bluuebunny/crossref_metadata_2025 huggingface dataset:
The Canvas learning management system: integrating educational philosophy, communication, delivery and tools
Authors: Stewart Benjamin L.
Published: June 2021

Los educadores como diseñadores del aprendizaje primero crean un template environment, el cual es un espacio donde es más probable que el aprendizaje se  pueda  llevar  a  cabo,  para  después  guiar  a  los  estudiantes  a  través  de  un  “viaje nómada” en busca de un objetivo global de aprendizaje. Con este fin, los educadores se benefician al reflexionar sobre una filosofía educativa, el tipo de comunicación utilizada en clase, y la manera de entregar la información colectiva, considerando las herramientas web apropiadas, o tecnologías de la información y la comunicación (TIC) que se pueden emplear. 

(Texto completo en el idioma Inglés)
Competencias docentes en educación superior
Authors: Alcántar Hernández Lina Aleida
Published: June 2021

El auge que actualmente tiene la metodología por competencias en el ámbito de la educación, se debe en parte a los cambios que se han dado en la sociedad, lo cual ha derivado en modificaciones al interior de las instituciones educativas. De acuerdo con lo anterior, en las universidades se aprecian en los siguientes aspectos: 1) los estudiantes son autónomos en la adquisición del aprendizaje, utilizando varias herramientas digitales; 2) la empleabilidad, pues una carrera universitaria ya no es suficiente para obtener un empleo más o menos rápido al egresar; 3) los estándares en la calidad de la educación universitaria; 4) el conocimiento, el cual debe ayudar a la formación de profesionales que se desempeñan en diversosescenarios de trabajo; 5) el profesor ahora debe centrar su actividad docente en el aprendizaje de los estudiantes y no en la enseñanza. Como resume Zabalza (2006), existen cambios en tres niveles: el escenario institucional, la estructura del conocimiento y el papel a desarrollar por el profesor.
Metodologías didácticas centradas en el aprendizaje
Authors: Pirela Sánchez Gabriela
Published: June 2021

Las exigencias de la educación en la actualidad requieren vincular a los estudiantes con el mundo real en el cual se desempeñarán como futuros profesionistas. En este espacio se ofrece un panorama de cinco metodologías recomendadas, a fin de lograr una enseñanza centrada en los estudiantes: algunos antecedentes, sus fases básicas, los roles de los principales actores educativos (el profesor y el estudiante), así como la evaluación del desempeño. Con lo anterior, se espera contribuir para la reflexión, la aplicación y el avance de este gran reto.
El Método de Diseño Arquitectónico en la UAA. Estrategia para que el estudiante de Arquitectura reconozca su proceso creativo
Authors: Torres Landa López Alejandra , Martínez Moreno Gabriela , Mercado Díaz de León Francisco
Published: June 2021

El proceso creativo es diferente en cada persona, si el estudiante identifica cómo diseña podrá reproducir los aciertos y evitar los errores en futuras ocasiones. Éste es uno de los motivos por los que en la carrera de Arquitectura se utiliza el Método de Diseño Arquitectónico, propuesto por maestros del Centro de Ciencias del Diseño y de la Construcción de la Universidad Autónoma de Aguascalientes (UAA) (Andrade et al., 1997). El propósito de este artículo es dar a conocer cómo se emplea este método en la materia de Diseño Arquitectónico II de tercer semestre de la carrera de Arquitectura de la UAA, con el cual el estudiante sistematiza y comprende su propio proceso creativo, de tal manera que el diseño de sus propuestas arquitectónicas no es simplemente un ejercicio de ensayo y error.
Evaluación y creatividad individual como vía de aprendizaje en estudiantes vulnerables
Authors: Márquez Elías Miguel Ángel
Published: June 2021

En este trabajo se expone una aplicación constructivista a la enseñanza y el aprendizaje del álgebra elemental en un grupo de estudiantes vulnerables de bachillerato cuya característica consiste en demostrar un pobre conocimiento del álgebra básica de secundaria. La estrategia de enseñanza fue contingente, basada en los resultados de varios exámenes evaluativos. Se habían preparado notas “base” según un conocimiento esperado. Parte esencial de la estrategia consistió en conducir a los alumnos a la construcción creativa de sus propios problemas algebraicos y su solución tanto en clase como para tarea, devolución de problemas con dificultad creciente por el docente, tareas diarias y tutorías de algunos de los estudiantes del mismo grupo fuera de clase. Los resultados reflejaron logros que fueron más allá de las expectativas iniciales planteadas en las notas base.
Más allá del reconocimiento: la evaluación externa de programas educativos
Authors: Cardona Esparza Elsa María , Cisneros Guzmán Lilia Beatriz , Fresán Sánchez Diego , Mojica Carrillo Elena Patricia
Published: June 2021

Los programas educativos de la UAA se han sometido a procesos de evaluación externa nacionales e internacionales con la finalidad de asegurar su calidad. Como resultado, la Universidad ha obtenido un sinnúmero de reconocimientos colocándola como un referente de calidad a nivel nacional, además de haber dejado importantes aprendizajes para toda la comunidad universitaria.Para este artículo, se entrevistó a profesores que han participado en dichos procesos.  Con base en sus aportaciones se definieron beneficios generados a partir de la evaluación externa: responsabilidad, conocimiento de la Universidad, acción y transformación, trabajo colaborativo, crecimiento profesional y personal, mejora continua, e identidad y sentido del porqué hacer las cosas.La experiencia obtenida de los procesos de evaluación externa abre una puerta para que toda la comunidad universitaria se involucre en ellos con una actitud abierta al cambio, con responsabilidad ética y social, privilegiando la formación humanista que rige a la institución.
Reseña del libro: La voz del aprendizaje liberal
Authors: Martínez Romero Miguel Ángel
Published: June 2021

