bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyse, Konzeptionierung und prototypische Implementierung einer Anwendung für Software-Monetarisierung im Intralogistiksoftwareumfeld der SYSKRON GmbH
Authors: Heigl Franziska , Herrmann Frank
Published: November 2023

Die vorgelegte Bachelor-Thesis befasste sich schwerpunktmäßig mit dem Thema Software-Monetarisierung. Die Frage nach der Umsetzung einer geeigneten Preisstrategie ist für Unternehmen ebenso von Bedeutung wie die Vertriebsart. Die größten Probleme, die hinsichtlich einer falsch gewählten Strategie auftraten waren beispielsweise der Verlust von Einnahmen sowie die unkontrollierte Vergabe von Lizenzen oder Berechtigungen, die der Kunde nicht bezahlen musste. Des Weiteren wurde eine Lizenzgenerierung von nicht befugten Mitarbeitern nicht unterbunden. Ein zusätzlicher Aspekt der im heutigen Zeitalter nicht unterschätzt werden darf, ist der Schutz der Software vor Diebstahl. Heutzutage werden Unternehmen von vielen Faktoren positiv gedrängt, z.B. wünschen sich viele Kunden flexiblere Lizenzmodelle. Dadurch sehen sich Unternehmen gezwungen, sich ausführlich mit dem relevanten Thema auseinanderzusetzen. Aus diesem Grund war das Ziel der Arbeit eine prototypische Anwendung für Software-Monetarisierung zu implementieren. Der Erreichung des Zieles ging die Entwicklung eines Konzeptes voraus. Dieses basiert auf vorherigen Analysen, in welcher geeignete Lizenzierungsmechanismen analysiert wurden. Die entstehende Anwendung soll es dem Unternehmen ermöglichen, seine aktuell vergebenen Lizenzen und Features kontrollieren, überwachen und verwalten zu können.
A deep learning approach for quantum dots sizing from wide-angle X-ray scattering data
Authors: Allara Lucia , Bertolotti Federica , Guagliardi Antonietta
Published: November 2023

Disclosing the full potential of functional nanomaterials requires the optimization of synthethic protocols and an effective size screening tool, aiming at efficiently triggering their size-dependent properties. Here we demonstrate the successful combination of a wide-angle X-ray total scattering approach with a deep learning classifier for directly sizing quantum dots in both colloidal and dry states. This work offers a compelling alternative to the lengthy process of deriving sizing curves from transmission electron microscopy coupled with spectroscopic measurements, especially in the ultra-small size regime, where traditional empirical functions exhibit larger discrepancies. The core of our algorithm is an all-convolutional neural network trained on Debye scattering equation X-ray simulations, incorporating atomistic models to capture structural and morphological features, and augmented with physics-informed perturbations to account for different predictable experimental conditions. The model performances are evaluated using both wide-angle X-ray total scattering simulations and experimental datasets collected on lead sulfide quantum dots, resulting in size classification accuracies surpassing 97%. With the developed deep learning size classifier, we overcome the need for calibration curves for quantum dots sizing and thanks to the unified modeling approach at the basis of the total scattering method implemented, we include simultaneously structural and microstructural aspects in the classification process, This algorithm can be complemented by incorporating input information from other experimental observations (e.g. small angle X-ray scattering data) and can be easily extended to other classes of nanocrystals, providing the nanoscience community with a powerful and broad tool to accelerate the development of novel functional (nano)materials.
Graph Neural Networks for Identifying Protein-Reactive Compounds
Authors: Cano Gil Victor Hugo , Rowley Christopher
Published: November 2023

The identification of protein-reactive electrophilic compounds is critical to the design of new covalent modifier drugs, screening for toxic compounds, and the exclusion of reactive compounds from high throughput screening. In this work, we employ traditional and graph machine learning algorithms to classify molecules being reactive towards proteins or nonreactive. For training data, we built a new dataset, ProteinReactiveDB, comprised primarily of covalent and noncovalent inhibitors from DrugBank, BindingDB, and CovalentInDB databases. To assess the transferability of the trained models, we created a custom set of covalent and noncovalent inhibitors, which was constructed from recent literature. Baseline models were developed using Morgan fingerprints as training inputs, but they performed poorly when applied to compounds outside the training set. We then trained various Graph Neural Networks (GNNs), with the best GNN model achieving an Area Under the Receiver Operator Characteristic (AUROC) curve of 0.84, precision of 0.92, and recall of 0.73. We also explore the interpretability of these GNNs using Gradient Activation Mapping (GradCAM), which shows regions of the molecules GNNs deem most relevant when making a prediction. These maps indicated that our trained models can identify electrophilic functional groups in a molecule and classify molecules as protein-reactive based on their presence.
Activation of anthraquinone’s electrophilicity by light for a dynamic C-O bond
Authors: Bykov Vasily , Ukhanev Stepan , Ushakov Igor , Vologzhanina Anna , Antsiferov Evgenii , Klimenko Lyubov , Lvov Andrey
Published: November 2023

