding the Activity of Nano-Oxides for Biomedical Applications
Authors: Azor-Lafarga Alberto , Gómez-Recio Isabel , Ruiz-González M. Luisa , González-Calbet José M.
Published: August 2021

Transition metal oxides constitute one of the most fruitful sources of materials with continuously increasing potential applications prompted by the expectations derived from the reduction of the particle size. The recent advances in transmission electron microscopy, because of the development of lenses, have made it possible to reach atomic resolution, which can provide answers regarding the performance of the transition metal nano-oxides. This critical information is related not only to the ability to study their microstructural characteristics but also their local composition and the oxidation state of the transition metal. Exploring these features is a well-known task in nano-oxides for energy and electronic technologies, but they are not so commonly used for elucidating the activity of these oxides for biomedical applications. Nevertheless, the identification at the atomic level of a certain dopant or the unambiguous determination of the oxidation state of a transition metal in a nano-oxide can be important questions to be answered in a certain biomedical application. In this work, we provide several examples in transition metal nano-oxides to show how atomic-resolution electron microscopy can be a key tool for its understanding.
Measuring Athletes’ Perception of the Sport Nutrition Information Environment: The Adaptation and Validation of the Diet Information Overload Scale among Elite Athletes
Authors: Kiss Anna , Soós Sándor , Tompa Orsolya , Temesi Ágoston , Lakner Zoltán
Published: August 2021

The exponentially growing quantity of nutrition information creates a new situation and challenge for every stakeholder, from athletes, coaches and nutritionists to policymakers. To measure the perception of the information environment related to healthy eating, the diet information overload scale was developed. The scale consists of eight items, measuring the perceived importance of pieces of information overload on Likert-type scales. The objective of the study was to test the applicability and validity of the diet information overload scale among athletes. A cross-sectional validation study was conducted with elite athletes (n = 177). To validate each item of the scale, we applied Cronbach’s alpha test, and the inner consistency of the scale was analyzed with linear correlation coefficients of the different variables. To evaluate the relationship between question groups, we applied factor analysis. The different fit indices showed a good fit to the model; the Root Mean Square Error of Approximation (RMSEA) value was 0.09 and the Tucker–Lewis index (TLI) value was 0.84. The indicators of reliability (α based upon the covariances = 0.81) produced suitable results; thus, the sport nutrition information overload scale showed high reliability and applicability. Based on the sport nutrition information overload scale, further analysis could be carried out on how to optimize the content of key pieces of sport nutrition-related information.
TMPRSS6 rs855791 Polymorphism Status in Children with Celiac Disease and Anemia
Authors: Urbaszek Klaudia , Drabińska Natalia , Szaflarska-Popławska Anna , Jarocka-Cyrta Elżbieta
Published: August 2021

Celiac disease (CD) is an autoimmune chronic inflammatory disease occurring in genetically predisposed individuals in response to the intake of gluten. Clinical presentation can be heterogeneous. Iron-deficient anemia (IDA) is one of the most common extra-intestinal manifestations of CD. Although IDA usually reverts with a gluten-free diet (GFD), some patients show persistent IDA, the mechanisms of which are poorly understood. Recent studies suggest an association between the rs855791 polymorphism in the TMPRSS6 gene and persistent IDA in adults with CD. The current study aimed to assess the potential link between rs855791 and persistent IDA in pediatric patients with CD. The study included 106 children diagnosed with CD between 2015 and 2019. Clinical and blood parameters (including blood count, serum iron) were collected at diagnosis and after ≥12 months of GFD, and the rs855791 genotype was assessed for each patient. IDA was present at diagnosis in 25 patients (23.6%); only three (3%) had persistent IDA after GFD. The prevalence of rs855791 genotypes was 9% (n = 10) for TT, 53% (n = 56) for CT, and 38% (n = 40) for CC. There was a tendency toward a higher proportion of the T allele in patients with IDA and lower hemoglobin in the TT genotype but without statistical significance. An association between rs855791 and persistent IDA was not observed. These findings suggest that persistent IDA is uncommon in pediatric patients with CD. The prevalence of rs855791 in children with CD is reported for the first time.
Two Dimensions of Nutritional Value: Nutri-Score and NOVA
Authors: Romero Ferreiro Carmen , Lora Pablos David , Gómez de la Cámara Agustín
Published: August 2021

Front-of-pack labels can improve the ability of consumers to identify which foods are healthier, making them a useful public health tool. Nutri-Score is a front-of-pack labelling system adopted by several European countries. This system ranks foods according to their nutritional quality, but does not consider other dimensions such as the degree of food processing. The aim of this study is to compare the nutritional quality (as assessed by Nutri-Score) and the ultra-processing (as assessed by the NOVA classification) of foods in the Open Food Facts database. A simple correspondence analysis was carried out to study the relationship between the two systems. Ultra-processed foods (NOVA 4) were found in all Nutri-Score categories, ranging from 26.08% in nutritional category A, 51.48% in category B, 59.09% in category C, 67.39% in category D to up to 83.69% in nutritional category E. Given the negative effect that the consumption of ultra-processed foods has on different aspects of health, front-of-pack labelling with Nutri-Score should at least be accompanied by complementary labelling indicating the level of processing, such as the NOVA classification.
Exploring the Mechanisms of Recovery in Anorexia Nervosa through a Translational Approach: From Original Ecological Measurements in Human to Brain Tissue Analyses in Mice
Authors: Duriez Philibert , Nilsson Ida A. K. , Le Thuc Ophelia , Alexandre David , Chartrel Nicolas , Rovere Carole , Chauveau Christophe , Gorwood Philip , Tolle Virginie , Viltart Odile
Published: August 2021

