bluuebunny/crossref_metadata_2025 huggingface dataset:
The influence of sustainability communication on perceived product and service sustainability and trust in DMO
Authors: Bašan Lorena
Published: January 2025

In today’s contemporary tourism market, websites have become an essential online communication tool. This study aims to determine the extent and attributes used in sustainability communication through destination management organizations (DMOs) websites to inform, motivate and engage stakeholders in implementing destination sustainability activities. Based on the online sustainability communication checklist (OSC), content analysis was implemented as the research method for evaluating DMO sustainability communication through their official websites. Descriptive and inferential statistics (bivariate correlation and multiple regression analysis) were used in the data analysis. The research shows that DMOs at all levels insufficiently use official websites to communicate destination sustainability issues to stakeholders. The multiple regression analysis results confirm a statistically significant and positive influence of all sustainability attributes within both dimensions on perceived product and service sustainability and a partial effect of sustainability attributes on trust in DMO within both dimensions. All perceived product and service sustainability attributes and attributes of trust in DMO have a positive and significant relationship with overall information on destination sustainability and stakeholder’s overall motivation and engagement in sustainability implementation. Findings in this article fill the research gap related to the relationship of sustainability communication with perceived product and service sustainability and trust in DMO. The practical contribution refers to the guidelines that can be given to DMO managers to achieve more effective sustainability communication with destination stakeholders through the DMO websites.
Driving innovation at the base of the pyramid: The impact of NGOs and the quadruple helix approach
Authors: Meetei Loitongbam Athouba , Mutum Kelvin
Published: January 2025

This study aims to explore the influence of non-government organizations (NGOs) on innovation and value creation at the bottom of the pyramid (BoP). We thoroughly examined numerous case studies. We chose six NGOs in India and collected data through interviews and secondary sources. The research findings indicate that NGOs operating in developing countries have a higher tendency to create sustainable business models that effectively empower communities at the BoP. In addition, these NGOs have the potential to enhance traditional rural clusters in order to promote inclusive growth, generate value at the BoP through innovation and develop the capacity of communities at the BoP. This study adds to the existing body of literature by examining the quadruple helix model in the context of BoP communities, specifically looking at the involvement of NGOs. In addition, we present a conceptual framework for examining the impact of NGOs on innovation and value creation at the BoP within the quadruple helix ecosystem.
A hybrid multi-criteria decision-making (MCDM) approach for R&D strategic alliance partner selection
Authors: Mokhtarzadeh Nima Garousi , Arab Alireza , Sahebi Iman Ghasemian
Published: January 2025

Technological alliances have become a popular strategy to cope with competitive pressures, short product life cycles, high research and development (R&D) costs and entry barriers. Firms gain access to complementary technologies, insulate from environmental uncertainty, increase knowledge base, access new markets and preserve leadership by using strategic alliances. In this regard, this study aims to establish a framework for R&D strategic alliance partner selection by utilizing a hybrid multi-criteria decision-making (MCDM) approach. In this way, at first, related R&D strategic alliance partner selection criteria are collected from existing literature, and then by using the best-worst method (BWM), which is a novel MCDM method, the weights of these criteria are calculated. After that by using the COPRAS method, available partners for R&D strategic alliance, ranked, and the best ones introduced. The calculation procedure for the weighting and evaluation processes are proposed and validated by using an illustrative example of Iran’s aviation industry. The proposed approach also provides a relatively simple and well-suited decision-making tool for this type of strategic decision-making problem.
Discovery of Methylated DNA Biomarkers for Potential Non-Endoscopic Detection of Barrett's Esophagus and Esophageal Adenocarcinoma
Authors: Kalra Andrew , Ma Ke , Cheng Yulan , Tsai Hua-Ling , Wang Hao , Cope Leslie , Yang Yifan , Lunz Daniel , Laun Sarah , Kann Lisa , Jit Simran , Ahmed Yousra , Gheshlaghi Shayan , Tieu Alan H. , Castillo Vincent , Hales Russell , Feliciano Josephine , Lam Vincent , Marrone Kristin , Hui Ken , Ma Michelle , Hughes Robert , Akshintala Venkata , Bull-Henry Kathy , Ha Jinny , Boudadi Karim , Foda Zacharia H. , Battaforano Richard , Khashab Mouen , Shin Eun Ji , Brewer Olaya , Ngamruengphong Saowanee , Ganster Rachel , Jobe Blair A. , Zellenrath Pauline , Spaander Manon , Zaidi Ali H. , Meltzer Stephen J.
Published: January 2025

Background and Aims:

We sought to develop a minimally-invasive, robust, accessible nonendoscopic strategy to diagnose Barrett’s esophagus (BE), esophageal adenocarcinoma (EAC), and its immediate precursor lesion, high-grade dysplasia (HGD) based on methylated DNA biomarkers applied to a retrievable sponge-capsule device in a cohort representative of the BE population (i.e., mostly short-segment, non-dysplastic BE, NDBE).

