bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of adipokines in the formation of metabolic disorders in conditions of metabolic-associated fatty liver disease (MAFLD)
Authors: Livzan M. A. , Krolevets T. S. , Syrovenko M. I.
Published: March 2024

The aim of this review is to summarise the current knowledge on the role of adipokines on the development and progression of MAFLD. Discussion: diagnostic criteria for metabolic-associated liver disease (MAFLD) versus non-alcoholic fatty liver disease (NAFLD) are presented. The pathogenetic aspects of metabolic disorders in MAFLD are discussed. The potential role of various adipokines such as leptin, resistin, vasfastin, ghrelin, adiponectin and others is considered. Data from our own studies and foreign studies are presented. Conclusion: given the pandemic growth of MAFLD and its association with cardiovascular risk and obesity, the question of how to properly curate patients with comorbid to reduce risks is timely and highly relevant. Adipokines contribute significantly to the pathogenesis of MAFLD. Among all, leptin and adiponectin are the most promising and well studied. That is why strategies aimed at restoring leptin and adiponectin balance may have an impact on the course of MAFLD.
Functional nutrition option patients with non-alcoholic fatty liver disease
Authors: Baranovsky A. Yu. , Kruglova N. A. , Grigoreva E. Yu.
Published: March 2024

The results of a study of the clinical efficacy of dietary treatment in patients with non-alcoholic liver disease (NAFLD) with the additional inclusion of a new specialized nutritional functional dietary product “A mixture of essential nutrients multicomponent dry” (SENMS) in the product content of the standard D3 diet are presented. 75 patients with NAFLD were examined (39 - study group, 36 - control group). The patients in the study group received 6 g of SENMS daily for 2 weeks, consisting of 6 ingredients that are sources of biologically active substances: inulin, green tea extract, dry red wine extract, L-carnitine, grape seed extract, coenzyme Q10. As a result of the conducted study, it was proved that the SEMS in patients with NAFLD contributed to a faster decrease in the severity of hepatic parenchymal inflammation compared with the control, improved cholesterol metabolism, lipid peroxidation, and quality of life indicators of patients. In conclusion, the expediency of using a new specialized functional dietary food product “A mixture of essential nutrients multicomponent dry” in dietary treatment programs for patients with NAFLD was noted.
Cholelithiasis in a patient with hereditary spherocytosis
Authors: Shklyaev A. E. , Zaitseva V. V. , Bessonov A. G. , Dudarev V. M.
Published: March 2024

The article presents a clinical observation of a patient with hereditary hemolytic anemia and cholelithiasis that developed from it. The record of ultrasound of the abdominal, magnetic resonance cholangiopancreatography, and the movement of laboratory parameters are demonstrated. The patient underwent splenectomy with cholecystectomy, the information of the postoperative period are presented. The purpose of the article was to study, using the example of this clinical case, the features of the course of hereditary spherocytosis complicated by cholelithiasis in an adult patient; to assess the feasibility of the presented variant of the tactics of managing patients with this pathology. It is shown that at the present stage, despite the dynamic pace of development, pharmacology does not offer effective therapy, and splenectomy remains the only method for treating hereditary spherocytosis. Removal of the spleen eliminates intrasplenic hemolysis and therefore corrects the anemia. With the development of gallstone disease as a result of hemolysis, splenectomy is performed in combination with cholecystectomy.
Features of the course of irritable bowel syndrome in overweight and obese people
Authors: Fedorin M. M. , Livzan M. A. , Gaus O. V.
Published: March 2024

The aim of the study: to study the characteristics of the course of irritable bowel syndrome (IBS), associated with overweight and obesity, to optimize the management of this group of patients. Material and methods. An open-label cross-sectional study was performed including 175 participants aged 18 to 44 years (mean age 30.06 ± 6.15 years). Group 1 included 100 patients with IBS aged 18 to 44 years (mean age 30.63 ± 6.37 years, BMI 25.88 ± 6.28 kg/m2). In group 1, subgroup 1A included 50 people with IBS associated with overweight or obesity. Subgroup 1B included 50 IBS patients with normal weight. Group 2 included 75 people who did not suffer from IBS, aged from 19 to 43 years (mean age 29.31 ± 5.81 years, BMI 27.80 ± 6.20 kg/m2). Subgroup 2A included 50 participants who did not suffer from IBS and were overweight or obese. Subgroup 2B included 25 apparently healthy participants. The presence and severity of IBS symptoms were assessed using a 10-point scale. The severity of gastrointestinal symptoms, the presence of anxiety and depression, the level of specific anxiety, quality of life and eating habits were assessed using verified questionnaires. All participants underwent a study of the levels of leptin and adiponectin in the blood serum and zonulin in the feces. Results. The characteristic clinical stigmas in patients suffering from IBS associated with overweight and obesity are described: IBS with a predominance of constipation, severe course of the disease, high incidence of signs of depressive and anxiety disorders, special eating habits characterized by the predominance of flour, sweet, fatty and salty foods in the diet food, severe disturbances in the permeability of the intestinal epithelial barrier. High concentrations of leptin and low levels of adiponectin in the blood serum of such patients may play a significant role in the formation of IBS symptoms. Conclusion. The results obtained open up opportunities for research into the pathogenetic mechanisms of the formation of IBS in people with overweight and obesity, as well as modification of existing treatment regimens for patients with IBS.
ND70 series basaltic glass reference materials for volatile element (H2O, CO2, S, Cl, F) analysis and the C ionisation efficiency suppression effect of water in silicate glasses in SIMS analysis.
Authors: Moussallam Yves , Towbin William , Plank Terry , Bureau Hélène , Khodja Hicham , Guan Yunbin , Ma Chi , Baker Michael , Stolper Edward , Naab Fabian , Monteleone Brian , Gaetani Glenn , Lee Hyun Joo , Ding Shuo , Shi Sarah , Rose-Koga Estelle
Published: March 2024

