bluuebunny/crossref_metadata_2025 huggingface dataset:
Mesenchymal stem cell transplantation can restore lupus disease-associated miRNA expression and Th1/Th2 ratios in a murine model of SLE
Authors: Choi Eun Wha , Lee MinJae , Song Ji Woo , Shin Il Seob , Kim Sung Joo
Published: December 2016

C3.MRL-Faslpr/J mice spontaneously develop high titers of anti-dsDNA, mild glomerular nephritis, and severe lymphoproliferation symptoms. This study aimed to compare the effects of long-term serial administration of human adipose tissue-derived mesenchymal stem cells (ASCs), and cyclophosphamide treatment in C3.MRL-Faslpr/J mice using a murine SLE model. C3.MRL-Faslpr/J mice were divided into saline (C), cyclophosphamide (Y), and ASC (H) treatment groups. Background-matched control C3H mice treated with saline (N) were also compared. The Y group showed the greatest improvement in disease parameters, but with damaged trabecular integrity. ASC transplantation reduced anti-dsDNA levels, glomerular C3 deposition and CD138 proportion significantly, without trabecular damage. Furthermore, both cyclophosphamide and ASC treatment significantly decreased the ratio of Th1/Th2 compared with the saline-treatment. The expression levels of miR-31-5p, miR-96-5p, miR-182-5p, miR-183-5p, and miR-379-5p were significantly higher, while those of miR150-5p were significantly lower in the C group than in the N group. The expression levels of miR-96-5p, miR-182-5p in the Y and H groups were significantly lower than in the C group. Thus, treatment with cyclophosphamide or ASC can change miRNAs and decrease miR-96-5p and miR-182-5p expression, as well as decreasing the CD138 proportion and the Th1/Th2 ratio, which might be involved in the therapeutic mechanism.
Diverse specificity of cellulosome attachment to the bacterial cell surface
Authors: Brás Joana L. A. , Pinheiro Benedita A. , Cameron Kate , Cuskin Fiona , Viegas Aldino , Najmudin Shabir , Bule Pedro , Pires Virginia M. R. , Romão Maria João , Bayer Edward A. , Spencer Holly L. , Smith Steven , Gilbert Harry J. , Alves Victor D. , Carvalho Ana Luísa , Fontes Carlos M. G. A.
Published: December 2016

During the course of evolution, the cellulosome, one of Nature’s most intricate multi-enzyme complexes, has been continuously fine-tuned to efficiently deconstruct recalcitrant carbohydrates. To facilitate the uptake of released sugars, anaerobic bacteria use highly ordered protein-protein interactions to recruit these nanomachines to the cell surface. Dockerin modules located within a non-catalytic macromolecular scaffold, whose primary role is to assemble cellulosomal enzymatic subunits, bind cohesin modules of cell envelope proteins, thereby anchoring the cellulosome onto the bacterial cell. Here we have elucidated the unique molecular mechanisms used by anaerobic bacteria for cellulosome cellular attachment. The structure and biochemical analysis of five cohesin-dockerin complexes revealed that cell surface dockerins contain two cohesin-binding interfaces, which can present different or identical specificities. In contrast to the current static model, we propose that dockerins utilize multivalent modes of cohesin recognition to recruit cellulosomes to the cell surface, a mechanism that maximises substrate access while facilitating complex assembly.
Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction
Authors: Richard Sébastien , Lapierre Vanessa , Girerd Nicolas , Bonnerot Mathieu , Burkhard Pierre R. , Lagerstedt Linnéa , Bracard Serge , Debouverie Marc , Turck Natacha , Sanchez Jean-Charles
Published: December 2016

Accurately determining time-of-onset of cerebral infarction is important to clearly identify patients who could benefit from reperfusion therapies. We assessed the kinetics of peroxiredoxin 1 (PRDX1), a protein involved in oxidative stress during the acute phase of ischemia, and its ability to determine stroke onset in a population of patients with known onset of less than 24 hours and in a control group. Median PRDX1 levels were significantly higher in stroke patients compared to controls. PRDX1 levels were also higher from blood samples withdrawn beforevs.after 3 hours following stroke onset, and beforevs. after 6 hours. ROC analysis with area under the curve (AUC), sensitivity (Se) and specificity (Sp) determined from the Youden index was performed to assess the ability of PRDX1 levels to determine onset. Diagnostic performances of PRDX1 levels were defined by an AUC of 69%, Se of 53% and Sp of 86% for identifying cerebral infarction occurring <3 hours, and an AUC of 68%, Se of 49% and Sp of 88% for cerebral infarction occurring <6 hours. These first results suggest that PRDX1 levels could be the basis of a new method using biomarkers for determining cerebral infarction onset.
An Integrated Strategy for Global Qualitative and Quantitative Profiling of Traditional Chinese Medicine Formulas: Baoyuan Decoction as a Case
Authors: Ma Xiaoli , Guo Xiaoyu , Song Yuelin , Qiao Lirui , Wang Wenguang , Zhao Mingbo , Tu Pengfei , Jiang Yong
Published: December 2016

