bluuebunny/crossref_metadata_2025 huggingface dataset:
Gene expression signatures of breast cancer stem and progenitor cells do not exhibit features of Warburg metabolism
Authors: Gordon Nicole , Skinner Amy M. , Pommier Rodney F. , Schillace Robynn V. , O’Neill Steven , Peckham Jennifer L. , Muller Patrick , Condron Mary E. , Donovan Cory , Naik Arpana , Hansen Juliana , Pommier SuEllen J.
Published: August 2015

Introduction

Cancers are believed to adapt to continual changes in glucose and oxygen availability by relying almost exclusively on glycolytic metabolism for energy (i.e. the Warburg effect). The process by which breast cancers sustain growth in avascular tissue is thought to be mediated via aberrant hypoxia response with ensuing shifts in glycolytic metabolism. Given their role in initiating and perpetuating tumors, we sought to determine whether breast cancer stem and progenitor cells play an instrumental role in this adaptive metabolic response.

Methods

Breast cancer stem/progenitor cells were isolated from invasive ductal carcinomas, and benign stem cells (SC) were isolated from reduction mammoplasty tissues. Relative expression of 33 genes involved in hypoxia and glucose metabolism was evaluated in flow cytometrically isolated stem and progenitor cell populations. Significance between cohorts and cell populations was determined using Student’s 2-tailed t test.

Results

While benign stem/progenitor cells exhibited few significant inter-group differences in expression of genes involved in hypoxia regulation or glucose metabolism, breast cancer stem/progenitor cells demonstrated significant inter-group variability. Breast cancer stem/progenitor cells adapted to microenvironments through changes in stem cell numbers and transcription of glycolytic genes. One of four breast cancer stem/progenitor cells subpopulations exhibited an aerobic glycolysis gene expression signature. This subpopulation comprises the majority of the tumor and therefore best reflects invasive ductal carcinoma tumor biology. Although PI3K/AKT mutations are associated with increased proliferation of breast cancer cells, mutations in breast cancer stem/progenitor cells subpopulations did not correlate with changes in metabolic gene expression.

Conclusions

The adaptive capacity of breast cancer stem/progenitor cells may enable tumors to survive variable conditions encountered during progressive stages of cancer growth.
Global sourcing: new research and education agendas for apparel design and merchandising
Authors: Ha-Brookshire Jung
Published: August 2015

In response to the dominance of global sourcing in the apparel industry within developed economies, this paper illustrates how the topic of global sourcing could help direct agendas for future research and education within the apparel discipline. By reviewing major functions of apparel design, product development, merchandising, and marketing in consideration of global sourcing, this paper shows how global sourcing could help designers and product developers make better decisions of fiber choices, better understand tradeoffs users may make between different raw materials, and become more aware of product performance requirements and design compliance issues. It illustrates how research on global sourcing would help merchandisers become more effective forecasters, planners, and implementers in this highly unpredictable marketplace. Marketing professionals will also learn to work with global sourcers to ensure transparency and integrity of their messages within the legal and ethical frameworks. A discussion on future research questions and educational goals follows.
Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1
Authors: Naval-Macabuhay Isaac , Casanova Víctor , Navarro Gemma , García Felipe , León Agathe , Miralles Laia , Rovira Cristina , Martinez-Navio José M , Gallart Teresa , Mallol Josefa , Gatell José M , Lluís Carme , Franco Rafael , McCormick Peter J , Climent Núria
Published: August 2015

Regulatory T cells have an important role in immune suppression during HIV-1 infection. As regulatory T cells produce the immunomodulatory molecule adenosine, our aim here was to assess the potential of adenosine removal to revert the suppression of anti-HIV responses exerted by regulatory T cells. The experimental setup consisted of ex vivo cocultures of T and dendritic cells, to which adenosine deaminase, an enzyme that hydrolyzes adenosine, was added. In cells from healthy individuals, adenosine hydrolysis decreased CD4+CD25hi regulatory T cells. Addition of 5′-N-ethylcarboxamidoadenosine, an adenosine receptor agonist, significantly decreased CD4+CD25lo cells, confirming a modulatory role of adenosine acting via adenosine receptors. In autologous cocultures of T cells with HIV-1-pulsed dendritic cells, addition of adenosine deaminase led to a significant decrease of HIV-1-induced CD4+CD25hi forkhead box p3+ cells and to a significant enhancement of the HIV-1-specific CD4+ responder T cells. An increase in the effector response was confirmed by the enhanced production of CD4+ and CD8+ CD25−CD45RO+ memory cell generation and secretion of Th1 cytokines, including IFN-γ and IL-15 and chemokines MIP-1α/CCL3, MIP-1β/CCL4, and RANTES/CCL5. These ex vivo results show, in a physiologically relevant model, that adenosine deaminase is able to enhance HIV-1 effector responses markedly. The possibility to revert regulatory T cell-mediated inhibition of immune responses by use of adenosine deaminase, an enzyme that hydrolyzes adenosine, merits attention for restoring T lymphocyte function in HIV-1 infection.
Prism waves in seafloor canyons and their effects on seismic imaging
Authors: Deeks James , Lumley David
Published: August 2015

