bluuebunny/crossref_metadata_2025 huggingface dataset:
In-silico DESIGN SCREENING OF SOME PYRAZOLONE FUSED HETEROCYCLIC ANALOGUES AS HER2 INHIBITORS TARGETING BREAST CANCER
Authors: Sumathy A. , Suresh R. , Gowrishankar N. L.
Published: April 2022

In human breast cancers, the human epidermal development factor receptor-2 is a membrane tyrosine kinase that is overexpressed, and gene amplified. Pyrazolone fused heterocyclic moieties- thiazolidinone, carboxymethyl thiazolidinone, azetidinone are significant DNA-intercalating agents here human epidermal development factor receptor-2 amplification and over expression are linked to tumour cell proliferation and the pathway of instances in breast cancer. Few novel pyrazolone fused heterocyclic analogues are designed by in-silico-technique for their human epidermal development factor receptor-2 inhibition action. Docking patterns of compounds 4A1-4A10 are carried out against human epidermal development factor receptor-2 (PDB id-3RCD) by using Schrodinger suite 2016-2. Molecular docking study for the framed moieties 4A1-4A10 were performed by Glide XP module of Schrodinger suite. The affinity of binding as chosen based on the Glide score. Many compounds were showing good hydrophobic and hydrogen bonding communication and association in order to hinder human epidermal development factor receptor-2. The derivatives 4A1-4A10 have significant glide scores in the scope of -4.476 to - 6.234 compared with the standard Tamoxifen (-7.893). The in-silico screening properties are within the druglikeness. The results proved that this study gave a shred of evidence for the consideration of Pyrazolone fused heterocyclic analogues as potential human epidermal development factor receptor-2 inhibitors. Among the compounds, 4A1-4A10 with significant glide scores may produce significant anti-breast cancer activity and further in-vitro and in-vivo investigations may prove their therapeutic potential. The precursor phenyl hydrazine is reacted with ethylacetoacetate to give 5-methyl-2-phenyl-2,-dihydro-3H-pyrazol-one derivatives. Also, the reactivity of the precursor towards Schiff base derivatives of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-one to give the hetero analogues of thiazolidinone derivatives was studied.
PHYTOCHEMICAL SCREENING, CYTOTOXIC ACTIVITY AND MOLECULAR DOCKING STUDIES OF Eclipta alba LEAVES EXTRACT AGAINST ORAL CANCER
Authors: Jayaraman Lavanya , Shivaji Subhashini , Anandakumar Shanmugam
Published: April 2022

The goal of this research is to identify phytochemical ingredients in the methanol extract of Eclipta alba (E. alba) leaves and assess their cytotoxicity as well as in-silico binding mechanism of action against oral squamous cell carcinoma (OSCC). The GC-MS analysis has confirmed the presence of major phytochemicals like steroids, terpenoids, tannins etc., in the leaf extract of E. alba. The cytotoxicity activity of the extract by MTT assay showed dose-dependent inhibition (96% at 300 µg/ml) towards the oral cancer KB cell line. Molecular docking of important molecules such as palmitic acid, 9, 12-Octadecadienoic-acid, and Stigmasta-3, 5-dien-7-one with target proteins including Akt1 and Akt2 exposed the best binding energy. The leaves extract of E. alba will be an herbal remedy for oral cancer containing potential inhibitors owing to proven its cytotoxicity activity as well has revealed its binding efficacy against target proteins.
Моделювання та генерування системи багатоваріантних задач змістового модуля «Інтегрування функції однієї змінної»
Authors: Корольський Володимир Вікторович , Шокалюк Світлана Вікторівна
Published: April 2022

Метою дослідження є побудова та підготовка до практичного використання математичних моделей систем багатоваріантних задач з інтегрування функції однієї змінної. Задачами дослідження є побудова математичних моделей систем багатоваріантних задач на знаходження невизначеного інтегралу від раціональної функції певного вигляду та обчислення площ параболічних фігур; розробка програмного засобу для їх автоматизованого генерування. Об’єктом дослідження є процес побудови системи багатоваріантних математичних задач. Предметом дослідження є математичні моделі та програмні засоби реалізації систем багатоваріантних задач на знаходження невизначених інтегралів та обчислення площ параболічних фігур. У роботі подано етапи побудови математичних моделей зазначених систем багатоваріантних задач На допомогу викладачам запропоновано програму-генератор задач, який реалізовано у середовищі SageMathCloud. Результати дослідження планується використати на підтримку комп’ютерно-орієнтованого навчання математичного аналізу майбутніх учителів математики.
Тактика игры и технико-тактическая подготовка юных волейболистов
Authors: Рудь І. С.
Published: April 2022

В роботі проведено аналіз умов техніко-тактичної підготовки юних волейболістів.
Позиція студента до організації фізичного виховання
Authors: Марчик В. І. , Порохненко О. В.
Published: April 2022

Активну позицію до занять фізичними вправами має переважна більшість студентів І-ІІ курсів. В організації фізичного виховання у вузі дві третини студентів надають перевагу дисципліні із обов’язковим відвідуванням перед вільним відвідуванням занять у спортивному клубі.
Фізичне виховання як процес управління адаптацією організму до навчального процесу
Authors: Марчик В. І. , Перекопський С. Ю.
Published: April 2022

В студентські роки для молоді характерна наявність ряду несприятливих умов, серед яких психічне та інтелектуальне напруження у зв’язку з сутністю навчальної діяльності, довготривале утримання статичних поз, зниження рухової активності в організації навчального дня тощо. В роботі, якій вивчалася роль фізичних вправ в адаптації студента до вимог середовища, показано, що процес фізичного виховання можна розглядати як процес управління адаптацією організму до впливу факторів зовнішнього середовища і в зв’язку з цим, можлива рекомендація щодо активного використання фізичних вправ з метою адаптації до навчально-виховного процесу студентської молоді.
Динаміка показників захворюваності школярів м. Кривого Рога протягом 2008-2011 рр.
Authors: Афонін А. П. , Барабаш В. М. , Баутіна А. А. , Марчик В. І. , Терещенко А. П.
Published: April 2022

