bluuebunny/crossref_metadata_2025 huggingface dataset:
E-Textile Metamaterials: Stop Band Pass Filter
Authors: Moradi Bahareh , Fernández-García Raul , Gali Ignacio Gil
Published: November 2021

In this paper, the utilization of common fabrics for the manufacturing of e-textile metamaterial is investigated. The proposed design is based on a transmission line loaded with split-ring resonators (SRRs) on a cotton substrate for filter signal application. The proposed design provides a stop band between 2.7 GHz and 4.7 GHz, considering a four stage SRR topology. Experimental results showed stop band levels higher than −30 dB for the proposed compact embroidered metamaterial e-textiles. The validated results confirmed embroidery as a useful technique to obtain customized electromagnetic filter properties, such as transmitted signal filtering and control, on wearable tech device applications.
An Explainable Approach Based on Emotion and Sentiment Features for Detecting People with Mental Disorders on Social Networks
Authors: Gallegos Salazar Leslie Marjorie , Loyola-González Octavio , Medina-Pérez Miguel Angel
Published: November 2021

Mental disorders are a global problem that widely affects different segments of the population. Diagnosis and treatment are difficult to obtain, as there are not enough specialists on the matter, and mental health is not yet a common topic among the population. The computer science field has proposed some solutions to detect the risk of depression, based on language use and data obtained through social media. These solutions are mainly focused on objective features, such as n-grams and lexicons, which are complicated to be understood by experts in the application area. Hence, in this paper, we propose a contrast pattern-based classifier to detect depression by using a new data representation based only on emotion and sentiment analysis extracted from posts on social media. Our proposed feature representation contains 28 different features, which are more understandable by specialists than other proposed representations. Our feature representation jointly with a contrast pattern-based classifier has obtained better classification results than five other combinations of features and classifiers reported in the literature. Our proposal statistically outperformed the Random Forest, Naive Bayes, and AdaBoost classifiers using the parser-tree, VAD (Valence, Arousal, and Dominance) and Topics, and Bag of Words (BOW) representations. It obtained similar statistical results to the logistic regression models using the Ensemble of BOWs and Handcrafted features representations. In all cases, our proposal was able to provide an explanation close to the language of experts, due to the mined contrast patterns.
A New Beam Finite Element for Static Bending Analysis of Slender Transversely Cracked Beams on Two-Parametric Soils
Authors: Skrinar Matjaž , Uranjek Mojmir , Peruš Iztok , Imamović Denis
Published: November 2021

This paper derives an original finite element for the static bending analysis of a transversely cracked uniform beam resting on a two-parametric elastic foundation. In the simplified computational model based on the Euler–Bernoulli theory of small displacements, the crack is represented by a linear rotational spring connecting two elastic members. The derivations of approximate transverse displacement functions, stiffness matrix coefficients, and the load vector for a linearly distributed load along the entire beam element are based on novel cubic polynomial interpolation functions, including the second soil parameter. Moreover, all derived expressions are obtained in closed forms, which allow easy implementation in existing finite element software. Two numerical examples are presented in order to substantiate the discussed approach. They cover both possible analytical solution forms that may occur (depending on the problem parameters) from the same governing differential equation of the considered problem. Therefore, several response parameters are studied for each example (with additional emphasis on their convergence) and compared with the corresponding analytical solution, thus proving the quality of the obtained finite element.
The Optimal Performance of the Energy Efficiency of a Pulse Dust Collection System towards Sustainability
Authors: Ho Chun-Ling , Tang Yung-Chih , Chiu Wen-Chih
Published: November 2021

A growing number of manufacturers are realizing cost and environmental benefits through the sustainability of innovation and optimization processes. Based on polluting less and creating less, the study is pursuing sustainability on increasing operational efficiency by reducing costs and waste. Pulse dust collection systems are commonly used filtration equipment in industries and have lots of energy consumption due to running all day. This study is focused on the optimal parameters for energy saving and cost reduction, and the model is represented by the pressure drop of the filter and the residual powder. The characteristic values of the cleaning efficiency and the air permeability reduction are used for MATLAB to analyze the optimization state. This study found that the material of filter elements, the type of dust, the conditions of pulse-jet, and the filtering speed are the factors that affect the operational efficiency. In terms of cost, the pulse interval time in 10 s is the best parameter, and the pulse time does not affect the overall cost of the filter. Considering energy saving, 0.1 s of the pulse time is the best parameter. In addition, a lower dust concentration is a way to improve efficiency for increasing the filter life and reducing cost.
Prediction and Controlling of Auditory Perception in Augmented Environments. A Loudness-Based Dynamic Mixing Technique
Authors: Moustakas Nikolaos , Floros Andreas , Rovithis Emmanouel , Vogklis Konstantinos
Published: November 2021

