bluuebunny/crossref_metadata_2025 huggingface dataset:
Uma explicação alternativa, espírita e científica, para a concepção do corpo material de Jesus em Maria ainda virgem
Authors: da Fonseca Alexandre
Published: June 2022

A questão sobre a concepção do corpo de Jesus por Maria ainda virgem divide opiniões no meio espírita. Enquanto boa parte dos espíritas acredita que Jesus foi concebido de modo natural, isto é, através de relação sexual entre Maria e José, outros consideram que Jesus tenha sido um agênere, isto é, tenha tido um corpo fluidicamente tornado visível e tangível. Nesse último caso, Jesus não teria tido um corpo físico como todos os encarnados. A questão parece ter despertado o interesse de Kardec pois ele menciona em A Gênese que iria tratar posteriormente do assunto chamando-o de “mistério da encarnação”. Em função de sua desencarnação, não foi possível saber o que ele pensava a respeito. Neste artigo, apresento uma solução alternativa e cientificamente fundamentada para o “mistério da encarnação” de um Espírito através de uma mulher virgem, isto é, que não tenha tido relações sexuais ou não tenha passado por inseminação artificial. Essa solução é apresentada com base em conceitos sólidos da Ciência e do Espiritismo, e demonstra a possibilidade, ainda que apenas teórica, de um ser humano de “carne e osso” ser concebido no ventre de uma mulher virgem. Conceitos do processo de fecundação da Biologia e dos fenômenos de materialização do Espiritismo são utilizados na composição da solução aqui apresentada. Não se defende que essa solução seja definitiva pois não há como demonstrar cientificamente a verdade factual sobre a concepção de Jesus. Porém, além de mostrar a excelência da Doutrina Espírita como teoria científica e filosófica capaz de explicar a possibilidade de fenômenos tão complexos como esse, o presente estudo mostra que a teoria do corpo fluídico de Jesus não é mais a única a explicar a concepção e nascimento de Jesus pela virgem Maria. Dizendo de outra maneira, e talvez mais importante, essa alternativa, ainda que teórica, reforça e sustenta o corpo material de Jesus independentemente de Maria tê-lo concebido virgem ou não.
Interaction of multiple jets in bubble electrospinning
Authors: Liu Hong-Yan , Yao Yan-Ju , Qian Man-Yu
Published: June 2022

The bubble electrospinningis a peerless technology for mass-production of
various functional nanofibers. During the spinning process, multiple jets
are ejected, which might be interacted with each other. The interaction
might result in mass transfer, energy transfer and force in balance, all
these factors will greatly affect the mechanical property and morphology of
the resultant fibers. A theoretical model is established to study the
two-jets combination during the spinning process, the mass conservation and
momentum conservationare considered, and the combined fiber?s diameter and
moving velocity are theoretically elucidated. The present theory analysis
can be easily extended to multile jets interation.
Energy-saving optimization control method of commercial building double cold source air-conditioning units
Authors: Wang Yan , Zhang Xiaohui , Meng Yanhua , Wang Xianyi
Published: June 2022

In order to improve the energy-saving level of commercial buildings? air-conditioning units with double cold sources and reduce the energy cost, an energy-saving optimal control method of commercial buildings? air-conditioning units with double cold sources based on self-organizing neural network is proposed. Constrained parameter model of energy-saving control of commercial buildings? double-cold-source air-conditioning units is constructed. Taking the balanced real-time dynamic adjustment characteristic quantity of inverter of commercial buildings? double-cold-source air-conditioning units as the control object, combined with the fuzzy constraint method of variable frequency speed adjustment parameters and stroke adjustment power of commercial buildings? double-cold-source air-conditioning units, the steady-state adjustment of energy-saving output of commercial buildings? double-cold-source air-conditioning units is realized, and the self-organizing neural network control model of periodic potential energy load of building HVAC system is established. Combined with the small disturbance suppression method of motor rated power, the optimal control design of energy-saving of commercial buildings. The simulation results show that the output stability of the energy-saving control of commercial building air-conditioning units with double cold sources is good, the steady-state working ability is strong, and the energy-saving effect of commercial building air-conditioning units with double cold sources is good.
New concept of in/out air quality control in livestock buildings
Authors: Ivanisevic Mladen , Zoranovic Miodrag , Topisirovic Goran , Jugovic Milan , Rajs Vladimir , Vejnovic Srdjan , Keselj Krstan
Published: June 2022

The object of this research is the new concept of the original universal system for air quality and energy control in laboratory conditions (wet scrubbing system) based on the ?clean air in/out? principle. Namely, the process involves a partial or complete exchange of recirculated treated air. From the aspect of water, as a pure medium, the system is characterized by broad application in the open, semi-open, and closed air treatment systems: primarily in the breeding and accompanying agricultural facilities, industrial, cultural, sports, tourist, medical and other controlled spaces. The analysis showed that the system at its inlet unit and with the block structure and logical phase development, proved energy, environ-mental and qualitative efficiency in the removal of PM10 and PM2.5 particles from the controlled dust doses in laboratory air. The measurements of PM10 and PM2.5 concentrations were performed with two Alphasense OPC-N3 optical counters at the inlet and outlet of the system. Five operating regimes with frequency regulated number of revolutions of the turbo elements that was taken as an independent variable, achieved different degrees of removal of PM10 and PM2.5 from the treated laboratory air: 97.70-98.53% and 62.19-75.75%, respectively. The assessment of system energy use was done by parallel measuring of electric power and comparative deviations of its absolute values in the first decimal. Energy consumption for the treatment of 1m3 of air ranged from 0.00011- 0.00016 kWm?3. Statistical analysis of qualitative indicators revealed significant differences between the operating regimes and the obtained values.
Stability of fiducial cephalometric landmarks of growing Class II malocclusion patients: a three-dimensional retrospective study
Authors: Santana Lucas Garcia , Cheib Paula Loureiro , de Pársia Henrique Gontijo , Franchi Lorenzo , Moro Alexandre , Souki Bernardo Q.
Published: June 2022

