bluuebunny/crossref_metadata_2025 huggingface dataset:
Overall Design of Multi-module Offshore Floating Bridge and a Method for Random Analysis of Anchor Tension
Authors: Lu Yi , Guo Jianting , Zhu Yiming , Zhu Shaowen
Published: August 2023

This paper proposes a multi-module floating bridge design for offshore applications and establishes a coupled motion response analysis method for the anchoring system of the floating bridge. Time-domain coupled analysis is performed under the combined effects of wind, wave, and current loads, resulting in the maximum tension of the anchor chain in random waves. Using the typical island and reef sea area of Zhoushan, China as an example, the randomness of waves is considered, and a random sampling method is adopted. The main configuration, connection structure, and mooring system design schemes are presented, and the maximum tension of the anchoring system is numerically calculated and analyzed. The random distribution of the maximum anchor chain tension is obtained, the goodness-of-fit test is conducted for the fitting results, and the main degree-of-freedom motion response is analyzed under different exceedance probabilities. The results show that the multi-module offshore floating bridge meets the design requirements, and the statistical characteristics of the maximum tension of the anchor chain under random waves conform to the Gumbel distribution. The mode of the random distribution of the maximum anchor chain tension increases by 7.65% when fully loaded compared to the unloaded condition. In different exceedance probability scenarios, there are significant differences in the maximum tension of the anchor chain and the motion response of the main degrees of freedom of the floating bridge.
Comparative Study and Analysis of Cryogenic Storage Tanks with Different Storage Energy Media
Authors: Yang Fan , Zhang Chao , Zhang Bochao
Published: August 2023

Liquefied natural gas (LNG), ethylene, ethane, propane, and other clean energy are often stored in a cryogenically frozen state on a large scale. As the core equipment of cryogenic energy storage tanks, if different cryogenic energy media are stored, there are certain differences in the design of the storage tanks. Although the design specifications differ little, there is a lack of systematic research. This paper compares the material, process, structure, construction, and commissioning of cryogenic storage tanks such as ethylene, ethane, propane, and LNG storage tanks, and studies the feasibility of replacing C2 and C3 refrigerated hydrocarbon storage tanks with LNG storage tanks. The results show that different refrigerated hydrocarbon storage tanks have common points in terms of design and construction standards, design processes, outer tanks, and cold insulation materials, while differences in internal tank materials, medium density, temperature, and other aspects lead to differences in technology, structure, construction, start-up, and commissioning. It is concluded that C2 cryogenic storage tank is theoretically feasible to replace with the LNG storage tank, while C3 cryogenic storage tank is not suitable to replace with the LNG storage tank due to the high design temperature of the inner tank material.
Numerical Study of Proppant Transport in Intersected Fractures for Supercritical Carbon Dioxide Fracturing
Authors: Liu Boyu , Yao Jun
Published: August 2023

This study employs Computational Fluid Dynamics (CFD) method to simulate particle transport in supercritical carbon dioxide fracturing. A dynamic leak-off model is integrated into the Eulerian-Eulerian two-fluid model. It systematically examines the transport of different-sized proppants in intersected fractures with leak-off and investigates the effects of proppant size, bypass fracture width, inter-fracture angle, and pumping schedule on the proppant distribution. Results show that the proppant split ratio increases with an increase in bypass fracture width and inter-fracture angle. Injecting larger-sized proppants before smaller-sized proppants can enhance the proppant bed length and height while reducing the proppant split ratio.
Numerical Simulation of Karst Collapse in Qingling Town, Wuhan
Authors: Chen Dongqin , Cao Yi
Published: August 2023

With background information on the geological conditions of Fenghuo village, Qingling town, Wuhan, based on Terzaghi consolidation theory and GMS software, a hydrodynamic-mechanics coupling model was established. On the basis of simulating the groundwater flow field by GMS software, a mechanical calculation program was developed, and the coupling simulation of hydrodynamic mechanics was achieved. The results showed that the stress state, vertical deformation, and damage of soil are closely related to the underground water flow. The soil pressure value and effective stress value are relatively low from July to August every year. It is the result of buoyancy produced by groundwater. Soil settlement generally occurs in the dry season. When the load is not considered, the deformation value of soil settlement is generally less than 6 mm. In the wet season from July to August every year, the soil will float up, and the floating value is less than 4 mm. The groundwater table changes frequently, and the destruction around the cave body eventually leads to karst collapse.
Measured Impedance Characteristic of T-connection Transmission Line with DG
Authors: Yang Shuqiang , Liu Yiqing , Zeng Fanyong
Published: August 2023

