bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 9 from Genetic Polymorphisms and Protein Expression of NRF2 and Sulfiredoxin Predict Survival Outcomes in Breast Cancer
Authors: Hartikainen Jaana M. , Tengström Maria , Kosma Veli-Matti , Kinnula Vuokko L. , Mannermaa Arto , Soini Ylermi
Published: March 2023

PDF file - 73K, Predicted functional effects of the studied SNPs in NRF2 and SRXN1 genes
Supplementary Figures from SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function
Authors: Chen Chun-Hau , Chang Che-Chang , Lee Tae Ho , Luo ManLi , Huang Pengyu , Liao Pei-Hsin , Wei Shuo , Li Fu-An , Chen Ruey-Hwa , Zhou Xiao Zhen , Shih Hsiu-Ming , Lu Kun Ping
Published: March 2023

Supplementary Figures - PDF file 635K, Supplementary Figure S1. Pin1 is modified on Lys6 and Lys63 by SUMO1 in vitro and in vivo. Supplementary Figure S2. Pin1 Lys6 and Lys63 mutations increase its ability to active cyclin D1 promoter and stabilize cyclin D1 protein in cells. Supplementary Figure S3. SENP1 binds Pin1 and thereby positively regulates cyclin D1 activation
Supplementary Figures 1-8 from β-Catenin/POU5F1/SOX2 Transcription Factor Complex Mediates IGF-I Receptor Signaling and Predicts Poor Prognosis in Lung Adenocarcinoma
Authors: Xu Chuan , Xie Dan , Yu Shi-Cang , Yang Xiao-Jun , He Li-Ru , Yang Jing , Ping Yi-Fang , Wang Bin , Yang Lang , Xu Sen-Lin , Cui Wei , Wang Qing-Liang , Fu Wen-Juan , Liu Qing , Qian Cheng , Cui You-Hong , Rich Jeremy N. , Kung Hsiang-Fu , Zhang Xia , Bian Xiu-Wu
Published: March 2023

Supplementary Figures 1-8 PDF file 1850K, Supplementary Figure 1. LACSLCs derived from A549 and H358 cell lines; Supplementary Figure 2. Sphere LACSLCs derived from A549 cell line expressed high levels of CSLCs transcription factors including SOX2 and POU5F1 with low expression of differentiated markers CK8/CK18;Supplementary Figure 3. Immunofluorescence staining of CD133 and ALDH1A1;Supplementary Figure 4. Correlation of IGF-1R and ALDH1A1 with poor DSS in LAC patients;Supplementary Figure 5. Insulin signaling/IGF pathway is highly correlated with expression genes in LACSLCs;Supplementary Figure 6. Disruption of IGF-1R signaling pathway inhibits the self-renewal and the tumorigenic potential of human LACSLCs;Supplementary Figure 7. MEK inhibitor PD98059 has no effect on POU5F1; Expression of IGF-1, �-catenin and POU5F1 in fresh LAC specimens and A549 LACSLCs
Supplementary Figure Legends 1-4 from RORα Suppresses Breast Tumor Invasion by Inducing SEMA3F Expression
Authors: Xiong Gaofeng , Wang Chi , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: March 2023

PDF file - 57K
Supplementary Figure 2 from RORα Suppresses Breast Tumor Invasion by Inducing SEMA3F Expression
Authors: Xiong Gaofeng , Wang Chi , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: March 2023

PDF file - 1.2MB
Supplementary Table 2 from Proteomic Portrait of Human Breast Cancer Progression Identifies Novel Prognostic Markers
Authors: Geiger Tamar , Madden Stephen F. , Gallagher William M. , Cox Juergen , Mann Matthias
Published: March 2023

XLS file - 30MB
Supplementary Table 5 from Extensive Promoter DNA Hypermethylation and Hypomethylation Is Associated with Aberrant MicroRNA Expression in Chronic Lymphocytic Leukemia
Authors: Baer Constance , Claus Rainer , Frenzel Lukas P. , Zucknick Manuela , Park Yoon Jung , Gu Lei , Weichenhan Dieter , Fischer Martina , Pallasch Christian Philipp , Herpel Esther , Rehli Michael , Byrd John C. , Wendtner Clemens-Martin , Plass Christoph
Published: March 2023

PDF file - 37K, Table S5 contains microRNA expression data obtained by the Illumina BeadChip system
Supplementary Figure 2 from Proteomic Portrait of Human Breast Cancer Progression Identifies Novel Prognostic Markers
Authors: Geiger Tamar , Madden Stephen F. , Gallagher William M. , Cox Juergen , Mann Matthias
Published: March 2023

PDF file - 145K
Supplementary Figure 1 from Proteomic Portrait of Human Breast Cancer Progression Identifies Novel Prognostic Markers
Authors: Geiger Tamar , Madden Stephen F. , Gallagher William M. , Cox Juergen , Mann Matthias
Published: March 2023

PDF file - 205K
Supplementary Methods from Extensive Promoter DNA Hypermethylation and Hypomethylation Is Associated with Aberrant MicroRNA Expression in Chronic Lymphocytic Leukemia
Authors: Baer Constance , Claus Rainer , Frenzel Lukas P. , Zucknick Manuela , Park Yoon Jung , Gu Lei , Weichenhan Dieter , Fischer Martina , Pallasch Christian Philipp , Herpel Esther , Rehli Michael , Byrd John C. , Wendtner Clemens-Martin , Plass Christoph
Published: March 2023

PDF file - 44K
Supplementary Figure 1 Legend from Unphosphorylated STAT1 Promotes Sarcoma Development through Repressing Expression of Fas and Bad and Conferring Apoptotic Resistance
Authors: Zimmerman Mary A. , Rahman Nur-Taz , Yang Dafeng , Lahat Guy , Lazar Alexander J. , Pollock Raphael E. , Lev Dina , Liu Kebin
Published: March 2023

PDF file - 54K
Supplementary Figure 11 from Neuropilin-1–Dependent Regulation of EGF-Receptor Signaling
Authors: Rizzolio Sabrina , Rabinowicz Noa , Rainero Elena , Lanzetti Letizia , Serini Guido , Norman Jim , Neufeld Gera , Tamagnone Luca
Published: March 2023

