bluuebunny/crossref_metadata_2025 huggingface dataset:
Boosting the Acidic Oxygen Reduction Activity of p‐Block Single‐Atomic Catalyst via p–p Orbital Coupling and Pore Engineering
Authors: Wang Hu , Zhao Yongjian , Li Jun , Wang Xiaosha , Huang Murong , Zhang Lei , Zhao Chenyang
Published: April 2023

Atomically dispersed main group element single‐atom catalysts (SACs) have recently attracted increasing attention in electrocatalysis. However, their performances in acidic oxygen reduction reaction (ORR) remain unsatisfactory owing to the suboptimal coordination environment, limited mass transfer, and active site exposure. Herein, a series of p‐block Sn SACs with hierarchical pore structures are prepared by a dual melting salt‐mediated soft template method. By deliberately regulating the pore structures, highly exposed Sn active sites with N/O coordination are obtained, which endow SnN3O‐50 with exceptional ORR performances, especially in acidic medium. The half‐wave potential of SnN3O‐50 is up to 0.816 V, with a loss of only 15 mV after 10 000 potential cycles. Furthermore, the peak power densities of the fuel cell and zinc–air battery assembled using SnN3O‐50 as cathodes reach 502 and 173.5 mW cm−2, respectively, demonstrating great potential for practical applications. Density functional theory (DFT) calculations reveal that the N/O coordination of Sn induces localization of 5p electrons, which leads to strong coupling with the p orbit of O2. Meanwhile, the presence of defects synergistically regulates the adsorption of reaction intermediates, thereby optimizing the free energy of the four successive ORR steps.
The Emergence and Properties of Selectively Fluorinated ‘Janus’ Cyclohexanes
Authors: O'Hagan David
Published: April 2023

This account describes the evolution of a research programme that started by linking fluoromethylene (−CHF−) groups along aliphatic chains and then progressing to alicyclic rings with contiguous fluorine atoms. Different stereoisomers of aliphatic chains tend to adopt low polarity conformations. In order to force polar conformations, the programme began to address ring systems and in particular cyclohexanes, to restrain conformational freedom and co‐aligned C−F bonds. The flagship molecule, all‐cis‐1,2,3,4,5,6‐hexafluorocyclohexane 7, emerged to be the most polar aliphatic compound recorded. The polarity arises because there are three co‐aligned triaxial C−F bonds and the six fluorines occupy one face of the ring. Conversely the electropositive hydrogens occupy the other face. These have been termed Janus face cyclohexanes after the Roman god with two faces. The review outlines progress by our group and others in preparing derivatives of the parent cyclohexane 7, in order to explore properties and potential applications of these Janus cyclohexanes.
Reactions Using Freons and Halothane as Halofluoroalkyl/Halofluoroalkenyl Building Blocks
Authors: Karuo Yukiko , Tarui Atushi , Sato Kazuyuki , Kawai Kentaro , Omote Masaaki
Published: April 2023

In recent years, hydrofluorocarbon compounds such as chlorofluorocarbons, hydrochlorofluorocarbons, and 2‐bromo‐2‐chloro‐1,1,1‐trifluoroethane (halothane) have been used as fluorine‐containing building blocks to construct functional fluorine‐containing compounds, e. g., polymers, liquid crystals, and medicines. Hydrofluorocarbons promote the formation of reactive fluoroalkyl or fluoroalkenyl species via anionic or radical processes, and these species can act as nucleophiles or electrophiles depending on the reaction conditions. Progress in fluorine chemistry using hydrofluorocarbons in the last 30 years is described in this review and diverse reactions are discussed, including the fluoroalkyl/alkenyl products and proposed mechanisms involved.
Visible‐Light Promoted Radical Fluoroalkylation of O‐ and N‐Substituted Alkenes
Authors: Levin Vitalij V. , Dilman Alexander D.
Published: April 2023

Interaction of enol ethers enol acetates, enamides and enamines with fluorinated reagents may be considered as a reliable method for the synthesis of organofluorine compounds. While classic nucleophile/electrophile substitution or addition mechanisms cannot be realized for coupling of these components, their intrinsic reactivities are revealed with the aid of photoredox catalysis. A combination of these electron donating and accepting components provides a perfect balance needed for individual redox steps, which in some cases may proceed even without a photocatalyst. The same electronic factors also support the key C,C‐bond forming event involving addition of fluorinated radical at the electron rich double bond.
Forced Convection during Cooling of Power Supply Box using Pulsation Flow with Piezoelectric Fan
Authors: Abdelouahab Bouttout
Published: April 2023

