bluuebunny/crossref_metadata_2025 huggingface dataset:
ПАТОГЕНЕТИЧНІ ПАРАЛЕЛІ ЗАГАЛЬНОГО ПРОТЕОЛІЗУ ТА ОКСИДАНТНО-АНТИОКСИДАНТНОГО СТАТУСУ ПРИ ХРОНІЧНОМУ ПАНКРЕАТИТІ
Authors: Дзюбановський І. Я. , Галабіцька І. М. , Семенова І. В. , Звонар М. В. , Ониськів Л. С.
Published: October 2023

РЕЗЮМЕ. У розвитку та прогресуванні хронічного панкреатиту (ХП) доведена роль порушень антиоксидантної системи захисту (АОСЗ), активації процесів пероксидації, а також калікреїн-кінінової системи. Наявність і глибина порушень у АОСЗ та системному протеолізі взаємопов’язані та значною мірою визначають тяжкість клінічного перебігу ХП.
Мета – дослідити взаємозв’язки між показниками оксидативного стресу, АОСЗ та системного протеолізу в пацієнтів із ХП.
Матеріал і методи. Ообстежено 117 пацієнтів з ХП. Стан ПОЛ оцінювали за рівнем малонового альдегіду (МА), стан АОСЗ ферментного складу оцінювали за рівнями супероксиддисмутази (СОД) та каталази, неферментний склад АОСЗ визначали за рівнями SH-груп та церулоплазміну. Оцінку показників загального протеолізу проводили за рівнями α1-інгібітора протеїназ (α1-ІП); α2-макроглобуліну (α2-МГ); калікреїну (КК); активності кінінази ІІ прекалікреїну (ПКК); протеолітичної активності плазми (ПРА).
Результати. Виявлена наявність статистично значимих помірних кореляційних зв’язків за більшістю показників, а за рівнем α2-МГ та каталази, рівнем КК та СОД – значного кореляційного зв’язку, що доводить взаємозв’язок у дисбалансі між цими двома системами при ХП. Виявлено статистично значимий значний за силою прямий кореляційний зв’язок між даними показниками, що свідчить про статистично значимий взаємозв’язок між явищами оксидативного стресу та активацією загального протеолізу.
Висновок. Установлено статистично значимі взаємозв’язки між активацією процесів загального протеолізу, поглибленням явищ оксидативного стресу та ослабленням ферментних і неферментних АОСЗ, що свідчить про взаємообтяжливий вплив досліджуваних патогенетичних ланок ХП на прогресування захворювання.
КОРЕКЦІЯ ГЕМАТОЛОГІЧНИХ ПОКАЗНИКІВ У ПАЦІЄНТІВ З ПОРТАЛЬНОЮ ГІПЕРТЕНЗІЄЮ
Authors: Тутченко М. І. , Чуб С. Л. , Рудик Д. В. , Іванчов П. В.
Published: October 2023

РЕЗЮМЕ. Мета роботи – оцінка хірургічної тактики на покращення прогнозу виживання пацієнтів з ПГ, що ускладнена кровотечею із стравохідних вариксів, та виявлення гематологічних змін, як компенсаторного показника ПГ.
Матеріал і методи. Проаналізовано клінічний матеріал 34 пацієнтів з ПГ (середній вік – (49,09±1,65) року; 16 чоловіків, 18 жінок). Пацієнтів поділили на дві групи: перша група – 23 особи, яким усунення джерела кровотечі здійснювали шляхом лапароскопічної деваскуляризації проксимального відділу шлунка, абдомінального відділу стравоходу з наступною його транссекцією в епікардіальній ділянці; друга група – 11 пацієнтів, яким додатково виконували спленектомію.
Результати. Оцінку результатів проводили в найближчому періоді (14 діб). У першій групі виявлено збільшення рівня еритроцитів у першу добу після операції на 15,61 %, порівняно з вихідними показниками, зменшення на 11,25 % на третю добу порівняно з першою добою, і незначне підвищення на 0,72 % на одинадцяту добу, порівняно з третьою добою. В другій групі зафіксоване збільшення відповідно на 18,65 % в першу добу, зменшення на 1,31 % в третю добу і незначне зниження на 1 % до одинадцятої доби.
Динаміка лейкоцитозу мала хвилеподібний характер. У першу добу післяопераційного періоду рівень лейкоцитів зріс на 63,39 % у першій групі та на 80,56 % у другій групі, порівняно з вихідними показниками, на третю добу спостерігалось зниження на 13,34 % у першій та на 6,37 % у другій групі, порівняно з першою добою, на одинадцяту добу виявлено значне зниження лейкоцитозу на 46,67 % та 45,41 % відповідно.
Динаміка змін рівня тромбоцитів мала лінійну тенденцію до підвищення в обох групах. У першій групі підвищення не було значним: у першу добу на 3,1 %, на третю добу на 10,11 %, на одинадцяту добу на 2,49 %. У другій групі зафіксовано значне підвищення – 165,94 % в першу добу, 466,15 % на третю добу порівняно з першою добою та 177,76 % на одинадцяту добу в порівнянні з третьою добою, а в порівнянні з вихідним рівнем на 1374,95 %, тобто більш ніж в 13,5 раза.
Висновки. 1. Портальна гіпертензія призводить не тільки до суттєвих порушень у гемодинамічних показниках, у вигляді розширення вен, а й у гематологічних, які зумовлені як функціональними розладами з боку печінки, так і гіперспленізмом.

