bluuebunny/crossref_metadata_2025 huggingface dataset:
Utländska spelare i allsvenskan 1974–2021. Globalisering, kommersialisering och migration
Authors: Hellström John S. , Kendrick Rhidian
Published: October 2023

Since the late 1990s, professional football players moving across national borders in search of the best possible livelihoods constitute a form of transnational labour migration that has grown enormously in scale and scope. The Swedish Premier Division has gradually been incorporated into this global player market. The development began in 1974, when Swedish clubs for the first time were allowed to sign foreign players. However, it was only after the Bosman-ruling in 1995, and the removal of restrictions on the number of foreign players, that the league was forcefully globalized. In this article, this globalizing development between 1974 and 2019 is analysed. The study shows that the development took place in three different phases, with the last phase (2009-19) constituting a break in the trend in globalization. From this point on, the number of players from countries in the nearby geographical area increased rapidly.
Isak Lidström, På skidor i kulturella gränsland: Samiska spår i skidsportens historia, Malmö Universitet (2021)
Authors: Pedersen Helge Chr.
Published: October 2023

.
Evaluasi Kesesuaian Switch Therapy Antibiotik Pada Pasien Bedah di Rumah Sakit Pusri Palembang
Authors: Amelia Kiki , Nur Indah Sari Ina , Rusli Doddy
Published: October 2023

Switch therapy adalah pergantian terapi antibiotik intravena ke oral. Penelitian ini bertujuan untuk mengetahui kesesuaian switch therapy antibiotik pada pasien bedah dan mengetahui gambaran pemilihan antibiotik intravena dan oral yang digunakan pada pasien bedah. Penelitian ini merupakan penelitian deskriptif dan data diambil secara retrospektif yang berasal dari data rekam medik pasien. Hasil penelitian ini menunjukkan bahwa terdapat 80 pasien yang memenuhi kriteria inklusi, sefotaksim merupakan antibiotik intravena yang paling banyak digunakan yaitu 53,57%, dan antibiotik oral yang paling banyak digunakan adalah moksifloksasin sebanyak 30%. Persentase pasien bedah yang memenuhi kriteria switch therapy yaitu suhu tubuh sebanyak 64 pasien (80%), RR terdapat 65 pasien (81,25%), denyut nadi terdapat 64 pasien (80%), pemeriksaan nilai leukosit sebanyak 73 pasien (91,25%). Disimpulkan bahwa pasien bedah di Rumah Sakit Pusri Palembang periode Januari-Maret 2020 telah memenuhi kriteria kesesuaian switch therapy berdasarkan Kemenkes 2020
Pengujian Evaluasi Mutu Tablet Dexametason Generik Dan Merek Dagang
Authors: Putra Teguh Adiyas , Epiyawati Devi , Putri Ghefira Aulia , Nurlutfia Deby
Published: October 2023

Dexametason merupakan glukokortikoid yang sangat poten, seringkali digunakan untuk menekan inflamasi, alergi dan respon imun. Terapi anti inflamasi digunakan pada banyak penyakit. Supresi sistem imun bermanfaat dalam mencegah penolakan  setelah transplantasi jaringan, selain itu glukortikoid juga digunakan untuk menekan limfopoiesis pada pasien dengan leukemia dan limfoma tertentu. Beberapa faktor dapat berpengaruh dalam kecepatan melarutnya suatu obat dari sediaan tablet, yang berdampak pada ketersediaan hayatinya, antara lain ukuran kristal zat aktif, mekanisme dan kecepatan hancurnya tablet, metode granulasi, jenis dan jumlah penggranul, jenis, jumlah dan metode inkorporasi zat penghancur dan pelincir, proses dan formulasinya. Sehingga untuk mendapatkan efek farmakologois yang optimal diperlukan upaya pengevaluasian tablet dexamethasone 0,5 mg dan kalmethasone 0,5 mg agar dapat memenuhi standar Industri Farmasi dan persyaratan Farmakope Indonesia.
OPTIMASI FORMULA BLUSH ON CREAM MENGGUNAKAN PEWARNA ALAMI EKSTRAK WORTEL (Daucus carota L) DENGAN METODE FACTORIAL DESIGN
Authors: Alta Ulik , Pratiwi Galih , Arina Yudi
Published: October 2023

Latar Belakang : Wortel merupakan salah satu tumbuhan yang berkhasiat dan memiliki banyak manfaat, wortel mengandung vitamin A, C, dan vitamin K  serta betakaroten. Beta-karoten adalah jenis pigmen yang ditemukan dalam tanaman yang dapat digunakan sebagai zat pewarna. Tujuan :  Untuk mendapatkan komposisi optimal dari  beeswax, isoprofil miristat dalam formula blush on cream wortel. Metode : Penelitian ini adalah metode eksperiment laboratorium dengan menggunakan pendekatan design of experiment (DoE) menggunakan piranti lunak design expert dengan factorial design 22 dengan uji ANOVA. Parameter yang diuji meliputi organoleptis, pH, daya sebar, daya lekat, uji stabilitas, uji iritasi dan uji hedonik. Penelitian ini telah dilaksanakan 20 Mei - 09 Agustus 2022 di Laboratorium stikes ‘Aisyiyah Palembang. Hasil: Formula optimum terbaik diperoleh dengan komposisi beeswax 5% dan isoprofil miristat 1%. Formula optimum memiliki daya sebar 2,76 cm dan daya lekat 19,86 detik. Saran: Untuk penelitian berikutnya perhatikan suhu pada saat pengentalan ekstrak sehingga dapat menghasilkan sediaan blush on cream yang lebih baik.
Gambaran Dan Rasionalitas Penggunaan Obat Pada Terapi Penyalahgunaan Narkotika, Psikotropika, Dan Zat Adiktif Di Rumah Sakit Ernaldi Bahar Palembang Tahun 2020
Authors: Firdiawan Arie , Sari Evita , Rusli Doddy , Nurleni Novi
Published: October 2023

