bluuebunny/crossref_metadata_2025 huggingface dataset:
Wearables and Social Signal Processing for Smarter Public Presentations
Authors: Mihoub Alaeddine , Lefebvre Grégoire
Published: March 2019

Social Signal Processing techniques have given the opportunity to analyze in-depth human behavior in social face-to-face interactions. With recent advancements, it is henceforth possible to use these techniques to augment social interactions, especially human behavior in oral presentations. The goal of this study is to train a computational model able to provide a relevant feedback to a public speaker concerning his/her coverbal communication. Hence, the role of this model is to augment the social intelligence of the orator and then the relevance of his/her presentation. To this end, we present an original interaction setting in which the speaker is equipped with only wearable devices. Several coverbal modalities have been extracted and automatically annotated namely speech volume, intonation, speech rate, eye gaze, hand gestures, and body movements. In this article, which is an extension of our previous article published in IUI’17, we compare our Dynamic Bayesian Network design to classical J48/Multi-Layer Perceptron/Support Vector Machine classifiers, propose a subjective evaluation of presenter skills with a discussion in regards to our automatic evaluation, and we add a complementary study about using DBScan versus
k
-means algorithm in the design process of our Dynamic Bayesian Network.
How to instantaneously improve your speaking voice
Authors: Yaffe Philip
Published: March 2019

Each "Communication Corner" essay is self-contained; however, they build on each other. For best results, before reading this essay and doing the exercise, go to the first essay "How an Ugly Duckling Became a Swan," then read each succeeding essay.

Although we spend much more time speaking than we do writing, the fact remains that most people speak very poorly. Phil Yaffe provides some tips on how to purposely redesign your articulation.
Tension Test for Axially Vibrated Prestressing Fine‐Rolled Screw‐Threaded Steel Bars Based on Thread‐Contact Connection
Authors: Zhong Xingu , Zhang Tianyu , Zhao Chao , Shu Xiaojuan , Shen Mingyan , Chen Yohchia Frank
Published: March 2019

The interface between anchor plate and anchorage nut can be considered as a coupling spring whose stiffness is essentially the contact stiffness related to normal force at the contact surface, thus removing the usual assumption of fixed connection. The nut threads and steel bar are also connected with a coupling spring with the stiffness determined based on the threads treated as cantilever components. An analytical model was developed to assess the axial vibration of an anchorage system consisting of prestressing fine‐rolled screw‐threaded steel bars (P/S FSSBs). Both laboratory model and field tests show that the contact stiffness between anchor plate and anchorage nut has good a linear relationship with the effective tension of prestressed tendons. The vibration model was used to obtain the natural frequency and tensile force of a P/S FSSB. It is shown to be feasible and practical. According to the analytical model and test method presented in this paper, the proposed tension tester for P/S FSSBs possesses the features of repeated use, rapid testing, and minimized impact on the construction and is thus suggested for wider practical applications.
Comparative Efficacy and Tolerability of Neoadjuvant Immunotherapy Regimens for Patients with HER2-Positive Breast Cancer: A Network Meta-Analysis
Authors: Wu Di , Chen Tiejun , Jiang Han , Duan Chongyang , Zhang Xinjian , Lin Yiguang , Chen Size , Wu Fenfang
Published: March 2019

This network meta-analysis addresses the need for evidence-based best-practice treatment regimens for HER2-positive breast cancer. We compared the relative efficacy and tolerability of currently available HER2-positive neoadjuvant immunotherapy regimens based on systematic searches of available randomized controlled trials (RCTs) data. Based on intention-to-treat principle, pathological complete response (pCR), overall serious adverse events (SAEs), and breast-conserving surgery (BCS) rate were analyzed using random-effect, Bayesian network meta-analysis, and standard pairwise meta-analysis. 16 RCTs (3868 patients) were included. Analyzed treatment regimens were as follows: chemotherapy+trastuzumab+pertuzumab (CTP), trastuzumab emtansine+pertuzumab (MP), chemotherapy+trastuzumab (CT), chemotherapy+pertuzumab (CP), trastuzumab+pertuzumab (TP), chemotherapy+trastuzumab+lapatinib (CTL), and chemotherapy+lapatinib (CL), and chemotherapy (C) alone. We found that, for the chance of achieving pCR, CTP was ranked first (SUCRA: 97%), followed by CTL, MP, and CT (SUCRA: 80%, 75%, and 55%, resp.). MP provided the safest regimen (SUCRA: 97%), then TP, C, and TPC (SUCRA: 82%, 76%, and 47%, resp.). CTL proved the most toxic therapy (SUCRA: 7%). No significant difference between neoadjuvant regimens was identified for BCS. Hormone receptor status did not impact ORs for pCR in any regimen. In conclusion, our findings support CTP as the optimum neoadjuvant regimen for HER2-positive breast cancer, with the best pCR and acceptable toxicity compared with CT. MP provides a therapeutic option for patients with poor performance status.
A Novel Approach for RPL Assessment Based on the Objective Function and Trickle Optimizations
Authors: Lamaazi Hanane , Benamar Nabil
Published: March 2019

The ROLL working group proposed the RPL (IPv6 routing protocol for low-power and lossy networks) to respond to the requirements of low-power and lossy networks (LLNs). In this paper, we propose a new approach to assess the RPL performances based on its main components, namely, the objective function (OF) and the trickle algorithm. To this end, we compare between the RPL-EC (RPL based combined ETX and energy consumption) and the RPL-FL (RPL based on the flexible trickle algorithm). This paper compares the two implementations to assess the weight of each proposed improvement against the standard RPL. The results show that RPL performances are greatly influenced by the change of both the objective function and trickle algorithm. RPL-FL provides best values in terms of overhead, packet delivery ratio (PDR), and energy consumption, while RPL-EC acts better with the convergence time and the network lifetime compared to the standard RPL.
Design and Optimization of Colorimetric Paper-Based Analytical Device for Rapid Detection of Allopurinol in Herbal Medicine
Authors: Pratiwi Rimadani , Septyani Rieda Nurwulan , Febriany Rossi , Saputri Febrina Amelia , Nuwarda Rina Fajri
Published: March 2019

