bluuebunny/crossref_metadata_2025 huggingface dataset:
Physiological Benefits of Viewing Nature: A Systematic Review of Indoor Experiments
Authors: Jo Hyunju , Song Chorong , Miyazaki Yoshifumi
Published: November 2019

Contact with nature has been proposed as a solution to achieve physiological relaxation and stress recovery, and a number of scientific verification outcomes have been shown. Compared with studies of the other senses, studies investigating the visual effects of nature have been at the forefront of this research field. A variety of physiological indicators adopted for use in indoor experiments have shown the benefits of viewing nature. In this systematic review, we examined current peer-reviewed articles regarding the physiological effects of visual stimulation from elements or representations of nature in an indoor setting. The articles were analyzed for their stimulation method, physiological measures applied, groups of participants, and outcomes. Thirty-seven articles presenting evidence of the physiological effects of viewing nature were selected. The majority of the studies that used display stimuli, such as photos, 3D images, virtual reality, and videos of natural landscapes, confirmed that viewing natural scenery led to more relaxed body responses than viewing the control. Studies that used real nature stimuli reported that visual contact with flowers, green plants, and wooden materials had positive effects on cerebral and autonomic nervous activities compared with the control. Accumulation of scientific evidence of the physiological relaxation associated with viewing elements of nature would be useful for preventive medicine, specifically nature therapy.
A Retrospective Study about the Differences in Cardiometabolic Risk Indicators and Level of Physical Activity in Bariatric Surgery Patients from Private vs. Public Units
Authors: Rocha de Almeida Rebeca , Cândido de Souza Márcia , Gama de Matos Dihogo , Monteiro Costa Pereira Larissa , Batista Oliveira Victor , Menezes Oliveira Joselina , Soares Barreto-Filho José , Almeida-Santos Marcos , de Souza Raphael , de Freitas Zanona Aristela , Machado Reis Victor , Aidar Felipe , Sobral Sousa Antônio
Published: November 2019

Background: Obesity is a pathology with a growing incidence in developing countries. Objective: To evaluate the evolution of cardiometabolic, anthropometrics, and physical activity parameters in individuals undergoing bariatric surgery (BS) in the public healthcare system (PUS) and private healthcare system (PHS). Methods: A longitudinal, observational, and retrospective study was conducted with 111 bariatric patients on two different health systems, with 60 patients from the PUS and 51 from the PHS. Cardiometabolic risk (CR) was analyzed by the assessment of obesity-related comorbidities (AORC) on admission and 3, 6, and 12 months after BS, and the International Physical Activity Questionnaire (IPAQ) was surveyed before and 12 months after BS. In addition, cardiometabolic risk was also assessed by biochemical (fasting glucose and complete lipidogram) and anthropometric (weight, weight loss, waist circumference, and waist-to-height ratio) parameters. Results: On admission, the parameters of severe obesity, systemic arterial hypertension (SAH), Diabetes mellitus (DM), and waiting time to BS were higher in the PUS. Additionally, in the PUS, AORC was reduced only in the SAH parameter. However, in the post-surgery moment, AORC reduced, and there was no difference between the two groups after BS. Regarding physical activity, the IPAQ showed a higher level of activity in the PHS before and one year after BS. Conclusion: At the PUS, BS is performed in patients with a higher degree of comorbidities, but BS improved the reduction of the CR at a similar level to those observed in the PHS.
Risk Analysis and Extension Assessment for the Stability of Surrounding Rock in Deep Coal Roadway
Authors: Gao Chunjing , Huang Dongmei , Chang Xikun , Xi Han
Published: November 2019

In order to evaluate the surrounding rock stability of deep roadways, the diversity of accident hazard sources in deep coal mining is statistically analyzed. To conduct an effective evaluation, first, the risk analysis of the factors affecting the rock mass accidents is carried out, and the comprehensive safety index system of rock accidents in deep mine roadway is established. Further, combining the theory of hazard sources with the extension method, a matter–element model for the risk assessment of rock mass accidents in deep roadway is established. Finally, the hazard sources for the surrounding rock stability of deep roadway in the E-Zhuang coal mine of Xinwen Ming area are evaluated. The results show that the risk grade of the surrounding rock for deep roadways in E-Zhuang coal mine is “B”, which is generally safe, the human factors and organizational management factors are relatively safe, and some suggestions for improvement are put forward.
Effect of Nutritional Intervention Programs on Nutritional Status and Readmission Rate in Malnourished Older Adults with Pneumonia: A Randomized Control Trial
Authors: Yang Pei-Hsin , Lin Meng-Chih , Liu Yi-Ying , Lee Chia-Lun , Chang Nai-Jen
Published: November 2019

