bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Infinite Anionic Chains Formed by Alternating Bidentately Acting [SbS4]3‐ Anions and [Mn(dien)]2+ Complexes in the Compound [Mn(dien)]2[Mn(dien)SbS4]2.
Authors: Herzberg Nicola , Naether Christian , Bensch Wolfgang
Published: August 2013

[Mn(dien)2][Mn(dien)SbS4]2 (dien: diethylenetriamine) is synthesized under solvothermal conditions using stoichiometric amounts of Mn, Sb, and S in dien (autoclave, 140 °C, 2 d, 5—15% yield).
ChemInform Abstract: Synthesis, Structure, and Optical Properties of the Quaternary Diamond‐Like Compounds I2—II—IV—VI4 (I: Cu; II: Mg; IV: Si, Ge; VI: S, Se).
Authors: Liu Bin‐Wen , Zhang Ming‐Jian , Zhao Zhong‐Yan , Zeng Hui‐Yi , Zheng Fa‐Kun , Guo Guo‐Cong , Huang Jin‐Shun
Published: August 2013

Cu2MgSiS4 (I), Cu2MgGeS4 (II), and Cu2MgSiSe4 (III) are synthesized by solid state reactions of stoichiometric mixtures of the elements (quartz tube, 950 °C, 5 d).
ChemInform Abstract: Batch to Flow Deoxygenation Using Visible Light Photoredox Catalysis.
Authors: Nguyen John D. , Reiss Barbara , Dai Chunhui , Stephenson Corey R. J.
Published: August 2013

A catalytic one‐pot deoxygenation protocol for primary and secondary alcohols (I) that shows high functional group tolerance is developed.
ChemInform Abstract: Synthesis of Z‐(Pinacolato)allylboron and Z‐(Pinacolato)alkenylboron Compounds Through Stereoselective Catalytic Cross‐Metathesis.
Authors: Kiesewetter Elizabeth T. , O'Brien Robert V. , Yu Elsie C. , Meek Simon J. , Schrock Richard R. , Hoveyda Amir H.
Published: August 2013

The authors describe three catalysts for the Z‐selective cross‐metathesis of allyl‐ and alkenylboron substrates.
ChemInform Abstract: Gold(I)‐Catalyzed Direct Allylic Etherification of Unactivated Alcohols.
Authors: Young Paul C. , Schopf Nina A. , Lee Ai‐Lan
Published: August 2013

A regio‐ and stereoselective Au(I)‐catalyzed direct allylic etherification of allylic alcohols, such as (I), (IV), (VII), and (X) is reported.
ChemInform Abstract: A New Photoclick Reaction Strategy: Photo‐Induced Catalysis of the Thiol‐Michael Addition via a Caged Primary Amine.
Authors: Xi Weixian , Krieger Matthias , Kloxin Christopher J. , Bowman Christopher N.
Published: August 2013

The utilization of 2‐(2‐nitrophenyl)propyloxycarbonyl as a photolabile primary amine cage enables the thiol‐Michael ′click′ reaction to be photo‐triggered.
ChemInform Abstract: Electrochemical Thiocyanation of Nitrogen‐Containing Aromatic and Heteroaromatic Compounds.
Authors: Fotouhi Lida , Nikoofar Kobra
Published: August 2013

Thiocyanogen is electrochemically generated in situ and subjected to reactions with nitrogen‐containing arenes.
ChemInform Abstract: Arene CH—O Hydrogen Bonding: A Stereocontrolling Tool in Palladium‐Catalyzed Arylation and Vinylation of Ketones.
Authors: Huang Zhiyan , Lim Li Hui , Chen Zuliang , Li Yongxin , Zhou Feng , Su Haibin , Zhou Jianrong
Published: August 2013

Different enol acetates are treated with aryl and vinyl triflates as well as aryl halides in the presence of chiral phenoxy‐substituted ligands (I).
ChemInform Abstract: Superbase‐Promoted Selective Cascade Cyclization Reaction of 1,5‐Diketones with Acetylenes to Methylene‐6,8‐dioxabicyclo[3.2.1]octanes.
Authors: Schmidt Elena Yu. , Bidusenko Ivan A. , Protsuk Nadezhda I. , Ushakov Igor A. , Trofimov Boris A.
Published: August 2013

A new stereoselective and transition metal‐free one‐pot cascade cyclization reaction for the synthesis of different substituted bicyclooctanes is developed.
ChemInform Abstract: Ready Synthetic Access to Enantiopure Allylic α(F)‐Branched Fluoroalkenes.
Authors: Larnaud Florent , Malassis Julien , Pfund Emmanuel , Linclau Bruno , Lequeux Thiery
Published: August 2013

For the first time synthesis of homochiral α‐fluorinated benzothiazolyl sulfones (X) with a chiral center in the β‐position is achieved via a Julia‐Kocienski olefination followed by modified Mitsunobu reaction.
ChemInform Abstract: Studies on Reactions of Anhydrides with Schiff Bases.
Authors: Kumar Padam Praveen , Mohiuddin S. M. G. , Devi B. Rama , Dubey P. K.
Published: August 2013

Imides (III) are synthesized via title reaction.
ChemInform Abstract: Pd‐Catalyzed Suzuki—Miyaura Cross‐Coupling Reactions Between Sulfamates and Potassium Boc‐Protected Aminomethyltrifluoroborates.
Authors: Molander Gary A. , Shin Inji
Published: August 2013

The amount of base is not general and has to be optimized for each case.
ChemInform Abstract: Electrochemical C—H Amination: Synthesis of Aromatic Primary Amines via N‐Arylpyridinium Ions.
Authors: Morofuji Tatsuya , Shimizu Akihiro , Yoshida Jun‐ichi
Published: August 2013

The synthetic value of this method is demonstrated by a short preparation of compound (XIX) which is a key intermediate in the synthesis of a VLA‐4 antagonist.
ChemInform Abstract: An Efficient and Recyclable Catalyst for N‐Alkylation of Amines and β‐Alkylation of Secondary Alcohols with Primary Alcohols: SBA‐15 Supported N‐Heterocyclic Carbene Iridium Complex.
Authors: Wang Dong , Guo Xu‐Qing , Wang Chen‐Xi , Wang Ya‐Nong , Zhong Rui , Zhu Xiao‐Han , Cai Li‐Hua , Gao Zi‐Wei , Hou Xiu‐Feng
Published: August 2013

