bluuebunny/crossref_metadata_2025 huggingface dataset:
Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia
Authors: Finch Emily R. , Smith Colton A. , Yang Wenjian , Liu Yiwei , Kornegay Nancy M. , Panetta John C. , Crews Kristine R. , Molinelli Alejandro R. , Cheng Cheng , Pei Deqing , Ramsey Laura B. , Karol Seth E. , Inaba Hiroto , Sandlund John T. , Metzger Monika , Evans William E. , Jeha Sima , Pui Ching‐Hon , Relling Mary V.
Published: October 2019

Background

Glucocorticoids and asparaginase, used to treat acute lymphoblastic leukemia (ALL), can cause hypertriglyceridemia. We compared triglyceride levels, risk factors, and associated toxicities in two ALL trials at St. Jude Children's Research Hospital with identical glucocorticoid regimens, but different asparaginase formulations. In Total XV (TXV), native Escherichia coli l‐asparaginase was front‐line therapy versus the pegylated formulation (PEG‐asparaginase) in Total XVI (TXVI).

Procedure

Patients enrolled on TXV (n = 498) and TXVI (n = 598) were assigned to low‐risk (LR) or standard/high‐risk (SHR) treatment arms (ClinicalTrials.gov identifiers: NCT00137111 and NCT00549848). Triglycerides were measured four times and were evaluable in 925 patients (TXV: n = 362; TXVI: n = 563). The genetic contribution was assessed using a triglyceride polygenic risk score (triglyceride‐PRS). Osteonecrosis, thrombosis, and pancreatitis were prospectively graded.

Results

The largest increase in triglycerides occurred in TXVI SHR patients treated with dexamethasone and PEG‐asparaginase (4.5‐fold increase; P <1 × 10−15). SHR patients treated with PEG‐asparaginase (TXVI) had more severe hypertriglyceridemia (>1000 mg/dL) compared to native l‐asparaginase (TXV): 10.5% versus 5.5%, respectively (P = .007). At week 7, triglycerides did not increase with dexamethasone treatment alone (LR patients) but did increase with dexamethasone plus asparaginase (SHR patients). The variability in triglycerides explained by the triglyceride‐PRS was highest at baseline and declined with therapy. Hypertriglyceridemia was associated with osteonecrosis (P = .0006) and thrombosis (P = .005), but not pancreatitis (P = .4).

Conclusion

Triglycerides were affected more by PEG‐asparaginase than native l‐asparaginase, by asparaginase more than dexamethasone, and by drug effects more than genetics. It is not clear whether triglycerides contribute to thrombosis and osteonecrosis or are biomarkers of the toxicities.
Perspective: present pesticide discovery paradigms promote the evolution of resistance – learn from nature and prioritize multi‐target site inhibitor design
Authors: Gressel Jonathan
Published: October 2019

For many years, the emphasis of industry discovery programs has been on finding new target sites of pesticides and finding pesticides that inhibit single targets. There had been an emphasis on genomics in finding single targets for potential pesticides. There is also the claim that registration of single target inhibiting pesticides is simpler if the mode of action is known. Conversely, if one looks at the evolution of resistance from an epidemiological perspective to ascertain which pesticides have been the most recalcitrant to evolutionary forces, it is those that have multiple target sites of action. Non‐target‐site resistances can evolve to multi‐target‐site inhibitors, but these resistances can often be overcome by structural modification of the pesticide. Industry has looked at pest‐toxic natural products as pesticide leads, but seems to have abandoned those where they can find no single target of action. Perhaps nature has been intelligent and evolved many natural products that are synergistic multi‐target‐site inhibitors, and that is why natural compounds have been active for millennia? We should be learning from nature while combining new chemistry technologies with vast accrued databases and computer aided design allowing fragment‐based discovery and scaffold hopping to produce multi‐target site inhibitors instead of single target pesticides. © 2019 Society of Chemical Industry
Resistance to clethodim in Italian ryegrass (Lolium perenne ssp. multiflorum) from Mississippi and North Carolina
Authors: Nandula Vijay K , Giacomini Darci A , Lawrence Benjamin H , Molin William T , Bond Jason A
Published: October 2019

BACKGROUND

Clethodim, an acetyl‐CoA carboxylase (ACCase)‐inhibiting herbicide, is one of the few postemergence chemical control options available to growers of Mississippi to manage glyphosate and/or other herbicide resistant Italian ryegrass populations. Recently, clethodim failed to adequately control Italian ryegrass populations across Mississippi. A sethoxydim, also an ACCase inhibitor, ‐resistant Italian ryegrass population from North Carolina was cross‐resistant to clethodim. This research characterized the magnitude and mechanisms of clethodim resistance in the Mississippi and North Carolina Italian ryegrass populations via whole‐plant herbicide dose response, cross resistance, and metabolism studies, and molecular analysis.

RESULTS

Two clethodim‐resistant biotypes from Mississippi, MS24 and MS37, were 10‐ and 4‐fold resistant, respectively, relative to a susceptible (SUS1) biotype. A North Carolina biotype, NC21, was 40‐fold resistant to clethodim compared to SUS1. Two additional biotypes from North Carolina, NC22 and NC 23, recorded shoot dry weight reduction of only 17–30% of nontreated at the highest clethodim dose of 2.17 kg ha−1, (8×). The NC22 biotype was cross‐resistant to sethoxydim, fluazifop, quizalofop, and pinoxaden. Metabolic inhibitors such as piperonyl butoxide and 4‐chloro‐7‐nitrobenzofurazan did not affect resistance of MS37, MS51, and NC22 biotypes to fenoxaprop, clethodim, or pinoxaden. The MS37 biotype had three target site mutations, I2041N, C2088R, and G2096A. Another clethodim‐resistant biotype from Mississippi, MS51, had only the C2088R substitution. The NC22 and NC23 biotypes had I1781L, I2041N, and D2078G replacements.

