bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment Of Platelet Count And Its Correlation With Severity Of Pre-Eclampsia
Authors: Dr. Manisha Laddad  , Dr. Gauri shinde/pawar  , Dr. Yamini Patil  , Dr. Sanjaykumar Patil
Published: November 2022

Background: Pregnancy induced hypertension (PIH) is the most common medical disorder of pregnancy. The present study wasconducted to assess platelet count and its correlation with severity of pre-eclampsia.Materials & Methods: 108 suspected cases of pregnancy induced hypertension (cases) and group II had controls were assessed forplatelet count.Results: Age group 20-25 years had 14 cases of mild PIH, 24 of moderate and 6 of eclampsia. 26-30 years had 16 cases of mild, 22 ofmoderate and 4 cases of eclampsia and 31-35 years had 6 of mild, 14 of moderate and 2 of eclampsia. Group II had 56, 42 and 10respectively.Conclusion: Estimation of platelet count being simple economical and rapid investigation can be used for early detection of severity ofpreeclampsia. There were more cases of preeclampsia with low platelets.
Comparison Of Hyperbaric Bupivacaine In Conventional Dose To Isobaric Levobupivacaine Used For Infra Umbilical Surgeries
Authors: Dr Geetha S. Hasaraddi  , Dr. Vinod Kumar V S  , Dr. Prashanth Vadigeri  , Dr. Achyutha J
Published: November 2022

Background: For spinal anesthesia, levobupivacaine is considered an effective alternative anaesthetic agent to conventional bupivacaineowing to the faster recovery profile and lower probability of cardiovascular toxicity.Aim: To comparatively assess the analgesic and hemodynamic features of conventional dose of hyperbaric bupivacaine to isobariclevobupivacaine used for infra umbilical surgeries.Methods: The present clinical study included 120 subjects from ASA I and ASA II categories presented for elective infra umbilicalsurgeries and were randomly divided into 2 groups of 60 subjects each. Group, I subjects was given 0.5% hyperbaric bupivacaine atthe dose of 3ml, and Group II was given 0.5% isobaric levobupivacaine at the dose of 3ml. Hemodynamic parameters including SpO2,NIBP, and heart rates were assessed every 15 minutes till 2 hours postoperative. Side effects including nausea and vomiting,bradycardia, and hypotension were also evaluated.Results: Sensory block onset was slower in the levobupivacaine group and sensory block levels were comparable. For levobupivacaine,analgesia duration was significantly lower. With levobupivacaine, shorter motor blockade duration and slower motor blockade onsetwere seen. Complete motor blockade was seen in all subjects. Concerning hemodynamic parameters, lesser incidence of bradycardiaand hypotension and high cardiovascular stability. No incidence of PDPH, shivering, nausea, or vomiting was seen in any subject.Conclusion: The present study concludes that significantly similar effects concerning analgesia duration are seen with Bupivacaine aswith levobupivacaine. However, Bupivacaine showed better cardiovascular stability making Levobupivacaine use successful for lowerabdominal surgeries.
Caste, Impurity And Untouchability: Study Of Ants Among Elephants
Authors: Sree Harsha Sree Hari  , Surbhi Saraswat  , Prem Kumari Srivastava
Published: November 2022

Sujatha Gidla's autobiography, Ants among Elephants broadly discusses the idea of purity and impurity, and how it has dominatedthe age-old caste narrative. The memoir focuses on the lives of her parents, grandparents and their resultant inner turmoils. Thepurpose of this research paper is to examine the lives of indigenous people and their struggles in relation with caste hierarchy. Thispaper will examine the lives of lower caste Indians in the pre - independence era through the memoir of Sujatha Gidla.
A Comparative Analysis Of Interval Cholecystectomy And Early Cholecystectomy Among Patients Of Acute Cholecystitis At A Tertiary Care Centre
Authors: Dr.Parthasaradhi Reddy  , Dr S J Bhosale  , Dr. Aakash Katkar
Published: November 2022

Background: Comparative evaluation of the efficacy of Interval Cholecystectomy and Early Cholecystectomy Among Patients of AcuteCholecystitis.Materials & methods: A total of 100 patients with presence of acute cholecystitis were analysed. All the patients were broadly andrandomly divided into two study groups as follows: Group A: 50 patients who were schedule to undergo interval cholecystectomy,andGroup B: 50 patients who were schedule to undergo early cholecystectomyComplete history of all the patients was obtained. Allpatients were subjected to detailed history including, chief complaints, history of present and past illness, personal history, familyhistory, treatment and drug history. All the operative procedures were carried out under the hands of skilled and experienced surgeons.Follow-up was done and complications (if any) were recorded separately. All the results were recorded in Microsoft excel sheet andwere analysed by SPSS software.Results: Occurrence of postoperative wound infection and biliary leaks was higher among the patients of group B in comparison topatients of group A.Mean hospital stay among the patients of group A and group B was 5.6 days and 9.1 days respectively. Whilecomparing statistically, significant results were obtained.Conclusion: Interval Cholecystectomy shows better results in comparison to Early Cholecystectomy among patients of AcuteCholecystitis in terms of occurrence of postoperative complications and shorter duration of hospital stay.
Biochemical And Heamatological Evaluation Pattern Of Pentostam- Induced Hepatotoxicity And Nephrotoxicity In Albino Mice
Authors: Nouara Elazirg Elammari  , Mariam Ambarak S. Busaadia  , Yousif Sulaiman  , Munay Younus Al Abbar  , Ghazala Othman Omar
Published: November 2022