We present a new set of reference material, the ND70-series, for in situ analysis of volatile elements (H2O, CO2, S, Cl, F) in silicate glass of basaltic composition. Samples have been synthesised in piston cylinders at pressures of 1 to 1.5 GPa at volatile-undersaturated conditions. They span concentrations from 0 to 6 wt.% H2O, from 0 to 1.6 wt.% CO2 and from 0 to 1 wt.% S, Cl and F. The samples have been characterised by Elastic Recoil Detection Analysis (ERDA) for H2O, by Nuclear Reaction Analysis (NRA) for CO2, by Elemental Analyser (EA) for CO2, by Fourier Transform Infrared Spectroscopy (FTIR) for H2O and CO2, by Secondary Ion Mass Spectrometry (SIMS) for H2O, CO2, S, Cl and F, and by Electron Microprobe (EMP) for CO2, S, Cl, and major elements. Comparison between expected and measured volatile amounts across techniques and institutions is excellent. It was found however that SIMS analyses of CO2 concentrations using either Cs+ or O– primary beams are strongly affected by the glass H2O content. Reference materials are being distributed at Ion probe facilities in the US, Europe and Japan. Remaining reference materials will be deposited at the Smithsonian National Museum of Natural History where they will be freely available on loan to any researcher.
Exploring Challenges Towards Learning Mathematics Among Secondary School Students in Nepal
Authors: Pokhrel Maheshwor
Published: March 2024

Mathematicians had been concerned with everyday problems. However, today's students are uninterested in learning mathematics. The main objective of this research is to identify students' challenges to learning mathematics. Employing an interpretative research paradigm, the study utilizes a narrative research design involving eight students from public and private schools in the Kaski district. To achieve the research objective, in-depth interviews were conducted with research participants. I had narrated views about challenges towards learning mathematics from my participants. After analysis and interpretation of data, challenges towards learning mathematics were difficulties in learning mathematics, negative perception and external pressure, disruption in learning environment and foundation, changing teacher and lack of support, enjoyment in mathematics practice and fear of teacher, barriers in conceptual clarity and guidance, obstacles in effective mathematics teaching and disinterest, unclear teaching and insufficient support respectively. Moreover, Students face a multitude of challenges in learning mathematics, including issues related to teacher behavior, lack of motivation, the current curriculum, low parental socio-economic status, ineffective teaching strategies, poor home environments, low academic achievements, math anxiety, impractical curricula, and traditional teaching methods.
गणतन्त्र नेपालको स्थापनामा संसद र मिडियाको योगदान
Authors: नेपाल Nepal जगत Jagat
Published: March 2024

प्रस्तुत अनुसन्धानात्मक लेख नेपालमा गणतन्त्र स्थापनाका पक्षमा जनमत बनाउन संसद र मिडियाले गरेको योगदानमा केन्द्रित छ । २०५८ जेठ १९ गतेको दरवार हत्याकाण्डमा राजा वीरेन्द्रको वंशनाश भएपछि गद्दीको उत्तराधिकारी बनेका राजा ज्ञानेन्द्रले संविधान मिचेर २०६१ माघ १९ गते प्रधानमन्त्री शेरबहादुर देउवालाई वर्खास्त गरी आफ्नै अध्यक्षतामा मन्त्रिमण्डल गठन गर्नु, मिडियामा सैन्य सेन्सरसीप लगाउनु, एकद्वार विज्ञापन नीतिका नाममा आर्थिक नाकाबन्दी लगाएर स्वतन्त्र सञ्चार माध्यमलाई आफै बन्द हुने अवस्थामा पु¥याउन खोज्नु, शाही कदमको विरोधमा लेख्ने पत्रकारलाई पक्राउ गर्नु जस्ता कारण नेपाली मिडियाले राजा र राजपरिवारका नकारात्मक पक्षलाई बढी महŒव र प्राथमिकताका दियो । जनअधिकार खोसेर दरवारलाई बलियो बनाउने राजाको कदमले सात संसदवादी दल र विद्रोही दुवै शक्तिलाई १२ बुँदे सहमित गरी राजतन्त्र विरुद्ध सङ्घर्ष गर्ने विन्दुमा पुर्याई दियो । त्यही सहमतिको बलमा ‘निरंकुश राजतन्त्रको अन्त्य र पूर्ण प्रजातन्त्रको स्थापना’ का लागि सुरु भएको २०६२–२०६३ को जनआन्दोलनमा गणतन्त्रको मुद्दा जोडतोडका साथ उठ्यो । राजाबाट पटक पटक प्रजातन्त्र अपरहण भएकाले राजतन्त्र रहँदासम्म प्रजातन्त्र सुरक्षित रहन सक्दैन भनेर जनताले सडकबाट उठाएको आवाजलाई उच्च प्राथमिकताका साथ समाचार, विचार र सम्पादकीयमा स्थान दिँदै नेपाली मिडियाले राजालाई विष्णुको अवतार मान्ने नेपाली समाजमा राजतन्त्र नभए पनि देश चल्न सक्छ भन्ने जनमत निर्माणमा योगदान गर्यो । आन्दोलन गणतन्त्रउन्मुख भएपछि राजा संसद पुनर्स्थापना गर्न बाध्य भए । पुनस्र्थापित संसदले क्रमशः राजाका राजनीतिक र सांस्कृतिक अधिकार कटौती गर्दै गणतन्त्रको आधार बनाउँदै गयो । त्यही बेला नेपाली प्रेसले राजतन्त्र रहँदासम्म प्रेस स्वतन्त्रता र नागरिक अधिकारको रक्षा हुन नसक्ने ठहर गर्दै गणतन्त्रमा जानुको विकल्प छैन भन्ने सन्देश प्रवाह गर्यो । यो लेख पुनर्स्थापित संसदबाट राजाका अधिकार कटौती गर्दै २०६५ जेठ १५ गते संविधानसभाको पहिलो बैठकबाट गणतन्त्र कार्यान्वयन गर्दासम्मको कालखण्डमा संसद र नेपाली मिडियाले गरेको योगदानमा केन्द्रित छ ।
सुशासनका लागि डिजिटल मुद्रा तथा विद्युतीय भुक्तानी प्रणाली {Digital Currency and Electronic Payment System for Governance}
Authors: ढकाल Dhakal टिकाराम Tikaram
Published: March 2024

