bluuebunny/crossref_metadata_2025 huggingface dataset:
Fine Tuning Rigid Body Docking Results Using the Dreiding Force Field: A Computational Study of 36 Known Nanobody-Protein Complexes
Authors: Erman Burak , Hacisuleyman Aysima
Published: January 2023

This paper aims to understand the binding strategies of a
nanobody-protein pair by studying known complexes. Rigid body
protein-ligand docking programs produce several complexes, called
decoys, which are good candidates with high scores of shape
complementarity, electrostatic interactions, desolvation, buried surface
area, and Lennard-Jones potentials. It is not known which decoy
represents the true structure. We studied thirty-seven nanobody-protein
complexes from the Single Domain Antibody Database, sd-Ab DB,
[http://www.sdab-db.ca/](http://www.sdab-db.ca/). For each
structure, a large number of decoys are generated using the Fast Fourier
Transform algorithm of the software ZDOCK. The decoys were ranked
according to their target protein-nanobody interaction energies,
calculated by using the Dreiding Force Field, with rank 1 having the
lowest interaction energy. Out of thirty-six PDB structures, twenty-five
true structures were predicted as rank 1. Eleven of the remaining
structures required Ångstrom size rigid body translations of the
nanobody relative to the protein to match the given PDB structure. After
the translation the Dreiding interaction (DI) energies of all complexes
decreased and became rank 1. In one case, rigid body rotations as well
as translations of the nanobody were required for matching the crystal
structure. We used a Monte Carlo algorithm that randomly translates and
rotates the nanobody of a decoy and calculates the DI energy. Results
show that rigid body translations and the DI energy are sufficient for
determining the correct binding location and pose of ZDOCK created
decoys. A survey of the sd-Ab DB showed that each nanobody makes at
least one salt bridge with its partner protein, indicating that salt
bridge formation is an essential strategy in nanobody-protein
recognition. Based on the analysis of the thirty-six crystal structures
and evidence from existing literature, we propose a set of principles
that could be used in the design of nanobodies.
Correlating the local geometry of welded joints evaluated from 3D-scans with their fatigue strength by probabilistic fracture mechanics
Authors: Schubnell Jan , Konidena Sai Kumar , Jung Matthias , Braun Moritz , Ehlers Sören , Madia Mauro , Kannengießer Thomas , Löschner Daniel
Published: January 2023

Welded joints have a large variation of their geometry and is one
important reason for the comparable large scatter regarding their
fatigue life. This study presents and tests an approach for the
probabilistic fatigue assessment of welded joints based on their
individual local geometry. This approach is adopted from the IBESS
research cluster and combined with previous work regarding the
evaluation of geometrical parameters from 3D-surface scans. The fatigue
life was calculated based on 26 fatigue test series. In this study the
fatigue strength calculated by the IBESS approach tended to be
overestimated in some cases that is mainly related to the
underestimation of the scatter range of the simulated fatigue tests
according to the real results. Geometrical parameters were varied in the
IBESS calculations and showed that no significant influence on the
calculated fatigue strength was determined for weld toe radii
> 2 mm and flank angle > 30°.
Vaginal morphology and position associated with prolapse recurrence after vaginal surgery: a secondary analysis of the DEMAND study
Authors: BOWEN Shaniel T. , MOALLI Pamela A. , Abramowitch Steven , Luchristt Douglas , MEYER Isuzu , Rardin Charles , HARVIE Heidi S. , HAHN Michael E. , MAZLOOMDOOST Donna , IYER Pooja , CARPER Benjamin , GANTZ Marie G.
Published: January 2023

Objective: To identify postoperative vaginal morphology and
position factors associated with prolapse recurrence following vaginal
surgery. Design: Secondary analysis of MRIs of the Defining
Mechanisms of Anterior Vaginal Wall Descent cross-sectional study.
Setting: Eight clinical sites in the US Pelvic Floor Disorders
Network. Population: Women who underwent vaginal mesh
hysteropexy (hysteropexy) with sacrospinous fixation or vaginal
hysterectomy with uterosacral ligament suspension (hysterectomy) for
symptomatic uterovaginal prolapse between April 2013 and February 2015.
Methods: MRIs (rest, strain) obtained 30-42 months after
surgery, or earlier for participants with recurrence who desired
reoperation prior to 30 months, were analyzed. Prolapse recurrence was
defined as prolapse beyond the hymen at strain on MRI. Vaginal
segmentations (at rest) were used to create 3D models placed in a
morphometry algorithm to quantify and compare vaginal morphology
(angulation, dimensions) and position between groups. Main
Outcome Measures: Vaginal angulation (upper, lower, and upper-lower
vaginal angles in the sagittal and coronal plane), dimensions (length,
maximum transverse width, surface area, volume), and position (apex,
mid-vagina) at rest. Results: Of the 82 women analyzed, 12/41
(29%) in the hysteropexy group and 22/41 (54%) in the hysterectomy
group had prolapse recurrence. After hysteropexy, recurrences had a more
laterally deviated upper vagina (p=0.02) at rest than successes. After
hysterectomy, recurrences had a more inferiorly (lower) positioned
vaginal apex (p=0.01) and mid-vagina (p=0.01) at rest than successes.
Conclusions: Vaginal angulation and position were associated
with prolapse recurrence and indicative of vaginal support mechanisms
related to surgical technique and unaddressed anatomical defects. Future
prospective studies in women before and after prolapse surgery may
distinguish these two factors. Funding: Eunice Kennedy Shriver
National Institute of Child Health and Human Development-sponsored
Pelvic Floor Disorders Network (Grant/Award Number: U10 HD054214, U10
HD041267, U10 HD041261, U10 HD069013, U10 HD069025, U10 HD069010, U10
HD069006, U10 HD054215, U01 HD069031); National Institutes of Health
Office of Research on Women’s Health; Boston Scientific Corporation;
National Academies of Sciences, Engineering, and Medicine’s Ford
Foundation Predoctoral Fellowship Program
Markus Gross' Obituary
Authors: Magar Vanesa
Published: January 2023

