bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrosynthesis of NiFe Layered Double Hydroxides with Gradient Structure for Oxygen Evolution Reaction
Authors: Zhong Qing , Song Xiaozhan , Wang Jingyi , Yu Wenhui , Tian Ruifen , Wang Yinling
Published: February 2025

Well-designed gradient electrodes often possess both good structural stability and high electrochemical activity. Herein, NiFe layered double hydroxide (NiFe LDH)-based gradient electrode was fabricated by two-step electrodeposition on nickel foam (NF) at different potentials (gradient potential method) with the assistance of O2. The NiFe LDH with gradient structure and composition displayed higher catalytic activity for oxygen evolution reduction (OER) and better long-term stability than the uniform NiFe LDH. At a current density of 50 mA cm−2, the overpotential of the optimum NiFe LDH based gradient electrode (G(1/4)-NiFe LDH) is only 295 mV. To achieve 10 mA cm−2, the voltage required by G(1/4)-NiFe LDH based electrolytic cell for overall water splitting is 1.52 V. In addition, the important role of O2 in the electrodeposition process was studied in detail. The O2-assisted gradient potential method is also applicable for the synthesis of other LDHs such as NiCo LDH and NiAl LDH. This study provides a facile and effective method to prepare LDHs with gradient structure and excellent OER performance.
Utilizing 13C-Labeled Internal Standards to Advance the Analysis of Heparan Sulfate
Authors: wang zhangjie , Liu Jian
Published: February 2025

Heparan sulfate is a highly sulfated and structurally heterogeneous polysaccharide that plays key roles in numerous biological processes. Due to its complex structure and variable sulfation patterns, accurately characterizing and quantifying HS in biological samples poses significant analytical challenges. This review presents an advanced LC-MS/MS methodology that utilizes isotope-labeled internal standards for the precise quantification of HS disaccharides and rare 3- O-sulfated tetrasaccharides, alongside monitoring 6- O-endosulfatase enzyme activity and the metabolism of synthetic HS oligosaccharides in biological systems. The combination of isotope-labeled standards with LC-MS/MS technology provides a powerful and sensitive approach for comprehensive analysis of HS modifications, offering valuable insights into HS metabolism and its alterations across various biological contexts.
The Association of VDR/FokI Gene Polymorphism and Protein Expression With Histopathological Alterations in Patients With Thyroid Colloid Nodule
Authors: Abdalfatah Mariwan F. , Shareef Abdullah A. , Saleh Lana S. , Rajab Mustafa F. , Smail Shukur W. , Abdulla Saman S. , Awla Harem Khdir , Ishaac Rivan H. , Ibrahim Kazhal S. , Ahmed Mazyar J. , Kakasur Fairuz A. , Rasul Khder Hussein
Published: February 2025

Objective: Colloid nodules are common and benign thyroid lesions that usually progress slowly and are asymptomatic. It requires follow‐up because untreated colloid nodules may develop into malignant tumor. The study aimed to examine the contributions of vitamin D receptor (VDR) expression, VDR/FokI (rs2228570) genotypes, and serum vitamin D level to the susceptibility to colloid nodules.

Methods: One hundred forty subjects (80 patients and 60 controls) were enrolled and VDR FokI was determined by PCR in formalin fixed paraffin embedded (FFPE) blocks of the patients and blood of controls. Moreover, VDR protein expression was evaluated by immunohistochemistry using specific VDR monoclonal antibody in the tissue sections of patients and serum vitamin D were measured simultaneously using enzyme‐linked immunosorbent assay (ELISA).

Results: Sixty‐two (77.5%) cases showed strong immunoreactivity score (IRS) of cytoplasmic staining. Strong IRS were significantly observed in samples with larger nodule size (p value: 0.0094), multinodules (p value: 0.0054), and carriers of CC genotypes (p value: 0.0034). TT homozygous genotype revealed significantly (p value: 0.029 and odds ratio (OR): 0.11) protective factor for colloid nodules. In addition, nodule size was significantly (p value: 0.016) larger among CC carriers. Moreover, vitamin D level and category were nonsignificantly difference between patients and controls.

Conclusion: Our results reveal prominent cytoplasmic VDR expression, suggesting a distinct distribution pattern and offering valuable insights into its potential role in colloid nodules. VDR expression increases with increasing size and number of nodules. Regarding FokI genotypes, TT genotype was less likely to develop colloid nodule. These findings contribute to our understanding of cellular characteristics of this condition and may have implications for future research and clinical management.
Esophageal Achalasia: An Unusual Cause of Respiratory Distress
Authors: Thiry Océane , Schaefer Marion , Cravoisy Aurélie , Nace Lionel , François Thibault , Allard Jacques , Gibot Sébastien
Published: February 2025

Esophageal achalasia is a rare condition affecting both men and women. It is a motility disorder of the esophagus resulting in the lack of relaxation of the lower sphincter, yielding to food stasis. While the condition typically presents with dysphagia and regurgitation, advanced stages may lead to severe complications including dyspnea and even acute respiratory distress. We herein report the case of a patient admitted to an intensive care unit following emergency prehospital management for acute respiratory failure and hemodynamic instability. The patient required invasive mechanical ventilation and vasopressor support due to tracheal compression and involvement of the cardiac, arterial, and venous structures. The diagnosis of esophageal achalasia was initially suspected. Based on CT, endoscopic esophageal decompression was performed, the situation dramatically improved, and diagnosis was subsequently confirmed by esophageal manometry.
Chronic Kidney Disease With Related Oral Health Problems and Alterations in the Tongue Microbiome Illustrated by a 15‐Year‐Old Girl: A Case Report
Authors: Hoefer Karolin C. , Weber Lutz T. , Jazmati Nathalie , Noack Michael J. , Barbe Anna Greta , Graf Isabelle
Published: February 2025

Chronic kidney disease (CKD) is characterised by a gradual loss of kidney function over time and is often linked to oral health issues. This case illustrates typical conditions in young CKD patients based on a 15‐year‐old girl with CKD stage 4 and methylmalonic aciduria, severe gingivitis and hyperplasia of the gingiva, and a need for orthodontic treatment. Oral hygiene interventions, homecare instructions and deep cleaning under antibiotic shielding were necessary to improve the patient’s oral health. The immediate worsening of oral health status after extending the interval between regular prophylaxis appointments highlights the need for intensive prevention in young CKD patients to control oral health disorders. This report aims to demonstrate burden‐of‐care‐reducing oral prophylaxis options for patients suffering from severe CKD with oral manifestations.

