bluuebunny/crossref_metadata_2025 huggingface dataset:
Time and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging
Authors: Pieszko Konrad , Shanbhag Aakash D. , Singh Ananya , Hauser M. Timothy , Miller Robert J. H. , Liang Joanna X. , Motwani Manish , Kwieciński Jacek , Sharir Tali , Einstein Andrew J. , Fish Mathews B. , Ruddy Terrence D. , Kaufmann Philipp A. , Sinusas Albert J. , Miller Edward J. , Bateman Timothy M. , Dorbala Sharmila , Di Carli Marcelo , Berman Daniel S. , Dey Damini , Slomka Piotr J.
Published: May 2023

Standard clinical interpretation of myocardial perfusion imaging (MPI) has proven prognostic value for predicting major adverse cardiovascular events (MACE). However, personalizing predictions to a specific event type and time interval is more challenging. We demonstrate an explainable deep learning model that predicts the time-specific risk separately for all-cause death, acute coronary syndrome (ACS), and revascularization directly from MPI and 15 clinical features. We train and test the model internally using 10-fold hold-out cross-validation (n = 20,418) and externally validate it in three separate sites (n = 13,988) with MACE follow-ups for a median of 3.1 years (interquartile range [IQR]: 1.6, 3.6). We evaluate the model using the cumulative dynamic area under receiver operating curve (cAUC). The best model performance in the external cohort is observed for short-term prediction – in the first six months after the scan, mean cAUC for ACS and all-cause death reaches 0.76 (95% confidence interval [CI]: 0.75, 0.77) and 0.78 (95% CI: 0.78, 0.79), respectively. The model outperforms conventional perfusion abnormality measures at all time points for the prediction of death in both internal and external validations, with improvement increasing gradually over time. Individualized patient explanations are visualized using waterfall plots, which highlight the contribution degree and direction for each feature. This approach allows the derivation of individual event probability as a function of time as well as patient- and event-specific risk explanations that may help draw attention to modifiable risk factors. Such a method could help present post-scan risk assessments to the patient and foster shared decision-making.
Definitive Endodermal Cells Supply an in vitro Source of Mesenchymal Stem/Stromal Cells
Authors: Zhang Yumeng , Yi Ye , Xiao Xia , Hu Lingling , Xu Jiaqi , Zheng Dejin , Koc Ho Cheng , Chan Un In , Meng Ya , Lu Ligong , Liu Weiwei , Xu Xiaoling , Shao Ningyi , Cheung Edwin Chong Wing , Xu Ren-He , Chen Guokai
Published: May 2023

Mesenchymal stem/Stromal cells (MSCs) have great therapeutic potentials, and they have been isolated from various tissues and organs including definitive endoderm (DE) organs, such as the lung, liver and intestine. MSCs have been induced from human pluripotent stem cells (hPSCs) through multiple embryonic lineages, including the mesoderm, neural crest, and extraembryonic cells. However, it remains unclear whether hPSCs could give rise to MSCs in vitro through the endodermal lineage. Here, we report that hPSC-derived, SOX17+ definitive endoderm progenitors can further differentiate to cells expressing classic MSC markers, which we name definitive endoderm-derived MSCs (DE-MSCs). Single cell RNA sequencing demonstrates the stepwise emergence of DE-MSCs, while endoderm-specific gene expression can be elevated by signaling modulation. DE-MSCs display multipotency and immunomodulatory activity in vitro and possess therapeutic effects in a mouse ulcerative colitis model. This study reveals that, in addition to the other germ layers, the definitive endoderm can also contribute to MSCs and DE-MSCs could be a cell source for regenerative medicine.
Electrochemical CO2reduction towards formic acid and methanol on transition metal oxide surfaces as a function of CO coverage
Authors: Atrak Narges , Tayyebi Ebrahim , Skúlason Egill
Published: May 2023

Density functional theory is used to study the effect of varying CO coverage on transition metal oxide surfaces on the selectivity and activity of the CO2reduction reaction towards methanol and formic acid formation.
Atomic layer deposition of yttrium oxide as a protective coating for lithium metal anodes
Authors: Zhao Bo , Li Jin , Guillaume Maxime , Cremers Véronique , Henderick Lowie , Dendooven Jolien , Detavernier Christophe
Published: May 2023

ALD of a Y2O3 coating layer on Li metal anodes can effectively suppress Li dendrite growth, leading to a uniform plating–stripping process in Li metal batteries with more stable performance and prolonged lifespan.
Lower blood lipid level from the administration of plant tannins via altering the gut microbiota diversity and structure
Authors: Wang Xiaoqi , Hao Wenjing , Huang Xinyi , Duan Ziyuan
Published: May 2023

Twenty-four Tan sheep were randomly assigned into 4 groups to study the capability of tannin supplementation (0.5% in dietary DM) to lower blood lipid levels mediated through the gut microbiota.
Solid–liquid transition induced by rigidity disparity in a binary mixture of cell tissues
Authors: Li Jia-jian , He Yu-ling , Ai Bao-quan
Published: May 2023

The two-dimensional melting of a binary mixture of cell tissues is investigated under rigidity disparity. The phase diagrams show that the increase in rigidity disparity can induce a solid–liquid transition at both zero and finite temperatures.
Understanding radiation response and cell cycle variation in brain tumour cells using Raman spectroscopy
Authors: Hill Iona E. , Boyd Marie , Milligan Kirsty , Jenkins Cerys A. , Sorensen Annette , Jirasek Andrew , Graham Duncan , Faulds Karen
Published: May 2023

