bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Work-Life Balance, Happiness at Work, on Employee Performance
Authors: Bataineh Khaled adnan
Published: January 2019

The purpose of this research is to investigate the Relation of work-life balance, happiness, and employee performance, Accordingly, a questionnaire-based survey was designed to test the aforementioned model based on dataset of 289 employees’ from the ( Med Pharma), Pharmaceutical industries in Jordan, Multiple regression was conducted to examined the research hypotheses. The results indicated that work-life balance and happiness positively and significantly affect employee performance. However, job satisfaction non-impact in employee performance. The results have enormous implication for the Pharmaceutical industries sector in Jordan.
Beginning Preschool Teachers’ Views Toward Mentoring Programs in Turkey
Authors: Ali Özdemir , Cansu Kaygısız
Published: January 2019

The main purpose of this study is to reveal the view of preschool teachers who are in the first five years of the occupation about mentoring programs applied to them. To reveal the experiences and opinions of the teachers, the qualitative research design, phenomenology, was used. To determine the preschool teachers who are in the first 5 years of their occupation, criterion sampling from purposeful sampling methods was used. To achieve the purpose, the semi-structured interview form was applied to the teachers. The answers were analysed by using descriptive analysis approach. As a result, the teachers said that they have problems in communication and classroom management because both they are inexperienced and they are working with small age children. To overcome these problems, they develop their own ways mostly with trial and error. In addition, in the process of pre-service teachers’ education, they feel lonely. In the process, they do not take any help from any experienced teacher or any other helping resources. Also, they claim that the pre-service teacher trainings do not serve for the aim, and the process is just a formality. It is offered that teachers might be adapted to the profession with the help of special professional trainings and quality mentoring programs.
The Analysis of Test Anxiety Among Students at School of Physical Education and Sports in Terms of Demographic Variables
Authors: Caz Çağdaş , Çoban Oktay , Yıldırım Mehmet
Published: January 2019

The present study aims to measure levels of test anxiety among students studying at different departments at School of Physical Education and Sports. The population of the study consists of 780 students studying at different departments at School of Physical Education and Sports at Yozgat Bozok University during 2018–2019 academic year. The sample of the study consists of 382 students who study at different departments at School of Physical Education and Sports at Yozgat Bozok University during 2018–2019 academic year and voluntarily participated in the online survey sent them by e-mail. Survey was used as a method in the present study, and demographic variables were obtained using “personal information form”. “Westside test anxiety scale”, which was adapted to Turkish context and tested for reliability and validity by Totan and Yavuz (2009), was used to determine students’ level of test anxiety. The obtained data were statistically analyzed using SPSS 18 software program. Frequency analysis, percentage analysis, arithmetic means, t test and ANOVA analysis were used for data analysis. The analyses demonsrate that no statistically significant differences were observed among students’ levels of test anxiety in terms of four different variables (p>0.05). However, as for mean scores, it was found out that female students’ level of test anxiety was higher compared to male students. Students studying coaching education had a higher of test anxiety compared to those studying physical education and sports teaching and sports management. In addition, students who did not take notes during lessons had a higher level of test anxiety compared to those who took notes during lessons. Finally, students who reviewed lessons shortly before the test had a higher level of test anxiety compared to those who reviewed their lessons on a daily basis.
Metaphors on the Concepts of “Reading” and “Listening” Created by the Secondary School Students
Authors: Dincel Betul Keray
Published: January 2019

This research aims to examine the metaphors on the concepts of reading and listening of the secondary school students and is based on phenomenology. 390 randomly selected secondary school students participated in this study in the 2016–2017 academic year in Turkey. The study includes all the grades (5, 6, 7, & 8th) at the secondary school level. “Reading is like ..................., because .....................”, “Listening is like ..............., because ..................” were the two sentences given to the students and they were asked to fill in the blanks. The data were analyzed by the content analysis. The students created 385 metaphors about the concept of reading and 329 metaphors about the concept of listening. Metaphors on the concept of reading were divided into 11 categories: A source of knowledge/learning, development, necessity, imagination, life, finding peace, sincerity, boredom/suffocation, eternity, guidance, enjoyment. Metaphors on the concept of listening were divided into 9 categories: A source of knowledge/learning, necessity, imagination, life, finding peace, communication, boredom, guidance, enjoyment. In this research, metaphors were used to reveal the thoughts of secondary school students on the concepts of reading and listening.
A Cyber-Physical System
for Surface Roughness Monitoring in End-Milling
Authors: Župerl Uroš , Čuš Franci
Published: January 2019

A cyber-psychical machining system (CPMS) is developed to realize smart end-milling process monitoring. The CPMS provides a novel way for controlling the cutting chip size and monitoring the surface roughness in milling processes through Internet of Things (IoT) applications. The two level CPMS is realized by linking the IoT machining platform for process control to the machine tool with integrated visual system (VS). The VS is employed to acquire the signals of the cutting chip size during the machining of difficult to cut materials. The machining platform performs instant chip size and surface roughness control based on advanced signal processing, edge computing, modeling and cognitive corrective process control acting. A cognitive neural control system (CNCS) is employed to control the chip size by modifying the machining parameters and consequently maintaining surface roughness constant. An adaptive neural inference system (ANFIS) is applied to precisely model and in-process predict the surface roughness. Machining tests conducted using the proposed CPMS indicate that the cutting chip size and consequently the produced surface roughness are well maintained when the cutting-depth profile of a workpiece is varying step-wise or continuously.
Wool Economy During the European Bronze Age
Authors: Sabatini Serena
Published: January 2019