В роботі, якій досліджували характер коливання показників захворюваності школярів з 2008 року до 2011 року, використано показники планових поглиблених медичних оглядів, що організовуються в поліклініках за місцем проживання школярів. Протягом досліджуваного періоду в школярів загальноосвітніх закладів місто Кривого Рогу відмічається збільшення показників загальної частоти захворюваності на 20% та стійка тенденція зменшення показників в порушеннях постави на 30%, а також органів зору, серцево-судинної системи, нирок, ЦНС та ендокринної системи.
Земельні та рослинні ресурси
Authors: Сметана М. Г. , Казаков В. Л.
Published: April 2022

Детально проаналізовано земельні ресурси Криворіжжя, ґрунти, флору регіону. Доведено, що територія Криворіжжя має надзвичайно сприятливий для ведення сільського господарства рельєф. Наголошено, що особливістю Криворіжжя є те, що значна частина потенціальних ресурсів лікарської сировини, їстівних видів росте на забруднених ділянках, що суттєво обмежує її використання.
CrossViT Wide Residual Squeeze-and-Excitation Network for Alzheimer’s disease classification with self attention ProGAN data augmentation
Authors: Kadri Rahma , Bouaziz Bassem , Tmar Mohamed , Gargouri Faiez
Published: April 2022

Efficient and accurate early prediction of Alzheimer’s disease (AD) based on the neuroimaging data has attracted interest from many researchers to prevent its progression. Deep learning networks have demonstrated an optimal ability to analyse large-scale multimodal neuroimaging for AD classification. The most widely used architecture of deep learning is the Convolution neural networks (CNN) that have shown great potential in AD detection. However CNN does not capture long range dependencies within the input image and does not ensure a good global feature extraction. Furthermore, increasing the receptive field of CNN by increasing the kernels sizes can cause a feature granularity loss. Another limitation is that CNN lacks a weighing mechanism of image features; the network doesn’t focus on the relevant features within the image. Recently,vision transformer have shown an outstanding performance over the CNN and overcomes its main limitations. The vision transformer relies on the self-attention layers. The main drawbacks of this new technique is that it requires a huge amount of training data. In this paper, we combined the main strengths of these two architectures for AD classification. We proposed a new method based on the combination of the Cross ViT and Wide Residual Squeeze-and-Excitation Network. We acquired MRI data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Open Access Series of Imaging Studies (OASIS). We also proposed a new data augmentation based on the self attention progressive generative adversarial neural network to overcome the limitation of the data. Our proposed method achieved 99% classification accuracy and outperforms CNN models.
Can Diet Supplements of Macular Pigment of Lutein, Zeaxanthin, and Meso-zeaxanthin Affect Cognition?
Authors: Wang Hongwei , Wang Ge , Billings Rebecca , Li Daniel , Haase Shakaye R. , Wheeler Pariya F. , Vance David E. , Li Wei
Published: April 2022

Background: Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) are collectively called macular pigment. MZ can be converted from L in the macula. In the recent decade, many studies have been performed to investigate the effects for taking carotenoids, especially L and Z or L, Z, and MZ, as diet supplements on human health. Objective: We examined if diet supplements of L + Z or L + Z + MZ have effects on cognitive function in adults. Methods: A systemic literature search was performed in March 2021 with the following keywords: lutein, zeaxanthin, meso-zeaxanthin, cognition, cognitive, and macular pigment. The searched databases included Medline EBSCOhost, Scopus, Elsevier, Cochrane Library, ProQuest, and ClinicalTrials.gov. Findings from eight clinical trials were presented as the strongest evidence on the studied topic. Results: Most studies have found that macular pigments (L + Z) in blood or macula are positively correlated with cognitive performance. As an index of the amount of macular pigments in the brain, macular pigment optical density is related to cognitive performance in adults. In addition, there is an inverse relationship between a higher amount of macular pigment in the blood and lower risk of mild cognitive impairments or Alzheimer’s disease. Based on the findings from the clinical trials, diet supplements of L + Z or L + Z + MZ are associated with improved cognition in adults. Conclusion: The diet supplements of L + Z or L + Z+MZ are associated with better cognitive functioning, which may be via their beneficial effects on the vision.
PD-LGD correlation for the banking lending segment: Empirical evidence from Russia
Authors: Penikas Henry
Published: April 2022

The Bank of Russia is one of the unique banking regulators in the world as it discloses granular reporting information per the existing credit institutions with the available historical track record. Same time the number of banks dramatically declined from above two and a half thousands in 1990s to one thousand in 2010 and to around 350 in 2021. Such information stimulates designing default probability (PD) models for the Russian banks. There is a separate stream of research that studies the amount of negative capital revealed when the Russian bank got its license withdrawn. However, the existing papers have several shortcomings. First, most of them do not account for the structural breaks in data. Second, there is no search for the best fitting model, just a model is offered and the coefficients of interest are interpreted. Third, the best model is poorly interpretable. Forth, the existing models make short-term forecasts. Fifth, there is no a LGD model for Russian banks, though the amount of negative capital upon license withdrawal was considered. Thus, our research objective is to study PD-LGD correlation (PLC) for the Russian banks. To do so, we improve the existing Russian banks PD model and create a respective novel LGD model. We use the homogenous dataset from 2016 to 2021. We find that PLC for Russian banks equals to +22%.
A study on work-life balance in the era of work from home with reference to understanding the change in perceived job satisfaction through statistical analysis
Authors: Neogi Shromona , Jason A. Prince , Selvakumar Angeline
Published: April 2022

