bluuebunny/crossref_metadata_2025 huggingface dataset:
Reflections of BILSEM Future Awareness Psychoeducation Program in Practice
Authors: Aydoğan Mustafa , Tanrıseven Işıl
Published: January 2025

Introduction: Gifted children can be characterized as the most important human resources in achieving a country's economic, social and cultural development goals. In our country, Science and Art Centers are among the institutions that have an important place in the development of gifted children. This study aims to examine student acquisitions and opinions regarding the “Future Awareness Psychoeducation Program” prepared by the Ministry of National Education to support the career development of gifted students who have been receiving education in BILSEM since 2021.
Method: In this study, a holistic single case design, one of the case study types, was used. The research group of this study consisted of 8th-grade students who attended the support education program at a Science and Art Center in the Tarsus district of Mersin in the 2022-2023 academic year. The research data were collected using the “Interview Form on Future Awareness Psychoeducation Program” and “Observation Form.” The data obtained were analyzed by descriptive analysis method through the MAXQDA Pro 2020 qualitative data analysis program.
Findings: According to the results of this study, it was observed that almost all gifted students achieved acquisitions of the Future Awareness Psychoeducation Program in terms of recognizing interests and talents, career adaptation skills, and goal setting. However, it was observed that some students could not explain the importance of taking responsibility for the future and not all of them could give an example of social entrepreneurship. The results showed that gifted students reached most of the acquisitions on psychological resilience; some of them did not reach some of them, but they mostly did not reach the learning agility acquisitions. In addition, it was observed that almost all of the students reached the acquisitions of recognizing professions and decision-making. However, some students could not express the importance of believing in themselves about what they can do in the future.
Discussion: Within the scope of this research, it was seen that the activities implemented in the Future Awareness Psychoeducation Program enabled students to get to know themselves, set goals, identify professions, make decisions and improve their career adaptation skills.
Influence of Adding High Flash Point, Special Jet Fuel for Brazilian Navy (QAV-5), in Brazilian Marine Gasoil (ODM), on Fuel Viscosity, Specific Gravity, Cetane Index and Lubricity
Authors: R. Louzeiro Camila , G. de Souza Cristiane , F. de Andrade Débora , A. d'Avila Luiz
Published: January 2025

The degradation of Type 5 aviation kerosene, used in navy aircraft, (QAV-5) during the storage
period was evaluated by thermal oxidation test (JFTOT) and current gum test. QAV-5 failed to
meet jet fuel specifications after 16 weeks of accelerated aging, due to compromised thermal
stability and substantial gum generation. Pure blends of QAV-5 and aviation kerosene and marine
diesel oil (QAV-5/ODM) in proportions of 25, 50 and 75% (v/v) were analyzed according to the
marine diesel oil (ODM) specification, in week zero and at intervals of four weeks throughout
the aging process. Fuel viscosity, specific gravity, cetane number and lubricity decreased as the
QAV-5 content in the mixture increased. The viscosity of QAV-5, however, increased with storage
time. The employment of pure QAV-5 diesel engines is not advisable unless the use of aviation
fuel is expressly permitted. By the fuel haze lubricity test (FLHT), QAV-5/ODM blends with up
to 88% (v/v) QAV-5 content can be used in diesel engines without damaging the fuel system.
However, confirmation by standard high frequency reciprocating rig (HFRR) testing would be
advisable for QAV-5/ODM mixtures with QAV-5 volumetric content above 75%.
Estuary salinity prediction using machine learning: case study in the Hau estuary in Mekong River, Vietnam
Authors: Nguyen Huu Duy , Dang Dinh Kha , Bui Quang-Thanh
Published: January 2025

The prediction of saltwater intrusion in estuaries plays an important role, supporting decision-makers or farmers in building strategies, and also, policies made for agricultural development and water resource management. The objective of this study is to develop machine learning models, namely gated recurrent unit (GRU), GRU-GWO (grey wolf optimiser), and GRU-SFO (sailfish optimiser algorithm) to predict saltwater intrusion for 1, 7, 15, and 30 days ahead in the Mekong estuary of Vietnam. Several statistical indices, namely root mean square error (RMSE), mean absolute error (MAE), and coefficient of determination (R2), were applied to evaluate the accuracy of the saltwater intrusion model. The results showed that the GWO and SFO optimisation algorithms successfully improved the accuracy of the GRU model to predict saltwater intrusion. For a one day forecast, the R2 value of the proposed models ranged from 0.89 to 0.91, for a seven day forecast, it ranged from 0.81 to 0.85, for a 15-day forecast, from 0.67 to 0.76, and for a 30-day forecast, from 0.52 to 0.55. The results indicated the ability of the GRU model to predict saltwater intrusion.
Oridonin Suppresses the Malignant Progression of Lung Cancer by Targeting S100A11
Authors: Luo Yulin , Li Jingjing , Chen Yao , Huang Yan , Luo Qi , Luo Qiang , Huang Qingqing , Huang Gang , Jin Mingming
Published: January 2025

Background:

Lung cancer (LC) is the second most lethal cancer and efficient
treatments are missing. Our understanding of the underlying pathogenic mechanisms remains
limited. Oridonin is a compound extracted from the Chinese herb Rabdosia rubescens
with anticancer properties. Nevertheless, its effects on LC and the underlying mechanisms
remain unknown.

