bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms
Authors: Ran Ruixue , Zhang Chunze , Li Rongshan , Chen Bowei , Zhang Weihua , Zhao Zhenying , Fu Zhiwei , Du Zuo , Du Xiaolang , Yang Xiaolong , Fang Zhongze
Published: November 2016

As one of the main active ingredients from Radix Astragali (RA), orally dosed astragaloside IV (AST) is easily transformed to sapogenin-cycloastragenol (CAG) by deglycosylation in the gastrointestinal tract. Because the potential adverse effects of AST and CAG remain unclear, the present study in this article was carried out to investigate the inhibition effects of AST and CAG on UDP-glucuronosyltransferases (UGTs) to explore potential clinical toxicity. An in vitro UGTs incubation mixture was employed to study the inhibition of AST and CAG towards UGT isoforms. Concentrations of 100 μM for each compound were used to initially screen the inhibitory efficiency. Deglycosylation of AST to CAG could strongly increase the inhibitory effects towards almost all of the tested UGT isoforms, with an IC50 of 0.84 μM and 11.28 μM for UGT1A8 and UGT2B7, respectively. Ulteriorly, the inhibition type and kinetics of CAG towards UGT1A8 and UGT2B7 were evaluated depending on the initial screening results. Data fitting using Dixon and Lineweaver–Burk plots demonstrated that CAG competitively inhibited UGT1A8 and noncompetitively inhibited UGT2B7. From the second plot drawn with the slopes from the Lineweaver–Burk plot versus the concentrations of CAG, the inhibition constant (Ki) was calculated to be 0.034 μM and 20.98 μM for the inhibition of UGT1A8 and UGT2B7, respectively. Based on the [I]/Ki standard ([I]/Ki < 0.1, low possibility; 1 > [I]/Ki > 0.1, medium possibility; [I]/Ki > 1, high possibility), it was successfully predicted here that an in vivo herb–drug interaction between AST/CAG and drugs mainly undergoing UGT1A8- or UGT2B7-catalyzed metabolism might occur when the plasma concentration of CAG is above 0.034 μM and 20.98 μM, respectively.
Synthesis and Pharmacological Evaluation of New 3,4-Dihydroisoquinolin Derivatives Containing Heterocycle as Potential Anticonvulsant Agents
Authors: Zhang Hong-Jian , Shen Qing-Kun , Jin Chun-Mei , Quan Zhe-Shan
Published: November 2016

Two novel series of 3,4-dihydroisoquinolin with heterocycle derivatives (4a–t and 9a–e) were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test. All compounds were characterized by IR, 1H-NMR, 13C-NMR, and mass spectral data. Among them, 9-(exyloxy)-5,6-dihydro-[1,2,4]triazolo[3,4-a]isoquinolin-3(2H)-one (9a) showed significant anticonvulsant activity in MES tests with an ED50 value of 63.31 mg/kg and it showed wide margins of safety with protective index (PI > 7.9). It showed much higher anticonvulsant activity than that of valproate. It also demonstrated potent activity against PTZ-induced seizures. A docking study of compound 9a in the benzodiazepine (BZD)-binding site of γ-aminobutyric acidA (GABAA) receptor confirmed possible binding of compound 9a with the BZD receptors.
Controlled Synthesis of Atomically Layered Hexagonal Boron Nitride via Chemical Vapor Deposition
Authors: Liu Juanjuan , Kutty R. , Liu Zheng
Published: November 2016

Hexagonal boron nitrite (h-BN) is an attractive material for many applications including electronics as a complement to graphene, anti-oxidation coatings, light emitters, etc. However, the synthesis of high-quality h-BN is still a great challenge. In this work, via controlled chemical vapor deposition, we demonstrate the synthesis of h-BN films with a controlled thickness down to atomic layers. The quality of as-grown h-BN is confirmed by complementary characterizations including high-resolution transition electron microscopy, atomic force microscopy, Raman spectroscopy and X-ray photo-electron spectroscopy. This work will pave the way for production of large-scale and high-quality h-BN and its applications as well.
Multi-Layer Identification of Highly-Potent ABCA1 Up-Regulators Targeting LXRβ Using Multiple QSAR Modeling, Structural Similarity Analysis, and Molecular Docking
Authors: Chen Meimei , Yang Fafu , Kang Jie , Yang Xuemei , Lai Xinmei , Gao Yuxing
Published: November 2016

In this study, in silico approaches, including multiple QSAR modeling, structural similarity analysis, and molecular docking, were applied to develop QSAR classification models as a fast screening tool for identifying highly-potent ABCA1 up-regulators targeting LXRβ based on a series of new flavonoids. Initially, four modeling approaches, including linear discriminant analysis, support vector machine, radial basis function neural network, and classification and regression trees, were applied to construct different QSAR classification models. The statistics results indicated that these four kinds of QSAR models were powerful tools for screening highly potent ABCA1 up-regulators. Then, a consensus QSAR model was developed by combining the predictions from these four models. To discover new ABCA1 up-regulators at maximum accuracy, the compounds in the ZINC database that fulfilled the requirement of structural similarity of 0.7 compared to known potent ABCA1 up-regulator were subjected to the consensus QSAR model, which led to the discovery of 50 compounds. Finally, they were docked into the LXRβ binding site to understand their role in up-regulating ABCA1 expression. The excellent binding modes and docking scores of 10 hit compounds suggested they were highly-potent ABCA1 up-regulators targeting LXRβ. Overall, this study provided an effective strategy to discover highly potent ABCA1 up-regulators.
Low-Density Lipoprotein Receptor Contributes to β-Carotene Uptake in the Maternal Liver
Authors: Shete Varsha , Costabile Brianna , Kim Youn-Kyung , Quadro Loredana
Published: November 2016