वस्तु तथा सेवाको विनिमयमा विश्वभर नै प्रयोग हुने वस्तु मुद्रा हो। कुनैपनि देशको आर्थिक प्रणाली त्यस देशको मुद्रा तथा भुक्तानी प्रणालीमा प्रत्यक्ष निर्भर रहेको हुन्छ। नेपाल लगायत विश्वभरी परम्परादेखि नै नोट तथा सिक्काको रुपमा भौतिक मुद्राको प्रयोग हुँदै आएको पाइन्छ तर पछिल्लो समयमा क्रिप्टोकरेन्सीको प्रयोग समेत बढ्दै गएको छ भने केन्द्रीय बैंकले निष्काशन गर्ने डिजिटल   मुद्राको प्रयोग पनि बढ्दो छ। नेपाल लगायत विश्वका अधिकांश मुलुकहरुमा हालको भौतिक मुद्रा बैंक खातामा राखी सो बराबरको रकम विभिन्न प्लेटफार्म प्रयोग गरी विद्युतीय माध्यमबाट कारोबार तथा रकम भुक्तानी हुने गरेको पाइन्छ। कुनैपनि विनिमयमा कारोबार तथा भुक्तानी हुने भौतिक मुद्राको प्रयोग हुँदा यसको गलत प्रयोग हुन सक्ने, गैरकानुनी तवरले रकम नगदको रुपमा व्यक्तिले राख्न सक्ने गुन्जायस रहन्छ तर डिजिटल मुद्राको अवलम्बन गरी शतप्रतिशत विद्युतीय माध्यमबाट भुक्तानी तथा कारोबार हुन सकेमा सबै कारोबार कानुनी दायरामा आइ सरकारको कर प्रणालीमा सुधार हुने, राजस्व वृद्धि हुने तथा भ्रष्टाचार नियन्त्रण हुन टेवा पुग्ने देखिन्छ। यो लेख तयार गर्दा राष्ट्रिय तथा अन्तर्राष्ट्रिय रुपमा प्रकाशित लेख रचनाहरु एवम् विभिन्न प्रतिवेदनको अध्ययन तथा विश्लेषण गरी डिजिटल मुद्राको प्रयोग सुरुवात गरेका केही राष्ट्रहरुले यस्तो प्रणाली लागु गरेपश्चात प्राप्त गरेका पृष्ठपोषण र सुधारका प्रयासहरुको समेत अध्ययन गरी निष्कर्ष निकालिएको छ।
व्यवसायिकता र निष्ठाको कसीमा निजामती सेवा {A civil service based on professionalism and integrity}
Authors: थानी Thani दिनेश प्रसाद Dinesh Prasad
Published: March 2024

निजामती सेवामा व्यवसायिकता र निष्ठाको वर्तमान स्थिति र यसको प्रयोगको अवस्था हेर्दा यससँग सम्बन्धित नीतिगत तथा कानुनी व्यवस्था, सिद्दान्त र व्यवहारमा मेल खाएको देखिंदैन। हाल निजामती सेवा निकै अप्ठ्यारो स्थितिमा गुज्रिरहेको देख्न सकिन्छ। यसले शुरुवात देखि हालसम्म प्राप्त गरेको साख जोगाइ राख्‍नु र सेवाकै दिगो निरन्तरता समेत चुनौतीपूर्ण नहोला भन्न सकिन्न। यसो हुनुको पछाडि राजनीतिक नेतृत्व मुख्य रुपमा जिम्मेवार त छँदैछ, निजामती सेवा हाँक्ने पदमा बसेका अधिकांश अधिकारीहरु पनि कम जिम्मेवार छैनन्।  निजामती सेवाको संरक्षक राजनीतिक नेतृत्व नै हो, यसमा विवाद छैन तर राजनीतिक नेतृत्वको प्रकृति अस्थायी हुन्छ, तसर्थ स्थायी सरकारको रुपमा रहेको प्रशानिक नेतृत्वले नै निजामती सेवामा कसरी व्यवसायिकता र निष्ठा कायम गर्न सकिन्छ र कसरी यसको थप विकास गर्न सकिन्छ भन्ने तर्फ विशेष ध्यान दिन जरुरी हुन्छ।  निजामती सेवाको उच्च पदमा रहेका प्रशासकहरुको व्यवहार र कार्यशैली हेर्दा यस वारेमा पटक्कै ध्यान नदिएको आरोप नागरिक तह र आमसञ्चार माध्यमबाट लाग्ने गरेको छ। निजामती सेवामा कार्यरत सचिवहरु, सह-सचिवहरु, उपसचिवहरु लगायत शाखा अधिकृत, नायव सुब्बा, खरिदार र कार्यालय सहयोगी सम्मै राजनीतिक पार्टी र त्यसका फ्रन्ट लाइनका नेताहरुको चाकडी गरेर मालदार मन्त्रालय, विभाग र कार्यालयमा सरुवा तथा पदस्थापना हुने मात्र होइन, मुलुक बाहिर समेत पदस्थापना हुन सकिने विभिन्न स्थान प्राप्त गर्न लागिपरेको जस्ता आरोपहरु सर्वसाधारण जनताबाट लाग्ने गरेको छ। निजामती सेवाको विशिष्टीकृत कानुनका रुपमा रहेको निजामती सेवा ऐन र नियमावलीमा भएका प्रावधानहरुको व्यवहारमा कार्यान्वयनको स्थिति निकै फितलो देखिन्छ। पदस्थापना, सरुवा, बढुवा र कार्यसम्पादन मूल्यांकन जस्ता विषयहरुमा निश्चित मापदण्ड बनाइएको छैन जसका कारण यी विषयहरु सधैंजसो विवादित भईनैरहेका छन्।  यसले गर्दा निजामती सेवाको मूल्य र मान्यता नै धरापमा पर्न सक्ने खतरा छ। जनतालाई उपलब्ध गराउनुपर्ने सेवाको प्रभावकारिता पनि सन्तोषजनक देखिंदैन। यी र यस्ता विविध कारणले गर्दा सिंगो निजामती सेवा प्रति नै जनताको दृष्टिकोण त्यति सकारात्मक देखिएको छैन। वर्तमानमा देखिएको यस्तो स्थितिलाई तत्काल सुधार गरी जनताको नजरमा निजामती सेवाको साख कायम राख्‍न र जनमैत्री सेवाका रुपमा स्थापित हुन निजामती सेवामा व्यवसायिकता र निष्ठा महत्वपूर्ण हुन्छ।  यसका लागि शासकीय र प्रशासकीय दुवै पक्ष उत्तिकै जिम्मेवार हुनुपर्ने र आ-आफ्ना कार्यव्यवहार र कार्यशैली राष्ट्रिय हित र जनमैत्री बनाउँदै संविधान र कानुनको पूर्ण परिपालना गरी जनतालाई छिटो छरितो र  कम लागतमा प्रभावकारी सेवा उपलब्ध गराई जनताको विश्वास जित्न अपरिहार्य देखिन्छ।
Analisis Program Alokasi Dana Desa (ADD) Dalam Pemberdayaan Masyarakat Desa Di Desa Bangun Sari Deli Serdang Tahun 2018
Authors: Lubis Disa Devalia Rizki Aranda , Kadir Abdul , Lubis Yurial Arief
Published: March 2024

