bluuebunny/crossref_metadata_2025 huggingface dataset:
A COMPLETE LBBB REVEALING NON SPECIFIC VENOUS METASTASIS INTO THE RIGHT ATRIUM : A CASE REPORT AND REVIEW OF LITERATURE
Authors: Belidi Abir EL , Hind Regragui , Sabrine Derquaoui , Hafsa Chahdi , Najat Mouine
Published: June 2022

The primary heart tumors are rare, whereas metastatic heart tumors occur more frequently. We presente a case of an asymptomatic 71-year-old man diagnosed with isolated right atrium metastasis of a poorly differentiated hepatic carcinoma by direct inferior vena cava invasion the patient opted out of any intervention and was discharged under VKA. The prevalence of secondary cardiac tumors has been reported as 10 to 12% in autopsy studies. Clinically, cardiac metastasis usually remains asymptomatic and detected incidentally. The techniques mainly used in assessment of cardiac lesions include transthoracic and transoesophageal echocardiogram, CT scans and MRI. Treatment of metastatic cardiac tumor is usually palliative, because the overall prognosis is poor. A multidisciplinary approach involving cardiologists, oncologists, and cardiothoracic surgeons is crucial for deciding the best therapeutic regimen for such patients.
COVID -19 CHEZ LES PATIENTS DIABETIQUES : PRISE EN CHARGE EN UNITE DE SOINS INTENSIFS
Authors:   Service dEndocrinologie, Diabetologie, Maladies Metaboliques et Nutrition - CHU Mohamed VI de Marrakech-Maroc., Maryame Benlafqih , Sara Chtioui ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques et Nutrition - CHU Mohamed VI de Marrakech-Maroc., Sanaa Rafi ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques et Nutrition - CHU Mohamed VI de Marrakech-Maroc., Mghari Ghizlane El ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques et Nutrition - CHU Mohamed VI de Marrakech-Maroc., Ansari Nawal EL ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques et Nutrition - CHU Mohamed VI de Marrakech-Maroc.
Published: June 2022

Context :The presence of diabetes has been identified as a factor associated with severe forms and increased mortality during SARS-COV 2 infection. On the other hand, it has been suggested that infection with COVID 19 would be susceptible to induce Novo diabetes. Managing diabetes during COVID 19 infection is an important part of managing this infection. Goal :The aim of this work is to describe the characteristics of diabetic patients infected with COVID -19 and to share our experience in their management. Materials and methods: retrospective study of 104 patients admitted to the intensive care unit at Ibn Tofails company hospital. Results: The mean age of our patients was 64.47 years. Diabetes was discovered during infection in 22% of patients, while 78% of patients were known to have diabetes. Ketosis decompensation was demonstrated in 16.3% of patients. On admission, 32% were on oral antidiabetics and 38% patients were on insulin. Thoracic CT showed more than 50% of the pulmonary parenchyma in 43% of patients. 12.5% â€‹â€‹of our patients were hemodynamically and respiratory unstable and were transferred to medical intensive care. Conclusion: our study had shown that diabetes was associated with severe forms of COVID 19 with significant inflammatory syndrome and extensive lung damage.
ENHANCED EFFECTS OF CHOLECALCIFEROL PLUS PIOGLITAZONE ON LIPOLYSIS BY UP-REGULATION OF PPAR-ALPHA MRNA IN MATURE 3T3-L1 ADIPOCYTES
Authors:   Centro de Investigaciones Biomedicas, Universidad Veracruzana, Av. Luis Castelazo Ayala S/N, Col. Industrial Animas, Xalapa, Veracruz, Mexico. CP. 91190., Janeth Hernandez-Jimenez , Omar Arroyo-Xochihua ,   Biomedicine in public health Laboratory, Public Health Institute, Universidad Veracruzana. Av. Luis Castelazo Ayala S/N, Col. Industrial Animas, Xalapa, Veracruz CP. 91190, Mexico., Carlos Mendoza-Soto ,   Biomedicine in public health Laboratory, Public Health Institute, Universidad Veracruzana. Av. Luis Castelazo Ayala S/N, Col. Industrial Animas, Xalapa, Veracruz CP. 91190, Mexico., Rocio Coutino-Rodriguez ,   Biomedicine in public health Laboratory, Public Health Institute, Universidad Veracruzana. Av. Luis Castelazo Ayala S/N, Col. Industrial Animas, Xalapa, Veracruz CP. 91190, Mexico., Omar Arroyo-Helguera ,   Biomedicine in public health Laboratory, Public Health Institute, Universidad Veracruzana. Av. Luis Castelazo Ayala S/N, Col. Industrial Animas, Xalapa, Veracruz CP. 91190, Mexico.
Published: June 2022

Introduction:Vitamin D deficiency has been associated with obesity, diabetes mellitus type 2, and hypertension diseases. The active vitamin D binds to nuclear vitamin D receptor (VDR) and regulating lipids and carbohydrates metabolism genes however, prophylaxis is ruled out because induce hypercalcemia and hyperphosphatemia. VDR and the peroxisome proliferator-activated receptor gamma (PPARÃŽÂ³) cross-talk regulates lipid and glucose metabolism genes. Methods: In this study was analyze the effect of cholecalciferol (CCF) as vitamin D plus pioglitazone (PIO) on mature 3T3-L1 adipocytes on proliferation, fat accumulation by colorimetric methods and the mRNA genes involved in lipid signaling by RT-PCR. Results: cellular proliferation in mature 3T3-L1 adipocytes treated with CCF plus PIO combination during 0.5, 6 and 24 hours, were not affected however, high CCF concentrations decreased cell proliferation. The combined treatment decreased fat accumulation, as well as increases glycerol release with CCF plus PIO-treated adipocytes. Key adipogenic genes were down-regulated (CEBP-ÃŽÂ±, SREBP-, PPARÃ¡ÂµÂž) whereas lipogenic genes (PPAR-ÃŽÂ±) were up-regulated at mRNA level. Conclusion: These findings imply that CCF plus PIO induce lipolysis through the expression of PPAR-alpha in adipocytes.
EX- TEA GARDEN TRIBE AND LABOUR MOBILITY: A LOOK AT CHANGING DYNAMISM OF LABOUR IN SONITPUR DISTRICT, ASSAM
Authors: Mech Krishna
Published: June 2022