Objectives

To evaluate three-dimensionally (3D) the stability of Nasion (Na), Sella (S), Basion (Ba), Porion (Po), and Orbitale (Or) in different age groups of growing Class II malocclusion patients and, additionally, to assess rotational changes of the S-Na and Ba-Na lines and the Frankfurt Horizontal Plane (FHP).

Materials and Methods

Cone-beam computed tomography studies of 67 Class II division 1 malocclusion patients, acquired at baseline (T0) and 1 year later (T1), were retrospectively assessed. Anterior cranial fossa was used for volumetric superimposition. Subjects were grouped according to their age at T0: group 1 (G1) (8–10 years), G2 (11–13 years), and G3 (14–17 years). Quantitative assessments of the 3D linear displacements (Euclidean distance) in the position of Na, S, Ba, Po, and Or were performed. Displacement in the X, Y, and Z projections and the rotation of S-Na, Na-Ba, and FHP were also quantified.

Results

All cephalometric landmarks showed 3D displacement (P = .001) in the three age groups. Orbitale remained stable in the vertical and sagittal dimension from 8 to 17 years (P > .05). S-Na, Na-Ba, and the FHP showed statistically significant angular rotation (P < .05) in younger patients (G1), while in older individuals (G2 and G3) they were stable (P > .05).

Conclusions

Na, S, Ba, and Po showed vertical and sagittal positional changes relative to the anterior cranial fossa during the growth of Class II individuals. After age 11, S-Na, Na-Ba, and FHP did not show rotation and, thus, are valid parameters for angular cephalometric analysis in Class II growing patients.
Pulmonary Function and Aerobic Capacity Responses to Equine Assisted Therapy in Adolescents with Idiopathic Scoliosis: A Randomized Controlled Trial
Authors: Abdel Ghafar Mohamed A. , Abdelraouf Osama R. , Abdel-aziem Amr A. , Elnegamy Tamer E. , Mohamed Mariam E. , Yehia Amr M. , Mousa Gihan Samir
Published: June 2022

Background: Idiopathic scoliosis is a common spinal malalignment that negatively impacts the respiratory system and physical conditioning in adolescents. Equine-assisted therapy comprises therapeutic horseback riding that optimizes physical performance and mobility in a range of contexts. However, the influence of equine-assisted therapy on pulmonary function remains unclear.Objective: To examine the impact of 10 weeks of hippotherapy combined with Schroth exercises on pulmonary function and aerobic capacity in adolescents with idiopathic scoliosis.Methods: A randomized controlled trial including 45 patients, randomly assigned to experimental and control groups, was performed. Patients in the experimental group received 15 30-min sessions of hippotherapy over a period of 10 weeks. The 2 groups attended a 60-min session of Schroth exercises 3 times/week for 10 weeks. Pulmonary function and functional capacity were assessed before and after the intervention.Results: Pre- and post-intervention variables (FVC, FEV1, FEV1/FVC, MVV and 6MWT) revealed significant improvement in both groups (p < 0.05). The improvement in the experimental group was significantly higher than in the control group (p < 0.05).Conclusion: The addition of hippotherapy to Schroth exercises resulted in improved pulmonary function and aerobic capacity in adolescents with idiopathic scoliosis.
LAY ABSTRACTScoliosis is a 3-dimensional spine deformation disorder that has direct consequences on the thoracic cage, resulting in lung constriction and functional difficulties in adolescents. Conservative therapy approaches are mostly designed to correct the spinal bony curvature rather than address adverse negative deterioration. This study investigated the effect of hippotherapy (equine therapy) in combination with Schroth exercises on pulmonary function and aerobic capacity in adolescents with idiopathic scoliosis. The combination of hippotherapy with Schroth exercises had a significant benefit compared with Schroth exercises alone. Horseback riding therapy could be an innovative complementary physical therapy technique for improving respiratory and physical functioning in adolescents with idiopathic scoliosis.
Residential Mortgage Portfolio, Product Innovation and Performance of Commercial Banks in Kenya
Authors: Nyang'iye Samson Akumu , Iraya Cyrus , Ochieng Duncan Elly
Published: June 2022

