bluuebunny/crossref_metadata_2025 huggingface dataset:
Idiopathic central diabetes insipidus in a large cohort of patients; The hypopituitarism ENEA rare observational (HEROS) study
Authors: Iraqi Hiba Masri , Shimon Ilan , Pigarova Ekaterina , Colao Annamaria , Baraf Lior , Tsoli Marina , Doknic Mirjana , Bitti Silvia Ricci , Giordano Roberta , Barbot Mattia , Akirov Amit , Witek Przemyslaw , Serebro Merav , Auer Matthias , Tóth Miklós
Published: August 2022

Central Diabetes Insipidus (CDI) is mainly associated with structural pathologies of the hypothalamic-pituitary area. Etiologies underlying CDI are identified in most patients, however idiopathic CDI is reported in 13-17% of cases after excluding other etiologies. The Hypopituitarism ENEA Rare Observational Study (HEROS study) retrospectively collected data of patients with idiopathic CDI from 14 pituitary centers in 9 countries.The cohort included 92 patients (59 females), mean age at diagnosis was 35.4±20.7 years, and a mean follow up of 18.2±14.5 years following CDI diagnosis. In 6 women, diagnosis was related to pregnancy. Of 83 patients with available data on pituitary imaging, 40 had normal sellar imaging, and 43 had pathology of the posterior pituitary or the stalk, including loss of the bright spot, posterior pituitary atrophy or stalk enlargement. Anterior pituitary hormone deficiencies at presentation included hypogonadism in 6 patients (5 females), and hypocortisolism in one; during follow-up new anterior pituitary deficiencies developed in 6 patients. Replacement treatment with desmopressin was given to all patients except one, usually with an oral preparation. During follow up, no underlying disease causing CDI was identified in any patient.Conclusions: patients with idiopathic CDI following investigation at baseline are stable with no specific etiology depicted during long-term follow-up.
Fiber Glass/Kenaf Reinforced Thermoset Composite with Microcrystalline Cellulose as Filler in a Different Fluid Immersion
Authors: Palmiyanto Martinus Heru , Surojo Eko , Ariawan Dody , Imaduddin Fitrian
Published: August 2022

Microcrystalline cellulose (MCC) is one of the good and environmentally friendly natural rigid fillers used in polymer matrix composites to improve mechanical properties. However, the reliability of this MCC composite cannot be ensured in a humid environment or submerged in water with different pH. This study investigated the addition of MCC filler to the absorption of distilled water (pH 7), seawater (pH8), and acid solution (pH 3), flexural strength, and flexural modulus of kenaf/glass fiber reinforced polymer composites. Soaking the composite for 60 days in distilled water and seawater showed an increase in the concentration of water absorption. Water absorption by the kenaf fibers causes the fibers to swell and provides an expansion to the matrix resulting in crack propagation and the growth of new cracks in the matrix. The behavior of the composite in an acidic solution shows a mass loss, and the matrix erodes on the surface and inside the material. The flexural strength and flexural modulus of the composite decreased at all immersions. The addition of MCC as a reinforcing filler for thermoset composites increases the interfacial interaction between the matrix and the kenaf/glass fiber. The improved mechanical properties of MCC-filled composites in different pH environments create opportunities and reliability for use in different engineering applications.
Two-step flotation and reverse flotation circuits of iron oxide and its process minerology
Authors: Hou Ying , Lin Song , Fu Guohui , Gai Zhuang , Yang Guang , Sobhy Ahmed
Published: August 2022

Mining operations usually provide ore of varying characteristics. Similarly, for Donganshan Sintering Plant, the charges in iron oxide ore especially prior flotation process were investigated by conducting mineral liberation analyzer “MLA”. This in-deep study of process mineralogy explored and analyzed the mechanism of difficulty to obtain high-efficient flotation process. The MLA analysis results showed also that the main useful minerals in this ore are magnetite/hematite, and the main gangue minerals is quartz, followed by chlorite and ankerite. In addition, two-step “direct then reverse” and one step “reverse” flotation experiments were carried out and produced iron oxide concentrates of 48.91% and 49.45% yield; 65.03% and 65.22% grade; 70.96% and 72.08% recovery respectively. Besides, the process flow sheet was simplified with reduced reagent consumptions.
Low Degree / High Degree polynomial decomposition in a large population of healthy normal eyes and how it compares to the Zernike polynomials: an observational study
Authors: Karcenty Mickael , Barugel Raphael , Karcenty John-Evan , Debellemanière Guillaume , Rampat Radhika , Mazharian Adrien , Malet Jacques , Dumas Laurent , Gatinel Damien
Published: August 2022