In Active Distribution Network (ADN), T-connection transmission lines are formed when Distributed Generations (DGs) are connected to transmission lines rather than to buses. In the T-connection transmission line with DG, the pilot current differential protection loses selectivity due to the change of fault current caused by T-type connection DG. Differential current increases to as much as the injected DG current when an external fault occurs, which results in maloperation. The impedance differential protection using measured impedance characteristics can effectively distinguish the fault location and is not affected by DG. However, the impedance differential protection is only studied under the condition that DG is connected to buses to study the impedance differential protection for the T-connection transmission line with DG, it is necessary to analyze the measured impedance characteristics of the T-connection transmission line with DG. This paper classifies fault locations and analyzes the measured impedance characteristics of three terminals under the condition of each type of fault location. The simulations verify the correctness of the impedance characteristic analysis.
Application of Quality Inspection Data Association Rules in Measurement Terminal Based on MapReduce
Authors: Zhang Bo , Liu Yongping , Xia Xin , He Chuanliang , Zhen Guolong , Xu Pu
Published: August 2023

To solve the problem of not being able to intuitively lock the cause of defects when processing massive quality inspection datasets with multiple batches, types, and models of measurement terminals, a MapReduce-based Apriori algorithm is proposed. After the MapReduce algorithm model calculation, the processing efficiency of the quality inspection dataset has been significantly improved. Through the multi-node calculation and analysis of the single-phase electricity meter quality inspection dataset and the application of association rule mining, reasonable suggestions were given, which improved the professional value and quality supervision level of the quality inspection business.
Coordinated Optimization of Distributed Wind Power and Electric Energy Storage Technologies
Authors: Dang Qi , Zhang Yuechao , Yang Wei , Wang Yongli , Zhao Zhonghua , Qiao Jing
Published: August 2023

The location and capacity of distributed wind power (DWG) and battery energy storage (BES) in the distribution network affect the operation of the distribution network. To improve the consumption capacity of wind power and reduce the impact of uncertainty of wind power output on the operation of the distribution network, the optimal allocation of DWG and BES should be coordinated in the planning stage. In this paper, the stochastic tide of the wind-storage system is used to reflect the operation status and uncertainty of the distribution network with DWG and BES, and the maximization of the integrated return of equal annual value is used as the objective function to establish the opportunity constrained planning model.
Decentralized frequency support control based on distributed PV’s adaptive power reserve
Authors: Zhu Chongxi , Xu Hong , Gu Leichun , Hua Zhiwei , Li Xin , Feng Qifan
Published: August 2023

High integration of PV diminishes system inertia, which jeopardizes the system frequency stability. Adjusting PVs’ output according to demand is an active power control method requiring no energy storage devices, which realizes grid frequency support by a certain reserved power of PV. To equally reserve power between different PVs without communication, this paper combines the operation characteristics of the PV module on the right side of the maximum power point and proposes the characteristic of power reserve and adaptive power reserve-frequency supporting control. Furthermore, irradiance and temperature sensors, cumbersome mathematical computation, and accurate measurement of PV module parameters can be eliminated. Finally, simulations are provided to validate the effectiveness of the proposed control strategy.
Adaptive Coordination Control Based on Alkaline Water Electrolyzers and Battery Driven by Wind Power
Authors: Zhu Chongxi , Xu Hong , Gu LeiChun , Hua Zhiwei , Li Xin , He Hanghang
Published: August 2023

With the widespread use of clean energy sources, there has been a growing interest in obtaining green and pure hydrogen from wind power. However, wind energy is characterized by randomness and volatility, which results in a low grid connection rate for wind turbines and makes it difficult to integrate wind energy into the power grid. In this context, this article proposes an adaptive coordinated control strategy considering the wind turbine, alkaline electrolyzer, battery, and local loads. Using the DC bus voltage as the connecting signal, adaptive power control and voltage control methods are developed for the wind turbine, energy storage battery, and electrolyzer to achieve power matching in the system. Finally, the proposed research results are validated through Matlab/Simulink simulation module.
Application of Uncertainty Analysis in Distributed Planning of Urban Comprehensive Energy System
Authors: Yao Xueheng , Peng Yangjie , Li Lifan , Li Wenjing , Mao Xuyu
Published: August 2023

The conventional distributed planning method of urban integrated energy systems uses the LINMAP coupling model to obtain the optimal solution of planning, which is vulnerable to the impact of decision-making load demand, resulting in the final annual value of energy planning costs being too high. Therefore, it is necessary to design a new distributed planning method for urban integrated energy systems based on uncertainty analysis. Based on the analysis of uncertain factors, the mathematical model of equipment planning of the energy system is constructed, and combined with the energy storage relationship, the distributed planning operation algorithm of the integrated energy system is designed, thus completing the distributed planning of the integrated energy system. The experimental results show that the annual value of energy planning cost of different system equipment is low after using the designed distributed planning method of urban integrated energy systems based on uncertainty analysis, which proves that the designed distributed planning method has good planning effect, economy and certain application value, and has made certain contributions to reducing energy planning loss.
Control of isolated hydrogen generation power supply for the DC power grid
Authors: Teng Zhichu , Ji Mengbo , lv Chengcheng , Qian Xiangyi , Gui Jixiang , Zhang Jie
Published: August 2023