At the core of augmented reality audio (ARA) technology lies the ARA mix, a process responsible for the assignment of a virtual environment to a real one. Legacy ARA mix models have focused on the natural reproduction of the real environment, whereas the virtual environment is simply mixed through fixed gain methods. This study presents a novel approach of a dynamic ARA mix that facilitates a smooth adaptation of the virtual environment to the real one, as well as dynamic control of the virtual audio engine, by taking into account the inherent characteristics of both ARA technology and binaural auditory perception. A prototype feature extraction technique of auditory perception characteristics through a real-time binaural loudness prediction method was used to upgrade the legacy ARA mix model into a dynamic model, which was evaluated through benchmarks and subjective tests and showed encouraging results in terms of functionality and acceptance.
Free and Forced Wave Motion in a Two-Dimensional Plate with Radial Periodicity
Authors: Manconi Elisabetta , Sorokin Sergey V. , Garziera Rinaldo , Quartaroli Matheus Mikael
Published: November 2021

In many practical engineering situations, a source of vibrations may excite a large and flexible structure such as a ship’s deck, an aeroplane fuselage, a satellite antenna, a wall panel. To avoid transmission of the vibration and structure-borne sound, radial or polar periodicity may be used. In these cases, numerical approaches to study free and forced wave propagation close to the excitation source in polar coordinates are desirable. This is the paper’s aim, where a numerical method based on Floquet-theory and the FE discretision of a finite slice of the radial periodic structure is presented and verified. Only a small slice of the structure is analysed, which is approximated using piecewise Cartesian segments. Wave characteristics in each segment are obtained by the theory of wave propagation in periodic Cartesian structures and Finite Element analysis, while wave amplitude change due to the changes in the geometry of the slice is accommodated in the model assuming that the energy flow through the segments is the same. Forced response of the structure is then evaluated in the wave domain. Results are verified for an infinite isotropic thin plate excited by a point harmonic force. A plate with a periodic radial change of thickness is then studied. Free waves propagation are shown, and the forced response in the nearfield is evaluated, showing the validity of the method and the computational advantage compared to FE harmonic analysis for infinite structures.
Interdisciplinary Urban Tunnel Control within Smart Cities
Authors: Přibyl Ondřej , Přibyl Pavel , Svítek Miroslav
Published: November 2021

Nowadays, urban road tunnels are considered to be independent entities within a city. Their interactions with the rest of the city and vice versa are usually not considered and, if they are, are only considered in a limited way (for example, through the nearest traffic controller). Typically, only the traffic parameters and not the environmental impacts are considered. This paper has two major objectives. First, we provide a systemic view on a road urban tunnel. The major focus is on the interfaces between the tunnel and the rest of the city and the way they will be managed. We are providing a tool to take into consideration a sustainable development of a tunnel (i.e., not only traffic flow parameters such as average speed, but also environmental and societal characteristics). This model expresses the actual traffic situation in a monetary form (i.e., cost of congestions). The second objective is to provide a new road urban tunnel control approach that follows the original methodology and systemic view described in the paper. If the tunnel is controlled autonomously, which corresponds to the current state-of-the-art in many cities, the algorithm decides to close it based on only local parameters. However, the proposed new algorithm takes into consideration not only the traffic situation in the tunnel (expressed by the parameter traffic density), but also the actual traffic situation within the city (expressed by its level of service (LOS)). This allows more environmentally, socially and economically sustainable oriented road urban tunnel management. The described algorithm is demonstrated on a specific example of the tunnel complex Blanka in Prague.
Experimental Study on the Heat Transfer Performance of Pump-Assisted Capillary Phase-Change Loop
Authors: Yang Xiaoping , Wang Gaoxiang , Zhang Cancan , Liu Jie , Wei Jinjia
Published: November 2021

To overcome the two-phase flow instability of traditional boiling heat dissipation technologies, a porous wick was used for liquid-vapor isolation, achieving efficient and stable boiling heat dissipation. A pump-assisted capillary phase-change loop with methanol as the working medium was established to study the effect of liquid-vapor pressure difference and heating power on its start-up and steady-state characteristics. The results indicated that the evaporator undergoes four heat transfer modes, including flooded, partially flooded, thin-film evaporation, and overheating. The thin-film evaporation mode was the most efficient with the shortest start-up period. In addition, heat transfer modes were determined by the liquid-vapor pressure difference and power. The heat transfer coefficient significantly improved and the thermal resistance was reduced by increasing liquid-vapor pressure as long as it did not exceed 8 kPa. However, when the liquid-vapor pressure exceeded 8 kPa, its influence on the heat transfer coefficient weakened. In addition, a two-dimensional heat transfer mode distribution diagram concerning both liquid-vapor pressure difference and power was drawn after a large number of experiments. During an engineering application, the liquid-vapor pressure difference can be controlled to maintain efficient thin-film evaporation in order to achieve the optimum heat dissipation effect.
Impact Response of Composite Sandwich Cylindrical Shells
Authors: Reis Paulo N. B. , Coelho Carlos A. C. P. , Navalho Fábio V. P.
Published: November 2021