Methods:

We identified 12 candidate methylation markers to distinguish normal vs. abnormal esophagus. These 12 markers were first assayed in 21-paired matched NDBE-normal esophageal tissues, then assessed in a case-control study of 234 esophageal samples collected using a sponge-capsule device. A classification algorithm was developed using Least Absolute Shrinkage and Selection Operator (LASSO) in a 199-patient training set and tested in an independent 35-patient test set.

Results:

Twelve markers (A1BG, C9orf50, cg00720137, FLI1, GRAMD1B, HOXB13, IRF4, KCNQ3, NTNG1, SPX, TBC1D30, and USP44) were significantly hypermethylated (i.e., all P<0.05) in BE vs. matched normal esophageal biopsies. A discriminatory three-gene LASSO panel (USP44, TBCD1D30, NELL1), adjusted for age and sex, accurately distinguished HGD or EAC from normal control patients in both training (AUC=0.911, 95%CI=0.863-0.959) and test (AUC=0.969, 95%CI=0.911-1.00) sets. In normal vs. NDBE/LGD/HGD/EAC patients, this algorithm exhibited AUCs of 0.862 (95%CI=0.812-0.912) and 0.864 (95%CI=0.745-0.982) in training and test sets, respectively. In normal vs. NDBE patients, the algorithm yielded AUCs of 0.819 (95%CI=0.748-0.889) and 0.776 (95%CI=0.583-0.968) in training and test sets, respectively.

Conclusions:

This discriminatory biomarker panel algorithm exemplifies a practical nonendoscopic strategy to diagnose BE, HGD, and EAC using a minimally-invasive sponge-capsule device coupled with DNA methylation markers.
Covert Breast Cancer Metastasis to the Gastrointestinal Tract: Is Extra Vigilance Needed?
Authors: Wehbe Sarah , Firkins Stephen A. , Sweeney Jacob R. , Moore Halle C.F. , Rouphael Carol
Published: January 2025

Breast cancer (BC) is a common cancer in females. Spread to the gastrointestinal tract is rare. This is a 61-year-old woman with history of T2N0M0 lobular BC treated 5 years earlier. She underwent endoscopic evaluation for new-onset anemia and was found to have multiple gastric ulcers, a normal-appearing duodenum, and subtle colonic nodules. Targeted and random biopsies of abnormal and normal findings, respectively, showed adenocarcinoma with diffuse immunohistochemical staining compatible with her BC history. This highlights the importance of maintaining a high suspicion index in patients with lobular BC and the utility of random biopsies in such cases.
Rare Finding of Rectal Squamous Metaplasia in Inflammatory Bowel Disease
Authors: Noh Sangkyu , Liu Franklin , Cheong Samuel H. , Taleban Sasha
Published: January 2025

Rectal squamous metaplasia in inflammatory bowel disease is rare. We present 2 cases of rectal squamous metaplasia, one in a patient with Crohn's disease and another with ulcerative colitis. Given the risk of malignant transformation, dysplasia surveillance is important particularly in areas of chronic inflammation. Furthermore, human papilloma virus (HPV) is involved in the pathogenesis of anal squamous cell carcinoma (SCC), but no guidelines exist in the United States for HPV prophylaxis against anal SCC in inflammatory bowel disease. HPV vaccination should be considered in high-risk patients younger than 45 years for prevention of anal SCC, including those with rectal squamous metaplasia.
One Soldier’s War and the New Literary War Hero
Authors: Stinson Logan
Published: January 2025

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In the last two decades the major world military powers (the US, the UK/Commonwealth, and Russia) have all been embroiled in long-running asymmetrical conflicts against insurgent or terrorist forces that have proven to be difficult to resolve and increasingly unpopular at home. The fact that these wars are being fought largely by volunteer, contract, or mercenary soldiers has only widened the divide between the military and civilians. In response to this, the literature emerging from these recent conflicts tends to be fragmented, impressionistic, and highly emotional, as veterans try to convey their inner experiences to what they often perceive as an uncaring or hostile audience, while also exploring the experiences of the Other. This article provides a close reading of Arkady Babchenko’s One Soldier’s War, a collection of stories about his two tours of duty in Chechnya, as an early example of this new trend in war literature, and discusses its fragmented structure, its subversion of the clichés of the war genre, and its attempts to set combat veterans apart from the rest of the populace while simultaneously depicting the war and its horrors in vivid detail. We conclude with a brief discussion of the struggle to share the truth and reintegrate back into civilian society that veterans experience, and how this is manifested in literature.
Integrasi Garis dan Sudut dalam Matematika dengan Nilai – Nilai Islam
Authors: Putra Firnanda Pradana , Rifaldi Rifaldi
Published: January 2025

