bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilization of HCV Viremic Kidneys with Genotyping/Subtyping‐Free Sofosbuvir/Velpatasvir Treatment Strategy: Experience from China
Authors: Zhang Hedong , Liu Qiuhao , Hu Shanbiao , Zhong Mingda , Peng Fenghua , Guo Yong , Fang Chunhua , Nie Manhua , Tan Liang , Dai Helong , Xie Xubiao , Peng Longkai , Lan Gongbin
Published: July 2022

Background. Owing to the advent of pangenotypic direct‐acting antiviral agents (DAAs) for hepatitis C virus (HCV) treatment, utilization of HCV‐infected deceased donor kidneys with simplified genotyping/subtyping‐free sofosbuvir/velpatasvir (SOF/VEL) treatment strategy is now becoming a promising strategy for expanding the organ donor pool. Methods. This retrospective, comparative, single‐center study included HCV viremic donor kidneys that were transplanted to 9 HCV‐positive (HCV Ab‐positive) recipients (D+/R+ group) and 14 HCV‐negative recipients (D+/R‐ group) from May 2018 to January 2021. Both groups received prophylaxis with SOF/VEL treatment within 1‐week posttransplant devoid of HCV genotyping/subtyping. The primary outcomes were sustained virologic response 12 weeks after completion of therapy (SVR12) and graft survival at 1‐year posttransplant. Results. Baseline characteristics were similar between the HCV D+/R‐ and D+/R+ groups. The mean age of all recipients was 39.09 ± 9.65 (SD) years, and 73.9% were male. A total of 92.9% (13 out of 14) recipients had pretreatment HCV viremia in the D+/R‐ group. The pretreatment HCV viral load in the D+/R+ group (5.98, log 10 IU/mL; IQR, 5.28‐6.53) was significantly higher than that in the D+/R‐ group (3.61, log 10 IU/mL; IQR, 2.57‐4.57). After SOF/VEL treatment, SVR12 was achieved in all recipients, with a 100% 1‐year patient and graft survival rates. The D+/R+ group had a higher incidence of abnormal liver function (44.4% vs. 7.1%). No significant difference was observed between the two groups in terms of DGF, acute rejection, ALT, serum creatinine, and eGFR within 1‐year posttransplant. No severe adverse events associated with either HCV viremia or SOF/VEL were observed. Conclusions. Using a simplified genotyping/subtyping‐free SOF/VEL treatment strategy, kidneys from hepatitis C viremic donors for both infected and uninfected recipients presented with safe, excellent, and comparable 1‐year outcomes, which can safely expand the donor pool. HCV‐positive donor kidneys should be utilized regularly, regardless of the recipient’s HCV status.
BA-GCA Net: Boundary-Aware Grid Contextual Attention Net in Osteosarcoma MRI Image Segmentation
Authors: Wu Jia , Liu Zikang , Gou Fangfang , Zhu Jun , Tang Haoyu , Zhou Xian , Xiong Wangping
Published: July 2022

Osteosarcoma is one of the most common bone tumors that occurs in adolescents. Doctors often use magnetic resonance imaging (MRI) through biosensors to diagnose and predict osteosarcoma. However, a number of osteosarcoma MRI images have the problem of the tumor shape boundary being vague, complex, or irregular, which causes doctors to encounter difficulties in diagnosis and also makes some deep learning methods lose segmentation details as well as fail to locate the region of the osteosarcoma. In this article, we propose a novel boundary-aware grid contextual attention net (BA-GCA Net) to solve the problem of insufficient accuracy in osteosarcoma MRI image segmentation. First, a novel grid contextual attention (GCA) is designed to better capture the texture details of the tumor area. Then the statistical texture learning block (STLB) and the spatial transformer block (STB) are integrated into the network to improve its ability to extract statistical texture features and locate tumor areas. Over 80,000 MRI images of osteosarcoma from the Second Xiangya Hospital are adopted as a dataset for training, testing, and ablation studies. Results show that our proposed method achieves higher segmentation accuracy than existing methods with only a slight increase in the number of parameters and computational complexity.
Correlation Analysis between Financial Development Level and City Size Based on Mutual Information Algorithm
Authors: Kong Yi
Published: July 2022

Urbanization is the accompaniment of industrialization and modernization, a symbol of the progress of human civilization, and it has always been the focus of social attention. With the transfer of rural population to cities, the secondary and tertiary industries continue to produce agglomeration effects, and the urbanization process is accelerated. The level of urbanization has gradually become an important indicator to measure the degree of regional development, which has led to the exploration of the inner dynamics of urbanization. Finance is the core of modern economy, and urbanization is an important driving force for modern economic and social development. Research on the relationship between financial development and urban scale should also receive widespread attention. On the basis of reviewing and sorting out the related research results of urbanization and financial development, this paper makes an in-depth analysis of urbanization and financial development, respectively, aiming to have a systematic, comprehensive, and objective analysis of the interaction between urbanization and financial development. On this basis, combined with the current situation of our country’s financial development and urbanization, the internal relationship between the two is discussed. Based on the mutual information algorithm, this paper selects indicators that are representative of urbanization level, financial development, and economic development. By using the mutual information theory to analyze and rank the social and economic factors related to financial factors, it reveals the most relevant and accurate financial forecast. Then, it also discusses whether there is a cointegration relationship between urbanization and financial development and economic growth in our country and the causal relationship between them and analyzes the reasons on this basis.
[Retracted] A Preliminary Study on the Dramatic Factors of Ancient Chinese Poetry under the Changing Geographical Environment
Authors: Liu Yanfang
Published: July 2022

