bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Multi-Frequency Bioelectrical Impedance Analysis against Dual-Energy X-ray Absorptiometry for Estimation of Low Muscle Mass in Older Hospitalized Patients
Authors: Nielsen Rikke Lundsgaard , Andersen Aino Leegaard , Kallemose Thomas , Damgaard Morten , Bornæs Olivia , Juul-Larsen Helle Gybel , Strejby Christensen Louise Westberg , Jawad Baker Nawfal , Andersen Ove , Rasmussen Henrik Højgaard , Munk Tina , Lund Trine Meldgaard , Houlind Morten Baltzer
Published: December 2023

The accuracy of multi-frequency (MF) bioelectrical impedance analysis (BIA) to estimate low muscle mass in older hospitalized patients remains unclear. This study aimed to describe the ability of MF-BIA to identify low muscle mass as proposed by The Global Leadership Initiative on Malnutrition (GLIM) and The European Working Group on Sarcopenia in Older People (EWGSOP-2) and examine the association between muscle mass, dehydration, malnutrition, and poor appetite in older hospitalized patients. In this prospective exploratory cohort study, low muscle mass was estimated with MF-BIA against dual-energy X-ray absorptiometry (DXA) in 42 older hospitalized adults (≥65 years). The primary variable for muscle mass was appendicular skeletal muscle mass (ASM), and secondary variables were appendicular skeletal muscle mass index (ASMI) and fat-free mass index (FFMI). Cut-off values for low muscle mass were based on recommendations by GLIM and EWGSOP-2. MF-BIA was evaluated against DXA on the ability to estimate absolute values of muscle mass by mean bias, limits of agreement (LOA), and accuracy (5% and 10% levels). Agreement between MF-BIA and DXA to identify low muscle mass was evaluated with sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV). The association between muscle mass, dehydration, malnutrition, and poor appetite was visually examined with boxplots. MF-BIA overestimated absolute values of ASM with a mean bias of 0.63 kg (CI: −0.20:1.46, LOA: −4.61:5.87). Agreement between MF-BIA and DXA measures of ASM showed a sensitivity of 86%, specificity of 94%, PPV of 75% and NPV of 97%. Boxplots indicate that ASM is lower in patients with malnutrition. This was not observed in patients with poor appetite. We observed a tendency toward higher ASM in patients with dehydration. Estimation of absolute ASM values with MF-BIA should be interpreted with caution, but MF-BIA might identify low muscle mass in older hospitalized patients.
Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis
Authors: Ozturk Nazli Begum , Dinc Ece Janet , Swami Abhishek , Gurakar Ahmet
Published: December 2023

Acute kidney injury (AKI) is common in hospitalized patients with cirrhosis. Hepatorenal syndrome (HRS) is a type of AKI known as HRS-AKI. It is a severe complication of cirrhosis with high morbidity and mortality. While certain vasoconstrictor medications have been shown to improve HRS-AKI, no clear transplant-free survival benefit has been reported with medical therapies. Patients with HRS-AKI should be considered for urgent liver transplantation evaluation. In this review, we discuss the most recent updates on the definition, diagnosis, and management of AKI in cirrhosis, with special a emphasis on HRS.
The Role of Illness Perceptions in Dyspnoea-Related Fear in Chronic Obstructive Pulmonary Disease
Authors: Hill Kylie , Hug Sarah , Smith Anne , O’Sullivan Peter
Published: December 2023

Dyspnoea is often the most distressing symptom described by people with a chronic respiratory condition. The traditional biomedical model of neuromechanical uncoupling that explains the physiological basis for dyspnoea is well accepted. However, in people with chronic obstructive pulmonary disease (COPD), measures that are linked with neuromechanical uncoupling are poorly related to the restriction in activity during daily life attributed to dyspnoea. This suggests that activity restriction that results from dyspnoea is influenced by factors other than expiratory airflow limitation and dynamic pulmonary hyperinflation, such as the ways people perceive, interpret and respond to this sensation. This review introduces the common-sense model as a framework to understand the way an individual’s lay beliefs surrounding sensations can lead to these sensations being perceived as a health threat and how this impacts their emotional and behavioural responses. The aim is to provide insight into the nuances that can shape an individual’s personal construct of dyspnoea and offer practical suggestions to challenge unhelpful beliefs and facilitate cognitive re-structuring as a pathway to reduce distress and optimise health behaviours and outcomes.
Intrinsic Sinus Node/Atrioventricular Node Dysfunction Requiring Pacemaker Implantation: Role of Former Professional Sport Activity
Authors: Bondarev Sergei , Achkasov Evgeny , Zorzi Alessandro , Safaryan Alexandr , Graziano Francesca , Sizov Alexey
Published: December 2023

