bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of COVID-19 in children affected by allergic rhinoconjunctivitis and asthma: results from the second “SIAIP rhinosinusitis and conjunctivitis committee” survey
Authors: Brindisi Giulia , Zicari Anna Maria , Parisi Giuseppe Fabio , Diaferio Lucia , Indolfi Cristiana , Marchese Giuseppe , Ghiglioni Daniele Giovanni , Umano Giuseppina Rosaria , Klain Angela , Marseglia Gian Luigi , Del Giudice Michele Miraglia
Published: January 2022

Background

The role of allergic sensitization seems to be protective against SARS CoV2 infection. The aim of this study was to evaluate, using online surveys, the impact of COVID-19 on Italian allergic children, comparing the prevalence of AR and asthma symptoms between the first and second pandemic wave.

Methods

Both surveys were emailed to Italian pediatricians in April 2020 (first survey) and in March 2021 (second survey). The first one was related to the impact of COVID-19 and the most frequently reported symptoms. The second one was superimposed on the previous one, taking into account some additional aspects in the management of disease.

Results

A total of 99 pediatricians participated in the first survey and 267 in the second one. The first survey showed that, asthma and allergic rhinoconjunctivitis prevalence was mostly between 0 and 20% throughout the country. The second survey showed a lower prevalence of both diseases nationwide in comparison to the first one. Comparing the two surveys, statistically significant differences were reported only in the distribution of asthma prevalence in Southern Italy while no differences were highlighted in the North and in the Center. Finally regarding allergic rhinoconjunctivitis prevalence, no differences were noticed nationwide.

Conclusions

Allergic rhinoconjunctivitis and asthma, if under control, did not represent risk factors for the susceptibility to SARS CoV2. Therefore, it is strongly recommended to continue therapies during COVID-19 outbreak, according to the international guidelines. However, being COVID-19 a new disease, actual knowledge will undergo continuous improvements over time.
Universal annotation of the human genome through integration of over a thousand epigenomic datasets
Authors: Vu Ha , Ernst Jason
Published: January 2022

Background

Genome-wide maps of chromatin marks such as histone modifications and open chromatin sites provide valuable information for annotating the non-coding genome, including identifying regulatory elements. Computational approaches such as ChromHMM have been applied to discover and annotate chromatin states defined by combinatorial and spatial patterns of chromatin marks within the same cell type. An alternative “stacked modeling” approach was previously suggested, where chromatin states are defined jointly from datasets of multiple cell types to produce a single universal genome annotation based on all datasets. Despite its potential benefits for applications that are not specific to one cell type, such an approach was previously applied only for small-scale specialized purposes. Large-scale applications of stacked modeling have previously posed scalability challenges.

Results

Using a version of ChromHMM enhanced for large-scale applications, we apply the stacked modeling approach to produce a universal chromatin state annotation of the human genome using over 1000 datasets from more than 100 cell types, with the learned model denoted as the full-stack model. The full-stack model states show distinct enrichments for external genomic annotations, which we use in characterizing each state. Compared to per-cell-type annotations, the full-stack annotations directly differentiate constitutive from cell type-specific activity and is more predictive of locations of external genomic annotations.

Conclusions

The full-stack ChromHMM model provides a universal chromatin state annotation of the genome and a unified global view of over 1000 datasets. We expect this to be a useful resource that complements existing per-cell-type annotations for studying the non-coding human genome.
scDALI: modeling allelic heterogeneity in single cells reveals context-specific genetic regulation
Authors: Heinen Tobias , Secchia Stefano , Reddington James P. , Zhao Bingqing , Furlong Eileen E. M. , Stegle Oliver
Published: January 2022

While it is established that the functional impact of genetic variation can vary across cell types and states, capturing this diversity remains challenging. Current studies using bulk sequencing either ignore this heterogeneity or use sorted cell populations, reducing discovery and explanatory power. Here, we develop scDALI, a versatile computational framework that integrates information on cellular states with allelic quantifications of single-cell sequencing data to characterize cell-state-specific genetic effects. We apply scDALI to scATAC-seq profiles from developing F1Drosophilaembryos and scRNA-seq from differentiating human iPSCs, uncovering heterogeneous genetic effects in specific lineages, developmental stages, or cell types.
Atypical skin manifestation in severe acute chikungunya infection in a pregnant woman: a case report
Authors: Benjamanukul Saovanee , Chansaenroj Jira , Chirathaworn Chintana , Poovorawan Yong
Published: January 2022

Introduction

Patients with chikungunya virus infection commonly present with fever, skin rash, and severe joint pain. The vesiculobullous rash is rare in adults but common in infants. In addition, septic shock and acute respiratory distress syndrome are rare complications of atypical and severe acute chikungunya infection.

Case presentation

We report the presence of an 18-year-old Thai female, at 31 weeks gestation, with fever, maculopapular rash, and polyarthritis. The rash later progressed to a vesiculobullous pattern, and she developed septic shock and acute respiratory distress syndrome. Skin biopsy and blood were positive for chikungunya virus RNA. The patient was intubated with a mechanical ventilator and subsequently fully recovered.

