bluuebunny/crossref_metadata_2025 huggingface dataset:
P05-01 Change in cardiorespiratory fitness in midlife and incident hypertension
Authors: Holmlund Tobias , Ekblom Björn , Ekblom-Bak Elin
Published: August 2022

Background

Low cardiorespiratory fitness (CRF) is associated with higher blood pressure and risk of incident hypertension. However, existing literature has mainly investigated CRF at baseline. For HEPA initiatives, it is important to know how change in CRF in midlife associate with incident hypertension, and whether this varies between sexes, age and baseline CRF.

Methods

91,728 individuals (20-79 years, 48% women, free from hypertension at baseline) from the Swedish workforce who had completed two health profile assessments in a nationwide occupational health service screening between 1986 and 2019 were included. CRF (assessed as VO2max) was estimated using a submaximal cycle test. Change in CRF between the two tests was expressed as % change in absolute CRF (L·min-1) per year and categorized as “maintainers” (-1% to 1% change/year), “decreases” (≥-1% change/year) or “increasers” (≥1% change/year). Incident hypertension was defined as having a blood pressure >140/90 mmHg or diagnosed with hypertension at the second test. Binary logistic regression was used to assess OR (95% CI) for hypertension at the second test between maintainers, decreases and increasers. All analyses were adjusted for sex, age, heart medication, time between tests, education, and change in other lifestyle variables between the two tests (stress, diet, exercise, smoking).

Results

Compared to maintainers (set as reference), OR for decreases was 1.27 (1.18-1.38) and increasers OR 0.99 (0.89-1.09). Isolating midlife participants (40-60 years), OR for decreasers was 1.47 (1.30-1.66) and increasers OR 0.75 (0.64-0.86). Looking at sex differences, male decreasers had OR 1.24 (1.12-1.36) and female decreasers OR 1.36 (1.20-1.56), compared to maintainers, while OR for male and female increasers was 0.93 (0.83-1.03) and 0.97 (0.83-1.13). For participants with low CRF at baseline (<32·kg-1·min-1), OR for decreasers was 1.70 (1.51-1.92) and increasers 1.32 (1.18-1.49). Corresponding ORs in those with high CRF at baseline were 0.90 (0.80-1.02) and 0.43 (0.26-0.71).

Conclusions

Decrease in CRF with >1% per year associated with significant higher risk for incident hypertension, while maintaining or increasing CRF had similar risk associations. This was seen in both men and women, different age-groups and baseline level of CRF. Health enhancing promotion strategies to maintain or increase CRF level is highly clinically relevant.
P06-04 Agreement between single item physical activity measures in population surveillance in New Zealand
Authors: Adrian Bauman , MIzdrak Anja , Gage Ryan , McEwan Hamish , Richards Justin
Published: August 2022

Background

Sport New Zealand conducts continuous physical activity and sport “Active NZ” surveys, conducted since 2017; these survey around 20,000 representatively sampled adults annually (response rate 29-32%, data weighted to NZ Census population). There has been international interest in “single item” physical activity questions to estimate and monitor physical activity levels. Validated questions for adults have asked about the number of days in the past week people were active for > =30 mins for leisure or transport (SI-days). The Active NZ surveys also ask IPAQ-long form questions and a new single item question on the number of hours people were active in sport/recreation in the past 7 days (SI-hours). The public health problem is that the validated SI-days question cannot directly estimate the WHO recommended threshold of 150+ mins of PA/week. This study describes the prevalence of these questions, and examines the relationships between SI-days, SI-hours and IPAQ-long form [using 600 total PA met-mins as the threshold approximating 150 mins of moderate PA, and also using the leisure time domain only in IPAQ).

Methods

Analyses were descriptive, and inter-method comparisons using Spearman's correlations, and the best fit with the PA thresholds were estimated using Area under the ROC curve (AUC) and Youden's Index.

Results

IPAQ and SI-days were only collected mid 2019 to early 2020 (n = 15044). SI-days showed a mean of 3.2 days (SD=2.2), SI-hours 5.3 (SD=6.2), and SI-hours 150 mins+ was reported by 60.6%. 88.2% reached the IPAQ-total met threshold, and 41.4% met the IPAQ leisure only threshold. Correlations between SI measures and IPAQ were 0.22 for IPAQ-total, and ∼ 0.45 for IPAQ-leisure. SI-days and SI-hours were correlated rho=0.51. ROC curve analyses showed AUC values with IPAQ measures were between 0.63 to 0.76, but the SI-days showed a good AUC of 0.82 (0.81-0.83) with the SI-hours 150 mins threshold. Youdens index suggested the best fit was at 3+ days/week were most likely to meet the SI-hours threshold.

Conclusion

These data show SI questions reflect health enhancing thresholds well, and that those reporting >3 SI days showed best fit with the 150mins threshold based on SI hours, indicating good surveillance utility.
P06-08 Socio-demographic profile of physically inactive adults living in Italy according to the PASSI data
Authors: Minardi Valentina , Possenti Valentina , Gallo Rosaria , Contoli Benedetta , Lana Susanna , Masocco Maria
Published: August 2022

Background

Insufficient physical activity (PA) or physical inactivity (PI) is one of the ten leading risk factors for global mortality. PI leads to 20-30% increased risk of all-cause mortality and monitoring its current levels and trends in general population is essential to track progress towards health targets, identify at-risk groups, assess policies' effectiveness, guide future planning.

