bluuebunny/crossref_metadata_2025 huggingface dataset:
Participación Política de las Mujeres en el Gobierno Escolar. Estudio de caso de la Institución Educativa Los Uvos (Municipio De La Vega, Cauca, Colombia)
Authors: Girón Hurtado Roxsana Maryoli , Ortiz Gordillo Andrés Felipe
Published: January 2025

El artículo analiza el proceso de participación política de las mujeres en los espacios del gobierno escolar de la Institución Educativa Los Uvos, ubicada en el municipio de La Vega, Departamento del Cauca, Colombia. A partir de un estudio de caso, se busca establecer las relaciones de género en los procesos de participación de las estudiantes de los grados noveno, décimo y undécimo, y su incidencia en la cultura política de la Institución Educativa, para proyectar estrategias de empoderamiento de las jóvenes, pues se entiende que la participación política es un campo de interés central en los procesos formativos contemporáneos. Como resultado de un proceso de co-teorización, en el que las estudiantes propusieron categorías de análisis para abordar el problema de la participación política en la Institución Educativa, se concluye que los niveles de participación política de las mujeres son inferiores a los de los hombres; en esto influyen factores como el carisma, la falta de proyección de las mujeres como actores claves en los procesos de deliberación de los asuntos públicos inherentes al proceso formativo integral y la exclusión histórica de las mujeres de los ámbitos institucionales de deliberación público política. Frente a este contexto, se identifica que las estudiantes cuentan con una vocación política que se expresa mediante dispositivos y escenarios de liderazgo no institucionalizados, que van más allá de los espacios formales destinados institucionalmente a la participación política, los cuales adquieren una impronta más social.
Designing open quantum systems with known steady states: Davies generators and beyond
Authors: Guo Jinkang , Hart Oliver , Chen Chi-Fang , Friedman Aaron J. , Lucas Andrew
Published: January 2025

We provide a systematic framework for constructing generic models of nonequilibrium quantum dynamics with a target stationary (mixed) state. Our framework identifies (almost) all combinations of Hamiltonian and dissipative dynamics that relax to a steady state of interest, generalizing the Davies’ generator for dissipative relaxation at finite temperature to nonequilibrium dynamics targeting arbitrary stationary states. We focus on Gibbs states of stabilizer Hamiltonians, identifying local Lindbladians compatible therewith by constraining the rates of dissipative and unitary processes. Moreover, given terms in the Lindbladian not compatible with the target state, our formalism identifies the operations – including syndrome measurements and local feedback – one must apply to correct these errors. Our methods also reveal new models of quantum dynamics: for example, we provide a “measurement-induced phase transition” in which measurable two-point functions exhibit critical (power-law) scaling with distance at a critical ratio of the transverse field and rate of measurement and feedback. Time-reversal symmetry – defined naturally within our formalism – can be broken both in effectively classical and intrinsically quantum ways. Our framework provides a systematic starting point for exploring the landscape of dynamical universality classes in open quantum systems, as well as identifying new protocols for quantum error correction.
Analysis of financial distress factors in the mining industry: Empirical study of the developing market
Authors: Movsesyan Satik , Seissian Lena A.
Published: January 2025

Bankruptcy and financial distress studies have been among the most intensively researched topics starting from the 1960s, being pioneered by Edward Altman, deploying accounting ratios for assessing the financial healthiness of companies. This research deploys financial, macroeconomic, and company-specific factors to check the movement of a company’s classification of financial health. Deploying a generalized ordered logit model on the sample of 11 mining companies listed on the Lima Stock Exchange (Bolsa de Valores de Lima — BVL) we revealed a significant impact of leverage, profitability, economic growth, company size and interest rates on the probability of company staying in or moving from one of three financial health groups. The study finds that borrowing costs significantly impact corporate financial distress, with Peruvian mining companies being naturally protected against adverse interest rate fluctuations reflecting their hedging ability. The findings of this research expand the current body of literature review and are consistent with results presented by Sierpińska (2021), Van et al. (2021), and Boďa and Úradníček (2016).
An evaluation of the scapular osseous free flap in maxillary reconstruction using the FACE-Q Head and Neck Cancer Module for patient-reported outcome measures
Authors: Guné Henrik , Sjövall Johanna , Becker Magnus , Klasson Stina
Published: January 2025

Introduction: Health-related quality of life (HR-QoL) outcomes following maxillary reconstruction with the scapular osseous free flap (SOFF) are lacking. 
Material and Methods: To determine these outcomes, a study of patients who completed maxillary reconstruction with flap survival of the SOFF between 2016 and 2023 was conducted, using Face-Q Head and Neck Cancer Module (FACE-Q).
Results: Eligible patients had at least six months of follow-up. Twenty questionnaires were completed (100% response rate). Median age was 59 years, 80% were male, and 90% were being treated for malignant disease. Overall, best scores were reported in the facial appearance and experience of care domain. Furthermore, the worst scores were reported in the facial function domain. Subgroup analysis focused on the following three specific surgical outcomes; dental rehabilitation, oronasal fistula and eye-related problems. A better score, though non-significant, in facial function was recorded in the dental rehabilitation group, (70±23 vs. 40±34, p = 0.089). A tendency towards worse facial function regarding eating and drinking was noted in the fistula group (49±14 vs. 56±23, p = 0.468). Patients suffering from eye-related problems reported marginally worse facial appearance scores, (79±21 vs. 68±19, p = 0.289). Conclusion: In 20 patients who completed maxillary reconstruction with flap survival of the SOFF, the group reported the best scores in the facial appearance and experience of care domain.
FEATURES OF POSTTRAUMATIC GROWTH IN WOMEN WITH MALIGNANT NEOPLASMS OF THE REPRODUCTIVE SYSTEM
Authors:   Ryazan State Medical University, Trusova A. D. , Ilyina P. I. ,   Ryazan State Medical University
Published: January 2025

