bluuebunny/crossref_metadata_2025 huggingface dataset:
Cu Single-Atom Embedded g-C3N4 nanosheets Rehabilitate Multidrug-Resistant Bacteria Infected Diabetic Wounds via Photoswitchable Cascade Reaction
Authors: Li Peng , Sun Xichen , Zhu Pengqi , Tang Liuyan , Wang Pengfei , Li Ningning , Wang Qing , Lou Yan-Ru , Zhang Yuezhou
Published: February 2025

To tackle elevated blood glucose, multidrug-resistant (MDR) bacterial infections, and persistent inflammation in diabetic wounds, we present a therapeutic strategy that employs a photoswitch-controlled catalytic cascade reaction, utilizing a photocatalytic material engineered through the synergistic regulation of nitrogen vacancies and single-atom embedding. The nitrogen vacancies in g-C3N4 promise the photocatalytic glucose oxidation to H2O2 and facilitate its subsequent conversion into hydroxyl radicals (•OH) through a photocatalytic cascade reaction with Cu single-atom embedded g-C3N4 nanosheets (Cu/CN). Concurrently, the •OH and superoxide anions (•O2⁻) are obtained by photocatalytic water splitting over Cu/CN. Over 99.9% antibacterial activity and effective biofilm inhibition are achieved via photocatalytic cascade reaction. In the dark, excess ROS are scavenged by Cu/CN, reducing inflammation of wounds and promoting polarization of M2 macrophages. This photoswitchable cascade reaction effectively treated MDR bacterial-infected diabetic wounds, highlighting its potential for antibiotic-free diabetic wound therapy and its promising prospects for clinical applications.
The effect of mind- and body-based interventions on poststroke depression and its neural mechanisms: A systematic review and meta-analysis
Authors: HOU Rangchun , YANG Peter Bohao , VIDAÑA Dalinda Isabel SANCHEZ , ZHANG Jack Jiaqi , ZENG Roy Rongyue , CHAN Jackie Ngai-Man , FUNG Timothy Kai-Hang , NGAI Shirley Pui-Ching , LAU Benson Wui-Man , FONG Kenneth N. K.
Published: February 2025

Post-stroke depression (PSD) is recognized as the most common psychiatric disorder following a stroke, impacting the subsequent recovery and quality of life of stroke survivors. In recent years, physical activities and mindfulness have been proven to improve depression, however, it remained unknown whether those interventions were also effective in the treatment of PSD. This systematic review aims to assess the effects of mind- and body-based interventions on PSD and their underlying neural mechanisms. The systematic review (PROSPERO registration number: CRD42024514565) searched CINAHL, Cochrane, PsycINFO, PubMed, and Scopus up to March 11, 2024, focusing on English-language studies. Inclusion criteria encompassed randomized controlled trials of stroke patients with depression using validated assessment tools, targeting body-based, mind-based, or mind-body interventions, while excluding psychological or counseling interventions and passive movements. Two authors conducted data extraction with checks for accuracy, and risk of bias was assessed using the PEDro scale, which evaluates study design and methodology, yielding a maximum score of 10 points. Data extraction and risk of bias assessment were conducted by independent reviewers. A total of 68 studies were included, involving 6,825 participants, and 54 of these studies were included in the meta-analysis. The average PEDro score of 6.51 indicates good methodological quality, with combined interventions scoring highest at 7.44, highlighting variability among the studies. Meta-analysis results demonstrate that all mind- and body-based interventions have a significant impact on PSD (p < 0.05), with effect sizes as follows: all mind- and body-based interventions (n = 66, Hedges’ g = -0.572), mind-based interventions (n = 4, Hedges’ g = -0.549), body-based interventions (n = 52, Hedges’ g = -0.532), and combined interventions (n = 10, Hedges’ g = -0.805). The systematic review and meta-analysis revealed that all mind- and body-based interventions significantly improved post-stroke depression, and combined interventions are more effective than mind-based or body-based interventions alone. It is suggested to integrate additional mindfulness elements into the daily exercises of stroke survivors in clinical practice can further alleviate depressive symptoms.
Linking Parkinson’s disease and Alzheimer’s disease: A Mendelian Randomization Study on Causal Relationships and Clinical Implications
Authors: Kuruvilla Joshua , Yong Yuan Ting , Lee Wei Jun , Yap Kenneth , Deng Xiao , Tan Eng-King , Xiao Bin
Published: February 2025

Parkinson's Disease and Alzheimer's Disease are the two most common neurodegenerative conditions. Contemporary research has unraveled distinct key mechanisms that account for two diseases, although disturbance of pathways that responsible for Parkinson's Disease has been found to be implicated in Alzheimer's Disease, and vice versa. In order to investigate if there is causal relationship between these two intertwined diseases, we conducted a two-sample Mendelian randomisation analysis encompassing 482,730 PD individuals and 218,792 AD individuals. Using SNPs from publicly available genome-wide association study datasets, we chose instrumental variables for a two-sample MR analysis while adhering to important Mendelian randomisation assumptions. The primary analysis using the Inverse Variance Weighted method indicated a significant causal effect of Parkinson's Disease on Alzheimer's Disease (OR = 1.071766, 95% CI: 1.0062448, 1.141554; p = 0.03218492). The IVW analysis tested the bi-directional relationship between Alzheimer's disease (finn-b-G6_ALZHEIMER) and Parkinson's disease (ieu-b-7), with no significant evidence suggesting reverse causation. Sensitivity analyses, including heterogeneity tests, MR-Egger regression, leave-one-out, and reverse causation analysis, validated the robustness of the findings, showing no evidence of pleiotropy or. Clinically, these data suggest that Parkinson's Disease patients may benefit from early Alzheimer's Disease screening and interventions, which could improve individualized treatment approaches and public health initiatives. This study underlines the ability of genetic insights to influence integrated care approaches, ultimately improving patient outcomes with neurodegenerative diseases.
On Quantitative Evaluations on Harmonic and Anharmonic Lattice Thermal Capacity of Polymers
Authors: Ligatchev Valeri
Published: February 2025

