bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome
Authors: Zhen Gao , Upur Halmurat , Jing Wang , Jing Jing , Zheng Li , Dan Xu , Fengsen Li
Published: May 2017

Objective. To investigate the effect of abnormal savda munziq (ASM) on the pulmonary function and expression of lung‐specific aquaporins in the rat model of chronic obstructive pulmonary disease with abnormal savda syndrome (ASSCOPD). Methods. Eighty male rats were randomized into ASSCOPD, COPD, and control groups. ASSCOPD was further categorized into ASM and non‐ASM groups. COPD model was established by combining fumigation with airway instillation of elastase; ASSCOPD model was developed based on COPD by induction with dry cold diet, cold dry environment, and plantar electric stimulation. ASM was administered twice daily. The pulmonary function was evaluated based on respiration. The mRNA and protein levels of AQPs were estimated by real‐time PCR and Western blot, respectively. Results. MV, TV, the mRNA level of AQP5, and the protein expression of AQP1, AQP4, and AQP5 were increased in ASMCOPD compared to ASSCOPD. Conclusion. The pulmonary function was impaired in ASSCOPD group; the expression of AQP1, AQP4, and AQP5 was decreased at protein and mRNA levels in ASSCOPD group. ASM can improve the pulmonary function in ASSCOPD for MV and TV. ASM could elevate the protein expression of AQP1, AQP4, and AQP5 and the mRNA level of AQP5 in lung tissue.
Effect of Drying Temperature on Iron Fischer-Tropsch Catalysts Prepared by Solvent Deficient Precipitation
Authors: Albretsen Michael K. , Huang Baiyu , Keyvanloo Kamyar , Woodfield Brian F. , Bartholomew Calvin H. , Argyle Morris D. , Hecker William C.
Published: May 2017

A novel solvent deficient precipitation (SDP) method to produce nanoparticles was studied for its potential in Fischer-Tropsch synthesis (FTS) catalysis. Using Fe(NO3)3·9H2O as the iron-containing precursor, this method produces ferrihydrite particles which are then dried, calcined, reduced, and carbidized to form the active catalytic phase for FTS. Six different drying profiles, including final drying temperatures ranging between 80 and 150°C, were used to investigate the effect of ammonium nitrate (AN), a major by-product of reaction between Fe(NO3)3·9H2O and NH4HCO3 in the SDP method. Since AN has two phase-transitions within this range of drying temperatures, three different AN phases can exist during the drying of the catalyst precursors. These AN phases, along with physical changes occurring during the phase transitions, may affect the pore structure and the agglomeration of ferrihydrite crystallites, suggesting possible reasons for the observed differences in catalytic performance. Catalysts dried at 130°C showed the highest FTS rate and the lowest methane selectivity. In general, better catalytic performance is related to the AN phase present during drying as follows: phase III > phase II > phase I. However, within each AN phase, lower drying temperatures led to better catalytic properties.
Custom-Made Alumina Ceramic Total Talar Prosthesis for Idiopathic Aseptic Necrosis of the Talus: Report of Two Cases
Authors: Tonogai Ichiro , Hamada Daisuke , Yamasaki Yuhei , Wada Keizo , Takasago Tomoya , Tsutsui Takahiko , Goto Tomohiro , Sairyo Koichi
Published: May 2017

Two women aged 65 years and 78 years presented to our center with idiopathic necrosis of the talus. In both cases, imaging examinations showed collapse and sclerotic changes of the talar body caused by the necrosis. Both women underwent resection and placement of a third-generation custom-made alumina ceramic total talar prosthesis. Immobilization of the ankle in a short-leg cast for 3 weeks was followed by early rehabilitation. One year and 6 months after surgery, both women were able to walk without pain. Their Japanese Society for Surgery of the Foot ankle-hindfoot scale scores improved from 22 and 29/100 points to 90 and 95/100 points, respectively. To the best of our knowledge, the successful treatments of these two rare cases of idiopathic necrosis of the talus are among only a few reported cases of using a third-generation alumina ceramic prosthesis.
An Exceptional Case of Intraparotid Plexiform Neurofibroma Originating from Autonomic Fibers of the Auriculotemporal Nerve
Authors: Blioskas Sarantis , Sotiriou Sotiris , Rizou Katerina , Koletsa Triantafyllia , Karkos Petros , Kalogera-Fountzila Anna , Markou Konstantinos
Published: May 2017

Plexiform neurofibromas are benign tumors that tend to occur in patients suffering from neurofibromatosis type 1 (NF-1). This report addresses a rare case where the tumor affected the parotid gland, deriving almost exclusively from the peripheral portion of the facial nerve. A 6-year-old male was referred to us complaining about a gradually enlarging swelling over the right parotid area. Imaging localized the lesion to the superficial lobe of the parotid gland, suggesting a neurofibroma. Cosmetic disfigurement and a functional deficit led us to perform complete surgical resection. Meticulous surgical dissection as well as auriculotemporal nerve origin made complete extirpation possible with almost zero morbidity and ensured alleviation of both aesthetic impairment and pain. This is the first case of an intraparotid PN in a pediatric NF-1 patient, which originated from branches of the auriculotemporal nerve and particularly from fibers of the autonomic nervous system. Radical surgical excision was decided according to established decision-making algorithms.
A Systematic Review and Meta-Analysis on the Treatment of Cerebral Hemorrhage with NaoXueShu Oral Liquid
Authors: Wu Lijun , Li Yanda , Wang Xiaofeng , Ren Xiaomeng , Zhu Haiyan , Sun Yikun , Xing Yanwei , Zhu Lingqun , Gao Yonghong , Shang Hongcai
Published: May 2017

