bluuebunny/crossref_metadata_2025 huggingface dataset:
Xilotecnia de la madera de Schinus molle L. de una plantación forestal comercial en Hidalgo, México
Authors: Olvera-Licona Guadalupe , Machuca Roberto , Borja Amparo , Corona Alejandro , Zaragoza Idalia , Arreola Jesús Guadalupe , Jiménez Javier
Published: July 2021

El presente trabajo tuvo como objetivo determinar las características anatómicas, las propiedades físicas, así como estimar las propiedades mecánicas, de la madera de cuatro árboles de Schinus molle L. (pirú) provenientes de una plantación forestal comercial en Tolcayuca, Hidalgo, México. El estudio se realizó en el Laboratorio de Anatomía y Tecnología de la Madera de la División de Ciencias Forestales de la Universidad Autónoma Chapingo. Como resultado se obtuvo que el color de la madera en la albura es rosado, en el duramen es de color café. La madera no tiene olor y sabor característicos, es de brillo medio, veteado pronunciado, hilo inclinado y textura media. La porosidad es semidifusa y el parénquima axial difuso y escaso. Los radios son uniseriados, biseriados y triseriados. Los vasos son cortos, muy abundantes, las fibras son medianas y finas.  Se obtuvo una densidad básica de 0.54 y poder calorífico de 17.246 MJ kg-1 La dureza lateral y en extremos (longitudinal) en condición verde se clasificó como media y baja respectivamente, a 12% de contenido de humedad, se clasificó como media y alta respectivamente; la madera de pirú se clasificó como muy buena para pulpa y papel. La contracción volumétrica total se clasificó como media, la contracción tangencial total: muy alta y la contracción radial total: alta. La relación de anisotropía se clasificó como alta. El punto de saturación de la fibra se describió normal. Por sus características y propiedades de la madera se puede utilizar en la fabricación de muebles, mangos de herramientas y pisos.
Dynamics of the prevalence of modifiable cardiovascular risk factors in the European part of the Russian Federation
Authors: Badin Yu. V. , Polyakov D. S. , Fomin I. V.
Published: July 2021

Objective: to estimate the prevalence in the dynamic of physical inactivity, overweight and obesity, smoking and alcohol abuse in a representative sample of the European part of the Russian Federation. Materials and methods: the population of eight subjects of the European part of Russia was randomized in 2002. The resulting sample was examined by local doctors. The resulting sample included 19,503 respondents who were examined by local doctors in 2002 and 2017. Results: from 2002 to 2017 the prevalence of smoking has decreased from 23,1 to 20,5% (р < 0,001) (47,9 – 42,6% (р < 0,001) among men and 4,8 – 4,5% (р = 0,323 among women)). The smoking index among men has decreased from 18,8 to 17,8 (р = 0,024) and from women increased from 7,7 to 10,6, р < 0,001. The prevalence of alcohol abuse has decreased from 32,2 to 22,3% (р < 0,001) (51,6 – 39,0% (р < 0,001) among men and 17,4 – 10,1% (р < 0,001) among women). Average dose of ethanol, among drinkers has changed from 84,0 ± 94,4 ml to 75,4 ± 75,5 ml (р < 0,001) (120,6 ± 111,9 – 97,7 ± 85,2 (р < 0,001) among men and 44,7 ± 45,3 – 46,0 ± 46,3 (р < 0,001) among women). Percentage of respondents who are overweight or obese has increased from 46,9 to 60,0% (р < 0,001) (41,6 – 58,2% (р < 0,001) among men and 50,9 – 31,3% (р < 0,001) among women). Although the prevalence of inactivity has decreased from 83,2 to 81,0% (р < 0,001) (79,8 – 78,4% р = 0,045 among men and 85,7 – 83,0% (р < 0,001) among women), the proportion of people without physical activity has increased from 71,5 to 74,0% (р < 0,001), because the proportion of people with low physical activity has decreased. Conclusion: the prevalence of bad habits in Russia is decreasing, but the proportion of people who have inactivity, overweight and obesity is increasing. These facts will not significantly reduce cardiovascular morbidity and mortality in Russsia, and require optimization of population prevention programs that will reduce the prevalence of inactivity, overweight and obesity in society.
Analysis of survival and risk factors in recipients with coronary artery disease of a heart transplant
Authors: Stavenchuk T. V. , Kosmachova E. D. , Shelestova I. A. , Barbuhatty K. O. , Kolodina M. V. , Porhanov V. A.
Published: July 2021

Objective: to conduct a comparative analysis of survival rate and development of heart transplant coronary artery disease risk factors during early and late post-transplantation periods. Materials and methods: a retrospective analysis of 58 patients with was conducted in S.V. Ochapovsky Region Clinical Hospital № 1, Krasnodar. Inclusion criteria were patients with vasculopathy; group № 1 — recipients with heart transplant coronary artery disease up until 3 years after heart transplantation; group № 1 — recipients with heart transplant coronary artery desease 3 years after heart transplantation. Endomyocardial biopsy, coronary angiography and immunological examination were used for monitoring heart recipients. Results: survival rate in group № 1 — 51,9%; in group № 2 — 64,5%. During studying the influence of age category on survival rate it was discovered that belonging to the age category influences on the survival rate in group № 1, p – 0,023. Death risk in group №1 is 1,7 (0,59 – 4,85) times higher in comparison with group № 2. When combined heart transplant coronary artery desease with cellular and humoral rejection in group №1 death risk is reliably 2,75 (1,58 – 4,78) times higher (p = 0,010). The frequency of heart transplant coronary artery desease recurrence does not have a meaningful impact on the survival rate of the recipients with heart transplant coronary artery desease n both groups. One of the meaningful risk factors in two groups, which affects heart transplant coronary artery desease development is cytomegalovirus infection. Cellular rejection is also a fact which influences lethal outcome.
Carotid total plaque area as a marker of asymptomatic lower extremity arterial disease
Authors: Genkel V. V. , Shaposhnik I. I. , Lebedev E. V. , Salashenko A. O.
Published: July 2021

