bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Study of Perfobond Rib Shear Connector under Lateral Force
Authors: Wang Xuewei , He Qiuxia , An Zhiwen , Liu Guojun , Wen Xingke , Wang Yongqiang , Zhong Zhenxiao
Published: September 2021

A series of full-scale pushed out tests were performed on the Perfobond rib shear connector. The tests were designed to examine the performance of the Perfobond rib shear connector under different rib hole sizes and shapes, reinforcing bar sizes, rib thicknesses, as well as the presence of lateral forces. It has been revealed from the test results that the rib hole size and reinforcement diameter may not act independently, and the influence of one’s size is actually dependent on the size of the other one. The lateral forces also affect the performance of the shear connector; for example, the capacity of the shear connector would be larger under compression than under tension. The existence of transverse pretension stress accelerated the cracking of concrete, leading to the strength and stiffness of concrete, perforated plate, and reinforcing rebars unable to fully exert their effect. In addition, the constraint effect of transverse stress improved the strength and stiffness of concrete and delayed the concrete cracking, bringing the strength and stiffness of concrete, perforated plate, and reinforcing rebars into full play, and resulting in a significant improvement in the shear capacity of Perfobond rib shear connectors.
An Economical and Mechanical Investigation on Local Post-Weld Heat Treatment for Stiffened Steel Plates in Bridge Structures
Authors: Hirohata Mikihito , Nozawa Shuhei , Jármai Károly
Published: September 2021

A heat treatment is effective for reducing the residual stress of the welded structures. A post-weld heat treatment (PWHT) requires a large heating apparatus (furnace). It requires a high energy, a long time, and a high cost. For examining the possibility of cost and energy saving in PWHT work, an economical and mechanical investigation of the local PWHT to stiffened plate members in steel bridges was conducted. The expense of apparatus for the furnace PWHT was 1.5 times higher than that of local PWHT by sheet-type ceramic heaters. When the number of heater units was reduced and were repeatedly used, the expense for the apparatus became lower. However, it took longer to complete the heat treatment than with the furnace PWHT or the local PWHT with full heater units. The thermal elastic-plastic finite element (FE) analysis examined the effect of local PWHT. The tendency of the stress distribution after the local PWHT differed from the welding residual stress or the stress after the furnace PWHT because of the temperature difference between the heated and the non-heated parts of the local PWHT. However, the effect of residual stress relief by the local PWHT could be almost the same as that of the furnace PWHT.
Spatiotemporal Characteristics of the Surface Urban Heat Island and Its Driving Factors Based on Local Climate Zones and Population in Beijing, China
Authors: Zhang Yatong , Li Delong , Liu Laibao , Liang Ze , Shen Jiashu , Wei Feili , Li Shuangcheng
Published: September 2021

The increasing degree of urbanization has continuously aggravated the surface urban heat island (sUHI) effect in China. To investigate the correlation between spatiotemporal changes of sUHI and urbanization in Beijing, land surface temperature in summer from 2000 to 2017 and the distribution of local climate zones (LCZs) in 2003, 2005, 2010, and 2017 was retrieved using remote sensing data and used to analyze the sUHI area and intensity change. The statistical method GeoDetector was utilized to investigate the explanatory ability of LCZs and population as the driving factors. The year of 2006 was identified as the main turning year for sUHI evolution. The variation the sUHI from 2000 showed first an increasing trend, and then a decreasing one. The sUHI pattern changed before and after 2009. Before 2009, the sUHI mainly increased in the suburbs, and then, the enhancement area moved to the central area. The sUHI intensity change under different LCZ conversion conditions showed that the LCZ conversion influences the sUHI intensity significantly. Based on population distribution data, we found that the relationship between population density and sUHI gets weaker with increasing population density. The result of GeoDetector indicated that the LCZ is the main factor influencing the sUHI, but population density is an important auxiliary factor. This research reveals the sUHI variation pattern in Beijing from 2000 and could help city managers plan thermally comfortable urban environments with a better understanding of the effect of urban spatial form and population density on sUHIs.
A Study on Singapore’s Ageing Population in the Context of Eldercare Initiatives Using Machine Learning Algorithms
Authors: Rangaswamy Easwaramoorthy , Periyasamy Girija , Nawaz Nishad
Published: September 2021

Ageing has always directly impacted the healthcare systems and, more specifically, the eldercare costs, as initiatives related to eldercare need to be addressed beyond the regular healthcare costs. This study aims to examine the general issues of eldercare in the Singapore context, as the population of the country is ageing rapidly. The main objective of the study is to examine the eldercare initiatives of the government and their likely impact on the ageing population. The methodology adopted in this study is Cross-Industry Standard Process for Data Mining (CRISP-DM). Reviews related to the impact of an ageing population on healthcare systems in the context of eldercare initiatives were studied. Analysis methods include correlation and machine learning algorithms, such as Decision Tree, Logistic Regression and Receiver Operating Characteristics curve analysis. Suggestions have been provided for various healthcare and eldercare systems’ initiatives and needs that are required to transform to cope with the ageing population.
Systemic Profiles of microRNAs, Redox Balance, and Inflammation in Lung Cancer Patients: Influence of COPD
Authors: Qin Liyun , Guitart Maria , Curull Víctor , Sánchez-Font Albert , Duran Xavier , Tang Jun , Admetlló Mireia , Barreiro Esther
Published: September 2021

Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients. Whether systemic alterations of those events may also take place in LC patients remains unknown. Our objectives were to assess the plasma levels of microRNAs, redox balance, and cytokines in LC patients with/without COPD. MicroRNAs (RT-PCR) involved in LC, oxidized DNA, MDA-protein adducts, GSH, TEAC, VEGF, and TGF-beta (ELISA) were quantified in plasma samples from non-LC controls (n = 45), LC-only patients (n = 32), and LC-COPD patients (n = 91). In LC-COPD patients compared to controls and LC-only, MDA-protein adduct levels increased, while those of GSH decreased, and two patterns of plasma microRNA were detected. In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. Correlations were found between clinical and biological variables. A differential expression profile of microRNAs was detected in patients with LC. Moreover, in LC patients with COPD, plasma oxidative stress levels increased, whereas those of GSH declined. Systemic oxidative and antioxidant markers are differentially expressed in LC patients with respiratory diseases, thus implying its contribution to the pathogenesis of tumorigenesis in these patients.
Is the Exposome Involved in Brain Disorders through the Serotoninergic System?
Authors: Sarrouilhe Denis , Defamie Norah , Mesnil Marc
Published: September 2021

Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic monoamine acting as a neurotransmitter in the central nervous system (CNS), local mediator in the gut, and vasoactive agent in the blood. It has been linked to a variety of CNS functions and is implicated in many CNS and psychiatric disorders. The high comorbidity between some neuropathies can be partially understood by the fact that these diseases share a common etiology involving the serotoninergic system. In addition to its well-known functions, serotonin has been shown to be a mitogenic factor for a wide range of normal and tumor cells, including glioma cells, in vitro. The developing CNS of fetus and newborn is particularly susceptible to the deleterious effects of neurotoxic substances in our environment, and perinatal exposure could result in the later development of diseases, a hypothesis known as the developmental origin of health and disease. Some of these substances affect the serotoninergic system and could therefore be the source of a silent pandemic of neurodevelopmental toxicity. This review presents the available data that are contributing to the appreciation of the effects of the exposome on the serotoninergic system and their potential link with brain pathologies (neurodevelopmental, neurodegenerative, neurobehavioral disorders, and glioblastoma).
Phase I/II Study of LDE225 in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Metastatic Pancreatic Cancer
Authors: Pijnappel Esther N. , Wassenaar Nienke P. M. , Gurney-Champion Oliver J. , Klaassen Remy , van der Lee Koen , Pleunis-van Empel Marjolein C. H. , Richel Dick J. , Legdeur Marie C. , Nederveen Aart J. , van Laarhoven Hanneke W. M. , Wilmink Johanna W.
Published: September 2021

Background: Desmoplasia is a central feature of the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC). LDE225 is a pharmacological Hedgehog signaling pathway inhibitor and is thought to specifically target tumor stroma. We investigated the combined use of LDE225 and chemotherapy to treat PDAC patients. Methods: This was a multi-center, phase I/II study for patients with metastatic PDAC establishing the maximum tolerated dose of LDE225 co-administered with gemcitabine and nab-paclitaxel (phase I) and evaluating the efficacy and safety of the treatment combination after prior FOLFIRINOX treatment (phase II). Tumor microenvironment assessment was performed with quantitative MRI using intra-voxel incoherent motion diffusion weighted MRI (IVIM-DWI) and dynamic contrast-enhanced (DCE) MRI. Results: The MTD of LDE225 was 200 mg once daily co-administered with gemcitabine 1000 mg/m2 and nab-paclitaxel 125 mg/m2. In phase II, six therapy-related grade 4 adverse events (AE) and three grade 5 were observed. In 24 patients, the target lesion response was evaluable. Three patients had partial response (13%), 14 patients showed stable disease (58%), and 7 patients had progressive disease (29%). Median overall survival (OS) was 6 months (IQR 3.9–8.1). Blood plasma fraction (DCE) and diffusion coefficient (IVIM-DWI) significantly increased during treatment. Baseline perfusion fraction could predict OS (>222 days) with 80% sensitivity and 85% specificity. Conclusion: LDE225 in combination with gemcitabine and nab-paclitaxel was well-tolerated in patients with metastatic PDAC and has promising efficacy after prior treatment with FOLFIRINOX. Quantitative MRI suggested that LDE225 causes increased tumor diffusion and works particularly well in patients with poor baseline tumor perfusion.
Rapid Escalation of High-Volume Exercise during Caloric Restriction; Change in Visceral Adipose Tissue and Adipocytokines in Obese Sedentary Breast Cancer Survivors
Authors: Fabian Carol J. , Klemp Jennifer R. , Marchello Nicholas J. , Vidoni Eric D. , Sullivan Debra K. , Nydegger Jennifer L. , Phillips Teresa A. , Kreutzjans Amy L. , Hendry Bill , Befort Christie A. , Nye Lauren , Powers Kandy R. , Hursting Stephen D. , Giles Erin D. , Hamilton-Reeves Jill M. , Li Bing , Kimler Bruce F.
Published: September 2021

