bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Kurjak Antenatal Neurodevelopmental Test Ready for Routine Clinical Application? Bucharest Consensus Statement
Authors: Predojevic Maja , Vladareanu Radu , Antsaklis Panos , Stanojevic Milan , Salihagic Kadic Aida
Published: November 2015

Background

While two-dimensional ultrasound (2D US) is used only for the assessment of fetal startles and general movements, introduction of Kurjak antenatal neurodevelopmental test (KANET) by four-dimensional ultrasound (4D US) enabled assessment of not only movements but also some signs used in postnatal neurological assessment like cranial sutures, head circumference and finger movements of the hand for the detection of neurological thumb (adducted thumb in the clenched feast). Overall impression on general movement called by Prechtl ‘Gestalt perception’ is also a part of KANET assessment. These parameters cannot be assessed by 2D US, and according to our opinion they are making the difference enabling more accurate and functionally more reliable assessment of the young and immature CNS.

After Osaka standardization of KANET has been published, many studies on fetal behavior from different centers using this method have been conducted and published. Although there is lack of long-term follow-up of children who were assessed by KANET as fetuses, some conclusions on the usage of KANET test in clinical practice can be made. There are still inconclusive results of prenatal neurological assessment using KANET test in fetuses with borderline scores, although it was revealed that negative predictive value of the test as well as inter-observer reliability were satisfactory and acceptable.

Conclusion

It can be concluded that KANET test can be used in everyday clinical practice for the follow-up of fetuses at neurological risk with the strong recommendation for strict and reliable multidisciplinary postnatal follow-up till the corrected age of at least 3 years and longer whenever appropriate. This will enable to make better correlation of prenatal KANET scores with postnatal neurodevelopmental outcomes.

How to cite this article

Stanojevic M, Antsaklis P, Kadic AS, Predojevic M, Vladareanu R, Vladareanu S, Neto RM. Is Kurjak Antenatal Neurodevelopmental Test Ready for Routine Clinical Application? Bucharest Consensus Statement. Donald School J Ultrasound Obstet Gynecol 2015;9(3):260-265.
Invasive Prenatal Diagnosis: Chorionic Villus Sampling
Authors: Antsaklis Panos , Antsaklis Aris , Sindos Michael , Malamas Fotodotis M
Published: November 2015

Chorionic villus sampling (CVS) is the method of choice for first trimester invasive prenatal diagnosis. In expert hands, it is nowadays considered as safe as amniocentesis and has the advantage of an earlier diagnosis. In this review, we describe the technique of the procedure, its indications and contraindications and the requirements concerning adequate training and optimum clinical practice. We also discuss issues concerning the safety of the procedure in singleton and multiple pregnancies, other complications and controversies, such as the association with limb reduction defects and pre-eclampsia, as well as diagnostic problems and dilemmas, such as maternal cell contamination and confined placental mosaicism. We also describe new and promising methods of non-invasive diagnosis, based on the isolation and analysis of fetal cells or cell-free fetal genetic material from the maternal circulation, that aim to replace the invasive methods of prenatal diagnosis in the future.

How to cite this article

Sindos M, Malamas FM, Antsaklis P, Antsaklis A. Invasive Prenatal Diagnosis: Chorionic Villus Sampling. Donald School J Ultrasound Obstet Gynecol 2015; 9(3):293-306.
Systematic Appraisal of Diagnosis and Management of Arrhythmias in the Fetus
Authors: Sen Cihat , Uzun Orhan , Goynumer Gokhan , Beattie Bryan
Published: November 2015

Fetal arrhythmias are one of the most feared clinical problems encountered during the pregnancy that require prompt recognition and effective management by a multidisciplinary team involving fetal medicine specialist, fetal cardiologist, midwife, radiologist, sonographer, neonatologist and the patient herself. This review is aimed at providing a concise guide to medical practitioners involved in the care of pregnant women and the fetus on the diagnosis and management of fetal arrhythmias, follow-up principles and delivery recommendations.

How to cite this article

Uzun O, Goynumer G, Sen C, Beattie B. Systematic Appraisal of Diagnosis and Management of Arrhythmias in the Fetus. Donald School J Ultrasound Obstet Gynecol 2015;9(3):314-326.
An Interesting Case of Undiagnosed Conjoined Twins
Authors: Shailaja Nageshu , Krishna Lingegowda , Bhat BS , Kirtan Krishna
Published: November 2015

A 20 years old primigravida who presented to us at 36 weeks 3 days gestation with labor pains. She was perceiving fetal movements well, booked and immunized at a private hospital in Hosur. On examination, she was 7 cm dilated, well effaced, breech at 0 station. She was taken up for emergency lower segment cesarean section (LSCS) in view of primi with breech and mother not willing for vaginal delivery. An alive term 3.5 kg female paraphagus dicephalus twins was extracted. Extraction was difficult. Apgar was 3 at 1 minute and 5 at 5 minutes. The babies died after 45 minute. External examination showed that the twins were conjoined from the level of thorax downward. The twins had two heads, two upper limbs and a shared thorax, abdomen, pelvis and a single female external genitalia and single pair of lower limbs with CTEV (dicephalus, dibrachius, dispinous, thoraco-omphalopagus twins).