A number of studies over the last decades have considerably increased our knowledge about production and trade of woollen textiles during the Bronze Age in the Near East, the Aegean, and continental Europe. In the wider Mediterranean area, thanks to the abundance of available evidence, it has been possible to use the concept of wool economy as a frame of reference to define the complex mechanisms behind production and trade of wool. The main aim of this paper is to reflect upon using the concept of wool economy to enhance our understanding of the relevant archaeological evidence from Bronze Age continental Europe.
Innovative or Traditional? Diachronic Approach to Weaving Technology in Bronze Age Greece
Authors: Ulanowska Agata
Published: January 2019

This paper aims at recognising potential innovations in weaving technology that may have occurred in Bronze Age Greece. It discusses whether these assumed developments may be examined diachronically. This discussion is based on archaeological evidence of textile implements, such as loom weights and presumed traces of warp-weighted looms, as well as knowledge of traditional craft and experimental archaeology. After a short introduction discussing how technical innovations could possibly be recognised in weaving, the paper explores possible changes in the construction and functionality of the warp-weighted loom and potential uses of other types of looms in Greece. A distribution pattern of specific forms of a loom weight, e.g. discoid loom weights in particular, is examined as an innovation responding to the demand for fabrics of specific technical qualities and appearance, possibly associated with a spread of new weaving techniques which accompanied the transmission of these tools. Social relations and modes of organisation of textile production are considered factors that must have had a significant impact on creativity and innovativeness in weaving technology. However, the final conclusion is that specific relations between the organisation of weaving and the occurrence of innovative processes cannot be clearly recognised based on the available evidence.
The National Map of Security Threats as a tool to monitor security and public order
Authors: Kaduszkiewicz Marcin
Published: January 2019

Threats to public order compromise the personal security of the individual, forcing him to take action to improve it, and thus to guarantee it to the closest people. The right to ensure the security of the individual, society is one of the duties of a state whose omission can be considered a violation of human rights. By implementing this obligation, a threat monitoring system was created in Poland – the National Safety Threat Map. It is a tool used by the Police which in 2016 was initially piloted, then already throughout the country introduced this mechanism to monitor and counteract local threats, affecting the safety of residents. This tool uses the Internet as a source of information about threats from citizens. The instruction was issued for both users – citizens, as well as for policemen of users and local administrators, and instructions for proper and reliable implementation. They impose on the Police officers’ specific tasks in the system for the implementation of applications. The work is an attempt to answer the question: What tool is KMZB in the system of monitoring by the state of public security and order?

National Map of Security Threats (KMZB) – functions of the National Map of Security Threats in shaping local community safety, constitutes an element of the process of managing the public safety, as well as inspiring the local community in this respect. The Police as the formation serving the society and opened for its needs implemented the additional channel of the information exchange about the most troublesome threats defined on the local level.
ORGANISATIONS RESPONSIBLE FOR PUBLIC SAFETY AND ORDER ON WATER AND NEARBY AREAS
Authors: Łachut Marek
Published: January 2019

This article presents the functions of institutions and organizations operating on water and nearby areas. The purpose of this work is to show their role in improvement of water safety. The article attempts to systemize and enrich knowledge about functions of national institutions and non-government organizations that support the water rescue system in Poland.
DIFFERENT FACES OF SECURITY PERCEPTIONS
OF THE HUMAN SECURITY CONCEPT
Authors: Sypiański Waldemar
Published: January 2019

The perception of safety is a very individual feeling although it is the standard and the level of living that undoubtedly affect various fears and threats appearing in rich and poor societies. The aim of this article is to compare attitudes towards safety and its perception by people living aside, but in completely different social and economic conditions. Both South and North Koreas are historically very close to each other yet, totally different conditions of living on both sides of the Korean Peninsula make safety quite opposite notions. The residents of the Brasilian districts of poverty and crime, infamous favelas, live in a world where being a member of a gang ensures safety. For other inhabitants of Brasil and tourists, security means staying as far away as possible from favelados i.e., the residents of poor districts. For determined African refugees, Europe seems to be a safety heaven and even the risk of losing their lives on the long and most dangerous route to Europe is worth taking. However, for many Europeans their safety ends with the influx of immigrants.
A LIBERAL VISION OF SECURITY – AN ATTEMPT TO SYSTEMATIZE CONCEPTIONS
Authors: Urbanek Andrzej
Published: January 2019

In the article, its author attempted to systematize various concepts and approaches to the issue of security by representatives of political liberalism. Political liberalism now sets the main directions of thinking about security in Europe and the United States. Expanding the subjective scope of security, it undoubtedly contributed to the development of various security concepts in which not only the state but other entities become important actors in the international security environment. The article presents the main assumptions of a liberal vision of security, the approach to security by representatives of traditional liberalism and current trends.
Teacher planning in a learning outcome perspective: A multiple case study of mathematics and L1 Danish teachers
Authors: Bremholm Jesper , Skott Charlotte Krog
Published: January 2019