Markus Sebastian Gross passed away on 25 January 2022, due to the
injuries he sustained during a household accident on 8 January 2022, and
unexpected complications at the treating hospital. In this obituary we
honor his character and his contributions to science and engineering.
Effect of gravity modulation on the stability analysis of viscoelastic dielectric liquids
Authors: Melson Anthony , P.A. Shazia , Sekhar G. N.
Published: January 2023

The paper presents a linear and non-linear study of convection in a
viscoelastic dielectric liquids. The upper convected Jeffrey model, also
known as Oldroyd-B model is used to represent the viscoelasticity. A
modified method of the Venezian type is used to obtain a correction to
the eigenvalue. The Khayat-Lorenz model is derived for the dielectric
liquid with the aid of minimal mode double Fourier series. The classical
Lorenz model is obtained as a limiting case of the present study. The
effect of different parameters on heat transfer is presented. A
comparison of heat transfer in different viscoelastic liquids is also
discussed.
Seismic scattering and absorption properties of Mars estimated through coda analysis on a long-period surface wave of S1222a marsquake
Authors: Onodera Keisuke , Maeda Takuto , Nishida Kiwamu , Kawamura Taichi , Margerin Ludovic , Menina Sabrina , Lognonne Philippe H. , Banerdt William Bruce
Published: January 2023

On May 4 2022, the seismometer on Mars observed the
largest marsquake (S1222a) during its operation. One of the most
specific features of S1222a is the long event duration lasting more than
8 hours from the occurrence, in addition to the clear appearance of body
and surface waves. As demonstrated on Earth, by modeling a long-lasting
and scattered surface wave with the radiative transfer theory, we
estimated the scattering and intrinsic quality factors of Mars
(Q and Q). This study especially
focused on the frequency range between 0.05 - 0.09 Hz, where
Q and Q have not been constrained yet.
Our results revealed that Q = 1000 - 1500 and
Q = 30 - 500. By summarizing the Martian
Q and Q estimated so far and by
comparing them with those of other celestial bodies, we found that,
overall, the Martian scattering and absorption properties showed
Earth-like values.
Recreating observed convection-generated gravity waves from weather radar observations via a neural network and a dynamical atmospheric model
Authors: Kruse Christopher G , Alexander M. Joan , Bramberger Martina , Chattopadhyay Ashesh , Hassanzadeh Pedram , Green Brian , Grimsdell Alison W. , Hoffmann Lars
Published: January 2023

Convection-generated gravity waves (CGWs) transport momentum and energy,
and this momentum is a dominant driver of global features of Earth’s
atmosphere’s general circulation (e.g. the quasi-biennial oscillation,
the pole-to-pole mesospheric circulation). As CGWs are not generally
resolved by global weather and climate models, their effects on the
circulation need to be parameterized. However, quality observations of
GWs are spatiotemporally sparse, limiting understanding and preventing
constraints on parameterizations. Convection-permitting or -resolving
simulations do generate CGWs, but validation is not possible as these
simulations cannot reproduce the forcing convection at correct times,
locations, and intensities.Here, realistic convective diabatic heating, learned from full-physics
convection-permitting Weather Research and Forecasting (WRF)
simulations, is predicted from weather radar observations using neural
networks and a previously developed look-up table. These heating rates
are then used to force an idealized GW-resolving dynamical model.
Simulated CGWs forced in this way did closely resemble those observed by
the Atmospheric InfraRed Sounder in the upper stratosphere. CGW drag in
these validated simulations extends 100s of kilometers away from the
convective sources, highlighting errors in current gravity wave drag
parameterizations due to the use of the ubiquitous single-column
approximation. Such validatable simulations have significant potential
to be used to further basic understanding of CGWs, improve their
parameterizations physically, and provide more restrictive constraints
on tuning \textit{with confidence}.
The presence of computers in Yugoslav popular music of the second half of the 1980s
Authors: Milojkovic Milan
Published: January 2023

This article is the result of my research of Yugoslav pop music discography in the second half of the 1980s, focused on the processes of implementation of digital musical instruments and general-purpose computers into music production - as original sound sources or replacements for acoustic instruments, as well as poetic metaphors and elements of graphic design of record covers. Based on the data available from recording staff listings, interviews with musicians/producers and the listening experience, the paper covers the most prominent examples of aforementioned practices.
On the meaning of the chordophone musical instruments in the scenes of the mocking of Christ in Serbian medieval art
Authors: Gavrilovic Andjela
Published: January 2023

This article examines the sacral meaning of the chordophone musical
instruments in the scenes of the Mocking of Christ in Serbian medieval art
(1166-1459), preserved only in two monumental ensembles - in the church of
Christ Pantokrator in Decani Monastery (1338-1339) and in the church of the
Holy Archangels Gabriel and Michael in Lesnovo (1346-1347). The instruments
in question are one cithara (Byzantine lyre) and one psaltery. Selected
examples of the comparative material, as well as the written sources, prove
that these musical instruments symbolically point to Christ?s suffering.
Serbian medieval poetry: 20th-century literary-historical and theoretical interpretations
Authors: Ivanovic Aleksandra
Published: January 2023

