bluuebunny/crossref_metadata_2025 huggingface dataset:
PHYSICS WITH COSMIC NEUTRINOS, PEV TO ZEV
Authors: WEILER THOMAS J.
Published: November 2003

Neutrinos offer a particularly promising eye on the extreme Universe. Neutrinos are not attenuated by intervening radiation fields such as the Cosmic Microwave Background, and so they are messengers from the very distant and very young phase of the universe. Also, neutrinos are not deflected by cosmic magnetic fields, and so they should point to their sources. In addition, there are particle physics aspects of neutrinos which can be tested only with cosmic neutrino beams. After a brief overview of highest-energy cosmic ray data, and the present and proposed experiments which will perform neutrino astronomy, we discuss two particle physics aspects of neutrinos. They are possible long-lifetime decay of the neutrino, and a measurement of the neutrino-nucleon cross-section at a CMS energy orders of magnitude beyond what can be achieved with terrestrial accelerators. Measurement of an anomalously large neutrino cross-section would indicate new physics (e.g. low string-scale, extra dimensions, precocious unification), while a smaller than expected cross-section would reveal an aspect of QCD evolution. We then discuss aspects of neutrino-primary models for the extreme-energy (EE) cosmic ray data. Primary neutrinos in extant data are motivated by the directional clustering at EE reported by the AGASA experiment. We discuss the impact of the strongly-interacting neutrino hypothesis on lower-energy physics via dispersion relations, the statistical significance of AGASA directional clustering, and the possible relevance of the Z-burst mechanism for existing EE cosmic ray data.
EXPERIMENTS FOR NEUTRINOLESS DOUBLE-BETA DECAY
Authors: ELLIOTT STEVEN R.
Published: November 2003

The recent neutrino oscillation experimental results indicate that at least one neutrino has a mass greater than 50 meV. The next generation of double-beta decay experiments will very likely have a sensitivity to an effective Majorana neutrino mass below this target. Therefore this is a very exciting time for this field of research as even null results from these experiments have the potential to elucidate the nature of the neutrino.
DEVELOPMENT OF FUZZY REGRESSION MODELS USING GENETIC ALGORITHMS
Authors: MOGILENKO A. V. , PAVLYUCHENKO D. A. , MANUSOV V. Z.
Published: November 2003

This paper presents the comparative study for fuzzy regression model using linear programming and fuzzy regression model using genetic algorithms. Two cases were considered: crisp X – crisp Y and crisp X – fuzzy Y. Simulation was carried out with a tool developed in MATLAB.
ACCURACY, COMPREHENSIBILITY AND COMPLETENESS EVALUATION OF A FUZZY EXPERT SYSTEM
Authors: MEESAD PHAYUNG , YEN GARY G.
Published: November 2003

Using optimization tools such as genetic algorithms to construct a fuzzy expert system (FES) focusing only on its accuracy without considering the comprehensibility may not result in a system that produces understandable expressions. To exploit the transparency characteristics of FES for reasoning in a higher-level knowledge representation, a FES should provide high comprehensibility while preserving its accuracy. The completeness of fuzzy sets and rule structures should also be considered to guarantee that every data point has a response output. This paper proposes some quantitative measures for a FES to determine the degree of the accuracy, the comprehensibility of the fuzzy sets, and the completeness of fuzzy rule structure. These quantitative measures are then used as a fitness function for a genetic algorithm in optimally refining a FES.
SHANNON INFORMATION AND ENTROPY SQUEEZING OF TWO FIELDS PARAMETRIC FREQUENCY CONVERTER INTERACTING WITH A SINGLE-ATOM
Authors: ABDEL-ATY MAHMOUD , OBADA ABDEL-SHAFY F. , ABDALLA M. SEBAWE
Published: November 2003

In terms of a new Hamiltonian we introduce a modified Jaynes–Cummings model to represent the interaction between a two-level atom and two electromagnetic fields injected simultaneously within a perfect cavity. The field–field interaction is assumed to be in the frequency converter form. Exact expressions of the dynamical operators is given by solving the equations of the motion in the Heisenberg picture. The entropy squeezing is examined in the framework of Shannon information entropy. Using the entropic uncertainty relation, one can be able to show that there is a new kind of quantum squeezing in the entropy.
REDUCED ENTANGLEMENT FOR QUANTUM GAMES
Authors: ZHANG LI , HOGG TAD
Published: November 2003

Quantum generalizations of conventional games exploit entangled states to improve performance. With many players, quantum games can require entangling many states. Such entanglement is difficult to implement, especially if the states must be communicated over some distance. To simplify possible implementations, we examine some quantum versions of social dilemma games and show their use of entanglement can be substantially reduced by randomly replacing some of the entangled states by unentangled ones. For the example of public goods games, we identify a unique Nash equilibrium invariant with respect to the amount of this replacement. We also show players obtain no advantage from adding more entanglement to states which they control. With many players, a fairly small number of entangled states can give nearly as good performance as using the full number of such states.
SCALING OF ENTANGLEMENT IN FINITE ARRAYS OF EXCHANGE-COUPLED QUANTUM DOTS
Authors: WANG JIAXIANG , KAIS SABRE
Published: November 2003

