bluuebunny/crossref_metadata_2025 huggingface dataset:
Financial Management experiences of township early childhood development centre principals in Gauteng Province of South Africa
Authors: Aina Adebunmi Yetunde
Published: February 2023

The delivery of high-quality education is considerably aided by effective school management, which includes managing finances. Understanding financial management in early childhood education (ECE) is crucial and essential given that high-quality ECE is now recognised as a foundation for successful higher education and productive adulthood. This study aimed at exploring township early childhood development centre principals' experiences with their financial management responsibilities. Four early childhood development centres were purposively selected from the township areas in Gauteng Province, South Africa, using a qualitative research approach and case study design. Data was collected through in-depth semi-structured interviews with the principals of the selected centres. The findings demonstrate that the ECD principals have limited knowledge of financial management responsibilities and that there is no formal legal framework for financial management at ECD centres. Township ECD financial management practices include planning (identifying needs), organising (fees paid into the bank account and procurement made through bank card) and reporting (giving accounts to the board of directors and parents). In this study, it can be concluded that township ECD principals are making an effort to ensure effective financial management of their centres. However, several obstacles, including the principals' lack of accounting expertise, their heavy workload, the non-payment of school fees, and the absence of a financial management legislative framework, prevent ECD centres' effective and efficient financial management.
Ring polymer translocation through nanopore in a crowded environment
Authors: Negash Solomon , Umeta Deme Tesfaye , Kenea Dereje , Gashu Chimdessa
Published: February 2023

In this paper, we use a Monte Carlo (MC) simulation method in two dimensions with a bond fluctuation model (BFM) to investigate the translocation of a ring polymer through a nanopore in a crowded environment . We put the two middle monomers in the center of the pore, to con-
quer the entropic obstruction caused by the presence of an mpenetrable membrane wall. In our system, a fixed size and same density of crowding agents (φ ) are populated orderly
on the left (cis) side and randomly on the right (trans) side of the wall. As the translocation of macromolecules is an important process to study the properties of polymers, we explored the static property of the polymer which is characterized by a radius of gyration and the dynamic properties, characterized by mean square displacement and escape time. We found that the scaling exponents of the average square of radius of gyration as a function of size of the polymer N varies with density of the obstacle beads, φ . Our current investigation appears that the universal power-law relation of escape time τ as a function of polymer size (τ ∼ N 2.50 ) is
influenced by the density of the crowding agents. Furthermore, our research shows that the size of the polymer, the size of the pore, and the density of the obstacles all have a
significant impact on polymer diffusion.
The Association of Burnout Syndrome and Suicide Ideation between Gynecology and Emergency Room Medical Professionals: A Cross Sectional Study
Authors: Khurshid Saba , Naveed Zunaira , Shafique Nadia
Published: February 2023

Background
Burnout syndrome and suicide behavior among doctors are a global concern. Work gives workers a sense of social cohesion, belonging, and future stability; yet hectic hours, pressure, and stress increase their distress. Therefore, the current study aimed to investigate burnout syndrome and suicidal ideation in gynecological and emergency departments.
Method
A purposive sample of 300 medical professionals working in gynecology and emergency departments at tertiary care hospitals was recruited. The demographic Sheet, the Maslach Burnout Inventory, and the Suicidal Ideation Attributes Scale (SIDAS) were applied to assess burnout and suicide risk assessment.
Findings:
Of the overall sample, 188 (62.7%) came from the emergency and 112 (37.3%) from gynecology. Medical professionals have shown a robust connection between burnout syndrome and suicidal ideation. The findings revealed that occupational exhaustion (β = .17, p < .001), depersonalization (β = .27, p < .001) and personal accomplishment (β = .16, p < .001) positively predicted suicidal ideation among medical professionals working in emergency and gynecology department. Burnout syndrome subscales significantly associated and different in term of demographic variables such as gender department, professions, family structure, working hour and experience with reference to chi square (p < 0.001). Working experience in emergency department, working hour per day and working experience could be predictor of occupational burnout syndrome.
Conclusion
The results of the current study strongly support taking preventive action. The medical health departments of Pakistan must properly explore this matter and take into account a medical staff evaluation of mental health. With this strategy, we can lessen the risk of suicide by providing quick support to medical professionals.
Resolution of barriers to Green Human Resources Management through its drivers in the textile sector of an emerging economy
Authors: Miao Miao , Zaman Syed Imran , Khan Sharfuddin Ahmed , Jiang Wan
Published: February 2023

Green HRM is vital in organizations' sustainability policies, seen as a recent research trend. This paper aims to identify the five most important drivers and critical barriers to Green HRM implementation in Pakistan's textile industry. Data were collected from a group of Pakistan's textile industry experts, and the Fuzzy Delphi and Fuzzy AHP methods were used to examine the results. The findings reveal that the most critical five drivers of Green HRM implementation are improvement in company image, maximum use of resources, reduced waste, stimulation of growth and innovation, top management support, and work-life balance. The results further explore the five critical barriers: difficulty and complexity in green technology adoption, lack of organizational support, employee resistance, and lack of culture and knowledge of individuals. This analysis is valuable to researchers by highlighting research gaps and making specific suggestions on Green HRM research. This study proposes a detailed research structure for future studies, particularly implementation recommendations for Green HRM practices. Organizations should adequately evaluate the green culture and work-life balance of employees. They can also support and engage employees in a green environment and manage organizational sustainability performance. Using different methods, this research may also be carried out in the future, especially comparing the various drivers and barriers of Green HRM of small and large companies in Pakistan. In this research, new barriers and drivers are used in this context. The paper takes a detailed look at analyzing drivers and barriers of Green HRM implementation in an organization through DELPHI and MCDM techniques. This research paper acknowledges that Green HRM implementation's most crucial aspects are the organization's barriers and drivers. An organization applies the DELPHI technique to validate known barriers and drivers of Green HRM execution. This research aims to develop the source of information within the literature on drivers and barriers of Green human resource management execution in an organization and the collection of organizational sustainability performance.
Novel -nutrient sources improves nutrient content, uptake and NUE of wheat (Triticum aestivum L.)
Authors: singh Bal veer
Published: February 2023

