bluuebunny/crossref_metadata_2025 huggingface dataset:
Ability of qSOFA1-lactate to predict 30-day mortality in patients seen for infection in the Emergency Department
Authors: Julián-Jiménez Agustín , Rubio-Díaz Rafael , González del Castillo Juan , García-Lamberechts Eric Jorge , Huarte Sanz Itziar , Navarro Bustos Carmen , Candel Francisco Javier , de Santos Pedro Ángel , Alonso Avilés Raúl
Published: May 2023

Objectives. To evaluate lactate and the Quick Sepsis-Related Organ Failure Assessment (qSOFA) and compare their ability to predict 30-day mortality in patients treated for infection in emergency departments (ED). Methods. Prospective multicenter observational cohort study. We enrolled a convenience sample of patients aged 18 years or older attended in 71 Spanish ED from October 1, 2019, to March 31, 2020. Each model’s predictive power was analyzed with the area under the receiver operating characteristic curve (AUC), and its values of sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative (NPV). Results. A total of 4439 patients with a mean (SD) age of 18 years were studied; 2648 (59.7%) were men and 459 (10.3%) died within 30 days. For 30-day mortality, the AUC-COR obtained with the qSOFA = 1 model plus 2 mmol/l lactate was 0.66 (95% CI, 0.63-0.69) with Se: 68%, Es: 70% and NPV:92%, while qSOFA = 1 obtained AUC-COR of 0.52 (95% CI, 0.49-0.55) with a Se:42%, Es:64% and NPV:90%. Conclusions. To predict 30-day mortality in patients presenting to the ED due to an episode of infection, the qSOFA =1 + lactate≥2 mmol/L model significantly improves the predictive power achieved individually by qSOFA1 and becomes very similar to qSOFA≥2.
High macrolides and fluoroquinolones resistance rate in Mycoplasma genitalium in southern Tenerife
Authors: Mateo León Cristian , García Martínez de Artola Diego , Pino-Calm Berta
Published: May 2023

Introduction. Mycoplasma genitalium (MG) is a recognized sexually transmitted pathogen. Increasing resistance to main lines of treatment (macrolides and quinolones) justifies a genetic study of mutations to improve cure rates. Material and methods. A total of 8,508 samples from April 2018 to July 2022 were processed using AllplexTM STI Essential Assay. In MG positive cases 23S rRNA V domain, gyrA and parC genes were studied. Mutations detected were checked to assess their clinical significance and medical records were reviewed to obtain demographic and treatment information. Results. Resistance study was performed on 92 samples (65 men and 27 women). In relation to the genotypic study, 28 patients presented mutations to macrolides (30.43%). Most common was A2059G (18.48%). For quinolones, 5 patients (5.43%) had clinically relevant mutations in parC gene. Of note was a patient with G295 mutation in gyrA associated with G248T in parC. Thirty subjects underwent a test of cure (TOC). Azithromycin was the most common empirical regimen and moxifloxacin the main alternative. Conclusions. High rate of resistance in our environment evidences the need for targeted therapy by genotypic study of macrolide resistance, supported by the detection of mutations in parC and gyrA to predict quinolones susceptibility and the use of TOC to evaluate treatment response
Metaphorization of the Trial Using War Terminology in the American and Canadian National Variants of Judicial Discourse: A Comparative Analysis
Authors:   Peoples’ Friendship University of Russia, Dmitrieva Elena A.
Published: May 2023

Cognitive linguistic research into conceptual metaphors is the focus of attention of many scientists. These studies proceed from the postulate of cognitive linguistics which states that the world around us is categorized and structured according to certain cognitive models. These models are often based on the mapping of properties and elements of one concept onto the domain of another concept by virtue of similarity. Thus, conceptual metaphors are created, which are linguistic representations of the cognitive processes of human mind. According to G. Lakoff and M. Johnson’s definition, the metaphorical model “argument is war” is a linguistic manifestation of such cognitive associations. This article presents the results of the study that aimed to determine the extent to which the metaphorical model “trial is war” can be applied to the American and Canadian national variants of judicial discourse, as well as to identify key elements underlying the metaphorical mapping of the concept of war onto the concept of trial. In addition, a comparative quantitative analysis was performed to determine which national variant of judicial discourse contains more metaphors based on the “trial is war” model. The following sources served as the material for the study: judgements of the courts of the United States and Canada, transcripts of the countries’ highest judicial bodies, as well as articles by American and Canadian experts on law and legal proceedings. In order to conduct the quantitative and qualitative analysis, the material was arranged in two monolingual corpora, which were processed using the AntConc software.
The Normative Nature of Self-Identification
Authors:   Saratov State Law Academy, Erokhin Vladimir S.
Published: May 2023