This study was designed to examine the effect of different dose of Pentostam administration in male albino mice as a model, todetermine their effect on some biochemical and heamatological parameters. 28 adult male of BALB/c wild mice aged 8- 12 weeks andweighing 25-39 gm were used and i.p. injected with 10mg/kg, 20mg/kg, and 40mg/kg pentostam in addition to a control group. After28 therapeutic days, blood sample were collected from each animal. The result of Biochemical Index of the serum obtained showedthat there were increase significant differences between different concentration doses on AST, ALT, ALP, Urea, Creatinine and BUNas compare to control group at (p >0.01). Conversely in case of Albumin and Total protein were the result showed decrease significantdifference between different concentration doses on this parameter as compare to control group of the same at (p> 0.01). while nosignificant differences between the different concentrations group of doses on Total bilirubin, where the F value was (1.00). The resultof Hematological Index of blood sample showed that there were decrease significant difference at (P ≤ 0.01-0.05) in hemoglobin, HCT,WBCs, LYM and MON concentration in the different concentrations dose of treatment as compared to control group. Conversely, forMCHC, NEU and EOS there were increase significant difference at (P ≤ 0.05-0.01) as compared to the control group. While nosignificant changes (P ≤ 0.0-01.05) in the parameters of RBCs, MCV, MCH, BAS count and Platelet were found when compared withcontrol animals. Biochemical and hematological evaluation pattern still an important role to evaluate drug toxicity. However, theresults of this study concluded that, different doses of Pentostam can cause hepatotoxicity and nephrotoxicity. Therefore, it will beimportant of change in anti-leishmanial regimen to reduce their side effect
Synthesis, Structural Characterization Of Benzothiazole Schiff Base Metal (II) Complexes And Their Interaction With DNA
Authors: Patil Pratiba  , Virupaxappa S. Betageri  , M. S. Latha  , Shridhar A H
Published: November 2022

A potential metal-based chemotherapeutic product based on a benzothiazole Schiff base and first-row transition metals was synthesizedand illustrated analytically and spectrally to investigate the biochemical priority of transition-metal drugs for molecular target DNA.As a result of the magnetic susceptibility data, it was shown that Co (II), Ni (II) and Cu (II) complexes are paramagnetic and have anoctahedral geometry at ambient temperatures. Molar conductivity experiments showed that almost all of the complexes in dimethylformamide were non-electrolytes. This study examined the interactions between CT-DNA and metal (II) complexes. Therefore, thecopper(II) complex significantly improves DNA binding compared to the other complexes. Additionally, this finding was supported bygel electrophoresis, thermal denaturation, and viscosity methods.
Barriers To Exclusive Breastfeeding Among Mothers With Children Aged 6-9 Months In Mogadishu City, Somalia
Authors: Deka Abubakar Gaal
Published: November 2022

Exclusive breastfeeding (EBF) in the first six months of life is the most effective way to satisfy a baby's nutritional and psychologicalneeds. It is a simple intervention to improve a child's health and development. Despite its advantages, there is a low global rate ofexclusive breastfeeding (EBF), and in Mogadishu, Somalia, EBF is rarely practised. This research identified social and cultural factorsthat might influence the practice of exclusive breastfeeding among mothers with babies aged between 6-9 months in Mogadishu, toinform and support redress.MethodsA community-based cross-sectional study was conducted among mothers of 280 infants aged six months to 9 months. Mothers wererecruited using a consecutive sampling method. Data were collected using questionnaires, and the analysis was done using SPSS version23. Logistic regression was used to determine the factors associated with exclusive breastfeeding, and statistical significance wasdetermined at a 5% significance level.ResultsTwo hundred eighty mothers participated in the study. The mothers' average age was 27.8 (±4.12) years, while the babies were, onaverage aged 7.6(±1.2) months. About 63% of the mothers were married, and 67% had 2 to 5 children. The level of exclusivelybreastfeeding was at 30% (95%CI: 25.2-36.03). Being married/cohabiting (OR=2.877, 95%CI: 1.21-6.90), acquiring up tosecondary/tertiary education level (OR=4.282, 95%CI: 1.78-10.30), is not advised to give their children food/drinks with the first six(OR=0.04; 95%CI (12.94 – 51.19); P<0.001).CONCLUSION AND RECOMMENDATIONThe percentage of exclusive breastfeeding in Somalia is below the level recommended by WHO and National Infant and Young Childfeeding practices (IYCF). Interventions from the Somali government regarding policies, guidelines and protocols are highly needed.
Continuing Somatostatin Does Not Prevent Rebleeding After Variceal Ligation For Acute Variceal Bleeding
Authors: Yasser A. Abdelghani  , Reem Yehia
Published: November 2022