CONCLUSION

This study shows that the mechanism of resistance to clethodim in Italian ryegrass from Mississippi and North Carolina is due to target site modifications in the ACCase gene leading to broad cross‐resistance to other ACCase‐inhibiting herbicides. Published 2019. This article is a U.S. Government work and is in the public domain in the USA.
Synthesis, characterization, and evaluation of novel cell‐penetrating peptides based on TD‐34
Authors: Tian Tian , Zhang Xiaodong , Sun Yuming , Li Xiaohui , Wang Qing
Published: October 2019

In this study, six N‐1, N‐2, or N‐11 derivatives of TD‐34 (a cationic cyclic cell‐penetrating peptide [CPP], ACSSKKSKHCG) were designed and synthesized including both linear peptides and cyclic peptides, such as DL‐1 (KWSSKKSKHCG), DLCC‐1 (cyclopeptide, KWSSKKSKHCG), DL‐2 (KWSSKKSKHCG‐NH2), DLCC‐2 (cyclopeptide, KWSSKKSKHCG‐NH2), DL‐3 (RWSSKKSKHCG), and DLCC‐3 (cyclopeptide, RWSSKKSKHCG). The cyclic peptides were synthesized by disulfide bound linkages formed by N‐2 and N‐10 cysteine. In vitro penetration experiment was conducted to investigate the transdermal enhancement ability of these derivatives, using triptolide (TP) as model drug. The results display that at the presence of DLCC‐2, the accumulative penetration amount of TP increased 1.71‐fold (P < .05) within 12 hours, displaying better transdermal enhancing ability than TD‐34. Meanwhile, DL‐3 and DLCC‐3 slightly decreased the transdermal delivery of TP, and the presence of DL‐1 and DLCC‐1 shows no obvious effect. In order to clarify the factors on the transdermal ability of peptides, the solubility of TP in phosphate buffer saline (PBS) at the presence of different peptides and the mechanism of transdermal delivery of CPPs was investigated. The result shows that most of these peptides have no significant effect on the solubility of TP except DLCC‐3 (the solubility of TP slightly increased). And in order to investigate transdermal absorption route of DLCC‐2, polyarginine linked to rhodamine b (Rh b) derivative is used. The result proved that the transdermal route of polyarginine is via hair follicle, which may change the transdermal route of its cargo molecule (TP). Our group previously proved that polyarginine and TD‐34 have similar transdermal enhancing mechanism (changing the transdermal route of their cargo molecule); it is reasonably speculated that the transdermal route of DLCC‐2 is the same as polyarginine and then changes the transdermal absorption route of TP. Furthermore, such results have laid a solid foundation for further investigation of CPPs and paved a way for both designing and synthesizing of new drug delivery system for therapy molecules.
Impact of model resolution on the representation of the wind speed field: An example from the United Kingdom
Authors: De Benedetti Marc , Moore G. W. K.
Published: October 2019

The United Kingdom (UK) is experiencing rapid growth in wind farm development, primarily in the south as well as in offshore regions. As such, reliable long‐term wind statistics are integral in planning future development. Given the scarcity of in situ data, atmospheric reanalyses are beginning to be used for this purpose. However, most reanalyses have resolutions of ∼50 km or lower – scales too coarse to capture many topographic and coastal effects. To address this, dynamical downscaling has been used to obtain higher‐resolution data. However, it is unclear how the downscaling process impacts the temporal and spatial representation of the wind field. Here a set of reanalysis and analysis datasets with a common lineage and with horizontal resolutions ranging from ∼75 to ∼9 km are used to investigate the impact of model resolution on the representation of the spatial and temporal variability in the wind field in the UK. To assess this impact, the decorrelation length and temporal scale – DCLS and DCTS, respectively – are used to characterize spatial and temporal variability. The results can be classified into two categories – resolution‐dependent and resolution‐independent features. Resolution‐dependent results suggest that even resolutions of ∼30 km do not capture the wind field's variability, especially in coastal and mountainous regions. However, resolution‐independent results suggest that there are regions, such as central Ireland, over the oceans, and southeastern England, where the 30 km resolution captures the wind fields' variability. Results also support the historic choice of wind farm development in the UK, namely, the southern/southwestern tip of England as well as off the southern shore.
Building Blocks for Quantum Network Based on Group‐IV Split‐Vacancy Centers in Diamond
Authors: Chen Disheng , Zheludev Nikolay , Gao Wei‐bo
Published: October 2019

