bluuebunny/crossref_metadata_2025 huggingface dataset:
Contextos de vulnerabilidade entre adolescentes do ensino fundamental de Uberaba/MG
Authors: Da Silveira Rodrigo Eurípedes , Santos Álvaro Da Silva
Published: October 2018

Estudo ecológico-exploratório, que objetivou descrever situações de vulnerabilidade entre 189 alunos de 7ªs e 8ªs séries de uma escola pública de Uberaba/MG. A iniciação sexual já havia ocorrido para 66,7% dos jovens e 40,5% não utilizavam métodos contraceptivos. O uso de álcool foi relatado por 66% dos garotos e 55,1% das meninas; e de drogas ilícitas, 38% e 25,8%, respectivamente. Tais resultados refletem a necessidade de ações de educação em saúde direcionada a adolescentes, com metodologias mais inclusivas e lúdicas, estimulando a reflexão crítica acerca de fatores de vulnerabilidade relacionados ao comportamento sexual, uso de bebidas alcóolicas e drogadição.Descritores: Adolescente, Vulnerabilidade, Educação em Saúde, Saúde Escolar.Contexts of vulnerability among adolescents of the elementary school of Uberaba/MGEcological and exploratory study, which aimed to describe situations of vulnerability among 189 students in 7th and 8th series of a public school in Uberaba/MG. The sexual initiation had already occurred to 66.7% and 40.5% did not use contraceptive methods. Alcohol use was reported by 66% of boys and 55.1% of girls; and illicit drugs, 38% and 25.8%, respectively. These results reflect the need of health education activities targeted at adolescents, more inclusive and methodologies with playful, stimulating the critical reflection about vulnerability factors related to sexual behavior, use of alcohol and drug addiction.Descriptors: Adolescent, Vulnerability, Health Education, Scholar Health.Contextos de vulnerabilidad entre los adolescentes de la escuela primaria de Uberaba/MGEstudio ecológico y exploratorio, cuyo objetivo fue describir situaciones de vulnerabilidad entre 189 estudiantes de 7 º y 8 º serie de una escuela pública en Uberaba/MG. La iniciación sexual ya había ocurrido a 66,7% de los jóvenes y 40,5% no usaban anticonceptivos. Lo consumo de alcohol fue reportado por 66% de los hombres y 55.1% de las niñas; y de drogas ilícitas, por 38% y 25,8%, respectivamente. Estos resultados reflejan la necesidad de actividades de educación en Salud, más inclusivos y con metodologías lúdicas dirigidas a adolescentes, estimulando la reflexión crítica sobre factores de vulnerabilidad relacionados a comportamiento sexual, uso de alcohol y drogadicción.Descriptores: Adolescente, Vulnerabilidad, Educación en Salud, Salud en la Escuela.
Errata
Authors: Em Foco Enf.
Published: October 2018

ErrataEnfermagem em Foco. 2012;3(3).Página 110.- Onde se lê : Luciane Faver. Aspectos éticos nas redes sociais de apoio no cuidado domiciliar à luz do pensamento complexo.- Leia-se: Luciane Favero. Aspectos éticos nas redes sociais de apoio no cuidado domiciliar à luz do pensamento complexo.- Onde se lê: 20/12/2012.- Leia-se: 20/12/2011.
Desafios para a introdução da CIPE® no ensino de Saúde Coletiva: Relato de Experiência
Authors: Oliveira Michele Dias da Silva , Rocha Barbara Souza , Bachion Maria Márcia
Published: October 2018

Trata-se do relato de experiência do ensino da Teoria de Orem e da CIPE® em uma disciplina da área de saúde coletiva na graduação em enfermagem. Estratégias desenvolvidas incluíram exposição oral dialogada sobre a Teoria Geral do Autocuidado e da CIPE® e sua aplicação no cuidado de enfermagem, além da sua utilização no ensino clínico no atendimento a pessoas com hanseníase, diabetes e hipertensão arterial, mediante a realização de consultas de enfermagem supervisionadas e apresentação de estudo de caso. A Teoria de Orem foi facilmente recebida, mas a CIPE® teve resistência inicial, superada ao término das atividades de práticas clínica.Descritores: Enfermagem em Saúde Comunitária, Terminologia, Vocabulário, Educação em Enfermagem.Challenges for implementing CIPE® in the Collective Health teaching: Experience ReportThis work describes the experience of the teaching of Orem's Theory and CIPE® (International Classification for Nursing Practice) in a subject of the collective health area in the undergraduate course of Nursing. The strategies developed comprised an speech on the General Theory of Self-Care and CIPE® and their application in the nursing care, besides their use in the clinical teaching in the service of people with Hansen's' disease, diabetes, and high blood pressure, through supervised nursing consultations and presentation of case study. The Orem's Theory was easily accepted; however CIPE® was originally seen with some resistance, which was overcome at the end of the clinical practice activities.Descriptors: Community Health Nursing, Terminology, Vocabulary, Nursing Education.Desafíos para la introducción de la CIPE® en la enseñanza de Salud Colectiva: Relato de ExperienciaSe trata del relato de experiencia de la enseñanza de la Teoría de Orem y de CIPE® en una disciplina del área de salud colectiva en la graduación en enfermería. Estrategias desarrolladas incluyeron exposición oral dialogada sobre la Teoría General del Autocuidado y de la CIPE® y su aplicación en el cuidado de enfermería, además de su utilización en la enseñanza clínica en la atención a personas con lepra, diabetes e hipertensión arterial, mediante la realización de consultas de enfermería supervisadas y la presentación de estudio de caso. La Teoría de Orem fue fácilmente recibida, pero la CIPE® sufrió resistencia inicial, superada al término de las actividades de práctica clínica.Descriptores: Enfermería en Salud Comunitaria, Terminología, Vocabulario, Educación en Enfermería.
Empresa Júnior: espaço criativo e empreendedor de ensino-aprendizagem na Enfermagem
Authors: Spagnof Carla Aparecida , Bastos Joana Melillo
Published: October 2018