Relevance of research is determined by the absence at the moment of a unified and ambiguous concept
about the manifestations of post-traumatic growth in patients with malignant neoplasms of the
reproductive system in Russian psychology. Most studies of patients in this group are devoted to the
study of the relationship between cancer and psychopathology, in particular, post-traumatic
stress disorder, adaptation disorders. The empirical study involved 60 women with oncological diseases of the reproductive system (ovarian cancer, cervical cancer), with the mean age 41 years. The empirical study was conducted on the basis of the Ryazan Regional Clinical Oncology Dispensary. The following methods were used: 'Post-traumatic Growth Questionnaire' adapted by M. Sh. Magomed-Eminov, 'Resilience Test' adapted by D. A. Leontiev and E. I. Rasskazova, Questionnaire of Attributive Style STONE-B, the author's questionnaire aimed at collecting demographic and anamnestic data. The obtained data allow us to conclude that women with malignant neoplasms of the reproductive system, demonstrating posttraumatic growth, have higher rates of a sense of control (Uemp=89) and components of the optimistic attributive style of stability (Uemp=136.5), globality (Uemp=194.5) and optimism (Uemp=116) compared to women with malignant neoplasms of the reproductive system without posttraumatic growth. Interrelations between the components of posttraumatic growth, attributive style and the level of vitality were revealed.
Remoción de nutrientes de aguas residuales domésticas con Sagittaria latifolia y Sagittaria lancifolia en humedales artificiales de flujo libre
Authors: Estrada Pérez Nancy , López Ocaña Gaspar , Solís-Silván Rudy , Bautista-Margulis Raúl Germán , Torres Balcázar Carlos Alberto
Published: January 2025

Los humedales artificiales (HA) constituyen una solución viable para el tratamiento de aguas residuales desde una perspectiva económica, social y ambiental. La presente investigación evaluó la eficiencia de remoción del fósforo (PT), nitrógeno (NT) y demanda química de oxígeno (DQO) en aguas residuales domésticas utilizando las macrófitas acuáticas Sagittaria latifolia y Sagittaria lancifolia en humedales artificiales de flujo libre. El sistema de tratamiento incluye un tanque de distribución de aguas residuales domésticas y nueve humedales artificiales de flujo libre (HAFL): tres con S. latifolia, tres con S. lancifolia y tres sin vegetación (control). Los parámetros evaluados fueron la temperatura del agua cruda (26 ± 1.6 °C), HA con S. latifolia (26,24 ± 0,94 °C), HA con S. lancifolia (27,25 ± 0,47 °C) y el control (25,97 ± 0,82 °C); pH del agua cruda (7,8 ± 0,4 UpH), HA S. latifolia (7,72 ± 0,06 UpH), HA con S. lancifolia (7,53 ± 0,11 UpH) y el control (7,97 ± 0,22 UpH); fósforo total (PT) de agua cruda (14,37 ± 1,7 mg/L), HA S. latifolia (0,50 ± 0,22 mg/L), HA con S. lancifolia (0,89 ± 0,10 mg/L)  y el control (3,88 ± 0,63 mg/L);  nitrógeno total (NT) del agua cruda (82,94 ± 11,4 mg/L), HA S. latifolia (2,91 ± 1,3 mg/L), HA con S. lancifolia (5,4 ± 0,9 mg/L y el control (30,28 ± 2,5 mg/L). DQO del agua cruda (970,84 ± 115 mg/L), HA S. latifolia (29,55 ± 10,81 mg/L), HA con S. lancifolia (59,62 ± 5,88 mg/L) y el control (218,92 ± 35,43 mg/L). En los experimentos con S. latifolia, se lograron eficiencias de remoción del 97% para NT, 93% para PT y 96% para DQO, mientras para la S. lancifolia las eficiencias de remoción de NT, PT y DQO fueron de 97%, 94% y 93%.
Comparison of Classification Accuracy and Parameters of DINA, DINO, HO-DINA and HO-DINO Models in the Framework of Cognitive Diagnosis in Health Education
Authors: Gencan Sena , Tan Şeref
Published: January 2025

Purpose: This study aims to compare the parameters of DINA, DINO, HO-DINA and HO-DINO models according to different sample sizes (500, 2000, 5000) and different item numbers (60, 120) based on the Q matrices created for different attributes in health education based on simulation data.
Design/Methodology/Approach: In the simulation data, 50 replications were performed for each condition. In the study, two different Q-Matrixes were determined based on the learning domain determined by considering the 2018 TUS Spring Assessment Report and the taxonomy included in the Clinical assessment framework determined in Miller's 1990 study as the attributes dimension in the Q-Matrix in which matching of attribute and item is carried out. In the study, RMSEA, g and s parameters and classification accuracies were compared and under which conditions DINA, DINO, HO-DINA and HO-DINO models gave similar or different results were investigated.
Findings: According to the research findings, the Q-Matrix, in which Fields levels were used as the attribute dimension, was the matrix that gave the best parameter results in all models. In addition, it has been determined that the models that give the best RMSEA, g and s parameters and classification accuracies are DINO and HO-DINO models in the analysis.
Highlights: Based on the findings, when analyzing the results for the Basic Medical Sciences and Clinical Medical Sciences tests, it is evident that the Q matrix determined by Fields provides a better fit to the data, and moreover, it is advantageous for the Q matrix determined by Fields to be used for the TUS exam.
An Investigation of the Psychological Need Satisfaction Levels of Foster Families
Authors: Kıray Vural Bilgin , Körükçü Özlem , Taşdemir Gülay
Published: January 2025