Purpose: To evaluate and compare the ocular aberrations in healthy normal eyes with Zernike versus Low Degree/High Degree (LD/HD) coefficients using OPD-Scan III wavefront sampling.Methods: Retrospective case series. Ocular wavefront acquisition using automated skiascopy was performed in mesopic conditions on refractive surgery candidates. Root Mean Square (RMS) values were computed for 6 mm pupils and aberration data from the 1st to the 6th order were exported.A Principal Component Analysis was performed to investigate which of the two classifications explained better the variance of the wave aberrations for their respective higher order wavefront components.Results: Data from 3827 eyes of 2110 patients were analyzed. Z1-1 (horizontal tilt) and Z11 (vertical tilt) modes had a mean absolute RMS of 0.299 +/- 0.233 μm and 0.242 +/- 0.194 μm. G1-1 and G11 had a mean absolute RMS of 0.051 +/- 0.044 μm and 0.045 +/- 0.039 μm. Total Zernike coma (Z3-1, Z31, Z5-1 and Z51) had a mean absolute RMS of 0.168 +/- 0.089 μm. Total LD/HD coma (G3-1, G31, G5-1 and G51) had a mean absolute RMS of 0.488 +/- 0.261 μm. Zernike Spherical Aberration (SA = Z40) had a mean absolute RMS of 0.093 +/- 0.070 μm while LD/HD SA (Z40) had a mean absolute RMS of 0.642 +/- 0.481 μm. PCA demonstrated that the LD/HD classification provided a new set of basis functions that better fitted the variance of HOAs, compared with the Zernike classification.Conclusion: This study standardizes Zernike and LD/HD based wavefront reconstructions using the OPD-Scan III in mesopic conditions. LD/HD classifications appear to offer a more efficient description of the eye’s aberrations. The main differences of both classifications are expanded upon.
Hsa_circ_0008344 promotes glioma cells proliferation, invasion and migration via miR-556- 5p/NLRP3/NF-κB signaling pathway
Authors: Xue LiPing , Lu Bin , CaiQi Jiang , Sun Ke , He QiBin , Jiang Hao , Ding Peng
Published: August 2022

The circular RNAs (circRNA) are becoming more important in cancer development. However, the functional role of circRNA in glioblastoma is still remain to be deeply studied. In the current study, we used CCK-8, flow cytometry, transwell, western blot, and RT-PCR assays to determine the expression of has_circ_0008344 in different glioma cells. Results showed that the expression level of hsa_circ_0008344 in glioma cells was remarkably higher than normal HCGC cells. Down-regulation of hsa_circ_0008344 significantly decreased the proliferation rate, increased apoptotic rate, impaired invasion and migration capacity in U87MG and U251MGA cells. We found that miR-513a-5p mimics could significantly reverse the over-expression of hsa_circ_0008344 and enhancing the knocking-down of hsa_circ_0008344. Moreover, NLRP3 promoted the biological activities of glioma cells coordinately with hsa_circ_0008344 and could reverse the impact of miR-513a-5p mimics on over-expression of hsa_circ_0008344 treated glioma cells. Also activated p-NF-κB involved in the invasion and migration of glioma cells. In conclusion, the present study demonstrates that hsa_circ_0008344 is up-regulated in glioma in vitro and promoted the proliferation activity, invasion and migration of glioma cells by ameliorating miR-556-5p/NLRP3/NF-κB signaling pathway. Our results may contribute to the diagnosis and treatment of glioma in the future.
TRβ gene expression of Sprague- Dawley rats’ hypothyroidism treated with non-Protein amino acid beta-amino butyric acid (βABA)
Authors: Mohammed Saja Aied , Jasim Mohammed Abbas
Published: August 2022

Thyroid receptors TRα, TRβ, and other receptor subunits belong to the nuclear receptor family as they mediate thyroid hormone signaling to regulate a wide range of physiological processes including growth and metabolism. Our study aimed to investigate the effect of beta-aminobutyric acid (βABA) on the gene expression of the TRβ gene in 30 male Sprague-Dawley rats with hypothyroidism and normal condition. Animals were divided into six groups, three of which developed hypothyroidism by intraperitoneal injection with propylthiouracil (PTU) daily for 15 days, while the other three groups did not develop hypothyroidism and remained healthy. Then four groups of rats (two infected and two normal groups) were injected with two concentrations of (βABA) (100 and 200 mg/kg body weight) three times a week for two weeks. An infected control group was left for βABA treated groups and a normal control group was left for all groups. The gene expression level of the TRβ gene was measured, and it was found that there was a decrease in relation to the infected control group only while the expression value increased in the infected and treated groups treated with amino acid in both concentrations and with regard to the normal and injected groups with (βABA), the gene expression increased in the group injected with a concentration of 100 mg/kg only. We conclude that BABA had a positive role in regulating the secretion of pro-and anti-inflammatory cytokines under studied concentrations besides it had a positive role in increasing the expression of the TRβ gene.
Stoma Versus Anastomosis After Sphincter-Sparing Rectal Cancer Resection; the Impact on Health-Related Quality of Life
Authors: Algie Jelle P.A. , Kooten Robert T. , Tollenaar Rob A.E.M. , Wouters Michel W.J.M. , Peeters Koen C.M.J. , Dekker Jan Willem T.
Published: August 2022

