bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidermal growth factor receptor (EGFR) mutations in the serum of non–small cell lung cancer (NSCLC) patients as a marker to select patients for targeted therapy
Authors: Mohan Anant , Ansari Ashraf , Masroor Mirza , Saxena Alpana , Pandey Ravinder. M. , Upadhyay Ashish , Luthra Kalpana , Khilnani Gopi. C , Jain Deepali , Kumar Rakesh , Guleria Randeep
Published: January 2025

Background:

The utility of serum as a specimen for epidermal growth factor receptor (EGFR) mutation detection and to select patients most likely to benefit from tyrosine kinase inhibitor (TKI) therapy is unclear.

Methods:

EGFR mutations (exons 19, 20, 21) were determined in the serum (n = 247) and tissue (n = 170) of treatment-naïve adenocarcinoma patients using allele-specific polymerase chain reaction (AS-PCR) technique. The prognostic value of EGFR in serum was evaluated following treatment based on overall survival (OS) and progression-free survival (PFS).

Results:

EGFR mutations in exon 19 and/or exon 21 were detected in 79/247 (31.9%) patients in serum and 52/170 (30.6%) patients in tissue. The presence of EGFR mutations in serum or tissue was significantly associated with OS, and the presence of EGFR mutations in serum, but not in tissue, showed a significant association with longer PFS. In patients who received gefitinib, those who were mutation positive in tissue or serum had a significantly better OS and PFS compared with mutation-negative patients. The OS and PFS of patients with detectable EGFR mutations both in serum and in tissue were significantly better than in patients without mutations in either specimen. Patients with mutations in both serum and tissue had a 70% lower risk of overall mortality and 46% lower risk of disease progression compared to patients with mutations only in tissue but not in the serum.

Conclusion:

Serum EGFR detection demonstrates good prognostic value for the response after treatment in advanced non–small cell lung cancer and may be a promising specimen for liquid biopsy for selecting patients most likely to benefit from TKI therapy.
Worst pattern of invasion in oral squamous cell carcinomas: Assessing the prognosis of malignancy from its invasive front
Authors: Jadhav Toyaja M. , Malik Ajay , Shelly Divya , Kashif Ahmed Waheed , Sahu Rajesh , Gupta Samir , Tyagi Arvind K.
Published: January 2025

Background:

Oral squamous cell carcinoma (OSCC) is one of the commonest malignancies worldwide and in India. Its prognosis can be determined by various clinicopathological parameters, an important one being the worst pattern of invasion (WPOI). The present study was undertaken to assess the prognostic value of WPOI and its correlation with other prognostic parameters in determining the outcome of OSCC, correlation of these parameters with the clinical outcome, and to verify the histological risk assessment score (HRS) proposed by Brandwein-Gensler et al. in 2005.

Methods and Material:

In this retrospective descriptive study, 194 cases of OSCC were evaluated with at least two years of follow-up data, histopathologically for their WPOI, depth of invasion (DOI), perineural invasion (PNI), lymphovascular invasion (LVI), and lymph node metastasis with extranodal extension along with clinical outcome in the form of locoregional recurrence (LRR) and disease-specific survival (DSS). Cases were also categorized as high risk, intermediate risk, and low risk based on their WPOI and the HRS. These features were statistically correlated with WPOI and compared with the patient clinical outcome.

Results:

Statistically significant association was noted between WPOI and sex, histological grade, tumor and nodal stage, DOI and site of recurrence. Although no statistically significant correlation was seen between WPOI and the clinical outcomes, WPOI showed a statistically significant correlation with HRS. Also, HRS showed a significant correlation with DSS.

Conclusions:

WPOI, histological grade, DOI, LHR, PNI, LVI and tumor and nodal stage can be entrusted to assess the prognosis of OSCC. Of these, WPOI is the single most reliable marker for assessing the HRS-based risk status of OSCC. This study validates the HRS proposed by Brandwein-Gensler et al.
Tumor budding in invasive breast carcinoma of no special type and its correlation with known histopathological prognostic factors: A retrospective study
Authors: Radhakrishnan N , Mathews A , Bhargavan R , Raghavan RK , George PS , Kattoor J
Published: January 2025

Context:

Tumor budding (TB) has been extensively studied and proposed as an independent prognostic factor in carcinoma colon. The International Tumor Budding Consensus Conference (ITBCC) suggested strict criteria for the classification and grading of tumor buds.

Aims:

Our study aims to grade tumor buds according to the ITBCC criteria and assess its association with the known histomorphological prognostic factors in invasive breast carcinoma of no special type.

Methods:

In this retrospective study, 122 cases from January 1, 2019, to June 30, 2019, were assessed. Intratumoral and peritumoral buds were graded as Grades 1, 2, or 3. The correlation of each grade of TB with tumor morphology patterns and known histological prognostic features was statistically assessed. A P value < 0.05 was taken as significant.

Results:

Grade 3 TB had a significant association with lymphovascular emboli, infiltrative tumor borders, desmoplastic/sclerotic tumor stroma, poorly differentiated carcinoma clusters, perineural invasion, lobular pattern of morphology, estrogen receptor and progesterone receptor positive status (P < 0.05). Peritumoral budding Grades 2 and 3 together had a significant correlation with lymph node metastasis. On multivariate analysis, infiltrative tumor margins and intratumoral budding had a significant association with lymphovascular emboli independent of all the other poor prognostic factors.