The authors have requested that this preprint be removed from Research Square.
Composition of Mangroves and Mangrove Associates in Barangay Ata Atahon, Nasipit, Agusan del Norte, Philippines
Authors: Cabuga Jr. Cresencio C. , Lopez Aldrin B , Cuarteron Neprissa E , Pangapalan Nñeka Jean A.
Published: February 2023

Mangroves are essential components of the coastal biome and have an extremely productive ecosystem. It provides benefits for both the environment and humans. Valuation of the diversity and species composition plays a crucial role in the conservation and protection. This study aimed to assess the composition of mangroves and mangrove associates in Barangay Ata-Atahon, Nasipit, Agusan del Norte, Philippines. Three sampling stations were established with a 50-meter interval in every station. Transect lines of 50 meters were laid perpendicular to the shoreline. The results show that 19 species of mangroves and 5 mangrove associates were recorded. Ceriops decandra was found to be the dominant species with 303 individuals and constituting 36% of the entire mangroves population. While Camptostemon philippinensis, Rhizophora apiculata, Rhizophora mucronata had the lowest number of individuals and made up a combination of 5%. In mangrove associates, Avicennia rumphiana made up 47% of the population and was followed by Avicennia marina (40%). This implied that the study area is less diverse based on the observed species when compared to the 46-mangrove species found in the Philippines alone. Necessarily, reforestation and conservation efforts must be attained to fill the gaps between the community and mangrove sustainability. Thus, determining the species diversity and composition measures ecological status. Mitigations and ecological management must be enacted by the locality to further conserve the mangrove ecosystem.
Nature-based solutions for flood–drought mitigation using a composite framework: a case-based approach
Authors: Agarwal Divya S. , Bharat Alka
Published: February 2023

Water-related hazards like floods and droughts are increasing due to climate change. The study aims towards balancing a double edge situation of the inevitable flood and drought. The Soil Conservation Service-Curve Number (SCS-CN) method is used to calculate the rainfall–runoff and the Topographic Wetness Index (TWI) is used for identifying potential water accumulation zones, whereas the Normalized Differential Water Index (NDWI) is used to calculate surface waterbody variations and the Soil Water Index (SWI) is used to identify zones varying in the range of dry-to-wet soil moisture. The study focuses on the use of nature-based solutions (NbS) for achieving mutual flood–drought mitigation for the pilot case of the Banaskantha district, Gujarat, and is validated for the study case of the Muzaffarpur district, Bihar. The application of the developed contingency plan in the form of an applicability rubric agrees to solve the issue by 44.44% for the pilot case and 22.22% for the study case. It suggests the application of NbS for the regions having similar situations of flood–drought as of the pilot case.
Odnowa teologii szansą dla Kościoła i wiary. Projekt Josepha Ratzingera/Benedykta XVI
Authors: Babiński Jarosław , Kuczyńska Marzena
Published: February 2023

Obecnie wiele się mówi o kryzysie Kościoła i jednocześnie wskazuje drogi jego naprawy. Problem jest na pewno złożony. Wiele czynników ma bowiem wpływ na kondycję wiary i Kościoła. Benedykt XVI wskazuje jako na jeden z wielu – konieczność odnowy teologii. Postuluje intensywny wysiłek obrony jej naukowej autonomiczności, doceniając wartość dialogu z innymi dziedzinami wiedzy, zwłaszcza filozofią. Przypomina także o zadaniach teologii w Kościele i świecie. Podkreśla zwłaszcza jej eklezjalność, chrystocentryczność oraz obowiązek nieustannej obrony prawdy.
Fernando Fueyo Laneri y el fin de la “escuela clásica” del derecho civil chileno
Authors: Alcalde Fernando
Published: February 2023

El presente trabajo expone la vida de Fernando Fueyo Laneri mirado como un jurista. Comienza con un esbozo biográfico que permite situar el tiempo durante el cual vivió y los principales hitos de su historia personal, así como la función de cierre que le corresponde respecto de lo que cabría denominar la “escuela clásica” del derecho civil chileno. Después se explica la contribución que supuso su trabajo académico, separando sus publicaciones, el plan que previó para la renovación de la disciplina dogmática que cultivaba y sus intentos por impulsar una recodificación del derecho nacional. Sin embargo, la influencia de este autor no se agota con su muerte ocurrida en 1992, pues sus anhelos se han prolongado a través de la fundación que lleva su nombre y que fue constituida por su familia y la Facultad de Derecho de la Universidad Diego Portales.
Expression and Predictive Significance of FHL1 and SLIT3 in Surgically
Resected Lung Adenocarcinoma
Authors: Song Jinjing , Liang Kai , Wei Tongtong , Li Li , Huang Zhiguang , Chen Gang , Mao Naiquan , Yang Jie
Published: February 2023

Objective:

Lung adenocarcinoma (LUAD) is the most common type of lung cancer.
However, predictive biomarkers for early efficacy and prognosis evaluation in patients with surgically
resected LUAD are not completely explained.