Coupling of photoswitching with dynamic covalent chemistry enables the control of the formation and cleavage of covalent bonds by light irradiation. Peri-aryloxyanthraquinones feature an exclusive ability to switch electrophilicity by interconversion between para- and ana-quinone isomers, which was used for the first time for implementation of a dynamic C-O bond. Photogenerated ana-isomers undergo a concerted oxa-Michael addition of phenols to give hitherto unknown 4-hydroxy-10,10-diaryloxyanthracen-9-ones. These species were found to be in equilibrium with the corresponding ana-quinones, thus forming a dynamic covalent system of a new type. Withdrawal of the colored ana-quinones from the equilibria by visible-light irradiation resulted in two para-quinones with “locked” aryloxy groups.
Native mass spectrometry reveals binding interactions of SARS-CoV-2 PLpro with inhibitors and ISG15
Authors: James Virginia , Godula Rianna , Perez Jessica , Butalewicz Jamie , Sipe Sarah , Huibregtse Jon , Brodbelt Jennifer
Published: November 2023

Here we used native mass spectrometry (native MS) to probe a SARS-CoV protease, PLpro, which plays critical roles in coronavirus disease by affecting viral protein production and antagonizing host antiviral responses. Ultraviolet photodissociation (UVPD) and variable temperature electrospray ionization (vT ESI) were used to localize binding sites of PLpro inhibitors and revealed the stabilizing effects of inhibitors on protein tertiary structure. We compared PLpro from SARS-CoV-1 and SARS-CoV-2 in terms of inhibitor and ISG15 interactions to discern possible differences in protease function. A PLpro mutant lacking a single cysteine was used to localize inhibitor binding, and thermodynamic measurements revealed that inhibitor PR-619 stabilized the folded PLpro structure. These results will inform further development of PLpro as a therapeutic target against SARS-CoV-2 and other emerging coronaviruses.
FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response
Authors: Saxena Kritika , Roverato Nicola Domenico , Reithmann Melody , Mah Mei Min , Schregle Richard , Schmidtke Gunter , Silbern Ivan , Urlaub Henning , Aichem Annette
Published: November 2023

IFN-I secretion provides a rapid host defense against infection with RNA viruses. Within the host cell, viral RNA triggers the activation of the RIG-I signaling pathway, leading to the production of IFN-I. Because an exaggerated IFN-I response causes severe tissue damage, RIG-I signaling is tightly regulated. One of the factors that control the IFN-I response is the ubiquitin-like modifier FAT10, which is induced by TNF and IFNγ and targets covalently FAT10-linked proteins for proteasomal degradation. However, the mechanism of how FAT10 modulates IFN-I secretion remains to be fully elucidated. Here, we provide strong evidence that FAT10 is phosphorylated by IκB kinase β (IKKβ) upon TNF stimulation and during influenza A virus infection on several serine and threonine residues. FAT10 phosphorylation increases the binding of FAT10 to the TRAF3-deubiquitylase OTUB1 and its FAT10-mediated activation. Consequently, FAT10 phosphorylation results in a low ubiquitylation state of TRAF3, which is unable to maintain interferon regulatory factor 3 phosphorylation and downstream induction of IFN-I. Taken together, we reveal a mechanism of how phosphorylation of FAT10 limits the production of tissue-destructive IFN-I in inflammation.
Practical aspects of application of modern online platforms in professional training of future philologists of English
Authors: Konieva Marina , Koltunova Olena
Published: November 2023

The article raises the issue of using modern online platforms and digital technologies in the training of future English philologists. Theoretical analysis of modern research has shown the relevance of the integration of online learning tools in the educational process. As a center of potential educational resources, the Internet is a limitless environment for learning English, so its use is quite common. Modern online resources are educational platforms for learning, designed specifically for blended and distance learning of school and student youth and designed to provide students with video instructions, notes, tests and the ability to track their learning progress. The aim of the article is to identify practical aspects of the use of modern online platforms in the training of future English philologists. The object of research is the process of professional training of future English philologists. The subject of the study is online platforms as a didactic environment for students. In the process of professional activity, the online platform for learning English MyEnglishLab is expedient to use. The interactive platform provides an opportunity to communicate with students in real time, monitor the progress of individual students and the group as a whole, receive reports of completed tasks online. Another online learning resource is online courses. Such specialized courses are «Very Verified», «Business English», Coursera, Moodle. We see prospects for further research in the theoretical research and practical use of information and communication technologies with students in English language classes, finding new ways to improve speaking skills, communication, communication of future philologists, research and application of distance and blended learning of English.
A corpus analysis of the representation of war in Ukraine in the international press
Authors: Lőrincz Marianna
Published: November 2023

This paper explored the representation of war in Ukraine, utilizing corpus linguistics methods. It presents the gleanings of the analysis of the international press release covering the period February 24th - November 1st, based on a specialized corpus (1 081 971 tokens) of world newspaper articles compiled for this study. Using the LancsBox software package, a keyword analysis was carried out, providing a window into lexical patterns and typical themes associated with the war in Ukraine. The study highlighted the quantitative characteristics of the target corpus by singling out keywords and their collocates, followed by a qualitative interpretation of their usage in context. The themes commonly referenced in the target corpus were as follows: military intervention, actors/agents, implements, consequences, victims, description and attitudes, resistance, and economy. On the paradigmatic level, the highest occurrences were documented for lexemes war, invasion, and conflict as referents to the concept of ongoing warfare. On the syntagmatic level, lexically rich were the themes of attitudes towards war and its influence on the global economy. Negative discourse prosodies were evident in the discussion of war and some of its agents. In sum, the paper helps understand public attitudes and evaluation of war in the news coverage, which shape the image of Ukraine in the global arena.
Physiotherapist perceptions on rehabilitation services digitalization
Authors:   Transilvania University of Brașov, Pojala Ciprian Vasile , Bârsan Ionela Maria ,   Transilvania University of Brașov
Published: November 2023