Background
Surgical resection is the mainstay of curative treatment for rectal cancer. Post-operative complications, low anterior resection syndrome (LARS) and the presence of a stoma may influence the quality of life after surgery. This study aimed to gain more insights into the long-term trade-off between stoma and anastomosis.
Methods
All patients who underwent sphincter-sparing surgical resection for rectal cancer in the Leiden University Medical Center and the Reinier de Graaf Gasthuis between January 2012 and January 2016 were included. Patients received the following questionnaires: EORTC-QLQ-CR29, EORTC-QLQ-C30, EQ-5D-5L and the LARS-score. A comparison was made between patients with a stoma and without a stoma after follow-up.
Results
Some 210 patients were included of which 149 returned the questionnaires (70.9%), after a mean follow-up of 3.69 years. Overall quality of life was not significantly different in patients with and without stoma after follow-up using the EORTC-QLQ-C30 (p = 0.15) or EQ-5D-5L (p = 0.28). However, after multivariate analysis, a significant difference was found for the presence of a stoma on global health status (p = 0.01) and physical functioning (p < 0.01). Additionally, there was no difference detected in the quality of life between patients with major-LARS or a stoma.
Conclusion
This study shows that, after correction for possible confounders, a stoma is associated with lower global health status and physical functioning. However, no differences were found in health-related quality of life between patients with major-LARS and patients with a stoma. This suggests that the choice between stoma and anastomosis is mainly preferential, and that shared decision-making is required.
Benefit-sharing in International Law Post-2020 Global Biodiversity Framework and reciprocity
Authors: Sirakaya Aysegül
Published: August 2022

Benefit-sharing is a twofold concept that appears both in the realm of human rights law and environmental law. This is because the achievement of many human rights objectives such as those listed under the UN Sustainable Development Goals inherently depends on the maintenance of a healthy environment (A/HRC/19/34, A/RES/70/1). The lack of achievement related to environmental objectives can therefore jeopardize the achievement of human rights objectives. The Special Rapporteur on the issue of human rights obligations relating to the enjoyment of a safe, clean, healthy, and sustainable environment states that the “enormous problem is that [biodiversity agreements] have often not been effectively implemented and their goals have not been met.” (A/HRC/31/52) Consequently, the provenance and prevalence of benefit-sharing in international law need analysis from both the human rights and the environmental law perspectives as they are interdependent. This paper initiates a holistic study on benefit-sharing in international law by exploring its application in the Global Biodiversity Framework through interconnected principles of human rights and environmental law, theory of change, rights-based-approach, and intergenerational equity.
Detection of Changes in the Dynamics of Thermonuclear Plasmas to Improve the Prediction of Disruptions
Authors: CRACIUNESCU Teddy , Murari Andrea
Published: August 2022

In particular circumstances, nonlinear systems can collapse suddenly and abruptly. Anomalous detection is therefore an important task. Unfortunately, many phenomena occurring in complex systems out of equilibrium, such as disruptions in tokamak thermonuclear plasmas, cannot be modelled from first principles in real time compatible form and therefore data driven, machine learning techniques are often deployed. A typical issue, for training these tools, is the choice of the most adequate examples. Determining the intervals, in which the anomalous behaviours manifest themselves, is consequently a challenging but essential objective. In this paper a series of methods are deployed to determine when the plasma dynamics of the tokamak configuration varies, indicating the onset of drifts towards a form of collapse called disruption. The techniques rely on changes in various quantities derived from the time series of the main signals: from the embedding dimensions to the properties of recurrence plots and to indicators of transition to chaotic dynamics. The methods, being mathematically completely independent, provide quite robust indications about the intervals, in which the various signals manifest a predisruptive behaviour. Consequently, the signal samples, to be used for supervised machine learning predictors, can be defined precisely, on the basis of the plasma dynamics. This information can improve significantly not only the performance of machine learning classifiers but also the physical understanding of the phenomenon.
An NLP-Assisted Bayesian Time Series Analysis for Prevalence of Twitter Cyberbullying During the COVID-19 Pandemic
Authors: Perez Christopher , Karmakar Sayar
Published: August 2022

COVID-19 has brought about many changes in social dynamics. Stay-at-home orders and disruptions in school teaching can influence bullying behavior in-person and online, both of which leading to negative outcomes in victims. To study cyberbullying specifically, 1 million tweets containing keywords associated with abuse were collected from the beginning of 2019 to the end of 2021 with the Twitter API search endpoint. A natural language processing model pre-trained on a Twitter corpus generated probabilities for the tweets being offensive and hateful. To overcome limitations of sampling, data was also collected using the count endpoint. The fraction of tweets from a given daily sample marked as abusive is multiplied to the number reported by the count endpoint. Once these adjusted counts are assembled, a Bayesian autoregressive Poisson model allows one to study the mean trend and lag functions of the data and how they vary over time. The results reveal strong weekly and yearly seasonality in hateful speech but with slight differences across years that may be attributed to COVID-19.
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age
Authors: Hidaka Yosuke , Hashimoto Mamoru , Suehiro Takashi , Fukuhara Ryuji , Ishikawa Tomohisa , Tsunoda Naoko , Koyama Asuka , Honda Kazuki , Miyagawa Yusuke , Yoshiura Kazuhiro , Boku Shuken , Ishii Kazunari , Ikeda Manabu , Takebayashi Minoru
Published: August 2022

