bluuebunny/crossref_metadata_2025 huggingface dataset:
I think they should give primary health care a little more priority. The Primary Health Care in Caribbean SIDS: What can be said about adaptation to the changing climate? The case of Dominica. A qualitative study
Authors: Harris-Glenville Fiona , Cloos Patrick
Published: July 2023

Background
Climate change (CC) adaptation is considered a priority for Caribbean Small Islands Developing States (SIDS), as these territories and communities are considered particularly vulnerable to climate-related events. The primary health care (PHC) system is an important actor in contributing to climate change adaptation. However, knowledge on how PHC is prepared for CC in Caribbean SIDS is very limited. The objective of this paper is to discuss health adaptation to climate change focusing on the PHC system.
Methods
We explored the perspectives of PHC professionals in Dominica on climate change. Focus group discussions (FGDs) were conducted in each of the seven health districts in Dominica, a Caribbean SIDS, between November 2021 and January 2022. The semi-structured interview guide was based on the Essential Public Health Functions: assessment, access to health care services, policy development and resource allocation. Data coding was organized accordingly.
Results
Findings suggest that health care providers perceive climate change as contributing to an increase in NCDs and mental health problems. Climate-related events create barriers to care and exacerbate the chronic deficiencies within the health system, especially in the absence of high-level policy support. Healthcare providers need to take a holistic view of health and act accordingly in terms of disease prevention and health promotion, epidemiological surveillance, and ensuring the widest possible access to health care, with a particular focus on the ecological and social determinants of vulnerability.
Conclusion
The Primary Health Care system should be a key actor in designing and operationalizing adaptation and transformative resilience. The Essential Public Health Functions should integrate social and climate and ecological determinants of health to guide primary care activities to protect the health of communities. This indicates a need for improved research on the linkages between climate events and health outcomes, surveillance, and development of plans that are guided by contextual knowledge in the SIDS.
Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
Authors: Pecci Valeria , Troisi Fabiola , Aiello Aurora , De Martino Sara , Carlino Angela , Fiorentino Vincenzo , Ripoli Cristian , Rotili Dante , Pierconti Francesco , Martini Maurizio , Porru Manuela , Pinto Francesco , Mai Antonello , Bassi Pier Francesco , Grassi Claudio , Gaetano Carlo , Pontecorvi Alfredo , Strigari Lidia , Farsetti Antonella , Nanni Simona
Published: July 2023

Background
About 30% of Prostate cancer (PCa) patients progress to metastatic PCa that remains largely incurable. This evidence underlines the need for the development of innovative therapies. In this direction, the potential research focus might be on long non-coding RNAs (lncRNAs) like H19, which serve critical biological functions and show significant dysregulation in cancer. Previously, it has been shown that the long noncoding RNA H19 acts as transcriptional repressor of cell adhesion molecules affecting the PCa metastatic potential. Here, we investigated the role of H19/cell adhesion molecules circuitry on in vivo PCa experimental tumor growth and metastatic dissemination models.
Methods
H19 was silenced in luciferase-positive PC-3 and 22Rv1 cells and in vitro effect was evaluated by gene expression, proliferation, invasion and colony formation assays before and after treatment with the histone lysine demethylase inhibitor, GSK-J4. In vivo tumor growth and metastasis dissemination, in the presence or absence of GSK-J4, were analyzed in two models of human tumor in immunodeficient mice by in vivo bioluminescent imaging and immunohistochemistry (IHC) on explanted tissues. Organotypic Slice Cultures (OSCs) from fresh PCa-explant were used as ex vivo model to test GSK-J4 effects. Analysis of H19/cell adhesion molecules circuitry on PCa biopsies was conducted by IHC and droplet digital PCR on Formalin-Fixed Paraffin-Embedded tissues.
Results
H19 silencing in both PC-3 and 22Rv1 cells increased: i) E-cadherin and β4 integrin expression as well as invasion and colony formation, ii) in vivo tumor growth, and iii) metastasis formation at bone, lung, and liver. Of note, treatment with GSK-J4 reduced lesions. In parallel, GSK-J4 efficiently induced cell death in PCa-derived OSCs. Lastly, we investigated the potential of early predicting disease progression of the H19/cell adhesion molecules circuitry evaluated at the time of biopsy.
Conclusions
Our findings underscore the potential of the H19/cell adhesion molecules circuitry as a targeted approach in PCa treatment. Modulating this interaction has proven effective in inhibiting tumor growth and metastasis, presenting a logical foundation for targeted therapy. Additionally, the predictive potential of the H19/cell adhesion molecules circuitry suggests the possibility of an early application in PCa management.
The role of tumor-associated macrophages in the radioresistance of esophageal cancer cells via regulation of the VEGF-mediated angiogenic pathway
Authors: Sun Fei , Lian Yingying , Zhou Mengyun , Luo Judong , Hu Lijun , Wang Jianlin , Zhiqiang Sun , Yu Jingping
Published: July 2023