Digital health solutions have experienced an essential expansion during the COVID-19 pandemic. Digitization contributes to ensuring the continuity of care for people and offers the possibility of more accessible access to information related to the patient, facilitates communication and can be a way to provide medical services through telemedicine. This work aims to identify the potential of the digitization of physiotherapy services. 17 physiotherapists from Romania completed a questionnaire with ten items. The results showed that although physiotherapists consider themselves prepared for computer systems, their use in medical practice mainly relates to communication with colleagues and other medical specialties.
СТРУКТУРА И СТАБИЛЬНОСТЬ НАНОКЛАСТЕРОВ ФОСФОРА В ШИРОКОМ ДИАПАЗОНЕ СОСТАВОВ (P17 - P220)
Authors: Рыбковский Д.В. , Лепешкин С.В. , Михайлова А.А. , Батурин В.С.
Published: November 2023

В работе проведено теоретическое исследование структуры и стабильности кластеров фосфора с числом атомов от 17 до 220. Для вычисления полных энергий кластеров была использована модель, позволяющая с высокой точностью воспроизводить результаты теории функционала плотности. Проведенные расчеты показали, что наиболее энергетически выгодными кластерами Pn с 17 ≤ n ≤ 90 являются одноцепочечные структуры. При 91 ≤ n ≤ 125 такие системы конкурируют с двойными цепочками волокнистого фосфора, а при n ≥ 126 кластеры волокнистого фосфора становятся более выгодными. Применение критериев локальной стабильности позволило выявить наиболее устойчивые кластеры, которые с большей вероятностью могут встречаться в эксперименте.
Digestibility of nutrients in the calves' diet depending on the level of selenium and cobalt asparaginate nanoparticles
Authors: Kalyuzhny Ivan Isaevich , Moskalenko Sergey Petrovich , Salautin Vladimir Vasilievich , Loshchinin Sergey Olegovich , Kuznetsov Maxim Yurievich
Published: November 2023

Due to the uneven distribution of minerals in the soil, the territory of the Russian Federation is divided into biogeochemical provinces. The Saratov region is deficient in cobalt, selenium is at the lower limit of the norm. The article examines the influence of a mineral feed additive consisting of nanoparticles of selenium and cobalt aspartate (OMEK-Co) on the digestibility of proteins, fats, and carbohydrates by calves when drinking milk. The authors established a reliable and positive effect of the studied feed additive on the digestibility and assimilability of nutrients. The increase in digestibility coefficients in calves of the experimental groups is associated with the intake of selenium and cobalt in the body in quantities that provide the required level for growth and development, since all other factors of feeding and housing conditions were the same.
Features of the biochemical composition of blood in calves with different dynamics of live weight gain
Authors: Nikolaev Semyon Viktorovich
Published: November 2023

The biochemical markers of blood associated with the rate of body weight gain were studied in the work. For experimental work, 30 calves on the 1st and 14th day after birth received venous blood and conducted laboratory tests. At the time of birth, as well as after 6 months of cultivation, the live weight of young an-imals was determined and the average daily increase was calculated. It was found that on the first day after birth in intensively growing animals, the activity of AlAT was lower by 56.6% (P?0.01), and AsAT by 45.4% (P?0.05), in relation to the indicators of young animals with a low rate of weight gain. Similarly, calves with intensive growth had a higher concentration of VSNMM in plasma by 30.4...48.4% (P?0.001) and 37.1...48.6% (P?0.01) in blood. On day 14, the biochemical profile of calves with low growth rates was characterized by a higher activity of alkaline phosphatase (by 27.4...46.6%; P<0.05), whereas in intensively growing young calves a higher level of calcium was observed (by 5.9%; P<0.05). The analysis of correlations showed that on the first day after birth, there was a pronounced relationship between the growth rate in relation to the activity of AsAT (-0.510) and AlAT (-0.497), iron concentration (-0.650) and VSNMM in blood plasma (0.626). Subsequently, the connection of these markers weakened, and the growth rate of calves was more dependent on the activity of alkaline phosphatase. So on the 14th day of postnatal ontogenesis, the correlation between the increase in live weight and enzyme activity was -0.744. Thus, it can be concluded that the activity of alkaline phosphatase is the most promising biochemical marker associated with the dynamics of body weight gain.
Development of a system for testing electronic control units of agricultural machinery
Authors: Nazarenko Dmitry Vladmirovich , Bolshev Vadim Evgenievich , Mosyakov Maxim Aleksandrovich , Kinev Nikolay Georgievich , Ivliev Evgeny Andreevich , Medvedev Denis Dmitrievich , Pasechnikov Andrey Romanovich , Nikolaev Konstantin Andreevich
Published: November 2023

