bluuebunny/crossref_metadata_2025 huggingface dataset:
DIÁLOGOS PERTINENTES ACERCA DA UTILIZAÇÃO DE RECURSOS EDUCACIONAIS ABERTOS PARA A EDUCAÇÃO
Authors: Pinto Anamelea De Campos , Silva Júlio César Correia da , Mercado Luis Paulo
Published: January 2019

A crescente profusão e difusão das tecnologias digitais de informação e comunicação (TDIC) possibilitaram a criação de novas práticas de ensino que incorporam a utilização de recursos multimidiáticos como facilitadores do processo de ensino e aprendizagem dos sujeitos conectados. Nesse sentido, os Recursos Educacionais Abertos (REA) surgem como uma proposta inovadora para o campo da educação e tem como objetivo constituir autores digitais mais responsáveis na edificação e partilha do conhecimento, possibilitando a engendração do conceito de abertura e liberdade face as especificidades do licenciamento em Creative Commons (CC) e as etapas de produção e execução dos REA. Para nortear a construção do artigo, que se caracteriza como uma pesquisa teórica acerca do usabilidade de REA, buscou-se em Silva et al (2017), Amiel (2012), Pesce (2013), Santana et al (2012) e Litto e Mattar (2017)  respostas para solucionar tais problemáticas: Quais elementos são essenciais para a construção e usabilidade dos REA? De que forma podemos propor a usabilidade desses recursos para a educação? Desse modo descobriu-se que o alicerce deste artigo está na forma de investigar e consultar a importância do uso dos REA como uma política pública educacional, sobretudo na proposta epistemológica da Teoria Conectivista e nas contribuições históricas da Educação Aberta pela qual a (co)produção e a (co)aprendizagem dos REA se apoia. Como resultado, apresentamos a proposição de alguns elementos norteadores da construção, execução e utilização dos REA, promovendo diálogos pertinentes para a preparação de um guia de recomendações de usabilidade, abordando conteúdos introdutórios acerca da temática em tela e propondo como um dos elementos a formatação de uma plataforma online híbrida, que denominamos de restart, para organizar e contabilizar obras em REA ou transformadas em Domínio Público, complementando as cinco liberdades essenciais para a condução dos REA, que são: revisar, reutilizar, remixar e redistribuir. A finalidade desse estudo é discutir as formas de licenciamento em CC, o acesso aos recursos, um método de trabalho que leve em consideração a saúde, bem-estar e segurança dos usuários e produtores de REA e assegurar uma avaliação aberta na concepção dos REA, trazendo tais peculiaridades como componentes do guia, que estejam em conformidade com as suas bases legais-normatizadoras.
ASTROLUDENS: PRODUÇÃO DE CONHECIMENTO INFANTIL
Authors: D' Ávila Carina Nascimento , D' Ávila Victor , Spinelli Patricia
Published: January 2019

Registro fotográfico que compõe o projeto Astroludens. Inspirado na reconhecida tese “Homo Ludens” de Johan Huizinga (1983), a qual defende que todo ser humano é sobretudo lúdico, esse projeto tem o compromisso de dialogar com a produção de conhecimento de crianças de 0 a 6 anos que transitam pelo Museu de Astronomia e Ciências Afins (MAST), um público cada vez mais presente e cativo. Para isso, é necessária a criação de novas metodologias científicas que entrelaçam produção teórica e prática, propondo inovações materiais e intelectuais. O projeto acontece criando liames de interrelação não só de conceitos da cultura infantil e museal, mas da própria cultura digital. Neste pequeno e pretenciosamente provocador ensaio de uma única fotografia e pouco texto, intenciona-se tensionar algumas certezas já endurecidas até os dias de hoje. E enaltecer a evidente produção de conhecimento infantil.
JUSTIÇA RESTAURATIVA E MEDIAÇÃO PENAL EM PORTUGAL CONTEXTUALIZAÇÃO E REFLEXÕES SOBRE A LEI N.º 21/2007
Authors: Wildner Zambiasi Vinícius , Cavol Klee Paloma Marita
Published: January 2019

A Justiça Restaurativa surge como novo paradigma de resolução de conflitos, em substituição ou de modo complementar ao tradicional sistema punitivista, a fim de apresentar uma resposta menos danosa e mais humanitária e reparadora. Neste contexto surge a Lei n.º 21/2007, responsável por regular a mediação penal de adultos em Portugal. Entretanto, embora a lei represente um importante marco na política criminal do país, possui graves falhas na sua redação que diminuem excessivamente a sua aplicabilidade.
A AUDIÊNCIA DE CONCILIAÇÃO E MEDIAÇÃO NO SISTEMA PROCESSUAL CIVIL
Authors: Pinheiro Guilherme César
Published: January 2019

Este artigo objetiva discutir alguns aspectos relativos à audiência de conciliação e mediação no processo civil brasileiro, em razão do crescente estímulo à solução consensual de conflitos, verificado pelo movimento de reformas processuais pós-1988. Tomando-se como marco o processualismo constitucional democrático, necessário se faz enfatizar as premissas básicas para se compreender adequadamente o uso da mediação e da conciliação como técnica de solução consensual de conflitos, para evitar que o furor neoliberal de alta produtividade desvirtue o seu propósito constitucional. Também é importante ressaltar as particularidades procedimentais da audiência de conciliação e mediação nos procedimentos comum e especiais, devido ao fato de o sistema processual brasileiro possuir muitas variações.
A PRESCRIÇÃO DAS EXECUÇÕES FISCAIS E O MODELO COOPERATIVO PROCESSUAL / THE TAX EXECUTIONS’ PRESCRIPTION AND THE PROCEDURAL COOPERATIVE MODEL
Authors: De Souza Netto José Laurindo , Guilherme Gustavo Calixto
Published: January 2019