The formation of Chinese traditional culture is influenced by many factors, and the natural geographical environment is an important factor. Because a country’s status is based on its geographical environment, it affects many aspects, such as economic composition and national psychology. As one of the expression forms of traditional Chinese culture, ancient Chinese poetry has a great influence on the emergence and development of Chinese traditional culture. Therefore, this paper mainly discusses the specific influencing factors of the drama of the ancient Chinese poetry, and the preliminary study of it is of certain significance to the development of Chinese traditional culture.
The Relation between Immunological Features and the Positive SARS-CoV-2 Nucleic Acid in Patients with Nonsevere COVID⁃19
Authors: Zhang Dong , Li Xueren , Sun Haibai , Shi Lixia , Peng Shouchun
Published: July 2022

Objective. The novel coronavirus nucleic acid results are the core indicators of illness monitoring. This study aimed to evaluate the relationship between immunological features and positive SARS-CoV-2 nucleic acid by analyzing the clinical and immunological features in nonsevere COVID-19 cases. Methods. Data from nonsevere COVID-19 patients admitted to Haihe Hospital from May 2020 to June 2021 were retrospectively reviewed and analyzed. Results. (1) A total of 122 cases were reviewed in the present study, including 38 mild and 84 moderate cases. The average age of mild cases was significantly different from moderate cases (

P
<
0.001

). Eight patients complained of hyposmia and it was more frequent in mild cases (

P
<
0.001

). The nucleic acid positive duration (NPD) of nonsevere novel coronavirus was 20.49 (confidence interval (CI) 17.50–3.49) days. (2) The levels of specific IgM and IgG for COVID-19 were higher in mild cases than in moderate cases (

P
=
0.023

and

P
=
0.047

, respectively). (3) The correlation analysis with antibodies and T-cell subtypes showed that the lymphocyte (LYM) count, T cells, CD4+T cells, and CD8+T cells had a linear correlation with NPD. (4) Among the 93 patients monitored, 62 COVID-19 cases presented a progressive rise of specific IgM and IgG. The daily increase rates of IgM and IgG were 38.42% (CI 28.22–48.61%) and 24.90% (CI 0.23–29.58%), respectively. Conclusion. The levels and daily increase rates of specific IgM and IgG against the virus can vary between cases. The NPD presented a linear correlation with the LYM, T cells, CD4+T cells, and CD8+T cells. Hence, more attention should be paid to these indicators in clinical practice.
Characterization of Waste Generated from Nuclide Management Process in Waste Burden Minimization Technology for Spent Nuclear Fuel
Authors: Choi Jung-Hoon , Lee Byeonggwan , Lee Ki-Rak , Kang Hyun Woo , Eom Hyeon Jin , Shin Seong-Sik , Kim Ga-Yeong , Park Hwan-Seo
Published: July 2022

To reduce the environmental burden caused by the disposal of spent nuclear fuel, waste burden minimization technology is currently being developed at the Korea Atomic Energy Research Institute. The technology includes a nuclide management process that can maximize disposal efficiency by selectively separating and collecting major nuclides in spent nuclear fuel. To manufacture a waste form of high durability, the characteristics of the waste generated during the process should be evaluated. In this study, the physical, radiological, and thermal characteristics of the waste and waste forms for major nuclides (Cs, Sr, I, transuranic/rare earth, and Tc/Se) generated in the nuclide management process were analyzed. In the case of Cs nuclides, characterization was conducted according to the capture rate of the adsorbent in the high-temperature heat treatment process; meanwhile, in the case of Sr nuclides, characterization was performed by considering the ratio of similar nuclides in the chlorination process. For I nuclide, analysis was performed based on the available waste form, and for TRU/RE and Tc/Se nuclides, analysis was performed by considering chlorination and mid-temperature heat treatment. The radioactivity and heat generation rate of each waste and waste form were evaluated over a period of 1,000 years. The results of this study could be used to derive the centerline temperature for the thermal stability evaluation of waste forms and for the feasibility evaluation of each disposal system considered in the waste burden minimization technology.
Design for Bedridden Elderly: Presenting Pressure Ulcer Product Design Based on Anthropometric Characteristics
Authors: Zhou Jie , Li Wanqiang , Hu Hong
Published: July 2022

