bluuebunny/crossref_metadata_2025 huggingface dataset:
LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways
Authors: Liu Zhihui , Luo Sukun , Wu Meiqin , Huang Chong , Shi Huifen , Song Xiaojie
Published: November 2019

Cervical cancer (CC) is a prevalent gynecological cancer, and the patients with CC usually suffer from dismal prognosis. Long non-coding RNAs (lncRNAs) are demonstrated to serve as promising biological targets in human cancers. Gastric carcinoma proliferation enhancing transcript 1 (GHET1) has been revealed to function as an oncogene in several cancers, but it has never been investigated in CC. We proposed to examine the biological role of GHET1 in CC and the underlying mechanism and validated the up-regulated expression of GHET1 in CC cell lines. Loss-of-function assays demonstrated that down-regulation of GHET1 inhibited cell growth, migration and epithelial-to-mesenchymal transition (EMT) in CC. Furthermore, we validated that GHET1 down-regulation could inactivate AKT/mTOR and Wnt/β-catenin pathways, and that respective activation of these two pathways abrogated the inhibitive effect of GHET1 knockdown on CC cell growth, migration and EMT. Moreover, we unfolded a preliminary investigation on the modulation of GHET1 on AKT/mTOR and Wnt/β-catenin pathways. We found that GHET1 stabilized E2F6 mRNA through interacting with IGF2BP2, so as to regulate the activity of AKT/mTOR and Wnt/β-catenin pathways. Rescue assays also proved that GHET1 regulated these two pathways and CC cell growth, migration and EMT through E2F6. In conclusion, we revealed that down-regulation of GHET1 suppresses cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways, indicating GHET1 as a promising molecular biomarker for CC treatment improvement.
The Influence of Phonomotor Treatment on Word Retrieval: Insights From Naming Errors
Authors: Minkina Irene , Silkes JoAnn P. , Bislick Lauren , Madden Elizabeth Brookshire , Lai Victoria , Pompon Rebecca Hunting , Torrence Janaki , Zimmerman Reva M. , Kendall Diane L.
Published: November 2019

Purpose

An increasing number of anomia treatment studies have coupled traditional word retrieval accuracy outcome measures with more fine-grained analysis of word retrieval errors to allow for more comprehensive measurement of treatment-induced changes in word retrieval. The aim of this study was to examine changes in picture naming errors after phonomotor treatment.

Method

Twenty-eight individuals with aphasia received 60 hr of phonomotor treatment, an intensive, phoneme-based therapy for anomia. Confrontation naming was assessed pretreatment, immediately posttreatment, and 3 months posttreatment for trained and untrained nouns. Responses were scored for accuracy and coded for error type, and error proportions of each error type (e.g., semantic, phonological, omission) were compared: pre- versus posttreatment and pretreatment versus 3 months posttreatment.

Results

The group of treatment participants improved in whole-word naming accuracy on trained items and maintained their improvement. Treatment effects also generalized to untrained nouns at the maintenance testing phase. Additionally, participants demonstrated a decrease in proportions of omission and description errors on trained items immediately posttreatment.

Conclusions

Along with generalized improved whole-word naming accuracy, results of the error analysis suggest that a global (i.e., both lexical–semantic and phonological) change in lexical knowledge underlies the observed changes in confrontation naming accuracy following phonomotor treatment.
Vom Verschweigen zur späten Anerkennung der Opfer
Authors: Böcker Felix M.
Published: November 2019

Anlässlich der Wanderausstellung der DGPPN über „kranke und behinderte Menschen im Nationalsozialismus“ hat der Verfasser – vorwiegend anhand der eigenen Lektüre – den Versuch unternommen, den Umgang mit der Geschichte der Zwangssterilisierungen und Krankentötungen in den Jahren zwischen 1945 und 2010 nachzuzeichnen. Der Gang durch 7 Dekaden zeigt, dass mit der Dokumentation des Geschehenen unmittelbar nach dem Ende der nationalsozialistischen Diktatur in den Jahren 1945 bis 1948 begonnen wurde, wobei es Hinweise auf eine aktive und systematische Unterdrückung der Publikation der Befunde durch die ehemaligen Täter gibt; erst nach der Enquête des Deutschen Bundestages zur Lage der Psychiatrie und mit fast 4 Jahrzehnten Verspätung ergaben immer mehr lokale und regionale Berichte ein allmählich dichter werdendes Gesamtbild. Die „Aufarbeitung der Aufarbeitung“ ist eine Zukunftsaufgabe, mit der erst kürzlich begonnen wurde.
Früherkennung der Alzheimer-Demenz mit neuropsychologischen Methoden
Authors: Marczak Agnies
Published: November 2019

Die Früherkennung der Gedächtnisprobleme erfolgt vorwiegend mithilfe von neuropsychologischen Instrumenten. Da es noch kein wirksames Mittel zur Heilung der Erkrankung gibt, ist die Hemmschwelle und Angst vor der Diagnose hoch. Deswegen wird diese meist erst dann gestellt, wenn die Gedächtnisprobleme gravierend sind. Dieser Artikel soll eine kurze Übersicht über die oft verwendeten Instrumente, die Probleme der Testung und deren mögliche Lösungen vorstellen.
Empowerment und Stigma als Mediatorvariablen zwischen Krankheitsschwere und Lebensqualität bei Patienten mit einer affektiven Erkrankung
Authors: Panzirsch Maria , Frasch Karel , Kilian Reinhold
Published: November 2019

Ziel Die Analyse der Effekte von Empowerment und Stigma auf den Zusammenhang von Depressivität und subjektiver Lebensqualität bei Patienten mit affektiven Erkrankungen.

