bluuebunny/crossref_metadata_2025 huggingface dataset:
High Prevalence of Hearing Loss in Down Syndrome at First Year of Life
Authors: Raut Pradeep , Sriram Bhavani , Yeoh Annie , Hee Karen YM , Lim Sok Bee , Daniel Mary L
Published: December 2022

Introduction: Infants with Down syndrome (DS) are at higher risk of hearing loss (HL). Normal hearing at one year of age plays an important part in language development. An audit was conducted to determine the impact of the newborn hearing screening program on the incidence, type and timing of diagnosis of HL during first year of life. Materials and Methods: Infants with DS were scheduled for Universal Newborn Hearing Screening (UNHS) within 4 weeks of life. If they passed, they had a high-risk screen at 3 to 6 months. They were referred to the otolaryngology department if they did not pass the UNHS or the high-risk screen. Information was obtained from the computerised data tracking system and case notes. Infants born from April 2002 to January 2005 and referred to the DS clinic of our hospital were analysed. Results: Thirty-seven (82.2%) of 45 infants underwent UNHS, of which 12 (32.4%) infants did not pass. Of remaining 33 infants, 27 had high-risk screen done of which 14 (51.8%) did not pass. Twenty-eight infants were referred to the ear, nose, throat (ENT) clinic: 12 from UNHS, 14 from high-risk screens and 2 from the DS clinic. Eleven (39.2%) defaulted follow-up. Fourteen (82.3%) of 17 infants who attended the ENT Clinic had HL. Twelve (85.7%) were conductive, and 2 (14.2%) mixed. Nine (64.2%) had mild-moderate HL and 3 (21%) had severe HL. The mean age of diagnosis was 6.6±3.3 months. All were treated medically, plus surgically if indicated. By 12 months of age, the hearing had normalised in 4 (28.6%) infants and remained the same in 3 (21.4%). Five (35.7%) defaulted follow-up. Thirty-five out of 45 (77.8%) underwent complete hearing screen in the first year of life (UNHS & High-risk screen). Six out of 45 (13.3%) had incomplete screening. Fourteen out of 41 (34.1%) had HL of varying degrees. Four out of 45 (8.8%) did not have any audiological assessment in first year of life. Conclusion: The incidence of HL in the first year of life was high (34.1%). Eighty-five percent were conductive with 64.2% in mild-moderate range. One third of infants hearing normalized after treatment, one third remained unaltered and one third of infants did not attend follow-up. An aggressive approach involving early screening after birth and continued surveillance and early referral to appropriate agencies are essential for establishing timely diagnosis and treatment. Measures to reduce the high default rate during long-term follow-up are needed. Parent education and integrated multidisciplinary follow-up clinic may be useful.

Key words: Deafness, Trisomy, UNHS
How can we Improve Clinical Research in Clinical Practice with Better Research Outcome?
Authors: Woo Keng Thye , Wong Kok Seng , Lee Evan JC , Chan Choong Meng
Published: December 2022

This paper explains some of the difficulties doctors face when taking up a career in research. It describes the efforts by the government and the Ministry of Health (MOH) to nurture the Clinician Scientist Programme. The nature of research and the mindset of clinicians who are passionate about research are explored and the reasons which drive some of them to pursue a research career. It discusses the need to have structured training for research and how continuing research education is necessary for the researcher. The paper discusses the goals for research and how we can achieve better research outcomes and the importance of good mentorship. It suggests ways to engage more doctors in research in the restructured hospitals by overcoming some of the problems they encounter. Finally, it relates the Biomedical Science initiative of the government through the National Research Foundation and the various programmes in Translational Clinical Research available for clinicians who are keen on a research career. Key words: Translational research, Clinician scientists, Nature of research, Training in research
COMPARATIVE EVALUATION OF NUTRITIONAL STATUS SCORE IN ICU-HOSPITALIZED PATIENTS INDICATES HIGHER NUTRITIONAL RISK AMONG POST CABG SUBJECTS: A CROSS-SECTIONAL STUDY IN THE NORTH OF IRAN
Authors: Haghighatkhah Motahare , Ghorbani Zeinab , Vakilpour Azin , Pouryousefi Elahe , Balou Heydar Ali , Roshan Marjan Mahdavi
Published: December 2022

Objectives: The current cross-sectional study intended to provide a comparative evaluation of nutritional status in the intensive care unit (ICU)-hospitalized patients according to the reasons for admission.
Methodology: A total of 258 patients hospitalized for >24-hour in the ICU between February 2020- July 2021 were included. The subjects were categorized into five categories: burned injury (n=27), COVID-19 or other respiratory disorders (n=64), post coronary artery bypass graft surgery (post-CABG) (n=50), trauma (n=57), and miscellaneous causes (n=60). A modified Nutrition Risk in Critically Ill (mNUTRIC) score was applied to explore the nutritional status of the patients.
Results: On average, the patients were 58± 16 years old that 46% (n=119) of them were females. The mean± SD of mNUTRIC score among patients with burned 2±1 and COVID-19 or other respiratory disorders 2±1 tended to be significantly lower than the others, including post-CABG 3±0 and patients with miscellaneous causes 3±2 (p-value=0.001). According to mNUTRIC score classifications, the majority of those who were transferred to ICU with burn or COVID-19 or other respiratory disorders were at low nutritional risk (mNUTRIC score:0-<3) (66.70%, and 67.20%, respectively); whereas relatively all post CABG subjects were at intermediate nutritional risk (mNUTRIC score:3-<5) (n= 48, 96.00%). A greater proportion of subjects in the miscellaneous category (n=12, 20.00%) were at high nutritional risk (mNUTRIC score:5-9) (p-value <0.001).
Conclusion: It was revealed that approximately all post CABG and those admitted to ICU with miscellaneous causes were at a higher risk for impaired nutritional status and may require more in-depth evaluation for providing earlier nutritional support.
APPROACH OF WITHHOLDING P2Y12 INHIBITORS FOR URGENT CORONARY ARTERY BYPASS GRAFTING IN DIABETIC PATIENTS WITH ACUTE CORONARY SYNDROME
Authors: Seikh Ghulam Abbas , Ahmed Faisal , Shah Arshad Ali , Asad Syed Dilbahar Ali Shah , Ashfaq Fareheen , Shabnam Shabnam , Lashari Muhammad Nawaz
Published: December 2022

