bluuebunny/crossref_metadata_2025 huggingface dataset:
Importance of tides and winds in influencing the nonstationary behaviour of coastal currents in offshore Singapore
Authors: Puah Jun Yu , Haigh Ivan D. , Lallemant David , Morgan Kyle , Peng Dongju , Watanabe Masashi , Switzer Adam D.
Published: October 2024

Abstract. Coastal currents significantly impact port activities, coastal landform morphodynamics, and ecosystem functioning. It is therefore necessary to understand the physical characteristics and natural variability of these currents within coastal settings. Traditional methods, such as harmonic analysis, assume stationarity of tide-driven currents and may thus not be applicable to systems modulated by variable nontidal inputs and processes. Here we deployed eight tilt current meters in shallow (< 5 m) coral reef environments in southern Singapore. Tilt current meters were positioned around the reefs at the main compass bearings to analyse the spatiotemporal variability of coastal currents in the frequency domain for 1 year (March 2018 to March 2019). Tidal motions were the primary mechanism of current flow on reefs and account for between 14 % and 45 % of total variance across all sites, with diurnal currents having either a similar or greater proportion of energy compared to semidiurnal currents. The relationship between currents and wind stress was then investigated across various frequencies. There is high correlation at low frequencies during the northeast monsoon, when the Madden–Julian Oscillation (MJO) is more active, thus generating currents that propagate either in phase or ahead of the MJO. At diurnal frequencies, the interaction between P1 and K1 results in a semi-annual cycle where currents are stronger during the monsoon seasons. This interaction could help to explain the seasonal variation in correlation as well as the K1 amplitude, the latter of which could be further enhanced by the diurnal wind stress. The phase relationship between currents and wind stress is highly complex due to the variable bathymetry and could only be partially accounted for by the orientation of the coastlines relative to that of the wind. Given the importance of wind, we thus require longer time-series datasets to examine the role of atmospheric phenomena at greater timescales to improve our understanding of the variability of coastal currents.
Efficacy and safety of Dapagliflozin and Glimepiride in combination with Metformin: Randomized clinical trial
Authors: Yousuf Muhammad Kamran , Memon Khalid Mustafa , Jaffri Muhammad Sajid Abbas , Fatima Mehr , Arslaan Mamoora , Junejo Shizma
Published: October 2024

Objective: To identify the effective treatment option between dapagliflozin-metformin and glimepiride-metformin combination in patients with type 2 diabetes who were inadequately controlled with metformin monotherapy.
 
Study design and setting: The present study is randomized, conducted for 12 weeks at the National Medical center, Karachi, Pakistan.
 
Methodology: The patients were divided into 2 treatment groups; group A was given dapagliflozin-metformin combination, while group B was given glimepiride-metformin combination. The efficacy endpoint of groups was estimated by hemoglobin A1c and fasting blood glucose levels at 0-, 6- and 12-week. While, safety endpoints were identified by analyzing liver function tests, lipid profile tests, renal function test, and urine analysis. The significant difference of data was analyzed by using statistical package of social sciences (SPSS) version 25. The parametric t-test and paired t-test were performed and considered p-value = 0.05 as statistical significant.
 
Results: Baseline demographics, clinical features of diabetes, levels of liver enzymes, liver function test, renal function test, lipid profile, and urinalysis of randomized patients were similar in both treatment groups by showing p = 0.05. Followed by the initiation of the respective treatment, the baseline change of mean FBG and hemoglobin A1c levels with dapagliflozinmetformin combination was shown significantly reduce more compared to glimepiride-metformin combination (p = 0.05). Conclusion: Dapagliflozin-metformin combination therapy was superior and well-tolerated to regulate glycemic control as compare to glimepiride-metformin combination
Pioneers of Capitalism – A Response
Authors: Prak Maarten , Van Zanden Jan Luiten
Published: October 2024

The aim of Pioneers of Capitalism was to provide a synthesis of the research that has been done over the past 25 years by the Utrecht social and economic history group, in particular, and by scholars in this field more generally. The framework was the capitalism debate that has received much attention recently. What does the Dutch case tell us about capitalism as an economic and socio-political system?
Introduction to the Debate on Pioneers of Capitalism
Authors: Blondé Bruno , Spliet Bas
Published: October 2024

On 30 June 2023, the Centre for Urban History at the University of Antwerp, the Posthumus Institute, and the Antwerp Interdisciplinary Platform for Research into Inequality hosted a workshop dedicated to Pioneers of Capitalism. The Netherlands 1000-1800, a book by Maarten Prak and Jan Luiten van Zanden published by Princeton University Press in 2022. Participants in the workshop were challenged to reflect on the broader geographical applicability of the ‘coordinated market’ variety of capitalism that Prak and Van Zanden see emerging in the Dutch Republic after the Fall of Antwerp in 1585. Both during the workshop and in this special issue, the participants engaged in a lively, stimulating discussion with the authors of Pioneers in Capitalism.
Ações de enfermagem para pacientes adultos com estoma intestinal devido a neoplasia maligna: revisão de escopo
Authors: Josino Higor Mateus , Moura Nicole Francinne Marques , Barbosa Thallita Claudia Moraes , Oliveira Patrícia  Peres de , Fonseca Deborah Franscielle da , Moraes Juliano Teixeira
Published: October 2024