Anorexia nervosa (AN) is a severe eating disorder where caloric restriction, excessive physical activity and metabolic alterations lead to life-threatening situations. Despite weight restoration after treatment, a significant part of patients experience relapses. In this translational study, we combined clinical and preclinical approaches. We describe preliminary data about the effect of weight gain on the symptomatology of patients suffering from acute AN (n = 225) and partially recovered (n = 41). We measured more precisely physical activity with continuous cardiac monitoring in a sub-group (n = 68). Using a mouse model, we investigated whether a long-term food restriction followed by nutritional recovery associated or not with physical activity may differentially impact peripheral and central homeostatic regulation. We assessed the plasma concentration of acyl ghrelin, desacyl ghrelin and leptin and the mRNA expression of hypothalamic neuropeptides and their receptors. Our data show an effect of undernutrition history on the level of physical activity in AN. The preclinical model supports an important role of physical activity in the recovery process and points out the leptin system as one factor that can drive a reliable restoration of metabolic variables through the hypothalamic regulation of neuropeptides involved in feeding behavior.
The Prophylactic Effects of Glutamine on Muscle Protein Synthesis and Degradation in Rats with Ethanol-Induced Liver Damage
Authors: Xiao Qian , Chen Yi-Hsiu , Pratama Satwika Arya , Chen Ya-Ling , Shirakawa Hitoshi , Peng Hsiang-Chi , Yang Suh-Ching
Published: August 2021

The purpose of this research was to investigate the prophylactic effects of glutamine on muscle protein synthesis and degradation in rats with ethanol-induced liver injury. For the first 2 weeks, Wistar rats were divided into two groups and fed a control (n = 16) or glutamine-containing diet (n = 24). For the following 6 weeks, rats fed the control diet were further divided into two groups (n = 8 per group) according to whether their diet contained no ethanol (CC) or did contain ethanol (CE). Rats fed the glutamine-containing diet were also further divided into three groups (n = 8 per group), including a GG group (glutamine-containing diet without ethanol), GE group (control diet with ethanol), and GEG group (glutamine-containing diet with ethanol). After 6 weeks, results showed that hepatic fatty change, inflammation, altered liver function, and hyperammonemia had occurred in the CE group, but these were attenuated in the GE and GEG groups. Elevated intestinal permeability and a higher plasma endotoxin level were observed in the CE group, but both were lower in the GE and GEG groups. The level of a protein synthesis marker (p70S6K) was reduced in the CE group but was higher in both the GE and GEG groups. In conclusion, glutamine supplementation might elevate muscle protein synthesis by improving intestinal health and ameliorating liver damage in rats with chronic ethanol intake.
Influence of COVID-19 Pandemic Restrictions on College Students’ Dietary Quality and Experience of the Food Environment
Authors: Silva Francilia Brito , Osborn Dawn E. , Owens Meghan R. , Kirkland Tracie , Moore Carolyn E. , Patterson Mindy A. , Tucker Wesley J. , Miketinas Derek C. , Davis Kathleen E.
Published: August 2021

The COVID-19 pandemic restrictions sent college students online and off campus, potentially reducing access to healthy food. The objective of this cross-sectional, internet-based study was to use qualitative and quantitative survey methods to evaluate whether COVID-19 pandemic restrictions in Texas, USA affected college students’ ability to buy food, how/what they shopped for, how they prepared food, what they ate, how they felt about eating, and overall dietary quality (assessed using Healthy Eating Index [HEI] scores). Survey responses from 502 students (87.5% female; 59.6% nonwhite, mean age 27.5 ± 0.4 years, >50% graduate students) were analyzed. The qualitative analysis of open-ended questions revealed 110 codes, 17 subthemes, and six themes. Almost all students experienced changes in at least one area, the most common being changes in shopping habits. Participants with low or very low food security had lower HEI scores compared to food secure students (p = 0.047). Black students were more likely to report changes in their ability to buy food (p = 0.035). The COVID-19 restrictions varied in their impact on students’ ability to access sufficient healthy food, with some students severely affected. Thus, universities should establish procedures for responding to emergencies, including identifying at-risk students and mobilizing emergency funds and/or food assistance.
Clinical Outcomes after Oat Beta-Glucans Dietary Treatment in Gastritis Patients
Authors: Gudej Sylwia , Filip Rafał , Harasym Joanna , Wilczak Jacek , Dziendzikowska Katarzyna , Oczkowski Michał , Jałosińska Małgorzata , Juszczak Małgorzata , Lange Ewa , Gromadzka-Ostrowska Joanna
Published: August 2021

