bluuebunny/crossref_metadata_2025 huggingface dataset:
An approach to identification and forensic analysis of DNS attacks
Authors: Sousa Robson Everton , Vale Samyr
Published: July 2023

Domain name resolution servers (DNS) perform a key function in establishing access to web pages. Because of their importance, they are constant targets for cyber-attacks, which aim to erase or replace some of their records, causing huge losses for users, companies and institutions worldwide. In Brazil, to prevent such attacks, a legal provision is established that criminally typifies the invasion of computer devices connected to the World Wide Web, which includes attacks on the DNS service. Still, cyber-attack identification is difficult as it depends on the correct application of means of protection, monitoring of network services and extraction and interpretation of data that allow the identification of criminal factors. The present work proposes a computational forensics approach to automatically detect the occurrence of a DNS cache poisoning attack, subsuming the elements that constitute the attack to the legal device, thus identifying the occurrence of a crime.
ТЕХНОЛОГІЯ ВИКОРИСТАННЯ МОДЕЛІ ДЕРЖАВНО- ПРИВАТНОГО ПАРТНЕРСТВА В ПРОФЕСІЙНІЙ ОСВІТІ
Authors: Рябова Зоя
Published: July 2023

The introduction of public-private partnership into the professional education system is due to a number of factors. In particular, seven factors have been identified. An appropriate model is being created for the implementation of public-private partnership inprofessional education. For its implementation in the practice of professional (vocational and technical) education institutions, a technology is being developed that guarantees obtaining the planned result.
ДЕРЖАВНО-ПРИВАТНЕ ПАРТНЕРСТВО КРІЗЬ ПРИЗМУ ДУАЛЬНОЇ ОСВІТИ
Authors: Сидій Надія
Published: July 2023

Проаналізовано основні вимоги до розвитку системипрофесійної (професійно-технічної) освіти в сучасних умовах. Висвітлено вітчизняний та закордонний досвід державно-приватного партнерства у професійній освіті. Охарактеризовано роль дуальної освіти, певні досягнення та проблеми, які виникають під час реалізації проєктів державно-приватного партнерства в системі професійної освіти і підготовки.
Niclosamide Substance: Modification, Analysis, and Biological Activity
Authors:   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Khalikov S. S. , Godovikov I. A. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Lokshin B. V. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Pak A. M. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Khakina E. A. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia,   National Research University Higher School of Economics, ul. Vavilova 7, Moscow, 101000 Russia, Babaskina M. M. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia,   National Research University Higher School of Economics, ul. Vavilova 7, Moscow, 101000 Russia, Ilyin M. M. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Anikina L. V. ,   Institute of Physiologically Active Substances, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow Oblast, 142432 Russia
Published: July 2023

The niclosamide substance (NCS) is a part of many anthelmintic and anticancer drugs. However, it has a serious drawback—the low solubility in water and physiologically active media, which leads to the high dosage required to achieve a therapeutic effect, increased cost, and enhanced toxicity. To improve the solubility of NCS, its mechanochemical modification with polymers has been suggested. This allows for increasing the solubility of NCS in 40–52 times. Such an increase in this parameter is shown not to affect the cytotoxic activity adequately. The observed selectivity towards different cancer cell cultures is discussed.
Executive Compensation and Value of Listed Deposit Money Banks in Nigeria
Authors: Barde Ibrahim Magaji , Kantudu Aliyu Suleiman , Dandago Kabiru Isa , Jalingo Ummu Ahmed , Zik-Rullahi Ahmed Abubakar , Yusuf Abubakar , Maigoshi Zaharaddeen Salisu , Gololo Ibrahim Aliyu , Suleiman Bashir Ali
Published: July 2023

The increasing failure of banks has made it important to seek for ways to enhance its value in order to attract investors and potential investors. To make this reality, scholars have argued from various quarters that the people who manage the banks must be adequately compensated if the desired value needs to be achieved. Therefore, the study examines the relationship between executive compensation and value of listed deposit money banks (DMB) in Nigeria. The study adopted correlational research design with balanced panel data of 14 listed banks which served as population of the study for the period of 2010-2021 using Generalized Least Square (GLS) regression as a tool of analysis. The study found that CEO Pay and Chairman’s compensation have positive effect on the value of listed banks, while the highest paid director exact negative influence on the banks’ value. This implies that the CEO Pay and Chairman’s compensation improves the value of banks. Therefore, it is recommended among others that the management of banks should increase the CEO pay and place more emphasis on performance as a basis of increased pay to guarantee continuous improvement in the value of the banks.
Identifikasi Mikroplastik pada Air, Sedimen, dan Ikan Nila (Oreochromis niloticus) di Sungai Porong, Kabupaten Sidoarjo, Jawa Timur
Authors: Seftianingrum Bella , Hidayati Irul , Zummah Atiqoh
Published: July 2023

