bluuebunny/crossref_metadata_2025 huggingface dataset:
Optogenetically engineered Ca2+ oscillation-mediated DRP1 activation promotes mitochondrial fission and cell death
Authors: Lai Yi-Shyun , Chang Cheng-Chi , Chen Yong-Yi , Nguyen Thi My Hang , Xu Jixuan , Chen Ying-Chi , Chang Yu-Fen , Wang Chia-Yih , Chen Pai-Sheng , Lin Shih-Chieh , Peng I-Chen , Tsai Shaw-Jenq , Chiu Wen-Tai
Published: May 2023

Mitochondrial dynamics regulate the quality and morphology of mitochondria. Calcium (Ca2+) plays an important role in regulating mitochondrial function. Here, we investigated the effects of optogenetically engineered Ca2+ signaling on mitochondrial dynamics. More specifically, customized illumination conditions could trigger unique Ca2+ oscillation waves to trigger specific signaling pathways. In this study, we found that modulating Ca2+ oscillations by increasing the light frequency, intensity and exposure time could drive mitochondria toward the fission state, mitochondrial dysfunction, autophagy and cell death. Moreover, illumination triggered phosphorylation at the Ser616 residue but not the Ser637 residue of the mitochondrial fission protein, dynamin-related protein 1 (DRP1, encoded by DNM1L), via the activation of Ca2+-dependent kinases CaMKII, ERK and CDK1. However, optogenetically engineered Ca2+ signaling did not activate calcineurin phosphatase to dephosphorylate DRP1 at Ser637. In addition, light illumination had no effect on the expression levels of the mitochondrial fusion proteins mitofusin 1 (MFN1) and 2 (MFN2). Overall, this study provides an effective and innovative approach to altering Ca2+ signaling for controlling mitochondrial fission with a more precise resolution than pharmacological approaches in the temporal dimension.
Como se formam comunidades de consumo no TikTok
Authors: Do Nascimento Thaysa Costa
Published: May 2023

Analisar como comunidades de consumo são criadas e promulgadas na plataforma de rede social TikTok.
Study directions and development of cognitive theory of depression
Authors: Golonka Krystyna , Piątek Elżbieta , Stach Ryszard
Published: May 2023

Poznawczy model depresji Aarona T. Becka stał się podstawą analizy czynników poznawczych jako istotnych korelatów i predyktorów depresji. Psychologiczne mechanizmy depresji odnoszące się do depresyjnej triady poznawczej, specyfiki schematów poznawczych oraz błędów w przetwarzaniu poznawczym określiły kierunki kolejnych badań nad depresją.
Przedstawiona analiza wybranych badań potwierdza i poszerza założenia Becka o roli czynników poznawczych w rozwoju i podtrzymywaniu objawów depresyjnych. Analiza badań psychologicznych, neuroobrazowych i biochemicznych określa szerszą perspektywę rozumienia zarówno etiologii, jak i mechanizmów podtrzymujących objawy depresji. Rozwój badań neuroobrazowych poszerzył wiedzę o mechanizmach mózgowych depresji – przedstawione badania łączą teoretyczne konstrukty poznawczej koncepcji depresji z charakterystyką aktywności struktur mózgowych i ich funkcjonalnych połączeń. Dla praktyki klinicznej szczególnie istotne wydają się następujące wnioski: 1) upośledzenie funkcji hamowania poznawczego w depresji ogranicza kontrolę negatywnych myśli automatycznych – istotne znaczenie ma wzmacnianie pamięci operacyjnej; 2) odmienne mózgowe mechanizmy przetwarzania nagród i kar u osób cierpiących na depresję i u osób zdrowych wyjaśniają kształtowanie samooceny – wiedza ta może być ważnym elementem psychoedukacji w pracy terapeutycznej; 3) badania neuroobrazowe wskazują na neuronalne korelaty zniekształceń poznawczych obserwowanych w depresji – dla dalszych badań nad depresją szczególnie istotne byłoby monitorowanie zmian aktywności mózgowej w przebiegu jej leczenia.
Advancements in Radiology and Diagnostic Imaging
Authors: Łoginoff Jan , Augustynowicz Kinga , Świąder Kinga , Ostaszewska Sandra , Morawski Przemysław , Pactwa Filip , Popińska Zuzanna
Published: May 2023

Radiology and diagnostic imaging have undergone remarkable advancements in recent years, shaping the future of healthcare and improving patient outcomes. This review article provides an extensive overview of the developments and opportunities in various aspects of radiology, including CT, MRI, ultrasound, digital radiology, teleradiology, 3D printing, radiomics, radiogenomics, and nuclear radiology. It highlights the integration of artificial intelligence and machine learning in radiology, the emergence of theranostics, and the exploration of the human microbiome. The article also delves into advanced imaging techniques for cardiovascular diseases, hybrid imaging modalities in oncology, and optical imaging. The summary emphasizes the importance of continued innovation and development in radiology and diagnostic imaging to enhance patient care and global health outcomes.
Associação entre atividade física e saúde mental durante a pandemia COVID-19: um estudo transversal
Authors: Brito Ana Tereza de Sousa , Pereira Deborah Santana Pereira , Cirilo-Sousa Maria do Socorro , Esmeraldo Anthony Pedro Igor Sales Rolim , Loiola Matheus Luna , Victor Narcélio Pinheiro
Published: May 2023