Methods:

In the current research, A549 and Hcc1833 cells were treated with different
doses of oridonin, and cell proliferation and migration were detected using CCK8, EdU,
Transwell, and wound healing assays. A subcutaneous tumor and caudal vein metastasis
model was generated to verify the inhibitory effects of oridonin on Hcc1833 tumor
growth and metastasis in vivo. Proteomics analyses then were performed to examine the
regulatory mechanism. LiP-SMap combined with microscale thermophoresis and molecular
docking analyses were used to validate the relationship between oridonin and
S100A11.

Result:

Data showed that oridonin suppressed cell proliferation and migration depending
on dose and suppressed tumor growth and invasion. LiP-SMap and molecular docking
analyses confirmed that oridonin interacted with the Asn-53 residue of S100A11,
which inhibited the activation of oridonin. S100A11 overexpression reversed the inhibitory
effects of oridonin on cell proliferation and migration.

Conclusion:

In conclusion, the data indicate that oridonin suppresses LC malignant progression
by targeting S100A11.
Predicting Polymerase Chain Reaction Success: Integrating the K-Word Order Model, Physicochemical Properties Modeling of Double Bases, and
Support Vector Machine
Authors: Yan Long , Liu Yong , Yang Yan
Published: January 2025

Introduction:

Polymerase Chain Reaction (PCR) has been a pivotal scientific technique
since the twentieth century, and it is widely applied across various domains. Despite its
ubiquity, challenges persist in efficiently amplifying specific DNA templates.

Method:

While PCR experimental procedures have garnered significant attention, the analysis of
the DNA template, which is the experiment's focal point, has been notably overlooked. This
study addresses the uncertainty surrounding the amplification of DNA fragments using conventional
Taq DNA polymerase-based PCR protocols. The imperative need to characterize DNA
templates and devise a reliable method for predicting PCR success is underscored.

Result:

In this study, we formulate a 72-dimensional feature vector representing a DNA template
through the utilization of k-word order and modeling of physicochemical properties of double
bases. Subsequently, a Support Vector Machine (SVM) model is employed to assess PCR results.

Conclusion:

A jackknife cross-validation test is used to evaluate the anticipated success rates,
resulting in an overall accuracy of 95.77%. Sensitivity, specificity, and Matthew's Correlation
Coefficient (MCC) stand at 95.75%, 95.79%, and 0.915, respectively.
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A
Pharmacokinetic and Pharmacodynamic Study
Authors: Sundargowda Shruthi A , Kadiri Sunil Kumar
Published: January 2025

Background:

Hypertension, which affects 1.28 billion people globally aged 30 to 79, is characterized
by continuously high blood pressure (140/90 or more) and raises the risk of premature death. Losartan, an
angiotensin receptor blocker (ARB), is suggested for patients under the age of 55 who cannot take ACE inhibitors
as a first treatment option. Epilepsy, a chronic neurological illness marked by repeated seizures, affects
more than 50 million individuals worldwide and is the third most common chronic brain disorder. Both hypertension
and epilepsy are frequent chronic illnesses, with increased blood pressure greatly raising the risk of
epilepsy due to its relationship with cerebrovascular disease, doubling the risk when compared to people with
normal blood pressure.

Objective:

The effect on pharmacokinetic and pharmacodynamics of losartan on concomitant administration
with carbamazepine was investigated.

Materials and Methods:

Wistar rats of either sex, with a minimum of six animals per group, were used in the
investigation. The rats were treated with Losartan and Losartan-Carbamazepine for 30 days. Blood samples
were taken via retro-orbital plexus at 0, 1, 2, 4, 6, and 12 hours after treatment concluded, and they were subjected
to high-performance liquid chromatography for plasma analysis to calculate AUC, t1/2, and Clearance.
A pharmacodynamic evaluation was done by inducing hypertension in rats using a 10% fructose solution and
the effect of pretreated Losartan and Losartan-Carbamazepine on blood pressure was determined.

Results:

In the Losartan and Carbamazepine treated group, there was a reduction in the AUC and t1/2 and a reported
increase in the clearance value compared to Losartan alone treated rats. In fructose-induced hypertension
model to evaluate the effect of losartan and carbamazepine on BP showed an increase in mean arterial
pressure, plasma glucose, and a reduction in triglycerides level was noted in comparison to Losartan alone
treated rats indicating therapeutic failure of Losartan.