Pressure ulcers are a type of injury that causes tissue ischemia, a deficiency of nutrition and oxygen to the tissues, and, eventually, tissue necrosis when an area of skin is placed under constant pressure for an extended length of time. With the acceleration of the aging process, the problem of providing care for pressure ulcers for the bedridden elderly becomes increasingly urgent. This study conducts a field survey based on the research status of 221 disabled elderly in 16 communities on 7 typical streets in Beijing, focusing on the problem of pressure ulcer complications caused by bedridden. An automatic inflatable airbag mattress is designed according to anthropometric dimensions of bedridden elderly, pressure ulcer-prone areas, and the decompression standard, so that the airbag mattress can reduce the pressure in its initial shape. To achieve accurate control of the pressure in the pressure-prone areas of an airbag, air pressure control system is proposed which can control airbags individually and link multiple airbags, evaluating the safety of pressure ulcer points based on the data from sensors and making corresponding air pressure changes to reduce the possibility of generating pressure ulcers. The proposed pressure ulcer preventing system will be an efficient healthcare tool for families who had elderly bedridden patients, patients with chronic degenerative disease side effects, and terminal and postsurgical patients, as well as femur fractures, in their homes.
Meta-Analysis of the Efficacy and Safety of Chlorhexidine for Ventilator-Associated Pneumonia Prevention in Mechanically Ventilated Patients
Authors: Dai Weiying , Lin Yao , Yang Xiangying , Huang Pei , Xia Liuqin , Ma Jianping
Published: July 2022

Objective. To explore the efficacy and safety of chlorhexidine oral care in the prevention of ventilator-associated pneumonia (VAP) by means of meta-analysis. Methods. Randomized controlled trials on the effect of chlorhexidine oral care on the incidence of VAP in patients on mechanical ventilation were searched in PubMed, Scopus, Cochrane Library, and Embase from May 1, 2022. Two researchers independently screened and included the study, extracted the data, and evaluated the literature quality. RevMan5.3 software was used for meta-analysis. Results. Meta-analysis of 13 included literature studies involving 1533 patients showed that oral care with chlorhexidine solution could reduce the incidence of VAP in patients with mechanical ventilation and the difference was statistically significant (RR = 0.61, 95% CI (0.46, 0.82),P=0.04). However, the results showed that the incidence of VAP of low concentration (0.02%, 0.12%, and 0.2%) and high concentration (2%) of chlorhexidine in the intervention group was lower than that in the control group and the difference was statistically significant (RR = 0.70, 95% CI (0.51, 0.96),P=0.03; RR = 0.41, 95% CI (0.27, 0.62)). There was no significant difference in mortality between the two groups (RR = 1.01, 95% CI (0.85, 1.21),P=0.87). There was no statistical significance in days ventilated or days in ICU between the two groups (RR = −0.02, 95% CI (−0.19, 0.16),P=0.84; RR = 0.01, 95% CI (−0.11, 0.14),P=0.85). Conclusion. Existing evidence shows that chlorhexidine used for oral care of patients with mechanical ventilation can reduce the incidence of VAP, and high concentration of chlorhexidine (2%) or low concentration of chlorhexidine (0.02%, 0.12%, 0.2%) has a significant effect on the prevention of VAP. Considering the safety of clinical application, it is recommended to use 0.02%, 0.12%, and 0.2% chlorhexidine solution for oral care.
Analysis of Physical Fitness Evaluation System for Weightlifters Based on Analytic Hierarchy Process
Authors: Hu Juanjuan , Zulkapri Izwyn Binti
Published: July 2022

As China has repeatedly achieved excellent results in world-class sports events, the country attaches great importance to sports training, among which weightlifting is an advantageous sports event in China. Physical fitness is also the main sports ability to evaluate the function of weightlifters, which has a direct impact on their competitive ability in sports competition. However, there are some problems in evaluating the physical fitness of weightlifters, such as unclear indicators and unclear weight. Therefore, this paper establishes the physical fitness evaluation system of weightlifters based on the analytic hierarchy process and evaluates the physical fitness of weightlifters from three aspects: body shape, body function, and sports quality. In addition, it briefly introduces the calculation process of the analytic hierarchy process, analyzes the constituent factors of weightlifters’ physical fitness, defines the indexes of weightlifters’ physical fitness evaluation system, and calculates the weight of each index. This study performed many experiments by selecting 10 weightlifters to substitute the relevant data into the evaluation index system and analyzed the body shape of weightlifters. In addition, the results showed that the highest blood testosterone was 926.7 ud/dl, with a score of 95 points, and the lowest was 690.3 ud/dl, with a score of 65 points. The results also show that the highest high snatch with score 95 is 123 kg and the lowest high snatch with score 60 is 98 kg. According to the above research results, the overall physical fitness of Chinese weightlifters is high.
Urban Green Space Planning and Design for Sponge City
Authors: Jiao Hong , Han Jingliang
Published: July 2022

Urban green space designed based on the concept of sponge city is an important sponge carrier. Guided by the theory of landscape ecology, this article introduces the artificial neural network (ANN) model and uses the research method of landscape pattern index to establish a model for the proportion of urban green space types and the characteristics and dynamic changes of landscape spatial pattern. Based on the optimal landscape pattern index, the theoretical value of the optimal proportion of ecological green space, community park, comprehensive park, roadside green space, protective green space, and strip green space is obtained through the model. Based on this proportion value, combined with the ANN model, the reasonable evaluation results of patch density and average perimeter area ratio, spread degree, and diversity index of planned green space are obtained. Then, according to the influence of various green spaces on each landscape index, the development trend of urban green space construction in the future is predicted.
Effect of Paclitaxel Combined with Doxorubicin Hydrochloride Liposome Injection in the Treatment of Osteosarcoma and MRI Changes before and after Treatment
Authors: Tian Ning , Wang Dongmei , Li Xiaobao , Xue Minghua , Zheng Bo
Published: July 2022