Penelitian mengenai gambaran dan rasionalitas penggunaan obat pada terapi penyalahgunaan narkotika, psikotropika, dan zat adiktif dirumah sakit ernaldi bahar Palembang. Penelitian ini bertujuan untuk mengetahui gambaran dan rasionalitas penggunaan obat pada terapi pasien penyalahgunaan narkotika, psikotropika dan zat adiktif dirumah sakit ernaldi bahar Palembang. Penelitian ini merupakan penelitian deskriptif dan data diambil secara retrospektif yang berasal dari data rekam medik pasien. Hasil penelitian ini menunjukkan bahwa terdapat 67 pasien yang memenuhi kriteria inklusi, penyalahgunan napza dengan jumlah tertinggi adalah amphetamine dan metamphetamine sebanyak 43 pasien (64%). Dan rasionalitas seluruh penggunaan obat yang digunakan pasien dirumah sakit ernaldi bahar Palembang berdasarkan tepat indikasi sebesar 85%, ketepatan pemilihan obat sebesar 85%, dan ketepatan dosis sebesar 59,7%.
PERBANDINGAN KANDUNGAN FITOKIMIA FRAKSI ETIL ASETAT DAUN KEMANGI (Ocimum basilicum Folium) DENGAN PERBEDAAN KETINGGIAN GEOGRAFIS TUMBUH
Authors: Hadi Ismanurrahman , Nurfazera Asya , Rohmatika Nirma
Published: October 2023

Daun kemangi (Ocimum basilicum folium) merupakan salah satu tumbuhan yang biasa digunakan sebagai obat tradisional adalah daun kemangi. Kemangi dapat tumbuh liar ataupun dibudidayakan. Perbedaan letak geografis tumbuh memberikan pengaruh pada senyawa fitokimia yang dihasilkan tumbuhan. Penelitian ini bertujuan untuk membandingkan senyawa fitokimia daun kemangi yang tumbuh pada perbedaan letak geografis. Daun kemangi didapatkan dari dataran rendah Cirebon dan dataran tinggi kabupaten Kuningan. Sampel yang digunakan yaitu fraksi etil asetat daun kemangi.Identifikasi senyawa fitokimia dilakukan untuk mengidentifikasi senyawa flavonoid, saponin dan terpenoid. Hasil uji menunjukkan fraksi daun kemangi dari datarn rendah dan dataran tinggi mengandung ketiga senyawa tersebut. Menariknya, pada identifikasi flavonoid dan terpenoid, dataran rendah memiliki flavonoid lebih banyak serta terpenoid yang lebih sedikit dari sampel dari dataran tinggi. Berdasarkan hal tersebut, dapat disimpulkan bahwa perbedaan geografis tumbuh menyebabkan adanya perbedaan kandungan senyawa fitokimia pada fraksi etil asetat daun kemangi
FORMULASI SEDIAAN KRIM ASAM KOJAT DENGAN VARIASI ISOPROPIL MIRISTAT SEBAGAI ENHANCER DAN EVALUASI STABILITAS FISIKA WAKTU SEBENARNYA
Authors: Nurleni Novi , Erviana Nur , Firdiawan Arie , Sari Ema Ratna
Published: October 2023

Asam kojat merupakan salah satu senyawa yang dapat menghambat aktivitas enzim tirosinase asam kojat juga sifatnya hidrofilik menjadikannya sulit untuk berpenetrasi ke dalam kulit sehingga membutuhkan suatu zat enhencer. Penelitian ini bertujuan untuk mengetahui apakah asam kojat dapat diformulasikan menjadi sediaan krim dan pengaruh penggunaan isopropil miristat sebagai enhancer. Krim dibuat dalam 3 formula yang memiliki variasi konsentrasi isopropil miristat 8%, 9%, dan 10%. Pengujian stabilitas fisika waktu sebenarnya yang diamati adalah perubahan organoleptis, homogentias, pH, dan viskositas yang diamati pada hari ke 0, 7, 14, 21 dan 28. Hari hasil analisa menunjukan formulasi krim asam kojat 9% merupakan formula terbaik dan stabil dibandingkan dengan formulasi lainnya.
Identifikasi Senyawa Metabolit Sekunder Ekstrak Etanolik Kulit Umbi bit (Beta vulgaris L.)
Authors: Putra Teguh Adiyas , Safitri Karin Angeline , Bisam Zahra Azizah Nursetya , Shinta Tiara Aries
Published: October 2023

Penelitian dengan judul Identifikasi Senyawa Metabolit Sekunder Ekstrak Etanolik Kulit Umbi bit (Beta vulgaris L.) bertujuan untuk mengetahui senyawa yang terkandung dalam kulit umbi bit. Umbi bit merupakan merupakan bahan pangan yang memiliki aktivitas tinggi antioksidan. Dari proses preparasi sampel serbuk simplisia yang dihasilkan diektraksi dengan metode maserasi, dilanjutkan dengan skrining fitokimia flavonoid, tanin, saponin dan alkaloid. Identifikasi fitokimia dilakukan secara kualitatif menggunakan pereaksi warna dan uji pengendapan. Identifikasi senyawa metabolit sekunder pada ekstrak etanolik kulit umbi bit dihasilkan positif mengandung flavonoid, tanin, saponin dan alkaloid.
EVALUASI PENGGUNAAN ANTIHIPERTENSI TERHADAP KADAR NATRIUM PADA PASIEN STROKE DENGAN KEJADIAN STROKE BERULANG DI RSUD DUNGUS MADIUN
Authors: Ristiana Dwiningrum Krisna
Published: October 2023