Pneumonia leads to changes in body composition and weakness due to the malnourished condition. In addition, patient family caregivers always have a lack of nutritional information, and they do not know how to manage patients’ nutritional intake during hospitalization and after discharge. Most intervention studies aim to provide nutritional support for older patients. However, whether long-term nutritional intervention by dietitians and caregivers from patients’ families exert clinical effects—particularly in malnourished pneumonia—on nutritional status and readmission rate at each interventional phase, from hospitalization to postdischarge, remains unclear. To investigate the effects of an individualized nutritional intervention program (iNIP) on nutritional status and readmission rate in older adults with pneumonia during hospitalization and three and six months after discharge. Eighty-two malnourished older adults with a primary diagnosis of pneumonia participated. Patients were randomly allocated to either a nutrition intervention (NI) group or a standard care (SC) group. Participants in the NI group received an iNIP according to energy and protein intake requirements in addition to dietary advice based on face-to-face interviews with their family caregivers during hospitalization. After discharge, phone calls were adopted for prescribing iNIPs. Anthropometry (i.e., body mass index, limb circumference, and subcutaneous fat thickness), blood parameters (i.e., albumin and total lymphocyte count), hospital stay, Mini-Nutritional Assessment-Short Form (MNA-SF) score, target daily calorie intake, total calorie intake adherence rate, and three-major-nutrient intakes were assessed during hospitalization and three and six months after discharge. Both groups received regular follow-up through phone calls. Furthermore, the rate of readmission resulting from pneumonia was recorded after discharge. During hospital stay, the NI group showed significant increases in daily calorie intake, total calorie intake adherence rate, and protein intake compared with the SC group (p < 0.05); however, no significant difference was found in anthropometry, blood biochemical values, MNA-SF scores, and hospital stay. At three and six months after discharge, the NI group showed significantly higher daily calorie intake and MNA-SF scores (8.2 vs. 6.5 scores at three months; 9.3 vs. 7.6 scores at six months) than did the SC group (p < 0.05). After adjusting for sex, the readmission rate for pneumonia significantly decreased by 77% in the NI group compared with that in the SC group (p = 0.03, OR: 0.228, 95% CI: 0.06–0.87). A six-month iNIP under dietitian and patient family nutritional support for malnourished older adults with pneumonia can significantly improve their nutritional status and reduce the readmission rate.
A Distributed Storage and Access Approach for Massive Remote Sensing Data in MongoDB
Authors: Wang Shuang , Li Guoqing , Yao Xiaochuang , Zeng Yi , Pang Lushen , Zhang Lianchong
Published: November 2019

With the rapid development of earth-observation technology, the amount of remote sensing data has increased exponentially, and traditional relational databases cannot satisfy the requirements of managing large-scale remote sensing data. To address this problem, this paper undertakes intensive research of the NoSQL (Not Only SQL) data management model, especially the MongoDB database, and proposes a new approach to managing large-scale remote sensing data. Firstly, based on the sharding technology of MongoDB, a distributed cluster architecture was designed and established for massive remote sensing data. Secondly, for the convenience in the unified management of remote sensing data, an archiving model was constructed, and remote sensing data, including structured metadata and unstructured image data, were stored in the above cluster separately, with the metadata stored in the form of a document, and image data stored with the GridFS mechanism. Finally, by designing different shard strategies and comparing MongoDB cluster with a typical relational database, several groups of experiments were conducted to verify the storage performance and access performance of the cluster. The experimental results show that the proposed method can overcome the deficiencies of traditional methods, as well as scale out the database, which is more suitable for managing massive remote sensing data and can provide technical support for the management of massive remote sensing data.
LiDAR and UAV System Data to Analyse Recent Morphological Changes of a Small Drainage Basin
Authors: Borrelli Luigi , Conforti Massimo , Mercuri Michele
Published: November 2019

In this paper, the preliminary results of an integrated geomorphological study carried out in a 1.6 ha catchment area located on the eastern side of the Crati River valley (northern Calabria, South Italy) have been presented. An orthophoto and shaded relief map of the study catchment, obtained by 288 unmanned aerial vehicle (UAV) images, integrated with field geomorphological surveys have been used to produce a detailed map of landslides and water erosion phenomena. The study area is characterized by active morphodynamic processes that result in the occurrence of water erosion phenomena and several landslides. In particular, 29 slides and 37 earth slides that evolve into earth flows have been recognized. Spatial and temporal development of geomorphic processes (erosion/depletion and sedimentation/accumulation) have affected the catchment area in the last seven years. Indeed, the comparison between light detection and ranging digital terrain models (LiDAR-DTM) of 2012 and UAV-DTM of 2019 showed depletion values between −0.01 and –5.76 m, with a mean value of −0.96 m; whereas for the accumulation the mean value is 0.94 m, with a maximum thickness of the deposited material of about 2.98 m. The results obtained highlight the usefulness of the methodology to provide detailed information on geomorphic processes and related short-term landscape development in a small drainage basin.
n-Butylamine for Improving the Efficiency of Untargeted Mass Spectrometry Analysis of Plasma Metabolite Composition
Authors: Maslov Dmitry L. , Trifonova Oxana P. , Balashova Elena E. , Lokhov Petr G.
Published: November 2019

A comparative study of the impact of n-butylamine and traditionally used additives (ammonium hydroxide and formic acid) on the efficiency of the electrospray ionization (ESI) process for the enhancement of metabolite coverage was performed by direct injection mass spectrometry (MS) analysis in negative mode. Evaluation of obtained MS data showed that n-butylamine is one of the most effective additives for the analysis of metabolite composition in ESI in negative ion mode (ESI(−)) The limitations of the use of n-butylamine and other alkylamines in the analysis of metabolic composition and a decontamination procedure that can reduce MS device contamination after their application are discussed. The proposed procedure allows the performance of high-sensitivity analysis of low-molecular-weight compounds on the same MS device in both polarities.
Bioactive Glass Applications in Dentistry
Authors: Skallevold Hans Erling , Rokaya Dinesh , Khurshid Zohaib , Zafar Muhammad Sohail
Published: November 2019

