bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal retrofit design of extractive distillation to energy efficient thermally coupled distillation scheme
Authors: Van Duc Long Nguyen , Lee Moonyong
Published: August 2012

Design and optimization procedures employing the response surface methodology (RSM) for retrofitting the conventional extractive distillation sequence to a thermally coupled extractive distillation scheme (TCEDS—SR) is presented. The optimum TCEDS—SR structure can be found in a practical manner with minimal simulation runs. Furthermore, the RSM allows the interactions between variables to be identified and quantified. The separation of close boiling point mixtures and azeotropic mixtures was examined to test the proposed method. The predictions agreed well with the results of a rigorous simulation. The results showed that a retrofit of the extractive distillation sequence to TCED—SR can achieve significant energy savings compared to the conventional extractive distillation sequence. © 2012 American Institute of Chemical Engineers AIChE J, 59: 1175–1182, 2013
Assessing pre‐implantation embryo development in mice provides a rationale for understanding potential adverse effects of ART and PGD procedures
Authors: Martínez‐Frías María Luisa
Published: August 2012

Although the molecular events controlling human pre‐implantation development remain unclear, mechanisms have been identified by analyzing these stages in mice. Through this approach, considerable insight has been gained into the events that operate to determine the first two cell fate decisions, occurring from zygote formation to the blastocyst prior to implantation. These mechanisms are related to cell polarization, cell division, cell–cell contact, and cell spatial position. Two developmental stages are essential for these processes to proceed adequately. Firstly, the second polar body must anchor to the external membrane during the first mitotic divisions of the embryo as its position is strongly biased to determine the plane of polarity. This in turn has important influence on the fate of the early blastomeres. Secondly, in the transition from the 8‐ to 16‐cell stage, the cells that will form the inner cell mass are determined. Moreover, analyses performed on human oocytes and embryos have identified similar processes to those reported in mice and thus are evolutionarily conserved. Therefore, the understanding of mice pre‐implantation embryo development provides a rationale to interpret current results of potential long‐term adverse outcomes of Assisted Reproductive Technologies and Pre‐implantation Genetic Diagnosis (PGD). © 2012 Wiley Periodicals, Inc.
Synthesis of platinum acetylide complexes and their application in curing silicone rubber by hydrosilylation
Authors: Li Jiayun , Peng Jiajian , Deng Yuan , Ma Chao , Zhang Guodong , Bai Ying , Lai Guoqiao
Published: August 2012

Eight platinum acetylide complexes have been synthesized and characterized. The catalytic properties of these complexes in curing silicone rubber by hydrosilylation have been tested. Among the complexes tested,trans‐Pt(PPh3)2[―C≡CC(CH3)2OSi(CH3)3]2(2),trans‐Pt(PPh3)2[―C≡CC(CH3)2OSi(CH2CH3)3]2(3),trans‐Pt(PPh3)2[―C≡CC(CH3)2OSiPh(CH3)2]2(4),trans‐Pt(PPh3)2[―C≡C(C6H10)OSi(CH3)3]2(6),trans‐Pt(PPh3)2[―C≡C(C6H10)OSi(CH2CH3)3]2(7), andtrans‐Pt(PPh3)2[―C≡C(C6H10)OSiPh(CH3)2]2(8) exhibited sufficiently long pot‐lives (15 days) at room temperature and short silicone rubber curing times of 10–35 min at 100°C or 1–5 min at 120°C. Copyright © 2012 John Wiley & Sons, Ltd.
Synthesis, structural characterization and antimicrobial activity of mixed aryl–alkyl diorganotin(IV) compounds with quinoline‐2‐carboxylate (L−): {RR′SnLCl}n and RR′SnL2
Authors: Vafaee Marzieh , Amini Mostafa M. , Khavasi Hamid Reza , Ng Seik Weng , Tiekink Edward R. T.
Published: August 2012

A series of unsymmetrical diorganotin derivatives of quinoline‐2‐carboxylic acid (LH), namely polymeric {MePhSnClL}n (1) and {EtPhSnClL}n (2), and mononuclear MePhSnL2 (3) and EtPhSnL2 (4), was synthesized by the reaction of LH with the MePhSnCl2, EtPhSnCl2, MePhSnO, and EtPhSnO precursors, respectively. The compounds were characterized by elemental analysis and infrared spectroscopy, as well as by 1 H, 13 C and 119Sn NMR. The molecular structures of representative compounds 2 and 4 were determined by single‐crystal X‐ray crystallography. This study showed that polymeric 2 adopts a distorted octahedral geometry as the carboxylate ligand N,O chelates an Sn atom and at the same time bridges a neighbouring Sn atom via the second O atom, with the remaining sites being occupied by the Cl and two C atoms; the O atoms are trans to each other. The result of the μ2‐bridging mode of L− is the formation of a supramolecular helical chain. Compound 4 adopts a skew‐trapezoidal bipyramidal geometry with the organo groups lying over the plane of the two N,O‐chelating carboxylate ligands and being directed over the weaker Sn―N bonds. The in vitro antimicrobial activities of 1–4 against a Gram‐positive bacteria strain (Bacillus subtilis), a Gram‐negative bacteria strain (Escherichia coli) and against Candida albicans were studied and compared with the antimicrobial activities of Ph2SnL2 and Me2SnL2, and with the antimicrobial standards gentamicin, tetracycline, ampicillin and penicillin. All organotin compounds displayed remarkable antibacterial activities that were comparable to those of the standard drugs, in particular against B. subtilis, where the activity was correlated with the number of Cl substituents. Copyright © 2012 John Wiley & Sons, Ltd.
Forgiveness as Transitional Experience: A Winnicottian Approach
Authors: Alford C. Fred
Published: August 2012

A number of psychoanalysts, beginning with Freud, are skeptical about forgiveness, arguing that in the dynamic unconscious we never forgive nor forget. Some psychoanalysts worry that forgiveness risks becoming a shortcut to the hard work of grief and mourning. D. W. Winnicott offers a different perspective on forgiveness. Forgiveness happens not as a matter of conscious choice, but when we have reached that transitional space where we no longer need to hold onto our anger and hurt. Forgiveness, from this perspective, is something that happens at a certain stage virtually as a byproduct of living in the world in a certain way. What that way is, and the role that community plays in facilitating that way, are considered. Copyright © 2012 John Wiley & Sons, Ltd.
Distribution of Adenylyl Cyclases in the Rat Ovary by Immunofluorescence Microscopy
Authors: Bagavandoss P. , Grimshaw S.
Published: August 2012