Methodik Messung von Depressivität (BDI-II), internalisiertem und wahrgenommenem Stigma (ISMI; PDDQ), Empowerment (EPAS) und subjektiver Lebensqualität (WHOQOL-BREF) bei 37 Patienten mit affektiver Erkrankung.

Ergebnisse Empowerment und in geringem Maße Stigmatisierung erwiesen sich als vermittelnde Variablen zwischen Depressivität und Lebensqualität.

Schlussfolgerung Empowerment hat einen bedeutenden Einfluss als Mediator zwischen Depressivität und Lebensqualität.
Urine Proteomics Profiling and Functional Characterization of Knee
Osteoarthritis Using iTRAQ Technology
Authors: Xiao Ke , Yu Lingjia , Zhu Lisi , Wu Zhihong , Weng Xisheng , Qiu Guixing
Published: November 2019

Osteoarthritis (OA) is a degenerative chronic disease affecting the whole joint
structures. With the increment in life expectancy and aging population, OA has
become one of the largest socioeconomic burdens, associated with pain and loss
of joint function. However, early laboratory tests of OA are still lacking.
Therefore, new diagnostic tests for this disease are urgently needed. In this
study, to gain an insight into the pathogenesis and the potential biomarkers of
OA, we implemented a comparative urine proteomics study on OA patients and
health people using iTRAQ-based mass spectrometry technology. Western blotting
was used to validate the relative changes in urine protein levels for four of
the identified proteins. We constructed a comprehensive urine proteome profile
of the OA patients and identified 102 proteins differently changed in abundance.
Forty-six proteins were upregulated and 56 proteins were significantly
downregulated in OA patients. Furthermore, the proteins, COL-4, MMP9,
adiponectin, and BBOX1 were validated through Western blots, which can serve as
valuable candidate biomarkers and help to illustrate the pathogenesis of OA.
These findings may provide clues for promising biomarkers for the early
diagnosis and also offer a theoretical basis for the early treatment of OA.
Unerwünschte Ereignisse durch unsachgemäß durchgeführte Psychotherapie
Authors: Gawlytta Romina , Schwartze Dominique , Schönherr Désirée , Schleu Andrea , Strauß Bernhard
Published: November 2019

Ziel der Studie In einer Pilotstudie wurde das neu entwickelte Inventar zur Erfassung von Kunstfehlern und Kunstfehlerfolgen in der Psychotherapie (IKKIP) erstmals eingesetzt, um die Häufigkeit therapeutischen Fehlverhaltens aus Patientensicht zu erfassen, die resultierende Belastung zu erheben und Prädiktoren zu identifizieren.

Methodik Ausgewertet wurden Daten von N = 165 Patienten mit Psychotherapieerfahrung, die an der Online-Befragung teilnahmen.

Ergebnisse Die Patienten berichteten im Mittel M = 16,21 Ereignisse, die im Sinne von Kunstfehlern interpretierbar sind, und zu einer Belastung mittelmäßiger Schwere führten. Während Ereignisse der Kategorie „Mangelhafte Diagnostik/Technikanwendung“ am häufigsten berichtet wurden, gingen sexuelle Grenzverletzungen mit dem höchsten Belastungsgrad einher.

Schlussfolgerung Die Ergebnisse belegen die Notwendigkeit einer differenzierten und systematischen Erfassung von Kunstfehlern und deren Folgen. Das IKKIP scheint dabei vor allem für den Forschungsbereich geeignet.
The Role of Magnetic Resonance Imaging of the Temporomandibular Joint to Investigate Tinnitus in Adults with Temporomandibular Joint Disorder: A Comparative Study
Authors: Lavinsky Danielle , Lavinsky Joel , Setogutti Enio Tadashi , Rehm Daniela Disconzi Seitenfus , Lavinsky Luiz
Published: November 2019

Introduction The prevalence of tinnitus is higher in individuals with temporomandibular joint disorder (TMD) than in the general population. Magnetic resonance imaging (MRI) of the temporomandibular joint (TMJ) is the method of choice for investigation, and it has been hypothesized that specific MRI findings might be observed in TMD with comorbid tinnitus.

Objective To comparatively describe MRI findings in patients with TMD with and without tinnitus, identifying the most common TMJ alterations and determining whether a correlation exists between severity of TMD and tinnitus.

Methods A cross-sectional study of 53 adult patients with bilateral or unilateral TMD (30 with and 23 without tinnitus). The association between tinnitus and morphological aspects of TMD (changes in condylar morphology, articular eminence morphology, and disc morphology), disc displacement (with/without reduction), condylar translation, and intra-articular effusion was analyzed on MRI images.

Results The mean patient age was 46.12 ± 16.1 years. Disc displacement was the most common finding in both groups (24 patients with tinnitus versus 15 without; p = 0.043). Only the frequency of disc displacement with reduction was significantly different between groups.