Clarification of the chemical composition of traditional Chinese medicine formulas (TCMFs) is a challenge due to the variety of structures and the complexity of plant matrices. Herein, an integrated strategy was developed by hyphenating ultra-performance liquid chromatography (UPLC), quadrupole time-of-flight (Q-TOF), hybrid triple quadrupole-linear ion trap mass spectrometry (Qtrap-MS), and the novel post-acquisition data processing software UNIFI to achieve automatic, rapid, accurate, and comprehensive qualitative and quantitative analysis of the chemical components in TCMFs. As a proof-of-concept, the chemical profiling of Baoyuan decoction (BYD), which is an ancient TCMF that is clinically used for the treatment of coronary heart disease that consists of Ginseng Radix et Rhizoma, Astragali Radix, Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle, and Cinnamomi Cortex, was performed. As many as 236 compounds were plausibly or unambiguously identified, and 175 compounds were quantified or relatively quantified by the scheduled multiple reaction monitoring (sMRM) method. The findings demonstrate that the strategy integrating the rapidity of UNIFI software, the efficiency of UPLC, the accuracy of Q-TOF-MS, and the sensitivity and quantitation ability of Qtrap-MS provides a method for the efficient and comprehensive chemome characterization and quality control of complex TCMFs.
Next-generation systematics: An innovative approach to resolve the structure of complex prokaryotic taxa
Authors: Sangal Vartul , Goodfellow Michael , Jones Amanda L. , Schwalbe Edward C. , Blom Jochen , Hoskisson Paul A. , Sutcliffe Iain C.
Published: December 2016

Prokaryotic systematics provides the fundamental framework for microbiological research but remains a discipline that relies on a labour- and time-intensive polyphasic taxonomic approach, including DNA-DNA hybridization, variation in 16S rRNA gene sequence and phenotypic characteristics. These techniques suffer from poor resolution in distinguishing between closely related species and often result in misclassification and misidentification of strains. Moreover, guidelines are unclear for the delineation of bacterial genera. Here, we have applied an innovative phylogenetic and taxogenomic approach to a heterogeneous actinobacterial taxon, Rhodococcus, to identify boundaries for intrageneric and supraspecific classification. Seven species-groups were identified within the genus Rhodococcus that are as distantly related to one another as they are to representatives of other mycolic acid containing actinobacteria and can thus be equated with the rank of genus. It was also evident that strains assigned to rhodococcal species-groups are underspeciated with many misclassified using conventional taxonomic criteria. The phylogenetic and taxogenomic methods used in this study provide data of theoretical value for the circumscription of generic and species boundaries and are also of practical significance as they provide a robust basis for the classification and identification of rhodococci of agricultural, industrial and medical/veterinary significance.
Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer
Authors: Miyo Masaaki , Konno Masamitsu , Nishida Naohiro , Sueda Toshinori , Noguchi Kozo , Matsui Hidetoshi , Colvin Hugh , Kawamoto Koichi , Koseki Jun , Haraguchi Naotsugu , Nishimura Junichi , Hata Taishi , Gotoh Noriko , Matsuda Fumio , Satoh Taroh , Mizushima Tsunekazu , Shimizu Hiroshi , Doki Yuichiro , Mori Masaki , Ishii Hideshi
Published: December 2016

Tumor cells respond to their microenvironment, which can include hypoxia and malnutrition, and adapt their metabolism to survive and grow. Some oncogenes are associated with cancer metabolism via regulation of the related enzymes or transporters. However, the importance of metabolism and precise metabolic effects of oncogenes in colorectal cancer remain unclear. We found that colorectal cancer cells survived under the condition of glucose depletion, and their resistance to such conditions depended on genomic alterations rather than on KRAS mutation alone. Metabolomic analysis demonstrated that those cells maintained tricarboxylic acid cycle activity and ATP production under such conditions. Furthermore, we identified pivotal roles of GLUD1 and SLC25A13 in nutritional stress. GLUD1 and SLC25A13 were associated with tumor aggressiveness and poorer prognosis of colorectal cancer. In conclusion, GLUD1 and SLC25A13 may serve as new targets in treating refractory colorectal cancer which survive in malnutritional microenvironments.
Online flow cytometry reveals microbial dynamics influenced by concurrent natural and operational events in groundwater used for drinking water treatment
Authors: Besmer Michael D. , Epting Jannis , Page Rebecca M. , Sigrist Jürg A. , Huggenberger Peter , Hammes Frederik
Published: December 2016

Detailed measurements of physical, chemical and biological dynamics in groundwater are key to understanding the important processes in place and their influence on water quality – particularly when used for drinking water. Measuring temporal bacterial dynamics at high frequency is challenging due to the limitations in automation of sampling and detection of the conventional, cultivation-based microbial methods. In this study, fully automated online flow cytometry was applied in a groundwater system for the first time in order to monitor microbial dynamics in a groundwater extraction well. Measurements of bacterial concentrations every 15 minutes during 14 days revealed both aperiodic and periodic dynamics that could not be detected previously, resulting in total cell concentration (TCC) fluctuations between 120 and 280 cells μL−1. The aperiodic dynamic was linked to river water contamination following precipitation events, while the (diurnal) periodic dynamic was attributed to changes in hydrological conditions as a consequence of intermittent groundwater extraction. Based on the high number of measurements, the two patterns could be disentangled and quantified separately. This study i) increases the understanding of system performance, ii) helps to optimize monitoring strategies, and iii) opens the possibility for more sophisticated (quantitative) microbial risk assessment of drinking water treatment systems.
Two genomic regions associated with fiber quality traits in Chinese upland cotton under apparent breeding selection
Authors: Su Junji , Li Libei , Pang Chaoyou , Wei Hengling , Wang Caixiang , Song Meizhen , Wang Hantao , Zhao Shuqi , Zhang Chi , Mao Guangzhi , Huang Long , Wang Chengshe , Fan Shuli , Yu Shuxun
Published: December 2016

