bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of homopolymerization kinetics and copolymerization with methyl methacrylate of diethyl 9-(methacryloyloxy)-2-oxo-nonylphosphonate, 9-(methacryloyloxy)-2-oxo-nonylphosphonic acid and diethyl 9-(methacryloyloxy)-nonylphosphonate
Authors: Chmela Štefan , Fiedlerová Agnesa , Liptaj Tibor , Catel Yohann , Moszner Norbert
Published: November 2017

The three polymerizable monomers diethyl 9-(methacryloyloxy)-2-oxo-nonylphosphonate M1, 9-(methacryloyloxy)-2-oxo-nonylphosphonic acid M2 and diethyl 9-(methacryloyloxy)-nonylphosphonate M3 are examined for their free radical polymerization and copolymerization activity in methanol between 40 and 65°C. Polymerization proceeds readily through a thermal free radical initiation. The intensity exponents for the monomer and initiator are only slightly over 1 and approximately 0.5, respectively. This is in accordance with the results typically observed for an ideal free radical polymerization with bimolecular termination. The kinetics of copolymerization with methyl methacrylate (MMA) are monitored by online 1H nuclear magnetic resonance (NMR) spectroscopy. Two copolymerization reactions for each pair of co-monomers are sufficient to evaluate the kinetic data using the Jaacks method, the Fineman-Ross method and the nonlinear least squares method. All three methods give similar results for particular monomer/MMA couples.
Wideband Inverted-L Microstrip-via-Fed Circularly Polarized Antenna with Asymmetrical Ground for WLAN/Wimax Applications
Authors: Chen Qiang , Zhang Hou , Yang Lu-chun , Li Bin-bin , Min Xue-liang
Published: November 2017

A design with wideband and circularly polarized radiation antenna from an open-slot antenna has been demonstrated in this paper. The proposed antenna, which consists of an open slot and an inverted-L strip feeding, provides a large bandwidth, which completely cover the Wimax (3.3–3.8 GHz) and WLAN (2.4–2.48 GHz) bands. The open slot is formed by an modified ground plane with a slit cut and monofilar spiral stubs employed, which fed by an asymmetrical inverted-L strip feedline using a via. As demonstrated, the CP operation was significantly improved by loading monofilar spiral stubs connected to the asymmetric feedline by means of a via. A parametric study of the key parameters is made and the mechanism for circular polarization is described. After optimization, the impedance bandwidth is approximately 3.78 GHz (2.12 to 5.9 GHz) and the 3 dB axial ratio bandwidth is approximately 2.75 GHz (2.2 to 4.95 GHz), which represent fractional bandwidths of approximately 94.3 % and 76.9 %, respectively.
Schreiben in Konstellationen
Authors: Sproll Monika
Published: November 2017

In this contribution, the travel diaries and notebooks in which Adelbert von Chamisso documented his three-year journey round the world are examined together as a stand-alone travel book. Throughout his travels, Chamisso developed and modified the method and organization of his writing process. The combination of aestheticizing depictions of nature and documentary natural research is preserved in the assemblage of his travel writing but is operationalized through various text forms and ways of recording.
The Book Report and the Use of Modern Technologies in the Presentation of the Book Exhibits
Authors: Hubáčková Vilma
Published: November 2017

The Book Report exhibition is an example of modern technologies serving the presentation of the book exhibits. The exhibition arranged for the 50th anniversary of the first competition for the Most Beautiful Czech Book of the Year occupied a special place in the context of book exhibitions more generally. It exceeded preconceived notions and was highly experimental in character. It consisted of three parts, related to each other thematically and chronologically: The Most Beautiful Czech Book of 2014, Fifty Years of the Most Beautiful Czech Book Competition and The Most Book. These parts corresponded to three chronological planes. These three planes linked together the historical perspective, the view of the current form of the book and a vision of future developments in the field. The exhibition used the most modern technologies and resources from the visual arts and at the same time the physical presence of the book as traditional paper media remains intact. The focal point of the exhibition was the process of digitisation of books, performed within the exhibition hall. The project has its own webpages that remain in existence after the exhibition had finished.
Utilisation of a Balanced Scorecard for Museum Management
Authors: Prokůpek Marek
Published: November 2017

The issues involved with the economic aspects of cultural institutions, their economic impact, and the measurement of their performance has basically only been given systematic attention during the past few years. Traditionally performance assessments are primarily connected with entrepreneurial subjects, which is why this assessment has been applied primarily to financial metrics. During the 1990’s, this issue started to be examined from a new perspective. The question arose as to whether it is realistic to restrict performance measurement only to financial indicators. More and more, the opinion began to spread that for measurement to be truly useful, it must also focus on nonfinancial indicators. Gradually this idea started to be promoted, primarily in the cultural and the artistic non-profit areas and also that it is necessary to pay the requisite attention to this topic. Several studies have been made and there have also been other kinds of attempts to measure their performance; the root of the problem is that in Czech museums there is no longer a single agreed-upon method for measuring performance. This study is focused on the use of the Balanced Scorecard method and on its application in the museum world and also on its use as a tool for managing, monitoring and planning.
Influence of long-term oral application of quinolones on the ECG curve in dogs
Authors: Cepiel A. , Noszczyk-Nowak A. , Cekiera A. , Popiel J. , Pasławska U.
Published: November 2017