Conclusion Additional imaging techniques should be explored to detect specific aspects of the relationship between tinnitus and TMD.
Lateral-Expansion Pharyngoplasty: Combined Technique for the Treatment of Obstructive Sleep Apnea Syndrome
Authors: Pinto José Antonio , Godoy Luciana Balester Mello de , Nunes Heloisa dos Santos Sobreira , Abdo Kelly Elia , Jahic Gabriella Spinola , Cavallini André Freitas , Freitas Gabriel Santos , Ribeiro Davi Knoll , Duarte Caue
Published: November 2019

Introduction Obstructive sleep apnea syndrome (OSAS) is a multifactorial disease characterized by episodes of partial or complete collapse during sleep of different regions of the upper airway. Surgery for OSAS evolved with the introduction of different techniques, considering new surgical concept of reconstruction of the upper airway.

Objective To retrospectively evaluate the effectiveness of a new approach aimed at reducing pharyngeal collapse by combining two surgical techniques: lateral and expansion pharyngoplasty.

Methods We reviewed the medical records of 38 patients with OSAS undergoing lateral/expansion pharyngoplasty from January 2012 to December 2016. The following data were collected: patient age, gender, and pre- and postoperative body mass index (BMI), Epworth sleepiness scale (ESS) scores, snoring visual analogue scale (VAS) scores, and polysomnography (PSG) results.

Results The PSG results showed a significant reduction in the apnea/hypopnea index (AHI) from 22.4 ± 27.3 events/h preoperatively to 13.6 ± 17.9 events/h postoperatively (p = 0.009), with postoperative AHI reduction greater than 50% in 63.2% of the patients. There was also a significant reduction in the microarousal index (19.5 ± 22.6 vs 11.0 ± 13.4 events/h; p = 0.001) and in the minimum oxygen saturation (82.6 ± 10.3 vs 86.9 ± 11.1; p = 0.007).

Conclusions Lateral-expansion pharyngoplasty represents a new surgical strategy for the treatment of OSAS in patients with palatal collapse by combining two different techniques: lateral and expansion pharyngoplasty. The two techniques, performed as a one-stage procedure, led to improvements in excessive daytime sleepiness, snoring, and PSG respiratory parameters by acting on lateral and retropalatal collapse, producing favorable results with good applicability in otolaryngology clinical practice.
Mismatch Negativity Elicited by Verbal and Nonverbal Stimuli: Comparison with Potential N1
Authors: Brückmann Mirtes , Garcia Michele Vargas
Published: November 2019

Introduction Mismatch negativity (MMN) is a long latency auditory evoked potential, represented by a negative wave, generated after the potential N1 and visualized in a resulting wave.

Objective To identify the time of occurrence of MMN after N1, elicited with verbal and nonverbal stimuli.

Methods Ninety individuals aged between 18 and 56 years old participated in the study, 39 of whom were male and 51 female, with normal auditory thresholds, at least 8 years of schooling, and who did not present auditory processing complaints. All of them underwent audiologic anamnesis, visual inspection of external auditory meatus, pure tone audiometry, speech audiometry, acoustic immittance measures and the dichotic sentence identification test as a screening for alterations in auditory processing, a requirement to participate in the sample. The MMN was applied with two different stimuli, with these being da/ta (verbal) and 750 Hz and 1,000 Hz (nonverbal).

Results There was a statistically significant difference between the latency values of the N1 potential and the MMN with the two stimuli, as well as between the MMN with verbal and nonverbal stimuli, and the latency of the MMN elicited with da/ta being greater than that elicited with 750 Hz and 1,000 Hz, which facilitated its visualization.

Conclusion The time of occurrence of MMN after the N1 elicited with verbal stimuli was 100.4 ms and with nonverbal stimuli 85.5 ms. Thus, the marking of the MMN with verbal stimuli proved to be more distant from N1 compared with the nonverbal stimuli.
Perfusion Computed Tomography Scan Imaging in Differentiation of Benign from Malignant Parotid Lesions
Authors: Niazi Masume , Mohammadzadeh Maryam , Aghazadeh Kayvan , Sharifian Hashem , Karimi Ebrahim , Shakiba Madjid , Baniasadi Maria , Rahmaty Benyamin , Adel Suzan , Moharreri Melorina
Published: November 2019

Introduction The most common site of salivary gland tumors is the parotid gland. Computed tomography (CT), magnetic resonance imaging (MRI), and sonography are imaging modalities to differentiate benign from malignant parotid tumors.

Objective The aim of this study is the evaluation of the diagnostic value of perfusion CT for differentiating histological categorization of benign and malignant parotid tumors.

Methods A total of 29 patients with parotid neoplasms were enrolled in this study. Mean age and all CT perfusion variables (gradient and permeability, blood flow [BF], blood volume [BV], mean transit time [MTT], permeability surface [PS], maximum intensity projection [MIP], time-density curve [TDC], and time to peak [TTP]) were compared among three groups (malignant tumors [MTs], Warthin's tumor [WT] and pleomorphic adenomas [PA]).

Results The mean age of the patients was 55.9 ± 14.1 (26–77), and 15 of them were male (51.7%). Eleven lesions were PAs [37.9%], 8 lesions were WTs (27.6%0 and 10 lesions (34.5%) were MTs (6 acinic cell carcinomas [ACCs], 3 adenocystic carcinomas [AdCCs], and 1 mucoepidermoid carcinoma [MEC]). The mean age of the patients with WTs was 62 ± 7.5 years; 52 ± 14.2 for patients with Pas, and 55.2 ± 17.2 for those with MTs (p = 0.32). The mean MIP was 122.7 ± 12.2 in WT, while it was 80.5 ± 19.5 in PA, and 76.2 ± 27.1 in MTs (p < 0.001); The mean MIP for WT was higher than for PAs and MTs; the values of MTs and PAs were not statistically different. The average of BF, BV, and curve peak were higher in WTs in comparison with the other two groups, and curve time 2 and TTP were higher in PAs in comparison with MTs.