Objective: to examine the prognostic value of ultrasound markers of carotid atherosclerosis in relation to the presence of asymptomatic lower extremity peripheral artery disease (PAD). Materials and Methods: the study included 193 patients with carotid atherosclerosis. All patients underwent duplex ultrasound scanning (DUS) of carotid and lower limb arteries. The carotid plaque score (cPS) was determined as the total height of all plaques in the carotid arteries. The carotid total plaque area (cTPA) was estimated in the longitudinal position, the area of plaque was measured in the manual trace mode.Results: asymptomatic lower extremity PAD was diagnosed in 31.6% of patients. The increase in cTPA, in contrast to cPS and the degree of carotid stenosis, was independent predictor of lower extremity PAD and was associated with an increase in the relative risk of its presence by 6.78 times (95% CI 2.48-18.5; p <0.0001). cTPA ≥42.5 mm2 made it possible to diagnose asymptomatic lower extremity PAD with a sensitivity of 70.2% and specificity of 73.0%. Conclusion: In patients with carotid atherosclerosis among carotid atherosclerosis markers only cTPA, in contrast to cPS and the degree of carotid stenosis, had an independent predictive value regarding the presence of asymptomatic lower extremity PAD.
Determining the Evolution of Headache Among Regular Users of a Daily Electronic Diary via a Smartphone App: Observational Study
Authors: Raffaelli Bianca , Mecklenburg Jasper , Overeem Lucas Hendrik , Scholler Simon , Dahlem Markus A , Kurth Tobias , Oliveira Gonçalves Ana Sofia , Reuter Uwe , Neeb Lars
Published: July 2021

Background

Smartphone-based apps represent a major development in health care management. Specifically in headache care, the use of electronic headache diaries via apps has become increasingly popular. In contrast to the soaring volume of available data, scientific use of these data resources is sparse.

Objective

In this analysis, we aimed to assess changes in headache and migraine frequency, headache and migraine intensity, and use of acute medication among people who showed daily use of the headache diary as implemented in the freely available basic version of the German commercial app, M-sense.

Methods

The basic version of M-sense comprises an electronic headache diary, documentation of lifestyle factors with a possible impact on headaches, and evaluation of headache patterns. This analysis included all M-sense users who had entered data into the app on a daily basis for at least 7 months.

Results

We analyzed data from 1545 users. Mean MHD decreased from 9.42 (SD 5.81) at baseline to 6.39 (SD 5.09) after 6 months (P<.001; 95% CI 2.80-3.25). MMD, AMD, and migraine intensity were also significantly reduced. Similar results were found in 985 users with episodic migraine and in 126 users with chronic migraine.

Conclusions

Among regular users of an electronic headache diary, headache and migraine frequency, in addition to other headache characteristics, improved over time. The use of an electronic headache diary may support standard headache care.
Social Networking Site Use During the COVID-19 Pandemic and Its Associations With Social and Emotional Well-being in College Students: Survey Study
Authors: Tuck Alison B , Thompson Renee J
Published: July 2021

Background

Social distancing during the COVID-19 pandemic has reduced the frequency of in-person social interactions. College students were highly impacted, since many universities transferred curriculum from in-person to entirely online formats, physically separating students with little notice. With social distancing, their use of social networking sites (SNSs) likely changed during the COVID-19 pandemic, possibly holding implications for well-being.

Objective

This study aimed to determine (1) how components of SNS use (ie, weekly frequency, time per day, habitual use, engagement, enjoyment, addiction, and emotional impact) changed from before to during COVID-19, (2) how these changes in SNS use were associated with pandemic-related social and emotional well-being, and (3) how SNS use and changes in use during the pandemic were associated with loneliness.

Methods

College students (N=176) were surveyed during the time when their university campus in the United States was operating online. Participants completed the same SNS use questionnaires twice, once with regard to the month preceding the onset of COVID-19 and again with regard to the month since this time. They also reported the extent to which they experienced perceived change in social support resulting from the pandemic, pandemic-related stress, and general loneliness.

Results

After the onset of COVID-19, participants showed an increase in daily time spent on SNSs (t169=5.53, d=0.42, P<.001), habitual use (t173=3.60, d=0.27, P<.001), and addiction (t173=4.96, d=0.38, P<.001); further, enjoyment on SNSs decreased (t173=–2.10, d=–0.16, P=.04) and the emotional impact of SNS activities became more negative (t172=–3.76, d=–0.29, P<.001). Increased perceived social support during COVID-19 was associated with changes in frequency of SNS use, time per day, addiction, and engagement (r>0.18 for all). Pandemic-related stress was associated with changes in SNS addiction and the extent to which one’s SNS content was related to the pandemic (r>0.20 for all). Loneliness was positively associated with SNS addiction (r=0.26) and negatively associated with SNS engagement (r=–0.19) during the pandemic. Loneliness was also negatively associated with changes in habit and engagement (r<–0.15 for all).

