bluuebunny/crossref_metadata_2025 huggingface dataset:
Overcoming the Inadequacy of Economic Dynamics Models
Authors: Vasylenko Yuriy
Published: May 2022

Known models of economic dynamics are too aggregate, so inadequate to the real economy. The analyst will not be able to identify the real dynamics of the economy among the big mistakes. They have no connection between investments, their efficiency, and the rate of economic growth. There is no transition from the optimal share of savings in the country to the agents’ optimal shares, managing investment sources.To link investment and the pace of economic growth, the author introduced the concept of technical productivity of investments, which measures their ability to change the rate of material or labor costs.Based on the technical productivity of investment, the author has derived the equation (not identity) of economic dynamics.Instead of the highly aggregated models, the author developed an adequate causal simulation model, reflecting the economy as a closed system with positive feedback of the investment from incomes and economic growth from investment. The author determined the dynamics of the Ukrainian economy with different technical productivity of investment on this model.
Trophoblastic Disease: Review of the Literature
Authors: Launikonytė Gabrielė , Korsakaitė Klaudija , Bužinskienė Diana
Published: May 2022

The purpose of this literature review is to discuss the most effective gestational trophoblastic disease diagnostic and treatment methods. Also, to introduce some of the novel treatment options currently being explored. A comprehensive research was carried out on scientific databases of MEDLINE and PubMed over the time period of 2014 to 2021. According to literature sources initial gestational trophoblastic disease diagnosis is multimodal: encompassing clinical features, quantitative human chorionic gonadotropin titers and pelvic ultrasonography. Pelvic magnetic resonance imaging, body computed tomography, chest radiography and angiography are the methods usually used for overall disease staging and metastases detection. The best treatment method is designated with reference to individual features of the patient and the disease. Conventional treatment consists of hysterectomy and chemotherapy; however, the use of new methods, such as directed enzyme prodrug therapy is also being attempted to cure metastasized and/or resistant gestational trophoblastic neoplasias. Most women with gestational trophoblastic disease can be successfully managed with preservation of reproductive function due to early diagnosis in the first trimester of pregnancy. It is important to identify gestational trophoblastic disease promptly and adjust specific treatment for every patient properly to minimize various complications.
Xth Triennial Meeting of the Lithuanian Society of Coloproctologists
Authors: Samalavičius Narimantas Evaldas
Published: May 2022

The Lithuanian Society of Coloproctologists X triennial meeting with International Conference Mayo Clinic days in Vilnius, Lithuanian–Turkish session and The International Society of University Colon and Rectal Surgeons Session. Vilnius, May 12 - 13, 2022.
Self-Government Bodies in Russia: Formation and Development Policies
Authors: Babaeva Yulia , Lebedeva Margarita , Mikhaylenko Natalya , Olympiev Anatoly , Soloviev Andrey , Eriashvili Nodari
Published: May 2022

The article aims at studying the legal nature and essence of local self-government bodies in the Russian Federation as exemplified by the theoretical and legal comprehension of the historical aspects of forming local self-government bodies. The article uses the methods of induction and systemic scientific analysis, as well as comparative-legal and historical methods. The authors of the article proved that the implementation of the principles of local self-government in the Russian state apparatus became effective since it is based on objective economic, political and social prerequisites and conditions. As a result, all cities and rural settlements became municipalities.Keywords: Local self-government; Constitution; Municipal authority; Municipal structure; Human rights. Badan Pemerintahan Lokal di Rusia: Kebijakan Pembentukan dan Pengembangan AbstrakArtikel ini bertujuan untuk mempelajari sifat hukum dan esensi dari badan-badan Pemerintahan Lokal di Federasi Rusia, sebagaimana yang dicontohkan oleh pemahaman teoretis dan hukum dari aspek-aspek sejarah pembentukan badan-badan pemerintahan lokal sendiri. Artikel ini menggunakan metode induksi dan analisis ilmiah sistemik, serta metode komparatif-hukum dan historis. Penulis artikel membuktikan bahwa penerapan prinsip-prinsip pemerintahan lokal sendiri di aparatur negara Rusia menjadi efektif karena didasarkan pada prasyarat dan kondisi ekonomi, politik dan sosial yang objektif. Akibatnya, semua kota dan pemukiman pedesaan menjadi kotamadya.Kata Kunci: Pemerintahan Daerah Lokal; Konstitusi; Otoritas Kota; Struktur Kota; Hak Asasi Manusia.Органы местного самоуправления в России: Политика формирования и развития АннотацияСтатья направлена на изучение правовой природы и сущности органов местного самоуправления в Российской Федерации на примере теоретико-правового осмысления исторических аспектов формирования органов местного самоуправления. В статье используются методы индукции и системного научного анализа, а также сравнительно-правовой и исторический методы. Автор статьи доказал, что реализация принципов местного самоуправления в российском государственном аппарате стала эффективной, поскольку основывается на объективных экономических, политических и социальных предпосылках и условиях. В результате все города и сельские поселения стали муниципалитетами.Ключевые слова: Местное самоуправление; Конституция; Муниципальная власть; Муниципальное устройство; Права человека.
Vegetarian Diet, Growth, and Nutrition in Early Childhood: A Longitudinal Cohort Study
Authors: Elliott Laura J. , Keown-Stoneman Charles D.G. , Birken Catherine S. , Jenkins David J.A. , Borkhoff Cornelia M. , Maguire Jonathon L. ,   on behalf of the TARGet KIDS! COLLABORATION
Published: May 2022

OBJECTIVES

The primary objective of this study was to examine the relationships between vegetarian diet and growth, micronutrient stores, and serum lipids among healthy children. Secondary objectives included exploring whether cow’s milk consumption or age modified these relationships.