The aim of the study was to analyse the influence of enrofloxacin and pradofloxacin administered orally for 14 days on the ECG in dogs. The ECG was performed before and after a 14 day period of quinolone administration. There was an increase in the QTc and the TpTe interval in the group treated with quinolones. QTc was prolonged by 24 ms (p=0.001). The TpTe interval was shortened, on average, by 6.55 ms (p=0.048). In the group treated with enrofloxacin, QTc was prolonged by 16.27 ms (p=0.006) and the TpTe interval was shortened by 9.64 ms (p=0.050), the TpTe/QT index was reduced by 0.034 (p=0.050) on average. In dogs treated with pradofloxacin, QTc was prolonged by 21.55 ms (p=0.012) on average. The results suggest that a prolonged administration of quinolones can increase the risk of arrhythmias. Furthermore, different generations of these drugs increase this risk to various degrees. The study proved that second generation quinolones, such as enrofloxacin, significantly change the phase of depolarization and repolarization of the ventricles, at the same time increasing the risk of ventricular arrythmia. Pradofloxacin does not change the TpTe and TpTe/QT values, so it is safer in use.
Application of loop-mediated isothermal amplification (LAMP) assays for the detection of bovine herpesvirus 1
Authors: Socha W. , Rola J. , Urban-Chmiel R. , Żmudziński J.F.
Published: November 2017

Bovine herpesvirus-1 (BoHV-1), a causative agent of Infectious Bovine Rhinotracheitis (IBR), is responsible for high economic losses in cattle farming industry. The use of testing methods that allow early detection of BoHV-1-infected animals is a key element of each program of IBR eradication. The aim of the study was to design and evaluate two variants of LAMP isothermal tests with SYBR Green fluorescence probes, specific to the genes encoding gD and gE glycoproteins of BoHV-1. LAMP gE BoHV-1 assay was able to distinguish between gE- and gE+ strains of the virus. Both LAMP gD and gE assays were specific to BoHV-1 and did not react with other related to BoHV-1 alphaherpesviruses. Sensitivity of LAMP gD was 2x104 copies of the viral genome whereas for LAMP gE it was 2x105. Diagnostic sensitivity calculated for LAMP gD was 64.7% whereas for LAMP gE it was 80%. Diagnostic specificity for LAMP gD and LAMP gE was 78.9% and 89.3%, respectively. LAMP assay can be a rapid and simple method of diagnosis of acute BoHV-1 infections and discrimination of gE- strains. However, relatively low diagnostic sensitivity of the method can limit its use in routine diagnostics.
Durchführbarkeitsstudie zur
Inline-Überwachung der Wärmeleitfähigkeit
und der strukturellen Qualität von Kunststoffen im
Heißextrusionsprozess mittels
Infrarot-Thermographie
Authors: Meinlschmidt Peter , Aderhold Jochen , Schlüter Friedrich
Published: November 2017

In der vorliegenden Arbeit wird über erste Ergebnisse eines
Forschungsprojektes zur prozessintegrierten Messung der
Wärmeleitfähigkeit von heißextrudierten Dämmstoffen
und zur Erkennung möglicher struktureller Fehler mittels eines
Wärmebildverfahrens berichtet. In Modellversuchen werden
Laserimpulse und Kühlfinger benutzt, um auf einem Förderband
transportierte Blöcke von Dämmstoffen positiv oder negativ
thermisch anzuregen. Mittels einfacher, aber robuster Algorithmen ist
es möglich, die Anregungsstellen automatisch zu erkennen und zu
verfolgen und die Entwicklung ihrer infraroten
Strahlungsintensitäten als Funktion der Zeit zu messen. Diese ist
ein Maß für die relativ komplexe Zeitabhängigkeit der
Oberflächentemperatur an den Anregungsstellen. Nach einer
wahrscheinlich durch die Semitransparenz des Materials bedingten
Anlaufphase folgt sie jedoch wenigstens für eine Zeit lang einer
gut verstandenen Proportionalität zu t
−0.5, aus der
sich die Wärmeleitfähigkeit bestimmen lässt. Damit sind
die Grundvoraussetzungen für eine Inline-Messung der
Wärmeleitfähigkeit mit diesem Verfahren gegeben.
Nano-colloidal silica-tethered polyhedral oligomeric silsesquioxanes with eight branches of 3-aminopropyltriethoxysilane as high-performance catalyst for the preparation of bis-thiazolidinones under ultrasonic conditions
Authors: Safaei-Ghomi Javad , Nazemzadeh Seyed Hadi , Shahbazi-Alavi Hossein
Published: November 2017

We report a class of organic–inorganic hybrid material based on nano-colloidal silica-tethered polyhedral oligomeric silsesquioxanes with eight branches of 3-aminopropyltriethoxysilane [nano-colloidal silica@APTPOSS (a series of polyhedral oligomeric silsesquioxanes with eight branches of 3-aminopropyltriethoxysilane)]. It was characterized by 1H NMR spectroscopy, dynamic light scattering, scanning electron microscope, energy dispersive spectroscopy and thermogravimetric analysis. An easy and rapid method for the synthesis of bis-thiazolidinones has been presented by one-pot pseudo-five-component reaction of benzaldehydes, ethylenediamine and 2-mercaptoacetic acid using nano-colloidal silica@APTPOSS. The reusability of the catalyst and little catalyst loading, excellent yields, short reaction times, using the sonochemical procedure as a green process and an alternative energy source are some benefits of this method.
The Efficient Removal of Heavy Metal Ions from Industry Effluents Using Waste Biomass as Low-Cost Adsorbent: Thermodynamic and Kinetic Models
Authors: Indhumathi Ponnuswamy , Sathiyaraj Subbaiyan , Koelmel Jeremy P. , Shoba Srinivasan U. , Jayabalakrishnan Chinnasamy , Saravanabhavan Munusamy
Published: November 2017