The utilization of water electrolysis hydrogen in DC power grids can effectively improve the absorption and utilization of renewable energy, and hydrogen production power supply is a key equipment. This article designs an isolated DC hydrogen production power supply, which adopts a bidirectional active H-bridge topology and power modular design. In the process of hydrogen production, the use of constant current and constant voltage control, the development of control strategies for the hydrogen production process but the input current ripple of the electrolytic cell is heavy, so the driving pulse interleaving phase shift between power modules is adopted. The hydrogen production power supply can achieve a hydrogen production process with a small current ripple, and the feasibility and effectiveness of the hydrogen preparation power supply control strategy have been verified through simulation and experiments.
Low-Frequency Defense Strategy for Wind Turbine Participating in Power Grid Frequency Adjustment
Authors: Feng Yuexin , Ye Peng , Yin Yuanke , Hu Shubo , Ma Xintong , Fu Rao
Published: August 2023

With the continuous increase of wind power permeability, the dynamic behavior of the power system also changes, which also has a great impact on the setting of the low-frequency load-shedding scheme. The original low-frequency load-shedding scheme has no good adaptability to the system of high-permeability wind power. So, this article analyzes the principles of wind turbines in power grid frequency control. This paper expounds on the principle of low-frequency load-shedding strategy in the power system configuration. Connecting with the actual operation of the grid simulation, simulation results show that wind turbines in power grid frequency modulation can significantly reduce the low-frequency load shedding process of loads and wind power in frequency modulation of low-frequency with a positive impact.
Big data-based method for automatic localization of power quality disturbance signal of PV access distribution network
Authors: Tang Zhen , Han Jing , Wang ShiJian , Ding Li , Zhu YiChao
Published: August 2023

At present, the conventional automatic localization method of the power quality disturbance signal of the distribution network mainly extracts the feature vector of the disturbance signal. It constructs the target localization function, which leads to poor localization accuracy because the noise part of the disturbance signal is ignored. In this regard, the automatic localization method of PV access power quality disturbance signal based on big data is proposed. By using the wavelet decomposition algorithm, the noise part of the power quality disturbance signal is removed, and the measurement matrix and reconstruction function are combined with compressing and reconstructing the disturbance signal. Finally, the automatic positioning of the disturbance signal is achieved by extracting the characteristics of the disturbance signal data and clustering analysis processing. In the experiment, the designed signal localization method is tested for the localization effect. The results can prove that when the proposed method is used to automatically localize the disturbed signal, the localization results are consistent with the spatial feature distribution of the signal and have a more desirable automatic localization effect.
Analysis of the Very Fast Transient Overvoltage in a Nuclear Plant 500kV GIL-GIS System
Authors: Yin Hong , Li Chunbo , Zhang Linkang , Liu Shourui , Ma Qing , Wang Qihang
Published: August 2023

The simulation models of the 500kV gas-insulated transmission lines (GIL) and gas-insulated substation (GIS) systems in a realistic nuclear plant are presented in the paper. The Very Fast Transient Overvoltage (VFTO) which is generated during switching operations, is analyzed. Some affecting factors on the level of the VFTO are investigated. These factors are the location of the power source, the entrance capacitance of the potential transformer (PT), and the capacitive voltage transformer (CVT). At last, some suggestions on overvoltage calculations or calculations of electromagnetic interference sources are proposed. The conclusions can be used in insulation designing and analyzing the electromagnetic interference on the secondary system in nuclear plants and substations.
Automatic fault location method for power communication network based on a machine learning algorithm
Authors: Li Guoqiang , Ren Chunlei , Chen Zhefu
Published: August 2023

The current conventional automatic fault location method of power communication network mainly realizes the identification of faulty branches by calculating node power parameters, which leads to poor location effects due to the lack of effective analysis of fault signal data. In this regard, the automatic fault location method of the store head communication network based on a machine learning algorithm is proposed. Firstly, the fault signal data are collected and pre-processed, specifically including data cleaning and data format conversion, and then the individual fault signal is used as the basis to differentiate the weight parameters of different abnormal degrees and combine with the state threshold to realize the judgment of the fault node interval location. In the experiments, the fault location performance of the proposed method is verified. The experimental results show that when the proposed method is used for fault location, the relative positioning error value of the method is small and has a high fault location accuracy.
Sequentially suspended 3D bioprinting of multiple-layered vascular models with tunable geometries for in vitro modeling of arterial disorders initiation
Authors: Pan Chen , Xu Jingwen , Gao Qiqi , Li Wei , Sun Tao , Lu Jiping , Shi Qing , Han Yafeng , Gao Ge , Li Jinhua
Published: August 2023

