bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación del comportamiento de la demanda en el modelado de las redes de distribución
Authors: Solis-Ortega Rebeca , Gómez Ramírez Gustavo Adolfo , Sáenz-González Kervyn Josué , Ellis-Rodríguez Alfredo Josué , Navarro-Alpízar William Johan
Published: December 2024

Las compañías eléctricas buscan desarrollar una infraestructura eléctrica de transmisión y distribución confiable para satisfacer las necesidades energéticas de los consumidores. La flexibilidad, la resiliencia y la seguridad de las redes a menudo pueden mejorarse mediante la presencia de una infraestructura eléctrica robusta. Debido a la falta de planificación, muchas veces no se invierte en los proyectos eléctricos necesarios, lo que podría provocar su aplazamiento en determinadas situaciones y comprometer la confiabilidad del sistema. Para realizar una buena gestión del sistema de potencia, se requiere tener datos tanto de la generación, respuesta de la demanda y todo lo necesario para realizar una adecuada planificación. Utilizando la información recopilada de medidores inteligentes y mediciones de redes de distribución, en este artículo se simulará y comparará el modelado de respuesta de la demanda. Modelamos una red de distribución residencial con 634 cargas residenciales utilizando el Programa Analizador de Transitorios Eléctricos (ETAP®) para determinar los efectos en el rendimiento de la red de distribución. Los resultados de la simulación sugieren que simulando la respuesta de la demanda utilizando datos de medidores inteligentes o mediciones del circuito de distribución se pueden lograr variaciones de hasta 13,06%. Además, en ambas situaciones se podrían conseguir distintos perfiles de tensión lo cual en la planificación de las redes eléctricas se puede comprometer las decisiones que puedan ser tomadas al respecto.
Diseño y construcción de un túnel de viento subsónico de circuito abierto
Authors: Garro-Fernández Fiorella , Echandi-Jara Carlos Alberto , Fallas-Hernández Emanuel , Zúñiga-Pepper Marco , Richmond-Navarro Gustavo
Published: December 2024

El Laboratorio de Investigación en Energía Eólica del Instituto Tecnológico de Costa Rica (LIENE) ha diseñado y construido un túnel de viento subsónico de circuito abierto que funciona por succión, con una sección de pruebas 30 x 30 cm, donde se puede caracterizar el comportamiento aerodinámico de modelos en un flujo de aire controlado. El túnel funciona con un motor de 1 caballo de fuerza y puede operar a velocidades de viento entre 7 y 15 m/s; la instrumentación instalada actualmente permite medir fuerzas de sustentación de hasta 100 N y de arrastre de hasta 50 N. En el siguiente trabajo se describe el procedimiento de la concepción, fabricación, instrumentación y caracterización del túnel, desde su base teórica hasta su diseño y operación.
AПОФАТИЗАМ И ТОПОС НЕИЗРЕЦИВОСТИ У ВЛАДАРСКИМ ЖИТИЈИМА ДАНИЛА ДРУГОГ
Authors: Половина Наташа
Published: December 2024

Данило Други сматра се правим представником исихазма у српској средњовековнојкњижевности. Међу бројним елементима исихастичке традиције препознатим упрози овог писца (Животи краљева и архиепископа српских), најмање научне пажњепосвећено је апофатизму и вези овог појма с топосом неизрецивости. Појмовиапофатизам и топос неизрецивости у раду се употребљавају у контексту начелаграђења књижевног дела, и то пре свега с обзиром на њихово место у композицијипојединачних житија.
ЗНАЧЕЊСКИ ОДНОСИ ИЗМЕЂУ ТРИ ПРАСЛОВЕНСКА ТЕРМИНА ЗА ЗАКЛЕТВУ У СЛОВЕНАЧКОМ И РУСКОМ ЈЕЗИКУ ДО XVII ВЕКА
Authors: Манојловић Соња
Published: December 2024

У раду се одређује значењски однос између три прасловенска термина за заклетву (*rota, *prisęga и *klętva) и заклињање (*rotiti (se), *prisęgati и *klęti (se)), а затим се њихов развој прати у словеначком и руском језику до XVII века, на основу писаних споменика ова два језика. Значења се утврђују на основу контекста. Циљ је утврдити да ли је постојала разлика у њиховом значењу или се радило о синонимима, као и како су се значења даље развијала. Бележе се и конструкције у којима се ови термини употребљавају.
РАЗВОЈ ТЕОРИЈСКО-МЕТОДОЛОШКИХ КОНЦЕПАТА РЕКЦИЈЕ И ВАЛЕНТНОСТИ У СРПСКОЈ ЛИНГВИСТИЦИ
Authors: Драгић Мила
Published: December 2024

У овом раду приказан је преглед развоја теоријско-методолошких концепата рекције и валентности у српској лингвистичкој литератури. У обзир су узети радови, граматике и студије писане на српском језику, који за предмет имају српски језички материјал, а које су писали домаћи аутори. Приказана литера- тура обухвата период од половине прошлог века па до данас. Примећено је да се у тумачењу појава везаних за глаголску рекцију, валенцију и проблем допуњавања издвајају два различита приступа у којима се појмови валенције и рекције различито дефинишу. За оба становишта је карактеристично истицање проблема у разликовању допуна и одредаба (односно додатака). Циљ рада је био да се прегледом ове литературе покаже како су се схватања о рекцији и валент- ности као феноменима развијала у нашој науци о језику и које су то релевантне теме и аутори који су се њима бавили.
ANALISIS PREFERENSI DAN KEPUASAN KONSUMEN TERHADAP PRODUK SIRUP BUNGA MAWAR (Studi Kasus di UMKM Widoro Asih Kabupaten Nganjuk)
Authors: Rusdianto Andrew Setiawan , Mahardika Nidya Shara , Kusumawardani Septianing Tyas
Published: December 2024

