bluuebunny/crossref_metadata_2025 huggingface dataset:
Subtypes in Patients Taking Prescribed Opioid Analgesics and Their Characteristics: A Latent Class Analysis
Authors: Rauschert Christian , Seitz Nicki-Nils , Olderbak Sally , Pogarell Oliver , Dreischulte Tobias , Kraus Ludwig
Published: July 2022

Background

Owing to their pharmacological properties the use of opioid analgesics carries a risk of abuse and dependence, which are associated with a wide range of personal, social, and medical problems. Data-based approaches for identifying distinct patient subtypes at risk for prescription opioid use disorder in Germany are lacking.

Objective

This study aimed to identify distinct subgroups of patients using prescribed opioid analgesics at risk for prescription opioid use disorder.

Methods

Latent class analysis was applied to pooled data from the 2015 and 2021 Epidemiological Survey of Substance Abuse. Participants were aged 18–64 years and self-reported the use of prescribed opioid analgesics in the last year (n = 503). Seven class-defining variables based on behavioral, mental, and physical health characteristics commonly associated with problematic opioid use were used to identify participant subtypes. Statistical tests were performed to examine differences between the participant subtypes on sociodemographic variables and prescription opioid use disorder.

Results

Three classes were extracted, which were labeled as poor mental health group (43.0%, n = 203), polysubstance group (10.4%, n = 50), and relatively healthy group (46.6%, n = 250). Individuals within the poor mental health group (23.2%, n = 43) and the polysubstance group (31.1%, n = 13) showed a higher prevalence of prescription opioid use disorder compared to those of the relatively healthy group.

Conclusion

The results add further evidence to the knowledge that patients using prescribed opioid analgesics are not a homogeneous group of individuals whose needs lie in pain management alone. Rather, it becomes clear that these patients differ in their individual risk of a prescription opioid use disorder, and therefore identification of specific risks plays an important role in early prevention.
Exploring Factors Affecting Health Care Providers' Behaviors for Maintaining Continuity of Care in Kerala, India; A Qualitative Analysis Using the Theoretical Domains Framework
Authors: Joseph Linju , Greenfield Sheila , Lavis Anna , Lekha T. R. , Panniyammakal Jeemon , Manaseki-Holland Semira
Published: July 2022

Introduction

Access to patients' documented medical information is necessary for building the informational continuity across different healthcare providers (HCP), particularly for patients with non-communicable diseases (NCD). Patient-held health records (PHR) such as NCD notebooks have important documented medical information, which can contribute to informational continuity in the outpatient settings for patients with diabetes and hypertension in Kerala. We aimed to use the theoretical domains framework (TDF) to identify the perceived HCP factors influencing informational and management continuity for patients with diabetes and hypertension.

Methods

We re-analyzed semi-structured interview data for 17 HCPs with experience in the NCD programme in public health facilities in Kerala from a previous study, using the TDF. The previous study explored patients, carers and HCPs experiences using PHRs such as NCD notebooks in the management of diabetes and hypertension. Interview transcripts were deductively coded based on a coding framework based on the 14 domains of TDF. Specific beliefs were generated from the data grouped into the domains.

Results

Data were coded into the 14 domains of TDF and generated 33 specific beliefs regarding maintaining informational and management continuity of care. Seven domains were judged to be acting as facilitators for recording in PHRs and maintaining continuity. The two domains “memory, attention and decision process” and “environmental context and resources” depicted the barriers identified by HCPs for informational continuity of care.

Conclusion

In this exploration of recording and communicating patients' medical information in PHRs for patients with diabetes and hypertension, HCPs attributions of sub-optimal recording were used to identify domains that may be targeted for further development of supporting intervention. Overall, nine domains were likely to impact the barriers and facilitators for HCPs in recording in PHRs and communicating; subsequently maintaining informational and management continuity of care. This study showed that many underlying beliefs regarding informational continuity of care were based on HCPs' experiences with patient behaviors. Further research is needed for developing the content and appropriate support interventions for using PHRs to maintain informational continuity.
Psychological Wellbeing and Employability of Retrenched Workforce During COVID-19: A Qualitative Study Exploring the Mitigations for Post Pandemic Recovery Phase
Authors: Ke Guek-Nee , Grajfoner Dasha , Carter Stephen , DeLima Nicole , Khairudin Rozainee , Lau Wee-Yeap , Kamal Khalil Anwar , Lee Shen Chieng
Published: July 2022

The ongoing COVID-19 pandemic has triggered several employment-related issues, followed by different response strategies. With retrenchment measures being a common response strategy during economic downturns, many individuals have been faced with unemployment. This study aimed to explore the effect of the COVID-19 pandemic related retrenchment on the psychological wellbeing of the Malaysian workforce, using a qualitative research approach and based on the Latent-deprivation Model. A purposive sample of 30 retrenched participants was interviewed via telephone during Malaysia's Movement Control Order (MCO). Thematic analysis was subsequently conducted to identify key themes in the data set. Six themes emerged from the thematic analysis: (1) Retrenchment leading to the deterioration of psychological wellbeing; (2) Unemployment, financial strain and economic uncertainty; (3) Emotions related to the COVID-19 virus; (4) Coping with lifestyle change; (5) Recommendations to improve the psychological wellbeing and mental health of the retrenched workforce, and (6) Career and financial support at the recovery phase. The present study provides valuable insight into the wellbeing of retrenched workforce who are forced to cope with both unemployment and a global pandemic, and workforce perspectives regarding types of support needed during the recovery phase.
COVID-19 Lockdown and Lifestyle Changes in Saudi Adults With Types 1 and 2 Diabetes
Authors: Al-Daghri Nasser M. , Almiman Abeer A. , Wani Kaiser , Khattak Malak N. K. , Aljohani Naji J. , Alfawaz Hanan , Al-Hameidi Abdulaziz , Aldisi Dara , Alkhaldi Ghadah , Sabico Shaun
Published: July 2022

