bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Shape Accel Array for Deformation Monitoring and Parameter Inversion of a 300 m Ultrahigh Rockfill Dam
Authors: Ai Zhitao , Ma Gang , Zhang Guike , Cheng Xiang , Zou Quancheng , Zhou Wei
Published: July 2023

The global construction of rockfill dams has now surpassed the 300 m height level. Despite great achievements in dam design and construction, monitoring techniques have lagged behind the development of high rockfill dams. Existing deformation monitoring techniques are ill-suited to the high earth and water pressures, and extended monitoring periods are required for ultrahigh rockfill dams. This study introduces, for the first time, the use of a shape accel array (SAA) to monitor internal displacement in a 300 m high earth core rockfill dam. The SAA employs a rope-like array of capacitive MEMS accelerometers for deformation measurement. Compared to conventional monitoring techniques, SAA is a data-intensive monitoring technique. Based on the intensive data obtained from SAA, we employed a parameter inversion method, utilizing multiobjective optimization algorithm, the nondominated sorting genetic algorithm-III (NSGA-III), to inverse the constitutive model parameters of the rockfill dam. The multiobjective parameter inversion method maximizes the use of multisource monitoring data for predicting rockfill dam deformation.
ELISA Methods Based on Monoclonal Antibodies for the Serological Diagnosis of Lumpy Skin Disease
Authors: Baselli Stefano , Pezzoni Giulia , Sabino Marcella , Grazioli Santina , Wolff Janika , Hoffmann Bernd , Shtjefni Valentin , Capucci Lorenzo , Brocchi Emiliana
Published: July 2023

Lumpy skin disease (LSD) is a notifiable, transboundary cattle disease that spreads rapidly and has a relevant economic impact. The etiological agent is the LSD virus (LSDV), genus Capripoxvirus, and family Poxviridae. To date, LSDV is widely present in Africa, Asia, and in transcontinental regions like Russia, Turkey, and the Middle East, thus representing a continuous threat to free neighbours. Appropriate serosurveillance programs can complement disease control, inform about its spread, and enable the assessment of vaccination campaigns. Since reliable and practical diagnostic tools could improve serological surveillance, this study aimed to produce and characterize monoclonal antibodies (MAbs) that allowed us to develop ELISA tests for the serological detection of LSD. Four MAbs recognizing a 35 kDa viral protein were selected and used to develop and optimize competitive and indirect ELISAs. Both assays detected seroconversion within 14 days postinfection (dpi) in 18 cattle experimentally infected with LSDV and sequentially sampled for up to 4 weeks. The two novel ELISAs detected also antibodies raised by other capripoxviruses: as observed in cattle, both assays revealed seroconversion within 14 dpi in all nine sheep experimentally infected with sheeppox virus (SPPV), while in eight goats infected with goatpox virus (GTPV) competitive ELISA identified seropositivity earlier and in more animals compared to indirect ELISA. Overall, the sensitivity performance of both developed ELISAs resulted comparatively superior to those of virus neutralization test and the commercial Id.Vet ELISA. Testing of about 200 negative sera from each species recorded a single false-positive cattle in the indirect ELISA, which gave a specificity of 99.5%, whereas for the competitive ELISA, the diagnostic specificity was 100% irrespective of the species tested. The results enable concluding that both new tests correctly detect anti-LSDV antibodies in cattle and can also be reliable tools to recognize antibodies to SPPV and GTPV.
Predictors of Economics Students’ Behavioural Intention to Use Tablets: A Two-Staged Structural Equation Modelling–Artificial Neural Network Approach
Authors: Baba Yidana Mumuni , Arthur Francis , Winston Kaku Dominic , Anti Partey Peter
Published: July 2023

The government of Ghana, as part of its digitisation agenda, intends to provide all senior high school students in Ghana with tablets that are loaded with textbooks and other educational materials for their studies. This initiative is flaunted as one of the game-changing development that is yet to happen in the country. This study employed a modified unified theory of acceptance and use of technology model to examine Economics students’ behavioural intention to use tablets for learning. The study was quantitative research with a focus on a descriptive cross-sectional survey design. A total of 354 senior high school Economics students were selected for the study. A five-point Likert scale instrument was adapted as the data collection instrument for the study. A two-staged partial least square structural equation modelling–artificial neural network approach was used to analyse the data. The results revealed that effort expectancy, facilitating condition, social influence, and hedonic motivation had a significant positive influence on Economics students’ behavioural intention to use tablets for learning. However, habit and performance expectancy had no significant influence on Economics students’ behavioural intentions. Therefore, it was recommended that the implementation of the student-tablet policy should be hinged on social influence, effort expectancy, facilitating condition, and hedonic motivation (the student’s motivation) to use tablets due to internal satisfaction.
Table S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Authors: Kilian Michael , Friedrich Mirco , Sanghvi Khwab , Green Edward , Pusch Stefan , Kawauchi Daisuke , Löwer Martin , Sonner Jana K. , Krämer Christopher , Zaman Julia , Jung Stefanie , Breckwoldt Michael O. , Willimsky Gerald , Eichmüller Stefan B. , von Deimling Andreas , Wick Wolfgang , Sahm Felix , Platten Michael , Bunse Lukas
Published: July 2023