The catalyst can be recovered by simple filtration and reused eight or twelve times (β‐alkylation resp.
ChemInform Abstract: Formal γ‐Alkynylation of Ketones via Pd‐Catalyzed C—C Cleavage.
Authors: Ziadi Asraa , Correa Arkaitz , Martin Ruben
Published: August 2013

The presented method allows for the coupling of tert‐cyclobutanols, such as (I) and (VI) with bromoacetylenes, giving access to versatile alkynes (III) and (VIII), respectively.
ChemInform Abstract: An Odorless, One‐Pot Synthesis of Thioesters from Organic Halides, Thiourea and Benzoyl Chlorides in Water.
Authors: Lu Guo‐ping , Cai Chun
Published: August 2013

Thioester formation is achieved in a one‐pot, three‐component reaction via in situ generated S‐alkylisothiouronium salts.
ChemInform Abstract: Synthesis of Sulfonic Acid Derivatives by Oxidative Deprotection of Thiols Using tert‐Butyl Hypochlorite.
Authors: Joyard Yoann , Papamicael Cyril , Bohn Pierre , Bischoff Laurent
Published: August 2013

One‐pot procedure is developed by generation of thioacetates in situ, followed by oxidation with tBuOCl leading to sulfonyl chlorides and trapping with electrophiles as amine, alcohol or water.
ChemInform Abstract: Nickel‐Catalyzed Suzuki—Miyaura Coupling of Heteroaryl Ethers with Arylboronic Acids.
Authors: Li Xiao‐Jian , Zhang Jin‐Ling , Geng Yu , Jin Zhong
Published: August 2013

Heteroaryl ethers of type (III) are found to be efficient substrates in Ni‐catalyzed Suzuki—Miyaura coupling reaction giving a wide range of biaryls in good to high yields.
ChemInform Abstract: Stereoselective Synthesis of Aminoindanols via an Efficient Cascade Aza‐Michael—Aldol Reaction.
Authors: Qian Hui , Zhao Wanxiang , Sung Herman H.‐Y. , Williams Ian D. , Sun Jianwei
Published: August 2013

An organocatalytic diastereoselective synthesis of 3‐amino‐1‐indanols (III) and (V), a privileged skeleton of significant importance in organic synthesis and medicinal chemistry, is described.
ChemInform Abstract: Low‐Cost Synthesis of Fullerene Derivatives
Authors: Chountoulesi Eleni , Mitzithra Christine , Hamilakis Stylianos , Kordatos Konstantinos , Kollia Constantina , Loizos Zaphirios
Published: August 2013

using refined mixed fullerenes instead of pure C60 as starting material
ChemInform Abstract: Synthesis of Optically Enriched Spirocyclic Benzofuran‐2‐ones by Bifunctional Thiourea‐Base Catalyzed Double‐Michael Addition of Benzofuran‐2‐ones to Dienones.
Authors: Li Xin , Yang Chen , Jin Jia‐Lu , Xue Xiao‐Song , Cheng Jin‐Pei
Published: August 2013

The reaction proceeds with moderate to high dia‐ and high enantioselectivities for the symmetrical and unsymmetrical diaryldienones.
ChemInform Abstract: Stille Coupling of an Aziridinyl Stannatrane.
Authors: Theddu Naresh , Vedejs Edwin
Published: August 2013

Under modified Stille conditions the stannatrane (I) is found to undergo efficient coupling with aryl and alkenyl halides to afford various functionalized aziridines.
ChemInform Abstract: Donor—Acceptor Cyclopropanes with Lawesson′s and Woollins′ Reagents: Formation of Bisthiophenes and Unprecedented Cage‐Like Molecules.
Authors: Kaschel Johannes , Schmidt Christian D. , Mumby Mark , Kratzert Daniel , Stalke Dietmar , Werz Daniel B.
Published: August 2013

Furan‐derived donor—acceptor‐substituted cyclopropanes (I) react with Lawesson reagent to furnish either bisthiophenes (II) or unprecedented cagelike molecules (V) depending on the reaction conditions.
ChemInform Abstract: An Efficient and Convenient Synthesis of 1,2,3‐Trisubstituted Pyrroles via Iodocyclization from Ethyl Acetoacetate.
Authors: Xu Pengfei , Huang Kunzhu , Liu Zhiguo , Zhou Ming , Zeng Wenbin
Published: August 2013

A three‐component, two‐step procedure offers a direct synthesis of the target compounds via iodocyclization of β‐enaminone intermediates.
ChemInform Abstract: Design, Synthesis, and Evaluation of 3‐Aryl‐4‐pyrrolylmaleimides as Glycogen Synthase Kinase‐3β Inhibitors.
Authors: Ye Qing , Li Meng , Zhou Yu‐Bo , Cao Jia‐Yu , Xu Lei , Li Yu‐Jin , Han Liang , Gao Jian‐Rong , Hu Yong‐Zhou , Li Jia
Published: August 2013

New title compounds (IIIa)—(IIIe) significantly reduce Aβ‐induced Tau hyperphosphorylation, and show inhibition of GSK‐3β at the cellular level.
ChemInform Abstract: Application of in situ‐Generated Rh‐Bound Trimethylenemethane Variants to the Synthesis of 3,4‐Fused Pyrroles.
Authors: Schultz Erica E. , Sarpong Richmond
Published: August 2013

The utility of this method is demonstrated by a synthesis of cycloprodigiosin (IX).
ChemInform Abstract: Copper‐Catalyzed Selective Oxidative Acylation of Secondary Anilines with Ethyl Glyoxalate: Domino Synthesis of Indoline‐2,3‐diones.
Authors: Liu Tao , Yang Haijun , Jiang Yuyang , Fu Hua
Published: August 2013

When unsymmetrical diarylamines are used as substrates, the aryl group containing electron‐rich substituents is favored for the reaction.
ChemInform Abstract: Synthesis of 3‐(1H‐Benzo[d]imidazol‐1‐yl)isoindolin‐1‐one Derivatives Promoted by EtOH—AcOH Solvent System.
Authors: You Hanyun , Chen Fanglei , Lei Min , Hu Lihong
Published: August 2013

The method allows a simple and efficient approach to various pharmaceutically interesting isoindole systems.
ChemInform Abstract: [Cu30I16(mtpmt)12 (μ10‐S4)]: An Unusual 30‐Membered Copper(I) Cluster Derived from the C—S Bond Cleavage and Its Use in Heterogeneous Catalysis.
Authors: Li Hong‐Xi , Zhao Wei , Li Hai‐Yan , Xu Zhong‐Lin , Wang Wen‐Xia , Lang Jian‐Ping
Published: August 2013