Conclusion Based on this study, perfusion CT of the parotid gland and its parameters can distinguish between benign and malignant parotid masses.
Morphometric Determination of Sex of Hyoid Bone
Authors: BM Sharada ,   Savitha V,   Sunitha R
Published: November 2019

Background and Objectives The hyoid bone shows sexually dimorphic features, which could be used in the sex determination aspect of establishing the biological profile in the remains of skeleton. The aim of this study was to investigate morphometrical variations of the hyoid bone in South Indian population.

Materials and Methods A total of 60 adult larynx specimens (30 male and 30 female) with attached hyoid bone were dissected out from postmortem cadavers. The infrahyoid muscles and thyrohyoid membrane were removed. Hyoid bone was dissected and dried completely. Total 10 measurements like length of each greater cornua, length of body, major transverse axis, total hyoid length on both the sides, breadth of hyoid, and height of body of hyoid were taken on each hyoid bone using a digital Vernier caliper.

Results The range, mean, standard deviation, and level of significance of all 10 parameters of hyoid bone were calculated using standard statistical method. Most of the parameters showed significant difference between the values of male and female hyoid bones.

Conclusion Values obtained for all 10 parameters of hyoid bone were higher in males compared with females, which is suggestive that male hyoid bones are larger in size compared with female hyoid bones.
Study of Pterygospinous and Pterygoalar Bars in Relation to Foramen Ovale in Dry Human Skulls
Authors: Singh Arvind Kumar , Niranjan Richa
Published: November 2019

Background Anatomical knowledge of bony bridges around the foramen ovale may be helpful for diagnostic and invasive neurosurgical procedures like electroencephalogram analysis, trigeminal rhizotomy, biopsy of cavernous sinus tumors, and mandibular nerve block.

Lateral pterygoid plate forms an important landmark for mandibular anesthesia; therefore, any variation related to lateral pterygoid plate is likely to create confusion during the maneuver of anesthesia.

Aims and Objective The aim of the study was to explore any bony obstacle within and around Foramen ovale. Obstacles in form of ossified complete or incomplete ligaments. Additional foramina formed by ligaments or any bony enlargement might disturb the structures passing through the Foramen ovale.

Methods Around 530 dried crania (from medical colleges in Uttarakhand and Uttar Pradesh) were observed to find ossified ligaments and foramen formed by them. Crania associated with bilateral enlarged lateral pterygoid plate other than the average width of 1.5 cm were included in this study. Length of ligaments and width of pterygoid plate were measured by digital Vernier calipers.

Results Out of 530 crania, unilateral 52 ossified pterygospinous ligament (incomplete 31 and complete 21) were observed. Among them some rare variation was found along with ossified pterygospinous and pterygoalar ligament, one cranium along with unilateral pterygospinous bar was also having bar within foramen ovale, forming an accessory osseous compartment, found to be rare kind of variation. Another unilateral complete pterygospinous bar was enclosing two foramens instead of one. Only single cranium was found to have pterygoalar bar, related medial to foramen ovale. One cranium was associated with bilateral enlarged lateral pterygoid plate (i.e., 2.5 cm) was also found to be obliterating the space, that is, retropharyngeal and parapharyngeal space for surgeons.

Conclusion This study would provide the anatomical knowledge of these bony bridges around the foramen ovale and may be helpful for diagnostic and neurosurgical procedure like microvascular decompression by percutaneous trigeminal rhizotomy for trigeminal neuralgia, percuatneous biopsy of cavernous sinus tumor and mandibular nerve block by lateral subzygomatic route. Thus, lateral pterygoid plate forms an important landmark for mandibular anesthesia.
Endoscopic Endonasal Transodontoid Approach for Degenerative Pseudotumor of the Craniocervical Junction
Authors: Venteicher Andrew S. , Goldschmidt Ezequiel , McDowell Michael M. , Wang Eric W. , Snyderman Carl H. , Gardner Paul A.
Published: November 2019

Ventral masses of the craniocervical junction threaten the medulla and upper spinal cord leading to lower cranial nerve dysfunction and myelopathy. Traditional transoral and newer endonasal approaches can access ventral pathology in this region, though both remain challenging due to the competing goals of achieving sufficient decompression, yet mitigating risk to nearby critical neurovascular structures. Transoral approaches have traditionally been avoided for degenerative pseudotumor which generally slowly regresses following posterior fixation. Here, we present two cases of patients with significant retroodontoid degenerative pseudotumor and pannus causing dysphagia and myelopathy. The first patient was found with a large broad pannus requiring a wide decompression extending from lower clivus to inferior aspect of the C1 arch and odontoid process. The second patient had a more focal mass effect due to pannus and synovial cyst at the level of the inferior half of C1 and midodontoid. Both patients underwent an endoscopic endonasal transodontoid approach for immediate decompression followed by a posterior C1–C2 fusion. In these surgical videos, we highlight anatomic considerations in this critical area, demonstrate nuances of technique, and outline strategies to avoid complications and maximize exposure.