Resumo: A Empresa Júnior (EJ) é uma das formas de ensino-aprendizagem na enfermagem, a fim de preparar indivíduos para aprender a aprender e conquistar um diferencial na sua carreira profissional. É uma estratégia de ensino criativa que possibilita a atualização e contribui na formação de profissionais empreendedores. Objetivou-se apresentar a EJ como um espaço criativo e empreendedor para o processo de ensino-aprendizagem dos alunos da Enfermagem e da área da saúde. A Arterial, EJ da Escola de Enfermagem da Universidade Federal de Minas Gerais (EE-UFMG), foi criada em 2008, com o objetivo de capacitar o futuro enfermeiro para desenvolver habilidades gerenciais e de liderança. Vários projetos foram realizados: realização de oficinas, eventos científicos e acadêmicos; ações de responsabilidade social; além de fixação de parcerias. A experiência do ensino do empreendedorismo constitui-se em um importante espaço de formação acadêmica, preparando os estudantes para serem profissionais de excelência no mercado de trabalho.Descritores: Gestão em Saúde, Enfermagem, Educação em Saúde.Junior Company: a creative and entrepreneurial space for teaching-learning in Nursing/HealthAbstract: The aim of this study was to analyze the study and research groups, of the nursing area, registered in the Directory of Research Groups of the National Council to Development Scientific and Technological, which have a line of research with emphasis on the elderly. This is a documentary research, held between August and October 2011, the analysis occurred by descriptive statistics, by frequency calculations. Were identified 51 groups, with highest concentration in the northeast, southeast and south. Glimpses the need of studies directed the elderly and the importance of the nurses participation in the study and research groups, which can contribute to strengthening and search for new knowledge in the subject investigated.Descriptors: Health Management, Nursing, health Education.Empresa Júnior: espacio creativo y emprendedor de enseñanza-aprendizaje en Enfermería/SaludResumen: El objectivo fue analizar los grupos de estúdio e investigación del área de enfermería, registrados en el directorio de Grupos de Investigación del Consejo Nacional de Desarrollo Científico y Tecnológico, que tienen uma línea de investigación con énfasis en los ancianos. Investigación documental realizada entre agosto y octubre de 2011, cuyo análisis fue mediante estadística descriptiva por medio de cálculos de frecuencia. Se identificaron 51 grupos con la mayor concentración en El Nordeste, Sudeste y Sur. Se vislumbra de la necesidad de estúdios a los ancianos y la importancia de la participación de las enfermeras en los grupos de estudio e investigación, que puede contribuir al fortalecimiento y la búsqueda de nuevos conocimientos en el tema investigado.Descriptores: Gestión en Salud, Enfermería, Educaión em Salud.
Perfil epidemiológico das internações pelo uso/abuso de drogas na região centro-oeste de Minas Gerais
Authors: De Oliveira Conrado Augusto Ferreira , Teixeira Geralda De Moraes , Silva Vanessa Pereira , Ferreira Leandro Santos , Machado Richardson Miranda
Published: October 2018

Resumo: O estudo teve como objetivo caracterizar a hospitalização pelo uso/abuso de drogas. Estudo retrospectivo e exploratório realizado com 6.380 pacientes. Como resultados as características predominantes foram sexo masculino, idade 31-40 anos; hospitalizado pelar própria família e com tempo de permanência superior a 60 dias.O principal financiador das internações foi o sistema de saúde pública com 4.142 (64,4%) internações pagas. Conclui-se que o uso/abuso de drogas gera um maior grau de dependência e resulta em uma maior dificuldade em alcançar e manter a recuperação Portanto é importante o diagnóstico precoce para evitar hospitalizações e a gravidade dos casos.Descritores: Usuários de Drogas, Internação, EnfermagemEpidemiological profile of admissions by the use/abuse of drugs in the central-west region of Minas GeraisAbstract:The study aimed to characterize the hospitalization by the use/abuse of drugs. Retrospective and exploratory study conducted of 6380 patients. As a result the predominant features were male, age 31-40 years; hospitalized by family own with and length of stay exceeding 60 days. The main funder of hospitalizations was the health public system with 4142 (64,4%) paid admissions. Conclusion: Concluded that the use/drug abuse generates a higher level of dependence and results in a greater difficulty in achieving and maintaining recovery Therefore is important the early diagnosis to prevent hospitalizations and severity of cases.Descriptors: Drug Users, Hospitalization, NursingPerfil epidemiológico de los ingresos por el uso y abuso de drogas en la región centro-oeste de Minas GeraisResumen: Caracterizar las hospitalizaciones por el uso/abuso de drogas. Métodos: estudio retrospectivo, exploratorio que incluyó 6380 pacientes. Resultados: las características predominantes fueram hombres, edad 31-40 años, llevados al hospital por la propia familia y la duración de la internación superior a 60 dias. La principal fuente de financiación del hospitalización fue el sistema de salud pública, con 4.142 (64,4%) ingresos pagados. Conclusión: el uso/abuso de drogas genera un mayor grado de dependencia y se traduce en una mayor dificultad para lograr y mantener la recuperación. Por lo tanto es importante el diagnóstico precoz para prevenir las hospitalizaciones y la gravedad de los casos.Descriptores: Drogas, Hospitalización, Enfermería
Sexualidade na terceira idade: conhecimento e comportamento de idosos residentes em um município de Minas Gerais
Authors: Souza e Souza Luís Paulo , Paulino Maria Cecília De Fátima Oliveira , Bernardes Claudinéia Alves , Silva Carla Silvana de Oliveira , Santana Jansen Maxwell De Freitas , Mota Écila Campos
Published: October 2018