At present, researchers in the field of biomaterials are focusing on the oral hard and soft tissue engineering with bioactive ingredients by activating body immune cells or different proteins of the body. By doing this natural ground substance, tissue component and long-lasting tissues grow. One of the current biomaterials is known as bioactive glass (BAG). The bioactive properties make BAG applicable to several clinical applications involving the regeneration of hard tissues in medicine and dentistry. In dentistry, its uses include dental restorative materials, mineralizing agents, as a coating material for dental implants, pulp capping, root canal treatment, and air-abrasion, and in medicine it has its applications from orthopedics to soft-tissue restoration. This review aims to provide an overview of promising and current uses of bioactive glasses in dentistry.
Adenosine Receptor Profiling Reveals an Association between the Presence of Spare Receptors and Cardiovascular Disorders
Authors: Fenouillet Emmanuel , Mottola Giovanna , Kipson Nathalie , Paganelli Franck , Guieu Régis , Ruf Jean
Published: November 2019

Adenosine and its receptors exert a potent control on the cardiovascular system. This review aims to present emerging experimental evidence supporting the existence and implication in cardiovascular disorders of specific adenosinergic pharmacological profiles, conforming to the concept of “receptor reserve”, also known as “spare receptors”. This kind of receptors allow agonists to achieve their maximal effect without occupying all of the relevant cell receptors. In the cardiovascular system, spare adenosine receptors appear to compensate for a low extracellular adenosine level and/or a low adenosine receptor number, such as in coronary artery disease or some kinds of neurocardiogenic syncopes. In both cases, the presence of spare receptors appears to be an attempt to overcome a weak interaction between adenosine and its receptors. The identification of adenosine spare receptors in cardiovascular disorders may be helpful for diagnostic purposes.
Amoxicillin Modulates ApoA-I Transcription and Secretion, Predominantly via PPARα Transactivation Inhibition
Authors: Tayyeb Jehad Z. , Popeijus Herman E. , Mensink Ronald P. , Konings Maurice C.J.M. , Mulders Kim H.R. , Plat Jogchum
Published: November 2019

In a recent human study, we observed that amoxicillin treatment decreased HDL-C concentration. We hypothesize that antibiotics lower the transcription and secretion of ApoA-I, the responsible protein for HDL production. HepG2 and Caco-2 cells were exposed to increasing dose of amoxicillin, penicillin, and streptomycin. Secreted ApoA-I protein and mRNA transcripts were analyzed using ELISA and qPCR, respectively. To unravel underlying mechanisms, KEAP1, CPT1, and CHOP mRNA expressions were determined as well as PPARα transactivation. In HepG2 and Caco-2, amoxicillin decreased ApoA-I transcription and secretion. Effects on ApoA-I expression were clearly there for amoxicillin while no effects were observed for penicillin or streptomycin. KEAP1, CPT1, and CHOP mRNA expressions were reduced by amoxicillin treatments. Moreover, a significant correlation between ApoA-I and CPT1 mRNA expressions was found. Furthermore, amoxicillin lowered PPARα transactivation. All together, these data suggest that inhibited PPARα transactivation is involved in the effects of amoxicillin on ApoA-I. In conclusion, the direct effect of amoxicillin in treated HepG2 and Caco-2 cells was a lower ApoA-I secretion and transcription. Based on evaluating alterations in KEAP1, CPT1, and CHOP mRNA expressions plus PPARα transactivation, we suggest that a reduced PPARα activation is a potential mechanism behind the observed amoxicillin effects on ApoA-I expression.
The Role of SINE-VNTR-Alu (SVA) Retrotransposons in Shaping the Human Genome
Authors: Gianfrancesco Olympia , Geary Bethany , Savage Abigail L. , Billingsley Kimberley J. , Bubb Vivien J. , Quinn John P.
Published: November 2019

Retrotransposons can alter the regulation of genes both transcriptionally and post-transcriptionally, through mechanisms such as binding transcription factors and alternative splicing of transcripts. SINE-VNTR-Alu (SVA) retrotransposons are the most recently evolved class of retrotransposable elements, found solely in primates, including humans. SVAs are preferentially found at genic, high GC loci, and have been termed “mobile CpG islands”. We hypothesise that the ability of SVAs to mobilise, and their non-random distribution across the genome, may result in differential regulation of certain pathways. We analysed SVA distribution patterns across the human reference genome and identified over-representation of SVAs at zinc finger gene clusters. Zinc finger proteins are able to bind to and repress SVA function through transcriptional and epigenetic mechanisms, and the interplay between SVAs and zinc fingers has been proposed as a major feature of genome evolution. We describe observations relating to the clustering patterns of both reference SVAs and polymorphic SVA insertions at zinc finger gene loci, suggesting that the evolution of this network may be ongoing in humans. Further, we propose a mechanism to direct future research and validation efforts, in which the interplay between zinc fingers and their epigenetic modulation of SVAs may regulate a network of zinc finger genes, with the potential for wider transcriptional consequences.
Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability
Authors: Raineri Alice , Fasoli Sabrina , Campagnari Rachele , Gotte Giovanni , Menegazzi Marta
Published: November 2019