Tumor-associated macrophages (TAMs) are known to promote tumor growth, invasion, metastasis, and protumor angiogenesis, but the role of TAMs in the radiotherapy of esophagus cancer remains unclear. In this study, we first induced TAMs from human monocytes (THP-1) and identified using immunofluorescence and Western blotting assays. We then co-cultured them with human esophageal cancer cell lines. CCK-8, colony formation, Transwell, scratch test, and TUNEL assays showed that TAMs could promote proliferation, survival rate, invasion, migration, and radio-resistance and could inhibit apoptosis of the esophageal squamous carcinoma cell lines KYSE-150 and TE-1 before and after radiotherapy both in vivo and in vitro. Using LV-VEGFA-RNAi lentiviral vectors, we also found that TAMs could increase the expression of VEGFA and that inhibition of VEGFA could inhibit the biological function caused by TAMs. Finally, a Western blotting assay was used to evaluate the expression of various factors underlying the mechanism of TAMs. VEGFA, MAPK, P-MAPK, BCL-2, and Snail proteins were found to be overexpressed in co-cultured groups, whereas after VEGFA inhibition, MAPK, P-MAPK, BCL-2, and Snail proteins were found to be significantly down-regulated in the radiotherapy group. These study results offer important information regarding the mechanism of radio-resistance in esophageal cancer.
AQP3 influences the development of recurrent spontaneous abortion by regulating trophoblast proliferation and migration via the AQP3/IGF2BP1/PI3K/AKT signaling pathway
Authors: Nong Yingqi , Wei Jiahui , Liu Wenjuan , Wang Fang , Li Zitao , Liu Dun , Wang Zhaoyi , Liang Xiangping , Zhang Xiqian , Liu Fenghua
Published: July 2023

Background
Reduced trophoblast migration and invasion contributes markedly to recurrent spontaneous abortion (RSA). Aquaporin 3 (AQP3) is a key protein necessary for trophoblast migration and invasion in the fetal–maternal crosstalk during early pregnancy. However, the involvement of AQP3 in RSA remains unknown. Here, the molecular mechanisms acting upstream and downstream of AQP3 and modulatory effects on trophoblast migration and invasion were examined.
Methods
AQP3 expression was detected in the villi of patients with RSA. The molecular mechanisms whereby AQP3 regulates the migration and invasion of human extravillous trophoblasts (HTR-8/SVneo cells), including the role of the PI3K/AKT signaling pathway and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), were investigated.
Results
AQP3 expression was lower in the villi of patients with RSA than in the controls. Key PI3K/AKT signaling pathway kinase expression levels were elevated after AQP3 overexpression (OE); the opposite effects occurred after AQP3 knockdown. PI3K/AKT signaling inhibition by LY294002 partially reversed trophoblast migration and invasion and AQP3 OE-mediated PI3K/AKT activation. IGF2BP1 knockdown reduced AQP3 mRNA stability and impaired trophoblast migration and invasion; IGF2BP1 OE exerted the opposite effects. AQP3 mRNA bound to the IGF2BP1 protein, and the m6A-modified AQP3 was significantly enriched in HTR-8/SVneo cells.
Conclusions
IGF2BP1 detects and binds to AQP3 mRNA, enhancing its stability and activating the PI3K/AKT pathway, thereby affecting the migration and invasion of HTR-8/SVneo cells. These findings indicate a new fundamental mechanism for treating RSA.
Synthesis, anticancer, antioxidant activities and in silico studies of novel benzhydrylpiperazine bearing Δ 2 -1,2,3-triazoline hydrides
Authors: Al-Masoudi Najim A. , Jihad Raad S. , Abdul-Rida Nabeel A. , Al-Shamari Amer M. J. , Saeed Bahjat , Al-Masoudi Wasfi A.
Published: July 2023

To investigate the antiproliferative activity associated with the piperazine framework, a series of benzhydryl piperazine derivatives 8–18 were synthesized and characterized both spectroscopically and structurally. The antiproliferative activity of these compounds against eight human tumor cell lines was assessed. Among the tested compounds, compound 11 exhibited the highest potency, effectively inhibiting the proliferation of three selected human cancer cell lines, HL-60, Z138, and DND-41 with IC50 values of 16.80, 18.50 and 19.20 µM, respectively. Compound 10 displayed IC50 values of 19.90, 18.00 and 18.50 µM against the cell lines HL-60, Z138 and DND-41, whereas compound 13 showed IC50 value of 19.90 µM against cell line DND-41. However, all compounds exhibited IC50 values ranging from 22.95 and 58.45 µM against other tested cancer cell lines. These finding suggest that derivative 11 would be a promising potential lead compound for the development of novel antiproliferative agents. Further compounds 8–18 were evaluated for their antioxidant activity. Additionally, predictive docking studies were performed on the three-dimensional structures of acute myeloid leukemia (CDK2/cyclin A2, PDB: 7B7S, and protein kinase Akt1 PKB alpha, PDB: 4GV1).
Autonomous Vehicle Detection and Tracking Based on Improved Yolov5 and Gmmpf in Harsh Weather Conditions
Authors: Vellaidurai Arthi , Rathinam Murugeswari
Published: July 2023

