bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial Synergy between Tourism Resources and Tourism Service Facilities in Mountainous Counties: A Case Study of Qimen, Huangshan, China
Authors: Han Ying , Wang Yingjie , Yu Hu , Luo Wenting , Wang Kai , Sui Chunhua
Published: July 2024

Under the influence of mountainous terrain, the spatial synergy between tourism resources and tourism service facilities has emerged as a pivotal factor affecting the overall efficiency enhancement of regional tourism destinations. In order to explore the synergistic effect of the two, taking Qimen County as the study site, this study utilizes Point of Interest (POI) data of tourism resources and tourism service facilities. It constructs a fine-scale multidimensional spatial synergy methodology based on grid vectorization to conduct scenario-based comparative analyses of altitude and population density. The objective is to elucidate the effects of fine-scale tourism development synergy and propose enhancement strategies. The findings are as follows: (1) The vertical zonation of mountains has led to a widespread, decentralized distribution of natural tourism resources in mid-to-high-altitude areas, while humanistic tourism resources in low-altitude urbanized areas exhibit a granular, clustered distribution. These contrasting scenarios manifest a polarization, making it difficult to achieve supply–demand matching of the layout pattern of tourism service facilities along transportation routes. (2) The spatial gradient effect of the synergy between the two in mountainous counties is significant, with a higher synergy level in core towns and obvious misalignment in peripheral areas. (3) Altitude and population density are critical factors influencing the supply of tourism service facilities. Through scale aggregation guidance and cost–benefit mechanisms, the spatial distribution can be classified, stratified, and optimized to better serve resource development. This study provides valuable insights into understanding laws governing development and utilization within mountainous county areas for academic research purposes.
The Current Role of Contrast-Enhanced Ultrasound (CEUS) in the Diagnosis and Staging of Bladder Cancer: A Review of the Available Literature
Authors: Santarelli Valerio , Rosati Davide , Canale Vittorio , Salciccia Stefano , Di Lascio Giovanni , Bevilacqua Giulio , Tufano Antonio , Sciarra Alessandro , Cantisani Vito , Franco Giorgio , Moriconi Martina , Di Pierro Giovanni Battista
Published: July 2024

Contrast-enhanced ultrasound (CEUS) is an advanced imaging technique that integrates conventional US with the intravenous injection of specific US contrast agents (UCAs), combining the non-invasiveness of US with the higher accuracy of contrast-enhanced imaging. In contrast with magnetic resonance imaging (MRI), computed tomography (CT) and cystoscopy, CEUS has few contraindications, and UCAs are non-nephrotoxic agents that can be safely used in patients with kidney failure. CEUS is a well-established method for the detection of liver lesions and for echocardiography, and its indications are expanding. The updated 2018 WFUMB-EFSUMB guidelines have added the urinary bladder under non-hepatic applications of CEUS. The technique is able to distinguish between benign tissue, such as clots or hematoma, and malignant lesions by perfusing the mass with contrast agent. Thanks to the different perfusion rates of the various layers of the bladder wall, CEUS is also able to predict tumor invasion depth and stage. Despite that, current urological guidelines do not include CEUS as a plausible imaging technique for bladder urothelial carcinoma. The main reason for this omission might be the presence of scarce randomized evidence and the absence of large validated series. In this review, we describe the rationale behind the use of CEUS in bladder cancer and the added value of this imaging technique in the detection and staging of bladder lesions. In addition, we researched the available literature on the topic and then described the results of randomized clinical trials and a meta-analysis investigating the accuracy of CEUS in bladder cancer diagnosis and staging. The reported studies show that CEUS is a highly accurate diagnostic and staging tool for BC, reaching levels of specificity and sensitivity in differentiating between Ta-T1, or low-grade BC, and T2, or high-grade BC, that are comparable to those shown by the reference standard methods. Nonetheless, several limitations were found and are highlighted in this review. The aim of this study is to further validate and promote the use of CEUS as a quick, economic and effective diagnostic tool for this high-impact disease.
A New Postoperative Stability Score to Predict Loss of Reduction in Intertrochanteric Fractures in Elderly Patients
Authors: Sun Shih-Heng , Chen Chun-Yu , Lin Kai-Cheng
Published: July 2024

The study aimed to validate a newly developed postoperative stability score for evaluating clinical follow-up in elderly patients with low-energy hip fractures. From 1 January 2020 to 31 December 2021, we enrolled patients aged over 65 who underwent cephalomedullary nail fixation using proximal femoral nail antirotation II (PFNAII) and had at least 6 months of follow-up; excluding multiple fractures, pathological fractures, and periprosthetic fractures. We collected general patient data. Parameters such as TAD, Parker’s ratio (AP and lateral), and the new postoperative stability score were recorded. A loss of reduction was defined using the decline in the Chang reduction quality criteria (CRQC) score within one month. Among the 108 enrolled patients, 23 (21.3%) experienced a loss of reduction, with a mean age of 82.1 years and a mean follow-up time of 7.4 months. Univariate analysis showed no significant association between loss of reduction and general data. However, the new postoperative stability score correlated significantly with loss of reduction (mean scores: 6.68 vs. 4.83, p = 0.045). Multivariate analysis confirmed this association (odds ratio: 0.076, 95% confidence interval: 0.022–0.263, p < 0.05). The newly developed postoperative stability score, incorporating surgical technique assessment, improves prediction accuracy for loss of reduction in elderly intertrochanteric fracture (ITF) patients.
Modelling of Static and Dynamic Elastomer Friction in Dry Conditions
Authors: Kaiser Fabian , Savio Daniele , Bactavatchalou Ravindrakumar
Published: July 2024