Objetivo: Mapear as evidências científicas sobre as principais ações de enfermagem direcionados a adultos com estoma intestinal devido a neoplasia maligna. Método: Trata-se de uma revisão de escopo realizada de julho de 2021 a janeiro de 2022 em seis bases de dados e sete catálogos de teses e dissertações. Nenhum limite temporal foi aplicado. Foram encontrados 1.064 estudos, dos quais 31 abordaram a atuação do enfermeiro no manejo de estomas intestinais. A amostra final foi composta por 25 estudos que atendiam ao objetivo deste trabalho: 22 artigos e três dissertações. Resultados: De acordo com as evidências encontradas, as principais intervenções de enfermagem para os pacientes submetidos à cirurgia de confecção de estoma foram: orientação, incentivo ao autoconhecimento, manejo de equipamento coletor, avaliação de efeitos ou complicações relacionadas a estoma e demarcação do melhor local por enfermeiro especializado. Conclusão: As estratégias de suporte e reabilitação da pessoa com estoma devem ser iniciadas desde o momento da entrada do paciente e sua família no ambiente hospitalar, priorizando o autocuidado, aprendizagem contínua no domicílio e em grupos de apoio, com a finalidade de ajudar tanto o paciente quanto à sua família.
Pasos hacia la revolución: el surgimiento de los paradigmas y la evolución intelectual de Kuhn (1949-1961)
Authors: Mayoral de Lucas Juan V.
Published: October 2024

En este artículo, muestro dos fases reconocibles del desarrollo filosófico de Thomas S. Kuhn desde sus primeras concepciones de su teoría hasta una etapa casi final de la preparación de The Structure of Scientific Revolutions. Uno de sus principales objetivos es mostrar cómo aparece el concepto de paradigma. Otro de dichos objetivos es mostrar que ese itinerario tuvo fases que respondían a problemas diferentes, por lo que el camino hacia los paradigmas no fue por completo lineal, y los conceptos previos no son una simple anticipación de la noción de paradigma.
MetroSonus. Una alternativa incluyente para la formación y la dirección de músicos con discapacidad visual
Authors: Gaitán Lozano Diego Felipe , Reina Zambrano Juanita
Published: October 2024

MetroSonus surge como resultado de una investigación que tiene como propósito la creación de una propuesta para el desarrollo de una herramienta tecnológica que propende por la inclusión de personas con discapacidad visual en los espacios de formación musical, ya sea como aprendiz, como músico parte de un ensamble o como orientador o director. Esta herramienta pedagógica transmite el pulso del director de orquesta a dispositivos móviles en red, con el fin de apoyar los procesos de enseñanza aprendizaje, así como de interpretación de la música.
La orientación metodológica de este proyecto se encuentra apoyada, desde el enfoque cualitativo, en la propuesta de Investigación Praxeológica desarrollada por UNIMINUTO, que tiene como eje la reflexión sobre la práctica y a la vez delimita el proceso investigativo en cuatro momentos: Ver, Juzgar, Actuar, y Devolución creativa.
Este proyecto de investigación plantea nuevos desafíos y exigencias de formación en las diversas áreas, que fueron exploradas para el desarrollo de metroSonus, así como también en el campo de la educación inclusiva y en aquellas que se hacen necesarias para dar continuidad a este proyecto, como es el caso del computer visión, el machine learning y la inteligencia artificial.
Civil wind bands beyond music education: a scoping review (2010-2021)
Authors: Cidade José , Caramelo João , Sá Costa Alexandra
Published: October 2024

The aim of the present study is to provide a comprehensive scoping review focused on the educational effects of active music-making participation in wind bands. This review combines mapping studies to identify the primary sources, authors, institutions, and types of evidence available in wind band research and a literature review to identify the key concepts underpinning this research domain. Based on peer-review journal literature published between 2010 and 2021, a total of 712 records were examined, resulting in 459 papers screened and 84 studies included in the analysis. Findings indicate that, in the past decade, the essential contribution to research about active music-making participation in wind bands came from Western English-speaking academic institutions based in the United States of America, Australia, the United Kingdom and Canada. The research’s relevant focus was on the purposes of music education and the psychosocial and health effects of participation. Furthermore, the psychosocial effects encompassed a comprehensive set of themes, such as social bonding, community music participation, emotional well-being, and individual quality of life. Nevertheless, all these topics are closely linked to the single overarching expression of the quality of life. Other than music education, educational effects were not at the heart of the last decade of wind band research. A few gaps in the literature exist, including a lack of research concerning the educational benefits of informal and intergenerational environments of wind band practices. Equally important is the lack of research on the impacts of wind band activities on social cohesion or the inclusive intercultural development of their local communities. Lastly, there is a significant opportunity to provide up-to-date insights into the educational potential of non-school contexts and the impacts of wind band activities on supporting their places’ cultural ecology.
Percepciones del profesorado de música sobre un nuevo software para la evaluación de la entonación en instrumentos musicales. Un estudio de validación
Authors: Tejada Jesús , Murillo Adolf , Morant Nvasquillo Remigi , Bernabé Villodre María del Mar , Fernández Vilar María Ángeles
Published: October 2024

