bluuebunny/crossref_metadata_2025 huggingface dataset:
THE INFLUENCE OF N-METHYL-N′-NITRO-N-NITROSOGUANIDINE ON AVERMECTIN SYNTHESIS ABILITY OF STREPTOMYCES AVERMITILIS UKM AS-2179 AND APPEARING AUXOTROPHIC MUTANTS
Authors: Serhiychuk N. , Biliavska L. , Kolomiets Yu. , Zinchenko L. , Ilyuk N.
Published: June 2024

An important way to transition to ecologically safe agrotechnologies is the abandonment of chemical means of plant protection and the transition to biological ones. The effectiveness of the use of chemical means of plant protection is gradually decreasing, which is connected with the emergence of resistant populations of pests and pathogens. The aim of the presented work was to study the influence of N-methyl-N-nitro-N-nitrosoguanidine on the survival and isolation of highly active variants of S. avermitilis UKM As-2179, the avermectin-synthesizing activity of which would be higher than that of the original strain.

Biochemical methods of determining avermectin-synthesizing activity were used in the work, the qualitative assessment of the culture's ability to synthesize avermectins was performed by the TLC method, and the concentration of avermectins in ethanol extracts was determined by the colorimetric method. The influence of N-methyl-N-nitro-N-nitrosoguanidine on the viability and antibiotic activity of the avermectin complex producer S. avermitilis UKM As-2179 was studied. It was found that the optimal time for obtaining clones with increased antibiotic activity is 15 minutes of treatment with N-methyl-N-nitro-N-nitrosoguanidine, during which 30% of the spores of the studied strain survive, and the biosynthetic activity increases by 2.7 times. To identify clones of S. avermitilis UKM As-2179 with increased synthesis of natural avermectins, the method of induced МННГ mutagenesis can be used.
Can telephone data contribute to a national influenza surveillance system in Australia? A retrospective analysis
Authors: Hartley Mica , Biggs Janice , Glass Kathryn
Published: June 2024

Introduction:
 
Data collected from telephone helplines that provide health advice can improve the timeliness and accuracy of disease surveillance, contributing to an appropriate and rapid public health response.  We show how these data can forewarn health professionals of increased rates of influenza-like illness (ILI) in the community and discuss implications for COVID-19 syndromic surveillance.
 
Methods:
 
The healthdirect helpline (HH) captures demographic details and characteristics of symptoms from users in 6 Australian states and territories.  We compare ILI activity in the HH with ILI activity in emergency department (ED), laboratory, Flutracking and general practice (GP) data using cross-correlation functions. 
 
Results:
 
Helpline data correlated strongly with ED data (range in yearly correlations from 0.82-0.99), GP data (0.66 – 0.95) and Flutracking data (0.62-0.89), but yearly correlations with laboratory data varied (0.49-0.95).  The highest correlation with laboratory and GP data occurred when HH activity was 1-2 weeks in advance of these data, while correlations with ED and Flutracking data were strongest with no time lag.
 
Discussion:
 
Our analysis demonstrates that the number of ILI-related calls to the HH is a reliable indicator of ILI incidence in Australia.  An increase in calls is likely to occur simultaneously with an increase in visits to EDs and prior to an increase in positive laboratory influenza tests and visits to GPs.  A surveillance system including these data would assist health practitioners to receive timely and accurate estimates of the level of ILI in the community to better respond to and prepare for seasonal and epidemic influenza.
Polio program security in Pakistan and Afghanistan - finally legal but not safe.
Authors: Sutton Braidy , Muluneh Atalay Goshu , Kannan Anjali , Quigley Ashley
Published: June 2024

Both wildtype and vaccine-derived poliomyelitis has experienced a seemingly widespread resurgence in Pakistan and Afghanistan following the War in Afghanistan, the retreat and resurgence of the Taliban, population displacement, and the appropriation of a vaccine campaign to identify the whereabouts of Osama bin Laden. These systemic challenges have manifested in obscure ways by greatly increasing vaccine hesitancy amongst both populations, by exposing host-nation communities to vaccine-naive and disease-carriers in refugee populations, and on significant health security concerns for those working, volunteering, and adminstering vaccine campaigns. This watching brief ties these seemingly disparate threads together to provide an accurate snapshot of the challenges faced by Pakistan and Afghanistan.
Autonomia prawotwórcza niemuzułmańskich związków wyznaniowych jako dziedzictwo Imperium Osmańskiego na przykładzie Syrii i Egiptu
Authors: Adamczyk Andrzej
Published: June 2024