Conclusions:

TB in breast can be graded according to the ITBCC criteria suggested for the colon. A higher grade of TB has a significant correlation with the metastatic potential (lymphovascular emboli and lymph node metastasis) and can be included as an independent prognostic marker of breast cancer as seen in our study.
Evaluation of serum vascular cell adhesion marker-1 in β- thalassemia major patients
Authors: Al-Sarai Nuha Abd Ali , Al-Mudallal Subh Salim , Najm Rana Rai’d
Published: January 2025

BACKGROUND:

Defects in the production of one or more hemoglobin chains result in a set of hereditary hematologic illnesses known as thalassemias. Alpha and β-thalassemia are the two primary thalassemia classifications. The pathophysiology of β-thalassemia is significantly influenced by endothelial activation markers, such as vascular cell adhesion molecule 1 (VCAM-1), which have been found to be higher in both transfusion-dependent and nontransfusion-dependent thalassemia patients. These markers have been suggested for the follow-up of vascular disease in this patient group.

OBJECTIVES:

The aim of this study was to evaluate the level of soluble VCAM-1 in β-thalassemia major patients and to correlate its level with the clinical parameters.

PATIENTS, MATERIALS AND METHODS:

This case–control study was enrolled on 40 patients with β-thalassemia major. They were collected from Thalassemia Center of Babylon Maternity and Pediatrics Teaching Hospital, from December 28, 2022, to March 30, 2023. Twenty of them were splenectomized, others were not. Another 40 apparently healthy individuals with no family history of thalassemia or other hemoglobinopathy were enrolled in this study as controls. The samples were collected to assay the human VCAM-1 using enzyme-linked immunosorbent assay based on the biotin double antibody sandwich technology.

RESULTS:

Among 80 subjects, age and body mass index were similar across groups. There are differences in complete blood count (CBC) parameters between thalassemic and control groups. Thalassemic patients displayed notably higher levels of VCAM-1 and ferritin compared to controls and in splenectomized patients than nonsplenectomized patients. There is a high significant correlation exists between VCAM-1 and ferritin, VCAM-1 and various CBC parameters.

CONCLUSIONS:

There are higher levels of VCAM-1 in β-thalassemia major patients compared to the control and in splenectomized compared to non-splenectomized patients which usually associated with disease complications, furthermore it reflect endothelial activation and dysfunction.
Nasopharyngeal carcinoma presenting as lip numbness: a case report
Authors: Abd. Nasir Wan Nor Amira Wan Ahmad , Shing Sandra Ling Soon , Wei Lee Sie , Tatt Lim Woei , Kiong Shim Chen
Published: January 2025

Paresthesia is defined as a morbid, perverted, abnormal sensation such as burning, prickling or formication. Lip paresthesia can be either acute or chronic depending on the underlying condition. In cases of unilateral lip paresthesia, cranial nerves may be affected by regional causes. We present here a case of a 58-year-old Chinese gentleman complaining of left upper lip numbness. The numbness is concurrent to the left infraorbital and frontal area followed by pain. Nasoendoscopy by the Otorhinolaryngology team found abnormal growth in both left and right Fossa of Rosenmüller. Biopsies taken confirmed that they were non-keratinizing squamous cell carcinoma. A final diagnosis of nasopharyngeal tumour (NPC) (T4N2M0) was made. This case illustrates upper lip paresthesia as a possible presentation of NPC. A prompt referral to the appropriate speciality is needed by dental clinicians for further management in cases such as this.
Intraoral myoepithelial carcinoma of a 5-month-old infant – A Case Report
Authors: Vuan Wong Ling , Siew Han Fong , Abidin Marzuki Zainal , Ismail Siti Mazlipah , Choon Kok Tuck
Published: January 2025

Intraoral myoepithelial carcinoma is a rare disease. It can be frequently misdiagnosed as other benign salivary gland tumours. This article reports a case of a 5- month-old infant girl who presented with a rapidly enlarging left cheek and palatal swelling. Computerized tomography revealed the presence of a large expansile, lytic bony lesion in left hard palate. Histopathological diagnosis of myoepithelial carcinoma was made through a biopsy. Neoadjuvant chemotherapy was delivered prior to surgical resection. Reconstructive surgery was deferred until adulthood when the maxilla and mandible have ceased growing. Strict regular follow-up after surgery was prescribed. Patient was disease free four years post surgery with symmetrical face, minimal left infraorbital depression and inconspicuous scar. Total clearance of tumour remains the main treatment of intraoral myoepithelial carcinoma. A good outcome was achieved through a team approach.
A rare case of Desmoplastic Fibroma of the mandible and masticatory muscles
Authors: Murray Sophia Ann Murray Jeffry , Bustaman Ahmad Fahmi Mohamad , Zainal Sharifah Azlin Juliana Syed , Abraham Mannil Thomas , Yusoff Mohd Nury
Published: January 2025

Desmoplastic Fibroma is a rare, slowly progressive, and aggressive benign bone tumour. It is made up of spindle cells with minimal atypia and abundant collagen production. It occurs most commonly in the mandible, followed by the femur and pelvis. However, because it is so rare and presents differently with each patient, the diagnosis and management of these lesions still varies from case to case. We present a case of an otherwise healthy Malaysian Air Force officer who presented with left facial swelling accompanied by severe pain and trismus. Patient was thought to have osteomyelitis of the left mandible based on clinical and radiological findings. However, despite multiple debridement, IV antibiotic therapies, incisional biopsies and radiological investigations, patient's symptoms persisted. Finally, after 4 years, we landed on a provisional diagnosis of Desmoplastic Fibroma of the mandible bone and the adjacent muscles of mastication. We hope to highlight our experience in the management of this case so it will aid in the betterment of approach in such cases in the future.
Trauma-Induced Facial Nerve Paralysis & Their Management (Part I)
Authors: Tang Liszen , Ngeow Wei Cheong , Lo Sue Ann , Gan Pei San
Published: January 2025