O objetivo do presente estudo foi investigar a associação entre níveis de atividade física e sintomas de ansiedade e depressão. Foi elaborado um questionário online no Google Forms® com questões objetivas e abertas para avaliar as questões relacionadas à prática de atividade física e saúde mental durante o período da pandemia da COVID-19. O formulário incluiu perguntas relacionadas a aspectos sociodemográficos, nível de atividade física (IPAQ –versão curta) e análise da saúde mental dos participantes com as escalas de Ansiedade e Depressão de Beck. A associação entre atividade física e saúde mental foi estimada por meio de modelos de regressão. Cento e noventa e três pessoas responderam ao questionário (59% do sexo feminino). As mulheres apresentaram maiores níveis de ansiedade e depressão quando comparadas aos homens (p < 0,001 para todos os domínios). O risco de ter sintomas graves de ansiedade e depressivos aumentou respectivamente (OR = 4,20; IC95%: 1,25 - 14,11), e (OR = 3,16; IC95%: 1,12 - 8,91) nos participantes classificados com nível baixo de atividade física quando comparados aos quem mantêm o nível mais alto. Os homens têm menos chances de terem sintomas de ansiedade (OR= 0,23; IC95%: 0,10 - 0,55 p < 0,001) e depressão (OR = 0,33 IC95%: 0,12 - 0,88). Em suma, pode-se concluir que, durante a pandemia de COVID-19, os participantes que obtiveram alto nível de atividade física têm menos chances de apresentar sintomas graves de ansiedade e moderado de depressão.
Data-Driven Distributionally Robust Optimization over Time
Authors: Aigner Kevin-Martin , Bärmann Andreas , Braun Kristin , Liers Frauke , Pokutta Sebastian , Schneider Oskar , Sharma Kartikey , Tschuppik Sebastian
Published: May 2023

Stochastic optimization (SO) is a classical approach for optimization under uncertainty that typically requires knowledge about the probability distribution of uncertain parameters. Because the latter is often unknown, distributionally robust optimization (DRO) provides a strong alternative that determines the best guaranteed solution over a set of distributions (ambiguity set). In this work, we present an approach for DRO over time that uses online learning and scenario observations arriving as a data stream to learn more about the uncertainty. Our robust solutions adapt over time and reduce the cost of protection with shrinking ambiguity. For various kinds of ambiguity sets, the robust solutions converge to the SO solution. Our algorithm achieves the optimization and learning goals without solving the DRO problem exactly at any step. We also provide a regret bound for the quality of the online strategy that converges at a rate of [Formula: see text], where T is the number of iterations. Furthermore, we illustrate the effectiveness of our procedure by numerical experiments on mixed-integer optimization instances from popular benchmark libraries and give practical examples stemming from telecommunications and routing. Our algorithm is able to solve the DRO over time problem significantly faster than standard reformulations.

Funding: This work was supported by Deutsche Forschungsgemeinschaft (DFG): Projects B06 and B10 in CRC TRR 154 and Project-ID 416229255 - SFB 1411 and Federal Ministry for Economic Affairs and Energy, Germany [Grant 03EI1036A].

Supplemental Material: The e-companion is available at https://doi.org/10.1287/ijoo.2023.0091 .
Acquisitions and Corporate Purpose
Authors: Gartenberg Claudine , Yiu Shun
Published: May 2023

Purpose is undergoing a resurgence of interest across research and practice. Yet, we know little about how it relates to strategy and specifically, how strategic actions reinforce or undermine purpose in organizations. This study explores this question in the context of acquisitions. We examine 831 transactions using data from approximately 1.7 million employees to construct our measure of purpose. We find that, on average, employees’ sense of purpose drops after acquisitions. This drop is particularly pronounced among firms that undertake unique acquisitions: those involving unusual industry combinations. This relationship suggests a possible tension between strategic and motivational consequences of boundary changes. Firms may benefit strategically from these changes, particularly those that enable expansion into unique areas. These same actions, however, may also erode the purpose of the organization, with consequences for downstream performance.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/stsc.2023.0193 .
An Overview of Breeding Objectives to Improve the Economically Important Traits in Oat
Authors: J. Hilli Harshavardan , Kapoor Rahul
Published: May 2023

The history of the modern oat may be traced to its intergeneric contamination of wheat and barley in southwest Asia, particularly in Mesopotamia and due to its use in only forage crop rather than a staple food in most of the countries it’s been neglected. There are just a few economically cultivated species of this self-pollinated crop, including A. sativa, A. nuda, and A. byzantina. After rice, wheat, maize, sorghum, and barley, oat production comes in at number six and in terms of oat production (FAO 2019). The present review was undertaken in order to address the present scenario of oats utilization and its consideration in research. The work majorly focussed in present are β glucan (due to its nutritional status) and disease resistance (majorly powdery mildew, pyrenophora leaf spot and crown rust) throughout the world but some drawbacks is that oats is usually neglected because of its limited use as forage value and also of its hexaploid nature. The different breeding methods employed till date for crop improvement are described in the chapter viz, traditional methods, diversity studies, mapping strategies, Marker aided breeding Association mapping, Genomic assisted breeding etc. Some of the qtls mapped by various researchers for different traits is also been listed in this article. Apart from these studies, the novel techniques which are still lacking in oats has much scope now to get it utilized through various improvement programmes like in other cereal crops.
Liquid Culture System: An Efficient Approach for Sustainable Micropropagation
Authors: Nirmal Dhaval , Teraiya Sagar , Joshi Preetam
Published: May 2023