La entonación es una habilidad imprescindible en el aprendizaje de instrumentos musicales, sobre todo en los de entonación variable, como los de viento-metal y cuerda frotada. Un problema frecuente es que el alumnado principiante encuentra muchas dificultades de entonación en estos instrumentos durante su aprendizaje. Por ello, dedica una gran cantidad de tiempo a su práctica, al igual que el profesorado en la corrección de los errores relacionados. Este estudio de validación es parte de uno de más largo alcance que ha diseñado e implementado un software (INTON, nombre ficticio) para evaluar a tiempo real la entonación en el aprendizaje de instrumentos de cuerda frotada y de viento metal. Para conocer si este software daba respuesta a las necesidades educativas detectadas, se ha realizado un estudio de validación basado en cuestionario que fue cumplimentado por profesorado de escuelas de música y conservatorios de España y Chile (n=41). El cuestionario incluyó tres dimensiones de validación (técnica, educativa y global). Una dimensión sobre uso de tecnología digital educativa, así como experiencia profesional, género, edad y formación profesional actuaron como covariables para analizar la influencia en las dimensiones de validación. Los resultados cuantitativos fueron triangulados con los cualitativos recogidos en dos grupos focales (n=10) con el fin de dotar de credibilidad a la interpretación de los resultados. Los resultados indican que INTON ha sido evaluado de manera muy positiva por el profesorado en las tres dimensiones de validación; se han producido correlaciones positivas entre las tres dimensiones, así como una correlación positiva entre el uso de tecnología digital educativa y la valoración del software. Los resultados de esta validación del software INTON respaldan su eficacia y utilidad para el desarrollo de la entonación en instrumentos de viento-metal y cuerda frotada en el nivel inicial de los estudios musicales.
O ensino de Matemática em uma perspectiva dialógica: um curso sobre a Educação de Jovens e Adultos para licenciandos
Authors: Marinho de Almeida Aline , Ribeiro da Gama Rangel Ingrid
Published: October 2024

A Educação de Jovens e Adultos (EJA) nem sempre é entendida e desenvolvida de forma adequada. Muitas vezes, ela é tomada como medida compensatória quando, na verdade, é um direito social. O presente artigo tem o objetivo de investigar as contribuições do desenvolvimento da dialogicidade freireana, por meio de um curso extracurricular, na formação inicial de docentes de Matemática para atuação na EJA. O curso foi desenvolvido no Instituto Federal Fluminense (IFF), campus Campos Centro, com nove licenciandos em Matemática que integravam o Programa de Residência Pedagógica da Capes de 2020. A elaboração e a aplicação do curso embasaram-se na concepção pedagógica Progressista Libertadora, fundamentada por Paulo Freire. A metodologia utilizada foi aplicada, qualitativa e exploratória. Diante da análise dos resultados, foi possível considerar que o curso promoveu diversas contribuições na formação inicial dos participantes e que há a possibilidade de a formação suscitar novos diálogos em outros contextos.
Os Conselhos e os Fóruns de Educação nas relações intergovernamentais: políticas e planejamento educacional
Authors: Tereza Cestari de Oliveira Regina , Alves da Silva Scaff Elisangela
Published: October 2024

Neste artigo, teve-se como objetivo analisar o papel dos Conselhos e dos Fóruns de Educação, como instâncias de participação social, que integram as relações intergovernamentais no campo das políticas e gestão da educação brasileira, em busca de identificar seus avanços e limites especialmente no que se refere à atuação do Conselho Estadual de Educação e do Fórum Estadual de Educação do Estado de Mato Grosso do Sul nos processos de elaboração, monitoramento e avaliação do Plano Estadual de Educação 2014-2024. A metodologia abrange pesquisa bibliográfica e documental, por meio de consultas às páginas eletrônicas dos diversos órgãos, no período em referência. A análise mostra a participação mais ativa dessas instâncias no processo de elaboração do Plano Estadual e a sua diminuição no processo de monitoramento e avaliação, em uma conjuntura marcada, a partir de 2016, pela fragilidade das relações democráticas brasileiras.
Formação econômica e social brasileira no ensino de Geografia: implementação do novo Ensino Médio na Escola Militar Tiradentes em Mato Grosso
Authors: Figueiredo Junior Jalme Santana de
Published: October 2024

A implementação do Novo Ensino Médio em Mato Grosso representou mudanças significativas na oferta educacional da rede de ensino público de modo geral. A organização dos componentes curriculares em Base Geral, Itinerários Formativos (Trilhas de Aprofundamento, Eletivas e Projeto de Vida) impactaram diretamente nos conceitos e categorias da Geografia que são trabalhadas no Ensino Médio. Esse trabalho resulta de uma problemática de pesquisa na qual se busca compreender o lugar da Geografia dentro de um projeto de ampliação de escolas militares e da implementação do Novo Ensino Médio em Mato Grosso. Para tanto, foram submetidos à análise o Documento de Referência Curricular de Mato Grosso (DRC-MT) Etapa Ensino Médio, articulado à Base Nacional Comum Curricular (BNCC). Esses documentos orientam o trabalho docente a partir de competências e habilidades a partir de eixos de aprendizagem que perpassam pelo conhecimento científico, processos criativos, intervenção sociocultural e empreendedorismo.
Pengaruh Latihan Interval dengan Intensitas Tinggi (HIIT) Terhadap Kapasitas VO2max Pemain Bhayangkara FC U19
Authors: Suliarno Jefri Wibowo , Pamungkas Hari , Kurniawan Rubbi , Nidomuddin Muhammad , Pradipta Anangga Widya
Published: October 2024