This study sought to investigate the relationship between residential mortgage portfolios, product innovation, and performance of commercial banks in Kenya. The study was anchored on the Modern Portfolio Theory, Agency Theory, and Asymmetric Information Theory. The study adopted a correlational descriptive research design and data collected from the annual residential mortgage surveys conducted by the central bank of Kenya (CBK) on commercial banks covering a 13-year period from 2006 to 2018. Further, the financial statements of commercial banks and Kenya Bankers Association database were used as a source of secondary data. Data were analyzed via panel data approaches. The Baron and Kenny (1986) approach was used to test the hypothesis. The results revealed that residential mortgage portfolio attributes, namely: portfolio quality and mortgage interest return significantly influence bank performance. The effect of mortgage terms on the relationship between mortgage portfolio quality and performance was negative and statistically significant. Loan to value (LTV) ratio was however found not to significantly intervene in the relationship between residential mortgage portfolios and the performance of banks operating in Kenya. From the findings, the study suggested that bank managers pay attention to the institutional environment and product characteristics in designing their mortgage loan portfolios.
Contamination by NOx type Pollutants in the Leach Ate from the Andralanitra Garbage Dump (Antananarivo Madagascar)
Authors: Rajaona Andrianaivoravelona Rafihavanana , Ravelonandro Pierre Hervé , Tantely Mitantsoa Julie , Andrianony Fara Arimalala
Published: June 2022

The study concerns the analysis of physic-chemical parameters in order to establish the state of pollution of a garbage dump site. The interpretation of the data is done by standardized principal component analysis. Thus, leachate samples were taken at 9 study stations in wet and dry periods. The results show that among the parameters studied, there is a high content of BOD5 (592,035 mg/L), EC (16,786 mS/cm) and COD (1373,684 mg/L). The concentration level of nitrates and nitrites greatly exceeds the norm; for the old landfill, the NO2- contents vary from 191,527 mg/L to 875,206 mg/L and the NO3- ranging from 384,926 mg/L to 1584,021 mg/L, we thus observe the influence of humidity on the concentrations of physic-chemical parameters. Furthermore, the chemical composition and mass concentrations of pollutants at the sites are highly dependent on the nature of the waste and the degree of pollution differs from one site to another. The considerable increase in the content of these pollutants is favored by bacterial activities during the transformation of the organic matter present in the leachate. However, the importance of the degree of contamination of the landfill favoring the pollution of the receiving environment is confirmed.
Grain Size Distribution of the Sediments from Odi River, Bayelsa State, Nigeria
Authors: Akpofure Edirin , Eteh Desmond
Published: June 2022

Ten samples from Odi River bed were collected by divers at different locations and sent to the laboratory for granulometric analysis. Samples were dried to remove moisture content and poured into a set of BSS standard sieves and mechanically vibrated for at least fifteen minutes to enable the grains to separate into their different sizes. Textural and statistical parameters were then calculated from the results of the particle size distribution. The result shows that the grain size ranges from -2 φ – -1 φ (granules) to 3 φ – 4 φ (very fine sand). The average mean of the population is 0.89 φ, with a modal class in the 1 φ – 2 φ size grade. The average sorting value is 1.26 σ which indicates a poorly sorted population. Skewness varies through the population, but, the average skewness is -0.16 (Negatively skewed). 60% of the sediments range from leptokurtic to extremely leptokurtic, 10% are very platykurtic, 10% are platykurtic and 20% are mesokurtic. Traction and saltation transport modes were inferred from the cumulative curves of the sediments. The plot of skewness versus kurtosis shows the energy of deposition to be fluctuating between high and low, depositing coarse and fine sands facies respectively. The grain size distribution is observed to be finer downstream.
Long-Term Social Effects of Colonisation on the Culture of the Colonised
Authors: Kouega Jean-Paul
Published: June 2022

The study set out to check what has become, years after decolonisation, of the long-term social features that were introduced at gun point into the culture of the colonised during the colonisation years. The data were collected via a 26- item questionnaire that focused on key cultural elements including food, body modification, dressing, language, religion, marriage, and naming. A total of 300 informants were contacted of which 110 were male and 190 were females, with 170 educated in French and 130 in French. They were students majoring in English on the one hand, and science-oriented students specialising in mechanical, electrical, computer, insurance, and banking engineering and learning business English on the other hand. The analysis revealed that, for each cultural token tested, there was a tendency for the colonised to mimic the coloniser. Imported meals were eaten regularly, body lotions were produced by the coloniser, the wigs they wore were made with the coloniser’s natural hair, clothes thrown away by the coloniser were bought, the coloniser’s language was widespread, artificial nails resembling the coloniser’s were gummed on the colonised fingers, the faith of the coloniser was adopted by some people, emphasis was put on church marriage by some people, polygamy was rejected by some people following the injunctions of their pastors, and names were taken from a repertoire drawn up by the coloniser. In short, several years after decolonisation, the social cultural features that the coloniser imposed at gun point on the colonised parents were joyfully adopted by the colonised, to the point that the latter spends huge sums of money to acquire these features that make him or her look like the coloniser.
Holden Caulfield – A Faux Rebel?
Authors: Zbircea Raluca
Published: June 2022

Through analysis of the importance of education in the novel Catcher in the Rye, the scope of this paper is to explore how genes and the environment come together in shaping a child's behaviour.
The matter of how nature versus nurture influences human development has been an ongoing discussion for a very long time and, at present, the matter is up to debate, as both nature (genes) and nurture (environmental factors) seem to play a very important role in human development. Education is a fundamental part of intellectual freedom and, one of its main values is enhancing how children view, exist in, and participate in the world (Rothwell, 2013). At the centre of this study will be one of the most popular “misfits” of American literature J.D. Salinger’s Holden Caulfield, who was and will remain a source of inspiration for many teenagers who, one way or another, refuse to accept conformity.
Holden is a young adult who lives in a society which he utterly neglects and the main purpose is to find out if he is indeed a rebel and a misfit or is he just a confused teenager in search of adulthood?
Surveillance of Viral Hemorrhagic Fever Viruses in Lassa Fever Suspects in Ondo State, Nigeria
Authors: Okwuraiwe Azuka Patrick , Faye Oumar , Ige Fehintola Anthonia , James Ayorinde Babatunde , Shaibu Joseph Ojonugwa , Faye Martin , Amoo Olufemi Samuel , NDiaye Oumar , Salu Olumuyiwa Babalola , Omilabu Sunday Aremu , Audu Rosemary Ajuma
Published: June 2022