In the mammalian ovary both gonadotropins and local cytokines, acting through G‐protein coupled receptors, govern the physiology of the ovary in part by regulating the cyclic adenosine 3′,5′‐monophosphate via adenylyl cyclases. The nine transmembrane adenylyl cyclases and a soluble adenylyl cyclase are regulated by a diversity of ligands. In this study we have examined the rat ovaries, prior to and subsequent to gonadotropin treatment, for the presence of different transmembrane adenylyl cyclases by indirect immunofluorescence microscopy. Adenylyl cyclase I immunoreactivity was observed in the nuclei of oocytes in preantral and antral follicles along with some staining in granulosa cells. Equine chorionic gonadotropin injection increased adenylyl cyclase I staining in granulosa cells. Adenylyl cyclase I staining was also observed in luteal and endothelial cells. Adenylyl cyclase II was observed throughout the ovary, including granulosa cells and the ovarian surface epithelium. Adenylyl cyclase II staining was also found to increase in granulosa cells after equine chorionic gonadotropin injection. Adenylyl cyclase III was distributed primarily in theca and smooth muscle cells of arterioles, with faint staining in the oocytes of equine chorionic gonadotropin‐injected ovaries. Adenylyl cyclase IV staining was present throughout the ovary, including the nuclei of oocytes. Adenylyl cyclase VIII staining in granulosa cells increased subsequent to equine chorionic gonadotropin injection and remained in luteal cells. Our study reveals the redundancy of adenylyl cyclases present in the rat ovary and, therefore, implies potential regulation of follicular and corpus luteum physiology by cyclic adenosine 3′,5′‐monophosphate generated through distinct adenylyl cyclases. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
IN VITRO ANTIVIRAL ACTIVITY OF AN ALKALINE TRYPSIN FROM THE DIGESTIVE JUICE OF Bombyx mori LARVAE AGAINST NUCLEOPOLYHEDROVIRUS
Authors: Ponnuvel Kangayam M. , Nithya Krishnappa , Sirigineedi Sasibhushan , Awasthi Arvind K. , Yamakawa Minoru
Published: August 2012

Alkaline trypsin protein of molecular mass 25,436 Da purified from the digestive juice of Bombyx mori larvae indicated strong antiviral activity against Bombyx mori nucleopolyhedrovirus (BmNPV) under in vitro conditions. Partial N‐terminal amino acid sequence of the protein was determined and the cDNA was cloned based on the amino acid sequence. A homology search of the deduced amino acid sequence of the cDNA showed 55% identity with Helicoverpa armigera trypsin and the active site of this protein was completely conserved. Hence, the protein was designated B. mori trypsin (Bmtryp). The results suggest that Bmtryp, an insect digestive enzyme, can be a potential antiviral factor against BmNPV at the initial site of viral infection.
RNA INTERFERENCE OF BROAD GENE EXPRESSION MIMICS ANTIMETAMORPHIC EFFECT OF PYRIPROXYFEN ON THE BEET ARMYWORM, Spodoptera exigua
Authors: Kim Jiwan , Kim Yonggyun
Published: August 2012

A larva‐to‐pupa metamorphosis is induced by a low or undetectable level of juvenile hormone (JH) during last instar in holometabolous insects. An exogenous application of JH agonist, pyriproxyfen (PYR), inhibited pupal metamorphosis of the beet armyworm, Spodoptera exigua. Last instar larvae of S. exigua exhibited increase of body size at first 3 days along with active feeding behavior. Also, at this period, prothoracic gland increased in size, while corpora allata remained little change. Storage proteins were accumulated in hemolymph plasma from penultimate to last instars, during which two storage protein genes (SeHex and SeSP1) were actively expressed. A Broad‐Complex 1 (BRC1) gene of S. exigua (SeBRC1) was partially cloned and showed a specific expression at the last instar in all tested tissues including hemocytes, fat body, epidermis, gut, nerve, and salivary gland. Knockdown of SeBRC1 expression by its specific double‐strand RNA mimicked the antimetamorphic effect induced by PYR treatment. PYR treatment at early last instar inhibited expression of SeBRC1, but did not that of other nuclear receptor, βFTZ‐F1. These results indicate that a transcriptional factor, SeBRC1, plays a crucial role in pupal metamorphosis of S. exigua.
On Trajectory Tracking Model Predictive Control of an Unmanned Quadrotor Helicopter Subject to Aerodynamic Disturbances
Authors: Alexis K. , Nikolakopoulos G. , Tzes A.
Published: August 2012

In this article a model predictive control (MPC) strategy for the trajectory tracking of an unmanned quadrotor is presented. The quadrotor's dynamics are modeled using a hybrid systems approach and, specifically, a set of piecewise affine (PWA) systems around different operating points of the translational and rotational motions. The proposed control scheme is dual and consists of an integral MPC for the translational motions, followed by an MPC scheme for the tracking of the quadrotor's attitude motions. By the utilization of PWA representations, the controller is computed for a larger part of the quadrotor's flight envelope, which provides more control authority for aggressive maneuvering. The proposed dual control scheme is able to calculate optimal control actions with robustness against atmospheric disturbances (e.g. wind gusts) and with respect to the physical constraints of the quadrotor (e.g. maximum lifting forces or fixed thrust limitations in order to extend flight endurance). Extended simulation studies indicate the efficiency of the MPC scheme, both in trajectory tracking and aerodynamic disturbance attenuation.
Comparative analyses of laccase‐catalyzed amination reactions for production of novel β‐lactam antibiotics
Authors: Mikolasch Annett , Manda Katrin , Schlüter Rabea , Lalk Michael , Witt Sabine , Seefeldt Simone , Hammer Elke , Schauer Frieder , Jülich Wolf‐Dieter , Lindequist Ulrike
Published: August 2012

Seven novel β‐lactam antibiotics with activities against Gram‐positive bacterial strains, among them methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant enterococci, were synthesized by amination of 2,5‐dihydroxyphenylacetic acid in usable yields (30–60%). These products protected mice against an infection with S. aureus lethal to the control animals. The results show the usefulness of laccase for the synthesis of potential new antibiotics, in addition to the interdependence of the laccase substrates, the amino coupling partners, and the product formation, yield, and activity. The syntheses of β‐lactam antibiotics with 2,5‐dihydroxyaromatic acid substructures (para‐substituted) are then compared with those of 3,4‐dihydroxyaromatic acid substructures (ortho‐substituted). Para‐substituted laccase substrates were better reaction partners in these syntheses than ortho‐substituted compounds.
Applying high‐throughput methods to develop a purification process for a highly glycosylated protein
Authors: Sanaie Nooshafarin , Cecchini Douglas , Pieracci John
Published: August 2012