The link to the video can be found at: https://youtu.be/19I-GQYGIr4.
Equality prescribed? Contextual determinants of citizens’ support for gender boardroom quotas across Europe
Authors: Möhring Katja , Teney Céline
Published: November 2019

We provide the first cross-national comparative study of citizens’ support for affirmative action policies in the economy using the example of gender quotas for company boards. In contrast to previous studies, we focus on the contextual level and analyse how factors related to political institutions and actors, and economic and social structure shape citizens’ support and the gap in support between men and women. We apply multilevel regression analyses of Eurobarometer data for 27 European countries. Levels of support and gender gaps in support for boardroom quotas vary largely between countries. Contextual factors related to existing quota laws, gender equality in social and economic life, and public opinion towards state intervention are important determinants of cross-national variation. Our results point to an ambiguous relationship of support for gender quotas and actual gender equality in a country. Citizens’ endorsement of quotas is low in countries with high levels of formal gender equality. Support is higher in countries where interventionist policies are widely accepted. Also, existing quota laws are positively related to citizens’ support of boardroom quotas.
A pumpless solution exchange system for nanopore sensors
Authors: Yamada Tetsuya , Kamiya Koki , Osaki Toshihisa , Takeuchi Shoji
Published: November 2019

This paper proposes a nanopore-based sensor exploiting the solution exchange of a droplet-based lipid bilayer driven by a superabsorbent polymer. Biological nanopores are candidates for use in portable sensors because of their potential to recognize and detect single molecules. One of the current challenges in the development of portable nanopore sensors is the inability to achieve continuous detection. To achieve continuous detection, we have exploited the suction force of a superabsorbent polymer to drive the continuous microfluidic flow required to wash the analyte out of the droplet. The superabsorbent polymer drives the microfluidic flow without electricity, and the developed solution exchange system remains compact. To demonstrate solution exchange in the droplet containing the lipid bilayer, the concentration of heptakis(6-O-sulfo)-β-cyclodextrin was monitored in a time-dependent manner using α-hemolysin nanopores. A reduction in the concentration, attributable to solution exchange, was successfully observed. We believe that the proposed system will increase the portability and usability of nanopore sensors.
Gene expression and evidence of coregulation of the production of some metabolites of chilli pepper inoculated with Pectobacterium carotovorum ssp. carotovorum
Authors: Djami-Tchatchou Arnaud Thierry , Matsaunyane Lerato Bame Tsalaemang , Kalu Chimdi Mang , Ntushelo Khayalethu
Published: November 2019

Chilli pepper (Capsicum annuum L.) is susceptible to Pectobacterium carotovorum subsp. carotovorum (Pcc), the causal agent of soft rot disease in crops. Understanding the molecular principles of systemic acquired resistance, which is poorly understood in chilli pepper, represents an important step towards understanding inducible defence responses and can assist in designing appropriate intervention strategies for crop disease management. Accordingly, we investigated (via real-time PCR and metabolomics profiling) the molecular response of chilli pepper to Pcc by characterisation of the crucial metabolic regulators involved in the establishment of defence response. We profiled 13 key inducible defence response genes, which included MYB transcriptor factor, ethylene response element-binding protein, suppressor of the G2 allele of Skp1, cytochrome P450, small Sar1 (GTPase), hydroxycinnamoyl-CoA:quinate hydroxycinnamoyl transferase, pathogenesis-related protein 1a, endo-1,3-β-glucanase, chitinase, proteinase inhibitor, defensin, coiled-coil-nucleotide-binding site-leucine-rich repeat (CC–NBS–LRR) resistance and phenylalanine ammonia lyase. In addition, we determined metabolomic shifts induced by Pcc in pepper. The PCR results revealed a significant induction of the selected plant defence-related genes in response to Pcc inoculation; the metabolomic profiling showed that of 99 primary metabolites profiled the quantities of acetylcarnitine, adenosine, adenosine 3′,5′ cyclic monophosphate, guanosine 3′,5′ cyclic monophosphate and inosine decreased in pepper leaves inoculated with Pcc.
Age and Strengths in a Community Corrections Sample
Authors: Lloyd Caleb D. , Perley-Robertson Bronwen , Serin Ralph C.
Published: November 2019

Variables conceptualized as strengths are theoretically important for the management of recidivism risk among juveniles and adults. Although measures of strengths are related to recidivism outcomes, little is known about whether these factors may vary in prevalence or predictive validity across age. We examined the predictive validity of strengths among male parolees supervised within community corrections ( N = 3,169) rated by supervision officers. The prevalence of strengths did not differ across age. Further, strengths exhibited a promotive effect across all age groups in that predictive validity was consistent across age, with the exception that strength variables were associated with an enhanced promotive effect among older individuals when predicting violent community outcomes. In particular, prosocial relationships were more strongly related to reduced violent recidivism among older compared to younger parolees. Further research is required to identify factors that may have protective or buffering effects among higher risk younger individuals.
Single molecule characterization of individual extracellular vesicles from pancreatic cancer
Authors: Lennon Kathleen M. , Wakefield Devin L. , Maddox Adam L. , Brehove Matthew S. , Willner Ari N. , Garcia‐Mansfield Krystine , Meechoovet Bessie , Reiman Rebecca , Hutchins Elizabeth , Miller Marcia M. , Goel Ajay , Pirrotte Patrick , Van Keuren‐Jensen Kendall , Jovanovic‐Talisman Tijana
Published: November 2019

Biofluid‐accessible extracellular vesicles (EVs) may represent a new means to improve the sensitivity and specificity of detecting disease. However, current methods to isolate EVs encounter challenges when they are used to select specific populations. Moreover, it has been difficult to comprehensively characterize heterogeneous EV populations at the single vesicle level. Here, we robustly assessed heterogeneous EV populations from cultured cell lines via nanoparticle tracking analysis, proteomics, transcriptomics, transmission electron microscopy, and quantitative single molecule localization microscopy (qSMLM). Using qSMLM, we quantified the size and biomarker content of individual EVs. We applied qSMLM to patient plasma samples and identified a pancreatic cancer‐enriched EV population. Our goal is to advance single molecule characterization of EVs for early disease detection.

