bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards a theory regarding open innovation and entrepreneurship: a meta-synthesis from qualitative studies in small and medium enterprises and start-ups
Authors: Carvalho Eduardo Gomes , Sugano Joel Yutaka
Published: July 2017

Open innovation is still after a decade an emergent topic in literature and, because of this, there are few gaps to be explored. Two of these gaps are the relationship between open innovation and entrepreneurship and open innovation in small and medium enterprises (SMEs), because most studies focus on large enterprises. Our research question in this study is: what do case studies report in terms of open innovation in start-ups or SMEs that would be related to entrepreneurial orientation? Our study is a meta-synthesis of qualitative case studies following the stages presented by Hoon (2013). A theory was developed and presented considering the entrepreneurial orientation dimensions and open innovation activities. In the concluding section, limitations and suggestions in terms of future works were presented.
Confiança do empregado na organização e comprometimento organizacional: em busca da relação entre os construtos
Authors: Cunha Daniele Estivalete , Silva Andressa Hennig , Estivalete Vania De Fátima Barros , De Andrade Neves Hörbe Tatiane , Moura Gilnei Luiz de
Published: July 2017

This study was developed based on the identification of an association of confidence of the employees into the enterprise with organizational commitment. Thus, a descriptive research took place, with a quantitative approach, surveying 76 collaborators from the company Beta, which works in the field of monitoring and security. The instruments used to collect data were the ECEO (Scale of Confidence of the Employee in the Enterprise) and the EBACO (Scale of Basis of Organizational Commitment). For the analysis of data, it was used: descriptive statistics, factorial analysis, and Pearson’s correlation coefficient, in order to establish a relationship between the constructs. The study points that the original factorial structure of the two instruments was not confirmed in this research. As main results, it was evident that trust is much more represented by the ethical standards and organizational solidity, while commitment is configured as an affiliation between the members of the organization. It was also indicated that there is an association between the factors. And as limitations of the study, based on the size of the sample, the authors can infer that the results cannot be generalized.
A estratégia da qualidade ou a qualidade da estratégia? Uma avaliação da adoção da gestão estratégica na norma ABNT NBR ISO 9001:2015
Authors: Pereira do Nascimento Adelson , Pascuci Lucilaine Maria , Nascimento Luiz Carlos , Valadares de Oliveira Marcos Paulo
Published: July 2017

Although the literature points out that quality management is closely linked to the strategic management of an organization, it is surprising that the pre-2015 versions of ISO 9001 - reference standard for the implementation of Quality Management Systems (QMS) - did not have mandatory requirements for linking quality management to organizational strategy. This study examines the new revision of the standard, published in September 2015, which incorporates new strategic management requirements aimed at reorienting organizations and their QMS into their business operations. In a first phase, a detailed verification of the changes of the standard proposed by the International Organization for Standardization (ISO), which expects a closer approximation of quality management to strategic management, was carried out. The work also sought to evaluate the implications of this review through the analysis of reviewers of the standard, consultants and auditors of certified companies. The analysis shows that the insertion of strategic management into ISO 9001 can leverage the degree of participation of top management in the effectiveness of QMS of certified companies, systematize strategic management as a routine in these companies and contribute with managers, auditors and consultants, in order to minimize potential impacts on the adequacy of its QMS.
Aderência entre gestão de projetos e o sistema de gestão de convênios e contratos de repasse (SICONV)
Authors: Moutinho José Da Assunção , Rabechini Junior Roque
Published: July 2017

Highlights

- Analysis of the management model of the System of Management of Agreements and Transfer Contracts (SICONV).

- Relationship established between the phases of an agreement, managed through the SICONV, and the process groups defined by the Project Management Institute (PMI).

- The management model adopted has different intensities of adherence to project management practices, depending on the area of knowledge analyzed and the phase of the SICONV life cycle.

Objective

Study the adherence between the PMI and SICONV project management practices. Even with PMI's efforts in designing the Project Management Body of Knowledge (PMBOK) specifically for the Government sector, there is no study linking it to the electronic environment that supports voluntary transfers (SICONV).

Approach

The article discusses project concepts and project management; contextualizes the management of projects in the public environment and the organization of the Brazilian State, with emphasis on the role of municipalities in the transfer of voluntary resources; presents the SICONV, its phases and functionalities and draws a parallel between the PMI process groups and the SICONV operational flow.

Findings

The model defined by the SICONV environment clearly emphasizes the formal and legal aspects of voluntary transfers of resources, that is, the proposal of the project by the municipal entity, the conclusion of the agreement between the municipality and the Brazilian federal government, the formalization of the act, the monitoring of the implementation of the project and the rendering of accounts. It is also worth noting that the management model adopted has different intensities of adherence to the practices in project management, depending on the area of knowledge analyzed and the phase of the life cycle of the environment.

Research limitations

The adherence analysis of project management practices to SICONV indicates gaps that pave the way for further research, given the dynamics of the presented environment.

Practical implications

The research presents the adherence between areas of knowledge in project management and SICONV environment, pointing to the need to expand the model with the objective of increasing the management of voluntary transfers to higher levels.

