bluuebunny/crossref_metadata_2025 huggingface dataset:
Un site interactif au service d’une meilleure connaissance des urgences en France : Le numérique en santé au service des territoires vécus
Authors: Kononovich Katerina , Macé Jean-Marc
Published: May 2023

La e-santé participe à la démocratisation de la connaissance de l’accès aux soins des populations. Dans une volonté de démocratie sanitaire, un site internet interactif gratuit permet à chaque usager d’interroger les différents indicateurs liés à la démographie médicale de son propre « territoire vécu »1.Ce site propose d’interroger le recours aux soins de première ligne (accès aux services des urgences) pour identifier les inadéquations de l’offre de soins aux « besoins » réels des populations. En 2015, la France métropolitaine comptait 557 services officiels d’accueil des urgences qui accueillaient plus de 17 millions primo-passages pour des soins d’urgences. Afin d’apporter un éclairage objectif à destination des usagers (citoyens, pouvoirs publics), il est nécessaire de disposer d’un territoire pertinent reflétant le plus fidèlement de la pratique spatiale des usagers, c’est-à-dire, un « territoire vécu ». Une projection à l’horizon 2025 et 2030, cible les besoins théoriques en termes de démographie médicale des médecins généralistes au niveau de ces territoires opérationnels.
Enjeux juridiques et éthiques du consentement des personnes âgées à la téléconsultation : l'exemple Normand
Authors: Cayol Amandine , Catherine Aurore , Rogue Fanny
Published: May 2023

La téléconsultation touche aujourd’hui un nombre croissant de patients, favorisée par la pandémie de Covid-19 et la volonté de lutter contre les déserts médicaux. L’utilisation de cette technologie ne dispense pas les professionnels de santé de recueillir le consentement du patient, en particulier lorsque celui-ci est âgé. S’appuyant sur un travail de recherche mené en Normandie, cet article entend présenter les enjeux, juridiques et éthiques, du recueil du consentement d’un patient âgé et préconise le recours à la téléconsultation assistée par un tiers, professionnel ou non.
Communaut’Health : Un jeu d’aménagement au service d’une stratégie intercommunale e-santé pour 2030
Authors: Le Hir Sarah , Vidal Philippe , Cuvier Alexandre
Published: May 2023

Créé dans le cadre d‘un projet de Réseau d’Intérêt Normand (RIN) intitulé EDeTeN (Enjeux du Développement de la Télémédecine en Normandie), le jeu sérieux Communaut’Health est un jeu de rôle. Il est l'aboutissement d’un travail de prospective en géographie et aménagement permettant de projeter les acteurs de la Communauté Urbaine havraise dans leur future stratégie territoriale en matière d’e-santé. Entre coopération et compétition, les joueurs, prenant le rôle de maire d’une des communes de l'intercommunalité, doivent ainsi produire une politique communautaire à l’heure du numérique permettant de lutter contre la désertification médicale et d’anticiper les effets du vieillissement de la population. Ce texte est l’occasion de revenir sur le déroulement du jeu et sur les retours observés durant les différentes parties.
La téléconsultation médicale au secours des territoires normands : quels retours d’usage ?
Authors: Le Hir Sarah
Published: May 2023

La crise du Covid-19 a eu pour conséquence de modifier le rapport des personnes à leur habiter avec une place majeure prise par le numérique dans de très nombreux domaines d’activité (professionnel, administratif, commercial, récréatif …). Elle a aussi modifié le rapport des français à la téléconsultation, passant d’expériences anecdotiques pré-covid à un recours presque obligé durant cette période : 18,4 millions d’actes ont été remboursés par l’Assurance Maladie, au cœur de la crise en 2020. Désormais et malgré la fin du confinement, la téléconsultation est envisagée par les pouvoirs publics, par certains médecins et par un certain nombre de patients, comme une solution à la désertification médicale, au vieillissement de la population et à la crise des urgences. A la croisée de la géographie de la santé et de la géographie du numérique, cette thèse envisage de répondre à la question suivante : la téléconsultation « en autonomie » ou « accompagnée » est-elle en mesure d’inverser les difficultés socio-territoriales ressenties par les territoires ? La thèse prend appui sur le terrain normand et envisage finalement l’impact de ces nouvelles solutions de soin à partir d’une analyse des retours d’usage.
QUALIDADE DE SONO E SINTOMAS DEPRESSIVOS DURANTE O PERÍODO PRÉ-MENSTRUAL - UMA REVISÃO DA BIBLIOGRAFIA
Authors: Meneses Menon Giulia , Trannin de Mello Sônia
Published: May 2023

A presente pesquisa aborda os aspectos da saúde feminina no período pré-menstrual, buscando entender qual a função dos sintomas em relação à má qualidade do sono e a dificuldade da mulher em controlar suas emoções e seus comportamentos nesse período. Tal propósito pode promover o autoconhecimento do corpo feminino e seus mais diversos fenômenos. Para tanto, a proposta tem por referência uma pesquisa realizada por meio de um levantamento bibliográfico de caráter exploratório e quantitativo. A revisão foi construída levando em consideração as etapas definidas por Botelho et al. (2011), no qual inicialmente encontrou-se 459 artigos e por final, após filtragem, 11 artigos foram utilizados para a elaboração deste estudo. Dessa forma, abordar tal assunto busca garantir o autoconhecimento e o empoderamento do corpo feminino, para que as mulheres saibam o que ocorre em seus próprios corpos, visto que, a menstruação por muito tempo fora considerada um tabu, um fenômeno “misterioso” e sem explicação.
IDENTIFICATION OF CRITICAL LACTATION STAGE FOR THE BODY COMPOSITION IN MALE OFFSPRING OF HIGH-FAT FED DAMS
Authors: Debossan Fernandes Maryana , Malta Ananda , Ferreira Barbosa Letícia , Rodrigues Raposo Scarlett , Vinícius Martins Marcos , Kian Guimarães Lopes Gabriel , Lopes Almeida Douglas , Cezar de Freitas Mathias Paulo
Published: May 2023