Kondisi perairan Indonesia saat ini sangat terancam pencemaran mikroplastik, baik itu air laut meupun air tawar. Adanya cemaran mikroplastik di badan perairan dapat menyebabkan gangguan fisiologi organisme yang hidup diperairan tersebut. Oleh karena itu, penelitian ini dilakukan untuk mengetahui kelimpahan mikroplastik di air, sedimen, dan ikan nila (Oreochromis niloticus) sepanjang hulu, tengah, dan hilir Sungai Porong di Kabupaten Sidoarjo serta menguji bentuk, warna, dan jenis polimer mikroplastik tersebut. Penelitian ini dilakukan dengan metode observasional analitik tanpa melibatkan intervensi pada subjek penelitian, dengan pendekatan retrospektif. Hasil penelitian menunjukkan bahwa Sungai Porong di Kabupaten Sidoarjo, Jawa Timur tercemar oleh mikroplastik, baik pada air, sedimen, maupun organisme (ikan). Bentuk yang paling umum adalah fiber dan warna yang ditemukan adalah hitam, merah, biru, kuning, dan putih. Hasil uji FTIR ATR menunjukkan bahwa mikroplastik yang ditemukan terbuat dari jenis polimer Polymethyl methacrylate acrylic (PMMA), High Density Polyethylene (HDPE), Cellulose Acetate (CA), dan Polyethylene terephthalate (PET). Oleh karena itu, perlu tindakan untuk mengurangi dampak mikroplastik pada lingkungan, seperti dengan mengurangi penggunaan plastik sekali pakai dan meningkatkan sistem pengolahan limbah yang lebih baik.
Migraciones, deportes y comunidades. El papel del deporte en la articulación de las comunidades migrantes mexicanas en Estados Unidos
Authors: Escala Rabadán Luis
Published: July 2023

En miles de localidades en todo el mundo, millones de personas se ven obligadas a emigrar por razones políticas, económicas, por la violencia o por desastres naturales. Posteriormente, estos migrantes buscarán la rearticulación de sus comunidades en los lugares de llegada, a través de diversos procesos, con resultados contingentes. En este artículo, documentamos y examinamos el papel de la práctica deportiva como uno de los procesos de reconfiguración de las comunidades migrantes en sus lugares de destino. Si bien la eventual formación de comunidades migrantes se puede explicar a partir de la inserción de las y los migrantes en nichos laborales, para lo cual se despliegan las redes sociales que se articulan en buena medida con base en los vínculos de distintos tipos, el papel de elementos socio-culturales como la práctica deportiva se convierten en factores importantes que facilitan y consolidan este proceso de reagrupamiento comunitario frente a la dispersión impuesta por los procesos laborales en el Norte global. Asimismo, dicha práctica deportiva se constituye en un vehículo que facilita la inserción de los propios migrantes en sus nuevos entornos de llegada. Para ello, utilizamos el caso de la práctica del fútbol y el básquetbol entre migrantes mexicanos en California, Estados Unidos. Concluimos señalando la importancia de este tipo de elementos como factor para explicar no solamente la congregación de migrantes, sino también y sobre todo el surgimiento de procesos de identificación que hacen posible el surgimiento de verdaderas comunidades migrantes, y con ello poderse reconocer más allá del sentido impuesto de fuerza laboral transnacional.
Mundial 2022: “Francia colabora en la operación de propaganda de una teocracia islámica retrógrada”
Authors: Ollier Fabien
Published: July 2023

Considerando que la invasión de Ucrania, dirigida por el ejército ruso y sus diversas tropas auxiliares, constituye una amenaza inmediata para la paz en toda Europa y que Putin acentúa día a día su política genocida que pretende erradicar del mapa a un pueblo soberano multiplicando los crímenes contra la humanidad y crimenes de guerra (destrucción masiva de ciudades e instalaciones civiles, torturas, violaciones, ejecuciones sumarias y fosas comunes, desplazamiento forzado de poblaciones, anexiones, rusificación), las cámaras y comentarios de todo el mundo apuntan al “evento planetario”: la Copa del Mundo en Qatar. La afición del "planeta fútbol", al unísono con casi todos los medios de comunicación públicos o privados, todavía se atreve a presentar el Mundial como "un factor de entendimiento entre los pueblos", una "fiesta de la juventud", un "encuentro unificador deportivo" y otros manidos lemas de "paz deportiva" que emergen regularmente como mantras de la burocracia rectora de la FIFA, lastrada durante años por graves casos de corrupción. Las escandalosas declaraciones de su presidente, Gianni Infantino, que se opone a cualquier forma de solidaridad con las mujeres, jóvenes y demócratas víctimas de la sangrienta represión del régimen islámico de los ayatolás en Irán y que defiende servilmente a Qatar, dan la medida de en lo que se ha convertido la FIFA: una cínica mafia empresarial.
PENGEMBANGAN PLATFORM MATERIMU BERBASIS WEBSITE MENGGUNAKAN CMS SEBAGAI SUMBER BELAJAR DALAM MATA PELAJARAN KOMPUTER DAN JARINGAN DASAR SISWA KELAS X TKJ SMK MUHAMMADIYAH 2 KUNINGAN
Authors: Tria Sutriana  , Ipan Ripai
Published: July 2023

Sekolah Menengah Kejuruan (SMK) merupakan salah satu bentuk satuan pendidikan formal yang menyelenggarakan pendidikan pendidikan kejuruan pada jenjang pendidikan menengah, SMK ini mencetak siswa/siswi nya agar memiliki skil dan kemampuan yang dapat bersaing di dunia kerja dan dalam peroses belajar mengajar para guru maupun siswa belum bisa memaksimalkan penggunaan Internet terutama website maka perlu ada inovasi sumber belajar yang dapat menunjang itu semua. Tujuan dari penelitian ini : (1) mengembangkan platform materimu berbasis website (2) mengetahui kelayakan platform materimu (3) untuk mengetahui respon kelas X TKJ SMK Muhammadiyah 2 Kuningan. Hasil Penelitian ini adalah : penelitian ini menggunakan CMS Wordpress. Pengumpulan data menggunakan pedoman wawancara, observasi dan angket. Penelitian ini menggunakan metode Penelitan Research & Development (R&D) menggunakan model ADDIE. (2) uji kelayakan produk dilakukan dalam 2 tahap yaitu uji alpha dan uji beta. Uji alpha dilakukan oleh 2 orang ahli media dan ahli materi kemudian uji beta dilakukan kepada 25 orang terdiri dari 12 orang laki-laki dan 13 orang perempuan siswa/siswi SMK Muhammadiyah 2 Kuningan. Hasil dari penelitian ini adalah 84,5% dengan kategori Sangat Layak. (3) respon siswa mengenai platform materimu ini sangat baik karna mereka terbantu dalam peroses belajar dengan adanya inovasi sumber belajar.
La polisensibilización y la intensidad de sensibilización, como factores de riesgo en el asma grave
Authors: Perdomo Pulido Yusely , Torres Hernández Alexander , Morales Valdés Juan Carlos
Published: July 2023

