bluuebunny/crossref_metadata_2025 huggingface dataset:
Economic Evaluations of Next-Generation Precision Oncology: A Critical Review
Authors: Weymann Deirdre , Pataky Reka , Regier Dean A.
Published: August 2018

Purpose

Precision oncology has the potential to improve patient health and reduce treatment costs. Yet the up-front cost of genomic testing with next-generation sequencing (NGS) technologies can be prohibitive. Our study is a structured review of economic evaluations of precision oncology informed by NGS. The aim is to characterize the availability and scope of economic evidence.

Materials and Methods

We searched Medline (PubMed), Embase (Ovid), and Web of Science databases for English-language full-text peer-reviewed articles published between 2000 and 2016. We focused our search on articles that estimated the benefit of precision oncology in relation to its costs. We excluded studies that did not undertake full economic evaluations or did not focus on NGS technologies. We reviewed all included studies and summarized key methodological and empirical study characteristics.

Results

Fifty-five economic evaluations met our inclusion criteria. The number of published studies increased steadily, from three studies between 2005 and 2007 to 26 between 2014 and 2016. Most studies evaluated multiplex panels (86%). We found testing was frequently used to predict prognosis (67%), to diagnose patients (24%), or to identify targeted therapeutic options (7%). Methods and cost effectiveness differed according to NGS technology, test strategy, and cancer type. Deterministic and probabilistic analyses were typically used to characterize parameter and decision uncertainty (91% and 75%).

Conclusion

Although the availability of economic evidence examining precision oncology increased over time, methods used often did not align with current guidelines. Future evaluations should undertake extensive sensitivity analysis to address all sources of uncertainty associated with rapidly changing NGS technologies. Furthermore, additional research is needed evaluating the cost effectiveness of more comprehensive next-generation technologies before implementing these on a wider scale.
Re-inforcing the cell death army in the fight against breast cancer
Authors: Oudenaarden Clara R. L. , van de Ven Robert A. H. , Derksen Patrick W. B.
Published: August 2018

Metastatic breast cancer is responsible for most breast cancer-related deaths. Disseminated cancer cells have developed an intrinsic ability to resist anchorage-dependent apoptosis (anoikis). Anoikis is caused by the absence of cellular adhesion, a process that underpins lumen formation and maintenance during mammary gland development and homeostasis. In healthy cells, anoikis is mostly governed by B-cell lymphoma-2 (BCL2) protein family members. Metastatic cancer cells, however, have often developed autocrine BCL2-dependent resistance mechanisms to counteract anoikis. In this Review, we discuss how a pro-apoptotic subgroup of the BCL2 protein family, known as the BH3-only proteins, controls apoptosis and anoikis during mammary gland homeostasis and to what extent their inhibition confers tumor suppressive functions in metastatic breast cancer. Specifically, the role of the two pro-apoptotic BH3-only proteins BCL2-modifying factor (BMF) and BCL2-interacting mediator of cell death (BIM) will be discussed here. We assess current developments in treatment that focus on mimicking the function of the BH3-only proteins to induce apoptosis, and consider their applicability to restore normal apoptotic responses in anchorage-independent disseminating tumor cells.
Dynamic association of human mRNP proteins with mitochondrial tRNAs in the cytosol
Authors: Jády Beáta E. , Ketele Amandine , Kiss Tamás
Published: August 2018

Cytoplasmic localization, stability, and translation of mRNAs are controlled by their dynamic association of numerous mRNA-binding (mRNP) proteins, including cold shock domain (CSD)-containing proteins, heterogeneous nuclear ribonucleoproteins (hnRNPs), and serine/arginine-rich (SR) proteins. Here, we demonstrate that the most abundant human mRNP protein, the CSD-containing Y-box-binding protein 1 (YBX1), the closely related YBX3 protein, and other mRNP proteins, such as SRSF1, SRSF2, SRSF3, hnRNP A1, and H, specifically and efficiently interact with overlapping sets of mitochondrial tRNAs (mt tRNAs). In vitro reconstitution and in vivo binding experiments show that YBX1 recognizes the D- and/or T-stem–loop regions of mt tRNAs through relying on the RNA-binding capacity of its CSD. Cell fractionation and in vivo RNA–protein cross-linking experiments demonstrate that YBX1 and YBX3 interact with mt tRNAs in the cytosol outside of mitochondria. Cell fractionation and fluorescence in situ hybridization experiments provide evidence that mitochondrial autophagy promotes the release of mt tRNAs from the mitochondria into the cytoplasm. Association of mRNP proteins with mt tRNAs is highly dynamic; it is rapidly increased upon transcription inhibition and decreased during apoptosis. Although the cytoplasmic function of mt tRNAs remains elusive, their dynamic interactions with key mRNA-binding proteins may influence cytoplasmic mRNA stability and/or translation.
Structure of the 30S ribosomal decoding complex at ambient temperature
Authors: Dao E. Han , Poitevin Frédéric , Sierra Raymond G. , Gati Cornelius , Rao Yashas , Ciftci Halil Ibrahim , Akşit Fulya , McGurk Alex , Obrinski Trevor , Mgbam Paul , Hayes Brandon , De Lichtenberg Casper , Pardo-Avila Fatima , Corsepius Nicholas , Zhang Lindsey , Seaberg Matthew H. , Hunter Mark S. , Liang Mengling , Koglin Jason E. , Wakatsuki Soichi , Demirci Hasan
Published: August 2018