Micropropagation of important forestry, horticultural and medicinal plants have made revolutionary changes in terms of research and commercialization. However, there are a variety of factors which influence the scaling-up and commercialization aspects, which decide whether mass propagation will be effective and lucrative. Low rates of shoot multiplication, increased costs of media components, loss of cultures due to contamination, and difficulties with hardening and acclimation are the key obstacles to scaling up micropropagation technology. These restrictions have forced a large number of in vitro technologies developed for a range of plant species to be used only under research laboratories settings. To apply tissue culture technology to large-scale propagation, it is required to develop techniques that are relatively simple to adopt, have high multiplication rate with high levels of reproducibility, and exhibit higher survival of plantlets when transferred to ex vitro conditions. Efficient techniques include utilization of liquid culture systems and replacement of agar with other gelling agents. These techniques allow development of micropropagules that not only function better in post-vitro soil conditions and are comparatively less expensive, but will also help develop a workable micropropagation technique that can be applied to the mass production of desirable plant species. The current review describes liquid culture system as an efficient approach to produce large number of plants at low production cost.
Growth effects of Pseudomonas, a Plant Growth- Promoting Rhizobacteria on Spinach (Spinacia oleracea L.) - A Review
Authors: P Purnima , Singh Pooja
Published: May 2023

Plant growth- promoting rhizobacteria (PGPR), is a consortium of such bacteria which colonizes the roots of plants and show beneficial effects on growth and yield of plant. Pseudomonas is found to be most potent PGPR, occurring globally and having positive effect on productivity of plant. This review unravels several species of Pseudomonas which enhance growth and yield of spinach and can be used as biofertilizer. Certain species of Pseudomonas have been discovered which in absence of any chemical fertilizer can increase productivity of spinach alone. Investigation of such PGPR in case of spinach is quiet important as spinach cultivation make use of large amount of chemical fertilizers which are deleterious to health of crop, environment and human beings altogether. This review also introduces certain methods of inoculation of Pseudomonas sp. which encourages colonization around root or seeds of spinach, hence upgrading its association with spinach and yield in short. Thus, this review draws attention to explore more about Pseudomonas in case of green leafy spinach, inorder to gain large scale productivity and field application of it, which promotes organic farming and goodness of well-being.
Morpho-Physiological Phenotyping of Fifteen Farmers Rice Varieties and Assessment of Grain Quality
Authors: Sarker Aparna , Roy Subhas Chandra
Published: May 2023

The present study high-lighted on the yet-explored extensive analyses
of eating and cooking quality parameters in fifteen indigenous rice varieties. As rice is a vital staple crop globally that can feed one-third world’s population solely, it is an imperious task to develop research for enhancement of its nutritional as well as eating and cooking quality (ECQ). The exploitation
of identified nutrient-enriched rice germplasm for breeding application
is the easiest way to get better quality rice. Satabdi IET-4786 (SAT) appeared to be very demanding by virtue of having sufficient level of amylose which
is considered as key determinant of grain quality. The importance of Sabita (SAB), with regards to higher content of amylose and maltose with higher α-amylase activity and of Dudheshwar (DUD) with respect to protein and total free amino acid content in rice grain was also significant. Here we analyzed fifteen different local rice germplasms including aromatic and some high yielding cultivars to identify some qualitative as well as some quantitative traits related to nutrition and consumers’ acceptance.
The knowledge gained from this study will largely provide a path direction for the making a proper decision of considering germplasms for large-scale cultivation and dietary consumption.
Fresnel-type solid immersion lens for efficient light collection from quantum defects in diamond
Authors: Park SungJoon , Koh Young-Seo , Kang Dongyeon Daniel , Kim Gyeonghun , Kim Kiho , Kim Dohun
Published: May 2023

Quantum defects in diamonds have been studied as a promising resource for quantum science. The subtractive fabrication process for improving photon collection efficiency often require excessive milling time that can adversely affect the fabrication accuracy. We designed and fabricated a Fresnel-type solid immersion lens using the focused ion beam. For a 5.8 µm-deep Nitrogen-vacancy (NV-) center, the milling time was highly reduced (1/3 compared to a hemispherical structure), while retaining high photon collection efficiency (> 2.24 compared to a flat surface). In numerical simulation, this benefit of the proposed structure is expected for a wide range of milling depths.
Decoupling bulk and surface characteristics with a bare tilted fiber Bragg grating
Authors: Li Zhihong , Wang Fei , Wang Yanan , Jin Xinxin , Duan Yanmin , Zhu Haiyong
Published: May 2023

The tilted fiber Bragg grating (TFBG) with dense comb-like resonances offers a promising fiber-optic sensing platform but could suffer from cross sensitivity dependent on bulk and surface environment. In this work, the decoupling of bulk and surface characteristics (indicated by bulk refractive index (RI) and surface-localized binding film) from each other is attained theoretically with a bare TFBG sensor. This is realized with the proposed decoupling approach based on differential spectral responses of cut-off mode resonance and mode dispersion represented as wavelength interval between P- and S-polarized resonances of the TFBG to the bulk RI and surface film thickness. The results demonstrate that with this method the sensing performance for decoupling bulk RI and surface film thickness is comparative to the cases in which either the bulk or surface environment of the TFBG sensor changes, with the bulk and surface sensitivities over 540 nm/RIU and 12 pm/nm, respectively.
Shape and polarization distribution of non-circular conical diffraction beams from conjugate cascades
Authors: Iqbal Muhammad Waqar , Marsal Nicolas , Montemezzani Germano
Published: May 2023