Methods

PASSI (Progressi delle Aziende Sanitarie per la Salute in Italia - Progresses in ASSessing adult population health in Italy) is an ongoing cross-sectional Behavioral Risk Factor Surveillance System (BRFSS) that monitors prevalence and temporal trends for the major modifiable health-related risk factors in the adults (18-69 years) residing in Italy. Data are collected in the Local Health Units (LHU) by trained personnel who administer a standardized questionnaire telephonically to sampled people. In the period 2015-2018, 132,717 people were interviewed in more of 90% LHUs (89 out of 101 in 2018), achieving a response rate above 80%. Concerning PA/PI, respondents are classified as per the WHO indicators in: (i) Active - basing on levels achieved in leisure time and/or heavy work; (ii) Partially active - in leisure time and/or moderate work or in spare time and without regular work; (iii) Inactive - in leisure time with sedentary work or in spare time and without regular work. PASSI calculates prevalence of PA/PI overall and by socio-demographic characteristics, including 95% confidence intervals (CI), and a logistic regression model estimates adjusted prevalence ratios (APR).

Results

In Italy, 28.8% (CI95%:28.5-29.1%) of adult population is featured by a sedentary lifestyle: PI is greater among women (32.4% vs. 25.1%; APR: 1.26), grows with age (34% in over50 vs. 24.7% among 18-34 year-old; APR: 1.34), is higher among deprived people both per economic difficulties (41.7% if many vs. 22.4% if none; APR: 1.39) and for education level (23.7% university vs. 47.2% primary/any; APR: 1.33). We observed a highly evident geographic gradient: PI amounts to 18.3% in the North, 25.2% in the Centre and 40.6% in the South. A multivariate analysis confirms these values are statistically significant.

Conclusions

PASSI data provide strong evidence to support community prevention interventions on territorial planning or advice by health professionals.
P06-09 Data processing with the short questionnaire to assess health enhancing physical activity (SQUASH): an update
Authors: Duijvestijn Marjolein , de Hollander Ellen , van den Berg Saskia , Wendel-Vos Wanda
Published: August 2022

Background

The Short Questionnaire to Assess Health Enhancing Physical Activity (SQUASH) is a widely used questionnaire, and used for monitoring prevalence rates of physical activity(PA) in the Netherlands. To provide a standardized protocol for data processing and analysis of the SQUASH, an analysis guide was published in 2004. However, since then, the compendium of Metabolic Equivalent (MET) values of PA has been updated, and new PA guidelines have been developed. The new PA guidelines differ from the old ones in terms of the appropriate amount of active time (150 minutes/week versus 5 days/week 30 minutes), decrease in cut-off point for moderate intensity (adults 18-54 years of age) and adding a bone- and muscle strengthening component. Therefore, the protocol for data processing and analysis of the SQUASH needs to be updated. In this study, results from the old and new protocol demonstrate the differences in adherence rates between the two sets of guidelines in the Netherlands for the adult population.

Methods

Data of a nationally representative sample of 6942 participants aged 18 years and older were used to calculate adherence to the old and the new PA guidelines by using the original and the updated protocol. In the new protocol, the MET-values of the activities including sports were adjusted according to the 2011 Compendium. Moderate intense activity was defined as ≥ 3.0 MET irrespective of age and the bone and muscle strengthening component was added.

Results

Adherence to the old Dutch PA guidelines is 48.1% among adults aged 18-54 years, and 74.4% among adults 55 years and older. For the new PA guidelines the adherence is 48.4% and 38.1% respectively. The large difference for adults 55 years and older is due to changes in the cut-off values for moderate-to-vigorous intensity PA and the addition of bone and muscle strengthening exercises.

Conclusions

The updated protocol for data processing and analysis of the SQUASH describes the steps to calculate the new PA guidelines in a structured way and gives researchers the opportunity to work with the data from the SQUASH in a uniform way. The SPSS syntax for data processing is available at: www.sportenbewegenincijfers.nl/methoden.
P06-15 What makes physical activity interventions work in Ireland: findings from interviews with those involved with intervention implementation
Authors: Murphy Joey
Published: August 2022

Background

Understanding the common facilitators and challenges experienced by those implementing physical activity (PA) interventions in Ireland is crucial for both promoting good practices and solutions to overcome such challenges in the future. The purpose of this study was to interview relevant stakeholders to identify factors associated with implementing PA interventions in Ireland.