W niektórych państwach Bliskiego Wschodu, m.in. w Syrii i Egipcie, zachowane zostały rozwiązania prawne mające swoje źródło w systemie miletów Imperium Osmańskiego. Normy prawa wyznaniowego uznanych oficjalnie wspólnot niemuzułmańskich zostały usankcjonowane przez władze tych państw, co czyni systemy prawne tych państw pluralistycznymi. Celem publikacji jest wykazanie, w jakim zakresie zachowana została autonomia prawotwórcza niemuzułmańskich związków wyznaniowych w Egipcie i Syrii. W artykule przedstawiono: genezę miletów w tych państwach, zakres przedmiotowy i podmiotowy autonomii prawnej wspólnot niemuzułmańskich, źródła prawa uznane w Syrii i Egipcie oraz stosowane przez niemuzułmańskie wspólnoty wyznaniowe, a także niektóre problemy prawne wynikające z zachowania rozwiązań charakterystycznych dla Imperium Osmańskiego.
ISOLATION AND INHIBITION STUDY OF ERYVARIN D AND E FROM THE ROOT BARKS OF Erythrina variegata AGAINST RECEPTOR TYROSINE KINASES
Authors: D. Mujahidin  , I. Noviany  , E. Hermawati  , A. Danova  , L. Heliawati  , Y. M. Syah
Published: June 2024

Erythrina sp. contains alkaloids and flavonoids, which are the primary bioactive compounds found in these species. These organisms are a rich source of secondary metabolites. Two known pterocapans in this study, eryvarin D (1) and eryvarin E (2), were successfully isolated from the root bark extract of Erythrina variegata. The isolated compounds were elucidated using 1D- and 2D-NMR spectroscopy. Among the two compounds, only compound 2 was evaluated for its inhibitory activity against eight receptor tyrosine kinases (EGFR, HER2, HER4, IGFR, InsR, KDR, PDGFRα, and PDGFRβ). Compound 2 exhibited weak insulin receptor inhibitory activity. Thus, compound 2 could be a lead compound as an anticancer drug targeting insulin receptors for future development.
Specifics of Bilateral US-EU Relations under J. Biden Administration
Authors: Sharikov P. A
Published: June 2024

The article is dedicated to current state of affairs and perspectives of institutionalization of US-EU relations. Due to different international and domestic political reasons, after the 2020 the two sides declared a rapprochement. The US is likely to re-main the most influential center of power of the current system of international affairs. Due to the process of European integration, the EU acquired an ability to behave as an international actor and the US’ global partner. An ambitious bilateral agenda includes not only pragmatic goals, but a long-term intention to cooperate. Institutions of bilateral relations are supposed to build strategic partnership regardless of concrete political situation. The period from 2021 to 2023 were favorable for such efforts, because of the White House retreat from the isolationist foreign policy. The article explores different formats of cooperation between the US and the EU with special focus on high level co-operation. Interparliamentary connections between the US Congress and European Parliament play a special role in institutionalizing the relations. Special attention is paid to the new frameworks of executive branch cooperation, such as Council for Trade and Technology, as well as a number of Strategic Dialogues on different topics. Institutionalization of bilateral relations is aimed at consolidation of economic and technological resources for strategic confrontation against China.
Euroscepticism in the Russian-Speaking Community of Estonia: Modern Trends and Prospects
Authors: Tambi S. A
Published: June 2024

The attitude of Russian-speaking people living in the Republic of Estonia towards the processes of European integration has undergone some transformation since the restoration of Estonia’s independence in 1991 to the present day. A significant part of the representatives of national minorities in this state governed by Eurooptimistic political elites is attributed to a quite widespread Euroscepticism. This article is an attempt to analyze the features of Eurosceptic views among the modern large Russian-speaking community of Estonia, as well as to assess the extent of the spread of Eurosceptic ideas there. A typical portrait of a Eurosceptic Russian-speaking voter in Estonia is addressed, especially one who lives in areas of compact settlement of Russian speakers in this state. A circle of Eurosceptic parties in Estonia has been identified that have influenced the attitude of Russian-speaking residents of Estonia towards the EU. The content of the Eurosceptic beliefs of the Russian-speaking voter is revealed. The reasons for the traditional popularity of Eurosceptic ideas among the Russian- speaking population are determined, as well as the extent of anti-EU sentiment in the Russian-speaking community of Estonia. A number of factors have been identified that traditionally influence the sustainability of Euroscepticism in regions of Estonia with a significant Russian-speaking population. It is concluded that if in the 1990s an impressive part of the Russian-speaking residents experienced neutral or even Euro-optimistic sentiments ( largely due to their unfulfilled hopes for a qualitative improvement in their discriminatory situation after Estonia joined the EU), then while they gradually discovered that no radical transformations were expected (largely due to Brussels’ reluctance to put appropriate pressure on Tallinn), their generally pro-EU position transformed into Euroscepticism. The paper concludes that currently the Euroscepticism of the Russian-speaking population of Estonia is characterized by a trend towards a relative stabilization of the Eurosceptic sentiments of voters. The author using institutional and discursive methods makes a forecast on the future development of Eurosceptic sentiments among Russian-speaking residents in the medium term.
U.S. Energy Independence: Opportunities and Limitations
Authors: Khlopov O. A
Published: June 2024