The ability of green micro algae Chlorella vulgaris for biosorption of Cu(II) ions from an aqueous solution was studied. The biosorption process was affected by the solution pH, contact time, temperature and initial Cu(II) concentration. Experimental data were analyzed in terms of pseudo-first order, pseudo-second order and intra particle diffusion models. Results showed that the sorption process of Cu(II) ions followed pseudo-second order kinetics. The sorption data of Cu(II) ions are fitted to Langmuir, Freundlich, and Redlich–Peterson isotherms, and the Temkin isotherm. The thermodynamic study shows the Cu(II) biosorption was exothermic in nature. The Cu(II) ions were recovered effectively from Chlorella vulgaris biomass using 0.1 M H2SO4 with up to 90.3% recovery, allowing for recycling of the Cu. Green algae from freshwater bodies showed significant potential for Cu(II) removal and recovery from industrial wastewater.
A personagem na obra de Ian McEwan: entre a culpa e o desejo de reparação
Authors: Zanatta Deisi Luzia , Souza Renata Junqueira de
Published: November 2017

Este artigo tem como objetivo analisar a trajetória da protagonista Briony Tallis e como se dá sua ação no romance Reparação (2002), de Ian McEwan. Na obra, a personagem principal influenciada por sua mente fantasiosa e uma leitura mal interpretada, vive um drama e tenta  reparar um erro cometido no passado. Para tal, o viés teórico adotado conta com os pressupostos de Krause (2010) sobre a metaficção; Rosenfeld (1969, 1976), Candido (1976), Forster (2005), Reis (2001), Miguel (2016) acerca da personagem de ficção, Reis & Lopes (1988) e Friedman (2002) sobre o foco narrativo e a voz do narrador. O trabalho evidenciou que Ian McEwan mostra, através da protagonista, a arte da literatura ao possibilitar uma possível identificação dos seres humanos com as personagens ficcionais.
Sebastião em O primo Basílio: Um caso exemplar de personagem secundária?
Authors: Fornos José Luís Giovanoni
Published: November 2017

O presente ensaio examina o conceito de personagem, interrogando acerca da sua importância na economia do texto narrativo. Ressalta sua estrutura à luz das concepções semiológicas de acordo com Philippe Hamon, bem como o papel do inconsciente na constituição do sujeito e sua relação com a dinâmica social. Igualmente observa o valor da recepção a partir de Wolfgang Iser e Umberto Eco. Para tais reflexões, se utiliza da personagem Sebastião, presente no romance O primo Basílio, de Eça de Queirós, enquadrando-a como figura de recalque do desejo amoroso, curvando-se aos preceitos morais da sociedade portuguesa oitocentista.
Quaderna, personagem-mosaico d’ A pedra do reino e a construção de memória sincrônica no romance
Authors: Cazumbá Renailda Ferreira , Da Silva Edvania Gomes
Published: November 2017

O romance d’ A Pedra do Reino, escrito por Ariano Suassuna, possui uma composição narrativa complexa e multifacetada que provoca reflexões acerca das da produção literária brasileira da década de 1970, época em que foi publicado. Dessa forma, este artigo possui a intenção de analisar a personagem Quaderna, um dos componentes-chave desse romance, com base na ideia de este se constitui em uma personagem-mosaico, a partir da qual o romance de Suassuna agrega várias visões de Brasil e constrói memória sobre o aspecto histórico e político do país a partir de 1930. Quaderna, por sua postura crítica e autoconsciente, de intrusão na trama e, ainda, o narrador que é responsável pela autoconstrução, participa do vasto painel das personagens complexas da literatura brasileira.
Conto de fadas
Authors: Rinaldi Azzurra
Published: November 2017

---
A personagem de autoficção: anotações de uma hipótese para textos futuros
Authors: Prelorentzou Renato
Published: November 2017

Este artigo tem o estranho intento de reunir algumas ideias iniciais para futuras abordagens sobre o fenômeno da autoficção. Sem desconsiderar o longo e polêmico debate em torno do termo, procura analisá-lo a partir da leitura do clássico A personagem de ficção e da ideia de insuficiência do conceito de fiction tal como proposto por Catherine Gallagher (2009). A maior tentativa é sugerir que o pacto ficcional forte e inequívoco que o romance firmou talvez seja uma exceção na história da literatura e que o pacto ambíguo que a autoficção agora propõe talvez seja uma espécie de reedição da instabilidade ontológica que foi suprimida pelo romance tradicional.
A personagem teatral e o pícaro espanhol em Dois perdidos numa noite suja, de Plínio Marcos
Authors: Rodrigues Sergio Manoel
Published: November 2017

Este artigo tem como objetivo apresentar as personagens Tonho e Paco da peça Dois perdidos numa noite suja (1966), do dramaturgo Plínio Marcos, estabelecendo uma comparação das mesmas com a figura do pícaro espanhol, cujos caracteres muito se aproximam aos dos seres plinianos. Desse modo, propõe-se, inicialmente, a abordagem das principais características da personagem teatral, a fim de se verificar os elementos que constituem o ser fictício na dramaturgia e, assim, analisar os perfis e as relações existentes entre as personagens da peça em questão. Evidenciando, portanto, a marginalidade social e suas consequências (agressões, roubo, assassinato) como as principais temáticas exploradas por Plínio e pela picaresca espanhola.
Technology Integration into Preservice Foreign Language Teacher Education Programs
Authors: Wildner Siegrun
Published: November 2017