Objectives: To compare angiographic findings between diabetic and non-diabetic patients with acute coronary syndrome (ACS) along with feasibility of P2Y12 inhibitors withholding approach for urgent coronary artery bypass grafting (CABG) in diabetic (DM) patients with severe lesions.
Methodology: Consecutive ACS patients were included. P2Y12 inhibitors was hold in a certain number of diabetic patients with either left main (LM) or multi-vessel disease (MVD) on baseline angiogram, at the discretion of primary physician. Angiographic diseases severity was compared between diabetic and non-diabetics. The clinical management and outcomes of diabetic patients were further compared based on the deferred P2Y12 inhibitors approach.
Results: Out of 205 patients, 149 were males and 40.9% were diabetic. Involved vessel was LM in 19.8% vs. 16.6%; p=0.566, left anterior descending artery (LAD) in 62.8% vs. 39.3%; p=0.001, and right coronary artery in 27.3% vs. 45.2%; p=0.008 with MVD in 42.1% vs. 28.6%, p=0.047 of the diabetic and non-diabetic patients, respectively. P2Y12 inhibitors was hold in 59 diabetic patients who undergone urgent CABG with hospital stay of <5 days. In remaining 62 diabetic patients, 50 undergo coronary intervention and 12 undergo delayed CABG with hospital stay of >5 days due to P2Y12 administration.
Conclusion: The presence of DM showed a significant association with the involvement of the LAD artery. Most participants showed presence of MVD. By holding P2Y12 inhibitors reduces the perioperative bleeding and hospital stay.
INCIDENCE AND PREDICTORS OF PERMANENT PACEMAKER IMPLANTATION AFTER TRANS AORTIC VALVE IMPLANTATION (TAVI) – A SINGLE CENTER EXPERIENCE
Authors: Alam Maqsood , Irfan Ghazala , Ammar Ali , Akhtar Parveen , Aamir Kanwal Fatima , Saghir Tahir
Published: December 2022

Objectives: The objective of the study is to evaluate the incidence and predictors of permanent pacemaker (PPM) implantation in patients undergoing transaortic valve implantation (TAVI).
Methodology: This study was conducted at the “National Institute of Cardiovascular Diseases (NICVD) Karachi, Pakistan”. All the consecutive patients who underwent TAVI between July 2015 and February 2020 were included in the study. Patient data were extracted from Hospital TAVI Registry. We included patients with severe symptomatic aortic stenosis (AS) with moderate to high surgical risk as per “society of thoracic surgeon score (STS)” and “EURO II score”, underwent TAVI. Patients were stratified into two groups based on the implantation of PPM, demographic characteristics, clinical characteristics, co-morbid conditions, valve pathology, and procedural characteristics were compared between both groups.
Results: Among 100 patients included only 22 patients (22%) underwent PPM implantation. The indication for implantation of PPM for all patients was complete heart block. Clinical characteristics which shows statistical significance for PPM implantation are preprocedural left ventricular dysfunction (p=0.015), right bundle branch block (RBBB) p<0.001, and left anterior hemiblock (p<0.001) noted on ECG and post-deployment valve area post-procedure (p<0.001). Multivariate analysis showed that pre-procedure RBBB and large post-deployment valve area are independent predictors for PPM implantation in Post TAVI patients.
Conclusion: The incidence of PPM implantation in patients who underwent TAVI at NICVD is 22%. Preprocedural left ventricular dysfunction, RBBB, and post-procedure large post-deployment valve area were noted to be significant predictors for PPM implantation.
A Context-Based Examination of the Relationship between Teachers' Ability to Empathize and Their Ability to Manage the Classroom
Authors: BİÇER Sultan  Dilek , GÜLTEKİN Aykut , DOĞAN ATALAN Bircan , YEŞİLKAYA İrfan
Published: December 2022

Most of the time, people prefer to use their body language as a way to communicate without words. For empathy in these situations, you also need to be good at communicating without words. To understand what people are really thinking and feeling, you need to be able to read their body language and facial expressions. This takes empathy skills. Empathy helps explain things like illusions, feelings, and moral feelings. Empathy brings behaviors and feelings to the same level. Empathy is important on an instinctual level. Empathy first showed up in psychology, where it was found that when empathy worked, so did the therapy. People's lives have been shown to get better in places where empathy education is taught. Empathy makes life better, and it is a process that affects the whole person. Assuming that empathy has a big effect not only on relationships and behaviors but also on learning, this effect is likely to depend on how much empathy teachers show. Taking into account the existing body of literature pertinent to the topic at hand, the purpose of this study is to investigate, on the basis of this context, the relationship between the ability of teachers to demonstrate empathy and their capacity to manage a classroom.
“Somos todos extraterrestres! Será?”
Authors: Kreitlow Lempke Tamiris , Santos Cabral Taís , Rolin Lievore João Paulo , Pancieri Rúbia Mara , Oliveira Póvoas Matheus , Borges Corte Viviana , Barata Diógina
Published: December 2022

A origem da vida é um tema que desperta grande curiosidade no meio científico. Algumas teorias tentam explicar como a vida poderia ter surgido, mas ainda há muitas lacunas a serem preenchidas quando o assunto é “Como surgiu o primeiro ser vivo?”. Entretanto, percebe-se que tal assunto apresenta complexidade ao ser trabalhado em turmas de ensino médio, considerando ser um tema de grande abstração para a maioria dos estudantes. Nesse contexto, o ensino por investigação se apresenta como estratégia de grande potencial, para trazer a origem da vida como um mistério a ser desvendado pelos estudantes, através do levantamento de hipóteses, discussão e pesquisa prática, fugindo do ensino tradicional e das aulas expositivas. Este trabalho propõe uma sequência de ensino investigativa (SEI), para trabalhar o tema “Origem da vida”, que de acordo com o Currículo Básico Escola Estadual do Espírito Santo (2009), é estudado na 3ª série do Ensino Médio, desenvolvendo nos estudantes o pensamento científico, trazendo uma nova perspectiva no ensino da origem da vida por meio do ensino por investigação.