Methods

Semi-structured interviews were conducted with service providers, coordinators, funders, researchers and policy makers involved with selected PA interventions (N = 11) in Ireland. The Consolidated Framework for Implementation Research (CFIR) was used to guide the generation of an interview script including key questions and prompts. Prompts were identified through a short survey that was completed by participants before the interview. Interviews lasted approximately one-hour and were conducted by the same interviewer, either in person or over the phone, and recorded using a Dictaphone. All interviews were transcribed and cleaned before being analysed using NVIVO. Open coding, using the CFIR domains as a guide, was used to generate and agree on a code book to analyse all interviews. Once open coding was complete, thematic analysis was used to identify themes in the data related to implementation facilitators and challenges.

Results

Thirty-eight purposely sampled participants took part in the semi-structured interviews (26.3% service providers, 31.6% coordinators, 10.5% funders, 15.8% researchers, 15.8% policy makers). Some themes related to 1) intervention characteristics included usability, costs, fidelity and practical considerations, 2) characteristics of individuals included constraints, knowledge and attitudes, 3) inner setting included support, staffing, understanding or awareness, 4) outer setting included role responsibility, context changes, partnerships, 5) processes of implementation included advertisement, deliver and scale-up. Relationships were also noted between themes. For example, themes identified for funding and stakeholder engagement were found to influence multiple domains of the CFIR framework.

Conclusion

Findings from these interviews help to understand the complexity of implementing PA interventions in the Irish context. Furthermore, the findings can be used to aid implementation through the facilitators identified and provide solutions to common challenges experienced by those involved in implementing PA interventions. Future work will see the creation of an implementation toolkit using these findings.
P07-01 Prescription of adapted physical activity: knowledge and needs among general practitioners of Ile-de-France
Authors: Astruc Alexis , Blanchard Jean-Christophe
Published: August 2022

Background

Physical inactivity is the fourth leading cause of death in the world. In France, the concept of medical prescription of physical activity (PA) adapted now appears in a law which specifies the central role of the family physician since December 2016. The needs of the general practitioners (GP) about prescription of PA has not been studied.

Aim

To assess the knowledge and needs of GPs regarding the medical prescription of PA.

Methods

This is a transversal observational epidemiological study of GPs working in the departments of Hauts-de-Seine (92) and Val-de-Marne (94) near Paris. A questionnaire was sent by mail or email. A descriptive statistical analysis was conducted to describe the main variables of interest. Then, a multivariate statistical analysis by logistic regression was conducted to look for independent factors of the feeling of competence in the prescription of adapted PA.

Results

158 physicians were included. 72.2% of GPs rated their knowledge in PA as average to very poor. The initial training in PA is estimated as unsatisfactory by 84.2% of GPs. 81.6% haven't done a postgraduate additional training in PA. A specific skill in sports medicine, the individual practice of PA as well as the speaking about PA in more than 50% of consultations are significantly associated with a feeling of competence in PA prescription (p >0.01).

Among the measures favoring the prescription of PA, GPs told that they need information brochures to give to the patient (60.8%), a website of help to the prescription of PA which can be used in consultation (60.1%), or the organization of a specific training on the medical prescription of AP (50,6%).

Conclusion

The lack of training seems to be the major obstacle to the generalization of prescription of PA. The organization of training or the creation of specific tools for the attending physician seems to be promising solutions.
P08-10 Clustering of unhealthy lifestyle factors in occupational groups in the Swedish workforce
Authors: Väisänen Daniel , Kallings Lena , Hemmingsson Erik , Ekblom-Bak Elin
Published: August 2022

Background

The physical activity pattern of the population, as well as the tasks of different occupational groups, have changed over the past decades. Hence, studies within and between different occupational groups, and not just between white and blue collar workers, are central for current risk group analyses. The aim was to study clustering of unhealthy lifestyle factors in different occupational groups in a large sample of men and women from the Swedish working population.

Methods

72,855 individuals aged 18-75 years (41% women) from the Swedish working population who participated in a nationwide occupational health service screening between 2014-2019 were included in this cross-sectional descriptive study. Nine different occupational groups were identified based on the International Standard Classification of Occupation 2008. Exercise, diet, smoking habits and perceived health were self-reported. Cardiorespiratory fitness was estimated using a submaximal cycle test. Blood pressure and BMI was assessed through physical examination. Logistic regression modelling assessed OR (95%CI) for clustering of unhealthy lifestyle factors, defined as ‘3 of the following; low exercise, poor diet, daily smoking, poor perceived health, low fitness, high blood pressure and high BMI in the different occupational groups.

Results

The OR (95% CI) for clustering of unhealthy lifestyle factors were, compared to managers that served as reference, 1.00 (0.89-1.11) for professionals, 1.25 (1.11-1.39) for associate professionals, 1.93 (1.71-2.18) for clerical support workers, 2.40 (2.14-2.70) for service and sales workers, 1.63 (1.29-2.05) for agricultural, forestry and fishery workers, 2.23 (1.99-2.49) for craft and related trades workers, 2.52 (2.25-2.83) for plant and machine operators, and assemblers, and 2.62 (2.26-3.05) for elementary occupations. Comparing occupational groups within ‘service and sales workers’ and ‘plant and machine operators, and assemblers’, revealed significantly higher OR for professionals in care workers (OR2.92 (2.55-3.34)) and in drivers (OR 3.32(2.86-3.87)) compared to each of the main occupational groups.