Conclusion:

Based on these studies, it is concluded that CBZ has reduced the effectiveness of losartan and
therefore, co-administration of these drugs should be avoided.
The Application of the Pyrazole Structure in the Structural Modification
of Natural Products
Authors: Sun Fu-Qun , Wang Ya-Lan , Sun Ke , Yue Fei-Xia , Sun Yun-Xia , Ju Jia-Hong , Jin Zhan-Hui , Shen Qing-Kun , Guo Hong-Yan , Liu Mei-Hui , Quan Zhe-Shan
Published: January 2025

Most natural products in nature have broad but not exceedingly good biological activities.
The pyrazole structure has been introduced into natural products due to its suitability for various
synthetic methods and its broad pharmacological activities. This article provides a detailed introduction to the anti-inflammatory, antibacterial, antifungal, antiviral, and anti-Alzheimer disease activities of pyrazole-modified natural product derivatives, particularly their anti-tumor activity. It is
worth noting that compared to lead compounds, most natural product derivatives modified with pyrazole exhibit excellent pharmacological activity. Some of these derivatives exhibit outstanding anti-tumor activity, with IC50 values reaching nanomolar levels. This review provides more research
directions and choices for future studies on natural products.
Chemoselectivity Profiling in the Alkylation of 2-Chloroethylurea Derivatives
with Secondary Amines
Authors: Wang Hongyin , Liang Yu , Yu Yida , Wang Yihao , An Ni , Cai Dong
Published: January 2025

The ureido moiety stands as one of the most regarded scaffolds in medicinal and organic
synthesis. In this study, we endeavored to synthesize a product containing tertiary amine moieties
through the nucleophilic substitution reaction of the 2-chloroethyl urea derivative with a secondary
amine, utilizing either inorganic bases, such as K₂CO₃ or organic bases like triethylamine as acidbinding
agents in diverse reaction media. Unfortunately, the reaction failed to yield the desired nucleophilic
substitution product in high yield, attributed to the reactivity of the 2-chloroethyl urea derivative.
The structures of potential impurities were elucidated based on comprehensive spectroscopic
data, including ¹H NMR, ¹³C NMR, HRMS, HMBC, and HSQC.
A Comprehensive Review: Synthesis and Pharmacological Activities of 1,3,4-Oxadiazole Hybrid Scaffolds
Authors: Lata Suman , Choudhary Lucky , Bharwal Ankita , Pandit Amit , Abbot Vikrant
Published: January 2025

Introduction: Heterocyclic derivatives, particularly those containing heteroatoms such
as oxygen and nitrogen, represent a significant portion of currently marketed drugs. Among these,
the aromatic heterocycle 1,3,4-oxadiazole, characterized by an N=C=O-linkage, stands out due to
its remarkable biological activities. These activities include anti-inflammatory, anti-cancer, antioxidant,
anti-tubercular, antiviral, anti-diabetic, and antibacterial effects. Notably, several commercially
available medications, such as tiodazosin, raltegravir, zibotentan, and nesapidil, incorporate this
structural motif.

Methods: This review compiles and analyzes existing synthetic methods for preparing 1,3,4-
oxadiazole and its derivatives. By examining various synthetic routes and methodologies, the review
provides a detailed overview of the strategies employed to generate these biologically active
compounds.

Results: The review highlights the potential of 1,3,4-oxadiazole derivatives in addressing the toxicity,
side effects, and drug resistance commonly associated with existing anticancer therapies. By
combining the 1,3,4-oxadiazole moiety with other heteroatoms, novel hybrid derivatives have been
synthesized, demonstrating enhanced pharmacological activities across various therapeutic areas.

Conclusion: This comprehensive review offers valuable insights into the synthesis and pharmacological
applications of 1,3,4-oxadiazoles. It serves as a crucial resource for researchers exploring
the development of new therapeutic compounds, with the ultimate goal of improving public health.
The review builds on existing literature from the last two decades to present an exhaustive examination
of the potential of 1,3,4-oxadiazole derivatives in drug development.
Molecular Mechanisms and Pathways of Mesenchymal Stem Cell-mediated Therapy in Brain Cancer
Authors: Singh Kuldeep , Singh Geetanjali , Gupta Jeetendra Kumar , Choudhary Alka N. , Kumar Arun , Jain Divya , Sharma Mukesh Chandra , Kumar Shivendra
Published: January 2025

Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach in
the treatment of brain cancer due to their unique biological properties, including their ability to
home tumor sites, modulate the tumor microenvironment, and exert anti-tumor effects. This review
delves into the molecular mechanisms and pathways underlying MSC-mediated therapy in
brain cancer. We explore the various signalling pathways activated by MSCs that contribute to
their therapeutic efficacy, such as the PI3K/Akt, Wnt/β-catenin, and Notch pathways. Additionally,
we discuss the role of exosomes and microRNAs secreted by MSCs in mediating anti-tumor effects.
The review also addresses the challenges and future directions in optimizing MSC-based
therapies for brain cancer, including issues related to MSC sourcing, delivery methods, and potential
side effects. Through a comprehensive understanding of these mechanisms and pathways, we
aim to highlight the potential of MSCs as a viable therapeutic option for brain cancer and to guide
future research in this field.
Beyond Dopamine: Novel Therapeutic Pathways for Parkinson's Disease Through Receptor Signaling
Authors: Bhushan Rashmi , Goel Falguni , Singh Shamsher
Published: January 2025