Stroke adalah tanda klinis yang berkembang cepat akibat gangguan fungsi otak lokal atau global dengan gejala yang berlangsung selama 24 jam atau lebih, dapat menyebabkan kematian. Beberapa faktor risiko yang dapat menyebabkan stroke yaitu hipertensi, diabetes mellitus, penyakit jantung, hiperlipidemia. Tujuan Penelitian adalah mengetahui karakteristik pasien stroke, gambaran terapi antihipertensi terkait kadar natrium dan kejadian stroke berulang serta mengetahui hubungan penggunaan antihipertensi terhadap kadar natrium pada pasien stroke di RSUD Dungus Madiun. Penelitian ini merupakan penelitian studi kohort prospektif. Metode teknik purposive sampling dimana pemilihan sampel dilakukan atas pertimbangan inklusi dan eksklusi dan mendapatkan 15 pasien. Hasil Karakteristik Pasien stroke di RSUD Dungus adalah untuk jenis kelamin Laki-laki sebanyak 60% dan Perempuan 40%, dan berdasarkan usia yang terbanyak pada lansia akhir (56-65 tahun) 80% dan lansia awal (46-55 tahun) 20%. Gambaran terapi antihipertensi terhadap kadar natrium pada Golongan Calcium Channel Bloker (CCB) mendapatkan nilai persentase 100% normal dan untuk golongan Calcium Channel Bloker (CCB) + Angiotensin Reseptor Blockers (ARB) kadar natrium normal 78,67% dan tidak normal 21,43%, kemudian terapi hipertensi terhadap kejadian stroke berulang tidak terdapat Kejadian Stroke berulang dengan persentase total 100%. Hubungan penggunaan antihipertensi terhadap kadar natrium pada pasien stroke di RSUD Dungus Madiun nilai p = 0,8, dimana nilai tersebut >0,05 maka H1 ditolak, sehingga dapat dikatakan tidak terdapat hubungan antara penggunaan antihipertensi dengan kadar natrium.
A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer
Authors: Tian Qiaomu , Zhang Peng , Wang Yihan , Si Youhui , Yin Dengping , Weber Christopher R , Fishel Melissa L , Pollok Karen E , Qiu Bo , Xiao Fei , Chong Anita S
Published: October 2023

Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, the 5 -year survival rate stands at only 12%. Triptolides have potent anti-tumor activity against different types of cancers, including pancreatic cancer, however poor solubility and toxicity limit their translation into clinical use. We synthesized a novel pro-drug of triptolide, (E)–19-[(1’-benzoyloxy-1’-phenyl)-methylidene]-Triptolide (CK21), which was formulated into an emulsion for in vitro and in vivo testing in rats and mice, and used human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids. A time-course transcriptomic profiling of tumor organoids treated with CK21 in vitro was conducted to define its mechanism of action, as well as transcriptomic profiling at a single time point post-CK21 administration in vivo. Intravenous administration of emulsified CK21 resulted in the stable release of triptolide, and potent anti-proliferative effects on human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids in vitro, and with minimal toxicity in vivo. Time course transcriptomic profiling of tumor organoids treated with CK21 in vitro revealed <10 differentially expressed genes (DEGs) at 3 hr and ~8,000 DEGs at 12 hr. Overall inhibition of general RNA transcription was observed, and Ingenuity pathway analysis together with functional cellular assays confirmed inhibition of the NF-κB pathway, increased oxidative phosphorylation and mitochondrial dysfunction, leading ultimately to increased reactive oxygen species (ROS) production, reduced B-cell-lymphoma protein 2 (BCL2) expression, and mitochondrial-mediated tumor cell apoptosis. Thus, CK21 is a novel pro-drug of triptolide that exerts potent anti-proliferative effects on human pancreatic tumors by inhibiting the NF-κB pathway, leading ultimately to mitochondrial-mediated tumor cell apoptosis.
Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
Authors: Zoltowska Katarzyna Marta , Das Utpal , Lismont Sam , Enzlein Thomas , Maesako Masato , Houser Mei CQ , Franco Maria Luisa , Özcan Burcu , Gomes Moreira Diana , Karachentsev Dmitry , Becker Ann , Hopf Carsten , Vilar Marçal , Berezovska Oksana , Mobley William , Chávez-Gutiérrez Lucía
Published: October 2023

Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimer’s disease (AD). However, molecular cascades underlying their toxicity are poorly defined. Here, we explored a novel hypothesis for Aβ42 toxicity that arises from its proven affinity for γ-secretases. We hypothesized that the reported increases in Aβ42, particularly in the endolysosomal compartment, promote the establishment of a product feedback inhibitory mechanism on γ-secretases, and thereby impair downstream signaling events. We conducted kinetic analyses of γ-secretase activity in cell-free systems in the presence of Aβ, as well as cell-based and ex vivo assays in neuronal cell lines, neurons, and brain synaptosomes to assess the impact of Aβ on γ-secretases. We show that human Aβ42 peptides, but neither murine Aβ42 nor human Aβ17–42 (p3), inhibit γ-secretases and trigger accumulation of unprocessed substrates in neurons, including C-terminal fragments (CTFs) of APP, p75, and pan-cadherin. Moreover, Aβ42 treatment dysregulated cellular homeostasis, as shown by the induction of p75-dependent neuronal death in two distinct cellular systems. Our findings raise the possibility that pathological elevations in Aβ42 contribute to cellular toxicity via the γ-secretase inhibition, and provide a novel conceptual framework to address Aβ toxicity in the context of γ-secretase-dependent homeostatic signaling.
Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment
Authors: Urbancokova Alexandra , Hornofova Terezie , Novak Josef , Salajkova Sarka Andrs , Stemberkova Hubackova Sona , Uvizl Alena , Buchtova Tereza , Mistrik Martin , McStay Brian , Hodny Zdenek , Bartek Jiri , Vasicova Pavla
Published: October 2023