How to cite this article

Kirtan K, Doopadapalli D, Shailaja N, Krishna L, Bhat BS. An Interesting Case of Undiagnosed Conjoined Twins. Donald School J Ultrasound Obstet Gynecol 2015;9(3):327-330.
Prevalence and Possible Risk Factors of Peri-implantitis: A Concept Review
Authors: Nicoli Lelis Gustavo , Junior Elcio Marcantonio , Zandim-Barcelos Daniela Leal
Published: November 2015

Aim

The purpose of this review is to estimate the prevalence of peri-implantitis, as well as to determine possible risk factors associated with its development in patients treated with oral implants.

Background

Although implant therapy has been identified as a successful and predictable treatment for partially and fully edentulous patients, complications and failures can occur. Periimplantitis is considered a biologic complication that results in bone loss around implants and may lead to implant treatment failure.

Results

A great variation has been observed in the literature regarding the prevalence of peri-implantitis according to the diagnostic criteria used to define peri-implantitis. The prevalence ranges from 4.7 to 43% at implant level, and from 8.9 to. ≥56% at patient level. Many risk factors that may lead to the establishment and progression of peri-implantitis have been suggested. There is strong evidence that presence and history of periodontitis are potential risk factors for peri-implantitis. Cigarette smoking has not yet been conclusively established as a risk factor for peri-implantitis, although extra care should be taken with dental implant in smokers. Other risk factors, such as diabetes, genetic traits, implant surface roughness and presence of keratinized mucosa still require further investigation.

Conclusion

Peri-implantitis is not an uncommon complication following implant therapy. A higher prevalence of peri-implantitis has been identified for patients with presence or history of periodontal disease and for smokers. Until now, a true risk factor for peri-implantitis has not been established. Supportive maintenance program is essential for the long-term success of treatments with oral implants.

Clinical significance

The knowledge of the real impact of peri-implantitis on the outcome of treatments with oral implants as well as the identification of risk factors associated to this inflammatory condition are essential for the development of supportive maintenance programs and the establishment of prevention protocols.

How to cite this article

Marcantonio C, Nicoli LG, Junior EM, Zandim-Barcelos DL. Prevalence and Possible Risk Factors of Peri-implantitis: A Concept Review. J Contemp Dent Pract 2015;16(9):750-757.
Surface Texture and Optical Properties of Self-Adhering Composite Materials after Toothbrush Abrasion
Authors: Malavasi Caroline Veiga , Macedo Elisa Maria , da Costa Souza Karoline , Rego Guilherme Ferreira , Schneider Luis Felipe Jochims , Cavalcante Larissa Maria
Published: November 2015

This study evaluated the surface texture and optical properties of two self-adhering composites and a nanofilled composite before and after toothbrush abrasion. Vertise Flow (Kerr), Fusio Liquid (Pentron Clinical) and Filtek Z350 XT (3M ESPE) composites were divided into 3 groups (n = 6). Disks of 12 mm diameter and 2 mm thick were made. All materials were light-cured with a LED light source for 40 seconds. Analyses of surface roughness, gloss retention and color stability were performed 24 hours after light curing and after 20,000 brushing cycles. Data were analyzed with analysis of variance (ANOVA) and Tukey's test (α = 5%).

Results

Tukey's test ascertained that toothbrush abrasion resulted in rougher and matte surfaces for all composites tested. Filtek Z350 presented better gloss retention after abrasion. On surface roughness evaluation, there was no statistical difference between Fusio Liquid Dentin and Filtek Z350 resins (p > 0.05). Vertise Flow resin showed better color stability (ΔE), than the other two materials.

Conclusion

Nanofilled material presented better gloss retention but it did not produce the best results in aspects related to surface roughness and color stability compared to self-adhering composites.

Clinical significance

A simulation of degradation process by using toothbrush abrasion produced a rougher and matte surface in all composites tested. The surface texture was not only related to filler's amount present in materials, but also with the organic matrix composition of them. The results suggested that the constant development of new materials, seeking for a technical simplification, seems an innovative attraction for dentist's clinical routine, even though larger studies are necessary to promote to everyone a better understanding and improvement of action and effectiveness of this new class of materials.

How to cite this article

Malavasi CV, Macedo EM, da Costa Souza K, Rego GF, Schneider LFJ, Cavalcante LM. Surface Texture and Optical Properties of Self-Adhering Composite Materials after Toothbrush Abrasion. J Contemp Dent Pract 2015;16(10):775-782.
Linking Moralisation and Class Identity: The Role of Ressentiment and Respectability in the Social Reaction to ‘Chavs’
Authors: Le Grand Elias
Published: November 2015

This paper aims to link two fields of research which have come to form separate lines of inquiry: the sociology of moralisation and studies on class identity. Expanding on recent papers by Young (2009 , 2011 ) and others, the paper argues that the concepts of ressentiment and respectability can be used to connect moralisation processes and the formation of class identities. This is explored through a case study of the social reaction in Britain to white working-class youths labelled ‘chavs’. It is demonstrated that chavs are constructed through moralising discourses and practices, which have some elements of a moral panic. Moreover, moralisation is performative in constructing class identities: chavs have been cast as a ‘non-respectable’ white working-class ‘folk devil’ against whom ‘respectable’ middle-class and working-class people distinguish and identify themselves as morally righteous. Moralising social reactions are here to an important extent triggered by feelings of ressentiment. This is a dialectical process where respectability and ressentiment are tied, not only to the social control of certain non-respectable working-class others, but also to the moral self-governance of the moralisers.
Regional climate signal vs. local noise: a two-dimensional view of water isotopes in Antarctic firn at Kohnen station, Dronning Maud Land
Authors: Münch T. , Kipfstuhl S. , Freitag J. , Meyer H. , Laepple T.
Published: November 2015