Micro‐scale chromatography formats are becoming more routinely used in purification process development because of their ability to rapidly screen large number of process conditions at a time with minimal material. Given the usual constraints that exist on development timelines and resources, these systems can provide a means to maximize process knowledge and process robustness compared to traditional packed column formats. In this work, a high‐throughput, 96‐well filter plate format was used in the development of the cation exchange and hydrophobic interaction chromatography steps of a purification process designed to alter the glycoform distribution of a small protein. The significant input parameters affecting process performance were rapidly identified for both steps and preliminary operating conditions were identified. These ranges were verified in a packed chromatography column in order to assess the ability of the 96‐well plate to predict packed column performance. In both steps, the 96‐well plate format consistently led to underestimated glycoform‐enrichment levels and to overestimated product recovery rates compared to the column‐based approach. These studies demonstrate that the plate format can be used as a screening tool to narrow the operating ranges prior to further optimization on packed chromatography columns.
Synthesis of Multifunctional Metal‐ and Metal Oxide Core@Mesoporous Silica Shell Structures by Using a Wet Chemical Approach
Authors: Kim Chang Woo , Pal Umapada , Park Sangji , Kim Jinheung , Kang Young Soo
Published: August 2012

We demonstrate a facile wet chemical approach for fabricating spherical metal/metal‐oxide core@mesoporous silica shell hybrid nanoparticles with different core and shell thicknesses. Vertically aligned mesoporous silica (mSiO2) shells were fabricated over the pre‐synthesized spherical SiO2 nanoparticles through a three‐step strategy: 1) synthesis of core materials, 2) covering the core with an organic–inorganic composite layer, and 3) removing the organic template through calcinations in air. The mechanisms of hybrid structure formation are proposed. The multifunctional nature of the hybrid structures could be induced by incorporating guest ions/molecules, such as Ag, Mn, and TiO2, into the pores of an mSiO2 shell. Mn and TiO2 cluster‐ incorporated composite structures have been tested to be antioxidizing agents and effective photocatalysts through electron spin resonance, radical scavenging tests, and the photocatalytic degradation of rhodamine B. The possibility of incorporating several hetero‐element guest clusters in these mesoporous composite particles makes them highly attractive for multifunctional applications.
ChemInform Abstract: Crystal Structure and Magnetism of Gd5‐xEuxGe4.
Authors: Yao Jinlei , Wang Peng L. , Mozharivskyj Yurij
Published: August 2012

The title compounds (0 < x < 3.0) and Y3Eu2Ge4 are prepared from the elements (Ta ampules, 1200—1300 °C, 13—15 h) and characterized by powder and single crystal XRD, magnetization measurements, and TB‐LMTO‐ASA calculations.
ChemInform Abstract: The Thermal Stability and Structural Site‐Distribution of Eu3+ Ions in the Red‐Emitting Phosphors Ca9Eu2W4O24 and Sr9Eu2W4O24.
Authors: Qin Chuanxiang , Huang Yanlin , Seo Hyo Jin
Published: August 2012

The red‐emitting title phosphors are synthesized by solid state reaction of stoichiometric mixtures of Eu2O3, CaCO3 or SrCO3, and WO3 (corundum crucible, 850, 1100, and 1350 °C for 10 h in air).
ChemInform Abstract: Effect of H3BO3 on the Low Temperature Sintering and Microwave Dielectric Properties of Li2ZnTi3O8 Ceramics.
Authors: Zhang Ping , Hua Yanbo , Xia Wangsuo , Li Lingxia
Published: August 2012

Li2ZnTi3O8 ceramics sintered at 880 °C with 1.0 wt.% H3BO3 addition show excellent microwave dielectric properties with a dielectric constant of 25.9, Q x f = 50200 GHz, and τf = ‐6.8 ppm/°C.
ChemInform Abstract: Peculiar Field‐Dependent Magnetic Behavior of Cyano‐Bridged Coordination Polymer Er(H2O)4[W(CN)8].
Authors: Perrier Marine , Long Jerome , Ameida Paz Filipe A. , Guari Yannick , Larionova Joulia
Published: August 2012

Crystals of Er(H2O)4[M(CN)8] (M: W, Mo) are prepared by slow diffusion of diethyl ether into an acetonitrile solution of [NBu4]3[M(CN)8] and [Er(H2O)5](NO3)3.
ChemInform Abstract: Prussian Blue: A New Framework of Electrode Materials for Sodium Batteries.
Authors: Lu Yuhao , Wang Long , Cheng Jinguang , Goodenough John B.
Published: August 2012

KMFe(CN)6 (M: Mn, Fe, Co, Nu, Zn) Prussian blue analogues are synthesized at room temperature by addition of M(II) salt solutions to K3Fe(CN)6 solution (ultrasound, stirring, 2 h).
ChemInform Abstract: Highly Dispersed Platinum Nanoparticles on TiO2 Prepared by Using the Microwave‐Assisted Deposition Method: An Efficient Photocatalyst for the Formation of H2 and N2 from Aqueous NH3.
Authors: Fuku Kojirou , Kamegawa Takashi , Mori Kohsuke , Yamashita Hiromi
Published: August 2012

Pt—TiO2 nanoparticles are prepared by microwave‐assisted deposition from an aqueous suspension of H2PtCl6 and TiO2 irradiated with microwaves followed by reduction with H2 at 473 K for 2 h.
ChemInform Abstract: Mg3[M(CN)6]2·xH2O with M: Fe, Co: Synthesis, Crystal Structure, and Hydrogen Sorption.
Authors: Jimenez‐Gallegos Juan , Roque Jorge , Yee‐Madeira Hernani , Reguera Edilso
Published: August 2012

The title compounds are prepared by neutralization of aqueous solutions of H3[M(CN)6] (M: Fe, Co) with Mg(OH)2 followed by evaporation of the solvent.
ChemInform Abstract: Synthesis and Crystal Structure of Ca(en)4Ca(en)3[Sn2Se6] and Ca(en)4Se4 in Superheated and Supercritical Ethylenediamine.
Authors: Menezes Prashanth W. , Faessler Thomas F.
Published: August 2012

Compounds (IV) and (VI) are synthesized under superheated (443 K) and supercritical (573 K) solvothermal conditions, resp., and characterized by single crystal XRD.
ChemInform Abstract: Aqueous Compatibility of Group IIIA Monomers and Nb‐Polyoxoanions.
Authors: Hou Yu , Alam Todd M. , Rodriguez Mark A. , Nyman May
Published: August 2012

Four compounds containing the new heteropolyanions [GaNb18O54]15‐ and [AlNb18O54]15‐ are synthesized.
ChemInform Abstract: Facile Molten Salt Synthesis of Ordered Perovskite Ba(Sr1/3Nb2/3)O3 Powders.
Authors: Deng Jinxia , Li Lihong , Chen Jun , Yu Ranbo , Xing Xianran
Published: August 2012