Working from anywhere or Working from Home has been prevalent in many developed countries, specifically in the IT sector. Still, the pandemic brought in the wave for such concepts in India, and the people here were not ready for it socially and culturally. As it was an unforeseen and forced situation here in the country, its adaptability raised several questions and issues in the minds of employers and employees. With the shift happening in work culture, which is, working from home due to the pandemic, many changes have crept into the employees’ minds. One such notable arena, which should be addressed for better human resources management and efficiency, is perceived job satisfaction and understanding the employees’ work-life balance amidst these changes. In the study, 90 employees from selected IT companies at various levels are under consideration to understand their perseverance of job satisfaction and work-life balance in and before the change. The stability and the effects of the different attributes on the subject are studied. Statistical tools like Multiple Regression Analysis, Pearson Correlation, and Z-test are used.
Empirical study on understanding online buying behaviour through machine learning algorithms
Authors: Mukherjee Sayantan , Jason A. Prince , Selvakumar Angeline
Published: April 2022

The research study tries to understand teenagers’ online engagement and the behavioral transformation in buying stuff online. The study also tries to ideate the stability of spike in online buying (if any) and its sustainability. Statistical tools like the K-S test, M.L.R. test, Pearson Correlation has been used to justify the study and the usage of machine learning algorithms to construct a predictive model of behaviour and its efficiency. The study will help online retailers understand their sales figures’ stability. It will allow them to strategize their marketing functionalities to make the space more attractive even after the world comes out of the pandemic. The increasing usage of intelligent android devices and relatively cheap data has surged the penetration of online engagements among all the age group peoples. The youngsters are engaging in online stuff hence bringing down a considerable transformation in buying behaviour, pattern, and a collective change in marketers’ approach to strategizing according to the ever-evolving market forces.
GC-MS analysis of Taraxacum officinale flowers and investigation of antimicrobial, anti-pellicle & anti-biofilm activities
Authors: Shumail Hoor , Hassan Tahira , Barkatullah  , Khalid Shah , Akhtar Naveed , Al-Qahtani Ali , Aldahish Afaf , Alqahtani Taha , Alharbi Hanan M. , Gahtani Reem M.
Published: April 2022

Plants synthesize large amount of useful and complex products which have no obvious metabolic and growth functions. These complex materials are said to be as secondary metabolites—phytochemicals which are plants active compounds possessing the potential to inhibit diseases. The purpose of the recent study was to investigate the pharmaceutical values of the flowers of Taraxacum officinale, for antimicrobial, anti-pellicle and anti-biofilm properties. Metanolic extracts with chloroform and n-hexane fractions against selected different bacterial ( E.coli, P.aeruginosa, S.aureus, S.typhi) and fungal ( F.oxysporum, A.niger, A.alternata, A.Terreus) strains were tested and GC-MS, FTIR and HPLC techniques, for detection of various secondary metabolites which are responsible for these activities, were performed. In antimicrobial assay, the result of the methanolic extract and fractions of the flowers was found to be effective against the tested bacterial and fungal strains. The GC-MS and FTIR analysis of chloroform fractions of T. officinale flowers reported the presence of a wide range of phytochemicals and secondery metabolites liable for the biological activities that can be purified in future for the synthesis of noval improved and valuable pharmaceutical products.
Effect of an on-site physical therapy on pain, posture, function and composition, and work-related health status in workers in Korea
Authors: Kwon Il-Ho , Shin Won-Seob
Published: April 2022

BACKGROUND: The incidence of work-related musculoskeletal disease is increasing despite automated manufacturing processes. OBJECTIVE: To examine the effect of a customized on-site exercise program on pain, posture, body function, body composition, and work-related health status of workers at an auto-parts factory. METHODS: Fifty-six participants were randomly divided into one of two groups: experimental (EG), which received a customized exercise program that included manual and exercise therapy from physiotherapy at the workplace; and control (CG), which received customized exercise sheets for a self-directed program at home. The program was performed 3 times per week for 12 weeks. Assessments were performed according to numerical rating scale (NRS), Exbody, Selective Functional Movement Assessment (SFMA), InBody, Short-Form-12 version 2 (SF-12v2), and Work Ability Index (WAI), which were evaluated before and after the program. RESULTS: The EG exhibited significant within-group changes in NRS, Exbody, SFMA, SF-12v2, and WAI; the CG exhibited significant within-group changes only in NRS and SFMA (p < 0.05). There were significant between-group differences in NRS, Exbody, SFMA, and WAI (p < 0.05). CONCLUSIONS: An on-site program including manual and exercise therapy directed by a physiotherapist among workers at an auto-parts manufacturer was effective in improving pain levels, posture, body function, and work-related health status.
Comparison of the Effects of Native and Commercial Probiotic on Gluten Degradation
Authors:   Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran., Rostami Elham , Heidari Reza ,   Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran., Shirzad ‪Mahdieh ,   Department of Microbial Biotechnology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, University of Tehran, College of Science, Tehran, Iran., Motevaseli Elahe ,   Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran., Mazlumi Mohammad Ali ,   Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Published: April 2022

