bluuebunny/crossref_metadata_2025 huggingface dataset:
Trombectomía endovascular ecoguiada como alternativa en el manejo de la enfermedad arterial periférica. Reporte de dos casos
Authors: Sendoya Jesus David , Gómez Jaime Enrique , Conrado-Jiménez Héctor , Bautista Ana María
Published: April 2024

Resumen
Introducción. Usualmente el tratamiento de la enfermedad arterial periférica (EAP) es quirúrgico convencional o endovascular guiado mediante angiografía o ultrasonido. Existen reportes del uso del sistema de aterectomía y trombectomía mecánica Rotarex® y/o del ultrasonido dúplex (UD) como guías para trombectomías de forma separada; sin embargo, la combinación de ambos dispositivos representa una gran ventaja al convertirse en una opción con buena tasa de éxito que podría emplearse en el manejo de diferentes tipos de patologías.
Presentación de los casos. Se presentan dos casos de pacientes con antecedente de colocación de stent infrapoplíteo, quienes asistieron al servicio de urgencias de un hospital universitario de Bucaramanga (Colombia) por claudicación intermitente, discromía y dificultad en la marcha (índice tobillo-brazo en examen físico de 0.3 y 0.6). En ambos pacientes se evidenció trombosis del stent mediante dúplex arterial, por lo que se les realizó angioplastia con sistema Rotarex® guiada por UD, logrando resultados clínicos y hemodinámicos satisfactorios en el postoperatorio. Los pacientes fueron dados de alta a los 4 y 6 días después del procedimiento y en ninguno de los dos casos hubo seguimiento posterior al egreso.
Conclusiones. La trombectomía con sistema Rotarex® guiada por UD se plantea como una alternativa viable, real y costo-efectiva en pacientes con EAP. Se recomienda implementar este tipo de estrategias con el fin de realizar trabajos con mayor poder estadístico para el análisis de los resultados y que permitan obtener conclusiones reproducibles sobre tasas de éxito, permeabilidad y salvamento de la extremidad.
Transición epidemiológica y los desafíos fiscales para garantizar el derecho a la salud: Latinoamérica 2000-2016
Authors: Guevara Zapata Tomas Alfonso , Lizardo Zelaya Nelson A.
Published: April 2024

Objetivo Analizar el efecto del envejecimiento de la población y las enfermedades no trasmisibles sobre las finanzas públicas, en Honduras, Nicaragua, Costa Rica, Chile y Uruguay.
Materiales y Métodos Se realizó un estudio descriptivo de corte transversal no experimental. Se utilizaron datos de las variables gasto público en salud como porcentaje del producto interno bruto, esperanza de vida del nacer, tasa de mortalidad del menor de cinco años, tasa de mortalidad por enfermedades trasmisibles y tasa de mortalidad por enfermedades no trasmisibles, obtenidos del 2000 al 2016. Se aplicó un modelo econométrico de vectores autorregresivos bayesianos, que superó las diferentes pruebas para probar su robustez, estabilidad, ausencia de tendencias, especificidad y nivel de significancia menor del 5 %.
Resultados La tasa de mortalidad por enfermedades no trasmisibles tuvo una mayor incidencia en los países de bajos ingresos, lo cual se atribuyó al acelerado envejecimiento de la población. Esta situación generará una mayor demanda en los presupuestos nacionales, los cuales son limitados en estos países para la atención en salud.
Conclusiones Los hallazgos resaltan la importancia de orientar las políticas públicas de salud hacia la prevención de las enfermedades no trasmisibles, especialmente en los países con recursos limitados. Es fundamental la búsqueda del espacio fiscal para financiar las actividades para el abordaje de los factores de riesgo potencialmente modificables de las enfermedades no trasmisibles para garantizar el derecho a la salud y mejorar la calidad de vida de las personas de mayor edad.
Intoxication with psychoactive substances as a cause of paediatric hospital admissions: an observational study
Authors: Kosiorek Dorota , Lewko Jolanta , Romankiewicz Ewa , Lewko Karolina , Sierżantowicz Regina
Published: April 2024

Introduction and objective: Psychoactive substances intoxication among children and adolescents still poses a significant problem. Objective: The aim of the study was to assess paediatric patients intoxicated with psychoactive substances, who were admitted to a children’s hospital and their history of comorbidities. Materials and methods: This retrospective study assessed medical records of paediatric patients hospitalised in the Provincial Specialist Children’s Hospital in Olsztyn in the period from January 1, 2016 to December 31, 2018. The study included a group of 303 patients aged 0–18 years, diagnosed with intoxication with psychoactive substances. Results: In the analysed period, 303 paediatric patients were admitted due to intoxication with psychoactive substances, accounting for 0.45% of all hospitalised patients. The mean age of the patients was 14.83 ± 2.88 years. Among them there were 158 (52.15%) girls and 145 (47.85%) boys. Conclusions: Among children, poisoning occurs most often outside home (party, public place, plot, park). Medications and alcohol are the most common psychoactive substances used by adolescents. In the analysed period, poisonings in young people between 15 and 16 years of age were most often caused by alcohol consumption, while poisoning with other psychoactive substances most often occurred between 17 and 18 years of age. Patients with one comorbid disease were found more likely to use psychoactive substances compared to others, while patients with more than one comorbid disease use psychoactive substances and mixed drugs. Patients without comorbidities are more likely to consume alcohol.
APPROACH TO THE AUTOMATIC CREATION OF AN ANNOTATED DATASET FOR THE DETECTION, LOCALIZATION AND CLASSIFICATION OF BLOOD CELLS IN AN IMAGE
Authors: Kovalenko S. M. , Kutsenko O. S. , Kovalenko S. V. , Kovalenko A. S.
Published: April 2024

Context. The paper considers the problem of automating the creation of an annotated dataset for further use in a system for detecting, localizing and classifying blood cells in an image using deep learning. The subject of the research is the processes of digital image processing for object detection and localization.