Conclusion

Atypical skin manifestation and severe acute disease is likely due to immune response attenuation in pregnancy. The possibility of progression to severe or atypical disease in pregnant women suffering chikungunya should always be considered.
End-to-End provenance representation for the understandability and reproducibility of scientific experiments using a semantic approach
Authors: Samuel Sheeba , König-Ries Birgitta
Published: January 2022

Background

The advancement of science and technologies play an immense role in the way scientific experiments are being conducted. Understanding how experiments are performed and how results are derived has become significantly more complex with the recent explosive growth of heterogeneous research data and methods. Therefore, it is important that the provenance of results is tracked, described, and managed throughout the research lifecycle starting from the beginning of an experiment to its end to ensure reproducibility of results described in publications. However, there is a lack of interoperable representation of end-to-end provenance of scientific experiments that interlinks data, processing steps, and results from an experiment’s computational and non-computational processes.

Results

We present the “REPRODUCE-ME” data model and ontology to describe the end-to-end provenance of scientific experiments by extending existing standards in the semantic web. The ontology brings together different aspects of the provenance of scientific studies by interlinking non-computational data and steps with computational data and steps to achieve understandability and reproducibility. We explain the important classes and properties of the ontology and how they are mapped to existing ontologies like PROV-O and P-Plan. The ontology is evaluated by answering competency questions over the knowledge base of scientific experiments consisting of computational and non-computational data and steps.

Conclusion

We have designed and developed an interoperable way to represent the complete path of a scientific experiment consisting of computational and non-computational steps. We have applied and evaluated our approach to a set of scientific experiments in different subject domains like computational science, biological imaging, and microscopy.
Electronic cigarettes as a harm reduction strategy among patients with COPD: protocol for an open-label two arm randomized controlled pilot trial
Authors: Stevens Elizabeth R. , Lei Lei , Cleland Charles M. , Vojjala Mahathi , El-Shahawy Omar , Berger Kenneth I. , Kirchner Thomas R. , Sherman Scott E.
Published: January 2022

Background

Smoking cessation is the most effective means of slowing the decline of lung function associated with chronic obstructive pulmonary disease (COPD). While effective smoking cessation treatments are available, they are underutilized and nearly half of people with COPD continue to smoke. By addressing both nicotine and behavioral dependence, electronic cigarettes (EC) could help people with COPD reduce the harm of combustible cigarettes (CC) through reductions in number of Cigarettes per Day (CPD) or quitting CC completely. The purpose of this pilot study is to identify barriers and facilitators to the use of and assess the preliminary effectiveness of EC as a harm reduction strategy among people with COPD.

Methods

In an open-label two-arm randomized controlled trial pilot study, 60 patients identified as smokers with a COPD diagnosis via electronic health records from a large urban health center are randomized in a 1:1 ratio to either standard care [counseling + nicotine replacement therapy (NRT)] or counseling + EC. The NRT arm will receive nicotine patches and nicotine lozenges for 12 weeks. The EC arm will receive EC for 12 weeks. Both cohorts will receive counseling from a licensed mental health counselor. Using ecological momentary assessment, participants will report their use of CC in both arms and EC use in the EC arm daily via text message. Primary outcomes will be feasibility and acceptability of intervention, and secondary outcomes will be reduction in CPD and change in COPD symptoms as measured by COPD Assessment Tool (CAT) score at 12-weeks. EC displacement of CC. To explore attitudes towards the use of EC as a harm-reduction strategy for patients with COPD, interviews will be performed with a sample of participants from both study arms.

Discussion

Despite decades of availability of smoking cessation medications, nearly half of people with COPD still smoke. This study aims to address the unmet need for feasible and effective strategies for reducing CC use among those with COPD, which has the potential to significantly improve the health of people with COPD who smoke.

Trial RegistrationClinicalTrials.gov Identifier: NCT04465318.
Factors affecting test anxiety: a qualitative analysis of medical students’ views
Authors: Wadi Majed , Yusoff Muhamad Saiful Bahri , Abdul Rahim Ahmad Fuad , Lah Nik Ahmad Zuky Nik
Published: January 2022

Background

Medical students are vulnerable to test anxiety (TA), which impacts their professional lives and jeopardizes the optimal health care of their patients. The qualitative exploration of TA among medical students is crucial to understanding the problem. Hence, this study examined medical students’ insights into TA and their suggestions on how to reduce it.

Methods

We conducted a phenomenological study on medical students at a public university. We utilized focus group discussions (FGDs) to investigate their experiences of TA. The FGDs were transcribed verbatim, and these transcripts were analyzed using Atlas.ti software. The thematic analysis followed the recommended guidelines.

Results

Seven FGD sessions were conducted with 45 students. Three major themes emerged: the students, their academic resources, and the examiner. Each theme comprised mutually exclusive subthemes. The “students” theme was divided into negative vs. positive thoughts and self-negligence vs. self-care, “academic recources” into heavy curriculum vs. facilitative curricular aids, and “examiner” into criticism vs. feedback and strict vs. kind approaches.