The title compound is prepared by a molten salt synthesis method starting with a stoichiometric mixture of BaCO3, SrCO3, and Nb2O5, and a 10 fold excess of NaCl (grinding of reactants with EtOH, drying, reaction at 1030 °C, 2 h).
ChemInform Abstract: Hydrothermal Synthesis and Crystal Structure of a Novel Rare‐Earth Tungsten Phosphate Supramolecular Compound.
Authors: Shu Qi‐Xia , Sun Guo‐Yuan , Wang Xiao‐Bo , Hu Xue‐Lei
Published: August 2012

Light green crystals of (H2bpy)2 [Eu(H2O)3(PW11O39)] ·6H2O (bpy: 4,4′‐bipyridine) are hydrothermally synthesized from a mixture of Na2WO4, Na2HPO4, Eu2O3, bpy, and H2O (pH 4 adjusted with HNO3, 170 °C, autoclave, 5 d).
ChemInform Abstract: Synthesis and Characterization of the New Mixed Valent Compound Mn5VO8.
Authors: Clemens Oliver , Haberkorn Robert , Kohlmann Holger , Springborg Michael , Beck Horst Philipp
Published: August 2012

The new title compound is prepared by solid state reaction of MnO, Mn2O3, and V2O5 (pressed pellet, flowing Ar, 900 °C, 20 h) and characterized by powder X‐ray and neutron diffraction.
ChemInform Abstract: Enantioselective Direct Aminalization with Primary Carboxamides Catalyzed by Chiral Ammonium 1,1′‐Binaphthyl‐2,2′‐disulfonates.
Authors: Hatano Manabu , Ozaki Takuya , Sugiura Yoshihiro , Ishihara Kazuaki
Published: August 2012

The enantioselective addition of amides (II) to aldimines (I) proceeds readily in the presence of in situ prepared salts of (R)‐1,1′‐binaphthyl‐2,2′‐disulfonic acid with achiral amines.
ChemInform Abstract: Highly Enantioselective Proline‐Catalyzed Direct Aldol Reaction of Chloroacetone and Aromatic Aldehydes.
Authors: Martinez‐Castaneda Angel , Poladura Belen , Rodriguez‐Solla Humberto , Concellon Carmen , del Amo Vicente
Published: August 2012

Direct aldol reaction of chloroacetone with aromatic aldehydes proceeds smoothly in the presence of a chiral L‐proline—triazabicyclodecene catalyst to afford the anti‐chlorohydrins (III) in high to excellent regio‐ and stereoselectivities (up to 88% d.e.
ChemInform Abstract: Structure—Reactivity Studies of Simple 4‐Hydroxyprolinamide Organocatalysts in the Asymmetric Michael Addition Reaction of Aldehydes to Nitroolefins.
Authors: Watts John , Luu Lien , McKee Vickie , Carey Ed , Kelleher Fintan
Published: August 2012

From a series of 15 4‐hydroxyprolinamides compounds (I) show promising activity as catalysts in the title reaction.
ChemInform Abstract: Synthesis and Antioxidant and Antitumor Activity of Novel Pyridine, Chromene, Thiophene and Thiazole Derivatives.
Authors: Fadda Ahmed A. , Berghot Moged A. , Amer Fathy A. , Badawy Doria S. , Bayoumy Nesma M.
Published: August 2012

Compounds (IV) and (V) exhibit potent antioxidative activity.
ChemInform Abstract: CuBr‐Catalyzed Oxidative Desulfurization of Thiobenzamides.
Authors: Cheng Dongping , Sun Ruirui , Yan Jizhong
Published: August 2012

Oxidative desulfurization of secondary or tertiary thioamides (I) provides access to the corresponding amides, while primary thioamides (III) undergo cyclization to afford thiadiazoles (IV).
ChemInform Abstract: Heterogeneously Catalyzed Selective Aerobic Oxidative Cross‐Coupling of Terminal Alkynes and Amides with Simple Copper(II) Hydroxide.
Authors: Jin Xiongjie , Yamaguchi Kazuya , Mizuno Noritaka
Published: August 2012

A variety of ynamides is readily obtained by a copper‐catalyzed cross‐coupling of alkynes (I) with corresponding oxazolidinones (II) and (IV), azetidinone (VI), or sulfonamide (VIII).
ChemInform Abstract: Synthesis of Hindered Anilines: Copper‐Catalyzed Electrophilic Amination of Aryl Boronic Esters.
Authors: Rucker Richard P. , Whittaker Aaron M. , Dang Hester , Lalic Gojko
Published: August 2012

A mild and new method for the title synthesis is developed.
ChemInform Abstract: A Versatile Rhodium(I) Catalyst System for the Addition of Heteroarenes to Both Alkenes and Alkynes by a C—H Bond Activation.
Authors: Ryu Jaeyune , Cho Seung Hwan , Chang Sukbok
Published: August 2012

For the first time, the facile regio‐ and stereoselective title reaction is described.
ChemInform Abstract: Nickel‐Mediated Inter‐ and Intramolecular Reductive Cross‐Coupling of Unactivated Alkyl Bromides and Aryl Iodides at Room Temperature.
Authors: Yan Chang‐Song , Peng Yu , Xu Xiao‐Bo , Wang Ya‐Wen
Published: August 2012

In situ generated [Ni0(ethyl crotonate)2·py] complexes are successfully applied for a series of inter‐ and intramolecular reductive cross‐coupling reactions under exceptionally mild conditions.
ChemInform Abstract: Diastereoselective Reductive Nitro‐Mannich Reactions.
Authors: Anderson James C. , Blake Alexander J. , Koovits Paul J. , Stepney Gregory J.
Published: August 2012

The efficient, widely applicable, and highly diastereoselective method affords β‐nitroamines which can be converted into 1,2‐diamines.
ChemInform Abstract: Replacing Conventional Carbon Nucleophiles with Electrophiles: Nickel‐Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides.
Authors: Everson Daniel A. , Jones Brittany A. , Weix Daniel J.
Published: August 2012

Under optimized conditions, a variety of aryl/heteroaryl bromides, aryl chlorides, and vinyl bromides is reductively coupled with alkyl bromides to give alkylated arenes.
ChemInform Abstract: Visible‐Light‐Promoted Stereoselective Alkylation by Combining Heterogeneous Photocatalysis with Organocatalysis.
Authors: Cherevatskaya Maria , Neumann Matthias , Fueldner Stefan , Harlander Christoph , Kuemmel Susanne , Dankesreiter Stephan , Pfitzner Arno , Zeitler Kirsten , Koenig Burkhard
Published: August 2012

The easily available inorganic semiconductors (photocatalysts) can be simply removed and recycled.
ChemInform Abstract: Magnetic Nanoparticles‐Supported Palladium: A Highly Efficient and Reusable Catalyst for the Suzuki, Sonogashira, and Heck Reactions.
Authors: Li Pinhua , Wang Lei , Zhang Lei , Wang Guan‐Wu
Published: August 2012