Originality/Value

There is a strong restriction in the literature on the wide adoption of project management practices in public administration due to the peculiarities of the environment. Thus, understanding the existing adherence between project management practices and SICONV for Brazilian municipalities can help to fill this gap.
Modelo de otimização de recursos financeiros para o gerenciamento de riscos empresariais
Authors: Paulo Wanderlei Lima , Fernandes Francisco Carlos , Silva Marcia Zanievicz
Published: July 2017

This article aims to propose a model to determine the best allocation of financial resources for business risk management, permitting the risk manager to define a control policy with reduced costs that reaches a desired control target. The problem of study is presented as an issue of optimization of costs, formulated as a model of whole linear programming, which basic restrictions are associated to the demanded levels of control. The proposed model is applied to a problem of resource allocation for the control of operational costs. The results show that the model is an adequate instrument to better allocate financial resources, which its use proportionates better conditions for the decision process of business risks.
Auditorias ambientais compulsórias: estudo de uma indústria química
Authors: Monteiro Paulo , Pessoa Lucas , Fontoura Geraldo
Published: July 2017

This article was developed with the objective of analyzing the use of compulsory environmental audits as a tool to evaluate the environmental performance of a chemical industry. The research method used consisted of the analysis of reports of environmental audits carried out from 2011 to 2014, in the light of Directive 056 - Rev3. It can be concluded that the audit helped the company, improving its environmental performance, since there was a reduction in the number of nonconformities, a decrease in energy and water expenditure and optimization of the processes through the improvement opportunities detected.
Avaliação de curvas de crescimento em suínos
Authors: Nascimento C.A.M.S. , Ribeiro N.M. , Rocha L.L. , Lucena L.R.R.
Published: July 2017

Objetivou-se simular pesos de suínos machos e fêmeas (de 1 a 157 dias de idade) através da distribuição de probabilidade uniforme num intervalo [a,b]. Foram ajustados os modelos de regressão (logístico, potência, tangente hiperbólica, gamma e polinomial cúbico) para explicar a possível relação do peso com o número de dias dos suínos. Verificou-se que os modelos logístico, gamma e polinomial cúbico apresentaram as melhores estimativas para explicar o comportamento do peso dos suínos machos e fêmeas. O modelo logístico apresentou R²= 0,975 e AIC=13,34 para os machos e R²= 0,9787 e AIC= 10,16 para as fêmeas. O modelo gamma apresentou grau de explicação de R²= 0,991 e AIC= 99,33 para os machos e R²= 0,9941 e AIC= 90,602 para as fêmeas, enquanto que o modelo polinomial cúbico apresentou R= 0,9995 e AIC=64,2 para os machos e R²= 0,9995 e AIC= 31,728 para as fêmeas. Optou-se pelo modelo polinomial cúbico para explicar o comportamento do peso simulado dos suínos, pois o mesmo apresentou R² alto e baixo AIC além de menos parâmetros que os outros modelos.
Efecto de la suplementación del diluyente sobre la calidad del semen de asno a la descongelación
Authors: Montoya J.D. , Rojano B. , Restrepo G.
Published: July 2017

La congelación de semen de asno permite almacenar material genético por un periodo ilimitado de tiempo, por lo que puede ser empleado para generar bancos de germoplasma o para la cría de mulares y asnos. Esta investigación tuvo como objetivo evaluar alternativas de suplementación de un diluyente para la congelación de semen de asno. Se colectó el semen de cinco asnos criollos colombianos, dos eyaculados por animal (n= 10) y luego se congeló en diluyente Equiplus® suplementado con 3% de glicerol (GLY) ó 5% de dimetilformamida (DMF), 2% ó 5% de yema de huevo centrifugada (YHC) y 10% ó 20% de plasma seminal (PS). Se realizó la evaluación post-descongelación de la calidad seminal y de la peroxidación lipídica (PL). Para el análisis estadístico se ajustaron modelos mixtos, se realizó un análisis de regresión y comparaciones de medias por la prueba de Tukey. El semen congelado con 5% de DMF, 5% de YHC y 10% de PS presentó valores superiores de movilidad, vitalidad e integridad de membrana (p<0,05). La PL fue menor en diluyentes con 5% de YHC (p < 0,05). La suplementación del diluyente de congelación con una combinación de 5% de DMF, 5% de YHC y 10% de PS permite mejorar la calidad post-descongelación del semen de asno.
Evaluación de diferentes niveles de inclusión de plantas nativas de sabanas inundables sobre una dieta basal de Brachiaria humidicola y su efecto sobre la producción de metano in vitro
Authors: Vélez O.M. , Campos R. , Sánchez H. , Giraldo L.A.
Published: July 2017

Se evaluó el efecto sobre la producción de metano de la inclusión creciente (25, 50 y 75 %) de cinco plantas nativas de sabanas inundables (Senna occidentalis, Enterolobium schomburgkii, Galactia jussiaeana, Belencita nemorosa y Ambrosia peruviana), sobre una dieta base de Brachiaria humidicola. Los tratamientos fueron incubados anaeróbicamente con fluido ruminal a 39°C por 24 h y después del proceso de fermentación, se determinó la producción de gas, metano, ácidos grasos volátiles (AGV), amonio y degradación de la materia seca (MSD). La inclusión en la dieta de 50 y 75% de todas las plantas, incrementaron el contenido de amonio ruminal, con valores entre 189 - 282 mg/L. Ninguna de las plantas modificó la concentración de AGVT (44-62 mmol/L). La producción de metano no se redujo significativamente con ningún tratamiento (p>0,05), aunque con S. occidentalis (75%) este parámetro fue inferior en un 18%, además, se incrementó la MSD y los niveles de butirato, isobutirato y valerato. Con E. schomburgkii (75%), la metanogénesis también se redujo en un 15%, sin embargo, este efecto estuvo acompañado de una disminución en la MSD y producción de gas. En conclusión, ninguna de las plantas mostró potencial para reducir la producción de metano, no obstante, las especies se convierten en alternativas nutricionales útiles para complementar el aporte proteico de la dieta en los sistemas ganaderos ubicados en condiciones de sabanas inundables.
Substituição total do milho pela polpa cítrica no concentrado de bezerros leiteiros
Authors: Coimbra E.P. , Azevedo R.A. , Reis R.B. , Saturnino H.M. , Coelho S.G.
Published: July 2017