Purpose: This study aimed to investigate the psychological need satisfaction levels of foster families.
Design/Methodology/Approach: The present study is descriptive and cross-sectional. Data were collected between July 1 and 30, 2020, from 138 volunteer foster parents living in Turkey.
Findings: The Need Satisfaction Scale was a significant difference was found by age group in the subscale and overall scale scores of the individuals participating in the study. Significant differences by families’ educational status were only present in the Competence subscale. Significant differences by age at which they became foster families were found in the Autonomy subscale and overall scores, and significant differences by age of fostered child were found in the Competence and overall scores (p
A Study on the Relationship Between School Principles' Technology Leadership and Life-long Learning Competencies
Authors: Gurkan Hilal , Alpaydın Yusuf , Tanoba Taner
Published: January 2025

Purpose: The aim of this study is to examine the relationships between technology leadership competencies and lifelong learning competencies of school principals and to reveal whether technology leadership and life-long learning competencies predict each other.
Design/Methodology/Approach: The research was designed according to the correlational survey method, as one of the quantitative research methods. The sample of the study is from 150 school principals of primary, middle, and high schools, that are public and private schools affiliated to Beykoz, Kadıköy, Üsküdar District Directorate of National Education in the 2017-2018 academic year. The data of the research were collected with the Technology Leadership Competence Scale, the Life-long Learning Competence Scale and the Personal Information Form. The data were analyzed by correlation and regression analyses.
Findings: As a result of the research; we found that technology leadership and life-long learning competency levels affect each other. Among the sub-dimensions of technology leadership, we found that only the dimension of excellence in professional development significantly predicted life-long learning competence. It is seen that life-long learning competence affects the level of technology leadership. However, it was found that none of the life-long learning competency dimensions significantly predicted technology leadership competency.
Highlights: In today's rapidly changing conditions, technology leadership is considered to be important. In this respect, the fact that life-long learning competence and technology leadership competence predict each other leads to the conclusion that steps should be taken to increase the competencies of administrators in this field in order to integrate the rapid changes brought by the digital age into education and training.
Examining Cyberbullying and Digital Citizenship of High School Students
Authors: Alakuş Hacer , Göksu İdris
Published: January 2025

Purpose: This research aimed to determine the relationship between cyberbullying and digital citizenship of high school students. It also aims to reveal how cyberbullying and digital citizenship scores differ according to various sociodemographic variables and technology use.
Design/Methodology/Approach: The correlational survey model was used. The data for this study was collected in 2022 from 204 high school students (male = 103, female = 101) aged 13-18 from six schools in XXX city. The Cronbach Alpha reliability coefficient was calculated as .94 for cyberbullying and .79 for digital citizenship. Data were analyzed using correlation analysis, t-test, and one-way ANOVA.
Findings: According to the results, it was determined that there was no statistically significant relationship between students' cyberbullying and digital citizenship. Additionally, students' cyberbullying scores do not differ according to gender. However, it was revealed that female students' digital citizenship scores were statistically significantly higher than males. It has been determined that the cyberbullying level of students with higher family income levels is also higher, and digital citizenship does not differ according to income level. In addition, it was found that the digital citizenship scores of high school students who use phones are significantly higher than those who do not. The cyberbullying scores of those who use Facebook are significantly lower than those who do not use Facebook. The digital citizenship scores of students who use Twitter, Facebook, and Instagram are significantly lower than those who do not. Finally, WhatsApp users' digital citizenship scores were significantly higher than those who did not use WhatsApp.
Highlights: There is no statistically significant relationship between digital citizenship and cyberbullying. Additionally, cyberbullying does not differ by gender. However, female students' digital citizenship scores were higher than males. Cyberbullying scores of students with high family income were higher than those with low family income. The cyberbullying score of students who use Facebook is higher than those who do not. Finally, it was determined that the digital citizenship scores of those who use Facebook, Twitter, and Instagram are lower than those who do not.
The Relationship Between Metacognition and AcademicAchievement in Adolescents: The Mediating Role of Academic Self-Control
Authors: Şimşir Gökalp Zeynep , Demirci Ayşe , Turgut İlkay
Published: January 2025

Purpose: The purpose of this study was to investigate the correlations between metacognition, academic self-control (ASC), and academic achievement among adolescents who attend secondary and high school and to test the mediating role of ASC in the correlation between metacognition and academic achievement.
Design/Methodology/Approach: The investigation was carried out using a correlational research approach. The sample group consisted of 572 adolescents (M = 14, SD = 1.28), who were aged between 11 and 17 years and studying in secondary and high schools in two cities in Türkiye. Demographic Questionnaire, Academic Self-Control Scale, and Metacognitive Awareness Inventory for Children were used in the study. The Jamovi V 2.2 software was utilized to analyze the data.
Findings: The Pearson correlation analysis showed that metacognition was positively associated with ASC and grade point average (GPA). Academic self-control was also positively correlated with GPA, as well. Moreover, the results of the current research demonstrated that the direct and indirect effects of metacognition on academic achievement were significant, and ASC played a partial mediating role in this correlation.
Highlights: The study's findings were discussed within the frame of the related literature, implications for theory were drawn, and suggestions for future studies were offered.
How to be a good science teacher? Teacher practices in the perspective of seven principles for good practice
Authors: Okumuş Seda
Published: January 2025

