bluuebunny/crossref_metadata_2025 huggingface dataset:
Lumberjanes e Hilda, serie a fumetti scout tra ecocritica ed ecofemminismo
Authors:   Università di Firenze, Italia, Forni Dalila
Published: December 2022

Among the forms of children’s literature that deal with the complex relationship between humanity and nature, comics can offer various insights on the topic for boys and girls. In particular, children’s stories have recently revitalized the scout movement, interpreting it through new values related to identity, gender and ecology. This paper will consider two comic book series on scouting, Hilda (Luke Pearson, 2011–2019) and Lumberjanes (Noelle Stevenson, 2014–2020). Both works tell the story of a diverse group of characters involved in scouting activities: the stories, developed in natural settings, portray the growth of young and peculiar characters who, through constant contact with the environment, show a strong respect for both nature and the peer group, in a peaceful and adventurous coexistence with the environment and the different forms of life that inhabit it. The essay aims to develop a first state of the art that highlights new interpretative strands in this literary genre through an ecocritical and ecofeminist lens. The study explores the two works in a comparative perspective, so as to show how comic book narratives can present interesting ecological and egalitarian dynamics, in this case through the experience of scouting.
AN ENHANCED FRAMEWORK FOR MORRIS BY COMBINING WITH A SEQUENTIAL SAMPLING STRATEGY
Authors: Li Qizhe , Huang Hanyan , Xie Shan , Chen Lin , Liu Zecong
Published: December 2022

The Morris method is an effective sample-based sensitivity analysis technique that has been applied in various disciplines. To ensure a more proper coverage of the input space and better performance, an enhanced framework for Morris is proposed by considering the combination of a sequential sampling strategy and the traditional Morris method. The paper introduces utilizing progressive Latin hypercube sampling to generate starting points while progressively preserving Latin hypercube property. Then the calculations for Elementary Effects, which occupies the major computational cost of Morris, become sequential. An adaptive stop criterion is also constructed to end the algorithm when the convergence condition is satisfied. Therefore, the proposed procedure makes the cost of Morris more manageable and minimizes the computational burden by conducting only model runs that are necessary to achieve reliable results. Two numerical examples and two real-world cases are given to illustrate the effectiveness and robustness of the framework.
Malagasy N-bonding: A licensing approach
Authors: Ting Connie
Published: December 2022

This paper provides an account of N-bonding in Malagasy, a predicate-initial Austronesian language of Madagascar. N-bonding refers to a morphological process in which material from nominal arguments is morphologically bound to certain heads (Keenan 2000). I argue that N-bonding can be analyzed as a reflection of head-head adjunction configurations which can be derived in Malagasy through Local Dislocation (Embick & Noyer 2007; Levin 2015; Erlewine 2018), a post-syntactic operation that yields a complex head. Following Levin 2015, I assume that Local Dislocation is implemented in Malagasy due to licensing constraints. More specifically, I show that N-bonding occurs in all constructions in which an argument cannot be licensed by the structural mechanisms available in the language. The resulting head-head configuration then feeds a language- specific morphophonological operation that inserts a bundle of features which surface as the N-bonding element. This approach not only accounts for the distribution of N-bonding and is consistent with the observed phonological patterns, but also offers an alternative view of underlying clausal structure and voice morphology in Malagasy.
Kamu Hastanelerinde Teknik Etkinlik: Bir Meta-Regresyon Analizi
Authors: KAYA Neylan , ALGIN Aydolu
Published: December 2022

Bu çalışmanın amacı, kamu hastanelerinin etkinliğinin hesaplanmasında Veri Zarflama Analizini kullanan çalışmaları incelemek ve teknik etkinliklerini etkileyen faktörleri meta-regresyon analizi ile belirlemektir. 1998-2021 yılları arasında yayımlanmış ve dahil etme kriterlerini sağlayan 30 ampirik makale bu çalışmanın örneklemini oluşturmaktadır. Meta-regresyon analizi sonuçlarına göre çalışmaların yayın yılı ve ülkelerin gelir grupları ortalama teknik etkinliği etkilememektedir. Hastane sayısı, değişken sayısı, veri toplama yılı ve ülkenin bulunduğu kıta değişkenleri ortalama teknik etkinlik tahmini üzerinde istatistiksel olarak anlamlıdır. Çalışma, kamu hastanelerinin büyük çoğunluğunun etkinliklerinin optimalin üstünde olduğunu göstermiştir. Bu çalışmanın, sağlık alanındaki politikacılara ve yöneticilere hastanelerin etkinliğinin artması konusunda farkındalık sağlaması beklenmektedir.
Система визуальной навигации в кампусе вуза. Кейс НИУ ВШЭ с размышлениями
Authors: Елисеенко Владимир , Логутова Наталья
Published: December 2022

В книге представлена система визуальной навигации в новом большом комплексе зданий Национального исследовательского университета «Высшая школа экономики» на Покровском бульваре. Издание будет полезно специалистам по дизайну пространств вузов и образовательных учреждений в целом, а также всем, кто занимается построением визуальных систем навигации в общественных пространствах любого типа или заинтересован в создании/модернизации таких систем.
Notes on the nomenclature of Lithospermum (Boraginaceae)
Authors: Cohen James I.
Published: December 2022