Integrating or connecting mathematics with Islamic values can add to the treasures of knowledge and increase the level of our faith in Allah SWT. Apart from that, it is hoped that the integration of mathematics with Islamic values will form good Muslim personal character. Mathematics is a branch of science that has several characteristics, namely hierarchical or orderly, autonomous and consistent. This is of course closely related to the condition of Islamic values, one example of which is the prayer service which has one of the pillars, namely the pillars of meaning or order. A Muslim who performs prayer is certainly obliged to understand the pillars of prayer, including being orderly, if he intentionally leaves them, the prayer will be invalid. Related to orderliness, namely that it is carried out sequentially and consistently. This research aims to integrate Islamic values with lines and angles in mathematics. This research uses a literature study method with activity steps, namely reading and recording relevant and authentic sources, managing research materials, critically reviewing knowledge, ideas or findings in the literature and formulating specific theoretical and methodological contributions. The research results show that when a Muslim wants to stand perfectly in prayer, he forms an upright position in a straight line or forms a 180 angle0. Other movements in prayer, if observed, will form certain angles which, if added together, will form a full circle with a size of 3600. The results of the next study are that someone who is studying in class or at science councils will be shown to obtain angle measurements based on the level of knowledge they have. The context of degrees in mathematics means the measurement of angles depicted on a flat plane. This is in accordance with the quotation of the verse from the Qur'an, "Allah raises the rank of those who believe and have knowledge several degrees" (Mujadalah: 11).
Clinical and diagnostic features of whooping cough in children in Omsk
Authors: Puzyreva L , Gashina E , Paimanova L , Golovanova N , Schaefer E , Lobova E , Sabaeva N
Published: January 2025

Whooping cough continues to be a pressing morbidity problem in children, and the risk of severe and complicated courses increases with age under one year. The aim of the study was to evaluate the anamnestic, clinical and diagnostic manifestations of whooping cough in children in different age groups.
Materials and methods. A retrospective, selective case study of 114 children with whooping cough who were treated at the children's infectious diseases hospital of the Children's City Clinical Hospital № 3 was conducted for the period from September 2023 to January 2024.
Results. According to our study, predominantly unvaccinated children (78.9%) were hospitalized with a diagnosis of whooping cough. Among the sick children immunized against whooping cough, children over three years of age who received acellular whooping cough vaccine predominated. Clinically, a typical course was observed in all groups. Mostly, inpatient treatment was required for children under one year of age (42.9%). In these patients, the disease was often severe and led to development of complications. Diagnosis of whooping cough was carried out using the bacteriological method, polymerase chain reaction and enzyme-linked immunosorbent assay.
The modern condition of alternative methods of cholera prevention and treatment
Authors: Ivanova I , Filippenko A , Omelchenko N , Tyurina A , Gaevskaya N
Published: January 2025

The incidence of cholera in the world remains at a high level. The existing potential risk of the spread of this infection to countries of different continents indicates the need for alternative integrated approaches to the treatment and prevention of cholera. The review aims to analyze current data and assess the potential of various compounds as alternative therapies and preventives for cholera. Information obtained from Russian and foreign sources over the past decade, including PubMed, Scopus, Web of Science, Google Scholar and RSCI, is used to study the efficiency of various substances and drugs against the causative agent of cholera. The potential of probiotics, bacteriophages and polyclonal and monoclonal specific antibodies is studied with consideration of enteral and parenteral administration.
Cytometric assessment of blood granulocyte damage intensity in vaccinated guinea pigs upon interaction with Yersinia pestis in an ex vivo bacteremia model
Authors: Kravtsov A , Goncharova A , Klyueva S , Bugorkova S
Published: January 2025

Neutrophil granulocytes (NG) play an important role in the mechanisms of immunoallergic reaction and are capable of destroying extracellular pathogens through NETosis. The aim of the work was to evaluate by flow cytometry the intensity of NG damage in the blood of plague-immunized and intact guinea pigs when modeling plague bacteremia ex vivo.
Materials and methods. Guinea pigs (26 individuals) were immunized subcutaneously with the vaccine strain Y. pestis EV NIIEG and three of its isogenic derivatives; the comparison group consisted of intact animals. On the 21st day of immunogenesis, blood was taken from the heart in a volume of 4-5 ml from guinea pigs in the experimental and comparison groups. Bacteremia was modeled ex vivo by adding 108 mc/ml of Y.pestis grown at 37°С (Yp37), 28°С (Yp28) or cultures inactivated by heating at 60°С – DYp28 and DYp37 – to blood samples. For each group, blood samples without added bacteria served as controls. After 4 h of ex vivo incubation, the samples were fixed and disinfected using the BD FACS Lysing solution reagent, and the NG reaction was taken into account by flow cytometry. When assessing the NG reaction, cells were considered damaged if they had lost their initially high degree of granularity in the process of secretory degranulation and cytolysis. The neutrophil damage index (NDI) was calculated as Dk -Do/Dk, where Dk and Do are the relative content of NG with the initial degree of granularity, respectively, in the control and experiment.
Results. Degenerative changes in granulocytes were recorded only in blood samples from pre-immunized animals in response to the ex vivo addition of Yp37 to the blood. It was noted that the NG response in animals immunized with the vaccine strain was 3 times higher than in guinea pigs immunized with isogenic variants of this strain, which were 200 times less effective in protecting guinea pigs from plague.
Conclusion. The results of cytometric assessment of NDI in an ex vivo model of plague bacteremia can be used to characterize the severity of post-vaccination anti-plague immunity.
A person-specific perspective on the dynamics of anxiety in foreign language learning: A dynamic P-technique factor analysis
Authors: Elahi Shirvan Majid , Taherian Tahereh , Kruk Mariusz , Pawlak Mirosław
Published: January 2025