Peculiar non-circularly shaped vector type beams can be obtained naturally by the conical diffraction phenomenon if specific manipulations in wavevector space are performed between optically biaxial crystals arranged in a cascade. We analyze in detail this situation by focusing on the general shapes and the polarization distribution. Both are shown to be correlated to the values of structure parameters introduced in this work. These control parameters depend on the conical diffraction cone aperture angle, on the crystal lengths, and on the magnification values due to x- and y-oriented cylindrical lenses placed between the crystals and coupling common conjugate planes. The local polarization is found to be always linear with the exception of regions where structures composing the pattern intersect or overlap, where elliptical or circular polarization can occur. The way in which the obtained patterns depend on the orientation of individual crystal samples around the common optical axis and on an eventual polarization filtering at various stages of the cascade is discussed as well. Theoretical and experimental findings agree well, as verified for the case of a cascade of two crystals.
High-performance transient SBS-based microwave measurement using high-chirp-rate modulation and advanced algorithms
Authors: Wang Henan , Dong Yongkang
Published: May 2023

The transient stimulated Brillouin scattering (SBS) effect, enabled by optical chirp chain (OCC) technology, has already been proposed and demonstrated for microwave frequency identification with high temporal resolution. Through increasing the OCC chirp rate, the instantaneous bandwidth can be effectively extended without loss of the temporal resolution. However, the higher chirp rate results in more asymmetric transient Brillouin spectra, which worsens the demodulation accuracy when using the traditional fitting method. In this Letter, advanced algorithms, including image processing and artificial neural network, are employed to improve the measurement accuracy and demodulation efficiency. A microwave frequency measurement scheme is implemented with 4 GHz instantaneous bandwidth and 100 ns temporal resolution. Through the proposed algorithms, the demodulation accuracy of transient Brillouin spectra under 50 MHz/ns high chirp rate is improved from 9.85 MHz to 1.17 MHz. Moreover, owing to the matrix computations of the proposed algorithm, the time consumption is reduced by two orders of magnitude compared with the fitting method. The proposed method allows a high-performance OCC transient SBS-based microwave measurement, which provides new possibilities to realize real-time microwave tracking for diverse application fields.
Electroacupuncture treatment of primary dysmenorrhea: A randomized, participant-blinded, sham-controlled clinical trial protocol
Authors: Xue Xiao , Liu Xin , Pan Sian , Li Juan , Wang Shaohua , Yuan Hanyu , Liu Yu , Yue Zenghui
Published: May 2023

Background

Primary dysmenorrhea in women is a common and serious public health problem with psychological and physical effects. Painkillers have adverse effects, such as tolerance, addiction, irritation of the digestive tract, and liver and kidney damage. Electroacupuncture has been used as alternative therapy, although with no (non-anecdotal) evidence of effectiveness.

Objective

This study aims to provide evidence for the feasibility and efficacy of electroacupuncture in the treatment of primary dysmenorrhea. Moreover, by observing changes in serum and urine metabolites, we will evaluate the putative mechanisms mediating electroacupuncture effects in primary dysmenorrhea.

Methods

This multicenter, randomized, participant-blinded, sham-controlled clinical trial including 336 women with primary dysmenorrhea is being conducted at three hospital centers in China and consists of a 12-week treatment and a 3-month follow-up. Women will undergo electroacupuncture (n = 168) or sham acupuncture (n = 168), beginning 7 days before their menstruation, once per day, until menstruation. Each menstrual cycle equals one course of treatment, and we will evaluate a total of three courses of treatment. The primary outcome of interest is the change in visual analogue scale scores before and after treatment. The secondary outcomes include changes in the numeric rating scale, Cox Menstrual Symptom Scale, traditional Chinese medicine symptoms, the Self-Rating Anxiety Scale, Self-Rating Depression Scale, and 36-Item Short Form questionnaire scores, and a safety evaluation. Moreover, we will preliminarily investigate the metabolomics mechanism as a potential mediator of the association between electroacupuncture and primary dysmenorrhea symptomology.

Discussion

We aim to find a suitable non-medicinal alternative for primary dysmenorrhea treatment to reduce reliance on non-steroidal anti-inflammatory drugs.

Trial registration

Chinese Clinical Trial Registry: ChiCTR2100054234; http://www.chictr.org.cn/.
Beta1-receptor blockade attenuates atherosclerosis progression following traumatic brain injury in apolipoprotein E deficient mice
Authors: Wang Jintao , Venugopal Jessica , Silaghi Paul , Su Enming J. , Guo Chiao , Lawrence Daniel A. , Eitzman Daniel T.
Published: May 2023

Traumatic brain injury (TBI) is associated with cardiovascular mortality in humans. Enhanced sympathetic activity following TBI may contribute to accelerated atherosclerosis. The effect of beta1-adrenergic receptor blockade on atherosclerosis progression induced by TBI was studied in apolipoprotein E deficient mice. Mice were treated with metoprolol or vehicle following TBI or sham operation. Mice treated with metoprolol experienced a reduced heart rate with no difference in blood pressure. Six weeks following TBI, mice were sacrificed for analysis of atherosclerosis. Total surface area and lesion thickness, analyzed at the level of the aortic valve, was found to be increased in mice receiving TBI with vehicle treatment but this effect was ameliorated in TBI mice receiving metoprolol. No effect of metoprolol on atherosclerosis was observed in mice receiving only sham operation. In conclusion, accelerated atherosclerosis following TBI is reduced with beta-adrenergic receptor antagonism. Beta blockers may be useful to reduce vascular risk associated with TBI.
Effective PID controller design using a novel hybrid algorithm for high order systems
Authors: Izci Davut , Ekinci Serdar , Hussien Abdelazim G.
Published: May 2023