Forced convection flow of air through power supply box with piezoelectric fan of nine identical electrical devices has been numerically investigated. This work simulates a practical situation in which periodic temperature is generated in an electrical device as a result of its periodic input voltage. The finite volume method has been adopted to solve the governing equations. The effects of important parameters such as pulsation flow frequencies and temperature modulation frequency on heat transfer rates were investigated in details for Re = 500 corresponding to velocity of 0.39 m/s. The piezoelectric vibration amplitude is fixed at 0.2 and frequencies are varied in the range of [0–3] corresponding to [0–287] Hz. We have found that the time averaged Nusselt number for each electrical device depends on the pulsation frequency and heat modulation, and it is always larger than that in the steady‐state case. The results show that there exists a short band of frequencies which the enhancement of heat transfer of all electrical devices is higher than 55% compared with that of steady state. In addition, the heat transfer is maximum when heated pulsation frequency in the device is set as St = 3.0 corresponding to frequency of 58.5 Hz of input voltage. The combined pulsation flow by piezoelectric fan and heated pulsation by input voltage show vigorous heat transfer through electrical devices blocks and the heat transfer enhancement was observed in relatively narrow bands of frequencies. The efficiency of piezoelectric fan is expressed by the maximum temperature of the ninth electrical device which not exceed 80°C for time‐averaged velocity of 0.556 m/s and vibration frequency of 34.75 Hz of piezoelectric fan. The pressure drop and power pumping of piezoelectric fan are obtained for different Reynolds numbers. We found that the power loss was 4.6 times higher than for the piezoelectric fan at Re = 500. Good agreement between our numerical simulations of piezoelectric fan and experimental results available from the literature is obtained. © 2023 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Classical double copy of spinning worldline quantum field theory
Authors: Comberiati Francesco , Shi Canxin
Published: April 2023

Abstract

We study the classical double copy of massive spinning objects in the worldline quantum field theories (WQFT) formalism. We couple the $$ \mathcal{N} $$
N
= 1 supersymmetric model to a Yang-Mills background to describe the propagation of a spin-half particle interacting with gluons. At the classical level, this model captures physical effects up to linear order in spin. We propose a double copy relation to map the spin tensors to the gravitation side. Enforcing R-symmetry and supersymmetry (SUSY) on the double copy integrands, we find that the gravitational theory is the $$ \mathcal{N} $$
N
= 2 particle coupled to dilaton-gravity (DG). We check the double copy prescription for the eikonal phase up to next-to-leading order and for radiation at leading order in coupling constants, finding that the Grassmann nature of the spin tensor in WQFT plays a crucial role in finding full agreement with direct calculation in the $$ \mathcal{N} $$
N
= 2 model. We show how to deform the SUSY charges of the free theory to include DG. Since the constraints algebra is first class, the worldline model can be quantized, describing the propagation of a massive vector field coupled to DG, in agreement with the literature. In addition, we investigate the double copy without preserving SUSY and R-symmetry, finding that the B-field also couples to the worldline.
Narain CFTs and quantum codes at higher genus
Authors: Henriksson Johan , Kakkar Ashish , McPeak Brian
Published: April 2023

Abstract

Code CFTs are 2d conformal field theories defined by error-correcting codes. Recently, Dymarsky and Shapere generalized the construction of code CFTs to include quantum error-correcting codes. In this paper, we explore this connection at higher genus. We prove that the higher-genus partition functions take the form of polynomials of higher-weight theta functions, and that the higher-genus modular group acts as simple linear transformations on these polynomials. We explain how to solve the modular constraints explicitly, which we do for genus 2. The result is that modular invariance at genus 1 and genus 2 is much more constraining than genus 1 alone. This allows us to drastically reduce the space of possible code CFTs. We also consider a number of examples of “isospectral theories” — CFTs with the same genus 1 partition function — and we find that they have different genus 2 partition functions. Finally, we make connection to some 2d CFTs known from the modular bootstrap. The n = 4 theory conjectured to have the largest possible gap in Virasoro characters, the SO(8) WZW model, is a code CFT, allowing us to give an expression for its genus 2 partition function. We also find some other known CFTs which are not code theories but whose partition functions satisfy the same simple polynomial ansatz as the code theories. This leads us to speculate about the usefulness of the code polynomial form beyond the study of code CFTs.
Two-loop helicity amplitudes for H+jet production to higher orders in the dimensional regulator
Authors: Gehrmann Thomas , Jakubčík Petr , Mella Cesare Carlo , Syrrakos Nikolaos , Tancredi Lorenzo
Published: April 2023