Palavras-Chave: ensino por investigação, método científico, ensino de biologia, protagonismo discente.
Conhecendo as proteínas por meio do ensino por investigação
Authors: Flores Leite Adriano , Rocha Gonçalves Paola , Mancini Karina
Published: December 2022

O ensino de Biologia apresenta-se desafiador e tem sofrido grande impacto com a disseminação crescente de fake news. No que concerne ao ensino de Bioquímica, o trabalho docente se torna ainda mais complexo, visto que se trata de um assunto de alta complexidade e abstração. Nesse sentido, tem-se observado grande apelo pelo desenvolvimento de recursos diversos para o ensino de Bioquímica no ensino médio, de modo a facilitar o trabalho docente e minimizar o grau de abstração que tanto dificulta a aprendizagem. Dessa forma, o presente trabalho propõe uma sequência didática investigativa sobre o conteúdo de proteínas como meio de aproximar o assunto do cotidiano dos alunos. A sequência didática investigativa é composta por quatro etapas, a saber: a) primeira etapa, denominada “O que são proteínas?”, que consiste na apresentação de um vídeo seguido de situações-problema que serão investigadas pelos discentes; b) segunda etapa, denominada “Descobrindo as proteínas por meio de experimentos práticos realizados em casa”, na qual os grupos irão realizar experimentos pesquisados por eles e/ou indicados pelo professor e gravarão vídeos demonstrando os experimentos para averiguação das hipóteses levantadas na etapa anterior; c) terceira etapa, denominada “Conhecendo a estrutura das proteínas”, na qual o professor fará uma explanação dialogada sobre a constituição e estrutura das proteínas; d) quarta etapa, denominada “Ressignificando os experimentos”, onde os grupos gravarão novos vídeos explicando os resultados obtidos nos experimentos após a terceira etapa. Devido ao contexto pandêmico, a atividade não foi aplicada com os discentes devido à baixa adesão às aulas remotas pelo Google Meet e por não ter havido tempo hábil para aplicação presencial quando do retorno. Ainda assim, a sequência didática pode se configurar como uma forma diferenciada de se tratar o assunto “Proteínas” no ensino médio.
Contribuições do "Fazer História em Quadrinhos" no processo de ensino-aprendizagem de Ciências
Authors: Antunes Rafael , Aoyama Elisa
Published: December 2022

Há muito tempo os desenhos estão presentes na história da humanidade para trazer informações e retratar a história. Com as Histórias em Quadrinhos não seria diferente já que esse meio de comunicação de massa tem atribuído a si, tanto desenhos quanto texto em um formato dinâmico que facilita a leitura, diminui a tensão e estimula vários aspectos da aprendizagem. As HQs como ferramenta pedagógica apresentam um grande potencial para serem aplicados em sala de aula, não somente como forma de entretenimento mas, mais importante que isso, como meio de informação podendo ser aplicadas no ensino-aprendizagem de crianças, jovens e adultos. Portanto, esse artigo, tem como objetivo expor as potencialidades do “fazer História em Quadrinhos (HQs)” enquanto ferramenta pedagógica no processo de ensino-aprendizagem de Ciências.
Meu metabolismo que lute!
Authors: Oliveira Póvoas Matheus , Mitsuko Aoyama Elisa , Da Cunha Teixeira Marcos , Carvalho Mancini Karina , Rocha Gonçalves Paola
Published: December 2022

A Bioquímica tem por objetivo esclarecer a forma e o papel biológico dos mecanismos e os processos químicos ocorridos nos organismos. O conjunto de todas as transformações químicas encontradas em organismos vivos é chamado de metabolismo. A maioria dos seres vivos obtêm energia por meio de processos metabólicos que envolvem a oxidação do carbono oriundo de nutrientes carbonados. A compreensão do funcionamento destas reações bioquímicas é importante para o entendimento da dinâmica entre o ambiente e organismos para os processos de obtenção de energia e de produção de moléculas, entretanto tais conhecimentos ocorram superficialmente dentro das escolas, de forma pouco explorada. Este trabalho objetiva-se apresentar uma proposta de atividade investigativa para ser aplicada em estudantes do ensino médio, visando o entendimento sobre as interações existentes entre as formas de obtenção de compostos orgânicos bioquímicos e de produção de energia nas células, com a compreensão dos processos químicos e biológicos relacionados; além disto, a atividade possibilita o estímulo à criticidade no desenvolvimento do método científico a partir da pergunta norteadora: “Como o motor do carro funciona? ”. A proposta é o desenvolvimento de uma Sequência Didática Investigativa sobre os processos de obtenção de energia na célula, de forma a envolver os alunos em análises e discussões, a partir da problematização e posterior levantamento de hipóteses e pesquisa, culminando com a produção de quebra-cabeça ilustrado sobre os processos metabólicos envolvidos na discussão.
Acarajé
Authors: De Oliveira da Conceição Luena , Furlan Marcos Roberto , Aoyama Elisa Mitsuko
Published: December 2022