In the field of second and foreign language (L2) anxiety studies, which are predominantly group-based, the role of individual-level inner workings of L2 anxiety has been neglected. Emerging evidence in L2 learning underscores that while aggregating data from a large number of learners reveals general trends, this approach often overlooks the distinct characteristics inherent in each individual’s data. For this reason, specialists have emphasized the necessity of illuminating unique and individualized experiences of L2 anxiety, both in short- and long-term evaluations. The present study aimed to grasp person-specific variation in L2 anxiety in Sara, an adult female L2 learner. In a year-long ecological momentary assessment study design, Sara provided daily replies to an online questionnaire about L2 anxiety. Using the dynamic P-technique, this research explored how Sara’s L2 anxiety ratings on a given day impacted or predicted her rating on the following day and the consistency of her evaluations over time. Results revealed that a four-factor structure best represented her daily L2 anxiety, comprising lack of self-confidence (LSC), fear of negative evaluation (FNE), performance anxiety (PA), and negative attitude toward language learning (NA). It was observed that on days when Sara experienced higher-than-usual LSC and FNE, her return to equilibrium was slower compared to days with heightened PA or NA. Additionally, despite daily fluctuations in the four subfactors, these factors appeared immune to fluctuations in predictor levels and did not immediately affect other subfactors. Moreover, LSC, FNE, PA, and NA exhibited positive feedback loops, where each subfactor could potentially predict another in subsequent states.
“Tears Dry on Their Own”: A Corpus-Assisted Discourse Analysis of Love, Loss, and Self-Harm in the Music of Amy Winehouse
Authors: Yeh Aiden , Keay Kirsten
Published: January 2025

Grounded on the psychology of language and corpus discourse analysis, this article explores the linguistic patterns in Amy Winehouse’s original compositions (2003–2011) and her tendency to commit self-harm. Voyant Tools (Sinclair & Rockwell 2016), a web-based application, was utilised to generate keywords in context, collocates graph, and visualise word trends across the corpus; sentiment analysis was also conducted to determine if the emotional tone of the message (text) is positive, neutral, or negative sentiment. The findings showed an upward trend in frequencies of keywords in negative contexts; lexicogrammatical phrases conveyed self-deprecating attitude (I’m nothing, I’m no good) and self-destructive intentions (dying, hurt, and losing), and the impact of male figures in her life associating the word man with war and fighting. Changes in syntax structures revealed contextual clues of low self-esteem, negative emotions, and loneliness. Self-disclosure of pain was associated with tears, and her response to infidelity alluded to the toxic relationships that triggered her self-destructive behaviour. The overall text expressed negative sentiment of 0.70. This article argues that the lexical choices and semantic shifts are language devices Winehouse used to express her views on love and loss, awareness of her thoughts and feelings, sense of agency to (re-)assess the men around her, and her identity as a rebellious and headstrong woman who chose her own path to love which eventually had been detrimental.
Tunable structural colors based on grayscale lithography and conformal coating of VO2
Authors: Zhang Xiaochen , Sun Haozhe , Li Yuan , Hao Jianhua , Liang Qinghua , Zhang Yongyue , Wang Yang , Li Xiaowei , Zhang Xinping , Ma He , Li Jiafang
Published: January 2025

Structural colors generated by optical micro-/nanostructures offer a notable advantage over traditional chemical pigments, including higher purity, greater brightness, resistance to fading, and enhanced environmental friendliness. However, achieving dynamically switchable color displays with high performances and without resorting to complex nanofabrication methods remain a challenge. Here, we present a simple method using grayscale lithography and conformal coating to create Salisbury screen (SS) cavities with variable resonant wavelengths, enabling the formation of tunable colorful patterns. The dynamic color display is achieved through the phase change of vanadium dioxide (VO2) nanostructures under electrothermal effects. At a low actuation voltage of 1.4 V, high performances of color switching such as high sensitivity, fast speed, high repeatability, and wide-view angle are achieved. The tunable structural colors, featuring a simple preparation process and high-speed switching, represent a promising alternative for applications such as thermal sensors, security information encryption, and dynamic full-color displays.
Exercise Strategies for Parkinson Disease Management
Authors: Ingoglia Spencer , Graves Barbara Sue
Published: January 2025