METHODS

A longitudinal cohort study of children aged 6 months to 8 years who participated in the TARGet Kids! cohort study. Linear mixed-effect modeling was used to evaluate the relationships between vegetarian diet and BMI z-score (zBMI), height-for-age z-score, serum ferritin, 25-hydroxyvitamin D, and serum lipids. Generalized estimating equation modeling was used to explore weight status categories. Possible effect modification by age and cow’s milk consumption was examined.

RESULTS

A total of 8907 children, including 248 vegetarian at baseline, participated. Mean age at baseline was 2.2 years (SD 1.5). There was no evidence of an association between vegetarian diet and zBMI, height-for-age z-score, serum ferritin, 25-hydroxyvitamin D, or serum lipids. Children with vegetarian diet had higher odds of underweight (zBMI <−2) (odds ratio 1.87, 95% confidence interval 1.19 to 2.96; P = .007) but no association with overweight or obesity was found. Cow’s milk consumption was associated with higher nonhigh-density lipoprotein cholesterol (P = .03), total cholesterol (P = .04), and low-density lipoprotein cholesterol (P = .02) among children with vegetarian diet. However, children with and without vegetarian diet who consumed the recommended 2 cups of cow’s milk per day had similar serum lipids.

CONCLUSIONS

Evidence of clinically meaningful differences in growth or biochemical measures of nutrition for children with vegetarian diet was not found. However, vegetarian diet was associated with higher odds of underweight.
Scaffolding Parenting and Health Development for Preterm Flourishing Across the Life Course
Authors: McKenzie Kamryn , Lynch Emma , Msall  Michael E.
Published: May 2022

Advances in obstetrics and neonatal medicine have resulted in improved survival rates for preterm infants. Remarkably, >75% extremely (<28 weeks) preterm infants who leave the NICU do not experience major neurodevelopmental disabilities, although >50% experience more minor challenges in communication, perception, cognition, attention, regulatory, and executive function that can adversely impact educational and social function resulting in physical, behavioral, and social health issues in adulthood. Even late premature (32–36 weeks) infants have more neurodevelopmental challenges than term infants. Although early intervention and educational programs can mitigate risks of prematurity for children’s developmental trajectories, restrictive eligibility requirement and limitations on frequency and intensity mean that many premature infants must “fail first” to trigger services. Social challenges, including lack of family resources, unsafe neighborhoods, structural racism, and parental substance use, may compound biological vulnerabilities, yet existing services are ill-equipped to respond. An intervention system for premature infants designed according to Life Course Health Development principles would instead focus on health optimization from the start; support emerging developmental capabilities such as self-regulation and formation of reciprocal secure early relationships; be tailored to each child’s unique neurodevelopmental profile and social circumstances; and be vertically, horizontally, and longitudinally integrated across levels (individual, family, community), domains (health, education), and time. Recognizing the increased demands placed on parents, it would include parental mental health supports and provision of trauma-informed care. This developmental scaffolding would incorporate parenting, health, and developmental interventions, with the aim of improved health trajectories across the whole of the life course.
Prevention and Management of High-Burden Noncommunicable Diseases in School-Age Children: A Systematic Review
Authors: Jain Reena P , Als Daina , Vaivada Tyler , Bhutta Zulfiqar A
Published: May 2022

BACKGROUND AND OBJECTIVES

Noncommunicable diseases (NCDs) are chronic conditions requiring health care, education, social and community services, addressing prevention, treatment, and management. This review aimed to summarize and synthesize the available evidence on interventions from systematic reviews of high-burden NCDs and risk factors among school-aged children.

METHODS

The following databases were used for this research: Medline, Embase, The Cochrane Library, and the Campbell library. The search dates were from 2000 to 2021. We included systematic reviews that synthesized studies to evaluate intervention effectiveness in children aged 5 to 19 years globally. Two reviewers independently extracted data and assessed methodological quality of included reviews using the AMSTAR 2 tool.

RESULTS

Fifty studies were included. Asthma had the highest number of eligible reviews (n = 19). Of the reviews reporting the delivery platform, 27% (n = 16) reported outpatient settings, 13% (n = 8) home and community-based respectively, and 8% (n = 5) school-based platforms. Included reviews primarily (69%) reported high-income country data. This may limit the results’ generalizability for school-aged children and adolescents in low- and middle- income countries.

CONCLUSIONS

School-aged children and adolescents affected by NCDs require access to quality care, treatment, and support to effectively manage their diseases into adulthood. Strengthening research and the capacity of countries, especially low- and middle- income countries, for early screening, risk education and management of disease are crucial for NCD prevention and control.
Digital Interventions for Universal Health Promotion in Children and Adolescents: A Systematic Review
Authors: Oh Christina , Carducci Bianca , Vaivada Tyler , Bhutta Zulfiqar A
Published: May 2022

BACKGROUND AND OBJECTIVES

Digital media has been used mostly to deliver clinical treatments and therapies; however limited evidence evaluates digital interventions for health promotion. The objective of this review is to identify digital interventions for universal health promotion in school-aged children and adolescents globally.