Resumo: O estudo objetivou identificar comportamentos sexuais e conhecimento de idosos sobre doenças sexualmente transmissíveis. Pesquisa quantitativa e descritiva com idosos em Montes Claros, MG. Os dados foram coletados por meio de questionário. Dos 153 idosos pesquisados, 96 (63%) apresentaram parceria sexual fixa; 88 (57,5%) não tiveram relação sexual nos últimos seis meses; 120 (78,5%) não realizaram teste para HIV; 98 (64%) fizeram uso de preservativo na última relação sexual. O conhecimento dos idosos pesquisados sobre doenças sexualmente transmissíveis é deficiente, principalmente frente à baixa utilização de preservativos como forma de prevenção, estando com riscos aumentados às doenças sexualmente transmissíveis.Descritores: Idosos, Doenças Sexualmente Transmissíveis, Comportamento SexualSexuality in old age: knowledge and behavior of elderly residents in a municipality of Minas GeraisAbstract: The study aimed to identify sexual behaviors and knowledge of the elderly on sexually transmitted diseases. Quantitative and descriptive research with seniors in Montes Claros, MG. The data were collected through a questionnaire. Of the 153 seniors surveyed, 96 (63%) presented a fixed sexual partnership; 88 (57.5%) have not had sexual intercourse in the past six months; 120 (78.5%) not performed testing for HIV; 98 (64%) made use of a condom at last intercourse. Knowledge of seniors surveyed about sexually transmitted diseases is deficient, especially vis-à-vis the low use of condoms as a means of prevention, and with increased risks of sexually transmitted diseases.Descriptors: Aged, Sexually Transmitted Diseases, Sexual BehaviorSexualidad en la vejez: conocimiento y comportamento de las personas mayores que viven en un municipio de Minas GeraisResumen: El estudio pretende identificar los comportamientos sexuales y el conocimiento de las personas mayores en enfermedades de transmisión sexual. Investigación cuantitativa y descriptiva con las personas mayores en Montes Claros, MG. Los datos fueron recogidos a través de un cuestionario. De las 153 personas mayores encuestados, 96 (63%) presentó una asociación sexual fija; 88 (57,5%) no ha tenido relaciones sexuales en los últimos seis meses; 120 (78.5%) no realizada pruebas del VIH; 98 (64%) hizo uso de un condón en el último coito. Conocimiento de los estudiantes encuestados sobre enfermedades de transmisión sexual es deficiente, especialmente à frente el bajo uso del preservativo como medio de prevención y aumentado los riesgos de enfermedades de transmisión sexual. Conclusión: Contribuye a la generalización del conocimiento, es importante para la práctica, la formación y la investigación en enfermería.Descriptores: Anciano, Enfermedades de Transmisión Sexual, Conducta Sexual
Alterações de saúde e sintomas sugestivos de depressão entre trabalhadores da enfermagem do serviço de atendimento móvel de urgência
Authors: Antonio Mayara Caroline Ribeiro , Candi Mariluci Camargo Ferreira da Silva , Contrera Luciana , Duarte Sebastião Junior Henrique , Furegato Antonia Regina Ferreira , Pontes Elenir Rose Jardim Cury
Published: October 2018

Resumo: Objetivou-se relacionar as alterações de saúde com a prevalência de sintomatologia sugestiva de depressão dos profissionais da equipe deenfermagem do Serviço de Atendimento Móvel de Urgência. Estudo epidemiológico, descritivo e transversal, com abordagem quantitativa, realizadoentre julho e outubro de 2013. Participaram do estudo 85 profissionais de enfermagem. Os trabalhadores que indicaram serem portadores de transtornomental apresentaram prevalência de sintomatologia sugestiva de depressão quatro vezes maior quando comparada aos trabalhadores que não indicaramserem portadores dessa doença. Conclui-se que a associação entre a prevalência de sintomatologia sugestiva de depressão e o transtorno mentalsão fatores comprometedores ao bem estar profissional. Descritores: Transtornos mentais. Serviços médicos de emergência. Equipe de enfermagem.Changes in health and symptoms suggestive of depression among nursing staff of the mobile emergence care serviceAbstract: The aim of this work was relate changes in health with the prevalence of symptoms suggestive of depression in professionals of nursing staffof the Mobile Emergence Care Service. This is an epidemiological, descriptive and transversal study with a quantitative approach of the data, carriedout between July and October of 2013. The study included 85 professionals. Workers that indicated carrier of mental disorders had a prevalence ofsymptoms suggestive of depression four times higher when compared to workers that had no indicated carrier of this disease. We conclude that theassociation between the prevalence of symptoms suggestive of depression and mental illness are factors compromising the welfare professional.Descriptors: Mental disorders. Emergency medical services. Nursing team.Alteraciones de salud y síntomas sugestivos de depresión entre trabajadores de la enfermería del servicio de atención móvil de urgenciaResumen: El presente estudio tuvo como objetivo relacionar las alteraciones de salud com la prevalencia de síntomas sugestivos de depresión delos profesionales de la enfermeira del servicio de antención móvil de urgência. Se trata de un estudio epidemiológico, descriptivo y transversal, conabordagen cuantitativa de los datos, realizada entre Julio y Octubre de 2013. Participaron en el estudio 85 profesionales. Los trabajadores que indicaronque los pacientes con trastornos mentales presentan uma prevalencia de síntomas sugestivos de depresión cuatro veces mayor que los trabajadoresque no indican la enfermedad. La conclusión és de que la asociación entre la prevalencia de síntomas sugestivos de la depresión y la enfermedad mentalson factores que comprometen el bienestar profesional.Descriptores: Trastornos mentales. Servicios médicos de urgencia. Grupo de enfermería.
Dependente sim, viciado não: representações sociais de dependentes químicos
Authors: Da Silva Sílvio Éder Dias , Padilha Maria José Itayra , De Oliveira Jéssica Mayara Marques Barboza , Araujo Jeferson Santos , Barata Ingrid Mello , Da Cunha Natacha Mariana Farias , Alves Poliana Dos Santos , Vasconcelos Esleane Vilela
Published: October 2018