Parkinson disease (PD) is a progressive and chronic neurodegenerative disorder that compromises both motor and nonmotor functions, ultimately leading to a decline in functional capacity and quality of life. Although the etiology of PD is multifaceted, exercise has shown promising effects in managing PD symptoms and enhancing patient well-being. Although aerobic and resistance exercise demonstrate benefits within this specific population, the exact application of these modalities varies and often differs depending on disease progression and the individual. Although individuals diagnosed with PD are encouraged to exercise, there is still a lack of information pertaining to how to successfully structure physical activity into their daily routine. There are also distinct barriers and motivators impacting their decision to engage in regular exercise. This manuscript offers practical recommendations and personalized exercise guidelines for exercise professionals, empowering them to optimize PD management through targeted exercise interventions. In addition, it offers current information on promoting exercise among patients with PD, specifically to enhance their functional outcomes.
Disagreement and forms of politeness in Moroccan media debate: An interactional approach
Authors: Azouzi Hassan
Published: January 2025

This study aims explores the concept of disagreement in Moroccan media debates during the COVID-19 pandemic. It aims to analyse how disagreement is expressed and the forms it takes in the context of confrontational televised debates. Drawing on the framework of ethnomethodological conversational analysis, disagreement is viewed as a reactive act that is conditionally dependent on the speaker‘s initiating act. Recognising the potential risks of their respective acts, participants in these verbal interactions employ softeners and/or emphatics to mitigate or intensify their responses, striving to avoid outright rudeness when expressing disagreemnt. The analysis is based on a substantial corpus of transcribed and aligned speech, enabling the identification of key elements that shape responses in this context.
Nabataean mythology (Pharaoh’s treasury)
Authors: Haroun Hiba Farooq
Published: January 2025

The rock facades represent the nature of the Nabataean civilization, as they combined elements from all the civilizations of the ancient Near East, including Assyrian, Egyptian, Syrian, Greek, and Roman, in a distinctive and unique Nabataean mold.
Los conceptos de autoridad, razón y uso en Nebrija: de las «Introductiones latinae» a la «Gramática de la lengua castellana»
Authors: Harto-Trujillo María-Luisa
Published: January 2025

Nebrija fue un pionero tanto en la gramática latina como en la castellana, ya que, en el primer caso, sus Introductiones latinae suponen el primer tratado plenamente renacentista escrito en España y, en el segundo, su Gramática de la lengua castellana constituye la primera codificación gramatical de esta lengua. En ambos tratados parte de los presupuestos de la gramática latina de la Antigüedad y de sus pilares de auctoritas, ratio y usus. Sin embargo, la distinta situación del latín y del castellano en el Renacimiento le llevará a establecer cambios en la admisión de esos pilares, pues, por ejemplo, no le será posible mantener la misma consideración para la autoridad, literaria y doctrinal, en el caso del latín y el del castellano.
Un análisis de las construcciones con se y agente expreso en el español estándar escrito
Authors: Herrera Javiera , Olate Aldo
Published: January 2025

Esta investigación busca caracterizar los tipos de diátesis que presentan las construcciones con se + complemento agente encabezado por la locución por parte de en el español estándar escrito. Se trata de un estudio exploratorio que adopta el enfoque sintácticamente orientado de Kulikov (2011) para describir los distintos tipos de pasivas que componen las diátesis de democión del sujeto en español. Los datos provienen de 500 ejemplos de los corpus CREA y CORPES, analizados con una metodología cualitativa de corte descriptivo-gramatical. Los resultados muestran que, si bien las construcciones con se no paradigmático han sido consideradas semánticamente impersonales, a menudo presentan un agente expreso, cuya referencia puede ser incluso un individuo particular
De locuciones verbales a marcadores discursivos alertadores: estudio semánticopragmático de «vamos a ver» y «veamos a ver» y sus traducciones al francés
Authors: Gómez-Jordana-Ferrary Sonia
Published: January 2025

El objetivo de nuestro artículo es aportar un análisis semántico-pragmático de dos marcadores españoles formados con el infinitivo del verbo ver –veamos a ver y vamos a ver–. Gracias al estudio semántico-pragmático de veamos a ver y de vamos a ver en diacronía –desde el siglo XV hasta el siglo XXI– nos acercaremos al sentido de lo que hoy en día se ha convertido en dos marcadores discursivos que sirven para detener la argumentación del interlocutor o del propio locutor. El estudio de ejemplos en contexto y las propiedades atribuidas a las dos locuciones permiten distinguir valores precisos de vamos a ver y de veamos a ver. Dicho estudio semántico-pragmático será puesto en contraste con un estudio previo sobre el marcador francés voyons voir, comprobando si este podría corresponder a la traducción de los marcadores españoles.
López Grigera, Luisa, intr., ed. y notas. La vida de Lazarillo de Tormes y de sus fortunas y adversidades. Madrid: Arco Libros, 2024. 163 pp. (ISBN: 978-84-7133-899-0)
Authors: Plata-Parga Fernando
Published: January 2025

Book Review
Estudio contrastivo de «a ver», «à voir», «avoi» y otros en español y francés (siglos XII-XVI)
Authors: Saiz-Sánchez Marta
Published: January 2025