Each stage (early, middle and late) of lactation is a critical period during which maternalmalnutritional can negatively effects on the offspring's body development. We investigatedthe effects of a maternal high fat diet (HF) during the different stages of lactation on bodyweight of male offspring at weaning. Female Wistar rats were fed either a HF diet only duringthe first week (HF1-7 group), second week (HF7-14 group), third week (HF14-21 group) andthroughout lactation (group HF1-21) or standard diet during all lactation. Biometricparameters of dams and male offspring were evaluated. HF fed dams did not have a differencein body weight, food intake and fat pad compared with the control dams. Regarding theoffspring, a higher final body weight was observed in males from the HF7-14 and HF14-21and HF21 groups compared to the control. There was an increase in retroperitoneal andmesenteric fat in HF21 and HF14-21 compared with control groups. Higher perigonadal fatpat was only observed in HF21. Consumption of maternal HF diet throughout lactation causeshigh body weight in male offspring. Interestingly, each isolated phase also causes importantbody weight accumulation, mainly the second and third week.
GHSR MODULATION BY LEAP2 IN PERINATAL PHASES IMPACTS GLUCOSE OVERLOAD RESPONSIVENESS IN YOUNG RATS
Authors: Divino Ferreira-Junior Marcos , Valéria Naves Cavalcante Keilah , Penha Carvalho da Mota Ariel , Eduarda Ribeiro da Silva Maria , Silva Rosa Isadora , Antonio Barbosa Lima Sobrinho Jose , Henrique Xavier Carlos , Matafome Paulo , Mello Gomes Rodrigo
Published: May 2023

GHSr signaling is involved in the regulation of energy homeostasis. LEAP2, a recentlydiscovered peptide hormone, counteracts the effects of ghrelin. This study sought to evaluatethe effects of perinatal LEAP2 exposure in young rat offspring. For this, two protocols weredesigned to assess the roles of GHSr antagonism during the pregnancy and during thelactation. Sex-specific impacts on AUC and peak-responses of glucose tolerance tests werepresented. However, no differences were detected in the blood glucose of mixed meal fedanimals. In conclusion, perinatal LEAP2 exposure could impact the glucose-stimulatedinsulin secretion in young rats.
BALANÇO DAS PRODUÇÕES SOBRE AS TECNOLOGIAS DIGITAIS DA INFORMAÇÃO E DA COMUNICAÇÃO NO ENSINO DOS CONCEITOS GEOMÉTRICOS NA EDUCAÇÃO BÁSICA
Authors: Chaves Suély Colaço , Pinto Marialva Moog
Published: May 2023

As Tecnologias Digitais da Informação e Comunicação (TDIC) adquirem progressivamente mais importância no modo de vida das pessoas, na sociedade e, sobretudo, na educação. Nesse sentido, o objetivo do presente estudo é levantar as produções acadêmicas sobre a utilização das TDIC nas práticas pedagógicas para a compreensão dos conceitos da Geometria na Educação Básica. Realizou-se a busca no Repositório de Teses e Dissertações do Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT) e no Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Utilizaram-se os descritores: “TIC” AND “Matemática”, “TDIC” AND “Matemática” AND “Geometria”, “Tecnologias da Informação e comunicação” AND “Geometria”, “TIC” AND “Geometria”, “Tecnologias Digitais da Informação e Comunicação” AND “Geometria”. A seleção das produções ocorreu de acordo com a temática, o período de publicação de 2010 a 2021 e conforme a análise dos resumos. Assim, daqueles estudos encontrados inicialmente restaram apenas 09 produções correlacionadas ao objeto desta pesquisa. No decorrer deste artigo, portanto, descrever-se-ão as principais informações de cada estudo encontrado. Destaca-se, com relação aos achados, a abordagem mais empregada para o ensino de Geometria, utilizando as TDIC, são os softwares.
O CONCEITO DE CRÍTICA NA APRENDIZAGEM SIGNIFICATIVA
Authors: Silva Eliane Giselle , Gomes Paulo César , Ujiie Nájela Tavares
Published: May 2023

Em linhas gerais, teorias de aprendizagem consistem em práticas de sistematização de fatores que interferem e/ou favorecem a aprendizagem humana. O mundo contemporâneo está marcado por profundas e contínuas mudanças e essas teorias influenciam diretamente o fazer docente. A partir das discussões da teoria da Aprendizagem Significativa em Ausubel (2003), especialmente, Moreira (2010, 2017, 2019), o qual incorpora, recentemente, a noção de “crítica”; buscaremos compreender o modo como Moreira, ao argumentar sobre a necessidade da Aprendizagem Significativa enquanto atividade subversiva, articula o conceito de “crítica” a seus pressupostos teóricos. A postura crítica ressignifica a aprendizagem significativa? Quais deslocamentos são propostos para se adequar às condições de existência do sujeito na atual sociedade? Os resultados apontam que a Aprendizagem Significativa Crítica contribui para que os indivíduos entendam seu papel na sociedade sem se deixar dominar por suas rápidas transformações, processo em que o professor é elemento central na promoção da criticidade.
A DEFICIÊNCIA INTELECTUAL NA PERSPECTIVA DE PROFESSORES DA SALA DE RECURSOS MULTIFUNCIONAIS
Authors: Johnson Luanna Freitas , Yaegashi Solange Franci Raimundo , Souza Simone de , Silva Taynan Alecio da
Published: May 2023