This paper examines the changing dynamics of labour of the Ex- Tea garden tribe from the Tea garden tribe in the Sonitpur District of Assam. Hence, factors such as migration or labour mobility, social, economic, cultural, and political aspects have been taken into account for understanding the socio-economic contribution of the Ex-Tea garden tribe labour population in the region. The paper also argues that Ex- Tea garden tribe labour despite their distinct identity and socio-economic contribution to the region is overlooked in different aspects of society in the region. This endangers the growth and development of Ex- Tea garden tribe labour community in various fields in the Sonitpur District of Assam.
PROTECTIVE ROLE OF α-MERCAPTO- β-ACRYLIC ACID SUBSTITUTED DERIVATIVES ON OXIDATIVE STRESS, LIPID PEROXIDATION, ANTIOXIDANT ENZYMATIC ACTIVITIES IN CADMIUM TOXICITY INDUCED RAT MODEL
Authors: Bhatnagar Anuj , Arora Sarika , Kumar Singh Raj
Published: June 2022

Objective: Synthesize some new Î±-Mercapto-Î²-acrylic acidsubstituted derivatives, characterize them and investigate their protective role on oxidative stress, lipid peroxidation, antioxidant enzymatic activities and Cd levels in the blood and tissues of cadmium exposed rats. Method: Twenty-four male rats were divided into three groups of eight rats each. The control group received distilled water whereas group II received CdCl2 (1.5 mg/4 ml/body weight) through gastric gavage for 21 days. Group III to Group VI received CdCl2 and was treated with synthesized compounds for 21 days. The lipid peroxidation level, oxidative stress and enzymatic parameters were measured in plasma and tissues (brain, liver and kidney) of all groupsÎ±-Mercapto-Î²-acrylic acidderivatives were significant in reinstate normal blood profile and biochemical enzymatic levels of Cd-induced toxic animals. Result: C4 derivative was most effective by restoring hemoglobin level to 11.05 g/dL and reduced Cd level in blood to 4.64 Âµg/mL as compared to toxic control group. Xanthine oxidase (XO) and Glutathione-S transferase (GST) activities were significantly altered in the plasma and tissues of the CdCl2 induced group as compared with the control group. Total thiol level was significantly (p<0.001) decreased in Î±-Mercapto-Î²-acrylic acidderivatives treated group as compared to cadmium exposed group. Reduction in the MDA level and MPO level was more significant with C4 synthesized compound among other synthesized compounds. Conclusion: Treatment with Î±-Mercapto-Î²-acrylic acidderivatives decreased the cadmium level in blood and tissues in all groups. without any major side effect, Î±-Mercapto-Î²-acrylic acidderivatives were found effective in reducing Cd toxicity in rats. We can conclude that the synthesized Î±-Mercapto-Î²-acrylic acidderivatives are effective against Cadmium toxicity.
ENDODONTIC MANAGEMENT OF RADIX ENTOMOLARISIN PERMANENT MANDIBULAR FIRST MOLAR: A CASE REPORT
Authors:   Department of Conservative Dentistry and Endodontics, M.I.D.S.R. Dental College and Hospital, Latur, Maharashtra, India., Vilas Patil Damini
Published: June 2022

Mandibular first molars show most of the anatomical variations not only in the number of canals but also in the presence of number of roots and their morphology. The presence of additional root either lingually or buccally in addition to two roots is one of the complex morphological variations. Diagnosis, identification, and treatment of these variations needadequate knowledge of root and root canal anatomy and configurations which can contribute to the better outcome. This case report discusses the endodontic treatment of two mandibular first molars with a radix entomolaris (RE), which are rare macrostructures. The prevalence, the external morphological variations, and internal anatomy of the RE are described.
PROSPECTIVE & COMPARATIVE STUDY OF VARIOUS TECHNIQUES USED IN THE MANAGEMENT OF LIVER ABSCESS IN THE BUNDELKHAND AREA
Authors:   Professor and Head, Department of Surgery, M.L.B. Medical College, Jhansi, Uttar Pradesh., Prakash Surya , Purohit Saurabh ,   Associate Professor, Department of Surgery, M.L.B. Medical College, Jhansi, Uttar Pradesh., Omar Shivam ,   Junior Resident, Department of Surgery, M.LB. Medical College, Jhansi, Uttar Pradesh.
Published: June 2022