Purpose: The study aims to determine the practices and suggestions of science teachers toward seven principles for good practice.
Design: The research used a case study design. 73 science teachers (43 women and 30 men) working in different areas of Türkiye participated in this research. The researcher developed an open-ended questionnaire (Questionnaire of Seven Principles-QSP) to collect data. The frequency and percentage values of the answers were examined, and content analysis was made.
Findings: When evaluated according to gender, school type, experience, and region variables, science teachers had low knowledge about the seven principles. However, they practiced different practices related to each principle in and out of the classroom. In addition, as their experience increased, they had more social activities, valued communication with the family, and practiced more in the classroom.
Highlights: This study aims to determine what practices science teachers use to provide good practice and what suggestions they have. The results are important for improving the quality of science education.
Geografía del empleo y distribución intraurbana de la población en ciudades mexicanas: ¿ciudades monocéntricas o policéntricas?
Authors: Sobrino Jaime
Published: January 2025

En este artículo se estudia la distribución intraurbana de la población y de la demanda ocupacional en ciudades mexicanas. El propósito consiste en identificar y delimitar al área central de la ciudad y a los posibles subcentros, o nodos alternativos de concentración de empleo, a través de herramientas del análisis espacial. Los resultados muestran que los centros son áreas de gran jerarquía en la conformación de las ciudades mexicanas y que algunas, en especial las de más de medio millón de habitantes, han desarrollado subcentros y con ello una estructura bifuncional o policéntrica. Sin embargo, la organización intraurbana de la población se ajusta más a un modelo monocéntrico que a uno policéntrico.
Exploration-Exploitation Tradeoffs in Metaheuristics: A Review
Authors: Al-Himyari Bayadir Abbas , Al-khafaji Hiba , Hussain Noor Fadel
Published: January 2025

A metaheuristic algorithm is an algorithmic framework at a high level, independent of problems, which offers a set of recommendations or strategies to develop heuristic optimization algorithms. Evolutionary computation and other metaheuristics have long been focused on the trade-off between exploration and exploitation. This subject is present in a wide range of domains, including modeling and prediction, search and optimization, machine learning and cognition, and many more situations where uncertainty is present. The trade-off between exploration and exploitation is crucial for all optimization techniques. Efficient optimization and lower computing costs can be achieved by striking a fair balance between both.
The paper introduces a study that discusses metaheuristic algorithms and previous studies in three areas: 1) What elements of metaheuristic facilitate exploration and exploitation; 2) When and how exploration control is applied. 3) how to find a balance between the two.
Exploring the Usage of the Learning Management System in Oral Health Courses
Authors: Khareedi Rohini , Fernandez Daniel
Published: January 2025

Learning Management Systems (LMS) are being increasingly used in Higher Education to augment teaching and learning in both online and face-to-face courses. The oral health courses have adopted the same approach. This study explores the usage of the LMS by students in the oral health courses. The LMS usage data in each of the oral health courses were extracted through the learning analytics feature and analysed. The Year I students spent more time on the LMS than Year II students but less than the Year III students. Students spent more time on the LMS in clinical courses compared to nonclinical courses. A greater number of academic literary resources were accessed and downloaded through the LMS in nonclinical courses compared to clinical courses. Year III students least accessed the academic literary resources. The findings of the study, though not conclusive, have highlighted the potential implication of determinants like diversity of resources and assessment design on the usage of LMS.
La ciencia abierta y la evaluación de la producción científica
Authors: Piro María Cristina , Cottone Soledad , De Giusti Marisa R.
Published: January 2025

Este manuscrito contiene la transcripción del intercambio entre María Cristina Piro, Soledad Cottone y Marisa De Giusti sobre la ciencia abierta y la evaluación de la producción científica, que tuvo lugar durante la última sesión del evento Psicología (con)Ciencia Abierta.
Moderador: Nicolás Alessandroni
„Ja” w tekście, mieście i w historii. „Dziennik 1939–1942” Reni Spiegel
Authors: Pekaniec Anna
Published: January 2025

The diary written between 1939 and 1942 by Renia Spiegel, who lived with her grandparents in Przemyśl, is one of the unique Holocaust documents. Its author recorded her wartime daily life in the town on the San River in highly emotional, engaged, earnestly reliable notes. This text examines Spiegel's diaristic strategy, treating the notes as an idiosyncratic dialogue (or sometimes polylogue), in which confession, prayer and lyrical fragments are combined. The diary subject of the teenage girl is not just a product of textual creation; in fact, it becomes a figure gaining special protection from the world through narrative mediation. Living in a city occupied by the Russians and the Germans, Spiegel often pushes aside the painful historical experience by writing – focusing on everyday life, her relationships with family and friends, love, and plans for the future. This diary of an adolescent girl was like a veil, separating her from the Holocaust.
Więcej-niż-ludzka-społeczność. Literackie obrazowanie czarnobylskiej natury w perspektywie heterotopii afektywnej
Authors: Feliksik Paulina
Published: January 2025