Climate change, the shale revolution, which allowed the United States to become a key exporter in international oil and gas markets, along with the introduction of renewable energy sources to replace traditional energy resources, are new integral factors in U.S. energy policy and influence its changes. The introduction of new technologies in the energy sector has given the United States the opportunity to increase oil and gas production, reduce its dependence on imports of hydrocarbon resources, and increase their exports. D. Trump's energy policy aimed for global energy dominance of the United States by increasing oil and gas production and exporting hydrocarbon resources to the EU and other regions of the world. On the one hand, allows us to conclude about the energy independence of the United States. However, on the other hand, the analysis of the debate about U.S. energy independence shows two different approaches to understanding the concept. The first approach follows from the fact that a state is energy independent if its energy system produces more than enough energy for its needs. The second suggests that the state does not import any energy at all. The author concludes that, today, the United States has technological and financial advantages that allow it to influence the global energy market. However, in the near future, the United States will not be able to become an energy independent state – that is to abandon oil and gas, despite the use of renewable energy sources. The U.S. energy industry is closely interconnected with the rest of the world: some energy resources still come from external international markets, and America is deeply integrated into the global economy, where the price of hydrocarbon resources is set on the international market. In conditions of mutual dependence, trade links many countries together and no single oil supplier can easily ensure compliance with their own interests or dictate the terms of trade. Nevertheless, interdependence and mutual interests of all actors in the energy market are able to help strengthen the energy security of a state.
US Intangible Economic Cultural Capital (Outline for Characterization)
Authors: Studentsov V. B
Published: June 2024

Countries differ in their prevailing values, norms, traditions, perceptions, etc., what can be called intangible cultural capital. Since economic relations permeate all relationships between people, a special place in cultural capital is occupied by its economic dimension. The United States is, in every sense of the word, a unique country with a distinct economic cultural capital. Its specificity is determined by the fact that this community was formed as a result of multi-tribal and multilingual immigration, adopting the so-called American Creed as a dominant worldview, which is based mainly on the values of British Protestant settlers. With vast untapped natural resources and the complete absence of feudal relations, the newcomers had a wide scope of economic activity with an absolute equality of opportunities. Individualism, partly inherited from the English nuclear family, has risen to become the prevailing principle of their behavior. This individualism, voluntaristic in nature, did not preclude individuals from uniting freely in various social entities, while also allowing for easy separation. Americans placed emphasis in their economic activity on achievement, success, the measure of which was perceived to be wealth. The accumulation of wealth was not and is not condemned; it is believed that its source is primarily the hard work of its owners who perform important social functions (investment, development of new technologies, etc.). Meanwhile, the causes of poverty, both in the past and present, are often seen in the poor people's own misbehavior. One cannot rule out that the active influx of immigrants with different cultural capital may in the future provoke changes in the American Creed.
Indicators of Increased Military Production in the United States
Authors: Shkrobtak I. O
Published: June 2024

This study examines the indicators of increased activity within the United States military-industrial complex. It identifies key markers that reflect both the state of the military production industry and its potential reforms. The paper highlights the factors that signify the growth of industrial production in the American defense industry: social, demographic, economic, political, and personal. Separately, it explores the conditions under which the US military industry can become more prominent within the national economy.
Fakeization Processes in the U.S. Information Space: Problems and Solutions
Authors: Nerentz D. V
Published: June 2024

The modern world is facing an unprecedented growth of fake content, facilitated by several factors. First, social networks and messengers are becoming a key source of information for audiences. Second, the shift away from traditional media consumption leads to the inability to distinguish primary from secondary information. Third, artificial intelligence (AI) technologies make it possible to create extremely convincing fakes. Finally, the substitution of facts with opinions prevents people from obtaining objective assessment of situations. The mentioned reasons confirm the need for a scientific understanding of the current situation. The article considers approaches to the concept and typology of fake content, the influence of fakes on shaping the information landscape of the American world, post-truth as a phenomenon of modern reality, strategies to combat fakes at the audience, media and state levels.
The Institutionalization of English Language Hegemony in the United States of America
Authors: MARUSENKO M. A , Marusenko N. M
Published: June 2024

The article analyzes measures to institutionalize the hegemonic position of English in the United States. The desire of some states to give English an official status is explained by demographic and socio-economic problems: the growing share of African-American and Hispanic population, as well as economic problems of immigrant communities. General American, a standardized version of English, is proposed as a tool to improve the living standards of nonEnglish speakers and create a common American identity, which in the future should take over the functions of the national language.
Modal verbs as a means of expression in a literary text (based on the novel “Atemschaukel” (“The Swing of Breathing”)
by H. Müller).
Authors: Shipova I. A.
Published: June 2024