METHODS

Eligible articles were searched in PubMed, Embase, Medline, Ovid SP, The Cochrane Library, Cochrane Central Register of Controlled Trials, WHO regional databases, Google Scholar, and reference lists from 2000 to March 2021. Randomized controlled trials and quasi-experimental studies evaluating interventions that promote health in school-aged children and adolescents (5–19.9 years) were included. Methods were conducted in duplicate. Where possible, data were pooled with a random-effects model.

RESULTS

Seventy-four studies were included (46 998 participants), of which 37 were meta-analyzed (19 312 participants). Interventions increased fruit and vegetable consumption (servings per day) (mean difference [MD] 0.63, 95% confidence interval [CI] 0.21 to 1.04; studies = 6; P = .003; high quality of evidence), and probably reduced sedentary behavior (MD −19.62, 95% CI −36.60 to −2.65; studies = 6; P = .02; moderate quality of evidence), and body fat percentage (MD −0.35%, 95% CI −0.63 to −0.06; studies = 5; P = .02; low quality of evidence). The majority of studies were conducted in high-income countries and significant heterogeneity in design and methodology limit generalizability of results.

CONCLUSIONS

There is great potential in digital platforms for universal health promotion; however, more robust methods and study designs are necessitated. Continued research should assess factors that limit research and program implementation in low- to middle-income countries.
Interventions Promoting Child Sexual and Reproductive Health and Rights in LMICs: A Systematic Review
Authors: Fantaye Arone Wondwossen , Buh Amos Wung , Idriss-Wheeler Dina , Fournier Karine , Yaya Sanni
Published: May 2022

OBJECTIVE

Middle childhood is a critical period for physical, social, behavioral, and cognitive changes. A positive and healthy sexual and reproductive health and rights (SRHR) foundation can minimize SRHR risks, leading to better outcomes. Our objective is to identify effective educational interventions promoting or supporting the SRHR of school-age children in low and middle-income countries.

DATA SOURCES

Medline, Embase, CINAHL, APA PsycInfo, ERIC, Cochrane Central Register of Controlled Trials, Education Source, Web of Science, SciELO Citation Index, Global Health, and Sociological Abstract were searched from 2000 to December 2020.

STUDY SELECTION

Eligible articles had a sample mean age between 5 and 10 years, quantitatively tested the effects of educational interventions against a comparison group, and measured SRHR related outcomes.

DATA EXTRACTION

Data extracted from the 11 eligible articles were study methods, participant characteristics, interventions and comparisons, outcome measures, and results.

RESULTS

The review found evidence of significant intervention effects on protective knowledge, attitudes, behaviors, and skills for preventing sexual violence and HIV infection. The strongest evidence was for significant improvements in children’s knowledge of child sexual abuse prevention concepts and strategies.

LIMITATIONS

A meta-analysis could not be performed because most studies lacked randomization, included no information on the magnitude of effects, and had inadequate follow-up evaluations to truly assess retention. Only a few studies contributed to findings on protective attitudes, behaviors, and skills against child sexual abuse, gender-based violence, and human immunodeficiency virus infection, as well as physiologic outcome.

CONCLUSIONS

The educational interventions demonstrated significant improvements in primary school children’s protective capacities, especially in their protective knowledge against sexual abuse.
LEGAL FRAMEWORK FOR CRIMINOLOGICAL MONITORING BY THE NATIONAL POLICE OF UKRAINE
Authors: Sydorenko N. S.
Published: May 2022

The relevance of the article is that at the beginning of the study of the legal framework for criminological monitoring by the National Police of Ukraine, it should be noted that no legal act regulating police activities contains a definition of criminological monitoring, although the concept of monitoring is used, in particular in monitoring operational environment. The article examines the current state of monitoring by the police. Based on the research, the range of problematic issues related to police monitoring is outlined, and ways to solve them are suggested. No legal act regulating the activities of the police contains a definition of criminological monitoring, although the concept of monitoring is used, in particular in the aspect of monitoring the operational situation. The National Police of Ukraine is the central body of executive power that serves society by ensuring the protection of human rights and freedoms, combating crime, maintaining public safety and order. The main tasks of the national police are: ensuring public safety and order; protection of human rights and freedoms, as well as the interests of society and the state; crime prevention; providing, within the limits specified by law, assistance services to persons who, for personal, economic, social reasons or as a result of emergencies, need such assistance. In the Law of Ukraine “On the National Police” “monitoring” is not used by the legislator, although in some way the monitoring powers are reflected in the content of Art. 25 “Powers of the police in the field of information and analytical support”. Thus, the police carry out information and analytical activities solely to exercise their powers under the law. The concept of “criminological monitoring” is a broader concept than “monitoring of a criminogenic situation (situation)”. These concepts are close, but not identical, they differ in terms of content (monitoring of the operational situation includes observation, measurement and evaluation not only of certain criminal phenomena, but also other emergencies and offenses) and purpose.
THE IMPORTANCE OF THE CAUSAL FOR THE SOLUTION OF PROBLEM ISSUES OF CRIMINAL LAW
Authors: Benkivskyi V. O.
Published: May 2022

