bluuebunny/crossref_metadata_2025 huggingface dataset:
Fibrinolytic Status and Risk of Death After Acute Pulmonary Embolism
Authors: Brailovsky Yevgeniy , Lakhter Vladimir , Newman Joshua , Allen Sorcha , Elkaryoni Ahmed , Desai Parth , Masic Dalila , Bechara Carlos F. , Bontekoe Emily , Hoppensteadt Debra , Lopez John J. , Siddiqui Fakiha , Iqbal Omer , Fareed Jawed , Darki, Amir
Published: March 2023

Background

Acute pulmonary embolism (PE) is a heterogeneous disease process with variable presentation and outcomes. The endogenous fibrinolytic system is a complex framework of regulatory pathways that maintains homeostasis by dissolving overabundant thrombi. We sought to investigate phenotypic profiles of the endogenous fibrinolytic system among patients presenting with acute PE and their impact on mortality.

Methods

We enrolled all consecutive patients with acute PE in our institutional Pulmonary Embolism Response Team registry. We collected blood samples at the time of PE diagnosis and analyzed concentrations of plasminogen activator inhibitor 1 (PAI-1), thrombin-activatable fibrinolysis inhibitor (TAFI), and alpha-2-antiplasmin (A2A). We assessed the association of concentration of fibrinolytic inhibitors and 1-year all-cause mortality and various echocardiographic markers of right ventricular (RV) dysfunction.

Results

There is significant variability of PAI-1, A2A, and TAFI concentrations across the spectrum of PE risk profiles with high PAI-1, low TAFI, and low A2A (herein referred to as a high-risk biomarker profile) correlating with worse PE severity. High-risk biomarker profile correlated with high-risk echocardiographic features of RV dysfunction, including increased RV/left ventricular (LV) ratio, low tricuspid annular plane systolic excursion, and low right ventricular outflow tract velocity time integral. Higher-risk biomarker profile was able to discriminate and independently identify patients at high risk of all-cause mortality (Group 2 HR 6 95% CI 1.3-27.8, Group 3 HR 12, 95% CI 1.7-86).

Conclusions

Further studies are needed to assess the exact pathophysiological link between fibrinolytic status and poor outcome after acute PE and to ascertain the impact of anti-inhibitors of the fibrinolytic system on response to therapy and outcomes after acute PE.
From Rejection to Legitimation: Governing the Emergence of Organized Homeless Encampments
Authors: Przybylinski Stephen
Published: March 2023

This paper analyzes the City of Portland, Oregon's recent zoning code amendment which legalized sanctioned homeless encampments. Drawing from ethnographic fieldwork in Portland, the paper details how the City Government's long-held opposition to homeless camping shifted to a position of acceptance. The paper identifies the state of emergency (SOE) on housing and homelessness as a critical moment for developing not only a legal foundation, but also a social justification, for legalizing encampments as an official shelter strategy. In contrast to research over the past few decades articulating the camp as the realization of punitive sovereign power, the paper suggests the relationality of emergency governance, or “governing-through-emergency,” instead provides an opportunity to legitimate the lived experiences and desires of unhoused people residing in sanctioned encampments. It concludes by warning that, although emergency governance serves as a critical tool to advance the interests of the unhoused, such governing strategies are limited by structural forces producing homelessness more broadly.
The potential of UVC decontamination to prolong shelf-life of par-baked bread
Authors: Debonne Els , Thys Margaux , Eeckhout Mia , Devlieghere Frank
Published: March 2023

The effect of UVC (254 nm) treatment on the mould-free shelf-life of par-baked wholemeal, rye and six-grain bread was examined. Currently, these breads are par-baked, wrapped in high-density polyethylene (HDPE)-foil and transported or stored at room temperature for a couple of days before being full-baked and sold/consumed. Generally, after five days, these breads show signs of mould spoilage. A shelf-life increase in one or more days would already offer immense economical and logistic benefits for the baker or retailer. In this study, the parameters fluence rate (irradiation intensity), fluence (UV dose), distance to the UV-lamp (DTL) and number of layers of a common wrapping HDPE-foil (20 µm) were diversified. The breads were subjected to a UVC treatment (0–2502 mJ/cm²), packed and stored at room temperature for a period of 15 days (21.5 ± 0.8 °C). Similar as for the breads, agar plates with mould spores of Aspergillus niger, Aspergillus montevidensis and Penicillium roqueforti were UVC treated (0–1664 mJ/cm²) and checked daily for visible mould growth during 15 days (25 °C). Aspergillus niger showed the strongest resistance towards UVC, a fluence of 800 mJ/cm² was needed to inhibit growth during 15 days of storage, whereas for P. roqueforti and A. montevidensis, respectively, UV levels of 291 and 133 mJ/cm² were found sufficient. Furthermore, the shelf-life of wholemeal, rye and six-grain bread can be prolonged from 5 to 6, 8 and 9 days, respectively, using 2502 mJ/cm². The effect of higher UVC dosage on shelf-life reached a maximal level and was strongly impacted by the wide spread on data of mould-free shelf-life. The main factors influencing the potential of UV decontamination were the rough bread surface, differences in DTL, the possibility of post-contamination and UV permeability of packaging materials.
Clinical settings, management and factors affecting outcomes in multi and extensively-drug resistant Pseudomonas endophthalmitis
Authors: Ramamurthy Srishti Raksheeth , Joseph Joveeta , Dave Vivek Pravin
Published: March 2023

Purpose

To report the clinical settings, management and factors affecting outcomes in multi-drug resistant (MDR) and extensively-drug resistant (XDR) Pseudomonas endophthalmitis.

