bluuebunny/crossref_metadata_2025 huggingface dataset:
Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells
Authors: Kong Yuanyuan , Chen Gege , Xu Zhijian , Yang Guang , Li Bo , Wu Xiaosong , Xiao Wenqin , Xie Bingqian , Hu Liangning , Sun Xi , Chang Gaomei , Gao Minjie , Gao Lu , Dai Bojie , Tao Yi , Zhu Weiliang , Shi Jumei
Published: November 2016

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo. We found that pterostilbene treatment resulted in a dose-dependent inhibition of cell viability. In addition, pterostilbene exhibited a strong cytotoxic effect, as evidenced not only by reductions of mitochondrial membrane potential (MMP) but also by increases in cellular apoptotic index and reactive oxygen species (ROS) levels, leading to arrest in the S-phase of the cell cycle. Furthermore, pterostilbene treatment directly up-regulated p-p38MAPK and down-regulated p-ERK1/2. In vivo, intravenous administration of pterostilbene inhibited tumor development in xenograft mouse models. Overall, the results suggested that pterostilbene is a potential anti-cancer pharmaceutical against human DLBCL by a mechanism involving the suppression of ERK1/2 and activation of p38MAPK signaling pathways.
Fundamental Scaling Laws in Nanophotonics
Authors: Liu Ke , Sun Shuai , Majumdar Arka , Sorger Volker J.
Published: November 2016

The success of information technology has clearly demonstrated that miniaturization often leads to unprecedented performance, and unanticipated applications. This hypothesis of “smaller-is-better” has motivated optical engineers to build various nanophotonic devices, although an understanding leading to fundamental scaling behavior for this new class of devices is missing. Here we analyze scaling laws for optoelectronic devices operating at micro and nanometer length-scale. We show that optoelectronic device performance scales non-monotonically with device length due to the various device tradeoffs, and analyze how both optical and electrical constrains influence device power consumption and operating speed. Specifically, we investigate the direct influence of scaling on the performance of four classes of photonic devices, namely laser sources, electro-optic modulators, photodetectors, and all-optical switches based on three types of optical resonators; microring, Fabry-Perot cavity, and plasmonic metal nanoparticle. Results show that while microrings and Fabry-Perot cavities can outperform plasmonic cavities at larger length-scales, they stop working when the device length drops below 100 nanometers, due to insufficient functionality such as feedback (laser), index-modulation (modulator), absorption (detector) or field density (optical switch). Our results provide a detailed understanding of the limits of nanophotonics, towards establishing an opto-electronics roadmap, akin to the International Technology Roadmap for Semiconductors.
Reversible strain control of magnetic anisotropy in magnetoelectric heterostructures at room temperature
Authors: Staruch Margo , Gopman Daniel B. , Iunin Yury L. , Shull Robert D. , Cheng Shu Fan , Bussmann Konrad , Finkel Peter
Published: November 2016

The ability to tune both magnetic and electric properties in magnetoelectric (ME) composite heterostructures is crucial for multiple transduction applications including energy harvesting or magnetic field sensing, or other transduction devices. While large ME coupling achieved through interfacial strain-induced rotation of magnetic anisotropy in magnetostrictive/piezoelectric multiferroic heterostructures has been demonstrated, there are presently certain restrictions for achieving a full control of magnetism in an extensive operational dynamic range, limiting practical realization of this effect. Here, we demonstrate the possibility of generating substantial reversible anisotropy changes through induced interfacial strains driven by applied electric fields in magnetostrictive thin films deposited on (0 1 1)-oriented domain-engineered ternary relaxor ferroelectric single crystals with extended temperature and voltage ranges as compared to binary relaxors. We show, through a combination of angular magnetization and magneto-optical domain imaging measurements, that a 90° in-plane rotation of the magnetic anisotropy and propagation of magnetic domains with low applied electric fields under zero electric field bias are realized. To our knowledge, the present value attained for converse magnetoelectric coupling coefficient is the highest achieved in the linear piezoelectric regime and expected to be stable for a wide temperature range, thus representing a step towards practical ME transduction devices.
The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens
Authors: Petrova Mariya I. , Lievens Elke , Verhoeven Tine L. A. , Macklaim Jean M. , Gloor Gregory , Schols Dominique , Vanderleyden Jos , Reid Gregor , Lebeer Sarah
Published: November 2016

The probiotic Lactobacillus rhamnosus GR-1 has been documented to survive implantation onto the vaginal epithelium and interfere with urogenital pathogens. However, the molecular mechanisms involved are largely unknown. Here, we report for the first time the construction of dedicated knock-out mutants in L. rhamnosus GR-1 to enable the study of gene functions. In a search for genes responsible for the adherence capacity of L. rhamnosus GR-1, a genomic region encoding a protein with homology to lectin-like proteins was identified. Phenotypic analyses of the knock-out mutant of L. rhamnosus GR-1 revealed a two-fold decreased adhesion to the vaginal and ectocervical epithelial cell lines compared to wild-type. In contrast, the adhesion to gastro-intestinal epithelial (Caco2) and endocervical cell lines (Hela and End1/E6E7) was not drastically affected by the mutation, suggesting that the LGR-1_Llp1 lectins mediates tissue tropism. The purified LGR-1_Llp1 protein also inhibited biofilm formation and adhesion of uropathogenic Escherichia coli. For the first time, an important role for a novel lectin-like protein in the adhesion capacity and host cell-specific interaction of a vaginal probiotic Lactobacillus strain has been discovered, with an additional role in pathogen inhibition.
Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans
Authors: Liu Liwei , Hao Tingting , Xie Zhoujie , Horsman Geoff P. , Chen Yihua
Published: November 2016