Background- This study was designed to determine the frequency of various clinical features in liver abscess and to evaluate the outcome of patients treated by medical management or surgical intervention in terms of hospital stay, cavity reduction time, cost and complications. Method- This is prospective comparative study of 85 patients, presented in in outpatient and emergency department of this hospital with the clinical features of liver abscess during the course of 1.5 years ( january 2020 to june 2021) were included. Patients divided in 4 groups on the basis of usg , patients having cavity size < 5cm were included in group A (n=10) and subjected to conservative management only, patients having cavity size > 5cm underwent percutaneous drainage either by needle aspiration group B (n=21) having volume <100ml or by catheter drainage group D (n=39) having vol>100ml with appropriate antibiotic. Patients with ruptured cavity and signs of peritonitis were included in group C (n=15) and laparotomy was done.outcome of the treatments was evaluated in terms of duration of hospital stay, 50% reduction of cavitysize, total /near total reduction of cavity size, success rate, complication rate and cost. ANOVA test was used to analyze the parameters and determine the results. Result- The most common signs and symptoms were, abdominal pain and right hypochondriac tenderness present in 100% and 78.8% of cases respectively. The success rate of catheter drainage is significantly better (>90%) than other groups (p=0.04) and this group also showed earlier 50% cavity reduction time 7. 4 days, complete cavity reduction time 22.4 days least hospital stay 9.7 days, significantly low complication rate 10.2% than others (p=<0.005) and is most cost effective with avg cost of Rs 2100. Conclusion- Among all the interventions percutaneous pig tail insertion with antibiotic coverage is the best way to treat large liver abscess with thick pus. In case of ruptured liver abscess open surgical method is ideal.
INCIDENTALLY DIAGNOSED ADENOCARCINOMA PROSTATE AFTER SURGERY FOR CLINICALLY BENIGN PROSTATOMEGALY A 2 YEARS RETROSPECTIVE STUDY
Authors:   Junior Resident Department of Surgery, M.L.B. Medical College, Jhansi, Uttar Pradesh., Bajpai Madhurya , Kumar Sudhir ,   Professor and Head, Department of Plastic Surgery, M.L.B. Medical College, Jhansi, Uttar Pradesh., Sanwal A.K. ,   Assistant Professor, Department of Urology, M.L.B. Medical College, Jhansi, Uttar Pradesh., Jain Manish ,   Professor, Department of Urology, SAIMS Indore, Madhya Pradesh., Singh Mayank ,   Professor, Department of Radiotherapy, M.L.B. Medical College, Jhansi, Uttar Pradesh., Mahur Sachin ,   Associate Professor, Department of Radiotherapy, M.L.B. Medical College, Jhansi, Uttar Pradesh.
Published: June 2022

Introduction:Prostate cancer (PCa) is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. The worldwide PCa burden is expected to grow to 1.7 million new cases and 499 000 new deaths by 2030 simply due to the growth and aging of the global population. Aims: To incidentally diagnose prostate cancer during TURP or open prostatectomy in patients clinically diagnosed with prostatomegaly with severe Lower urinary tract symptoms (LUTS). Methods:This study â€œIncidental Prostate Cancerâ€ was conducted on 100 patients selectedin Surgery Department at M.L.B. Medical College, Jhansi between January 2020 to June 2021according to the inclusion criteria; patients were first examined clinically followed specific investigation like PSA, Prostate volume measurement before undertaking surgery for Benign prostatic hyperplasia and the resected specimen/chips of prostate were sent for histopathological examination for confirmation of malignancy. Result: The result of this study demonstrated 1 12% incidence of IPC on clinically diagnosed BPH patients. Patientâ€™s age and PSA level were determined to be factors affecting IPC incidence. Compared to other age groups and PSA level groups, IPC incidence was higher in patients aged >60 years and/or with PSA level >4m=ng/mL. A relation between IPC and Gleason GG2 of 50% was determined statistically on histopathological examination. Conclusion: Incidental prostate cancer diagnosis among patients operated for BPH accounts for a significant proportion. PSA levels and patientâ€™s age are valid diagnostic indicators of IPC. Higher Gleason score â€¦â€¦â€¦â€¦ significantly correlated with IPC.
MALE BREAST CANCER: AN INSTITUTIONAL EXPERIENCE
Authors:   Associate Professor, Department of Radiation Oncology, Government Medical College and Cancer Hospital, Aurangabad, Maharashtra 431005., Agrawal Veenu , Shewalkar Balaji ,   Professor and Head, Department of Radiation Oncology, Government Medical College and Cancer Hospital, Aurangabad, Maharashtra 431005., Kaldate Aditi ,   Junior Resident III, Department of Radiation Oncology, Government Medical College and Cancer Hospital, Aurangabad, Maharashtra 431005.
Published: June 2022

Background Breast cancer is less common in males than females and accounts for about 1% of all malignancies among males. The data on this patient population remains largely unexploredpartially in India since the lifetime risk of developing this cancer is unusually low. MethodsThis is a prospective observational study of male patients diagnosed with breast cancer during 2014 to 2021 at a tertiary care teaching hospital in India. Management consisted of surgery (Modified Radical Mastectomy) followed by adjuvant chemotherapy and radiotherapy with or without hormonal therapy. Descriptive statistics were used for analysis. ResultsA total of 22 patients with a mean age of 59 (range 36-85) yearswere included. The primary presenting complaint was subareolar swelling in 15(68.1%)patients. The histology revealed invasive ductal carcinoma in 22(100%) cases. Breast cancer hormone receptor status (ER/PR-positive) was seen in 20(90.9%) patients. The median follow-up was 38 months. A total of 20(90.9%) patients received adjuvant chemotherapy, radiotherapy, and hormonal therapy. The local recurrence was noted in 6(27.3%) patients. The lung andbone metastaseswere seen in 2(9.1%)patients,liver metastases in 1(4.5%)patient, andbilateral breast cancer in 1(4.5%) patient. At the last available visit, 10(45.4%) patients were following up, 9(40.9%) lost to follow up and unfortunately, 3(13.7%) patients were deceased. ConclusionsThe prognosis of patients with male breast cancer at our center was good. Although male breast cancer has similarities to those in women, there are distinct differences that need to be studied to improve treatment outcomes.
JURIDICAL REVIEW OF FOOD PRODUCTS THAT DO NOT INCLUDE AN EXPIRATION DATE IN INDONESIA
Authors:   Associate Professor, Faculty of Law, JenderalSoedirman University, Indonesia., a Suyadi , Afwa Ulil ,   Senior Lecturer, Faculty of Law, JenderalSoedirman University, Indonesia., Kartika Krisnhoe ,   Associate Professor, Faculty of Law, JenderalSoedirman University, Indonesia., Faradz Haedah ,   Associate Professor, Faculty of Law, JenderalSoedirman University, Indonesia., a Sanyoto ,   Associate Professor, Faculty of Law, JenderalSoedirman University, Indonesia.
Published: June 2022