NaoXueShu oral liquid invigorates Qi and promotes blood circulation, which is mainly used for treating the acute stage of the meridian of hemorrhagic apoplexy and acute blood stasis syndrome during early convalescence. Its main clinical manifestations include hemiplegia, mouth askew, hemianesthesia, and inarticulateness. It is used mainly in patients with lobar hemorrhage, basal ganglia, and thalamus of the small amount of bleeding without disturbing consciousness of hypertensive cerebral. The purpose of this study was to evaluate the efficacy and adverse effects of NaoXueShu oral liquid on the treatment of cerebral hemorrhage. In this study, literature on randomized controlled trials was collected from seven databases to evaluate the clinical efficiency of the treatment of cerebral hemorrhage alone or combined with Western medicine. The methodologic quality of the included studies was assessed using a standard Cochrane system review and analyzed using RevMan 5.3.0 software. The study included 14 eligible randomized controlled trials. The results showed that the use of NaoXueShu oral liquid alone or combined with other drugs or auxiliary methods can play a significant role in the treatment of cerebral hemorrhage, especially hypertensive intracerebral hemorrhage.
Experimental and Analytical Investigation of Deformations and Stress Distribution in Steel Bands of a Two‐Span Stress‐Ribbon Pedestrian Bridge
Authors: Sandovic G. , Juozapaitis A. , Gribniak V.
Published: May 2017

The article is dedicated to the analysis of problems related to design of pedestrian bridges with flexible ribbon bands made of steel. The study is based on test results of a bridge model that has two spans (each with a length of five meters). A simplified analytical technique has been proposed for predicting vertical deformations of the bridge structure subjected to symmetrical or asymmetrical loading patterns. The technique also allows assessing the tension forces in the ribbons, which are very important for design of such structures. The analysis reveals the importance of the flexural rigidity of the ribbons that might cause significant redistribution of stresses within the steel bands.
Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma
Authors: Wolfe Zachary , Lash Bradley
Published: May 2017

Acquired von Willebrand syndrome (AVWS) is an increasingly recognized entity with numerous potential underlying etiologies. Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Unlike inherited von Willebrand disease (vWD), AVWS tends to present at an older age and without a family history of vWD. Treatment is directed at the underlying etiology if one is uncovered, as well as treatment and prevention of bleeding. Here, we present a rare case of AVWS secondary to Waldenström macroglobulinemia which went unrecognized for several years but resolved promptly with treatment. The potential mechanisms of AVWS secondary to monoclonal gammopathies are discussed as well as strategies to treat and prevent bleeding in these patients.
Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants
Authors: Krenciute Giedre , Prinzing Brooke L. , Yi Zhongzhen , Wu Meng-Fen , Liu Hao , Dotti Gianpietro , Balyasnikova Irina V. , Gottschalk Stephen
Published: May 2017

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and is virtually incurable with conventional therapies. Immunotherapy with T cells expressing GBM-specific chimeric antigen receptors (CAR) is an attractive approach to improve outcomes. Although CAR T cells targeting GBM antigens, such as IL13 receptor subunit α2 (IL13Rα2), HER2, and EGFR variant III (EGFRvIII), have had antitumor activity in preclinical models, early-phase clinical testing has demonstrated limited antiglioma activity. Transgenic expression of IL15 is an appealing strategy to enhance CAR T-cell effector function. We tested this approach in our IL13Rα2-positive glioma model in which limited IL13Rα2-CAR T-cell persistence results in recurrence of antigen-positive gliomas. T cells were genetically modified with retroviral vectors encoding IL13Rα2-CARs or IL15 (IL13Rα2-CAR.IL15 T cells). IL13Rα2-CAR.IL15 T cells recognized glioma cells in an antigen-dependent fashion, had greater proliferative capacity, and produced more cytokines after repeated stimulations in comparison with IL13Rα2-CAR T cells. No autonomous IL13Rα2-CAR.IL15 T-cell proliferation was observed; however, IL15 expression increased IL13Rα2-CAR T-cell viability in the absence of exogenous cytokines or antigen. In vivo, IL13Rα2-CAR.IL15 T cells persisted longer and had greater antiglioma activity than IL13Rα2-CAR T cells, resulting in a survival advantage. Gliomas recurring after 40 days after T-cell injection had downregulated IL13Rα2 expression, indicating that antigen loss variants occur in the setting of improved T-cell persistence. Thus, CAR T cells for GBM should not only be genetically modified to improve their proliferation and persistence, but also to target multiple antigens.