Vitamin A regulates many essential mammalian biological processes, including embryonic development. β-carotene is the main source of vitamin A in the human diet. Once ingested, it is packaged into lipoproteins, predominantly low-density lipoproteins (LDL), and transported to different sites within the body, including the liver and developing tissues, where it can either be stored or metabolized to retinoids (vitamin A and its derivatives). The molecular mechanisms of β-carotene uptake by the liver or developing tissues remain elusive. Here, we investigated the role of the LDL receptor (LDLr) in β-carotene uptake by maternal liver, placenta and embryo. We administered a single dose of β-carotene to Ldlr+/− and Ldlr−/− pregnant mice via intraperitoneal injection at mid-gestation and monitored the changes in β-carotene content among maternal lipoproteins and the liver, as well as the accumulation of β-carotene in the placental–fetal unit. We showed an abnormal β-carotene distribution among serum lipoproteins and reduced hepatic β-carotene uptake in Ldlr−/− dams. These data strongly imply that LDLr significantly contributes to β-carotene uptake in the adult mouse liver. In contrast, LDLr does not seem to mediate acquisition of β-carotene by the placental–fetal unit.
The Association between Weight Gain/Restoration and Bone Mineral Density in Adolescents with Anorexia Nervosa: A Systematic Review
Authors: El Ghoch Marwan , Gatti Davide , Calugi Simona , Viapiana Ombretta , Bazzani Paola , Dalle Grave Riccardo
Published: November 2016

Background: Reduced bone mineral density (BMD) is one of the most frequent medical complications of anorexia nervosa (AN). The purpose of this paper was to conduct a systematic review of the association between weight gain/restoration and BMD in adolescents with AN. Methods: Literature searches, study selection, method, and quality appraisal were performed independently by two authors, and data were collated using a narrative approach. Results: Of the 1156 articles retrieved, 19 studies met the inclusion criteria, and their analysis revealed four main findings. First, six studies reported that weight gain and restoration are associated with BMD stabilization after one year of follow-up from baseline. Second, seven studies with longer follow-up periods (≈16 months) reported significant improvements in BMD measures. Third, one study showed that normalization of BMD can be achieved after ≈30-month follow-up of normal-weight maintenance. Fourth, another study showed that male adolescents with AN who achieve weight gain but remain underweight may experience further BMD loss, unlike their weight-restored counterparts (BMI ≥ 19 kg/m2), who show a significant increase in BMD and bone mineral accrual rates that double those of healthy male adolescents. The first two findings can be considered robust, as they are supported by strong evidence. The third and fourth findings, however, derive from single studies and therefore require further confirmation. Conclusion: The literature supports weight gain as an effective strategy for promoting BMD increase in adolescents with AN. However, this process is slow, and improvements do not become detectable until ≈16-month follow-up.
Let There Be Light!
Authors: Raykova Doroteya , Koos Björn , Asplund Anna , Gelléri Márton , Ivarsson Ylva , Danielson U. , Söderberg Ola
Published: November 2016

The invention of the microscope has been fundamental for the understanding of tissue architecture and subcellular structures. With the advancement of higher magnification microscopes came the development of various molecular biology tools such as Förster resonance energy transfer (FRET) and in situ proximity ligation assay (in situ PLA) to monitor protein interactions. Microscopy has become a commonly used method for the investigation of molecular events within the cell, for the identification of key players in signaling networks, and the activation of these pathways. Multiple approaches are available for functional analyses in single cells. They provide information not only on the localization of proteins at a given time point, but also on their expression levels and activity states, allowing us to pinpoint hallmarks of different cellular identities within tissues in health and disease. Clever solutions to increase the sensitivity of molecular tools, the possibilities for multiplexing, as well as image resolution have recently been introduced; however, these methods have their pros and cons. Therefore, one needs to carefully consider the biological question of interest along with the nature of the sample before choosing the most suitable method or combination of methods. Herein, we review a few of the most exciting microscopy-based molecular techniques for proteomic analysis and cover the benefits as well as the disadvantages of their use.
Correction: Dupuy, E., et al. Comparison of XH2O Retrieved from GOSAT Short-Wavelength Infrared Spectra with Observations from the TCCON Network. Remote Sens. 2016, 8, 414
Authors: Dupuy Eric , Morino Isamu , Deutscher Nicholas , Yoshida Yukio , Uchino Osamu , Connor Brian , De Mazière Martine , Griffith David , Hase Frank , Heikkinen Pauli , Hillyard Patrick , Iraci Laura , Kawakami Shuji , Kivi Rigel , Matsunaga Tsuneo , Notholt Justus , Petri Christof , Podolske James , Pollard David , Rettinger Markus , Roehl Coleen , Sherlock Vanessa , Sussmann Ralf , Toon Geoffrey , Velazco Voltaire , Warneke Thorsten , Wennberg Paul , Wunch Debra , Yokota Tatsuya
Published: November 2016

n/a
The Modified SEBAL for Mapping Daily Spatial Evapotranspiration of South Korea Using Three Flux Towers and Terra MODIS Data
Authors: Lee Yonggwan , Kim Seongjoon
Published: November 2016