Resumo: Objetivou-se identificar e interpretar as Representações Sociais dos Dependentes Químicos sobre as Drogas, atendidos pela CasaMental Álcool e Drogas (Casa AD). Trata-se de um estudo do tipo descritivo, com abordagem qualitativa. Tem como aporte a Teoria das RepresentaçõesSociais criada por Serge Moscovici, constituída pelos depoimentos de 30 dependentes químicos produzidos a partir de entrevistasemiestruturada e da técnica de associação livre de palavras. Foi realizada análise temática. Os depoentes se sentiam afetados por tudo aquilo queaconteceu e/ou estava ainda acontecendo em suas vidas, mas o vício se faz presente, e emerge sensação de necessidade extrema do consumo.Descritores: Enfermagem, Saúde Mental, Entorpecentes.Dependent yes, not addicted: representations of drugAbstract: This study aimed to identify and interpret the social representations of chemical dependents About Drugs, Mental served by CasaAlcohol and Drugs (House AD). This is a descriptive study with a qualitative approach. Its contribution to the social representations theory createdby Serge Moscovici, comprising the testimonies of 30 drug produced from a semistructured interview and the technique of free association ofwords. Thematic analysis was performed. The respondents felt affected by everything that happened and / or was still happening in their lives,but addiction is present, and emerge feeling of extreme necessity consumption.Descriptors: Nursing, Mental Health, Narcotics.Dependiente sí, no addicted: representaciones de la drogaResumen: Este estudio tuvo como objetivo identificar e interpretar las representaciones sociales de Dependientes químicos sobre las Drogas,Alcohol mentales atendidos por Casa y Medicamentos (Anuncio). Se trata de un estudio descriptivo con un enfoque cualitativo. Su contribucióna la teoría de las representaciones sociales creado por Serge Moscovici, que incluye los testimonios de 30 medicamentos producidos a partirde una entrevista semiestructurada y la técnica de asociación libre de palabras. El análisis temático se realizó. Los encuestados se sintieronafectados por todo lo que pasó y / o que se siguen sucediendo en sus vidas, pero la adicción está presente, y surgen sentimientos de consumode extrema necesidad.Descriptores: Enfermería, Salud Mental, Narcóticos.
Percepção do surdo com diabetes mellitus sobre a assistência em saúde
Authors: Vieira Keline Targino , De Ataide Márcia Barroso Camilo , Xavier Antonia Tayana da Franca , Pereira Francisco Gilberto Fernandes
Published: October 2018

Resumo: Objetivou-se analisar a assistência à saúde na percepção de pessoas surdas com diabetes mellitus (DM). Trata-se de estudo descritivo comabordagem qualitativa. Participaram quatro pessoas com surdez e DM. A coleta das informações ocorreu mediante entrevista semi-estruturada.Constatou-se que existe barreira na interação entre surdos e profissionais da saúde, devido à falta de qualidade da comunicação, que inviabiliza umatendimento humanizado e de qualidade, tendo como consequência um manejo desajustado em DM.Descritores: Diabetes mellitus; Doença crônica; Surdez; Cuidado de Enfermagem.Deaf awareness of diabetes mellitus on assistance in healthAbstractAbstract: This study aimed to analyze health care in the perception of deaf people with diabetes mellitus (DM). This is a descriptive study with qualitativeapproach. Participated in four people with deafness and diabetes mellitus. Data collection occurred by means of a semi-structured interview.It was found that there is a barrier in the interaction between deaf and health professionals, due to lack of communication quality, which prevents ahumanized and quality, resulting in an inadequate management of DM.Descriptors: Diabetes mellitus; Chronic disease; Deafness; Nursing care.Atención a la salud: la percepción de las personas sordas con diabetes mellitusResumen: Este estudio tuvo como objetivo analizar la atención sanitaria en la percepción de las personas sordas con diabetes mellitus (DM). Este es unestudio descriptivo con enfoque cualitativo. Participó en cuatro personas con sordera y diabetes mellitus. Los datos fueron recolectados por entrevistasemi-estructurada. Se encontró que existe una barrera en la interacción entre los profesionales la salud y sordos, debido a la falta de calidad de lacomunicación, lo que impide una humanizado y calidad, lo que resulta en un manejo inadecuado de DM.Descriptores: Diabetes mellitus; Enfermedad crónica; Sordera; Atención de enfermería.
Orientações sobre aleitamento materno em consultas de pré-natal
Authors: Pereira Gardenia Gomes , Martins Mariana Cavalcante , Freire Oliveira Emilly Karoline , Da Silva Denise Maia Alves , Moura Ana Debora Assis
Published: October 2018