Objetivou-se avaliar os efeitos da substituição do milho pela polpa cítrica no concentrado sobre o desempenho e os parâmetros ruminais de bezerros até 60 dias de idade. Foram utilizados bezerros Holandês (n= 36), sendo 28 para as análises de consumo e desempenho e 8 para estudo dos parâmetros da fermentação ruminal e perfil da glicose sanguínea. Ao final, 4 animais de cada tratamento foram eutanasiados para análises do epitélio ruminal. O consumo de concentrado diferiu entre os tratamentos da 5ª à 9ª semana de idade, sendo maior para o grupo alimentado com concentrado com milho. O ganho de peso e a concentração sanguínea de glicose foram semelhantes entre os tratamentos. A concentração molar de acetato, propionato, butírico, total de AGV e os valores de pH ruminal não diferiram entre os grupos. O maior percentual de propionato e o butirato foram observados respectivamente para os bezerros com dieta à base de milho e à base de polpa cítrica. Pequenas alterações anato-patológicas foram encontradas no epitélio ruminal dos bezerros alimentados com polpa cítrica no concentrado. Os resultados sugerem que a polpa cítrica é um coproduto com potencial de ser utilizada em substituição ao milho no concentrado de bezerros até 60 dias de idade.
Características produtivas e estruturais de genótipos de palma forrageira irrigada em diferentes intervalos de corte
Authors: Rocha R.S. , Voltolini T.V. , Gava C.A.T.
Published: July 2017

A palma forrageira, recebendo aporte adicional de água, pode se constituir em alternativa alimentar para os rebanhos da região semiárida brasileira, entretanto são escassas as informações sobre as respostas produtivas e estruturais dos genótipos, assim como do intervalo de cortes da planta. Esta pesquisa teve o objetivo de avaliar as características produtivas e estruturais de genótipos de palma forrageira em diferentes intervalos de corte. O delineamento experimental foi em blocos completos casualizados com parcelas subdivididas tendo os genótipos dispostos nas parcelas e os intervalos de corte nas subparcelas, com quatro repetições por tratamento, totalizando 48 unidades experimentais. O experimento foi realizado no período de maio de 2014 a setembro de 2015, com três genótipos de palma forrageira, a Orelha de Elefante Mexicana (OEM) (Opuntia stricta (Haw.) Haw.), IPA 20 (Opuntia ficus indica (Mill)) e a Miuda (Nopalea cochenillifera Salm. Dyck) e intervalos de corte de 4, 8, 12 e 16 meses após o plantio. A OEM aos 16 meses apresentou maior massa de forragem (t de matéria seca/ha e matéria verde/ha) em comparação com a Miuda e IPA 20 nos diferentes intervalos de corte, tendo ainda maior taxa de acúmulo de forragem e melhor eficiência de uso da água. A Miuda teve maior número de cladódios e cladódios mais leves. A OEM juntamente com a Miuda apresentaram maiores índices de área de cladódio a partir de oito meses após o plantio comparada à IPA 20. Os genótipos assim como o intervalo de corte afetam as características produtivas e estruturais da palma forrageira.
Complexo enzimático na alimentação artificial de abelhas africanizadas
Authors: Lima M.V. , Soares K.O. , Evangelista-Rodrigues A.
Published: July 2017

Este estudo objetivou identificar uma alimentação eficiente para as abelhas Apis mellifera L. utilizando um complexo enzimático para melhorar o desempenho dos enxames em períodos de escassez alimentar. Para isso, quadros de cria fechada foram retirados de duas colmeias, conduzidos até uma câmera climatizada e após a emergência, as abelhas foram mantidas em unidades experimentais para serem alimentadas. A dieta utilizada na pesquisa foi composta por 60% de mel, 30% de farinha de soja e 10% de farinha de milho, com diferentes níveis de inclusão (0,00%, 0,03%, 0,06%, 0,09%) do complexo enzimático em estudo. Os parâmetros avaliados foram: longevidade das abelhas, concentração de proteína total da hemolinfa e consumo de água e dieta. Não houve efeito toxicológico de acordo com análise de sobrevivência, verificou-se uma redução no consumo, conforme foi acrescentado o complexo enzimático na dieta e um aumento no teor de proteína na hemolinfa. O uso do complexo enzimático mostrou-se como uma ferramenta para manter os enxames em períodos de escassez de alimento, pois proporcionou melhor aproveitamento dos alimentos por menor consumo da dieta e o maior teor de proteína total na hemolinfa.
Níveis de glicerina bruta na ração de suínos nas fases de crescimento e terminação
Authors: Bordignon G. , Lima H.J.D. , Martins R.A. , Fonseca M.M.
Published: July 2017