O presente artigo objetiva contextualizar o modelo cooperativo do Código de Processo Civil nas execuções fiscais para o reconhecimento da prescrição tributária. Trata-se de uma análise doutrinária e jurisprudencial que apresenta a nova perspectiva do Código, as características da prescrição tributária e os julgados recentes dos Tribunais. O artigo conclui que, para que a prescrição seja reconhecida em execuções fiscais, deverá ser ponderado o princípio da cooperação.
REFLEXÕES SOBRE A APLICAÇÃO DA TEORIA DOS PRECEDENTES NO DIREITO TRIBUTÁRIO BRASILEIRO / COMMENTS ON THE APPLICATION OF MANDATORY PRECEDENTS IN BRAZILIAN TAX LAW
Authors: Iglesias Tadeu Puretz
Published: January 2019

O presente estudo tem por objeto analisar a aplicação dos precedentes obrigatórios no direito brasileiro, especialmente em matéria tributária, investigando se a introdução da denominada teoria dos precedentes vinculantes vem sendo aplicado de forma adequada em nosso ordenamento jurídico.
Concepções de Docentes sobre o uso de Metodologias Ativas da Aprendizagem: Um Enfoque na Formação de Enfermeiros
Authors: Oliveira Gésica Kelly Da Silva , Rodrigues Kátia Calligaris , Freitas Maria Aparecida De Oliveira
Published: January 2019

As vertiginosas mudanças na conjuntura social têm posto em reflexão, de maneira contundente, os aspectos relacionados a formação profissional em enfermagem. Assim, esta discussão surge mediante a necessidade de considerar os fatores que são próprios do trabalho em saúde, tais como a relação intrínseca entre as atividades práticas e a teoria, o cuidado holístico, crítico e humanizado, visto que estes elementos são essenciais para o apropriado exercício profissional. Este trabalho objetivou investigar a percepção dos docentes do curso de graduação em enfermagem sobre a utilização e contribuição das metodologias ativas da aprendizagem no processo de formação e desenvolvimento do profissional enfermeiro. Trata-se de um estudo de natureza qualitativa de caráter exploratório-descritivo, que foi realizado com docentes de um Centro Universitário do Agreste Pernambucano. Os dados foram coletados por meio de entrevista semiestruturada, para apreciação dos dados obtidos foirealizada análise de conteúdo, seguindo o referencial teórico proposto por  Minayo. Os resultados demonstraram que os docentes compreendem a relevância das metodologias ativas para a formação em enfermagem, entretanto evidenciamos não haver um planejamento de um ensino ativo, pelo professor, demonstrando afinidade com a transmissão de conteúdos, o que sinaliza a importância da atitude reflexiva constante no campo da docência em enfermagem.
Parent-child learning conversations in action
Authors: Aubrey-Smith Fiona
Published: January 2019

Some schools are reducing teacher workload and boosting parental engagement by scrapping homework and moving to a system of ‘Learning Conversations’. Fiona Aubrey-Smith explains
Inclusion – the secret to success at Thames View
Authors: O'Connell Suzanne
Published: January 2019

Thames View Infants Academy is in the top three per cent of schools for attainment but is located in the most deprived ward of the sixth most deprived authority in the country. Suzanne O'Connell finds out how inclusion is at the heart of what they do and the secrets to their success
Attachment-aware schools
Authors: Martindale Darren
Published: January 2019

Attachment-aware and trauma-informed practice can help to support some of the most vulnerable pupils in our schools, including those who are looked after. Virtual school head Darren Martindale advises
Innovative school projects
Authors: Lee-Potter Emma
Published: January 2019

As far as innovative facilities projects go, Aldingbourne Primary School perhaps takes the gold medal – from a diner made from shipping containers to a double decker bus-based breakfast club. Emma Lee-Potter takes a look
Reflections on recruitment
Authors: Jones Rachel
Published: January 2019

Getting it right is absolutely imperative. Get it wrong and that has a tremendous impact on productivity, morale, workload and outcomes for children. Rachel Jones offers her reflections on the recruitment challenge
Important implementation constructs for federal agencies in health and human service settings that are selecting, monitoring, and supporting grantees
Authors: Dymnicki Allison , Bzura Robin , Osher David , Wandersman Abraham , Duplantier Dan , Boyd Michelle , Cash Amanda , Hutchison Lindsey
Published: January 2019

Background:

Federal agencies and other funders seeking to maximise their impact aim to understand factors associated with implementing evidence-based interventions (EBIs) to address health problems. Challenges exist, however, in synthesising information from different disciplines and reaching agreement about these factors due to different terminology, frameworks, and measures being used in different fields.

Methods:

A mixed-methods approach was used to identifying a set of implementation constructs helpful for selecting, monitoring, and supporting federal grantees in health and human service settings. Three phases of research were conducted: a literature review, structured expert interviews, and consensus building. Interviews with implementation experts were used to validate a set of implementation constructs identified in the literature review as strongly and consistently related to successful implementation of EBIs in international contexts. A modified Delphi approach was used with a technical working group (TWG) of federal staff to agree on the constructs most relevant for federally funded EBIs.

Findings:

This process yielded 11 constructs related to either the intervention, the intersection between the invention and context, or the implementation process. These constructs are areas of interest when integrating research evidence into routine practice. Expert interviewees recommended establishing clear, consistent construct definitions before developing valid, feasible measures of the constructs. In contrast to the numerous and specific constructs advanced by researchers, federal TWG members favoured fewer constructs with more generalisability.

Discussion and conclusions:

This article demonstrates the translation work required for policy contexts and highlights a successful approach to translate evidence from implementation science research for federal staff.
Cell-Free SHOX2 DNA Methylation in Blood as a Molecular Staging Parameter for Risk Stratification in Renal Cell Carcinoma Patients: A Prospective Observational Cohort Study
Authors: Jung Maria , Ellinger Jörg , Gevensleben Heidrun , Syring Isabella , Lüders Christine , de Vos Luka , Pützer Svenja , Bootz Friedrich , Landsberg Jennifer , Kristiansen Glen , Dietrich Dimo
Published: January 2019

BACKGROUND

Novel targeted treatments and immunotherapies have substantially changed therapeutic options for advanced and metastatic renal cell carcinomas (RCCs). However, accurate diagnostic tests for the identification of high-risk patients are urgently needed. Here, we analyzed SHOX2 mRNA expression in RCC tissues and SHOX2 gene body methylation quantitatively in circulating cell-free DNA (ccfDNA) and RCC tissues with regard to risk stratification.