Tujuan studi. Penelitian dilakukan untuk membuktikan pengaruh pemberian latihan interval dengan intensitas tinggi (HIIT) terhadap kapasitas VO2max pemain sepak bola.
Bahan dan metode. Eksperimen yang dilakukan dalam penelitian ini berupa HIIT pada pemain sepak bola Bhayangkara FC usia di bawah 19 sebanyak 25 pemain. Pengukuran VO2max dilakukan sebelum dan setelah diberikan perlakuan menggunakan yo-yo intermittent recovery test level 2. Analisis menggunakan paired sample t test dengan bantuan aplikasi SPSS versi 26.
Hasil. hasil uji Paired Sample t-Test menunjukkan nilai signifikansi sebesar 0,00. Nilai ini jauh lebih kecil dari alpha (0,05) yang berarti terdapat perbedaan yang signifikan antara VO2max sebelum dan sesudah diberikan latihan.
Kesimpulan. Penelitian menunjukkan bahwa latihan interval dengan intensitas tinggi (HIIT) secara signifikan mampu meningkatkan VO2max pemain sepak bola Bhayangkara FC U19.
Systematic Method Development and Validation of Paclitaxel and Tamoxifen by RP-HPLC for Simultaneous Estimation in Nanoformulations
Authors: Narwade Mahavir , R. Gajbhiye Kavita
Published: October 2024

Background: Paclitaxel (PTX) is well known anticancer drug used for treatment of a wide range of cancers. Tamoxifen (TMX) is a gold-standard drug for the treatment of breast cancer. They show synergistic action against breast cancer. Quantitative analytical methods are still not available for simultaneous quantification of these drugs. So for the first time, we developed and validated a new systematic analytical technique for simultaneous estimation of PTX and TMX in nanoformulations. Objective: Systematic method development and validation of Paclitaxel and Tamoxifen by RP-HPLC for simultaneous estimation in nanoformulations. Methods: PTX and TMX were successfully separated and quantified using RP-HPLC. The detection was done based on the isobastic point of both drugs. Thermo Scientific Company's C18 column, measuring 2.5 cm × 4.5 cm x 5 µm, was utilized for separation. A 50:50 (vol/vol) ratio of ACN: Phosphate buffer solution (pH 3.0) was employed as the mobile phase, with a flow rate of 1 mL/minute. The detection was done at 235nm. The method was developed and validated as per the criteria. The developed method was then evaluated for applicability by detecting both analytes in prepared SLN and LPHNPs. Results: The well-resolved separate peaks of both analytes were found and distinct RT for PTX and TMX. The linear relationship of both the analytes against concentration was found over the concentration range of 0.25-9 µg/mL. The PTX RT was 10.358 minutes and that of TMX was 12.57 minutes. Every criterion for method validation fell within the acceptable range. The method is precise with inter-day and intra-day precision and shows a %RSD of < 2%.
PCR identification of Enterococcus Species as a Primary Pathogen in Neonatal Bloodstream Infections at Damascus University Paediatric Hospital
Authors: Shbibe Lama , Battah Basem , Walid Kassab Yaman , Javed Qureshi Mohammad , Al-Temimi Ahmed Alaa , Soukkarieh Chadi , aljouda Mayssa
Published: October 2024

Bacterial septicaemia is one of the most common causes of death in newborns throughout the globe. Recently, gram positive bacteria have been detected as a main responsible of hospital acquired blood infection in developed country especially Enterococcus sp. and Staphylococcus sp. This preliminary study aimed to identify Enterococcus species and Staphylococcus species isolated form acquired blood infection in the department of premature and neonates at paediatric university hospital in Damascus, based on PCR technology. the antibiotic sensitivity these pathogens was also investigated against common antibiotics usually used to treat septicaemia in this hospital. Bacterial gDNA was extracted directly from blood samples of children with acquired Septicemia. The bacterial infection was confirmed in 50 samples based on the amplification of 16srDNA gene. Genus Enterococcus sp. and Staphylococcus species were identified as source of infection in samples using specific primers via PCR technique. The antibiotic sensitivity of isolated bacterial strains was studied using Kirby-Bauer disc method. Our study showed that 47 of the 50 samples of the infection were bacterial. The rate of blood infection caused by Enterococcus species was 24%, and 4% for Staphylococcus sp. the isolated bacteria showed a high sensitivity to Amikacin, medium sensitivity to Vancomycin, and less sensitivity to Ampicillin and Gentamycin. Enterococcus species Showed good sensitivity to Amikacin and Vancomycin and low sensitivity to Gentamycin, while was resistant to Ampicillin. Furthermore, the two isolated stains Enterococcus sp and Staphylococcus species showed a good sensitivity against chlorhexidine. This study confirmed the importance of molecular technologies in diagnosing the acquired septicaemia and identifying the specific infectious agent. The molecular test showed that Enterococcus sp. was an important cause of acquired blood infection in neonates respect to ampicillin resistant staphylococcus species.
Designing and Optimization of Microbial Fuel Cell for the production of Bioelectricity
Authors: Thorani Suraksha , Godheja Jai
Published: October 2024

