bluuebunny/crossref_metadata_2025 huggingface dataset:
The Unicorn Phenomenon: An Embeddedness-Based View of Influencing Factors
Authors: Hammoda Basel , Küttim Merle
Published: November 2024

Unicorns are a special breed of an entrepreneurial phenomenon that is gaining increased attention from theoretical and practical perspectives. This emerging niche, however, lacks structurization and sufficient investigation of the development of a unicorn firm. The article aims to investigate the factors influencing the emergence and growth of unicorns, using embeddedness as a theoretical framework. It follows a systematic review of empirical articles investigating the unicorn phenomenon based on a search in Scopus and Web of Science databases. A total of 17 articles were qualified and reviewed in depth for descriptive information and the factors impacting unicorns. The findings confirm that the unicorn phenomenon is a new entrant in entrepreneurship research, with the first study published in 2017. Most of the empirical work relied on secondary data to analyze this phenomenon, with a split of geographical focus between the leading countries (US and China) and the developing ones. The identified influencing factors were analyzed and organized into three levels: context, firm, and individual. They highlight the necessary elements in an entrepreneurship ecosystem, a company’s business and operating models, and the characteristics of founders and unicorns’ leaders for supporting the development of a potential unicorn. This study extends the concept of embeddedness to this special breed of companies and provides insights for ambitious entrepreneurs who want to grow their companies to a unicorn status and to policymakers on providing an enabling environment to attract startups and promote entrepreneurship.
Proteostasis collapse in rat’s lung tissue as one of the effects of European adder (Vipera berus subsp. berus and Vipera berus subsp. nikolskii) envenomation
Authors: Shchypanskyi Serhii , Maievskyi Oleksandr , Lasavutz Vladyslav , Sokurenko Liudmyla , Raksha Nataliia , Halenova Tetiana , Vovk Tetiana , Savchuk Olexii
Published: November 2024

Snakebites and their consequences are a growing concern around the globe. The mixture of enzymes, present in snake venom is a great challenge for a snakebite victim’s body. European adder (Vipera berus) is considered as not very harmful snake due to the mild clinical symptoms of envenomation and rare cases of cardiovascular or pulmonary failure. Nevertheless, at the molecular level, many details of V. berus bite (including proteostasis instability) remain unclear. This work was aimed to determine the effect of Eastern Europe typical adder species Vipera berus berus and Vipera berus nikolskii envenomation on the protein homeostasis of rat’s lung tissue. The decrease in total protein concentration, significant redistribution of main protein fractions (including proteolytically active), rise in middle-mass molecules and low molecular weight peptide concentration have been observed during V. b. berus and V. b. nikolskii envenomation, strongly indicating the proteostasis collapse and endogenous intoxication in lung tissue as an effect of European adder snakebite. Moreover, according to the results of experiments, the effect of V. b. nikolskii venom is more harmful to lung tissue protein homeostasis, comparing to V. b. berus, suggesting that the former may represent a greater danger to people. The results of this study may find applications in antivenom development and could be taken into consideration for proper snakebite treatment selection in order to avoid proteome complications in patients.
Formulation and evaluation of herbal tablet of jackfruit root for the treatment of antiasthmatic activity
Authors: Mankar Someshwar Dattatraya , Siddheshwar Suhas Shivaji , Dighe Santosh B. , Bhawar Sanjay B.
Published: November 2024

Jackfruit is a highly nutritious plant. The ancient fruit known as jackfruit (Artocarpus heterophyllus Lam) is commonly eaten raw. Documenting the therapeutic value of the main jackfruit parts (Artocarpus heterophyllus L.) was the primary goal of this study. It contains more protein, calcium, iron, and Thiamine. Jackfruit contains many classes of phytochemicals such as carotenoids, flavonoids, volatile acids sterols, and tannins, with varying concentrations. The excellent medicinal efficacy of Artocarpus has long been recognized. Phenolic compound test. Next, using a direct comparison approach, we developed pills for asthma. After that, check evaluations such as degradability, hardness, friability, homogeneity of content, weight change, solubility, etc. The health benefits of jackfruit are attributed to its many physicochemical applications. Jackfruit is some tropical fruit rich in 4,444 nutrients such as carbohydrates, proteins, vitamins, minerals, and digestive fiber to maintain bronchial pain relief. In the case of asthma, a person suffers from bronchospasm and this herbal tablet acts as a bronchodilator. Therefore, we examined the antiasthamatic characteristics using a herbal mixture prepared from jackfruit root. Jackfruit contains vitamin A, vitamin C, thiamin, riboflavin, calcium, potassium, iron, sodium, zinc, and niacin, among many other nutrients.
The impact of gut microbiota on mental health
Authors: Neska Aleksandra , Kedzierska Ewa , Gibula-Tarlowska Ewa
Published: November 2024

Microorganisms inhabit various areas of the human body, but by far the most numerous and diverse in species is the intestinal microbiota. This consists of an enormous number of microorganisms, the largest group of which are bacteria. Currently it is well known that microbiota affects the proper functioning of the brain, therefore, it has become the subject of interest in the field of mental diseases treatment. Numerous studies have shown both quantitative and qualitative disturbances in the composition of the intestinal microbiome in people suffering from depression. Psychobiotics are a category of probiotics that influence the gut microbiota and positively impact brain and nervous system function. The potential antidepressant role of psychobiotics is also indicated, however, presently, they do not have the status of drugs. It is well known that they induce various beneficial effects, such as reducing the level of cortisol and the activity of the hypothalamic-pituitary-adrenal (HPA) axis, as well as modulating the activity of the vagus nerve. Furthermore, the studies conducted so far allow to confirm the relationship between the composition and abundance of intestinal microflora and occurrence of various mental diseases, including: depression, schizophrenia, bipolar disorder, autism and attention deficit hyperactivity disorder (ADHD).
Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity?
Authors: Szponar Jaroslaw , Gorska Agnieszka , Ostrowska-Lesko Marta , Wielgomas Bartosz , Mandziuk Slawomir
Published: November 2024