Complex seafloor bathymetry can create significant challenges for subsurface imaging and geologic interpretation of seismic exploration and monitoring data. Steep seafloor canyons that cut through continental shelf areas can produce very strong seismic wavefield distortions. Neglecting such wavefield complexity can result in inaccurate velocity models, significant imaging errors, misleading amplitudes, and erroneous geologic interpretations. We have evaluated the kinematic and dynamic effects of seismic prism waves generated by seafloor canyons. Prism waves are seismic waves that undergo consecutive reflections at a scattering interface before propagating to the recording sensor array. We have demonstrated that strong prism waves can be generated for realistic seafloor canyon geometries, and we determined how their adverse effects can contaminate seismic imaging and velocity estimation.
Source wavefield reconstruction using a linear combination of the boundary wavefield in reverse time migration
Authors: Liu Shaolin , Li Xiaofan , Wang Wenshuai , Zhu Tong
Published: August 2015

We have developed a new scheme with high accuracy and parsimonious memory requirements to reconstruct the source wavefield in reverse time migration (RTM). This scheme used a linear combination of the boundary wavefield in several layers to reconstruct the wavefield in the imaging domain. The value of the linear combination was stored in one buffer, making the computer memory requirement of our method equal to that of a method that only stored one layer of the boundary wavefield. The coefficients for the linear combination were determined by an optimization technique that minimized the finite difference error in the Fourier domain. The optimal coefficients were presented for finite-difference (FD) stencils of 5–15 grid points. The numerical error of our scheme was analyzed and compared with that of standard FD stencils, representing the conventional method that used multiple layers of boundary wavefield to back propagate the source wavefield. The accuracy of our method is only less accurate than the conventional method in theoretical analysis. However, the storage requirement of our method is merely 1/N of the conventional method if a 2N+1 grid-point FD stencil is used in the space. We have also extended the comparison to two other methods, a one-layer method and an extrapolation method, beyond the conventional method. The numerical results demonstrated that our method can accurately generate high-accuracy images in RTM.
High-resolution ground-penetrating radar profiles of perennial lake ice in the McMurdo Dry Valleys, Antarctica: Horizon attributes, unconformities, and subbottom penetration
Authors: Dugan Hilary A. , Arcone Steven A. , Obryk Maciej K. , Doran Peter T.
Published: August 2015

Ground-penetrating radar (GPR) is not commonly used to study lake ice, and in general, the ground-based use of radar frequencies greater than 500 MHz in cryosphere geophysics is rare, due to a general interest in deeper stratigraphy and the difficulty of extensive profiling over rough snow surfaces. Our goal was to find further information on the origin of the deposition and formation of intra-ice layers, bottom topography, and subbottom deposits using GPR with pulses centered near 850 MHz on two permanently ice-covered lakes in the McMurdo Dry Valleys, Antarctica. The profiles were obtained using a one-person sled operation over Lake Bonney, which is typical of lakes in the region, having an ice thickness that ranges between 3 and 5 m, and Lake Vida, where the maximum ice depth is at least 27 m. Lake Bonney exhibits a semicontinuous sediment horizon at approximately a 2-m depth and several minor horizons. In contrast, Lake Vida contains unconformably eroded and folded continuous reflection horizons, packages of minor horizons between major horizons, evidence of incised fluvial deposition along the bottom, and subbottom penetration of at least 4.5 m in some areas. Where the ice thickness is less than 20 m, the lake is frozen to the bottom. Most horizon waveform phase attributes indicate relatively lower permittivity than in the surrounding matrix. Consequently, we interpreted these strata to be caused by layers of pure ice embedded within a salty and dirty ice matrix, which were formed during minor flooding. These findings supported previous conclusions that Lake Vida ice formed from surface runoff in combination with periods of ablation.
In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine
Authors: Hu Liwei , Xu Wen , Zhang Xi , Su Juan , Liu Xinru , Li Haiyun , Zhang Weidong
Published: August 2015

Objectives

The effects of nuciferine, a major active aporphine alkaloid from the leaves of Nelumbo nucifera Gaertn, on a cytochrome P450 1A2 (CYP1A2) probe substrate were investigated in vitro and in vivo.

Methods

Nuciferine and recombinant human CYP1A2 were incubated together to study the impact of nuciferine on CYP1A2 in vitro. Nuciferine was administered orally to Wistar rats at a dose of 20 mg/kg to further estimate the impact of nuciferine on CYP1A2 in vivo. A probe substrate, phenacetin, was used to index the activity of CYP1A2.

Key findings

The IC50 value for nuciferine was determined to be 2.12 mmol/l. When phenacetin was intravenously coadministered with nuciferine compared with phenacetin alone, the elimination rate constant and total body clearance of phenacetin were decreased by 24.0% (P < 0.01) and 43.0% (P < 0.05), respectively. The mean residence time, apparent elimination half-time and area under the plasma concentration–time curve were increased by 22% (P < 0.005), 26.9% (P < 0.02) and 74.6% (P < 0.05), respectively. Similarly, when phenacetin was coadministered orally with nuciferine, the apparent elimination half-time in the nuciferine pretreated group was increased by 16.7% (P < 0.05) and the elimination rate constant was decreased by 15.4% (P < 0.05).