Autonomous vehicles (AVs) rely on various sensory data to accurately understand their surroundings and guarantee a safe voyage. In AVs, and intelligent transportation systems, vehicle detection and tracking (VDT) are crucial. A camera's ability to perform is dangerously restricted by adverse or challenging weather conditions (CWC) like fog, rain, snow, sandstorms or dust, which all compromise driving safety by lowering visibility. These limitations affect how well the identification and tracking models used in traffic surveillance systems as well as applications for AVs function. This paper proposes autonomous VDT system using Improved You Look Only Once Version 5 (IYOLOV5) and Particle Filter based on a Gaussian Mixture Model (GMMPF) in harsh weather conditions. This paper consists of four steps: image collection, image deweathering, vehicle detection, and vehicle tracking (VT). First, the multiple roadside vehicles are collected from the datasets. Next, image deweathering is performed based on the Adaptive Automatic White balance (AAWB) method, which improves the quality of the images and preserves the edge details. Next, the IYOLOV5 algorithm is used to detect the vehicle, and finally, the vehicles are tracked using the GMMPF concept. The suggested method is evaluated and contrasted with the current methods on the DAWN and COCO datasets. The outcomes have confirmed the usefulness of the suggested solution, which outperforms cutting-edge vehicle recognition and tracking techniques in inclement weather.
Association of APOE polymorphisms with serological lipid and inflammatory markers
Authors: Krishnamurthy Hari Krishnan , Rajavelu Imbaasree , Reddy Swarnkumar , Pereira Michelle , Jayaraman Vasanth , Krishna Karthik , Song Qi , Wang Tianhao , Bei Kang , Rajasekaran John J.
Published: July 2023

Background
The study aims to assess the association of apolipoprotein E (APOE) gene polymorphisms with serological lipid and inflammatory markers to determine their potential role in predicting the risk of cardiovascular diseases (CVD) and Alzheimer's disease (AD).
Methods
A total of 915 individuals underwent testing for lipid and inflammatory biomarkers at Vibrant America Clinical Laboratory. Clinical data, blood lipid and inflammatory profiles, and APOE genotyping were analyzed using PCR-RFLP.
Result
Compared to the E3/E3 genotype, individuals with E2/E3 genotypes showed higher levels of HDL, triglycerides, APOA, HSCRP, and MPO. E2/E4 genotype carriers had higher levels of HDL, triglycerides, Lp(a), and BNPNT. E3/E4 genotypes were associated with elevated levels of total cholesterol, LDL, Lp(a), HSCRP, SDLDL, OXLDL, MPO, LDL-CAL, PLAC, and APOB. The E4/E4 group displayed higher concentrations of total cholesterol, LDL cholesterol, APOB, Lp(a), HSCRP, SDLDL, OXLDL, MPO, LDLCAL, and PLAC compared to E3/E3 carriers. These findings highlight the atherogenic effect of the ε4 allele and the potential protective effect of the ε2 allele on lipid and inflammatory markers.
Conclusion
This study provides strong evidence linking APOE gene polymorphism to abnormal serum lipid and inflammatory profiles. Individuals carrying the e4 alleles exhibited dysregulated lipid metabolism and abnormal inflammatory markers, increasing their risk of CVD and AD. Early detection and prompt diagnosis are crucial for implementing therapeutic, dietary, and lifestyle interventions to mitigate risks and prevent or delay lipid and inflammation-related disorders.
Pure Total Flavonoids From Citrus Ameliorate NSAIDs-Induced Intestinal Mucosal Injury via Regulation of Exosomal LncRNA H19 Expression
Authors: Chen Shanshan , He Ruonan , Li Ying , Zhang Shuo
Published: July 2023

Non-steroid anti-inflammatory drugs (NSAIDs) are widely used in the clinic because of their excellent antipyretic, anti-inflammatory, and analgesic effects. However, long-term use of NSAIDs will disrupt the intestinal mucosal barrier, causing erosion, ulcers, bleeding, and even perforation. How to balance the use and side effects of NSAIDs is an urgent clinical problem. Elucidating the mechanism related to disrupting the intestinal mucosal barrier caused by NSAIDs and achieving targeted drug prevention or treatment is the key. In the study, we investigated the mechanism of exosomal lncRNA H19 in the intestinal mucosal barrier injury associated with NSAIDs and the intervention of pure total flavonoids from Citrus (PTFC). Results showed that IEC-6 cells co-cultured with NSAIDs rats-derived exosomes possessed the lowest protective autophagy levels and intestinal mucosal mechanical barrier function disturbance. By contrast, though the IEC-6 cells co-cultured with the exosomes extracted from rats receiving early prevention with PTFC still exhibited a certain inhibition of autophagy and disturbance of intestinal mucosal mechanical barrier function, both were significantly better. The prevention effect was proportional to the concentration of PTFC administered. Exosomal lncRNA H19 is the critical RNA in the above mechanism, which regulates protective autophagy and intestinal mucosal mechanical barrier function.
Low molecular weight peptides derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Authors: Alikhani Hani Keshavarz , Zargan Jamil , Bidmeshkipour Ali , Naghneh Ehsan , Hajinoormohammadi Ashkan , Zamani Ehsan
Published: July 2023