O objetivo do presente trabalho, foi avaliar o efeito da inclusão de diferentes níveis de glicerina bruta nas rações, sobre o desempenho de suínos em crescimento e terminação. Foram utilizados 60 suínos F1 (30 machos e 30 fêmeas), oriundos do cruzamento entre fêmeas Naïma e machos da linhagem comercial P76, com peso inicial de 18,46 ± 1,38 kg, distribuídos em delineamento inteiramente casualizado, com 4 tratamentos e 5 repetições, sendo 3 animais por unidade experimental. As rações foram formuladas à base de milho e farelo de soja, com a inclusão de 0, 5, 10 e 15% de glicerina bruta. As características de desempenho avaliadas foram: ganho de peso, consumo de ração e conversão alimentar. Não foi observada influência (p>0,05) da inclusão de glicerina bruta nas rações sobre as características de desempenho avaliadas nas fases de crescimento e terminação. Recomenda-se a inclusão de até 15% de glicerina bruta nas rações de suínos em crescimento e terminação, sem efeitos prejudiciais ao desempenho produtivo.
Relación de la dieta con el color y la terneza de la carne vacuna
Authors: Della Rosa M.M. , Papaleo Mazzucco J. , Aello M.S.
Published: July 2017

Para el consumidor de carne vacuna la calidad sensorial es importante al momento de la compra y el consumo. El color depende mayormente de la concentración de mioglobina y el pH, en tanto que la terneza está relacionada con el pH, la composición del colágeno y la degradación miofibrilar. Todos ellos pueden influenciarse por la dieta. La concentración de mioglobina depende del tipo de fibra muscular, cuyo metabolismo está influenciado por la dieta que reciban los animales. Las dietas de baja energía se asocian a fibras rojas, con metabolismo oxidativo y mayor concentración de mioglobina, mientras que las dietas ricas en energía estimulan el desarrollo de fibras glucolíticas. Estas últimas, tienen la capacidad de acumular más glucógeno. El metabolismo de las miofibras también afecta al contenido de enzimas proteolíticas, las fibras oxidativas presentan mayor concentración de calpaínas que las fibras glicolíticas. La estructura del colágeno es influenciada por la dieta de forma indirecta, ya que su efecto está mediado por la tasa de ganancia de peso. Al consumir dietas energéticas los animales incrementan la velocidad de ganancia de peso, lo que disminuye el colágeno total por un efecto de dilución debido al aumento de miofibrillas. Por otro lado, la energía puede retrasar la formación y estabilización de las estructuras del colágeno, con aumento de la fracción soluble. La dieta cumple un rol importante sobre la calidad de la carne, por lo tanto mantener un buen nivel de alimentación permite maximizar la calidad y lograr un producto con atributos sensoriales coincidentes con los requeridos por un gran número de consumidores.
Comparative Study between Parallel K-Means and Parallel K-Medoids with Message Passing Interface (MPI)
Authors: Nhita Fhira
Published: July 2017

Data mining is a combination technology for analyze a useful information from dataset using some technique such as classification, clustering, and etc. Clustering is one of the most used data mining technique these day. K-Means and K-Medoids is one of clustering algorithms that mostly used because it’s easy implementation, efficient, and also present good results. Besides mining important information, the needs of time spent when mining data is also a concern in today era considering the real world applications produce huge volume of data. This research analyzed the result from K-Means and K-Medoids algorithm and time performance using High Performance Computing (HPC) Cluster to parallelize K-Means and K-Medoids algorithms and using Message Passing Interface (MPI) library. The results shown that K-Means algorithm gives smaller SSE than K-Medoids. And also parallel algorithm that used MPI gives faster computation time than sequential algorithm.
GROUP OF AUTHORS UNDER THE SUPERVISION OF ACADEMICIAN VG SAVCHENKO
Authors: Turkina A.G. , Zaritskii A.Yu. , Shuvaev V.A. , Chelysheva E.Yu. , Lomaia E.G. , Morozova E.V. , Golenkov A.K. , Pospelova T.I. , Shukhov O.A. , Fominykh M.S. , Gusarova G.A. , Kuz'mina L.A. , Abdullaev A.O. , Martynkevich I.S.
Published: July 2017

This article is the 4th edition of the recommendations for the diagnosis and treatment of chronic myeloid leukemia. The group of authors reviewed and discussed relevant new publications, and included the significant remarks and comments of experts. Particular attention was paid to the control of risk factors for the development of arterial vascular events and their prevention, and adverse effects of the longterm therapy with tyrosine kinase inhibitors, which were being increasingly reported in recent years.
Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy
Authors: Pokrovskii V.S. , Davydov D.Zh. , Davydov N.V. , Zhdanov D.D. , Revtovich S.V. , Morozova E.A. , Demidkina T.V. , Treshchalina E.M.
Published: July 2017

This review presents the characteristics of the cellular metabolism of methionine, as well as known data on the mechanisms of the development of methionine dependence in malignant cells. The possibilities of using a non-methionine diet for the control of the tumor growth in patients with various forms of cancer are considered. The information about methionine Y-lyase, an enzyme providing elimination of methionine from plasma, is provided. Its role as a potential antitumor enzyme is disclosed. Data on cytotoxic activity of the enzyme, obtained from various sources, and information on tumor models and cell cultures, showing methionine dependence are summarised.
The IVDG Regimen is the Possible Treatment of Choice as First Line Therapy For Hodgkin’s Lymphoma in Elderly Patients with Cardiovascular and Pulmonary Comorbidity
Authors: Kaplanov' K.D. , Klitochenko T.Yu. , Shipaeva A.L. , Shirokova M.N. , Matveeva I.V. , Lavrishina N.B.
Published: July 2017