The use of Raman spectroscopy to determine the radiation response of human glioma cells and how this response differs depending on the cell's position in the cell cycle.
Disproportionation of Sn(ii){CH(SiMe3)2}2 to ˙Sn(iii){CH(SiMe3)2}3 and ˙Sn(i){CH(SiMe3)2}: characterization of the Sn(i) product
Authors: Mears Kristian L. , Ruiz Bronson , Nguyen Gia-Ann , Zou Wenxing , Fettinger James C. , Power Philip P.
Published: May 2023

Half a century since the photolytic disproportionation of Lappert's dialkyl stannylene SnR2, R = CH(SiMe3)2 (1) gave the persistent trivalent radical [˙SnR3], the characterization of the corresponding Sn(i) product, ˙SnR is now described.
Can an external electric field switch between ethylene formation and l-arginine hydroxylation in the ethylene forming enzyme?
Authors: Chaturvedi Shobhit S. , Jaber Sathik Rifayee Simahudeen Bathir , Ramanan Rajeev , Rankin Joel A. , Hu Jian , Hausinger Robert P. , Christov Christo Z.
Published: May 2023

Computational demonstration of applying an external electric field to modify the reaction ratio of ethylene-forming enzyme in favor of ethylene generation from 2OG.
Spatial analysis of CO2 hydrogenation to higher hydrocarbons over alkali-metal promoted iron(ii)oxalate-derived catalysts
Authors: Skrypnik Andrey S. , Lund Henrik , Yang Qingxin , Kondratenko Evgenii V.
Published: May 2023

The kind of alkali metal in ferrous oxalate dihydrate affect the concentration and spatial distribution of iron carbides formed in situ in CO2 hydrogenation. These structural changes impact the rate of CH4 formation from CO2 but not from CO.
Predicting ruthenium catalysed hydrogenation of esters using machine learning
Authors: Mishra Challenger , von Wolff Niklas , Tripathi Abhinav , Brodie Claire N. , Lawrence Neil D. , Ravuri Aditya , Brémond Éric , Preiss Annika , Kumar Amit
Published: May 2023

The report describes the application of machine learning tools to predict hydrogenation of esters using molecular catalysts based on ruthenium.
Cubane-type tungsten–iron–sulfur clusters with a nitrogen atom in the core: terminal ligand substitutions and redox behaviors
Authors: Zhang Hong-Ying , Qiu Shu-Juan , Yang Huan-Huan , Wang Meng-Ting , Yang Jie , Wang Han-Bin , Liu Nai-Hao , Chen Xu-Dong
Published: May 2023

Terminal ligand replacement in combination with core redox chemistry has been carried out based on a cluster comprising a [WFe3S3N] cubane core, raising the possibility of regulating the electrochemical properties of M–Fe–S clusters with core 2p atom(s).
Decarbonating layered double hydroxides using a carbonated salt solution
Authors: Min Luofu , Duan Jingying , Song Chuan , Chen Yanan , Zhang Wen , Wang Yuxin
Published: May 2023

Stable CO32− in layered double hydroxides (LDHs) was deintercalated using a carbonated NaCl solution. HCO3− exhibits lower affinity to LDHs and can be easily replaced by Cl−.
5-Heptadecylresorcinol alleviated high-fat diet induced obesity and insulin resistance by activating brown adipose tissue
Authors: Yang Zihui , Yang Siqi , Wang Ziyuan , Hao Yiming , Wang Zongwei , Wei Yulong , Ye Gaoqi , Liu Jie , Wang Jing
Published: May 2023

5-Heptadecylresorcinol (AR-C17) improved the metabolism and energy expenditure of BAT, exhibiting a protective effect on obesity and insulin resistance in high-fat fed obese mice.
Multidimensional controllable fabrication of tumor spheroids based on a microfluidic device
Authors: Hou Ying , Zheng Yajing , Zheng Xiaonan , Sun Yucheng , Yi Xizhen , Wu Zengnan , Lin Jin-Ming
Published: May 2023

A multidimensional controllable tumor spheroid fabrication method based on droplet microfluidics and cell membrane engineering technology.
Room-temperature stacking disorder in layered covalent-organic frameworks from machine-learning force fields
Authors: Huang Ju , Shin Seung-Jae , Tolborg Kasper , Ganose Alex M. , Krenzer Gabriel , Walsh Aron
Published: May 2023

Large-scale computer simulations of layered covalent-organic frameworks reveal temporal and spatial fluctuations that can be described as zigzag disorder.
Chitosan-coated ultrapure silicon nanoparticles produced by laser ablation: biomedical potential in nano-oncology as a tumor-targeting nanosystem
Authors: Baati Tarek , Chaabani Imen , Salek Abir , Njim Leila , Selmi Mouna , Al-Kattan Ahmed , Hosni Karim
Published: May 2023

Chitosan ultrapure silicon nanoparticles produced by femtosecond laser ablation exhibited an ideal biodistribution profile within tumor microenvironment promising their application in the nano-oncology field as tumor targeting system.
TheKspgap enabled precipitation transformation reactions from transition metal hydroxides to sulfides for alkali metal ion storage
Authors: Zhao Qianrui , Tang Zhiwen , Pan Yuede , Han Jingjing , Yang Jinbiao , Guo Yongqiang , Lai Xiangqian , Yang Zhewei , Li Gang
Published: May 2023

A rule that theKspvalues for the sulfides are significantly lower than those for the corresponding hydroxides for the elements in groups 9–12 is reported, along with the precipitation transformation reactions and the battery applications.
The expedient, CAET-assisted synthesis of dual-monoubiquitinated histone H3 enables evaluation of its interaction with DNMT1
Authors: Li Zichen , Tong Zebin , Gong Qingyue , Ai Huasong , Peng Shuai , Chen Cong , Chu Guo-Chao , Li Jia-Bin
Published: May 2023

