bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of Life for Children With Functional Abdominal Pain and Their Parents Copmared to Healthy Individuals
Authors:   Pediatric Gastroenterology, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran., Karami Hassan , Lashtoo Aghaee Bahareh ,   Mazandaran University of Medical Sciences, Ramsar, Iran., Yazdani Charati Jamshid ,   Department of Biostatistics, School of Health Sciences, Mazandaran University of Medical Sciences, Sari, Iran., Abedi Alame ,   Mazandaran University of Medical Sciences, Sari, Iran.
Published: November 2022

Objectives: Functional abdominal pain (FAP) is a debilitating disorder that has a high prevalence among children. The goal of this study is to evaluate patients’ and parents’ perceptions of health-related quality of life (QoL) for children with FAP. Methods: Between April 2018 and June 2019, a total of 200 children (including 100 with FAP and 100 healthy individuals) and 200 parents participated in this study. The participants completed a health-related QoL scale (pediatric quality of life inventory) that is scored on a scale from 0 (poor) to 100 (best). Children with FAP and their parents were compared to a control group consisting of healthy children. Results: Children with FAP had lower self-report QoL scores (46.97±17.43) compared to their healthy peers (78.69±13.02) and the difference was significant (P<0.05). Parents of children with FAP reported lower QoL scores compared to parents of the control group (45.56±14.19 vs 75.94±15.06, P<0.05) but it was similar to the scores for their children. Conclusions: The present study demonstrated that children with FAP and their parents experience a poor QoL compared to their healthy peers.
Genealogies of Saints and Strategies of Representation of Clergy in Early Medieval Ireland
Authors:   Lomonosov State University, Zhivlova Nina
Published: November 2022

This article analyzes genealogies as a strategy of representation of clergy in Early Medieval Ireland. The Irish genealogies, especially the genealogies of saints were, as D. Ó Corráin put it, a product of “dynastically-minded clergy”: this hereditary clergy arose from the 7th century on, at latest. Trying to represent the founder saint in the most favourable light and to confirm their own privileges and rights to church property, the compilers of genealogies often used the following devices: (1) suppressing the saint’s foreign origin (St Ailbe and others); (2) portraying the saint as a member of the local ruler’s family or as a relative of an incumbent abbot or an abbatial dynasty (St Rúadán of Lothra); (3) constructing the saint’s maternal genealogy, thereby forging the necessary dynastic connections. All the three strategies were applied in the Irish legend of Saint Gregory the Great: Gregory is presented as a son of an Irishman, who was allegedly a relative of the previous Pope, and his mother was said to be a Pope’s daughter.
The Making of Russian Intellectual Elites in the Age of Enlightenment
Authors:   Herzen State Pedagogical University of Russia, Artemyeva Tatiana
Published: November 2022

During the age of Enlightenment, the processes of national elites' formation in Western Europe somewhat differed from country to country. While in Britain, especially in Scotland, intellectuals constituted a fairly homogeneous group of literati, which included university professors, educated priests, civil servants, and enlightened nobles, in France the ideological attitudes might have been shared by clerics, university professors, and "free thinkers," primarily "encyclopedists." In Russia, the situation was peculiar. At the beginning of the 18th century, the structure of the intellectual elite changed. The clerical Orthodox elite became segregated due to the restrictive decrees of Peter the Great. After the founding of St. Petersburg Academy of Sciences in 1724 and Moscow University in 1755, an academic elite emerged, and a noble intellectual elite took shape. While European intellectual elites developed within a single paradigm and built their internal oppositions most often along the lines of ideological irreconcilability (for example clericals and encyclopedists in France), Russian intellectual elites were barely connected to each other. They were formed in the context of different educational trajectories, shared no common intellectual institutions or communication platforms (it is not by chance that Russian universities had no theology departments: theological education existed in the framework of separate church schools), and they appealed to different authorities. All this contributed to the parallel existence of very different intellectual models and philosophical systems. The situation became even more complex in the 19th century with the emergence of the intelligentsia as a social group in its own right.
Métodos e Técnicas Não Farmacológicos no Tratamento da Dor Oncológica: Revisão Sistemática da Literatura
Authors: Nascimento Natali dos Santos , Santos Amanda Tinôco Neto , Alves Priscila Godoy Januário Martins
Published: November 2022

Introdução: A dor é uma sensação desagradável e responsável por diversos prejuízos na vida dos pacientes oncológicos. Esse sintoma pode estar relacionado a diversos fatores, ter múltiplos níveis de intensidade e tempo de aparecimento, podendo ser associada à disseminação invasiva de células cancerosas no corpo ou em decorrência do tratamento antineoplásico. Objetivo: Verificar quais são as técnicas e os métodos não farmacológicos utilizados no tratamento da dor do câncer, assim como descrever sobre sua eficácia terapêutica. Método: Revisão sistemática da literatura, registrada com o número CRD42021244286 no PROSPERO. Os artigos científicos sobre a temática foram pesquisados nas bases de dados eletrônicas: LILACS, PubMed, PEDro, Cochrane/CENTRAL, em português, inglês e espanhol, de 2010 a 2020, de acordo os critérios de inclusão; ensaios clínicos randomizados controlados, com amostra composta por adultos com mais de 18 anos, de ambos os sexos, com dor relacionada ao câncer, que utilizaram métodos e técnicas não farmacológicas para tratar o quadro álgico. Resultados: Foram incluídos para análise 12 artigos com amostra total de 885 pacientes submetidos a protocolos de técnicas não farmacológicas com: acupuntura, acupuntura auricular, acupressão, eletroterapia, yoga, exercícios de terapia manual, reflexologia, massagem, programa de educação para gerenciamento da dor. Todos os artigos analisados apresentaram bons resultados no tratamento da dor do câncer. Conclusão: As modalidades de terapias complementares, educação em saúde e a eletroestimulação podem contribuir na redução do quadro álgico; no entanto, programas de exercícios só possibilitam melhorias durante o período do tratamento.
Opiniones e interés en ciencia y tecnología de mujeres y hombres adolescentes ecuatorianos
Authors: Camacho M. Alejandra , Salgado M. Jorge , Montúfar Rommel , Moreta-Herrera Rodrigo , Rivadeneira Gabriel , Merlyn Marie-France
Published: November 2022