The Cu(I)‐mediated C—S bond cleavage of 5‐methyl‐4‐tolylpyrimidine‐2‐thiol (mtpmth) affords the title complex, which exhibits high catalytic activity in the coupling reactions of N‐heterocycles, e.g. (I) and (IV), and arylboronic acids (II) and (V).
ChemInform Abstract: Base‐Catalyzed Cyclization of N‐Sulfonyl Propargylamides to Sulfonylmethyl‐Substituted Oxazoles via Sulfonyl Migration.
Authors: Yu Xinzhang , Xin Xiaoyi , Wan Boshun , Li Xingwei
Published: August 2013

The oxazoles are obtained in high selectivity via 1,4‐sulfonyl migration.
ChemInform Abstract: Iodine(III)‐Promoted Synthesis of Oxazolines from N‐Allylamides.
Authors: Moon Nicholas G. , Harned Andrew M.
Published: August 2013

Cyclization of N‐allylamides (I) in the presence of acetic acid is mediated by hypervalent iodine and results in a moderately efficient synthesis of 2,5‐disubstituted oxazolines.
ChemInform Abstract: Enantioselective Aza‐Henry Reaction of Imines Bearing a Benzothiazole Moiety Catalyzed by a Cinchona‐Based Squaramide.
Authors: He Hai‐Xiao , Yang Wen , Du Da‐Ming
Published: August 2013

This method can be used with imine substrates or as a multicomponent reaction with in situ generated imines.
ChemInform Abstract: Fused Polycyclic Compounds via Cycloaddition of 4‐(1′‐Cyclohexenyl)‐5‐iodo‐1,2,3‐triazoles with 4‐Phenyl‐1,2,4‐triazoline‐3,5‐dione: The Importance of a Sacrificial Iodide Leaving Group.
Authors: Michaels Heather A. , Simmons J. Tyler , Clark Ronald J. , Zhu Lei
Published: August 2013

It is found that coupling of 5‐iodo‐1,2,3‐triazoles of type (I) with the triazolinedione (II) allows formation of polycyclic triazoles like (III).
ChemInform Abstract: Pd‐Catalyzed Allylic Alkylation Cascade with Dihydropyrans: Regioselective Synthesis of Furo[3,2‐c]pyrans.
Authors: Bartlett Mark J. , Turner Claire A. , Harvey Joanne E.
Published: August 2013

A Pd‐catalyzed allylic alkylation cascade of cyclic β‐dicarbonyl bis‐nucleophiles with nonsymmetric pyran‐based bis‐electrophiles is used to prepare a variety of cis‐fused furo[3,2‐c]pyrans in high regio‐ and stereoselectivity.
ChemInform Abstract: Enantioselective Synthesis of 4‐Substituted Dihydrocoumarins Through a Zinc Bis(hydroxyamide)‐Catalyzed Conjugate Addition of Terminal Alkynes.
Authors: Blay Gonzalo , Munoz M. Carmen , Pedro Jose R. , Sanz‐Marco Amparo
Published: August 2013

Terminal alkynes (II) react with coumarins (I) in the presence of diethylzinc and chiral bis(hydroxyamide) ligands to give enantiopure dihydrocoumarins (III) substituted with an alkynyl group in C(4) position in good enantioselectivities.
ChemInform Abstract: Thermally Controlled Decarboxylative [4 + 2] Cycloaddition Between Alkoxyoxazoles and Acrylic Acid: Expedient Access to 3‐Hydroxypyridines.
Authors: Jouanno Laurie‐Anne , Tognetti Vincent , Joubert Laurent , Sabot Cyrille , Renard Pierre‐Yves
Published: August 2013

The reaction allows the selective formation of 3‐hydroxypyridines.
ChemInform Abstract: Pericyclic Rearrangements of N‐Heterocyclic Carbenes of Indazole to Substituted 9‐Aminoacridines.
Authors: Guan Zong , Wiechmann Sascha , Drafz Martin , Huebner Eike , Schmidt Andreas
Published: August 2013

A novel synthesis of new acridines via rearrangement of in situ generated indazol‐3‐ylidenes is developed.
ChemInform Abstract: Highly Enantioselective Rhodium‐Catalyzed [2 + 2 + 2] Cycloaddition of Diynes to Sulfonimines.
Authors: Amatore Muriel , Leboeuf David , Malacria Max , Gandon Vincent , Aubert Corinne
Published: August 2013

This is the first asymmetric transition‐metal‐catalyzed [2+2+2] cycloaddition of diynes to sulfonimines.
ChemInform Abstract: Direct Conversion of 1‐(2‐Bromobenzoyl)isoquinolines to Dibenzo[de,g]quinolin‐7‐ones via Reductive Photocyclization.
Authors: Chuang Ta‐Hsien , Li Chien‐Fu , Lee Hong‐Zin , Wen Yu‐Chia
Published: August 2013

A convenient and new one‐pot method for the synthesis of tetracyclic alkaloids is presented via reductive photocyclization.
ChemInform Abstract: Unprecedented Construction of C=C Double Bonds via Ir‐Catalyzed Dehydrogenative and Dehydrative Cross‐Couplings.
Authors: Nie Shao‐zhen , Sun Xiang , Wei Wen‐tao , Zhang Xue‐jing , Yan Ming , Xiao Jian‐liang
Published: August 2013

Since the dehydrogenation proceeds separately after the coupling reaction longer reaction times are required to avoid a product mixture.
ChemInform Abstract: Iron(III)‐Catalyzed Cascade Reaction Between Nitroolefins and 2‐Aminopyridines: Synthesis of Imidazo[1,2‐a]pyridines and Easy Access Towards Zolimidine.
Authors: Santra Sougata , Bagdi Avik Kumar , Majee Adinath , Hajra Alakananda
Published: August 2013

Derivative (IIIe) can be further oxidized to afford zolimidine (IV), a useful drug for the treatment of peptic ulcer.
ChemInform Abstract: A Copper‐Catalyzed Aerobic Cascade Dehydrogenative—Dehalogenative Reaction
Authors: Liang Lei , Yang Guanyu , Wang Wei , Xu Fengrong , Niu Yan , Sun Qi , Xu Ping
Published: August 2013

of halogenated 6‐aryl‐4,5‐dihydropyridazinones using a catalytic system consisting of Cu(OAc)2/Na2CO3/pyridine with oxygen as the terminal oxidant
ChemInform Abstract: Ureas/Thioureas of Benzo[d]isothiazole Analogue Conjugated Glutamic Acid: Synthesis and Biological Evaluation.
Authors: Sharma Anamika , Suhas Ramesh , Gowda Dase Channe
Published: August 2013