Two taxonomic and nomenclatural issues in Lithospermum are addressed. The new combination L. thurberi based on Onosmodium thurberi is made, and L. macromeria (Macromeria viridiflora) is included as a heterotypic synonym. Lithospermum bejariense and Onosmodium bejariense are treated here as two distinct taxonomic entities.
Taxonomic status of Astrophytum mirum (Cactaceae)
Authors: Montanucci Richard R.
Published: December 2022

Astrophytum mirum Halda & Panarotto has a stem morphology that agrees with that of an anomalous growth form of Astrophytum myriostigma subsp. tulense discovered in culture. The flower of A. mirum is indistinguishable from the flower of subsp. tulense. The type locality of A. mirum, now restricted to Mamaleón, Tamaulipas, is situated in the habitat of subsp. tulense. Alleged differences in seed size and root morphology between the two taxa are not confirmed as no examples were preserved with the type material. The conclusion is drawn that Astrophytum mirum Halda & Panarotto is a junior synonym of Astrophytum myriostigma subsp. tulense Kayser.
Annual Review of Phytopathology, Volume 60
Authors: Lipscomb Barney
Published: December 2022

The Annual Review of Phytopathology, in publication since 1963, covers significant developments in the field of plant pathology, including plant disease diagnosis, pathogens, host-pathogen interactions, epidemiology and ecology, breeding for resistance and plant disease management, and includes a special section on the development of concepts. Volume 60 (2022) has 17 papers.
Annual Review of Plant Biology, Volume 73
Authors: Lipscomb Barney
Published: December 2022

The Annual Review of Plant Biology, in publication since 1950, covers the significant developments in the field of plant biology, including biochemistry and biosynthesis, genetics, genomics and molecular biology, cell differentiation, tissue, organ and whole plant events, acclimation and adaptation, and methods and model organisms. Volume 73 has 27 papers.
Reviewers for Journal of the Botanical Research Institute of Texas, Volume 16, 2022
Authors: Lipscomb Barney
Published: December 2022

Reviewers for Volume 16 (2022) of Journal of the Botanical Research Institute of Texas. There are 55 reviewers for Volume 16.
Aureococcus anophagefferens population count, and relative size (Violet SSC) by flow cytometry (CytoFLEX S Flow Cytometer Beckman Coulter) v1
Authors: E. Chase Emily
Published: December 2022

A method for obtaining relative cell size, population density, etc., of the brown tide algae Aureococcous anophagefferens by a Violet Side Scatter configuration on a Beckman Coulter CytoFLEX S Flow Cytometry System (CytExpert software).
The Use of the Token Economy in ESL Classrooms During the COVID-19 Pandemic
Authors: Kasiveloo Mathura , Tan Kim Hua , Said Nur Ehsan Mohd , Philip Bromeley , Rashid Syar Meeze Mohd
Published: December 2022

The token economy is a pivotal notion in educational settings for maintaining good classroom behaviours among learners. Despite the burgeoning number of studies conducted to determine the efficiency of the token economy, most have been primarily interested in the learners’ perspective. With a gap in the literature to investigate the phenomenon from the educators’ perspectives, the present study surveyed 154 English teachers in Malaysia during the COVID-19 pandemic. The respondents who taught at government schools were involved in examining the token economy as an approach to behavioural management and learning engagement. The data collection was performed through a self-completed questionnaire survey of Google Form via various online platforms. The study showed that Malaysian English teachers from government schools were in complete agreement that the implementation of the token economy in ESL classrooms is effective in eliciting desired behaviours and reducing disruptive behaviours among learners. Social and physical reinforcement were the most effective forms of the token economy in the classroom as opposed to other types of reinforcement. The implications of the study include the possibility of the token economy becoming a catalyst in the educational landscape for changing behaviour and boosting learning motivation, particularly among young learners who are usually emotionally sensitive.
Advancing Motivation and Aptitude Research in Relation to Teachers' Practices and Successful L2 Learning Outcomes
Authors: Al-wossabi Sami Ali Nasr
Published: December 2022

The underlying constructs of aptitude and motivation in language learning have been a central topic in SLA research. However, issues investigated in this regard, have not substantially discussed the effect of teachers' practices on learners' motivation and language aptitude. This paper, therefore, argues that novel research is needed to examine the impact of teachers’ classroom practices on stimulating learners to engage effectively in learning and improving their ability to acquire and apply L2 knowledge. Towards this end, a detailed discussion of research findings of some influential SLA work on aptitude and motivation is carried out. The aim is to trace early and recent concepts of research findings on aptitude and motivation and interpret them in the light of their practical and pedagogical relevance to the achievement of L2 learning. Based on the research synthesis, practical implications are devised with the ambition to open a new avenue for future research to examine the effect of teachers' practices on learners' aptitude and motivation and whether such effect correlates positively with foreign/second language learning. The paper ends with classroom recommendations that are meant to keep students motivated and enable them to fully exhibit their language abilities with the hope of maximum attainment in the target language.
The Psychological State of the Poet and Its Relationship to Zahaafaat and Ilal: Abi Al-Shis Al-Khuza’i's Poem as a Model
Authors: Tawalbeh Ali M. Al
Published: December 2022