Traditional herbal medicine in Indonesia is still in great demand and popular in society. The Indonesian government regulations state that herbal medicine should not contain chemical drug due to the toxic effect of uncontrolled consumption. Allopurinol is one of the drugs commonly added to herbal medicine for the treatment of chronic gout. Paper-based analytical device is one of the latest forms of analysis that has been widely used for the identification of chemical elements, environmental contamination, bacteria, and many more. In this study, experiments were conducted using Whatman filter paper No. 1, No. 2, and No. 4 and Whatman chromatography as a paper, and 9 colorimetric reagents were tested for allopurinol detection in herbal medicine. There were 5 specific reagents that reacted positively with allopurinol and only 3 reagents that can be applied to the paper, that is, Folin-Ciocalteu, Tollens, and p-DAB reagent. The results of the optimization show that the most optimal immersion time was 60 minutes with a drying time of 30 minutes at 50°C. Each filter paper has different characteristic; however, there was no significant difference when all of the papers were used as PAD for allopurinol detection.
Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease
Authors: Schulte L. , Hohwieler M. , Müller M. , Klaus J.
Published: March 2019

Inflammatory bowel diseases (IBDs) include colitis ulcerosa and Crohn’s disease, besides the rare microscopic colitis. Both diseases show a long-lasting, relapsing-remitting, or even chronic active course with tremendous impact on quality of life. IBDs frequently cause disability, surgical interventions, and high costs; as in other autoimmune diseases, their prevalent occurrence at an early phase of life raises the burden on health care systems. Unfortunately, our understanding of the pathogenesis is still incomplete and treatment therefore largely focuses on suppressing the resulting excessive inflammation. One obstacle for deciphering the causative processes is the scarcity of models that parallel the development of the disease, since intestinal inflammation is mostly induced artificially; moreover, the intestinal epithelium, which strongly contributes to IBD pathogenesis, is difficult to assess. Recently, the development of intestinal epithelial organoids has overcome many of those problems. Here, we give an overview on the current understanding of the pathogenesis of IBDs with reference to the limitations of previous well-established experimental models. We highlight the advantages and detriments of recent organoid-based experimental setups within the IBD field and suggest possible future applications.
Analyzing the Influence of Modic Changes on Patients with Lower Back Pain Undergoing Conservative Treatment
Authors: Chen Yufeng , Yang Huilin , Zhang Lianfang , Wang Yue , Zou Jun
Published: March 2019

Objective. This study aimed to investigate if the presence of Modic changes (MCs) was correlated with lower back pain (LBP) and LBP-related disability in patients who underwent nonsurgical treatment. Methods. In this study, 129 patients who experienced consecutive LBP and underwent lumbar spine magnetic resonance imaging in our institute were divided into three groups according to the presence or type of MCs. The Oswestry Disability Index (ODI) and visual analog scale (VAS) were used to assess the outcomes of the treatment. Results. Based on the achieved results, there was no significant difference between three groups before treatment (P>0.05). Three months after undergoing nonsurgical treatment, the rates of improved ODI and VAS scores were statistically significantly different (P=0.014,  0.023). After an additional 3 months of treatment, in patients with Modic type I changes, the symptoms significantly improved in comparison with those 3 months prior (P=0.037,  0.026), while that improvement did not occur in patients with Modic type II changes (P>0.05). Conclusions. The existence of MCs affects the outcomes of nonsurgical treatment in patients with LBP. However, symptoms can be improved after an additional round of treatment for Modic type I changes, while this is not confirmed for Modic type II changes.
Chronic, Stromal Foreign Body of Presumed Human Origin, following Corneal Abrasion
Authors: Soon Alexander K. , Mather Rookaya
Published: March 2019

A 30-year-old woman presented with left eye pain and photophobia for over eight weeks. A hair was found to be embedded obliquely within the corneal stroma with overlying reepithelialization. The foreign body had been quiescent for over four years prior to any ocular symptoms. Successful removal of the hair was performed using local anesthetic, jeweler’s forceps, a microblade, and a thirty-gauge needle with good visual outcome. We report an interesting case of an acute exacerbation of a previously quiescent, chronic corneal foreign body secondary to what we presume to be human hair following trauma, with only three other cases in the English literature.
Antiferromagnetic Phase Transition in Cr2As via Anisotropy of Exchange Interactions
Authors: Valkov V. I. , Golovchan A. V. , Aparajita Upali , Roslyak Oleksiy
Published: March 2019

The electronic structure of antiferromagnetic Cr2As is investigated. Anisotropy of exchange interactions between chrome sublattices is determined JXCrI−CrII=4.77 meV,JYCrI−CrII=−6.36 meV. The behavior of exchange integrals from the magnetic structure is analyzed.
Removal of Synthetic Azo Dye Using Bimetallic Nickel-Iron Nanoparticles
Authors: Foster Shelby L. , Estoque Katie , Voecks Michael , Rentz Nikki , Greenlee Lauren F.
Published: March 2019