Aerobic exercise reduces risk for breast cancer and recurrence and promotes visceral adipose tissue (VAT) loss in obesity. However, few breast cancer survivors achieve recommended levels of moderate to vigorous physical activity (MVPA) without supervision. In a two-cohort study, feasibility of 12 weeks of partially supervised exercise was started concomitantly with caloric restriction and effects on body composition and systemic risk biomarkers were explored. In total, 22 obese postmenopausal sedentary women (including 18 breast cancer survivors) with median age of 60 and BMI of 37 kg/m2 were enrolled. Using personal trainers twice weekly at area YMCAs, MVPA was escalated to ≥200 min/week over 9 weeks. For cohort 2, maintenance of effect was assessed when study provided trainer services were stopped but monitoring, group counseling sessions, and access to the exercise facility were continued. Median post-escalation MVPA was 219 min/week with median 12-week mass and VAT loss of 8 and 19%. MVPA was associated with VAT loss which was associated with improved adiponectin:leptin ratio. In total, 9/11 of cohort-2 women continued the behavioral intervention for another 12 weeks without trainers. High MVPA continued with median 24-week mass and VAT loss of 12 and 29%. This intervention should be further studied in obese sedentary women.
Chemotherapy in Neuroendocrine Tumors
Authors: Das Satya , Al-Toubah Taymeyah , Strosberg Jonathan
Published: September 2021

The role for cytotoxic chemotherapy in patients with well-differentiated neuroendocrine tumors (NETs) remains debated. Compared to patients with poorly differentiated neuroendocrine carcinomas (NECs) where chemotherapy is utilized ubiquitously, chemotherapy may play a more select role in patients with certain types of NETs (e.g., pancreatic tumors, higher grade tumors, and tumors possessing DNA damage repair defects). The primary types of chemotherapy that have been tested in patients with NETs include alkylating agent- and platinum agent-based combinations. Across regimens, chemotherapy appears to elicit greater antitumor activity in patients with pancreatic or grade 3 NETs. The role for chemotherapy in lower grade extra-pancreatic NETs remains undefined. Furthermore, while chemotherapy has demonstrated clinically meaningful benefit for patients in the systemic setting, its role in the adjuvant or neoadjuvant setting is as-of-yet undetermined. Finally, efforts to combine chemotherapy with targeted therapy and peptide receptor radionuclide therapy are ongoing, in hopes of improving the cytoreductive treatment options for patients with NETs.
Immunomodulating Therapies in Breast Cancer—From Prognosis to Clinical Practice
Authors: Schmidt Marcus , Heimes Anne-Sophie
Published: September 2021

The role of the immune system in breast cancer has been debated for decades. The advent of technologies such as next generation sequencing (NGS) has elucidated the crucial interplay between somatic mutations in tumors leading to neoantigens and immune responses with increased tumor-infiltrating lymphocytes and improved prognosis of breast cancer patients. In particular, triple-negative breast cancer (TNBC) has a higher mutational burden compared to other breast cancer subtypes. In addition, higher levels of tumor-associated antigens suggest that immunotherapies are a promising treatment option, specifically for TNBC. Indeed, higher concentrations of tumor-infiltrating lymphocytes are associated with better prognosis and response to chemotherapy in TNBC. An important target within the cancer immune cell cycle is the “immune checkpoint”. Immune checkpoint inhibitors (ICPis) block the interaction of certain cell surface proteins that act as “brakes” on immune responses. Recent studies have shown that ICPis improve survival in both early and advanced TNBC. However, this comes at the price of increased toxicity, particularly immune-mediated toxicity. As an alternative approach, individualized mRNA vaccination strategies against tumor-associated neoantigens represent another promising approach leading to neoantigen-specific immune responses. These novel strategies should help to improve treatment outcomes, especially for patients with triple negative breast cancer.
Metal-Organic Frameworks Derived Catalyst for High-Performance Vanadium Redox Flow Batteries
Authors: Ou Yun-Ting , Kabtamu Daniel Manaye , Bayeh Anteneh Wodaje , Ku Hung-Hsien , Kuo Yu-Lin , Wang Yao-Ming , Hsu Ning-Yih , Chiang Tai-Chin , Huang Hsin-Chih , Wang Chen-Hao
Published: September 2021

Vanadium redox flow battery (VRFB) is one of the most promising technologies for grid-scale energy storage applications because of its numerous attractive features. In this study, metal-organic frameworks (MOF)-derived catalysts (MDC) are fabricated using carbonization techniques at different sintering temperatures. Zirconium-based MOF-derived catalyst annealed at 900 °C exhibits the best electrochemical activity toward VO2+/VO2+ redox couple among all samples. Furthermore, the charge-discharge test confirms that the energy efficiency (EE) of the VRFB assembled with MOF-derived catalyst modified graphite felt (MDC-GF-900) is 3.9% more efficient than the VRFB using the pristine graphite felt at 100 mA cm−2. Moreover, MDC-GF-900 reveals 31% and 107% higher capacity than the pristine GF at 80 and 100 mA cm−2, respectively. The excellent performance of MDC-GF-900 results from the existence of oxygen-containing groups active sites, graphite structure with high conductivity embedded with zirconium oxide, and high specific surface area, which are critical points for promoting the vanadium redox reactions. Because of these advantages, MDC-GF-900 also possesses superior stability performance, which shows no decline of EE even after 100 cycles at 100 mA cm−2.
High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders
Authors: Saxena Sarah , Kruys Véronique , De Jongh Raf , Vamecq Joseph , Maze Mervyn
Published: September 2021