Settings

Retrospective, consecutive, non-comparative interventional case series. Cases of MDR and XDR Pseudomonas endophthalmitis from January 2012 to December 2020 treated at our tertiary eye care center were included. Data collected included clinical data, anatomic and functional outcome, isolated micro-organisms, and culture sensitivity.

Results

This study included 29 eyes of 29 patients with MDR/XDR Pseudomonas endophthalmitis. Mean age at presentation was 60.27 ± 14.9 years (median 63). Commonest clinical setting was acute post-operative endophthalmitis in 27 cases (93.1%). Concurrent corneal infiltrate was present in 11 eyes (37.9%). Initial intervention in 19 eyes (65.5%) was vitrectomy, 2 of which underwent endoscopic pars plana vitrectomy. Mean number of interventions was 3.34 ± 1.44 (median 4). Mean follow up was 3.25 ± 3.07 months (median 2). Sensitivity to ceftazidime was 48.28%. All isolates were sensitive to colistin. Mean visual acuity at last follow up in logMAR was 2.64 ± 1.48 (median 3.5). Seven eyes (24.13%) were NPL (nil perception of light) at the last follow up. Two eyes (6.9%) underwent evisceration. Nine eyes (31.03%) had a favourable anatomic and functional outcome. Eyes without a corneal infiltrate at presentation were found to have a favourable anatomic and favourable functional outcome (OR 11.91, P < 0.04, CI 1.08 to 130.93).

Conclusion

Corneal involvement at presentation is associated with poorer outcomes in MDR and XDR Pseudomonas endophthalmitis. There is a potential role of higher newer antibiotics especially colistin in the management of these cases.
The floating hip injury: a descriptive study and case-control analysis
Authors: Wong Mark Y Z , Ghobrial Marios , Han Win M , Alsousou Joseph , Carrothers Andrew , Hull Peter , Chou Daud , Rawal Jaikirty
Published: March 2023

Purpose:

A “floating hip” (FH) injury is a rare injury describing the simultaneous ipsilateral fracture of the femur and pelvis or acetabulum (P/A). We describe our experience with patients presenting with FH injuries and compare them to controls with similar P/A fractures but without femoral involvement.

Methods:

Medical records and radiographs of FH patients and controls presenting to our tertiary centre between 2015 and 2020 were reviewed. Follow-up data from outpatient clinical records were also extracted. The control group were extensively matched by age, sex, body mass index, fracture classification and energy of injury.

Results:

From 1392 recorded P/A fractures, 42 FH cases were identified (average age 39 years, 78.6% males). The most common femoral fracture was the midshaft (35.7%), followed by the neck of femur (26.2%). 90.5% of FH injuries were due to high-energy mechanisms. 64.3% of P/A fractures, and 100% of femoral fractures were managed surgically. Compared to controls, FH cases were more likely to have additional orthopaedic injuries (73.8% vs. 40.5%, p  = 0.002), more total theatre admissions (mean 2.5 vs. 1.19, p  < 0.001), longer hospital stays (28.3 vs. 14.9 days, p  = 0.02), and a higher rates of post-op complications (53.8% vs. 20%, p  = 0.025)

Conclusions:

We report differences in the presentation, management, and outcomes of FH injuries versus controls, even after extensive matching for confounders. These differences may inform future treatment strategies for the FH injury.
Mitral Valve Endocarditis in Patient Awaiting TAVI: A Case Report
Authors: Michael Faith , Farrow Jamie , Main Anthony
Published: March 2023

Background:

The current literature focuses on the risk of infective endocarditis (IE) following transcatheter aortic valve implantation (TAVI). However, the risk of IE in patients waiting for TAVI is not well-studied. We present a unique case of a patient waiting for TAVI with decompensated heart failure who was found to have a large mitral vegetation, and consider risk factors for the development of IE in this population.

Case description:

We report the case of an 85-year-old male with severe aortic stenosis and recurrent small bowel angiodysplasias, requiring frequent blood transfusions and intravenous iron. He presented to a peripheral hospital in decompensated heart failure. Transfer was arranged to our center to expedite TAVI, under the premise that worsening aortic stenosis precipitated his decompensated state. Prior to TAVI, an echocardiogram was done, and demonstrated a 30 × 18 mm mass on the mitral valve with anterior leaflet perforation and severe mitral regurgitation. The findings were consistent with IE, and the TAVI was cancelled. Despite antibiotic therapy, the patient unfortunately deteriorated and palliative care was provided.

Conclusions:

This case highlights the need for further research regarding the risk of IE in patients waiting for TAVI. Current literature focuses on the development and management of IE following TAVI. Clinicians must understand that TAVI candidates have multiple risk factors for IE, including valvular disease, age, and comorbidities. IE should be considered as a possible cause for decompensated heart failure in patients awaiting TAVI.
“Look at Me!”: The Public and Digital Political Campaigns of People With Disability During Chile’s Sociopolitical Crisis
Authors: Herrera Florencia , Frei Raimundo
Published: March 2023