Understanding the tribological behavior of elastomers in dry conditions is essential for sealing applications, as dry contact may occur even in lubricated conditions due to local dewetting. In recent decades, Persson and co-authors have developed a comprehensive theory for rubber contact mechanics and dry friction. In this work, their model is implemented and extended, particularly by including static friction based on the bond population model by Juvekar and coworkers. Validation experiments are performed using a tribometer over a wide range of materials, temperatures and speeds. It is shown that the friction model presented in this work can predict the static and dynamic dry friction of various commercial rubber materials with different base polymers (FKM, EPDM and NBR) with an average accuracy of 10%. The model is then used to study the relevance of different elastomer friction contributions under various operating conditions and for different roughness of the counter surface. The present model will help in the development of novel optimized sealing solutions and provide a foundation for future modeling of lubricated elastomer friction.
Cloud-Based Remote Real-Time Monitoring and Control System for Spring Fatigue Testing Machine
Authors: Wang Guoshuai , Xu Tonghui , Wang Decheng , Cheng Peng , Shao Chenxi , Feng Feng , Zhou Peng
Published: July 2024

In recent years, the utilization of cloud technology has witnessed a surge, particularly in the domains of industrial automation and intelligent scenarios. However, the prevailing spring fatigue testing machine is still in the traditional single-machine working mode. In this mode, there are many problems such as low automation of testing equipment, poor experimental site environment, and the need for experimenters to be on duty for a long time. In order to solve the above problems, this paper builds a cloud-based remote monitoring and control system based on the high-temperature constant-force spring fatigue testing machine. The system is based on Browser/Server architecture, and clients can access it anytime and anywhere using a browser in a public network environment. The server is hosted on a public cloud platform and includes website service, data storage service, WebSocket real-time communication service, and remote video monitoring service. Clients can remotely monitor and control the testing machine in real time through the cloud. After experimental verification, the real-time monitoring and control messages delay is 11 ms, and the video monitoring delay is 291 ms, which can meet the actual needs of remote spring fatigue testing. This remote monitoring and control system improves the automation of the spring fatigue testing machine and improves the working environment of the experimenters. In addition, it can be applied to other reliability testing machines in the laboratory, and can further help build a workshop-level remote monitoring and control platform.
Preparation and Property Modulation of Multi-Grit Diamond/Aluminum Composites Based on Interfacial Strategy
Authors: Wu Hao , Yang Sen , Chen Yang , He Xiaoxuan , Wang Changrui
Published: July 2024

The development of electronic devices has a tendency to become more complicated in structure, more integrated in function, and smaller in size. The heat flow density of components continues to escalate, which urgently requires the development of heat sink materials with high thermal conductivity and a low coefficient of expansion. Diamond/aluminum composites have become the research hotspot of thermal management materials with excellent thermophysical and mechanical properties, taking into account the advantages of light weight. In this paper, diamond/Al composites are prepared by combining aluminum as matrix and diamond reinforcement through the discharge plasma sintering (SPS) method. The micro-interfacial bonding state of diamond and aluminum is changed by adjusting the particle size of diamond, and the macroscopic morphology performance of the composites is regulated. Through this, the flexible design of diamond/Al performance can be achieved. As a result, when 150 μm diamond powder and A1-12Si powder were used for the composite, the thermal conductivity of the obtained specimens was up to 660.1 W/mK, and the coefficient of thermal expansion was 5.63 × 10−6/K, which was a good match for the semiconductor material. At the same time, the bending strength is 304.6 MPa, which can satisfy the performance requirements of heat-sinking materials in the field of electronic packaging.
First Description of Mycoplasma agalactiae Anatomical Localization in Naturally Infected Hard Ticks (Rhipicephalus bursa)
Authors: Migliore Sergio , Condorelli Lucia , Galluzzo Paola , Galuppo Lucia , Corrente Angelica , Lepri Elvio , Ridley Anne , Loria Guido Ruggero , Puleio Roberto
Published: July 2024

Mycoplasma agalactiae (Ma) is considered the primary causative agent of contagious agalactia (CA) in sheep and goats, which causes severe losses to the small ruminant dairy industry. As early as 1816, it was thought that environmental factors played a role in pathogen maintenance in endemic areas. Specifically, recent studies hypothesized a vector role for arthropods in the epidemiology of disease. The aim of this study was to investigate the presence and anatomical localization of Ma in naturally infected Riphicephalus bursa ticks to better evaluate tick–pathogen interactions. Salivary glands and ovaries of confirmed Ma-positive R. bursa were analyzed to look for the Ma antigen using immunohistochemistry (IHC). IHC showed strong positivity to Ma in the cytoplasm of salivary cells as well as in cells from the ovary. Our work demonstrated for the first time the crossing of the tick midgut barrier by Ma and the subsequent infection of organs capable of spreading the infection, and this result represents an absolute novelty in disease-related knowledge. Our preliminary results provide conclusive evidence of the potential vector role represented by hard ticks in the epidemiology of CA. Further field and laboratory investigations are necessary to confirm the tick role in the transmission of clinical CA.
Molecular, Genetic, and Biochemical Characterization of OXA-484 Carbapenemase, a Difficult-to-Detect R214G Variant of OXA-181
Authors: Gonzalez Camille , Oueslati Saoussen , Rima Mariam , Nermont Réva , Dortet Laurent , Hopkins Katie L. , Iorga Bogdan I. , Bonnin Rémy A. , Naas Thierry
Published: July 2024