Background and Objectives: The main treatment for celiac disease is a gluten-free diet. Gluten infection occurs in 55%-32% of these patients, which can cause symptoms in these patients. Many patients with celiac disease are dissatisfied with a gluten-free diet and are interested in a non-dietary alternative treatment. Methods: In this study, probiotic samples of local dairy (milk, yogurt, and cheese) from Iran were collected in sterile conditions and after enzymatic extraction using a lysis buffer and a sonication method for enzyme activity of prolyl endopeptidase and aminopeptidase N were evaluated. Results: The highest absorption rate for Z-Gly-Pro-4-nitroanilide substrate that performs the evaluation of prolyl endopeptidase enzyme, respectively, for strains C10-1 (L. pentosus), B6-1 (L. fermentum), C5-2 (L.paracasei), Y5 (L.paracasei) and C11-1 (L. pentosus) and in relation to Leu-p-NA which assesses aminopeptidase N The highest uptake was observed for strains K1 (L. helveticus), B8-2 (L. plantarum), Y5 (L.paracasei), P2-3 and P35 (L. plantarum), respectively. All of the above strains showed significantly different uptake than the negative control containing buffer and substrate (P<0.05). Finally, the 16s rRNA sequence of the isolated strains was registered in NCBI database. Conclusion: The results of the present study showed that number of native Iranian probiotics have effective activity of prolyl endopeptidase and aminopeptidase N which can be used as a selective combination for gluten degradation and to help celiac patients.
Effects of Oleuropein on Depression Caused by Chronic Stress in Mice
Authors:   Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran., Jafari Maedeh , Houshmandi Zahra ,   Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran., Mahmoodi Gelavij ,   Department of Biology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.
Published: April 2022

Background and Objectives: Depression is still one of challenging, and widely encountered disorders with complex etiology. Recently the role of healthy diet and olive oil in ameliorating depression has been claimed. This study was designed to explore the effects of oleuropein on depression induced by chronic stress in mice. Methods: To induce chronic stress Chronic Restraint Stress (CRS) mice immobilizated in restrainer 2 hours; for 2 weeks then an foot electric shock (2 minutes 0.5mA) were used. Mice under chronic stress were randomly divided into 5 groups; including control group (under chronic stress receiving normal saline), intervention groups (under acute stress receiving oleuropein at doses of 7.5, 15 and 30 mg/kg and positive control (under chronic stress receiving diazepam). Then the expression of 6-interleukin (6- IL) and Metabotropic Glutamate Receptor (mGluR1) were measured, Forced Swimming Test (FST) and Tail Suspension Test (TST) were recorded. Results: In CRS mice,at the dose of oleuropein at 15 mg/kg, the duration of immobility significantly reduced in tail suspension test and doses of 15 and 30 mg/kg of oleuropein significantly decreased the immobility time in forced swimming test (P<0.05) Oleuropein also decreased the expression of 6- IL and mGluR1. Conclusion: According to our results, it seems that reducing the expression of 6- IL and mGluR1 may induce the effect of oleuropein on depressive-like behaviors in mice under chronic stress disorder.
Antibacterial Effect of Latex and Aqueous and Hydroalcoholic Extracts of Sonchus Oleraceus L.
Authors:   Department of Medical Laboratory Sciences, School of Paramedical Sciences, Dezful University of Medical sciences, Dezful, Iran., Ghaffaripour Reza , Bargahi Afshar ,   Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran., An'aam Marzieh ,   Central Research Laboratory, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
Published: April 2022

Background and Objectives: Appearance of multidrug-resistant bacteria has created significant clinical problems in treatment of infectious diseases. Sonchus oleraceus plant with many medicinal properties can be a potential source of antibacterial effects. Methods: Aqueous and hydroalcoholic extracts of S. oleraceus were prepared by maceration and antibacterial effect of these extracts as well as latex on Escherichia coli and Staphylococcus aureus were investigated by micro broth dilution method and MIC/ MBC according to CLSI. Results: Minimum lethal concentrations in latex and aqueous and hydroalcoholic extracts for E. coli respectively 7.8, 15.6 and 7.8 mg / ml and for S. aureus, respectively. 3.9, 7.8 and 62.5 mg / ml were obtained. The highest antibacterial effect was observed in plant latex on S. aureus according to the diameter of inhibition zone. Conclusion: This study presents the first results of the antibacterial effects of latex and aqueous and hydroalcoholic extracts of S. oleraceus in Iran. The highest inhibitory effect was related to latex at 3.9 mg / ml on S. aureus. Further studies can help us understand the antimicrobial potential of this plant.
城市燃气应用与实践
Authors:   王磊, 张 秀梅 ,   韩潇
Published: April 2022

城市燃气是现代化城市的标志性基础设施之一，使用燃气可减轻劳动强度、保护环境和节约能源，对于提高城市品位和人民生活质量、改善投资环境、增强地方经济实力有着十分重要的现实意义。城市燃气是一种优质能源，燃气与煤等其它燃料相比具有热效率高、无灰、无渣、燃烧后的有害气体排量少等特点，在农村也正日益得到普及。燃气又是一种易燃、易爆、有毒的气体，如果您认真掌握它的特性并正确地使用，它将给您的家庭带来温暖和幸福；但是若安装和使用不当，它又将会给您的家庭带来不幸，甚至会毁灭您的财产和生命。近年来，尽管我国城市天然气能源发展和利用取得了很大的成绩，但是由于我们起步晚、普及率低，在安全供气、安全运行、有效管理等方面与发达国家相比还有很大差距，特别是供气技术水平和服务水平还满足不了居民不断增长的需求。本着经验共享、成果共用的精神和精炼、科普、实用的原则，作者们编著了《城市燃气应用与实践》一书，以便在生产实践中共同学习、借鉴和应用。 本书叙述了城市燃气的相关知识，分九章，共计约20万字符数：绪论为燃气的基础知识（由韩潇撰写，约5000字符）；第一章为城镇燃气管道安全运行与维护（由张秀梅撰写，约28000字符）；第二章为燃气管道工程施工（由张秀梅撰写，约22000字符）；第三章为燃气工程安全技术与管理（由王磊撰写，约32000字符）；第四章为城市燃气输配工程（由王磊撰写，约18000字符）；第五章为液化石油气（由崔宏亮撰写，约20000字符）；第六章为液化天然气（由韩潇撰写，约35000字符）；第七章为压缩天然气（由刘燕英撰写，约10000字符）；第八章为燃气采购与运输管理（由杨云佳撰写，约20000字符）；第九章为燃气工程造价（由石晓昀撰写，约10000字符）。
¿Cuál es el mejor método de estimación de talla final en pacientes con pubertad precoz?
Authors: Quiroga Daniela , Bruera María José , Vidaurre Josefa , Cerda Jaime , Cattani Andreina , García Hernán
Published: April 2022