AbstractLike most European countries, Danish education is facing a radical shift towards a focus on learning outcomes, which calls for renewed attention to teachers’ instructional planning. In this article, we explore teacher planning in mathematics and L1 Danish, focussing particularly on the role of instructional materials. Using data from a lesson study project and a theoretical framework that conceptualises planning in a local institutional setting, we analyse planning at both teacher and school level. This allows us to identify practices in teachers’ planning that may hinder an outcome perspective, but that nevertheless seem meaningful in a broader institutional context.Keywords: Teacher planning, learning outcome, mathematics education, Danish as L1 education.Læreres planlægningspraksis i et læringsmålsperspektiv: Et multipelt casestudie af matematik- og dansklærereSammendragDanmark står, som mange europæiske lande, over for radikale uddannelsesforandringer med læringsmål som omdrejningspunkt, som kræver fornyet opmærksomhed på læreres undervisningsplanlægning. I artiklen udforsker vi læreres planlægningspraksis i matematik og dansk ved primært at fokusere på den rolle, som undervisningsmaterialer spiller. Ud fra data fra et lektionsstudieprojekt og en teoretisk ramme, der begrebsliggør planlægning i en lokal institutionel kontekst, analyserer vi planlægningspraksis ift. både et lærer- og et skoleniveau. Dette gør det muligt at identificere praksisser, der forhindrer lærere i at planlægge med fokus på læringsmål, men som ikke desto mindre forekommer meningsfulde, når de forstås i en bredere institutionel kontekstNøgleord: Læreres planlægning, læringsmål, matematikundervisning, danskundervisning (L1)
Virtual Worlds as Philosophical Tools: How to Philosophize with a Digital Hammer by Stefano Gualeni
Authors: Arjoranta Jonne
Published: January 2019

Book review of Stefano Gualeni. Virtual Worlds as Philosophical Tools: How to Philosophize with a Digital Hammer, Palgrave Macmillan,2015, 194 pp., USD 64.65, ISBN 1137521775
Carnal Hermeneutics and the Digital Game
Authors: Martin Paul
Published: January 2019

Carnal hermeneutics claims that the body makes sense of the world by making distinctions and evaluating those distinctions in a non-predicative mode. This article makes the case that ludohermeneutics can be enriched by attending to the way in which the body makes sense of digital games and advances carnal hermeneutics as a way of theorising this process. The article introduces carnal hermeneutics, argues for its relevance to ludo-hermeneutics, and outlines three examples of how carnal hermeneutics can be used to theorise sense-making in digital games. The first example demonstrates the capacity for touch-screen games to put us in a new relationship with the image. The second example shows how generic control schemas can take on new meanings in different games. The third example shows how marketing of game controllers draws on conventional attitudes to touch to make digital game touch meaningful.
Broad-Spectrum Bioactivity of Chitosan N-acetylglucosaminohydrolase (Chitosan NAGH) Extracted from Bacillus ligniniphilus
Authors: Akeel Raid Al , Hetta Helal F , Muslim Sahira Nsayef , Al-Kadmy Israa M S , Aziz Sarah Naji
Published: January 2019

Background: The genus Bacillus has species with strains that produce Chitosan N-acetylglucosaminohydrolase (NAGH), a hydrolytic enzyme. Objective: A novel bacterium, Bacillus ligniniphilus, was characterized as producing Chitosan NAGH. This study further examine its antibiofilm properties and its possible uses against biofilm-producing bacteria. Methods: Various sea soil samples were evaluated for the presence of Chitosan NAGH. The chosen isolate, Bacillus ligniniphilus 61, was then used to extract and purify Chitosan NAGH using precipitation in ammonium sulfate followed by polyethylene glycol–treated dialysis and gel-permeation chromatography. Biofilm inhibition and antimicrobial activity of Chitosan NAGH was estimated against different bacterial species. Both gene expression profiling of biofilm-related genes and an extracellular polymeric substance (EPS) inhibition assay were performed. Results: The BL61 strain was able to produce much more Chitosan activity than the other strains, as the latter only exhibited antimicrobial activity at low concentration levels; however, they did show as antibiofilm agents at varying proportions. Chitosan NAGH caused a uniform decrease in EPS formation in each isolate. Many biofilm-related genes, e.g., IcaABCD, decreased, but genes related to autoinducer synthetase were not affected by Chitosan NAGH. EPS, which is responsible for polysaccharide formation, was underexpressed at 3-fold down. Conclusions: The current study results allow future researchers to look for better and newer compounds with the antibiofilm property that inhibits the formation of biofilm created by a wide range of bacteria without affecting their growth.
Quadrados mágicos: um passeio pela História e pela Álgebra Linear
Authors: Melo Marcelo Ferreira de , Machado José Samuel
Published: January 2019

The objective of this work is to study the magic squares, to address historical aspects related to their emergence and their use by artists throughout the centuries, as well as to analyze the magic squares in the resolution of linear systems and in the language of the vector spaces of matrices. As a result, one can obtain another motivation for the study of matrices and linear systems, both in High School and Higher Education.
Water’s quality and environmental conditions of the hydric resources in Grajaú-MA
Authors: Machado Ferreira Fernando , Moreira Gleidiany Da Costa , Gomes de Sousa Silva Maria Elizabete , Santos Silva Ana Maria Kellen , Da Costa Moreira Gardjany , Rocha Jefferson De Almeida , Gomes Passos Ionara Nayana
Published: January 2019