The title of this study is Juridical review of food products that do not include an expiration date. In Indonesia The research method in this study used a normative juridical approach. The results of the study were analyzed using a qualitative normative analysis method. The results of the study indicate that business actors who do not include an expiration date from a private law perspective are violating Article 8 paragraph (1) letter g and letter i of Law Number 8 of 1999 concerning Consumer Protection. Consumers have rights, as evidence in this matter can be seen with the imposition of a criminal sentence in the form of imprisonment and the confiscation of the products that are circulated for destruction, as regulated in Article 62 paragraph (1) in conjunction with Article 8 paragraph (1) letter g and the letter i of the Law. Number 8 of 1999 concerning Consumer Protection. Other regulations governing expired food are Article 97 paragraph (3) of Law Number 18 of 2012 concerning Food and Article 3 paragraph (2) P.P. Number 69 of 1999 concerning Food Labels and Advertisements.
THE CHALLENGES OF HOSPITAL REFORM IN MOROCCO
Authors:   Ibn Tofail University (ENCG), Kenitra, Maroc.Laboratory: Politiques Economiques Et DÃ©veloppement National Et RÃ©gional., Boudallaa Ikram ,   National School of Public Health, Rabat, Morocco., Elkachradi Rachid ,   Cadi Ayyad University, Marrakech, Morocco., Assarag Bouchra ,   National School of Public Health, Rabat, Morocco., Chrifi Hassan ,   National School of Public Health, Rabat, Morocco.,   Ibn Tofail University (ENCG), Kenitra, Maroc.Laboratory: Politiques Economiques Et DÃ©veloppement National Et RÃ©gional., Kadouri Abdillah ,   Ibn Tofail University (ENCG), Kenitra, Maroc.Laboratory: Politiques Economiques Et DÃ©veloppement National Et RÃ©gional.
Published: June 2022

Morocco has experienced a steady stream of reforms, including considerable changes in the health sector. Hospitals have been notably reformed, given their importance and their stakes. As a result, several deep and costly reforms have promoted the modernization of their management and organization to maximize their efficiency. Thus, the hospital reform has improved hospital management by supporting hospital planning capacities and introducing new management tools and control of management processes. However, even when a new managerial impetus is presented in the hospital environment and modernization is established, hospitals still suffer from many dysfunctions. The provision of hospital care in Morocco is even described as inefficient for a certain period. Despite all the reforms, the persistence of several dysfunctions raises questions about the importance of change management based on the construction and development of knowledge among the actors involved in hospital structures. This article adopted a collection and analysis method of several reports of the most recent national institutions available in Morocco and a selection of international literature to clarify this question. Finally, given the complexity of hospitals, a practical knowledge management approach can support hospital actors in embracing change and fostering ideas and knowledge that lead to improved practices and learning organizations.
Catalysts Derived from Thermal Treatments of Hydrocalumite-Type Compounds: Synthesis and Application in Transesterification Reactions
Authors: Prado Roberta , Corrêa Addila , Rodrigues Joyce , Scaldaferri Cristiane , de Sousa Fabiana , Pasa Vânya , Constantino Vera , Pinto Frederico , Tronto Jairo
Published: June 2022

Catalyst performance is a relevant factor in biodiesel production because it can affect the efficiency of the process. This work provides a study of the performance of heterogeneous catalysts for biodiesel production derived from thermal-treated hydrocalumite-type compounds. This work aimed to synthesize and characterize hydrocalumite-type compounds intercalated with chloride and nitrate, evaluate the effect of thermal treatments at different temperatures (500, 600, and 750 °C) on these materials, and assess the performance of these materials as catalysts in the transesterification reactions using soybean oil and methanol. The materials were characterized by X-ray diffraction (XRD), vibrational spectroscopy (Fourier transform infrared with attenuated total reflectance (FTIR-ATR)), thermogravimetric analysis coupled to mass spectrometry (TGA-DSC-MS), specific surface area, and X-ray photoelectron spectroscopy (XPS). The results of the transesterification reactions showed that the thermal-treated materials from the hydrocalumite intercalated with chloride presented high catalytic activity, among them, the thermal-treated material at 750 °C presented the highest conversion to methyl esters.
Abordaje periodístico sobre la adopción de niños en Colombia entre los años 2008 al 2020
Authors: Estrada Jaramillo Lina Marcela , Montes Rodríguez Luisa María , Díaz Bertel Judith Cecilia , Vergara Guzmán Daniela , Saavedra Jaimes Alisson Estefania , Jaramillo González Andrea , Mena Calderón Luisa Fernanda , Zuleta Hurtado Naudin , Gómez Sánchez Karen Johanna , Ospina Melisa Arboleda , Suarez Polanco Silvia Patricia
Published: June 2022

La investigación analizó el abordaje periodístico de la adopción de niños en Colombia entre los años 2008 al 2020, a partir de un rastreo documental y análisis de contenido realizado a partir de la revisión de los medios de comunicación escritos con mayor cobertura y trayectoria en el país (El Espectador, El Tiempo, El Colombiano y Revista Semana). Se obtuvieron 554 artículos periodísticos entre los años 2014 a 2020, teniendo como tema de mayor cobertura los debates del referendo propuesto para excluir a las parejas del mismo sexo y a las personas solteras como pretensos padres adoptantes. Se concluyó que los medios de comunicación no contrastan el contenido informativo con actores sociales directamente vinculados al proceso como los niños, las familias adoptantes y el organismo rector del programa de adopción – ICBF-, poniendo en evidencia que la fuente principal es política a partir de la temática que se discute.
Groundwater quality assessment of north of Iran (Golestan Province) using multivariate factor analysis and GIS techniques
Authors: Nassiri Mohammad , Mehdinejad Mohammad Hadi
Published: June 2022