Este trabajo tuvo como objetivo explorar los intereses y opiniones sobre ciencia y tecnología y la influencia del género en estudiantes ecuatorianos. Para ello, se aplicó el cuestionario Relevancia de la Educación Científica (ROSE, por sus siglas en inglés) a una muestra de 1054 estudiantes de entre 16 y 18 años de segundo y tercer años de bachillerato general unificado (BGU). Los resultados muestran opiniones favorables hacia la ciencia y la tecnología, pero solo un interés moderado en los adolescentes, quienes, en general, prefieren no recibir más clases de esas asignaturas. Por otro lado, los estudiantes son positivos sobre el impacto que tienen la ciencia y la tecnología en la sociedad. Finalmente, se encontraron variaciones en la distribución de los temas de interés según el género. Se discuten las implicaciones de estos resultados, la situación actual del currículo ecuatoriano de ciencias y la investigación futura.
Long-term Maintenance of Retest Learning in Young Old and Oldest Old Adults
Authors: Yang Lixia , Krampe Ralf T.
Published: November 2022

This study examined the maintenance of retest learning benefi ts in young old and oldest old adults over an 8-month period in 3 cognitive abilities: reasoning, perceptual-motor speed, and visual attention. Twenty-four young old (aged 70 – 79 years, M = 74.2) and 23 oldest old adults (aged 80 – 90 years, M = 83.6) who participated in a previously published study (Yang, L., Krampe, R. T., & Baltes, P. B. [2006]. Basic forms of cognitive plasticity extended into the oldest-old: Retest learning, age, and cognitive functioning. Psychology and Aging, 21, 372 – 378) returned after an 8-month delay to complete 2 follow-up retest sessions. The results demonstrated that both young old and oldest old groups maintained about 50% of the original retest learning benefi ts. This extends the earlier fi ndings of substantial long-term cognitive training maintenance in young old adults to a context of retest learning with oldest old adults, and thus portrays a positive message for cognitive plasticity of the oldest old 
Research on improving the basis weight measurement accuracy of tissue paper based on PSO-BP neural network
Authors: HU LIANHUA , FENG YUXIU , MA JIN
Published: November 2022

The near-infrared (NIR) sensor can be used for measuring the basis weight and moisture of tissue paper, but the measurement accuracy is not ideal for this paper grade. The weight range of the tissue is 10~30 g/m2, indicating that it is a low gram weight paper. The temperature and humidity of the production environment significantly impact an NIR sensor. This paper focuses on improving the measurement accuracy of tissue paper basis weight. In order to reduce the influences of temperature and humidity, a mathematical model based on a particle swarm optimization back propagation (PSO-BP) neural network is proposed. In comparison with multiple linear regression measurement models, the basis weight measurement error with the PSO-BP model is within ± 0.5 g/m2. This model can effectively improve the measurement accuracy and has a good effect on overcoming the basis weight nonlinear effect caused by the changes in ambient temperature and humidity.
From School Library Media Specialist to Academic Librarian: Finding and Landing the Job for You!
Authors: Dye-Reeves Amy
Published: November 2022

The following article denotes a library media specialist’s journey to obtain an academic librarianship position through the lens of imposter syndrome. The information contained in the article is presented through a singular lens and provides insight to help inspire library media specialists to apply and obtain future academic librarian positions.
Getting There is the Journey: Obtaining International Grant Funding for a Professional Experience Abroad
Authors: Webb Katy
Published: November 2022

This column gives practical advice to early-career librarians in search of an international travel grant to gain professional experience abroad. The author completed a Fulbright Specialist grant in 2019-2022 and offers information to disambiguate the process of obtaining one such grant, including information about identifying grants, applying, locating a host, and more.
Evaluasi Teknis dan Biaya pada Sistem Penyaliran Tambang di Pit 4 Edward PT Caritas Energi Indonesia Sarolangun Jambi
Authors: Annisa Nur , Franto Franto , Andini Delita Ega
Published: November 2022