Fiber quality is one of the most important agronomic traits of cotton, and understanding the genetic basis of its target traits will accelerate improvements to cotton fiber quality. In this study, a panel comprising 355 upland cotton accessions was used to perform genome-wide association studies (GWASs) of five fiber quality traits in four environments. A total of 16, 10 and 7 SNPs were associated with fiber length (FL), fiber strength (FS) and fiber uniformity (FU), respectively, based on the mixed linear model (MLM). Most importantly, two major genomic regions (MGR1 and MGR2) on chromosome Dt7 and four potential candidate genes for FL were identified. Analyzing the geographical distribution of favorable haplotypes (FHs) among these lines revealed that two favorable haplotype frequencies (FHFs) were higher in accessions from low-latitude regions than in accessions from high-latitude regions. However, the genetic diversity of lines from the low-latitude regions was lower than the diversity of lines from the high-latitude regions in China. Furthermore, the FHFs differed among cultivars developed during different breeding periods. These results indicate that FHs have undergone artificial selection during upland cotton breeding in recent decades in China and provide a foundation for the further improvement of fiber quality traits.
FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines
Authors: Warrick Joshua I. , Walter Vonn , Yamashita Hironobu , Chung Eunah , Shuman Lauren , Amponsa Vasty Osei , Zheng Zongyu , Chan Wilson , Whitcomb Tiffany L. , Yue Feng , Iyyanki Tejaswi , Kawasawa Yuka I. , Kaag Matthew , Guo Wansong , Raman Jay D. , Park Joo-Seop , DeGraff David J.
Published: December 2016

Discrete bladder cancer molecular subtypes exhibit differential clinical aggressiveness and therapeutic response, which may have significant implications for identifying novel treatments for this common malignancy. However, research is hindered by the lack of suitable models to study each subtype. To address this limitation, we classified bladder cancer cell lines into molecular subtypes using publically available data in the Cancer Cell Line Encyclopedia (CCLE), guided by genomic characterization of bladder cancer by The Cancer Genome Atlas (TCGA). This identified a panel of bladder cancer cell lines which exhibit genetic alterations and gene expression patterns consistent with luminal and basal molecular subtypes of human disease. A subset of bladder cancer cell lines exhibit in vivo histomorphologic patterns consistent with luminal and basal subtypes, including papillary architecture and squamous differentiation. Using the molecular subtype assignments, and our own RNA-seq analysis, we found overexpression of GATA3 and FOXA1 cooperate with PPARɣ activation to drive transdifferentiation of a basal bladder cancer cells to a luminial phenotype. In summary, our analysis identified a set of human cell lines suitable for the study of molecular subtypes in bladder cancer, and furthermore indicates a cooperative regulatory network consisting of GATA3, FOXA1, and PPARɣ drive luminal cell fate.
Caffeine prevents kidney stone formation by translocation of apical surface annexin A1 crystal-binding protein into cytoplasm: In vitro evidence
Authors: Peerapen Paleerath , Thongboonkerd Visith
Published: December 2016

Recent large 3 cohorts have shown that caffeinated beverage consumption was associated with lower risk of kidney stone disease. However, its protective mechanisms remained unknown and had not been previously investigated. We thus evaluated protective effects of caffeine (1 μM–10 mM) on calcium oxalate monohydrate (COM) kidney stone formation, using crystallization, crystal growth, cell-crystal adhesion, Western blotting, and immunofluorescence assays. The results showed that caffeine reduced crystal number but, on the other hand, increased crystal size, resulting in unchanged crystal mass, consistent with crystal growth that was not affected by caffeine. However, caffeine significantly decreased crystal-binding capacity of MDCK renal tubular cells in a dose-dependent manner. Western blotting and immunofluorescence study of COM crystal-binding proteins revealed significantly decreased level of annexin A1 on apical surface and its translocation into cytoplasm of the caffeine-treated cells, but no significant changes in other COM crystal-binding proteins (annexin A2, α-enolase, HSP70, and HSP90) were observed. Moreover, caffeine decreased intracellular [Ca2+] but increased [Ca2+] secretory index. Taken together, our findings showed an in vitro evidence of the protective mechanism of caffeine against kidney stone formation via translocation of annexin A1 from apical surface into cytoplasm to reduce the crystal-binding capacity of renal tubular epithelial cells.
Endogenous testosterone is associated with lower amygdala reactivity to angry faces and reduced aggressive behavior in healthy young women
Authors: Buades-Rotger Macià , Engelke Christin , Beyer Frederike , Keevil Brian G. , Brabant Georg , Krämer Ulrike M.
Published: December 2016

Testosterone and cortisol have been proposed to influence aggressive behavior by altering the neural processing of facial threat signals. However, this has not been investigated in direct social interactions. Here, we explored the joint impact of testosterone, cortisol, and brain reactivity to anger expressions on women’s reactive aggression in the Social Threat Aggression Paradigm (STAP). The STAP is a competitive reaction time task in which the purported opponent displays either an angry or a neutral facial expression at the beginning of each trial and delivers increasingly loud sound blasts to the participants, successfully provoking them. Strikingly, salivary testosterone at scan-time was negatively related to both aggression and basolateral amygdala (BLA) reactivity to angry faces, whereas cortisol had no effect. When the opponent looked angry, BLA-orbitofrontal coupling was reduced, and BLA reactivity was positively related to aggression. The latter relationship was fully mediated by bilateral superior temporal gyrus (STG) activation. Our results thus support previous neurobiological models of aggression, and extend them by demonstrating that fast amygdala responses to threat modulate STG activity in order to favor aggressive retaliation. Furthermore, our study agrees with recent evidence underscoring a fear-reducing and strategically prosocial effect of testosterone on human social behavior.
Exploring the coordination change of vanadium and structure transformation of metavanadate MgV2O6 under high pressure
Authors: Tang Ruilian , Li Yan , Xie Shengyi , Li Nana , Chen Jiuhua , Gao Chunxiao , Zhu Pinwen , Wang Xin
Published: December 2016