Background: Sinus bradycardia and first degree or second degree Mobitz type I atrioventricular (AV) block in an athlete are considered adaptive and reversible phenomena; however, some evidence suggests that they may persist after detraining and become pathological. The aim of the study was to investigate the characteristics of a group of former professional athletes who required pacemaker (PM) implantation for intrinsic (idiopathic) sinus node (SN) dysfunction or AV block in comparison to control groups of sedentary individuals. Methods: We included all patients who underwent PM implantation during 2022. Three groups were compared: group 1 including 18 former professional athletes who received a PM for SN dysfunction/AV block in the absence of heart disease; group 2 including the first 20 sedentary individuals without heart disease who underwent PM implantation; and group 3 including all other 323 patients who received PM, the majority with underlying heart diseases. Results: Compared to the non-athlete control group 2, the mean age at diagnosis and at the time of PM implantation of former professional athletes did not show statistically significant differences. However, subgroup analysis revealed significant differences depending on the type of sports discipline: the age at diagnosis and at PM implantation was significantly lower in former endurance athletes than former strength/mixed athletes, control non-athletes, and all other patients. Moreover, former endurance professional athletes exhibited a higher prevalence of second or third degree AV block (78%) as the reason for PM implantation compared to power/mixed athletes (44%). The other clinical characteristics, including echocardiographic parameters, did not differ between former athletes and non-athletes. Conclusions: Former professional endurance athletes with idiopathic SN dysfunction/AV block manifested the disease earlier in the life course compared to former power/mixed athletes and non-athletes. This suggests that bradycardia/AV block caused by intense and prolonged endurance sports may not always be benign and adaptive phenomena.
Differences between SCORE, Framingham Risk Score, and Estimated Pulse Wave Velocity-Based Vascular Age Calculation Methods Based on Data from the Three Generations Health Program in Hungary
Authors: Gyöngyösi Helga , Szőllősi Gergő József , Csenteri Orsolya , Jancsó Zoltán , Móczár Csaba , Torzsa Péter , Andréka Péter , Vajer Péter , Nemcsik János
Published: December 2023

Early vascular ageing contributes to cardiovascular (CV) morbidity and mortality. There are different possibilities to calculate vascular age including methods based on CV risk scores, but different methods might identify different subjects with early vascular ageing. We aimed to compare SCORE and Framingham Risk Score (FRS)-based vascular age calculation methods on subjects that were involved in a national screening program in Hungary. We also aimed to compare the distribution of subjects identified with early vascular ageing based on estimated pulse wave velocity (ePWV). The Three Generations for Health program focuses on the development of primary health care in Hungary. One of the key elements of the program is the identification of risk factors of CV diseases. Vascular ages based on the SCORE and FRS were calculated based on previous publications and were compared with chronological age and with each other in the total population and in patients with hypertension or diabetes. ePWV was calculated based on a method published previously. Supernormal, normal, and early vascular ageing were defined as <10%, 10–90%, and >90% ePWV values for the participants. In total, 99,231 subjects were involved in the study, and among them, 49,191 patients had hypertension (HT) and 15,921 patients had diabetes (DM). The chronological age of the total population was 54.0 (48.0–60.0) years, while the SCORE and FRS vascular ages were 59.0 (51.0–66.0) and 64.0 (51–80) years, respectively. In the HT patients, the chronological, SCORE, and FRS vascular ages were 57.0 (51.0–62.0), 63.0 (56.0–68.0), and 79.0 (64.0–80.0) years, respectively. In the DM patients, the chronological, SCORE, and FRS vascular ages were 58.0 (52.0–62.0), 63.0 (56.0–68.0), and 80.0 (76.0–80.0) years, respectively. Based on ePWV, the FRS identified patients with an elevated vascular age with high sensitivity (97.3%), while in the case of the SCORE, the sensitivity was much lower (13.3%). In conclusion, different vascular age calculation methods can provide different vascular age results in a population-based cohort. The importance of this finding for the implementation in CV preventive strategies requires further studies.
Safety and Feasibility of Intraoperative High PEEP Titrated to the Lowest Driving Pressure (ΔP)—Interim Analysis of DESIGNATION
Authors: Nijbroek Sunny G. L. H. , Hol Liselotte , Serpa Neto Ary , van Meenen David M. P. , Hemmes Sabrine N. T. , Hollmann Markus W. , Schultz Marcus J.
Published: December 2023

Uncertainty remains about the best level of intraoperative positive end–expiratory pressure (PEEP). An ongoing RCT (‘DESIGNATION’) compares an ‘individualized high PEEP’ strategy (‘iPEEP’)—titrated to the lowest driving pressure (ΔP) with recruitment maneuvers (RM), with a ‘standard low PEEP’ strategy (‘low PEEP’)—using 5 cm H2O without RMs with respect to the incidence of postoperative pulmonary complications. This report is an interim analysis of safety and feasibility. From September 2018 to July 2022, we enrolled 743 patients. Data of 698 patients were available for this analysis. Hypotension occurred more often in ‘iPEEP’ vs. ‘low PEEP’ (54.7 vs. 44.1%; RR, 1.24 (95% CI 1.07 to 1.44); p < 0.01). Investigators were compliant with the study protocol 285/344 patients (82.8%) in ‘iPEEP’, and 345/354 patients (97.5%) in ‘low PEEP’ (p < 0.01). Most frequent protocol violation was missing the final RM at the end of anesthesia before extubation; PEEP titration was performed in 99.4 vs. 0%; PEEP was set correctly in 89.8 vs. 98.9%. Compared to ‘low PEEP’, the ‘iPEEP’ group was ventilated with higher PEEP (10.0 (8.0–12.0) vs. 5.0 (5.0–5.0) cm H2O; p < 0.01). Thus, in patients undergoing general anesthesia for open abdominal surgery, an individualized high PEEP ventilation strategy is associated with hypotension. The protocol is feasible and results in clear contrast in PEEP. DESIGNATION is expected to finish in late 2023.
The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine
Authors: Musuroi Silvia Ioana , Voinescu Adela , Musuroi Corina , Baditoiu Luminita Mirela , Muntean Delia , Izmendi Oana , Jumanca Romanita , Licker Monica
Published: December 2023