Conclusion

This study provides a solid foundation for policymakers and decision makers in medical education to improve current assessment practices and student well-being. Medical students will be able to significantly alter and reduce TA if they are provided with additional psychological support and their examiners are trained on how to deal with examinees.
A comparative study: rural versus urban children as regard exposure to organophosphorus pesticides using cholinesterase enzyme activity
Authors: Mohamed Yasmen A. , Meabed Mohamed Hussien , Abougaba Khadiga Mohamed , Sayed Fatma Ali , Welson Nermeen N. , Ibrahim Raghda Ebaid
Published: January 2022

Background

The uncontrolled long-term exposure to organophosphorus (OP) pesticides is hazardous to health especially in children. The present study aimed to determine the acetyl cholinesterase enzyme serum level in exposure and non-exposure children groups, to explore other clinical and laboratory outcomes of organophosphorus pesticides exposure on children living in rural versus urban areas, and to establish the hemotoxic alterations as a result of the exposure. A ninety clinically free children—forty-five from rural areas and forty-five children from urban areas—were assessed, and the clinical and laboratory effects of their exposure to organophosphorus pesticides were evaluated via measuring acetyl cholinesterase (AChE) enzyme activity.

Results

Significant differences between the two areas of residence were found in weight %, visits to the field, eating vegetables without washing, presence of insecticides at home, and previous organophosphorus pesticides toxicity of the patients and their families. Eye, respiratory, cardiac, nervous, muscle, gastrointestinal, and urinary symptoms were more common in the rural residence group which shows more exposure to pesticides. The mean level of the AChE enzyme was less in the rural residence group than the other one, and it showed significant correlations with the anemia indicating parameters. A weak positive correlation was found with platelets count.

Conclusions

Chronic organophosphorus toxicity that is more prevalent in rural areas may result in many transient neglected symptoms, unrevealed acetyl cholinesterase (AChE) enzyme deficiency, anemia, and thrombocytopenia. Acetyl cholinesterase enzyme serum level can be used as a screening test for organophosphorus pesticides exposure.
Polygenic Ara-C Response Score Identifies Pediatric Patients With Acute Myeloid Leukemia in Need of Chemotherapy Augmentation
Authors: Elsayed Abdelrahman H. , Cao Xueyuan , Mitra Amit K. , Wu Huiyun , Raimondi Susana , Cogle Christopher , Al-Mansour Zeina , Ribeiro Raul C. , Gamis Alan , Kolb Edward Anders , Aplenc Richard , Alonzo Todd A. , Meshinchi Soheil , Rubnitz Jeffrey , Pounds Stanley , Lamba Jatinder K.
Published: January 2022

PURPOSE

To establish a patient-specific polygenic score derived from cytarabine (ara-C) pathway pharmacogenomic evaluation to personalize acute myeloid leukemia (AML) treatment.

MATERIALS AND METHODS

Single nucleotide polymorphisms (SNPs) in the ara-C-pathway genes were analyzed with outcome in patients from the multicenter-AML02 trial (N = 166). Multi-SNP predictor modeling was used to develop 10-SNP Ara-C_SNP score (ACS10) using top SNPs predictive of minimal residual disease and event-free survival (EFS) from the AML02-cohort and four SNPs previously associated with ara-C triphosphate levels in the AML97 trial. ACS10 was evaluated for association with outcomes in each clinical trial arms: the standard low-dose ara-C (LDAC, n = 91) and augmented high-dose ara-C (HDAC, n = 75) arms of AML02 and the standard Ara-C, daunorubicin and etoposide (ADE) (n = 465) and the augmented ADE + gemtuzumab ozogamicin (GO; n = 466) arms of AAML0531 trial.

RESULTS

In the standard LDAC-arm of AML02 cohort, the low-ACS10 score group (≤ 0) had significantly worse EFS (ACS10 low v high hazard ratio [HR] = 2.81; 95% CI, 1.45 to 5.43; P = .002) and overall survival (OS; HR = 2.98; 95% CI, 1.32 to 6.75; P = .009) compared with the high-ACS10 group (score > 0). These results were validated in the standard-ADE arm of AAML0531, with poor outcome in the low-ASC10 group compared with the high-ACS10 group (EFS: HR = 1.35, 95% CI, 1.04 to 1.75, P = .026; OS: HR = 1.64, 95% CI, 1.2 to 2.22, P = .002). Within the augmented arms (AML02-HDAC and AAML0531-ADE + GO), EFS and OS did not differ between low- and high-ACS10 score groups. In both cohorts, patients with low-ACS10 consistently showed a 10-percentage point improvement in 5-year EFS with augmented therapy (AML02-HDAC or AAML0531-ADE + GO arms) than with standard therapy (AML02-LDAC or AAML0531-ADE arms).

CONCLUSION

Patients with low-ACS10 score experienced significantly poor outcome when treated on standard regimen. Augmentation with either high-dose ara-C or GO addition improved outcome in low-ACS10 group. A polygenic ACS10 score can identify patients with unfavorable pharmacogenetic characteristics and offers a potential for an elective augmented therapy option.
Exercise Recommendation for People With Bone Metastases: Expert Consensus for Health Care Providers and Exercise Professionals
Authors: Campbell Kristin L. , Cormie Prue , Weller Sarah , Alibhai Shabbir M. H. , Bolam Kate A. , Campbell Anna , Cheville Andrea L. , Dalzell Mary-Ann , Hart Nicolas H. , Higano Celestia S. , Lane Kirstin , Mansfield Sami , McNeely Margaret L. , Newton Robert U. , Quist Morten , Rauw Jennifer , Rosenberger Friederike , Santa Mina Daniel , Schmitz Kathryn H. , Winters-Stone Kerri M. , Wiskemann Joachim , Goulart Jennifer
Published: January 2022

PURPOSE:

Exercise has been underutilized in people with advanced or incurable cancer despite the potential to improve physical function and reduce psychosocial morbidity, especially for people with bone metastases because of concerns over skeletal complications. The International Bone Metastases Exercise Working Group (IBMEWG) was formed to develop best practice recommendations for exercise programming for people with bone metastases on the basis of published research, clinical experience, and expert opinion.