Objective. The aim of this study is to create a pipeline of digital image processing methods that can automatically generate an annotated set of blood smear images. This set will then be used to train and validate deep learning models, significantly reducing the time required by machine learning specialists.

Method. The proposed approach for object detection and localization is based on digital image processing methods such as filtering, thresholding, binarization, contour detection, and filling. The pipeline for detection and localization includes the following steps: The given fragment of text describes a process that involves noise reduction, conversion to the HSV color model, defining a mask for white blood cells and platelets, detecting the contours of white blood cells and platelets, determining the coordinates of the upper left and lower right corners of white blood cells and platelets, calculating the area of the region inside the bounding box, saving the obtained data, and determining the most common color in the image; filling the contours of leukocytes and platelets with said color; defining a mask for red blood cells; defining the contours of red blood cells; determining the coordinates of the upper left and lower right corners of red blood cells; calculating the area of the region within the bounding box; entering data about the found objects into the dataframe; saving to a .csv file for future use. With an unlabeled image dataset and a generated .csv file using image processing libraries, any researcher should be able to recreate a labeled dataset.

Results. The developed approach was implemented in software for creating an annotated dataset of blood smear images

Conclusions. The study proposes and justifies an approach to automatically create a set of annotated data. The pipeline is tested on a set of unlabelled data and a set of labelled data is obtained, consisting of cell images and a .csv file with the attributes “file name”, “type”, “xmin”, “ymin”, “xmax”, “ymax”, “area”, which are the coordinates of the bounding box for each object. The number of correctly, incorrectly, and unrecognised objects is calculated manually, and metrics are calculated to assess the accuracy and quality of object detection and localisation.
METHOD FOR DETERMINING THE BIT GRID OVERFLOW OF A COMPUTER SYSTEM OPERATING IN THE SYSTEM OF RESIDUAL CLASSES
Authors: Yanko A. S. , Krasnobayev V. A. , Nikolsky S. B. , Kruk O. O.
Published: April 2024

Context. Consideration of a set of examples of practical application of the procedure for identifying overflow of the bit grid of a computer system operating in a non-positional number system in residual classes. The object of the study is the process of processing data represented in the residual class system.

Objective. The goal of the work is to consider and analyze examples of the bit grid overflow definition of a computer system when implementing the operation of adding two numbers in a system of residual classes based on the application of a method for determining the bit grid overflow, based on the use of the concept of number rank.

Method. The specificity of the functioning of a computer system in a system of residual classes requires the implementation of not only modular operations, but also requires the implementation of additional, so-called non-modular operations. Non-modular operations include the operation of determining the overflow of the bit grid of a computer system in the system of residual classes. In a non-positional number system in residual classes, implementing the process of detecting overflow of the bit grid of a computer system is a difficult task to implement. The method considered in the work for determining the overflow of the bit grid is based on the use of positional features of a non-positional code of numbers in the system of residual classes, namely the true and calculated ranks of a number. The process of determining the overflow of the result of the operation of adding two numbers in the system of residual classes has been studied, since this arithmetic operation is the main, basic operation performed by a computer system.

Results. The developed methods are justified theoretically and studied when performing arithmetic modular operations of addition, subtraction and multiplication using tabular procedures.

Conclusions. The main advantage of the presented method is that the process of determining the overflow of the bit grid can be carried out in the dynamics of the computing process of the computer system, i.e. without stopping the solution of the problem. This circumstance makes it possible to reduce the unproductive expenditure of the computer system in the system of residual classes. In addition, this method can be used to control the operation of adding two numbers in the residual class system. This increases the reliability of obtaining the true result of the operation of adding two numbers in the system of residual classes.
La pintura mural en la obra de Luis Alberto Acuña
Authors: Carrizosa-Posada Diego
Published: April 2024

La pintura mural en la obra de Luis Alberto Acuña, escrito por Diego Carrizosa Posada se refiere principalmente al análisis histórico e iconográfico de once pinturas murales que realizó el maestro Acuña desde 1959 hasta 1990. El contenido de las diferentes páginas trata temas como: un perfil biográfico del maestro, el desarrollo del muralismo en México, la influencia que recibió en su pensamiento y en su arte por parte de dicho movimiento artístico y los inicios de la pintura mural en Colombia. Comprende, además, textos críticos que se refieren al legado del maestro, los cuales fueron realizados por reconocidos historiadores, críticos de arte, curadores y gestores culturales como William López, Álvaro Medina, Jorge Morales Gómez, Christian Padilla y Eduardo Serrano; lo anterior se complementa con relatos de familiares y descendientes del maestro Acuña que dan a conocer su aspecto humano. El prólogo es escrito por el notable historiador y humanista Medófilo Medina. Este libro es del interés de estudiantes de pregrado, posgrado y profesionales de las disciplinas de antropología, arqueología, artes plásticas, artes visuales, estudios culturales, estudios literarios, estudios de patrimonio cultural, ciencias naturales, historia e historia del arte. Puesto que en los resultados que emergen de las metodologías de investigación histórica e iconográfica, que como se dijo, son implementadas para examinar los murales pintados por Luis Alberto Acuña, surgen contenidos que atañen a los estudios antes mencionados.
Investigar la comunicación
Authors: Rodríguez-Sánchez Adriana , García-Bustamante Elva Mónica
Published: April 2024