Lassa Fever (LF) continues to be an endemic acute viral hemorrhagic fever (VHF) illness in Nigeria. Many suspected cases of LF infection have subsequently been confirmed negative and raises concerns as to what the diagnosis of such patients could be. Hence this study was to determine the causative agents of unconfirmed LF among initially suspected cases in South Western Nigeria.
In this retrospective study, blood samples originally collected from 233 suspected cases of a LF outbreak response at Owo and Ose LGAs of Ondo State, were transported in triple level packaging and stored at -80°C. All samples were screened for LF IgM and IgG markers and LF PCR. Forty-five out of the stored plasma samples were randomly retrieved and analyzed for presence of IgM for seven other VHF viruses; Chikungunya (CHIK), West Nile (WN), Rift Valley fever (RVF), Yellow fever (YF), Dengue fever (DEN), Zika and Crimean-Congo hemorrhagic fever (CCHF).
Out of 45 samples screened, 1 (2.2%) was positive for YF IgM antibody. The same sample was previously confirmed LF positive by PCR. This LF and YF co-infection was from a male, 23-year old individual.
The presence of co-infections of LF and YF draw to limelight the need to be broad minded in exploring for the presence of other VHF viruses in outbreaks. Further studies are needed to decipher the diagnosis of LF suspected cases.
Quality of Life of Patients with Advanced Stage Ovarian Cancer from Sanglah Hospital Denpasar: Serial Case Report
Authors: Darmayasa I Made , Padmawati Ni Luh Putu
Published: June 2022

Background: Ovarian cancer is one of the malignancies in women, although it is not contagious, the cases continue to increase. Most ovarian cancers are diagnosed at an advanced stage (stage IIIC or IV). Patients with ovarian cancer can reduce their quality of life, especially at an advanced stage. The quality of life of patients is not only part of the natural history of ovarian cancer, but is also related to the therapy they receive. Especially the administration of chemotherapy or cytostatic drugs.
Methods: This is a report of two cases of the advanced stage of ovarian cancer which were treated in the gynecological oncology room at Sanglah Hospital, Denpasar. The decrease in quality of life in patients with ovarian cancer is illustrated in the case.
Results and Discussion: In the first case, a woman, aged 20 years, complained of abdominal pain and difficulty eating with a history of ovarian cancer. Patients diagnosed with axis 3 with Ovarian Ca post SOD, multiple nodules in the right lung due to metastases, post taping ascites, anemia, and hypoalbuminemia. Patients also experience hypovolemic shock, melena, etc. suspension. SRMD dd/ erosive gastritis. In the second case, a female patient, aged 32 years, was admitted on the 7th day due to abdominal pain, difficulty urinating with a history of ovarian cancer. Patients diagnosed with axis 3 with Ca Ovarian advanced stage, post-SOS, suspected metastases to the left pelvic sidewall, urinary retention after open cystostomy, mild anemia, pain-related neoplasms. Both patients conducted an assessment of the quality of life using the EORTC QLQ-C30 questionnaire. The majority of patients answered the number 4 for each question, which means that the patient is very difficult to carry out basic activities and functions of life. Patients must also be assisted for all activities. Patients choose the number 1 for the quality of health and quality of life which means very bad in this 1 week.
Summary: The quality of life of two cases of advanced-stage ovarian cancer treated in the gynecological oncology room at Sanglah Hospital, Denpasar was poor. It is associated with pain, difficulty performing activities, and basic life functions.
Aburrá- Medellín River Water Quality Space-Time Variation from the Electrical Conductivity and Its Use as an Indicator of Quality.
Authors: Giraldo Buitrago Lina Claudia
Published: June 2022

This article aims to perform a space-time analysis of the electrical conductivity readings measured in the Aburrá - Medellín river, in the period 2006-2020, through the monitoring network of water resources in the region - RedRío, to evaluate the feasibility of using it as an indicator of water quality in the three automatic monitoring stations that are part of this network.

The classification of the flow regime was carried out considering the historical record of flows measured between 2004 and 2020 in the region's water resources monitoring network - RedRío. Then, to evaluate if there were statistically significant differences between the electrical conductivity measured in the stations and for the measurements in the three flow ranges, the non-parametric Kruskal Wallis test was performed, since the assumptions required for an analysis of variance were not met. Finally, to make the state of the river more visible from the electrical conductivity measurements, a categorization by ranges (quartiles) and color assignment is proposed, as established in the ICA water quality indices.

As a result of this study, two classifications of electrical conductivity expressed in five color ranges are proposed, as well as the quality index for surface water – ICA-. Finally, the readings obtained in the automatic stations from August 2019 to March 2020 are reviewed and classification ranges for these stations are adjusted.