Nowadays, due to the complexity and design of many advanced structures, cylindrical shells are starting to have numerous applications. Therefore, the main goal of this work is to study the effect of thickness and the benefits of a carbon composite sandwich cylindrical shell incorporating a cork core, compared to a conventional carbon composite cylindrical shell, in terms of the static and impact performances. For this purpose, static and impact tests were carried out with the samples freely supported on curved edges, while straight edges were bi-supported. A significant effect of the thickness on static properties and impact performance was observed. Compared to thinner shells, the failure load on the static tests increased by 237.9% and stiffness by 217.2% for thicker shells, while the restored energy obtained from the impact tests abruptly increased due to the collapse that occurred for the thinner ones. Regarding the sandwich shells, the incorporation of a cork core proved to be beneficial because it promoted an increase in the restored energy of around 44.8% relative to the conventional composite shell. Finally, when a carbon skin is replaced by a Kevlar one (hybridization effect), an improvement in the restored energy of about 20.8% was found. Therefore, it is possible to conclude that numerous industrial applications can benefit from cylindrical sandwiches incorporating cork, and their hybridization with Kevlar fibres should be especially considered when they are subject to impact loads. This optimized lay-up is suggested because Kevlar fibres fail through a series of small fibril failures, while carbon fibres exhibit a brittle collapse.
Effects of 12 Weeks of Strength Training and Gluten-Free Diet on Quality of Life, Body Composition and Strength in Women with Celiac Disease: A Randomized Controlled Trial
Authors: Martínez-Rodríguez Alejandro , Loaiza-Martínez Daniela Alejandra , Sánchez-Sánchez Javier , Rubio-Arias Jacobo A. , Alacid Fernando , Prats-Moya Soledad , Martínez-Olcina María , Yáñez-Sepúlveda Rodrigo , Asencio-Mas Nuria , Marcos-Pardo Pablo J.
Published: November 2021

Celiac disease (CD) is an autoimmune disease characterized by gluten-induced intestinal inflammation. Dietary restrictions and symptoms may have a significant impact on the patient’s quality of life, body composition (BC), and strength. This study was designed to assess the impact of an isocaloric gluten free diet and resistance exercise in women. A total of 28 Spanish women, aged 40 years old or more, took part in a randomized controlled trial. Each group received a different intervention: group 1, gluten-free nutrition plan + exercise (GFD + E); group 2, gluten-free nutrition plan (GFD); group 3, celiac controls (NO-GFD); and group 4, non-celiac controls (CONTROL). The variables studied were quality of life, BC and isometric hand strength. After 12 weeks of intervention, celiac women that followed a gluten-free diet and exercise showed higher scores on the psychological health scale than celiac women without intervention. The women in group 1 were the only ones who presented improvements in BC variables; fat mass, BMI, and fat-free mass. Negative correlations were found between the perception of quality of life and age, however a positive correlation between quality of life and isometric strength test results was found. In addition to a gluten-free diet, resistance training is essential to improve BC, strength, and gastrointestinal symptoms.
Electrically Tunable Perfect Terahertz Absorber Using Embedded Combline Graphene Layer
Authors: Maghoul Amir , Rostami Ali , Barzinjy Azeez Abdullah , Mirtaheri Peyman
Published: November 2021

Graphene is a powerful 2-D matter with the capability of extraordinary transparency, and tunable conductivity is employed in emerging optoelectronics devices. In this article, the design of an electrically tunable graphene-based perfect terahertz absorber is proposed and evaluated numerically. The introduced structure is composed of two graphene layers with a sharp absorption peak in the terahertz band. These graphene layers are combline and stripline separated by the insulator substrate. The position of the absorption peak is tunable on the absorption band by means of manipulation in geometric parameters of the combline graphene layer. Furthermore, the intensity and frequency of the absorption peak can be flexibly modulated by varying Fermi potential of the combline graphene layer, which can be controlled through external DC voltages without the need of changing the geometry of the structure. It is shown that the absorption band can be tuned in the bandwidth from 5 to 15 in terahertz. The findings of this paper can promote a new perspective in designing perfect ribbon absorbers based on graphene properties that can be utilized for future photodetectors, solar cells, and thermal sensors with an absorption intensity above 2 × 105(nm2) with narrow absorption bandwidth of 0.112 THz.
Protective Effect of Siegesbeckia orientalis on Pancreatic β-Cells under High Glucose-Induced Glucotoxicity
Authors: Chang Chi-Chang , Houng Jer-Yiing , Wang Shih-Wei , Hsuan Chin-Feng , Lu Yung-Chuan , Chang Tzu-Hsien , Chen Ya-Ling
Published: November 2021

The glucotoxicity caused by long-term exposure of β-cells to high glucose (HG) conditions may lead to the generation of more reactive oxygen species (ROS), reduce the activity of antioxidant enzymes, cause cell damage and apoptosis, and induce insulin secretion dysfunction. Siegesbeckia orientalis linne is a traditional folk herbal medicine used to treat snake bites, rheumatoid arthritis, allergies, and immune deficiencies. In this study, we evaluated the protective effect of S. orientalis ethanol extract (SOE) on cell death and oxidative stress in RIN-m5f pancreatic β-cells stimulated by two HG concentrations (50–100 mM). In the cell viability assay, SOE could significantly increase the survival rate of pancreatic β-cells under HG-induced conditions. For the oxidative stress induced by HG condition, the treatment of SOE effectively reduced the ROS formation, increased the content of intracellular glutathione, and up-regulated the expression of antioxidant enzymes, catalase, superoxide dismutase, and glutathione peroxidase. As a result, the SOE treatment could decrease the glucotoxicity-mediated oxidative damage on RIN-m5F β-cells. Moreover, SOE had the function of regulating insulin secretion in pancreatic β-cells under different HG-mediated conditions. It could decrease the increasing intracellular insulin secretion under the low glucose concentration to normal level; while increase the decreasing intracellular insulin secretion under the relatively high glucose concentration to normal level. Taken together, this study suggests that SOE has a protective effect on pancreatic β-cells under the HG-stimulated glucotoxic environment.
Automated Ground Truth Generation for Learning-Based Crack Detection on Concrete Surfaces
Authors: Chen Hsiang-Chieh , Li Zheng-Ting
Published: November 2021