Conclusion

There were large variations in clustering of unhealthy lifestyle-related factors between as well as within different white and blue collar occupations. This study suggest that targeted measures of health promotion are foremost needed in blue collar occupations, however with some white collar sub-occupations being at similar need as blue collar occupations.
P08-13 Physical activity increases social inclusion
Authors: Steffansson Marina , Pehkonen-Elmi Tuula
Published: August 2022

Background

Studies show that exercise improves self-esteem and improved self-esteem strengthens inclusion and prevents marginalization. Young people who have only completed primary school may incur additional costs of up to 370 000 euros for public administration over their lifetime, compared to those who educate themselves. In Pieksämäki, a physical activity intervention was developed for physically inactive young people not in education, employment or training (NEET) and it aims to improve their activity and thereby their social inclusion. The aim of the study was to evaluate the outcomes and the cost of the intervention.

Methods

The physical activity intervention includes a personal physical exercise plan, individual instruction and free access to the swimming hall and gym during the participation. Each participant gets as much guidance as they need. We present results only for three cases, because the target group was very challenging. The follow-up period was 12 months.

Results

To evaluate the outcomes we used three subjective measures, 3X10D® (survey-self-evaluation tool), the Abilitator®, and 15D (HRQoL, the health-related quality of life instrument). The 3X10D® showed that life as a whole and self-esteem improved in two cases. In all three cases managing in daily activities improved. However, the Abilitator® showed slight improvement in wellbeing and clear improvement in physical functioning in all three cases. We obtained 15D results only from two cases. In one case HRQoL decreased slightly and in the other one it increased significantly. The employment status of these three cases changed. In the beginning there was an unemployed person, a person having only 9-year basic education and a drop-out from vocational education. After the intervention the unemployed person was working, and the other two were studying. Depending on the number of visits to the physical exercise instructor and other physical activities the costs of the intervention varied between 1042 and 1215 euros.

Conclusions

Based on the results physical functioning and self-esteem improved and that can lead to stronger social inclusion. Although the three individuals underwent intensive individual instruction, the costs were low compared to the costs of social exclusion reported in earlier researches.
P08-16 Neighborhood walkability and older people's participation in leisure activities
Authors: Tuomola Essi-Mari , Keskinen Kirsi , Rantanen Taina , Portegijs Erja
Published: August 2022

Background

The neighborhood environment may enhance or restrict older people's opportunities to participate in leisure activities, and thus impact quality of life. Walkability depicts the environment's suitability for walking to different destinations. Little is known concerning about the relation between environment walkability and participation in leisure activities. Our purpose was to study whether neighborhood's objective and perceived walkability were related to participation in various leisure activities outside the home.

Methods

Cross-sectional data of LISPE consisted of 848 community-dwelling people aged 75-90 living in the municipalities of Jyväskylä and Muurame, Finland. Participants' home addresses were geocoded, and walkability index (mixed land-use, street connectivity, and population density) was calculated using geographic information system and categorized into tertiles. From a checklist, participants chose all infrastructure-based facilitators present in their neighborhood, which draw them to outdoor mobility (e.g., good lighting, services close); the sum of these was used as an indicator of perceived walkability. Participation in leisure activities outside the home was self-reported based on frequency and classified as participation (yes/no) in group activities (≥1x/week), physical activity (≥1x/week), and non-group cultural and other activities (≥1x/month). For each leisure activity type, logistic regression models were conducted for walkability index and perceived walkability separately. Analyses were adjusted age, sex, years of education, weekly car use, walking difficulties, and number of chronic conditions.

Results

Logistic regression showed that the older people who lived in areas with high walkability index were more likely to participate in cultural and other activities activity at least once a month (OR = 1.64, 95% Cl = 1.14-2.36) and less likely to participate in physical activity at least once a week (OR = 0.61, 95% Cl = 0.39-0.94, fully adjusted model) than older people living in areas with low walkability index. Older people reporting higher perceived walkability participated more often in physical activity than those who reported lower walkability (OR = 1.14, 95% Cl = 1.05-1.23).

Conclusions

Living in the area of high walkability enhanced participation in cultural activities and decreased participation in physical activity. However, higher perceived walkability may motivate older people to be physically active. Environment which offers good infrastructure for outdoor mobility provides opportunities to participate in specific leisure activities.
P09-04 Sedentary time measured by GT3X+ accelerometry and its variation with grade level and gender among children and adolescents in Morocco
Authors: El Hamdouchi Asmaa , El Harchaoui Imane , Benjeddou Kaoutar , El Menchawy Imane , Safsaf Naima , Saeid Naima , El Kari Khalid , Elmzibri Mohammed , Baddou Issad , Aguenaou Hassan
Published: August 2022

Background

Sedentary behavior (SB) in children is related to different health outcomes such as overweight and cardio-metabolic diseases. These negative effects have been widely supported by evidence. However, no data on sedentary time (ST) among Moroccan children has been available, yet. Therefore, the present study examined gender and grade differences in objectively measured sedentary behavior in a sample of Moroccan primary school children and adolescents.