Program Alokasi Dana Desa (ADD) is an implementation Alokasi Dana Desa through physical and no-physical development. This research background by program Alokasi Dana Desa (ADD) in empowering village communities at Desa Bangun Sari namely the KDRT prevention program that was established in 2018 where this program could not be realized with a total of Rp 41.000.000-, funds. This study aims to analyze the program Alokasi Dana Desa in the empowerment of rural communities, namely the KDRT program and what are the obstacles for not realizing the program. As for the method used in this study is a descriptive qualitative method. In this study, researchers used three informants who knew as well additional informants. There are two ways to collect data, namely secondary data such as book, journals and documentation, while primary data such as interview and observation. From the result of the above research it can be seen that the program analysis Alokasi Dana Desa (ADD) in empowering village communities at Desa Bangun Sari in 2018 not maximal enough in its application which cab ve examined throught three program indicators according to chareles, namely organizing, interpretation and application.
Kepemimpinan Kepala Desa dalam Meningkatkan Kinerja pada Kantor Desa Sukamaju Kecamatan Sunggal Kabupaten Deli Serdang
Authors: Ginting Louisa Novrianta , Kadir Abdul , Angelia Nina
Published: March 2024

The village head acts as a leader and must have an attitude of initiative, provide solutions that can improve performance, provide direction and input that can support in carrying out the activities or tasks given. As for the problem formulation, what is the leadership role of the Village Head in Improving Performance at the Sukamaju Village Office, Sunggal Subdistrict, Deli Serdang Regency and what factors are hindering the performance of the Village Head in the Sukamaju Village Office, Sunggal District, Deli Serdang Regency. The research method used was a qualitative approach and data collection techniques used were library observation, interviews and documentation. Based on the results of the research, the leadership role of the Village Head in Improving Performance at the Sukamaju Village Office, Sunggal Subdistrict, Deli Serdang Regency by providing guidance, supervision, exemplary and motivation has generally been running quite well, but improvements must continue. The factors hindering the performance of the Village Head at the Sukamaju Village Office, Sunggal Subdistrict, Deli Serdang Regency are still lacking in leadership such as lack of objective in providing assessments of the work and assignment given, Lack of leadership skills or spirit and lack of leadership knowledge.
Peran Masyarakat Dalam Pembangunan Desa Di Desa Purba Dolok Kecamatan Doloksanggul Kabupaten Humbang Hasundutan
Authors: Purba Januarny , Nasution Irwan , Kurniaty Evi Yunita
Published: March 2024

The role of the community in development is still relatively passive, this can be seen from some people who do not care about the village development that will be carried out. The purpose of this study is to find out the role of the community in development and to find out the obstacles to the role of the community in village development in the village of Purba Dolok. In this study, the type of research carried out by the author is a qualitative descriptive approach method, which explains the problems that exist in the form of words and writing in every existing event. Indicators of the role of the Purba Dolok village community as a policy role, in the form of arguments such as building placement, paying attention to building durability and building maintenance. Then, the role as a strategy where the community cooperates with village officials in developing strategies for the implementation of development in the form of site preparation, adjustment of budget funds and the formation of working groups. The role as communication, in this case, the communication of the village community and village officials provide information to the community through the head of the hamlet who is responsible for the environment of each hamlet. The role as a dispute resolution tool, in this case the way that is carried out in reducing differences of opinion and conflicts that arise, the holding of village deliberations for voting in order to overcome differences of opinion that arise when village deliberations are held.
Peranan Pemerintah Desa dalam Meningkatkan Penerimaan Pajak Bumi dan Bangunan di Desa Pagaran Lambung III Kabupaten Tapanuli Utara
Authors: Sipahutar Netrianni , Wulandari Novita , Lubis Yurial Arief
Published: March 2024

The low land and building tax receipts in Pagaran Lambung III village need to be strengthened by the role of the village government in this case apparatus and institutional resources. This study aims to identify and describe the role of the village government in increasing land and building tax revenues. Through the role of a good village government and complete village head office facilities, which can support the administration of tax payments, it can increase land and building tax revenue and community participation in Pagaran Lambung III village, which is one of the sources of local revenue (PAD) of North Tapanuli district. The inhibiting factors are the low level of the people's economy, the low level of public tax knowledge and the payment system which is still manual. In solving the problems that occur researchers use the role theory put forward by Ryaas Rasyid. This type of research uses a qualitative approach descriptive method. Data sources were collected based on data collection techniques, namely observation, interviews and documentation. As a reinforcement of this study, it consisted of key informants, main informants and additional informants. The research results obtained are that the role of the village government has not optimally carried out its functions and obligations in providing guidance or direction in solving land and building tax revenue problems that have not reached the tax realization target set by the North Tapanuli district government.
Analisis Kinerja Aparatur Pemerintahan Dalam Penyaluran Program Keluarga Harapan (PKH) Pada Masyarakat Miskin Di Kelurahan Kenangan Baru Kecamatan Percut Sei Tuan Kabupaten Deli Serdang
Authors: Hutabarat Anjuyto , Lubis Yurial Arief , Suharyanto Agung
Published: March 2024