Preocupado por el desarrollo de la filosofía de la educación, Michael Oakeshott expone en las seis conferencias que componen “La voz del aprendizaje liberal”, libro del cual se presenta una reseña en las siguientes páginas, una ruta a la cumbre del pensamiento educativo. El lector se encuentra frente a una reflexión filosófica con elementos antropológicos (metafísicos), puesto que no puede haber educación si no hay persona, así como ante una exhortación vitalicia a exigir una mejora en la educación.
¿Por qué dejamos de hacer preguntas?
Authors: Pájaro Huertas David
Published: June 2021

El presente ensayo es el resultado de la experiencia del autor como investigador y profesor en la especialidad de Edafología del Colegio de Postgraduados en Ciencias Agrícolas del campus Montecillo, Estado de México, durante los últimos treinta y cinco años; y es parte de una crítica extensa a la forma de desarrollar investigación en la especialidad de Edafología. Se postula que hacer preguntas es algo básico en una institución de investigación; sin embargo, el contexto escolar va en contra de este planteamiento, por lo que aquí se aborda no sólo dicha reflexión sino ¿qué hacer con esta situación?, de forma que se realicen preguntas esenciales, y de esta forma estar preparados para aprender, y, por tanto, para ser capaces intelectualmente de encontrar nuestro propio camino.
El reto de formar y capacitar docentes en el desarrollo de competencias digitales
Authors: Brand Barajas Jennie
Published: June 2021

La función esencial de la universidad es ofrecer espacios y recursos para que los estudiantes aprendan los saberes más elevados desde los cuales solucionen problemas y, creen recursos pertinentes a su comunidad y su tiempo. La actual crisis de las instituciones, el demérito de su lugar social, debilitan la acción de las universidades y les impone mayores retos para conservar su solidez en medio de una sociedad líquida. Uno de los desafíos más urgentes es reducir las brechas que existen entre los docentes y los estudiantes en cuando al dominio de los recursos digitales, ante este escenario, se vuelve necesario integrar las competencias digitales a los modelos educativos, lo cual representa un gran reto en lo referente a la formación de los docentes.Cumplir con este objetivo requiere de un plan de formación y capacitación docente en competencias digitales. Sumado a esto, en cada institución debería conformarse un equipo académico especializado en innovaciones digitales, encargado de actualizar los recursos y los medios para ofrecer a los estudiantes una educación de primer nivel, en la que puedan desarrollar competencias digitales adecuadas para los contextos laborales que enfrentarán.
Flipped Classroom: modelo educativo centrado en el alumno
Authors: Ramírez Arturo Elías
Published: June 2021

Las tecnologías de enseñanza han cambiado dramáticamente durante los últimos 15 años. A medida que las nuevas tecnologías están disponibles, se adecuan a la innovación educativa en un intento por mejorar la enseñanza tradicional. Flipped Classroom (Aula Invertida) es uno de los modelos más recientes y populares de enseñanza, que se sustentan en el uso de la tecnología y que fue acuñado por los profesores Jonathan Bergmann y Aaron Sams del Instituto Woodland Park en Colorado, de Estados Unidos de América, en el 2007 (Bergmann y Sams, 2012). Los principios básicos del modelo de enseñanza de Aula Invertida consisten en proporcionar contenido en línea fuera del aula y motivar el aprendizaje activo en el salón, mediante actividades, para la aplicación de conceptos, facilitadas por el profesor en clase.
Currículum, vida y cultura: una aproximación filosófica
Authors: Esparza Urzúa Gustavo Adolfo
Published: June 2021

El objetivo del presente trabajo es reflexionar acerca de la relación entre el currículum –en tanto que instrumento pedagógico–, la vida cotidiana –como marco general de desarrollo–, y la cultura –como producto curricular. Mi interés se centra en el vínculo que existe entre el diseño de planes y programas y los fundamentos que favorecen que el currículo opere como agente constructor de la vida cultural.
Pedagogía creativa, una estrategia docente en el nivel medio superior
Authors: Muñoz Arellano José Manuel
Published: June 2021

Haciendo un análisis de la educación tradicional y la actual, podemos encontrar que algunos elementos han cambiado por completo: la participación del alumno, las técnicas, las metodologías, los roles y el aprendizaje. De igual manera, aumenta la necesidad de prácticas que permitan a los alumnos interesarse en lo que están aprendiendo; sin embargo, no es sencillo mantener esta motivación hacia el conocimiento, los docentes nos hemos convertido en verdaderos artistas construyendo escenarios educativos cada vez más favorables, con la ayuda de la tecnología, dinámicas, juegos, paseos, entre otros, posibilitando nuevas experiencias que detonen aprendizajes para la vida. Desafortunadamente, hay momentos en los que se acaban las ideas y los recursos, por ello la importancia de fortalecer este talento creativo, que permita diseñar experiencias significativas de enseñanza para conducir de manera diferente el proceso educativo de nuestros alumnos, apoyándonos en una pedagogía creativa.
Recursos educativos abiertos
Authors: Torres Guzmán Lorena Lizbeth
Published: June 2021