METHODS

The clinical performance of SHOX2 methylation was tested retrospectively and prospectively in a training and testing cohort of RCC tissue samples (n = 760 in total). SHOX2 mRNA expression analysis was included in the training cohort. In matched blood plasma samples from the testing cohort (n = 100), we prospectively examined the capability of pretherapeutic quantitative SHOX2 ccfDNA methylation to assess disease stage and identify patients at high risk of death.

RESULTS

SHOX2 gene body methylation was positively correlated with mRNA expression in RCC tissues (training cohort: Spearman ρ = 0.23, P < 0.001). SHOX2 methylation in tissue and plasma strongly correlated with an advanced disease stage (training cohort: ρ = 0.28, P < 0.001; testing cohort/tissue: ρ = 0.40, P < 0.001; testing cohort/plasma: ρ = 0.34, P = 0.001) and risk of death after initial partial or radical nephrectomy [training cohort: hazard ratio (HR) = 1.40 (95% CI, 1.24–1.57), P < 0.001; testing cohort/tissue: HR = 1.16 (95% CI, 1.07–1.27), P = 0.001; testing cohort/plasma: HR = 1.50 (95% CI, 1.29–1.74), P < 0.001].

CONCLUSIONS

Pretherapeutic SHOX2 ccfDNA methylation testing allows for the identification of RCC patients at high risk of death after nephrectomy. These patients might benefit from an adjuvant treatment or early initiation of a palliative treatment.
Mutatis mutandis: os dramas da forma. Nos dois mil anos da morte de Ovídio, criador das Metamorfoses
Authors: Miranda Margarida
Published: January 2019

Ao contrário da sorte de muitas outras obras dos autores greco­‑romanos, as Metamorfoses de Ovídio estiveram sempre presentes na tradição literária europeia. O poema inspirou e continua a inspirar intelectuais e artistas de todos os tempos, incluindo poetas, pintores, escultores, músicos e coreógrafos. Nos últimos anos assistimos ao crescimento do interesse por Ovídio, não apenas enquanto poeta espirituoso dos salões e do amor requintado, mas também enquanto poeta da erudição mitológica aliada à complexidade da natureza humana, sujeita à dor e à morte. Mas a verdade é que a inspiração em Ovídio não atraiu apenas os homens de letras. O tesouro artístico da Europa tem nas Metamorfoses uma das maiores fontes de inspiração. Nenhuma outra obra exerceu tão grande influência sobre a cultura europeia, a literatura e as artes. A influência das Metamorfoses nas artes e na cultura ocidental foi incomensurável, fazendo dela a maior fonte primária dos artistas europeus. Por isso o Festival das Artes teve por bem revisitá­‑la, criando a ocasião para a Exposição que se descreve nestas páginas.
PENGUJIAN STABILITAS SEDIAAN LUKA BAKAR BERBAHAN BAKU AKTIF KITOSAN/EKSTRAK PEGAGAN(CENTELLA ASIATICA)
Authors: Rismana Eriawan , Rosidah Idah , Bunga Olivia , Yunianto Prasetyawan , Erna Erna
Published: January 2019

The evaluation of wound-healing formula stability with active substance chitosan/Centella asiatica extract has been examined. The stability test was evaluated including physical, chemical and microbiology properties. The stability of physical property was observed by organoleptic parameters such as shape of gel, color, odor, homogeneity and weight of samples, while the stability of chemical property was studied by determination of pH and HPLC chromatogram profile. Meanwhile the stability of microbiology property was determined by contents by microbe and fungi contaminant. The results of evaluation showed that the wound-healing formula had a good stability for all properties after storage at room temperature for 24 weeks and 40 oC/75 % RH for 12 weeks.Keywords: Wound-healing formula, chitosan, Centella asiatica extract, evaluation, stability
Ornithological observations from Maratua and Bawean Islands, Indonesia
Authors: Burner Ryan C. , Shakya Subir B. , Haryoko Tri , Irham Mohammad , Prawiradilaga Dewi M. , Sheldon Frederick H
Published: January 2019

Indonesia’s many islands, large and small, make it an important center of avian diversity and endemism. Current biogeographic understanding, however, is limited by the lack of modern genetic samples for comparative analyses from most of these islands, and conservation efforts are hampered by the paucity of recent information from small islands peripheral to major, more commonly visited  islands. In November and December 2016, we visited Maratua, an oceanic coral atoll 50 km east of Borneo, and Bawean, a volcanic island on the Sunda continental shelf 150 km north of Java, to survey birds and collect specimens for morphological and genetic analysis. We detected many of the birds on Maratua’s historical lists and added several new resident and migratory species. Notably, we did not detect the Maratua White-rumped Shama (Copsychus malabaricus barbouri). On Bawean, we found the forests to be nearly silent and detected remarkably few resident land-bird species overall. The           severe population reduction of C. m. barbouri on Maratua and the drastic reduction of forest birds on Bawean probably result from overexploitation by the cage-bird trade in the first case and a combination of the cage-bird trade and pellet-gun hunting in the second.
A new species of Microhyla (Anura: Microhylidae) from Sumatra, Indonesia
Authors: Atmaja Vestidhia Yunisya , Hamidy Amir , Arisuryanti Tuty , Matsui Masafumi , Smith Eric N.
Published: January 2019