This research highlights the proposal to introduce the use of this variable as an indicator of water quality, to illustrate and continuously inform the community about the state of the Aburrá- Medellín river through a color code, to sensitize the inhabitants of the basin on its protection, care, and the importance of efficiently use and save water.
Modelación de la viscosidad dinámica de fluidos newtonianos a partir de la teoría de Eyring y la energía libre de Helmholtz residual
Authors: Cardona Palacio Luis Fernando
Published: June 2022

En este trabajo se modela la viscosidad dinámica de fluidos newtonianos a partir de la teoría de Eyring junto con la energía libre de Helmholtz residual. Para la estimación de esta energía se utiliza una versión modificada de la ecuación cúbica de estado de Peng-Robinson. Los parámetros ajustables del modelo se han determinado a partir de datos experimentales en la zona coexistencia líquido-vapor para n-alcanos y n-alcoholes. Posteriormente estos parámetros se han generalizado utilizando expresiones matemáticas simples que dependen del peso molecular de cada sustancia. Se evalúan las capacidades predictivas del modelo en condiciones de una sola fase. Las desviaciones absolutas durante el proceso de correlación son menores de 3,27%, mientras que en el proceso de predicción son menores de 5,60%. El modelo generalizado es extendido a mezclas binarias utilizando una regla de mezcla simple sin y con coeficientes de interacción, con desviaciones absolutas de 8,19% y 3,45%, respectivamente. Finalmente, el modelo es comparado con otros en la literatura y los resultados estadísticos muestran que proporciona resultados aceptables.
Actividad eléctrica no lineal de las ondas beta cerebrales durante una prueba de atención alternante e inhibición de la interferencia
Authors: Maureira Cid Fernando , Hadweh Briceño Marcelo
Published: June 2022

Introducción: la atención alternante es un proceso que permite cambiar el foco atencional de un estímulo a otro con rapidez. En tanto, la inhibición de la interferencia corresponde a la capacidad de inhibir respuestas automáticas, que permiten responder controladamente frente a estímulos en conflicto. Objetivo: estudiar el comportamiento no-lineal de la oscilación beta (13-30 Hz) del EEG, evaluado a través del balance caos/orden cerebral, durante la ejecución de una prueba de atención alternante y una prueba de inhibición de la interferencia en estudiantes universitarios. Método: la muestra estuvo constituida por 14 estudiantes universitarios varones. Para el registro electroencefalográfico se utilizó el dispositivo cerebro-interfaz Emotiv Epoc® Research Edition utilizando los registros del lóbulo frontal, temporal y occipital. Se analizó el rango de frecuencia de 13 a 30 Hz (onda beta). Para la evaluación de la atención alternante se utilizó la prueba de Smith y para la inhibición de la interferencia se utilizó la prueba de Stroop. Resultados: durante la prueba de atención alternante e inhibición de la interferencia los valores de los exponentes de Hurst tienden a disminuir, lo cual da cuenta de la existencia de procesos más complejos resultados de la desorganización de la actividad de dichas cortezas. Se observan pocas asimetrías entre cortezas izquierdas y derechas, y pocas correlaciones durante la resolución de ambas pruebas. Conclusión: Los exponentes de Hurst tienden a disminuir durante la resolución de la prueba de atención alternante y de inhibición de la interferencia, siendo esto un proceso adecuado para la resolución de problemas cognitivos.
Influencia de la Resolución 0472 de 2017 en las emisiones del sector constructor colombiano
Authors: Pardo Álvarez Nicolás Steven , López Castaño Deisy Jackeline , Rico Pérez María Alejandra
Published: June 2022

Actualmente se reconoce que el sector constructor es uno de los principales generadores de Residuos de Construcción y Demolición (RCD) y emisiones de Gases de Efecto Invernadero (GEI) a nivel mundial. Si bien a nivel nacional existe la Resolución 0472 de 2017 para llevar a cabo una adecuada gestión de los RCD, es importante analizar la influencia del cumplimiento de esta norma en la generación y posible disminución de GEI a nivel nacional. Por esta razón, la presente investigación tiene como objetivo valorar técnicamente la relación entre el componente normativo de gestión de RCD (Resolución 472 de 2017) y la reducción de la huella de carbono en la primera fase del ciclo constructivo, estableciendo como estudio de caso una edificación en altura ubicada en la ciudad de Medellín. Para esto se plantearon cuatro escenarios de cumplimiento de Programa de Manejo Ambiental (PMA) en función de diferentes diseños de mezcla de concreto de 24 MPa de resistencia a la compresión, evaluando además la huella de carbono de cada escenario. Los diseños de mezcla de concreto presentaron la inclusión de aditivos superplastificantes, sustituciones parciales de cemento por ceniza volante y/o sustituciones parciales de agregados vírgenes por agregados reciclados. Los resultados demostraron que para el cumplimiento de la normativa de RCD es estratégica la sustitución parcial de agregados vírgenes por agregados reciclados (escenario 3), pero para la reducción en la huella de carbono es importante la sustitución parcial de cemento por ceniza volante, incluyendo aditivos superplastificantes (escenario 2). Por lo tanto, el escenario 4 que vincula todas las estrategias mencionadas presenta altos porcentajes de cumplimiento de la normativa (17,2% frente a 11,3% del escenario base) y una reducción en la huella de carbono (338,1 kg CO2/m2 frente a 438,1 kg CO2/m2 del escenario base).
Prospects of PARP Inhibitors in Treatment of BRCA-Mutated Pancreatic Cancer: a Literature Review
Authors: Menshikov K. V. , Sultanbaev A. V. , Musin Sh. I. , Izmailov A. A. , Menshikova I. A. , Sultanbaeva N. I. , Popova E. V. , Khammatova L. A.
Published: June 2022