Using national technology goals and standards, and institutional factors as a framework, this article describes the planning process and the initial phases of the implementation of a model of technology integration into the foreign language preservice teacher education program for K-12 teachers. It also provides suggestions for instructional goals and subject-related content areas for a curricular component on technology for foreign language teachers.
AVALIAÇÃO DA ISOMETRIA DO MÚSCULO TRANSVERSO ABDOMINAL EM UNIVERSITÁRIAS DO CURSO DE FISIOTERAPIA
Authors: Pereira Guilherme Veiga , Goulart Cássia Luz , Cruz Daniel Fernando , Carvalho Lisiane Lisboa
Published: November 2017

Introdução: Uma abordagem alternativa pode ser a unidade de pressão por biofeedback (PBU) cuja medição é indireta avaliando a atividade do transverso do abdômen através de mudanças de pressão da parede abdominal.Objetivo: reconhecer as Universitárias do curso de fisioterapia que se apresentam com baixo nível de atividade física e deficiência de ativação do transverso do abdômen. Materiais e Métodos: Estudo transversal, com amostra por conveniência e não probabilística, composta de 49 universitárias jovens (22,0±3,7 anos; 1,62±0,5m; 58,6±10,1kg; IMC= 22,0±3,5) matriculadas no Curso de Fisioterapia da UNISC. Foi aplicado o questionário internacional de atividade física (IPAQ), respondido o questionário, a universitária era questionada quanto à presença de dor lombar, quantificando a mesma pela Escala Visual Analógica (EVA) e, então era realizado o teste com biofeedback (PBU) em decúbito ventral. Resultados: Foi observado que das 49 participantes do estudo, 35 (72,43%) destas apresentaram ativação do Transverso do Abdômen (TrA) e 14 (27,57%) ficaram fora dos padrões de ativação muscular. Além disso, foi evidenciado que universitárias obesas conseguiram manter por mais tempo a contração do TrA (p=0,05) e universitárias que possuem mais idade são mais ativas (p=0,04). Conclusão: Estes achados sugerem que universitárias que apresentam baixo nível de atividade física apresentam boa ativação do TrA e que as obesas tiveram uma variação menor de pressão.
Impairment of the in vitro Release of Carbamazepine from Tablets
Authors: Uzunović Alija , Vranić Edina , Hadžidedić Šeherzada
Published: November 2017

Carbamazepine belongs to the class II biopharmaceutical classification system (BCS) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. The bioavailability of such a drug is limited by the dissolution rate. The present study deals with the formulations of immediate release tablets of poorly soluble carbamazepine. As model tablets for this investigation, two formulations (named “A” and “B” formulations) of carbamazepine tablets labeled to contain 200 mg were evaluated. The aim of this study was to establish possible differences in dissolution profile of these two formulations purchased from the local market.The increased crystallinity together with enlarged particle size, enhanced aggregation and decreased wettability of the drug, resulted in insufficient dissolution rate for formulation “B’.’ From the dissolution point of view, this formulation was inferior to the formulation “A, due to the solubilization effect.
Immunohistochemical staining of insulin and glucagon in islets of formalin-fixed human pancreas v1
Authors: Starrs Lora , Brown Debra , Popp Sarah , Simeonovic Charmaine
Published: November 2017

Insulin and glucagon hormones were detected in paraffin sections (4 μm thickness) of formalin-fixed human pancreases. Insulin and glucagon were detected immunohistochemically using mouse anti-human insulin mAb (ascites; Sigma) and mouse anti-porcine glucagon mAb (ascites; Sigma), respectively, with biotinylated anti-mouse IgG and avidin-biotin-complex (ABC reagent; PK-2200, Vector Labs). Background staining was checked using the corresponding isotype control Ig instead of the primary antibody. 3-amino-9-ethylcarbazole (AEC) was used as the chromogen. Stained sections were imaged using a light microscope with attached camera (Olympus BX41).
HBV DNA Real Time Quantification according to ARNS 12187 project v1
Authors: Bivigou-Mboumba Berthold , François-Souquière Sandrine , Deleplancque Luc , Sica Jeanne , Mouinga-Ondémé Augustin , Amougou-Atsama Marie , Laure Chaix Marie , Njouom Richard , Rouet François
Published: November 2017

HBV DNA Real Time Quantification according to ARNS 12187 project Using the Arrow extractor (NorDiag, Biotrin International, Ireland), DNA was extracted from 240 μl of plasma, pre-treated with10 μl of proteinase K, using the Arrow Viral NA extraction kit, according to the manufacturer’s instructions during 45 min. Template DNA was eluted into 60 μl of kit elution buffer. Besides clinical samples, quantification standard (Acrometrix HBV Panel, Acrometrix, Menica, CA, USA) was also extracted for each run with the same protocol and1:10 diluted (from 50,000,000IU/mL to50IU/mL). For amplification, we used a primers/probe set designed under the auspices of “Agence Nationale de Recherches sur le SIDA et les hépatites virales” (ANRS 12187 project) and targeting a conserved region in the HBVS gene (nucleotide (nt) positions, 379–426). All runs were performed in a 50-μl volume containing DNA extract (10 μl), Master Mix (Platinum UGD, USA) (25 μl), pure water (HyClone Pure Water, Thermo Fisher Scientific, Waltham, MAUSA)(12.5 μl), forward primHBV1 (5’-GTGTCTGCGGCGTT TTATCA-3’) and reverse primHBV2 (5’-AGGCATAGCAGCAGGAT GAA-3’) primers at 10 μM (1μl each) and probe (5’FAM-TGCGGCGTTTTATCAT-MGB3’) at 5μM (0.5 μl). Each reaction consisted of: 2min at50°C and 10min at95°C; followed by 50 cycles of 15sec at 95°C and 1 min at 60°C each. The lower limit of quantification (LLOQ) of our technique was 100IU/mL and the lower limit of detection (LLOD) was 50IU/mL.
Psychometric properties of the Portuguese version of the Relational Interdependent Self –Construal scale
Authors: Gonçalves Gabriela , Sousa Cátia , Santos Joana , Gomes Alexandra , Santa-Rita Andreia , Hipólito Sofia , Rodrigues Catarina , Reis Marta
Published: November 2017