Aseptic surgical trauma provokes the release of HMGB1, which engages the innate immune response after binding to pattern-recognition receptors on circulating bone marrow-derived monocytes (BM-DM). The initial systemic inflammation, together with HMGB1, disrupts the blood–brain barrier allowing penetration of CCR2-expressing BM-DMs into the hippocampus, attracted by the chemokine MCP-1 that is upregulated by HMGB1. Within the brain parenchyma quiescent microglia are activated and, together with the translocated BM-DMs, release proinflammatory cytokines that disrupt synaptic plasticity and hence memory formation and retention, resulting in postoperative cognitive decline (PCD). Neutralizing antibodies to HMGB1 prevents the inflammatory response to trauma and PCD.
Machine Learning Assisted Classification of Cell Lines and Cell States on Quantitative Phase Images
Authors: Belashov Andrey V. , Zhikhoreva Anna A. , Belyaeva Tatiana N. , Salova Anna V. , Kornilova Elena S. , Semenova Irina V. , Vasyutinskii Oleg S.
Published: September 2021

In this report, we present implementation and validation of machine-learning classifiers for distinguishing between cell types (HeLa, A549, 3T3 cell lines) and states (live, necrosis, apoptosis) based on the analysis of optical parameters derived from cell phase images. Validation of the developed classifier shows the accuracy for distinguishing between the three cell types of about 93% and between different cell states of the same cell line of about 89%. In the field test of the developed algorithm, we demonstrate successful evaluation of the temporal dynamics of relative amounts of live, apoptotic and necrotic cells after photodynamic treatment at different doses.
Developmental Dysplasia of the Hip: How Does Social Media Influence Patients and Caregivers Seeking Information?
Authors: Para Ashok , Batko Brian , Ippolito Joseph , Hanna Gabriel , Edobor-Osula Folorunsho
Published: September 2021

Developmental dysplasia of the hip (DDH) is a common orthopaedic condition affecting newborns. The rapid and vast adoption of social media has changed how we access medical information. The aim of this study was to deepen the understanding of the impact of social media as a tool used by caregivers. A search was performed on the Facebook (FB), Twitter (TW), and YouTube (YT) platforms. Information was quantitatively assessed by category, and number of posts and users. Comments and posts from the social medial platforms were then qualitatively assessed by using a thematic analysis. 16 Facebook pages and groups, 135 YouTube videos, and 5 Twitter accounts related to DDH were identified across 15 countries. A total of 25,471 comments/tweets were recorded. Across the social media platforms, the most common comments theme was “information sharing” (36.1%). Facebook groups had a significantly greater number of comments that were characterized as “social media as a second opinion” in comparison to YouTube videos (p < 0.001), whereas YouTube videos had significantly fewer comments characterized as “sharing information” in comparison to Facebook groups and Facebook pages (p < 0.0001). Orthopaedic surgeons may utilize caregiver presence on social media as an opportunity to help share accurate information and facilitate informed decision-making.
Development of Social Skills in Kindergarten: A Latent Class Growth Modeling Approach
Authors: Zhu Yan-Tong , Li Xiang , Jiao Dan-Dan , Tanaka Emiko , Tomisaki Etsuko , Watanabe Taeko , Sawada Yuko , Zhu Zhu , Ajmal Ammara , Matsumoto Munenori , Anme Tokie
Published: September 2021

Social skills acquired during early childhood are often the foundation for success later in life. Using a nationwide survey dataset in Japan, this study aims to explore the multiple growth trajectories of social skills among children in kindergarten by using a latent class growth modeling approach. It also examines whether, and to what extent, the home-rearing environment at early age predict trajectories of social skills development. Children in this study were assessed on social skills at three waves, four home-rearing environment dimensions (human stimulation, social stimulation, avoidance of punishment, and social support for parenting) and demographic background were measured at wave 1. The results indicated that three distinct growth trajectories of social skills existed during kindergarten: high increase levels, moderate increase levels, and decreased levels. The avoidance of punishment and children’s gender significantly predicted the growth trajectories of social skills. Thus, the results suggest that more attention should be paid to the home-rearing environment and boys.
Laboratory Study on Non-Destructive Evaluation of Polyethylene Liquid Storage Tanks by Thermographic and Ultrasonic Methods
Authors: Behravan Amir , deJong Matthew M. , Brand Alexander S.
Published: September 2021

High-density polyethylene (HDPE) above-ground storage tanks (AST) are used by highway agencies to store liquid deicing chemicals for the purpose of road maintenance in the winter. A sudden AST failure can cause significant economic and environmental impacts. While ASTs are routinely inspected to identify signs of aging and damage, current methods may not adequately capture all defects, particularly if they are subsurface or too small to be seen during visual inspection. Therefore, to improve the ability to identify potential durability issues with HDPE ASTs, additional non-destructive evaluation (NDE) techniques need to be considered and assessed for applicability. Specifically, this study investigates the efficiency of using infrared thermography (IRT) as a rapid method to simultaneously examine large areas of the tank exterior, which will be followed by closer inspections with conventional and phased array ultrasonic testing (UT) methods. Results show that IRT can help to detect defects that are shallow, specifically located within half of the tank’s wall thickness from the surface. UT has the ability to detect all defects at any depth. Moreover, phased array UT helps to identify stacked defects and characterize each defect more precisely than IRT.
Thermal Conductivity of Multi-Sized Porous Thermal Barrier Coatings at Micro and Nano Scales after Long-Term Service at High Temperatures
Authors: Gao Pei-Hu , Zeng Sheng-Cong , Jin Can , Zhang Bo , Chen Bai-Yang , Yang Zhong , Guo Yong-Chun , Liang Min-Xian , Li Jian-Ping , Li Quan-Ping , Lu Yong-Qing , Jia Lu , Zhao Dan
Published: September 2021