The emergency department (ED) represents an important setting for addressing inappropriate antimicrobial prescribing practices because of the time constraints and the duration of microbiological diagnosis. The purpose of this study is to evaluate the etiology and antimicrobial resistance (AMR) pattern of the community-acquired pathogens, as well as the epidemiological characteristics of patients admitted through the ED, in order to guide appropriate antibiotic therapy. Methods: A retrospective observational study was performed on 657 patients, from whom clinical samples (urine, purulent secretions, blood cultures, etc.) were collected for microbiological diagnosis in the first 3 days after presentation in the ED. The identification of pathogens and the antimicrobial susceptibility testing with minimum inhibitory concentration determination were carried out according to the laboratory protocols. Results: From the 767 biological samples analyzed, 903 microbial isolates were identified. E. coli was most frequently isolated (24.25%), followed by Klebsiella spp., S. aureus (SA), and non-fermentative Gram-negative bacilli. E. coli strains maintained their natural susceptibility to most antibiotics tested. In the case of Pseudomonas spp. and Acinetobacter spp., increased rates of AMR were identified. Also, 32.3% of SA strains were community-acquired MRSA. Conclusions: The introduction of rapid microbiological diagnostic methods in emergency medicine is imperative in order to timely identify AMR strains and improve therapeutic protocols.
Multifunctional Plants: Ecosystem Services and Undervalued Knowledge of Biocultural Diversity in Rural Communities—Local Initiatives for Agroecological Transition in Chile
Authors: Peredo Parada Santiago , Barrera Salas Claudia
Published: December 2023

With the aim of contributing to the understanding of plants’ multifunctionality for sustainable agroecosystem management, the first part of this paper addresses the importance of functional biodiversity in the design of agroecological systems, including the local context in the generation of situated knowledge. The second part describes three participatory research experiences with local farmers across three locations in Chile. The first experience reports on the use of Dasyphyllum diacanthoides (endemic tree) as fodder. A second experience focuses on the establishment of Rosa spp. (invasive species) as an agroforestry system integrated into the landscape. Both experiences were collaborative efforts with farmer communities of the Andean Mountains in southern Chile. The final experience describes the use of different spontaneous aromatic and medicinal plants through biological corridors to encourage beneficial insects as natural controllers. All three research experiences reveal a lack of knowledge, decontextualization, and undervaluation of the biocultural diversity present in some traditional Chilean agroecosystems.
HER2 Alterations in Non-Small Cell Lung Cancer: Biologico-Clinical Consequences and Interest in Therapeutic Strategies
Authors: Loeffler Emma , Ancel Julien , Dalstein Véronique , Deslée Gaëtan , Polette Myriam , Nawrocki-Raby Béatrice
Published: December 2023

Lung cancer stands as the first cause of death by cancer in the world. Despite the improvement in patients’ outcomes in the past decades through the development of personalized medicine approaches, a substantial portion of patients remains ineligible for targeted therapies due to the lack of a “druggable” molecular target. HER2, a receptor tyrosine kinase member of the EGFR/ErbB family, is known to show oncogenic properties. In this review, we focus on the different HER2 dysregulation mechanisms that have been observed in non-small cell lung cancer (NSCLC): gene mutation, gene amplification, protein overexpression and protein hyper-phosphorylation, the latter suggesting that HER2 dysregulation can occur independently of any molecular aberration. These HER2 alterations inevitably have consequences on tumor biology. Here, we discuss how they are not only involved in abnormal proliferation and survival of cancer cells but also potentially in increased angiogenic properties, mesenchymal features and tumor immune escape. Finally, we review the impact of these HER2 alterations in various therapeutic approaches. While standard chemotherapy and groundbreaking immunotherapy seem rather ineffective for HER2-altered NSCLCs, the development of HER2-targeted therapies such as tyrosine kinase inhibitors, anti-HER2 antibodies and especially antibody–drug conjugates could provide new hopes for patients.
Hemoadsorption in Organ Preservation and Transplantation: A Narrative Review
Authors: García-Villegas Refugio , Arni Stephan
Published: December 2023

Cytokine adsorption can resolve different complications characteristic of transplantation medicine, such as cytokine storm activation and blood ABO and immune incompatibilities. Cytokine adsorption is also performed for the treatment of various life-threatening conditions, such as endotoxic septic shock, acute respiratory distress syndrome, and cardiogenic shock, all potentially leading to adverse clinical outcomes during transplantation. After surgery, dysmetabolism and stress response limit successful graft survival and can lead to primary or secondary graft dysfunction. In this clinical context, and given that a major problem in transplant medicine is that the demand for organs far exceeds the supply, a technological innovation such as a hemoadsorption system could greatly contribute to increasing the number of usable organ donors. The objectives of this review are to describe the specific advantages and disadvantages of the application of cytokine adsorption in the context of transplantation and examine, before and/or after organ transplantation, the benefits of the addition of a cytokine adsorption therapy protocol.
Lattice Dynamics, Transport and Thermoelectric Properties of Bi-Sb Alloys Obtained by Mechanical Alloying and Spark Plasma Sintering
Authors: Viennois Romain , Alvarez Laurent , Coulomb Loïc , El Mastour Yassine , Fabbiani Marco , Villeroy Benjamin , Bérardan David , Moll Adrien , Beaudhuin Mickaël
Published: December 2023