Conclusions

Findings suggest that components of SNS use are associated with both positive and negative pandemic-related social outcomes, but largely negative pandemic-related emotional outcomes. Further, some components of SNS use are positively associated with loneliness (eg, addiction) while others show a negative association (eg, engagement). These findings provide a more nuanced picture of how SNS use is associated with social and emotional well-being during the time of a global health crisis when in-person interactions are scarce.
Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods Study
Authors: Veldhuijzen Evalien , Walraven Iris , Belderbos José
Published: July 2021

Background

The Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) item library covers a wide range of symptoms relevant to oncology care. There is a need to select a subset of items relevant to specific patient populations to enable the implementation of PRO-CTCAE–based symptom monitoring in clinical practice.

Objective

The aim of this study is to develop a PRO-CTCAE–based subset relevant to patients with lung cancer that can be used for monitoring during multidisciplinary clinical practice.

Methods

The PRO-CTCAE–based subset for patients with lung cancer was generated using a mixed methods approach based on the European Organization for Research and Treatment of Cancer guidelines for developing questionnaires, comprising a literature review and semistructured interviews with both patients with lung cancer and health care practitioners (HCPs). Both patients and HCPs were queried on the relevance and impact of all PRO-CTCAE items. The results were summarized, and after a final round of expert review, a selection of clinically relevant items for patients with lung cancer was made.

Results

A heterogeneous group of patients with lung cancer (n=25) from different treatment modalities and HCPs (n=22) participated in the study. A final list of eight relevant PRO-CTCAE items was created: decreased appetite, cough, shortness of breath, fatigue, constipation, nausea, sadness, and pain (general).

Conclusions

On the basis of the literature and both professional and patient input, a subset of PRO-CTCAE items has been identified for use in patients with lung cancer in clinical practice. Future work is needed to confirm the validity and effectiveness of this PRO-CTCAE–based lung cancer subset internationally and in real-world clinical practice settings.
Performance Evaluation and Multicenter Consistency Study of Smartphone-based Hipee S2 Point-of-care Testing Urine Dipstick Analyser: Evaluation Study (Preprint)
Authors: Zhang Qiang , Wang Guoqing , Zong Xiaolong , Sun Jinghua
Published: July 2021

BACKGROUND

With advances in mobile technology, smartphone-based point-of-care testing (POCT) urinalysis hold great potential for disease screening and health management for clinicians and individual users. The POCT devices need to have good analytical and clinical performance, but data are lacking.

OBJECTIVE

The purpose of this study is to evaluate the analytical performance of smartphone-based Hipee S2 POCT urine dipstick analyser.

METHODS

A total of 1,603 urine samples from three hospitals were collected. Precision, drift, carry-over, interference, and method comparison of Hipee S2 were evaluated.

RESULTS

The precision for each parameter, assessed by control materials, was acceptable. No sample carry-over or drift was observed. Ascorbate solution with 1 g/L had an inhibitory effect for the haemoglobin test. Agreement for specific gravity (SG) varied between moderate to substantial, for pondus hydrogenii (pH) was moderate, and for other parameters varied between substantial to excellent, on comparing the results obtained by Hipee S2 with those measured by laboratory reference analysers. The semi-quantitative results of microalbumin and creatinine were highly correlated with the quantitative results.

CONCLUSIONS

Hipee S2 POCT urine analyser showed acceptable analytical performance as a semi-quantitative method. It serves as a convenient alternate device for clinicians and individual users for urinalysis and health management.
From the Cochrane Library: Topical Tacrolimus for Atopic Dermatitis (Preprint)
Authors: Hamp Austin , Anderson Jarett D , Sivesind Torunn E , Szeto Mindy D , Cury-Martins Jade
Published: July 2021

UNSTRUCTURED

N/A
Using UK Biobank for sexual minority health research
Authors: Saunders Catherine L , Massou Efthalia
Published: July 2021

Aim:
Despite poorer health and healthcare outcomes experienced by lesbian, gay and bisexual adults, data for research to characterize and address these disparities remain limited.
Patients & methods:
We describe sexual history information from 502,543 UK Biobank participants recruited between 2006 and 2010, as sexual identity was not collected from the cohort at baseline, and compare this with sexual history and sexual identity responses to the third National Survey of Sexual Attitudes and Lifestyles (NATSAL-3), collected between 2010 and 2012.
Results:
After exclusions, 700 (0.3%) women and 2112 (1.2%) men in UK Biobank reported a history of exclusively same-sex sex and 5162 (2.3%) women and 4275 (2.3%) men reported a history of sex with both women and men; estimates were consistent with, although slightly lower those from NATSAL-3.
Conclusion:
UK Biobank is an important resource for sexual minority health research.
Educación integral en la infancia: un aula innovadora, exitosa y feliz
Authors: Cobaleda Estepa Mónica Pilar
Published: July 2021

La educación integral en la infancia es fundamental para desarrollar las capacidades cognitivas, comunicativas, afectivas, sociales, creativas y práxicas de los estudiantes. Por ello, la dinamización de las estrategias de enseñanza-aprendizaje con enfoque holístico adquieren relevancia en todo momento. Este trabajo presenta la estrategia aief —aula innovadora, exitosa y feliz— para la educación integral en la infancia con un enfoque en la innovación, lo lúdico, el arte, el desarrollo del pensamiento científico, la inteligencia emocional y el aprendizaje significativo en el proceso formador, que incluye el uso innovador de las tecnologías y su relación con el contexto cultural. Además, se presentan los principios orientadores y un conjunto de didácticas transversales que pueden ser aplicadas directamente o con las adaptaciones de contexto por parte de otros maestros. Esta estrategia permite así, generar procesos donde, tanto el estudiante como el maestro, se renuevan constantemente y, desde su praxis, se hacen conscientes de las transformaciones de su rol que circula entre el aprender y enseñar.
Flautistas, bagels y tortillas: la vida secreta de ratas y ratones
Authors: Tapia Ramírez Gloria , Hernández Núñez Aarón
Published: July 2021