The article considers modal verbs in German as elements of the language
system, which can act in a literary text not only as actualizers of different
types of modality, but also as means of linguistic expressiveness. In the text
of H. Müller’s novel “The Swing of Breathing” (Herta Müller “Atemschaukel”),
we find the necessary prerequisites for the realization of the expressive
potential of modal verbs. The corpus of examples demonstrates that
the concentration of modal meanings in rather small parts of the text,
the contact arrangement of markers of non-deictic and deictic modality, their
combinatorial combination, the juxtaposition of the meanings of necessity,
possibility, desirability or undesirability intensify the expressiveness
of the content. With the help of the variable use of modal verbs, the author
figuratively represents the situation of violence and coercion, which constitute
the dominant meanings of the narrative.
Communicative strategies for gender
balance as an aspect of professional communicative competence of an English
language teacher
Authors: Shchedromirskaia A. I.
Published: June 2024

The article deals with the problem of the development of communicative
strategies for gender balance among trainee teachers. The article describes
the study conducted to estimate the level of development of communicative
strategies for gender balance of undergraduate and graduate students
in Linguistics. According to the study, the most difficult aspects
of the communicative strategies for gender balance are: the use of genderneutral lexical units, the ability to recognize gender stereotypes in the English
teachers’ speech, the use of gender-balanced forms of address and the ability
to define the problem of lack of knowledge in the field of gender balance
in English. The results of the study demonstrate that it is possible to integrate
tasks aimed at developing communicative strategies for gender balance into
the professional communicative training of English teachers.
Agreement with coordinated subjects containing a personal pronoun: Experimental data from Russian
Authors: Belova D. D. , Davidyuk T. I.
Published: June 2024

The article examines Russian predicative agreement with a coordinated subject containing personal pronouns. In cases when the conjuncts have different person features, the choice of person agreement is based on the person hierarchy; it is considered to be an almost universal mechanism. However, the corpus and experimental data presented in this article show that the person hierarchy is not strictly imposed in Russian. We consider the two types of coordinated subjects, mismatched in person: 1) я и Х ‘I and X’ / Х и я ‘X and I’, where X is a masculine proper name, and 2) я и ты ‘I and you’ / ты и я ‘you and me’. Six experiments were conducted using 1–7 Likert scale. The experiments presented sentences with different word order (SV(О) / (О)VS) and conjuncts (I and X / X and I / I and you / you and I). In addition, we included the predicate characteristics as separate factors in the experiments – temporal characteristics, unaccusativity/unergativity. In all experiments, 1st person plural agreement (for non-past tense) and plural agreement (for past tense) were rated most acceptable. Sentences with such agreement are also the most frequent in the collected corpus material. With (O)VS word order, first conjunct agreement also becomes possible. In non-past tense, 3rd person plural agreement is also acknowledged, even in experiments, in which none of the conjuncts bears the 3rd person feature. Examples with such agreement have also been found in the corpus. The acceptability level of possible agreement strategies depends on such factors as word order, conjuncts order, and agreement characteristics of the predicate
Against ATB-analysis of partial agreement
in Russian: An experimental study
Authors: Pasko L. I.
Published: June 2024

This paper presents the results of an experimental study addressing
predictions of the ATB-analysis of predicative partial number agreement
in Russian. In case of partial agreement in clauses with a coordinated subject,
the predicate shows singular agreement with only one of the conjuncts.
The alternative strategy, full agreement, involves plural agreement with
the entire coordinated subject. According to one of the approaches to partial
agreement, the ATB-analysis, partial agreement is impossible if the predicate
is symmetrical or linearly follows the subject. We conducted an experimental
study using acceptability judgement task (Likert scale 1–7), aiming to test
these statements. The experimental design included three independent
variables: 1. predicate type, 2. predicate position in relation to the subject,
and 3. predicate number. According to the results of the experiment,
the hypotheses of ATB-analysis were not confirmed: sentences with partial
agreement of symmetrical and non-symmetrical predicates were rated equally
acceptable; sentences with partial agreement in postposition were rated
significantly more acceptable than ungrammatical fillers, but less acceptable
than sentences with partial agreement in preposition. The results provide
an argument against the ATB-analysis.
Kemampuan Representasi Matematis Siswa antara yang Mendapatkan Pembelajaran Contextual Teaching and Learning dan Discovery Learning
Authors: Salma Firyal Anan , Sumartini Tina Sri
Published: June 2024