Methods:

Differentially expressed genes (DEGs), gene ontology (GO) and Kyoto Encyclopedia of
Genes and Genomes (KEGG) were identified by RNA sequencing (RNA-Seq) between thirteen
LUAD tissues and five normal lung tissues. The expression of DEGs was confirmed by qRT-PCR
and a validated cohort from GEPIA. Protein-protein interaction (PPI) network of the top 5% DEGs
was constructed by STRING and visualized in Cytoscape. Immunofluorescence results were acquired
from clinical specimens from LUAD patients. The expression of FHL1 was analyzed by
ImageJ. Survival analysis was performed using the GEPIA dataset.

Results:

Consistent with the RNA-Seq data, validation of DEGs expression by qRT-PCR and GEPIA
cohort showed that FHL1 and SLIT3 were down-regulated in LUAD patient tissues compared
with non-tumor tissues. Moreover, FHL1 was significantly reduced in LUAD cell lines compared
to the bronchial epithelium cell line (P <0.01). However, SLIT3 was elevated in A549 and H1299
cells (wide type EGFR) (P < 0.05) while decreased in HCC827 and PC9 cells (mutant EGFR)
compared to BESA-2B cells (P < 0.01). PPI network revealed the most significant cluster with 10
nodes and 43 edges. Immunofluorescent staining also showed that the expression of FHL1 was
lower in LUAD tissues compared with that in normal lung tissues (P < 0.01). The expressions of
SLIT3 and FHL1 were positively correlated. Specifically, the higher expression level of SLIT3 and
FHL1 independently predicted a better prognosis (P < 0.01 or P < 0.05).

Conclusion:

Our findings provide two novel candidates, FHL1 and SLIT3, for prognostic evaluation
and treatments after surgery.
A randomised comparative clinical study to assess the efficacy of Arjuna Twak Churna Lepa and Yastimadhu Churna Lepa along with Khadira Churna in the management of Vyanga with special reference to Melasma
Authors: Kamala Hunasagi  , Uma Patil
Published: February 2023

Background:  Vyanga is one of the skin disease and it is included under the heading of a Kshudra Rogas. Vyanga is pathological condition of the facial skin which is produced by the vitiation of the Vata, Pitta Doshas and Rakta Dhatu and Manasika Nidanas such as Bhaya, Krodha and Shoka are the main culprits characterized by the presence of Niruja, Tanu, and Shyava Mandalas over the face. Vyanga is correlated with facial Melasma, melasma is skin condition in which a hyperpigmented patches over the face of the individual showing the similarities in clinical features. Objectives: To assess the efficacy of Arjuna Twak Churna Lepa and Yastimadhu Churna Lepa along with Khadira Churna in the management of Vyanga with special reference to melasma. Methodology:  A comparative clinical study was conducted on Vyanga Roga for the period of 21 days. The patients were divided into 2 groups. In Group A 20 patients were administered with Arjuna Twak Churna Lepa along with Khadira Sara Churna and in Group  B  20  patients  were  administered  with Yasthimadhu Churna Lepa along with Khadira Sara Churna. Results: Group A and Group B have shown statistically significant result. Group A treated with Arjuna Twak Churna Lepa along with Khadira Sara Churna shown better result compared with Group B treated with Yasthimadhu Churna Lepa along with Khadira Sara Churna.
Comparative pharmaceutical and analytical study of Kasisadi Ghrita prepared by two different methods
Authors: Padmanabha Lal R  , Govinda Sharma K  , Gazala Hussain  , Asha Vithal Bhat  , Ramya M Pavate  , Deekshitha S
Published: February 2023

Introduction: Sneha Kalpana are the dosage forms which can be used both internally as well as externally. Generally, Sneha Kalpana is prepared by using Agni as source of heating. However, Kasisadi Ghrita is an exception where the sunlight is used as source of heating. This unusual method of preparation looks attractive because of natural heat (sunlight) that is required in the preparation and the yield that may be obtained. The Sneha is heated with volatile drugs in Surya Paka for a specific time so that less heat allows them to leave their active principles in Sneha. The difference between Bhanupaka and Agnipaka is also an area of interest, on this formulation as far as its manufacturing is considered. Kasisadi Ghrita is a herbo-mineral formulation indicated for various skin diseases. Materials and Methods: Kasisadi Ghrita were prepared by classical method of Bhanupaka (KGB) and usual method of Agnipaka (KGA). Both KGB and KGA were analyzed as per the standard protocol. Discussion and Conclusion: Preparation of Kasisadi Ghrita by Agnipaka method is easy as it consumes less time. There were no pharmaceutical constraints in preparation of both samples. Tamra Paatra helps to retain more heat than other vessels during Bhanupaka. The results of the pharmaceutical and analytical study can be considered as the preliminary standards for the preparation of Kasisadi Ghrita.
Clinical trial to evaluate the efficacy of Sandhaniya Cast in Ankle Sprain
Authors: K Nikhil Kaushik  , KM Sweta  , Dhyan Surendranath
Published: February 2023