This article examines the literary visualizations of the Chernobyl wildness within the theoretical framework which combines the concept of affective heterotopia, formulated by Aleksandra Wójtowicz, the approach of environmental humanities and a notion of community encompassing the social lives of non-human beings (along the lines of Anna Tshing’s ‘more-than-human-sociality’). A survey of some Chernobyl-related texts, including Svetlana Alexievich’s Chernobyl Prayer, is intended to demonstrate the usefulness of the proposed methodology in analyzing the whole range of affective heterotopias. As each of them is grounded in its peculiar historical and social contexts, their subsequent readings need to take full account of their location in time and space.
Determinants of E-Learning Adoption: Evidence from the Telecommunications Industry in Vietnam
Authors: BUI Tuyen Quang , NGUYEN Ngoc Minh , NGUYEN Phuong Mai
Published: January 2025

As a response to the global digital transformation trend, e-learning has been chosen as a critical method in corporate training worldwide due to its efficiency and flexibility. However, the adoption of an e-learning system is limited in developing countries, particularly in enterprises. In such a context, this research examines factors affecting e-learning adoption in the Vietnamese telecommunications industry. A research model was developed based on the technology acceptance model (TAM), adding three antecedents: management support, technical support, and course quality. Using data collected from 248 employees working in the industry, we ran a structural equation modeling analysis to test seven proposed hypotheses. Our findings showed that perceived usefulness and perceived ease of use mediate the impact of management support, technical support, and course quality on e-learning adoption. Based on our findings, we proposed several suggestions to improve the e-learning system and promote the adoption of elearning in Vietnamese companies.
An easy analytical method for the determination of L-Canavanine in legumes and pulse-based fish feed
Authors: Anagnostopoulos C. , Charalampous A.C. , Liapis K.
Published: January 2025

L-Canavanine is a naturally occurring non-protein amino acid found in certain legumes, where it plays a significant role in plant defence acting as an anti-herbivory compound by disrupting the biology of insect herbivores and pulse-based fish feed. In this study, a simple, easy and robust analytical method was developed and validated to monitor the compound accurately and reliable. The developed method includes a simple quick and low-cost extraction procedure using acidified acetonitrile. Chromatographic determination is based on Hydrophilic Interaction Liquid Chromatography coupled to tandem mass spectrometry operating in positive electron spray ionization. The method was successfully validated by assessing accuracy, precision, linearity of response (gradient of the calibration curve) at a range of concentrations 1.25 - 25 μg L−1, matrix effect and limit of quantitation according to European Guidelines. One way analysis of variance (ANOVA) was employed for estimating the contribution to overall uncertainty and finally to the reported value/concentration, of homogenization and sub-sampling step.
INSIGHTS ON THE PROTON TRANSLOCATION PATHWAYS IN BACTERIAL FOF1 -ATP SYNTHASE
Authors:   Institute of Cytochemistry and Molecular Pharmacology, Moscow, Ivontsin L.A. ,   Pirogov Russian National Research Medical University, Moscow,   Biomedical Research Group, BiDiPharma GmbH, Siek, Germany, Mashkovtseva E.V. , Nartsissov Y.R.
Published: January 2025

Molecular dynamics simulations were used to study the structure of proton half-channels of Fo
F1
-ATP synthase. A proton transfer chain consisting of conserved amino acid residues and water molecules clusters was identified. The effect of cardiolipins on protein
hydration was evaluated. Mutational analysis was conducted to investigate the role of functional elements of the protein structure in the
process of proton transport.
One million (paper) satellites
Authors: Wright Ewan , Falle Andrew
Published: January 2025

Plans for over one million satellites have been submitted to the International Telecommunications Union, a United Nations agency, in the last 6 years. Either many of these satellites will launch, and cause environmental problems on Earth and in orbit, or companies and governments are inflating their numbers, suggesting more satellites than they plan to launch.
Chik sign
Authors: Meghana Ponugoti , Meda Susmitha , Ravi S.S , Behara Suresh Kumar
Published: January 2025

Objectives

The objective is to study the cutaneous manifestations in suspected cases of Chikungunya fever.

Material and Methods

A study was carried out in the outpatient department of DVL at Government General Hospital in Kakinada, India from July 2024 to September 2024. The study enrolled 24 patients with cutaneous manifestations, a history of fever, and arthralgia.

Results

Out of 24 patients, the Chik sign was found more often in males than in females. The patients showed hyper-pigmentation of the centro-facial region.

Conclusion

The Chik sign is seen in chikungunya fever and other arboviral diseases such as dengue. All patients had negative results on dengue serology. This series of Chik signs plays a significant role in diagnosing patients with Chikungunya in areas with limited resources.
A rare confluence: Intratumoral arteriovenous malformation in renal cell carcinoma
Authors: Mudaliar Ramya , Mangalagiri Nikhitha , Dhruv R.P. , Banothu Preethi
Published: January 2025

Renal cell carcinoma (RCC) is the most common renal tumor, accounting for approximately 2% of adult malignancies. However, there are also rare presentations of RCC with metastatic sites, paraneoplastic disease, and abnormal findings that may mislead to diagnosis, including bleeding or vascular malformation like arteriovenous malformation (AVM). Here we present the case of a woman complaining of hematuria, weakness, and fatigue. Ultrasound examination revealed a large mixed echogenic lesion in the right kidney, and further examination revealed a large renal lesion with intratumoral AVM.
The last resort that saved two lives: Emergency obstetric hysterectomy
Authors: Nair Priya Pratapan
Published: January 2025