Water is the essential element to develop and maintaining life, that is why the adoption of means of conservation of this essential resource is necessary. In Brazil, the ordinance No. 2914, from December 12th, 2011, of the Ministry Of Health establishes microbiological parameters, which determinate its quality, verifying its potability in order not to offer health risks. The research analyzed five samples from two different wells, placed in the same district of Grajaú-MA. The physical-chemical conditions were analyzed by the following parameters: total alkalinity, chlorides, total hardness, pH, iron, ammonia, chlorine, oxygen consumed, water turbidity by quick tests with the potability kit ALFAKIT and the microbiological conditions by the methodology of the multiple tubes based on the most probable number (MPN), besides seedlings on selective culture means. The results obtained in this research show that the samples of groundwater from five analyzed spots do not match the legislation, because they do not fit to the potability standards. This way, new analysis must be made, mainly microbiological and biochemical tests, to, this time on, adopt means that allow a proper treatment to this water that is used by the local communities.
Phytochemical and phytotoxic investigation of the aqueous leaf extract of Eugenia dysenterica DC. under laboratory conditions
Authors: Malheiros Rafael Pozzi , Mapeli Ana , Machado Luciana
Published: January 2019

The objective of this study was to carry out a phytochemical characterization of the aqueous leaf extract of Eugenia dysenterica DC., as well as to evaluate its phytotoxic potential on the germination and growth of Lactuca sativa L. and Zea mays L. under laboratory conditions. Concentrations of 250, 500, 1000, 2000 and 4000 mg/L of the extract in addition to the control were used for the bioassays. Under laboratory conditions this extract inhibited average growth of the radicle/primary root and hypocotyl/coleoptile leaves of lettuce and maize, with proportionality between the effect and the concentration being observed. The presence of phenols, hydrolysable tannins, flavonols, flavanones, flavanonols, xanthones, flavones, free steroids and saponins were identifiedin the aqueous extract. The aqueous extract of the plant species under study has a phytotoxic effect, and this effect is due to the presence of phenolic compounds, tannins, flavonoids and saponins.
La educación en la sociedad tradicional: padres, hijos y maestros en el epistolario El Secretario
Authors: Díaz Balado Alicia
Published: January 2019

Los epistolarios han constituido manuales de correspondencia para la difusión de las normas de la escritura epistolar. A partir de una breve presentación del epistolario El Secretario y del uso de la carta en el ámbito educativo, se analiza su contenido, centrado en la relación entre el maestro y el alumno, en la profesionalización del magisterio o en la renovación pedagógica. Los dos modelos de cartas seleccionados en el presente epistolario, A un estudiantillo y Contestación del estudiantillo, dan cuenta de las relaciones paterno-filiales ―focalizadas en un modelo de correspondencia característico del siglo XIX― al tiempo que permiten un análisis fundamentalmente pedagógico. Dicho análisis posibilita la observación sobre el significado del par maestro-discípulo, las influencias pedagógicas renovadoras, así como la función de la carta como medio de expresión infantil y de control paterno en la distancia paterno-filial.
Antón Alonso Ríos (1887-1980): Emigración, filantropía, republicanismo, represión y exilio de un maestro rural
Authors: Malheiro Gutiérrez Xosé M.
Published: January 2019

El presente texto reconstruye el perfil biográfico de un profesor gallego y líder político, Antón Alonso Ríos, teniendo en cuenta cinco aspectos que señalan, a su vez, sucesivas etapas en su trayectoria vital: la primera, como emigrante en la Argentina, marcada por su liderazgo entre una parte importante de la diáspora gallega; la segunda, durante la República Española (1931-1936), etapa definida por su actividad política en Galicia con vinculaciones a la causa nacionalista y al movimiento agrarista; la tercera, su experiencia como «huido», consecuencia de la represión fascista a la que fue sometido durante la guerra civil; por último, el destierro en Buenos Aires hasta su muerte, dando presencia y continuidad al gobierno gallego en el exilio con el Consello de Galiza. Para ello se ha revisado diversa bibliografía relacionada con la emigración gallega a América y con la represión franquista en Galicia; se ha consultado prensa periódica gallega y americana de la época; se han revisado los fondos del Archivo provincial de la Diputación de Pontevedra, del Arquivo da Emigración del Consello da Cultura Galega (Santiago de Compostela) y se ha consultado diversa documentación societaria ubicada en archivos personales.
Escenarios dominicanos de la escuela republicana en el exilio, 1939-1945
Authors: Alfonseca Giner de los Rìos Juan Bernardo
Published: January 2019

Este escrito describe la participación de los refugiados españoles en la enseñanza dominicana entre 1939 y 1945, lapso en el que arribaron y partieron los casi cuatro mil exilados que recibió la República Dominicana. Se trata de un estudio preliminar que procura, por una parte, ampliar el conocimiento sobre el impacto y la obra de los republicanos españoles en el país (trayendo a la luz referencias sobre los centros escolares que establecieron —que fueron 29 y no 6 como ha solido creerse—, así como apreciaciones sobre su participación dentro del sistema escolar dominicano), al tiempo que intenta, por otra, comprender los procesos de apropiación sociocultural de la escuela republicana en el exilio que tomaron lugar en la sociedad dominicana de entonces.
Educación de las Infancias: entre el Hogar y la Escuela (1880-1915)
Authors: Martínez Ruiz-Funes María José
Published: January 2019