Este libro reúne diferentes textos que buscan resolver interrogantes relacionados con la comunicación étnica e indígena, los medios escolares, la comunicación organizacional, la comunicación de Gobierno y las prácticas comunicativas llevadas a cabo por colectivos de comunicación en Colombia. Los capítulos que componen el libro fueron escritos por miembros de la Asociación Colombiana de Investigación en Comunicación (ACICOM), y son producto de las investigaciones desarrolladas por los autores. Investigar la comunicación: entre prácticas, organizaciones, territorios y medios, es un proyecto editorial que se enmarca en el interés de ACICOM en promocionar diálogos e intercambios de saberes; contribuir al desarrollo de la investigación en los campos de la comunicación, el periodismo y las ciencias sociales y, de manera especial, promover las investigaciones alrededor de problemáticas relacionadas con el derecho a la comunicación, la libertad de expresión y de pensamiento, el pluralismo político y la diversidad cultural en Colombia.
Riscos ocupacionais associados à doença renal crônica de origem não tradicional (DRCnt) no Brasil: é hora de nos aprofundarmos em um problema negligenciado
Authors: Buralli Rafael Junqueira , Albuquerque Polianna L M Moreira , Santo Cintia da Espiritu , Calice-Silva Viviane , Nerbass Fabiana Baggio
Published: April 2024

Resumo Nas últimas décadas, uma epidemia de doença renal crônica (DRC) tem sido associada a fatores ambientais e ocupacionais (estresse térmico decorrente de cargas de trabalho elevadas em altas temperaturas e exposição a produtos químicos, como agrotóxicos e metais), denominada DRC de origem não tradicional (DRCnt). Esta revisão descritiva tem como objetivo apresentar evidências recentes sobre estresse térmico, agrotóxicos e metais como possíveis causas de DRCnt e fornecer uma visão geral das estratégias brasileiras de regulamentação, fiscalização e vigilância sanitária relacionadas. Os trabalhadores brasileiros são comumente expostos a condições extremas de calor e outros fatores de risco de DRCnt, incluindo o aumento da exposição a agrotóxicos e metais. Além disso, há uma falta de regulamentação e fiscalização, políticas públicas e estratégias adequadas para proteger a saúde renal dos trabalhadores em relação aos principais fatores de risco. É provável que a DRCnt seja uma causa significativa de DRC no Brasil, uma vez que a etiologia da doença é desconhecida em muitos pacientes e diversas condições para seu desenvolvimento estão presentes no país. Estudos epidemiológicos devem ser realizados para explorar associações causais e estimar o impacto do calor, dos agrotóxicos e dos metais na DRCnt no Brasil. Além disso, as políticas públicas devem priorizar a redução da exposição dos trabalhadores e a promoção de sua saúde e segurança.
Prevalence and factors associated with inadequate work ability among community health workers in Montes Claros, Minas Gerais state, Brazil: a cross-sectional study, 2018
Authors: Anjos Jamile Pereira Dias dos , Freitas Ronilson Ferreira , Almeida Karine Suene Mendes , Caldeira Antônio Prates , Popoff Daniela Araújo Veloso , Rocha Josiane Santos Brant
Published: April 2024

ABSTRACT Objective To estimate the prevalence and analyze factors associated with inadequate work ability among community health workers (CHWs). Methods This was a cross-sectional study conducted with CHWs, from July to October 2018, in Montes Claros, state of Minas Gerais, Brazil; work ability, sociodemographic, occupational, and clinical factors were investigated; prevalence ratios (PRs) with 95% confidence intervals (95%CI) were calculated using Poisson regression. Results Of the 675 CHWs, 25.8% (95%CI 22.7;29.2) showed inadequate work ability; length of service greater than five years (PR = 1.64; 95%CI 1.24;2.18), poor health status (PR = 2.10; 95%CI 1.56;2.83), depressive symptoms (PR = 1.98; 95%CI 1.54;2.55) and voice disorders (PR = 1.85; 95%CI 1.26;2.73) were associated with the event. Conclusion There was a high prevalence of inadequate work ability, associated with occupational and clinical factors.
Prevalência e fatores associados à capacidade inadequada para o trabalho entre agentes comunitários de saúde de Montes Claros, Minas Gerais: estudo transversal, 2018
Authors: Anjos Jamile Pereira Dias dos , Freitas Ronilson Ferreira , Almeida Karine Suene Mendes , Caldeira Antônio Prates , Popoff Daniela Araújo Veloso , Rocha Josiane Santos Brant
Published: April 2024