This paper discusses the merging of two optimization algorithms, atom search optimization and particle swarm optimization, to create a hybrid algorithm called hybrid atom search particle swarm optimization (h-ASPSO). Atom search optimization is an algorithm inspired by the movement of atoms in nature, which employs interaction forces and neighbor interaction to guide each atom in the population. On the other hand, particle swarm optimization is a swarm intelligence algorithm that uses a population of particles to search for the optimal solution through a social learning process. The proposed algorithm aims to reach exploration-exploitation balance to improve search efficiency. The efficacy of h-ASPSO has been demonstrated in improving the time-domain performance of two high-order real-world engineering problems: the design of a proportional-integral-derivative controller for an automatic voltage regulator and a doubly fed induction generator-based wind turbine systems. The results show that h-ASPSO outperformed the original atom search optimization in terms of convergence speed and quality of solution and can provide more promising results for different high-order engineering systems without significantly increasing the computational cost. The promise of the proposed method is further demonstrated using other available competitive methods that are utilized for the automatic voltage regulator and a doubly fed induction generator-based wind turbine systems.
KUASA KIAI DALAM PEMAKNAAN POLITIK PARTAI KEBANGKITAN BANGSA DI DAERAH ISTIMEWA YOGYAKARTA
Authors: Azizah Tsaniyatul
Published: May 2023

Hasil dari penelitian yang telah penyusun lakukan menunjukkan bahwa pertama di DIY kiai tetap memiliki kuasa dalam PKB. Ini dikarenakan kultur PKB DIY masih sama dengan NU pada umumnya. Namun, tidak semua kiai memiliki kekuasaan untuk memutuskan/ memberi kebijakan partai. Kedua, Kekuasaan kiai dalam PKB di DIY ini simetris (seimbang) tidak terlihat adanya superordinasi dan subordinasi. Sehingga kekuasaan kiai di PKB ini tidak mutlak. Setiap kebjakan selalu ada kordinasi yang baik antara Dewan Syura dan Dewan Tanfidz. Ketiga, peran kiai dalam PKBDIY ada tiga bentuk. Sebagai aktor, pendukung dan sebagai partisipan. Sebagai aktor, kiai langsung terjun ke dalam garis perjuangan PKB, misalnya dalam kelahiran PKB DIY. Selanjutnya sebagai pendukung maksudnya pada peran ini, kiai mendukung terhadap PKB, namun tidak berada di garis depan dalam memperjuangkan PKB DIY. Selanjutnya yakni sebagai partisipan, adalah kiai memberikan restu terhadap calon tertentu, dan tidak terlibat dalam aksi dukungan, atau menjadi tim sukses. Jadi tidak semua kiai fokus pada PKB DIY, kebanyakan kiai tersebut lebihmemilih fokus pada pesantren yang diasuhnya.
REMISI BAGI TERORIS PERSPEKTIF HUKUM PIDANA ISLAM
Authors: Dani Ahmad
Published: May 2023

Menurut hukum pidana Islam, pemidanaan dimaksudkan untuk mendatangkan kemaslahatan umat dan mencegah kemudaratan. Adanya pengurangan hukuman bagi narapidana terorisme sama saja memberikan kesempatan untuk tumbuhnya kejahatan. Dan juga dapat mecinderai rasa keadilan masyarakat sebagai korban dari tindak pidana terorisme yang menuntut untuk ditindak seberat-seberatnya setimpal dengan perbuatan. Penghapusan pengurangan hukuman bagi narapidana terorisme merupakan salah satuh dari implementasi saddaż-żarī‘ah agar pelaku tindak pidana terorisme tidak melakukan aksi terorisme lagi (residivis).
Beneficios de la gestión del capital humano empresarial y global
Authors: Eraso Espinosa Yisleidy Maritza , Salazar Muñoz Luisa Fernanda
Published: May 2023

Este artículo de revisión tiene como objetivo conocer los beneficios empresa-riales y globales que trae la gestión en capital humano con una recopilación de autores y fuentes que permiten establecer las diferentes utilidades para su aná-lisis y comprender su importancia. Para ello, se empleó como metodología una revisión documental en la que se consideraron como criterios de inclusión que fueran documentos provenientes de repositorios de tesis de pregrado, maestría y doctorado, artículos en inglés y español, artículos de estudios científicos, artí-culos de revisión y artículos que contengan temas de capital humano o la gestión de este. Como resultados, se relaciona que, para la obtención de beneficios tanto empresariales como globales en relación con la gestión del capital humano, se debe considerar el incentivo monetariamente, es decir, que el salario debe sa-tisfacer las necesidades, de modo que este sea justo, con lo cual se estimula la economía nacional por efectos de incremento en el consumo, siempre y cuando lo demás permanezca constante. Se concluyó que existe una relación directa en-tre los países industrializados o altamente desarrollados y el índice de capital humano (ICH), debido a las condiciones que permiten esta relación, es decir, los esfuerzos tanto institucionales de carácter estatal como los privados, a causa de la evidencia que se tiene en cuanto a la inversión en educación, capacitación y sa-lud. No obstante, existen otros factores que pueden ser limitantes, por ejemplo, la devaluación de la moneda que se traduciría en una pérdida del poder adquisi-tivo y en una disminución de los niveles de inversión.
Evaluation of a teleoperated vehicle for educational purposes
Authors: Hernández-Eskenazi Abel , Herrera-Martínez Josué Daniel , García-Mesa Raydel
Published: May 2023