Trial Registration: German Registry of Clinical Trials: DRKS00010580
Neurophysiological Signatures of Major Depressive Disorder and Frontocentral Gamma Auditory Response Deficits
Authors: Liu Xiaoya , Liu Shuang , Su Fangyue , Zhang Wenquan , Ke Yufeng , Ming Dong
Published: February 2025

Background: Aberrant gamma oscillations in major depressive disorder (MDD) have attracted extensive attention, but evidence delineating such neural signatures is lacking. The auditory steady‐state response (ASSR) elicited by periodic auditory stimuli is a robust probe of gamma oscillations. Here, we sought to characterize early transient auditory evoked responses (AEPs) and sustained gamma ASSRs in MDD, thereby identifying reliable neurophysiological signatures and providing preliminary interpretations of gamma auditory response deficits in MDD.

Methods: Electroencephalographic data were obtained from 40 first‐episode drug‐naïve patients with MDD and 41 demographically matched healthy controls (HCs) during a 40‐Hz ASSR paradigm, encompassing two periodic stimuli—chirp and click stimuli. Source analysis of transient AEPs was performed to identify generators involved in early information processing dysfunction. In addition, spectrotemporal and spatial characteristics of 40‐Hz ASSRs were analyzed using event‐related spectral perturbation, inter‐trial phase coherence, and functional connectivity index.

Results: Compared to HCs, patients showed a reduced P200 amplitude that was source‐localized to the middle temporal gyrus, possibly reflecting an underlying impairment in the processes of early allocation or auditory information perception within the auditory pathways. Meanwhile, attenuated 40‐Hz power and phase coherence, in conjunction with suppressed right frontotemporal and frontocentral connectivity, were observed in MDD, highlighting the multidimensional entrained gamma inhibition. Correlation analyses revealed that the decreased right frontocentral connectivity was strongly related to increased anxiety severity. Importantly, these abnormalities correlated with the patient’s symptoms were only found with the chirp stimulus, suggesting that the chirp stimulus has tremendous potential to reveal specific neurophysiological signatures of MDD.

Conclusions: Our data reveal impaired gamma auditory responses in first‐episode drug‐naïve patients with MDD and suggest that right frontocentral connectivity elicited by the chirp stimulus may represent a promising signature for predicting clinical symptoms.
Open‐Circuit Fault Detection Strategy in Grid‐Tied NPC Inverters Using Distorted Current and Model Predictive Control
Authors: Mechri Hadjira , Kheldoun Aissa , Touati Mohamed Tamim , Khettab Soufiane , Ammar Abdelkarim , Belkhier Youcef , Khosravi Nima , Oubelaid Adel
Published: February 2025

Investigating and addressing fault detection is crucial for advancing the reliability, performance, and cost‐effectiveness of grid‐connected inverter systems, thereby contributing to the stability and efficiency of modern power grids. This study introduces a novel approach for detecting and classifying open‐circuit faults (OCFs) in three‐level neutral point clamped (3‐L‐NPC) inverters connected to the grid. The proposed algorithm swiftly identifies faulty switches and clamping diodes using distorted current signals and model predictive control (MPC), eliminating the need for additional hardware or complex computations. By addressing the challenge of identifying the specific switch under grid‐connected conditions, the proposed method achieves faster detection and identification of all switches and clamping diodes in less than one fundamental period which is very good compared with recent studies and considering that no extra sensors are used. Furthermore, this work demonstrates the efficacy of MPC in tolerating OCFs in clamping diodes, showcasing its potential to enhance system resilience and performance. The proposed strategy significantly improves the reliability of 3‐L‐NPC inverters by ensuring prompt and accurate fault detection and classification. Both experimental and simulation results confirm the efficacy of the suggested fault detection and identification approach, emphasizing its practical applicability in real‐world grid‐tied inverter systems.
Optimized Selection of Renewable Energy Sources Based on Regional Potentials in Colombia: A Comparative Analysis of AHP and FAHP for Sustainable Development
Authors: Rocha Christian Manuel Moreno , Buelvas Daina Arenas , Machado Itzjak Vega , Peña Juan Pacheco
Published: February 2025