Abstract

In view of the forthcoming High-Luminosity phase of the LHC, next-to-next-to-next-to-leading (N3LO) calculations for the most phenomenologically relevant processes become necessary. In this work, we take the first step towards this goal for H+jet production by computing the one- and two-loop helicity amplitudes for the two contributing processes, H → ggg, $$ H\to q\overline{q}g $$
H
→
q

q
¯

g
, in an effective theory with infinite top quark mass, to higher orders in the dimensional regulator. We decompose the amplitude in scalar form factors related to the helicity amplitudes and in a new basis of tensorial structures. The form factors receive contributions from Feynman integrals which were reduced to a novel canonical basis of master integrals. We derive and solve a set of differential equations for these integrals in terms of Multiple Polylogarithms (MPLs) of two variables up to transcendental weight six.
Proteome alterations in human autopsy tissues in relation to time after death
Authors: Kocsmár Éva , Schmid Marlene , Cosenza-Contreras Miguel , Kocsmár Ildikó , Föll Melanie , Krey Leah , Barta Bálint András , Rácz Gergely , Kiss András , Werner Martin , Schilling Oliver , Lotz Gábor , Bronsert Peter
Published: April 2023

Protein expression is a primary area of interest for routine histological diagnostics and tissue-based research projects, but the limitations of its post-mortem applicability remain largely unclear. On the other hand, tissue specimens obtained during autopsies can provide unique insight into advanced disease states, especially in cancer research. Therefore, we aimed to identify the maximum post-mortem interval (PMI) which is still suitable for characterizing protein expression patterns, to explore organ-specific differences in protein degradation, and to investigate whether certain proteins follow specific degradation kinetics. Therefore, the proteome of human tissue samples obtained during routine autopsies of deceased patients with accurate PMI (6, 12, 18, 24, 48, 72, 96 h) and without specific diseases that significantly affect tissue preservation, from lungs, kidneys and livers, was analyzed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). For the kidney and liver, significant protein degradation became apparent at 48 h. For the lung, the proteome composition was rather static for up to 48 h and substantial protein degradation was detected only at 72 h suggesting that degradation kinetics appear to be organ specific. More detailed analyses suggested that proteins with similar post-mortem kinetics are not primarily shared in their biological functions. The overrepresentation of protein families with analogous structural motifs in the kidney indicates that structural features may be a common factor in determining similar postmortem stability. Our study demonstrates that a longer post-mortem period may have a significant impact on proteome composition, but sampling within 24 h may be appropriate, as degradation is within acceptable limits even in organs with faster autolysis.
Total knee arthroplasty without patella resurfacing leads to worse results in patients with patellafemoral osteoarthritis Iwano Stages 3–4: a study based on arthroplasty registry data
Authors: Nardelli Paul , Neururer Sabrina , Gruber Kerstin , Wippel David , Kogler Nadine , Ender Sebastian , Leitner Hermann , Koller Benedikt , Fischer Martin , Dammerer Dietmar , Liebensteiner Michael
Published: April 2023

Purpose

To determine whether the preoperative degree of degeneration of the patellofemoral joint really affects the outcome of total knee arthroplasty (TKA) surgery without patella resurfacing and thus to establish a parameter that might serve as a guiding factor to decide whether or not to perform retropatellar resurfacing. It was hypothesized that patients with preoperative mild patellofemoral osteoarthritis (Iwano Stages 0–2) would significantly differ from patients with preoperative severe patellofemoral osteoarthritis (Iwano Stages 3–4) in terms of patient-reported outcome (Hypothesis 1) and revision rates/survival (Hypothesis 2) after TKA without patella resurfacing.