So-called ‘Generalized Skettrup Model(s)’ (GSMs) of different (1D, 2D, 3D) spatial dimensionalities are implemented at quantitative evaluations on temperature-dependent harmonic and anharmonic fractions of lattice thermal capacity of polyethylene and polypropylene with crystalline and/or amorphous atomic structures of limited spatial extents. Basic equations of the GSM take into account explicitly quantization effects of the single-particle and many-particle energy levels of spatially confined (within the 1D, 2D and/or 3D structural fragments of polymers) conventional longitudinal acoustic (LA), transverse acoustic (TA), and optical phonons. The harmonic lattice thermal capacity of 1D and 3D polymers is evaluated entirely based on single-particle (fundamental) states of the confined LA, TA and optical phonons. Statistical characteristics of many-particle states of the LA and TA phonons are obtained based on concept of many-particle vibrational density-of-states, introduced by the author of this article in 1995. Those characteristics define features of temperature-dependent anharmonic lattice capacities of 1D, 2D and 3D versions of the GSM in an essentially ‘non-perturbative’ manner. Anisotropic effects in 3D crystalline polymers are taken into account via evaluation of anisotropic sound velocities of conventional thermal waves, confined within 3D crystalline fragments of those polymers. Such evaluations have been carried out quantitatively for orthorhombic 3D polyethylene via implementation of the Christoffel Matrix formalism. Simulated temperature-dependent lattice thermal capacities are compared with their experimental counterpart for the polyethylene and polypropylene as well as with predictions of the Tarasov’s Equations and those of the ‘three-band’ model.
Single Cell Spatial Transcriptomics of the Murine Embryonic Palate Links Pax9 to Patterning and Organization of Extracellular Matrix Components
Authors: Piña Jeremie Oliver , Raju Resmi , Stipano Evan , Myo Aye Chan , Wang Ziyi , Ono Mitsuaki , Chattaraj Parna , Furukawa Masae , D’Souza Rena N.
Published: February 2025

Despite advances in understanding the morphological disruptions that lead to defects in palate formation, the precise perturbations within the signaling microenvironment of palatal clefts remain poorly understood. To explore in greater depth the genomic basis of palatal clefts, we designed and implemented the first single cell spatial RNA-sequencing study in a cleft palate model, utilizing the Pax9-/- murine model at multiple developmental timepoints, which exhibits a consistent cleft palate defect. Visium HD, an emerging platform for true single-cell resolution spatially resolved transcriptomics, was employed using custom bins of 2x2 µm spatial gene expression data. Validation of spatial gene expression was then validated using custom designed Xenium In Situ mRNA spatial profiling and RNAscope Multiplex assays. Functional enrichment analysis revealed a palate cell-specific perturbation in Wnt signaling effector function in tandem with disrupted expression of extracellular matrix genes in developing mesenchyme. As a key step toward laying the framework for identifying key molecular targets these data can be used for translational studies aimed at developing effective therapies for human palatal clefts.
Construction and clinical application of the cochlear automatic segmentation and measurement model based on U-HRCT
Authors: Yang Dewu , Zhang Mengshi , Feng Yili , Han Shuguang , Tang Ruowei , Zhuo Li , Zhang Ye , Zhao Pengfei , Li Xiaoguang , Wang Zhenchang , Yin Hongxia
Published: February 2025

Objectives
In order to improve the accuracy and efficiency of data acquisition for cochlear structure, this study built an intelligent segmentation and automatic measurement model of cochlear based on U-HRCT to solve the difficulty of performing an accurate preoperative evaluation of the cochlea.
Methods
The data of 86 patients (172 ears in total) who received U-HRCT and were diagnosed with normal ears were retrospectively collected. In this study, TransUnet neural network was used to construct automatic segmentation model of cochlear, 7 direct measurement indexes were selected and 3 indirect measurement indexes were defined. The effect of automatic segmentation was evaluated by subjective method, compared with manual measured data, and the influencing factors of cochlear structure were analyzed by multiple linear regression method. Finally, the Violin Plot method is used to calculate the normal value range of cochlear structural parameters.
Results
The index of automatic segmentation DSC reached 98%, and the results of automatic measurement were consistent with those of manual measurement (P > 0.05). Except for regularity parameters CCR and HRD, cochlear structural parameters had high correlation with gender (P < 0.05), and except volume related parameters VOL and VRD, cochlear structural parameters had low correlation with age (P > 0.05). Except VRD, the correlation between the cochlear structure parameter and the location was low (P > 0.05).
Conclusions
This study built an automatic segmentation and measurement model of cochlear structure, obtained the reference value range of cochlear structure parameters, and provided reference data for clinical diagnosis and treatment.
Clinical relevance statement
The above indexes have important reference value for the automatic identification of cochlear structural abnormalities in clinic, and in-depth data mining of case samples will be carried out in subsequent studies.
An Integrative Model of Single Cell Transcriptomic States for Triple-Negative Breast Cancer
Authors: Samuelsson Erik Reinhold , Francis Roy , Hu Taobo , Nilsson Mats
Published: February 2025