Streptococcus mutans is a major pathogen causing human dental caries. As a Gram-positive bacterium with a small genome (about 2 Mb) it is considered a poor source of natural products. Due to a recent explosion in genomic data available for S. mutans strains, we were motivated to explore the natural product production potential of this organism. Bioinformatic characterization of 169 publically available genomes of S. mutans from human dental caries revealed a surprisingly rich source of natural product biosynthetic gene clusters. Anti-SMASH analysis identified one nonribosomal peptide synthetase (NRPS) gene cluster, seven polyketide synthase (PKS) gene clusters and 136 hybrid PKS/NRPS gene clusters. In addition, 211 ribosomally synthesized and post-translationally modified peptides (RiPPs) clusters and 615 bacteriocin precursors were identified by a combined analysis using BAGEL and anti-SMASH. S. mutans harbors a rich and diverse natural product genetic capacity, which underscores the importance of probing the human microbiome and revisiting species that have traditionally been overlooked as “poor” sources of natural products.
Hypoxia-induced vasculogenic mimicry formation in human colorectal cancer cells: Involvement of HIF-1a, Claudin-4, and E-cadherin and Vimentin
Authors: Li Wen , Zong ShaoQi , Shi Qi , Li HongJia , Xu Jian , Hou Fenggang
Published: November 2016

Vasculogenic mimicry (VM) plays an important role in colorectal cancer (CRC) metastasis, and both hypoxia and the epithelial-mesenchymal transition (EMT) are necessary for VM. In this study, HIF-1α expression was upregulated in the VM-positive CRC cell line HCT-116 and thereby affected the expression of the EMT-related markers Claudin-4, E-cadherin (E-cd) and Vimentin(VIM). SB431542 and U0126EtOH, which can inhibit of EMT were used to treat HCT-116 and HCT-8 in these experiments. Both of the inhibitors had significant effect on EMT markers and the formations of VM in CRC cells. In addition, knockdown of HIF-1α in the HCT-116 cells inhibited their capacity for VM. Our study reveals a regulatory role for HIF-1α in VM and suggests that targeting either HIF-1α or EMT may be a valuable strategy for the elimination of CRC metastasis.
Interactions of the Greater Ontong Java mantle plume component with the Osbourn Trough
Authors: Zhang Guo-Liang , Li Chao
Published: November 2016

The Ontong Java-Manihiki-Hikurangi plateau (OJMHP) is considered to have originated from a starting mantle plume, and have been rifted apart by two spreading ridges. However, the ages of these spreading ridges and their possible interactions with the presumed mantle plume are unclear. The Manihiki-Hikurangi plateau has been rifted apart by the Osbourn Trough which formed the southwestern Pacific crust to the east of the Tonga-Kermadec trench. Here we report Pb-Hf-Os isotopes of the basaltic crust (Site U1365 of IODP Expedition 329) formed by the Osbourn Trough. Linear regression of Re-Os isotopes results in an age of 103.7 ± 2.3 Ma for Site U1365 basalts, indicating that the Manihiki-Hikurangi plateau was rifted apart by the Osbourn Trough with a spreading rate of ~190 mm/yr. The superfast spreading rate supports the Osbourn as an abandoned segment of the early Pacific spreading ridge, which initially overlapped with the giant starting plume. Moreover, the Pb-Hf isotopes of some of Site U1365 basalts show distinct differences from those of the Pacific mid-ocean ridge basalts, while they are similar to the basalts of the Ontong Java and Manihiki plateaus. We suggest that the OJMHP mantle plume components has been involved by the Osbourn spreading center.
Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice
Authors: Lim Lee Wei , Shrestha Smeeta , Or Yu Zuan , Tan Shawn Zheng Kai , Chung Hwa Hwa , Sun Yang , Lim Chew Leng , Khairuddin Sharafuddin , Lufkin Thomas , Lin Valerie Chun Ling
Published: November 2016

Tetratricopeptide repeat domain 9A (TTC9A) expression is abundantly expressed in the brain. Previous studies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A negatively regulates the action of estrogen. In this study we investigated the role of TTC9A on anxiety-like behavior through its functional interaction with estrogen using the TTC9A−/− mice model. A battery of tests on anxiety-related behaviors was conducted. Our results demonstrated that TTC9A−/− mice exhibited an increase in anxiety-like behaviors compared to the wild type TTC9A+/+ mice. This difference was abolished after ovariectomy, and administration of 17-β-estradiol benzoate (EB) restored this escalated anxiety-like behavior in TTC9A−/− mice. Since serotonin is well-known to be the key neuromodulator involved in anxiety behaviors, the mRNA levels of tryptophan hydroxylase (TPH) 1, TPH2 (both are involved in serotonin synthesis), and serotonin transporter (5-HTT) were measured in the ventromedial prefrontal cortex (vmPFC) and dorsal raphe nucleus (DRN). Interestingly, the heightened anxiety in TTC9A−/− mice under EB influence is consistent with a greater induction of TPH 2, and 5-HTT by EB in DRN that play key roles in emotion regulation. In conclusion, our data indicate that TTC9A modulates the anxiety-related behaviors through modulation of estrogen action on the serotonergic system in the DRN.
Noisy galvanic vestibular stimulation induces a sustained improvement in body balance in elderly adults
Authors: Fujimoto Chisato , Yamamoto Yoshiharu , Kamogashira Teru , Kinoshita Makoto , Egami Naoya , Uemura Yukari , Togo Fumiharu , Yamasoba Tatsuya , Iwasaki Shinichi
Published: November 2016