METHODS:

The IBMEWG undertook sequential steps to inform the recommendations: (1) modified Delphi survey, (2) systematic review, (3) cross-sectional survey to physicians and nurse practitioners, (4) in-person meeting of IBMEWG to review evidence from steps 1-3 to develop draft recommendations, and (5) stakeholder engagement.

RESULTS:

Recommendations emerged from the contributing evidence and IBMEWG discussion for pre-exercise screening, exercise testing, exercise prescription, and monitoring of exercise response. Identification of individuals who are potentially at higher risk of exercise-related skeletal complication is a complex interplay of these factors: (1) lesion-related, (2) cancer and cancer treatment–related, and (3) the person-related. Exercise assessment and prescription requires consideration of the location and presentation of bone lesion(s) and should be delivered by qualified exercise professionals with oncology education and exercise prescription experience. Emphasis on postural alignment, controlled movement, and proper technique is essential.

CONCLUSION:

Ultimately, the perceived risk of skeletal complications should be weighed against potential health benefits on the basis of consultation between the person, health care team, and exercise professionals. These recommendations provide an initial framework to improve the integration of exercise programming into clinical care for people with bone metastases.
Real-World Data From a Molecular Tumor Board: Improved Outcomes in Breast and Gynecologic Cancers Patients With Precision Medicine
Authors: Charo Lindsey M. , Eskander Ramez N. , Sicklick Jason , Kim Ki Hwan , Lim Hyo Jeong , Okamura Ryosuke , Lee Suzanna , Subramanian Rupa , Schwab Richard , Shatsky Rebecca , Plaxe Steven , Kato Shumei , Kurzrock Razelle
Published: January 2022

PURPOSE

Next-generation sequencing is increasingly used in gynecologic and breast cancers. Multidisciplinary Molecular Tumor Board (MTB) may guide matched therapy; however, outcome data are limited. We evaluate the effect of the degree of matching of tumors to treatment as well as compliance to MTB recommendations on outcomes.

METHODS

Overall, 164 patients with consecutive gynecologic and breast cancers presented at MTB were assessed for clinicopathologic data, next-generation sequencing results, MTB recommendations, therapy received, and outcomes. Matching score (MS), defined as percentage of alterations targeted by treatment over total pathogenic alterations, and compliance to MTB recommendations were analyzed in context of oncologic outcomes.

RESULTS

Altogether, 113 women were evaluable for treatment after MTB; 54% received matched therapy. Patients with MS ≥ 40% had higher overall response rate (30.8% v 7.1%; P = .001), progression-free survival (PFS; hazard ratio [HR] 0.51; 95% CI, 0.31 to 0.85; P = .002), and a trend toward improved overall survival (HR 0.64; 95% CI, 0.34 to 1.25; P = .082) in univariate analysis. The PFS advantage remained significant in multivariate analysis (HR 0.5; 95% CI, 0.3 to 0.8; P = .006). Higher MTB recommendation compliance was significantly associated with improved median PFS (9.0 months for complete; 6.0 months for partial; 4.0 months for no compliance; P = .004) and overall survival (17.1 months complete; 17.8 months partial; 10.8 months none; P = .046). Completely MTB-compliant patients had higher MS ( P < .001). In multivariate analysis comparing all versus none MTB compliance, overall response (HR 9.5; 95% CI, 2.6 to 35.0; P = .001) and clinical benefit (HR 8.8; 95% CI, 2.4 to 33.2; P = .001) rates were significantly improved with higher compliance.

CONCLUSION

Compliance to MTB recommendations resulted in higher degrees of matched therapy and correlates with improved outcomes in patients with gynecologic and breast cancers.
Ultrasound-Guided Occipital Nerve Blocks to Reduce Tinnitus-Associated Otalgia: A Case Series
Authors: Skinner Colby , Kumar Sanjeev
Published: January 2022

Ear pain is mediated by cranial nerves V, IX, and X, as well as branches of C2 and C3, including the occipital nerve. Occipital neuralgia may play a role in the development or worsening of tinnitus and otalgia. The authors reviewed and report 33 cases of ultrasound-guided occipital nerve blocks in patients with tinnitus and otalgia, with postprocedure follow-up intervals of up to 2 years. We found that greater occipital nerve blocks may be a valuable treatment method for these patients.
Familial Undercurrents
Authors: Najmabadi Afsaneh
Published: January 2022

Not long after her father died, Afsaneh Najmabadi discovered that her father had a secret second family and that she had a sister she never knew about. In Familial Undercurrents, Najmabadi uncovers her family’s complex experiences of polygamous marriage to tell a larger story of the transformations of notions of love, marriage, and family life in mid-twentieth-century Iran. She traces how the idea of “marrying for love” and the desire for companionate, monogamous marriage acquired dominance in Tehran’s emerging urban middle class. Considering the role played in that process by late nineteenth- and early twentieth-century romance novels, reformist newspapers, plays, and other literature, Najmabadi outlines the rituals and objects---such as wedding outfits, letter writing, and family portraits---that came to characterize the ideal companionate marriage. She reveals how in the course of one generation men’s polygamy had evolved from an acceptable open practice to a taboo best kept secret. At the same time, she chronicles the urban transformations of Tehran and how its architecture and neighborhood social networks both influenced and became emblematic of the myriad forms of modern Iranian family life.
Listening in the Afterlife of Data
Authors: Cecchetto David
Published: January 2022