Triple-negative breast cancer (TNBC), an aggressive and highly heterogeneous subtype of breast cancer, poses significant challenges for treatment due to its molecular diversity and resistance to standard therapies. Accounting for 10–20% of all breast cancer cases, TNBC lacks specific biological markers, making it difficult to classify and treat effectively. Traditional approaches based on bulk RNA sequencing obscure intratumoral heterogeneity and fail to capture distinct cellular states within tumors. In this study, we constructed a comprehensive single-cell transcriptomic map of TNBC by analyzing a cohort of published TNBC patient datasets, identifying nine transcriptomic states, or metaprograms, which capture the core behaviors of TNBC cells, including cancer stem cell properties, epithelial-to-mesenchymal transition (EMT), immune modulation, metabolic adaptation, and vasculogenic mimicry. We observed that these metaprograms are variably expressed within and across patient tumors, underscoring the complexity of TNBC. By integrating TNBC-specific metaprograms with established breast cancer subtypes, we found significant prognostic associations, with specific metaprograms correlating with poor survival outcomes. This study highlights the need for single-cell approaches to uncover TNBC’s molecular heterogeneity and suggests that metaprogram-based classification could facilitate more precise therapeutic interventions.
BKT300: A Novel Anti-Leukemic Small Molecule Targeting the Protein Regulator of Cytokinesis 1 (PRC1) Pathway
Authors: Peled Amnon , Abraham Michal , Wald Hanna , Hay Ophir , Hagbi Shira , Gamaev Lika , Monin Jonathan , Borthakur Gautam , Ayoub Edward , Andreeff Michael , Rosenfeld Rakefet , Eizenberg Orly , Aharon Arnon
Published: February 2025

Protein regulator of cytokinesis 1 (PRC1) is frequently overexpressed in various cancers and is associated with poor prognosis. BKT300 is a small molecule shown to selectively inhibit leukemic cell migration and survival by targeting the PRC1 pathways. The current work aimed to examine the role of PRC1 in acute myeloid leukemia (AML) and to assess the impact of BKT300, a small molecule PRC1 inhibitor, on AML cell viability and tumor growth in mouse xenograft AML models. BKT300 directly bound PRC1, resulting in disrupted actin and microtubule formation, G2/M cell cycle arrest, mitotic catastrophe and apoptosis via the caspase-3 pathway in AML cells. BKT300 inhibited PRC1 dephosphorylation at T481, downregulated CDC25C and upregulated p21, effectively halting the cell cycle and inhibiting leukemic cell proliferation while sparing normal cells. PRC1 was found to be overexpressed in AML patients and cell lines, with high levels associated with reduced overall patient survival. In addition, PRC1 expression levels correlated with BKT300 efficacy. BKT300 treatment led to 98% of tumor growth inhibition and 89.4% of tumor regression in mouse xenograft AML models, without notable impacts on normal hematopoiesis or biochemistry, even at high doses. As a first-in-class targeted therapy, BKT300 presents a promising new treatment option for advanced AML.
Cannabis Use in Adults with Neuropathic versus Non-Neuropathic Pain
Authors: Laroya Carl Joshua , Smith Crystal Lederhos , Bindler Ross J. , McDonell Michael , Lewis Jamie , Wilson Marian
Published: February 2025

Introduction: Cannabis has been decriminalized by many states and shows promise in treating both neuropathic and non-neuropathic pain through its interaction with the endocannabinoid system and anti-inflammatory effects. This study examines differences in cannabis use in adults with a primary condition of neuropathic versus non-neuropathic chronic pain.
Materials and Methods: Cross-sectional survey data collected demographics and patient-reported outcomes including pain intensity and interference. Information regarding the type and frequency of cannabis-product use was also recorded. Participants were stratified into groups based on their most bothersome type of pain: neuropathic and non-neuropathic. Between group statistics assessed for differences.
Results: Our sample consisted of 104 participants (61.5% female); with 36.5% reporting their most bothersome pain being neuropathic and 63.5% being non-neuropathic. Participants with neuropathic pain used cannabis and cannabis-based products significantly more days over the previous month and, when used, significantly more often per day.
Discussion: This study found that adults with neuropathic pain used cannabis, especially Tetrahydrocannabinol-only (THC) and THC/Cannabidiol (CBD) combination products, more frequently than those with non-neuropathic pain. Those with neuropathic pain also reported higher levels of pain intensity and interference. Further longitudinal research is needed to confirm whether increased use of THC-rich cannabis provided symptom relief for adults with neuropathic pain.
Dietary mineral intake was correlated with seral HDL-C in patients with type 2 diabetes
Authors: Li Wenmin , Shi Yingying , Xu Deyi , Yang Haofan , Zheng Wenhao , Wang Liang , Xu Lin , Lei Tao , Lu Jun
Published: February 2025