Ensino de Botânica tem se mostrado de baixo interesse pelos discentes, em especial pela linguagem científica e falta de informação sobre sua relevância e utilização dos seus conteúdos no cotidiano. Além da botânica, para a maioria da sociedade, há carência de informações de diversos assuntos, o que pode gerar equívocos e problemas de relacionamentos interpessoais, como o preconceito e a intolerância. Pensando na disseminação do ensino de Botânica e da Cultura, em destaque a afro-brasileira, o estudo teve como objetivo elaborar e-book sobre uma receita típica para utilização no ensino de Botânica, e como material complementar aos livros didáticos, visando minimizar a Cegueira Botânica e contribuir para valorização da diversidade cultural. Para criação da estrutura do e-book foram utilizados o Canva (on-line) e o PowerPoint. Para elaboração do texto foi realizada a receita de acarajé, a descrição dos seus elementos botânicos e leitura de artigos sobre culinária ritualística afro-brasileira.  Na capa buscou-se trazer elementos que retratem o acarajé, pois o conteúdo deste trabalho gira em torno dele. Páginas de apresentação e introdução instigam os leitores a conhecerem o e-book, explicando como foi realizado e sobre o assunto abordado. Páginas seguintes fornecem receita de acarajé; informações de cada vegetal presentes na receita, que podem ser utilizadas nos processos de ensino-aprendizagem do conteúdo de Botânica e alfabetização científica; e página com curiosidades sobre a cultura afro-brasileira e o acarajé. Em consonância com o tema transversal Pluralidade Cultural, proposto pelos Parâmetros Curriculares Nacionais de 1997, o e-book apresenta caráter interdisciplinar e evidencia a Pluralidade Cultural, e apresenta-se como potencial recurso didático digital, e como subsídio para ensino de Botânica numa dimensão cultural, valorizando elementos do cotidiano do aluno. Portanto, a utilização de um prato típico como base para processo de ensino e aprendizagem de Botânica foi satisfatória, pois apresentou diversas vertentes.
Os desafios da EJA em tempos de pandemia
Authors: Pasqualli Roberta , Scortegagna da Silva Liliane , Gomes da Silva Vitor
Published: December 2022

A educação no contexto da pandemia global do novo Corona Virus Disease (COVID-19) está marcada na história como um período tomado por dúvidas, angústias e incertezas. O cenário de desespero sanitário, econômico e social brasileiro tem provocado reflexões e exigido mudanças intempestivas no modelo de educação que costumávamos chamar de normal. A Educação de Jovens e Adultos (EJA), que tem como princípios, entre outros, o respeito às diversidades e às especificidades dos estudantes, assegurando não apenas o acesso mas, também, a permanência, o sucesso e o êxito, sofreu grande impacto com a pandemia. Estudos como os de Cunha, Neves e Costa (2021), Fantinato, Freitas e Dias (2020), Cunha Júnior, Mateus, Lima e Menezes (2020), Silva, Freitas e Almeida (2021), entre outros, vem apresentando reflexões que auxiliam na compreensão, mesmo diante de um cenário de incertezas, do fenômeno educacional em estudo. Nesta direção, esta pesquisa teve como objetivo apresentar e analisar os desafios enfrentados por estudantes imigrantes haitianos da EJA na rede municipal de ensino no município de Chapecó -SC em tempos de pandemia. Metodologicamente, trata-se de uma pesquisa descritiva e de abordagem qualitativa. Foi feito uso de referenciais teóricos, análise documental e coleta de dados empíricos por meio de entrevistas. Como resultados aponta-se que a presença física em sala de aula é fundamental para os estudantes haitianos compreenderem, especialmente, as articulações necessárias entre a língua portuguesa e as atividades propostas pelos professores. As relações com os colegas de sala e com os professores também se destacaram como fundamentais para o alcance do papel da EJA para os imigrantes haitianos que estudam na rede municipal de educação chapecoense.
A desigualdade social, marcadores sociais e a meritocracia:
Authors: Santos Diego Vinícius Brito dos
Published: December 2022

Este trabalho aborda a desigualdade social, marcadores sociais (especificamente: raça, gênero e classe) e a meritocracia enquanto fatores que possibilitam compreender o fracasso escolar. Tal problemática consiste em buscar elementos que proporcionem entender o porquê de o fracasso escolar ser um dos maiores problemas do atual modelo educacional. Essa questão se faz necessária tendo em vista os visíveis retrocessos nos índices educacionais e na manutenção e agravamento de desigualdades estruturais da sociedade. Nesse sentido, o objetivo do trabalho é evidenciar que fatores sociais contribuem à manutenção e perpetuação do fracasso escolar. Para chegar a tal conclusão, esse estudo utiliza e analisa pesquisas, artigos e livros que tratam sobre a questão do fracasso escolar, para demonstrar que o sucesso escolar não depende do mérito ou esforço pessoal, já que o indivíduo, no seio da sociedade, é perpassado por fatores sociais, políticos, econômicos e históricos que podem influenciar contra ou a favor de seu sucesso no âmbito escolar.
Comercializando a dor das mulheres:
Authors: Mattos Elisa Mattos , Carvalho Alexandra
Published: December 2022