RESUMO Objetivo Estimar a prevalência e analisar fatores associados à capacidade inadequada para o trabalho entre agentes comunitários de saúde (ACS). Métodos Estudo transversal realizado com ACS, no período de julho a outubro de 2018, em Montes Claros, Minas Gerais, Brasil; foi investigada a capacidade para o trabalho, fatores sociodemográficos, laborais e clínicos; razões de prevalência (RPs) com intervalos de confiança de 95% (IC95%) foram calculadas por regressão de Poisson. Resultados Dos 675 ACS estudados, 25,8% (IC95% 22,7;29,2) apresentaram capacidade inadequada para o trabalho; tempo de serviço superior a cinco anos (RP = 1,64; IC95% 1,24;2,18), percepção do estado de saúde ruim (RP = 2,10; IC95% 1,56;2,83), sintomas depressivos (RP = 1,98; IC95% 1,54;2,55) e distúrbios da voz (RP = 1,85; IC95% 1,26;2,73) estiveram associados ao evento. Conclusão Houve prevalência elevada de capacidade inadequada para o trabalho, associada a fatores laborais e clínicos.
Multimorbidade e uso de serviços de saúde em população diagnosticada com covid-19 em município da região Sul do Brasil, 2020-2021: estudo transversal
Authors: Delpino Felipe Mendes , Vieira Yohana Pereira , Duro Suele Manjourany , Nunes Bruno Pereira , Saes Mirelle de Oliveira
Published: April 2024

Resumo Objetivo: Analisar a associação entre multimorbidade e uso de serviços de saúde em uma população diagnosticada com covid-19, no Sul do Brasil. Métodos: Estudo transversal, utilizando-se dados de um estudo longitudinal realizado na cidade de Rio Grande, estado do Rio Grande do Sul, Brasil, em 2021, com todos os indivíduos adultos diagnosticados com covid-19; análises descritivas foram realizadas e apresentadas como proporções com intervalos de confiança de 95% (IC95%); a regressão de Poisson foi realizada e relatada como razão de prevalências (RP), para avaliar a associação entre multimorbidade e utilização de serviços de saúde. Resultados: Dos 2.919 participantes, 40,4% apresentavam multimorbidade (≥ 2 doenças); os resultados ajustados mostraram que indivíduos com multimorbidade (3 ou mais doenças) apresentaram maior probabilidade de utilização da maioria dos serviços avaliados (RP = 3,21; IC95% 1,40;7,37) em unidades de pronto-socorro. Conclusão: A multimorbidade esteve associada à utilização de diferentes tipos de serviços de saúde.
LA RÚBRICA EN EL PROCESO DE ENSEÑANZA-APRENDIZAJE EN PLATAFORMAS EDUCATIVAS
Authors: Llerena-Espinoza Edith María , Garro-Aburto Luzmila Lourdes , Taipe-Poma Angelica Norma , Ocampo-Pizarro Saúl Rafael
Published: April 2024

Las rúbricas, herramientas esenciales para una evaluación objetiva, impulsan un aprendizaje autónomo y reflexivo, clave en el desarrollo de competencias. El objetivo de la revisión efectuada fue analizar la literatura científica sobre el uso de rúbricas para evaluar a los estudiantes a través de plataformas educativas virtuales en los diferentes niveles y carreras en las instituciones educativas en el período 2018-2022. Se realizó una revisión sistemática bajo las directrices PRISMA. Se consultaron bases de datos como Scopus, Web of Science, SciELO y Science Direct, identificando inicialmente 127 artículos. Mediante criterios estrictos de inclusión y exclusión, centrados en la relevancia, calidad metodológica y actualidad, se seleccionaron 19 artículos para un análisis detallado. Los resultados mostraron un aumento significativo en la investigación sobre rúbricas en diferentes niveles educativos y un interés creciente en su uso como herramientas de evaluación formativa. Se concluyó que las rúbricas son fundamentales para una interacción dinámica, activa y dirigida en el proceso educativo, al promover un aprendizaje autónomo y reflexivo que contribuyó al desarrollo de competencias. La revisión proporciona una comprensión integral del estado actual y la efectividad de las rúbricas en la educación virtual.
De las políticas estatales al reconocimiento de las víctimas y sus derechos: un estado de la cuestión
Authors: López-Getial Alejandra
Published: April 2024

El presente artículo de revisión presenta un acercamiento a la producción académica elaborada en las últimas dos décadas en torno al contexto histórico y normativo que soporta las políticas de reparación integral a víctimas, con el propósito de identificar el alcance que han tenido estas políticas en el efectivo reconocimiento de las víctimas y sus derechos. Se utilizó una metodología de corte cualitativo a través del método de revisión documental; en el proceso de revisión se consultaron las bases de datos de Scopus, CEPAL, Dialnet, JSTOR, Google Scholar; y el análisis de la información se realizó a través del programa Atlas.ti. Lo que permitió ver el análisis de estos marcos jurídicos fue la respuesta históricamente tardía del Estado para responder, atender y reparar el universo de víctimas que ha dejado el conflicto armado. En este sentido, el artículo señala que pese a las condiciones de vulnerabilidad en las que se han encontrado las víctimas históricamente, al no ser destinatarias de políticas públicas oportunas dirigidas a su reconocimiento y atención, estas han logrado organizarse en torno a una serie de procesos e iniciativas para hacer frente a los daños e impactos generados por la violencia.
VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels
Authors: Zhu Chunyu , Cheng Yameng , Yu Yao , Zhang Yanning , Ren Guiyun
Published: April 2024