Background
While dietary interventions are critical for managing diabetes, there is limited research on the role of specific minerals in regulating lipid metabolism. This study aims to examine the correlation between dietary mineral intake and serum lipid profiles in patients with type 2 diabetes.
Methods
Daily mineral intake was accessed using a validated dietary questionnaire administered to 149 subjects. Partial correlation and multivariable linear regression analysis were conducted to examine the relationship between daily mineral intake and serum lipid profiles.
Results
According to the Dietary Nutrient Reference Intakes (DRI) for Chinese Residents, daily intake of calcium, zinc, potassium, and dietary fiber was significantly lower in both men and women (all P < 0.001). In contrast, sodium, iron and iodine intake were elevated. Partial correlation analysis indicated that daily intake of calcium, iron, iodine, zinc and selenium was positively associated with serum high-density lipoprotein cholesterol (HDL-C) (P < 0.05), whereas dietary iodine intake was negatively related to HDL-C (r= -0.181, P = 0.049). Multivariable linear regression analysis showed that dietary intake of calcium, iron, iodine, zinc and selenium was significantly associated with HDL-C after adjusting for covariates (all P < 0.05). However, there existed not significant correlation of dietary mineral intake with total cholesterol, low-density lipoprotein cholesterol, or triglyceride.
Conclusions
The dietary mineral intake of patients with type 2 diabetes was largely suboptimal. Dietary calcium, iron, zinc and selenium intake were positively associated with serum HDL-C, suggesting a potential benefit for lipid homeostasis in this population.
Automatic Cervical Cross-Sectional Area Measurement in 3T MR Images: Case of Healthy Human Spinal Cord
Authors: Boushila Tayssir , Sahnoun Mouna , Bouattour Nadia , Dammak Mariem , Kallel Fathi
Published: February 2025

Precise measurement of Spinal Cord Cross-Sectional Area (SC-CSA) is crucial for monitoring SC health state and diagnosing neurodegenerative diseases such as Multiple Sclerosis (MS), Devic Neuromyelitis Optica (DNMO), and Amyotrophic Lateral Sclerosis (ALS) progression. However, accurate measurement of SC-CSA is challenging due to many factors such as SC curvature, patient positioning, segmentation methods, and the limitations of Magnetic Resonance Imaging (MRI) resolution.

Traditional methods that rely on vertebral levels as reference suffer from intersubject variability and limited reproducibility. In this study, we propose a novel landmarks-based method for automated SC-CSA measurement. The proposed approach, relying on consecutive spinal nerves’ midpoints as anatomical reference, offers more precise spinal segment delimitation and consistent SC-CSA measurements.

We validated the effectiveness and robustness of our method using two public datasets comprising MR Images of healthy individuals covering all cervical levels and for three different head positions. Experimental results demonstrated that the proposed SC-CSA measurement method could be considered as a useful tool for potential clinical applications
Potential Of Agricultural By-Products And Waste As Ruminant Animal Feed : A Systematic Literature Review
Authors: Islami Romi Zamhir , Utomo Dhanan , Budiawati Yeni
Published: February 2025

This systematic literature review aims to explore existing research on the identification and analysis of various agricultural by-products and waste. The novelty of this article lies in its systematic approach to examining the potential and utilization of agricultural waste and by-products as ruminant animal feed. The research employed the PRISMA flowchart methodology, utilizing three databases: Scopus, EBSCO, and PubMed. EndNote X9 version is used to analyze, 283 articles were initially collected, of which 233 met the inclusion criteria based on title and content, covering studies published from 1976 to 2024. Findings reveal that a significant portion of agricultural by-products originates from plantations and horticulture, with poultry, particularly broiler chickens, being the dominant subject of study. The primary research focus has been on poultry, particularly broiler chickens, and ruminant livestock. The findings highlight that research on livestock feed derived from agro-industrial and agricultural waste has significantly contributed to improving livestock performance, such as weight gain and feed efficiency. This review underscores the need for further innovative research integrating agricultural waste utilization with approaches such as probiotics and fermentation. It also calls for greater emphasis on livestock health parameters as primary indicators. Such advancements are expected to support the sustainability of the livestock sector and address global challenges related to animal welfare.
De-torsion without oophoropexy for torsion of normal ovary in children: a report of 10 cases
Authors: Duan Fei , Niu Huizhong
Published: February 2025

Study objective Torsion of normal ovary is rare in children. There is no consensus on the optimal method. A preliminary study of the clinical features of normal ovarian torsion and the efficacy and feasibility of de-torsion without oophoropexy in children.
Design Retrospective analysis of the clinical data of 10 girls with normal ovarian torsion treated in the Department of General Surgery,Hebei Provincial Children's Hospital from May 2018 to December 2023.According to whether the ovaries have atrophied and disappeared during follow-up,they were categorized into atrophy group(4 cases) and non-atrophy group(5 cases).The age,affected side, nausea and vomiting,fever,onset-operation time,degree of torsion,color of ovary,preoperative and postoperative neutrophil(NE),C-reaction protein(CRP) and white blood cell(WBC) were compared between the two groups.The surgical procedure was laparoscopic de-torsion without oophoropexy.Hematoma removal in 5 cases of severely congested ovaries.Follow up the children for recurrent torsion and recovery of ovarian function.
Participants Childrenwith a diagnosis of normal ovarian torsion intraoperatively confirmed and surgically treated in our department.
Results There was statistical differences in onset-operation time, color of ovary,preoperative CRP and nausea and vomiting(P<0.05).No statistical difference was found in age,affected side,fever,torsion degree, preoperative WBC and NE,postoperative WBC,NE and CRP(P>0.05). No recurrent torsion after laparoscopic de-torsion without oophoropexy.Normal ovarian morphology and functional recovery in the non-atrophy group.
Conclusions High incidence of atrophy after de-torsion of normal ovarian torsion in children.There was no recurrent torsion without oophoropexy.Children with longer onset, darker ovaries and higher preoperative CRP are more likely to develop ovarian atrophy postoperatively, but those with nausea and vomiting are less likely to develop ovarian atrophy.
Exploring Donor Attitudes and Psychological Experiences in Anonymous and Identity-Release Oocyte Donation: A Systematic Review
Authors: Pote Vibha , Figueiredo Dwight
Published: February 2025