This paper examines how national literary histories written in the twentieth
century define medieval Serbian poetry. Grounded in the canon of Byzantine
liturgical poetry and dedicated to cult practice, hymnography often did not
conform to modern poetic principles, originality, and metrical form.
Formalist approaches to poetry shaped the anthologies of Serbian medieval
literature published in Yugoslavia in the 1960s. The editors transformed
sequences from narrative prose into poetic texts, thus creating medieval
poems. These cases draw attention to the importance of textual criticism and
the social context in defining medieval literary genres. Exploring
hymnography as a linguistic and liturgical event - a poem sung to an engaged
audience - introduces new perspectives on its interpretation.
Remarkable customs (regarding killing of the old men), the collection by Vlastimir Stanimirovic(ASANU EZ 325/12)
Authors: Miljanovic Aleksandra
Published: January 2023

The work represents the description of the collection Remarkable customs
(regarding killing of the old men) by Vlastimir Stanimirovic, which is in
the Ethnographic collection of the Archive of SANU under the number 325/12.
The collection can be determined as a the?matic considering that all of the
telling is referring by theme and motive to lapot or the custom of killing
the old people. By analyzing them, the characteristics of the genre and
intergenre pervasion of these forms of telling, the composition, the
motives, the characters, and also the processes which are found as
characteristic for narration noted in Stanimirovic?s collection are being
determined.
Recognition and treatment of mild cognitive impairment in Serbian general practice
Authors: Kostic Milena , Fisekovic-Kremic Marina , Kis-Veljkovic Mira
Published: January 2023

Introduction/Objective. Mild cognitive impairment (MCI) is a state of progressive cognitive decline, rarely recognized by general practitioners (GPs), which is a reason of late treatment and fast progression towards more serious conditions. The main obstacles for the timely treatment of MCI are lack of diagnostic protocols and clinical guidelines as well as lack of knowledge and disbelief in the pharmacological therapeutic possibilities. The aim of this investigation was to assess level of recognition of MCI symptoms by GPs, and to estimate their perception of distinct risk factors significance for MCI development. Methods. Participants of the ?Days of General Medicine? Conference (Serbia, March 2018), n = 340, completed 12 items questionnaire about recognition and treatment of the MCI patients. We have used descriptive statistics, ?2, Mann?Whitney U tests, binary logistic regression analysis for results presentation, sub-groups comparison, to assess predictors of drug therapy selection, respectively. Results. Study showed GPs recognize diabetes as most important factor for MCI, then hypercholesterolemia, smoking and sedentary behavior, while hypertension and obesity are perceived as less important. Those GPs who estimated diabetes and hypercholesterolemia as more important for all patients are significantly more prone to prescribe symptomatic therapy (pentoxifylline and vinpocetine), p < 0.05 according to ?2 test. Logistic regression analysis regarding therapy predictions showed that years of GP experience is the most important predictor of drug therapy selection (p < 0.01). Conclusion. Results of this investigation pointed a need for MCI education for young physicians, in order to improve diagnosis and treatment of these patients.
What are the tasks of strategic thinking, governance and action within the world social forum according to Immanuel Wallerstein?
Authors: Vratusa-Zunjic Vera
Published: January 2023

This paper reconstructs the answers of Immanuel Wallerstein (1930-2019) on
the tasks of strategic thinking, governance and action within the World
Social Forum needed in order to achieve ?another world?. The main method
used to achieve as much as possible exhaustive reconstruction of
Wallerstein?s answers to the title questions concerning the strategic
thinking, governance and action among the World Social Forum?s members, is
the qualitative content analysis of 500 Wallerstein?s commentaries, from
Commentary No. 1, published on Oct. 1 1998, to Commentary No. 500, published
on July 1 2019, some three months before his death. This paper?s main aim is
to induce like - thinking people within World Social Forum to carry on to
best of their ability strategic thinking, governance and action within the
WSF keeping in mind Wallerstein?s ideas on these themes, over two decades
after the first meeting of WSF in 2001 in Porto Alegre and less than one
year before the next WSF meeting in Mexico.
Dielectric properties of mechanically activated strontium titanate ceramics
Authors: Zivojinovic Jelena , Kosanovic Darko , Blagojevic Vladimir , Pavlovic Vera , Tadic Nenad , Vlahovic Branislav , Pavlovic Vladimir
Published: January 2023

In this study, microstructure evolution and dielectric properties of SrTiO3
ceramic have been investigated, whereby mechanical activation of SrTiO3
powders was used to modify the functional properties of ceramic materials.
Microstructural SEM analysis of SrTiO3 ceramics showed that the increase in
mechanical activation time results in less porous samples. Raman
spectroscopy indicated changes in the broadening and asymmetry of the TO2
mode with a change in the time of mechanical activation. TO2 mode showed a
Fano asymmetry due to its interaction with polarization fluctuations in
polar micro-regions, which are a consequence of the presence of oxygen
vacancies caused by activation. The maximum value of dielectric permittivity
was observed in the sample activated for 10 min. Also, the sample activated
for 10 min exhibits relatively low values of loss tangent, compared to the
other mechanically activated samples, providing the best overall dielectric
performance compared to other samples.
A Guide for Selection of Genetic Instruments in Mendelian Randomization Studies of Type 2 Diabetes and HbA1c: Toward an Integrated Approach
Authors: Garfield Victoria , Salzmann Antoine , Burgess Stephen , Chaturvedi Nish
Published: January 2023