Background. Among the newly diagnosed patients with Hodgkin's lymphoma (HL), the proportion of elderly patients account for 15-35 %. In > 60 age group the choice of antitumor treatment requires an more individualised approach compared to a younger population. The ABVD regimen is acceptable in terms of efficiency and hematological toxicity, but is associated with a high risk of bleomycine-induced pulmonary complications. In > 60 age group the morbitity and mortality of pulmonary complications account for 24 % and 18 %, respectively. Aim. We aimed to evaluate the efficacy of the IVDG regimen in comparison with ABVD by the principle of “non-inferiority”. Materials & Methods. This single centre, prospective, controlled, randomised study was started in 2009. The study included all primary patients aged > 60 years with verified HL, regardless of the number and severity of comorbidities. The ABVD regimen was administered in 17 patients, and 20 patients received IVDG. The median age in the ABVD and IVDG groups was 67 and 70 years, respectively. The advanced stages of HL were reported in 13 (65 %) patients on IVDG, and in 12 (71 %) patients on ABVD (p = 0.9). Both of the groups were comparable in terms of the prevalence of chronic heart failure and chronic obstructive pulmonary disease. The prevalence of ischemic heart disease was higher in the IVDG group (n = 16) compared to ABVD (n = 8) (p = 0.04). Results. IVDG and ABVD groups did not differ in the frequency of complete (14 and 10) and partial (3 and 4) remissions. Differences in 5-year overall survival were insignificant: 49 % in the IVDG group, vs 22 % in ABVD group (p = 0.41). No infectious or hemorrhagic complications were observed in both groups. The incidence of drug-induced pulmonary fibrosis after treatment was significantly lower in the IVDG group (n = 0) vs ABVD group (n = 4; 24 %) (p = 0.004). Conclusion. The IVDG regimen may be used as first line treatment for HL in the elderly patients, especially in those having cardiac or pulmonary comorbidities. Compared to ABVD the IVDG regimen had similar efficacy and more beneficial safety profile in terms of cardiovascular and pulmonary toxicity.
Treatment of Drug-Resistant Mycosis Fungoides and Sezary Syndrome
Authors: Gorenkova L.G. , Penskaya E.A. , Kravchenko S.K. , Kovrigina A.M. , Moiseeva T.N. , Vorob'ev A.I.
Published: July 2017

Background. The most common diseases among cutaneous T-cell lymphomas are mycosis fungoides (MF) and its leukemic variant Sezary Syndrome (SS). These malignant tumors have a progressive character course. To date, no therapy for these diseases has proven effective, especially in the late stages of the disease. Aim. We aimed to assess the effectiveness of treating resistant forms of MF/SS with prolonged gemcitabine regimen after initial treatment failure. Materials & Methods. The study included 14 patients with drug-resistant forms of MF/SS (10 patients with MF, 3 patients with SS, and 1 patient with the transformation of MF into large cell lymphoma). The median age was 62 years (range 34-78 years). The study population included 9 males and 7 females. Gemcitabine was administered at a dosage of 250 mg/m2 as a 6-8 hour IV infusion weekly, in a cycle of 21-28 days. Results. The overall response was 79 % (29 % of patients with complete remission, 50 % of patients with partial remission). In 21 % of patients, the treatment results met the criteria for tumor stabilization. The disease progression was observed in 2 (14 %) patients. This study demonstrates the potential of using prolonged gemcitabine regimen in patients of different age groups with advanced resistant MF/SS who received at least two courses of previous ineffective therapy. In order to evaluate long-term results, further research is needed. Conclusion. The administration of prolonged gemcitabine regimen may be a treatment of choice in resistant forms of MF/SS after initial treatment failure in different age groups including elderly patients.
Bortezomib Combination Therapy of Relapsed and Refractory Acute Lymphoblastic Leukemia in Children
Authors: Batmanova N.A. , Shervashidze M.A. , Popa A.V. , Grivtsova L.Yu. , Serebryakova I.N. , Mentkevich G.L.
Published: July 2017

Background & Aims. Despite significant success in the treatment of acute lymphoblastic leukemia (ALL) in children, relapses and drug resistance to the standard therapy remain the main cause of treatment failure. The addition of bortezomib to the combination therapy of relapsed ALL to change the sensitivity of blast cells may be a perspective approach to cure patients. The aim was to evaluate the efficacy and toxicity of the anti-relapse ALL treatment protocols REZ BFM 95/96 without bortezomib and COG AALL07P1 with bortezomib in relapsed and refractory ALL in children. Materials & Methods. The study included 54 children with a confirmed ALL of various localizations. From 1995 to 2011, ALL REZ BFM 95/96 treatment without bortezomib was administered to 26 patients. From 2011 to 2016, 28 children received COG AALL07P1 combination treatment with bortezomib. Results. The immediate treatment efficacy significantly higher in patients treated with bortezomib (85.7 % vs 57.6 %) after induction chemotherapy with the ALL REZ BFM 95/96. The analysis of the long-term outcomes (disease-free, event-free, overall survival) showed no significant differences between the groups. The event-free survival of patients with isolated bone marrow relapses for a period of 2 years was 20.3 ± 17.5 %. The tolerability of the program was acceptable, complications developing during myelosuppression were not associated with the administration of bortezomib. Conclusion. The intensification of induction chemotherapy according to COG AALL07P1 protocol with the addition of bortezomib allowed to increase the number of complete remissions including MRD negative ones.
Molecular Genetic Markers and Clinical Characteristics of Essential Thrombocythemia
Authors: Zhernyakova A.A. , Martynkevich I.S. , Shuvaev V.A. , Polushkina L.B. , Fominykh M.S. , Udal'eva V.Yu. , Zotova I.I. , Shikhbabaeva D.I. , Zenina M.N. , Potikhonova N.A. , Voloshin S.V. , Bessmel'tsev S.S. , Chechetkin A.V. , Abdulkadyrov K.M
Published: July 2017