Groundwater is one of the most important sources of drinking water. Since the quality of water directly influences consumers' health, it is essential to assess the quality of water and related factors. This descriptive-analytical study was performed on physical and chemical variables of water samples collected in the dry and wet seasons during 2006–2020 period. Changes in groundwater quality were investigated by factor analysis (FA) model and geographic information system (GIS) software. Based on factor analysis model, EC, TDS, TH and Mg+2 levels were the most important factors affecting the quality of water. Due to the high level of hardness (dry seasons; 389.4 mg/l and wet seasons; 418.4 mg/l) and sodium in water (dry seasons; 138 mg/l and wet seasons; 158 mg/l), necessary measures should be taken before drinking and agriculture uses. Changes in the water quality were more related to natural factors and human activities. The invasion of saline water into the groundwater aquifers in the study area should be considered.
Degradation of the nonylphenol aqueous solution by strong ionization discharge: evaluation of degradation mechanism and the water toxicity of zebrafish
Authors: Yi Chengwu , Yang Liu , Yi Rongjie , Yu Haijun , Zhang Jianan , Nawaz Muhammad Imran
Published: June 2022

Nonylphenol (NP) is a typical environmental endogenous disrupter with low concentration and high toxicity. This paper describes the mechanism of NP degradation in solution by strong ionization dielectric barrier discharge (SIDBD). Furthermore, the degradation performance of NP by SIDBD was tested by changing the equipment voltage, the initial concentration of NP in aqueous solution, pH, and inorganic ions. Degradation pathways of NP were detected using a high-performance liquid chromatography-mass spectrometer. The biological effects of NP degradation were assessed by detecting indicators of embryonic development in zebrafish (survival rate, fetal movement, heartbeat, the body length, behavior, deformity) and adult fish (sex differentiation, weight, ovarian testes pathological section analysis). The results showed when the input O2 was 5 L/min and the voltage was 3.2 kV, the degradation efficiency of NP can reach 99.0% after 60 min of experiment. Equipment voltage, initial concentration of NP in solution, pH, inorganic ions and other factors can influence the degradation efficiency of NP by DBD. At the higher concentration of NP, the greater influence on embryonic development in zebrafish was noticed. Although the effects of NP on zebrafish sex differentiation were not obvious, it showed significant male weight inhibition and decrease in sperm number.
Removal of 17α-ethynylestradiol and β-estradiol using bench-scale constructed wetlands
Authors: Bliss S. N. , Berger K. , Thieme J. , Maldonado Cobos M. , Nyman M.
Published: June 2022

Aquatic ecosystems have been devastated by the continued persistence of the synthetic estrogen compounds β-estradiol and 17α-ethynylestradiol. Common wastewater treatment methods do not reduce these compounds in effluent below problematic concentrations. An emerging cost-effective solution to this problem is the use of constructed wetlands to remove these estrogen compounds. This study analyzed the ability of duckweed (Lemna minor), water hyacinth (Eichhornia crassipes), and water cabbage (Pistia stratiotes) to remove β-estradiol and 17α-ethynylestradiol through the use of bench-scale constructed wetlands over a 15-week period. Estrogen concentration in water was collected over time along with plant nutrient content, contaminant extractions, and media extractions. Results indicated that estrogen concentration was reduced by the plants and soil media. Duckweed was the most effective at 96% removal, followed by water hyacinth at 72% removal, then water cabbage at 35% removal, and lastly sediment media at 9% removal. This study provides evidence for the ability of constructed wetlands to be used as a means to remove estrogen compounds from wastewater and demonstrates differences in plants removal efficiencies, with duckweed being the most effective of the selected plants.
Características comportamentais e emocionais de crianças escolares
Authors: Rodrigues Júnior Nelson Silva , De Sousa Ibiapina Aline Raquel , Ibiapina Costa Filho Antônio Alberto , Fernandes Márcia Astrês , Cardoso Costa Ana Paula , De Oliveira Layze Braz
Published: June 2022

Objetivo: Identificar e analisar características comportamentais e emocionais de crianças escolares do ensino público. Métodos: Trata-se de um estudo descritivo de delineamento transversal. Para a coleta dos dados aplicou-se o Questionário de Capacidades e Dificuldades (Strenghts and Difficulties Questionnaire), que permite aos pais e professores a identificação das características do desenvolvimento socioemocional das crianças. Resultados: Entre os 387 alunos avaliados, a média de idade encontrada foi de 3,7 anos, com discreto predomínio masculino de 51,7%. A porcentagem de crianças na categoria de desenvolvimento anormal foi de 7,8%. Os cinco eixos mensurados pelo instrumento apresentaram desenvolvimento normal. Conclusão: Evidenciou-se que as crianças possuem desenvolvimento satisfatório e possivelmente uma boa saúde mental.Descritores: Psiquiatria infantil; Serviços de saúde escolar; Comportamento infantil. BEHAVIORAL AND EMOTIONAL CHARACTERISTICS OF SCHOOL CHILDRENObjective: To identify and to analyze behavioral and emotional characteristics of public school children. Methods: This is a descriptive cross-sectional study. For data collection we applied the Strenghts and Difficulties Questionnaire of Capacities and Difficulties, which allows parents and teachers to identify the characteristics of their children’s social and emotional development. Results: Among the 387 students evaluated, the average age found was 3.7 years, with a slight male predominance of 51.7%. The percentage of children in the abnormal development category was 7.8%. The five axes measured by the instrument showed normal development. Conclusion: It was evidenced that children have satisfactory development and possibly good mental health.Keywords: Child psychiatry; School health services; Child behavior. CARACTERÍSTICAS DE COMPORTAMIENTO Y EMOCIONAL DE LOS NIÑOS DE LA ESCUELAObjetivo: Analizar las características conductuales y emocionales de los niños de escuelas públicas. Métodos: Este es un estudio descriptivo de corte transversal. Para la recolección de datos, aplicamos el Cuestionario de Fortalezas y Dificultades de Capacidades y Dificultades, que permite a los padres y maestros identificar las características del desarrollo social y emocional de sus hijos. Resultados: Entre los 387 estudiantes evaluados, la edad promedio fue de 3.7 años, con un ligero predominio masculino del 51.7%. El porcentaje de niños en la categoría de desarrollo anormal fue del 7,8%. Los cinco ejes medidos por el instrumento mostraron un desarrollo normal. Conclusion: Se evidenció que los niños tienen un desarrollo satisfactorio y posiblemente una buena salud mental.Descriptores: Psiquiatría Infantil; Servicios de Salud Escolar; Conducta Infantil.
Práticas complementares ao transtorno do espectro autista infantil: revisão integrativa da literatura
Authors: Viana Ádria Lorena Oliveira , Da Silva Aline Barbosa , De Lima Keyla Beatriz Barradas , De Souza Marcelo Valente , Borges Verena Gabriela Ribeiro
Published: June 2022