Abstract. In low-accumulation regions, the reliability of δ18O-derived temperature signals from ice cores within the Holocene is unclear, primarily due to small Holocene climate changes relative to the intrinsic noise of the isotopic signal. In order to learn about the representativity of single ice cores and to optimise future ice-core-based climate reconstructions, we studied the stable-water isotope composition of firn at Kohnen station, Dronning Maud Land, Antarctica. Analysing δ18O in two 50 m long snow trenches allowed us to create an unprecedented, two-dimensional image characterising the isotopic variations from the centimetre to the hundred-metre scale. Our results show a clear seasonal layering of the isotopic composition, consistent with the accumulation rate, as well as high lateral isotopic variability caused by local stratigraphic noise. Based on the horizontal and vertical structure of the isotopic variations, we derive a statistical model for the stratigraphic noise. Our model successfully explains the trench data and allows to determine an upper bound of the reliability of climate reconstructions from seasonal to inter-annual time scales, depending on the number and the spacing of the cores taken. Implications for our study region include that reliably detecting a warming trend (0.1 °C decade−1) in 50 years of data would require ∼10–50 replicate cores with a horizontal spacing of at least 10 m. More generally, our results suggest that in order to obtain high-resolution records of Holocene temperature change, fast measurements, thus allowing multiple cores, are more important than to minimise analytic uncertainty as the latter only plays a minor role in the total uncertainty.
Modelo de monitoramento ambiental sistemático para decisão em Políticas Públicas
Authors: Cardoso Filho Jair Cunha , Araújo Júnior Rogério Henrique de
Published: November 2015

Aborda a interdisciplinaridade existente entre a Ciência da Informação e as políticas públicas, e propõe a ferramenta do monitoramento ambiental como instrumento relevante para o aprimoramento do processo de avaliação da efetividade social de políticas e de programas sociais, aí incluído o Poder Legislativo, por meio da coleta, tratamento e disponibilização de informações que possibilitem identificar as mudanças ambientais e propor, de forma consistente, o aperfeiçoamento de políticas públicas que atendam às demandas dos cidadãos.
Origem do modelo FRBR
Authors: Pacheco Kátia Lúcia , Ortega Cristina Dotta
Published: November 2015

Objetivo.O artigo identifica a gênese dos estudos do modelo conceitual Functional Requirements for Bibliographic Records (FRBR), publicado em 1998, pela International Federation of Library Associations and Institutions (IFLA), com a proposta de desenvolver nova abordagem para o registro bibliográfico. Método. Recorreu-se à pesquisa bibliográfica para identificar publicações científicas sobre o conceito de modelo e de modelo conceitual para então, a partir de fontes de informação oficiais da IFLA, tratar da gênese do modelo conceitual FRBR, a fim de investigar a trajetória que antecede a publicação do modelo e identificar o debate intelectual em torno de sua elaboração. Resultado. Constatou-se que o modelo FRBR nasceu com fins eminentemente práticos, pois engendra um conjunto de expectativas em torno da redução de custos da catalogação, indicando um nível mínimo de elementos nos registros bibliográficos que atendam às necessidades dos usuários associadas com os vários tipos de materiais e contextos de uso. Conclusão. O acúmulo do conhecimento científico, somado à dimensão experiencial trazida e sustentada no modelo, altera os paradigmas da catalogação tradicional, embora o relatório final do modelo não apresente os fundamentos que o sustentam.
Símbolos axiales en la poesía de José Ángel Valente
Authors: Aguirre-Martínez Guillermo
Published: November 2015

La poesía de José Ángel Valente posee una inusual densidad simbólica favorecida por la doble aspiración de abarcar tanto el extremo más grávido y material de la creación del autor, como aquel otro más etéreo y espiritual. Como componentes esenciales de esta búsqueda, podemos observar diversas imágenes (árbol, mandorla, hombre, cruz, etc.) que actuarán a modo de ejes simbólicos de su obra, ejes en torno a los cuales gira su universo poético. El estudio de los diferentes símbolos axiales, así como de otra serie de imágenes entendidas como proyecciones de aquéllos (laberinto, sierpe o nube), constituye el propósito del presente trabajo, tarea en la que relacionaremos cuanto vayamos descifrando con el sentido último de la poesía de José Ángel Valente.
Petrus Hispanus O.P. Auctor Summularum (III) ¿”Petrus Alfonsi” o “Petrus Ferrandi”?
Authors: D’ Ors Ángel
Published: November 2015

Este artículo pretende ser complemento y continuación de mis anteriores trabajos sobre la figura de Petrus Hispanus O. P., Auctor Summularum. Comienzo presentando algunos nuevos documentos relacionados con las cuestiones ya examinadas en mis artículos de 1997 y 2001. A continuación, me ocupo de las cuestiones aplazadas en el artículo de 2001: los problemas relativos a la figura de “Petrus Ferrandi” y su posible relación con el “auctor Summularum”, así como los argumentos de Tugwell contra la hipótesis de la posible identidad de estas dos figuras, examinados ahora desde la perspectiva del autor de la Legenda prima. Tras analizar testimonios procedentes de muy diversos ámbitos, afirmo, por una parte, que la hipótesis de la identidad entre “Petrus Ferrandi” y “Petrus Hispanus” podría ser correcta y, por otra parte, que no hay argumentos concluyentes que obliguen a afirmar con seguridad que el autor de la Legenda prima es Pedro Ferrando. Aunque los análisis no permiten por el momento determinar si es “Petrus Alfonsi” o “Petrus Ferrandi” el “auctor Summularum”, los testimonios recogidos y las conexiones establecidas contribuirán, sin duda, a orientar futuras investigaciones en torno a la figura de “Petrus Hispanus”.
La fijación léxica en el "Corpus diacrónico del español del Reino de Granada (CORDEREGRA)"
Authors: Martos García Paula
Published: November 2015