Methods

In total, 172 Moroccan children/adolescents aged between 8 to 14 years old (mean age = 10.92 ± 1.55 years; 49.4% were boys) completed the survey. School grade, gender, height, and weight were collected by questionnaires and ST objectively measured using a tri-axial accelerometer (GTX3+). Study required at least 3 valid weekdays and 1 weekend day with? 600 min/day total wear time. Two-way analysis of covariance and logistic regression analyses, adjusted for BMI z-score and accelerometer wear time, were used to examine gender and grade differences in ST.

Results

Mean time spent in SB was 535.93 ± 87.15 min/day or ∼ 62.94% of the average daily accelerometer wear time of 851.45 ±51.35.min/day with statistical differences between weekend and week days (471.357 ± 127.73 minutes/day vs. 559.7661± 90.75 minutes/day; p > 0.001). Adolescents (11-14y) were more involved in sitting tasks when compared to the early grades (8-10y). 550.011±88.827 vs. 521.845±83.602 respectively; p > 0.001.

Conclusion

ST increases between ages 11 and 14 years. On week days children and adolescents spent sitting longer than at weekends. Girls and adolescents were identified as potential risk groups. This report on ST presents valuable information for designing and implementing interventions to decrease time spent in SB among children during class time.

Acknowledgements

This study was performed with the support of the International Atomic Energy Agency (CRP E4.30.24; RAF 6042).
P09-06 Getting a grip on sitting behaviour
Authors: Duijvestijn Marjolein , van den Berg Saskia , Wendel-Vos Wanda
Published: August 2022

Background

Sedentary time (sitting) has been associated with adverse cardio-metabolic consequences. The general recommendation is to interrupt long periods of sitting. In order to successfully develop interventions and policies to decrease sedentary behaviour, high-risk groups as well as the context of sitting should be identified. The aim of this study was to investigate sedentary behaviour among (subgroups of) the Dutch population and to identify in which domains most sedentary time was spent.

Methods

Data from the 2017 Dutch national Health Interview Survey was used, which includes a nationally representative sample of 8,441 Dutch citizens aged 4 years and older. Sedentary time on an average day was assessed using an adjusted version of the Marshall questionnaire. Sitting domains were defined as: 1) traveling, 2) at work, 3) at school or studying 4) watching television, 5) using a computer/smartphone at home, and 6) otherwise. Total sedentary time was analysed stratified by age, sex and level of education with ANOVA and Bonferroni correction.

Results

On average the Dutch population accumulates 9,0 hours/day of sedentary time. Overall, participants accumulated most sedentary time while watching television (2.2 hours/day) followed by sitting at work and other activities (both 1.7 hour/day). Significant differences (p > 0.001) were found by sex, age group and level of education. Men reported slightly more sedentary hours than women (9.2 vs. 8.8 hours/day). With respect to age groups, adolescents (12-17 years old) reported the highest, whereas children (4-11 years old) reported the lowest sedentary hours (10.1 vs. 7.3 hours/day). Finally, sedentary hours were high for higher educated people (9.7 vs. 8.2 hours/day in lower educated people). Adolescents accumulated most sedentary time at school or during studying (4.0 hours/day), higher educated people accumulated most sedentary time at work (3.4 hours/day).

Conclusions

Our study showed that in general Dutch people spend a lot of time sedentarily, especially adolescents and higher educated people. Most sedentary times was spent while watching television, at school or during studying, and at work. Therefore interventions aiming to decrease sedentary behaviour in the home environment, the occupational as well as the educational setting are of importance to implement.
P10-01 Acceptability of videoconferencing physical activity intervention among elderly in rural areas: qualitative study
Authors: Hayotte Meggy , Thérouanne Pierre , Vuillemin Anne , Van Hoye Aurélie , d'Arripe-Longueville Fabienne , Seytor Laure-Anne
Published: August 2022

Background

Elderly's sustainable engagement in an active lifestyle is a complex phenomenon, implying a plurality of physical, psychological and environmental barriers and facilitators. One of the key factors limiting physical activity (PA) in rural area is the lack of accessibility to PA offers. The use of videoconferencing is a promising solution in terms of acceptability and efficiency to promote PA. However, the acceptability (initial stage of the technology adoption process) of the videoconferencing is still underexplored, as well as its role in promoting PA in rural areas. The purpose of this study was to explore, through the perceptions of the elderly and policymakers, the mechanisms of acceptability of the development of PA interventions using videoconferencing for elderly living in rural areas.

Methods

Elderly (n = 10) and policymakers (n = 12) from 11 different rural town of the South of France participated in the study. Semi-structured individual interviews were conducted, where a video presentation of PA interventions using videoconferencing was played as support. The interview guide assessed the acceptability of this type of intervention through the following themes: (1) perceptions of benefits, (2) barriers, and (3) intentions of use.

Results

Preliminary results showed shared perceptions between elderly and policymakers for barriers (e.g., lack of real social ties, lack of technological equipment) and benefits (e.g., breaking loneliness, overcome weather conditions). However, intentions of use are heterogeneous according to individual characteristics (e.g., “young” elderly between 60 to 65 years are more favourable to the use of technologies) and the specificity of towns (e.g., in the smallest towns with less than 500 people, elderly are less inclined to change their habits).