Due to the important role of meter with Zahaafaat and Ilal in expressing the feelings and thoughts of the poet which effects the poem as a document related to the writer’s soul, this study sought to investigate the relationship of the poet’s psychological state with meter, ryhyme, Zahaafaat and Ilal. The model of present study is the poem of Abu Al-Sheikh Al-Khuzaie to show the relation between these poetic elements from one side, and the psychological state of the poet from the other. To achieve the goal of the study, the researcher conducted a statistical analysis of, Zahaafaat, Ilal, Mutharik and Saakin for their validity – according to what the researcher believes - in finding a relationship or denies its existence.
Exploring Topics and Sentiment in the English Version of Yassawi’s Divan-i Hikmet: A Text Mining Approach
Authors: Suleimenova Zhazira Azamatovna , Abilkhamitkyzy Rysgul , Yskak Bakyt Amirkhankyzy , Korganbekov Bolat Saginbekuly
Published: December 2022

Sufism seems to be still vital for the world nowadays. Concerning Central Asia, Hodja Ahmed Yassawi may be deemed one of the earliest Sufi there, and his most famous work, which contributed to the Islamisation of the Turks, is a collection of wisdom called Diwan-i Hikmet. Therefore, this study attempts to evaluate the piece content using text mining techniques. The authors ran a term frequency analysis to uncover prevailing topical terms underlying the text along with their co-occurrence. Besides, the nature of emotion reflected in the writing was assessed based on the analysis of sentiment terms. The findings from the term frequency analysis show that the central concepts in the Diwan-i Hikmet are God, divine love, spiritual education, ascesis, and worship of God through service. Emotion-based data analysis revealed that the overall affective tone of the text has proven to be positive. The current work adds to the research on Sufi Islamic literature. The agenda for future research was specified.
Implications of Design Thinking in an EFL Classroom: Writing in Context
Authors: Nazim Mohd , Mohammad Taj
Published: December 2022

Writing has been considered as one of the most creative discrete skills teaching and English as a Foreign Language (EFL) practitioners always regard it as a challenge. Many scholars explored EFL students’ writing problems through qualitative and quantitative studies and offered suggestions and recommendations to address the issues. However, they reserved their conclusions with a revisit on the efficacy of the desired results. This research, in a one group pre/post quasi experimental research context, suggests design thinking’s five-step strategy: Empathize, Define, Ideate, Prototype, and Test, a relatively less experimented approach, to enhance EFL students’ writing performance with special emphasis on Capitalization, Punctuation, Spelling, Word-order, Tense, and Sentence-structure. The study sample consisted of 25 preparatory year students at Najran University who were taught paragraph writing using a five-step strategy based on the design thinking. The pre/post tests were conducted by the researchers to assess students’ writing performance before and after the experiment. Dependent samples t-test produced a significant difference in the results in favor of the post test. It is concluded that the design thinking’s five-step strategy had dramatically enhanced EFL student’ writing performance. Implications through further studies of design thinking are proposed to address other EFL teaching and learning issues.
Prevalence of multidrug-resistant Salmonella in raw shrimp and octopus in Campeche, Mexico
Authors: Tirado Torres David , Chan Keb Carlos Armando , Gutiérrez Alcántara Jocelyn , Pérez Balan Román Alberto , Baldemar Ake Canché , Vázquez Rodríguez Guadalupe , Perla Mayari Trejo Ramírez , Aragón Gastélum José Luis , Sarabia Alcocer Betti , Gutierrez Alcantara Eduardo Jahir
Published: December 2022

Introduction: Multidrug-resistant (MDR) pathogenic bacteria in seafood, especially shrimp and octopus, are significant public health concerns and are able to be transmitted to humans in foodstuffs, particularly when they are of animal origin. The present study was conducted to measure the antimicrobial susceptibility patterns and prevalence of Salmonella isolates obtained from octopus and shrimp in San Francisco de Campeche, Mexico.
Methods: Two hundred shrimp and octopus samples (one hundred each) were collected from the municipal market, and each sample consisted of 100 g. The present study used conventional methods to identify and isolate Salmonella, with the disk-diffusion method used to screen all isolates for sensitivity to 12 antibiotics.
Results: The prevalence of Salmonella was found to be 56% and 45% in shrimp and octopus, respectively. The high levels of Salmonella observed in the municipal market sampled by the present study reveal poor sanitary conditions in the processing and transport of the products of interest and those handling them at the point of sale. All the Salmonella strains were resistant to at least three antimicrobial classes. All shrimp isolates (100%) presented susceptibility to chloramphenicol and the majority (88%) presented sensitivity to ciprofloxacin, while the strains isolated in the octopus individuals sampled presented sensitivity to both the foregoing antibiotics (74% and 90%, respectively).
Conclusion: Based on the high prevalence in the samples analyzed, our results suggest that shrimp and octopus could be involved in Salmonella infections in the population.
FLEXIBLE PEDAGOGICAL RESPONSES TO HARD PROFESSIONAL CHALLENGES
Authors:   Russian State Vocational Pedagogical University, Kislov A.G. , Sumina T.G. ,   Russian State Vocational Pedagogical University, Feoktistov A.V. ,   Russian State Vocational Pedagogical University, Yuknevichus I.N. ,   Russian State Vocational Pedagogical University
Published: December 2022