We present a finite-size scaling analysis of the entanglement in a two-dimensional arrays of quantum dots modeled by the Hubbard Hamiltonian on a triangular lattice. Using multistage block renormalization group approach, we have found that there is an abrupt jump of the entanglement when a first-order quantum phase transition occurs. At the critical point, the entanglement is constant, independent of the block size.
Myelodysplastic Syndrome
Authors: Mufti Ghulam , List Alan F. , Gore Steven D. , Ho Aloysius Y.L.
Published: November 2003

The last decade has witnessed a multistep evolution in the understanding of the natural history, clinical manifestations, and some of the molecular mechanisms that underlie the ineffective hematopoiesis and leukemic transformation in the myelodysplastic syndrome (MDS). The international prognostic scoring system, FAB, and WHO classifications have helped define specific subgroups with their characteristic cytogenetic, molecular and immunological abnormalities. Until recently the mainstay of the treatment has been entirely supportive with blood and platelet transfusions. What is increasingly manifest now is the considerable excitement generated by the emergence of novel therapeutic strategies based on painstaking research findings from the laboratories.

In Section I, Dr. Alan List reviews the therapeutic strategies with the specific emphasis on the relevance of molecular mechanism of apoptosis and targeted therapies using small molecules. Of particular interest is the excitement surrounding the clinical benefit obtained from potent immunomodulatory derivative (IMiD) of thalidomide CC5013. The review provides an update of the role of small molecule inhibitors of VEGF receptor tyrosine kinase, arsenic trioxide, oral matrix metalloprotease inhibitors, farnesyl transferase inhibitors, and imatinib mesylate in the treatment of MDS subgroups.

In Section II, Dr. Steven Gore describes the results of clinical trials of inhibitors of DNA methylation such as 5 azacytidine (5 AC) and 5-aza 2-deoxycytidine (Decitabine). The review also provides an update on the rationale and results obtained from the combination therapy using histone deacetylases (HDAC) and DNA methyltransferase inhibitors in the treatment of MDS.

In Section III, Professor Ghulam Mufti and Dr. Aloysius Ho describe the role of bone marrow transplantation with particular emphasis on recent results from reduced-intensity conditioned transplants, exploiting the graft versus leukemia effect without significant early treatment-related mortality. The section provides an update on the results obtained from the manipulation of the host’s immune system with immunosuppressive agents such as ALG and/or cyclosporine A.
Immunodeficiency Disorders
Authors: Cooper Max D. , Lanier Lewis L. , Conley Mary Ellen , Puck Jennifer M.
Published: November 2003

Hematological complications occur frequently in patients with both primary and secondary immunodeficiency disorders. Anemia, thrombocytopenia or leukopenias may bring these individuals to the attention of hematologists. Conversely, evidence suggesting a lymphoproliferative disorder may be the cause for referral. This session will provide an update on the diagnosis and treatment of immunodeficiency diseases ranging from isolated defects in antibody production to the severe combined immunodeficiencies (SCID).

Immunodeficiency diseases have traditionally been defined as defects in the development and function of T and B cells, the primary effector cells of specific cellular and humoral immunity. However, it has become increasingly evident that innate immune mechanisms contribute greatly to host defense, either through acting alone or by enhancing specific T and B cell responses.

In Section I, Dr. Lewis Lanier reviews the burgeoning information on the extensive families of activating and inhibitory immunoreceptors that are expressed on NK cells, dendritic cells, T and B cells, and phagocytic cells. He provides an overview on the biological functions of these receptors in host defense.

In Section II, Dr. Mary Ellen Conley defines the spectrum of antibody deficiency disorders, the most frequently occurring types of primary immunodeficiencies. She covers the different defects in B-cell development and function that lead to antibody deficiencies, and includes diagnosis and therapy of these disorders.

In Section III, Dr. Jennifer Puck discusses the diagnosis and treatment of the different types of SCID. She describes the genetic basis for SCID, and the benefits, pitfalls, and complications of gene therapy and bone marrow transplantation in SCID patients.
Hematopoietic Cell Transplantation for Benign Hematological Disorders and Solid Tumors
Authors: Storb Rainer F. , Lucarelli Guido , McSweeney Peter A. , Childs Richard W.
Published: November 2003

Allogeneic hematopoietic cell transplantation (HCT) has been successfully used as replacement therapy for patients with aplastic anemia and hemoglobinopathies. Both autologous and allogeneic HCT following high-dose chemotherapy can correct manifestations of autoimmune diseases. The impressive allogeneic graft-versus-tumor effects seen in patients given HCT for hematological malignancies have stimulated trials of allogeneic immunotherapy in patients with otherwise refractory metastatic solid tumors. This session will update the status of HCT in the treatment of benign hematological diseases and solid tumors.

In Section I, Dr. Rainer Storb reviews the development of nonmyeloablative conditioning for patients with severe aplastic anemia who have HLA-matched family members. He also describes the results in patients with aplastic anemia given HCT from unrelated donors after failure of responding to immunosuppressive therapy. The importance of leuko-poor and in vitro irradiated blood product transfusions for avoiding graft rejection will be discussed.