Evapotranspiration (ET) is expected to increase by a considerable amount because of the impact of future temperature increase. Nowadays, the daily to seasonal ET maps can be used to provide information for a sustainable and adaptive watershed eco-environment. This study attempts to estimate the spatial ET of South Korea (99,900 km2), located within the latitudes of 33°06′N to 43°01′N and the longitudes of 124°04′E to 131°05′E, on a daily basis. The satellite-based image-processing model Surface Energy Balance Algorithms for Land (SEBAL) was adopted and modified to generate the spatial ET data. The SEBAL was calibrated using two years (2012–2013) of measured ETs by an eddy covariance (EC) flux tower at three locations (two in a mixed forest area and one in a rice paddy area). The primary inputs for the model were land surface temperature/emissivity (LST/E), the Normalized Distribution Vegetation Index (NDVI), albedo (Ab) from a Terra Moderate-resolution Imaging Spectroradiometer (MODIS) satellite, a digital elevation model, and wind speed and solar radiation (Rs) from 76 ground-based weather stations. When LST data were unavailable because of clouds and/or snow, the bias-corrected ground temperature measured at the weather stations was used. The NDVI and Ab were used as the monthly average value to maintain relatively stable values rather than using the original time interval data. The determination coefficient (R2) between SEBAL and the flux tower ET was 0.45–0.54 for the two mixed forest towers and 0.79 for the rice paddy tower reflecting the known characteristics of closed and open space ET estimation. The spatial distribution of SEBAL showed that the spatial ET reflected the geographical characteristics, revealing that the ET of lowland areas was higher than that of highland areas.
Potential of Wake-Up Radio-Based MAC Protocols for Implantable Body Sensor Networks (IBSN)—A Survey
Authors: Karuppiah Ramachandran Vignesh , Ayele Eyuel , Meratnia Nirvana , Havinga Paul
Published: November 2016

With the advent of nano-technology, medical sensors and devices are becoming highly miniaturized. Consequently, the number of sensors and medical devices being implanted to accurately monitor and diagnose a disease is increasing. By measuring the symptoms and controlling a medical device as close as possible to the source, these implantable devices are able to save lives. A wireless link between medical sensors and implantable medical devices is essential in the case of closed-loop medical devices, in which symptoms of the diseases are monitored by sensors that are not placed in close proximity of the therapeutic device. Medium Access Control (MAC) is crucial to make it possible for several medical devices to communicate using a shared wireless medium in such a way that minimum delay, maximum throughput, and increased network life-time are guaranteed. To guarantee this Quality of Service (QoS), the MAC protocols control the main sources of limited resource wastage, namely the idle-listening, packet collisions, over-hearing, and packet loss. Traditional MAC protocols designed for body sensor networks are not directly applicable to Implantable Body Sensor Networks (IBSN) because of the dynamic nature of the radio channel within the human body and the strict QoS requirements of IBSN applications. Although numerous MAC protocols are available in the literature, the majority of them are designed for Body Sensor Network (BSN) and Wireless Sensor Network (WSN). To the best of our knowledge, there is so far no research paper that explores the impact of these MAC protocols specifically for IBSN. MAC protocols designed for implantable devices are still in their infancy and one of their most challenging objectives is to be ultra-low-power. One of the technological solutions to achieve this objective so is to integrate the concept of Wake-up radio (WuR) into the MAC design. In this survey, we present a taxonomy of MAC protocols based on their use of WuR technology and identify their bottlenecks to be used in IBSN applications. Furthermore, we present a number of open research challenges and requirements for designing an energy-efficient and reliable wireless communication protocol for IBSN.
Measurement of M2-Curve for Asymmetric Beams by Self-Referencing Interferometer Wavefront Sensor
Authors: Du Yongzhao
Published: November 2016

For asymmetric laser beams, the values of beam quality factor M x 2 and M y 2 are inconsistent if one selects a different coordinate system or measures beam quality with different experimental conditionals, even when analyzing the same beam. To overcome this non-uniqueness, a new beam quality characterization method named as M2-curve is developed. The M2-curve not only contains the beam quality factor M x 2 and M y 2 in the x-direction and y-direction, respectively; but also introduces a curve of M x α 2 versus rotation angle α of coordinate axis. Moreover, we also present a real-time measurement method to demonstrate beam propagation factor M2-curve with a modified self-referencing Mach-Zehnder interferometer based-wavefront sensor (henceforth SRI-WFS). The feasibility of the proposed method is demonstrated with the theoretical analysis and experiment in multimode beams. The experimental results showed that the proposed measurement method is simple, fast, and a single-shot measurement procedure without movable parts.
Optimal Resource Allocation Policies for Multi-User Backscatter Communication Systems
Authors: Lyu Bin , Yang Zhen , Gui Guan , Feng Youhong
Published: November 2016

This paper considers a backscatter communication (BackCom) system including a reader and N tags, where each tag receives excitation signals transmitted by the reader and concurrently backscatters information to the reader in time-division-multiple-access (TDMA) mode. In this system, we aim to maximize the total system goodput by jointly optimizing reader transmission power, time allocation, and reflection ratio for the cases of passive and semi-passive tags. For each case, an optimization problem is formulated, which is non-convex and can be solved by being decomposed into at most N feasible sub-problems based on the priority of allocated reader transmission power. First, for the passive tags case, by solving the convex sub-problems sequentially and comparing their maximum total goodput, we derive the optimal resource allocation policy. Then, for the semi-passive tags case, we find a close-to-optimal solution, since each sub-problem can be reformulated as a biconvex problem, which is solved by a proposed block coordinate descent (BCD)-based optimization algorithm. Finally, simulation results demonstrate the superiority of the proposed resource allocation policies.
MEMS IMU Error Mitigation Using Rotation Modulation Technique
Authors: Du Shuang , Sun Wei , Gao Yang
Published: November 2016