In this study we examine the instrument selection strategies currently used throughout the type 2 diabetes and HbA1c Mendelian randomization (MR) literature. We then argue for a more integrated and thorough approach, providing a framework to do this in the context of HbA1c and diabetes. We conducted a literature search for MR studies that have instrumented diabetes and/or HbA1c. We also used data from the UK Biobank (UKB) (N = 349,326) to calculate instrument strength metrics that are key in MR studies (the F statistic for average strength and R2 for total strength) with two different methods (“individual-level data regression” and Cragg-Donald formula). We used a 157–single nucleotide polymorphism (SNP) instrument for diabetes and a 51-SNP instrument (with partition into glycemic and erythrocytic as well) for HbA1c. Our literature search yielded 48 studies for diabetes and 22 for HbA1c. Our UKB empirical examples showed that irrespective of the method used to calculate metrics of strength and whether the instrument was the main one or included partition by function, the HbA1c genetic instrument is strong in terms of both average and total strength. For diabetes, a 157-SNP instrument was shown to have good average strength and total strength, but these were both substantially lesser than those of the HbA1c instrument. We provide a careful set of five recommendations to researchers who wish to genetically instrument type 2 diabetes and/or HbA1c. In MR studies of glycemia, investigators should take a more integrated approach when selecting genetic instruments, and we give specific guidance on how to do this.
Glucokinase Inhibition: A Novel Treatment for Diabetes?
Authors: Remedi Maria S. , Nichols Colin G.
Published: January 2023

Chronic hyperglycemia increases pancreatic β-cell metabolic activity, contributing to glucotoxicity-induced β-cell failure and loss of functional β-cell mass, potentially in multiple forms of diabetes. In this perspective we discuss the novel paradoxical and counterintuitive concept of inhibiting glycolysis, particularly by targeted inhibition of glucokinase, the first enzyme in glycolysis, as an approach to maintaining glucose sensing and preserving functional β-cell mass, thereby improving insulin secretion, in the treatment of diabetes.
Efficacy of dapagliflozin by baseline diabetes medications: A prespecified analysis from the DAPA-CKD study
Authors: Beernink Jelle M , Persson Frederik , Jongs Niels , Laverman Gozewijn D. , Chertow Glenn M. , McMurray John J. V. , Langkilde Anna Maria , Correa-Rotter Ricardo , Rossing Peter , Sjöström David , Toto Robert D. , Wheeler David C. , Heerspink Hiddo J.L.
Published: January 2023

  

Objective: To determine whether the benefits of dapagliflozin in patients with type 2 diabetes and chronic kidney disease (CKD) in the Dapagliflozin And Prevention of Adverse Outcomes in CKD trial (DAPA-CKD) varied by background glucose-lowering therapy (GLT).

Research Design and Methods: We randomized 4304 adults (including 2906 with type 2 diabetes) with baseline eGFR 25–75 mL/min/1.73m2 and urinary albumin:creatinine ratio 200–5000 mg/g to dapagliflozin 10mg or placebo once daily (NCT03036150). The primary endpoint was a composite of ≥50% eGFR decline, end-stage kidney disease, and kidney or cardiovascular death. Secondary endpoints included a kidney composite endpoint (primary composite endpoint without cardiovascular death), a cardiovascular composite endpoint (hospitalized heart failure or cardiovascular death), and all-cause mortality. In this prespecified analysis, we investigated the effects of dapagliflozin on these and other outcomes according to baseline GLT class or number of GLTs.

Results: The effects of dapagliflozin on the primary composite outcome was consistent across GLT classes and according to the number of GLTs (all interaction P >0.08). Similarly, we found consistent benefit of dapagliflozin compared to placebo on the secondary endpoints regardless of background GLT class or number of GLTs. The same applied to the rate of decline in estimated glomerular filtration rate and safety endpoints. Dapagliflozin reduced the initiation of insulin therapy during follow-up compared to placebo (HR 0.72 (0.54–0.96), P=0.025).

Conclusion: Dapagliflozin reduced kidney and cardiovascular events in patients with type 2 diabetes and CKD across baseline GLT class or classes in combination.
MANUAL DIDÁTICO BRASILEIRO DO QUARTO ANO DO ENSINO FUNDAMENTAL: CONHECIMENTOS AO PROFESSOR PARA ENSINAR MATEMÁTICA
Authors: Piccoli João Pedro , Alencar Edvonete Souza de
Published: January 2023

O livro didático é uma ferramenta amplamente utilizada nas escolas de ensino básico do Brasil. Possui uma diversidade de funções e aborda diferentes conteúdos de cada componente curricular. Todos eles contêm um manual didático, no qual o somente professor possui acesso. Assim, esta pesquisa teve como objetivo identificar como o manual didático brasileiro do quarto ano do Ensino Fundamental aperfeiçoa o conhecimento especializado do professor que ensina a disciplina de Matemática. A compreensão deste conhecimento nos permite identificar as possíveis causas das dificuldades apresentadas pelos alunos ao estudar a disciplina de Matemática, em especial neste ano escolar. A metodologia escolhida para esta pesquisa foi a investigação documental, centrada no manual do livro Matemática Ápis (2017), autoria de Luís Roberto Dante e baseou-se teoricamente em Carrillo et al. (2018), o qual estudou teoricamente o Conhecimento Especializado do Professor de Matemática (MTSK), classificando-o em seis subdomínios principais: Conhecimento de Tópicos Matemáticos (KoT), Conhecimento da Estrutura da Matemática (KSM), Conhecimento da Prática Matemática (KPM), Conhecimento de Características da Aprendizagem de Matemática (KFLM), Conhecimento do Ensino de Matemática (KMT) e Conhecimento de Parâmetros de Aprendizagem da Matemática (KMLS). Ao estudarmos e analisarmos o manual do livro mencionado, classificamos as orientações indicadas aos professores pelos estudos do MTSK. Como resultado, os subdomínios que mais se destacaram foram o KSM e o KMT. Por fim, é interessante ressaltar que, se estudarmos os manuais presentes em outras coleções, outros subdomínios poderão predominar, obtendo resultados diferentes desta pesquisa.
CISG – Convenção de Viena das Nações Unidas sobre Contratos de e Venda Internacional de Mercadorias no ordenamento jurídico e no cenário econômico brasileiro.
Authors: Taba Vaz Paula Akemi
Published: January 2023