Pancreatic adenocarcinoma has a  5-year overall survival rate of 9 %, with an outlook of becoming the second leading cause of cancer mortality in the USA by 2030. Familial pancreatic cancer and genetic predisposition syndromes have attracted more interest in the perspective of targeted therapy. Various authors estimate genetic causes to account for 10–15 % of pancreatic cancers. The BRCA gene mutations comprise the today’s most relevant genetic predisposition syndrome. The frequency of BRCA1/2 and PALB2 germinal mutations in patients with pancreatic adenocarcinoma constitutes about 5–9 %. Over recent years, PARP inhibitors (PARPi) have composed a new targeted therapy class with a significant effect in breast and ovarian cancers. With the mechanism of action of the PARP inhibitor and platinum drugs targeting different DNA repair pathways, their combination therapy has been suggested as promising. We report studies of a combination treatment with veliparib, gemcitabine and cisplatin in germinal BRCA1/2-mutation patients with advanced wild-type pancreatic adenocarcinoma (WT). Recent advances have identified patients with germinal and somatic mutations in the BRCA1/2 and other genes. HRD-targeted therapy, including platinum and PARP inhibitor drugs, can significantly improve survival.
Analisis Kesulitan Belajar dalam Pembelajaran Daring Pada Muatan IPA di Sekolah Dasar
Authors: Novitasari Shofia , Setiawan Deka , Masfuah Siti
Published: June 2022

This study aims to analyze learning difficulties in online learning on science content during the pandemic at SDN Wegil Sukolilo Pati.This study uses a qualitative research approach with a descriptive type of research. Data collection carried out by researchers includes observation, interviews, and documentation techniques by collecting relevant sources and then analyzed using data cards. The research was carried out at SDN Wegil Sukolilo Pati using research subjects, namely the fifth grade teacher and 3 fifth grade students with a record of 1 student who has high ability, 1 student who has moderate ability, and 1 student who has low ability.Based on the results of research that has been carried out in class V SDN Wegil Sukolilo Pati, it can be concluded that the implementation of learning is in accordance with Circular Letter Number 3 of 2020 and the learning process in class utilizing digital technology used is WhatsApp Grub where there are difficulties in learning in learning thematic content of IPA. There are two factors that cause students to have learning difficulties, namely internal and external factors. Internal factors that influence it: 1) lack of student motivation in online learning, 2) lack of student attention in the learning process, 3) students' slowness in understanding the material. While the external factors that influence it are: 1) Students who do not have their own facilities in supporting the learning process, namely cellphones, 2) the influence of friends in the community who always play.
Inovação em cooperativas para uma transição energética na Região Centro/RS
Authors: Brose Markus Erwin
Published: June 2022

A Política Gaúcha sobre Mudanças Climáticas estabeleceu que o Estado seria responsável pelo redirecionamento da economia para a adaptação climática. Ao longo da primeira década, componentes centrais para a adaptação, como a transição energética ou a expansão da bioeconomia, não se tornaram políticas públicas. Esse artigo busca contribuir ao argumento, ainda pouco valorizado no debate, de que o cooperativismo apresenta potencial significativo para o avanço dessa agenda. Para tanto, utiliza a abordagem policêntrica, desenvolvida por Elinor Ostrom, na interpretação de que a transição rumo à maior sustentabilidade no Rio Grande do Sul pode ocorrer a partir de inovações simultâneas e independentes em múltiplas escalas. Visando a concretizar esse argumento, o artigo registra quatro inovações em curso na Região Centro, estabelecidas de forma autônoma e voluntária por parte de cooperativas em suas áreas de atuação. Entre os resultados, destaca-se que essas iniciativas permitem a democratização do controle sobre o capital, a redução das emissões de gases de efeito estufa, assim como a geração de energia de fontes renováveis, oportunizando novas cadeias produtivas no meio rural e evitando o imobilismo de aguardar pela ação do Estado.
Palavras-chave: Adaptação climática. Geração distribuída. Bioeconomia. Cooperativismo.
cooperativismo como estratégia de fortalecimento da agricultura familiar na Bahia
Authors: Anjos Eliene Gomes dos , Rocha Ana Georgina Peixoto , Silva Daciane de Oliveira
Published: June 2022

O avanço do cooperativismo da agricultura familiar tem sido considerado uma estratégia para o fortalecimento dessa categoria, com efeitos positivos nos territórios rurais. Essa expansão apresenta dinâmicas diferentes, refletindo contextos específicos da realidade brasileira e de sua agricultura familiar. Esse artigo objetiva discutir as condições socioeconômicas dos agricultores familiares da Bahia, com foco nos estabelecimentos agropecuários familiares inseridos em cooperativas. Busca-se dimensionar o papel que o cooperativismo tem desempenhado no fortalecimento da agricultura familiar no estado. A metodologia foi baseada nos dados do Censo Agropecuário 2017, na base de dados Sidra, a partir da escolha de variáveis selecionadas agregadas nas seguintes informações: características dos estabelecimentos agropecuários e dos produtores, da movimentação financeira e pessoal ocupado. Os resultados apontam que a inserção em cooperativas contribui, em certa medida, para alterar aspectos produtivos/comerciais e socioeconômicos dos agricultores familiares cooperados da Bahia, com uma maior produção direcionada para a comercialização, importância da renda obtida nos estabelecimentos e mais assistência técnica. Como conclusão, apontam-se avanços, mas, também, a persistência da vulnerabilidade social de grande parte da agricultura familiar.
Palavras-chave: Cooperativas. Agricultores familiares. Desenvolvimento territorial.
Serotonin receptor subtype-2B signaling is associated with interleukin-18-induced cardiomyoblast hypertrophy in vitro
Authors: Chen Chao-Yi , Leu Jyh-Gang , Lin Kuan-Yu , Shih Chin-Yu , Liang Yao-Jen
Published: June 2022