The article considers the challenges for the national professional school, especially for the teachers in a new BANI world that is replacing the VUCA world. The most important feature of the BANI world is the incomprehensibility of what is happening and, most importantly, what is created by a person. One of the response options is to rely on the Lean-Agile methodology that allows one to reorganize the educational process adequately and optimally, to change the nature of interaction of all the participants and stakeholders and to update many traditional, including Russian, forms and values of work organization. The article justifies expediency of applying effective and promising principles of the Lean-Agile approach in conditions of Russian professional education
SPECIFIC FEATURES OF EDUCATIONAL ACTIVITIES IN VOCATIONAL EDUCATION INSTITUTIONS OF THE TAMBOV REGION
Authors:   Advanced Training Center, M. S. Solntsev College of Engineering and Technology of Ground Transport, Chuksin A.N.
Published: December 2022

The article presents the definition and the aim of educational work in modern secondary vocational education institutions. The analysis is carried out to determine whether the educational work meets the professional standard requirements. The article considers the characteristics of educational activity in the vocational education institutions of the Tambov region: emphasis on the formation of social and professional mobility of graduates; shift from education to self-education; compensation for the insufficient role of the family in the upbringing of the younger generation; teacher professionalism.
Case report of preoperative radiotherapy followed by surgery in patient with giant primary retroperitoneal G1 liposarcoma
Authors: Bart Yu.  I. , Glibichuk D.  A. , Abdulaeva R.  Sh. , Avdyukhin I.  G. , Kalinin А.  Е. , Chernykh M.  V.
Published: December 2022

Despite the development of contemporary surgical management of retroperitoneal liposarcomas, local recurrence remains the major challenge in the treatment of these tumors. Currently, surgery is the main treatment option for liposarcoma. The international cancer community faces a global goal — the development of new combined treatment options for the treatment of retroperitoneal liposarcoma to reduce the postoperative recurrence rate and increase the overall survival. This article presents the world literature data on the treatment of retroperitoneal liposarcomas and demonstrates a case report describing treatment of a patient with this disease in the N. N. Blokhin NMRC of Oncology.
¿Es el índice cerebroplacentario predictor de evento perinatal adverso en embarazos de bajo riesgo? Estimamos la prevalencia en un hospital de tercer nivel en Colombia
Authors: Figueroa González Judeska , Fortich Arrieta Andy , Gómez Bossa Mauricio , Gómez Barbosa Mónica , Fernández Mercado Robinson
Published: December 2022

Introducción: El ratio cerebroplacentario resulta de la división de índice de pulsatilidad de arteria umbilical y arteria cerebral media el cual se utiliza con mayor sensibilidad para descartar evento perinatal adverso en embarazos en los que se conoce comorbilidades, se intentan describir otros usos para esta herramienta debido a su fácil aplicación. Objetivos: Determinar la prevalencia de evento perinatal adverso en fetos mayores de 34 semanas con crecimiento acorde en embarazos de bajo riesgo e índice cerebro/placentario alterado en Barranquilla entre 2017 y 2019. Metodología: estudio de tipo descriptivo transversal con análisis exploratorio de factores asociados, se revisaron 6607 doppler de los cuales 25 tuvieron el índice cerebroplacentario alterado y que cumplieron los criterios de inclusión y exclusión. Resultados: El 84% de las embarazadas fueron menores de 26 años, no se presentaron casos de mortalidad perinatal en este grupo de paciente relacionado con el índice cerebro/placentario. Sólo el 12% de los recién nacidos fueron ingresados a la UCIN, y para el APGAR menor a 7 durante los primeros 5 minutos solo el 4% de los recién nacidos lo presentaron. Conclusiones: El Ratio cerebroplacentario (RCP) se ha convertido en una herramienta de evaluación para los fetos con mayor riesgo de trastornos del crecimiento. Una RCP baja se asocia con resultados neonatales y perinatales adversos como esta descrito en la literatura.
Hipertrofia ventricular izquierda diagnosticada con ecocardiograma transtorácico y su relación con los cambios electrocardiográficos
Authors: García Rusca Alexander , Jacquin Serna Olga , Saad Cure Carlos , Rojano Rada Jairo
Published: December 2022

Objetivo: Evaluar la hipertrofia ventricular izquierda diagnosticada con ecocardiograma transtorácico y su relación con los cambios electrocardiográficos. Métodos: Se realizó un estudio observacional analítico, en los pacientes atendidos por el servicio de cardiología en el Hospital General de Barranquilla MiRed IPS, durante octubre de 2020 a marzo de 2021. Resultados: De un total de 111 pacientes, el 63,1% (n=70) correspondieron al sexo femenino, la edad promedio fue de 64,1 ± 11,8; el 21.6 % (n=24) presentaban hipercolesterolemia, el 26.1% (n=29) realizaban caminatas 3h semanales, y el 44.1% (n=49) eran obesos. El 90,1% (n=100) recibían tratamiento, siendo el losartan el de mayor uso con un 52,3% (n=58), el 77.5% (n=86) cumplía con el tratamiento, y el 67,6% (n=75) mostro valores normales de creatinina   0-1,0 mg/dL. Se estableció una diferencia significativa entre las categorías de los patrones electrocardiográficos, el 39,0% (n=30) con hipertrofia ventricular izquierda presentaron una pobre progresión de la onda R en V3 (p< 0.000), y aquellos que no mostraron hipertrofia ventricular izquierda, tenían otros hallazgos electrocardiográficos 67,6% (n=67), (p< 0.000). Los pacientes con patrón de hipertrofia concéntrica correspondieron el 76,6% (n=59), (p< 0.000) aquellos con hipertrofia excéntrica tenían el registro electrocardiográfico con índice de Sokolow-Lyon 16,2% (n=18). Ninguno de los hallazgos electrocardiográficos fue lo suficientemente exacto en la estimación de la hipertrofia ventricular izquierda. Conclusión: Se reportan en este estudio baja sensibilidad en los índices electrocardiográficos para el diagnóstico de hipertrofia ventricular izquierda con una gran diferencia en su poder diagnostico respecto al ecocardiograma.
Educación para residentes en anestesiología durante la pandemia por COVID-19 y perspectivas a futuro
Authors: Navarro-Jaramillo Heidy , Balkenhol-Nehuman Marcos , Vargas-Moranth Rusvelt
Published: December 2022