O artigo tem como objetivo abordar alguns aspectos envolvendo Convenção de Viena das Nações Unidas sobre Contratos de e Venda Internacional de Mercadorias. Inicialmente, o artigo trata do papel da Convenção na comunidade internacional, bem como sua função de uniformizar o direito sobre a compra e venda internacional e trazer segurança jurídica. Em seguida, o artigo tece comentários a respeito da recepção da Convenção no ordenamento jurídico brasileiro, a sua relação hierárquica no sistema jurídico e quais são as recentes decisões dos Tribunais de Justiça que envolvem a aplicação da Convenção. Por fim, o artigo abarca uma breve análise econômica da CISG.
Reflexões sobre a utilização da Corte Interamericana de Direitos Humanos como Quarta Instância
Authors: SALEME EDSON RICARDO , LAPA Rosilandy Carina Candido , SANTOS THIAGO HENRIQUE DIAS
Published: January 2023

A evolução da vida em sociedade e a compreensão sobre o respeito à dignidade da pessoa humana fez surgir diversos instrumentos de proteção e mecanismos especializados em mediar possíveis violações. Nas Américas, o Sistema Interamericano de proteção dos direitos humanos, possui um órgão jurisdicional de suma importância para a proteção desses direitos: a Corte Interamericana de Direitos Humanos. Ela tem como função receber e julgar demandas que envolvam Estados com alcance regional. O acesso depende do cumprimento de requisitos essenciais de admissibilidade. A questão que se coloca no artigo é se é possível empregar as decisões da Corte como instância de revisão de sentenças nacionais, como uma quarta instância, e a dinâmica causada por essas decisões no âmbito doméstico dos Estados e na esfera internacional. O método é o hipotético-dedutivo e a metodologia bibliográfica e documental. Aqui serão analisados detalhes relevantes que se iniciam na análise e se estendem até a sentença final litígio
Sémiotique et innovation
Authors: Leone Massimo
Published: January 2023

L’article présente d’abord un bref état des lieux relatif aux potentialités de la sémiotique en tant que discipline d’aide à l’innovation. Suit la description et l’analyse d’une pratique innovante spontanée : celle d’un agent de police qu’on voit, à un grand carrefour de la ville de Manille, transformer la gestualité codée associée à sa fonction de contrôle du trafic en une véritable danse à la Michael Jackson, qui resémantise de manière parfaitement inattendue une banale scène de la vie urbaine. De cette description se dégage une série de constantes permettant d’esquisser les prémisses d’une sémiotique de l’innovation : i) l’innovation ne naît jamais de rien mais émerge d’un matériau sémiotique préexistant ; ii) elle résulte du croisement de deux ou plusieurs systèmes sémiotiques ; iii) elle révèle et exploite des affinités structurales jusqu’alors non perçues entre ces systèmes ; iv) elle perturbe les habitudes sémiotiques et pousse à reconfigurer la culture de la société ; v) elle constitue un processus toujours risqué parce que son succès dépend des rapports entre intentio auctoris, intentio operis et intentio lectoris ; vi) si réussie, elle entraîne des effets d’imitation qui la font tomber au rang de platitude.
Considerações acerca da figura do ágroikos em Aristóteles
Authors: Gall Felipe
Published: January 2023

Aristóteles utiliza o adjetivo ágroikos, agreste, para caracterizar dois vícios anônimos, ambos por carência: um referente à virtude da eutrapelía, e outro referente à virtude da temperança. Tal tematização dá a entender que parece se tratar de uma mesma figura, um mesmo caráter, que é avesso tanto aos prazeres necessários do corpo em geral, quanto ao riso, em particular. Sendo assim, surge uma questão que merece exame: por que essa frugalidade dos ágroikoi, elogiada por Aristóteles na Política, caracterizaria vícios? O presente artigo se propõe a responder este problema, defendendo que a solução para tal paradoxo depende de que se compreenda a dimensão profundamente política das virtudes no pensamento aristotélico.
Teologia da criação e criacionismo evolucinário
Authors: Milagres Lucimar
Published: January 2023

A crença em um Deus criador levanta questões profundas e importantes para muitos de nós, especialmente entre religiosos e cientistas. Apresentamos neste trabalho uma teologia da criação que dialoga com a ciência da criação, a biologia evolutiva. Fizemos uma abordagem concisa das origens através de Gênesis 1 a 11, seguindo com enfoques na repercussão teológica do trabalho de Darwin sobre a origem das espécies. Discorremos sobre quatro tipos de criacionismos mais divulgados em nosso meio para, enfim, expor e defender o Criacionismo Evolucionário e sua visão teológica da evolução humana. Esta cosmovisão é uma modalidade do teísmo evolutivo que ressalta a convicção no Deus Triúno como O Criador e entende a evolução biológica como um processo natural, ordenado e sustentado por Deus. Finalizamos com perspectivas de alguns estudiosos sobre o significado existencial da vida humana, do universo e sua relação com a fé cristã. Nossa expectativa é que o esclarecimento de conceitos e a demonstração de dados científicos poderão trazer luz ao debate entre fé e ciência, favorecendo o diálogo e o trabalho colaborativo. Uma vez que o conhecimento é bem compreendido e divulgado, muitos pré-conceitos podem ser desconstruídos. A mente transformada gera novas atitudes, diálogos eficientes e esclarecimentos persuasivos.
Politica e Santitá nel Pensiero di Igino Giordani
Authors: Matiello Suzana Terezinha , Wolff Elias
Published: January 2023