Summary: Glioblastoma responds imperfectly to immunotherapy. Transgenic expression of IL15 in T cells expressing CARs improved their proliferative capacity, persistence, and cytokine production. The emergence of antigen loss variants highlights the need to target multiple tumor antigens. Cancer Immunol Res; 5(7); 571–81. ©2017 AACR.
Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis
Authors: Wu Haoshu , Liu Yunxi , Chen Xiaobing , Zhu Difeng , Ma Jian , Yan Youyou , Si Meimei , Li Xian , Sun Chongde , Yang Bo , He Qiaojun , Chen Kunsong
Published: May 2017

The purpose of this study is to prove the lipid-regulating effects of neohesperidin (NHP) and explore the potential mechanisms related to fibroblast growth factor 21 (FGF21) and AMP-activated protein kinase (AMPK). Free fatty acids (FFAs)-induced lipid-accumulated HepG2 cells, acutely egg yolk-induced dyslipidemia and chronically diet-induced obese (DIO) model mice were treated with NHP. Biochemical analyses were carried out to determine the lipid profiles. Western blotting and real-time PCR were employed to analyze FGF21, AMPK and the related proteins or mRNA expressions. Body weight and food intake were measured in DIO mice. siRNA or inhibitors of FGF21 or AMPK were utilized in further study. NHP showed potent hypolipidemic effect in HepG2 cells loaded with FFAs and reversed the pathological changes of lipid in the acute or chronic dyslipidemia mouse model. It obviously improved the lipid profiles in plasma, liver and gastrocnemius muscles in DIO mice, and led to a significant body weight loss. Simultaneously, FGF21 protein expression or secretion, and AMPK/sirtuin type 1 (SIRT1)/peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) axis or related molecules, was improved by NHP in HepG2 cells and/or DIO mice. Furthermore, the siRNA or inhibitor targeting FGF21 or AMPK rejected the triglyceride-lowering effect of NHP. In conclusion, NHP regulates lipid metabolism in vivo and in vitro via FGF21 and AMPK/SIRT1/PGC-1α signaling axis.
Postoperative Recovery of Light Sensitivity in Eyes with Rhegmatogenous Retinal Detachment
Authors: Ooshiro Tomohiro , Iijima Hiroyuki
Published: May 2017

Purpose: To investigate whether postoperative light sensitivity recovers completely to the level prior to the development of rhegmatogenous retinal detachment (RRD) after successful surgery. Methods: We retrospectively studied 44 eyes of 44 patients with RRD who were successfully operated and who underwent Humphrey central 30-2 perimetry postoperatively. The averaged total deviation in Humphrey perimetry in the reattached retina was compared with that of the horizontal or vertical counterpart in the preoperatively non-detached retina. Results: The averaged total deviation in the reattached retina was significantly lower than in its counterpart (p < 0.0001). The averaged residual loss of light sensitivity did not correlate with postoperative visual acuity (p = 0.8047) or with its change (p = 0.1242). Conclusions: Light sensitivity in the detached retina in eyes with RRD does not completely recover after successful surgery.
The Circulating MicroRNA-206 Level Predicts the Severity of Pulmonary Hypertension in Patients with Left Heart Diseases
Authors: Jin Peng , Gu Wenzhu , Lai Yayu , Zheng Wei , Zhou Qi , Wu Xiaojing
Published: May 2017

Background: MicroRNA-206 (miR-206), a muscle-specific miRNA, regulates the growth of cardiac myocytes and pulmonary artery smooth muscle cells. However, it remains unknown whether miR-206 is involved in pulmonary hypertension (PH) due to left heart diseases (PH-LHD). This study was designed to investigate the correlation between miR-206 and PH in patients with LHD. Methods: In 82 consecutively enrolled LHD patients, we examined the serum levels of miR-206 and analyzed its correlations with pulmonary artery systolic pressure (PASP) and cardiac function. Another 36 age- and sex-matched subjects served as healthy controls. Results: The patients were divided into the LHD group (n=47, PASP<50 mmHg) and the PH-LHD group (n=35, PASP≥50 mmHg). The level of miR-206 was significantly decreased in the PH-LHD group compared with that of the LHD and healthy control groups. In addition, the miR-206 level was correlated with PASP (r=-0.305, p<0.001) but not with systemic blood pressure. Univariate analyses showed that miR-206, brain natriuretic peptide (BNP), left ventricular ejection fraction and left atrial longitudinal diameter (LAD) were significantly related to PASP. Multivariate regression analysis identified miR-206 as an independent predictive factor for PH. MiR-206 alone (cut-off <0.66) demonstrated a sensitivity of 68.60% and a specificity of 65.80% in predicting PH. Moreover, the combination of miR-206, BNP and LAD (cut-off 0.21) showed a sensitivity of 97.10% and a specificity of 80.30% in predicting PH in LHD patients. Conclusion: A decreased circulating miR-206 level was associated with increased PASP in LHD patients. Thus, the level of miR-206, especially combined with BNP and LAD, might be helpful in the detection of PH in LHD patients.
Higher Ultrafiltration Rate Is Associated with Longer Dialysis Recovery Time in Patients Undergoing Conventional Hemodialysis
Authors: Hussein Wael F. , Arramreddy Rohini , Sun Sumi J. , Reiterman Marc , Schiller Brigitte
Published: May 2017