Beberapa alasan perlunya kemampuan representasi yaitu untuk membangun konsep dan berpikir matematis, serta untuk memiliki kemampuan pemahaman konsep baik yang dapat digunakan dalam pemecahan masalah. Penelitian ini merupakan penelitian kuasi eksperimen yang bertujuan untuk menganalisis perbedaan kemampuan representasi matematis antara siswa yang mendapatkan pembelajaran Contextual Teaching and Learning dan Discovery Learning. Populasi pada penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 2 Garut. Teknis pengambilan sampel menggunakan Purposive Sampling dengan sampel sebanyak dua kelas. Diperoleh kesimpulan bahwa terdapat perbedaan kemampuan representasi  matematis siswa antara yang mendapatkan model pembelajaran Contextual Teaching and Learning  dan model pembelajaran Discovery Learning, kualitas peningkatan kemampuan representasi  matematis siswa yang mendapatkan model pembelajaran Contextual Teaching and Learning dan Discovery Learning berinterpretasi sedang, dan sikap siswa terhadap model pembelajaran Contextual Teaching and Learning dan Discovery Learning berinterpretasi cukup.
Some of the reasons for the need for representational skills are to build concepts and think mathematically, as well as to have good conceptual understanding skills that can be used in problem-solving. This research is a quasi-experimental study that aims to analyze the differences in mathematical representation abilities between students who receive Contextual Teaching and Learning and Discovery Learning. The population in this study were all eighth-grade students of SMP Negeri 2 Garut. The sampling technique used was purposive sampling with a sample of two classes. It was concluded that there were differences in students' mathematical representation abilities between those who received the Contextual Teaching and Learning learning model and the Discovery Learning learning model, and the quality of improving the mathematical representation ability of students who received the Contextual Teaching and Learning and Discovery Learning learning models with moderate interpretation, and student's attitudes towards the learning model. Contextual Teaching and Learning and Discovery Learning have sufficient interpretation.
Towards a Distributed Continuum Computing Platform for Federated Learning Based Self-Adaptive IoT Applications
Authors: Abdennadher Nabil
Published: June 2024

The proliferation of sensing device technologies, and the growing demand for data intensive IoT applications, are paving the way to the next wave of transformation in IoT computing systems architecture. The goal today is to design, implement and deploy a seamless interconnection of IoT, edge and cloud resources in one computing system, to form a compute continuum, also referred to as edge-to-cloud. In this talk, compute continuum refers to the deployment and execution of self-adaptive machine learning-based applications employing IoT sensors. Because of their distributed nature over constrained resources devices, these applications leverage the cloud infrastructure for learning tasks while exploiting edge devices for inference tasks on data coming from local IoT sensors. But the next wave of development is already underway; it will involve designing edge-to-edge platforms where learning takes place locally. A coordination platform is used to exchange intelligence between the edges. This talk will be organised as follow: (1) why and what is continuum computing? (2) A comparative study of continuum computing solutions, (3) a cloud continuum platform deployed on edge-to-edge infrastructure and supporting distributed federated learning (FL) applications and (4) an example of a FL based IoT application, for smart grid and renewable energies, deployed on an open source distributed continuum computing solution. This talk is the result of two European projects: SWARM and LASAGNE.
Study of metallisation of titanomagnetite burnt pellets
Authors: Dmitriev A. N. , Pelevin A. E. , Vit'kina G. Yu. , Zlobin V. G. , Alektorov R. V. , Vyaznikova E. A. , Kataev V. V. , Marshuk L. A. , Smirnova V. G.
Published: June 2024

To efficiently process titanomagnetite deposits in the Urals, new technological solutions must be developed. One such solution is the production of metallized titanomagnetite pellets, followed by electric smelting. Modern electric smelting technologies have strict requirements for the materials used, including a metallization degree above 90%, high metallic iron content (>85%), low FeO content (<1%), and high compression strength. This article explores the potential for producing metallized pellets suitable for further processing into electric arc furnace smelting or for HBI production from enriched concentrates of Gusevogorsky and Pervouralsky deposits under laboratory conditions. The scheme for enriching the poor concentrate of Pervouralskydeposithas been developed. The study analyzed the chemical, phase, and mineralogical compositions of the obtained concentrates. The results showed that the total iron content after beneficiation was more than 65% for both deposits. The study concluded that titanomagnetite iron ore raw materials are suitable for the metallization process. The degree of metallization of burnt pellets, after reduction by gas of CO+N2 composition (90/10%) at exposure (240 min), reached 92% and higher.
Teeth Whitening: Optimization with Violet LEDs
Authors: Panhoca Vitor Hugo , de Souza Viviane Brocca , Ferreira Simone Aparecida , Bagnato Vanderlei Salvador , dos Santos Gabriela Dias Rosso , Nogueira Marcelo Saito
Published: June 2024

Introduction: Teeth whitening is an aesthetic treatment performed in dentistry, but it is also related to the individual's social life. Methods: This is a clinical case report of a patient with dental staining. The protocol shown is innovative due to the short application time of the whitening gel. The result was evaluated using the Vitapan Classic color scale. Results: The CBT patient was 58 years old, white and female, the initial measurement of the color of the right maxillary central incisor was performed with scale Vita Classic and presented a measurement of A2 and after tooth whitening with violet light combined with 35% hydrogen peroxide was evaluated with a final measurement of B1. Conclusion: We can consider the device containing violet LEDs combined with whitening gel to be effective for teeth whitening in this protocol, showing a reduction in clinical session time in the office and a reduction in painful sensitivity during and after clinical care.
Opportunities for utilizing hospital data to improve medical care quality and patient safety
Authors:   State Institution ", Skaletskyі Yu.M. ,   O.M. Marzіeiev Institute for Public Health of the NAMSU", Yavorovskyі O.P. ,   Bogomolets National Medical University, Kyiv, Ukraine, Brukhno R.P. ,   Bogomolets National Medical University, Kyiv, Ukraine, Rygan M.M. ,   Bogomolets National Medical University, Kyiv, Ukraine, Zinchenko T.O. ,   Bogomolets National Medical University, Kyiv, Ukraine, Ivanko O.V. ,   3KNP «Kyiv City Clinical Hospital №1 of the executive body of the Kyiv City Council (Kyiv City State Administration)», Kyiv, Ukraine
Published: June 2024