Nella prospettiva dell’intimo legame tra cristologia e antropologia abbiamo scelto come argomento per la nostra ricerca lo studio della figura di Igino Giordani. Vissuto prima e dopo il Concilio Vaticano II, Giordani è stato un grande protagonista di questo periodo carico di tensioni e trasformazioni sociali, culturali e religiose e ha apportato un grande contributo alla società italiana e oltre mettendo, da cristiano, al centro del suo agire Cristo. L’obiettivo di questo articolo é quello di offrire, tramite alcuni scritti di Giordani, una riflessione sul  momento storico che stiamo vivendo, caratterizzato anch’esso da una profonda crisi antropologica e spirituale. La metodologia aplicata in questa ricerca é quella di una analisi su alcuni texti di Igino Giordani. Nella prima parte della ricerca ci dedicheremo al  incontro di Igino Giordani, nel 1948, con Chiara Lubich, fondatrice del Movimento dei Focolari e all’influenza che esso determina nella successiva fase della sua vita. Nella seconda  parte riporteremo alcuni scritti dello stesso Igino Giordani dai quali si può cogliere lo spessore del suo essere  cristiano in ogni ambito della vita sociale e politica. Nella terza parte parlaremo della politica e la morale nella prospettiva  di Igino Giordani.
Avaliação de competências gerenciais: projeto piloto na Diretoria Geral Administrativa do Tribunal de Justiça de Santa Catarina
Authors: Cascais Bruna Fernandes Alves , Lemos Dannyela da Cunha
Published: January 2023

O objetivo é analisar o processo de implantação de um projeto piloto de avaliação de competências gerenciais no TJSC. Trata-se de um estudo de caso, de natureza qualitativa, cuja coleta de dados compreendeu pesquisa bibliográfica, documental e aplicação de questionários. Foram realizadas 354 avaliações relativas a 114 gestores, bem como aplicados questionários paralelos para complementar os dados junto aos colaboradores e aos gestores avaliados. Os resultados apontaram para pontos fortes, tais como o envolvimento dos atores e a clareza da ferramenta de avaliação, mas também trouxeram pontos para melhoria, tais como necessidade de sensibilização e de ampla divulgação do processo.
Panorama de duas décadas da literatura sobre certificação de competências profissionais em saúde
Authors: Montezano Lana , França Joysse Vasconcelos , Santos Udinelli Alves da Silva , Silva Kleuton Izidio Brandão e , Isidro Antonio
Published: January 2023

O artigo descreve o panorama de publicações sobre certificação de competências profissionais em saúde de 2000 até 2020, contemplando características conceituais, metodológicas e práticas. Os dados obtidos da análise de 171 artigos foram submetidos à estatística descritiva e análise de conteúdo. Identificou-se 84 países com experiências em certificação profissional. A maioria das pesquisas foram empíricas (65%), descritivas (91,1%) e qualitativas (44,6%). Propõem-se definição de certificação e recertificação. O requisito para certificação mais adotado foi exame cognitivo. Identificou-se 16 categorias de dificuldades e 15 de benefícios à certificação. Evidencia-se a adoção de certificação profissional como forma de destaque e reconhecimento profissional.
Adaptabilidade de carreira e sucesso na transição universidade-trabalho: estudo prospectivo com medidas repetidas
Authors: Rodrigues Vitória Oliveira , Oliveira Marina Cardoso de
Published: January 2023

A transição universidade-trabalho e o sucesso na carreira são temas de interesse no campo de estudos das carreiras. Esta investigação orientou-se por dois objetivos: analisar a variabilidade da adaptabilidade de carreira em dois momentos diferentes da transição universidade-trabalho, e testar o seu poder preditivo sobre o sucesso na transição-universidade-trabalho. A amostra final foi composta por 72 recém-formados que responderam à pesquisa prospectivamente em dois momentos diferentes da transição. Os resultados evidenciaram a variabilidade significativa da dimensão preocupação com a carreira após a conclusão da graduação e o seu poder explicativo sobre os indicadores de sucesso na transição universidade-trabalho.
DESAFIOS E AS POTENCIALIDADES DO ENSINO REMOTO EMERGENCIAL: UMA ANÁLISE DA EXPERIÊNCIA DO INSTITUTO FEDERAL DO PIAUÍ
Authors: Guimarães Luciana , Torres Caroline , Lima Déborah
Published: January 2023

Este artigo busca discutir o ensino remoto emergencial no Instituto Federal do Piauí, a partir da experiência dos discentes, com vistas a identificar os desafios e as potencialidades desta forma de ensino. O estudo utilizou a abordagem quanti-qualitativa, tendo como instrumento de coleta de dados um questionário online aplicado com 76 alunos dos terceiros anos dos Cursos Técnicos Integrados ao Ensino Médio dos campi Oeiras, Paulistana e Picos. Os resultados obtidos apontaram que os principais desafios para os alunos da Educação Profissional e Tecnológica referem-se ao desenvolvimento de estratégias de ensino que possam facilitar o processo de aprendizagem e que proporcionem o seu engajamento no desenvolvimento das práticas de estudo, somado às adaptações ambientais e psíquicas que se mostraram necessárias à efetivação desse modelo. As potencialidades revelaram que os estudantes conseguem perceber o ensino remoto como necessário ao contexto pandêmico e que, após adaptados, eles puderam desenvolver uma maior autonomia em relação ao seu processo de aprendizagem, ampliar os conhecimentos tecnológicos e desenvolver novas estratégias de estudo. Conclui-se, portanto, que analisar o ensino remoto requer a compreensão de inúmeras variáveis que interferem nesse processo, para que seja possível avançar na tentativa de construir novos caminhos para o processo educacional.
ETHIOPIA: FEDERALISM, PARTY MERGER AND CONFLICTS
Authors:   Department of Political Science, Albion College, Michigan, GEMECHU Milkessa
Published: January 2023