Compounds (VII) possess good antiglycation and urease inhibitory activities greater than the reference standards rutin and thiourea.
ChemInform Abstract: Synthesis and Biological Evaluation of Some 1,2‐Disubstituted Benzimidazole Derivatives as New Potential Anticancer Agents.
Authors: Yurttas Leyla , Demirayak Seref , Ciftci Guelsen A. , Yildirim Safak Ulusoylar , Kaplancikli Zafer A.
Published: August 2013

Most of the synthesized title compounds (V) (16 examples), especially derivatives (Va)—(Vc), exhibit considerable activity and selectivity against C6 and MCF‐7 cancer cell lines.
ChemInform Abstract: Antimicrobial Evaluation of Some Novel Isoxazoles, Cyanopyridines and Pyrimidinthiones.
Authors: Solankee Anjani , Patel Kirti , Patel Rajnikant
Published: August 2013

The title compounds are screened for their antibacterial activity against Gram negative (E.
ChemInform Abstract: An Efficient One‐Pot Microwave Assisted Synthesis of Dibenzoazepinones.
Authors: Deb Prasant K. , Sharma Somesh , Borude Avinash , Singh Ravi P. , Kumar Deepak , Reddy L. Krishnakanth
Published: August 2013

The Suzuki coupling of 2‐(2‐bromophenyl)acetic esters with 2‐aminophenyl boronates is found to be optimal in the sequence A) + B) or in the one‐step process C).
ChemInform Abstract: Enantioselective Trapping of Phosphoramidate Ammonium Ylides with Imino Esters for Synthesis of 2,3‐Diaminosuccinic Acid Derivatives.
Authors: Jiang Jun , Ma Xiaochu , Liu Shunying , Qian Yu , Lv Fengping , Qiu Lin , Wu Xiang , Hu Wenhao
Published: August 2013

The rhodium acetate and chiral Broensted acid co‐catalyzed three‐component Mannich‐type reaction of a diazo compound (I), a phosphoramidite (II), and an α‐imino ester (III) provides an efficient access to title compounds (IV) with high levels of diastereo‐ and enantioselectivity.
ChemInform Abstract: Synthesis, Structure and Reactivity of Cyclopropenyl‐1‐ylidene Stabilized S(II), Se(II) and Te(II) Mono‐ and Dications.
Authors: Kozma Agnes , Petuskova Jekaterina , Lehmann Christian W. , Alcarazo Manuel
Published: August 2013

Syntheses and structural characterization of carbene‐stabilized chalcogen centered mono‐ and dications (III) and (IV) employing a reverse electron demand onio‐substituent transfer strategy are reported.
ChemInform Abstract: Hydrometalation‐Asymmetric Conjugate Addition: Application to Complex Molecule Synthesis.
Authors: Maksymowicz Rebecca M. , Roth Philippe M. C. , Thompson Amber L. , Fletcher Stephen P.
Published: August 2013

Cu‐catalysis allows alkyl zirconium species, generated in situ from alkenes, to undergo conjugate addition reactions.
ChemInform Abstract: SmI2‐Mediated Couplings of α‐Amino Acid Derivatives. Formal Synthesis of (—)‐Pumiliotoxin 251D and (.+‐.)‐Epiquinamide.
Authors: Pinho Vagner D. , Procter David J. , Burtolosco Antonio C. B.
Published: August 2013

A straightforward approach for the construction of hydroxylated indolizidine, quinolizidine and piperidine systems via highly diastereoselective SmI2‐mediated coupling reactions of α‐amino acid derivatives with methyl acrylate is developed.
ChemInform Abstract: Rapid Synthesis of Oligomannosides with Orthogonally Protected Monosaccharides.
Authors: Chang Sue‐Ming , Tu Zhijay , Jan Hau‐Ming , Pan Jia‐Fu , Lin Chun‐Hung
Published: August 2013

A consecutive synthetic procedure to synthesize orthogonally protected mannose building blocks is described.
ChemInform Abstract: Organocatalyzed Asymmetric Synthesis of Morphans.
Authors: Bradshaw Ben , Parra Claudio , Bonjoch Josep
Published: August 2013

For the first time an effective organocatalytic synthesis of polyfunctionalized enantiopure morphans is developed.
ChemInform Abstract: Titanium Silicide Nanonet as a New Material Platform for Advanced Lithium Ion Battery Applications
Authors: Zhou Sa , Yang Xiaogang , Xie Jin , Simpson Zachary I. , Wang Dunwei
Published: August 2013

Review: 62 refs.
ChemInform Abstract: Ubiquitous Trisulfur Radical Anion: Fundamentals and Applications in Materials Science, Electrochemistry, Analytical Chemistry and Geochemistry
Authors: Chivers Tristram , Elder Philip J. W.
Published: August 2013

Review: 50 refs.
ChemInform Abstract: Emerging Strategies for the Total Synthesis of Inorganic Nanostructures
Authors: Buck Matthew R. , Schaak Raymond E.
Published: August 2013

Review: 197 refs.
ChemInform Abstract: Metal‐Cation‐Directed Synthesis, Structures, and Optical Properties of Mo(W)/S(Se)/Ag Clusters: A Brief Overview
Authors: Li Jianghua , Zhang Jinfang , Humphrey Mark G. , Zhang Chi
Published: August 2013

Review: 38 refs.
ChemInform Abstract: Recent Developments of Atomic Layer Deposition Processes for Metallization
Authors: Li Wei‐Min
Published: August 2013

Review: 172 refs.
ChemInform Abstract: The Templating Effect and Photochemistry of Viologens in Halometalate Hybrid Crystals
Authors: Mercier Nicolas
Published: August 2013

Review: structure, electric and photochromic properties; 52 refs.
ChemInform Abstract: Supramolecular Compounds Through Coordination Chemistry. Basic Strategies
Authors: Bartkowiak Grazyna , Gawron Katarzyna , Schroeder Grzegorz
Published: August 2013