A highly air‐ and moisture‐stable supported Pd catalyst is prepared by reaction of palladium acetate with phosphinylethyl‐functionalized silica‐coated Fe3O4 nanoparticles.
ChemInform Abstract: Palladium(II) Containing γ‐Keggin Silicodecatungstate that Efficiently Catalyzes Hydration of Nitriles.
Authors: Hirano Tomohisa , Uehara Kazuhiro , Kamata Keigo , Mizuno Noritaka
Published: August 2012

The crystal structure of the title catalyst is a monomeric, dipalladium‐substituted, γ‐Keggin silicodecatungstate with bidentate acetate ligands.
ChemInform Abstract: Broensted Acidic Ionic Liquids: Green, Efficient and Reusable Catalyst for Synthesis of Fluorinated Spiro [Indole‐Thiazinones/Thiazolidinones] as Antihistamic Agents.
Authors: Arya Kapil , Rawat Diwan Singh , Dandia Anshu , Sasai Hiroaki
Published: August 2012

The ionic liquids are used both as catalysts and reaction medium for the synthesis of spiro compounds (IV) and (VI) in a one‐pot environmentally benign microwave‐assisted process.
ChemInform Abstract: Copper‐Catalyzed Trifluoromethylation of Allylsilanes.
Authors: Shimizu Ryo , Egami Hiromichi , Hamashima Yoshitaka , Sodeoka Mikiko
Published: August 2012

The reaction is performed using Togni′s reagent (II) and CuI as catalyst.
ChemInform Abstract: Catalytic Enantioselective N‐Nitroso Aldol Reaction of γ,δ‐Unsaturated δ‐Lactones.
Authors: Yanagisawa Akira , Fujinami Takeo , Oyokawa Yu , Sugita Takuya , Yoshida Kazuhiro
Published: August 2012

The chiral tin bromide CTB promotes the reaction with δ‐lactones to produce α‐hydroxyamino ketones with up to 99% e.e.
ChemInform Abstract: Enantioselective Hydrosilylation with Chiral Frustrated Lewis Pairs.
Authors: Chen Dianjun , Leich Valeri , Pan Fangfang , Klankermayer Juergen
Published: August 2012

The asymmetric hydrosilylation of a variety of aromatic imines is efficiently achieved using a novel chiral frustrated Lewis pair catalyst (I).
ChemInform Abstract: One‐Pot Synthesis of Phenols by Hydroxylation of Aromatics with Hydroxylamine.
Authors: Zhang Dongsheng , Gao Liya , Xue Wei , Zhao Xinqiang , Wang Shufang , Wang Yanji
Published: August 2012

Benzene (I), ethylbenzene and xylenes, e.g. (IV), are hydroxylated with hydroxylamine to give phenols along with the corresponding anilines.
ChemInform Abstract: O‐Acetylation: Synthesis of Acetylated Phenols from Aryl‐Methyl Ethers over Boron Alkoxides.
Authors: Balaydin Halis T.
Published: August 2012

Demethylation of aryl methyl ethers and subsequent acetylation of the resulting boronic acid intermediates is successfully applied to directly afford acetoxybenzene derivatives.
ChemInform Abstract: A New Synthetic Route for Axially Chiral Secondary Amines with Binaphthyl Backbone and Their Applications in Asymmetric Michael Reaction of Aldehydes to Nitroalkenes.
Authors: Liang Da‐Cheng , Luo Ren‐Shi , Yin Li‐Hua , Chan Albert S. C. , Lu Gui
Published: August 2012

The practical application of the most effective novel binaphthyl‐based secondary amines in the title reaction is demonstrated.
ChemInform Abstract: Palladium Catalyzed Carbonylative Heck Reaction Affording Monoprotected 1,3‐Ketoaldehydes.
Authors: Goegsig Thomas M. , Nielsen Dennis U. , Lindhardt Anders T. , Skrydstrup Troels
Published: August 2012

The target compounds are useful synthons for heterocycles such as pyrazoles, isoxazoles, and pyrimidines.
ChemInform Abstract: Catalyst‐Free Aza‐Michael Addition of Azole to β,γ‐Unsaturated‐α‐keto Ester: An Efficient Access to C—N Bond Formation.
Authors: Wang Jun , Li Peng‐Fei , Chan Sau Hing , Chan Albert S. C. , Kwong Fuk Yee
Published: August 2012

The method allows the access to various N‐heterocyclic scaffolds as precursors of complex systems.
ChemInform Abstract: Cs2CO3 in Pyrrolidinone Promoted Hydration of Functionalized (Hetero)aryl Nitriles under Metal‐Free Conditions.
Authors: Sahnoun Sophian , Messaoudi Samir , Peyrat Jean‐Francois , Brion Jean‐Daniel , Alami Mouad
Published: August 2012

Optimized conditions are developed for the conversion of aryl and hetaryl nitriles into the corresponding amides.
ChemInform Abstract: Efficient and Alternative Approach for Preparation of O‐Benzoyloximes Using Benzoyl Peroxide.
Authors: Kundu Shrishnu Kumar , Rahman Matiur , Dhara Paritosh , Hajra Alakananda , Majee Adinath
Published: August 2012

The reaction of a variety of oximes with benzoyl peroxide is conducted under base‐free conditions.
ChemInform Abstract: A Metal‐Free Oxidative Esterification of the Benzyl C—H Bond.
Authors: Feng Jie , Liang Shuai , Chen Shan‐Yong , Zhang Ji , Fu Song‐Sen , Yu Xiao‐Qi
Published: August 2012

Oxidative esterification of benzylic C—H bonds with a wide variety of aromatic and aliphatic carboxylic acids proceeds smoothly by use of tert‐butyl hydroperoxide in the presence of catalytic amounts of tetrabutylammonium iodide.
ChemInform Abstract: TiCl4‐Catalyzed Synthesis of Peroxyacetals from Aldehydes.
Authors: Tsai Chen‐Yu , Chen Lu‐An , Sung Kuangsen
Published: August 2012

A novel and chemoselective methodology for the synthesis of the title compounds is developed.
ChemInform Abstract: Unprecedented Synthesis of Iron—NHC Complexes by C—H Activation of Imidazolium Salts. Mild Catalysts for Reduction of Sulfoxides.
Authors: Cardoso Joao M. S. , Royo Beatriz
Published: August 2012

A novel bidentate iron complex is prepared, which efficiently catalyzes the reduction of sulfoxides (I) with phenylsilane under mild conditions.
ChemInform Abstract: Efficient Copper(I)‐Catalyzed S‐Arylation of KSCN with Aryl Halides in PEG‐400.
Authors: Li Xiaokang , Yuan Tangjun , Chen Junmin
Published: August 2012