Bunga mawar memiliki kandungan antioksidan yang dapat menangkal radikal bebas, sehingga bunga mawar dapat dimanfaatkan sebagai produk pangan seperti sirup. Sirup pada dasarnya memiliki rasa manis atau asam, akan tetapi sirup bunga mawar memiliki rasa yang ciri khas yaitu sepat manis. Penelitian ini dilakukan untuk mengetahui preferensi dan kepuasan konsumen terhadap produk sirup bunga mawar UMKM Widoro Asih. Tujuan dari penelitian ini adalah untuk mengetahui kombinasi atribut sirup bunga mawar, kepuasan konsumen terhadap sirup bunga mawar dan rekomendasi perbaikan sirup bunga mawar berdasarkan kombinasi atribut. Responden dalam penelitian ini diambil dengan teknik purposive sampling sebanyak 80 responden dan pengumpulan data dilakukan pada bulan Maret sampai dengan Mei 2024. Metode analisis yang digunakan adalah analisis conjoint dan Customer Satisfaction Indeks (CSI). Hasil penelitian menunjukkan bahwa konsumen sirup bunga mawar sebagian besar berjenis kelamin perempuan dengan rentang usia 35-40 tahun dan bekerja sebagai ibu rumah tangga. Kombinasi atribut sirup bunga mawar yang menjadi kesukaan konsumen adalah rasa sepat manis, warna merah muda, aroma dominan lemon, kekentalan encer, harga Rp. 15.000-20.000, ukuran kemasan 250 ml, dan jenis kemasan botol kaca. Tingkat kepentingan atribut berdasarakan preferensi konsumen, terdapat 3 atribut yanag memiliki nilai kepentingan tertinggi yaitu atribut rasa, aroma dan juga kekentalan. Tingkat kepuasan konsumen diperoleh sebesar 73,86% dengan kategori puas. Rekomendasi perbaikan yang diberikan untuk sirup bunga mawar UMKM Widoro Asih adalah mengurangi komposisi ekstrak bunga mawar dan menganti kemasan botol plastik dengan kemasan botol kaca.
ANALISIS PENERAPAN GOOD MANUFACTURING PRACTICE (GMP) PADA PROSES PRODUKSI ROTI GEMBONG
Authors: Kuswardhani Nita , Mahardika Nidya Shara , Salsabila Adine Rara
Published: December 2024

Perkembangan industri di Indonesia terus meningkat seiring dengan teknologi dan sistem produksi yang menunjang industri saat ini. Roti Gembong Hamasah merupakan salah satu perusahaan perseorangan yang bergerak di bidang pangan yaitu Roti Gembong. Evaluasi GMP mencakup 18 aspek seperti lokasi, bangunan, sanitasi, mesin, bahan, pengendalian proses, produk akhir, laboratorium, karyawan, pengemasan, label, penyimpanan, pemeliharaan, transportasi, dokumentasi, pelatihan, penarikan produk, dan penerapan pedoman. Analisis kesenjangan dengan metode gap analysis menunjukkan skor penerapan GMP sebesar 73,33%. Dari 18 aspek dengan 150 subaspek tidak ada yang mendapat nilai 0, 7 aspek mendapat nilai 1, 12 aspek mendapat nilai 2, 83 aspek mendapat nilai 3, dan 48 aspek mendapat nilai 4. Faktor penyebab penyimpangan GMP dengan diagram fishbone diperoleh 2 faktor penyebab dari kategori metode (SOP dan pengawasan proses), 2 faktor penyebab dari kategori lingkungan (kebersihan dan lokasi), 1 faktor penyebab dari kategori manusia (karyawan), dan 2 faktor penyebab dari kategori material (kualitas bahan dan komposisi bahan). Terdapat 102 parameter dengan skor 0-3 sehingga menghasilkan 41 rekomendasi. Perspektif pertama dengan 41 rekomendasi memperkirakan biaya sebesar Rp4.568.000 untuk mencapai 100% penerapan GMP, sedangkan perspektif kedua dengan 28 rekomendasi tanpa biaya meningkatkan penerapan GMP menjadi 91,1%.
ANALISIS PERSEDIAAN BAHAN BAKU TEPUNG TERIGU DENGAN MENGGUNAKAN METODE ECONOMIC ORDER QUANTITY (Studi Kasus di UD. Elza Putra Food)
Authors: Kuswardhani Nita , Sapta Muhammad Sadam Putra , Choiron Miftahul
Published: December 2024

Tujuan penelitian dilakukan untuk mengetahui hasil perbandingan pengendalian persediaan bahan baku tepung terigu menggunakan metode Economic Order Quantity (EOQ) dan metode konvensional, mengetahui reorder point dan safety stock bahan baku tepung terigu pada UD. Elza Putra Food, dan mengetahui perbedaan biaya persediaan bahan baku tepung terigu sebelum dan sesudah menggunakan metode Economic Order Quantity (EOQ) pada UD. Elza Putra Food.  Pengendalian bahan baku masih menggunakan sistem konvensional berdasarkan pesanan sebelumnya dan jumlah stok bahan baku menjadi permasalahan UD. Elza Putra Food sehingga berisiko kehabisan stok. Penelitian ini dilakukan melalui beberapa tahapan penelitian meliputi studi lapangan, studi pustaka, identifikasi masalah, simpulan dan saran serta dianalisis menggunakan metode Economic Order Quantity (EOQ). Penerapan metode EOQ total biaya persediaan dapat diminimumkan sebesar Rp. 401.733, jumlah pemesanan lebih banyak 118 zak dengan frekuensi pemesanan 14 kali, persediaan pengaman sebanyak 28 zak dan titik pemesanan ulang saat bahan baku tersisa 41 zak. Sedangkan metode konvensional mengeluarkan total biaya sebesar Rp. 1.340.161, jumlah pemesanan sebanyak 36 zak dengan frekuensi pemesanan 48 kali, dan titik pemesanan ulang saat bahan baku tersisa 10 zak tanpa persediaan pengaman. Hasil perbandingan menunjukkan bahwa penerapan EOQ jumlah pemesanan lebih banyak 82 zak, persediaan pengaman sebanyak 28 zak, titik pemesanan ulang sebanyak 31 zak, dan frekuensi pemesanan lebih sedikit 34 kali.
ANALISIS KEPUASAN KONSUMEN ROTI AMIRAH BAKERY DI KABUPATEN TULUNGAGUNG
Authors: Hapsari Shinta Syafrina Endah , Amilia Winda , Wiyono Andi Eko , Zuhriyah Anis K
Published: December 2024