Abbreviations: EV: Extracellular Vesicle; qSMLM: quantitative Single Molecule Localization Microscopy; PDAC: Pancreatic Ductal Adenocarcinoma; EGFR: epidermal growth factor receptor 1; CA19‐9: carbohydrate antigen 19‐9; SEC: size exclusion chromatography; WGA: wheat germ agglutinin; AF647: Alexa Fluor 647; Ab: antibody; HPDEC: Healthy Pancreatic Ductal Epithelial Cell; TEM: Transmission Electron Microscopy.
Entanglement teleportation via a couple of quantum channels in Ising–Heisenberg spin chain model of a heterotrimetallic Fe–Mn–Cu coordination polymer*
Authors: Zheng Yi-Dan , Mao Zhu , Zhou Bin
Published: November 2019

We investigate the teleportation of an entangled state via a couple of quantum channels, which are composed of a spin-1/2 Heisenberg dimer in two infinite Ising–Heisenberg chains. The heterotrimetallic coordination polymer CuIIMnII(L1)][FeIII(bpb)(CN)2]·ClO4 · H2O (abbreviated as Fe–Mn–Cu) can be regarded as an actual material for this chain. We apply the transfer-matrix approach to obtain the density operator for the Heisenberg dimer and use the standard teleportation protocol to derive the analytical expression of the density matrix of the output state and the average fidelity of the entanglement teleportation. We study the effects of the temperature T, anisotropy coupling parameter Δ, Heisenberg coupling parameter J
2 and external magnetic field h on the quantum channels. The results show that anisotropy coupling Δ and Heisenberg coupling J
2 can favor the generation of the output concurrence and expand the scope of the successful average fidelity.
Capture of material by the protosatellite disks of Jupiter and Saturn
Authors: Kronrod V A , Makalkin A B
Published: November 2019

The problem of passing planetesimals through the accretion disks of Jupiter and Saturn and capture of their material into the disks is considered taking into account processes of aerodynamic braking, fragmentation, and ablation of the bodies in the disk’s gas medium. We have obtained limitations on planetesimal sizes at which the body remains in the protosatellite disk. Estimates are made for the mass of material captured into the disk for the case of power-law mass (and size) distribution of planetesimals. The narrower size range for the captured bodies and longer duration of satellite formation could yield the low differentiation of Callisto as compared with Ganymede. Only minor planetesimals with radii less than 12 m could be captured into the disk of Saturn in the formation region of Titan. This feature promoted significant lengthening of the process of Titan formation.
On Progress in Gravitational Waves Recording
Authors: Gladyshev V O , Fomin I V , Izmailov G N , Morozov A N , Pustovoit VI
Published: November 2019

The paper adduces theoretical data and results of experimental studies confirming the existence of gravitational radiation predicted by the general theory of relativity. It also shows that studying of gravitational waves detection is based on equations of general relativity and equations of electrodynamics, and for modeling of gravitational waves space by sources, equations of hydrodynamics are used.
Fluctuation-dissipation phenomena in the Earth pole oscillations
Authors: Akulenko L D , Pochukaev V N , Perepelkin V V , Filippova A S
Published: November 2019

Earth pole oscillations at the Chandler frequency are studied taking into account nonlinear fluctuation-dissipative moments of forces and disturbances at the Chandler frequency and those close to it. For the stationary mode, the dependence of the external perturbation amplitude at the Chandler frequency on the dissipation coefficients is found. It is shown that the amplitude of the Chandler wobble is sensitive to the difference between the Chandler and close to it frequencies and nonlinear dissipation coefficients.
Application of Baushinger effect during prolonged storage in stressed state of elements of structures made of fiber reinforced plastic
Authors: Sayapin S N , Shkapov P M
Published: November 2019

The problem of the occurrence of irreversible residual deformations is reviewed arising in elements of structures made of carbon fiber reinforced plastic (CFRP) after removing the long and continuous load. These residual deformations impair accuracy of the space structures from CFRP after removing the long load. It is generally known that breaking of the material below the ultimate stress by load cycle reversal in the plastic region is called the Bauschinger effect. Design therefore usually precludes cyclic loading into the plastic region. However, in case of low-cycle loading, the Bauschinger effect can be applied for reduction of the residual deformations in such structures by the pre-loading with opposite sign. CFRP has two plastic deformation stages: the first is ruled by dislocation interactions with the fibers and a real the Bauschinger effect can be observed in repeated tension test. A second stage occurs after 0.6% total strain and is connected with a break of carbon fibers. Examples of the occurrence of residual strain in outer structures from CFRP are shown. A new way of long-term storage in a stressed state of structural elements from CFRP developed on the basis of the Bauschinger effect is presented. The possibility of realization of the proposed method of storage is also shown.
Determination of the associated mass of liquid at vibrations of elastic rod for free surface
Authors: Goncharov D A , Pozhalostin A A
Published: November 2019