Reseña del libro de María Isabel Orellana Rivera y Nicole Araya Oñate, Educación de las Infancias: entre el Hogar y la Escuela (1880-1915). Santiago de Chile: Ediciones Museo de la Educación Gabriela Mistral, 2016.
El exilio pedagógico de 1939
Authors: Marquès i Sureda Salomó , Cruz Orozco José Ignacio
Published: January 2019

Presentación del número monográfico
Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub
Authors: Borgen Melissa A , Giles Andrew C , Wang Dandan , Grill Brock
Published: January 2019

Synapse formation is comprised of target cell recognition, synapse assembly, and synapse maintenance. Maintaining established synaptic connections is essential for generating functional circuitry and synapse instability is a hallmark of neurodegenerative disease. While many molecules impact synapse formation generally, we know little about molecules that affect synapse maintenance in vivo. Using genetics and developmental time course analysis in C.elegans, we show that the α-tubulin acetyltransferase ATAT-2 and the signaling hub RPM-1 are required presynaptically to maintain stable synapses. Importantly, the enzymatic acetyltransferase activity of ATAT-2 is required for synapse maintenance. Our analysis revealed that RPM-1 is a hub in a genetic network composed of ATAT-2, PTRN-1 and DLK-1. In this network, ATAT-2 functions independent of the DLK-1 MAPK and likely acts downstream of RPM-1. Thus, our study reveals an important role for tubulin acetyltransferase activity in presynaptic maintenance, which occurs via the RPM-1/ATAT-2 pathway.
TOXIC METALS CONTENT AND SAFE USE OF Seseli pallasii HERB
Authors: Ilić Marija , stankov Jovanovic Vesna , Mitić Violeta , Dimitrijević Marija , Cvetković Jelena , Tošić snežana
Published: January 2019

Heavy metals, whether from natural or anthropogenic
sources have the ability to migrate between differ
ent parts of environment and accumulate in flora and fauna, finally reaching humans through food chain. The possibility that plants might be contaminated by heavy metals should be taken into account, when they are intended for use in pharmaceutical and food industry, because increased concentration of some metals may have an adverse effect on human and animal health. Wild medicinal herb Seseli pallasii have been used in traditional medicine as well as a spice in nutrition, hence an assessment of the presence of toxic metals in it is essential in order to ensure its safe application. Vegetative parts of plant S. pallasii (root, leaf, flower and fruit) from Southeast Serbia were analyzed to assess the content of toxic metals (Cd, Cr, Ni and Pb, using inductively coupled plasma with optical emission spectrometry (ICP-OES).
The results have shown that the average concentration of Cd in the aboveground part was almost twice as high 0.21 ppm than in the root 0.11 ppm, concentration of Cr in aerial part was of 0.43ppm, in the root 0.29 ppm, concentration of Ni in the aboveground was of 0.98ppm, while in the root it was of 0.68ppm. The average concentration of Pb in the aboveground part and the root was almost the same (2.31 and 2.15 ppm, respectively). These facts evidenced that the contents of toxic elements in the studied medicinal plant species are below the recommended limits, confirming that S. pallasii from the examined area can be safely used in traditional medicine and nutrition.
Key words: Seseli pallasii, toxic metals, ICP, safety
.
TOTAL CONTENT OF ORGANIC ACIDS IN PLANTS COLLECTED SECOND YEAR AFTER THE WILD FIRE
Authors: Stamenković Slaviša , Marković Marija , stankov Jovanović Vesna , Mitić Violeta , Ilić Marija
Published: January 2019

The wild fire, which occurred in the summer of 2007 in the
mountain Vidlič (Southeast Serbia) destroyed large areas of be
ech and oak forests, dry meadows and rocky terrains. The aim of the present study was to investigate the effect of wild fire on the organic acids content in underground and above-ground parts of plants Geranium macrorhizum, Doronicum columnae, Glechoma hir
suta, Chelidonium majus and Primula veris, second year after the accident. As a control material were used samples of plants from areas that were not exposed to fire.
Key words:
organic acids, wild fire, Geraniaceae, Asteraceae, Lamiaceae, Papaveraceae, Primulaceae.
ANALYSIS OF CRITICAL CONTROL POINTS IN MEAT INDUSTRY
Authors: Lazarević Vesna , Stanisavljević Miodrag
Published: January 2019

The technology of meat processing involves the processes and operations which lead to the emission of harmful gases,
wastewaters and sludge. In order to monitor more easily and to
remove the possible causes, this paper analyses the critical points of
the technology of meat processing as well as the consequences of
undesired events, aiming at reducing the risk level.
Key words:
meat industry, wastewater, critical control points
Seasonality and trend prediction of scarlet fever incidence in mainland China from 2004 to 2018 using a hybrid SARIMA-NARX model
Authors: Wang Yongbin , Xu Chunjie , Wang Zhende , Yuan Juxiang
Published: January 2019

Background

Scarlet fever is recognized as being a major public health issue owing to its increase in notifications in mainland China, and an advanced response based on forecasting techniques is being adopted to tackle this. Here, we construct a new hybrid method incorporating seasonal autoregressive integrated moving average (SARIMA) with a nonlinear autoregressive with external input(NARX) to analyze its seasonality and trend in order to efficiently prevent and control this re-emerging disease.

