bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute Kidney Injury Predicts Mortality after Charcoal Burning Suicide
Authors: Chen Yu-Chin , Tseng Yi-Chia , Huang Wen-Hung , Hsu Ching-Wei , Weng Cheng-Hao , Liu Shou-Hsuan , Yang Huang-Yu , Chen Kuan-Hsin , Chen Hui-Ling , Fu Jen-Fen , Lin Wey-Ran , Wang I-Kuan , Yen Tzung-Hai
Published: July 2016

A paucity of literature exists on risk factors for mortality in charcoal burning suicide. In this observational study, we analyzed the data of 126 patients with charcoal burning suicide that seen between 2002 and 2013. Patients were grouped according to status of renal damage as acute kidney injury (N = 49) or non-acute kidney injury (N = 77). It was found that patients with acute kidney injury suffered severer complications such as respiratory failure (P = 0.002), myocardial injury (P = 0.049), hepatic injury (P < 0.001), rhabdomyolysis (P = 0.045) and out-of-hospital cardiac arrest (P = 0.028) than patients without acute kidney injury. Moreover, patients with acute kidney injury suffered longer hospitalization duration (16.9 ± 18.3 versus 10.7 ± 10.9, P = 0.002) and had higher mortality rate (8.2% versus 0%, P = 0.011) than patients without injury. In a multivariate Cox regression model, it was demonstrated that serum creatinine level (P = 0.019) and heart rate (P = 0.022) were significant risk factors for mortality. Finally, Kaplan-Meier analysis revealed that patients with acute kidney injury suffered lower cumulative survival than without injury (P = 0.016). In summary, the overall mortality rate of charcoal burning suicide population was 3.2% and acute kidney injury was a powerful predictor of mortality. Further studies are warranted.
Yeast metabolic chassis designs for diverse biotechnological products
Authors: Jouhten Paula , Boruta Tomasz , Andrejev Sergej , Pereira Filipa , Rocha Isabel , Patil Kiran Raosaheb
Published: July 2016

The diversity of industrially important molecules for which microbial production routes have been experimentally demonstrated is rapidly increasing. The development of economically viable producer cells is, however, lagging behind, as it requires substantial engineering of the host metabolism. A chassis strain suitable for production of a range of molecules is therefore highly sought after but remains elusive. Here, we propose a genome-scale metabolic modeling approach to design chassis strains ofSaccharomyces cerevisiae– a widely used microbial cell factory. For a group of 29 products covering a broad range of biochemistry and applications, we identified modular metabolic engineering strategies for re-routing carbon flux towards the desired product. We find distinct product families with shared targets forming the basis for the corresponding chassis cells. The design strategies include overexpression targets that group products by similarity in precursor and cofactor requirements, as well as gene deletion strategies for growth-product coupling that lead to non-intuitive product groups. Our results reveal the extent and the nature of flux re-routing necessary for producing a diverse range of products in a widely used cell factory and provide blueprints for constructing pre-optimized chassis strains.
Dislocations and deformation microstructure in a B2-ordered Al28Co20Cr11Fe15Ni26 high-entropy alloy
Authors: Feuerbacher Michael
Published: July 2016

High-entropy alloys are multicomponent metallic materials currently attracting high research interest. They display a unique combination of chemical disorder and crystalline long-range order and due to their attractive properties are promising candidates for technological application. Many high-entropy alloys possess surprisingly high strength, occasionally in combination with high ductility and low density. The mechanisms effecting these attractive mechanical properties are not understood. This study addresses the deformation mechanism of a Al28Co20Cr11Fe15Ni26 high-entropy alloy, which is a two-phase material, consisting of a B2-ordered matrix and disordered body-centred inclusions. We quantitatively analyse the microstructure and dislocations in deformed samples by transmission-electron-microscopic methods including weak-beam imaging and convergent-beam electron diffraction. We find that the deformation process in the B2 phase is dominated by heterogeneous slip of "Equation missing" screw dislocations gliding on "Equation missing" planes. The dislocations are perfect superdislocations of the B2 lattice and show no dissociation. This indicates that the antiphase-boundary energy in the structure is very high, inhibiting spread of the dislocation core. Along with the observation of a widely extending strain field associated to the dislocations, our results provide a possible explanation for the high strength of this high-entropy alloy as a direct consequence of its dislocation structure.
Age-specific haemosporidian infection dynamics and survival in Seychelles warblers
Authors: Hammers Martijn , Komdeur Jan , Kingma Sjouke A. , Hutchings Kimberly , Fairfield Eleanor A. , Gilroy Danielle L. , Richardson David S.
Published: July 2016

Parasites may severely impact the fitness and life-history of their hosts. After infection, surviving individuals may suppress the growth of the parasite, or completely clear the infection and develop immunity. Consequently, parasite prevalence is predicted to decline with age. Among elderly individuals, immunosenescence may lead to a late-life increase in infection prevalence. We used a 21-year longitudinal dataset from one population of individually-marked Seychelles warblers (Acrocephalus sechellensis) to investigate age-dependent prevalence of the GRW1 strain of the intracellular protozoan blood parasite Haemoproteus nucleocondensus and whether infections with this parasite affect age-dependent survival. We analyzed 2454 samples from 1431 individuals and found that H. nucleocondensus infections could rarely be detected in nestlings. Prevalence increased strongly among fledglings and peaked among older first year birds. Prevalence was high among younger adults and declined steeply until ca 4 years of age, after which it was stable. Contrary to expectations, H. nucleocondensus prevalence did not increase among elderly individuals and we found no evidence that annual survival was lower in individuals suffering from an infection. Our results suggest that individuals clear or suppress infections and acquire immunity against future infections, and provide no evidence for immunosenescence nor an impact of chronic infections on survival.
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer
Authors: Kim Nayoung , Yim Hwa Young , He Ningning , Lee Cheol-Jung , Kim Ju Hyun , Choi Jin-Sung , Lee Hye Suk , Kim Somin , Jeong Euna , Song Mee , Jeon Sang-Min , Kim Woo-Young , Mills Gordon B. , Cho Yong-Yeon , Yoon Sukjoon
Published: July 2016