This article introduces an automated data-labeling approach for generating crack ground truths (GTs) within concrete images. The main algorithm includes generating first-round GTs, pre-training a deep learning-based model, and generating second-round GTs. On the basis of the generated second-round GTs of the training data, a learning-based crack detection model can be trained in a self-supervised manner. The pre-trained deep learning-based model is effective for crack detection after it is re-trained using the second-round GTs. The main contribution of this study is the proposal of an automated GT generation process for training a crack detection model at the pixel level. Experimental results show that the second-round GTs are similar to manually marked labels. Accordingly, the cost of implementing learning-based methods is reduced significantly because data labeling by humans is not necessitated.
FD-LTDA-MAC: Full-Duplex Unsynchronised Scheduling in Linear Underwater Acoustic Chain Networks
Authors: Ahmed Aliyu , Mitchell Paul D. , Zakharov Yuriy , Morozs Nils
Published: November 2021

In-band full-duplex communication offers significant potential to enhance network performance. This paper presents the full-duplex linear transmit delay allocation MAC (FD-LTDA-MAC) protocol for full-duplex based underwater acoustic chain networks (FD-UACNs) for subsea pipeline monitoring. This incorporates a number of extensions to the LTDA-MAC protocol in order to fully exploit advantages of full-duplex communication to enhance the efficiency of underwater facility monitoring. The protocol uses a greedy optimisation algorithm to derive collision-free packet schedules for delivering data packets to the sink node of the underwater chain network. The purpose of this paper is to show the significant improvement that can be achieved in packet scheduling by exploiting temporal spectrum re-use of an underwater acoustic channel through full-duplex communication. Simulation results show that more efficient packet scheduling and reduced end-to-end packet delays can be achieved in large scale scenarios using FD-LTDA-MAC compared with LTDA-MAC and LTDA-MAC with full-duplex enabled nodes. It can provide much higher monitoring rates for long range underwater pipelines using low cost, mid range, low rate, and low power acoustic modems.
Bibliometric Analysis of Dental Erosion (2011–2020)
Authors: Marqués Martínez Laura , Borrell García Carla , Guinot Barona Clara , Boo Gordillo Paula , García Miralles Esther
Published: November 2021

During the past decade, an increase in the number of studies about dental erosion has been observed. The aim of the present study was to describe the current trends in published scientific articles related to dental erosion between 2011 and 2020. Data of the authors, year and language of publication were analyzed. A bibliometric analysis of the articles published in PubMed was conducted using the MeSH terms (dental erosion) and (tooth erosion) using the Boolean operator OR/AND. A sample of n = 1090 articles published during the past ten years (2011–2020) was obtained. The variables analyzed were the language of the article, the year of publishing, the number of authors, the affiliations of the first and last author and the relationship between them. The countries of origin of the first and last author were ranked according to the number of publications, led by Brazil, the UK, and the USA. During the analysis of the type of article, we observed that 79.4% of all publications were research articles. In recent years, a significant increase in research articles on dental erosion has been observed, especially in Brazil and the UK, with a high number of publications of translational articles in humans and cross-sectional observational studies. The main findings in this article will help researchers, academics and students to characterize scientific results regarding dental erosion, to evaluate management strategies and to identify important topics and issues that will help design future research.
Design of Electrode Placement for Presenting Phosphenes in the Lower Visual Field Based on Electric Field Simulation
Authors: Kanamaru Manami , Tan Phan Xuan , Kamioka Eiji
Published: November 2021

Presenting visual information, called phosphenes, is a critical method for providing information on the position of obstacles for users of walking support tools for the visually impaired. A previous study has established a method for presenting phosphenes to the right, center, and left of the visual field. However, a method for presenting information on the position of obstacles around the feet using phosphenes, which is essential for the visually impaired, has not been clarified. Therefore, in this study, a method for presenting phosphenes in the lower visual field is presented, towards the aim of realizing a safe walking support tool. Electrode placement is proposed in this paper for the presentation of phosphenes to the right, center, and left of the lower visual field based on the electrode placement method used in the previous study, which presents the phosphene in three locations of the visual field. In addition, electric field simulation is performed, focusing on the electric field value on the eyeball surface, in order to observe whether the proposed electrode placement is able to stimulate the intended region. As a result, it is shown that the intended region on the eyeball surface can be stimulated locally with each of the proposed electrode placements.
Magnesium Nanoparticle Synthesis from Powders via Pulsed Laser Ablation in Liquid for Nanocolloid Production
Authors: Nyabadza Anesu , Vázquez Mercedes , Coyle Shirley , Fitzpatrick Brian , Brabazon Dermot
Published: November 2021