La pandemia por COVID-19 trajo muchas consecuencias en la educación médica. A pesar de la necesidad de contar con mano de obra calificada en los distintos niveles de atención y que los anestesiólogos juegan un rol importante en el manejo de la vía aérea del paciente, se presentó la necesidad de emplear estrategias educativas como plan de choque frente a lo anterior, tales como: seminarios web, aprendizaje en línea, Podcasts, redes sociales y Simulación y realidad virtual. Estos cambios han contribuido a unir un mundo globalizado, desde el punto de vista académico y a plantear perspectivas a corto y mediano plazo.
El papel de la epigenética en la artritis reumatoide
Authors: Chimá Bustillo Silvana Margarita , Chacón Guerra Marco Antonio , Saavedra Ruiz Jorge Andrés , Núñez Ospino Alejandro Alberto
Published: December 2022

La artritis reumatoide (AR) es una enfermedad de carácter autoinmune, que suele asociarse a la presencia de autoanticuerpos; pese a décadas de estudio, su etiología aún no está clara. En la actualidad, la investigación en torno a la AR está muy influenciada por el campo de la epigenética, con lo cual se han podido establecer asociaciones prometedoras, pudiéndose señalar que las modificaciones epigenéticas juegan un papel importante en la patogenia de la AR. En este sentido, se hace necesario ampliar el conocimiento acerca de las estas modificaciones en la AR, considerando que pueden ofrecer un mayor entendimiento de la fisiopatología de la enfermedad influenciando positivamente en prevención, diagnóstico y nuevas dianas terapéuticas. Con el propósito de profundizar en las modificaciones epigenéticas de la AR se consultaron distintas fuentes bibliográficas de base científica, seleccionando los artículos más relevantes  y con amplia evidencia respecto al tema.
The Management of Covid-19 Infection in Pregnancy and Puerperium: From the World View to the Italian Reality
Authors: Ciarambino Tiziana , Crispino Pietro , Buono Pietro , Trana Ugo , Patrone Gaetano , Mastrolorenzo Erika , Para Ombretta , Camardo Valentina , Giordano Mauro
Published: December 2022

Coronavirus disease 2019 (Covid-19) is characterized by severe acute respiratory syndrome and is an emerging disease. Considering the changes in maternal physiological and immune function during pregnancy, pregnant women may be at increased risk of being infected with Covid-19 and developing more complicated clinical events. Vertical transmission of the Covid-19 virus is possible although to this day it is still considered a rare event. It is conceivable that most pregnant patients infected with the Covid-19 virus have mild or moderate flu symptoms. More serious symptoms, such as pneumonia, in fact, seem to be more common in the elderly population or in subjects suffering from chronic diseases. As a precaution, pregnant women are considered the most vulnerable and therefore isolation and limitation of contact are recommended. At the moment there are no data to indicate whether spontaneous delivery is preferable in case of coronavirus infection (suspected or confirmed) to a cesarean section. However, in case of breathing difficulties that require delivery as soon as possible, a cesarean section is recommended. There is no evidence that the virus can be transmitted through breast milk. Furthermore, breastfeeding is preferable and has numerous benefits for the newborn's immune system. Since pregnant people appear to have a high risk of becoming seriously ill if they have an infection, vaccination is particularly important. In addition, there is evidence that vaccinated people have a lower risk of baby problems, such as stillbirth.
Time Perspective and Quality of Life in Persons Living with HIV in the Brazilian Context
Authors: OLIVEIRA DENIZE , Cecilio Hellen , Apostolidis Themis , Costa Tadeu , Hipólito Rodrigo , Oliveira Daniela , Domingues Juliana , Stefaisk Renata , Machado Yndira , Gomes Antonio , Marques Sergio
Published: December 2022

Background: Time perspective can be an important variable for the understanding the quality of life of people living with HIV/AIDS. Aims: The objective was to examine the relation between quality of life and time perspective among persons living with HIV receiving care from public health services in Brazil. Methods: Data were collected at four public health services in Brazil. Hierarchical regression analyses were then performed for each of six quality of life domains. Results: The subscales associated with high quality of life in physical and level of independence domains were low past-negative and high future orientation; psychological and environmental domains were low past-negative, high past-positive and high future orientations; social relations domain were high past-positive and high future orientations; and spirituality, religion and personal beliefs domain was low past-negative orientation. Conclusion: The hypothesis that time constructs have implications for the experience of the disease and for evaluation of quality of life was proven determined by positive orientations like future and past-positive and past-negative orientation.
Case Report of Mesorectal Failure in the Treatment of Prostate Adenocarcinoma
Authors: Shen James , Roubil John , Ding Linda , Trifone Julie , Bradford Carla , Liu Fenghong , Fan Yankhua , Kuo I-Lin , Bunaciu Camelia , Larosa Salvatore , Yu Suhong , Khalifeh Abdulnasser , Saleeby Jonathan , Bushe Harry , Bishop-Jodoin Maryann , FitzGerald Thomas
Published: December 2022