Review: 47 refs.
ChemInform Abstract: Quinoxaline‐Based Schiff Base Transition Metal Complexes: Review
Authors: Dhanaraj Chellaian Justin , Johnson Jijo , Joseph Jeyasekaran , Joseyphus Raphael Selwin
Published: August 2013

Review: synthesis, spectral, structural characterization, and biological activities; 9 refs.
ChemInform Abstract: Cyclodextrins and Calix[n]arenes as Inverse Phase Transfer Catalysts
Authors: Anishchenko Viktor , Rybachenko Volodymyr , Schroeder Grzegorz , Chotiy Konstantine , Redko Andrey
Published: August 2013

Review: 27 refs.
ChemInform Abstract: Ionic Liquids Derived from Natural Sources
Authors: Kagimoto Junko , Ohno Hiroyuki
Published: August 2013

Review: 38 refs.
ChemInform Abstract: Active Species of Nonheme Iron and Manganese‐Catalyzed Oxidations
Authors: Lyakin Oleg Y. , Ottenbacher Roman V. , Bryliakov Konstantin P. , Talsi Evgenii P.
Published: August 2013

Review: 93 refs.
ChemInform Abstract: Some Recent Approaches in the Design of Synthetic Antitubercular Agents Containing Five‐Membered Heterocyclic Rings
Authors: Asif Mohammad
Published: August 2013

Review: 216 refs.
ChemInform Abstract: Lipid‐Inspired Ionic Liquids Containing Long‐Chain Appendages: Novel Class of Biomaterials with Attractive Properties and Applications
Authors: Mirjafari Arsalan , O'Brien Richard A. , Murray Samuel M. , Mattson Kaila M. , Mobarrez Niloufar , West Kevin N. , Davis, James H. Jr.
Published: August 2013

Review: 40 refs.
ChemInform Abstract: Marine Natural Products: Synthetic Aspects
Authors: Morris Jonathan C.
Published: August 2013

Review: 154 refs.
ChemInform Abstract: Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
Authors: Prier Christopher K. , Rankic Danica A. , MacMillan David W. C.
Published: August 2013

Review: 291 refs.
ChemInform Abstract: Diverse Transformations of Chiral Propargylic Alcohols Generated by BINOL‐Catalyzed Alkyne Addition to Aldehydes
Authors: Wang Qin , Pu Lin
Published: August 2013

Review: 35 refs.
ChemInform Abstract: Design and Synthesis of Chiral Spiro Ligands
Authors: Bajracharya Gan B.
Published: August 2013

Review: 96 refs.
ChemInform Abstract: General Aspects of Isocyanide Reactivity
Authors: Mironov Maxim A.
Published: August 2013

Review: 129 refs.
ChemInform Abstract: Allenamides: A Powerful and Versatile Building Block in Organic Synthesis
Authors: Lu Ting , Lu Zhenjie , Ma Zhi‐Xiong , Zhang Yu , Hsung Richard P.
Published: August 2013

Review: 229 refs.
ChemInform Abstract: Recent Developments in Catalytic Asymmetric Inverse Electron Demand Diels—Alder Reaction
Authors: Jiang Xianxing , Wang Rui
Published: August 2013

Review: 294 refs.
ChemInform Abstract: Marine Indole Alkaloids Containing an 1‐(Indol‐3‐yl)ethane‐1,2‐diamine Fragment
Authors: Golantsov N. E. , Festa A. A. , Karchava A. V. , Yurovskaya M. A.
Published: August 2013

Review: isolation, synthesis and biological properties; 82 refs.
ChemInform Abstract: Magnetic Resonance Spectroscopy: Singlet and Doublet Electronic States
Authors: Pedone Alfonso , Crescenzi Orlando
Published: August 2013

Review: 143 refs.
ChemInform Abstract: C—C Hydrolases for Biocatalysis.
Authors: Siirola Elina , Frank Annika , Grogan Gideon , Kroutil Wolfgang
Published: August 2013

Review: 64 refs.
ChemInform Abstract: Fiber‐Optical Sensors: Basics and Applications in Multiphase Reactors
Authors: Li Xiangyang , Yang Chao , Yang Shifang , Li Guozheng
Published: August 2013

Review: 136 refs.
ChemInform Abstract: Introduction to Catalysis: Mechanisms and Industrial Applications
Authors: Guisnet Michel
Published: August 2013

Review: 37 refs.
ChemInform Abstract: Liquisolid Technology
Authors: Pathak Ashish , Goyal Rajkumar , Agrawal Preeti , Rajput Sarlesh , Tiwari Gourav , Shivhare Rituraj
Published: August 2013

Review: 35 refs.
ChemInform Abstract: Chemical Preconversion: Application of Low‐Severity Pretreatment Chemistries for Commoditization of Lignocellulosic Feedstock
Authors: Thompson David N. , Campbell Timothy , Bals Bryan , Runge Troy , Teymouri Farzaneh , Ovard Leslie Park
Published: August 2013

Review: 114 refs.
ChemInform Abstract: Kinetics in Homogeneous Catalysis
Authors: Heller Detlef
Published: August 2013

Review: 42 refs.
ChemInform Abstract: Recent Progress in Luminescent and Colorimetric Chemosensors for Detection of Thiols
Authors: Jung Hyo Sung , Chen Xiaoqiang , Kim Jong Seung , Yoon Juyoung
Published: August 2013

Review: 50 refs.
Various Polar Tripeptides as Asymmetric Organocatalyst in Direct Aldol Reactions in Aqueous Media
Authors: Bayat Saadi , Tejo Bimo A. , Salleh Abu Bakar , Abdmalek Emilia , Normi Yahaya M. , Rahman Mohd Basyaruddin Abdul
Published: August 2013

A series of tripeptide organocatalysts containing a secondary amine group and two amino acids with polar side chain units were developed and evaluated in the direct asymmetric intermolecular aldol reaction of 4‐nitrobenzaldehyde and cyclohexanone. The effectiveness of short polar peptides as asymmetric catalysts in aldol reactions to attain high yields of enantio‐ and diastereoselective isomers were investigated. In a comparison, glutamic acid and histidine produced higher % ee and yields when they were applied as the second amino acid in short trimeric peptides. These short polar peptides were found to be efficient organocatalysts for the asymmetric aldol addition reaction in aqueous media. Chirality 25:726–734, 2013. © 2013 Wiley Periodicals, Inc
Crystallographic, Spectroscopic, and Theoretical Investigation of the Efficiently Separated 21R and 21S‐Diastereoisomers of Argatroban
Authors: Ferraboschi Patrizia , Colombo Diego , Legnani Laura , Toma Lucio , Grisenti Paride , Vistoli Giulio , Meneghetti Fiorella
Published: August 2013