Doxorubicin (DOX) is a cytostatic drug with a broad spectrum of anticancer activity that has been used in oncology for over 50 years. Among many adverse effects in humans, the most dangerous is late dilated cardiomyopathy, which appears even years after completion of therapy. However, in cats, the critical organ for the toxic effects of DOX is the kidney. Herein, nephrotoxicity is manifested as azotemia. The main aim of our study was to evaluate the protective effect of dexrazoxane (DEX) and carvedilol (CVD) against the nephrotoxic effects of DOX. Nephrotoxicity studies were performed in a rat model of repeated DOX administration. Analyzed blood morphological, biochemical and histopathological findings revealed that DEX has a dual effect: it positively impacts DOX-induced histological alterations and creatinine levels while negatively affecting urea concentration. Thus, the results do not support univocally recommend DEX to prevent nephrotoxicity caused by DOX in cats. However, further studies using initially lower doses of DEX are needed to assess the prevention of nephrotoxicity in cats clinically treated with DOX.
Exploring the antihypertensive potential of natural compounds from Zygophyllum sp plant: An in-silico investigation of ACE inhibition
Authors: Bouchentouf Salim , Arbi Bouziane , Kowalska Grazyna , Kowalski Radoslaw
Published: November 2024

Hypertension, a major contributor to global mortality, requires comprehensive management including lifestyle changes and medication. This study explores the potential of natural compounds from Zygophyllum sp as Angiotensin-converting enzyme (ACE) inhibitors, a key class of antihypertensive drugs. Using molecular docking methodology, we investigated the inhibitory effects of these compounds on the ACE enzyme (PDB: 1UZF). Our work demonstrated that several molecules exhibited promising binding scores compared to established reference ligands, suggesting potential ACE-inhibiting properties. Myristic acid showed the most favorable score (-9.2454 kcal/mol), surpassing conventional reference drugs. Geranyllinalool, Pseudophytol, Methyl linoleate and Phytol also demonstrated superior scores. 1-Octadecene and linoleic acid outperformed captopril and aligned closely with other reference ligand scores. The computational scores, largely exceeding those of established drugs, indicate strong affinities between Zygophyllum sp
’
s chemical constituents and the ACE enzyme. This suggests potential antihypertensive properties of the plant and its bioactive components, supporting its traditional use as an antihypertensive remedy. The notable efficacy scores of select known therapeutic agents further validate this potential. However, additional in-vitro and in-vivo investigations are necessary to robustly establish the ACE-inhibitory capability of Zygophyllum sp compounds. This study provides a foundation for further research into natural antihypertensive treatments, potentially offering new avenues for managing this widespread health concern.
The use of non-steroidal anti-inflammatory drugs (NSAIDs) in clinical practice for the treatment of periodontitis: a narrative review
Authors: Zajac-Grabiec Anna , Kuznik Magdalena , Penno Marta , Czopek Anna , Miszczyk Justyna
Published: November 2024

After dental caries, the most common multifactorial oral disease is periodontal disease. Periodontitis can result in biofilm and host dysbiosis, ultimately causing inflammation and destruction of periodontal tissues. This narrative review aimed to summarise and discuss the mechanism of action, categories and use of non-steroidal anti-inflammatory drugs (NSAIDs) in clinical practice in the treatment of periodontitis because of their analgesic, anti-inflammatory and reducing effects on platelet aggregation and thus bleeding. Also, this review illustrates the importance of studies demonstrating synergism between specialty drugs and their derivatives as valuable active substances. The eleven clinical trials conducted in small groups of adult volunteers (14-50) treated with various NSAIDs, e.g. aspirin, ibuprofen, diclofenac, ketoprofen and tenoxicam are discussed. The results of clinical trials have shown that the use of NSAIDs together with surgical intervention in the treatment of periodontal diseases produces beneficial effects as an adjunctive treatment. It is worth noting that these studies were conducted on small cohorts of adult volunteers, with variations in the duration of treatment and doses of administered drugs. Further research on the impact of NSAIDs administration on periodontal disease may provide in-depth knowledge of patient groups with different demographics, including age, gender and comorbidities. Additional research is necessary to explore the use of NSAIDs in combination with periodontitis treatment for different patient groups.
Multi-generational challenges and mental health of LGBTQ+ older adults in Slovenia
Authors: Nedeljko Mihael , Perović Barbara Toplak , Grah Miran , Kaučič Boris Miha
Published: November 2024

Aim. The purpose of the study was to determine whether diff erences in mental health exist among younger and older generations of LGBTQ+ older adults.

Material and methods. A quantitative approach was taken. The questionnaire was completed by 318 LGBTQ+ older adults (50+) from Slovenia who met the inclusion criteria and were selected using a non-random purposive sample. For statistical analysis, we used exploratory factor analysis (EFA) and the Mann-Whitney U test to compare the two independent groups.

Results. We received 318 fully completed questionnaires in the survey. EFA extracted one factor. The results demonstrate statistically signifi cant diff erences in mental health between younger and older generations of LGBTQ+ older adults for two items: I often experience stress and I have become more resilient due to facing many inequalities in society. The younger generation of LGBTQ+ older adults is more likely to report experiencing stress, but at the same time expresses a sense of resilience.