Виконання спленектомії в поєднанні із деваскуляризацією кардіального відділу шлунка та абдомінальної частини стравоходу та його апаратною транссекцією суттєво покращує гематологічні показники, і, як наслідок, зменшує кількість ускладнень та летальність.
ВПЛИВ ОБ’ЄМНОГО ПНЕВМОПРЕСИНГУ НА ПЕРИФЕРИЧНУ ГЕМОДИНАМІКУ У ОСІБ З РІЗНИМ РІВНЕМ КРОВОНАПОВНЕННЯ НИЖНІХ КІНЦІВОК
Authors: Шестеріна Д. В. , Паламарчук А. Л. , Коваленко С. О.
Published: October 2023

РЕЗЮМЕ. Одним із терапевтичних методів, що довів свою клінічну ефективність як перспективну альтернативу фармакологічним і хірургічним втручанням, є об’ємний пневмопресинг.
Мета – вивчення реакції периферичної гемодинаміки на вплив об’ємного пневмопресингу (ОП) залежно від рівня кровонаповнення нижніх кінцівок.
Матеріал і методи дослідження. У дослідженні брали участь 62 особи віком від 18 до 22 років, яким впродовж 20 хв здійснювали ОП інтенсивністю 40 мм рт. ст. приладом Recovery Pump RPX 2020 Compession (“Mego Aftek AC Ltd”, Ізраїль). Зміни параметрів периферичної гемодинаміки визначали за допомогою реовазографії, приладом ХАІ-medica standard (“ХАІ-medica”, Україна), тривалістю 15 с. Для визначення величини кровонаповнення нижніх кінцівок використали формулу, запропоновану вченими Н. Р. Палеєвим, І. М. Каєвіцером, КН=L2/Z, де КН – рівень кровонаповнення нижніх кінцівок, L – відстань між електродами струму (см), Z – рівень базового імпедансу (Ом). За значеннями цих показників визначили І групу, з відносно низьким рівнем КН, від 2,16 до 5.9, (n=30) та ІІ групу, з відносно високим КН, від 6,01 до 11,01, (n=32).
Результати. Аналіз показників периферичної гемодинаміки між групами виявив, що в період відновлення А1 збільшувався в осіб ІІ групи, А2 – зменшувався. Під час відновлення спостерігалось зменшення ФПХ в І групі, а в ІІ – збільшення ІЕСС. Вплив об’ємного пневмопресингу зумовив збільшення T в І групі, порівняно з станом спокою та періодом відновлення, на 15–20 хв. Показники Ас, Ад, Аі та РІ були вищими в обох групах. ЗПОС статистично збільшувався в І групі, а в ІІ групі – знижувався на 5–10 хв.
Висновки. Отримані результати вказують, що реакції периферичної гемодинаміки на вплив ОП різняться залежно від індивідуальних особливостей рівня кровонаповнення нижніх кінцівок.
One‐Year Outcomes and Their Relationship to Residual Mitral Regurgitation After Transcatheter Edge‐to‐Edge Repair With MitraClip Device: Insights From the OCEAN‐Mitral Registry
Authors: Kubo Shunsuke , Yamamoto Masanori , Saji Mike , Asami Masahiko , Enta Yusuke , Nakashima Masaki , Shirai Shinichi , Izumo Masaki , Mizuno Shingo , Watanabe Yusuke , Amaki Makoto , Kodama Kazuhisa , Yamaguchi Junichi , Nakajima Yoshifumi , Naganuma Toru , Bota Hiroki , Ohno Yohei , Yamawaki Masahiro , Ueno Hiroshi , Mizutani Kazuki , Adachi Yuya , Otsuka Toshiaki , Hayashida Kentaro , Hayashida Kentaro , Adachi Yuya , Yamamoto Masanori , Yamamoto Masanori , Shirai Shinichi , Watanabe Yusuke , Naganuma Toru , Yamawaki Masahiro , Enta Yusuke , Nakashima Masaki , Mizuno Shingo , Ueno Hiroshi , Ohno Yohei , Nakajima Yoshifumi , Izumo Masaki , Bota Hiroki , Kodama Kazuhisa , Yamaguchi Junichi , Kubo Shunsuke , Amaki Makoto , Asami Masahiko , Saji Mike , Mizutani Kazuki
Published: October 2023

Background

Limited data are available about clinical outcomes and residual mitral regurgitation (MR) after transcatheter edge‐to‐edge repair in the large Asian‐Pacific cohort.

Methods and Results

From the Optimized Catheter Valvular Intervention (OCEAN‐Mitral) registry, a total of 2150 patients (primary cause of 34.6%) undergoing transcatheter edge‐to‐edge repair were analyzed and classified into 3 groups according to the residual MR severity at discharge: MR 0+/1+, 2+, and 3+/4+. The mortality and heart failure hospitalization rates at 1 year were 12.3% and 15.0%, respectively. Both MR and symptomatic improvement were sustained at 1 year with MR ≤2+ in 94.1% of patients and New York Heart Association functional class I/II in 95.0% of patients. Compared with residual MR 0+/1+ (20.4%) at discharge, both residual MR 2+ (30.2%;
P
 < 0.001) and 3+/4+ (32.4%;
P
 = 0.007) were associated with the higher incidence of death or heart failure hospitalization (adjusted hazard ratio [HR], 1.59;
P
 < 0.001, and adjusted HR, 1.73;
P
 = 0.008). New York Heart Association class III/IV at 1 year was more common in the MR 3+/4+ group (20.0%) than in the MR 0+/1+ (4.6%;
P
 < 0.001) and MR 2+ (6.4%;
P
 < 0.001) groups, and the proportion of New York Heart Association class I is significantly higher in the MR 1+ group (57.8%) than in the MR 2+ group (48.3%;
P
 = 0.02).

Conclusions

The OCEAN‐Mitral registry demonstrated favorable clinical outcomes and sustained MR reduction at 1 year in patients undergoing transcatheter edge‐to‐edge repair. Both residual MR 2+ and 3+/4+ after transcatheter edge‐to‐edge repair at discharge were associated with worse clinical outcomes compared with residual MR 0+/1+.