The relevance of studying the problem of self-dentification is associated with the development of society’s man-made environment, computer technologies and means of communication. The development of cyber and virtual space has gained significance and, as a result, the established stereotypes of relating oneself to the models have been changing. In addition, globalization changes in modern society, which determine the possibility of unification of norms and universalization of the values of human existence, are viewed as important. On this basis, it seems necessary to identify other, modern ways to establish personal identity. It appears relevant to study this process from the position of normativity, but not just from the point of view of whether a person has properties that define his/her self. The search for normative bases for forms and practices of self-identification seems problematic. It is important to find criteria and principles of acceptability of establishing personal identity. This paper aimed to determine the normative nature of self-identification. As research methods, the author used the logical method, which allows to analyse the concepts of social normativity and self-identification in detail, as well as the critical method, which makes it possible to relate these concepts to each other. As a result, the normative nature of self-identification is manifested in a set of ascriptive and descriptive requirements for creating personal identity. The unity of such norms is interpreted by the author as a criterion for the acceptability and permissibility of forms and practices of self-identification, which makes it possible to influence the ways of social interaction and, as a consequence, regulation of social ties and relations. Such norms are subject to the evolutionary principle implying a reduction in the number of coercive norms and expansion of the scope of descriptive norms. The various practices of selfidentification are implemented based on its normative nature. Using the example of gender-related practices of self-identification, the author demonstrates the acceptability and effectiveness of the ideas proposed by him.
Training Command Personnel for the Merchant Marine in the Second Half of the 19th Century (Based on the Materials from the Arkhangelsk Province)
Authors:   Northern (Arctic) Federal University named after M.V. Lomonosov, Khromtsova Tat’yana V.
Published: May 2023

The article dwells on the establishment and activities of maritime educational institutions in the Arkhangelsk Province that trained personnel for the merchant fleet. In the mid-19th century, Russia had no system in place for the professional training of navigators for the merchant marine. They were trained in six navigation schools, which was not enough for the entire country. Therefore, the government approved a number of documents that laid the foundation for opening a large number of maritime classes throughout Russia and organizing the work of state examining boards that administered exams for navigational ranks. Due to the favourable location of the Arkhangelsk Province and the interest of the central and local authorities in training navigators for merchant shipping, a number of navigation schools in the region that trained skilled personnel for northern seafaring were opened. The paper examines the process of implementing government initiatives, taking the work of skipper courses and maritime classes in the province as an example. Considerable attention is given to the legislation concerning maritime educational institutions; documents regulating their activities are analysed. Further, the article shows the process of establishing navigation schools, their financing, daily activities, and organization of the educational process. Challenges facing maritime classes are also expanded on. The problems typical of the majority of maritime educational institutions in the country indicated that maritime education required close attention from the authorities and further serious improvement. It should be noted that, in spite of all the difficulties, a considerable number of command personnel for the northern fleet were trained in the maritime educational institutions of the Arkhangelsk Province.
Ukraine, Russia, the European Union and the USA: Reflections on the Lessons of History and Modern Geopolitics
Authors:   Northern (Arctic) Federal University named after M.V. Lomonosov, Goldin Vladislav I.
Published: May 2023

Review of the book: Galin V.Yu. Who Sold Out Ukraine. The Political Economy of Ukrainian Independence. Moscow, 2022. 256 p. (in Russ.). This article presents a review of the book that dwells on the complicated problems of the deep crisis in Ukraine and around this country, which has become global. The book considers the origins of and reasons for this crisis and its significance for contemporary geopolitics. It analyses the economic and sociopolitical processes in Ukraine over the last decades as well as characterizes the historical milestones of its relations with Russia and the present situation. The author of the book demonstrates the role of the United States and countries of the European Union in aggravating the current confrontation, as well as their interests in Ukraine and reasons for supporting the Ukrainian regime and assisting in military operations. In addition, the book emphasizes the danger of further escalation of tension and military actions in Ukraine for the human civilization.
Awarding Law Enforcement Officers in the Pre-War Period (1933–1941)
Authors:   Ural Federal University named after the first President of Russia B.N. Yeltsin, Shunyakov Dmitriy V.
Published: May 2023

The paper analyses the practice of awarding law enforcement bodies after the establishment of the People’s Commissariat for Internal Affairs as a result of the merger between the Joint State Political Directorate (OGPU) and the Ministry of Internal Affairs of the Soviet Republics in 1933 until the beginning of the Great Patriotic War. It is stated here that the People’s Commissariat for Internal Affairs (NKVD) border and internal troops, which were part of the Soviet Armed Forces, took an active part in the armed conflicts with Japan and Finland. The study is based on historical method, objectivity and systematic approach. To process quantitative data on those awarded during the pre-war armed conflicts, the author used statistical analysis for calculating the results obtained by means of continuous sampling. Based on the archive materials, published data and personal sources, it is argued that at the time of the merger, the award systems of the OGPU and the Ministry of Internal Affairs were quite similar; for instance, they had similar departmental decorations. Further, it is pointed out that practically during the entire period under study, up to the establishment of a single departmental award “Honoured Worker of the NKVD” in 1940, similar earlier awards of the Cheka–OGPU and Workers’ and Peasants’ Militia were used. There were no awards to distinguish law enforcement activities; therefore, state labour decorations were often used instead. The award practice during the pre-war conflicts shows that employees of NKVD internal and border troops were distinguished similarly to Workers’ and Peasants’ Red Army officers, the number of the former being approximately 3 % of the total number of the awarded. During military operations, NKVD units and formations were put under the army command, making the rewarding of Chekists difficult since law enforcement bodies were linked to different people’s commissariats. The author concludes that state awards were rarely used to distinguish law enforcement activities. Primarily, NKVD employees and groups of employees were presented with departmental awards of material (valuable gifts, such as award weapon and money) and moral (certificates of merit and acknowledgement) nature.
Is the tax burden fairly distributed by developed nations? – a comparative study
Authors: Passos Beraldo Mariana , Passos Fernando , Abrantkoski Rister Carla
Published: May 2023