In Listening in the Afterlife of Data, David Cecchetto theorizes sound, communication, and data by analyzing them in the contexts of the practical workings of specific technologies, situations, and artworks. In a time he calls the afterlife of data—the cultural context in which data’s hegemony persists even in the absence of any belief in its validity—Cecchetto shows how data is repositioned as the latest in a long line of concepts that are at once constitutive of communication and suggestive of its limits. Cecchetto points to the failures and excesses of communication by focusing on the power of listening—whether through wearable technology, internet-based artwork, or the ways in which computers process sound—to pragmatically comprehend the representational excesses that data produces. Writing at a cultural moment in which data has never been more ubiquitous or less convincing, Cecchetto elucidates the paradoxes that are constitutive of computation and communication more broadly, demonstrating that data is never quite what it seems.
Discontinuous gas exchange in Madagascar hissing cockroaches is not a consequence of hysteresis around a fixed PCO2 threshold
Authors: Rowe Tormod T. C. , Gutbrod Martin S. , Matthews Philip G. D.
Published: January 2022

It has been hypothesised that insects display discontinuous gas-exchange cycles (DGCs) as a result of hysteresis in their ventilatory control, where CO2-sensitive respiratory chemoreceptors respond to changes in haemolymph PCO2 only after some delay. If correct, DGCs would be a manifestation of an unstable feedback loop between chemoreceptors and ventilation, causing PCO2 to oscillate around some fixed threshold value: PCO2 above this ventilatory threshold would stimulate excessive hyperventilation, driving PCO2 below the threshold and causing a subsequent apnoea. This hypothesis was tested by implanting micro-optodes into the haemocoel of Madagascar hissing cockroaches and measuring haemolymph PO2 and PCO2 simultaneously during continuous and discontinuous gas exchange. The mean haemolymph PCO2 of 1.9 kPa measured during continuous gas exchange was assumed to represent the threshold level stimulating ventilation, and this was compared with PCO2 levels recorded during DGCs elicited by decapitation. Cockroaches were also exposed to hypoxic (PO2 10 kPa) and hypercapnic (PCO2 2 kPa) gas mixtures to manipulate haemolymph PO2 and PCO2. Decapitated cockroaches maintained DGCs even when their haemolymph PCO2 was forced above or below the putative ∼2 kPa ventilation threshold, demonstrating that the characteristic oscillation between apnoea and gas exchange is not driven by a lag between changing haemolymph PCO2 and a PCO2 chemoreceptor with a fixed ventilatory threshold. However, it was observed that the gas exchange periods within the DGC were altered to enhance O2 uptake and CO2 release during hypoxia and hypercapnia exposure. This indicates that while respiratory chemoreceptors do modulate ventilatory activity in response to haemolymph gas levels, their role in initiating or terminating the gas exchange periods within the DGC remains unclear.
A heterothermic spectrum in hummingbirds
Authors: Shankar Anusha , Cisneros Isabelle N. H. , Thompson Sarah , Graham Catherine H. , Powers Donald R.
Published: January 2022

Many endotherms use torpor, saving energy by a controlled reduction of their body temperature and metabolic rate. Some species (e.g. arctic ground squirrels, hummingbirds) enter deep torpor, dropping their body temperature by 23–37°C, while others can only enter shallow torpor (e.g. pigeons, 3–10°C reduction). However, deep torpor in mammals can increase predation risk (unless animals are in burrows or caves), inhibit immune function and result in sleep deprivation, so even for species that can enter deep torpor, facultative shallow torpor might help balance energy savings with these potential costs. Deep torpor occurs in three avian orders, but the trade-offs of deep torpor in birds are unknown. Although the literature hints that some bird species (mousebirds and perhaps hummingbirds) can use both shallow and deep torpor, little empirical evidence of such an avian heterothermy spectrum within species exists. We infrared imaged three hummingbird species that are known to use deep torpor, under natural temperature and light cycles, to test whether they were also capable of shallow torpor. All three species used both deep and shallow torpor, often on the same night. Depending on the species, they used shallow torpor for 5–35% of the night. The presence of a heterothermic spectrum in these bird species indicates a capacity for fine-scale physiological and genetic regulation of avian torpid metabolism.
The resting frequency of echolocation signals changes with body temperature in the hipposiderid bat Hipposideros armiger
Authors: Schoeppler Diana , Denzinger Annette , Schnitzler Hans-Ulrich
Published: January 2022