Magnesium nanoparticles of various mean diameters (53–239 nm) were synthesised in this study via pulsed laser ablation in liquid (PLAL) from millimetre sized magnesium powders within isopropyl alcohol. It was observed via a 3 × 3 full factorial design of experiments that the processing parameters can control the nanoparticle distribution to produce three size-distribution types (bimodal, skewed and normal). Ablation times of 2, 5, and 25 min where investigated. An ablation time of 2 min produced a bimodal distribution with the other types seen at higher periods of processing. Mg nanoparticle Ultraviolet–Visible spectroscopy (UV–Vis) absorbance at 204 nm increased linearly with increasing ablation time, indicating an increase in nanoparticle count. The colloidal density (mg/mL) generally increased with increasing nanoparticle mean diameter as noted via increasing UV–Vis absorbance. High laser scan speeds (within the studied range of 3000–3500 mm/s) tend to increase the nanoparticle count/yield. For the first time, the effect of scan speed on colloidal density, UV–Vis absorbance and nanoparticle diameter from metallic powder ablation was investigated and is reported herein. The nanoparticles formed dendritic structures after being drop cast on aluminium foil as observed via field emission scanning electron microscope analysis. Dynamic light scattering was used to measure the size of the nanoparticles. Magnesium nanoparticle inks show promise for use in the fabrication conductive tracks or thermal insulation in electronics.
The Fusion of MRI and CT Medical Images Using Variational Mode Decomposition
Authors: Polinati Srinivasu , Bavirisetti Durga Prasad , Rajesh Kandala N V P S , Naik Ganesh R , Dhuli Ravindra
Published: November 2021

In medical image processing, magnetic resonance imaging (MRI) and computed tomography (CT) modalities are widely used to extract soft and hard tissue information, respectively. However, with the help of a single modality, it is very challenging to extract the required pathological features to identify suspicious tissue details. Several medical image fusion methods have attempted to combine complementary information from MRI and CT to address the issue mentioned earlier over the past few decades. However, existing methods have their advantages and drawbacks. In this work, we propose a new multimodal medical image fusion approach based on variational mode decomposition (VMD) and local energy maxima (LEM). With the help of VMD, we decompose source images into several intrinsic mode functions (IMFs) to effectively extract edge details by avoiding boundary distortions. LEM is employed to carefully combine the IMFs based on the local information, which plays a crucial role in the fused image quality by preserving the appropriate spatial information. The proposed method’s performance is evaluated using various subjective and objective measures. The experimental analysis shows that the proposed method gives promising results compared to other existing and well-received fusion methods.
Reduction in Indoor Airborne Endotoxin Concentration by the Use of Air Purifier and Its Relationship with Respiratory Health: A Randomized Crossover Intervention Study
Authors: Yoda Yoshiko , Tamura Kenji , Otani Naruhito , Hasunuma Hideki , Nakayama Shoji F. , Shima Masayuki
Published: November 2021

Endotoxins are biological components of particulate matter that cause adverse respiratory system effects. Recently, air purifiers have been widely used; however, their effects on endotoxins are not fully understood. We conducted a randomized crossover intervention study to evaluate the effects of air purifiers on indoor endotoxins and occupants’ respiratory health. Thirty-two healthy subjects were randomly assigned to two groups; each group spent four weeks using either a true or sham (filter removed) air purifier. Subsequently, the subjects spent an additional four weeks using the alternative air purifier. The indoor endotoxins in fine (PM2.5) and coarse (PM10–2.5) particulate matter were continuously collected, and pulmonary function was tested repeatedly during the study period. Household characteristics were assessed using a questionnaire. The geometric mean of the PM2.5 endotoxin concentrations was 0.13 EU/m3, which was significantly lower with true purifiers compared with sham purifiers, after adjusting for household characteristics (0.17 EU/m3). In addition, the PM2.5 endotoxin concentrations were significantly greater in reinforced concrete houses than in wooden houses. The PM10–2.5 endotoxin concentrations were significantly greater in homes with two or more household members, and in those with pets. No association was found between endotoxin concentration and respiratory health among the subjects.
Blockchain-Aware Distributed Dynamic Monitoring: A Smart Contract for Fog-Based Drone Management in Land Surface Changes
Authors: Khan Abdullah Ayub , Shaikh Zaffar Ahmed , Laghari Asif Ali , Bourouis Sami , Wagan Asif Ali , Ali Ghulam Ali Alias Atif
Published: November 2021