The case report aims to guide through the management of postpartum hemorrhage and timely intervention to save a mother’s life. In a developing country, even though the statistics have improved, postpartum hemorrhage (PPH) still accounts for the commonest cause of maternal mortality. Its prevalence is about four cases in 10,000 deliveries. Even though several advances are made in the medical and surgical field to preserve a uterus, like oxytocin, methergine, prostaglandins, newer drugs like carbetocin and surgical methods like balloon tamponade, condom catheter, systemic devascularization, internal iliac artery ligation, B lynch sutures, cho sutures, sometimes all the resorts fail and the female lands up in emergency obstetric hysterectomy (OH) for saving her life. We present a case of a low-risk parous woman who was induced for the normal trial of labor and her journey through labor, emergency lower segment cesarean section, and then OH as a lifesaving procedure. Timely decisions and prompt action are needed during the golden hour of PPH to save a mother and child. Clinical significance is that obstetrics hysterectomy is associated with morbidity and is a last resort that can be used to save a patient’s life when all the other medical and surgical management fail to avoid morbidity and mortality.
An isthmic ectopic pregnancy - Atypical presentation
Authors: Nair Priya Pratapan
Published: January 2025

The most dreadful gynecological crisis, ectopic pregnancy (EP), affects 2% of pregnancies. Almost 85% to 95% of ectopic pregnancy implants in the ampulla of the fallopian tube, the next most common area of implantation is in the isthmus (12%). In the isthmic pregnancy, the tubal wall is damaged beyond repair. There are multiple factors responsible for tubal ectopic pregnancy; a combination of structural tubal anomalies and tubal dysfunction has been mainly postulated. Isthmic ectopic pregnancy commonly ruptures into the broad ligament due to the position of the tube near the fundus, and an ampullary pregnancy ruptures in the abdominal cavity. Nowadays, systemic methotrexate can be used as a conservative medical method to treat many ectopic pregnancies. Here, we present a case of a multigravida with 5 weeks amenorrhea with an atypical presentation of isthmic tubal unruptured ectopic pregnancy, which was initially diagnosed as being an ovarian ectopic pregnancy, but the timely intervention helped save the life of a patient with minimum morbidity.
A Case of Herpes Simplex Oesophagitis
Authors: Gattani Nikunj Atul , Dhande Siddharth , Pande Vivek
Published: January 2025

Herpes simplex virus (HSV) oesophagitis results from direct extension of oral pharyngeal infection into the oesophagus or occurs de novo by reactivation and spread of HSV to the oesophageal mucosa through the vagus nerve. The predominant symptoms are odynophagia, dysphagia, substernal pain and weight loss. Multiple ulcerations appear on an erythematous base with or without a white pseudomembrane. The distal oesophagus is most commonly involved. Endoscopically obtained secretions for cytologic examination and culture or deoxyribonucleic acid detection by polymerase chain reaction provide the most useful material for diagnosis. Upper gastrointestinal endoscopy biopsy was diagnostic in this case.
Severe Mitral Regurgitation: A Rare Manifestation of Chemotherapy-Induced Cardiotoxicity
Authors: Jawahirani Anil Ramesh , Kalamkar R B , Washimkar S N , Chougule Aishwarya
Published: January 2025

Chemotherapy has many side effects, and one which has deadly effects is cardiotoxicity. It can present as hypertension, myocardial ischaemia, arrhythmia, heart failure and thromboembolism. However, we hereby report a case of severe mitral regurgitation as a rare complication of chemotherapy.
Advancements in Extracorporeal Therapies for Managing Sepsis: A Comprehensive Review
Authors: Doifode Prafulla Karbhari , Ramteke Vishal , Dambhare Nitin
Published: January 2025

Sepsis remains a critical condition associated with high morbidity and mortality rates despite advances in medical care. The dysregulated host response to infection leads to systemic inflammation and multi-organ dysfunction, often exacerbated by a cytokine storm involving both proinflammatory and anti-inflammatory mediators. Extracorporeal therapies have emerged as potential adjuncts in sepsis management, aiming to mitigate the inflammatory response and support vital organ function. These therapies include various modalities such as adsorption of inflammatory mediators, removal of endotoxins and cytokine clearance using specialised filters and devices. This review explores the principles, mechanisms and clinical evidence surrounding extracorporeal therapies in sepsis, highlighting their potential benefits and current limitations. Key devices discussed include polymyxin B haemoperfusion, CytoSorb haemoadsorption, high-volume hemofiltration and novel technologies such as the oXiris membrane and Seraph-100 Microbind Affinity Blood Filter. Clinical trials and studies assessing these therapies provide insights into their efficacy in improving haemodynamics, organ function and mortality outcomes in septic patients. Despite promising results in certain trials, variability in patient responses and conflicting evidence necessitate further research to refine treatment protocols and optimise patient selection criteria for extracorporeal therapies in sepsis.
أثر قواعد الحوكمة المؤسسية على الافصاح وجودة التقارير المالية: دراسة ميدانية على الشركات المدرجة بالسوق المالي السعودي
Authors: البلوي حنان راشد
Published: January 2025