Los recursos educativos abiertos son definidos por la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (UNESCO, 2017) como “[…] materiales de enseñanza, aprendizaje o investigación que se encuentran en el dominio público o que han sido publicados con una licencia de propiedad intelectual que permite su utilización, adaptación y distribución gratuitas”. En este artículo se presentan seis recursos abiertos a disposición del docente y, del estudiante para la autogestión de su propio aprendizaje.
Conocimiento del profesor universitario para enseñar matemáticas. Énfasis en lo pedagógico
Authors: Arceo Luna Ana Rosa , Páez David Alfonso
Published: June 2021

El profesor universitario tiene un conocimiento disciplinar y pedagógico inmerso en su práctica docente, el cual se enmarca en las demandas de la disciplina, así como el contexto educativo y el currículum. El modelo Conocimiento Matemático para la Enseñanza (MKT, por sus siglas en inglés) es una propuesta que permite analizar la acción del profesor, en particular la relación entre el conocimiento del contenido matemático y de los estudiantes, así como la didáctica específica de la disciplina y las demandas curriculares. El presente artículo discute este modelo desde la perspectiva de la educación superior, donde los profesores que enseñan matemáticas presentan mayores retos en su quehacer pedagógico.
La internacionalización de la UAA a través de las TIC
Authors: Arias Ulloa Raúl
Published: June 2021

A 45 años de la creación de la Universidad Autónoma de Aguascalientes [UAA], ésta ha transitado por una transformación continua, logrando posicionarse, en este momento, a nivel nacional por la calidad de sus programas educativos y de sus egresados. Sin embargo, las circunstancias actuales de globalización en todos los ámbitos, incluyendo las tecnologías de la información y la comunicación que ponen al alcance de todo mundo los servicios educativos, hacen necesario plantear el objetivo de comenzar la internacionalización de la institución mediante la oferta de cursos a través de estas tecnologías, aprovechando la experiencia con que ya cuenta la Universidad en este campo.
Психологічні особливості використання видів арт–терапії в різні вікові періоди
Authors: Бохонкова Юлія , Пелешенко Олена , Кобиляцька Марина
Published: June 2021

Стаття присвячена теоретико-методологічному розгляду напряму арт-терапія, психологічним особливостям використання видів арт- терапії в різні вікові періоди. У статті зроблено аналіз останніх досліджень і публікацій з зазначеної проблематики. Розглянуто науковий і прикладний зміст основ арт-терапії. Наведено опис видів арт-терапії, представлено теоретичний аналіз напрямків. Розглядаються методи психотерапевтичної, психодіагностичної, психокорекційної роботи з особливими психологічними запитами клієнтів. Проаналізовано завдання та функції арт-терапевтичної діяльності. Визначено основні специфічні особливості напряму арт-терапії. Акцентується увага на використанні видів арт-терапії в різних вікових групах. В статті робиться акцент на практичне застосування арт-терапевтичного напряму у вирішенні низки психологічних проблем. Зазначено можливості використання методів і технік арт-терапії в психології, медицині, педагогіці, соціальній роботі. Визначено можливості та переваги арт-терапевтичної діяльності в дитячій психології. Зроблено акцент на гармонізацію внутрішнього стану клієнта, відновлення його здатності знаходити рівновагу, стабілізувати емоційний стан за допомогою напряму арт-терапія.
Ключові слова: арт-терапія,мистецтво,психокорекція, психотерапія, психодіагностика, психотерапія мистецтвом, ізотерапія, піскова терапія, терапія пластичними матеріалами, казкотерапія, лялькотерапія, музикотерапія, танцювальна терапія, мандалотерапія, МАК, фототерапія.
Соціально-психологічні особливості розвитку стресостійкості особистості
Authors: Бочелюк Віталій , Застело Анна
Published: June 2021

У статті подано результати аналізу основних теоретичних підходів психології до дослідження проблеми стресостійкості особистості. Наведено основні поняття стресу та стресостійкості. Стаття присвячена розгляду причин утворення стресу на основі психологічних теорій стресу і конфлікту (як фактора стресоутворення) і адаптації до стресових ситуацій. Також в статті виявлені психологічні фактори і проаналізовані соціальні чинники, що впливають на формування стресостійкості.Виділені і охарактеризовані різні основні підходи до вивчення стресу і стресостійкості. Психологічні чинники стресостійкості розглядаються в ході кожного підходу, наголошуючи на необхідності розвитку особистості для стійкості до стресу. Аналіз фундаментальних досліджень стресостійкості показує, що більшість дослідників розуміють це як властивість психіки, що формується в онтогенезі і відображає здатність людини успішно здійснювати необхідну діяльність в стресових умовах.
До вивчення стресостійкості, як цілісної системи, пропонується комплексний підхід до дослідження природи і чинників стресостійкості, що враховує всі взаємодоповнюючі підходи і описує один або кілька компонентів комплексного формування стресостійкості особистості.
За результатами теоретичного аналізу літератури виявлена часткова залежність стійкості до стресу від типу нервової системи, особливостей темпераменту та інших нейрофізіологічних показників; показані два типи психологічних механізмів: механізми психологічного захисту (компенсації) і механізми самоволодіння, психологічні механізми подолання стресу, які мають свідомі і несвідомі компоненти когнітивної сфери психіки, активні і пасивні варіанти, які існують паралельно і функціонують комплексно; пояснюються фактори і способи підвищення стійкості до стресу.
Ключові слова: стрес, стресостійкість, стресоутворення, конфлікт, адаптація до стресових ситуацій, психологічні фактори, соціальні чинники.
До питання про структурно-феноменологічні характеристики психоемоційного здоров’я студентів
Authors: Кічук Антоніна
Published: June 2021