The expedient chemical synthesis of dual-monoubiquitinated histone through the CAET-assisted strategy is presented.
Copper-catalyzed [1,3]-nitrogen rearrangement ofO-aryl ketoximesviaoxidative addition of N–O bond in inverse electron flow
Authors: Suzuki Mao , Terada Masahiro , Nakamura Itaru
Published: May 2023

[1,3]-Nitrogen rearrangement reactions ofO-aryl ketoximes was catalytically promoted by IPrCuBr and BF3·OEt2. The oxidative addition of the N–O bond to the Cu catalyst is accelerated by donation of electrons from both nitrogen and oxygen atoms.
Secondary interaction-manipulated metal–organic crystalline nanotube array for gas sensing
Authors: Hu Jieying , Xiao Jian-Ze , Liao Wei-Ming , Liu Shoujie , Li Jianming , He Yonghe , Yu Lin , Li Qiaohong , Xu Gang , He Jun
Published: May 2023

A semiconducting metal–organic crystalline nanotube array (MO-CNA) was constructed by the induction of Pb⋯S secondary interactions, exhibiting highly selective and sensitive NO2 sensing with a low limit of detection.
Elucidating the effect of Ag interlayer formation on the intrinsic mechanical properties of free-standing ITO/Ag/ITO thin films
Authors: Oh Seung Jin , Lee Sangmin , Choi Kyung Cheol , Kwon Jeong Hyun , Kim Taek-Soo
Published: May 2023

The impact of Ag interlayer formation governing the intrinsic mechanical behavior of ITO/Ag/ITO thin films is proposed, which can fundamentally contribute to the robust design of advanced flexible electronics.
First perihelion of EUI on the Solar Orbiter mission
Authors: Berghmans D. , Antolin P. , Auchère F. , Aznar Cuadrado R. , Barczynski K. , Chitta L. P. , Gissot S. , Harra L. , Huang Z. , Janvier M. , Kraaikamp E. , Long D. M. , Mandal S. , Mierla M. , Parenti S. , Peter H. , Rodriguez L. , Schühle U. , Smith P. J. , Solanki S. K. , Stegen K. , Teriaca L. , Verbeeck C. , West M. J. , Zhukov A. N. , Appourchaux T. , Aulanier G. , Buchlin E. , Delmotte F. , Gilles J. M. , Haberreiter M. , Halain J.-P. , Heerlein K. , Hochedez J.-F. , Gyo M. , Poedts S. , Renotte E. , Rochus P.
Published: May 2023

Context. The Extreme Ultraviolet Imager (EUI) on board Solar Orbiter consists of three telescopes: the two High Resolution Imagers, in EUV (HRIEUV) and in Lyman-α (HRILya), and the Full Sun Imager (FSI). Solar Orbiter/EUI started its Nominal Mission Phase on 2021 November 27.

Aims. Our aim is to present the EUI images from the largest scales in the extended corona off-limb down to the smallest features at the base of the corona and chromosphere. EUI is therefore a key instrument for the connection science that is at the heart of the Solar Orbiter mission science goals.

Methods. The highest resolution on the Sun is achieved when Solar Orbiter passes through the perihelion part of its orbit. On 2022 March 26, Solar Orbiter reached, for the first time, a distance to the Sun close to 0.3 au. No other coronal EUV imager has been this close to the Sun.

Results. We review the EUI data sets obtained during the period 2022 March–April, when Solar Orbiter quickly moved from alignment with the Earth (2022 March 6), to perihelion (2022 March 26), to quadrature with the Earth (2022 March 29). We highlight the first observational results in these unique data sets and we report on the in-flight instrument performance.

Conclusions. EUI has obtained the highest resolution images ever of the solar corona in the quiet Sun and polar coronal holes. Several active regions were imaged at unprecedented cadences and sequence durations. We identify in this paper a broad range of features that require deeper studies. Both FSI and HRIEUV operated at design specifications, but HRILya suffered from performance issues near perihelion. We conclude by emphasizing the EUI open data policy and encouraging further detailed analysis of the events highlighted in this paper.
A Bayesian model for human directional localization of broadband static sound sources
Authors: Barumerli Roberto , Majdak Piotr , Geronazzo Michele , Meijer David , Avanzini Federico , Baumgartner Robert
Published: May 2023

Humans estimate sound-source directions by combining prior beliefs with sensory evidence. Prior beliefs represent statistical knowledge about the environment, and the sensory evidence consists of auditory features such as interaural disparities and monaural spectral shapes. Models of directional sound localization often impose constraints on the contribution of these features to either the horizontal or vertical dimension. Instead, we propose a Bayesian model that flexibly incorporates each feature according to its spatial precision and integrates prior beliefs in the inference process. The model estimates the direction of a single, broadband, stationary sound source presented to a static human listener in an anechoic environment. We simplified interaural features to be broadband and compared two model variants, each considering a different type of monaural spectral features: magnitude profiles and gradient profiles. Both model variants were fitted to the baseline performance of five listeners and evaluated on the effects of localizing with non-individual head-related transfer functions (HRTFs) and sounds with rippled spectrum. We found that the variant equipped with spectral gradient profiles outperformed other localization models. The proposed model appears particularly useful for the evaluation of HRTFs and may serve as a basis for future extensions towards modeling dynamic listening conditions.
Research on Tangential Velocity Solution and Accuracy Analysis of Radar Target
Authors: Yin Qi , Sun Zepeng , Li Yangmeng , Hou Yujie
Published: May 2023