The article considers causality (causal approach) and its significance for solving criminal law issues. The emphasis on the causal approach is carried out at the methodological level of research that is the basic concepts of cause and condition, system, structure, etc. are considered. The author draws attention to the fact that in addition to the cause, which has legal criminal significance, it is necessary to consider such elements of the causal complex as conditions, reasons, incentives, circumstances that are necessary to clarify the mechanism of causing legal value. The author notes that if the cause and condition based on their importance in criminal law have the characteristics of «full» factors, the reason, incentive, circumstances can be considered and evaluated as subcausal factors. These subcausal factors are taken into account in criminal law indirectly and, as the author notes, are rather criminal proceedings. The article separately considers the possibility of using among the causal (causal) factors of psychological attitude; it is noted that in accordance with the approaches of the psychological school of Professor Uznadze, the installation is considered at the subconscious level and can’t be considered in the implementation of criminal law assessments. The article mentions a number of other problems related to the causal approach in resolving issues of legal, criminal and legal nature. In particular, attention is focused on the term «causal complex», the problem of the inverse effect of the consequence on the cause, the separation of «social» causality from «natural» and others. The author considers in the article the importance of conducting a causal analysis in the study of criminal law issues. It is noted that the methodological establishment of the criterion of the cause of the phenomenon (consequence) is also necessary in the case of ambiguous (several or more causes and consequences) causal relationships or complex causality. The author notes that the «vector» of the causal relationship is complicated given the previous aspects of the study.
GENESIS OF CRIMINAL RESPONSIBILITY FOR APPROPRIATION, POSSESSION OF MILITARY PROPERTY USING OFFICIAL RANK COMMITTED BY A MILITARY OFFICER
Authors: Demianovskyi V. V.
Published: May 2022

The article provides a comprehensive study of the emergence and development of criminal liability for dishonest appropriation, military property acquiring through abuse of official rank committed by a military official. The research of normative-legal acts of different periods of origin of the Ukrainian statehood is carried out, in particular disclosing the essence of responsibility for dishonest appropriation, military property obtained through abuse, misuse of official rank performed by a military officer. Such normative legal acts are Russkaya Pravda, Sudebniki of 1468, 1550, Statutes of 1529, 1566 and 1588, Rights and Institutions of Little Russia, ‘Conciliar Code’ of 1649, Military Article of 1715, ‘The civil rights of the Little Russian people’ of 1743, ‘Field criminal law’ of 1812, Code of Laws of 1832 (Criminal Code), ‘Statute of a denomination or police officer’ of 1782, the Statute of Punishment, the Village Court Statute of 1839, Penal and Correctional Regulations of 1845, Statutes of Public Administrations ‘Code of military regulations’ of 1869 ‘Statutes of Punishment Criminal Code’ of 1903, ‘Code on weapon requisition’ of 1917, Criminal Codes of the USSR of 1922, 1927, and 1960, decrees on ‘Criminal liability for theft of state and public property’, and on ‘Strengthening the protection of personal property of citizens’ of 1947, Criminal Code of Ukraine of 2001, etc. Having conducted research on legislative acts that were relevant in today's Ukraine at different times, having reviewed scientific works of domestic and foreign scientists, the main aspects of the formation and development of criminal liability for dishonest appropriation, military property acquiring through abuse of official rank committed by a military official are proposed. It is investigated that the norms of the Military Article of Peter I, which regulated the relations in the army, significantly affected the development and approval of the current military criminal legislation of Ukraine. Much attention in the article is paid to the Criminal Codes of 1922, 1927 and 1960, because they see an experiment in the classification of criminal law, taking into account and improving the rules of past regulations, and clearly states the responsibility for the criminal offense researched by us.
O encontro com a memória e o vislumbre de identidades
Authors: Mariano Agnes Francine de Carvalho
Published: May 2022

O artigo analisa aportes teórico-disciplinares de pesquisas do campo da comunicação interessadas no tema da entrevista jornalística. Foram observados 23 artigos apresentados no Encontro Nacional de Pesquisadores em Jornalismo – SBPJor, entre 2005 e 2019, em busca dos autores e conceitos mais recorrentemente acionados nos debates sobre a entrevista. Assim como identificado em momento anterior da pesquisa, que analisou artigos da Intercom, foram localizados os seguintes eixos de abordagem: discurso, interação/tipologias, memória/identidade. Aqui, escolhemos observar mais de perto os debates e autores relacionados aos estudos da memória, com destaque para Maurice Halbwachs (1990), Paul Thompson (2002), José Carlos Sebe Bom Meihy (2002), Verena Alberti (2005) e Beatriz Sarlo (2007), todos referenciados em mais de uma pesquisa. O artigo avança na reflexão sobre as possíveis interfaces entre os estudos interessados na memória e as questões identitárias, âmbitos considerados independentes por alguns e indissociáveis, por outros. Também discute qual o lugar dos debates sobre memória e identidade no mundo contemporâneo.
Saberes docentes no ensino de crianças com deficiência dos Anos Iniciais: um estudo no município de Capão da Canoa
Authors: Dias Messerschmitt Taina Patricia , Forell Leandro
Published: May 2022