Argatroban (I), a potent noncovalent reversible thrombin inhibitor, is used as an anticoagulant for the parenteral treatment of heparin‐induced thrombocytopenia (HIT) patients. By virtue of its pharmacological properties and the well‐balanced risks and benefits, argatroban is now emerging as a clinically relevant antithrombotic agent. The availability of this drug as a mixture of 21R and 21S‐diastereoisomers, in a ratio of roughly 64:36, prompted us to design an efficient separation setup of the two epimers. We pursued our efforts on their detailed structural analysis with the aim of understanding their different activity and aqueous solubility. These investigations were accompanied by a modeling study of the two diastereoisomers, with particular attention on the easy interconverting half‐chair of the tetrahydroquinoline system and its preferred conformation, which is determined by the configuration at C21. These results, together with the analysis of their physicochemical profiles, provide new useful information for the development of the individual diastereoisomers. Chirality 25:871–882, 2013. © 2013 Wiley Periodicals, Inc.
Corrosion behaviour of steel/55%Al–Zn alloy/paint systems exposed to natural and artificial environments
Authors: Elsner Cecilia I. , del Amo Delia B. , Hernández Luis S. , Di Sarli Alejandro R.
Published: August 2013

The corrosion performance of steel/55%Al–Zn alloy sheets pre‐treated with 5% Fe (NO3)3 + 15% H3PO4solution, and then coated with acrylic (AC), alkyd (AQ), vinyl (VL), solvent‐based epoxy (ES) or waterborne epoxy (EA) corrosion‐inhibiting primers + a barrier topcoat alkyd paint was studied. Exposure conditions included weathering chambers and natural atmospheres (La Plata‐Argentina and San Luis‐Potosí, México). The panels' behaviour was evaluated through visual inspections and EIS measurements. Their results allowed inferring that: (1) most of the painting systems have a satisfactory performance during their exposure to the accelerated weathering chamber or the natural atmospheric stations and (2) the correlation between them allowed explaining some problems arising in service. This information will allow extending the useful life by adjusting the painting system formulation.
Nanostructures of Nematic Materials of Laterally Branched Molecules
Authors: Breckon Randall , Chakraborty Saonti , Zhang Cuiyu , Diorio Nicholas , Gleeson James T. , Sprunt Samuel , Twieg Robert J. , Jákli Antal
Published: August 2013

The synthesis and small‐angle X‐ray scattering (SAXS) characterization is reported for 20 laterally branched mesogenic molecules, which are derived from the common rod‐shaped 2,5‐bis([4‐(octyloxy)phenyl]carbonyloxy) benzoic acid unit. These compounds have a varying degree of flexibility, in that their lateral branch is formed upon conversion of the acid to either an ester or an amide, and most laterally branched molecules exhibit relatively wide nematic liquid‐crystal phases with a direct nematic‐to‐crystal transition at lower temperatures. SAXS studies reveal the presence of smectic‐like nanostructures (clusters) with short‐range order in the nematic phase, with characteristic correlation lengths from 3 to over 10 nm. The smectic layers that are contained in these clusters are tilted with respect to the nematic director by angles ranging from 0° (i.e. untilted) to 55°. In some compounds, the intensity of the SAXS peak corresponding to the smectic layer spacing depends strongly on temperature. The main features of the nanostructures can be understood based on the molecular structure; therefore, guiding future synthetic work towards more precisely controlled and technologically useful nanostructures in nematics.
Dehydration of Different Ketoses and Aldoses to 5‐Hydroxymethylfurfural
Authors: van Putten Robert‐Jan , Soetedjo Jenny N. M. , Pidko Evgeny A. , van der Waal Jan C. , Hensen Emiel J. M. , de Jong Ed , Heeres Hero J.
Published: August 2013

5‐Hydroxymethylfurfural (HMF) is considered an important building block for future bio‐based chemicals. Here, we present an experimental study using different ketoses (fructose, sorbose, tagatose) and aldoses (glucose, mannose, galactose) under aqueous acidic conditions (65 g L−1 substrate, 100–160 °C, 33–300 mM H2SO4) to gain insights into reaction pathways for hexose dehydration to HMF. Both reaction rates and HMF selectivities were significantly higher for ketoses than for aldoses, which is in line with literature. Screening and kinetic experiments showed that the reactivity of the different ketoses is a function of the hydroxyl group orientation at the C3 and C4 positions. These results, in combination with DFT calculations, point to a dehydration mechanism involving cyclic intermediates. For aldoses, no influence of the hydroxyl group orientation was observed, indicating a different rate‐determining step. The combination of the knowledge from the literature and the findings in this work indicates that aldoses require an isomerization to ketose prior to dehydration to obtain high HMF yields.
Sweeping beauty: is grassland arthropod community composition effectively estimated by sweep netting?
Authors: Spafford Ryan D. , Lortie Christopher J.
Published: August 2013

Arthropods are critical ecosystem components due to their high diversity and sensitivity to perturbation. Furthermore, due to their ease of capture they are often the focus of environmental health surveys. There is much debate regarding the best sampling method to use in these surveys. Sweep netting and pan trapping are two sampling methods commonly used in agricultural arthropod surveys, but have not been contrasted in natural grassland systems at the community level. The purpose of this study was to determine whether sweep netting was effective at estimating arthropod diversity at the community level in grasslands or if supplemental pan trapping was needed. Arthropods were collected from grassland sites in Montana, USA, in the summer of 2011. The following three standardized evaluation criteria (consistency, reliability, and precision) were developed to assess the efficacy of sweep netting and pan trapping, based on analyses of variations in arthropod abundances, species richness, evenness, capture frequency, and community composition. Neither sampling method was sufficient in any criteria to be used alone for community‐level arthropod surveys. On a taxa‐specific basis, however, sweep netting was consistent, reliable, and precise for Thysanoptera, infrequently collected (i.e., rare) insects, and Arachnida, whereas pan trapping was consistent, reliable, and precise for Collembola and bees, which is especially significant given current threats to the latter's populations worldwide. Species‐level identifications increase the detected dissimilarity between sweep netting and pan trapping. We recommend that community‐level arthropod surveys use both sampling methods concurrently, at least in grasslands, but likely in most nonagricultural systems. Target surveys, such as monitoring bee communities in fragmented grassland habitat or where detailed information on behavior of the target arthropod groups is available can in some instances employ singular methods. As a general ecological principle, consistency, reliability, and precision are appropriate criteria to evaluate the applicability of a given sampling method for both community‐level and taxa‐specific arthropod surveys in any ecosystem.
From 2,6‐Dichloronicotinic Acid to Thiopeptide Cores
Authors: Just‐Baringo Xavier , Albericio Fernando , Álvarez Mercedes
Published: August 2013