As the main precursor of arterial disorders, endothelial dysfunction preferentially occurs in regions of arteries prone to generating turbulent flow, particularly in branched regions of vasculatures. Although various diseased models have been engineered to investigate arterial pathology, producing a multiple-layered vascular model with branched geometries that can recapitulate the critical physiological environments of human arteries, such as intercellular communications and local turbulent flows, remains challenging. This study develops a sequentially suspended three-dimensional bioprinting (SSB) strategy and a visible-light-curable decellularized extracellular matrix bioink (abbreviated as ‘VCD bioink’) to construct a biomimetic human arterial model with tunable geometries. The engineered multiple-layered arterial models with compartmentalized vascular cells can exhibit physiological functionality and pathological performance under defined physiological flows specified by computational fluid dynamics simulation. Using different configurations of the vascular models, we investigated the independent and synergetic effects of cellular crosstalk and abnormal hemodynamics on the initiation of endothelial dysfunction, a hallmark event of arterial disorder. The results suggest that the arterial model constructed using the SSB strategy and VCD bioinks has promise in establishing diagnostic/analytic platforms for understanding the pathophysiology of human arterial disorders and relevant abnormalities, such as atherosclerosis, aneurysms, and ischemic diseases.
Enhancement of electron magnetic susceptibility due to many-body interactions in monolayer MoSe2
Authors: Oreszczuk K , Rodek A , Goryca M , Kazimierczuk T , Raczyński M , Howarth J , Taniguchi T , Watanabe K , Potemski M , Kossacki P
Published: August 2023

Employing the original, all-optical method, we quantify the magnetic susceptibility of a two-dimensional electron gas (2DEG) confined in the MoSe2 monolayer in the range of low and moderate carrier densities. The impact of electron–electron interactions on the 2DEG magnetic susceptibility is found to be particularly strong in the limit of, studied in detail, low carrier densities. Following the existing models, we derive the value of

g
0

=
2.5
±
0.4

for the bare (in the absence of the interaction effects) g-factor of the ground state electronic band in the MoSe2 monolayer. The derived value of this parameter is discussed in the context of estimations from other experimental approaches. Surprisingly, the conclusions drawn differ from theoretical ab initio studies.
Impact of increased subway station density on air quality in the Yangtze River Delta
Authors: Ye Xiaohui , Sato Masayuki
Published: August 2023

This study uses empirical methods to explore the relationship between subway system development and air quality in the Yangtze River Delta. We propose a new variable to measure subway development, ‘subway station density value,’ which can more accurately describe subway development than the traditional ‘line opening’ variable. It eliminates the effects of differences in subway line length, layout, and size of the local subway system. Using this variable, we find that subway development has a significant positive impact on air quality improvement; that is, an increase in the density of subway stations is significantly associated with improved air quality. This finding provides a scientific basis for the relevant authorities to formulate the development and layout of public transport facilities. It strongly responds to previous debates on the relationship between subways and air quality. In addition, we find that urban population size, economic development level, and subway system size play moderating roles in the relationship between subways and air quality. Increasing the availability of subways can significantly improve the air quality in cities with high population sizes and economic development levels. However, as the size of a subway system increases, its effect on air quality improvement may weaken, suggesting that the development of subway systems should not be unthinkingly expanded either. Although our study has valuable findings, we must discuss several limitations further. These include restrictions in the selection of the study population, data availability, and potentially oversimplified criteria for considering the impact of urban differences. Overall, this study not only provides new theoretical and empirical perspectives for understanding and explaining how subway development affects air quality but also indicates the direction for further exploration in future studies.
Climate change emergence over people’s lifetimes
Authors: King Andrew D , Douglas Hunter , Harrington Luke J , Hawkins Ed , Borowiak Alexander R
Published: August 2023

The emergence of climate change from background variability is a useful metric for identifying changes in local climate which may affect people and ecosystems. Studies have found that equatorial regions, which are typically poorer, experience clearer climate change emergence over the observational record and in model projections. Here, we perform the first analysis of people’s experienced climate change relative to background variability, and we examine where people have already lived through an emergence of local warming. We calculate signal-to-noise (S/N) ratios and combine these with demographic data to compute local emergence of warming over human lifetimes. Younger people have typically experienced less clear emergence of a climate change signal over their lifetimes to date. Over a given time period, tropical, lower-income areas have experienced higher S/N than extratropical and typically higher-income areas. However, this is counter-balanced by the younger populations of these areas such that the median experienced S/N ratio is similar between the wealthiest and poorest parts of the world. Given projected ageing of low-income regions, it is imperative that substantial climate action is taken to avoid local climates becoming unrecognizable within human lifetimes.
Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis
Authors: Odiba Arome Solomon , Liao Guiyan , Ezechukwu Chiemekam Samuel , Zhang Lanlan , Hong Ye , Fang Wenxia , Jin Cheng , Gartner Anton , Wang Bin
Published: August 2023