The ribosome translates nucleotide sequences of messenger RNA to proteins through selection of cognate transfer RNA according to the genetic code. To date, structural studies of ribosomal decoding complexes yielding high-resolution data have predominantly relied on experiments performed at cryogenic temperatures. New light sources like the X-ray free electron laser (XFEL) have enabled data collection from macromolecular crystals at ambient temperature. Here, we report an X-ray crystal structure of the Thermus thermophilus 30S ribosomal subunit decoding complex to 3.45 Å resolution using data obtained at ambient temperature at the Linac Coherent Light Source (LCLS). We find that this ambient-temperature structure is largely consistent with existing cryogenic-temperature crystal structures, with key residues of the decoding complex exhibiting similar conformations, including adenosine residues 1492 and 1493. Minor variations were observed, namely an alternate conformation of cytosine 1397 near the mRNA channel and the A-site. Our serial crystallography experiment illustrates the amenability of ribosomal microcrystals to routine structural studies at ambient temperature, thus overcoming a long-standing experimental limitation to structural studies of RNA and RNA–protein complexes at near-physiological temperatures.
The World Bank & financing tuberculosis control, 1986-2017
Authors: Rahi Manveer , Fernandes Genevie , Winters Janelle , Sridhar Devi
Published: August 2018

Background: Tuberculosis (TB) is among the leading contributors to global mortality and morbidity from infectious diseases and has had a major socioeconomic cost in recent history. The World Bank is a leading institution for global health governance and financing, but little research has concentrated on the role of the World Bank in global tuberculosis control.

Methods: We tracked the development of the World Bank’s policies and associated financial flows for tuberculosis control. First, we performed a scoping review of both published and grey literature. Second, we used the Bank’s Projects & Operations database to construct a dataset of all World Bank projects with funding allocated to the “Tuberculosis” theme from 1986 to 2017.  Finally, we analysed the World Bank’s funding patterns alongside wider funding for tuberculosis using the Institute of Health Metrics and Evaluation’s Development Assistance for Health database.

Results: We identified four periods in the World Bank’s involvement in global tuberculosis control, from the recognition of tuberculosis as a global health issue to the creation of a global coalition against tuberculosis. Between 1986 and 2017 the World Bank undertook 79 projects with financing from its core lending divisions with a tuberculosis control theme or focus. Within the 79 projects the Bank committed 19.6% of funding, or $0.9bn, towards tuberculosis control. The World Bank has been involved in increasingly vertical programming with a growing proportion of project funding invested into tuberculosis control over time. However, after the formation of private-public partnerships against tuberculosis in 2002 such as the Global Fund to Fight HIV/AIDS, TB and Malaria, the Bank’s core financing decreased and private-public partnerships provided increasing levels of substitutive financing for tuberculosis control.

Conclusions: The World Bank has been pivotal in leading global financing, garnering advocacy and creating widespread coalition in the battle against tuberculosis control in recent decades.
Non-Standard Mathematical Tasks for the Development of the Creative Abilities of Primary School Pupils
Authors: Кочурова Елена , Kochurova Elena
Published: August 2018

In the article some types of text tasks and different forms of work with them are considered, allowing to ensure the development of mathematical functional literacy of younger schoolchildren, to reveal their creative abilities. The content of the section “Working with text tasks” of the curriculum in mathematics is analyzed. Particular attention is paid to specific ways and methods of work, as a result of which children have the opportunity to show creativity in the lessons of mathematics.
Features of Creative Tasks in Literary Reading Lessons
Authors: Хомякова Ирина , Khomyakova Irina
Published: August 2018

The article reveals the methodological methods that allow the most active development of the creative abilities of younger schoolchildren in literary reading classes. Among them: speech workouts; work on the characteristics of literary heroes, drawing up a plan and annotations to the text; its analysis and retelling; creation of mini-compositions; selection of illustrations for a literary work, taking into account the content of the full text and fragment; comparison of related works of literature and fine arts.
Children-Adult Communities in the Conditions of the Orthodox School of General Education (on the Example of the Implementation of the Volunteer Project “Orthodox Camp”)
Authors: Комогорцева Т. , Komogorceva T.
Published: August 2018

The article deals with the problem of intergenerational interaction between children and adults that is topical for modern society. The work on raising children in the course of the project “Volunteer Orthodox Camp”, organized on the basis of the ValdayIversky Monastery, was highlighted. Conditions are described that contribute to a deeper familiarization of students in the general education school with the traditions of Orthodox culture, principles on the basis of which constructive relations between people in the process of work and interpersonal communication are built. The significance of the volunteer project in shaping the personality of the schoolchild, the education of his respect for universal values, ensuring the successful socialization of the younger generation is revealed.
Cognitive function and its associations in older adults from Amazonas, Brazil
Authors: Tinôco Maria Antonieta de Campos , Gouveia Élvio Rúbio , Ihle Andreas , Kliegel Matthias , Jurema Jefferson , Machado Floramara Teles , Odim Angeany Pinto , Muniz Bárbara Régia , Ribeiro Euler Esteves , Gouveia Bruna Raquel , Freitas Duarte Luís
Published: August 2018