Although STK11 (LKB1) mutation is a major mediator of lung cancer progression, targeted therapy has not been implemented due to STK11 mutations being loss-of-function. Here, we report that targeting the Na+/K+-ATPase (ATP1A1) is synthetic lethal with STK11 mutations in lung cancer. The cardiac glycosides (CGs) digoxin, digitoxin and ouabain, which directly inhibit ATP1A1 function, exhibited selective anticancer effects on STK11 mutant lung cancer cell lines. Restoring STK11 function reduced the efficacy of CGs. Clinically relevant doses of digoxin decreased the growth of STK11 mutant xenografts compared to wild type STK11 xenografts. Increased cellular stress was associated with the STK11-specific efficacy of CGs. Inhibiting ROS production attenuated the efficacy of CGs, and STK11-AMPK signaling was important in overcoming the stress induced by CGs. Taken together, these results show that STK11 mutation is a novel biomarker for responsiveness to CGs. Inhibition of ATP1A1 using CGs warrants exploration as a targeted therapy for STK11 mutant lung cancer.
Prevalence of Atopic Dermatitis in Chinese Children aged 1–7 ys
Authors: Guo Yifeng , Li Ping , Tang Jianping , Han Xiuping , Zou Xiaoyan , Xu Gang , Xu Zigang , Wei Fenglei , Liu Qiang , Wang Min , Xiao Fengli , Zong Wenkai , Shen Chunping , Li Jianhong , Liu Jianzhong , Luo Yongqi , Chang Jing , Sheng Nan , Dong Chun , Zhang Duo , Dai Xing , Zhou Jinjie , Meng Chi , Niu Hongxi , Shi Xuemei , Zhang Xinglian , Xiang Juan , Xu Haitao , Ran Qin , Zhou Yi , Li Ming , Zhang Hui , Cheng Ruhong , Gao Xinghua , Wang Hua , Gu Heng , Ma Lin , Yao Zhirong
Published: July 2016

Prevalence of atopic dermatitis (AD) is increasing worldwide. Up to date, there has been no face-to-face nation-wide study in China. We aim to explore the prevalence of clinical diagnosed AD in children aged 1–7 ys in China. Twelve metropolises were chosen from different areas of China. In each region, we selected 4–10 kindergartens and 2–5 vaccination clinics randomly. A complete history-taking and skin examination were performed by dermatologists. The definite diagnosis of AD and the severity were determined by two or three dermatologists. All criteria concerned in UK diagnosis criteria, characteristic presentation of AD and atypical manifestations were recorded in detail. A total of 13998 children from 84 kindergartens and 40 vaccination clinics were included. The prevalence of AD was 12.94% by clinical diagnosis of dermatologists overall, with 74.6% of mild AD. Comparatively, prevalence of AD based on UK diagnostic criteria was 4.76%. This is the first face-to-face nation-wide study in Chinese children aged 1–7 ys, revealing that the prevalence of AD in children is closer to that of wealthier nations.
VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease
Authors: Díaz-Alonso Javier , Paraíso-Luna Juan , Navarrete Carmen , del Río Carmen , Cantarero Irene , Palomares Belén , Aguareles José , Fernández-Ruiz Javier , Bellido María Luz , Pollastro Federica , Appendino Giovanni , Calzado Marco A. , Galve-Roperh Ismael , Muñoz Eduardo
Published: July 2016

Cannabinoids have shown to exert neuroprotective actions in animal models by acting at different targets including canonical cannabinoid receptors and PPARγ. We previously showed that VCE-003, a cannabigerol (CBG) quinone derivative, is a novel neuroprotective and anti-inflammatory cannabinoid acting through PPARγ. We have now generated a non-thiophilic VCE-003 derivative named VCE-003.2 that preserves the ability to activate PPARγ and analyzed its neuroprotective activity. This compound exerted a prosurvival action in progenitor cells during neuronal differentiation, which was prevented by a PPARγ antagonist, without affecting neural progenitor cell proliferation. In addition, VCE-003.2 attenuated quinolinic acid (QA)-induced cell death and caspase-3 activation and also reduced mutant huntingtin aggregates in striatal cells. The neuroprotective profile of VCE-003.2 was analyzed using in vivo models of striatal neurodegeneration induced by QA and 3-nitropropionic acid (3NP) administration. VCE-003.2 prevented medium spiny DARPP32+ neuronal loss in these Huntington’s-like disease mice models improving motor deficits, reactive astrogliosis and microglial activation. In the 3NP model VCE-003.2 inhibited the upregulation of proinflammatory markers and improved antioxidant defenses in the brain. These data lead us to consider VCE-003.2 to have high potential for the treatment of Huntington’s disease (HD) and other neurodegenerative diseases with neuroinflammatory traits.
Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance
Authors: Frise Rebecca , Bradley Konrad , van Doremalen Neeltje , Galiano Monica , Elderfield Ruth A. , Stilwell Peter , Ashcroft Jonathan W. , Fernandez-Alonso Mirian , Miah Shahjahan , Lackenby Angie , Roberts Kim L. , Donnelly Christl A. , Barclay Wendy S.
Published: July 2016

Influenza viruses cause annual seasonal epidemics and occasional pandemics. It is important to elucidate the stringency of bottlenecks during transmission to shed light on mechanisms that underlie the evolution and propagation of antigenic drift, host range switching or drug resistance. The virus spreads between people by different routes, including through the air in droplets and aerosols, and by direct contact. By housing ferrets under different conditions, it is possible to mimic various routes of transmission. Here, we inoculated donor animals with a mixture of two viruses whose genomes differed by one or two reverse engineered synonymous mutations, and measured the transmission of the mixture to exposed sentinel animals. Transmission through the air imposed a tight bottleneck since most recipient animals became infected by only one virus. In contrast, a direct contact transmission chain propagated a mixture of viruses suggesting the dose transferred by this route was higher. From animals with a mixed infection of viruses that were resistant and sensitive to the antiviral drug oseltamivir, resistance was propagated through contact transmission but not by air. These data imply that transmission events with a looser bottleneck can propagate minority variants and may be an important route for influenza evolution.
Novel technique to suppress hydrocarbon contamination for high accuracy determination of carbon content in steel by FE-EPMA
Authors: Yamashita Takako , Tanaka Yuji , Nagoshi Masayasu , Ishida Kiyohito
Published: July 2016