Bimetallic nanoparticles comprised of iron (Fe) and nickel (Ni) were investigated for the removal of an azo dye contaminant in water. Morphology (core shell and alloy) and metal molar ratio (Ni2Fe10, Ni5Fe10, and Ni10Fe10) were tested as key nanoparticle properties. The shelf life of the nanoparticles was tested over a 3-week period, and the effect of initial nanoparticle concentration on dye removal was evaluated. The highest initial nanoparticle concentration (1000 mg/L) showed consistent Orange G removal and the greatest extent of dye removal, as compared to the other tested concentrations (i.e., 750 mg/L, 500 mg/L, and 250 mg/L) for the same nanoparticle morphology and metal molar ratio. The metal molar ratio significantly affected the performance of the core shell morphology, where overall dye removal was found to be 66%, 89%, and 98% with an increasing molar ratio (Ni2Fe10 → Ni5Fe10 → Ni10Fe10). In contrast, the overall removal of the dye for all molar ratios of the alloy nanoparticles only resulted in a variability of ±0.005%. When stored in water for 3 weeks, core shell nanoparticles lost reactivity with an average>17% loss in removal with each passing week. However, the alloy nanoparticles were able to continually remove Orange G from solution after 3 weeks of storage to ~97% when used at a starting nanoparticle concentration of 1000 mg/L. Overall, the Ni2Fe10, Ni5Fe10, and Ni10Fe10 alloy nanoparticles with a starting nanoparticle concentration of 1000 mg/L resulted in the greatest dye removal of 97%, 99%, and 98%, respectively. Kinetic rate models were used to analyze dye removal rate constants as a function of nanoparticle properties. Kinetic rate models were seen to differ from core shell (first-order kinetics) to alloy morphology (second-order kinetics). Alloy nanoparticles resulted in as high as X kinetic rate constant, and core shell nanoparticles resulted in as high as XX kinetic rate constant. Metal leaching from the nanoparticles was investigated; alloy nanoparticles resulted in leaching of 3% Fe and 5% Ni which is similar to core shell leaching of 3.2% Fe and 4.3% Ni from the Fe10Ni10 nanoparticles.
Safety and Feasibility of Repeated and Transient Blood–Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma
Authors: Idbaih Ahmed , Canney Michael , Belin Lisa , Desseaux Carole , Vignot Alexandre , Bouchoux Guillaume , Asquier Nicolas , Law-Ye Bruno , Leclercq Delphine , Bissery Anne , De Rycke Yann , Trosch Clementine , Capelle Laurent , Sanson Marc , Hoang-Xuan Khe , Dehais Caroline , Houillier Caroline , Laigle-Donadey Florence , Mathon Bertrand , André Arthur , Lafon Cyril , Chapelon Jean-Yves , Delattre Jean-Yves , Carpentier Alexandre
Published: March 2019

Purpose:

The blood–brain barrier (BBB) limits the efficacy of drug therapies for glioblastoma (GBM). Preclinical data indicate that low-intensity pulsed ultrasound (LIPU) can transiently disrupt the BBB and increase intracerebral drug concentrations.

Patients and Methods:

A first-in-man, single-arm, single-center trial (NCT02253212) was initiated to investigate the transient disruption of the BBB in patients with recurrent GBM. Patients were implanted with a 1-MHz, 11.5-mm diameter cranial ultrasound device (SonoCloud-1, CarThera). The device was activated monthly to transiently disrupt the BBB before intravenous carboplatin chemotherapy.

Results:

Between 2014 and 2016, 21 patients were registered for the study and implanted with the SonoCloud-1; 19 patients received at least one sonication. In 65 ultrasound sessions, BBB disruption was visible on T1w MRI for 52 sonications. Treatment-related adverse events observed were transient and manageable: a transient edema at H1 and at D15. No carboplatin-related neurotoxicity was observed. Patients with no or poor BBB disruption (n = 8) visible on MRI had a median progression-free survival (PFS) of 2.73 months, and a median overall survival (OS) of 8.64 months. Patients with clear BBB disruption (n = 11) had a median PFS of 4.11 months, and a median OS of 12.94 months.

Conclusions:

SonoCloud-1 treatments were well tolerated and may increase the effectiveness of systemic drug therapies, such as carboplatin, in the brain without inducing neurotoxicity.

See related commentary by Sonabend and Stupp, p. 3750
T Cells Specific for an Unconventional Natural Antigen Fail to Recognize Leukemic Cells
Authors: Pont Margot J. , Oostvogels Rimke , van Bergen Cornelis A.M. , van der Meijden Edith D. , Honders Maria W. , Bliss Sophie , Jongsma Marlieke L.M. , Lokhorst Henk M. , Falkenburg J.H. Frederik , Mutis Tuna , Griffioen Marieke , Spaapen Robbert M.
Published: March 2019

MHC-bound peptides from aberrant proteins may be a specific immunotherapeutic target on cancer cells. Because of difficulties in identifying such antigens, viral or model antigens have so far been used to study their biological relevance. We here identify a naturally existing human T-cell epitope derived from a truncated protein. The antigenic peptide is derived from the gene TTK only through an alternative transcript containing a premature termination codon that may target the transcript for nonsense-mediated decay (NMD). This antigen is recognized by HLA-A*02:01–restricted CD8+ T cells derived from an allotransplanted leukemia patient. Functional analyses showed that these T cells failed to recognize several HLA-matched primary leukemic cells that expressed the alternative TTK transcript. Conventional antigen processing and presentation were not affected, suggesting that leukemic cells modify the generation of antigens processed from aberrant proteins. This natural TTK epitope provides insights in the source of transcripts producing antigenic epitopes in healthy and leukemic cells. Our data underscore potential pitfalls of targeting NMD-derived or other unconventionally generated epitopes as immunotherapeutic approach.
An Insight into the Utility of Sub-Categorisation of Atypia of Undetermined Significance for Risk Stratification: A Retrospective Study on an Indian Cohort with Histopathological Correlation
Authors: Roy Sanjeet , Prabhu Anne Jennifer , Abraham Deepak Thomas , Mazhuvanchary Jacob Paul , Manipadam Marie Therese
Published: March 2019