The objectives of this study were: (1) to investigate the age-related differences in cognitive function (CF), nutritional status (MNA), physical activity (AF), quality of life (QoL), depression, social satisfaction (SS) and socioeconomic status (SES), and (2) to explore the relationships between CF and the previous variables. This cross sectional study included 268 men and 433 women (aged 71.4 ± 7.0 years). CF was determined with the Cognitive Telephone Screening Instrument (COGTEL) and the Mini-Mental State Examination (MMSE). Correlates were as follows: Mini Nutritional Assessment (MNA), PA (Baecke questionnaire modied for older adults), Quality of life (QoL SF- 12), Geriatrics Depression Scale (GDS), Satisfaction and Social Support Scale, and Socioeconomic status (SES). All instruments were applied in a face to face interview. An independent t-test identied signicantly higher scores in young-old adults (≤ 69 years) for CF (p < 0.001), PA (p = 0.046) and SES (p = 0.007), compared to old-old adults (≥ 70 years). e results of multiple linear regression analysis indicated that the most signicant CF correlates were SES (β = 0.45; p < 0.001), age (β = -0.12; p < 0.001), SS (β = 0.12; p = 0.001), GDS (β = -0.11; p = 0.003) and QoL (β = 0.08; p = 0.017). The overall regression model explained 36% of the total variance in the COGTEL. The oldest and the more depressed adults obtained lower scores for FC. The present study suggests that, between the correlates studied, SES was the strongest predictor in the explanation of CF in older adults.
O combate à doença do sono nas colônias portuguesas na África: medicina sob o signo do racismo e do darwinismo social (1901-1932)
Authors: Figueiredo Moura da Silva Ewerton Luiz
Published: August 2018

A doença do sono ou tripanossomíase humana africana teve sua importância na agenda imperialista europeia, pois foi considerada um importante obstáculo para a formação de seus impérios coloniais na África. Neste cenário, as autoridades portuguesas, desejosas em defender as colônias do país frente à concorrência europeia e em promover a ação “civilizadora” de Portugal, enviaram missões de estudo e de combate das chamadas doenças tropicais nas possessões ultramarinas do país. As estratégias de domínio colonial não passaram somente pelo controle das doenças presentes nas colônias, mas também no esforço para combater os saberes e as práticas associados à doença e à cura das sociedades africanas, tratadas na época como racialmente inferiores pelos poderes europeus.
Three-Dimensional Cellular Raman Analysis: Evidence of Highly Ordered Lipids Within Cell Nuclei
Authors: Ramamurthy Bhagavathi , Cohen Stanley , Canales Mark , Coffman Frederick D.
Published: August 2018

Striking levels of spatial organization exist among and within interphase cell chromosomes, raising the possibility that other nuclear molecular components may also be organized in ways that facilitate nuclear function. To further examine molecular distributions and organization within cell nuclei, we utilized Raman spectroscopy to map distributions of molecular components, with a focus on cellular lipids. Although the vast majority of cellular lipids are associated with membranes, mapping the 2870/2850 cm−1 lipid peak ratios revealed that the most highly ordered lipids within interphase cells are found within cell nuclei. This finding was seen in cells from multiple tissue types, noncancerous cells, and in cancer cell lines of different metastatic potential. These highly ordered lipids colocalize with nuclear chromatin, are present throughout the nuclear volume, and remain colocalized with chromatin through mitosis, when the nuclear envelope has dissociated. Phosphatidylinositol is a major component of the highly ordered lipids. The presence of phosphatidylinositol and other lipids in the nuclear interior is well established, but their highly ordered packing has not been reported and represents a unique finding. The molecular interactions involved in the formation and maintenance of these highly ordered lipids, and their potential effects on nuclear activities, remain to be discovered.
Event Review
Authors: Khan Ali
Published: August 2018

Has Tokyo Fashion Lost its Moment?: Off the ramp collaborations, designer parties, AND THE USUAL spectacle of street fashion save an otherwise inconsistent outing
Exhibition Review
Authors: Richards Harriette
Published: August 2018

Rei Kawakubo/Comme des Garçons: Art of the In-Between, Metropolitan Museum of Art, New York, 4 May–4 September 2017
Faktor Risiko Tuberkulosis Paru Terkonfirmasi Bakteriologis
Authors: Anam Mohamad Syarofil , Syaputri Hanifa , Dadiyanto Dwi Wastoro , Sidhartani Magdalena
Published: August 2018

Latar belakang. Insiden tuberkulosis (TB) paru terkonfirmasi bakteriologis pada anak mulai meningkat di Indonesia.Tujuan. Menganalisis faktor risiko TB paru terkonfirmasi bakteriologis pada anak. Metode. Penelitian kasus-kontrol menggunakan data catatan medik pasien TB anak di RSUP dr. Kariadi Semarang periode tahun 2014-2015. Kelompok kasus adalah pasien TB anak yang ditemukan kuman dari pemeriksaan sputum dengan BTA dan atau tes cepat molekuler (TCM). Kelompok kontrol adalah pasien TB yang terdiagnosis secara klinis. Analisis menggunakan Chi-square dan multivariat.Hasil. Sebanyak 74 pasien TB anak dilakukan analisis, 37 subyek di masing-masing kelompok. Gambaran Rontgen paru berat dan riwayat kontak TB merupakan faktor risiko (OR 3,08; CI: 1,11-8,50, p=0,027) (OR 2,85; CI:1,08-7,55, p=0,032). Jenis kelamin, usia, status gizi, gejala demam, batuk dan tes tuberkulin, bukan merupakan faktor risiko TB terkonfirmasi bakteriologis. Kesimpulan. Riwayat kontak dan gambaran Rontgen toraks yang berat merupakan faktor risiko TB paru terkonfirmasi bakteriologis pada anak.
Auxílio-reclusão em tempos de cultura do medo
Authors: Siqueira Tiago Adami , Serau Junior Marco Aurélio
Published: August 2018