Background
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. Natural compounds, such as venom-derived peptides, have emerged as potential sources of anticancer agents. 3D cell models, which closely resemble the architectural characteristics of natural tumors, serve as an appropriate system for investigating the cytotoxic and apoptotic effects of scorpion venom on cancer cells. In this study, we investigated the apoptotic effects of low molecular weight peptides isolated from the venom of Odontobuthus bidentatus on HepG2 cells in a 3D cell culture model.
Methods and Results
The O. bidentatus venom was subjected to high-performance liquid chromatography (HPLC) for fractionation and purification of the low molecular weight peptides. Subsequently, the isolated peptides were evaluated for their impact on cell viability and apoptosis induction in HepG2 cells within a 3D cell culture system and were compared to crude venom. To create a 3D cell culture, HepG2 cells were enclosed within alginate hydrogel. Subsequently, the cytotoxic effects of scorpion venom were evaluated using MTT and neutral red uptake assays. Changes in the redox potential of HepG2 cells were assessed by measuring accumulated nitric oxide (NO) in the cell culture media, as well as levels of glutathione (GSH) and catalase activity. To determine the induction of apoptosis in cells treated with scorpion venom, various assays including alkaline comet assay, caspase-3 enzyme activity, and cytochrome c release were employed. Additionally, the expression of the pro-apoptotic gene BAX and the anti-apoptotic gene BCL-2 was evaluated using qRT-PCR. The results obtained from the MTT and neutral red uptake assays demonstrated that O. bidentatus crude venom and isolated fractions (5, 6, and 10) had cytotoxic effects on HepG2 cells in the 3D cell culture. The concentration of NO released into the culture media increased, while the levels of reduced glutathione and catalase decreased in a dose-dependent manner within the 3D culture. The findings from the caspase-3 enzyme activity, cytochrome c release assay, comet assay, and Bax/Bcl-2 gene expression ratio supported the conclusion that O. bidentatus scorpion venom induces apoptosis through the mitochondrial pathway.
Conclusion
This finding highlights the potential of scorpion venom-derived peptides as novel therapeutic agents for hepatocellular carcinoma.
Enhancing display resolution through virtual pixel creation: a software-based approach for existing displays
Authors: Carmona-Ballester David , Bonaque-González Sergio , Trujillo-Sevilla Juan M. , Ceruso Sabato , Rodríguez-Ramos José M.
Published: July 2023

The increasing demand for high-resolution displays has spurred advancements in pixel density; however, certain applications, such as head-mounted displays (HMDs) and image projectors, still suffer from noticeable pixel structures that degrade user experience. Conventional methods of resolution enhancement are often complex and costly, limiting their practicality. To address this, we propose a software-based methodology for improving screen resolution through controlled optical defocus. This method introduces a blur into the system, generating overlapping virtual pixels in the image space. The original image is pre-compensated, considering the altered intensity distribution caused by these virtual pixels. Consequently, the displayed image is perceived as having higher resolution than the native display. We present the mathematical foundations of this methodology, which were validated through computational analysis and real-world implementations on HMDs and projectors. The proposed approach distinguishes itself from previous works on overlapping sub-frames by requiring only a single display and a single optical element, offering a simpler and more cost-effective solution. Experimental results demonstrate a significant reduction in the screen-door effect for HMDs and an enhanced resolution for projectors, with minimal loss of quality, particularly in contrast. The findings highlight the potential of our approach to open new avenues for the development of these technologies. By providing a practical and effective means of resolution improvement, our methodology holds promise for addressing the challenges associated with pixel structures in various display applications.
Lactate gene signature based on mitophagy predict the prognosis and immune response in lung adenocarcinoma
Authors: Jiang Wenjie , Zhang Fan , Shang Pan , Xu Shuonan , Zhang Yukun , Jiang Tao , Zhong Daixing
Published: July 2023

Background
Lung adenocarcinoma (LUAD) causes leading death worldwide. Mitophagy and release of lactate is critical feature in tumor environment. We aimed to identified a mitophagy relate lactate related gene (LRG) signature for predicting prognosis and immune response in LUAD.
Methods
The gene expression and clinical data were downloaded from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. Firstly, according to the 29 mitophagy genes from Pathway Unification database, the subtype analysis analyzed using ConsensusClusterP lus. Survival, clinical, immune, and function differences between the two subtypes were analyzed. Then, based on the mitophagy genes and 14 LRGs from MSigDBv7.5.1 database, weighed gene co-expression network analysis (WGCNA) and univariate cox analysis were used to screen the optimal LRGs genes. A risk score model was established based on the optimal LRGs genes. Survival, mutation, drug sensitivity, and immune feature between high- and low-risk groups were also analyzed. Furthermore, the distribution of risk score indifferent subtypes were also explored. Finally, based on the risk score and clinical factors, a nomogram for predicting the patient survival were established.
Results
All the LUAD samples were divided into 2 subtypes: sub 1 and sub 2. Sub 2 possessed worse survival (P < 0.05). Immune score, immune checkpoint genes, human leucocyte antigen genes in sub2 were higher than in sub 1, suggesting an active immune microenvironment in sub 2. Six optimal mitophagy-related LRGs (LDHA, PLEC, DARS2, ACAT1, C1QBP, and OGDH) were used to construct a risk score model and the model was effective in predicting the survival of LUAD patients. High-risk score indicates a poorer survival, higher tumor mutation burden, and higher drug sensitivity. Furthermore, sub 2 contained more high-risk samples, further demonstrating the predicting ability of the subtypes and risk score groups. Finally, nomogram was also robust in predicting LUAD survival with AUC more than 0.7.
Conclusion
These results are useful for prognosis of survival and immune status, as well as provide indication for patient drug option in LUAD.
Android Malware Detection using LSTM with Smali Codes
Authors: Anand Abhishek , Singh Jyoti Prakash , Khan Rida Sohail , Kumari Anjali , Mishra Divya
Published: July 2023