Conclusions. Despite the stress, LGBTQ+ older adults – especially the younger generation – have developed resilience to overcome challenges and improve mental health. Addressing the specifi c needs of LGBTQ+ older adults and improving their mental health requires elimination of prejudice and discrimination, and taking into account the complexity of their identities and experiences.
The initial results of MRI-TRUS fusion prostate biopsy in high volume tertiary center
Authors: Smrkolj Tomaz , Taskovska Milena , Ditz Iztok , Cernelc Klemen , Hawlina Simon
Published: November 2024

Background

Multiparametric magnetic resonance imaging (mpMRI) is a prerequisite for targeted prostate biopsy. The aim of our study was to evaluate the performance and learning curve of the mpMRI-transrectal ultrasound (TRUS) software image fusion (MRI-TRUS fusion) biopsy (BX) process in the first year after its introduction in our urology department.

Patients and methods

MRI-TRUS fusion BX was performed in 293 patients with at least one Prostate Imaging-Reporting and Data System (PIRADS) ≥3 lesion. The proportion of patients and lesions with positive histopathologic result for prostate cancer (PCa) was analyzed. The learning curve for MRI-TRUS fusion BX was assessed at institutional and individual level. Positive BX lesions were further analyzed by PIRADS and Gleason scores.

Results

The proportion of patients with positive histopathologic results for targeted BX, systematic BX, and combined BX was 53.9%, 47.9%, and 63.5%, respectively. The chi-square test for the proportion of PCa positive patients showed no significant difference between the time-based patient groups at the institutional level and no significant difference between individual urologists. PIRADS score (p < 0.001), total PSA concentration (p = 0.05), prostate volume (p < 0.001) and number of cores per lesion (p = 0.034) were significant predictors of a positive histopathologic result in a lesion-based analysis. Clinically significant PCa (csPCa) was confirmed in 34.7% of the 412 BX lesions and 76.4% of the 187 positive PCa lesions.

Conclusions

MRI-TRUS fusion targeted BX significantly improves the overall rate of PCa detection compared with systematic BX alone. No steep learning curve was observed in our urologists. The proportion of lesions with clinically insignificant PCa was low, limiting overdiagnosis of PCa.
Changing Profiles of Housing Deprivation in European Union Countries
Authors: Matel Anna
Published: November 2024

Housing deprivation is often analyzed as the proportion of population affected by housing problems related to a variety of issues. As a result, even if the level of housing deprivation is similar across countries, they may face different housing-related problems. In the presented research, an attempt was made to identify countries similar in terms of the area of housing problems. The specified dimensions were: (1) housing quality, (2) way of using the dwelling, and (3) neighborhood-related issues. The analysis indicated that in the EU, there are countries that do not show an intensification of housing deprivation in any of the areas. In 2020, these were Czechia, Austria, Estonia, and Finland. Countries with a deprivation profile related to housing quality were Romania, Lithuania, Latvia, and Cyprus; and to a lesser extent, also Hungary, Ireland, Slovenia and Belgium. Housing deprivation was mainly related to the way of using the dwelling in Greece, Bulgaria, and - to a lesser extent – also in Denmark, Poland, Croatia and Slovakia. The deprivation profile related to the neighborhood was identified in Malta, the Netherlands, France, and - to a lesser extent - also Spain, Portugal, Italy, Luxembourg, Sweden, and Germany. Housing deprivation profiles in the EU undergo changes in the 2010-2020 decade.
Investigation of the Dependence of the Technological Parameters of Laser Cutting to Minimize the Deviation from the Nominal Dimensions of the Parts
Authors: Čačko Viliam , Čačková Iveta , Richtáriková Daniela , Šooš Ľubomír
Published: November 2024

The purpose of the published research is to investigate the dependence of the technological parameters (cutting speed, focal length, and gas pressure) of fiber laser cutting to obtain the minimum deviation of the diameters of the parts from the nominal dimensions. The result is a mathematical model and optimized values for setting the fiber laser cutting machine’s technological parameters for the given material type. The optimized laser cutting parameters also depend on the kind of material. The entire research is focused on developing a global auto-calibration system for optimizing laser cutting parameters for different thicknesses and types of materials.
The Effect of Composition of Synthesis Gas on the Parameters of Supercharged Combustion Engine
Authors: Chríbik Andrej , Luknár Lukáš , Hošták Peter , Jančo Roland
Published: November 2024

Synthesis gases produced from municipal waste or plastic waste pose a great alternative source of energy, as they are not only reducing dependency on the fossil fuels, but also diversify energy sector and reduce the amount of a landfilled waste. This is directly related to the recent initiatives and legislation related to the greening of transport. The presented contribution focuses on the influence of six selected synthesis gases on the internal parameters of an internal combustion engine intended for cogeneration. The investigated gases fall into the category of medium-energy gases (8 – 14 MJ.kg−1). The experimental measurements have shown that mainly the proportion of hydrogen in the mixture has an effect on shortening the burning time and also on the maximum rate of pressure increase. A higher proportion of CO and H2 increased the maximum combustion pressure with slightly reduced power. The concentration of CH4 directly affected the volumetric value of the heating value of the mixture with a subsequent direct effect on the IMEP or engine torque. The engine operating at full load at speed of 1500 min−1, when running on the selected mixtures in comparison with the operation on natural gas, decreased its engine torque in the range between 13 and 20% and increased its hourly fuel consumption from 2.31 kg.h−1 for natural gas to the span of 7.90 - 12.30 kg.h−1 for measured gases. During the measurement of the control characteristic all investigated synthesis gases have developed an abnormal (detonation) combustion near the optimum pre-ignition angle.
Improvement of the Internal Combustion Engine Sleeve Spring Packets Equipped Coupling Calculation Model
Authors: Protsenko Vladyslav , Rusanov Sergiy , Kliuev Oleg , Voitovych Olha , Protasov Roman
Published: November 2024