Registration Information

https://upload.umin.ac.jp
. Identifier: UMIN000023653.
Reception and Makings of African Vocal Ensemble Sounds beyond Binaries
Authors: Moshugi Kgomotso
Published: October 2023

Since 1877, the Seventh-day Adventist (SDA) Church from North America has established its presence in Southern Africa. As with missionization in other denominations, this introduced a variety of primarily Euro-American musical influences into African religious practices. Over the years, Adventist musicians have constantly negotiated a complex relationship to their African contexts, often yielding musical outcomes that cannot be reduced simply to an indigenous vs exogenous or ‘African’ vs ‘Western’ binary evaluation. This intersectional phenomenon is not thoroughly explored in the current scholarship on SDA music. This paper provides background and details on collaborations and exchanges in various repertoires since the 1980s. I argue that these embody intersectional ideas that emerge beyond geographical, cultural, and chronological boundaries. The study is developed from analyzing unstructured interviews and audio recordings to illustrate perpetually blurred boundaries in musical practices that have conventionally distinguished “African” vocal sound.
Evaluation of morpho-physiological and biochemical indicators of salinity stress in Argemone mexicana L., medicinal plant from Papaveraceae
Authors: Unnikrishnan Sneha , Resmi Mohankumar Saraladevi , Mohan Gopika , Vivek Padmanabhan Jayanthikumari
Published: October 2023

Plant growth is significantly impacted by abiotic stress factors including soil salinity and plants do have different mechanism to nullify the effect of these stresses. The current study is to understand the various physio-biochemical characteristics of Mexican prickly poppy (Argemone mexicana L.), a medicinally valued species belongs to poppy family under different saline conditions (0 mM, 100 mM, 200 mM and 300 mM) to investigate the mechanisms underlying salinity tolerance. The results showed that salinity caused a negative impact on number of leaves, stomatal index and chlorophyll content in plants. Decreased chlorophyll content suggests a decline in photosynthetic rate. The concentrations of stress specific amino acid proline, soluble sugar sucrose, and secondary metabolite phenol were increased in plants treated with increasing concentrations of NaCl solution. Sucrose helps to protect the isolated chloroplast from damage caused by salinity stress. The degree of bleaching seen in the leaf disc assay was an indication of the damage caused by stress. These findings indicated that higher proline, sugar, and phenol content could be the key factors, which offer advantage to Argemone under saline conditions.
Microlicia indurata (Melastomataceae: Lavoisiereae), a new narrow endemic from Serra dos Pireneus, Goiás, Brazil
Authors: ALMEDA FRANK , PACIFICO RICARDO , MARTINS ANGELA B. , MEDEIROS JOÃO DE DEUS
Published: October 2023

Microlicia indurata is described as a new species from cerrado rupestre in the Serra dos Pireneus of Goiás, Brazil. Illustrations, photos taken in the field, a distribution map, a recommended conservation assessment, and a discussion of putative related species based on morphological similarities are provided. Microlicia indurata is readily recognized by its openly branched shrubby habit, sessile elliptic-lanceolate to elliptic-ovate 5–7-nerved leaf blades that are moderately to copiously covered with short (mostly 0.5–0.7 mm) gland-tipped trichomes on both surfaces, 6-merous, solitary, sessile flowers, caducous calyx lobes that greatly exceed the hypanthia at anthesis, white petals, red antesepalous (large) anthers, 6-locular ovaries that are ca. ⅓ inferior, and mature capsules that are hard and woody with a somewhat protruding tapered acute apex. It is compared with M. pohliana, its presumed closest relative, and the superficially similar M. mucorifera and M. nervulosa.
Macropsychanthus nitidus: a new rank and combination for dioclea rostrata var. nitida (leguminosae, papilionoideae)
Authors: FONSECA-CORTÉS ANDRÉS , SNAK CRISTIANE , QUEIROZ LUCIANO PAGANUCCI DE
Published: October 2023

As a part of the studies in Neotropical Macropsychanthus, we propose a new rank and combination for Dioclea rostrata var. nitida: Macropsychantbus nitidus. This species is unique in the genus by the combination of leaf rachis to 2 cm long, leaflet undersurface sericeous argenteus and keel apex straight. Although this species was included as a variety of Dioclea rostrata or as a synonym of Macropsychanthus bicolor, we discuss why it should be recognized as a different species. A detailed taxonomic description, distribution map, illustration, and a discussion with similar taxa are provided.
The complexity of multidisciplinary respiratory care in amyotrophic lateral sclerosis
Authors: Berlowitz David J. , Mathers Susan , Hutchinson Karen , Hogden Anne , Carey Kate A. , Graco Marnie , Whelan Brooke-Mai , Charania Salma , Steyn Frederik , Allcroft Peter , Crook Ashley , Sheers Nicole L.
Published: October 2023

Motor neurone disease/amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no known cure, where death is usually secondary to progressive respiratory failure. Assisting people with ALS through their disease journey is complex and supported by clinics that provide comprehensive multidisciplinary care (MDC).

This review aims to apply both a respiratory and a complexity lens to the key roles and areas of practice within the MDC model in ALS. Models of noninvasive ventilation care, and considerations in the provision of palliative therapy, respiratory support, and speech and language therapy are discussed. The impact on people living with ALS of both inequitable funding models and the complexity of clinical care decisions are illustrated using case vignettes. Considerations of the impact of emerging antisense and gene modifying therapies on MDC challenges are also highlighted.

The review seeks to illustrate how MDC members contribute to collective decision-making in ALS, how the sum of the parts is greater than any individual care component or health professional, and that the MDC
per se
adds value to the person living with ALS. Through this approach we hope to support clinicians to navigate the space between what are minimum, guideline-driven, standards of care and what excellent, person-centred ALS care that fully embraces complexity could be.

Educational aims

To highlight the complexities surrounding respiratory care in ALS.