The Family Hope Program (PKH) is a conditional cash transfer targeting Very Poor Families (KSM) with the aim of alleviating poverty. This article aims to analyze the performance of government officials in distributing PKH to the poor in Kenangan Baru Village and to find out what are the inhibiting factors in distributing PKH in the Village. The problem in this research is focused on the less than optimal distribution of PKH aid funds and also the target of receiving PKH assistance that has not been realized properly. In order to approach this problem, the theoretical reference from Mondy, Noe and Premeaux regarding performance measurement includes Quantity, Quality, Independence, Initiative, Adaptation, Cooperation. The data collected is based on data collection techniques through observation, interviews, and documentation. Then analyzed using a descriptive qualitative method. This study concludes that the quantity of work; PKH distribution has been carried out well, Quality of work; not yet precise target and timing of distribution of funds, the independence of the apparatus; have not been able to work with minimal help from others, Initiative; in response to data problems PKH companions visited KPM homes, Adaptation; PKH assistants adapt well to KPM in monthly activities, Cooperation; lack of coordination between assistants and apparatus in the Kelurahan. Obstacles in PKH distribution are not synchronized KPM data, lack of KPM participation in monthly activities, limited companion human resources, and undisbursed aid funds.
Marcos Arana Cervantes, el adiós a una figura imprescindible en la historia de la radio informativa de Jalisco
Authors: Velasco Sergio
Published: March 2024

El 6 de julio de 2021 murió Marcos Arana Cervantes. Sin duda, una de las figuras más destacadas del periodismo radiofónico en la historia de Jalisco. Fue reportero, editor, conductor y director de informativos por más de cincuenta años en Inforjal, Notisistema, Triple A, Radio Red, Promomedios y Canal 58. Esta trayectoria lo convirtió en un referente de la noticia en el occidente de México.
José Hernández Claire, una vida en blanco y negro
Authors: de Alba Robles María Teresa
Published: March 2024

Las fotografías de José Hernández Claire son autorretratos, son espejos que reflejan sus intereses y experiencias. En su obra demostró sus inquietudes e inclinaciones a través de tres temas principales: religión, migración y calle. Sus fotografías fueron denuncias de situaciones terribles pero reales.
Alcances y retos del monitoreo a los medios en campañas electorales: una mirada desde la prensa local
Authors: Ramírez García Zaira Yael
Published: March 2024

Los excesos por parte de los partidos políticos y los candidatos durante los procesos electorales han provocado una sobrerregulación en las leyes en materia electoral: lo relacionado con los gastos de los recursos públicos y privados, medidas en materia de transparencia, rendición de cuentas y también en lo que se refiere a los tiempos y espacios que se destinan en los medios de comunicación para quienes aspiran a ocupar cargos públicos.
Presentación. 2020: el año de la pandemia
Authors: Larrosa–Fuentes Juan S.
Published: March 2024

Resulta imposible, o al menos muy difícil, imaginar el texto introductorio de un informe anual que glosa lo ocurrido en 2020 y que no comience recordando que fue el año de la pandemia. Aunque el virus del sars-CoV–2 comenzó a dispersarse hacia finales de 2019, la pandemia causada por covid–19 tomó fuerza en 2020. Esta contingencia sanitaria obligó a muchos países del mundo a hacer paros totales de actividades y largas cuarentenas, aceleró los procesos digitales en ámbitos políticos, económicos y culturales, provocó crisis económicas nunca vistas en los últimos cien años y, sobre todo, causó la muerte de millones de personas.
Transparencia y covid–19 en Jalisco
Authors: Bautista Farías José
Published: March 2024

Entre los estudios de la rendición de cuentas, la transparencia y el derecho a la información existe consenso de que estos conceptos constituyen elementos centrales de una democracia y son herramientas que favorecen el diálogo y la comunicación entre el gobierno y los ciudadanos. En el presente artículo se aludirá a la transparencia entendida “como la divulgación de la información que producen las organizaciones públicas y que es útil para monitorear y evaluar las acciones/decisiones de los gobiernos”.
ЖАНРОВА БАГАТОГРАННІСТЬ ПРОЧИТАННЯ ОБРАЗУ МІКЕЛАНДЖЕЛО: ДРАМАТУРГІЙНЕ (Г. ЛОНГФЕЛЛО), ЕСЕЇСТСЬКЕ (Р. РОЛЛАН), ПОЕТИЧНЕ (Е. ВЕРГАРН)
Authors: Кравець Ярема
Published: March 2024

У статті розглядаються окремі факти різножанрового прочитання образу визначного художника, скульптора і поета часів Відродження Мікеланджело Буонаротті (1475-1564) класиками трьох національних літератур – Г. Лонгфелло, Р. Ролланом, Е. Вергарном. 

Метою статті є висвітлення неординарного прочитання та наукової інтерпретації величного мистецького і громадянського подвигу велетня Відродження через акцентування на підставових проблемах його творчого життя. 

Дослідницька  методика. У статті використовується системний підхід із застосуванням історико-літературознавчого, генетичного та порівняльного методів. На основі цих методів з’ясовано історію зацікавлення творчістю Мікеланджело драматургійним, есеїстським та поетичним прочитанням у трьох національних літературах.  

Результати. У дослідженні подані факти інтерпретації чільніших епізодів жертовної праці італійського скульптора, що досі не залучалися до наукового трактування в українських літературознавчих студіях. Йдеться також і про окремі сцени, трактування важливіших політичних подій, пов’язаних із життям Мікеланджело. 

Наукова новизна. Стаття є цікавою сторінкою входження творчості італійського мистця в українські компаративістичні дослідження. Вартісною є презентація промовистих фактів зацікавлення харизматичною діяльністю Мікеланджело через її різножанрове прочитання американською, французькою та французькомовною бельгійською літературами. 