In Section II, Dr. Guido Lucarelli reviews the status of marrow transplantation for thalassemia major and updates results obtained in children with class I and class II severity of thalassemia. He also describes results of new protocols for class III patients and efforts to extend HCT to thalassemic patients without HLA-matched family members.

In Section III, Dr. Peter McSweeney reviews the current status of HCT for severe autoimmune diseases. He summarizes the results of autologous HCT for systemic sclerosis, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus, and reviews the status of planned Phase III studies for autologous HCT for these diseases in North America and Europe. He also discusses a possible role of allogeneic HCT in the treatment of these diseases.

In Section IV, Dr. Richard Childs discusses the development and application of nonmyeloablative HCT as allogeneic immunotherapy for treatment-refractory solid tumors. He reviews the results of pilot clinical trials demonstrating graft-versus-solid tumor effects in a variety of metastatic cancers and describes efforts to characterize the immune cell populations mediating these effects, as well as newer methods to target the donor immune system to the tumor.
Realistic Prospects for Stem Cell Therapeutics
Authors: Daley George Q. , Goodell Margaret A. , Snyder Evan Y.
Published: November 2003

Studies of the regenerating hematopoietic system have led to the definition of many of the fundamental principles of stem cell biology. Therapies based on a range of tissue stem cells have been widely touted as a new treatment modality, presaging an emerging new specialty called regenerative medicine that promises to harness stem cells from embryonic and somatic sources to provide replacement cell therapies for genetic, malignant, and degenerative conditions. Insights borne from stem cell biology also portend development of protein and small molecule therapeutics that act on endogenous stem cells to promote repair and regeneration. Much of the newfound enthusiasm for regenerative medicine stems from the hope that advances in the laboratory will be followed soon thereafter by breakthrough treatments in the clinic. But how does one sort through the hype to judge the true promise? Are stem cell biologists and the media building expectations that cannot be met? Which diseases can be treated, and when can we expect success? In this review, we outline the realms of investigation that are capturing the most attention, and consider the current state of scientific understanding and controversy regarding the properties of embryonic and somatic (adult) stem cells. Our objective is to provide a framework for appreciating the promise while at the same time understanding the challenges behind translating fundamental stem cell biology into novel clinical therapies.
Infections in Patients with Hematological Cancer: Recent Developments
Authors: O’Brien Susan N. , Blijlevens Nicole M.A. , Mahfouz Tahsine H. , Anaissie Elias J.
Published: November 2003

One of the most common complications involved in treating patients with hematologic cancer is infection. In many cases there are multiple factors that predispose these patients to infections such as neutropenia induced by therapy or bone marrow involvement, hypogammaglobulinemia, T-cell dysfunction, and mucosal damage. In addition, newer therapies have changed the spectrum of infection that is seen in these patients.

In Section I, Dr. Blijlevens discusses mucosal damage as a major risk factor for complications of cytotoxic chemotherapy. She focuses on mucosal barrier injury (MBI) as manifest in the GI tract and will describe a pathological model to explain MBI, evaluate risk factors for development of this syndrome, explain the relationship between MBI and infection, and discuss treatment and prevention of this injury.

Invasive fungal infections continue to represent a significant problem in patients with hematologic cancer. In Section II, Drs. Anaissie and Mahfouz review the latest developments in the diagnosis, prevention, and management of invasive fungal infections with a focus on a risk-adjusted approach to this problem.

Finally, in Section III, Dr. O’Brien reviews infections associated with newer therapeutic regimens in hematologic cancers. The spectrum of infections has changed with the use of purine analogs and the advent of monoclonal antibodies. The profound T-cell suppression associated with these therapies has led to the emergence of previously rare infections such as cytomegalovirus. An approach to both prophylaxis and management of these infections is discussed.
The Hematologist and Radiation Casualties
Authors: Dainiak Nicholas , Waselenko Jamie K. , Armitage James O. , MacVittie Thomas J. , Farese Ann M.
Published: November 2003

Since the terrorist attack of September 11, 2001, preparation by the health care system for an act of terrorism has been mandated by leaders of governments. Scenarios for terrorist acts involving radioactive material have been identified, and approaches to management (based on past experience from atomic weapons detonations and radiation accidents) have been developed. Because of their experience in managing patients with profound cytopenia and/or marrow aplasia, hematologists will be asked to play a significant role in evaluating and treating victims of mass accidental or deliberate exposure to radiation. This review provides a framework for understanding how radiation levels are quantified, how radiation alters the function of hematopoietic (and nonhematopoietic) cells and tissues, and how victims receiving a significant radiation dose can be identified and managed.

In Section I, Dr. Nicholas Dainiak reviews four components of the Acute Radiation Syndrome: the hematopoietic, neurovascular, gastrointestinal and cutaneous subsyndromes. Clinical signs and symptoms are discussed for exposed individuals at the time of initial presentation (the prodromal phase) and during their course of disease (the manifest illness). In Section II, he presents clinical and laboratory methods to assess radiation doses, including time to onset and severity of vomiting, rate of decline in absolute blood lymphocyte count and the appearance of chromosome aberrations such as dicentrics and ring forms. Potential scenarios of a radiation terrorist event are reviewed, and methods for initial clinical assessment, triage, and early management of the acute radiation syndrome and its component subsyndromes are summarized.