Parkinson's disease (PD) is a progressive neurological condition characterized by both
dopaminergic and non-dopaminergic brain cell loss. Patients with Parkinson's disease have tremors
as a result of both motor and non-motor symptoms developing. Idiopathic Parkinson's disease (idiopathic
PD) prevalence is increasing in people over 60. The medication L-dopa, which is now on the
market, merely relieves symptoms and has several negative effects. In this article, we highlight the
therapeutic potential of glucagon-like peptide-1, adenosine A2A, and cannabinoid receptors as attractive
targets for enhancing neuroprotection and reducing a variety of motor and non-motor symptoms.
Recent research has widened knowledge of new therapeutic targets and detailed cellular
mechanisms, providing invaluable insights into the essential roles of cannabinoid receptors, adenosine
A2A receptors, and glucagon-like peptide-1 receptors in PD pathogenesis and unique opportunities
for drug development for mankind globally.
Excess Pore Water Pressure Ratio Comparison from Empirical and Numerical Methods to Determine Liquefaction Potential in Palu, Central Sulawesi, Indonesia
Authors: Al Rahman Mukhlis Habib , Fathani Teuku Faisal , Wilopo Wahyu
Published: January 2025

Background

Palu is a city in Central Sulawesi Province with a very high level of seismic activity. The seismicity in Central Sulawesi is associated with the active movement of the Palu Koro fault. One of the most severe events occurred on September 28, 2018, which triggered liquefaction and a tsunami. This is also related to the lithology of Palu, which consists of alluvial deposits predominantly made up of sand.

Objective

This study compares excess pore water pressure values analyzed empirically and numerically to identify liquefaction potential. It aims to provide additional perspectives for engineers in designing buildings around the study area that are resistant to liquefaction.

Methods

Excess pore water pressure was analyzed using empirical and numerical methods to determine liquefaction potential. The empirical method used the equation by Yegian and Vitteli (1981), while the numerical method involved finite element analysis using the Plaxis 2D application and nonlinear analysis using DEEPSOIL v7.

Results

The results from the three methods of analyzing excess pore water pressure to determine liquefaction potential at the four borehole points showed differences. For the empirical method, using the equation by Yegian and Vitelli (1981), the results indicated that the layers with a pore pressure ratio (ru>0.8) were deeper than the finite element and non-linear methods.

Conclusion

The differences in methods result in varying outcomes in analyzing excess pore water pressure to identify liquefaction potential. The empirical method uses the peak value of Peak Ground Acceleration (PGA) to evaluate the entire soil profile, leading to a more generalized assessment. In contrast, the non-linear and finite element methods consider each layer's behavior under the applied seismic load, providing more detailed and similar results.
Investigation of the Prevalence of Chronic Pulmonary Effusion Causes and Response to Treatment (Pleurodesis) in Patients
Authors: Shirzadi Alireza , Ahmadinejad Izadmehr , Ahmadinejad Mojtaba , Hatami Saeed , Soltanian Ali , Ahmadinejad Yasmina
Published: January 2025

Background

Pleural effusion, the pathological accumulation of fluid in the pleural space, is widespread. This study investigates pleural effusion in terms of malignancy among patients referred to tertiary health care centers and evaluates the response rates to different pleurodesis techniques.

Methods

This cross-sectional study enrolled all patients with pleural effusion referred to a tertiary health care center. Laboratory data, including White Blood Cell count and differentiation (WBC), Hemoglobin levels (HB), Erythrocyte Sedimentation Rate (ESR), and biochemical analysis results of the pleural fluid (protein, glucose, and lactate dehydrogenase) were recorded. Data from pleural fluid cytopathological examination, including cell count, cell types, gram staining, and pleural fluid culture, were also documented. Patients undergoing pleurodesis were assessed for response rates, which were categorized as complete, partial, or no response based on clinical and radiological criteria. Collected data were subjected to statistical analysis.

Results

The study investigated 144 patients with chronic pleural effusion, with an average age of 47.59 years. Of these, 97 patients (66%) were male and 47 patients (34%) were female. The most common cause of chronic pleural effusion was malignancy, with a prevalence of 65.9%. Among patients treated with pleurodesis, the overall response rate was 78.4%, with chemical pleurodesis achieving a higher complete response rate (65%) compared to mechanical pleurodesis (55%). Other prevalent causes of chronic pleural effusion, in descending order, included heart failure, liver cirrhosis, chronic kidney failure, and unknown factors.

Conclusion

This study highlights malignancy and chronic heart failure as the predominant etiologies of chronic pleural effusion in a tertiary healthcare setting. Furthermore, it emphasizes the efficacy of pleurodesis techniques, with chemical pleurodesis demonstrating superior outcomes. These findings offer valuable insights into the pathogenesis and management of chronic pleural effusion.
Exploring the Therapeutic Potential of Benzimidazole Hybrids as Antimicrobial Agents: An In-Depth Analysis
Authors: Shukla Sugat , Azad Iqbal , Akil Mohd , Owais Mohammad , Siddiqui Benjamin , Verma Shikhar , Singh Kuldeep , Kumar Arun
Published: January 2025

Background:

Heterocyclic compounds play an essential role in biological sys-tems and occur widely in nature. They are fundamental in the development of pharma-ceuticals aimed at combating microbial infections and other biological activities. Phar-macological evaluations have demonstrated their efficacy against diverse bacterial strains. This study investigates the antimicrobial properties of various benzimidazole hy-brids. The findings highlight the significant influence of substituting nitrogenous scaf-folds with various heteroatoms on the potential development of new antimicrobial agents.