This study evaluates alternatives using the analytic hierarchy process (AHP) and Fuzzy AHP (FAHP) methodologies across five scenarios (SC1 to SC5), aiming to compare the effectiveness of both approaches in integrating environmental and technical criteria. The results indicate that, in SC1, AHP assigns weights of 14.35% to A1 and 16.22% to A2, while FAHP demonstrates greater dispersion, highlighting A6 with 35.22%. In SC2, AHP prioritizes A1 with 14.16%, whereas FAHP increases the weight of the environmental criterion to 21.18%. In SC3, A1 remains the preferred option in both methodologies, with close weights of 34.00% for AHP and 32.98% for FAHP. In SC4, both methods show similar trends, with A1 standing out at 11.12% and A4 at 34.87%. Finally, in SC5, AHP allocates 8.52% to A1, while FAHP evaluates it at 10.73%. The findings suggest that FAHP allows greater sensitivity to variations in sub‐criteria, enabling a more precise evaluation aligned with sustainability objectives. The significance of environmental and social criteria across the scenarios underscores the necessity of incorporating more sustainable approaches into decision‐making processes. It is concluded that, while AHP delivers consistent results, FAHP may be better suited for contexts characterized by complexity and uncertainty. Furthermore, sensitivity analysis is recommended to examine how variations in criterion weights impact final decisions.
Clinical Association of Negative Lymph Nodes With Adjuvant Chemotherapy in Patients With T3N0 Rectal Cancer
Authors: Lei Dongxu , Liu Zhanzhen , Kang Xinyi , Zeng Ziwei , Xie Hao , Cai Tanxing , Ye Fujin , Xiong Li , Li Wenxin , Liang Zhenxing , Zheng Xiaobin , Luo Shuangling , Liu Huashan
Published: February 2025

Background: The use of adjuvant chemotherapy in patients with stage T3N0 rectal cancer following total mesorectal excision (TME) is debated. This study is aimed at investigating the clinical significance of negative lymph node (NLN) counts in patients with T3N0 rectal cancer, particularly in relation to adjuvant chemotherapy.

Methods: This retrospective analysis examined 311 patients with T3N0 rectal cancer who underwent radical resection at the Sixth Affiliated Hospital of Sun Yat‐sen University between August 2014 and December 2021. The optimal cutoff for NLN counts was determined using receiver operating characteristic (ROC) curves. Clinicopathological characteristics and clinical outcomes were compared between the high and low NLN groups. Overall survival (OS) and disease‐free survival (DFS) were used to evaluate the efficacy of adjuvant chemotherapy.

Results: The optimal cutoff for NLNs was 21. Of the 311 patients, 141 were categorized into the high NLN group and 170 into the low NLN group. Patients with NLNs ≥ 21 had significantly better 5‐year OS (99.3% vs. 88.2%, p < 0.05) and 5‐year DFS (92.2% vs. 79.4%, p < 0.05) compared to those with low NLNs. Multivariate Cox analysis revealed that NLN count was an independent prognostic factor for OS (hazard ratio (HR) = 0.078, 95% confidence interval (CI): 0.011–0.582, p = 0.013) and DFS (HR = 0.417, 95% CI: 0.213–0.815, p = 0.011). Subgroup analysis indicated that adjuvant chemotherapy significantly improved OS (p < 0.05) and DFS (p < 0.05) in the low NLN group.

Conclusion: NLN count is an independent prognostic factor in patients with T3N0 rectal cancer. Patients with low NLN counts (NLN < 21) may benefit from adjuvant chemotherapy.
In Vitro, In Vivo, and In Silico Investigation of Synbiotic‐Mediated Activation of PPAR‐α Curtails Nonalcoholic Steatohepatitis (NASH) in Wistar Rats by Inhibiting PNPLA3/SREBP1‐c Lead Inflammatory Injury of Hepatic Cells
Authors: Sharma Dixa , Patel Dhara , Mandal Palash
Published: February 2025

Nonalcoholic steatohepatitis (NASH) is an inflammation of the liver and a menace to human health. To treat NASH various pharmaceutical products have been used, but their prohibitive side effects limit their effectiveness. NASH, a multihit hypothesis involves high‐fat diet and signals from the gut to the liver. Lactobacillus plantarum (probiotic) and aged garlic extract (AGE, a prebiotic) are antioxidative and anti‐inflammatory and may be a latent combination therapy for NASH. The NASH model was developed using Wistar rats and treatments were administered to understand the mechanism. Initially, in the in vitro models, transepithelial electrical resistance (TEER) 2′‐7′‐dichlorodihydrofluorescein diacetate (DCFDA), 4‐6‐diamidino‐2‐phenylindole (DAPI) labeling and Oil Red O (ORO) conducted on HepG2 and Caco2 cells. Afterwards, in in vivo studies rat liver tissues were examined through confocal microscopy using the ORO staining and hematoxylin and eosin (H/E) stain, malondialdehyde (MDA), and biochemical indices were recorded. The levels of patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) and sterol regulatory element binding protein‐1c (SREBP‐1c), peroxisome proliferators activated receptors (PPARs)‐α, inflammatory, and apoptotic biomarkers were quantified by qRT‐PCR. Synbiotic reduced the hepatic inflammation and apoptosis examined through the levels of PNPLA3, SREBP‐1c, IL‐6, TGF‐β, Bcl‐2, and caspase‐3 in NASH models. In turn, the gram‐negative species and bacterial translocation associated were reduced. Consequently, the Insilco analysis supports the theory that each (eight) bioactive compound of AGE targets PNPLA3 and enhances the PPAR‐α activity. Additionally, PPAR‐α inhibitors upregulated the PNPLA3 and SREBP‐1C expression. As a result, the synbiotic may inhibit NASH progression by affecting PNPLA3/SREBP1‐c through PPAR‐α.
Effects of Client‐Centered Occupational Therapy Intervention in Older Adults With Depression: A Randomized Controlled Trial
Authors: Jeong HyeongGi , Kim DeokJu
Published: February 2025

Objective: The purpose of this study was to determine the impact of client‐centered occupational therapy intervention on the mental health, activities of daily living (ADL), and community participation of older adults with depression.

Methods: This study was a single‐blind, randomized controlled study conducted on older adults with depression, and those who met the selection and exclusion criteria were randomly divided into an experimental group of 15 people and a control group of 15 people. The experimental group performed client‐centered occupational therapy intervention using the Canadian Occupational Performance Measure (COPM) and Barth Time Construction (BTC), and the control group performed case management and a strength‐brain exercise program. Both groups underwent intervention twice a week for 60 min, for a total of 16 sessions. Before and after the intervention, depression, anxiety, stress, ADL, and community partitioning were measured using assessment tools with proven reliability and validity in both the experimental group and the control group.