La pubertad precoz central consiste en una activación prematura del eje hipotálamo-hipófisis-gonadal, lo que produce una fusión temprana del cartílago de crecimiento y, en muchos casos, una talla inferior al objetivo genético. Un adecuado pronóstico de estatura final es fundamental para definir el tratamiento. Objetivo: Comparar la concordancia de la talla final utilizando la predicción de la estatura efectuada por dos métodos validados versus la talla diana o talla objetivo genético, en niñas que consultaron por pubertad precoz central. Pacientes y Método: estudio retrospectivo de cohorte no concurrente en el que participaron 93 niñas con pubertad precoz central no tratadas con análogos de LHRH y que alcanzaron su talla final. Los datos iniciales se obtuvieron de sus fichas clínicas. Para predecir la talla se aplicaron los métodos más utilizados en la práctica clínica, Bayley-Pinneau y RocheWainer-Thissen, y luego se compararon los resultados con la talla objetivo genético. La concordancia entre la talla final estimada y la talla final obtenida se evaluó mediante el método de Bland y Altman. Resultados: Al comparar la talla final obtenida con la predicha por el método de Bayley-Pinneau se observó una diferencia promedio de 1,01 cm. Mediante el método de Roche-Wainer-Thissen, se observó una diferencia de +0,96 cm. El cálculo de la talla objetivo genético, arrojó una diferencia de +0,05 cm respecto a la talla final. Conclusión: La predicción de estatura realizada por los métodos Bayley-Pinneau y Roche-Wainer-Thissen fue adecuada, y contrario a lo esperado, fue similar al cálculo de la talla objetivo genético que no utiliza la edad de maduración ósea. Esta además presentó mejor concordancia y menor dispersión de los resultados respecto a la talla final obtenida.
СТАНОВЛЕННЯ ІНСТИТУТУ ЗВЕРНЕНЬ ГРОМАДЯН ЯК КОНСТИТУЦІЙНОГО МЕХАНІЗМУ РЕАЛІЗАЦІЇ ПРАВ І СВОБОД ЛЮДИНИ В УКРАЇНІ
Authors: Кравцов Максим Олександрович
Published: April 2022

Мета роботи. У статті розглянуто основні проблеми становлення інституту звернень громадян до органів державної влади в Україні як конституційного механізму реалізації прав та свобод людини і громадянина.Методологія. Застосовано інструментарій порівняльно-функціонального аналізу стану наукової бази та визначено зв’язок між розглядом звернень громадян органами державної влади і розвитком громадянського суспільства.Наукова новизна. Обґрунтовано, що для ефективного функціонування інституту звернень громадян необхідний певний рівень політичної і правової культури як власне громадян, так і чиновників. Охарактеризовано зарубіжний досвід у функціонуванні та безперервному розвитку громадянського суспільства, його відносин із владними структурами, їхнього демократичного контролю, а також нарощування суспільної інституційної спроможності.Визначено проблеми діяльності України щодо функціонування інституту звернень громадян до органів державної влади та обґрунтовано, що актуальність цього напряму досліджень у галузі публічного управління та адміністрування зумовлена потребою ефективного регулювання соціальних процесів, аби їх розвиток не набув некерованого характеру та своєю чергою не призвів до небажаних соціальних деформацій. Розглянуто понятійно-категоріальний апарат інституту звернень та наведено основні тлумачення терміна «звернення», доступні в науковій та методичній літературі.Надано власне визначення поняття «звернення» як способу, за допомогою якого громадяни в усній або письмовій формі ініціюють спілкування з державними органами або посадовими особами для того, аби задовольнити власні інтереси шляхом вирішення владою питань суспільного характеру завдяки реагуванню цих органів або посадових осіб на звернення.Висновки. Зроблено висновок, що розвиток інституту звернення громадян відбувається в рамках міжнародно-правового регулювання захисту прав людини і основних свобод та є конституційним механізмом захисту таких прав і свобод, а також механізмом зворотного зв’язку владно-суспільної взаємодії в процесах публічного врядування.
УДОСКОНАЛЕННЯ МЕХАНІЗМУ ДЕРЖАВНОГО УПРАВЛІННЯ ТРАНСФОРМАЦІЄЮ ТУРИСТИЧНОЇ ГАЛУЗІ НА ОСНОВІ ІННОВАЦІЙНИХ ТЕХНОЛОГІЙ
Authors: Любчук Ольга Костянтинівна , Ярченко Юлія Віталіївна
Published: April 2022