O contingente de estudantes identificados com deficiência intelectual (DI) e encaminhados para a Sala de Recursos Multifuncionais (SRM) com vista a receber o atendimento educacional especializado é significativo. Tal quadro evidencia muitos questionamentos acerca da DI, entre eles destacamos a conceituação e caracterização da deficiência. Assim, a presente pesquisa teve como objetivo analisar as perspectivas construídas por docentes sobre esta condição. Para tanto, realizamos pesquisa de campo, por meio de questionário sociodemográfico, entrevista semiestruturada e grupo focal com oito professoras que realizam atendimento educacional especializado em SRM, da Rede Estadual de Ensino de dois municípios do Estado de Rondônia. O estudo respalda-se na Psicologia Histórico-Cultural (PHC). Os dados foram analisados por meio da técnica de análise de conteúdo. Os resultados revelam que para explicar o conceito do DI os professores recorrem, quase que exclusivamente, ao modelo médico e/ou social. Tal fato coaduna para ações pedagógicas fragmentadas que pouco contribuem para a aprendizagem e desenvolvimento do estudante com DI. Nesse sentido, a PHC possui os pressupostos teóricos que auxiliam na compreensão dos aspectos inerentes à aprendizagem e desenvolvimento da pessoa com deficiência.
DE BELLO GALLICO
Authors: Gatt Pablo , Noeme Santos Portela Ludmila
Published: May 2023

O presente artigo se debruça sobre a antiga região da Gália, que hoje compreende o território um pouco mais vasto que o atual domínio de França, uma vez que essa porção geográfica era habitada por povos célticos e constituiu uma importante província do Império Romano. Nesse sentido, nosso tempo-espaço se concentra durante o processo de pacificação efetuado por Júlio César (100-44 a.C.), e é em sua obra, Comentários Sobre a Guerra Gálica ou De Bello Gallico, que analisaremos a sociedade gaulesa em questão. Portanto, o foco desse estudo encontra-se na tentativa de esmiuçar algumas características culturais, políticas e religiosas dos gauleses, para além do estudo desse processo de pacificação. Nesse sentido, abordaremos em um primeiro momento a trajetória de Júlio César, para posteriormente estudarmos o processo de conquista e pacificação da Gália. Em seguida debatermos a respeito da cultura céltica perante a visão do mesmo, perpassando a estrutural social gaulesa, para ao final compreendermos a religiosidade céltica através dos escritos de Júlio César, especialmente por meio do Livro VI do De Bello Gallico.
A SUBSTITUIÇÃO DE VALORES NAS POLÍTICAS PARA A EDUCAÇÃO BÁSICA
Authors: Luiz Jessica , Carvalho Elma Júlia
Published: May 2023

O objetivo, neste artigo, é analisar a substituição de valores de viés econômico por valores enunciados humanitários. A análise materialista histórica dos documentos de políticas para a Educação Básica, a partir da década de 1990, torna evidente que a gênese e a função social dos valores então apregoados advêm da atividade teleologicamente orientada pelo entendimento de que a subjetividade e a objetividade compõem uma relação, pois são partes integrantes da totalidade social. Dessa perspectiva, concluímos que a adoção de valores humanitários na educação, sob o signo da reestruturação produtiva e das orientações políticas neoliberais para o enfrentamento das desigualdades econômicas, corresponde a uma estratégia para promover a coesão social e estimular a participação da sociedade civil na resolução de problemas sociais. A finalidade seria tornar os indivíduos e grupos ou a comunidade menos dependentes das políticas públicas do Estado.
BULLYING, MAUS-TRATOS E DESEMPENHO ESCOLAR
Authors: Serrer Rufo Dora , Da Silva Reginaldo Fabiane , Crochick José Leon
Published: May 2023

O objetivo deste artigo foi verificar a relação do desempenho escolar e popularidade entre pares com a violência escolar, sob as formas de maus-tratos e de bullying. A hipótese que permeia este estudo é que os alunos que apresentam pior desempenho e são considerados populares, devido ao medo que suscitam nos colegas, têm maior participação nos fenômenos de maus-tratos e de bullying. Foram aplicados instrumentos de pesquisa a 82 estudantes dos sextos anos do ensino fundamental de três escolas paulistanas: Escala de Desempenho Escolar, Escala de Popularidade e Escala de Maus-tratos e bullying. Os resultados indicam tendências de relação entre a popularidade negativa (devida ao medo e ao destaque na disciplina Educação Física) e a prática de maus-tratos, e relação invertida entre os que têm um bom desempenho nas disciplinas e a prática de maus-tratos. A importância de estar incluído na cultura, por meio da educação escolar, parece ser um bom método para o enfrentamento a esses tipos de hostilidades.
B Cell Chronic Lymphocytic Leukemia Development in Mice with Chronic Lung Exposure to Coccidioides Fungal Arthroconidia
Authors: Coyne Vanessa , Mead Heather L , Mongini Patricia K A , Barker Bridget M
Published: May 2023