Melanoma is a lethal tumor because of its severe metastatic potential, and serine/threonine-protein kinase B-raf inhibitors (BRAFi) are used in patients harboring BRAF-mutation. Unfortunately, BRAFi induce resistance. Therefore, we tested the activity of onconase (ONC), a cytotoxic RNase variant, against BRAFi-resistant cells to re-establish the efficacy of the chemotherapy. To do so, an A375 dabrafenib-resistant (A375DR) melanoma cell subpopulation was selected and its behavior compared with that of parental (A375P) cells by crystal violet, 5-Bromo-2’-deoxyuridine incorporation, and cleaved poly(ADP-ribose) polymerase 1 (PARP1) western blot measurements. Then, nuclear p65 Nuclear Factor kappaB (NF-κB) and IκB kinases-α/β (IKK) phosphorylation levels were measured. Gelatin zymography was performed to evaluate metalloproteinase 2 (MMP2) activity. In addition, assays to measure migration, invasion and soft agar colony formation were performed to examine the tumor cell dissemination propensity. ONC affected the total viability and the proliferation rate of both A375P and A375DR cell subpopulations in a dose-dependent manner and also induced apoptotic cell death. Among its pleiotropic effects, ONC reduced nuclear p65 NF-κB amount and IKK phosphorylation level, as well as MMP2 activity in both cell subpopulations. ONC decreased cell colony formation, migration, and invasion capability. Notably, it induced apoptosis and inhibited colony formation and invasiveness more extensively in A375DR than in A375P cells. In conclusion, ONC successfully counteracts melanoma malignancy especially in BRAFi-resistant cells and could become a tool against melanoma recurrence.
Phosphoserine Functionalized Cements Preserve Metastable Phases, and Reprecipitate Octacalcium Phosphate, Hydroxyapatite, Dicalcium Phosphate, and Amorphous Calcium Phosphate, during Degradation, In Vitro
Authors: Bystrom Joseph Lazraq , Pujari-Palmer Michael
Published: November 2019

Phosphoserine modified cements (PMC) exhibit unique properties, including strong adhesion to tissues and biomaterials. While TTCP-PMCs remodel into bone in vivo, little is known regarding the bioactivity and physiochemical changes that occur during resorption. In the present study, changes in the mechanical strength and composition were evaluated for 28 days, for three formulations of αTCP based PMCs. PMCs were significantly stronger than unmodified cement (38–49 MPa vs. 10 MPa). Inclusion of wollastonite in PMCs appeared to accelerate the conversion to hydroxyapatite, coincident with slight decrease in strength. In non-wollastonite PMCs the initial compressive strength did not change after 28 days in PBS (p > 0.99). Dissolution/degradation of PMC was evaluated in acidic (pH 2.7, pH 4.0), and supersaturated fluids (simulated body fluid (SBF)). PMCs exhibited comparable mass loss (<15%) after 14 days, regardless of pH and ionic concentration. Electron microscopy, infrared spectroscopy, and X-ray analysis revealed that significant amounts of brushite, octacalcium phosphate, and hydroxyapatite reprecipitated, following dissolution in acidic conditions (pH 2.7), while amorphous calcium phosphate formed in SBF. In conclusion, PMC surfaces remodel into metastable precursors to hydroxyapatite, in both acidic and neutral environments. By tuning the composition of PMCs, durable strength in fluids, and rapid transformation can be obtained.
Applying Text Mining for Identifying Future Signals of Land Administration
Authors: Krigsholm Pauliina , Riekkinen Kirsikka
Published: November 2019

Companies and governmental agencies are increasingly seeking ways to explore emerging trends and issues that have the potential to shape up their future operational environments. This paper exploits text mining techniques for investigating future signals of the land administration sector. After a careful review of previous literature on the detection of future signals through text mining, we propose the use of topic models to enhance the interpretation of future signals. Findings of the study highlight the large spectrum of issues related to land interests and their recording, as nineteen future signal topics ranging from climate change mitigation and the use of satellite imagery for data collection to flexible standardization and participatory land consolidations are identified. Our analysis also shows that distinguishing weak signals from latent, well-known, and strong signals is challenging when using a predominantly automated process. Overall, this study summarizes the current discourses of the land administration domain and gives an indication of which topics are gaining momentum at present.
Comparison of Water Resources Policies between Brazil and Italy
Authors: Pasqualetto Antônio , Lo Presti Diego , Rovai Massimo , Muro Aldo
Published: November 2019

The growing need for water has pressured society and governments to focus more on preservation, planning and management of this natural resource, which is fundamental to ecosystems, especially to humans. Therefore, the goal of this study was to analyze the national policies of water resources in Brazil and Italy, searching for aspects that could promote improvement, aiming at the preservation of water sources, guaranteeing satisfactory quantity and quality. In 2019, studies were carried out by environmental agencies of both countries, listing the main disciplinary regulations. Results show that although both countries have different realities, they have similarities in managerial aspects of water resources, with legislation addressing qualitative and quantitative aspects of water, with guiding principles, instruments and actions aimed at the defense of this natural resource.
Atomic Study on Tension Behaviors of Sub-10 nm NanoPolycrystalline Cu–Ta Alloy
Authors: Li Weibing , Wang Xiao , Gao Libo , Lu Yang , Wang Weidong
Published: November 2019