Objective. The aim of this study is to investigate the effect of paclitaxel combined with doxorubicin hydrochloride liposome injection (DHLI) in the treatment of osteosarcoma and the MRI changes before and after treatment. Methods. A total of 108 osteosarcoma patients treated in our hospital (January 2020–April 2022) were selected to carry out a single-center retrospective study. Among them, 54 patients receiving the combination chemotherapy (MDT) with high-dose methotrexate, ifosfamide, cisplatin, and ADM were selected as the control group (COG), while 54 patients receiving MDT with high-dose methotrexate, ifosfamide, cisplatin, paclitaxel, and DHLI were chosen as the study group (STG). The COG and STG had the same dose intensity and chemotherapy cycles, and clinical and MRI evaluations were performed after treatment. Results. The evaluation of postoperative clinical efficacy showed that the disease control rate (DCR) of the STG was markedly higher than that of the COG (

P
<
0.05

). The incidence of cardiac toxicity was remarkably lower in the STG than that in the COG (

P
<
0.05

), with no between-group differences in the incidence of fever, abnormal liver function, myelosuppression, stomatitis, and alopecia (

P
>
0.05

). Obvious differences were found in the semiquantitative parameters of MRI in the STG before and after chemotherapy (

P
<
0.05

) and were also found in the SImax, TTP, SEE, PPE, WOR, and R values in the COG before and after chemotherapy (

P
<
0.05

). After chemotherapy, statistical differences were observed in the semiquantitative parameters of MRI between the two groups, with lower parameters such as Slope, SImax, SEE, and R values and higher parameters such as TTP, PPE, and WOR values in the STG than those in the COG (

P
<
0.05

). Conclusion. Paclitaxel combined with DHLI has definite efficacy in osteosarcoma chemotherapy, which is conducive to narrowing the lesion, controlling the disease, and reducing the occurrence of cardiac-related risk events. In addition, the semiquantitative parameters of dynamic contrast-enhanced MRI (DCE-MRI) have a high predictive value for the efficacy of chemotherapy, which can reflect the degree of tumor necrosis and contribute to a timely and objective assessment of the efficacy of osteosarcoma chemotherapy.
Rapid Residue Analysis of Phthalanilic Acid in Cereals and Oilseed Rape by High-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry
Authors: Zhang Aijuan , Zhou Li , Yu Miao , Feng Yizhi , Bian Yanli , Pan Jinju , Zuo Bojun , Liang Lin
Published: July 2022

Phthalanilic acid is widely used in wheat and oilseed rape fields in China, but there is no analysis method to detect its residues in wheat and oilseed rape substrates. To accurately evaluate the health and environmental impact of phthalanilic acid residues on wheat gains and rapeseeds, it is urgent to establish a reliable analytical method for its detection. In this study, a rapid and sensitive method was developed based on QuEChERS and LC-MS/MS to detect phthalanilic acid in cereals (wheat, rice, corn, and millet), wheat straw, and rapeseeds. Optimization of the detection conditions showed that the mobile phase of acetonitrile-0.1% formic acid solution had the best chromatographic resolution and sensitivity. The average recovery rates of phthalanilic acid in cereals, wheat straw, and rapeseeds ranged from 88% to 113% with relative standard deviations (RSDs) of 1%–6%. There were good linear relationships with the correlation coefficients (r) higher than 0.9990 at concentrations of 0.01–5 mg L−1. The limits of quantification (LOQ) for phthalanilic acid in cereals, wheat straw, and rapeseeds were 0.01 mg kg−1, 0.05 mg kg−1, and 0.02 mg kg−1, respectively. These results show that the method established in this study is convenient and reliable for routine monitoring of phthalanilic acid in cereals, wheat straw, and rapeseeds.
Application of Nanoscale Microparticle Technology in Medical Imaging Diagnosis and Treatment
Authors: Li Jingzhe
Published: July 2022

Nanotechnology is an alternative material manufacturing technology, and the research field involves a broad field of modern technology, especially in the field of high‐end manufacturing. Nanotechnology is a technique for studying the properties and applications of materials with structural dimensions in the range of 1 nanometer to 100 nanometers. Medical imaging refers to the technology and processing process of obtaining internal tissue images of the human body or a certain part of the human body in a noninvasive way for medical treatment or medical research; the acquired image can be further processed to restore the original image that was not clear enough to highlight some characteristic information in the image. The appearance of medical imaging has promoted the development of the medical field. The purpose of this paper is to study the application of nanoscale microparticle technology in medical imaging diagnosis and treatment. It is expected that the combination of nanotechnology and medical imaging will improve the accuracy of medical imaging diagnosis. This paper mainly introduces the general methods and technologies of technical development of medical imaging instruments and briefly shows the process of data and image analysis. The experimental results in this paper show that when other conditions remain unchanged, the image quality will change when the quality factor of the image changes. When the image quality is 60%, the image transmission rate is about 5.5FPS, which is relatively stable and can be used in the medical field.
Application Value of Evidence-Based Care in Patients with Lung Cancer Chemotherapy
Authors: Chen Ying , Xu Hong , Cheng Yun , Qian Yuan
Published: July 2022

