bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Nasal In-situ Gel Formulation of Fexofenadine HCl Using Gellan Gum (Gelerite®)
Authors: Amarsing Tadavi S , Pandit Pawar S
Published: April 2023

This study aimed to develop and assess an in-situ nasal gel containing fexofenadine hydrochloride for nasal administration by employing polymers with in-situ gelling characteristics. Formulations containing Gelerite, HPMC K4M and β-cyclodextrin were used to formulate in situ nasal gel. Formulations were liquid before administration and quickly converted to gel after nasal administration. The FTIR studies of drugs, polymers and physical mixtures of drug polymers were carried out. These research results indicated that, in comparison to pure drugs, there have been no considerable modifi cations in the drug bands. Hence, the FTIR study revealed that the formulation doesn’t have any drug-polymer interaction. In order to estimate rheological studies, a Fungilab Brookfi eld viscometer was used to test the formulation’s viscosity. The ranges of the rheological properties of the solution and gel were shown to be 91 ± 1.73 to 125 ± 0.77 and 2740 ± 1.55 to 4675 ± 1.43, respectively. The gel strength of formulations F1 to F9 was found to be in the range of 34 ± 1.00 to 51.23 ± 1.77 seconds. It was shown that the viscosity of the formulation decreased at increasing shear stress, exhibiting shear thinning behavior. A viscosity of formulation increase was noticed with an increase in polymer ratio. All formulations were subjected to an in-vitro diff usion analysis, which will demonstrate the impact of various factors on the formulation’s ability to release the drugs.
Formulation and Evaluation of Venlafaxine Hydrochloride Osmotic Tablets
Authors: Bansode Ashwini , Devhadrao Nitin , Sable Vijay , Tare Manoj , Baheti Dwarkadas , Dama Ganesh , Tare Harshal
Published: April 2023

Sustained-release tablets of venlafaxine HCl were designed using a controlled porosity osmotic formulation. This study aimed to develop and test an osmotic pump tablet with controlled porosity containing venlafaxine hydrochloride. Because of its excellent water solubility and near-to-one bioavailability, the antidepressant venlafaxine hydrochloride (VH) is placed in Biopharmaceutical Classifi cation System (BCS) class 1. Its short elimination half-life of 5 hours means that patients rarely take it as directed because they have to take two doses each day to make up for it. As a result, there is a high clinical and economic potential for a VH controlled administration dose form that can increase patient compliance. We looked on the dynamics between pharmacological excipients using FTIR. The core of the tablet was made using wet granulation, and the tablets were then covered. After 24 hours of in vitro testing, the drug’s release profi le was consistent with expectations. It was discovered that the rate of drug release increased with increasing pore former concentration, however, the percentage weight gain of the tablet coating inversely associated with the amount of pore former used. Drug release was investigated in relation to pore past weight development and weight percentage. SEM confi rmed optimised (F7) batch’s micro porous structure.
Synthesis, Characterization, and Photocatalytic Activity of Prepared MWCNT/ZnO Nanocomposite as a Model of Dyes and Pharmaceutical Compounds Removal
Authors: Aljeboree Aseel M , Obaies Diana M , Ali Zayneb M , Al-Abdeen Salah H Z , Alkaim Ayad F
Published: April 2023

The photocatalytic decomposition of brilliant green (BG) dye under several conditions was studied using MWCNT/ZnO nanocomposite. Nanocomposites were prepared via utilizing a hydrothermal process. The MWCNT/ZnO nanocomposite properties were studied using techniques (FESEM, and EDX). The most important factors aff ected the photocatalytic process were studied, like mass of MWCNT/ZnO nanocomposite, concentration of brilliant green (BG) dye, light intensity. The results showed that the photolysis process was low at fi rst and then increased with time. From the results, the photocatalytic decomposition effi ciency increased with the surface weight MWCNT/ZnO nanocomposite of (0.1–0.4) g. This also showed that with an increase BG dye concentration, the photolysis effi ciency decreased, and showed that the photolysis effi ciency was improved by increasing the light intensity.
Centrifugal Melt Spun Microfi brous Solid Dispersion of Diclofenac Sodium with Enhanced Solubility
Authors: Priya Rodge , Satish Shirolkar
Published: April 2023

A lower dissolution rate of poorly soluble drugs is the prime factor aff ecting their bioavailability. The centrifugal melt spinning method is a simple, aff ordable and scalable technique to prepare microfi bers with enhanced solubility and dissolution rate. This study aimed to enhance the solubility and dissolution rate of poorly soluble drug diclofenac sodium by centrifugal melt spinning technique. Microfi brous solid dispersion of diclofenac sodium 10% w/w with sucrose were prepared to utilize a cotton candy device. The dissolution studies revealed that the drug-loaded microfi bers released 98.10 ± 0.52% of drug within 5 minutes as compared with pure drug and physical mixture. The drug-loaded microfi bers were bead-free with uniform morphology and diameter of 13.25 ± 4.4 μm. The centrifugal melt-spinning process converted the drug and carrier to amorphous state, which was further confi rmed from the calorimetric and crystallographic study results. The results indicated that the centrifugal melt spinning process rapidly produced microfi bers with improved solubility and dissolution rate. The results of this study have shown that the centrifugal melt spinning technique may provide an easy, highly scalable, and adaptable fabrication technique to increase the solubility and rate of dissolution of poorly soluble drugs.
Antimicrobial Foot Deodorizing Spray
Authors: Prashant Patankar , Vitthal Chopade , Praveen Chaudhari
Published: April 2023