Thermal barrier coatings with multi-sized porous structure at micro and nano scales were prepared with hollow spherical YSZ powders and polypropylene powders through atmospheric plasma spraying. The thermal conductivities of the multi-sized thermal barrier coatings after a long-term serving at high temperature were tested through laser flash heating method. Meanwhile, the physical models of thermal barrier coatings with multi-sized porous structure at micro and nano scales were constructed through Ansys Workbench. The evolutions of thermal conductivity of thermal barrier coatings with multi-sized pores after long-term service at 1100 °C were investigated through computation. It was found that the thermal conductivity of the coating increased with the extension of the serving time. When the serving time reached 60 days, the thermal conductivity of the coating tended to be stable and close to the compacted bulk. The computational results were consistent with the tested ones, which could be helpful to explain the thermal conducting evolution in thermal barrier coatings with multi-sized porous structure at nano and micro scales after long-term serving at high temperature.
Design and Preparation of Nanoporous Cu/Ag Multilayer Films
Authors: Wang Yufei , Zhang Shuangle , Wu Zefeng , Fan Yong , Chen Huaqiang , Meng Qingning , Yan Yang , Hu Zhaoyi , Wang Jing , Fu Engang
Published: September 2021

Cu30Al70 and Ag30Al70 multilayer precursor films were prepared by magnetron sputtering, respectively. Then the nanoporous Cu/Ag multilayer composite films were successfully prepared by selecting the appropriate H2SO4 solution as the dealloying solution. It was found that the nanoporous structure was stable in the dealloying solution. The morphology and structure of nanoporous multilayer films are mainly related to the phase composition of precursors. The structure of nanoporous multilayers can be simply regarded as the superposition of single-layer structures. Our work shows that nanoporous multilayers can be well-prepared by magnetron sputtering combined with dealloying.
Characteristics and Predictors of Progression Interstitial Lung Disease in Rheumatoid Arthritis Compared with Other Autoimmune Disease: A Retrospective Cohort Study
Authors: Mena-Vázquez Natalia , Rojas-Gimenez Marta , Romero-Barco Carmen María , Manrique-Arija Sara , Hidalgo Conde Ana , Arnedo Díez de los Ríos Rocío , Cabrera César Eva , Ortega-Castro Rafaela , Espildora Francisco , Aguilar-Hurtado María Carmen , Añón-Oñate Isabel , Pérez-Albaladejo Lorena , Abarca-Costalago Manuel , Ureña-Garnica Inmaculada , Velloso-Feijoo Maria Luisa , Redondo-Rodriguez Rocio , Fernández-Nebro Antonio
Published: September 2021

Objectives: To describe the characteristics and progression of interstitial lung disease in patients with associated systemic autoimmune disease (ILD-SAI) and to identify factors associated with progression and mortality. Patients and methods: We performed a multicenter, retrospective, observational study of patients with ILD-SAI followed between 2015 and 2020. We collected clinical data and performed pulmonary function testing and high-resolution computed tomography at diagnosis and at the final visit. The main outcome measure at the end of follow-up was forced vital capacity (FVC) >10% or diffusing capacity of the lungs for carbon monoxide >15% and radiological progression or death. Cox regression analysis was performed to identify factors associated with worsening of ILD. Results: We included 204 patients with ILD-SAI: 123 (60.3%) had rheumatoid arthritis (RA), 58 had (28.4%) systemic sclerosis, and 23 (11.3%) had inflammatory myopathy. After a median (IQR) period of 56 (29.8–93.3) months, lung disease had stabilized in 98 patients (48%), improved in 33 (16.1%), and worsened in 44 (21.5%). A total of 29 patients (14.2%) died. Progression and hospitalization were more frequent in patients with RA (p = 0.010). The multivariate analysis showed the independent predictors for worsening of ILD-SAI to be RA (HR, 1.9 [95% CI, 1.3–2.7]), usual interstitial pneumonia pattern (HR, 1.7 [95% CI, 1.0–2.9]), FVC (%) (HR, 2.3 [95% CI, 1.4–3.9]), and smoking (HR, 2.7 [95%CI, 1.6–4.7]). Conclusion: Disease stabilizes or improves after a median of 5 years in more than half of patients with ILD-SAI, although more than one-third die. Data on subgroups and risk factors could help us to predict poorer outcomes.
Network-Based Driving Force of National Economic Development: A Social Capital Perspective
Authors: Xing Lizhi , Ai Xi , Ren Jiaqi , Wang Dawei
Published: September 2021