To alert clinicians to the risk that complexity of ALS care may modify the effectiveness of any specific, evidence-based therapy for ALS.

To describe the importance of person-centred care and shared decision-making in optimising care in ALS.
The effect of cognitive behavioral therapy on stress and anxiety of mothers of girls with precocious puberty symptoms: a randomized controlled trial
Authors: Rahimi Faranak , Mirghafourvand Mojgan , Farvareshi Mahmoud , Yavarikia Parisa
Published: October 2023

Introduction

: Precocious puberty in girls has been associated with an increased risk of stress and anxiety in their mothers. This study aimed to investigate the effect of cognitive behavioral therapy (CBT) on perceived stress and anxiety of mothers of girls with precocious puberty symptoms.

Methods

This randomized controlled trial was conducted on 70 mothers of girls with precocious puberty symptoms in Tabriz-Iran, 2021. The participants were randomly assigned to CBT and control groups through blocked randomization. Group counseling was provided to the intervention group in eight sessions of 45–60 min weekly with 5 to 7 women. A booklet containing explanations about puberty was provided for the both groups. Data were collected using the questionnaires of socio-demographic characteristics, Spielberger State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS) and quality of life (SF-36). Independent t-test, ANCOVA, chi-square, and fisher’s exact tests were used to compare the outcomes between the groups.

Findings

: After the intervention, based on ANCOVA test with adjusting the baseline values, mean scores of stress (mean difference (MD): -10.75; 95% confidence interval (95% CI): -11.77 to -9.72; P < 0.001), state anxiety (MD: -14.36; 95% CI: -15.7 to -12.7; P < 0.001) and trait anxiety (MD: -12.8; 95% CI: -14.4 to -11.1; P < 0.001) were significantly lower in CBT group compared to the control group. Also mean score of quality of life (MD: 9.82; 95% CI: -6.74 to -12.90; P < 0.001) was significantly higher in CBT group compared to the control group.

Conclusion

Based on the results, group CBT is effective in reducing stress and anxiety and improving the quality of life of mothers of girls with precocious puberty symptoms. However, more studies are required to make a definite conclusion in this field.

Trial registration

Iranian Registry of Clinical Trials (IRCT): IRCT20110826007418N6. Date of registration: 11/10/2021. URL: https://en.irct.ir/trial/57346; Date of first registration: 11/10/2021.
Depression among patients with chronic kidney disease, associated factors, and predictors: a cross-sectional study
Authors: Bahall Mandreker , Legall George , Lalla Carlyle
Published: October 2023

Background

Depression with diverse etiologies is exacerbated by chronic diseases, such as chronic kidney disease (CKD), coronary artery disease (CAD), cancer, diabetes mellitus, and hypertension. This study aimed to analyse depression, its associations, and predictors among patients attending the kidney clinic of a teaching hospital.

Methods

Data were collected from 01 August 2017 to 30 September 2017 via face-to-face interviews and examination of the medical records of a convenience sample of 314 patients. The patients were categorised broadly as stages I and II with an estimated glomerular filtration rate (eGFR) > 60 mls/min/1.73 m2, and with stages III, IV, and V or GFR ≤ 60 mls/ min/1.73 m2 (or CKD). The Patient Health Questionnaire (PHQ)-9 was the data collection instrument for depression-related data.

Results

Participants were predominantly male (n = 179; 57.0%), aged over 60 years (n = 211; 67.2%), Indo-Trinbagonian (n = 237; 75.5%), and with stages III, IV, and V CKD. The two leading comorbid conditions were hypertension (83.4%) and diabetes mellitus (56.1%). Of the 261 (83.1%) patients with recorded eGFR, 113 (43.3%) had Stage III CKD. The mean depression (PHQ-9) score was 13.0/27 ($$\pm$$9.15), with 306 (97.5%) patients diagnosed as having depression with the following severities: mild (n = 116; 37.9%), moderate (n = 138, 45.1%), moderately severe (n = 38; 12.4%), and severe (n = 14; 4.6%). Depression was independent of sex. Nine sociodemographic variables were associated with depression; however, ‘level of education’, was the only predictor of depression with greater severity associated with lower levels of education. eGFR was negatively correlated with the PHQ-9 scores (Pearson’s correlation, r = -0.144, p = 0.022). At least 78.3% of the patients who self-reported no depression had clinical depression (moderate, moderately severe, or severe) PHQ-9 scores ≥ 10.

Conclusion

Depression was a significant comorbidity among patients with CKD, with the majority displaying clinical depression. “Level of education” was the only predictor of depression. Self-reported depression is an unreliable method for evaluating clinical depression.
Development of a knowledge-based healthcare-associated infections surveillance system in China
Authors: Cao Yu , Niu Yaojun , Tian Xuetao , Peng DeZhong , Lu Li , Zhang Haojun
Published: October 2023

Background

In the modern era of antibiotics, healthcare-associated infections (HAIs) have emerged as a prominent and concerning health threat worldwide. Implementing an electronic surveillance system for healthcare-associated infections offers the potential to not only alleviate the manual workload of clinical physicians in surveillance and reporting but also enhance patient safety and the overall quality of medical care. Despite the widespread adoption of healthcare-associated infections surveillance systems in numerous hospitals across China, several challenges persist. These encompass incomplete coverage of all infection types in the surveillance, lack of clarity in the alerting results provided by the system, and discrepancies in sensitivity and specificity that fall short of practical expectations.

Methods

We design and develop a knowledge-based healthcare-associated infections surveillance system (KBHAIS) with the primary goal of supporting clinicians in their surveillance of HAIs. The system operates by automatically extracting infection factors from both structured and unstructured electronic health data. Each patient visit is represented as a tuple list, which is then processed by the rule engine within KBHAIS. As a result, the system generates comprehensive warning results, encompassing infection site, infection diagnoses, infection time, and infection probability. These knowledge rules utilized by the rule engine are derived from infection-related clinical guidelines and the collective expertise of domain experts.