Table S2. Murine primers for evaluation of Cic expression.
Supplementary Tables 1-5 from Caveolin Gene Expression Predicts Clinical Outcomes for Early-Stage HER2-Negative Breast Cancer Treated with Paclitaxel-Based Chemotherapy in the GeparSepto Trial
Authors: Williams Terence M. , Schneeweiss Andreas , Jackisch Christian , Shen Changxian , Weber Karsten E. , Fasching Peter A. , Denkert Carsten , Furlanetto Jenny , Heinmöller Ernst , Schmatloch Sabine , Karn Thomas , Szeto Christopher W. , van Mackelenbergh Marion T. , Nekljudova Valentina , Stickeler Elmar , Soon-Shiong Patrick , Schem Christian , Mairinger Thomas , Müller Volkmar , Marme Frederik , Untch Michael , Loibl Sibylle
Published: July 2023

Supplementary Tables 1-5
Supplementary Table S1 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

ISH Probe Information
Supplementary Figure S6 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Subasumstat induces interferon-response genes in a dose responsive fashion
Supplementary Figure S3 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Subasumstatinduces IFNβ in immune cells.
Supplementary Figure S16 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Percentage of each of three macrophage populations in individual FOVS from Patient 8
Supplementary Figure S10 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Percentages of Cells identified by UMAP analysis from Tumors 7 and 8
Supplementary Figure 6 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer
Authors: Yaeger Rona , Mezzadra Riccardo , Sinopoli Jenna , Bian Yu , Marasco Michelangelo , Kaplun Esther , Gao Yijun , Zhao HuiYong , Paula Arnaud Da Cruz , Zhu Yingjie , Perez Almudena Chaves , Chadalavada Kalyani , Tse Edison , Chowdhry Sudhir , Bowker Sydney , Chang Qing , Qeriqi Besnik , Weigelt Britta , Nanjangud Gouri J. , Berger Michael F. , Der-Torossian Hirak , Anderes Kenna , Socci Nicholas D. , Shia Jinru , Riely Gregory J. , Murciano-Goroff Yonina R. , Li Bob T. , Christensen James G. , Reis-Filho Jorge S. , Solit David B. , de Stanchina Elisa , Lowe Scott W. , Rosen Neal , Misale Sandra
Published: July 2023

C106 resistant cells drug withdrawal and Patient #12 MSK-Impact data
Supplementary Figure 4 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer
Authors: Yaeger Rona , Mezzadra Riccardo , Sinopoli Jenna , Bian Yu , Marasco Michelangelo , Kaplun Esther , Gao Yijun , Zhao HuiYong , Paula Arnaud Da Cruz , Zhu Yingjie , Perez Almudena Chaves , Chadalavada Kalyani , Tse Edison , Chowdhry Sudhir , Bowker Sydney , Chang Qing , Qeriqi Besnik , Weigelt Britta , Nanjangud Gouri J. , Berger Michael F. , Der-Torossian Hirak , Anderes Kenna , Socci Nicholas D. , Shia Jinru , Riely Gregory J. , Murciano-Goroff Yonina R. , Li Bob T. , Christensen James G. , Reis-Filho Jorge S. , Solit David B. , de Stanchina Elisa , Lowe Scott W. , Rosen Neal , Misale Sandra
Published: July 2023

Generation of acquired resistance PDX model
Figure S6 from HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion
Authors: Toyoda Kosuke , Yasunaga Jun-ichirou , Shichijo Takafumi , Arima Yuichiro , Tsujita Kenichi , Tanaka Azusa , Salah Tarig , Zhang Wenyi , Hussein Osama , Sonoda Miyu , Watanabe Miho , Kurita Daisuke , Nakashima Kazutaka , Yamada Kyohei , Miyoshi Hiroaki , Ohshima Koichi , Matsuoka Masao
Published: July 2023

Efficacy of the MCT1/4 inhibitor syrosingopine on ATL cells.
Data from HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion
Authors: Toyoda Kosuke , Yasunaga Jun-ichirou , Shichijo Takafumi , Arima Yuichiro , Tsujita Kenichi , Tanaka Azusa , Salah Tarig , Zhang Wenyi , Hussein Osama , Sonoda Miyu , Watanabe Miho , Kurita Daisuke , Nakashima Kazutaka , Yamada Kyohei , Miyoshi Hiroaki , Ohshima Koichi , Matsuoka Masao
Published: July 2023