Raman spectroscopy, synchrotron angle-dispersive X-ray diffraction (ADXRD), first-principles calculations, and electrical resistivity measurements were carried out under high pressure to investigate the structural stability and electrical transport properties of metavanadate MgV2O6. The results have revealed the coordination change of vanadium ions (from 5+1 to 6) at around 4 GPa. In addition, a pressure-induced structure transformation from the C2/m phase to the C2 phase in MgV2O6 was detected above 20 GPa, and both phases coexisted up to the highest pressure. This structural phase transition was induced by the enhanced distortions of MgO6 octahedra and VO6 octahedra under high pressure. Furthermore, the electrical resistivity decreased with pressure but exhibited different slope for these two phases, indicating that the pressure-induced structural phase transitions of MgV2O6 was also accompanied by the obvious changes in its electrical transport behavior.
A New SAR Image Segmentation Algorithm for the Detection of Target and Shadow Regions
Authors: Huang Shiqi , Huang Wenzhun , Zhang Ting
Published: December 2016

The most distinctive characteristic of synthetic aperture radar (SAR) is that it can acquire data under all weather conditions and at all times. However, its coherent imaging mechanism introduces a great deal of speckle noise into SAR images, which makes the segmentation of target and shadow regions in SAR images very difficult. This paper proposes a new SAR image segmentation method based on wavelet decomposition and a constant false alarm rate (WD-CFAR). The WD-CFAR algorithm not only is insensitive to the speckle noise in SAR images but also can segment target and shadow regions simultaneously, and it is also able to effectively segment SAR images with a low signal-to-clutter ratio (SCR). Experiments were performed to assess the performance of the new algorithm on various SAR images. The experimental results show that the proposed method is effective and feasible and possesses good characteristics for general application.
Unified rheology of vibro-fluidized dry granular media: From slow dense flows to fast gas-like regimes
Authors: Gnoli Andrea , Lasanta Antonio , Sarracino Alessandro , Puglisi Andrea
Published: December 2016

Granular media take on great importance in industry and geophysics, posing a severe challenge to materials science. Their response properties elude known soft rheological models, even when the yield-stress discontinuity is blurred by vibro-fluidization. Here we propose a broad rheological scenario where average stress sums up a frictional contribution, generalizing conventional μ(I)-rheology, and a kinetic collisional term dominating at fast fluidization. Our conjecture fairly describes a wide series of experiments in a vibrofluidized vane setup, whose phenomenology includes velocity weakening, shear thinning, a discontinuous thinning transition, and gaseous shear thickening. The employed setup gives access to dynamic fluctuations, which exhibit a broad range of timescales. In the slow dense regime the frequency of cage-opening increases with stress and enhances, with respect to μ(I)-rheology, the decrease of viscosity. Diffusivity is exponential in the shear stress in both thinning and thickening regimes, with a huge growth near the transition.
Piezoelectric polymer gated OFET: Cutting-edge electro-mechanical transducer for organic MEMS-based sensors
Authors: Thuau Damien , Abbas Mamatimin , Wantz Guillaume , Hirsch Lionel , Dufour Isabelle , Ayela Cédric
Published: December 2016

The growth of micro electro-mechanical system (MEMS) based sensors on the electronic market is forecast to be invigorated soon by the development of a new branch of MEMS-based sensors made of organic materials. Organic MEMS have the potential to revolutionize sensor products due to their light weight, low-cost and mechanical flexibility. However, their sensitivity and stability in comparison to inorganic MEMS-based sensors have been the major concerns. In the present work, an organic MEMS sensor with a cutting-edge electro-mechanical transducer based on an active organic field effect transistor (OFET) has been demonstrated. Using poly(vinylidenefluoride/trifluoroethylene) (P(VDF-TrFE)) piezoelectric polymer as active gate dielectric in the transistor mounted on a polymeric micro-cantilever, unique electro-mechanical properties were observed. Such an advanced scheme enables highly efficient integrated electro-mechanical transduction for physical and chemical sensing applications. Record relative sensitivity over 600 in the low strain regime (<0.3%) was demonstrated, which represents a key-step for the development of highly sensitive all organic MEMS-based sensors.
Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome
Authors: Zhao Na , Han Dong , Liu Haochen , Li Yue , Wong Sing-Wai , Cao Zhengyi , Xu Jian , Zhang Xiaowei , Cai Tao , Wang Yixiang , Feng Hailan
Published: December 2016

The homeodomain transcription factor distal-less homeobox 3 gene (DLX3) is required for hair, tooth and skeletal development. DLX3 mutations have been found to be responsible for Tricho-Dento-Osseous (TDO) syndrome, characterized by kinky hair, thin-pitted enamel and increased bone density. Here we show that the DLX3 mutation (c.533 A>G; Q178R) attenuates osteogenic potential and senescence of bone mesenchymal stem cells (BMSCs) isolated from a TDO patient, providing a molecular explanation for abnormal increased bone density. Both DLX3 mutations (c.533 A>G and c.571_574delGGGG) delayed cellular senescence when they were introduced into pre-osteoblastic cells MC3T3-E1. Furthermore, the attenuated skeletal aging and bone loss in DLX3 (Q178R) transgenic mice not only reconfirmed that DLX3 mutation (Q178R) delayed cellular senescence, but also prevented aging-mediated bone loss. Taken together, these results indicate that DLX3 mutations act as a loss of function in senescence. The delayed senescence of BMSCs leads to increased bone formation by compensating decreased osteogenic potentials with more generations and extended functional lifespan. Our findings in the rare human genetic disease unravel a novel mechanism of DLX3 involving the senescence regulation of bone formation.
Synthesis of end-functionalized glycopolymers containing α(2,8) disialic acids via π-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7
Authors: Ohira Shuichi , Yasuda Yu , Tomita Ikuyoshi , Kitajima Ken , Takahashi Takashi , Sato Chihiro , Tanaka Hiroshi
Published: December 2016

The polymerization of an allene glycomonomer efficiently provided glycopolymer possessing α(2,8) disialic acids with narrow PDI.
Developing high-performance small molecule organic solar cells via a large planar structure and an electron-withdrawing central unit
Authors: Zhang Hongtao , Liu Yongtao , Sun Yanna , Li Miaomiao , Kan Bin , Ke Xin , Zhang Qian , Wan Xiangjian , Chen Yongsheng
Published: December 2016