Introducción: El manejo del asma tiene entre sus objetivos el control de los síntomas y de los factores de riesgo. El 20% de los pacientes adultos y menos del 5% de los niños con asma, sufren de un asma grave. Las pruebas cutáneas por punción forman parte del diagnóstico etiológico de esta enfermedad. La polisensibilización y la intensidad de la sensibilización de los pacientes asmáticos son elementos para evaluar en las pruebas cutáneas por punción. Objetivo: identificar en la bibliografía consultada si la polisensibilización y la intensidad de la sensibilización, evaluadas a través de pruebas cutáneas por punción, utilizando extractos de ácaros, se consideraban factores de riesgo en el desarrollo del asma grave. Metodología: se realizó una búsqueda bibliográfica en las revistas relacionadas con el tema a investigar, durante el año 2020, se seleccionaron las revistas que se encontraban al momento del estudio en los 50 primeros puestos del ranking scimago. Resultados: en los artículos revisados no se describe la polisensibilización y a la intensidad de la sensibilización como factores de riesgo en el asma grave, pero si hacen referencia a los ácaros del polvo como factor de riesgo relacionados con la severidad de síntomas y como factor desencadenante de las reacciones alérgicas en pacientes asmáticos. Conclusión: existe un vacío en el conocimiento con respecto al tema a investigar.
Laparoscopic TAPP Inguinal Hernia Repair: Mesh Fixation & Peritoneal Closure by Sutural Technique
Authors: Bhuiyan Md Jahangir Hossan , Begum Farhana , Alam Md Mazharul , Parveen Urmee
Published: July 2023

Background: The laparoscopic transabdominal preperitoneal (TAPP) inguinal repair is an evolving technique associated with well-known advantages of a minimally invasive approach. This prospective study was conducted to evaluate the feasibility, safety and effectiveness of laparoscopic TAPP using sutural mesh fixation & peritoneal closure. Intracorporeal sutural technique needs steep learning curve.
Methods: Between May 2018 to December 2019, a total of 41 inguinal hernias underwent TAPP repair in 37 adults under general anesthesia. All the patients scheduled for elective inguinal hernia repair were offered the choice of the laparoscopic TAPP repair under general anesthesia. A detailed explanation of the procedure was given to all patients and informed consent was obtained. We used 2/0 vicryl for mesh fixation & peritoneal closure which took only 6.80 US Dollar in comparison to Protack from Covidien which is 167.80 US Dollar. Intraoperative & postoperative variables were recorded in pre structured proforma.
Results: The 41 hernia includes 34(82.92%) direct, 07(17.08%) indirect. Unilateral hernia were 33(89.19%), & bilateral were 4(10.81%). Mean operating time for unilateral cases was 122 minutes & for bilateral 210 minutes. Mean operating time in the cases using 3D-4K image system was 70 minutes. Mean duration of hospital stay was 2.9 days. There was no conversion in this study. Postoperative complications included scrotal seroma 2(5.40%), hematoma 1(2.70%), port site infection 2(5.40%) & mesh infection 1(2.70%). Assessment of intensity of postoperative pain was evaluated according to VAS. 05 patients complained of mild pain: pain on the visual analog score (VAS) = 1-3 during one month follow-up. No patient reported with chronic pain & recurrence during the followup period.
Conclusion: TAPP inguinal hernia repair with sutural mesh fixation & peritoneal closure is a feasible & safe technique with minimum postoperative morbidity and maximum patient’s satisfaction.
J Bangladesh Coll Phys Surg 2023; 41: 187-192
Procalcitonin as a Sepsis Marker in Patients of Critical Care Unit
Authors: Jasmine Rezina , Giti Susane , Khan Arif Ahmed , Jubaida Nishat , Naznin Lubna
Published: July 2023

Introduction: The aim of this study was to observe the diagnostic role of procalcitonin to evaluate sepsis and assess the level of inflammation for the patients of Critical Care Unit of different departments.
Methods: This cross sectional, prospective and observational study was conducted at Armed Forces Institute of Pathology on the patients at Critical Care Unit of Paediatric, Surgery, Gynae and Medicine department in a tertiary care hospital (Combined Military Hospital, Dhaka) from June, 2020 to May, 2021. Total 106 patients were enrolled in this study. As the study was conducted during corona pandemic, RT-PCR test for Corona virus disease 2019 (COVID-19) along with serum procalcitonin and bacterial culture and sensitivity tests for different samples were prescribed for all 106 patients.
Result: Out of 106 patients, 30.2% (32) patients were found positive and 69.69% (74) were found negative for COVID- 19 and 14.15% (15) patients had clinical documentation of bacterial co-infection, confirmed by blood, respiratory, or urine culture. After PCT test, 20.75 % (22) samples were found with severe sepsis or septic shock, 7.54% (08) samples were found with systemic infection, 18.06% (20) samples were with possible systemic infection, 31.13 % (33) samples were with local infections and 21.69% (23) were found within normal ranges of PCT.
Conclusion: This study supports the importance of the diagnostic role of PCT to assess the level of sepsis as well as presence of co-infection which suggests that PCT level is a good biomarker for early diagnosis, assessment and treatment of patients in CCU.
J Bangladesh Coll Phys Surg 2023; 41: 198-204
Clinicodemographic Characteristics of COVID-19 Infection Among Patients with Rheumatic Diseases
Authors: Ferdous Nira , Islam Md Nazrul , Rahman Mahfil Ara , Anjum Naziya , Zaman Ashik Uz , Nazrul Fahid Bin
Published: July 2023