Objective:

This review article is expected to make a substantial contribution to the ad-vancement of efficacious antibacterial medications. The research's goal is to improve the efficacy of combating bacterial infections by utilizing the potent properties of benzimid-azole-based hybrid scaffolds. In the end, this will aid in reducing the global incidence of this contagious illness.

Methods:

Several nitrogen-containing heterocyclic compounds display substantial poten-tial as antibacterial agents. These compounds possess fused benzene and imidazole nu-clei. These nuclei could change the number of electrons they have, which in turn affects their physiochemical characteristics. The versatility of drugs arises from their capacity to interact with receptors in various modalities, which is a key factor in drug pharmacolog-ical screening. Benzimidazole-based hybrids have demonstrated a wide range of pharma-cological effects, including antibacterial, anti-HIV, anticancer, antimalarial, antiviral, an-tifungal, antioxidant, anti-inflammatory, and anti-tubercular activities.

Results:

Pyrazole, imidazole, oxazole, thiazole, indole, and benzimidazole are examples of compounds that include nitrogen species. These nitrogen-containing compounds en-gage in metabolic interactions with other molecules within the cell. Nevertheless, an over-abundance of reactive nitrogen species can cause cytotoxicity, causing harm to vital bio-logical macromolecules. But benzimidazole is traditionally the most effective, with a wide range of important qualities, including antibacterial, anti-HIV, anticancer, antima-larial, antiviral, antifungal, antioxidant, anti-inflammatory, and anti-tubercular activities.

Conclusion:

This study focuses on the efficacy of novel benzimidazole-based hybrid scaffolds in inhibiting microbial growth or eradicating microorganisms. The study pri-marily focuses on recent studies carried out from 2009 to 2024. The study highlights the effectiveness of different benzimidazole-based hybrids using MIC values. More in-depth studies also show that adding electron-withdrawing groups (EWGs) to the nitrogenous framework might make them more effective. Further research is necessary to design strong, least-toxic benzimidazole-based hybrids that can either kill or inhibit multidrug-resistant (MDR) bacteria.
Research on ACC Control Strategy for Electric Vehicles Considering Cut-in Behavior
Authors: Runhua Li , Huanhuan Zhang , Shengli Hu , Mengyi Zhang
Published: January 2025

Background:

Current adaptive cruise control systems primarily focus on the main target
vehicle in the primary lane. However, there may be a delay in updating their targets after a side vehicle
merges. This delay can impede the effective utilization of driving data from merging side vehicles,
resulting in delayed responses and an increased risk of collision.

Objective:

Aiming at the problem of untimely control of traditional adaptive cruise control systems
in cut-in scenarios, the authors establish a parallel model and collision analysis and design the control
strategy of adaptive cruise under parallel behavior to improve the safety, following, and comfort
of ACC.

Methods:

Initially, the vehicle model provided by CarSim is utilized and the power system parameters
are adjusted to match the dynamic performance index. The permanent magnet synchronous
motor model is then simplified to create an electric vehicle model. Following this, the cruise control
system is designed using a PID control method, incorporating a hierarchical control structure.
Simultaneously, a cut-in model characterized by sinusoidal acceleration is established, and a collision
avoidance strategy based on cut-in behavior is formulated. Building on this foundation, an
adaptive cruise control strategy is developed that takes cut-in behavior into account.

Results:

A test scenario utilizing the CarSim and Simulink co-simulation platforms was developed
to simulate and validate the conditions for mode switching and lane cut-in. The ACC system, considering
cut-in behavior recognition, demonstrated an ability to control the lead vehicle approximately
1 second earlier than traditional ACC systems. Notably, the distance error improved from -
0.1039 m to 0.040 m, the absolute value of velocity error decreased from 2.65 m/s to 2.02 m/s, the
absolute value of main vehicle acceleration reduced by 34%, and the jerk response in acceleration
diminished by approximately 14%.

Conclusion:

The proposed multi-objective cooperative adaptive cruise control system, which considers
cut-in behavior, is effective.
MEM-8X8: A Multimodal Framework for Emotion Classification and Mismatch Analysis Using the ICE Dataset
Authors: Sharma Rishabh , Kukreja Vinay
Published: January 2025

Aims:

The study aims to evaluate visual and textual emotions, understand mismatches
and overall explainability using the proposed multimodal emotion mapping-8X8
(MEM-8X8) framework on the developed IndiComics Emotion (ICE) dataset.

Background:

Understanding and aligning emotions in the visual and linguistic modes of comics
is difficult due to their stylized and abstract nature. However, existing unimodal methods
fail to obtain the interplay between text and visuals, highlighting the requirement for multimodal
techniques for advanced emotion classification and mismatch assessment.

Objective:

This study proposes a robust MEM-8X8 framework backed by VisualBERT to classify
and analyze the ICE dataset into visual and nuanced textual emotions, analyze mismatches,
and provide comprehensive explainability with advanced interpretation tools.