Este trabajo describe la evolución de la locución a ver p entre los siglos XII y XVI. Para ello se estudian desde un punto de vista morfosintáctico y semántico las primeras etapas de la gramaticalización de la estructura, que no conoce usos independientes –no introducidos por un verbo– hasta mediados del siglo XVI. El estudio permite apartar la hipótesis generalmente admitida de que el marcador a ver del español contemporáneo proviene de vamos a ver. Se comprueba también que las estructuras de tipo a ver si p tienen un funcionamiento similar al de a ver p, aunque su empleo independiente se atestigua antes, a principios del XV. Por último, se compara el empleo de a ver (p) (locución y marcador) con el de los marcadores à voir y voyons voir, del francés contemporáneo, y con el del marcador avoi, del francés medieval, todos ellos formados con el verbo voir.
A novel analytical strategy for rapid detection of antibiotic dregs adulteration in feed protein materials by headspace gas chromatography–ion mobility spectrometry
Authors: Li Shouxue , Feng Yuchao , Zhang Yusho , Fan Xia
Published: January 2025

The recognized shortage of feed protein materials (FPM), together with their high prices, has almost inevitably led to economically motivated adulteration. In this study, a rapid and accurate headspace gas chromatography–ion mobility spectrometry (HS-GC-IMS) method was applied to detect soybean meal (SM) and cottonseed meal (CM) adulteration with oxytetracycline dregs (OD). A total of 98 volatile compounds were detected in the 14 samples (5 SM, 5 CM, and 4 OD). FPMs and adulterated FPMs in different proportions (0.1, 0.5, 1, and 5%, w/w) were clas-sified based on their volatile compounds using principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). The OPLS-DA model could identify SM-adulterated samples with an OD content of 0.5–5% and CM-adulterated samples with an OD content of 1–5%. More importantly, 18 volatile com-pounds (ether and heterocycle [1 each], acids and terpenes [2 each], and ketones, alcohols, aldehydes, and esters [3 each]) were proposed as volatile markers for OD authentication from FPMs. These results confirmed the potential of HS-GC-IMS to evaluate volatiles in FPMs and are meaningful for FPMs quality. The environmental factors and sample differences will be investigated in future studies to improve the robustness and reliability of HS-GC-IMS.
Investigation of the rheological properties of persimmon puree by using response surface methodology
Authors: Mazlum Sevim Gürdaş , Lodos Dilon
Published: January 2025

In this study, response surface methodology (RSM) was used to determine the effects of pH, concentration, and temperature on the rheological properties of persimmon puree. The combined effects of temperature (25, 50, and 75°C), concentration (15%, 17.5%, 20%), and pH (4.0, 5.5, 7.0) on the rheological properties of persimmon puree were investigated by the Box–Behnken design at a shear rate of 8.4–28 s−1. Based on the results of this study, the puree exhibited non-Newtonian (n<1) and pseudoplastic behavior within the investigated operating parameters. A hysteresis loop was formed, defined as the area enclosed by the forward and backward curves. The backward curves exhibited anti-thixotropic behavior, showing higher shear stress than the forward curves. The flow behavior of persimmon puree was described by the Herschel-Bulkley model (R2≥0.99). The consistency coefficient and yield stress decreased with increasing temperature and increased with increasing concentration. A limited increase in the consistency coefficient and yield stress was observed as the pH increased. The flow behavior index increased with increasing temperature but decreased with increasing concentration. The flow behavior index decreased with increasing concentration and increased with increasing temperature. These results can contribute to food processing industries in producing persimmon puree and may assist in the development of processing machinery for the commercial manufacture of persimmon puree.
Animal Death: Why are Our Pets Worthy of Burial?
Authors:   Ural Federal University, Makakenko Y. A.
Published: January 2025

The article presents a philosophical analysis of the problem of animals’ death and their status in human society. An attempt is made to find a variant of the possibility of recognising animals as “mortal” in a specifically animal sense, without claiming an exclusively human right to be mortal. The article considers the concept of “mutual inclusion” between the human and the animal, which involves redefining the fundamental concepts of “life” and “death” in their possible involvement with both the human and the animal. The concepts of biopolitics, thanatopolitics and necropolitics, which involve the management of human life and death, in their possibility to include the animal, are examined, and the specific meaning of the animal included in the context of the human, which in this sense is given greater definition, is asserted.
Molel of a Video Data Transmission System with Technical Ground Objects of Low Mobility
Authors:   BonchBruevich Saint Petersburg State University of Telecommunications, Prasolov A. A. , Fedorov A. S. ,   BonchBruevich Saint Petersburg State University of Telecommunications
Published: January 2025

Nowadays, technical objects of various degrees of mobility can be used in a wide range of tasks both civil and military purposes. The operation of such objects is impossible without the use of reliable video information and control transmission channels. However, the requirements to such communication channels are significantly aggravated by different operating conditions of these systems. Currently available solutions that allow the transmission of video stream from the camera of unmanned aerial vehicles (UAVs), as a rule, cannot provide the same quality of communication for control of ground technical objects of small mobility of various purposes for their control. The purpose of this study is to analyze the technologies of video information transmission and evaluate the effectiveness of their application in communication channels with technical objects of different degrees of mobility. The simulation model of the receiver and transmitter, carrying out signal processing in the main frequency band is developed, the influence of the parameters of codecs with low density Parity check (LDPS) and Bowes — Chowdhury — Hockingham (BCH) on the quality of video information reception is investigated. The conducted research allows to determine the parameters of codecs that provide the best quality of video information signal reception in different signal-to-noise ratios. The author evaluates the impact of multipath propagation of radio waves, what allows the creation of the model of the receiver that provides video information transmission to ground technical objects with a small degree of mobility.
Construction of algorithms of actions using schemes when solving problems of finding the probability of a random event using combinatorics
Authors: Bredihina Olga , Golovin Artеm , Kulishova Svetlana
Published: January 2025