Modern agricultural vehicles contain a large number of components, which include microcontrollers that implement various algorithms, so deviations and inaccuracies in their work naturally lead to failures and errors in the system as a whole. At the moment, manufacturers of agricultural machinery have in their arsenal relatively simple systems and testing methods that do not allow for a deep check of algorithms and their electronic components, so the development of a comprehensive system for testing electronic components is an urgent task. The article describes the development and operation of a testing system for setting up, testing and debugging the logic of the operation of existing and future (under development) electronic units, including control units from the on-board control system of agricultural machinery. In the process of work, methods of computer modeling, programming and software packages FreeCAD, CAD KOMPAS-3D v21 and SW4STM32 were used. The programming languages Python 3 and C/C++ were used to write the code. The result of the study is the development of a methodology and the manufacture of a prototype testing system (software and hardware complex), the practical use of which has shown its versatility and versatility. The developed system makes it possible to implement an analysis of the response of the control system to pre-designed test effects, to diagnose defects, breakdowns and malfunctions of the device, both in normal and emergency operating conditions. The system also allows you to simulate the emergency conditions of agricultural machinery and check the stability of the control device in limiting and emergency modes.
The influence of various tillage technologies on soil fertility, weed infestation and crop productivity in crop rotation
Authors: Svirina Vera Alekseevna , Chernogaev Vitaly Gennadievich
Published: November 2023

As a result of research for the third rotation of crop rotation (2008-2015), conducted on the basis of the ISA - a branch of the Federal State Budgetary Scientific Institution FNAC VIM in the conditions of the Ryazan region, the influence of various tillage technologies on the fertility of podzolized chernozem, weediness of crops and productivity of crop rotation crops was established. The smallest number of weeds was observed in the variants with combined treatments - up to 11.2-12.9 pcs/m? against the background of the use of herbicides and 21.3-19.6 pcs/m? against the unprotected background, which is lower compared to the control by 19.4-7.2 % in variants with protection and by 28.3-34.0 % in variants without protection. Also in these variants, a decrease in the wet weight of weeds was observed - by 13.5-15.2 % against the background with herbicides, respectively, while against the background without protection, an increase in wet weight was observed by 21.6-11.8 %, respectively. With flat-cut tillage, an increase in weed infestation to 16.2 pcs/m? with herbicides and 37.9 pcs/m? on an untreated background, as well as a wet weight of weeds up to 110.4-108.2 g/m?, respectively, was noted. The maximum amount of digestible forms of nitrate nitrogen is observed when using deep combined treatments up to 7.5-8.1 mg/kg of soil. The greatest increase in the content of humus in the soil layer of 0-30 cm was noted according to the results of the use of 2-tier tillage – up to 3.99 %, which exceeds the initial value by 0.38 %. The highest yield was obtained when using different-depth treatments – 5.19 t/ha without protection and 5.45-5.52 t/ha with the use of herbicides. The maximum productivity of grain crops was also obtained in variants with combined treatments and amounts to 5.93 thousand feed units/ha against the background without protection, and 6.50 thousand feed units/ha against the background of chemicalization.
Comparative analysis of water salinity of Lenkoranchay and Vilyashchay rivers
Authors: Mammadova Aytan Suliddin kyzy
Published: November 2023

The article discusses the changes in the content of the composition of salts and ions in the rivers of Lenkoranchay and Vilyashchay, which belong to the southern region of Azerbaijan. To study changes in water quality composition comparative analyzes were performed in 2003-2018 years. Comparison shows that over the past 15 years, the salt composition of the Lenkoranchay and Vilyashchay rivers has changed depending on the year and season. It was found out that in 2018 the salinity (according to the dry residue) in the waters of Vilyashchay almost doubled compared to 2003. And in the composition of Lenkoranchay water in the same years, this indicator increased from 0.522 to 0.680 g / l. In the composition of the waters under study, the amount of salt ions, pH and silt content were also studied. It was revealed that there have been significant changes in the content of these indicators depending on the rivers.
Leaf fertilizing in the technology of cultivation of seed hemp in the conditions of the Middle Volga Region
Authors: Bakulova Irina Vladimirovna
Published: November 2023

The research was carried out in order to study the influence of seeding rates and foliar treatment of cannabis plants in the Penza region. The scheme of the experiment included the following factors: seeding rates (factor A) - 2.0 million/ha, 2.5 million/ha, 3.0 million/ha and foliar fertilization of plants (factor B) - control (without treatment), Izagri Nitrogen (3 l/ha), Izagri Phosphorus (3 l/ha) were studied, Izagri Vita (1 l/ha), Humate +7 (1 l/ha). The soil of the experimental site is represented by leached, heavy loamy chernozem with a humus content of 4.6%. The treatment of vegetative plants with Izagri Nitrogen and Izagri Phosphorus preparations had a positive effect on the processes of growth, development and morphological signs. The height and technical length of the stem increased in comparison with the control, the length of the inflorescence was the greatest in the variants with the treatment of Izagri Nitrogen (84 cm) and Izagri Phosphorus (78 cm). The use of foliar spraying of cannabis crops with liquid fertilizers Izagri Nitrogen and Izagri Vita increased the yield of stems by 0.78-0.9 t/ha (5.3-6.1%), the total yield of fiber increased to 4.79-4.95 t/ha, and its content to 33.2-33.5% at 32.6% and 4.6 t/ha under control. Foliar spraying of cannabis Humate+7 crops at a rate of consumption of 1 l/ha provides a high seed yield of 1.08 t/ha at 0.90 t/ha under control.
Evaluation of the effectiveness of treatment of cows with persistent ovarian corpus luteum
Authors: Semivolos Aleksandr Mephodievich , Semivolos Sergey Aleksandrovich , Tokarev Dmitry Nikolaevich
Published: November 2023