Ankle is the most common site for acute musculoskeletal injuries and sprains. Acute ankle trauma is responsible for 10-30% of sports related injuries in young athletes. Ankle sprain is characterized by pain, swelling with or without deformity. According to the Modern science the treatment modalities adopted for the ankle sprain are ankle brace, below knee cast and ankle strap. Inadequate treatment of ankle sprain can lead to chronic problems such as decreased range of motion, pain and joint instability. Acharya Sushruta advocates Alepa with Asthisandhaniya Dravyas for the management of Bhagna. These dravyas when used in the form of Lepa have the properties of Sandhaniya, Shophahara and Vedanasthapaka action. It is a need of hour to bring up new innovative, readily available, patient friendly and time saving techniques which possess the same effect. Hence this study is taken up to bring the Manjistadi Lepa in the modified form as Sandhaniya cast. Such kind of medicated casts weren’t in use till date which makes it unique. This would not only help in immobilization like any other ankle brace or ankle binder, but also reduces localized edema and pain due to its Vedanasthapaka and Shophahara properties and also accelerates the healing.
An observational study to explore the Samprapti Ghatakas in Hypothyroidism
Authors: Ashwini PK  , Geetha B Markande  , Prashanth Jain
Published: February 2023

Background: Hypothyroidism is the most common functional disorder of the thyroid gland. It is a hypometabolic clinical state resulting from inadequate production of thyroid hormones for prolonged periods. The prevalence of this disease in India is 6% and more than 10 million cases per year are reported. It is a multisystemic disorder which has a wide range of clinical symptoms. This condition is not mentioned in Ayurveda classics by any specified name. In Ayurveda, determining the elements that contribute to Samprapti is essential in developing a treatment plan. Hence, the current study attempts to evaluate the Samprapti Ghatakas and as a result, formulate probable Samprapti. Objectives: To study and explore the Samprapti Ghatakas of hypothyroidism and to propose possible Samprapti. Methods: The study was conducted in 100 cases of hypothyroidism between the age of 16 to 70 years. A case proforma was prepared which includes history taking, physical signs and symptoms and required examination. The calculations were done in Microsoft excel and the values obtained were assessed on the basis of percentage of individual parameters in relation with Samprapti Ghatakas of hypothyroidism. Results: Kapha and Vata are the main Doshas involved in the Samprapti. Important Dooshyas are Rasa, Meda. Agni involved is Dhatwagni and the disease is caused primarily due to Dhatwagnimandya. Udakavaha, Annavaha, Medovaha, Swedavaha, Purishavaha, Rasavaha are the main Srotas involved with Sanga type of Srotodushti. Udbhava Sthana can be considered as Amashaya; Sanchara Sthana, Vyakta Sthana and Adhishtana is Sarva Shareera. All the three Rogamarga are involved.
A randomized open label control clinical study to evaluate the efficacy of Kshoudra as Dahanopakarana for the pain management in Snayuvikara with special reference to Achilles Tendinitis
Authors: Anju DR  , N Muralidhara  , KM Sweta  , Dhyan Surendranath
Published: February 2023

Achilles Tendinitis is otherwise called as Achilles Tendinopathy which causes pain and stiffness, swelling, thickening and weakness of achilles tendon, which worsens with activity, commonly seen in sports person. As per Ayurvedic parameters this condition can be correlated to Snayugata Vikara, which usually presents with Sthambha, Shula, Kriyavasakthi. Treatment include Snehana, Upanaha, Agnikarma, Bandhana and Mardana. In the contemporary science the treatment modalities available are RICE technique, hydrocortisone injection, radiant heat or diathermy, release of plantar fascia from tuberosity of calcaneus through surgery. In Susrutha Samhitha Agnikarma Chikitsa is explained for the par excellence for these conditions considering its Vatakapha Shamaka, Amapachaka property and also this is easy to perform. Agnikarma with the help of Panchadhathu Shalaka was already established with 65% of success rate in the management of Achilles tendinitis. The therapeutic effects of Agnikarma with Kshoudra includes relief of pain and muscle spasm, acceleration of healing, promotion of resolution of inflammation and increase in the range of movement of joint. This study is done by considering Vatakapha Shamaka, Amapachaka, Yogavahi properties of Kshoudra and also this was easy to perform with better cosmetic value. Hence the stagnation of current knowledge demanded an effective method to tackle the painful heel condition.
A clinical study to evaluate the effect of Lekhana Vasti in the management of Sthaulya
Authors: Kanduri Ramanuja Acharyulu  , Padmakiran C.  , Sandesh Shetty
Published: February 2023

Sthaulya is one of the Santarpanotta Vyadhi. It is considered as one among the Ashta Ninditeeya Purusha. It is a Rasa Nimittija and Medo Pradoshaja Vyadhi Avyayama, Athiasana, Athishayana and so on are some of the Nidanas of Sthaulya. Most of the world’s population live in countries where overweight and obesity kills more people than underweight. Apatarpana Chikitsa is main line of treatment in Sthaulya. When there is involvement of Kapha Medas and pathogenesis of Avarana, the condition needs Teekshna Basti with Lekhana properties. The Varanadi Gana Kwatha which is having similar action is selected as Kalka and Kwatha Dravya in the present study. To increase the Teekshnata, the Amla Kanji as Avapa Dravya has been selected. Objectives - Hence, the following study was taken to evaluate the effect of Lekhana Basti in management of Sthaulya. Methodology - 20 patients were taken in the study and were administered. Varanadi Lekhana Basti in Kala Basti format. Matra Basti with Murchita Tila Taila was given. Patients were assessed for weight BMI, biomarkers, bodily circumferences before and after treatment and after follow up.
An open label single arm prospective clinical study on the combined effectiveness of Panchanimbakam Churna Vati and Pathyadi Lepa in Kitibha Kushta (Psoriasis)
Authors: Kalpana Bhamini  , Lakshmiprasad L. Jadhav  , Rajouri Joshi
Published: February 2023