This research was conducted to redesign the dimensions of the temporary sump to accommodate the total volume of incoming water so as to minimize the occurrence of puddles around the mining area. The method used is a quantitative method by analyzing daily rainfall data for 10 years (2011-2020) using the Gumbell distribution. Actual data in the form of field rainfall intensity, sump water level rise, dimensions and actual discharge of the channel as well as the length and diameter of the pipe. Based on the 5-year return period, the total incoming discharge is 27,043.160 m3/day and based on the maximum rainfall of 30,693.351 m3/day after pumping 607.71 m3/hour for 7 hours, resulting in a residual discharge of 22,789.190 m3/day for 37.5 hours (PUH 5 years) and 26,439.387 m3/day for 43.5 hours (maximum CH). The actual dimensions of all four of Edward's Pit 4 channels are already larger than theoretical. The pump cost which is planned to operate for 7 hours is Rp 408,107.14/day while the actual pump operates 4 hours with additional maintenance costs of Rp 174,811.20/day or ± 42% of the planned cost. Making the actual temporary sump is Rp 73,598,773.90 with an additional cost of making the recommended sump of Rp 62,874,123.60 or ± 85% of the actual cost with a total cost of Rp 272,744,273.
Morphological Fantasies: Posthuman Embodiment in Tian Xiaolei’s Video Art
Authors: Yang Xiaoli
Published: November 2022

This article explores the issue of posthuman embodiment envisioned in contemporary Chinese artist Tian Xiaolei’s (田晓磊) two representative videos: The Creation (Chuangzao “创造,” 2015) and Greatness (Weida “伟大,” 2017). Perceived and envisaged from an erotic perspective, The Creation reveals humans’ unrestrainable lust and desires for fusing with technology, while Greatness, by taking a different trajectory of remaking a Buddhist mandala, provides us with a set of religious symbolism and reconstructs the spiritual order of a posthuman future, thereby invoking an intriguing affinity between posthumanism and Buddhism with respect to a renewed conceptualization of the human. It argues that both works invite us to experience and ponder on, aesthetically and conceptually, the kaleidoscopic morphology of human corporeality in the posthuman condition.
Buran, S. (Ed.). (2020). Edebiyatta posthümanizm. TPLondon.
Authors: Zampaki Nikoleta
Published: November 2022

The edition entitled Edebiyatta Posthümanizm [Posthumanism in Literature] is the first edition in the Turkish language which introduces the narrative of posthumanism in Anglo-American Literature and Culture. This edition is the first book of the Posthumanism Series by TPLondon, edited by Sümeyra Buran, that examines how posthumanism is conceptualized in literary writing by studying the western traditional binaries, e.g. human and nature, human and non-humans, and so forth, that have nurtured the ideology and mentality of western societies for centuries. This edition also examines the contribution of literature in presenting alternative ideas and thoughts by laying the ground of Posthumanities in Turkey by opening new doors for the readers to understand the changing status of man and the nature of the relationship (e.g. hybrid, parasitic, etc.) between the human and more-than-human world.
MULTILEVEL LATENT PROFILE ANALYSIS OF ESTONIAN SECONDARY SCHOOL STUDENTS' CAREER EXPECTATIONS WITH SCIENCE ACHIEVEMENT AND GENDER AS COVARIATES
Authors: Jiang Tao , Chen Ji-gen , Xu Ping-chuan , Zeng Ping-fei
Published: November 2022

Although much research has explored the personal, family, school, and social influences on adolescents' career expectations, little is known about the types of family-related career expectations of students and career expectation contexts in school. Using PISA 2018 test data, a multi-level latent profile analysis was conducted with indicators of parents' occupational status and children's career expectations. This research found that family-related career expectations of Estonian secondary school students can be divided into three types: enterprising, resilient, and disengaged. At the organizational level, contexts for career expectations in schools can be classified as enterprising, enterprising and resilient composite, and disengaged and resilient composite types. The research also found that science achievement and gender predicted latent profile memberships at the individual level. It is proposed that to value the science curriculum and its teaching is to invest in future human resources. It is suggested that families and schools should pay attention to stimulating male students' career aspirations. The career expectation types of secondary school students within and between schools are of great significance to the construction of national human resources, the development of schools, and the research of families.
Keywords: career expectation types, multilevel latent profile analysis, PISA 2018 datasets, variations between schools, science achievement
TEACHING OF CRITICAL THINKING SKILLS BY SCIENCE TEACHERS IN JAPANESE PRIMARY SCHOOLS
Authors: Kinoshita Hiroyoshi
Published: November 2022

The importance of critical thinking in science education is widely recognized. However, little research has been conducted on the teaching of critical thinking by teachers. If actual teaching conditions of teachers in the classroom are clarified, effective teaching methods for developing critical thinking in students could be developed. This study administered a questionnaire survey to ascertain how science teachers teach critical thinking in Japanese primary schools. The study population consisted of 291 Japanese primary school teachers with teaching careers spanning 1–38 years. The survey revealed the following. (1) Teachers taught students the importance of conducting experiments by themselves to obtain results. However, teachers did not sufficiently teach students the need to conduct multiple experiments before reaching a conclusion, improve data reliability before making decisions, or examine their conclusions carefully given incomplete data. (2) Compared to teachers with shorter teaching careers, teachers with longer careers taught critical thinking more effectively, particularly in terms of emphasizing positivity and maintaining a healthy skepticism. (3) Teachers who taught emphasized positivity and encouraged multifaceted thinking were more likely to teach about emphasized evidence. The corresponding causal relationship analysis suggests that teaching that emphasizes positivity and encourages multifaceted thinking is key to promoting evidence-oriented instruction.
Keywords: science learning, critical thinking skills, in-service teachers, teaching skills, teachers' training
Desarrollo sexual en la infancia: emociones y comportamiento
Authors: Sarmiento Sarmiento Sandra Azucena , Estévez Montalvo Luis Edmundo , Polo Martínez Eulalia Maribel
Published: November 2022