Results: The experimental group exhibited significant changes after the intervention in depression, anxiety, stress, social integration, and community integration scores (p < 0.05 and p < 0.01), while the control group showed significant changes only in depression scores (p < 0.05). As a result of comparing the amount of change between the experimental and control groups, significant differences were found in social integration among the areas of depression, stress, and community integration (p < 0.05 and p < 0.01).

Conclusion: These results suggest that client‐centered occupational therapy intervention could serve as an effective intervention for improving mental health, ADL, and community participation in older adults with depression.

Trial Registration: Korea Clinical Research Information Service (CRIS): KCT0009358
Validation by Expert Groups of the Conceptual and Structural Dimensions in the AcompdogSMP+ Nursing Program: A Dog‐Assisted Therapy to Promote Positive Mental Health
Authors: Balaguer-Sancho Judith , Puig-Llobet Montserrat , Lluch-Canut Maria Teresa , Tinoco-Camarena Jose , Agüera Zaida , Moreno-Arroyo Carmen
Published: February 2025

Introduction: AcompdogSMP+ is a nursing program for the promotion of positive mental health using a dog‐assisted therapy for individuals with severe mental disorders.

Objective: To validate the content validity of the four conceptual and the three structural dimensions that shape AcompdogSMP+.

Design and Methods: Three expert groups with a total of 28 participants were convened, associated with the three core areas of the program (i.e., the multifactorial model of positive mental health, the “animal‐assisted therapy” nursing interventions taxonomy, and the animal‐assisted therapy as a complementary intervention model). The qualitative data were analyzed using an existing text analysis method, and the notes taken by the moderator and an assistant. The quantitative data were analyzed through the content validity index (CVI) for 68 different items that made up the seven dimensions of the AcompdogSMP+ program, through the data obtained from an ad hoc Likert‐type scale.

Results: The degree of agreement of the experts was complemented with the values obtained in the results of the quantitative data. CVI values of virtually all items were excellent (greater than 0.78). Only one item had a CVI considered good (I‐CVI = 0.68). The values of the Scale Content Validity Index (S‐CVI/Ave) ranged from 0.88 to 1.00, with most of the indices being excellent (above 0.90).

Conclusion: The results supported the content validity of the seven dimensions, of the AcompdogSMP+ program. The validation might allow its clinical validation, through its implementation in healthcare practice, as well as the evaluation of its effectiveness.

Implication for Practice: To our knowledge, this is the first animal‐assisted therapy nursing program to promote positive mental health validated by expert judgment. By confirming the content validity of each dimension, robustness and empirical evidence is given to integrate the program into clinical practice with confidence, offering a structured and complementary intervention aimed at improving mental health outcomes and overall well‐being of patients with severe mental disorders. This could lead to greater patient engagement, improved therapeutic outcomes, and a more holistic approach to mental health.
Table S1 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Supplementary Table 1 shows enriched gene sets upregulated in CAOV3 cells treated with talazoparib.
Six Cases of Polypoidal Choroidal Vasculopathy in eyes with Choroidal Nevi
Authors: Gaggino Andrea , Inferrera Leandro , Milan Serena , Presotto Marianna , Tognetto Daniele
Published: February 2025

Introduction: To report the cases of six patients with the coexistence of Polypoidal Choroidal Vasculopathy (PCV) and choroidal nevi.
Cases presentation: Six patients with the coexistence of PCV and choroidal nevi were thoroughly evaluated by slit-lamp biomicroscopy examination, color fundus photography, optical coherence tomography (OCT), OCT angiography (OCT-A) fluorescein angiography (FA), indocyanine green angiography (ICG-A), fundus blue autofluorescence (BAF), and ocular ultrasound (OU). The typical features of PCV and nevi were present in all patients, three of whom were treated with intravitreal anti-angiogenic agents. In each clinical case, the choroidal Haller's vessels adjacent to the nevus were visibly more dilated compared to normal. Color fundus photography, OCT, OCT-A, FA, ICG-A, BAF, and OU revealed similar findings across all cases. Observations revealed that choroidal nevi could instigate modifications in the outer retina, resulting in persistent alterations capable of triggering the formation of neovascularization.
Conclusion: The occurrence of a PCV alongside nevus is an uncommon complication. We present the largest monocentric cohort of eyes with PCV associated with choroidal nevi. Findings from all exams performed were consistent across all cases, highlighting the potential link between PCV and nevi.
Comorbidity Patterns in Patients with First-ever Acute Ischemic Stroke and Their Associations with Functional Outcomes
Authors: Huang Xinying , Lu Zuolin , Li Tianqi , Zhang Juan , Meng Xia , Wang Yachen , Shao Weihao , Wei Xiaoxia , Jiang Yong , Shao Ruitai
Published: February 2025

Background and purpose: Acute ischemic stroke (AIS) is the most prevalent type of stroke, associated with a significant burden of functional impairments. About 94.2% of AIS patients present with multiple comorbidities, but how they affect AIS prognosis remains largely unknown. This study aims to comprehensively assess the associations of a wide range of AIS-related comorbidities, their patterns, with functional impairments in AIS patients.