Methods:

The proposed MEM-8X8 framework combines the Vision Transformers (ViT) and
the bidirectional encoder representations from transformers (BERT) embeddings to evaluate
the multimodal emotion classification and mapping using VisualBERT. Chi-square tests are
conducted to analyze if the given emotions are in agreement, mismatched, and statistically significant.
Along with this, the proposed model has outperformed its performance when compared
with existing models.

Results:

The VisualBERT model outperformed the unimodal ViT and BERT with an average
accuracy of 93.5% across all 8 emotions and a gain of 6.5% over single-modality approaches.
The best agreement score of 93.6% has been recorded for the “Neutral” emotion. In comparison,
the “Angry-Disgust” emotion pair has the highest mismatch frequency of 18.4%, highlighting
challenges in their alignment across visual and textual modalities in comics.

Conclusion:

The proposed VisualBERT-based MEM-8X8 framework performs better in classifying
8 emotions, addressing mismatch alignment across visual and textual modalities. This
study lays the foundation for future comics and multimodal emotion recognition analysis advancements.
Improving the Nutritional, Antioxidant, and Sensory Characteristics of Ready-to-use Yellow Sauce Condiments
Authors: Foudjo Brice Ulrich Saha , Nkweda Carole Yankam , Kuagny Ronald Blaise Mouafo , Kansci Germain
Published: January 2025

Objectives:

The study aimed to improve the nutritional, antioxidant, and sensory attributes of yellow sauce spice blends.

Methods:

A qualitative survey among housewives, traders, and restaurant owners identified commonly used spice blends for yellow sauce recipes. The blend with the highest sensory acceptability index was used as the base for modeling with a Simplex Lattice mixture design. Variables included the nature and proportion of spices, with responses being total phenolic compound content and sensory acceptability index. The resulting formulation was tested for in vitro antioxidant activities (TAC, FRAP, DPPH, and °OH), water and mineral contents (Fe, Cu, P, Mg, and Ca), and physical and functional properties (color, density, water, and oil absorption capacity).

Results:

The survey identified four spice blend recipes, with the most accepted having a sensory acceptability index of 0.7. Optimization produced a blend of 18% Afrostyrax lepi-dophyllus, 8% Piper guineense, 38% Tetrapleura tetraptera, 31% Dichrostachys glometara, and 5% Xylopia aethiopica (Dunal) A. riche. This blend exhibited fairly pleasant acceptabil-ity (index = 0.80) and a phenolic compound content of 1398.69 Eq mg AG/100g of DM. The developed formulation showed higher levels of zinc (19 ppm) and iron (234 ppm), as well as superior Total Antioxidant Capacity (310.04 Eq mg AG/100g DM) and °OH inhibition (75.32 μg/ml) compared to the survey-derived formulation.

Conclusion:

The modeling of the spice blends improved some sensory, antioxidant, and mineral properties, ensuring consistent quality in the yellow sauce condiments.
Methodology for determining freight indices
Authors: Sitov A. N. , Speranskaya Y. A. , Slican A. E.
Published: January 2025

The paper considers the issues of quantifying the indicator of the freight market conjuncture and analyzes some basic principles used in calculating freight indices. It is noted that the current geopolitical situation has a significant impact on the general behavior of the global freight market and inevitably leads to temporary restrictions on the functioning of the Russian market, which objectively determines the need to calculate domestic indices based on their own methods. The existing world practice of determining freight indices is considered, as well as the features of the Russian freight market as an integral part of the world market. It is emphasized that the nomenclature of transported goods, the geography of transportation and the parameters of the fleet used are radically different from the world ones, which makes them irrelevant for Russian shipowners mastering export cargo flows from Russia and also that foreign freight indexes are only informative and cannot be used in practical work. The paper shows the structure of the formation of freight rates and identifies the main components of the carrier’s expenses. The structure of the freight rate is the basis for the formation of the proposed methodology for calculating freight indices. The criteria for determining the specific weights of individual sectors of the freight market are considered. The conclusions drawn in the conducted research are supported by analytical data presented in graphical form. The practical use of the presented methodology will allow interested parties involved in transportation to make informed management decisions.
Development of a test laboratory stand with a marine hot-water boiler
Authors: Stepanov N. E. , Karlina E. P. , Khomenko T. V.
Published: January 2025

The article deals with the issues of design and construction of a laboratory stand of a ship boiler plant based on Kiturami TURBO17 boiler, located in the laboratory “Ship Boiler and Steam Generating Plants” of the Federal State Budgetary Educational Institution of Higher Education “Astrakhan State Technical University”. The laboratory stand considered in the paper, made in accordance with the requirements of the International Convention on Standards of Training, Certification and Watchkeeping for Seafarers (STCW 78), was developed for scientific research and training of students. The article presents a comparative analysis of the laboratories of higher educational institutions, graduating specialists in the specialty 26.05.06 “Operation of ship power plants”. The description of the main components of the stand including its circuit diagram is given. It is noted the importance of laboratory stands, which are close to the ship’s performance, for the training of specialists. It is emphasized that this laboratory installation allows to conduct laboratory and practical classes aimed at providing students with theoretical knowledge and practical skills. It is noted that graduates should know the basic principles of operation and design elements of ship power plants, including boiler plants and their servicing systems, as well as have theoretical knowledge of thermodynamics, hydromechanics, be able to carry out calculations in thermal cycles, heat transfer processes, heat balance. The developed laboratory test bench can be used in the study of disciplines “Ship Boiler and Steam Generating Units”, “Operation of Ship Boiler and Steam Generating Units”, “Ship Auxiliary Mechanisms, Systems and Devices”, “Automated Control Systems of Ship Power Plants”, as well as for scientific research. The project on creation of the laboratory stand can be implemented for training of specialists in other specialized universities of the country.
Analysis of the implementation of the Merdeka Curriculum policy in senior high schools: A case study on the practice level of learning
Authors: Atmawidjaja Rd. Heri , Budiarti Erna , Jannah Ratu Roihatul , Chaedar Al
Published: January 2025