El estudio de las combinaciones léxicas según su grado de fijación y su distinción en combinaciones libres, colocaciones y locuciones ha sido realizado desde la perspectiva sincrónica. Planteamos la posibilidad de aplicar las pautas para distinguir estos tipos de estructuras en materiales de tipo diacrónico. Concretamente, nos basamos en los documentos que componen el Corpus del Español del Reino de Granada (CORDEREGRA) para valorar los materiales de este corpus histórico-lingüístico y comprobar si los criterios sincrónicos se pueden aplicar al estudio de documentos de otros siglos.
Las comedias húngaras de Lope de Vega: una cadena de intertextualidad y reescritura
Authors: Sáez Adrián J.
Published: November 2015

Dentro del conjunto de comedias dedicadas a la historia de Hungría, Lope de Vega cuenta con tres comedias con numerosas similitudes: El príncipe melancólico, El cuerdo loco y La sortija del olvido. Este trabajo examina las relaciones de intertextualidad y reescritura en las tres obras, así como algunos aspectos del desarrollo de la comedia palatina lopesca.
Multiple solutions for p-Laplacian eigenproblem with nonlinear boundary conditions
Authors: Berrajaa Mohammed , Chakrone Omar , Diyer Fatiha , Diyer Okacha
Published: November 2015

In this paper we study the existence of at least two nontrivial solutions for the nonlinear problem p-Laplacian, with nonlinear boundary conditions. We establish that there exist at least two solutions, which are opposite signs. For this reason, we characterize the first eigenvalue of an intermediary eigenvalue problem by the minimization method. In fact, in some sense, we establish the non-resonance below the first eigenvalues of nonlinear Steklov-Robin.
Surfaces family with common smarandache asymptotic curve according to bishop frame in euclidean 3-space
Authors: Saffak Atalay Gulnur , Kasap Emin
Published: November 2015

In this paper, we analyzed the problem of constructing a family of surfaces from a given some special Smarandache curves in  Euclidean 3-space. Using the Bishop frame of the curve in Euclidean 3-space, we express the family of surfaces as a linear combination of the components of this frame, and derive the necessary and sufficient conditions for coefficients to satisfy both the asymptotic and isoparametric requirements. Finally, examples are given to show the family of surfaces with common Smarandache asymptotic curve.
Epithelial Downgrowth after Cataract Surgery: An Atypical Presentation with Scleral Thinning and Massive Seeding in Anterior Chamber
Authors: Scarpa Giuseppe , La Gloria Valerio Alvise , Urban Francesca , Laurino Licia
Published: November 2015

Purpose

To report an atypical presentation of epithelial downgrowth (ED) after clear cornea cataract extraction, characterized by mixed clinical expression of both cystic and diffuse form and massive epithelial debris seeding in anterior chamber, associated with scleral involvement.

Methods

In this case report, fine needle anterior chamber aspiration cytology was performed to identify pathologic tissue invading iris, cornea, and angular structures. The patient was treated with anterior chamber membrane surgical excision.

Results

Epithelial downgrowth was identified by cytologic assessment. The patient was treated with epithelial membrane peeling and scleral defect conjunctival covering. This conservative surgical approach led to a significant reduction of ocular pain. During follow-up, residual epithelial tissue was present in anterior chamber without tendency to regrowth.

Conclusions

In doubtful cases of ED, histocytopathologic analysis should be performed without hesitation. Avoiding more invasive procedures, early detection and prompt surgical approach can result in improved outcome even in case of extensive intraocular involvement.
Anterior Chamber Migration of Dexamethasone Intravitreal Implant (Ozurdex®) through Basal Iridectomy (Ando) in a Pseudophakic Patient
Authors: Stepanov Alexandr , Codenotti Marco , Ramoni Andrea , Prati Matteo , Jiraskova Nada , Rozsival Pavel , Bandello Francesco
Published: November 2015

Purpose

Intravitreal implantation of dexamethasone implant (Ozurdex®) is being widely used for the treatment of macular edema (ME) after branch or central retinal vein occlusion, diabetic ME, and persistent ME associated with uveitis or Irvine-Gass syndrome. We describe a complication: migration of the dexamethasone implant into the anterior chamber through basal iridectomy (Ando) in a pseudophakic patient with development of corneal edema and secondary high intraocular pressure.

Methods

This is a case report of migration of Ozurdex® through basal iridectomy in a pseudophakic patient with iris claw lens.

Conclusions

Pseudophakic patients, with a history of vitrectomy, even those with a basal iridectomy (Ando), are at high risk for migration of the Ozurdex® into the anterior chamber and development of corneal edema.
Ki-67 Labeling Index can be used as a Prognostic Marker in Gastrointestinal Stromal Tumor: A Systematic Review and Meta-Analysis
Authors: Pyo Jung-Soo , Kang Guhyun , Sohn Jin Hee
Published: November 2015

Purpose

The aim of this study was to investigate the prognostic relevance of the Ki-67 labeling index (LI) in gastrointestinal stromal tumor (GIST) through a systematic review, meta-analysis and diagnostic test accuracy review.