In multiphase steels, control of the carbon contents in the respective phases is the most important factor in alloy design for achieving high strength and high ductility. However, it is unusually difficult to determine the carbon contents in multiphase structures with high accuracy by electron probe microanalysis (EPMA) due to the unavoidable effect of hydrocarbon contamination during measurements. We have investigated new methods for suppressing hydrocarbon contamination during field emission (FE) EPMA measurements as well as a conventional liquid nitrogen trap. Plasma cleaner inside the specimen chamber results in a improvement of carbon-content determination by point analysis, increasing precision tenfold from the previous 0.1 mass%C to 0.01 mass%C. Stage heating at about 100 °C dramatically suppresses contamination growth during continuous point measurement and mapping. By the combination of above two techniques, we successfully visualized the two-dimensional carbon distribution in a dual-phase steel. It was also noted that the carbon concentrations at the ferrite/martensite interfaces were not the same across all interfaces, and local variation was observed. The developed technique is expected to be a powerful tool for understanding the mechanisms of mechanical properties and microstructural evolution, thereby contributing to the design of new steel products with superior properties.
Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells
Authors: Liu Yang , Wang Shujun , Sun Dongsheng , Liu Yongdong , Liu Yang , Wang Yang , Liu Chang , Wu Hao , Lv Yan , Ren Ying , Guo Xin , Sun Guangwei , Ma Xiaojun
Published: July 2016

Tumor metastasis with resistance to anticancer therapies is the main cause of death in cancer patients. It is necessary to develop reliable tumor metastasis models that can closely recapitulate the pathophysiological features of the native tumor tissue. In this study, chondroitin sulfate (CS)-modified alginate hydrogel beads (ALG-CS) are developed to mimic the in vivo tumor microenvironment with an abnormally increased expression of CS for the promotion of tumor cell metastasis. The modification mechanism of CS on alginate hydrogel is due to the cross-linking between CS and alginate molecules via coordination of calcium ions, which enables ALG-CS to possess significantly different physical characteristics than the traditional alginate beads (ALG). And quantum chemistry calculations show that in addition to the traditional egg-box structure, novel asymmetric egg-box-like structures based on the interaction between these two kinds of polymers are also formed within ALG-CS. Moreover, tumor cell metastasis is significantly enhanced in ALG-CS compared with that in ALG, as confirmed by the increased expression of MMP genes and proteins and greater in vitro invasion ability. Therefore, ALG-CS could be a convenient and effective 3D biomimetic scaffold that would be used to construct standardized tumor metastasis models for tumor research and anticancer drug screening.
Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation
Authors: Carthy Jon M. , Stöter Martin , Bellomo Claudia , Vanlandewijck Michael , Heldin Angelos , Morén Anita , Kardassis Dimitris , Gahman Timothy C. , Shiau Andrew K. , Bickle Marc , Zerial Marino , Heldin Carl-Henrik , Moustakas Aristidis
Published: July 2016

Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful. Using human keratinocytes and a robotic high-content imaging platform, we screened for chemical compounds that reverse transforming growth factor β (TGF-β)-induced epithelial-mesenchymal transition. In addition to TGF-β receptor kinase inhibitors, we identified small molecule epithelial plasticity modulators including a naturally occurring hydroxysterol agonist of the liver X receptors (LXRs), members of the nuclear receptor transcription factor family. Endogenous and synthetic LXR agonists tested in diverse cell models blocked α-smooth muscle actin expression, myofibroblast differentiation and function. Agonist-dependent LXR activity or LXR overexpression in the absence of ligand counteracted TGF-β-mediated myofibroblast terminal differentiation and collagen contraction. The protective effect of LXR agonists against TGF-β-induced pro-fibrotic activity raises the possibility that anti-lipidogenic therapy may be relevant in fibrotic disorders and advanced cancer.
Interleukin-1β, lipocalin 2 and nitric oxide synthase 2 are mechano-responsive mediators of mouse and human endothelial cell-osteoblast crosstalk
Authors: Veeriah Vimal , Zanniti Angelo , Paone Riccardo , Chatterjee Suvro , Rucci Nadia , Teti Anna , Capulli Mattia
Published: July 2016

Endothelial cells are spatially close to osteoblasts and regulate osteogenesis. Moreover, they are sensitive to mechanical stimuli, therefore we hypothesized that they are implicated in the regulation of bone metabolism during unloading. Conditioned media from endothelial cells (EC-CM) subjected to simulated microgravity (0.08gand 0.008g) increased osteoblast proliferation and decreased their differentiation compared to unit gravity (1g) EC-CM. Microgravity-EC-CM increased the expression of osteoblastRankland subsequent osteoclastogenesis and induced the osteoblast de-differentiating factor, Lipocalin 2 (Lcn2), whose downregulation recovered osteoblast activity, decreasedRanklexpression and reduced osteoclastogenesis. Microgravity-EC-CM enhanced osteoblastNO-Synthase2 (NOS2) andCycloOXygenase2 (COX2) expression. Inhibition of NOS2 or NO signaling reduced osteoblast proliferation and rescued their differentiation. Nuclear translocation of the Lcn2/NOS2 transcription factor, NF-κB, occurred in microgravity-EC-CM-treated osteoblasts and in microgravity-treated endothelial cells, alongside high expression of the NF-κB activator, IL-1β. IL-1β depletion and NF-κB inhibition reduced osteoblast proliferation and rescued differentiation.Lcn2andNOS2were incremented inex vivocalvarias cultured in microgravity-EC-CM andin vivotibias and calvarias injected with microgravity-EC-CM. Furthermore, tibias of botulin A toxin-treated and tail-suspended mice, which featured unloading and decreased bone mass, showed higher expression ofIL-1β, Lcn2andNos2, suggesting their pathophysiologic involvement in endothelial cell-osteoblast crosstalk.
Novel avian influenza A (H5N6) viruses isolated in migratory waterfowl before the first human case reported in China, 2014
Authors: Bi Yuhai , Liu Haizhou , Xiong Chaochao , Di Liu  , Shi Weifeng , Li Mingxin , Liu Siling , Chen Jing , Chen Guang , Li Yong , Yang Guoxiang , Lei Yongsong , Xiong Yanping , Lei Fumin , Wang Hanzhong , Chen Quanjiao , Chen Jianjun , Gao George F.
Published: July 2016