Abstract
Acceleration of glycolysis is a common trait of cancer. A key metabolite, lactate, is typically secreted from cancer cells because its accumulation is toxic. Here, we report that a viral oncogene, HTLV-1 bZIP factor (HBZ), bimodally upregulates TAp73 to promote lactate excretion from adult T-cell leukemia-lymphoma (ATL) cells. HBZ protein binds to EZH2 and reduces its occupancy of the TAp73 promoter. Meanwhile, HBZ RNA activates TAp73 transcription via the BATF3-IRF4 machinery. TAp73 upregulates the lactate transporters MCT1 and MCT4. Inactivation of TAp73 leads to intracellular accumulation of lactate, inducing cell death in ATL cells. Furthermore, TAp73 knockout diminishes the development of inflammation in HBZ-transgenic mice. An MCT1/4 inhibitor, syrosingopine, decreases the growth of ATL cells in vitro and in vivo. MCT1/4 expression is positively correlated with TAp73 in many cancers, and MCT1/4 upregulation is associated with dismal prognosis. Activation of the TAp73–MCT1/4 pathway could be a common mechanism contributing to cancer metabolism.
Significance:
An antisense gene encoded in HTLV-1, HBZ, reprograms lactate metabolism and epigenetic modification by inducing TAp73 in virus-positive leukemic cells. A positive correlation between TAp73 and its target genes is also observed in many other cancer cells, suggesting that this is a common mechanism for cellular oncogenesis.
Supplementary Table S2 from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
Authors: Pan Mengwu , Solozobova Valeria , Kuznik Nane C. , Jung Nicole , Gräßle Simone , Gourain Victor , Heneka Yvonne M. , Cramer von Clausbruch Christina A. , Fuhr Olaf , Munuganti Ravi S. N. , Maddalo Danilo , Blattner Christine , Neeb Antje , Sharp Adam , Cato Laura , Weiss Carsten , Jeselsohn Rinath M. , Orian-Rousseau Veronique , Bräse Stefan , Cato Andrew C. B.
Published: July 2023

Crystallographic data and structure refinement information for X15695, X15696 and X19168.
Data from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
Authors: Pan Mengwu , Solozobova Valeria , Kuznik Nane C. , Jung Nicole , Gräßle Simone , Gourain Victor , Heneka Yvonne M. , Cramer von Clausbruch Christina A. , Fuhr Olaf , Munuganti Ravi S. N. , Maddalo Danilo , Blattner Christine , Neeb Antje , Sharp Adam , Cato Laura , Weiss Carsten , Jeselsohn Rinath M. , Orian-Rousseau Veronique , Bräse Stefan , Cato Andrew C. B.
Published: July 2023

The pro-oncogenic activities of estrogen receptor alpha (ERα) drive breast cancer pathogenesis. Endocrine therapies that impair the production of estrogen or the action of the ERα are therefore used to prevent primary disease metastasis. Although recent successes with ERα degraders have been reported, there is still the need to develop further ERα antagonists with additional properties for breast cancer therapy. We have previously described a benzothiazole compound A4B17 that inhibits the proliferation of androgen receptor–positive prostate cancer cells by disrupting the interaction of the cochaperone BAG1 with the AR. A4B17 was also found to inhibit the proliferation of estrogen receptor—positive (ER+) breast cancer cells. Using a scaffold hopping approach, we report here a group of small molecules with imidazopyridine scaffolds that are more potent and efficacious than A4B17. The prototype molecule X15695 efficiently degraded ERα and attenuated estrogen-mediated target gene expression as well as transactivation by the AR. X15695 also disrupted key cellular protein–protein interactions such as BAG1–mortalin (GRP75) interaction as well as wild-type p53–mortalin or mutant p53–BAG2 interactions. These activities together reactivated p53 and resulted in cell-cycle block and the induction of apoptosis. When administered orally to in vivo tumor xenograft models, X15695 potently inhibited the growth of breast tumor cells but less efficiently the growth of prostate tumor cells. We therefore identify X15695 as an oral selective ER degrader and propose further development of this compound for therapy of ER+ breast cancers.
Significance:
An imidazopyridine that selectively degrades ERα and is orally bioavailable has been identified for the development of ER+ breast cancer therapeutics. This compound also activates wild-type p53 and disrupts the gain-of-function tumorigenic activity of mutant p53, resulting in cell-cycle arrest and the induction of apoptosis.
Data from A Pilot Study of Neoadjuvant Nivolumab, Ipilimumab, and Intralesional Oncolytic Virotherapy for HER2-negative Breast Cancer
Authors: Nguyen Vina P. , Campbell Katie M. , Nowicki Theodore S. , Elumalai Nila , Medina Egmidio , Baselga-Carretero Ignacio , DiNome Maggie L. , Chang Helena R. , Oseguera Denise K. , Ribas Antoni , Glaspy John A.
Published: July 2023

Purpose:
Neoadjuvant combination immune checkpoint blockade and intralesional oncolytic virotherapy have the potential to activate antitumor responses in patients with breast cancer.
Experimental Design:
Eligibility for this pilot phase I trial included patients with localized HER2-negative breast cancer who received systemic nivolumab and ipilimumab and intratumor talimogene laherparepvec (T-VEC; NCT04185311). The primary objective was to evaluate the safety and adverse event profile of immunotherapy combined with T-VEC in patients with localized, HER2-negative breast cancer.
Results:
Six patients were enrolled, 4 having relapses after prior neoadjuvant chemotherapy and 2 who were previously untreated. Toxicities included 1 patient having grade 3 hypotension and type 1 diabetes mellitus, 3 patients with hypothyroidism, and all patients having constitutional symptoms known to be associated with the administration of T-VEC. One patient had a pathologic complete response, 3 patients had pathologic partial responses, 1 showed no significant response, and 1 had disease progression. Biopsies demonstrated increased immune cell infiltration in samples from patients who responded to therapy.
Conclusions:
This triple immunotherapy regimen provided responses in patients with advanced or relapsed HER2-negative breast cancer, at the expense of long-term toxicities.
Significance:
Systemic immune checkpoint blockade with a programmed death receptor 1 and a CTL antigen-4 blocking antibody, combined with intralesional oncolytic virotherapy, is a chemotherapy-free combination aimed at inducing an antitumor immune response locally and systemic immunity.
Data from A pilot study of neoadjuvant nivolumab, ipilimumab and intralesional oncolytic virotherapy for HER2-negative breast cancer
Authors: Nguyen Vina P , Campbell Katie M. , Nowicki Theodore S , Elumalai Nila , Medina Egmidio , Baselga-Carretero Ignacio , DiNome Maggie L , Chang Helena R. , Oseguera Denise K , Ribas Antoni , Glaspy John A.
Published: July 2023

Abstract
Purpose: Neoadjuvant combination immune checkpoint blockade and intralesional oncolytic virotherapy have the potential to activate antitumor responses in patients with breast cancer.