Links between repeated microbial infections and B cell chronic lymphocytic leukemia (B-CLL) have been proposed but not tested directly. This study examines how prolonged exposure to a human fungal pathogen impacts B-CLL development in Eµ-hTCL1–transgenic mice. Monthly lung exposure to inactivated Coccidioides arthroconidia, agents of Valley fever, altered leukemia development in a species-specific manner, with Coccidioides posadasii hastening B-CLL diagnosis/progression in a fraction of mice and Coccidioides immitis delaying aggressive B-CLL development, despite fostering more rapid monoclonal B cell lymphocytosis. Overall survival did not differ significantly between control and C. posadasii–treated cohorts but was significantly extended in C. immitis–exposed mice. In vivo doubling time analyses of pooled B-CLL showed no difference in growth rates of early and late leukemias. However, within C. immitis–treated mice, B-CLL manifests longer doubling times, as compared with B-CLL in control or C. posadasii–treated mice, and/or evidence of clonal contraction over time. Through linear regression, positive relationships were noted between circulating levels of CD5+/B220low B cells and hematopoietic cells previously linked to B-CLL growth, albeit in a cohort-specific manner. Neutrophils were positively linked to accelerated growth in mice exposed to either Coccidioides species, but not in control mice. Conversely, only C. posadasii–exposed and control cohorts displayed positive links between CD5+/B220low B cell frequency and abundance of M2 anti-inflammatory monocytes and T cells. The current study provides evidence that chronic lung exposure to fungal arthroconidia affects B-CLL development in a manner dependent on fungal genotype. Correlative studies suggest that fungal species differences in the modulation of nonleukemic hematopoietic cells are involved.
Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway
Authors: Dong Suwei , Xiao Yanbin , Zhu Ziqiang , Ma Xiang , Peng Zhuohui , Kang Jianping , Wang Jianqiang , Wang Yunqing , Li Zhen
Published: May 2023

Metformin can enhance cancer cell chemosensitivity to anticancer drugs. IGF-1R is involved in cancer chemoresistance. The current study aimed to elucidate the role of metformin in osteosarcoma (OS) cell chemosensitivity modulation and identify its underlying mechanism in IGF-1R/miR-610/FEN1 signalling. IGF-1R, miR-610, and FEN1 were aberrantly expressed in OS and participated in apoptosis modulation; this effect was abated by metformin treatment. Luciferase reporter assays confirmed that FEN1 is a direct target of miR-610. Moreover, metformin treatment decreased IGF-1R and FEN1 but elevated miR-610 expression. Metformin sensitised OS cells to cytotoxic agents, while FEN1 overexpression partly compromised metformin’s sensitising effects. Furthermore, metformin was observed to enhance adriamycin’s effects in a murine xenograft model. Metformin enhanced OS cell sensitivity to cytotoxic agents via the IGF-1R/miR-610/FEN1 signalling axis, highlighting its potential as an adjuvant during chemotherapy.
Role of endobronchial needle aspiration during bronchoscopy in exophytic endobronchial lesions
Authors: Patil Shital , Gondhali Gajanan , Khule Shubhangi , Patil Deepak
Published: May 2023

INTRODUCTION:

Globally, lung cancer is the leading cause of new cancer diagnosis and deaths. Despite advancement in diagnostic modalities lung cancer diagnosis is often delayed due to a lack of bronchoscopy facilities and techniques. In the present study, we have analyzed the role of bronchoscopy in the diagnosis of lung cancer with special emphasis on endobronchial needle aspiration (EBNA) cytology in comparison to other conventional diagnostic techniques (CDTs) such as bronchial wash (BW) and forcep biopsy (FB).

METHODS:

Prospective, observational study screened 1280 cases with suspected lung malignancy on a clinical and radiological basis. Bronchoscopy-guided techniques such as EBNA, BW, and FB are used in exophytic endobronchial lesions (EELs) in confirming the diagnosis of lung cancer and to find additive yield over other techniques such as BW and FB. Rapid on-site evaluation analysis of all EBNA samples done in pathology laboratory allied center. Finally, histopathology proven 810 lung malignancy cases are included in this study. Statistical analysis is done using Chi-square test.

RESULTS:

In the present study, 810 diagnosed lung cancer patients between 29 and 85 years of age group predominant males 59.25% (480/810) and smokers by addiction in 63.20% (512/810) cases. Presented with cough in 82.09% (665/810), clubbing in 56.17% (455/810) cases, and mass lesion in chest radiograph in 42.22% (342/810) cases. Anatomical location is documented on the right side of tracheobronchial in 59.01% (478/810) cases during bronchoscopy. The yield of FB and FB plus bronchial wash in EEL is 89.25% (723/810) and 93.08% (754/810), respectively. The yield of EBNA, EBNA plus bronchial wash, and EBNA plus FB in EEL is 64.56% (523/810), 67.28% (545/810), and 97.65% (791/810), respectively. Total yield of all fiberoptic bronchoscopy-guided procedures (EBNA + FB + BW) in EEL is 100%. Additional yield of EBNA in EEL over other CDTs is 6.92%. Sensitivity of FB and EBNA in diagnosing lung malignancy in EEL is 89.25% and 64.56%, respectively. FB is more sensitive technique than EBNA in EEL (P < 0.00001). Sensitivity of FB plus bronchial wash in EEL is 93.08% (754/810). Sensitivity of EBNA plus bronchial wash in EEL is 67.28% (545/810). Sensitivity of EBNA plus FB in EEL is 97.65% (791/810) (P < 0.00001).

CONCLUSIONS:

EBNA has documented very crucial role in diagnosing lung cancer in comparison to other CDTs. Although FB is a more sensitive test than EBNA in EEL in diagnosing disease, we have documented EBNA has significant additive yield in proportionate number of cases. EBNA is safe, sensitive, and cytology samples can give comparable results to histopathology.
Management of Vandhyatva w.s.r. to thin endometrium through Ayurveda- A single arm open labelled pilot clinical trial
Authors: Rupareliya Jalpa Deepak , Donga Shilpa , Gandhi Abhay Jayprakash
Published: May 2023

Background:

The four essential factors of conception are Ritu (optimum period for conception), Kshetra (place of conception), Ambu (nutrition), and Beeja (healthy sperm and ovum). Kshetra denotes body as general and to be very specific, especially about the female reproductive system, it is Garbhashaya or the uterine cavity and function is Garbhadhana or conception. The endometrial factor is an important subset in infertility due to poor implantation.