Semakin pesatnya persaingan usaha pada perusahaan roti menjadikan perusahaan dituntut untuk terus meningkatkan mutu/kualitas produknya. Amirah Bakery merupakan salah satu industri roti yang hingga kini masih berdiri di Kabupaten Tulungagung dan konsisten melakukan pengembangan terhadap bisnisnya dengan mengedepankan kepuasan pelanggan sebagai prioritas utamanya. Penelitian ini  diharapkan dapat menjawab tingkat kepuasan konsumen roti Amirah Bakery; prioritas atribut produk dan layanan Amirah Bakery; dan rekomendasi perbaikan yang dapat implementasikan di Amirah Bakery untuk menunjang keberlanjutan bisnisnya. Metode yang digunakan dalam penelitian ini yaitu CSI (Customer Satisfaction Index), dan Importance Performance Analysis (IPA). Alat penelitian yang digunakan berupa kuesioner, dan hasil penelitian menunjukkan bahwa pelanggan sangat puas dengan kualitas roti Amirah Bakery dengan nilai CSI sebesar 81,73%, dan perbaikan yang harus diutamakan berdasarkan Importance Performance Analysis adalah atribut 9, 10 dan 20, yaitu kemasan roti, warna roti dan performa pelayanan karyawan toko. Adapun rekomendasi perbaikan yang dapat dilakukan antara lain: mendesain ulang kemasan, mengembangkan inovasi produk, dan perlu adanya himbauan kepada karyawan untuk memahami perilaku yang ideal dalam bekerja.
Familias monoparentales y permiso por nacimiento y por cuidado de hijo o menor. Oportunidad de los pronunciamientos de las dos Salas del Tribunal Supremo
Authors: García Gil Begoña
Published: December 2024

Estudio y análisis comparativo de los argumentos jurídicos que las Sala de lo Social y la Sala de lo Contencioso Administrativo del Tribunal Supremo han utilizado para dictar sentencias contrarias respecto del permiso por nacimiento o por cuidado de hijo menor en el caso de familias monoparentales. A los efectos de la posible acumulación en el progenitor del permiso del otro progenitorsi existiera como sucede en las familias biparentales.
Türk Edebiyatının Cezayir Şiiri ve Toplumsal Yapıya Etkisi: Dilbilimsel ve Estetik Süreklilik
Authors: Dursun Hüseyin
Published: December 2024

Türk edebiyatının Cezayir şiiri üzerindeki etkisi, toplumsal yapı ile dilbilimsel devamlılık bağlamında önemli bir konu olarak öne çıkmaktadır. Bu çalışma, Osmanlı döneminde Cezayir şiirinin estetik özelliklerini ve toplumsal yansımalarını inceleyerek, iki edebiyat arasındaki dil ve üslup etkileşimini detaylı bir şekilde analiz etmektedir. Osmanlı sanatının ve kültürel mirasının Cezayir şiirine yaptığı katkılar, şiirlerdeki toplumsal ve siyasi temalar üzerinden değerlendirilmektedir. Cezayirli ve Osmanlı şairlerinden verilen örneklerle bu etkilerin şiir dili üzerindeki yansımaları incelenmiştir. Osmanlı dönemi Cezayir şiiri, toplumsal olaylar ve değişimlerle sıkı bir ilişki içindedir. Şairler, dönemin siyasi ve toplumsal atmosferine tepkilerini şiirleriyle yansıtmışlar, bu durum şiirin toplumsal yapıyı şekillendiren bir araç olarak kullanılmasına olanak sağlamıştır. Ayrıca, şiirlerdeki Dinî motifler ve estetik yaklaşımlar da Osmanlı etkisinin belirgin bir parçası olmuştur. Cezayir şiirinin, Osmanlı'dan devralınan bu mirası modern dönemde de sürdürebildiği ve dil ile üslup açısından Osmanlı şiirine benzerlikler taşıdığı gözlemlenmektedir. Günümüz açısından bu çalışma, Osmanlı-Cezayir şiir ilişkisinin modern edebiyat üzerindeki etkilerini ve bu mirasın güncel dilbilimsel ve toplumsal analizlere katkılarını irdelemektedir. Araştırma, Cezayir şiirinin dilsel ve kültürel devamlılık bağlamında Osmanlı dönemindeki etkilerini nasıl sürdürdüğünü ve modern toplumsal yapı üzerindeki yansımalarını somut örneklerle açıklamaktadır. Bulgular, Edebî mirasın toplumsal ve kültürel sürekliliği sağlama potansiyelini ortaya koyarak modern edebiyat analizlerine önemli bir katkı sunmaktadır.
The aging heart: exploring the role of Klotho in cardiac health/function
Authors: Daneshgar Nastaran , Dai Dao-Fu , Grueter Chad E.
Published: December 2024

This review discusses the pathophysiological changes associated with cardiac aging and the potential therapeutic role of the anti-aging protein Klotho. It highlights key contributors to heart failure, such as arterial stiffening, myocardial fibrosis, and impaired cardiac relaxation, all of which lead to the declining function of the aging heart. This review also explores the regulation of Klotho expression, its various forms, and its impact on cardiac health, emphasizing its protective roles against oxidative stress, inflammation, and cardiac remodeling. Klotho's potential as a therapeutic target for mitigating cardiac aging and improving cardiovascular health in the elderly is a central theme, making it a promising candidate for future interventions aimed at enhancing cardiac function and longevity.
Dissonance, Sound Spectrum and Musical Scale for Ancient Idiophones and Aerophones
Authors: Etxebarria Victor
Published: December 2024

We do not know how the earliest musical instruments -such as idiophones and aerophones- were played, but their acoustic properties can provide valuable clues. As a first step, we present here dissonance curves for a sound of a given spectrum. These curves show the relative dissonance that results for all intervals of a given instrument. This then leads to the association of spectra and scales, which are related because the dissonance curve has minima in the intervals that define the scale. A computational method for calculating dissonance curves is presented and several examples of its use in practical cases, both for Western and Eastern musical instruments, are given and interpreted. These results allow us to explain from a physical point of view the existence of well-known modern twelve note scales, as well as some uncommon but documented scales for various instruments in early musical history.
Novel Oro-Nasal Drainage for Long COVID: Proposed Mechanisms – Case Report
Authors: Lorenz Claudia , Frankenberger Roland
Published: December 2024