Objective

We aimed to evaluate and compare the impact of COVID-19 lockdown on lifestyle changes and other common related effects of the lockdown in Saudi adults with diabetes mellitus (DM), both type 1 (T1D) and type 2 diabetes (T2D).

Methods

265 T1D and 285 T2D individuals were included in this cross-sectional survey during lockdown using an online questionnaire and compared with 297 participants without DM. Variables included demographics, treatment changes, use of supplements, change in sleeping habits and physical activity, dietary changes, social and mental health, and education and awareness during COVID-19 lockdown.

Results

The COVID-19 lockdown was associated with more treatment doses in people with T1D but not in those with T2D (p = 0.003). More participants with T1D and T2D than the control group reported that they felt symptoms of depression during lockdown (ORs of 1.83, p = 0.008 and 2.2, p = 0.001, respectively) and that lockdown affected them psychologically (ORs of 1.64, p = 0.019 and 1.85, p = 0.005, respectively). More participants with T1D than controls reported that their physical activity decreased during lockdown (OR of 2.70, p = 0.024). Furthermore, significantly lesser participants in both DM groups than controls agreed that the health education regarding COVID-19 covered everything (ORs of 0.41, p < 0.001 and 0.56, p < 0.001, respectively for T1D and T2D groups). Regarding dietary habits, the DM groups reported more changes in either the number of daily meals, meal content, or mealtimes than the control group.

Conclusions

COVID-19 lockdown-associated lifestyle changes were more prevalent in individuals with T1D and T2D compared to control. Findings may assist public health authorities in outlining their responses in pandemics and promote healthy lifestyle adaptations in this high-risk cohort to limit adverse effects in future lockdowns.
Optimizing Smoking Cessation Counseling in a University Hospital: Results and Pitfalls
Authors: de Frel Daan L. , Janssen Veronica R. , Meijer Eline , Atsma Douwe E.
Published: July 2022

Background

Healthcare professionals (HPs) can play a substantial role in smoking cessation counseling (SCC) but in practice often skip this task due to time constraints. This study evaluates the implementation of the rapid Ask-Advise-Connect (AAC) method in a University hospital setting.

Methods

This mixed methods pre-post interventional study was performed at the Cardiology department of a University hospital and consisted of (1) a quantitative assessment of patient smoking registration and HP connection rates to external SCC from the Electronic Medical Record, (2) semi-structured interviews with 10 HPs to assess their attitudes toward AAC, and (3) a blended intervention aimed to implement AAC. The blended intervention consisted of face-to-face and online AAC psychoeducation for HPs followed-up with motivational messages on their smart pagers over a period of 6 weeks.

Results

In total, 48,321 patient registrations and 67 HPs were included. Before AAC implementation, HPs assessed smoking status in 74.0% of patients and connected 9.3% of identified smokers with SCC. Post intervention, these percentages did not increase (73.2%, p = 0.20; and 10.9%, p = 0.18, respectively). Nonetheless, the vast majority (90%) of HPs feel it is important to discuss patient smoking, and view it as their duty to do so. Main barriers to AAC reported by HPs were forgetfulness and time pressure.

Conclusion

This study shows that this AAC intervention does not increase Asking after smoking status or Connection of patients to SCC in a University Hospital. However, HPs hold positive attitudes toward AAC. A better understanding of the mechanisms required for optimizing HPs practice behavior is needed.
Local-To-Global Hypotheses for Robust Robot Localization
Authors: Hendrikx R. W. M. , Bruyninckx H. , Elfring J. , Van De Molengraft M. J. G.
Published: July 2022

Many robust state-of-the-art localization methods rely on pose-space sample sets that are evaluated against individual sensor measurements. While these methods can work effectively, they often provide limited mechanisms to control the amount of hypotheses based on their similarity. Furthermore, they do not explicitly use associations to create or remove these hypotheses. We propose a global localization strategy that allows a mobile robot to localize using explicit symbolic associations with annotated geometric features. The feature measurements are first combined locally to form a consistent local feature map that is accurate in the vicinity of the robot. Based on this local map, an association tree is maintained that pairs local map features with global map features. The leaves of the tree represent distinct hypotheses on the data associations that allow for globally unmapped features appearing in the local map. We propose a registration step to check if an association hypothesis is supported. Our implementation considers a robot equipped with a 2D LiDAR and we compare the proposed method to a particle filter. We show that maintaining a smaller set of data association hypotheses results in better performance and explainability of the robot’s assumptions, as well as allowing more control over hypothesis bookkeeping. We provide experimental evaluations with a physical robot in a real environment using an annotated geometric building model that contains only the static part of the indoor scene. The result shows that our method outperforms a particle filter implementation in most cases by using fewer hypotheses with more descriptive power.
Interaction Matters: The Effect of Touching the Social Robot PARO on Pain and Stress is Stronger When Turned ON vs. OFF
Authors: Geva Nirit , Hermoni Netta , Levy-Tzedek Shelly
Published: July 2022