Methods

Four statistical models, including a basic SARIMA, basic nonlinear autoregressive (NAR) method, traditional SARIMA-NAR and new SARIMA-NARX hybrid approaches, were developed based on scarlet fever incidence data between January 2004 and July 2018 to evaluate its temporal patterns, and their mimic and predictive capacities were compared to discover the optimal using the mean absolute percentage error, root mean square error, mean error rate, and root mean square percentage error.

Results

The four preferred models identified were comprised of the SARIMA(0,1,0)(0,1,1)12, NAR with 14 hidden neurons and five delays, SARIMA-NAR with 33 hidden neurons and five delays, and SARIMA-NARX with 16 hidden neurons and 4 delays. Among which presenting the lowest values of the aforementioned indices in both simulation and prediction horizons is the SARIMA-NARX method. Analyses from the data suggested that scarlet fever was a seasonal disease with predominant peaks of summer and winter and a substantial rising trend in the scarlet fever notifications was observed with an acceleration of 9.641% annually, particularly since 2011 with 12.869%, and moreover such a trend will be projected to continue in the coming year.

Conclusions

The SARIMA-NARX technique has the promising ability to better consider both linearity and non-linearity behind scarlet fever data than the others, which significantly facilitates its prevention and intervention of scarlet fever. Besides, under current trend of ongoing resurgence, specific strategies and countermeasures should be formulated to target scarlet fever.
Monomeric Covalent‐Avidin for Rapid and Covalent Labeling of Quantum Dots to Cell Surface Proteins
Authors: Choi Hyeokjune , Lee Jeong Min , Jung Yongwon
Published: January 2019

With high brightness and photostability, quantum dots (QDs) are potent probes for long‐term imaging of dynamic cell surface proteins, but practical methods to covalently label QDs to target proteins for stable imaging are largely lacking. Here, a small covalent‐bond forming protein (Covalent‐avidin)/peptide pair is introduced, which provides a recombinant protein‐based rapid and covalent QD labeling strategy. Covalent‐avidin is constructed by optimized fusion of circular permuted monomeric avidin to SpyCatcher, which forms an isopeptide bond with the SpyTag peptide. Covalent‐avidin‐conjugated QDs allow for strong and irreversible QD labeling to the biotinylated SpyTag‐fused adrenergic receptor on live cells in 2 min. In addition, QDs with only a minimum number of conjugated Covalent‐avidin show more stable receptor labeling than commercially available streptavidin‐conjugated QDs, also with minimal unwanted clustering of labeled receptors. Monomeric Covalent‐avidin will be a valuable protein linker for diverse other nanolabeling structures with beneficial properties such as covalent linkages and facile valency control.
Thermodynamic Stability Landscape of Halide Double Perovskites via High‐Throughput Computing and Machine Learning
Authors: Li Zhenzhu , Xu Qichen , Sun Qingde , Hou Zhufeng , Yin Wan‐Jian
Published: January 2019

Formability and stability issues are of core importance and difficulty in current research and applications of perovskites. Nevertheless, over the past century, determination of the formability and stability of perovskites has relied on semiempirical models derived from physics intuition, such as the commonly used Goldschmidt tolerance factor, t. Here, through high‐throughput density functional theory (DFT) calculations, a database containing the decomposition energies, considered to be closely related to the thermodynamic stability of 354 halide perovskite candidates, is established. To map the underlying relationship between the structure and chemistry features and the decomposition energies, a well‐functioned machine learning (ML) model is trained over this theory‐based database and further validated by experimental observations of perovskite formability (F1 score, 95.9%) of 246 A2B(I)B(III)X6 compounds that are not present in the training database; the model performs a lot better than empirical descriptors such as tolerance factor t (F1 score, 77.5%). This work demonstrates that the experimental engineering of stable perovskites by ML could solely rely on training data derived from high‐throughput DFT computing, which is much more economical and efficient than experimental attempts at materials synthesis.
Nip the Sodium Dendrites in the Bud on Planar Doped Graphene in Liquid/Gel Electrolytes
Authors: Hu Xiaofei , Joo Paul Hyunggyu , Wang Huan , Matios Edward , Wang Chuanlong , Luo Jianmin , Lu Xuan , Yang Kesong , Li Weiyang
Published: January 2019

Sodium (Na) metal is the most promising alternative anode to metallic lithium for high‐energy batteries due to the low cost and high abundance of Na resources, but it suffers from severe dendritic/mossy growth at high current densities. Understanding Na nucleation/growth mechanism in different electrolyte systems is the key to tackling this issue but is complicated by the structural complexities of existing substrates for Na plating/stripping. Herein, well‐defined planar doped graphene substrates are synthesized as model plating platforms to unravel a binding energy dominant Na nucleation‐growth mode. The dopants (e.g., boron) in doped graphene and the regions close to the dopants possess high binding energies with Na atoms, providing abundant preferential nucleation sites and contributing to uniform Na plating/stripping. Accordingly, the boron‐doped graphene regulated Na anode exhibits long‐term stability at high current densities in both liquid and polymer electrolytes. The results enhance the understanding of Na nucleation/growth for stabilizing Na metal batteries.
Activating MoS2 Basal Plane with Ni2P Nanoparticles for Pt‐Like Hydrogen Evolution Reaction in Acidic Media
Authors: Kim Minkyung , Anjum Mohsin Ali Raza , Lee Minhee , Lee Byeong Jun , Lee Jae Sung
Published: January 2019