One ultimate goal of quantum information processing is to construct a quantum network for direct sharing of quantum information between distant parties based on stationary qubits for information storage and flying qubits for information transmission. This requires long‐lived quantum memories, efficient light–matter interface, and deterministic quantum gate operations. Among matter qubits, the electron spin of nitrogen vacancy center in diamond is an appealing option for its long coherence time at room temperature, deterministic microwave control, and optical preparation and readout of the qubit. However, its poor optical properties, including weak zero‐phonon‐line emission and large spectral diffusion, limit its potential for large‐scale deployment in quantum nodes. This has motivated the investigation for alternative quantum emitters that combine long‐time memory and coherent optical properties together. The emerging group‐IV split‐vacancy color centers in diamond, such as silicon‐vacancy, germanium‐vacancy, tin‐vacancy, and lead‐vacancy centers, are promising candidates of this ongoing exploration. These quantum emitters simultaneously possess microsecond spin coherence time and optically bright transitions with narrow linewidths. This review reports recent efforts on extending the spin coherence time of these color centers via temperature, strain, and charge control, which paves the road towards constructing solid‐based matter–photon interface for quantum network applications.
Game Face expressions and performance on competitive tasks
Authors: Richesin Matthew T. , Oliver Michael D. , Baldwin Debora R. , Wicks Lahai A.M.
Published: October 2019

Facial expressions influence both affective and cardiovascular responses to stress. However, previous research focuses primarily on positive expressions and is limited regarding additional facial expressions utilized on a day‐to‐day basis. This study examined an expression that is colloquially called a “Game Face”: which refers to a serious, focused or determined facial expression. The current study examined whether Game Face expressions would influence psychophysiological response (e.g., heart rate and skin conductance) and performance. In an investigation of physical performance (Study 1), participants (N = 62) were asked to complete the cold‐pressor task. Study 2 tested cognitive performance utilizing a puzzle task. Participants (N = 62) were divided into two groups and were asked to complete a puzzle. In both studies, one group was asked to make a Game Face, and the other was given no instruction related to facial expression. Results show no significant differences in performance on the physical task. In terms of cognitive performance, results reveal significantly better performance in the Game Face group. Additionally, assessments of skin conductance show that participants, who employed the Game Face during the cognitive task, displayed significant decreases from baseline following the puzzle manipulation. These results are promising regarding performance on a cognitive task and sympathetic nervous system activation, in concert with making a Game Face.
Optoacoustic imaging in gastroenterology
Authors: Klett Daniel M. , Waldner Maximilian J.
Published: October 2019

Imaging modalities are crucial for diagnosis and monitoring of various gastroenterological diseases. To overcome limitations in established imaging methods, to improve outcome and reduce invasive procedures alternate modalities are needed. Optoacoustic imaging (OAI), an emerging method in both preclinical and translational settings, offers possible solutions to currently existing limitations. By enhancing tissue contrast and visualization of chromophoric molecules, OAI can provide detailed information about tumour architecture, perfusion and inflammation—an urgently needed ability in gastroenterology. Whilst some gastroenterological applications like noninvasive monitoring of inflammatory bowel disease were already successfully translated into clinical settings, others still await their verification in human studies. With ongoing development of the technique, more translational applications can be expected to follow. This review is focused on summarizing previous and current preclinical and translational applications of OAI in gastroenterology, their benefits compared to established methods as well as limitations and possible future implementations of the technique in gastroenterological settings.
Contrast enhancement by intensity preservation‐based dynamic histogram equalization for electrowetting display
Authors: Lin Shanling , Lin Zhixian , Guo Tailiang , Tang Biao
Published: October 2019

Due to the phenomenon of contact angle saturation and charge trapping, contrast of the electrowetting display will be decreased, and the details of the image will be lost. A histogram equalization algorithm is commonly used to improve the image contrast enhancement. Therefore, in order to improve the display quality of the electrowetting display, this article proposes an extension of dynamic histogram equalization (DHE) techniques, called intensity preservation‐based dynamic histogram equalization (IPDHE). Initially, the proposed IPDHE technique separates the histogram into four subhistograms based on intensity preservation. Then, the resultant subhistograms are reshaped by the nonzero bins as the amount of emphasis given on total pixels. Mathematically, the intensity preservation measure of each subhistogram stands for the density and boosted level of the subhistogram. Finally, each subhistogram is equalized. Simulation results show that, for the dataset of test images, the proposed algorithm successfully enhances the contrast of images while preserving the maximum average information content (entropy), presents more image details, and applies to the electrowetting display. © 2019 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Spontaneous symmetry breaking in fermionic random matrix model
Authors: Aref’eva Irina , Volovich Igor
Published: October 2019

Abstract

A fermionic random matrix model, which is a 0-dimensional version of the SYK model with replicas, is considered. The replica-off-diagonal correlation functions vanish at finite N, but we show that they do not vanish in the large N limit due to spontaneous symmetry breaking. We use the Bogoliubov quasi-averages approach to studying phase transitions. The consideration may be relevant to the study of the problem of existence of the spin glass phase in fermionic models.
Correlations between microsatellite instability and the biological behaviour of tumours
Authors: Yang Guang , Zheng Ru-yi , Jin Zai-shun
Published: October 2019

Purpose

Microsatellites are widely distributed repetitive DNA motifs, accounting for approximately 3% of the genome. Due to mismatch repair system deficiency, insertion or deletion of repetitive units often occurs, leading to microsatellite instability. In this review, we aimed to explore the relationship between MSI and biological behaviour of colorectal carcinoma, gastric carcinoma, lymphoma/leukaemia and endometrial carcinoma, as well as the application of frameshift peptide vaccines in cancer therapy.