Aims:

To evaluate the efficacy of Saubhagyanandana Ghrita Yonipichu (vaginal tampoon) and Jeevaniya Churna orally in the management of thin endometrium thickness and to evaluate its efficacy in the associate complains of menstrual abnormalities, i.e., irregularity of menstrual cycle, quantity, duration and pain.

Materials and methods:

It was a single-arm open labeled pilot clinical trial, a total of 15 female patients having endometrial thickness <7 mm on transvaginal sonography findings were included in the study. Each patient (n = 15) was given Saubhagyanandana Ghrita Yonipichu (10 mL for 6 days after cessation of menses, for 1 cycle) along with Jeevaniya Churna orally 10 g along with milk twice before meals for 30 days. Assessment of the study was done on Appelbaum's uterine scoring system for the reproduction (USSR) scoring pattern.

Results:

Results were analyzed by the paired' t-test for the objective parameters and Wilcoxon signed rank–sum test for the subjective parameters. A statistically highly significant difference (P < 0.001) was seen in endometrium thickness, layering, myometrial echogenicity, uterine Doppler flow, endometrial blood flow in zone 3, and total USSR score. Statistical significant difference (P < 0.05) was found in the menstrual abnormalities and a highly statistically significant difference (P < 0.001) was found in ovulation. One of the patients conceived after the treatment.

Conclusion:

Saubhagyanandana Ghrita Yonipichu (vaginal tampoon) and Jeevaniya Churna orally are effective in improving the thin endometrium.
Swasthya Assessment Scale (SAS)-Ayurveda based health assessment tool-insights on its development and validation
Authors: Ram Jaiprakash Bholanath , Yadav Babita , Ashwathykutty V. , Jameela Sophia , Ahmad Azeem , Thrigulla Saket Ram , Sharma Sakshi , Rana Rakesh K. , Singhal Richa , Rao Bhogavalli Chandrasekhara , Srikanth N. , Dhiman K. S.
Published: May 2023

Introduction:

Ayurveda has a unique way of understanding the body, health, and diseases. Various determinants, including biological, ecological, medical, psychological, sociocultural, spiritual, and metaphysical factors, which depend on each other, have their role in determining health in Ayurveda. Currently, no validated health assessment scale, based on the principles of Ayurveda is available. This article, for the first time, reports the development, validation, and reliability testing of the Swasthya assessment scale - a health assessment tool developed in Ayurveda.

Materials and methods:

A thorough literature search and expert consultations were done to draft the items encompassing the concept of health in Ayurveda. A group of experts assessed the content validity of the drafted items. Cognitive de-briefing and pretesting were performed to modify the language and the content again. Reliability testing was done with an inter-observer agreement in a sample of 183 individuals.

Results:

The content validity index for items and the scale-level content validity index (S-CVI) were calculated. S-CVI for scale was excellent, with 85% agreement. The S-CVI/universal agreement was 0.45, and S-CVI/Average was 0.95. In inter-rater reliability, the percentage agreement was 73.7%. Pearson correlation coefficient was 0.808 showing a strong correlation.

Conclusion:

Following appropriate validation, the scale can be widely used in clinical practice to assess the patient's health status, guide the treatment plans, and monitor the progress of the health. It can also be used as a sensitive tool in the research of Ayurveda to assess the changes in patients brought about by Ayurveda interventions.
Strategies for cancer therapy
Authors: Abdel-Halim Abeer H.
Published: May 2023

Cancer is still a serious health problem globally. Conventional therapies have adverse effects, which affect human life quality. Tumor microenvironment (TME), also known as surrounding stroma, has a contributory role in cancer development. Understanding the interaction between TME and cancer progression is a challenge and helps to develop new therapeutic strategies that neutralize the tracks taken by cancer cells to grow, spread, and resist therapy. Therefore, targeting TME components may be effective in improving tumor therapy. Using nanotechnology for drug delivery is of great interest, where it overcomes some obstacles such as solubility and absorption of drugs and delivering them to the appropriate place of action. The main target of nanotechnology for drug delivery is the ability to differentiate between normal and cancer cells. It can be concluded that TME is an important complementary strategy for the development of anticancer drugs. Multitargeted therapy has better efficient potential than individual therapy against cancer.
Comparison of intranasal midazolam-fentanyl with dexmedetomidine–fentanyl as pre-medication in the paediatric age group
Authors: Kaur Tripat , Kumar Parmod , Kundra Tanveer Singh , Kaur Ikjot
Published: May 2023

Background & objectives:

Intranasal midazolam-fentanyl is commonly used as pre-medication in paediatric patients, but there is a risk of respiratory depression with this combination. Dexmedetomidine is a drug that preserves respiratory function. The objective of this study was to compare the efficacy of intranasal midazolam-fentanyl and dexmedetomidine-fentanyl in paediatric patients undergoing elective surgeries.

Methods:

Hundred children in the age group of 3-8 yr of American Society of Anaesthesiologists physical status grade 1 were randomized into two groups- group A received intranasal midazolam (0.2 mg/kg)-fentanyl (2 µg/kg) and group B received intranasal dexmedetomidine (1 µg/kg)-fentanyl (2 µg/kg) 20 min before induction of general anaesthesia. Heart rate and SpO2 were monitored. Sedation score, parental separation and response to intravenous cannulation were seen after 20 min. Children were monitored for 2 h for post-operative analgesia by Oucher’s Facial Pain Scale.