У статті обґрунтовано актуальність проблеми розробки основ психоемоційного здоров'я здобувачів вищої освіти. В умовах відсутності чітких наукових уявлень про компонентно-структурний склад поняття «психоемоційне здоров'я особливості» дотично вікового стану її раннього дорослішання, загострюється проблематика психологічно значущих зв'язків між показниками вияву певних особистісних характеристик і досліджуваною інтегративною особистісною властивістю. Найбільш тісний зв'язок параметрів психоемоційного здоров'я сучасного студентства прослідковується з показниками вияву стресостійкості, соціально-психологічної адаптованості, суб’єктивного благополуччя, емоційної зрілістю, емоційним інтелектом. Відповідно до набутих результатів емпіричного дослідження створюється можливість розширити наукові уявлення про феномен «психоемоційне здоров’я особливості студента» це дозволить спрямувати дослідницький пошук щодо створення навчально - розвивальної програми, яка має на меті визначити основи психоемоційного здоров’я здобувачів вищої освіти, забезпечити розвиток їх здатності до самопізнання, самовідновлення, самозбереження здоров’я у психоемоційній сфері життєдіяльності , також розробити і втілити в освітній процес закладу вищої освіти механізми психологічного супроводу процесу збагачення психоемоційного здоров’я студентів. Ключові слова: психічне здоров’я, психологічне здоров’я, емоційне здоров’я, психоемоційне здоров’я студентів.
A Neglected Unusual Galeazi Fracture Dislocation In 12 Years Child: Management
Authors: Uddin Md Nasir , Islam Md Saiful , Chowdhury Mamunur Rashid , Khan Md Abul Kalam Azad , Hasan Md Rajibul , Ashik Md Sabbir Hasan
Published: June 2021

A galeazi fracture is defined as a fracture of the shaft of the radius with dislocation of the distal radioulnar joint (DRUJ). Isolated radial shaft fractures with or without DRUJ dislocation in children are unusual in clinical practice. If there is fracture the degree of angulation is measured and accordingly managed. A 12 years boy came to the casualty department of Community Based Medical College Hospital Bangladesh (CBMCH,B) with the history of fall from bicycle on out stretcher right hand 5 years back, diagnosed to have fracture shaft of right radius. X-ray examination revealed old fracture at the junction of the middle and lower third of right radial shaft with feature of nonunion with volar angulation 30° (180-1500) and interosseous angulation 150 (180-165°). Patients was operated by open reduction and internal fixation (ORIF) of the fracture using dynamic compression plate (DCP) and screws and we corrected the angulation to near normal status and also correction of DRUJ done to its near normal anatomy. Postoperatively wound healed well and patient achieved full range of motion by three weeks. Radiologically the fixation was satisfactory and at the 6 weeks fracture was united. In conclusion, an old unusual galeazzi fracture dislocation in a child below 14 years with volar / dorsal / interosseus angulation more than 150 and rotational angulation more than 30° must be managed surgically to get near normal anatomy of bone as well as near normal range of motion.

CBMJ 2015 January: Vol. 04 No. 01 P: 41-44
Effect of Ashwagandharishta on the lipid profile of male and female rats
Authors: Rahman Tasmina , Bhuiya Mohammad Salahuddin , Hasan Rakib , Choudhuri MSK
Published: June 2021

The effect of Ashwagandharishta on the lipid profile and chronic toxicity of both male and female Albino rats were observed for 51 days. Our results demonstrate that the treatment of the plant extract failed to exhibit any statistically significant change (increase/ decrease) in the serum cholesterol (Total), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride of the male rats. But the female rats showed highly (p<0.01) and very highly (p<0.001) significant decrease in the serum cholesterol (Total) levels of the medium and high dose treated groups respectively. Regarding HDL, ASG showed statistically significant decrease at low (p <0.05), medium (p<0.01) and high (p<0.001) dose treated female rats. The LDL level of the medium dose treated female rats were statistically significant (p <0.05). The serum Triglyceride decreased significantly at low (p<0.01) and high (p <0.05) dose treated female rats.

Jahangirnagar University J. Biol. Sci. 9(1 & 2): 59-68, 2020 (June & December)
Floristic composition and plant species diversity in and around the brickfield areas of Savar-Dhamrai region of Dhaka district
Authors: Islam Saiful , Shetu Shayla Sharmin , Rahim Md Abdur , Khan Saleh Ahammad
Published: June 2021

This study has confirmed the occurrence of a total of 181 species of vascular plants under 133 genera and 51 families and estimates the plant species diversity in and around the brickfield areas of Savar-Dhamrai region of Dhaka district. Of these, six species were pteridophytes, 175 were Angiosperms, and 144 species were economically important. Five families, composed of six species, belonged to Pteridophyta, 40 families, consist of 128 species, to Magnoliopsida (dicotyledons) and six families, comprised of 47 species, to Liliopsida (monocotyledons). Total of 161 species were herbs, 14 were shrubs, and only six were trees. Asteraceae with 14 species and Poaceae with 24 species were the largest family in Magnoliopsida and Liliopsida, respectively. Amaranthus L., Persicaria (L.) Mill., Solanum L. and Lindernia All. with four species each were appeared as the best representative genera in Mangoliopsida, while Cyperus L. with five species in Liliopsida. The species composition and diversity of abandoned brickfields were found to be higher than those of functional brickfields. A total of 42 (23.20%) species were common in both abandoned and functional brickfields of this region. Species composition in the abandoned brickfields of Savar and Dhamrai was mostly similar (64.15%). This study suggests to control and monitor the brickfields under the respective authorities to favor the formation and regeneration of natural vegetation in their neighboring areas.