Objetivo: O objetivo deste estudo é identificar as práticas complementares ao transtorno do espectro autista infantil (TEA) encontradas em publicações nacional e internacional. Métodos: O presente artigo visa apresentar uma Revisão Integrativa da Literatura (RIL) com enfoque qualitativo e exploratório fundamentada na análise de conteúdo de Laurence Bardin. Resultados: Este estudo mostrou por meio da busca bibliográfica a análise de artigos da literatura nacional e internacional, no que se refere à publicação sistematizada nos periódicos acerca do autismo e as terapias complementares. Conclusão: Se conclui que as práticas complementares contribuem de forma eficaz para o tratamento do TEA, possibilitando um prognóstico e evolução positiva no desenvolvimento físico, motor e na comunicação verbal e não verbal.Descritores: transtorno autístico; cuidados e autismo; terapias complementares e autismo.COMPLEMENTARY PRACTICES TO CHILD AUTISTIC SPECTRUM DISORDER: INTEGRATIVE LITERATURE REVIEWObjective: The objective of this study is to identify the complementary practices to the infantile autism spectrum disorder (ASD) found in national and international publications. Methods: This article aims to present an Integrative Literature Review (RIL) with a qualitative and exploratory focus based on the content analysis of Laurence Bardin. Results: This study showed, through the bibliographic search, the analysis of articles from national and international literature, regarding the systematic publication in journals about autism and complementary therapies. Conclusion: It is concluded that complementary practices contribute effectively to the treatment of ASD, enabling a prognosis and positive evolution in physical, motor development and verbal and nonverbal communication.Descriptors: Autistic disorder; care and autism; Complementary therapies and autism.PRÁCTICAS COMPLEMENTARIAS PARA EL TRASTORNO DEL ESPECTRO AUTISTA INFANTIL: UNA REVISIÓN DE LITERATURA INTEGRADORAObjetivo: El objetivo de este estudio es identificar las prácticas complementarias al trastorno del espectro autista (TEA) que se encuentran en publicaciones nacionales e internacionales. Métodos: Este artículo tiene como objetivo presentar una Revisión Integral de Literatura (RIL) con un enfoque cualitativo y exploratorio basado en el análisis de contenido de Laurence Bardin. Resultados: Este estudio mostró, a través de la búsqueda bibliográfica, el análisis de artículos de literatura nacional e internacional sobre la publicación sistemática en revistas sobre autismo y terapias complementarias. Conclusión: Se concluye que las prácticas complementarias contribuyen de manera efectiva al tratamiento del TEA, permitiendo un pronóstico y evolución positivos en la comunicación física, motora y verbal y no verbal.Descriptores: Trastorno autista; Cuidado y autismo; Terapias complementarias y autismo.
Percepções de enfermeiros sobre Higiene Bucal em Unidades de Terapia Intensiva adulto
Authors: Monteiro Marina , Bendine Gastaldi Andréia , Montezeli Juliana Helena , Rodrigues Milhorini Carolina , Franco da Rocha Aline
Published: June 2022