Background: Globalisation and fast growth in some developing economies significantly reduced the income gap between countries. However, globalisation has not necessarily resulted in equal distribution of benefits inside these countries.  Objective: The objective of this research was to verify whether there is a pattern in tax burden distribution policies in highly developed nations.  Method: The article adopted the literature review and a comparative data study as research methods and was structured in five chapters that complement each other within a logical sequence.  Results: The research showed that despite the development process presupposing sustainability and social inclusion, the developed nations do not equitably distribute the tax burden. The findings also demonstrated that there is no pattern in the tax policies.  Conclusions: The comparative analysis indicated that jurisdictions are exempting corporate income taxation to become more competitive in a global economy setting and are overtaxing individual income tax and employee taxation to compensate for the low tax on corporate income.   Contributions: The research results contribute to a growing body of literature that explores the relationship between the development of nations and levels of inequality and addresses the role of tax policies in this interrelationship. The research also presents practical contribution, being able to guide the formulation of tax policies that seek tax justice and aim at global tax governance.
materialmodifier: An R package of photo editing effects for material perception research
Authors: Tsuda Hiroyuki , Kawabata Hideaki
Published: May 2023

In this paper, we introduce an R package that performs automated photo editing effects. Specifically, it is an R implementation of an image-processing algorithm proposed by Boyadzhiev et al. (2015). The software allows the user to manipulate the appearance of objects in photographs, such as emphasizing facial blemishes and wrinkles, smoothing the skin, or enhancing the gloss of fruit. It provides a reproducible method to quantitatively control specific surface properties of objects (e.g., gloss and roughness), which is useful for researchers interested in topics related to material perception, from basic mechanisms of perception to the aesthetic evaluation of faces and objects. We describe the functionality, usage, and algorithm of the method, report on the findings of a behavioral evaluation experiment, and discuss its usefulness and limitations for psychological research. The package can be installed via CRAN, and documentation and source code are available at https://github.com/tsuda16k/materialmodifier.
Cassane diterpenoids with α-glucosidase inhibitory activity from the fruits of Pterolobium macropterum
Authors: Cheenpracha Sarot , Chokchaisiri Ratchanaporn , Ganranoo Lucksagoon , Bureekaew Sareeya , Limtharakul Thunwadee , Laphookhieo Surat
Published: May 2023

Two new cassane diterpenoids, 14β-hydroxycassa-11(12),13(15)-dien-12,16-olide (1) and 6′-acetoxypterolobirin B (3), together with a known analogue, identified as 12α,14β-dihydroxycassa-13(15)-en-12,16-olide (2), were isolated from the fruits of Pterolobium macropterum. Compound 1 is a cassane diterpenoid with a Δ11(12) double bond conjugated with an α,β-butenolide-type, whereas compound 3 is a dimeric caged cassane diterpenoid with unique 6/6/6/6/6/5/6/6/6 nonacyclic ring system. The structures of 1 and 3 were characterized by extensive spectroscopic analysis combined with computational ECD analyses. The α-glucosidase inhibitory activity of isolated compounds was evaluated, and compounds 1 and 3 showed significant α-glucosidase inhibitory activity with IC50 values of 66 and 44 μM.
Effect of chemical disinfection on the dimensional stability of polyvinyl ether siloxane impression material: a systemic review and meta-analysis
Authors:   King Khalid University, Saini Ravinder , Hassan Saeed , Alshadidi Abdulkhaliq
Published: May 2023

Review question / Objective: Does chemical disinfection effects the accuracy and dimensional stability of the dental impressions made from PVES elastomers?” Eligibility criteria: All in vitro studies with data on the effects of disinfection on PVES were included. Studies were selected based on the following criteria: (1) studies should have comparison data between native and disinfected PVES impressions, (2) methods of disinfection should be chemical disinfectants, and (3) studies published in English.pves,
Oxidative Stress in Patients with Congenital Heart Disease: A Systematic Review and Meta-Analysis
Authors:   Antwerp University Hospital, Vanreusel Inne , Hens Wendy , Taeymans Jan , Van Craenenbroeck Emeline , Van Berendoncks An , Paelinck Bernard , Segers Vincent , Briedé Jacob J.
Published: May 2023

Review question / Objective: To conduct a systematic review and meta-analysis of clinical controlled studies comparing parameters measuring oxidative stress in blood of patients with congenital heart disease (CHD). Main objective: to review studies on the presence of oxidative stress in both children and adults with CHD. Secondary objectives: - to review methods to assess oxidative stress levels in peripheral blood of CHD - to review factors with the potential to influence oxidative stress levels - to study whether there are therapeutic options targeting oxidative stress in CHD.
Psychosomatics of the impact of dental radiological investigations on the patient
Authors:   OMF Department, University of Medicine and Pharmacy, Science and Technology Targu Mures, Romania, Josan Lucian , Ormenisan Alina ,   OMF Department, University of Medicine and Pharmacy, Science and Technology Targu Mures, Romania, Teodorescu Elina ,   Orthodontic Department, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Stef Laura ,   Department of Dentistry and Nursing, ”Lucian Blaga” University of Medicine and Pharmacy, Sibiu, Romania, Salcudean Andreea ,   Psihiatric Department, University of Medicine and Pharmacy, Science and Technology Targu Mures, Romania, Pacurar Mariana ,   Orthodontic Department, University of Medicine and Pharmacy, Science and Technology Targu Mures, Romania
Published: May 2023