تناولت هذه الدراسة أثر قواعد الحوكمة المؤسسية على الإفصاح وجودة التقارير المالية من خلال دراسة ميدانية شملت الشركات المدرجة في السوق المالي السعودي. استخدم الباحث المنهج الوصفي التحليلي، وجمع البيانات عبر استبانة وزعت على 90 عضوًا من مجلس الإدارة والمديرين التنفيذيين للشركات المدرجة في السوق المالي السعودي لسنة 2024. تم تحليل البيانات باستخدام برنامج التحليل الإحصائي (SPSS) لاختبار الفرضيات والوصول إلى نتائج موثوقة. أظهرت نتائج الدراسة أن تطبيق قواعد الحوكمة ساهم بشكل ملحوظ في تعزيز مستوى الإفصاح، وأدى إلى تحسين جودة التقارير المالية للشركات. كما تبيّن أن تطوير ثقافة الحوكمة انعكس إيجابيًا على استمرارية الشركات وتعزيز موقعها في السوق المالي، مما يدعم تحقيق أهدافها على المدى البعيد. أكدت الدراسة أهمية وجود هيكل تنظيمي وإداري يتسم بالمهنية والمصداقية لضمان التنفيذ الفعّال لمبادئ الحوكمة. أوصت الدراسة بضرورة تعزيز المفاهيم والالتزام بالقواعد التي وضعتها منظمة التعاون الاقتصادي والتنمية من خلال تقديم دورات تدريبية وتأهيلية، مع التأكيد على ضرورة إنشاء لجنة متخصصة لمتابعة تطبيق مبادئ وقواعد الحوكمة وضمان التزام الشركات بها. كما دعت إلى نشر ثقافة الحوكمة بشكل أوسع بين جميع الأطراف المعنية، مع توفير النشرات والتعليمات التي تدعم هذا التوجه، بما يسهم في تعزيز مبادئ الحوكمة في المجتمع المالي وتحسين جودة الإفصاح للشركات المدرجة في السوق المالي السعودي.
أثر التدريب والتطوير المهني على تعزيز الكفاءة وتطوير واستدامة الشركات العائلية في المملكة العربية السعودية
Authors: نذير حنان عبدالله
Published: January 2025

إن الشركات العائلية لها دورها الكبير والفاعل في الاقتصاد بشكل عام سواء في الدول المتقدمة أو النامية، لأنها هي الممثلة لأكبر جزء من المشاريع الصغيرة والمتوسطة، وفي ظل هذا التطور العام بدأ ظهور أهمية التدريب والتطوير المهني كواحد من العناصر الأساسية لتحقيق سبل الاستدامة لهذه الشركات والتعزيز لكفائتها بالمملكة، هذا لان التدريب هو أداة استراتيجية تساهم في تحسين الأداء التنظيمي للشركة ككل، لهذا سعى هذا البحث للعمل على الوصول لأثر التدريب والتطوير المهني على تعزيز الكفاءة وتطوير واستدامة الشركات العائلية في المملكة العربية السعودية، وذلك من خلال طرح سؤال والعمل على الوصول لإجابة له، وهذا السؤال هو: ما تأثير برامج التدريب والتطوير المهني على كفاءة الموظفين في الشركات العائلية في المملكة العربية السعودية؟ وكيف يسهم التدريب والتطوير المهني في تطوير أداء الشركات العائلية وتحقيق أهدافها الاستراتيجية؟، حيث استخدم البحث المنهج الوصفي التحليلي للوصول للإجابة عن هذه الأسئلة، وقد توصل البحث لنتائج منها: عدم وجود فروق معنوية دالة احصائية عند مستوى معنوية  0.05 في جميع متوسطات أبعاد استبانة أثر التدريب والتطوير المهني على تعزيز الكفاءة وتطوير واستدامة الشركات العائلية في المملكة العربية السعودية بمعنى أن سنوات الخبرة لا تؤثر على الآراء حول أثر التدريب والتطوير المهني على تعزيز الكفاءة وتطوير واستدامة الشركات العائلية في المملكة العربية السعودية، بينما توجد علاقة ارتباط طردية قوية ذات دلالة إحصائية بين التدريب والتطوير المهني واستدامة الشركات العائلية عند مستوى معنوية 0.01 ويتبين وجود أثر طردي ذو دلالة إحصائية للتدريب والتطوير المهني على استدامة الشركات العائلية عند مستوى معنوية 0.01.
Benchmarking of Density Functional Theories for Combustion Reactions in Alkanes by Evaluating Thermodynamic Properties
Authors: Fatema Kaniz
Published: January 2025

Computational calculations are playing vital role in this era of artificial intelligence and machine learning which is capable to lessen the burden of experimental expenses. Inevitably, to benchmark different theoretical methods is essential to produce accurate results while keeping in mind the computational cost. In this study, different functionals of Density Functional Theory (DFT) with 2 different basis sets were benchmarked to compute thermodynamic properties, enthalpy, Gibbs free energy, and entropy, of alkane combustion reactions. Results indicate a linear relationship between the number of carbon atoms and reaction parameters, with deviations arising from method-dependent approximations. LSDA and dispersion-corrected methods demonstrated closer agreement with experimental values with correlation-consistent basis set, while higher-rung functionals like PBE and TPSS exhibited significant errors with split-valence basis set, especially for larger chain lengths. Notably, convergence issues were observed for n-hexane with PBE and TPSS, attributed to near-degenerate states and SCF instability. These findings highlight the importance of functional choice along with the basis set to define the orbitals to accurately predict thermodynamic properties.
Nickel-Catalyzed [4 + 4] Cycloaddition of Diene-Vinylcyclobutanones
Authors: Li Bing-Wen , Duan Jicheng , Ma Jiguo , Yu Zhi-Xiang
Published: January 2025