PDF file, 102K, Nrp1 expression is required for EGFR endocytosis independent of its tyrosine phosphorylation.
Supplementary Figure Legend from Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells
Authors: Shien Kazuhiko , Toyooka Shinichi , Yamamoto Hiromasa , Soh Junichi , Jida Masaru , Thu Kelsie L. , Hashida Shinsuke , Maki Yuho , Ichihara Eiki , Asano Hiroaki , Tsukuda Kazunori , Takigawa Nagio , Kiura Katsuyuki , Gazdar Adi F. , Lam Wan L. , Miyoshi Shinichiro
Published: March 2023

PDF file - 88K
Supplementary Figure 3 from Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy
Authors: Wong Christina S.F. , Sceneay Jaclyn , House Colin M. , Halse Heloise M. , Liu Mira C.P. , George Joshy , Hunnam Titaina C.U. Potdevin , Parker Belinda S. , Haviv Izhak , Ronai Ze'ev , Cullinane Carleen , Bowtell David D. , Möller Andreas
Published: March 2023

PDF file - 253K
Supplementary Figure 3 from Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells
Authors: Shien Kazuhiko , Toyooka Shinichi , Yamamoto Hiromasa , Soh Junichi , Jida Masaru , Thu Kelsie L. , Hashida Shinsuke , Maki Yuho , Ichihara Eiki , Asano Hiroaki , Tsukuda Kazunori , Takigawa Nagio , Kiura Katsuyuki , Gazdar Adi F. , Lam Wan L. , Miyoshi Shinichiro
Published: March 2023

PDF file - 115K, Phosho-receptor tyrosine kinase array and phosho-kinase array analyses of HCC827 parental and resistant lines.
Supplementary Figure 2 from Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy
Authors: Wong Christina S.F. , Sceneay Jaclyn , House Colin M. , Halse Heloise M. , Liu Mira C.P. , George Joshy , Hunnam Titaina C.U. Potdevin , Parker Belinda S. , Haviv Izhak , Ronai Ze'ev , Cullinane Carleen , Bowtell David D. , Möller Andreas
Published: March 2023

PDF file - 93K
Supplementary Figure 3 from Metronomic Dosing of BH3 Mimetic Small Molecule Yields Robust Antiangiogenic and Antitumor Effects
Authors: Imai Atsushi , Zeitlin Benjamin D. , Visioli Fernanda , Dong Zhihong , Zhang Zhaocheng , Krishnamurthy Sudha , Light Emily , Worden Frank , Wang Shaomeng , Nör Jacques E.
Published: March 2023

PDF file - 9.8K
Supplementary Table 2 from A Multistage Association Study Identifies a Breast Cancer Genetic Locus at NCOA7
Authors: Higginbotham Kathryn S.P. , Breyer Joan P. , Bradley Kevin M. , Schuyler Peggy A. , Plummer W. Dale , Freudenthal Marcia E. , Trentham-Dietz Amy , Newcomb Polly A. , Sanders Melinda E. , Page David L. , Parl Fritz F. , Egan Kathleen M. , Dupont William D. , Smith Jeffrey R.
Published: March 2023

Supplementary Table 2 from A Multistage Association Study Identifies a Breast Cancer Genetic Locus at NCOA7
Supplementary Figure 1 from HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair
Authors: Nowsheen Somaira , Cooper Tiffiny , Bonner James A. , LoBuglio Albert F. , Yang Eddy S.
Published: March 2023

PDF file - 26K, Lapatinib induces a homologous recombination repair defect in HER2+ breast cancer cell
Supplementary Figure Legends 1-6 from TNF-α Mediates Macrophage-Induced Bystander Effects through Netrin-1
Authors: Yang Yonghong , Wang Xingmin , Moore Danny R. , Lightfoot Stanley A. , Huycke Mark M.
Published: March 2023

PDF file - 108
Supplementary Figure 4 from TNF-α Mediates Macrophage-Induced Bystander Effects through Netrin-1
Authors: Yang Yonghong , Wang Xingmin , Moore Danny R. , Lightfoot Stanley A. , Huycke Mark M.
Published: March 2023

PDF file - 363K, showing Netrin-1 staining for 3 months biopsies
Supplementary Figure 5 from Cross-talk between HER2 and MED1 Regulates Tamoxifen Resistance of Human Breast Cancer Cells
Authors: Cui Jiajun , Germer Katherine , Wu Tianying , Wang Jiang , Luo Jia , Wang Shao-chun , Wang Qianben , Zhang Xiaoting
Published: March 2023

PDF file - 84K, ChIP-re-ChIP analyses of ERalpha and MED1 recruitments on the HER2 gene
Supplementary Figure 1 from Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors
Authors: Mitsiades Nicholas , Sung Clifford C. , Schultz Nikolaus , Danila Daniel C. , He Bin , Eedunuri Vijay Kumar , Fleisher Martin , Sander Chris , Sawyers Charles L. , Scher Howard I.
Published: March 2023

PDF file - 53K, Association of expression of transcripts involved in steroid synthesis and metabolism with AR transcriptional output in metastatic PCas
Supplementary Figure 1 from Oncolytic Virus and Anti–4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer
Authors: John Liza B. , Howland Linda J. , Flynn Jacqueline K. , West Alison C. , Devaud Christel , Duong Connie P. , Stewart Trina J. , Westwood Jenny A. , Guo Z. Sheng , Bartlett David L. , Smyth Mark J. , Kershaw Michael H. , Darcy Phillip K.
Published: March 2023

PDF file - 322K
Supplementary Video 4 from Basal but not Luminal Mammary Epithelial Cells Require PI3K/mTOR Signaling for Ras-Driven Overgrowth
Authors: Plichta Kristin A. , Mathers Jessica L. , Gestl Shelley A. , Glick Adam B. , Gunther Edward J.
Published: March 2023

MOV file - 1.7MB, Live cell imaging of H-RASG12V-driven luminal MEC overgrowth. Representative video depicting an organoid prepared from a Dox-naive luminalRas/GFP (MMTV-rtTA/TGFP/TRAS) mouse cultured in 3D with Dox
Supplementary Video 1 from Basal but not Luminal Mammary Epithelial Cells Require PI3K/mTOR Signaling for Ras-Driven Overgrowth
Authors: Plichta Kristin A. , Mathers Jessica L. , Gestl Shelley A. , Glick Adam B. , Gunther Edward J.
Published: March 2023