Background: variceal bleeding (VB) is a medical emergency. Endoscopic variceal ligation (EVL) performed quickly is beneficial. Evenafter EVL, somatostatin is still utilized in the VB band for 2–5 days. The advantage of continuing somatostatin after EVL is uncertainsince EVL is the main method for achieving hemostasis.Aim and objectives: to determine if continuing somatostatin after EVL is effective in reducing mortality and rebleeding.Subjects and methods: In this study, 75 patients with variceal bleeding were divided into two treatment groups (TG); TG2 & TG5,which received somatostatin (250 micrograme bolus + a continuous infusion of 500 micrograme/h) for two days and five days,respectively, and one control group (TG0), which received 0.9 percent normal saline and was monitored for six weeks.Result: There were a total of 8 rebleeds; they happened more often in the TG0 (4%) and TG2 (2.6%) and TG5 (4%) groups, albeit notstatistically significantly (P=0.751). The treatment group substantially experienced more adverse drug reactions (ADRs) than the controlgroup (P=0.003). Diarrhoea was the most frequent ADR, followed by hyperglycemia and bradycardia, with 14 patients mentioning twoor more ADR. In comparison to the control group, ADR was considerably greater in the treatment groups. As the days of somatostatinmedication increased, the length of the hospital stay rose considerably (P=0.041).Conclusion: We conclude that in acute VB, there is no justification for continuing somatostatin after EVL since it had no beneficialeffect on preventing rebleeding and, instead, increased the risk of ADR and length of hospital stay.
Analysis of the Genitourinary System Disorders in Adult and Child Population in Osh Region from 2010 to 2019 years
Authors: Maamatova Burul Maamatovna  , Kalmatov Roman Kalmatovich  , Topchubaeva Elida Tairovna  , Metova Zhazgul Bukarbaevna  , Orunbaeva Bibigul Mamatovna  , Askarbekova Guldeste Askarbekovna
Published: November 2022

This article is investigating study of genitourinary system morbidity indicators in the adult population of Osh region for the period 2010-2019. Materials and methods: selection and summary information on the main indicators characterizing the morbidity among adult population in the Osh region with genitourinary system diseases for the period from 2010 to 2019 was based on statistical data. When comparing two data rows based on their mean values, the Student's t-test was used to compare values. Differences were considered as reliable at significance level p<0.05. Research results: When analysing the obtained data, it can be noted that the highest value of genitourinary system total morbidity was recordedin 2017 (46546 people per 100000 population), the lowest in 2019 (31722 people per 100000 population) (p<0.05). A similar trend was observed among women: the maximum value of the general morbidity indicator was revealed in 2017 (33496 per 100 thousand population), the minimum in 2019 (23140 per 100 thousand population). The lowest indicator of this parameter in men is in 2019 (8582 per 100 thousand population). The highest value of the indicator of primary morbidity is in 2011 was 22501 per 100 thousand. The population in 2015 was 22899 per 100000 population, the smallest as 11591 per 100 thousand population in 2019. Kidney and urinary system diseases (N00-N39)-21.05% lead among nosological primary morbidity in the general structure, among them chronic pyelonephritis (N11) has the largest specific weight during the entire observation period.
Effectiveness Of 8 Weeks Of Vestibular Exercises Auditory And Visual Reaction Time In Young Adults
Authors: Basavaraj Muralidhar Tenginkai  , Sai Sailesh Kumar Goothy  , Poonam Basavaraj Tenginkai
Published: November 2022

Background: It was hypothesized that vestibular stimulation causes improvement in auditory and visual reaction time in young adults.Objective: The present study was undertaken to observe the effectiveness of 8 weeks of vestibular exercises on auditory and visual reaction time in young adults.Materials and methods: A total of 40 male and female young adults were part of the study after obtaining informed consent. They were grouped into control and intervention groups by random numbers generated by the software randomizer.org. Reaction time was recorded by the reaction time apparatus. Post-intervention values were recorded after 8 weeks of intervention and compared.Results: There was a significant improvement in the auditory and visual reaction times in young adults who followed by the intervention. Conclusion: The present study results suggest that vestibular exercises have a positive impact on reaction time. The study highlights the need for further detailed studies in this area.
Effectiveness Of Foot Care Practice Tool On Diabetes Control Among Diabetic Patients With Risk For Foot Ulcers In South India
Authors: Rammuanpuii Paihte  , Timsi Jain  , Sharmila.J  , Rajagopalan Vijayaraghavan
Published: November 2022

Introduction: Diabetic foot ulcer (DFU) is very susceptible to infection, which rapidly spreads in the foot and ultimately leads toamputation. Diabetic foot infection (DFI) is a serious threat to public health around the world because it can lead to death. The aim ofthis study was to design a foot care practice tool and evaluate the effectiveness on diabetics in terms of knowledge, skill and hemoglobinA1c.Methods: An experimental pretest - posttest study design was used for this study. A total of 200 diabetics participated in this study inwhich 100 diabetics in the control group and 100 diabetics in the experimental group.Results: The present study findings show that 48.1 % improvement in foot care knowledge in the experimental group and 7.1%improvement in the control group. Experimental group showed 0.46 % reduction in HbA1C level comparing to a 0.05% reduction inHbA1C in the control group.Conclusions: This study showed an increase in the foot care knowledge and skill of diabetics after the intervention and drastic reductionin HbA1C in the experimental group compared to the control group. The study conveys a strong message to diabetes health careproviders about the critical need for foot care awareness programmes among diabetics.
Knee Joint Replacement: A Study Of The Patient Profile In Central India
Authors: Ashwin Chavan  , Suvarn Gupta  , Kunal Saoji  , Vasant Gawande  , Siddharth Jain
Published: November 2022