Conclusions

The results suggest that nuciferine inhibited CYP1A2 activity in vitro and caused changes in the pharmacokinetic parameters of phenacetin in vivo.
Reflections on Skepticism in Homer'sOdysseyand the Poetry of C.p. Cavafy
Authors: Zerba Michelle
Published: August 2015

This essay reads Homer's Odyssey alongside several poems by the Greek-Alexandrian writer C.P. Cavafy who, although widely removed from the epic in time, shares a common geographical imaginary located in the Mediterranean and explores questions of cultural identity, memory, and gender in ways that resonate with the Odyssey's own preoccupations. The conceptual framework used to bring these poets into dialogue draws from ancient skepticism as a posture or way of being in the world that shapes philosophical and literary works bound up in what the Pyrrhonists called “the searching way.”
The case of philanthropy: bringing scientists and philanthropic donors together, for good
Authors: Flatto Olivia Tournay
Published: August 2015

Summary: Philanthropists and scientists share many common interests, and yet they are not familiar with each other's ways of thinking. This Editorial highlights how to improve their mutual understanding to advance research and life sciences.
A Tunable Superwetting Copper Film between Superhydrophobicity and Superhydrophilicity
Authors: Yan Ningbo , Li Jing , Guo Zhiguang , Xu Jiansheng
Published: August 2015

In this paper, it was intriguing to discover that drying condition played an important role in the superwettability properties of the copper film. Importantly, we successfully realized the unique copper film with reversible superwettabilities by solution stimulation, which can be employed as a kind of new engineering intelligent switchable material.
The role of connective tissue in the embryology of the musculoskeletal system: towards a paradigm shift
Authors: Marchuk Carolina , Stecco Carla
Published: August 2015

This paper presents a review of literature regarding the role of embryological connective tissue in the formation of muscles and the organization of the musculoskeletal system. The intention is to introduce a potential paradigm shift with regards to understanding peripheral coordination of movement and movement patterns. This new perspective could improve comprehension of the normal physiological function of connective tissue and, whenever it is pathological, resultant symptoms. Furthermore, this paper briefly discusses some implications of this paradigm shift in the interpretation of movement patterns, posing further questions for future research.
Evaluation of tourist resources and tourism infrastructure quality in municipalities
Authors: Ульяниченко Людмила , Ulyanichenko Lyudmila , Минаев Владимир , Minaev Vladimir , Цыщук Евгений , Tsyshchuk Evgeniy
Published: August 2015

The article examines the questions of informational and methodological support of the assessment procedures and analysis of the benefits and risks of tourism development at the municipal level. The information, obtained by expert, is described. It includes monuments; farms and estates; religious sites – churches, temples, cathedrals and monasteries; memorial sites and places of military glory; objects of natural reserve Fund (NRF); beach areas and places of recreation; hunting and fishing sites; museums, museums-reserves, exhibition halls; industrial, agricultural enterprises and organisations that have already become the objects to show or have the potential to become; folk arts and crafts. Assessment objectives of tourism infrastructure in the settlements are associated with the analysis of the state of accommodation facilities, catering, entertainment and Park recreation areas. The method for the quantitative evaluation of the attractiveness of tourism resources and the quality of the tourist infrastructure of municipalities on the basis of expert procedures is described. The technique is approved on the settlements of the Klin district. Quantitative indicators of comprehensive assessment of the attractiveness of tourism resources and the quality of tourist infrastructure are introduced and experimentally approved, as well as indicators of settlements on these characteristics are generalized. The results of the ranking of settlements in the district are described on summary measures. There are proved two possible strategies for development of tourism in the region: extensive, according to which resources are directed towards the development of tourism in accordance with the obtained grades that will allow to achieve a relatively quick economic effect with respect to the settlements with higher grade, however, will slow the development of tourism in settlements with low grades; system – in accordance with existing territorial differences in the distribution of tourist resources and tourist infrastructure zoning district is realized to strengthen the weak areas at the expense of well-developed tourist areas.
Using Fuzzy Logic Analysis in GIS and FAHP Method for Parks Site Selection in Urban Environment (Case Study: Region 7, Tehran Municipality)
Authors: Givi Amin
Published: August 2015

The overall goal of this research is to determine the importance of affecting factors for site selection in parks and urban green spaces and also a suitable site selection for parks in the study area. Methodology of this research is an analytic descriptive research. At first by using library and literature review and Delphi approach effective parameters in site selection of parks were extracted and then, pair wise comparison performed in FAHP method with relevant experts to determine significance and weighted of criteria. Then, data layers standardized in IDRISI software and were prepared in the form of Fuzzy. And finally prepared Fuzzy maps overlaid in GIS software by considering their weights to identify suitable locations for the construction of parks in region 7 of Tehran municipality.
Dispersion Pattern of Native Species in Sal Forests of Chhotanagpur Plateau, India
Authors: Narayan Chandravir , Anshumali Anshumali
Published: August 2015

Changes in the dispersion pattern of native tree species were studied in Sal forests of Chhotanagpur plateau by selecting 1 hectare (ha) plot at four sites, located 2 to 10 km apart from each other. Each plot was divided into 100 quadrats each of 10 m x 10 m in size. For each 10 m x 10 m quadrat, the number of species and density of adult trees (>30 cm circumference at breast height: 1.37 m) were measured and identified. The range of uniform dispersion (77-89%) was greater than clumped dispersion (6-19%) and random dispersion (4-8%) in all four sites. About 78% of the plant species were characterised by uniform dispersion indicating dominant ecological reaction (i.e. dispersion behaviour) in response to alterations in the habitat conditions. A greater part of quadrats had 1-3 species and 1-4, 5-8 and 9-12 individuals indicating a patchy habitat with poor species richness and density at each site, a characteristic of the highly disturbed Sal forests.
Ecosystem Health of Lake Tamrangabeel, Bongaigaon District, Assam, India with Special Reference to Aquatic Insect Assemblage
Authors: Bhagawati R. R , Gupta Susmita
Published: August 2015