Ratas y ratones forman parte del imaginario de la humanidad. Muchos son los mitos que giran en torno a su aspecto, hábitos o estadios de desarrollo. Han sido tratados como deidades por algunas culturas y despreciados por muchas otras. No obstante, han acompañado a la humanidad a lo largo de su historia y comparten un lazo común, incluso en aspectos de salud pública. Este texto recopila datos sobre muchos de los mitos acerca de las ratas y ratones y los clarifica con información científica reciente; asimismo, explica su papel en los ecosistemas naturales y en la salud humana.
Estigma hacia el aborto y sus consecuencias: acciones para reducirlo
Authors: Orihuela-Cortés Fabiola , Marván Ma. Luisa
Published: July 2021

El estigma es la devaluación social que vive una persona por poseer características que van en contra de las normas culturales establecidas. El aborto, a pesar de ser un procedimiento muy común, está sumamente estigmatizado debido a que, en el entendimiento colectivo, se tiene como una práctica moralmente equivocada y socialmente inaceptable. En el presente artículo, se abordarán los diferentes niveles de la sociedad en los que se manifiesta este estigma, como lo son: el nivel de los medios de comunicación y opinión pública, el nivel estructural o legal, el nivel institucional, el nivel comunitario, y el nivel individual. De igual manera, es importante conocer las diversas acciones que realiza la sociedad civil para reducir el estigma hacia el aborto, por lo que se enlistan distintas asociaciones que tienen como propósito la reivindicación del aborto mediante grupos de reflexión, cursos, campañas, videos, talleres, entre otras acciones. Por último, se proponen algunas acciones individuales que se pueden realizar con el fin de reducir el estigma entorno al aborto.
Burnout, empatía y grados de exposición al COVID-19 en empleados dominicanos
Authors: De los Santos Mateo Carlina , Vasquez Karla Patricia , Fernández Morales Michelle Dennise , Henríquez Cross Analía
Published: July 2021

Existen estudios que relacionan Burnout y Empatía, sin embargo, no contemplan variables sociodemográficas externas como las incluidas en esta investigación; tampoco se han analizado con respecto a Grados de Exposición al COVID-19. El objetivo principal de este estudio es identificar si existe una relación entre Grados de Exposición al COVID-19, Burnout, Empatía Cognitiva y Empatía Afectiva. En esta investigación participaron 120 personas, elegidas a través de un muestreo no probabilístico de tipo intencional y voluntario. Para medir el Burnout se utilizó el Screening Inventory (BSI: Dávila y Nevado, 2016), mientras que la Empatía fue evaluada a través del Empathy Quotient (EQ: Redondo y Herrero-Fernández, 2018). Grados de Exposición al COVID-19 se midió con una subescala de un instrumento desarrollado por Herbas (2020) que mide factores que inciden en la adopción de comportamientos que reducen el contagio del virus. Los resultados no muestran correlaciones entre el Burnout con los ingresos económicos o ambos tipos de Empatía. No obstante, existen correlaciones positivas y significativas entre Empatía Afectiva y Grados de Exposición al COVID-19 en profesionales de la salud (r = .66, p< .05), entre Empatía Cognitiva y Empatía Afectiva (r = .46, p < .01) y entre ingresos económicos y Grados de Exposición al COVID-19 (r = .20, p <.05). Por último, el estudio señala la necesidad de evaluar el Burnout, durante la pandemia COVID-19, para mitigar sus efectos negativos sobre poblaciones como los profesionales de la salud.
Impacto de las medidas administrativas ante el COVID-19, en las dinámicas socioculturales en Cuetzalan del Progreso, Puebla
Authors: Arias-Hernández Jazmín , Reyes Pérez Oscar
Published: July 2021

La pandemia causada por el COVID-19 ha llevado a tomar diversas medidas que puedan reducir la probabilidad de contagio; sin embargo, e independientemente de su efectividad, se han visto afectados varios sectores sociales y económicos, como el turístico. Esto ha sido particularmente complicado en poblaciones cuya principal actividad económica es el turismo.

Este artículo pretende develar las implicaciones que han tenido las restricciones al turismo en un “pueblo mágico” de México, cuya población es principalmente originaria (masewal) y presenta altos niveles de marginación socioeconómica. A través de una metodología etnográfica basada en entrevistas no estructuradas, observación participante y observación natural, se evaluó la eficiencia e impacto de las decisiones tomadas por el ayuntamiento municipal para evitar los contagios por COVID-19 en Cuetzalan del Progreso.