In Section III, Dr. Jamie Waselenko reviews the hematopoietic syndrome, and presents guidelines for the use of cytokine therapy, antibiotics, and supportive care that have been developed by the Strategic National Pharmaceutical Stockpile Working Group. Results of preclinical and clinical growth factor therapy studies with G-CSF, GM-CSF, pegylated G-CSF, SCF, and IL-3 are summarized. When and how potassium iodide should be used after exposure to radioiodines is also reviewed.

In Section IV, Dr. James Armitage describes a narrow “window” of 7 to 10 Gy where therapy with stem cell transplantation may be appropriate. Victims who are candidates for allotransplantation should not have major trauma or significant injury to other (nonhematopoietic) tissues. Rarely, victims may have an identical sibling or autologous stored marrow or blood stem cells, in which case the threshold for transplantation is 4 Gy.

In Section V, Dr. Thomas MacVittie describes new directions for therapy, using cytokines such as IL-7, keratinocyte growth factor, and FLT-3. The potential for combinations of cytokines to enhance hematopoietic recovery is also reviewed.
Thrombotic Disorders: Diagnosis and Treatment
Authors: Schafer Andrew I. , Levine Mark N. , Konkle Barbara A. , Kearon Clive
Published: November 2003

Hematologists are increasingly involved in the diagnosis and management of patients with venous and arterial thromboembolic disorders. There have been major advances in recent years in our understanding of the central role of hypercoagulability in the pathogenesis of thrombosis. This has led to new approaches to the diagnosis of patients at risk for thrombosis and the development of more rational antithrombotic strategies.

In Section I, Dr. Andrew Schafer reviews current concepts of acquired and inherited hypercoagulable states. It is now recognized that most, if not all, patients with venous thromboembolism have a genetic basis for the disorder (“thrombophilia”). The level of lifelong, baseline hypercoagulability in any individual may be determined by the type(s) and number of thrombophilia(s) that are inherited. Clinical episodes of thrombosis are precipitated by acquired thrombogenic triggers, which may be overt (e.g., pregnancy) or subclinical.

In Section II, Dr. Mark Levine discusses the complex problem of thrombosis in patients with cancer. The goals of treating acute venous thromboembolism in cancer patients are to prevent recurrence, minimize the risk of anticoagulant-induced bleeding, and improve quality of life. New developments have improved treatment of venous thromboembolism in these patients, including outpatient therapy and secondary prevention with low-molecular-weight heparin.

In Section III, Dr. Barbara Konkle reviews the diagnosis and management of thrombotic complications associated with pregnancy and hormonal therapy. Patient management is discussed based on data on thrombotic risks associated with hormonal treatment of infertility, pregnancy and the post-partum period in women with and without underlying thrombophilic risk factors.

In Section IV, Dr. Clive Kearon discusses the management of anticoagulation before and after elective surgery. In the past, there has been no consensus on the perioperative management of anticoagulation for patients who require long-term warfarin therapy. This review considers the expected risks and benefits of different approaches to anticoagulation in patients who require warfarin because of atrial fibrillation, a mechanical heart valve, or a history of venous thromboembolism.
Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Authors: Löwenberg Bob , Griffin James D. , Tallman Martin S.
Published: November 2003

The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel drugs into the pipeline of clinical trials that target pathogenetic mechanisms of the disease.

In Section I, Dr. Bob Löwenberg reviews current issues in the clinical practice of the management of adults with AML, including those of older age. Dr. Löwenberg describes upcoming possibilities for predicting prognosis in defined subsets by molecular markers and reviews experimental strategies to improve remission induction and postinduction treatment.

In Section II, Dr. James Griffin reviews the mechanisms that lead to activation of tyrosine kinases by mutations in AML, the consequences of that activation for the cell, and the opportunities for targeted therapy and discusses some examples of developing novel drugs (tyrosine kinase inhibitors) and their effectiveness in AML (FLT3).

In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. Dr. Tallman focuses on the molecular genetics of APL, current curative treatment strategies and approaches for patients with relapsed and refractory disease. In addition, areas of controversy regarding treatment are addressed.
Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism
Authors: Colucci Mario , Binetti Bianca M. , Tripodi Armando , Chantarangkul Veena , Semeraro Nicola
Published: November 2003