Head and neck squamous cell carcinoma (HNSCC) is a globally prevalent and lethal cancer form which precise mechanisms remain incompletely understood. Increasing evidence suggests that N6-methyladenosine (m6A) plays a crucial role in cancer progression. This study aimed to explore the biological function of m6A modification and vir-like m6A methyltransferase associated (VIRMA) inHNSCC. We conducted an analysis of VIRMA expression in HNSCC cells using The Cancer Genome Atlas (TCGA) database and employed reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blotting to assess its expression levels in HNSCC cell lines. Additionally,m6A levels in HNSCC cells were quantified, and the correlation between VIRMA expression levels and the clinical and pathological features of other genes was analyzed. Upon knocking down VIRMA levels, we assessed HNSCC cell proliferation, migration, and invasion and validated downstream genes using RT-qPCR and western blot. Our findings suggested that VIRMA, as an m6A-related regulator, may significantly influence HNSCC progression by regulating ubiquitin protein ligase E3 component N-recognin 5 (UBR5) through m6A modification. Therefore, VIRMA may serve as a prognostic biomarker.
Paraffin embedding of tissue specimen | HuBMAP | JHU-TMC v1
Authors: Sang Han Kyu , Wu Pei-Hsun , Sunshine Joel , Kiemen Ashley , James Miklhail , Reddy Sashank , Wirtz Denis
Published: April 2024

The standard for tissue embedding is to ensure tissue samples are appropriately oriented and embedded on the “cut edge” or flattest edge available. Histology laboratories that receive mostly soft tissues prefer a “softer” paraffin as opposed to laboratories that receive hard specimens, such as skin, which would require a “harder” paraffin.
USE OF GIS AS AN INNOVATIVE DIRECTION OF FUNCTIONING OF THE RECREATION AND TOURISM SYSTEM OF THE SKOLIVSK BESKIDS NATIONAL NATURE PARK
Authors:   Lviv State University of Physical Culture named after Ivan Boberskyi, Lviv, Ukraine, Khudoba Khudoba Volodymyr , Stefanyshyn Zoryana ,   Lviv State University of Physical Culture named after Ivan Boberskyi, Lviv, Ukraine
Published: April 2024

The purpose of the article is to consider the conceptual foundations of the formation and functioning of recreational and touristic systems of nature protection territories on the example of the national nature park "Skolivski Beskydy", to justify the use of GIS as a direction of innovative development of the park's recreational and touristic system. Method. The research is based on the application of general scientific methods, such as analysis, synthesis, comparison, classification, generalization, as well as special cartographic, modeling, etc. methods. The results. The article examines the existing approaches to the functioning of spatial recreational (tourist) systems, investigates the general principles and regularities of the formation of tourist and recreational systems on the territory of national natural parks. The structure and tasks of the recreation and tourism system of the National nature park "Skolivski Beskydy" were considered. The functions of the main functions of the recreational and tourist system of the researched park are highlighted. Measures for the innovative development of the recreational and tourist system of the national natural park are proposed. Scientific novelty. The expediency of using GIS as a direction of innovative development of the recreational and tourist system of the national natural park is substantiated. The practical significance of the work lies in the possibility of using the geo-informational recreational-tourism system of the national natural park for scientific, recreational-tourist, ecological-educational, management purposes.
THE CONCEPT OF CRIMINAL PROCESS AND ITS SCIENTIFIC AND PRACTICAL SIGNIFICANCE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Pohoretskyi M.A.
Published: April 2024

The article is devoted to the study of problematic issues of the doctrinal definition of the concept of criminal procedure. The author makes a comparative legal analysis of the definitions of «criminal procedure», «criminal proceedings», «criminal proceedings» in legal acts and scientific doctrines of Western countries and Ukraine in the genesis aspect. It is substantiated that the concept of criminal procedure should be used in four senses: as a branch of law, as a branch of science, as a separate type of legal activity, and as an academic discipline. Criminal procedure as an independent branch of public law is a set of legal norms enshrined in the Constitution of Ukraine, international treaties in force and ratified by the Verkhovna Rada of Ukraine, the Code of Criminal Procedure and other laws of Ukraine, which regulate legal relations between participants to criminal proceedings. Criminal procedure, as an independent branch of legal science, studies criminal procedural relations arising in connection with criminal proceedings and constitutes a system of concepts, ideas, views, ideas, concepts, doctrines, theories that reveal the essence of criminal procedure, the laws of its emergence, functioning and development. Criminal procedure as an independent type of legal activity of the parties to criminal proceedings (prosecution and defense), the court and other subjects of criminal procedure regulated by criminal procedural law, which consists in clarifying the circumstances of a criminal offense, making procedural decisions and resolving procedural issues related to their implementation in order to resolve a conflict arising from the commission of this offense. The author proves the need for the gradual introduction of the institute of pre-trial advocacy at this stage of criminal proceedings to strengthen the adversarial principles of pre-trial investigation. Criminal procedure as an academic discipline is studied in higher education institutions of legal profile for training lawyers of various specializations. Its subject matter is criminal procedural science, criminal procedural law and the practice of its application. The author substantiates that the doctrinal definition of the concept of criminal procedure in the above four meanings as the initial fundamental doctrinal category of the conceptual apparatus of criminal procedural science is of scientific and practical importance, and also reveals the content of these meanings.
PARTICIPATION OF THE DEFENDER DURING NOTIFICATION OF A SUSPECT IN THE PRE-JUDICIAL INVESTIGATION
Authors:   Kharkiv National University of Internal Affairs, Kharkiv, Ukraine, Kucher V. O. , Baidyk O. A. ,   Law Office «Aleksandr Baidyk and partners»
Published: April 2024