Radiological diagnosis in dental medicine is of overwhelming importance, helping the dentist to develop and justify his final diagnosis. They are increasingly common situations where diagnosis can only be determined radiologically. It is the patient's right to be informed about his or her state of health and at the same time we add a doctor's duty. In our material, we tried to highlight the impact on the patient the conducting and communicating the outcome of radiological investigations, to prove that there is fear of irradiation and to understand how the radiological image that demonstrates a poor orodental health entails the need for rehabilitation. This statistical study was performed on a total of 223 subjects (128 female subjects and 95 male subjects). The subjects of the study were asked questionnaires whose questions highlight the confirmation or rejection of the proposed objectives. The results obtained will show to what extent the patients have quantified the requirements of the questionnaires. Obtaining responses with a slightly surprising character certifies the rigor of our research.
A Fatal Neonatal Case of CHARGE Syndrome and Mini-Review of the Literature
Authors: SİRMA DOKUZBOY Refika , SARI Fatma Nur , CAKAR Esra Sukran , IŞIK Şehribanu , YAZICI Aybüke , ALYAMAC DİZDAR Evrim
Published: May 2023

In this article, we aim to represent a neonatal fatal case of CHARGE syndrome and make a mini-review of the literature to underline the wide range of congenital abnormalities and clinical symptoms of individuals with CHARGE syndrome face early in life. This patient, with his characteristic dysmorphic features, congenital heart defects, and severe feeding intolerance, is a good example of how complex the syndrome could be. CHARGE syndrome might affect numerous organ systems and result in severe early lethal cases for some, while some of the cases show a very mild phenotypic spectrum and may go unrecognized.
JİNEKOLOJİK KANSERLER NEDENİYLE OPERE EDİLEN VE YOĞUN BAKIMDA TAKİP EDİLEN HASTALARDA POLİFARMASİ YATIŞ SÜRESİYLE İLİŞKİLİ MİDİR?
Authors: ÜNSAL Mehmet , ZORLU Uğurcan , ÜNSAL Pelin , KARAASLAN Nur , ÖZCAN Namık , TURAN Taner
Published: May 2023

Özet

Amaç: Jinekolojik kanserler nedeniyle opere edilen hastalarda, hastaların operasyon öncesinde kullandığı ilaç sayısı ve potansiyel uygunsuz ilaç kullanımının yoğun bakım yatış süresiyle ilişkili olup olmadığını değerlendirmektir.

Gereçler ve Yöntem: Çalışmaya 2020 Haziran ve 2022 Aralık tarihleri arasında Ankara Bilkent Şehir Hastanesi Jinekolojik Onkoloji Cerrahisi Kliniği’nde endometrium, over, serviks ve diğer jinekolojik kanserler nedeniyle opere edilen ve operasyon sonrasında en az 24 saat yoğun bakımda takip edilen hastalar, retrospektif olarak dahil edilmiştir. Polifarmasi, 5 ve üzerinde ilaç kullanımı olarak tanımlanmıştır. Uygunsuz ilaç kullanımı için Türkiye Yaşlıda Uygunsuz İlaç Kullanım Kriterleri (TIME-to-STOP, TIME-to-START) kullanılmıştır.

Bulgular: Çalışmaya toplam 253 hasta dahil edilmiştir. 220 (%87) hasta endometrium kanseri, 25 (%9.9) hasta over kanseri, 2 (%0.8) hasta serviks kanseri, 6 (%2.4) hastada diğer jinekolojik kanserler nedeniyle opere edilip yoğun bakımda postoperatif takip edilmiştir. Hastalar postoperatif dönemde yoğun bakımda 2 gün (aralık; 1-21 gün) takip edilmiştir. Polifarmasi 34 (%13.4) hastada, potansiyel uygunsuz ilaç kullanımı ise 83 (%32.8) hastada bulunmuştur. Yoğun bakım yatış süresi ve ilaç sayısı arasında pozitif bir korelasyon izlenmiştir (r=0.142; p=0.024). Çok değişkenli regresyon analizinde, ilaç sayısı (OR:1.228 %95 CI:1.034-1.460, p=0.020) diğer tüm nedenlerden bağımsız olarak yoğun bakımda yatış süresiyle ilişkili bulunmuştur.

Sonuç: Jinekolojik kanserler nedeniyle opere edilen ve post operatif dönemde yoğun bakımda takip edilen hastalarda, polifarmasi yatış süresiyle ilişkilidir. Hastaların yoğun bakım kalış sürelerini ön görmek için her hastada, hastaların yatış öncesi ko-morbiditeleri ve ilaç kullanımlarını değerlendirmek anahtar noktalardan biridir.
ROBERTO BOLAÑO / SOPHIE PODOLSKI: LOCURA, INTERTEXTUALIDAD Y ANTIPSIQUIATRÍA
Authors: Corbatta Jorgelina
Published: May 2023

El objetivo de este ensayo consiste en el análisis intra/intertextual (e intersubjetivo) de “Compañeros de celda” (Llamadas telefónica) de Roberto Bolaño, centrado en la rescritura de la vida y obra de la poeta y dibujante belga Sophie Podolski, al interior de una trama intertextual y sociocultural que incluye a Philippe Sollers, Julia Kristeva y el grupo Tel Quel junto con los adherentes a la antipsiquiatría y a sus fundadores David Copper y David Lang.
South American terrestrial biomes as geocomplexes: a geobotanical landscape approach
Authors: Navarro Gonzalo , Luebert Federico , Molina José Antonio
Published: May 2023