In this paper, a calculation method for the tangential velocity solution of radar target based on linear vector method is proposed. It makes full use of the advantage of high precision radial velocity measurement of radar, and realizes the accurate computation of tangential velocity of radar target. Based on the actual measurement capability of continuous wave (CW) radar, the accuracy of the tangential velocity is analyzed. The feasibility of calculation method and accuracy analysis method is verified by simulation experiment and measured data of shooting range.
Study on preparation and slow release properties of Magnesium-Al hydrotalcite with alanine intercalation
Authors: Feng Simin , Liu Qing , Wei Jing
Published: May 2023

The precursors of Mg-Al hydrotalcite (Mg/Al-LDHs-NO3) were prepared by low saturation coprecipitation method (constant pH method). In addition, alsine-intercalated magnesium-aluminum hydrotalcite (LDHs-Ala) was synthesized by low saturation coprecipitation (constant pH) and nucleation/crystallization isolation methods when the pH value was higher than the isoelectric point of alanine. The release properties of alanine intercalated hydrotalc in simulated gastric fluid (hydrochloric acid solution with pH=1.5) and intestinal fluid (phosphate solution with pH=7.4) were measured by spectrophotometer in vitro. The results showed that LDHs-Ala had good slow-release properties in simulated intestinal fluid and gastric fluid in vitro. Then sodium alginate was used to coated alanine intercalated hydrotalc for slow release in simulated intestinal fluid and simulated gastric fluid. It can be concluded that the coated intercalated hydrotalc has a low slow release rate in gastric fluid, but has a good slow release performance in simulated intestinal fluid. It can be concluded that the coated intercalated hydrotalc is expected to be a intestinal targeted release agent, which can be applied in biomedicine.
Recycling of detoxification wastewater from Semen Armeniacae Amarum
Authors: Liu Ke , Ren Yiyang , Li Yongsheng
Published: May 2023

Detoxification of Semen Armeniacae Amarum requires large amounts of water, and the detoxifying wastewater contains highly toxic hydrocyanic acid. This paper aims to explore the recovery of water after the removal of cyanide from it by chemical precipitation. The results show that when the dosage of ferrous sulfate is 1.76 times of the theoretical value, the cyanide removal in water can be reduced to about 2.70×105mol/L, the hydrocyanic acid in Semen Armeniacae Amarum can be entirely removed when the treated water is recycled.
Analysis and Discussion on Tension of Long Transport Belt
Authors: Mu Haojie
Published: May 2023

The technical field of belt tensioning force studied in this paper, in particular, relates to a hydraulic belt tensioning device, including a base, a hydraulic system and a rail fixed on the base, and a tail wheel trolley sliding on the rail; This device can provide a large tension to the tail wheel of the conveyor belt to meet the tension required by the long conveyor belt. At the same time, it can automatically adjust the tension to the tail wheel of the conveyor belt according to the tension of the conveyor belt to realize the dynamic tension control of the conveyor belt; The device prevents belt deviation and material leakage, reduces labor intensity of workers, avoids equipment accidents, and improves industrial production capacity.
Feasibility study of longitudinal transportation
Authors: Shu Zhejun , Mu Haojie
Published: May 2023

The research in this paper relates to the technical field of light load transportation, in particular to an electric upstairs car, which includes a frame, the top of the frame is fixedly equipped with a handle, the bottom of the frame is rotationally equipped with a group of wheels, the side wall near the bottom of the frame is fixedly equipped with a carrier plate, the support plate is fixedly arranged between the frames, and the box is fixedly arranged on the side of the support frame away from the carrier plate, A support rod is rotated on the opposite side of the box. The length of the support rod is larger than the diameter of the wheel. An arc surface is set on the support rod. A drive component is set in the box. The drive component is used to drive the support rod to rotate. This kind of electric car that can be transported longitudinally can reduce labor.
Comparisons of Design Schemes for the upper beam support at east cable tower of Lingdingyang Bridge on Shenzhen-Zhongshan Link
Authors: Yang Suhai , Zhao Jun , Li Zhen , Luo Lulu
Published: May 2023

The complex site conditions of Lingdingyang Bridge on Shenzhen-Zhongshan Link lead to many construction difficulties. The design of the support affects the construction quality of the super-height, large-weight and long-span beam on the cable tower. In order to achieve a high-standard construction and control the quality of the project, three support design schemes for the upper beam of the east cable tower of Lingdingyang Bridge were studied and compared by calculating and analyzing with the finite element software. Ultimately, the plan of the upper arch bracket stands out among the three schemes. The bracket scheme can not only meet the quality requirement of the main structure, but also reduce the construction difficulty and cost of the temporary structure, which can provide reference for the design of similar projects in the future.
Research on Modal Test for a Double-layered Stiffened Plate in Water
Authors: Wang Peng , Li Zhao , Chen Jiandong , Li Wei , Zhang Hao
Published: May 2023

Madal performance is the basic characteristics of structures, which will help to further understand the vibration of structures. Besides, fluid (e.g. water) coupled with structure will strongly affact the modal performance of structure. To get clear the modal performance, Modal tests are conducted for two-layered plate both in air and in water, and modal frequency and mode shape are given. With comparative analysis of modal frequencies in these two cases, it’s shown that influence of fluid on structural vibration is obvious, which will results in significantly reduction of modal frequency, and the maximum reduction is the second mode, and it is more than 42%. But it’s also noted that influence of fluid on mode shape is little.
La biocalcification bactérienne en milieu marin et ses applications
Authors: Vincent Julia , Colin Béatrice , Lanneluc Isabelle , Refait Philippe , Sabot René , Jeannin Marc , Sablé Sophie
Published: May 2023