MFC technology is a new type of technology which generates electricity from organic waste with the help of microorganisms by using their metabolic activities. It has now become a promising and efficient technology that converts waste to energy. The present study demonstrates the production of bioelectricity from vegetable waste. Double chambered microbial fuel cell was constructed which was connected with the salt bridge. Bacillus megaterium was used in the MFC which proved to be an efficient microbe for the production of bioelectricity. The maximum power generated was 50Mw using 1% CMC.
Phytochemical profiling and Immunomodulatory activity of belincong (Marsdenia brunoniana) fruit extract against Staphylococcus aureus infection in mice
Authors: Indah Savira Nadyatul Ilma , Irsyad Maulana Alfan , Hasanah Mahfudhotul , Ihsani Zahra Salma , Waluyo Joko , Fikri Kamalia , Wahyuni Dwi , Syifa Fiarani Hajar
Published: October 2024

Marsdenia brunoniana, called belincong, is a wild plant growing in East Java, Indonesia. This study aimed to determine the phytochemical compounds and immunomodulatory activity of M. brunoniana fruit extract. Phytochemical screening of M. brunoniana fruit extract used GC-MS analysis. The immunomodulatory activity of M. brunoniana fruit extract was determined using the number of leukocytes, the weight of the spleen, phagocytic activity, and antibody level. There were 25 mice divided into five groups. Normal control (KN) was the group without any treatment, but negative control (K-) was the group with twice Staphylococcus aureus infection. The M. brunoniana fruit extract treatment groups were differentiated based on dose (P1= 50 mg/kg BW; P2= 100mg/kg BW; P3= 150mg/kg BW). M. brunoniana fruit extract was administered orally for two weeks, and Staphylococcus aureus was injected intraperitoneally after extract administration twice. The GC-MS analysis showed that M. brunoniana fruit extract has 28 compounds. The most compounds in the fruit extract were 1,2,3-Propanetriol (CAS) Glycerol, 1,4-Benzenediol (CAS) Hydroquinone, and Piperidine, 1-methyl- (CAS) N-Methylpiperidine. M. brunoniana fruit extract showed immunomodulatory activity by enhancing phagocytic activity and the weight of the spleen in the P2 group. In addition, the number of leukocytes returned to normal in the P1 group. Not only modulating the innate system, M. brunoniana fruit extract also significantly increased the level of antibodies in mice serum in the P3 group. Based on these results, phytochemical compounds of M. brunoniana fruit extract have immunomodulatory activity against Staphylococcus aureus infection.
Review of The Innovative Medication Delivery System: The Cubosome
Authors: Modi Preet , Patel Harshil , Vaghela Nikita , Patel Urvashi , Naik Priyanshi
Published: October 2024

Cubosomes, also known as bicontinuous cubic phase liquid crystals, are nanoparticles with a specific ratio of amphiphilic lipids as their major constituents. Cubosomes are typically created by hydrating a surfactant or polar lipid that produces a cubic phase and then dispersing it into smaller particles. They operate with solids similar to rheology peculiarities of practical use. They have carvenous (honeycomb) structures that are tightly packed and twisted into three-dimensional bilayers, and they are thermodynamically stable. They can load more drugs because of this type of sophisticated structure. Cubosomes are capable of encapsulating hydrophobic, hydrophilic, and amphiphilic materials. Cubosomes can make drugs that aren't very soluble more soluble. Biocompatible and bioadhesive cubosomes dispersions are available. Due to their characteristics, cubosomes are adaptable systems that can be managed by several ways, including parenterally, percutaneously, and orally. Few researchers have looked into the possibility of cubosomes as delivery methods despite the fact that cubosomes structure has been studied using electron microscopy, light scattering, x-ray, and NMR.
A Review of the effects of Monosodium Glutamate on Gut health
Authors: N Anuradha , Kumar S Saravana , Bindu N Hima , A Gnanavel , S Karthick
Published: October 2024

Monosodium Glutamate (MSG), constitutes a few of the most commonly encountered additives in processed foodstuffs. Its use has grown throughout the years, and consumers are able to recognise it in a wide variety of processed products, as well as ingredients at any stall or grocery shop. Several investigations have challenged its long-term safety, despite the fact it is usually acknowledged as safe by organisations that oversee food safety. The present review details the impact of MSG on gut health and other complications. Increased MSG consumption, and its potential effects on the gastrointestinal system involving glutamatergic neuronal transmission, inflammatory mediators, and gut microbiota have been reviewed in this article. This narrative review has been performed from January 2023 to June 2023 using the literature obtained from databases like Scopus, PubMed, and other databases of The National Library of Medicine, USA. This review may provide further insights into safety issues related to MSG and its use as a food additive or ingredient.
ORAL FINDINGS AND CLINICAL BEHAVIOR IN PATIENT HAVING AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY (APECED)
Authors:   Department of Operative Dentistry and Endodontics, Faculty of Dental Medicine, Medical University of Plovdiv, Bulgaria., Markova Kremena , Simeonov Nikolay ,   Department of Operative Dentistry and Endodontics, Faculty of Dental Medicine, Medical University of Plovdiv, Bulgaria.
Published: October 2024