Micro-electro-mechanical-systems (MEMS) inertial measurement unit (IMU) outputs are corrupted by significant sensor errors. The navigation errors of a MEMS-based inertial navigation system will therefore accumulate very quickly over time. This requires aiding from other sensors such as Global Navigation Satellite Systems (GNSS). However, it will still remain a significant challenge in the presence of GNSS outages, which are typically in urban canopies. This paper proposed a rotary inertial navigation system (INS) to mitigate navigation errors caused by MEMS inertial sensor errors when external aiding information is not available. A rotary INS is an inertial navigator in which the IMU is installed on a rotation platform. Application of proper rotation schemes can effectively cancel and reduce sensor errors. A rotary INS has the potential to significantly increase the time period that INS can bridge GNSS outages and make MEMS IMU possible to maintain longer autonomous navigation performance when there is no external aiding. In this research, several IMU rotation schemes (rotation about X-, Y- and Z-axes) are analyzed to mitigate the navigation errors caused by MEMS IMU sensor errors. As the IMU rotation induces additional sensor errors, a calibration process is proposed to remove the induced errors. Tests are further conducted with two MEMS IMUs installed on a tri-axial rotation table to verify the error mitigation by IMU rotations.
A Pilot Study of Individual Muscle Force Prediction during Elbow Flexion and Extension in the Neurorehabilitation Field
Authors: Hou Jiateng , Sun Yingfei , Sun Lixin , Pan Bingyu , Huang Zhipei , Wu Jiankang , Zhang Zhiqiang
Published: November 2016

This paper proposes a neuromusculoskeletal (NMS) model to predict individual muscle force during elbow flexion and extension. Four male subjects were asked to do voluntary elbow flexion and extension. An inertial sensor and surface electromyography (sEMG) sensors were attached to subject's forearm. Joint angle calculated by fusion of acceleration and angular rate using an extended Kalman filter (EKF) and muscle activations obtained from the sEMG signals were taken as the inputs of the proposed NMS model to determine individual muscle force. The result shows that our NMS model can predict individual muscle force accurately, with the ability to reflect subject-specific joint dynamics and neural control solutions. Our method incorporates sEMG and motion data, making it possible to get a deeper understanding of neurological, physiological, and anatomical characteristics of human dynamic movement. We demonstrate the potential of the proposed NMS model for evaluating the function of upper limb movements in the field of neurorehabilitation.
Market Model for Resource Allocation in Emerging Sensor Networks with Reinforcement Learning
Authors: Zhang Yue , Song Bin , Zhang Ying , Du Xiaojiang , Guizani Mohsen
Published: November 2016

Emerging sensor networks (ESNs) are an inevitable trend with the development of the Internet of Things (IoT), and intend to connect almost every intelligent device. Therefore, it is critical to study resource allocation in such an environment, due to the concern of efficiency, especially when resources are limited. By viewing ESNs as multi-agent environments, we model them with an agent-based modelling (ABM) method and deal with resource allocation problems with market models, after describing users’ patterns. Reinforcement learning methods are introduced to estimate users’ patterns and verify the outcomes in our market models. Experimental results show the efficiency of our methods, which are also capable of guiding topology management.
The Dynamic Enterprise Network Composition Algorithm for Efficient Operation in Cloud Manufacturing
Authors: Ahn Gilseung , Park You-Jin , Hur Sun
Published: November 2016

As a service oriented and networked model, cloud manufacturing (CM) has been proposed recently for solving a variety of manufacturing problems, including diverse requirements from customers. In CM, on-demand manufacturing services are provided by a temporary production network composed of several enterprises participating within an enterprise network. In other words, the production network is the main agent of production and a subset of an enterprise network. Therefore, it is essential to compose the enterprise network in a way that can respond to demands properly. A properly-composed enterprise network means the network can handle demands that arrive at the CM, with minimal costs, such as network composition and operation costs, such as participation contract costs, system maintenance costs, and so forth. Due to trade-offs among costs (e.g., contract cost and opportunity cost of production), it is a non-trivial problem to find the optimal network enterprise composition. In addition, this includes probabilistic constraints, such as forecasted demand. In this paper, we propose an algorithm, named the dynamic enterprise network composition algorithm (DENCA), based on a genetic algorithm to solve the enterprise network composition problem. A numerical simulation result is provided to demonstrate the performance of the proposed algorithm.
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain
Authors: Li Zhonghua , Chen Fangzhou , Ye Shiyi , Guo Xiaozhen , Muhanmmad Memon Atta , Wu Meizhou , He Qigai
Published: November 2016

Porcine epidemic diarrhea virus (PEDV), a predominant cause of acute enteric infection, leads to severe dehydrating diarrhea and mortality in piglets all over the world. A virulent PEDV YN13 strain, isolated in our laboratory, was attenuated to yield an attenuated PEDV strain YN144. To better understand the pathogenesis mechanism and the virus-host interaction during infection with both PEDV YN13 and YN144 strains, a comparative proteomic analysis was carried out to investigate the proteomic changes produced in the primary target organ, using isobaric tags for relative and absolute quantitation (iTRAQ) labeling, followed by liquid chromatography tandem-mass spectrometry (LC-MS/MS). A total of 269 and 301 differently expressed proteins (DEPs) were identified in the jejunum tissues of the piglets inoculated with YN13 and YN144, respectively. Bioinformatics analysis revealed that these proteins were involved in stress responses, signal transduction, and the immune system. All of these involved interferon-stimulated genes (ISGs) which were up-regulated in jejunums by both of the PEDV-infected groups. Based on the comparative analysis, we proposed that different changes induced by YN13 and YN144 in heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), eukaryotic initiation factor 4G1 (eIF4G1), and some members in the heat shock protein (HSP) family, may be responsible for differences in their pathogenicity.
Assessment of FAO AquaCrop Model for Simulating Maize Growth and Productivity under Deficit Irrigation in a Tropical Environment
Authors: Greaves Geneille , Wang Yu-Min
Published: November 2016