This study investigated the ecosystem health of a floodplain lake, Tamrangabeel of Bongaigaon district, Assam, India using aquatic insects as bioindicator. The aquatic community of Tamrangabeel was represented by 37 species belonging to 19 families and 5 orders. Shannon –Wiener diversity index (Shannon Hꞌ) values were recorded less than 1 in all the sites of the lake which indicated perturbed condition of the lake. Order Hemiptera was found to be the largest order with highest number of species. Eudominant species recorded in this lake were Micronecta siva (order Hemiptera) and Cloeon sp. (order Ephemeroptera). Biological Monitoring Working Party (BMWP) Score, Average Score per taxon (ASPT), and Stream Invertebrate Grade Number-Average Level (SIGNAL) Score reported from the study reflected good ecological potential as well as slightly impacted nature of the water body. The values of different environmental variables of water of all the sites of the lake were found conducive for aquatic life. This study provided an early warning of perturbation of the lake which is to be addressed before it is too late.
The CQC and safeguarding: the impact on dental nurses
Authors: Hancock Dave
Published: August 2015

Following new legislation, the Care Quality Commission published a statement on its roles and responsibilities for safeguarding children and adults in England. Dave Hancock considers the likely impact on dental nurses
Neuropathic pain in people with cancer (part 2): pharmacological and non-pharmacological management
Authors: Taverner Tarnia
Published: August 2015

The aim of this paper is to provide an overview of the management of neuropathic pain associated with cancer and to provide helpful clinical advice for nurses working with patients who may have neuropathic pain. While cancer pain is a mixed-mechanism pain, this article will focus only on neuropathic pain management. The impact of neuropathic pain on patients' quality of life is great and while many patients recover from their cancer, a significant number continue to suffer from a neuropathic pain syndrome. Management of neuropathic pain is significantly different from management of nociceptive pain with respect to pharmacological and non-pharmacological strategies. Neuropathic pain is complex, and as such requires complex management using pharmacological as well as non-pharmacological approaches. Specific drugs for neuropathic pain may be effective for some patients, but not all; therefore, ongoing and comprehensive assessment and management are required. Furthermore, these patients may require trials of several drugs before they find one that works for them. It is important for nurses to understand neuropathic pain, its manifestation, impact on quality of life and management when nursing patients with neuropathic pain associated with cancer.
A Japanese booklet about palliative care for advanced dementia in nursing homes
Authors: Nakanishi Miharu , Miyamoto Yuki , Long Carol O , Arcand Marcel
Published: August 2015

Background

A Canadian guide for nursing home staff on comfort care for dementia has been translated and adapted for use in Japan. The present study piloted educational intervention for nursing home staff using the Japanese comfort care booklet.

Method

Some 61 nursing home staff (nurses and other care workers) completed a session that included pre-assessment, a 30-minute seminar using the comfort care booklet, post-assessment, and a one-hour debriefing meeting. A Japanese version of the questionnaire on palliative care for advanced dementia (qPAD) scale was used to assess knowledge and attitudes toward palliative care for advanced dementia.

Results

The participants demonstrated a significant increase in knowledge (mean score, 14.3 to 15.1/23, t (60) = 2.35, p=0.011) and attitudes (43.8 to 45.2/60, t (60) = 2.51, p = 0.015) toward palliative care for advanced dementia from pre-assessment to post-assessment.

Conclusion

The educational intervention using the Japanese comfort care booklet may have improved nursing home staff's perspectives on palliative care for advanced dementia.
Research roundup
Authors: Costello John
Published: August 2015

Synopses of a selection of recently published research articles of relevance to palliative care.
Polluting the Waters: A Brief History of Anti-Communist Propaganda during the Indonesian Massacres
Authors: Henry Adam Hughes
Published: August 2015

In response to an alleged Communist coup in Indonesia on 1 October 1965, ambassadors Sir Keith Shann (Australia), Sir Andrew Gilchrist (United Kingdom), and Marshall Green (United States) initiated anti-Communist propaganda campaigns. In conjunction with the Indonesian army, these campaigns helped to underpin the rationale for widespread, army-coordinated anti-Communist repression throughout Indonesia. Through a careful re-examination of Australian archival materials regarding Indonesia between October 1965 and February 1966, this article provides a detailed, transnational chronology of propaganda efforts during the period of the massacres, highlighting the direct and indirect connections between them and the killings.
Examining the contribution of social media in reinforcing political participation in Zimbabwe
Authors: Mutsvairo Bruce , Sirks Lys-Anne
Published: August 2015