PML, a multifunctional protein, is crucial for forming PML-nuclear bodies involved in stress responses. Under specific conditions, PML associates with nucleolar caps formed after RNA polymerase I (RNAPI) inhibition, leading to PML-nucleolar associations (PNAs). This study investigates PNAs-inducing stimuli by exposing cells to various genotoxic stresses. We found that the most potent inducers of PNAs introduced topological stress and inhibited RNAPI. Doxorubicin, the most effective compound, induced double-strand breaks (DSBs) in the rDNA locus. PNAs co-localized with damaged rDNA, segregating it from active nucleoli. Cleaving the rDNA locus with I-PpoI confirmed rDNA damage as a genuine stimulus for PNAs. Inhibition of ATM, ATR kinases, and RAD51 reduced I-PpoI-induced PNAs, highlighting the importance of ATM/ATR-dependent nucleolar cap formation and homologous recombination (HR) in their triggering. I-PpoI-induced PNAs co-localized with rDNA DSBs positive for RPA32-pS33 but deficient in RAD51, indicating resected DNA unable to complete HR repair. Our findings suggest that PNAs form in response to persistent rDNA damage within the nucleolar cap, highlighting the interplay between PML/PNAs and rDNA alterations due to topological stress, RNAPI inhibition, and rDNA DSBs destined for HR. Cells with persistent PNAs undergo senescence, suggesting PNAs help avoid rDNA instability, with implications for tumorigenesis and aging.
An English course practice evaluation system based on multi-source mobile information and IoT technology
Authors: Wang Zhenlong
Published: October 2023

With the increased use of online English courses, the quality of the course directly determines its efficacy. Recently, various industries have continuously employed Internet of Things (IoT) technology, which has considerable scene adaptability. To better supervise the specific content of English courses, we discuss how to apply multi-source mobile Internet of Things information technology to the practical evaluation system of English courses to boost the performance of English learning evaluation. Therefore, by analyzing the problems of existing English course evaluation and the characteristics of multi-source mobile Internet of Things information technology, this article designs an English course practical evaluation system based on multi-source data collection, processing, and analysis. The system can collect real-time student voices, behavior, and other data through mobile devices. Then, analyze the data using cloud computing and data mining technology and provide real-time learning progress and feedback. We can demonstrate that the accuracy of the evaluation system can reach 80.23%, which can effectively improve the efficiency of English learning evaluation, provide a new method for English teaching evaluation, and further improve and optimize the English education teaching content to meet the needs of the actual teaching environment.
A remaining useful life estimation method based on long short-term memory and federated learning for electric vehicles in smart cities
Authors: Chen Xuejiao , Chen Zhaonan , Zhang Mu , Wang Zixuan , Liu Minyao , Fu Mengyi , Wang Pan
Published: October 2023

In modern society, environmental sustainability is a top priority as one of the most promising entities in the new energy sector. Electric vehicles (EVs) are rapidly gaining popularity due to their promise of better performance and comfort. Above all, they can help address the problem of urban air pollution. Nonetheless, lithium batteries, one of the most essential and expensive components of EVs, have posed challenges, such as battery aging, personal safety, and recycling. Precisely estimating the remaining useful life (RUL) of lithium battery packs can effectively assist in enhancing the personal safety of EVs and facilitating secondary trading and recycling in other industries without compromising safety and reliability. However, the RUL estimation of batteries involves many variables, and the operating conditions of EV batteries are highly dynamic as they change with the environment and the driving style of the users. Many existing methods exist to estimate the RUL based on batteries’ state of health (SOH), but only some are suitable for real-world data. There are several difficulties as follows. Firstly, obtaining data about battery usage in the real world takes work. Secondly, most of these estimation models must be more representative and generalized because they are trained on separate data for each battery. Lastly, collecting data for centralized training may lead to a breach of user privacy. In this article, we propose an RUL estimation method utilizing a deep learning (DL) approach based on long short-term memory (LSTM) and federated learning (FL) to predict the RUL of lithium batteries. We refrain from incorporating unmeasurable variables as inputs and instead develop an estimation model leveraging LSTM, capitalizing on its ability to predict time series data. In addition, we apply the FL framework to train the model to protect users’ battery data privacy. We verified the results of the model on experimental data. Meanwhile, we analyzed the model on actual data by comparing its mean absolute and relative errors. The comparison of the training and prediction results of the three sets of experiments shows that the federated training method achieves higher accuracy in predicting battery RUL compared to the centralized training method and another DL method, with solid training stability.
Os desafios da sucessão em empresas familiares: perspectivas das mulheres herdeiras
Authors: Tibola Jeniffer Endriel , Ruffatto Juliane , Spada Rafael
Published: October 2023

Esse estudo aborda o processo sucessório em empresas familiares, com foco na presença de mulheres como sucessoras ou possíveis sucessoras. Discute esse fato pela ótica de mulheres, trazendo uma visão feminina sobre o assunto. A pesquisa foi desenvolvida por meio de entrevista semiestruturada envolvendo 8 mulheres que estão passando ou já tenham passado pelo processo de sucessão, com objetivo de identificar quais são as dificuldades encontradas e enfrentadas por mulheres, no processo sucessório de empresas familiares. Trouxe como resultados traços machistas ainda presentes nas, fazendo com que a participação de mulheres seja dificultada pelo ambiente ainda predominante pelo masculino. Mesmo atuando em empresas familiares mulheres enfrentam diversas barreiras, suas carreiras são limitadas e sofrem exclusão em diversos processos, inclusive o sucessório. Acredita-se que esse trabalho possa contribuir para um melhor entendimento da participação e da importância da mulher em empresas familiares e traga mudanças positivas para dentro das organizações.
Do código à confiabilidade: Lógica Paraconsistente impulsionada por Python para a detecção de alarmes na rede de energia
Authors: De Oliveira Joseffe Barroso , Gino João Vitor Santa Rosa , De Lima Carlos José , Da Silva Filho João Inácio
Published: October 2023