Objetivo: apreender as percepções de enfermeiros sobre higiene bucal em adultos internados em terapia intensiva. Método: pesquisa qualitativa feita com nove enfermeiros de duas unidades de terapia intensiva adulto de um hospital universitário público de grande porte do Norte do Estado do Paraná, Brasil. Utilizou-se entrevista semiestruturada audiogravada, sendo os dados transcritos e tratados pela análise de conteúdo. Resultados: emergiram duas categorias empíricas: A importância da higiene bucal na visão dos enfermeiros e; O papel do enfermeiro na concretização da higiene bucal. Conclusão: embora os participantes reconheçam a importância da higiene bucal em vários aspectos, ainda há lacunas quanto ao entendimento de seu papel neste cuidado, bem como acerca de sua correta execução e registro no prontuário.Descritores: Unidades de Terapia Intensiva; Higiene Bucal; Enfermagem.NURSES' PERCEPTIONS ABOUT ORAL HYGIENE IN ADULT INTENSIVE CARE UNITSObjective: To understand nurses' perceptions of oral hygiene in adults in intensive care. Methodology: Qualitative research conducted with nine nurses from two adult intensive care units at a large public university hospital in the north of the state of Paraná, Brazil. Semi-structured interviews were conducted with audio recording, transcription and later examined by content analysis. Results: Two empirical categories emerged: The importance of oral hygiene in the view of nurses and; The role of the nurse in achieving oral hygiene. Conclusion: Although the participants recognize the importance of oral hygiene in several aspects, there are still gaps regarding the understanding of its role in this care, as well as about its correct execution and registration in the medical record.Descriptors: Intensive Care Units; Oral Hygiene; NursingPERCEPCIONES DE ENFERMERAS SOBRE HIGIENE ORAL EN UNIDADES DE CUIDADO INTENSIVO PARA ADULTOSObjetivo: comprender las percepciones de las enfermeras sobre higiene bucal en adultos ingresados en cuidados intensivos. Métodología: investigación cualitativa realizada con nueve enfermeras de dos unidades de cuidados intensivos para adultos en un gran hospital universitario público en el norte del estado de Paraná, Brasil. Se utilizaron entrevistas semiestructuradas grabadas en audio, los datos se transcribieron y trataron mediante análisis de contenido. Resultados: surgieron dos categorías empíricas: la importancia de la higiene bucal en opinión de las enfermeras y; El papel de la enfermera en el logro de la higiene bucal. Conclusión: Aunque los participantes reconocen la importancia de la higiene bucal en varios aspectos, todavía hay lagunas en cuanto a la comprensión de su papel en este cuidado, así como su correcta ejecución y registro en la historia clínica. Descriptores: Unidades de Cuidados Intensivos; Higiene Bucal; Enfermería
Rumos da Enfermagem em tempos de incertezas
Authors: Da Silva Manoel Carlos Neri
Published: June 2022

Um agradecimento. É com estas palavras que gostaria de iniciar este último Editorial que tenho o prazer e a honra de escrever como Diretor-presidente da Revista Científica Enfermagem em Foco.
Alterations in mRNA Expression Levels of Tight Junction Proteins in the
Blood Cells of Smokers with or without COPD
Authors: Bhandary Yashodhar Prabhakar , Shaikh Sadiya Bi , Gouda Mahesh Manjunath , Khandhal Irfan , Rahman Tanyeem , Shetty Ashwini
Published: June 2022

Aim:

This study aimed to assess the role of Tight junction proteins (TJPs) and claudins
in smokers with and without COPD compared to healthy individuals.

Background:

Chronic obstructive pulmonary disease (COPD) is a complex chronic respiratory
disease, including various inflammatory mediators. The prime etiological element in the development
of COPD is cigarette smoking. The lung airway epithelium comprises beneficial immunological
barriers to draw in insults, such as environmental particulates, cigarette smoke, etc.
Tight junctions (TJ) connected by transmembrane proteins determine epithelial permeability.
Cigarette smoke is indicated to defect TJ integrity. The possible involvement of the airway epithelium
in the pathogenesis of COPD has recently become apparent; however, its detailed mechanisms
remain elusive. The integrity of airway epithelium is crucial for airway homeostasis; defective
airway barrier activity contributes to COPD.

Objective:

In the present study, the objective was to investigate mRNA expression levels of TJP’s
like TJP-1, TJP-2, TJP-3, Tight junction-associated proteins-1, claudin-1, claudin-3, claudin-4,
claudin-7, claudin-10, claudin-15, claudin-19, and claudin-25 from blood samples of smokers
with COPD and compared them with smokers without COPD and healthy individuals.

Method:

The mRNA expressions were evaluated by the quantitative PCR method.

Results:

The gene expressions of these TJPs were significantly down-regulated, specifically in
COPD patients with a history of smoking (Smokers with COPD). Besides, FEV% was also established
for these patients. Similarly, smokers with COPD showed a significant increase in the
expression levels of transcription factors, like ZEB-1, ZEB-2, PDGFA, and HDGF, compared to
COPD patients without a history of smoking (smokers without COPD) and the healthy subjects.

Conclusion:

In conclusion, cigarette smoke disrupts TJ of the human airway epithelium, and the
transcriptional factors counteract this smoke-induced COPD. Thus, TJPs may serve as protective
elements for airway epithelial homeostasis during COPD.
A Systematic Review of Randomized Clinical Trials on the Efficacy and
Safety of Pitavastatin
Authors: Elnour Asim Ahmed , Sadeq Adel , Farah Farah Hamad , Ramadan Azza , Baraka Mohamed A. , Don Judit , Amoodi Abdulla Al , Sam Kishore Gnana , Mazrouei Nadia Al , Alkaabi Maisoun
Published: June 2022

Background:

A subpopulation of statin users such as subjects with chronic kidney disease (CKD), Human Immune virus (HIV, acute coronary syndrome (ACS), revascularization, metabolic syndrome, and/or diabetes may particularly benefit from pitavastatin pharmacotherapy.

Aim of the systematic review:

The current systematic review aimed systematically evaluate the effect of pitavastatin on primary cardiac events in subjects receiving pitavastatin in comparison to the other four statin members.

Methods:

We have conducted a systematic review on phases III and IV of randomized controlled trials (RCT-s, 11 trials) for subjects with primary cardiac events who have received pitavastatin. Subjects were diagnosed with any type of dyslipidemia (population 4804), who have received pitavastatin (interventions) versus comparator (comparison) with the primary efficacy endpoint of minimization of LDL-C and non-HDL-C, having an increase in HDL-C and/or reduction in major adverse cardiac events (MACE, cardiovascular death, myocardial infarction (fatal/nonfatal), and stroke (fatal/nonfatal) and/or their composite (outcomes). The secondary safety endpoint was the development of any adverse effects.