Results

We develop and evaluate our KBHAIS on a dataset of 106,769 samples collected from 84,839 patients at Gansu Provincial Hospital in China. The experimental results reveal that the system achieves a sensitivity rate surpassing 0.83, offering compelling evidence of its effectiveness and reliability.

Conclusions

Our healthcare-associated infections surveillance system demonstrates its effectiveness in promptly alerting patients to healthcare-associated infections. Consequently, our system holds the potential to considerably diminish the occurrence of delayed and missed reporting of such infections, thereby bolstering patient safety and elevating the overall quality of healthcare delivery.
Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study
Authors: Gao Hui , Zheng Shuhao , Yuan Xin , Xie Jiarong , Xu Lei
Published: October 2023

Background

The risk of extracolonic cancer is increased in inflammatory bowel disease (IBD) patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationship between IBD and extracolonic cancers.

Methods

Independent genetic variants strongly associated with IBD were extracted as instrumental variables from genome-wide association study (GWAS) conducted by the International IBD Genetics Consortium including 12,882 IBD patients, 5956 Crohn’s disease (CD) patients, and 6968 ulcerative colitis (UC) patients. Three sources of cancer GWAS were selected as outcome data. Two-sample Mendelian randomization (MR) analysis was conducted to assess the causal effects of IBD on 32 extracolonic cancers. The meta-analysis was applied to assess the combined causal effect with multiple MR results.

Results

IBD, CD, and UC have potential causal associations with oral cavity cancer (IBD: OR = 1.180, 95% CI: 1.059 to 1.316, P = 0.003; CD: OR = 1.112, 95% CI: 1.008 to 1.227, P = 0.034; UC: OR = 1.158, 95% CI: 1.041 to 1.288, P = 0.007). Meta-analysis showed a significant positive causal relationship between IBD and breast cancer (OR = 1.059; 95% CI: 1.033 to 1.086; P < 0.0001) as well as a potential causal relationship between CD and breast cancer (OR = 1.029; 95% CI: 1.002 to 1.055; P = 0.032) based on combining multiple MR results.

Conclusions

This comprehensive MR analysis suggested that genetically predicted IBD, as well as its subtypes, may be a risk factor in the development of oral cavity and breast cancer.
The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis
Authors: Wang Yue-peng , Di Wen-jia , Yang Su , Qin Shi-lei , Xu Yun-feng , Han Peng-fei , Hou Ke-dong
Published: October 2023

Background

Osteoarthritis (OA) is caused by a complex set of pathophysiological factors. The genetic factors involved in the occurrence and progress of the disease have been widely discussed by scholars. It was found that growth differentiation factor 5 (GDF5) gene polymorphisms may be linked to OA susceptibility, which has been controversial and needs to be further confirmed by an updated meta-analysis.

Objectives

We examined the association between GDF5 rs143383 single nucleotide polymorphism (SNP) and OA susceptibility.

Methods

All relevant articles that met the criteria are retrieved and included, and the search deadline is June 2022. The allele frequencies and different genotype frequencies of GDF5 rs143383 loci in each study were extracted and statistically analyzed by R4.1.3 software, and the different genetic models were analyzed based on their odds ratio (OR) and 95% confidence interval (CI).

Results

The meta-analysis explained that GDF5 rs143383 SNP was crucial correlated with OA in all patients with OA of knee, hip and hand. The codominant gene model in the whole crowd (OR = 1.17, 95% CI 1.07–1.27, P < 0.01) enlightened that OA was vitally associated with GDF5 gene polymorphism. At the same time, we did a subgroup analysis based on ethnicity. The codominant gene model (OR = 1.31, 95% CI 1.12–1.53, P < 0.01) in Asian population, the codominant homozygote model (OR = 1.28, 95% CI 1.14–1.43), codominant heterozygote gene model (OR = 1.12, 95% CI 1.01–1.23, P = 0.02), and dominant gene model (OR = 1.19, 95% CI 1.09–1.31, P < 0.01) in Caucasian are analyzed by subgroup analysis. It means that there is a momentous relationship between the GDF5rs143383 gene polymorphism and OA, especially among Caucasians. In addition, we also discussed different types of OA separately and discover that the GDF5rs143383 gene polymorphism was relevant for knee osteoarthritis (KOA) and hand osteoarthritis, and it was more significant in the Caucasian population. But due to the high heterogeneity in hip osteoarthritis, it could not be accurately concluded. Furthermore, we also analyzed the osteoarthritis of different genders and found that the GDF5 rs143383 SNP was associated with both men and women and was still significant in the Caucasian population.

Conclusion

We found a close association between osteoarthritis and GDF5rs143383SNP in this study. From the analysis of each group, we got the same conclusion in KOA and hand OA, but which need further verification in hip OA. Considering gender, we found a close relationship between GDF5 rs143383 SNP and OA of the knee, hip and hand, both for men and women. This conclusion is more obvious in Caucasian people.
Excision of left atrial myxoma under perfused ventricular fibrillation with hypothermia after coronary artery bypass grafting
Authors: Pan Shaobo , Wang Yalin , Gu Yanjia , Li Weidong , Xu Hongfei
Published: October 2023

Background

Redo heart surgery has become increasingly common but involves additional high surgical risk, especially redo surgery after coronary artery bypass grafting (CABG).

Case presentation

In this study, we report the case of a 57-year-old Chinese male with left atrium myxoma who had previously undergone CABG. Common surgical methods usually include aortic cross-clamping, administering cold cardioplegia perfusion to protect the myocardium, opening the heart, and then removing the tumor. However, for patients with previous CABG, redo thoracotomy and ascending aortic cross-clamping present a greater risk of damage to the grafted vessels. In this study, we chose a right lateral mini-thoracotomy incision and hypothermia-induced ventricular fibrillation to minimize damage and avoid any adverse effects on the bridge vasculature. The patient recovered uneventfully and was discharged seven days after surgery.