Methods

The relevant literature from PubMed and Baidu Xueshu were reviewed in this article. The ClinicalTrials.gov database was searched for clinical trials related to the specific topic.

Results

Microsatellite instability is divided into three subtypes: high-level, low-level microsatellite instability, and stable microsatellites. The majority of tumour patients with high-level microsatellite instability often show a better efficacy and prognosis than those with low-level microsatellite instability or stable microsatellites. In coding regions, especially for genes involved in tumourigenesis, microsatellite instability often results in inactivation of proteins and contributes to tumourigenesis. Moreover, the occurrence of microsatellite instability in coding regions can also cause the generation of frameshift peptides that are thought to be unknown and novel to the individual immune system. Thus, these frameshift peptides have the potential to be biomarkers to raise tumour-specific immune responses.

Conclusion

MSI has the potential to become a key predictor for evaluating the degree of malignancy, efficacy and prognosis of tumours. Clinically, MSI patterns will provide more valuable information for clinicians to create optimal individualized treatment strategies based on frameshift peptides vaccines.
Mass spectrometry transanal minimally invasive surgery (MS-TAMIS) to promote organ preservation in rectal cancer
Authors: Mason Sam , Manoli Eftychios , Poynter Liam , Alexander James , Paizs Petra , Adebesin Afeez , Goldin Robert , Darzi Ara , Takats Zoltan , Kinross James
Published: October 2019

Background

Transanal minimally invasive surgery (TAMIS) is deployed for organ preservation in early rectal cancer and significant rectal polyps. Rapid evaporative ionisation mass spectrometry (REIMS) provides biochemical tissue analysis, which could be applied intraoperatively to give real-time tissue feedback to the surgeon and decrease the risk of an involved margin. However, the accuracy and feasibility of this approach have not been established.

Methods

In this prospective observational study, patients undergoing resection of rectal adenomas or carcinomas were recruited. An electrosurgical handpiece analysed tissues ex vivo using diathermy, with the aerosol aspirated into a Xevo G2-S ToF mass spectrometer. The relative abundance of lipids underwent predictive statistical modelling and leave-one-patient-out cross-validation. The outcomes of interest were the ability of REIMS to differentiate normal, adenomatous and cancerous tissue, or any disease subtype from normal. REIMS was coupled with TAMIS for in vivo sampling, assessing the accuracy of tissue recognition and distinguishing bowel wall layers.

Results

Forty-seven patients were included, yielding 266 spectra (121 normal, 109 tumour and 36 adenoma). REIMS differentiates normal, adenomatous and cancerous rectal tissues with 86.8% accuracy, and normal and adenomatous tissue with 92.4% accuracy and 91.4% accuracy when differentiating disease from normal. We have performed the first five in-man mass spectrometry augmented TAMIS (MS-TAMIS). In real time, MS-TAMIS can differentiate rectal mucosa and submucosa based on their relative abundance of triglycerides and glycerophospholipids. The ex vivo accuracy distinguishing diseased and normal tissues is maintained in vivo at 90%, with negative predictive value of 95%. The system identified a deep and lateral involved tumour margin during TAMIS.

Conclusions

REIMS distinguishes rectal tissue types based on underlying lipid biology, and this can be translated in vivo by coupling it to TAMIS. There is a role for this technology in improving the efficacy of resection of early rectal cancers.
Correction to: Incorporating climate change into invasive species management: insights from managers
Authors: Beaury Evelyn M. , Fusco Emily J. , Jackson Michelle R. , Laginhas Brittany B. , Morelli Toni Lyn , Allen Jenica M. , Pasquarella Valerie J. , Bradley Bethany A.
Published: October 2019

The article Incorporating climate change into invasive species management: insights from managers, written by Evelyn M. Beaury
Adaptive electronic differential control of vehicle by torque balance
Authors: Tian Hong , Zhu Weiguo , Wang Sharon
Published: October 2019

Current adaptive torque balancing control of electric wheel-driven vehicle has shortcomings in electronic differential control of drive motor by using rotation speed mode. In order to solve this problem, an adaptive electronic differential control method of electric wheel-driven vehicle is proposed in this paper by torque balance. Firstly, by starting from the kinematics and dynamics of vehicle steering, the speed and force of each drived wheel in the steering are analyzed to explain the auxiliary role of electronic differential control to adaptive torque balancing, as well as influence of steering radius in vehicle. Then, electronic differential distribution by torque of wheel is used to control the abnormal jump interference and calculate the optimal combination of parameters in electronic differential control system. Finally, based on the optimal combination of these parameters, an adaptive electronic differential control of electric wheel-driven vehicle by torque balance is realized with fuzzy control in active and the reactive power. Experimental results show that the proposed method suppresses the abnormal jump interference factors of electronic differential control, as well as realizes the differential functions in control system. It has far-reaching significance by provideing a basic guarantee to realize adaptive electronic differential control system in electronic wheel-driven vehicle.
Nonlinear dynamic analysis of low viscosity fluid-lubricated tilting-pad journal bearing for different design parameters
Authors: Jin Yingze , Chen Fei , Xu Jimin , Yuan Xiaoyang
Published: October 2019