In a context of multiple crises, an important number of people with disability competed to participate in drafting a new constitution in a remote Latin American country. Their experience shows how the way of looking at disability is structured. Based on interviews with candidates to be members of the Chilean constitutional convention, the study examines how they react to contemptuous, deindividualizing, and assistencialist ways of looking that devalue, invisibilize, and cancel them. However, both on the streets and in digital networks, they deploy strategies to counteract this “distribution of the sensible.” An adaptative strategy seeks assimilation through a “we are not different” and “we are equally capable” response to looking. A second strategy, based on differentiation, seeks to build recognition of uniqueness, with candidates hoping to receive a look that recognizes them and allows them to position themselves as leaders to follow: “I saw you, I recognize you, I follow you.”
Is virtual nutritional counseling efficacious for cancer patients during the COVID-19 pandemic?
Authors: Baş Dilşat , Sönmez Özlem , Koç Elif Sitre , Celayir Özde Melisa , Hajhamidiasl Ladan , Tontaş Ebru
Published: March 2023

This study investigates the outcomes of virtual nutritional counseling (VNC) for oncology patients during the Covid-19 pandemic. Our study evaluated the nutritional status data of cancer patients at the baseline and after VNC. An oncology dietitian evaluated the patients by video calling each patient via WhatsApp and sent an individual nutrition diet plan and recommendations via e-mail. Patient-Generated Subjective Global Assessment (PG-SGA) was used as a screening and evaluation tool to assess nutritional status. A total of 157 patients with a mean age of 55.8 ± 14.7 ( r = 19–89) were included in the study. Researchers detected at least one nutrition-related sign in 77.7% of patients. After the VNC and based on the final PG-SGA assessments, 62.2% of the patients whose baseline PG-SGA Score-B improved to Score-A, 12.5% with a baseline PG-SGA Score-C improved to Score-A and 54.2% with a baseline Score-C improved to a Score-B ( χ2 = 55,000, P < 0.001). Based on the number of VNCs, the improvement in malnutrition status following two sessions and three or more sessions was found to be 17.6% and 35.7%, respectively ( P < 0.001). Our results confirm that VNC can improve the nutritional status of cancer patients. Hence, nutritional counseling should be an integral part of oncological treatment.
Covid-19 pandemic effects and responses in the Maasai Mara conservancy
Authors: Chakrabarti Shreya , Ekblom Anneli
Published: March 2023

Local comparisons of effects, responses and mitigations to the Covid-19 pandemic are of vital importance in building a sustainable tourism. This is particularly the case for conservancies in Africa which is largely dependent on international tourism. Qualitative interviews were carried out in the Kenya Maasai Mara Wildlife Conservancies Association (MMWCA)with landowners, lodge managers and staff, tourism operators, community organisations and NGOs between January and May 2021. The MMWCA is an important case study as conservancies pay lease payments to more than 14,528 landowners through tourism revenues. The results show how partner conservancies took different paths in securing payments of leases and salaries by rotating staff, attracting international funding and by targeting domestic tourism. Meanwhile, landowners experimented with alternative economic activities such as cattle herding and diary production. The study shows the strength of MMWCA as a stakeholder partnership to proactively design measures including renegotiation of lease-payments, in soliciting external funding and in re-distributing funding. The positive role of domestic tourism is also stressed. The pandemic brought to the forefront discussions on equity and benefit sharing and on the sustainability of the model itself. Recommendations are given to strengthen possibilities for alternative incomes sources and for a diversification of strategies of the MMWCA partners, including the need to stimulate domestic tourism as a parallel source of income. These recommendations are also relevant to conservation areas across the African continent.
How the COVID-19 pandemic hit crime in Barcelona: Analysis of variation in crime trends
Authors: Díaz-Faes Diego A. , Vidal-Codina Ferran , Segura Anna , Aguilar Raúl , Pereda Noemí
Published: March 2023

Objectives:

To compare the observed and forecasted crime trends in Barcelona, using crime statistics from January 2018 to March 2021.

Methods:

We trained (seasonal) auto-regressive integrated moving average modelling (95% confidence intervals) using daily recorded crimes from January 2018 to February 2020. These models were then used to forecast crime data from March 2020 to March 2021 across four periods (lockdown, summer, fall and winter). Crime data were organized into two categories: property (burglary, theft) and violent crimes (robbery, assault, domestic violence and sexual offenses [rape, assault or abuse]).

Results:

Overall, crime levels for property and violent crimes during lockdown declined sharply from the forecasted levels. Theft, burglary, assault, robbery and sexual offenses exhibited general decreases throughout the study period, with the same sharp declines during the lockdown, progressive recovery in the summer, and steady or slight reductions from fall to March 2021. Only domestic violence differed, reaching the forecasted levels for all periods and surpassing the forecast for summer 2020.

Conclusions:

Our findings show how the pandemic has affected mid-term crime trends. They help to place the measures applied in the last year into context and to determine the most suitable policies to reduce crime during societal change.
Too civil to care? How online hate speech against different social groups affects bystander intervention
Authors: Obermaier Magdalena , Schmid Ursula Kristin , Rieger Diana
Published: March 2023

A large share of online users has already witnessed online hate speech. Because targets tend to interpret such bystanders’ lack of reaction as agreement with the hate speech, bystander intervention in online hate speech is crucial as it can help alleviate negative consequences. Despite evidence regarding online bystander intervention, however, whether bystanders evaluate online hate speech targeting different social groups as equally uncivil and, thereby, equally worthy of intervention remains largely unclear. Thus, we conducted an online experiment systematically varying the type of online hate speech as homophobia, racism, and misogyny. The results demonstrate that, although all three forms were perceived as uncivil, homophobic hate speech was perceived to be less uncivil than hate speech against women. Consequently, misogynist hate speech, compared to homophobic hate speech, increased feelings of personal responsibility and, in turn, boosted willingness to confront.
Exploring Between-Sector Transfers: Why For-Profit University Students Switch to Public Institutions
Authors: Ott Molly , Zimmerman Thomas
Published: March 2023