Background

In patients with heart failure, interleukin-18 (IL-18) levels increase in the circulatory system and injured myocardial tissue. Serotonin (5-hydroxytryptamine) receptors subtype 2B (HTR2B) play an essential role in cardiac function and development, and their overexpression in rats leads to myocardial hypertrophy. Epigallocatechin gallate (EGCG) is cardioprotective in myocardial ischemia–reperfusion injury in rats and can prevent pressure overload-mediated cardiac hypertrophy in vivo. Mice deficient in peroxisome proliferator-activated receptor delta (PPARδ) can have cardiac dysfunction, myocardial hypertrophy, and heart failure. Matrix metalloproteinases (MMPs) are possibly involved in cardiac remodeling. However, the relationship between IL-18 signaling, cardiac hypertrophy, and the molecular mechanisms involved remain to be fully elucidated.

Objectives

To elucidate the relationship between HTR2B and IL-18-induced myocardial hypertrophy and examine the antihypertrophic effects of EGCG and PPARδ.

Methods

We induced H9c2 cardiomyoblast hypertrophy with IL-18 in vitro and investigated the downstream signaling by real-time polymerase chain reaction (PCR) and western blotting. Hypertrophy was assessed by flow cytometry. We determined the effects of EGCG and PPARδ on IL-18-induced hypertrophic signaling via HTR2B-dependent mechanisms.

Results

IL-18-induced H9c2 hypertrophy upregulated brain natriuretic peptide (BNP) protein and mRNA expression by inducing the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and the hypertrophy was attenuated by pretreatment with EGCG (20 μM) and L-165,041 (2 μM), a PPARδ agonist. IL-18 upregulated the expression of HTR2B, which was inhibited by pretreatment with EGCG and L-165,041. SB215505 (0.1 μM), a HTR2B antagonist and siRNA for HTR2B, attenuated H9c2 hypertrophy significantly. Inhibition of HTR2B also downregulated the expression of MMP-3 and MMP-9.

Conclusions

IL-18 and HTR2B play critical roles in cardiomyoblast hypertrophy. EGCG and L-165,041 inhibit the expression of HTR2B and augment remodeling of H9c2 cardiomyoblasts, possibly mediated by MMP-3 and MMP-9.
PENGARUH STATUS MIGRASI, PEKERJAAN, PENDIDIKAN, DAN LATAR BELAKANG EKONOMI TERHADAP UKP DAN FERTILITAS WANITA USIA SUBUR
Authors: Jayakusuma I Made Wisnu , Sudibia I Ketut
Published: June 2022

This study aims to analyze 1) the effect of migration status, employment status, education level, and economic background on the age at first marriage of women of childbearing age in Badung Regency; 2) The effect of migration status, employment status, education level, economic background, and age at first marriage on the fertility of women of childbearing age in Badung Regency; 3) Indirect effect of migration status, employment status, education level, economic background, and age at first marriage on the fertility of women of childbearing age in Badung Regency. The data analysis technique used is descriptive statistics and inferential statistics consisting of path analysis and Sobel test. The results showed 1) Migrant women have a lower age at first marriage than non-migrant women, women who work in the informal sector have a lower age at first marriage than women who work in the formal sector, education level has a positive and significant effect on age at first marriage, while economic background has a negative and significant effect on age at first marriage; 2) Migrant women have a higher fertility rate than non-migrant women, women who work in the informal sector have a higher fertility rate than women who work in the formal sector, education level has a negative effect on fertility, while economic background has no significant effect on fertility, and age at first marriage has a negative effect on the fertility of women of childbearing age in Badung Regency; 3) Age at first marriage mediates the effect of employment status, education level, and economic background on fertility, but does not mediate the effect of migration status on fertility of women of childbearing age in Badung Regency.
PERANCANGAN SISTEM INFORMASI MANAJEMEN KEPEGAWAIAN BAGI UKM BERBASIS DIGITAL
Authors: Astitiani Ni Luh Putu Surya , Widnyani Ni Made
Published: June 2022