Resumo: Objetivou-se avaliar a atuação do enfermeiro na consulta de pré-natal quanto às orientações sobre aleitamento materno. Pesquisa observacional não participante, quantitativa, realizada em três Centros de Saúde da Família de Fortaleza-CE, Brasil, durante atendimento a 54 gestantes, utilizando um checklist. Das 54(100%) consultas observadas, verificou-se percentual reduzido em relação às orientações: anatomia da mama 1(1,9%), posição para amamentar 5(9,3%) e pega adequada 18(33,3%); em contrapartida o preparo da mama 35(64,8%) e duração do aleitamento 40(74,1%), foram mais orientados. Identificaram-se lacunas que devem ser minimizadas por meio da corresponsabilidade dos profissionais referente à prática do aleitamento materno. Descritores: Aleitamento materno; enfermagem; cuidado pré-natal.Guidelines on breastfeeding in prenatal consultationsAbstract: The objective was to assess the performance of nurses in prenatal consultation regarding the guidelines on breastfeeding. Quantitative observational non-participant research carried out in three Family Health Centers of Fortaleza-CE, Brazil, during the assistance to 54 pregnant women through a checklist. Of the 54 (100%) consultations observed, there was a low percentage on the following guidelines: breast anatomy 1 (1.9%), proper position 5 (9.3%) and proper grasp 18 (33.3%); however, breast preparation 35 (64.8%) and duration of breastfeeding 40 (74.1%) were more oriented. We identified gaps that should be minimized through the professionals’ corresponsibility on the promotion of breastfeeding.Descriptors: Breast Feeding, Nursing, Prenatal Care.Orientaciones acerca de la lactancia materna en las consultas de prenatalResumen: El objetivo fue evaluar la actuación del enfermero en la consulta de prenatal cuanto a las orientaciones sobre lactancia materna. Investigación observacional no participante, en tres Centros de Salud Familiar de Fortaleza-CE, Brasil, durante atención a 54 mujeres embarazadas, utilizándose lista de verificación. De las 54 (100%) consultas observadas, hubo bajo porcentaje en las siguientes orientaciones: anatomía de la mama 1(1,9%), posición para amamantar 5 (9, 3%) y pega 18 (33,3%); en contradicción, preparación de la mama 35 (64,8%) y duración de la lactancia 40 (74,1%), fueron más orientados. Se identificaron lagunas que deben ser minimizados a través de la responsabilidad de los profesionales en la promoción de la lactancia materna.Descriptores: Lactancia Maternal, Enfermería, Atención Prenatal.
CURRÍCULO INTEGRADO NO ENSINO SUPERIOR EM ENFERMAGEM: O QUE DIZEM OS ENFERMEIROS DOCENTES
Authors: Franco Elaine Cristina Dias , Soares Amanda Nathale , Bethony Maria Flávia Gazzinelli
Published: October 2018

Objetivo: estudo que buscou identificar como se configura o conceito de currículo integrado nos discursos de enfermeiros docentes de graduação em Enfermagem. Metodologia: estudo de caso em que foram realizadas entrevistas com sete docentes e os dados foram analisados pela técnica da análise de discurso. Resultados: o conceito de currículo integrado relacionou-se as diferenças entre os currículos tradicional e integrado, à organização em espiral dos conteúdos, à integração ensino-serviço e à sua relação com o trabalho no Sistema Único de Saúde. Conclusões: há uma contribuição para a ampliação das discussões sobre o currículo integrado e as suas potencialidades para a formação do enfermeiro.Descritores: Enfermagem, Ensino superior, Currículo.THE INTEGRATED CURRICULUM IN HIGHER EDUCATION IN NURSING: WHAT THEY SAY TEACHERS NURSESObjective: the study that aimed to identify the configuration of the concept of integrated curriculum in the speeches nurses of undergraduate nursing faculty. Methodology: case study whose interviews were conducted with seven teachers and the data were analyzed by the technique of discourse analysis. Results: the concept of integrated curriculum related to the differences between traditional and integrated curricula, the organization spiral of the contents, the teaching-service integration and its relation to the work in the National Health System. Conclusions: there is a contribution to the expansion of the discussions on the integrated curriculum and its potential for the formation of the nurse.Descriptors: Nursing, Higher education, Curriculum.EL PLAN DE ESTUDIOS INTEGRADO EN LA EDUCACIÓN SUPERIOR EN ENFERMERÍA: LO QUE DICEN LOS MAESTROS ENFERMERASObjetivo: estudio que trató de identificar la configuración del concepto de currículo integrado en los discursos de los profesores de enfermería. Metodologia: estudio de caso em que se entrevistó a siete maestros y los datos fueron analizados por la análisis del discurso. Resultados: el concepto de plan de estudios integrado en relación con las diferencias entre los planes de estudios tradicionales e integrada, la espiral organización de los contenidos, la integración docencia-servicio y su relación con el Sistema Nacional de Salud. Conclusións: hay una contribución a la expansión de las discusiones en el plan de estudios integrado y su potencial para la formación de los enfermeras.Descriptores: Enfermería, Enseñanza Superior, Plan de Estudios.
PAÍS ESTÁ PRONTO PARA UMA SOCIEDADE DE IDOSOS?
Authors: De Oliveira Maria Liz Cunha
Published: October 2018

Dois séculos atrás, passar dos 40 anos era algo incomum. Os que conseguiam eram considerados quase seres abençoados pelos deuses. Graças aos avanços médicos e sociais, a esperança de vida começou a aumentar num ritmo considerável no final do século XIX. Hoje, viver até 80 anos é habitual. E tudo indica que, dentro de pouco tempo, chegar aos 100 será bastante normal.
Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives
Authors: Sinha Rajeshwari , Shukla Pratyoosh
Published: October 2018

With the unprecedented rise of drug-resistant pathogens, particularly antibiotic-resistant
bacteria, and no new antibiotics in the pipeline over the last three decades, the issue of antimicrobial
resistance has emerged as a critical public health threat. Antimicrobial Peptides (AMP) have
garnered interest as a viable solution to this grave issue and are being explored for their potential
antimicrobial applications. Given their low bioavailability in nature, tailoring new AMPs or strategizing
approaches for increasing the yield of AMPs, therefore, becomes pertinent.