Em um mundo ocidentalizado no qual as propagandas são instrumentos discursivos que produzem representações sobre a realidade, as aulas de língua portuguesa devem inseri-las como objeto de estudo. Nessa esteira, o presente artigo tem como objetivo discutir uma proposta didática de leitura crítica da propaganda da Buscofem, intitulada "Todas as suas dores importam". A partir da discussão guiada de categorias da Análise de Discurso Crítica Generificada (GOMES, 2020), da Gramática do Design Visual (KRESS; VAN LEEUWEN, 1996) articuladas às discussões da Interseccionalidade (AKOTIRENE, 2019) e à Linguística Aplicada Crítica (MOITA LOPES, 2006; PENNYCOOK, 1997, 2001, 2006, 2010, 2017, 2021) algumas perguntas guiarão a leitura crítica, por exemplo: quais corpos estão presentes na propaganda? O que eles representam? Quais escolhas linguísticas estão presentes e como os recursos semióticos são dispostos? Quais efeitos de sentido que disso deriva? A expectativa é incitar discussões sobre como a propaganda utiliza de discursos de militância social a serviço do capital, do racismo e do cisheteropatriacado, a fim de mobilizar uma leitura crítica e ativa das/dos discentes.
Mediação de leitura literária e letramento literário na escola:
Authors: JAGHER CLEIDE MARIA , Santos Mariana , da Silva Araújo Vilma
Published: December 2022

A partir da concepção de “letramento literário enquanto o conjunto de práticas sociais que usam a escrita literária” (ZAPPONE, 2008), neste estudo, apresentamos algumas reflexões sobre educação literária e letramento literário escolar. Entre os apontamentos, reiteramos o lugar da literatura na escola, considerando a sua relevância ao indivíduo, devido ao seu caráter estético de sublimação do real e ao seu caráter humanizador (CANDIDO, 1995). Defendemos também a urgência de um espaço escolar que promova práticas de leitura literária plurais, um espaço democrático, uma vez que nossos alunos, fora do espaço escolar, participam de práticas diversas de letramento literário. Nesse sentido, como concebe Zilberman (2017), o professor deve promover o cotejo entre o patrimônio de cada leitor com o patrimônio social, histórico, político do grupo ou do público com o qual interage. De maneira que, para uma educação literária efetiva, é necessário “utilizar aquilo que a norma escolar rejeita como um suporte para dar acesso à leitura na sua plenitude” (CHARTIER, 1999). Como suporte teórico, buscamos os conceitos de letramento, letramento na cibercultura, multiletramentos, em Soares (2002; 2009), Kleiman (2004) e Rojo (2009), bem como as considerações sobre leitura literária na escola, de autores, como Rouxel (2013), Jouve (2013), Colomer (2003; 2007), Hansen (2005), Zilberman (2009; 2017), entre outros.
Mechanisms for preserving archaeological areas, a case study of the archaeological site of Zemmouri el-Bahri, Boumerdes
Authors: Bediar Adel , Sahli Fayçal , Alal Ahmed , Dehimi Salim
Published: December 2022

Cultural heritage expresses the identity and privacy of the previous societies, as it represents great importance to researchers in this field, and countries have taken steps to preserve it through legislative and technical mechanisms and procedures represented in protection schemes, and Algeria was among the first countries in protecting its archaeological sites, especially after the issuance of Law 04/1994 related to the protection of cultural heritage, Which gave a strong impetus in defining and protecting these sites, and the archaeological site of Zammouri al-Bahri is considered among the very important sites, as it includes several periods of time from prehistoric times to the present time, passing through the Roman and Islamic periods, this study came according to two stages, the first stage was the use of a georadar device to detect the boundaries of the site, and the second stage was the diagnosis and the most important appropriate solutions to treat the deterioration.
Euthanasia Dalam Perspektif Hukum Pidana Yang Berlaku Di Indonesia
Authors: Kasidin Sunarko , Karsono Karsono
Published: December 2022

The purpose of this research is to find out the picture related to euthanasia that occurs and applies in Indonesia. What if, due to technological advances, there is "taking other people's lives" or "letting other people's lives be stolen by death. This research uses normative legal analysis. The data collection method uses the snowball method to continuously dig from various sources, books, other related literature studies. The results of this study illustrate that 1) The perspective of the Criminal Code in Indonesia is that convicting a person is not only because he has committed an act that fulfills the elements. - only the elements of the formulation of offenses (criminal act, actus reus) but still have to be taken into consideration is the problem of whether or not the person concerned is accountable for his actions (criminal responsibility, men's rea), 2) As a philosophical basis regarding the prohibition of euthanasia states, all kinds of killings are against morals.
KAJIAN HUKUM PEMBERIAN IZIN POLIGAMI ISTRI PERTAMA DIKAITKAN DENGAN UNDANG-UNDANG PERKAWINAN DAN KOMPILASI HUKUM ISLAM
Authors: Firly Ubaidillah
Published: December 2022

Persoalan poligami seringkali menimbulkan polemik dan memunculkan pendapat di kalangan masyarakat. Hal ini disebabkan karena adanya sudut pandang yang berbeda dalam menilai dan memaknai poligami. Undang-undang No. 1 Tahun 1974 Tentang Perkawinan dan Dalam Kompilasi Hukum Islam (KHI) diatur tentang poligami antara lain disebutkan bahwa berpoligami hanya dibatasi dengan empat orang istri. Akan tetapi kebolehan itu mempunyai syarat yaitu tuntutan mampu berlaku adil terhadap istri-istri dan anak-anaknya yang secara tegas telah mengatur perihal poligami. Dalam memahami tentang poligami terjadi perbedaan sehingga menimbulkan pro dan kontra. Perbedaan tersebut terjadi dalam memahami poligami. Oleh karena itu, perlu adanya pemahaman yang lebih mendalam lagi untuk memahami poligami tersebut dan juga melihat kepada aspek sejarah pada masa pelaksanaan poligami baik pada masa Rasulullah dan juga melihat situasi dan kondisi masyarakat. Penelitian ini dilakukan dengan tujuan untuk mengetahui bagaimanakah ketentuan pemberian izin menurut Undang-Undang dan Kompilasi Hukum Islam. Penelitian ini menunjukkan bahwa pelaksanaan pemberian izin dari istri pertama untuk berpoligami sesuai Undang – undang No. 1 Tahun 1974 dan Kompilasi Hukum Islam. Karena dengan diizinkan istri maka poligami dapat dilaksanakan.
KEBIJAKAN PEMERINTAH DALAM PROGRAM PENDAFTARAN TANAH SISTEMATIS LENGKAP DI KABUPATEN CIREBON
Authors: Hamamah Fatin
Published: December 2022