This study explores the choices and experiences of undergraduates who transfer out of for-profit 4-year universities and matriculate into a public university. Interviews with students who moved from one of seven 4-year for-profit universities to a single public university during Fall 2021 indicated a combination of academic and financial factors that precipitated their decisions to transfer. Specific academic-related issues included lack of alignment between students’ interests and the school's available degrees, quality concerns, and institutional policies and practices that restricted students’ agency in making decisions about their academic program of study. Affordability was also a major consideration for many study participants. Attending the for-profit was a low-cost option initially but changes in aid packages and/or tuition prices motivated them to seek less expensive options elsewhere.
Disaggregated Attendance Demand: Comparing Daily Ticket Purchasers and Season Ticket Holders in K-League 1
Authors: Sung Hojun , Pyun Hyunwoong
Published: March 2023

This study investigates differences in the preferences of daily ticket purchasers and season ticket holders, focusing on outcome uncertainty. Using unique game-level attendance data of both daily ticket purchasers and season ticket holders for every team in the Korean top-tier professional soccer league, we find heterogeneity in demand between daily ticket purchasers and season ticket holders with respect to outcome uncertainty, preference for home team success, team performance, geographical distance between competing teams, and weekend games. Our results suggest that season ticket holders do not care as much about their team's performance and outcome uncertainty as daily ticket purchasers do.
A Clinical Case Study of Solution-Focused Brief Therapy for Young Adult Cancer Patients’ Psychological Distress: Focusing on Positive Emotions
Authors: Zhang Anao , Froerer Adam
Published: March 2023

Psychological distress is highly prevalent among adolescent and young adult (AYA) cancer patients, an age-defined population (15–39) disproportionately impacted by their cancer diagnosis. Solution-focused brief therapy (SFBT) is a strength-based and evidence-supported approach for youth with medical conditions. The use of SFBT in young cancer patients, however, has been rarely described. Building on the broaden-and-build theory of positive emotions, this study describes how SFBT clinicians intentionally foster positive emotions, especially hope, in an AYA cancer patient to foster therapeutic change. We found improvements in the patient’s psychological distress as well as growth in levels of hope both in the immediate post-intervention assessment and in the 2-week follow-up. The findings of the study suggested that SFBT is a promising approach to the unique challenges confronting AYAs with cancer. It was not feasible for this case study to match the sex and racial identities for a therapist with the client’s preference, which is considered a main limitation of this study.
Spontaneous Iliac Vein Ruptures: A Systematic Review
Authors: Kooiman Alexander L. , Bakas Jay M. , van Fessem Joris M. K. , Boellaard Willem P.A. , Cornelissen Sandra A.P. , van Rijn Marie Josee E.
Published: March 2023

Introduction

Spontaneous iliac vein rupture is a rare, but frequently lethal condition. It is important to timely recognize its clinical features and immediately start adequate treatment. We aimed to increase awareness to clinical features, specific diagnostics, and treatment strategies of spontaneous iliac vein rupture by evaluating the current literature.

Methods

A systematic search was conducted in EMBASE, Ovid MEDLINE, Cochrane, Web of Science, and Google Scholar from inception until January 23, 2023, without any restrictions. Two reviewers independently screened for eligibility and selected studies describing a spontaneous iliac vein rupture. Patient characteristics, clinical features, diagnostics, treatment strategies, and survival outcomes were collected from included studies.

Results

We included 76 cases (64 studies) from the literature, mostly presenting with left-sided spontaneous iliac vein rupture (96.1%). Patients were predominantly female (84.2%), had a mean age of 61 years, and frequently presented with a concomitant deep vein thrombosis (DVT) (84.2%). After various follow-up times, 77.6% of the patients survived, either after conservative, endovascular, or open treatment. Endovenous or hybrid procedures were frequently performed if the diagnose was made before treatment, and almost all survived. Open treatment was common if the venous rupture was missed, for some cases leading to death.

Conclusion

Spontaneous iliac vein rupture is rare and easily missed. The diagnose should at least be considered for middle-aged and elderly females presenting with hemorrhagic shock and concomitant left-sided DVT. There are various treatment strategies for spontaneous iliac vein rupture. An early diagnose brings options for endovenous treatment, which seems to have good survival outcomes based on previously described cases.
Femicides and Victim's age-Associated Factors in Peru
Authors: Quispe Antonio M , Roman-Lazarte Victor , Cornelio Deysy K , Florez Yohaida M , Romero Q Abigail , Vargas Lucía , Sedano Claudia A
Published: March 2023

Background. Femicides are an increasing social problem worldwide. In this study, we aim to describe the trend of femicides in the prepandemic decade and characterize the femicide victims and their perpetrators. Methods. We assessed the trend of femicides in Peru during 2010–2019 and performed a cross-sectional study to analyze the femicides reported in 2019 using open data. Results. We analyzed 166 femicides reported in 24/25 regions of Peru in 2019 and calculated a yearly incidence of 1.01 femicides per 100,000 women. This incidence level represents an increase of 38% compared to the mean annual incidence from 2010 to 2018 (0.74 femicides per 100,000 women). Most femicides occurred in urban areas (64%), through strangling/asphyxiation (25.9%), stabbing (23%), and shooting (16%). Most victims were mothers (61%) 30 years old or over (51%). Most perpetrators have had a partner history with their victims (69%), 30 years old or over (62%), employed (57%), and consumed enablers (51%). Our regression analysis observed that the victim's age was associated with the perpetrator's age and partner history. Conclusions. Femicides are endemic in Peru, and the main characteristics of the victims and their perpetrators offer opportunities for tackling this social problem in Peru and similar low- to middle-income countries.
Stakeholders’ Perceptions and Experiences of Animal Assisted Interventions for People Living With Dementia: A Qualitative Evidence Synthesis Protocol
Authors: Zhang Dou , Hennessy Marita , Houghton Catherine
Published: March 2023