Introduction: APECED (Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy) is a rare autosomal recessive disease with significant impacts on oral health, including oral candidiasis and varying degrees of enamel hypoplasia. Objective: To present the oral findings of a girl with APECED and the minimally invasive approach taken in recovery and rehabilitation, taking into account the complexity of her medical condition. Material and methods: A case of a 16-year-old girl with APECED, who visited the dental clinic due to defects of the hard dental tissues and severe dentinal hyperesthesia, is described. There was an underbite with a reduced lower facial floor and enamel hypoplasia in the coronal and middle third of the anterior teeth and first molars. Results: Through direct composite restorations and a minimally invasive approach, a good healing, functional and aesthetic result was achieved.
NEGLECTED BOTH-BONE FOREARM FRACTURE WITH DISTAL RADIOULNAR JOINT DISLOCATION: A CASE REPORT AND BRIEF LITERATURE REVIEW
Authors:   Department of Orthopaedics and Traumatology, Faculty of Medicine, Medical University – Pleven, Bulgaria., Simeonov Emil
Published: October 2024

Introduction: In this case, we discuss a patient with a neglected and malunited both-bone forearm fracture with distal radioulnar joint dislocation. This pattern of fracture by itself is uncommon, but the initial negligence of this trauma makes it even more rare and challenging for surgical treatment. Case report: The main aim of the surgery was to restore the forearm's function and anatomy. After thorough preoperative preparation, including planning the level of resections, the patient was treated with open reduction and internal fixation with a limited contact dynamic compression plate. The distal radio-ulnar joint was fixed with 2 K-wires. On control follow-up six months later, the resection sites were fully consolidated, with no visible deformation of the forearm. Pronosupination was restored up to 60% of normal functional arc. Conclusion: This case has shown that even with careful restoration of forearm anatomy, results of the surgical treatment in neglected and malunited both-bone forearm fracture with distal radioulnar dislocation will not be a priori good or excellent. Surgeons need to remind the patients that the return of the function of the upper limb to the degree before the trauma cannot be guaranteed.
Advanced dynamic simulation of soft robotic metamaterials
Authors: Huang Weicheng
Published: October 2024

Soft robotic metamaterials, composed primarily of pliable materials, exhibit mechanically robust maneuvers that surpass the capabilities of conventional rigid robotic systems. However, the design and control of these innovative robots are often hindered by current simulation limitations, necessitating laborious trial-and-error processes. This seminar will introduce state-of-the-art numerical tools designed to enhance the dynamic simulation and control of soft robots, thereby streamlining their development and operational efficiency. In particular, the seminar will focus on addressing three critical challenges inherent to soft robotic systems: managing nonlinear dynamics, facilitating interaction with complex environments, and ensuring real-time responsiveness. Through the integration of advanced simulation techniques, we aim to overcome these obstacles and unlock the full potential of soft robotics. To illustrate the practical applications and benefits of these numerical tools, we will showcase several robotic simulators. These examples include shape-memory-alloy powered soft robots, flagella-inspired robots, magnetic cilia robots, snap-jump robots, and space-tethered net robots. Each simulator will demonstrate the tools' efficiency and effectiveness in real-world scenarios, highlighting their capabilities in both evolutionary design and online control of intelligent robotic systems. The computationally efficient and robust numerical tools presented in this seminar not only serve as benchmarks for the evolutionary design of soft robots but also pave the way for their real-time control in dynamic environments. Attendees will gain insights into the latest advancements in soft robotics simulation and control, equipping them with the knowledge to push the boundaries of what is possible with these cutting-edge technologies.
Ulangan 31-34 Sebagai Teks Reflektif untuk Mengantisipasi Post Power Syndrome bagi Pemimpin Kristen
Authors: Hasibuan Serepina
Published: October 2024

One of the common challenges faced by long-serving leaders, particularly those who are advanced in age, is post-power syndrome. The transition of leadership from Moses to Joshua presents a valuable model for contemporary Christian leaders to emulate in order to avoid this syndrome. This article aims to reflect on the text of Deuteronomy 31–34, which chronicles the concluding phase of Moses' leadership over the Israelites. Utilizing a literature study method, this research examines the text of Deuteronomy 31–34 through a thorough review of books, journal articles, and other relevant documents. The findings indicate that the narrative of Moses' leadership transition to Joshua offers practical guidance for preventing post-power syndrome. Key preventive measures include recognizing one's own limitations and adhering to divine directives, cultivating self-control and humility, prioritizing the welfare of others, and willingly transferring authority with prayer and a sincere blessing for the successor.
Menguak Intoleransi Agama Melalui Penayangan Film His Only Son
Authors: Gea Wasty Prihatin
Published: October 2024