Introducción. La infancia es una etapa de la vida que se caracteriza por la observación, la curiosidad y el descubrimiento, mediante la experimentación y el juego los niños se conocen a sí mismos y a su entorno. En la etapa del desarrollo sexual, los niños toman conciencia del sexo al que pertenecen imitando roles de las personas que le rodean, lo cual marca el comportamiento y la adaptación al medio. Objetivo. Determinar los factores emocionales y de comportamiento que intervienen en el desarrollo sexual infantil, diferenciando la conducta normativa y patológica. Metodología. Se realizó una revisión sistemática usando prisma, luego de la depuración se obtienen 19 artículos científicos de los últimos 10 años obtenidas de bases de datos científicas: Scopus, Web of Science, PubMed, Taylor & Francis y Google Académico. Resultados. Se evidenció que existen dos tipos de comportamiento sexual, el normativo, basado en la autoexploración, imitación, la expresión de afecto hacia sí mismo y los demás y el patológico, en el que las conductas y las emociones de lo normativo se expresan de manera más sobredimensionada y como un patrón frecuente y se lo relaciona con frecuencia con el abuso sexual. Conclusión. Los factores emocionales como la afectividad, la autoestima y los de comportamiento como la curiosidad y autoexploración representan los componentes centrales de la conducta normativa, mientras que en la conducta patológica encontramos emociones como la tristeza, angustia, temor, agresividad y manipulación excesiva de sus genitales. Para un desarrollo sexual saludable, es indispensable los niños tengan orientación y reciban información adecuada a su edad para generar seguridad y confianza.
Insulin Resistance in Chronic Kidney Disease Patients Without Diabetes
Authors: Das Soma , Barua Prasun , Alam Abu Mansur Md Didarul , Karmakar Pijush , Haque Mahmudul
Published: November 2022

Background: Cardiovascular disease is the leading cause of morbidity and mortality in patients of Chronic Kidney Disease (CKD). According to recent studies, insulin resistance and compensatory hyperinsulinemia may have some important roles in cardio-renovascular complications of these patients. So, the aim of this study was to evaluate the insulin resistance status in nondiabetic CKD patients and whether it correlates with glomerular function. Materials and methods: This crosssectional comparative study was carried out in the Department of Biochemistry, Chattogram Medical College from January to December, 2016. A total of 130 subjects of 30- 60 years were included by nonprobability consecutive sampling. Of them, 80 were nondiabetic CKD patients of stages III-V and 50 were healthy controls. Fasting plasma glucose, creatinine and insulin concentrations were measured using automated analyzers. Insulin resistance index was determined by Homeostatic Model Assessment Insulin Resistance (HOMA-IR) whereas eGFR was calculated by MDRD formula. Results: The nondiabetic CKD patients had significantly higher mean fasting plasma insulin (18.08 mIU/L) compared to controls (9.43 mIU/L). They also showed significantly higher mean HOMA-IR values (4.37) relative to healthy individuals (2.23). Overall, insulin resistance was 66% in nondiabetic CKD patients vs. 18% in controls. There was significant association of insulin resistance with CKD. But, HOMA-IR did not seem to correlate with CKD stages or eGFR. Conclusion: In conclusion, this study revealed significant association between insulin resistance and nondiabetic CKD, even though substantial correlation between insulin resistance and glomerular filtration rate was absent.

JCMCTA 2019 ; 30 (1) : 51-55
Rehabilitation Approaches of a Bangladeshi Boy With Ataxia Telangectasia: A Case Report
Authors: Newaz Fatema , Parvez Md Farhad , Islam Hasibul , Uddin Taslim , Rahman Md Safiur , Khandakar Md Nuruzzaman
Published: November 2022

Ataxia-Telangiectasia (AT) is a rare form of neurodegenerative disorder of hereditary origin. In Bangladesh we don’t have any epidemiological study. Till today there is no gold standard of the diagnosis, further to its wide clinical heterogeneity, it often leads physicians to an incorrect or missed diagnosis. So is the importance of the insight into this disease. We report a 10 years old male child who presented with history of difficulty in posture and walking associated with frequent fever, delayed slurred speech and abnormal eye movements. Physical examination revealed delayed milestones of development involving neck control, sitting, walking, unsteady supported swaying gait and speech language dysfunctions. MRI of brain showed cerebellar atrophy and a raised serum Alfafeto protein level. The child was diagnosed as a case of AT and was presented in a clinical meeting at Bangabandhu Sheikh Mujib Medical University for discussions and further managements including medical rehab. We offered him a course of combined rehabilitation therapy program and discharged home.

JCMCTA 2019 ; 30 (1) : 64-67
PERBANDINGAN MODEL DISCOVERY LEARNING DAN EKSPOSITORI TERHADAP HASIL BELAJAR SISWA MATERI BANGUN RUANG SISI DATAR
Authors: Martucilia Wenny , Agustinsa Ringki , Utari Tria
Published: November 2022