Social touch between humans, as well as between humans and animals, was previously found to reduce pain and stress. We previously reported that touching a social robot can also induce a reduction in pain ratings. However, it is unclear if the effect that touching a robot has on pain perception is due to its appearance and its pleasant touch, or due to its ability to socially interact with humans. In the current experiment, we aimed to assess the contribution of the interactive quality to pain perception. We assessed the effect of touching the social robot PARO on mild and strong pain ratings and on stress perception, on a total of 60 healthy young participants. The robot either interacted with participants (ON group, n = 30) or was turned off (OFF group, n = 30). Touching the robot induced a decrease in mild pain ratings (compared to baseline) only in the ON group while strong pain ratings decreased similarly in both the ON and the OFF groups. The decrease in mild pain ratings in the ON group was significantly greater in participants with a higher positive perception of the interaction with PARO. We conclude that part of the effect that touching the robot has on pain stems from its interactive features.
“After the Dust Settles”: Foucauldian Narratives of Retired Athletes' “Re-orientation” to Exercise
Authors: Jones Luke , Avner Zoe , Denison Jim
Published: July 2022

One aspect of sports retirement that has been overlooked until recently is the manner in which retired athletes relate to, and seek to redefine, the meaning of exercise in their post-sport lives. In this article, three Foucauldian scholars present and analyze a series of vignettes concerning their own sense-making and meaning-making about exercise following their long-term involvement in high-performance soccer (authors one and two) and distance running (author three). In doing so, this paper aims to underline the problematic legacy of high-performance sport for retiring athletes' relationship to movement and exercise, and to highlight how social theory, and Foucauldian theorization in particular, can serve to open new spaces and possibilities for thinking about sports retirement.
Welfare Effects of Agricultural Foreign Direct Investment in Developing Countries
Authors: Djokoto Justice Gameli , Agyei Henaku Kofi A. A-O , Badu-Prah Charlotte
Published: July 2022

Many developing countries have embraced policies to attract foreign direct investment into their respective economies including the agricultural sector to enhance technology transfer, employment, and trade among other benefits. On the other hand, foreign direct investment into the agricultural sector has been associated with competition with local agricultural produce from imported raw and processed products and land grabbing that has deprived farmers of land for cultivation. These could have implications for the investment and employment of indigenes in the agricultural sector and consequently welfare. This raises the question, does agricultural foreign direct investment promote or discourage welfare? In this paper, we assessed the welfare effects of agricultural foreign direct investment in developing countries. Using an unbalanced panel data of 51 developing countries from 1990 to 2019 with a fixed-effects estimator, we found that agricultural foreign direct investment promotes welfare in developing countries. Openness to trade, population growth, human capital, and infrastructure enhanced welfare. Whilst government expenditure did not promote welfare, inflation did not affect welfare. Whilst promoting foreign direct investment into agriculture, governments in developing countries must improve human capital, develop infrastructure, and pursue trade openness policies. Final government expenditure on goods and services needs to be redirected into funding projects and programmes that improve the health, education, and income of citizens, especially the poor.
Prospects and Potential of Bradyrhizobium diazoefficiens Based Bio-Inoculants on Soybean Production in Different Agro-Ecologies of Mozambique
Authors: Savala Canon Engoke Norris , Wiredu Alexander Nimo , Chikoye David , Kyei-Boahen Stephen
Published: July 2022

Soybean production in sub-Saharan Africa is increasing as farmers open more land areas for cultivation and replace other crops, such as tobacco, in favor of this legume crop. Despite the production is increased in Mozambique, demand for animal feed and oil is not satisfied. As such, farmers explore ways to improve yield per unit area of soybean by using bio-inoculants from various sources and agroecological adaptability. These bio-inoculants are seldom available during planting time, and retail at almost similar prices although yield varied based on the product source, handling, and the rhizobia strain carrier. Mozambique does not produce bio-inoculants, so it obtains the product from neighboring countries or as far as the South American continent. In this study, we evaluated the performance, ecological adaptability, and soybean productivity of seven Bradyrhizobium diazoefficiens strain-based bio-inoculants from several countries with different carrier materials: Biofix, Masterfix, Nitrofix, NitroZam, N-Fixer, Soygro Peat, and Soygro Liquid against a control (non-inoculated) on two soybean varieties Storm and TGx 1904-6F. The trial was conducted in the 2016 and 2017 growing seasons in three agroecologies of Mozambique at Angonia, Nampula, and Ruace. Data on nodulation, plant growth, biomass nitrogen content at beginning of podding (R3) stage, yield, and yield components of soybean were evaluated. Analysis of variance and contrast comparisons were performed on the Statistical Analysis System® 9.4. Nodule weight per plant variedly increased from 7.7 to 167.6 mg with inoculation of both varieties across environments. Plant tissue nitrogen content at the R3 stage was higher in inoculated non-promiscuous variety at 3.9% than the promiscuous counterpart with 3.7%. Storm, a non-promiscuous short-maturity variety of soybean, responded to inoculation and accumulated more N than the medium-to-late maturity promiscuous TGx 1904-6F. Higher N tissue content is an indicator of better nutritive value, as well as high-quality recyclable biomass of inoculated soybean. Both Storm and TGx 1904-6F responded to all inoculants variedly with NitroZam yield of 2,750 kg ha−1 being highest, while Soygro Liquid was lowest with 2,051 kg ha−1 but more than the check with 1,690 kg ha−1 across sites. There were varietal differences in 100-seed weight after inoculation where Storm (15.4 g) had heavier seeds than TGx 1904-6F (13.1 g). The results show that inoculation improved plant growth and development, increased nodulation, and gave higher yields for better economic returns among farmers. Inoculation has the potential of increasing soybean yield, nutritive value, and biomass quality within Mozambique.
End-of-Life Management Options for Agricultural Mulch Films in the United States—A Review
Authors: Madrid Brenda , Wortman Sam , Hayes Douglas G. , DeBruyn Jennifer M. , Miles Carol , Flury Markus , Marsh Thomas L. , Galinato Suzette P. , Englund Karl , Agehara Shinsuke , DeVetter Lisa Wasko
Published: July 2022