Atomic simulations give a good explanation of the changes in the physical properties of a material. In this work, the tension behaviors of nanopolycrystalline Cu–Ta alloys are investigated through molecular dynamics (MD) simulations, and the influences of several important factors on the mechanical properties of the materials are studied. Firstly, nanopolycrystalline Cu–Ta (10 at %) alloy models with sub-10 nm grains are established by using the method of replacing the grain boundary atoms. Then, the effects of temperature, pressure, and strain rate on the mechanical properties of nanopolycrystalline Cu–Ta alloy are studied, and the elastic modulus and flow strength are obtained. The observations from the simulation results show that the elastic modulus and flow strength increase with the increasing of grain size for sub-10 nm nanopolycrystalline Cu–Ta alloys, and the elastic modulus increases firstly and then stabilizes as the strain rate increases. Finally, according to the evolution of dislocations and twin crystals, the plastic deformation mechanism of nanopolycrystalline Cu–Ta alloy during the stretching process is discussed in depth.
Effects of Composite Warm Mix Additive (CAR) on the Physical and Rheological Performance of Bitumen and the Pavement Performance of Its Concrete
Authors: Zhang Jizhe , Li Peizhao , Sun Changjun , Liang Ming , Li Yuanyuan , Yao Zhanyong , Zhang Xiaomeng
Published: November 2019

Warm mix asphalt received increasing attention in recent years, and this technology aims to increase the fluidity of bitumen in the process of mixing and construction. To characterize the physical and rheological properties of bitumen and the pavement performance of bituminous mixtures, it was modified by a composite additive Rediset. Rediset consists of both the cationic surfactants and organic additive-based rheology modifiers. Commonly used materials such as Pen 60/80 bitumen and bituminous concrete (AC-20) were selected. The results show that Rediset can improve the penetration and softening point of the bitumen, making the bitumen stiffer and harder. All Rediset-modified bituminous concretes are in the same low-temperature performance grade (PG) as the bitumen without Rediset. Although Rediset can decrease the rutting and crack resistance of Rediset-modified bituminous concrete, all the Rediset-modified bituminous concrete with less than 2% Rediset still satisfied the requirement of the maximum bending strain being higher than 2000 με, and the dynamic stability of Rediset-modified bituminous concrete with 3% Rediset was still higher than 1000 cycles/mm. The cationic surfactants in the Rediset can play the role of an anti-stripping agent and improve the adhesion between the interfaces of the aggregate and bituminous binder, which enhances the moisture resistance of Rediset-modified bituminous concrete.
Machinability and Energy Efficiency in Micro-EDM Milling of Zirconium Boride Reinforced with Silicon Carbide Fibers
Authors: Quarto Mariangela , Bissacco Giuliano , D’Urso Gianluca
Published: November 2019

Several types of advanced materials have been developed to be applied in many industrial application fields to satisfy the high performance required. Despite this, research and development of process suited to machine are still limited. Due to the high mechanical properties, advanced materials are often considered as difficult to cut. For this reason, EDM (Electrical Discharge Machining) can be defined as a good option for the machining of micro components made of difficult to cut electrically conductive materials. This paper presents an investigation on the applicability of the EDM process to machine ZrB2 reinforced by SiC fibers, with assessment of process performance and energy efficiency. Different fractions of the additive SiC fibers were taken into account to evaluate the stability and repeatability of the process. Circular pocket features were machined by using a micro-EDM machine and the results from different process parameters combinations were analyzed with respect to material removal, electrode wear and cavity surface quality. Discharges data were collected and characterized to define the actual values of process parameters (peak current, pulse duration and energy per discharge). The characteristics of the pulses were used to evaluate the machinability and to investigate the energy efficiency of the process. The main process performance indicators were calculated as a function of the number of occurred discharges and the energy of a single discharge. The results show interesting aspects related to the process from both the performances and the removal mechanism point of view.
Effects of Different Ion Irradiation on the Contact Resistance of Pd/Graphene Contacts
Authors: Shahzad Kashif , Jia Kunpeng , Zhao Chao , Wang Dahai , Usman Muhammad , Luo Jun
Published: November 2019

The effect of ion-induced defects on graphene was studied to investigate the contact resistance of 40 nm palladium (Pd) contacting on graphene. The defect development was considered and analyzed by irradiating boron (B), carbon (C), nitrogen (N2), and argon (Ar) ions on as-transferred graphene before metallization. The bombardment energy was set at 1.5 keV and ion dose at 1 × 1014 ions/cm2. The defect yields under different ion irradiation conditions were examined by Raman spectroscopy. Although, dissolution process occurs spontaneously upon metal deposition, chemical reaction between metal and graphene is more pronounced at higher temperatures. The rapid thermal annealing (RTA) treatment was performed to improve the Pd/graphene contact after annealing at 450 °C, 500 °C, 550 °C, and 600 °C. The lowest contact resistance of 95.2 Ω-µm was achieved at 550 °C RTA with Ar ion irradiation. We have proved that ion irradiation significantly enhance the Pd/graphene contact instead of pd/pristine graphene contact. Therefore, in view of the contention of results ion induced defects before metallization plus the RTA served an excellent purpose to reduce the contact resistance.
Tensile Strength and Dispersibility of Pulp/Danufil Wet-Laid Hydroentangled Nonwovens
Authors: Deng Chao , Gong R. Hugh , Huang Chen , Zhang Xing , Jin Xiang-Yu
Published: November 2019