MOV file - 2MB, Live cell imaging of a K5-rtTA/TGFP organoid. Representative video depicting an organoid prepared from a Dox-na�ve basalGFP (K5-rtTA/TGFP) mouse cultured in 3D with Dox
Supplementary Figure Legend from β1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma
Authors: Carbonell W. Shawn , DeLay Michael , Jahangiri Arman , Park Catherine C. , Aghi Manish K.
Published: March 2023

PDF file - 63K
Supplementary Methods, Figures 1-2 from Regulation of ERBB2 Receptor by t-DARPP Mediates Trastuzumab Resistance in Human Esophageal Adenocarcinoma
Authors: Hong Jun , Katsha Ahmed , Lu Pengcheng , Shyr Yu , Belkhiri Abbes , El-Rifai Wael
Published: March 2023

PDF file - 215K, t-DARPP enhances ERBB2 expression on the cell surface Supplemental Figure 2. t-DARPP decreases binding of trastuzumab to ERBB2 receptor
Supplementary Figure 1, Tables 1-3 from Inactivation of the Dlc1 Gene Cooperates with Downregulation of p15INK4b and p16Ink4a, Leading to Neoplastic Transformation and Poor Prognosis in Human Cancer
Authors: Qian Xiaolan , Durkin Marian E. , Wang Dunrui , Tripathi Brajendra K. , Olson Lyra , Yang Xu-Yu , Vass William C. , Popescu Nicholas C. , Lowy Douglas R.
Published: March 2023

PDF file - 304K, Suppl. Table 1: Validated siRNAs used in the current studies Suppl. Fig. 1 Stress fiber formation in MEFs with or without v-Ras expression. Suppl. Fig. 2 The spontaneous transformation is reproducible using another Adeno-Cre treated MEF line (MEF-B) derived from a different embryo with conditional DLC1 knock-out. Suppl. Fig. 3 The complete sets of Kaplan-Meier Analyses from lung and colon cancers
Supplementary Table 2 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: March 2023

PDF file - 289K, Immunostaining of Pak1 and proliferative signaling markers in SCC
Supplementary Figure 1 from Targeting CD4+ T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell–Based Vaccination
Authors: Aarntzen Erik H.J.G. , De Vries I. Jolanda M. , Lesterhuis W. Joost , Schuurhuis Danita , Jacobs Joannes F.M. , Bol Kalijn , Schreibelt Gerty , Mus Roel , De Wilt Johannes H.W. , Haanen John B.A.G. , Schadendorf Dirk , Croockewit Alexandra , Blokx Willeke A.M. , Van Rossum Michelle M. , Kwok William W. , Adema Gosse J. , Punt Cornelis J.A. , Figdor Carl G.
Published: March 2023

PDF file - 51K, CONSORT flow chart
Supplementary Figure Legends 1-5, Table Legends 1-3 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: March 2023

PDF file - 131K
Supplementary Information from Rab25 Is a Tumor Suppressor Gene with Antiangiogenic and Anti-Invasive Activities in Esophageal Squamous Cell Carcinoma
Authors: Tong Man , Chan Kwok Wah , Bao Jessie Y.J. , Wong Kai Yau , Chen Jin-Na , Kwan Pak Shing , Tang Kwan Ho , Fu Li , Qin Yan-Ru , Lok Si , Guan Xin-Yuan , Ma Stephanie
Published: March 2023

PDF file, 153K, Supplementary Materials and Methods, Tables, Figure Legends, References
Supplementary Methods, Figures 1-9, Tables 2-6 from EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes β-Catenin–Dependent Hepatocarcinogenesis
Authors: Cheng Alfred S.L. , Lau Suki S. , Chen Yangchao , Kondo Yutaka , Li May S. , Feng Hai , Ching Arthur K. , Cheung Kin F. , Wong Hoi K. , Tong Joanna H. , Jin Hongchuan , Choy Kwong W. , Yu Jun , To Ka F. , Wong Nathalie , Huang Tim H.-M. , Sung Joseph J.Y.
Published: March 2023

Supplementary Methods, Figures 1-9, Tables 2-6 from EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes β-Catenin–Dependent Hepatocarcinogenesis
Supplementary Figures 1-5 from Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk
Authors: Brennan Kevin , Garcia-Closas Montserrat , Orr Nick , Fletcher Olivia , Jones Michael , Ashworth Alan , Swerdlow Anthony , Thorne Heather , Riboli Elio , Vineis Paolo , Dorronsoro Miren , Clavel-Chapelon Francoise , Panico Salvatore , Onland-Moret N. Charlotte , Trichopoulos Dimitrios , Kaaks Rudolf , Khaw Kay-Tee , Brown Robert , Flanagan James M.
Published: March 2023

PDF file - 207K
Supplementary Figure Legends 1-5, Tables 1-4 from Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk
Authors: Brennan Kevin , Garcia-Closas Montserrat , Orr Nick , Fletcher Olivia , Jones Michael , Ashworth Alan , Swerdlow Anthony , Thorne Heather , Riboli Elio , Vineis Paolo , Dorronsoro Miren , Clavel-Chapelon Francoise , Panico Salvatore , Onland-Moret N. Charlotte , Trichopoulos Dimitrios , Kaaks Rudolf , Khaw Kay-Tee , Brown Robert , Flanagan James M.
Published: March 2023

PDF file - 130K
Supplementary Table 1 from Hedgehog Signaling Blockade Delays Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein
Authors: Arzumanyan Alla , Sambandam Vaishnavi , Clayton Marcia M. , Choi Steve S. , Xie Guanhua , Diehl Anna Mae , Yu Dae-Yeul , Feitelson Mark A.
Published: March 2023

PDF file - 58K, qRT-PCR primers
Supplementary Tables 6 -7 from Dissection of T-cell Antigen Specificity in Human Melanoma
Authors: Andersen Rikke Sick , Thrue Charlotte Albæk , Junker Niels , Lyngaa Rikke , Donia Marco , Ellebæk Eva , Svane Inge Marie , Schumacher Ton N. , thor Straten Per , Hadrup Sine Reker
Published: March 2023