The prothrombin gene mutation G20210A is a common risk factor for thrombosis and is associated with increased prothrombin levels. However, the mechanism whereby hyperprothrombinemia predisposes to thrombosis remains unclear. Because thrombin is the physiologic activator of TAFI (thrombin activatable fibrinolysis inhibitor), the precursor of an antifibrinolytic carboxypeptidase (TAFIa), we evaluated the influence of hyperprothrombinemia on fibrinolysis. Thirty-two heterozygous carriers of the G20210A mutation and 30 noncarriers were studied. Plasma fibrinolytic factors and TAFI levels were similar in the 2 groups. Mean lysis time of tissue factor–induced plasma clots exposed to 25 ng/mL exogenous tissue-type plasminogen activator (t-PA) was significantly longer in 20210A carriers than in control donors. This difference disappeared on addition of a specific inhibitor of TAFIa. Determination of thrombin and TAFIa activity, generated during clot lysis, revealed that G20210A mutation was associated with a significant enhancement of late thrombin formation and an increase in TAFI activation. Plasma prothrombin level was highly significantly correlated with both clot lysis time and TAFI activation. The addition of purified prothrombin, but not of factors X or VIIa, to normal plasma caused a concentration-dependent, TAFI-mediated inhibition of fibrinolysis. These findings provide a new mechanism that might contribute to the thrombotic risk in prothrombin 20210A carriers.
Interactions of Aspergillus fumigatus with endothelial cells: internalization, injury, and stimulation of tissue factor activity
Authors: Bezerra Leila M. Lopes , Filler Scott G.
Published: November 2003

Invasive aspergillosis causes significant mortality among patients with hematologic malignancies. This infection is characterized by vascular invasion and thrombosis. To study the pathogenesis of invasive aspergillosis, we investigated the interactions of Aspergillus fumigatus conidia and hyphae with endothelial cells in vitro. We found that both forms of the organism induced endothelial cell microfilament rearrangement and subsequent endocytosis. Conidia were endocytosed 2-fold more avidly than hyphae, and endocytosis was independent of fungal viability. Endocytosed conidia and hyphae caused progressive endothelial cell injury after 4 hours of infection. Live conidia induced more endothelial cell injury than did live hyphae. However, endothelial cell injury caused by conidia was dependent on fungal viability, whereas injury caused by hyphae was not, indicating that conidia and hyphae injure endothelial cells by different mechanisms. Neither live nor killed conidia increased tissue factor activity of endothelial cells. In contrast, both live and killed hyphae stimulated significant endothelial cell tissue factor activity, as well as the expression of tissue factor antigen on the endothelial cell surface. These results suggest that angioinvasion and thrombosis caused by A fumigatus hyphae in vivo may be due in part to endothelial cell invasion, induction of injury, and stimulation of tissue factor activity.
Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes
Authors: Levitus Marieke , Rooimans Martin A. , Steltenpool Jûrgen , Cool Nicolle F. C. , Oostra Anneke B. , Mathew Christopher G. , Hoatlin Maureen E. , Waisfisz Quinten , Arwert Fré , de Winter Johan P. , Joenje Hans
Published: November 2003

Fanconi anemia (FA) is an autosomal recessive syndrome featuring diverse symptoms including progressive bone marrow failure and early occurrence of acute myeloid leukemia. Nine genetic subtypes have been described for FA (A, B, C, D1, D2, E, F, G, and L), all of which have been connected to distinct disease genes, except B. Here we report on 8 unrelated FA patients who were excluded from the known subtypes on the basis of phenotypic correction or genetic data. Four of these cell lines failed to complement each other in somatic cell hybrids and therefore represent a new group, termed FA-I. The remaining cell lines complemented group FA-I but did not complement each other, thus representing a second new group, FA-J. Both FA-I and -J cell lines were capable of forming an FA multiprotein core complex. This complex is required for activation of the FANCD2 protein by mono-ubiquitination, a key downstream event in the FA pathway. In FA-I cells FANCD2 was not mono-ubiquitinated, indicating a defect upstream in the FA pathway, whereas in FA-J cells FANCD2 was mono-ubiquitinated, indicating a downstream defect. Our results suggest that the FA pathway of genome stabilization may be controlled by at least 11 different genes, including FANCI and FANCJ.
Are hsps suitable for indicating stressed states in fish?
Authors: Iwama George K. , Afonso Luis O. B. , Todgham Anne , Ackerman Paige , Nakano Kazumi
Published: November 2003

In response to most stressors, fish will elicit a generalized physiological stress response, which involves the activation of the hypothalamic-pituitary-interrenal axis (HPI). As in other vertebrates, this generalized stress response comprises physiological responses that are common to a wide range of environmental, physical and biological stressors. Recently,several families of heat shock proteins (hsps) have been proposed as indicators of a generalized stress response at the cellular level. Recent findings that hsp levels, in various fish tissues, respond to a wide range of stressors have supported the use of these proteins as indicators of stressed states in fish. However, the cellular stress response can vary, for example,according to tissue, hsp family and type of stressor. This brief overview of these responses in fish asks the question of whether changes in levels and families of hsps can be used as a suitable indicator of stressed states in fish. By casting this question in the context of the well-established generalized physiological stress response in fish, we argue that the use of hsps as indicators of stressed states in fish in general is premature.
Mechanism of tongue protraction in microhylid frogs
Authors: Meyers Jay J. , O'Reilly James C. , Monroy Jenna A. , Nishikawa Kiisa C.
Published: November 2003