With the widespread adoption of smartphones and the rapid growth of the mobile Internet, the Android platform has become highly popular. However, its open-source nature has also made it susceptible to rampant malware attacks. In light of this, this research paper proposes a malware detection system based on Smali-LSTM to enhance the efficiency of malware detection on the Android platform. The detection system employs a static analysis approach to extract Smali files from applications. These extracted Smali files undergo a series of preprocessing steps to extract relevant features. To ensure compatibility with the LSTM model, the preprocessed Smali files are fragmented into smaller pieces. The paper explores and tests fragments of various sizes to identify the optimal configuration that yields the best results. The findings of the study demonstrate that the proposed Smali-LSTM model outperforms existing works that utilize the same dataset and LSTM model. The achieved results showcase an accuracy of 96.58\% and an impressive precision of 100\%. These outcomes validate the effectiveness and superiority of the proposed model in accurately detecting malware in Android applications.
LAPTM4B-35 promotes the progression of salivary gland mucoepidermoid carcinoma
Authors: Liu Wei , Guan Jiaying , Qi Xiaofeng , Yang Jiaxin , Fan Jianlin
Published: July 2023

Mucoepidermoid carcinoma (MEC) is the most common type of malignancy affecting the salivary glands. Previous studies have suggested the involvement of lysosome-associated transmembrane protein 4β (LAPTM4B) in the development and progression of various tumors. However, its specific role in MEC has not been fully elucidated. In this study, we aimed to investigate the expression of LAPTM4B-35 in MEC tissue samples and explore its association with clinicopathological features. Additionally, we sought to inhibit the expression of LAPTM4B-35 in an MEC cell line and assess its impact on proliferation, invasion, apoptosis, and cell cycle. Our findings revealed upregulated expression of LAPTM4B-35 protein in MEC tissues. Furthermore, we observed that LAPTM4B-35 overexpression correlated with high histological grade and advanced clinical stages in MEC patients. To determine the functional significance of LAPTM4B-35, we performed knockdown experiments in MEC cells, which resulted in reduced proliferation and invasion ability, increased apoptosis rates, and altered cell cycle distribution. Taken together, these results suggest that LAPTM4B-35 may play a crucial role in the development of MEC and could potentially serve as a target for individualized therapy.
No Cozy Catastrophe: A Critique of Technological Civilization in John Wyndham’s The Day of the Triffids
Authors:   British And American Language And Literature Association Of Korea, Kim Younghee
Published: July 2023

This study investigates John Wyndham’s The Day of the Triffids(1951), an iconic piece of post-apocalyptic literature, by focusing on the array of disasters portrayed within the narrative. It explores the inversion of established dominance-subordination dynamics stemming from a botanical retaliation and humanity’s downfall due to unbridled greed and uncritical trust in technology. The analysis delves deeper into the circumstances leading to widespread human blindness triggered by malfunctioning artificial satellites armed with chemical weapons. This event displaces humans from their position as nature’s exploiters, thereby overturning the nature-human relationship. Further, the study illuminates how Triffids, carnivorous plants resulting from haphazard genetic modification experiments and used to serve capitalist interests, steadily infiltrate England’s sophisticated society, pushing humanity towards extinction. Despite the ‘cozy catastrophe’ tag, The Day of the Triffids is far from comforting, and it graphically communicates the disastrous consequences of human arrogance and blind reliance on technological civilization. This research explores the gradual encroachment of British civilization by the Triffids, scrutinizes the reversal of the nature-human relationship as most of the populace loses sight, and examines how such a fictional disaster can offer realistic societal contemplation.
Literature as Peace Work: Eyes on Kashmira Sheth’s Keeping Corner
Authors:   British And American Language And Literature Association Of Korea, Jocelyn Wright
Published: July 2023

Many works of literature are not conceptualized or recognized and classified as peace literature (PL). Reasons include unfamiliarity with the genre, limited intentional PL writing, and difficulty defining and delimiting it. To increase recognition of PL, this paper sets out to describe the genre and show how literature can be analyzed through a peace lens, focusing on a piece of historical literature for young adults by novelist Kashmira Sheth (2007), Keeping Corner. A close reading informed by a systematic conceptualization of peace shows that the author makes significant choices in the genre, content, and techniques employed to critically and creatively foreground and highlight peace as a transformative process and desirable outcome. In so doing, she contributes to peace in and through literature. This paper concludes faithful to its commitment to the tripartite of education, research, and action for peace, by summarizing, discussing the value of PL, advocating for its development and promotion, and briefly indicating ways of doing so.
Religious Hypocrisy and Dichotomous Frames in The Massacre at Paris
Authors:   British And American Language And Literature Association Of Korea, Kim Taeyoung
Published: July 2023