The prevalence of gastritis in humans is constantly growing and a prediction of an increase in this health problem is observed in many countries. For this reason, effective dietary therapies are sought that can alleviate the course of this disease. The objective of this study was to determine the effect of chemically pure oat beta-glucan preparations with different molar masses, low or high, used for 30 days in patients with histologically diagnosed chronic gastritis. The study enrolled 48 people of both genders of different ages recruited from 129 patients with a gastritis diagnosis. Before and after the therapy, hematological, biochemical, immunological and redox balance parameters were determined in the blood and the number of lactic acid bacteria and SCFA concentrations in the feces. Our results demonstrated a beneficial effect of oat beta-glucans with high molar mass in chronic gastritis in humans, resulting in reduced mucosal damage and healthy changes in SCFA fecal concentration and peripheral blood serum glutathione metabolism and antioxidant defense parameters. This fraction of a highly purified oat beta-glucan is safe for humans. Its action is effective after 30 days of use, which sheds new light on the nutritional treatment of chronic gastritis.
Effect of an Antenatal Lifestyle Intervention on Dietary Inflammatory Index and Its Associations with Maternal and Fetal Outcomes: A Secondary Analysis of the PEARS Trial
Authors: Killeen Sarah Louise , Phillips Catherine M. , Delahunt Anna , Yelverton Cara A. , Shivappa Nitin , Hébert James R. , Kennelly Maria A. , Cronin Martina , Mehegan John , McAuliffe Fionnuala M.
Published: August 2021

We investigated the effect of an antenatal lifestyle intervention of a low-glycaemic index (GI) diet and physical activity on energy-adjusted dietary inflammatory index (E-DIITM) and explored its relationship with maternal and child health in women with overweight and obesity. This was a secondary analysis of 434 mother−child pairs from the Pregnancy Exercise and Nutrition Study (PEARS) trial in Dublin, Ireland. E-DIITM scores were calculated for early (10–16 weeks) and late (28 weeks) pregnancy. Outcomes included lipids, inflammation markers, insulin resistance, mode of delivery, infant size, pre-eclampsia, and gestational diabetes. T-tests were used to assess changes in E-DIITM. Chi-square, correlations, and multiple regression were employed to investigate relationships with outcomes. The mean (SD) age of participants was 32.45 (4.29) years with median (IQR) BMI 28.25 (26.70, 31.34) kg/m2. There was no change in E-DIITM in the controls (−0.14 (1.19) vs. −0.07 (1.09), p = 0.465) but E-DIITM reduced by 10% after the intervention (0.01 (1.07) vs −0.75 (1.05), p < 0.001). No associations were found between early pregnancy E-DIITM and maternal and child outcomes, except for increased odds of adverse cardiometabolic phenotype in women who delivered male (OR = 2.29, p = 0.010) but not female infants (OR = 0.99, p = 0.960). A low-GI antenatal intervention can reduce the inflammatory potential of diets. Sex differences should be explored further in future research.
Establishment of a Rhesus Macaque Model for Scrub Typhus Transmission: Pilot Study to Evaluate the Minimal Orientia tsutsugamushi Transmission Time by Leptotrombidium chiangraiensis Chiggers
Authors: Linsuwanon Piyada , Wongwairot Sirima , Auysawasdi Nutthanun , Monkanna Taweesak , Richards Allen L. , Leepitakrat Surachai , Sunyakumthorn Piyanate , Im-Erbsin Rawiwan , Poole-Smith Katie , McCardle Patrick
Published: August 2021

Recently, an intradermal inoculation of the rhesus macaque model of scrub typhus has been characterized at our institution. The current project was to establish a rhesus macaque model of scrub typhus using the naturally infected chigger challenge method that faithfully mimics the natural route of pathogen transmission to fully understand the host-pathogen-vector interactions influencing pathogen transmission. Unlike the needle-based inoculation route, Orientia tsutsugamushi-infected chiggers introduce both pathogen and chigger saliva into the host epidermis at the bite site. However, information on the interaction or influence of chigger saliva on pathogenesis and immunity of host has been limited, consequently hindering vaccine development and transmission-blocking studies. To characterize chigger inoculated O. tsutsugamushi in rhesus macaques, we determined the minimum chigger attachment time required to efficiently transmit O. tsutsugamushi to the immunocompetent hosts and preliminary assessed clinical parameters, course of bacterial infection, and host’s immunological response to identifying potential factors influencing pathogen infection. Chigger infestation on hosts resulted in: (i) Rapid transmission of O. tsutsugamushi within 1 h and (ii) antigen-specific type I and II T-cell responses were markedly increased during the acute phase of infection, suggesting that both systems play critical roles in response to the pathogen control during the primary infection. In summary, we demonstrate that O. tsutsugamushi infection in rhesus macaques via chigger challenge recapitulates the time of disease onset and bacteremia observed in scrub typhus patients. Levels of proinflammatory cytokines and chemokines were positively correlated with bacteremia.