OXA-244, an R214G variant of OXA-48, is silently spreading worldwide likely because of difficulties in detection using classical screening media. Here, we characterized two clinical isolates of Escherichia coli and Citrobacter youngae that displayed reduced susceptibility to carbapenems but were lacking significant carbapenemase activity as revealed by negative Carba NP test results. However, positive test results were seen for OXA-48-like enzymes by lateral flow immunoassays. WGS revealed the presence of a blaOXA-181-like gene that codes for OXA-484, an R214G variant of OXA-181. BlaOXA-484 gene was located on a 58.4-kb IncP1-like plasmid (pN-OXA-484), that upon transfer into E. coli HB4 with impaired permeability, conferred carbapenem and temocillin resistance (MICs > 32 mg/L). E. coli TOP10 (pTOPO-OXA-484) revealed reduced MICs in most substrates as compared to E. coli TOP10 (pTOPO-OXA-181), especially for imipenem (0.25 mg/L versus 0.75 mg/L) and temocillin (16 mg/L versus 1028 mg/L). Catalytic efficiencies of OXA-484 were reduced as compared to OXA-181 for most ß-lactams including imipenem and temocillin with 27.5- and 21.7-fold reduction, respectively. Molecular modeling confirmed that the salt bridges between R214, D159, and the R1 substituent’s carboxylate group of temocillin were not possible with G214 in OXA-484, explaining the reduced affinity for temocillin. In addition, changes in active site’s water network may explain the decrease in hydrolysis rate of carbapenems. OXA-484 has weak imipenem and temocillin hydrolytic activities, which may lead to silent spread due to underdetection using selective screening media or biochemical imipenem hydrolysis confirmatory tests.
Anti-Leishmania amazonensis Activity of Morolic Acid, a Pentacyclic Triterpene with Effects on Innate Immune Response during Macrophage Infection
Authors: de Souza Vanessa Maria Rodrigues , Maciel Nicolle Barreira , Machado Yasmim Alves Aires , de Sousa Julyanne Maria Saraiva , Rodrigues Raiza Raianne Luz , dos Santos Airton Lucas Sousa , Gonçalves da Silva Maria Gabrielly , Martins da Silva Ingrid Gracielle , Barros-Cordeiro Karine Brenda , Báo Sônia Nair , Tavares Josean Fechine , Rodrigues Klinger Antonio da Franca
Published: July 2024

Leishmaniasis is a group of infectious diseases transmitted to humans during vector bites and caused by protozoans of the genus Leishmania. Conventional therapies face challenges due to their serious side effects, prompting research into new anti-leishmania agents. In this context, we investigated the effectiveness of morolic acid, a pentacyclic triterpene, on L. amazonensis promastigotes and amastigotes. The present study employed the MTT assay, cytokine analysis using optEIATM kits, an H2DCFDA test, and nitric oxide dosage involving nitrite production and Griess reagent. Morolic acid inhibited promastigote and axenic amastigote growth forms at IC50 values of 1.13 µM and 2.74 µM, respectively. For cytotoxicity to macrophages and VERO cells, morolic acid obtained respective CC50 values of 68.61 µM and 82.94 µM. The compound causes damage to the parasite membrane, leading to cellular leakage. In the infection assay, there was a decrease in parasite load, resulting in a CI50 of 2.56 µM. This effect was associated with immunomodulatory activity, altering macrophage structural and cellular parasite elimination mechanisms. Morolic acid proved to be an effective and selective natural compound, making it a strong candidate for future in vivo studies in cutaneous leishmaniasis.
Quantitative Characterization of Pore–Fracture Structures in Coal Reservoirs by Using Mercury Injection–Removal Curves and Permeability Variation under Their Constraints
Authors: Jiang Xuchao , Miao Bin , Zhang Junjian , Xi Danyang , Qin Zhenyuan , Vandeginste Veerle
Published: July 2024

Pore and fracture structure heterogeneity is the basis for coalbed methane production capacity. In this paper, high-pressure mercury intrusion test curves of 16 coal samples from the Taiyuan Formation in the Linxing area are studied. Based on the fractal dimension values of mercury intrusion and retreat curves, the correlation between the two different fractal parameters is studied. Then, the permeability variation of different types of coal samples is studied using overlying pressure pore permeability tests. The correlation between the permeability variation of coal samples and dimension values is explored, and the results are as follows. (1) Based on porosity and mercury removal efficiency, all coal samples can be divided into three types, that is, types A, B, and C. Among them, Type A samples are characterized by lower total pore volume, with pore volume percentages ranging from 1000 to 10,000 nm not exceeding 15%. (2) During the mercury injection stage, both the M-model and S-model can reflect the heterogeneity of seepage pore distribution. In the mercury removal stage, the M-model cannot characterize the heterogeneity of pore size distribution in each stage, which is slightly different from the mercury injection stage. (3) The permeability of Type A samples is most sensitive to pressure, with a permeability loss rate of up to 96%. The original pore and fracture structure of this type of coal sample is relatively developed, resulting in a high initial permeability. (4) There is no significant relationship between compressibility and fractal dimension of mercury injection and mercury removal, which may be due to the comprehensive influence of pore structure on the compressibility of the sample.
All as σκύβαλα beside the μέγιστον τῶν ἀγαθῶν: Philippians 3:7–11 in Dialogue with Epictetus
Authors: Wilson Laurie A.
Published: July 2024