PDF file - 25K
Supplementary Figure 6 from Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation
Authors: Duhamel Stéphanie , Hébert Josée , Gaboury Louis , Bouchard Amélie , Simon Ronald , Sauter Guido , Basik Mark , Meloche Sylvain
Published: March 2023

PDF file - 828K
Supplementary Table 5 from Dissection of T-cell Antigen Specificity in Human Melanoma
Authors: Andersen Rikke Sick , Thrue Charlotte Albæk , Junker Niels , Lyngaa Rikke , Donia Marco , Ellebæk Eva , Svane Inge Marie , Schumacher Ton N. , thor Straten Per , Hadrup Sine Reker
Published: March 2023

XLS file - 41K
Supplementary Methods from Dissection of T-cell Antigen Specificity in Human Melanoma
Authors: Andersen Rikke Sick , Thrue Charlotte Albæk , Junker Niels , Lyngaa Rikke , Donia Marco , Ellebæk Eva , Svane Inge Marie , Schumacher Ton N. , thor Straten Per , Hadrup Sine Reker
Published: March 2023

PDF file - 94K
Supplementary Figure 4 from Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation
Authors: Duhamel Stéphanie , Hébert Josée , Gaboury Louis , Bouchard Amélie , Simon Ronald , Sauter Guido , Basik Mark , Meloche Sylvain
Published: March 2023

PDF file - 361K
Supplementary Figure Legends 1-3, Table Legends 1-7 from Dissection of T-cell Antigen Specificity in Human Melanoma
Authors: Andersen Rikke Sick , Thrue Charlotte Albæk , Junker Niels , Lyngaa Rikke , Donia Marco , Ellebæk Eva , Svane Inge Marie , Schumacher Ton N. , thor Straten Per , Hadrup Sine Reker
Published: March 2023

PDF file - 78K
Supplementary Figure 1 from 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
Authors: Liu Lucy , Nam Sangkil , Tian Yan , Yang Fan , Wu Jun , Wang Yan , Scuto Anna , Polychronopoulos Panos , Magiatis Prokopios , Skaltsounis Leandros , Jove Richard
Published: March 2023

Supplementary Figure 1 from 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
Supplementary Figure Legends 1-4 from Tumor-Derived Chemokine CCL5 Enhances TGF-β–Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells
Authors: Chang Li-Yuan , Lin Yung-Chang , Mahalingam Jayashri , Huang Ching-Tai , Chen Ten-Wen , Kang Chiao-Wen , Peng Hui-Min , Chu Yu-Yi , Chiang Jy-Ming , Dutta Avijit , Day Yuan-Ji , Chen Tse-Ching , Yeh Chau-Ting , Lin Chun-Yen
Published: March 2023

PDF file - 96K
Supplementary Figure 4 from Tumor-Derived Chemokine CCL5 Enhances TGF-β–Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells
Authors: Chang Li-Yuan , Lin Yung-Chang , Mahalingam Jayashri , Huang Ching-Tai , Chen Ten-Wen , Kang Chiao-Wen , Peng Hui-Min , Chu Yu-Yi , Chiang Jy-Ming , Dutta Avijit , Day Yuan-Ji , Chen Tse-Ching , Yeh Chau-Ting , Lin Chun-Yen
Published: March 2023

PDF file - 154K
Supplementary Methods, Figure Legends 1-6 from Densely Granulated Murine NK Cells Eradicate Large Solid Tumors
Authors: Liu Rebecca B. , Engels Boris , Arina Ainhoa , Schreiber Karin , Hyjek Elizabeth , Schietinger Andrea , Binder David C. , Butz Eric , Krausz Thomas , Rowley Donald A. , Jabri Bana , Schreiber Hans
Published: March 2023

PDF file - 114K
Supplementary Figure 3 from Tumor-Derived Chemokine CCL5 Enhances TGF-β–Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells
Authors: Chang Li-Yuan , Lin Yung-Chang , Mahalingam Jayashri , Huang Ching-Tai , Chen Ten-Wen , Kang Chiao-Wen , Peng Hui-Min , Chu Yu-Yi , Chiang Jy-Ming , Dutta Avijit , Day Yuan-Ji , Chen Tse-Ching , Yeh Chau-Ting , Lin Chun-Yen
Published: March 2023

PDF file - 119K
Supplementary Figure 1 from Tumor-Derived Chemokine CCL5 Enhances TGF-β–Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells
Authors: Chang Li-Yuan , Lin Yung-Chang , Mahalingam Jayashri , Huang Ching-Tai , Chen Ten-Wen , Kang Chiao-Wen , Peng Hui-Min , Chu Yu-Yi , Chiang Jy-Ming , Dutta Avijit , Day Yuan-Ji , Chen Tse-Ching , Yeh Chau-Ting , Lin Chun-Yen
Published: March 2023

PDF file - 106K
Supplementary Figure 3 from Densely Granulated Murine NK Cells Eradicate Large Solid Tumors
Authors: Liu Rebecca B. , Engels Boris , Arina Ainhoa , Schreiber Karin , Hyjek Elizabeth , Schietinger Andrea , Binder David C. , Butz Eric , Krausz Thomas , Rowley Donald A. , Jabri Bana , Schreiber Hans
Published: March 2023

PDF file - 323K
Supplementary Table 1 from Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma
Authors: Chan Isaac S. , Guy Cynthia D. , Chen Yuping , Lu Jiuyi , Swiderska-Syn Marzena , Michelotti Gregory A. , Karaca Gamze , Xie Guanhua , Krüger Leandi , Syn Wing-Kin , Anderson Blair R. , Pereira Thiago A. , Choi Steve S. , Baldwin Albert S. , Diehl Anna Mae
Published: March 2023

PDF file - 54K, Related primer sequences
Supplementary Methods , Figure Legends 1-5 from Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma
Authors: Chan Isaac S. , Guy Cynthia D. , Chen Yuping , Lu Jiuyi , Swiderska-Syn Marzena , Michelotti Gregory A. , Karaca Gamze , Xie Guanhua , Krüger Leandi , Syn Wing-Kin , Anderson Blair R. , Pereira Thiago A. , Choi Steve S. , Baldwin Albert S. , Diehl Anna Mae
Published: March 2023