Method: This study utilized data from the China National Stroke Registry 3 (CNSR3), a prospective registry encompassing 201 Chinese hospitals from August 2015 to March 2018. A total of 10,508 AIS patients were included, with a median age of 62.0 years (IQR: 54.0–70.0), and 65% were female. Eighteen AIS-related comorbidities were considered in the analysis and frequent pattern mining was employed to identify potential comorbidity patterns among AIS patients. Functional outcomes at one year after an AIS event were assessed using the Modified Rankin Scale (mRS). Logistic regression models were utilized to evaluate associations of comorbidities, their patterns with AIS prognosis. Furthermore, association rule mining was applied to explore the hidden comorbidity combinations, and their relationship with functional outcomes based on the identified patterns.

Results: Comorbidity was observed in 88.9% of AIS patients. The majority of AIS patients exhibited one to three comorbidities. Eight patterns of main comorbidities among AIS patients were identified. The pattern of common metabolic disorders, coronary heart disease, and atrial fibrillation demonstrated the strongest association (OR = 2.49, 1.59 to 3.89) with the development of poor functional outcomes. The further combination of heart failure, and arthritis significantly increases the probability of poor functional outcomes, with lifts of 3.11 and 5.52, respectively.

Conclusions: Our study revealed that comorbidity is highly prevalent among AIS patients in China, encompassing diverse patterns. Specific comorbidities and comorbidity patterns are closely associated with poor functional outcomes. Our findings emphasized the importance of prioritizing comprehensive management of AIS and AIS-related comorbidities to reduce the risk of disability among AIS patients.
Two new deep-water alpheid shrimps from the Indo-West Pacific (Malacostraca: Decapoda: Caridea)
Authors: Anker Arthur
Published: February 2025

In the present study, two deep-water species of the caridean shrimp family Alpheidae are described from two localities in the Indo-West Pacific, each based on a single specimen. Bannereus kebir sp. nov. is described based on a female holotype collected at a depth of 230‑243 m in the Kai Islands, Indonesia. The new species can be easily separated from the two congeners, B. anomalus Bruce, 1988 and B. chani Anker & Pachelle, 2020, by the presence of strap-like epipods on the first to third pereiopods. Salmoneus profundus sp. nov. is described based on an incomplete hermaphrodite holotype collected at a depth of 218‑225 m near Hanover Island, Papua New Guinea. This species differs from all other species of Salmoneus Holthuis, 1955 by the shape and armature of the enlarged minor cheliped, the elongate walking legs, and the absence of a strap-like epipod on the fourth pereiopod. It also represents by far the deepest-known member of Salmoneus, since all other known species in this genus occur at depths shallower than 90 m.
New species and records of Leucospis Fabricius, 1775 (Hymenoptera, Leucospidae) from Brazilian savannah in Central Brazil
Authors: Perioto Nelson Wanderley , Lara Rogéria Inês Rosa
Published: February 2025

This study documented the species of Leucospis Fabricius, 1775 (Hymenoptera, Leucospidae) found in Parque Nacional da Chapada dos Veadeiros, Alto Paraíso de Goiás, Goiás state, and Parque Nacional Grande Sertão Veredas, Chapada Gaúcha, Minas Gerais state, Brazil. Surveys were conducted using Malaise, Möricke and light traps, and sweep nets over a year, from February 2018 to May 2019. During these samplings four species of Leucospis were captured: L. claudomiroi sp. nov. Perioto and Lara (16 specimens), L. aliena Bouček, 1974 (26), L. enderleini Ashmead, 1904 (five), and L. cayennensis Westwood, 1839 (one). Leucospis aliena and L. enderleini are recorded for the first time in Goiás and Minas Gerais states, while L. cayennensis is newly recorded for Goiás.
Implementação do orçamento alinhada à inovação de produtos no setor de telecomunicações
Authors: Machado Fabíola Tibúrcio , Lavarda Carlos Eduardo Facin , Hillen Cristina
Published: February 2025

This study examines the implementation of budgeting aligned with product innovation in a telecommunications company. It is a qualitative and descriptive research conducted through a case study in a large Brazilian company in the telecommunications sector. Data were collected and analyzed through semi-structured interviews, documents, and observations, adopting the framework of Chenhall and Langfield-Smith (1999) and focusing on the budget as an instrument of administrative innovation. The results indicate that one of the main triggers for budget implementation is radical product innovation, due to its impact on revenue, investments, and enhanced control. The evidence highlights the budget implementation process as a managerial tool contributing to innovation. This research contributes to managerial literature by exploring the connections between formal controls and innovation, which present ambiguous results in the literature, while demonstrating that budgetary interactions can foster radical product innovations.
Uso de mídia social pelo CEO e a relevância da informação contábil
Authors: Klann Roberto Carlos , Giordani Mikaéli da Silva
Published: February 2025

Aborda-se o papel dos CEOs como o principal comunicador corporativo e símbolo da identidade da empresa, sendo que a divulgação de suas opiniões por meio de mídias sociais pode afetar a empresa. Esta pesquisa objetivou analisar o efeito das publicações dos CEOs na mídia social do LinkedIn, relacionadas às empresas nas quais atuam, na relevância da informação contábil. A população é formada por empresas que compõem o IBrX100. Foram analisados dados anuais e operacionalizadas regressões OLS com erros padrão robustos. O período de análise correspondeu ao tempo de atuação do último CEO de cada empresa. Os resultados demonstram que o uso da mídia social pelo CEO contribui para a relevância da informação contábil. Adicionalmente, o teste de sensibilidade demonstrou que quanto maior o número de publicações, curtidas e comentários, maior o efeito no market-to-book, o que sugere que a interação entre CEO e o mercado por meio do LinkedIn melhora a relevância da informação contábil. A contribuição deste estudo consiste nas evidências empíricas de que a comunicação do CEO no LinkedIn, verificada por meio das publicações relacionadas à empresa, favorece o engajamento com os seus stakeholders, observado por meio das curtidas e comentários, o que pode refletir na relevância da informação contábil da empresa perante o mercado e, consequentemente, influenciar positivamente a qualidade da informação contábil.
Acompanhamento assistencial das pessoas amputadas após alta de um programa de reabilitação física
Authors: Silva Letícia Cunha da , Silva Elizabeth Vieira da , Matos Celso Vilella , Souza Camila Carneiro de , Silva Elaine Cristina da
Published: February 2025