In Philippians 3:8, Paul holds all things to be loss (ζημία) and even dung (σκύβαλον) in comparison with Christ. Similarly, beside a precise conception of the good (ἀγαθὸν), Epictetus considers earthly achievements and physical benefits as “indifferents” (ἀδιάφορα), which he defines as things that are neither good nor evil. This paper employs a comparative analysis of Paul and Epictetus to examine the tension inherent in both authors as they seek to explain the sufferings and enjoyments of human existence in light of humankind’s ultimate end. Despite Paul’s strong language, he still recognizes the value of temporal goods, including release from prison, recovery from illness, and financial assistance. Thus, a person can value these benefits when they are joined to the greatest good, as illustrated by Augustine’s conception of ordered loves. Like Paul, Epictetus affirms the lesser value of indifferents, particularly when they enable participation in the good. This paper argues that both Paul and Epictetus acknowledge a secondary value in things that are joined to the supreme good, but that Paul differs from Epictetus in classifying them as goods that can be rightly desired and in acknowledging temporary sufferings to be an evil even as they can bring about good.
A Conceptual Model of Rural Tourism in Bali to Build Up Global Competitiveness
Authors: Wiranatha Agung Suryawan , Suryawardani I Gusti Ayu Oka , Purbanto I Gusti Raka , Yudiastina I Gusti Bagus Arya , Bantacut Tajuddin
Published: July 2024

Rural tourism, in the form of small-scale, locally owned tourism businesses, has become a priority that must be supported by the government to be more beneficial for the local community. The objective of this study was to develop a conceptual model of rural tourism in order to make rural tourism in Bali more competitive globally. This research was conducted in Bali during April–June 2020 by following a systems thinking approach. The methodology employed was a soft systems methodology and utilized interpretive structural modeling (ISM). Twenty persons were chosen purposively as key informants (experts). Data collection was carried out through focus group discussions (FGDs) and questionnaires. The results indicated that the goals of sustainable rural tourism are to improve local community welfare, to conserve the environment, and to preserve culture and heritage. Managing rural tourism requires efforts in destination quality, service excellence, hospitality, reasonable pricing, and ease of access. Finally, this paper proposes methods to support sustainable rural tourism in Bali.
HUB3D: Intelligent Manufacturing HUB System
Authors: Trejo-Morales Antonio , Franco-Urquiza Edgar Adrián , Devilet-Castellanos Hansell David , Bringas-Posadas Dario
Published: July 2024

HUB3D represents a cutting-edge solution for managing and operating a 3D printer farm through the integration of advanced hardware and software. It features intuitive, responsive interfaces that support seamless interaction across various devices. Leveraging cloud services ensures the system’s stability, security, and scalability, enabling users from diverse locations to effortlessly upload and manage their 3D printing projects. The hardware component includes a purpose-built rack capable of housing up to four 3D printers, each synchronized and managed by a manipulator arm controlled via Raspberry Pi technology. This setup facilitates continuous operation and high automation, optimizing production efficiency and reducing downtime significantly. This integrated approach positions HUB3D at the forefront of additive manufacturing management. By combining robust hardware capabilities with sophisticated software functionalities and cloud integration, the system offers unparalleled advantages. It supports continuous manufacturing processes, enhances workflow efficiency, and enables remote monitoring and management of printing operations. Overall, HUB3D’s innovative design and comprehensive features cater to both individual users and businesses seeking to streamline 3D printing workflows. With scalability, automation, and remote accessibility at its core, HUB3D represents a pivotal advancement in modern manufacturing technology, promising increased productivity and operational flexibility in the realm of additive manufacturing.
Research on Experimental and Simulated Temperature Control Performance of Power Batteries Based on Composite Phase Change Materials
Authors: Dong Yanchao , Ma Xiaozhong , Wang Chao , Xu Yuejuan
Published: July 2024

The power battery is a key component of electric vehicles and its performance is greatly affected by temperature. Battery thermal management systems based on phase change materials can effectively control the battery temperature and at the same time have the advantages of simple structures, energy savings, and good temperature uniformity, and has broad development prospects. In this paper, expanded graphite–paraffin composite phase change materials were prepared, phase change material cooling experiments were carried out, and a phase change material cooling simulation model was also established using the Fluent software to study the influence of phase change material thermophysical parameters on thermal management performance. The results show that the phase change material thermal management method has excellent cooling performance. The best thermal management performance is achieved at the 3C discharge rate, with a phase change material filling thickness of 4 mm, a melting point of 40 °C above ambient temperature, and a thermal conductivity of 3 W/(m·K). When the phase change latent heat was increased from 150 J/g to 250 J/g, the liquid phase ratio decreased from 0.84 to 0.51, and the subsequent cooling performance was greatly improved, so the phase change latent heat should be increased as much as possible.
Sanctions internationales unilatérales et contre-mesures
Authors: Beaucillon Charlotte
Published: July 2024