Background: Atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) criterion in thyroid fine-needle aspirates (FNAs) has been a heterogeneous entity with much inter-observer variation. Sub-categorisation of AUS/FLUS has been observed to play an effective role in risk stratification. We aimed to validate AUS/FLUS sub-categorisation in correlation with the spectrum of malignancy. Study Design: Subjects included patients with AUS/FLUS diagnosed between January 2015 and December 2016. AUS/FLUS cases were sub-categorised into those exhibiting (1) architectural atypia, (2) cytological atypia, (3) architectural and cytological atypia, (4) AUS with Hürthle cells, and (5) AUS not otherwise specified (AUS-NOS). Each sub-category was correlated with their corresponding incidence of malignancy in surgical resections. Result: The overall incidence of AUS/FLUS in our centre was 13% (132/1,018). On retrospective review of 117 patients with AUS/FLUS, smears with cytological atypia showed a higher incidence of malignancy (78.3%) than those with architectural atypia (75.3%). AUS/FLUS cases with both cytological and architectural atypia had a malignancy rate of 71.4%. Conclusion: AUS/FLUS cases with cytological atypia had a higher risk of malignancy than those with architectural atypia. The sub-categorisation of AUS/FLUS is diagnostically important for the proper risk stratification of patients.
Bariatric Surgery Is a Safe and Effective Option for Patients with Inflammatory Bowel Diseases: A Case Series and Systematic Review of the Literature
Authors: Hudson Joshua L. , Barnes Edward L. , Herfarth Hans H. , Isaacs Kim L. , Jain Animesh
Published: March 2019

Background: Questions remain regarding both the safety and efficacy of bariatric surgery in patients with inflammatory bowel diseases (IBD), including the effects of bariatric surgery on the course of disease. We report a case series from a tertiary care IBD referral center and review the existing literature regarding the safety and efficacy of bariatric surgery in IBD patients. Objectives: Examine the safety and efficacy of bariatric surgery in IBD patients. Explore possible effects of weight loss on postoperative IBD course. Method: We performed a retrospective review of patients at our center undergoing bariatric surgery with a concurrent IBD diagnosis, collecting baseline characteristics, surgery type, and postoperative course (including IBD outcomes and weight loss). Data from these patients were combined with available data from the existing literature to calculate standardized means with standard error, variance, and confidence intervals (CI). Results: Data from 13 patients who had undergone bariatric surgery at our facility were combined with data from 8 other studies to create a study population of 101 patients. Of these, 61 had Crohn’s disease, 37 ulcerative colitis, and 3 IBD-unspecified, with a mean preoperative BMI of 44.2 (95% CI 42.9–45.7). Following surgery, a mean excess weight loss of 68.4% was demonstrated (95% CI, 65.7–71.2). Of the 101 patients, 22 experienced early and 20 experienced late postoperative complications. Postoperatively, 10 patients experienced a flare of IBD, 20 remained in remission, and 7 patients were able to discontinue immunosuppressive therapy. Conclusions: Based on available studies, bariatric surgery appears to be both an effective and safe option for weight loss in patients with IBD.
Laparoscopic Decortication of Simple Renal Cysts: A Systematic Review and Meta-Analysis to Determine Efficacy and Safety of this Procedure
Authors: Nalagatla Sarika , Manson Ross , McLennan Rachel , Somani Bhaskar , Aboumarzouk Omar M.
Published: March 2019

Objectives: To determine the efficacy and safety of laparoscopic deroofing of symptomatic simple renal cysts. Methods: A Cochrane style systematic review was conducted on published literature from 1990 to 2017, to include case series and randomised controlled trials. A pooled meta-analysis was conducted. Results: A total of 696 patients who had laparoscopic deroofing of their simple renal cysts were identified. Complete radiological resolution was seen in 96% of patients with 95% of patients completely symptoms free. Less than 1% of patients had intra-operative complications and 1.4% developed postoperative complications. Conclusions: Cumulative analysis of the literature examining the role of laparoscopic decortication in the management of symptomatic simple renal cysts reveals that the procedure is highly efficacious to relieve symptoms. The procedure was also associated with a significant radiological success rate (96.3%). It was also shown to be safe, with a low complication rate. We deduced a protocol following this systematic review for the management of symptomatic renal cyst in an aim to help select patients that would benefit from laparoscopic decortication.
Hyperosmolality, High Blood Pressure, and Decreased Estimated Glomerular Filtration Rate in US Adolescents, National Health and Nutrition Examination Survey 1999–2012
Authors: Chmielewski Jennifer , Khalsa Dev Darshan , Carmody J. Bryan
Published: March 2019

Background: Experimental evidence suggests that hyperosmolality may be a causative factor in the development of both salt-sensitive hypertension and chronic kidney disease (CKD). There are no population-wide studies in young persons to assess the relationships among these factors. Objective: To determine the association of serum osmolality and serum sodium with high systolic blood pressure (SBP) and decreased estimated glomerular filtration rate (eGFR) among a nationally representative population of adolescents. Method: Relevant data among participants ages 12–14 were obtained from the National Health and Nutrition Examination Survey cycles 1999–2012. Serum osmolality was calculated using the Worthley equation. eGFR was calculated using the Counahan-Barratt equation, and values < 90 mL/min/1.73 m2 were considered decreased. High SBP was defined as SBP ≥95th percentile for age, height, and sex. Results: A total of 4,168 adolescents were analyzed (representative population: 10,464,592). Adolescents with serum osmolality ≥290 mOsm/kg and/or serum sodium ≥143 mmol/L had increased odds for both high SBP (serum osmolality ≥290 mOsm/kg: OR 2.04; 95% CI 1.03–4.02; sodium ≥143 mmol/L: OR 4.36; 95% CI 1.58–12.04) and decreased eGFR (serum osmolality ≥290 mOsm/kg: OR 1.61; 95% CI 1.18–2.21; sodium ≥143 mmol/L: OR 3.27; 95% CI 1.77–6.03) when compared to participants with values below these thresholds. These thresholds remained significant even after multivariable adjustment. Conclusion: Among adolescents in a nationally representative survey, hypernatremia and hyperosmolality were associated with high SBP and decreased eGFR. These findings may support the hypothesis that an imbalance of salt and water contribute to hypertension and CKD.
Ovarian Teratoid Carcinosarcoma Is an Aggressive Tumor of Probable Mullerian Derivation with a Carcinosarcomatous and Mixed Germ-Cell Morphology
Authors: Fox Courtney , Allen Nichole , Schimp Veronica , Maksem John
Published: March 2019