Patients and Methods: Eligibility for this pilot phase 1 trial included patients with localized HER2-negative breast cancer who received systemic nivolumab and ipilimumab and intratumor talimogene laherparepvec (T-VEC) (NCT04185311). The primary objective was to evaluate the safety and adverse event profile of immunotherapy combined with T-VEC in patients with localized, HER2-negative breast cancer.

Results: Six patients were enrolled, four having relapses after prior neoadjuvant chemotherapy and two who were previously untreated. Toxicities included one patient having grade 3 hypotension and type 1 diabetes mellitus, three patients with hypothyroidism, and all patients having constitutional symptoms known to be associated with the administration of T-VEC. One patient had a pathological complete response, three patients had pathological partial responses, one showed no significant response, and one had disease progression. Biopsies demonstrated increased immune cell infiltration in samples from patients who responded to therapy.

Conclusions: This triple immunotherapy regimen provided responses in patients with advanced or relapsed HER2-negative breast cancer, at the expense of long-term toxicities.
Severe Clozapine Poisoning Treated by Extracorporeal Blood Purification Therapy
Authors: Hartjes Andreas , Machnik Matthaeus , Kubasta Christa , Schrattbauer Karl
Published: July 2023

Clozapine is a frequently used antipsychotic that, in case of overdose, can cause severe adverse side effects, such as hematological, cardiovascular, and neurological complications. As there is no specific antidote or reversal agent available, extracorporeal techniques such as CytoSorb hemoadsorption might represent a viable option, having already been used in a variety of intoxication scenarios with favorable rates of success. A 56-year-old male was admitted with generalized epileptic seizures and arrhythmias following ingestion of clozapine in a suicide attempt (5,000 mg). Subsequently, conventional supportive care was initiated. To accelerate drug removal, continuous veno-venous hemodiafiltration including the application of CytoSorb hemoadsorption therapy was started. Serial measurements confirmed rapid reduction of clozapine plasma levels. The patient remained hemodynamically stable throughout this period. Furthermore, there were no cardiac arrhythmias detected and liver values were normal. The patient improved and was successfully extubated 3 days after admission with good vigilance and no residual neurological abnormalities. This is the first clinical case report on the use of CytoSorb hemoadsorption in severe clozapine intoxication which helped quickly and efficiently reduce clozapine levels to nontoxic serum levels while preserving organ function. Therefore, CytoSorb might represent an alternative treatment modality to be considered for potentially lethal clozapine intoxications.
Recepção e compreensão de Luís de Camões no Japão
Authors: Watanabe Kazufumi
Published: July 2023

O artigo apresenta subsídios para refletir sobre a recepção de Luís de Camões no Japão. Na realização desse plano, o texto tece considerações acerca das traduções d’Os Lusíadas preparadas por Neves e Ota (1972), Ikegami, Kobayashi e Okamura (1978) e Ikegami (2000). Com isto em mente, o texto descreve as particularidades de cada versão, bem como os fins de cada livro. Na segunda parte do texto examina-se a repercussão da matéria camoniana a partir do caso específico de Manuel de Oliveira, cuja produção cinematográfica tem contribuído fortemente para a projeção do nome de Camões em terras japonesas.
A emulação camoniana em Prosopopeia: a Nova Lusitânia cantada em Os Lusíadas
Authors: Tofoli Barbara Faria , Leite Leni Ribeiro
Published: July 2023

Prosopopeia (1601), épica luso-brasileira de Bento Teixeira, foi por muito tempo lida como um mero simulacro camoniano, sem qualidades literárias próprias, devido às semelhanças com Os Lusíadas, de Camões. Neste artigo, busca-se confrontar essa perspectiva, mediante uma leitura do poema em que a emulação de Camões seja encarada como artifício retórico adotado por Bento Teixeira. Abordamos inicialmente a mímesis, que na Renascença se orientou pela imitação de autoridades consagradas pela tradição (SALTARELLI, 2009), para então destacar Camões como arquétipo do gênero épico em contexto lusitano. Bento Teixeira emula o modelo camoniano, ao elaborar Prosopopeia enquanto canto que Proteu deixou de pronunciar em Os Lusíadas, além de retratar os fidalgos da Nova Lusitânia, que, assim como os heróis antecessores, são assinalados na história como exempla dos valores reinóis lusos. Enquanto variação de Os Lusíadas, Prosopopeia apresenta diversas semelhanças e disparidades em relação à épica camoniana, como as analogias mitológicas, a temática das Grandes Navegações e as ekphraseis de Tritão. Essas associações – que ora se aproximam, ora se distanciam – são elencadas ao longo do artigo, a fim de evidenciar o diálogo entre as épicas, assim como a relevância de Prosopopeia para a camonologia.
Safety and Tolerability of Direct Ischemic Postconditioning Following Thrombectomy for Acute Ischemic Stroke
Authors: Wu Longfei , Wei Ming , Zhang Bohao , Zhang Bowei , Chen Jian , Wang Sifei , Luo Leilei , Liu Shuling , Li Sijie , Ren Changhong , Hess David C. , Song Haiqing , Zhao Wenbo , Ji Xunming
Published: July 2023