Background
Despite being a commonly recognized method of assisted reproduction, oocyte donation presents questions regarding the attitudes, psychological experiences, motivations, and ethical dilemmas of donors. The intricacies of identity release and anonymous systems are examined in this review, with particular attention paid to relationship expectations, counselling requirements, and legal frameworks.
Methods
Donor perspectives, motivations, emotional health, and ethical implications were examined through a systematic evaluation of 23 studies. Analysis was conducted on themes such as counselling needs, boundary setting, and emotional fulfilment.
Results
Most identity-release donors were in favour of openness, with 65–95% of them being prepared to reveal their identities for ethical and developmental reasons. However, some voiced concerns about emotional difficulties and role uncertainty. Although 70–80% of anonymous donors valued privacy, 15–20% later expressed interest and sorrow over missed opportunities for interaction. While financial incentives were more important for anonymous contributors (40–50%), altruism was the primary driver for 85–95% of the identity-release donors and 70–80% of the anonymous donors. Post-donation satisfaction was high (85–99%) despite pre-donation hesitation (20–25%). Legal frameworks have improved preparedness and satisfaction, such as identity-release regulations in Finland and Sweden. Counselling requirements varied: anonymous donors needed post-donation assistance, whereas identity-release donors needed pre-donation counselling.
Conclusion
Transparency methods increase donor readiness and satisfaction, whereas anonymous systems preserve privacy, but cause psychological difficulties. Supporting the well-being of donors and their progeny requires improved counselling and legal protection.
Cost‒Benefit Analysis of Aquaponic and Hydroponic Systems in Barley Production: A Sustainable Agriculture Approach
Authors: Owdeh Angham Bani , Salman Muayad , Romdhane Mohamed Salah
Published: February 2025

The primary objective of this study was to perform a comprehensive cost‒benefit analysis of barley production within both aquaponic and hydroponic systems. This research undertakes a detailed cost‒benefit evaluation comparing aquaponic and hydroponic methods for barley cultivation, with a focus on their economic viability and sustainability. A local variety of barley was selected to analyze the production outcomes and operational costs associated with each cultivation technique. The key metrics evaluated included tray net weight, dry matter percentage, and crude protein yield, which were measured on the 7th and 14th days posts eeding. The results indicated that by the 14th day of cultivation, the aquaponic system presented the highest net weight of the trays (11.80 kilograms), whereas the hydroponic system without nutritive solution yielded a net weight of 9.27 kilograms, and the nutrient solution resulted in a net weight of 9.58 kilograms. The dry matter percentage was 17% for the aquaponic system and 14% for both hydroponic treatments. The total crude protein output per tray was significantly greater in the aquaponic system, reaching 387.44 grams, whereas the barley hydroponic system with nutrient mixture produced 332.15 grams, and the hydroponic system without nutritive mixture yielded 227.18 grams at the 14-day mark. Notably, substantial profits were observed, with the aquaponic system generating the highest net revenue. These findings underscore the economic advantages of aquaponics by effectively integrating fish cultivation with plant production, establishing it as a viable method for enhancing food security and sustainability, particularly in resource-constrained settings.
Untargeted Lipidomics Profiling Provides Novel Insights into Pediatric Patients with Sepsis: An Exploratory Study
Authors: Awuti Reyihangu , Bai Jiayi , Cheng Ye , Yang Weili , Cheng Zimei , Zhou Hetian , Su Guoyun , Wang Kexin , Wang Yaodong , Liu Tingyan , Liu Ying , Chen Weiming , Chen Hehe , Lu Guoping , Zhang Caiyan
Published: February 2025

Introduction
The plasma lipidome has emerged as an important indicator for assessing host metabolic and immune status in sepsis. While previous studies have largely examined specific lipid class changes in adults sepsis, comprehensive investigations into plasma lipidomic alterations in pediatric sepsis are limited. This study aimed to characterize the plasma lipidome in pediatric sepsis using a metabolomics-based exploratory approach, providing insights into pathophysiological mechanisms and potential biomarkers.
Methods
A retrospective study was conducted on pediatric patients with sepsis admitted to the pediatric intensive care unit (PICU). Untargeted lipidomics analysis using ultra-performance liquid chromatography coupled with Orbitrap mass spectrometry (UPLC-Orbitrap) was performed to compare metabolomic profiles between non-infected control patients and sepsis patients.
Results
Compared to controls, plasma lipid levels in sepsis patients decreased by 33.3%, increased by 20.2%, and remained unchanged in 46.5% of cases. Several lipid molecules were identified to be associated with disease severity and inflammatory markers. In the recovery and deterioration subgroups, 186 differential lipid molecules were identified, with triglycerides (TG) being the most abundant class. Notably, 15 lipid molecules overlapped between those associated with disease severity and those linked to clinical outcomes. Fatty acid (FA) levels were significantly elevated in the sepsis group compared to controls, with arachidonic acid (FA(20:4)) showing the most significant increase (P < 0.001).
Conclusion
Alterations in plasma lipid profiles among children with sepsis reflect disease severity, systemic inflammatory responses, and clinical outcomes. These findings underscore the prognostic potential of lipidomics and its value in understanding sepsis pathophysiology.
The Effect of Supply and Demand on Sugar Production Indonesia
Authors: Rizal
Published: February 2025