PDF file - 82K
Supplementary Video 4 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: March 2023

MOV file - 3MB, Video for the mice receiving both flavopiridol and obatolcax (day 120 after tumor cell injection via tail vein)
Supplementary Video 3 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: March 2023

MOV file - 9.5MB, Video for the mice receiving obatolcax (day 120 after tumor cell injection via tail vein)
Supplementary Video 1 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: March 2023

MOV file - 2.5MB, Video for the mice receiving vehicle (day 80 after tumor cell injection via tail vein)
Supplementary Table 1 from The FGFR4-G388R Single-Nucleotide Polymorphism Alters Pancreatic Neuroendocrine Tumor Progression and Response to mTOR Inhibition Therapy
Authors: Serra Stefano , Zheng Lei , Hassan Manal , Phan Alexandria T. , Woodhouse Linda J. , Yao James C. , Ezzat Shereen , Asa Sylvia L.
Published: March 2023

PDF file,76K, Details of pNets studied
Supplementary Figures 2-6 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Authors: Laurent Julien , Hull Eveline Faes-van't , Touvrey Cedric , Kuonen François , Lan Qiang , Lorusso Girieca , Doucey Marie-Agnès , Ciarloni Laura , Imaizumi Natsuko , Alghisi Gian Carlo , Fagiani Ernesta , Zaman Khalil , Stupp Roger , Shibuya Masabumi , Delaloye Jean-François , Christofori Gerhard , Ruegg Curzio
Published: March 2023

Supplementary Figures 2-6 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Supplementary Figure Legends 1-9 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Authors: Laurent Julien , Hull Eveline Faes-van't , Touvrey Cedric , Kuonen François , Lan Qiang , Lorusso Girieca , Doucey Marie-Agnès , Ciarloni Laura , Imaizumi Natsuko , Alghisi Gian Carlo , Fagiani Ernesta , Zaman Khalil , Stupp Roger , Shibuya Masabumi , Delaloye Jean-François , Christofori Gerhard , Ruegg Curzio
Published: March 2023

Supplementary Figure Legends 1-9 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Supplementary Figure 9 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Authors: Laurent Julien , Hull Eveline Faes-van't , Touvrey Cedric , Kuonen François , Lan Qiang , Lorusso Girieca , Doucey Marie-Agnès , Ciarloni Laura , Imaizumi Natsuko , Alghisi Gian Carlo , Fagiani Ernesta , Zaman Khalil , Stupp Roger , Shibuya Masabumi , Delaloye Jean-François , Christofori Gerhard , Ruegg Curzio
Published: March 2023

Supplementary Figure 9 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Supplementary Table S3 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Authors: Permuth-Wey Jennifer , Kim Donghwa , Tsai Ya-Yu , Lin Hui-Yi , Chen Y. Ann , Barnholtz-Sloan Jill , Birrer Michael J. , Bloom Gregory , Chanock Stephen J. , Chen Zhihua , Cramer Daniel W. , Cunningham Julie M. , Dagne Getachew , Ebbert-Syfrett Judith , Fenstermacher David , Fridley Brooke L. , Garcia-Closas Montserrat , Gayther Simon A. , Ge William , Gentry-Maharaj Aleksandra , Gonzalez-Bosquet Jesus , Goode Ellen L. , Iversen Edwin , Jim Heather , Kong William , McLaughlin John , Menon Usha , Monteiro Alvaro N.A. , Narod Steven A. , Pharoah Paul D.P. , Phelan Catherine M. , Qu Xiaotao , Ramus Susan J. , Risch Harvey , Schildkraut Joellen M. , Song Honglin , Stockwell Heather , Sutphen Rebecca , Terry Kathryn L. , Tyrer Jonathan , Vierkant Robert A. , Wentzensen Nicolas , Lancaster Johnathan M. , Cheng Jin Q. , Sellers Thomas A.
Published: March 2023

Supplementary Table S3 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Supplementary Figure 2 from S-Glutathionylated Serine Proteinase Inhibitors as Plasma Biomarkers in Assessing Response to Redox-Modulating Drugs
Authors: Grek Christina L. , Townsend Danyelle M. , Uys Joachim D. , Manevich Yefim , Coker Woodrow J. , Pazoles Christopher J. , Tew Kenneth D.
Published: March 2023

PDF file - 5MB
Supplementary Figure 6 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: March 2023

PDF file - 857K, Primary CT-2 ALDH(high)-Wnt(low) tumor xenografts creates a phenocopy of an ALDH(high)-Wnt(high) tumor xenografts
Supplementary Figure 2 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: March 2023

PDF file, 323K, Secondary gliomas derived from GSCs.
Supplementary Figure 1 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: March 2023

PDF file, 167K, Establishment of mNSCs.
Supplementary Figure 2 from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Authors: Young Nathan P. , Crowley Denise , Jacks Tyler
Published: March 2023

Supplementary Figure 2 from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Supplementary Figures 1-4 from Lymphatic Reprogramming by Kaposi Sarcoma Herpes Virus Promotes the Oncogenic Activity of the Virus-Encoded G-protein–Coupled Receptor
Authors: Aguilar Berenice , Choi Inho , Choi Dongwon , Chung Hee Kyoung , Lee Sunju , Yoo Jaehyuk , Lee Yong Suk , Maeng Yong Sun , Lee Ha Neul , Park Eunkyung , Kim Kyu Eui , Kim Nam Yoon , Baik Jae Myung , Jung Jae U. , Koh Chester J. , Hong Young-Kwon
Published: March 2023

PDF file - 491K, Supplemental Figure 1. Absence of RGS4 expression in KS tumor cells. Supplemental Figure 2. Blood vessel-specific expression of RGS4. Supplemental Figure 3. Morphometric vascular analyses of control and RGS4-expressing tumors of similar sizes that were harvested at various time points from NSG mice. Supplemental Figure 4. Expression of blood- and lymphatic-signature genes in SVECs and derivative cells.
Supplementary Figures S1-S6 from PML-RARα and Its Phosphorylation Regulate PML Oligomerization and HIPK2 Stability
Authors: Shima Yutaka , Honma Yuki , Kitabayashi Issay
Published: March 2023