Long COVID, potentially emerging post COVID-19 infection, involves extreme health challenges. Based on the current literature in the field, we propose a novel approach to Long COVID treatment based on epipharyngeal abrasive therapy targeting ostia of the oral and nasal mucosa, having been identified for the first time. The presented case report documents the application of innovative Oro-nasal Drainage (OND), a novel treatment integrating physiological, biochemical, and fluid mechanical components simultaneously. OND led to remarkable improvements and even remissions of various symptoms, along with enhanced hand blood circulation. While the case suggests a potential in Long COVID therapy, it is crucial to acknowledge inherent limitations.
Universal Relations for Non-Rotating Objects Made of Dark Energy
Authors: Panotopoulos Grigorios
Published: December 2024

We obtain universal relations for fluid spheres without rotation made of dark energy assuming the Extended-Chaplygin Gas equation-of-state. After integrating the relevant differential equations, we make a fit to obtain the unknown coefficients of the functions a) normalized moment of inertia versus dimensionless deformability and b) normalized moment of inertia versus factor of compactness. We find that the form of the functions does not depend on the details of the underlying equation-of-state.
Improved Confidence Intervals for Expectiles
Authors: Maesono Yoshihiko , Penev Spiridon
Published: December 2024

This paper is concerned with the derivation of the Edgeworth expansion for the standardized and the studentized version of the kernel-based estimator of the expectile. Inverting the expansion allows us to construct accurate confidence intervals for the expectile. The theoretical asymptotic results are applied for moderate sample sizes. The methodology is illustrated with an application in risk management in finance for the estimation and accurate confidence interval construction for the coherent risk measure expectile-VaR.
Effects of Digestive Enzyme Tuna Hydrolysate on Expression of Longevity Gene-Related Nad-Dependent Sirtuin Protein, Mitochondrial Activity, and Antioxidant Capacity in Peripheral Blood Mononuclear Cells In Vitro
Authors: Sugishita Yodo , Suzuki-Takahashi Yuki , Yudoh Kazuo
Published: December 2024

The longevity gene-associated protein sirtuin, which has NAD-dependent deacetylation enzyme activity, plays an important role in genomic stability, antioxidant potential, DNA repair, mitochondrial and energy metabolism all of which are associated with a healthy state. NAD+ and sirtuin levels can be increased by supplementing with NAD precursors including nicotinamide mononucleotide (NMN) and some polyphenols. If meals contain NAD precursors and NAD synthesis activators, a daily diet, as well as NMN supplements, may support NAD+ augmentation and the resultant sirtuin activation. This can then lead to a resulting improvement in mitochondrial metabolism and health. Because tuna meat contains NAD precursors, we postulate that a daily diet of fish has the potential to increase the levels of sirtuins which are NAD-dependent regulators of mitochondria in human cells.
In the present study, we investigated whether tuna meat regulates mitochondrial function and energy metabolism in human peripheral blood mononuclear cells (PBMCs). A digestive enzyme tuna meat hydrolysate was prepared from tuna dark red meat. Mitochondrial activity (NAD+/NADH level), sirtuin expression, energy production (ATP level) and antioxidant activity in PBMCs were analyzed after the treatment of cells with the digestive enzyme tuna hydrolysate or controls in vitro. Our results demonstrate that the digestive enzyme tuna hydrolysate has the potential to increase the expression of longevity gene-related proteins sirtuin 1 and 2, NAD+/NADH levels, and ATP production by mitochondria in PBMCs. Furthermore, tuna meat showed high antioxidant capacity in vitro. These findings indicate the favorable effect of tuna meat on mitochondrial function and homeostasis. Our study underscores the benefits of tuna meat as a dietary choice and provides scientific support for promotion of healthy aging.
The Generalized Characteristic Polynomial of the $K_{m, n}$-Complement of a Bipartite Graph
Authors: Zhao Weiliang , Gong Helin
Published: December 2024

The generalized matrix of a graph $G$ is defined as $M(G)=A(G)-tD(G)$ ($t \in \mathbb{R}$, $A(G)$ and $D(G)$ respectively denote the adjacency matrix and the degree matrix of $G$), and the generalized characteristic polynomial of $G$ is merely the characteristic polynomial of $M(G)$. Let $K_{m,n}$ be the complete bipartite graph. Then the $K_{m,n}$-complement of a subgraph $G$ in $K_{m,n}$ is defined as the graph obtained by removing all edges of an isomorphic copy of $G$ from $K_{m,n}$. In this paper, by using a determinant expansion on the sum of two matrices (one of which is a diagonal matrix), a general method for computing the generalized characteristic polynomial of the $K_{m,n}$-complement of a bipartite subgraph $G$ was provided. Furthermore, when $G$ is the $k$ edge-disjoint union or a graph with rank no more than 4, the explicit formula for the generalized characteristic polynomial of the $K_{m,n}$-complements of $G$ is given.
Altered Expression Levels of Angiogenic Peptides in the Carotid Body of Spontaneously Hypertensive Rats
Authors: Atanasova Dimitrinka Y. , Rashev Pavel I. , Mourdjeva Milena S. , Pupaki Despina V. , Hristova Anita , Dandov Angel D. , Lazarov Nikolai E.
Published: December 2024