Objective. The present research project is aimed at elucidating the application value of evidence-based care (EBC) in patients with lung cancer (LC) chemotherapy. Methods. Ninety-four advanced LC patients visited between March 2019 and February 2021 were retrospectively selected. Based on the type of care, 44 cases who used routine nursing were set as the control group (CG), and 50 patients who received EBC were included in the research group (RG). The pain degree, adverse mood, and individual fatigue of patients were assessed, using the Visual Analogue Scale (VAS), Self-Rating Anxiety/Depression Scale (SAS/SDS), and Cancer Fatigue Scale (CFS), respectively. Besides, patients were assessed for treatment compliance, self-efficacy, and life quality using the treatment compliance questionnaire, General Self-Efficacy Scale (GSES), and Quality of Life Questionnaire Core 30 (QLQ-C30), respectively. Results. The VAS, SAS, and SDS scores were lower in RG versus CG after nursing intervention. RG scored lower in the dimensions of physical, affective, and cognitive fatigue in terms of individual fatigue assessed by the CFS and higher in various domains of the QLQ-C30 score after nursing intervention. Besides, higher treatment compliance and self-efficacy were determined in RG as compared to CG. Conclusions. In addition to improving the treatment compliance, self-efficacy, and life quality of patients with LC chemotherapy, EBC can effectively alleviate their pain, adverse psychological mood, and individual fatigue, which deserves to be promoted in clinical application.
An Improved Steady-State and Transient Analysis of the RSG-GAS Reactor Core under RIA Conditions Using MTR-DYN and EUREKA-2/RR Codes
Authors: Pinem Surian , Dibyo Sukmanto , Luthfi Wahid , Wardhani Veronica Indriati Sri , Hartanto Donny
Published: July 2022

Steady-state and transient analysis of reactor core under Reactivity-Initiated Accident (RIA) conditions are important for reactor operation safety. The reactor dynamics are influenced by neutronic and thermal-hydraulic aspects of the core. In this study, steady-state and transient analysis under RIA conditions of the RSG-GAS multipurpose reactor was carried out using MTR-DYN and EUREKA-2/RR programs. Neutronic calculations were performed using a few group cross-sections generated by Serpent 2 with the latest cross-section data ENDF/B-VIII.0. Steady-state conditions were carried out with a nominal power of 30 MW, while transient under RIA conditions occurred because the control rod was pulled too quickly while the reactor operated. These transient RIA conditions were performed for two cases, during start-up with an initial power of 1 W, and within power range with an initial power of 1 MW. Thermal-hydraulic parameters considered in this study are reactor power, the temperature of the fuel, cladding, and coolant. The calculated maximum fuel temperature at a steady state is 126.02°C. Meanwhile, the calculated maximum fuel temperature during RIA conditions at the initial power of 1 W and 1 MW are 64.38°C and 137.14°C, respectively. There are no significant differences in thermal-hydraulic parameters between each used program. The thermal-hydraulic parameters such as the maximum temperature of the coolant, cladding, and fuel under this postulated RIA condition are within the acceptable reactor operation safety limits.
Real-World Effectiveness of Beta-Blockers versus Other Antihypertensives in Reducing All-Cause Mortality and Cardiovascular Events
Authors: Foch Caroline , Allignol Arthur , Hostalek Ulrike , Boutmy Emmanuelle , Hohenberger Thilo
Published: July 2022

Aim. The aim of the study was to compare the effectiveness of beta-blockers with other antihypertensive classes in reducing all-cause mortality, cardiovascular-related mortality and the risk of cerebrocardiovascular events. Methods. This noninterventional study was conducted within the UK Clinical Practice Research Datalink. Hypertensive patients who initiated antihypertensive monotherapy were allocated to one of five cohorts: beta-blockers; angiotensin-converting enzyme inhibitors (ACEi); angiotensin II receptor blockers (ARB); calcium channel blockers (CCB); and diuretics. Differences in outcomes were assessed using Cox proportional hazard models with competing risks. Results. A total of 44,404 patients were prescribed beta-blockers (75% atenolol), 132,545 ACEi, 12,018 ARB, 91,731 CCB, and 106,547 diuretics. At baseline, patients in the beta-blocker cohort presented more frequently with angina, arrhythmia, and atrial fibrillation. The risk of all-cause mortality was lower for those treated with ACEi, ARB, and CCB, and no difference was observed compared with diuretics (adjusted hazard ratio versus beta-blockers (98.75% CI), for ACEi 0.71 (0.61, 0.83), ARB 0.67 (0.51, 0.88), CCB 0.76 (0.66, 0.88), diuretics 1.06 (0.93, 1.22)). No differences were seen in the risk of cardiovascular mortality for patients treated with beta-blockers, ARB, CCB, and diuretics, while a lower risk in patients treated with ACEi was observed (ACEi 0.63 (0.43, 0.91), ARB 0.64 (0.32, 1.28), CCB 0.71 (0.49, 1.03), diuretics 0.97 (0.69, 1.37)). Conclusions. These data add to the limited pool of evidence from real-world studies exploring the effectiveness of beta-blockers versus other antihypertensive classes. Discrepancies to previously published studies might be partly explained by differences in the selected populations and in the follow-up time.
Study on the Action Mechanism of the Yifei Jianpi Tongfu Formula in Treatment of Colorectal Cancer Lung Metastasis Based on Network Analysis, Molecular Docking, and Experimental Validation
Authors: Zhu Wanli , Zhang Rundong , Ma Chenchao , Hu Yangyang , Shi Xuan , Wang Xiyu , Wu Xing , Ai Kaixing
Published: July 2022