Total knee arthroplasty (TKA) are increasing worldwide [1]. The rates have almost increased to 60% more in the last decade in theelderly. Total knee replacement or Knee arthroplasty has made a revolution the field of orthopedics as the earlier thought of painfulconditions like osteoarthritis or rheumatoid arthritis could now be solved by replacing the damaged joint with an artificial joint whichdramatically improves the pain of the patient and the person who could barely walk due to pain starts walking again pain free. Whilemost years these joint replacement surgeries were out of reach for common patients, various schemes implemented by the Govt hasmade it possible that even poor needy patients can get the total knee arthroplasty done and can live a better quality of life free of painand suffering.Methodology: This study was a record based observational study conducted retrospectively in the department of Orthopaedics in atertiary care hospital in central India from 1st March 2021 to 28th February 2022.Observation and Results: A total of 40 patients were studied in total. Out of them 22 were males and 18 were females. The mean ageof the patients was 58.2 years. Out of the 40, 15 patients had yellow ration card i.e. belonging to lower socio economic status while 15had saffron ration card and only 10 had white ration card. Majority of the population was Hindu (40%) followed by Muslims (25%),Buddhist (25%) and 10% were Christians, Sikhs and Jains. Majority of the population was educated up to 10th standard while 15%were illiterate. Osteoarthritis was the most common indication for hip joint replacement (70%).Conclusion: Knee joint replacement is being done commonly in the right candidate and helps in alleviating patients from theirsufferings.
Efficacy Of Systemic Or Perineural Dexamethasone As An Adjunct To Ultrasound Guided Supraclavicular Block
Authors: Mohanhariraj Angamuthammal  , Megala R  , Manivannan P  , Sivakumar G  , Parthasarathy S
Published: November 2022

Background: Regional anaesthesia (RA) techniques have traditionally been utilized for surgical anaesthesia and post-operative pain control. Post-operative analgesia from an epidural or a peripheral nerve block can benefit the patients with better recovery and more satisfaction. Innumerable additives have been tried in nerve blocks with variable results. We wished to evaluate the use of addition of dexamethasone with local anaesthetics and compare the efficacy with simultaneous administration of systemic dexamethasone in brachial plexus blocks. Methods: Ninety-seven patients posted for upper limb surgeries were divided randomly into three groups to receive ultrasound guided supraclavicular brachial plexus block with bupivacaine saline combination(A) or dexamethasone bupivacaine combination(B) or a systemic dexamethasone(C) with bupivacaine alone in the plexus site. The onset and duration of sensory and motor blocks were noted.ANOVA, Chi square tests and intent to analyses were done according to the need and a p value of less than 0.05 was considered significant. Results: The variables like mean age, weight, duration of surgery were similar between the groups. The onset and duration of sensory and motor blocks were similar with addition of dexamethasone either in plexus(perineural) or systemic. Onset (A, B, C -17 vs 12 vs 12 in minutes) duration of sensory anaesthesia (414 vs 857 vs 838 minutes) But patients in both the dexamethasone groups showed significant shortening of action in onset and prolonged duration than saline group. (p <0.001), There were no significant side effects.Conclusion: Systemic dexamethasone had a similar effect on the onset and duration of both the sensory and motor actions in supraclavicular brachial plexus blocks as perineural dexamethasone. Dexamethasone usage, both systemic and perineural, reduces cumulative postoperative analgesic usage in the first 24 hours. Either of the two techniques outperformed the control group, which received only normal saline. There were no significant negative side effects.
An In-Vitro Study Comparing The Push Out Bond Strength Of A Fiber Post System Employing Four Different Resin Cements.
Authors: Dr Prateek Singh  , Dr. Niladri Maiti  , Dr. Babacar Touré  , Dr. Anshu Gupta  , Dr. Nadiya Gupta  , Dr. Sruthi.M
Published: November 2022

Background: Debonding is one of the common reasons for failure in fiber-reinforced composite posts, and it tends to occur at the post space-dentin adhesive contact. The goal of this investigation was to evaluate the push-out bond strength of a fiber-reinforced post system by using four distinct types of resin cement.Materials and Methods: This in-vitro research used a decoronation technique on forty mandibular premolars, and endodontic treatment was performed on the roots. After the post space preparation was complete, the root specimens were divided up into four groups of ten each and categorized accordingly. The following are the names of the four resin cement systems that were used to cement fiber-reinforced composite posts: (a) Multilink Speed, (b) Rely X Unicem, (c) Calibra, and (d) Permaflo DC. Three portions of each root were cut to a thickness of three millimeters, and these parts were prepared. The bond strength values were determined by performing a push-out test using a universal testing machine at a crosshead speed of one millimeter per minute (mm/min). After compiling the results, a post-hoc Scheffe test and multivariate analysis of variance (MANOVA) were carried out on the data.Result: The product with the greatest mean push-out bond strength was Rely X Unicem, followed by Multilink Speed and then Permaflo DC. Calibra was found to have the mean push-out bond strength that was the lowest. Using the MANOVA and post-hoc Scheffe tests, we discovered that the push-out bond strength of resin cement varied significantly across the various root canal areas. These variations were statistically significant.Conclusion: The mean push-out bond strength of Rely X Unicem was the greatest, followed by Multilink Speed and Permaflo DC in that order. When compared to Calibra, the mean push-out bond strength was found to be the weakest.
An In Vitro Study Of The Effects Of Final Irrigation Protocols On A New Bioceramic Sealer
Authors: Dr Prateek Singh  , Dr. Rachita Mustilwar  , Dr. Sidhant Pathak  , Dr Harpreet singh Chhabra  , Dr. P. Charulata Sree  , Dr. Arindam  Banik
Published: November 2022