The Merdeka Curriculum Policy is a strategic step in Indonesia's educational reform, and this study is a collaborative effort to understand its implementation at the Senior High School (SMA) level. We aim to conduct an in-depth analysis, with particular attention to the process of understanding, application, and its impact on teaching and learning activities. The research employs a qualitative approach using data collection techniques such as field observations, in-depth interviews, and document analysis. The primary respondents are teachers, students, and school staff actively involved in the policy implementation, making this a truly inclusive and comprehensive study. The findings reveal that implementing the Merdeka Curriculum Policy in high schools faces challenges, such as inconsistent understanding of the policy among teachers, the need for ongoing training to enhance teacher competencies, and infrastructure limitations that hinder optimal application. Nevertheless, notable successes include increased creativity in learning, active student engagement in learning processes, and the emergence of innovations in teaching methods. Further analysis indicates that active teacher participation and managerial support from the school are critical success factors in implementing this policy. This research is not just an academic exercise but a practical guide for the development of educational policies. By providing insights into the challenges and opportunities of implementing the Merdeka Curriculum, we aim to empower policymakers with the knowledge to design more effective implementation strategies. This study also serves as a beacon of hope for other schools facing similar situations, offering practical guidance and enriching the academic literature on the dynamics of educational policy in Indonesia, particularly at the high school level.
Gap The Series: peran media terhadap persepsi hingga solidaritas fandom lesbian di Indonesia
Authors: Hafifah Helena Nuryatul
Published: January 2025

AbstrakMedia memiliki peran besar dalam mempengaruhi hadirnya media massa. Berkaitan dengan itu viralnya serial GAP: The Series menjadi fenomena yang menarik untuk diteliti. GAP The Series merupakan serial Girls Lover Thailand pertama yang berhasil menarik perhatian beberapa negara termasuk Indonesia. Dalam kajian ini melihat bagaimana budaya viralitas dan media saling berkaitan yang tentunya  berpengaruh terhadap persepsi masyarakat Indonesia baik bagi mereka yang awalnya tidak tahu maupun yang sudah berada di komunitas tersebut kemudian menjadi suka dan membentuk fandom. Melalui pendekatan kualitatif, analisis konten media peneliti melihat ada indikator  perubahan dalam persepsi secara umum, keterlibatan kelompok marginal secara khusus, dan solidaritas di antara fandom lesbian pada segmentasi khusus GAP The Series. Temuan menunjukkan bahwa media ini tidak hanya mempengaruhi pandangan masyarakat tetapi juga memainkan peran penting dalam memperkuat identitas dan solidaritas kelompok tersebut.Kata kunci: the series, media, persepsi, solidaritas, fandom lesbian Abstract The media has a big role in influencing the presence of mass media. In this regard, the virality of the GAP: The Series series is an interesting phenomenon to research. GAP The Series is the first Thai Girls Lover series that has managed to attract the attention of several countries including Indonesia. In this study, we look at how virality culture and media are interrelated, which of course affects the perception of Indonesian society, both for those who initially do not know and those who are already in the community, then become likes and form a fandom. Through a qualitative approach, the researcher analyzed media content and saw that there were indicators of changes in perception in general, the involvement of marginalized groups in particular, and solidarity among lesbian fandoms in the special segmentation of GAP The Series. The findings show that this media not only influences people's views but also plays an important role in strengthening the identity and solidarity of the group. Keywords: the series, media, perception, solidarity, lesbian fandom
Financial literacy as a key component of an educational strategy: analysis and recommendations
Authors: Pyanova N. V. , Stolyarova E. A. , Pyanov R. R. , Kryzhanovskaya O. A.
Published: January 2025

Relevance. The development and expansion of the sphere of financial relations in modern conditions is being transformed under the influence of a number of factors that determine new paradigms and approaches to financial resource management. Financial literacy is becoming a key factor in a successful life, and the need to implement it in educational strategies is becoming especially urgent. The increasing number of financial products and services, as well as the spread of digital technologies, require young people to be able to make informed financial decisions. A low level of financial literacy can lead to debt problems, improper management of resources and lack of savings, which leads to a decrease in the standard of living.

The purpose of this article is to analyze the current state of financial literacy implementation in educational strategies.

Objectives: to assess the level of financial literacy, to explore methods of improving the level of financial literacy, to identify the impact of financial literacy on decision-making and to deduce possible problems and threats.