Objective. The lung is the second most common site of colorectal cancer (CRC) metastasis. This study aims to investigate the therapeutic effects and potential action mechanisms of Yifei Jianpi Tongfu formula (YJTF) in CRC lung metastasis in a comprehensive and systematic way by network analysis, molecular docking, and experimental verification. Methods. The main ingredients in YJTF were screened from the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP) and Traditional Chinese Medicine Integrated Database (TCMID), and the disease-related targets from the Online Mendelian Inheritance in Man (OMIM) and GeneCards and the compound-related targets from SwissTargetPrediction were collected. Then, Metascape was used for pathway annotation and enrichment analysis, and meanwhile, a protein-protein interaction (PPI) network was constructed. Molecular docking was carried out to investigate interactions between the active compounds and the potential targets. The in vivo effect of YJTF on CRC lung metastasis was observed in a tail vein injection mouse model. Results. A total of 243 active compounds and 81 disease-related targets of YJTF were selected for analysis. The results of multiple network analysis showed that the core targets of YJTF were enriched onto various cancer-related pathways, especially focal adhesion and adherens junction. The results of molecular docking demonstrated that all core compounds (quercetin, kaempferol, luteolin, apigenin, and isorhamnetin) were capable of binding with AKT1, EGFR, SRC, ESR1, and PTGS2. Experimental validation in vivo demonstrated that YJTF combined with oxaliplatin could significantly reduce the number of lung metastases and improve the quality of life in mice. Further research suggested that YJTF inhibited CRC lung metastasis probably by modulating epithelial-to-mesenchymal transition (EMT). Conclusions. According to the analysis, YJTF can be considered as an effective adjuvant therapy for CRC lung metastasis.
Research Progress of Polycyclic Aromatic Hydrocarbons Pretreatment Methods and Application of Computer Simulation Technology for Prediction and Degradation of Electrochemical Concentration Detection
Authors: Chang He , Lu Yang
Published: July 2022

Polycyclic aromatic hydrocarbons (PAHs) are a class of organic compounds that are composed of aromatic rings containing only carbon and hydrogen atoms. They are one of the widespread environmental pollutants in the world. In recent years, many scholars have focused on the inhibition, formation mechanism, content of active components, and biodegradation effect of polycyclic aromatic hydrocarbons. They summarized the research progress of pretreatment methods for detection, but rarely discussed the experimental dataset for comprehensive analysis of pollution sources and the impact of different pretreatment technologies on the extraction of different substrates. What is more, computer simulation has not been mentioned. In this study, the pollution sources of polycyclic aromatic hydrocarbons (PAHs) are reviewed, and the related applications of various pretreatment methods such as gel permeation chromatography (GPC) are summarized. Finally, the computer simulation of the response surface method is introduced. The concentration of polycyclic aromatic hydrocarbons is tested or predicted by combining the neural network with the alternating trilinear decomposition (ATLD) algorithm, artificial population algorithm (ABC), and hierarchical genetic algorithm (HGA). Its future development trend is discussed and prospected, which provides a reference for solving the pollution problem. We look forward to providing help for the follow-up research of scholars in this field.
A New Hypoxia-Related Prognostic Risk Score (HPRS) Model Was Developed to Indicate Prognosis and Response to Immunotherapy for Lung Adenocarcinoma
Authors: Yang Xiahui , Liang Minchao , Yu Zhiqi , Fan Jiaquan
Published: July 2022

Background. Hypoxia is a typical microenvironmental feature of most solid tumors, affecting a variety of physiological processes. We developed a hypoxia-related prognostic risk score (HPRS) model to reveal tumor microenvironment (TME) and predict prognosis of lung adenocarcinoma (LUAD). Methods. LUAD sample expression data were from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Weighted gene co-expression network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) Cox regression identified hypoxia-related genes (HRGs) to create HPRS. The prognostic value, genetic mutation and TME, and therapeutic response of distinct HPRS groups were analyzed. Univariate and multivariate Cox regression analysis identified independent factors associated with the prognosis of LUAD. A decision tree based on HPRS and clinicopathological variables was established using the classification system based on decision tree algorithm. A nomogram was constructed with important clinical features and HPRS by the RMS package. Results. A HPRS model with five HRGs was developed and verified in two separate cohorts of GEO. HPRS model divided patients with LUAD into two groups. High HPRS was related to high probability of genetic alterations. HPRS could predict the prognosis, TME, and sensitivity to immunotherapy/chemotherapy of LUAD. The decision tree defined four risk subgroups with significant OS differences. Nomogram with integrated HPRS and clinical features had acceptable accuracy in predicting LUAD prognosis. Conclusions. A HPRS model was developed to evaluate prognosis, genetic alterations, TME, and response to immunotherapy, which may provide theoretical reference for the study of molecular mechanism of hypoxia in LUAD.
Internet of Vehicles Resource Scheduling Based on Blockchain and Game Theory
Authors: Chen Jing , Li Tong
Published: July 2022