In May 2014, China formally confirmed the first human infection with the novel H5N6 avian influenza virus (AIV) in Sichuan Province. Before the first human case was reported, surveillance of AIVs in wild birds resulted in the detection of three H5N6 viruses in faecal samples from migratory waterfowl in Chenhu wetlands, Hubei Province, China. Genetic and phylogenetic analyses revealed that these three novel viruses were closely related to the H5N6 virus that has caused human infections in China since 2014. A Bayesian phylogenetic reconstruction of all eight segments suggests multiple reassortment events in the evolution of these viruses. The hemagglutinin (HA) and neuraminidase (NA) originated from the H5N2 and H6N6 AIVs, respectively, whereas all six internal genes were derived from avian H5N1 viruses. The reassortant may have occurred in eastern China during 2012–2013. A phylogeographic analysis of the HA and NA genes traced the viruses to southern China, from where they spread to other areas via eastern China. A receptor-binding test showed that H5N6 viruses from migratory waterfowl had human-type receptor-binding activity, suggesting a potential for transmission to humans. These data suggest that migratory waterfowl may play a role in the dissemination of novel H5N6 viruses.
Floating photocatalyst of B–N–TiO2/expanded perlite: a sol–gel synthesis with optimized mesoporous and high photocatalytic activity
Authors: Xue Hongbo , Jiang Ya , Yuan Kechun , Yang Tingting , Hou Jianhua , Cao Chuanbao , Feng Ke , Wang Xiaozhi
Published: July 2016

Optimized mesoporous photocatalyst endowed with high specific surface area and large pore size was synthesized by sol–gel method. These large pore mesoporous materials (33.39 nm) were conducive to the movement of larger molecules or groups in pore path and for effective use of active sites. The high specific surface area (SBET, 99.23 m2 g−1) was beneficial to catalytic oxidation on the surface. Moreover, B and N co-doped anatase TiO2 in the presence of Ti–O–B–N and O–Ti–B–N contributed to the pore structure optimization and enhanced photoresponse capacity with a narrow band gap and red shift of absorption. The obtained materials with floating characteristics based on expanded perlite (EP) showed favorable features for photocatalytic activity. The best RhB photodegration rate of B–N–TiO2/EP (6 mg/g, 24 wt% TiO2) reached 99.1% after 5 h in the visible region and 99.8% after 1 h in the UV region. The findings can provide insights to obtain floatable photocatalysts with simple preparation method, optimized mesoporous, co-doping agents, as well as good photocatalytic performance, coverable and reusability. B–N–TiO2/EP has potential applications for practical environmental purification.
Altered responsiveness of BNST and amygdala neurons in trauma-induced anxiety
Authors: Rodríguez-Sierra O E , Goswami S , Turesson H K , Pare D
Published: July 2016

A highly conserved network of brain structures regulates the expression of fear and anxiety in mammals. Many of these structures display abnormal activity levels in post-traumatic stress disorder (PTSD). However, some of them, like the bed nucleus of the stria terminalis (BNST) and amygdala, are comprised of several small sub-regions or nuclei that cannot be resolved with human neuroimaging techniques. Therefore, we used a well-characterized rat model of PTSD to compare neuronal properties in resilient vs PTSD-like rats using patch recordings obtained from different BNST and amygdala regions in vitro. In this model, a persistent state of extreme anxiety is induced in a subset of susceptible rats following predatory threat. Previous animal studies have revealed that the central amygdala (CeA) and BNST are differentially involved in the genesis of fear and anxiety-like states, respectively. Consistent with these earlier findings, we found that between resilient and PTSD-like rats were marked differences in the synaptic responsiveness of neurons in different sectors of BNST and CeA, but whose polarity was region specific. In light of prior data about the role of these regions, our results suggest that control of fear/anxiety expression is altered in PTSD-like rats such that the influence of CeA is minimized whereas that of BNST is enhanced. A model of the amygdalo-BNST interactions supporting the PTSD-like state is proposed.
Investigation of the chemical origin and evidential value of differences in the SERS spectra of blue gel inks
Authors: Ho Yen Cheng , Lee Wendy W. Y. , Bell Steven E. J.
Published: July 2016

Highly swellable polymer films doped with Ag nanoparticle aggregates (poly-SERS films) have been used to record very high signal : noise ratio, reproducible surface-enhanced resonance Raman (SERRS) spectra ofin situdried ink lines and their constituent dyes using both 633 and 785 nm excitation.
Rapid separation of human breast cancer cells from blood using a simple spiral channel device
Authors: Huang Di , Shi Xin , Qian Yi , Tang Wenlai , Liu Linbo , Xiang Nan , Ni Zhonghua
Published: July 2016

A simple spiral channel device is proposed to separate human breast cancer cells from blood, with the advantages of easy fabrication, low flow resistance and no requirement of a sheath flow.
A colorimetric protease activity assay method using engineered procaspase-3 enzymes
Authors: Yang Dokyung , Park Hyeon Ji , Yoo Tae Hyeon
Published: July 2016

A protease assay platform technology based on engineered proenzymes has been developed for diagnosis of diseases.
Classification of iron ore based on acidity and alkalinity by laser induced breakdown spectroscopy coupled with N-nearest neighbours (N3)
Authors: Yan Chunhua , Wang Zhanmei , Ruan Fangqi , Ma Junxiu , Zhang Tianlong , Tang Hongsheng , Li Hua
Published: July 2016