Los resultados muestran que las medidas no se cumplieron completamente debido a que las decisiones no se tomaron con la participación de los habitantes ni se tuvieron en consideración sus carencias económicas y su alta dependencia del turismo como medio de subsistencia. Por otro lado, las restricciones afectaron principalmente la economía de las personas más pobres, quienes dependen de sus labores diarias para obtener ingresos. A pesar de la situación, el municipio de Cuetzalan del Progreso se caracteriza por su resiliencia territorial, lo que se reflejó en el diseño de estrategias comunitarias para el fortalecimiento social.
Conducta alimentaria y consumo de alcohol durante el distanciamiento social por COVID-19 en México: un estudio exploratorio
Authors: Carrillo Valdez Lindsay , Reyes Muñiz Juan Manuel , Escamilla Gutiérrez María Luisa , González Baena Viviana
Published: July 2021

El distanciamiento social por COVID-19 puede ser una experiencia asociada a emociones desagradables y estrés, capaz de exacerbar la ingesta emocional de comida y bebidas alcohólicas como forma de afrontamiento. Con el objetivo de explorar la conducta alimentaria y el consumo de alcohol durante el distanciamiento social por COVID-19 e identificar las variables psicosociales asociadas a dichas conductas, se diseñó un estudio transversal exploratorio, descriptivo y correlacional, con aplicación de una encuesta en línea, a una muestra no probabilística de 1110 mexicanos. A partir del análisis de regresión lineal múltiple, se encontró que las variables: estrés, conductas negativas, ansiedad, sexo femenino, convivencia con un familiar con diagnóstico de COVID-19 y lugar de residencia en el interior de la República Mexicana son factores que predicen el consumo excesivo de comida durante el distanciamiento físico, mientras que el apoyo social es un factor protector (R2= .286). Por otra parte, el modelo para el consumo de alcohol durante la cuarentena incluyó las variables estrés y ansiedad como predictores, así como sexo femenino, edad, ocupación y distracción como factores protectores (R2= .205). Se concluyó que las variables psicosociales identificadas posibilitan el diseño de estrategias de intervención orientadas a mitigar y/o potenciar el efecto de dichas variables sobre la conducta alimentaria y el consumo de bebidas alcohólicas en situaciones altamente estresantes como la crisis sanitaria actual.
Recommendations to the command staff on maintaining a stable psychological state of the crew of an emergency submarine
Authors: Andrijchenko А. М. , Yemushintsev P. A. , Mikulich V. V.
Published: July 2021

Purpose: systematization of recommendations to the submarine command personnel on personnel management and first psychological aid in an emergency, based on the previously theoretically modeled dynamics of the psychological state of the crew of an emergency submarine.

Materials and methods:analysis of methodological manuals for preserving and improving the working capacity of a person in stressful situations, studying the available literature on the actions of submarine personnel at the time of the accident.

Results and discussion:based on the results of the previously studied factors affecting the dynamics of the psychological state of the crew of the damaged submarine, the selection and systematization of the available methods of influence and management of personnel in different periods of the development of the accident was carried out, possible methods of self-control and self-regulation of the psychoemotional state were proposed to the command personnel.
The acute odontogenic infection in maritime medicine: clinical and radiological parallels
Authors: Serikov A. A. , Iordanishvili A. K.
Published: July 2021

Relevance. The main thing in the prevention of acute odontogenic infection in sailors during long voyages is the full implementation of the pre-voyage sanitation of the oral cavity, which provides for the elimination of chronic foci of odontogenic infection.

The aimof the study was to identify chronic foci of odontogenic infection in sailors after the completion of their prevoyage sanitation of the oral cavity and before going sailing.

Material and methods. Dental and X-ray (orthopantomography) examination of 169 men aged 22 to 52 years after completion of dental treatment (oral cavity sanitation) before a long sea voyage was carried out, followed by analysis of clinical and radiological parallels to identify chronic odontogenic foci of infection, which can be a potential source of microorganisms for the development of acute odontogenic infection during swimming.

Results and discussion.It was found that, despite the ongoing treatment and prophylactic work on the rehabilitation of the oral cavity with the sailors in the pre-voyage period, in 30.4-77.2% of cases they retain chronic foci of odontogenic infection during a long sea voyage, which can become the cause of the development of acute odontogenic infection. For the qualitative detection of chronic odontogenic foci of infection, it is necessary to supplement the dental examination of sailors in the pre-voyage period with an X-ray examination, which will allow timely identification and elimination of chronic odontogenic inflammation of the maxillary sinuses, as well as chronic periapical and periodontal foci of odontogenic infection.
Human biomonitoring as a method for assessing the impact of chemical factors on workers of the ship repair and shipbuilding industry
Authors: Morozov D. Yu.
Published: July 2021

Purpose: to highlight the problem of assessing the impact of chemical factors on the health of personnel of enterprises engaged in ship repair and shipbuilding by conducting research on human biomonitoring.

Materials and methods.The content analysis of various domestic and foreign scientific sources, as well as regulatory documents of different countries related to human biomonitoring in industry was carried out. A comparison is made between different normative values of biological exposure indices in different countries.

Results and discussion. It is established that human biomonitoring as a method of assessing the impact of chemicals on human health is already actively developing both in our country and abroad. The complexity of the evidence base based on the principles of evidence-based toxicology, which allows us to establish standard values for biomarkers in the human body due to a deep understanding of toxic and dynamic processes in the body, does not yet allow us to create a full-fledged regulatory framework and make the nature of human biomonitoring activities mandatory in the workplace. However, work in this direction is currently underway. At the same time, some countries have already developed a number of documents that allow for human biomonitoring at enterprises, despite their exclusively advisory nature.
Мethodological approaches to substantiating the nomenclature of anthropometric indicators of operators in the interests of designing marine engineering workplaces
Authors: Sedov A. V. , Moiseev Yu. B. , Khankevich Yu. R. , Rogovanov D. Yu. , Bloshchinsky I. A. , Sapozhnikov K. V. , Porozhnikov P. A. , Yurchik N. V.
Published: July 2021