High-speed videography and muscle denervation experiments were used to elucidate the mechanism of tongue protraction in the microhylid frog Phrynomantis bifasciatus. Unlike most frogs, Phrynomantishas the ability to protract the tongue through a lateral arc of over 200°in the frontal plane. Thus, the tongue can be aimed side to side,independently of head and jaw movements. Denervation experiments demonstrate that the m. genioglossus complex controls lateral tongue aiming with a hydrostatic mechanism. After unilateral denervation of the m. genioglossus complex, the tongue can only be protracted towards the denervated (inactive)side and the range through which the tongue can be aimed is reduced by 75%. Histological sections of the tongue reveal a compartment of perpendicularly arranged muscle fibers, the m. genioglossus dorsoventralis. This compartment,in conjunction with the surrounding connective tissue, generates hydrostatic pressure that powers tongue movements in Phrynomantis. A survey of aiming abilities in 17 additional species of microhylid frogs, representing a total of 12 genera and six subfamilies, indicates that hydrostatic tongues are found throughout this family. Among frogs, this mechanism of tongue protraction was previously known only in Hemisus and may represent a synapomorphy of Hemisus and Microhylidae.
Biomechanics of ant adhesive pads: frictional forces are rate- and temperature-dependent
Authors: Federle Walter , Baumgartner Werner , Hölldobler Bert
Published: November 2003

Tarsal adhesive pads enable insects to hold on to smooth plant surfaces. Using a centrifuge technique, we tested whether a 'wet adhesion' model of a thin film of liquid secreted between the pad and the surface can explain adhesive and frictional forces in Asian Weaver ants (Oecophylla smaragdina).

When forces are acting parallel to the surface, pads in contact with the surface can slide smoothly. Force per unit pad contact area was strongly dependent on sliding velocity and temperature. Seemingly consistent with the effect of a thin liquid film in the contact zone, (1) frictional force linearly increased with sliding velocity, (2) the increment was greater at lower temperatures and (3) no temperature dependence was detected for low-rate perpendicular detachment forces. However, we observed a strong,temperature-independent static friction that was inconsistent with a fully lubricated contact. Static friction was too large to be explained by the contribution of other (sclerotized) body parts. Moreover, the rate-specific increase of shear stress strongly exceeded predictions derived from estimates of the adhesive liquid film's thickness and viscosity.

Both lines of evidence indicate that the adhesive secretion alone is insufficient to explain the observed forces and that direct interaction of the soft pad cuticle with the surface ('rubber friction') is involved.
Spatial organization of visuomotor reflexes inDrosophila
Authors: Tammero Lance F. , Frye Mark A. , Dickinson Michael H.
Published: November 2003

In most animals, the visual system plays a central role in locomotor guidance. Here, we examined the functional organization of visuomotor reflexes in the fruit fly, Drosophila, using an electronic flight simulator. Flies exhibit powerful avoidance responses to visual expansion centered laterally. The amplitude of these expansion responses is three times larger than those generated by image rotation. Avoidance of a laterally positioned focus of expansion emerges from an inversion of the optomotor response when motion is restricted to the rear visual hemisphere. Furthermore, motion restricted to rear quarter-fields elicits turning responses that are independent of the direction of image motion about the animal's yaw axis. The spatial heterogeneity of visuomotor responses explains a seemingly peculiar behavior in which flies robustly fixate the contracting pole of a translating flow field.
Motor output reflects the linear superposition of visual and olfactory inputs inDrosophila
Authors: Frye Mark A. , Dickinson Michael H.
Published: November 2003

Animals actively seeking food and oviposition sites must integrate feedback from multiple sensory modalities. Here, we examine visual and olfactory sensorimotor interactions in Drosophila. In a tethered-flight simulator, flies modulate wingbeat frequency and amplitude in response to visual and olfactory stimuli. Responses to both cues presented simultaneously are nearly identical to the sum of responses to stimuli presented in isolation for the onset and duration of odor delivery, suggesting independent sensorimotor pathways. Visual feedback does, however, alter the time course of the odor-off response. Based on the physiology of the flight motor system and recent free-flight analyses, we present a hypothetical model to account for the summation or superposition of sensorimotor responses during flight.
Summation of visual and mechanosensory feedback inDrosophilaflight control
Authors: Sherman Alana , Dickinson Michael H.
Published: November 2003

The fruit fly Drosophila melanogaster relies on feedback from multiple sensory modalities to control flight maneuvers. Two sensory organs,the compound eyes and mechanosensory hindwings called halteres, are capable of encoding angular velocity of the body during flight. Although motor reflexes driven by the two modalities have been studied individually, little is known about how the two sensory feedback channels are integrated during flight. Using a specialized flight simulator we presented tethered flies with simultaneous visual and mechanosensory oscillations while measuring compensatory changes in stroke kinematics. By varying the relative amplitude,phase and axis of rotation of the visual and mechanical stimuli, we were able to determine the contribution of each sensory modality to the compensatory motor reflex. Our results show that over a wide range of experimental conditions sensory inputs from halteres and the visual system are combined in a weighted sum. Furthermore, the weighting structure places greater influence on feedback from the halteres than from the visual system.
Learning, odour preference and flower foraging in moths
Authors: Cunningham John Paul , Moore Chris J. , Zalucki Myron P. , West Stuart A.
Published: November 2003

Floral volatiles play a major role in plant–insect communication. We examined the influence of two volatiles, phenylacetaldehyde andα-pinene, on the innate and learnt foraging behaviour of the moth Helicoverpa armigera. In dual-choice wind tunnel tests, adult moths flew upwind towards both volatiles, with a preference for phenylacetaldehyde. When exposure to either of these volatiles was paired with a feeding stimulus(sucrose), all moths preferred the learnt odour in the preference test. This change in preference was not seen when moths were exposed to the odour without a feeding stimulus. The learnt preference for the odour was reduced when moths were left unfed for 24 h before the preference test.