Vestibular dysfunction causes postural instability, which is prevalent in the elderly. We previously showed that an imperceptible level of noisy galvanic vestibular stimulation (nGVS) can improve postural stability in patients with bilateral vestibulopathy during the stimulus, presumably by enhancing vestibular information processing. In this study, we investigated the after-effects of an imperceptible long-duration nGVS on body balance in elderly adults. Thirty elderly participants underwent two nGVS sessions in a randomised order. In Session 1, participants received nGVS for 30 min twice with a 4-h interval. In Session 2, participants received nGVS for 3 h. Two-legged stance tasks were performed with eyes closed while participants stood on a foam rubber surface, with and without nGVS, and parameters related to postural stability were measured using posturography. In both sessions, the postural stability was markedly improved for more than 2 h after the cessation of the stimulus and tended to decrease thereafter. The second stimulation in Session 1 caused a moderate additional improvement in body balance and promoted the sustainability of the improvement. These results suggest that nGVS can lead to a postural stability improvement in elderly adults that lasts for several hours after the cessation of the stimulus, probably via vestibular neuroplasticity.
A highly efficient, stable, durable, and recyclable filter fabricated by femtosecond laser drilling of a titanium foil for oil-water separation
Authors: Ye Sen , Cao Qiang , Wang Qingsong , Wang Tianyuan , Peng Qing
Published: November 2016

It has been a long standing challenge to efficiently separate oil and water since prehistoric times, and now it has become even more desirable in oily wastewater purification and oil spill cleanup. Here we introduce a super oil–water separation filter with superhydrophilicity and underwater superoleophobicity, fabricated using femtosecond laser micro-hole drilling of a titanium foil. Such a simply-made filter, without any modification, can achieve a separation efficiency exceeding 99% in eight typical oil–water mixtures. It remains highly efficient after 40 cycles of recycling and after suffering erosion by corrosive media. Furthermore, the used filter, polluted with oil, could be recovered by ultraviolet illumination. The flux of filtered water is tunable by simply selecting the aperture of the microhole or the spacing between adjacent microholes. Such advanced functionality is due to roughness and the TiO2 layers on the ablated surface during fabrication. With superhydrophilic and superoleophobic surfaces, this oil-water filer is also suitable for applications in anti-fouling, anti-smudge, anti-fog, and self-cleaning.
The effects of non-self-sustained oscillators on the en-trainment ability of the suprachiasmatic nucleus
Authors: Gu Changgui , Tang Ming , Rohling Jos H. T. , Yang Huijie
Published: November 2016

In mammals, the circadian rhythms of behavioral and physiological activities are regulated by an endogenous clock located in the suprachiasmatic nucleus (SCN). The SCN is composed of ~20,000 neurons, of which some are capable of self-sustained oscillations, while the others do not oscillate in a self-sustainable manner, but show arrhythmic patterns or damped oscillations. Thus far, the effects of these non-self-sustained oscillatory neurons are not fully explored. Here, we examined how the proportion of the non-self-sustained oscillators affects the free running period under constant darkness and the ability to entrain to the light-dark cycle. We find that the proportion does not affect the free running period, but plays a significant role in the range of entrainment. We also find that its effect on the entrainment range depends on the region where the non-self-sustained oscillators are located. If the non-self-sustained oscillatory neurons are situated in the light-sensitive subregion, the entrainment range narrows when the proportion increases. If they are situated in the light-insensitive subregion, however, the entrainment range broadens with the increase of the proportion. We suggest that the heterogeneity within the light-sensitive and light-insensitive subregions of the SCN has important consequences for how the clock works.
A novel miniaturized biofilter based on silicon micropillars for nucleic acid extraction
Authors: Petralia Salvatore , Sciuto Emanuele Luigi , Conoci Sabrina
Published: November 2016

New miniaturised microfluidic biofilter (BF) devices based on silicon micropillars have been developed and tested regarding their ability to extract HBV (Hepatitis B Virus) bacterial DNA from biological sample solutions.
Thin layered drawing media probed by THz time-domain spectroscopy
Authors: Tasseva J. , Taschin A. , Bartolini P. , Striova J. , Fontana R. , Torre R.
Published: November 2016

Dry and wet drawing materials were investigated by THz time-domain spectroscopy in transmission mode.
A kanamycin sensor based on an electrosynthesized molecularly imprinted poly-o-phenylenediamine film on a single-walled carbon nanohorn modified glassy carbon electrode
Authors: Han Shuang , Li Bingqian , Song Ze , Pan Sihao , Zhang Zhichao , Yao Hui , Zhu Shuyun , Xu Guobao
Published: November 2016

The application of a single-walled carbon nanohorn for a molecularly imprinted sensor has been demonstrated for the first time.
A diagnostic test for cocaine and benzoylecgonine in urine and oral fluid using portable mass spectrometry
Authors: Ismail Mahado , Baumert Mark , Stevenson Derek , Watts John , Webb Roger , Costa Catia , Robinson Fiona , Bailey Melanie
Published: November 2016

Surface mass spectrometry methods can be difficult to use effectively with low cost, portable mass spectrometers.
An amperometric FIA system with carrier recycling: an environmentally friendly approach for atenolol determination in pharmaceutical formulations
Authors: Franco M. A. , Araújo D. A. G. , Oliveira L. H. , Trindade M. A. G. , Takeuchi R. M. , Santos A. L.
Published: November 2016

Carrier solution recirculation in an amperometric FIA system allows ATN quantification with very low reagent consumption and waste generation.
High MOF loading in mixed-matrix membranes utilizing styrene/butadiene copolymers
Authors: Moreton Jessica C. , Denny Michael S. , Cohen Seth M.
Published: November 2016

Combining metal–organic frameworks with styrene-based polymer binders yields new mixed-matrix membranes with good mechanical and physical properties.
One-step fabrication of porous oxygen-doped g-C3N4with feeble nitrogen vacancies for enhanced photocatalytic performance
Authors: Fang Li Jun , Wang Xue Lu , Zhao Jun Jie , Li Yu Hang , Wang Yu Lei , Du Xu Lei , He Zhi Fei , Zeng Hui Dan , Yang Hua Gui
Published: November 2016