Background: Increased mortality and morbidity are reported in association with high ultrafiltration rate (UFR) and with long dialysis recovery time (DRT). We studied the association between UFR and DRT. Methods: This is a cross-sectional, observational study was conducted. Patients on thrice-weekly hemodialysis (HD) with self-reported DRT between August and December 2014 were included. We examined the association of 30-day average UFR with recovery time. Results: The total number of patients included in this study was 2,689. DRT in categories of immediate recovery, >0-≤2, >2-≤6, >6-≤12, and >12 h, were reported in 27, 28, 17, 9, and 20% of the patients respectively. In multivariable analysis, longer DRT was associated with female gender, non-black race, higher body weight, lower serum albumin, chronic heart failure, cerebrovascular disease, missed dialysis sessions, higher pre-dialysis systolic blood pressure, and larger UF volume. Compared to UFR of <10, UFR ≥13 mL/kg/h was associated with longer DRT, OR of 1.16 (95% CI 0.99-1.36), and 1.28 (95% CI 1.06-1.54) in the unadjusted and the adjusted analyses respectively. Intradialytic hypotension was also associated with longer DRT in the unadjusted (per 10% higher frequency, OR 1.04 [95% CI 1.01-1.07]) and adjusted analyses (OR 1.03 [95% CI 1.00-1.07]). Conclusion: Long recovery time is common after HD. Rapid fluid removal is associated with longer DRT.
Individual Alpha Frequency Relates to the Sound-Induced Flash Illusion
Authors: Keil Julian , Senkowski Daniel
Published: May 2017

Ongoing neural oscillations reflect fluctuations of cortical excitability. A growing body of research has underlined the role of neural oscillations for stimulus processing. Neural oscillations in the alpha band have gained special interest in electrophysiological research on perception. Recent studies proposed the idea that neural oscillations provide temporal windows in which sensory stimuli can be perceptually integrated. This also includes multisensory integration. In the current high-density EEG-study we examined the relationship between the individual alpha frequency (IAF) and cross-modal audiovisual integration in the sound-induced flash illusion (SIFI). In 26 human volunteers we found a negative correlation between the IAF and the SIFI illusion rate. Individuals with a lower IAF showed higher audiovisual illusions. Source analysis suggested an involvement of the visual cortex, especially the calcarine sulcus, for this relationship. Our findings corroborate the notion that the IAF affects the cross-modal integration of auditory on visual stimuli in the SIFI. We integrate our findings with recent observations on the relationship between audiovisual integration and neural oscillations and suggest a multifaceted influence of neural oscillations on multisensory processing.
The Every Student Succeeds Act, State Efforts to Improve Access to Effective Educators, and the Importance of School Leadership
Authors: Fuller Edward J. , Hollingworth Liz , Pendola Andrew
Published: May 2017

Purpose: Our primary purpose is to examine the degree to which state equity plans identify the distribution of principals and principal turnover as factors influencing three leadership mechanisms that affect student access to effective teachers—namely, hiring of teachers, building instructional capacity of teachers, and managing teacher turnover. Research Design: This study relies on document analyses of 52 plans (50 states, Washington, D.C., and Puerto Rico) submitted by states in 2015 to the U.S. Department of Education. These plans included the identification of root causes of the inequitable access to educators within a state as well as proposed solutions to address the inequitable access. Findings: We found that, while 27% of states mentioned the distribution of principals and 48% of states mentioned principal turnover, less than 10% of states connected these two factors to access to effective teachers for each of the three mechanisms. Furthermore, only three states mentioned that principal turnover is associated with teacher turnover and three states discussed that teacher turnover is heavily influenced by the school working conditions created in large part by the principal. Moreover, we found the U.S. Department of Education and most states did not present data on either the inequitable distribution of principals or principal turnover. Finally, we determined that states frequently mention solutions to improving access to effective educators that are unsupported by research under the Every Student Succeeds Act rules of evidence.
‘‘Where People Like Me Don’t Belong’’: Faculty Members from Low-socioeconomic-status Backgrounds
Authors: Lee Elizabeth M.
Published: May 2017

This article examines class as a potential source of stigma faculty members from low-socioeconomic-status (low-SES) backgrounds. Based on 47 interviews with demographically diverse respondents at a wide range of institutions, the article examines respondents’ narratives of direct and indirect stigmatization around class as well as respondents’ efforts at managing these potential stigmas. I find that respondents describe primarily indirect stigmas in which low-SES experiences and concerns are minimized, covered over, or excluded in favor of a normative presentation of middle-class status and experiences. I show the ways that respondents use emotion work to manage both their own responses and the anticipated responses of their colleagues when challenging normative narratives of middle-class homogeneity.
Models of Protection Against Recidivism in Justice-Involved Adults With Mental Illnesses
Authors: Lowder Evan M. , Desmarais Sarah L. , Rade Candalyn B. , Coffey Tim , Van Dorn Richard A.
Published: May 2017

Protective factors may play an important role in the assessment, treatment, and supervision of adult offenders with mental illnesses. However, little is known regarding associations between protective factors, risk factors, and recidivism in this population. In research with adolescents, five models describing these associations have been proposed and tested: (a) Compensatory, (b) Buffer, (c) Challenge, (d) Protective-Protective, and (e) Mediation. This study evaluated these models of protection against recidivism in a sample of justice-involved adults with mental illnesses ( N = 550). Risk and protective factors were operationalized using Short-Term Assessment of Risk and Treatability (START) assessments. Results showed consistent evidence for the Compensatory model, where risk and protective factors were independently associated with recidivism. In contrast, results failed to provide evidence supporting the other four models. Findings underscore the importance of both risk and protective factors in the assessment, treatment, and supervision of adult offenders.
Linking Class and Community
Authors: Fleck Bethany , Hussey Heather D. , Rutledge-Ellison Lily
Published: May 2017