BACKGROUND:

Experimental studies have demonstrated the neuroprotection of ischemic postconditioning (IPostC) in acute ischemic stroke by attenuating ischemia-reperfusion injury. This study aimed to investigate the safety and tolerability of direct IPostC in both a dog model and patients with acute ischemic stroke treated with thrombectomy.

METHODS:

The study involved 2 parts. First, IPostC was induced by repeated balloon inflation and deflation in dogs, where a low-pressure balloon was navigated to the anterior spinal artery, and 4 cycles of 5-minute ischemia followed by 5-minute reperfusion were performed. Vascular injuries were assessed using angiography and vascular tissue specimens. Then, a 3+3 dose-escalation trial was conducted in patients with acute ischemic stroke following successful thrombectomy recanalization. Patients received direct IPostC with ischemia and reperfusion durations in progressive increments of 0, 1, 2, 3, 4, and 5 minutes ×4 cycles. Major adverse responses were defined as vessel perforation, rupture, dissection, reocclusion, severe vasospasm, thrombotic events, and rupture of the balloon.

RESULTS:

IPostC was investigated in 4 dogs. No vessel perforation or rupture, dissection, or vasospasm was observed under the angiography. Only 1 vessel experienced mild injury between the intima and the internal elastic membrane detected on a histopathologic slide. Then, 18 patients were recruited. The duration of IPostC was progressively escalated with no major response happened. No patient experienced agitation, discomfort, or other tolerability issues. Five patients (27.8%) experienced any intracranial hemorrhage after thrombectomy, and 1 (5.6%) was symptomatic. At 3-month follow-up, no patient died, and 9 patients (50%) achieved functional independence.

CONCLUSIONS:

Direct IPostC inducing by 4 cycles of 5-minute ischemia followed by 5-minute reperfusion is safe, feasible, and tolerable in patients with acute ischemic stroke treated with thrombectomy. Further investigations are needed to determine the safety and preliminary efficacy of direct IPostC.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT05153655.
Leafhopper subfamily Hylicinae (Hemiptera: Auchenorrhyncha: Cicadellidae) in the Indian subcontinent with description of new species
Authors: VIRAKTAMATH C. A. , YESHWANTH H.M.
Published: July 2023

The genera and species of Hylicinae reported from the Indian subcontinent are reviewed. Hatigoria zhangi sp. nov. (India: Arunachal Pradesh), Hemisudra indica sp. nov. (India: Manipur), Kalasha confusa sp. nov. (India: Meghalaya), Kalasha manikya sp. nov. (India: Manipur) and Sudra manipurensis sp. nov. (India: Manipur) are described. Genera Hemisudra Schmidt, Hatigoria Distant and Sudra Stål are new records for India. All the taxa dealt with are illustrated and diagnosed, new taxa are described and illustrated. A revised diagnosis of the subfamily Hylicinae is provided. A revised key to Hylicinae genera of the Indian subcontinent and a checklist are also provided.
Assessing Vulnerability and Population Exposed to Drought in Various Climatic Regions of Northeastern Iran
Authors: Zarei Mahdi , Hosseini Seyyed Hadi , Naemitabar Mahnaz
Published: July 2023

The motivations of this research are the continuation and intensification of drought effects on various socioeconomic sectors and the observation of few studies and no coordinated efforts to provide a compatible framework for drought risk management in different economic sectors and population groups of the study region. Present research was carried out to assess the vulnerability and population exposed to drought in Khorasan Razavi Province. Meteorological datasets for the years 1950–2020; drought indices including self-calibrating Palmer (scPDSI), standardized precipitation (SPI), and standardized precipitation evapotranspiration (SPEI); population and livestock density indicators; agricultural lands; water stress; and socioeconomic and infrastructural factors have been used. Results indicate that dry and wet periods were estimated to be more intense by SPEI in all studied stations; also, a significant difference was observed between the results of the SPI and SPEI indices in determining the long dry and wet periods. The highest variation between the occurrence of dry and wet periods was estimated using SPEI, which could be related to seasonal fluctuations of temperature and computational evapotranspiration. Although no significant correlation was observed between used indices to identify the number of wet months, a significant positive correlation exists between the numbers of dry months estimated by those. Drought risk analysis demonstrated that the central and southern parts of the province are exposed to very severe drought while the northern and northeastern parts of the area are more inclined to severe drought. The highest class of drought exposure is observed in the southern, central, and eastern regions of the province, so they represent the high-risk category of drought.
Combination of the Ratio Between Negative and Harvested Lymph Nodes and Metastatic Lymph Node Count as a Prognostic Indicator in Stage III Colon Cancer: A Retrospective Cohort Study
Authors: Benli Sami , Tazeoğlu Deniz , Çolak Tahsin
Published: July 2023

Background

This study aimed to investigate the relationship between the ratio of negative lymph nodes (NLN) number to the number of metastatic lymph nodes (MLN) and the harvested lymph nodes (HLN) number ratio survival rate and compare its prognostic value.