O presente artigo aborda conteúdo sobre os saberes docentes no ensino de crianças com deficiência e tem o objetivo de compreender quais são as fontes de conhecimentos que orientam a prática pedagógica de docentes de uma escola pública do município de Capão da Canoa com alunos com deficiência. Ainda, é utilizado concepções de Maurice Tardif (2010) sobre saberes docentes para analisar e refletir acerca desse universo que compõe a prática pedagógica. A metodologia escolhida foi a qualitativa com abordagem descritiva que assume a forma de estudos causais comparativos/estudos post facto. O instrumento de coleta dos materiais foi uma entrevista semiestruturada elaborada para três docentes dos anos iniciais de uma escola regular que possuem estudantes com deficiência em suas turmas. A pesquisa revelou que uma forma das professoras buscarem por novos saberes para integrar à prática pedagógica com alunos com deficiência, está ancorada, principalmente, na experiência profissional de outros docentes, assim, o diálogo com professores que estudam sobre educação inclusiva e que trabalham na mesma escola, são uma forma de orientar a prática e originar novos saberes.

Palavras-chave:Saberes docentes; Educação inclusiva; Experiência profissional.
Severity of disease and the quality of life indexes in infants with atopic dermatitis
Authors: Köse Seda Şirin , Akelma Zülfikar , Özmen Serap
Published: May 2022

Background: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease. In this study, the relationship between the severity of AD and the quality of life (QoL) of patients and their families were evaluated; also, the factors that predict the severity of AD and the QoL index were determined.
Methods: Infants with AD were enrolled in the study. Pruritus, sleep disturbance, and dermatitis severity scores were obtained. The QoL of infants was assessed using the Infants’ Dermatitis Quality of Life Index (IDQOL), while the Family Dermatology Life Quality Index (FDLQI) was used to assess the impact of disease on the QoL of parents.
Results: 122 patients diagnosed with AD were enrolled in the study. The correlation analysis of score showed a positive correlation between IDQOL and FDLQI (r = 0.444, p < 0.0001). Positive correlations between the pruritus, sleep disturbance, Severity Scoring of Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and dermatitis severity scores and the QoL indexes were found. While pruritus, sleep disturbance scores, and EASI were the most significant parameters for predicting a severe SCORAD score, IDOQL, FDLQI, and SCORAD were the most significant parameters for predicting severe EASI. In the analysis of QoL indexes, sleep disturbance and FDLQI were the most significant parameters for predicting severe IDQOL index, while IDQOL was the most significant parameter for predicting severe FDLQI scores.
Conclusions: AD has a negative effect on the QoL of infants and their parents. Pruritus and sleep disturbance should be evaluated during clinical practice due to their strong relationship with disease severity and QoL index.
Safety of an inactivated COVID-19 vaccine in patients with - wheat-dependent exercise-induced anaphylaxis
Authors: Du Zhirong , Yin Jia
Published: May 2022

Background: Inactivated vaccines against coronavirus disease-2019 (COVID-19) offer an effective public health intervention to mitigate this devastating pandemic. However, little is known about their safety in patients with wheat-dependent exercise-induced anaphylaxis (WDEIA).
Methods: We recruited 72 WDEIA patients and 730 healthy matched controls who received an inactivated COVID-19 vaccine. Participants were monitored for 4 weeks after each immunization for adverse reactions and completed questionnaires regarding local and systemic reactions at 7 and 28 days after each vaccination. For those who had received the COVID-19 vaccine prior to enrollment, adverse event data were obtained retrospectively.
Results: Local and systemic adverse events occurred at similar rates in the WDEIA group and the control group. In both groups, injection-site pain and fatigue were the most common local and systemic reactions, respectively. Compared with healthy controls, more allergic events were reported in the WDEIA group (after dose 1, 0.5% vs. 4.2%, p=0.019; after dose 2, 0% vs. 1.4%, p=0.089). Allergic reactions mainly manifested as rash, urticaria, and edema, which were mild and controllable. No serious allergic events were reported.
Conclusions: The adverse event profile of inactivated COVID-19 vaccine did not differ between WDEIA patients and healthy controls. The risk of allergic reactions in patients with WDEIA seems higher, but no anaphylaxis was reported, and the allergic reactions were controllable. Inactivated COVID-19 vaccines appear to be well-tolerated in WDEIA patients, but patients with potential allergy risks should be cautious.
Knockdown of EPSTI1 alleviates lipopolysaccharide-induced inflammatory injury through regulation of NF-κB signaling in a cellular pneumonia model
Authors: Kari Adilijiang , M Zhihua , Aili Zhayidan , Adili Ayinuerguli , Hairula Nadire , Abuduhaer Abulaiti
Published: May 2022