Dichotomously distinguishing whether Christopher Marlowe's The Massacre at Paris advocates Protestantism makes it difficult to objectively appreciate this play. If we avoid such distinctions and read this work in the general context, we can discover the universal nature and values of human society. The central characters, the French Catholics, in this play justify their distorted desires with their religious beliefs and thoroughly otherize others’ religion in the name of protecting the state and religion. However, this discrimination and oppression occur in the UK in the same way. Both Protestants and Catholics otherize each other only through self-centered judgment. Marlowe looks cynically at both sides who use religion as a tool to maintain their power and achieve distorted desires. Therefore, we had better stop trying to analyze Marlowe’s own religious views in this play. By doing so, we can find that uncontrolled power and distorted ambitions lead to irreversible tragedies. In conclusion, apart from the religious orientation of Marlowe and his work, I will find out the lesson that distorted desires and dichotomous distinctions lead only to tragedy.
Aspects of a Technological Evolution in Where Late the Sweet Birds Sang by Kate Wilhelm
Authors:   British And American Language And Literature Association Of Korea, Ahn Jin-Hung
Published: July 2023

This study analyzes Where Late the Sweet Birds Sang by Kate Wilhelm to reflect on the dominant species’ reaction to the minorities of the society. This novel begins with the last generation of mankind creating clones to prevent their own extinction only to see that their clones become dominant. Accordingly, human society evolves into a cloned human society, which in turn evolves into a hybrid society of humans and clones, evolving solely on technology in a barren world where biological evolution has become impossible. The nature of humanity in itself is the topic of this study. The human community distinguishes non-human from human on the basis of humanity and tends to react negatively to non-humans, considering that the alien factors would threaten their society. Likewise, clones exclude humans when they become dominant, regarding humans as backward creatures. As a political philosopher, Roberto Esposito, insists, the communities respond to foreign material in the same way as the immune system does to a disease or contamination, which can result in autoimmunity that attacks the body and the society. However, what appears to be contamination does not belong to the outside, but already exists inside. Hybridity is a feature of both living and nonliving things including humans. There’s no such thing as humanity.
Stability and asymptotic interactions of chiral magnetic skyrmions in a tilted magnetic field
Authors: Barton-Singer Bruno , Schroers Bernd
Published: July 2023

Using a general framework, interaction potentials between chiral magnetic solitons in a planar system with a tilted external magnetic field are calculated analytically in the limit of large separation. The results are compared to previous numerical results for solitons with topological charge \pm 1±1. A key feature of the calculation is the interpretation of Dzyaloshinskii-Moriya interaction (DMI) as a background SO(3)SO(3) gauge field. In a tilted field, this leads to a U(1)U(1)-gauged version of the usual equation for spin excitations, leading to a distinctive oscillating interaction profile. We also obtain predictions for skyrmion stability in a tilted field which closely match numerical observations.
Fluxos migratórios, hospitalidade e cultura no ambiente cosmopolita
Authors: Squeff Tatiana de Almeida Freitas Rodrigues Cardoso , De Carvalho Victória Magri Moreira , Nunes Julia Abate
Published: July 2023

O presente escrito tem como propósito inicial debater os fluxos migratórios contemporâneos, apontando as suas origens e as suas características centrais, em especial a compreensão do sujeito fundamental desta ação de deslocamento, que é o indivíduo, caracterizando-o não mais como um mero cidadão no mundo, mas como um cidadão do mundo. Isso porque, é a partir dessa construção que o texto propõe uma reflexão acerca da hospitalidade para com os migrantes. Tão necessária na atualidade, essa construção aponta para a necessidade de ser bem recebido em qualquer localidade, independentemente de suas origens, sugerindo a obtenção de diversos ganhos com uma recepção “tranquila”. E ao cabo, indica-se que o Pacto Global para Migrações é uma ferramenta essencial para a efetivação da hospitalidade e das trocas interculturais no ambiente cosmopolita, na medida em que ele visa a ordenar as migrações de todas as regiões do mundo, reduzindo quaisquer tipos de impactos negativos que possam surgir em razão de um influxo exacerbado de pessoas em direção a uma mesma localidade. Para tanto, utilizando-se do método dedutivo de pesquisa, realizou-se um estudo aplicado descritivo e explicativo, baseado em análise doutrinária e documental, coletada qualitativamente.
A justiciabilidade do direito à saúde na corte interamericana de direitos humanos: Uma breve análise jurisprudencial
Authors: Bosa Anderson Carlos , Maas Rosana Helena
Published: July 2023