Aim & Objective: The objective of this in vitro research was to assess how final irrigation techniques affected the apical micro leakageof a bioceramic sealer.Materials and Methods: To standardise the canal length, sixty single-rooted mandibular premolar teeth that had been removed were obtained and decoronated. The working length of the root canals was established after accessing them. NiTi rotary files were used to prepare the root canals. Based on the final watering strategy, samples were randomly split into three groups, totaling 20 N.Group1. 5 ml of 17% EDTA for 1min followed by 5ml of 5%NaOCl, 5ml Distilled water. Group2. 5ml of Q MIX 2 in 1, 5ml Distilledwater. Group3. 5ml of 2% CHLORHEXIDINE, 5ml Distilled water. Using a single-cone approach and a novel bioceramic sealant, the canals were obturated. To enable the sealer to fully set, all roots were put in 100% humidity and incubated at 37 oC for 24 hours. After the root surfaces had dried, two coats of nail polish had been applied, with the exception of the 2mm at the tip, which had been submerged in 1% methelyne blue for 72 hours. After that, the samples were longitudinally sectioned, and dye penetration was examined using a stereomicroscope (10xmagnification). Using the Image Pro Express 6 software, the maximum apical dye penetration leakage was determined. One-way ANOVA and Tukey's HSD post hoc analysis were used to statistically analyse the data.Results: Of all the experimental groups, Group 1 had the least percentage of apical leakage. Between each group, there were significant variations in the degree of apical micro leakage (P 0.001).Conclusion: Within the constraints of this investigation, it was shown that when Bioroot RCS was used as the sealer, final irrigation with 17% EDTA followed by 5% sodium hypochlorite demonstrated the least degree of apical leakage.
Evidence Based Review And Analysis On The Impact Of Orthodontic Intervention On Periodontal Clinical Attachment
Authors: Dr. Chetan Chandra  , Dr. Gourav Patil  , Dr.Danish Uz Zama Khan  , Dr. Mahak Gupta  , Dr. Anamika Gupta  , Dr. Khwaja  khijir
Published: November 2022

Background: By the means of this systematic review, we aimed to analyse the correlation present (if any) between orthodontic treatment modalities and their impact on periodontal clinical attachment levels. Methodology: Using the PRISMA framework, a thorough review of research that were listed in the PubMed, Web of Science, and Cochrane library databases was performed which revealed 103 papers, 54 of which were thoroughly evaluated. Exclusion and inclusion criteria were employed to choose studies that were applicable for our review, and finally we shortlisted 10 studies that were found to be suitable for the review. Results: No exact correlation could be drawn between orthodontic intervention and its subsequent impact on clinical attachment loss on the basis of the articles reviewed and thereupon statistical analysis. Conclusion: There is a significant lack of evidence that suggests orthodontic treatment’s impact on periodontal attachment, though it must be mentioned that further investigations in the future might unearth newer observations, and as such, the objective of our review is open to further debate.
A Comparative Study Of Age Estimation Methods In Forensic Odontology
Authors: Dr. Ayushi Sharma  , Dr. Nishath Sayed Abdul  , Dr.Aishwarya Singh  , Dr Hiroj Bagde
Published: November 2022

Aim: The purpose of the research was to assess the Demirjian method's applicability and compare it to Indian methods for estimating dental age in participants enrolled in an Indian dentistry school.Materials and Methods: The research comprised 250 participants, 130 boys, and 120 females, aged 7 to 18 years, who had orthopantomography. The subject's chronological age was reported using their birthdate. Utilizing Demirjian's and Indian formulae, dental age was calculated. The collected data was all placed into a spreadsheet and put through statistical analysis.Results: The research sample's mean chronological age was 12.39 ± 3.32 years, whereas the mean ages determined using Demirjian's approach and the regression formula customized for India were 11.56 ± 3.17 years and 14.20 ± 3.24 years, respectively. Demirjian's technique in this research underestimated dental age in men by 0.84 years and in females by 0.83 years (P 0.05). Males' dental ages were overestimated by 1.72 years and females' dental ages by 1.91 years using Indian-specific regression formulae (P < 0.05).Conclusion: The published regression methods for Demirjian and India are not appropriate for the current research group. Therefore, cubic regression formulae for boys and females in the Indian population were created.
A Sneak peek (1970-2021) Into Phytochemistry and Ethnomedical Properties of Solanum Nigrum Linn (Makoi)
Authors: Kirti Goel  , Md Sohel Ahmed  , Randhir Singh  , Vipin Saini  , Seema Bansal
Published: November 2022

Introduction: Plants have always played a substantial role in the traditional medicine system worldwide. In India and other parts of theworld, Solanum Nigrum Linn. is one of the most promising and reliable sources of medicine in the traditional medicine system. It iswell known for its dynamic therapeutic properties. The concrete objective of selecting this plant is to consolidate its bioactive elementsand possibly medicinal qualities. So that future scientists and researchers may progress novel pharmaceuticals for pre-clinical andclinical trials, which could be launched as new targeted therapeutic options.Method: This review summarized the previous three decades' worth of scientific publications from online databases such as GoogleScholar, PubMed, ScienceDirect, Web of Science, and library books to assemble their possible phytopharmacological and therapeuticpotentials.Results: From the ongoing research database, S. Nigrum possesses a plethora of active phytoconstituents like glycoproteins,polysaccharides, polyphenolic compounds, and glycoalkaloids which are responsible for various pharmacological activities such asantioxidant, anticancer, antitumor, hepatoprotective, antidiabetic, and anti-asthmatic etc.Conclusion: This mystic herb has exhibited numerous ethnomedical properties in humans. Our research findings provide clear evidencethat S. Nigrum could be a potential natural source of several ailments and might be marketed as an alternative to contemporarymedicines. The stem, flower, root, and seed contain numerous dynamic bioactive constituents that are unexplored. Future researchershave an excellent opportunity to investigate them and elucidate their biomedical scientific activities and mechanisms in differentdiseases.
Implementation Of Box Behnken Design To Fabricate The Formulation, Optimization And Dissolution Of Blueberry Nanosuspension
Authors: Geeta Mahlawat  , Tarun Virmani  , Muhammad Arif
Published: November 2022