Conclusions

For patients with previous CABG, minimally invasive right thoracotomy under perfused ventricular fibrillation with hypothermia is safe and reliable and can prevent potential damage to the ascending aorta and graft.
Assessment of degradability and endothelialization of modified poly L-lactic acid (PLLA) atrial septal defect (ASD) occluders over time in vivo
Authors: Chen Jun , Xie Yumei , Li Yifan , Chen Xianmiao , Fu Mingjuan , Liu Yanfen , Zhang Zhiwei
Published: October 2023

Objective

To evaluate the fiber-degradation and endothelialization of a modified poly L-lactic acid (PLLA) atrial septal defect (ASD) occluder for a long time in vivo.

Methods

A total of 57 New Zealand rabbits were selected to establish the vasculature implantation model, which would be used to characterize the mechanical properties and pathological reaction of PLLA filaments (a raw polymer of ASD occluder). In total, 27 Experimental piglets were used to create the ASD model for the catheter implantation of PLLA ASD occluders. Then, X-ray imaging, transthoracic echocardiography, histopathology, and scanning electron microscope (SEM) were performed in the experimental animals at 3, 6, 12, and 24 months after implantation.

Results

In the rabbit models, the fibrocystic grade was 0 and the inflammatory response was grade 2 at 6 months after vasculature implantation of the PLLA filaments. The mass loss of PLLA filaments increased appreciably with the increasing duration of implantation, but their mechanical strength was decreased without broken. In the porcine models, the cardiac gross anatomy showed that all PLLA ASD occluders were stable in the interatrial septum without any vegetation or thrombus formation. At 24 months, the occluders had been embedded into endogenous host tissue nearly. Pathological observations suggested that the occluders degraded gradually without complications at different periods. SEM showed that the occluders were endothelialized completely and essentially became an integral part of the body over time.

Conclusion

In the animal model, the modified PLLA ASD occluders exhibited good degradability and endothelialization in this long-term follow-up study.
Effects of COVID-19 on diabetes care among dutch diabetes outpatients
Authors: Bak Jessica C.G. , Serné Erik H. , Groenwold Rolf H.H. , de Valk Harold W. , Kramer Mark H.H. , Nieuwdorp Max , Verheugt Carianne L.
Published: October 2023

Aims

The COVID-19 pandemic impacted diabetes care by reducing diabetes outpatient visits and diabetes-related screening due to allocation of healthcare resources. Yet the impact of COVID-19 on diabetes outpatients has not been extensively evaluated. This study aimed to assess the effect of the COVID-19 pandemic on diagnostics and intermediate outcomes of outpatient diabetes care pre- and during COVID.

Methods

This observational cohort study included 8,442 diabetes patients in the Dutch Pediatric and Adult Registry of Diabetes (DPARD) visiting diabetes outpatient clinics in 2019 and 2021. A mixed-effects regression analysis was used to examine differences in target achievement of HbA1c, BMI, blood pressure, LDL-cholesterol, eGFR, and the difference in mean HbA1c between 2019 and 2020 among n = 1,426 outpatients who visited in both years. Analyses were adjusted for age, sex, and BMI.

Results

A 22.7% (21.6–23.8%, p < 0.001) decline in outpatient volume was observed during the pandemic (2020). BMI, lipid spectrum, kidney function, and HbA1c were assessed less frequently in 2020 than in 2019. In 2020, compared to 2019, the median HbA1c level increased by 2.2% (1.0 mmol/mol, p = 0.035) and the percentages of patients with known HbA1C meeting targets below 10, 8, 7% (86, 64, and 53 mmol/mol) decreased by 0.5%, 1.7% and 1.4%, respectively. Target blood pressure ≤ 130/80 mmHg was achieved more often in 2020 (15.0% versus 18.3%, p = 0.018), while HbA1c ≤ 86 mmol/mol was achieved less (89.3% versus 87.1%, p = 0.001), among diabetes outpatients seen in both 2019 and 2020. In patients visiting both years, HbA1c was 2.3% (1.9 mmol/l, 95% CI 1.2–2.5, p < 0.001) lower during the pandemic than in the prepandemic (2019).

Conclusions

The COVID pandemic was associated with a marked reduction in patient volume in diabetes outpatient care among five hospitals. Among patients who received outpatient care both before and during the pandemic period, HbA1c control and blood pressure control enhanced during the pandemic. Re-evaluation of current diabetes outpatient care organization is warranted to ensure optimal diabetes care in future times.
Change in quality of life and return to work and sports after isolated closing-wedge distal femoral osteotomy
Authors: Fang Qian , Wang Dong , Liu Wenzheng , Lin Wei , Wang Guanglin
Published: October 2023

Purpose

To analyze return to work and sports, and health-related quality of life (HRQoL) after closing-wedge distal femoral osteotomy (CWDFO) for valgus deformity and lateral compartmental osteoarthritis.

Methods

Thirty-three patients underwent isolated CWDFO in our center between January 2018 and June 2020 were enrolled, of whom 32 and 23 patients were included in the return-to-work and return-to-sports analyses, respectively. Short Form-36 (SF-36), Tegner score, Knee injury and Osteoarthritis Outcome Score (KOOS) and visual analog scale (VAS) pain score were compared preoperatively and postoperatively. And postoperative complications were recorded.