Tendo em vista a tutela internacional dos direitos humanos, e em virtude da carência de proteção expressa dos direitos econômicos, sociais, culturais e ambientais pela Convenção Americana sobre Direitos Humanos – que prevê, em seu artigo 26, apenas uma proteção progressiva desses direitos –, pretende-se estudar alguns aspectos sobre a justiciabilidade do direito à saúde perante a Corte Interamericana de Direitos Humanos, observando a posição de sua jurisprudência quanto à tutela desse direito. Utiliza-se do método dedutivo e da técnica de pesquisa bibliográfica e jurisprudencial para responder à seguinte problemática: Qual é a posição da Corte Interamericana de Direitos Humanos acerca da proteção e justiciabilidade do direito à saúde? Ao final, observa-se que a sistemática de proteção da Convenção Americana sobre Direitos Humanos, em regra, não permite a justiciabilidade do direito à saúde perante a Corte Interamericana de Direitos Humanos, a qual, inicialmente, tutela o respectivo direito de maneira indireta por intermédio dos direitos civis e políticos, passando, a partir de 2018, a reconhecer sua justiciabilidade direta e autônoma por meio do artigo 26 da Convenção Americana sobre Direitos Humanos. A importância deste trabalho reside no fato de compreender como a proteção dos direitos coletivos se dá em âmbito internacional, o que reflete diretamente no direito interno dos Estados, configurando uma proteção multinível de direitos.
Dye-Sensitized TiO2 as Heterogenous Visible Light Photocatalyst for the Hydroxylation of Aryl Boronic Acids
Authors: Argüello Juan , Heredia Adrián , Bouchet Lydia
Published: July 2023

Herein, we report the preparation of a variety of dye-sensitized TiO2 and its application as a heterogeneous photocatalyst for the oxidative hydroxylation of boronic acids and esters to synthesize phenols. Several organic dyes, namely eosin Y, rose bengal, purpurin, alizarin blue, fluorescein and riboflavin were combined with TiO2. The nanohybrid TiO2-eosin Y showed the best results. Furthermore, we demonstrated a synergistic association between dyes and TiO2 that improves its photocatalytic properties. This methodology resulted compatible for aryl boronic acids with both electron-withdrawing and electron donor groups on the aromatic ring. Thus, the reactions were performed under heterogeneous photocatalytic conditions, employing visible light, saturated oxygen atmosphere, short reaction time, acetonitrile and water as environmentally friendly solvents, to produce the corresponding phenols in very good to excellent isolated yields. Finally, we proposed a mechanism where the selective excitation of EY associated with TiO2 using visible light and the formation of the superoxide anion play a main role in this reaction.
Changes in some physical properties of the soils tread with wheat straw and rice husk under the rotation of white-head cabbage, tomato and wheat
Authors: BAYRAKLİ Betul , GÜLSER Coşkun
Published: July 2023

This study was carried out silty clay (SiC) textured soil and silty land (SiL) textured soil in order to reveal the changes in some physical properties of the soil in white-head cabbage (WHC), tomato (T) and wheat (W) rotation after the application of wheat straw (WS) and rice husk (RH). Soil organic matter (OM), bulk density (BD), total porosity (F), aggregate stability (AS), mean weight diameter (MWD), field capacity (FC), volumetric water content (Ɵ), penetration resistance (PR), relative saturation (RS) and initial infiltration (In) values were determined, after harvest of each plant. As the results of the experiments pointed out, soil OM contents and F values increased, while BD values decreased after WHC, T and W harvest with WS and RH application. With a higher C/N ratio, WS application increased soil OM content more than RH application. The lowest BD, AS, and MWD values were generally obtained after the WHC and T harvest, and the highest BD, AS, PR and in values after the W harvest. Soil OM content showed very significant negative relationships with BD (-0.561**), MWD (-0.680**) and RS (-0.528**) in the silty clay (SiC) textured soils, while it showed very significant negative relationships with BD (-0.809**), AS (-0.543**), MWD (-0.830**), PR (-0.555**) and very significant positive relationships with FC (0.728**), Ɵ (0.814**), RS (0.767**) in the silty loam (SiL) textured soils.
Discovering spatio-temporal dependencies in mangrove forest change: evidence from northwestern Asian communities
Authors: Forouzannia Mojtaba , Chamani Atefeh
Published: July 2023

The Iranian southern intertidal ecosystems are colonized by mangrove forests (mostly Avicennia marina) and presented a notable mangrove area expansion over the past decades. To discover its spatio-temporal dependencies, five mangrove forests were studied along a coastline of more than 1,200 km. Cloud-free Landsat images were processed using a temporal median filter to produce one representative Landsat image for each year from 1988 to 2020. The images were categorized into mangrove and non-mangrove classes using an object-based algorithm and visual post-classification. A consistent mangrove area expansion was observed across all regions, which regressed linearly against time with an adjusted R2 range of 0.914–0.955 (p < 0.01). The expansions were also found to be highly significantly similar (0.182 < p < 0.822) using the t-test applied on the slope of region-specific regression models. Three spatial metrics of infilling, edge-expansion, and outlying were developed to investigate the spatial pattern of expansions. Results showed the dominance of the edge-expansion pattern across all regions (53–78% of the expansions), which was attributed to the better establishment of propagules near and under the canopy of parent trees. The outlying pattern (11–22%) was related to mangrove colonization along the inland creeks.
Overview of the Treatment of Congestion in Heart Failure
Authors: Martinez-Sole Julia , Sanchez-Martinez Jose Carlos , Lopez-Vilella Raquel , Donoso-Trenado Victor , Sanchez-Lazaro Ignacio , Almenar-Bonet Luis , Sanz-Sanchez Jorge , Martinez-Dolz Luis
Published: July 2023