This study contributes to the service learning (SL) literature by providing new empirical evidence of learning from a problem-based SL research project conducted in a developmental research methods course. Two sections of the course taught in a traditional manner were compared to two sections of the course taught with an integrated SL project involving a local Boys & Girls Club. Pre- and posttest scores of the groups were compared in regard to content knowledge, civic engagement, and perceptions of the course. Results indicated that the SL students outperformed the control courses in learning outcomes. Civic engagement did not significantly change over the course of the semester. Student preference data indicated that most enjoyed the SL course, found it helpful, and thought it contributed to their understanding of the course material. The findings are related to past research and theoretical underpinnings that support SL.
Efforts to Privatize the United States Postal Service: Labor’s Response
Authors: Ecker Martha
Published: May 2017

The United States Postal Service (USPS), the second largest employer of civilians in the United States, has been the focus of attempts to restructure the workforce and privatize its activities. The four unions which represent those employed by the USPS have been working together to resist these efforts. Recently, results of arbitration and proposed legislation have given some reason for optimism. The rate of union density within the postal service as well as the potential for private-sector profit making, however, means that it is likely that such struggles will continue.
Household Food Insecurity and Early Childhood Health and Cognitive Development Among Children of Immigrants
Authors: Huang Ying , Potochnick Stephanie , Heflin Colleen M.
Published: May 2017

Food insecurity is negatively related to child development and health. In this study, we use Early Childhood Longitudinal Study–Birth Cohort data to assess the cognitive and health consequences of household food insecurity for children of immigrants compared with children of native-born parents. Results suggest that children of immigrants from food insecure households fare worse than their native peers from food insecure households in health but not in cognitive skills after child and maternal demographic characteristics are taken into account. The remaining health disparity between children in food insecure immigrant households and children in food insecure nonimmigrant households is explained away by immigrant risk and protective factors. Having parents with strong mental health and living in two-parent families partially offset the negative health consequences associated with food insecurity. However, compared with food insecure nonimmigrant children, low socioeconomic risk may exacerbate the negative health consequences of food insecurity among children of immigrants.
Mini-Review: Toxic Tendinopathy
Authors: Bolon Brad
Published: May 2017

Toxic tendinopathy is a rare but reproducible complication in humans, given agents of four drug classes: aromatase inhibitors, fluoroquinolone antibiotics, glucocorticoids (long-term regimens), and statins. Toxic tendinopathy in humans has been linked less consistently to treatment with anabolic steroids, antiretroviral agents (mainly protease inhibitors), metalloproteinase inhibitors (MMPI), and isotretinoin. Classic drug-induced tendinopathies appear as “tendinosis” (i.e., progressive tendon degeneration without inflammation), although cases associated with aromatase inhibitors exhibit mainly tenosynovitis. Any tendon may be affected, but fluoroquinolones, glucocorticoids, and statins most frequently affect large load-bearing tendons in the lower limb, especially the calcaneal (“Achilles”) tendon—which ruptures in approximately 30 to 40% of cases. The time to symptom onset ranges from days (fluoroquinolones) to weeks, months, or even years. The pathogenesis is incompletely understood, but proposed mechanisms include apoptosis of tenoblasts and tenocytes, deficient tenocyte function (leading to abnormal extracellular matrix maintenance and repair as well as disrupted intercellular signaling), and structural disintegration (via a combination of increased expression of lytic enzymes, lessened cholesterol content in cell membranes, and neoangiogenesis within highly ordered tendon tissue). Nonclinical safety assessment of therapeutic candidates in these drug classes should incorporate tendon routinely as a protocol-specified tissue for pathology evaluation.
Longitudinal Analysis Technique to Assist School Leaders in Making Critical Curriculum and Instruction Decisions for School Improvement
Authors: Bigham Gary D. , Riney Mark R.
Published: May 2017

To meet the constantly changing needs of schools and diverse learners, educators must frequently monitor student learning, revise curricula, and improve instruction. Consequently, it is critical that careful analyses of student performance data are ongoing components of curriculum decision-making processes. The primary purpose of this study is to demonstrate the application of panel study longitudinal analysis techniques to inform curricula and instructional improvement efforts using actual data retrieved from state accountability reports of a Texas school district.
Coenzyme Q10 protects skeletal muscle from ischemia-reperfusion through the NF-kappa B pathway
Authors: Boroujeni Mandana Beigi , khayat Zahra Khanipour , Anbari Khatereh , Niapour Ali , Gholami Mohammadreza , Gharravi Anneh mohammad
Published: May 2017

Objective:

Coenzyme Q10 (CoQ10) has antioxidant and anti-inflammatory activity. The aim of this study was to investigate the effects of CoQ10 on the inhibition of nuclear factor-kappa B (NF-κB) activation during ischemia-reperfusion (I/R) of skeletal muscle.

Methods:

For ischemia induction, the animals were anesthetized and the external iliac vessels blocked for three hours. CoQ10 or vehicle was given intraperitoneally during ischemia, just before reperfusion. Four groups received 3,7,14 and 28 days’ reperfusion, respectively, after the intraperitoneal injection of CoQ10 and four corresponding groups received vehicle only. After reperfusion, the gastrocnemius muscles were removed, fixed and stained for the analysis of edema and mast cell infiltration.