The present study aims to enhance the bioavailability of Blueberry by formulating it as nanosuspension. Blueberry mainly consists ofanthocyanins which have strong antihyperlipidemic activity but suffers from low bioavailability which causes hindrances in itstherapeutic activity to treat hyperlipidemia. Hence to improve its bioavailability, nanosuspension of blueberry was prepared. BoxBehnken design was applied to predict the effect of independent variables namely concentration of chitosan and concentration oftripolyphosphate (TPP) and stirring speed on two responses namely particle size and entrapment efficiency. The design suggested thata formulation having a particle size of 205.05nm and entrapment efficiency of 76.60 % will be an optimized formulation if it haschitosan, TPP,and stirring speed of 0.5%, 0.05%,and 1050 rpm respectively. The formulation suggested by design was prepared and itwas found that particle size and entrapment efficiency of nanosuspension 198.5 nm and 75.14±0.56 % respectively. In addition, it wasfound to have polydispersity index, refractive index, zeta potential of 0.351, 1.33, 21.08mv respectively.SEM analysis showed thedroplet size under 200nm.When compared towards blueberry nanosuspension with drug extract release it shows the controlled releaseof drug up to 8 hrs which enhances the bioavailability of drug and drug extract suspension showed the maximum release in 2hrs whichshows the immediate release of the drug. As a result, our research shows that nanotechnology might be utilized as an effective approachincreasing the bioavailability of blueberry nanosuspension and this article also focuses on the antihyperlipidemic activity ofanthocyanin.
Compare and evaluate the severity of alveolar bone loss in female patients with and without tobacco smoking in chronic Periodontitis- an observational study
Authors: Dr. Roshni Zama Khan  , Dr. Veena Kalburgi  , Dr Anjali Kothari  , Dr Shivanand Bagewadi  , Swati Hurmade  , Dr Sayli Langote
Published: November 2022

Introduction: The 1996 World Workshop in Periodontics looked at a variety of research and found that smoking was associated withan overall increased risk of severe periodontal disease, with an estimated overall odds ratio of 2.82.5 Previously, researchers had linkedsmokers; higher frequency and severity of periodontal disease to the presence of more plaque and calculus than non-smokers. However,research shows that the effect of smoking on periodontal condition is independent of the plaque index and dental cleanliness of theindividual, thanks to a greater knowledge of the host response. To the best of our knowledge, this is the first study of its kind to beconducted. Scarce research is seen regarding relationship of smoking females with periodontitis. The hypothesis of our study was thatthere is a significant association between tobacco cigarette smoking and periodontitis among female population. As a result, smokingappears to have a direct effect on periodontal tissues. Periodontitis is an inflammatory condition of the teeth’s supporting tissues causedby various microorganism that leads to the gradual deterioration of the periodontal ligament and alveolar bone, resulting in pocketformation, recession, or both . Smoking habits is prevalent in female gender extensively in this part of the country. Hence, this studywas undertaken to analyse the clinical and radiological alterations in smokers and non- smokers female population to further strengthenour knowledge on etiopathogenesis of periodontal disease with effect modified by gender.Materials and Method 60 female patients in the age group of 25 – 50 years, with moderate to severe form of chronic Periodontitis, weredivided into 2 groups- Group A-Female patients with tobacco smoking and Group B -Female patients without tobacco smoking.Results The result vary significantly in both the groups. In female smokers , molars were the gravely affected teeth in both maxillaryand mandibular arches while the canines were the least affected and Palatal surface showed a greater bone loss in both upper and lowerarches.Conclusion: In this study we have concluded that Bone loss higher in smoking population than their non-smoking cohorts. Maxillarymolars had a higher amount of bone loss appreciated radiographically followed by maxillary incisors, premolars and canines. The samefindings were true for mandibular molars. Maxillary palatal and mandibular lingual exhibited greater bone loss scores than buccalsurfaces. We strongly recommend a prospective cohort study of cigarette smoking in females and its relation with periodontal diseasein future research. All the periodontal parameters including gingival index, CAL , Plaque index significantly higher in female smokersas compared to non smokers
Lamotrigine Novel Cocrystals: An Attempt To Enhance Physicochemical Parameters
Authors: Ramu Samineni  , Jithendra Chimakurthy  , Narahari Narayan Palei  , Phani Krishna Yella  , Sabareesh M  , Guru Prasad M
Published: November 2022

Background: Cocrystals are defined as multiple component structures whose components interact through non-covalent interactions.Cocrystals can enhance other essential properties of the APIs.Aim: The current research work focuses on formulating and evaluating novel co-crystals of Lamotrigine anti-epileptic drug (BCS-II)Methods: The Cocrystals of Lamotrigine drug with different cocrystals formers like Saccharin sodium, 4-Hydroxy benzoic acid, andMethyl paraben used with molar ratios (1:1) were prepared by solvent drop method, co-grinding method, and solvent evaporationmethod.Results: The results signify the establishment of intermolecular interaction within the cocrystals. In the novel cocrystals, Lamotriginewas determined to be engaged in the hydrogen bond interaction with the complementary functional groups of Saccharin sodium, 4-Hydroxy benzoic acid, and methyl paraben. Compared with the pure Lamotrigine flow properties for prepared co-crystal by usingsolvent evaporation method crystals are showing excellent flow properties. LTG-SAC CF I, LTG-HBA I, and LTG-MP III showed49.6 folds, 7.4 folds, and 3.36 folds improved solubility respectively. The dissolution test showed that the LTG-SAC CF I, LTG-HBAI, and LTG-MP III cocrystals exhibited a 1.09-fold, 1.08-fold, and 1.07-fold higher dissolution rate than the pure Lamotrigine.Conclusions: LTG-SAC CF I, LTG-HBA I, and LTG-MP III cocrystals showed modification in the chemical environment,intermolecular interactions were established, improved flow properties with enhanced intrinsic solubility and in-vitro dissolution ratethan pure drug.
“Antifungal Susceptibility Pattern of Oropharyngeal Candidiasis in Cancer Patients”
Authors: Amit Kumar Singh  , Dakshina Bisht  , Jitendra Kumar Chaudhary  , Desh Nidhi Singh
Published: November 2022