La précipitation du carbonate de calcium (CaCO3) biologiquement induite en milieu marin joue un rôle important dans le cycle biogéochimique du carbone. Cette biocalcification est gouvernée par quatre facteurs clés : le taux de carbone inorganique dissous dont dépend le taux de carbonates (CO32−) dans le système, le taux d’ions calciques (Ca2+), le pH et la disponibilité des sites de nucléation c’est-à-dire des zones de cristallisation primaire de la phase solide du minéral. Les bactéries impliquées dans la biocalcification marine vont alors agir sur un ou plusieurs de ces facteurs. Ce processus naturel, qui se produit dans divers contextes géologiques, peut être imité afin de développer un certain nombre de technologies permettant la séquestration des métaux lourds, la protection des métaux contre la corrosion, la restauration et le renforcement de matériaux préexistants et la consolidation de matériaux granulaires. Cette étude passe en revue les différentes activités métaboliques microbiennes menant à la précipitation du CaCO3 ainsi que leurs applications potentielles en milieu marin.
Study on prediction and optimization of gas–solid erosion on S-Zorb reactor distribution plate
Authors: Ou Guofu , Huang Yuanxiang , Luo Minghao , Gu Youjie , Jin Haozhe
Published: May 2023

Adsorption desulfurization of catalytic gasoline (S Zorb) is an important desulfurization measure that is performed to meet the environmental protection requirements before the final product oil is sold in the market. The desulfurization reactor is a gas–solid two-phase flow environment composed of high-temperature and high-pressure hydrogen-oil mixed gas and sorbent particles; erosion prominently occurs on the reactor distribution plate. This study selects the typical gas–solid two-phase flow conditions and defines the erosion mechanism of the gas–solid two-phase flow environment for the plastic material of E347. Moreover, an S Zorb desulfurization reactor model is constructed, the CFD-DEM model is adopted to predict the wall erosion characteristics in a gas–solid two-phase flow environment, typical erosion laws are obtained via calculations. The erosion laws under the influence of variable parameters are studied based on the orthogonal test, the orthogonal test results show the best parameter combination, the parameter combination yields the maximum erosion rate and high erosion area that are 29.9% and 17.3%, respectively, lower than the existing values. Moreover, an optimum scheme of the inner structure parameters of the reactor is determined for reducing erosion rate and area.
Prognostic Role of Diastolic Left Ventricular Mechanical Dyssynchrony by Gated Single Photon Emission Computed Tomography Myocardial Perfusion Imaging in Post-Myocardial Infarction
Authors: Ha Le Ngoc , Trung Nguyen Thi Thanh , Son Mai Hong , Chien Do Van , Paeng Jin Chun
Published: May 2023

Objective This study is aimed to assess the prognostic value of diastolic left ventricular mechanical dyssynchrony (LVMD) measured by gated-single photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) in post-myocardial infarction (MI).

Subjects and Methods The study was conducted on 106 post-MI from January 2015 to January 2019. First, the indices of diastolic LVMD phase standard deviation (PSD) and histogram bandwidth (HBW) of post-MI were measured using the Cardiac Emory Toolbox. Subsequently, the post-MI patients were followed up, and the primary endpoint was major adverse cardiac events (MACEs). Finally, the prognostic value of dyssynchrony parameters for MACE was analyzed by the receiver-operating characteristics curve and survival analyses.

Results With the cut-off values of 55.5 degrees of PSD, the sensitivity and specificity in prediction of MACE were 75% and 80.8%, with the cut-off values of 174.5 degrees of HBW, the sensitivity and specificity were 75% and 83.3% respectively. There was a significant difference of time to MACE between groups of PSD less than 55.5 degrees and more than 55.5 degrees. PSD, HBW, and left ventricle ejection fraction (LVEF) assessed on GSPECT were significant factors in the prediction of MACE.

Conclusion Diastolic LVMD parameters of PSD and HBW derived from GSPECT are significant prognostic factors in predicting MACE in post-MI patients.
An Experimental Prospective Study on Effectiveness of Brief Heartfulness-Based Start ‘U’p Program on Anxiety and Perceived Stress in Allied Health Students
Authors: Philip Sanjana T. , Thimmapuram Jayaram , Gupta Himanshu , Fatima Tahreem Hussain , Rahate Subodh , Yeram Neelam , Thakur Kapil , Thakur Mansee
Published: May 2023

Aim and Objectives Health care education is an important issue in the development of countries. Stress and anxiety among health care students and workers are an area of increasing concern worldwide. Meditative practices have been shown to improve overall wellness. The aim of this study was to determine the efficacy and feasibility of a brief Heartfulness-Based Start ‘U’p program to reduce anxiety and perceived stress in allied health students of Mahatma Gandhi Mission School of Biomedical Sciences (MGMSBS), Mahatma Gandhi Mission Institute of Health Sciences (MGMIHS), Navi Mumbai, Maharashtra, India. The objective of this study was first to study the prevalence of anxiety and perceived stress in allied health students of MGMSBS, MGMIHS, Navi Mumbai, and then to study the effect of heartfulness meditation on measures of said emotional wellness.

Methods Seven sessions of Start ‘U’p Heartfulness Meditation of 2-hour duration once in every week was held over the course of 7 weeks. Two hundred and three participants enrolled for the heartfulness intervention. Changes in stress levels, anxiety levels, and mindfulness skills were assessed. Three self-reporting questionnaire tools—Beck Anxiety Inventory (BAI), Perceived Stress Scale (PSS), and Five Facet Mindfulness Questionnaire (FFMQ)—were used to determine the categorical scales (low, medium, and high) for anxiety and stress among students from baseline to post-intervention.