Methods

This retrospective cohort study included 207 stage III colon cancer patients between 2010 and 2018 at a single center. NLN/MLN and NLN/HLN cut-off values were determined with the receiver operating characteristic (ROC) curve according to 5-year survival. The patients were divided into high-risk and low-risk groups according to the cut-off value. These 2 groups were evaluated according to the clinicopathological data of the patients.

Result

The time-dependent ROC curve showed the optimal cut-off values of NLN as 3.86 and .79, respectively. These values show 83 patients in the high-risk group and 124 in the low-risk group. There was no difference between the groups in tumor localization and T stage. According to Kaplan-Meier survival analysis, mean survival was 35.88 months in the high-risk group and 50.18 months in the low-risk group. The risk of death in the high-risk group was 305% compared to the low-risk group (Hazard Ratio: 3.05, 95% 1.91 – 4.88) ( P < .001).

Conclusion

NLNs are among the critical prognostic factors in colon cancer. Although NLNs have a positive correlation with the survival rate of the patients, there is no statistical difference in tumor T stage and localization.
Acute Effects of Systemic Glucocorticoids on the Vocal Folds in a Pre-Clinical Model
Authors: Gartling Gary , Nakamura Ryosuke , Sayce Lea , Kimball Emily E. , Wilson Azure , Schneeberger Steven , Zimmerman Zachary , Garabedian Michael J. , Branski Ryan C. , Rousseau Bernard
Published: July 2023

Objectives/Hypothesis:

Systemic glucocorticoids (GC)s are employed to treat various voice disorders. However, GCs have varying pharmacodynamic properties with adverse effects ranging from changes in epithelial integrity, skeletal muscle catabolism, and altered body weight. We sought to characterize the acute temporal effects of systemic dexamethasone and methylprednisolone on vocal fold (VF) epithelial glucocorticoid receptor (GR) nuclear translocation, epithelial tight junction (ZO-1) expression, thyroarytenoid (TA) muscle fiber morphology, and body weight using an established pre-clinical model. We hypothesized dexamethasone and methylprednisolone will elicit changes in VF epithelial GR nuclear translocation, epithelial ZO-1 expression, TA muscle morphology, and body weight compared to placebo-treated controls.

Methods:

Forty-five New Zealand white rabbits received intramuscular injections of methylprednisolone (4.5 mg; n = 15), dexamethasone (450 µg; n = 15), or volume matched saline ( n = 15) into the iliocostalis/longissimus muscle for 6 consecutive days. Vocal folds from 5 rabbits from each treatment group were harvested at 1-, 3-, or 7 days following the final injection and subjected to immunohistochemistry for ZO-1 and GR as well as TA muscle fiber cross-sectional area (CSA) measures.

Results:

Dexamethasone increased epithelial GR nuclear translocation and ZO-1 expression 1-day following injections compared to methylprednisolone ( P = .024; P = .012). Dexamethasone and methylprednisolone increased TA CSA 1-day following injections ( P = .011). Methylprednisolone decreased body weight 7 days following injections compared to controls ( P = .004).

Conclusions:

Systemic dexamethasone may more efficiently activate GR in the VF epithelium with a lower risk of body weight loss, suggesting a role for more refined approaches to GC selection for laryngeal pathology.
Show and Tell: Photography and Storytelling to Better Understand the End-of-Life Experience of Families in the Intensive Care Unit
Authors: Binette Emilee , Elwell Joy , Parekh de Campos Amisha , Anderson Robert V.
Published: July 2023

End-of-life in the Intensive Care Unit (ICU) is common, costly, and can contribute to negative health outcomes for bereaved family members. Insufficient understanding of the family experience results in poor quality, highly variable care riddled with deficiencies including effective identification and application of evidence-based clinical interventions. Successfully managing the multitude of transitions, for example changes in family role or personal identity requires creative practice guided by theory. This project supports the feasibility of using peri-mortem photographs captured by family members with story-telling and a standardized measurement of grief to explore the family experience of end-of-life in the ICU. Project findings reveal shared experiential themes and emphasize the value of photography and storytelling as meaning-making interventions for families. Further study to generalize findings and develop additional preventative and therapeutic interventions at and beyond end-of-life in the ICU is needed to better meet family needs and improve their health outcomes.
A Loss by Suicide: The Relationship Between Meaning-Making, Post-Traumatic Growth, and Complicated Grief
Authors: Delgado Heather , Goergen Jessica , Tyler Jessica , Windham Heather
Published: July 2023

Meaning making has been found useful in processing grief, yet individuals who have experienced a loss by suicide may have difficulty with post-loss adjustment due to the traumatic nature of their loss. Through quantitative study, this article acts as an initial exploratory study and examines the relationship between meaning-making, post-traumatic growth, and complicated grief symptoms in 81 college students from a large university in the United States who have experienced the loss of a loved one to suicide. The results of this study indicated that meaning-making serves as a mediator in the relationship with post-traumatic growth and complicated grief. This finding sheds light on the importance of meaning-making as a possible avenue of interventions for clinical use in bereavement from loss by suicide to treat grief symptoms and lead to post-traumatic growth.
Comparison of Frequentist and Bayesian Statistics for Studying Unconscious Perception: Differences Between Null Awareness Dissociation and Relative Sensitivity Dissociation
Authors: Fisk Gary D. , Haase Steven J.
Published: July 2023