Polyethylene plastic mulches are widely used in specialty cropping systems in the United States due to the horticultural benefits they provide. However, polyethylene mulch is reapplied seasonally, generating large volumes of plastic waste that contribute to plastic pollution concerns. This review synthesizes scientific and industry findings to provide a state of current end-of-life options of polyethylene mulch in the United States and identifies opportunities that can improve plastic waste management with a special emphasis on soil-biodegradable plastic mulches. Major points discussed are: (1) polyethylene mulch use in specialty cropping systems, (2) economic, environmental and waste management impacts of polyethylene mulch use, (3) current common end-of-life pathways of used polyethylene mulch, (4) use of soil-biodegradable plastic mulch as an alternative to reduce the amount of plastic waste in the environment and offset the negative impacts associated with residual non-degradable plastics, (5) socioeconomic factors that reduce the adoption of soil-biodegradable plastic mulch, and (6) limitations of soil-biodegradable mulch. The results of this review conclude that recycling and upcycling of used polyethylene mulch can be a more sustainable disposal option, however cleaning and decontaminating used polyethylene mulch is costly and commercial technology is often not accessible nor economically viable in many regions in the current economic and political situation. To make recycling a viable pathway in the future, research and policy developments are necessary to refine and encourage recycling. Soil-biodegradable plastic mulches can offer an additional opportunity to help address these limitations, but they are not permitted in organic agriculture in the United States. Further studies are necessary to address the current knowledge gaps and gain a better understanding of the factors influencing the degradation of soil-biodegradable mulches under diverse field conditions. Improved end-of-life strategies should continue to be pursued that balance sustainable use of plastic mulch while minimizing environmental risks.
Lung Immune Prognostic Index Could Predict Metastasis in Patients With Osteosarcoma
Authors: He Xuanhong , Wang Yitian , Ye Qiang , Wang Yang , Min Li , Luo Yi , Zhou Yong , Tu Chongqi
Published: July 2022

Background

The lung immune prognostic index (LIPI), composed of serum lactate dehydrogenase (LDH) and the derived neutrophil to lymphocyte ratio (dNLR), is a novel prognostic factor of lung cancer. The prognostic effect of the LIPI has never been verified in osteosarcoma.

Methods

We retrospectively reviewed the osteosarcoma patients with metachronous metastasis from January 2016 to January 2021 in West China Hospital. We collected and analyzed the clinical data and constructed the LIPI for osteosarcoma. The correlation between the LIPI and metastasis was analyzed according to the Kaplan–Meier method and Cox regression analysis with hazard ratios (HRs) and 95% confidence intervals (CIs). Univariate analysis and multivariate analysis were conducted to clarify the independent risk factors of metastasis. The nomogram model was established by R software, version 4.1.0.

Results

The area under the curve (AUC) and best cutoff value were 0.535 and 91, 0.519, and 5.02, 0.594 and 2.77, 0.569 and 227.14, 0.59 and 158, and 0.607 and 2.05 for ALP, LMR, NLR, PLR, LDH, and dNLR, respectively. The LIPI was composed of LDH and dNLR and showed a larger AUC than other hematological factors in the time-dependent operator curve (t-ROC). In total, 184 patients, 42 (22.8%), 96 (52.2%), and 46 (25.0%) patients had LIPIs of good, moderate, and poor, respectively (P < 0.0001). Univariate analysis revealed that pathological fracture, the initial CT report of suspicious nodule, and the NLR, PLR, ALP, and the LIPI were significantly associated with metastasis, and multivariate analysis showed that the initial CT report of suspicious nodule and the PLR, ALP, and LIPI were dependent risk factors for metastasis. Metastatic predictive factors were selected and incorporated into the nomogram construction, including the LIPI, ALP, PLR, initial CT report, and pathological fracture. The C-index of our model was 0.71. According to the calibration plot, this predictive nomogram could accurately predict 3- and 5-year metachronous metastasis. Based on the result of decision curve and clinical impact curve, this predictive nomogram could also help patients obtain significant net benefits.