Results Our study revealed an improvement in anxiety and perceived stress post-intervention of brief Heartfulness-Based Start ‘U’p Program. Out of 203 students in this study, 75.86% were female and 24.14% were male. Students' BAI scores dropped an average of 2.91 points, whereas PSS scores dropped an average of 1.61 points. The largest increase in mindfulness was seen for nonjudging, with an average increase of 2.1 points (p ≤ 0.05) in categorical data from pre- to post-intervention based on the FFMQ tool.

Conclusion Our results indicate that heartfulness meditation practice offers an accessible and efficient method by which students' anxiety and stress can be improved. This may also improve their engagement in learning-oriented approaches and class activities.
Attitude and Perception of Dental Students and Dentists toward Efficacy of Typhodont Exercise Practiced as a Part of Preclinical Conservative Dentistry Curriculum for Routine Clinical Practice
Authors: Mulla Sayem Anwarhussain , Munshi Fatima Sajid , Patil Amit Hemraj , Mali Sheetal Dayaram , Saoji Hrishikesh Ashok , Jaiswal Himmat Chhedi
Published: May 2023

Objective Dentistry is a blend of both surgery and medicine. Cavity preparation in dentistry is a routine procedure used to remove defects or dental caries, which is irreversible and requires advanced skills. Preclinical training is done on typhodont, which are replicas of teeth that exhibit tooth morphology, as part of the dental curriculum. The aim of this study was to assess the attitude of dental professionals toward the efficacy of typhodont exercise in clinical practice.

Materials and Methods This study was a cross-sectional study conducted on dental professionals to understand the efficacy of typhodont exercise in clinical practice. The questionnaire consisted of 23 close-ended questions. The responses were coded as number/score (1–10). Responses were compiled on a MS Excel Worksheet and subjected to SPSS package. Chi-squared test and Mann–Whitney U test were used to analyze data.

Results A total of 250 responses were collected. About 72.8% participants stated that it helped them get oriented to the operating position. Regarding the preclinical exercises relevance to clinical exercise, a score of about 7 was obtained. However, the simulation of gingiva received a score of 5. Suggestions like integration of augmented reality (AR), virtual reality (VR), haptic technology along with extracted teeth as a conjunct to the typhodont exercise were received.

Conclusion This study suggested that preclinical typhodont exercises help the students in preparing for the upcoming clinical postings. However, the augmentation of typhodont exercise with AR, VR, haptic technology, and use of extracted teeth can furbish the current state of preclinical curriculum for conservative dentistry.
Surgical Site and Blood Stream Infections in Children with Delayed Sternal Closure after Cardiopulmonary Bypass Surgery: A Single-Center Experience
Authors: Hubara Evyatar , Serencev Irena , Kriger Or , Rachel Shatzman Steuerman , Keizman Eitan , Nellis Marianne E. , Mishali David , Lerner Reut Kassif , Katz Uriel , Skorchin Yelena , Barkai Galia , Pessach Itai
Published: May 2023

Objective Delayed sternal closure (DSC) is a frequent strategy for optimizing hemodynamics for patients after complicated cardiac surgery. However, this practice is associated with increased risk for infection and mortality. Despite the importance of antibiotic prophylaxis during open chest management, no clear recommendations are available. We sought to describe our practice with single-agent prophylactic antibiotic treatment for children with DSC.

Methods We retrospectively reviewed the electronic medical record of children with delayed chest closure after stage 1 palliative surgery, between January 2009 and December 2020. Demographics, antibiotic treatment, and data regarding postoperative infection occurrence were collected. The primary outcomes were surgical site infection (SSI) and blood stream infection (BSI) rates within 28 days of repair.

Results Sixty-eight patients were identified with single ventricle physiology, who underwent Damus–Kaye–Stansel or a modified Norwood procedure, remained with an open chest postoperatively, and were treated with prophylactic cefazolin. Sixty-three percent (43/68) of the children were male with a median (interquartile range) age of 9 (6–16) days. Eleven patients (16%) had an SSI or BSI identified postoperatively. Those with infections were significantly older (8 vs. 14 months, p = 0.037), had longer central line time (11 vs. 7 days, p = 0.004), had a central line location other than internal jugular (p = 0.022), and had a dialysis line (p = 0.022).

Conclusion Our study demonstrates a relatively low occurrence rate of postoperative SSIs and bacteremia with prophylactic cefazolin therapy among children with DSC suggesting that single-agent, narrow antimicrobial treatment may be sufficient in this high-risk population.
Epitaxial hexagonal boron nitride with high quantum efficiency
Authors: Laleyan David Arto , Lee Woncheol , Zhao Ying , Wu Yuanpeng , Wang Ping , Song Jun , Kioupakis Emmanouil , Mi Zetian
Published: May 2023

Two-dimensional (2D) hexagonal boron nitride (h-BN) is one of the few materials showing great promise for light emission in the far ultraviolet (UV)-C wavelength, which is more effective and safer in containing the transmission of microbial diseases than traditional UV light. In this report, we observed that h-BN, despite having an indirect energy bandgap, exhibits a remarkably high room-temperature quantum efficiency (∼60%), which is orders of magnitude higher than that of other indirect bandgap material, and is enabled by strong excitonic effects and efficient exciton-phonon interactions. This study offers a new approach for the design and development of far UV-C optoelectronic devices as well as quantum photonic devices employing 2D semiconductor active regions.
Non-phononic density of states of two-dimensional glasses revealed by random pinning
Authors: Shiraishi Kumpei , Mizuno Hideyuki , Ikeda Atsushi
Published: May 2023