Heart failure is a major problem in developed countries, leading to a high number of hospitalizations
and healthcare costs. The most common symptom of heart failure is congestion, which is also the primary reason
for hospitalization. Diuretics, particularly loop diuretics, are the cornerstone of the treatment of congestion.
Likewise, there are other types of diuretics with different pathways of action, bioavailability profiles, adverse reactions,
and effects on the cardiovascular and renal systems. Moreover, in recent years, new therapeutic alternatives
have been proposed for challenging cases of diuretic resistance, such as ultrafiltration through peripheral
access or peritoneal dialysis. The main objective of this article is to provide a step-guided approach to the management
of congestion in patients with heart failure in order to guide the medical practice. Despite the significant
amount of research published in recent years, there are no clear algorithms for managing acute heart failure.
Diuretics remain the primary treatment of acute heart failure, and nephron blockade is key, but new therapies
are emerging, and ongoing research is needed to develop better strategies for managing this condition.
Pathways to Green Nanomaterials: Plants as Raw Materials, Reducing Agents and Hosts
Authors: Fu Li
Published: July 2023

Pathways to Green Nanomaterials: Plants as Raw Materials, Reducing Agents and Hosts is a comprehensive guide that explores the fundamental aspects, synthesis methods, and various applications of nanomaterials derived from plants. This book is designed for postgraduate researchers, engineers, and scientists in the fields of materials science, biotechnology, and chemical engineering, as well as other disciplines involved in nanomaterial production and applications.

The book delves into different plant-mediated nanomaterials, analyzing their synthesis mechanisms and discussing the regulation and application prospects of plant synthesis. It covers topics such as nanocellulose, biochar materials, plant exosomes, polyphenol nanoparticles, and the phytotoxicity and uptake of nanomaterials by plants. Additionally, it explores the research progress and applications of plant virus nanoparticles in the medical field, including drug delivery, molecular imaging, and vaccine preparation. Readers will be familiarized with the synthetic methods, characterization, and applications of green nanomaterials, paving the way for future studies on plants and their phytochemical constituents.

With its comprehensive coverage of plant-derived nanomaterials and their diverse applications, Pathways to Green Nanomaterials: Plants as Raw Materials, Reducing Agents and Hosts serves as a valuable resource for researchers seeking to understand the potential of plants as sustainable sources for nanomaterial production.
Redox Signaling, Oxidative Stress in Cardiovascular Disease –basic Science and Clinical Aspects
Authors: Matata Bashir , Elahi Maqsood
Published: July 2023

The generation of certain species of biomolecules described as reactive oxidant species (ROS e.g., superoxide, O2 -; hydrogen peroxide, H2O2; hydroxyl radicals (OH.)) and reactive nitrogen species (RNS e.g., peroxynitrite, OONO-; nitric oxide, •NO) is a critical step in health and disease . These species play critical roles in cell defences in both animals, and plants. They also perform an important function in the regulation of key cellular signalling pathways such as cell differentiation, proliferation, migration, and apoptosis (commonly described as redox signalling pathways). The imbalance between the levels of ROS and RNS generated to that of antioxidant species may lead to oxidative stress and biomolecular damage, especially in situations where the latter are depleted. Redox biology and oxidative stress are particularly important in ischaemia-reperfusion associated diseases in particular the pathogenesis of cardiovascular disease (CVD). CVD is a major cause of mortality on a global scale, although the exact mechanisms underlying the pathological process are not fully understood. It is believed that ROS play a pivotal role in the progression of CVD. In particular, recent evidence suggests that the development of atherosclerosis is modulated by ROS and influenced by other factors such as inflammatory responses, disturbed blood flow, and arterial wall remodelling. This chapter provides an overview of the pathways of oxidative stress and redox-regulated signalling underlying the genesis and progression of cardiovascular disease.
Prevention of Reperfusion Injury in Acute Myocardial Infarction: A “flashback” Journey of Novel Strategies Based on the Potential Therapeutic Role of Antioxidants
Authors: Salazar-Cornejo Francisco , Gajardo Abraham , Kogan Marcelo J. , Rodrigo Ramón
Published: July 2023

It has been recognized that oxidative stress plays a key role in the
development of cardiac alterations derived from events of ischemia followed by
reperfusion, such as in the clinical setting of acute myocardial infarction of patients
subjected to coronary angioplasty. During ischemia, due to the occlusion of a coronary
branch, biochemical events responsible for anaerobic metabolism, ATP availability and
impairment of cell ionic homeostasis are the major deleterious effects. Following the
onset of reperfusión, a burst of reactive oxygen species occurs, thus accounting for
increased tissue damage due to the endovascular intervention. This iatrogenic damage
has not been adequately treated to date. Among the many pharmacological attempts,
cardioprotection with antioxidants should be mentioned; however, the experimental
studies have not been translated into successful clinical trials aimed to prevent this
enhancement of cardiac damage, despite some beneficial effects have been reported in
the clinical outcome of the patients. This chapter aimed to present the hypothesis that
the combination of antioxidant effects should improve the cardioprotection of the
patients subjected to coronary angioplasty following acute myocardial infarction.
Therefore, we present an update of previous attempts at cardioprotection with an
antioxidant alone and give the basis for the expected improved protection by using two
or more antioxidant compounds exerting different mechanisms that could enhance the
beneficial protective effect.