Introduction: Fungal infections like oral candidiasis is prevalent in cancer patients as their immune systems were compromised.Material and Methods: 377 cancer patients who were clinically diagnosed with oropharyngeal candidiasis were included in the study. Isolation and identification of Candida species was based on standard microbiological procedures. CLSI (2021) recommendations were followed when determining antifungal susceptibility.Results: Among the total 377 cases included, the highest number of instances was reported in those aged 41 to 50 years (30.23%). Candida albicans (21.98%) was the most frequent followed by Candida tropicalis (18.84%), Candida prapsilosis (17.80%). Monomicrobial growth was observed in 77.63% patients whereas polymicrobial growth was observed in 22.36% patients. Candida albicans (24.59%) and Candida tropicalis (20.49%) were the most frequent isolates among patients who underwent chemotherapy while Candida albicans (40%) and Candida Parapsilosis (26.66%) were the most frequent isolates among patients undergoing radiotherapy. Miconazole was found to be more susceptible than Fluconazole, Itraconazole, Clotriconazole among the antifungals.Conclusion: Due to the risk of a systemic infection, it is important to recognise candidiasis as soon as possible for the clinical management of seriously unwell cancer patients. It may also aid the clinician in selecting antifungals for empirical treatment.
Association of KISS1 Gene SNPs (rs12998) With Endocrine Parameters in Iraqi women Polycystic Ovary Syndrome
Authors: Bashar Hassan Abood  , Rayah Sulaiman Baban  , Enas Adnan Abdulrasol
Published: November 2022

background: (PCOS) is among the most common types of gynecological hormonal abnormalities and metabolic problems that have an impact females throughout adolescence, with a prevalence of 6-10%.Hyperandrogenism, unreliable menstrual periods, and polycystic ovaries are the hallmarks of PCOS. The (HPG) axis is controlled by kisspeptins, peptides made by the KISS1 gene.Objectives: This investigation's objective about used to be to analyze the affiliation of kiss1 Gene SNPs (rs 12998 ) with Endocrine Parameters in PCOS .Methodology: A case -control find out about enrolled one hundred sixty members of which eighty female have PCOS and eighty symbolize the manage crew who had-been interestingly healthful. Patients with PCOS had been chosen patients from our health center and the teaching hospital's gynecology and obstetrics department in Tikrit. Assessment of serum ( kisspeptin, estradiol ,LH, FSH and testosterone) used to be performed the use of ELISA approach and the maker company's provided methodology was followed to extract genomic DNA from whole blood. KISS1 Gene SNPs rs12998 T>C gene polymorphisms was once detected by using (T-ARMS-PCR) method.Results: Findings indicate, the frequency of the kiss1 gene rs12998 CT and TT genotypes in PCOS-affected women increased 1.63-fold and 8.88-fold in comparison to the group of healthy women which have odds ratio (OR); 1.63 and 8.88, 95% [CI], 0.667-3.988 and 2.014-39.222; p-value 0.28 & 0.01**), respectively. The levels of Kisspeptin, LH, and testosterone also differ.Conclusions: Our find out about suggests a greater awareness of Kisspeptin serum levels were observed in PCOS as in contrast with healthy as well, the frequency of homozygous allele (CC) used to be greater in patient 15 than in controls 3 whilst the frequency of heterozygous allele (CT) have been now not drastically distinct in PCOS fifty six much less than the controls sixty one The allelic frequency of SNP rs12998 C/T used to be detected extra regularly with significant affiliation in female with PCOS than in
“A comparative study of Nebivolol plus Amlodipine and Atenolol plus Amlodipine on blood pressure and heart rate in patients of essential hypertensive patients”
Authors: Amit Kumar  , Shaktibala Dutta  , Anil Kumar Sharma  , Jyotsna Sharma  , Vaishali Lote  , Lalendra Yadav
Published: November 2022

Objectives: Study was conducted to compare the evaluation of efficacy and safety of Nebivolol plus Amlodipine combination with Atenolol plus Amlodipine combination in hypertensive patients.Materials and Methods: A Prospective Observational study was conducted at tertiary care teaching hospital which included a total 334 patients with essential hypertension. The demographic and baseline data, Blood pressure and Heart rate of the patients were recorded. After baseline investigation patients were randomly divide into 2 groups. All patients were subsequently monitored and reassessed at 4th-week, 8th week and 12th weeks of interval during each follow-up.Results: Nebivolol plus Amlodipine group include a total 169 patients in which 129 patients were males and 40 patients were females with mean age 46.89 ±12.48 years, Atenolol plus Amlodipine group include a total 165 patients in which 111patients were males and 54 patients were females with mean age 48.19±12.14 years. Patients were receiving Nebivolol plus Amlodipine and Atenolol plus Amlodipine showed a significant fall in systolic blood pressure (SBP), Diastolic blood pressure (DBP) and Heart rate at the end of 4th, 8th and 12th weeks of interval as compared to their baseline data.Conclusion: A Study revels that Reduction of blood pressure and Heart rate were similar in both treatment groups (Nebivolol plus Amlodipine and Atenolol plus Amlodipine).(P- value >0.05)
Self administration versus supervised use of Medical Abortion pills: Impact on women’s health
Authors: Neelima Agarwal  , Manisha Gupta  , Alpana Agrawal
Published: November 2022