OBackground: Sanitizers are used to sanitize our hands to make them germ-free. However, it is found that people either forget or neglect to sanitize their feet. This act may lead to carrying germs to home or passing from one person to another, possibly spreading infection. Additionally, sweaty feet and foot odor have been found to be common nowdays. The presence of foot microfl ora like Staphylococcus epidermis, Bacillus subtilis and Propionibacterium Acnes can lead to the formation of isovaleric and propionic acids, which are responsible for the characteristic odor of feet. Objectives: This paper is aimed to develop a natural antimicrobial foot spray that exhibits a high evaporating rate, high antimicrobial activity, and an appropriate spray pattern. Methods: An antimicrobial formulation containing alcohol and natural active/s having antimicrobial activity is developed, which controls foot odor and infection or sanitizes feet. Results: The spray formulation of the present research contains lemon oil, neem oil and tulsi oil which have antimicrobial activity as well as being oil, they help in long-lasting skin moisturization. Regular use of foot spray deodorizes and prevents foot odor from, ensuring clean and healthy feet. The spray can be used anywhere with the ease of application which covers the feet area susceptible for odor generation and germ deposit. Conclusion: The spray exhibited the potential application as a rapidly dried antimicrobial spray for foot deodorant. It showed desired properties such as clarity, consistency, spreadability, quick absorption post-application, non-stickiness, non-dryness, and stability. The spray demonstrated antibacterial effi ciency against the bacteria responsible for producing a strong foot odor
Eff ect of Gymnema sylvestre in the Control of Diabetes: A Review
Authors: . Aditi , Sharma Luxita , More Priyanka , Ghangale Gauri , Tare Harshal
Published: April 2023

Gymnema sylvestre is a plant of the Asclepiadaceae family that grows worldwide. It is one of the most potent medicinal plants. G. sylvestre leaves are commonly utilised in the treatment of diabetes mellitus.In Indian herbal medicines, it is used as a diuretic drug. The most important active chemical ingredient taken out from the Gymnema plant are gymnemic acids which help prevent glucose absorption. This herb is famous for its antihelmentic, anti-infl ammatory, diuretic and stomach-friendly qualities. Leucoderma, constipation, hemorrhoids, jaundice, cardiopathy, asthma, bronchitis and dyspepsia are said to be treated with this plant. The Gymnema leaves are chewed to reduce the appetite for sweet and bitter items and applied on the aff ected body regions to heal a variety of illnesses. An examination of the literature found that the plant has anti-infl ammatory, anti-obesity, hypolipidaemic, antidiabetic, free radical scavenging and antibacterial properties. According to literature reviews, Gymnema is an extensively used plant for the cure and management of a lot of disorders and is a key constituent in numerous ayurvedic formulations. However, scientists have not made much eff ort to prove its effi cacy. The current review focuses on G. sylvestre’s folk and ayurvedic usage and pharmacognostic, pharmacological and phytochemical research. G. sylvestre may aid weight reduction by reducing sweet cravings and controlling blood sugar levels. This review highlights the plant description, literature and phytochemistry of G. sylvestre. It also talks briefl y about diabetes mellitus and how G. sylvestre can be useful in the treatment of it. We also discuss about the side eff ects and toxicity of it.
A Narrative Review on Drug Loaded Nanosponges as a Carrier for Drug Delivery
Authors: Salunkhe Anuradha , More Smita , Dhole Shashikant
Published: April 2023

Long-term attempts to create effi cient, targeted medication delivery systems have been delayed by the complexity of the chemical interactions required to build drug delivery systems. Colloidal nanosponges may be adapted to operate with hydrophilic or hydrophobic medicines. This implies that issues with medicine toxicity, reduced bioavailability, and widespread drug release might all be addressed. A nanosponge is a microscopic sponge that can navigate its way to the required location within a living organism. The drug is gently released as the patch clings to the skin of the affl icted region. The nanosponge’s porous construction allows it to trap drug molecules and release them gradually. Perhaps the most exciting development in the pharmaceutical industry is the nanosponge drug delivery device (NSDDS). This review aims to give readers an in-depth look at how nanosponges are made, evaluated, and put to use in the medical fi eld.
Surgical treatment of rhegmatogenous retinal detachment using air tamponade and C3F8 gas tamponade
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Shkvorchenko D.O. , Khrisanfova E.S. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Uzunyan D.G. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation
Published: April 2023

Relevance. Retinal detachment is a serious disease, that requires immediate surgical treatment. If there is no doubt about the need for urgent surgical treatment, then the question of choosing tamponing substance after retinal immobilization remains open. Often there are no clear criteria for choosing one or another tamponing substance and this issue is determined by the preference of the surgeon. Purpose. To evaluate effectiveness and compare result of surgical treatment of rhegmatogenous retinal detachment using air and C3F8 gas tamponade. Material and methods. Surgical treatment of 43 patients diagnosed with rhegmatogenous retinal detachment was performed and the results of treatment were evaluated. All patients were divided into 2 groups. The first group included 23 patients with the best corrected visual acuity 0.01– 0.9 (±0.06). Surgical treatment of patients from this group was completed with sterile air tamponade. The second group included 20 patients with the best corrected visual acuity of 0.01–0.8 (±0.08). Surgical treatment was completed with a 2.5% C3 F 8 gas tamponade. Results. By the third month of follow-up after surgical treatment B-scan data showed no pathology in all cases of both groups. Visual acuity in group 1 was 0.55-1.0 (±0.063), in group 2 was 0.45–1.0 (±0.061). Light sensitivity in group 1 was 24.5–30.1 (±0.34) dB, in group 2 was 23.1–27.7 (±0.41) dB. Conclusion. Given the comparable clinical results, air tamponade in surgery for rhegmatogenous retinal detachment is preferable than using 2.5% C 3 F 8 gas tamponade. Key words: rhegmatogenous retinal detachment, surgical treatment, air tamponade, C3F8 gas tamponade
Modern technologies of microbiological research in ophthalmology. part 1
Authors:   Eye Microsurgery Ekaterinburg Center, Ekaterinburg, Russian Federation, Shilovskikh O.V. , Ponomarev V.O. ,   Eye Microsurgery Ekaterinburg Center, Ekaterinburg, Russian Federation, Kazaikin V.N. ,   Eye Microsurgery Ekaterinburg Center, Ekaterinburg, Russian Federation, Kulikov A.N. ,   Military Medical Academy named after S.M. Kirov, St. Petersburg, Russian Federation, Demchenko N.S. ,   Eye Microsurgery Ekaterinburg Center, Ekaterinburg, Russian Federation, Tkachenko K.A. ,   Eye Microsurgery Ekaterinburg Center, Ekaterinburg, Russian Federation, Beikin Y.B. ,   Clinical and Diagnostic Center, Ekaterinburg, Russian Federation, Rozanova S.M. ,   Clinical and Diagnostic Center, Ekaterinburg, Russian Federation, Kyrf M.V. ,   Clinical and Diagnostic Center, Ekaterinburg, Russian Federation
Published: April 2023