In this paper, we propose a secure blockchain-aware framework for distributed data management and monitoring. Indeed, images-based data are captured through drones and transmitted to the fog nodes. The main objective here is to enable process and schedule, to investigate individual captured entity (records) and to analyze changes in the blockchain storage with a secure hash-encrypted (SH-256) consortium peer-to-peer (P2P) network. The proposed blockchain mechanism is also investigated for analyzing the fog-cloud-based stored information, which is referred to as smart contracts. These contracts are designed and deployed to automate the overall distributed monitoring system. They include the registration of UAVs (drones), the day-to-day dynamic captured drone-based images, and the update transactions in the immutable storage for future investigations. The simulation results show the merit of our framework. Indeed, through extensive experiments, the developed system provides good performances regarding monitoring and management tasks.
Generalized Hypergeometric Function 3F2 Ratios and Branched Continued Fraction Expansions
Authors: Antonova Tamara , Dmytryshyn Roman , Sharyn Serhii
Published: November 2021

The paper is related to the classical problem of the rational approximation of analytic functions of one or several variables, particulary the issues that arise in the construction and studying of continued fraction expansions and their multidimensional generalizations—branched continued fraction expansions. We used combinations of three- and four-term recurrence relations of the generalized hypergeometric function 3F2 to construct the branched continued fraction expansions of the ratios of this function. We also used the concept of correspondence and the research method to extend convergence, already known for a small region, to a larger region. As a result, we have established some convergence criteria for the expansions mentioned above. It is proved that the branched continued fraction expansions converges to the functions that are an analytic continuation of the ratios mentioned above in some region. The constructed expansions can approximate the solutions of certain differential equations and analytic functions, which are represented by generalized hypergeometric function 3F2. To illustrate this, we have given a few numerical experiments at the end.
Immune Modulatory Effects of Probiotic Streptococcus thermophilus on Human Monocytes
Authors: Dargahi Narges , Johnson Joshua C. , Apostolopoulos Vasso
Published: November 2021

Ingesting probiotics contributes to the development of a healthy microflora in the GIT with established benefits to human health. Some of these beneficial effects may be through the modulation of the immune system. In addition, probiotics have become more common in the treatment of many inflammatory and immune disorders. Here, we demonstrate a range of immune modulating effects of Streptococcus thermophilus by human monocytes, including decreased mRNA expression of IL-1R, IL-18, IFNαR1, IFNγR1, CCL2, CCR5, TLR-1, TLR-2, TLR-4, TLR-5, TLR-6, TLR-8, CD14, CD86, CD4, ITGAM, LYZ, TYK2, IFNR1, IRAK-1, NOD2, MYD88, SLC11A1, and increased expression of IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-23, IFNγ, TNFα, CSF-2. The routine administration of Streptococcus thermophilus in fermented dairy products and their consumption may be beneficial to the treatment/management of inflammatory and autoimmune diseases.
Bright Light Therapy for Parkinson Disease: A Literature Review and Meta-Analysis of Randomized Controlled Trials
Authors: Huang Hsu-Tung , Huang Tsai-Wei , Hong Chien-Tai
Published: November 2021

Sleep disorders and depression are significant nonmotor symptoms (NMSs) of Parkinson disease (PD). However, few effective, evidence-proven medical treatments are available for alleviating these symptoms. Bright light therapy (BLT) is a well-established treatment for circadian rhythm sleep disorders and seasonal affective disorder. The present study conducted a literature review for the effect of BLT on PD, especially a meta-analysis of randomized controlled trials (RCTs). We searched for studies using the PubMed and Cochrane Library databases. The major outcomes were the effects on sleep and depression. The effect on motor symptoms was also analyzed as a secondary outcome. This study was registered with PROSPERO (CRD42020204454). Six studies were included in the literature review only, and the other five RCTs were included in the meta-analysis. Despite the positive effects of BLT on PD patients, which were demonstrated in noncontrolled studies, in the meta-analysis of the RCTs, BLT did not significantly improve the depressive symptoms (standardized mean difference (SMD): −0.15, 95% confidence interval (CI): −0.48 to 0.17, p = 0.36) and excessive daytime sleepiness (EDS) (SMD: −0.12, 95% CI: −0.49 to 0.25, p = 0.53) in PD patients. Regarding motor symptoms, no significant beneficial effects were conferred (SMD: −0.11, 95% CI: −0.44 to 0.21, p = 0.49). In conclusion, BLT did not significantly alleviate depression and sleepiness. The inconsistency between BLT protocols, such as the varied timing, dosages, and treatment durations, may render BLT’s efficacy difficult to demonstrate. The small effect size obtained from the present meta-analysis indicates that future RCTs are necessary, for which BLT protocols are standardized and more patients are enrolled to determine whether a significant therapeutic benefit was conferred.
Immune Checkpoint Inhibitor Therapy Induces Inflammatory Activity in the Large Arteries of Lymphoma Patients under 50 Years of Age
Authors: Calabretta Raffaella , Staber Philipp B. , Kornauth Christoph , Lu Xia , Binder Patrick , Pichler Verena , Mitterhauser Markus , Haug Alexander , Li Xiang , Hacker Marcus
Published: November 2021