Kitibha Kushta is mentioned under Kshudra Kushta and is one among the Ashtamahagada. There is the involvement of Tridosha in all Kushta but the predominance of Dosha makes the types & manifestations of Kushta different. Psoriasis is one of the most common skin disorders. It is a papulosquamous disorder of the skin characterized by sharply defined erythematosquamous lesions. It is chronic and is well known for its course of remission and exacerbation. Prevalence of psoriasis in adults varies from 0.44 to 2.8%, with a much lower prevalence in children. The combined formulations Panchanimbakam Churna Vati and Pathyadi Lepa, mentioned in Gadanigraha and Yogaratnakara respectively, are indicated for the management of Kitibha Kushta. The combination collectively contains Kushtaghna Dravyas and has Katu, Tikta and Kashaya Rasa, Laghu, Ruksha Guna, and Ushna Veerya that are helpful in Samprapti Vighatana of Vata and Kapha dominant Kushta. Material and Methods: Among 30 registered participants, 25 completed the treatment. They were administered with Panchanimbakam Churna Vati orally 3 gm per day before food and Pathyadi Lepa externally for 30 days. The Lakshanas and PASI score was assessed on the 1st, 15th, and 30th. For Statistical analysis, subjective parameters were assessed by Cochran’s Q test followed by McNemar test, and objective parameters were assessed by Repeated Measures Anova and Paired T-Test. Results: There was a statistically significant improvement in the signs and symptoms of Kitibha Kushta (Psoriasis)(p<0.05). Conclusion: The combination of Panchanimbakam Churna Vati and Pathyadi Lepa, is effective in the management of Kitibha Kushta (Psoriasis)
A randomized controlled comparative clinical trial on Jwarahara effect of Mukkaamukkatukaadi Syrup with Kiratatikta Syrup in Febrile Children
Authors: Suja K  , Prathviraj Puranik  , Sharashchandra R  , Sandesh Kumar Shetty
Published: February 2023

Ayurvedic classics have described many diseases amongst which Jwara stands first because of its uniqueness to make everyone suffer, since birth to death. Jwara being one of the commonest symptoms which accompanies almost all constitutional diseases has been coined with the term Rogadhipathi. Fever is defined as temperature in rectum more than 100.4°F (38°C), in oral cavity above 99.5°F (37.5°C) or in axilla above 99°F (37. 2°C). If we don’t treat fever in its earlier stage, there will be more chances of hyperpyrexia which may cause febrile convulsions which leads to brain damage. Therefore, it is necessary to control fever at its earlier stage. One such Jwarahara formulation is Mukkaamukkatukaadi Gulika and Kiratatikta which is converted into syrup form to overcome the palatability issues. A sample size of 30 patients was selected by simple random sampling method and 15 patients were allotted in two groups. It was planned to compare the result between Mukkaamukkatukaadi syrup in Group A study group for STG and LTG and Kiratatikta syrup in Group B control group for STG and LTG. On STG comparison, the difference in mean in Group A and Group B were 0.49,0.44 before treatment changed to 0.96 and 0.98 after treatment respectively.  On LTG comparison, the difference in mean in Group A and Group B were 0.49, 0.44 before treatment changed to 2.02 and 1.96 after follow up respectively. This depicts both the formulations effective when consumed for longer duration. From the results and observations it can be concluded that Group A and Group B are equally effective and equally significant on reducing the temperature in both STG and LTG. No adverse drug reaction was found during the study.
Pharmacognostical evaluation of Rajakoshataki (Luffa acutangula (L.) Roxb.
Authors: Anju Balakrishnan  , Mohammed Faisal  , Suchitra Prabhu
Published: February 2023

Introduction: Rajakoshataki (Luffa acutangula(L.) Roxb. is a succulent trailing climber that belongs to cucurbitaceae family. The present study attempts to evaluate macroscopy, microscopy, physio-chemical, phytochemical and HPTLC studies of different extracts of fruit of Luffa acutangular (L.)Roxb. Materials and Methods: Fresh Rajakoshataki fruit was collected from the local vegetable market, Udupi. Sample was preserved in fixative solution. The fixative used was FAA (Formalin-5ml + Acetic acid-5ml + 70% Ethyl alcohol-90ml) for pharmacognostical study. Left sample were shade dried for preliminary phytochemical test, physiochemical and HPTLC. Results and discussion: Microscopic image showed the presence of normal fruit structure like Epicarp, Mesocarp and Endocarp. The study proved the presence of Alkaloids, Tannins, Saponins and carboxylic acid and HPTLC densitometric graph showed the peaks. Conclusion: These parameters help in the identification and standardization of fruit of Rajakoshataki.
Comparative clinical study to evaluate the efficacy of Vartaku Gutika and Chitrakadi Vati in the management of Grahani Roga (Irritable Bowel Syndrome)
Authors: Chande Aarti , Acharya Shripathi Acharya G. , Rao Madhavi
Published: February 2023