Reported here is a Ni(0)-catalyzed [4 + 4] cycloaddition of diene-vinylcyclobutanones to access trans-5/8 bicyclic structure with a bridgehead quaternary carbon center, which is found in natural products but cannot be accessed by existing transition metal cata-lyzed cycloadditions. This [4+4] reaction has broad scope and the catalyst used is the earth-abundant Ni complex. Key to the suc-cess of the [4+4] cycloaddition is utilizing the vinyl group in the substrates to activate the cyclobutanone (substrate with an alkyl group failed to realize the [4+4] reaction). Of the same importance, the vinyl group in the final [4+4] cycloadducts can be trans-formed into other functional groups so that 5/8 products with various substituents at bridgehead position can be pursued. DFT calcu-lations have been applied to reveal how the vinyl-group assisted C-C cleavage, diene insertion (via an unexpected endo-metal-insertion mode), ligand dissociation, and reductive elimination take place consecutively. Among them, the ligand dissociation pro-cess, benefiting from a higher reaction temperature (80 °C), is critical to favor the [4+4] reaction and suppress the competing vinyl-cyclobutanone rearrangement and Diels-Alder reaction.
To what extent can we extrapolate Proteochemometric models: A case study for the SLC6 transporter family
Authors: Abu Shehab Uday , Ecker Gerhard
Published: January 2025

Proteochemometrics modeling (PCM) combines protein and ligand information to create predictive models for biological activity. It has great potential to extrapolate information across targets, enabling its application in screening drug candidates across a whole family of proteins. In this study, we present a series of PCM models for the SLC6 transporter family showing reasonable performance (Q2 values up to 0.79) when using standard validation metrics. Moreover, feature importance analysis pointed towards residue position A173 in hSERT, corresponding to G149 and G153 in hNET and hDAT, respectively, to be relevant for subtype selectivity. However, examining the impact of different data splits on model validation metrics highlights potential over-optimism when only considering target stratification splits. Furthermore, when performing leave-one-transporter-out studies, a considerable drop in performance was observed. This points towards the need for more complex technologies to exploit the potential of PCM and identify new drug candidates.
To what extent can we extrapolate Proteochemometric models: A case study for the SLC6 transporter family
Authors: Abu Shehab Uday , Ecker Gerhard F.
Published: January 2025

Proteochemometrics modeling (PCM) combines protein and ligand information to create predictive models for biological activity. It has great potential to extrapolate information across targets, enabling its application in screening drug candidates across a whole family of proteins. In this study, we present a series of PCM models for the SLC6 transporter family showing reasonable performance (Q2 values up to 0.79) when using standard validation metrics. Moreover, feature importance analysis pointed towards residue position A173 in hSERT, corresponding to G149 and G153 in hNET and hDAT, respectively, to be relevant for subtype selectivity. However, examining the impact of different data splits on model validation metrics highlights potential over-optimism when only considering target stratification splits. Furthermore, when performing leave-one-transporter-out studies, a considerable drop in performance was observed. This points towards the need for more complex technologies to exploit the potential of PCM and identify new drug candidates.
Toward Accurate Quantum Mechanical Thermochemistry: (2) Optimal Methods for Enthalpy Calculations from Comprehensive Benchmarks of 284 Model Chemistries
Authors: Wu Haoyang , Doner Anna C. , Pang Hao-Wei , Green William H.
Published: January 2025

Accurate and efficient computations of standard enthalpies of formation (Hf) for small organic molecules are crucial for diverse chemical engineering and scientific applications. Building upon our earlier work [J. Phys. Chem. A 2024, 128, 21, 4335–4352], we systematically benchmark 284 model chemistries for Hf computations. These methods span semiempirical approaches, density functional theory (DFT), wave function theory, and composite schemes. We derive Petersson- and Melius-type bond-additivity corrections (BACs) for each method using a curated database of 421 reference species. We further validate the top-performing methods using an independent test set of 500 species including ions, radicals, and other challenging cases. Across nearly all methods and species, BACs significantly improve accuracy, especially for neutral singlet species. Composite schemes coupling moderate-level DFT geometries with local coupled-cluster single-point energies strike an excellent balance between cost and accuracy, often approaching chemical accuracy ($\leq$ 1 kcal/mol). Notably, DLPNO-CCSD(T)-F12d/cc-pVTZ-F12//ωB97X-D/def2-TZVPD with Petersson BAC attains the benchmark-best mean absolute error (MAE) of 0.57 kcal/mol. Remarkably, switching to DLPNO-CCSD(T)-F12d/cc-pVDZ-F12//GFN2-xTB substantially reduces the computational cost by an order of magnitude while modestly increasing the MAE (0.96 kcal/mol). Although carefully tuned model chemistries can also benefit charged and open-shell species, the scarcity of robust reference data in these areas highlights the need for broader, high-accuracy thermochemistry datasets. Overall, this benchmark provides practical guidance on selecting optimal model chemistries to efficiently compute accurate Hf under varied computational constraints and molecular complexities, laying a foundation for large-scale, high-throughput thermochemical calculations that will support data-driven discovery and industrial applications.