Purpose. To highlight modern microbiological technologies for the identification of microorganisms as: mass spectrometry, polymerase chain reaction (PCR), sequencing, laser light scattering. Material and methods. To carry out the review, a search was carried out for scientific publications of domestic and foreign authors on the resources PubMed, Medline, eLIBRARY from 2008 to 2021, devoted to the currently existing methods of identifying microorganisms with an emphasis on ophthalmological microbiological diagnostics. Results. Modern microbiological technologies for the identification of microorganisms are able to assess not only the presence of the pathogen, but also to record its viability, the degree of virulence, currently implemented on the basis of modern technologies: mass spectrometry, polymerase chain reaction (PCR), sequencing and others. Conclusion. The microbiological technologies presented in the review make it possible to ensure high speed, productivity, sufficient sensitivity and economic availability of microbiological analysis, and are able to increase the probability of a positive outcome of the therapy. Key words: identification of microorganisms, polymerase chain reaction, sequencing, mass spectrometry
Erspectiva de género en el acceso a la carrera judicial
Authors: Campo Gonzalo Marta
Published: April 2023

A finales del siglo XX surgió el término “perspectiva de género”, que, en el ámbito judicial, supone el deber del juez de interpretar y aplicar las normas jurídicas de forma que se restablezca la igualdad entre el hombre y la mujer. Este artículo tiene por objeto explicar qué formación reciben en materia de perspectiva de género los opositores y, posteriormente, los jueces en prácticas antes de llegar a un juzgado. Para ello, lo primero que hay que indicar es que para ser juez en España hay que superar una fase teórica de oposición consistente en memorizar 328 temas. Y, posteriormente, una fase práctica que tiene una duración de dos años: el primero en la Escuela Judicial de Barcelona, y el segundo en un juzgado bajo la supervisión de un magistrado tutor. En cuanto a la fase de oposición, el programa de temas experimentó una importante modificación en 2019 a raíz de la reforma del art. 310 de la Ley Orgánica del Poder Judicial, que ordenaba incluir en las pruebas selectivas el estudio del principio de igualdad, medidas contra la violencia de género, y normativa europea e internacional en materia de igualdad. Por lo que se refiere a la Escuela Judicial, la formación incluye jornadas de perspectiva de género, principalmente civil y penal, pero también contencioso administrativo y laboral. Asimismo, se hacen simulaciones de juicios donde los jueces en prácticas deben dirigirse a la víctima aplicando los conocimientos adquiridos en materia de perspectiva de género. Por último, cabe destacar la realización obligatoria del curso HELP del Consejo de Europa sobre el Convenio de Estambul y la violencia de género. En definitiva, se trata de una formación integral y especializada, para que cuando los jueces lleguen a su primer juzgado sean capaces de plasmar la perspectiva de género en sus resoluciones judiciales.
PENDIDIKAN GRATIS DI ERA KAPITALIS DALAM USAHA PEMERATAAN HAK ATAS PENDIDIKAN
Authors: Permatasari Anggi Novella , Syafi’i Imam
Published: April 2023

Education is the right of everyone to get the opportunity to develop their potential through a process called learning which is said to be able to break the chain of poverty. However, has the implementation of this statement been running properly in Indonesia? That every citizen has the same rights in the form of the opportunity to attend school to university? Is “Education for All” just an empty program? The basic concept of equal opportunity to receive education which is focused on equality in education and equity in education seems to have not worked out ideally or even hindered each other. Discrimination of society on the basis of status and class to obtain privileges in obtaining educational opportunities is also still the biggest enemy for the basis of education for all. All kinds of arguments were expressed, ranging from government regulations that change frequently, low public awareness of the importance of education, the education ladder that feels the need to sacrifice a lot of money, and free education policies that sometimes do not match the reality and expectations of the community. By going through the library research method, this journal will more or less discuss how the principle of free education is often found contradicting the practice of educational capitalism which is so rampantly multiplying in the middle of the 4.0 era which actually requires the younger generation from the lower classes to the upper classes to continue to develop and continue to explore their potential through education.
SOCIAL CAPITAL IN THE DEVELOPMENT OF KEMBANG SIALANG JOINT BUSINESS GROUP PEKANBARU CITY
Authors: Ningtias H Septia Ayu , Susanti Rina
Published: April 2023