A new species of frog in the genus Microhyla is described from Sumatra, Indonesia based on molecular and morphological characters. This new species was previously confused with M. achatina, a Javan endemic. This new species is diagnosable from its congeners by possessing a medium size (SVL in adult males 18.20–21.32 mm, in adult females 20.37–25.51 mm), a stout body, a nostril–eyelid length being about half of the snout length, having a single outer palmar tubercle, a tibiotarsal articulation reaching the center of the eye (when the hindlimbs are stretched and adpressed to the body), having finger and toe tips dilated, having the dorsum with medial longitudinal grooves, and excibiting a very thin and short dark stripe on the temporal region above a wider cream stripe, extending from the postorbital area to insertion of forelimb. Additionally, the new species is characterized by possessing relatively little foot webbing. Uncorrected 16S rRNA sequence divergences between the new taxon and sequences for other congeneric species available ranged from 4.8 to 15.0%.
Aplicação de Ferramentas de Apoio Gerencial Contábil em uma Microempresa de Confecções
Authors: Honorio Filippi Mickael Martini , Bonemberger Simone Zuconelli
Published: January 2019

O objetivo deste estudo foi identificar como as ferramentas gerenciais selecionadas podem auxiliar na gestão empresarial de uma microempresa. O caso estudado foi um comércio de confecções, localizado na região Oeste do Paraná. O trabalho foi realizado no período de maio a dezembro de 2017 e compreendeu atividades direcionadas à gestão da empresa, especificamente a aplicação e análise das seguintes ferramentas: a) Modelo Canvas de Negócios, que serviu como um diagnóstico das necessidades principais da microempresa para os pesquisadores e como uma reflexão e direcionamento sobre o negócio para os empresários; b) Formação de Preço de Venda, que demonstrou a aplicabilidade de um método prático e eficiente na identificação de produtos que podem ter seus preços ajustados, bem como os produtos com maior rentabilidade e os que devem deixar de ser ofertados; e c) o Fluxo de Caixa Projetado, que permitiu aos gestores terem uma visão de suas contas a pagar e a receber em um período maior de tempo, e planejar ações para reduzir ou evitar o endividamento. Quanto a tipologia do estudo, esta pesquisa foi classificada como exploratória quanto aos objetivos, estudo de caso quanto aos procedimentos e qualitativa quanto à abordagem do problema, utilizando a triangulação de dados para a análise do caso, cruzando dados da teoria e conceitos das ferramentas gerenciais, documentos e relatórios da empresa e observação direta com entrevistas informais. O estudo prático apontou que as ferramentas gerenciais aplicadas auxiliam na geração de informações úteis para o planejamento e a tomada de decisão dos gestores e que a forma de gestão atual necessita de mudanças, pois o acompanhamento do negócio é premissa para o alcance do sucesso e do lucro.
A Simple Method to Measure Serum Lactate Concentration as A Reliable Parameter to Detect Flaps Blood-flow Patency
Authors: Handayani Siti
Published: January 2019

Background: The change in !ap blood flow patency can be monitored by measures. Subjective clinical observation through flap examinations is greatly biased depending on examiner’s experience. Standardised equipments of assessment are more reliable. This study propose the use of a device to provide an objective, safe,reproducible, simple, portable, and cost-effective method of monitoring flaps vitality by measuring serum concentration of lactic acid. Methods: An experimental lab-based study was conducted utilising Sprague-Dawley rats. Twenty rats were randomly assigned into two groups. In all subjects, bilateral groin-flaps were elevated. In rats of Group A, the vein pedicle of one-side of the flap was occluded while in Group B both the artery and vein on one-side of the flap were occluded. The other side of flaps in each rat were left unoccluded to serve as controls. Baseline serum lactate was measured in all flaps, then remeasured 60 and 120 minutes in all flaps after pedicle manipulations. Results: The mean lactate concentration of Group A rats with vein-occluded !aps was 2.5 ± 0.17 mmol/L at 0-min initially, and increased to 7.9 ± 0.16 mmol/L 120-min after occlusion (p<0.0005). The mean lactate concentration of Group B rats with arterial and venous flap occlusion was 2.55 ± 0.21 at baseline, which increased four-fold at 120-min to 9.86 ± 0.28 mmol/L (p<0.0005). Among the two groups, the lactate difference was also found to be significant. Conclusion: This study demonstrates that the proposed method detects serum lactate changes in flaps with vein and arteriovenous occlusions. This thus can be used as an objective parameter to evaluate compromised blood flow on cutaneous flaps.
Clinical and immunological efficiency of ultrasound treatment in combination with autoserotherapy in children with athensive bronchial asthma
Authors: Asiryan E. , Novikov P.
Published: January 2019

The aim of the study is to assess the clinical and immunological efficacy of ultrasound application on the spleen region in combination with autoserotherapy in children with atopic bronchial asthma. Materials and methods. We have examined 64 children with atopic bronchial asthma aged 6 to 18 years. Group A (32 children) received ultra-sound on the spleen region in combination with autoserotherapy simultaneously with basic treatment. Group B (32 children) received only basic therapy. The frequency of bronchial obstruction, the frequency of use of short-acting β2-agonists, the level of CD3+, CD4+, CD4+CD25+, CD19+, CD19+CD23++ lymphocytes, FcεRI+, CD23+IgE+-eosinophils were studied. Results. In the group of children who received ultrasound with autoserotherapy at the same time as basic treatment, the frequency of bronchial obstruction, as well as the number of doses of short-acting β2-agonists at 1 and 3 months statistically significantly lower than in the group of children receiving only basic therapy (p<0,05). In group A, a significant decrease in the relative and absolute levels of CD4+CD25+ T-lymphocytes (р<0,05) was noted. After 12–15 days, an increase in the relative and absolute levels of CD19+CD23++ - B-lymphocytes (p<0,05) was revealed. After 82–90 days, the absolute level of CD19+CD23++ B-lymphocytes is lower in group A than in group B (p<0,05). The relative and absolute level of eosinophils in group A is statistically significantly lower after 12–15 days, compared with group B (p<0,05). The level of FcεRI+ eosinophils in group A decreased after treatment to day 82–90 (p<0,05). Differences in the dynamics of the absolute level of CD23+IgE+ eosinophils in group A were established 12–15 and 82–90 days after the start of therapy (p<0,05). Significant differences between the groups were revealed when determining the absolute level of this indicator in 12–15 days from the start of the study (p<0,05). In group A, a decrease in IgE antibodies to D. pteronyssinus, cat and dog wool (p<0,05) was established. Conclusions. The use of ultrasound in combination with autoserotherapy in children with atopic bronchial asthma reduces the number of episodes of bronchial obstruction, reduces the use of short-acting β2-agonists, and reduces proallergic parameters.
The Stevens-Johnson syndrome and toxic epidermal necrolysis in patients of Vitebsk regional clinical hospital: a retrospective analysis
Authors: Vykhrystsenko I. , Velichansky O. , Sidorenko E. , Zakharova O.
Published: January 2019