The carotid body (CB), the main peripheral arterial chemoreceptor, exhibits considerable structural and neurochemical plasticity in response to pathological conditions such as high blood pressure. Previous studies have shown that morphological alterations in the hypertensive CB are characterized by enlarged parenchyma due to cellular hypertrophy and hyperplasia, and vasodilation. To test whether hypertension can also induce neoangiogenesis and modulate its chemosensory function, we examined the immunohistochemical expression of two angiogenic factors, vascular endothelial growth factor (VEGF) and endothelin-1 (ET), and their corresponding receptors in the CB of adult spontaneously hypertensive rats (SHRs), and compared their expression patterns to that of age-matched normotensive Wistar rats (NWR). We found an increased VEGF-A and B, and VEGFR-2 expression in glomus and endothelial cells in the enlarged CB glomeruli of SHRs compared with that in NWR. Conversely, weaker immunoreactivity to VEGFR-1 was detected in cell clusters of the hypertensive CB. The expression of endothelin-converting enzyme 1 and its receptor ETA was higher in a subset of glomus cells in the normotensive CB, while the immunoreactivity to the ETB receptor was enhanced in endothelial cells of CB blood vessels in SHRs. The elevated endothelial expression of VEGF and ET-1 suggests their role as local vascular remodeling factors in the adaptation to hypertension though their involvement in the cellular rearrangement and modulation of chemosensory function could also be implied.
β-Lactam/β-Lactamase Inhibitor Combination Antibiotics Under Development
Authors: Katsarou Angeliki , Stathopoulos Panagiotis , Tzvetanova Iva D. , Asimotou Christina Maria , Falagas Matthew E.
Published: December 2024

Antimicrobial resistance remains a public health problem of global concern with a great health and financial burden. Its recognition as a threat by political leadership has boosted the research and development of new antibiotics and particularly novel combinations of β-lactams/β-lactamase inhibitors against multidrug-resistant (MDR) Gram-negative pathogens which remain the major concern in clinical practice. The incorporation of ceftolozane/tazobactam, ceftazidime/avibactam, meropenem/vaborbactam, and imipenem/cilastatin/relebactam has provided new therapeutic options in the treatment of patients with infections due to MDR pathogens. Cefiderocol along with cefepime/enmetazobactam, avibactam/aztreonam, and sulbactam/durlobactam have been recently added to these agents as therapeutic choices, particularly for metallo-β-lactamase producing Gram-negative bacteria. Currently, many combinations are being studied for their in vitro activity against both serine- and metallo-β-lactamases. However, only a few have advanced through phase 1, 2, and 3 clinical trials. Among them, in this article, we focus on the most promising combinations of cefepime/zidebactam, cefepime/taniborbactam, and imipenem/cilastatin/funobactam, which are currently under investigation in phase 3 trials.
Different Oral Appliance Therapy Device Designs are Associated with Significantly Different Efficacy for the Treatment of Obstructive Sleep Apnea: A Review Article
Authors: Liptak Leonard , Sall Edward , Kim Sung , Mosca Erin , Charkhandeh Shouresh , Remmers John E
Published: December 2024

Obstructive Sleep Apnea is a highly prevalent disease effecting and estimated 1 billion people worldwide. Untreated, Obstructive Sleep Apnea is associated with elevated levels of mortality, decreased quality of life and increased economic costs. However, the strong efficacy of Continuous Positive Airway Pressure therapy, the most frequently prescribed treatment for Obstructive Sleep Apnea, is compromised by frequent refusal and termination rates. As a result, healthcare providers are evaluating non-CPAP treatment options for patients who terminate or refuse Continuous Positive Airway Pressure therapy. Oral Appliance Therapy devices have emerged as a leading alternative. With dozens of Oral Appliance Therapy devices available to healthcare providers, this review investigates whether different Oral Appliance Therapy device designs matter; are different Oral Appliance device designs associated with different levels of efficacy? This review evaluated 149 different source papers investigating the efficacy of Oral Appliance Therapy, yielding 39 unique papers that met the inclusion criteria, encompassing a pooled sample of 3,799 patients treated with six distinctly different Oral Appliance Therapy device designs. Chi-squared and two-sided Fisher’s exact tests revealed significant differences. As a result, healthcare providers and medical guidelines should consider Oral Appliance Therapy device designs when prescribing Oral Appliance Therapy for the treatment of Obstructive Sleep Apnea.
The Role of Place Attachment in the Impact of Urban Parks on Young Adults’ Perceived Restoration, A Case Study of Xiamen, China
Authors: Yi Chen Rong , Zi Ma Tian , Guo Lin Zhen , Hui Pan
Published: December 2024

Most existing studies primarily examine the relationship between urban parks and individuals’ perceived restoration, with limited focus on the role of place attachment formed through interactions with urban parks. This research investigates the role of place attachment in the relationship between urban parks and young adults' perceived restoration. Using Zhongshan Park in Xiamen, China, as a case study, 312 valid questionnaires were collected and analyzed through a Structural Equation Model (SEM). The findings reveal that urban parks—categorized as natural elements, perceptual elements, rest elements, and activity elements—have a direct and significant positive influence on young adults' perceived restoration, with activity elements exhibiting the strongest effect. Additionally, most urban park elements significantly and positively impact place attachment, defined by place dependence and place identity. However, perceptual elements did not significantly influence place dependence, and rest elements did not significantly impact place identity. Notably, the study revealed that young adults' perceived restoration in urban parks can be indirectly influenced through two distinct pathways: place dependence and place identity. These insights provide a theoretical foundation for urban planners to design restorative parks effectively.
Comparative Study of Anesthetic and Post Operative Complications in Trauma Patients: (Intoxicated vs Non‐Intoxicated with Alcohol)
Authors: Vangalapati Navya , Jadhav Monika Vedraj
Published: December 2024

Alcohol is a substantial risk factor for trauma, accounting for 30-50% of cases with alcohol intoxication. Alcohol usage impairs wound healing in traumatic injuries by lowering immune function and leukocyte production. This review compares the outcomes and complications of trauma patients who have consumed alcohol to those who have not. Systematic and independent searches were carried out on PubMed, Google Scholar, Scopus, and Web of Science databases. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were strictly followed. Data was gathered on the type of trauma, the type of operation, whether or not alcohol was used, the outcomes, and the complications. The study included 12 publications, all of which came to the same conclusion: trauma patients with alcohol intoxication spent more time on mechanical ventilators, had longer Intensive care unit, Length of stay, and had longer hospital stays.
NON-TUBERCULOSIS MYCOBACTERIA SPECIES CIRCULATING IN THE SIBERIAN FEDERAL DISTRICT OF RUSSIA
Authors:   Novosibirsk Tuberculosis Research Institute, TURSUNOVA NATALYA V. , GUSELNIKOVA ELENA P. ,   Novosibirsk Tuberculosis Research Institute, GORDEEVA ELIZAVETA I. ,   Novosibirsk Tuberculosis Research Institute
Published: December 2024