Porous oxygen-doped g-C3N4with feeble nitrogen vacancies was fabricatedviaa one-step method to enhance its photocatalytic performance.
Solution-phase synthesis of 1D tubular polymers via preorganization–polymerization
Authors: Yu Hao , Häner Robert
Published: November 2016

Tubular polymers are synthesized by a preorganization–polymerization method in aqueous medium.
Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source
Authors: Sanz Sharley Daniel D. , Williams Jonathan M. J.
Published: November 2016

Amides are prepared in good from amines using catalytic acetic acid and ester as the acyl source.
Magnetic coupling in a hybrid Mn(ii) acetylene dicarboxylate
Authors: Hendon Christopher H. , Pradaux-Caggiano Fabienne , Hatcher Lauren E. , Gee William J. , Wilson Chick C. , Butler Keith T. , Carbery David R. , Walsh Aron , Melot Brent C.
Published: November 2016

The design of ligands that mediate through-bond long range super-exchange in metal–organic hybrid materials would expand chemical space beyond the commonly observed short range, low temperature magnetic ordering.
Highly active and selective binary MgO–SiO2 catalysts for the production of 1,3-butadiene from ethanol
Authors: Huang Xiaoxiong , Men Yong , Wang Jinguo , An Wei , Wang Yuanqiang
Published: November 2016

Wet-kneaded binary MgO–SiO2 composite catalysts gave exceptionally high productivity of butadiene governed by a subtle balance of acid–base sites in relation to the formation of an interfacial Si–O–Mg linkage and by varying preparation methods and MgO to SiO2 ratios.
Recovery of uranium(vi) from aqueous solutions using a modified honeycomb-like porous carbon material
Authors: Zhu Jiahui , Liu Qi , Li Zhanshuang , Liu Jingyuan , Zhang Hongsen , Li Rumin , Wang Jun , Emelchenko G. A.
Published: November 2016

A novel composite adsorbent, consisting of three-dimensional honeycomb-like porous carbon and MnO2 nanowires (HLPC/MnO2), has been successfully synthesized and is an excellent adsorbent for removing uranium(vi) ions from aqueous solutions.
Luminescent rare-earth-based MOFs as optical sensors
Authors: Mahata Partha , Mondal Sudip Kumar , Singha Debal Kanti , Majee Prakash
Published: November 2016

This perspective article highlights the basics and applications of luminescence-based sensing of hazardous chemicals, pH, and temperature using rare-earth-based metal–organic frameworks.
Tantalum isotope ratio measurements and isotope abundances determined by MC-ICP-MS using amplifiers equipped with 1010, 1012and 1013Ohm resistors
Authors: Pfeifer M. , Lloyd N. S. , Peters S. T. M. , Wombacher F. , Elfers B.-M. , Schulz T. , Münker C.
Published: November 2016

We revise the tantalum isotope composition and present a protocol to search for anomalies in geological and extraterrestrial materials.
An ionic liquid promoted approach to bitriazolyl compounds as succinate–ubiquinone oxidoreductase inhibitors
Authors: Zhang Rui , Wu Qiong-You , Tao Jun , Pan Jin-Huan , Yang Guang-Fu
Published: November 2016

Bitriazolyl compounds, a novel skeleton that is totally different from existing commercialized SQR-inhibiting fungicides, could provide a new lead for further development of SQR inhibitors.
A simple method for preparation of a novel hydrophobic ionic liquid with a per-fluoro-tert-butoxide anion
Authors: Kurnia Kiki A. , Sintra Tânia E. , Danten Yann , Cabaço Maria Isabel , Besnard Marcel , Coutinho João A. P.
Published: November 2016

A simple and atom-economic method for preparation of a novel hydrophobic ionic liquid based on the per-fluoro-tert-butoxide anion.
Dual-affinity peptide mediated inter-protein recognition
Authors: Duan Hongyang , Zhu Ling , Hou Jingfei , Peng Jiaxi , Xie Hanyi , Lin Yuchen , Liu Changliang , Li Wenzhe , Xu Haiyan , Wang Chen , Yang Yanlian
Published: November 2016

A dual-affinity peptide E5 mediated enhanced interaction affinity between human serum albumin (HSA) and a membrane protein (chemokine receptor CXCR4).
Viability of dodecahedrane-forming radical polycyclizations
Authors: Wang Selina C. , Tantillo Dean J.
Published: November 2016

The results of density functional theory calculations on thiyl radical-promoted polycyclization to form dodecahedrane are described.
A self-assembled peptide mimetic of a tubular host and a supramolecular polymer
Authors: Paikar Arpita , Pramanik Apurba , Das Tanmay , Haldar Debasish
Published: November 2016

A tripeptide self-assembles in a helical manner to form a tubular host-like supramolecular nanotube. The tube with a hydrophobic core has been used to develop a supramolecular polymer.
Structures, formation mechanisms, and ion-exchange properties of α-, β-, and γ-Na2TiO3
Authors: Meng Fancheng , Liu Yahui , Xue Tianyan , Su Qian , Wang Weijing , Qi Tao
Published: November 2016

The structure of β-Na2TiO3 was refined. The formation/transformation mechanisms and ion-exchange properties of α-, β-, and γ-Na2TiO3 were investigated.
Simple phase transfer of nanoparticles from aqueous to organic media using polymer colloids as carriers
Authors: Sapoletova Nina A. , Kushnir Sergey E. , Kushnir Alexey E. , Kocherginskaya Polina B. , Kazin Pavel E. , Napolskii Kirill S.
Published: November 2016

A simple and versatile method of the phase transfer of nanoparticles from aqueous to organic media using charged polymer colloids as carriers is proposed.
Sn/carbon nanofibers fabricated by electrospinning with enhanced lithium storage capabilities
Authors: Zhao Shuping , Yang Zhenglong , Jiang Wei , Kang Liying , Liu Na , Meng Yanfeng , Sun Changmei
Published: November 2016