Wet-laid hydroentangled nonwovens are widely used for disposable products, but these products generally do not have good dispersibility and can block sewage systems after being discarded into toilets. In this study, both pulp fibers and Danufil fibers are selected as we hypothesize that the high wet strength and striated surface of Danufil fibers would allow us to produce nonwovens with better dispersibility while having enough mechanical properties. The wet strength and dispersibility of nonwovens are systematically studied by investigating the influence of the fiber blend ratio, fiber length, and water jet pressure. The results indicate that the percent dispersion could be as high as 81.3% when the wet strength is higher than 4.8 N, which has been improved greatly comparing the percent dispersion of 67.6% reported before.
Development of Inert, Polymer-Bonded Simulants for Explosives Detection Systems Based on Transmission X-ray
Authors: Vahčič Mitja , Anderson David , Ruiz Osés Miguel , Rarata Grzegorz , Diaconu Gabriela
Published: November 2019

Explosives detection systems (EDS) based on X-ray are used at airports to screen baggage for the presence of explosives. In Europe and the United States, EDS equipment is tested extensively by specialist test centres prior to approval for operational use in airports. Once EDS are installed in airports, however, it can be challenging to test the EDS equipment and verify that it continues to perform at the highest level, because of the impracticality of introducing bulk explosives into civil aviation airports. We have developed inert, non-toxic polymer-bonded simulants and validated them against real explosives using EDS equipment. The accuracy of our simulants is within 1% of the target bulk density, and within 2% of the target effective atomic number, and the materials have a stability of at least 4 years, with an uncertainty of 0.5%. The simulants generate alarms in almost 100% of cases on a wide range of commercial EDS models, and we consider the simulants fit for purpose for use during testing of EDS equipment at airports.
Synthetic Strategies for Dinucleotides Synthesis
Authors: Appy Lucie , Chardet Crystalle , Peyrottes Suzanne , Roy Béatrice
Published: November 2019

Dinucleoside 5′,5′-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies have been developed over the past fifty years to access these compounds, involving enzymatic processes or chemical procedures based either on P(III) or P(V) chemistry. Both solution-phase and solid-support strategies have been developed and are reported here. Recently, green chemistry approaches have emerged, offering attracting alternatives. This review outlines the main synthetic pathways for the preparation of dinucleoside 5′,5′-polyphosphates, focusing on pharmacologically relevant compounds, and highlighting recent advances.
Correlation Between the Water Solubility and Secondary Structure of Tilapia-Soybean Protein Co-Precipitates
Authors: Tan Li , Hong Pengzhi , Yang Ping , Zhou Chunxia , Xiao Dinghao , Zhong Tanjun
Published: November 2019

The secondary structure of a protein has been identified to be a crucial indicator that governs its water solubility. Tilapia protein isolate (TPI), soybean protein isolate (SPI), and tilapia-soybean protein co-precipitates (TSPC3:1, TSPC2:1, TSPC1:1, TSPC1:2, and TSPC1:3) were prepared by mixing tilapia meat and soybean meal at different mass ratios. The results demonstrated that the water solubility of TSPCs was significantly greater than that of TPI (p <0.05). The changes in ultraviolet–visible and near-ultraviolet circular dichroism spectra indicated that the local structure of TSPCs was different from that of TPI and SPI. Fourier transform infrared Spectroscopy revealed the co-existence of TPI and SPI structures in TSPCs. The secondary structures of TSPCs were predominantly α-helix and β-sheet. TSPC1:1 was unique compared to the other TSPCs. In addition, there was a good correlation between the water solubility and secondary structure of TSPCs, in which the correlation coefficients of α-helix and β-sheet were −0.964 (p <0.01) and 0.743, respectively. TSPCs displayed lower α-helix contents and higher β-sheet contents compared to TPI, which resulted in a significant increase in their water solubility. Our findings could provide insight into the structure–function relationship of food proteins, thus creating more opportunities to develop innovative applications for mixed proteins.
Green Chemistry Extractions of Carotenoids from Daucus carota L.—Supercritical Carbon Dioxide and Enzyme-Assisted Methods
Authors: Miękus Natalia , Iqbal Aamir , Marszałek Krystian , Puchalski Czesław , Świergiel Artur
Published: November 2019

Multiple reviews have been published on various aspects of carotenoid extraction. Nevertheless, none of them focused on the discussion of recent green chemistry extraction protocols, especially for the carotenoids extraction from Daucus carota L. This group of bioactive compounds has been chosen for this review since most of the scientific papers proved their antioxidant properties relevant for inflammation, stress-related disorders, cancer, or neurological and neurodegenerative diseases, such as stroke and Alzheimer’s Disease. Besides, carrots constitute one of the most popular sources of carotenoids. In the presented review emphasis has been placed on the supercritical carbon dioxide and enzyme-assisted extraction techniques for the relevant tetraterpenoids. The detailed descriptions of these methods, as well as practical examples, are provided. In addition, the pros and cons of each method and comparison with the standard solvent extraction have been discussed.
Observation of Single Nanoparticle Collisions with Green Synthesized Pt, Au, and Ag Nanoparticles Using Electrocatalytic Signal Amplification Method
Authors: Sundar Sasikala , Kim Ki Jun , Kwon Seong Jung
Published: November 2019