Doppler shift (DS) compensating bats adjust in flight the second harmonic of the constant-frequency component (CF2) of their echolocation signals so that the frequency of the Doppler-shifted echoes returning from ahead is kept constant with high precision (0.1–0.2%) at the so-called reference frequency (fref). This feedback adjustment is mediated by an audio–vocal control system that correlates with a maximal activation of the foveal resonance area in the cochlea. Stationary bats adjust the average CF2 with similar precision at the resting frequency (frest), which is slightly below the fref. Over a range of time periods (from minutes up to years), variations of the coupled fref and frest have been observed, and were attributed to age, social influences and behavioural situations in rhinolophids and hipposiderids, and to body temperature effects and flight activity in Pteronotus parnellii. We assume that, for all DS-compensating bats, a change in body temperature has a strong effect on the activation state of the foveal resonance area in the cochlea, which leads to a concomitant change in emission frequency. We tested our hypothesis in a hipposiderid bat, Hipposideros armiger, and measured how the circadian variation of body temperature at activation phases affected frest. With a miniature temperature logger, we recorded the skin temperature on the back of the bats simultaneously with echolocation signals produced. During warm-up from torpor, strong temperature increases were accompanied by an increase in frest, of up to 1.44 kHz. We discuss the implications of our results for the organization and function of the audio–vocal control systems of all DS-compensating bats.
Board Committee Overlap and the Use of Earnings in CEO Compensation Contracts
Authors: Carter Mary Ellen , Lynch Luann J. , Martin Melissa A.
Published: January 2022

Using proxy statement data describing the terms of compensation contracts, we examine how overlapping membership between compensation and audit committees influences the use of earnings metrics in compensation. Although research predicts that such overlap could either increase or decrease the reliance on earnings, we find that firms with overlapping directors rely less on earnings-based performance measures in incentive contracts without altering the overall level of performance-contingent cash bonuses. In addition, we provide evidence that firms substitute earnings measures with measures less subject to earnings management. Our findings are robust to potential alternative explanations, extend to an implicit relation between earnings and compensation for a larger sample, and are not driven by the tendency toward an overlapping committee structure more broadly.

This paper was accepted by Suraj Srinivasan, accounting.
Michelin Is Coming to Town: Organizational Responses to Status Shocks
Authors: Favaron Saverio Dave , Di Stefano Giada , Durand Rodolphe
Published: January 2022

What happens in the aftermath of the introduction of a new status ranking? In this study, we exploit the unique empirical opportunity generated by the release of the first edition of the Michelin Guide for Washington, DC, in the fall of 2016. We build on prior work on rankings as insecurity-inducing devices by suggesting that newly awarded high-status actors modify their self-presentation attributes to fit with what they believe audiences expect from the elite. Our results show that, depending on their standing prior to Michelin’s entry, restaurants acted upon different attributes of their self-presentation. Restaurants with high prior standing emphasized attributes that channeled authenticity and exclusivity, which may imply that their Michelin designation triggered operational changes. Actors with low prior standing, on the other hand, acted on descriptive attributes that did not necessarily imply operational changes and could be easily manipulated to signal their belonging among the elite. We contribute to research on status and conformity by disentangling the sources and types of conformity behaviors that newly awarded high-status actors deploy.

This paper was accepted by Lamar Pierce, organizations.
Preregistration adult nursing programmes and promotion of a population health agenda: an investigation
Authors: Donaghy Pamela H , Greenhalgh Christine , Griffiths Jane , Verma Arpana
Published: January 2022

Promoting health and preventing ill health are key standards of proficiency for pre-registration nursing education in the UK. The knowledge and skills required to fulfil this role is dependent on students developing a clear understanding of population health during their educational experience. The websites of the 60 undergraduate adult nursing programmes in England that lead to registration were explored, to see how the population health agenda is presented in the information for future candidates. It was found that only 26% of universities promote a population health agenda in the general description of the adult nursing programme, emphasising clinical skills teaching and partnerships with hospital trusts for placement provision. To embrace the breadth of 21st century nursing practice, universities should be marketing nursing proficiencies and raising awareness of the wider context in which care is delivered during recruitment. This approach to branding has the potential to challenge stereotypes and widen participation.
The virtual ear, nose and throat follow-up clinic: a 10-year quality improvement project
Authors: Morris Simon , Agarwal Tanvi , Leopard Daniel , Costello Rhodri , Backhouse Steven
Published: January 2022

Background/Aims

Ear, nose and throat services have seen one of the greatest increases in service demand over the last 6 years. This study aimed to determine if a virtual clinic system could reduce the volume of patients who need to be seen in person in an ear, nose and throat outpatient clinic.

Methods

Clinical outcome data for one consultant's team in a single ear, nose and throat department between 2009–19 were analysed. Data were prospectively collected on all patients who used the virtual clinic in this 10-year period and the outcomes analysed.

Results

A total of 3071 patients entered the virtual clinic during the 10-year period. Of these, 61% were discharged from the clinic via virtual follow-up and 39% required an in-person review appointment. On average, 187 patients per year did not have to attend an in-person follow-up appointment, with estimated cost savings of £27 000 per year.

Conclusions

The virtual ear, nose and throat clinic service has clear benefits for patients and services, delivering healthcare without unnecessary in-person appointments through a shared, clinician–patient decision process.
Speech recognition for medical documentation: an analysis of time, cost efficiency and acceptance in a clinical setting
Authors: Zuchowski Matthias , Göller Aydan
Published: January 2022

Background/Aims

Medical documentation is an important and unavoidable part of a health professional's working day. However, the time required for medical documentation is often viewed negatively, particularly by clinicians with heavy workloads. Digital speech recognition has become more prevalent and is being used to optimise working time. This study evaluated the time and cost savings associated with speech recognition technology, and its potential for improving healthcare processes.