PDF file - 2380K, PML oligomerization is required for NB formation (S1); PML-RARa disrupts PML NBs (S2); PML-RARa 662-708 is required for the inhibition of PML NBs (S3); Interaction between PML IV and PML-RARa deletion and substitution mutants (S4); HIPK2 mRNA levels in the cells expressing HIPK2 and PML-RARa wild-type or point mutant at the third round of colonies (S5); Forskolin restores NBs in NB4 cells (S6)
Supplementary Figure 2 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: March 2023

PDF file - 138K, (A) Left. Purified C4-HD cells were cultured in chamber slides. After attachment, the medium was replaced and the cells starved in 1% chFCS for 24 h. Cells were untreated or treated with MPA (10 nM) and/or ICI (1 �M) during 6 h in the presence of BrdU and processed for immunofluorescence and confocal microscopy with specific antibodies: anti-BrdU (green) and cytokeratin (CK, red). Right. Quantification of BrdU+/CK+ cells (mean � SEM) after treatment. (B) Left. 3H-thymidine uptake assays: C4-HD cells were transfected with siRNAs for mouse ER� or a control siRNA, starved, treated for 48 h with MPA and the 3H-thymidine uptake index calculated as described previously. A representative experiment (mean � SEM) of three is shown. Right. Western blots: Protein extracts of C4-HD cells transfected for 48 h with siRNAs for mouse ER� as described previously were used to evaluate the expression of ER� (MC-20) in transfected cells. Erk1/2 was used as a loading control. Cell extracts from C4-HD cells treated with ICI for 24 hs were used as a control. (C) C4-HD cells were starved and then treated with ICI during 6, 12 and 24 h. ER� (MC-20) and PR (C-19) expression was analyzed by Western blot. �-actin (I-19, Santa Cruz) was used as a loading control.
Supplementary Table 1 from Aptamer Identification of Brain Tumor–Initiating Cells
Authors: Kim Youngmi , Wu Qiulian , Hamerlik Petra , Hitomi Masahiro , Sloan Andrew E. , Barnett Gene H. , Weil Robert J. , Leahy Patrick , Hjelmeland Anita B. , Rich Jeremy N.
Published: March 2023

PDF file - 42K, Aptamer Sequences.
Supplementary Figure 4 from Aptamer Identification of Brain Tumor–Initiating Cells
Authors: Kim Youngmi , Wu Qiulian , Hamerlik Petra , Hitomi Masahiro , Sloan Andrew E. , Barnett Gene H. , Weil Robert J. , Leahy Patrick , Hjelmeland Anita B. , Rich Jeremy N.
Published: March 2023

PDF file - 223K, Aptamer high tumor cells display preferential invasion.
Supplementary Methods, Figures 1-2, Tables 1-4 from Combinatorial Chemotherapeutic Efficacy in Non-Hodgkin Lymphoma Can Be Predicted by a Signaling Model of CD20 Pharmacodynamics
Authors: Harrold John M. , Straubinger Robert M. , Mager Donald E.
Published: March 2023

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Supplementary Figure 5 from TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells
Authors: Weiss Michele B. , Abel Ethan V. , Mayberry Melanie M. , Basile Kevin J. , Berger Adam C. , Aplin Andrew E.
Published: March 2023

PDF file - 1510K, TWIST1 is positively regulated by active ERK1/2 signaling in N-RAS mutant melanoma cells
Supplementary Figures from E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation
Authors: Zhi Xu , Zhao Dong , Wang Zehua , Zhou Zhongmei , Wang Chunyan , Chen Wenlin , Liu Rong , Chen Ceshi
Published: March 2023

Figure S1. RNF126 knockdown decreases cell viability in breast cancer cell lines Figure S2. The expression, subcellular localization, stability, and ubiquitination of RNF126 Figure S3. RNF126 knockdown increases p21 protein levels but does not change p21 mRNA levels in both MDA-MB-231 and PC-3 Figure S4. RNF126 knockdown delays the G1/S cell cycle progression in MDA-MB-231 Figure S5. Stable knockdown of RNF126 in SW527 suppresses cell growth in vitro and in vivo Figure S6. Negative expression correlation between RNF126 and p21 in breast cell lines Table S1: Primer sequences used in this study Table S2: siRNA and shRNA target sequences used in this study
Supplementary Figure Legends 1-2 from Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells
Authors: Noman Muhammad Zaeem , Buart Stéphanie , Romero Pedro , Ketari Sami , Janji Bassam , Mari Bernard , Mami-Chouaib Fathia , Chouaib Salem
Published: March 2023

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Supplementary Figure 4 from Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition
Authors: Kalev Peter , Simicek Michal , Vazquez Iria , Munck Sebastian , Chen Liping , Soin Thomas , Danda Natasha , Chen Wen , Sablina Anna
Published: March 2023

PDF file - 32K, Expression and LOH analysis of PPP2R2A in human cancer and cancer cell lines
Supplementary Figure 3 from Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition
Authors: Kalev Peter , Simicek Michal , Vazquez Iria , Munck Sebastian , Chen Liping , Soin Thomas , Danda Natasha , Chen Wen , Sablina Anna
Published: March 2023

PDF file - 33K, Suppression of PP2A regulatory subunits by specific shRNAs
Supplementary Figure 1 from Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition
Authors: Kalev Peter , Simicek Michal , Vazquez Iria , Munck Sebastian , Chen Liping , Soin Thomas , Danda Natasha , Chen Wen , Sablina Anna
Published: March 2023

PDF file - 104K, Automated image analysis of gammaH2AX immunostaining using In Cell Analyzer 2000
Supplementary Figures 1-14 from Autophagy Control by the VEGF-C/NRP-2 Axis in Cancer and Its Implication for Treatment Resistance
Authors: Stanton Marissa J. , Dutta Samikshan , Zhang Heyu , Polavaram Navatha S. , Leontovich Alexey A. , Hönscheid Pia , Sinicrope Frank A. , Tindall Donald J. , Muders Michael H. , Datta Kaustubh
Published: March 2023