Background: The occurrence of COVID-19 infection in rheumatic patients and their evaluation are of global interest. The purpose of this study was to determine the clinicodemographiccharacteristics of COVID-19 infection among rheumatic patients.
Methods: In this observational cross-sectional study, 167 consecutive patients of both genders from online consultancy were enrolled from 13th June to 12thOctober 2020 conducted in a tertiary level rheumatology consultation center, Modern One Stop Arthritis Care & Research Center®, Dhanmondi, Dhaka. The WHO case definition of COVID-19 and disease severity scoring tool were used for diagnosis and assessment of the patients.Suspected cases were interviewed in detail and investigated with RT-PCR for COVID-19, HRCT of the chest, X-ray chest P/A view, and other necessary tests. The prevalence of COVID-19 infection was expressed in percentage.
Results: Out of 167 rheumatic subjects,64 and 103 were men and women respectively, witha mean age of 42.15±13.04 years. The prevalence of COVID-19 infection was 7.78% (13/167). RT-PCR was positive in 9 (69.23%) patients and the remaining weresuspected cases (RT-PCR was negative but positive clinical features and X-ray chest findings.All COVID-19 positive patients presented with fever (100%).Among COVID-19 cases,spondyloarthritis (SpA), osteoarthritis of knee(OA),psoriatic arthrtis (PsA), rheumatoid arthritis (RA) and systemic lupus erythematosus(SLE)were5 (38.46%), 3 (23.08%), 2 (15.38%), 2 (15.38%) and 1 (7.69%) respectively.DMARDs/biologics wereongoingin 3 (tofacitinib), 1 (etanercept), 1 (methotrexate), 1 (sulphasalazine), 1(hydroxychloroquine) and 1 (leflunomide) patients.The use of non-specific drugs for Covid-19 treatment were azithromycin, ivermectin, doxycycline, and hydroxychloroquin. Among these rheumatic patients, the elderly group of patients with the comorbidities like diabetes5 (38.46%), hypertension 5 (38.46%)and bronchial asthma 3 (23.08%)were infected with COVID-19.
Conclusion: The prevalence of COVID-19 was 7.78% among the rheumatic patients. Fever was the universal presentation in this study. The commonest rheumatic diseases were SpA . Diabetes and hypertension werethe most common comorbidities in patients with rheumatic diseases with COVID-19 infection.
J Bangladesh Coll Phys Surg 2023; 41: 205-211
Tolosa Hunt Syndrome- A Case Report
Authors: Mahmood Shagufta , Alam Shah
Published: July 2023

Tolosa Hunt syndrome is a rare disorder of uncertain aetiology characterized by severe periorbital headaches and recurrent painful unilateral opthalmoplegia. Resolution of findings on follow-up imaging and response to steroids is characteristic. This case is to emphasize the role of MRI in the diagnosis of this condition.
J Bangladesh Coll Phys Surg 2023; 41: 234-236
Assessment of Psychiatric Morbidity Among Health Care Workers During COVID-19 Pandemic in A Tertiary Care Hospital in Bangladesh
Authors: Ahmmad Julhash Uddin , Shams S M Khalid , Hassan Nazmul , Miah Md Titu , Islam Md Azizul , Ahmed Md Sharif
Published: July 2023

Introduction: Assessment of the symptoms of anxiety, depression, stress and feeling of wellbeing among healthcare workers are essential to take necessary steps to treat or prevent any psychiatric morbidity.
Objective: The objective of the study was to assess the psychiatric morbidity among the healthcare workers of a tertiary level hospital in Bangladesh.
Methods: This was a cross sectional study conducted in Combined Military Hospital, Bogura, Bangladesh from July 2021 to December 2021. For this purpose, 50 health workers fulfilling inclusion and exclusion criteria were taken as sample. They filled up personal & sociodemographic data and the short-form Bangla version of WHO-5, GAD-7, PHQ- 9andPSS-5 scale [1,2,3,4,18]. The results showed that the mean age of the health workers was average 25 years with male predominance (58%). Symptoms of anxiety, depression, stress and wellbeing were found among 20%, 30% ,96% and 96% of health workers respectively. This excess stress and low feeling of wellbeing may be related to extra stressors caused by dread, fear and exceptional longevity of the disease itself and sudden socioeconomic drift down compounded by Covid-19 pandemic effects. Combination of depression, anxiety and stress in different patterns were also higher in them.
Conclusions: Incidence of psychiatric illness was high among health care workers during the COVID-19 pandemic. Further larger studies are required to categories these illness and to find out help to overcome.
J Bangladesh Coll Phys Surg 2023; 41: 212-218
Procalcitonin as a Marker of Bacterial Sepsis: Time for a Reappraisal?
Authors: Ahmed Mohiuddin
Published: July 2023

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection.1 It is frequently leading to death from septic shock and multi organ failure worldwide. Sepsis can be caused by any infection, either fungal, viral, parasitic, or bacterial, and not all of these pathogens can be cultured. In around half of patients with sepsis, no pathogen is identified.2 For every hour delayed treatment the risk of mortality from sepsis increases by 4-9%.3 Sepsis takes 11 million lives around the world each year, contributing to 20% of all deaths globally and taking more lives than cancer.4 There is more than 20 deaths every minute.5 Before the onset of organ dysfunction, infections should be identified and this requires a rapid diagnosis and a prompt initiation of treatment.
J Bangladesh Coll Phys Surg 2023; 41:183-184
Il Rene Artificiale: Aspetti Ingegneristici
Authors: Frigato Gianni
Published: July 2023