Well dispersed Sn nanoparticles/carbon nanofibers with enhanced lithium storage capabilities were fabricated by electrospinning.
Investigation of the effect of VOx/ZrO2 structure on the catalytic activity in cyclohexene epoxidation
Authors: El-Korso Sanaa , Bedrane Sumeya , Choukchou-Braham Abderrahim , Bachir Redouane
Published: November 2016

The coexistence of a solid solution with polymeric vanadium species in the case of 5VZr-2 and with the formation of ZrV2O7 in the case of 5VZr-3, resulted in good catalytic performance, with up to 80% epoxide selectivity and 32% cyclohexene conversion.
Facile synthesis of hair-extract-capped gold and silver nanoparticles and their biological applications
Authors: Rohullah Rohullah , Azam Andaleeb , Qiao Shanlin , Islam Mazhar Ul , Ali Javed , Wahab Abdul , Khan Murad Ali , Farhan Farhan , Hameed Abdul
Published: November 2016

Hair is a waste keratinous biomaterial.
Silver nanoparticles functionalized with a fluorescent cyclic RGD peptide: a versatile integrin targeting platform for cells and bacteria
Authors: Di Pietro P. , Zaccaro L. , Comegna D. , Del Gatto A. , Saviano M. , Snyders R. , Cossement D. , Satriano C. , Rizzarelli Enrico
Published: November 2016

A green fluorescent RGD peptide–silver nanoparticle platform to target integrin receptors in cells and bacterial studies.
Nano-topographic titanium modulates macrophage response in vitro and in an implant-associated rat infection model
Authors: Tan Jing , Zhao Chanjuan , Wang Yi , Li Yiting , Duan Ke , Wang Jianxin , Weng Jie , Feng Bo
Published: November 2016

Nano-structured titanium in an infection environment can effectively regulate the inflammatory response and promote the tissue remodeling within initial implantation.
Solvent free oxidative coupling polymerization of 3-hexylthiophene (3HT) in the presence of FeCl3 particles
Authors: Hirai T. , Nagae Y. , White K. L. , Kamitani K. , Kido M. , Uchiyama T. , Nishibori M. , Konishi Y. , Yokomachi K. , Sugimoto R. , Saigo K. , Ohishi T. , Higaki Y. , Kojio K. , Takahara A.
Published: November 2016

Solvent free oxidative coupling reaction of 3HT within a nanocavity is demonstrated. The side reaction at the 4-position is regulated.
Preventive effects of zingerone on cardiac mitochondrial oxidative stress, calcium ion overload and adenosine triphosphate depletion in isoproterenol induced myocardial infarcted rats
Authors: Hemalatha Kunchpillai Lakshmanan , Mainzen Prince Ponnian Stanely
Published: November 2016

Cardiac mitochondrial oxidative stress, calcium ion (Ca2+) overload and adenosine triphosphate (ATP) depletion play an important role in the pathogenesis of myocardial infarction.
Synthesis of amine-polyglycidol functionalised Fe3O4@SiO2nanocomposites for magnetic hyperthermia, pH-responsive drug delivery, and bioimaging applications
Authors: Moorthy Madhappan Santha , Oh Yunok , Bharathiraja Subramanian , Manivasagan Panchanathan , Rajarathinam Thenmozhi , Jang Bian , Vy Phan Thi Tuong , Jang Hyukjin , Oh Junghwan
Published: November 2016

We report the biocompatible Fe3O4@SiO2@APG-F nanocomposite for drug delivery and hyperthermia applications. The Fe3O4@SiO2@APG-F nanocomposite could serve as a good hyperthermia agent, drug delivery carrier, and fluorescent contrast agent.
Performance and mass transfer of aqueous fluoride removal by a magnetic alumina aerogel
Authors: Yang Wen , Dou Xiaomin , Li Yonghuan , Mohan Dinesh , Pittman Charles U. , Ok Yong Sik
Published: November 2016

A novel magnetic alumina aerogel was evaluated for F− removal from water. It is an effective and easily prepared adsorbent with moderate cost that operates in a magnetic separation-enhanced sequencing batch mode which fully benefits from the fast kinetics of fine powders.
An integrated salinity-driven workflow for rapid lipid enhancement in green microalgae for biodiesel application
Authors: Satpati Gour Gopal , Chandra Gorain Prakash , Paul Ishita , Pal Ruma
Published: November 2016

A laboratory based integrated approach was undertaken for improvement of lipid accumulation in green microalgae under sodium chloride (NaCl) stress.
A modified homogeneous surface diffusion model for the fixed-bed adsorption of 4,6-DMDBT on Ag–CeOx/TiO2–SiO2
Authors: Zheng Meiqin , Xu Chengzhi , Hu Hui , Ye Zhuoliang , Chen Xiaohui
Published: November 2016

The adsorption of 4,6-dimethyldibenzothiophene (4,6-DMDBT) from diesel fuel using a fixed bed column was investigated.
A resistive-type humidity sensor based on polypyrrole and ZnO nanoparticles: hybrid polymers vis-a-vis nanocomposites
Authors: Najjar Reza , Nematdoust Samira
Published: November 2016

Humidity sensors based on ZnO–polypyrrole hybrid polymers indicated a better performance than ZnO–polypyrrole nanocomposite based sensors.
Au–cysteine modified macroporous adsorption resin: preparation and highly selective enrichment and identification of N-linked glycopeptides from the complex biological sample
Authors: Sun Xudong , Dong Jing , Li Jinan , Ye Mingliang , Ou Junjie , Zhang Lingyi , Zhang Weibing
Published: November 2016