Relational interdependent self-construal (RISC) can be described as the degree to which the individuals define themselves in terms of their intimate relationships. Due to the significance that this construct and its associated measurement, the RISC scale, have in individual and social processes, we conducted two studies in order to validate the scale for the Portuguese population. The 11 item one-dimensional RISC scale was translated into Portuguese and its psychometric properties were analysed with two samples: 399 participants for Study 1 (62.9% women and 30.8% men, aged between 18 and 59 years - M = 26.4; SD = 8.90) and 292 participants for Study 2 (57.9% women and 42.1% men, aged between 17 and 59 years - M = 26.37; SD = 8.87). The results confirmed the one-dimension scale structure, showing good values of validity and model adjustment (CFI = 0.92; TLI = 0.87; NFI = 0.89; RMSEA = 0.09). The RISC-P scale proved to be invariant between gender, and significant differences between genders were found, notably that women have higher values of RISC. The good psychometric indicators and model adjustment validates the use of this version for the Portuguese population in many research settings (e.g. control for social desirability effect, analysis of convergent and predictive validity).
Breaking the Barrier—PEGylated Recombinant Human Hyaluronidase (PEGPH20)—A New Therapeutic Approach to the Treatment of Pancreatic Ductal Adenocarcinoma
Authors: Hendifar Andrew , Bullock Andrea ,   Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, US,   Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, US
Published: November 2017

New therapeutic approaches are urgently needed to improve survival for patients with metastatic pancreatic ductal adenocarcinoma (PDA). This carcinoma is characterized by a hyaluronan (HA)-rich desmoplastic stroma that raises tumor interstitial fluid pressure (IFP), which in turn compresses the vasculature and impedes access of anti-cancer therapies and immune cells to tumor sites. It is this biophysical barrier that is the target for PEGylated recombinant human hyaluronidase (PEGPH20; pegvorhyaluronidase alfa), which degrades HA polymers to tetra- and hexa-saccharides to remodel the tumor stroma. In preclinical models, PEGPH20 reduced IFP, and expanded tumor vasculature to improve perfusion, which increased access for innate immune cells, antibodies and therapeutic agents. The results of a phase Ib study have suggested benefits in overall survival and progression-free survival (PFS) for patients with tumors that accumulate HA (termed HA-High) treated with a combination of gemcitabine and PEGPH20. A phase II study (HALO 109-202) demonstrated that HA could be a potential biomarker for identifying patients who may be most suitable for PEGPH20 treatment. HALO 109-202 showed positive outcomes for PFS especially in HA-High patients treated with PEGPH20 plus nab-paclitaxel and gemcitabine. A randomized, double-blind, phase III study (HALO 109-301) exploring the benefits of PEGPH20 in HA-High patients with PDA is ongoing. Other PEGPH20-based combinations are being investigated in multiple stroma-rich cancers, including lung, gastric, and breast. PEGPH20 is the most advanced therapy targeting the tumor stroma and has the potential to form the therapeutic backbone for the treatment of stroma-rich tumors.
Adrenal Oligometastases Secondary to Non-small Cell Lung Cancer—What is the Optimal Treatment Approach?
Authors: Thomsen Bryce , Fairchild Alysa ,   Faculty of Medicine, University of Alberta, Edmonton, AB, Canada,   Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB, Canada
Published: November 2017

Background: Five-year overall survival (OS) for patients with stage IV non-small cell lung cancer (NSCLC) is a dismal 1%. However, approximately 7% have limited or solitary metastases, including to the adrenal gland. Radical treatment of these oligometastases (OM) could increase local control and improve OS. Our objective was to critically analyze data describing aggressive treatment of adrenal OM secondary to NSCLC. Methods: A literature search examining English publications describing surgery or radiotherapy (RT) was performed, supplemented by searching reference lists. Case reports of three or fewer patients, and articles from which NSCLC- or adrenal-specific clinical outcomes could not be abstracted, were excluded. Results: Twenty-nine studies met eligibility criteria (521 patients), 26 retrospective. No publications directly compare modalities. Four surgery studies described contemporaneous patients treated with palliative chemotherapy (CH) alone. Reported median OS ranged from 9.5–64 months after adrenalectomy, 8–23 months after RT, and 6–8.5 months after CH. Local failure after surgery was 14%, with response rates after RT 57–75%. Both appear well-tolerated. Conclusions: In patients with an adrenal OM secondary to NSCLC, aggressive treatment should be considered. However, due to the paucity of high quality evidence, it is unclear at present whether this approach alters the natural history of the disease.
Study of clinical presentation of falciparum malaria and correlation with laboratory indices of poor prognosis
Authors: Choudhary Hazarimal , Choudhary Prema Ram
Published: November 2017