Abstract non disponibile
Le Linee Della Dialisi
Authors: Rossi Enea
Published: July 2023

Abstract non disponibile
L'emodialisi Senza Eparina
Authors: Bonomini Mario , Di Paolo Bruno , Albertazzi Alberto
Published: July 2023

Abstract non disponibile
La Monitorizzazione Della Conducibilità Elettrica Della Soluzione di dialisi
Authors: Sanna G.
Published: July 2023

Abstract non disponibile
L'eritropoietina Nell'insufficienza Renale: Recenti Acquisizioni e Modalità di Terapia
Authors: Leardi A. , Paoletti E. , Molinelli G.
Published: July 2023

Abstract non disponibile
Il Ruolo Del Monitoraggio Ambulatoriale Continuo Della Pressione Arteriosa Nei Dializzati
Authors: Timio M.
Published: July 2023

Abstract non disponibile
Dialisi Ultrabreve: Esperienza Del Centro Dialisi Dell'ospedale S. Paolo di Milano
Authors: Nardacchione G.
Published: July 2023

Abstract non disponibile
L'emergenza Cutanea Del Catetere in Dialisi Peritoneale
Authors: Cancarini G.C.
Published: July 2023

Abstract non disponibile
Nefropatia Da Abuso Di Analgesici: Una Malattia Evitabile
Authors: Zoni U.
Published: July 2023

Abstract non disponibile
Restless Leg Syndrome Nel Paziente Uremico
Authors: Savica V. , De Domenico P. , Musolino R. , Silvestri R. , Labate C. , Bellinghieri G.
Published: July 2023

Abstract non disponibile
Sistemi Anticoagulanti in Circolazione Extracorporea
Authors: Nordio M. , Marchini P. , Saporiti E.
Published: July 2023

Abstract non disponibile
Valutazione Del Peso Secco Del Paziente in Dialisi
Authors: Canino F.
Published: July 2023

Abstract non disponibile
Principi Fisici Dell'ultrasonografia e Criteri Topografici in Ecografia Renale
Authors: Meola M. , Buoncristiani E. , Cupisti A. , Cozza V. , Bartotti G.
Published: July 2023

Abstract non disponibile
Soluzioni per Dialisi Peritoneale: Sono Biocompatibili?
Authors: Cancarini G. C.
Published: July 2023

Abstract non disponibile
Presentazione
Authors: Di Paolo Nicola
Published: July 2023

Abstract non disponibile
Il Parere Del Tecnico Di Nefrologia
Authors: Enzo Giannoni , Nicola Tito , Mirko Cappelli , Saverio Pratelli , Federica Beltrami , Cecilia Vettori , Daniele Giannerini
Published: July 2023

Abstract non disponibile
Dietoterapia nell'insufficienza renale necessitante trattamento sostitutivo
Authors: Gentile M.G.
Published: July 2023

Abstract non disponibile
Alterazioni Ormonali Dell'insufficienza Renale Cronica
Authors: Bianchi M.L. , Ballerini L. , Cresseri D. , Buccianti G.
Published: July 2023

Abstract non disponibile
Il Caso Clinico
Authors: Garosi G.
Published: July 2023

Abstract non disponibile
La Valutazione Dell'efficienza Della Dialisi Peritoneale
Authors: Enia G.
Published: July 2023

Abstract non disponibile
Ruolo Della Terapia Dietetica Nella Sindrome Nefrosica
Authors: Gentile M.G.
Published: July 2023

Abstract non disponibile
Anaemia of Chronic Kidney Disease: Aligning Patient and Physician Awareness – Interviews with Three Key Opinion Leaders and Patient Advocates
Authors: George Juliet
Published: July 2023

Anaemia is a common and serious complication of chronic kidney disease (CKD) that can greatly impact the daily lives of patients. However, poor awareness around anaemia of CKD (aCKD), from both physicians and patients, may impede its identification and treatment. During interviews conducted by EMJ in April 2023, leading nephrologist Christoph Wanner, University Hospital of Würzburg, Germany, and two patients/patient advocates, Daniel Gallego and Jemma Reast, gave their informed opinions on this topic. From their different viewpoints, they described how greater understanding of symptoms and treatment options could empower patients to make better choices for their own care. At the same time, they considered how greater physician awareness of aCKD, and the human impact beyond haemoglobin levels could influence diagnosis and treatment priorities. Aligning these two perspectives, they also discussed the powerful benefits of improved communication and shared decision-making between patient and physician, and its potential for relieving the burden of aCKD.
Deceased Donor Transplantation: Patient Selection, Ethics, and New Approaches
Authors: Richards Darcy
Published: July 2023

RENAL transplantation was a hot topic at the 60th European Renal Association (ERA) Congress 2023, which took place both virtually and in-person in Milan, Italy, between 15th–18th June. One such session saw experts in transplant medicine, surgery, and transplant ethics deliver presentations on deceased donor kidney transplantation. Co-chaired by Marta Crespo, Hospital del Mar, Barcelona, Spain, and Christophe Mariat, University Hospital Saint-Étienne, Saint-Priest-en-Jarez, France, this symposium delivered invaluable insights into donor selection, transplant ethics, and approaches to improve graft viability and implementation.
Methodology for the development of management plans of nature-reserved territories
Authors: Shershun M. , Mykytyn T.
Published: July 2023