Method

The study included 1,967 GIST cases from 24 eligible studies. We investigated the correlation between high Ki-67 LI and survival and the proper criteria for high Ki-67 LI. In addition, a diagnostic test accuracy review was conducted to evaluate the predictive role of high Ki-67 LI for higher risk of tumor recurrence.

Results

A high Ki-67 LI was significantly correlated with worse disease-free survival (DFS) (hazard ratio [HR] 3.658, 95% confidence interval [CI] 2.687-4.979, p<0.001) and overall survival (OS) (HR 3.730, 95% CI 2.819-4.936, p<0.001). With regard to DFS and OS, the subgroup with a cutoff value of >4% for high Ki-67 LI had a higher HR than the subgroup with a ≤4% cutoff. In the diagnostic test accuracy review, a high Ki-67 LI was significantly correlated with higher risk of tumor recurrence (pooled sensitivity = 0.44, pooled specificity = 0.87, area under the curve on the summary receiver operating characteristic curve = 0.656).

Conclusions

Our results showed that a high Ki-67 LI was significantly correlated with worse prognosis and higher risk of tumor recurrence in GIST. Further prospective studies of the prognostic role of Ki-67 LI are necessary prior to application in clinical practice.
A Case of Financial Writing: Jay McInerney's Brightness Falls and the Hermeneutic of the New Economy
Authors: Neculai Catalina
Published: November 2015

Since the mid-1970s, New York City has been a hub for the rise to dominance and consolidation of the FIRE (finance, insurance, and real estate) industry. This transition from an older regime of industrial manufacturing to a new regime of finance, real estate, and risk-mediated transactions has resulted into new socio-spatial and cultural formations. New York fiction itself has tackled these changes, and an extraordinary exemplar of such literature is Jay McInerney's Brightness Falls (1992). The present article is the outcome of interdisciplinary “field work” that combines analyses of fictional, nonfictional, and critical writing, archival research, geographical, cultural, and political theories. More specifically, this fine-grained critique of the novel and its satellite writings deals with the emerging relationship between the arts and the new FIRE economy, manifest through relations of power in the market place, with consequences upon authorial and publishing practices, rhetoric, and the discourses of everyday life.
“Tres picheles y vaso” y “Aceite y trementina”
Authors: Martínez Julio
Published: November 2015

La simplicidad predominante en mis obras en tiempos pasados y actuales es el motivo que ha dominado cada momento de mi vida como pintor con sus matices particulares propios de cada momento. El contil, la herrumbre, los cartones frio cálidos y grisáceos, los picheles mostrando a flor de piel su larga vida en los fogones más sencillos y populares han cautivado mi atención por casi cuatro décadas.Julio MartínezArtista plástico nicaragüense
Cutis MarmorataTelangectásica Congénita
Authors: Rubi Rodas Perla Esmeralda , Caballero Castro Héctor Rubén
Published: November 2015

Acta Pediátrica Hondureña, Vol. 4, No. 2 / Octubre 2013 a Marzo 2014: 312
Principal Components Regression Estimation in Semiparametric Partially Linear Additive Models
Authors: Wei Chuanhua , Wang Xiaonan
Published: November 2015

Partially linear additive model is useful in statistical modelling as a multivariate nonparametric fitting technique. This paper considers statistical inference for the semiparametric model in the presence of multicollinearity. Based on the profile least-squares approach, we propose a novel principal components regression estimator for the parametric component, and provide the asymptotic bias and covariance matrix of the proposed estimator. Some simulations are conducted to examine the performance of our proposed estimators and the results are satisfactory.
Reviewer Acknowledgements for Journal of Politics and Law, Vol. 8, No. 4
Authors: Sheng Vivian
Published: November 2015

Reviewer acknowledgements for Journal of Politics and Law, Vol. 8, No. 4, 2015.
Stress Reduction in Chronic Patients’ Professional Carers Through Hydrotherapy
Authors: Vieira Carlos Eduardo , Fiamenghi-Jr Geraldo A. , Blascovi-Assis Silvana Maria , Bartholomeu Daniel , Montiel José Maria
Published: November 2015

Objetivo

Cuidadoras em trabalho institucional para pessoas com deficiências profundas exercem atividades fundamentais, mas desgastantes, observadas constantemente por todos os memberos da instituição (diretores, funcionários e até voluntários), provocando altos níveis de stress. O objetivo foi realizar uma atividade que reduza o stress em cuidadoras de pacientes crónicos institucionalizados.

Método

Participaram 11 cuidadoras formais de uma instituição residencial para atendimento de pessoas com paralisia cerebral severa, que responderam ao Inventário de Sintomas de Stress para Adultos de Lipp – ISSL, antes e após sessões de hidroterapia semanais.

Resultados

Os resultados demostraram que todas as participantes apresentaram elevado grau de stress antes das sessões e houve redução dos sintomas na maioria das participantes após a hidroterapia. São discutidas as necessidades destas profissionais com formação escolar básica, sem cursos técnicos e muito exigidas pelas instituições.