Network science has been widely applied in theoretical and empirical studies of global value chain (GVC), and many related articles have emerged, forming many more mature and complete analytical frameworks. Among them, the GVC accounting method based on complex network theory is different from the mainstream economics in both research angle and content. In this paper, we build up global industrial value chain network (GIVCN) models based on World Input–Output Database, introduce the theoretical framework of Social Capital, and define the network-based indicators with economic meanings. Second, we follow the econometric framework to analyze the hypothesis and test whether it is true. Finally, we study how the three types of capital constituted by these indicators interact with each other, and discuss their impact on the social capital (economic development level, i.e., GDP). The results prove that the structural capital (industrial status) has a positive impact on the social capital; the relational capital (industrial correlation) has a positive impact on both social capital and structural capital; the cognitive capital (industrial structure) has a small impact on the social capital, structural capital, and relational capital.
‘Don’t Say It’s Going to Be Okay’: How International Educators Embrace Transformative Education to Support Their Students Navigating Our Global Climate Emergency
Authors: Jimenez Jeremy , Moorhead Laura
Published: September 2021

Many education professionals are looking to Environmental and Sustainability Education as a guide to incorporate curricular lessons and activities into school classrooms and other learning environments. Building upon the framework of Jickling and Wals (2008) of identifying how to teach about environmental education in transformative ways, this study examined how the experiences and perspectives of seven faculty and staff members at a K-12 International Baccalaureate school in Singapore impacted how they taught about sustainability issues. It also investigated how they work to empower students to become change agents by employing concepts and strategies such as hands-on learning, systems thinking, and service learning. Qualitative interview data revealed four overarching key themes: (1) importance of local context (both the school and the broader socio-political context), (2) pedagogy in relation to student psychology, (3) teacher and staff views on effective pedagogy for teaching about climate crises, and (4) mental health, as experienced by both students and their educators. Teachers and their students regularly struggled with tensions of authority (e.g., school/government, parent/child, teacher/student) and outlook (e.g., “doomism”/hope, empowered/disempowered). Nonetheless, they expressed a variety of thoughtful ways to cultivate their students’ lifelong advocacy for the environment and other related social justice issues.
Cooperative- and Eco-Driving: Impact on Fuel Consumption for Heavy Trucks on Hills
Authors: Hauenstein Juergen , Mertens Jan Cedric , Diermeyer Frank , Zimmermann Andreas
Published: September 2021

Greenhouse gas emissions are the cause of climate change, which in turn has a negative impact on people and the environment. Reducing the fuel consumption of conventional engines reduces climate-damaging emissions and can, thus, contribute to achieving climate protection goals. In addition, fuel costs are a major cost factor for long-haul trucking. Eco-driving helps to reduce fuel costs when driving on inclines and declines. Due to the high mass and, therefore, high kinetic and potential energy of heavy trucks, fuel can be saved by coasting before slopes and before speed limits. However, energy-efficient and non-cooperative driving, i.e., without considering other road users, can lead to increased fuel consumption as vehicles impede each other. To resolve conflicts in road traffic, a variety of methods that enable cooperative driving exist. In general, vehicles communicate with vehicle-to-everything (V2X) and negotiate a joint driving strategy. This paper presents a method that combines cooperative and energy-efficient driving and examines the impact on fuel consumption during uphill driving. The method relies on the exchange of trajectories for cooperative maneuver coordination. By computing a strategic trajectory, energy-efficient driving with long coasting maneuvers is enabled. In the simulative evaluation, travel over hills with two and three trucks is investigated. It is shown that the combination of cooperative and eco-driving reduces the fuel costs for traffic.
Reliable Internet of Things: Challenges and Future Trends
Authors: Khan Mohammad Zubair , Alhazmi Omar H. , Javed Muhammad Awais , Ghandorh Hamza , Aloufi Khalid S.
Published: September 2021

The Internet of Things (IoT) is a vital component of many future industries. By intelligent integration of sensors, wireless communications, computing techniques, and data analytics, IoT can increase productivity and efficiency of industries. Reliability of data transmission is key to realize several applications offered by IoT. In this paper, we present an overview of future IoT applications, and their major communication requirements. We provide a brief survey of recent work in four major areas of reliable IoT including resource allocation, latency management, security, and reliability metrics. Finally, we highlight some of the important challenges for reliable IoT related to machine learning techniques, 6G communications and blockchain based security that need further investigation and discuss related future directions.
Optimization of Action Recognition Model Based on Multi-Task Learning and Boundary Gradient
Authors: Xu Yiming , Zhou Fangjie , Wang Li , Peng Wei , Zhang Kai
Published: September 2021

Recently, people’s demand for action recognition has extended from the initial high classification accuracy to the high accuracy of the temporal action detection. It is challenging to meet the two requirements simultaneously. The key to behavior recognition lies in the quantity and quality of the extracted features. In this paper, a two-stream convolutional network is used. A three-dimensional convolutional neural network (3D-CNN) is used to extract spatiotemporal features from the consecutive frames. A two-dimensional convolutional neural network (2D-CNN) is used to extract spatial features from the key-frames. The integration of the two networks is excellent for improving the model’s accuracy and can complete the task of distinguishing the start–stop frame. In this paper, a multi-scale feature extraction method is presented to extract more abundant feature information. At the same time, a multi-task learning model is introduced. It can further improve the accuracy of classification via sharing the data between multiple tasks. The experimental result shows that the accuracy of the modified model is improved by 10%. Meanwhile, we propose the confidence gradient, which can optimize the distinguishing method of the start–stop frame to improve the temporal action detection accuracy. The experimental result shows that the accuracy has been enhanced by 11%.
A Wide-Band High-Efficiency Hybrid-Feed Antenna Array for mm-Wave Wireless Systems
Authors: Tan Wenhao , Xiao Yu , Li Cong , Zhu Kaiqiang , Luo Hao , Sun Houjun
Published: September 2021