In Ukraine, the formation of the Emerald Network, which consists of special nature conservation areas, is underway. According to the resolutions and recommendations of the EU, a management plan must be developed for the objects of the Emerald Network, which will define both short-term and long-term management goals and ways to achieve them. Ukraine is developing a legislative framework for the objects of the Emerald Network. The definition of a management plan proposed by various authors for protected areas is given. It is proposed to consider a management plan as a document that implements the development strategy of a nature reserve object with specified projects and determined financial resources that will ensure their implementation. The advantages of having management plans and the requirements for their development are outlined. An author’s approach to the development of management plans is proposed, the stages of its construction are defined. Projects for the organization of the park territory are being developed for protected objects, in particular national natural parks in Ukraine. A comparative analysis of  management plans and projects of the organization was carried out. Proposals on the use of management plans in the work of nature protection institutions of Ukraine have been developed.
FINS DO HOMEM SEGUNDO JACQUES DERRIDA
Authors: Negris Adriano , José Derzi Moraes Marcelo
Published: July 2023

O presente artigo tem como objetivo apresentar a viabilidade de desconstrução do pensamento humanista, sob a perspectiva do filósofo franco-argelino Jacques Derrida. A partir dessa leitura derridiana poderemos vislumbrar não só a constituição metafísica que organiza os conceitos de homem e do humanismo, mas também entender como Derrida acena para a possibilidade de uma abertura para se pensar um deslocamento daquilo que o pensador franco-argelino chamou de “nós-os-homens”.
The fate of extra centrosomes in newly formed tetraploid cells: should I stay, or should I go?
Authors: Bloomfield Mathew , Cimini Daniela
Published: July 2023

An increase in centrosome number is commonly observed in cancer cells, but the role centrosome amplification plays along with how and when it occurs during cancer development is unclear. One mechanism for generating cancer cells with extra centrosomes is whole genome doubling (WGD), an event that occurs in over 30% of human cancers and is associated with poor survival. Newly formed tetraploid cells can acquire extra centrosomes during WGD, and a generally accepted model proposes that centrosome amplification in tetraploid cells promotes cancer progression by generating aneuploidy and chromosomal instability. Recent findings, however, indicate that newly formed tetraploid cells in vitro lose their extra centrosomes to prevent multipolar cell divisions. Rather than persistent centrosome amplification, this evidence raises the possibility that it may be advantageous for tetraploid cells to initially restore centrosome number homeostasis and for a fraction of the population to reacquire additional centrosomes in the later stages of cancer evolution. In this review, we explore the different evolutionary paths available to newly formed tetraploid cells, their effects on centrosome and chromosome number distribution in daughter cells, and their probabilities of long-term survival. We then discuss the mechanisms that may alter centrosome and chromosome numbers in tetraploid cells and their relevance to cancer progression following WGD.
Chemical compounds associated with increased risk for cancer incidence found in environmental samples obtained from two fire departments
Authors: Williams Denise N. , El Hay Florencia , Wijesinghe Arav , Pulluri Shynitha , Sturdivant Rodney X. , Barr Kelli L. , Harris Debra D.
Published: July 2023

Firefighters are exposed to many different biological and chemical contaminants while conducting their work duties, including polyaromatic hydrocarbons or PAHs. PAH compounds are of particular interest in investigations of firefighter health as they have been linked to detrimental health outcomes, including respiratory illnesses and cancers, and are found in high concentrations after fires. Thus, they are quantified in several studies on the occupational exposure of firefighters, and they are the focus of several protocols and technologies aiming to mitigate occupational exposures. Fire departments use standard operation protocols for limiting exposure to occupational health hazards, including exposure to chemical compounds such as PAHs. However, observations of firefighter workflows reveal the potential for major contamination of fire station work-live areas. Herein we make an initial report on the PAHs that firefighters continue to be exposed to after they have finished responding to calls and have potentially doffed their protective gear. The sampling of environmental surfaces in fire apparatus and stations was used as data. This study found that PAHs identified on turnout gear were found in the fire station, suggesting that turnout gear may be vectors of toxic chemicals. Therefore, protocols for decontamination of turnout gear and fire stations should be evaluated to remove PAHs and other chemicals known to impair health. This and further surface sampling studies are needed to better understand the full occupational exposures of firefighters to hazardous chemicals.
Acute gastrointestinal injury and altered gut microbiota are related to sepsis-induced cholestasis in patients with intra-abdominal infection: a retrospective and prospective observational study
Authors: Zhang Beiyuan , Chen Xiancheng , He Chenhang , Su Ting , Cao Ke , Li Xiaoyao , Duan Jianfeng , Chen Ming , Zhu Zhanghua , Yu Wenkui
Published: July 2023

Background

Sepsis-associated liver dysfunction (SALD) has high incidence and mortality in patients with intra-abdominal infection (IAI). The associations between acute gastrointestinal injury (AGI), gut microbiota, and SALD were evaluated in patients with IAI.

Methods

A retrospective study was conducted to assess the relationship between AGI and SALD in patients with IAI. Patients were divided into non-SALD and sepsis-induced cholestasis (SIC) groups, which is a subtype of SALD. SIC was defined as total bilirubin >2 mg/dL. AGI incidences between the two groups were compared using Chi-square test. Subsequently, a prospective study was conducted to investigate the gut microbiota differences between patients without SALD and those with SIC. Fecal samples were collected on days 1, 3, and 7 after admission to analyze changes in gut microbiota using 16S ribosomal ribonucleic acid sequencing.