Introduction. Non-tuberculous mycobacteria are ubiquitous; they are widespread in soil and water, including
plumbing, aquariums, hot water supply systems, and air conditioning systems. Currently, more than 200 species of
non-tuberculous mycobacteria are known, of which about 60 species have proven clinical significance, the rest are
widespread in the environment, and little is known about their ability to cause diseases. Aim. The purpose of this study
was to investigate the species diversity of non-tuberculous mycobacteria circulating in the Siberian Federal District
of Russia. Materials and Methods. Two typical regions of the Siberian Federal District were selected for the study: Novosibirsk and Tomsk regions. Mycobacteria were cultured from patients’ sputum samples: 45 samples from the State
Regional Clinical Tuberculosis Hospital and 106 from the Regional Department of Tomsk Phthisiopulmonology Medical
Center. Further, non-tuberculous mycobacteria were identified by species, using the time-of-flight mass-spectrometry
and the extraction with formic acid on an instrument according to the study protocol. Statistical processing of the
study results was carried out using Microsoft Excel 2016 computer programs for Windows. Extensive indicators (the
percentage of patients with detected pathogen drug resistance to the total number of patients, whose material was
tested) were also calculated, and the boundaries of 95% confidence intervals (95% CI) were defined for the proportion
(Fisher’s method). Statistical calculation of the research results was carried out in Microsoft Excel 2016. Results and
Discussion. Among the slow-growing non-tuberculous mycobacteria species, Mycobacterium Avium complex is most
common. Mycobacterium simie complex, Mycobacterium lentiflavum, and Mycobacterium parascorfulaceum were
found less frequently. There were also Mycobacterium terrae complex and Mycobacterium nonchromogenicum found.
The slow-growing mycobacteria, currently not grouped into a complex, include Mycobacterium Mycobacterium szulgae
and Mycobacterium gordonae. Mycobacterium abscessus / Mycobacterium chelonae complex dominated among the
fast-growing mycobacteria species. Mycobacterium fortuitum complex was a less common complex. Conclusions.
For the first time, diversity was assessed and the dominant strains of mycobacteria circulating in the Novosibirsk and
Tomsk regions were identified, which gives an idea of the main target strains, at which the main preventive and sanitizing
measures should be targeted
CLINICAL SIGNIFICANCE OF A HISTOPATHOLOGICAL EXAMINATION IN THE DIFFERENTIAL DIAGNOSIS OF DISSEMINATED PROCESSES IN LUNGS
Authors:   Novosibirsk Tuberculosis Research Institute, MENTYUKOVA-SUZDALTSEVA IRINA YU. , TURSUNOVA NATALYA V. ,   Novosibirsk Tuberculosis Research Institute
Published: December 2024

Introduction. Disseminated processes in the lungs include more than two hundred diseases and syndromes,
similar in clinical, radiological and laboratory manifestations, which is the main reason for the difficulty of differential
diagnosis. In most cases, histopathological examination plays a key role in making the correct diagnosis. Aim is to
analyze the current state of the problem of diagnosing disseminated processes in lungs exemplified by the experience
of an anti-tuberculosis hospital and assess the algorithm for the differential diagnosis of pulmonary dissemination
using histological methods. Materials and Methods. Histopathological findings (156 clinical cases) were obtained
at Novosibirsk Tuberculosis Research Institute for the period of 2022-2023. The diagnostic material was biopsy tis-
sue samples. Sections were stained with hematoxylin-eosin by the methods of Van Gieson or Weigert-Van Gieson,
Ziehl-Neelsen, Grocott, and Perls. Results and Discussion. The study presents an analysis of cases of differential
diagnosis of disseminated lung diseases of unknown etiology and provides the clinical examples of histopathological
examination of biopsy material from hospital inpatients. Most often, in the presence of granulomatous processes, the
preliminary diagnosis of pulmonary tuberculosis was confirmed. The second place in frequency was taken by chronic
nonspecific pulmonary diseases (about ¼ of the total number of patients, which can be explained by their significant
prevalence among the population). Chronic infections of fungal etiology were found in the samples, especially in immu-
nosuppressed individuals. Conclusions. Diagnosis of disseminated processes in the lungs using analysis of histologi-
cal material obtained through transbronchial lung biopsy, diagnostic thoracotomy, mediastinoscopy, or video-assisted thoracoscopy is the most accurate and allows the medical professional to quickly identify the nature of dissemination.
The main morphological assessing algorithm includes the identification of inflammation and the subsequent clarification
of the type of pathogen, using additional stains.
ANALYSIS OF THE FUNCTIONING OF PHTISIOSURGICAL SERVICE IN THE SIBERIAN AND FAR EASTERN FEDERAL DISTRICTS OF RUSSIA IN 2020–2022
Authors:   Novosibirsk Tuberculosis Research Institute, SKVORTSOV DMITRY A. , GRISCHENKO NIKOLAY G. ,   Novosibirsk Tuberculosis Research Institute, NARYSHKINA SVETLANA L. ,   Novosibirsk Tuberculosis Research Institute, MOROZOV PAVEL S. ,   Novosibirsk Tuberculosis Research Institute, STAVITSKAYA NATALYA V. ,   Novosibirsk Tuberculosis Research Institute
Published: December 2024