The article identifies potential problem areas in the field of probability theory and combinatorics, proposes action algorithms with the active use of step-by-step instructions and diagrams. The study determines the need to study examples with visualization of the structure of the choice of formulas for calculating the desired parameters. The ability to identify typical errors in working with data, rank factors by the degree of influence on the economic process, select an action algorithm are formed in the process of solving probability theory problems. It is determined that errors in solving probability problems can be eliminated by systematizing the apparatus of combinatorics. It is noted that the construction of action schemes helps to identify similarities and differences in the choice of combinatorics formulas for calculating the probability of a random event. This process is the basis for developing the ability to find commonalities and differences in economic processes. In the course of studying the process of constructing action algorithms using schemes for finding the probability of a random event using combinatorics, a set of tasks was developed to help find the probability of a random event. The action algorithms proposed in the study are aimed at overcoming standard errors that arise when solving probability problems. The use of diagrams, drawings, visual images, visualization of action algorithms, comparative analysis of examples allows more effective solution of problems of finding probabilities of a random event using combinatorics. Forecasting economic processes using the apparatus of combinatorics will allow influencing their course, controlling, limiting the scope of randomness, and the ability to find the optimal scheme of actions will ensure rational decision-making in the field of economics.
Efficient management of material flows in retail chains
Authors: Stupnikova Elena
Published: January 2025

In the modern economy, retail chains play a key role in the delivery of goods from the manufacturer to the end consumer. Efficient management of material flows in these networks is becoming a decisive factor in business success, affecting the speed of turnover of goods, reducing costs and increasing customer satisfaction. The purpose of this study is to develop recommendations for improving the efficiency of material flow management in retail chains based on the analysis of existing methods and approaches, as well as determining the optimal ways of their implementation in the conditions of a specific retail chain. The efficiency of logistics activities is a system of complex indicators reflecting the quality of the functioning of the logistics system at a given level of total logistics costs. The article considers various approaches to defining and assessing the efficiency of logistics, including traditional and modern methods of analyzing logistics costs. The main attention is paid to key performance indicators (KPI), such as total logistics costs, quality of logistics service, duration of logistics cycles, productivity and return on investment in logistics infrastructure. The article also discusses methods for optimizing logistics costs, including benchmarking, cost analysis, and functional cost analysis. It provides an analysis of foreign and domestic practices, such as the SCOR system, which includes 13 indicators for five optimized functions. The article emphasizes the importance of a balanced approach to managing the logistics system, which includes the proper allocation of resources and the establishment of an economic balance between the quality of service and the level of costs, which allows logistics managers to make informed decisions to improve the efficiency and competitiveness of logistics activities.
Modern issues of food industry economics
Authors: Korneva Galina , Makhinenko Anton
Published: January 2025

The study devoted to the specific features of the economy of food industry enterprises reveals unique aspects that affect their financial activities. The food industry, like other industries, is characterized by specific features that determine its economic dynamics. One of the key features is high raw material dependence, which requires enterprises to constantly provide high-quality raw materials. This leads to an increase in purchasing costs and an increase in the need for working capital, which, in turn, affects the financial stability of companies. Competition in the food industry is quite intense, which encourages enterprises to optimize costs and improve product quality. To achieve a competitive advantage, companies introduce new technologies, which require additional investment, but in the long term can reduce the cost of production. Seasonality of production and dependence on the trade and distribution network also play a significant role. Since products are often perishable, enterprises are forced to develop their own trade and transport networks, which increases investment costs, but allows for more efficient logistics management and reduces costs. Financial management in the food industry should take into account the need for systematic sanitary control, which increases costs, but improves product quality and demand for it. In addition, training and retraining of personnel to work on complex technological equipment also requires significant resources, but in the long term contributes to increased productivity and product quality. Thus, financial management in the food industry requires taking into account many factors, including raw material dependence, competition, seasonality and the need for infrastructure development. Effective management of these aspects can lead to lower costs and increased sales volumes, which is a key success factor in this industry.
A percepção da violência por pessoas transvestigêneres no Brasil e suas implicações na atenção primária à saúde
Authors: Mello Mônica Machado Cunha e , Moretti-Pires Rodrigo Otávio , Signorelli Marcos Claudio
Published: January 2025