The facial nerve is the 7th Cranial Nerve (CN VII) that innervates the muscles of facial expression. It is a mixed nerve that contains motor, sensory, and parasympathetic fibres. Trauma is a distant second to idiopathic or Bell's palsy as the cause of facial nerve paralysis. Paralysis of this nerve can occur during childbirth, or as a result of head trauma, and rarely, as a result of scuba diving barotrauma and lightning. Part I of this narrative review provides an overview on the types of trauma-induced facial nerve paralysis based on its aetiology, and an update on the currently used classification systems that categorises the severity of nerve palsy.
The eighth moment of the Riemann zeta function
Authors: Ng Nathan , Shen Quanli , Wong Peng-Jie
Published: January 2025

We establish an asymptotic formula for the eighth moment of the Riemann zeta function, assuming the Riemann hypothesis and a quaternary additive divisor conjecture. This builds on the work of the first author on the sixth moment of the Riemann zeta function and the works of Conrey–Gonek and Ivić. A key input is a sharp bound for a certain shifted moment of the Riemann zeta function, assuming the Riemann hypothesis.
Кратные тригонометрические ряды с частично монотонными коэффициентами
Authors: Dzhumabaeva Dzhamilya Gumarovna , Dyachenko Mikhail Ivanovich , Nursultanov Erlan Dautbekovich
Published: January 2025

Рассматривается вопрос о справедливости аналогов теоремы Харди-Литтлвуда для тригонометрических рядов с частично монотонными коэффициентами.
Библиография: 8 названий.
Doing more for rare diseases with less: the Congolese model of implementation of genomic medicine in Limited-Income countries
Authors: LUMAKA Aimé
Published: January 2025

Genomic medicine involves genomic information of an individual at all stage of medical care. Although the concept of genomic medicine may sound complex and difficult to implement in the Limited-Income countries, the Centre for Human genetics and the Reference Center for Rare and Undiagnosed Diseases of the University of Kinshasa have succeeded in implementing genomic medicine for rare diseases in the DR Congo. This was achieved thanks to research projects and philanthropy, and despite multiple challenges. Along the process, the challenges have led to challenge-driven innovations. The model developed here may be replicated in countries with similar limitations. Most importantly, the involvement of local government is needed to sustain and expand the progresses achieved thus far.
Lipschutz's acute vulvar ulcer : a case report from Groupe Hospitalier du Sud de l’Oise
Authors: Mumaka Floreen , Kowal Philippe , Turc Yves , Osman Zafer
Published: January 2025

Lipschutz's acute vulvar ulcer (Ulcus vulvae acutum) is a rare cause of acute genital ulceration of non-venereal origin. Even if its pathogenesis remains unknown, several studies described an association with primary Epstein-Barr virus (EBV) infection. In this article, we report the case of a 13-year-old girl, who developed a sudden and extremely painful papulonecrotic vulvar lesions, in whom biological and serological tests suggested a previous EBV infection. The management was essentially based on the prescription of analgesics. The evolution was self-resolution without relapse or scarring in average of 10 days. This entity, often mistaken for other infectious causes of genital ulcers, deserves special attention from pediatricians and gynecologists.
Received: October 25th, 2023
Accepted: October 13th, 2024
https://dx.doi.org/10.4314/aamed.v18i1.12
Association between cerebral venous thrombosis and hyperthyroidism: a case report
Authors: Ernestho-ghoud Indretsy Mahavivola , Rasolonjatovo Emilson Charles , Randriamampianina Tahianasoa , Lova Hasina Rajaonarison Ny Ony Narindra , Ahmad Ahmad , Danielle Vololontiana Hanta Marie
Published: January 2025

Cerebral venous thrombosis (CVT) associated with hyperthyroidism is rarely reported. We aimed to report a case that illustrates interactions between CVT and hyperthyroidism. The case consisted of 46 years- old woman from Madagascar who presented CVT and pulmonary embolism. The only highlighted biological abnormality was hyperthyroidism. CVT and hyperthyroidism were considered unrelated and their coexistence was fortuitous without any causality link.
Received: September 2nd, 2024
Accepted: October 29th, 2024
https://dx.doi.org/10.4314/aamed.v18i1.13
Stevens-Johnson syndrome due to Methotrexate: a case report
Authors: Osman Adli Liban , Aatif Taoufiq , Fane Modibo , El Kabbaj Driss , Achbouk Abdelhafid
Published: January 2025

Stevens-Johnson syndrome is a rare mucocutaneous disorder. It constitutes, together with toxic epidermal necrolysis (Lyell), opposite forms of a spectrum of diseases usually resulting from an adverse reaction to drugs. We report the case of a 67-year-old woman from Morocco who developed Stevens-Johnson syndrome after receiving methotrexate. The evolution was marked by death due to hemodynamic complications. Stevens-Johnson syndrome is a serious condition, with mortality in 10-34% of cases. Management consists in identifying and stopping the responsible drug, and maintaining hemodynamic and respiratory stability, care of skin lesions and pain relief. The use of prognostic scores can assist in management of some complicated cases. Methotrexate is a commonly prescribed drug because of its efficacy and cost-effectiveness/ease of administration. Therefore, physicians should be aware of the consequences of its use, with particular attention to patients with chronic renal failure in whom dosages should be adapted to renal function. This drug should not be used in end-stage patients because of its poor tolerance
Received: June 18th, 2023
Accepted: November 13th, 2024
https://dx.doi.org/10.4314/aamed.v18i1.14
Pulmonary embolism revealing coarctation of the aorta complicated by aneurysm in a 58-year-old patient: a case report
Authors: Martin Nacanabo Wendlassida , André Taryètba , Wendlassida Segda , Sawadogo Léa Françoise , Koudnoaga Samadoulougou André
Published: January 2025