We report on the successful synthesis of Bi1−xSbx alloys via mechanical alloying followed by sintering via spark plasma sintering, and the study of their lattice dynamics by Raman spectroscopy as well as their transport and thermoelectric properties. We observed an upshift of the frequency of the Raman-active Eg vibrational mode with increasing Sb content but no significant change for the frequency of the Raman-active A1g vibrational mode. Conversely, the linewidth of the Eg vibrational mode did not change significantly with increasing Sb content, whereas a twofold increase was observed for the A1g vibrational mode. Moreover, we confirm the emergence of several new vibrational modes with Sb alloying that could be associated with Bi-Sb and Sb-Sb vibrations. Rather large magnetoresistance was observed for all samples at room temperature. From the Seebeck coefficients, we determined the energy bandgaps in our samples, which are larger than those in bulk compounds, presumably due to the electronic confinement effect. We report a rather large thermoelectric power factor of 2–3 mW/m.K2 and thermoelectric figure of merit ZT of 0.15–0.23 at room temperature. However, ZT values were not improved at room temperature compared to prior works because of the rather large thermal conductivity of 3.75–4.5 W/m.K at room temperature. We find a larger resistivity, Seebeck coefficient, and power factor for the samples sintered at 200 °C for 5 min than for the samples sintered at 220 °C for 15 min, but similar thermal conductivity, resulting in larger ZT for the samples obtained in the first conditions. The samples with low Sb content x = 0.05 have a lower power factor and larger thermal conductivity than the samples with x = 0.12 and x = 0.15 for the same sintering conditions, which results in lower ZT for x = 0.05.
Identification of Potential Plant-Derived Pancreatic Beta-Cell-Directed Agents Using New Custom-Designed Screening Method: Gymnema sylvestre as an Example
Authors: Al-Romaiyan Altaf , Persaud Shanta J. , Jones Peter M.
Published: December 2023

Background: Folk medicines are attractive therapeutic agents for treating type 2 diabetes mellitus (T2DM). Most plant extracts that have been suggested to restore β-cells function were tested in vivo. Some only have been tested in vitro to determine whether they have a direct effect on β-cells islets of Langerhans. Currently, there are no defined criteria for screening of β-cell-directed plant-based remedies as potential antidiabetic agents. Summary: In this review, we have identified certain criteria/characteristics that can be used to generate a “screening portfolio” to identify plant extracts as potential β-cell-directed agents for the treatment of T2DM. To validate our screening method, we studied the potential therapeutic efficacy of a Gymnema sylvestre (GS) extract using the screening criteria detailed in the review. Six criteria have been identified and validated using OSA®, a GS extract. By using this screening method, we show that OSA® fulfilled most of the criteria identified for an effective β-cell-directed antidiabetic therapy, being an effective insulin-releasing agent at nontoxic concentrations; maintaining β-cell insulin content by stimulating a concomitant increase in insulin gene transcription; maintaining β-cell mass by protecting against apoptosis; and being effective at maintaining normoglycemia in vivo in a mouse model and a human cohort with T2DM. Key messages: The present review has highlighted the importance of having a screening portfolio for plant extracts that have potential antidiabetic effects in the treatment of T2DM. We propose that this screening method should be adopted for future studies to identify new β-cell-directed antidiabetic plant derived agents.
Antimicrobial Effects of Plant-Based Supplements on Gut Microbial Diversity in Small Ruminants
Authors: Daniel Ian K. , Njue Obadiah M. , Sanad Yasser M.
Published: December 2023

Every year in the United States, approximately 48 million people are affected by bacterial illnesses that are transmitted through food, leading to 3000 fatalities. These illnesses typically stem from food animals and their by-products, which may harbor dangerous pathogens like Salmonella enterica, Listeria monocytogenes, enterohemorrhagic Escherichia coli O157:H7, and Campylobacter jejuni. Factors that contribute to contamination include manure used as a soil amendment, exposure to polluted irrigation water, and contact with animals. To improve food safety, researchers are studying pre-slaughter intervention methods to eliminate bacterial contamination in live animals. While small ruminants are vital to global agriculture and income generation for small farms, traditional feeding practices involve supplements and antibiotics to boost performance, which contributes to antibiotic resistance. Hence, researchers are looking for friendly bacterial strains that enhance both animal and human health without impacting livestock productivity. The global trend is to minimize the use of antibiotics as feed supplements, with many countries prohibiting or limiting their use. The aim of this review is to provide a comprehensive insight on the antioxidant capabilities, therapeutic attributes, and applications of bioactive compounds derived from sweet potato tops (SPTs), rice bran (RB) and radish tops (RTs). This overview provides an insight on plant parts that are abundant in antioxidant and prebiotic effects and could be used as value-added products in animal feed and pharmaceutical applications. This review was based on previous findings that supplementation of basal diets with natural supplements represents a multifaceted intervention that will become highly important over time. By remarkably reducing the burden of foodborne pathogens, they apply to multiple species, are cheap, do not require withdrawal periods, and can be applied at any time in food animal production.
Nano-Agrochemicals as Substitutes for Pesticides: Prospects and Risks
Authors: Ali Shehbaz , Ahmad Naveed , Dar Mudasir A. , Manan Sehrish , Rani Abida , Alghanem Suliman Mohammed Suliman , Khan Khalid Ali , Sethupathy Sivasamy , Elboughdiri Noureddine , Mostafa Yasser S. , Alamri Saad A. , Hashem Mohamed , Shahid Muhammad , Zhu Daochen
Published: December 2023