Background: Severe malaria is a chief cause of death in the North-eastern states of India. The criteria for defining severe malaria have fluctuating over the last many years. Detection of both specific and sensitive clinical features of falciparum malaria to predict death is required to improve clinical management. Therefore, the objective of present study was designed to investigate the clinical presentation of falciparum malaria and correlation with laboratory indices of poor prognosis.Methods: This prospective observational study was conducted at the R N T Medical College Udaipur, India. Total 53 malarial patients who tested positive for plasmodium falciparum were included. A detailed clinical presentation, haematological and biochemical variables were scrutinized. SPSS-16 software was used for statistical analysis.Results: Out of 53 patients, 6 (11.3%) patients had (>5%) parasitaemia, 3 (5.66%) patients had schizonts in peripheral blood film, 2 (3.77%) patients had serum creatinine >3.0 mg%, 4 (7.54%) patients had raised SGOT and SGPT and all have been died while 11 (20.75%) patients had haemoglobin <7.1 gm% and amongst these 3 (27.27%) patients were died. Out of 53 patients, 13 patients (24.53%) died. Most of the patients had over lapping features with anemia (13.32%), ARDS, 16.98 %, Jaundice 9.43% and impaired consciousness (32.96%). These four features were responsible for high incidence of mortality in malaria.Conclusions: Decisively 29 (54.71%) patients were having laboratory indices of poor prognosis and amongst them 19 (65.51%) patients were died. Therefore, our findings confirm that patients who had P. falciparum malaria with laboratory indices of poor prognosis had high incidence of mortality.
Coagulopathy secondary to chicken pox: a case report
Authors: Kaur Harharpreet , Mohan Gurinder , Singh Harsehaj , Singh Gurraj , . Anusha
Published: November 2017

Chickenpox often produces a self-limiting disease in children and adolescents. The clinical course is usually mild and complications are rare. The complications that are known to be associated with it are pneumonia, meningitis, myocarditis and nephritis. Severe and disseminated varicella infection with organ dysfunction can also be seen amongst diabetics and immunocompromised patients. However, it is not commonly known that varicella can be life threatening even in immunocompetent adult patients. We present a case of a healthy adult male in which this infection progressed to malignant hemorrhagic disease associated with coagulopathy.
A tolerância na educação como meio de defesa de direitos humanos: proposições acerca do eixo educacional do plano estadual de políticas públicas LGBT do Paraná 2013-2015
Authors: Turatti Junior Marco Antonio , Machado Edinilson Donisete
Published: November 2017

O presente artigo discute a implementação de valores sobre a tolerância na base principiológica da educação, a fim de que as políticas públicas de caráter educacional promovidas pelo governo consigam ser autossustentáveis e efetivas ao passar do tempo. Analisando este fator filosófico de aceitação da diferença e o respeito, a tolerância demonstra o caminho para a melhoria da harmonia social coletiva hoje atacada pelo preconceito e homofobia destinada ao grupo LGBT. Assim, dessa maneira, converge-se as duas áreas temáticas deste desenvolvimento científico a fim de compreender a importância de tais valores na formação básica educacional e no ambiente escolar, tanto de maneira formal como material.
Les Rondes paysannes
Authors: Villas Bôas Filho Orlando
Published: November 2017

ORIGINAL PICCOLI, Emmanuelle. Les Rondes paysannes. Vigilance, politique et justice dans les Andes péruviennes. Louvain: L’Harmattan/Academia, 2011, 168 p.
Análisis económico del régimen jurídico de la protección de usuarios de las telecomunicaciones en Colombia
Authors: Bejarano Daza Ángela
Published: November 2017

El impacto de la regulación sobre el cumplimiento de las normas que protegen los derechos de los usuarios de comunicaciones no es muy positivo. A pesar de que las multas impuestas a los proveedores de servicios disidentes de la regulación de protección de los derechos de los usuarios sean cada vez más altas y reiterativas, estos siguen prestando servicios sin calidad y aún es evidente el irrespeto de los derechos de los usuarios. En el sector de las telecomunicaciones, este fenómeno se fundamenta en el comportamiento clásico y racional de los proveedores de servicios, quienes como agentes del mercado y en ejercicio de la competencia, dentro de sus estrategias de juego, el juego dominante es su preferencia por el incumplimiento de la Regulación de Protección de los Derechos de los Usuarios de los Servicios de Comunicaciones, dado que el costo (las sanciones pecuniarias) nunca será mayor al beneficio reportado con el incumplimiento (utilidades).
m- commerce. El comercio electrónico móvil y los pagos a través de dispositivos móviles
Authors: Imbachí Jair Fernando
Published: November 2017

El comercio electrónico debe armonizarse con las tendencias globales, a razón de la gran expansión y acogida con que cuentan, incluso en países en vías de desarrollo, los servicios móviles y dispositivos de nueva tecnología como son los teléfonos inteligentes y tabletas. La ausencia de una legislación uniforme que consagre los derechos y deberes de los agentes del mercado constituye una barrera al incremento y desarrollo del comercio electrónico. Al respecto, Colombia quiere proponer ante la CNUDMI, la realización de un estudio para unificar, no solo las preocupaciones de los consumidores, sino también las de los operadores legales, en materia de comercio móvil y pagos a través de dispositivos móviles.
Instituciones formales de la gobernanza metropolitana en Colombia: un análisis de elección racional
Authors: Roldán Alzate Luis Miguel
Published: November 2017

En este artículo se indaga por las condiciones necesarias para la cooperación de municipios colindantes en la integración de áreas metropolitanas en Colombia a partir de una revisión, bajo el marco analítico del institucionalismo de elección racional, de las principales teorías sobre el gobierno metropolitano y la normativa vigente relacionada con la jurisdicción metropolitana en el país. Se concluye que la conformación de un área metropolitana en Colombia obedece a la existencia de beneficios extraordinarios para los municipios participantes, y que el fortalecimiento de la gobernanza metropolitana depende, bien del mantenimiento de dichos beneficios o bien de un fortalecimiento de los mecanismos de veeduría que modifiquen los incentivos a los hacedores de políticas.
A Discrete Approach to Meshless Lagrangian Solid Modeling
Authors: Marko Matthew
Published: November 2017