Jahangirnagar University J. Biol. Sci. 9(1 & 2): 91-108, 2020 (June & December)
Three new Angiospermic (Orchidaceae) records from Bangladesh
Authors: Huda Mohammed Kamrul , Hoque Mohammed Mozammel , Alam Md Owahidul
Published: June 2021

Coelogyne schwadtkii Danell., Cleisostoma williamsonii (Rchb.) Garay. and Phalaenopsis difformis (Wall. ex Lindl.) Kocyan & Schuit. of the family Orchidaceae collected from southeast part of the country have been reported here as new angiospermic records for Bangladesh flora. Detailed critical examination of the specimens of these species has been made to confirm their taxonomic identification. Detailed taxonomic description with flowering time, ecology, geographical distribution, illustration and photographs of each species has been provided.

Jahangirnagar University J. Biol. Sci. 9(1 & 2): 123-132, 2020 (June & December)
Chromosomal study of Xanthomonas atrovariens 'Variegatum Monostrum' a member of Araceae
Authors: Warasy Ashma Ahmed
Published: June 2021

Abstract not available

Jahangirnagar University J. Biol. Sci. 9(1 & 2): 133-137, 2020 (June & December)
Novel Tie Method for the Fixation of a Brain Infusion Cannula in a Murine Model
Authors: Mun Seog-Kyun , Chang Munyoung
Published: June 2021

Although brain infusion cannula is a good method to deliver compounds directly into the brain, fixation of the brain infusion cannula is essential for successful delivery. Dental cements and adhesive gel are the commonly used materials for fixation of the infusion cannula. However, these materials take time to harden and occasionally, fixation may fail. Therefore, we developed a novel method to fix the brain infusion cannula. Brain infusion cannulas were implanted into seven Wistar rats using the novel tie method. One, three, and seven days after the surgery, displacement of the brain infusion cannula and cerebrospinal fluid (CSF) leakage were evaluated in all the rats. None of the animals showed displacement of the brain infusion cannula or leakage of CSF at any point of time. In this study, we showed the successful results of the novel tie method for fixation of the brain infusion cannula, which needs no additional materials. It only requires a thread which is used for skin sutures.
Website for scientific dissemination of research on problem-based learning with highschool chemistry teachers: Contexts of an investigation
Authors: Freitas Amanda Pereira de , Campos Angela Fernandes
Published: June 2021

The aim of this study was to carry out the scientific dissemination of research on problem-based learning (PBL) with highschool Chemistry teachers through a website and to investigate their opinions on this digital resource. Also, analyse the knowledge of teachers about PBL and its use in the classroom. The set of data was collected through of a semi-structured interview  conducted with ten highschool Chemistry teachers in the city of Recife - Pernambuco, Brazil. Analysis of data implied that teachers know PBL and that they use it in the classroom, however with some difficulties. In general, their opinions about the website were positive and significant. Most of them commented that the website will serve as a didactic support in the preparation of their lessons providing access to solutions to various problematic situations regarding different contents in chemistry. Furthermore, the website will allow basic education teachers to have access to knowledge that has been discussed in Brazilian universities.
Geração Z: Infecções Sexualmente Transmissíveis (ISTs) recidivas e emergentes
Authors: Mantovanelli Lucas Silva , Silva Igor Gabriel da , Silva Riole Leite da , Almeida Gilvan Barbieri de , Sousa Thainara Araújo de , Pereira Silas Antônio
Published: June 2021

A geração Z é definida no meio social como a geração tecnológica, que incluem os nascidos entre os anos 1995 e 2010, pouco é falado desta geração ao se referir doenças, já que pata todas as patologias já se existe conhecimento científico, mas por se tratar de uma geração tão tecnológica, não se sabe se esses jovens estão tão cientes dos riscos. Esta pesquisa tem por objetivo geral retratar e relação da geração Z com o ressurgimentos de ISTs já erradicadas e com as emergentes, além de relatar o papel dos pais na sociedade atual. Como método de pesquisa, foi realizado análise da literatura bibliográfica de caráter descritivo, foram selecionados artigos da área das ciências da saúde. Por fim, conclui-se com a presente pesquisa que conhecer tecnologia não basta se não utilizá-la de maneira correta, e saúde sexual é mais importante que qualquer outro meio no que se trata de reduzir casos positivos para ISTs.
Conceptual frameworks used in the evaluation of Telehealth initiatives: A scoping review protocol
Authors: Souza Vanessa de Lima e , Oliveira Ione Ayala Gualandi de , Caetano Rosângela , Ribeiro Gizele da Rocha , Santos Daniela Lacerda , Silva Angélica Baptista , Silva Rondineli Mendes da
Published: June 2021