The article provides an analysis of regulatory and technical documents and reference data that determine the nomenclature of anthropometric indicators for various professional categories of personnel. It is shown that the anthropological indicators given in these sources have lost their relevance due to the acceleration of the planet’s population over the past decades, as well as the absence of a whole group of necessary characteristics for the design of marine equipment. So in the standards of the 1980s, the average value of a person’s height for the 95th percentile is 183 cm, and in the European standards of 2000, the height of a man for the 95th percentile is 188.1 cm. The role of dynamic anthropometric characteristics in the justification of ergonomic requirements for control systems is shown. The basic static and dynamic anthropometric indicators necessary for the design of promising marine equipment are determined.
Differences in biological efficiency of one- and two-component graminicide on sugar beet crops in Tula region
Authors: Kryukova Kristina Dmitrievna , Gresis Valeriya Olegovna
Published: July 2021

One of the most urgent tasks in sugar beet production for Russia today is irregularities in cultivation technology and a low-efficiency crop protection. It leads to a high level of weed infestation of agricultural fields. Developing and identifying the most efficient, selective and accessible herbicides, which have low phytotoxicity, do not have a negative effect on soil chemical characteristics and can be used in sugar beet cultivation is relevant today. The aim of this study was to examine and compare biological efficiency of various doses and concentrations of one- and two-component graminicides on sugar beet crops against the following weeds: Cockspur grass Echinochloa crusgalli (L.) Beauv., Wild millet Setaria glauca (L.) Beauv. and Couch Grass Elytrigia repens (L.) Nevski. The experiment was conducted on the territory of the Tula region in 2020. The total field experiment area was 480 m2. Application of clethodim + quizalofop-P-ethyl (0.5 l/ha) resulted in reducing the number and weight of annual weeds by 6471 %, reducing the number and weight of perennial weeds by 5458 %, which had the same efficiency as clethodim (0.6 l/ha). The efficiency of clethodim + quizalofop-P-ethyl (1.0 l/ha) was higher than Clethodim (0.6 l/ha) and amounted to 7387 % of reduction in the number of weeds compared to the control, but was lower than Clethodim (1.8 l/ha), which resulted in 8995 % reduction in the number of weeds compared to the control. The highest sugar beet yields were obtained in the variants with clethodim (1.8 l/ha) and two-component herbicide (1 l/ha), which amounted to 28 and 25 % yield increase, in comparison with the control.
Phylogenetic analysis and designing new primers for molecular identification of Drosophila suzukii
Authors: Naserzadeh Yousef , Bondarenko Galina Nikolaevna , Kolesnikova Ekaterina Vladimirovna , Pakina Elena Nikolaevna
Published: July 2021

The family Drosophilidae includes over 3750 species worldwide and over 2000 of these are species of Drosophila. Spotted wing drosophila (SWD), Drosophila suzukii is one of the most dangerous species in this family. The insects live on undamaged ripening fruits, using its peculiar serrated ovipositor to break the skin of fresh ripening fruits and lay eggs in it. Drosophila species are very difficult and practically impossible to detect at larval stages. The present investigation was conducted at the All-Russian Plant Quarantine Center and Agrarian and Technological Institute of RUDN University, Moscow, Russia in 20182020. The aim of this study was to investigate the method of accurate and rapid identification of D. suzukii, and to design specific primer pairs for pest identification by Real-Time PCR method. The real-time quantitative PCR is a fast, sensitive, repeatable and accurate method for quantifying gene transcript levels. In this study, we designed specific primers (4.Dsuz.FRP) for Real-Time PCR to identify D. suzukii from other relative species. Although D. suzukii is absent in the Russian Federation and has not been reported so far, the project could be a precautionary measure.
Using commercial enzyme immunoassay for measuring pregnancy-associated glycoproteins to diagnose pregnancy in dairy cows under field conditions in Algeria
Authors: Ayad Abdelhanine , Derbak Hanane , Besseboua Omar
Published: July 2021

The purpose of the present work was to study effectiveness for early pregnancy diagnosis in cattle of the new enzyme immunoassay (EIA) sandwich kit commercially available based on the measurement of pregnancy-associated glycoproteins (PAGs). 120 Holstein-Friesian cattle of mixed age and parity were comprised from different dairy herds. The pregnant females (n = 68) were diagnosed by ultrasonography at day 35-40 after artificial insemination and confirmed by transrectal exploration at 2-3 months after AI. The non-pregnant females (n = 52) were housed in the absence of males during the experimental period. Blood samples were collected from coccygeal vessels of females into EDTA tubes. The serum was obtained by centrifugation and the serum was stored at - 20 C until assay. The PAG concentrations in pregnant and non-pregnant females were determined in serum by EIA kit. The reproducibility inter- and intra-assay of the PAG-EIA is satisfactory (2.78 and 13.19 %, respectively). The accuracy ( 94.8 %) and the test of parallelism were largely acceptable. No cross-reaction was observed with the different hormones tested at different dilutions. PAG-EIA system gave 100 % sensitivity and negative predictive values. Whereas, specificity and positive predictive value were 91.93 and 71.15 %, respectively. The accuracy of pregnancy diagnosis by PAG-EIA was 87.5 %. In conclusion, the present study shows clearly that the EIA kit can be used to measure PAG in serum cows for the detection of gestation in Algeria. Therefore, this alternative technique could be recommended to replace the radioactive methods in immunoassays to improve the reproductive performances and an efficient tool for reproductive management of dairy cattle.
Influence of grain physical characteristics on functional value of poultry feed
Authors: Polonskiy Vadim Igorevich , Sumina Alena Vladimirovna
Published: July 2021