This article describes the potential of social capital in trust, networks, and norms for developing KUB Kembang Sialang business. Social capital is examined in the pattern of membership and group relationships with partners using a qualitative approach to collecting data through in-depth interviews and observations—five informants using the purposive sampling technique and one key informant from Sialang Munggu Village. The research results show potential for social capital (with elements of trust, networks, and norms) in membership and with partners. This element of social capital plays a role in the development of group businesses by increasing cooperation between group memberships and partners, including improving order services and marketing group products in the form of wallets, mukenah (prayer clothe), masks, pencil cases, bags, tanjak, etc.
VALUES OF CHARACTER EDUCATION IN THE WEDDING SAPRAHAN TRADITION IN THE VILLAGE OF LELA, TELUK KERAMAT DISTRICT, SAMBAS REGENCY
Authors: Yafi Reyhan Ainun , Kumalasari Dyah , Irawan Ria , Firmansyah Haris , Arifiyanti Fitria
Published: April 2023

This research examines the values of character education of the people of Lela Village in the tradition of marriage saprahan. The Malay community owns the saprahan tradition, which is still maintained. This study aims to analyze whether the saprahan tradition in Lela Village contains character education values and is a factor in preserving the tradition. The method used in this study is descriptive qualitative with an ethnographic approach. The sources used were interviews with community leaders, traditional leaders, and youth of Lela Village. The results showed that the implementation of the marriage saprahan tradition there are several values of character education in the marriage saprahan tradition, including religious values with the indication of the philosophy of the number of tools and people involved. Second, the creative value seen from the use of modern tools rather than traditional tools because they are already scarce. Third, democratic values demonstrated through the deliberations of local communities. Fourth, the communicative value that can be seen from the way the owner is happy to gather the community. Fifth, the value of social care can be seen from the involvement of youth and ethnicities other than Malays by attending invitations. And sixth, the value of responsibility is seen from the division of labor given to each implementing committee. However, the community needs to pay attention to regeneration to continue to be able to preserve the tradition of wedding ceremony in Lela Village, Teluk Keramat District, Sambas Regency.
IMPLEMENTATION OF LEARNING PROCESS IN THE FREEDOM CURRICULUM AT SENIOR HIGH SCHOOL (SMA) 3 SUNGAI KAKAP
Authors: Prancisca Stella , Nurani Lusia Marliana , Chappell Cary
Published: April 2023

This study aims to reveal the implementation of the Kurikulum Merdeka [Freedom Curriculum] at the State Senior High School [SMAN] 3 Sungai Kakap which is implemented without completely changing the components of the 2013 Curriculum. This research used the qualitative method with the type of case study on the 10th grade students. The data were collected in the following stages: pre-research, research and post-research. The results of the research show that SMAN 3 Sungai Kakap only implements the Freedom Curriculum in 10th grade; not in 11th grade and 12th grade. This is because it is still a try-out period. The implementation of the Freedom Curriculum is considered by the school to be simpler than the 2013 curriculum. The project-based P5 program at SMAN 3 Sungai Kakap is carried out by students on Fridays with exhibitions of practicum learning outcomes. Even though the Freedom Curriculum has just been implemented at SMAN 3 Sungai Kakap, teachers have received more and better information on student achievement. However, it always requires good experience and knowledge from teachers and educators at the school. The implementation of the Freedom Curriculum at SMAN 3 Sungai Kakap, in addition to the 2013 curriculum, is in the form of a practicum program and teachers’ collaboration with each other. In addition to the learning process, it still covers the components of the 2013 curriculum. In fact, the Freedom Curriculum complements the 2013 curriculum, such as building the character of local wisdom and values, and increasing students potential, interest, and talents that continue to be pursued in the Freedom Curriculum at SMAN 3 Sungai Kakap.
Marker-assisted selection and use of molecular markers in sunflower breeding for resistance to diseases and parasites
Authors: Kucherenko Ye. , Zviahintseva A. , Kobyzeva L. , Kolomatska V. , Makliak K. , Vasko N. , Zuieva K. , Lutsenko T.
Published: April 2023

Recently, the problem of phytosanitary condition of sunflower crops has been exacerbated, which is associated with violation of crop rotations and, as a consequence, spread of common diseases. Selection for resistance to biotic factors requires comprehensive research into the crop biology and pathogens. The use of starting material, which is resistant to major pathogens and environmental stressors, in selection is a prerequisite for the breeding of highly productive hybrids. Significant progress in the breeding of heterosis sunflower hybrids has been achieved primarily due to stable inbred lines. However, their creation is time-consuming, taking 8-12 years. Selection of desirable genotypes and initial forms for crossing is complicated by the fact that it is driven by a set of polygenic traits that are prone to significant modification variability. The use of molecular genetic markers is a way to accelerate breeding. Marker-assisted selection breeding (MAS) has been theoretically justified in numerous publications and implemented in most breeding institutions around the world. However, in domestic breeding programs, MAS has not become widespread compared to traditional methods. Nevertheless, this breeding trend opens new opportunities for studying genetic diversity and determining kinship at the intraspecies and genus levels. The review provides information on the status and prospects of implementation of MAS in traditional plant breeding and highlights the achievements of modern biotechnology in sunflower breeding for resistance to biotic factors owing to molecular genetic markers. The MAS principles are outlined and the advantages of this method are described. Specific examples of application of the molecular approach during the development of starting material of sunflower for breeding for resistance to common diseases and parasites are given. The main stages and components of PCR analysis are also described. Inbred sunflower lines – carriers of the gene for resistance to the downy mildew pathogen are characterized and genetic passports using STS markers to the Pl6 locus have been formalized for 13 sunflower lines.
Ecological and faunistic analyses of the trematodes of the Little Grebe (Tachybaptus ruficollis (Pallas, 1764)) in Azerbaijan
Authors: Mahmudova Y.
Published: April 2023