With the popularity of on-board intelligent devices, the number of vehicle computing intensive applications is also increasing rapidly. Due to the high mobility and limited computing power of the vehicle, and the extensive and changing demand for computing resources of the vehicle terminal, the vehicle often has insufficient computing power. In order to meet the needs of intensive computing applications of vehicle terminals, the computing tasks of vehicles can be unloaded to edge cloud servers (ECSs) with rich resources and high performance to enhance the computing power of vehicle terminals. However, the resource charge of ECS is high, and the scheme needs to consider such issues as ECS signal coverage, long task transmission delay caused by network congestion, and insufficient computing capacity of ECS. Therefore, this study considers unloading the computing tasks of vehicles with insufficient computing resources to nearby vehicles with redundant computing capacity and proposes a resource scheduling method for the Internet of vehicles based on blockchain and game theory. The scheduling of computing resources can reduce the computing workload of buyers’ vehicles and improve the operation efficiency of the whole vehicle network.
Improving the Security of Video Embedding Using the CFP-SPE Method
Authors: Panneerselvam Karthick , Rajalakshmi K. , Helen Josephine V. L. , Rajan Dhivya , Visalatchi L. , Mahesh K. , Tesfaye Meroda
Published: July 2022

With the amount of data being transferred on a daily basis, it is becoming increasingly dangerous to save data on the Internet in the face of intruders or hackers. This study paper is one of the most effective ways to transmit information in a secure and confidential manner. The authors previously disclosed a way for embedding a secret video inside a cover video in their prior work. The writers have implemented a number of techniques to incorporate the secret video. The current work improves on the existing approach by including encryption and decryption concepts into the video embedding process. The secret data for either a large or little amount of information is put on the cover video utilising the embedding technique. Our proposed method combines compression, encryption, decryption, and secret information embedding to provide a more secure data transfer.
Treatment of Mixed Azo Dyes in an Aerobic Sequential Batch Reactor and Toxicity Assessment Using Vigna radiata
Authors: Akshaya Vidhya T. , Veena Gayathri K. , Senthil kumar P. , Rangasamy Gayathri , Kathawala Tasneem M.
Published: July 2022

Azo dyes are the most widely used dyes in the textile industry due to their stability, but their redundancy to degradation is of significant concern, particularly to aquatic ecosystems. In the present study, a lab-scale aerobic sequential batch reactor (SBR) was operated to analyze the degradation of mixed reactive azo dyes at a concentration of 100–1000 mg/L. The chemical oxygen demand (COD) removal increased from 34% to 61.15% and then dropped to 21.16% at the highest used concentration. The biochemical oxygen demand (BOD) removal decreased from 63% to 55.55% to 28.14% with an increasing dye concentration. The biosorption experiment and dried activated sludge (DAS) successfully removed about 0.300 mg of dyes by absorption within 2 hours. A toxicity assessment was carried out by employing a phytotoxicity test on Vigna radiata. The percentage of germination was used to detect the toxic effects of untreated dye-containing wastewater on plant growth. The treated wastewater showed 100% germination compared to 70% in untreated wastewater containing 100 mg/L mixed dyes, confirming the treatment’s efficacy.
Effect Analysis of Midwife Education and Training with PDCA Model
Authors: Jin Jing , Chen Jie , Zhao Yuan , Qiu Chunbo
Published: July 2022

With the improvement of social living standards, pregnant women have higher and higher requirements for health and medical personnel. As the main body of medical service personnel, the service objects of midwives are increasing rapidly, while the existing working conditions and abilities of midwives are difficult to meet the growing medical needs of pregnant women. In order to improve the imbalance between supply and demand between limited medical resources and patients’ medical treatment, this paper proposed to use PDCA model to educate and train midwives in order to improve their professional ability and work efficiency. Based on the analysis of the structure and functional principle of PDCA model, according to the working requirements of midwives, PDCA model was used to provide midwives with scientific teaching plan, implementation scheme, inspection requirements, and result evaluation methods. In order to test the effect of the application of this model, a group of hospitalized pregnant women were selected as samples and randomly divided into control group and observation group. Through comparative experiments, the effectiveness of PDCA model in midwife education and training was verified. The experimental results showed that the scores of midwife and patient satisfaction, theory and operation skills in the observation group were higher than those in the control group. Compared with the conventional nursing mode, the use of PDCA cycle mode to educate and train midwives had not only effectively improved the theoretical knowledge and professional skills of nurses, but also significantly improved the nursing and delivery monitoring ability of pregnant women. This study has certain reference and guiding significance for clinical medicine and other related application fields.
[Retracted] Histone Deacetylase9 Represents the Epigenetic Promotion of M1 Macrophage Polarization and Inflammatory Response via TLR4 Regulation
Authors: Cao Xi , Zhang Man , Li Hui , Chen Kaiming , Wang Yong , Yang Jia
Published: July 2022