Background: Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases. CSF dynamics may play a crucial role in brain health in older people; nonetheless, such age-related changes have not been well elucidated. Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) is a neuroimaging phenotype of idiopathic normal-pressure hydrocephalus, which originates from impaired CSF dynamics. DESH is closely associated with aging; therefore, this study aimed to investigate the pathophysiology of DESH and determine age-related changes in CSF dynamics.Methods: Using magnetic resonance imaging, we investigated the pathophysiology of DESH by quantitatively evaluating the volumes of DESH-related regions (ventricles [VS], Sylvian fissure [SF], and subarachnoid spaces at high convexity and midline [SHM]) and brain parenchyma in community-dwelling individuals aged ≥65 years. DESH-related regions were assessed using a visual rating scale, and their volumes were measured using voxel-based morphometry. The brain parenchyma volumes were measured using FreeSurfer software.Results: The data of 1,356 individuals were analyzed, and 25 (1.8%) individuals had DESH. Regarding the relationships between the volume of each CSF space and age, VS and SF volumes increased with age, whereas SHM volume decreased with age. The VS and SF volumes increased as the whole brain volume decreased, whereas SHM volume decreased as the whole brain volume decreased; that is, SHM narrowed as brain atrophy progressed. Moreover, lower Mini-Mental State Examination scores were significantly associated with lower SHM volume and higher VS volume. These associations remained significant even when individuals with DESH were excluded.Conclusions: This study showed that the volume of high-convexity and medial subarachnoid spaces decreases with age; the human brain continuously progresses toward a “DESH-like” morphology with aging in community-dwelling older persons (i.e., DESH is an “accelerated aging stage” but not an “age-related disorder”). Our results indicated that brain atrophy is associated with the development of “DESH-like” morphology. In addition, this morphological change, as well as brain atrophy, is an important condition that can cause cognitive decline in older adults. Our findings highlight the importance of investigating the aging process of CSF dynamics in the human brain to preserve brain health in older people.
Limnobacter parvuscolonica sp. nov., thiosulfate-oxidizing bacterium isolated from lake water
Authors: Xamxidin Maripat , Huang Xin-Peng , Yang Xiang-Wei , Wang Tao , Chen Can , Wu Min
Published: August 2022

A novel bacterium, strain YS8-69T, was isolated from an inland closed lake, Xinjiang province, PR China. Comparative analysis of the 16S rRNA gene sequence shows the strain is affiliated to the genus Limnobacter, in the family Burkholderiaceae, with the highest similarities to Limnobacter alexandrii LZ-4T (98.93%), Limnobacter thiooxidans DSM 13612T (98.55%), Limnobacter humi NBRC 111650T (97.66%), and Limnobacter litoralis KP1-19T (97.04%). Strain YS8-69T was a Gram-stain-negative, rod-shaped, catalase- and oxidase-positive bacterium, and growth was observed at 4–40°C (optimum, 25°C), pH 7.0–10.0 (optimum, pH 7.0) and 0–3% (w/v) NaCl (optimum, 0.5%). It grew chemolithoautotrophically using thiosulfate. The principal fatty acids were C16:0, summed feature 3 (C16:1 ω7c and/or C16:1 ω6c), and summed feature 8 (C18:1 ω7c and/or C18:1 ω6c). The major respiratory quinone was Q-8 and predominant polar lipids were diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), phosphatidylethanolamine (PE), two unidentified aminolipids (AL1,2), two unidentified glycolipids (GL1,2), an unidentified amino phosphoglycolipid (APGL), two unidentifed phospholipid (PL1,2), and two unidentified lipids (L1,2). The average nucleotide identity (ANI) values between strain YS8-69T and L. thiooxidans JCM 13612T, L. humi DSM 111650T were 36% and 15.80% respectively. The final genome sequencing showed that length of strain YS8-69T genome was 3,162,663 bp, with 20 contigs, and 51.7 mol % of G + C content. Based on physiological, chemotaxonomic, genotypic characteristics, and phylogenetic results in the polyphasic taxonomy approach, we propose that strain YS8-69T represents a novel specie of the genus Limnobacter, for which the name Limnobacter parvuscolonica sp. nov. is proposed (type strain YS8-69T = MCCC 1K08015T = KCTC 92278T).
Using minimax techniques for nonlinear programming with many inequality constraints
Authors: Jiang Xiaowei , Yang Yueting , Cao Mingyuan , Zhou Guoling
Published: August 2022

In this paper, the inequality constrained optimization problem is transformed into a minimax problem. The objective function of the latter is essentially an exact penalty function, which can avoid the appearance of the ill-conditioning case when the penalty parameter is too large. For the max-value function containing 0 in minimax problem, most of the previous literatures approximate max{0, f i (x)}(i = 1, 2, · · · , m) one by one, while a modified flattened aggregate function proposed in this paper can approximate max{0, f 1 (x), · · · , f m (x)} in whole, which brings great convenience to solve the optimization problems with many constraints. By carefully updating aggregate parameters, the smooth unconstrained optimization problem is solved by a conjugate gradient method, which can usually save much computation of gradients and Hessians of constraint functions. Convergence of the proposed method is proven. A numerical procedure is given to implement the proposed method, and preliminary computational results show its efficiency.
A study on some physical and mechanical properties of molded thermal insulation materials produced from perlite and boric acid added forestry by-products
Authors: Efe Fatih Tuncay
Published: August 2022