Trata-se de ensaio voltado para a análise da importância do auxílio-reclusão em umavsociedade dominada pela cultura do medo. O artigo contextualiza a proteção previdenciária enquanto um direito fundamental, bem como a importância do auxílio-reclusão para o equilíbrio social e a manutenção econômica dos dependentes de segurados do Regime Geral de Previdência Social. O ensaio também discute a visão de parcela da sociedade a respeito desse benefício previdenciário, acentuando a intolerância social na pós modernidade.
Human Proteome Project and Current Bioinformatics Status in Disease Diagnosis and Treatment
Authors: Anwar Pervez , Javed Ayesha , Amjad Izba , Arif Iqra , Sadiqa Attiqa , Akram Huria , Azhar Laraib
Published: August 2018

Human proteome project was revolutionized about 40 years ago with purpose of summarizing whole proteomic data at one place. It was launched after human genome project to map and observe all proteins. The goal related proteomic study is to draft the entire human proteome in disease diagnosis by using bioinformatics tools. Pillars of human proteome project provide different databases related to proteins at transcriptional and translational level. Human proteome organization(HUPO) published biology disease HUPO whose aim is to measure protein and proteome by life and processes related to human diseases. Different human organ like plasma, liver, brain and diabetic base project are used to characterize human disease and health. Major data resources accumulated in databases like peptides Atlas, GPMDB and neXtProt for proteins. Matrices of human proteome project identify and characterize the protein products as Post translational modification (PTM), splice various isoforms from 20,300 proteins. Matrices related to different years make proteomes counterpart by magnify the research biomedical community with high output of instruments and specimen pre-analytical protocols. CALIPHO multidisciplinary group provides information about protein complexities, interactions, function and structure complexities after Uniport and Swissprot. Different bioinformatics tools are used for structural and functional annotations of protein, disease diagnosis and mutations due to protein. Extensive study of human proteome project has been proved helpful in disease treatment at translational and post- translational levels. In future, human proteome project along with bioinformatics will include protein profiling, biomarkers, Mass spectrophotometer technique and cross analysis of different proteome projects.
Dimerization of the BASIC PENTACYSTEINE Domain in Plant GAGA-Factors is Mediated by Disulfide Bonds and Required for DNA-Binding.
Authors: Theune Marius L. , Hummel Sabine , Jaspert Nina , Lafos Marcel , Wanke Dierk , Wanke Dierk
Published: August 2018

GAGA-binding proteins in plants are encoded by the BARLEY B-RECOMBINANT / BASIC PENTACYSTEINE (BBR/BPC) family, which can be spilt into several groups on the basis of sequence divergence. The proteins of the different groups share an evolutionary conserved BASIC PENTACYSTEINE (BPC) domain at their very C-terminus that is important for DNA binding. Hallmark of this domain are five Cysteines at defined positions and spacing, which are considered to form a zinc-finger like structure that is involved in GAGA-motif recognition. Here, we report the formation of stabile homodimers between Arabidopsis thaliana group I member BPC1 or between group II member BPC6 in SDS-PAGE. Serial mutations of the highly conserved five Cysteines in the BPC domain of Arabidopsis thaliana BPC1 were tested for their capacity to bind to GAGA-motifs by DPI-ELISA. Our results do not support the idea of a direct involvement of these residues in making physical contact with the DNA, e.g. by formation of a zinc-finger structure. Instead, the data implies an indispensable function for the five Cysteines in homodimerization and stabilization of the protein structure by disulfide bonds. Accordingly, protein folding and structure prediction suggests the formation of a scaffold for dimerization that is supported by three intermolecular and one intramolecular S-S bond. The high degree of conservation between the BPC domains from the different groups and from different species denotes that this role for the five Cysteines might be evolutionary retained.
Modelling Development in Plant Anatomy
Authors: Korn Robert W.
Published: August 2018

Four rules for good anatomical modeling of plants are explored. First, the cell is the reference source for modelling at any level. Second, developmental signaling occurs between few cells, about 12. Third, rules of are algorithmic and not simply physical forces as proposed by Thompson. Finally, it is desirable to proposed a likely alternative model that can be discounted. The main value of modelling is selecting data for modelling rather than the by a biased investigator.
Landscapes and Throughscapes in Italian Forest Worlds: Thinking Dramatically about the Anthropocene
Authors: Mathews Andrew S.
Published: August 2018