The presented studies made it possible to clarify the calculation model of the diesel engine clutch with packages of sleeve springs. The stressed state of the spring packets is considered, while it is proposed to place the point of application of the radial force, which bends the spring package, in the zone of its greatest flexibility. Calculations performed according to the obtained expressions showed a coincidence with the results of experimental studies by other authors within 4% and with simulations conducted using automated design systems.
Mechanism for Debarking Logs When Performing Logging Operations Using a Forest Harvester
Authors: Rukomojnikov Konstantin P. , Alexagina Natalia N.
Published: November 2024

The purpose of the proposed modernization was to create the possibility of harvesting assortments simultaneously with stripping the bark in longitudinal strips to accelerate the natural drying of wood without reducing the productivity of the device compared to its counterparts. The goal was achieved and the forest harvester equipped with the new device was able to harvest debarked logs.
Fatigue Experimental of AS-CAST Ti-6Al-7Nb Implemented on Designed Femoral Stem for Indonesian People Through Finite Element Analysis
Authors: Galih Taqwatomo , Aghni Ulma Saudi , Damisih  , Nandang Suhendra , Mirza Wibisono , Giri Wahyu Alam , Nyoman Jujur I , Winda Rianti , Siti Amalina Azahra , Muhammad Dikdik Gumelar , Dita Adi Saputra , Saddam Husin , Riastuti Fidyaningsih
Published: November 2024

This study aims to evaluate the durability of as-cast Ti-6Al-7Nb in femoral stem application using fatigue analysis. As-cast Ti-6Al-7Nb rod specimens were tested experimentally with load range of 120%, 100%, 90%, 80%, 70%, 50%, 30%, and 20% relative to the yield strength. The fatigue limit was identified on a range of 141 - 211 MPa, represented by two run-out specimens running until high fatigue cycle (HFC) of 107 without failure. ProFatigue contributed to expose the estimation of the expected failure cycle on fatigue limit stress of as- cast Ti-6Al-7Nb based on Weibull modelling. It was predicted by probability failure (Pfail) of 50%. The failure cycles were revealed at 2.144 x 107 and 2.823 x 109 cycles on amplitude stress of 211 and 141 MPa, respectively. The reliability of the designed femoral stem for Indonesian people has been analyzed under ISO 7206 configuration through finite element analysis by adopting the material properties of as-cast Ti-6Al-7Nb. The static linear analysis demonstrated the maximum stress concentration of 136 MPa occurring over the medial region of the femoral stem, showing lower stress levels compared to the fatigue limit of as-cast Ti-6Al-7Nb. Furthermore, the lifetime analysis computed that the design could withstand cyclic loading until 2.51 x 109 cycles with fatigue safety factor and damage factor in 1.763 and 0.398, respectively. Results concluded that the investment casting is evident to become an alternative manufacturing method of femoral stem made of Ti-6Al-7Nb.
Mechanisms of Bolt Preload Relaxation Arising from In-Plane Loads and Bolt Bending
Authors: Welch Michael
Published: November 2024

Classical analysis methods have shown that flexural, in-plane, deflections due to shear strain in the flange pack of preloaded bolted joints produce bending moments and tensile loads on bolts within the joint. These bending moments and tensile loads are most noticeable in joints that are required to support large in-plane loads and torsional moments. The shear loads on the bolt associated with the flexural deflections can result in the bolt head, or nut, slipping relative to the flanges. This slippage will in turn result in mechanical loosening of the joint. The bending moments associated shear loads and tensile loads produced by the combination of both out-of-plane and in-plane external loads and torsional moments are in addition to the bolt preload. These additional loads, combined with a high initial bolt preload, can cause yielding of the bolt, which can also result in relaxation of the initial preload. This article reviews earlier work in determining the tensile bolt stresses induced in preloaded bolts by the external loads and presents methods of calculating the amount of preload relaxation that could occur from each mechanism discussed.
Pricing Asian Options in Uncertain Stochastic Markets With Jumps
Authors: Chirima Justin , Matenda Frank Ranganai , Sibanda Mabutho
Published: November 2024

Objective: In practice, the securities industry is characterized by processes exhibiting both randomness and Liu's uncertainty, sometimes called uncertainty. This study proposes Asian option pricing models in uncertain random markets with jumps.
 
Theoretical Framework: This research is based on the concepts of probability, uncertainty, and uncertain stochastic differential equations (USDEs) with jumps.
 
Method: We use an uncertain random stock model with a jump to derive option pricing models in uncertain random markets with jumps. Using USDEs with jumps is a new paradigm in modeling dynamical systems. The solution to the extraordinary type of an uncertain stochastic differential equation (USDE) with jumps examined in this article combines a jump component and the geometric Itô-Liu process. It plays a pivotal role in deriving Asian option pricing formulae under study.
 
Results and Discussion: This study shows that objective randomness and subjective uncertainty are essential in pricing Asian options.
 
Research Implications: The proposed procedures in this branch of knowledge can be used to price Asian options.
 