Background & Aims. The presence of different molecular genetic markers of clonality (mutations in JAK2, MPL, CALR) or their absence (triple negative status, TN) in essential thrombocythemia (ET) indicates a biological heterogeneity of the disease and can determine its clinical forms. The aim was to evaluate the association of molecular genetic markers with the clinical form and the prognosis of ET. Materials & Methods. We analyzed the data of 240 patients with ET at the age of 20-91 years (median age 58.7 years), who were observed in the Russian Research Institute of Hematology and Transfusiology from 1999 to 2016 (median observation period 37.2 months). Results. The JAK2V617F (JAK2+) mutation was found in 182 (75.9 %) of 240 patients. CALR (CALR+) mutations were found in 30 (12.5 %): type 1 (CALP7+) mutations in 13/30 (43.3 %) and type 2 (CALR2+) in 17/30 (56.7 %). MPL (MPL+) mutations were found in only 2 (0.8 %) of 240 patients. None of the mutations were detected in 26 (10.8 %) of 240 patients (TN status). Significantly higher platelet counts were observed in CALP7+ and CALR2+ subgroups during the primary diagnosis of ET compared with JAK2+ and TN groups. The mean platelet counts were 1252 * 109/L for CALR2+ and 1079 * 109/L for CALP7+ vs 841 * 109/L (p < 0.001; p = 0.06) and 775 * 109/L (p < 0.001; p = 0.04) for JAK2+ and TN, respectively. Thrombosis was diagnosed in 50 (27.4 %) of 182 patients of the JAK2+ subgroup, in 8 (30.7 %) of the 26 patients of the TN subgroup, and in 2 (18.2 %) of 11 patients of the CALP7+ subgroup. No thrombosis was found in the CALR2+ and MPL+ subgroups (p < 0.001). In general, the CALP7+ status was characterized as the most favorable in terms of prognosis (5-year overall survival rate of 100 %), compared to the least favorable TN status (5-year overall survival rate of 85 %). Conclusion. Mutations in the CALR gene were characterized by a more favorable prognosis in comparison with JAK2+and TN, as well as a decrease in the risk and frequency of thrombosis, despite higher platelet counts. TN-status of ET was associated with unfavorable prognosis.
The 4Rs and potassium
Authors: Flis Sally
Published: July 2017

Potassium (K) behavior in the soil is different from nitrogen (N) or phosphorus (P). While some of the same factors influence your 4R decisions, the variability of the soil's ability to supply and store K is quite dynamic. Earn 0.5 CEUs in Nutrient Management by reading this article and taking the quiz at https://www.certifiedcropadviser.org/education/classroom/classes/504
The electrochemical elimination of coliforms from water using BBD/Ti or graphite anodes: a comparative study
Authors: GilPavas Edison , Arbeláez Paula , Medina José David , Dobrosz-Gómez Izabela , Gómez-García Miguel Ángel
Published: July 2017

The elimination of total and fecal coliforms, from raw surface water, was carried out by electrochemical oxidation using either boron doped diamond (BDD/Ti) or graphite (GP) anodes, in a chloride-free medium. The optimal values of the operation parameters, maximizing the coliform elimination percentage, were determined using statistical experimental design. The current density (j: 2–20 mA/cm2), the conductivity (σ: 500–900 μS/cm) and the anode materials (An) were considered as variables to perform the Box-Behnken experimental design together with the response surface methodology analysis for optimization. The statistical analysis indicated that, in the evaluated range, the disinfection efficiency increased with an increase in j and decreased with an increase in σ. The following optimal conditions for the elimination of total and fecal coliforms were found: j: 10 mA/cm2, σ: 500 μS/cm and BDD/Ti used as anode material. The BDD/Ti electrode let to achieve complete coliform elimination after ca. 20 min of reaction while the GP one needed ca. 27 min. In water treated with both BDD/Ti and GP anode, after 7 days, any coliforms growth was observed. As a result of the oxidation process, the total organic carbon and nitrite concentration decreased while nitrate concentration increased.
Чоловічий гіпогонадизм (Частина 1)
Authors: Luchytskyy Ye.V. , Luchytskyy V.Yе. , Tronko M.D.
Published: July 2017

У першій частині лекції наведені сучасні дані про поширеність чоловічого гіпогонадизму, методи діагностики різних форм гіпогонадизму; описано клінічну характеристику найбільш поширених форм цієї патології.
Use of Breathing Exercises, Contributing to the Development of General Endurance at Classes of Physical Education
Authors: Kuznetsova L N , Anisimova A Yu , Gibadullin I G
Published: July 2017

Рассматривается методика выполнения дыхательных упражнений, способствующих развитию общей выносливости, на занятиях по физическому воспитанию. Основные методы развития выносливости у студенток: непрерывный, переменный и повторный. При этом на начальных этапах процесса развития выносливости повторный и переменный методы применяются не для того, чтобы повысить интенсивность нагрузки, а в связи с тем, что многие студентки не способны длительное время выполнять двигательные действия даже умеренной интенсивности. По мере роста подготовленности повторный и переменный методы развития выносливости применяются для повышения интенсивности упражнений. Для усиления эффекта воздействия физических упражнений на развитие выносливости на каждом занятии, посвященном решению данной задачи, целесообразно применять комплекс дыхательных упражнений, направленный на повышение эластичности грудной клетки и повышение жизненной емкости легких, на увеличение силы и выносливости дыхательных мышц, а также повышение вентиляционных способностей легких
Modeling of Hob Cutter Using Comparable Gear Rack
Authors: Ryabov E A , Yurasov S Yu , Kondrashov A G
Published: July 2017