Estima-se que mais de um bilhão de pessoas convivam com alguma forma de deficiência, dentre as quais aproximadamente 200 milhões experimentam dificuldades funcionais consideráveis. E de acordo com o relatório da Organização Mundial de Saúde (2012),1 as pessoas com deficiência apresentam níveis de escolaridade mais baixos, piores perspectivas de saúde e taxas de pobrezas mais elevadas em comparação às pessoas sem deficiência. No Brasil, o acesso integral à saúde da pessoa com deficiência em todos os níveis de complexidade é um direito assegurado pelo artigo 18 do Estatuto da Pessoa com Deficiência (Lei 13.146/2015), assim como sua reabilitação.
Avaliação da mobilidade funcional e reabilitação em pacientes idosos submetidos à artroplastia
Authors: Rezende Leonardo Pinheiro , Trindade Andrei Machado Viegas da , Cordeiro Lorraine Barbosa , Oliveira Claudia Santos
Published: February 2025

A osteoartrose caracterizada pela degeneração da cartilagem compromete a funcionalidade de pacientes. A abordagem cirúrgica com prótese de joelho é considerada quando a deterioração impacta significativamente a qualidade de vida dos pacientes.
Cannabis medicinal na lesão medular: aplicabilidade e considerações práticas
Authors: Helfenstein Thomas , Costa Thadeu Rocha da , Souza Daniel Rubio de
Published: February 2025

Lesões da medula espinhal (LME) são uma prioridade de saúde global. Na população com LME, estima-se que 65-78% dos indivíduos relatam sintomas de espasticidade, no primeiro ano após a lesão. Até 80% das pessoas com LME sentirão dor neuropática. A ineficiência do modelo de tratamento atual levou as pessoas com LME a explorar métodos alternativos, como o uso da Cannabis medicinal (CM), para controlar as complicações.
Caracterização da função respiratória de indivíduos com lesão medular acima de T6
Authors: Rodrigues Ana Cláudia , Silva Mayna Ferreira da , Silva Larissa , Marques Daniel da Silva , Padula Natalia
Published: February 2025

A Lesão Medular (LM) é definida como qualquer lesão que afete os elementos neurais do canal medular com repercussões motoras, sensitivas e autonômicas. A classificação da lesão é dependente da combinação do nível neurológico e completude da lesão.
Composição corporal em pacientes com osteoartrite de joelho
Authors: Lopes Rosana Aparecida de Freitas , Salles Luciana Silva de , Carvalho Tainan Dias , Imamura Marta , Battistella Linamara Rizzo
Published: February 2025

A osteoartrite de joelho (OAJ) é a forma mais comum de artrite em adultos e uma das principais causas de anos vividos com incapacidade. A OA é caracterizada por dor crônica e perda de mobilidade. A OAJ é um grande fardo para os sistemas de saúde do mundo. O Ministério da Saúde do Brasil patrocinou uma pesquisa de políticas e sistemas de saúde para investigar novas intervenções para aperfeiçoar o cuidado de pessoas com dor crônica incapacitante por OA primária (OA PRONAS). A OAJ apresenta como fatores de risco idade, peso corporal, além de componentes genéticos.
Conhecimento de Medicina Física e Reabilitação por estudantes do sexto ano de medicina: estudo comparativo
Authors: Ticeu Paolo Kam , Rocha Eduardo de Melo Carvalho , Akamine Eduardo Hideyuki , Lazar Fernando , Saad Ana Paula Naomi , Shimada Mauricio Shigueru
Published: February 2025

A reabilitação, restaurando funcionalidade e autonomia diante de incapacidades causadas por doenças, remonta a tempos antigos. No entanto, foi nos séculos XIX e XX que a reabilitação propriamente dita surgiu, principalmente após as Guerras Mundiais. Nos Estados Unidos e na Europa, centros de reabilitação começaram a ser projetados com o objetivo de reabilitar soldados incapacitados almejando devolver seu potencial funcional máximo e permitir seu retorno à sociedade.
Correlação entre mobilidade funcional e nível de atividade física em indivíduos com hemiparesia espástica pós acidente vascular cerebral
Authors: Souza Rafaela Batista , Barros Kaylla Laurena , Oliveira Juliana Aquino Freitas de , Matos Celso Vilella , Silva Elaine Cristina da
Published: February 2025

O Acidente Vascular Cerebral (AVC) é uma síndrome de rápido desenvolvimento, sendo uma das principais causas de morte e incapacidade em adultos mundialmente. Apresenta como consequências, em diferentes níveis de gravidade, comprometimentos motores, cognitivos e sensoriais. Uma das sequelas motoras do AVC é a hemiparesia espástica, caracterizada por fraqueza no hemicorpo contralateral à lesão, associada ao aumento de tônus muscular em determinados grupos musculares, a depender da extensão da lesão.
Desafios do tratamento da Displasia de Desenvolvimento de Quadril (DDQ) com gesso pelvipodálico
Authors: Kunkel Maria Elizete , Santos Natália Aurora dos , Goiano Ellen de Oliveira , Souza Paula Ide Coelho de , Rorato Eduardo Keller
Published: February 2025