This review delves into the mesmerizing technology of nano-agrochemicals, specifically pesticides and herbicides, and their potential to aid in the achievement of UN SDG 17, which aims to reduce hunger and poverty globally. The global market for conventional pesticides and herbicides is expected to reach USD 82.9 billion by 2027, growing 2.7% annually, with North America, Europe, and the Asia–Pacific region being the biggest markets. However, the extensive use of chemical pesticides has proven adverse effects on human health as well as the ecosystem. Therefore, the efficacy, mechanisms, and environmental impacts of conventional pesticides require sustainable alternatives for effective pest management. Undoubtedly, nano-agrochemicals have the potential to completely transform agriculture by increasing crop yields with reduced environmental contamination. The present review discusses the effectiveness and environmental impact of nanopesticides as promising strategies for sustainable agriculture. It provides a concise overview of green nano-agrochemical synthesis and agricultural applications, and the efficacy of nano-agrochemicals against pests including insects and weeds. Nano-agrochemical pesticides are investigated due to their unique size and exceptional performance advantages over conventional ones. Here, we have focused on the environmental risks and current state of nano-agrochemicals, emphasizing the need for further investigations. The review also draws the attention of agriculturists and stakeholders to the current trends of nanomaterial use in agriculture especially for reducing plant diseases and pests. A discussion of the pros and cons of nano-agrochemicals is paramount for their application in sustainable agriculture.
Dynamic Scheduling Optimization Method for Multi-AGV-Based Intelligent Warehouse Considering Bidirectional Channel
Authors: Yu Chengwei , Liao Wenzhu , Zu Leting
Published: December 2023

With the implementation of AGV technology and automated scheduling, storage and retrieval systems have become widely utilized in warehouse management. However, due to the use of unidirectional channels, AGV movement is restricted, and detours may occur frequently. Additionally, as the number of AGVs increases, deadlocks can arise, which lead to delays in order packaging and a decrease in overall warehouse performance. Hence, this paper proposes a dynamic scheduling method for task assignment and route optimization of AGVs to prevent collisions. The routing optimization method is based on an improved A* algorithm, which takes into account the dynamic map as input. Moreover, this paper investigates highly complex collision scenarios in bidirectional channels. Through simulation experiments, it is evident that scheduling methods based on bidirectional channels offer a clear advantage in terms of efficiency compared to those based on unidirectional channels.
Intranasally Delivered Adenoviral Vector Protects Chickens against Newcastle Disease Virus: Vaccine Manufacturing and Stability Assessments for Liquid and Lyophilized Formulations
Authors: Farnós Omar , Martins Fernandes Paes Barbara Cristina , Getachew Belayneh , Rourou Samia , Chaabene Ameni , Gelaye Esayas , Tefera Takele A. , Kamen Amine A.
Published: December 2023

Newcastle disease (ND) remains a critical disease affecting poultry in sub-Saharan Africa. In some countries, repeated outbreaks have a major impact on local economies and food security. Recently, we developed an adenovirus-vectored vaccine encoding the Fusion protein from an Ethiopian isolate of Newcastle disease virus (NDV). The adenoviral vector was designed, and a manufacturing process was developed in the context of the Livestock Vaccine Innovation Fund initiative funded by the International Development Research Centre (IDRC) of Canada. The industrially relevant recombinant vaccine technology platform is being transferred to the National Veterinary Institute (Ethiopia) for veterinary applications. Here, a manufacturing process using HEK293SF suspension cells cultured in stirred-tank bioreactors for the vaccine production is proposed. Taking into consideration supply chain limitations, options for serum-free media selection were evaluated. A streamlined downstream process including a filtration, an ultrafiltration, and a concentration step was developed. With high volumetric yields (infectious titers up to 5 × 109 TCID50/mL) in the culture supernatant, the final formulations were prepared at 1010 TCID50/mL, either in liquid or lyophilized forms. The liquid formulation was suitable and safe for mucosal vaccination and was stable for 1 week at 37 °C. Both the liquid and lyophilized formulations were stable after 6 months of storage at 4 °C. We demonstrate that the instillation of the adenoviral vector through the nasal cavity can confer protection to chickens against a lethal challenge with NDV. Overall, a manufacturing process for the adenovirus-vectored vaccine was developed, and protective doses were determined using a convenient route of delivery. Formulation and storage conditions were established, and quality control protocols were implemented.
Origen y propósito de los nabos hervidos de Rómulo
Authors: Ferriol Ezequiel
Published: December 2023

Desde la publicación en 1864 del comentario de Franz Bücheler a la Apocolocyntosis de Séneca, la representación de Rómulo devorando nabos hervidos en el cielo ha sido aceptada generalmente como una cita textual de un supuesto fragmento de las Sátiras de Lucilio donde este último (y, por consiguiente, Séneca) se burla ya sea de Rómulo, ya sea de Ennio y de la seriedad de sus Annales.

En la presente contribución, argumentaré en contra de este punto de vista. En primer lugar, sostendré que la atribución a Lucilio de la frase [Romulus in caelo] ferventia rapa vorare es insostenible. Luego, que el autor de esta frase es, en realidad, Séneca. En tercer lugar, que la representación de Rómulo devorando nabos hervidos en el cielo es, a pesar de su burlesca crudeza, un símbolo de los valores tradicionales y, por último, que Séneca la utiliza con una intención favorable como medio de oponerla al ejemplo negativo de Claudio. Para demostrar estas afirmaciones, analizaré el origen y evolución de esta representación de Rómulo apoyándome en Malavolta (2017) y en los vínculos de la sátira menipea de Séneca con el pensamiento de Cicerón.
Ibis de Ovidio: tiempos y espacios de la escritura del exilio
Authors: Radiminski Maricel
Published: December 2023