To reveal nonlinear dynamic rules of low viscosity fluid-lubricated tilting-pad journal bearings (TPJBs), the effects of design parameters on journal center orbits and dynamic minimum film thicknesses of water-lubricated TPJBs with and without static loads are investigated. The hydrodynamic bearing force used in the nonlinear dynamic analysis is an approximate analytical solution including the turbulence effect. The results reveal the methods for vibration suppression and load capacity improvement and give an optimal pivot offset and clearance ratio that can maximize the minimum film thickness. The results also show that four-pad TPJBs with loads between pads are preferred due to good dynamic performance and load capacity. This study would provide some guidance for nonlinear design of low viscosity fluid-lubricated TPJBs under dynamic loads.
Validity of Amontons’ law for run-in short-cut aramid fiber reinforced elastomers: The effect of epoxy coated fibers
Authors: Khafidh M. , Schipper D. J. , Masen M. A. , Vleugels N. , Dierkes W. K. , Noordermeer J. W. M.
Published: October 2019

Friction between two contacting surfaces is studied extensively. One of the known friction theories is Amontons’ law which states that the friction force is proportional to the normal force. However, Amontons’ law has been found to be invalid for elastomers. In the present study, the validity of Amontons’ law for short-cut aramid fiber reinforced elastomers is studied. Two types of fillers are used to reinforce the elastomers, namely highly dispersible silica and short-cut aramid fibers. Short-cut aramid fibers with two different surface treatments are used, namely non-reactive fibers with standard oily finish (SF-fibers) and fibers treated with an epoxy coating (EF-fibers). A pin-on-disc tribometer is used to investigate the frictional behavior of the composites in sliding contact with a granite counter surface. The results show that, after the run-in phase, Amontons’ law is valid for those composites that are reinforced by short-cut aramid fibers (without reinforcing filler, i.e., silica) if the contact pressure is below a threshold value. However, once the contact pressure exceeds this threshold value, Amontons’ law will be invalid. The threshold contact pressure of the composites containing EF-fibers is higher than of the composites containing SF-fibers. The composites that are reinforced by silica and short-cut aramid fibers do not follow Amontons’ law.
Molecular dynamics simulations of CH4 diffusion in kaolinite: influence of water content
Authors: Zhang Bin , Kang Jianting , Kang Tianhe , Kang Guanxian , Zhao Guofei
Published: October 2019

Understanding the interaction of CH4 with kaolinite is significant for researchers in the fields of coalbed CH4 and shale gas. The diffusion behaviors of CH4 in kaolinite with water contents ranging from 0 to 5 wt% have been analyzed by molecular dynamics simulations. The results of the simulations indicate that CH4 molecules can jump between adjacent holes in the kaolinite matrix. CH4 diffusion coefficient was very low (3.28 × 10−9 m2/s) and increased linearly with the increasing of water content. As the water content decreased, the value of radial distribution function first peak between CH4 and oxygen was larger, meaning that with lower water content, the interaction energy between CH4 and oxygen in kaolinite is stronger. The interaction between CH4 and water is linearly positively correlated with water content, in contrast, the interaction energy between kaolinite and water as well as between kaolinite and CH4 decreased linearly with increasing water content. On the other hand, the diffusion of CH4 molecules adsorbed on the surfaces also can be accelerated by the fast diffusion of water molecules in the middle micropore of the kaolinite.
Effect of excitation frequency on flow characteristics around a square cylinder with a synthetic jet positioned at front surface
Authors: Qu Yuan , Wang Jinjun , Feng Lihao , He Xi
Published: October 2019

The flow over a square cylinder controlled by a slot synthetic jet positioned at the front surface is investigated experimentally at different excitation frequencies. The Reynolds number based on the free-stream velocity and the side length of the square cylinder is 1000. The flow visualization was conducted using the laser-induced fluorescence technique. The velocity fields upstream and downstream of the square cylinder were measured synchronously with the two-dimensional time-resolved particle image velocimetry technique. Both the evolution of vortex structures and the characteristic frequencies of upstream and downstream flow fields are presented. The flow dynamics vary significantly with the excitation frequency at a fixed stroke length. During one excitation cycle, the synthetic jet vortex pair deflects to one side and later swings to the other side at a quite small excitation frequency of $f_{e}/f_{0}=0.6$, while it only deflects toward one side and does not turn to the other side at $f_{e}/f_{0}=1.0$. Compared with the natural case, the wake characteristics for the above two cases are not changed much by the synthetic jet adopted. At a moderate excitation frequency of $f_{e}/f_{0}=2.0$, the synthetic jet deflects upwards and downwards alternatively. The upstream flow field has a dominant frequency identical to half of the excitation frequency. Under the perturbations of the synthetic jet, two wake vortex pairs are formed per shedding cycle with a shedding frequency equal to that of the square cylinder without control. At a higher excitation frequency of $f_{e}/f_{0}=3.4$, the synthetic jet keeps deflecting to one side, and the upstream flow field is governed by the excitation frequency. The flow separation on the deflected side is suppressed effectively, and no periodic vortex shedding can be observed in the wake. Statistically, the velocity profiles also change with control. The recirculation bubble length in the wake is shortened, and the time-averaged velocity fluctuation is weakened remarkably. The control effects of the synthetic jet and the continuous jet are compared in this paper when placed at the front surface of a square cylinder.
Bomb 14C on paper and detection of the Forged Paintings of T’ang Haywen
Authors: Hajdas Irka , Koutouzis Philippe , Tai Kate , Hendriks Laura , Maurer Mantana , Röttig Maria Belen
Published: October 2019