The purpose of this investigation was to analyze the scientific literature concerning the influence of grain physical characteristics on functional value of poultry feed. The review considers the role of grain feed particle size and its shape in ensuring optimal development and functioning of digestive tract and increasing productivity of birds. The results showed that compared to the feeding with smaller particles, the use of coarse feed increased stomach weight in broilers, enhanced enzymatic degradation of feed in digestive tract and improved nutrient bioavailability. The study found that increase in the level of coarse corn in the diet increased the number of Lactobacillus spp. and Bifidobacteria spp. beneficial bacteria in digestive tract. Meanwhile, number of opportunistic pathogenic microorganisms decreased. In birds which were given granular feed we found insufficient development of stomach, mainly due to the lack of mechanical stimulation. We assume that in order to improve stomach function and health of birds, it is necessary to apply a source of dietary fiber to their diet. The results of studies suggest that adding 2-3% of insoluble source of fiber to the routine diets of young chickens based on high-protein soy flour and corn can improve their digestive tract development and growth characteristics.
MODEL PENGUKURAN KINERJA RANTAI PASOK PADA PERCETAKAN DIGITAL MENGGUNAKAN PENDEKATAN SUPPLY CHAIN OPERATION REFERENCE (STUDI KASUS PADA PT PITU KREATIF BERKAH)
Authors: Muhammad Shalahuddin , Zulkarnain Zulkarnain , Silvia Deli
Published: July 2021

Banyaknya kegiatan manajemen rantai pasok (Supply Chain Management) yang dilakukan oleh PT Pitu kreatif Berkah menyebabkan perusahaan kesulitan dalam memutuskan atribut mana yang harus diprioritaskan ketika melakukan peningkatan. Penelitian ini bertujuan untuk mengukur kinerja rantai pasok perusahaan dengan menggunakan pendekatan Supply Chain Operation References (SCOR). Key Performance Indicator (KPI) disesuaikan dengan kegiatan rantai pasok perusahaan. Tingkat kepentingan KPI diukur berdasarkan hasil kuesioner subjektif dari para ahli. KPI dengan nilai kinerja terbobot terendah adalah waktu rata – rata persiapan dengan kinerja terbobot 0.91%; sementara KPI tertinggi adalah produk jadi sesuai rencana dengan nilai 9.6%. KPI rantai pasok yang masih perlu ditingkatkan adalah barang jadi yang tersimpan, waktu pengiriman barang pesanan, jumlah penambahan pesanan yang dapat dipenuhi supplier, persentase produk reject selama proses produksi, jumlah insheet perpesanan, dan rata – rata waktu persiapan dengan indikator Average. Nilai total kinerja perusahaan sebesar 89.06%. Nilai ini menunjukkan bahwa kinerja rantai pasok perusahaan berada pada posisi Good.
PENERAPAN PERENCANAAN KAPASITAS PRODUKSI DENGAN PERHITUNGAN METODE ROUGH CUT CAPACITY PLANNING (RCCP) DI PERUSAHAAN PANEL LISTRIK
Authors: Septriani Anisa , Alfa Bonitasari Nurul
Published: July 2021

Perusahaan panel listrik ini memproduksi Panel Listrik berdasarkan pesanan (make-to-order). Hal tersebut menimbulkan jadwal pendistribusian yang sudah dijadwalkan sebelumnya tidak mencapai waktu yang tepat, sehingga menjadikan target produksi tidak tercapai. Kapasitas produksi di perusahaan panel listrik ini yang belum mampu memenuhi beban produksi dan menyelesaikannya tepat waktu, dikarenakan kapasitas produksinya yang belum diketahui yang mengakibatkan penumpukan (bottleneck) sehingga kegiatan keterlambatan pruduksi untuk menyelesaikan dengan tepat waktu. Dalam kegiatan produksinya sering terjadi masalah penumpukan (bottleneck) yaitu pada stasiun kerja Pra Mechanical, Coating, dan Assembly.  Tujuan penelitian ini akan melakukan perencanaan kapasitas produksi dari tiap staisun kerja dengan perhitungan Rough Cut Capacity Planning (RCCP) untuk memecahkan masalah perusahaan yang berkaitan dengan kapasitas produksi. Rough Cut Capacity Planning (RCCP) menghitung kebutuhan kapasitas secara kasar dan membandingkannya dengan kapasitas yang tersedia. Terjadi penumpukan pada beberapa stasiun kerja yang diperoleh dari perhitungan kapasitas produksi dengan metode pendekatan RCCP yaitu lini produksi pra assembly mechanical pada bending machine, lini produksi assembly mechanical pada  assembly rangka dan drilling machine, lini produksi coating pada coating treatment, lini produksi electornic mechanical pada punching cu machine, lini produksi electrical pada assembly cu. Dengan menggunakan perhitungan Rough Cut Capacity Planning (RCCP) dapat diketahui kapasitas yang dibutuhkan untuk penambahan mesin-mesin produksi atau penambahan jumlah pekerja serta penambahan jam kerja (lembur).
Cherubina de Gabriak: French Sources of the Mystification
Authors: Savina Anfisa D.
Published: July 2021