The classic and current perception of biome in its various meanings is fundamentally based on vegetation types that are considered as discrete or independent and fragmented entities in the landscape. Vegetation units are characterized by their physiognomy, which is based on the dominant life forms and mainly determined by climatic conditions. However, vegetation units are associated and mutually interacting at a landscape level. They are determined by local or regional, climatic, topographic and edaphic gradients within a given territory or geographic area. In this work, we propose a new conceptual and methodological approach aiming to better understand the biome concept in a landscape framework, developing ideas already partially advanced by us. In this sense, we consider the biome as a landscape complex (geocomplex), that spatially includes one to several vegetation geoseries which, in turn, each comprise the following possible geomorphologically linked vegetation series: i) the potential natural climatophilic vegetation (zonal vegetation) and their seral successional stages which occur repeatedly in the landscape; ii) edapho-xerophyllous vegetation (azonal vegetation such as occurs on rocky outcrops or sandy soils); and iii) edapho-hygrophilic vegetation (azonal vegetation such as flooded vegetation on river banks). Based on surveys and field data (more than ca. 300 transects) obtained by the authors in most South American countries from 1990 to the present, 33 South American geocomplex biomes and 16 macrobiomes were identified and synoptically characterized, through graphic general zonation models (phyto-topographic type-profiles) extrapolated from numerous observations along representative bioclimatical, geomorphological and biogeographically stratified transects. Field data and transect-plots are currently being processed to be included into the “GIVD database”.

Taxonomic reference: Tropicos.org, Missouri Botanical Garden (https://tropicos.org) [accessed 1 Feb 2023].

In Memoriam: Salvador Rivas-Martínez
A remarkable new species of gecko (Squamata: Gekkonidae: Hemidactylus) from scrublands at the southern tip of India
Authors: Khandekar Akshay , Thackeray Tejas , Mariappan Rameshwaran , Gangalmale Satpal , Waghe Vivek , Pawar Swapnil , Agarwal Ishan
Published: May 2023

We describe a new species of Hemidactylus based on an integrative taxonomic framework from scrub habitats at the southern tip of India, in Thoothukudi District, Tamil Nadu. The new species has the most densely packed tubercles among Indian Hemidactylus, almost resembling the most tuberculate Indian Cyrtopodion. Hemidactylus quartziticolussp. nov. is phylogenetically placed within the brookii group of Indian Hemidactylus, where it is sister to the H. gleadowi complex from western-central India. The new species is 14.5–23.7% divergent in ND2 mitochondrial sequence data from other brookii group members, and can be easily diagnosed from regional congeners by its unique dorsal scalation, the number and arrangement of precloacal-femoral pores, the number of dorsal tubercle rows at midbody, number of lamellae under digit I and IV of manus and pes. The new species is currently known only from two isolated, low quartzite hillocks 45 km apart with scrubby, thorn forests and loose, stony soil.
Fuite des capitaux dans les pays d’Afrique subsaharienne : le rôle de la régulation et de la supervision bancaire
Authors: Diallo Askandarou Cheik
Published: May 2023

Cet article étudie la relation entre la fuite des capitaux, la régulation et la supervision bancaire dans les économies d’Afrique subsaharienne. Un panel de 23 pays sur la période 2000-2017 est utilisé à travers trois méthodes économétriques : FGLS (Feasible Generalized Least Squares), RE-GLS (Random Effects Generalized Least Squares) et les GMM (Generalized Method of Moments). Les résultats obtenus montrent qu’une bonne qualité de la régulation et de la supervision bancaire réduit l’incitation à la fuite des capitaux. Codes JEL: G11, O11.
Aider un proche aujourd’hui : état des lieux et perspectives
Authors: Trabut Loïc
Published: May 2023

Cet article propose de faire le point sur la situation des aidantes et aidants de personnes âgées dépendantes en France, en fonction du type et de la durée de leur investissement dans l’aide ainsi que de leur position sur le marché du travail. Il s’intéresse également aux effets de l’aide apportée sur leur santé. Il présente enfin des aspects prospectifs, bien sûr selon les scénarii de l’évolution démographique, annonçant une augmentation continue du besoin d’aide, mais aussi en fonction des transformations des formes familiales ou encore des nouvelles tâches assignées aux aidantes et aidants.
Parents de personnes autistes : des besoins spécifiques en tant qu’aidants
Authors: d’Eyssautier Armelle
Published: May 2023

Cet article s’intéresse aux besoins spécifiques des parents aidants de personnes autistes et propose une analyse des résultats de la deuxième édition de l’étude annuelle sur l’impact de la Stratégie nationale autisme et TND. Le rôle d’aidant n’est pas sans conséquence sur la qualité de vie de cette population fragilisée par les conséquences du handicap de leur enfant et d’autres facteurs impactant considérablement les vies personnelles et professionnelles. Ces besoins spécifiques et attentes des proches aidants pourraient être davantage pris en compte en structurant un soutien et un accompagnement de qualité tout au long du parcours de ces derniers. Ce soutien doit être multidimensionnel, prendre en compte la singularité des parcours et besoins des parents à chaque étape clé de leur vie d’aidant et de celle de leur proche en situation de handicap.
Histoire militaire
Authors: Soutou Georges-Henri
Published: May 2023

Le débarquement anglo-américain en Afrique du Nord, le 8 novembre 1942, marque une bascule majeure pour la France. Vichy perd le peu de sa souveraineté limitée tandis que Giraud et de Gaulle vont s’affronter en 1943, le premier se limitant à une approche militaire, le second ayant une vision géopolitique du conflit.
Solution of integral equations for multivalued maps in fuzzy $ b $-metric spaces using Geraghty type contractions
Authors: Ali Rashid , Mehmood Faisar , Saghir Aqib , Aydi Hassen , Mansour Saber , Kallel Wajdi
Published: May 2023