Sugar is a vital commodity in Indonesia, serving as a staple ingredient in households and industries. The interplay of supply and demand significantly impacts sugar production, influencing prices, farmer incomes, and national food security. Comprehending these factors assists policymakers and stakeholders in devising strategies for a stable and sustainable sugar industry. Sugar is a staple foods that plays an important role in the Indonesian economy because Indonesia is one of the countries that produces granulated sugar, but still imports it every year. among the staple food that holds a significant role in the Indonesian economy since Indonesia is one of the countries that produce granulated sugar but still import it annually. This study aims to: (1) determine the demand trend for granulated sugar in Indonesia, (2) ascertain the supply trend of granulated sugar in Indonesia, (3) identify the gap between supply and demand trends for granulated sugar in Indonesia, (4) analyze the factors influencing demand for granulated sugar in Indonesia, and (5) examine the factors affecting the supply of granulated sugar in Indonesia. This study employs descriptive methods, cause and effect analysis, and a quantitative approach utilizing secondary data. The study was intentionally conducted in Indonesia, considering that Indonesia is among the countries that produce granulated sugar but still import it annually. The data utilized is secondary data sourced from various channels. The analysis methods employed include trend analysis and multiple analyses of the Cobb-Douglas model. The results of the study concluded that: (1) the trend of demand for granulated sugar in Indonesia is increasing, (2) the trend of supply of granulated sugar in Indonesia is increasing, (3) the trend of the gap between supply and demand for granulated sugar in Indonesia is increasing, (4) factors that significantly influence the demand for granulated sugar in Indonesia are the price of granulated sugar, the price of tea, the price of ground coffee, while factors that do not significantly influence are the price of brown sugar, population, per capita income. (5) Factors that significantly influence the supply of granulated sugar in Indonesia are the farmer's benchmark price, the price of granulated sugar, and the price of SP-36 fertilizer.
Зарождение англо-русских отношенийи дипломатия Швеции в середине XVI века
Authors: Киселев А.А.
Published: February 2025

Статья посвящена внешней политике шведского короля Густава Вазы, которая была направлена на разрушение англо-русской торговли в середине XVI в. В своем стремлении сделать Швецию независимой балтийской державой король Густав I играл на противоречиях стран Западной Европы, Ганзейского союза и Московского государства. Однако установление прямой англо-русской торговли в 1553 году нарушило существующий баланс сил на Балтике и подтолкнуло Швецию к войне с Россией. Неудачная внешняя политика Швеции в конце правления Густава I заставила его наследников сосредоточиться на борьбе за Прибалтику.

The article is devoted to the foreign policy of the Swedish king Gustav I Vasa that was focused on the destruction of the Anglo-Russian trade in the middle of the sixteenth century. In his effort to make Sweden an independent Baltic power, king Gustav I played on the contradictions of the countries of Western Europe, the Hanseatic League and the Muscovy State. However, the establishment of direct Anglo-Russian trade in 1553 broke the existing balance of power in the Baltic and pushed Sweden to a war with Russia. Unsuccessful foreign policy of Sweden in the end of the reign of Gustav I forced his heirs to concentrate on the struggle for the Baltic.
Программные установки Британского союза фашистовв отношении Англиканской церкви
Authors: Арджаванидзе А.С.
Published: February 2025

В статье дается обзор положений программных документов Британского союза фашистов (БСФ), касающихся отношений английских фашистов к Англиканской церкви. Также в статье рассматривается позиция англиканского духовенства в отношении БСФ.

The article provides an overview of the provisions of the program documents of the British Union of Fascists (BUF), the relations of the British fascists with the Anglican Church are conducted. The article also indicates the position of the Anglican clergy in relation to the BUF.
«Обратить фашистский слёт в триумф антифашистских сил»: демонстрация 9 сентября 1934 года в Англии
Authors: Рудая О.И.
Published: February 2025

Статья посвящена рассмотрению борьбы английской общественности против Британского союза фашистов во главе с Освальдом Мосли в 1933–1934 гг. Особое внимание уделяется характеристике «контрдемонстрации» 9 сентября в лондонском Гайд-парке, ставшей крупнейшей акцией протеста против политики чернорубашечников в 1934 г.