Results:

Sedation scores were satisfactory in both groups, although children in group A were more sedated than in group B. Parental separation and response to intravenous cannulation were comparable in both the groups. The two groups were also haemodynamically comparable intraoperatively. Post-operative heart rate was also comparable at all-time intervals in both the groups except for heart rate at 100 and 120 min which were more in group A. Group A experienced more post-operative pain as assessed by Oucher’s Facial Pain Scale as compared to group B. Children receiving intranasal dexmedetomidine-fentanyl had better post-operative analgesia as compared to those who received intranasal midazolam-fentanyl.

Interpretation & conclusions:

Both intranasal midazolam with fentanyl and intranasal dexmedetomidine with fentanyl provided satisfactory sedation. Both groups were comparable in separation reaction and response to intravenous cannulation with better post-operative analgesia in children receiving intranasal dexmedetomidine-fentanyl.
Posterior segment involvement in systemic lupus erythematosus – A series from South India
Authors: Babu Kalpana , Nanda Satabdi , Hegde Preeti , Rao Anand P , Jois Ramesh
Published: May 2023

Purpose:

To report the spectrum of posterior segment manifestations and visual outcomes in a large series of patients with systemic lupus erythematosus (SLE).

Methods:

Retrospective study at a tertiary referral eye center in south India between 2016 and 2022.

Results:

Charts of 109 patients diagnosed to have SLE were retrieved from our medical database. Only nine cases of SLE (8.25%) had posterior segment involvement. The male: female ratio was 1:8. The mean age was 28 years. Unilaterality was the most common presentation in eight cases (88.89%). Lupus nephritis was the most common systemic presentation in five cases (55.56%). Antiphospholipid antibodies (APLA) positivity was seen in two cases (22.22%). Ocular manifestations included microangiopathy (cotton wool spots) in one case, occlusive retinal vasculitis with cotton wool spots in four cases (five eyes), optic disc edema with combined venous and arterial occlusion (one case), central retinal vein occlusion with cotton wool spots and hemorrhages (one case), macular edema (four cases), posterior scleritis with optic disc edema and exudative retinal detachment in the posterior pole (one case), and tubercular choroidal granuloma (one case). Treatment included systemic steroids, hydroxychloroquine sulfate (HCQS), and immunosuppression in all cases, blood thinners in two cases, and laser photocoagulation in four cases. HCQS-related retinal toxicity was not seen in any of the 109 cases. Ocular manifestation was the initial presentation of SLE in one case. Visual outcome was poor in three cases.

Conclusion:

Presence of posterior segment findings in cases with SLE may suggest a severe systemic disease. Early detection and aggressive treatment result in better visual outcomes. Ophthalmologists could play a vital role in guiding systemic therapy.
Deep learning–based detection of diabetic macular edema using optical coherence tomography and fundus images: A meta-analysis
Authors: Manikandan Suchetha , Raman Rajiv , Rajalakshmi Ramachandran , Tamilselvi S , Surya R Janani
Published: May 2023

Diabetic macular edema (DME) is an important cause of visual impairment in the working-age group. Deep learning methods have been developed to detect DME from two-dimensional retinal images and also from optical coherence tomography (OCT) images. The performances of these algorithms vary and often create doubt regarding their clinical utility. In resource-constrained health-care systems, these algorithms may play an important role in determining referral and treatment. The survey provides a diversified overview of macular edema detection methods, including cutting-edge research, with the objective of providing pertinent information to research groups, health-care professionals, and diabetic patients about the applications of deep learning in retinal image detection and classification process. Electronic databases such as PubMed, IEEE Explore, BioMed, and Google Scholar were searched from inception to March 31, 2022, and the reference lists of published papers were also searched. The study followed the preferred reporting items for systematic review and meta-analysis (PRISMA) reporting guidelines. Examination of various deep learning models and their exhibition regarding precision, epochs, their capacity to detect anomalies for less training data, concepts, and challenges that go deep into the applications were analyzed. A total of 53 studies were included that evaluated the performance of deep learning models in a total of 1,414,169°CT volumes, B-scans, patients, and 472,328 fundus images. The overall area under the receiver operating characteristic curve (AUROC) was 0.9727. The overall sensitivity for detecting DME using OCT images was 96% (95% confidence interval [CI]: 0.94–0.98). The overall sensitivity for detecting DME using fundus images was 94% (95% CI: 0.90–0.96).
Impact of preoperative posterior segment evaluation on surgical intervention in camp patients: A retrospective analysis
Authors: Jain Priti , Ahuja Nisha
Published: May 2023

Purpose:

To retrospectively study impact of preoperative posterior segment evaluation on surgical intervention in camp patients recruited for cataract surgery in Gujarat India.

Methods:

Retrospective analysis of six months data collected from hospital electronic medical record (EMR) system of 9820 admitted patients recruited from screening camp for cataract surgery from 1/10/2019 to 31/3/2020 in Tertiary Eye Hospital in Gujarat, India, has been done. Comprehensive clinical evaluation, of both anterior and posterior segment which included detailed history; best corrected visual acuity (BCVA); intraocular pressure measurement with non-contact tonometer (NCT) and when required with Goldman applanation tonometer; slit lamp examination; and fundus examination with + 90 diopter lens as well as indirect ophthalmoscope as and when indicated. In case there was no view of retina, a B-scan ultrasound was done to rule out any posterior segment pathology. Immediate surgical intervention done was assessed and results analyzed in percentage.

Results:

Cataract surgery was advised for 8390 patients (85.43%). Surgical intervention for management of glaucoma was done for 68 patients (0.692%). Retina intervention was done for 86 patients. Posterior segment evaluation changed immediate surgical plane of management for 154 (1.57%) patients.