In this article, the notion of Hausdorff fuzzy $ b $-metric space is studied. Some fixed point results for multivalued mappings using Geraghty type contractions in $ G $-complete fuzzy $ b $-metric spaces are established. To strengthen the results, an illustrative example is furnished. A fuzzy integral inclusion is constructed as an application of fixed point result which shows the validity of the proved results. The presented outcomes are the generalization of the existing results in literature.
Analytical solutions for nonlinear systems using Nucci's reduction approach and generalized projective Riccati equations
Authors: Yépez-Martínez Huitzilin , Hashemi Mir Sajjad , Alshomrani Ali Saleh , Inc Mustafa
Published: May 2023

In this study, the Nucci's reduction approach and the method of generalized projective Riccati equations (GPREs) were utilized to derive novel analytical solutions for the (1+1)-dimensional classical Boussinesq equations, the generalized reaction Duffing model, and the nonlinear Pochhammer-Chree equation. The nonlinear systems mentioned earlier have been solved using analytical methods, which impose certain limitations on the interaction parameters and the coefficients of the guess solutions. However, in the case of the double sub-equation guess solution, analytic solutions were allowed. The soliton solutions that were obtained through this method display real positive values for the wave phase transformation, which is a novel result in the application of the generalized projective Riccati method. In previous applications of this method, the real positive properties of the solutions were not thoroughly investigated.
Embodying the colonial memory. White colonists and “implicated subjects” in photographs from Equatorial Guinea
Authors: Plasencia Camps Inés
Published: May 2023

Except for explicitly colonial approaches, academic research on the visual culture of former colonies tends to adopt an allegedly critical perspective towards colonial history, as a way to participate in the construction of a conscious memory that helps to transform contemporary relationships. However, for a while, the hypervisibility of colonised peoples has been compared to the lack of visibility of white colonisers in academic studies. In line with theories of cultural memory, this study examines images as critical cultural artefacts to argue that racial deidentification in images of colonial Equatorial Guinea takes the focus away from the current society of the former metropolis, and thus from its memory and its colonial responsibility. I present a theoretical approach to photographs of white people ranging from the early 20th century to family images during the final years of colonial domination (1959-1968). These chiefly depict everyday scenes whose protagonists are apparently oblivious to the colonial context, and in which nothing seems to happen, in the same way, that their descendants, understood collectively, are enabled to ignore the colonial past and its continuities.
Hermann Klaatsch and his photographic representations of Australian aborigines during his scientific trip through Australia (1904-1907)
Authors: Pelayo Francisco
Published: May 2023

The German anatomist and palaeontologist Hermann Klaatsch arrived in Australia to study the aborigines in March 1904. The aim of his trip was to continue his research on the phylogenetic history of humanity and test his colleague at the University of Heidelberg Otto Schoetensack’s hypothesis that Australia was the cradle of humankind. He travelled the country’s coastline without interruption, except for a trip of a few months to Java, until May 1906. During his trip, which also included Tasmania, Klaatsch studied the aborigines from an anthropological, craniological, and material culture perspective, taking notes, making drawings, taking photographs of the natives, and compiling ethnographic collections which were dispatched to several German museums. Klaatsch made nearly 400 photographs of Australian natives and took plaster casts of the foot of an individual, owing to its atavistic anatomy. This latter generated a misunderstanding in a local newspaper that soon reached the international media, about the alleged discovery of the “missing link” in Australia. On his return from Australia in April 1907, Klaatsch was appointed extraordinary professor in anatomy, anthropology and ethnography, and curator of collections at the anatomical institute and the ethnological museum at the University of Breslau (Wroclaw, Polonia).
Kartagener Syndrome with Pan Atopic Airway Disease
Authors: Aakanksha  , Kunjumon Saby Anna , Utpat Ketaki Vasudeo , Desai Unnati , Bharmal Ramesh
Published: May 2023

Kartagener syndrome (KS) is a rare type of primary ciliary dyskinesia, which comprises a triad of chronic sinusitis, situs inversus, and bronchiectasis. It has a heterogeneous inheritance, mainly inherited as an autosomal recessive disorder, causing functional defect in ciliary movement. Bronchial asthma (BA) is a disease where there is a chronic inflammation of airways along with hyperreactive airways with variable airflow obstruction. We are reporting a case of a 36-year-old man with chronic sinusitis, situs inversus totalis, bronchiectasis, and well-controlled asthma. This case report orients toward the fact that KS can present with BA which makes this case idiosyncratic. Moreover, the veracious takeaway lesson is that early diagnosis will improve the quality of life of the patients and reduce the complexities of the disease, thus will bring down the morbidity and mortality of the patients.
A Case of Resolving Pontine Hemorrhage
Authors: Rao Gurukanth , Vaibhav S. , Belle Jayaprakash
Published: May 2023

Generally, Pontine hemorrhages though rare have poor prognosis with 48.1% all-cause mortality noted. A grim statistic which becomes worse if the patient presents to the hospital with depressed sensorium. Level of consciousness and hemorrhage size constitute two of the most important prognostication factors for patients with pontine hemorrhage. Here we present a case of a young lady who presented with poor sensorium and a large pontine hemorrhage who went on to return to good recovery status, modified Rankin Score 2 with conservative intervention.
Estimation of Novel Anthropometric Measurements among Normoglycemic Persons, Prediabetes, and Diabetes in the Indian Population: An Analytical Cross-Sectional Study
Authors: Jayashankar C. A. , Mukherjee Projoy , Dwarakanathan Vignesh , Manohar Akshatha , Pinnelli Venkata Bharat Kumar
Published: May 2023

Background:

Central obesity is a risk factor for the development of diabetes mellitus (DM) and can be measured using various anthropometric measurements.