Originality/Value: This study contributes to the literature by adequately capturing the effects of indeterminacy in pricing Asian options.
PENGARUH PENGETAHUAN DAN SIKAP REMAJA TERHADAP PERILAKU KONSUMSI JAMU DI KABUPATEN BANGKALAN
Authors: Hasan Fuad , Muslimah Muslimah , Destiarni Resti Prastika
Published: November 2024

Penelitian ini bertujuan untuk  menganalisis pengaruh pengetahuan dan sikap remaja terhadap perilaku konsumsi jamu dan probabilitas pengetahuan dan sikap dalam mempengaruhi konsumsi perilaku jamu. Data primer  dikumpulkan dari 97 responden  menggunakan kuesioner Data dianalisis menggunakan uji chi-square dan Odd Ratio. Hasil analisis menunjukkan bahwa pengetahuan dan sikap berpengaruh signifikan terhadap konsumsi jamu. Variabel pengetahuan memiliki peluang lebih tinggi dalam meningkatkan konsumsi jamu dibandingkan variabel sikap.
PELAPISAN BENIH EDAMAME MENGGUNAKAN MIKORIZA DI BERBAGAI MEDIA TANAM
Authors: Nissa Nur Khoirun , Fariroh Indri
Published: November 2024

Kendala teknik budidaya pada lahan salin serta rendahnya mutu benih bisa diatasi dengan pelapisan benih menggunakan mikoriza. Penelitian menggunakan RAK faktorial, yaitu pelapisan mikoriza (0 dan 12 g/kg benih) dan media tanam (tanah, pasir salin, tanah + pasir salin). Hasil penelitian yaitu perlakuan tidak berpengaruh terhadap persentase daya tumbuh, tinggi tanaman, jumlah daun, jumlah biji/polong, persentase polong isi/tanaman. Benih yang dilapisi mikoriza menghasilkan bobot polong/tanaman lebih tinggi (51,3 g) dibandingkan tanpa pelapisan mikoriza (45,9 g).
KEUNGGULAN KARAKTER AGRONOMI MENTIMUN VARIETAS RTS 23
Authors: Khasanah Deah Anisatun , Rajiman Rajiman , Megawati Sari
Published: November 2024

Upaya untuk meningkatkan produktivitas dilakukan dengan cara menyediakan varietas  yang mempunyai keunggulan daya hasil tinggi dan ukuran sedang. Penelitian bertujuan untuk mengetahui keunggulan karakter agronomi mentimun varietas RTS 23. Penelitian ini dilaksanakan pada bulan Oktober 2023 sampai Januari 2024 di Kebun Riset CV Tunas Java Mandiri, Karangsari, Wedomartani, Ngemplak, Sleman, Daerah Istimewa Yogyakarta. Penelitian menggunakan Rancangan Acak Kelompok Lengkap (RAKL) 4 perlakuan yang terdiri dari  varietas RTS 23, varietas CU 699, varietas Monroe, dan varietas Ethana dengan 4 ulangan. Data dianalisis menggunakan analisis ragam dilanjutkan dengan BNJ 5%. Mentimun  varietas RTS 23 mempunyai keunggulan karakter agronomi berupa kulit buah tipis berkisar 4,82-5 mm, daya simpan buah lebih lama yakni berkisar 5-7 hari setelah panen, dan produktivitas rerata 15,61 ton/ha dan cocok ditanam pada musim kemarau.
Boletim de Saúde: Análise da Situação das Internações por Condições Sensíveis à Atenção Primária no Norte do Brasil
Authors: Bertelli Ellen Vanuza Martins , Dutra Viviane Gomes Parreira , Carvalho Gislayne Cristina Torreias de , Santos Ellen Suzy dos , Santos Naamá Gabriella Oliveira , Barros Francisco Railson Bispo de
Published: November 2024

O Boletim de Saúde: Análise da Situação das Internações por Condições Sensíveis à Atenção Primária no Norte do Brasil oferece uma visão detalhada e criteriosa das hospitalizações que poderiam ser evitadas com um atendimento primário eficaz e acessível. Este eBook foi concebido como uma ferramenta essencial para profissionais de saúde, gestores, pesquisadores e formuladores de políticas públicas interessados em compreender e enfrentar os desafios do sistema de saúde na região Norte do Brasil.

Nos últimos anos, a Atenção Primária à Saúde (APS) tem sido amplamente reconhecida como a base de um sistema de saúde eficiente e equitativo. No entanto, as Internações por Condições Sensíveis à Atenção Primária (ICSAP) continuam a representar uma parcela significativa das admissões hospitalares, refletindo falhas na organização e na efetividade dos serviços de saúde. Este boletim traz uma análise aprofundada das ICSAP, com foco nas peculiaridades regionais do Norte do Brasil, onde fatores geográficos, socioeconômicos e culturais desempenham um papel determinante na saúde da população.

Ao longo dos capítulos, exploramos dados recentes sobre as taxas de internação, identificamos as principais condições que levam às hospitalizações evitáveis.

Este eBook não apenas fornece uma análise estatística, mas também contextualiza os resultados dentro de um panorama mais amplo, considerando o contexto histórico e as políticas de saúde vigentes na região. Nosso objetivo é promover uma reflexão crítica sobre os desafios enfrentados pela APS no Norte do Brasil e fornecer subsídios para a formulação de políticas públicas mais eficazes e inclusivas.