Results

Overall, 33 patients were contacted at a mean follow-up of 37.94 ± 6.68 months, with a median age of 35 years (range: 26–63 years) at the surgery time. The physical component summary of SF-36 (p < 0.001) increased significantly at 1 year postoperatively. All patients returned to work, including 96.86% who returned to the same level of work in 1.89 ± 0.98 months, and to sports, including 78.26% who returned to the same sport level in 6.50 ± 2.05 months. Rates of returning to work (p = 0.215) and sports (p = 0.165) did not differ with work/sports intensity. Tegner scores (p = 0.025) and VAS pain scores (p < 0.001) decreased, and KOOS (p < 0.001) increased at 1 year postoperatively. Revision/conversion surgery was not required. In all, 30.43% patients reported a subjective decrease in sports ability; 82.61% patients considered their sports ability acceptable.

Conclusion

Patients returned to work/sports after isolated CWDFO, and had increased HRQoL. Patients playing high-impact sports had lower rates of returning to the same sport level, and may require preoperative counseling.

Level of evidence

IV, Case series.
MRI feature-based radiomics models to predict treatment outcome after stereotactic body radiotherapy for spinal metastases
Authors: Chen Yongye , Qin Siyuan , Zhao Weili , Wang Qizheng , Liu Ke , Xin Peijin , Yuan Huishu , Zhuang Hongqing , Lang Ning
Published: October 2023

Objective

This study aimed to extract radiomics features from MRI using machine learning (ML) algorithms and integrate them with clinical features to build response prediction models for patients with spinal metastases undergoing stereotactic body radiotherapy (SBRT).

Methods

Patients with spinal metastases who were treated using SBRT at our hospital between July 2018 and April 2023 were recruited. We assessed their response to treatment using the revised Response Evaluation Criteria in Solid Tumors (version 1.1). The lesions were categorized into progressive disease (PD) and non-PD groups. Radiomics features were extracted from T1-weighted image (T1WI), T2-weighted image (T2WI), and fat-suppression T2WI sequences. Feature selection involved intraclass correlation coefficients, minimal-redundancy-maximal-relevance, and least absolute shrinkage and selection operator methods. Thirteen ML algorithms were employed to construct the radiomics prediction models. Clinical, conventional imaging, and radiomics features were integrated to develop combined models. Model performance was evaluated using receiver operating characteristic (ROC) curve analysis, and the clinical value was assessed using decision curve analysis.

Results

We included 194 patients with 142 (73.2%) lesions in the non-PD group and 52 (26.8%) in the PD group. Each region of interest generated 2264 features. The clinical model exhibited a moderate predictive value (area under the ROC curve, AUC = 0.733), while the radiomics models demonstrated better performance (AUC = 0.745–0.825). The combined model achieved the best performance (AUC = 0.828).

Conclusion

The MRI-based radiomics models exhibited valuable predictive capability for treatment outcomes in patients with spinal metastases undergoing SBRT.

Critical relevance statement

Radiomics prediction models have the potential to contribute to clinical decision-making and improve the prognosis of patients with spinal metastases undergoing SBRT.

Key points

• Stereotactic body radiotherapy effectively delivers high doses of radiation to treat spinal metastases.

• Accurate prediction of treatment outcomes has crucial clinical significance.

• MRI-based radiomics models demonstrated good performance to predict treatment outcomes.

Graphical Abstract
Vascular organoids: unveiling advantages, applications, challenges, and disease modelling strategies
Authors: Naderi-Meshkin Hojjat , Cornelius Victoria A. , Eleftheriadou Magdalini , Potel Koray Niels , Setyaningsih Wiwit Ananda Wahyu , Margariti Andriana
Published: October 2023

Understanding mechanisms and manifestations of cardiovascular risk factors, including diabetes, on vascular cells such as endothelial cells, pericytes, and vascular smooth muscle cells, remains elusive partly due to the lack of appropriate disease models. Therefore, here we explore different aspects for the development of advanced 3D in vitro disease models that recapitulate human blood vessel complications using patient-derived induced pluripotent stem cells, which retain the epigenetic, transcriptomic, and metabolic memory of their patient-of-origin. In this review, we highlight the superiority of 3D blood vessel organoids over conventional 2D cell culture systems for vascular research. We outline the key benefits of vascular organoids in both health and disease contexts and discuss the current challenges associated with organoid technology, providing potential solutions. Furthermore, we discuss the diverse applications of vascular organoids and emphasize the importance of incorporating all relevant cellular components in a 3D model to accurately recapitulate vascular pathophysiology. As a specific example, we present a comprehensive overview of diabetic vasculopathy, demonstrating how the interplay of different vascular cell types is critical for the successful modelling of complex disease processes in vitro. Finally, we propose a strategy for creating an organ-specific diabetic vasculopathy model, serving as a valuable template for modelling other types of vascular complications in cardiovascular diseases by incorporating disease-specific stressors and organotypic modifications.

Graphical abstract
A Simple 3D Printed Model for Intracranial Vascular Anastomosis Practice and the Rochester Bypass Training Score
Authors: Rahmani Redi , Santangelo Gabrielle , Jalal Muhammad I. , Catanzaro Michael , Samodal Joshua , Bender Matthew T. , Stone Jonathan J.
Published: October 2023

BACKGROUND AND OBJECTIVES:

Surgical simulation models in cranial neurosurgery are needed to allow affordable, accessible, and validated practice in resident education. Current bypass anastomosis practice models revolve around basic tube tying or complex animal and 3-dimensional models. This study sought to design and validate a 3-dimensional printed model for intracranial anastomosis training.

METHODS:

A computer-aided design (CAD) generic skull was uploaded into Meshmixer (v.3.5), and a 55-mm opening was created on the right side, mimicking a standard orbitozygomatic craniotomy. The model was rotated 15° upward and 35° left, before a 10-mm square frame was added 80-mm deep to the right orbit. The CAD model was uploaded to GrabCAD and printed using a J750 PolyJet 3D printer before being paired with a vascular anastomosis kit. The model was validated with standardized assessments of residents and attendings by simulating an “M2 to P2” bypass. The Rochester Bypass Training Score (RBTS) was created to assess bypass patency, back wall suturing, and suture quality. Postsimulation survey data regarding the realism and usefulness of the simulation were collected.