LIBS technique coupled with N3 for classification and identification of four types of iron ore.
Investigation of CdO hexagonal nanoflakes synthesized by a hydrothermal method for liquefied petroleum gas detection
Authors: Xia Weijun , Liu Yanli , Li Junhua , Chen Chao
Published: July 2016

Cadmium oxide (CdO) hexagonal nanoflakes, demonstrated clearly in an SEM image, were synthesized via a one-step hydrothermal method.
A macrocyclic 1,4-bis(4-pyridylethynyl)benzene showing unique aggregation-induced emission properties
Authors: Wang Zhaoyang , Bai Wei , Tong Jiaqi , Wang Yi Jia , Qin Anjun , Sun Jing Zhi , Tang Ben Zhong
Published: July 2016

A box-like macrocycle was constructed efficiently (60% yield). Because the intramolecular rotations are restricted by water clusters around the ionic moieties, the box shows unique aggregation-induced emission enhancement property.
Reactions in ultra-small droplets by tip-assisted chemistry
Authors: Guardingo M. , Busqué F. , Ruiz-Molina D.
Published: July 2016

In this feature article, we review the advances made in the deposition of femtolitre-sized droplets on surfaces using tip-assisted lithographic methods and their use as nanoreactors.
Functional group migrations between boron and metal centres within transition metal–borane and –boryl complexes and cleavage of H–H, E–H and E–E′ bonds
Authors: Owen Gareth R.
Published: July 2016

This review looks at the migration of functional groups between metal and boron centres and the activation of element–element bonds in transition metal–borane and –boryl complexes.
Estradiol-tethered micropatterned surfaces for the study of estrogenic non-genomic pathways
Authors: Qi B. , Shimizu Y. , Nakanishi J. , Winnik F. M.
Published: July 2016

Besides its hormonal effects, estradiol (E2) also activates non-nuclear pathways through interactions with receptors on the cell membrane.
Rapid protein immobilization for thin film continuous flow biocatalysis
Authors: Britton Joshua , Raston Colin L. , Weiss Gregory A.
Published: July 2016

Continuous flow biocatalysis gets a new spin. An efficient and general enzyme immobilization technique for vortex fluidic processing has been developed. The immobilized enzyme demonstrated no decrease in enzyme activity over 10 h in continuous flow with a >95% reduction in quantities of required reagents and enzymes.
CO2 capture enhancement in InOF-1 via the bottleneck effect of confined ethanol
Authors: Peralta Ricardo A. , Campos-Reales-Pineda Alberto , Pfeiffer Heriberto , Álvarez J. Raziel , Zárate J. Antonio , Balmaseda Jorge , González-Zamora Eduardo , Martínez Ana , Martínez-Otero Diego , Jancik Vojtech , Ibarra Ilich A.
Published: July 2016

Partial loading of the pores in InOF-1 with EtOH creates wide sections separated by “bottlenecks” and leads to 2.7-fold enhanced, kinetic experiment, CO2 capture.
Capturing neon – the first experimental structure of neon trapped within a metal–organic environment
Authors: Wood Peter A. , Sarjeant Amy A. , Yakovenko Andrey A. , Ward Suzanna C. , Groom Colin R.
Published: July 2016

Here we report the first experimental structure of neon captured within an organic or metal–organic crystalline environment.
An AIE-active fluorescence turn-on bioprobe mediated by hydrogen-bonding interaction for highly sensitive detection of hydrogen peroxide and glucose
Authors: Song Zhegang , Kwok Ryan T. K. , Ding Dan , Nie Han , Lam Jacky W. Y. , Liu Bin , Tang Ben Zhong
Published: July 2016

An AIE-active “turn-on” bioprobe is designed for hydrogen peroxide detection based on an imine-functionalized tetraphenylethene derivative.
Surface patterning of polyacrylamide gel using scanning electrochemical cell microscopy (SECCM)
Authors: Oseland Elizabeth E. , Ayres Zoë J. , Basile Andrew , Haddleton David M. , Wilson Paul , Unwin Patrick R.
Published: July 2016

Scanning electrochemical cell microscopy is introduced as a new tool for the synthesis and deposition of polymers on SAM-functionalised Au surfaces.
Novel in situ self-separation of a 2 in. free-standing m-plane GaN wafer from an m-plane sapphire substrate by HCl chemical reaction etching in hydride vapor-phase epitaxy
Authors: Woo Seohwi , Lee Sangil , Choi Uiho , Lee Hyunjae , Kim Minho , Han Jaiyong , Nam Okhyun
Published: July 2016

A 2 in.-diameter free-standing m-plane GaN wafer was fabricated through in situ self-separation from m-plane sapphire using HCl chemical reaction etching (HCRE) in hydride vapor-phase epitaxy (HVPE).
On the physical origins of interaction-induced vibrational (hyper)polarizabilities
Authors: Zaleśny Robert , Garcia-Borràs Marc , Góra Robert W. , Medved' Miroslav , Luis Josep M.
Published: July 2016

Our study presents the results of a pioneering exploration of the physical origins of vibrational contributions to the interaction-induced electric properties of molecular complexes.
Hetero-dinuclear complexes of 3d metals with a bridging dinitrogen ligand: theoretical prediction of the characteristic features of geometry and spin multiplicity
Authors: Nakagaki Masayuki , Sakaki Shigeyoshi
Published: July 2016

Spin multiplicities and coordination structures of dinitrogen-bridged hetero-dinuclear complexes of 3d metals, (μ-N2)[M1(AIP)][M2(AIP)] (AIPH = (Z)-1-amino-3-imino-prop-1-ene; M1, M2 = V(i) to Co(i)), were investigated using the CASPT2 method.
Spectroscopic and computational investigations on the origin of charge transfer between included neutral guest molecules and a functionalized anionic layered host
Authors: Dutta Dipak , Tummanapelli Anil Kumar
Published: July 2016