Methods

Application of a retrospective–comparative design on the basis of Arthroplasty Registry data that included patients with primary TKA without patella resurfacing. Patients were allocated to the following groups based on preoperative radiographic stage of patellofemoral joint degeneration: (a) mild patellofemoral osteoarthritis (Iwano Stage ≤ 2) and (b) severe patellofemoral osteoarthritis (Iwano Stages 3–4). The Western Ontario and MacMaster Universities Osteoarthritis Index (WOMAC) score was assessed preoperative and 1 year postoperative (0: best, 100 worst). In addition, implant survival was calculated from the Arthroplasty Registry data.

Results

In 1209 primary TKA without patella resurfacing, postoperative WOMAC total and WOMAC subscores did not differ significantly between groups, but potentially suffered from type 2 error. Three-year survival was 97.4% and 92.5% in patients with preoperative mild and severe patellofemoral osteoarthritis, respectively (p = 0.002). Five-year survival was 95.8% vs. 91.4% (p = 0.033) and 10-year survival was 93.3% vs. 88.6% (p = 0.033), respectively.

Conclusions

From the study findings, it is concluded that patients with preoperative severe patellofemoral osteoarthritis have significantly higher risks for reoperation than do those with preoperative mild patellofemoral osteoarthritis—when treated with TKA without patella resurfacing. Hence, it is recommended that patella resurfacing be applied in patients with severe Iwano Stage 3 or 4 patellofemoral osteoarthritis during TKA.

Level of evidence

III, Retrospective comparative.
Rib Fixation for Multiple Rib Fractures: Healthcare Professionals Perceived Barriers and Facilitators to Clinical Implementation
Authors: Spronk Inge , Van Wijck Suzanne F. M. , Van Lieshout Esther M. M. , Verhofstad Michael H. J. , Prins Jonne T. H. , Wijffels Mathieu M. E. , Polinder Suzanne ,   the FixCon Study Group, Blokhuis Taco J. , De Loos Erik R. , Flikweert Elvira R. , ter Gunne Albert F. Pull , Ringburg Akkie N. , Spanjersberg W. Richard , Van der Bij Gerben , Van Eijck Floortje C. , Van Huijstee Pieter J. , Van Montfort Gust , Vermeulen Jefrey , Vos Dagmar I.
Published: April 2023

Background

Surgical stabilization of rib fractures (SSRF) is associated with improved respiratory symptoms and shorter intensive care admission in patients with flail chest. For multiple rib fractures, the benefit of SSRF remains a topic of debate. This study investigated barriers and facilitators of healthcare professionals to SSRF as treatment for multiple traumatic rib fractures.

Methods

Dutch healthcare professionals were asked to complete an adapted version of the Measurement Instrument for Determinants of Innovations questionnaire to identify barriers and facilitators of SSRF. If ≥ 20% of participants responded negatively, the item was considered a barrier, and if ≥ 80% responded positively, the item was considered a facilitator.

Results

Sixty‐one healthcare professionals participated; 32 surgeons, 19 non‐surgical physicians, and 10 residents. The median experience was 10 years (P25–P75 4–12). Sixteen barriers and two facilitators for SSRF in multiple rib fractures were identified. Barriers included lack of knowledge, experience, evidence on (cost‐)effectiveness, and the implication of more operations and higher medical costs. Facilitators were the assumption that SSRF alleviates respiratory problems and the feeling that surgeons are supported by colleagues for SSRF. Non‐surgeons and residents reported more and several different barriers than surgeons (surgeons: 14; non‐surgical physicians: 20; residents: 21; p < 0.001).

Conclusion

For adequate implementation of SSRF in patients with multiple rib fractures, implementation strategies should address the identified barriers. Especially, improved clinical experience and scientific knowledge of healthcare professionals, and high‐level evidence on the (cost‐) effectiveness of SSRF potentially increase its use and acceptance.
Quantitative background parenchymal enhancement and fibro-glandular density at breast MRI: Association with BRCA status
Authors: Goodburn Rosie , Kousi Evanthia , Sanders Clarrissa , Macdonald Alison , Scurr Erica , Bunce Catey , Khabra Komel , Reddy Mamatha , Wilkinson Louise , O’Flynn Elizabeth , Allen Steven , Schmidt Maria Angélica
Published: April 2023

Objectives

To investigate whether MRI-based measurements of fibro-glandular tissue volume, breast density (MRBD), and background parenchymal enhancement (BPE) could be used to stratify two cohorts of healthy women: BRCA carriers and women at population risk of breast cancer.