Ovarian carcinosarcoma is also referred to as malignant mixed Mullerian tumor (MMMT). It is a rare neoplasm, and although it represents less than 5% of malignant ovarian tumors, it remains generally well-known among clinicians and pathologists. Rarer yet is ovarian teratoid carcinosarcoma, defined as carcinosarcoma with the added feature of immature neuroectodermal tissue, with or without elements of primitive germ cell tumor. To our knowledge, six ovarian teratoid carcinosarcomas have been reported in the literature [Matsuura et al. J Obstet Gynaecol Res. 2010 Aug; 36(4): 907–11]. These tumors resemble nasopharyngeal tumors of the same name. We report a 55-year-old woman seen at Orlando Health’s division of gynecological oncology whose pathology showed ovarian teratoid carcinosarcoma, and present what we believe to be a seventh report of this entity.
Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy
Authors: Yamada Keisaku , Nakamura Masanao , Yamamura Takeshi , Maeda Keiko , Sawada Tsunaki , Mizutani Yasuyuki , Ishikawa Takuya , Furukawa Kazuhiro , Ohno Eizaburo , Miyahara Ryoji , Kawashima Hiroki , Hotta Naoki , Hirooka Yoshiki
Published: March 2019

Background: There are a number of reports that demonstrate the high diagnostic accuracy of colon capsule endoscopy (CCE) for polyp detection. However, some colorectal polyps are missed on CCE, and the clinical factors influencing those missed polyps are still unknown. Objective: The aim of this study was to elucidate the clinical factors related to missing colorectal polyp on CCE by using per-polyp analysis. Methods: We performed a retrospective multi-center study of 53 consecutive patients who underwent both CCE and colonoscopy (CS) within 3 months from January 2014 to ­December 2017. Of those patients, we analyzed 151 polyps detected on CCE, and 149 polyps detected on CS diagnosed as neoplasm according to histopathological result. Results: The capsule excretion rate was 81%. One hundred three polyps were detected on both CS and CCE, 46 polyps (31%) were missed on CCE, and 48 polyps were considered false positive on CCE when CS result was considered as the gold standard. Per-polyp sensitivity and positive predictive value on CCE were 69.1 and 68%. On multiple logistic analysis, only the segmental transit time on CCE was identified as the independent factor influencing missed polyp on CCE. Conclusions: The clinical factor related to missing colorectal polyp on CCE was the segmental transit time.
High-Level Mupirocin Resistance in Staphylococcus spp. among Health Care Workers in a Tertiary Care Hospital
Authors: Kavitha E. , Srikumar R.
Published: March 2019

Background: Nasal carriage of Staphylococcus aureus is very common among health care workers, and treatment with mupirocin is one of the choicest antibiotics available. But with the rampant usage of mupirocin like other antibiotics, the emergence of mupirocin resistance is also on rise. This resistance is both low level as well as high level among the isolated strains. Aim: To screen for the high-level mupirocin resistance among the isolated Staphylococcus strains by Kirby Bauer disk diffusion method. Materials and Methods: A total of 200 clinical isolates were tested for high level mupirocin resistance by disk diffusion method using Himedia disks. Results: Among the 200 nasal swabs, 26 (13%) showed growth of S. aureus, whereas 174 (87%) showed the growth of coagulase negative staphylococcus (CONS) spp. Mupirocin resistance was observed only among CONS spp, which was 15% for low-level mupirocin and 8% for high-level mupirocin resistance. No mupirocin resistance was observed among the Staphylococcus spp. Conclusion: The identification of Mupirocin resistance will guide us to utilize the antibiotic in a judicious way to treat the nasal carriage effectively.
Prostate-Specific Antigen Within the Reference Range, Subclinical Coronary Atherosclerosis, and Cardiovascular Mortality
Authors: Chang Yoosoo , Kim Jae Heon , Noh Jin-Won , Cho Young-Sam , Park Heung Jae , Joo Kwan Joong , Ryu Seungho
Published: March 2019

Rationale:

Although PSA (prostate-specific antigen)—a tumor marker for prostate cancer—has been reported to be associated with cardiovascular disease (CVD) risk factors, studies on the association of PSA with subclinical and clinical CVD remain limited.

Objective:

We examined the association of total serum PSA within the reference range with coronary artery calcium (CAC) score and CVD mortality.

Methods and Results:

A cross-sectional study was performed in 88 203 Korean men who underwent a health checkup exam including cardiac tomography estimation of CAC score. Logistic regression model was used to calculate odds ratios with 95% CIs for prevalent CAC. PSA levels were inversely associated with the presence of CAC. After adjusting for potential confounders, multivariable-adjusted odds ratio (95% CIs) for prevalent CAC comparing PSA quartiles 2, 3, and 4 to the first quartile were 0.96 (0.90–1.01), 0.88 (0.83–0.93), and 0.85 (0.80–0.90), respectively (
P
for trend, <0.001). A cohort study was performed in 243 435 Korean men with a mean age of 39.3 years, PSA values of <4.0 ng/mL, and without known CVD or prostate disease who were followed up with for ≤14 years for CVD mortality (median, 7.3 years). CVD deaths were ascertained through linkage to national death records. Hazard ratios and 95% CIs for CVD mortality were estimated using Cox proportional hazards regression analyses. During 1 829 070.1 person-years of follow-up, 336 CVD deaths were identified. After adjustment for potential confounders, multivariable-adjusted hazard ratios (95% CIs) for CVD mortality comparing PSA quartiles 2, 3, and 4 to the lowest quartile were 0.90 (0.66–1.22), 0.79 (0.58–1.08), and 0.69 (0.51–0.93), respectively.