Saat ini teknologi informasi memegang peranan dalam penyelesaian suatu permasalahan guna meningkatkan efektifitas dan efisiensi kerja dalam sebuah perusahaan bisnis. Tidak hanya itu teknologi informasi juga dapat mempermudah dan mempercepat sebuah proses bisnis dalam suatu perusahaan. UKM saat ini dapat memanfaatkan teknologi informasi dalam untuk pengelolaan bisnis. Salah satu teknologi yang dapat dimanfaatkan oleh UKM adalah sistem informasi manajemen kepegawaian berbasis digital. Keberhasilan sebuah usaha sangat tergantung dengan adanya manajemen yang baik terutama pengelolaan sumber daya manusia atau pegawai. Selama ini masih banyak pengusaha UKM yang belum melakukan pengelolaan kepegawaian secara tersistem terlebih memanfaatkan teknologi infomasi. Menyadari situasi dan kondisi tersebut di atas, maka diperlukan sebuah sebuah sistem informasi kepegawaian berbasis digital bagi para pengusaha UKM. Dalam penelitian ini akan dibuat perancangan sistem informasi manajemen kepegawaian bagi UKM berbasis digital. Sistem ini diharapkan mampu membantu dan memudahkan pengusaha UKM dalam mengelola data dan menilai kinerja pegawai, sehingga dengan adanya sistem ini pengambilan keputusan lebih cepat dan mudah dapat dilakukan.
ANALISIS HUBUNGAN BAURAN PEMASARAN 7P TERHADAP KEPUTUSAN PEMBELIAN KATERING SEHAT BERDASARKAN INDIKATOR ASPEK KEPUASAN, LOYALITAS, SERTA HUBUNGAN PASCA PEMBELIAN PERIODE SEBELUM DAN SELAMA PANDEMI
Authors: Wilandari Angestika , Windasari Vicky
Published: June 2022

Basically, consumer purchasing decisions can be influenced by the marketing mix, namely the 7Ps (product, price, process, place, promotion, people, and physical evidence). This study examines how the 7P marketing mix variables affect healthy catering purchasing decisions. Purchasing decisions in this study use indicators of satisfaction, loyalty, and post-purchase relationships. This research is quantitative with data collection methods through questionnaires and secondary data collection. The population in this study is unknown, so in determining the number of samples using the Isaac & Michael table for the population that cannot be determined. The sampling technique is non-probability sampling using incidental sampling method. The data analysis technique starts from the reliability and validity test, the classical assumption test, the partial t test, the F simultaneous test, and the coefficient of determination test. The results showed that in the pre-pandemic period the independent variable in the form of the 7P marketing mix other than product and location had a significant positive effect on purchasing decisions. The results for the second model show that product, price, and physical evidence variables have a significant effect on healthy catering purchasing decisions during the pandemic
KUALITAS DAN TINGKAT PENCEMARAN AIR WADUK TITAB, BULELENG
Authors: Dewi Ayu Meiliana Laksmi , Juliasih Ni Ketut Ayu , Arsana I Nyoman
Published: June 2022

Monitoring water sources is essential to ensure the quality and quantity, one of which is in the Titab Reservoir. The purpose of the study was to assess the water quality and amount of pollution in the Titab reservoir in terms of physical, chemical, and microbiological characteristics, as well as the NVC of Tawes (Barbonymus gonionotus) fish. There are five station points for water sampling and 10 test parameters related to water quality. Data analysis compares test results with second-class water quality standards (Bali Governor Regulation No. 16/2016), IP value (pollution index), and NVC with Furton's equation. The test results obtained that the water in the Titab reservoir has a temperature of 28.97oC, TSS (0.18 mg/L), pH (8.82), BOD (3.22 mg/L), COD (16.70 mg/L), DO (6.77 mg/L), Total Phosphate (0.12 mg/L), Nitrate (0.19 mg/L) and Fecal Coliform (960 MPN/100 mL), the IP value was 1.39, and the NVC was 1.65. Thus, the pH, BOD, and Fecal Coliform levels of the Titab reservoir water did not match the specified limits, although the other parameters satisfied the water quality norms. The Titab reservoir's water is classed as mildly contaminated with the NVC value of tawes fish, referring to the Titab reservoir's polluted water.

Keywords: Tawes Fish, Titab Reservoir, Water pollution, Water quality.
EFEKTIVITAS PEMANFAATAN KULTUR LOKAL DALAM BIOREAKTOR PENGOLAHAN AIR LIMBAH KERAJINAN ENDEK
Authors: Juliasari Ni Made Tia , Budiarsa Suyasa I Wayan , Rai I Nyoman
Published: June 2022

Endek is one of the fabrics that are in demand by local and foreign people. The distinctive pattern of this endek cloth continues to develop while still paying attention to the authenticity of the endek motives from Bali so that it is easily recognized by the public, however, in its production, it produces waste that causes environmental pollution therefore it needs to be managed. One of the easy and efficient textile waste management is a bioreactor by utilizing local culture. Local cultures are indicated as indigenous microorganisms originating from the waste itself. The purpose of this study is to analyze the effectiveness of local cultures in bioreactors in improving wastewater quality and analyze the effectiveness of using local microbial cultures in bioreactors for treating endek wastewater. This study applied a quantitative approach with experimental methods. The processing begins with the growth of biofilms to determine the biomass profile using the Mixed Liquor Suspended Solid (MLSS) method, then the color waste water is stored in an anaerobic reservoir for 24 hours then tested and then processing, later it is inundated for 1 hour before parameter measurement. The parameters tested were COD levels, color content and pH. Based on the results of the study, the optimum MLSS value obtained in the seeding process was 4490 mg/L on the 7th day and the biofilm growth biomass profile of 3240 mg/L on the 22nd day. The utilization of local microbial culture in the bioreactor in this study was effective in reducing the color content parameter by 77% at processing times of 384 and 408 hours, and decreasing pH was only effective at processing time of 6 hours and reducing COD was not effective.

Keywords : endek wastewater, local culture, bioreactor, effectivenes