It normally is assumed that new media activism, in the wake of the ‘Arab Spring’ political protests in the Middle East, has the potential to promote and effectively enable social and political changes in contemporary societies. However, nowhere does the influence of the digital explosion appear somehow exaggerated as in the case of Africa, where lack of empirical evidence has seen policy-makers, commentators and journalists making extraordinary conclusions justifying the Internet’s perceived potential to shape political processes on the continent. This article questions this notion through an online ethnographic assessment of Zimbabwean blogger Baba Jukwa’s Facebook webpage, which became a prominent platform for the anti-Robert Mugabe establishment up until its sudden withdrawal from the web in August 2014. At its peak, the webpage became a meeting point for activists opposed to Zimbabwe’s long-time president as the anonymous blogger shared what he (assuming he was a man) claimed were juicy state secrets with the rest of the world. His pronouncements especially ahead of the 2013 elections gave hope to opposition campaigners that the era of a man, who has ruled Zimbabwe since 1980, was coming to an abrupt end. Calls were then made suggesting that the presence of the historic page was buttressing democratic participation as Zimbabweans from across the world converged on the blog discussing issues of mutual interest. The findings of our research, however, give a different picture, concluding rather that in spite of the page’s ability to encourage Zimbabweans to openly discuss and share thoughts, there simply is no evidence that Baba Jukwa had helped facilitate increased democratic participation in the country.
Book review
Authors: Lopang Wazha
Published: August 2015

Why I Did n’t Kiss Tatiana, J. S. Motlhabani (2013) Gaborone: self published by J.S Motlhabani, ISBN: 9789996800092, p/bk, no price listed. 168 pp.
Review
Authors: Stansbie Adam
Published: August 2015

Soundweaving: Writings on Improvisation, Franziska Schroeder and Mícheál Ó Haodha (eds) (2014) Cambridge Scholars Publishing, Newcastle Upon Tyne, hardback, ISBN-13: 9781443853446; ISBN-10: 1443853445; £39.99
The making of cooperation
Authors: Panagiotara Betina
Published: August 2015

This article explores the terms “collaboration” and “cooperation” as practices, through the examination of the project Syros: A bet on the potentiality of cooperation, which took place in Syros, Greece, in July 2013. In particular, it describes the process of cooperating in practical terms and reflects on the conditions of production created by the project. For this purpose, it focuses on two of its essential components: namely, the structure of the project and the space of encounters it generated. The aim is to contribute to larger discussions on collaborative artistic practices through disclosing and studying the dynamics detected in a specific case study.
In memoriam: Petra Veber Rojnik (1972-2015)
Authors: Lah Jaka
Published: August 2015

As an actress, Petra Veber Rojnik created a number of unforgettable roles, in both institutional and non-institutional theatre projects. She drew the attention of the theatre public very early on, at the very beginning of her creative path, when she astonished with a series of experimental projects created within the collective of the E.P.I. Centre cultural and production institute and marked by an exploratory élan and a fresh, uncompromising aesthetics.
Resistance against aestheticisation of resistance
Authors: Jelesijević Nenad
Published: August 2015

Through an analysis of a well-publicised intervention into the exhibition Socialdress – Power to the People in October 2013 at the Alkatraz Gallery, which operates within Autonomous Cul¬tural Centre Metelkova City in Ljubljana, the article argues that mainstream artwork cannot stay sheltered from protest (re)ac¬tions solely thanks to the fact that it is part of the hegemony of the art system. Namely, in the context of the movement towards increasingly radical capitalist devastation, a link is established between numerous manifestations of resistance, including the protest against the commodification of popular uprisings’ slogans, which opens up the perspective of understanding art as a phenomenon without the status of difference, which would grant it any kind of privilege.
Keep on asking, betting, cooperating: Introduction
Authors: Georgelou Konstantina , Protopapa Efrosini , Theodoridou Danae
Published: August 2015

The editorial note unfolds the main aims and the particular working conditions of the project that has led to the specific publication. Syros: a bet on the potentiality of cooperation (2013) was organized as a co-writing encounter among performance artists and theorists from all over Europe. During an eight-days long writing residency the participants shared their individual topics of interest regarding contemporary performance as well as their distinct writing practices. Following that process, they also suggested an alternative mode for the creators of this publication, based not on a common topic (as is often the case) but on the “topos”, the place of encounter of its writers, which is seen as a “bet on the potentiality of cooperation” (Laermans).
Nostalgia for the present: Historical time in there contemporary performances
Authors: Cate Floor Houwink ten
Published: August 2015

The essay discusses how The Artist Is Present (2010) by Marina Abramović, The Show Must Go On (2001) by Jérome Bel and The Happiest Man (2000) by Ilya and Emilia Kabakov relate to the ‘nostalgia for the present’ of European and North American late capitalist societies of the spectacle. The works are firstly explored through the ways in which the artists “stage the present” by manipulating the presence and liveness of both themselves and their spectators, and secondly, how these “stagings of the present” consequently influence one’s perception of duration and the passage of time.
Technoetic space at risk: The development of a hybrid ecology framework for the spatial (re)configuration of the human condition
Authors: Smith Carl H.
Published: August 2015

Hybrid techniques and perceptual technologies that merge the physical and the virtual dimensions of reality are generating a conceptual and experiential working space to reconfigure relationships between the perceiver and the perceived. We are entering a new perceptual paradigm where form, content, and context are merging, generating radical new types of spatial construction.