Crop simulation models have a pivotal role to play in evaluating irrigation management strategies for improving agricultural water use. The objective of this study was to test and validate the AquaCrop model for maize under deficit irrigation management. Field observations from three experiments consisting of four treatments were used to evaluate model performance in simulating canopy cover (CC), biomass (B), yield (Y), crop evapotranspiration (ETc), and water use efficiency (WUE). Statistics for root mean square error, model efficiency (E), and index of agreement for B and CC suggest that the model prediction is good under non-stressed and moderate stress environments. Prediction of final B and Y under these conditions was acceptable, as indicated by the high coefficient of determination and deviations <10%. In severely stressed conditions, low E and deviations >11% for B and 9% for Y indicate a reduction in the model reliability. Simulated ETc and WUE deviation from observed values were within the range of 9.5% to 22.2% and 6.0% to 32.2%, respectively, suggesting that AquaCrop prediction of these variables is fair, becoming unsatisfactory as plant water stress intensifies. AquaCrop can be reliably used for evaluating the effectiveness of proposed irrigation management strategies for maize; however, the limitations should be kept in mind when interpreting the results in severely stressed conditions.
Une sous-espèce française de Chelidura pyrenaica (Bonelli) (Dermaptères) : C. pyrenaica arverna, ssp. n
Authors: David Jean , Van Herrewege Christian
Published: November 2016

In the «Massif Central » of France (Mont Mézenc) the earwig Chelidura pyrenaica is represented by a population characterized by the shape of the male cerci, more robust and less arcuate. This population corresponds to a well defined sub-species which is named ssp. arverna. This subspecies was compared to the nominal one by a biometrical analysis which resulted in the definition of the best criteria of discrimination.
Un odonate des eaux temporaires : Hemianax ephippiger (Burm.)
Authors: Degrange Charles
Published: November 2016

Hemianax ephippiger, Odonate à répartition afro-asiatique et à migrations spectaculaires a été récemment capturé à l'état larvaire dans le Midi de la France. Une tentative d'acclimatation a été observée dans une mare artificielle aux environs de Grenoble. L'échec de cette extension de l'aire de répartition serait dû à la prédation exercée par les Hémiptères Notonectidae. Par ailleurs l'observation semble montrer que H. ephippiger coloniserait de préférence les milieux aquatiques temporaires.
La spéciation sympatrique et allopatrique chez les Lépidoptères
Authors: Niculescu V.
Published: November 2016

The alloparic and sympatric spéciations were illustrated in some Lepidoptera. This study resulted in the discussion of some hypothesis on the evolution of the species.
Contribution à l'étude des Blattaria de la Faune Malgache. II. Description de huit espèces nouvelles appartenant aux genres Gromphadorhina Brunner v.W. et Elliptorhina gen. nov
Authors: Van Herrewege Christian
Published: November 2016

Après examen des espèces de blattes malgaches endémiques, précédemment incluses dans le genre Gromphadorhina, il est apparu que celles-ci appartenaient en fait à deux genres : Gromphadorhina s.s et Elliptorhina, gen. nov. Les deux genres peuvent être facilement distingués selon quatre critères : 1. -contours généraux du pronotum ; 2. -forme de l'excavation notale ; 3. -forme et position des tubercules du pronotum ; 4. -présence ou absence d'une carène transverse meso-faciale.

3 espèces nouvelles (oblongonota , picea et maxima ) ont été décrites dans Gromphadorhina Brunner v.W. et viennent s'ajouter à celles connues précédemment (portentosa et grandidieri).

5 espèces nouvelles (oblonga , lefeuvri, davidi, testacea et problematica) ont été décrites dans Elliptorhina et viennent s'ajouter à cinq autres décrites anté¬ rieurement dans le genre Gromphadorhina (laevigata javanica, coquereliana, chopardi et brunneri).

L'habitus, les vues latérales et perpendiculaires du pronotum ont été figurés pour chacun des sexes, lorsqu'ils sont connus. Des dessins des génitalia mâles ont été donnés pour illustrer la tribu des Gromphadorhinini dont une clé de détermination des genres a été élaborée.
Cryptococcus hungaricus var. gallicus, nouvelle variété de levure rencontrée chez deux cerfs Axis — Axis axis (Erxleben)
Authors: Saëz Henri
Published: November 2016

Description d'une nouvelle variété de levure, Cryptococcus hungaricus var. gallicus. Deux souches ont été isolées dans la cavité buccale de deux Cerfs axis — Axis axis (Erxleben) — morts au Parc Zoologique de Paris. La souche A 2979, rencontrée chez un sujet mâle, né en captivité et mort moins de vingt-quatre heures après la naissance, est la souche-type.
Lactarius aspideus (Fries), espèce inconnue des mycologues français
Authors: Grospelier L.
Published: November 2016

Deux Lactaires (Basidiomycètes) proches mais spécifiquement bien distincts, Lactarius aspideus Fr. et L. flavidus Boudier, sont étudiés et décrits en parallèle.
Une station d'Araujia sericifera (Brotero) = Physiantus albens (Martius) en voie de naturalisation aux environs d'Elne (Pyrénées-Orientales)
Authors: Mignot Pierre
Published: November 2016