Conclusão

Quanto melhores forem as suas condições de trabalho, melhor será a sua relação com os assistidos, que são os motivos reais da existência das instituições.
8-Cl-cAMP, The Old Dog with New Tricks: A Review
Authors: Vladan Bajic  , Lada Živkovic  , Andrea Cabarkapa  , Biljana Spremo Potparevic
Published: November 2015

Current chemotherapeutic drugs act for the most part by killing cancer cells directly. Treatment with these drugs often can be harmful to normal cells and may cause incomplete elimination of the target cells, resulting in the recurrence of the disease. To coop with current treatments the path of biomodulation rather than cytotoxicity, has been seen in the role of cAMP in normal versus malignant cells. It has been found that an increase of cAMP levels in normal cells stimulates proliferation, and that in the same time cancerous cells are inhibited to proliferate. This inverted reaction has given the momentum for synthesis of various cAMP analogues and investigation of there antitumor activity. A number of analogues, such as 8-PIP-cAMP, 8-Br-CAMP or 8-HA-cAMP showed efficacy only in millimolar concentrations. Only one of them, 8-Cl-cAMP as specific analogue has achieved inhibition of proliferation and stimulation of apoptosis of malignant cells in low or micromole concentrations. Still, 25 years later the mechanism of action of 8-clcAMP has not been fully elucidated or defined. This review is to challenge these mechanisms of action and to set a view of the nature of 8-Cl-cAMP action.
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA
Authors: Lässig Charlotte , Matheisl Sarah , Sparrer Konstantin MJ , de Oliveira Mann Carina C , Moldt Manuela , Patel Jenish R , Goldeck Marion , Hartmann Gunther , García-Sastre Adolfo , Hornung Veit , Conzelmann Karl-Klaus , Beckmann Roland , Hopfner Karl-Peter
Published: November 2015

The cytosolic antiviral innate immune sensor RIG-I distinguishes 5′ tri- or diphosphate containing viral double-stranded (ds) RNA from self-RNA by an incompletely understood mechanism that involves ATP hydrolysis by RIG-I's RNA translocase domain. Recently discovered mutations in ATPase motifs can lead to the multi-system disorder Singleton-Merten Syndrome (SMS) and increased interferon levels, suggesting misregulated signaling by RIG-I. Here we report that SMS mutations phenocopy a mutation that allows ATP binding but prevents hydrolysis. ATPase deficient RIG-I constitutively signals through endogenous RNA and co-purifies with self-RNA even from virus infected cells. Biochemical studies and cryo-electron microscopy identify a 60S ribosomal expansion segment as a dominant self-RNA that is stably bound by ATPase deficient RIG-I. ATP hydrolysis displaces wild-type RIG-I from this self-RNA but not from 5' triphosphate dsRNA. Our results indicate that ATP-hydrolysis prevents recognition of self-RNA and suggest that SMS mutations lead to unintentional signaling through prolonged RNA binding.
Progressively Worsening Cyclic Rash: Diagnosis and Approach to Care
Authors: DeRosa Angela , Adams Shellee , Fee Erin Kathleen
Published: November 2015

Autoimmune progesterone dermatitis (AIPD) is an uncommon condition in which allergic dermatitis to endogenous progesterone manifests in cyclic cutaneous eruptions. In this case series, we present 3 patients with AIPD, each with unique presentations and medical histories emblematic of the disease. Cyclic dermatitis related to menses in a premenopausal woman should raise high clinical suspicion for AIPD, especially in the primary care or emergency setting. Because of the rarity of this disorder, this case series seeks to describe AIPD to medical providers of young women, as well as present relevant literature related to the disease. We propose clinical considerations for women of reproductive age with AIPD.
Fabrication and photoelectric properties of Er3+ and Yb3+ co-doped ZnO films
Authors: Feng Wei , Wang Xiangfu , Meng Lan , Yan Xiaohong
Published: November 2015

In this paper, the Er3+ and Yb3+ co-doped ZnO films deposited by a novel thermal decomposition method under different annealing temperature process have been reported. The effects of annealing temperature on the morphology and properties of the films are systematically studied. The resulting spectra demonstrate that the Er3+ and Yb3+ co-doped ZnO films possessed the property of up-conversion, converting IR light into visible light that can be absorbed by amorphous silicon solar cell. After all, inner photoelectric effect of the Er3+ and Yb3+ co-doped ZnO films in the amorphous as a light scattering layer are also found with an infrared 980 nm laser as excitation source.
Investigation of NH3 input partial pressure for N-polarity InGaN growth on GaN substrates by tri-halide vapor phase epitaxy
Authors: Hirasaki Takahide , Hasegawa Tomoyasu , Meguro Misaki , Thieu Quang Tu , Murakami Hisashi , Kumagai Yoshinao , Monemar Bo , Koukitu Akinori
Published: November 2015

The influence of NH3 input partial pressure on N-polarity InGaN grown by tri-halide vapor phase epitaxy was investigated. It was found that surface morphology, solid composition and optical properties were affected by NH3 input partial pressure. As shown in thermodynamic analyses, the indium content increased due to an increase in the driving force for InN deposition caused by increased NH3 input partial pressure. In addition, the deep level emission around 2.1 eV in photoluminescence measurements drastically decreased at higher NH3 input partial pressures. Ab initio calculations and subsequent secondary ion mass spectrometry measurements suggested the reduction of metal-vacancies and/or carbon impurity incorporation in the InGaN layers.
Adaptive divergence in resistance to herbivores inDatura stramonium
Authors: Castillo Guillermo , Valverde Pedro L. , Cruz Laura L. , Hernández-Cumplido Johnattan , Andraca-Gómez Guadalupe , Fornoni Juan , Sandoval-Castellanos Edson , Olmedo-Vicente Erika , Flores-Ortiz César M. , Núñez-Farfán Juan
Published: November 2015