Melanoma antigen (MAGE) genes encode for a family of proteins that share a common MAGE homology domain. These genes are conserved in eukaryotes and have been linked to a variety of cellular and developmental processes including ubiquitination and oncogenesis in cancer. Current knowledge on the MAGE family of proteins mainly comes from the analysis of yeast and human cell lines, and their functions have not been reported at an organismal level in animals. Caenorhabditis elegans only encodes 1 known MAGE gene member, mage-1 (NSE3 in yeast), forming part of the SMC-5/6 complex. Here, we characterize the role of mage-1/nse-3 in mitosis and meiosis in C. elegans. mage-1/nse-3 has a role in inter-sister recombination repair during meiotic recombination and for preserving chromosomal integrity upon treatment with a variety of DNA-damaging agents. MAGE-1 directly interacts with NSE-1 and NSE-4. In contrast to smc-5, smc-6, and nse-4 mutants which cause the loss of NSE-1 nuclear localization and strong cytoplasmic accumulation, mage-1/nse-3 mutants have a reduced level of NSE-1::GFP, remnant NSE-1::GFP being partially nuclear but largely cytoplasmic. Our data suggest that MAGE-1 is essential for NSE-1 stability and the proper functioning of the SMC-5/6 complex.
Loneliness and Social Network Characteristics Among Older Adults With Hearing Loss in the ACHIEVE Study
Authors: Huang Alison R , Reed Nicholas S , Deal Jennifer A , Arnold Michelle , Burgard Sheila , Chisolm Theresa , Couper David , Glynn Nancy W , Gmelin Theresa , Goman Adele M , Gravens-Mueller Lisa , Hayden Kathleen M , Mitchell Christine , Pankow James S , Pike James Russell , Sanchez Victoria , Schrack Jennifer A , Coresh Josef , Lin Frank R ,   for the ACHIEVE Collaborative Research Group, Galasko Doug , Buring Julie , Dubno Judy , Greene Tom , Lustig Larry
Published: August 2023

Background

Hearing loss is linked to loneliness and social isolation, but evidence is typically based on self-reported hearing. This study quantifies the associations of objective and subjective hearing loss with loneliness and social network characteristics among older adults with untreated hearing loss.

Methods

This study uses baseline data (N = 933) from the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) study. Hearing loss was quantified by the better ear, speech-frequency pure tone average (PTA), Quick Speech-in-Noise test, and hearing-related quality of life. Outcomes were validated measures of loneliness and social network characteristics. Associations were assessed by Poisson, negative binomial, and linear regression adjusted for demographic, health, and study design characteristics.

Results

Participants were mean of 76.8 (4.0) years, 54.0% female, and 87.6% White. Prevalence of loneliness was 38%. Worse PTA was associated with a 19% greater prevalence of moderate or greater loneliness (prevalence ration [PR]: 1.19.95% CI: 1.06, 1.33). Better speech-in-noise recognition was associated with greater social network characteristics (eg, larger social network size [IRR: 1.04, 95% CI: 1.00, 1.07]). Worse hearing-related quality of life was associated with a 29% greater prevalence of moderate or greater loneliness (PR: 1.29, 95% CI: 1.19, 1.39) and worse social network characteristics (eg, more constricted social network size [IRR: 0.96, 95% CI: 0.91, 1.00]).

Conclusions

Results suggest the importance of multiple dimensions of hearing to loneliness and social connectedness. Hearing-related quality of life may be a potentially useful, easily administered clinical tool for identifying older adults with hearing loss associated with greater loneliness and social isolation.
An Autoethnography of Hybrid IR Scholars: De-Territorializing the Global IR Debate
Authors: Karkour Haro L , Vieira Marco
Published: August 2023

Who can speak from the perspective of the Global South? In answering this question, Global International Relations (IR) finds itself in a cul de sac: rather than globalize IR, Global IR essentializes non-Western categories by associating difference and knowledge to place (countries, regions, and civilizations) which occludes de-territorialized forms of knowledge production. To reach out for these forms of knowledge, we develop the concept of “hybrid subjectivity,” and propose a shift from the macro to the micro. We propose autoethnography as a method to proceed with this move and present two case studies based on our experiences as hybrid IR scholars to illustrate it. In doing so, we demonstrate the relevance of our self-reflexive exercise in deconstructing reified categories and rendering visible new forms of knowledge in the Global IR debate. This article’s conceptualization of hybrid subjectivity enables the recasting of Global IR in a relational, hybrid, and truly global framework for analysis. The argument goes beyond the confines of Global IR and adds essential analytical value to critical, decolonial, and pluriversal critiques of wester-centrism in IR; in the sense of opening new theoretical and empirical possibilities, as an alternative to current intellectual efforts to recover non-colonial or pre-colonial forms of non-Western authenticity.
Integrating row level security in i2b2: segregation of medical records into data marts without data replication and synchronization
Authors: Scheible Raphael , Thomczyk Fabian , Blum Marco , Rautenberg Micha , Prunotto Andrea , Yazijy Suhail , Boeker Martin
Published: August 2023

Objective

i2b2 offers the possibility to store biomedical data of different projects in subject oriented data marts of the data warehouse, which potentially requires data replication between different projects and also data synchronization in case of data changes. We present an approach that can save this effort and assess its query performance in a case study that reflects real-world scenarios.