Cysteine functionalized macroporous adsorption resin/gold nanoparticle was synthesized and applied to the highly selective enrichment and identification of N-linked glycopeptides.
Multispectroscopic analysis and molecular modeling to investigate the binding of beta lactoglobulin with curcumin derivatives
Authors: Maity Sanhita , Pal Sampa , Sardar Subrata , Sepay Nayim , Parvej Hasan , Chakraborty Jishnu , Chandra Halder Umesh
Published: November 2016

Bovine beta lactoglobulin (β-lg), the major whey protein, has a great affinity for a wide range of organic compounds like fatty acids, retinoletc.
Nanostructured surfaces of biodegradable silica fibers enhance directed amoeboid cell migration in a microtubule-dependent process
Authors: Emmert Martin , Witzel Patrick , Rothenburger-Glaubitt Miranda , Heinrich Doris
Published: November 2016

This study reveals significantly enhanced amoeboid cell migration on biodegradable silica fibers in comparison to plain glass surfaces.
Transition metal-free cross-dehydrogenative coupling acylation of coumarins by the K2S2O8/Aliquat 336 catalytic system: a versatile strategy towards 4-aroylcoumarin derivatives
Authors: Adib Mehdi , Pashazadeh Rahim , Rajai-Daryasarei Saideh , Kabiri Roya , Jahani Mehdi
Published: November 2016

A new and efficient transition metal-free oxidative cross-dehydrogenative coupling (CDC) reaction is described for the preparation of 4-aroylcoumarin derivatives.
Low-temperature densification of Al-doped Li7La3Zr2O12: a reliable and controllable synthesis of fast-ion conducting garnets
Authors: El-Shinawi Hany , Paterson Gary W. , MacLaren Donald A. , Cussen Edmund J. , Corr Serena A.
Published: November 2016

A hybrid sol–gel solid-state procedure employing 3 h calcination at 1100 °C is used to produce fast-ion conducting Al-doped Li7La3Zr2O12.
3D hierarchical CoO@MnO2 core–shell nanohybrid for high-energy solid state asymmetric supercapacitors
Authors: Li Chao , Balamurugan Jayaraman , Thanh Tran Duy , Kim Nam Hoon , Lee Joong Hee
Published: November 2016

The 3D CoO@MnO2 core-shell nanohybrid based asymmetric supercapacitors deliver an excellent energy density (~85.9 Wh kg−1), an ultra-high power density (~16769 W kg−1 at 51.7 Wh kg−1), and remarkable cycle stability (86.8% capacitance retention after 10 000 cycles).
A facile synthetic route for highly durable mesoporous platinum thin film electrocatalysts based on graphene: morphological and support effects on the oxygen reduction reaction
Authors: Cho Kie Yong , Yeom Yong Sik , Seo Heun Young , Kumar Pradip , Baek Kyung-Youl , Yoon Ho Gyu
Published: November 2016

Porous-structured platinum thin film electrocatalysts offer highly enhanced ORR activity and durability benefits based on a large surface area and interconnected nanostructure.
High performance free-standing films by layer-by-layer assembly of graphene flakes and ribbons with natural polymers
Authors: Moura D. , Caridade S. G. , Sousa M. P. , Cunha E. , Rocha H. C. , Mano J. F. , Paiva M. C. , Alves N. M.
Published: November 2016

In this work, novel free-standing (FS) films based on chitosan, alginate and graphene oxide (GO) were developed through layer-by-layer assembly.
Enhanced green fluorescence protein/layered double hydroxide composite ultrathin films: bio-hybrid assembly and potential application as a fluorescent biosensor
Authors: Zhang Ping , Hu Yuehua , Ma Ruili , Li Ling , Lu Jun
Published: November 2016

This article reports the fabrication and application of enhanced green fluorescent protein/layered double hydroxide nanosheet (EGFP/LDH)n ultrathin films via layer-by-layer assembly technique based on electrostatic and hydrogen-bond interactions.
Solution-processed electron-only tandem polymer light-emitting diodes for broad wavelength light emission
Authors: Cho Sung Hwan , Kim Eui Hyuk , Jeong Beomjin , Lee Ju Han , Song Giyoung , Hwang Ihn , Cho Himchan , Kim Kang Lib , Yu Seunggun , Kim Richard Hahnkee , Lee Seung Won , Lee Tae-Woo , Park Cheolmin
Published: November 2016

Solution-processed electron-only tandem polymer light-emitting diodes were developed for broad wavelength light emission under AC operation.
Fluorescent mesomorphic pyrazinacenes
Authors: Richards Gary J. , Ishihara Shinsuke , Labuta Jan , Miklík David , Mori Toshiyuki , Yamada Shinji , Ariga Katsuhiko , Hill Jonathan P.
Published: November 2016

Hexaazapentacene derivatives were N-substituted with hydrophilic and hydrophobic dendron-type substituents leading to different self-assembly behaviours including lamellar and columnar structures.
Latitude dependence of the solar granulation during the minimum of activity in 2009
Authors: Muller R. , Hanslmeier A. , Utz D.
Published: November 2016

Context.Knowledge of the latitude variation of the solar granulation properties (contrast and scale) is useful to better understand interactions between magnetic field, convection, differential rotation, and meridional circulation in the solar atmosphere.

Aims.We investigated the latitude dependence of the contrast and scale of the solar granulation, with the help of HINODE/SOT blue continuum images taken in the frame of the HOP 79 program, along the central meridian and along the equator on a monthly basis in 2009 during the last solar minimum of activity.

Methods.We selected the sharpest images in latitude and longitude intervals. The selected images in all the N-S and E-W scans taken in 2009 were combined to get statistically reliable results.

Results.The contrast of the solar granulation decreases towards the poles and the scale increases, but not regularly since a perturbation occurs at around 60° where both quantities return close to their values at the disk center.