Background: Dementia is a priority public health issue globally. Behavioral and psychological symptoms of dementia (BPSD) lead to low quality of life (QoL) for people living with dementia and can also cause distress amongst their caregivers. To date, the effectiveness of pharmacological treatments for dementia have had limited. Animal assisted intervention (AAI) has become a popular non-pharmacological therapy and psychosocial intervention, and can have positive effects on mood, social behavior, physical activity and QoL of people living with dementia. The factors influencing the delivery of AAI remain underexplored. The aim of this review is to synthesize qualitative research regarding stakeholders’ perceptions and experiences of AAI for people living with dementia in community settings. Methods: We will systematically search nine databases/platforms. Two reviewers will independently screen the titles, abstracts and full texts; the process will be reported following PRISMA guidance. Data from included studies will be extracted according to a specifically designed form. Three reviewers will independently appraise the methodological quality of studies using the Critical Appraisal Skills Program qualitative checklist. We will analyze data following thematic synthesis. GRADE-CERQual will be applied to assess confidence in the findings. The research team will engage in reflexivity throughout all review stages of process through regular meetings/discussions. A Public and Patient Involvement (PPI) contributor will be included to oversee and provide advice on the QES process. Discussion: AAI is a potentially valuable for improving mood and reducing BPSD for people living with dementia. However, the perceptions and experiences of stakeholders and factors influencing the implementation of AAI for people living with dementia are not clear. This qualitative evidence synthesis will significantly contribute to the evidence base. It will identify factors and recommendations for AAI guidance, and have clinical and social implications of improving the well-being of people living with dementia and their caregivers.
The effect of cilostazol on the platelet-derived growth factor-beta/beta isoform reduction on venous hyperplasia in an experimental balloon-induced injury model
Authors: Laparra-Escareño Hugo , Ortega-Gómez Alette , Zentella-Dehesa Alejandro , Manzo-Merino Joaquin , Vergara-Ascencio Carlos Acxel , Antuñano-Blanco Maria del Carmen , Lopez-Santacruz Jose Roberto , Montalvo-Jave Eduardo Esteban , Anaya-Ayala Javier E. , Lozano-Corona Rodrigo , Hinojosa Carlos A.
Published: March 2023

Background

Intimal hyperplasia is the response to endothelial injury. Platelet-derived growth factor is released early and favors the formation of intimal hyperplasia. Although multiple treatments, from open surgery to endovascular techniques, have been used they remain controversial. There is currently interest in developing pharmacological strategies to address this pathology. Local vascular inflammation induced by vessel barotrauma generates intimal hyperplasia due to mechanical stress over the venous endothelium. Cilostazol is a selective phosphodiesterase type 3 (PDE3) selective inhibitor with a regulatory effect over intimal hyperplasia. The objective was to investigate cilostazol’s role in inhibiting smooth muscle cell proliferation due to changes in the expression and release of PDGF-BB isoform and the effect on developing IH using an experimental model of vascular barotrauma (balloon-induced injury model).

Methods

We included 12 New Zealand rabbits. The balloon-induced injury model (BIIM) and experimental group cilostazol (20 mg/kg/day) included 6 rabbits each. Contralateral veins from 6 rabbits used in BIIM model has been taken as control group. We measured and compared the expression of PDGF-BB and the development of IH. A pathologist board chooses a PDGFRα antibody to localized its expression by immunohistochemistry analysis. Subsequently, using an automated immunohistochemical staining machine, the PDGFR expression was evaluated using a Zeiss Primo Star 4 light microscope.

Results

The measurement obtained in the intimal layer was: 126.12 μm2 in the CG, 232 μm2 in the BIIM group, and 178 μm2 in the EG. A statistically significant difference was observed. Baseline serum concentrations of PDGF-BB in the BIIM group were 0.22 pg/mL. At 12 h 0.42 pg/mL, and 0.17 pg/mL at seven days. In the experimental group, the basal levels were 0.33 pg/mL. With the use of cilostazol, a lower peak was obtained at 12 h (0.08 pg/mL). This difference was statistically significant.