Thousands of tons of bark and cones are produced each year in the forest products industry and the natural life cycle of forests. These raw materials are either burned or left in the forest. In both cases, it causes both environmental problems and a significant loss of economic potential. On the other hand, the demand for thermal insulation materials is increasing day by day, and more synthetic and fossil-based raw materials with negative environmental effects are consumed. In this study, some physical and mechanical properties of molded thermal insulation materials produced from natural raw materials were investigated experimentally. In this context, 15 types of sandwich panel materials containing honeycomb-shaped core were produced from pine (Pinus brutia Ten.) bark and cones. The mean moisture content, density, compressive strength, tensile strength perpendicular to the surface (Internal adhesion strength), tensile strength parallel to the surface (Tensile strength), and dimensional stability (width-length-thickness change) values of the materials were 10.600%, 269.717 kg/m3, 0.493.06 N/mm2, 0.011 N/mm2, 0.150 N/mm2 and − 0.156%, -0.054%, 0.942%, respectively. According to the results, it was determined that the increase in particle size and perlite ratio in the materials produced from the bark decreased the density. Moreover, it was found that the particle size-moisture content relationship and the perlite ratio-moisture content relationship varied in the materials containing bark and cones, that the mechanical properties were higher in the materials containing cones, and that the dimensional stability did not show a regular change.
Unmanned Aerial Vehicle assisted Intelligent approach to Manage the Resources for Defense Systems
Authors: Biswas Tarun , Anirudh Pokala , Raj Ayush , Rupesh Galla , Ray Anjan Kumar
Published: August 2022

Generally, resources are transported through manned transportation in a distant war zones. The manual transportation of the resources involve various constrains such as time consuming, risk, cost. Efficient management of these limited resources is one of the primary desiring factors to decide the fate of war. Compu-tationally, resource management is an non-deterministic polynomial hard (NP-hard) problem. In this work, several novel resources management algorithms are designed for defence systems by utilization the intelligence of UAV and Jaccard coefficient and Overlap coefficient mathematical support. The intelligent use of Unmanned Aerial Vehicles (UAVs) facilitate resources management in faster, less risky and efficient manner. The proposed UAV assisted resource management algorithms are analyzed and validated over various synthetic simulated war going situations data sets. The proposed algorithms show significant performance in the total service time, utilization of deployed UAVs and number of flights.
Treatment of pacemaker-induced superior vena cava syndrome by direct oral anticoagulant
Authors: Huang Weijun , Chen Yingwen , Liu Ziwei , Huang Yuli , Hu Yunzhao
Published: August 2022

Background
The use of cardiac implantable electronic device have grown substantially over the past two decades, lead related vascular issues are commonly encountered in clinical practice. Superior vena cava (SVC) syndrome due to pacemaker leads is an uncommon complication. Anticoagulation currently remains the mainstay of therapy to restore some degree of patency and relieve swelling. However, there is very limited clinical trials on direct oral anticoagulants (DOACs) .
Case presentation:
We report a case of a 80-year-old man who developed SVC syndrome after transvenous pacemaker implantation with symptoms of obstruction were significantly relieved after four months of DOACs. His symptoms had complete resolved nine months later.
Conclusions
DOACs are effective in the treatment of SVC syndrome after pacemaker implantation, representing an important new approach. It is a very good choice for patients who do not want to undergo interventional therapy.
Operando reconstruction towards CuI nanodots with favorable facets and stable Cu+ state for selective CO2-to-C2H4 conversion
Authors: Xue Wenjie , Liu Hongxia , Yang Ruoou , Liu Youwen , Xia Bao Yu , You Bo
Published: August 2022

Cu-based electrocatalysts with favorable facets and Cu+can boost CO2reduction to valuable multi-carbon products. However, the inevitable Cu+reduction and phase evolution usually result in poor performance. Herein, we fabricate CuI nanodots with favorable (220) facets and stable Cu+state, accomplished by operando reconstruction of Cu(OH)2under CO2- and I--contained electrolyte for enhanced CO2-to-C2H4conversion. In-situ Raman spectroscopy and thermodynamic potential analysis reveal the preferred formation of CuI which is stabilized by I-; vacuum gas electroresponse experiments and density functional theory (DFT) calculations demonstrate that CO2-related species induce the exposure of (220) of CuI. The resulting electrocatalysts exhibit a high C2H4Faradaic efficiency of 72.4% at a large current density of 800 mA cm-2and robust stability for 12 h in a flow cell. Combined in-situ ATR-SEIRS spectroscopic characterizations and DFT calculations indicate the (220) facets and stable Cu+in CuI synergistically facilitate CO2/*CO adsorption and *CO dimerization.
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Authors: Martins-Ferreira Ricardo , Leal Bárbara , Chaves João , Ciudad Laura , Samões Raquel , Silva António Martins da , Costa Paulo Pinho , Ballestar Esteban
Published: August 2022