Background: Grahani is a disease of great clinical relevance in modern era because of it’s directly link with improper food habits and stressful lifestyle. Agnimandhya is root cause of Amadosha and it is crucial factor for Grahani and causes Pakwa Apakwa Mala Pravritti. It can be correlated to irritable bowel syndrome. About 15% of the general populations have symptoms that justify diagnosis of IBS. As in the Grahani Agnimandhya is important factor in Samprapti, so it should be treated with Agnivardhan Yogas. Vartaku Gutika which is described in Chakradatta as reseach drug and Chitrakadi Vati mentioned in Charak Samhita for control group. Objectives: To evaluate the effect of Vartaku Gutika and to compare the effect Vartaku Gutika and Chitrakadi Vati in the management of Grahani. Methods: 40 enrolled subjects completed the course of intervention. Randomly they were divided into two groups, group A was given Chitrakadi Vati and group B Vartaku Gutika abd they were adviced 500 mg of tablet two times after food with Ushna Jala, and were adviced to follow Pathya Aahara. Statistical analysis with paired t test, Wilcoxon signed rank test, Mann Whitney test, Mc Nemar test and Chi square test was performed for numerical, ordinal and nominal data respectively. Results: Statistically significant reduction of Lakshana of Grahani in both the group was observed. Overall Vartaku Gutika has more improvement in compared to Chitrakadi Vati. Conclusion: Both Vartaku Gutika and Chitrakadi Vati breaking the pathology of Grahani, but in this study Vartaku Gutika is more effective than compared to Chitrakadi Vati.
A randomized comparative clinical study of Manjistha Ghrita (Rubia Cordifolia Linn.) and Go-Ghrita in the management of Kikkisa (Striae Gravidarum)
Authors: Spoorthi G Hegde  , Jalindar Dhamale
Published: February 2023

Skin ailments are the third most common disease     in developing countries and in modern society it is a subject of sociomedical importance. One such ailment associated with pregnancy is Kikkisa (Striae gravidarum). Kikkisa (Striae gravidarum) is a Garbhini Vyadhi which occurs mostly in Sapta Masa of Garbhini Kala (7th month of pregnancy). It is a condition where growing foetus enlarges Garbhashaya which displaces Doshas Vata, Pitta and Kapha upwards, reaches Uras and produces Daha causing Kandu on abdomen, breasts and thighs. Striae gravidarum are seen in 50-90% of pregnant women due to many physiological, metabolic and hormonal changes along with increased stress on connective tissue will lead to breakage of fibers. Manjistha (Rubia cordifolia Linn.) is considered as Raktashodaka and Kushtanuta. Considering the risk factors in pregnancy the current study has been taken up under external application of Manjistha in the form of Ghrita over internal usage of Kwatha as mentioned in authentic text. Keeping this in mind a comparative study was conducted to analyze the effect of Manjistha Ghrita and Go-Ghrita on Striae gravidarum.30 subjects after considering the inclusion and exclusion criteria were taken up for the study. Patient’s general and physical examinations were done. On day 0, through inspection if Striae were observed then Manjistha Ghrita and Go-Ghrita were given in alternative manner. Patients were asked to come for follow up on Day 15. The study period was 30 days and on Day 30, patients were examined to check for any changes in Striae. The obtained data were analyzed statistically using Paired T test, UnPaired T test, Wilcoxon test, Mann Witney test, by using SPSS Software. Usage of Manjistha Ghrita gave considerably good results statistically when compared to application of Go-Ghrita as it only helped in reducing the symptoms till the subjects used the medication and there was recurrence of symptoms later.
Kombinasi Tepung Kunyit dengan Berbagai Level Tepung Kacang Tanah Terhadap Performa Produksi Ayam Kub
Authors: Purnamasari Cahya , Telupere Franky M S , Nalley â€ªWilmientje Marlene
Published: February 2023

Penelitian ini bertujuan untuk menguji pemberian campuran tepung kunyit dengan berbagai level tepung kacang tanah terhadap performa produksi ayam KUB. Penelitian ini menggunakan 60 ekor ayam dengan 4 kelompok perlakuan yaitu: P0 (kontrol), P1 0,15% tepung kunyit (TK) dan 5% tepung kacang tanah (TKT) , P2 0,15% TK dan 10% TKT, P3 0,15% TK dan 15% TK. Setiap perlakuan mendapat lima ulangan dan setiap ulangan terdiri dari 3 ekor ayam., pakan perlakuan diberikan selama delapan minggu. Variabel yang diuji adalah konsumsi pakan, pertambahan bobot badan (PBB) dan konversi pakan. Data dianalisis menggunakan one way anova dan jika terdapat perbedaan antar perlakuan, maka dilakukan uji lanjut menggunakan Duncanâ€™s New Multiple Range Test (DMRT). Hasil penelitian menunjukkan bahwa penggunakan kombinasi TK dan TKT berpengaruh nyata (P<0.05) terhadap PBB dan konversi pakan, dan tidak berpengaruh nyata pada konsumsi pakan (P>0.05) dapat disimpulkan bahwa perlakuan dengan pemberian 15% TKT memberikkan respon terbaik.
An 800V End to End SiC Powertrain to Accommodate Extremely Fast Charging
Authors: Deb Naireeta , Singh Rajendra
Published: February 2023

Widespread adoption of electric vehicles has presented the challenges of short range and prolonged charging time. Going forward, extremely fast charging is the only solution to these problems. However, the typical Silicon power electronics supported 400 V electric vehicle powertrain cannot live up to this challenge. Limitations include the huge cable size, heating of equipment due to high current and user safety, to name a few. In this paper, we have analyzed an 800 V EV powertrain using power electronics based on silicon carbide. In order to implement 800 V powertrain, the complete reconsideration of the electrical system is imperative. In this paper we have presented the implementation of Silicon Carbide based Power electronics to operate an 800 V powertrain and evaluate it against the 800 V Si powertrain. Details of drivetrain, inverter, and auxiliary power units in high voltage charging (Megawatt Level) system are presented in this research.
Acceptability of a Hypothetical Reduction in Routinely Scheduled Clinic Visits Among Patients With History of a Localized Melanoma (MEL-SELF): Pilot Randomized Clinical Trial (Preprint)
Authors: Drabarek Dorothy , Ackermann Deonna , Medcalf Ellie , Bell Katy J L
Published: February 2023

BACKGROUND

After treatment for a localized melanoma, patients attend routinely scheduled clinics to monitor for new primary or recurrent melanoma. Patient-led surveillance (skin self-examination with patient-performed teledermoscopy) is an alternative model of follow-up that could replace some routinely scheduled visits.