The article shows what role M. Voloshin’s interest in the work of Auguste Villiers de l’Isle-Adam played in the creation of Cherubina de Gabriak. This famous mystification was planned by M. Voloshin and E. Dmitrieva in the summer of 1909 when the poet was translating Villiers’ philosophical drama Axel and writing an essay about the play and its author. Shared motifs and images that were discovered in Cherubina’s poems, Villiers’ drama and Voloshin’s essays, allow to treat the heroine of Axel (Sara de Maupers) as a literary prototype of the fictional poetess and to assert that Cherubina- Dmitrieva’s poetry was influenced by Villiers’ works and Voloshin’s interpretation of the former’s life. Also, it is important that Voloshin’s attention on Villiers’ novel Future Eve could serve as an impulse to creation of the ideal illusory poetess: an article about this work figured in Voloshin’s first projects for Apollon magazine, S. Makovsky wrote about the heroine of this novel in his memoirs of Cherubina.
Food Symbolism in the World of Vision of Piers Plowman
Authors: Sergeeva Valentina S.
Published: July 2021

W. Langland’s allegorical poem Vision of Piers Plowman is one of the key works of the medieval religious literature. Scenes of eating or drinking are among its most important episodes. The sacral meaning of food in the poem originates in the context of medieval theology appearing around certain evangelic images (“I am the bread of life,” etc.) Each time when the characters eat or drink the realization of Christian dogmas is having place, or, on the contrary, they are refused, because the abundance of “daily bread” leads to spiritual deafness. Gluttony goes hand in hand with hypocrisy, and in the world of the poem it appears not only as over-eating but also as rejecting any real Christian practice. A glutton wastes goods he could give out to the needy, as well as the treasures of his soul; and if he is of the learned, he deprives the “little ones” of their spiritual repast, too. W. Langland includes everyday events and doings into the supertemporal Bible narrative, thus actualizing them for all his Christian readers. As the result of such text organization, food-related episodes appear to be linking spots for the main themes of the poem (Christian life, charity, love, knowledge).
The Trickster Hero in M. Frisch’s Novel My Name Be Gantenbein
Authors: Kuzin Ivan V.
Published: July 2021

The article offers an interpretation and analysis of the novel My Name Be Gantenbein, allowing to find an explanation to the genre uncertainty of the work of the Swiss writer M. Frisch. Due to the non-linear stylistics of the narrative, the image of Gantenbein eludes an unambiguous classification in terms of moral and ethical problematics lying on the surface. The hero of the novel turns into a methodological principle that clarifies the fundamental existences of life. In classical tradition, these included the concepts of freedom and law, truth and lies, truth and deception, game and life. The complicated plot makes Gantenbein a functional representative of both freedom and blind law. They create semantic space of self-organizing life. As a result, the character is endowed with properties of a trickster, because he accepts the complexity of such a life at the level of his existence. The investigation reveals that the game, roles and masks create the ideological basis of the story. This framework directs the reader to perceive life in its everyday manifestations, contributing to the development of an antidote to escapism.
Pharmacokinetically-guided dosing to improve the efficacy of brigatinib in non-small cell lung cancer patients
Authors: Koele Simon , Beek Stijn van , Wekken Anthonie van der , Piet Berber , Heuvel Michel van den , Heine Rob ter
Published: July 2021

Brigatinib was recently approved for the treatment of anaplastic
lymphoma kinase-positive non-small cell lung cancer and is dosed
according to a one-dose-fits-all paradigm. We aimed to identify a
pharmacokinetically-guided precision dosing strategy to improve
treatment response with brigatinib through simulations using a
previously published pharmacokinetic-pharmacodynamic model. Dosing
strategies explored were the approved 180mg QD, the highest tolerable
dose tested in clinical trials: 240mg QD, and two precision dosing
strategies targeting the median trough concentrations following 180mg
QD, and 240mg QD. We investigated the impact of alternative dosing
regimens on progression-free survival (PFS), overall survival (OS), and
the probability of developing a grade ≥2 rash or grade ≥2 amylase
increase. Median PFS and OS increased by 1.6 and 7.8 months,
respectively between the currently approved dosing strategy and
precision dosing to the median trough concentration of the 240mg dosing
strategy, with only a minor increase in the probability of developing
toxicity.
Hybrid, Endovascular, or Open Approach -- the Paget Schroetter Syndrome Dilemma
Authors: Bashir Mohamad , Tan Cian , Salahia M Ghali , Whiston Richard , White Richard , Bailey Damian , Williams Iam
Published: July 2021

Background Paget-Schroetter Syndrome (PSS) is an uncommon disorder
involving thrombosis of the subclavian vein, often caused by repetitive
overuse or compression by the surrounding anatomical structures. Optimal
management of PSS is a subject of debate, but current trends suggest
that a hybrid approach employing endovascular intervention and open
decompression may yield the best clinical results. This original article
examines the roles played by endovascular thrombolysis, surgical
decompression, and postoperative secondary intervention in the
management of PSS. Methods Current literature on the management of PSS
was reviewed and evaluated to ascertain what strategy of intervention
would be optimal. In addition, clinical data from the University
Hospital of Wales on the clinical outcomes in PSS patients undergoing
different surgical approaches for anatomical decompression are included.
Results Evaluation of data from the included series and available
literature seems to indicate that endovascular thrombolytic devices such
as the AngioJet or mechanical thrombectomy offer superior results than
traditional catheter-directed thrombolysis. In addition, adjunctive
procedures such as superior vena cava filters and venous angioplasty or
bypass may augment maintenance of the subclavian vein lumen.
Nonetheless, the subclavian vein must still be relieved of pressure from
surrounding structures for treatment to be successful. Conclusions A
hybrid approach to the management of PSS, encompassing endovascular and
surgical interventions could possibly offer optimal clinical outcomes as
both intrinsic lesions and extrinsic compression of the subclavian vein
are resolved. This article recommends prospective research to determine
the ideal endovascular treatment, and best surgical approach for
decompression.