Background: DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns and the direct relationship between cfDNA and apoptosis can potentially be used non-invasively to predict local alterations. In addition, direct detection of altered DNA methylation patterns performs well as a biomarker. In a previous study, we demonstrated marked DNA methylation alterations in brain tissue from patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) patients. Experimental Design: We performed DNA methylation profiling in cfDNA isolated from serum of MTLE patients and healthy controls using beadchip arrays followed by systematic bioinformatic analysis including deconvolution analysis and integration with DNase accessibility datasets. Results: Differential cfDNA methylation analysis showed overrepresentation of gene ontology terms and transcription factors related to central nervous system function and regulation. Deconvolution analysis of the DNA methylation datasets ruled out the possibility that the observed differences were due to changes in the proportional contribution of cortical neurons in cfDNA. Moreover, we found no overrepresentation of neuron- or glia-specific patterns in the described cfDNA methylation patterns. However, the MTLE-HS cfDNA methylation patterns featured significant overrepresentation of the epileptic DNA methylation alterations previously observed in hippocampus. Conclusions: Our results support the use of cfDNA methylation profiling as a rational approach to seeking non-invasive and reproducible epilepsy biomarkers.
Norepinephrine Boluses for Post Reperfusion Syndrome in Living Donor Liver Transplantation
Authors: Emara Moataz M. , Elsedeiq Mahmoud , Abdelkhalek Mostafa , Yassen Amr M , Elmorshedi Mohamed A
Published: August 2022

The authors have requested that this preprint be removed from Research Square.
Mannitol for Prevention of Acute Kidney Injury after Liver Transplantation: A Randomized Controlled Trial
Authors: Emara Moataz Maher , Diab Doaa Galal , Yassen Amr Mohamed , Abo-Zeid Maha A
Published: August 2022

Background: Acute kidney injury (AKI) is a common complication after liver transplantation, which is associated with increased morbidity and mortality. Therefore, this study investigated mannitol as an oxygen-free radical scavenger and its role in the prevention of early AKI after a living donor liver transplantation (LDLT).Methods: A total of 84 adult patients who underwent LDLT were randomly assigned to two equal groups: the M group, where patients received 1 g/kg mannitol 20%, or the S group, where patients received an equal volume of saline. The primary outcome was the incidence of early AKI, defined as a 0.3 mg/dl increase in the serum creatinine 48 h postoperatively. Laboratory assessments of the graft and creatinine were recorded until 3 months after transplantation besides the post-reperfusion syndrome and the intraoperative hemodynamic measurements.Results: The AKI incidence was comparable between groups (relative risk ratio of 1.285, 95% CI 0.598–2.759, P = 0.518). Moreover, AKI stages and serum creatinine 3 months after transplantation, P = 0.23 and P = 0.25, respectively. The incidence of the post-reperfusion syndrome was comparable in both groups, 29/39 (74.4%) and 31/41 (75.6%) in M and S groups, respectively, P = 0.897. The intraoperative hemodynamic parameters showed no significant difference between groups using the area under the curve.Conclusion: The 1 g/kg mannitol infusion in the pre-reperfusion period did not reduce the risk of early AKI or post-reperfusion syndrome.Clinical trial registration number: Pan African Clinical Trials Registry (PACTR202203622900599)
Gender Rating & Regional Effect on Insurance Price
Authors: Bereketoğlu Abdullah Burkan
Published: August 2022

Even to this day, region and gender in many countries are believed to be one of the most important parameters to measure the pricing or cost of the health insurance that is going to apply to a person. Here in this study, the goal is to analyze causal inferences and effects of the gender and region by bayesian models built to measure the total and direct effect of gender and region. In the end, beliefs of region and gender are important parameters are discussed, and results from a conclusion are given on the case. The use of the PyMC module embedded in the Python programming language is used as the main modeling method.
Potential Novel Therapeutic Targets in Epilepsy from The View of Intestinal Comorbidities
Authors: Jiang Mi , Li Jia , Song Zhi
Published: August 2022

Background: Epilepsy is a complicated neurological disorder with almost 30% refractory. Recent years, several studies showed that epilepsy is associated with its comorbidities by shared molecular mechanisms. However, the association of epilepsy and digestive comorbidities are still unclear. In this study, we aim to explore the association between inflammatory bowel disease (IBD) and epilepsy, and to find promising therapeutic targets for refractory epilepsy. Methods: Two gene expression profiles (GSE134697 and GSE59071) were selected from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified by GEO2R and the DESeq2 package. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of intersection DEGs and Gene Set Enrichment Analysis (GSEA) were conducted by clusterProfiler package. The protein-protein interactions (PPI) network was established by using STRING and visualized by Cytoscape. Genes in the most significant module identified by MCODE plug-in were considered as candidate hub genes. Validation of hub genes were performed by using the GSE143272 dataset. Results: CXCL8, CXCR4 and ITGAX were identified as the hub genes. Conclusions: CXCL8, CXCR4 and ITGAX were the shared molecular mechanism of epilepsy and IBD, which were potentially novel therapeutic targets in epilepsy.
Soil Quality Enhancement with Orchard Age in Pecan Orchards of the Southeastern U.S. Coastal Plain
Authors: Slade Hunter , Wells Lenny
Published: August 2022