Este estudo propõe um modelo que aborda a normalização, processamento e avaliação de dados relacionados a medições elétricas e seus alarmes correspondentes usando a Lógica Paraconsistente Anotada de Dois Valores (LPA2v). Esta abordagem lógica não convencional é capaz de lidar com informações contraditórias. Os dados das medições elétricas e dos alarmes são coletados de subestações de transmissão e distribuição de energia elétrica, e posteriormente são transferidos para um novo banco de dados e ajustados para serem compatíveis com a LPA. A Lógica Paraconsistente é aplicada por meio do Algoritmo Para-Analisador, com o objetivo de extrair informações cruciais, como o tipo de situação representada pelo Estado Lógico Resultante. Isso possibilita a comparação entre os alarmes disparados e os estados lógicos resultantes obtidos durante a análise. Como resultado desta pesquisa, foi desenvolvido um sistema de software em linguagem Python que é capaz de realizar análises paraconsistentes e identificar alarmes em bancos de dados de subestações de transmissão e distribuição de energia elétrica.
Opções reais: uma aplicação prática
Authors: Da Silva Antônio Carlos Magalhães , Dos Santos Marcus Vinícius , Oliveira Giane Costa , Dias Eric Ivantes , Peres Marcos Antonio Simões
Published: October 2023

A metodologia mais comum utilizada para avaliar projetos é a do Fluxo de Caixa Descontado, porém apesar de ser intuitiva e de fácil aplicação, ao considerar que os fluxos de caixa do projeto serão constantes, não incorpora as incertezas futuras e flexibilidades gerenciais que o projeto possa ter. Alternativamente, a Teoria das Opções Reais surge como uma metodologia complementar ao do Fluxo de Caixa Descontado, ao agregar as incertezas e flexibilidades ao projeto. Para ilustrar as vantagens da Teoria das Opções Reais, o presente trabalho a utilizou para avaliar financeiramente um projeto de mineração de carvão na África, onde há opção de expansão e de abandono do projeto ao final do 5º ano de operação. A existência das opções fez com que o valor do projeto aumentasse em cerca de 30%. Assim, comprovamos através da modelagem binomial que as opções agregam valor ao projeto, principalmente quando existem simultaneamente.
Aplicação de inteligência artificial através de algoritmos de aprendizagem de máquina para redução do número de OS em campo, baseado em falhas encontradas na linha de montagem de refrigeradores em uma indústria multinacional de bens de consumo
Authors: De Oliveira Joseffe Barroso , Gino João Vitor Santa Rosa , Da Silva Filho João Inácio , De Lima Carlos José
Published: October 2023

Este trabalho consiste na aplicação de inteligência artificial através de algoritmos de aprendizagem de máquina para redução de ordens de serviço de uma indústria multinacional de bens de consumo. Os dados utilizados neste trabalho são provenientes das falhas da linha de montagem de refrigeradores e ordens de serviço geradas para refrigeradores pós-venda em um intervalo de 6 meses após serem fabricados. Os dados das falhas de montagem de refrigeradores são obtidos através da linha de montagem industrial, que consecutivamente são gravados em bases de dados específicas. Após isso, os dados são migrados para uma nova base de dados e normalizados para a aplicação da IA. Assim como os dados de ordens de serviço que são gerados, gravados em bases de dados específicas, normalizados e migrados para uma nova base de dados, prontos para serem manipulados com IA. A separação, normalização e organização dos dados é realizada através da linguagem SQL e uma base de dados SQL Server. Já, a Inteligência Artificial é utilizada através da aplicação de algoritmos de aprendizagem de máquina como Random Forest, Light GBM e Linear Regression, por meio da linguagem de programação Python e técnicas como Grid Search e Cross Validação. Sendo assim, o objetivo principal da combinação dessas tecnologias é apresentar as principais falhas que contribuem para geração de ordens de serviço e a predição da quantidade de OS que poderão ser geradas, baseado nas falhas que aconteceram na linha de montagem industrial de refrigeradores.
Use of Fertilizers and Pesticides in Vegetable Growing and their Impact on the Ecosystem in the Comoé River Watershed, Burkina Faso
Authors: Gomgnimbou A. P. K.  , Kara N. M.  , Hamadé Sigue , Sanon A.  , Pare S.
Published: October 2023

Background an Aims: The use of pesticides and chemical fertilizers has been practised for centuries to control pests and increase agricultural productivity. However, mismanagement of these products can entail health and environmental risks. This study was initiated to assess the impact of these practices on the CRW ecosystem. The aim of this study is to characterize pesticide and fertilizer use practices in vegetable growing in the Comoé river watershed (CRW).

Study Design: This study was carried out on a sample of market gardeners chosen randomly. Data collection was done transversally.

Place and Duration of Study: This study was conducted in Western Burkina Faso during the dry period of 2020. It concerned market gardeners who carry out their activity in the Comoé Basin.

Methodology: To this end, a survey was carried out among a representative sample of 204 vegetable growers. The survey sheet was used to collect information on the level of education, speculations, origins of fertilizers and pesticides, and the management of fertilizers and pesticides in the CRW.

Results: The study revealed that local vegetable growers use both organic and chemical fertilizers. They obtain their supplies from the local market. In fact, 91% of the vegetable growers interviewed use both types of fertilizer. Growers are unaware of the validity period of the products they use. In addition, 48% of growers say they do not know or do not pay attention to the expiry date of products. Furthermore, 82% of growers do not master fertilizer application doses. Current pesticide and fertilizer use practices are risky, and the dangers incurred are pollution, particularly water pollution, and its consequences on human and environmental health (soil, vegetation, etc.). It would therefore be wise to encourage and promote biological pest control in order to preserve human and animal health and the environment.
The Analysis of Financial Report Effectiveness through Berlo Communication Model: A Case Study of PT Megah Sembada Industry, Indonesia
Authors: Setiawan Selfie , Fardinal  , Hidayah Nurul
Published: October 2023

Aims: Effective communication is crucial in the delivery of the company's financial reports, to ensure that the reports produced can meet their objectives as receivers of financial information. This study aimed to empirically investigate the determinants that affect the effectiveness of corporate financial reporting.