Can unilateral international sanctions be equated with countermeasures in international responsibility law ? The question is an old one. The result of a semantic and conceptual shift that has taken place over the last forty years in the light of the mechanisms highlighted in this article, the theoretical assimilation between international sanctions and countermeasures is, however, only very imperfectly verifiable in practice. The analysis therefore sets out in search of countermeasures in a field that is constantly expanding, and distinguishes, following the logic of the international law of responsibility, between international sanctions that could be assimilated to the logic of countermeasures adopted by an injured subject, and those adopted by a non-injured subject. While the former, on the one hand, disappear purely and simply, between factual obsolescence and legal novation, the latter, on the other hand, suffer from persistent unjusticiability and controversy. Having shown that the theoretical assimilation between international sanctions and countermeasures has hardly been sufficient to contain the residual manifestations of private justice mechanisms based on the unilateral adoption of unarmed coercive measures, the article concludes by opening up a recast field of research articulated around new questions.
Les ‘sanctions’ de l’Union européenne contre les États tiers
Authors: Dreysse Daphné
Published: July 2024

L’Union européenne a développé une large pratique de sanctions dirigées contre des États tiers, parmi laquelle les mesures restrictives prévues à l’article 215 du TFUE occupent aujourd’hui une place prépondérante. La tendance actuelle montre un accroissement de cette pratique des sanctions, conçue comme un outil privilégié de politique extérieure. Pourtant, et malgré cette pratique quantitativement importante, il existe encore de nombreuses incertitudes concernant ces mesures. Les mesures restrictives (sanctions) de l’Union européenne sont des mesures réactionnelles à finalité modificative. En effet, elles permettent à l’Union de réagir à des nombreuses situations factuelles se déroulant sur le territoire d’un État tiers et qui présentent pour point commun de heurter ses valeurs (principalement le respect des droits de l’homme et le respect du droit). L’Union cherche alors à faire pression sur l’État tiers (les autorités ou les personnes proches du pouvoir) pour que la situation factuelle change dans un sens déterminé. Ces mesures qui prennent naissance dans l’appréciation subjective et unilatérale d’une situation factuelle intéressent le droit international de manière incidente. À l’exception de l’interdiction du recours à la force, le droit international public laisse ses sujets réagir – et interagir – comme ils l’entendent, sous réserve de respecter les obligations internationales qu’ils ont choisi d’assumer par ailleurs.
Le retrait de ratification d’un traité non encore entré en vigueur
Authors: Hajjami Nabil
Published: July 2024

RLe régime juridique attaché au retrait de la ratification d’un traité qui n’est pas encore entré en vigueur a assez peu intéressé la doctrine internationaliste. Ce sujet, s’il n’emporte certes pas d’incidences pratiques considérables en raison d’un nombre de précédents très limité, soulève d’importantes questions de fond, notamment au regard des principes de bonne foi et de liberté contractuelle. L’objet de cet article sera de montrer qu’un droit au retrait de la ratification d’un traité, dans l’attente de son entrée en vigueur, existe. L’acte de ratification ne saurait, en effet, s’analyser comme un engagement irrévocable de devenir partie au traité. En revanche, ce droit ne saurait s’exercer de façon inconditionnelle et sa mise en œuvre doit, notamment, préserver les droits des autres parties au traité.
« L’arrêt de la Cour européenne des droits de l’homme dans l’affaire Géorgie contre Russie (II) : les limites de la Cour comme organe de contrôle du droit international humanitaire »
Authors: Van Steenberghe Raphaël
Published: July 2024

Le 21 janvier 2021, la Cour européenne des droits de l’homme rendait son arrêt dans l’affaire Géorgie contre Russie (II) . Dans sa requête, la Géorgie reprochait à la Russie diverses violations de la Convention européenne des droits de l’homme commises dans le cadre du conflit armé ayant éclaté en août 2008 et l’ayant opposée à l’armée russe et aux forces sud-ossètes et abkhazes. La Cour s’est prononcée sur deux principales questions, celle de la juridiction de la Russie en territoire géorgien et celle de la responsabilité de celle-ci en raison des violations de la Convention. Elle a procédé à l’examen de ces questions en distinguant différents aspects de la requête, dont principalement la «phase active des hostilités », ayant duré cinq jours jusqu’à la conclusion du cessez-le-feu, et la «phase d’occupation », ayant directement succédé à cette période. Si la Cour a conclu à la juridiction et à la responsabilité de la Russie en ce qui concerne la plupart des aspects de la requête, son raisonnement et ses conclusions demeurent contestables à divers égards. Il en va ainsi principalement des arguments, peu concluants, qu’elle a développés pour justifier l’absence de juridiction de la Russie par rapport à la phase active des hostilités. Il en va de même des références, peu étayées, au droit international humanitaire qu’elle a pris en compte au stade de son étude des violations de la Convention. Ces lacunes apparaissent comme autant de limites à la volonté ou à la capacité de la Cour d’agir comme organe de contrôle du droit international humanitaire, alors qu’il était souhaitable pour les victimes qu’elle joue pleinement ce rôle dans le cadre de son examen du respect de la Convention en temps de conflit armé, en raison de l’absence de mécanisme efficace de mise en œuvre du droit international humanitaire.
« Délimitation maritime dans l’océan Indien (Somalie c. Kenya). L’arrêt sur le fond rendu le 12 octobre 2021 »
Authors: Müller Daniel
Published: July 2024

L’arrêt de la Cour internationale de Justice rendu le 12 octobre 2021 tranche les questions de fond dans l’affaire relative à la Délimitation maritime dans l’océan Indien entre la Somalie et le Kenya. L’affaire a été marquée par une fin de procédure chaotique, une procédure orale retardée et la non-comparution du Kenya. Sur le fond, l’arrêt de la Cour reste classique et constitue une confirmation importante de la jurisprudence internationale en matière de délimitation maritime, y compris en ce qui concerne la question de la responsabilité d’un État en raison d’activités menées dans les espaces marins contestés. La décision soulève néanmoins quelques interrogations et problèmes, notamment en ce qui concerne l’application concrète de la méthode de délimitation et la délimitation de la partie du plateau continental au-delà de la limite de 200 milles marins.
La perte de conteneurs en mer
Authors: Piette Gaël
Published: July 2024