Conclusion

We first demonstrated the metastatic predictive effect of the LIPI on osteosarcoma. This LIPI-based model is useful for clinicians to predict metastasis in osteosarcoma patients and could help conduct timely intervention and facilitate personalized management of osteosarcoma patients.
Determinants of Rabies Post-exposure Prophylaxis Drop-Out in the Region of San-Pedro, Côte d'Ivoire
Authors: N'Guessan Rose Delima , Heitz-Tokpa Kathrin , Amalaman Djedou Martin , Tetchi Sopi Mathilde , Kallo Vessaly , Ndjoug Ndour Andrée Prisca , Nicodem Govella , Koné Issiaka , Kreppel Katharina , Bonfoh Bassirou
Published: July 2022

Despite the fact that death from rabies is 100% preventable with a course of post-exposure prophylaxis (PEP) treatment, canine rabies still causes about 59,000 human deaths worldwide annually, half of which are occurring in Africa. In Côte d'Ivoire, rabies remains a threat partly due to the high drop-out rate of the life-saving human PEP treatment among people exposed to dog bites. Each year, half of the victims starting treatment, do not complete the course. The current study therefore assessed the determinants for drop-out of the life-saving treatment among people exposed to rabies in the department of San-Pedro in Côte d'Ivoire.

Methods

A mixed-methods approach was used, including questionnaires, observation, individual interviews and focus group discussions, to gather socio-demographic and economic data from 235 participants about possible reasons for abandoning treatment. The study population consisted of patients and medical and veterinary health professionals who were selected using stratified sampling and purposive selection from a database available at the Rabies Center of San Pedro.

Result

The drop-out of PEP treatment was related to perception bias and a habit of low attendance of health care and vaccination centers in the population. Quantitative analysis shows differences between rural and urban areas and an association with age when it comes to treatment completion. The dropout rate was most significant among patients who, in case of other illness, did not routinely see a doctor or go to vaccination centers. The rate of abandonment was higher among those who believed that dog-related injuries could be easily treated at home, and who believed that a person with rabies could be cured without completing the preventive treatment. Insufficient provision of health information on rabies and logistic constraints related to the practical organization of treatment, including the long distance to the anti-rabies center and weaknesses in the patient follow-up procedure, did not contribute to the completion of PEP.

Conclusion

Established determinants for drop-out provide a framework for effective design and implementation of rabies control strategies to accelerate rabies deaths elimination efforts. In particular, access to PEP and community knowledge about rabies need to be improved and integrated in the health system and education system, respectively.
Molecular Detection of Zoonotic and Veterinary Pathogenic Bacteria in Pet Dogs and Their Parasitizing Ticks in Junggar Basin, North-Western China
Authors: Guo Jia , Song Shengnan , Cao Shuzhu , Sun Zhihua , Zhou Qiyue , Deng Xingmei , Zhao Tianyi , Chai Yingjin , Zhu Dexin , Chen Chuangfu , Baryshnikov P. I. , Blair Hugh T. , Wang Zhen , Wang Yuanzhi , Zhang Hui
Published: July 2022

Despite the recognized epidemiological importance of ticks as vectors for pathogens that cause numerous zoonotic and veterinary diseases, data regarding the pathogens of pet dogs and their parasitic ticks in the Junggar Basin are scarce. In this study, a total of 178 blood samples and 436 parasitic ticks were collected from pet dogs in Junggar Basin, Xinjiang Uygur Autonomous Region (XUAR), north-western China. All ticks were identified as Rhipicephalus turanicus sensu stricto (s.s.) according to morphological and molecular characteristics. Rh. turanicus s.s. ticks were collected from pet dogs in China for the first time. Seven tick-borne pathogens, such as Ehrlichia chaffeensis, Anaplasma phagocytophilum, Rickettsia massiliae, Candidatus R. barbariae, Brucella spp., Rickettsia sibirica, and Anaplasma ovis, were detected from ticks, whereas the first five bacteria were detected from blood samples of dogs. Brucella spp. was the most predominant pathogen in both blood samples and ticks of pet dogs, with the detection rates of 16.29 and 16.74%, respectively. Moreover, 17 ticks and 1 blood sample were co-infected with two pathogens, and 1 tick was co-infected with three pathogens. This study provided molecular evidence for the occurrence of Anaplasma spp., Ehrlichia spp., Rickettsia spp., and Brucella spp. circulating in pet dogs and their parasitic ticks in Junggar Basin, north-western China. These findings extend our knowledge of the tick-borne pathogens in pet dogs and their parasitic ticks in Central Asia; therefore, further research on these pathogens and their role in human and animal diseases is required.
PVDF Energy Harvester for Prolonging the Battery Life of Cardiac Pacemakers
Authors: Hu Christopher , Behdinan Kamran , Moradi-Dastjerdi Rasool
Published: July 2022

Patients who have an implantable cardiac pacemaker that survive beyond the operational life of the device require replacement surgeries that increase healthcare costs and may possibly introduce post-operative complications such as infection. In this paper, we propose a piezoelectric energy harvester design for powering pacemakers to extend their operational life. The design uses a thin strip of piezoelectric PVDF that captures energy from bending of the lead wire. We assemble a prototype to validate a finite element model, and then use the finite element model to characterize the power output of the design based on a cantilever beam loading condition, where displacement at the cantilever tip simulated heart motion. The voltage output from the prototype was compared to the output from the finite element simulation and the finite element simulation provided a good estimate of the voltage output. Further finite element analysis showed that for a 10 cm long section of the proposed design, a 9.1 mm tip displacement provided a power output of 1 μW and a voltage output of ±1.4 V during each cycle.
Supersonic Combustion Modeling and Simulation on General Platforms
Authors: Huang Shizhuo , Chen Qian , Cheng Yuwei , Xian Jinyu , Tai Zhengqi
Published: July 2022