Study Design:  The research method employed in this study is descriptive quantitative research.

Place and Duration of Study: The study was conducted at Perseroan Terbatas Megah Sembada Industri (PT. MSI), a prominent nonwoven manufacturer specializing in disposable products and healthcare items in Indonesia.

Methodology: Data collection techniques was collected by observation, interviews, documentation, and distributing questionnaires.

Results: The results showed that the application of Berlo's SMCR (Source, Message, Channel, and Receiver) model in accounting information communication at PT MSI provides positive results in creating an effective work environment and producing quality financial reports.

Conclusion: This study confirmed that PT. MSI is able to report on time and accurately every month according to the actual data. The implication of this finding can be a foundation for other companies in improving their accounting information communication process to achieve better goals.
A Systematic Review on Detection of Chlorpyrifos Herbicide Residues in Water Resources, Soil, and Vegetable Matrices: Possible Amendments
Authors: Njewa Joel Brian , Majamanda James Jamzy , Biswick Timothy Tiwonge , Suman Jimmy Jay , Mwase Emmanuel , Banda Gladys Chimwemwe , Lagat Silas Cheruiyot
Published: October 2023

The presence of widely used Chlorpyrifos pesticide residues in the environment increases concerns owing to its associated adverse effects on human health and the ecosystem. The present study reports the comprehensive analysis of published papers concerning the detection of Chlorpyrifos herbicide residues in water resources, vegetables and soil matrices. The results showed that Chlorpyrifos residues were frequently found in water resources, plants and soil matrices in excess, beyond permissible levels. The results collected, point to possible hazards to the aquatic ecosystem and human beings in general due to pollution of drinking water, exposure to pesticide residues through edible crops and long-term effects on soil quality and crop growth. This present study emphasizes on the urgent need for remediation alternative actions, such as ceasing or restricting the use of Chlorpyrifos, improving water treatment techniques and implementing best agricultural management practices.
Statistical Analysis of the Beta Transmuted Standardized Half Logistic Distribution: Properties, Estimation, and Real-Data Application
Authors: Awodutire P. O. , Nduka E. C. , Olosunde A.
Published: October 2023

In this paper, a new distribution called the Beta Transmuted Half Logistic Distribution is derived and studied using the Beta Transmuted-G distribution. The distribution generalizes the half logistic distribution for more flexibility. Then expressions for the moments, moment generating function, order statistic, survival function, and the hazard function were studied. Estimation of parameters of the model was done using the maximum likelihood estimation approach. Simulation studies were conducted to assess the performance of the estimates of the parameter. Furthermore, the distribution is applied to a real-life dataset, demonstrating its superior performance in terms of producing a better fit compared to its submodels. This research contributes to the field of probability distributions and provides a valuable tool for modeling and analyzing various types of data.
Effect of Polyethylene Glycol (PEG) on Germination and Seedling Parameters of Maize Varieties
Authors: Sajjad Zain ul , Fatima Zohaa , Awais Muhammad , Waheed Abdul , Ali Arham , Hashmi Qasim Ali , Abbas Mobeen , Sufyan Abu
Published: October 2023

In an experimental framework employing a Factorial Randomized Complete Block Design (FRBCD), a study was conducted in July 2022 at the Crop Science Institute, NARC, Islamabad. The objective was to assess the impact of different Polyethylene Glycol (PEG) concentrations on two maize cultivars Sargodha 202 and OPV-3 under drought stress conditions. With triplicate replications, each experimental unit consisted of a pot filled with 4.5 kg of dry sand, where 10 seeds were planted. The 45-day study incorporated four treatment groups: T0 (Control), T1 (10% PEG), T2 (20% PEG), and T3 (30% PEG).

Data analysis revealed that increasing PEG concentrations led to a decline in key parameters such as germination rate, root elongation, and shoot development, while concurrently escalating seedling mortality in both cultivars. Statistical evaluations, carried out through the Least Significant Difference (LSD) method at a 5% significance level, highlighted notable differences between the treatment outcomes. Sargodha 202 exhibited superior performance relative to OPV-3, recording a germination rate of 91.66% as opposed to OPV-3's 83.33%. Furthermore, Sargodha 202 demonstrated enhanced root (13.08 cm) and shoot (50.08 cm) lengths in comparison to OPV-3, which showed 10.58 cm for root and 45.83 cm for shoot length. Sargodha 202 also displayed elevated levels of both root and shoot moisture content and a higher crop growth rate compared to OPV-3. Collectively, these results underscore the greater resilience and adaptability of Sargodha 202 under PEG-induced drought conditions.
Evaluation of In-vitro Anti-inflammatory Activity of Sri Lankan Medicinal Pill of Aloe vera, Centella asiatica, and Strychnos potatorum Exacts Using Egg Albumin Denaturation Assay
Authors: Pushpika G. D. S. , Maddumage R. S. , Perera H. E. H. , Fernando R. S. P. , Silva A. R. N.
Published: October 2023

Aims: The study aims to evaluate the albumin heat denaturalization inhibition activity of a Sri Lankan Traditional Medicine pill (STMP) as an indirect measure of anti-inflammation.

Methodology: The extracts of Aloe vera, Centella asiatica (Asiatic pennywort), and Strychnos potatorum (Cleaning nut) are the ingredients of the pill. Concentration gradients from 1000 µg/ml to 0.02 µg/ml were prepared using egg albumin and phosphate buffer saline. The pill was incubated in controlled experimental settings at various concentrations, and the absorbance was measured to quantify the level of albumin denaturation.  One NSAID (Ibuprofen) and one steroid (Prednisolone) were used as the reference drugs. The percentage inhibition of protein denaturation at each concentration was calculated by using the formula of (Vt / Vc - 1) x 100% where Vt = absorbance of the test sample and Vc = absorbance of control.