Methods

Clinicians were directly observed while completing medical documentation. A total of 313 samples were collected, of which 163 used speech recognition and 150 used typing methods. The time taken to complete the medical form, the error rate and error correction time were recorded. A survey was also completed by 31 clinicians to gauge their level of acceptance of speech recognition software for medical documentation. Two-sample t-tests and Mann–Whitney U tests were performed to determine statistical trends and significance.

Results

On average, medical documentation using speech recognition software took just 5.11 minutes to complete the form, compared to 8.9 minutes typing, representing significant time savings. The error rate was also found to be lower for speech recognition software. However, 55% of clinicians surveyed stated that they would prefer to type their notes rather than use speech recognition software and perceived the error rate of this software to be higher than typing.

Conclusions

The results showed that there are both temporal and financial advantages of speech recognition technology over text input for medical documentation. However, this technology had low levels of acceptance among staff, which could have implications for the uptake of this method.
The Space of Intimacy as The Most Important Islamic Cultural Value in Traditional Iranian Architecture
Authors:   Urban Planning Department, Imam Khomeni International University Buin Zahra Higher Education, Iran, Valibeigi Mojtaba , Maroofi Sakine ,   Urban Planning Department, Imam Khomeni International University Buin Zahra Higher Education, Iran, Danay Sara ,   Urban Planning Department, Imam Khomeni International University Buin Zahra Higher Education, Iran, Mokhtari Yegane ,   Urban Planning Department, Imam Khomeni International University Buin Zahra Higher Education, Iran
Published: January 2022

This study aims to carry out a critical reading of individual spaces of traditional Iranian houses. Through recourse to expert opinion, seven traditional houses in Iran have been chosen. A deductive content analysis is used to assess space syntaxes by way of three steps: preparation, organization, and the final report. In the preparation step, the individual and family territory in Iranian culture is defined. In the organization phase, territories are classified by reviewing plans, maps, and making visual observations. Finally, conclusions are reached on the situation of privacy and individuality in the houses. It is suggested that family privacy is the main function of traditional Iranian houses. Despite the fact that spaces could be used as personal and individual territories, in practice this is not so, and individualism and individual values have been forgotten. Individuality is not considered as valuable in the sense of one who needs his/her own territory; rather, this is determined in relation with other people. Keywords: Mahram Territories, Personal Spaces, Space Syntax, Territoriality, Traditional Iranian House
Continuous Fixed-Bed Column Studies of Textile Effluent Treatment using Multi-Walled Carbon Nanotubes Originated from Rosmarinus officinalis Oil
Authors: S. Valliammai  , K. Gopal  , R. Nithya  , L. Rama Priya  , D. Kavitha
Published: January 2022

A continuous adsorption study in a fixed-bed column was carried out using Multi-walled Carbon Nanotubes derived from Rosmarinus officinalis oil as an adsorbent for removing the textile dye Acid blue 40 from an aqueous solution. The adsorbent, MWNTs were prepared from Rosmarinus officinalis oil as a precursor to Fe/Mo catalyst supported on silica at 650 ºC under N2 atmosphere by spray pyrolysis process characterized by scanning electron microscopy, Transmission Electron microscopy, and Raman spectroscopy. The effects of adsorbent bed height (2–6 cm), initial ion concentration (20– 60 mg/L), and flow rate (10–30 mL/min) on the column performance were analyzed. The breakthrough curve was analyzed using the mathematical models of Thomas, Yoon-Nelson, and bed depth service time. The Thomas model at different conditions defined the behaviors of the breakthrough curves. The bed depth service time model showed good agreement with the experimental data. The high values of correlation coefficients (R2 0.9875) obtained indicate the validity of the bed depth service time model for the present column system.
Ochronotic Surprise during Total Knee Replacement! A Case Report
Authors: G Syam , John John Thayyil , Nair Dileep Sasidharan , Yadav Shikhar , Varghese Joice , T Jamsheed
Published: January 2022

Introduction:Alkaptonuria is a rare autosomal recessive metabolic disorder characterized by accumulation of homogentisic acid (HGA) due to an inherited deficiency of the enzyme HGA oxidase. Unlike rheumatoid arthritis which affects the small joints of the hands and feet, ochronotic arthropathy predominantly involves the large weight-bearing joints such as hips, knees, and spine. The knee is the most common joint to be affected. Ochronotic arthropathy is usually managed conservatively, but for severely affected hip and knee joints, replacement is considered.

Case Report:This report describes a case of 57-year-old male who presented with bilateral knee osteoarthritis who was incidentally diagnosed with ochronosis intraoperatively during total knee arthroplasty, its challenges faced and post-operative functional outcome after 18 months follow-up.

Conclusion:This case report highlights the need for high index of suspicion for preoperative diagnosis of ochronotic arthropathy. Difficult spinal anesthesia should be anticipated. Friable and stiff tendon due to ochronotic involvement can put the extensor tendon at risk of rupture during retraction of patella intraoperatively. Post-operative active quadriceps rehabilitation should be done with caution due to friable tendon.