Results:

Immuno-histochemistry staining was performed for the detection of tumor necrosis factor alpha (TNF-α) and NF-κB. CoQ10-treated groups showed a significant decrease of mast cell infiltration in the gastrocnemius muscle and edema as compared with the corresponding non-treated groups. Also, CoQ10-treated groups showed a significant TNF-α and NF-κB expression decrease when compared to the corresponding non-treated controls. The results of this study showed CoQ10 administration with ischemia decreased interstitial edema, degeneration of muscle fibers and infiltration of mast cells.

Conclusions:

It seems that CoQ10 has inhibitory effects on NF-κB and TNF-α activation.
Assessment of aflatoxin B1 myocardial toxicity in rats: mitochondrial damage and cellular apoptosis in cardiomyocytes induced by aflatoxin B1
Authors: Ge Junhua , Yu Haichu , Li Jian , Lian Zhexun , Zhang Hongjing , Fang Hao , Qian Lusha
Published: May 2017

Objective

The number of deaths from heart disease is increasing worldwide. Aflatoxin B1 (AFB1), a toxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus, is frequently detected in improperly processed/stored human food products. While AFB1 hepatotoxicity and carcinogenic properties have been well addressed, its myocardial toxicity is poorly documented. This study aimed to investigate myocardial toxic activity of AFB1.

Methods

Ten rats were fed with AFB1 at a dose that did not result in acute toxic reactions for 30 days and 10 vehicle-fed rats served as controls. Transmission electron microscopy was used to assess mitochondrial damage in cardiomyocytes. The terminal deoxynucleotidyl transferase-mediated UTP nick-end labelling assay was performed to detect apoptosis of cardiomyocytes. Western blotting was performed to measure apoptotic proteins (i.e., active caspase-3, Bax, and Bcl-2) in heart tissue.

Results

AFB1 treatment resulted in mitochondrial membrane disruption and disorganization of cristae, which are indicators of mitochondrial damage. Myocardial cell apoptosis was significantly higher after AFB1 treatment (22.07% ± 3.29%) compared with controls (6.27% ± 2.78%, P < 0.05). AFB1 treatment enhanced expression of active caspase-3, Bax, and Bcl-2 in cardiac tissue.

Conclusion

Various adverse effects are exerted by AFB1 on the heart, indicating AFB1 myocardial toxicity.
Comparison of different conservative treatments for idiopathic clubfoot: Ponseti’s versus non-Ponseti’s methods
Authors: He Jin-Peng , Shao Jing Fan , Hao Yun
Published: May 2017

Objective

Various methods are applied in the clinical treatment of idiopathic clubfoot. The purpose of this meta-analysis was to evaluate the efficacy of different conservative treatments.

Methods

Studies were pooled and odds ratio (ORs) with corresponding confidence intervals were calculated for evaluation of the results, relapses, and requirement for major surgery.

Results

A final analysis of 1435 patients from 9 eligible studies was performed. The combined OR indicated that significantly more fair and poor results were achieved and that major surgery was required significantly more often when using non-Ponseti’s methods (OR = 3.33 and OR = 7.32, respectively), but no significant difference was detected in the occurrence of relapse (OR = 1.34). Pooled OR evaluation showed a significantly higher rate of fair and poor results, relapse, and requirement for major surgery when using Kite’s method than when using Ponseti’s method (OR = 3.93, OR = 2.53, and OR = 3.19, respectively), but no significant difference was detected between the French method and Ponseti’s method (OR = 3.01, OR = 0.72, and OR = 1.26, respectively).

Conclusions

This meta-analysis indicates that Ponseti’s method is safe and efficient for conservative treatment of clubfoot and decreases the number of surgical interventions required. It is recommended as the first-choice conservative treatment for idiopathic clubfoot.
The orphanage as an institution of coercive mobility
Authors: Disney Tom
Published: May 2017

This article reconsiders children’s mobilities through the relationship between care and control in the context of Russia’s disability orphanages. Drawing upon the lens of carceral mobilities, the article challenges the dominant conceptualisations of children’s mobilities as ‘independent’ or necessarily intertwined with notions of ‘wellbeing’. Instead this piece draws upon ethnographic research into the Russian disability orphanage system to present three typologies of multi-scalar carceral mobilities which children experience in this context; firstly as a form of spatial segregation and containment, secondly as a form of punishment and finally enforced stillness and restraint as a form of care. In doing so it provides new insights into the nature of the everyday for children in restricted institutional environments, largely absent from the wider geographical literature. Through the lens of carceral mobility this article provides a more nuanced geographical reading of the orphanage beyond an environment variously understood to harm or problematically to provide shelter, but as an institution enmeshed in biopolitical processes of power and control.
Carbon fiber-reinforced polymer composite drilling via aluminum chromium nitride-coated tools: Hole quality and tool wear assessment
Authors: Harris Muhammad , Qureshi Muhammad Asif Mahmood , Saleem Muhammad Qaiser , Khan Sarmad Ali , Bhutta Muhammad Mahmood Aslam
Published: May 2017