The purpose of our research was to study the incidence and etiology of Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) according to the Vitebsk regional clinical hospital for the last 5 years. Materials and methods. The incidence of SJS/TEN in the last 5 years were studied and analyzed according to statistical reports of the allergic Department of the Vitebsk regional clinical hospital, and according to discharge summaries of patients treated with SJS/TEN. Results. Over the past 5 years, from 2012 to 2017, we observed 17 cases of SJS and 3 cases of TEN in patients aged 23 to 80 years (mean age 51,5 years), men – 14 (70%), women – 6(30%). SJS was found in men (65%), women (35%). All cases of TEN were identified only in men. In patients with SJS 6 cases (35%) are associated with treatment with carbamazepine, 2(12%) – korvalole, 2 – remantadine, 2 – nonsteroidal antiinflammatory drugs, 2 – antibiotics, 1 (6%) – fluconazole, 1 – angrymaks, and in 1 case the cause of the disease could not be established. In five out of twenty patients the occurrence of SJS/TEN was preceded by acute respiratory disease (25%). Treatment included local antiseptics, administration of saline solutions, systemic steroids, in 10% cases - intravenous immunoglobulin and plasmapheresis. One case of TEN was complicated by the syndrome of systemic inflammatory response, there were no fatalities. Conclusion. SJS/TEN is more common in men (70%) than in women (30%). The most common reason (35%) of the SJS/TEN is receiving treatment with carbamazepine. Early therapy with systemic steroids, intravenous immunoglobulin, plasmapheresis promotes the fastest recovery of patients.
Difficulties of differential diagnosis of blistering dermatoses. Pemphigus erythematosus: a case from clinical practice
Authors: Petrovа S. , Berzhets V. , Radikova O.
Published: January 2019

Differential diagnosis of blistering dermatoses is a problematic issue. Treatment and prognosis depend on the diagnosis. Differential diagnosis of the clinical and histologic picture of pemphigus erythematous is analyzed in the article. Necessary immunological methods are recommended for the diagnosis of the disease. The possibility of their use during the remission of the pathological process is considered.
Influence of chronic stress on secretory immunity
Authors: Lesnichenko D.
Published: January 2019

The study describes the effect of presence of chronic stress caused by living in the combat zone, the concentration of secretory IgA in serum and oral fluid of 23 healthy blood donors living in Donetsk during the period of military conflict. It was found that long-term residents in the conflict zone are characterized by a significant decrease in the concentration of secretory IgA in serum and in oral fluid. At the same time, among the aforementioned group of people there is an increase in the frequency of registration of test subjects with the content of the marker <3 mg/l in serum and <200 mg/l in oral fluid, which is not typical for the persons surveyed during the period of peace. A significant correlation of sIgA with the concentration of the marker in oral fluid in both groups is noted.
Russian sociological and psychological research of the family: meta-analisys
Authors: Solodnikov Vladimir V.
Published: January 2019

The article provides an analysis of specific features of the publications devoted to family in Russian sociological and psychological journals.  The author analyzes the materials from four scientific publications during the 2000-2016 period from the related field. The data of the review partially check with the results of the analysis of the articles published form 1986 to 1991, which allows the author to evaluate certain changes. Based on qualitative and quantitative analysis of certain markers, the author draws conclusions concerning the specifics of scientific paradigms and the state of normal science (according to T.Kuhn) applied to Russian sociology and psychology of family. The number of publications in the Russian psychological journals shows that family is a low-priority topic which is only viewed as a “context” for studying personalities (mainly child’s personality) or interpersonal relationships. The concept’s heterogeneity translates into a pronounced interest of psychologists towards methodological framework and a wide variety of tools to collect empirical evidence and is accompanied by the fragmentation of the professional community on the “school-journal” principle. The significance of family studies in the Russian sociology varies greatly but its paradigm is dual (with the natural sciences being dominant), more consistent and stable; it is more open for cross-disciplinary research and more oriented towards studying the family structure and interaction between family and other social institutions. From this perspective, it is personality (of spouses and children) that becomes the “context”, and the “school-journal” fragmentation characteristic of the Russian sociologists manifests itself in relation to foreign rather than domestic researchers. This requires from the family researchers more inter-disciplinary efforts and cooperation.
Malaria, hepatitis B and HIV /AIDS, and their co-infection among Patients Visiting Health Centres in Akure, Nigeria
Authors: Afolabi Olajide Joseph , Aremo A , H Oluwabunmi , Itansanmi I , I Anuoluwa
Published: January 2019

Co-infection is the simultaneous infection of host by multiple pathogenic species, which may co-exist together or not. In this study, the co-infection of malaria, HIV/AIDS and hepatitis B was investigated, using four different locations in Akure, Ondo State. Blood samples were aseptically collected from the left thumbs of 500 respondents using sterile lancets. Thin and thick smear of the blood samples were observed for malaria parasites using X100 magnification of the light microscope. Hepatitis B and HIV/AIDS were tested using diagnostic test kits. The results show that highest prevalence of malaria was observed in Oba-Ile (82.09%) among age group 31-40 years (92.72%).  The lowest prevalence was found in Ala-Ajagbusi (73.17%) among age group 21-30 years (70.03%). Highest prevalence of hepatitis (7.06%) was observed in Orita-Obele while the lowest prevalence was observed in Ala- Ajagbusi (4.88%).  HIV/AIDS infection was found Orita-Obele (1.76%, n=3) and Ala-Ajagbusi (2.44%, n=2). The results further show that all the individuals that tested positive to hepatitis B virus and HIV also tested positive to malaria. Also, 3 of the 5 individuals infected with HIV/AIDS tested positive to hepatitis B virus.  Similarly, malaria, hepatitis B virus and HIV cohabit in 2 individuals; 1 in age group 21-30 years and 1 in age group 31-40 years. Coinfection of malaria with hepatitis and HIV/AIDS suggests that malaria is an opportunistic infection among the hepatitis and AIDS patients. This calls for prompt malaria treatment among the immunocompromised patients. More so, there should be adequate and consistent public health advocacy programs, to enlighten the populace about malaria, hepatitis B and HIV/AIDS in order to completely mitigate the disease spread in the area.
Factors Affecting Parents' Acceptance towards Children with Familial Intellectual Disability (ID)
Authors: Gusrianti Elsa , Winarni Tri Indah , Faradz Sultana MH
Published: January 2019