A wide-band and high-efficiency planar antenna array with a novel hybrid-feed structure is proposed in this article. By combing the coaxial-line feed magneto-electric (ME) dipoles with the aperture coupled dielectric cavity, a hybrid-feed 2 × 2-unit ME-dipole sub-array is invented. The low-loss ridge gap waveguide (RGWG) corporate-feed network is used to replace the high-loss substrate-based feed networks and high-cost RWG feed networks. New forms of RGWG H-plane divider are designed to build the RGWG feed network. An 8 × 8-unit ME-dipole antenna array is designed and fabricated to verify the validity of the array. The radiation part consists of two layers of a low-cost printed circuit board (PCB), and the feeding part consists of two copper plates manufactured by computer numerical control (CNC) milling. Measured results show that a relative bandwidth of 16.4% with |S11| < −10 dB is achieved, with a maximum radiation efficiency of 85%. The stable symmetric radiation patterns are observed in both the E-plane and H-plane, covering the operation band. Based on the measured results, a 16 × 16-unit ME-dipole antenna array is simulated. Results indicate that the proposed array has wide-band and high-efficiency features, which is suitable for large-scale array design in mm-wave wireless systems.
A Systematic Assessment of W-Doped CoFeB Single Free Layers for Low Power STT-MRAM Applications
Authors: Rao Siddharth , Couet Sebastien , Van Beek Simon , Kundu Shreya , Sharifi Shamin Houshmand , Jossart Nico , Kar Gouri Sankar
Published: September 2021

Spin-transfer torque magnetoresistive random access memory (STT-MRAM) technology is considered to be the most promising nonvolatile memory (NVM) solution for high-speed and low power applications. Dual MgO-based composite free layers (FL) have driven the development of STT-MRAMs over the past decade, achieving data retention of 10 years at the cost of higher write power consumption. In addition, the need for tunnel magnetoresistance (TMR)-based read schemes limits the flexibility in materials beyond the typical CoFeB/MgO interfaces. In this study, we propose a novel spacerless FL stack comprised of CoFeB alloyed with heavy metals such as tungsten (W) which allows effective modulation of the magnet properties (Ms, Hk) while retaining compatibility with MgO layers. The addition of W results favours a delayed crystallization process, in turn enabling higher thermal budgets up to 180 min at 400 °C. The presence of tungsten reduces the total FL magnetization (Ms) but simultaneously increasing its temperature dependence, thus, enabling a dynamic write current reduction of ~15% at 2 ns pulse widths. Reliable operation is demonstrated with a WER of 1 ppm and endurance >1010 cycles. These results pave the way for alternative designs of STT-MRAMs for low power electronics.
A Review of Hydrogen as a Fuel in Internal Combustion Engines
Authors: Shadidi Behdad , Najafi Gholamhassan , Yusaf Talal
Published: September 2021

The demand for fossil fuels is increasing because of globalization and rising energy demands. As a result, many nations are exploring alternative energy sources, and hydrogen is an efficient and practical alternative fuel. In the transportation industry, the development of hydrogen-powered cars aims to maximize fuel efficiency and significantly reduce exhaust gas emission and concentration. The impact of using hydrogen as a supplementary fuel for spark ignition (SI) and compression ignition (CI) engines on engine performance and gas emissions was investigated in this study. By adding hydrogen as a fuel in internal combustion engines, the torque, power, and brake thermal efficiency of the engines decrease, while their brake-specific fuel consumption increase. This study suggests that using hydrogen will reduce the emissions of CO, UHC, CO2, and soot; however, NOx emission is expected to increase. Due to the reduction of environmental pollutants for most engines and the related environmental benefits, hydrogen fuel is a clean and sustainable energy source, and its use should be expanded.
The Transition to Clean Energy: Are People Living in Island Communities Ready for Smart Grids and Demand Response?
Authors: Abi Ghanem Dana , Crosbie Tracey
Published: September 2021

Islands are widely recognised as ideal pilot sites that can spearhead the transition to clean energy and development towards a sustainable and healthy society. One of the assumptions underpinning this notion is that island communities are more ready to engage with smart grids (SGs) than people on the mainland. This is believed to be due to the high costs of energy on islands and the idea that the sense of community and collective action is stronger on islands than on the mainland. This paper presents findings from a survey conducted to assess people’s perception of, and readiness to engage with, SG and demand response (DR) in the communities of three islands taking part in a H2020 project called REACT. The main objective of the survey, conducted in 2020, was to inform the recruitment of participants in the project, which is piloting different technologies required for SGs and DR with communities on the three islands. The results show that many island residents are motivated to take part in SG, to engage with energy saving, and are willing to change some energy-related behaviours in their homes. However, the results also indicate that levels of ownership of, and knowledge and familiarity with, the SG and DR related technologies are extremely low, suggesting that the expected uptake of DR in islands might not be as high as anticipated. This brings into question the readiness of island dwellers for the SG, their role in the deployment of such schemes more widely and the validity of the assumptions often made about island communities. This has significant implications for the design of SGs and DR solutions for islands, including devoting sufficient efforts to build knowledge and awareness of the SG, investing in demonstration projects for that purpose and tailoring interventions based on island communities’ motivations.
Electromagnetic–Triboelectric Hybridized Nanogenerators
Authors: Xu Lin , Hasan Md Al Mahadi , Wu Heting , Yang Ya
Published: September 2021