Conclusions

This study showed that the development of videoconferencing PA intervention could be accepted by elderly living in rural areas, taking into account some conditions (e.g., offer as punctual and non-regular use, set up individual support for the use of technology). Additional quantitative studies should be conducted for a more comprehensive understanding of the factors influencing the videoconferencing PA intervention acceptability in rural areas.
P10-03 Developing online health community platform for enhancing physical activity in the community
Authors: Park Myonghwa , Jung Jihye , Kim Jahyeon , Kim Jinju
Published: August 2022

Virtual communities are emerging in many aspects of health activities and widespread in health management. Online health communities offer a virtual system where people with common interest, specific health needs can exchange information and experiences with other people with the same condition as well as getting support from peer and professionals. The objective of this study is to develop an ICT platform enhancing community resident participation involving in the chronic disease prevention and physical activities. The aim of this platform is to promote physical activity of community residents for health promotion and disease prevention goal attainment. Health promotion goals for enhancing physical activity were set by health care professionals based on scientific evidence. Instead of individual plan to set the goal by themselves, the platform offered them tailored goal with their conditions and then suggested them to participate in group shared their physical activity goals. The platform encouraged the active participation of community residents though adherence physical activity of health communities in which they were members.The ICT platform provides a place where community residents with chronic conditions or even healthy people who want to promote their health be able to find an appropriate group for together prevent disease and enhancing physical activity. The platform in the study allowed community residents to develop their own communities and invite other members to participate with them. This online community intended to empower community residents to increase their involvement in their self-management and pushing the active participation in phycial activities. Function such as reminder of activity participating was added. Future study will be conducted to evaluate changes in health promotion self-efficacy, health goal fulfillment, health-related quality of life, and shared decision-making after using the Health Community Platform among community residents. Extensive research initiatives are needed to determine the impact of virtual health communities on patient outcome, the overall process as well as quality and access of care.
P10-10 Technology-supported exercise may increase self-reported health status in people with residual movement impairments after neurological event
Authors: Graf Eveline , De Bon Dino , Zutter Daniel , Wirz Markus
Published: August 2022

Background

After a neurological event (e.g. stroke) people are often restricted to a sedentary lifestyle due to chronic impairment. Their need for assistance to perform any form of physical activity (PA) is one factor that limits their PA and results in a negative impact on health. Rehabilitation technology, designed for gait rehabilitation during sub-acute rehabilitation, may be used to achieve the recommended levels of PA in people with gait impairments. However, it is unknown if there are effects on the quality of life resulting from such exercise regimen. Therefore, the aim of this study was to determine the effect of technology-supported exercise (TSE) on self-reported health status.

Methods

Twelve people with severe residual gait impairment after a neurological event participated in the study. They performed TSE (with Lokomat, Andago or C-Mill) for three months (M3) with a minimum of 10 trainings per month. At baseline and M3, the following questionnaires were answered: EQ-5D-3L, WHODAS 2.0, patient global impression of scale (PGIC, only at M3). Wilcoxon-signed-rank-test was used to test for statistically significant differences between start and M3 (p > 0.05).

Results

The median EQ-5D Visual Analog Scale (VAS) score at baseline was 60, which is lower than the population mean. The VAS of the EQ-5D showed significant improvements (median: 7.5 points). The median of the PGIC was ‘minimally improved’ while all other outcomes (EQ-5D domains and WHODAS) remained constant.

Conclusion

Prior to TSE, the self-rated health status was low. There is evidence, that people with residual gait impairment may benefit from continuous TSE by improving health status, as has been represented by the improvement of the EQ-5D VAS score. Most chosen questionnaires may not be sensitive enough to detect subtle changes, indicating that for this population more sensitive instruments may be needed. However, future research investigating the sensitivity of the questionnaires is advisable. In addition, the training period of three months might be too short to be effective. This study is still ongoing with the training period extended to six months and additional participants included which will provide more data about the effect of TSE on self-reported health status.
Entre conseil et imposition ou comment le locuteur joue le jeu de son attitude: Étude du marqueur
je vais te dire une bonne chose
Authors: Álvarez-Castro Camino
Published: August 2022

French linguistics has recently paid close attention to discourse markers containing the verb
dire
, in line with the increased interest in discourse markers over the last few decades. At the heart of this debate are several intersecting and topical questions, among them: consideration of the speaker’s attitude within the semantic/pragmatic value of the marker, its dialogic function, and its level of fixedness. This study aims to examine the French discourse marker
je vais te dire une bonne chose
from this perspective, a phrase that purports to announce something that is not as good as it seems, in which the speaker plays a role halfway between advice-giving and imposition. The objective of this article is not only to uncover the discourse and interactional mechanisms governing the use of the phrase, but also to respond to criticism accusing some studies in semantics for their lack of operational criteria that could provide predictive and reproducible models. The analysis will be carried out through the identification of stable linguistic characteristics that can be identified by reproducible criteria. The study will be based on examples taken from Frantext and Sketch Engine, as well as personal readings and examples coined for the purposes of the discussion.
Nicotinamide Mononucleotide Alleviates Osteoblast Senescence Induction and Promotes Bone Healing in Osteoporotic Mice
Authors: Lu ZuFu , Jiang Liting , Lesani Pooria , Zhang WenJie , Li Ning , Luo Danyang , Li Yusi , Ye Yulin , Bian Ji , Wang Guocheng , Dunstan Colin R , Jiang XinQuan , Zreiqat Hala
Published: August 2022