Conclusions:

Serum total PSA levels within the reference range showed an inverse association with subclinical atherosclerosis and CVD mortality in young and middle-aged Korean men, indicating a possible role of PSA as a predictive marker for subclinical and clinical CVD.
Diversity of Manota Williston (Diptera: Mycetophilidae) in a Malaysian rainforest: description of twenty-seven new sympatric species
Authors: HIPPA HEIKKI
Published: March 2019

The following 27 strictly sympatric, new species of Manota are described from Malaysia: M. acutangula, M. angustata, M. biloba, M. calcarata, M. cerciflex, M. clausa, M. curvata, M. duplex, M. fera, M. ferrata, M. globigera, M. heptacantha, M. horrida, M. oligochaeta, M. ovata, M. pappi, M. pectinata, M. perpusilla, M. plusiochaeta, M. pollex, M. procera, M. roslii, M. simplex, M. spadix, M. transversa, M. ulu, and M. yongi. A key for the identification of all the Oriental and Palaearctic species of Manota is given.
A new species of Coleophora (Lepidoptera: Coleophoridae: Coleophorinae) from the Galápagos Islands, Ecuador
Authors: LANDRY JEAN-FRANÇOIS
Published: March 2019

Coleophora darwini sp. nov., is described from the Galápagos Islands. This is the first record of the family Coleophoridae for the Galápagos. Adults were reared from larvae found mining leaves of Amaranthus andersonii Howell (Amaranthaceae) on Pinzón Island. Adults of the species also were collected at light on the islands of Española and Pinta. Coleophora darwini is similar to C. intexta Meyrick, 1917 from Peru. Adults, and male and female genitalia of both species, as well as the larval case of C. darwini, are illustrated and morphological characters distinguishing the two species are presented. A lectotype is formally designated for C. intexta.
Four palaeonemerteans (Nemertea: Anopla) from a tidal flat in middle Honshu, Japan
Authors: KAJIHARA HIROSHI
Published: March 2019

Four species of palaeonemerteans, including Carinina plecta sp. nov., Callinera nishikawai sp. nov., Hubrechtella ijimai comb. nov., and Hubrechtella kimuraorum sp. nov., are described from the Pacific coast of Honshu Island, Japan. The genus Coeia Takakura, 1922 is considered to be a subjective junior synonym of Hubrechtella Bergendal, 1902. Carinina plecta sp. nov. can be distinguished from other congeners by possessing a rhynchocoel wall principally composed of interwoven circular and longitudinal muscle fibres, a condition similar to that in another palaeonemertean genus, Carinoma, as well as certain members in the Hoplonemertea. Callinera nishikawai sp. nov. possesses a remarkable stylet-like apparatus in the proboscis, a feature that has never been reported for any other palaeonemertean. The characteristic ‘tail’ in Hubrechtella (= Coeia) ijimai comb. nov. can be regarded as a heterochronic retention of the structure that appears only in juveniles of other congeners. Hubrechtella kimuraorum sp. nov. has a broad U-shaped blood lacuna in the foregut region before it ramifies into a vascular plexus.
A new species of Plectromerus Haldeman (Coleoptera: Cerambycidae) from Navassa Island, Greater Antilles
Authors: NEARNS EUGENIO H. , STEINER WARREN E.
Published: March 2019

A new species, Plectromerus navassae (Coleoptera: Cerambycidae: Cerambycinae: Curiini), from Navassa Island, Greater Antilles, is described. Features distinguishing the new species from its congeners are presented.Una nueva especie, Plectromerus navassae (Coleoptera: Cerambycidae: Cerambycinae: Curiini), de la Isla Navassa, Antillas Mayores, se describe. Se incluyen características para diferenciar esta especie de otros miembros del género.
A new species of the genus Hyidiothrips (Thysanoptera: Phlaeothripidae) from China
Authors: WANG JUN , TONG XIAO-LI , ZHANG WEI-QIU
Published: March 2019

Hyidiothrips guangdongensis sp. n., a new species of the subfamily Phlaeothripinae (Thysanoptera, Phlaeothripidae) is described from China. The new species is similar to Hyidiothrips japonicus Okajima, but can be distinguished from the latter by the following features: pronotum longer than head; antennal segment I brown, segment II yellowish and segments III–VII dark brown; median sclerite of pelta blunt posteriorly, separated from anterior sclerite, posterior sclerite distinctly divided into two lateral plates in female. The type specimens are deposited at the Insect Collection, Department of Entomology, South China Agricultural University.
Description of a new species of Anteon Jurine from the People’s Republic of China and of the male of Anteon fidum Olmi (Hymenoptera: Dryinidae)
Authors: XU ZAIFU , OLMI MASSIMO , HE JUNHUA
Published: March 2019

A new species, Anteon amabilis, is described from the People’s Republic of China (Zhejiang Prov., Baishanzu). Also Dryinidae were collected and studied from Xizang Zhang Autonomous Region (= Tibet) for the first time that resulted in the discovery and description of the previously unknown male of Anteon fidum Olmi. Additions to the Xu et al. (2000) key are provided so that these species can be discriminated.
Four new species of the genus Diaphorus (Diptera: Dolichopodidae) from China
Authors: WANG MENGQING , YANG DING , GROOTAERT PATRICK
Published: March 2019