Esperamos que este Boletim de Saúde contribua para o aprimoramento das práticas de gestão em saúde e inspire ações concretas que visem à redução das ICSAP, fortalecendo a Atenção Primária e, por conseguinte, melhorando a saúde e a qualidade de vida da população no Norte do Brasil.
ANTESEDEN CUSTOMER SATISFACTION DAN CORPORATE IMAGE TERHADAP LOYALTY MELALUI TRUST PADA NASABAH BANK MUAMALAT
Authors: Haryanti Denny Septa , Hernawati Nani , Prilyana Cindy , Anggiani Sarfilianty
Published: November 2024

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh Customer Satisfaction dan Corporate Image terhadap Loyalty melalui Trust pada nasabah Bank Muamalat di kota Bekasi. Desain penelitian ini menggunakan penelitian deskriptif dan kausalitas, pengukuran setiap variabel menggunakan 5 point Skala Likert. Penelitian ini menggunakan data primer dan sekunder serta pengumpulan data melalui kuesioner. Sampel penelitian diperoleh melalui metode purposive sampling dan diperoleh sebanyak 200 responden. Penelitian ini menggunakan metode statistic regresi linear berganda dengan SMARTPLS 3.2.9 sebagai alat pengujiannya. Hasil penelitian ini menunjukkan bahwa Customer Satisfaction memiliki pengaruh terhadap Trust, Customer Satisfaction memiliki pengaruh terhadap Loyalty, Corporate Image memiliki pengaruh terhadap Trust, Corporate Image memiliki pengaruh terhadap Loyalty, Trust memiliki pengaruh terhadap Loyalty.
LOW-WASTE TECHNOLOGIES FOR REDUCING HYDROCARBONS IN THE ATMOSPHERIC AIR
Authors: RYASNAYA O.I. , NOR P.E.
Published: November 2024

When using oil resources in one form or another, atmospheric air pollution with hydrocarbons almost always occurs. The tasks of this work included the organization of environmental protection measures at the oil pumping station in the field of atmospheric air protection. To do this, they gave a description of this object, the main type of its activity. In this paper, the possibility of using a system for capturing light fractions of hydrocarbons, which will allow them to be selected and disposed of, is considered. The system works by increasing the pressure in the gas space of the container with petroleum products (oil), until the moment when the «exhalation» into the atmosphere occurs. The introduction of such a low-waste capture system guarantees a reduction in hydrocarbon emissions into the atmosphere.
INVESTIGATION OF THE CHARACTERISTICS OF PARTIAL DISCHARGES IN SINGLE-CORE COAXIAL POWER CABLES
Authors: RANAEV S.A. , POLYAKOV D.A.
Published: November 2024

The use of new types of diagnostics of electrical equipment insulation is one of the possible solutions to the problem of imperfection of the existing diagnostic system. One of the most promising is the method of measuring partial discharges. The article discusses theoretical and experimental studies aimed at solving the complexity of the method in the analysis of measurements of amplitude-phase diagrams obtained from diagnostic results, as well as at simplifying the implementation of this method. To achieve these goals, literature sources were analyzed, types of defects in cable insulation were identified, experimental studies were conducted, which revealed the features of diagrams in accordance with the type of defect. The obtained results can be incorporated into new systems for analyzing the results of equipment diagnostics.
FEATURES OF PHASE-LOCK MOTOR DRIVE COMPUTER MODELLING IN LOW ROTATION SPEED
Authors: BUBNOV A.V. , DAINOVICH A.M. , DENISOVA V.V.
Published: November 2024

The phase-lock motor drive (PLMD) based on phase-lock loop principal has accuracy characteristics and wide shaft speed area. The research of PLMD in low shaft speed area is rather difficult because of non-linear waveform logical comparator’s output signal in phase-lock loop. The authors have developed the motor drive computer model in Matlab software. This model uses different types of demodulators - based on low-pass filter and sample-and-hold circuit. During the investigation the sample-and-hold computer model with special for PLMD sampling features was developed. As a result the transient waveforms in lock mode were received. The proposed computer model can be used for research and design of phase-lock motor drive.
Perfil epidemiológico da leishmaniose tegumentar americana no Estado do Pará, com ênfase na região do baixo Amazonas
Authors: Viana Milena Biá , Matos Wanessa Figueira Nunes de , Quaresma Tatiane Costa , Macêdo Caroline Gomes
Published: November 2024

Objetivo: Analisar o perfil clínico-epidemiológico da Leishmaniose Tegumentar Americana na região do Baixo Amazonas, no estado do Pará. Métodos: Trata-se de um estudo quantitativo descritivo mediante análise de dados clínico-epidemiológicos provenientes do Sistema de Informação de Agravos de Notificação (SINAN) disponibilizados pela Secretaria de Estado da Saúde do Pará (SESPA). Foram selecionados os casos de LTA do Baixo Amazonas, notificados no período de janeiro de 2012 a dezembro de 2022, e tabulados e analisados no software Excel. Resultados: Foram notificados 6824 casos no período analisado. Os dados demonstraram pequena flutuação de frequência ao longo dos anos. O mês de maior incidência de casos foi novembro. Quando analisadas as variáveis sociodemográficas, o sexo masculino (82%), a raça parda (82%) e a faixa etária acima de 30 anos (40%) apresentaram-se como os grupos de prevalência. O critério de confirmação foi o clínico-laboratorial (6507 casos) e a forma prevalente foi a cutânea (6721 casos). Conclusão: Identificou-se a pertinência do número de casos na região ao longo do período, evidenciando a necessidade do controle e prevenção da doença na região do Baixo Amazonas.
The role of oxytocin in the regulation of electrical activity of fallopian tubes in rats
Authors: Kazaryan Knarik , Hunanyan Naira , Danielyan Margarita , Mkrtchyan Arus , Chibukchyan Roza , Trofimova Yulia , Piliposyan Tatevik
Published: November 2024

Objectives:

The effect of oxytocin on spontaneous electrical activities of rhythmogenic areas in the right and left uterine horns (ovarian and cervical areas) was investigated in non-pregnant rats.