For unconscious perception research, Bayesian statistics are more appropriate for assessing null awareness of masked stimuli than traditional (frequentist) statistics. This assertion is based mostly upon the theoretical features of Bayesian statistics and modeling studies. To further assess the potential advantages, we compared frequentist and Bayesian statistical tests in a masked Stroop priming experiment in which the prime stimuli were presented at varying degrees of visibility. A novel contribution was to compare a null awareness dissociation approach (i.e., stimulus awareness = 0) to a relative sensitivity approach (indirect or priming effects > direct effects) for the same data. From a null awareness perspective, the frequentist t-tests for the Stroop effect (i.e., perception) for the briefest display conditions had non-significant outcomes. Similar Bayesian t-tests were inconclusive. In contrast, the relative sensitivity dissociation approach was more interpretable, with strong evidence against unconscious perception from a single Bayesian t test. For the longer display conditions, both statistical approaches suggested large conscious perception effects. We conclude that the utility of Bayesian statistics is highly dependent upon the type of dissociation approach, with a relative sensitivity approach being more straightforward to interpret than a null awareness approach.
New Opportunities for Japanese Universities to Internationalize Communication Courses
Authors: Fujio Misa
Published: July 2023

Due to the economic sluggishness seen in Japan over the past few decades and the shrinking inward investment market, the Japanese government has introduced educational reforms in order to foster “global human resources” able to compete with overseas talent. One key area of emphasis has been communication education with a special focus on English. In this article, after reviewing the government’s reform plans, the author will analyze (1) how Japanese universities have incorporated these policies into their organizations, with an emphasis on the country’s internationally top-rated universities, and (2) how individual instructors have modified them for their own classes, with reference to a specific case of a successful partnership with an overseas university. Based on the analyses, future opportunities for communication studies will be highlighted in “Discussion” section, including stronger and more flexible ties with overseas universities, in particular among the Asia-Pacific Region, and how a country of non-native speakers of English could show initiative in developing collaborations with overseas universities.
Informal employment and irregular migration status: A double whammy for migrant workers in Thailand
Authors: Ducanes Geoffrey M , Engblom Anna , Ramos Vincent Jerald R
Published: July 2023

While a thick strand of literature demonstrates informally employed workers and irregular migrants being generally worse off in the labor market, little has been done to examine and compare these two sources of disadvantages. Using regression analyses on a survey of migrant workers in Thailand from Cambodia, Myanmar and Lao People’s Democratic Republic, the paper measures the prevalence of informal employment and estimates the differential contributions of irregular migration status and informal employment on various employment conditions. The paper finds that informality has a relatively stronger association with worse employment conditions, and systematic differences persist across sectors of employment and countries of origin. Initiatives to improve working conditions for irregular migrant workers should thus focus on both formalizing their employment status and expanding access to legal and safe migration, including social protection programs, in destination countries.
Risk Factors for Severe Clinical Course in Epistaxis Patients
Authors: Hadar Ayalon , Shaul Chanan , Ghantous Jameel , Tarnovsky Yehuda , Cohen Adiel , Zini Avraham , Peleg Uri
Published: July 2023

Purpose: Epistaxis is a common medical emergency that may require admission to the emergency department (ED) and treatment by an otolaryngologist. Currently, there are no widely accepted indications for hospitalization, and the decision is based on personal experience. Methods: A retrospective study of 1171 medical records of patients with epistaxis treated at our tertiary medical center ED from 2013 to 2018 with no age limit. The presence of recurrent epistaxis, a posterior source of bleeding, the need for hospitalization, the need for blood transfusion, or surgical intervention defined severe clinical course. Results: The 1171 admissions included 230 recurrent admissions for a total of 941 patients (60% males) who were treated by an otolaryngologist. The average age was 57.6 in the adult population (>15) and 6.6 in the pediatric population (≤15). Of all patients, 39% had hypertension; 39% took antiplatelet/anticoagulation therapy; 63% came during winter—a significant risk factor; 34 (2.9%) had reduced hemoglobin levels of >1gr%, but only 7 received a blood transfusion; 131 (11%) were hospitalized, and 21 (1.8%) required surgical control of the bleeding. Age (OR 1.02; CI 1.01-1.023), male sex (OR 2.07; CI 1.59-2.69), hypertension (OR 1.76; CI 1.27-2.45), and antiplatelet/anticoagulation therapy (OR 2.53; CI 1.93–3.33, OR 1.65; CI 1.11–2.44, respectively), were significantly correlated with severe clinical course. Conclusion: Epistaxis is significantly more common and severe in older male patients with hypertension or antiplatelet/anticoagulation therapy. However, few need a blood transfusion or surgical intervention. In borderline cases with no definitive indication for hospitalization, we suggest adopting these factors as indications for hospitalization due to their marked influence on the clinical course. Routine coagulation tests are indicated in patients treated with warfarin or combined antiplatelet + anticoagulation therapy.
At Risk of Statelessness: Children Born in Lebanon to Migrant Domestic Workers
Authors: Fernandez Bina , McGee Thomas , Albarazi Zahra , Brennan Deirdre , Block Karen
Published: July 2023