Background: Although early diagnosis, antibiotic therapies, corticosteroid application, and health care services are conventional managements for pneumonia, antibiotic resistance and adverse reactions remain as limitations for pneumonia treatment.
Objectives: The study attempted to evaluate the potential role of EPSTI1 against pneumonia and reveal its underlying mechanism.
Methods: Lipopolysaccharide (LPS) (5, 10, and 20 μg/mL) was applied in WI-38 cells to establish the in vitro pneumonia model. Knockdown of epithelial-stromal interaction 1 (EPSTI1) was performed by transfection with EPSTI1 siRNA (siEPSTI1) into LPS-treated cells. Cell Counting Kit-8 assays were implemented to measure cell viability, and apoptotic cells were detected using flow cytometry. Interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) were quantified using enzyme-linked immunosorbent assay (ELISA). Immunoblotting and quantitative real-time polymerase chain reaction (qRT-PCR) were conducted to quantify EPSTI1 expression, and proteins related to nuclear factor κ-light-chain-enhancer of activated B cell (NF-κB) signaling, including p-p65, p65, p-IκBα, and IκBα.
Results: EPSTI1 was highly expressed in LPS-treated WI-38 cells. Cell apoptosis was promoted, and cell viability was inhibited after being exposed to LPS. Besides, IL-1β, IL-6, and TNF-α were dramatically upregulated. Knockdown of EPSTI1 restored cell viability, inhibited cell apoptosis, and attenuated expressions of proinflammatory factors. Additionally, knockdown of EPSTI1 visibly decreased the increased ratios of p-p65/p65 and p-IκBα/IκBα induced by LPS. Knockdown of EPSTI1 alleviated inflammatory injury through the inactivation of the NF-κB pathway.
Conclusions: These results provided promising management in preventing pneumonia in patients.
PLCE1 alleviates lipopolysaccharide-induced acute lung injury by inhibiting PKC and NF-κB signaling pathways
Authors: Qiu Xianpeng , Chen Jijun , Li Jinsong , Pan Linyan
Published: May 2022

Background: Acute lung injury (ALI) is a clinical syndrome characterized by hyperosmotic pulmonary edema and increased alveolar fluid. Phospholipase C epsilon-1 (PLCE1), identified as a member of phospholipase family, and the relationship between PLCE1 and lung injury is not clear.
Objective: To assess the possible role of Phospholipase C Epsilon 1 (PLCE1) in Acute lung injury (ALI) progression and related mechanisms.
Materials and methods: The effects of LPS and PLCE1 on cell viability and apoptosis were examined by MTT and flow cytometry. Also, the level of PLCE1 was controlled by transfection of its plasmid and shRNA. The inflammatory response in response to PLCE1 overexpression or ablation was analyzed by quantitative PCR and ELISA assay. And the involvement of PKC and NF-κB signal pathway were detected by Immunoblot.
Results: In this study, we developed a LPS-induced ALI cell model. We found PLCE1 was upregulated in LPS-induced pneumonia cells and affected cell viability. Also, knockdown of PLCE1 reduced LPS-induced apoptosis of pneumonia cells. In addition, depletion of PLCE1 suppressed LPS-induced secretion of proinflammatory cytokines in pneumonia cells. Mechanically, we found depletion of PLCE1 inhibited PKC and NF-κB signal pathway, and therefore alleviated LPS-induced ALI.
Conclusion: We therefore thought PLCE1 could serve as a promising drug for ALI.
Molecular characterization of organically bound copper in the marine environment
Authors:   , Babcock-Adams Lydia
Published: May 2022

Marine microbes require copper (Cu) for a variety of key enzymes and can therefore experience limitation when concentrations are low. However, when Cu concentrations are too high, it becomes toxic causing decreased cell growth and even cell death. Laboratory culture experiments have shown that a diverse array of microbes produce organic ligands that complex Cu (CuL) and buffer the free ion concentration, which is the most bioavailable fraction. In this way, the microbes impose a control on the speciation of Cu, decreasing the toxic effects of Cu and making seawater conditions favorable for growth. Studies have shown that CuL complexes produced in laboratory cultures have similar complexation strengths to those found in seawater samples, which suggests a biological source of CuLs in seawater where dissolved Cu is almost entirely bound by organic ligands. However, information about individual CuL complexes is lacking which limits our understanding of the sources, sinks, and cycling of dissolved Cu. In order to fill this gap in knowledge, molecular level information about CuL complexes produced in culture and found in seawater must be obtained. To investigate this, liquid chromatography (LC) was coupled to two mass spectrometers (MS), an inductively coupled plasma (ICP) MS and an electrospray ionization (ESI) MS. By using data supplied by both techniques, the molecular charateristics of CuLs were determined laboratory cultures of the marine diatom Phaeodactylum tricornutum and the cyanobacterium Synechococcus, as well as investigating the distribution of CuLs in natural seawater samples along a line from 56°N to 20°S, along 152°W through the north and central Pacific Ocean. The CuLs identified in laboratory cultures had molecular formulae and fragmentation patterns characteristic of linear tetrapyrroles, a group of organic compounds commonly found in biological systems. This identification was further supported by absorbance and nuclear magnetic resonance spectroscopy. The distribution of CuLs in the Pacific Ocean showed a highly dynamic and complex mixture of ligands, closely tied to biological cycles.
Effects of Downhill Running Exercise on Glucose Tolerance and Skeletal Muscle P-AMPK Expression in Type II Diabetes Rats
Authors: Park Sung-Tae
Published: May 2022