Undang-Undang Dasar 1945, telah menegaskan bahwa Negara Indonesia adalah Negara yang berdasarkan hukum. Demikian pula soal tanah, pemerintah berkewajiban memberikan kepastian hukum terhadap status tanah yang dikuasai masyarakat atau badan usaha. Penyelenggaraan pendaftaran tanah akan menghasilkan suatu produk akhir berupa sertifikat sebagai tanda bukti kepemilikan hak atas tanah. Namun pada kenyataannya, hingga saat pelaksanaan pendaftaran tanah belum dapat sepenuhnya diwujudkan. Pelaksanaan pendaftaran tanah sistematis lengkap di Kabupaten Cirebon dimulai dari persiapan sosialisasi dan penyuluhan dan penetapan sarana kegiatan. Pembentukan dan penetapan panitia ajudikasi pendaftaran tanah sistematis lengkap, kemudian dilakukan pengumpulan dan pengolahan data yuridis tanah, pemeriksaan tanah, pengumuman. kemudian menerbitkan putusan pemberian hak atas tanah, pembukuan hak atas tanah, kemudian panitia ajudikasi menerbitkan dan menyerahkan sertifikat hak atas tanah kepada pemilik tanah..
A Role of Therapy that Targets Immune Checkpoint Proteins for the Treatment of Melanoma Brain Metastasis, Liver, Breast, Pancreatic Cancer and Pancreatic Adenocarcinoma
Authors: Mohammed Smaa Elsayed , Youssef Basma Aml , Ghonai Doaa Alaa , Ahmed Eman Fares , Mohammed Esraa Gharieb , Abdo Mai Ashraf , Mohammed Mai Essam , Hassan Rana Gharieb , Mohammed Reem  Mohammed , Abd Al-Azeem Rofida Ahmed , Swelem Sarah Adel , Salman Sarah Ouda , Al-aiyq Sarah Mohammed , Taha Toka Taha , Moawad Zainab Khalid
Published: December 2022

Checkpoint inhibitors are a type of immune therapy used to treat different types of cancers. These drugs block different checkpoint proteins, for example, CTLA-4, PD-1, and PD-L1 inhibitors.
They block proteins that stop the immune system from attacking the cancer cells.  Checkpoints are also described as a type of monoclonal antibody that antagonizes binding between B7 to CTLA-4 and PD-L1 to PD-1.
 Immune checkpoint inhibitors are used to treat BARCA mutated triple-negative breast cancer (TNBCS) in patients who do not respond to chemotherapy, and also in the treatment of highly mutated and solid tumors such as brain tumors, liver, and pancreatic cancers.
Immune checkpoint inhibitors exhibit an effect on solid tumors by suppressing CTLA-4, PD-1, and PDL-1. Anti-PD-1 is less toxic than anti-CTLA-4.
For melanoma Brain metastasis immune checkpoint therapy is more effective and Combination therapy has great efficacy and less toxicity which improves overall survival rather than individual therapy
liver cancer as hepatocellular carcinoma and cholangiocarcinoma used treatment with Genetics based therapy while using alternative immune checkpoint ligands, co-inhibitory (eg. LAG-3) or decreased t-cell infiltration causing therapy failure.
Clinical studies for pancreatic cancer have not been completed yet and treating PDA needs more research as immune checkpoint inhibitors is a new treatment against  PDA. A new potent class of nivolumab, pembrolizumab, and ipilimumab have been FDA approved.
For mutated tumors, Combination therapy between checkpoint inhibitors and chemotherapy has great efficacy and improves the city of life and overall survival, rather than individual therapy when using radiation or chemotherapy alone.
Comparative study on Various Tube Voltages and Contrast Media Doses in CT Pulmonary Angiography to detect Pulmonary Thromboembolism
Authors: Abdul-Qader Shaymaa Khalid , Fadhil Atheer Adnan
Published: December 2022

Background: Lowering the amount of iodinated contrast material and tube voltage may increase pulmonary artery opacification and thrombus identification without compromising picture quality.
Objectives: To explore the efficiency of using lower tube voltage and a lower contrast medium dose for conducting computed tomography for pulmonary angiography (CTPA) aiming to increase its accuracy in detecting pulmonary thromboembolism (PTE).
Subjects and Methods:100 patients scheduled for CTPA with a preoperative diagnosis of PTE were grouped into two: group A, (50 patients) got 1 mL/kg at 120 kV and group B, (50 patients) received 0.5 mL/kg at 80 kV.The technique of bolus tracking was implemented.Values of midpoint of multiple pulmonary artery divisions were used to assess attenuation.Significant values are those that exceed 300 Hounsfield units (HU). The dosage of radiation received by the patient, defined as the effective dose, was compared between groups.
Results: Total mean attenuationdata for the pulmonary arteries have shown to be substantially greater in group-B compared to group-A (39110.4HU vs. 335.97.9HU, P=0.001). Moreover, total dose length product (DLP) values were substantially lower in group-B (934.9 mGy.cm vs. 384.443 mGy.cm, P=0.001). While effective dose values have shown to be significantly lower in group-B (2.90.3 mSv vs. 13.21.8 mSv, P 0.001).
Conclusion: Low-kilovoltage technique and low quantity of iodinated contrast are useful in conducting (CTPA) with high accuracy in detection of pulmonary thromboembolism.
Changing the Trends in Surgery during the COVID-19 Times: An Experience from the Eastern Uttar Pradesh State, India
Authors: Pandey Pooja , Bharat Singh Sandesh , Gupta Ashutosh
Published: December 2022