The nature and origin of charge-transfer as a driving force for the intercalation of neutral guests in the galleries of a functionalized anionic layered host are investigated.
Molecular dynamics simulation studies of hyperbranched polyglycerols and their encapsulation behaviors of small drug molecules
Authors: Yu Chunyang , Ma Li , Li Ke , Li Shanlong , Liu Yannan , Zhou Yongfeng , Yan Deyue
Published: July 2016

Computer simulation could disclose more details about the conformations of HPGs and their encapsulation behaviors of guest molecules.
Acetate ligands determine the crystal structure of CdSe nanoplatelets – a density functional theory study
Authors: Koster Rik S. , Fang Changming , van Blaaderen Alfons , Dijkstra Marjolein , van Huis Marijn A.
Published: July 2016

Density functional theory calculations show that acetate ligands play a crucial role in stabilising cadmium selenide nanoplatelets in the zinc blende crystal structure.
Photoswitchable azobenzene-appended iridium(iii) complexes
Authors: Pérez-Miqueo J. , Altube A. , García-Lecina E. , Tron A. , McClenaghan N. D. , Freixa Z.
Published: July 2016

The use of aliphatic-bridging units to append azobenzene fragments on triscyclometalated Ir(iii) complexes permits the construction of photoswitchable organometallics.
Functionalized phosphonates as building units for multi-dimensional homo- and heterometallic 3d–4f inorganic–organic hybrid-materials
Authors: Köhler C. , Rentschler E.
Published: July 2016

Using the multifunctional ligand H4L (2,2′-bipyridinyl-5,5′-diphosphonic acid), a new family of 0D-3D inorganic–organic hybrid-materials was prepared and characterized by single crystal diffraction and magnetic measurements.
Colour tuning by the stepwise synthesis of mononuclear and homo- and hetero-dinuclear platinum(ii) complexes using a zwitterionic quinonoid ligand
Authors: Kar Paramita , Yoshida Masaki , Kobayashi Atsushi , Routaboul Lucie , Braunstein Pierre , Kato Masako
Published: July 2016

The colour of a mononuclear Pt(ii) complex bearing a [O,N,N,O] quinonoid ligand is judiciously tuned by stepwise deprotonation and successive homo- and hetero-metalation.
The defect structure and chemical lattice strain of the double perovskites Sr2BMoO6−δ (B = Mg, Fe)
Authors: Tsvetkov D. S. , Ivanov I. L. , Malyshkin D. A. , Steparuk A. S. , Zuev A. Yu.
Published: July 2016

The defect structure of B-site ordered double perovskites Sr2BMoO6−δ was analyzed.
Engineering water dissociation sites in MoS2 nanosheets for accelerated electrocatalytic hydrogen production
Authors: Zhang Jian , Wang Tao , Liu Pan , Liu Shaohua , Dong Renhao , Zhuang Xiaodong , Chen Mingwei , Feng Xinliang
Published: July 2016

Engineering the water dissociation sites of MoS2 nanosheets can efficiently enhance the electrocatalytic hydrogen evolution under alkaline conditions.
Efficient perovskite solar cells by metal ion doping
Authors: Wang Jacob Tse-Wei , Wang Zhiping , Pathak Sandeep , Zhang Wei , deQuilettes Dane W. , Wisnivesky-Rocca-Rivarola Florencia , Huang Jian , Nayak Pabitra K. , Patel Jay B. , Mohd Yusof Hanis A. , Vaynzof Yana , Zhu Rui , Ramirez Ivan , Zhang Jin , Ducati Caterina , Grovenor Chris , Johnston Michael B. , Ginger David S. , Nicholas Robin J. , Snaith Henry J.
Published: July 2016

Realizing the theoretical limiting power conversion efficiency (PCE) in perovskite solar cells requires a better understanding and control over the fundamental loss processes occurring in the bulk of the perovskite layer and at the internal semiconductor interfaces in devices.
Structure engineering of filled protein microbeads to tailor release of oil droplets in gastric digestion
Authors: van Leusden P. , den Hartog G. J. M. , Bast A. , Postema M. , van der Linden E. , Sagis L. M. C.
Published: July 2016

Oil droplets, encapsulated in WPI protein microbeads, are released over different time scales and in different ways in a simulated gastric system. This release depends on the protein concentration, the way in which the protein matrix is gelled and whether the beads are freeze-dried.
Bilberry extract, its major polyphenolic compounds, and the soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells
Authors: Aichinger G. , Pahlke G. , Nagel L. J. , Berger W. , Marko D.
Published: July 2016

The soy isoflavone genistein, a bilberry extract as well as some of its polyphenolic compounds antagonize the cytostatic properties of Erlotinib (Tarceva®), a tyrosine kinase inhibiting chemotherapheutic drug.
Antioxidant activity in vitro and in vivo of the polysaccharides from different varieties of Auricularia auricula
Authors: Xu Siqi , Zhang Yongjun , Jiang Kan
Published: July 2016

In this study, five different kinds of polysaccharides (AAP1, AAP2, AAP3, AAP4, and AAP5) were extracted from different varieties ofAuricularia auriculathrough an alkali extraction process.
Selective synthesis of trisubstituted (trifluoromethyl)alkenes via ligand-free Cu-catalyzed syn hydroarylation, hydroalkenylation and hydroallylation of (trifluoromethyl)alkynes
Authors: Yamamoto Y. , Ohkubo E. , Shibuya M.
Published: July 2016

The Cu-catalyzed hydroarylation, hydroalkenylation, and hydroallylation of (trifluoromethyl)alkynes with organoboron reagents produced diverse (trifluoromethyl)alkenes.
An in vitro–in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells
Authors: Hagiwara M.
Published: July 2016

The mechanisms of 2D pattern formation in bronchial epithelial cells were dynamically analyzed by controlled cell culture and a reaction-diffusion model.
Structure and dynamics of H. pylori 98-10 C5-cytosine specific DNA methyltransferase in complex with S-adenosyl-l-methionine and DNA
Authors: Singh Swati , Tanneeru Karunakar , Guruprasad Lalitha
Published: July 2016