OBJECTIVES The purpose of this study was to investigate the effects of moderate downhill running exercise on glucose tolerance and skeletal muscle phospho-AMP activated protein kinase(P-AMPK) expression in type Ⅱ diabetes rats.METHODS 8-week-old, 24 wistar & GK rats (type Ⅱ diabetes model) were randomly divided into 4 groups, NR, NE, DR, DE. Downhill running treatment were performed on the treadmill at the -16 % and speed of 16m/min for 1 hour. All groups were done with Oral glucose tolerance test(OGTT) and after 1 week washout period, rats in exercise groups performed downhill running. After exercise treatment, soleus muscle of rats were extracted for test of P-AMPK expression.RESULTS In OGTT, blood glucose levels in all groups were increased after the oral glucose load and these were significantly differ from rest level. But in DE group, blood glucose level at 120 min after OGTT was not significantly differ from rest level. In immunoblotting test for P-AMPK expression of skeletal muscle, NE group was significantly higher than NR group and DE group was significantly higher than other groups.CONCLUSIONS Downhill running exercise improved glucose tolerance and increased P-AMPK expression of skeletal muscle in type Ⅱ diabetes rats.
Substantial Phase Exploration for Intuiting Covid using form Expedient with Variance Sensor
Authors: Chandan Radha Raman , Kshirsagar Pravin R. , Manoharan Hariprasath , El-Hady Khalid Mohamed , Islam Saiful , Khan Mohammad Shahiq , Chaturvedi Abhay
Published: May 2022

This article focuses on implementing wireless sensors for monitoring exact distance between two individuals and to check whether everybody have sanitized their hands for stopping the spread of Corona Virus Disease (COVID). The idea behind this method is executed by implementing an objective function which focuses on maximizing distance, energy of nodes and minimizing the cost of implementation. Also, the proposed model is integrated with a variance detector which is denoted as Controlled Incongruity Algorithm (CIA). This variance detector is will sense the value and it will report to an online monitoring system named Things speak and for visualizing the sensed values it will be simulated using MATLAB. Even loss which is produced by sensors is found to be low when CIA is implemented. To validate the efficiency of proposed method it has been compared with prevailing methods and results prove that the better performance is obtained and the proposed method is improved by 76.8% than other outcomes observed from existing literatures.
Analysis of a Public and Private Networks for Nutrient Measurement System using LoRawan Network
Authors: Perdana Doan , Ariateja Cahya , Alinursafa Ibnu , Cahyono Ongko
Published: May 2022

Lorawan network is ideal for IoT devices that continuously monitor a device and provide information to the gateway if the monitored data is outside the permitted threshold. These devices only require a small bandwidth and are therefore capable of operating on batteries for a long period of time. This study evaluates the design of a tool to measure soil nutrients with parameters of Nitrogen (N), Phosphorus (P), Potassium (K) using NPK sensors and IoT-based systems. The microcontroller used is ESP 32 which is connected to two types of networks. And will be integrated by Antares and the Android app. The purpose of making two types of networks in order to obtain data for analysis or development of the next tool. The result of designing this system is to create a device that can help farmers or the community in the process of measuring nitrogen, phosphorus, and potassium levels directly through the Android application so that soil control and fertilization can be more effective moreover yields can be maximized.
Covid-19 Patients’ Hospital Occupancy Prediction During the Recent Omicron Wave via some Recurrent Deep Learning Architectures
Authors: Bouhamed Heni , Hamdi Monia , Gargouri Rahma
Published: May 2022

This paper described a suggested model to predict bed occupancy for Covid-19 patients by country during the rapid spread of the Omicron variant. This model can be used to make decisions on the introduction or alleviation of restrictive measures and on the prediction of oxygen and health human resource requirements. To predict Covid-19 hospital occupancy, we tested some recurrent deep learning architectures. To train the model, we referred to Covid-19 hospital occupancy data from 15 countries whose curves started their regressions during January 2022. The studied period covers the month of December 2021 and the beginning of January 2022, which represents the period of strong contagion of the omicron variant around the world. The evolution sequences of hospital occupancy, vaccination percentages and median ages of populations were used to train our model. The results are very promising which could help to better manage the current pandemic peak.
O que o radiologista deve saber sobre o papel da gastrostomia percutânea: ensaio iconográfico
Authors: Tibana Tiago Kojun , Verza Leonardo , Rodrigues Bernardo Caetano da Silva , Monsignore Lucas Moretti , Abud Daniel Giansante , Nunes Thiago Franchi
Published: May 2022

Resumo As técnicas de gastrostomia guiadas por imagem, por via transoral e transabdominal podem ser realizadas quando há falha na técnica endoscópica ou em cenários clínicos em que a endoscopia não pode ser realizada. Este ensaio iconográfico pretende mostrar as técnicas de gastrostomia percutânea, suas indicações, aspectos técnicos, cuidados pós-procedimento e complicações.
Morbidity and mortality associated with fracture of the sternum due to blunt trauma, by fracture type and location
Authors: Şimşek Sadullah , Özmen Cihan Akgül , Onat Serdar
Published: May 2022