Cette information comporte une courte description de l'espèce, un aperçu historique d'auteurs l'ayant signalée et quelques indications géographiques sur une zone où la plante se répand.
Contribution à l'étude de Tyromyces fumidiceps (Aphyllophorales, Polyporaceae)
Authors: David Alice
Published: November 2016

De nombreuses récoltes françaises de Tyromyces fumidiceps Atk. ont permis d'approfondir la connaissance de cette espèce et d'affirmer qu'elle trouve bien sa place dans le genre Tyromyces sensu stricto à côté de T. chioneus et T. kmetii. Ces trois espèces ont en commun de très nombreux caractères : pourriture blanche, même type d'hyphes génératrices dans le carpophore et un mycélium en culture tout à fait identique avec incrustations de type skeletocutis et chlamydospores. T. fumidiceps est tétrapolaire et présente un comportement nucléaire hétérocytique.
Présence de Zygaena brizae vesubiana Le Charles dans l'Isère et dans la Drôme (Lepid., Zygaenidae)
Authors: Drouet Eric , Manzoni Gérard
Published: November 2016

The presence of Zygaena brizae vesubiana is recorded for the first time from the district (département) of Isère (France). Other new localities, on the northern limit of the repartition of this species previously known, are given and noted on a map. Some ethological aspects are described.
Description de neuf Laboulbéniales (Ascomycètes) d'Amérique tropicale
Authors: Balazuc Jean
Published: November 2016

Description de Rhachomyces calypso (d'Amazonie, parasite d'un Coléoptère Carabique), de Laboulbenia arnaudii (de Guyane française, parasite d'un Coléoptère Ténébrionide), de L. b ordonii (du Vénézuela et de Guyane, parasite de Coléoptères Carabiques), de L. durantonii (de Guyane, sur Coléoptère Chrysomélide), de L. jovetae (de Guyane, sur Coléoptère Carabique), de L. orghidanii (du Vénézuela, sur Coléoptère Carabique), de L. remex et L. rucujenna (de Guyane, sur Coléoptères Carabiques), et de Stigmatomyces matilei (du Mexique, sur un Diptère Muscide).
Introduction pratique à la systématique des organismes des eaux continentales françaises. - 7 : Planipennes, Mégaloptères et Lépidoptères à larves aquatiques
Authors: Dethier Michel , Haenni Jean-Paul
Published: November 2016

Des clés illustrées permettent la détermination des genres et de certaines espèces des Planipennes, Mégaloptères et Lépidoptères à larves aquatiques vivant en France et dans les régions voisines. Les principales caractéristiques morphologiques et biologiques de ces insectes sont fournies et on trouvera dans la bibliographie les références des principales faunes et articles les concernant.
Le gisement paléontologique et préhistorique de la rivière souterraine de Padirac (affluent R. de Joly), commune de Miers (Lot, France) : principaux résultats de l'expédition «Padirac 1985»
Authors: Philippe Michel , Jaubert Jacques , Rouzaud François
Published: November 2016

In 1983, an important paleontological and prehistoric site was discovered in the karst system of Padirac (Lot, France). This paper gives the main consequences of the second scientific expedition in this cave (10 days running underground). The fauna is various and numerous. It seems to indicate a rissian age but the radiocarbon results do not correspond to this hypothesis, perhaps because of the addition of more recent bones. Stone tools give evidence of a Mousterian of the Acheulian Tradition.

The genesis of the deposit is explained by the carriage of bones and prehistoric stones in the course of the successive risings of the underground river.
Une espèce nouvelle de Gecko Eublepharis ensafi (Sauria, Gekkonidae, Eublepharinae) du Khouzistan (sud-ouest de l'Iran)
Authors: Baloutch M. , Thireau Michel
Published: November 2016

Eublepharis ensafi nov. sp. is named on the basis of one specimen from Fakke, a locality about 150 km to north of Ahvaz (Iran). This specimen is probably the largest gecko known today. In various morphological characteristic, E. ensafi clearly differ of the other species known in Iran : E. macularius and E. angramainyu.
Note sur Commelina communis L. (Commelinales Commelinaceae)
Authors: Forestier Christian
Published: November 2016

L'auteur donne un résumé des renseignements acquis sur cette espèce ainsi que d'observations personnelles notamment sur l'influence présumée de la température concernant l'ouverture et la fermeture des fleurs, leur taille, le nombre des graines et sa dissémination à Lyon et sa région.
Mortalité et stock de l'amphipode Niphargus virei dans le système karstique de Drom
Authors: Turquin Marie-José
Published: November 2016

Après avoir établi la loi de croissance de l'amphipode souterrain Niphargus virei on peut transformer les histogrammes des tailles annuels (obtenus par filtration d'un exutoire en temps de crue) en pyramides des âges. Dès lors, en utilisant la théorie de pêches mise au point par les biologistes marins, on peut évaluer la mortalité naturelle et la mortalité due à la dérive. L'abondance de cette population fluctue en fonction des conditions climatiques.
Etude biométrique de deux populations de mulot, genre Apodemus (Rodentia, Muridae), du Bas-Dauphiné (Sud-Est de la France)
Authors: Brunet-Lecomte Patrick
Published: November 2016

The purpose of this study is the biometrical discrimination of two populations of field mouse, genus Apodemus, from South France. The first population characterized by the absence of a collar under the neck could belong to the species A. sylvaticus, and the second population characterized by a collar under the neck could belong to the species A. flavicollis. For each individual of two populations three corporal measures and two dental measures are taken. Five discriminant functions are calculated. The functions show that dental measures are better than corporal measures for discriminating populations.
Note sur les Hyménoptères Tenthrédoïdes (XII). - 26. Tenthrèdes rares ou nouvelles pour la France
Authors: Chevin Henri
Published: November 2016