This article has a twin mission: examining the impact of party merger on the federal arrangement and its association with the current conflicts in Ethiopia. The 1995 federal constitution of Ethiopia devolves powers to regional states. Since then, each regional state was fused with its distinct ruling party that created a coalition at the federal level. This state-party fused federal arrangement faced serious challenges with the rise of intra coalition disagreements since 2016 following the protest movements in the country, which further plunged Ethiopia into a devastating civil war since November 2020. This article asks what caused the conflicts. While recognizing the multidimensional roots of the conflicts, this article uses a political party-driven theory of federalism in order to identify the political processes that led to the conflicts. It argues that in a multiethnic federation such as Ethiopia where there is state-party fusion, a ruling party’s metamorphosis from a coalition to a union may not only centralize power but could also result in both de facto merger of that fragile federation and conflicts. Delinking the state from the party through inclusive national negotiations and democratic elections within a federal arrangement might help transition Ethiopia to a stable country. Keywords: Civil war, conflicts, political parties, Ethiopian federalism, Prosperity Party, power centralization, Abiy Ahmed.
NAMIBIA: FORGOTTEN CONFLICT IN THE CAPRIVI STRIP
Authors:   University of Defence, Brno, Czech Republic, KONECNA Lucie
Published: January 2023

The article focuses on the Caprivi conflict that took place in Namibia in 1999. This conflict was a short and low-intensity conflict. Besides, it meets the criteria to be described as a forgotten conflict. This study aims to explain and describe this conflict, to clarify the reasons why the conflict can be described as a forgotten conflict. A public opinion poll was conducted to confirm the hypothesis that this is a forgotten conflict. The results of this public opinion poll together with further media analysis confirm this hypothesis. The second part of the work focuses on the reasons why the conflict was forgotten. Several theories are applied to the case to provide a comprehensive explanation. In practice, it turns out that there are several reasons. Keywords: Caprivi Strip, conflict, forgotten, Namibia, public opinion, violence.
Buprenorphine has a concentration-dependent cytotoxic effect on equine chondrocytes in vitro
Authors: Castro-Cuellar Gabriel , Cremer Jeannette , Liu Chin-Chi , Queiroz-Williams Patricia , Hampton Chiara , Leise Britta Sigrid
Published: January 2023

OBJECTIVE

To investigate the cytotoxic effects of 2 different concentrations of buprenorphine and compare them with bupivacaine and morphine on healthy equine chondrocytes in vitro.

SAMPLE

Primary cultured equine articular chondrocytes from 3 healthy adult horses.

PROCEDURES

Chondrocytes were exposed for 0 and 2 hours to the following treatments: media (CON; negative control); bupivacaine at 2.2 mg/mL (BUPI; positive control); morphine at 2.85 mg/mL (MOR); buprenorphine at 0.12 mg/mL (HBUPRE); or buprenorphine at 0.05 mg/mL (LBUPRE). Chondrocyte viability was assessed using live/dead staining, water-soluble tetrazolium salt-8 (WST-8) cytotoxic assay, LDH assay, and flow cytometry. All continuous variables were evaluated with a mixed ANOVA with treatment, time, and their interactions as the fixed effects and each horse as the random effect.

RESULTS

Buprenorphine showed a concentration-dependent chondrotoxic effect. The viability of chondrocytes was significantly decreased with exposure to HBUPRE and BUPI compared to CON, MOR, and LBUPRE.

CLINICAL RELEVANCE

Negligible chondrotoxic effects were observed in healthy cultured equine chondrocytes exposed to 0.05 mg/mL of buprenorphine, whereas higher concentrations (0.12 mg/mL) showed a marked cytotoxic effect. Based on these results, low concentrations of buprenorphine appear to be safe for intra-articular administration. Further evaluation of this dose in vivo is needed before recommending its clinical use.
Contribution of G.I.S and Remote Sensing for the Risk Mapping of Soil Water Erosion at Saida Province (Western of Algeria)
Authors: Aouadj Sid Ahmed , Degdag Hanane , Hasaoui Okkacha , Nasrallah Yahia , Zouidi Mohamed , Allam Ayoub , Belkacm Nouar , Khatir Hadj
Published: January 2023

Soil water erosion is a major aspect of landscape degradation in sub-wet to semi-arid Mediterranean environments. This problem has not been dealt with in detail in Algeria although it affects large areas. The objective of this study is to develop a methodology using remote sensing, the digital terrain model (DTM) and geographic information systems (GIS) to map areas with a risk of water erosion within the territory of Saida province and to produce a risk map that can be used as a reference document by the local authority. The presented methodology consists to incorporate three factors controlling the erosion: slope, material friability and land use. The resulting erosion risk map shows five areas of vulnerability to water erosion: very low, low, moderate, high and very high. Areas with high and very high risk of erosion cover more than 20% of the mountainous area and are consistent with our field observations. The methodology presented in this study can be generalized to all areas of the foothills of the Tellian Atlas, where erosion risks pose a threat to urban areas. This model is a tool to help implement a soil conservation plan in order to organise the measures to be applied and ensure sustainable soil management.
Two generalizations of dual-complex Lucas-balancing numbers
Authors: Bród Dorota , Szynal-Liana Anetta , Włoch Iwona
Published: January 2023