The article deals with the problematic issues of the defense counsel’s participation when informing a person of suspicion during the investigation of criminal offenses regarding different categories of people. The purpose of the article is to study the theoretical and practical issues related to the participation of the defense attorney during the notification of suspicion to certain categories of persons, to identify problematic aspects and, based on this, to formulate scientifically based proposals for the improvement of criminal procedural legislation and the practice of its application. The author found out that among the main terms defined in Art. 3 of the Criminal Procedure Code of Ukraine, the legislator does not disclose the concept of «suspicion», due to which difficulties in both theoretical and practical directions arise in law enforcement. The analysis of the legal nature of the specified definition made it possible to propose the author’s definition, according to which suspicion is proposed to be understood as a well-founded assumption (based on the evaluation of the evidence available at a certain point in time) of the investigator, inquirer and/or prosecutor about the involvement of a person in the commission of a specific criminal offense, procedurally recorded in the notification of suspicion, which must be checked for refutation or confirmation. It is emphasized that the subject of criminal offenses in the field of official activity is an official (special subject) who has a responsible or particularly responsible position. In this regard, a special procedure for criminal proceedings is provided at the legislative level, in which the institution of the notification of suspicion is of key importance, and is also a way of integrating the norms of other branches of legislation, which regulate the public-legal status of the specified persons. Therefore, branch legislation in combination with the norms of criminal procedural law creates a holistic mechanism for the implementation of guarantees of independence and inviolability of such persons. With the help of a systematic and logical-structural analysis of the extra-final procedural legislation of Ukraine, as well as the legal positions of the ECtHR, it has been proven that the notions of notification of suspicion and making a false notification of suspicion, which are not identical, should be distinguished. For a clearer understanding of this procedure, the author proposes to improve the current legislation with provisions that a judge can be notified of a suspicion of a criminal offense only by the Prosecutor General or his deputy. The Prosecutor General (acting Prosecutor General), his deputy, the head of the regional prosecutor’s office can instruct other prosecutors to notify the judge in writing of the suspicion.
GUARANTEES FOR THE PROTECTION OF JOURNALISTIC SOURCES IN THE APPLICATION OF TEMPORARY ACCESS TO THINGS AND DOCUMENTS
Authors: Lysachenko Y.I. , Denisenko G. V
Published: April 2024

The article is devoted to the study of guarantees of protection of journalistic sources when applying temporary access to things and documents in the criminal procedural law of Ukraine. Based on the analysis of the current criminal procedural legislation of Ukraine, the author defines the subject matter of journalistic secrecy, which is: 1) a source of information; 2) information which is held/received by a journalist or a media outlet with a view to its dissemination or use in their professional activities; 3) any other information (documents, records) which allow establishing a connection between a journalist and a source of information. The author establishes that the lack of proper judicial control over the legality of investigators’ claims, the formal approach to consideration of applications for temporary access to things and documents, and the impossibility of appealing against the relevant rulings on appeal create a risk of disclosure of information in the possession of a media outlet or a journalist and provided to them on condition that the authorship or source of information is not disclosed. It is proved that the use of temporary access to things and documents containing legally protected information, in particular, information in the possession of a media outlet or a journalist and provided to them on condition that the authorship or source of information is not disclosed, without a ruling of an investigating judge or a court is inadmissible. The European Court of Human Rights has determined in a number of decisions that disclosure of sources is acceptable only in exceptional cases when it comes to protecting vital interests. These include cases of sexual abuse of children, disclosure of particularly serious crimes, etc. However, the decision to disclose the source of information must be made by an independent and impartial judicial authority and must contain a detailed justification why the disclosure of journalistic «sources» of information outweighs the journalist’s right to keep them secret. It is important to emphasize the need to eliminate formalism in the consideration of motions for temporary access to things and documents, and especially in cases involving information containing legally protected secrets (in particular, the secrecy of journalistic sources). In such cases, the law requires that the investigating judge find a fair balance between the right to secure criminal proceedings for the purpose of to solve the crime and the right to keep secrets protected by law, in particular the secrecy of journalistic sources (see para. 1, part 1, Article 162, part 6, Article 163 of the CPC of Ukraine). In view of this, the practice of considering such motions within 5–5 minutes should be recognized as unacceptable. motions within 4–5 minutes, as this does not allow for a thorough familiarization with the case file, conduct an appropriate analysis, and make a reasoned decision.
The Origin of Biogenic Horizons in the Pleistocene Strata of Denisova Cave: Mineralogical and Geochemical Markers Help to Reconstruct the Sources of Matter
Authors:   Sobolev Institute of Geology and Mineralogy, Siberian Branch, Russian Academy of Sciences, Sokol E. V. , Nekipelova A. V. ,   Sobolev Institute of Geology and Mineralogy, Siberian Branch, Russian Academy of Sciences, Kozlikin M. B. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Shunkov M. V. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Kokh S. N. ,   Sobolev Institute of Geology and Mineralogy, Siberian Branch, Russian Academy of Sciences, Tikhova V. D. ,   Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Filippova K. A. ,   South Urals Federal Research Center of Mineralogy and Geoecology, Ural Branch, Russian Academy of Sciences, Danilenko I. V. ,   Sobolev Institute of Geology and Mineralogy, Siberian Branch, Russian Academy of Sciences, Khvorov P. V. ,   South Urals Federal Research Center of Mineralogy and Geoecology, Ural Branch, Russian Academy of Sciences
Published: April 2024