In this paper, we consider the problem of free bending vibrations of a rectilinear rod floating on the free surface of a liquid in a rectangular rigid container. This problem is associated with well-known problems, where numerical solutions or asymptotics of the problem of the vibrations of a rod or plates on the free surface of a liquid are considered. On the basis of the accepted assumptions, an exact, analytical solution of this boundary value problem is obtained.
Effect of an upper layer of viscous liquid on breaking surface gravity waves
Authors: Kalinichenko V A
Published: November 2019

The effect of the upper layer of water-immiscible oil on the process of regularization of breaking standing gravity waves on the free surface of a two-layer system in a rectangular vessel has been experimentally investigated for the first time. A comparison is made with the case of standing gravity waves on the free surface of homogeneous liquids (water and seed oil).
Using depth map algorithms to improve the quality of object identification on digital stereo images
Authors: Shkapov P M , Blagoveschensky I G , Petryakov A N , Blagoveschensky V G
Published: November 2019

For the first time experimentally investigated the use of a vision system using the technology of depth maps, infrared depth sensor, laser rangefinder, lidar to determine the relief and geometric dimensions of the object on digital stereo images, which allows continuous monitoring of the state of any process. Methods of digital image processing are presented. The main advantages of such systems are considered.
Designing forward converters for data transmission systems in two-level RNS
Authors: Bergerman M V , Lyakhov P A , Chervyakov N I , Kaplun D I , Bogaevskiy D V
Published: November 2019

We are considering the use of a two-stage Residue number system (RNS) in data transmission systems with a special set of modules {2
l
1
, 2
l
2
, 2
l
3
,…, 2
lp

− 1}. We propose the forward converter with such type of RNS and demonstrate its advantage in hardware costs and delay. This article discusses the FPGA simulation of a forward conversion circuit to a two-stage RNS using adders and the standard modulo function and their comparison in terms of delay and hardware costs.
Modification of ARMA (1, 1) model to simulate strictly stationary random series with uniform distribution
Authors: Garbar S V
Published: November 2019

We consider a problem of simulating strictly stationary random series. A modification of an autoregressive–moving-average model of orders 1, 1 is proposed. Proposed algorithm allows to simulate stationary random series with uniform distribution. Properties of resulting random series are examined.
On Linear Regression and other advanced algorithms for electrical load forecast using weather and time data
Authors: Khadiev K R , Safina L I
Published: November 2019

Energy field plays an important role in commercial world and makes a vital part of humanity. The paper considers the prediction problem concerning spent electrical energy in the Republic of Tatarstan, Russia. In fact, the task of electrical load prediction was set for each hour of the specified period. We solve the problem using Machine learning methods. Four models are considered. These are Linear Regression, Decision Tree, Random Forest and Gradient Tree Boosting. Linear Regression method shows good results, the average relative error is 3.98%. Decision Tree and Random Forest show the worst result, the average relative error is 10.44%. Gradient Tree Boosting show the best result, the average relative error made 2.17%. At the same time, Linear Regression model is much faster than other ones and more useful in industry. In the paper we show that using several techniques we can improve results for Linear Regression, such that it will be close to another advanced algorithms. The average relative error that is less than 5% is considered as a high enough result. The solution of the problem with a small error allows us to prevent the accidents related to electric overload. We assume that load depends on date, time and temperature. Then input variable models were obtained from these data. It is common approach to use that parameters as input data but let us note that the results obtained by other researchers are not suitable for this area, since each area has individual climatic, geological and social features.
On some clarifications of estimates of Lyapunov’s exponents in the method of freezing
Authors: Lasunsky A V
Published: November 2019

Method of V.M. Alekseev was used to obtain the clarifications of lower estimates for the lower singular exponent and of upper estimates for the upper singular exponent of a linear system of differential equations. In contrast to the classical results of the freezing method, which assume that the derivatives of the elements of the matrix of the coefficients of the system are small, the new estimates admit that these derivatives are unbounded.
Calibration of thermal imaging systems based on matrix IR photodetectors
Authors: Petrov M N , Sobolev P S , Cherniak B V
Published: November 2019

The article presents a set of calibration techniques for thermal imaging systems calibration. The proposed algorithms allow high-precision calibration of the IR photodetector with finding and subsequent correction of the entire spectrum of defective pixels: by noise, amplitude and sensitivity. Part of the work is devoted to the development of methods for correcting the influence of ambient temperature on the optical system of a thermal imaging channel, which helps to prevent the effect of super saturation of the IR image pixels.
Mathematical modelling of magnetoelectric effect in multiferroic in thickness-shear mode region
Authors: Petrov V M , Saplev A F , Malyshev O I
Published: November 2019

The article discusses the magnetoelectric effect in the thickness-shear mode region in a layered structure of a piezoelectric bimorph and a magnetostrictive material. Numerical estimates according to the proposed theoretical model of the magnetoelectric effect in the structure of the langatate bimorph and yttrium-iron garnet show that the value of ME voltage coefficient is much higher than for the bilayer of langatate and yttrium-iron garnet.
Effect of electrically induced deformations on ferromagnetic resonance in multiferroic-based heterostructures
Authors: Petrov V M , Saplev A F
Published: November 2019