Aim:

This study is done to estimate novel anthropometric markers of obesity such as mid-upper arm circumference (MUAC), wrist circumference (WrC), waist–height ratio (WHtR), and neck circumference (NC) in healthy individuals, prediabetes, and DM.

Methods:

This was a cross-sectional study among 58 normoglycemic healthy volunteers, 59 prediabetics, and 59 diabetics in a tertiary care center from India. Participants were tested for fasting plasma glucose, postprandial plasma glucose, and glycated hemoglobin. Anthropometric measurements were done. We used partial ordinal regression to look for the association between anthropometric markers and diabetic status.

Results:

NC, MUAC, WrC, and WHtR were significantly higher in and highest in diabetics compared to controls. They significantly correlated with body mass index. They had significantly higher odds (odd ratio [OR1] NC – 1.60, OR1 WrC – 1.92, OR1 MUAC – 1.45, and OR1 WHtR – 1.33) for control to prediabetes. OR of only WHtR was significant for prediabetes to diabetes (OR2 WHtR– 1.10).

Conclusion:

Association of novel anthropometric markers was significant for prediabetes compared to controls, but not significant for diabetes compared to prediabetes.
A Clinical Approach to Diagnosis and Management of Vertigo in the Emergency Room Setting
Authors: Gupta Manish , Gupta Monica , Gupta Akanksha
Published: May 2023

Vertigo is a symptom of the illusory movement of spinning. Vertigo is a challenging diagnostic condition in the emergency room as it is a symptom-complex of a large number of benign to life-threatening conditions. Both peripheral vestibular and central nervous system can cause vertigo and it is often impossible to pinpoint the underlying etiology in the acute settings. Historical features such as recurrent vertigo, triggers, duration of vertigo, accompanying symptoms along with meticulous vestibular, and ocular and balance examination can be valuable in delineating peripheral from central vertigo. Currently, the emergency physicians approach majority of vestibular disorders with a mind-set of preventing any errors of omission, so they rely on unwarranted neuroimaging. In most instances, the timing and triggers of vertigo are ignored and characteristic maneuvers to diagnose benign peripheral vertigo are underused, thereby missing nonlife-threatening diagnosis. An urgent neuroimaging is usually indicated for patients with sustained vertigo and suspected central lesions associated with brainstem dysfunction.
Sitagliptin Reduces Urinary Microalbumin and the Histopathological Damage of the Kidneys in an Experimental Model of Diabetic Nephropathy
Authors: Tsavdaridis Ioannis , Karanikola Theodora , Karayannopoulou Georgia , Papadimitriou Dimochristos , Katsouda Areti , Foka-Karagiannopoulou Aikaterini , Mironidou-Tzouveleki Maria
Published: May 2023

Purpose:

In this study, we aimed to explore the effects of sitagliptin on diabetic nephropathy using an experimental animal model while referring to various aspects of the Dipeptidyl peptidase- IV inhibitors literature findings.

Methods:

27 male BKS.Cg- + Leprdb/+ Lepr/+ OlaHsd mice, 8 weeks old, were evenly separated into three groups. For 12 weeks, group D and L received a high (200 mg/Kgr/day) and low (10 mg/kg/day) dosage of sitagliptin, respectively, while group N did not receive any treatment. Biochemical tests on urinary and blood samples of each animal as well as histopathological examination for specific lesions of the kidneys were performed at the end of the experimental study.

Results:

Both high (D) and low (L) sitagliptin dosage were found to significantly reduce serum glucose, microalbumin, and albumin to creatinine ratio (ACR) when compared with the control group, while high sitagliptin dose, additionally, showed a significant reduction of urinary creatinine (P < 0.01). Moreover, sitagliptin had a positive effect on histopathology findings; sitagliptin significantly reduced moderate/severe mesangial matrix expansion (P < 0.001 for both groups), thickening of the basal membrane, vascular pole hyalinosis capsule cell hyperplasia, and thickening of the Bowman’s capsule compared with control group.

Conclusion:

Sitagliptin appears to improve the biochemical parameters regarding kidney function and acts beneficially by reducing the extent of renal histopathological damage caused by DM.
The Clinical Profile and Long-Term Outcome of Children with Membranous Nephropathy, and the Evaluation of Anti-Phospholipase A2 Receptor Antibody Immunohistochemistry in Kidney Biopsy
Authors: Deepthi RV , George Sachin , Mathew Georgie , Roy Sanjeet , Bindra Mandeep , Rebekah Grace , Agarwal Indira
Published: May 2023

Introduction:

Idiopathic membranous nephropathy (iMN) is a rare cause of nephrotic syndrome in children (1%–7%). Anti-phospholipase A2 receptor (PLA2R) antibody positivity in kidney biopsy is observed in 52%–78% of adults and 45% of children with iMN. The objectives of the study are to analyze the clinical profile and outcome of membranous nephropathy in children, to assess the prevalence of anti-PLA2R immunohistochemistry (IHC) in kidney biopsy, and to correlate their presence with disease characteristics.