Pecan (Carya illinoinensis) orchards in Georgia and throughout the southeastern United States are commonly established from land that had previously been used for row cropping systems. Soil quality is characteristically low in the loamy-sand, low pH soils of the southeastern Coastal Plain. Changes in land use are known to exhibit different effects on soil quality; however, no studies specifically address soil enhancement from converting row crop land to pecan orchards in this region. Sampling was conducted in eight counties throughout the coastal plain of South Georgia in 2020 and 2021. The objectives of this study were to analyze and compare soil quality indicators of pecan orchards of varying ages and adjacent row crop fields. Soil quality indicators analyzed include soil organic matter (SOM), active carbon or permanganate oxidizable carbon (POXC), aggregate stability, cation exchange capacity (CEC), bulk density, porosity, Solvita CO2-Burst, SLAN (Solvita labile-amino nitrogen), pH, and total N. Results from this study demonstrate that pecan orchards under commercial management had higher soil quality compared with row crop fields based on the indicators measured. Active carbon and Solvita CO2-Burst measurements suggest that pecan orchards exhibited significantly higher rates of microbial activity and soil respiration. Indicators of soil microbial activity such as active carbon and Solvita CO2-Burst were strongly correlated with SOM, which explained much of the variation observed in these measurements of soil microbial activity. Selected soil quality indicators also provide evidence that the soil quality of commercial pecan orchards in this region improves with orchard age.
Thidiazuron‐Induced Tissue Culture Regeneration from Quartered‐Seed Explants of Arachis Paraguariensis
Authors: Aina Olubunmi , Quesenberry Kenneth , Gallo Maria
Published: August 2022

Arachis paraguariensis Chodat & Hassl. is a potential source of novel genes for the genetic improvement of cultivated peanut (Arachis hypogaea L.) because some of its accessions show high levels of resistance to early leaf spot caused by Cercospora arachidicola Hori. In this study, induction of high frequency shoot regeneration from quartered‐seed explants was accomplished for six plant introductions of A. paraguariensis under continuous light on Murashige and Skoog (MS) medium containing 4.4 mg L−1 thidiazuron (TDZ) in combination with 2.2 mg L−1 6‐γ‐γ‐(dimethylallylamino)‐purine (2ip). Recovery of a moderately high number of plantlets per quarter seed cultured was also achieved on medium containing 4.4 mg L−1 thidiazuron in combination with 1.1 to 4.4 mg L−1 6‐benzylaminopurine (BAP) with bud formation occurring as early as 1 wk after culture initiation. There were no differences in seed production or in early leaf spot incidence between plants of two genotypes of A. paraguariensis derived from seeds vs. in vitro tissue culture derived plants; however, cultivated peanut cv. Florunner had a higher incidence of early leaf spot.
Oscillations in Modified Combinants of Hadronic Multiplicity Distributions
Authors: Agarwal Pulkit , Ang H. W. , Ong Z. , Chan A. H. , Oh C. H.
Published: August 2022

Oscillations in modified combinants (C_jCjs)
have been of interest to multiparticle production mechanisms since the
1990s [1]. Recently, there has been a discussion on how these
oscillations can be reproduced by compounding a binomial distribution
with a negative binomial distribution [2,3]. In this work, we explore a
stochastic branching model based on a simple interaction term
\lambda\overline{\psi}\phi\psiλψ¯ϕψ
for partons and propose a hadronization scheme to arrive at the final
multiplicity distribution. We study the effects that compounding our
model with a binomial distribution has on C_jCjs
and explore its physical implications. We find that there is a
significant difference in the oscillations in
C_jCjs
between high energy pp and p\bar{p}pp‾
scattering that our model can reproduce.
Transverse Momentum Dependent and collinear densities based on Parton Branching method
Authors: Taheri Monfared Sara , Jung Hannes
Published: August 2022

We review the current status of collinear and Transverse Momentum Dependent densities based on the Parton Branching method. We investigate the performance of the PB-TMD evolution as well as PB-TMD parton shower with different configurations of the hard process in the four- and five-flavour schemes.
Phenomenological study on correlation between flow harmonics and mean transverse momentum in nuclear collisions
Authors: Zhang Chunjian , Jia Jiangyong , Huang Shengli
Published: August 2022

To assess the properties of the quark-gluon plasma formed in nuclear
collisions, the Pearson correlation coefficient between flow harmonics
and mean transverse momentum, \rho\left(v_{n}^{2},\left[p_{\mathrm{T}}\right]\right)ρ(vn2,[pT]),
reflecting the overlapped geometry of colliding atomic nuclei, is
measured. \rho\left(v_{2}^{2},\left[p_{\mathrm{T}}\right]\right)ρ(v22,[pT])
was found to be particularly sensitive to the quadrupole deformation of
the nuclei. We study the influence of the nuclear quadrupole deformation
on \rho\left(v_{n}^{2},\left[p_{\mathrm{T}}\right]\right)ρ(vn2,[pT])
in Au+Au and U+U collisions at RHIC energy using AMPT transport model,
and show that the \rho\left(v_{2}^{2},\left[p_{\mathrm{T}}\right]\right)ρ(v22,[pT])
is reduced by the quadrupole deformation \beta_2β2
and turns to change sign in ultra-central collisions (UCC).
Lund jet plane for Higgs tagging
Authors: Khosa Charanjit Kaur
Published: August 2022

We study the boosted Higgs tagging using the Lund jet plane. The
convolutional neural network is used for the Lund images data set to
classify hadronically decaying Higgs from the QCD background. We
consider H\to b \bar{b}H→bb‾
and H \to ggH→gg
decay for moderate and high Higgs transverse momentum and compare the
performance with the cut based approach using the jet color ring
observable. The approach using Lund plane images provides good tagging
efficiency for all the cases.
Searches for new physics in collision events using a statistical technique for anomaly detection
Authors: Chekanov Sergei
Published: August 2022