The bomb-peak signal preserved in the Arches® cotton paper was used to detect art forgeries imitating the work of Chinese artist T’ang Haywen (1927–1991). The dating of seven legitimate T’ang Haywen art pieces showed that the timing of the paper production was consistent with the artist’s use of Arches® paper starting in the early 1980s. The measured F14C of the paper from the 14 suspected forged paintings shows that the support material was produced in the last decade (2008–2011), therefore the art pieces could not be genuine T’ang Haywen works.
Le fédéralisme de réconciliation et les Peuples Autochtones : ébauche d'une proposition institutionnelle
Authors: Mejía Mesa Oscar
Published: October 2019

La Commission de vérité et réconciliation du Canada (CVRC) réitérait en 2015 la volonté des Peuples Autochtones de renouveler leur relation avec l’État canadien. Cet article présente une réflexion théorique sur les possibilités offertes par le fédéralisme afin de renouveler cette relation entre les Autochtones et l’État. L'article confronte les arguments des tenants du fédéralisme comme cadre des relations entre les Autochtones et l’État et ceux des critiques de l’établissement d'un rapport fédéral de nation à nation entre les Peuples Autochtones et le Canada. L'article présente donc une proposition pour le renouvellement de la relation entre les Autochtones et l’État à travers un modèle de fédéralisme basé autour de régions autochtones autonomes.
Indonesian Bajau (East Lombok)
Authors: Archangeli Diana , Yip Jonathan , Yiu Suki
Published: October 2019

Bajau is spoken as the primary language from the Philippines to Borneo to eastern Indonesia, by both nomadic and settled communities. It is also known as Badjaw, Badjo, Bajao, Bajo, Bayo, Gaj, Indonesian Bajaw, Orang Laut, Sama, and Terijene; see Simons & Fennig 2017. Glottolog.org lists ‘Indonesian Bajau’ as a language spoken on the south-eastern coast of Sulawesi, glottocode indo1317 and ISO 639-3 bdl. Clifton (2010) claims the population of Bajau speakers is 700,000–900,000, with around 150,000–230,000 in eastern Indonesia (Sather 1997) and 92,000 in Sulawesi (Mead & Lee 2007). There are also Bajau-speaking populations in the Philippines and Borneo (Jun 2005); see Figure 1. Bajau is classified as a threatened Austronesian, Malayo-Polynesian language (Simons & Fennig 2017). It has been proposed that the language originated in the Zamboanga-Basilan area in southern Philippines (Jun 2005 citing Pallesen 1985).
Space Weather Aviation Forecasting on a Global Scale
Authors: Knipp Delores , Hapgood Michael
Published: October 2019

Under a new mandate, consortia of the world’s major space weather centers will disseminate new space-weather advisories for civil aviators representing a significant change-of-state for space weather.
Global Ten‐Moment Multifluid Simulations of the Solar Wind Interaction with Mercury: From the Planetary Conducting Core to the Dynamic Magnetosphere
Authors: Dong Chuanfei , Wang Liang , Hakim Ammar , Bhattacharjee Amitava , Slavin James A. , DiBraccio Gina A. , Germaschewski Kai
Published: October 2019

For the first time, we explore the tightly coupled interior‐magnetosphere system of Mercury by employing a three‐dimensional ten‐moment multifluid model. This novel fluid model incorporates the nonideal effects including the Hall effect, electron inertia, and tensorial pressures that are critical for collisionless magnetic reconnection; therefore, it is particularly well suited for investigating collisionless magnetic reconnection in Mercury's magnetotail and at the planet's magnetopause. The model is able to reproduce the observed magnetic field vectors, field‐aligned currents, and cross‐tail current sheet asymmetry (beyond magnetohydrodynamic approach), and the simulation results are in good agreement with spacecraft observations. We also study the magnetospheric response of Mercury to a hypothetical extreme event with an enhanced solar wind dynamic pressure, which demonstrates the significance of induction effects resulting from the electromagnetically coupled interior. More interestingly, plasmoids (or flux ropes) are formed in Mercury's magnetotail during the event, indicating the highly dynamic nature of Mercury's magnetosphere.
Is the Net Cloud Radiative Effect Constrained to be Uniform Over the Tropical Warm Pools?
Authors: Wall Casey J. , Hartmann Dennis L. , Norris Joel R.
Published: October 2019

Global radiative‐convective equilibrium simulations are used to investigate the hypothesis that mutual interactions among cloud albedo, sea surface temperature gradients, and atmospheric circulation constrain the net cloud radiative effect (CRE) to be similar in convective and nonconvective regions over the tropical warm pools. We perform an experiment in which convective clouds interact naturally with the ocean and atmosphere by forming over the warmest water and shading it and an experiment in which this interaction is removed by randomizing cloud shading of the ocean. Removing the cloud shading interaction enhances sea surface temperature gradients, lateral atmospheric heat transport, and large‐scale convective aggregation and produces convective clouds with much more negative net CRE. These findings support the hypothesis that feedbacks between sea surface temperature and convection are critical to obtaining similar net CRE in convective and nonconvective regions over the tropical warm pools.
Spatiotemporal Variability of Sea Ice in the Arctic's Last Ice Area
Authors: Moore G. W. K. , Schweiger A. , Zhang J. , Steele M.
Published: October 2019