Keywords:Alkaptonuria, ochronosis, ochronotic arthropathy, autosomal recessive, total knee arthroplasty.
In vivo Histological Examination of the Graft Site 3 Years after Open-wedge High Tibial Osteotomy with Nanohydroxyapatite Augmentation
Authors: Princi Giorgio , Rossini Marco , Marzilli Fabio , Niccolo Riccardo Di , Conteduca Fabio , Ferretti Andrea
Published: January 2022

Introduction:The open-wedge high tibial osteotomy (OWHTO) is a common technique for the treatment of medial compartmental osteoarthritis of the knee. There are many options to fill the osteotomy site gap. The autologous graft donor site morbidity can be avoided using heterologous bone grafts which represent a valid alternative.

Case Presentation:This case report is about a 52-year-old male with knee osteoarthritis and varus deformity. Due to stiffness, swelling, and painful limitation during daily life activities, the patient underwent OWHTO. The osteotomy gap was filled with an equine cancellous bone wedge and nanohydroxyapatite (NHA) bone paste augmentation. After 3 years, the OWTHO was converted to total knee arthroplasty and a bone biopsy of the previous graft site was performed. The histological examination presented non-viable bone areas surrounded by viable bone without inflammatory cells, suggesting the presence of residual non-viable bone from the bone substitute graft.

Conclusion:The in vivo histology of the graft site after 3 years has shown that heterologous bone is a safe and valid choice as a scaffold for bone regeneration. Augmentation with NHA bone paste achieved good osteoinduction without an inflammatory reaction and good integration of the bone substitute insert.

Keywords: High tibial osteotomy, histology, heterograft.
Acromioclavicular Joint Pseudo-dislocations with Lateral end Clavicle Fracture: A Rare Injury and Proposed Technique of Fixation
Authors: Al-Yaseen Mustafa , Seyed-Safi Parisah , Makki Daoud , Dubey Vivek
Published: January 2022

Introduction: Lateral end clavicle fractures are rare injuries in pediatric and adolescent population. Most of these injuries can be managed conservatively. However, in patients with acromioclavicular joint (ACJ) “pseudo-dislocations” associated with significant clinical deformity, some patients will benefit from operative intervention.

Case Report:Our reported case is a young adolescent with a Type IV Dameron and Rockwood distal clavicle fracture and ACJ pseudo-dislocation, who underwent surgical fixation for this injury. We propose a novel technique of fixation with a suture anchor and endo button with temporary K wire stabilization. These are rare injuries and there are no standardized techniques for reconstruction and fixation. Stabilization with a suture anchor can provide a minimally invasive method of fixation for such injuries without the traditional plating and can lead to excellent final outcomes.

Conclusion:ACJ pseudo-dislocations are rare injuries. There is limited evidence in guiding the management of such injuries. Our proposed technique of fixation with suture anchor, endo button and temporary stabilisation with K-wire can provide promising results.

Keywords:Clavicle fracture, paediatrics, suture anchors, acromioclavicular joint, trauma.
An Uncommon Complication of Arteriovenous Fistula Following Intramedullary Nail Distal Locking – A Case Report
Authors: Levy Yahav , Feldman Guy , Weil Yoram A , Jammal Mahmoud
Published: January 2022

Introduction:An arterial pseudo aneurysm formation is an unusual complication following intramedullary nail distal locking screw insertion. During such surgical procedure, arterial laceration might damage the wall, allowing blood leakage into the soft- tissue surrounding. Only few records are available regarding such injuries.

Case Report: A 19-year-old male diagnosed with femoral shaft fracture after a trauma event, was treated using Antegrade Long Intra-Medullary Nail with distal locking screw. Following post-operative serial blood count indicating a consistent decrease in his Haemoglobin levels, a Computed Tomography angiogram was performed and showed an arteriovenous fistula of the lateral superior geniculate artery. The artery was coiled, and haemoglobin levels were stabilized again.

Conclusion: A distal interlocking screw should be carefully placed, including blunt dissection before the drilling and screw placement. In addition, blood counts were proved essential in routine.

Keywords: Arteriovenous fistula, intramedullary nail distal locking, antegrade long intra-medullary nail.
Monteggia Variant with Salter-Harris Fracture of the Radial Head: Case Report and Litergature Review
Authors: Sahemey Rajpreet , Nikolaides Anastasios P
Published: January 2022

Introduction:The Monteggia fracture is a fracture to the proximal third of ulna associated with a radial head dislocation. Although this is well described and classified in adults, it is uncommon in children. Identifying growth plate trauma and subsequent surgical management are of critical importance. This report identifies a unique variant of Monteggia fracture with a Salter-Harris Type I injury of the radial head instead of a dislocation, and how it was successfully stabilised with a closed reduction.

Case Rport: We present a case of a nine 9 year-old female admitted to our unit with a deformed upper extremity following a fall from height. This was a closed and isolated injury without neurovascular compromise. Radiographs revealed a displaced fracture to the proximal ulna shaft. Unlike a true Monteggia, the radial fracture went through the proximal physis with anterior divergence of the distal fragment. The radiocapitellar joint remained congruent. The ulna fracture was stabilized with open reduction and plate osteosynthesis whilst the radial injury underwent closed reduction and intramedullary pinning with excellent outcomes and maintenance of full range of motion.

Conclusion: This case highlights a new variant and successful outcome following a closed reduction intramedullary fixation technique in this emergent pattern of injury. We highlight the need for a classification of these fractures in children.

Keywords: Case report, Monteggia, growth plate, pediatric, fracture, trauma, variant.