Objective. The purpose was to investigate the use of hospital data to enhance patient safety, while also considering hygiene and occupational safety concerns for medical staff. Materials and methods. In the course of the work, bibliosemantic, questionnaire-survey, hygienic and statistical research methods were used. Research results. The utilization of hospital data proves beneficial for improving the quality and safety of medical care and enhancing the efficiency of healthcare facilities. Despite the existing data collection system in healthcare, the national regulatory framework practically overlooks the issues of utilizing this data to enhance the performance of hospital institutions. A significant challenge in the effective use of medical statistics data is their generalized nature, which could be adressed through the implementation of an electronic healthcare system. A relatively detailed analysis of medical records of deceased patients only confirms the importance of developing organizational measures and recommendations that could improve the quality and safety of medical care not only within specific healthcare institutions but also within the healthcare system as a whole. Conclusions. Enhancing the regulatory framework regarding the utilization of medical statistics data is a pertinent task for domestic science and practice.
Retrospective analysis of the consumption of the main groups of food products by the population of Ukraine
Authors:   State Institution ", Petrenko O.D. ,   O.M. Marzіeiev Institute for Public Health of the NAMSU", Gulich M.P. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU"
Published: June 2024

The purpose of the article is to analyze trends in the nature of consumption by the population of Ukraine during 2000-2021 of food substances and energy, as well as the main groups of food products based on statistical indicators of the State Statistics Service of Ukraine. Materials and methods. The study included the analysis of information from national government statistics on population nutrition and its changes over a long period. The results. The nutrition structure of the population of Ukraine does not meet the requirements for rational nutrition. The analysis of the consumption of the main groups of food products since 2010 shows a gradual decrease in consumption and an unbalanced diet of the population. A decrease in the consumption of meat and meat products (less than recommended by 33.75%), milk and dairy products (less by 46.97%), fruits and vegetables (less by 34.44%), fish and fish products ( less by 34%). Low total caloric content of the diet and low estimated calcium content were also found. According to data on food consumption by the Ukrainian population compared to similar indicators in other countries, low consumption of meat and meat products, fish and vegetable oil, moderate consumption of sugar is noted. milk and milk products, significant consumption of vegetables and potatoes. Conclusions. The revealed trends in the structure of nutrition clearly indicate a significant impact of these changes on the life of the population, in particular, on the formation of health and an increase in the risk of developing food-dependent diseases. The nutritional status of Ukrainians requires careful attention and intervention to preserve and improve the health of the population.
Hol szab határt az etikus látásmód az emberi és természeti környezetben lezajló drónhadviselés harci momentumainak?
Authors: Major Gábor
Published: June 2024

Az emberiség történelmében új korszak köszöntött be a fegyveres konfliktusok terén. A hibrid hadviselés korát éljük. Abban a korban, ahol az ellenség nem hús-vér lényként velünk szemben állva üzen hadat, hanem valahol egy titkos, virtuális lövészárokból irányítja a mindent elpusztító fegyverkomplexumát a kiszemelt, leigázandó célra. Ebben a környezetben nehéz eldönteni, hogy mi valódi és mi nem, mi etikus és mi etikátlan, és nem csupán a távolról irányított harci eszközök által végzett cselekmények kusza világában, de a békésnek tűnő hétköznapok esetében is, a harcmezőktől távol. Ebben a publikációban a szerző célja, hogy definiálja a hadviselés egy új formáját, ami a kor technikai fejlődésének köszönhetően a légi gépi organizmusok csatájaként vonulhat be a köztudatba. Mindeközben az írás készítője ezt a harci cselekményt megpróbálja elhelyezni az etika, etikus viselkedés palettáján.
Primary production research in the Adriatic Sea
Authors: Matek Antonija , Ljubešić Zrinka
Published: June 2024

Primary production in the Adriatic Sea has been investigated for many years, however, a comprehensive systematic review of the literature is lacking. This paper aims to fill this gap by providing a thorough overview of all conducted studies, emphasising the methodologies employed, and comparing representative values. The first section introduces the history of primary production measurements and gives insights into the Adriatic basin’s hydrography and its impact on primary producers and their rates of production. The second section provides an overview of productivity across the geographical regions of the Adriatic Sea. The Middle Adriatic Sea stands out as one of the rare locations in the world where in situ measurements of primary production have been systematically conducted since the 1960s and are ongoing. This data has only recently been synthesised and corrected for overestimates using a modelling approach. The final section is an overview of all primary production studies supported with comprehensive summarising tables. Most of the data concerns phytoplanktonprimary production estimated by 14C method. Annual primary production in the Northern and Middle Adriatic ranges between 87.4–260.0 g C m-2 y-1, and 70.0–177.4 g C m-2 y-1, respectively. Southern Adriatic Sea is the least investigated, and only daily estimates are available (236–374 mg C m-2 d-1). The purpose of this review is to highlight the significance of measuring primary production in the Adriatic Sea and the need for future research that will contribute to a more comprehensive understanding of the basin’s productivity.
Peculiarities of speech ontogenesis of preschoolers with normotypical development and with combined developmental disorders
Authors:   Kamianets-Podilskyi National Ivan Ohienko University, Haletska Yuliya
Published: June 2024