The article presents the results of studies on the use of the drug regostenol in persistent ovarian corpus luteum. The studies were carried out in JSC "PZ" Meliorator "of the Saratov region, where they noted the widespread obstetric and gynecological pathology in cows. Among these diseases, 43.91% are functional disorders of the ovaries. Persistent corpus luteum was recorded in 12.69% of animals. After the use of regostenol, 91.67% of cows showed the stage of excitation of the sexual cycle, and the time for the onset of the first sexual cycle came in 5.2 ± 0.03 days. In the control group of cows, no manifestations of sexual cyclicity occurred. Experimental studies have shown that after the use of regostenol in cows with a persistent corpus luteum, 75.0% of animals became pregnant with an insemination index of 1.8. Whereas in the control group, all animals remained infertile. The data obtained indicate the expediency of using the drug, since it allows achieving the manifestation of sexual cyclicity after prolonged anaphradesia and fertilization of most of the cows after insemination.
Statistical evaluation of reliability indicators of potato harvesting process
Authors: Ovchinnikova Natalia Ivanovna , Bonnet Vyacheslav Vladimirovich , Kosareva Anna Viktorovna , Bykova Marija Aleksandrovna , Bonnet Yakov Vyacheslavovich
Published: November 2023

According to agrotechnical requirements, the technological process of potato harvesting should be carried out in a short period, with minimal losses of the grown yield and preservation of its quality. The fulfillment of these requirements depends on the organization of harvesting operations, the qualifications of employees, the technologies involved, the technical aids used, as well as natural and climatic conditions. Based on this, the authors propose to consider the potato harvesting process as the functioning system "man-machine-environment-transport", the main evaluation indicator of which is its reliability, determined by the probability of reliable operation of the system. Basing on the method of time-lapse observations, the analysis of the time characteristics of the operational and inoperable states of the system arising from the reasons of the "failure" elements included to it is carried out. Experimental studies were conducted during three harvesting seasons in the training farm of the Irkutsk State Agrarian University using a potato harvesting unit PPC-2-01+МТZ-80 by direct combining. Statistical processing of the empirical data obtained enabled to reveal a number of regularities in the reliability indicators of the potato harvesting process and quantify the unproductive time waste during the working day when performing managerial, technical and technological functions.
Evaluation of allelic polymorphism of apple tree resistance genes to scab
Authors: Ulyanovskaya Elena Vladimirovna , Chernutskaya Evgenia Anatolievna , Balapanov Ilnur Malikovich , Tokmakov Sergey Vyacheslavovich
Published: November 2023

The article presents the data of molecular genetic analysis for several genes of the Rvi system of resistance to Venturia inaequalis (Cooke) G. Winter (Rvi1, Rvi6, Rvi8, Rvi9, Rvi11, Rvi14, Rvi16, Rvi17) of the collection and new breeding material of the apple tree (Malus ? domestica Borkh.) of different ploidy, ecological, geographic and genetic origin. We used the CTAB method, which was previously modified in FSBSI NCFSCHVW for more complete purification of DNA samples during extraction. SSR-markers and SCAR-markers linked to the desired 9 genes were used: Rvi1 – CH01D03; Rvi4 – CH02c02a; Rvi6 – CH-Vf1, VfC; Rvi8 – OPL19; Rvi9, Rvi11 – CH05e03; Rvi14 – HB09; Rvi16 – NH030a; Rvi17 – CH-Vf1. The experiment was carried out with the participation of 53 apple samples, including: 17 varieties, 4 elite and 32 hybrid forms of domestic breeding. According to the data obtained, the following genes were classified as quite rare in the studied sample of samples: Rvi9, Rvi16; the presence of genes has not been established: Rvi8, Rvi11, Rvi17. Revealed that among the new breeding material of the apple tree, the Rvi6 gene is the most common, its frequency of occurrence is 62.5%. The study of the allelic polymorphism of several target genes of the Rvi set made it possible to identify promising apple samples for breeding use – carriers of 2–3 resistance genes to Venturia inaequalis (Cooke) G. Winter. According to the DNA marking data, varieties and forms of domestic breeding were selected: Zarya Stavropol'ya, Nika, 12/2-20-75, 17/1-6-72 (carriers of the Rvi1, Rvi6, Rvi14 genes) as promising donors to enhance the efficiency of apple breeding technology for long-term resistance to scab. The data obtained are important for the formation of an identified collection of Malus Mill., the selection of new valuable donors to optimize a number of key stages of the breeding process for long-term resistance to the pathogen by pyramiding the target genes.
DNA testing of allelic polymorphism of IGF-1, GDF 5, GH, GHR genes in young beef cattle
Authors: Gajiyev Zakir Kamilovich , Surzhikovа Evgeniya Semenovna , Evlagina Darya Dmitrievna , Surov Alexander Ivanovich , Shumaenko Svetlana Nikolaevna
Published: November 2023