Coarctation of the aorta (CAo) is defined as a narrowing of the thoracic aorta, usually located at the aortic arch and generally discovered in childhood. We report a case of incidental finding of coarctation of the aorta in a patient presenting with pulmonary embolism. The Burkinabe patient was 58 years old and had been suffering from irregular hypertension for 10 years. She was admitted with right basithoracic pain of abrupt onset, moderate intensity and no radiation. Clinical examination on admission revealed grade III arterial hypertension and an athletic thorax. Paraclinical examinations led to the diagnosis of a relative hypertensive emergency associated with pulmonary embolism on a coarctation site. The patient was treated with calcium channel blockers (Nicardipine) and alpha blockers (Eupressyl) by electric syringe pump, and curative low-molecular-weight heparin (Enoxaparin). After one week, the patient's blood pressure returned to normal, and her chest pain and dyspnea disappeared. She was discharged without curing her coarctation, due to insufficient technical resources. Coarctation of the aorta is an uncommon pathology in children. This case study shows that coarctation of the aorta can progress insidiously into adulthood. 
Received: April 3rd, 2024
Accepted: October 13th, 2024
https://dx.doi.org/10.4314/aamed.v18i1.15
Effect of an adapted physical activity program on the cardiorespiratory performance of soldiers of the Kinshasa Garrison: a randomized controlled study
Authors: Kurhenga Kabanda Gilbert , Natuhoyila Nkodila Aliocha , Ngasa Kiana Nicaise , Masudi Mundu Gustave , Batena Beya Felix Espoir , Masey Mety Rawell , Bimbi Buila Nathan , Longo- Mbenza Benjamin , Ntumba Kayembe Jean-Marie , M’Buyamba-Kabangu Jean-René
Published: January 2025

Context and objectives. The health services of the army are essential in promoting the physical condition for operational troops. The present study aimed to evaluate the impact of adapted physical activity (APA) on VO2max level and cardiorespiratory performance of soldiers. Methods. An Open, parallel, randomized controlled trial, was carried out at CECVK (Camp Lt-Colonel Kokolo, Kinshasa) from June 2016 to October 2017 in 226 sedentary soldiers assigned for 8 weeks to APA (n=119) or control (n=107). Randomization used permuted blocks of four consecutive participants. Primary endpoint: Baseline-adjusted between group difference in VO2max and cardio-respiratory performance. Results. In 122 participants (Control 42; active 80) who fully adhered to the protocol, VO2max at the end of follow-up increased from 31.4 (95% CI: 27.7-37.5) to 34.7 (30.3-37.5) ml/min/kg (control group) and from 25.8 (23.1-30.9) to 47.5 (42.4-51.1) ml/min/kg (active group); between group difference: 18.4 (15.9-18.9) ml/min/kg. Compared to the control group, VO2max in the active group was significantly improved in all categories of participants at the end of follow-up.  The rate of good performance increased from 14.3 to 23.8% (p=0.069) in the control group, from 25.3 to 71.0% (p<0.001) in the active group; between group difference: 36.1(24.8 -39.6) %. The probability of achieving good performance was greater for subjects <50 years (RRa: 2.04 [95% CI]; p=0.046), non-diabetics (1.94 [1.49-2.79]; p=0.031), without subclinical atherosclerosis (1.67[1.27-2.68]; p=0.039) and those allocated to APA (3.43[1.96-4.98]; p<0.001). VO2max and BP changes were negatively correlated. Conclusion. By improving the cardio-respiratory performance of sedentary soldiers, the APA strengthened their physical condition.
Received: June 19th, 2024
Accepted: September 30th, 2024
https://dx.doi.org/10.4314/aamed.v18i1.2
Produtividade de minicepas e enraizamento de miniestacas de sapucaia (Lecythis lanceolata)
Authors: Sant'Ana Bruna Tomaz , Berude Marciana Christo , Feletti Thaís Arão , Caldeira Marcos Vinicius Winckler , Gonçalves Elzimar de Oliveira
Published: January 2025

O objetivo deste trabalho foi avaliar a miniestaquia como técnica de propagação vegetativa e o efeito da aplicação de diferentes doses de ácido indolbutírico (AIB) no enraizamento de miniestacas de Lecythis lanceolata. Os tratamentos constituíram-se em duas coletas de brotações, nas doses de 0, 2.000, 4.000 e 8.000 mg L-1 de AIB, (fatorial 2 x 4), com quatro repetições, em delineamento inteiramente casualizado. O minijardim seminal de Lecythis lanceolata apresenta potencial para fornecimento de miniestacas. Não houve influência da aplicação de auxina no enraizamento das miniestacas, sugerindo que a espécie apresenta baixa capacidade de emitir raízes.
Roh Kudus dan Transformasi: Sebuah Kajian Biblis tentang Pembaharuan Karakter Paulus
Authors: Tafonao Diana , Waruwu Anwar Three Millenium , Tan Timotius , Sitorus Johnson
Published: January 2025