Conclusions

Cilostazol induced a significant reduction of IH caused by barotrauma in the venous endothelium, which correlates with decrease in the PDGF-BB in serum. This could be attributed to the pharmacologic effect on PDGFR expression.
What motivates teachers to lead? Examining the effects of perceived role expectations and role identities on teacher leadership behaviour
Authors: Chen Wen-Yan
Published: March 2023

The development of teacher leadership is closely intertwined with the transformation of teacher roles. However, few studies have investigated how this concept, first developed in North America, is affected by teachers’ role identities (RIs) in an Asian context. To this end, this study aimed to examine the effects of teachers’ perceived role expectations (PREs) and RIs on their leadership behaviour. The sage teacher, professional teacher and labourer teacher framework was used for analysis, and 498 junior high school teachers in Taiwan participated in a survey. Structural equation modelling and bootstrap analysis were employed to analyse the data. The results showed that teachers’ PREs as professional and sage teachers were more significant than for labourer teachers. Their RIs also presented the same pattern. Moreover, although teacher leadership is closely related to the development of teacher professionalism, of the three types of teacher roles, only the PRE and RI of the sage teacher can significantly motivate teachers to lead in direct and indirect ways.
The lifetime burden following stroke: Long term impact of stroke on survival and quality of life
Authors: Cheon Soyeon , Li Chung-Yi , Jeng Jiann-Shing , Wang Jung-Der , Ku Li-Jung Elizabeth
Published: March 2023

Background:

The absolute burden of stroke in Korea is ever growing. Many studies have explored the outcomes of mortality, quality of life (QOL), and/or economic burden with limited periods of observation. Relatively few have addressed the lifetime outcomes that are estimated beyond the limited observation period of study samples.

Aims:

By combining QOL and the survival functions over a lifetime horizon, our aims were to estimate the quality-adjusted life expectancy (QALE) and loss-of-QALE of patients with ischemic and hemorrhagic stroke in South Korea, and to compare them between genders.

Methods:

The survival function of stroke patients (n = 13,994) was estimated by the Kaplan–Meier’s method from the National Health Insurance Service-National Sample Cohort of Korea (2002–2015), and then extrapolated to lifetime through a rolling-over algorithm. The QOL measurements, assessed by EuroQol 5-dimension (EQ-5D) questionnaire, of stroke patients (n = 474) were extracted from the Korea Health Panel (KHP, 2008–2018) to estimate the QALE. All stroke patients were categorized by sex and two types of stroke: ischemic and hemorrhagic. Age-, sex-, and calendar year-matched referents were simulated from the Korean life tables to be integrated with the general population’s QOL from the KHP to estimate the QALE of the referents. We calculated the loss-of-QALE by comparing the above two sets of QALE.

Results:

The QALE and loss-of-QALE for ischemic stroke were 10.8 and 6.1 QALYs (quality-adjusted life years), respectively, and 14.0 and 9.0 QALYs for hemorrhagic stroke. The loss-of-QALE in men was 3.0 QALYs larger than that of women with hemorrhagic stroke (p < 0.05), while the difference for ischemic stroke was much smaller and statistically insignificant at 0.6 QALYs.

Conclusions:

The lifetime impact of stroke in Korea is large, especially for males who survived hemorrhagic stroke. Future studies assessing the lifetime needs for long-term care of stroke patients are warranted to quantify the burden of stroke from the societal perspective.
A contrastive study of discoursal emotions between China’s and American newspapers from the perspective of Socio-emotional Theory: The case of the reports on Hong Kong National Security Law
Authors: Peng Zhuo , Hou Jianbo
Published: March 2023

At present, there is an emotional turn in news researches, however, there are not many theories dedicated to the studies of emotions in news discourse. Therefore, by employing corpus analysis, this paper proposes Socio-emotional Theory, and contrasts the emotions in the news discourse on Hong Kong National Security Law between China’s and American newspapers. The results show that as for the themes of emotional discourse, China’s newspapers emphasize national security, social stability, anti-interference in China’s internal affairs, the positive roles of the law, the destructive nature of Hong Kong separatists, and their unreasonable resistance to the law; while American newspapers highlight their worry and fear about the law. Secondly, in terms of the distribution of emotional semantic categories, China’s newspapers talk more about confidence and happiness; however, American newspapers display more fear, sadness, worry, anger, and disappointment. As for ideologies, China’s newspapers show support for the law with less worry, while American newspapers display their opposition to the law with worry and anger, and these differences in ideologies actually reflect the conflict between China’s Democratic Centralism and western Populism. This study can provide enlightenment for the construction of a harmonious international discourse system, expand the ontological components and interpretation boundaries of discourse analysis theories, and promote the researches on emotions of news discourse.
Change in capitate shift after osteotomy for distal radial fracture malunion
Authors: Johnson Nick A. , Simcock Gar-Ling , Rye Dupinderjit , Dias Joseph J.
Published: March 2023

Loss of anterior tilt after a distal radial fracture can lead to carpal malalignment, which may cause functional impairment. The aim of this study was to establish whether distal radial osteotomy for malunion, which primarily restores the dorsal tilt, will also improve carpal malalignment as measured by capitate shift. Radiographs of 67 patients who underwent osteotomy after malunion of a distal radial fracture were reviewed. Measurements of capitate shift and dorsal tilt were recorded. Linear regression modelling was used to assess the relationship between dorsal tilt and capitate shift. Change in capitate shift was strongly associated with change in dorsal tilt following osteotomy. This relationship was maintained on long-term radiographs. Capitate shift is strongly related to dorsal tilt following a distal radial fracture. Correcting the dorsal tilt during an osteotomy, therefore, will improve capitate shift and carpal malalignment. Capitate shift is unrelated to age, sex and is easy to visually assess.

Level of evidence: IV
Updated Psychosocial Surveys With Continuous Glucose Monitoring Items for Youth With Type 1 Diabetes and Their Caregivers
Authors: Shapira Amit , Chen Charlotte W. , Volkening Lisa K. , Laffel Lori M.
Published: March 2023

Aim:

We added items relevant to continuous glucose monitoring (CGM) to the Diabetes Family Conflict Scale (DFC), Diabetes Family Responsibility Questionnaire (DFR), and Blood Glucose Monitoring Communication Questionnaire (GMC) and evaluated the psychometric properties of the updated surveys.