The vibrational density of states of glasses is considerably different from that of crystals. In particular, there exist spatially localized vibrational modes in glasses. The density of states of these non-phononic modes has been observed to follow g(ω) ∝ ω4, where ω is the frequency. However, in two-dimensional systems, the abundance of phonons makes it difficult to accurately determine this non-phononic density of states because they are strongly coupled to non-phononic modes and yield strong system-size and preparation-protocol dependencies. In this article, we utilize the random pinning method to suppress phonons and disentangle their coupling with non-phononic modes and successfully calculate their density of states as g(ω) ∝ ω4. We also study their localization properties and confirm that low-frequency non-phononic modes in pinned systems are truly localized without far-field contributions. We finally discuss the excess density of states over the Debye value that results from the hybridization of phonons and non-phononic modes.
Revealing the hidden dynamics of confined water in acrylate polymers: Insights from hydrogen-bond lifetime analysis
Authors: Shikata Kokoro , Kikutsuji Takuma , Yasoshima Nobuhiro , Kim Kang , Matubayasi Nobuyuki
Published: May 2023

Polymers contain functional groups that participate in hydrogen bond (H-bond) with water molecules, establishing a robust H-bond network that influences bulk properties. This study utilized molecular dynamics (MD) simulations to examine the H-bonding dynamics of water molecules confined within three poly(meth)acrylates: poly(2-methoxyethyl acrylate) (PMEA), poly(2-hydroxyethyl methacrylate) (PHEMA), and poly(1-methoxymethyl acrylate) (PMC1A). Results showed that H-bonding dynamics significantly slowed as the water content decreased. Additionally, the diffusion of water molecules and its correlation with H-bond breakage were analyzed. Our findings suggest that when the H-bonds between water molecules and the methoxy oxygen of PMEA are disrupted, those water molecules persist in close proximity and do not diffuse on a picosecond time scale. In contrast, the water molecules H-bonded with the hydroxy oxygen of PHEMA and the methoxy oxygen of PMC1A diffuse concomitantly with the breakage of H-bonds. These results provide an in-depth understanding of the impact of polymer functional groups on H-bonding dynamics.
Heat and mass transfer analysis of constitutive model with autocatalytic chemical reaction within the Jeffery–Hamel flow perspective
Authors: Rehman Sohail , Hashim  , Alqahtani Sultan , Alshehery Sultan
Published: May 2023

This article examines the heat and mass transfer capabilities of a constitutive model in a thermally evolving steady laminar Jeffery–Hamel flow through a convergent-plate channel, including streamwise conduction with step changes in uniform wall temperature. A Jeffery–Hamel problem with a simple shear flow is used to undertake a comparative computational analysis of the thermal behavior of a viscoelastic fluid subjected to autocatalytic processes. The flow is tracked in a purely radial orientation with the deployment of coupled stresses in momentum conservation. The computational solutions for the flow, temperature and concentration distribution, and heat and mass transfer coefficient of a viscoelastic fluid obeying the complex Oldroyd-B constitutive equation in laminar converging channel flows are established. The analysis of the impacts of the thermal radiation, the heat source, and the chemical reaction as an autocatalytic process is included in the model, which is valid for fully developed thermal and hydrodynamic flow conditions with a constant heat and mass flux imposed at the wall. In the diverging part of the channel, where vortex compression is the predominant flow topology, there exist patches of local flow compression. On the flow field, the modified relaxation and retardation parameters show an opposing behavior. An Oldroyd-B fluid exhibits higher interactions with nearby vortices in the divergent channel, allowing a complex flow structure. The viscoelastic characteristics are anticipated to change the homogeneous–heterogeneous reaction transport processes, offering tremendous potential for applications in associated sectors. The deceleration flow in the diverging channel and the acceleration flow in the converging channel augment the average Nusselt numbers.
Corrigendum to: Assessing genetic diversity and population structure of Iranian melons (Cucumis melo) collection using primer pair markers in association with resistance to Fusarium wilt
Authors: Sadeghpour Neda , Asadi-Gharneh Hossein Ali , Nasr-Esfahani Mehdi , Khankahdani Hamed Hassanzadeh , Golabadi Maryam
Published: May 2023

We evaluated genetic diversity and population structure of Iranian melons (Cucumis melo L.) using combinations of 35 primer pairs: 15 Simple-Sequence-Repeats (SSR); 10 Inter-Simple-Sequence-Repeats (ISSR); and 10 Sequence-related amplified polymorphism (SRAP) markers in association with resistance to melon Fusarium wilt, caused by Fusarium oxysporum f. sp. melonis (FOM). Genetic similarity was determined by simple matching coefficient (SSM) and dendrogram by clustering-analysis with unweighted pair groups using arithmetic averages (UPGMA). By combining ISSR-SSR-SRAP markers, a high degree of variation among the melons was detected. The mean polymorphism information content (PIC), marker index (MI), effective-number of alleles (I), expected heterozygosity (H), and Nei’s gene diversity parameters were 0.392, 0.979, 1.350, 0.551 and 0.225, respectively. According to MI, PIC, I, H, and Nei indices evaluation, ISSR6, ISSR9, SRAP3, SRAP5, SSR3 and SSR6 had the best performance in genetic diversity of the related melons population. The 35 primers yielded a total of 264 bands, of which 142 showed polymorphism. Clustering of genotypes based on resistance to Fusarium wilt, and comparison with grouping on SSR, SRAP and ISSR marker revealed a significant compliance between disease severity and molecular marker dendrograms. Thus, increasing the number of molecular markers for genetic diversity provides a powerful tool for future agricultural and conservation tasks.
Drivers of colony failure in a vulnerable coastal seabird, the Australian Fairy Tern (Sternula nereis nereis)
Authors: Greenwell C. N. , Dunlop J. N.
Published: May 2023