The present review focuses on biotechnological interventions directed towards enhanced AMP
synthesis and revisits existing genetic engineering and synthetic biology strategies for production of
AMPs. This review further underscores the importance and potential applications of advanced gene
editing technologies for the synthesis of novel AMPs in future.
Quercetin and its Natural Sources in Wound Healing Management
Authors: Polera Nicoletta , Badolato Mariateresa , Perri Filomena , Carullo Gabriele , Aiello Francesca
Published: October 2018

Giving a glance to the report of Wound Care Market by Product updated in 2017,
we can see that wound care market is expected to reach USD 22.01 billion by 2022 from USD
18.35 billion at a CAGR of 3.7%. Numerous factors are driving the growth of this market, including
the increasing prevalence of chronic wounds and acute wounds, increasing aged
population, rising R&D activities and advancement in the field of wound care research. Advanced
wound management products are accounted for the largest market share in 2017.
These evidences mean that the wound care research represents a Clinical Emergency other
than an interesting Marketing tool. Drug therapies so far fight efficaciously with the opportunistic
pathologies derived from chronic wounds, although an unsolved challenge is still finding
a useful remedy to correct the impaired wound healing process and overcome the chronic
wound state, to avoid bacterial rising and severe pain. Traditional medicinal plants have been
widely used in the management of wounds and different plant extracts have been evaluated
for their wound healing properties through both in vitro and in vivo studies. Their phytochemical
components in particular quercetin, contribute to their remedial properties in wound
repair. Quercetin has important biological activities related to the improvement of the wound
healing process. The present review discusses and focuses on the latest findings of the wound
healing properties of quercetin, alone or as a part of plant extract, and its role as a new frontier
in wound repair.
Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Evidence from a Real-World Perspective - Part 2
Authors: Kisialiou Aliaksei , Prinzi Giulia , Lamonaca Palma , Cardaci Vittorio , Tomino Carlo , Fini Massimo , Bonassi Stefano , Russo Patrizia
Published: October 2018

Background:

We report a comprehensive overview of current COPD therapies from a
real-world experience.

Objective:

Critically review the opportunities and the challenges occurring in the real-world treatment
of COPD.

Methods:

This is a review that also report results from COPD patients treated with standardized
therapy including pulmonary rehabilitation (Real World Data – RWD).

Conclusion:

Comprehensive assessment of COPD management requires strategies able to evaluate
efficacy and usefulness in a real-world population, that take into account the interaction between
experience and academic training, research, adherence to guidelines and judgments in order to plan
the appropriate and optimum use of available strategies.
Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility
Authors: Abbhi Vasudha , Piplani Poonam
Published: October 2018

Background:

Glaucoma is a progressive optic neuropathy causing visual impairment
and Retinal Ganglionic Cells (RGCs) death gradually posing a need for neuroprotective
strategies to minimize the loss of RGCs and visual field. It is recognized as a multifactorial
disease, Intraocular Pressure (IOP) being the foremost risk factor. ROCK inhibitors have been
probed for various possible indications, such as myocardial ischemia, hypertension, kidney
diseases. Their role in neuroprotection and neuronal regeneration has been suggested to be of
value in the treatment of neurological diseases, like spinal-cord injury, Alzheimer’s disease
and multiple sclerosis but recently Rho-associated Kinase inhibitors have been recognized as
potential antiglaucoma agents.

Evidence Synthesis:

Rho-Kinase is a serine/threonine kinase with a kinase domain which is
constitutively active and is involved in the regulation of smooth muscle contraction and stress
fibre formation. Two isoforms of Rho-Kinase, ROCK-I (ROCK β) and ROCK-II (ROCK α)
have been identified. ROCK II plays a pathophysiological role in glaucoma and hence the inhibitors
of ROCK may be beneficial to ameliorate the vision loss. These inhibitors decrease
the intraocular pressure in the glaucomatous eye by increasing the aqueous humour outflow
through the trabecular meshwork pathway. They also act as anti-scarring agents and hence
prevent post-operative scarring after the glaucoma filtration surgery. Their major role involves
axon regeneration by increasing the optic nerve blood flow which may be useful in
treating the damaged optic neurons. These drugs act directly on the neurons in the central visual
pathway, interrupting the RGC apoptosis and therefore serve as a novel pharmacological
approach for glaucoma neuroprotection.