The author demonstrates a stable Lagrangian solid modeling method, tracking the interactions of solid mass particles rather than using a meshed grid. This numerical method avoids the problem of tensile instability often seen with smooth particle applied mechanics by having the solid particles apply stresses expected with Hooke's law, as opposed to using a smoothing function for neighboring solid particles. This method has been tested successfully with a bar in tension, compression, and shear, as well as a disk compressed into a flat plate, and the numerical model consistently matched the analytical Hooke's law as well as Hertz contact theory for all examples. The solid modeling numerical method was then built into a 2-D model of a pressure vessel, which was tested with liquid water particles under pressure and simulated with smoothed particle hydrodynamics. This simulation was stable, and demonstrated the feasibility of Lagrangian specification modeling for fluid–solid interactions.
Surface Property Modification of Polylactic Acid by Ion Implantation
Authors: Vasenina Irina , Savkin Konstantin , Laput Olesya , Zuza Daniil , Kurzina Irina
Published: November 2017

We describe our investigations of the surface physicochemical and biological properties of polylactic acid modified by silver, argon and carbon ion implantation to doses of 1 × 1014, 1 × 1015 and 1 × 1016 ion/cm2 at energies of 20 keV (for C and Ar) and 40 keV (for Ag). X-ray analysis shows enhancement of coherent scattering regions and lattice constant increase after ion implantation. Secondary electron mass-spectrometry indicates that Ag concentration in the subsurface layer is less than 80%, but at a depth of 500 nm does not exceed 1–2%. The silver forms metal particles in the subsurface layer rather than making additional chemical bonds with polymer atoms. Atomic force microscopy reveals that the higher the irradiation dose the larger the surface roughness of the samples. Ag-irradiated samples implanted to a dose of 1 × 1016 ions/cm2 have the highest roughness, 190 nm. Our investigation of the cytotoxicity of two individual donor macrophages shows that Ag-implanted polylactic acid has no negative impact on immune system cells and could be a promising material for biomedical application.
Continuous Inclination Measurements and BHA Modeling Help Detect Microdoglegs
Authors: Wilson Adam
Published: November 2017

This article, written by Special Publications Editor Adam Wilson, contains highlights of paper SPE 184074, “Microdogleg Detection With Continuous Inclination Measurements and Advanced BHA Modeling,” by K.A. Mills, SPE, and S. Menand, SPE, DrillScan, and R. Suarez, SPE, Nabors, prepared for the 2016 SPE Eastern Regional Meeting, Canton, Ohio, USA, 13–15 September. The paper has not been peer reviewed.

Microdoglegs are a natural effect of any vertical or directional well that can explain a wide variety of downhole problems. A trajectory-prediction model able to calculate the inclination and azimuth approximately every 12 in. has been developed to estimate microdoglegs using standard surveys, bottomhole-assembly (BHA) data, and steering parameters. This new methodology combining downhole data measurements with drillstring-modeling analysis highlights the potential for drilling optimization and wellbore placement.

Wellbore Trajectory

Standard Surveys. Surveys are generally taken at an interval of every 95 ft, the length of one stand. While the general recommendation is to decrease the survey interval when building faster than 3°/100 ft, this is often neglected because there is no advantage seen in wellbore-positioning-uncertainty models.

The well path between each survey point typically is calculated using the minimum-curvature approach, which assumes a curve of equal angle along the surface of a sphere with only one radius in a 3D plane. Looking at the well as a whole, this approach appears logical and yields reasonable-looking trajectories; however, when examining more-frequent survey data, it becomes obvious how this method can mislead users to think that the well path is much smoother than it actually is.  Continuous-survey measurements have enabled the industry to take a closer look at what is happening between survey points, in highlighting microdoglegs quite often undetected by standard surveys.

Continuous Surveys. Doglegs are generally discussed on a well level. Wells are analyzed for tortuosity looking at the change in trajectory from one survey point to the next. Little thought is given to what changes happen between those points unless a dysfunction occurs. Aggressive directional work can lead to the creation of microdoglegs, or doglegs on a scale of a few feet. Quick changes in direction create microdoglegs, which can contribute overall to higher torque and drag.

In examining continuous surveys, the actions of the directional driller can be seen clearly and doglegs can be examined more closely. While continuous-survey data have become more common in the industry, not all measurement-while-drilling (MWD) tools are equipped for the measurements and, generally, data must be processed at surface on the basis of the previous survey. In the absence of continuous-survey data, BHA modeling run on a step-by-step basis can aid in wellbore placement, failure analysis, and post-well evaluation.
Phenology and Biomass Production of Adapted and Non‐Adapted Tropical Corn Populations in Central Iowa
Authors: Infante Pedro Alexander , Moore Ken J. , Lenssen Andrew W. , Archontoulis Sotirios V. , Scott Paul , Fei Shui‐zhang
Published: November 2017

Core Ideas

The accuracy of the Leaf Collar Method was refined.

Tropical corn adaptability investigated in central Iowa.

Non‐adapted tropical corn had greater non‐grain and total biomass as compared to their non‐adapted counterparts.

Taller tropical corn populations had the greatest biomass.

Greater non‐grain biomass occurs at the expense of grain yield.

Tropical corn biomass has potential as Gen2 biofuel feedstock.