Background: Familial intellectual disability (ID) is a condition where two or more family members are affected ID, which may influence the whole family well-being. Children with intellectual disability often receive negative response from the society, which may trigger different reactions from the parents, such as denial or neglect of their child. Besides, most parents give more attention and provide the best care for their children. Factors that may influence parents’ acceptance towards children with familial ID are social support, religious coping, supporting facilities, family income, education, mothers’s age, and other significant factors.Objective: This study was aimed to analyze factors that affect parents’ acceptance towards children with familial intellectual disabilities (ID).Methods: This was an analytic observational study with cross sectional approach. Data were collected using interview with 20 mothers of familial intellectually disabled children including demographic data, pedigree construction, using Parental Rejection Questionnaire (PARQ), Brief Arab Religious Coping Scale (BARCS), Social Support Questionnaire Short Form (SSQSR) and Supporting Facilities Questionnaires. Data was analyzed using multivariate logistic regression.Results: Parents’ acceptance was significantly affect by social support (p<0.05), while religious coping, supporting facilities, family income, education, and mothers’s age did not significantly influence parents’ acceptance (p >0.05).Conclusion: Social support has influenced parent’s acceptance of their familial ID Children
Hubungan usia ibu menikah dini dengan status gizi Balita di Kabupaten Temanggung
Authors: Khusna Nur Atmilati , Nuryanto Nuryanto
Published: January 2019

Latar Belakang : Pernikahan dini (menikah >18 tahun) dapat berpengaruh pada status gizi anak yang dilahirkan. Ibu yang menikah pada usia dini, berisiko memiliki anak berstatus gizi pendek, gizi kurus dan gizi buruk.Tujuan : Penelitian ini bertujuan untuk mengetahui hubungan antara usia ibu menikah dini dengan status gizi batita di Kabupaten Temanggung.Metode :  Penelitian ini termasuk penelitian observasi dengan desain cross-sectional pada 72 anak yang berusia 0-2 tahun dari ibu yang menikah dini dan dipilih secara consecutive sampling. Ibu dikatakan menikah dini jika usia ibu saat menikah <18 tahun. Status gizi batita diperoleh dari z-score PB/U dan  BB/U menggunakan baku antropometri WHO 2005. Analisis data menggunakan uji Chi-Square.Hasil : Hasil penelitian ini menunjukkan bahwa rerata usia ibu saat menikah dini adalah 15,9±0,98 tahun, sedangkan rerata usia batitanya saat ini 10,4±7,16 bulan. Persentase anak pendek pada kelompok usia ibu yang menikah dini saat berusia 14-15 tahun sebesar 43,5% dan pada kelompok yang menikah saat usia 16-17 tahun sebesar 22,4%. Persentase anak gizi kurang pada kelompok usia ibu yang menikah dini saat berusia 14-15 tahun adalah 17,4%, sedangkan pada  kelompok yang menikah saat usia 16-17 tahun sebesar 14,3%. Hal tersebut menunjukkan adanya kecenderungan semakin dini usia nikah ibu, semakin meningkat persentase anak pendek, tetapi secara statistik tidak berhubungan (p=0,067). Begitupula dengan gizi kurang yang juga terdapat kecenderungan semakin dini usia nikah ibu, semakin meningkat persentase gizi kurang, dan secara statistik juga tidak berhubungan (p=0,736).Kesimpulan : Terdapat kecenderungan semakin dini usia ibu menikah, semakin meningkat persentase anak pendek dan gizi kurang, tetapi secara statistik tidak ada hubungan antara usia ibu menikah dini dengan status gizi batita di Kabupaten Temanggung.
Perbedaan aktivitas fisik, screen time, dan persepsi ibu terhadap kegemukan antara balita gemuk dan non-gemuk di Kota Semarang
Authors: Syahidah Zulfah Asy , Wijayanti Hartanti Sandi
Published: January 2019