Combating the accumulated senescent cells and the healing of osteoporotic bone fractures in the older remains a significant challenge. Nicotinamide mononucleotide (NMN), a precursor of NAD+, is an excellent candidate for mitigating aging-related disorders. However, it is unknown if NMN can alleviate senescent cell induction and enhance osteoporotic bone fracture healing. Here we show that NMN treatment partially reverses the effects of tumor necrosis factor-alpha (TNF-α) on human primary osteoblasts (HOBs): senescent cell induction, diminished osteogenic differentiation ability, and intracellular NAD+ and NADH levels. Mechanistically, NMN restores the mitochondrial dysfunction in HOBs induced by TNF-α evidenced by increased mitochondrial membrane potential and reduced reactive oxidative species and mitochondrial mass. NMN also increases mitophagy activity by down-regulating P62 expression and up-regulating light chain 3B-II protein expression. In addition, the cell senescence protective effects of NMN on HOBs are mitigated by a mitophagy inhibitor (Bafilomycin A1). In vivo, NMN supplementation attenuates senescent cell induction in growth plates, partially prevents osteoporosis in an ovariectomized mouse model, and accelerates bone healing in osteoporotic mice. We conclude that NMN can be a novel and promising therapeutic candidate to enhance bone fracture healing capacity in the older.
Chronic Care for All? The Intersecting Roles of Race and Immigration in Shaping Multimorbidity, Primary Care Coordination, and Unmet Health Care Needs Among Older Canadians
Authors: Lin Shen (Lamson) , Fang Lin
Published: August 2022

Objectives

Despite the predominance of chronic disease clustering, primary care delivery for multimorbid patients tends to be less effective and often uncoordinated. This study aims to quantify racial–nativity inequalities in multimorbidity prevalence ≥3 chronic conditions), access to primary care, and relations to past-year subjective unmet health care needs (SUN) among older Canadians.

Methods

Population-based data were drawn from the Canadian Community Health Survey (2015–2018). Multivariable logistic regression was performed to estimate the likelihood of multimorbidity, sites of usual source of primary care (USOC), primary care coordination, and multidimensional aspects of SUN. The Classification and Regression Tree (CART) was applied to identify intersecting determinants of SUN.

Results

The overall sample (n = 19,020) were predominantly (69.4%) Canadian-born (CB) Whites (1% CB non-Whites, 18.1% White immigrants, and 11.5% racialized immigrants). Compared with CB Whites, racialized immigrants were more likely to have multimorbidity (adjusted odds ratio [AOR] = 1.35, 99% confidence interval [CI]: 1.13–1.61), lack a USOC (AOR = 1.41, 99% CI: 1.07–1.84), and report higher SUN (AOR = 1.47, 99% CI: 1.02–2.11). Racialized immigrants’ greater SUN was driven by heightened affordability barriers (AOR = 4.31, 99% CI: 2.02–9.16), acceptability barriers (AOR = 3.11, 99% CI: 1.90–5.10), and unmet needs for chronic care (AOR = 2.71, 99% CI: 1.53–4.80) than CB Whites. The CART analysis found that the racial–nativity gap in SUN perception was still evident even among those who had access to nonpoorly coordinated care.

Discussion

To achieve an equitable chronic care system, efforts need to tackle affordability barriers, improve service acceptability, minimize service fragmentation, and reallocate treatment resources to underserved older racialized immigrants in Canada.
An Opioid Hiding in Plain Sight: Loperamide-Induced False-Positive Fentanyl and Buprenorphine Immunoassay Results
Authors: Geno K Aaron , Badea Adina , Lynch Kara L , Jannetto Paul , Hubbard Jacqueline A , Nerenz Robert D , Cervinski Mark A
Published: August 2022

Background

Loperamide (Imodium®), a commonly used anti-diarrheal, is a mu opioid receptor agonist that, like all opioids, reduces gastrointestinal tract peristalsis. Loperamide is considered to have low abuse potential as it does not produce an analgesic or euphoric effect due to low bioavailability and first-pass metabolism. However, reports of individuals misusing loperamide through the use of super-therapeutic doses, alone or in combination with P-glycoprotein and/or CYP450 enzyme inhibitors, is increasing. We hypothesized that loperamide could potentially cross-react with laboratory immunoassay drug screens.