The Arctic Ocean's oldest and thickest sea ice lies along the ~2,000 km arc from the western Canadian Arctic Archipelago to the northern coast of Greenland. Climate models suggest that this region will be the last to lose its perennial ice cover, thus providing an important refuge for ice‐dependent species. However, remarkably little is known about the climate or characteristics of the sea ice in this remote and inhospitable region. Here, we use the Pan‐Arctic Ice Ocean Modeling and Assimilation System model to show that the ice cover in the region is very dynamic, with changes occurring at a rate twice that of the Arctic Ocean as a whole. However, there are some differences in the changing nature of the ice cover between the eastern and western regions of the Last Ice Area, which include different timing of the annual minimum in ice thickness as well as distinct ice motion patterns associated with ice thickness extrema.
Reduced Atmospheric Ion Escape Above Martian Crustal Magnetic Fields
Authors: Fan Kai , Fraenz Markus , Wei Yong , Han Qianqian , Dubinin Eduard , Cui Jun , Chai Lihui , Rong Zhaojin , Zhong Jun , Wan Weixing , Mcfadden James , Connerney J.E.P.
Published: October 2019

Martian crustal fields were considered as too weak to have a distinctive effect on global escape rates of Martian heavy ions. However, new observations by the Mars Atmosphere and Volatile Evolution mission reveal a more precise result and show a notably lower atmospheric ion escape region above the area of the strongest crustal fields. A comparison between the fluxes of high and low energy O+ ions suggests that the strongest crustal fields may trap low energy ions and reduce the solar wind pick‐up efficiency while high energy ions form a flux depletion above the crustal field. Statistical results indicate a maximum reduction of the global escape flux by nearly 35% when the strongest crustal field region is oriented sunward. This is the first time that the protective effect of the crustal fields on heavy planetary ions has been observed and it might indicate a more effective protection of atmospheres by stronger magnetic fields like at Earth.
The July 2019 Ridgecrest, California, Earthquake Sequence: Kinematics of Slip and Stressing in Cross‐Fault Ruptures
Authors: Barnhart William D. , Hayes Gavin P. , Gold Ryan D.
Published: October 2019

The July 2019 Ridgecrest, California, earthquake sequence produced cross‐fault ruptures from a Mw6.4 left‐lateral foreshock and a Mw7.1 right‐lateral mainshock. We use interferometric synthetic aperture radar and satellite optical imagery to characterize the surface displacements and subsurface fault slip characteristics of the sequence. We document ~46 km of surface rupture and peak slip values of ~5 m associated with the Mw7.1 and evidence that the two ruptures crossed each other. We additionally document evidence of triggered creep along 20–25 km of the central Garlock fault. Static stress change analysis shows that the foreshock sequence systematically promoted slip at the Mw7.1 hypocenter. Moreover, we find static stress changes promoted slip on the Garlock fault only in locations where we document surface creep, strongly indicating that the Garlock fault is sensitive to static stress changes. A potential rupture of the Garlock fault where slip was promoted could produce a Mw6.7–7.0 earthquake.
RBSP‐ECT Combined Spin‐Averaged Electron Flux Data Product
Authors: Boyd A. J. , Reeves G. D. , Spence H. E. , Funsten H. O. , Larsen B. A. , Skoug R. M. , Blake J. B. , Fennell J. F. , Claudepierre S. G. , Baker D. N. , Kanekal S. G. , Jaynes A. N.
Published: October 2019

We describe a new data product combining the spin‐averaged electron flux measurements from the Radiation Belt Storm Probes (RBSP) Energetic Particle Composition and Thermal Plasma (ECT) suite on the National Aeronautics and Space Administration's Van Allen Probes. We describe the methodology used to combine each of the data sets and produce a consistent set of spectra for September 2013 to the present. Three‐minute‐averaged flux spectra are provided spanning energies from 15 eV up to 20 MeV. This new data product provides additional utility to the ECT data and offers a consistent cross calibrated data set for researchers interested in examining the dynamics of the inner magnetosphere across a wide range of energies.
Studying Dawn‐Dusk Asymmetries of Mercury's Magnetotail Using MHD‐EPIC Simulations
Authors: Chen Yuxi , Tóth Gábor , Jia Xianzhe , Slavin James A. , Sun Weijie , Markidis Stefano , Gombosi Tamas I. , Raines Jim M.
Published: October 2019

MESSENGER has observed a lot of dawn‐dusk asymmetries in Mercury's magnetotail, such as the asymmetries of the cross‐tail current sheet thickness and the occurrence of flux ropes, dipolarization events, and energetic electron injections. In order to obtain a global pictures of Mercury's magnetotail dynamics and the relationship between these asymmetries, we perform global simulations with the magnetohydrodynamics with embedded particle‐in‐cell (MHD‐EPIC) model, where Mercury's magnetotail region is covered by a PIC code. Our simulations show that the dawnside current sheet is thicker, the plasma density is larger, and the electron pressure is higher than the duskside. Under a strong interplanetary magnetic field driver, the simulated reconnection sites prefer the dawnside. We also found the dipolarization events and the planetward electron jets are moving dawnward while they are moving toward the planet, so that almost all dipolarization events and high‐speed plasma flows concentrate in the dawn sector. The simulation results are consistent with MESSENGER observations.
A Recurrent Magmatic Pattern on Observable Timescales Prior to Plinian Eruptions From Nevado de Toluca (Mexico)
Authors: Weber Gregor , Arce José Luis , Ulianov Alexey , Caricchi Luca
Published: October 2019