Рассмотрена последовательность создания параметрической модели червячной зуборезной фрезы. Параметрическое моделирование имеет ряд особенностей, связанных с постоянным перестроением по изменяемым параметрам. Существуют предельные значения, при которых могут иметь место самопересечения, новые или паразитные грани, которые отсутствуют при проектировании конкретной модели инструмента. Параметрическое моделирование также предполагает создание удобного интерфейса для взаимодействия оператора с моделью. Построение производилось в системе NX, диалоговые окна создавались в приложении «Студия шаблона изделия». Было принято решение поделить проектирование на 3 составляющие. Первое - это полный автоматизированный расчет на основе базовых параметров колеса. Второе - возможность редактирования параметров модели на основе применяемых на конкретном производстве инструментов. Третье - сводная таблица всех получившихся параметров. Представлены в аналитическом виде формулы расчета фланка и протуберанца на фрезах на основе эквивалентного зубчатого колеса. Эквивалентное колесо рассчитывается через отношение инвалюты торцового угла к инвалюте угла исходного контура. Получается эквивалентное прямозубое колесо с новыми параметрами модуля и диаметрами, для которого и ведется классический расчет червячной фрезы. Представлен метод построения, основанный на эквивалентной рейке. Использование эквивалентных элементов для упрощения построений распространено, однако аппроксимация профиля при этом не должна быть больше допуска на построение, который составляет 30…50 % от допуска на измерение. Представлены результаты измерения с помощью трехмерного оптического сканера ATOSIII. Rev.02, который оказался неприменим для точного измерения элементов режущего инструмента ввиду недостаточной стабильности измерения. Главным недостатком измерения трехмерным оптическим сканером оказалась невозможность введения корректировок при дальнейшем изготовлении и переточки получаемой червячной фрезы из-за случайного характера распределения погрешностей измерения.
The implications of company corporate social responsibilities on the development of local communities
Authors: Njapha Zonke , Lekhanya Lawrence Mpele
Published: July 2017

Since Corporate Social Responsibility (CSR) has become established in our vocabulary, over the past few years, business enterprises have come under increasing pressure to accept responsibility for the environment in which they function. This paper is aimed to evaluate the impact of company corporate social responsibilities on the development of local communities. The primary data were collected using the quantitative technique. Data were collected from selected areas of Richards Bay in the Northern region of KwaZulu-Natal (KZN) province. The sample consisted of 129 respondents from the members of communities. The reliability data of this study found to be significant at 0.782. The results reveal that the majority of respondents believe that they do benefit from a local company in many ways. The findings also indicate that the benefits include creation of jobs, capacity building, technology, contracting and business opportunities and social investment. The finding of this study is limited by the study’s exploratory and quantitative nature. Generalizing should be done with care and further research with larger samples and consideration of the other provinces is therefore recommended.
Effects of heavy thinnings on the increment and selection of trees for tending in Norway spruce monoculture in natural hazard conditions
Authors: Bobinac Martin , Andrasev Sinisa , Bauer-Zivkovic Andrijana , Susic Nikola
Published: July 2017

The paper studies the effects of two heavy selection thinnings on the
increment of Norway spruce trees exposed to ice and snow breaks in eastern
Serbia. In a thinning that was carried out at 32 years of age, 556 candidates
per hectare were selected for tending, and at the age of 40, of the initial
candidates, 311 trees per hectare (55.9%) were selected as future trees. In
all trees at 41-50 age period, diameter increment was higher by 31%, basal
area increment by 64% and volume increment by 67% compared to 32-40 age
period. The collective of indifferent trees is significantly falling behind
compared to future trees in terms of increment values in both observed
periods. However, the value of diameter, basal area and volume increments, of
the collective of "comparable" indifferent trees are lower in comparison to
the values of increments of future trees by 10-15% in the 32-40 age period,
and by 15-21% in the 41-50 age period and there are no significant
differences. The results show that heavy selective thinnings, initially
directed at a larger number of candidates for tending at stand age that does
not differ much from the period of carrying out first "commercial" thinnings,
improve the growth potential of future and indifferent trees, where it is
rational to do the tree replacement for the final crop in "susceptible"
growth stage to snow and ice breaks.
Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway
Authors: Mollah Zia U.A. , Quah Hong Sheng , Graham Kate L. , Jhala Gaurang , Krishnamurthy Balasubramanian , Dharma Joanna Francisca M. , Chee Jonathan , Trivedi Prerak M. , Pappas Evan G. , Mackin Leanne , Chu Edward P.F. , Akazawa Satoru , Fynch Stacey , Hodson Charlotte , Deans Andrew J. , Trapani Joseph A. , Chong Mark M.W. , Bird Phillip I. , Brodnicki Thomas C. , Thomas Helen E. , Kay Thomas W.H.
Published: July 2017