Atherosclerosis is a chronic inflammatory response mediated by various factors, where epigenetic regulation involving histone deacetylation is envisaged to modulate the expression of related proteins by regulating the binding of transcription factors to DNA, thereby influencing the development of atherosclerosis. The mechanism of atherosclerosis by histone deacetylation is partly known; hence, this project aimed at investigating the role of histone deacetylase 9 (HDAC9) in atherosclerosis. For this purpose, serum was separated from blood samples following clotting and centrifugation from atherosclerotic and healthy patients (n = 40 each), and then, various tests were performed. The results indicated that toll‐like receptor 4 (TLR4) was not only positively correlated to the HDAC9 gene, but was also upregulated in atherosclerosis, where it was also significantly upregulated in the atherosclerosis cell model of oxidized low‐density lipoprotein‐induced macrophages. Conversely, the TLR4 was significantly downregulated in instances of loss of HDAC9 function, cementing the bridging relationship between HDAC9 and macrophage polarization, where the HDAC9 was found to upregulate M1 macrophage polarization which translated into the release of higher content of proinflammatory cytokines such as interleukin‐1beta (IL‐1β) and tumor necrosis factor‐alpha (TNF‐α), which tend to significantly decrease following the deletion of TLR4. Hence, this study reports novel relation between epigenetic control and atherosclerosis, which could partly be explained by histone deacetylation.
Application of Intelligent Technology on Tunnel Steel Structure Factory
Authors: He Chenyang
Published: July 2022

At present, the construction of tunnel steel structure factories has been common, but most of them are still on the low end. In addition, the manual processing modes face certain problems, such as high waste rate, low efficiency, and discrete welding of steel components. To address these problems, this paper introduces an intelligent management cloud platform, aiming to realize unmanned control methods and construct an intelligent tunnel steel component processing plant. There are four main production lines in the intelligent steel structure factory. First, an intelligent production line of a tunnel grille arch effectively improves the production efficiency, production quality, and dust removal effect of the grille arch through the automatic welding technology of a reinforcement mechanism-based welding robot. Second, a processing line of a steel pipe for tunnel construction improves the overall processing efficiency, saves costs, and reduces work intensity by using an intelligent numerical control system, a pneumatic clamping device, a plasma cutting hole assembly, and a 360-degree automatic rotation system. Third, an automatic feeding platform of section steel arch production line adopts the six-axis robot sensor clamping connecting plate positioning and six-axis robot sensing three-plane automatic welding system, which not only compensates for the defects of manual production but also realizes the reduction, increases efficiency, and improves welding quality and precision. Fourth, an automatic steel mesh production line saves much labor and enhances site management and production efficiency through vertical and horizontal reinforcement pay-off racks. Overall, in this study, the construction goals of informatization, intellectualization, and personnel downsizing of the tunnel steel structure processing have been achieved.
Poly-3-Methyl Aniline-Assisted Spherical PbS Quantum Dots through the Ionic Adsorption Deposition Method as a Novel and Highly Efficient Photodetector in UV, Vis, and NIR Regions
Authors: Hadia N. M. A. , Eid Sayeda , Shaban Mohamed , Mohamed S. H. , Elsayed Asmaa M. , Ahmed Ashour M. , Alzaid Meshal , Abdelazeez Ahmed Adel A. , El Malti Wassim , Rabia Mohamed
Published: July 2022

This study describes the preparation and characterization of glass/poly-3-methyl aniline (P3MA)/PbS quantum dot (QD) optoelectronic photodetector to detect and sense the light in broad spectral regions of UV, Vis, and NIR. This work is carried out to solve the drawbacks of other studs that prepare detectors in just one or two optical regions. Previous studies have used high-priced techniques. The deposition of P3MA on the glass surface was carried out by in situ oxidation process. Then, this polymer film was used to assist the deposition of PbS-QD particles through the ionic adsorption deposition method. The latter was performed using four different concentrations of Pb(NO3)2 solution (0.01, 0.03, 0.05, and 0.07 M) to form four P3MA/PbS composites: I, II, III, and IV, respectively. The chemical structure, morphologies, and electrical and optical properties of these composites were determined using different analytical tools. The SEM confirmed the formation of spherical QD particles of PbS on the P3MA surface. The TEM analysis showed that the composite has an average size of 5 nm, with the interatomic distances of 0.4 nm. Furthermore, the optical band gap values were 1.53, 1.52, 1.50, and 1.51 eV, respectively. The optoelectronic device could detect and sense light from 390 to 636 nm under various optical wavelengths. The produced current density ([Formula: see text]) values decreased from 0.029 mA.cm-2 at 390 nm to 0.022 mA.cm-2 at 500 nm and then increased until 0.024 mA.cm-2 at 636 nm. The light sensing was determined through the photoresponsivity ([Formula: see text]) and detectivity ([Formula: see text]) parameters, in which the photodetector has [Formula: see text] and [Formula: see text] values of 0.29 mA.cm-2 and [Formula: see text] Jones, respectively. Finally, a simple mechanism was proposed to explain the light sensing through the prepared optoelectronic device. Soon, our team works on the industrial applications of this optoelectronic device in the industry field related to the great optoelectronic device technical properties and its low cost and easy preparation.
Security Research in Personnel Electronic File Management Based on Blockchain Technology
Authors: Wang Hongbing , Zhang Jian
Published: July 2022

Compared with traditional files, electronic personnel files have the characteristics of the economy, environmental protection, convenience, and sharing and are gradually replacing traditional paper files. However, the development of electronic archives is still in its infancy, and there are still many problems, including the professional quality of personnel, information management, and the security of electronic archives storage. As an emerging technology, blockchain technology has the characteristics of decentralization, immutability, and traceability. This paper applies blockchain technology in the management of electronic archives, overcomes the internal distortion and insecurity of electronic archives, and designs an electronic archives management module based on blockchain technology. Through the application in some schools, the effectiveness and practicability of the algorithm are proved.