Prostate cancer afflicts a substantial portion of the male population with increasing incidence each decade after the age of 40. Standard of care for localized disease at presentation includes prostatectomy and/or radiation therapy which can include management of pelvic lymph nodes. However, the selection of lymph nodes treated by radiotherapy remains variable among practitioners including individual practitioners in the same institution. We present a patient with prostate adenocarcinoma who underwent radical prostatectomy with adjuvant radiotherapy for lymph node involvement and developed mesorectal failure secondary to metastatic spread to untreated tissue.
Evaluation of Common Clinical and Hemodynamic Parameters to Pulmonary Capillary Wedge Pressures in Patients Undergoing Right Heart Catheterization
Authors: Hocking Kyle , Huston Jessica , Schmeckpeper Jeffery , Polcz Monica , Case Marisa , Breed Meghan , Vaughn Lexie , Wervey Dawson , Brophy Colleen , Lindenfeld JoAnn , Alvis Bret
Published: December 2022

Introduction: A cornerstone of heart failure assessment is the right heart catheterization and the pulmonary capillary wedge pressure measurement it can provide. Clinical and hemodynamic parameters such as weight and jugular venous distention are less invasive measures often used to diagnose, manage, and treat these patients. To date, there is little data looking at the association of these key parameters to measured pulmonary capillary wedge pressure (PCWP). This is a large, retrospective, secondary analysis of a right heart catheterization database comparing clinical and hemodynamic parameters against measured PCWP in heart failure patients. Methods: A total of 538 subjects were included in this secondary analysis. Spearman’s Rho analysis of each clinical and hemodynamic variable was used to compare their association to the documented PCWP. Variables analyzed included weight, body mass index (BMI), jugular venous distention (JVD), creatinine, edema grade, right atrial pressure (RAP), pulmonary artery systolic pressure (PASP), systemic vascular resistance, pulmonary vascular resistance, cardiac output (thermal and Fick), systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, oxygen saturation (SpO2), and pulmonary artery diastolic pressure (PADP). Results: Ten out of 17 selected parameters had a statistically significant association with measured PCWP values. PADP had the strongest association (0.73, p<0.0001), followed by RAP and PASP (0.69, p<0.0001 and 0.67, p<0.0001, respectively). Other significant parameters included weight (0.2, p<0.001), BMI (0.2, p<0.001), SpO2 (-0.17, p<0.0091), JVD (0.24, p<0.005) and edema grade (0.2, p<0.0001). Conclusion: This retrospective analysis clarifies the associations of commonly used clinical and hemodynamic parameters to the clinically used gold standard for volume assessment in heart failure patients, PCWP.
FDA Clinical Investigator Inspection List, who is Inspected and What are the Results for Countries Outside US?
Authors: Härdig Bjarne , Platonov Pyotr
Published: December 2022

Background: The purpose of this analysis was to revisit the open US Food and Drug Administration (FDA) inspection list results from clinical trials and show the possibilities of evaluating inspection results between different world regions and explore what aspects of clinical trial deficiencies are most often reported. Aims: The aim of this study was to evaluate inspection results from different regions of the world and the deficiencies most often reported. Methods: On October 10, 2021, the clinical Investigator Inspection List was download as an Excel spreadsheet (Microsoft, Seattle, USA) from the FDA homepage. Data were extracted and categorized as: Number of inspections in each region and country, number and % of actions found during the inspections, number and % of deficiencies found – in total and in the different regions and countries. No statistical comparison was made on the analysed data in the article. Results: The total number of inspections performed by the FDA outside the US between 1980 and October 2021 was 3,222. The number of voluntary actions varies in the same manner as the number of inspections. The number of “no actions indicated” increased after 1994, which may indicate that adding new and smaller countries to participate in clinical trials does not affect the quality of the clinical trials. The results shows that most common action registered by the FDA was “voluntary actions indicated (VAI)” (56.6%) followed by “no action indicated (NAI)” (38.6%), while “official action indicated (OAI)” were rare (4.1%). “VAI” and “NAI” were registered in all regions. "VAI” were indicated for topics related to documentation and reporting in 787 inspections (24.4%), protocol violation in 683 inspections (21.2%)), informed consent/institutional review board in 257 inspections (8.0%). The same type of deficiencies was noted for “OAI”; however, these were significantly rarer. Conclusion: The US Food and Drug Administration only monitors a small number of all clinical trials performed worldwide (1.3%). Despite the large difference in the number of FDA inspections performed in different regions worldwide, the structure of inspection findings is remarkably similar across the globe.
Tuberculosis and Cancer Gallbladder in Endemic Zones: Diagnostic and Surgical Dilemma for the Physicians
Authors: Gupta Ashish , Jindal Ashish
Published: December 2022