Granzyme A is a protease implicated in the degradation of intracellular DNA. Nucleotide complexes are known triggers of systemic autoimmunity, but a role in organ-specific autoimmune disease has not been demonstrated. To investigate whether such a mechanism could be an endogenous trigger for autoimmunity, we examined the impact of granzyme A deficiency in the NOD mouse model of autoimmune diabetes. Granzyme A deficiency resulted in an increased incidence in diabetes associated with accumulation of ssDNA in immune cells and induction of an interferon response in pancreatic islets. Central tolerance to proinsulin in transgenic NOD mice was broken on a granzyme A–deficient background. We have identified a novel endogenous trigger for autoimmune diabetes and an in vivo role for granzyme A in maintaining immune tolerance.
Engaging communities in environmental communication
Authors: Harris Usha Sundar
Published: July 2017

This article makes a case for alternative communication models as a means of strengthening networks both for dialogue and social action in environmental communication. It first charts the emergence of the environmental movement in the Pacific region as a consequence of 50 years of nuclear testing. This is followed by a discussion of contemporary environmental concerns facing Pacific communities and the networks of solidarity that have emerged. Participatory media provides an important platform for local communities through which they can share knowledge, create awareness and provide their own perspectives on environmental issues.
Climate change in Vietnam: Relations between the government and the media in the period 2000-2013
Authors: Pham Binh Duong , Nash Chris
Published: July 2017

Vietnam is fifth in the hierarchy of countries likely to be severely impacted by climate change.  Since 2007 there has been a major expansion of reporting and discussion of this issue in Vietnamese news media.  This article reports on a research study of climate change coverage from 2000 to 2013 in four major news outlets: Vietnam Television (VTV), Tuoi Tre newspaper, Nhan Dan newspaper and VnExpress.  It found considerable variation on the content and temporal spread of coverage, but also some interesting commonalities, in particular an unusually prominent role for NGOs as sources.  There is currently a unity of purpose in the Vietnamese government’s approach to this issue at the moment. In other environmental issues, the major factor affecting government latitude for independent reporting has been the unity or conflict within government on the matter.  Where there has been no conflict there has been considerable latitude for journalists to take initiatives in independent reporting, expand the field of media independence and in the process develop their own capital and professional capacities.  Thus far in climate change reporting journalists have not taken advantage of this opportunity, but if the scientific predictions of catastrophic impacts are valid, the social, economic and political effects will be major, posing strong challenges to Vietnamese journalists.
Coal comfort: Pacific islands on collision course with Australia over emissions
Authors: Morgan Wesley
Published: July 2017

Commentary: During 2017, Fiji is president of negotiations under the United Nation’s Framework Convention on Climate Change (UNFCCC).  It is the first time the talks have been headed by a small island developing country, and Fiji’s Prime Minister Voreqe Bainimarama plans to use the 23rd Conference of Parties to highlight the impacts of climate change on island states.  Even as Pacific island leaders demand greater action to reduce emissions, the Australian government is supporting new coal mines at home and a dramatic increase in coal exports.  This commentary focuses on Pacific leadership in the global fight to avoid catastrophic changes to the climate system.  It suggests determined diplomacy by island states may help shift international opinion in favour of urgent action to reduce emissions. However, Pacific states must first shine a spotlight on their recalcitrant neighbour, and avoid being silenced by Australian ‘climate diplomacy’.
Asian journalism education and key challenges of climate change: A preliminary study
Authors: Maslog Crispin
Published: July 2017

Commentary: The mass media in the Asia Pacific region are reporting the environmental  disasters that are regularly hitting the planet religiously, and journalists learn as they go along. However, the reporting has focused mainly on the toll in human lives and property. This is disaster reporting and it stops short of contextualising. It does not adequately explain why the environmental disasters are happening more violently and more frequently. Not too many reporters have taken formal courses in environmental journalism. Only a very few schools are offering regular courses, or programmes in science and environmental reporting, as indicated by a mini-survey in July 2016. The vacuum in formal science and environmental education is being filled by non-government organisations offering non-formal training.
REVIEW: The revolution still isn’t here
Authors: Cass Philip Leslie
Published: July 2017

Journalism as Activism, by Adrienne Russell. Cambridge: Polity Press, 2016, 200 pages. ISBN 978-0-745-6712-6-0IN 1845 Marx wrote:The class which has the means of material production has control at the same time over the means of mental production so that… generally speaking, the ideas of those who lack the means of mental production are subject to it… as they rule as a class and determine the extent and compass of an epoch, it is self-evident that they…regulate the production and distribution of the ideas of their age; Thus their ideas are the ruling ideas of the epoch.
REVIEW: A thoughtful approach to teaching media
Authors: Cocker Alan
Published: July 2017

Reinventing the Media, by Graeme Turner. London: Routledge. 2015. 158 pages. ISBN 978-1-138-02070-2AS A member of a School of Communication Studies seeking to refresh its curricula, the publication of Graeme Turner’s book Re-Inventing the Media is very timely. According to the publishers, Turner ‘takes on the task of rethinking how media studies approaches the whole of the contemporary mediascape.’ This statement should not lead the reader to expect that Turner is arguing for a root and branch overturning of how we approach and teach the media. Instead. it can be argued that this is rather a sober ‘re-think’ that seeks to address both the elements of change and continuity in teaching communication or media studies today.
REVIEW: Noted: Powerful, unadulterated insight into West Papua
Authors: Hutt Kendall Louise
Published: July 2017

The Earth Cries Out, by Bonnie Etherington. Auckland: Vintage, 2017, 285 pages. ISBN 978-0-14-377065-7BONNIE ETHERINGTON'S debut novel, The Earth Cries Out, may be fiction, but it tells the true, powerful, story of West Papua, a nation separated from its Pacific brothers and sisters by Indonesian repression. The novel also serves as a useful background tool for journalists and provides them with an opportunity to learn of the human rights violations in West Papua.