In the article it is determined that from the variety of speech heard by the child, he chooses, assimilates and creates what he needs to solve the communicative tasks that appear before him in connection with the peculiarities of life at this stage of development. It is the development of communicative activity that determines the development of speech, and not vice versa. Thus, the speech of children of the same age, but different levels of communication development, differ significantly. The speech of children who are of different ages, but are at the same level of communicative activity, is approximately the same in terms of lexical composition, the complexity of grammatical design, and the length of sentences. This is explained by the fact that communicative tasks typical for a certain level of communication development determine selective perception and appropriation by children of various features of the speech they hear. According to typical communicative tasks, children with different forms of communication identify and assimilate various lexical and grammatical features in this language material. Therefore, for the development of a child's speech, it is not enough to offer him only a variety of language material, it is necessary to set new communication tasks for the child, which would require new speech means of communication. It was found that children with combined disorders have an underdevelopment of the meaningful side of speech and pronunciation of sounds, the lexical-grammatical composition of the language, and the dictionary. Such speech disorders arise as a result of profound visual disturbances caused by a visual analyzer disorder, and early speech underdevelopment is also observed.
Optimization of methods of cultivation of seed hemp with an ordinary method of sowing
Authors: Bakulova I. V. , Pluzhnikova I. I. , Kriushin N. V.
Published: June 2024

Relevance. The application of new techniques in the technology of cannabis cultivation is an important direction for the stabilization and growth of the efficiency of the hemp industry. The selection of the optimal seeding rate in combination with non-root treatment with an ordinary seeding method will solve the issue of realizing the productivity potential of a new variety of Lyudmila seeded hemp.

Methods. In order to optimize the cultivation methods of a new variety of cannabis Lyudmila, studies were conducted in accordance with the methodological guidelines for registration tests of fungicides in agriculture, methodological guidelines for production testing of research and development. The indicators of photosynthetic activity of plants in crops were determined by the method of A.A. Nichiporovich. The mathematical processing of experimental data was carried out by the method of dispersion analysis.

Results. Field germination was 66–75% of the laboratory, plant safety was higher at a seeding rate of 3 million/ha (220.4 pcs/m²). The leaf area was increased in variants with a seeding rate of 2.0 and 2.5 million/ha due to optimal plant placement. Non-root treatments with «Izagri Phosphorus» and «Humate+7» preparations increased the leaf area during all stages of ontogenesis. Non-root treatments and seeding rates affected the accumulation of total and long fiber – high yields of stems (11.9–15.9 t/ha) and fiber (3.43–5.04 t/ha) were obtained using the «Izagri Phosphorus» treatment option. The thickening of the stem increased the yield of the stems to 14.96 t/ha, and the yield of total fiber to 4.56 t/ha. The maximum seed yield (on average 1.0 t/ha) was obtained when sowing with a seeding rate of 2.0 million/ha, with the addition of non-root top dressing, the yield increased by 6.7–23.6%.
Theoretical studies of the movement of mineral fertilizer granules in the mixing chamber of a centrifugal mixing plant
Authors: Teterin V. S. , Panfеrov N. S. , Pehnov S. A. , Mitrofanov S. V.
Published: June 2024

Relevance. The use of mineral fertilizers helps to improve soil fertility, stimulates the growth and development of plants, which is achieved due to the availability of necessary nutrients. In turn, it is important to observe the correct application of fertilizers, which allows you to control the level of nutrients in the soil, preventing both their excess and deficiency. Currently, the main application of fertilizers falls on complex mineral fertilizers, while one of their disadvantages is that they may contain nutrients that will not be in demand by the plant, which can lead to a violation of the ecological balance. One of the solutions to this problem is the use of flour mixtures. When using mixtures, the determining factor is the uniformity of mixing, which is largely determined by the equipment used. In this regard, the urgent task is to develop a mixing equipment that meets the necessary indicators.

Methods. During the research, the processes occurring in the mixing chamber of the developed mixing plant were studied using methods of mathematical analysis, graphical and mathematical modeling.