Results:

In the included trials (11), participants (4804) randomized for pitavastatin or comparator (atorvastatin, pravastatin, rosuvastatin, simvastatin) and followed up for 12 to 52 weeks. In terms of the primary outcome (reduction in LDL-C), pitavastatin 4 mg was superior to pravastatin 40 mg in three trials, while the 2 mg was comparable to atorvastatin 10 mg in four trials and simvastatin 20 and 40 mg in two 2 trials. However, rosuvastatin 2.5 mg was superior to pitavastatin 2 mg in two trials. Pitavastatin increased HDL-C and reduced non-HDL-C at the majority of the eleven trials. Regarding the safety profile, pitavastatin has proved to be tolerated and safe.

Conclusion:

The FDA proven indications of pitavastatin are primary dyslipidemia and mixed dyslipidemia as adjunctive therapy to dietary changes to lower total cholesterol, LDL-C, apolipoprotein B (Apo B), triglycerides (TG), and to increase HDL-C. Pitavastatin might be suitable for subjects with diabetes, ACS (reduced revascularization), metabolic syndrome, CKD, HIV, and subjects with low levels of HDL-C. We highly recommend rational individualization for the selection of statin.
Artificial Intelligence-based Diagnostic Design for Precision Cancer Nanomedicine
Authors: Misra Ranjita , Sampath Malathi
Published: June 2022

Precise nanomedicine has been extensively explored for efficient cancer
imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their
preclinical and clinical explorations. Moreover, an amalgamation of artificial
intelligence with nanomedicine has proven to be a boon in cancer management. Here,
we demonstrate the recent advances in artificial intelligence-based cancer
nanomedicine and discuss their structure-function relationship for smart and efficient
cancer nanomedicine, including various imaging and therapeutic applications. In
particular, the evolving focus, such as tumour incarceration and DNA nanorobot, also
highlights a variety of new strategies for advanced cancer nanomedicine.
Artificial Intelligence-based Nanosensors to Compose the Patient's Cancer Biomarker Profile
Authors: Sampath Malathi , Misra Ranjita
Published: June 2022

To design biomarker diagnostics, unique characteristics of nanotechnology
are utilized. For decades, biomarkers have been used in clinical medicine. The use of
such high-sensitivity nanosensors will provide patients with an earlier diagnosis of the
disease and make major improvements in clinical outcomes. The biomarker profiles
taken from tumor samples of patients and the clinical meta data can provide proficient
management of cancer patients having comparable molecular subtypes. Thus, artificial
intelligence plays a major role in developing advanced diagnostic tools, such as
nanosensors, that focus on identifying the complexity of cancer disease diagnosis,
thereby emerging as a valuable cancer research outcome in the public domain. This
chapter focuses on nanosensors, highlighting their importance for cancer diagnosis
applications.
Ethical Dimensions of Using Artificial Intelligence in Healthcare
Authors: Behura Ajit Kumar
Published: June 2022

Healthcare organisations around the world are dealing with rising costs and
the potential for negative consequences. Similar conditions are faced by the public
owing to deteriorating ethical standards of healthcare systems. Such situations demand
a responsible healthcare scheme that can meet those challenges. All agreed upon the
idea that a significant resolution would- be ‘Artificial Intelligence (AI).
Poskolonial dan Developmentalisme: Telaah Kritis
Authors: Aminuddin M. Faishal
Published: June 2022

The relation between postcolonial theory and developmentalism does not run linearly, but there is a contradictory dialogue space. This article aims to explain the rejection of postcolonial theory to the paradigm and practice of developmentalism through an evaluation of debates in the philosophical realm. This article answers the debates in postcolonial studies, including the theorizing of political economy, development, and international politics. This rejection stems from the fact that developmentalism is considered a new form of colonization in the economic aspect, extending to social, political, and cultural aspects. The results show that the opposition of postcolonial theory to developmentalism can be explained through four discussions as the unit of analysis, which consists of the international trade system, capital distribution schemes, the role of global institutions, and the existence of the state and its people.
ASEAN Digital Masterplan: Responding Cyber Security Dilemma in The Post-Covid Era
Authors: Abdurrohim Muhammad
Published: June 2022

The COVID-19 pandemic has brought people to stay longer to disconnected from the face-to-face world than before and rely on the cyber domain daily. Because of the pandemic, Southeast Asia countries added a new 40 million internet users and in total 400 million internet users in the region. The new environment of interaction in the virtual domain generates the bipolarity of dominant power between the U.S and China to establish how cyberspace needs to regulate. The increasing penetration of internet users in the region creates an opportunity for ASEAN to establish ASEAN digital master plan that aims to accelerate region recovery from the pandemic through cyber cooperation. Despite ASEAN as a regional institution promote openness and freedom of cyber domain among its members, ASEAN member states taking contradiction policy to its regional institution. This research tries to answer why ASEAN member states take contradiction policy to their regional institution. Utilizing government politic model theory and insecurity dilemma concept, the author argues that insecurity dilemma that faced by ASEAN member states shaping its member states taking an opposite policy of connectivity on cyberspace that regional institution digital masterplan aim for.
The Relationship between the Fear of Childbirth and Anxiety during the Covid-19 Pandemic
Authors: Tuncer Sevinç Köse , Alp Yılmaz Figen , Karakurt Papatya , Yıldız Çiltaş Nadire
Published: June 2022

Introduction. The novel coronavirus disease (COVID-19), which emerged in Wuhan, China, in late 2019, has affected the whole world. Pregnant women who are expected to give birth during this period are one of the most important groups affected by these processes.

The aim of this study was to identify the relationship between the fear of childbirth and anxiety among pregnant women during the COVID-19 pandemic.

Materials and Methods. The cross-sectional study was conducted on 181 pregnant women in a city in the eastern region of Turkey between July and November 2020.

Results. Mid-level fear of childbirth was experienced by 44.8% of pregnant women. A positive correlation was found between the average anxiety score of pregnant women and childbirth fear.

Conclusions. The findings of the study will guide healthcare professionals in finding applicable solutions to the problems experienced by pregnant women during the COVID-19 pandemic period.