A Telessaúde tem o potencial de resolver diversos problemas na assistência e gestão da saúde, aumentando a qualidade, acessibilidade, utilização, eficácia e eficiência dos serviços e reduzindo custos. Este artigo apresenta um protocolo de revisão de escopo que visa caracterizar os modelos conceituais e frameworks relacionados à implementação e avaliação de Telessaúde/Telemedicina publicados em repositórios indexados entre os anos 2000 e 2020, evidenciando as teorias subjacentes, conceitos/dimensões chave utilizados e tipos de avaliação envolvidos. O protocolo objetiva documentar os processos envolvidos no planejamento metodológico e execução de uma revisão de escopo abrangente, orientada pelas diretrizes do Joanna Briggs Institute, tendo sido desenvolvido usando o PRISMA-Protocols (PRISMA-P) 2015 Checklist. A estratégia PCC (população, conceito e contexto) sistematizou a busca por estudos publicados nas bases bibliográficas Medline, Lilacs, Scopus, Embase e Web of Science, cobrindo o período de janeiro de 2000 até dezembro de 2020. A seleção dos artigos será realizada em duas etapas (títulos e resumos, seguida da avaliação do texto completo dos artigos), por dois avaliadores independentes, com resolução das divergências realizadas por um terceiro revisor. Os resultados serão analisados de forma qualiquantitativa e organizados por temas. O relatório final da revisão obedecerá ao checklist presente no Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR). O protocolo foi registrado no Open Science Framework (doi: 10.17605/OSF.IO/9PWBQ).
Gyulladás és autoimmunitás Covid-19-ben
Authors: Szekanecz Zoltán , Szamosi Szilvia , Szűcs Gabriella
Published: June 2021

The course of COVID-19 has several stages according to the elapsed time and severity. Cytokine storm-induced multisystemic inflammatory syndrome (MIS) and consequent multiorgan failure occur in severe and critical phases. From a pathological point of view, there is important the co-presenting of inflammation (endothelitis) and microthrombotic events. Beyond respiratory failure, they may harm the cardiovascular and nervous system, the liver and the kidneys. COVID-19 may be associated also with production of autoantibodies and development of autoimmune diseases. Multisystemic inflammatory syndrome can be attenuated by corticosteroids, anti-cytokine antibodies and JAK inhibitors (“repurposing”). Most IL-6 inhibitors, and barici­tinib proved to be effective in several stu­dies, when applied in appropriate stage by MIS identification.
Radiopaque Chitosan Ducts Fabricated by Extrusion-Based 3D Printing to Promote Healing After Pancreaticoenterostomy
Authors: Pan Maoen , Zhao Chaoqian , Xu Zeya , Yang Yuanyuan , Teng Tianhong , Lin Jinxin , Huang Heguang
Published: June 2021

Long-term placement of non-degradable silicone rubber pancreatic duct stents in the body is likely to cause inflammation and injury. Therefore, it is necessary to develop degradable and biocompatible stents to replace silicone rubber tubes as pancreatic duct stents. The purpose of our research was to verify the feasibility and biological safety of extrusion-based 3D printed radiopaque chitosan (CS) ducts for pancreaticojejunostomy. Chitosan-barium sulfate (CS-Ba) ducts with different molecular weights (low-, medium-, and high-molecular weight CS-Ba: LCS-Ba, MCS-Ba, and HCS-Ba, respectively) were soaked in vitro in simulated pancreatic juice (SPJ) (pH 8.0) with or without pancreatin for 16 weeks. Changes in their weight, water absorption rate and mechanical properties were tested regularly. The biocompatibility, degradation and radiopaque performance were verified by in vivo and in vitro experiments. The results showed that CS-Ba ducts prepared by this method had regular compact structures and good molding effects. In addition, the lower the molecular weight of the CS-Ba ducts was, the faster the degradation rate was. Extrusion-based 3D-printed CS-Ba ducts have mechanical properties that match those of soft tissue, good biocompatibility and radioopacity. In vitro studies have also shown that CS-Ba ducts can promote the growth of fibroblasts. These stents have great potential for use in pancreatic duct stent applications in the future.
Cancer-Preventive Role of Bone Marrow-Derived Mesenchymal Stem Cells on Colitis-Associated Colorectal Cancer: Roles of Gut Microbiota Involved
Authors: He Ruohang , Han Chaoqun , Li Ying , Qian Wei , Hou Xiaohua
Published: June 2021

Background

Mesenchymal stem cells (MSCs) treatment showed promising results in inflammatory bowel disease in both rodent models and patients. Nevertheless, previous studies conducted conflicting results on preclinical tumor models treated with MSCs concerning their influence on tumor initiation and progression. This study is designed to demonstrate the role of bone marrow-derived MSCs and the potential mechanism in the colitis-associated colon cancer (CAC) model.

Methods

Bone marrow-derived MSCs were isolated from green fluorescent protein-transgenic mice, cultured, and identified by flow cytometry. Azoxymethane and dextran sulfate sodium were administrated to establish the CAC mouse model, and MSCs were infused intraperitoneally once per week. The mice were weighed weekly, and colon length, tumor number, and average tumor size were assessed after the mice were killed. MSC localization was detected by immunofluorescence staining; tumor cell proliferation and apoptosis were measured by immunohistochemistry staining of Ki-67 and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling assay, respectively. The colonic tumor tissues were isolated for RNA-seq, and fecal samples were collected for 16S ribosomal RNA sequencing of the microbiome.

Results

After injection intraperitoneally, MSCs migrated to the intestine and inhibited the initiation of colitis-associated colorectal cancer. This inhibition effect was marked by less weight loss, longer colon length, and reduced tumor numbers. Moreover, MSCs reduced tumor cell proliferation and induced tumor cell apoptosis. Furthermore, MSCs could inhibit chronic inflammation assessed by RNA-sequencing and promote gut microbiome normalization detected by 16S ribosomal RNA sequencing.