PDF file - 1.6MB, Confocal microscopy and western blot results showing inhibition of autophagy and increase in chemotherapy-induced cancer cell death by specific inhibition of VEGF-C/NRP-2 axis
Supplementary Figure S1 from Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity
Authors: Ishii Nobuya , Harada Naoki , Joseph Eric W. , Ohara Kazuhiro , Miura Takaaki , Sakamoto Hiroshi , Matsuda Yutaka , Tomii Yasushi , Tachibana-Kondo Yukako , Iikura Hitoshi , Aoki Toshihiro , Shimma Nobuo , Arisawa Mikio , Sowa Yoshihiro , Poulikakos Poulikos I. , Rosen Neal , Aoki Yuko , Sakai Toshiyuki
Published: March 2023

Supplementary Figure S1 - PDF file 70K, Induction of p27Kip1 protein and cell cycle arrest by CH5126766
Supplementary Figure 7 from Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer
Authors: Wang Qingfei , Li Shau-Hsuan , Wang Hai , Xiao Yi , Sahin Ozgur , Brady Samuel W. , Li Ping , Ge Hailiang , Jaffee Elizabeth M. , Muller William J. , Hortobagyi Gabriel N. , Yu Dihua
Published: March 2023

PDF file - 37K, Anti-CTLA-4 mAb alone, anti-CTLA-4 mAb combined with HER2/Neu antibody only, or with TCN only showed no significant enhancement of antitumor effect
Supplementary Figure 6 from Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer
Authors: Wang Qingfei , Li Shau-Hsuan , Wang Hai , Xiao Yi , Sahin Ozgur , Brady Samuel W. , Li Ping , Ge Hailiang , Jaffee Elizabeth M. , Muller William J. , Hortobagyi Gabriel N. , Yu Dihua
Published: March 2023

PDF file - 137K, Depletion of CD8+ cells, CD4+ cells or both during HER2/Neu antibody and triciribine combination treatment
Supplementary Figure 5 from The SUMO E3-ligase PIAS1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA
Authors: Rabellino Andrea , Carter Brandon , Konstantinidou Georgia , Wu Shwu-Yuan , Rimessi Alessandro , Byers Lauren A. , Heymach John V. , Girard Luc , Chiang Cheng-Ming , Teruya-Feldstein Julie , Scaglioni Pier Paolo
Published: March 2023

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Supplementary Figure 5 from Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer
Authors: Wang Qingfei , Li Shau-Hsuan , Wang Hai , Xiao Yi , Sahin Ozgur , Brady Samuel W. , Li Ping , Ge Hailiang , Jaffee Elizabeth M. , Muller William J. , Hortobagyi Gabriel N. , Yu Dihua
Published: March 2023

PDF file - 36K, Evaluation of markers of other tumor-infiltrating immune cells
Supplementary Figure 1 from Ultrasound Increases Nanoparticle Delivery by Reducing Intratumoral Pressure and Increasing Transport in Epithelial and Epithelial–Mesenchymal Transition Tumors
Authors: Watson Katherine D. , Lai Chun-Yen , Qin Shengping , Kruse Dustin E. , Lin Yueh-Chen , Seo Jai Woong , Cardiff Robert D. , Mahakian Lisa M. , Beegle Julie , Ingham Elizabeth S. , Curry Fitz-Roy , Reed Rolf K. , Ferrara Katherine W.
Published: March 2023

PDF file - 51K, Representative biodistribution of tissues 48 hours after nanoparticle injection (N=8). Accumulation was significantly greater for insonified tumors (p<0.001).
Supplementary Figure Legend from Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence
Authors: Cui Hang , Kong Yahui , Xu Mei , Zhang Hong
Published: March 2023

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Supplementary Tables 1-4 from Defining NOTCH3 Target Genes in Ovarian Cancer
Authors: Chen Xu , Thiaville Michelle M. , Chen Li , Stoeck Alexander , Xuan Jianhua , Gao Min , Shih Ie-Ming , Wang Tian-Li
Published: March 2023

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Supplementary Figure 7 from Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence
Authors: Cui Hang , Kong Yahui , Xu Mei , Zhang Hong
Published: March 2023

PDF file - 38K, Data showing the correlation between Notch3 and p21 expression in human breast cancer and melanoma samples.
Supplementary Figure 5 from Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence
Authors: Cui Hang , Kong Yahui , Xu Mei , Zhang Hong
Published: March 2023

PDF file - 1009K, Data showing that the Notch signaling is required for Notch3-induced senescence and p21 expression in WS1 cells.
Supplementary Table 1 from MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer
Authors: Pakala Suresh B. , Rayala Suresh K. , Wang Rui-An , Ohshiro Kazufumi , Mudvari Prakriti , Reddy Sirigiri Divijendra Natha , Zheng Yi , Pires Ricardo , Casimiro Sandra , Pillai M. Radhakrishna , Costa Luis , Kumar Rakesh
Published: March 2023

PDF file - 21K, Primers used in RT-PCR and qPCR; Primers used for ChIP on mouse Stat3 promoter; Primers used of ChIP on mouse Twist1 promoter.
Supplementary Methods from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
Authors: Kovaleva Valentina , Mora Rodrigo , Park Yoon Jung , Plass Christoph , Chiramel Abhilash I. , Bartenschlager Ralf , Döhner Hartmut , Stilgenbauer Stephan , Pscherer Armin , Lichter Peter , Seiffert Martina
Published: March 2023

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Supplementary Figure 2 from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
Authors: Kovaleva Valentina , Mora Rodrigo , Park Yoon Jung , Plass Christoph , Chiramel Abhilash I. , Bartenschlager Ralf , Döhner Hartmut , Stilgenbauer Stephan , Pscherer Armin , Lichter Peter , Seiffert Martina
Published: March 2023

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Supplementary Figure 1 from Modulation of the ATPase and Transport Activities of Broad-Acting Multidrug Resistance Factor ABCC10 (MRP7)
Authors: Malofeeva Ekaterina V. , Domanitskaya Natalya , Gudima Mariya , Hopper-Borge Elizabeth A.
Published: March 2023