Research Design and Methods:

Youth with type 1 diabetes who recently started CGM and their parents completed the updated surveys and additional psychosocial surveys. Medical data were collected from self-reports and review of the medical record.

Results:

Youth (N = 114, 49% adolescent girls) were aged 13.3 ± 2.7 years and had mean glycated hemoglobin (HbA1c) 7.9 ± 0.9%; 87% of them used pump therapy. The updated surveys demonstrated high internal consistency (DFC youth: α = .91, parent: α = .81; DFR youth: α = .88, parent: α = .93; and GMC youth: α = .88, parent: α = .86). Higher youth and parent DFC scores (more diabetes-specific family conflict) and GMC scores (more negative affect related to glucose monitoring) were associated with more youth and parent depressive symptoms ( r = 0.28-0.60, P ≤ .003), more diabetes burden ( r = 0.31-0.71, P ≤ .0009), more state anxiety ( r = 0.24 to r = 0.46, P ≤ .01), and lower youth quality of life ( r = −0.29 to −0.50, P ≤ .002). Higher youth and parent DFR scores (more parent involvement in diabetes management) were associated with younger youth age (youth: r = −0.76, P < .0001; parent: r = −0.81, P < .0001) and more frequent blood glucose monitoring (youth: r = 0.27, P = .003; parent: r = 0.35, P = .0002).

Conclusions:

The updated DFC, DFR, and GMC surveys maintain good psychometric properties. The addition of CGM items expands the relevance of these surveys for youth with type 1 diabetes who are using CGM and other diabetes technologies.
Dispersion of Manganese Dioxide Particles Using Anionic Technol PG and Sodium Cholate in the Preparation for Application as Films on Substrates
Authors: Uchida Noriyuki , Yanagi Masayoshi , Hamada Hiroki
Published: March 2023

Manganese dioxide (MnO2) is widely used in cosmetics and self-cleaning materials because of the high refractive index and photocatalytic activity of this compound. In the present work, the surfaces of MnO2 particles were coated with a commercially available anionic phospholipid mixture, Technol PG, and sodium cholate(SC). These coated particles were readily dispersed in water and subsequently applied as films onto glass substrates by drop-casting.
Spontaneous epidural and subdural hematomas of the spine: Review of anatomy and imaging findings
Authors: Perillo Teresa , Vitiello Alessio , Carotenuto Barbara , Perrotta Marianna , Serino Antonietta , Manto Andrea
Published: March 2023

Spontaneous epidural (SEH) and subdural hematomas (SSH) of the spine are a rare cause of spinal injury and morbidity. They often present in the emergency setting, though magnetic resonance imaging is the gold-standard for diagnosis. Knowledge of anatomy, and in particular of the dural layers of the spine, is crucial to understand the location of SEH and SSH and their relationship with spinal structure. In this pictorial review, we aim to explain imaging features of the SEH and SSH, and to rule out their main differential diagnosis.
Comparison of post contrast fluid attenuated inversion recovery, 3D T1-SPACE, and T1W MRI sequences with fat suppression in the diagnosis of infectious meningitis
Authors: Mishra Satyakam , Naik Suprava , Bhoi Sanjeev Kumar , Kumar Mukesh , Deep (Bag) Nerbadyswari , Dey Anupam , Mohakud Sudipta , Mahapatro Samarendra
Published: March 2023

Objective

To assess the usefulness of post contrast Fluid attenuated inversion recovery (FLAIR), 3D T1-SPACE, and T1W magnetic resonance imaging (MRI) sequences with fat suppression in diagnosis of infectious meningitis.

Methods

75 patients with clinical suspicion of meningitis were evaluated with post contrast FLAIR (PC-FLAIR), post contrast T1-SPACE (PC-T1-SPACE), and post contrast T1WI (PC-T1WI). Sensitivity, specificity, positive predictive value, and negative predictive value of individual sequences were assessed.

Results

The sensitivity of PC-FLAIR (88.4%) was greater than PC-T1-SPACE (85.5%) and PC-T1WI (82.6%), considering cerebrospinal fluid (CSF) analysis as gold standard ( p < 0.05). Kappa inter-rater agreement between two radiologists was 0.921 for PC-T1-SPACE, 0.921 for PC-T1WI, and 1.0 for PC-FLAIR with a p value <0.05. Both PC-T1-SPACE and PC-FLAIR performed equally in sulcal space enhancement. PC-T1-SPACE and PC-T1WI performed better in evaluation of pachymeningeal enhancement, ependymal enhancement in cases of ventriculitis, whereas PC-FLAIR was more sensitive in assessment of basal cistern enhancement and enhancement along the cerebellar folia.