Penelitian ini bertujuan untuk mengetahui perbandingan model pembelajaran Discovery Learning dan metode Ekspositori terhadap hasil belajar matematika siswa kelas VIII SMP Negeri 3 Kota Bengkulu pada materi bangun ruang sisi datar. Jenis penelitian yang dilakukan pada penelitian ini yaitu penelitian eksperimen semu (quasi eksperiment research) dengan desain the nonequivalent pretest-posttest control group design. Populasi dalam penelitian ini adalah seluruh siswa SMP Negeri 3 Kota Bengkulu dengan dua kelas sampel yang dipilih melalui purposive sampling yaitu kelas VIII 4 (kelas eksperimen) dan VIII 5 (kelas kontrol) yang berjumlah masing-masing 30 orang. Pengumpulan data dilakukan dengan metode tes hasil belajar. Nilai rata-rata posttest kelas eksperimen sebesar 54,4 dan nilai rata-rata posttest kelas kontrol sebesar 34,0. Hasil dari pengujian hipotesis diperoleh nilai  sehingga dapat disimpulkan bahwa hasil belajar matematika siswa kelas VIII SMP Negeri 3 Kota Bengkulu pada materi bangun ruang sisi datar dengan model Discovery Learning lebih baik dari hasil belajar matematika metode Ekspositori.
DIAGNOSIS KESALAHAN PESERTA DIDIK DALAM MENYELESAIKAN SOAL URAIAN ARITMETIKA SOSIAL
Authors: Epran Epran , Siagian Teddy Alfra , Utari Tria , Agustinsa Ringki , Irsal Nur Aliyyah
Published: November 2022

Penelitian ini bertujuan untuk mendeskripsikan jenis-jenis kesalahan serta faktor-faktor penyebab yang dilakukan peserta didik dalam menyelesaikan soal uraian aritmetika sosial. Jenis penelitian ini adalah kualitatif dengan pendekatan deskriptif. Pengumpulan data dilakukan menggunakan tes diagnostik dan wawancara diagnostik. Subjek penelitian ini ialah kelas VII-B SMP Negeri 11 Kota Bengkulu yang berjumlah 29 peserta didik. Hasil penelitian menunjukkan bahwa: 1) jenis-jenis kesalahan yang dilakukan peserta didik berupa kesalahan konsep dengan rata-rata 22,7%, kesalahan interpretasi bahasa dengan rata-rata 29,3%, kesalahan prosedur dengan rata-rata 69%, dan kesalahan berhitung dengan rata-rata 63%, 2) faktor penyebab yang dilakukan peserta didik sehingga melakukan kesalahan pada saat mengerjakan soal tes yang diberikan yaitu, faktor internal sebesar 60% yakni intelegensi, minat, motivasi serta kesehatan, serta faktor eksternal 48% yakni, lingkungan, sarana sekolah, dan keluarga. Guru maupun siswa harus dapat berkolaborasi dalam proses pembelajaran untuk mencapai tujuan pembelajaran.
Study Internet of Things (IoT) untuk Autonomous Kelembaban Tanah pada Tanaman dengan NodeMCU V3 ESP8266
Authors: Lazim Farihin , Hidayat Imam
Published: November 2022

Budidaya tanaman saat ini dalam kondisi keterbatasan waktu dan kesempatan dalam melakukan perawatan dibutuhkan sebuah inovasi teknologi untuk tetap bisa mempunyai tanaman tetap tumbuh kembang dengan baik, tanpa harus menyiramnya secara manual. Maka diperlukan sebuah inovasi Internet of Things (IoT) untuk membantu pekerjaan manusia dalam hal monitoring dan otomatisasi irigasi berdasarkan data hasil pengukuran suhu, kelembaban tanah dan kelembaban udara sekitar tanaman secara real-time. Tiga buah sensor digunakan dalam pembuatan alat ini, yaitu sensor kelembaban tanah CSMS, sensor suhu DS18820, dan sensor DHT11. NodeMCU V3 ESP8266 yang menjadi mikrokontroller sekaligus konfigurasi dan koneksi terhadap aplikasi Blynk dalam proses IoT monitoring dan controlling secara jarak jauh. Pada pengujian functional suitabillity, diketahui bahwa dengan fitur yang diuji pada Internet of things (IoT) untuk pengaturan kelembaban tanah pada tanaman dengan NodeMCU V3 ESP8266, akses atau instruksi dapat bekerja sesuai dengan requirement awal. Hasil penilaian perpektif functional suitability menunjukkan 100% sistem berfungsi dengan baik. Hasil dari Penelitian dapat dikembangkan lebih lanjut pada skala yang lebih besar dan memiliki potensi tepat guna sebagai tolok ukur pada lembaga penelitian dan pengembangan yang berfokus pada tanaman tertentu.
Incomplete Situs Inversus Associated with Common Mesentery and Splenic Duplicity: About A Case and Literature Review
Authors: B Nonoa , FD Le-Mbaye , SR Sade , M Chamutu , PD Adjakidje , FD Le-Mbaye , F Rimtebaye , LA Azakpa , B Seko , MT Akpoto , G Konigui , PC Miyanhouande , RA Gayito Adagba
Published: November 2022

Situs inversus is a rare congenital malformation characterized by the inverted position of the thoracic and abdominal organs relative to the sagittal plane. It can be complete or incomplete. We report an incomplete case of situs inversus associated with a common mesentery and splenic duplicity, revealed by acute generalized peritonitis by ileal perforation of typhic origin.
Online Booking Application for Long-Distance Train Ticket Adapted to the Covid-19 Protocol
Authors: Relawanti Diah Asih , Ujung Yopi Mahangga , Pradania Rossy Yanuar , Nugroho Andi , Kodar Achmad
Published: November 2022