Methods

Drug-free urine was spiked with loperamide or its principal metabolite, N-desmethyl loperamide (dLop), and assayed on multiple fentanyl and buprenorphine assays. Fentanyl immunoassay screen-positive results at one institution were examined by high-resolution mass spectrometry (MS) for the presence of loperamide and quantified by liquid chromatography– tandem MS when positive.

Results

Loperamide produced positive results on the Thermo DRI Fentanyl and Immunalysis Fentanyl assays at concentrations greater than 5.72 mg/L and 23.7 mg/L. dLop generated positive results for the Thermo DRI and Immunalysis fentanyl assays at concentrations exceeding 6.9 mg/L and 35.7 mg/L. dLop also produced positive buprenorphine results on the Thermo CEDIA buprenorphine assay at concentrations exceeding 12.2 mg/L. High-resolution MS analysis of 225 fentanyl immunoassay positives (Thermo DRI) yielded 5 specimens containing loperamide and/or dLop, 4 of which contained measurable quantities of fentanyl in addition to loperamide/dLop.

Conclusions

Laboratories using these assays should be aware of the potential for false-positive screening results due to the presence of high concentrations of loperamide and its metabolite dLop.
Performance of Hair  Testing for Cocaine Use—Comparison of Five Laboratories Using Blind Reference Specimens
Authors: Hart E Dale , Vikingsson Svante , Winecker Ruth E , Evans Amy L , Cone Edward J , Mitchell John M , Hayes Eugene D , Flegel Ronald R
Published: August 2022

The purpose of this study was to compare results from five commercial hair testing laboratories conducting workplace drug testing with regard to bias, precision, selectivity and decontamination efficiency. Nine blind hair specimens, including cocaine-positive drug user specimens (some contaminated with methamphetamine) and negative specimens contaminated with cocaine, were submitted in up to five replicates to five different laboratories. All laboratories correctly identified cocaine in all specimens from drug users. For an undamaged hair specimen from a cocaine user, within-laboratory Coefficients of Variation (CVs) of 5–22% (median 8%) were reported, showing that it is possible to produce a homogenous proficiency testing sample from drug user hair. Larger CVs were reported for specimens composed of blended hair (up to 29%) and curly/damaged hair (19–67%). Quantitative results appeared to be method-dependent, and the reported cocaine concentrations varied up to 5-fold between the laboratories, making interlaboratory comparisons difficult. All laboratories reported at least one positive result in specimens contaminated with cocaine powder, followed by sweat and shampoo treatments. Benzoylecgonine, norcocaine, cocaethylene and hydroxylated cocaine metabolites were all detected in cocaine powder-contaminated specimens. This indicates that current industry standards for analyzing and reporting positive cocaine results are not completely effective at identifying external contamination. Metabolite ratios between meta- or para-hydroxy-cocaine and cocaine were 6- and 10-fold lower in contaminated specimens compared to those observed in cocaine user specimens, supporting their potential use in distinguishing samples positive due to contamination and drug use.
Mode confusion of human–machine interfaces for automated vehicles
Authors: Eom Hwisoo , Lee Sang Hun
Published: August 2022

In this study, we designed two user interfaces for automated vehicles operated in the modes that correspond to the Society of Automotive Engineers automation levels 0–3. The first is a level-centred interface that allows the driver to increase or decrease the automation level step-by-step. The second is a function-centred interface that has independent driving controls in the longitudinal and lateral directions. We implemented prototypes for the two interfaces and conducted driver-in-the-loop experiments on a driving simulator to verify their effectiveness in the driver’s mode awareness. For events on the road, the participants took actions to control the vehicle, which might cause mode changes, and answered the modes he/she believed. The experimental results show that the mode confusion rate of the level-centred interface is twice higher than that of the function-centred interface. Also, visual feedbacks can reduce the mode confusion rate dramatically. The results show that a function-centred user interface combined with adequate visual and/or auditory feedback is essential to improve driver’s mode awareness when driving an automated vehicle.
Augmented deep learning workflow for robust fault prediction over multiple tectonic regimes
Authors: Chen Haidong , Tang Dazhen , Liu Ying , Gu Hongtao , Zhou Cunjian
Published: August 2022

Over the past decade, deep learning frameworks such as convolutional neural networks (CNNs) have made major research inroads in upstream oil and gas, with applications in seismic processing/imaging, velocity model building, petrophysics, geological seismic interpretation, all the way to development, production and supply chain logistics. CNN fault prediction centers around the idea of image edge detection and, for improved prediction results, three data-driven steps are recommended. First, pre-condition the seismic data to increase signal-to-noise ratio as much as possible: iterative dip-steered median filtering and principal component filtering are adopted to further improve signal-to-noise ratio and sharpness for edge detection. Second, a fault probability volume obtained through deep learning (DL) -based fault detection using a U-Net architecture, taking synthetic seismic models as samples that can improve DL-based fault prediction in lieu of readily available labeled fault sets that may be prohibitively time-consuming to generate. Finally, edge enhancement is performed on the inference results to improve precision and fault continuity. A comparative analysis between related edge enhancement technologies is also presented. Results for three different faulting modes (normal, reverse and strike-slip) over three real seismic field data sets from China demonstrate the robustness of the proposed workflow.