Acute exacerbation predicting poor outcomes in idiopathic interstitial pneumonia and advanced lung cancer patients undergoing cytotoxic chemotherapy
Authors: Miyamoto Atsushi , Michimae Hirofumi , Nakahara Yasuharu , Akagawa Shinobu , Nakagawa Kazuhiko , Minegishi Yuji , Ogura Takashi , Hontsu Shigeto , Date Hiroshi , Takahashi Kazuhisa , Homma Sakae , Kishi Kazuma ,   Investigators Group for Lung Cancer and IIP, Nakahara Y. , Ohta K. , Gemma A. , Nishizaka Y. , Ogura T. , Kimura H. , Nishi K. , Nakamura M. , Yokomura K. , Taniguchi H. , Tomii K. , Shindo J. , Sato K. , Taguchi Y. , Takahashi H. , Takizawa H. , Homma S. , Nakamura S. , Yoshimura K. , Usui K. , Ichikado K. , Bessyo A. , Sugiyama H. , Hasegawa Y. , Nakamura H. , Sagara H. , Ube K. , Nomura F. , Kiura K. , Yoshiike F. , Takahashi K. , Kita T. , Sakai H. , Bando M. , Matsumoto T. , Inoue T. , Kijima T. , Mukae H. , Masuda N. , Matsumoto N. , Sakamaki F. , Kamimura M. , Takise A. , Kishaba T. , Nishioka Y. , Kashiwabara K. , Yamamoto A. , Fujiuchi S. , Shingyoji M. , Hanaoka M. , Tominaga S. , Kadota J. , Kasahara T. , Motegi M. , Harada T. , Ishikawa S. , Suda T. , Tomizawa Y. , Hayashi R. , Shinoda M. , Terada M. , Jin Y. , Shikama Y. , Kikuchi T. , Kido K. , Yokoyama A. , Fuke S. , Nagase H. , Tanaka H. , Hizawa N. , Miyazaki K. , Ikushima S. , Sakai N. , Hoshino T. , Mishima M. , Ohnishi H. , Imai H. , Nagashima S. , Kojima E. , Ohishi S. , Ohe Y. , Iwakami S. , Mineshita M. , Komase Y. , Harada H. , Imokawa S. , Watanabe H. , Ichiki M. , Kuwano K. , Takahashi N. , Chonabayashi N. , Hisada T. , Yoshida M. , Hirata K. , Watanabe K. , Sugino Y. , Yoshioka S. , Tomioka H. , Aoshima M. , Sugimoto Y. , Ichinose M. , Tamaki S. , Tsuchiya M. , Katayama H. , Okochi Y. , Tanaka H. , Ogata K. , Tsuburai T. , Honda I. 
Published: May 2024

Effective treatment for advanced lung cancer and idiopathic interstitial pneumonia (IIP) remains an unmet medical need. The relationship between chemotherapy’s effectiveness in advanced lung cancer and the risk of acute exacerbation of IIP is poorly investigated. There is limited evidence that patients who experience an acute exacerbation of IIPs during cytotoxic chemotherapy have poorer outcomes than those who do not. Among 1004 patients with advanced lung cancer and IIPs enrolled in our published multi-centre retrospective study from 110 Japanese institutions, 708 patients (male: female, 645:63; mean age, 70.4) received first-line chemotherapy. The occurrence of chemotherapy-triggered acute exacerbations of IIPs and overall survival (OS) were analysed. The OS between groups of patients with and without the occurrence of acute exacerbation was compared at four landmark time points (30, 60, 90, and 120 days), starting from the first-line chemotherapy, using the landmark method. The incidence of acute exacerbation in patients who received first-line chemotherapy with small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) was more frequent in NSCLC patients than in SCLC (4.2% vs 12.6%; odds ratio [OR]: 3.316; 95% confidence interval [CI] 1.25–8.8). Median survival time was 9.9 months (95% CI 9.2–10.7). Patients who experienced acute exacerbation had significant worse survival outcomes than those who did not at various time points (30 days, hazard ratio [HR]: 5.191, 95% CI 2.889–9.328; 60 days, HR: 2.351, 95% CI 1.104–5.009; 90 days, HR: 2.416, 95% CI 1.232–4.739; and 120 days, HR: 2.521, 95% CI 1.357–4.681). Acute exacerbation during first-line chemotherapy can predict poor survival.

Trial Registration number: UMIN000018227.