Materials and Methods:

Comparative analysis of the main characteristics of spontaneous activity (amplitude of action potentials [A]; mean rise- rate [V]; rise - time [T/2]; half-width [t] of spikes; total duration of bursts in 1 minute [D], and spike generation frequency [F]) was conducted. Morphofunctional properties of the rat uterine horns were studied by using a histochemical method, which had been developed based on the Homori method.

Results:

The left ovarian horn area is characterized by parameters significantly exceeding those of the other three areas, which are identical to each other. Administration of oxytocin, as a factor promoting increased excitability of the myometrium, led to significant enhancement of rhythmogenesis in the right ovarian horn area. Morphohistochemical results revealed an increase in enzymatic activity of the myometrium under the influence of oxytocin, with the right ovarian horn area showing the greatest changes.

Conclusion:

Since oxytocin plays a key role in stimulating activity and enhancing the myometrial contractions of the right fallopian tube, the possibility of additional reserve capabilities in the regulation of the integrative function of the reproductive organs cannot be excluded from the study.
АВТОМАТИЗАЦИЯ РАБОТЫ КОНТАКТ-ЦЕНТРА И ЕЕ РОЛЬ В УПРАВЛЕНИИ ОРГАНИЗАЦИОННЫМ ПОВЕДЕНИЕМ ПЕРСОНАЛА
Authors: А.С. Афонин-Терзийски
Published: November 2024

Статья посвящена вопросам автоматизации процессов в современных контакт-центрах. Анализируется роль автоматизации в вопросах управления организационным поведением персонала, уменьшения количества рутинной, монотонной работы и стресса, описываются новые возможности для руководителей по мониторингу за работой персонала, в т.ч. для работающих удаленно. Рассматриваются возможности применения автоматизации при помощи чат-бота, голосового бота, автоматизации сбора индекса лояльности клиентским сервисом (NPS), упрощения регистрации заявок, использования CRM-системы для управления персоналом.

The research is devoted to the process automation in modern contact centers. We analyze the role of automation in managing the organizational behavior of the personnel, reducing the amount of routine, monotonous work and stress and describe the new opportunities for managers to monitor the work of the employees, including those working remotely. We look at the examples of automation via using a chat bot, a voice bot, the automation of loyalty index calculating relying on customer service (NPS), application simplification, using CRM system for personnel management.
Towards Self-Driving Labs for Better Batteries: Accelerating Electrolyte Discovery with Automation and Bayesian Optimization
Authors: Yik Jackie T. , Hvarfner Carl , Sjölund Jens , Berg Erik J. , Zhang Leiting
Published: November 2024

The integration of automation and data-driven methodologies offer a promising approach to accelerating materials discovery in energy storage research. Thus far, in battery research, coin-cell assembly has advanced to become near fully- automated but remains largely disconnected from data-driven methods, which have been primarily developed for computational or multi-fidelity datasets. To bridge the disconnect, this work presents a self-driving laboratory framework designed to accelerate electrolyte discovery by integrating automated coin-cell assembly, galvanostatic cycling of LiFePO4||Li4Ti5O12 full cells, and Bayesian optimization for selecting subsequent experiments based on prior results. The integration of Bayesian optimization highlights machine-intelligent experimental decision-making enabling closed-loop experimentation-analysis workflow for self-driving laboratories. The study focuses on an organic-aqueous hybrid electrolyte system comprising four co-solvents dimethyl sulfoxide, trimethyl phosphate, acetonitrile, and water—and two salts, lithium perchlorate and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). Using this framework, high- performing electrolyte formulations were identified, with water content emerging as a key performance factor. Online electrochemical mass spectrometry provided insights into hydrogen evolution as a significant side reaction, while revealing limited effects due to co-solvent interactions. The results highlight the potential of combining Bayesian optimization with autonomous experimentation for improving efficiency in materials research, while contributing new insights into electrolyte behavior for next-generation aqueous lithium-ion batteries.
Clinical Application of Skin Wound Adhesive (Glue) in Skin Incisions
Authors: Kang Huafeng
Published: November 2024

Objective: To explore the clinical application of skin wound adhesive (glue) in skin incisions. Methods: Data from 46 patients who underwent surgery in our hospital between June 2024 and August 2024 were collected, focusing on breast surgery incisions as the study subject, with follow-up observations conducted for 1–2 weeks. Results: All incisions healed well without splitting, allergic reactions, or infections, and no adverse reactions were observed. Conclusion: The application of skin wound adhesive (glue) in breast surgery incisions is effective and safe; the adhesive process is convenient for external body incisions, eliminates the need for suture removal, shortens patient surgery and hospital stays, and reduces incision infection risk, resulting in satisfactory incision healing outcomes.
Medication Selection and Nursing Interventions for Parkinson’s Disease Patients
Authors: Lv Qian , Li Yingying , Wei Xiujuan
Published: November 2024

Parkinson’s disease is a neurodegenerative disorder that significantly impacts patients’ lives. Currently, treatment primarily relies on drug therapy, while effective nursing interventions can help mitigate adverse reactions associated with medication use. This article reviews medication selection and nursing interventions for patients with Parkinson’s disease, aiming to alleviate symptoms, improve quality of life, and provide a scientific and comprehensive basis for medication and clinical nursing practices.
Analysis of the Causes of Insomnia in Young and Middle-aged People and Nursing Intervention Strategies of Traditional Chinese and Western Medicine
Authors: Chen Weifeng , Qin Yanyan , Cheng Cheng , Zhou Xiaojia
Published: November 2024