Through the development of hybrid spatial technologies we can now hack the individual’s sense of space and relationship to the world (transforming the subject/object relationship). How can we develop and use emerging spatial technologies to reconfigure spatial perception? Can we adapt and transform the dominant perceptive regimen, which is still based on the Cartesian split (subject-object separation)? We continue to see ourselves as separated from the environment and still need to digest the new changes brought about by hybrid techniques and methodologies that are shaping these new dimensions of space. How adaptable is our perception? The ability to alter our understanding of space provides us with a new form of spatial (self) control; sub-merging identities. What are the biological risks? What are the limits of stretching the perceptive range of the body?

This article will examine these questions as an opportunity to humanise technology and create a ‘Human Centric Hybrid Literacy’. We will examine which technologies, techniques and navigation methodologies are being used by artists, technologists and designers to enable this new era of spatial augmentation and perceptual adaptation. Some examples include macroscopic navigation, 360 degree vision, new types of perspective (including third and fourth person perspectives) and reverse engineering.

The role that hybrid space plays in the construction and transformation of perception through the practice of context engineering will be examined. Context engineering (Smith, 2013) is understood as an ‘intermediality’ practice for the engagement and augmentation of perception; giving us control over our senses, allowing us to adjust them in real time. Context engineering creates a new economy where we focus less on transforming content (as the primary activity), and more on how we can make our own perception the ‘content’.
Comportamento fluência-recuperação de ligantes asfálticos modificados com copolímero SBR e ácido polifosfórico
Authors: Inocente Domingos Matheus David , Faxina Adalberto Leandro
Published: August 2015

Este trabalho avaliou os comportamentos fluência-recuperação de ligantes asfálticos modificados com o copolí-mero SBR (CAP+SBR), ácido polifosfórico (CAP+PPA) e uma combinação de ambos (CAP+SBR+PPA) por meio do ensaio de fluência e de recuperação sob tensão múltipla (MSCR) em temperaturas entre 52 e 76 °C. Todas as formulações apresen-tam a mesma classificação em temperaturas altas (PG 76-xx) e o CAP 50/70 é classificado como PG 64-xx. Aumentos no percentual de recuperação (R) e reduções na compliância não-recuperável (Jnr) foram observados após os processos de mo-dificação, o que é favorável à resistência do CAP à deformação permanente. Os níveis recomendados de tráfego se mostraram semelhantes para o CAP+SBR+PPA e para o CAP+PPA, sendo também maiores do que aqueles encontrados para o CAP+SBR. Isto indica que o PPA tem potencial para substituir o uso do SBR na modificação do CAP, desde que a formulação não apresente uma suscetibilidade excessiva ao trincamento por fadiga e ao trincamento térmico.
Custos de reciclagem de pavimentos de concreto e seu potencial econômico na realidade brasileira
Authors: Balbo José Tadeu , Dorneles Ricardo Cruvinel
Published: August 2015

Os custos de produção de agregados reciclados de concretos de antigos pavimentos devem ser contextualizados nas obras de pavimentação rodoviária no país. Valores fornecidos em tabelas de serviços para vias urbanas podem não refletir as condições específicas da demolição em rodovias. Também, preços operados em outros países são afetados pela tecnologia de reciclagem empregada, que não é aquela que tem sido considerada no Brasil. Neste artigo são determinadas as razões unitárias de produção relacionadas à demolição, carga, transporte e britagem de pavimentos de concreto removidos de pistas de duas rodovias brasileiras. Com base nos resultados pôde-se verificar um acréscimo de 50% no custo final do agregado reciclado em relação ao agregado virgem, resultando em acréscimo de cerca de 20% nos custos de produção de concretos para pavimentação. O potencial brasileiro de produção desses agregados reciclados a partir de pavimentos de concreto deteriorados é limitado o que pode ser um fator estagnante para o emprego da tecnologia no país.
Taxa de geração de viagens para instituições privadas de ensino superior: estudo de caso para a cidade de Uberlândia-MG
Authors: Paula Ana Flavia Ferreira de Castro , Sorratini José Aparecido , Silva Thays Pereira , Nogueira Maria Amélia Mangussi , Silva Ana Carolina Souza
Published: August 2015

O objetivo deste estudo foi estimar as taxas de geração de viagens para modos de transporte motorizado e não motorizado, utilizados por alunos, professores e funcionários de instituições privadas de ensino superior na cidade de Uber-lândia, Minas Gerais. Foi possível estimar as taxas somente para alunos e no turno noturno. As taxas médias de atração/pro-dução obtidas para os modos de transporte automóvel, a pé, motocicleta, ônibus urbano, ônibus interurbano e van, foram, respectivamente de 0,280/0,283; 0,005/0,006; 0,180/0,179; 0,335/0,316; 0,093/0,103 e 0,050/0,063. No que diz respeito ao coeficiente de variação, para os modos de transporte automóvel e ônibus urbano, os valores percentuais para atração/produ-ção, foram respectivamente de 13,23/11,44 e 20,53/25,19, indicando boa precisão dos resultados obtidos. Para os demais modos de transporte estudados, a pé, motocicleta, ônibus interurbano e van, o coeficiente de variação ficou entre 38,11% e 70,71%, indicando baixa precisão na determinação das taxas de geração de viagens.
Análise do comportamento mecânico de um pavimento reciclado com adição de diferentes agentes estabilizadores
Authors: Dalla Rosa Francisco , Jorge Fabiano Da Silva , Brito Lélio Antônio Teixeira , Ceratti Jorge Augusto Pereira
Published: August 2015