Four species of Diaphorus Meigen are described as new to science: Diaphorus guangdongensis Wang, Yang and Grootaert, sp. nov., D. jinghongensis Wang, Yang and Grootaert, sp. nov., D. longiseta Wang, Yang and Grootaert, sp. nov. and D. ruiliensis Wang, Yang and Grootaert, sp. nov. Diaphorus tongshiensis Yang is transferred to Trigonocera. And new data on distribution are reported for nine known species. A key to the species of Diaphorus from the Chinese mainland is presented, and the distribution of the genus in the Chinese mainland is discussed.
First description of species of Chvalaea Papp & Földvári from the Neotropical Region (Diptera, Hybotidae, Ocydromiinae)
Authors: ALE-ROCHA R.
Published: March 2019

The species of Chvalaea Papp & Földvári from the Neotropical Region are described for the first time: C. amazonica, sp. n.; C. boliviana, sp. n.; C. catarinensis sp. n.; C. masneri, sp. n. and C. pulchra, sp. n. The male of this genus is described for the first time. A key to the Neotropical species of Chvalaea is also provided.
Simulium (Inaequalium) margaritatum, a new species of black fly (Diptera: Simuliidae) from the central region of Bahia State, Brazil
Authors: PEPINELLI MATEUS , Hamada NEUSA , LUZ SÉRGIO L.B.
Published: March 2019

A new species of black fly, Simulium (Inaequalium) margaritatum, is described based on the male, female, pupa, and larva. This new species was collected in small streams in the Chapada Diamantina National Park and surrounding area in the state of Bahia, Brazil.
Eriocheir ogasawaraensis Komai, a new species of mitten crab (Crustacea: Decapoda: Brachyura: Varunidae) from the Ogasawara Islands, Japan, with notes on the systematics of Eriocheir De Haan, 1835
Authors: KOMAI T. , YAMASAKI I. , KOBAYASHI S. , YAMAMOTO T. , WATANABE S.
Published: March 2019

A new mitten crab species of the genus Eriocheir De Haan, 1835, E. ogasawaraensis n. sp., is described from the Ogasawara Islands, Japan. It is morphologically most similar to E. japonica (De Haan, 1835), found on the Japanese mainland, the Ryukyu Islands, Taiwan, the Russian Far East, Korea and China, but diagnostic is the proportionately broader and dorsally flattened carapace which usually lacks the fourth anterolateral tooth, the ornamentation of the epistome, the male first gonopod and its the coloration. The biology of the new species and the different interpretations concerning the systematics of Eriocheir are briefly discussed.
A deep water Ascidia (Ascidiidae, Tunicata) from the tropical western Pacific
Authors: MONNIOT F. , MONNIOT C.
Published: March 2019

A single, solitary, free living ascidian, Ascidia alisea sp.nov., collected from a sandy substrate on the Austral Ridge (Polynesia) between 120 and 203 meters depth, is ovoid with a layer of sandy debris adhering to the tunic and has distinctive body muscles and neural area and an unusual course of its vas deferens.
Anostomoides passionis, a new fish species from rio Xingu, Brasil (Characiformes: Anostomidae)
Authors: SANTOS GERALDO M.D. , ZUANON JANSEN
Published: March 2019

We describe Anostomoides passionis, a new species of anostomid fish from rio Xingu. The species attains 306 mm SL and is distinguished from the other two congeneric species by the lateral line scale count (38–39, instead of 39–41 in A. atrianalis and 42–44 in A. laticeps) and by the color pattern: brownish-grey with two round to heart-shaped, dark blotches on the side (a larger one under the dorsal fin and another above the origin of the anal fin). Anostomoides passionis inhabits rocky stretches of the rio Xingu with moderate to high current. Stomach contents of two specimens of A. passionis caught during the low water season were composed mainly of fragments of sponges.
A redescription of Leucothoe spinicarpa (Abildgaard, 1789) based on material from the North Atlantic (Amphipoda: Leucothoidae)
Authors: CROWE STACIE E.
Published: March 2019

The identification of Leucothoe spinicarpa (Abildgaard) has presented a problem for taxonomists in recent years as it is widely regarded to be part of a species complex with cosmopolitan distribution. In an attempt to clarify the status of this species, a neotype of Leucothoe spinicarpa is herein designated and a complete redescription of the species given.
Placement of Cacoceria and phylogenetic relationships of the xylotine genera of the tribe Milesiini (Diptera, Syrphidae: Eristalinae) based on molecular characters
Authors: STÅHLS GUNILLA
Published: March 2019

The phylogenetic relationships of traditional xylotine genera of tribe Milesiini (Diptera, Syrphidae: Eristalinae) were explored using molecular character of a large fragment of the mitochondrial COI and the D2-3 region of the nuclear ribosomal 28S rRNA gene. Of particular interest was the phylogenetic placement of the enigmatic Neotropical genus Cacoceria. The ingroup included 48 taxa, and Cheilosia illustrata (Rhingiini, Eristalinae) was used as outgroup. Multiple specimens of more common taxa were sequenced for surveying levels of intraspecific variation. The combined dataset was analysed using parsimony and optimisation alignment, using the program POY. Cacoceria was resolved within the Chalcosyrphus clade. Earlier hypotheses placed the taxon in the tribe Myoleptini or Chrysogasterini, or in Xylotini without stating a closer relationship to any particular xylotine taxon. The representatives of traditional xylotine taxa were resolved as ((Hadromyia + (Brachypalpoides + Blera + Lejota) + (Xylota sg. Hovaxylota + Xylota sg. Sterphoides) + (Xylota (including Sterphus)) while Neplas and Brachypalpus were resolved in the Myoleptini albeit with very low support.
A new species of Phanaeus Macleay (Coleoptera: Scarabaeidae: Scarabaeinae: Phanaeini) from Oaxaca, Mexico
Authors: EDMONDS W. D.
Published: March 2019