Drilling into carbon fiber-reinforced polymer composites presents a stiff challenge in terms of ensuring hole quality aspects such as delamination, roughness, roundness, etc. while maintaining an adequate tool life. The hardened carbon fibers in laid up form generally give rise to chips in powdered form that contribute significantly to tool wear problem. To overcome the aforementioned issues, the use of high performance tools has been reported. This paper reports on the usage of yet another novel high performing but much economical aluminum chromium nitride-coated tools that are typically employed for metallic parts. The effect of aluminum chromium nitride tools at three spindle speeds with constant feed rate was evaluated on hole quality, tool wear, and chip formation pattern of carbon fiber-reinforced polymer composite plates. The results were compared with the performance of conventional high speed steel tools taken as baseline. It was found that the coated tools help significantly improve hole quality and provide appreciable tool life at specific machining parameters.
Thermoelastic fracture behavior of bimodular functionally graded skin-stiffener composite panel with embedded inter-laminar delamination
Authors: Shah Saumya , Panda Saroja Kanta
Published: May 2017

In the present work strain energy release rate as a fracture parameter has been used to evaluate the skin-stiffener debonding in stiffened composite panel with functionally graded (FG) bimodular material property under thermo-mechanical coupled field. The influence of ply lay-up and interaction of residual thermal stresses on the skin-stiffener has been investigated. Stress-dependent elasticity problem of bimodular stiffened panel made up of laminated fiber reinforced polymeric composite is carried out using finite element analysis under various bimodular ratios. The numerical result in terms of compressive load as a function of applied displacement has been compared to the existing literature data to assess the effectiveness of the implemented methodology. Variation of energy release rate along the interface delamination front has been plotted for both mechanical and thermo-mechanical coupled loading with modulus ratio R varying from 1 (unimodular) to 5. Asymmetric variation of energy release rate along the interfacial front has been observed for the bimodular stiffened composite panel.
Fracture behavior of silica nanoparticles reinforced rubber/epoxy composite
Authors: Poonpipat Yanika , Leelachai Kritsanachai , Pearson Raymond A , Dittanet Peerapan
Published: May 2017

Hybrid composites consisting of soft rubber (carboxyl-terminated butadiene acrylonitrile, CTBN) and silica nanoparticles with average particle size of 20 nm were studied for improving toughness of epoxy resins (diglycidyl ether of bisphenol A, DGEBA). The hybrid carboxyl-terminated butadiene acrylonitrile /silica nanoparticles epoxy systems exhibited improvements in the Young’s modulus, and more importantly, fracture toughness (KIC), which can be explained by synergistic impact from the inherent characteristics of each filler. In this study, the highest KIC was reached with addition of small amounts of silica nanoparticles (5 vol.%) to the epoxy containing 15 vol.% carboxyl-terminated butadiene acrylonitrile, where the KIC was distinctly higher than with the epoxy containing carboxyl-terminated butadiene acrylonitrile or silica nanoparticles alone. Cavitation of rubber particles with matrix dilation and particle debonding with subsequent void growth were determined as the toughening mechanisms responsible for the toughness improvements for epoxy. The evidence indicates that debonding of the silica nanoparticles causes a weakening of the matrix–particle interface. The toughness enhancement in hybrid nanocomposites involves an increase in silica nanoparticles particle debonding an increase in plastic zone size, which allows the epoxy matrix to dissipate more fracture energy.
Elastic constants of tapered laminated woven jute/epoxy and woven aloe/epoxy composites under the influence of porosity
Authors: Suthenthiraveerappa Vimalanand , Gopalan Venkatachalam
Published: May 2017

Anisotropic nature of plant fiber and various plant fiber-correlated porosities are the major setbacks in evaluating the elastic constants of plant fiber-reinforced polymer composites theoretically. An attempt is made here to get rid of those setbacks and focuses toward the evaluation of accurate elastic constants of composites. In this work, mechanical characteristics such as tensile, flexure, and shear characteristics of woven jute/epoxy and woven aloe/epoxy composites are determined. The experimentally measured elastic constants of composites are further used to find the elastic anisotropy of the jute and aloe fibers using the proposed model which is a combined model of Halpin–Tsai equations and laminate analogy approach with the inclusion of porosity correction factor. Using the theoretically predicted elastic properties of fiber, the elastic constants of the tapered laminated woven jute/epoxy and woven aloe/epoxy composites are evaluated using the proposed model.
Analysis and testing of polymer matrix composites with thermoplastic liners having enhanced chemical resistance
Authors: Djukic Luke P , Herath Manudha T , Rodgers Daniel C , Sweeting Roderick , Buendia Honesto
Published: May 2017

Polymer matrix composite tanks offer major advantages to the transport industry in terms of increased payload and corrosion resistance compared to conventional steel tanks. Chemical resistance and versatility can be enhanced through the addition of a thermoplastic liner. This paper presents the results of chemical conditioning, testing and analysis of a linear low-density polyethylene liner, on its own and supported by carbon fiber reinforced polymer. Results are compared to ADR (European Agreement Concerning the International Carriage of Dangerous Goods by Road) requirements. The linear low-density polyethylene liner was tested in combination with 12–15% sodium hypochlorite and 98% sulphuric acid. The results indicate that the liner is suitable for service in tanks transporting these two chemicals. Liners were conditioned at 50℃ for periods of 1000 or 2000 h. Shore D hardness tests and three-point bend tests were performed, compared to unconditioned benchmarks, and found to pass ADR requirements. Finite element models were validated and used to facilitate understanding of the failure of the laminates. Predictions indicate that failure load increases with increased liner modulus, yield stress, and thickness. The models also indicate that the laminate strength and modulus is not significantly changed during chemical conditioning for the stated chemicals.
Comparison of silk fibroin electrospun scaffolds with poloxamer and honey additives for burn wound applications
Authors: Kadakia Parin U , Growney Kalaf Emily A , Dunn Andrew J , Shornick Laurie P , Sell Scott A
Published: May 2017