Material and Methods

For data segregation, we used PostgreSQL’s row level security (RLS) feature, the unit test framework pgTAP for validation and testing as well as the i2b2 application. No change of the i2b2 code was required. Instead, to leverage orchestration and deployment, we additionally implemented a command line interface (CLI). We evaluated performance using 3 different queries generated by i2b2, which we performed on an enlarged Harvard demo dataset.

Results

We introduce the open source Python CLI i2b2rls, which orchestrates and manages security roles to implement data marts so that they do not need to be replicated and synchronized as different i2b2 projects. Our evaluation showed that our approach is on average 3.55 and on median 2.71 times slower compared to classic i2b2 data marts, but has more flexibility and easier setup.

Conclusion

The RLS-based approach is particularly useful in a scenario with many projects, where data is constantly updated, user and group requirements change frequently or complex user authorization requirements have to be defined. The approach applies to both the i2b2 interface and direct database access.
Alterations in Ferrisia gilli (Hemiptera: Pseudococcidae) phenology in California pistachios and potential impacts on controls
Authors: Mercer Nathan H , Stahl Judith M , Daane Kent M
Published: August 2023

The mealybug, Ferrisia gilli Gullan, attacks important crops such as almonds, grapes, and pistachios in California. In pistachios, F. gilli has 3 generations per year, and a single insecticide application timed to the presence of first instars of the first or second generation provided sufficient control. This strategy has, recently, become less effective, and here we tested the possible explanation that F. gilli life stages are smeared, with different life stages present concurrently, reducing the efficacy of a single pesticide application. We monitored F. gilli populations and their natural enemies in central California pistachio orchards from 2021 through 2022. We found the first generation of F. gilli was synchronous, but occurred 3 wk earlier than previously reported. Subsequent generations were smeared. Increased yearly temperatures are a likely explanation for the changes observed in phenology. Almost all natural enemies found were lacewings (n > 10,000). Parasitoids were recovered from pistachios in 2021 (n = 4) and 2022 (n = 164), most were hyperparasitoids. Based on these studies, recommendations are made to monitor F. gilli in early May rather than late May to better target insecticide applications for the first instars.
Speaking Rights to Populism? Using Emotion as the Language of Values
Authors: Hamilton Claire
Published: August 2023

Since 2016 a series of unexpected developments such as Brexit and the shock election of Donald Trump have drawn attention to the rise of populism as one of the most significant phenomena in today’s political world. This populist ‘explosion’ is widely regarded as a significant threat to democracy and human rights, particularly the rights of minorities. So how should the human rights movement best respond? Speaking to the special issue theme on the meaning of and challenges to human rights, this article advances an argument for human rights claims-makers to learn the ‘lessons from populism’ in terms of its emotional appeal. Part 1 reviews the scholarly literature on human rights and the phenomenon of radical right populism to date, including the co-option of rights language by the far right. Part 2 builds on this literature to identify weaknesses in the legalistic way that (political) rights claims are advanced and argues that constructivist perspectives on rights may help ‘speak rights to’ populism. The final part argues that further research into emotions as the ‘language of values’ may help put empirical and conceptual flesh on the bones of a more ‘constructivist’ view of human rights.
Genetic analysis of TMPRSS6 catalytic domain variants in Mexican patients with iron treatment refractoriness
Authors: Hernández-Peña Rubiceli , Maciel-Cruz Eric Jonathan , Rizo-De La Torre Lourdes Del Carmen , Perea-Díaz Francisco Javier , Ibarra-Cortés Bertha
Published: August 2023

Objective

To identify the TMPRSS6 gene variants in Mexican patients with iron treatment refractoriness, to describe hematological and iron profile parameters, and to use bioinformatic prediction and protein modeling tools to assess a possible biological impact for the detected missense variants.

Methods

Nineteen patients referred with iron treatment refractoriness were studied. Peripheral blood was collected to determine hematic cytometry, iron profile, hemoglobin electrophoresis, and quantification. Molecular screening was carried out for exons 15 through 18 of the TMPRSS6 gene by Sanger sequencing and for frequent thalassemia variants by amplification-refractory mutation system-polymerase chain reaction (PCR) and gap-PCR. The biological impact of the detected missense variants was assessed using bioinformatic prediction and protein modeling tools.

Results

We found 5 genetic variants in the matriptase-2 catalytic domain: 1 at intron-15/exon-16 junction (rs60484081) and 4 exonic, 3 missense (rs377054987, p.Gly626Asp; rs1384127820, p.Ser672Thr; rs855791, p.Val727Ala) and 1 synonymous (rs2235321, p.Tyr730=), with frequencies ranging from 0.18 to 0.53. No significant differences were observed in the hematological parameters or iron profile, considering type and number of variants. Bioinformatic predictions suggested a possible biological impact only for rs377054987.