Biofuel production in the midwestern United States has largely focused on corn (Zea mays L.) grain for ethanol production and more recently, corn stover for lignocellulosic ethanol. Tropical corn refers to corn adapted from tropical regions. Growing tropical germplasm in temperate environments is not attractive for grain yield, but shows promise for biomass production through taller and more vigorous plants with thick stems and long leaves. The comparison between tropical corn populations and their temperate adapted counterparts with a focus on biomass production has not yet been explored under Iowa growing conditions. This study refines the accuracy of the leaf collar method, and characterizes the adaptation of the populations by evaluating crop development and biomass production. Therefore, field trials were established in central Iowa during the 2014 and 2015 growing seasons. Adapted and non‐adapted versions of three populations, Tuxpeño, Suwan, and Tuson, were planted at three dates to evaluate their phenology and potential for biomass production under midwestern U.S. conditions. Plant height correlated well with vegetative development and total biomass. Adapted tropical corn had advanced grain development, while non‐adapted tropical corn had advanced vegetative development and greater biomass yield. Non‐adapted tropical corn flowered later, had 22% greater total biomass on average (4.6 Mg ha−1 greater than adapted), and had 43% greater non‐grain biomass on average, up to 20 Mg ha−1 (6 Mg ha−1 greater than adapted), while adapted populations yielded more grain. Non‐adapted tropical corn has a high potential as feedstock for Gen2 biofuels in central Iowa.
Do Soil Tests Help Forecast Nitrogen Response in First‐Year Corn Following Alfalfa on Fine‐Textured Soils?
Authors: Walker Zane T. , Coulter Jeffrey A. , Russelle Michael P. , Venterea Rodney T. , Mallarino Antonio P. , Lauer Joseph G. , Yost Matt A.
Published: November 2017

Core Ideas

ISNT and PSNT concentrations did not differ among alfalfa stand ages in five long‐term trials.

Only PSNT concentration increased during first‐year corn in three of five long‐term trials.

The PSNT was less related to soil N mineralization and more related to available N than the ISNT.

The PSNT more accurately predicted corn response or nonresponse to fertilizer N than the ISNT.

The product of alfalfa stand age and PSNT separated N response in 87% of 15 independent site‐years.

Improved methods are needed to predict grain yield response to fertilizer N for first‐year corn (Zea mays L.) following alfalfa (Medicago sativa L.) on fine‐textured soils. Data from 21 site‐years in the North Central Region of the United States were used to determine how Illinois soil nitrogen test (ISNT) and pre‐sidedress soil nitrate test (PSNT) concentrations change during alfalfa–corn rotations and how they relate to mineralized N, available N, and grain yield response to fertilizer N in first‐year corn. In five long‐term crop rotation trials, ISNT and PSNT taken in the alfalfa phase did not change with alfalfa stand age, but PSNT concentration in first‐year corn increased with alfalfa stand age in three of five trials. Across 21 site‐years, the PSNT more accurately predicted corn response or nonresponse to fertilizer N than the ISNT (67 vs. 52% of site‐years). The interaction of PSNT with alfalfa stand age resulted in 87% accuracy when validated with 15 independent site‐years; no N response was likely in first‐year corn when the product of PSNT × stand age exceeded 42. Incubation of soil from first‐year corn showed that the ISNT explained over twice as much variation in soil nitrate‐N accumulation after 17 wk than the PSNT (30 vs. 13%). Overall, the PSNT was less related to soil N mineralization and more related to aboveground corn N uptake, total available N, and grain yield response to fertilizer N in first‐year corn than the ISNT. This research provided a simple method for predicting when N response is likely in first‐year corn after alfalfa, but further research is needed to predict the size and mineralization rate of soil N pools after alfalfa termination to estimate the economically optimum nitrogen rate when fertilizer N response is likely.
Diversity of fungi in bottled water in Jeddah, Saudi Arabia
Authors: Ameen Fuad , Albejad Alhanouf , Gashgari Rukaia , Murialdo S. , Al-Sabri A.
Published: November 2017

The occurrence of fungi in drinking water systems has received increased attention over recent decades and fungi are now generally accepted as drinking water system contaminants. However, fungal contamination of bottled water has received little attention. Forty unopened bottled water samples, of different trademarks, were collected from various localities in Jeddah city, Saudi Arabia and analyzed for fungal contamination: (1) immediately after opening the bottles; and (2) after closing and storing them for 180 and 365 days. The fungal species were identified under a compound microscope followed by molecular sequencing. At least one fungal species were found in 58% of the bottles. In total, 18 fungal species belonging to 11 fungal genera were identified. Rhizopus nigricans and seven different species of Aspergillus were found to frequently contaminate the bottled water samples. Penicillium sp. were found in one sample. The 180 days storage of opened and reclosed bottles did not substantially affect the abundance of fungi or the species found. Some of the fungi identified may be pathogenic and the contamination of fungi in bottled water should be considered during the processing of water.
Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays
Authors: Korecká Lucie , Vytřas Karel , Bílková Zuzana
Published: November 2017

Cancer is a widespread disease characterized by high mortality. To improve the
survival rate or facilitate effective therapy, accurate and reliable diagnosis at an early
stage is needed. For this reason, there is a continuous push to develop sensitive methods
which can be used in cancer diagnosis. Current diagnosis relies on the quantification of
cancer biomarkers defined as molecules that are measurable in body fluids or tissues and
indicate a change in physiological processes with subsequent pathological manifestations.
This contribution reviews recent developments in the area of electrochemical immunosensors
applicable for the detection of cancer biomarkers that occur in a wide concentration
range including extremely low levels, which are typical for the early stage of the disease.
A summary of various antibody labels used for biomarker analysis and combined with
electrochemical detection is presented. The potential of multiple biomarker analysis, with
its indisputable clinical impact for accurate diagnosis, is also highlighted.