Character plays a central role in shaping individual behavior, with the presence of both good and bad character traits reflected in daily actions. This article investigates the role of the Holy Spirit in shaping character, particularly through the transformation of Paul's character. Through qualitative methods and literary analysis, this research highlights the crisis of character in society and aims to elucidate the impact of the Holy Spirit in addressing it. The findings demonstrate the Holy Spirit's role in transforming Paul's character from a persecutor into a loving and forgiving follower of Christ. The Holy Spirit serves as a comforter and helper, guiding Paul from darkness to light, and transforming his harsh character into one of gentleness and love. Paul's life testimony confirms the power of the Holy Spirit in changing hearts and human character, making them more like Christ. AbstrakKarakter memainkan peran sentral dalam membentuk perilaku individu, dengan terdapatnya karakter baik dan buruk yang tercermin dalam tindakan sehari-hari. Artikel ini menginvestigasi peran Roh Kudus dalam membentuk karakter, terutama melalui transformasi karakter Paulus. Melalui metode kualitatif dengan analisis literatur, penelitian ini menyoroti krisis karakter dalam masyarakat dan bertujuan menjelaskan dampak Roh Kudus dalam mengatasinya. Hasil penelitian menunjukkan peran Roh Kudus dalam transformasi karakter Paulus dari seorang penganiaya menjadi seorang pengikut Kristus yang penuh kasih dan pengampunan. Roh Kudus berperan sebagai penghibur dan penolong yang membawa Paulus keluar dari kegelapan menuju terang, mengubah karakter keras menjadi lembut dan penuh kasih. Kesaksian hidup Paulus menegaskan kekuatan Roh Kudus dalam mengubah hati dan karakter manusia, menjadikan mereka lebih mirip dengan Kristus.
Kurikulum Merdeka Belajar dan Implementasinya dalam Pendidikan Kristen pada Tingkat Sekolah Dasar di Pelosok Kepulauan Nias
Authors: Duha Asni Darmayanti
Published: January 2025

The independent learning curriculum is one of the programs for developing and improving the quality of education in Indonesia. However, the problems that occur with the implementation of the free learning curriculum in remote areas of the Nias Islands, especially in elementary schools, are the lack of preparedness of human resources, both educators who are not well equipped and students who are not ready to accept the free learning curriculum system and inadequate infrastructure. adequate to support the successful implementation of the independent learning curriculum in Christian education. The aims of this research consist of first, revealing the problems that occur so that they become evaluation material for both the central, provincial, and regional governments as well as for private educational institutions. Second, to offer a simple solution as an effort to implement the independent learning curriculum in remote areas of the Nias Islands, namely providing extra (gradual and continuous) teacher training and completing infrastructure. The research method used is a literature study. Based on the results of data analysis, it can be concluded that efforts to implement the independent learning curriculum in Christian education at the elementary school level in remote areas of the Nias Islands have not gone well and maximally, thereby affecting the quality of human resources produced. AbstrakKurikulum merdeka belajar merupakan salah satu program pengembangan dan peningkatkan mutu pendidikan di Indonesia. Namun, persoalan yang terjadi pada penerapan kurikulum merdeka belajar tersebut pada pelosok Kepulauan Nias, khususnya pada satu pendidikan Sekolah Dasar, yakni kurangnya kesiapan sumber daya manusia baik pendidik yang tidak dibekali dengan baik maupun siswa yang tidak siap menerima sistem kurikulum merdeka belajar dan sarana prasarana yang kurang memadai sebagai penunjang keberhasilan penerapan kurikulum merdeka belajar dalam pendidikan Kristen. Tujuan penelitian ini terdiri atas: pertama, untuk mengungkapkan masalah yang terjadi sehingga menjadi bahan evaluasi baik bagi pemerintah pusat, provinsi dan daerah serta bagi lembaga pendidikan swasta. Kedua, untuk menawarkan solusi yang sederhana sebagai upaya dalam menerapkan kurikulum merdeka belajar di pelosok Kepulauan Nias, yakni melakukan pembekalan para guru secara ekstra (bertahap dan berkesinambungan) dan melengkapi sarana prasana. Metode penelitian yang digunakan adalah studi pustaka. Berdasarkan hasil analisis data, maka dapat disimpulkan bahwa upaya penerapan kurikulum merdeka belajar dalam pendidikan Kristen pada tingkat sekolah dasar di pelosok Kepulauan Nias belum berjalan dengan baik dan maksimal sehingga memengaruhi kualitas sumber daya manusia yang dihasilkan.
Educación Física de calidad en la República Dominicana: Retos, desafíos y perspectivas
Authors: Ramírez Rodríguez Yusefy Jesús , Capellán Caraballo Rosanna Licelot , Jiménez Ramos Félix Yamil , Taveras Espinal José Ramón , Ortiz Zorrilla Freddy Ernesto , Vicente Soto Pedro Manuel , Bennasar-García Miguel Israel
Published: January 2025

La Educación Física de Calidad (EFC) representa una herramienta poderosa para el desarrollo integral de los estudiantes, un espacio pedagógico y didáctico para fomentar habilidades físicas, emocionales, cognitivas y sociales que perdurarán a lo largo de sus vidas, convirtiéndose en una piedra angular para la formación de sujetos saludables, resilientes, colaborativos y con un fuerte sentido de autoestima.