The use of robotics vehicles in the education of children and teenagers constitutes a modern tendency of great interest in Cuba, due to the quantity of knowledge that provides and the variety of disciplines that it integrates. The present work has as objective to evaluate the use of a teleoperated and robotic vehicle based on Arduino, in the education of children and adolescents from Cuba. It includes the study of the state of the art about educational robotics in the world and in Cuba, who allows to define the main educational activities permitted by robots and the parameters to evaluate in the vehicle of analysis. Afterwards, it carries out a description of the technical specifications of the device, which influences in the benefits obtained by the use of the vehicle. Finally, it carries out the evaluation taking into account the defined parameters in the study of the state of the art. It obtains as conclusions that the use of the vehicle with educational purposes would be very fruitful, in spite of minimum limitations that do not put directly in risk the quality of educational activities.
Georg Brandes as an Actor Narrating a Story about Poland
Authors: Schab Sylwia Izabela
Published: May 2023

The aim of the article is to investigate Brandes’s impact on the Poles’ self-image and to explain how he became an actor in an internal Polish network of relationships. Three aspects have been analysed with regard to this aim: the reception of Brandes in Poland, reception of Scandinavian literature in Poland as an outcome of the Danish critic’s visits and his reception, and the contemporary virtual guide to Poland “Where is Poland?”, where he is used to provide guidance on how to understand Poland. Actor-Network-Theory provides the inspiration for how to present the intertwined relations of Polish and Danish literary cultures, with changing actants and with Brandes being the key actor.
Knut Hamsuns Pan og Joseph Conrads Heart of Darkness
Authors: Humpál Martin
Published: May 2023

The article examines similarities between ”Glahns død. Et papir fra 1861”, i.e., the second part of Knut Hamsun’s novel Pan (1894), and Joseph Conrad’s novel Heart of Darkness (1899). The comparative analysis demonstrates that the two texts have several common features both in terms of setting, thematic aspects and narrative technique. Both ”Glahns død” and Heart of Darkness take as a point of departure a riverboat journey into the jungle. Both texts thematize the differences between the European civilization and the “uncivilized” exotic world and focus on the contrasts between the civilized and the primitive life, the rational and the irrational behavior. Both stories are narrated by a male narrator personality that is strongly fascinated by another man, and in each case the text involves a partially unreliable witness type of narrator. The article describes some of these common features as modernist and confirms the position of both novels in early modernism.
Discovery of the chemical constituents, structural characteristics, and pharmacological functions of Chinese caterpillar fungus
Authors: Xu Chunhua , Wu Fenfang , Zou Zhicheng , Mao Longyi , Lin Shan
Published: May 2023

Caterpillar fungus (Cordyceps sinensis) has been widely used as a traditional Chinese medicine for several decades. It is essential to clarify the product composition, structural characteristics, and pharmacological functions of caterpillar fungus. In this review, we comprehensively and systematically summarized the various bioactive components isolated from caterpillar fungus, including nucleosides, d-mannitol, sterols, flavonoids, fatty acids, amino acids, vitamins, peptides, amides, proximate, and mineral composition. Meanwhile, peptides, nucleosides, and polysaccharides serve as the main active components in this genus, which possess immunomodulatory, antioxidant, anti-allergic, anti-tumor, anti-inflammatory, antibacterial, anti-malaria, and antifungal activities. Consequently, the active components of caterpillar fungus demonstrate a vital source of treatment for various diseases and can be used as possible leads for drug discovery. This article reviews the composition and pharmacological action of caterpillar fungus, which is the key to ensuring the safety and effectiveness of caterpillar fungus, and will be of interest for future research.
Fostering skills with chatbot-based digital tutors – training programming skills in a field study
Authors: Hobert Sebastian
Published: May 2023

Digital skills, particularly programming, have become a vital prerequisite for succeeding in today’s work life. Developing those skills is, however, a challenging task, as it requires perseverance, effort, and practice. To teach coding, individualized tutoring adapted to the novice programmers’ state of knowledge has evolved as the most promising learning strategy. However, offering sufficient learning support while practicing coding tasks is a challenge due to resource constraints. Following a three-cycle design science research approach, we developed a chatbot-based digital tutor that can support novice programmers using individualized, automated conversations based on adaptive learning paths and in-depth code analyses. In this article, we present the final version of the digital tutor software and report the findings of introducing it in a field setting over two entire lecture periods. We show that digital tutors can effectively provide individualized guidance in moments of need and offer high learning satisfaction in a long-term learning setting. This article expands the state of research by presenting insights into how students interact with a digital tutor over an entire lecture period. This also provides insights on how to design digital tutors for developing skills.
Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
Authors: Xu Wen , Liu Li , Cui Zhongqi , Li Mingyang , Ni Jinliang , Huang Nan , Zhang Yue , Luo Jie , Sun Limei , Sun Fenyong
Published: May 2023