Qui ne s’est ému du spectacle navrant de ces conteneurs qui tombent à la mer, parfois par dizaines ou centaines ? Le droit de la mer et le droit maritime s’efforcent de fixer un cadre juridique à la perte de conteneurs en mer. Des mécanismes préventifs existent et, parce que la prévention ne suffit pas toujours, le droit organise la récupération des conteneurs perdus et la responsabilité susceptible d’en résulter. Malgré ses qualités, le système mis en place demeure perfectible, en particulier en ce qui concerne la haute mer. Une piste de réflexion pourrait consister en la création d’une Autorité internationale de la haute mer.
Application of Geographically Weighted Logistic Regression in Modeling the Human Development Index in East Java
Authors: Saifudin Toha , Panjaitan Leni Sartika , Falasifah Sabrina , Yan Dwi
Published: July 2024

Main Objectives: pinpoint the factors influencing HDI, taking into consideration location and spatial factors. Problems: The Human Development Index (HDI) in East Java often fails to reflect actual conditions accurately, as disparities exist among districts and cities, with some falling below government expectations. Novelty: GWLR extends logistics regression by incorporating spatial factors, allowing for the identification of regional differences and influential factors affecting HDI based on actual data. Methods: To address this issue, the Geographically Weighted Logistic Regression (GWLR) method is employed. The independent variables used are Expected Years of Schooling (X1), Open Unemployment Rate (X2), and Morbidity Rate ( X3) in 2021, while dependent variable is the Human Development Index (Y). Finding/Results: The study reveals that GWLR provides a superior model compared to Ordinary Logistic Regression, indicated by a lower Akaike Information Criterion (AIC) of 28.72. Additionally, the GWLR model with Fixed Gaussian Kernel weights outperforms other weighting methods. At 90% confidence level, the significant variables influencing HDI are expected years of schooling (X1) and the open unemployment rate (X2). Given the relatively low HDI in Indonesia, the East Java Government should focus on improving these key areas to enhance HDI across districts and cities in the region.
Digital Literacy in Mediating the Influence of Education, Demography, Employment on Poverty
Authors: Liswanda Satria , Oktavia Rini , Zuhra Rahma
Published: July 2024

This study investigated the influence of education, demography, and employment on poverty with digital literacy as a mediating variable. A structural Equation Modeling (SEM) with the Partial Least Square (PLS) method was applied. Significant indicators found are four indicators of education and digital literacy variables, two indicators of demographic and employment variables, and three indicators of poverty variables. It was found that education and employment variables had a significant influence on poverty with a negative influence. We found that no variable has a significant effect on digital literacy and there is no significant effect of digital literacy on Poverty.
The KLC Cultures' Synergy Power, Trust, and Tacit Knowledge for Organizational Intelligence
Authors: Kucharska Wioleta , Bedford Denise
Published: July 2024

This paper examines the impact of knowledge, learning, and collaboration cultures synergy (the KLC approach) on organizational adaptability. The SEM analysis method was applied to verify the critical assumption of this paper that the KLC approach supports knowledge-sharing processes (tacit and explicit) and that both matter for organizational intelligence activation.
The empirical evidence, based on a 640-case sample composed of Polish knowledge workers, exposed that knowledge sharing, organizational intelligence, and innovativeness are vital benefits of the KLC cultures’ synergy and showed that trust among workmates is critical to sustaining tacit knowledge sharing in an organization. Tacit knowledge is clearly exposed as an essential ingredient of change adaptability, which is seen as a proxy for organizational intelligence. Moreover, the mistakes acceptance component of learning culture supporting trial-error-learnings is noted as tremendous for knowledge-sharing processes, organizational intelligence (change adaptability), and innovativeness. This study proved that knowledge sharing, organizational intelligence, and innovativeness are vital benefits of the synergy that offers the KLC cultures. Trust strengthens this effect. So, to gain these benefits, knowledge-driven organizations should employ trusted managers who trust others and, in addition to their professional credentials, exhibit strong habits of respecting knowledge, learning, and collaboration.
The modified Stack procedure for central slip reconstruction: a case series
Authors: Warbrick-Smith James , Morris Holly , Collocott Shirley , Wang Amy , Smith Karen L
Published: July 2024

There are many surgical techniques for reconstruction of the divided or incompetent central slip. Most rely upon postoperative immobilisation to protect the repair. We present our experience using a distally based flexor digitorum superficialis slip to reconstruct the central slip and allow early mobilisation in five patients with intact preoperative intrinsic function. Post-treatment, a mean recovery of 65 degrees of active extension was achieved, albeit at the cost of a mean 22-degree loss of active flexion. We suggest this relatively easy technique provides a useful surgical option in the management of this difficult problem.
İdare Hukuku Cephesinden Spor Güvenlik Kurulu Ve Kararları Üzerine Bir Değerlendirme
Authors: Apaydın Bahadır
Published: July 2024