OBJECTIVE

This study aims to assess the acceptability of a hypothetical reduction in routinely scheduled visits among participants of the Melanoma Self Surveillance (MEL-SELF) pilot randomized clinical trial of patient-led surveillance (intervention) versus usual care (control).

METHODS

Patients previously treated for localized melanoma in New South Wales who were participating in the MEL-SELF pilot randomized clinical trial were asked to respond to a web-based questionnaire at baseline and after 6 months on trial. We used mixed methods to analyze the data. The main outcome of interest was the acceptability of a hypothetical reduction in routinely scheduled visits for melanoma surveillance.

RESULTS

Of 100 randomized participants, 87 answered the questionnaire at baseline, 66 answered the questionnaire at 6 months, and 79 provided a free-text explanation at either time point. At 6 months, 33% (17/51) of the control group and 35% (17/49) of the intervention group indicated that a hypothetical reduction in routinely scheduled visits with all melanoma doctors was at least slightly acceptable (difference in proportions –1%, 95% CI –20% to 17%; P=.89). Participants suggested that prerequisites for a reduction in routinely scheduled visits would include that sufficient time had elapsed since the previous diagnosis without a new primary melanoma or recurrence, an unscheduled appointment could be made at short notice if the patient noticed something concerning, their melanoma doctor had suggested reducing their clinic visit frequency, and patients had confidence that patient-led surveillance was a safe and effective alternative. Participants suggested that a reduction in routinely scheduled visits would not be acceptable where they perceived a very high risk of new or recurrent melanoma, low self-efficacy in skin self-examination and in the use of technologies for the patient-led surveillance intervention, and where they had a preference for clinician-led surveillance. Some patients said that a partial reduction to once a year may be acceptable.

CONCLUSIONS

Some patients may be receptive to a reduction in routinely scheduled visits if they are assured that patient-led surveillance is safe and effective.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry ACTRN12616001716459; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=371865&isReview=true; ClinicalTrials.gov NCT03581188; https://clinicaltrials.gov/ct2/show/NCT03581188

INTERNATIONAL REGISTERED REPORT

RR2-10.1001/jamadermatol.2021.4704
Stigma and Discrimination Against People Living with HIV: A Qualitative Study of Health Provider’s Perspectives (Preprint)
Authors: Goharinezhad Salime , Shakeri Shiva , Soleimanvandi Azar Neda , Tehrani-Banihashemi Arash
Published: February 2023

BACKGROUND

Stigma and discrimination have been identified as the most important obstacles in the effective response to HIV patients' needs, since the beginning of the HIV epidemic. Stigma and discriminatory behaviors in healthcare providers (HCPs) toward people living with HIV (PLWHAs) are a challenge to public health and as well, a barrier to PLWHA's access and seeking health services, and adherence to ART anti-viral treatments.

OBJECTIVE

This study provides insight into stigmatized attitudes and discriminatory behaviors related to HIV/AIDS from the perspective of healthcare in Iran.

METHODS

The Thematic method was used to develop common themes from semi-structured interviews conducted between March 2021 and October 2021. Totally 38 in-depth interviews conducted with healthcare providers who had experience caring for HIV patients. Transcriptions were analyzed by thematic analysis approach. for categorizing conceptually similar themes, MAXQDA 2022 was used for the analysis and coding of the data.

RESULTS

Four main themes emerged from the data analysis, namely: “Social and individual values”, “Inadequate awareness and education”, “Lack of adherence to ethical principles”, and “insufficient policy-making and cultural development”. One of the most frequent codes found in this study was the fear of contracting a disease. In this study, fear was expressed in many different ways in several themes, including: Lack of understanding of the nature of the disease; absence of complete protective equipment; putting family and individual values before health.

CONCLUSIONS

The results show that HIV-positive patients receive stigma and discrimination from the healthcare system for a variety of reasons, and these factors pose a major obstacle to controlling, preventing, and treating HIV/AIDS. Only by addressing the various aspects of this problem and adopting the appropriate policies can it be reduced. In order to address this issue, we must first break the taboo about this disease in society and then educate everyone about how to prevent and protect themselves through the media, schools, and universities.

CLINICALTRIAL

None
El debate sobre la laboralidad del trabajo vía plataformas digitales en Chile y algunos problemas conexos
Authors: Palomo Vélez Rodrigo , Contreras Vásquez Pablo , Jofré Bustos María Soledad , Sierra Herrero Alfredo
Published: February 2023

El presente artículo pretende evaluar, respecto del caso chileno, los problemas jurídicos que plantea el trabajo vía plataformas digitales en la definición de los criterios identitarios de la relación laboral y de las tutelas jurídicas requeridas. No se vislumbra una categoría jurídica dotada de mejores atributos que la subordinación para delimitar el ámbito de aplicación de las normas laborales. Lo que ha de redefinirse son sus técnicas, sus características específicas, con vocación de adaptabilidad a las nuevas realidades del trabajo, como el que se presta mediante plataformas digitales. En efecto, es posible encontrar diversos patrones comunes que apuntan hacia la laboralidad, a través de una reinterpretación de la noción funcional de subordinación: los incentivos para mantener porcentajes altos de aceptación de servicios, el control a través de GPS, la existencia de algoritmos y otras herramientas digitales de control de desempeño, entre otros.