Conclusions.Such a latitude variation in a period of minimum of activity (2009), is probably not due to magnetic field, neither the quiet magnetic field at the surface, nor the strong magnetic flux tubes associated with active regions, which could be embedded more or less deeply in the convection zone before they reach the surface. The decrease in contrast and increase in scale towards the pole seem to be related to the differential rotation and the perturbation around 60° to the meridional circulation.
Existence, regularity and structure of confined elasticae
Authors: Dayrens François , Masnou Simon , Novaga Matteo
Published: November 2016

We consider the problem of minimizing the bending or elastic energy among Jordan curves confined in a given open setΩ. We prove existence, regularity and some structural properties of minimizers. In particular, whenΩis convex we show that a minimizer is necessarily a convex curve. We also provide an example of a minimizer with self-intersections.
Les objets connectés peuvent-ils aider les patients atteints de pathologies neuromusculaires ?
Authors: Beckmann Eytan , Vignaux Jean-Jacques
Published: November 2016

L’explosion des technologies connectées (capteurs synchronisés avec une application mobile) est aujourd’hui incontestable. Pourtant peu d’applications s’adressent aux maladies rares [1].À l’aide d’exemples adaptés à la maladie de Duchenne, nous proposons de montrer, que des données vitales, comportementales, fonctionnelles, etc. recueillies en continu par le patient lui-même, permettraient d’anticiper ou de prévenir des complications (orthopédiques, cardiaques ou respiratoires, etc.), et d’offrir ainsi la perspective d’une meilleure prise en charge médicale, et d’une amélioration de sa qualité et de son espérance de vie.
La prise en charge respiratoire chez le patient neuromusculaire
Authors: Boussaïd Ghilas , Devaux Christian , Lofaso Frédéric
Published: November 2016

Une journée consacrée à la prise en charge respiratoire du patient neuromusculaire a été organisée le 16 septembre 2016 par l’AFM-Téléthon, en collaboration avec la SPLF (Société de Pneumologie de Langue Française) et l’Université de Versailles-Saint-Quentin-en-Yvelines (HandiMedex). Cliniciens, scientifiques et industriels ont échangé sur les conséquences engendrées par une ventilation mécanique au quotidien, en mettant l’accent sur L’existant et Le souhaitable.
La Finlande : un héritage génétique idéalement mis en valeur
Authors: Udd Bjarne , Brignol Tuy Nga , Andoni Urtizberea J.
Published: November 2016

Si la Finlande est souvent assimilée à une « petite » nation du fait de la taille restreinte de sa population, elle n’en est pas moins un géant en matière de myologie. Sa contribution, très originale, à la découverte de nombreuses myopathies et neuropathies héréditaires est là pour le prouver. Rarement pays aura valorisé son patrimoine génétique autant que la patrie de Sibelius. Particulière par les origines de sa population et fière de sa langue non-indo-européenne, la Finlande cultive pourtant une ouverture d’esprit et une volonté de collaboration sans pareilles. Deux qualités très utiles et très appréciées dans le concert international des équipes travaillant dans le domaine neuromusculaire.
Clin d’œil du Dinosaure émérite
Authors: Kaplan Jean-Claude
Published: November 2016

Aux États-Unis, les associations de familles de DMD sont montées au créneau pour demander l’agrément par la FDA de la première molécule induisant un saut d’exon thérapeutique. Fait sans précédent et méritant un Clin d’œil, elles ont obtenu satifsfaction.
An accurate potential model for the a3Σu+ state of the alkali dimers Na2, K2, Rb2, and Cs2
Authors: Lau Jascha A. , Toennies J. Peter , Tang K. T.
Published: November 2016

A modified semi-empirical Tang-Toennies potential model is used to describe the a3Σu+ potentials of the alkali dimers. These potentials are currently of interest in connection with the laser manipulation of the ultracold alkali gases. The fully analytical model is based on three experimental parameters, the well depth De, well location Re, and the harmonic vibrational frequency ωe of which the latter is only slightly optimized within the range of the literature values. Comparison with the latest spectroscopic data shows good agreement for Na2, K2, Rb2, and Cs2, comparable to that found with published potential models with up to 55 parameters. The differences between the reduced potential of Li2 and the conformal reduced potentials of the heavier dimers are analyzed together with why the model describes Li2 less accurately. The new model potential provides a test of the principle of corresponding states and an excellent first order approximation for further optimization to improve the fits to the spectroscopic data and describe the scattering lengths and Feshbach resonances at ultra-low temperatures.
Lock-in in forced vibration of a circular cylinder
Authors: Kumar Samvit , Navrose  , Mittal Sanjay
Published: November 2016

The phenomenon of lock-in/synchronization in uniform flow past an oscillating cylinder is investigated via a stabilized finite element method at Re = 100. Computations are carried out for various amplitudes and frequencies of cylinder oscillation to accurately obtain the boundary of the lock-in regime. Results from earlier studies show a significant scatter in the lock-in boundary. The scatter might be an outcome of the difference in data collection or the use of a different criterion for identifying lock-in. A new criterion for lock-in is proposed, wherein the following two conditions are to be satisfied. (i) The most dominant frequency in the power spectrum of lift coefficient matches the frequency of cylinder oscillation (fy) and (ii) other peaks in the power spectrum, if any, are present only at super-harmonics of fy. Utilizing this criterion, three flow regimes are identified on the frequency-amplitude plane: lock-in, transition, and no lock-in. The behaviour of the wake is also investigated by examining the power spectra of the velocity traces at various locations downstream of the cylinder. Wake-lock-in is observed during lock-in. A wake-transition regime is identified wherein the near wake, up to a certain streamwise location, is in a lock-in state while the downstream region is in a desynchronized state. For a fixed fy, the location beyond which the wake is desynchronized moves downstream as the amplitude of oscillation is increased. The proposed criterion for lock-in addresses the wide scatter in the boundary of the lock-in regime among earlier studies. Energy transfer from the fluid to the structure, per cycle of cylinder oscillation, is computed from the data for forced vibration. The data is utilized to generate iso-energy transfer contours in the frequency-amplitude plane. The free vibration response with zero structural damping is found to be in very good agreement with the contour corresponding to zero energy transfer.
Vertical excitation energies from the adiabatic connection
Authors: Becke Axel D.
Published: November 2016