Phanaeus zapotecus Edmonds, new species, is described. This species occurs in the vicinity of Sola de Vega in the Sierra Madre del Sur of Oaxaca (Mexico), where it was collected from mushrooms in pine-oak forest. It is illustrated and compared with the closely related Mexican species Phanaeus endymion Harold and Phanaeus halffterorum Edmonds.Resumen: Se describe Phanaeus zapotecus Edmonds, especie nueva, especie micetófaga que habita en los bosques pino-encino de la Sierra Madre del Sur en los alrededores de Sola de Vega, Oaxaca (México). Se compara con sus parientes, las especies mexicanas Phanaeus endymion Harold y Phanaeus halffterorum Edmonds.
Discovery of the spider family Desidae (Araneae) in South China, with description of a new species of the genus Badumna Thorell, 1890
Authors: ZHU MING-SHENG , ZHANG ZHI-SHENG , YANG ZI-ZHONG
Published: March 2019

A new species of the genus Badumna Thorell, 1890, from Yunnan Province, China is described under the name of B. tangae sp. nov. This is the first Desidae spider discovered and described from China. The new species is similar to B. insignis (L. Koch, 1872) occurring in Japan, Australia and New Zealand. But it differs from the latter by ALE largest; female with epigynal transverse ridge wide and triangular, copulatory ducts with three coils; male palpal tibia with a small, apicomedially placed, retrolateral ventral apophysis.
A new species of Tardigrada, Platicrista ramsayi sp. nov. from the páramo of Volcán Chiles, Ecuador. Zootaxa, 1166, 35–48. (ERRATUM)
Authors: MARLEY N.J.
Published: March 2019

(ERRATUM)
New species of Gnathiidae (Crustacea, Isopoda, Cymothoida) from seamounts off northern New Zealand
Authors: SVAVARSSON JÖRUNDUR
Published: March 2019

Gnathiid isopods collected from seamounts off northern New Zealand were examined. Two species of gnathiids were found, Caecognathia nieli sp. nov., and Gnathia sifae sp. nov. Caecognathia nieli sp. nov. is easily distinguished from all other known New Zealand gnathiid species in shape of the head, having an evenly rounded frontal border, and a fine bifid notch. Gnathia sifae sp. nov. is distinguished from all other New Zealand gnathiid species in having a distinct mediofrontal process on the cephalon, but no frontolateral processes. It is further clearly distinguished from the cooccurring species, Caecognathia nieli sp. nov., in having relatively larger eyes and of different shape, in the presence of lateral projections on the pereopods and in the shape of the appendix masculina.
New South American genus and species of Pteroplatini (Coleoptera, Cerambycidae, Cerambycinae)
Authors: NAPP DILMA S. , MARTINS UBIRAJARA R.
Published: March 2019

A new genus, Acabyara, and a new species, A. aruama, are described from Brazil (Amazonas, Rondonia) and Colombia (Amazonas). A key to the genera of Pteroplatini is provided.
Description of two new species of Neorhagio (Diptera, Tabanomorpha, Rhagionidae), and remarks on a controversial female character
Authors: SANTOS CHARLES M.D.
Published: March 2019

Neorhagio Lindner was known to date exclusively from its type species, from Chile. The status of the genus among the Rhagionidae is controversial, sometimes confounded with Atherimorpha White or Rhagio Fabricius. Two new species of Neorhagio, N. caligatus sp. n. and N. nagatomii sp. n., are described and illustrated based on material collected in the Reserva ‘Biosfera’ El Triunfo, Northern Mexico. The differences between Neorhagio, Atherimorpha and Rhagio are considered, and comments are made on the presence of posteroventral cercal lobes in Rhagionidae.
The thoracic sclerites of Belostoma Latreille (Hemiptera: Belostomatidae) and their usefulness for species identification
Authors: ESTEVEZ ANA L. , SCHNACK JUAN A. , DE REYES CRISTINA A.
Published: March 2019

Some thoracic sclerites, including the mesepimeron, postalar projection, wing knob, metanotum pubescence, and wing groove widening, are described and analyzed as worthy taxonomic characters for the identification of adult species of the genus Belostoma Latreille 1807. We tested the diagnostic value of these structures on specimens of B. dentatum (Mayr, 1863), B. elegans (Mayr, 1871), B. micantulum (Stål, 1860), and B. oxyurum (Dufour, 1863).
Studies on the Zoarcidae (Teleostei: Perciformes) of the southern hemisphere. IX. A new species of Pachycara from the southwestern Atlantic
Authors: ANDERSON M. E. , MINCARONE MICHAEL M.
Published: March 2019

A new species of deep-sea eelpout, Pachycara alepidotum, is described from four specimens, 199– 282 mm SL, collected in the upper bathyal zone off Rio Grande do Sul state, southern Brazil, and is the first record of the genus in the southwestern Atlantic. It is characterized by its lack of scales and ventral lateral line, few caudal vertebrae and only 1–2 rakers on the upper limb of the first gill arch. The largest specimen is an adult female.
Description of last-instar larva of Corydalus nubilus Erichson, 1848 (Megaloptera: Corydalidae) and notes on its bionomics
Authors: DE AZEVÊDO CARLOS A.S. , HAMADA NEUSA
Published: March 2019

Corydalus nubilus Erichson, 1848 (Megaloptera: Corydalidae) is a dobsonfly species with Amazonian distribution. Only its adult stage is known. In this study we provide the first description of the last-instar larva of this species and notes on the bionomics of the larvae and adults.
A checklist of the butterflies of Melanesia, Micronesia, Polynesia and some adjacent areas
Authors: TENNENT W. JOHN
Published: March 2019

A systematic checklist of the butterflies of Melanesia, Micronesia and Polynesia is presented. A significant number of previously unpublished island records were found in major museum collections in the UK, Australia and the USA. Aspects of butterfly distribution, authorship of names, and taxonomy are addressed, and sources for about 2,200 published butterfly names are incorporated in a comprehensive bibliography of Pacific butterflies. Combined with recent publications dealing with specific areas, such as Papua New Guinea, a working systematic checklist of Pacific Region butterflies is available for the first time.