This work describes the tailored design, green synthesis and characterization of noble metal (Pt, Ag and Au) nanoparticles (NPs) using Sapinduss Mukkorossi fruit extract (SMFE) and its signal NP collision signal response, based on the principle of the electrocatatlytic amplication (EA) method. Here, the SMFE can act as both the reducing and the capping agent for the fabrication of noble nanometals. The SMFE-capped NPs was available for the observation of a single NP collision signal. Two general types of current response were observed: a staircase current response for the Pt or Au NPs, and a blip/spike current response for Ag NPs. These results demonstrated that the eco-friendly synthesized SMFE-capped NPs maintained their electrocatalytic activity, therefore they can be used for the single NP experiments and place an arena for future biosensing applications.
Reply to “Comments on the Editor Re: Shi, Zumin, et al. High Chili Intake and Cognitive Function among 4582 Adults: An Open Cohort Study over 15 Years. Nutrients 11.5 (2019): 1183.”
Authors: Shi Zumin , El-Obeid Tahra , Riley Malcolm , Li Ming , Page Amanda , Liu Jianghong
Published: November 2019

We would like to thank Drs [...]
Dietary Determinants of Metabolic Syndrome Parameters Differ by Gender in College Students
Authors: Saltzgiver Sara , Nielson Alexander , Costello Heidi , Baker Adam , Chan Julian , Aguilar David
Published: November 2019

MyPlate is a guidance system for healthier eating choices. In this cross-sectional study, we investigated the influence of MyPlate food group consumption and exercise on metabolic syndrome (MetS) parameters in college students. Participant (n = 462) blood was analyzed using Cholestech for triglycerides (TG), glucose, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). In addition, weight, waist circumference (WC), and blood pressure (BP) were measured. Diet and Wellness Plus was used to compute participant diet records. Regression analysis and a recursive decision tree were made to predict MetS using RStudio (V.1.1.463). BP decision tree predicted high risk of elevated blood pressure with a recall rate of 93.7%. For males; exercise, empty calories, dairy, and protein were main predictors. For females, vegetable and empty calorie consumption were primary determinants. HDL-C decision tree had a recall rate of 91.8% and showed that the main low HDL-C risk determinants for males were; exercise and grain consumption. Conversely, for females; empty calories, grain, and vegetable consumption were the key factors determining low HDL-C risk. This study shows that MyPlate recommendations are valuable to achieve adequate HDL-C and blood pressure and provides insight into the importance of tailoring food intake guidance based on gender.
A Non-Viral Plasmid DNA Delivery System Consisting on a Lysine-Derived Cationic Lipid Mixed with a Fusogenic Lipid
Authors: Martínez-Negro María , Sánchez-Arribas Natalia , Guerrero-Martínez Andrés , Moyá María Luisa , Tros de Ilarduya Conchita , Mendicuti Francisco , Aicart Emilio , Junquera Elena
Published: November 2019

The insertion of biocompatible amino acid moieties in non-viral gene nanocarriers is an attractive approach that has been recently gaining interest. In this work, a cationic lipid, consisting of a lysine-derived moiety linked to a C12 chain (LYCl) was combined with a common fusogenic helper lipid (DOPE) and evaluated as a potential vehicle to transfect two plasmid DNAs (encoding green fluorescent protein GFP and luciferase) into COS-7 cells. A multidisciplinary approach has been followed: (i) biophysical characterization based on zeta potential, gel electrophoresis, small-angle X-ray scattering (SAXS), and cryo-transmission electronic microscopy (cryo-TEM); (ii) biological studies by fluorescence assisted cell sorting (FACS), luminometry, and cytotoxicity experiments; and (iii) a computational study of the formation of lipid bilayers and their subsequent stabilization with DNA. The results indicate that LYCl/DOPE nanocarriers are capable of compacting the pDNAs and protecting them efficiently against DNase I degradation, by forming Lα lyotropic liquid crystal phases, with an average size of ~200 nm and low polydispersity that facilitate the cellular uptake process. The computational results confirmed that the LYCl/DOPE lipid bilayers are stable and also capable of stabilizing DNA fragments via lipoplex formation, with dimensions consistent with experimental values. The optimum formulations (found at 20% of LYCl content) were able to complete the transfection process efficiently and with high cell viabilities, even improving the outcomes of the positive control Lipo2000*.
Does Academic Publishing Lead to Work-Related Stress or Happiness?
Authors: Kubátová Jaroslava
Published: November 2019

The topic of work-related stress and happiness has recently been of interest to science as well as in practice. Work-related stress has negative effects on workers, organizations, and the whole of society, whereas happiness has positive effects. It is therefore important to monitor the wellbeing of workers. This article deals with stress and happiness as related to academic publishing. To answer the research question of whether academic publishing leads to stress or happiness, a narrative analysis was conducted. Narratives from ten Czech academics were collected and analyzed with the use of a categorical-content approach. The categories used are the general causes of work-related stress and happiness as identified in the literature: work overload, ambiguity, conflict, the sense of meaningful work, job satisfaction, and affective organizational commitment. It was found that academic publishing leads to both work-related stress and happiness. However, stress is more prevalent. Not only do academics experience all the general causes of work-related stress, unfortunately they often lack the sources of happiness. Many specific causes of stress and happiness, as well as unhappiness, were discovered in the narratives. Several ways to improve the situation have been suggested. Refining policies in human resources is particularly important if universities wish to retain their academics.
Venture Capital and Industrial Structure Upgrading from the Perspective of Spatial Spillover
Authors: Yao Li , Lu Jie , Sun Pingjun
Published: November 2019