Patients with castration-resistant prostate cancer (CRPC) often develop drug resistance after treatment with enzalutamide. The goal of our study was to identify the key genes related to enzalutamide resistance in CRPC and to provide new gene targets for future research on improving the efficacy of enzalutamide. Differential expression genes (DEGs) associated with enzalutamide were obtained from the GSE151083 and GSE150807 datasets. We used R software, the DAVID database, protein–protein interaction networks, the Cytoscape program, and Gene Set Cancer Analysis for data analysis. The effect of RAD51 knockdown on prostate cancer (PCa) cell lines was demonstrated using Cell Counting Kit-8, clone formation, and transwell migration experiments. Six hub genes with prognostic values were screened (RAD51, BLM, DTL, RFC2, APOE, and EXO1), which were significantly associated with immune cell infiltration in PCa. High RAD51, BLM, EXO1, and RFC2 expression was associated with androgen receptor signaling pathway activation. Except for APOE, high expression of hub genes showed a significant negative correlation with the IC50 of Navitoclax and NPK76-II-72-1. RAD51 knockdown inhibited the proliferation and migration of PC3 and DU145 cell lines and promoted apoptosis. Additionally, 22Rv1 cell proliferation was more significantly inhibited with RAD51 knockdown than without RAD51 knockdown under enzalutamide treatment. Overall, six key genes associated with enzalutamide resistance were screened (RAD51, BLM, DTL, RFC2, APOE, and EXO1), which are potential therapeutic targets for enzalutamide-resistant PCa in the future.
A green sorptive extraction method (HiSorb-TD-GC-MS) for determining the extra virgin olive oil (EVOO) aroma profile
Authors: Fella Panagiota , Stylianou Marinos , Agapiou Agapios
Published: May 2023

A headspace high sorptive extraction (HS-HiSorb) Thermal Desorption-Gas Chromatography-Mass Spectrometry (TD-GC-MS) method was developed and optimized for the determination of the volatile profile of extra virgin olive oil (EVOO). The HS-HiSorb extraction parameters of temperature, sample mass, stirring rate, and adsorption time were optimized by applying the one-factor-at-a-time (OFAT) approach. A total of 21 multi-varietal olive oil samples were collected from four different olive mills in Cyprus during the harvesting period 2020–2021. Seventy-six volatile organic compounds (VOCs) were identified and semi-quantified, belonging to several chemical categories such as hydrocarbons (31) three of which are terpenes, aldehydes (22), carboxylic acids (6), ketones (5), esters (4), alcohols (3), ethers (2), furans (2), and others (1). Aldehydes (40.20 %) and hydrocarbons (41.08 %) represented the main components of olive oil’s volatile profile. The overall concentrations of VOCs in the samples ranged from 8.73 to 39.81 mg/kg. The HiSorb-TD-GC-MS method was evaluated in terms of repeatability and linearity for selected VOCs. Repeatability was performed at three different concentrations (1, 10, and 100 ppbv), and the relative standard deviation (RSD) ranged from 2.21 to 15.86 %. The calibration curves of (E)-2-hexenal, 1-penten-3-one, nonanal, and hexanal were developed to evaluate the linearity range. The results were satisfactory, with the correlation coefficient (R
2) greater than 0.98. Finally, the limitations of the method are mentioned and discussed.
Deutschlands Energieversorgungsrisiko vor Russlands Angriff auf die Ukraine: Ein empirischer Vergleich mit den G7-Staaten
Authors: Frondel Manuel , Hansteen Sven , Krieg Marielena , Schmidt Christoph M.
Published: May 2023

Der russische Angriff auf die Ukraine im Februar 2022 und die darauf folgende rasante Steigerung der Energiepreise haben die Sicherheit der Energieversorgung in Deutschland und Europa wieder in den öffentlichen und politischen Fokus gerückt. Vor diesem Hintergrund quantifizieren Manuel Frondel, Sven Hansteen, Marielena Krieg und Christoph M. Schmidt die rohstoffspezifischen Risiken Deutschlands in der Versorgung mit Erdöl, Steinkohle und Erdgas seit Ende der siebziger Jahre sowie das Risiko der Energieversorgung für Deutschland insgesamt. Es folgt ein einordnender Vergleich mit den übrigen G7-Staaten. Dabei zeigt sich, dass das Risiko der Energieversorgung dem von Frondel und Schmidt (2009) konzipierten Indikator zur Messung der langfristigen Energieversorgungssicherheit zufolge seit dem Ende der siebziger Jahre stark gestiegen ist. Dies geht vor allem auf die massive Zunahme der Rohöl-, Steinkohle- und Erdgasimporte aus Russland bei einem gleichzeitigen Rückgang der heimischen Anteile an der Versorgung mit Erdöl, Steinkohle und Erdgas zurück. Der Beitrag illustriert, wie eine stärkere Diversifizierung der Importe von Energierohstoffen hinsichtlich der Bezugsländer sowie der Energierohstoffe und -technologien die Sicherheit der Energieversorgung erhöhen könnte.
First investigations on a CHON UNEX process
Authors: Simonnet Marie , Muller Lucas , Sittel Thomas , Weßling Patrik , Müllich Udo , Geist Andreas , Panak Petra J.
Published: May 2023

This paper presents first investigations on a novel An(III), Ln(III), Cs(I) and Sr(II) co-extraction conceptual process using a CHON solvent composed of the calixarene crown-ether MAXCalix and the diglycolamide TODGA in a 1-octanol/kerosene diluent. The co-extraction is followed by a sequential stripping of (1) Cs(I) and Sr(II), (2) An(III) and (3) Ln(III).
Idempotent operator and its applications in Schur complements on Hilbert C
*-module
Authors: Karizaki Mehdi Mohammadzadeh , Moghani Zahra Niazi
Published: May 2023

The present study proves that

T

T

is an idempotent operator if and only if

R

(

I
−

T

∗

)

⊕
R

(

T

)