Phenomenological descriptions of landscapes, trees, and terraces, combined with oral history and historical ecology, find traces of industrialization, plant disease, and forest fires in central Italian forests. Plant form, landscape form, and forest structure can be described through drawings that give resolutely partial descriptions of more-than-human encounters. This kind of knowledge of the landscape is potentially unstable and remade by the details that it contains. By using multiple methods for attending to more-than-human landscapes, we can learn to notice multiple throughscapes, landscape patterns that overlap and lie through each other, but which are linked to different histories. Multiplying histories means that rather than being seen as a single era, the Anthropocene can be understood as having many beginnings and coexisting histories that give rise to multiple futures.
Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in rats
Authors: Solihati N. , Purwantara B. , Supriatna I. , Winarto A.
Published: August 2018

The objective of this study was to determine histomorphological change of seminiferous tubules, sperm quality and testosterone level after administration and cessation of pegagan extract. The research used 4x2 factorial complete randomized design, the first factor was dose-administration duration and the second factor was cessation length of pegagan extract. Parameters consisted of degree of spermatogenesis, sperm quality (motility, concentration and abnormality), and testosterone level. The data were processed using analysis of variance and Duncan’s test. Results showed that there was no interaction between dose-administration duration and cessation length. There was no significant difference of dose-administration duration of pegagan on degrees of spermatogenesis, sperm motility and testosterone level. Cessation length did not significantly affect degrees of spermatogenesis, sperm motility, and testosterone level although these results indicated that cessation of pegagan extract for 12 days increased degrees of spermatogenesis and sperm motility, indicated the antifertility potency of pegagan extract. In conclusion, Pegagan extract has potency as anti-fertility agent although the degree of spermatogenesis, sperm quality and testosterone levels were still in the normal range for the reproductive process and not irreversible, and pegagan could be explored as an reversible anti-fertility agent.
Essential trace elements in meat, spleen and liver of Brahman Cross steers reared in intensive production system in Bandung, Indonesia
Authors: Lestiani D. D. , Santoso M. , Setyowati E. Y. , Kurniawati S. , Adventini N. , Damastuti E.
Published: August 2018

In this study the determination of micro mineral elements (selenium, iron and zinc) in meat, spleen and liver of beef were carried out. Brahman cross steers reared under intensive production system in feedlot for 87 days. Samples of meat, spleen and liver were collected from 16 steers aged 24-36 months with four types of feeding treatment, feeding without Se (group I) and feeding with additional supplementary of 0.3 ppm selenium for 25, 50 and 75 days (group II, III and IV, respectively). Samples characterization were carried out by instrumental neutron activation analysis (INAA) using irradiation facility in G.A Siwabessy Serpong reactor. Analysis results showed that there is an increasing of selenium content in meat and liver after 75 days feeding. The mean of selenium in liver for group I, II, III and IV were 0.13, 0.17, 0.20 and 0.31 mg/kg wet weight, respectively, while for liver were 0.43, 0.53, 0.60 and 0.70 mg/kg wet weight, respectively. The mean concentrations for iron in meat, spleen and liver were 11.85, 139, and 38.94 mg/kg, respectively, for zinc were 27.90, 21.70 and 25.27 mg/kg, respectively. In this study, the meat and liver contribute more than 100% of recommended daily allowance (RDA) of Se for children and adults. Spleen have contribution of RDA of Fe 53 to 154%, while the RDA of Zn is contributed mostly from meat by 21 to 56%.
Dynamics of an ecological system
Authors: Kant Shashi
Published: August 2018

In this paper, we investigate the deterministic and stochastic prey-predator system with refuge. The basic local stability results for the deterministic model have been performed. It is found that all the equilibrium points except the positive coexisting equilibrium point of the deterministic model are independent of the prey refuge. The trivial equilibrium point, predator free equilibrium point and prey free equilibrium point are always unstable (saddle point). The existence and local stability of the coexisting equilibrium point is related to the prey refuge.
The permanence and extinction conditions of the proposed biological model have been studied rigourously. It is observed that the stochastic effect may be seen in the form of decaying of the species. The numerical simulations for different values of the refuge values have also been included for understanding the behavior of the model graphically.
Hilbert space valued Gabor frames in weighted amalgam spaces
Authors: Poria Anirudha , Swain Jitendriya
Published: August 2018

Let{\mathbb{H}}be a separable Hilbert space. In this paper, we establish a generalization of Walnut’s representation and Janssen’s representation of the{\mathbb{H}}-valued Gabor frame operator on{\mathbb{H}}-valued weighted amalgam spaces{W_{\mathbb{H}}(L^{p},L^{q}_{v})},{1\leq p,q\leq\infty}. Also, we show that the frame operator is invertible on{W_{\mathbb{H}}(L^{p},L^{q}_{v})},{1\leq p,q\leq\infty}, if the window function is in the Wiener amalgam space{W_{\mathbb{H}}(L^{\infty},L^{1}_{w})}. Further, we obtain the Walnut representation and invertibility of the frame operator corresponding to Gabor superframes and multi-window Gabor frames on{W_{\mathbb{H}}(L^{p},L^{q}_{v})},{1\leq p,q\leq\infty}, as a special case by choosing the appropriate Hilbert space{\mathbb{H}}.
Effects of a 6-month balance intervention on postural control of preschoolers born with biological risk factors
Authors: Csirkés Zsolt , Bretz Károly , Jakab Katalin , Földi Rita F
Published: August 2018