Anayasa’nın ve ilgili spor mevzuatının idareye yüklediği görev ve sorumluluklar kapsamında idarenin, spor etkinliklerinde özerk ve/veya özel hukuk statüsündeki bileşenler ile birlikte hareket etmesi kaçınılmazdır. Bu çerçevede 6222 sayılı Sporda Şiddet ve Düzensizliğin Önlenmesine Dair Kanun ve ilgili yönetmelikler kapsamında merkezi idare içinde İl ve ilçe Spor Güvenlik Kurulları oluşturulmuştur. Spor güvenlik kurulları, spor etkinliklerinde şiddet ve düzensizliğin önlenmesi ve kamu düzeninin korunması amacıyla çeşitli işlemler tesis ederek idari nitelikte kararlar almaktadır. İdarenin kolluk faaliyeti kapsamında tesis edilen spor güvenlik kurulunun işlemlerinin idare hukuku cephesinden değerlendirilmesi gerekmektedir. Bu bağlamda; spor güvenlik kurulunun hukuksal temelleri, görev ve yetkileri, yapısı ve karar alma süreçleri, kararların hukuki niteliği ve yargısal denetimi konuları meselenin irdelenmesi bakımından önem arz etmektedir. Çalışmamızda bahsi geçen konular ilgili mevzuat, örnek kurul kararları ve kazai içtihatlar ışığında ele alınmaya çalışılmıştır. Bu çalışmadaki tespitlerden yola çıkılarak, spor güvenlik kurulu kararlarına ve çalışma usulüne dair bazı öneriler getirilmiştir.
Fabry Disease: A Literature Review, Own Clinical Observation
Authors: Рушкевич Ю.Н. , Труханова И.С. , Лихачев С.А. , Павловская Т.С. , Мальгина Е.В. , Гусина Н.Б. , Колыбенко М.И. , Тищенко Г.В. , Гвищ Т.Г. , Антоненко Д.А. , Клюнчик С.Г.
Published: July 2024

Болезнь Фабри относится к редким Х-сцепленным рецессивным лизосомальным болезням накопления. Для данного заболевания характерна мутация в гене GLA (галактозидаза альфа), что приводит к уменьшению или отсутствию фермента альфа-галактозидазы и накоплению гликосфинголипидов в различных тканях и органах, включая почки, сердце, центральную и периферическую нервные системы. Болезнь Фабри относится к протромботическим состояниям с поражением мелких сосудов неатеросклеротического генеза и является одной из причин развития инсульта. Выделяют 2 фенотипа болезни Фабри: классический и с поздним началом. Чаще встречаются классические формы болезни Фабри. Как правило, диагностируют болезнь Фабри на стадии поражения значимых органов, таких как сердце, почки, нервная система. Лечение болезни Фабри включает в себя ферментозаместительную терапию (агалсидаза альфа и агалсидаза бета) и шаперонную терапию (мегаластат). На стадии клинических испытаний находятся другие методы лечения, такие как субстратная терапия, другие ферментзаместительные средства, генная терапия.

Fabry disease is a rare X-linked recessive lysosomal storage disease. This disease is characterized by a mutation in the GLA (galactosidase alpha) gene, which leads to a decrease or absence of the alpha-galactosidase enzyme and accumulation of glycosphingolipids in various tissues and organs, including the kidneys, heart, central and peripheral nervous system. Fabry disease refers to prothrombotic conditions of non- atherosclerotic origin damaging small vessels, being one of the causes of stroke. There are 2 phenotypes of Fabry disease: classic and late-onset. The classic forms of Fabry disease are more common. As a rule, Fabry disease is diagnosed at the stage of damage to significant organs, such as the heart, kidneys, and nervous system. Treatment of Fabry disease includes enzyme replacement therapy (agalsidase alfa and agalsidase beta) and chaperone therapy (megalastat). Other treatment methods, such as substrate therapy, other enzyme replacement agents, and gene therapy, are in clinical trials.
Subacute Autoimmune Encephalitis as a Result of Asymptomatic COVID-19 Infection: A Case Report
Authors: Малыгин В.В. , Медвецкая Е.Н. , Чернуха Т.Н. , Лихачев С.А. , Титкова Е.В.
Published: July 2024

В статье описан клинический случай подострого аутоиммунного энцефалита как возможного результата перенесенной бессимптомной инфекции COVID-19, проведен обзор литературы, обоснован установленный диагноз. Приведены основные результаты исследований пациента, включая МРТ головного мозга, результаты люмбальной пункции, исследования на возможные инфекции и онкопоиск, описана динамика неврологического статуса на фоне лечения. В результате проведенной иммунной терапии, включающей назначение глюкокортикостероидов, плазмафереза, введение внутривенного иммуноглобулина, наблюдалась значительная положительная динамика состояния пациента. Катамнестические данные указывают на полный регресс симптомов заболевания и отсутствие рецидива в течение 2 лет наблюдения за пациентом. При предъявлении пациентами, перенесшими коронавирусную инфекцию, жалоб неврологического характера должна быть повышенная настороженность на предмет аутоиммунного энцефалита, так как своевременная диагностика и иммунная терапия данного заболевания значительно повышают вероятность его благоприятного исхода.