The research was conducted from 1998 to 2019 at the nine water bodies of Azerbaijan. During the study, 94 individuals of the Little Grebes (Tachybaptus ruficollis (Pallas, 1764)) were examined by the method of complete helminthological dissection. As a result, 12 trematode species belonging to one order, seven families, and eight genera were found: Patagifer bilobus, Petasiger megacantha, P. skrjabini, Echinochasmus coaxatus, E. dietzevi, E. mordax, Mesorchis pseudoechinatus, Cryptocotyle concavum, Metorchis intermedius, Eucotyle cohni, Strigea falconis, Hysteromorpha triloba. Of these, three species (Petasiger megacantha, Echinochasmus coaxatus and E. dietzevi) are specific grebe parasites, while the others infect various waterfowl. Except for Strigea falconis, whose cercariae penetrate actively into the bird’s body and transform into metacercarie, all the trematode found are ingested by the birds and mature in their intestine. The grebe, as a fish-eating bird, is infected with six trematode species (Patagifer bilobus, Petasiger megacantha, Mesorchis pseudoechinatus, Cryptocotyle concavum, Metorchis intermedius, Hysteromorpha triloba) that parasite in fish at the stage of metacercaria. Other species use aquatic invertebrates as second intermediate hosts. We established that species diversity of the grebe trematodes depended on the reservoir size and the richness of its hydrofauna, increasing with the increase of both factors. The differences between the faunas of grebe trematodes in various water bodies depended on the distance between them and the similarity of their living conditions. Seven grebe trematode species (Petasiger megacantha, P. skrjabini, Echinochasmus coaxatus, E. dietzevi, Cryptocotyle concavum, Metorchis intermedius, Eucotyle cohni) belong to the northern group of helminthes, while the five species (Patagifer bilobus, Echinochasmus mordax, Mesorchis pseudoechinatus, Strigea falconis, Hysteromorpha triloba) are ubiquitous. Southern trematode species were absent from the examined birds. Presumably, this can be explained by the dominance of grebes from northern populations wintering on the water bodies of Azerbaijan.
The red blood cells cytometric characteristics of young fresh-water fish of various families
Authors: Sharamok T. , Yesipova N. , Kurchenko V.
Published: April 2023

The morphometric indices of red blood cells of young fish of various species inhabiting coastal zones of the water bodies were studied. The subjects of the research were the fish of four families: Carp (Alburnus alburnus, Carassius gibelio, Rhodeus amarus, Abramis brama, Rutilus rutilus), Needles (Syngnathus abaster nigro lineatus), Centrarchidae (Lepomis gibbosus), Loaches (Cobitis taenia taenia), Gobies (Neogobius fluviatilis). The hydroecological conditions were characterized by an intense oxygen regime, high content of phosphates, and heavy metals (zinc). The fish peripheral blood was taken from the tail vein; smears were made according to the classical Romanowsky-Giemsa method. Our research showed that the red blood cells of young fish belonging to the ecological group of inactive and unpretentious species (Neogobius fluviatilis, Carassius gibelio) had the largest cross-sectional area and a high index of nuclear-cytoplasmic ratio. The indicators of erythrocyte eccentricity were the highest in the active fish with high energy costs (Alburnus alburnus, Lepomis gibbosus). The largest number of erythrocytes with pathological events (cytolysis, karyolysis, pyknosis, poikilocytosis) was observed in the young Alburnus alburnus (14%), and the smallest one in Rhodeus amarus and Lepomis gibbosus (2–4%). In the individuals of Syngnathus abaster nigro lineatus affected by parasitic nematodes of the genus Ascaris, the number of erythrocytes with pathologies increased to 81%. Under the toxic load, destabilization of the fish circulatory system begins with the appearance of the young forms of erythrocytes as compensation for depleted mature erythrocytes and ends with the mass destruction of mature erythrocytes. Given these patterns, as well as the relatively low number of young ballast forms of erythrocytes and mature erythrocytes with pathological features, we can assume that the state of the red blood cells in the studied young fishes meets the conditional norm, with the exception of the blood of Syngnathus abaster nigro lineatus infected with parasites. In our opinion, the main characteristics of the fish red blood that reflect the fishes’ adaptive capacities are as follows: eccentricity ratio of erythrocytes, the nuclear-cytoplasmic ratio, ratio of the young ballast forms of erythrocytes, and the relative number of erythrocytes with pathology.
Las tecnologías de la información y la comunicación en el contexto educativo: Pedagogía, prácticas y experiencias
Authors: Gutiérrez Rodríguez Álvaro , Saza Garzón Ilber Darío , López García José David , Caraballo Cadena Hugo Eduardo , Gómez Jiménez Carlos Felipe
Published: April 2023

En este libro se presentan experiencias de aula que facilitan los procesos académicos a través del uso de las tecnologías de la información y la comunicación (TIC), con el propósito de contribuir al desarrollo profesional docente. En él se brinda apoyo didáctico, a través de elementos teóricos y prácticos que orientarán al docente en el ejercicio de la planeación, el diseño, creación y la implementación de ambientes de aprendizaje apoyados por diversas tecnologías. This book presents classroom experiences that facilitate academic processes by using information and communication technologies (ICT), encouraging teachers' professional development. All these experiences provide didactic support, through theoretical and practical elements that will guide the teacher in the planning, design, creation, and implementation of learning environments supported by different technologies.
Etnoecología con énfasis territorial, una propuesta para el fortalecimiento de las comunidades indígenas mhuysqa de Cota, Chía y Sesquilé, Cundinamarca – Colombia
Authors: Sepúlveda Varón Álvaro R. , Escobar Berón Germán , Naranjo Arcila Alejandra , Peñuela Uricoechea Magdalena
Published: April 2023