Tuberculosis is an infectious disease widely prevelant in the developing world. The resurgence of tuberculosis is on rise even in the developed world as the chemotherapy and steroid use is increasing. Indo gangetic belt is endemic for both the tuberculosis and gallbladder cancer. Gallbladder cancer although rare pathology carries a high rate of morbidity and mortality. Involvement of gallbladder in tubercular infection is rare. However, when involved there is a significant overlap of the clinical and radiological signs in both these patients. The treating physicians in these areas are always in therapeutic dilemma for the management of these patients. The other benign gallbladder pathologies mimicking the cancer further add on to the challenge in these patients. This article embarks upon the various challenges that a surgeon encounters in the management of these patients.
Development of a Solvability Map
Authors: Zeng Gengsheng
Published: December 2022

From time to time, it is necessary to determine whether there are sufficient measurements for the image reconstruction task especially when a non-standard scanning geometry is used. When the imaging system can be approximately modeled as a system of linear equations, the condition number of the system matrix indicates whether the entire system can be stably solved as a whole. When the system as a whole cannot be stably solved, the Moore-Penrose pseudo inverse matrix can be evaluated through the singular value decomposition (SVD) and then a generalized solution can be obtained. However, these methods are not practical because they require the computer memory to store the whole system matrix, which is often too large to store. Also, we do not know if the generalized solution is good enough for the application in mind. This paper proposes a practical image solvability map, which can be obtained for any practical image reconstruction algorithm. This image solvability map measures the reconstruction errors for each location using a large number of computer-simulated random phantoms. In other words, the map is generated by a Monte Carlo approach.
Intolerance of uncertainty in pediatric patients: A transdiagnostic pathway to multiple disorders
Authors: Friedberg Robert , Goodman Callie , Choate Ellison , Zelcer Hannah , Mendez Eunice , Movahedi Yasaman , Trafalis Sandra , Xie Isabella , Neelly Megan , Zucker Joee
Published: December 2022

The search for transdiagnostic pathways and processes to emotional disorders in youth is an emerging and compelling field. In this mini-review, intolerance of uncertainty is posed as a transdiagnostic pathway. The theoretical foundation of intolerance of uncertainty is discussed. Subtypes of intolerance of uncertainty are explained, a behavioral typology is reviewed, neuropsychological correlates are briefly discussed, and age differences are addressed. The role of the Coronavirus-19 pandemic as a critical incident is examined. Subsequently, the research supporting the association between intolerance of uncertainty and anxiety, obsessive-compulsive,, depression, autism, as well as eating disorders is reviewed. The findings are then integrated into a parsimonious theoretical synthesis. Limitations of the research are delineated and clinical implications are presented Key Words: Intolerance of uncertainty, transdiagnostic, anxiety, depression, autism, eating disorders
Wake-Up Call for Action: The Current Situation of Public, Global and One Health Education during Medical School in Times of Globalization and Increasing Health Threats: A review
Authors: Sapoutzis Nikolaos , Corazza Laura , Wijnen-Meijer Marjo
Published: December 2022

Public, Global, and One Health are individual approaches to health that partly influence each other and all are becoming increasingly important in medical education. ‘’Public Health’’ is an approach to protect and improve health of a population. Nevertheless, most health threats are transcended national boarders, so the “Global Health” approach is becoming increasingly relevant. The holistic approach "One Health" goes even further: in addition to human health, animal health and the environment must also be considered. All these approaches are influenced by globalization, the increasing immigration and the occurrence of pandemics. Accordingly, it is the responsibility of higher education institutes to integrate health approaches in their curriculum to train future physicians to meet the demands of their patients and the population. This review reflects the current situation of the mentioned approaches in medical education in different countries from which data are available. The research shows that there exists a wide range of Public Health programms, but they are rarely assessed and only a small number of degrees programes is offered for physicians. In contrast to this, Global Health activities during medical education are more reported, and the main providers for Global Health education are medical schools. The necessity to implement One Health topics in medical curriculum is seen by many organizations, but there are just a few publications about the implementation in medical education available. The main issue in educating health approaches is a missing standard; the dissent of competences, which are relevant to future practical use; the curriculums are oversaturated; and a lack of expertise to the topics. For the future there is a need to implement health approaches into the core curriculum of medical education. Therefore, it is a possibility to integrate the subjects into existing activities and to use didactic concepts, such as clinical rotation, problem-based learning, or case-based learning. In addition, interprofessional work and partnerships between medical and Public Health communities must be improved. Public, Global, and One Health education requires a structured and comprehensive curriculum that ensures adequate training of medical students in an increasingly globalized world and diversified patient population.
Is minimally invasive shelf acetabuloplasty in adults more reliable than periacetabular osteotomy? Long- term results
Authors: Chiron Philippe
Published: December 2022