=
X

{\mathcal{ {\mathcal R} }}\left(I-{T}^{\ast })\oplus {\mathcal{ {\mathcal R} }}\left(T)={\mathcal{X}}

and

(

T

∗

T

)

†

=

(

T

†

)

2

T

{\left({T}^{\ast }T)}^{\dagger }={\left({T}^{\dagger })}^{2}T

. Based on the equivalent conditions of an idempotent operator and related results, it is possible to obtain an explicit formula for the Moore-Penrose inverse of 2-by-2 block idempotent operator matrix. For the 2-by-2 block operator matrix, Schur complements and generalized Schur complement are well known and studied. The range inclusions of operators and idempotency of operators are used to obtain new conditions under which we can compute the Moore-Penrose inverse of Schur complements and generalized Schur complements of operators.
Optimization of green extraction process of Cinnamomum camphora fruit dye and its performance by response surface methodology
Authors: Qi Yiqing , Liu Guangyu , Zhang Zhi , Zhou Ziwen
Published: May 2023

Natural dyes are widely available and mainly extracted from natural plants with green, safe, and sustainable characteristics. This study used Cinnamomum camphora fruit peel as the raw material under the premise of minimizing chemical reagents and employed the microwave-extraction method to extract the dyes from C. camphora fruit peel. The dye extraction conditions were optimized using response surface software via the Box-Behnken model to formulate a response surface test protocol. The results showed that optimizing the experimental conditions by the response surface method was reliable. The optimal extraction condition was found to be material-liquid ratio 1:20 (g: mL), microwave time 90 s, and microwave power 420 W. It is of practical application value to improve the extraction quantity of C. camphora fruit dye. At the same time, the infrared spectrum and HPLC-MS analysis of Cinnamomum camphora fruit dye were analyzed, and the stability of the dye was tested.
Contemporary Left Main Percutaneous Coronary Intervention: A State-of-the-art Review
Authors: Showkathali Refai , Yalamanchi Radha Priya
Published: May 2023

The majority of the left ventricular myocardium is supplied by the left main coronary artery. Atherosclerotic obstruction of the left main coronary artery therefore leads to significant myocardial jeopardy. Coronary artery bypass surgery (CABG) has been the gold standard for left main coronary artery disease in the past. However, advancements in technology have established percutaneous coronary intervention (PCI) as a standard, safe and reasonable alternative to CABG, with comparable outcomes. Contemporary PCI of left main coronary artery disease comprises careful patient selection, accurate technique guided by either intravascular ultrasound or optical coherence tomography and – if necessary – physiological assessment using fractional flow reserve. This review focuses on current evidence from registries and randomised trials comparing PCI with CABG, procedural tips and tricks, adjuvant technologies and the triumph of PCI.
Two Holes in One: A Rare Case of Congenital Mitral Valve Anomaly
Authors: Quetulio Ma Liza R , Llabado Giselle Ann E , Pineda Anne Marie Kathryn I , Sison Jorge A , Cajigal Jennelyn M
Published: May 2023

Double orifice mitral valve (DOMV) is a rare anomaly, characterised by a mitral valve with a single fibrous annulus resulting in two orifices. Since its discovery in the late 19th century, around 200 cases have been reported. In the Philippines, this mitral valve anomaly has not been reported in literature. The authors are reporting this case to provide information in identifying DOMV using 2D and 3D imaging. The case involves a 26-year-old Filipino man with an incidental finding of an isolated double-orifice mitral valve. Additional imaging using 2D and 3D transoesophageal echocardiography was performed to assess the mitral valve morphology, function and possible associated anomalies. The en face view of the mitral valve showed a complete bridge of tissue extending from the middle of the anterior to the posterior leaflet, creating medial and lateral orifices. The patient presented with an isolated DOMV; hence, no intervention was necessary. However, long-term follow-up is advised.
Effectiveness and quality of life in lung cancer, pre-, post- and perioperative rehabilitation – A review
Authors: Abidi Yafet , Fekete Mónika , Farkas Árpád , Horváth Alpár , Varga János Tamás
Published: May 2023

Functional conditions like lung function and exercise capacity are important limiting factors of chest surgery in lung cancer with co-morbidities (chronic obstructive pulmonary disease (COPD) and other chronic respiratory diseases). Pulmonary rehabilitation has a favourable effect on the cardiovascular system, metabolism, respiratory and peripheral muscles and lung mechanics. Our aim was to assess the role of pre-, post- and peri-operative pulmonary rehabilitation in lung cancer in this review. We sought to size up the importance of pulmonary rehabilitation in patients undergoing surgery with or without (neo)adjuvant treatment, radiotherapy, chemotherapy, chemoradiotherapy, major physiological impairments and complications. Searches were performed in PubMed and ClinicalTrials.gov databases using the terms “exercise”, “rehabilitation”, “small cell lung cancer”, “non-small cell lung cancer”, “exercise capacity”, “chest surgery” and “quality of life” from inception to February 7th, 2022. Pulmonary rehabilitation has been recognized as an effective intervention to reduce lung cancer related symptoms and improve the pulmonary function, lung mechanics, chest kinematics, respiratory- and peripheral muscle function, physical activity and quality of life (QoL) of the patients. In conclusion, this review shows positive, highly encouraging and effective results of pulmonary rehabilitation in terms of the patients' lung function, functional mobility and quality of life. The tools for complex pulmonary rehabilitation have evolved considerably over the past two decades, thus this research has been conducted on a variety of studies about this subject and serves as a synthesis of the systematic and meta-analytic reviews.