Belakangan ini, publik diramaikan oleh kemunculan film His Only Son yang mengisahkan tentang Abraham yang akan menyembelih putranya, Ishak, di Gunung Moria sebagai bukti ketaatannya pada Allah. Namun, penyebaran film ini di Indonesia telah menimbulkan kontroversi di kalangan masyarakat. Film His Only Son dianggap kontroversial karena tidak sesuai dengan versi kitab suci umat Muslim. Penelitian ini bertujuan untuk menyoroti pentingnya mengimplementasikan sikap toleransi dalam kehidupan antar umat beragama. Upaya untuk memupuk semangat toleransi ini harus dimulai dengan sikap saling menerima dan menghargai perbedaan antar umat beragama. Namun, masih terdapat banyak ketidakadilan dalam praktiknya. Metode penelitian yang digunakan adalah metode studi literatur dengan menganalisis data-data yang ada terkait kontroversi film His Only Son pada dinamika toleransi dan hubungan antar umat beragama di Indonesia. Dengan demikian, penelitian ini diharapkan dapat memberikan wawasan yang berharga untuk mempromosikan sikap toleransi yang lebih inklusif dalam masyarakat yang multikultural. Hasil penelitian ini menunjukkan bahwa sikap penolakan terhadap Film His Only Son merupakan tindakan yang keliru dan menimbulkan sikap intoleransi antar beragama melalui media massa. Penelitian ini mendorong untuk menghidupkan kembali sikap toleransi dalam keberagaman, karena toleransi merupakan aspek fundamental dalam kehidupan beragama.
Invisibilidades e sobrevivências nas memórias de Passarinheiro, de Pedro Weingärtner
Authors: Aquino Camila
Published: October 2024

Este artigo explora a obra Passarinheiro (1893) do pintor gaúcho Pedro Weingärtner (1853-1929), revelando memórias sobre a Florianópolis do século XIX. O texto traz à luz uma tela pouco estudada, que apenas recentemente foi exposta pelo Instituto Collaço Paulo. Busca-se, ainda, relacioná-la ao conceito de memória, demonstrando que a arte pode ser um meio de resistência contra o esquecimento. Nesse sentido, Passarinheiro e o próprio Instituto Collaço Paulo são autênticos lugares de memória.
Athletes Who Consume Creatine Have a Greater Muscle Mass and Sports Performance: A Systematic Review
Authors: Delgado Lorenzo , Haubrick Kevin
Published: October 2024

Creatine monohydrate supplementation is used in numerous sports to enhance an athlete’s performance by improving lean muscle mass. Athletes and men and women, who participate in recreational sports, take creatine before, during, or after training whether they are in the weight room or on the field/court. Creatine can also improve muscle recovery from intense exercise. This systematic review aims to assess the effects of creatine supplementation on an athlete’s muscle mass growth. A literature search was conducted utilizing two databases which included PubMed and Sports Discus. The databases discovered randomized controlled trials published between 2014 to 2024, using combinations of the search terms: “athletes,” “sports,” “athletics,” AND “creatine,” AND “muscle mass,” “hypertrophy,” AND “sports performance.” Reference lists of appropriate studies were manually searched for additional articles. The thirty-three studies offer support for the usage of creatine to improve lean muscle mass and sports performance. The results of this systematic review indicated muscle mass in athletes can increase significantly by creatine supplementation.
Leveraging Technology to Improve and Streamline Operations in the African Construction Sector: A Case-Based Approach
Authors:   American International University, West Africa, The Gambia, Fabiyi Olawale
Published: October 2024

The advent of innovation in tools, materials and techniques has transformed the planning, management and execution of construction projects. Globally, the construction sector has been embracing digital technologies to enhance efficiency, reduce cost and ensure sustainability to overcome challenges and meet evolving demands in the industry. Using a case-based approach, this study shows instances from South Africa of how the construction process is being revolutionised through the deployment of cutting-edge technologies to improve and streamline operations. The approach provides an introductory background on how technology has affected construction with an extensive literature review providing clarifications and insights on construction activities, processes and key technological advancements, in addition to highlighting their importance. Findings from the cases revealed that the projects deployed one or more forms of project management software, such as RIB Software, Autodesk Revit, Primavera P6, Microsoft Project, Procore, and Aconex. It was further found that these deployments enhanced collaboration and communication, improved design coordination and clash detection, and enabled efficient resource allocation and project planning among stakeholders. The study concludes that construction activities play a key role in economic development. Sustainable construction practices would require the adoption and implementation of state-of-the-art technological solutions in the 4th Industrial Revolution that will aid the totality of construction management processes. As evidenced in the various projects, the effectiveness of construction management software in streamlining the construction process is a testament to the critical role of technological advancement as a driver of sustainability.
Perceptions of Public and Private Sector Stakeholders on the Benefits and Challenges of Public-Private-Partnerships in Nigeria
Authors:   University of Lagos, Lagos, Nigeria, Dada Martin , Ogunlana Stephen ,   Heriot Watt University, Edinburgh, Anakor Cecilia ,   Colorado State University, Colorado
Published: October 2024