Defensive traits exhibited by plants vary widely across populations. Heritable phenotypic differentiation is likely to be produced by genetic drift and spatially restricted gene flow between populations. However, spatially variable selection exerted by herbivores may also give rise to differences among populations. To explore to what extent these factors promote the among-population differentiation of plant resistance of 13 populations ofDatura stramonium, we compared the degree of phenotypic differentiation (PST) of leaf resistance traits (trichome density, atropine and scopolamine concentration) against neutral genetic differentiation (FST) at microsatellite loci. Results showed that phenotypic differentiation in defensive traits among-population is not consistent with divergence promoted by genetic drift and restricted gene flow alone. Phenotypic differentiation in scopolamine concentration was significantly higher thanFSTacross the range of trait heritability values. In contrast, genetic differentiation in trichome density was different fromFSTonly when heritability was very low. On the other hand, differentiation in atropine concentration differed from the neutral expectation when heritability was less than or equal to 0.3. In addition, we did not find a significant correlation between pair-wise neutral genetic distances and distances of phenotypic resistance traits. Our findings reinforce previous evidence that divergent natural selection exerted by herbivores has promoted the among-population phenotypic differentiation of defensive traits inD. stramonium.
Subduction system and flat slab beneath the Eastern Cordillera of Colombia
Authors: Chiarabba Claudio , De Gori Pasquale , Faccenna Claudio , Speranza Fabio , Seccia Danilo , Dionicio Viviana , Prieto Germán A.
Published: November 2015

Seismicity at the northern terminus of the Nazca subduction is diffused over a wide area containing the puzzling seismic feature known as the Bucaramanga nest. We relocate about 5000 earthquakes recorded by the Colombian national seismic network and produce the first 3‐D velocity model of the area to define the geometry of the lithosphere subducting below the Colombian Andes. We found lateral velocity heterogeneities and an abrupt offset of the Wadati‐Benioff zone at 5°N indicating that the Nazca plate is segmented by an E‐W slab tear, that separates a steeper Nazca segment to the south from a flat subduction to the north. The flat Nazca slab extends eastward for about 400 km, before dip increases to ∼50° beneath the Eastern Cordillera, where it yields the Bucaramanga nest. We explain this puzzling locus of intermediate‐depth seismicity located beneath the Eastern Cordillera of Colombia as due to a massive dehydration and eclogitization of a thickened oceanic crust. We relate the flat subducting geometry to the entrance at the trench at ca. 10 Ma of a thick ‐ buoyant oceanic crust, likely a volcanic ridge, producing a high coupling with the overriding plate. Sub‐horizontal plate subduction is consistent with the abrupt disappearance of volcanism in the Andes of South America at latitudes > 5°N.
Prediction of MeV electron fluxes throughout the outer radiation belt using multivariate autoregressive models
Authors: Sakaguchi Kaori , Nagatsuma Tsutomu , Reeves Geoffrey D. , Spence Harlan E.
Published: November 2015

The Van Allen radiation belts surrounding the Earth are filled with MeV‐energy electrons. This region poses ionizing radiation risks for spacecraft that operate within it, including those in geostationary orbit (GEO) and medium Earth orbit. To provide alerts of electron flux enhancements, 16 prediction models of the electron log‐flux variation throughout the equatorial outer radiation belt as a function of the McIlwain L parameter were developed using the multivariate autoregressive model and Kalman filter. Measurements of omnidirectional 2.3 MeV electron flux from the Van Allen Probes mission as well as >2 MeV electrons from the GOES 15 spacecraft were used as the predictors. Model explanatory parameters were selected from solar wind parameters, the electron log‐flux at GEO, and geomagnetic indices. For the innermost region of the outer radiation belt, the electron flux is best predicted by using the Dst index as the sole input parameter. For the central to outermost regions, at L ≧ 4.8 and L ≧ 5.6, the electron flux is predicted most accurately by including also the solar wind velocity and then the dynamic pressure, respectively. The Dst index is the best overall single parameter for predicting at 3 ≦ L ≦ 6, while for the GEO flux prediction, the KP index is better than Dst. A test calculation demonstrates that the model successfully predicts the timing and location of the flux maximum as much as 2 days in advance and that the electron flux decreases faster with time at higher L values, both model features consistent with the actually observed behavior.
New insights on the seismogenic potential of the Eastern Betic Shear Zone (SE Iberia): Quaternary activity and paleoseismicity of the SW segment of the Carrascoy Fault Zone
Authors: Martín‐Banda Raquel , García‐Mayordomo Julián , Insua‐Arévalo Juan M. , Salazar Ángel E. , Rodríguez‐Escudero Emilio , Álvarez‐Gómez Jose A. , Medialdea Alicia , Herrero María J.
Published: November 2015