Aryl iodides can be used as well.
ChemInform Abstract: Palladium‐Catalyzed S‐Benzylation of Unprotected Mercaptobenzoic Acid with Benzyl Alcohols in Water.
Authors: Hikawa Hidemasa , Yokoyama Yuusaku
Published: August 2012

A new method for the title synthesis is presented.
ChemInform Abstract: Unprecedented Dithiolation of Enals via Their NHC‐Catalyzed Umpolung Reaction with Organic Disulfides.
Authors: Singh Santosh , Yadav Lal Dhar S.
Published: August 2012

A novel and atom economical procedure for the synthesis of the compounds (III), (V), and (VII) is presented.
ChemInform Abstract: Chiral Phosphoric Acid‐Catalyzed Asymmetric Oxidation of Aryl Alkyl Sulfides and Aldehyde‐Derived 1,3‐Dithianes: Using Aqueous Hydrogen Peroxide as the Terminal Oxidant.
Authors: Liu Zhao‐Min , Zhao Hua , Li Mei‐Qiu , Lan Yu‐Bao , Yao Qi‐Bo , Tao Jing‐Chao , Wang Xing‐Wang
Published: August 2012

The present protocol proceeds by a direct, enantioselective sulfoxidation process and not by kinetic resolution.
ChemInform Abstract: Copper‐Catalyzed C‐Alkylation of Secondary Alcohols and Methyl Ketones with Alcohols Employing the Aerobic Relay Race Methodology.
Authors: Liao Shiheng , Yu Kangkang , Li Qiang , Tian Haiwen , Zhang Zhengping , Yu Xiaochun , Xu Qing
Published: August 2012

A practical and advantageous ligand‐free method for the title reaction is developed by using simple alcohols and green alkylating substrates.
ChemInform Abstract: Cascade Synthesis of Bis‐N‐sulfonylcyclobutenes via Cu(I)/Lewis Acid‐Catalyzed (3 + 2)/(2 + 2) Cycloadditions: Observation of Aggregation‐Induced Emission Enhancement from Restricted C=N Photoisomerization.
Authors: Namitharan Kayambu , Pitchumani Kasi
Published: August 2012

Aliphatic sulfonyl azides or aliphatic alkynes give no products.
ChemInform Abstract: Cu(I)‐Catalyzed Annulation for the Synthesis of Substituted Naphthalenes Using o‐Bromobenzaldehydes and β‐Ketoesters as Substrates.
Authors: Malakar Chandi C. , Sudheendran Kavitha , Imrich Hans‐Georg , Mika Sabine , Beifuss Uwe
Published: August 2012

A simple, mild, and efficient one‐pot synthesis of the title compounds from easily accessible starting materials is developed.
ChemInform Abstract: Rhodium/Copper‐Catalyzed Annulation of Benzimides with Internal Alkynes: Indenone Synthesis Through Sequential C—H and C—N Cleavage.
Authors: Li Bi‐Jie , Wang Hao‐Yuan , Zhu Qi‐Lei , Shi Zhang‐Jie
Published: August 2012

The title synthesis uses easily available benzimide derivatives as starting materials and involves an uncommon acylation of organorhodium(III), which is essential for the C‐H cleavage.
ChemInform Abstract: Simple Gold‐Catalyzed Synthesis of Benzofulvenes—gem‐Diaurated Species as “Instant Dual‐Activation” Precatalysts.
Authors: Hashmi A. Stephen K. , Braun Ingo , Noesel Pascal , Schaedlich Johannes , Wieteck Marcel , Rudolph Matthias , Rominger Frank
Published: August 2012

The product (VI) is unstable during the work‐up and the isolation.
ChemInform Abstract: Decarboxylative C—H Arylation of Benzoic Acids under Radical Conditions.
Authors: Seo Sangwon , Slater Mark , Greaney Michael F.
Published: August 2012

The reaction allows a new access to various fluorene derivatives.
ChemInform Abstract: A Bulky Biaryl Phosphine Ligand Allows for Palladium‐Catalyzed Amidation of Five‐Membered Heterocycles as Electrophiles.
Authors: Su Mingjuan , Buchwald Stephen L.
Published: August 2012

The novel bulky ligand (I) significantly facilitates the reaction of five‐membered heteroaryl bromides with aromatic, heteroaromatic, or aliphatic carboxylic amides.
ChemInform Abstract: Formal Alkylation of Allenes Through Highly Selective Radical Cyclizations of Allene‐enes.
Authors: Zeng Rong , Fu Chunling , Ma Shengming
Published: August 2012

The first example of the title reaction is presented by using the cheap, readily available, efficient and mild reagent and catalyst.
ChemInform Abstract: Tuning of Regioselectivity in Inorganic Iodide‐Catalyzed Alkylation of 2‐Methoxyfurans via Electronic and Steric Effects.
Authors: Chen Jie , Ni Shengjun , Ma Shengming
Published: August 2012

The appropriate choice of alkylating reagent and catalyst allows for regioselective alkylation of 2‐methoxyfurans at either the 3‐ or the 5‐position.
ChemInform Abstract: Chemistry of Polyhalogenated Nitrobutadienes. Part 11. ipso‐Formylation of 2‐Chlorothiophenes under Vilsmeier—Haack Conditions.
Authors: Vogt Eva‐Janina , Zapol'skii Viktor A. , Nutz Eva , Kaufmann Dieter E.
Published: August 2012

Substitution of the chloro group by CHO (ipso‐formylation) is observed when the thiophene derivatives (I) react under Vilsmeyer—Haack conditions.
ChemInform Abstract: Preparation of 4,7‐Dibromobenzo[b]thiophene as a Versatile Building Block and Synthetic Application to a Bis(ethynylthienyl)oligoarene System.
Authors: Yamamoto Takuya , Katsuta Hiroshi , Toyota Kozo , Iwamoto Takeaki , Morita Noboru
Published: August 2012

Benzo[b]thiophene and thieno[3,2‐b]thiophenes (II) and (IV) are prepared by AuCl‐catalyzed thiophene annulation from the corresponding tertbutylsulfanyl‐ethinyl derivatives (I) and (III).
ChemInform Abstract: The Use of Sulfur Ylides in the Synthesis of 3‐Alkyl(aryl)thio‐4‐trifluoromethylpyrroles from Mesoionic 4‐Trifluoroacetyl‐1,3‐oxazolium‐5‐olates.
Authors: Saijo Ryosuke , Kawase Masami
Published: August 2012

A novel synthesis of highly substituted pyrroles is achieved by reaction of mesoionic 1,3‐oxazolium‐5‐olates with a variety of S‐ylides.
ChemInform Abstract: Chiral Guanidine‐Catalyzed Asymmetric Direct Vinylogous Michael Reaction of α,β‐Unsaturated γ‐Butyrolactams with Alkylidene Malonates.
Authors: Yang Yang , Dong Shunxi , Liu Xiaohua , Lin Lili , Feng Xiaoming
Published: August 2012