This paper discusses a statistical anomaly-detection method for model-independent searches
for new physics in collision events produced at the Large Hadron Collider (LHC).
The method requires calculations of Z-scores for a large number of Lorenz-invariant variables to
identify events that deviate from those expected for the Standard Model (SM).
The importance of multiple scatterings in medium-induced gluon radiation
Authors: Andres Carlota , Dominguez Fabio , Gonzalez Martinez Marcos
Published: August 2022

In this work we disentangle the underlying physical picture of the in-medium gluon radiation process across its different energy regimes by comparing
the recently obtained fully-resummed - without any further approximations - BDMPS-Z in-medium emission spectrum with the extensively used analytical approaches. We observe that in the high-energy regime the radiation process is dominated by a single hard scattering, while in the intermediate-energy region coherence effects among multiple scatterings are crucial. Finally, we prove that in the low-energy regime the dynamics is again controlled by a single scattering but where one must include a suppression factor accounting for the probability of not having any further scatterings.
Study of $\text{D}^0$ meson interactions via femtoscopic correlations
Authors: Maietto Silvério Isabela , Padula Sandra S. , Krein Gastão I.
Published: August 2022

Femtoscopy is a powerful tool that can be used to investigate the
space-time dimensions of the region from which the particles are
emitted. When applied to high energy collisions this method is sensitive
not only to quantum statistics, but also to final state interactions,
such as strong interactions between hadrons and Coulomb interactions
when considering charged particles. In particular, this procedure is
used here to investigate the sensitivity of strong interactions to
different source sizes by considering correlations of
\textrm{D}^{0}D0
mesons, for which no theoretical or experimental results were known so
far.
Recent jet and jet substructure measurements at the LHC, and ML based tagging
Authors: Meena Meena
Published: August 2022

Recent jet and jet substructure measurements at the LHC, and of machine-learning-based tagging techniques are presented using proton-proton collision data collected by the ATLAS and CMS experiments at CERN's Large Hadron Collider. These measurements are crucial for precise tests of electroweak and pQCD calculations and searches for physics beyond the Standard Model. The measurements are compared with several Monte Carlo event generators predictions which provide valuable input to the tuning of perturbative and non-perturbative models and to constraining model parameters of advanced parton-shower Monte Carlo programs.
SOIL SERIES CHARACTERISTICS AVAILABLE NUTRIENTS AND YIELD IN THE SOILS OF BARAGAON BLOCK DISTRICT VARANASI (UTTAR PRADESH.)
Authors:   National Bureau of Soil Survey and Land Use Planning, Regional Centre Delhi- 110012., Singh Dharam , a Vikas ,   National Bureau of Soil Survey and Land Use Planning, Regional Centre Delhi- 110012., Verma T.P. ,   National Bureau of Soil Survey and Land Use Planning, Regional Centre Delhi- 110012., N. Surya Jaya ,   National Bureau of Soil Survey and Land Use Planning, Regional Centre Delhi- 110012., Yadav R.P. ,   National Bureau of Soil Survey and Land Use Planning, Regional Centre Delhi- 110012., Singh S.K. ,   National Bureau of Soil Survey and Land Use Planning, Regional Centre Delhi- 110012.
Published: August 2022

Soils are finite, precious and resources are shrinking. The nutrients control the productivity from the soils and manage the yields of crops. The Baragaon block of district Varanasi was selected for Land Resource Inventory on 1:10000 Scales for optimal Agricultural Land Use Planning using geospatial techniques. Seven soils series were identified and Soil profile samples were collected and analyzed in laboratory for pH, EC, OC, Caco3, N, P, K, and micronutrients Zn, Cu, Fe and Mn. Soil samples were found low in organic carbon, available nitrogen and phosphorus while medium and high in potassium. All samples were found deficient in available sulphur. Significant positive correlations were found to exist between organic carbon and available N, P, K and S status in soil series of Baragaon Block of Varanasi district, Uttar Pradesh.
BLEPHAROPLASTY : INDICATIONS AND SURGICAL TECHNIQUES
Authors:   Assistant Professor and Head of the Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Adil Dehhaze , Sara Tita ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Mouad Echmili ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Hanae Tazi ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Nada-Imane Daghouri ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Rim Labbaci ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Othmane Taibi ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Issam Diher ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco.
Published: August 2022

Blepharoplasty consists of surgically removing eyelid skin excess or fat protrusion along the eyelid crease mostly for improved cosmesis or for therapeutic purposes .Attaining successful outcomes relies on a solid understanding of facial topography,indications, patient and technique selection. Our study, made in the department ofPlastic , Reconstructive and Aesthetic Surgery , Center of burned patients of the University Hospital of Tangier-Tetouan-Alhouceima 01/03/2021 to 20/05/2022 is about 21 cases of upper blepharoplasty , mostly in middle aged women , in response to a dermatochalasis and only one in a male patient presenting ptosis. In this work , we discuss the noted results from the study with a wide range of background literature in the eye-face rejuvenation surgery.