2D molybdenum disulfide (MoS2) displays a modest hydrogen evolution reaction (HER) activity in acidic media because the active sites are limited to a small number of edge sites with broader basal planes remaining mostly inert. Here, it is reported that the MoS2 basal planes could be activated by growing nickel phosphide (Ni2P) nanoparticles on them. Thus a Ni2P/MoS2 heterostructure is constructed via in situ phosphidation of an indigenously synthesized NiMoS4 salt as a single precursor to form a widely cross‐doped and chemically connected heterostructure. The conductivity and stability of the Ni2P/MoS2 heterostructure are further enhanced by hybridization with conductive N‐doped carbon supports. As a result, the Ni2P/MoS2/N:RGO or Ni2P/MoS2/N:CNT electrocatalyst displays Pt‐like HER performance in acidic media, outperforming the incumbent best HER electrocatalyst, Pt/C, in a more meaningful high current density region (>200 mA cm−2) making them a promising candidate for practical water electrolysis applications. Since nonprecious metal catalysts showing Pt‐like HER performance in acidic media are rare, the Ni2P/MoS2 heterostructure catalyst is a promising candidate for practical hydrogen production via water electrolysis.
12.5% Flexible Nonfullerene Solar Cells by Passivating the Chemical Interaction Between the Active Layer and Polymer Interfacial Layer
Authors: Xiong Sixing , Hu Lin , Hu Lu , Sun Lulu , Qin Fei , Liu Xianjie , Fahlman Mats , Zhou Yinhua
Published: January 2019

Nonfullerene (NF) organic solar cells (OSCs) have been attracting significant attention in the past several years. It is still challenging to achieve high‐performance flexible NF OSCs. NF acceptors are chemically reactive and tend to react with the low‐temperature‐processed low‐work‐function (low‐WF) interfacial layers, such as polyethylenimine ethoxylated (PEIE), which leads to the “S” shape in the current‐density characteristics of the cells. In this work, the chemical interaction between the NF active layer and the polymer interfacial layer of PEIE is deactivated by increasing its protonation. The PEIE processed from aqueous solution shows more protonated N+ than that processed from isopropyl alcohol solution, observed from X‐ray photoelectron spectroscopy. NF solar cells (active layer: PCE‐10:IEICO‐4F) with the protonated PEIE interfacial layer show an efficiency of 13.2%, which is higher than the reference cells with a ZnO interlayer (12.6%). More importantly, the protonated PEIE interfacial layer processed from aqueous solution does not require a further thermal annealing treatment (only processing at room temperature). The room‐temperature processing and effective WF reduction enable the demonstration of high‐performance (12.5%) flexible NF OSCs.
Homozygous/compound heterozygote RYR1 gene variants: Expanding the clinical spectrum
Authors: Alkhunaizi Ebba , Shuster Shirley , Shannon Patrick , Siu Victoria Mok , Darilek Sandra , Mohila Carrie A , Boissel Sarah , Ellezam Benjamin , Fallet‐Bianco Catherine , Laberge Anne‐Marie , Zandberg Julianne , Injeyan Marie , Hazrati Lili‐Naz , Hamdan Fadi , Chitayat David
Published: January 2019

The ryanodine receptor 1 (RYR1) is a calcium release channel essential for excitation‐contraction coupling in the sarcoplasmic reticulum of skeletal muscles. Dominant variants in the RYR1 have been well associated with the known pharmacogenetic ryanodinopathy and malignant hyperthermia. With the era of next‐generation gene sequencing and growing number of causative variants, the spectrum of ryanodinopathies has been evolving with dominant and recessive variants presenting with RYR1‐related congenital myopathies such as central core disease, minicore myopathy with external ophthalmoplegia, core‐rod myopathy, and congenital neuromuscular disease. Lately, the spectrum was broadened to include fetal manifestations, causing a rare recessive and lethal form of fetal akinesia deformation sequence syndrome (FADS)/arthrogryposis multiplex congenita (AMC) and lethal multiple pterygium syndrome. Here we broaden the spectrum of clinical manifestations associated with homozygous/compound heterozygous RYR1 gene variants to include a wide range of manifestations from FADS through neonatal hypotonia to a 35‐year‐old male with AMC and PhD degree. We report five unrelated families in which three presented with FADS. One of these families was consanguineous and had three affected fetuses with FADS, one patient with neonatal hypotonia who is alive, and one individual with AMC who is 35 years old with normal intellectual development and uses a wheelchair. Muscle biopsies on these cases demonstrated a variety of histopathological abnormalities, which did not assist with the diagnostic process. Neither the affected living individuals nor the parents who are obligate heterozygotes had history of malignant hyperthermia.
Enhanced Lithium‐Ion Conductivity of Polymer Electrolytes by Selective Introduction of Hydrogen into the Anion
Authors: Zhang Heng , Oteo Uxue , Zhu Haijin , Judez Xabier , Martinez‐Ibañez Maria , Aldalur Itziar , Sanchez‐Diez Eduardo , Li Chunmei , Carrasco Javier , Forsyth Maria , Armand Michel
Published: January 2019