Binding of DNA methyltransferase M. Hpy C5mC, to cofactor AdoMet and substrate DNA revealed from MD simulations.
ICN: a normalization method for gene expression data considering the over-expression of informative genes
Authors: Cheng Lixin , Wang Xuan , Wong Pak-Kan , Lee Kwan-Yeung , Li Le , Xu Bin , Wang Dong , Leung Kwong-Sak
Published: July 2016

The global increase of gene expression has been frequently established in cancer microarray studies.
Biosynthesis-driven structure–activity relationship study of premonensin-derivatives
Authors: Ismail-Ali A. , Fansa E. K. , Pryk N. , Yahiaoui S. , Kushnir S. , Pflieger M. , Wittinghofer A. , Schulz F.
Published: July 2016

The controlled derivatization of natural products is of great importance for their use in drug discovery.
Identification of novel small-molecule inhibitors targeting menin–MLL interaction, repurposing the antidiarrheal loperamide
Authors: Yue Liyan , Du Juanjuan , Ye Fei , Chen Zhifeng , Li Lianchun , Lian Fulin , Zhang Bidong , Zhang Yuanyuan , Jiang Hualiang , Chen Kaixian , Li Yuanchao , Zhou Bing , Zhang Naixia , Yang Yaxi , Luo Cheng
Published: July 2016

Scaffold hopping combines with biochemical studies and medicinal chemistry optimizations, leading to potent inhibitors of the menin–MLL interaction.
Synthesis of esters via sp3 C–H functionalisation
Authors: Majji Ganesh , Rout Saroj K. , Rajamanickam Suresh , Guin Srimanta , Patel Bhisma K.
Published: July 2016

This review describes various methods for the synthesis of eleven classes of esters involving sp3 C–H functionalisation.
(IPr)CuF-catalyzed α-site regiocontrolled trans-hydrofluorination of ynamides
Authors: Zhu Guohao , Qiu Shineng , Xi Yang , Ding Yao , Zhang Dongming , Zhang Rong , He Guangke , Zhu Hongjun
Published: July 2016

Experimental results indicate that the regioselectivity of the reaction is unexpectedly opposite to observed in the (Ph3P)3CuF-catalyzed hydrofluorination of ynamides, and the resulting α-fluoro products allowed for the synthesis of α-fluoro imides through further transformations.
Elaboration of tetra-orthogonally-substituted aromatic scaffolds towards novel EGFR-kinase inhibitors
Authors: Close Adam J. , Jones Rhiannon N. , Ocasio Cory A. , Kemmitt Paul , Roe S. Mark , Spencer John
Published: July 2016

Tetrasubstituted aromatic scaffolds have been elaborated and a number of EGFR inhibitors have been synthesised and their activity rationalised by docking studies.
Solid solution Pb1−xEuxTe: constitution and thermoelectric behavior
Authors: Wang Xin-Ke , Veremchuk Igor , Bobnar Matej , Zhao Jing-Tai , Grin Yuri
Published: July 2016

The thermoelectric properties of polycrystalline materials on the basis of the solid solution Pb1−xEuxTe prepared by spark-plasma-sintering are characterized. The solid solution undergoes a metal–semiconductor transition in parallel to the p–n transition around 500 K.
Transforming inorganic layered montmorillonite into inorganic–organic hybrid materials for various applications: a brief overview
Authors: Varadwaj G. Bishwa Bidita , Parida Kulamani , Nyamori Vincent O.
Published: July 2016

The effects of various reaction parameters on the synthesis of silylated montmorillonites and several applications of these inorganic–organic layered materials are briefly overviewed in this review.
S-Nanoparticle/SDS: an efficient and recyclable catalytic system for synthesis of substituted 4H-pyrido[1,2-a]pyrimidines in aqueous admicellar medium
Authors: Sagir Hozeyfa , Rai Pragati , Neha Shamshun , Singh Prashant Kumar , Tiwari Shailendra , Siddiqui I. R.
Published: July 2016

A green protocol has been described for the synthesis of 4H-pyrido[1,2-a]pyrimidines under admicellar catalysis by S8 NPs.
In vivo angiogenesis in tissues penetrating into porous β-tricalcium phosphate scaffolds
Authors: Ma Chao , Wang Zhen , Lu Xiao , Lu Jian-Xi , Bai Feng , Wang Chao-Feng , Li Li , Hou Shu-Xun , Wang Hua-Dong
Published: July 2016

In vivo angiogenesis in a three-dimensional bone graft after the implantation of spherical porous β-tricalcium phosphate scaffolding materials into lumbodorsal fascia of New Zealand rabbits.
NiCo nanotubes plated on Pd seeds as a designed magnetically recollectable catalyst with high noble metal utilisation
Authors: Schaefer S. , Felix E.-M. , Muench F. , Antoni M. , Lohaus C. , Brötz J. , Kunz U. , Gärtner I. , Ensinger W.
Published: July 2016

The tailored structure of a bifunctional, semi-homogeneous NiCo-nanotube catalyst system with embedded Pd nanoparticles, is synthesised by electroless plating.
Can single graphene nanodisks be used as Raman enhancement platforms?
Authors: López-Carballeira Diego , Ramos-Berdullas Nicolás , Pérez-Juste Ignacio , Mandado Marcos
Published: July 2016

Small nanographene structures are promising for the development of SERS platforms at the frontier of nanometer and subnanometer scales.
Transport features and structural optimization of solid lipid nanoparticles crossing the intestinal epithelium
Authors: Chai Guihong , Meng Yufang , Chen Shaoqing , Hu Fuqiang , Gan Yong , Yuan Hong
Published: July 2016

In vitrosimulated intestinal epithelial cell monolayer is a novel avenue to screen optimal SLNs formulations.
Frustratingly synergic effect of cobalt–nickel heterometallic precatalysts on ethylene reactivity: the cobalt and its heteronickel complexes bearing 2-methyl-2,4-bis(6-aryliminopyridin-2-yl)-1H-1,5-benzodiazepines
Authors: Zhang Shu , Xing Qifeng , Sun Wen-Hua
Published: July 2016