Train is favorite transportation in Indonesia. The increase in the number of passengers from year to year is proof that rail transportation supports community mobility. Therefore, services are needed to accommodate the needs of the community in ordering train tickets. Currently, the train ticket booking system can be done offline or online. Especially for the online train ticket booking system, there are still some obstacles i.e., during the Covid-19 pandemic, a train ticket booking information system is also needed which must be adjusted to health protocols to minimize the spread of Covid-19 during travel by train, starting from the ticket booking process. The system development methodology used is Scrum, this methodology is a framework that applies the stages of planning, analysis, design and implementation to build or develop software where work is divided into time frames called sprints. The long-distance train ticket booking application has been able to minimize the accumulation of passengers in exchanging tickets at the train station platform.
Analysis of UI Convenience Influence of Marketplace MobileApplication towards Consumers’ Online Buying Interset
Authors: Af’idati Layla Nurul , Richard Richard , Pradipta Indry A , Retnoningsih Endang
Published: November 2022

The purpose of this study was to conduct an analysis to determine whether there was an effect or not of the interface convenience (user interface) of the marketplace mobile application on consumers’ online buying interest. The design method applied was the Technology Acceptance Model (TAM) which referred to the individual acceptance behavior of information technology systems. The analysis was carried out using the Structural Equation Modeling method with the Partial Least Square (SEM-PLS) model. The results achieved from this study prove that the interface convenience of the marketplace mobile application had a significant and positive effect on online buying interest in both male and female consumers. Based on the results of this study, it can be concluded that the convenience felt by consumers both male and female consumers when viewing the user interface of marketplace mobile applications will have an impact on online buying interest.
Linking Pathophysiology to Clinical Options in Psoriasis: New Insights into Interleukin-23
Authors: Hesp Blair
Published: November 2022

Prof Costanzo welcomed attendees to the symposium and outlined the agenda before explaining the autoimmune pathophysiology that underlies psoriasis. Dr Caprioli discussed the role of the T helper (Th)17 cell lineage and its accompanying cytokines in autoimmune diseases. Prof Paul discussed the latest clinical trial data for therapies targeting the interleukin (IL)-17/IL-23 axis in patients with psoriasis, and how this is changing the treatment landscape. The symposium was followed by a question and answer session.
The Skin Microbiome in Patients with Acne Vulgaris
Authors: Moloney Juliane
Published: November 2022

Similar to some other tissues such as the gut, the skin is colonised by a dense community of commensal microorganisms. Maintaining the balance of this diverse flora may be important for healthy skin. Changes in the composition of cutaneous microbial communities have been linked to several chronic inflammatory skin diseases, including atopic dermatitis, psoriasis, and acne. Acne is a chronic inflammatory disease that affects the pilosebaceous follicle. The association between Propionibacterium acnes and acne vulgaris has been well established, but very few studies have investigated the total facial skin microbiota of acneaffected patients. Three-dimensional topographic analyses and microbiome profiling have, however, revealed differences in microbiome composition between healthy skin and acne lesions, as well as natural differences in microbial colonisation between the sebaceous gland and surface skin.1 Furthermore, bacterial communities of the skin are involved in immune homeostasis and inflammatory responses important in the development of all acne lesions.2 This improved understanding of the interactions between skin microbiota and the innate immune response in acne may provide a platform to design efficacious treatment strategies, specifically concerning the role of dermocosmetics to protect the skin microbiome.
Biologic Therapies: Clinical Practice in a Changing Environment
Authors: Smithers Lucy
Published: November 2022

Biological therapies have been in use for treating psoriasis for a decade now, and they have greatly improved disease outcomes and quality of life for patients. The success of biologic therapies has been assisted by the development of evidence-based guidelines for their use, and the achievement of consensus on treatment goals. The future of biologic therapies for psoriasis will be different from the past decade, with new anti-inflammatory targets for antibodies being developed and the increasing availability of biosimilar versions of existing antibodies as patents expire. While reduced costs may exert a pressure to switch to biosimilars, it is important to appreciate that they may not be identical in efficacy. Biologics are large, complex molecules, produced by biosynthetic means, which inherently lead to variations in structure. These slight variations in the manufacture of biologics can lead to clinically relevant changes in efficacy. As more biosimilars become available, their interchangeability becomes an important challenge for use in clinical practice, both between a biosimilar and the originator, and between two different biosimilars. Thus, robust trials of interchangeability are urgently needed. Caution in the use of an increased range of biosimilars will also be needed as switching between drugs can potentially increase immunogenicity and neutralise the drug’s efficacy.

The introduction of biologic therapies has been a great achievement in the treatment of psoriasis. The new biologics and biosimilars coming into practice will need to be used with care, for which robust data on safety, efficacy, and interchangeability will be needed, as well as continuing pharmacovigilance.
Significance of Diet and Oral Supplementation in Acne Vulgaris
Authors: Szmurło Agnieszka , Kucharska Alicja
Published: November 2022

Acne vulgaris is one of the most common skin diseases in the world. There are many factors involved in its pathogenesis. The dermatosis is characterised by seborrhoea and the formation of comedones, pustules, and papules and is very unpleasant for patients. Recent data have shown that there may be a connection between acne, diet, and dietary supplements. Researchers have found that milk and dairy products, high glycaemic load, and a diet low in omega-3 fatty acids can aggravate acne. On the other hand, there is also a hypothesis that oral supplementation can be beneficial. Supplements cited as beneficial are products containing omega-3 fatty acids, antioxidants, and probiotics. However, there are still many inaccuracies in this area of dermatology and further research is needed before any recommendations can be made.
Mind–Body Integrative Treatment of Psychodermatoses
Authors: Doglia Azambuja Roberto
Published: November 2022