Latar Belakang: Kegemukan merupakan masalah gizi balita yang terus meningkat. Kurangnya aktivitas fisik dan lamanya menatap layar elektronik (screen time) dapat memicu kegemukan. Kegemukan pada balita kurang disadari orang tua sebagai suatu masalah. Persepsi ibu berperan penting dalam mengelola asupan dan aktivitas fisik anak yang berpengaruh terhadap kegemukan balita.Tujuan: Tujuan penelitian ini adalah untuk mengetahui perbedaan aktivitas fisik, screen time, dan persepsi ibu terhadap kegemukan antara balita gemuk dan non-gemuk, serta besar risikonya.Metode: Penelitian observasional dengan pendekatan kasus-kontrol dilakukan di Kelurahan Bangetayu Kulon dan Kelurahan Jangli, Semarang melibatkan 58 balita berusia 24-59 bulan beserta ibunya. Pengumpulan data meliputi identitas sampel, berat badan (BB), tinggi badan (TB), aktivitas fisik (AF), screen time (ST), dan persepsi ibu terhadap kegemukan balita. Data BB dan TB diambil melalui pengukuran antropometri, data AF, ST, dan persepsi diambil melalui wawancara dengan instrumen kuesioner, dianalisis dengan uji Chi Square.Hasil: Aktivitas fisik kurang ditemukan pada kelompok gemuk sebanyak 20(68.9%) dan kelompok non-gemuk 11(37.9%). Screen time tinggi terdapat pada kelompok gemuk sebanyak 25(86.3%) dan kelompok non-gemuk 11(37.9%). Persepsi negatif ibu terhadap kegemukan ditemukan pada kelompok gemuk sebanyak 15(51,7%) dan kelompok non-gemuk 17(58,6%). Perbedaan aktivitas fisik, screen time, dan persepsi ibu terhadap kegemukan balita ditunjukkan berturut–turut oleh p=0,034 (OR= 3,63; 95% CI:1,22;10,78), p<0,001 (OR= 10,22; 95% CI:2,80;37,33), dan p=0,792.Simpulan: Terdapat perbedaan aktivitas fisik serta screen time antara balita gemuk dan non-gemuk. Namun, tidak terdapat perbedaan mengenai persepsi ibu terhadap kegemukan balita pada kedua kelompok. Balita dengan aktivitas fisik kurang berisiko 3,63 kali lebih besar untuk mengalami kegemukan, sementara balita dengan screen time yang tinggi berisiko 10,2 kali lebih besar untuk mengalami kegemukan.
Tingkat kecukupan zat gizi dan kadar hemoglobin pada atlet sepakbola
Authors: Nurdini Della Annisa , Probosari Enny
Published: January 2019

Latar Belakang : Hemoglobin berfungsi mengikat dan membawa oksigen dari paru untuk diedarkan ke seluruh tubuh. Kadar hemoglobin dapat dipengaruhi oleh asupan protein, zat besi, asam folat, vitamin C, vitamin A, seng, tembaga, tannin dan fitat.Tujuan : Menganalisis hubungan tingkat kecukupan zat gizi makanan di asrama atlet dengan kadar hemoglobin atlet sepakbola.Metode : Penelitian observasional dengan pendekatan cross sectional di Salatiga Training Centre, jumlah sampel 30 atlet usia 15 – 18 tahun dengan total sampling. Data yang dikumpulkan meliputi: identitas, berat badan, tinggi badan, dan recall 24 jam. Kadar hemoglobin diukur dengan cyanmethemoglobin. Data dianalisis dengan uji analisis depskripsi, analisis bivariat menggunakan uji pearson. Data diuji dengan regresi linier dengan α 5%.Hasil : Sebanyak 100% subjek mempunyai kadar hemoglobin normal. Pemacu penyerapan besi diantaranya adalah tingkat kecukupan protein, zat besi, asam folat, vitamin C, vitamin A, seng, tembaga dengan rerata asupan berturut-turut 64 ± 8,48 g, 72,23 ± 21,58 mg, 63,9 ± 11,34 mg, 78,33 ± 68,34 mg, 324,61 ± 130,3 mg,  53,5 ± 8,11 mg, dan 125,61 ± 0,1 mg, sedangkan asupan penghambat penyerapan zat besi yang terdiri dari fitat dan tanin dengan rerata 52,35 ± 2,1 mg dan 1,58 ± 0,3 mg.Simpulan : Penelitian ini menunjukkan tingkat kecukupan protein, zat besi, asam folat, vitamin C, dan seng kurang dari 100%, sedangkan tingkat kecukupan vitamin A dan tembaga lebih dari 100%. Terdapat hubungan antara tingkat kecukupan protein, zat besi, asam folat dan seng dengan kadar hemoglobin pada atlet sepakbola. Namun, tidak ada hubungan tingkat kecukupan vitamin C, vitamin A dan tembaga dengan kadar hemoglobin pada atlet sepakbola.
Dietary acid load, keseimbangan asam basa tubuh dan resistensi insulin pada remaja obesitas
Authors: Ramadhan Nauval Rifqy , Wijayanti Hartanti Sandi
Published: January 2019

Latar Belakang: Obesitas pada kelompok usia remaja telah menjadi salah satu masalah kesehatan yang menunjukkan peningkatan dari tahun ke tahun. Obesitas telah lama diketahui mempunyai hubungan patofisiologis dengan kondisi resistensi insulin. Diet dengan beban asam (Dietary Acid Load) tinggi, dapat menimbulkan gangguan keseimbangan asam basa tubuh, yang berpotensi menimbulkan resistensi insulin.Metode: Rancangan penelitian ini adalah Cross-Sectional dengan jumlah subjek sebanyak 38 remaja di lingkungan SMA Semarang. Skor PRAL dihitung sebagai indikator Dietary Acid Load, pH urin sebagai indikator keseimbangan asam basa, dan HOMA-IR sebagai indikator resistensi insulin. Dietary acid load dan pH urin ditetapkan sebagai variabel bebas dan resistensi insulin sebagai variabel terikat, sedangkan aktivitas fisik dan faktor asupan (energi, protein, lemak, karbohidrat) sebagai variabel perancu. Analisis bivariat menggunakan uji Rank Spearman. Analisis multivariat menggunakan analisis Multivariate Linear Backward Regression.Hasil: Ada hubungan antara skor PRAL dengan nilai HOMA-IR(r=0,886; p=0,000). Tidak ada hubungan antara pH urin dengan HOMA-IR. Uji multivariat menunjukkan dietary acid load (β=0,851; p=0,000; Adjusted R Square=82,5%) dan asupan lemak (β = 0,164; p = 0.029; Adjusted R Square = 82.5%) adalah variabel yang paling berhubungan secara signifikan terhadap nilai HOMA-IR Kesimpulan: Ada hubungan yang signifikan antara dietary acid load dengan resistensi insulin pada remaja obesitas.
Cookies tepung beras hitam dan kedelai hitam sebagai alternatif makanan selingan indeks glikemik rendah
Authors: Agustina Ayu Widiawati , Anjani Gemala
Published: January 2019