A novel bifunctional guanidine catalyst is prepared and successfully applied in the asymmetric direct vinylogous Michael reaction of lactam (I) with malonates (II).
ChemInform Abstract: Ethynyl Benziodoxolones for the Direct Alkynylation of Heterocycles: Structural Requirement, Improved Procedure for Pyrroles, and Insights into the Mechanism.
Authors: Brand Jonathan P. , Chevalley Clara , Scopelliti Rosario , Waser Jerome
Published: August 2012

A full account on the recently briefly published title investigation is presented, containing an improved procedure for alkynylation of pyrroles using pyridine as an additive and the first examples for alkynylation of thiophenes.
ChemInform Abstract: Palladium‐Catalyzed Dehydrogenative β′‐Functionalization of β‐Keto Esters with Indoles at Room Temperature.
Authors: Leskinen Mikko V. , Yip Kai‐Tai , Valkonen Arto , Pihko Petri M.
Published: August 2012

The title reaction proceeds with high C‐3‐selectivity for the indole and β′‐selectivity for the β‐keto ester.
ChemInform Abstract: Catalytic Enantioselective Alkene Aminohalogenation/Cyclization Involving Atom Transfer.
Authors: Bovino Michael T. , Chemler Sherry R.
Published: August 2012

The title metal‐catalyzed reaction is reported for the first time.
ChemInform Abstract: PANI‐HBF4: A Reusable Polymer‐Based Solid Acid Catalyst for Three‐Component, One‐Pot Synthesis of 3‐Substituted Amino Methyl Indoles under Solvent‐Free Conditions.
Authors: Devi Chebrolu Lavanya , Rao Vaidya Jayathirtha , Palaniappan Srinivasan
Published: August 2012

The catalyst can be recycled by filtration and reused for at least six runs without loss of activity.
ChemInform Abstract: Synthesis and Pharmacological Evaluation of 3‐Amino‐1‐(5‐indanyloxy)‐2‐propanol Derivatives as Potent Dodium Channel Blockers for the Treatment of Stroke.
Authors: Seki Maki , Tsuruta Osamu , Aoyama Yukio , Soejima Aki , Shimada Hiroshi , Nonaka Hikaru
Published: August 2012

The 3‐amino‐1‐(5‐indanyloxy)‐2‐propanol derivative bearing a benzimidazole moiety (I) shows potent neuroprotective activity in a rat transient middle cerebral artery occlusion model and high binding affinity for neurotoxin receptor site 2 of the Na+ channels.
ChemInform Abstract: Benzylic Phosphates as Electrophiles in the Palladium‐Catalyzed Asymmetric Benzylation of Azlactones.
Authors: Trost Barry M. , Czabaniuk Lara C.
Published: August 2012

The phosphate leaving group and the reaction conditions are optimized for the different benzylic phosphates, depending on the electron‐density of the phenyl ring.
ChemInform Abstract: A Chiral Bis(betaine) Catalyst for the Mannich Reaction of Azlactones and Aliphatic Imines.
Authors: Zhang Wen‐Quan , Cheng Ling‐Feng , Yu Jie , Gong Liu‐Zhu
Published: August 2012

A new catalyst is successfully applied to the title synthesis.
ChemInform Abstract: Regio‐ and Stereocontrolled Introduction of Secondary Alkyl Groups to Electron‐Deficient Arenes Through Copper‐Catalyzed Allylic Alkylation.
Authors: Makida Yusuke , Ohmiya Hirohisa , Sawamura Masaya
Published: August 2012

In the title reaction allylic substrates with a carbonate or acetate leaving group instead of the phosphate group are not reactive.
ChemInform Abstract: Synthesis of 6‐Sulfamoylsaccharin and Study of Its Reactivity in Alkylation Reactions.
Authors: Ivanova E. M. , Simin E. Yu. , Vozny I. V. , Trapencieris P. , Zalubovskis R.
Published: August 2012

An improved method for the preparation of 6‐sulfamoylsaccharin (IV) is developed.
ChemInform Abstract: Environmental Friendly Azide‐Alkyne Cycloaddition Reaction of Azides, Alkynes, and Organic Halides or Epoxides in Water: Efficient “Click” Synthesis of 1,2,3‐Triazole Derivatives by Cu Catalyst.
Authors: Liu Jianming , Liu Muwen , Yue Yuanyuan , Yao Meihuan , Zhuo Kelei
Published: August 2012

For the conversion of (I) to (III) or (IV) to (V), respectively, copper(II) acetate can also be used.
ChemInform Abstract: Metal‐Catalyzed One‐Pot Synthesis of Tetrazines Directly from Aliphatic Nitriles and Hydrazine.
Authors: Yang Jun , Karver Mark R. , Li Weilong , Sahu Swagat , Devaraj Neal K.
Published: August 2012

The method is also applicable to various unactivated nitriles to give either symmetrical or unsymmetrical tetrazines.
ChemInform Abstract: InCl3‐Promoted a Novel Prins Cyclization for the Synthesis of Hexahydro‐1H‐furo[3,4‐c]pyran Derivatives.
Authors: Reddy B. V. Subba , Sreelatha Marepally , Kishore Ch. , Borkar Prashant , Yadav J. S.
Published: August 2012

A simple protocol allows the synthesis of cis‐fused hexahydrofuropyrans (III) as scaffolds of natural products.
ChemInform Abstract: Base‐Catalyzed Asymmetric Diels—Alder Reaction of 3‐Hydroxy‐2‐pyrone and Simple Aryl Vinyl Sulfoxide: Asymmetric Synthesis of Carbaketopyranoses.
Authors: Okamura Hiroaki , Urabe Fumiya , Hamada Toshiyuki , Iwagawa Tetsuo
Published: August 2012

The stereoselectivity is predominantly controlled by the catalyst and the conditions.
ChemInform Abstract: Cooperative Dienamine/Hydrogen‐Bonding Catalysis: Enantioselective Formal [2 + 2] Cycloaddition of Enals with Nitroalkenes.
Authors: Talavera Garazi , Reyes Efraim , Vicario Jose L. , Carrillo Luisa
Published: August 2012

The title synthesis is the first example of a cascade reaction involving the dienamine/iminium manifold.
ChemInform Abstract: Lewis Acid Catalyzed Intramolecular [4 + 2] and [3 + 2] Cross‐Cycloaddition of Alkynylcyclopropane Ketones with Carbonyl Compounds and Imines.
Authors: Bai Yu , Tao Weijie , Ren Jun , Wang Zhongwen
Published: August 2012