The paper considers the change in the spectrum of ferromagnetic resonance in ferrite-piezoelectric layered structures in an external electric field. The induced magnetic anisotropy through the magnetoelastic interaction is generally non-uniform in thickness due to the presence of bending deformations. As a result, the applied electric field leads to a shift and broadening of the magnetic resonance line, which are determined by the composition and geometric dimensions of the structure layers. The paper presents a theoretical modeling of the magnetic resonance line broadening when additional buffer layers are inserted between the ferrite and piezoelectric layers to reduce the effect of a high-permittivity piezoelectric on the microwave field structure in the ferrite. The simulation results are considered on the example of layered structures of the composition of iron-yttrium garnet - lead titanate-zirconate. It is shown that at certain thicknesses of the magnetic and piezoelectric layers, the broadening of the magnetic resonance line as a function of the thickness of the buffer layer has a maximum. The results can be used in frequency-selective microwave devices with electrically tunable range.
Calculation of azimuthally currents on the disk
Authors: Sochilin A V , Eminov S I
Published: November 2019

The theory of the integral equation for azimuthal currents in the axisymmetric problem of diffraction on a disk is constructed. The study is based on the selection of the main positive operator. Existence and uniqueness theorems are obtained. An orthonormal basis satisfying the physical condition by Meixner on the edge is constructed. Calculations are made and good convergence of the reduction method is shown.
On the convergence rate of the quasi – Monte Carlo method of search for extremum
Authors: Tikhomirov A S
Published: November 2019

The convergence rate of the quasi – Monte Carlo method of search for extremum is examined. It is shown that, if the objective function is nonsingular, then the number of its evaluations required to obtain the desired accuracy ε in the solution can be a slowly (namely, logarithmically) growing function as ε approaches zero.
Perturbation of Electromagnetic Radiation of Downlink in Orthogonal Components on the GOES 16 Satellite by Planar Antenna Phase Array
Authors: Heilmann A , Tertuliano Filho H. , Dartora C. A. , Clistenes D. , Adams A. M.
Published: November 2019

The Geostationary Operational Environmental Satellite - GOES 16 has an arrangement of planar antennas for uplink and downlink communications in the L-band range, UHF frequency (1694,3/1694,9 MHz), 16 W transmission power and a planar antenna array gain of 28 dBi, for communication operations and data scanning. The structure of antennas in the form of arrangement combines high directivity in the electromagnetic signal and reduction of the broadside, which corresponds to a smaller angular variation. Assuming a communication channel for the GOES 16, from the phase arrangement of planar antennas using 4 rectangular radiant elements of 30 cm × 30 cm (patch) in the transmission (downlink), we defined an expression for the gain of the array of planar antennas and model an acceleration for the satellite, due to the effect of the electromagnetic perturbation it admits, antenna theory and the energy-momentum conservation laws. For a state vector - 04/02/2019, at 18h 40m 12.44s, we implemented a routine using numerical methods with the equation of movement in the form of Cartesian components, which can be used for both keplerian movement as well as adding the desired disturbing accelerations. We propagate its orbit over a period of 5 days, with a step of 10 minutes, and correlate the results of this propagation in the propagated orbital model without disturbance and with the disturbance of the acceleration on the satellite of electromagnetic origin, centered in the phase arrangement of flat antennas. The perturbative effect of this model is applied on GOES 16 taking into account satellite mass, antenna characteristics, radiated power and maximum antenna gain. The numerical integrator used for the solution of the satellite motion equation is based on the fourth and fifth degree Runge-Kutta method, and the results shows that the phase arrangement of planar antennas with the described configuration implies a significant electromagnetic disturbance, changing the components in the direction (radial, transverse and normal) and the coordinates XYZ.
Particle-in-cell numerical simulation of the PHall-IIc Hall thruster
Authors: Braga Leonardo L. , Miranda Rodrigo A.
Published: November 2019

In this work we compare the performance of two types of Hall thrusters, namely, the SPT-100 and the PHall-IIc, the latter being developed by the Plasma Physics Laboratory at the University of Brasilia. The comparison is carried out by performing particle-in-cell simulations. We compute thruster parameters such as thrust and specific impulse. Our results can contribute to the design of electric propulsion devices for future Brazilian space missions.
Orbital maneuvers to form a constellation of small satellites from a single large spacecraft
Authors: Cavalca M P O , Prado A F B A , Gomes V M , Sanchez D M
Published: November 2019

The main goal of the present paper is to show how to form a constellation of small satellites when all small satellites leave from a larger spacecraft. It is assumed that they will all stay in a planar formation, in the same orbital plane of the mother spacecraft, just dispersed in terms of mean anomaly. Initially, it is considered that the larger satellite orbits the Earth in an almost circular orbit with 2000 km of altitude. Then, a search for initial conditions of the small satellite is performed to find the best ones to move it away from the larger satellite such that it is allocated in a co-orbital orbit with respect to the larger satellite. These initial conditions should minimize the consumption of an impulsive maneuver required to move away the small satellite from the large one to put it in course to its final orbit, trying to make the best use of the most relevant perturbations, such as the solar radiation pressure and the oblateness of the Earth. In a second study, we will analyze the influence of the solar radiation pressure, depending on the A/m ratio of the spacecraft, in the trajectories.