The article deals with the struggle of the British public against the British Union of Fascists led by Oswald Mosley in 1933–1934. Special attention is paid to the characteristic of the “counter-demonstration” on September 9 in London's Hyde Park, which became the largest protest against the Blackshirts ' policy in 1934.
Nanoscale mapping of ZrSiO4 phases in naturally-shocked zircon using electron energy loss spectroscopy
Authors: Roddatis Vladimir , Kovaleva Elizaveta , Syczewski Marcin D. , Schreiber Anja , Wirth Richard
Published: February 2025

Coexistence in natural samples of zircon (ZrSiO4) and reidite (high-pressure polymorph of ZrSiO4) is attributed to the effect of hypervelocity impact events. The grains and intergrowths in those minerals can be merely a few nanometers in size, which makes phase identification by standard methods of structure analysis difficult. However, analytical scanning transmission electron microscopy (STEM) utilizing electron energy-loss spectroscopy (EELS) can provide important information on phase transition mechanisms and pressure-temperature conditions of the associated shock event at the nanoscale. Here we demonstrate that the valence as well as oxygen core-loss EELS can be employed for nanoscale mapping of zircon-reidite distributions in zircon-reidite aggregates. Moreover, other accompanying phases, e.g., baddeleyite, could also be identified and mapped by this method. We further compare the EELS maps with a 4D-STEM nanobeam precession electron diffraction data, and demonstrate the advantages of the EELS mapping, which provides spatial resolution down to the nanometer scale and is independent on crystal orientation.
Sublattice Disorder and Fe-Mg Substitution in Brucite: Implication for the Subduction-Zone Water Cycle
Authors: Gui Weibin , Liu Jin , Deng Ao , Hu Jun , Sun Penghui , Fan Changzeng , Xiong Fahui
Published: February 2025

This study investigates the vibrational properties of hydroxyl groups in pure and Fe-bearing brucite under high pressure and temperature conditions relevant to subduction zones. Using externally-heated diamond-anvil cell techniques combined with in-situ laser Raman spectroscopy, we observed that the hydroxyl stretching modes in pure brucite change from blueshift to redshift at approximately 600 K and 1.2 GPa. This indicates a sublattice proton order-disorder transition associated with decreasing interlayer spacing in brucite. Moreover, the Fe-Mg substitution in brucite leads to a secondary hydroxyl stretching band at 3644.6 cm−1 for Mg0.9Fe0.1(OH)2 while the primary Raman band is changed to 3636.7 cm−1. This new Raman mode persists with increasing temperature at atmospheric pressure, but disappears at about 3.0 GPa. The decomposition temperature of this Fe-bearing brucite sample is about 130 K lower compared to pure brucite under high oxygen fugacity conditions. These results suggest that the sublattice transition and Fe-Mg substitution may influence the stability of brucite, providing insight into the deep-water cycle at shallow subduction zones.
Snowball Quartz in Highly Fractionated Peraluminous Granites: An Indicator of Multiple Magma Degassing
Authors: Zhang Daohan , Qiu Kunfeng , Xu Chang , Luan Yuwei , Li Yanjun , Wei Junhao , Deng Jun
Published: February 2025

Snowball quartz is commonly found in highly fractionated peraluminous granites that may be associated with mineralization of Ta, Nb, Li, W, Sn, and Rb. The genesis of snowball quartz has been a subject of controversy, and its genetic relationship with potential rare metal mineralization remains poorly understood. This paper presents a study of the mineralogy and chemistry of quartz and plagioclase from the Yashan pluton in southern China. The Yashan pluton hosts the Yichun Ta-Nb-Li deposit and is primarily composed of two-mica granite, Li-mica granite, and topaz-lepidolite granite, which were intruded by granite dikes. The texture known as “snowball” is observed in quartz from Li-mica granite, but it is more frequently and prominently developed in quartz from topaz-lepidolite granite and granite dikes. This texture is characterized by the zonal arrangement of prismatic albite (referred to as snowball albite) within quartz phenocrysts, with the {010} face of snowball albite preferentially adhering to the crystal faces of quartz. It typically develops in specific domains of the mantle and/or rim of quartz phenocrysts, and occasionally in their cores. The snowball texture is preferentially developed on the prism faces (m) of quartz, as indicated by a higher abundance of snowball albites on these faces compared to others. The snowball-textured quartz domain (SBTQD) is texturally similar to other domains from the same growth zone and chemically overlaps with magmatic quartz cores or rims. The snowball albites are chemically indistinguishable from magmatic albite inclusions entrapped within quartz cores. These pieces of evidence suggest that the SBTQDs have a magmatic origin. Given the specific morphologies of snowball quartz (well development of prism faces) and albite (prismatic with a high aspect ratio of ∼5–10), along with the development of sector zoning in quartz, it is proposed that the snowball quartz formed as a result of rapid growth of quartz and albite under moderate undercooling (ΔT = 50–100 °C) at near-solidus conditions, which was associated with multiple episodes of magma degassing. From the perspective of Ta-Nb mineralization, this degree of undercooling would significantly reduce the solubility of tantalite by more than 70-90 %, thereby facilitating its crystallization. This process also promotes the further crystallization of already saturated columbite. Therefore, snowball quartz could serve as an exploration indicator for Ta-Nb deposits associated with highly fractionated peraluminous granites.
Acurácia da escala Bedside Pews para determinação do agravamento clínico na admissão de pacientes pediátricos
Authors: Peres Merianny de Avila , Silveira Marina Scherer , Vieira Letícia Becker , Silva Thiago , Breigeiron Márcia Koja , Wegner Wiliam
Published: February 2025