Lebanon has many migrant domestic workers, most of whom are women. While migrant domestic workers’ contracts prohibit pregnancy and childbearing, a substantial number of women give birth in Lebanon, and their children are at risk of statelessness. Through our examination of nationality laws and birth registration regulations, and their implementation in both Lebanon and migrants’ origin countries, this article offers an intersectional, gender analysis of conditions contributing to the risks of statelessness for such children. It seeks to contribute new insights into a seemingly intractable problem in Lebanon. Our investigation of laws and regulations is situated within a discussion of Lebanon's kafala system of migrant sponsorship that structures conditions under which migrant workers live. We triangulate our analysis by drawing on 13 semistructured interviews with key informants in Lebanon. We demonstrate that the risk of statelessness for children born to migrant domestic workers in Lebanon is enmeshed in a complex gendered and racialized conjunction of controls exercised over migrant domestic workers’ reproductive capacity, mobility, migration status, and right to pass on their nationality to their children. Based on this analysis, we identify potential strategies to secure citizenship for migrant domestic workers’ children at risk of statelessness. Our article makes analytical and empirical contributions to an emergent body of scholarship focusing on the growing phenomenon of childhood statelessness in “irregularized” migration contexts.
Parliamentary candidates and their campaign messages at the 2019 General Election
Authors: Trumm Siim , Milazzo Caitlin , Duggan Alan
Published: July 2023

The 2019 General Election brought about a significant change in the parliamentary balance of power. There has already been much attention devoted to how parties and their leaders campaigned in the run up to the polling day. Using original leaflet data from the OpenElections project, this study extends the focus to individual candidates by exploring the nature of local campaign communications. We find that candidates make little effort to promote their personal traits, with personalisation of leaflets remaining largely limited to offering visual cues in the shape of candidate photos. We also find that while negative campaign messages are common, they tend to relate to an opposing party more generally. Similarly, we find that highlighting the tactical situation in the constituency remains a rare practice. Our findings suggest that there is still considerable room for candidates to tailor their campaign materials to their personal attributes and the local electoral context.
Late-stage esophageal neuroendocrine carcinoma in a patient treated with tislelizumab combined with anlotinib: a case report
Authors: Zhang Yanqi , Liu Xiaoyu , Liang Honglu , Liu Weihua , Wang Haiyan , Li Tao
Published: July 2023

Esophageal neuroendocrine carcinoma (ENEC) is an extremely rare tumor with highly malignant potential, rapid growth, and a poor prognosis. Advanced extrapulmonary neuroendocrine carcinoma should be treated with chemotherapeutic regimens suitable for small cell lung cancer. However, ENEC has no clear second-line treatment options. The clinical application of immunotherapy and targeted therapy in small cell lung cancer has produced good therapeutic effects. We describe the case of an elderly woman with multiple metastatic advanced ENEC treated with tislelizumab combined with anlotinib as second-line therapy, achieving complete remission in a short period and long-term survival. In total, 21 cycles of tislelizumab combined with anlotinib were given to this patient. After two cycles, the patient’s neuron-specific enolase level decreased from 181.8 to 22.9 µg/L and remained at normal levels throughout treatment. Progression-free survival and overall survival were 16 and 21 months, respectively, in this patient. No obvious side effects were observed. Thus, tislelizumab and anlotinib could represent a novel therapeutic option for advanced ENEC.
Biofortification in Ethiopia: Opportunities and Challenges
Authors: Bachewe Fantu , Genye Tirsit , Girma Meron , Samuel Aregash , Warner James , van Zyl Cornelia
Published: July 2023

Background:

Children younger than 5 years and women of reproductive age often suffer from micronutrient deficiencies. Biofortification, which involves enriching staple crops with micronutrients, is a nutritional intervention focused on addressing micronutrient deficiencies. It is equitable, sustainable, and costs less than other nutritional interventions.

Objective:

This study investigates biofortification in Ethiopia, considering 6 globally biofortified crops, 5 of which are currently being biofortified in Ethiopia. However, only 2 of these crops are important in the consumption baskets of most Ethiopians. Therefore, efforts to mainstream biofortification should begin with studies to identify crops that have larger impacts in reducing local micronutrient deficiencies and their cost-effectiveness.

Methods:

Literature was searched between July and December 2021 using Google Scholar to provide insights into the state of biofortification in Ethiopia. Key-informant interviews were conducted to gain insights into the state of biofortification in Ethiopia and to identify bottlenecks for scaling up the production and consumption of biofortified foods. Furthermore, Annual Agriculture Sample Survey and 2015/16 Ethiopian Household Consumption and Expenditure Survey data were used to describe the area under production of biofortifiable crops and their importance in total consumption, respectively.

Results:

Mainstreaming biofortification in Ethiopia faces several challenges. Policy documents appear to be inconsistent, regressive, and vague regarding biofortification. Critically, there is no specific institution to oversee and/or coordinate biofortification-related activities.

Conclusion:

Overall, the success of biofortification depends upon a strong coordination body with clear mandates from detailed policies; adequate funding for research and development; and robust monitoring and evaluation of the identified production, adoption, and consumption issues.