The mind–skin interaction has been progressively clarified by recent research that has focussed on psychoneuroimmunology. This article focusses on brain–cell communication by means of chemical messengers and the changes in the skin they provoke under stress, providing an origin to dermatoses linked to the mind, called psychodermatoses. The author refers to three types of psychodermatoses: those caused by prior psychiatric disturbances, those that cause psychologic disturbances by their aspect, and those that are influenced by emotional states. This article highlights the four simple and natural mind–body anti-stress techniques of posture, diaphragmatic breathing, muscle relaxation, and meditation that every doctor can teach to patients, which will enable them to face stressful situations and therefore protect themselves against the negative psychological effects of stress. Several therapeutic behaviours in the doctor–patient relationship are recommended to build a patient’s trust in their doctor and to encourage the patient to play an important part in their treatment process. It is emphasised that the treatment of psychodermatoses needs to be co-operative, integrating specialists in dermatology, psychiatry, and psychology. Dermatologists take care of the skin alterations, while psychiatrists are involved with the associated mental disturbances and are able to prescribe a large range of psychopharmaceuticals to treat anxiety, depression, post-traumatic stress disorder, and compulsive states. Psychotherapists try to correct erroneous behaviours and false feelings, employing cognitive-behavioural therapy, analytic and reprogramming techniques, and also hypnosis, in order to rid patients of psycho-emotional perturbations and facilitate successful outcomes in the skin.
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children: A Literature Review of Current Treatments
Authors: Del Pozzo-Magaña Blanca R. , Lazo-Langner Alejandro
Published: November 2022

Stevens-Johnson syndrome and toxic epidermal necrolysis are among the most concerning drug reactions affecting adults and children. Although the overall mortality has reduced substantially after the introduction of several strategies, such as prompt withdrawal of the causal drug and management of the patients in an intensive care or burn unit, these conditions continue to be associated with severe complications and a mortality rate of 1–4%. Currently, several treatment options including systemic corticosteroids, intravenous immunoglobulins, cyclosporine, tumour necrosis factor-α inhibitors, and plasmapheresis among others, have shown inconclusive benefits regarding their efficacy and safety in patients with these conditions. This review analyses the most recent literature regarding treatment options for paediatric patients with Stevens-Johnson syndrome and toxic epidermal necrolysis.
Paste Containing 1.5 μm Ag Particles with Enhanced Surface Area: Ultrafast Thermo-Compression Sinter-Bonding and Annealing Effects
Authors: Kim Yeongjung , Han Byeong Jo , Lee Jong-Hyun
Published: November 2022

To rapidly sinter a bondline and obtain mechanical stability at high temperature and high thermal conductivity, 1.5 μm Ag particles with enhanced surface area were synthesized by a wet-chemical method, and a sinter-bonding paste containing these Ag particles was obtained. Some particles were present in the form of agglomerates of spike stems and short-branch dendrites, while others existed as spheres with rough nodule surfaces or relatively smooth surfaces. To determine an effective sinter-bonding process, a significantly short thermo-compression bonding (10 s) under 5 MPa in air and subsequent annealing in nitrogen were performed. The thermo-compression bonding at 250 oC resulted in a low shear strength of 8.15 MPa in the formed bondline. Although the annealing at 250 oC increased its strength, it did not reach 20 MPa, which is required for practical applications. Interestingly, the 10 s bonding at 300 oC exhibited sufficient shear strength of 21.96 MPa, and when annealed for 30 min at 300 oC, the excellent strength of 37.75 MPa was obtained. The bondline porosity of 12.16% immediately after the thermo-compression bonding, decreased to 9.13% after annealing for 30 min. The densification in bondline by the annealing also induced a change in the fracture path as well as enhancement in the shear strength. Thus, the suggested subsequent annealing is an effective method for sinter-bonding, similar to the pressureless sinter-bonding process. Consequently, the synthesized Ag particles exhibited superior sintering properties and the suggested combination process shows potential for tremendously improving chip sinter-bonding productivity.
Medication induced sleepwalking
Authors: Sychev D. A. , Ostroumova O. D. , Cherniaeva M. S. , Ismailova S. V. , Shakhgildian N. V.
Published: November 2022

Sleepwalking (somnambulism, noctambulism) is a form of parasomnia associated with non-REM sleep, which is characterized by the presence of recurring episodes of sleep-congruent simple or complex behavioral manifestations upon awakening from non-REM sleep. Causes of sleepwalking include increased excitability during non-REM sleep, sleep deprivation, a decrease in the severity of inhibitory processes against the background of defects in GABAergic inhibitory influences and suppression of cholinergic neuronal activation. In adulthood, somnambulism is malignant in nature, and can lead to various adverse consequences. Some of the drugs can cause the development of sleepwalking, in addition, in some cases, the drugs that are used to treat this condition can themselves provoke sleepwalking, such conditions are called drug-induced (DI) sleepwalking. To date, about 30 drugs have been verified, the use of which is associated with the occurrence of sleepwalking, primarily benzodiazepine receptor agonists, atypical antipsychotics, antidepressants and other serotonergic drugs, as well as β-blockers. Risk factors for the development of DI sleepwalking include a history of sleepwalking episodes, the combined use of 2 or more drugs that can provoke its development, and the combined use of potential inducer drugs with alcohol. Treatment includes withdrawal of the inducer drug, cognitive behavioral therapy, and psychopharmacotherapy.
Epilepsy associated with pituitary neuroendocrine tumors: Current status of problem and interdisciplinary approach
Authors: Vasilenko A. V. , Chudievich S. N. , Ulitin A. Yu. , Makhortova S. A. , Rasulov Z. M. , Bubnova P. D. , Sokolov I. A. , Bulaeva M. A. , Lavrovskiy P. V. , Vershinin A. E. , Likhachev M. A.
Published: November 2022