Supersonic combustion is an advanced technology for the next generation of aerospace vehicles. In the last two decades, numerical simulation has been widely used for the investigation on supersonic combustion. In this paper, the modeling and simulation of supersonic combustion on general platforms are thoroughly reviewed, with emphasis placed on turbulence modeling and turbulence–chemistry interactions treatment which are both essential for engineering computation of supersonic combustion. It is found that the Reynolds-averaged Navier–Stokes methods on the general platforms have provided useful experience for the numerical simulation in engineering design of supersonic combustion, while the large eddy simulation methods need to be widely utilized and further developed on these platforms. Meanwhile, the species transport models as a kind of reasonable combustion model accounting for the turbulence–chemistry interactions in supersonic combustion have achieved good results. With the development of new combustion models, especially those designed in recent years for high-speed combustion, the turbulence–chemistry interactions treatment for numerical simulation of supersonic combustion based on general platforms is expected to be further mature in the future.
Accumulation and Health Risk Assessment of Heavy Metal(loid)s in Soil-Crop Systems from Central Guizhou, Southwest China
Authors: Li Xuexian , Liu Nanting , Meng Wei , He Jin , Wu Pan
Published: July 2022

Heavy metal(loid)s (HMs) contamination in agricultural soil and crops is related to the quality and safety of agricultural products and public health and has attracted worldwide attention. This study systematically investigated the bioaccumulation of HMs including Cd, Pb, Cr, Hg, As and Se in soil and associated crops (Tea, Plum and Corn) in Guizhou Province, China, and assessed the health risks of the edible part of the crops using the bioconcentration factor (BCF), geoaccumulation index (Igeo), and target hazard quotient (THQ). The results indicate that the mean concentrations of Pb (39.54 ± 16.56 mg/kg), Cr (122.50 ± 33.36 mg/kg), Hg (0.26 ± 0.33 mg/kg), As (25.40 ± 21.34 mg/kg), and Se (0.90 ± 0.46 mg/kg) in cultivated soil exceed the background values of Guizhou Province by 1.12, 1.28, 2.36, 1.27, and 2.4 times, respectively. However, the average concentration of Cd is 0.49 ± 0.49 mg/kg, which is lower than the corresponding background value. The average Igeo values of Pb, Cd, Cr, and As in the soil samples were lower than 1, indicating a relatively low degree of enrichment, whereas the enrichment of Hg was relatively obvious, as approximately 32.9% of the samples were at moderate and above enrichment levels. The contents of HMs in samples of corn, plum, and tea were lower than the corresponding pollutant limit. The BCF values of Cd, Hg, and Se in the three crops were relatively high, indicating a strong migration ability, and the average BCF values of tea in the soil-crop system were higher than those of corn and plum. Correlation analysis showed that the soil pH and concentrations of K2O, Fe2O3, and Al2O3 were negatively correlated with the BCF of Pb, Cr, and Hg in the soil-crop system, indicating that they were affected by macro-oxidation in the soil, whereas Cd and As were basically not affected. The human health risk assessment of THQ values demonstrated that the health risks to local residents from eating corn and drinking tea were low.
Spatial and Temporal Changes in Crop Species Production Diversity in Mexico (1980–2020)
Authors: LaFevor Matthew C.
Published: July 2022

Crop species diversity is a key component of agroecosystem resilience, food system stability, ecosystem services production, and sustainable development. Despite its importance, quantitative understanding of crop species diversity is often lacking. This study assesses changes in crop species production diversity in Mexico from 1980 to 2020 at state, regional, and national levels. Measures of crop species richness and effective diversity (alpha, beta, gamma) were derived from government production data on 304 species, each stratified into rainfed and irrigated components. Time series of these components reveal three main findings: (1) diversity generally increased during the study period, especially among fruits, vegetables, spices and herbs, and ornamental crops; (2) the diversity of irrigated crops was about two times higher than the diversity of rainfed crops, despite comprising a small fraction of the total cultivated area; and (3) the diversity of irrigated crops increased dramatically after implementation of the North American Free Trade Agreement (NAFTA) in 1994—though most increases occurred in dry northern regions where production depended on unsustainable irrigation. In sum, findings show that while crop diversity can contribute to numerous forms of sustainability, not all diversification processes derive from agroecologically-based, sustainable forms of intensification. In Mexico, crop species diversification was associated with a post-1994 boom in produce exports to the United States and the unsustainable use of scarce water resources at home. Such context-specific understanding is crucial for determining whether crop diversification, in all its forms, ultimately leads to sustainable outcomes.
Tomato Maturity Classification Based on SE-YOLOv3-MobileNetV1 Network under Nature Greenhouse Environment
Authors: Su Fei , Zhao Yanping , Wang Guanghui , Liu Pingzeng , Yan Yinfa , Zu Linlu
Published: July 2022