Methodology. The research methodology includes empirical and analytical methods, and statistical analysis is also used, revealing the features and level of development of financial literacy.

Results. During the analysis, it was revealed that there are many methods to improve the level of financial literacy of the population. However, it is necessary to begin acquaintance with financial resources from an early age in order to prevent the formation of an irresponsible attitude towards money.

Conclusions. The results of the study showed that financial literacy is an essential component of an educational strategy that contributes to the formation of responsible citizens and consumers. It is recommended to apply a systematic approach to financial literacy training, which includes not only theoretical knowledge, but also practical skills.
Socio-cultural portrait of the Kursk region in the context of modern modernization processes (based on the materials of a sociological study)
Authors: Zarubina K. A. , Shishkareva T. N.
Published: January 2025

The relevance of the study of the socio-cultural portrait of the Kursk region is due to the need to identify new and clarify old directions for the implementation of priority national projects, ways to modernize social institutions, as well as improve the welfare of provincial society and the investment image of the subject in the context of regional socio-cultural changes of modernity in order to ensure sustainable development not only of a single region, but also of the Russian state as a whole. Also, the conclusions obtained in the work are actualized by the lack of the latest modern research on this problem.

The purpose of the study is to determine the features of the socio–cultural characteristics and potential of the Kursk region in modern conditions on the basis of sociological research data.

Objectives: to diagnose the state of the standard of living and social well-being of the population of the Kursk region; to analyze the cultural potential, political activity of the population of the region; to determine the specifics of the socio-cultural characteristics of the Kursk region; to formulate proposals to improve the quality of life of the population of the region.

Methodology. The following methods of scientific cognition were used in the study: the comparative method, the method of questioning in the form of a questionnaire, the method of analysis, synthesis, systematization and generalization.

Results. The article examines the main spheres of life of the population of the Kursk region: the socio-cultural sphere, the political activity of the inhabitants of the region, the financial situation of the Kuryans. According to the sociological research, the attractive and unattractive features of the region have been identified, the region's place in terms of human development among other subjects of the country. An assessment of certain problematic issues of the life of the local population has been obtained.

Conclusions. It has been established that the Kursk region has significant potential for development, and a number of problems have also been identified in certain areas of the region's life (from medical care to the precarious financial situation of residents). To resolve these problems, we consider it necessary to adjust certain areas of the internal policy of the region, including through the implementation of priority national projects, by modernizing some social processes with the help of legal, organizational and managerial tools in the context of regional socio-cultural changes.
Development and Validation of a Predictive Model Based on Serum Silent Information Regulator 6 Levels in Chinese Older Adult Patients: Cross-Sectional Descriptive Study
Authors: You Yuzi , Liang Wei , Zhao Yajie
Published: January 2025

Background

Serum levels of silent information regulator 6 (SIRT6), a key biomarker of aging, were identified as a predictor of coronary artery disease (CAD), but whether SIRT6 can distinguish severity of coronary artery lesions in older adult patients is unknown.

Objectives

This study developed a nomogram to demonstrate the functionality of SIRT6 in assessing severity of coronary artery atherosclerosis.

Methods

Patients aged 60 years and older with angina pectoris were screened for this single-center clinical study between October 1, 2022, and March 31, 2023. Serum specimens of eligible patients were collected for SIRT6 detection by enzyme-linked immunosorbent assay. Clinical data and putative predictors, including 29 physiological characteristics, biochemical parameters, carotid artery ultrasonographic results, and complete coronary angiography findings, were evaluated, with CAD diagnosis as the primary outcome. The nomogram was derived from the Extreme Gradient Boosting (XGBoost) model, with logistic regression for variable selection. Model performance was assessed by examining discrimination, calibration, and clinical use separately. A 10-fold cross-validation technique was used to compare all models. The models’ performance was further evaluated on the internal validation set to ensure that the obtained results were not due to overoptimization.

Results

Eligible patients (n=222) were divided into 2 cohorts: the development cohort (n=178) and the validation cohort (n=44). Serum SIRT6 levels were identified as both an independent risk factor and a predictor for CAD in older adults. The area under the receiver operating characteristic curve (AUROC) was 0.725 (95% CI 0.653‐0.797). The optimal cutoff value of SIRT6 for predicting CAD was 546.384 pg/mL. Predictors included in this nomogram were serum SIRT6 levels, triglyceride glucose (TyG) index, and apolipoprotein B. The model achieved an AUROC of 0.956 (95% CI 0.928‐0.983) in the development cohort. Similarly, in the internal validation cohort, the AUROC was 0.913 (95% CI 0.828‐0.999). All models demonstrated satisfactory calibration, with predicted outcomes closely aligning with actual results.

Conclusions

SIRT6 shows promise in predicting CAD, with enhanced predictive abilities when combined with the TyG index. In clinical settings, monitoring fluctuations in SIRT6 and TyG may offer valuable insights for early CAD detection. The nomogram for CAD outcome prediction in older adult patients with angina pectoris may aid in clinical trial design and personalized clinical decision-making, particularly in institutions where SIRT6 is being explored as a biomarker for aging or cardiovascular health.