Results

One hundred thirty-four patients with IAI were included retrospectively, with 77 SALD and 57 non-SALD cases. Among patients with SALD, 71 were diagnosed with SIC. Patients with SIC had a higher incidence of AGI compared to those without SALD (28.07% vs. 56.34%, p < 0.05), and a severity-dependent relationship was found between AGI grade and SIC occurrence. Subsequently, 20 patients with IAI were recruited prospectively, with 10 patients each assigned to the non-SALD and SIC groups. Patients with SIC had a more severe gut microbiota disorder on day 7 than those without SALD, including lower microbiota diversities, decreased abundance of Firmicutes and Bacteroidetes, and increased abundance of Proteobacteria and Actinobacteria at the phylum level. Furthermore, Burkholderia − Caballeronia − Paraburkholderia and Delftia, the two most abundant genera, were significantly higher in the SIC group than in the non-SALD group. Functional prediction analysis showed that the top three KEGG pathways were ribosome, pyrimidine metabolism, and the two-component system. During the first week, the abundance of Proteobacteria decreased significantly, whereas Cyanobacteria increased in the non-SALD group; however, the phyla taxa did not change significantly in the SIC group.

Conclusion

There exists a severity-dependent relationship between AGI grade and SIC occurrence in adult patients with IAI. A severe gut microbiota disorder was discovered in SIC during the first week of the intensive care unit stay.
Analysis of risk factors and short-term prognostic factors of arrhythmia in patients infected with mild/moderate SARS-CoV-2 Omicron variant
Authors: Yan Lijie , Wu Jintao , Fan Xianwei , Liu Jingjing , Zhang Leiming , Hu Juan , Li Xuejie , Su Yandong , Zhang Futao , Xu Xizheng , Chen Xiaosheng , Yang Haitao
Published: July 2023

Background

Complications, including arrhythmia, following severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection continue to be of concern. Omicron is the mainstream SARS-CoV-2 mutant circulating in mainland China. At present, there are few epidemiological studies concerning the relationship between arrhythmia and Omicron variant infection in mainland China.

Objectives

To investigate the risk factors of arrhythmia in patients infected with the SARS-CoV-2 Omicron variant and the factors influencing prognosis.

Methods

Data from 192 Omicron infected patients with symptoms of arrhythmia (AH group) and 100 Omicron infected patients without arrhythmia (Control group) were collected. Patients in the AH group were divided into the good and poor prognosis groups, according to the follow-up results 4–6 weeks after infection. The general and clinical data between the AH and Control groups, and between the good and poor prognosis groups were compared. The variables with differences between the groups were included in the multivariate logistic regression analysis, and the quantitative variables were analyzed by receiver operating characteristic curve to obtain their cut-off values.

Results

Compared with the control group, the body mass index (BMI), proportion of patients with a history of arrhythmia, proportion of antibiotics taken, heart rate, moderate disease severity, white blood cell (WBC) count, and the aspartate aminotransferase, creatine kinase (CK), CK isoenzyme (CK-MB), myoglobin (Mb), high-sensitive troponin I (hs-cTnI), lymphocyte ratio and high sensitivity C-reactive protein (hs-CRP) levels in the AH group were significantly higher (p < 0.05). In addition, obesity (BMI ≥24 kg/m2), fast heart rate (≥100 times/min), moderate disease severity, and WBC, CK-MB and hs-cTnI levels were independent risk factors of arrhythmia for patients with Omicron infection (p < 0.05), and hs-CRP was a protective factor (p < 0.05). Compared with the good prognosis group, the age, proportion of patients with a history of arrhythmia, heart rate, proportion of moderate disease severity, and hs-CRP, CK, Mb and hs-cTnI levels were significantly higher in the poor prognosis group, while the proportion of vaccination was lower in the poor prognosis group (p < 0.05). Advanced age (≥65 years old), proportion of history of arrhythmia, moderate disease severity, vaccination, and hs-CRP, Mb and cTnI levels were independent factors for poor prognosis of patients with arrhythmia (p < 0.05).

Conclusion

The factors that affect arrhythmia and the prognosis of patients infected with Omicron include obesity, high heart rate, severity of the disease, age. history of arrhythmia, WBC, hs-CRP, and myocardial injury indexes, which could be used to evaluate and prevent arrhythmia complications in patients in the future.
Advances in multi-modal non-invasive imaging techniques in the diagnosis and treatment of polypoidal choroidal vasculopathy
Authors: Wang Yuelin , Gu Xingwang , Chen Youxin
Published: July 2023

Polypoidal choroidal vasculopathy (PCV) is a disease characterized by subretinal pigment epithelium (RPE) orange-red polypoidal lesions and abnormal branching neovascular networks (BNNs). In recent years, various non-invasive imaging technologies have rapidly developed, especially the emergence of optical coherence tomography angiography (OCTA), multi-spectral imaging, and other technologies, which enable the observation of more features of PCV. In addition, these technologies are faster and less invasive compared to indocyanine green angiography (ICGA). Multi-modal imaging, which combined multiple imaging techniques, provides important references for the diagnosis and treatment of PCV with the assistance of regression models, deep learning, and other algorithms. In this study, we reviewed the non-invasive imaging techniques, multi-modal imaging diagnosis, and multi-scene therapeutic applications of PCV, with the aim of providing a reference for non-invasive multi-modal diagnosis and treatment of PCV.
Uncorrelated bilateral cortical input becomes timed across hippocampal subfields for long waves whereas gamma waves are largely ipsilateral
Authors: Hernández-Recio Sara , Muñoz-Arnaiz Ricardo , López-Madrona Víctor , Makarova Julia , Herreras Oscar
Published: July 2023