The maturity level of tomato is a key factor of tomato picking, which directly determines the transportation distance, storage time, and market freshness of postharvest tomato. In view of the lack of studies on tomato maturity classification under nature greenhouse environment, this paper proposes a SE-YOLOv3-MobileNetV1 network to classify four kinds of tomato maturity. The proposed maturity classification model is improved in terms of speed and accuracy: (1) Speed: Depthwise separable convolution is used. (2) Accuracy: Mosaic data augmentation, K-means clustering algorithm, and the Squeeze-and-Excitation attention mechanism module are used. To verify the detection performance, the proposed model is compared with the current mainstream models, such as YOLOv3, YOLOv3-MobileNetV1, and YOLOv5 in terms of accuracy and speed. The SE-YOLOv3-MobileNetV1 model is able to distinguish tomatoes in four kinds of maturity, the mean average precision value of tomato reaches 97.5%. The detection speed of the proposed model is 278.6 and 236.8 ms faster than the YOLOv3 and YOLOv5 model. In addition, the proposed model is considerably lighter than YOLOv3 and YOLOv5, which meets the need of embedded development, and provides a reference for tomato maturity classification of tomato harvesting robot.
Remediation of Lead Contamination by Aspergillus niger and Phosphate Rocks under Different Nitrogen Sources
Authors: Feng Yi , Zhang Liangliang , Li Xiang , Wang Liyan , Yusef Kianpoor Kalkhajeh , Gao Hongjian , Tian Da
Published: July 2022

Co-application of Aspergillus niger (A. niger) and phosphate rocks (PR) has been practiced by environmentalists for lead (Pb) remediation. The secretion of organic acid by A. niger usually dominates the dissolution of PR and Pb immobilization. In this study, two types of PR (fluorapatite (FAp) and phosphogypsum (PG)) were investigated in Pb remediation by A. niger under three different forms of nitrogen (ammonium, nitrate, and urea). Our results reveal that the formation of pyromorphite and lead oxalate contributed to Pb removal by the combination of A. niger with FAp and PG. PG showed a significant capability for Pb remediation compared with FAP, over 94% of Pb vs. 50%. Compared with nitrate and urea, ammonium significantly decreased Pb cation concentrations from 1500 mg/L to 0.4 mg/L. Due to ammonium containing sulfate, the lead sulfate formed also contributed to Pb removal. However, nitrate stimulated A. niger to secrete more oxalic acid (~1400 mg/L) than ammonium and urea (~200 mg/L), which can form insoluble lead oxalate. These insoluble minerals can reduce the availability of removed Pb. Despite the efficacy of both ammonium and nitrate for Pb remediation, our findings suggest that nitrate is the primary candidate in this regard due to high oxalic acid secretion.
Grain Dehydration Characteristics of Old and Modern Maize Hybrids and Their Response to Different Planting Densities
Authors: Guo Huaihuai , Yu Xiaofang , Gao Julin , Ma Daling , Hu Shuping , Wang Xian
Published: July 2022

High grain water content at harvest stage is the main limiting factor for realizing mechanized maize grain harvest in China. Under the background of yield gain by density increase, it is necessary to clarify the effect of planting density increase on maize grain dehydration characteristics, which would provide theoretical support for realizing mechanized grain harvest under high planting density conditions. Therefore, this study selects five main hybrids, ZD2, DY13, YD13, XY335, and DH618, released in different eras that were widely promoted in Inner Mongolia from the 1970s to 2010s. The experiment was conducted in the Chilechuan Modern Agriculture Expo Park, Tumed Right Banner, Baotou city, Inner Mongolia, in 2018 and 2019. Under the three densities of 45,000 plants ha−1 (low density), 75,000 plants ha−1 (medium density) and 105,000 plants ha−1 (high density), the indexes of grain dehydration, leaf stay-green, bract and cob dehydration of the different maize hybrids were measured and analyzed. The results show that MCpm (moisture content at physiological maturity) of hybrids in the 1970s and 1990s was significantly reduced by 1.57 and 1.14 percentage points, respectively, and MCh (moisture content at harvest time) in the harvest period of hybrids in the 1970s was significantly reduced by 0.99 percentage points, from a low to medium density. The GDRbm (rate of grain dehydration before maturation) and the GDRam (rate of grain dehydration after maturation) showed an increasing trend from a low to medium density. From a medium to high density, the MCpm from the 1980s to 2000s could be significantly reduced by 1.78, 1.53 and 1.88 percentage points; the MCh from the 1980s could be significantly reduced by 1.77 percentage points; and the GDRbm from the 1970s was significantly increased by 0.101%/d, but the improvement of GDRam was not significant. With the planting density increase, the decreased ratios of relative GLAD (green leaf area duration) and leaf SPAD (soil and plant analyzer development) per plant of old maize hybrids were more than that of modern maize hybrids, which promoted the decrease in grain water content and the rate increase in grain dehydration for old maize hybrids. There was a direct positive correlation between the bract and grain dehydration rates, but the cob dehydration rate had no significant effect on the grain dehydration rate. With the increase in planting density, the relative GLAD and leaf SPAD values of plants decreased, and the stay-green of plants worsened, and a significant increase in the dehydration rate of bracts in old and modern eras was an important reason for the decrease in grain moisture content and increase in dehydration rate.
Exploring Knowledge of Antibiotic Use, Resistance, and Stewardship Programs among Pharmacy Technicians Serving in Ambulatory Care Settings in Pakistan and the Implications
Authors: Mustafa Zia Ul , Nazir Marriam , Majeed Hafiza Kiran , Salman Muhammad , Hayat Khezar , Khan Amer Hayat , Meyer Johanna C. , Godman Brian
Published: July 2022