Conclusions

The TMPRSS6 variants observed in Mexican patients with oral iron treatment refractoriness have high frequencies; nevertheless, their relationship with hematological and iron profile parameters needs further research. The possible biological impact for rs377054987 is due to size and amino acid hydrophobicity changes and hydrogen bond modifications.
Endogenous μ-opioid—Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice
Authors: Nelson Tyler S , Santos Diogo F S , Prasoon Pranav , Gralinski Margaret , Allen Heather N , Taylor Bradley K
Published: August 2023

Tissue injury creates a delicate balance between latent pain sensitization (LS) and compensatory endogenous analgesia. Inhibitory G-protein-coupled receptor (GPCR) interactions that oppose LS, including μ-opioid receptor (MOR) or neuropeptide Y Y1 receptor (Y1R) activity, persist in the spinal cord dorsal horn (DH) for months, even after the resolution of normal pain thresholds. Here, we demonstrate that following recovery from surgical incision, a potent endogenous analgesic synergy between MOR and Y1R activity persists within DH interneurons to reduce the intensity and duration of latent postoperative hypersensitivity and ongoing pain. Failure of such endogenous GPCR signaling to maintain LS in remission may underlie the transition from acute to chronic pain states.
Getting ready for prime time: Recommended adaptations of an Empathic Communication Skills training intervention to reduce lung cancer stigma for a national multi-center trial
Authors: Banerjee Smita C , Malling Charlotte D , Shen Megan J , Williamson Timothy J , Bylund Carma L , Studts Jamie L , Mullett Timothy , Carter-Bawa Lisa , Hamann Heidi A , Parker Patricia A , Steliga Matthew , Feldman Jill , Pantelas Jim , Borondy-Kitts Andrea , Rigney Maureen , King Jennifer C , Fathi Joelle T , Rosenthal Lauren S , Smith Robert A , Ostroff Jamie S
Published: August 2023

Building upon prior work developing and pilot testing a provider-focused Empathic Communication Skills (ECS) training intervention, this study sought feedback from key invested partners who work with individuals with lung cancer (i.e. stakeholders including scientific and clinical advisors and patient advocates) on the ECS training intervention. The findings will be used to launch a national virtually-delivered multi-center clinical trial that will examine the effectiveness and implementation of the evidence-based ECS training intervention to reduce patients’ experience of lung cancer stigma. A 1-day, hybrid, key invested partners meeting was held in New York City in Fall 2021. We presented the ECS training intervention to all conference attendees (N = 25) to seek constructive feedback on modifications of the training content and platform for intervention delivery to maximize its impact. After participating in the immersive training, all participants engaged in a group discussion guided by semi-structured probes. A deductive thematic content analysis was conducted to code focus group responses into 12 distinct a priori content modification recommendations. Content refinement was suggested in 8 of the 12 content modification themes: tailoring/tweaking/refining, adding elements, removing elements, shortening/condensing content, lengthening/extending content, substituting elements, re-ordering elements, and repeating elements. Engagement and feedback from key invested multi-sector partner is a valuable resource for intervention content modifications. Using a structured format for refining evidence-based interventions can facilitate efforts to understand the nature of modifications required for scaling up interventions and the impact of these modifications on outcomes of interest.

ClinicalTrials.gov Identifier: NCT05456841.
Development of Rapid and Affordable Virus-Mimicking Artificial Positive Controls
Authors: Singh Shivani , Stainton Daisy , Tzanetakis Ioannis E.
Published: August 2023

A major bottleneck in the development of detection assays is the availability of positive controls. Their acquisition can be problematic, their maintenance is expensive, and without them, assays cannot be validated. Herein, we present a novel strategy for the development of virus-mimicking artificial positive controls (ViMAPCs). The time between design and application is less than 5 days, unlike alternatives which normally take several weeks to obtain and implement. The ViMAPCs provide a realistic representation of natural infection unlike alternatives and allow for an effortless recognition of laboratory-based contamination. The feasibility and adaptability of the strategy was evaluated using several RNA and DNA plant viruses. ViMAPCs can be used in diagnostics laboratories but also in the monitoring of pathogen outbreaks where rapid response is of utmost importance.
Successful continuance of CDK4/6 inhibitor treatment with palbociclib after abemaciclib-induced hepatotoxicity in breast cancer: a case report
Authors: Ozawa Yuki , Fujimiya Tatsuhiro , Shimada Akihiko , Okazawa Akira , Kusano Junichi , Yamamoto Ryusei , Hyasashi Seiichi
Published: August 2023