RESUMO Objetivo O estudo tem como objetivo descrever a violência percebida por pessoas transvestigêneres no Brasil, articulando-a com a atenção primária. Métodos Catorze pessoas transvestigêneres no Brasil foram ouvidas por meio de 2 grupos focais e 8 entrevistas, realizadas entre dezembro de 2021 e abril de 2022. A análise dos dados utilizou uma abordagem fenomenológica-hermenêutica. Resultados As falas foram agrupadas nos seguintes temas: “o caráter não intencional da violência”, “a violência nos serviços de saúde” e “a família enquanto produtora de violência”. Essas categorias evidenciam que o fenômeno da violência vai além de atos intencionais direcionados a uma pessoa, conforme originalmente pensado pela Organização Mundial da Saúde. Conclusão A população transvestigênere experiencia violências intencionais e não intencionais que afetam sua integridade física e emocional. A atenção primária à saúde pode se configurar como uma aliada no enfrentamento dessas violências se garantir a integralidade do cuidado.
Molecular Dynamics of Adenomatous Polyposis Coli (APC) Protein and Its Inhibitors: A Special Insight to Colorectal Cancer
Authors: Kumari Rina , Ghava Dilip , Rathod Rajeshwari , Panda Amrita Kumari , Kumar Sunil , Behera Santosh Kumar
Published: January 2025

Colorectal cancer (CRC) initiates in colon or rectum is named as colon or rectal cancer, based on the site of inception. Various genetic alterations responsible for CRC include several signaling pathways. The Wingless/Wnt signaling pathway is the vital pathway which involved in the cancer pathogenesis. The hallmark of human CRC is adenomatous polyposis coli (APC), a negative regulator of the Wnt pathway. Mutations in the APC gene is a critical event in the development of human CRC which may lead to overexpression and stabilization of β-catenin that enters into the nucleus and helps in cancer cell proliferation. Significant obstacles to the therapeutic intervention of the Wnt signaling system still exist, despite promising approaches for the development of anti-cancer medicines targeting this route. The advent of computational techniques for cancer diagnosis, prognosis, and drug development has spurred the researchers to explore CRC at an early stage. This report had unzipped the importance of APC in Wnt signaling pathway associated with current advances and challenges in drug discovery for CRC. A combinatorial computational approach identified the potential anti-cancerous drug among XL888, 5-bromouracil, 5-fluorouracil, and Ganetespib against APC
which is often treated as gatekeeper of CRC. This in silico investigation revealed Ganetespib as a potential anti-cancerous drug against APC for CRC therapeutics, which will be an alternative to chemotherapy. In vitro and in vivo studies are needed further to confirm the efficiency and evaluate potency of Ganetespib against the target.
An adaptive reinforcement learner of spatial interaction based on taxi trajectory data
Authors: Sun Chao , Lu Jian
Published: January 2025

This paper introduces a novel approach for analysing spatial interaction characteristics and land use using taxi trajectory data and urban geographic data. We propose an adaptive reinforcement learning model, based on nonlinear theory, to improve the accuracy and adaptability of spatial interaction predictions. By dividing the urban area into smaller units, we construct a spatial interaction matrix that captures push-pull force characteristics and distance features between origins and destinations. The innovative aspect of our model lies in its ability to integrate multiple weak learners to form a strong learner, which significantly outperforms traditional gravity theory-based models in terms of prediction performance (higher R, lower MAE, and RMSE). Our findings reveal the importance of adjacent flows in predicting spatial interaction patterns and show that travel distance of public transportation is the most significant factor in describing the difficulty of completing spatial interactions. The relative importance of push force from origins is the highest, followed by pull force from destinations and adjacent flows. The results of this study provide valuable insights for traffic and urban planning.
Improving research productivity of bottom-level academics through knowledge acquisition and sharing behaviours
Authors: Adegbaye Sarah
Published: January 2025

University rankings are heavily influenced by the research productivity of their academic staff, making it a strategic resource for enhancing their reputation and social impact. For bottom-level academics, publishing research in reputable journals is crucial for their academic and professional growth. The quality of their research output largely depends on acquiring knowledge from quality sources and sharing knowledge with colleagues both within and outside their universities. Unfortunately, research that primarily focuses on the research productivity of bottom-level academics and the factors that contribute to it has been hitherto ignored. This study investigates the relationship between knowledge acquisition, knowledge sharing, and research productivity among bottom-level academics in selected universities in Ogun State, Nigeria. A correlational survey research design was employed. The population comprised 645 bottom-level academics from three universities in Ogun state. A sample size of 215 was obtained, and 178 properly filled questionnaires were returned. Descriptive statistics, correlation, and multiple regression analysis were used for data analysis. The findings revealed high levels of knowledge acquisition and knowledge sharing among the respondents. However, the overall mean level of research productivity was low, despite a high level of publications in learned journals. Correlation analysis results indicated a significant and positive relationship between knowledge acquisition and research productivity, and between knowledge sharing and research productivity. Multiple regression analysis showed that knowledge acquisition and knowledge sharing had a combined effect on the research productivity of the respondents. The study concludes that knowledge acquisition and sharing significantly influence the research productivity of bottom-level academics in Ogun-State, Nigeria. Recommendations are presented based on these findings.