In this paper, we study two generalizations of dual-complex Lucas-balancing numbers: dual-complex k-Lucas balancing numbers and dual-complex k-Lucas-balancing numbers. We give some of their properties, among others the Binet formula, Catalan, Cassini, d’Ocagne identities.
A short note on Layman permutations
Authors: Hajnal Péter
Published: January 2023

A permutation p of [k] = {1, 2, 3, …, k} is called Layman permutation iff i + p(i) is a Fibonacci number for 1 ≤ i ≤ k. This concept is introduced by Layman in the A097082 entry of the Encyclopedia of Integers Sequences, that is the number of Layman permutations of [n]. In this paper, we will study Layman permutations. We introduce the notion of the Fibonacci complement of a natural number, that plays a crucial role in our investigation. Using this notion we prove some results on the number of Layman permutations, related to a conjecture of Layman that is implicit in the A097083 entry of OEIS.
Dual-Band, EBG-DGS Wearable Antenna for Emergency Services and Responses in WBAN
Authors: Mallavarapu Sandhya , Lokam Anjaneyulu
Published: January 2023

The paper introduces a compact, thin flexible textile antenna integrated with an Electromagnetic Bandgap (EBG) and Defected Ground Structure (DGS) covering the Wireless Local Area Networks (WLAN) bands (2.4-2.485 GHz and 5.1-5.9 GHz) for emergency services and responses. The geometry and configuration of the proposed antenna are made from common clothing jeans fabric, which makes the antenna more flexible, thin, and conformal. A new configuration of EBG structure is developed using Minkowski fractal geometry as base geometry and a DGS with the complementary dumbbell-shaped slot to operate in WLAN standards. The EBG structure is used to isolate the antenna from the human body, whereas the DGS is used to improve the bandwidth and polarization purity. The prototype covers the WLAN bands with gains of 3.37 dBi and 6.47 dBi, a bandwidth of 115.9 MHz, and 398.06 MHz for the specified wireless bands. The integrated antenna demonstrates a Front to Back Ratio (FBR) of 16.77 dB and 32.72 dB, the radiation efficiency of 36.9 % and 73.8 %, and a better cross-polarization level at 2.45 GHz, 5.85 GHz, respectively. The antenna shows a high gain and an efficiency of about 70 % under the various bending scenario. Thus, the anticipated antenna is the most appropriate and potential candidate for wearable applications in various domains.
Investigating cause-and-effect relationships between supply chain 4.0 technologies
Authors: Sharifpour Hojatallah , Ghaseminezhad Yaser , Hashemi-Tabatabaei Mohammad , Amiri Maghsoud
Published: January 2023

The developments of the fourth industrial revolution have caused changes in all areas of society, including production. The changes in production caused by the fourth industrial revolution have also resulted in fundamental changes in the supply chain and have converted it to supply chain 4.0. Organisations must be receptive to supply chain 4.0 to maintain their competitive advantage. Therefore, this study aimed to investigate the relationships among supply chain 4.0 technologies so that, by learning and understanding these connections, industries can pave the way for the implementation of these technologies in their supply chains and use them in problem-solving. The literature review was used to identify the supply chain 4.0 technologies, and the Delphi technique was applied to extract them, including the Internet of Things (IoT), cyber-physical systems, cloud computing, big data, blockchain, artificial intelligence, Radio-frequency Identification (RFID), augmented reality, virtual reality, and simulation. The relationships of supply chain 4.0 technologies were examined using the DEMATEL technique and based on interpretive structural modelling (ISM), their deployment map was drawn. The type of technologies was determined using the MICMAC method. The MICMAC analysis found that the artificial intelligence technology is independent and, based on the findings through the DEMATEL technique, this technology is related to simulation, which belongs to the first level of the interpretive structural modelling technique, and IoT, cloud computing, big data, and blockchain technologies, which are at the second level. Based on the ISM method, RFID, virtual reality, augmented reality and simulation technologies are located at the first level; IoT, cyber-physical systems, cloud computing, big data and blockchain technologies are situated in the second level; and artificial intelligence technology belongs to the third level. According to the related literature, few studies have been conducted on the issues of supply chain 4.0 and the technologies that affect it.
An approach for semi-automated data quality assurance within BIM models
Authors: Cann Steven , Mahamadu Abdul-Majeed , Prabhakaran Abhinesh , Dziekonski Krzysztof , Joseph Rotimi
Published: January 2023

Successful Building Information Modelling (BIM) enabled projects that require large volumes of project data to be embedded within BIM models. However, with this wealth of data, relevance and accuracy have been identified as important issues affecting the BIM performance of the project. Currently, Quality Assurance (QA) in the industry has focused on geometric data, including scrutinising physical and spatial clashes. However, as BIM practices progress in the industry, the requirements for nongeometric model data and their quality have become more necessary. This study aimed to ascertain the feasibility of using visual programming for semi-automating the BIM QA process in a practical case study on using BIM in infrastructure projects. This paper outlines a generic semi-automated QA methodology and its application in a construction project case study. The validity of this method was tested and evaluated in practice through (n=2) workshops. The methodology was implemented within an integrated engineering consultancy, employing visual programming methodology to generate QA summaries and additionally highlight model elements with data quality issues based on a defined set of parameters. Based on the evaluation findings, the proposed process was feasible and provided a pathway for low-cost and low-skill QA of BIM model data within the architecture, engineering and construction (AEC) industry. The paper’s main scientific contribution is a conceptual framework for using visual programming to achieve automatic quality assurance.