Практична  вартість. Стаття може стати підґрунтям для глибшого пізнання спадщини видатних класиків трьох національних літератур, тих елементів, які продукують авторські стильові домінанти.
Eating at Risk within Long-Term Care: A Case for the Relational Ethics Lens
Authors: Sandhu Rebekah , Brown Meara , Webber Jodi
Published: March 2024

Within long-term care homes (LTCHs), conflicts occur between residents’ desires, LTCH constraints, and healthcare providers’ concerns about risks of harm. Due to the high prevalence of dysphagia and malnutrition in these settings, decisions regarding food choices are a common source of such tensions. Existing biomedical ethical models fail to capture the complexity of the interprofessional chronic care environment. This article proposes an alternative ethical lens, the relational ethics model. We describe a case illustrating the application of a decision-making framework with a relational ethics lens for a resident with severe dysphagia and malnutrition. We highlight how the bioethics model excludes important actors from ethical decision making. We encourage registered dietitians working in LTCH to incorporate a relational ethics model into their practice to help identify resident’s values and bring attention to the interconnectedness of caring relationships and contextual factors. This approach can inform difficult decisions regarding the food and nutrition choices of residents and may facilitate meaningful outcomes for both individuals and the long-term care community.
The possibilities of using riddles in working with older preschool children with mental retardation (message 2)
Authors: Kovalenko Oksana Mikhailovna , Brovina Oksana Sergeevna
Published: March 2024

The article presents data showing the possibilities of using riddles in working with children aged 6-7 years with mental retardation in preparation for the plot-role-playing game "In the store".
RELATIVE METRIC INDICATORS OF THE UPPER AND LOWER PARTS OF THE INTERNAL NASAL VALVE LUMEN AND THEIR IMPACT ON NASAL RESPIRATORY AND OLFACTORY FUNCTIONS
Authors: Shkorbotun Volodymyr O. , Ovsiienko Maksym O. , Shkorbotun Yaroslav V.
Published: March 2024

The aim of the article: To study the influence of absolute and relative metric indicators of the lumen of certain parts of the internal nasal valve on the effectiveness of olfactory and respiratory functions of the nasal cavity.
Materials and methods: A comparison of the metric values of the internal nasal valve, air resistance and odor perception in 32 patients after septoplasty was performed, depending on the quality of life and complaints according to SNOT 22. Group 1 consisted of 22 patients who complained of subjective feelings of nasal insufficiency (SNOT 22 – 9-20 scores). Control group consisted of 10 patients who were satisfied with septoplasty results (SNOT 22 – 0-7 scores). Rhinomanometry was performed according to the PARM method, olfactometry was carried out using the Sniffin’ Sticks psychophysical tests, and planimetry on CT was performed in the RadiAnt DICOM Viewer 2022.1 program, using the closed polygon tool.
Results: Significant differences in the relative values of the ratio of the upper part of the valve area to the lower part were observed between the two groups of patients. A significant difference in better odor perception was noted in group 2. It was 0.7±0.02 in patients of the control group, and 0.4±0.02 in patients of Group 1. Air resistance in the nasal cavity during unilateral rhinomanometry did not significantly differ (0.28±0.04 and 0.26±0.07 Pa/cm3/sec). The average score during olfactometry in patients of the control group was 11.4±0.13, in patients of Group 1 it was 8.8±0.2, which indicates the presence of hyposmia (p>0.05).
Conclusions: The ratio of the areas of the upper and lower parts of the internal nasal valve does not affect the overall airway resistance in the nose, but it can disrupt the distribution of air between the nasal passages. When evaluating the results of septoplasty, in particular, if the patient is not satisfied with nasal breathing, it is important to pay attention to the ventilation of the upper parts of the nasal cavity. One of the markers of its impairment may be hyposmia.
DYNAMICS OF THE LEVELS OF ASYMMETRIC DIMETHYLARGININE AND PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1 IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION AND TYPE 2 DIABETES MELLITUS DEPENDING ON THE REPERFUSION STRATEGY
Authors: Minukhina Diana V. , Kravchun Pavlo G. , Minukhin Dmitriy V. , Yevtushenko Denis A. , Kritsak Vasyl V. , Tkachenko Volodymyr V.
Published: March 2024

Introduction. Despite the major successes achieved in the treatment of acute coronary syndromes (ACS), acute myocardial infarction (AMI) remains the main cause of death among the working-age population of Ukraine. The means of treatment of interventional cardiology can actually reduce the mortality of patients with ACS, improve the course of the acute period of the disease and ensure less reduction in the functional capabilities of the heart in the future. Among the many pathogenetic mechanisms of vascular inflammation in coronary heart disease and type 2 diabetes, endothelial dysfunction is the determining factor.
The aim of the study. To evaluate the levels of plasminogen activator inhibitor type 1, asymmetric dimethylarginine and endothelial nitric oxide synthase on the 10-14th day in patients depending on the presence or absence of concomitant diabetes type 2 and the type of reperfusion therapy.
Materials and methods. 130 patients with acute myocardial infarction were examined, who were divided into 2 groups: 1 group consisted of patients with acute myocardial infarction with accompanying type 2 diabetes (n=73), 2 group – patients with acute myocardial infarction without type 2 diabetes (n =57). The quantitative content of the plasminogen activator inhibitor type 1 (PAI-1) was determined by the immunoenzymatic method using a commercial test system manufactured by Technoclone PAI-1 ELISA Kit (Austria), endothelial nitric oxide synthase (NOS) – Enzyme-Linked Immunosorbent Assay (ELISA) Kit For Nitric Oxide Synthase Endothelial, asymmetric dimethylarginine (ADMA) – Immunodiagnostik ADMA ELISA Kit (Austria).
Results. Percutaneous coronary intervention (PCI) contributes to a more significant decrease in the content of the marker of endothelial dysfunction – ADMA and an increase in NOS on the 10-14th day of acute myocardial infarction in comparison with standard therapy. During PCI, the level of PAI-1 did not reliably change during treatment due to post-inflammatory and post-traumatic activation of platelets in the vascular wall.
Conclusions. In patients with acute myocardial infarction with type 2 diabetes mellitus, percutaneous coronary intervention contributes to a significant decrease in the content of asymmetric dimethylarginine and an increase in NOS on the 10-14th day of acute myocardial infarction, but was not accompanied by a significant decrease in the level of PAI-1, which in general indicates positive effect of performed myocardial revascularization.
RADIOLOGICAL FEATURES OF THE LOCATION OF CYSTIC FORMATIONS IN THE MAXILLARY SINUS AND THEIR RELATIONSHIP WITH ALVEOLAR BONE PATHOLOGY OF THE UPPER JAW
Authors: Shkorbotun Volodymyr O. , Nachesa Yaroslav S. , Shkorbotun Yaroslav V.
Published: March 2024