Objective: To examine insomnia in the modern young and middle-aged population and explore nursing intervention strategies using traditional Chinese and Western medicine. Methods: A total of 255 inpatients and outpatients were sampled from Shenzhen Hospital of Traditional Chinese Medicine. The Sleep Questionnaire for Young and Middle-aged People was used to assess insomnia, and a linear regression model was applied for data analysis. Results: A total of 251 valid questionnaires were collected. Correlation analysis revealed a high incidence of insomnia among respondents. Linear correlation analysis indicated that mental illness or other underlying diseases leading to pain had a significantly positive effect on symptom improvement through Chinese and Western medicine treatments (B = 0.763, P < 0.01). Conversely, work or life pressures (emotional or financial issues) had a significantly negative impact on treatment effectiveness (B = -0.503, P < 0.01). Cross-analysis identified high life or work pressure as the primary cause of insomnia (70.1%). Conclusion: Insomnia is prevalent among the young and middle-aged in modern times, with high work or life pressure being the leading factor.
Epidemiological profile of patients with prostatic neoplasia in a high complexity oncology center
Authors: Grippa Wesley Rocha , Salaroli Luciane Bresciani , Lopes-Júnior Luís Carlos
Published: November 2024

Objective: To describe the profile of prostate cancer patients who sought hospital care at a Brazilian High Complexity Oncology Center, as well as their condition on arrival at the center. Methods: This is a descriptive observational study, based on secondary data from the tumor file in the Hospital Cancer Registry at Afecc-Hospital Santa Rita de Cássia. RStudio and R software were used for descriptive analysis. Results: A total of 5,403 new analytical and non-analytical cases of prostate neoplasms were analyzed between 2000 and 2016. The number of cases had a mean age of 69.40 years (SD=8.82), with an increasing trend over the period (p<0.001). The majority of patients were over 60 years old (86.82%), brown or white (91.97%), with incomplete primary education (52.88%), married (67.37%), referred by SUS (76.12%), with no other primary tumors (97.87%), and histological type classified as adenocarcinoma (96.22%). The variables age (p=0.017), race/skin color (p<0.001) and education (p<0.001) showed statistically significant differences between analytical and non-analytical cases. Conclusion: The analyses show an upward trend in the incidence of prostate cancer over the years, and prostate neoplasia has a tropism for older, married men with a low education level.
EFEKTIFITAS ZAT ADIKTIF DALAM MEMPERKECIL RESISTANSI PENTANAHAN GEDUNG PASCA SARJANA UNIVERSITAS ICHSAN GORONTALO
Authors: Pratiwi Amelya Indah
Published: November 2024

Diperlukan system pentanahan yang baik, yakni resistansi pentanahan total seluruh sistem tidak boleh lebih dari 5 ohm. Penelitian ini di lakukan di gedung Pascasarjana Universitas Ichsan Gorontalo dengan metode pentanahan yang digunakan yaitu metode 3 titik. Jenis tanah di lokasi tersebut yaitu tanah keras berbatu. Menggunakan 2 batang elektroda pentanahan dengan diameter masing – masing batang elektroda yaitu 2.5 mm, dengan panjang batang elektroda pentanahan yaitu 1 meter disusun secara paralel dan menambahkan dua jenis Zat adiktif berupa garam murni (NaCL) dan serbuk besi. Hasil pengukuran resistansi pentanahan menggunakan 1 batang elektroda yaitu 11 ohm, setelah ditambahkan garam NaCL sebanyak 1 kg resistansi pentanahannya turun menjadi 9.36 ohm. Resistansi pentanahan kembali turun setelah ditambahkan 1 kg zat besi yakni  9.05 ohm. Semakin besar takaran zat adiktif yang ditambahkan maka resistansi pentahannya semakin turun. Demikian juga ketika digunakan 2 batang pentanahan paralel kemudian ditambahkan zat adiktif maka nilai resistansi pentanahannya lebih kecil lagi yakni 5,45 ohm.
Estimation Methods for the Roll Damping Ratio of Floating Structures
Authors: Park Hyun Jung , Jung Yong Jae , Jung Kwang Hyo , Park Sung Boo , Choi Yong Ho , Chung Yun Suk , Lee Seung Jae
Published: November 2024

This study compares four estimation methods for determining the roll damping ratio using a series of free roll decay tests conducted in a two-dimensional wave tank. Numerous studies have been performed to estimate the roll damping ratio of floating structures while considering nonlinear effects. In this work, a floating structure was tested at four initial roll angles to investigate the nonlinear behavior at large roll motions. The roll natural periods were determined using the Fast Fourier Transform and the peak-to-peak method applied to the time series of the free roll decay test. At initial roll angles below 10°, the roll damping ratios derived from the four methods exhibited similar results. However, at initial roll angles exceeding 10°, the results varied significantly across the methods, likely due to differences in their treatment of nonlinear viscous effects. This study examines the applicability of these methods for various initial roll angles and recommends the minimum roll angle and the number of rolling period required for accurate calculations from free roll decay tests. Further studies are needed to evaluate roll damping ratios for motions exceeding 10° while accounting for nonlinear viscous damping effects.
The experience of the “anti-Zionist campaign” from the autobiographical perspective of its victims
Authors: Czyżewski Andrzej
Published: November 2024

The aim of this article is to deepen the reflection on the ways in which the events of March ’68 in Poland are described by those who were targeted by the brutal anti-Semitic campaign of the period. The main analytical category used here is “experience” as proposed by Martin Jay, in which the distinction between Erfahrung and Erlebnis is of fundamental importance. The proposed analysis is primarily based on the previously unused interviews with members of what is known as the “post-March emigration” collected at the POLIN Museum of the History of Polish Jews. Those are extensively supplemented by references to the already published “March ’68 narratives” gathered by, among others, Joanna Wiszniewicz, Krystyna Naszkowska and Mikołaj Grynberg.