Nigeria’s infrastructure deficit has become acute because of the country’s burgeoning population. The Public-Private Partnership (PPP) model, under labels such as Private-Finance Initiative (PFI) and Build Operate-Transfer (BOT), has been touted as the solution to the funding and other challenges confronting the country with regard to infrastructure development. This research sought to examine stakeholder experiences and perceptions on the benefits, abuse and challenges of deploying PPP for infrastructure procurement. The stakeholders investigated were in Lagos and Ogun States of Nigeria, although some of the experiences transcended the two states. Copies of the questionnaire were purposively administered to 115 professionals drawn from the built environment as well as from the legal and financial sectors of the Nigerian economy; the professionals were from the private and public sectors. Eighty-six (86) copies of the questionnaire were returned, with the data subjected to descriptive and inferential statistical analyses. Ranking highest among the list of thirteen identified challenges investigated was ‘political interference outside the agreed rules of running the PPP framework’, while ‘inability to initiate or package PPP projects’ ranked least. The most significant form of abuse or disadvantage was ‘embezzling of public funds and reinvesting in PPP as private sector investor’, while the least significant form of abuse was determination of the concession period. The inferential statistical analyses found no significant difference between both sectors in the assessment factors except in the matter of ‘more careful approach in investing funds in infrastructure’. It is therefore recommended that there should be a continuous audit of stakeholder perceptions on various PPP issues that can form the baseline for impactful improvement and intervention in PPP projects.
Clinical implications of reconsideration of enthesitis/enthesopathy/enthesial erosion, as tendon attachment-localized avulsions and stress fracture equivalents
Authors: Rothschild Bruce M
Published: October 2024

Recognizing the mechanical origin of enthesitis/enthesopathy and the avulsion-nature of what had previously been considered erosions, it seems inappropriate to attribute it to stresses related to a person’s normal activities. Conversely, sudden or unconditioned repetitive stresses appears the more likely culprit. Studies of enthesial reaction have lacked standardization as to findings present among individuals who appear to be healthy. Clinical evaluation by palpation and manipulation may be as effective as application of radiologic techniques. Recognition of the mechanical nature of the disease, including individuals with inflammatory arthritis suggests prescription of mechanical solutions that reduce stresses across the involved enthesis.
Application prospects of urine-derived stem cells in neurological and musculoskeletal diseases
Authors: Yang Hui-Si , Zheng Yue-Xiang , Bai Xue , He Xiu-Ying , Wang Ting-Hua
Published: October 2024

Urine-derived stem cells (USCs) are derived from urine and harbor the potential of proliferation and multidirectional differentiation. Moreover, USCs could be reprogrammed into pluripotent stem cells [namely urine-derived induced pluripotent stem cells (UiPSCs)] through transcription factors, such as octamer binding transcription factor 4, sex determining region Y-box 2, kruppel-like factor 4, myelocytomatosis oncogene, and Nanog homeobox and protein lin-28, in which the first four are known as Yamanaka factors. Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic, myogenic, and osteogenic differentiation, indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases. Therefore, we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review, which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs.
Holocene mammals (Insectivora, Rodentia, Chiroptera) of Dollsteinhola Cave, Western Norway
Authors: Stormark Joanna Godawa
Published: October 2024

The Dolisteinhola cave comprises a sequence of Holocene deposits dating from the late Atlanticum to the first half of the Subboreal period. Climate-sensitive species were found in layers V (Sciurus vulgaris) and layers II - III, IV, IV - V (Apodemus flavicollis). Two humerus of Barbastella barbastellus were also recognised. The faunal assemblage were grouped in three climatic complexes: species which lived both in cold and warm climates; species connected with warmer phases of the climate and species typical for a cold climate.
Notes on the spatial distribution of some spider species (Araneae) in a north Norwegian birch forest
Authors: Hauge Erling
Published: October 2024

In June-August 1968 quantitative samples were taken on the ground in the relatively dark Loc.I and the more open Loc.II, in the moss cover from the upper green third (level A) and from the lower two thirds (level B), at Loc.I also in pure leaf litter. For some spider species spatial segregation (vertically and horizontally) is discussed. The A-layer at Loc.I was dominated by the fairly large Hilaira herniosa (33.1 %) and the medium sized Centromerus arcanus (10.3 %), the small sized Tapinocyba pallens was scarce (3.7 %). In total differences were less clear (17.3 - 22.1 %). T. pallens dominated (43.6 %) in the litter samples, the other two were more scarce. T. pallens was scarce at Loc.II (in total 1.1 %). Here the light coloured Diplocentria rectangulata dominated at the B-level (34.4 %), and the dark pigmented Minyriolus pusillus dominated at the A-level (21.5 %). The former was not found at Loc.I, the latter was scarce (totally absent from the litter samples). A small sweep net material from the two field layers indicates some faunal differences compared to the moss and litter.
Abundance of brown bears and wolves in central south Norway after 1733 as revealed by bounty records
Authors: Elgmork Kåre
Published: October 2024

Disbursements for bounties were made locally in Norway from 1733 to 1845 for the killing of brown bears (Ursus arctos) and wolves (Canis lupus). More than 3000 bounty records of these two species from 19 parishes in central south Norway were analysed. The greatest number of bounties paid per unit of area was found in forested areas in the lowland. The number of bounties paid was positively correlated with the size of forested areas and negatively with the density of people and their wealth, represented by the number of cows per inhabitant. The gradient of the regression lines for bounties paid in relation to time in the period 1738 - 1815 was negative, even after correcting for inflation, suggesting that the bounty system caused a slow decrease in the populations of both brown bears and wolves during the 18th century. The introduction of better firearms after about 1850 led to an abrupt decline in the wolf population, which was nearly exterminated around 1870. The brown bear survived a few decades longer, but was also gradually reduced to very small numbers in the beginning of the 20th century.