Introduction. In recent years, the Russian Federation has achieved some improvement in the epidemic
situation regarding tuberculosis. However, in the Siberian and Far Eastern Federal Districts of Russia, epidemiological
indicators remain above the Russian average. Surgical treatment of pulmonary tuberculosis contributes to the radical
elimination of the main source of infection in the tissue and facilitates the therapy tasks. Aim of this study is to analyze the
provision of phthisiosurgical care in the “Thoracic Surgery” profile to respiratory tuberculosis inpatients in the tuberculosis
pulmonary-surgery departments of regional and local tuberculosis dispensaries of the Siberian and Far Eastern Federal
Districts in 2020-2022. Materials and Methods. To assess the general characteristics of the phthisiosurgical service
in the above districts, we analyzed the personnel composition, bed capacity, thoracic bed operation, surgical activities,
average bed turnover, implementation of the bed-day plan, and the number of operations performed on respiratory
tuberculosis patients. The study was basedon materials provided by the statistical departments of regional and local TB
dispensaries. Results and Discussion. When comparing the indicators for the years of 2020 and 2022, a worsening
personnel shortage was found: The number of surgeons decreased from 30 to 17 in the Far Eastern Federal District
and from 35 to 29 in the Siberian Federal District. Over the past 3 years, there has been a significant decrease in the
phthisiosurgical bed capacity in the Far East. In the Siberian Federal District and, especially, in the Far Eastern Federal
District, beds in phthisiothoracic departments are often used for the purposes other than their intended one. In both the
Siberian Federal District and the Far Eastern Federal District, surgical activity rates remain quite high or is recovering
after the pandemic, except for Transbaikalia, the Republic of Buryatia, and the Amur Oblast. Conclusions. Analysis of
the performance of phthisiosurgical departments in Siberia and the Far East in 2020-2022 shows that it is necessary to
increase the number of specialized operations and improve the material and technical base of surgical departments in
the above districts, although with the increase in multidrug resistance of Mycobacterium tuberculosis to anti-tuberculosis
drugs, the role of surgical treatment methods increases. Today, only federal centers meet all the standards established
for providing surgical care to tuberculosis patients
INFLUENCE OF RESPIRATORY TUBERCULOSIS CHEMOTHERAPY ON THE ABILITY OF NEUTROPHILS TO FORM EXTRACELLULAR TRAPS
Authors:   Omsk State Medical University, ZOLOTOV ALEXANDER N. , NOVIKOV DMITRIJ G. ,   Omsk State Medical University, DYACHENKO ELENA I. ,   Omsk State Pedagogical University, MORDYK ANNA V. ,   Omsk State Medical University, ROMANOVA MARIYA А. ,   Omsk State Medical University, INDUTNY ANTON V. ,   Omsk State Medical University, KIRICHENKO NIKOLAJ А. ,   Omsk State Medical University, HOLODENKO ALEXANDER О. ,   Omsk State Medical University, PERESKOK ALEKSEJ V. ,   Omsk State Medical University
Published: December 2024

Introduction. Neutrophil extracellular traps (NETs) are essential in the pathogenesis of tuberculosis infection,
but the influence of antituberculosis chemotherapy on their formation remains unexplored. Aim. The aim of the study
was to analyze the effect of respiratory tuberculosis chemotherapy on the ability of neutrophils to form extracellular
traps. Materials and Methods. The ability of neutrophils to form extracellular traps after being exposed to a nonspecific
antigenic stimulant was studied. The study included 51 healthy children (Control Group) and 21 children with respiratory
tuberculosis (TB Group). In the “TB (point 1)” subgroup, all studies were performed at the first-time TB diagnosis, while
in the “TB (point 2)” subgroup, they were conducted 6 months after the start of tuberculosis chemotherapy. Results and
Discussion. In the children of the “TB (point 1)” subgroup, the percentage of early NETosis cells and the proportion
of cloud-shaped and filamentous neutrophil extracellular traps were significantly higher statistically as compared to
the “Control” group (p=0.0112, p=0.0041 and p=0.0093, respectively). Six months after the start of antituberculosis
chemotherapy, the ability of neutrophils to form extracellular traps changed: In the “TB (point 2)” subgroup, the proportion
of early NETosis cells decreased, only one child had cloud-shaped neutrophil extracellular traps – the other children
did not form cloud-shaped neutrophil extracellular traps, while the percentage of filamentous neutrophil extracellular
traps was not significantly different between the groups (p>0.05). Conclusions. Thus, after tuberculosis chemotherapy,
there is a preferential decrease in the percentage of cloud-shaped neutrophil extracellular traps and early NETosis cells.
BLADDER STONES IN A NINE YEARS OLD FEMALE DOG – CASE REPORT
Authors:   Department of Animal Genetics and Conservation, Institute of Animal Sciences, Warsaw University of Life Sciences, JUNDZIŁŁ-BOGUSIEWICZ Paulina , GRUSZCZYŃSKA Joanna ,   Department of Animal Genetics and Conservation, Institute of Animal Sciences, Warsaw University of Life Sciences
Published: December 2024

A nine years old female dog, crossbreed, spayed admitted to a veterinary clinic with a urinary tract problem. Symptoms have been grown slowly over six months. The dog was behaved normally at home, showing no pain. In the clinic the dog had ultrasonography of the abdominal cavity, the
bladder wall was thickened, no other shading structures were found. It was deciding to do a diagnostic
laparotomy. As a result of surgery, 4 stones were removed from the bladder. Oval stones with blunt
edges, reached about 2 cm in diameter. Often non-specific symptoms may go unnoticed for a long
time by the owner, and when the dog get to the veterinary clinic we can only chirurgic remove the
stones. Especially, if urolithiasis is sterile urolithiasis and fills the entire bladder.
POLYMORPHISM IN THE GHRL GENE AND MILK PRODUCTION TRAITS IN JERSEY CATTLE
Authors:   Department of Genetics, Faculty of Biotechnology and Animal Breeding, West Pomeranian University of Technology, Szczecin, Poland, ŚPIEWAK Magdalena , KOWALEWSKA Inga ,   Department of Genetics, Faculty of Biotechnology and Animal Breeding, West Pomeranian University of Technology, Szczecin, Poland
Published: December 2024

The aim of this study was to assess potential relationships between GHRL 4491A˃G genotypes and selected milk production traits, including milk yield, protein and fat content, and protein and
fat yield. The study involved 180 Jersey cows. Genotypes of individual animals were determined using
the ACRS and PCR-RFLP methods. The allele frequencies were as follows: A – 0.98 and G – 0.02.
The conducted research revealed statistically significant relationships (P ≤ 0.05) between GHRL genotypes and milk protein content, and tendencies were observed regarding the association of genotypes with analyzed milk production traits.
Open Reduction and Orthogonal Tension Band Plating of an Isolated Periprosthetic Tibial Tubercle Fracture
Authors: Chen Xiao T. , Jackowski Jacob R. , Wahlig Brian D. , Sems Stephen A. , Yuan Brandon J. , Hidden Krystin A.
Published: December 2024

Case:

A 67-year-old woman sustained a periprosthetic tibial tubercle avulsion fracture with extensor mechanism disruption. She underwent open reduction internal fixation (ORIF) with orthogonal mini-fragment plates applied in a tension band fashion with patellar tendon suture augmentation. Radiographs, range of motion, and patient-reported outcomes were completed over 1 year.