Study aim: To investigate the effects of 6-month sensorimotor training on postural control of 5-6-year-old preschool children born with ‘biological risk factors’ (BRF). Material and methods: Sixty-four Hungarian preschoolers participated in this study, and were assigned to an experimental group (n = 17), control group 1 (n = 23) and control group 2 (n = 24). The experimental group (born with BRF) attended a 6-month balance intervention based on Ayres’ therapy, while control group 1 (born with BRF) and control group 2 (born with no BRF) fol­lowed the regular preschool schedule. Birth weight, gestational age at birth, Apgar score and other abnormalities during pregnancy and birth were considered to be BRF. A moveable platform (stabilometer) was used to examine the distance of center of pressure movements of all participants prior to the start and after the end of the intervention. The testing procedure was performed with four enjoyable tests in the same sequence (‘Mouse in the hole’, ‘Center’, ‘Christmas tree’, ‘Square painting’). Results: The balance intervention program resulted in significant improvements in postural control of the experimental group. In three of six variables the balance index scores of the intervention group approached the scores of their peers born without BRF, and they even had better performance in three of six variables. Conclusions: Balance training with instability training devices could help children born with BRF attain a higher level of inte­gration through the stimulation of tactile and balancing senses.
Modeling and robust control algorithms for a linear belt driven system
Authors: Minh Vu Trieu , Tamre Mart , Sekhri Even
Published: August 2018

This paper proposes the mathematical modeling and robust control algorithms for linear belt system with the help of sliding mode control approach. Due to the elasticity of the belt, the presence of frictions, and the un-modeled dynamics, conventional controllers cannot provide precise position control of carriage. Dealing with this kind of system, a robust controller is needed and the chattering-free sliding mode control (SMC) approach is used to design the robust controller. A belt stretching estimator is also incorporated into the control law. Simulations show that the system is free from chattering and robust to disturbances. The reference tracking position is performed with the minimal errors to an extent that can be considered negligible. The time for reaching the reference tracking position is very fast. The system is safe for all mechanical and electrical devices.
L’articolazione argomentativa di Plat.Soph. 237b7–239a11 e la natura delmedamos on
Authors: Aronadio Francesco
Published: August 2018

InSoph. 237b7–239a11 Plato lays out a sequence of arguments that are generally considered homogenous. An analysis of each argument can shed light on the need to differentiate their respective nature. Firstly, it will be shown that the arguments do not work only at the linguistic level, contrary to the way these passages are interpreted by most of commentators. The meta–linguistic nature of the third argument will be particularly emphasised. Secondly, it will be argued that the three arguments follow each other according to acrescendo. The implications of this argumentative structure will be specifically appreciated. Both these results of the analysis induce to attribute a crucial importance to the notion ofmedamos on: the arguments do not aim to definitively exclude the possibility of a Parmenidean non–being; they play a positive role within the inquiry of the Stranger of Elea, inasmuch the thematisation of Parmenidean non–being is seriously taken into account and embraced at this stage of the dialogue. In fact it is only through this dialectical step that the Stranger gains the chance to proceed in the direction of a relational ontology and a new concept of non–being. The positive role played by themedamos onpresupposes that this expression and the equivalent ones are not mere absurdities and can find place in the Platonic use of language; this implies that the notion ofmedamos onmust have a justification in the framework of Platonic relational ontology and conception of language. The consideration of this aspect eventually gives the opportunity to return to the three arguments and present an explanation of their positioning in that stage of the dialogue.
Index of Fossiliferous Localities of the Olešná Member, Klabava Formation (Lower Ordovician of the Prague Basin, Czech Republic)
Authors: Kraft Jaroslav , Mergl Michal , Hroch Tomáš , Kraft Petr
Published: August 2018

Thirty-two fossiliferous localities of the Olešná Member, a distinct unit of the Klabava Formation, are described. As we are able to find they represent all fossil sites of this unit ever been mentioned in publications. Fossil taxa from relevant papers are summarized and the historical names used for the localities are listed. Updated lists of fauna are compiled for each locality; based on them an overall list for the member is completed.
Towards a Democratic State in Palestine/Israel
Authors: Halper Jeff
Published: August 2018

International law provides guidelines for the acceptable behavior of states and, ideally, sanctions. It does not prescribe, however, political solutions to conflicts or set out blueprints for reconstituting an unjust political situation in forms that conform to it. While taking international law as a fundamental element defining the parameters of political settlements, this paper asks: what political program best translates its norms and values into concrete form? It explores the two-state solution, apartheid and the prospect of a single democratic state, the last conforming to international law and supported by the One Democratic State Campaign (ODSC).
Belligerent Occupation and ITS Discontents: On the Relationship between International Human Rights Law and Belligerent Occupation’s Law
Authors: Silingardi Stefano
Published: August 2018