As an emerging financial entity, venture capital has a significant impact on regional development and local production systems. Previous research results pay more attention to the spatial distribution and agglomeration of venture capital but pay less attention to its spatial externality. This paper used the panel data of 31 provincial-level regions in China from 2003 to 2017 to measure the industrial structure upgrading level from the two dimensions of rationalization of industrial structure and upgrading of industrial structure. Based on regional heterogeneity that determines industrial structure upgrading, local effects and externalities of venture capital, and omission factors, this paper constructs spatial econometrics models of venture capital and industrial structure upgrading. Firstly, venture capital and industrial structure upgrading all have obvious spatial autocorrelation and form different agglomeration areas in local areas. Therefore, regional venture capital and industrial structure upgrading are closely related to regional location factors. China’s venture capital has unique spatial attributes. Secondly, venture capital has a significant role in promoting the industrial structure upgrading, although its simulative effect is weak. In addition, in order to further explore the influence mechanism of regional industrial structure upgrading, this paper found the local fixed asset investment level and R&D intensity promoted the upgrading process of local industrial structure at a significant level. The study of this paper has important implications for the formulation of appropriate regional venture investment policies to promote the optimization and upgrading of industrial structures and sustainable development during the transition period of economic development.
Assessing On-Road Emission Flow Pattern under Car-Following Induced Turbulence Using Computational Fluid Dynamics (CFD) Numerical Simulation
Authors: Shi Xueqing , Sun Daniel (Jian) , Fu Song , Zhao Zhonghua , Liu Jinfang
Published: November 2019

Research assessing on-road emission flow patterns from motor vehicles is essential in monitoring urban air quality, since it helps to mitigate atmospheric pollution levels. To reveal the influence of vehicle induced turbulence (VIT) caused by both front- and rear-vehicles on traffic exhaust and verify the applicability of the simplified line source emission model, a Computational Fluid Dynamics (CFD) numerical simulation was used to investigate the micro-scale vehicle pollutant flow patterns. The simulation results were examined through sensitivity analysis and compared with the field measured carbon monoxide (CO) concentration. Conclusions indicate that the vehicle induced turbulence caused by the airflow blocking effect of both front- and rear-vehicles impedes the diffusion of front-vehicle traffic exhaust, compared with that of the rear vehicle. The front-vehicle isosurface with the CO mass fraction of 0.0012 extended to 6.0 m behind the vehicle, while that of the rear-vehicle extends as far as 12.7 m. But for the entire motorcade, VIT is beneficial to the diffusion of pollutants in car-following situations. Meanwhile, within the range of 9 m behind the rear of the lagging vehicle lies a vehicle induced turbulence zone. Furthermore, the influence of vehicle induced turbulence on traffic exhaust flow pattern is obvious within a range of 1 m on both sides of the vehicle body, where the concentration gradient of on-road emission is larger and contains severe mechanical turbulence. As a result, in the large concentration gradient area of the pollutant flow field, which accounts for 99.85% of the total concentration gradient, using the line source models to represent the on-road emission might introduce considerable errors due to neglecting the influence of vehicle induced turbulence. Findings of this study may shed lights on predicting emission concentrations in multiple locations by selecting appropriate on-road emission source models.
Sustainable Harvesting of Cinnamomum burmannii (Nees & T. Nees) Blume in Kerinci Regency, Indonesia
Authors: Menggala Sidi Rana , Vanhove Wouter , Muhammad Dimas Rahadian Aji , Hendri Jon , Speelman Stijn , Van Damme Patrick
Published: November 2019

Cinnamomum burmannii (Nees & T. Nees) Blume is an endemic tree of up to 20 meters tall that grows in the surrounding forest in the Kerinci regency. Cinnamon is one of the most valuable non-timber forest products (NTFP) harvested from Kerinci. The tree is classified as an NTFP based on criteria set out by a regulation of the Indonesian Ministry of Forestry in 2007. As a result, it must be harvested sustainably. Its massive cultivation has caused deforestation in several areas in Kerinci. The objective of this paper is to assess the environmental impacts of continuous C. burmannii harvesting of the bark by clearcutting the whole tree. Intensive clearcutting, slash, and burn posed a significant threat for (wildlife) biodiversity in the habitat of C. burmannii. The study was performed in collaboration with the Institute for Agricultural Technology of Jambi (BPTP) from October 2018–January 2019. A harvester group in Lempur Mudik village was surveyed through a semi-structured questionnaire, focus group discussions, interviews and direct observations on C. burmannii production methods and their impact on forest conservation. We discuss how young farmers can contribute to forest conservation through sustainable harvesting of cinnamon. We conclude by suggesting leverages for forest conservation and by proposing actions from the local and national governments that should be urgently taken to safeguard wildlife biodiversity in the surrounding forest.