The development and improvement of methodologies that allow assessing the features of the gene pool of domestic, as well as local breeds, farm animals by breeding-significant characteristics for associative research is of both fundamental and applied importance. To carry out breeding work with cattle to increase meat productivity (breeding and commodity farms), it is advisable to consider DNA genotyping as an additional criterion for breeding and selection of animals. In this study, using PCR-PDRF analysis, the frequency of occurrence of the allele spectrum of genes was determined: insulin-like growth factor-1 (IGF?1), differentiating growth factor (GDF5), somatotropin (GH ? growth hormone), growth hormone receptor (GHR), in order to study the breed and population characteristics of repair young cattle cattle of different breeds: Hereford and Kazakh white-headed, bred in farms of the Stavropol Territory. In the course of the study, complex genotypes were identified, the allelic profile of which is represented by eight and seven desirable alleles of four genes in replacement young animals of the Kazakh white-headed breed and six marker alleles of three and four genes in the Hereford breed. It was also noted that the heterozygosity test in the two studied samples of animals for all genes was negative and ranged from -0.10 to -0.44.
WHILE DREAMING. IMAGINARY AND FANTASTICAL SPACE (“THE CAVE OF SLEEP” BY N. GUMILEV, “DREAM” BY N. ZABOLOTSKY AND “DREAM” BY A. GRIN)
Authors:   Russian State University for the Humanities, Malkina Viktoria Ya.
Published: November 2023

The article analyses the form of dreaming in lyric poetry. It is considered, firstly, as a representation of the visual in literature. Secondly, the question of how dreaming in a lyrical poem can relate to the categories of the fantastical world-image and the imaginary world of the hero is investigated. The material is three poems in which dream is not only mentioned or serves as a motif, but is actually a reality (world, space) of dream existing within the literary reality of the poem. Thus the category of border as both a connecting and disconnecting entity is also significant. The conclusion is made about how to differentiate between dream as a phenomenon of the fantasy world-image and dream as a type of the hero’s imaginary world
INTERDISCIPLINARY APPROACH TO THE STUDY OF THE AUTOFICTION GENRE AS A PHENOMENON OF MODERN LITERATURE
Authors:   Maxim Gorky Institute of Literature and Creative Writing, Belogortsev Andrey D.
Published: November 2023

The article is about an issue of researching the autofiction genre as a phenomenon of modern literature. The interdisciplinary nature of the described phenomenon is substantiated, arguments are given in favor of the close relationship between literary theory, philosophy, history, psychology, sociology, narratology, ethnography, psychoanalysis in the works of the autofiction genre. Autofiction is presented as an experimental platform for obtaining new scientific knowledge in the field of various sciences. Author considers popular rules for creating works in the autofiction genre, such as demolition of the genre construction, “author’s surrogate”, “self-insertion”, therapeutic effect, discussion of non-standard issues. Exceptions to the rules are given on the examples of the works by A. Sekisov “The God of Anxiety” and G.V. Vrublevskaya “Half of a suitcase, or Writers are not born writers”: the lack of professional literary education of the author, the mixing of the autofiction genre with classical prose, etc., which do not affect the popularity of the authors and their literary works. The conclusion is made about the premature decision about the positive prospects for the development of the genre and the need to use interdisciplinary approaches in the study of autofiction as a phenomenon of modern literature.
Mi c-a-s-a. Una metáfora atravesada por la noción de hogar
Authors: Beltrán Deisy
Published: November 2023

A través de la casa se indaga sobre las relaciones y vínculos que se tejen dentro del núcleo familiar, entendiendo cómo estas pueden ser fluctuantes debido a las dinámicas del hogar. De manera que, la casa se encuentra atravesada por una serie de experiencias que transforman las vivencias individuales y colectivas, las cuales narran historias de vida sobre como construimos nuestro cuerpocasa a partir de lo que nos duele o percibimos de este espacio, haciendo referencia a diferentes procesos de creación plástica que configuran un lenguaje artístico sobre conceptos tales como: la memoria, la fractura y la intimidad. Por lo tanto, se aborda la autoetnografía como un medio para comprender como la casa puede asociarse a procesos culturales y artísticos que surgen desde el trabajo de campo con comunidades indígenas Arhuacas y mujeres cuidadoras, quienes conciben y apropian una idea sobre el hogar mediante técnicas etnográficas como los diarios de campo, la cartografía corporal y el dibujo.
Preplacing tarsorrhaphy sutures for bulbus oculi proptosis in Pomeranian dogs
Authors: Cikita Diah Ayu , Yulianto Maria Elita Reynara Novena , Rachmawati Maulinda , Subagio Reza Taufiq , Waskita Pranyata Tangguh , Widianti Ranny Indah
Published: November 2023

Proptosis of the bulbus oculi is a disorder of the eyeball protruding from the orbit, which generally occurs due to trauma. This paper reports the treatment of bulbus oculi proptosis in Pomeranian dogs using tarsorrhaphy. Tarsorrhaphy is a surgical procedure used to unite part or all of the upper and lower eyelids to close part or all of the eyes. After tarsorrhaphy, the dog was administered an antibiotic combination of penicillin and streptomycin, anti-inflammatory and analgesic meloxicam, and fluid therapy using Ringer's lactate. The antibiotic amoxicillin/clavulanic acid and the blood-boosting drug Fufang E'jiao Jiang were administered orally for 14 days after tarsorrhaphy as prophylactic treatment. Methylprednisolone was also administered orally as an anti-inflammatory agent for 3 days after tarsorrhaphy. Hospitalization was performed for 24 h, and during observation, discharge was observed in the tarsorrhaphy area. Weekly monitoring at the clinic is recommended for owners to observe the condition of the dog’s eyes and tarsorrhaphy sutures
Bioavailability properties of intravaginal implants made from chitosan-PEG-PCL in simulated vaginal fluid and vagina of cattle
Authors: Yessa Elma Yuliani , Wientarsih Ietje , Purwantara Bambang , Amrozi Amrozi , Ulum Mokhamad Fakhrul
Published: November 2023