A primary aim in wound-healing research is to construct an inexpensive, biodegradable dermal regeneration template with heightened moisture retention and permeability properties. The presence of moisture is important for optimal burn wound healing as it creates an environment for re-epithelialization and minimizes the risk of infections. Permeability can be achieved through a process known as electrospinning. This scaffold fabrication technique creates a mat of randomly oriented nanofibers that can readily mimic native extracellular matrix. Novel electrospun silk fibroin scaffolds were fabricated with poloxamer 407 (P407) and Manuka honey additives for a burn wound dermal regeneration template application. Enhanced human dermal fibroblast adhesion and cell infiltration were observed with the inclusion of P407, and scaffolds incorporated with Manuka honey demonstrated increased water uptake and a higher cell density within the scaffolds at the end of a 28-day period. Overall, this study established that both the silk fibroin/P407 and silk fibroin/Manuka honey scaffolds have the potential to be successful dermal regeneration templates, with P407 increasing surface wettability and Manuka honey modulating moisture retention.
Identification and imaging of leukemia cells using dual-aptamer-functionalized graphene oxide complex
Authors: Bahreyni Amirhossein , Yazdian-Robati Rezvan , Ramezani Mohammad , Rasouli Mehdi , Alinezhad Nameghi Morteza , Alibolandi Mona , Abnous Khalil , Taghdisi Seyed Mohammad
Published: May 2017

Acute lymphoblastic leukemia is the most common malignancy in children. Patient improvement completely depends on the diagnosis of acute lymphoblastic leukemia. So there is a great demand for diagnosis of acute lymphoblastic leukemia. In this study, a novel assay based on dual-aptamer (Sgc8c and ATP aptamers)-functionalized graphene oxide (DAFGO) complex was designed for the identification of Molt-4 cells (human acute lymphoblastic leukemia T-cell). This assay relies on the internalization of DAFGO complex into Molt-4 cells, but not into U266 cells, using Sgc8c aptamer as molecular recognition probe, and release of FAM-labeled ATP aptamer from the complex in the presence of high amounts of ATP in lysosome, leading to a strong fluorescence emission. Formation of DAFGO complex was analyzed by fluorometric analysis and gel retardation assay. The internalization of complex was monitored by flow cytometry and fluorescence microscopy in Molt-4 (target) and U266 cells (nontarget) with DAFGO complex. Our results showed that the developed complex was efficiently internalized into target cells and induced a strong fluorescence emission.
Cumulative Trauma and Adjustment in Women Exposed to a Campus Shooting: Examining the Role of Appraisals and Social Support
Authors: Boykin Derrecka M. , Dunn Qweandria T. , Orcutt Holly K.
Published: May 2017

Experiencing repeated trauma can have increasingly detrimental effects on psychosocial functioning after subsequent stressors. These effects may be intensified for victims of interpersonal traumas given that these events are often associated with heightened risk for adverse outcomes. To better understand this relationship, the present study prospectively examined the effect of pre-shooting trauma exposure (i.e., interpersonal vs. non-interpersonal trauma) on psychological functioning (i.e., posttraumatic stress symptoms, depression) following a mass campus shooting. Based on previous research, it was expected that negative appraisals and social support would mediate this relationship. A sample of 515 college women reporting prior trauma exposure was assessed at four time points following the shooting (i.e., pre-shooting, 1-month, 6-months, and 12-months post-shooting). Bootstrap analyses with bias-corrected confidence intervals were conducted. Contrary to expectation, pre-shooting trauma exposure was unrelated to 12-month post-shooting outcomes and neither negative appraisals nor social support at 6-months post-shooting emerged as mediators. Interestingly, a history of non-interpersonal trauma was associated with greater post-shooting family and friend support than a history of interpersonal trauma. Ad hoc analyses showed that pre-shooting symptom severity and level of exposure to the shooting had indirect effects on post-shooting outcomes via post-shooting negative appraisals. These findings support that cumulative trauma, regardless of type, may not have an additive effect unless individuals develop clinically significant symptoms following previous trauma. Trauma severity also appears to play a meaningful role.
The Impact of Three Cognitive Training Interventions on Older Adults’ Physical Functioning Across 5 Years
Authors: Ross Lesley A. , Sprague Briana N. , Phillips Christine B. , O’Connor Melissa L. , Dodson Joan E.
Published: May 2017

Objective: Physical functioning is closely associated with cognition. The current study assessed the impact of three cognitive training programs on objective measures of physical functioning across 5 years. Method: Older adults randomized to a processing speed ( n = 702), reasoning ( n = 694), or memory ( n = 703) training intervention were compared with those randomized to a no-contact control condition ( n = 698). Intention-to-treat (ITT) and treatment-received/dosage (time-varying number of training sessions) analyses were conducted. Results: There were no transfer effects in the ITT analyses. Treatment-received models demonstrated that training sessions (i.e., higher dosage) across all intervention arms transferred to better maintained Digit Symbol Copy and Turn 360 performance relative to the control group. More reasoning training transferred to better grip strength. Discussion: This is the first study to demonstrate differential longitudinal cognitive training transfer effects to three performance-based physical functioning measures. Future research should investigate mechanisms of far-transfer effects.