La invectiva elegíaca Ibis, dedicada al homónimo enemigo del enunciador ovidiano y escrita desde el exilio del poeta, despliega sus versos al mismo tiempo que reflexiona acerca de su propio estatus genérico. Dicha reflexión parece vincularse con tres tiempos y espacios de escritura que proponen diferentes tipos de literatura: la escritura del poema en cuestión, llevada a cabo en Tomi; la escritura anterior al exilio, cultivada en Roma; y la escritura reservada para el futuro, prevista también en el exilio y prometedora de yambos. Repasaremos estas tres instancias a fin de determinar sus implicancias metaliterarias.
La concepción hilemórfica del Estado soberano moderno. Una perspectiva filosófica
Authors: Gaiada Griselda
Published: December 2023

En este artículo desarrollamos la hipótesis de que el Estado soberano moderno responde a una “concepción hilemórfica” que se impuso tras la Paz de Westfalia (1648) como resultado de un largo proceso de reformulación de las representaciones filosóficas de lo político. Como veremos, el Estado así concebido ya no permitirá pensar la esencia de lo político ni como un alma que puede in extremis mudar de expresión territorial –o incluso sostener su unidad en la diáspora–, ni como un cuerpo que admite pluralidad de principios rectores. Más aún, la “nueva entidad política” forjada por la filosofía del Barroco –en manifiesta continuidad con la tradición que remonta a los griegos– sigue siendo, pese al paso del tiempo, el nervio del actual derecho internacional, a punto tal que los rasgos fundamentales que este atribuye a la soberanía son a nuestro entender la transposición jurídica de dicha composición hilemórfica.
Land cover change analysis of buffer areas in New Capital City of Nusantara, Indonesia: A cellular automata approach on satellite imageries data
Authors: Claire Maria Shawna Cinnamon , Putri Salwa Rizqina , Wijayanto Arie Wahyu
Published: December 2023

The proposed plan to move Indonesia's capital city to the New Capital City of Nusantara in East Kalimantan Province undoubtedly requires careful efforts to ensure food supply for the population. Population migration to the new capital may pose a food security challenge. To address this fundamental issue, one of the most crucial approaches is to establish buffer areas that can support the food needs of the new capital. The currently existing official Area Sampling Frame survey conducted by the government to assess food vulnerability faced several limitations, including weather conditions, field terrain variations, and high cost. In this study, we propose the utilization of remote sensing satellite imagery data in buffer areas to analyze changes and predict future land cover, which can provide valuable data for assessing food availability. We investigate the integration of a Cellular Automata method with the two most popular analytical methods of classical Logistic Regression and data-driven Artificial Neural Networks, known as CA-LR and CA-ANN, to identify and map land cover changes in the new capital buffer zones. Our findings reveal that both combined methods, CA-LR and CA-ANN, yield fairly promising results, with correctness and kappa statistic values exceeding 80%. Prediction results indicate that buffer areas are predominantly covered by trees, while built-up areas are still limited. The flooded vegetation cover, including rice fields, is predicted to decrease by 2024. This should be a matter of concern for stakeholders, considering the construction of the new capital city is still ongoing and the number of migrants is expected to keep rising.
A Geovisualization Dashboard of Granular Food Security Index Map using GIS for Monitoring the Provincial Level Food Security Status
Authors: Syaputri Dwi Karunia , Josaphat Bony Parulian , Wijayanto Arie Wahyu
Published: December 2023

This study aims to build a web-based interactive geovisualization dashboard from a granular food security index map using satellite imagery and other geospatial big data. The map dashboard is built using a two-dimensional (2D) data visualization approach. Making a two-dimensional map using QuantumGIS (QGIS) tools, displayed in the form of WebGIS with the plugin used "Qgis2web" based on javascript leaflets. Once included in WebGIS, interactive visualizations are displayed on websites with interfaces based on hypertext markup language (HTML), cascading style sheets (CSS), and JavaScript (JS). The dashboard map is equipped with interactive features such as legend, click grid, zoom, show me where I am, measure distance, and search. Therefore, the dashboard map can be used to monitor the food security index, search for food security index areas, as well as geographical identification of food security index areas which are useful for supporting the analysis of decision-making or policies by the government regarding food security strategies.
Comparative Analysis of Retriever and Reader for Open Domain Questions Answering on BPS Knowledge in Indonesian
Authors: Widodo Sulisetyo Puji
Published: December 2023

Enumerators from Badan Pusat Statistik (BPS) still often encounter problems in finding solutions to cases encountered during censuses or surveys. Even though knowledge lists have been created and collected in various systems such as QA and knowledge management systems, enumerators still need to find appropriate answers from long and complex knowledge search results. On the other hand, Open-domain Question Answering (OpenQA) is capable of identifying answers to natural questions based on large-scale documents. OpenQA has main components, namely Retriever and Reader. For Retriever tasks, Dense Retrieval (DR) is proven to outperform traditional sparse retrieval such as TF-IDF or BM25. However, other research actually shows that BM25 is superior to DR in terms of accuracy. In this study, we compared DR and BM25 separately and DR+BM25 as a retriever. Additionally, we combine and evaluate several enhanced language models as Readers. In this way, a model with the best combination of Retriever and Reader can be obtained to be implemented in search systems such as QA and knowledge management systems.
Unlocking potential of data: A localized data-driven approach for stunting reduction in South Kalimantan Province
Authors: Rizkiah Farah
Published: December 2023

This study addresses the issue of stunting in South Kalimantan Province, where high stunting prevalence rates persist. Through a comprehensive analysis of factors influencing stunting prevalence, predictive modeling using machine learning, and clustering analysis of districts based on stunting rates, the research aims to support the provincial government in formulating effective and sustainable strategies. The findings highlight influential factors such as HDI, poverty rates, immunization coverage, breasfed babies, number of uninhabitable houses, and access to clean water. The study also utilise machine learning to build model that aids in predicting future stunting prevalence, while clustering analysis categorizes districts into distinct groups. These insights guide the government in prioritizing interventions, setting prevalence targets, and determining strategic areas for stunting reduction efforts.
Development of FASIH Application for the Badan Pusat Statistisk using Flutter Framework
Authors: Prasetia Riofebri Prasetia , Maghfiroh Lutfi Rahmatuti Maghfiroh
Published: December 2023