В статье представлены результаты исследования методами минералого-геохимического анализа среднеплейстоценовых осадков слоя 21 в центральном зале Денисовой пещеры на Алтае. Работа проведена с целью выявления комплекса типоморфных минералогических и геохимических характеристик, которые присущи специфическим черноокрашенным горизонтам или линзам и надежно отличают их от всех прочих типов отложений в Денисовой пещере. Впервые полученные минералого-геохимические характеристики черноокрашенных линз из основания слоя 21 сопоставлены с аналогичным набором признаков черноокрашенных горизонтов из голоценовой части разреза в восточной галерее пещеры. Сделаны выводы об условиях образования и наиболее вероятных источниках органических и органогенных материалов в подразделениях слоя 21. Определена сохранность геохимических меток в плейстоценовых осадках в сравнении с голоценовыми, где эти метки четко проявлены. Показано, что по набору вещественных характеристик, в частности, по высоким концентрациям азотсодержащего органического вещества, P, Zn, Cu, Cd, осадки черноокрашенных линз в слое 21 аналогичны биогенным осадкам из голоценовой части разреза в восточной галерее пещеры. В валовых пробах таких осадков зафиксированы многочисленные фрагменты хитина (экзоскелеты насекомых) и стяжения новообразованных Ca и Ca-Mg фосфатов. Специфические осадки определены как прослои гуано насекомоядных летучих мышей, претерпевшие глубокую биологическую переработку — биодеградацию. Сделан вывод о том, что в осадках Денисовой пещеры ряд разновозрастных черноокрашенных горизонтов и линз обладает единым комплексом геохимических меток и резко контрастирует со смежными слоями по фазовому, макро- и микроэлементному составу.
IMPLEMENTASI CCTV ONLINE UNTUK MENINGKATKAN PEMANTAUAN FASILITAS WARGA BANJAR SAMPALAN
Authors: Rudiastari Elina , Atmaja I Made Ari Dwi Suta , Bawa I Gusti Ngurah Bagus Catur , Indah Komang Ayu Triana , Sukerti Gusti Nyoman Ayu , Astawa I Nyoman Gede Arya
Published: April 2024

IMPLEMENTATION OF ONLINE CCTV TO IMPROVE MONITORING OF BANJAR SAMPALAN RESIDENTS' FACILITIESSampalan Hamlet is a tourist destination where many facilities and infrastructure have begun to be built. The problems faced by the Sampalan Traditional Banjar are that there is no supervision of the routes around the Banjar area, there is no documentary evidence that can be used to analyze accidents that occur around the Banjar, there is no supervision to avoid acts of theft at the temple and there is no supervision of the social activities of residents which was carried out in Banjar. The solution offered in this community service activity for the problems experienced is the installation of CCTV. This service activity aims to help access monitoring and supervision of the Banjar area to increase the security and comfort of residents and visiting tourists. This method of implementing community service activities is implemented into three main stages, namely preparation, implementation and evaluation. The results of the evaluation through a questionnaire resulted in 71.4 percent of residents stating that the installed CCTV was very useful, and 50 percent of residents stated that the presence of CCTV greatly facilitated monitoring and supervision around the Banjar.Dusun Sampalan merupakan destinasi wisata dimana fasilitas serta infrastruktur sudah mulai banyak dibangun. Permasalahan yang dihadapi Banjar Adat Sampalan yaitu belum adanya pengawasan terhadap jalur disekitar areal Banjar, tidak adanya bukti dokumentasi yang dapat digunakan untuk menganalisa peristiwa kecelakaan yang terjadi di sekitar Banjar, tidak adanya pengawasan untuk menghindari tindakan pencurian di pura serta tidak adanya pengawasan terhadap aktivitas sosial warga yang dilakukan di Banjar. Solusi yang ditawarkan dalam kegiatan pengabdian kepada masyarakat ini untuk permasalahan yang dialami adalah pemasangan CCTV. Tujuan dari kegiatan pengabdian ini adalah membantu akses monitoring dan pengawasan areal Banjar sehingga meningkatkan keamanan dan kenyamanan warga serta wisatawan yang berkunjung. Metode pelaksanaan kegiatan pengabdian kepada masyarakat ini diimplementasikan menjadi tiga tahapan utama yaitu persiapan, pelaksanaan dan evaluasi. Hasil evaluasi melalui kuisioner menghasilkan 71,4 persen warga menyatakan CCTV yang terpasang tersebut sangat bermanfaat serta 50 persen warga menyatakan bahwa adanya CCTV sangat mempermudah monitoring dan pengawasan di sekitar Banjar.
The Role of Biochemical Markers in Cataractogenesis. Literature Review
Authors: Alkharki L. , Matyuschenko A. G.
Published: April 2024