The Lewis acid‐regulated selective title cycloadditions are developed by using common starting materials and under mild conditions.
ChemInform Abstract: Electronically Unfavorable Addition of Electron‐Deficient Olefins to Isochromenylium Tetrafluoroborates Initiated by C‐1 O‐Glycosylation.
Authors: Yu Shu‐Yan , Hu Zhi‐Long , Zhang Hao , Wang Shaozhong , Yao Zhu‐Jun
Published: August 2012

The reaction between starting materials (I) and electron‐deficient alkenes is studied to yield polycyclic products diastereoselectively.
ChemInform Abstract: 2‐Amino‐3‐cyano‐4‐(5‐arylisoxazol‐3‐yl)‐4H‐chromenes: Synthesis and in vitro Cytotoxic Activity.
Authors: Akbarzadeh Tahmineh , Rafinejad Ali , Mollaghasem Javad Malekian , Safavi Maliheh , Fallah‐Tafti Asal , Pordeli Mahboobeh , Ardestani Sussan Kabudanian , Shafiee Abbas , Foroumadi Alireza
Published: August 2012

Starting material (I) is prepared from ethyl 2,4‐dioxo‐4‐arylbutonate in three steps.
ChemInform Abstract: Microwave‐Assisted C‐3 Selective Oxidative Radical Alkylation of Flavones.
Authors: Miranda Luis D. , et al. et al.
Published: August 2012

The reaction of flavones with free hydroxyl groups leads to a complex mixture of products.
ChemInform Abstract: Catalytic Method for Synthesis of Benzopyrano[3,2‐c]chromene‐6,8‐dione Derivatives by Heteropoly Acids.
Authors: Motamedi Radineh , Baghbani Saeede , Bamoharram Fatemeh F.
Published: August 2012

An environmentally friendly synthesis of title compounds becomes possible using heteropolyacid in boiling ethanol.
ChemInform Abstract: Facile Approach for the Synthesis of 2,3,4,9‐Tetrahydro‐1H‐xanthen‐1‐ones and 8,9,10,12‐Tetrahydro‐11H‐benzo[a]xanthen‐11‐ones via Trapping of o‐Quinone Methides.
Authors: Osyanin Vitaly A. , Ivleva Elena A. , Klimochkin Yuri N.
Published: August 2012

An efficient synthesis is readily achieved by trapping of o‐quinone methides, generated from o‐hydroxybenzyl alcohols (II) or o‐hydroxybenzylamines, e.g. (IV), with aminocyclohexenones (I).
ChemInform Abstract: Synthesis of Some New 1,4‐Dihydropyridine Derivatives Through a Facile One‐Pot Hantzsch Condensation Catalyzed by Triethylamine.
Authors: Ghalem Wassima , Boulcina Raouf , Debache Abdelmadjid
Published: August 2012

The reaction is conducted under solvent‐free conditions and has a simple work‐up procedure.
ChemInform Abstract: Design and Synthesis of 2‐Iminothiazolidin‐4‐one Moiety‐Containing Compounds as Potent Antiproliferative Agents.
Authors: Zhai Xin , Li Wei , Chen Dong , Lai Ruiwei , Liu Jun , Gong Ping
Published: August 2012

The highest antitumor activity is found for derivative (IVc).
ChemInform Abstract: Friedlaender Synthesis of Polysubstituted Quinolines and Naphthyridines Promoted by Propylphosphonic Anhydride (T3P®) under Mild Conditions.
Authors: Jida Mouhamad , Deprez Benoit
Published: August 2012

A new efficient and environmentally friendly synthesis of polysubstituted quinoline derivatives involves the propylphosphonic anhydride promoted reaction of o‐aminoaryl ketones, e.g. (I), with a wide variety of enolizable ketones (II), (IV) and (VI).
ChemInform Abstract: CDC Reactions of N‐Aryl Tetrahydroisoquinolines Using Catalytic Amounts of DDQ: C—H Activation under Aerobic Conditions.
Authors: Alagiri Kaliyamoorthy , Devadig Pradeep , Prabhu Kandikere R.
Published: August 2012

Cross dehydrogenative coupling of tetrahydroisoquinolines (I) and (VI) with enolizable ketones (II) and (IV) as well as phosphonates (VII), resp., proceeds efficiently in the presence of catalytic amounts of DDQ and AIBN (10 mol%).
ChemInform Abstract: Regioselective Reaction of 5,6‐Dialkyl‐2‐halopyridine‐3,4‐dicarbonitriles with Ammonia.
Authors: Maksimova V. N. , Ershov O. V. , Lipin K. V. , Eremkin A. V. , Nasakin O. E.
Published: August 2012

Reaction of the title compounds (I) with alcoholic ammonia provides selective access to pyrrolopyridine derivatives (II) or nucleophilic substitution products (III), depending on the conditions.
ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Enantioselective Three‐Component Povarov Reaction Using Cyclic Enethioureas as Dienophiles: Stereocontrolled Access to Enantioenriched Hexahydropyrroloquinolines.
Authors: Dagousset Guillaume , Retailleau Pascal , Masson Geraldine , Zhu Jieping
Published: August 2012

A two‐step route is given to cleave the N‐thiocarbamoyl group in (IVc).
ChemInform Abstract: Generation of 4‐Polyfluoroaryl Pyrrolo[1,2‐a]quinolines via C—H Bond Activation.
Authors: Ye Shengqing , Liu Jianping , Wu Jie
Published: August 2012

A series of 4‐substituted pyrrolo[1,2‐a]quinolines (III) is easily synthesized by a palladium‐catalyzed reaction of pyrroles (I) with fluoroarenes (II).
ChemInform Abstract: Efficient Synthesis of Pyrrolo[2,1‐a]isoquinoline and Pyrrole[1,2‐a]quinoline Derivatives via One‐Pot Two‐Step Metal‐Catalyzed Three‐Component Reactions.
Authors: Wu Lei , Sun Jing , Yan Chaoguo
Published: August 2012

Alternatively to dimethyl acetylenedicarboxylate (II), the corresponding diethyl esters can be used as well.
ChemInform Abstract: Regioselective Synthesis of Fused Azo‐Linked Pyrazolo[4,3‐e]pyridines Using Nano‐Fe3O4.
Authors: Nikpassand Mohammad , Zare Leila , Shafaati Tamila , Shariati Shahab
Published: August 2012

The reaction is conducted under environmentally benign conditions and has an easy work‐up procedure.
ChemInform Abstract: Efficient [5 + 1]‐Strategy for the Assembly of 1,8‐Naphthyridin‐4(1H)‐ones by Domino Amination/Conjugate Addition Reactions of 1‐(2‐Chloropyridin‐3‐yl) Prop‐2‐yn‐1‐ones with Amines.
Authors: Iaroshenko Viktor O. , Knepper Ingo , Zahid Muhammad , Kuzora Rene , Dudkin Sergii , Villinger Alexander , Langer Peter
Published: August 2012

A new approach for the synthesis of the title compounds is developed.