The article describes a case of subacute autoimmune encephalitis as a possible result of an asymptomatic COVID-19 infection, reviews the literature, and substantiates the diagnosis. The main results of the patient’s examinations, including brain MRI, lumbar puncture results, tests for possible infections and cancer screening, and trends in the neurological status amid treatment are presented. As a result of immune therapy, including glucocorticosteroids therapy, plasmapheresis, and intravenous immunoglobulin infusion, significant positive changes in the patient’s condition were observed. Follow-up data indicate a complete regression of disease symptoms and no relapse during 2 years of the patient’s monitoring. When patients who underwent coronavirus infection present neurological complaints, a higher vigilance for autoimmune encephalitis is required, since timely diagnosis and immune therapy of this disease increase significantly the probability of its favorable outcome.
Pendampingan Manajemen Produk Usaha Bawang Merah dan Cabe Keriting di Kel. Tande Timur Kec. Bangai Timur Kab. Majene
Authors: Syamsuddin Fajar Rakasiwi , Bulkis Bulkis , Anfas Anfas , Nurdiyah Nurdiyah
Published: July 2024

Perkembangan dunia modern menciptakan tekanan yang besar terhadap pelaku usaha dewasa   ini, tak terkecuali Usaha Mikro Kecil Menengah (UMKM). Perubahan teknologi, budaya, dan arus informasi yang cepat menciptakan kompetisi pasar yang begitu hebat. Hal ini cukup  berdampak terhadap daya saing UMKM yang memiliki keterbatasan dari segi teknologi, informasi, dan akses ke dunia luar. Salah satu usaha yang merasakan dampak ini adalah usaha pengoalahan bawang merah dan cabe keriting  yang berada di Kabupaten Majene. Keterbatasan pengetahun terhadap perkembangan dunia modern membuat proses berjalannya usaha pengolahan hasil pertanian bawang merah dan cabe keriting ini semakin sulit bernafas ditengah persaingan yang begitu ketat. Pelaksanaan pengabdian masyarakat ini menyasar pelaku usaha bawang merah dan cabe keriting. Dalam pelaksanaan kegiatan ini, difokuskan pada manajemen produk yang meliputi: pengemasan produk yang bisa meningkatkan daya Tarik produk, manajemen pengolahan yang bisa menciptakan efisiensi, pemasaran produk untuk memperluas jangkauan pemasaran, serta administrasi pembukuan usaha. Kegiatan ini diharapkan bisa meningkatkan daya saing usaha bawang merah dan cabe keriting ditengah ketatnya persaingan produk serupa. Kegiatan yang dilakukan selama kurang lebih dua bulan ini, mendapat respon yang baik dari pelaku usaha serta petani bawang merah dan cabe keriting sekitar.
PEMANFAATAN PEKARANGAN UNTUK TANAMAN OBAT KELUARGA DI KELOMPOK PEREMPUAN GMIT EBENHAEZER TARUS, KABUPATEN KUPANG
Authors: Bulkis Bulkis Bulkis , Sudarso Yos , Fina Yusinta N , Belin Junus J , Nurdiyah Nurdiyah
Published: July 2024

Tanaman obat adalah salah satu tanaman yang dianjurkan untuk dikembangkan di pekarangan. Pemanfaatan pekarangan sebagai sarana budidaya tanaman obat telah dikenal dalam konsep Tanaman Obat Keluarga (TOGA), yaitu tanaman hasil budidaya rumahan yang berkhasiat sebagai obat. Kebiasaan menanam tanaman obat dipekarangan rumah dan pemanfaatanya sudah sejak lama dilakukan oleh para ibu rumah tangga di beberapa daerah di Indonesia. Metode yang digunakan dalam pelaksanaan kegiatan dilakukan penyuluhan tentang jenis – jenis tanaman obat yang mudah dibudidaya dipekarang rumah dan langsung praktik cara pengolahan tanaman obat tersebut, selain dua hal tersebut para jemaat perempuan gmit ebenhaezer tarus diberikan penyuluha tentang pengolahan limah rumah tangga jadi pupuk kompos. Selain itu Tim PKM memberikan bantuan bibit tanaman obat dan alat untuk pengolahan limbah rumahtangga menjadi pupuk kompos. Hasil dari kegiatan ini dilihat dari peserta mampu menerima materi dan respon peserta sangat baik dan sudah mengetahui jenis – jenis tanaman obat yang bisa ditanam di halam rumah, mengetahui cara pengolahannya dan mampu mengolah sampah rumah tangga menjadi pupuk kompos.
PENDAMPINGAN PEMBUATAN CINDERAMATA DALAM PENGEMBANGAN DESA WISATA DI DESA PAPPANDANGAN
Authors: Sukmawati Sukmawati , Rahayu Ayu , Muin Rahma , Haeruddin Haeruddin , Arfandi Adnan Mohammad
Published: July 2024

Pendampingan dalam pembuatan cinderamata merupakan aspek kunci dalam pengembangan desa wisata, khususnya di Desa Pappandangan. Desa Pappandangan memiliki potensi wisata yang beragam, namun belum sepenuhnya dimanfaatkan secara optimal. Penelitian ini bertujuan untuk mengkaji peran pendampingan dalam pembuatan cinderamata sebagai bagian dari strategi pengembangan desa wisata. Hasil menunjukkan bahwa pendampingan dalam pembuatan cinderamata yang terbuat dari rotan memiliki dampak positif yang signifikan terhadap pengembangan desa wisata di Desa Pappandangan. Pendampingan ini tidak hanya meningkatkan keterampilan masyarakat lokal dalam pembuatan cinderamata, tetapi juga meningkatkan nilai tambah produk, pemasaran, dan daya tarik wisata. Selain itu, pendampingan juga memperkuat keterlibatan masyarakat dalam proses pengembangan desa wisata, meningkatkan kesadaran akan pentingnya pelestarian budaya lokal, dan memperkuat ikatan sosial antarwarga. Diharapkan hasil pelatihan ini dapat menjadi sumbangan bagi pengembangan desa wisata secara berkelanjutan di Indonesia.