L'auteur signale la capture de 47 espèces rares dont 3 espèces nouvelles pour la France : Pamphilius fumipennis (Curtis), Macrophya erythrogastra (Spinola), Pristiphora pseudocoactula (Lindqvist).
Description de deux hybrides nouveaux découverts dans les Pyrénées centrales
Authors: Aubin Pierre
Published: November 2016

Description de Saxifraga prudhommei (S. intricata Lap. x S. granulata L.) et Carex cariei (C. panicea L. x C. pallescens L.).
Knautia lebrunii J. Prudhomme et les errances de Knautia salvadoris Sennen ex Szabo
Authors: Prudhomme Jean
Published: November 2016

Knautia salvadoris Sennen ex Szabo est un taxon proche de K. arver-nensis (Briq.) Szabo appartenant à la subsect. Purpurascentes. K. salvadoris in Flora Europaea ne correspond pas à ce taxon et représente une espèce méconnue appartenant à la subsect. Silvaticae que nous nommerons Knautia lebrunii J. Prudhomme. L'aire de Knautia lebrunii semble limitée aux confins de la Cerdagne et de la haute vallée de la Têt.
Comptes rendus d'herborisation dans la chaîne des Pyrénées françaises
Authors: Dutartre Gilles
Published: November 2016

Au cours des étés de 1981, 1983 et 1985, nos herborisations dans les Pyrénées Orientales, Centrales et Occidentales nous on permis de repérer quelques localités intéressantes ou nouvelles ; nous croyons utile de signaler ici celles qui concernent des plantes réputées rares en dressant la liste des espèces rencontrées pendant nos trois séjours dans la chaîne pyrénéenne.
Etude biométrique et répartition de Sorex coronatus et Sorex granarius (Mammalia, Insectivora) dans le nord-ouest de l'Espagne
Authors: Brunet-Lecomte Patrick , Delibes Miguel
Published: November 2016

Deux espèces de Sorex du groupe araneus, S. coronatus et S. granarius sont présentes dans le Nord-Ouest de l'Espagne. Du fait de leur ressemblance morphologique, elles sont difficilement différenciables et par conséquent leur répartition respective est encore mal connue. La présente étude propose une méthode statistique pour identifier les individus les plus caractéristiques des espèces, et apporte de nouvelles précisions sur leur répartition dans le Nord-Ouest de l'Espagne.
L'école entomologique lyonnaise du XIXe siècle
Authors: Clary Joël , Allemand Roland , Richoux Philippe
Published: November 2016

Au cours du XIXe siècle, l'Entomologie a connu un essor considérable en Europe. A Lyon, sous l'égide de E. Donzel, A. Foudras, B.-P. Perroud, E. Mulsant, C. Rey et de quelques autres, des études entomologiques se sont développées et ont peu à peu acquis une notoriété internationale. La présence de ces spécialistes, l'abondance de leurs publications et le matériel de référence accumulé permettent de définir une Ecole entomologique qui a suscité de nombreuses vocations. Les travaux de ces entomologistes ont été diffusés par les sociétés savantes de l'époque, en particulier par la Société linnéenne de Lyon qui a assuré en partie la publication de «l'Histoire Naturelle des Coléoptères de France» de Mulsant et Rey. Des collections renfermant de nombreux types sont conservées à Lyon et des renseignements sont donnés sur les lieux actuels de conservation.
Sélection trophique chez les Cassidinae (Coleoptera Chrysomelidae)
Authors: Jolivet Pierre
Published: November 2016

Les Cassidinae représentent la dernière sous-famille des Chrysomelidae et forment avec les Hispinae la 5e section des Cryptostoma. Les Cassidinae ont été cités de 29 familles de Dicotylédones et des Palmae (Monocotylédones). La sélection la plus commune est la famille des Convolvulacées dont semblent avoir dérivé toutes les autres, excepté les Palmae.
Variabilité et biologie de Dorcadion (Pedestrodorcadion) arenarium subsp. subcarinatum (Col. Cerambycidae) en Savoie
Authors: Keith Denis
Published: November 2016

L'éthologie de Dorcadion (Pedestrodorcadion ) arenarium subsp. sub-corinatum Miiller est présentée dans les biotopes savoyards. Les variétés de coloration connues (sabandum Pic, subsabaudum Breuning) sont rapportées à un simple dimorphisms sexuel et sont mises en synonymie avec la subsp. subcarinatum.
MicroRNA-181b Inhibits Cellular Proliferation and Invasion of Glioma Cells via Targeting Sal-Like Protein 4
Authors: Zhou Yu , Peng Yong , Liu Min , Jiang Yugang
Published: November 2016