Abstract Objective: To examine the relationship that the types and locations of fractures of the sternum have with mortality and morbidity. Materials and Methods: We analyzed the records of 115 patients diagnosed with fracture of the sternum, due to blunt trauma, between 2007 and 2018. Records of computed tomography studies were obtained from the radiology archive of a tertiary teaching hospital. The type of fracture was classified as linear, displaced, or comminuted, whereas the fracture location was classified as the manubrium, body, or xiphoid process. Results: A total of 108 patients were included in the study. Of those patients, 92 (85.2%) were male and 16 (14.8%) were female. The etiology was a traffic accident in 72 cases (62.6%) and a fall from height in 36 (31.3%). The mean age was 42.1 ± 17.7 years for males and 53.9 ± 20.0 years for females. The mortality rate was 11.1%. Among the 12 deceased patients, the mean age was 44.4 ± 18.3 years. The fracture was located exclusively in the manubrium in 64 patients (59.3%), exclusively in the body of the sternum in 41 (38.0%), and in both locations in three (2.7%), whereas none were located in the xiphoid process. Morbidity rates were higher in the patients with fractures of the manubrium than in those with fractures of the body of the sternum, as was the incidence of accompanying bone fractures and organ injuries. The fracture was linear in 44 patients (40.7%), displaced in 62 (57.4%), and comminuted in 30 (27.8%). The mortality was significantly higher for comminuted fractures than for the other fracture types (p = 0.045; β = 4.40). Conclusion: Fracture of the manubrium can be indicative of the severity of trauma and has a poor prognosis.
Uterine artery embolization with highly compressible calibrated microspheres for the treatment of uterine fibroids
Authors: Szejnfeld Denis , Santos Rômulo Florêncio Tristão , Kambara Antonio Massamitsu , Colli Marcelo Bueno de Oliveira , Nasser Felipe , Martins Mauricio de Sena , Goldman Suzan Menasce
Published: May 2022

Abstract Objective: To evaluate the safety and efficacy of using highly compressible calibrated microspheres in uterine artery embolization (UAE) for the treatment of uterine fibroids. Materials and Methods: This was a prospective multicenter study. Thirty-two women with symptomatic uterine fibroids were selected for UAE between January 2019 and March 2020. The participants completed the Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire, underwent contrast-enhanced pelvic magnetic resonance imaging (MRI), and were submitted to anti-Müllerian hormone measurement, subsequently undergoing UAE with Embosoft microspheres. After six months, the patients again completed the UFS-QOL questionnaire and underwent pelvic MRI. Results: The most common symptoms were abnormal uterine bleeding (in 81.3% of the cases), pelvic pain (in 81.3%), and compression (in 46.9%). Of the 32 patients evaluated, 12 (37.5%) had anemia due to abnormal uterine bleeding. Thirty patients completed the study. Among those patients, we observed median reductions of 21.4% in uterine volume and 15.9% in dominant fibroid volume. We identified no adverse events that could be attributed to the material itself, although there were events attributed to the UAE procedure in general. Conclusion: For the treatment of uterine fibroids, UAE using Embosoft microspheres shows satisfactory results, providing reductions in uterine and dominant fibroid volumes, with a low rate of adverse events, and improving patient quality of life, as well as demonstrating safety and efficacy.
Situação de saúde mental de comunidades tradicionais: marcadores sociais em análise
Authors: Dimenstein Magda , Simoni Ana Carolina Rios , Macedo João Paulo , Liberato Mariana Tavares Cavalcanti , Silva Brisana Índio do Brasil de Macêdo , Prado Caio Lucas do Carno , Leão Mateus Villaroel Alcantara Saraiva
Published: May 2022

Objetiva-se analisar a situação de saúde mental de 48 municípios nordestinos que registram a presença de comunidades quilombolas e de assentamentos de reforma agrária em seus territórios, considerando as condições de vida, a oferta de serviços de saúde e o perfil de morbimortalidade em saúde mental. São articulados aspectos de gênero, classe e raça para compreender a produção de iniquidades em saúde nesses territórios. Trata-se de um estudo descritivo, realizado a partir de análise quantitativa com dados secundários coletados de diferentes bases disponíveis em domínio público. Observa-se o entrecruzamento e a combinação de fatores que influenciam a situação de saúde mental de municípios com populações do campo e da floresta: a precariedade nas condições de vida e trabalho, retaguarda insuficiente de serviços de atenção psicossocial e desigualdades étnico-raciais e de gênero da morbimortalidade psiquiátrica.
Vozes do além: uma análise psicopatológica da eclosão de experiências anômalas em médiuns espíritas
Authors: Furlanetto Danilo
Published: May 2022

As experiências anômalas (EA) são experiências psíquicas inusitadas, não necessariamente patológicas, que ocorrem em contextos espirituais e religiosos. Esse estudo explora o surgimento de EA, suas características e repercussões psíquicas, com base na análise qualitativa do relato autobiográfico de médiuns espíritas. Dez sujeitos foram selecionados e submetidos a um questionário sociodemográfico e a entrevista semiestruturada. As EA surgiram, majoritariamente, na infância e na adolescência dos entrevistados, sendo vagas e associadas a medo, ansiedade e falta de controle, muitas vezes, remetendo à “loucura”. Experiências alucinatórias de natureza visual, auditiva e tátil foram descritas de forma marcantemente heterogênea, indicando a importância dos componentes subjetivos e imaginativos, bem como sugerindo que a manifestação de vivências de natureza psicótica ocorra dentro de um campo dimensional complexo.
Affectivity and agency in English teaching for Youth and Adult Education
Authors: Satyro Diego
Published: May 2022

ABSTRACT This research addresses some links between affectivity and the agency of English language teachers, in the context of Youth and Adult Education. The literature review includes studies on affectivity from the perspective of Paulo Freire and on the articulation between agency and emotions. The research is a collective case study, whose context is based on two municipal public schools, located on the outskirts of São Bernardo do Campo (in São Paulo, Brazil). Two English language teachers who work in two junior high schools take part in the study. The investigation revealed three main findings: (1) affectivity facilitates the teaching-learning process of the English language; (2) teachers’ agency is influenced by conflicting emotions; and (3) there are differences between affectivity in agency and affectivity as agency.