Objetivo: Avaliar a acurácia da Bedside PEWS para determinação do agravamento clínico de pacientes pediátricos durante a admissão. Método: Estudo transversal e retrospectivo. Amostra de 591 prontuários de crianças admitidas em emergência pediátrica, entre janeiro e dezembro de 2018. Dados analisados por estatística descritiva e inferencial. Para cada ponto de corte da Bedside PEWS foram estimados sensibilidade e especificidade, tomando-se como desfecho a transferência para terapia intensiva, e uma curva receiver operating characteristic (ROC) foi construída com estes valores. Resultados: Na admissão na emergência, para PEWS>4, a acurácia da curva ROC foi 76,9%, sensibilidade 59,1% e especificidade 78,0% (p<0,001). Na transferência da emergência, para PEWS>5, a acurácia da curva ROC foi 87,4%, com sensibilidade 72,6% e especificidade 94,3% (p<0,001). Conclusões: A Bedside PEWS é uma ferramenta válida na avaliação de agravamento clínico em crianças, tendo como melhor indicador PEWS≥5.
¿Definir al político pensando en el dialéctico? Notas acerca de las capacidades de los paradeígmata en el Político de Platón
Authors: Álvarez Lucas
Published: February 2025

In the framework of the discussion about the potential identification of the statesman with the philosopher in the post-Republic Platonic dialogues, this paper focuses on the approach proposed in Statesman. Specifically, it focuses on the use of a methodological resource, parádeigma, to which the interlocutors appeal to define the statesman. In this sense, we contribute to the discussion by identifying a series of contact points that unite the characterization of the statesman with that of the philosopher-dialectician that emerges in Plato’s late works.
Municipal Solid Waste Landfill Site Selection: Integrating Multi-Criteria Decision-Making Methods and Mathematical Modelling - A Case Study
Authors: Derse Onur , Göçmen Polat Elifcan
Published: February 2025

Increasing solid waste amount arisen from the urbanization and population growth is an inevitable outcome in many countries. Solid waste has become one of the serious environmental problems and peculiar solid waste pathways are required to prevent contamination of environment. The optimal planning of the waste management should comprise the operations such as minimization, collection, landfilling and recycling of the waste. Also, location selection for landfill of municipal solid waste (MSW) is an effective step even essential, due to growing area shortage for waste disposal. In this respect, landfilling of MSW has been addressed in Tunceli, Turkey using an integrated approach. The Fuzzy Analytical Hierarchy Process (Fuzzy-AHP), a multi-criteria decision-making (MCDM) method, is utilized to decide the weights of the environmental, technical, economic, and social criteria regarding uncertainty. Then, the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) is conducted to rank the alternative landfill districts. Finally, the sub locations of selected district are mathematical modelled regarding transport cost, investment cost and demand with an integer linear programming model. The computational results indicate the proposed method effectiveness with a systematic approach by integrating MCDM and mathematical modelling.
SAHRAN: Sentiment Analysis of Hotel Reviews with Attention-Based Recurrent Neural Network
Authors: Çetiner Halit , Metlek Sedat
Published: February 2025

Automatically analysing the sentiment of comments expressed by a user on a web page for any purpose is a rapidly expanding important research area. Text sentiment analysis, as it is known in the literature, is a technique that allows users to determine their emotional tendencies in comments defined for any purpose. Users comment on the content of web pages used by thousands of people such as vacation sites, shopping pages, social media, brand reviews, financial reviews, health sites, political pages. The comments made have the ability to directly affect a user who wants to benefit from these services in any way. For these reasons, it is important to examine people's emotions in their comments in automatic review of comments. Recurrent Neural Network (RNN) based architectures have achieved remarkable success in solving Natural Language Processing (NLP) problems. In this article, an RNN based deep learning model is proposed that works on a publicly available dataset obtained from the TripAdvisor web page and performs sentiment analysis. The proposed SAHRAN model uses an attention mechanism based on the dot product structure to capture emotional words in user comments. In the model, Bidirectional Gated Recurrent Unit (BiGRU) and Bidirectional Long Short Term Memory (BiLSTM) deep learning layers are integrated into the model to capture emotional features. As a result of the experimental studies, the proposed SAHRAN model achieved performance values of 0.9524, 0.9685, 0.9082 and 0.9338 in terms of precision, recall, F1 score and accuracy performance measures, respectively.
Biotechnological Potential of Rheinheimera sp. L-asparaginase: Heterologous Production and Its Role in Acrylamide Mitigation
Authors: Tülek Ahmet
Published: February 2025

Acrylamide, a chemical contaminant found in foods, poses a significant health threat because of its toxic and carcinogenic properties. One of the most effective methods for reducing acrylamide is the application of L-asparaginase (L-ASNase) to decrease the asparagine content in foods before cooking or processing. In this study, L-ASNase (RsASNase) from Rheinheimera sp. was expressed heterologously in Escherichia coli Rosetta™2 (DE3) host cells. The enzyme was purified using Ni2+-NTA affinity chromatography, yielding a specific activity of 392.2 U/mg and a purification fold of 4.0. Acrylamide reduction was assessed using a starch-L-asparagine model analyzed by high-performance liquid chromatography (HPLC). The highest acrylamide mitigation (52.3%) was achieved using 100 U of the enzyme after 120 min of incubation. Additionally, the three-dimensional structure of RsASNase was modeled using the ProMod3. Bioinformatics analyses, including docking studies, revealed interactions between the RsASNase enzyme's active site and the L-asparagine substrate, involving the amino acids THR162A, LYS242A, THR273A, LEU304A, and GLU305A. These findings showed that RsASNase has the potential for further development and application in biotechnological processes aimed at acrylamide mitigation.