We designed and synthesized a new small molecule donor material named DR3TBDD using an electron-withdrawing unit BDD as the central building block. A PCE of 9.53% with a highVocof around 1 V was achieved.
Synthesis of organosilicon derivatives of [1]benzothieno[3,2-b][1]-benzothiophene for efficient monolayer Langmuir–Blodgett organic field effect transistors
Authors: Borshchev O. V. , Sizov A. S. , Agina E. V. , Bessonov A. A. , Ponomarenko S. A.
Published: December 2016

The first synthesis of organosilicon derivatives of dialkyl[1]benzothieno[3,2-b][1]-benzothiophene (BTBT) capable of forming a semiconducting monolayer at the water–air interface is reported.
Mesoporous stilbene-based lanthanide metal organic frameworks: synthesis, photoluminescence and radioluminescence characteristics
Authors: Mathis II Stephan R. , Golafale Saki T. , Bacsa John , Steiner Alexander , Ingram Conrad W. , Doty F. Patrick , Auden Elizabeth , Hattar Khalid
Published: December 2016

Mesoporous non-interpenetrating stilbene-based lanthanide metal organic frameworks exhibits photo and radioluminescence behavior.
Isolation, structure and magnetic properties of two novel core–shell 3d–4f heterometallic nanoscale clusters
Authors: Lin Qingfang , Zhang Yu , Cheng Weiwei , Liu Ying , Xu Yan
Published: December 2016

Two novel core–shell Ln–Ni (Ln = Nd, Pr) nanosized clusters exhibit discrete dumbbell-shaped and bowknot-like architecture.
Selective synthesis of iridium(iii)-derived molecular Borromean rings, [2]catenane and ring-in-ring macrocycles via coordination-driven self-assembly
Authors: Singh Nem , Kim Dongwook , Kim Dong Hwan , Kim Eun-Hee , Kim Hyunuk , Lah Myoung Soo , Chi Ki-Whan
Published: December 2016

Unprecedented iridium(iii) derived molecular Borromean rings, 2[catenane] and ring-in-ring metallacycles were synthesizedviacoordination driven self-assembly using an iridium(iii)-based acceptor and dipyridyl donors.
Is the rapid initial performance loss of Fe/N/C non precious metal catalysts due to micropore flooding?
Authors: Choi Ja-Yeon , Yang Lijun , Kishimoto Takeaki , Fu Xiaogang , Ye Siyu , Chen Zhongwei , Banham Dustin
Published: December 2016

The instability of Fe/N/C non-precious metal catalysts is still not fully understood, and must be overcome before these catalysts can be commercialized.
Photocatalytic H2 production using a hybrid assembly of an [FeFe]-hydrogenase model and CdSe quantum dot linked through a thiolato-functionalized cyclodextrin
Authors: Cheng Minglun , Wang Mei , Zhang Shuai , Liu Fengyuan , Yang Yong , Wan Boshun , Sun Licheng
Published: December 2016

It is a great challenge to develop iron-based highly-efficient and durable catalytic systems for the hydrogen evolution reaction (HER) by understanding and learning from [FeFe]-hydrogenases. Here we report photocatalytic H2 production by a hybrid assembly of a sulfonate-functionalized [FeFe]-hydrogenase mimic (1) and CdSe quantum dot (QD), which is denoted as 1/β-CD-6-S–CdSe (β-CD-6-SH = 6-mercapto-β-cyclodextrin). In this assembly, thiolato-functionalized β-CD acts not only as a stabilizing reagent of CdSe QDs but also as a host compound for the diiron catalyst, so as to confine CdSe QDs to the space near the site of diiron catalyst. In addition, another two reference systems comprising MAA–CdSe QDs (HMAA = mercaptoacetic acid) and 1 in the presence and absence of β-CD, denoted as 1/β-CD/MAA–CdSe and 1/MAA–CdSe, were studied for photocatalytic H2 evolution. The influences of β-CD and the stabilizing reagent β-CD-6-S− on the stability of diiron catalyst, the fluorescence lifetime of CdSe QDs, the apparent electron transfer rate, and the photocatalytic H2-evolving efficiency were explored by comparative studies of the three hybrid systems. The 1/β-CD-6-S–CdSe system displayed a faster apparent rate for electron transfer from CdSe QDs to the diiron catalyst compared to that observed for MAA–CdSe-based systems. The total TON for visible-light driven H2 evolution by the 1/β-CD-6-S–CdSe QDs in water at pH 4.5 is about 2370, corresponding to a TOF of 150 h−1 in the initial 10 h of illumination, which is 2.7- and 6.6-fold more than the amount of H2 produced from the reference systems 1/β-CD/MAA–CdSe and 1/MAA–CdSe. Additionally, 1/β-CD-6-S–CdSe gave 2.4–5.1 fold enhancement in the apparent quantum yield and significantly improved the stability of the system for photocatalytic H2 evolution.
Evaluation of clinical safety and beneficial effects of stachyose-enriched α-galacto-oligosaccharides on gut microbiota and bowel function in humans
Authors: Li Ting , Lu Xinshan , Yang Xingbin
Published: December 2016

This is the first study providing clinical bases for developing DSG as a novel and safe agent against functional constipation.
Optimization of distances between the target surface and focal point on spatially confined laser-induced breakdown spectroscopy with a cylindrical cavity
Authors: Guo Jin , Shao Junfeng , Wang Tingfeng , Zheng Changbin , Chen Anmin , Jin Mingxing
Published: December 2016

The spatial confinement effect in laser-induced plasma with different distances between the target surface and focal point is investigated by optical emission spectroscopy.
Plasma free reversible and irreversible microfluidic bonding
Authors: Chu M. , Nguyen T. T. , Lee E. K. , Morival J. L. , Khine M.
Published: December 2016