Background: The COVID-19 pandemic has an immense effect not only on the social and economic lives of people but also on the surgical lives of surgeons, residents, nursing staff, and patients as well as ground level staff. Amidst this COVID pandemic, emergency surgeries were being done but at a decreased rate, whereas elective cases depended on the will of hospitals, surgeons, and patients. Study aims to promulgate a "Neo–Surgical Check Box" by amalgamating the WHO surgical checklist and the results obtained from the questionnaires.
Subjects and Methods: After receiving ethical clearance from the Institute Ethical Committee, an online questionnaire with 50 questions divided into three sections was distributed to 235 surgeons in Uttar Pradesh.
Results:Two hundred and eight surgeons had responded, out of which 154 were male and 54 were female. Only 41.4% (86) were actually conducting the surgery. The emergency surgery rate was 60.3%, whereas 18.6% of elective surgeries were done, 11.8% of surgeries were avoided, and the rate of minimal access surgery was 9.3%.
Conclusion: The "Neo-Surgical Check Box" will not only increase the number of surgeries per day but also provide protection to the healthcare workers while handling not only COVID-positive patients but also any airborne communicable diseases.
Perancangan Website Pada Kantor Camat Mulak Ulu Kabupaten Lahat Dengan Metode Waterfall Menggunakan Framework Laravel
Authors: Ramadhan Fernando gilang Putra , Marlindawati Marlindawati
Published: December 2022

The Mulak Ulu Sub-District Office of Lahat Regency provides public services to the community as the executor of regional techniques that act as Regency/City regional apparatus, regarding population data. At the Mulak Ulu sub-district office, Lahat district has problems in carrying out public services and conventional information dissemination has an impact that can reduce the accountability and accountability of the Mulak Ulu sub-district office in Lahat district. The research method used in this study is a sequential method. systematic process in the process will be more effective and efficient in designing a website-based system using the Laravel Framework which is a PHP framework composed of several integrated plugins
THE DYNAMICS OF LANGUAGE IN THE GOD OF SMALL THINGS
Authors: Mamta Rana
Published: December 2022

‘The God of Small Things’ is a literary masterpiece by Arundhati Roy that highlights the unconventional style of writing with a gamut of literary techniques employed using the non-sequential narrative and a meticulous use of dialect that serves to highlight the differences present between the various social groups of Kerala primarily in the 1960s. There are notable features in the novel that includes the use of non-standard English, which highlights dialect, and variations in syntax and word choice which represents the cultural and linguistic diversity of India in the characters and setting of the novel. There are numerous and detailed picturesque descriptions of the environment presented through a variety of language techniques in the novel which is truly the soul of the novel and also brings out distinctly the intertwined social and cultural setting of the life in India while exploring the themes of caste, love and power.
Creation and its Impact on the Strategy of the Modern Organizations
Authors: Bahia Aqila Kahtan
Published: December 2022

This research deals with creativity and the impact it exercises on modifying the strategies of modern organizations. Creativity here is addressed in terms of the basic approaches, elements and creativity strategies and its characteristics, as well as the relationship of creativity to change by knowing the characteristics of change and its causes and objectives, and then we learn about regulative creativity through studying the indicators and characteristics of regulative creativity as well Characteristics of creative organizations and obstacles to creativity and knowledge of strategies to deal with obstacles and then how to develop regulative creativity.
Assessment of Severity of Pancreatitis by Computerized Tomography Using Revised Atlanta Classification and Comparison with BISAP Clinical Scoring System
Authors: Sagi Srikanth , Bharati Keerthi
Published: December 2022

Background: Untreated acute pancreatitis can have high morbidity and mortality. It is a serious gastrointestinal emergency. Its incidence is approximately 51.0 % and it can cause both local and systemic problems. The diagnosis usually involves laboratory tests like amylase and lipase as well as an ultrasound exam. The ideal imaging test is a contrast-enhanced CT scan. This study used scoring systems based on laboratory and radiological investigations to determine the clinical progression and outcome.

Methods
: Patients who were diagnosed with acute pancreatitis and in whom computed tomography was done were included. From the imaging findings, the category and subcategory of acute pancreatitis and types of fluid collections were described in these patients using the revised Atlanta classification. BISAP score was calculated in all these patients. The clinical outcome assessed in these patients is the duration of stay in the hospital, mortality, presence of persistent organ failure, the occurrence of infection and need for intervention. Finally, the correlation between the Revised Atlanta classification and BISAP score was analyzed and compared with clinical outcomes.

Results: The analysis of the correlation between Revised Atlanta classification severity grade and BISAP score, among the n=57 patients with mild acute pancreatitis n=56, had BISAP score less than 3 and only one had BISAP score greater or equal to three. Among the n=25 patients graded as moderately severe acute pancreatitis, n=20 cases had a BISAP score of less than 3 and n=5 had BISAP score greater than or equal to three. Among the n=08 patients graded as severe acute pancreatitis, n=3 had a BISAP score of less than 3 and n=5 had BISAP score greater than or equal to three.

Conclusion: Standardizing nomenclature and facilitating proper documentation of a variety of imaging abnormalities in acute pancreatitis is made possible by incorporating the new Atlanta categorization system into daily practice. We can triage, predict, and treat patients with acute pancreatitis with greater precision by integrating the new Atlanta classification with BISAP clinical grading, significantly improving medical care.
Mid Shaft Clavicle Fractures- Plate vs Titanium Elastic Nail System
Authors: Kalluraya Suryakanth , Hosangadi A. A. , I Sandeep , M Nagendra Prasad
Published: December 2022

It was believed that “all clavicle fractures heal well” is no longer valid. Recent trend is towards operative management, consists of Pre-contoured plate or Titanium Elastic Nail System(TENS) application. Plate fixation remains the mainstay of treatment but Titanium Elastic Nail System application has gained attention in recent years. This study highlights the comparison between two most common modalities available for treatment of mid-shaft clavicle fractures.