Asimismo, es necesario formular nuevas categorías jurídicas que permitan, por un lado, proyectar tutelas jurídicas específicas viables respecto de nuestro sistema normativo, particularmente frágil en protección laboral y social y, por otro, otorgar certeza jurídica a estas nuevas formas de trabajo, haciendo las distinciones que procedan.

Se trata de una investigación de tipo explicativo, que asumió el pluralismo metodológico como fórmula para someter a validación la hipótesis presentada, lo cual se concretó eminentemente tanto en la discusión bibliográfica como en la exégesis normativa y en el análisis de jurisprudencia.
Biofilm Formation and Prevention of Bacteria Isolated from Fish and Fish Stalls
Authors: Poyrazoğlu Esin , Yaman Fatma
Published: February 2023

Biofilms are structures formed by bacteria in the presence of convenient media. Bacteria protect themselves from chemicals such as ozone, heat, light and chlorine with biofilm structure. Fish is an important food item and it is an environment where bacteria can easily reproduce. Therefore, it is also appropriate for biofilm formation. Biofilm formation in fish and fish stalls is a threat to human health. In this study, bacteria that can grow on fish and fish stalls and their ability to form biofilms and the effect of natural products (rock salt, lemon juice, vinegar) were investigated. In the study, 47 bacterial isolates were obtained from fish and fish stalls and their molecular identifications were made. The biofilm forming abilities of the identified bacteria were determined by qualitative and quantitative analyzes. As a result of the analysis, it was determined that 36 bacterial species formed biofilm. It has been observed that vinegar and lemon juice are effective. However, rock salt was not found to be effective against biofilm forming bacteria.
Morphometric and Meristic Characteristics of Four Scorpaenoid Species from Antalya Bay, Türkiye
Authors: Koca Habil Uğur
Published: February 2023

In this study, fifteen morphometric and nine meristic traits have been examined of the Scorpaena scrofa, Scorpaena elongata, Scorpaena notata, and Helicolenus dactylopterus species from the Antalya Bay. The results showed that the S. scrofa total length ranged from 109.29 to 271.12 mm and was characterized by dark spots on its spinous dorsal spines between the 6th and 11th. In the S. elongata total length was 153.61 to 248.67 mm. On the other hand, S. notata is characterized by a total length of 131.28 to 305.24 mm and supraocular tentacle. In the H. dactylopterus total length was 110.87 to 306.23 mm. The linear length-length relationships and the allometric growth pattern were also investigated. For all species, correlations between fifteen different morphometric measurements showed a significant difference (p <0.05). R2 correlation coefficient was between 0.752 to 0.988 for the S. scrofa, 0.485 to 0.959 for the S. elongata, 0.207 to 0.975 for the S. notata, and, 0.417 to 0.926 for the H. dactylopterus, respectively. Thus, this study may provide useful information for the conservation and sustainable management of these important fish species.
Local Government Authority Over The Licensing and Supervision Of Pertamina Shop's Business
Authors: Yuhana Ersa , Noviades Dhil’s , Repindowaty Harahap Rahayu
Published: February 2023

Abstract

 

The purpose of this research is to determine the Authority of local governments to implement Pertamina Shop Business Licensing and Supervision which is motivated by the Government's desire to realize equitable distribution of Fuel Oil to all regions in Indonesia. The issue raised was related to the role of the Regional Government in implementing the Pertashop program aimed at the scope of the Regency or Village. Provisions related to the implementation of Pertashop still do not provide clear limits of authority by the Central Government and Regional Governments. The results of this study show that the authority over the licensing of the Pertashop program remains the authority of the central government, but still has the involvement of the Regional Government and other bodies in accordance with the provisions of laws and regulations and the concept of regional autonomy. Furthermore, regulations related to pertashop business licensing requirements are further regulated in the regulation...of the Downstream Oil and Gas Regulatory Agency Number 6 of 2015 concerning the Distribution of Certain Types of Fuel Oil and Special Types of Fuel Assignments in Areas Where There are No Distributors.
The Phenomenon of Mitigation in The Contemporary Hail Dialect, a Lexicon of (Fasih Al-‘Ami in The North of Najd by ‘Abd Al-Rahman Al-Suwayda’) as a Model
Authors: Muhammad Magloth Fahd Salem
Published: February 2023

Deletion is one of the most important means of mitigation in the Ha’il dialects, and the hamza in the Ha’il dialects is permissible in which three rulings are permitted: it be reduced, omitted, or replaced by Ya. Most of the deletion of the mitigation in the Ha’il dialects goes as far as deleting the hamza; Because it is from the extreme of the throat, and it is one of the strongest letters, and the substitution of the hamza ya or wawa in the chapter of mitigation is the second level of mitigation in the Ha’il dialects. The research revealed the confusion between the deletion of the hamza and its reduction in the lexicon (Faseh al-Ami in the north of Najd by Abd al-Rahman al-Suwayda). Aspects of mitigation appeared in the Ha’il dialect in five ways: 1- Deletion 2- Reducing the hamza 3- Facilitating the hamza 4- Substitution of a letter with a weaker letter such as ya and waw 5- Expansion of use in the spatial heart section 6- Elimination of convergence of homologous in the chapter on immersion 7- Substitution of a letter of the gender of another letter in the chapter on the heart The slur. This research proceeds according to the descriptive approach, which is based on the analysis of texts in the Hail region. Through the research, objectives emerged, including highlighting the cultural product of Hail, the most prominent linguistic shifts in it, and the reasons for that; And standing on the linguistic and cultural phenomena as a tributary of the tributaries that contribute to the realization of the vision of the Kingdom of Saudi Arabia 2030.