We tested whether moths could discriminate between flowers that differed in a single volatile component. Moths were trained to feed on flowers that were odour-enhanced using either phenylacetaldehyde or α-pinene. Choice tests were then carried out in an outdoor flight cage, using flowers enhanced with either volatile. Moths showed a significant preference for the flower type on which they were trained. Moths that were conditioned on flowers that were not odour-enhanced showed no preference for either of the odour-enhanced flower types. The results imply that moths may be discriminating among odour profiles of individual flowers from the same species. We discuss this behaviour within the context of nectar foraging in moths and odour signalling by flowering plants.
When Are Stockpiled Products Consumed Faster? A Convenience–Salience Framework of Postpurchase Consumption Incidence and Quantity
Authors: Chandon Pierre , Wansink Brian
Published: November 2003

When people stockpile products, how do they decide when and how much they will consume? To answer this question, the authors develop a framework that shows how the salience and convenience of products influence postpurchase consumption incidence and quantity. Multiple research methods—including scanner data analysis, a field study, and two laboratory studies—show that stockpiling increases product salience and triggers consumption incidence among high-convenience products. However, when the decision is made to consume a product, stockpiling increases the consumption quantity for both high- and low-convenience products. In addition to providing new insights on how consumers make postpurchase consumption decisions, these results have implications for the debate on the value of promotions that induce stockpiling.
Understanding the Role of Preference Revision and Concession in Group Decisions
Authors: Aribarg Anocha , Arora Neeraj , Bodur H. Onur
Published: November 2003

In this article, the authors contend that member influence in a group's decision could be decomposed into two distinct elements of preference revision and concession. Using a hierarchical Bayes model of dyadic decision making, the authors show that the degree of preference revision and concession varies across product attributes, individuals, and product categories. The authors demonstrate that converging preferences affect a member's concession, which in turn affects members’ satisfaction with the joint decision. More important, a member's satisfaction is higher when his or her concession is reciprocated.
Can Repeating a Brand Claim Lead to Memory Confusion? The Effects of Claim Similarity and Concurrent Repetition
Authors: Law Sharmistha
Published: November 2003

Repetition of brand claims is frequently used to promote the learning of brand-related information. Using dual component models of recognition memory, the author examines whether repetition, in the face of repetitions by similar competitors, might paradoxically increase memory confusion. In Experiment 1, the repetition of similar claims of equally familiar competitor brands produced two opposing effects: It increased memory for accurate claim recognition but also elevated brand claim confusion among advertised competitors. The pattern of results was similar when memory was tested a week after the initial exposure. In Experiment 2, in which participants were required to engage in a task designed to promote the “binding” between a brand and its claim, the memory confusion effects of repetition were significantly reduced. Finally, Experiment 3 replicated and generalized these findings by using more realistic stimuli and procedures. Thus, across three studies, the evidence strongly suggests that the confusion-elevating effects of repetition are a result of weak binding between memory for brand and claims.
The Asymmetric Share Effect: An Empirical Generalization on Cross-Price Effects
Authors: Sethuraman Raj , Srinivasan V.
Published: November 2003

Prior empirical literature states that asymmetry in cross-price effect favors the high-share brand. That is, when high-share brands discount, they have a greater impact on low-share brands than the reverse. This conclusion is based on consideration of cross-price elasticities. The authors point out that focusing on cross-price elasticities for assessing asymmetry is inappropriate for determining the incremental profitability from price promotions. Instead, asymmetries should be investigated in absolute cross-price effects, that is, change in market share of a competing brand for a unit price change of the focal brand. The authors theoretically and empirically demonstrate that asymmetry reverses when absolute cross-price effect is considered. That is, the absolute cross-price effect of a price reduction of a low-share brand on the market share or sales of a high-share brand is greater than the reverse. The authors discuss the implications of the findings and future research directions.
The Role of Issue Valence and Issue Capability in Determining Effort Investment
Authors: Mittal Vikas , Ross William T. , Tsiros Michael
Published: November 2003

How decision makers invest their effort among various issues is critical to organizational success ( Ocasio 1997 ). The authors investigate the effects of issue valence and issue capability on how decision makers allocate effort to an issue. They develop hypotheses regarding these constructs and test them in three studies. Results show that in the condition of high capability, decision makers are more likely to invest effort in an issue that is negatively, rather than positively, framed. Conversely, with low capability, they are more likely to invest effort in an issue that is positively, rather than negatively, framed. Results also clarify the variable focus on upside potential and risk taking as two mechanisms that underlie this preference reversal.
The Journal of Marketing Research: Its Initiation, Growth, and Knowledge Dissemination
Authors: Green Paul E. , Johnson Richard M. , Neal William D.
Published: November 2003