The scope of 2,6‐dichloronicotinic acid as a precursor of thiopeptide polyheterocylic cores has been extensively studied in a cross‐coupling‐based approach. Differentiation of the two chlorinated positions under SNAr conditions and versatility of the carboxylic acid are key for the preparation of 2,3,6‐trisubstituted pyridines with complete regiocontrol. With the present strategy, nine different azole‐substituted pyridines were synthesized. Studies towards the selective deprotection of their functionalities resulted in a set of fully orthogonal protecting groups that permits the elongation of all three pyridine substituents.
Diastereoselective Addition of Organomagnesium and Organolithium Reagents to Chiral Trifluoromethyl N‐tert‐Butanesulfinyl Hemiaminals
Authors: Grellepois Fabienne , Ben Jamaa Abdelkhalek , Gassama Abdoulaye
Published: August 2013

The asymmetric synthesis of trifluoromethylated tertiary and secondary carbinamines (α,α‐dibranched and α‐branched amines) was achieved by reaction of alkyl, aryl and allyl organomagnesium or organolithium reagents to trifluoromethyl N‐tert‐butanesulfinyl hemiaminals, bench‐stable analogs of the corresponding ketoimines.
Integrative analysis revealed the molecular mechanism underlying RBM10‐mediated splicing regulation
Authors: Wang Yongbo , Gogol‐Döring Andreas , Hu Hao , Fröhler Sebastian , Ma Yunxia , Jens Marvin , Maaskola Jonas , Murakawa Yasuhiro , Quedenau Claudia , Landthaler Markus , Kalscheuer Vera , Wieczorek Dagmar , Wang Yang , Hu Yuhui , Chen Wei
Published: August 2013

RBM10 encodes an RNA binding protein. Mutations in RBM10 are known to cause multiple congenital anomaly syndrome in male humans, the TARP syndrome. However, the molecular function of RBM10 is unknown. Here we used PAR‐CLIP to identify thousands of binding sites of RBM10 and observed significant RBM10–RNA interactions in the vicinity of splice sites. Computational analyses of binding sites as well as loss‐of‐function and gain‐of‐function experiments provided evidence for the function of RBM10 in regulating exon skipping and suggested an underlying mechanistic model, which could be subsequently validated by minigene experiments. Furthermore, we demonstrated the splicing defects in a patient carrying an RBM10 mutation, which could be explained by disrupted function of RBM10 in splicing regulation. Overall, our study established RBM10 as an important regulator of alternative splicing, presented a mechanistic model for RBM10‐mediated splicing regulation and provided a molecular link to understanding a human congenital disorder.
Experimental implementation and verification of multi‐degrees‐of‐freedom effective force testing
Authors: Nakata Narutoshi , Krug Erin , King Aaron
Published: August 2013

This paper presents an experimental implementation and verification of multi‐degrees‐of‐freedom effective force testing (MDOF‐EFT). An experimental setup that consists of a two‐degrees‐of‐freedom structural system and two hydraulic actuators at the Johns Hopkins University was utilized in this study. First, experimental system identification was performed to develop compatible analytical models for the multi‐input and multi‐output systems. Dynamics of the control plant, that is, the valve‐to‐force relations, were modeled with a rational polynomial transfer function matrix and delay components. By using the analytical model, a centralized decoupling loop‐shaping force feedback controller was designed such that the forces are uncoupled and the loop transfer functions have desirable dynamic characteristics in the frequency domain. Then, a series of harmonic force and earthquake simulation tests were performed to assess capabilities and limitations of MDOF‐EFT. Experimental results showed that the dynamic forces in the two actuators were accurately controlled to provide tracking while the system was stable and robust for the entire period of the experiment. Furthermore, earthquake simulation tests with increased levels of the reference forces demonstrated the feasibility of MDOF‐EFT with highly nonlinear test structures. Copyright © 2013 John Wiley & Sons, Ltd.
Sulfur degassing at Erta Ale (Ethiopia) and Masaya (Nicaragua) volcanoes: Implications for degassing processes and oxygen fugacities of basaltic systems
Authors: de Moor J. M. , Fischer T. P. , Sharp Z. D. , King P. L. , Wilke M. , Botcharnikov R. E. , Cottrell E. , Zelenski M. , Marty B. , Klimm K. , Rivard C. , Ayalew D. , Ramirez C. , Kelley K. A.
Published: August 2013

We investigate the relationship between sulfur and oxygen fugacity at Erta Ale and Masaya volcanoes. Oxygen fugacity was assessed utilizing Fe3+/∑Fe and major element compositions measured in olivine‐hosted melt inclusions and matrix glasses. Erta Ale melts have Fe3+/∑Fe of 0.15–0.16, reflecting fO2 of ΔQFM 0.0 ± 0.3, which is indistinguishable from fO2 calculated from CO2/CO ratios in high‐temperature gases. Masaya is more oxidized at ΔQFM +1.7 ± 0.4, typical of arc settings. Sulfur isotope compositions of gases and scoria at Erta Ale (δ34Sgas − 0.5‰; δ34Sscoria + 0.9‰) and Masaya (δ34Sgas + 4.8‰; δ34Sscoria + 7.4‰) reflect distinct sulfur sources, as well as isotopic fractionation during degassing (equilibrium and kinetic fractionation effects). Sulfur speciation in melts plays an important role in isotope fractionation during degassing and S6+/∑S is <0.07 in Erta Ale melt inclusions compared to >0.67 in Masaya melt inclusions. No change is observed in Fe3+/∑Fe or S6+/∑S with extent of S degassing at Erta Ale, indicating negligible effect on fO2, and further suggesting that H2S is the dominant gas species exsolved from the S2−‐rich melt (i.e., no redistribution of electrons). High SO2/H2S observed in Erta Ale gas emissions is due to gas re‐equilibration at low pressure and fixed fO2. Sulfur budget considerations indicate that the majority of S injected into the systems is emitted as gas, which is therefore representative of the magmatic S isotope composition. The composition of the Masaya gas plume (+4.8‰) cannot be explained by fractionation effects but rather reflects recycling of high δ34S oxidized sulfur through the subduction zone.
Characterizing and estimating noise in InSAR and InSAR time series with MODIS
Authors: Barnhart William D. , Lohman Rowena B.
Published: August 2013