Vertical single-particle excitations from closed-shell ground states are complicated by the fact that the singlet open-shell states are, even in the first approximation, two-determinantal. Thus two-electron integrals come into play and standard time-independent DFT (density-functional theory) does not apply. In this work, we use the “adiabatic connection” to analyse the role of the two-electron integrals, obtaining a time-independent DFT approach to excitation-energy calculations that is new and simple. A non-empirical modeling of the method works as well as the popular TD-B3LYP time-dependent approach to excited states, and can be made even simpler by introducing one reasonable semi-empirical parameter.
Single-phase driven ultrasonic motor using two orthogonal bending modes of sandwiching piezo-ceramic plates
Authors: Ma Yuting , Choi Minkyu , Uchino Kenji
Published: November 2016

A compact ultrasonic motor using sandwiching piezo-ceramic plates was developed, having advantages of low manufacturing costs, simple driving circuit, and high scalability. The stator is composed of two piezoelectric plates attached to a T-shaped steel body. Two orthogonal bending modes can be excited by driving one piezoelectric plate and the reversed motion of the rotor can be obtained by driving the piezoelectric plate on the opposite side. The prototype stator with a size of 15 mm × 2.44 mm × 2 mm, operated at 44.8 kHz, was experimentally characterized, and a maximum torque of 2 mN m was obtained. Maximum power of 2.3 mW and efficiency of 9% were produced with a load of 0.8 mN m at a rotation speed of 27 rpm.
Research on the best measurement situation between optical probe and tissue surfaces in non-invasive detection
Authors: Yu Xuyao , Liu Rong , Yu Hui , Wang Jiao , Wang Jun , Xu Kexin
Published: November 2016

Near-infrared spectroscopy is often used for the non-invasive detection of composition in the human body, such as that of blood glucose and haemoglobin, due to its high penetration depth into tissues. Although it is feasible to position the optical probe precisely, contact situation between probe and human tissues is a difficult problem to determine because of physiological tremor and mechanical performance of bio-soft tissue. Here, we proposed a novel estimation method for the situation between the optical probe and tissue surfaces based on the dynamic auto-correlation matrix of two-dimensional correlation spectroscopy (2DCOS) and radar chart. The diffuse reflectance spectra from the left palm of 4 healthy volunteers were collected while the optical probe gradually approached and pressed bio-tissues with a custom-design controlling device. 2DCOS in the wavelength with lower absorption (1000-1400 nm) was calculated under the perturbation of relative-distance and contact pressure between the optical probe and tissue surface. The synchronous 2DCOS showed that the surface reflection and diffuse reflectance were greatly affected by the contact conditions in 1100 nm, 1220 nm, and 1300 nm. Then the dynamic auto-correlation matrix of 2DCOS was established for the adjacent spectra, and the significant difference wavelengths were used to build radar charts to determine the critical contact situation visually. Results showed that the maximum variations of dynamic auto-correlation matrix appeared at near 1300 nm, and the relative distance between the probe and tissue corresponding to the critical contact state can be easily observed with radar charts with 0.25 mm uncertainty, which was consistent with the self-feeling of each volunteer. So this method can be applied to exactly determine the optimal measurement status for the non-invasive body composition detection in vivo. It is important for the design of human-machine interface and the accuracy improvement of body composition measurements.
Gentle transfer method for water- and acid/alkali-sensitive 2D materials for (S)TEM study
Authors: Lin Junhao , Lin Yung-Chang , Wang Xinsheng , Xie Liming , Suenaga Kazutomo
Published: November 2016

We report a method in making transmission electron microscopy sample for both CVD-grown and exfoliated 2D materials without etching process, thus gentle to those 2D materials that are sensitive to water and reactive etchants. Large-scale WS2 monolayer grown on glass, NbS2 atomic layers grown on exfoliated h-BN flakes, and water-sensitive exfoliated TiS2 flakes are given as representative examples. We show that the as-transferred samples not only retain excellent structural integrity down to atomic scale but also have little oxidations, presumably due to the minimum contact with water/etchants. This method paves the way for atomic scale structural and chemical investigations in sensitive 2D materials.
An influence of the local strain on cathodoluminescence of GaN/AlxGa1−xN nanowire structures
Authors: Reszka Anna , Wierzbicka Aleksandra , Sobczak Kamil , Jahn Uwe , Zeimer Ute , Kuchuk Andrian V. , Pieniążek Agnieszka , Sobanska Marta , Klosek Kamil , Zytkiewicz Zbigniew R. , Kowalski Bogdan J.
Published: November 2016

Near-band-edge excitonic emission shift is investigated as a measure of the local strain in GaN nanowires with single AlxGa1−xN sections of various Al contents (x = 0.0, 0.22, 0.49, 1.0). Complementary data obtained by spatially and spectrally resolved cathodoluminescence spectroscopy and imaging of individual nanowires at low temperature, high resolution X-ray diffraction, and transmission electron microscopy are used to determine the correspondence between the cathodoluminescence emission energy and the strain in the GaN core of the nanowire surrounded by the AlxGa1−xN shell formed during the growth of AlxGa1−xN sections by catalyst-free plasma-assisted molecular beam epitaxy. In majority of nanowires, the blue-shift of GaN cathodoluminescence follows the evolution expected for the GaN core under uniaxial compressive strain along the axis of the structure.