Conclusion:

Comprehensive clinical evaluation is economical and should be mandatory especially in community services as comorbid conditions like glaucoma, diabetic retinopathy, retinal vein occlusion, and other varied posterior segment diseases contribute significantly to visual disability in elderly age group. It is difficult to follow these patients later if manageable comorbidity is not informed about and if indicated dealt simultaneously for visual rehabilitation of patient.
Five-Year Follow-up in Patients with Transobturator Tape – A Retrospective Observational Study
Authors: Verneker Ruchika A. , Mishra Vineet , Tutwala Nimish , Lamba Sunita
Published: May 2023

Background:

Stress urinary incontinence (SUI) could be due to urethral hypermobility due to the weakening of the pelvic floor muscles which support the urethra and bladder or the intrinsic sphincter deficiency. The mid-urethral tape acts as an anchored pubo-urethral neo-ligament thus increasing the level of mid-urethral support. The purpose of this study is to evaluate the safety and efficacy of transobturator tape (TOT) for SUI at 5 years of follow-up.

Materials and Methods:

This was a retrospective observational single-arm study of 40 patients. Ten patients were lost to follow-up; hence, only 30 patients were included in the study. Patients who underwent TOT from 2010 to 2012 were followed up till December 2017. Patients were evaluated for early and late postoperative complications and efficacy of the tape at 5 years.

Results:

The mean age of the patients with SUI was 48.07 (standard deviation ± 9.38). About 76.66% (n = 23) of patients had only pure stress incontinence, whereas 23.3% of patients (n = 7) had mixed urinary incontinence (MUI). The cure rate in our study was 93.33% at 5 years. Out of the seven patients with MUI, urge incontinence was cured in 71.42% (n = 5). De novo urgency was observed in 6.6% (n = 2). No major complications such as bladder and bowel perforation, vascular hemorrhage, or mesh erosion were seen. Patient satisfaction was graded as excellent in 46.66% (n = 14), good in 30% (n = 9), and poor in 23% (n = 7).

Conclusion:

TOT for stress incontinence has a high cure rate and very good efficacy at 5 years. No major complications are seen when the procedure is performed by expert hands.
Salivary Menopausal Markers and Oral Health Status – A Hidden Hook Up
Authors: Soundarya B , Massillamani F , Kailasam S , Jayashree G , Narmadha N , Sornaa N
Published: May 2023

Aim and Objectives:

The aim of our study was to evaluate salivary estradiol and salivary calcium in postmenopausal women with varying degrees of oral dryness. The primary objective was to establish the interrelationship between salivary parameters and oral health status among menopausal women and compare the same with premenopausal women and normal controls.

Materials and Methods:

The study included 60 women Group I consisted of healthy menstruating women between 25 and 34 years of age. In Group II premenopausal women between 35 and 45 years of age were present and Group III consisted of menopausal women between 45 and 60 years of age. Unstimulated saliva was collected from the participants and estradiol analysis was done using ELISA method and calcium analysis was done using Arsenazo III reaction using colorimetric method. The oral health status in these patients was determined by using xerostomia score, Russell's periodontal score, and oral hygiene index. The values obtained were subjected to statistical analysis and the results were derived.

Results:

On oral examination, most of them had poor oral hygiene, periodontal disease, and moderate to severe levels of xerostomia. Salivary estradiol levels were low and salivary calcium levels were high among postmenopausal women and as salivary estradiol levels decreased there was an increase in xerostomia scores and salivary calcium. And also as salivary calcium levels increased the periodontal disease scores increased. All parameters were within normal limits among healthy menstruating women.

Conclusion:

Saliva can be a preferred medium and an emerging alternative for serum to estimate estradiol and calcium levels. As a dentist, we have to educate them about the oral changes they will experience during menopause and emphasize its strong association between low estradiol levels. Oral hygiene instructions should be given for the maintenance of healthy periodontium. Menopausal women who experience severe postmenopausal symptoms can be identified and the dentist and gynecologist can work hand in hand to treat the symptoms of these women.
Pupillary dynamics and accommodative response in mild traumatic brain injury
Authors: Dutta Pritam , Atiya Ayisha , Vittal Smita , Ambika S. , Hussaindeen Jameel Rizwana
Published: May 2023

PURPOSE:

To measure the pupillary dynamics and accommodative response in individuals with mild traumatic brain injury (mTBI) as compared to age-matched controls.

MATERIALS AND METHODS:

This prospective comparative study was carried out at the neuro-optometry clinic of a tertiary eye care hospital. Sixty-three subjects with a history of mTBI and ninety age-matched controls were enrolled in this study. Subjects in the age range of 18–35 years were included in the study. A comprehensive neuro-optometric assessment was performed followed by pupillary dynamics and accommodation response measurements using NeurOptics® pupillary light reflex™-3000 and Grand-Seiko WAM-5500 binocular accommodation auto ref/keratometer | shigiya machinery works LTD.

RESULTS:

A statistically significant difference was noticed for constriction percentage (%): 32.73 ± 9.20 versus 39.93 ± 7.36 (P < 0.001), average constriction velocity (mm/s): 2.24 ± 0.85 versus 2.62 ± 0.68 (P = 0.002), maximum constriction velocity (mm/s): 3.82 ± 1.33 versus 4.42 ± 0.93 (P = 0.004) and T75 (recovery period to 75% of the baseline pupillary diameter in sec): 1.38 ± 0.36 versus 2.0 ± 0.82 (P < 0.001) in mTBI compared to age-matched controls. A statistically significant difference was noted for accommodative response (in D) as well as in the sample as compared to age-matched controls: −1.12 ± 0.64 versus − 1.39 ± 0.47 (P < 0.001).