MicroRNAs (miRs), a class of noncoding RNAs that are 18‐25 nucleotides in length, are able to suppress gene expression by targeting complementary regions of mRNAs and inhibiting protein translation. Recently, miR-181b was found to play a suppressive role in glioma, but the regulatory
mechanism of miR-181b in the malignant phenotypes of glioma cells remains largely unclear. In this study, we found that miR-181b was significantly downregulated in glioma tissues when compared with normal brain tissues, and decreased miR-181b levels were significantly associated with high-grade
pathology and a poor prognosis for patients with glioma. Moreover, miR-181b was downregulated in glioma cell lines (U87, SHG44, U373, and U251) compared to normal astrocytes. Overexpression of miR-181b significantly decreased the proliferation, migration, and invasion of glioma U251 cells.
Sal-like protein 4 (SALL4) was identified as a novel target gene of miR-181b in U251 cells. The expression of SALL4 was significantly upregulated in glioma tissues and cell lines, and an inverse correlation was observed between the miR-181b and SALL4 expression levels in glioma. Further investigation
showed that the protein expression of SALL4 was negatively regulated by miR-181b in U251 cells. Knockdown of SALL4 significantly inhibited the proliferation, migration, and invasion of U251 cells, while overexpression of SALL4 effectively reversed the suppressive effects of miR-181b on these
malignant phenotypes of U251 cells. In conclusion, our study demonstrates that miR-181b has a suppressive effect on the malignant phenotypes of glioma cells, at least partly, by directly targeting SALL4. Therefore, the miR-181b/SALL4 axis may become a potential therapeutic target for glioma.
Overexpression of Protease Serine 8 Inhibits Glioma Cell Proliferation, Migration, and Invasion via Suppressing the Akt/mTOR Signaling Pathway
Authors: Yang Hu-yin , Fang Da-zhao , Ding Lian-shu , Hui Xiao-bo , Liu Dai
Published: November 2016

Protease serine 8 (PRSS8), a serine peptidase, has a widespread expression in normal epidermal cells. Recently, many researchers demonstrated downregulation of PRSS8 in cancer tissues as well as its tumor suppressor role in cancer development. However, the biological functions of PRSS8
in glioma remain unclear. In the current study, we demonstrated a decreased expression of PRSS8 in glioma tissues and cell lines. PRSS8 upregulation inhibited glioma cell proliferation, migration, and invasion. In addition, xenograft experiments showed that PRSS8 overexpression suppressed
glioma cell growth in vivo. We also found that upregulated PRSS8 reduced the protein expression levels of p-Akt and p-mTOR in glioma cells. Taken together, our study demonstrated that overexpression of PRSS8 inhibited glioma cell proliferation, migration, and invasion via suppressing the Akt/mTOR
signaling pathway. Therefore, PRSS8 may act as a novel therapeutic target for glioma.
Methods for Assessing the Adherence to Medical Devices
Authors: Johnson Leah , Swarner Stephanie , van der Straten Ariane , Rothrock Ginger
Published: November 2016

The assessment of patient adherence to medication is necessary to distinguish between nonadherence and inferior drug efficacy, which is crucial for avoiding poor clinical outcomes. Adherence measurements pose various challenges, as many methods rely on subjective assessments or slow and costly measurements, which are infeasible in resource-poor settings. Recent developments of new medical devices for delivery of medications requires additional considerations in terms of adherence. In this report, we propose that medical devices may serve a dual-functional purpose: deliver drug and monitor adherence. We provide an illustrative case study that involves assessing the adherence of vaginal rings for delivery of antiretroviral drugs for pre-exposure prophylaxis (PrEP) of HIV.
OBSERVATIONS AND SIMULATIONS OF THE Na i D1 LINE PROFILES IN AN M-CLASS SOLAR FLARE
Authors: Kuridze D. , Mathioudakis M. , Christian D. J. , Kowalski A. F. , Jess D. B. , Grant S. D. T. , Kawate T. , Simões P. J. A. , Allred J. C. , Keenan F. P.
Published: November 2016

We study the temporal evolution of the Na i D1 line profiles in the M3.9 flare SOL2014-06-11T21:03 UT, using observations at high spectral resolution obtained with the Interferometric Bidimensional Spectrometer instrument on the Dunn Solar Telescope combined with radiative hydrodynamic simulations. Our results show a significant increase in the intensities of the line core and wings during the flare. The analysis of the line profiles from the flare ribbons reveals that the Na i D1 line has a central reversal with excess emission in the blue wing (blue asymmetry). We combine RADYN and RH simulations to synthesize Na i D1 line profiles of the flaring atmosphere and find good agreement with the observations. Heating with a beam of electrons modifies the radiation field in the flaring atmosphere and excites electrons from the ground state 3s 2S to the first excited state 3p 2P, which in turn modifies the relative population of the two states. The change in temperature and the population density of the energy states make the sodium line profile revert from absorption into emission. Furthermore, the rapid changes in temperature break the pressure balance between the different layers of the lower atmosphere, generating upflow/downflow patterns. Analysis of the simulated spectra reveals that the asymmetries of the Na i D1 flare profile are produced by the velocity gradients in the lower solar atmosphere.
TRANSVERSE VELOCITY SHIFTS IN PROTOSTELLAR JETS: ROTATION OR VELOCITY ASYMMETRIES?
Authors: De Colle Fabio , Cerqueira Adriano H. , Riera Angels
Published: November 2016

Observations of several protostellar jets show systematic differences in radial velocity transverse to the jet propagation direction that have been interpreted as evidence of rotation in the jets. In this paper we discuss the origin of these velocity shifts, and show that they could originate from rotation in the flow, or from side-to-side asymmetries in the shock velocity, which could be due to asymmetries in the jet ejection velocity/density or in the ambient medium. For typical poloidal jet velocities (∼100–200 km s−1), an asymmetry ≳10% can produce velocity shifts comparable to those observed. We also present three-dimensional numerical simulations of rotating, precessing, and asymmetric jets, and show that, even though for a given jet there is a clear degeneracy between these effects, a statistical analysis of jets with different inclination angles can help to distinguish between the alternative origins of transverse velocity shifts (TVSs). Our analysis indicates that side-to-side velocitiy asymmetries could represent an important contribution to TVSs, being the most important contributor for large jet inclination angles (with respect the the plane of the sky), and cannot be neglected when interpreting the observations.