Objectives:Compare the functional outcome using Neer’s scoring system, radiological outcome and secondary outcomes between two treatment groups.

Methods:Patients satisfying inclusion criteria were included in our study and randomized into Group A-operated with plate fixation and Group B-operated with TENS. Routine postoperative protocol and physiotherapy followed. Regular follow up carried out and assessed as per protocol.

Results: We had 15 patients in each group by end of our study. There was no significant difference between the two groups in terms of demographics, time to surgery, fracture types. Duration of hospital stay, mean fracture union time were significantly shorter and cosmetically more satisfied in TENS group. Operative time, length of incision, peri-operative blood loss was significantly higher in plate group and length of clavicle better restored. Functional outcome was excellent with no significant difference between two groups.

Conclusion:Both methods return the patients to their pre-injury functional levels without significant complications with excellent functional outcome. Titanium Elastic Nail System application has a shorter operative time, lesser duration of hospital stay, lower infection rate and better cosmetic outcome suggesting this is the preferred method with no comminution whereas plate fixation is superior in comminuted fractures.
Efecto del Abonamiento en el carbono orgánico del suelo y rendimiento de brócoli (Brassica oleracea var. Italica) bajo riego tecnificado
Authors: Rivera - Cano Lorgio Miguel
Published: December 2022

Se evaluó el efecto del abonamiento orgánico en el rendimiento de brócoli (Brassica oleracea var. Italica) cv. Paraíso y carbono orgánico del suelo (COS), en la localidad de Cayhuayna, Huánuco (09°58´12” Lat. Sur; 76°15´08” Long. Oeste; 1943 msnm), de noviembre del 2018   a febrero del 2019. Los abonos orgánicos fueron: T1 (kimelgran: 470,63 kg/ha), T2 (Biot-313,75 kg/ha) y T0 (200-120-60). Se empleó el Diseño de Bloques Completos al Azar (DBCA), con tres tratamientos y 3 repeticiones. No se presentaron diferencias significativas en el peso fresco de pella entre los tratamientos T1 (452,2 g) y T2 (375,2 g), del mismo modo con respecto al diámetro de pellas, para el T1 (13,66 cm) y T2 (12,81 cm). El mayor valor alcanzado en rendimiento correspondió al tratamiento T1 con 14,22 t/ha. En el contenido de carbono orgánico del suelo (COS) de 0 a 30 cm de profundidad hubo diferencias significativas para T1 y T2, donde el mayor incremento se obtuvo con el tratamiento T1, representado por 14,22 t/ha. No se halló diferencias estadísticas entre profundidades. No obstante, se determinó que la mayor acumulación de carbono se encontró para el T1 en los primeros estratos, 0-10 y 10-20 cm con 16,32 t/ha y 16,46 t/ha, respectivamente.
Palabras clave: COS, Materia orgánica, abonos, riego por goteo.
Larva urticante Automeris metzli (Salle, 1853) (Lepidoptera: Saturniidae) en áreas verdes urbanas de David, Chiriquí, Panamá
Authors: Collantes - González Rubén Darío
Published: December 2022

En áreas verdes urbanas de la ciudad de David, Provincia de Chiriquí, Panamá, se ha encontrado la presencia de una especie de larva urticante; por lo que el objetivo del presente estudio fue identificar dicha especie y actualizar su distribución en el país. Para ello, el material fue colectado con ayuda de un recipiente plástico y preparado con agua hirviendo, para su preservación en etanol al 70%. Seguidamente, se consultó literatura especializada para la identificación respectiva y se revisaron bases de datos de instituciones reconocidas, para verificar la distribución del insecto. De acuerdo con los resultados, la especie de larva encontrada corresponde a Automeris metzli (Salle, 1853) (Lepidoptera: Saturniidae), la cual también ha sido reportada recientemente en huertos de traspatio en Volcán, Chiriquí. Los antecedentes recabados indican que la especie está presente en otras partes del país; habiéndose reportado también en las Provincias de Darién, Panamá, Veraguas, Bocas del Toro y en poblados de la Comarca Ngäbe-Buglé. En conclusión, la especie de larva urticante encontrada en jardines de David, Provincia de Chiriquí, corresponde a Automeris metzli; la cual puede ocasionar afectaciones para la salud de las personas por erucismo, como dolor e irritación. Se recomienda evitar contacto directo y acudir al médico de ocurrir algún accidente con este u otros animales venenosos.
The acoustic and daylighting effects of external façade sun shading systems
Authors: Secchi Simone , Fausti Patrizio , Cellai Gianfranco , Parente Martina , Santoni Andrea , Zuccherini Martello Nicolò
Published: December 2022

External sun shading devices are increasingly used in sustainable buildings to reduce the greenhouse effect in the summer and the glare effect due to direct solar irradiation through transparent surfaces. The acoustic effects of these devices have been investigated in recent studies that suggest the possibility of optimising these elements to improve acoustic comfort in indoor environments, even with open windows. Nevertheless, there are few studies that analyse the combined effect of these devices on acoustic attenuation and improved daylighting. 
In this paper, the results of acoustics and daylighting simulations are reported, considering different dimensions, distances of the louvres and orientations of the façade. The main results of previous works concerning the effect of lining the bottom side of each louvre with sound-absorbing material are also briefly summarised. The acoustic effects of different configurations of the louvres are evaluated in terms of Insertion Loss in the façade plane. For the lighting simulations (daylight factor, daylighting uniformity and daylight glare probability), the variation of the shielding effect is studied considering the spacing between the louvres and the orientation of the façade for different times and seasons for latitude in the South of Europe.