Lens transparency is determined by both cellular and subcellular levels of its organization. Abnormalities of its size, uniformity of shape and correct arrangement of the fibers lead to the scattering of light falling on the lens. At the same time, its normal transparent proteins turn into a cloudy, coagulated, insoluble form, and undergo denaturation. Therefore, the preservation of lens transparency is possible only with a certain chemical composition, achieved by a strict balance of all metabolism links. There are many different hypotheses about the disease etiology. It is known that intraocular fluid has a low content of proteins and an increased concentration of chloride-, lactate-, ascorbatanions in its composition, in contrast to blood plasma. It cannot be ruled out that this is due to the selective permeability of the blood–ocular barrier, which consists of non-pigmented epithelial cells of the ciliary body. In addition, the modification of molecular composition and constitutional imbalance in the intraocular fluid often causes of pathological processes development in the anterior segment of the eye. The blood-ocular barrier makes the eye an immune-privileged organ. However, many diseases, surgical interventions and eye injuries can lead to blood-ocular barrier damage. This causes to inflammatory effector cells and molecules inducing a cascade of reactions, which in turn results in irreversible fibrotic changes in the lens substance. In this regard, it becomes necessary to search for new reliable methods of determining the level of certain biochemical agents in intraocular structures, as well as establishing reference values for strategically important biomarkers of cataract development. This review presents modern views on biochemical markers imbalance in the anterior chamber aqueous humor and the lens, which contributes to its substance opacity.
Modern Approaches in the Diagnosis and Treatment of Corneal Lesions in Children. Clinical Case
Authors: Markova E. Yu. , Nikitina A. E. , Navruzalieva D. Ya. , Maychuk D. Yu. , Golovin A. V. , Taevere M. R.
Published: April 2024

Objective. To present the results of successful treatment of a patient with corneal lesions caused by Acanthamoeba spp. receiving long-term conservative treatment.

Methods. A child with corneal ulcer of mixed etiology with a history of wearing orthokeratology lenses and long-term ineffective treatment in Moscow hospitals was referred to Moscow in S.N. Fyodorov Eye Microsurgery Federal State Institution. The patient underwent a complete ophthalmological examination, including confocal microscopy.

Results. The condition of the child’s eye was extremely severe, live and dead cysts of Acantamoeba spp were found in the central zone of the cornea at the depth of 113–149 μm, Along with intensive conservative treatment with catheterisation of the retrobulbar space and introduction of drugs into the irrigation system, UV corneal crosslinking was performed twice.

Conclusion. Treatment according to the proposed method allowed to achieve excellent results: there was no corneal syndrome, complete epithelialisation of the corneal defect, disappearance of corneal edema and remission of uveitis manifestations. According to the data of confocal microscopy there is no growth of microflora and acanthamoeba cysts.
Psychological Empowerment Exploration on Innovative Work Behavior: The Role of Transformational Leadership as Mediator
Authors: Aristana I Nengah , Wibawa I Wayan Sucipta , Wisnawa I Made Bayu
Published: April 2024

Research aims: The objective of this research is to explore the effect of psychological empowerment on innovative work behavior with transformational leadership as a moderator.Design/Methodology/Approach: This research was designed using a quantitative approach where data was collected using questionnaires distributed to 190 employees of export SMEs in Bali. The gathered data was examined using Smart PLS 3.2.9 software.Research findings: The research found that psychological empowerment and its dimensions positively affected innovative work behavior. In addition, transformational leadership fully moderated the link between psychological empowerment and innovative work behavior. The limitation of the research indicated bias due to self-assessment reports. Meanwhile, the practical implications contribute to expanding understanding of the role of transformational leadership as a moderator. Thus, leaders have a reference in policy making.Theoretical Contribution/Originality: The theoretical contribution of this research contributes to the knowledge of on innovative work behavior by exploring psychological empowerment.Practitioners/Policy Implications: Practical implications contributed to expanding understanding of the moderating role of transformational leadership. Hence, leaders have a reference in policy making.Research Limitations/Implications: The sample used is still limited to the export SME sectors in Bali. This research uses a causality approach. Thus, the data reported is self-assessment.
Anti-tumor Effect of Shikonin on S180 tumor - Bearing Mice
Authors: Cheng Guodong
Published: April 2024

Objective: To investigate the changes of cell cycle and the content of P53 protein in S180 cells by using the specific fluorescent probe to identify the biological target to be measured according to the change of the fluorescence signal. The results showed that Shikonin had good anti-tumor effect. Methods: Cell cycle changes and P53 protein content in S180 cells were detected by flow cytometry. Results: With the increase of Shikonin dose, S180 cells G1 and S phase content gradually increased, it can be inferred Shikonin action in cells, and the cells can be blocked in G1 and S phase. With the increase of the dose of Shikonin, the expression of P53 protein increased. This suggests that Shikonin may up-regulate P53 activity and induce apoptosis. Conclusion: From the experimental results, we can see that Shikonin has a good antitumor effect in vivo.