This study aimed to design and evaluate the bioavailability of intravaginal implants made from the biodegradable polymer chitosan-polyethylene glycol (PEG)-polycaprolactone (PCL) in simulated vaginal fluid (SVF) and the cow vagina. Implants were prepared using melt-ing and molding techniques with 26 different formulations. Next, the implants were immersed in 40 mL of SVF at a temperature of 37.8 ℃ and changes in implant morphology were observed every day until day 5. Implants that survived until day five were tested for further availability in the cow's vagina and observed daily for 2 weeks. The immersion test on SVF results showed that implants with a PEG content of 75-85% melt more quickly than implants with a PEG content of 20-72%. Implants containing 1-10% PCL eroded more rapidly in the SVF than those containing 22-80% PCL. Implants containing chitosan can remain stable in the SVF for longer than implants without chitosan. The bioavailability test in the cow's vagina showed that implants 21-23 persisted until the 10th day, while implants 24-26 were expelled from the cow's vagina during the test. Implant 21-23 is a promising formulation for the development of biodegradable intravaginal implants. By adjusting the composition of chitosan (between 14-18 wt%), PEG (maximum 72 wt%), and PCL (minimum 20 wt%), intravaginal implants were able to extend the bioavailability of both simulated vaginal fluid and the vagina of cattle.
Psychoanalytic and Sociobiological Factors in Attitudes toward Persons with Disabilities: Discussion Focused on Rehabilitation Counseling Profession
Authors: Thomas Kenneth , Han Kim Jeong
Published: November 2023

This study's goal was to examine, expand upon, and update a chapter that was first printed in a relatively small number of copies of the book titled Essays and Research on Disability1. Thomas was the sole author of the original chapter, which discussed how attitudes about disability develop from a psychoanalytic and sociobiological perspective. Kin, reciprocal, and induced altruism were the first three altruism principles in sociobiology that were covered in this study. Then, Karen Horney's neo-Freudian viewpoint (i.e., less emphasis on sex and focused more on the social environment and culture regarding personality development) and traditional Freudian theories (such as castration anxiety, loss of love, and loss of the object) were tied to sociobiology, and this relationship was further addressed in terms of the evolution of attitude toward handicap. Then, recommendations were offered across a broad range of rehabilitation counseling services and educational practices that might be improved by using these insights, both clinically and politically. Finally, the present study extends this discussion by addressing similar concerns in the areas of counseling service priorities, multicultural rehabilitation counseling, and identity politics.
Implementasi Pembelajaran Berbasis Sikap Ilmiah dan Keterampilan Proses Sains: Bagaimana Respon Mahasiswa Rumpun Non-Sains?
Authors: Syazali Muhammad , Erfan Muhammad
Published: November 2023

Learning based on scientific attitudes and scientific process skills is common among science students. However, this learning is almost never applied to non-science students, especially Primary School Teacher Education (PGSD) students at Mataram University. The aim of this research is to describe student responses to the implementation of learning based on these two aspects of science. This descriptive research using the survey method was carried out on PGSD students who were taking Basic Natural Sciences (IKD) courses in the odd semester of the 2021-2022 Academic Year. The sample consisted of 167 students who were determined using the purposive sampling method. Response data on learning implementation was measured using a questionnaire instrument which was distributed to respondents via a link in the Google Form application. Based on the survey results, we found that 53.3% of students stated that they had studied science through the research process, and the results were written in the form of scientific papers. As for the impression, the response from all students was positive. The details were 17.4% felt very happy, 53.3% were happy, and the remaining 29.3% answered quite happy. This is encouraged because they benefit from learning based on process skills and scientific attitudes. However, there are still 15.6% of students who experience difficulties in the process. The cause is the obstacles experienced by most of them (87.4%), and there are also students (6%) who feel that the time given is not enough. Some of the difficulties experienced by students include finding research problems (25.1%), formulating titles (26.9%), designing research activities (18%), and collecting data (29.9%). When writing scientific papers, the greatest difficulty lies in writing results and discussion (63.5%), followed by writing research methods (19.8), and the rest is in writing the abstract, introduction, conclusion and bibliography. The sample paper media used can help students in writing papers, but as many as 95.2% of students need additional facilities to practice their writing skills.
Penerapan Metode Role Playing Berbantuan Media Film Untuk Meningkatkan Keaktifan dan Hasil Belajar Siswa Pada Mata Pelajaran Sosiologi Kelas XI IPS 1 SMAN 1 Pringgabaya
Authors: Nur Aulia Sendi , Suryanti Ni Made Novi , Malik Imam , Masyhuri Masyhuri , Adhecelan Herdias
Published: November 2023