We demonstrate a novel bonding process that allows for facile multilayer microfluidic chip fabrication and is compatible with cell micropatterning.
Three-dimensional cavity nanoantennas with resonant-enhanced surface plasmons as dynamic color-tuning reflectors
Authors: Fan J. R. , Wu W. G. , Chen Z. J. , Zhu J. , Li J.
Published: December 2016

Plasmonic cavity nanoantennas are designed to support multiple narrowband selective and continuously tunable reflection, which consequently produce vibrant reflective colors.
Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids
Authors: Zhao Hui , Jiang Yanhong , Tian Yuan , Yang Dan , Qin Xuan , Li Zigang
Published: December 2016

Physicochemical properties including hydrophobicity and isoelectric point are the driving forces for cellular uptake and nucleus translocation of stabilized helices.
Metal-deposited bismuth oxyiodide nanonetworks with tunable enzyme-like activity: sensing of mercury and lead ions
Authors: Hsu Chia-Lun , Lien Chia-Wen , Harroun Scott G. , Ravindranath Rini , Chang Huan-Tsung , Mao Ju-Yi , Huang Chih-Ching
Published: December 2016

The enzyme-like activity of bismuth oxyiodide nanonetworks are tunable by in situ deposition with metal or metal oxide nanoparticles and the doped nanonetworks can selective detect Hg2+ and Pb2+ ions.
Fe-Catalyzed oxidative spirocyclization of N-arylpropiolamides with silanes and TBHP involving the formation of C–Si bonds
Authors: Wu Li-Jun , Tan Fang-Lin , Li Meng , Song Ren-Jie , Li Jin-Heng
Published: December 2016

A new iron-catalyzed oxidative spirocyclization of N-arylpropiolamides with silanes and TBHP leading to 3-silyl spiro[4,5]trienones is presented, which offers a practical route to introduction of silicon-centered radicals across the C–C triple bonds.
Interfacing neurons on carbon nanotubes covered with diamond
Authors: Seyock Silke , Maybeck Vanessa , Scorsone Emmanuel , Rousseau Lionel , Hébert Clément , Lissorgues Gaëlle , Bergonzo Philippe , Offenhäusser Andreas
Published: December 2016

Investigation of the interface and needed adhesion surface for neuronal cells on carbon nanotubes covered with diamond.
Highly efficient magnetic hyperthermia ablation of tumors using injectable polymethylmethacrylate–Fe3O4
Authors: Ling Yi , Tang Xiuzhen , Wang Fengjuan , Zhou Xiaohan , Wang Ronghui , Deng Liming , Shang Tingting , Liang Bing , Li Pan , Ran Haitao , Wang Zhigang , Hu Bing , Li Chunhong , Zuo Guoqing , Zheng Yuanyi
Published: December 2016

Magnetic hyperthermia is a promising minimally invasive technique for tumor therapy which has drawn much attention.
G-Quadruplex DNA-binding quaternary alkaloids from Tylophora atrofolliculata
Authors: Chen Cheng-Yu , Bai Li-Ping , Ke Zhuo-Feng , Liu Yan , Wang Jing-Rong , Jiang Zhi-Hong
Published: December 2016

Quaternary alkaloids from T. atrofolliculata with human telomeric DNA G-quadruplex binding capacity.
Role of multipolar plasmon resonances during surface-enhanced Raman spectroscopy on Au micro-patches
Authors: Dowd Annette , Geisler Mathias , Zhu Shaoli , Wood Michelle L. , Cortie Michael B.
Published: December 2016

Large more reproducibly fabricated microstructures can also provide significant Raman signal enhancementviausually neglected multipolar plasmon resonances.
A metabolomics approach for predicting the response to intravenous iron therapy in peritoneal dialysis patients with anemia
Authors: Wu Qiong , Lai Xue-li , Zhao Hong-xia , Zhu Zhen-yu , Hong Zhan-ying , Guo Zhi-yong , Chai Yi-feng
Published: December 2016

Anemia is an almost universal complication of chronic kidney disease (CKD), and nearly all patients with end-stage renal disease (ESRD) and approximately 70% of those with earlier stages of CKD receive treatment for anemia.
Self-immolative polymers as novel pH-responsive gate keepers for drug delivery
Authors: Gisbert-Garzaran M. , Lozano D. , Vallet-Regí M. , Manzano M.
Published: December 2016

A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented.
Retraction: Selective uptake of uranium, plutonium and americium on hydrogen titanate nanotubes
Authors: Banerjee Chayan , Dudwadkar Nilesh , Chandra Tripathi Subhash , Gandhi Pritam Maniklal , Kaushik Chetan Prakash , Chaterjee Sriparna , Ayyub Pushan , Tyagi Avesh Kumar
Published: December 2016

Retraction of ‘Selective Uptake of Uranium, Plutonium and Americium on Hydrogen Titanate Nanotubes’ by Chayan Banerjee et al., RSC Adv., 2014, DOI: 10.1039/c3ra42548g.
CO/O2 assisted oxidative carbon–carbon and carbon–heteroatom bond cleavage for the synthesis of oxosulfonates from DMSO and olefins
Authors: Shao Ailong , Gao Meng , Chen Songtao , Wang Tao , Lei Aiwen
Published: December 2016

Selective carbon–carbon and carbon–heteroatom bond cleavage was achieved in a one reaction system.
Electrospun PVDF–TiO2 with tuneable TiO2 crystal phases: synthesis and application in photocatalytic redox reactions
Authors: Tan Jeannie Z. Y. , Nursam Natalita M. , Xia Fang , Truong Yen Bach , Kyratzis Ilias Louis , Wang Xingdong , Caruso Rachel A.
Published: December 2016