Este trabalho apresenta um estudo do comportamento mecânico de um pavimento reciclado com adição de dois agentes estabilizadores. O material de estudo, foi coletado junto à BR-116 próximo ao município de Pelotas/RS, é resultado da trituração do revestimento e parte da base. Utilizou-se o cimento Portland e uma emulsão asfáltica como agentes melhoradores de desempenho mecânico da mistura. Foi avaliado o comportamento mecânico da mistura sem os aditivos, e posteriormente com a adição de cada um deles. Os resultados apontaram que a adição de cimento Portland promoveu considerável acréscimo do Módulo de Resiliência (MR), e que esse valor teve um pequeno decrescimento com a adição da emulsão asfáltica. Por outro lado, a adição somente de emulsão asfáltica promoveu pequeno acréscimo do valor do MR triaxial, mostrando-se assim uma mistura mais dúctil em relação às misturas que continham cimento Portland.
Nach dem Primitivismus?
Authors: Wienand Kea
Published: August 2015

Die im Nationalsozialismus als »entartet« diffamierte Kunst, die auf vermeintlich »primitive Kulturen« referiert, galt in der Bundesrepublik Deutschland als »antifaschistisch«, ohne dass deren Kolonialrassismen reflektiert wurden. Wie aber wurde kulturelle Differenz in der Kunst der Bundesrepublik von 1960 bis 1990 verhandelt? Kea Wienand diskutiert, inwiefern KünstlerInnen wie Joseph Beuys, Sigmar Polke, Ulrike Rosenbach u.a. nach 1960 einen Primitivismus fortgeführt, verändert oder kritisiert haben. Sie zeigt auf, wie über Bilder von kultureller Differenz Vorstellungen von Künstlerschaft, Sexualität, Geschlecht und Geschichte thematisiert werden.
Negative association between paraoxonase 2,
anthropometric markers and metabolic syndrome
Authors: Mihai Andrada , Lixandru Daniela , Alexandru Petruta , Stoian Irina , Carniciu Simona , Mitu Manuela , Guja Cristian , Ionescu-Tirgoviste Constantin
Published: August 2015

Background Metabolic syndrome (MS) has a great
impact on cardiovascular mortality and morbidity. Our aim
was to investigate the association of MS with some oxidant
and antioxidant markers, including pro-and antioxidant
status of peripheral blood mononuclear cells (PBMC) in
newly diagnosed type 2 diabetic mellitus patients (ND-T2D).
Methods 219 ND-T2D and 88 healthy subjects were divided
in two groups according to the absence or presence
of MS. Anthropometric measurements, routine blood
tests, total oxidant status (TOS), total antioxidant status
(TAS) and ELISA measurements were included. The
PBMC capacity to release free radicals and to neutralize
them was also determined by measuring the respiratory
burst (RB) together with the lactonase activity of the
intracellular antioxidant enzyme paraoxonase 2 (PON2).
Results Comparing ND-T2D MS+ with those MS- the RB of
the PBMC was significantly higher (p<0.05) while lactonase
PON2 enzymatic activity was decreased (p < 0.001). A
negative correlation of RB was found with TAS (r = -0.416, p
< 0.05). PON2 was also negatively correlated with glycaemia
(r = -0.275, p < 0.001), HbA1c (r = -0.308, p < 0.001), weight
(r = -0.183; p < 0.05), waist circumference (r = -0.353,
p < 0.001) and body mass index (r = -0.290, p < 0.001).
Conclusion PON2 lactonase activity is negatively associated
with anthropometric markers in ND-T2D with MS.
Use of ZSM-5 catalyst in deoxygenation of waste cooking oil
Authors: Lovás Peter , Hudec Pavol , Hadvinová Marcela , Ház Aleš
Published: August 2015

This study investigated the potential use of waste cooking oil (WCO) in the production of engine fuels and valuable chemicals via catalytic cracking. WCO was processed in its pure form and in a mixture with hydrotreated vacuum gas oil (HVGO). Catalytic cracking experiments were performed using a microactivity test (MAT) (simulation of the fluid catalytic cracking environment). In cracking over the standard fluid catalytic cracking equilibrium catalyst (FCC-ECAT), the oxygen contained in the feed was consumed in the formation of CO and CO
Ce(III) immobilised on aminated epichlorohydrin-activated agarose matrix – “green” and efficient catalyst for transamidation of carboxamides
Authors: Zarei Zeinab , Akhlaghinia Batool
Published: August 2015

The present study reports the preparation and characterisation of Ce(III) immobilised on an aminated epichlorohydrin-activated agarose matrix (CAEA) as a “green” catalyst. The catalyst was synthesised by the reaction of the epichlorohydrin-activated agarose matrix with ammonia solution, which was then treated with Ce(NO
An Adaptive Wavelet Method for Semi-Linear First-Order System Least Squares
Authors: Chegini Nabi , Stevenson Rob
Published: August 2015

We design
an adaptive wavelet scheme for solving first-order system least-squares formulations of second-order elliptic PDEs that converge with the best possible rate in linear complexity.
A wavelet Riesz basis is constructed for the space

H
→

0
,

Γ
N

(
div
;
Ω
)