Background: Immune checkpoint inhibitors (ICI) have transformed the management of various cancers. Serious and potentially fatal cardiovascular toxicity, as well as a progression of atherosclerosis, have been described, mainly in elderly and comorbid patients. Methods: We investigated 117 arterial segments of 12 young (under 50 years of age), otherwise healthy lymphoma patients pre/post-ICI treatment using 2-[18F]fluorodeoxyglucose (FDG) positron emission tomography (PET). Maximum FDG standardized uptake values (SUVmax) and target-to-background ratios (TBRs) were calculated along arterial segments. Additionally, metabolic activities (SUVmax) of the bone marrow, spleen, and liver were analyzed. The levels of high-sensitivity C-reactive protein (hsCRP) were assessed. Results: ICI therapy induced arterial inflammatory activity, detected by increased TBR in arterial segments without pre-existing inflammation (TBRneg_pre = 1.20 ± 0.22 vs. TBRneg_post = 1.71 ± 0.45, p < 0.001), whereas already-inflamed lesions remained unchanged. Dormant calcified segments (Hounsfield Units-HU ≥ 130) showed a significant increase in TBR values after ICI treatment (TBRcalc_pre = 1.36 ± 0.38 vs. TBRcalc_post = 1.76 ± 0.42, p < 0.001). FDG uptake measured in other organs and hsCRP levels remained unchanged after ICI therapy. Conclusions: Although the effects of ICI therapy on arterial inflammation are still incompletely understood, cancer immunotherapy might be a critical moderator of atherosclerosis with a subsequently increased risk of future cerebro- and/or cardiovascular events in young oncological patients.
Comparative Genomic Characterization of Buffalo Fibronectin Type III Domain Proteins: Exploring the Novel Role of FNDC5/Irisin as a Ligand of Gonadal Receptors
Authors: Wu Siwen , Hassan Faiz-ul , Luo Yuhong , Fatima Israr , Ahmed Ishtiaq , Ihsan Awais , Safdar Warda , Liu Qingyou , Rehman Saif ur
Published: November 2021

FN-III proteins are widely distributed in mammals and are usually involved in cellular growth, differentiation, and adhesion. The FNDC5/irisin regulates energy metabolism and is present in different tissues (liver, brain, etc.). The present study aimed to investigate the physiochemical characteristics and the evolution of FN-III proteins and FNDC5/irisin as a ligand targeting the gonadal receptors including androgen (AR), DDB1 and CUL4 associated factor 6 (DCAF6), estrogen-related receptor β (ERR-β), estrogen-related receptor γ (ERR-γ), Krüppel-like factor 15 (KLF15), and nuclear receptor subfamily 3 group C member 1 (NR3C1). Moreover, the putative role of irisin in folliculogenesis and spermatogenesis was also elucidated. We presented the molecular structure and function of 29 FN-III genes widely distributed in the buffalo genome. Phylogenetic analysis, motif, and conserved domain pattern demonstrated the evolutionary well-conserved nature of FN-III proteins with a variety of stable to unstable, hydrophobic to hydrophilic, and thermostable to thermo-unstable properties. The comparative structural configuration of FNDC5 revealed amino acid variations but still the FNDC5 structure of humans, buffalo, and cattle was quite similar to each other. For the first time, we predicted the binding scores and interface residues of FNDC5/irisin as a ligand for six representative receptors having a functional role in energy homeostasis, and a significant involvement in folliculogenesis and spermatogenesis in buffalo.
Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology
Authors: Sewgobind Nishant V. , Albers Sanne , Pieters Roland J.
Published: November 2021

Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-galactosides. It has been described to be involved in apoptosis, proliferation and differentiation, but also in cell adhesion and migration. Several disorders and diseases are discussed by covering the aforementioned biological processes. Structural features of galectin-7 are discussed as well as targeting the protein intracellularly or extracellularly. The exact molecular mechanisms that lie behind many biological processes involving galectin-7 are not known. It is therefore useful to come up with chemical probes or tools in order to obtain knowledge of the physiological processes. The objective of this review is to summarize the roles and functions of galectin-7 in the human body, providing reasons why it is necessary to design inhibitors for galectin-7, to give the reader structural insights and describe its current inhibitors.
Novel Methylation Biomarkers for Colorectal Cancer Prognosis
Authors: Gutierrez Alvaro , Demond Hannah , Brebi Priscilla , Ili Carmen Gloria
Published: November 2021

Colorectal cancer (CRC) comprises the third most common cancer worldwide and the second regarding number of deaths. In order to make a correct and early diagnosis to predict metastasis formation, biomarkers are an important tool. Although there are multiple signaling pathways associated with cancer progression, the most recognized are the MAPK pathway, p53 pathway, and TGF-β pathway. These pathways regulate many important functions in the cell, such as cell cycle regulation, proliferation, differentiation, and metastasis formation, among others. Changes in expression in genes belonging to these pathways are drivers of carcinogenesis. Often these expression changes are caused by mutations; however, epigenetic changes, such as DNA methylation, are increasingly acknowledged to play a role in the deregulation of oncogenic genes. This makes DNA methylation changes an interesting biomarkers in cancer. Among the newly identified biomarkers for CRC metastasis INHBB, SMOC2, BDNF, and TBRG4 are included, all of which are highly deregulated by methylation and closely associated with metastasis. The identification of such biomarkers in metastasis of CRC may allow a better treatment and early identification of cancer formation in order to perform better diagnostics and improve the life expectancy.
Dynamic DNA Methylation Changes in the COMT Gene Promoter Region in Response to Mental Stress and Its Modulation by Transcranial Direct Current Stimulation
Authors: Wiegand Ariane , Blickle Arne , Brückmann Christof , Weller Simone , Nieratschker Vanessa , Plewnia Christian
Published: November 2021