The title complexes showed good activities toward ethylene reactivity when obtained oligomers followed a Poisson distribution, but the mononuclear cobalt complexes showed higher activities than the cobalt–nickel analogues.
RedOx-controlled sorption of iodine anions by hydrotalcite composites
Authors: Levitskaia Tatiana G. , Chatterjee Sayandev , Arey Bruce W. , Campbell Emily L. , Hong Yongchun , Kovarik Libor , Peterson James M. , Pence Natasha K. , Romero Jesus , Shutthanandan Vaithialingam , Schwenzer Birgit , Varga Tamas
Published: July 2016

Layered hydrotalcite materials containing redox active components activate two uptake mechanisms driven by ion exchange and the redox reactions, greatly enhancing affinity and selectivity toward anions of iodine.
Comparative study of the effect of swift heavy ion irradiation at 500 °C and annealing at 500 °C on implanted silicon carbide
Authors: Hlatshwayo T. T. , O'Connell J. H. , Skuratov V. A. , Wendler E. , Njoroge E. G. , Mlambo M. , Malherbe J. B.
Published: July 2016

TEM, RS and RBS were used to characterize polycrystalline SiC specimens individually implanted with 360 keV I+ or Kr+ ions at room temperature and thereafter either irradiated with 167 MeV Xe to a fluence of 5 × 1013 cm−2 at 500 °C or annealed at 500 °C under vacuum.
Exploring the structural relationship between encapsulated antimicrobial peptides and the bilayer membrane mimetic lipidic cubic phase: studies with gramicidin A′
Authors: Meikle Thomas G. , Conn Charlotte E. , Separovic Frances , Drummond Calum J.
Published: July 2016

Lipid based bicontinuous cubic mesophases provide a low-cost, robust membrane mimetic nanomaterial which allows for the incorporation of membrane peptides and proteins.
Solvent-polarity-tuned nanostructures assembled from modified octadecylcarbamate with an anthracen moiety
Authors: Zhang Yimeng , Xing Pengyao , Yang Minmin , Wang Yajie , Wang Bo , Hao Aiyou , Ma Mingfang
Published: July 2016

A-9-YMOC tends to form nanofibers whereas it self-assembles in polar solvents and nanoflowers in nonpolar solvents with different molecular arrangements.
Charge transfer plasmon resonances across silver–molecule–silver junctions: estimating the terahertz conductance of molecules at near-infrared frequencies
Authors: Wu Lin , Tan Shu Fen , Bosman Michel , Yang Joel K. W. , Nijhuis Christian A. , Bai Ping
Published: July 2016

Quantum plasmon resonances have been recently observed across molecular tunnel junctions. The present work extends these studies theoretically using a generalized space-charge corrected electromagnetic model for a wider range of molecules.
Computational study on gold-catalyzed (4 + 3) intramolecular cycloaddition of trienyne: mechanism, reactivity and selectivity
Authors: Li Meng-Ru , Wang Gui-Chang
Published: July 2016

The reaction mechanism, reactivity and selectivity of the Au(i)-catalyzed intramolecular (4 + 3) cycloaddition of trienyne have been studied by density functional theory (DFT) calculations.
Pinecone-like hierarchical anatase TiO2bonded with carbon enabling ultrahigh cycling rates for sodium storage
Authors: Chen Jun , Zou Guoqiang , Hou Hongshuai , Zhang Yan , Huang Zhaodong , Ji Xiaobo
Published: July 2016

Pinecone-like hierarchical anatase TiO2homogeneously tuned by using carbon through Ti–C bonds is proposed as a superior anode for Na-ion batteries featuring remarkable high-rate capabilities and cycling stabilities.
Carbon–boron core–shell microspheres for the oxygen reduction reaction
Authors: Periasamy Arun Prakash , Ravindranath Rini , Roy Prathik , Wu Wen-Ping , Chang Huan-Tsung , Veerakumar Pitchaimani , Liu Shang-Bin
Published: July 2016

Carbon nanomaterials (CNMs) with self-assembled carbon microspheres are prepared from red onion skins. The CNMs are further used to prepare carbon–boron core–shell CNMs, which provide high activity for the oxygen reduction reaction (ORR).
Simultaneous enhancement in the power factor and thermoelectric performance of copper sulfide by In2S3 doping
Authors: Meng Qing-Long , Kong Shuang , Huang Zhiwei , Zhu Yuanhu , Liu Heng-Chang , Lu Xiaowei , Jiang Peng , Bao Xinhe
Published: July 2016

Simultaneous enhancement in the power factor and thermoelectric performance of copper sulfide is realized by introducing In2S3, which will be beneficial to the practical application.
MnO modified carbon nanotubes as a sulfur host with enhanced performance in Li/S batteries
Authors: An Taihua , Deng Dingrong , Lei Ming , Wu Qi-Hui , Tian Zhaowu , Zheng Mingsen , Dong Quanfeng
Published: July 2016

MnO modified CNTs are applied as an efficient sulfur host to improve the performance of Li/S batteries due to the strong polysulfide adsorbability.
Fortified interpenetrating polymers – bacteria resistant coatings for medical devices
Authors: Venkateswaran Seshasailam , Henrique Dos Santos Orlando David , Scholefield Emma , Lilienkampf Annamaria , Gwynne Peter J. , Swann David G. , Dhaliwal Kevin , Gallagher Maurice P. , Bradley Mark
Published: July 2016

Nanocapsule-mediated eugenol release from an interpenetrating polymer network coating reduces bacterial binding on medical devices.
Aptamer-functionalized DNA microgels: a strategy towards selective anticancer therapeutic systems
Authors: Wang Yitong , Yan Miaomiao , Xu Lu , Zhao Wenrong , Wang Xiaolin , Dong Shuli , Hao Jingcheng
Published: July 2016

DNA microgels of oligonucleotides and polymers were constructed via a combination of DNA complementarity and photo-initiated free radical polymerization.