Antimicrobial resistance (AMR) is a leading global health threat, increasing morbidity, mortality, and costs, with excessive and irrational use of antimicrobials contributing to the development of AMR. Consequently, the aims of this study were to evaluate the understanding of antibiotic use, AMR, and antimicrobial stewardship programs (ASPs) among pharmacy technicians serving in ambulatory healthcare settings in Pakistan. A cross-sectional survey was conducted among pharmacy technicians serving in 144 ambulatory care settings in seven districts of Punjab province using a validated questionnaire. Overall, 376 technicians completed the survey (85.8% response rate). The majority were men (89.1%), aged 25–35 years (45.1%), serving in emergency departments (43.9%) and filling 31–60 prescriptions per day (37.5%). Most (79.5%) knew that antibiotics were one of the most frequently prescribed drug classes, while 59.8% believed antibiotics for common colds did not speed up recovery. Inadequate duration (59.6%) and inadequate dosages (57.7%) of antibiotic therapy were reported as the leading causes of AMR. Terms including ‘superbugs’, ‘multidrug resistance’, and ‘extensively drug resistance’ were known to 42.0%, 25.3%, and 20.7% of participants, respectively; however, <10% knew about ASPs, including their core elements and purpose. Our study revealed that pharmacy technicians have adequate awareness of antibiotic use but are currently unaware of AMR and ASPs, which is a concern.
Protein Binding in Translational Antimicrobial Development-Focus on Interspecies Differences
Authors: Ahmed Hifza , Bergmann Felix , Zeitlinger Markus
Published: July 2022

Background/Introduction: Plasma protein binding (PPB) continues to be a key aspect of antibiotic development and clinical use. PPB is essential to understand several properties of drug candidates, including antimicrobial activity, drug-drug interaction, drug clearance, volume of distribution, and therapeutic index. Focus areas of the review: In this review, we discuss the basics of PPB, including the main drug binding proteins i.e., Albumin and α-1-acid glycoprotein (AAG). Furthermore, we present the effects of PPB on the antimicrobial activity of antibiotics and the current role of PPB in in vitro pharmacodynamic (PD) models of antibiotics. Moreover, the effect of PPB on the PK/PD of antibiotics has been discussed in this review. A key aspect of this paper is a concise evaluation of PPB between animal species (dog, rat, mouse, rabbit and monkey) and humans. Our statistical analysis of the data available in the literature suggests a significant difference between antibiotic binding in humans and that of dogs or mice, with the majority of measurements from the pre-clinical species falling within five-fold of the human plasma value. Conversely, no significant difference in binding was found between humans and rats, rabbits, or monkeys. This information may be helpful for drug researchers to select the most relevant animal species in which the metabolism of a compound can be studied for extrapolating the results to humans. Furthermore, state-of-the-art methods for determining PPB such as equilibrium dialysis, ultracentrifugation, microdialysis, gel filtration, chromatographic methods and fluorescence spectroscopy are highlighted with their advantages and disadvantages.
Valeriana pilosa Roots Essential Oil: Chemical Composition, Antioxidant Activities, and Molecular Docking Studies on Enzymes Involved in Redox Biological Processes
Authors: Minchán-Herrera Patricia , Ybañez-Julca Roberto O. , Quispe-Díaz Ivan M. , Venegas-Casanova Edmundo A. , Jara-Aguilar Rafael , Salas Felipe , Zevallos-Escobar Liz , Yáñez Osvaldo , Pino-Rios Ricardo , Calderon Pedro Buc , Benites Julio
Published: July 2022

Valeriana pilosa is usually employed in Peruvian folk medicine in the form of infusion to treat stomach pain, and has antispasmodic, relaxing, sleep-promoting, and sedative properties, as well as is an anti-inflammatory. In this study, Valeriana pilosa essential oil (VPEO) was obtained by hydrodistillation, analyzed by GC and GC/MS, and 47 compounds were identified. Major oil components were α-patchoulene (5.8%), α-humulene (6.1%), seychellene (7.6%), and patchoulol (20.8%). Furthermore, we assessed the in vitro antioxidant activities, molecular docking, and Ligand Efficiency studies on enzymes involved in cellular redox pathways such as CYP2C9, catalase, superoxide dismutase, and xanthine oxidase. Essential oil antioxidant activities were assessed by FRAP, ABTS•+, and DPPH• radical scavenging activity. VPEO displays high antioxidant activity as compared to essential oils of Valeriana jatamansi and Valeriana officinalis oil roots. In addition, molecular docking and ADMET prediction was employed to compare the absorption, metabolism, and toxicity properties of Valeriana pilosa compounds. In the molecular docking studies, limonene, p-cimene, carvone, α-cubebene, cyclosativene, α-guaiene, allo-aromadendrene, valencene, and eremophyllene were the compounds with the best docking score on CYP2C9 and xanthine oxidase. Thus, volatile components of Valeriana pilosa could be associated with the detected antioxidant activity, acting as putative inhibitors of CYP2C9 and xanthine oxidase.