Previo a la invasión europea al “Nuevo Mundo” existían pueblos, naciones y estados en proceso de consolidación. En el territorio de la meseta cundiboyacense (actuales departamentos de Cundinamarca, Boyacá y parte de Santander) se extendía la Confederación mhuysqa, organización político-administrativa que agrupaba cuatro cacicazgos como unidades político-territoriales: el zipazgo de Bacatá, el zacazgo de Hunza, el territorio sagrado de Iraca y el territorio sagrado de Tundama, además de otros territorios autónomos (Herrera, 1993; Pérez, 2017).
Las plantas medicinales a través de la memoria histórica de nuestros abuelos
Authors: Rosero-Toro Jeison Herley , Gómez Fierro Wilmer Alberto , Brand Karen Viviana , Ceballos Arlen Camilo , Cerón Castaño Dayana Liceth , Cárdenas Castaño Juliana
Published: April 2023

La etnobotánica como disciplina que estudia las relaciones inminentes entre el ser humano con su entorno en los diferentes escenarios ecológicos y culturales constituye una herramienta ineludible e indispensable para el conocimiento tradicional milenario (Gil y Carmona, 2001). De esta manera, se han empleado y se han reconocido las formas de empleo de distintas plantas para aliviar diferentes dolencias, y se establecen técnicas o saberes mucho más ortodoxos y rudimentarios (Bermúdez et al., 2005).
Usos, manejo y comercialización del agraz (Vitis tiliifolia Schult.) en zona de reserva del río Las Ceibas (Neiva, Huila, Colombia)
Authors: Dueñas Gómez Hilda del Carmen , Cerquera Cerquera Rubén Darío
Published: April 2023

El presente documento está orientado a presentar los resultados del proyecto código 2594, financiado por la Vicerrectoría de Investigación y Proyección Social de la Universidad Surcolombiana, trabajo realizado por integrantes del Grupo de Investigación y Pedagogía en Biodiversidad, GIPB, de la Licenciatura en Ciencias Naturales y Educación Ambiental de la Universidad Surcolombiana, con el apoyo del profesor Alfonso Morelo de la Ossa, Grupo de Investigación Salud y Derechos Humanos, de la Universidad Surcolombiana, de personal de la CAM, la comunidad de la cuenca media del río Las Ceibas y vendedores de agraz del mercado campesino Coorpromercalixto, cuyo objetivo general fue definir los usos, formas de manejo y hábitos de comercialización del agraz (Vitis tiliifolia) en la comunidad de la cuenca media del río Las Ceibas (Neiva, Huila, Colombia), como parte del programa de aprovechamiento de recursos no maderables del bosque, liderado por la CAM.
Targeted Synthesis of Novel Bile Acids
Authors:   , Ure Elizabeth
Published: April 2023

Bile acids are amphiphilic steroids which serve to emulsify lipophilic nutrients and assist with the elimination of harmful substances from the body. Since the turn of the century, it has become apparent that bile acids have a secondary function as endocrine and paracrine signalling molecules, allowing them to mediate cholesterol, lipid and glucose homeostasis. This is achieved through interactions with nuclear and membrane-bound receptors such as the Farensoid X receptor (FXRα) and the G protein-coupled bile acid receptor (TGR5). These receptors are involved in the pathogenesis of metabolic and inflammatory liver disorders including: diabetes, obesity, non-alcoholic steatohepatitis and primary biliary cholangitis. Therefore, the bile acid-activated receptors have become attractive therapeutic targets.

The research herein describes the synthesis of bile acid scafolds in the search for candidates with high pharmacological activity at TGR5 and FXRα. The synthetic strategy began with a scalable Wanger-Meerwein type rearrangement of cholic acid, resulting in the preparation of novel chenodeoxycholic isomers. Further chemical manipulation of these chenodeoxycholic acid derivatives, with a focus on oxidation and alkylation chemistry, facilitated the development of a range of natural product analogues. Such compounds were included in a biological screen against TGR5 and FXRα, allowing an investigation into the structural elements required to affect the bile acid-activated receptors. This led to the identification of new agonists for TGR5; compounds with a pharmacodynamic response that rivals the leading TGR5 drug candidates currently in pre-clinical-development.
Collaborations of research and outreach projects in promoting the health of workers and students
Authors: Alves Luciana Valadão Vasconcelos , Seabra Anna Beatriz Pegas de Oliveira , Faria Magda Guimarães de Araujo , Ferreira Rejane Eleuterio
Published: April 2023

Objetivo: Mapear projetos de pesquisa e extensão de um instituto federal voltados para a promoção da saúde com base no referencial teórico das Universidades Promotoras da Saúde. Métodos: Trata-se de uma pesquisa documental, na qual mapeou-se, por meio de consulta pública a editais de seleção, projetos de pesquisa e extensão de um instituto federal, com vigência no período de 2016 a 2020. Realizou-se análise descritiva e interpretativa de títulos e resumos, identificando os projetos voltados para promoção da saúde em ambiente institucional. Resultados: Selecionou-se 18 projetos, sendo o ano com maior prevalência 2020 e o público-alvo predominante estudantes e trabalhadores. Os principais aspectos de promoção da saúde abordados foram: Bem-estar escolar; Hábitos saudáveis; Protagonismo em saúde; e Ambientes saudáveis. Conclusão: O instituto analisado possui projetos que o aproxima do movimento das Universidades Promotoras da Saúde, porém é importante incentivar abordagens de trabalho intersetoriais e multidisciplinares e ampliar a capacitação e a formação acadêmica em Promoção da Saúde.
PEMAHAMAN PELESTARIAN ALAM WARGA PINTUBESI DI KAB DELISERDANG
Authors: Aziz Lukgimin , Siregar Nurliani , Gea Elirani , Hutahaean Hasahatan
Published: April 2023