Too many normative instances, that were originally external to the belligerent occupation’s regulatory framework have settled, over the last decades, into that body of law. I refer, for instance, to the Occupying Powers’ demand to intervene significantly in the economic, political and social life of the occupied territory in the light of the need to conduct populations subject to undemocratic regimes, or in very backward economic conditions, on the road to democracy and economic development; or to the expectations that the Occupying Powers fully implement some core human rights obligations incumbent upon them. However, because of the lack of useful information in the current legal framework of international humanitarian law about the scopes that should legitimately lead the activities of the Occupying Powers, these claims threatens to deprive of legal effect the statement that occupation would not implement any transfer of sovereignty to the occupant (the so called ‘sovereign-based’ approach laid down by Articles 42 and 43 of the Hague IV Regulations). After a brief explanation of the doctrinal foundations of belligerent occupation’s law in the broader picture of the more recent practice of Israel in the occupied Palestinian territories (with specific reference to the 2017 Law for the Regulation of Settlement in Judea and Samaria), the Article will focus on the analysis of the relationship between international human rights law (IHRL) and belligerent occupation’s law – in particular by stressing the risks that could arise when an Occupying Power decides to act in order to implement the right to self-determination of the occupied population. The aim is to investigate not only, form a de lege lata perspective, how the more recent practice of Occupying Powers has been influenced by IHRL but also, from a de lege ferenda perspective, to which extent (if any) human rights norms would contribute to fill the gaps and loopholes of the existing regulatory framework on belligerent occupation.
History and Politics and the Politics of History: Poland and Its
Museums of Contemporary History
Authors: Etges Andreas , Zündorf Irmgard , Machcewicz Paweł
Published: August 2018

The Polish museum landscape has turned into a battleground between politicians
and historians. Much of that has focused on the highly praised Museum of the
Second World War in Gdańsk which opened in March 2017. Its founding
director Pawel Machcewicz was dismissed when the conservative-nationalist party
“Law and Justice” came to power. The article and the interview
with Machcewicz discuss that story, the founding and exhibition design of other
Polish history museums as well as the politics of history in Poland and
beyond.
What Is (International) Public History?
Authors: Dean David , Etges Andreas
Published: August 2018

What is Public History? And why do we need a new journal? Co-editors of IPH David Dean and Andreas Etges introduce this new international journal and discuss their thoughts in why it is a timely intervention in the field. They explain the many unique features of IPH and review the contributions to this, the first issue.
Die Glaubwürdigkeit der Wikipedia
Authors: Hesse Wolfgang
Published: August 2018

Die Wikipedia ist sowohl hinsichtlich ihres Umfangs als auch hinsichtlich ihrer Nutzung die heute bedeutendste Enzyklopädie. Auch innerhalb der Wissenschaft spielt sie, vor allem als leicht zugänglicher Rechercheeinstieg, eine wichtige Rolle. In diesem Zusammenhang steht die Glaubwürdigkeit der Wikipedia immer wieder im Fokus, da ihre Inhalte nicht durch Fachexperten kontrolliert, sondern von jedermann ediert werden können. Jedoch ist innerhalb der Wikipediacommunity ein starkes Bemühen um Glaubwürdigkeit festzustellen. Anhand der Analyse ausgewählter Redaktionsprinzipien der Wikipedia und der Auswertung einer Fallstudie zur Erzeugung von Glaubwürdigkeit in der deutschsprachigen Wikipedia lassen sich Implikationen für Information Professionals ableiten. Besonders Bibliothekarinnen und Bibliothekare können durch ihren Zugang zu Literatur einerseits und mit ihren Recherchekenntnissen andererseits dabei helfen, die Glaubwürdigkeit der Wikipedia zu steigern.
Eurofound informiert über die Lebens- und Arbeitsbedingungen in der EU
Authors: Schmidt-Abbey Barbara , Mezger Erika
Published: August 2018

Die Europäische Stiftung zur Verbesserung der Lebens- und Arbeitsbedingungen (Eurofound) ist eine Agentur der Europäischen Union mit Sitz in Dublin, Irland. Als europäischer Informationsdienstleister stellt Eurofound Forschungsergebnisse, Daten, Informationen und Wissen über die Lebens- und Arbeitsbedingungen in der Europäischen Union bereit, um Strategien in der Arbeits- und Sozialpolitik auf europäischer Ebene weiterzuentwickeln. Ziel ist die Verbesserung der Lebens- und Arbeitsbedingungen in Europa. Dieser Artikel bietet einen Überblick über die Dienstleistungen, Arbeitsweise und intendierte Wirkungslogik dieser europäischen Dienstleistungsagentur. Dazu gibt er einen Ausblick auf die Gemeinsamkeiten und Unterschiede in den Arbeitsweisen anderer vergleichbarer EU-Agenturen und erläutert, wie sie zur EU-politikrelevanten Bereitstellung von wissenschaftlichen Informationen beitragen und miteinander kooperieren.
Climbing Sports Effect Specific Visual-Spatial Abilities
Authors: Pietsch Stefanie , Jansen Petra
Published: August 2018

Physically active people show better visual-spatial abilities than physically inactive people. Especially athletes with response times based on competition times, such as wrestling, outperform other athletes. This quasi-experimental study examines the relationship of long-term activity in sport climbing, which is a typical non-response time-based leisure activity, and mental rotation and spatial visualization performance. Climbers outperformed other athletes in mental rotation, but not in spatial visualization tasks. That could be based on their experience with mainly holistic movement patterns.
History
Authors: Doležalová Eva , Koldinská Marie Šedivá , Sekera Martin , Mezerová Jana , Junek Marek
Published: August 2018