The Journal of Marketing Research has now reached almost four decades of growth since its initiation in 1964. It continues to be a rich source of innovative ideas in research methodology and knowledge diffusion for both practitioners and academics. This article pays tribute to the many scholars who have contributed to the Journal of Marketing Research's success and continued service to marketing researchers worldwide. The authors describe the early years of the Journal of Marketing Research and illustrate how it has become the premier journal in marketing research methodology. In so doing, they discuss its important role in the dissemination of knowledge through the Advanced Research Techniques Forum and other special interest marketing groups. The authors also stress the significant role of software development in the implementation of the increasingly complex computations associated with advanced marketing research methods.
Interdependence and Its Consequences in Distributor-Supplier Relationships: A Distributor Perspective through Response Surface Approach
Authors: Kim Stephen Keysuk , Hsieh Ping-Hung
Published: November 2003

Despite its importance for marketing channels research, the effect of interdependence on channel outcome variables remains elusive because of the inconsistent manner in which it is operationalized and the analytical methods used to assess its impact. To address those gaps, the authors first review prior approaches and identify the sources of their limitations. Then, the authors use the response surface approach (RSA) and derive three managerial insights that can be garnered from its use. They apply RSA to industrial distributor-supplier relationships and contrast it with previous methods. The empirical study results suggest that distributors perceive differential effects of supplier dependence and distributor dependence on outcome variables. The authors elaborate on managerial and research implications of the RSA results.
A Bargaining Theory of Distribution Channels
Authors: Iyer Ganesh , Villas-Boas J. Miguel
Published: November 2003

A critical factor in channel relationships between manufacturers and retailers is the relative bargaining power of both parties. In this article, the authors develop a framework to examine bargaining between channel members and demonstrate that the bargaining process actually affects the degree of coordination and that two-part tariffs will not be part of the market contract even in a simple one manufacturer-one retailer channel. To establish the institutional and theoretical bases for these results, the authors relax the conventional assumption that the product being exchanged is completely specifiable in a contract. They show that the institution of bargaining has force, and it affects channel coordination when the complexity of nonspecifiability of the product exchange is present. The authors find that greater retailer power promotes channel coordination. Thus, there are conditions in which the presence of a powerful retailer might actually be beneficial to all channel members. The authors recover the standard double-marginalization take-it-or-leave-it offer outcome as a particular case of the bargaining process. They also examine the implications of relative bargaining powers for whether the product is delivered “early” (i.e., before demand is realized) or “late” (i.e., delivered to the retailer only if there is demand). The authors present the implications for returns policies as well as of renegotiation costs and retail competition.
Prozessstufen übergreifende Synthese eines Qualitätsmodells für Sinteranlagen von Eisenerzen (Synthesis of Plantwide Quality Prediction Systems for Iron Ore Sintering Plants)
Authors: Langer M. , Vogel-Heuser Birgit
Published: November 2003

Bei stark totzeitbehafteten Prozessen, bei denen die Messung der Qualität online nicht möglich ist, bietet die Vorhersage qualitätsbestimmender Zielgrößen eine geeignete Alternative zur effektiven Verbesserung der Prozessführung. Basis einer solchen Vorhersage ist die Prozessstufen übergreifende, ganzheitliche Modellierung von Einfluss nehmenden Wirkzusammenhängen. Am Beispiel einer Sinteranlage für Eisenerze wird über die Anwendung eines Vorgehensmodells für die Synthese eines globalen Qualitätsmodells berichtet.
SmartKom - Multimodale Mensch-Technik-Interaktion (SmartKom – Multimodal Human Computer Interaction)
Authors: Reithinger Norbert , Blocher Anselm
Published: November 2003

Eine der größten Herausforderungen für die Wissensgesellschaft ist derzeit die Schaffung intelligenter Benutzerschnittstellen, die den natürlichen Kommunikationsstil von Computerlaien akzeptieren und so unterstützen, dass eine für den Menschen intuitive und benutzergerechte Mensch-Technik-Interaktion entsteht. Im Leitprojekt SmartKom werden Konzepte für die Entwicklung völlig neuartiger Formen der Mensch-Technik-Interaktion erprobt. Das Ziel von SmartKom ist die Erforschung und Entwicklung einer selbsterklärenden, benutzeradaptiven Schnittstelle für die Interaktion von Mensch und Technik im Dialog. Das Vorhaben wird von der Vorstellung geleitet, die Vorteile sprachlich dialogischer Kommunikation zu verschmelzen mit den Vorteilen graphischer Bedienoberflächen und gestisch Ausdrucks zu verschmelzen. Das Ergebnis ist eine höherwertige Benutzerschnittstelle, die die natürlichen menschlichen Sinne in größerem Umfang als bisher berücksichtigt. SmartKom geht damit einen wichtigen Schritt auf dem Weg zur Entwicklung einer auf den Menschen zugeschnittenen Informationstechnologie.