Conservation of nature, maintaining the balance of the ecosystem is an inseparable part of the divine mandate of God. Preserving nature and the balance of ecosystems means that we have done part of the faith. Community service by providing education on nature conservation is carried out to give residents a better understanding. The activity was carried out by selecting a group of residents in Pintubesi, especially Hindus. This implementation is based on the location of Pintubesi hamlet, Laurakit village in Deliserdang district, around (surrounded) nature with green forests. The life of the majority of residents is not farming, and a small number of broiler breeders. Therefore, to support nature conservation and maintain ecosystems, it is necessary to provide understanding to the residents there. The implementation of the activity uses the extension method by preparing materials and some practical materials during the extension. Meanwhile, residents were selected from a Hindu community to provide concentration and focus on counseling and monitoring after the counseling. From several counseling sessions, pleasant results were obtained regarding the understanding and awareness of participants in preserving nature and the role of humans in maintaining the balance of the ecosystem. Participants enthusiastically participated in each counseling session and arrived on time. Awareness and responsibility for conserving the surrounding nature are united by maintaining one's own farmland. Preserving and maintaining nature has been asked to become a lifestyle.
Penerapan Teknologi Tepat Guna Kompor Roket Biomassa Sebagai Solusi untuk Penghematan Penggunaan Kayu Bakar
Authors: Setiawan Adi , Nayan Ahmad , Farhan Mulkia Farhan , Arieandi Yogi Arieandi
Published: April 2023

Kompor merupakan salah satu peralatan yang menghasilkan panas yang tinggi yang dihasilkan dari proses pembakaran untuk kebutuhan rumah tangga seperti memasak dan memanaskan bahan makanan. Di daerah terpencil dan sering mengalami kelangkaan bahan bakar gas, diperlukan suatu teknologi tepat guna kompor roket biomassa sebagai alternatif alat memasak yang murah dan aman dalam pengoperasian. Desa Pantan Sinaku, Kabupaten Bener Meriah, Aceh merupakan salah satu daerah terpencil yang membutuhkan teknologi ini. Melalui kegiatan pengabdian kepada masyarakat, persoalan ini coba diatasi melalui beberapa tahapan kegiatan mulai dari (i) menyusun desain dan kebutuhan material untuk kompor roket, (ii) menguji-coba kompor dengan metode water boiling test (WBT) dan (iii) memperkenalkan teknologi kompor roket ke masyarakat. Pada pengujian awal kompor roket biomassa, diambil nilai hasil uji pembakaran tempurung kelapa dengan metode hot start, cold start dan simmer. Selanjutnya saat di lokasi, diuji penggunaan bahan bakar berupa kayu mangga dan kayu ranting kering. Dari hasil uji kompor roket diperoleh bahan bakar kayu mangga memiliki nilai efisiensi thermal paling tinggi yaitu 36% saat cold start, 42% hot start dan 41% simmer. Sedangkan nilai efisiensi termal terendah didapat saat memasak air menggunakan bahan bakar tempurung kelapa dengan nilai efisiensi 22% cold start, 18% hot start dan 25% simmer. Memasak dengan kayu ranting memiliki nilai efisiensi termal mencapai 31% cold start, 25% hot start dan 50% simmer. Teknologi yang diperkenalkan ini mendapat minat dan respon yang positif dari warga Desa Pantan Sinaku.
PELATIHAN MENGENAL FUROSHIKI KAIN PEMBUNGKUS TRADISIONAL DARI JEPANG YANG RAMAH LINGKUNGAN BAGI SISWA DI SMK KESEHATAN DAN PARIWISATA BANGKINANG
Authors: Basri Merri Silvia Basri , Rahayuningtyas Putri Rahayuningtyas , Sur Intan Sur
Published: April 2023

Abstrak

 

Furoshiki merupakan salah satu budaya tradisional Jepang yang berarti penggunaan kain tradisional yang ramah lingkungan sebagai pembungkus. Pada kehidupan sehari-hari furoshiki digunakan untuk membungkus barang-barang. Di era globalisasi furoshiki bermanfaat untuk mengurangi penggunaan plastik. Oleh karena itu perlu diadakannya workshop dan pembimbingan dalam penggunaan furoshiki di kalangan kaum muda khususnya siswa SMA dan SMK. Materi workshop meliputi, 1) Definisi furoshiki, 2) sejarah dan perkembangan furoshiki, 3) Jenis kain, ukuran dan motif furoshiki, 4) Harga furoshiki, 5)  Manfaat dan teknik membuat furoshiki. Metode yang digunakan dalam workshop ini adalah dari metode pendidikan masyarakat dan pelatihan dengan cara ceramah, diskusi dan pembimbingan. Peserta diperkenalkan dan diajarkan cara membuat furoshiki agar dapat berguna dalam kehidupan sehari-hari.  Kegiatan ini cukup berhasil jika dilihat dari antusiasnya para peserta dalam mengikuti workshop dan ditunjukkan oleh angket kepuasan peserta yang menyentuh angka 70%. Dengan adanya kegiatan workshop ini diharapkan generasi muda dapat lebih peduli terhadap lingkungan dan menambah wawasan peserta. Keberhasilan kegiatan ini berkat kerja sama yang baik dari anggota tim pengabdian masyarakat dengan Kepala Sekolah, Guru bahasa Jepang dan siswa SMK Kesehatan dan Pariwisata, Kota Bangkinang, Riau.