Salah satu metode pembelajaran sosial adalah metode pembelajaran role playing yang melibatkan pemberian karakter kepada siswa untuk dimainkan dalam konten atau peristiwa yang disajikan sebagai kisah langsung. Keaktifan dan Hasil Belajar Siswa lah yang menjadi tujuan dalam penelitian ini untuk dapat diketahui. Studi ini menggunakan penelitian tindakan kelas yang terdiri dari 2 siklus dan setiap siklus terdiri dari 3 pertemuan. Tahapan penyajian data, reduksi data, dan kesimpulan digunakan untuk mengkaji data pada penelitian ini. Observasi, tes, dokumentasi, dan wawancara merupakan instrumen penelitian yang digunakan. Hasil temuan menunjukkan keaktifan siswa pada siklus ke-I sebeser 62,5% atau 20 siswa yg aktif dari 32 siswa di kelas mengalami peningkatan sebesar 21,9% menjadi 84,4% atau 27 siswa yang aktif. Sedangkan pada hasil belajar, sikluas 1 menunjukkan data sebesar 59% atau 17 siswa yang tuntas kemudian pada siklus 2 mengalami peningkatan menjadi 84,4% atau 27 siswa yang tuntas dari 32 siswa di kelas. Data statistik ini membuktikan bahwa penggunaan model role playing berbantuan media film dapat meningkatkan keaktifan dan hasil belajar siswa kelas XII.
ANALISIS PENGARUH TINGKAT LITERASI KEUANGAN TERHADAP PENGELOLAAN KEUANGAN PADA PELAKU UMKM DI GUNUNGSARI
Authors: Ulfiany Silpya Raudatul , Pusparini Herlina , Nurabiah Nurabiah
Published: November 2023

This study aims to determine the effect of financial literacy level on financial management in MSME actors in Gunungsari District. The type of research used in this study is associative with a quantitative approach. The sample set in this study is 35 units of Micro, Small and Medium Enterprises (MSMEs) made from wood, bamboo and rattan with a total of 70 respondents in Gunungsari District. The data collection technique in this study was a questionnaire. The results showed that financial literacy has a positive and significant effect on financial management. So this indicates that the higher the level of financial literacy owned, the better the financial behavior.
CIRURGIA ROBÓTICA NO BRASIL: UM PANORAMA GERAL A PARTIR DE UMA REVISÃO INTEGRATIVA DE LITERATURA
Authors: Farias Enoi Alves Silvestre , Medeiros Camila Soares Barros Fernandes , Messias Maria Vitória Feitosa , Silva Vinicius Marcel , Ramalho Vitória Vieira Melo , Lucena Alinne Beserra de
Published: November 2023

Introdução: A busca permanente pelos melhores resultados na medicina fez com que a tecnologia de excelência fosse expandida entre todas as áreas. Nesse contexto, tem-se a cirurgia robótica, uma tecnol
Dípteros necrófagos do Brasil:
Authors: Garção Neto Carlos Henrique , Queiroz Margareth Maria de Carvalho , Cortinhas Lucas Barbosa , Mendonça Paloma Martins , Duarte Marina Lopes , Barbosa Tatiane Aparecida Nascimento
Published: November 2023

A obra traz uma compilação das últimas três décadas de pesquisa sobre a composição da fauna de dípteros necrófagos nas cinco regiões do Brasil, com informações sobre distribuição geográfica das espécies, substratos e ambientes de coleta, bem como sobre suas relevâncias como evidências criminais na entomologia forense.
El Museísmo Pedagógico en España: Actualidad y Perspectivas, luces y sombras
Authors: Peña Saavedra Vicente
Published: November 2023

Desde los años de cambio de siglo se aprecia un resurgimiento muy sensible de la museología de la educación a escala mundial. Así se pone de manifiesto en una reciente publicación titulada Os museos da educación en internet (2004), que ha sido realizada bajo la dirección del Dr. Vicente Peña Saavedra, profesor de la Universidad de Santiago de Compostela y Coordinador Científico del Museo Pedagóxico de Galicia (Mupeda). A esta corriente en sostenido proceso de ebullición, no son en absoluto ajenos a los entornos territoriales americano y europeo, tal y como se evidencia en la misma obra, sino que por el contrario ambos han venido actuando como auténticas locomotoras de este rebrote museográfico de nuevo cuño y moderna orientación, en sintonía con los avances y paradigmas que se han venido gestando en los últimos tiempos en la esferas museológica y pedagógica. Pero en este caso se registra, correlativamente, un fenómeno tanto o más importante que el anterior. Consiste en una reciente dinámica de aproximación y articulación de las iniciativas museísticas especializadas en materia educativa que han tomado cuerpo en las últimas décadas o que se encuentran en fase emergente en la actualidad.
Early 20th Century American Schooling, Education Sciences and Making Social Exclusion
Authors: Popkewitz Thomas S.
Published: November 2023

Schooling embodies salvation themes of North American and European modernity. The salvation themes are mutations of Enlightenments’ project of emancipation through the use of reason and rationality in achieving a universal progress for humanity. The school was produced the modes of life in which the cosmopolitan liberty and freedom could be produced. The emancipatory project entailed cultural theses about the child and society that entailed ironies and paradoxes of modernity in at least two different layers. First, while the notions of cosmopolitanism were to transcend the local and provincial, it was linked to the formation of the modern state that was dependent on for its existence. Second, the hopes of cosmopolitan freedom embodied fears about dangers and dangerous the people who did not embody the qualities and characteristics of the new citizen. This discussion explores the manner in which hopes and fears are embedded in the practices of the pedagogical sciences at the turn of 20th Century concerned with planning in which the child and the family were and should be. The practices of sciences embodied a comparative style of reason through which the hope for inclusion established principles that divided and differentiated particular qualities and people so as exclude in the inclusionary gestures.