Conclusion:

Isolated periprosthetic tibial tubercle fractures with disruption of the extensor mechanism can be treated with ORIF using orthogonal tension band plating. At 1-year follow-up, the surgical technique described in this report yielded radiographic union, clinical restoration of preinjury motion, and excellent patient-reported outcomes.
PENGUJIAN TURBIN ANGIN DENGAN VARIASI KECEPATAN ANGIN, PUTARAN MOTOR DAN PUTARAN GENERATOR DENGAN MENGGUNAKAN TEROWONGAN ANGIN JENIS HORIZONTAL 3 BLADE
Authors: Sulaiman Sulaiman , Gunawan April
Published: December 2024

Wind tunnel (Terowongan)  angin  adalah peralatan uji berstruktur tabung dimana udara dipaksa melaju dengan sangat kencang yang mana untuk mempelajari efek aliranaerodinamis pada suatu objek benda, untuk melakukan pengujian menggunakan blade yang mana angin yang dipakai dengan kecepatan 3,4,5 dan 6 m/s. jenis blade dengan bahan kayu pinus, dengan Naca 4412, blade Naca 4412 dengan bahan resin epoxsy 70% + fiber glass 30%, blade Naca 4412 dengan bahan resin epoxsy 70% + fiber gllas 18% + serabut kelapa 12%, blade Naca 4712 dengan bahan resin epoxsy 70% + fiber glass 18% + serabut kelapa 12% dan blade Naca 5513 dengan bahan resin epoxsy 70% + fiber glass 18% + serabut kelapa 12%,  Jenis Blade resin epoksi + fiber glass + coir Naca 4412 blade yang paling tinggi putarannya dibandingkan jenis blade yang lainnya yang telah di uji,dimana putaran generator pada kecepatan angin 3 m/s putaran generaotor yang telah di hitung rata-rata nya mencapai 545.29 Rpm, kecepatan angin 4 m/s putaran generator 708.9 Rpm, pada kecepatan angin 5 m/s putaran generator 928.94 Rpm, dan pada kecepatan angin 6 m/s putaran generator 928.94 Rpm.
PENGARUH LUBANG DAN JUMLAH DISK TERHADAP PERFORMA TURBIN TESLA
Authors: Marfizal Marfizal , Wardianto Dedi , Sufiyanto Sufiyanto
Published: December 2024

Penelitian ini fokus pada Pengaruh lobang dan jumlah disk terhadap  performa turbin tesla, dimana  eksperimen ini menggunakan satu unit turbin tesla  dengan debit aliran masuk konstan 0,037 m3/s dan pembebanan konstan 50 kg pada. Kemudian dilakukan pengujian  dengan memvariasikan  jumlah lobang  pada disk ( 4, 6, 8) dan memvariasikan  jumlah disk ( 11,13, 15)  dengan diameter lobang 10 mm, diameter disk 160 mm, tebal disk 0.5 mm. setelah dilakukan pengujian dan Analisa data terlihat bahwa  variasi faktor jumlah lobang pada disk (4,6,8) dan faktor jumlah disk dapat disimpulkan bahwa  daya maksimum 310,148 Watt untuk faktor jumlah lobang pada disk sedangkan untuk faktor jumlah disk sebesar 301,154 Watt, dimana terdapat selisih sebesar 8,994 Watt. Sedangkan untuk effisiensi maksimum 73,754  untuk faktor jumlah lobang pada disk sedangkan untuk faktor jumlah disk sebesar 71,652, dimana terdapat selisih sebesar 2,102.
ANALISIS PEMODELAN PRILAKU STABILITAS LERENG DENGAN MENGGUNAKAN APLIKASI GEOSLOPE
Authors: Nofrizal Nofrizal , Nofrizal Nofrizal , Farhan Muhammad
Published: December 2024

Sitinjau Laut merupakan kawasan batuan bukit barisan yang didominasi oleh pelapukan batuan vulkanik berupa tanah liat, lempung pasir dengan batuan berukuran kerikil sampai bongkahan besar tanah liat dan lempung pasiran itu bersifat sangat plastis, jika terkena air sehingga pada tebing akan mudah memicu gerakan tanah (Ade Edwar, 2022). Pada tahun 2019 sering terjadi bencana alam longsor di ruas jalan Sitinjau Laut km 23, longsor terjadi akibat curah hujan yang tinggi dan struktur tebing yang curam dan menyebabkan jalan tidak bisa dilalui (DIBI, 2019). Jalan Sitinjau Laut merupakan sarana transportasi yang penting di Kota Padang, dampak dari longsor yang terjadi di ruas jalan Sitinjau Laut mengakibatkan terganggunya arus lalu lintas di jalan tersebut. Adapun tujuan dari penelitian ini adalah mengetahui nilai angka keamanan (Factor of Safety) dari lereng lokasi penelitian dengan menggunakan program Geo - Slope/W 2012. Dari hasil penelitian didapat kesimpulan bahwa nilai Factor of Safety (FoS) dari lereng dengan simulasi menggunakan software Geoslope/W 2012 yaitu sebesar 0,581. Dari hasil yang diperoleh dapat dikatakan bahwa lereng daerah penelitian tidak aman karena nilai Factor of Safety (FoS) kurang dari 1. Simulasi menggunakan beberapa variasi sudut 30 ̊, 45 ̊ ,60 ̊ dan 90 ̊ didapatkan nilai minimum dan maksimum Factor of Safety (FoS) kurang dari 1. Dengan demikian stabilitas lereng menggunakan beberapa variasi sudut tidak aman.