Results. As a result of the research, it was found that during the operation of the mixing plant, the mixing quality is determined by the rotation frequency of the conical rotor. At the same time, the granules of mineral fertilizers after leaving the conical rotor, pouring into the collecting funnel, continue their movement along a spiral trajectory. During the movement of the granules along the surface of the rotating cone, as well as when moving through the funnel, their trajectories will intersect with each other, which will lead to their active mixing.
In vivo functional assessment of recombinant adeno-associated viruses carrying genes of protectively significant antigens of the African swine fever virus
Authors: Galeeva A. G. , Efimova M. A. , Frolov G. S. , Zubrinkin D. A. , Hisamutdinov A. G. , Garipov L. N. , Mingaleev D. N. , Ravilo R. Kh.
Published: June 2024

Relevance. African swine fever (ASF) is a viral hemorrhagic disease with exceptionally high mortality in members of the family Suidae, with serious economic consequences associated with production losses, trade restrictions and eradication programs. To date, no effective commercial vaccine against ASF has been developed. Of particular interest in the design of candidate vaccines are viral vectors, in particular the adenoassociated virus of the 2nd serotype (AAV2), which has successfully proven itself as a gene therapy agent. We previously reported the ability of rAAV2 to effectively deliver ASF virus genes B646L, E183L, CP530R, CP204L into porcine cells in vitro.

The aim of the study was to evaluate the in vivo functionality of adenoassociated viruses of the 2nd serotype carrying genes of protectively significant antigens of the African swine fever virus.

Methods. By cloning pairwise combined genes B646L-CP530R, E183L-CP204L into the pAAV-MCS vector, bicistronic constructs with the self-cleaving P2A peptide were created. Assembly of rAAV2 was accomplished by calcium phosphate transfection of AAV293 cells. After iodixanol density gradient purification, rAAV2 was administered to pigs at a dose of 3 × 1011 viral particles and humoral and cellular immunity was assessed for 180 days. The dynamics of antibody genesis were assessed by indirect ELISA, and immunophenotyping of peripheral blood T-lymphocytes was assessed by flow cytometry.

Results. It was found that the developed bicistronic constructs based on rAAV2 are safe and easily tolerated by animals and cause the induction of both humoral and cellular immune responses: the formation of virus-specific antibodies was observed, which persisted until the end of the experiment, as well as increased expression of CD8+ and CD4+ lymphocytes. The AAV platform we propose is a promising tool for creating a vaccine, however, a comprehensive characterization of rAAV2 can only be compiled after assessing its protective effect.
The efficiency of consumption and assimilation of nutrients of the diet feed, depending on the genotype and castration of young sheep
Authors: Kosilov V. I. , Yuldashbaev Yu. A. , Nikonova E. A. , Rakhimzhanova I. A. , Kalyakina R. G. , Sedykh T. A. , Dolgaya M. N.
Published: June 2024

Relevance. As a result of the scientific and economic experience, materials were obtained characterizing the peculiarities of consumption and assimilation of nutrients in the diet of sheep, depending on genotypic affiliation and castration.

Methodology. In order to perform the experiment, groups of experimental young animals were selected: I – Gypsy breed (sheep), II – ½ Tsigai × ½ edilbai (sheep), III – Tsigai breed (boulders), IV – ½ Tsigai × ½ edilbai (boulders).

Results. The effect of genotype and castration on the amount of consumed and digested nutrients has been established, which in turn affects their digestibility in the body and the formation of meat products. It is enough to note that crossbred rams and boulders having the genotype ½ Qigai × ½ edilbai surpassed purebred analogues in consumption of dry matter by 237.6 g (14.5%) and 227.5 g (8.15), organic matter – by 220.4 g (14.55%) and 200.0 g (14.2%), in digestion (assimilation) dry matter by 173.0 g (16.1%) and 167.8 g (16.8%), organic matter by 158.9 g (15.5%) and 152.5 g (16.2%). At the same time, both purebred and crossbred boulders were characterized by the lowest indicators.
Atypical Breast Reconstruction Case: Report of the Use of Rectus Abdominis Myocutaneous Flap for Deformity Treatment in Major Pectoral Flap Donor Area
Authors: Marchiori Julia Gabriela Oliveira , Pieri Bruno Guilherme Zampiri de , Silva Alfredo Benjamim Duarte da , Groth Anne Karoline
Published: June 2024

Introduction: Even with the advent of microsurgical techniques, the pedicled pectoralis major myocutaneous flap (MMF) still has considerable importance in head and neck reconstructions. However, its utilization is quite challenging especially in women. Case report: Female patient, 38 years-old sought medical attention due to a left cervical mass of progressive growth. After investigation with nuclear magnetic resonance imaging, radical cervical emptying was indicated, requiring immediate reconstruction with MMF. Subsequently, the patient returned complaining of asymmetry on the breasts and the volume of the cervical flap and a new surgical approach was performed by the plastic surgery team, where the left breast was reconstructed with a transverse rectus abdominis myocutaneous (TRAM) flap, and the MMF was thinned. Conclusion: The MMF should be used sparingly in women since resulting dysmorphisms often require surgicalre-administration for reconstruction. Therefore, it is preferable to use free flaps as a first option.