RESULTS:

Five junior residents (Postgraduate Year 1-4), 3 senior residents (Postgraduate Year 5-7), and 2 attendings were participated. The mean operative time in minutes was as follows: junior residents 78, senior residents 33, and attendings 50. The RBTS means were as follows: junior residents 2.4, senior residents 4.0, and attendings 5.0. Participants agreed that the model was realistic, useful for improving operative technique, and would increase comfort in bypass procedures. There are a few different printing options, varying in model infill and printing material used. For this experiment, a mix of Vero plastics were used totaling $309.09 per model; however, using the more common printing material polylactic acid brings the cost to $17.27 for a comparable model.

CONCLUSION:

This study presents an affordable, realistic, and educational intracranial vascular anastomosis simulator and introduces the RBTS for assessment.
Lenguaje y sociedad. Acercamientos, teorías, problemas y perspectivas.
Authors: Camus Zoé
Published: October 2023

En esta obra se reúne una serie de novedosas propuestas teóricas, metodológicas y descriptivas que aborda la relación entre lenguaje y sociedad. Los siete estudios que conforman el volumen pertenecen a especialistas del ámbito académico de Brasil, España y Francia; sus contribuciones se estructuran en torno a tres ejes temáticos: la conflictividad política, la enseñanza en contexto intercultural y la variación sociolingüística. La riqueza aportada por las distintas perspectivas origina una visión panorámica sobre las investigaciones que se están desarrollando en la actualidad en este ámbito, en la que es imposible trazar una línea fronteriza entre lo estrictamente lingüístico y lo social.
A ocupação da Idade do Ferro de Lisboa (Portugal): novos dados sobre as intervenções realizadas no Largo de Santa Cruz do Castelo.
Authors: Sandra Guerra Elisa
Published: October 2023

Neste trabalho apresentam-se os dados estratigráficos e materiais resultantes de uma escavação de arqueologia urbana efectuada no topo da Colina do Castelo de São Jorge (Lisboa, Portugal), correspondente ao núcleo primário da ocupação da Idade do Ferro. Foram documentadas cinco fases de ocupação, integradas cronologicamente entre o século VII e IV a.C. O espólio recuperado nos níveis conservados, que engloba ânforas, cerâmicas de engobe vermelho, cerâmicas cinzentas, comuns e pintadas, e também produções manuais e alguns escassos artefactos metálicos, é analisado na sua globalidade. Foram totalizados mais de 780 indivíduos, correspondendo a um dos maiores conjuntos artefactuais recolhidos, até ao momento, na cidade. Os dados obtidos permitem tecer algumas considerações sobre a evolução deste núcleo ao longo do 1° milénio a.C., colmatando algumas lacunas do seu faseamento e consolidando as seriações artefactuais e cronológicas para o Baixo Tejo.
Exploración no invasiva de un poblado fortificado de la etapa tardorrepublicana en el valle del Tajo. El Cerro de la Breña (Talaván, Cáceres).
Authors: Mayoral Herrera Victorino , Pro Muñoz Carmen , García Sánchez Jesús , Tena Rey María Teresa de , Terrón López José María , Quirós Rosado Elia , Gil Llorente Andrea
Published: October 2023

En este trabajo se muestran los primeros resultados de una exploración del asentamiento fortificado del Cerro de la Breña (Talaván, Cáceres), principalmente mediante la combinación de una batería de sistemas de registro no invasivos (prospección geomagnética, georradar, tomografía eléctrica y LiDAR). Los resultados acreditan la existencia de un complejo sistema defensivo, que encerraría una trama urbana densa y regular. Estos datos son valorados a la luz del conocimiento previo que existía sobre el sitio, para así poder avanzar una lectura en términos históricos del sentido de este asentamiento. Este marco se define como un proceso de transformación de la estructura territorial del valle medio del Tajo (actual Alta Extremadura) a caballo entre el final de la Edad del Hierro y los primeros momentos de la dominación romana. Se valora en este sentido el contexto geográfico y la evidencia disponible sobre otros sitios arqueológicos del entorno. La propuesta de interpretación se orienta a considerar al Cerro de la Breña como un asentamiento directamente vinculado con la implantación romana entre finales del siglo II e inicios del siglo I a.C
Banquetes con ostras y emulación de hábitos itálicos en Hispania: el depósito arqueomalacológico de Los Bañales de Uncastillo (Zaragoza) en territorio vascón.
Authors: Bernal-Casasola Darío , Andreu Pintado Javier , Cantillo Duarte Juan Jesús
Published: October 2023

Las ostras constituyen un aspecto muy poco estudiado de la economía hispanorromana. Se presenta el estudio arqueomalacológico de un depósito inédito de ostras planas (Ostrea edulis) localizado en Los Bañales (Uncastillo, Zaragoza), fechado en los últimos momentos de vida de la ciudad romana (época tardoantoniniana-primo severiana). El depósito se ha interpretado como los restos de un banquete privado asociado a una domus por su abundancia (71 NMI) y por su relación con restos de vajilla cerámica, formando parte de un vertedero sobre el acerado (crepido) de uno de los cardines, ya sin mantenimiento en estas fechas. Se reflexiona sobre la importancia de estos hallazgos como símbolo de distinción social y de aemulatio itálica, se discute sobre su procedencia mediterránea o cantábrica, y se realiza una comparativa biométrica con otros hallazgos similares hispanorromanos, especialmente del área del Fretum Gaditanum, de donde procede el único paralelo de convivium similar conocido hasta la fecha (Baelo Claudia). Este trabajo reivindica, asimismo, la necesidad e importancia de los estudios arqueomalacológicos en Hispania para el desarrollo de múltiples aspectos socio-económicos de las sociedades antiguas, actualmente infravalorados