InSAR time series analysis is increasingly used to image subcentimeter displacement rates of the ground surface. The precision of InSAR observations is often affected by several noise sources, including spatially correlated noise from the turbulent atmosphere. Under ideal scenarios, InSAR time series techniques can substantially mitigate these effects; however, in practice the temporal distribution of InSAR acquisitions over much of the world exhibit seasonal biases, long temporal gaps, and insufficient acquisitions to confidently obtain the precisions desired for tectonic research. Here, we introduce a technique for constraining the magnitude of errors expected from atmospheric phase delays on the ground displacement rates inferred from an InSAR time series using independent observations of precipitable water vapor from MODIS. We implement a Monte Carlo error estimation technique based on multiple (100+) MODIS‐based time series that sample date ranges close to the acquisitions times of the available SAR imagery. This stochastic approach allows evaluation of the significance of signals present in the final time series product, in particular their correlation with topography and seasonality. We find that topographically correlated noise in individual interferograms is not spatially stationary, even over short‐spatial scales (<10 km). Overall, MODIS‐inferred displacements and velocities exhibit errors of similar magnitude to the variability within an InSAR time series. We examine the MODIS‐based confidence bounds in regions with a range of inferred displacement rates, and find we are capable of resolving velocities as low as 1.5 mm/yr with uncertainties increasing to ∼6 mm/yr in regions with higher topographic relief.
Evolution of geochemical variations along the Central American volcanic front
Authors: Saginor Ian , Gazel Esteban , Condie Claire , Carr Michael J.
Published: August 2013

New geochemical analyses of volcanic rocks in El Salvador add to existing data from Nicaragua and Costa Rica to create a comprehensive set of geochemical data for Central American volcanics. These data coupled with previously published 40Ar/39Ar ages covering the past 30 Ma show that Costa Rica and Nicaragua had similar U/Th and Ba/La values until 10 Ma when the region developed the distinctive along arc variations that made this margin famous. U/Th values increased in Nicaragua since the Miocene, while remaining unchanged along the rest of the volcanic front. This coincides temporally with the Carbonate Crash, which caused a transition in Cocos plate sediments from low‐U carbonates to high‐U, organic rich hemipelagic muds. Increases in uranium are not observed in Costa Rica because its lower slab dip produces a more diffuse zone of partial melting and because of the contribution from Galapagos‐derived tracks dilutes this signal. Ba/La has been used as a geochemical proxy for contributions from the subducting slab; however, our analyses indicate that the Ba concentrations do not vary significantly along strike either in the subducting sediment or the volcanic front. Along‐arc variation is controlled by changes in La, an indicator of the degree of partial melting or source enrichment. Trace element models of five segments of the volcanic front suggest that a subducting sediment component is more important to magmas produced in El Salvador and Nicaragua than in Costa Rica, where the geochemistry is controlled by recent (<10 Ma) recycling of Galapagos tracks.
An adoption scenario for carbon capture in pulverized coal power plants in the USA
Authors: Hanson Donald , Schmalzer David
Published: August 2013

In this paper we use the Electricity Supply and Investment Model (ESIM) power system model to examine the energy market effects of incentivized adoption of carbon capture and storage (CCS), with a primary focus on retrofitting existing pulverized coal plants. In the presence of a ‘medium’ carbon charge and least‐cost dispatch, units with CCS are operated with higher utilization rates than fossil energy plants without carbon capture, hence lowering CO2 emissions. This path helps to lower the capital outlays that will be necessary to make a transition to a full portfolio of advanced low‐carbon technologies. Required research, development and demonstration can be financed by a portion of the carbon charge revenue.
Auroral signatures of multiple magnetopause reconnection at Saturn
Authors: Radioti A. , Grodent D. , Gérard J.‐C. , Bonfond B. , Gustin J. , Pryor W. , Jasinski J. M. , Arridge C. S.
Published: August 2013

Auroral observations capture the ionospheric response to dynamics of the whole magnetosphere and may provide evidence of the significance of reconnection at Saturn. Bifurcations of the main dayside auroral emission have been related to reconnection at the magnetopause and their surface is suggested to represent the amount of newly opened flux. This work is the first presentation of multiple brightenings of these auroral features based on Cassini ultraviolet auroral observations. In analogy to the terrestrial case, we propose a process, in which a magnetic flux tube reconnects with other flux tubes at multiple sites. This scenario predicts the observed multiple brightenings, it is consistent with subcorotating auroral features which separate from the main emission, and it suggests north‐south auroral asymmetries. We demonstrate that the conditions for multiple magnetopause reconnection can be satisfied at Saturn, like at Earth.
Swallowing outcomes in patients with oropharyngeal cancer undergoing organ‐ preservation treatment
Authors: Starmer Heather M. , Tippett Donna , Webster Kimberly , Quon Harry , Jones Bronwyn , Hardy Sarah , Gourin Christine G.
Published: August 2013

Background

The purpose of this study was to assess swallowing outcomes in a cohort of patients with oropharyngeal squamous cell carcinoma (SCC) undergoing nonoperative treatment.

Methods

We conducted a retrospective study of patients who completed videofluoroscopic swallowing studies (VFSS) after nonoperative treatment of oropharyngeal SCC. All patients received intensity‐modulated radiation therapy (IMRT) ± chemotherapy. Swallowing abnormalities were recorded and the Penetration Aspiration Scale (PAS) quantified airway infiltration.

Results

Posttreatment VFSS (n = 71) occurred at an average of 4.69 months posttreatment. Abnormal PAS was noted in 45% of swallow studies. Swallowing decompensations included reduced pharyngeal constriction (75%), epiglottic tilt (70%), cricopharyngeal opening (42%), and hyoid excursion (42%). The only variable independently associated with abnormal PAS was pretreatment swallowing difficulty (odds ratio [OR] = 4.02; p = .009).

Conclusion

This study demonstrates that patients undergoing nonsurgical treatment for oropharyngeal SCC are at risk for posttreatment dysphagia. This suggests a need for dysphagia evaluation/management and refinement of interventions to minimize dysphagia. © 2014 Wiley Periodicals, Inc. Head Neck, 36: 1392–1397, 2014