This literature review is devoted to the problem of epilepsy caused by pituitary neuroendocrine tumors: their detailed classification with the latest recommendations of the World Health Organization 2022, clinical picture of each variant of pituitary neuroendocrine tumor in a complex multidisciplinary approach are considered. The main feature of the review is a detailed consideration of the epilepsy associated with this condition, which is considered to be a rather rare manifestation of the disease (incidence in patients is 0.5 %), due to which very few cases of epilepsy in patients with pituitary adenoma have been described in the literature. Our work has analyzed the fundamental works of domestic scientists in this field, as well as current information from foreign sources and most of the available clinical cases of epilepsy in this group of patients, revealing in detail the pathogenesis of epilepsy at all levels, including molecular changes. Modern techniques for the treatment approach in this group of patients are also described, the effectiveness of drug and surgical therapy is analyzed according to the criteria of the frequency of long-term persistent remission and recurrence, side effects of drugs and complications of transsphenoidal tumor resection are reviewed, including in terms of possible epilepsy; conclusions about the most rational and effective approach to treatment of various types of hypophysial neuroendocrine tumors are drawn.
A systematic review and meta-analysis on different stem fixation methods of radial head prostheses during long-term follow-up
Authors: Yang Guang , Li Shangzhe , Zhang Hailong , Lu Yi
Published: November 2022

Background: Radial head arthroplasty (RHA) is typically performed for non-reconstructible radial head fractures with or without valgus stability. The fixation methods can be divided into cemented rigid fixation, such as screw fixation, and uncemented micromovement fixation, including smooth stem, press-fit, expanded device, in-growth stem, and grit-blasted stem fixations. Different fixation methods may impact long-term clinical outcomes and cause complications. This study aimed to compare the long-term follow-up outcomes of cemented and uncemented radial head prostheses.

Methods: A computerized literature search was performed in the PubMed/MEDLINE, Embase, Cochrane Library, and Web of Science databases for studies on radial head prostheses, replacement, and arthroplasty published from inception to April 2022. The prostheses fixation method was divided into cemented and uncemented fixation groups. The outcomes of interest included the participant characteristics, prostheses types, clinical outcomes, reoperation rates, and complication rates during long-term follow-up.

Results: A total of 57 studies involving 2050 patients who underwent RHA were included in our analysis. Cemented fixation was used in 23 of these studies, uncemented fixation in 35 studies, and both cemented and uncemented fixations in one study. Both fixation groups showed significantly improved clinical outcomes after treatment. In particular, both the reoperation and complication rates were lower in the uncemented fixation group (12% and 22%, respectively) than that in the cemented fixation group (20% and 29%, respectively). Among the studies, uncemented monopolar fixation had the lowest reoperation rate (14%), while cemented monopolar fixation had the highest reoperation rate (36%). Regarding complication rates, uncemented bipolar fixation yielded the lowest rate (12%), while cemented bipolar fixation yielded the highest rate (34%). The range of motion and clinical outcome scores were good in both groups.

Conclusion: Uncemented radial head prostheses had lower reoperation and complication rates than cemented prostheses. In particular, uncemented monopolar prostheses may yield the lowest reoperation rate, while uncemented bipolar prostheses may yield the lowest overall complication rate.
Vesicle-based cell-free synthesis of short and long unspecific peroxygenases
Authors: Walter Ruben Magnus , Zemella Anne , Schramm Marina , Kiebist Jan , Kubick Stefan
Published: November 2022

Unspecific peroxygenases (UPOs, EC 1.11.2.1) are fungal enzymes that catalyze the oxyfunctionalization of non-activated hydrocarbons, making them valuable biocatalysts. Despite the increasing interest in UPOs that has led to the identification of thousands of putative UPO genes, only a few of these have been successfully expressed and characterized. There is currently no universal expression system in place to explore their full potential. Cell-free protein synthesis has proven to be a sophisticated technique for the synthesis of difficult-to-express proteins. In this work, we aimed to establish an insect-based cell-free protein synthesis (CFPS) platform to produce UPOs. CFPS relies on translationally active cell lysates rather than living cells. The system parameters can thus be directly manipulated without having to account for cell viability, thereby making it highly adaptable. The insect-based lysate contains translocationally active, ER-derived vesicles, called microsomes. These microsomes have been shown to allow efficient translocation of proteins into their lumen, promoting post-translational modifications such as disulfide bridge formation and N-glycosylations. In this study the ability of a redox optimized, vesicle-based, eukaryotic CFPS system to synthesize functional UPOs was explored. The influence of different reaction parameters as well as the influence of translocation on enzyme activity was evaluated for a short UPO from Marasmius rotula and a long UPO from Agrocybe aegerita. The capability of the CFPS system described here was demonstrated by the successful synthesis of a novel UPO from Podospora anserina, thus qualifying CFPS as a promising tool for the identification and evaluation of novel UPOs and variants thereof.