Conclusion

Meningeal enhancement could be better appreciated in PC-FLAIR image than PC-T1WI and PC-T1-SPACE. Enhancement in PC-T1-SPACE was comparable to that of PC-T1WI. Being a T1 based spin echo sequence, PC-T1-SPACE has all the advantages of PC-T1WI in addition to its ability to differentiate meningeal enhancement from leptomeningeal vessels. Hence, PC-T1WI can be replaced by PC-T1-SPACE and PC-FLAIR can be added to routine MRI protocol in suspected case of meningitis.
Atypical thrombophlebitis patterns in head and neck infections
Authors: George Elizabeth , Callen Andrew L , Glastonbury Christine M
Published: March 2023

Thrombophlebitis is a known complication of head and neck infection, which can result in propagation of infected thrombi and associated complications. While antegrade/downstream propagation of thrombus is well described—the Lemierre syndrome—thrombophlebitis can spread in atypical patterns which has specific diagnostic and treatment considerations. In this series, we highlight 6 cases of atypical thrombophlebitis patterns complicating head and neck infection, 5 of which extend intracranially. Through these pathways, head and neck infections such as oral cavity, oropharynx, or skin can be the culprit of remote, including intracranial, complications, which may be overlooked. Furthermore, understanding pathways of venous drainage and communication can help accurately diagnose thrombophlebitis patterns and associated complications.
Predictors of Outcome After Surgical Decompression for mild degenerative Cervical Myelopathy -A Systematic Review
Authors: Khosravi Sepehr , Farahbakhsh Farzin , Hesari Marjan , Shahmohammadi Alireza , Aliakbargolkar Alireza , Baigi Vali , Eskandari Zahra , Ghodsi Zahra , Harrop James , Rahimi-Movaghar Vafa , Ghodsi Seyed Mohammad
Published: March 2023

Study Design

Systematic Reviews.

Objectives

To investigate predictors of surgical outcomes for mild Degenerative Cervical Myelopathy (DCM) by reviewing all related studies conducted at this point.

Methods

An electronic search was carried out in PubMed, EMBASE, Scopus, and Web of Science until June 23, 2021. Full-text articles reporting surgical outcome predictors of mild DCM cases were eligible. We included studies with mild DCM which was defined as a modified Japanese Orthopaedic Association score of 15 to 17 or a Japanese Orthopaedic Association score of 13 to 16. Independent reviewers screened all the records, and discrepancies between the reviewers were solved in a session with the senior author. For risk of bias assessment, RoB 2 tool was used for randomized clinical trials and ROBINS-I for non-randomized studies.

Results

After screening 6 087 manuscripts, only 8 studies met the inclusion criteria. Lower pre-operative mJOA scores and quality-of-life measurement scores were reported by multiple studies to predict better surgical outcomes compared to other groups. High-intensity pre-operative T2 magnetic resonance imaging (MRI) was also reported to predict poor outcomes. Neck pain before intervention resulted in improved patient-reported outcomes. Two studies also reported motor symptoms prior to surgery as outcome predictors.

Conclusion

Lower quality of life before surgery, neck pain, lower pre-operative mJOA scores, motor symptoms before surgery, female gender, gastrointestinal comorbidities, surgical procedure and surgeon’s experience with specific techniques, and high signal intensity of cord in T2 MRI were the surgical outcome predictors reported in the literature. Lower Quality of Life (QoL) score and neck prior to surgery were reported as predictors of the more improved outcome, but high cord signal intensity in T2 MRI was reported as an unfavorable outcome predictor.
Comparison of intra-articular lumbar facet joint injection of platelet-rich plasma and steroid in the treatment of chronic low back pain: A prospective study
Authors: Singh Chandan , Yadav Sanjay , Loha Sandeep , Prakash Shashi , Paswan Anil Kumar
Published: March 2023

Study design: Prospective randomized clinical study. Purpose: To compare the effectiveness and safety of intra-articular platelet-rich plasma (PCP) and steroid along with radiofrequency ablation (RFA) in the treatment of chronic low back pain (LBP) due to facet joint arthropathy. Overview of literature: Facet joint pathology is an important cause of LBP—15–30% of all LBP cases. Lumbar intra-articular PRP is a relatively new method in the treatment of LBP. PRP stimulates the cells involved in regeneration. Hence, it seems a suitable option for the treatment of lumbar facet joint syndrome. Methods: We evaluated the efficacy and safety of facet joint injections in LBP secondary to facet joint arthropathy. Chronic LBP for ≥3 months (visual analogue scale (VAS) > 4), failed conservative treatment, no neurological deficit, unilateral facet joint pain, focal tenderness with hyperextension pain, and relief by diagnostic medial branch block were included. Patients were randomly allocated to Group S: Steroid (Triamcinolone) + RFA or Group P: PRP + RFA or Group R: 0.9% saline + RFA as control. Demographic, clinico-radiological, and outcome parameters were recorded till 6 months. Data were analyzed using SPSS and p < 0.05 was considered significant. Results: We studied 45 patients (n = 15 in each group) in the final analysis. Mean age was 45.7 ± 13.6 years and 60% were females in all groups. VAS decreased to 1.6 ± 0.8 (Group S) and 3.2 ± 0.8 (Group P) on day 1 ( p < 0.05). At 3 and 6 months, VAS reduced more in Group P (0.47 ± 0.5; 0.07 ± 0.2) versus Group S (2.53 ± 0.5; 3.07 ± 0.2) ( p < 0.001). Mean Oswestry Disability Index (ODI) score at baseline was 72.8 ± 7.6 (all groups). At 1 month, Group S (17.2 ± 3.2) showed better improvement than Group P (23.2 ± 3.1) ( p < 0.05). At 6 months, Group P (8.9 ± 1.2) had more decrease in ODI than Group S (29.0 ± 2.1) ( p < 0.001). NSAIDs usage and Patient Satisfaction Score (PSS) were significantly better at 6 months in Group P than Group S ( p < 0.01; p < 0.05, respectively). Conclusion: Both PRP and corticosteroid injections were determined to be effective and safe for the treatment of lumbar facet joint syndrome after 6 months of follow-up. However, autologous PRP may be a superior treatment option for longer efficacy.