PDF file - 612K, Supplemental Figure 1. Detection of ABCC10 in membrane vesicle preparation and LLC-PK1 cell lines. A. Membrane vesicles prepared from High Five insect cells infected with ABCC10 or control baculovirus were resolved by SDS-PAGE and probed with polyclonal ABCC10 antibody. Full length ABCC10 is ~190 kDa. B. 30 �g of crude membranes prepared from LLC-PK1, LLC-ABCC10-11 and LLC-ABCC10-16 cells was analyzed by Western blot. The ABCC10 polyclonal antibody detected 2 bands with apparent Mr ~175,000-180,000 kDa and 213,000-218,000 kDa
Supplementary Figure Legend from Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma
Authors: Ostler Kelly R. , Yang Qiwei , Looney Timothy J. , Zhang Li , Vasanthakumar Aparna , Tian Yufeng , Kocherginsky Masha , Raimondi Stacey L. , DeMaio Jessica G. , Salwen Helen R. , Gu Song , Chlenski Alexandre , Naranjo Arlene , Gill Amy , Peddinti Radhika , Lahn Bruce T. , Cohn Susan L. , Godley Lucy A.
Published: March 2023

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Supplementary Figure 7 from Targeting Pioneering Factor and Hormone Receptor Cooperative Pathways to Suppress Tumor Progression
Authors: Shah Supriya , Prasad Shikha , Knudsen Karen E.
Published: March 2023

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Supplementary Figure 6 from Targeting Pioneering Factor and Hormone Receptor Cooperative Pathways to Suppress Tumor Progression
Authors: Shah Supriya , Prasad Shikha , Knudsen Karen E.
Published: March 2023

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Supplementary Figure 3 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
Authors: Patel Ronil A. , Forinash Kara D. , Pireddu Roberta , Sun Ying , Sun Nan , Martin Mathew P. , Schönbrunn Ernst , Lawrence Nicholas J. , Sebti Saïd M.
Published: March 2023

PDF file, 86K, RKI-1447 and RKI-1313 have little effect on cell cycle progression and apoptosis. (Panel A) MDA-MB-231 breast cancer cells were treated with either vehicle, RKI-1447 (10 μM) or RKI-1313 (10 μM) for 48 hours, fixed with 70% methanol overnight and stained with Propidium Iodide/Triton X-100. Cell cycle analysis was performed on BD Bioscience FACS Scan system as described below. (Panel B) MDA-MB-231 breast cancer cells were treated with either vehicle, RKI-1447 or RKI-1313 for 24 hours and processed for western immunoblotting with the indicated antibodies as described under Materials and Methods. Cell Cycle Analysis Method: MDA-MB-231 cells were plated in a 60mm dish and treated the next day with either vehicle, RKI- 1447 (10 �M) or RKI- 1313 (10 �M) for 48 hours. After incubation the cells were trypsinized and washed with cold PBS. The cells were resuspended in 0.5ml cold PBS and were fixed by adding 70% ethanol drop wise with gentle vortexing to obtain a single-cell suspension. Cells were left in the fixative overnight at 4{degree sign}C. The next day the cells were centrifuged and resuspended in 5ml PBS and washed. The cells were then incubated at room temperature for 1 hour in 1ml Propidium Iodide/Triton X-100 staining solution with RNase. After incubation, cell cycle analysis was performed on BD Bioscience FACS Scan system. The data was acquired and analyzed using BD CellQuest Pro software and ModFit, respectively.
Supplementary Figure 2 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
Authors: Patel Ronil A. , Forinash Kara D. , Pireddu Roberta , Sun Ying , Sun Nan , Martin Mathew P. , Schönbrunn Ernst , Lawrence Nicholas J. , Sebti Saïd M.
Published: March 2023

PDF file, 64K, Effect of RKI-1447 and RKI-1313 on anchorage dependent proliferation/survival of MDA-MB-231 cells. Cells were seeded in a 96-well plate and treated with increasing concentrations of RKI-1447 or RKI-1313. The effects of the compounds on cell viability under anchorage-dependent conditions were determined by MTT assay as described below. MTT Assay Method: MTT assay was performed exactly as described by us (see reference 41 in manuscript) to determine the effects of RKI-1447 on anchorage-dependent cell proliferation. Briefly, cells were plated in a 96 well tissue culture plate (1200 cells per well) and incubated for 24 hours. After incubation the cells were treated with vehicle or increasing concentrations of RKI-1447 or RKI-1313 for 72 hours. After incubation, freshly prepared MTT (2mg/ml) was added to each well and incubated for 3 hours. After incubation the plates were read at 540 nm.
Supplementary Figure 1 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
Authors: Patel Ronil A. , Forinash Kara D. , Pireddu Roberta , Sun Ying , Sun Nan , Martin Mathew P. , Schönbrunn Ernst , Lawrence Nicholas J. , Sebti Saïd M.
Published: March 2023

PDF file, 93K, RKI-1447 inhibits the phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human breast cancer cells. MDA-MB-231 and MDA-MB-468 breast cancer cells were treated with either vehicle or RKI-1447 for 1 hour and processed for western immunoblotting with the indicated antibodies as described under Materials and Methods.
Supplementary Figure Legends 1-3, Table Legend 1 from Plasmacytoid Dendritic Cells Promote Immunosuppression in Ovarian Cancer via ICOS Costimulation of Foxp3+ T-Regulatory Cells
Authors: Conrad Curdin , Gregorio Josh , Wang Yi-Hong , Ito Tomoki , Meller Stephan , Hanabuchi Shino , Anderson Sonya , Atkinson Neely , Ramirez Pedro T. , Liu Yong-Jun , Freedman Ralph , Gilliet Michel
Published: March 2023

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Supplementary Figure 1 from Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma
Authors: Suzuki Yoshiyuki , Mimura Kousaku , Yoshimoto Yuya , Watanabe Mitsuaki , Ohkubo Yu , Izawa Shinichirou , Murata Kazutoshi , Fujii Hideki , Nakano Takashi , Kono Koji
Published: March 2023

PDF file - 46K, Overall survival in the patients with (n=6, CTL(+)) and without antigen-specific T cell responses (n=10, CTL(-))
Supplementary Table 2C from Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
Authors: Satoh Hironori , Moriguchi Takashi , Takai Jun , Ebina Masahito , Yamamoto Masayuki
Published: March 2023

PDF file - 35K, High expression genes involved in lung tumor of Nrf2+/+ and Nrf2-/- mice.