Nevado de Toluca is a stratovolcano in the densely populated Mexican Highland and the source of three late Pleistocene Plinian eruptions. While the characterization of the magmatic processes and timescales, leading to these events, is crucial to evaluate potential signals of the reawakening of this volcano, they are not well constrained. Here we present insights gathered from the analysis of mineral zoning. Abrupt changes in plagioclase compositions (anorthite [An] >10 mol. %) record repeated thermochemical disturbance of a shallow magma reservoir prior to the three eruptions investigated. In particular, sudden chemical changes in the outermost crystal rims indicate that the eruptions were triggered by recharge of less evolved magma. Recalculated melt compositions reveal that magma input is chemically heterogeneous. Orthopyroxene compositions span a large range (En53‐En92, Cr2O3 of up to 0.9 wt. %) resulting from magma hybridization, which is consistent with a late‐stage temperature increase recorded by amphibole chemistry. Using diffusion chronometry, we show that this recharge typically occurs decades to centuries before Plinian eruptions and hence on timescales relevant for volcano monitoring. Additionally, modeling of Mg profiles in plagioclase constraints the duration of differentiation cycles to be millennial in order of magnitude. Our study shows that similar processes preceded explosive eruptions from Nevado de Toluca, suggesting that analogous paths of unrest should be considered when evaluating potential future activity. We emphasize that signs of deep crustal activity, such as relatively broad deformation pattern surrounding the volcano, could herald the reactivation of Nevado de Toluca.
Boulder Distributions Around Young, Small Lunar Impact Craters and Implications for Regolith Production Rates and Landing Site Safety
Authors: Watkins R. N. , Jolliff B. L. , Mistick K. , Fogerty C. , Lawrence S. J. , Singer K. N. , Ghent R. R.
Published: October 2019

We use Lunar Reconnaissance Orbiter Camera Narrow Angle Camera images to characterize boulder populations around six small (<1 km), young (<200 Ma) impact craters near spacecraft landing sites. The Narrow Angle Camera boulder counts are used to analyze how boulder distributions vary around craters of different sizes and ages. These comparisons inform how various properties affect the distance to which boulders are ejected and the size and density of boulders produced by an impact event. The counts show that boulder population densities decrease with crater age, with few boulders remaining at craters older than a few hundred million years, consistent with results of other studies of boulder degradation rates on the Moon. Variations in boulder distributions around younger craters may provide information regarding impact conditions; South Ray crater has a larger population of small boulders than the larger North Ray crater, which could be explained by variations in impact velocity. Large craters generally excavate more boulders than smaller craters, and the size of the largest boulder ejected is related to crater size by a power‐law function. Larger boulders occur closer to the crater rim (within 2–4 crater radii), whereas smaller boulders occur at all distances. The density of boulders is greater near the crater rim and decreases with increasing radial distance; this data can aid in establishing safe landing zones for future missions. Analyzing boulder distributions across craters of varying ages allows us to test models of boulder breakdown rates, with implications for understanding the Moon's regolith production rate.
Impacts of environmental and socio-economic factors on emergence and epidemic potential of Ebola in Africa
Authors: Redding David W. , Atkinson Peter M. , Cunningham Andrew A. , Lo Iacono Gianni , Moses Lina M. , Wood James L. N. , Jones Kate E.
Published: October 2019

Recent outbreaks of animal-borne emerging infectious diseases have likely been precipitated by a complex interplay of changing ecological, epidemiological and socio-economic factors. Here, we develop modelling methods that capture elements of each of these factors, to predict the risk of Ebola virus disease (EVD) across time and space. Our modelling results match previously-observed outbreak patterns with high accuracy, and suggest further outbreaks could occur across most of West and Central Africa. Trends in the underlying drivers of EVD risk suggest a 1.75 to 3.2-fold increase in the endemic rate of animal-human viral spill-overs in Africa by 2070, given current modes of healthcare intervention. Future global change scenarios with higher human population growth and lower rates of socio-economic development yield a 1.63-fold higher likelihood of epidemics occurring as a result of spill-over events. Our modelling framework can be used to target interventions designed to reduce epidemic risk for many zoonotic diseases.
Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia
Authors: Paik Hyojung , Kan Matthew J. , Rappoport Nadav , Hadley Dexter , Sirota Marina , Chen Bin , Manber Udi , Cho Seong Beom , Butte Atul J.
Published: October 2019

The identification of novel disease associations using big-data for patient care has had limited success. In this study, we created a longitudinal disease network of traced readmissions (disease trajectories), merging data from over 10.4 million inpatients through the Healthcare Cost and Utilization Project, which allowed the representation of disease progression mapping over 300 diseases. From these disease trajectories, we discovered an interesting association between schizophrenia and rhabdomyolysis, a rare muscle disease (incidence < 1E-04) (relative risk, 2.21 [1.80–2.71, confidence interval = 0.95], P-value 9.54E-15). We validated this association by using independent electronic medical records from over 830,000 patients at the University of California, San Francisco (UCSF) medical center. A case review of 29 rhabdomyolysis incidents in schizophrenia patients at UCSF demonstrated that 62% are idiopathic, without the use of any drug known to lead to this adverse event, suggesting a warning to physicians to watch for this unexpected risk of schizophrenia. Large-scale analysis of disease trajectories can help physicians understand potential sequential events in their patients.