The aim of the study. To study the features of the location of cystic formations in the maxillary sinus based on CT scans and to determine their relationship with the pathology of the upper jaw teeth.
Materials and methods. The study involved the analysis of 552 head computed tomography scans of patients referred for examination by an otolaryngologist or dentist. The total number of individuals examined was 552, comprising 44.7% females and 55.3% males, aged 18-74 years. The investigation was conducted using the NewTom GO device with a measurement range of 155-172 mGy/cm±10%, with an error of ±4.24%. Statistical processing of data was carried out using the STATISTICA v.12.6 software.
Results. Out of 552 computed tomography images analyzed, 92 images of individual maxillary sinuses (MS) of 79 patients with single cysts were selected. They were divided into two groups. Group 1 involved patients with cysts on the lower wall of MS (n=76). Group 2 included patients with cysts on other walls (n=16). The assessment of the ratio of 4, 5, 6, 7 tooth roots of the upper jaw to the lower wall of the upper jaw showed that the protrusion frequency in Group 1 was significantly higher (42.1%) compared to Group 2 (18.7%). Meanwhile, the average thickness of the bone over these teeth in Group 2 was significantly greater (3.4 ± 1.09 mm) than in Group 1 (1.9 ± 0.92 mm) (p=0.0003). In both patient groups, the greatest thickness was observed over tooth 4, and the smallest over tooth 7. Additionally, in 33.7% of cases, the cyst was associated with involvement of deep structures of the projecting teeth and the spread of inflammation to the lower wall of MS.
Conclusions. Among patients referred by an otolaryngologist or dentist for CT examination to radiologically verify pathological processes in the nasal cavity, paranasal sinuses, and the upper jaw teeth, MS cysts were detected in 19.6% of cases, with 83% of them being localized in its lower parts. In patients with cysts located in the lower parts of MS, the roots protruding into the sinus cavity and a thinner layer of bone over them are more frequently observed compared to those where cysts are located in other areas of MS. In patients with cystic formations in the alveolar recess of MS, radiological signs of pathology of the upper jaw teeth are detected in 34% of cases.
POPULATION'S RADIATION ANXIETY STRUCTURE ANALYSIS FOR THE PRE-COVID-19 PERIOD
Authors: Dorohań Sehrii B. , Shevchenko Oleksandr A. , Lekhan Valeria M. , Sheviakov Oleksiy V. , Operchuk Nadia I. , Mikryukova Natalya G. , Cherednichenko Oleksiy M.
Published: March 2024

Introduction. A considerable amount of conflicting reports creates conditions for concern about the effects of radiation on health. The adequacy of the assessment of problems and responses to these challenges depends on the sources used by a person, his culture and education level, as well as the emotional overtone of this assessment.
The aim of the study is to determine dynamic changes in the prevalence and structure of population’s radiation anxiety states under stable social conditions based on a psychological and hygienic assessment.
Materials and methods: In order to research and assess the perception of Kropyvnytskyi residents about the degree and prevalence of radiation anxiety states, a survey was conducted on Facebook and Instagram social networks from February to December 2019 using Google Form. For assessment of dynamic changes in radiation anxiety, data from our own studies in 2014 were used [9]. The questionnaire methodology was based on the principles of the previously tested and patented "Methodology for determining radiation anxiety among the population" and the monograph "Radiation anxiety among the population". Three hundred and twenty four residents of Kropyvnytskyi aged 18 to 73 were included in the study, 155 (47.8%) men and 169 (52.2%) women. The average age of the interviewees (Me (LQ; HQ)) was 27 (20; 33) years old.
Results. A specific psycho-emotional state is developed and maintained at some level in the residents of cities with nuclear power plants – radiation anxiety, which is manifested by a complex of neuropsychological and somato-physiological disorders against the fear of ionizing radiation sources background. At the same time, such a psychogenic effect may not be related to the degree of actual effects of ionizing radiation on human health. It was determined that in 2019, before the COVID-19 pandemic and Russia's full armed aggression against Ukraine, more than 90% of the surveyed residents of Kropyvnytskyi, regardless of gender and age, were concerned about potential radiation pollution of the environment and foodstuffs, medium level of radiation anxiety was in 34,9%, and high level in 14.8% . Low radiation anxiety was detected in 41.4% of respondents, and in 8.9% it was absent.
Conclusions. Over 5 years (from 2014 to 2019), there were noticeable negative changes in the structure of the radiation anxiety states among the surveyed urban residents, namely: the amount of people without signs of radiation anxiety halved (8.9% vs. 16.0%) and respondents with the high level of this psycho-emotional state increased almost four times (14.8% versus 3.9%). The obtained results encourage the authors to future studies of specific radiation anxiety states among the population to clarify their dynamics.
INVOLVEMENT OF DIFFERENT STAKEHOLDER GROUPS IN ENSURING CHILDREN’S DENTAL PUBLIC HEALTH: ANALYSIS AND PERSPECTIVES
Authors: Kriachkova Lilia V. , Korobko Mykhailo Y.
Published: March 2024