Conclusion:

Based on the results of high-throughput screening, several Rho kinase inhibitors
have been designed and developed comprising of diverse scaffolds exhibiting Rho kinase inhibitory
activity from micromolar to subnanomolar ranges. This diversity in the scaffolds with
inhibitory potential against the kinase and their SAR development will be intricated in the
present review. Ripasudil is the only Rho kinase inhibitor marketed to date for the treatment
of glaucoma. Another ROCK inhibitor AR-13324 has recently passed the clinical trials
whereas AMA0076, K115, PG324, Y39983 and RKI-983 are still under trials. In view of this,
a detailed and updated account of ROCK II inhibitors as the next generation therapeutic
agents for glaucoma will be discussed in this review.
Outer Membrane Proteins of Salmonella as Potential Markers of Resistance to Serum, Antibiotics and Biocides
Authors: Futoma-Kołoch Bożena , Bugla-Płoskońska Gabriela , Dudek Bartłomiej , Dorotkiewicz-Jach Agata , Drulis-Kawa Zuzanna , Gamian Andrzej
Published: October 2018

Salmonellosis continues to be a significant worldwide health problem. Despite rapid progress in identifying mechanisms of Salmonella virulence and resistance to chemicals, our knowledge of these mechanisms remains limited. Furthermore, it appears that the resistance to antibiotics can be amplified by ubiquitous usage of the disinfectants (biocides), both by industry and by ordinary households. Salmonella, as other Gram-negative bacteria possess outer membrane proteins (OMPs), which participate in maintaining cell integrity, adapting to environment, and interacting with infected host. Moreover, the OMPs may also contribute to resistance to antibacterials. This review summarizes the role of OMPs in Salmonella serum resistance, antibiotics resistance and cross-resistance to biocides. Although collected data do not allow to assign OMPs as markers of the Salmonella susceptibility to the above-mentioned factors, some of these proteins retain a dominant presence in certain types of resistance.
Vascular Damage in Obesity and Diabetes: Highlighting Links Between Endothelial Dysfunction and Metabolic Disease in Zebrafish and Man
Authors: Wiggenhauser Lucas Moritz , Kroll Jens
Published: October 2018

Endothelial dysfunction is an initial pathophysiological mechanism of vascular damage and is further recognized as an independent predictor of negative prognosis in diabetes-induced micro- and macrovascular complications. Insight into the capability of zebrafish to model metabolic disease like obesity and type II diabetes has increased and new evidence on the induction of vascular pathologies in zebrafish through metabolic disease is available. Here, we raise the question, if zebrafish can be utilized to study the initial impairments of vascular complications in metabolic disorders. In this review, we focus on the advances made to develop models of obesity and type II diabetes in zebrafish, discuss the key points and characteristics of these models, while highlighting the available information linked to the development of endothelial dysfunction in zebrafish and man. We show that larval and adult zebrafish develop metabolic dysregulation in the settings of obesity and diabetes, exhibiting pathophysiological mechanisms, which mimic the human condition. The most important genes related to endothelial dysfunction are present in zebrafish and further display similar functions as in mammals. Several suggested contributors to endothelial dysfunction found in these models, namely hyperinsulinaemia, hyperglycaemia, hyperlipidaemia and hyperleptinaemia are highlighted and the available data from zebrafish are summarised. Many underlying processes of endothelial dysfunction in obesity and diabetes are fundamentally present in zebrafish and provide ground for the assumption, that zebrafish can develop endothelial dysfunction. Conservation of basic biological mechanisms is established for zebrafish, but focused investigation on the subject is now needed as validation and particularly more research is necessary to understand the differences between zebrafish and man. The available data demonstrate the relevance of zebrafish as a model for metabolic disease and their ability to become a proponent for the investigation of vascular damage in the settings of obesity and diabetes.
Nutraceuticals and Diet-based Phytochemicals in Type 2 Diabetes Mellitus: From Whole Food to Components with Defined Roles and Mechanisms
Authors: Onaolapo Adejoke Yetunde , Onaolapo Olakunle James
Published: October 2018

Background:

Over the past decades, the development and use of an array of prescription medications have considerably improved the clinical management of type 2 diabetes mellitus and the quality of life of patients. However, as our knowledge of the associated risk factors and approaches to its management increases, the increasing roles of diet and the composition of the diet in the etiology and successful management of diabetes mellitus are being illuminated. Presently, a lot of attention is being given to nutraceuticals and certain phytochemicals that are integral parts of the human diet. It is believed that a clearer understanding of their roles may be crucial to ‘non-invasive’ or minimallyintrusive management, with regards to daily living of patients. In this review, an overview of nutraceutical components and phytochemicals that may be of benefit, or had been known to be beneficial in diabetes mellitus is given. Also, how the roles of such dietary components are evolving in the management of this disorder is highlighted. Lastly, the obstacles that need to be overcome before nutraceuticals can be considered as options for the clinical management of diabetes mellitus areconsidered.

Conclusion:

Despite studies that demonstrate their efficacy, no nutraceutical or food-derived compound has been formally adopted as a direct replacement for any class of antidiabetic drugs.
3D-QSAR and Molecular Docking Studies on Design Anti-Prostate Cancer Curcumin Analogues
Authors: Meng Xi , Cui Lianhua , Song Fucheng , Luan Mingyuan , Ji Junjie , Si Hongzong , Duan Yunbo , Zhai Honglin
Published: October 2018

Background:

Prostate cancer is one of the most common tumors in the world and the fifth leading cause of male cancer death. Although the treatment of localized androgen-dependent prostate cancer has been successful, the efficacy of androgen-independent metastatic disease is limited. Curcumin, a natural product, has been found to inhibit the proliferation of prostate cancer cells.

Objective:

To design curcumin analogs with higher biological activity and lower toxicity and side effects for the treatment of prostate cancer.

Methods:

In this study, the three dimensional-quantitative structure activity relationship (3DQSAR) and molecular docking studies were performed on 34 curcumin analogs as anti-prostate cancer compounds. We introduced OSIRIS Property Explorer to predict drug-related properties of newly designed compounds.