Methods:

We are reporting a single-center retrospective study conducted in pediatric nephrology division. Clinical data and outcome parameters of children with membranous nephropathy were analyzed. PLA2R IHC was performed in kidney biopsy specimens retrospectively.

Results:

We analyzed 43 children with membranous nephropathy (MN) from a single center. 18 (42%) had idiopathic MN (iMN). PLA2R IHC was performed in kidney biopsy specimens in 14/18 (78%) patients with iMN and 7/9 (78%) non-lupus secondary membranous nephropathy (SMN) patients. The most common cause of SMN was lupus nephritis in 16 patients (64%). The mean estimated glomerular filtration rate (eGFR) at onset was 156 ± 81 ml/min/1.73m2. The sensitivity and specificity of PLA2R IHC in diagnosing pediatric MN was 50% and 57%, respectively; positive and negative predictive values were 70% and 36%, respectively. At the final follow-up, chronic kidney disease stage 5 (CKD 5) developed in 2/14 (14.3%) iMN patients.

Conclusions:

IHC PLA2R staining of glomerular tissue is a useful diagnostic marker of IMN. Though PLA2R prevalence is lower in children, its role in guiding treatment needs further exploration.
Phenotype Spectrum in Tunisian Population with NPHP1 Deletion
Authors: Hammi Yousra , Ferjani Maryem , Meddeb Rym , Kacem Rania , Sayari Taha , Mrad Ridha , Gargah Tahar
Published: May 2023

Introduction:

Nephronophthisis (NPHP) is a tubulointerstitial kidney disorder with an autosomal recessive inheritance pattern. Its genetic heterogeneity contributes to phenotype variability. The most frequent etiology of juvenile nephronophthisis is a mutation in the nephronophthisis type 1 (NPHP1) gene. This study aimed to evaluate the genotype-phenotype correlation in NPHP1 gene mutation.

Methods:

A multicenter retrospective study was performed over 20 years from 1998 to 2018 to describe the clinical, biological, and radiological features associated with the large deletion NPHP1 gene in 32 patients.

Results:

The incidence of NPHP1 was 1.6/204041. Eighty-one percent of our patients were born out of consanguineous marriages. The mean age at diagnosis was 14 ± 7 years. The patients were divided into three groups: isolated nephronophthisis (72%), syndromic nephronophthisis (19%), and patients without recognizable syndrome (9%). Intrafamilial and geographical variability was observed in syndrome diagnoses and in age at the onset of CKD stage 5. Genotype frequency varied between 50% and 100% in genealogical data. Juvenile (47%), adolescent (37%), and adult (13%) clinical forms have been distinguished by the onset of CKD stage 5. The five-year survival rate of renal transplantation was 80%.

Conclusion:

Given the broad clinical spectrum of NPHP1 associated with the large deletion of the NPHP1 gene, no genotype-phenotype correlation could be established.
Sinonasal teratocarcinosarcoma in an adolescent male: A case report of an unusual neoplasm
Authors: Soman Aashna , Prasad P. H. , Ajayan P. V.
Published: May 2023

Sinonasal teratocarcinosarcoma (SNTCS) is an extremely rare and aggressive malignant tumor arising in the sinonasal tract, having a combined clinicopathological feature of teratoma and carcinosarcoma. It shows a male predominance and affects adults with an age range of 18–79 years and a mean age of 60 years. Here, we report a case of SNTCS in a 14-year-old male patient who presented with swelling over the upper right alveolus and pain in the right jaw for 2 months. The tumor was completely removed by right total maxillectomy with orbital mess reconstruction, and postoperative radiotherapy with chemotherapy was given. The follow-up of the patient for 2 years has shown evidence of recurrence and is now on palliative care.
“Efficacy of cytotoxic effect of green tea catechins on the human periodontal fibroblasts and human dental pulp fibroblasts -An in vitro study”
Authors: Hattarki Sanjeevini , Bogar Chetana , Bhat Kishore
Published: May 2023

Background:

Inflammation of tooth-supporting tissue and the pulp tissue is followed by wound healing and regeneration process that involves the specific type of connective tissue cells, the fibroblasts. During periodontitis and pulpitis, the inflammation of the tissue causes damage to the fibroblasts. These fibroblasts secrete collagen proteins and maintain the structural framework; along with this the inflammatory process moves toward healing where in the specific cells such as the fibroblast cells play important roles. Green tea catechins epigallocatechin-3-gallate (EGCG) being one of the major catechins is known to have multiple beneficial effects on human fibroblasts.

Objective:

To assess the in vitro cytotoxicity of green tea catechins on the human periodontal ligament (PDL) fibroblasts and human dental pulp fibroblasts.

Materials and Methods:

Human PDL fibroblasts (hPDLFs) and human dental pulp fibroblasts were isolated from the two extracted premolar teeth that were indicated for orthodontic treatment. The fibroblasts were then seeded in 96 well tissue culture plate for cell viability study. EGCG was used at different concentration to treat the cells. After 48 h; (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) (MTT) assay was performed to determine the cell viability.

Results:

The vitality of hPDLFs and human dental pulp fibroblasts was found to be inversely proportional to EGCG concentrations.

Conclusions:

hPDLFs have shown 37% proliferation at lowest concentration of EGCG used and human dental pulp fibroblasts have shown 99% viability at lowest concentration of EGCG used.