Since the triboelectric nanogenerator (TENG) was invented, it has received extensive attention from researchers. Among the many pieces of research based on TENG, the research of hybridized generators is progressing rapidly. In recent years, the research and application of the electromagnetic–triboelectric hybridized nanogenerator (EMG-TENG) have made great progress. This review mainly focuses on the latest research development of EMG-TENG and elaborates on the principles, materials, structure, and applications of EMG-TENG. In this paper, the microscopic charge transfer mechanism of TENG is explained by the most primitive friction electrification phenomenon and electrostatic induction phenomenon. The commonly used materials for fabricating TENG and the selection and modification methods of the materials are introduced. According to the difference in structure, EMG-TENG is divided into two categories: vibratory EMG-TENG and rotating EMG-TENG. The summary explains the application of EMG-TENG, including the energy supply and self-powered system of small electronic devices, EMG-TENG as a sensor, and EMG-TENG in wearable devices. Finally, based on summarizing previous studies, the author puts forward new views on the development direction of EMG-TENG.
Spatial Hurst–Kolmogorov Clustering
Authors: Dimitriadis Panayiotis , Iliopoulou Theano , Sargentis G.-Fivos , Koutsoyiannis Demetris
Published: September 2021

The stochastic analysis in the scale domain (instead of the traditional lag or frequency domains) is introduced as a robust means to identify, model and simulate the Hurst–Kolmogorov (HK) dynamics, ranging from small (fractal) to large scales exhibiting the clustering behavior (else known as the Hurst phenomenon or long-range dependence). The HK clustering is an attribute of a multidimensional (1D, 2D, etc.) spatio-temporal stationary stochastic process with an arbitrary marginal distribution function, and a fractal behavior on small spatio-temporal scales of the dependence structure and a power-type on large scales, yielding a high probability of low- or high-magnitude events to group together in space and time. This behavior is preferably analyzed through the second-order statistics, and in the scale domain, by the stochastic metric of the climacogram, i.e., the variance of the averaged spatio-temporal process vs. spatio-temporal scale.
Effects of Fire Severity and Woody Debris on Tree Regeneration for Exploratory Well Pads in Jack Pine (Pinus banksiana) Forests
Authors: Filicetti Angelo T. , LaPointe Ryan A. , Nielsen Scott E.
Published: September 2021

Restoring anthropogenic footprints to pre-disturbance conditions or minimizing their long-term impacts is an important goal in conservation. Many footprints, particularly if left alone, have wide-ranging effects on biodiversity. In Canada, energy exploration footprints result in forest dissection and fragmentation contributing to declines in woodland caribou. Developing cost effective strategies to restore forests and thus conserving the woodland caribou habitat is a conservation priority. In this study, we compared the effects of wildfire and local variation in the amount of residual woody debris on natural regeneration in jack pine on exploratory well pads in Alberta’s boreal forest. Specifically, we investigated how footprint size, fire severity (overstory tree mortality), ground cover of fine and coarse woody debris, and adjacent stand characteristics (i.e., height, age, and cover), affected tree regeneration densities and height using negative binomial count and linear models (Gaussian), respectively. Regeneration density was 30% higher on exploratory well pads than adjacent forests, increased linearly with fire severity on the exploratory well pads (2.2% per 1% increase in fire severity), but non-linearly in adjacent forests (peaking at 51,000 stems/ha at 72% fire severity), and decreased with amount of woody debris on exploratory well pads (2.7% per 1% increase in woody debris cover). The height of regenerating trees on exploratory well pads decreased with fire severity (0.56 cm per 1% increase in fire severity) and was non-linearly related to coarse woody debris (peaking at 286 cm at 9.4% coarse woody debris cover). Heights of 3 and 5 m on exploratory well pads were predicted by 13- and 21-years post-fire, respectively. Our results demonstrate that wildfires can stimulate natural recovery of fire-adapted species, such as jack pine, on disturbances as large as exploratory well pads (500–1330 m2) and that the type and amount of woody debris affects these patterns.
The Value of Hybrid Aspen Coppice Investment under Different Discount Rate, Price and Management Scenarios: A Case Study of Estonia
Authors: Hepner Heiki , Lukason Oliver , Lutter Reimo , Padari Allar , Tullus Arvo , Tullus Hardi
Published: September 2021

Hybrid aspen is one of the most promising tree species for short-rotation forestry in Northern Europe. After the clearcutting of hybrid aspen plantation, the next generation arises from root and stump sprouts. The economic feasibility of different management strategies of hybrid aspen coppice stands has not yet been comprehensively evaluated in Northern Europe. We compared the land expectation values (LEVs) of hybrid aspen coppice stands managed according to four scenarios: three early thinning methods (corridor, cross-corridor and single-tree) followed by conventional management and intensive bioenergy production (repeated harvests in 5-year rotations) over a 25-year period in hemiboreal Estonia. We considered the historic price volatility of aspen wood assortments under various discount rates (1–20%). We found that the 25-year rotation with different early thinning methods was more profitable than short bioenergy cycles in the case of low discount rates (<5%). The LEV of short coppice cycles for only bioenergy production became more profitable in comparison with those by thinning methods, when higher discount rates (>10%) were applied. Hybrid aspen coppice stands can be managed profitably, but more risks are taken when the management strategy focuses only on bioenergy production.