В умовах глобалізації людської діяльності та впровадження цифрових технологій відбуваються трансформаційні процеси у сфері обслуговування, з’являються нові види туризму, нові потреби та послуги, все це потребує удосконалення державного управління туристичною галуззю. Мета роботи. Визначити структурні складові частини механізму державного управління туристичною галуззю в умовах пандемії та цифровізації економіки. Методологія. До теоретико-методологічних передумов розв’язання даної проблеми можна віднести такі роботи науковців: «Проблема розвитку ринку кваліфікацій для туріндустрії в Україні» (Любчук О.К., Ярченко Ю.В. Вісник), «Комбінаторика алгоритму Форда-Фулкерсона для зниження ризиків пандемії COVID-19 у міжнародному туризмі» (Sharko M., Fomishyna V., Liubchuk O., Petrushenko N., Yakymchuk T), «Методичне забезпечення управління підтриманням фінансових потоків зовнішнього туризму в глобальних ризикованих умовах» (Sharko M., Liubchuk O., Fomishyna V., Yarchenko Y., Fedorova N., Petrushenko N., Ohorodnyk R.), «Туризм як сучасна детермінанта суб’єктивної задоволеності життям в Україні» (Любчук О.К.), «Концептуально-стратегічні засади цільового механізму державного управління суб’єктивною задоволеністю життям українських громадян» (Любчук О.К., Ярченко Ю.В. Менеджер). Наукова новизна полягає у з’ясуванні теоретико-методологічних засад функціонування та розвитку механізму державного управління. Висновки. Удосконалення державного управління туристичною галуззю в умовах цифровізації економіки повинно включати розробку цільового механізму, кадрового механізму, функціонального механізму, правового механізму, інструментального механізму, організаційного механізму, фінансового механізму та механізму управління інноваційним розвитком.
ЗДОРОВ’ЯЗБЕРЕЖУВАЛЬНІ МЕХАНІЗМИ ДЛЯ РОЗБУДОВИ ОСВІТНЬОГО ПРОСТОРУ УКРАЇНИ: ДЕРЖАВНО-УПРАВЛІНСЬКИЙ КОНТЕКСТ
Authors: Олексієнко Олександра Миколаївна
Published: April 2022

Мета роботи. Метою статті є здійснення ґрунтовного аналізу встановлення сутності механізмів державного управління створення здоров’язбережувального освітнього простору в Україні.Методологія. У запропонованій статті проаналізовані поняття вдосконалення, реформування, оптимізації й інтенсифікації в освіті, ефективність і готовність керівних кадрів до управління впровадженням сучасних методик здоров’язбережувальних технологій, організації освітнього простору та його вплив на якість життєдіяльності всіх суб’єктів закладу освіти: безпеки життя, створення здоров’язбережувального освітнього простору, формування іміджу закладу освіти, екологічної культури, здоров’я. Узагальнено різні підходи до визначення змісту та структури поняття «механізм державного управління».Наукова новизна. Проаналізовано використання терміна «механізми державного управління» у стратегічних документах щодо розвитку системи освіти. Запропоновано визначення та структурну модель механізму державного управління розвитком загальної середньої освіти.Висновки. Механізми державного управління підготовкою кадрів для створення здоров’язбережувального освітнього простору можуть бути розбудовані на основі гуманістичної тріади сучасної філософії освіти «людина – освіта – екологія – педагогічна культура». Необхідним є створення дієвих механізмів державно-громадського управління системою освіти як шляхом утворення нових інститутів, так і шляхом удосконалення діяльності вже наявних. Доцільним є створення при державних органах управління низки експертних рад – постійно діючих дорадчих органів, функціонування яких підвищить рівень участі працедавців закладів освіти, громадських і професійних об’єднань у виробленні рішень із найважливіших питань створення державних механізмів здоров’язбережувального простору освіти України.
Effect of Mulch Type and Application of Liquid Organic Fertilizer on Pumpkin Plants (Cucurbita moschata)
Authors: Ummah Robithotul , Rinadi Maydella Vista Putri
Published: April 2022

The production of pumpkin (Cucurbita moschata Durch) continues to increase. Optimize the production results, a special treatment is needed. The treatment can be in the form of cultivation techniques such as giving mulch or applying appropriate fertilizers. Research is located on Jl. Kaping Gajah No.45, Jatimulyo Village, Lowokwaru District, Malang City. Observation of parameters: observing the length of the tendrils, number of leaves, number of flowers, fruit weight, diversity of arthropods and intensity of disease in plants. The effect of using black silver plastic mulch (BSPM) is more influential on plant growth and yield than the treatment of black mulch and straw mulch. This is BSPM can suppress weed growth, maintain soil water balance, increase soil surface temperature, increase microorganism activity, keep soil loose, and stimulate root growth. The observations it can be seen that the use of liquid organic fertilizer (LOF) has more effect on plant growth and yield than without using LOF. This is because the use of LOF can stimulate the growth of production branches, and increase the formation of flowers and ovules, and reduce the fall of leaves, flowers and ovules. The use of BSPM and LOF will optimize the growth and yield of pumpkin plants. When use of BSPM and LOF, the soil will remain loose, the activity of soil microorganisms will increase, and the nutrients in the soil will also be maintained.
Analysis Morphological Character and Relationship of Suweg (Amorphophallus campanulatus) Plant in Jombang District
Authors: Saputro Muhammad Ega , Qomariah Umi Kulsum Nur , Faizah Mazidatul
Published: April 2022

Suweg is one of the tuber-producing plants in Jombang. Suweg plants in Jombang have not been cultivated regularly, but actually, suweg tubers have great potential to be used as food diversification material in the future. The development of suweg plants, for example assembling varieties has not been done much. The first step in assembling varieties that must be done is germplasm exploration. This study aims to obtain information on the suweg plant in Jombang, to find out the differences in plant characteristics and the kinship relationship of the suweg plant in the same sub-district or in different sub-districts. The research was carried out in Jombang district, covering the Districts of Wonosalam, Kesamben, Ngusikan, Together, Kudu and Plandaan. The location selection is determined based on the results of the preliminary survey. The research was conducted from April to June 2020. The data analysis used a descriptive method, namely simplifying and organizing the data to obtain an overall picture of the object being observed. In addition to the use of descriptive analysis, kinship analysis was carried out using cluster data analysis. In the kinship analysis, the similarity matrix was calculated manually, while the dendrogram was made using NTSys software. The results obtained 9 plant samples from 6 locations. Two samples from Wonosalam location 1 and Wonosalam location 2 , One sample from Kesamben location 1 , One sample from Ngusikan location 1 , Three samples from joint location 1 , Together with location 2 , Together with location 3 , One sample from Kudu location 1 and one sample from Location plan 1 . Kinship analysis showed various relationships with a similarity matrix value of 0.52 – 1.00, this indicates that the diversity of suweg plants in Jombang is very high.
Antirazzismo cattolico e questione nera nel secondo dopoguerra
Authors: Caponi Matteo
Published: April 2022