Abemaciclib, a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, causes severe hepatotoxicity, a severe adverse event associated with the loss of treatment opportunities. We report a case of liver injury (grade 4) during treatment with abemaciclib, in which the patient was switched to palbociclib and successfully treated with this CDK4/6 inhibitor. A 73-year-old woman with bone metastatic breast cancer (hormone-positive, HER2-negative) was treated with abemaciclib, fulvestrant, denosumab, and precipitated calcium carbonate with cholecalciferol and magnesium carbonate (pCCCM). On day 17, the patient developed skin rashes on her trunk and arms. On day 22, abemaciclib and pCCCM were discontinued due to drug eruption. Grade 3 aspartate aminotransferase (AST) and grade 4 alanine aminotransferase (ALT) levels increased on day 29. Therefore, fulvestrant and denosumab were suspended as the causes of severe hepatotoxicity, in addition to the two drugs suspected of causing the skin eruption. On day 43, AST and ALT levels did not improve, and the patient was referred to a hepatologist. The hepatologist diagnosed hepatotoxicity as a drug-induced liver injury through additional tests and interviews. Fulvestrant treatment was resumed on day 78, and palbociclib on day 92, and denosumab and pCCCM on day 134. On day 287, treatment with the CDK4/6 inhibitor was continued without evidence of liver dysfunction. This case suggests that rechallenge with palbociclib after severe liver injury with abemaciclib may allow for continued treatment with CDK4/6 inhibitors.
Exploring Nursing Care for Patients With COVID-19 Using International Classification for Nursing Practice–Based Nursing Records
Authors: Sung Sumi , Jung Hyesil , Kim Youlim
Published: August 2023

This study explored nursing care topics for patients with the coronavirus disease 2019 admitted to the wards and intensive care units using International Classification for Nursing Practice–based nursing narratives. A total of 256630 nursing statements from 555 adult patients admitted from December 2019 to June 2022 were extracted from the clinical data warehouse. The International Classification for Nursing Practice concepts mapped to 301 unique nursing statements that accounted for the top 90% of all cumulative nursing narratives were used for analysis. The standardized number of nursing statements for each concept was calculated according to the types of nursing care and compared between the two groups. The most documented topics were related to infection; physical symptoms such as sputum, cough, dyspnea, and shivering; and vital signs including blood oxygen saturation and body temperature. Nurses in the intensive care units frequently documented concepts related to the directly monitored and assessed physical signs such as consciousness, pupil reflex, and skin integrity, whereas nurses in wards documented more concepts related to symptoms patients complained. This study showed that the International Classification for Nursing Practice–based nursing records can be used as source of information to identify nursing care for patients with coronavirus disease 19.
Nurse Practitioner Regulatory Assessment
Authors: Tuden Danica , Secong Darlene , Wainwright Alison
Published: August 2023

The Nurse Practitioner Onsite Peer Review is an integral part of the British Columbia College of Nurses and Midwives Quality Assurance program. Traditionally an in-person assessment, Nurse Practitioner Onsite Peer Review involves a critical review of documentation by an experienced nurse practitioner assessor against regulatory standards and entry-level competencies. The onset of the COVID-19 pandemic and resulting environmental limitations required the college to rethink its approach to onsite reviews, resulting in the quality assurance program embarking on a pilot project to explore the feasibility of conducting reviews virtually. As there are many factors that can affect the transition of an onsite assessment to one that is virtual, it was important to consider the technical, workflow, and usability aspects in developing this new method of performance assessment. Therefore, including usability testing and a human factors approach to exploring this emerging method was vital to ensuring its success. In this article, we discuss our experience, including benefits, technical and administrative considerations, barriers, challenges, and lessons learned.
Dietary-induced binge-like eating impairs acoustic startle responses to acute nisoxetine in male mice
Authors: Scarpa Lori L. , Bello Nicholas T.
Published: August 2023

Sensorimotor gating disruptions have been noted in several psychiatric and neurodegenerative disorders. However, the involvement of sensorimotor gating processes in eating disorders has not been well characterized. Our objective was to examine the sensorimotor gating of the acoustic startle response following dietary-induced binge eating and high-fat diet (HFD) induced weight gain in male C57B/6J mice. Acute administration of the norepinephrine reuptake inhibitor, nisoxetine (0.5 and 5 mg/kg), and a dopamine reuptake inhibitor, GBR 12783 (1.6 and 16 mg/kg), were either given alone or in combination to assess norepinephrine and dopamine alterations, respectively. Male mice with repeated bouts of calorie restriction (Restrict) and with limited access to a sweetened fat food (Binge) demonstrated an escalation of intake over 2.5 weeks under standard chow conditions. Restrict Binge (RB) mice had a reduced startle response to the startle pulse (110 dB) compared with the Naive control group at 5 mg/kg nisoxetine. There was an overall effect of nisoxetine (0.5 and 5 mg/kg) to increase percent inhibition at pre-pulse (74 dB), %PP74. Under HFD conditions, the RB group did not demonstrate a binge-like eating phenotype. The RB group on HFD had a higher response to 74 dB with nisoxetine (5.0 mg/kg) compared with a combinational dose of nisoxetine (5.0 mg/kg) and GBR 12783 (1.6 mg/kg). These findings suggest that dietary conditions that promote binge-like eating can influence the central noradrenergic and dopaminergic controls of the acoustic startle response and potentially influence sensorimotor gating.