One of the data collection methods used by the Badan Pusat Statistik (BPS) is Computer Assisted Personal Interviewing (CAPI). Currently, CAPI, known as FASIH, is continuously updated by BPS using the Kotlin programming language, which can run on the Android platform. It is possible that FASIH will be needed in a multiplatform form. However, there is an alternative for multiplatform application development, namely Flutter, which can be used in the development of FASIH. Nevertheless, BPS has not conducted any study on the development of the FASIH application using Flutter, hence the strengths and weaknesses of implementing this technology in FASIH application development remain unknown. Therefore, the author aims to conduct a study on the development of the FASIH application utilizing Flutter. The application development is carried out using the Rapid Application Development (RAD) Prototyping method. The resulting application is tested using black box testing and performance testing using a third-party application, Apptim. The black box testing results indicate that the application meets the functional requirements of stakeholders. In terms of performance, the Kotlin version of FASIH outperforms the Flutter version. However, Flutter has an advantage in accelerating development time. Additionally, concerning user interface development, the Flutter version of the FASIH application can run on multiple platforms. Nevertheless, further integration is required to ensure the proper functioning of the Flutter version of the FASIH application.
FACTORS RELATED TO THE ATTITUDE OF PREGNANT WOMEN IN THE USE OF COMPLEMENTARY THERAPIES IN PREGNANCY
Authors: Suparni Suparni , Aisyah Risqi Dewi
Published: December 2023

During pregnancy, a woman experiences physiological changes that require therapy/treatment. One of the therapies used during pregnancy to overcome discomfort during this period is complementary therapy. The use of complementary therapies by pregnant women is influenced by several factors. Therefore, this study aims to determine the factors related to the attitudes of pregnant women in utilizing complementary therapies during pregnancy. The purpose of the study was to determine the relationship of knowledge, perceptions of pregnant women, and family support to the attitudes of pregnant women in the use of complementary therapies during pregnancy. This research is a cross-sectional questionnaire-based descriptive research study conducted on pregnant women who access primary and secondary services in the Pekalongan Regency working area. The sampling technique used in this study was proportional random sampling. The estimated size according to the data analysis design carried out is a multivariate analysis involving 4 independent variables. This study involved 60 research subjects with inclusion criteria, namely pregnant women who can read and exclusion criteria for pregnant women who have pregnancy danger signs. Pregnant women with a high level of knowledge have a 7,244 times higher chance of utilizing complementary therapy, which is related to the opportunity for pregnant women to detect early danger signs during pregnancy. Complementary therapy is a solution to deal with discomfort in pregnant women during pregnancy and can even cure some diseases. The use of complementary therapies is supported by several factors in the pregnant woman's environment. For this reason, it is necessary to understand the use of complementary therapies so that the use of complementary therapies can be maximized for pregnant women.  Keywords: complementary, pregnancy women, knowledge
Methodological approaches to identifying nato breakthrough technologies
Authors: Kupchyn A. V. , Matsyk O. O. , Demchenko Ye. Ya. , Borohvostov I. V. , Melnik O. D.
Published: December 2023

This scientific work has a review nature and is aimed at systematizing, generalizing and highlighting the scientific and methodological foundations of NATO in technological foresight to identify breakthrough technologies.
The article describes general approaches, main methodological aspects and technology assessment indicators, and provides common and different features in foresights 2020 and 2023. In particular, the process of technology assessment according to the Gartner cycle and levels of technological maturity is reflected.
A separate block presents the results of a technological foresight with a forecast horizon until 2043. At the same time, the levels of technological maturity and potential impact on NATO capabilities were assessed, and the approximate time horizons for technology readiness were determined. Each scientific and technological area is given a brief description and decomposition into technological groups is shown.
الترجيح بالاحتياط عند الإمام يحيى بن حمزة من كتابه الانتصار في مسائل الطهارة والصلاة دراسة تطبيقية
Authors: شباله مطيع محمد عبده أحمد
Published: December 2023

يهدف هذا البحث إلى التعريف بالإمام يحيى بن حمزة، وحياته العلمية. وتم تقسيمه إلى: تمهيد ومبحثين وخاتمة، ففي التمهيد تم التعريف بمصطلحات البحث، وبالإمام يحيى بن حمزة، وفي المبحث الأول ظهرت ترجيحات الإمام يحيى بن حمزة بالاحتياط في أحكام الطهارة. وفي المبحث الثاني تم إبراز ترجيحات الإمام يحيى بن حمزة بالاحتياط في أحكام الصلاة. وكان في الخاتمة أبرز النتائج والتوصيات والمقترحات. وقد توصل البحث إلى أن الإمام يحيى بن حمزة رجح في المسائل الخلافية مورد الدراسة بدليل الاحتياط، حيث كان هذا الدليل حاظرًا فيها، وقد كان شأنه في ذلك شأن جمهور العلماء، كونهم يرون العمل بالاحتياط، وخاصة في العبادات. وقد كان السبب الظاهر للترجيح بدليل الاحتياط عند الإمام يحيى بن حمزة في المسائل مورد الدراسة هو: تعارض الأدلة بين الحاظر والمبيح، والقاعدة لديه: تقديم الحاظر على المبيح احتياطاً للعبادة. كما ظهر من خلال هذا البحث: أن ابن حزم الظاهري (ت: 456هـ) لا يرى الاحتجاج بدليل الاحتياط، وخاصة إذا بني على الظن، وقد ظهر ذلك في مواطن متعددة من خلال كتابه: المحلى، وإن كان يحض على الورع عموماً.
منصات التواصل الاجتماعي وأثرها على الاتصالات التسويقية المتكاملة دراسة حالة شركة يمن موبايل للهاتف النقال
Authors: المحمودي فضل محمد إبراهيم , المسني معاذ حسن عبده
Published: December 2023