Results: The maximum inhibition rate of egg albumin denaturation (46.7%) was seen in the 200 µg/ml concentration, while Prednisolone and Ibuprofen had 2.5% and 24.6% inhibition rates in the same concentration, respectively.  Less than 35% inhibition rate of egg albumin denaturation showed in all other concentrations lower than 200 µg/ml (0.1 µg/ml – 100 µg/ml) of this STMP. The inhibition rates of these concentrations did not differ noticeably from those of the reference medications.  In addition, the STMP had a 28.3% inhibited rate of egg albumin denaturation in 1000 µg/ml concentration while Prednisolone and Ibuprofen showed low inhibition rates compared to the STMP (3.4% and 13.8% respectively) in this concentration.

Conclusion: This study discovered that 200 µg/ml of the tested Sri Lankan Traditional Medicine pill had the strongest anti-inflammatory efficacy against protein denaturation.  Furthermore, the effect against albumin denaturation in high-concentration Sri Lankan STMP (200 µg/ml and 1000 µg/ml) surpassed that of the reference drugs, signifying a more pronounced impact.
Effects of Different Temperature Treatments on Seed Germination and Seedling Growth of Rorippa sylvestris
Authors: Yan Hai ling , Shi Gui Li , Shi Wen Peng , Jin Mei Ting , Sun Yi Nuo , Qu Bo , Shao Mei Ni
Published: October 2023

Temperature is one of the important conditions for plant growth, and an important factor affecting the establishment and spread of invasive plants. In this study, the northern perennial invasive plant (Rorippa sylvestris) was taken as an example. By comparing the seed germination rate, germination potential, germination index and vigor index, the total number of leaves, root length, root length, vigor index, leaves of seedings, seedling biomass and root- shoot ratio under different temperature treatments (15, 20, 25, 30, 35, 40℃), the subordinate function was used to compare the temperature tolerance of R. sylvestris in seed germination. sylvestris in seed germination and seedling growth. To study the response and tolerance of seed germination and seedling growth of invasive R. sylvestris to different temperatures, the subordinate function was used to compare the temperature tolerance of R. sylvestris in seed germination and seedling growth. The results showed that high temperature promoted seed germination of R. sylvestris and limited radicle growth, and it had the most tolerance at different temperatures. The results showed that high temperature promoted seed germination of R. sylvestris and limited radicle growth, and it had the strongest tolerance at 35℃. Lower temperature was more beneficial to material accumulation of seedlings, and the tolerance of R. sylvestris was more favorable. The results provide theoretical basis for revealing the diffusion and invasion mechanism of R. sylvestris.
Influence of Pseudomonas and Biofertisol as a Foliar Spray on Soil Properties under STCR Approach
Authors: Tekam Yagini , Sahu Rakesh , Thakur Risikesh , Padwar Garima , Singh Deepak
Published: October 2023

A field experiment was conducted during the rabi season in the Experimental field, Department of Soil Science, JNKVV, Jabalpur (M.P.) under RBD design with four replications comprising five treatments of two types of biofertilizers: Pseudomonas and Biofertisol and scheduled combinations of inorganic fertilizers based on STCR (Soil Test Crop Response) for achieving targeted yield by using variety of vegetable pea, PSM-3. The best response was recorded from the application of treatment T5 (TY120 q(87:147:74) +5tFYM) for increasing the content of soil available nutrients (N, P and K) by 7.89, 29.95 and 8.25%, respectively over that from control. Effect due to T4 was significantly prominent on the proliferation of microorganisms viz., Rhizobium sp., Pseudomonas sp., and Lactobacillus sp. better by 6.79 log cfu (61.38 x 105 cfu g-1 soil), 6.44 log cfu (27.67 x 105 cfu g-1 soil) and 4.42 log cfu (26.18 x 103 cfu g-1 soil), respectively over control. The same treatment T4 induced the enzyme activity of dehydrogenase by 86.99% as compared to that of the control (5.23 µg TPF hr-1 g-1). Yields of the crop were best harvested due to T4 by 81.91% over that of control 56.93 kg ha-1. The vegetable pea (Pisum sativum L.), a cool-season crop and an important pulse crop in India. One of the impediments to supporting vegetable pea production and productivity is low soil fertility. Anthropogenic causes such as heavy use of fertilizer exacerbated the problem. A combination of fertilizers, biofertilizers and FYM are the solution to the problem since it makes use of available organic and inorganic nutrients and microbes to create an environmentally sound and economically sustainable farming system.
Evaluation of Broad Bean (Vicia faba L) Genotypes for Genetic Variability, Heritability and Genetic Advance
Authors: Kumar Sunil , Dwivedi Deepa H. , Yadav Putan , Kumar Virendra , Dayal Rameshwar
Published: October 2023

The study investigated the phenotypic and genotypic coefficient of variation (PCV and GCV) and heritability estimates for various agronomic and nutritional traits in Broad bean (Vicia faba). The analysis aimed to identify traits with optimum variability and heritability, as well as to explore the potential presence of additive genetic variance in specific characteristics.The 18 genotypes were grown in randomized block design with the 3 replication during Rabi season in the year 2021-22 at the Research Farm- 1, Department of Horticulture, Babasaheb Bhimrao Ambedkar University, Vidya-Vihar, Raebareli Road, Lucknow-226025 (U.P.). The results showed that umber of seed per plant, number of pod per plant and seed yield per plant exhibited high estimates of both PCV and GCV, indicating the presence of adequate variability for these particular characters within the population. Additionally, the heritability for the characters of 100 seed yield, number of seed per plant, titratable acidity (g/l), total soluble solids (TSS) and genetic advance for the number of seed per plant, number of pod per plant, seed yield per plant, 100 seed weight were found to be significant indicating that these characters were predominantly governed by additive gene action. The findings of this study hold significant implications for future breeding programs and genetic improvement strategies. The high heritability and genetic advance for the above-mentioned characters suggest that these characteristics can be effectively manipulated through selective breeding to develop improved and high-yielding plant varieties.
Impact of Herbicides on Soil Fertility and Nutrient Uptake by Transplanted Rice (Oryza sativa L.) in Eastern U.P, India
Authors: Jaysawal Peeyush Kumar , Verma S. K. , Pratap Vijay , Yadav Deepak Kumar , Tirkey Niketa , Singh Sachin
Published: October 2023