The role of interhemispheric connections along successive segments of cortico-hippocampal circuits is poorly understood. We aimed to obtain a global picture of spontaneous transfer of activity during non-theta states across several nodes of the bilateral circuit in anesthetized rats. Spatial discrimination techniques applied to bilateral laminar field potentials (FP) across the CA1/Dentate Gyrus provided simultaneous left and right readouts in five FP generators that reflect activity in specific hippocampal afferents and associative pathways. We used a battery of correlation and coherence analyses to extract complementary aspects at different time scales and frequency bands. FP generators exhibited varying bilateral correlation that was high in CA1 and low in the Dentate Gyrus. The submillisecond delays indicate coordination but not support for synaptic dependence of one side on another. The time and frequency characteristics of bilateral coupling were specific to each generator. The Schaffer generator was strongly bilaterally coherent for both sharp waves and gamma waves, although the latter maintained poor amplitude co-variation. The lacunosum-moleculare generator was composed of up to three spatially overlapping activities, and globally maintained high bilateral coherence for long but not short (gamma) waves. These two CA1 generators showed no ipsilateral relationship in any frequency band. In the Dentate Gyrus, strong bilateral coherence was observed only for input from the medial entorhinal areas, while those from the lateral entorhinal areas were largely asymmetric, for both alpha and gamma waves. Granger causality testing showed strong bidirectional relationships between all homonymous bilateral generators except the lateral entorhinal input and a local generator in the Dentate Gyrus. It also revealed few significant relationships between ipsilateral generators, most notably the anticipation of lateral entorhinal cortex toward all others. Thus, with the notable exception of the lateral entorhinal areas, there is a marked interhemispheric coherence primarily for slow envelopes of activity, but not for pulse-like gamma waves, except in the Schafer segment. The results are consistent with essentially different streams of activity entering from and returning to the cortex on each side, with slow waves reflecting times of increased activity exchange between hemispheres and fast waves generally reflecting ipsilateral processing.
Case report: A disconjugate pattern in video head impulse testing hints toward a central cause of acute vertigo
Authors: Wettstein Vincent G. , Feil Bertram , Mono Marie-Luise
Published: July 2023

When acute vertigo occurs, the challenge for the medical practitioner lies in the focused assessment to find the cause of its symptoms. Especially in the case of central pathology, a fast diagnosis is essential for therapy. The head impulse, nystagmus, test of skew (HINTS) protocol and the additional video head impulse test (VHIT) can distinguish between central and peripheral vestibular causes in the acute setting and thus help to set the right path for further evaluation and treatment. In this case, a patient with acute onset of vertigo presented with an unusual pattern in the VHIT. Binocular eye tracking showed a disconjugate horizontal vestibulo-ocular reflex (VOR) with severe loss or gain for the adducting eye yet with a lack of corrective saccades. The abducting eye produced a pattern of mild VOR gain loss yet with pronounced corrective saccades. Together with clinical findings that were compatible with internuclear ophthalmoplegia, a probable central lesion in the medial longitudinal fasciculus (MLF) region was suspected. The patient was sent to a tertiary hospital, where the initial MRI was negative, but due to additional neurological symptoms occurring later, multiple lesions in the cervical spine and cerebellum were detected. The hypothesis of an inflammatory demyelinating disease of the central nervous system (CNS) was made. A further workup led to the final diagnosis of neurosarcoidosis. In a retrospective neuroradiologic assessment, an alteration compatible with a non-active demyelinating lesion in the MLF was detected on secondary imaging as a probable cause of the initial pathophysiologic finding. In this report, we aimed to highlight the unusual case of a disconjugate VOR as a distinctive VHIT pattern hinting toward a central cause of acute vertigo that clinicians should be aware of.
Predictive factors for successful vagus nerve stimulation in patients with refractory epilepsy: real-life insights from a multicenter study
Authors: Pires do Prado Henrique Jannuzzelli , Pinto Lécio Figueira , Bezerra Daniela Fontes , de Paola Luciano , Arruda Francisco , de Oliveira Andrea Julião , Romão Tayla Taynan , Lessa Vanessa Cristina Colares , Silva Jonadab dos Santos , D’Andrea-Meira Isabella
Published: July 2023

Introduction

Vagus nerve stimulation (VNS) therapy is an established treatment for patients with drug-resistant epilepsy that reduces seizure frequency by at least 50% in approximately half of patients; however, the characteristics of the patients with the best response have not yet been identified. Thus, it is important to identify the profile of patients who would have the best response to guide early indications and better patient selection.

Methods

This retrospective study evaluated vagus nerve stimulation (VNS) as an adjuvant therapy for patients with drug-resistant epilepsy from six epilepsy centers in Brazil. Data from 192 patients aged 2–66 years were analyzed, and all patients received at least 6 months of therapy to be included.

Results

Included patients were aged 2–66 years (25.6 ± 14.3), 105 (54.7%) males and 87 (45.8%) females. Median follow-up interval was 5 years (range, 2005—2018). Overall, the response rate (≥50% seizure reduction) after VNS implantation was 65.6% (126/192 patients). Most patients had 50–90% seizure reduction (60.9%) and nine patients became seizure-free. There were no serious complications associated with VNS implantation. The rate of a ≥ 50% seizure reduction response was significantly higher in patients with no history of neurosurgery. The presence of focal without generalized seizures and focal discharges on interictal EEG was associated with better response. Overall, etiological predictors of a better VNS response profile were tumors while a worse response to VNS was related to the presence of vascular malformations and Lennox–Gastaut Syndrome.

Discussion

We observed an association between a better response to VNS therapy no history of neurosurgery, focal interictal epileptiform activity, and focal seizure pattern. Additionally, it is important to highlight that age was not a determinant factor of the response, as children and adults had similar response rates. Thus, VNS therapy should be considered in both adults and children with DRE.