Introduction: Strengthening the dental public health (DPH) of the pediatric population requires prioritizing development with the identification of key stakeholders and their leading functions.
The aim. To analyze the current state and identify prospects for intra-industry and inter-sectoral cooperation in the process of strengthening the dental public health of the child population to justify ways of optimization.
Materials and methods. A cross-sectional study using expert assessments involving 15 highly competent experts (competence level above 0.85) was conducted through a specially designed program. Bibliosemantic and sociological methods were employed. Expert assessments and stakeholder mapping were performed, visualizing the «authority-interest» relationship of different interested groups on a two-dimensional model. The results were analyzed using standard statistical methods with the application of Jupyter Notebook (https://jupyter.org/install). Intra-class correlation coefficients were used to assess the agreement of expert opinions. A significance level of p<0.05 was considered critical in testing all statistical hypotheses.
Results. The graphical analysis allowed for the identification of stakeholders and determination of their roles in the DPH system. Groups with high and low levels of power and interest were identified. The agreement among experts regarding the determination of power and interest was respectively ICC=0.76 (95% CI 0.56 – 0.91) and ICC=0.79 (95% CI 0.59 – 0.92). The necessity of targeted efforts with each group, considering their capabilities and limitations, was emphasized. Key stakeholders included families, communities, family physicians, public health institutions, pediatric dentists, and others. Primary functions aimed at strengthening children’s dental health were attributed to influencing determinants of dental health, intersectoral collaboration and support for relevant initiatives at the local level are essential.
Conclusions. The importance of developing and implementing programs aimed at improving the dental health of the child population has been established. Emphasis is placed on the significance of collaboration among various stakeholders in supporting a strategic approach to managing DPH.
MULTIMODAL ANESTHESIA AS AN IMPORTANT COMPONENT OF ERAS
Authors: Chernii Volodymyr I.
Published: March 2024

Introduction. The ideology of Fast Track-Surgery (FTS) and Enhanced Recovery After Surgery (ERAS) represents modern trends in global surgical practice. Anesthesiology aims to provide ideal and universal solutions for protecting patients from surgical aggression. A multimodal approach, which includes multilevel, multifaceted antinociception, is well-founded, where maximum effectiveness is combined with minimal side effects.
The aim. To analyze the issue of multimodal pain management as an important component of ERAS (Enhanced Recovery After Surgery) from modern sources of literature for optimizing perioperative care in the minimally invasive surgery department.
Materials and methods. Bibliosemantic, comparative, and systemic analysis methods were employed. The proposed recommendations were developed based on an analysis of modern literature, the results of randomized trials and meta-analyses, as well as our own studies dedicated to the study of perioperative pain issues.
The results. It has been proven that the use of opioids in anesthesia practice is decreasing. New and modern methods of continuous monitoring of vital organs in patients are being introduced as supplements to classical monitoring protocols. These methods are used to avoid excessive or inadequate dosing of anesthetics, adjust the concentration of substances used, reduce post-anesthesia complications, and improve patient comfort. The method of perioperative energy monitoring significantly complements the "International Standards for Safe Anesthetic Practice", WFSA (2010), and enhances perioperative patient safety by detecting metabolic disturbances and implementing appropriate pathogenetic correction. The importance of regional anesthesia under ultrasound control, nociception-antinociception balance management, and the impact of these methods on opioid consumption, patient satisfaction, and postoperative recovery have been proven.
Conclusions. The most commonly used combination of drugs for multimodal analgesia often includes acetaminophen and NSAIDs (strong recommendation). It has been proven that deep and prolonged sedation in intensive care unit (ICU) patients is associated with worse outcomes, longer mechanical ventilation duration, extended ICU and hospital stays, and higher rates of complications, including infections and sometimes even death.
Looking at GDP from a Statistical Perspective: Spatio-Temporal GSTAR(1;1) Model
Authors: Huda Nur'ainul Miftahul , Imro'ah Nurfitri , Arini Nani Fitria , Utami Dewi Setyo , Umairah Tarisa
Published: March 2024

The gross domestic product (GDP) is a significant indicator for evaluating the performance of an economy. The GDP of a nation can be used to get a sense of the size and health of that nation's economy. Indonesia is the only nation from Southeast Asia to be represented in the G20. All G20’s countries play vital roles in creating the economic landscape of the region, the world, and everything in between. This research is focused on the increase of the GDP in Indonesia, Malaysia, Singapore, Thailand, and Brunei Darussalam. The spatial influence of GDP can be seen in the growth of each nation's infrastructure and industrial sector, for example. at the regional level, the increase of a country's GDP can also have an effect on the countries that are its neighbors. Using the GSTAR model, the aim of this study is to investigate the spatial and temporal influences on the GDP statistics of five different countries. The GSTAR model is distinguished by the presence of a weight matrix, which is one of its distinguishing features. In addition, the aim of this research is to select the most appropriate weight matrix for the purpose of representing the spatial effect on GDP statistics. Uniform, queen contiguity, and inverse distance weight matrices are the types of weight matrices that are utilized. Calculating each weight matrix, estimating relevant parameters, and performing diagnostic tests are the primary activities involved in this investigation. As a consequence of this, a weight matrix that is uniform in its distribution is the one that performs the best. The spatial and temporal correlations of GDP data may be accurately represented by the GSTAR model when it is equipped with a uniform weight matrix. This model is applied to five different countries.
Numerical Solution of the Advection-Diffusion Equation Using the Radial Basis Function
Authors: Sabran La Ode , Syafi'i Mohamad
Published: March 2024

The advection-diffusion equation is a form of partial differential equation. This equation is also known as the transport equation. The purpose of this research is to approximatio the solution of advection-diffusion equation  by numerical approach using radial basis functions network. The approximation is performed by using the multiquadrics basis function. The simulation of the numerical solution is run with the help of the Matlab program. The one-dimensional advection-diffusion equation used is  ∂u/∂t+C ∂u/∂x=D (∂^2 u)/(∂x^2 )  with given initial conditions, boundary conditions, and exact solution u(x,t). The numerical solution approximation using the radial basis function network with dt=0.004 and dx=0.02 produces the value at each discretization point is close to the exact solution. In this study, the smallest error between numerical solution and the exact solution is obtained 2.18339 ×〖10〗^(-10).