The anion chemistry of lithium salts plays a pivotal role in dictating the physicochemical and electrochemical performance of solid polymer electrolytes (SPEs), thus affecting the cyclability of all‐solid‐state lithium metal batteries (ASSLMBs). The bis(trifluoromethanesulfonyl)imide anion (TFSI−) has long been studied as the most promising candidate for SPEs; however, the Li‐ion conductivities of the TFSI‐based SPEs still remain low (Li‐ion transference number: ca. 0.2). In this work, we report new hydrogen‐containing anions, conceived based on theoretical considerations, as an electrolyte salt for SPEs. SPEs comprising hydrogen‐containing anions achieve higher Li‐ion conductivities than TFSI‐based ones, and those anions are electrochemically stable for various kinds of ASSLMBs (Li–LiFePO4, Li–S, and Li–O2 batteries). This opens up a new avenue for designing safe and high‐performance ASSLMBs in the future.
Directional Threading and Sliding of a Dissymmetrical Foldamer Helix on Dissymmetrical Axles
Authors: Wang Xiang , Gan Quan , Wicher Barbara , Ferrand Yann , Huc Ivan
Published: January 2019

We have investigated the self‐assembly of a dissymmetrical aromatic oligoamide helix on linear amido‐carbamate rods. A dissymmetric sequence bearing two differentiated ends is able to wrap around dissymmetric dumbbell guest molecules. Structural and thermodynamic investigations allowed us to decipher the mode of binding of the helix that can bind specifically to the amide and carbamate groups of the rod. In parallel kinetic studies of threading and sliding of the helix along linear axles were also monitored by 1H NMR. Results show that threading of a dissymmetrical host can be kinetically biased by the nature of the guest terminus allowing a preferential sense of sliding of the helix. The study presented below further demonstrates the valuable potential of foldaxanes to combine designed molecular recognition patterns with fine control of self‐assembly kinetics to conceive complex supramolecular events.
Direct Catalytic Asymmetric Aldol Reaction of α‐Alkoxyamides to α‐Fluorinated Ketones
Authors: Pluta Roman , Kumagai Naoya , Shibasaki Masakatsu
Published: January 2019

α‐Oxygen‐functionalized amides found particular utility as enolate surrogates for direct aldol couplings with α‐fluorinated ketones in a catalytic manner. Because of the likely involvement of open transition states, both syn‐ and anti‐aldol adducts can be accessed with high enantioselectivity by judicious choice of the chiral ligands. A broad variety of alkoxy substituents on the amides and aryl and fluoroalkyl groups on the ketone were tolerated, and the corresponding substrates delivered a range of enantioenriched fluorinated 1,2‐dihydroxycarboxylic acid derivatives with divergent diastereoselectivity depending on the ligand used. The amide moiety of the aldol adduct was transformed into a variety of functional groups without protection of the tertiary alcohol, showcasing the synthetic utility of the present asymmetric aldol process.
Blast furnace slag or fly ash filled rigid polyurethane composite foams: A comprehensive investigation
Authors: Akkoyun Meral , Akkoyun Serife
Published: January 2019

Ground granulated blast furnace slag (BFS) and fly ash (FA) are iron‐making industry and power plant byproducts, respectively. Although their use in concrete is quite common, investigation of the effects of these inorganic compounds on polymer properties is quite new, and their use as fillers in polymer foam composites has not yet been really explored. Their properties, such as high electrical resistivity, make them a good asset for use in rigid polyurethane foams that are widely used for insulation. In this study, a comprehensive investigation of the effect of BFS and FA on morphology, electrical and thermal conductivity, and rheological and mechanical properties of water‐blown rigid polyurethane foams was performed. The relationship between these properties was examined. A relative enhancement of the properties is observed for filled foams, especially up to the percolation threshold. The results highlight a noticeable effect of the electrical percolation threshold on the different properties of foams. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47433.
Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes
Authors: Takahashi Tsuyoshi , Uno Yasuhiro , Yamazaki Hiroshi , Kume Toshiyuki
Published: January 2019

The hepatic uptake of clinical drugs mediated by human hepatic organic anion transporting polypeptides (OATP/SLCO) has been reported extensively. In this study, hepatic uptake by recombinantly expressed monkey OATP1B1, OATP1B3 and OATP2B1 was investigated using three human OATP1B1 and OATP1B3 substrates (pitavastatin, pravastatin and rosuvastatin) and one OATP1B3 substrate (telmisartan), as the governmental drug interaction guidelines recommend, and seven reported clinical drugs. The uptake of known human probes into recombinant OATP‐expressing cells was significantly greater than that of mock cells. Consequently, pitavastatin, pravastatin and rosuvastatin were suggested to be substrates of recombinant monkey OATP1B1 and OATP1B3, and telmisartan was suggested to be a substrate of recombinant monkey OATP1B3, in a manner similar to human OATPs. In contrast, atorvastatin, bosentan, etoposide, fexofenadine, fluvastatin, glibenclamide and simeprevir were broadly transported by recombinant monkey OATP1B1, OATP1B3 and OATP2B1. Furthermore, some of the 16 non‐synonymous monkey OATP1B1 variants found in 64 cynomolgus and 32 rhesus monkeys mediated up to a 1.6‐fold [3H]pitavastatin uptake (with low Michaelis constant values) in comparison with the wild type under the present conditions. Despite sequences of monkey recombinant OATPs not being totally reflective of those of human OATPs, our results collectively suggested that OATP1B1, OATP1B3 or OATP2B1 in monkeys could mediate roughly a similar hepatic uptake of various OATP probes. Recombinant monkey OATPs would be good experimental tools for in vitro hepatic uptake in cell systems.