Results:

The optimum CoMSIA model exhibited statistically significant results: the cross-validated correlation coefficient q2 is 0.540 and non-cross-validated R2 value is 0.984. The external predictive correlation coefficient Rext 2 is 0.792. The information of structure-activity relationship can be obtained from the CoMSIA contour maps. In addition, the molecular docking study of the compounds for 3ZK6 as the protein target revealed important interactions between active compounds and amino acids.

Conclusion:

Compound 28i may be a new type of anti-prostate cancer drug with higher biological activity and more promising development.
MALDI MS Analysis to Investigate the Lipid Composition of Sperm
Authors: Engel Kathrin M. , Jakop Ulrike , Müller Karin , Grunewald Sonja , Paasch Uwe , Schiller Jürgen
Published: October 2018

Background:

The sperm plasma membrane meets the requirements of sperm transit
through the female genital tract and subsequent fertilization. Commonly, the (phospho)lipid composition
of sperm is characterized by tremendous amounts of highly unsaturated fatty acyl residues such
as docosahexaenoic and docosapentaenoic acid. While human sperm contain almost exclusively diacyl
lipids, many animal sperm additionally contain significant amounts of ether lipids such as alkylacyl-
and alkenyl-acyl lipids (plasmalogens).

Hypothesis/Objective:

It is suggested that deviations from the typical lipid composition are indicative
of pathological changes. Therefore, simple methods to elucidate the sperm lipid composition are essential.

Method:

Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is a fast
and simple method. Since the selection of the most suitable matrix is a crucial step in MALDI MS,
this topic will be highlighted. It will also be shown that MALDI MS can be easily combined with
thin-layer chromatography to overcome ion suppression effects.

Results:

The lipid composition of sperm from different species can be elucidated by MALDI MS.
However, different matrix compounds have to be used to record positive and negative ion mass spectra.
Since some sperm (glyco)lipids are characterized by the presence of sulfate residues which suppress
the detection of less acidic lipids in the negative ion mode, previous separation is often necessary.
It will be also emphasized that plasmalogens can be easily identified by either enzymatic digestion
or treatment with acids.

Conclusion:

MALDI MS is a reliable method to obtain sperm lipid fingerprints in a simple and convenient
way.
An Overview of EEG Seizure Detection Units and Identifying their Complexity- A Review
Authors: Rajendran T. , Sridhar K.P.
Published: October 2018

Objective:

In everyday life, more and more people suffer from various diseases. To prefer
the best medicine for them, an exact diagnosis is to be done. For example, the Epilepsy patients
encounter many challenges because they must take precautionary measures to protect themselves
from injury during a sudden occurrence of seizures.

Materials and Methods:

The investigations of epilepsy can be made analysing Electroencephalogram
(EEG) motions to break down the conduct of the cerebrum amid seizures. To find the exact
seizure frame in EEG signal is difficult and the overall analysis results is tedious in terms of human
error.

Results:

Hence, there is a need for automatic detection, exact prediction, and classification of
EEG waves. Similarly, another potential utilization of EEG signal investigation is in the prediction
of epileptic seizures before they occur. This step relieves the patients of anxiety and empowers
their guardians.

Conclusion:

In this study, we first concentrated on seizure discovery and classification issue. Secondly,
some bits of knowledge on the complications involved in seizure-management are mentioned.
Finally, some suggestions are listed with seizure classifications.
How Does Plasma Activated Media Treatment Differ From Direct Cold Plasma Treatment?
Authors: Attri Pankaj , Park Ji Hoon , Ali Anser , Choi Eun Ha
Published: October 2018

Objective: The aim of the paper is to investigate the optimum condition for generation of Plasma
Activated Media (PAM), where it can deactivate the cancer cells while minimum damage for normal cells.

Background: Over past few years, cold atmospheric Plasma-Activated Media (PAM) have shown its promising
application in plasma medicine for treatment of cancer. PAM has a tremendous ability for selective anti-cancer
capacity in vitro and in vivo.

Methods:

We have analyzed the radicals in air using the optical emission spectroscopy and in culture media
using chemical analysis. Further, we have tested the toxicity of PAM using MTT assay.

Results:

We observed that more cancer cell death is for the Ar plasma followed by the Ar-N2 plasma, and the
least cell death was observed for the Ar-O2 plasma at all treatment times both by direct treatment and through
PAM treatment. The concentration of the RNS species is high for Ar-N2 plasma in gas as well as inside the
culture media compared to that for pure Ar plasma. However, the difference is significantly less between the Ar
plasma treatments and the Ar-N2 plasma treatments, showing that ROS is the main factor contributing to cell
death.

Conclusion:

Among all three feeding gas plasmas the best system is Ar-O2 plasma for direct treatments towards
the cancer cells. In addition, the best system for PAM preparation is Ar-N2 at low time treatments (1 min and 2
min) because it has no effect on normal cells, but kills the cancer cells.
A Simple and Robust Process for Large-Scale Synthesis of 4-Methylenepiperidine Hydrochloride
Authors: Chen Ao , Li Ziqian , Li Minghai , Liu Keke , Li Weimin , Tan Chen
Published: October 2018

4-Methylenepiperidine hydrochloride 1 is a key intermediate for synthesis of the novel antifungal
drug efinaconazole 2. In this work, a simple and robust process has been developed to synthesize
4-methylenepiperidine hydrochloride 1, with a high overall yield of 99.1% at a high purity of
99.7% in a large-scale. Moreover, this synthetic process avoided the uses of organolithium reagent and
column chromatography process which are not desirable for industrial production.