This is a retrospective, single-operator study which hypothesised that shelf acetabuloplasty for acetabular dysplasia with a centre-edge angle of Wiberg between 0° and 15° and stage 1 or 2 osteoarthritis, has comparable results to periacetabular osteotomy with less severe complications. Patients and methods: 95 hips, mean follow-up of 12.8 years (4-26.4), 70.5% female (67/95), 29.5% male (28/95), mean age of 34.7 years (16-61 years). The surgical technique was minimally invasive, intermuscular between the posterior border of the tensor facia lata muscle and the anterior border of the gluteus medius muscle as described by Chiron in 2007. Survival curves were analysed using the Kaplan Meier method with the Log Rank test; Cox power test: 0.832. Results: Complications: 4 graft lyses (4.2%); 3 non-unions (3.1%); 56.8% (54/95) screw removal; no infection, no lateral femoral cutaneous nerve injury, all low-grade complications with no high-grade. Total hip replacements: 22.1% (21/95) of which 52.3% (11/21) were in the first 5 years. Age and gender had a significant impact on survival: under 30 years, 13.9% (6/43); over 30 years, 30% (15/50); under 25 years, 0% (0/13; mean follow-up 14.6 years; 9 -26); females, 26.8% (18/67), males, 10.7% (3/28). Survival: Overall (5 years: 90%, 10 years: 83,5%, 15 years: 77%); according to age: under 30 years (5 years: 95,3%, 10 years: 88,8%, 15 years: 84,3%), over 30 years (5 years: 84%, 10 years: 77,4%, 15 years: 69%), P-value 0.0004; according to gender: females (5 years: 86,3%, 10 years: 77,4%, 15 years: 68,9%), males (5 years: 96%, 10 years: 92,1%, 15 years: 92,1%), p-value: 0,0826; females over 30 years (5 years: 80,4%, 10 years: 75,1%, 15 years: 64,4%), females under 30 years (5 years: 91,6%, 10 years: 87,3%, 15 years: 80%), P-value: 0,1502 Survival rates were similar to those for peri acetabular arthroplasty, with no serious complications. Checking for any associated labral hip tears and arthroscopic treatment beforehand should improve the total hip replacement rate in the first 5 years. Ideal patients are young males and those at risk are females over 30 years of age, but with results that are still acceptable for group at risk which justify this minimally invasive procedure
The role pressures for SENCos as managers, leaders and advocates in the Covid-19 pandemic and implications for inclusive education
Authors: Done Elizabeth
Published: December 2022

This paper aims to provide a literature-based consideration of the role of the Special Needs Educational Coordinator (SENCo) in England during COVID-19 pandemic conditions of school lockdown and partial reopening for children classified as vulnerable. The review indicates that the pressures and tensions already experienced by SENCos (around time, workload, status, and their prescribed dichotomised managerial and strategic role) were intensified under pandemic conditions, risking inadequate or delayed provision for children and young people with special educational needs and disabilities. The review also considers research prompted by related concerns around the exclusion or marginalisation of this group of students, through legal and illegal practices, during and following national lockdown. It had been suggested that the risk of exclusion might increase at this time, thus highlighting the advocacy role of SENCos, and small-scale research did report a lack of involvement of SENCos in strategic crisis planning at school level. It is concluded that an advocacy role for students with special educational needs and disabilities who were at risk of becoming increasingly marginalised within school and wider communities during the COVID-19 pandemic should now be considered as central to the SENCos’ remit.
Pandemics, privacy, and adoption of technology: Perceptions of the use of digital tools and data sharing during COVID-19 from 10 Latin American countries
Authors: Goyeneche Laura , Boruchowicz Cynthia , Lopez Boo Florencia , Tejerina Luis , Roseth Benjamin , Nelson Jennifer
Published: December 2022

This study describes the perception, adoption, and acceptance factors involved in the deployment of digital technologies for public health in Latin America and considers the implications for future digital health interventions. We conducted a descriptive analysis using nationally representative data from a phone survey conducted in 2020 in 10 countries in Latin America. We found that early in the pandemic, in countries with existing applications, 74% of the population used a smartphone, 47% had knowledge of the government app to report symptoms, but only 2% reported using it. Those interviewed reported that they are willing to share their personal data during a pandemic (61%) 50 percentage points higher than in non-pandemic times, although understanding how their personal data was used by the government and private companies was extremely low. More than 70% reported that they would use an application to report symptoms and would use an app that accesses their location or that uses contact tracing technology to alert them about possible exposure. Also, at least half of the users agree with preventive measures against COVID-19 such as daily follow-up calls, tracking via GPS for quarantine enforcement, and daily visits. In all countries, adoption of digital technologies increases if individuals or their relatives report they are infected; it decreases when end-users do not trust the anonymity policies or are concerned about government surveillance. Yet, encouraging greater adoption of digital technologies strongly depends on who designed the technology. Results show that 73% of users would prefer an app designed by an international organization such as the WHO to an app designed by the local government (64%) or a telephone company (56%). The study concludes with a reflection on the promising results of digital technologies and discusses the importance of considering users perceptions, factors for acceptance, and trust when pursuing adoption of digital technologies.
Pensando como tóxica: breve manual para el fact-checking
Authors: Simbaña Paola
Published: December 2022

La desinformación es un engaño. ¿Cómo podemos evitar ser una víctima más? Los periodistas no podemos solos contra tanta desinformación, todo usuario digital debe hacer su parte. La clave está en someter cada post —antes de compartirlo— a la minuciosa mirada de quien busca cazar un infiel. En este texto reflexivo se comparten algunas estrategias para verificar la originalidad y la transparencia de una información que circula en internet y/o redes sociales. Aquí una guía para ser tóxicos en esa búsqueda y frenar la viralidad de la desinformación.