A displasia do desenvolvimento do quadril (DDQ) é uma condição da ortopedia pediátrica significativa, caracterizada por diversas alterações que podem afetar a região do quadril. Estas alterações vão desde instabilidade e alterações na formação do acetábulo até o desencaixe parcial ou total da cabeça femoral. O diagnóstico precoce e o tratamento da DDQ são cruciais para evitar complicações articulares no futuro. A ausência de tratamento está associada a morbidades a longo prazo, incluindo marcha anormal, dor crônica e artrite na fase adulta.
Eletrodiagnóstico de hérnia abdominal através de técnicas neurofisiológicas não convencionais: um relato de caso
Authors: Camargo Amaro José Silveira , Alexandre Andrea , Pellegrinelli Ada
Published: February 2025

Compressão de nervo cutâneo não é resultado incomum de cirurgias, até 30% dos pacientes, e pode levar à dor crônica significativa e difícil de tratar. Sem tratamento, tal aprisionamento pode causar neuropatia e danos às estruturas e musculatura inervadas, além de morbidade e perdas financeiras significativas. A compressão nervosa é definida como neuropatia de pressão por compressão crônica, causando alterações em todas as camadas do tecido nervoso. Está mais significativamente associada ao reparo de hérnia e outros procedimentos que utilizam uma incisão abdominal inferior, como a Pfannenstiel, e cirurgias toracoabdominais ou de cunho estético.
Melhora significativa da síndrome tremor-ataxia cerebelar sequelar após reabilitação física potencializada por estimulação cerebral profunda (DBS): acompanhamento de 5 anos
Authors: Padula Natalia , Rodrigues Ana Cláudia , Souza Daniel Rubio de , Ghilardi Maria Gabriela dos Santos , Fonoff Erich Talamoni
Published: February 2025

A síndrome de Tremor/Ataxia secundária à degeneração cerebelar paraneoplásica é uma condição grave e geralmente irreversível, caracterizada por tremor intenso e ataxia axial ou apendicular, resultando em prejuízos funcionais graves. O tremor é resistente ao tratamento clínico, exigindo DBS para controle, mas não há tratamentos eficazes para a ataxia. A reabilitação física intensiva é a única abordagem registrada para melhorar esses pacientes.
Osteopenia e osteoporose em crianças com paralisia cerebral: uma revisão integrativa
Authors: Oliveira Sofia Juelle de , Silva Filho Francivaldo Araújo , Sarmento Viviane Porangaba , Chiappetta Lorella Marianne , Pinto Junior Alexandre Otilio
Published: February 2025

A Paralisia Cerebral (PC) é um distúrbio neurológico decorrente da isquemia encefálica em recém-nascidos e crianças de baixa idade. Uma de suas possíveis complicações surge a partir da perda mineral óssea, que pode levar à osteopenia e à osteoporose.
Recuperação celular na qualidade do sono: revisão bibliográfica
Authors: Castro Victor Augusto de
Published: February 2025

Décadas de pesquisa experimental destacaram quais aspectos e mecanismos do sono são susceptíveis de estar subjacentes nas diversas formas de recuperação. Dentre elas, destaca-se a redução recorrente da atividade corporal, diminuição da atividade do metabolismo e sensibilidade, mas prontamente reversível a estímulos externos.
Resultados do bloqueio facetário e de sacroilíacas guiado por fluoroscopia como tratamento para dor lombossacra - um estudo piloto
Authors: Zanelatto Claudiane de Paiva Alves , Caron Michel , Ferreira Sergio Luiz  Gomes , Sousa Luciana Botega de
Published: February 2025

A articulação facetária é uma articulação sinovial, envolvida por uma cápsula ricamente vascularizada e inervada pelo ramo medial do ramo dorsal do nervo espinhal. Diversas condições podem levar à doença facetaria. Sendo a causa mais frequente de doença facetária a osteoartrite de caráter degenerativo, que leva à perda da cartilagem articular, erosões marginais, hipertrofia dos processos articulares, instabilidade e dor.
Síndrome camptodactilia-artropatia-coxa-vara-pericardite: revisão bibliográfica
Authors: Corrales Daniela Rendon , Silva Wagner Thales
Published: February 2025

A síndrome camptodactilia-artropatia-coxa-vara-pericardite (CACP) é uma doença ocasionada pelas mutações no gene proteoglicano 4 (PRG4), codificador da glicoproteína Lubricina. Esta substância tem função de lufricar as estruturas articulares e, assim, evitar a deterioração progressiva devido seu papel condoprotetor.
Síndrome de Stiff Person: relato de caso de paciente acompanhada no ambulatório de neurorreabilitação
Authors: Fonseca Marcos Matheus da Silva , Moares Lucas Levy Alves de , Chen Samuel Fen I , Tachibana Amanda Rie , Akamine Eduardo Hideyuki
Published: February 2025

A Síndrome da Pessoa Rígida (SPR) é um distúrbio neurológico autoimune raro caracterizado por rigidez muscular progressiva, espasmos musculares dolorosos, disautonomia, dificuldade de marcha, quedas frequentes e perda de funcionalidade. Outros sintomas podem incluir fadiga, dor, disartria, disfagia, ansiedade e depressão.
Tratamento por ondas de choque como estratégia complementar para manejo de espasticidade em pacientes com lesão encefálica: uma série de casos
Authors: Costa Thadeu Rocha da , Ferreira Valeska Beatrice , Helfenstein Thomas , Shinzato Gilson Tanaka , Battistella Linamara Rizzo
Published: February 2025

A espasticidade é uma das sequelas decorrentes de lesões encefálicas como acidente vascular cerebral e traumatismo cranioencefálico. Faz parte da síndrome do neurônio motor superior e se caracteriza como uma hipertonia elástica decorrente da hiperexcitabilidade dos fusos musculares. Pode ocasionar dor e repercussões funcionais negativas prejudicando a performance no treino de marcha e posicionamento de membros não funcionais, com aumento do risco de deformidades estruturadas.
Uso de ArmeoSpring® na reabilitação de paciente hemiplégico pós acidente vascular encefálico
Authors: Marques Jaqueline Covatti , Silva Larissa Russo Veloso e , Lima Thassia Cristina Farias , Souza Daniel Gottardo de , Barbosa Everton Horiquini
Published: February 2025