Context Understanding breeding success and site threat profiles is critical to conservation planning, particularly for species of conservation concern. Regular surveillance is fundamental to observing spatiotemporal changes at breeding colonies. Still, it can be challenging for species with broadly distributed, unpredictable populations susceptible to various threats. In these cases, cooperative networks and citizen science programs offer an opportunity to support monitoring and conservation efforts. Aims This study aimed to assess the outcomes, threats and sources of breeding failure at Australian Fairy Tern (Sternula nereis nereis) colonies. Methods Through collaborative surveillance, this study identified the outcomes and threats at 77 monitored colonies over five breeding seasons between 2017/18 and 2021/22. The leading causes of nest failure were then considered against the Recovery Plan for the Australian Fairy Tern to understand how the observed threats compare with the identified risks in this plan. Key results Nearly half (48%) of all colonies failed, with predation (32%) and inundation (27%) being the biggest causes of failure. At least 10 native and four invasive/domestic species contributed to the mortality of eggs, chicks, and/or adults or complete colony failure. Disturbance, including off-road vehicles, was identified as a recurring threat, impacting at least 30% of colonies. Conclusions These identified threats have the potential to drive population-level effects and were consistent with those identified under the Recovery Plan. Implications This study highlights the importance of developing practical solutions, including habitat protection, the control of invasive species and education programs to safeguard colonies and boost breeding success.
Founder personality and entrepreneurial outcomes: A large-scale field study of technology startups
Authors: Freiberg Brandon , Matz Sandra C.
Published: May 2023

Technology startups play an essential role in the economy—with seven of the ten largest companies rooted in technology, and venture capital investments totaling approximately $300B annually. Yet, important startup outcomes (e.g., whether a startup raises venture capital or gets acquired) remain difficult to forecast—particularly during the early stages of venture formation. Here, we examine the impact of an essential, yet underexplored, factor that can be observed from the moment of startup creation: founder personality. We predict psychological traits from digital footprints to explore how founder personality is associated with critical startup milestones. Observing 10,541 founder–startup dyads, we provide large-scale, ecologically valid evidence that founder personality is associated with outcomes across all phases of a venture’s life (i.e., from raising the earliest funding round to exiting via acquisition or initial public offering). We find that openness and agreeableness are positively related to the likelihood of raising an initial round of funding (but unrelated to all subsequent conditional outcomes). Neuroticism is negatively related to all outcomes, highlighting the importance of founders’ resilience. Finally, conscientiousness is positively related to early-stage investment, but negatively related to exit conditional on funding. While prior work has painted conscientiousness as a major benefactor of performance, our findings highlight a potential boundary condition: The fast-moving world of technology startups affords founders with lower or moderate levels of conscientiousness a competitive advantage when it comes to monetizing their business via acquisition or IPO.
Morphopragmatic analysis of reduplication in Nigerian Pidgin (Naija)
Authors: Odiegwu Nancy Chiagolum , Romero-Trillo Jesús
Published: May 2023

Reduplication has a strong presence in creoles and expanded Pidgins. It has been studied for the several grammatical functions it performs in these languages. The present study is based on morphopragmatics theory, and explores reduplication in Nigerian Pidgin with the goal of identifying the pragmatic meanings it conveys. To achieve this, we analysed data from Wazobia FM, a Nigerian Pidgin-based radio station in Nigeria. The analysis process involved interviews and a focus group discussion with native informants. Our results show that in addition to more prototypical iconic meanings, some categories of reduplication in Nigerian Pidgin convey secondary meanings that are often heavily pragmatically and pejoratively charged, and which speakers strategically use to mark in-group and out-group associations, as well as to neutralize or attenuate the inherent negative meanings of the simplex forms.
An incomplete circle of alopecia: a new case of halo scalp ring?
Authors: Patrizi A , Savoia F , Neri I , Bardazzi F.
Published: May 2023

This article does not have an abstract.
Prepared to stop: how sense of agency in a preceding trial modulates inhibitory control in the current trial
Authors: Ren Qiaoyue , Kaiser Jakob , Gentsch Antje , Schütz-Bosbach Simone
Published: May 2023

Feeling in control of actions and events can enhance motivation for further actions. How this sense of agency (SoA) in fact influences flexible motor control remains poorly understood. Here, we investigated the effect of SoA on subsequent response inhibition in a modified go/no-go task with EEG recordings. We manipulated participants’ SoA by varying the presence, predictability, and emotional valence of a visual outcome for a given motor action. When participants unexpectedly did not receive any visible outcome following their action on trial n – 1, they exhibited slower responses and lower hit rates to the go signal but higher rates of successful inhibition to the no-go signal on trial n, regardless of the emotional valence of the expected action outcome. Furthermore, enhanced inhibitory tendencies were accompanied by reduced N2 and P3 amplitudes, midfrontal theta power, and theta synchronization between midfrontal and medial to parietal areas, indicating that less top-down control is required for successful response inhibition on trial n after experiencing low SoA on trial n – 1. These findings suggest that feeling less in control in a preceding trial makes it easier to implement inhibitory control in the current trial, thereby providing new insights into the role of SoA in goal-directed behavior.