The Carrascoy Fault (CAF) is one of the main active faults that form part of the Eastern Betic Shear Zone, a 450 km fault system that accommodates most of the convergence between the Eurasian (Iberia) and Nubian plates in the Betic Cordillera, south Spain. Although the CAF represents a major earthquake threat to the nearby City of Murcia, studies on its Quaternary tectonics and seismogenic potential are scarce to date. We present evidence that supports the division of the CAF into two overlapping segments with contrasting tectonic structure, Quaternary activity, and landform control: a SW segment, characterized by a broad fold‐and‐thrust zone similar to the forebergs defined in the Gobi‐Altai region, and a NE segment, characterized by a sharp mountain front controlled by strike‐slip tectonics. We attribute the differentiation into these two segments to the stresses associated with topography, which in turn is a consequence of the shortening component, at the middle Pleistocene, after circa 217.4 ka. For the SW segment we infer the occurrence of 9 to 11, Mw 6.7 paleoearthquakes in the last 30.2 kyr, and a slip rate of 0.37 ± 0.08 m/kyr. We date the occurrence of the last surface rupture event after 2750 B.P., and we estimate an average recurrence period of major events of 3.3 ± 0.7 kyr.
Copper‐Catalyzed Domino Synthesis of Benzo[4,5]imidazo[1,2‐a]pyrimidin‐4(10H)‐ones using Cyanamide as a Building Block
Authors: Lou Zhenbang , Wu Xudong , Yang Haijun , Zhu Changjin , Fu Hua
Published: November 2015

An efficient and practical copper‐catalyzed domino synthesis of benzo[4,5]imidazo[1,2‐a]pyrimidin‐4(10H)‐ones has been developed. The protocol uses N‐(2‐halophenyl)‐3‐alkylpropiolamides and cyanamide as the starting materials, inexpensive copper(I) iodide and pipecolinic acid as the catalyst and ligand, and the corresponding products were obtained in moderate to good yields.

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Growth Engineering of CH3NH3PbI3 Structures for High‐Efficiency Solar Cells
Authors: Dar M. Ibrahim , Abdi‐Jalebi Mojtaba , Arora Neha , Grätzel Michael , Nazeeruddin Mohammad Khaja
Published: November 2015

Controlling the growth of perovskite crystals has been one of the interesting strategies to mold their fundamental properties and exploit their potential in the fabrication of high performance solar cells. Herein, the impact of chloride on the conversion of lead halide into CH3NH3PbI3, morphology, and coverage of perovskite structures using modified two‐step approach is investigated systematically, which eventually dictates the overall performance of the resulting device. Structural and morphological characterization is thoroughly carried out by X‐ray diffraction and field emission scanning electron microscopy, respectively. Various spectroscopic techniques provide ample evidence that CH3NH3PbI3 structures formed in the presence of chloride, in the lead halide precursor solution, exhibit desired properties, such as fewer defects. Moreover, the morphology of CH3NH3PbI3 structures and surface coverage of the resulting layers are considerably different from those obtained in the absence of chloride. After gaining a rational understanding regarding the effect of chloride on the growth, morphology, and optical properties of CH3NH3PbI3 structures, fabrication of devices revealing a power conversion efficiency of over 16% under standard AM 1.5 G illumination is realized. The fundamental understanding and high efficiency reported here distinguishes our results, particularly where chloride based precursors are involved.
Co–Ni‐Based Nanotubes/Nanosheets as Efficient Water Splitting Electrocatalysts
Authors: Li Siwen , Wang Yongcheng , Peng Sijia , Zhang Lijuan , Al‐Enizi Abdullah M. , Zhang Hui , Sun Xuhui , Zheng Gengfeng
Published: November 2015

One promising approach to hydrogen energy utilization from full water splitting relies on the successful development of earth‐abundant, efficient, and stable electrocatalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Here, homologous Co–Ni‐based nanotube/nanosheet structures with tunable Co/Ni ratios, including hydroxides and nitrides, are grown on conductive substrates by a cation‐exchanging method to grow hydroxides, followed by anion exchanging to obtain corresponding nitrides. These hydroxide OER catalysts and nitride HER catalysts exhibit low overpotentials, small Tafel slopes, and high current densities, which are attributed to their large electrochemically reactive surface, 1D morphologies for charge conduction, and octahedral coordination states of metal ions for efficient catalytic activities. The homologous Co–Ni‐based nanotube hydroxides and nitrides suggest promising electrocatalysts for full water splitting with high efficiency, good stability, convenient fabrication, and low cost.
Social cognition as an RDoC domain
Authors: Gur Ruben C. , Gur Raquel E.
Published: November 2015

While the bulk of research into neural substrates of behavior and psychopathology has focused on cognitive, memory and executive functions, there has been a recent surge of interest in emotion processing and social cognition, manifested in designating Social Cognition as a major RDoC domain. We describe the origins of this field's influence on cognitive neuroscience and highlight the most salient findings leading to the characterization of the “social brain” and the establishments of parameters that quantify normative and aberrant behaviors. Such parameters of behavior and neurobiology are required for a potentially successful RDoC construct, especially if heritability is established, because of the need to link with genomic systems. We proceed to illustrate how a social cognition measure can be used within the RDoC framework by presenting a task of facial emotion identification. We show that performance is sensitive to normative individual differences related to age and sex and to deficits associated with schizophrenia and other psychotic disorders. Neuroimaging studies with this task demonstrate that it recruits limbic and frontal regulatory activation in healthy samples as well as abnormalities in psychiatric populations. Evidence for its heritability was documented in genomic family studies and in patients with the 22q11.2 deletion syndrome. Measures that meet such criteria can help build translational bridges between cellular molecular mechanisms and behavior that elucidate aberrations related to psychopathology. Such links will transcend current diagnostic classifications and ultimately lead to a mechanistically based diagnostic nomenclature. Establishing such bridges will provide the elements necessary for early detection and scientifically grounded intervention. © 2015 Wiley Periodicals, Inc.