Esta obra busca analizar los retos, desafíos y perspectivas de la EFC en la República Dominicana, reflexionando sobre la importancia de transformar el modelo educativo hacia uno más integral y sustentable. A través de la investigación, se pretende generar un espacio para el debate y la acción, que impulse tanto a los responsables de la política educativa como a los docentes y estudiantes a mejorar las condiciones para el desarrollo físico y emocional de las nuevas generaciones.
Sistematización de la experiencia sobre las Guías de Trabajo Autónomo para el aprendizaje de la filosofía a partir de la educación por habilidades
Authors: CORDERO REDONDO JOAN JAVIER
Published: January 2025

Las investigaciones contemporáneas sobre la enseñanza de la filosofía son escasas, sin embargo, en la mayoría de los casos esas investigaciones no aportan al acervo de la metodología de la enseñanza y los diseños didácticos comprobados. Entre los resultados más oportunos de esta investigación está la creación y validación positiva, mediante un cuestionario a 51 personas estudiantes, de 14 diseños didácticos para enseñar y aprender filosofía en la secundaria. El paradigma en el cual se basa estos diseños didácticos filosóficos procura alentar la autonomía del pensamiento de la persona estudiante, la construcción de aprendizaje y el desarrollo de habilidades. El contexto en el que se da la esta investigación es la estrategia “Aprendo en casa” (MEP, 2020a) y el uso de Guía de Trabajo Autónomo (GTA), curso lectivo 2020 (MEP, 2020b), en un centro educativo público de secundaria.
Tertulias Pedagógicas Dialógicas, nivel de autoestima y comprensión lectora en estudiantes universitarios de nuevo ingreso.
Authors: Laorden Gutiérrez Cristina , Foncillas Beamonte Mercedes , González Araujo Elena
Published: January 2025

La investigación que se presenta pretende poner en relación los beneficios de las Tertulias Pedagógicas Dialógicas y el nivel de comprensión lectora y de autoestima del alumnado. La formación inicial en la etapa universitaria es muy importante para que los y las estudiantes adquieran una preparación de calidad que les permita implementar lo aprendido en su vida profesional y las Tertulias Pedagógicas Dialógicas han demostrado ser una práctica educativa muy eficaz. En este estudio, la muestra la forman 127 estudiantes, 47 de primer curso del grado magisterio de Educación Primaria y 80 del grado magisterio de Educación Infantil. En cuanto al género, hay una mayoría de mujeres, 105 frente a 22 varones, algo común en este grado. Para la recogida de datos se utilizan tres instrumentos: prueba de comprensión lectora (Deep Cloze), la escala de autoestima de Rosenberg y un cuestionario de percepción para conocer cómo valora el alumnado el desarrollo de las Tertulias Pedagógicas Dialógicas en su proceso formativo. Los resultados indican que el género no condiciona significativamente ni la comprensión lectora ni la autoestima entre el alumnado de nuevo ingreso en el grado de magisterio, pero hay diferencias significativas en cuanto al nivel de autoestima entre primaria e infantil. Por otra parte, la percepción del alumnado de las TPD es positiva como práctica que les ayuda a mejorar su comprensión lectora, a tener mayor confianza en sí mismos y a perder el miedo a hablar en público entre otras variables.
The role of the POCUS protocol in the diagnosis of urosepsis-caused Тakotsubo syndrome in a patient with cervical cancer. Clinical case report
Authors: Yevsieieva V.V. , Kharchenko K.V.
Published: January 2025

Background. Left ventricular dysfunction often occurs in patients with sepsis. Takotsubo syndrome is an acute and usually reversible myocardial injury without the presence of an infarct-related coronary artery. However, little is known about this syndrome in patients with septic shock. Takotsubo cardiomyopathy has a similar clinical symptoms to septic myocardial dysfunction, but the two conditions have significant differences in pathogenesis, diagnosis, and treatment.
Purpose – to draw the attention of intensivists to the fact that Takotsubo syndrome is often found in patients with septic shock and may be the true cause of myocardial dysfunction.
Materials and Methods. This report presents a clinical case of the diagnosis and management of Takotsubo syndrome due to urosepsis in a 54-year-old woman who underwent surgery for cervical cancer.
Results. As a result of the timely application of the POCUS protocol directly at the patient’s bedside, it was possible to detect the described transient dysfunction of the left ventricle in time, which radically changed the treatment tactics and saved the patient’s life.
Conclusions. The first onset of hemodynamic and respiratory deterioration should raise the suspicion of Takotsubo syndrome and prompt screening for this syndrome by echocardiography in this clinical context. Therefore, mastering and applying the POCUS protocol directly at the patient’s bedside can help in solving a complex clinical situation.
Methodology of prenatal ultrasound examinations in gastroschisis
Authors: Grebinichenko G.O. , Gordienko I.Yu. , Tarapurova O.M. , Sliepov O.K. , Ponomarenko O.P. , Soroka V.P. , Velychko A.V.
Published: January 2025

Background. Gastroschisis is a complex malformation with significant anatomic and clinical variability. At present, it is not enough just to make a prenatal diagnosis – it is necessary to perform detailed repeated evaluation of the pathological process in order to assess its severity and prognosis, and to adjust accordingly management of pregnancy, labor and neonatal period.
Purpose – to propose a methodology/algorithm of prenatal ultrasound examinations in gastroschisis, taking into account the most common associated anomalies, anatomical variants and characteristic changes during pregnancy.
Materials and methods. Data on prenatal ultrasound examinations of 175 pregnant women with fetal gastroschisis conducted during the period 2007–2020 were systematized, and also compared with clinical/surgical postnatal data in 74 cases. Ultrasound examinations were performed on the HDI 4000, ACCUVIX V20EX-EXP, ACCUVIX V10LV-EX systems, following extended protocol.
Results. Prenatal ultrasound semiotics of gastroschisis changes significantly during the pregnancy, that requires repeated exams and evaluation. Typical and rare variants of abdominal organs eventration are characterized, the main structures for detailed assessment are outlined considering clinical significance of the most common findings. Methodology of prenatal ultrasound examination of fetuses with gastroschisis is proposed that takes into account its pathological anatomy and ultrasound semiotics. It also includes correct measurement of abdominal cavity and eventrated organs, calculation of index for evaluation of the degree of viscero-abdominal disproportion, which help to determine the severity of the pathology.
Conclusions. Proposed methodology of prenatal ultrasound examination in gastroschisis allows to perform systematic assessment, to establish a complete correct prenatal diagnosis, to determine severity of the pathology and its prognosis, which are necessary for adequate choice of patientsʼ management strategy.
Resilience of Civiliarchic Democracy in the Face of Challenges and Gaps in European Integration: The Political Dimension of the Index of Civiliarchy
Authors: Aleksanyan Ashot , Aleksanyan Arusyak
Published: January 2025