The TiO2 crystal phase composition and microstructure of electrospun PVDF–TiO2 membranes affected the photocatalytic reduction of CO2.
A multi-aromatic hydrocarbon unit induced hydrophobic metal–organic framework for efficient C2/C1 hydrocarbon and oil/water separation
Authors: Zhang Minghui , Xin Xuelian , Xiao Zhenyu , Wang Rongming , Zhang Liangliang , Sun Daofeng
Published: December 2016

A highly hydrophobic Cu(ii) MOF (UPC-21) was synthesized through a newly developed “diauxic growth” strategy. The multi-aromatic hydrocarbon units in the framework are responsible for hydrophobic character of UPC-21. Its application on water purification and oil/water separation was studied for the first time.
Easily accessible conjugated pyrene sulfonates as cathode interfacial materials for polymer solar cells
Authors: Zhou Lingyu , Yu Wei , Yu Shuwen , Fu Ping , Guo Xin , Li Can
Published: December 2016

Two easily accessible water/alcohol-soluble pyrene sulfonate small molecules were used as cathode interfacial materials for efficient polymer solar cells.
A novel device structure for a low-cost Li–S battery
Authors: Liu Zhen , Zheng Xiang , Yuan Ning-yi , Ding Jian-ning
Published: December 2016

A novel device structure for high performance Li–S batteries was investigated.
Competition and promotion of different mesophases in a series of novel unsymmetrical discotic dimers via subtle modification of spacers and peripheral side chains
Authors: Hao Xingtian , Zhang Chunxiu , Wang Jianchuang , Zhang Wanying , Hong Feng , Zhang Shuaifeng , Zhang Ao , Yang Huanzhi , Zhang Zhenhu , Wang Yifei , Wu Hao , Pu Jialing
Published: December 2016

The superlattice structure of the columnar plastic phase in unsymmetrical triphenylene-based dimers.
Mapping the kinetic Sunyaev-Zel’dovich effect toward MACS J0717.5+3745 with NIKA
Authors: Adam R. , Bartalucci I. , Pratt G. W. , Ade P. , André P. , Arnaud M. , Beelen A. , Benoît A. , Bideaud A. , Billot N. , Bourdin H. , Bourrion O. , Calvo M. , Catalano A. , Coiffard G. , Comis B. , D’Addabbo A. , De Petris M. , Démoclès J. , Désert F.-X. , Doyle S. , Egami E. , Ferrari C. , Goupy J. , Kramer C. , Lagache G. , Leclercq S. , Macías-Pérez J.-F. , Maurogordato S. , Mauskopf P. , Mayet F. , Monfardini A. , Mroczkowski T. , Pajot F. , Pascale E. , Perotto L. , Pisano G. , Pointecouteau E. , Ponthieu N. , Revéret V. , Ritacco A. , Rodriguez L. , Romero C. , Ruppin F. , Schuster K. , Sievers A. , Triqueneaux S. , Tucker C. , Zemcov M. , Zylka R.
Published: December 2016

Measurement of the gas velocity distribution in galaxy clusters provides insight into the physics of mergers, through which large scale structures form in the Universe. Velocity estimates within the intracluster medium (ICM) can be obtained via the Sunyaev-Zel’dovich (SZ) effect, but its observation is challenging both in term of sensitivity requirement and control of systematic effects, including the removal of contaminants. In this paper we report resolved observations, at 150 and 260 GHz, of the SZ effect toward the triple merger MACS J0717.5+3745 (z= 0.55), using data obtained with the NIKA camera at the IRAM 30 m telescope. Assuming that theSZ signal is the sum of a thermal (tSZ) and a kinetic (kSZ) component and by combining the two NIKA bands, we extract for the first time a resolved map of the kSZ signal in a cluster. The kSZ signal is dominated by a dipolar structure that peaks at −5.1 and + 3.4σ, corresponding to two subclusters moving respectively away and toward us and coincident with the cold dense X-ray core and a hot region undergoing a major merging event. We model the gas electron density and line-of-sight velocity of MACS J0717.5+3745 as four subclusters. Combining NIKA data with X-ray observations fromXMM-NewtonandChandra, we fit this model to constrain the gas line-of-sight velocity of each component, and we also derive, for the first time, a velocity map from kSZ data (i.e. that is model-dependent). Our results are consistent with previous constraints on the merger velocities, and thanks to the high angular resolution of our data, we are able to resolve the structure of the gas velocity. Finally, we investigate possible contamination and systematic effects with a special care given to radio and submillimeter galaxies. Among the sources that we detect with NIKA, we find one which is likely to be a high redshift lensed submillimeter galaxy.
Some classes of rational functions for pictures
Authors: Mráz František , Otto Friedrich , Průša Daniel
Published: December 2016

With the aid of homogeneous morphisms, we turn the deterministic two-dimensional two-way
ordered restarting automaton and its extended variant into devices that compute
transductions of pictures, and we study the resulting classes of transductions in
detail.
Notaufnahmen: Hamburg plant Revolutionäres
Authors: Gaede Kirsten
Published: December 2016

Statt 21 Notaufnahmen nur noch 4 Zentren – an diesem Ziel arbeiten die Krankenhäuser und die Kassenärztliche Vereinigung in Hamburg auf Hochtouren, unter Einbindung der Gesundheitsbehörde von Cornelia Prüfer-Storcks. Dort sollen dann niedergelassene Ärzte die Patientenströme lenken. Ab 2017 soll dazu in Hamburg-Harburg ein Pilotprojekt starten, berichtet das "Hamburger Abendblatt".
Krankenhausstrukturgesetz: Die To-do-Liste des G-BA
Authors: Paquet Robert
Published: December 2016