The exposition named History will present the development of the Czech lands from the 9th century till the present. The exposition will be divided into two separate spaces – the Historical Building of the National Museum will house the history of the 9th–19th centuries and the New Building of the National Museum will house the history from the 20th century. Despite reflecting to a certain extent the traditional division of the Middle Ages, Early Modern Period, the “long” 19th century, and the 20th century, the narrative will be continuous without any artificial historical disruptions. We will debunk some historical myths and stereotypes. Emphasis will be laid on the presentation of items from the collections of the National Museum. A certain update will also be important, i.e. the presentation of ideas and symbols, that we refer to today. Parallel narratives will be nonetheless important, as they will show that history is not unambiguous and that certain events can be viewed from several different perspectives (e.g. the winner and the loser, nobleman and subject). Last but not least, we will address the issues of individual freedom and its limits.
Theory as a Platform for the Education of Museum Staff. Development of the Centre for the Study of Museology in the Years 1967–1982
Authors: Kirsch Otakar , Jagošová Lucie
Published: August 2018

The aim of the presented study is to bring together almost fifteen years of the Centre for the Study of Museology of the Charles University’s Faculty of the Arts at the National Museum in Prague (herein - after referred to as the Centre), one of the most important contemporary methodological and educational centres in the field of museology. The subject of interest will gradually become an analysis of the factors and phenomena that led to its establishment in 1967, including the theoretical concept of the head of the Centre, Jiří Neustupný, which became the starting point for the final form of its curriculum. In addition to outlining the structure for the curriculum for the students of Charles University’s daily study and for the museum staff and introducing personalities who have participated in educational activities, the text also deals with its non-teaching activities (such as research and methodological activities, cooperation within both the domestic and the international museum organisations, while collecting and publishing museological literature). The work was created to commemorate the 50th anniversary of the museological centre which is recognised by international authorities and, as the first one, this work seeks to map its development.
The Working Class Movement Museum Collection – Extensive Array of Objects, Archives and Books
Authors: Tothová Jolana
Published: August 2018

The Collection of the Working Class Movement Museum results from a fusion of three Prague museums – the Klement Gottwald Museum, the V. I. Lenin Museum and the Julius Fučík Museum, which were taken over and completed by the Working Class Movement Museum in 1990. For the reason of securing the completeness of the Collection, the Working Class Movement Museum donated it to the National Museum in 2014. The Collection of hundreds of thousands of items consists of collectibles (e.g. works of visual art, posters, military objects, flags and standards, honours and documents of social events and also photographic and film materials), archive records (some personal possessions of Klement Gottwald, Antonín Zápotocký, Julius and Gusta Fučík, a collection of the written materials and of the small prints and archives of the original museums) and library items (publications from the 19th and 20th centuries focused on the history of the social movements and the processes). This paper presents both the origins and the content of the Collection and summarises the process of its change of location and deposition and also the creation of the new concept regarding the treatment of the museum funds.
Paperless Archaeology on Castrum Novum
Authors: Paclíková Klára , Preusz Michal
Published: August 2018

Modern technology affects the development of the humanities, including the most traditional of the disciplines such as classical archaeology. We are looking for an answer to the question of whether high-tech could completely replace the basic tools without which we would not even imagine archaeology. Could pencil and paper completely disappear from the trench? We tested the principles regarding paperless archaeology on the exemplary research of the deserted Castrum Novum Roman Colony located in central Italy. The colony was founded in the 3rd century BC and disappeared in the 5th century AD. The discovery of the city occurred in the 18th century when the Pope decided to support the first excavations. Especially unique findings of sculptures became a feature of the Vatican Museums. After that the city was again forgotten. Only in the second half of the 20th century, have we managed to re-locate Castrum Novum. This resulted in the need for modern systematic archaeological research. Currently an extraordinary collaboration is bringing interesting discoveries and new perspectives for the Italian, the French and the Czech archaeologists.
The Part Played by Social Networks in the Activities of the Jewish Museum in Prague
Authors: Tejkal Jiří
Published: August 2018

The paper summarises the basic ways of working with social networks that are used by the Jewish Museum in Prague. It describes experiences with such networks as Facebook, YouTube, Instagram and Twitter, while special attention is also paid to the Tripadvisor Review Portal. Using specific examples, it assesses the benefits and the limitations that this way of communicating with the public provides.
Discovering Collections, Discovering Communities Conference Report
Authors: Radostová Kristýna
Published: August 2018

The main theme of the DCDC conference, held in November 2017 in Manchester, was understanding the value of culture and collections and the difference they make to visitors who participate in cultural programmes. Many international projects presented at the conference demonstrated why the arts and culture matter and served as an inspiration to all of the attendees.
Museums and Their International Audiences
Authors: Mikešová Pavla
Published: August 2018

The National Museum, the Centre for Presenting Cultural Heritage in cooperation with the Náprstek Museum of Asian, African and American Cultures, held on the 24th and the 25th October 2017 a specialised seminar entitled “Museums and Their International Audiences” focusing on the work of the museum staff with foreigners who are living in the Czech Republic and foreign visitors. The seminar presented innovative projects from the environments of museums and galleries that present the culture and the history of foreigners and national minorities who are living in the Czech Republic, it dealt with the role of museums in the field of integration of foreigners and with possibilities of cooperation with the non-profit sector in this area. On the second day of the seminar a specific intercultural skills training was held.