Background: In India, despite of the fact that abortion facility is available legally under MTP act 1971, women seeking termination of pregnancy often ignore the legal status of abortions and have unsafe abortions. Medical abortion in the first trimester is safe, efficient and approved method of MTP, but should always be taken under the supervision of a registered medical practitioner. The unsupervised use of drug should be stopped as this can endanger life.Objective: To assess the effects of self-administered use of over the counter pill and compare it with the supervised use of mifepristone-misoprostol for medical termination of pregnancy in a tertiary care hospital; and to study its impact on women’s health.Methodology: The study was conducted in the Department of Obstetrics & Gynaecology at a tertiary care hospital of North India over one year period. 322 patients fulfilling the inclusion and exclusion criteria were taken up for the study. Data was compared and analysed in patients with history of self consumption of medical abortion pills versus supervised pills intake.Result: Majority of the patients were young, belonged to the urban area and were Hindu by religion (p<0.0001). Only 66.3% patients in the unsupervised group followed the correct regimen as compared to the supervised group where all the patients followed the correct regimen. The complication rate was 73.1% in unsupervised group as compared to 42.6% in supervised group (p<0.0001). There was significant statistical difference between both groups in respect to success and failure rate with p<0.0001.Conclusion: This study shows urgent need for legislation and restriction of drugs used for medical termination of pregnancy. Drugs should be made available via health care facilities under supervision to reduce maternal mortality and morbidity due to indiscriminate use of these pills.
BIO-INSPIRED ENSEMBLE FEATURE SELECTION (BIEFS) AND ENSEMBLE MULTIPLE DEEP LEARNING (EMDL) CLASSIFIER FOR BREAST CANCER DIAGNOSIS
Authors: R. S. Padma Priya  , P. Senthil Vadivu
Published: November 2022

Breast cancer is a major disease diagnosed in women, affecting 2.1 million women every year, and is the reason for most cancer-related mortality in women, as per the World Health Organization (WHO). For cancer researchers, accurately forecasting the life expectancy of breast cancer patients is a serious challenge. Bio-Inspired Ensemble Feature Selection (BIEFS) algorithm is introduced uses three feature selection methods such as Adaptive Mutation Enhanced Elephant Herding Optimization (AMEHO), Adaptive Mutation Butterfly Optimization Algorithm (AMBOA), and Adaptive Salp Swarm Algorithm (ASSA) and integrates their normalized outputs for getting quantitative ensemble importance. BIEFS algorithm depends upon the aggregation of multiple FS techniques by Pearson Correlation Coefficient (PCC). Ensemble Multiple Deep Learning (EMDL) classifier is introduced which combines several individual models such as AdaBoost-Convolutional Neural Network (A-CNN), Long Short-Term Memory Network (LSTM), and Deep Auto-Encoder (DAE) is introduced to obtain better generalization performance. Then, these three classifiers such as A-CNN, LSTM, and DAE are used for ensemble classification using a Weight Majority Voting (WMV) mechanism. Wisconsin Diagnosis Breast Cancer (WOBC), and Wisconsin Diagnosis Breast Cancer (WDBC) are collected from University of California, Irvine (UCI) repository for experimentation. Evaluation metrics like Precision, Recall, F-measure, Accuracy, and Area Under Curve (AUC) are used to compare the results of proposed system and existing classifiers. All experiments are executed within a simulation environment and conducted in MATrix LABoratory R 2014 a (MATLAB 2014a) tool. The proposed EMDL classifier is showing better performance as compared to the traditional classification models.
Egyptian dentistry students' perspectives on COVID-19 safety measures: Cross-sectional observational research
Authors: Abeer Saad Gawish  , Kholoud Khaled Radwan  , Aishah Alhodhodi  , Iman Mohammed Taha  , Shadia A. Elsayed  , Marwa Mohammed Tawifq
Published: November 2022

Objective: It is important to evaluate dental students' knowledge, attitudes, perception toward COVID-19 infection control guidelines and its impact on their work.Methods: A cross-sectional study using an online-questionnaire included fifteen statements to assess awareness and knowledge about COVID-19 clinical manifestations and infection control practice protocols among dental students at Sinai University, Egypt. The response of participants to each statement was collected using Likert scale.Results: 486 participants completed the questionnaire-based survey. 75.72% of them had knowledge about the disease contagiousness, 85.98% knew about the symptoms of COVID-19, 91.77% recognized the actual incubation period of the disease, and 47.41% could identify those wild mammals like bats are the possible source of COVID-19, while 68.67% were aware of the spread of virus transmission through interpersonal contacts. 432(88.9%) responders were aware of the infection control guidelines, moreover, they know the ways to prevent the spreading of the virus. 423(87%) responders perceived that dentists are at higher risk than other healthcare professionals. 79.38% of participants gained their information about COVID-19 through social media.Conclusion: North Sinai dental students had a correctitude amount of knowledge, with positive awareness about COVID-19. Government must emphasize the role of social media to spread accurate COVID-19 awareness campaigns.