Latar Belakang: Diabetes mellitus merupakan penyakit karena kelainan metabolik yang jumlah penderitanya mengalami peningkatan tiap tahun. Penderita Diabetes Melitus tipe II membutuhkan makanan selingan untuk mencukupi kebutuhan gizi serta mengontrol kadar glukosa darah. Cookies tepung beras hitam dan kedelai hitam diharapkan memiliki indeks glikemik yang rendah sehingga dapat dijadikan alternatif makanan selingan penderita DM tipe II.Tujuan: Menganalisis kandungan protein, lemak, karbohidrat, serat, indeks glikemik, dan beban glikemik cookies tepung beras hitam dan tepung kedelai hitam.Metode : Penelitian eksperimental acak lengkap satu faktor yaitu formulasi tepung kedelai hitam sebesar 0%, 15%, 25%, dan 35%. Data kandungan zat gizi dianalisis menggunakan uji One Way Anova, dilanjutkan dengan Uji Tukey, sedangkan analisis tingkat penerimaan menggunakan Uji Friedman. Nilai indeks glikemik ditentukan menggunakan metode IUAC.Hasil : Tepung kedelai hitam berpengaruh nyata terhadap kadar protein, lemak, karbohidrat, dan serat. Nilai indeks glikemik dan beban glikemik dari cookies dengan formulasi 65% tepung beras hitam dan 35% kedelai hitam yaitu 39,74 dan 4,75. Uji organoleptik cookies tepung beras hitam dan kedelai hitam rendah pada tingkat penerimaan rasa yaitu sebesar 2,34.Simpulan : Cookies tepung beras hitam dan kedelai hitam memberikan hasil kadar protein,lemak, karbohidrat, dan serat yang berbeda secara bermakna. Tingkat penerimaan cookies tepung beras hitam dan kedelai hitam rendah pada kategori rasa. Cookies tepung beras hitam dan kedelai hitam memiliki indeks glikemik dan beban glikemik yang rendah yaitu sebesar 39,74 dan 4,75.
Resistensi insulin pada remaja stunted obesity usia 15-18 tahun di Kota Semarang
Authors: Nuraini Ismi Safitri , Sulchan Muhammad , Dieny Fillah Fithra
Published: January 2019

Latar Belakang: Stunted obesity merupakan masalah gizi yang masih belum banyak mendapat perhatian walaupun terkait dengan berbagai penyakit degeneratif dan penyakit tidak menular lainnya. Remaja stunted obesity memiliki kadar glukosa, kadar insulin, resistensi insulin yang lebih tinggi, dan menurunnya fungsi sel-β pankreas dari pada remaja stunted non-obese. Resistensi insulin merupakan salah satu kriteria klinis sindrom metabolik yang telah banyak muncul sejak usia remaja. Tujuan dari peenlitian ini adalah menganilisi perbedaan resistensi insulin antar kelompok stunted obese dan non-stunted obese.Metode: Penelitian pada remaja usia 15 hingga 18 tahun di SMA Kota Semarang dengan persebaran wilayah dibagi menjadi dua wilayah yaitu urban dan suburban. Desain penelitian cross sectional dengan jumlah subjek 52 remaja menggunakan metode consecutive sampling. Nilai resistensi insulin didapatkan berdasarkan hasil perhitungan homeostasis model assessment insulin resistance (HOMA-IR). Perbedaan nilai HOMA-IR dianalisis menggunakan uji Mann Whitney.Hasil: Ditemukan kejadian resistensi insulin pada kedua kelompok sama besar yaitu 96,1%. Rerata nilai HOMA-IR pada remaja stunted obesity sebesar 5,37±4.86 dan non-stunted obese sebesar 4,99±2.02, tetapi secara statistik tidak terbukti bemakna (p=0,22).Kesimpulan: Kedua kelompok mempunyai kecenderungan yang sama untuk  mengalami resistensi insulin dengan p=0,22..
Rasio trigliserida / high density lipoprotein-cholesterol pada remaja stunted obesity usia 15-18 tahun di Kota Semarang
Authors: Afifah Yuni Nur , Sulchan Muhammad , Nissa Choirun
Published: January 2019

Latar belakang: Stunted menjadi permasalahan gizi di Indonesia. Individu stunted memiliki risiko 3,4 kali untuk menjadi obesitas dibanding individu non-stunted. Remaja dengan stunted obesity memiliki risiko tinggi terhadap sindrom metabolik dan gangguan metabolik lainnya. Rasio trigliserida/High Density Lipoprotein-Cholesterol (TG/HDL-C) dapat mengidentifikasi individu dengan risiko sindrom metabolik dan gangguan kardiometabolik. Penelitian ini bertujuan untuk mengetahui perbedaan rasio TG/HDL-C pada remaja stunted obesity dan non-stunted obesity di Kota Semarang.Metode: Penelitian ini menggunakan rancangan cross sectional pada 2 kelompok: remaja stunted obesity dan non-stunted obesity. Total subjek yaitu 2299 remaja usia 15-18 tahun dengan skrining yang dilakukan secara random terhadap 4 sekolah dari area urban dan suburban di Kota Semarang.  Penentuan status gizi berdasarkan tinggi badan menurut umur, Indeks Massa Tubuh (IMT) menurut umur, dan lingkar pinggang. Pengukuran kadar trigliserida dan HDL-C menggunakan metode enzimatik kolorimetri. Analisis data menggunakan uji t independen.Hasil: Angka kejadian obesitas pada remaja sebesar 8,52%, terdiri dari stunted obesity (1,96%) dan non-stunted obesity (6,57%). Sebanyak 26,93% remaja memiliki kadar trigliserida tinggi dan 75,00% remaja memiliki kadar HDL-C rendah. Ditemukan 80,80% remaja dengan rasio TG/HDL-C ≥1,70. Rerata kadar trigliserida, HDL-C, dan rasio TG/HDL-C pada remaja stunted obesity lebih tinggi dari kelompok remaja non-stunted obesity dimana tidak bermakna. Simpulan: Rerata rasio TG/HDL-C pada kelompok remaja stunted obesity lebih tinggi dibanding kelompok remaja non-stunted obesity (p=0,745)