Kata kunci: Furoshiki,  kain pembungkus ramah lingkungan
EDUKASI PEMANFAATAN BAHAN ALAM SEBAGAI OBAT TRADISIONAL UNTUK PENCEGAHAN PENYAKIT DAN PERAWATAN KESEHATAN
Authors: Khairunnisa Fatiha , A’yuni Qurrota , Ul Haq Kautsar , Setyawati Harsasi Setyawati , Permana Ahmadi Jaya Permana , Ramadhan Rico Ramadhan , Raharjo Yanuardi Raharjo , Tanjung Mulyadi Tanjung , Sumarsih Sri Sumarsih , Hartati Hartati , Darmokoesoemo Handoko Darmokoesoemo
Published: April 2023

Salah satu upaya pemeliharaan kesehatan pada masa darurat seperti pandemi Coronavirus Disease 2019 (COVID-19) seperti saat ini dapat dilakukan dengan memanfaatkan bahan-bahan alam untuk diolah menjadi obat tradisional. Jamu sebagai salah satu jenis obat tradisional sekaligus warisan alam telah dimanfaatkan secara luas oleh masyarakat Indonesia untuk mencegah penyakit dan merawat kesehatan. Kegiatan Pengabdian Kepada Masyaraka (PKM) ini bertujuan memberikan edukasi kepada masyarakat terkait dengan kandungan kimia dan khasiat bahan-bahan alam seperti empon-empon serta pengolahan dan pemanfaatannya sebagai obat tradisional untuk merawat kesehatan. Kegiatan dilaksanakan melalui tatap muka secara langsung dengan tetap menerapkan protokol kesehatan yang berlaku. Tingkat keberhasilan dan kebermanfaatan kegiatan PKM diketahui dari respon masyarakat yang ikut serta. Secara umum, kegiatan PKM yang berupa pemaparan materi maupun praktik dapat terlaksana dengan baik. Materi yang disampaikan oleh narasumber dapat dipahami dan mudah untuk dipraktikkan. Kegiatan inii diharapkan turut berperan dalam meningkatkan pengetahuan dan keterampilan masyarakat mengenai bahan-bahan di alam yang memiliki kandungan kimia bermanfaat serta mengolahnya menjadi minuman berkhasiat untuk keluarga.
Revitalisasi “Image” Masyarakat Terhadap Jamu Sebagai Kearifan Lokal Menuju Level Internasional
Authors: Isnaeni Isnaeni , Puspitasari Ariel Dwi , Purnomo Minarni , Budiastuti Budiastuti , Suroso Adi , Trisnowati Ita
Published: April 2023

One of the ancestral heritage that has been used since 1135 M is jamu. People know jamu by several terms, including colonial jamu, by which “jamu gendong”, Nusantara jamu, and  millennial jamu are developed. The use of jamu was originally intended to maintain health, both to reduce or eliminate symptoms of illness. The use of jamu, which was initially empirically based, developed into a professionally formulated dosage form after laboratorial and clinical evaluating various active compounds. The problem that develops in the community is the reluctance of the millennial generation to consume jamu, due to its bitter taste and unattractive performance. To revitalize the public image of jamu, various efforts have been made, including socialization, modifying the appearance and taste of jamu so that it is suitable for public interest to the international level. This report provides an overview of training activities for making jamu using simple technology, but which can produce healthy, attractive dishes with distinctive flavors and aromas. The activity is carried out in synergy involving academics, practitioners who are members of the East Java Herbal Medicine Association (GP JAMU JATIM) which was initiated by the East Java Industrial Pharmacy Seminat Association (HISFARIN JATIM). The participants of the activity included the UMKM community, pharmacists, practitioners with the main target being residents of the Technical Implementation Unit for Bina Daksa Social Rehabilitation (UPT RSBD) of the Social Service of Bangil District, Pasuruan Regency.
Pendampingan Pemanfaatan Sumber Daya Lokal Untuk Meningkatkan Ekonomi Lokal
Authors: Rismayani Rismayani , Widayanti Baiq Harly , Fitra Furqonnur , Ovanda Langgamada Tri , Firdaus M. , Wahyuningsih Sri
Published: April 2023

Desa pengenjek memiliki potensi sumber daya lokal berupa ijuk dari pohon enau. Saat ini ijuk yang dihasilkan dari pohon enau ini setelah dikeringkan langsung dijual tanpa pengolahan lebih lanjut. Pembuatan ijuk dijadikan sebagai sumber mata pencaharian masyarakat di Desa Pengenjek. Besarnya potensi ijuk ini dapat dikembangkan menjadi berbagai produk yang memiliki nilai jual lebih tinggi. Sehingga dengan melihat potensi tersebut maka tujuan pengabdian ini adalah memanfaatkan potensi sumber daya lokal ijuk menjadi pot tanaman sehingga memiliki nilai jual yang lebih tinggi. Metode yang digunakan yaitu dengan memberikan pendampingan praktik di dalam pembuatan produk berbahan ijuk. Kegiatan pendampingan pemanfaatan ijuk ini dilakukan selama 1 pekan mulai dari persiapan bahan sampai pada praktik pembuatannya. Sasaran kegiatan merupakan kelompok perempuan di Desa Pengenjek baik usia remaja maupun dewasa. Hasil dari kegiatan ini meningkatnya keterampilan masyarakat dalam mengolah ijuk menjadi barang yang lebih berguna dan bernilai lebih tinggi. Harapannya dengan produk yang dihasilkan memiliki nilai jual yang tinggi maka pendapatan masyarakat Desa Pengenjek semakin meningkat sehingga tingkat kesejahteraan masayrakatpun dapat meningkat.