Conclusion

The results proved that MSCs could migrate to the colon, inhibit chronic inflammation, and regulate gut microbiome dysbiosis to suppress the development of CAC.
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
Authors: Luo Jiahui , Xu Tao , Sun Kai
Published: June 2021

N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, including autoimmunity, infection, metabolic disease, cancer, neurodegenerative diseases, heart diseases, and bone diseases. However, systematic knowledge of the relationship between m6A modification and inflammation in human diseases remains unclear. In this review, we will discuss the association between m6A modification and inflammatory response in diseases, especially the role, mechanisms, and potential clinical application of m6A as a biomarker and therapeutic target for inflammatory diseases.
Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation
Authors: León Yolanda , Magariños Marta , Varela-Nieto Isabel
Published: June 2021

Sphingolipids are bioactive lipid components of cell membranes with important signal transduction functions in health and disease. Ceramide is the central building block for sphingolipid biosynthesis and is processed to form structurally and functionally distinct sphingolipids. Ceramide can be phosphorylated by ceramide kinase (CERK) to generate ceramide-1-phosphate, a cytoprotective signaling molecule that has been widely studied in multiple tissues and organs, including the developing otocyst. However, little is known about ceramide kinase regulation during inner ear development. Using chicken otocysts, we show that genes for CERK and other enzymes of ceramide metabolism are expressed during the early stages of inner ear development and that CERK is developmentally regulated at the otic vesicle stage. To explore its role in inner ear morphogenesis, we blocked CERK activity in organotypic cultures of otic vesicles with a specific inhibitor. Inhibition of CERK activity impaired proliferation and promoted apoptosis of epithelial otic progenitors. CERK inhibition also compromised neurogenesis of the acoustic-vestibular ganglion. Insulin-like growth factor-1 (IGF-1) is a key factor for proliferation, survival and differentiation in the chicken otocyst. CERK inhibition decreased IGF-1-induced AKT phosphorylation and blocked IGF-1-induced cell survival. Overall, our data suggest that CERK is activated as a central element in the network of anti-apoptotic pro-survival pathways elicited by IGF-1 during early inner ear development.
The Participant Journey Map: Understanding the Design of Interactive Augmented Play Spaces
Authors: Mast Danica , de Vries Sanne I. , Broekens Joost , Verbeek Fons J.
Published: June 2021

Augmented Play Spaces (APS) are (semi-) public environments where playful interaction is facilitated by enriching the existing environment with interactive technology. APS can potentially facilitate social interaction and physical activity in (semi-)public environments. In controlled settings APS show promising effects. However, people’s willingness to engage with APSin situ, depends on many factors that do not occur in aforementioned controlled settings (where participation is obvious). To be able to achieve and demonstrate the positive effects of APS when implemented in (semi-)public environments, it is important to gain more insight in how to motivate people to engage with them and better understand when and how those decisions can be influenced by certain (design) factors. The Participant Journey Map (PJM) was developed following multiple iterations. First, based on related work, and insights gained from previously developed and implemented APS, a concept of the PJM was developed. Next, to validate and refine the PJM, interviews with 6 experts with extensive experience with developing and implementing APS were conducted. The first part of these interviews focused on influential (design) factors for engaging people into APS. In the second part, experts were asked to provide feedback on the first concept of the PJM. Based on the insights from the expert interviews, the PJM was adjusted and refined. The Participant Journey Map consists of four layers: Phases, States, Transitions and Influential Factors. There are two overarchingphases: ‘Onboarding’ and ‘Participation’ and 6statesa (potential) participant goes through when engaging with an APS: ‘Transit,’ ‘Awareness,’ ‘Interest,’ ‘Intention,’ ‘Participation,’ ‘Finishing.’Transitionsindicate movements between states.Influential factorsare the factors that influence these transitions. The PJM supports directions for further research and the design and implementation of APS. It contributes to previous work by providing a detailed overview of a participant journey and the factors that influence motivation to engage with APS. Notable additions are the detailed overview of influential factors, the introduction of the states ‘Awareness,’ ‘Intention’ and ‘Finishing’ and the non-linear approach. This will support taking into account these often overlooked, key moments in future APS research and design projects. Additionally, suggestions for future research into the design of APS are given.
Transcatheter Mitral Valve Replacement and Thrombosis: A Review
Authors: Ascione Guido , Denti Paolo
Published: June 2021

Mitral regurgitation is the most prevalent form of moderate or severe valve disease in developed countries. Surgery represents the standard of care for symptomatic patients with severe mitral regurgitation, but up to 50% of patients are denied surgery because of high surgical risk. In this context, different transcatheter options have been developed to address this unmet need. Transcatheter mitral valve replacement (TMVR) is an emergent field representing an alternative option in high complex contexts when transcatheter mitral valve repair is not feasible or suboptimal due to anatomical issues. However, TMVR is burdened by some device-specific issues (device malposition, migration or embolization, left ventricular outflow tract obstruction, hemolysis, thrombosis, stroke). Here we discuss the thrombotic risk of TMVR and current evidence about anticoagulation therapy after TMVR.
Growth Differentiation Factor 15 Predicts Cancer Death in Patients With Cardiovascular Risk Factors: The J-HOP Study
Authors: Negishi Keita , Hoshide Satoshi , Shimpo Masahisa , Kario Kazuomi
Published: June 2021

Background: Disease-related anorexia-cachexia is associated with poor prognosis of patients with cardiovascular disease (CVD) or cancer. Growth differentiation factor-15 (GDF-15) has emerged as a central regulator of appetite and body weight. However, the exact role of GDF-15 in lean patients has not been elucidated.