L'articolo indaga come una crescente attenzione alla questione nera abbia fatto da cornice all'ascesa di una sensibilità antirazzista nel cattolicesimo italiano del secondo dopoguerra.L'analisi mette in discussione il cliché di un innato antirazzismo cattolico, esaminando l'interrazzialismo come modello dominante: una terza via che si opponeva sia al razzismo sia all'antirazzismo militante, umanitario ed egualitario. La nozione di antirazzismo faticò a essere recepita dalla cultura cattolica di massa fino agli anni Sessanta. La svolta dipese dall'impatto di tre fenomeni di risonanza mondiale: la decolonizzazione, l'apartheid in Sudafrica e il movimento per i diritti civili negli Stati Uniti. Ironia della sorte, la psicosi anticomunista della Guerra fredda costituì un motore dell'antirazzismo cattolico: occorreva scongiurare che il "risveglio" dei popoli neri avvenisse sotto l'influenza sovietica. Il pontificato di Giovanni XXIII, l'aggiornamento conciliare e la crisi del 1968 posero le basi per un cambio di paradigma; gli orientamenti antirazzisti si intrecciarono a significati progressisti e utopie rivoluzionarie controculturali.
Un antirazzismo mancato? Classe e razza nel dibattito di area comunista su bambini meridionali e classi differenziali negli anni Settanta
Authors: De Michele Grazia
Published: April 2022

Uno degli elementi caratterizzanti le migrazioni interne verso le città del triangolo industriale negli anni Cinquanta e Sessanta del Novecento è stato il razzismo antimeridionale. Nelle scuole elementari molti tra i figli dei nuovi arrivati vennero immessi nelle cosiddette classi differenziali anche grazie al supporto scientifico offerto da psichiatri, psicologi e assistenti sociali che, nello stesso periodo, definirono i bambini di origine meridionale come disadattati, in ragione di una supposta incapacità di adattarsi a un ambiente più progredito. Negli anni Settanta, il fenomeno venne sottoposto ad aspre critiche, ma il razzismo che l'aveva alimentato non fu riconosciuto come tale. L'articolo analizza i limiti del dibattito sviluppatosi tra educatori e intellettuali di area comunista, che lessero la discriminazione nei confronti degli alunni meridionali esclusivamente in termini di classe sociale secondo i dettami di un marxismo tipicamente eurocentrico. 
Il movimento antirazzista in Italia e le politiche migratorie, 1989-2002
Authors: Colucci Michele
Published: April 2022

Il contributo ricostruisce l'evoluzione storica del movimento antirazzista in Italia, concentrandosi sul tema delle politiche migratorie. L'antirazzismo si diffonde in parallelo allo sviluppo dell'immigrazione straniera, che in Italia avviene in modo intenso dopo il 1989. Matura allora un dibattito nazionale sulle politiche migratorie: il movimento antirazzista contribuisce all'orientamento di tale dibattito e alle scelte legislative conseguenti.Nell'articolo vengono esaminate le principali fasi storiche comprese tra il 1989 e il 2002. Durante questo periodo il movimento antirazzista si confronta con l'emergere di pulsioni razziste, con l'inserimento sempre più diffuso dell'immigrazione nel mondo del lavoro, con la crescita quantitativa dell'immigrazione straniera, con la politicizzazione sempre più evidente del tema migratorio.Si tratta di un periodo in cui in Italia avvengono profonde trasformazioni sociali e politiche: la storia del movimento antirazzista può aiutare a comprenderle e contestualizzarle.
La pratica della cittadinanza "dal basso" nelle associazioni di donne migranti
Authors: Cherubini Daniela
Published: April 2022

L'articolo analizza le forme di esercizio e rivendicazione della cittadinanza dal basso, portate avanti da diverse associazioni di donne migranti attive nel sud della Spagna (Andalusia), indagate attraverso una ricerca etnografica. L'analisi mostra come le attiviste coinvolte nella ricerca agiscono nella sfera pubblica sulla base di un'identità complessa, nella quale l'appartenenza di genere e la condizione migrante si intrecciano con l'appartenenza etno-culturale e di classe. Da tale posizione, avanzano una fondamentale richiesta di inclusione, ma anche un'opera di ridefinizione della cittadinanza in senso inclusivo. Mettono in discussione il confine tra cittadini/e e non cittadini/e, e risignificano la cittadinanza come una questione di accesso a diritti e risorse, di riconoscimento e di parità partecipativa. Il caso studio vuole contribuire, in ottica intersezionale, alla comprensione delle forme di cittadinanza dal basso elaborate da settori diversificati della popolazione migrante, e delle trasformazioni della cittadinanza ad esse collegate.
The public discourse on immigration in Italian school textbooks
Authors: Valente Adriana , Tudisca Valentina , Caravita Silvia
Published: April 2022