CONCLUSION:

Pupillary constriction velocities and accommodative response are significantly affected in mTBI. These findings have important clinical implications in being able to understand the visual symptoms following an mTBI.
Nonsurgical management of upper eyelid retraction in thyroid eye disease
Authors: Young Stephanie Ming , Kim Yoon-Duck , Woo Kyung In
Published: May 2023

Upper eyelid retraction (UER) is the most common sign of thyroid eye disease (TED) and may result in lagophthalmos and exposure keratopathy. Measures to address UER are varied and include conservative treatment, surgical intervention, and injections of botulinum toxin, hyaluronic acid (HA) filler, and triamcinolone acetonide (TA). Our article will discuss the various nonsurgical aspects of managing TED-related UER, focusing on the injections of botulinum toxin, HA filler, and TA to the upper eyelid, which have all been reported to be effective in improving UER in both active and inactive states of TED. Individual response may vary, and repeated injections may be necessary.
Landslide susceptibility zonation using geospatial techniques and Analytical Hierarchy Process: A case study in Muong Lay town and its vicinity
Authors: Nguyen Liem Duy , Nguyen Luc Manh , Duong Thanh Van , Tran Anh Ngoc Thi , Phung Anh Ngoc Thi ,   Nong Lam University, Ho Chi Minh City, Vietnam  Institute of Geophysics, Hanoi, Vietnam
Published: May 2023

This study demonstrates an integrated approach of remote sensing, geographic information system (GIS), and Analytical Hierarchy Process (AHP) method to create a landslide susceptibility map for Muong Lay town and its vicinity in Northern midland and mountainous of Vietnam. Nine landslide-related factors, including petrological composition, active fault density, slope, drainage density, the difference in height per unit area, land cover, soil texture, maximum daily rainfall, and earthquake density were created using ground or remotely sensed data in a GIS environment. Weight for each factor was assigned using AHP depending on its relative importance in landslide occurrence in the study area through literature review. The landslide susceptibility map was generated using a weighted linear combination method in GIS and categorized into five susceptible classes namely, very low, low, moderate, high, and very high using quantile classification. The results revealed that 29% of the study area is at very low susceptibility, 24% at low susceptibility, 21% of moderate susceptibility, 15% of high susceptibility, and 11% of very high susceptibility area coverage. The effectiveness of these results was checked by computing the area under Receiver Operating Characteristic curve (AUC) which showed a satisfactory result of 63.3%. Most of the recorded landslide events were located in high and very high susceptibility areas. These findings could be useful to planners and decision-makers in land use planning and slope management to prevent or reduce future landslides.
Geotechnical zoning in Hai Duong province for construction planning
Authors: Do Thang Hong , Nguyen Phong Van ,   DAVICO. JSC, Hai Duong, Vietnam  Hanoi University of Mining and Geology, Hanoi, Vietnam
Published: May 2023

Information on geology and engineering plays an important role in construction activities, forecasting adverse problems, and choosing the foundation solutions. The management and use of this information on the basis of zoning geological conditions will contribute to ensure the sustainability in economic exploitation of the territory in general and in construction development in particular. This paper presents the results of analysis, evaluation, and systematization of geological, tectonic, geomorphological, hydrogeological, and engineering geological data in Hai Duong province from the point of view of engineering geology. In particular, the geological conditions for construction are evaluated on the basis of classification of soil and rock of F.P Xavarenski and standard TCVN 9362-2012. Accordingly, soil and rock in the study area are divided into 5 groups: hard rock (I), semi-hard rock (II), cohesiveless soil (III), cohesive soil (IV) and soft soil (V) and then they are classified according to construction properties. Applying the partitioning method of I.V. Popov, the geotechnical conditions of the study area are divided into 3 zones: I, II, III and 3 sub-zones (III.a, III.b, III.c). On that basis, engineering geology problems in each zone and sub-zone are analyzed and evaluated as the basis for planning, serving for digitization and integration relating to digitized maps.
A new design on a multi - purpose trolley chair to support patients’ care process
Authors: Nguyen Linh Khac , Doan Giap Van , Pham Tien Van , Le Thang Hong Thi ,   Hanoi University of Mining and Geology, Hanoi, Vietnam
Published: May 2023

Wheelchairs, trolley chairs, and potty chairs are essential for people with disabilities, patients, and elderly. These forms of equipments are specially designed to support specific needs of their users, such as moving, bathing, and resting, etc. Since the function of equipment is limitted, patients with multiple problems may need more than one single equipment to be properly supported, which make the caring processes more complicated because patients have to be transferred between equipment, also increase the cost on equipment. This paper presents a new design on a multi-purpose trolley chair to better support patient’s life. Multi-purpose trolley chair can be used as a lifting and transfering equipment, or supporting devices for moving, bathing of patients and elderly. The seat on multi-purpose trolley chair is seprated into 2 pieces and can be adjusted by a smart-locking system, the chair back can be flexibility rotated back and front, and the whole seating set is installed on a mechanic lifting mechanism to better fit and comfort patients with different sitting modes to satisfies required medical treatment positions or easier moving, Moreover, this device can be placed in the bedroom as a regular toilet seat, helping patients avoid having to travel far when they are alone. Combining with the use of computational software for structural analysis, such as NX and SAP2000, to optimize the design, the calculation and design process can be done quickly with the aim of reducing the weight of the vehicle while ensuring durability, rigidity, and safety during operation. Conducting this research is an initial basis to quickly bring the versatile patient care wheelchair product into practice.