Aim: Our aim is to evaluate whether the association of GDF-15 with mortality, including cancer death, differs according to body mass index (BMI) level.

Methods and Results: We collected blood samples from 4,061 patients with CV risk factors who were enrolled in the nationwide practice-based J-HOP (Japan Morning Surge-Home Blood Pressure) study. Serum GDF-15 levels were determined by immunoassay analysis. During a mean follow-up period of 6.6 years, we observed 174 (6.7/1000 person-year) all-cause deaths, 68 (2.6/1000 person-year) cancer deaths, and 56 (2.2/1000 person-year) CV deaths. Patients were stratified according to the cut-points of GDF-15 at 1,200 ng/L and BMI at 22.5 and 25.0 kg/m2. The association between the GDF-15/BMI based study groups and each outcome was evaluated by Cox-proportional hazard models with adjustment for established risk factors. The multivariate Cox regression model showed that patients with elevated GDF-15 (≥1,200 ng/L) and low BMI (<22.5 kg/m2) were significantly associated with increased risk of all outcomes [all-cause death, hazard ratio (HR) 3.15, 95% confidence interval (CI) 1.85–5.34, p < 0.001; cancer death, HR 3.52, 95%CI 1.64–7.57, p = 0.001; CV death, HR 2.88, 95%CI 1.20–6.92, p = 0.018, respectively] compared to a reference group with non-elevated GDF-15 and normal BMI (22.5–25.0 kg/m2). In analyses of a subgroup with low BMI (<22.5 kg/m2), patients with elevated GDF-15 had 4.79-fold increased risk of cancer death and 11-fold greater risk of CV death when compared with patients with non-elevated GDF-15 (<1,200 ng/L) after adjustment for established risk factors.

Conclusion: In patients with CV risk factors, GDF-15 was associated with all-cause, cancer, and CV death. This relationship was especially remarkable in patients with low BMI. The serum GDF-15 levels in patients with low BMI might be a useful marker to identify the potential for anorexia-cachexia associated with CVD and cancer.
Development of An Individualized Risk Prediction Model for COVID-19 Using Electronic Health Record Data
Authors: Mamidi Tarun Karthik Kumar , Tran-Nguyen Thi K. , Melvin Ryan L. , Worthey Elizabeth A.
Published: June 2021

Developing an accurate and interpretable model to predict an individual’s risk for Coronavirus Disease 2019 (COVID-19) is a critical step to efficiently triage testing and other scarce preventative resources. To aid in this effort, we have developed an interpretable risk calculator that utilized de-identified electronic health records (EHR) from the University of Alabama at Birmingham Informatics for Integrating Biology and the Bedside (UAB-i2b2) COVID-19 repository under the U-BRITE framework. The generated risk scores are analogous to commonly used credit scores where higher scores indicate higher risks for COVID-19 infection. By design, these risk scores can easily be calculated in spreadsheets or even with pen and paper. To predict risk, we implemented a Credit Scorecard modeling approach on longitudinal EHR data from 7,262 patients enrolled in the UAB Health System who were evaluated and/or tested for COVID-19 between January and June 2020. In this cohort, 912 patients were positive for COVID-19. Our workflow considered the timing of symptoms and medical conditions and tested the effects by applying different variable selection techniques such as LASSO and Elastic-Net. Within the two weeks before a COVID-19 diagnosis, the most predictive features were respiratory symptoms such as cough, abnormalities of breathing, pain in the throat and chest as well as other chronic conditions including nicotine dependence and major depressive disorder. When extending the timeframe to include all medical conditions across all time, our models also uncovered several chronic conditions impacting the respiratory, cardiovascular, central nervous and urinary organ systems. The whole pipeline of data processing, risk modeling and web-based risk calculator can be applied to any EHR data following the OMOP common data format. The results can be employed to generate questionnaires to estimate COVID-19 risk for screening in building entries or to optimize hospital resources.
Applying User-Centered Design Methods to Understand Users' Day-to-Day Experiences Can Inform a Mobile Intervention for Binge Eating and Weight Management
Authors: Graham Andrea K. , Neubert Sarah W. , Chang Angela , Liu Jianyi , Fu Emily , Green Emilie A. , Kornfield Rachel , Nicholas Jennifer
Published: June 2021

Introduction: Weight loss apps to date have not directly addressed binge eating. To inform the design of a new mobile behavioral intervention that addresses binge eating and weight management, we applied user-centered design methods to qualitatively assess how target intervention consumers experience these conditions in their day-to-day lives.

Methods: The participants were 22 adults with self-reported obesity (body mass index ≥30) and recurrent binge eating (≥12 episodes in 3 months) who were interested in losing weight and reducing binge eating. The participants completed a digital diary study, which is a user-centered design technique for capturing individuals' day-to-day experiences in relevant contexts. Qualitative data describing the participants' experiences with binge eating and obesity were analyzed using thematic analysis. The results were then used to create personas (i.e., character archetypes of different intervention consumers).

Results: The participants described triggers for binge eating and indicated that binge eating and excess weight negatively impact their mental health, physical health, and quality of life. The resulting personas reflected five different struggles individuals with these health problems experience in managing their binge eating and weight.

Conclusions: Individuals with binge eating and obesity have varying precipitants of problematic eating as well as varying motivations for and challenges to behavior change. To meet the needs of all who seek intervention, an ideal intervention design will account for variations in these factors and be relevant to diverse experiences. Insights from the diary study and resulting personas will inform the next phases of the user-centered design process of iteratively designing prototypes and testing the intervention in practice.