O Acidente Vascular Encefálico (AVE) é uma das causas que acometem significativamente a população em geral, essa condição duplica os registros de internações por doenças cerebrovasculares a cada década e se torna bastante evidente a partir dos 55 anos de idade. No Brasil, segundo dados do Sistema Único de Saúde do Ministério da Saúde, em 2009 foram registrados 160.621 casos de internações em decorrência de AVE e sua taxa de mortalidade nesse período foi de 51,8 óbitos a cada 100.000 habitantes acometidos. Com base na Agenda 2030 da Organização Mundial de Saúde para o Desenvolvimento Sustentável, existe um acordo de intenção dos países-membros para uma queda das taxas de mortalidade de 30% por doenças não transmissíveis, em especial as doenças cardiovasculares (DCV) (cardiopatia isquêmica e acidente vascular cerebral — AVE), câncer, doença respiratória e diabetes.
Variation in Likelihood of Undergoing Percutaneous Coronary Intervention for ST‐Segment–Elevation Myocardial Infarction Among US Hospitals
Authors: Nathan Ashwin S. , Kennedy Kevin F. , Reddy Kriyana P. , Fanaroff Alexander C. , Kolansky Daniel M. , Kobayashi Taisei J. , Khatana Sameed Ahmed M. , Dayoub Elias J. , Eberly Lauren , Rao Sunil V. , Mehran Roxana , Bhatt Deepak , Yeh Robert W. , Spertus John A. , Giri Jay
Published: February 2025

Background

There may be variability in willingness to perform percutaneous coronary intervention (PCI) in higher‐risk patients who present with ST‐segment–elevation myocardial infarction (STEMI). We sought to describe current treatment selection patterns and hospital‐level variability.

Methods and Results

We identified patients presenting with STEMI with a culprit lesion on coronary angiography between January 1, 2019, and March 31, 2023, using the NCDR (National Cardiovascular Data Registry) CPMI (Chest Pain–Myocardial Infarction) registry. We compared patient‐level characteristics of patients who did and did not undergo PCI at each hospital. There were 178 984 patients from 582 US hospitals presenting with STEMI who were included. Among patients with STEMI and a culprit lesion, 6180 did not undergo PCI (3.5%). Patients with a presentation of STEMI and a culprit lesion who did not undergo PCI were older (67 [interquartile range, 58–76]) years versus 62 ([interquartile range, 54–71] years,
P
<0.001), more likely to present with heart failure (15.0% versus 7.4%,
P
<0.001), and more likely to have cardiac arrest before arrival (9.7% versus 5.1%,
P
<0.001) than patients who underwent PCI. Patients who did not undergo PCI had higher predicted mortality rates (12.5%±17.9% versus 6.5%±11.5%,
P
<0.001) and observed mortality rates (21.7% versus 6.4%,
P
<0.001) compared with patients who underwent PCI.

Conclusions

There is variability in the percentage of patients with culprit lesions on invasive coronary angiography undergoing PCI for STEMI, with 3.5% of patients with STEMI not receiving PCI overall, and >5% of patients not undergoing PCI in a quarter of US hospitals. Differences in observed versus predicted mortality rates for patients who did or did not undergo PCI may highlight the effects of risk‐avoidant behavior.
Incremental Prognostic Value of Echocardiography Measures of Right Ventricular Systolic Function in Patients With Chronic Heart Failure
Authors: Gentile Francesco , Chianca Michela , Bazan Lorenzo , Sciarrone Paolo , Chubuchny Vlad , Taddei Claudia , Poggianti Elisa , Passino Claudio , Emdin Michele , Giannoni Alberto
Published: February 2025

Background

Tricuspid annular plane systolic excursion (TAPSE), Doppler tissue imaging–derived tricuspid lateral annular systolic wave velocity (S′), and right ventricular fractional area change (RV‐FAC) are the most widely used echocardiographic measures of right ventricular systolic function. This study aimed to compare the prognostic value of TAPSE, S′, and RV‐FAC in a large cohort of patients with chronic heart failure.

Methods

Consecutive outpatients with heart failure and left ventricular ejection fraction <50% on guideline‐recommended therapies undergoing echocardiography were followed up for the end point of cardiac and all‐cause death.

Results

Among 1590 patients (71±12 years, 77% men, left ventricular ejection fraction 34%±9%), 202 (13%) died from cardiac causes during a median follow‐up of 28 (interquartile range, 14–40) months. According to the recommended cut points for TAPSE (<17 mm), S′ (<9.5 cm/s), or RV‐FAC (<35%), right ventricular systolic dysfunction was found in 37%, 40%, and 35% of patients, respectively, with 21%, 31%, and 33% of discordant cases comparing TAPSE versus S′, TAPSE versus RV‐FAC, and S′ versus RV‐FAC. Both TAPSE <17 mm and RV‐FAC <35% were more accurate than S′ <9.5 cm/s in predicting the risk of cardiac death (
P
<0.001), and their combination showed incremental prognostic power (
P
<0.001). Adding S′ to the combination of TAPSE and RV‐FAC did not provide further incremental value (
P
=0.145). Similar findings were obtained when all‐cause death was considered as the end point.

Conclusions

In patients with chronic heart failure and left ventricular ejection fraction <50%, TAPSE, and RV‐FAC are more accurate than S′ in predicting the risk of cardiac and all‐cause death. Considering both RV‐FAC and TAPSE provides incremental prognostic value.