Changes in epigenetic modifications present a mechanism how environmental factors, such as the experience of stress, can alter gene regulation. While stress-related disorders have consistently been associated with differential DNA methylation, little is known about the time scale in which these alterations emerge. We investigated dynamic DNA methylation changes in whole blood of 42 healthy male individuals in response to a stressful cognitive task, its association with concentration changes in cortisol, and its modulation by transcranial direct current stimulation (tDCS). We observed a continuous increase in COMT promotor DNA methylation which correlated with higher saliva cortisol levels and was still detectable one week later. However, this lasting effect was suppressed by concurrent activity-enhancing anodal tDCS to the dorsolateral prefrontal cortex. Our findings support the significance of gene-specific DNA methylation in whole blood as potential biomarkers for stress-related effects. Moreover, they suggest alternative molecular mechanisms possibly involved in lasting behavioral effects of tDCS.
Genomic and Phylogenetic Analysis of Lactiplantibacillus plantarum L125, and Evaluation of Its Anti-Proliferative and Cytotoxic Activity in Cancer Cells
Authors: Tegopoulos Konstantinos , Stergiou Odysseas Sotirios , Kiousi Despoina Eugenia , Tsifintaris Margaritis , Koletsou Ellie , Papageorgiou Aristotelis C. , Argyri Anthoula A. , Chorianopoulos Nikos , Galanis Alex , Kolovos Petros
Published: November 2021

Lactiplantibacillus plantarum is a diverse species that includes nomadic strains isolated from a variety of environmental niches. Several L. plantarum strains are being incorporated in fermented foodstuffs as starter cultures, while some of them have also been characterized as probiotics. In this study, we present the draft genome sequence of L. plantarum L125, a potential probiotic strain presenting biotechnological interest, originally isolated from a traditional fermented meat product. Phylogenetic and comparative genomic analysis with other potential probiotic L. plantarum strains were performed to determine its evolutionary relationships. Furthermore, we located genes involved in the probiotic phenotype by whole genome annotation. Indeed, genes coding for proteins mediating host–microbe interactions and bile salt, heat and cold stress tolerance were identified. Concerning the potential health-promoting attributes of the novel strain, we determined that L. plantarum L125 carries an incomplete plantaricin gene cluster, in agreement with previous in vitro findings, where no bacteriocin-like activity was detected. Moreover, we showed that cell-free culture supernatant (CFCS) of L. plantarum L125 exerts anti-proliferative, anti-clonogenic and anti-migration activity against the human colon adenocarcinoma cell line, HT-29. Conclusively, L. plantarum L125 presents desirable probiotic traits. Future studies will elucidate further its biological and health-related properties.
Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Authors: Simonato Manuela , Dall’Acqua Stefano , Zilli Caterina , Sut Stefania , Tenconi Romano , Gallo Nicoletta , Sfriso Paolo , Sartori Leonardo , Cavallin Francesco , Fiocco Ugo , Cogo Paola , Agostinis Paolo , Aldovini Anna , Bruttomesso Daniela , Marcolongo Renzo , Comai Stefano , Baritussio Aldo
Published: November 2021

Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits. Therefore, serious attempts are underway to partition them into subgroups useful for a personalized medicine approach to the disease. Here, we investigated clinical and biochemical traits in 40 ME/CFS patients and 40 sex- and age-matched healthy controls. Particularly, we analyzed serum levels of some cytokines, Fatty Acid Binding Protein 2 (FAPB-2), tryptophan, and some of its metabolites via serotonin and kynurenine. ME/CFS patients were heterogeneous for genetic background, trigger, start mode, symptoms, and evolution. ME/CFS patients had higher levels of IL-17A (p = 0.018), FABP-2 (p = 0.002), and 3-hydroxykynurenine (p = 0.037) and lower levels of kynurenine (p = 0.012) and serotonin (p = 0.045) than controls. Changes in kynurenine and 3-hydroxykynurenine were associated with increased kynurenic acid/kynurenine and 3-hydroxykynurenine/kynurenine ratios, indirect measures of kynurenine aminotransferases and kynurenine 3-monooxygenase enzymatic activities, respectively. No correlation was found among cytokines, FABP-2, and tryptophan metabolites, suggesting that inflammation, anomalies of the intestinal barrier, and changes of tryptophan metabolism may be independently associated with the pathogenesis of the disease. Interestingly, patients with the start of the disease after infection showed lower levels of kynurenine (p = 0.034) than those not starting after an infection. Changes in tryptophan metabolites and increased IL-17A levels in ME/CFS could both be compatible with anomalies in the sphere of energy metabolism. Overall, clinical traits together with serum biomarkers related to inflammation, intestine function, and tryptophan metabolism deserve to be further considered for the development of personalized medicine strategies for ME/CFS.