Mit dem Krankenhausstrukturgesetz kommt auf den Gemeinsamen Bundesausschuss (G-BA) viel Arbeit zu. Viel davon ist termingebunden. Hier bieten wir Ihnen eine systematische und umfassende Übersicht aller Aufgaben, die der G-BA 2017 in puncto Kliniken zu bewältigen hat.
Textilien: Aufgabe eines Statussymbols
Authors: Mewis Dirk
Published: December 2016

Hunderttausende Patienten stecken sich jedes Jahr in deutschen Krankenhäusern mit Keimen an. Die Krankheitserreger haften oft auch auf der Klinikkleidung. Ein ausgeprägtes Hygienebewusstsein und präventive Maßnahmen können das Infektionsrisiko senken.
Rückblicke und Ausblicke zum Jahreswechsel: Gutes tun, darüber reden und netzwerken
Authors: Thalmayr Maria
Published: December 2016

Kommunikation wird für den ÖVKT 2017 zentrales Thema sein. Engere Netzwerke mit Forschung, Industrie, IT-Leitern, anderen Stakeholdern im Gesundheitswesen und internationalen Partnern zu knüpfen, verfolgt zusätzlich das Kernziel des Verbandes, Gesundheitseinrichtungen eine innovative, sichere und effiziente technische Performance anzubieten – mithilfe von maximalem Wissen.
Apparatus for measuring pressure-driven transport through channels at high Knudsen numbers
Authors: Karakitsiou S. , Holst B. , Hoffmann A. C.
Published: December 2016

The pressure-driven gas flow through micro- and nano-porous structures is particularly interesting for innovative technologies such as microelectromechanical and nano-mechanical-electrical systems. The classical continuum assumption breaks down for rarefied flow through channels with a characteristic dimension comparable to the mean free path of the gas. Theories based on molecular interactions have been formulated to predict the flow at high Knudsen numbers. Measuring rarefied gas flow experimentally is a challenge since only a few studies have been able to determine flowrates in the molecular flow regime. Here we present the design of an experimental apparatus, which can be used to measure the flow of gases through nano- and microscale channels in the flow regimes where molecular effects are critical. The equations used to design the apparatus are given, focusing on the slip and transition flow regimes (together sometimes called “Intermediate flow regime”). A channel with a diameter of 325 μm ± 5μm and a length of 2 mm was tested experimentally with the apparatus for a wide range of Knudsen numbers (10−2 < Kn < 1 × 105) demonstrating its suitability through the slip and transition regime (2.23 × 10−2 < Kn < 2.26).
Improvements to an ion orbit loss calculation in the tokamak edge
Authors: Wilks T. M. , Stacey W. M.
Published: December 2016

An existing model of collisionless particle, momentum, and energy ion orbit loss from the edge region of a diverted tokamak plasma has been extended. The extended ion orbit loss calculation now treats losses of both thermal ions and fast neutral beam injection ions and includes realistic flux surface and magnetic field representations, particles returning to the plasma from the scrape off layer, and treatment of x-transport and x-loss. More realistic flux surface geometry allows the intrinsic rotation calculation to predict a peaking in the profile closer to the separatrix, which is consistent with experiment; and particle tracking calculations reveal a new mechanism of “x-transport pumping,” which predicts larger ion losses when coupling conventional ion orbit loss and x-loss mechanisms, though still dominated by conventional ion orbit loss. Sensitivity to these ion orbit loss model enhancements is illustrated by fluid predictions of neoclassical rotation velocities and radial electric field profiles, with and without the enhancements.
Positron and electron scattering by glycine and alanine: Shape resonances and methylation effect
Authors: Nunes Fernanda B. , Bettega Márcio H. F. , Sanchez Sergio d’Almeida
Published: December 2016

We report integral cross sections (ICSs) for both positron and electron scattering by glycine and alanine amino acids. These molecules differ only by a methyl group. We computed the scattering cross sections using the Schwinger multichannel method for both glycine and alanine in different levels of approximation for both projectiles. The alanine ICSs are greater in magnitude than the glycine ICSs for both positron and electron scattering, probably due to the larger size of the molecule. In electron scattering calculations, we found two resonances for each molecule. Glycine presents one at 1.8 eV, and another centered at around 8.5 eV, in the static-exchange plus polarization (SEP) approximation. The ICS for alanine shows one resonance at 2.5 eV and another at around 9.5 eV, also in SEP approximation. The results are in good agreement with most of the data present in the literature. The comparison of the electron scattering ICSs for both molecules indicates that the methylation of glycine destabilizes the resonances, shifting them to higher energies.
Actuation performances of anisotropic gels
Authors: Nardinocchi P. , Teresi L.
Published: December 2016

We investigated the actuation performances of anisotropic gels driven by mechanical and chemical stimuli, in terms of both deformation processes and stroke–curves, and distinguished between the fast response of gels before diffusion starts and the asymptotic response attained at the steady state. We also showed as the range of forces that an anisotropic hydrogel can exert when constrained is especially wide; indeed, changing fiber orientation allows us to induce shear as well as transversely isotropic extensions.
Phase behavior of patchy spheroidal fluids
Authors: Carpency T. N. , Gunton J. D. , Rickman J. M.
Published: December 2016

We employ Gibbs-ensemble Monte Carlo computer simulation to assess the impact of shape anisotropy and particle interaction anisotropy on the phase behavior of a colloidal (or, by extension, protein) fluid comprising patchy ellipsoidal particles, with an emphasis on critical behavior. More specifically, we obtain the fluid-fluid equilibrium phase diagram of hard prolate ellipsoids having Kern-Frenkel surface patches under a variety of conditions and study the critical behavior of these fluids as a function of particle shape parameters. It is found that the dependence of the critical temperature on aspect ratio for particles having the same volume can be described approximately in terms of patch solid angles. In addition, ordering in the fluid that is associated with particle elongation is also found to be an important factor in dictating phase behavior.