A field experiment was carried out at Agricultural Research Farm, Institute of Agricultural Sciences, Varanasi during kharif 2017 and 2018 to evaluate the nitrogen intake by transplanted rice (Oryza sativa L.) and the available nutrient status of soil under ten weed control treatments. The treatment bispyribac-Na 9.1% (24.57 g/ha) + metsulfuron-methyl 1.2% (3.24 g/ha) + chlorimuron ethyl 1.2% (3.24 g/ha) recorded higher Organic carbon (0.47%), pH (7.38), EC(0.18 dS m-1), available N193.48 kg/ha, P22.46 kg/ha, and K 221.56 kg/ha in soil, higher nutrient (N, P and K)  content in grain 1.14, 0.33, 0.38%,  and straw  0.74, 0.12, 1.74% and protein content 6.81 & 4.42% in grain and straw, respectively. improved N, P, K uptake in grain 58.57, 17.06, 19.23 kg/ha and straw 71.00, 11.36, 166 kg/ha, respectively over weedy check (grain 46.09, 13.35, 15.10 kg/ha and straw 58.58, 9.38 and 137.65 N, P and K respectively). This treatment exhibited positive performance of soil fertility and N, P and K uptake by transplanted rice.
Response of Inorganic Fertilizers, Organic Manure and Biofertilizer on the Physical Parameters of the Soil under the Cultivation of Chickpea (Cicer arietinum L.) CV. Arun
Authors: Kumar Anil , David Arun Alfred , Thomas Tarence , Bharose Ram , Swaroop Narendra , Lall Alok M. , Reddy Iska Srinath , Serawat Rohan , Toppo Neha
Published: October 2023

Application of inorganic fertilizer, biofertilizer and organic manure to the soil can have various effects on the physical parameters of soil, such as soil structure, porosity, water holding capacity, bulk density. The designed lay out 48 total soil samples were taken from different depths 0-15 cm and 15-30 cm. The optimal combination of these inputs depends on the type of soil, crop and climate. Generally, the application of organic manure can improve the soil structure and porosity, while the addition of biofertilizer can enhance the soil fertility and microbial activity. The use of inorganic fertilizer can provide essential nutrients for plant growth, but it should be applied in appropriate amounts and forms to avoid negative impacts on the soil quality.  The conjunctive use of N P K and different vermicompost and rhizobium the treatment T16- [RDF @ 100 % + VC @ 100 % + Rhizobium @ 100 %] gave best results physical properties of soil.
Burn Out and Psychological Distress among Care Givers of Dementia Patients Attending the Out Patient Geriatric Clinics of Two Nigerian Tertiary Health Institutions
Authors: Okwaraji Friday E. , Onyebueke Godwin C. , Nwakaego Okwor Esther
Published: October 2023

Aim: This study investigated burnout and psychological distress among 460 caregivers of dementia patients attending the outpatient geriatric clinics of two Nigerian tertiary health institutions. 
Study Design: The study used the descriptive cross sectional study design.
Place and Duration of the Study: The study was conducted at the outpatient geriatric clinics of two tertiary health institutions in Enugu, South East Nigeria between the months of July and August 2023.
Methodology: A total of 460 care givers of dementia patients, aged 18- 65 years, attending the outpatient geriatric clinics of two tertiary health institutions in Enugu, who consented to participate in the study, were assessed for burnout and psychological distress using the Maslach Burnout Inventory (MBI), and the General Health Questionnaire (GHQ-12).
Results: Result showed that 23.9% had emotional exhaustion, 14.6% had depersonalization and 18.5% had reduced personal accomplishment, while psychological distress was present in 39.6% of the respondents. Significant relationships were noticed between age and psychological distress, \(\chi\)2=57.36; p= 0.03; marital status and burnout \(\chi\)2=10.95; P= 0.01 as well as education and psychological distress \(\chi\)2=10.95; p= 0.05.
Conclusion: High levels of burnout and psychological distress were present among the caregivers who participated in the study, in view of this there is need for government to ensure proper institutional care for dementia patients and provide some incentives for those who care for them. Policy formulation should also aim at establishing community caregiving centers were dementia patients can receive adequate attention from government agencies.
Overcoming ROS Resistance of Photodynamic Therapy with Self‐Assembled Nano‐Prodrugs for Efficient Triple‐Negative Breast Cancer
Authors: Li Bowen , Tian Jianwu , Xie Xin , Zhang Fu , Wu Chongzhi , Shan Yi , Qi Guobin , Song Wentao , Ping Yuan , Liu Bin
Published: October 2023

Triple‐negative breast cancer (TNBC) is endowed with a highly aggressive nature that results in distant metastases and high recurrence rates, yet limited success is realized in traditional chemotherapy. Activatable photosensitizers (PSs) may provide an effective and non‐invasive strategy to induce TNBC cell death in a precise way by offering stimuli‐responsive reactive oxygen species (ROS). However, the toxicity of ROS is often mitigated and even devitalized by the instinctive behavior of ROS resistance in TNBC cells. To address this issue, herein a small molecular self‐assembly nano‐prodrug is presented to co‐deliver an activatable PS and ROS resistance inhibitor. In TNBC cells, the overexpressed glutathione can disassemble the nano‐prodrug, thereby releasing ROS resistance inhibitor and activating the PS for photodynamic therapy and fluorescence imaging. A hybrid membrane coating‐assisted nanoparticle formation strategy is further demonstrated for efficient inhibition of tumor growth and distant metastases on both subcutaneous and orthotopic TNBC mice models.