The Eastern Partnership (EaP) countries face significant challenges in achieving democratic consolidation amid geopolitical tensions, authoritarian tendencies and regional conflicts. This paper examines the resilience of civiliarchic democracy as a framework to understand and address these challenges. The study employs a mixed methods approach including comparative analysis and the Civiliarchy Index to explore the interplay between European integration, democratic resilience and anti-civiliarchic forces.  To identify the main principles of EU foreign policy in the EaP countries and its normative component, a qualitative targeted content analysis of official EU documentation was used. Additionally, the method of discourse analysis was used to consider the narrative regarding the participation and lobbying from the EU and European institutions and values within the EaP countries, as well as prepare for the negotiations with EU and EU member states for the interests of EaP countries. Europeanization and democratization determine both the political and social prospects for sustainable development of the EaP countries, as well as the hybrid challenges of strategic security and the dichotomy of inter-integration conflicts.  The paper analyzes the gaps in European political integration in the EaP countries for the period from 2013 to 2023. The authors rely on studies on Europeanization and European political integration in the tradition of neo-institutionalism, as well as on the resilience of the EaP countries. The findings of the paper imply that the civiliarchic democracy the EaP countries face is thwarted by internal instability, external pressures and shortcomings in EU policies. But EU’s strategic and engagement can in some extent tackle authoritarian trends and improve democratic institutions. Theoretical and practical insight into the concept of civiliarchic democracy and its resiliency in light of the democratization literature is the main contribution of the study. Policy and scholarly implications of the findings in support of improving democratic institutions and further inclusive European integration in the EaP region are suggested.
GLOBAL SCIENTIFIC COLLABORATION IN ELAEAGNUS ANGUSTIFOLIA L. RESEARCH: AN ANALYSIS OF PUBLICATION PATTERNS AND KEY THEMES
Authors: Tanase Horia Ionut , Dobrescu Codruta Mihaela , Turtureanu Anca Gabriela , Soare Liliana Cristina , Dorobat Magdalin Leonard , Hangan Laurentiu Tony , Bucur Laura Adriana
Published: January 2025

In the context of increasing the global interest in Elaeagnus angustifolia L., this study represents the first in-depth scientometric and bibliometric analysis covering the period 2013-2023. The article discusses the evolution of research on this species, using data extracted from the Web of Science and Scopus databases, where we have analyzed 203 and respectively 188 articles. The applied methodology involves quantitative and qualitative analyzes of publications, citations, and international collaborations, highlighting the main areas of interest and the dynamics of collaboration. The results show a significant focus of research in the fields of ecology, pharmacology, and agriculture, while highlighting the growing interest in the plant's bioactive properties. The findings point out promising future research directions, such as the potential of phytoremediation and its use in alternative medicine, although the study acknowledges its limitations, including incomplete coverage of non-English literature. The analysis revealed a clear need to explore the complex interactions between Elaeagnus angustifolia L. and other species in its native and introduced ecosystems. Understanding these interactions can contribute to the development of strategies for conservation and sustainable use, emphasizing the importance of interdisciplinary studies to promote effective ecological management and maximizing the species' ecological and pharmacological benefits.
Efektivitas Sistem Informasi Manajemen Kepegawaian (SIMPEG) pada Badan Kepegawaian Daerah (BKD) Kabupaten Sidoarjo
Authors: Salsabillah Ni’matus Hilda , Mursyidah Lailul
Published: January 2025

Untuk mewujudkan informasi kepegawaian yang menyeluruh, akurat dan cepat serta melakukan peningkatan efektivitas dan efisiensi khususnya pada bidang pengelolaan informasi dan pengolahan data, dimanfaatkan sistem informasi bernama SIMPEG. Tujuan dari penelitian ini ialah menganalisis dan mendeskripsikan efektivitas SIMPEG pada BKD Kabupaten Sidoarjo dengan menggunakan metode kualitatif deskriptif dengan pendekatan melalui observasi dan wawancara serta menggunakan jenis data primer dan sekunder. Pada penelitian ini, penulis menggunakan teknik purposive sampling. Adapun teori yang digunakan dalam penelitian ini ialah teori efektivitas menurut Richard M. Steers (1980:1). Terdapat tiga indikator dalam teori ini yakni pencapaian tujuan, integrasi dan adaptasi. Pada indikator pencapaian tujuan peneliti menemukan bahwa pencapaian tujuan dilakukan secara bertahap. Kemudian pada indikator integrasi, BKD Kabupaten Sidoarjo telah melakukan sosialisasi kepada seluruh ASN yang terlibat meskipun hanya di awal kemunculan SIMPEG. Sedangkan pada indikator adaptasi, baik sumber daya sarana dan prasarana sudah sesuai dengan kebutuhan yang diperlukan meskipun terus terjadi pengembangan SIMPEG.
Efektivitas Program Bantuan Sembako Terdampak Covid-19 di Desa Wunut Kecamatan Porong Kabupaten Sidoarjo
Authors: Sekarini Putri Normalita Dwi , Choiriyah Ilmi Usrotin
Published: January 2025