$\vec{H}_{0,\Gamma _N}(\operatorname{div};\Omega )$

on general polygons. The theoretical findings are illustrated by numerical experiments.
Genesis of ER stress in Huntington’s Disease
Authors: Shenkman Marina , Eiger Hagit , Lederkremer Gerardo Z.
Published: August 2015

Recent research has identified ER stress as a major mechanism implicated in cytotoxicity in many neurodegenerative diseases, among them Huntington’s disease. This genetic disorder is of late-onset, progressive and fatal, affecting cognition and movement. There is presently no cure nor any effective therapy for the disease. This review focuses on recent findings that shed light on the mechanisms of the advent and development of ER stress in Huntington’s disease and on its implications, highlighting possible therapeutic avenues that are being or could be explored.
The origin of native selenium microparticles during the oxidation of sideritic mudstones in the Veřovice Formation (Outer Western Carpathians)
Authors: Matýsek Dalibor , Skupien Petr
Published: August 2015

Microparticles of native selenium were detected in weathered sideritic mudstones of the Veřovice Formation (Aptian) of the Silesian Unit (Outer Western Carpatians, NE part of the Czech Republic). This mineral forms small needle-like crystals with lengths of up to 20 μm, and is confined to fissures in sideritic mudstones covered by goethite or rarely also by hydrated Mn-oxide minerals. The oxidized sideritic mudstones show zonal structure and resemble the initial stage of the formation of the so-called rattle stones. From the superposition of phase diagrams of selenium and Fe-oxyhydroxides, Fe apparently occupies a large field in which Se(0) and FeOOH and/or Fe(OH)3 can co-exist. The reduction of selenites or selenates by pyrite or by any other phase, capable of charge transfer, is likely to have been responsible for the formation of microparticles of native selenium. The crucial factor controlling the origin of these particles is the extremely low solubility of Se(0). The source of Se is not obvious. It can be released in trace concentrations during the weathering of pyrite. Sediments of the Veřovice Formation correspond to the anoxic event OAE1b and accumulation of siderophile elements in similar sediments is very probable. A probable mechanism for the origin of Se microcrystals is gradual crystallization from solution.
Turbidites as indicators of paleotopography, Upper Miocene Lake Pannon, Western Mecsek Mountains (Hungary)
Authors: Sztanó Orsolya , Sebe Krisztina , Csillag Gábor , Magyar Imre
Published: August 2015

The floor of Lake Pannon covering the Pannonian Basin in the Late Miocene had considerable relief, including both deep sub-basins, like the Drava Basin, and basement highs, like the Mecsek Mts, in close proximity. The several km thick lacustrine succession in the Drava Basin includes profundal marls, basin-center turbidites, overlain by shales of basin-margin slopes, coarsening-upward deltaic successions and alluvial deposits. Along the margin of the Mecsek Mts locally derived shoreface sands and deltaic deposits from further away have been mapped so far on the surface. Recent field studies at the transition between the two areas revealed a succession that does not fit into either of these environments. A series of sandstone a few meters thick occurs above laminated to bioturbated clayey siltstone. The sandstone show normal grading, plane lamination, flat erosional surfaces, soft-sediment deformations (load and water-escape structures) and sharp-based beds with small reverse faults and folds. These indicate rapid deposition from turbidity currents and their deformation as slumps on an inclined surface. These beds are far too thick and may reveal much larger volumes of mass wasting than is expected on the 20–30 m high delta slopes; however, regional seismic lines also exclude outcropping of deep-basin turbidites. We suggest that slopes with transitional size (less than 100 m high) may have developed on the flank of the Mecsek as a consequence of lake-level rise. Although these slopes were smaller than the usually several hundred meter high clinoforms in the deep basins, they could still provide large enough inertia for gravity flows. This interpretation is supported by the occurrence of sublittoral mollusc assemblages in the vicinity, indicating several tens of meters of water depth. Fossils suggest that sedimentation in this area started about 8 Ma ago.
Nomenclature Adjustments and New Syntaxa of the Arctic, Alpine and Oro-Mediterranean Vegetation
Authors: Chytrý Milan , Danlëls Fred J. A. , Di Pietro Romeo , Koroleva Natalia , Mucina Ladislav
Published: August 2015

During preparation of the European checklist of vegetation units (EuroVegChecklist), it became clear that some earlier described syntaxa need to be typified in order to stabilize nomenclature and some new syntaxa need to be described. Here we propose nomenclature adjustments and formal description of four new alliances for the Arctic, alpine and oro-Mediterranean vegetation of Europe, Greenland and Anatolia. First, we typify the class Juncetea trifidi. Second, we describe four new alliances, such as the Puccinellion nuttallianae (Low-Arctic salt steppes of Greenland; class Saxifrago tricuspidatae-Calamagrostietea purpurascentis), Dryado octopetalae- Caricion arctisibiricae (Arctic tundra vegetation of north-eastern European Russia; class Carici rupestris- Kobresietea bellardii), Leontopodio nivalis-Elynion myosuroidis (southern European alpine tundra vegetation; class Carici rupestris-Kobresietea bellardii) and Lagotido uralensis-Caricion ensifoliae (alpine tundra vegetation of the Southern Ural Mountains; class Juncetea trifidi). Two new associations are described within the first two of these alliances. Finally, we present an interpretation of the alliance Muscario-Scillion nivalis.