هدفت هذه الدراسة إلى التعرف على طبيعة تأثير منصات التواصل الاجتماعي المتمثلة في: (إدارة الموقع ومحتوى الموقع) في تعزيز الاتصالات التسويقية المتكاملة في شركة يمن موبايل للهواتف المحمولة. ولتحقيق أهداف الدراسة تم استخدام المنهج الوصفي التحليلي من خلال تصميم استبانة تضمنت محاور الدراسة. وتكون مجتمع الدراسة من العاملين في الأقسام المعنية بالتسويق والمبيعات وخدمة العملاء والعلاقات العامة في شركة يمن موبايل للهاتف النقال بأمانة العاصمة، البالغ عددهم 150 موظفًا. تم اختيارهم باستخدام أسلوب الحصر الشامل. وتوصلت الدراسة إلى بعض النتائج أبرزها: هناك تأثير كبير لمنصات التواصل الاجتماعي في أبعادها (إدارة الموقع، محتوى الموقع) في تعزيز الاتصالات التسويقية المتكاملة في يمن موبايل. وأنها تستعمل منصات التواصل الاجتماعي في الترويج لخدماتها.
Psicologia dialógica
Authors: Gomes Ramon , Dazzani Maria Virgínia Machado , Marsico Giuseppina
Published: December 2023

O objetivo deste artigo é propor uma relação teórica entre o conceito da exotopia bakhtinana e a posições de Eu. A Teoria do self dialógico concebe a mente como uma multiplicidade dinâmica de posições de Eu relativamente autônomas fundamentada, especialmente, na filosofia dialógica de Michael Bakhtin e na teoria do self de William James. Cada posição de Eu, na minissociedade da mente, tem a capacidade de “ver além” do que qualquer outra poderia, pois, no tempo-espaço, cada posição de Eu pode ocupar um lugar que é único. A exotopia pressupõe a extralocalização dessas posições de Eu, umas diante das outras, o que estabelece a viabilidade das interações dialógicas. É essa exotopia que conduz à nossa possibilidade de responder a uma outra voz interna ou externa. Essa condição espacial caracteriza toda relação intra ou heterodialógica, assim como a possibilidade de aparecimento de novidade de significados no self. Um caso empírico de um adolescente é apresentado para ilustrar o nascimento de nova posição de Eu no processo de escolarização a partir do aumento da exotopia no self.
trajetória da guarda-redes e árbitra no futebol moçambicano
Authors: Guimarães Gustavo Cerqueira , Fernandes Eunice Marisa , Silvino Nimwive Agostinho
Published: December 2023

Entrevista a Elsa da Graça Mavile, árbitra e ex-goleira moçambicana, sobre os desafios de sua trajetória no futebol, realizada no Instituto Guimarães Rosa, em Maputo, em 2022, como parte do projeto da exposição de artes Futebol e memória: guarda-redes do Brasil e de Moçambique, exibida ao longo da Copa do Mundo no Qatar. Elsa nasceu em Maputo, em 1982, onde começou a jogar bola com meninos e a participar de torneios femininos entre 1997 e 2007. Chegou à baliza da seleção nacional em 2002. Hoje, exerce a arbitragem.
Analisis mikroba pada penampungan air penyakit kulit di basement trainer Yusuf Abdussatars milik Kabupaten Lombok Barat
Authors: Getas I wayan , Mandayani Baiq Dinda Annas Tasya , Anggit Jiwantoro Yudha , Kristinawati Erna
Published: December 2023

Penyakit kulit merupakan kelainan pada kulit yang dapat disebabkan oleh infeksi mikroba patogen seperti bakteri, jamur, parasit, dan virus. Selain itu, penyakit kulit dapat disebabkan oleh sanitasi lingkungan yang buruk, seperti ketersediaan air bersih. Ketersediaan air bersih di lingkungan pesantren mempengaruhi kondisi kesehatan santri. Minimnya ketersediaan air bersih memberikan sarana bagi mikroba untuk hidup dan berkembang seperti mikroba patogen yang dapat menyebabkan penyakit kulit. Tujuan dari penelitian ini adalah untuk mengetahui jenis mikroba penyebab penyakit kulit pada bak penampungan air di Pondok Pesantren Yusuf Abdussatar Kediri Kabupaten Lombok Barat. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional dan dianalisis secara deskriptif. Hasil penelitian ini teridentifikasi bakteri Aeromonas hydrophilla pada air tandon 1, 2, 5 dan 6, Escherichia coli pada air tandon 1, 3, 4 dan 6 dan bakteri Plesiomonas shigelloides pada air tandon 6 dan jenis jamur yang teridentifikasi adalah jamur Aspergillus. sp. di penampungan air 1 dan 6 di Pesantren Yusuf Abdussatar, Kediri, Kabupaten Lombok Barat. Kesimpulan penelitian ini adalah tidak ditemukannya jenis mikroba penyebab penyakit kulit di Pondok Pesantren Yusuf Abdussatar Kediri Kabupaten Lombok Barat.