Pandemi covid-19 tidak hanya memberikan masalah bagi keseatan masyarakat, namun juga bagi perekonomian. Sehingga pemerintah memberikan program bantuan sembako terdampak covid-19 untuk meringankan beban masyarakat yang terdampak covid-19. Tujuan dari penelitian ini ialah untuk mendeskripsikan efektifitas program bantuan sembako terdampak covid-19 pada Desa Wunut Kecamatan Porong, Kabupaten Sidoarjo dengan menggunakan metode kualitatif deskriptif melalui pendekatan pbservasi dan wawancara serta jenis data primer dan sekunder. Pada penelitian ini, penulis menggunakan teknik purposive sampling dengan fokus penelitian teori efektivitas menurut Campbell. Terdapat empat indikator dalam teori ini yakni keberhasilan program, ketepatan sasaran, pencapaian tujun dan pemantauan program. Pada indikator keberhasilan program, Pemdes Wunut telah melakukan sosialisasi terkait program tersebut. Dan pada indikator ketepatan sasaran, Pemdes Wunut telah membagikan sembako kepada yang memang membutuhkan. Kemudian pada indikator pencapaian tujuan, program ini telah memberikan dampak yang baik bagi masyarakat Desa Wunut. Serta pada indikator pemantauan program Pemdes Waun melakukannya melalui via WA.
Village Fund Direct Cash Assistance and Its Role in Poverty Reduction: An Empirical Analysis from Indonesia
Authors:   Student of Master of Public Administration Program, Gorontalo State University, Gorontalo, Indonesia, Ismail Muhammad Ronal Istanto , Igirisa Irawati ,   Lecturer of Master of Public Administration Program, Gorontalo State University, Gorontalo, Indonesia, Mozin Sri Yulianty ,   Lecturer of Master of Public Administration Program, Gorontalo State University, Gorontalo, Indonesia
Published: January 2025

The study aims to find out and describe the effectiveness of the Village Fund Direct Cash Assistance program for the poor in Dungaliyo District. The research approach used is a qualitative method with a descriptive research method and a research procedure carried out by observation and interviews with informants. The data analysis technique used is an interactive analysis of the miles and huberman model. The results of the study show that the Village Fund Direct Cash Assistance Program (BLTDD) for the poor in Dungaliyo District, Gorontalo Regency has made a positive contribution in improving the welfare of people in need. The program has generally been running well although there is room for improvement, especially in target accuracy, socialization, and monitoring. A more holistic approach to implementation and evaluation can increase the effectiveness of the program, resulting in a more equitable and sustainable positive impact on the poor. The results of each sub-focus are: (1) the accuracy of the targets of the BLT Village Fund program in Dungaliyo District has been quite good with the efforts to improve recipient data carried out by the village government. While there are still challenges in reaching all poor families equally, the steps taken demonstrate a commitment to ensuring that assistance is received by those who really need it. (2) the socialization of the BLT Village Fund program in Dungaliyo District has been carried out through various information channels, including the village government and related officials. However, the implementation needs to be more intensive so that the public better understands the objectives, benefits, and mechanisms of the program. (3) the main purpose of the BLT Dana Desa program is to help poor families meet their basic needs and support the economic recovery of the village. In Dungaliyo District, this program has been quite effective in reducing the economic burden of the poor. (4) monitoring of the implementation of the Village Fund BLT program in Dungaliyo District has been carried out routinely by the village government and related parties. This effort is quite effective in ensuring that assistance is received by those who are eligible.
Allelic frequencies of genes associated with productive traits in western Mexican boars
Authors: Ayala-Valdovinos Miguel , Galindo-García Jorge , Duifhuis-Rivera Theodor , Michel-Regalado Néstor , Virgen-Méndez Abraham , García-Sánchez Luís
Published: January 2025

The ESR1, PRLR, and RYR1 genes have previously been associated with traits of productive interest. The objective of this study was to determine the allelic frequencies of genes associated with productive traits in boars from pig farms in western Mexico. A total of 140 boars of six breeds, Duroc, Hampshire, Landrace, Piétrain, and Yorkshire, and Yorkshire/Landrace crosses were sampled. The pigs were genotyped via polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques. The two alleles of the ESR1 gene were identified in the six breeds, but only BB homozygotes were recognized in Yorkshire pigs (0.2) and their crosses (0.05). The A and B alleles of the PRLR gene were distinguished in all the breeds studied, recognizing a considerable variability in the allele frequencies. Due to the allelic diversity and its effects evidenced in previous publications, it is suggested to evaluate the association of each genotype with the reproductive parameters to be improved in order to determine which genotype is more relevant in each population. In the RYR1 gene, the mutant allele causing PSS was found in all the breeds studied, which can generate pigs with PSE meat. It is recommended that the selection of boars of any breed to be used as breeders includes a genotyping test. Knowing the genotypes in boars can be used as a way to select better breeders.
Gamification in education: didactic strategies to strengthen formative assessment
Authors: Aguayo Litardo Josselyn Paola , Lozano Rivera Martin Wilson , Alejandro Franco Ana Isabel , Sierra Alvarado Rocío Elena , Villao Jácome Kira Katiuska
Published: January 2025

This research aimed to propose gamification teaching strategies to strengthen the upper basic formative evaluation in a school in the Mocache canton, Ecuador 2023. The research was applied, with a non-experimental, transversal descriptive approach. 14 upper elementary teachers were considered. Among the main findings, 57.14% of teachers determined the degree of student skill development through the gamification strategies applied in class as Good; 57.14% perceive the degree of availability of resources and their use as Regular, while 50% consider the degree of active participation of students to be Regular. In conclusion, there is no active participation on the part of the students because the implementation of teaching methods that encourage active participation does not meet expectations, preventing them from acquiring the necessary knowledge and skills during the formative evaluation.