The authors present an analysis of the History and Geography textbooks that were the most used in Italian secondary schools in the school year 2016-2017, aimed at investigating immigrant representation and migrations through images and texts. Indeed, textbooks are a kind of media that can impact on the public discourse while presenting a certain vision of society to those that are becoming the future citizens, conveying - explicitly and implicitly - value systems. In this sense, they can act as tools to build support for power or cultural resistance, an aspect that is reflected in the so called "Didactic Transposition Delay", which helps to understand the relationship between knowledge and values. Given their "political" nature, albeit cloaked in an institutional authority, it is important to reflect on this type of media in a critical manner, particularly with respect to the promotion of discrimination and stereotypes. Among the findings of the study, a narrative predominantly describing migrants as "victims" and as a resource (especially eco-nomic) for the country of destination, albeit not lacking representation in terms of problems, while barely making room for the subject of human rights. At the same time, the images convey a representation that is predominantly "male", tending to "veil" the presence of women, contrary to the data, but with certain elements which the authors consider as developments with respect to previous studies.
Henry More against the Lurianic Kabbalah. The Arguments in the Fundamenta
Authors: Di Biase Giuliana
Published: April 2022

The Cambridge Platonist Henry More was fiercely averse to the Lurianic Kabbalah, with which he became acquainted through the two tomes of the Kabbala denudata (1677; 1684). More contributed to the first tome substantially and was highly influential in shaping the reception of this work, edited by Christian Knorr von Rosenroth. He denounced the incompatibility of the Christian religion with Luria's system and in his last contribution, the Fundamenta, he put forward an apagogical argument meant to show the inconsistency of Luria's teaching. The article aims at exploring the nature of More's argument so as to highlight the philosophical essence of his criticism, the intention of which was to emphasize the incompatibility of the Kabbalah with any form of rational speculation. Luria's doctrine appeared to More to be a compromise between materialism and spiritualism, a sort of hybrid theory that was even worse than materialism, given its misleading theistic appearance as well as the lack of internal coherence. This compromise was also morally unacceptable, being symptomatic of weakness of the will.
Beyond the Boundaries of Representational Thinking: Hegel's interpretation of Jakob Böhme during the Jena Period
Authors: Farinella Simone
Published: April 2022

The aim of this article is to investigate Hegel's reception of Jakob Böhme during the Jena period. In section 1, the Author analyses Fragment 46 and Fragment 49 of The Jena Wastebook, in which Hegel outlines a God's life-course inspired by Böhmian motives. For Hegel, the Böhmian theory of the wrath of God and fall of Lucifer expresses the opposition and reconciliation between nature (Lucifer) and spirit (God). The relational model here developed is that of an external negativity, which annihilates nature's being-for-itself. In section 2, the Author shows Hegel's use of the same relational model in The Jena Logic and Metaphysics, assuming a Kantian and Böhmian terminology. The part on the Highest Essence explains the opposition between the good and evil principles and their necessary unity. The introjection of the evil principle into the good principle is exactly what leads Hegel to investigate philosophically the myth of the fall. In sections 3 and 4, the emphasis is on the connection of this myth with the ideas of the wrath of God and fall of Lucifer: The Jena Logic and Metaphysics and The Phenomenology of Spirit consider Böhme's thought as a prefiguration of that self-relational negativity which discloses the development of the thing itself.
Social Ageing: Fragments of an Autoanalysis
Authors: Fowler Bridget
Published: April 2022

This essay originally interprets self-objectivation as utterly exceptional liberty (and privilege) of sociological observers. The author touches upon several dimensions of her social identity. Starting with the process of downward mobility undergone by her family, she goes over private issues such as her loss of faith and marital dynamics (as well as political engagement and relationship with academic institutions), linking her existential course to certain broader topics in particular: e´migre´s' condition, split habitus, female subjugation, symbolic violence, interdisciplinarity.
Akta Perdamaian oleh Notaris dalam Penanganan Tindak Pidana berdasarkan Keadilan Restoratif
Authors: Agussari Rosnia , Gozali Djoni S , Faishal Achmad
Published: April 2022

Penyelesaian perkara pidana berdasarkan keadilan restoratif pada dasarnya di selesaikan di kantor polisi dengan mengedepankan perdamaian antara pihak pelaku pidana dan pihak korban. Apabila tercapai suatu perdamaian maka hukum pidana terhenti, melainkan di lanjutkan dengan hukum perdata yang berkaitan dengan perjanjian perdamaian. Perjanjian perdamaian di kantor polisi berupa bentuk tanggung jawab pelaku pidana seperti mengembalikan barang, mengganti kerugian, menggantikan biaya yang ditimbulkan dari akibat Tindak Pidana serta mengganti kerusakan yang ditimbulkan akibat Tindak Pidana dengan dibuktikan dengan surat kesepakatan perdamaian oleh petugas kepolisian. Adapun upaya para pihak dalam mencari keadilan serta perlindungan hak dan kewajiban apabila terjadi wanprestasi terhadap perjanjian perdamaian tersebut, para pihak dapat meminta notaris untuk membuat akta perdamaian dan akta tambahan lainnya yang dianggap melindungi pihak korban untuk memperoleh haknya kembali. Penelitian ini merupakan penelitian hukum normatif yang bersifat preskriptif analitis. Pendekatan yang digunakan adalah pendekatan perundang-undangan dan pendekatan konseptual. Penelitian ini akan membahas mengenai kedudukan akta perdamaian serta kewenangan notaris dalam penanganan perkara pidana berdasarkan keadilan restoratif demi mencapai keadilan dan perlindungan hukum bagi para pihak yang membuat perjanjian perdamaian.
ReFocus: The Films of Paul Schrader
Authors: Siegler Elijah
Published: April 2022

This is a book review of Michelle E. Moore and Brian Brems, editors, ReFocus: The Films of Paul Schrader (Edinburgh University Press: 2020).
Bollywood Horrors: Religion, Violence and Cinematic Fears in India
Authors: Meheli Sen
Published: April 2022

This is a book review of Ellen Goldberg, Aditi Sen, and Brian Collins, eds., Bollywood Horrors: Religion, Violence and Cinematic Fears in India (Bloomsbury Academic, 2021).