Methods

Pre-menopausal women aged 40–50 years old were scanned at 3 T, employing a standard breast protocol including a DCE-MRI (35 and 30 participants in high- and low-risk groups, respectively). The dynamic range of the DCE protocol was characterised and both breasts were masked and segmented with minimal user input to produce measurements of fibro-glandular tissue volume, MRBD, and voxelwise BPE. Statistical tests were performed to determine inter- and intra-user repeatability, evaluate the symmetry between metrics derived from left and right breasts, and investigate MRBD and BPE differences between the high- and low-risk cohorts.

Results

Intra- and inter-user reproducibility in estimates of fibro-glandular tissue volume, MRBD, and median BPE estimations were good, with coefficients of variation < 15%. Coefficients of variation between left and right breasts were also low (< 25%). There were no significant correlations between fibro-glandular tissue volume, MRBD, and BPE for either risk group. However, the high-risk group had higher BPE kurtosis, although linear regression analysis did not reveal significant associations between BPE kurtosis and breast cancer risk.

Conclusions

This study found no significant differences or correlations in fibro-glandular tissue volume, MRBD, or BPE metrics between the two groups of women with different levels of breast cancer risk. However, the results support further investigation into the heterogeneity of parenchymal enhancement.

Key Points

• A semi-automated method enabled quantitative measurements of fibro-glandular tissue volume, breast density, and background parenchymal enhancement with minimal user intervention.

• Background parenchymal enhancement was quantified over the entire parenchyma, segmented in pre-contrast images, thus avoiding region selection.

• No significant differences and correlations in fibro-glandular tissue volume, breast density, and breast background parenchymal enhancement were found between two cohorts of women at high and low levels of breast cancer risk.
Magnetic resonance imaging (MRI) for local staging before salvage radical prostatectomy: a meta-analysis
Authors: Zapała Piotr , Ślusarczyk Aleksander , Rajwa Paweł , Gandaglia Giorgio , Zapała Łukasz , Zattoni Fabio , Lorenc Tomasz , Ploussard Guillaume , Radziszewski Piotr
Published: April 2023

Purpose

The reliability of magnetic resonance imaging (MRI) as a local and nodal staging tool in radio-recurrent prostate cancer (PCa) is still unclear. The present study aims at evaluating the predictive value of MRI in the detection of extracapsular extension (ECE), seminal vesical invasion (SVI) and nodal involvement (LNI) in patients after primary radio (EBRT) and/or brachytherapy (BT) before salvage radical prostatectomy (SRP).

Methods

This systematic review and meta-analysis were performed in line with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Pubmed, Scopus, and Web of Science databases were systemically reviewed to extract the data on diagnostic performance of MRI in radio-recurrent PCa.

Results

Four studies comprising 94 radio-recurrent PCa patients were included. The pooled prevalence of ECE, SVI, and LNI was 61%, 41%, and 20%, respectively. The pooled sensitivity for ECE, SVI and LNI detection was 53% (CI 95% 19.8–83.6%), 53% (CI 95% 37.2–68%) and 33% (CI 95% 4.7–83.1%) respectively, whereas specificity was 75% (CI 95% 40.6–92.6%), 88% (CI 95% 71.7–95.9%) and 92% (CI 95% 79.6–96.8%). The sensitivity analysis revealed that a single outlying study using only T2-weighted imaging instead of multiparametric MRI reported significantly higher sensitivity with significantly lower specificity.

Conclusions

This is the first meta-analysis reporting reliability of staging MRI in a radio-recurrent setting. MRI provides poor sensitivity while maintaining high specificity for local and nodal staging before SRP. However, current evidence is limited to the low number of heterogenous studies at meaningful risk of bias.
A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury
Authors: Abozaid Eman R. , Abdel-Kareem Reham H. , Habib Marwa A.
Published: April 2023

A prevalent clinical problem including sepsis, shock, necrotizing enterocolitis, and mesenteric thrombosis is intestinal ischemia/reperfusion (I/R) injury. Humanin (HN), a recently identified mitochondrial polypeptide, exhibits antioxidative and antiapoptotic properties. This work aimed to study the role of HN in a model of experimental intestinal I/R injury and its effect on associated dysmotility. A total of 36 male adult albino rats were allocated into 3 equal groups. Sham group: merely a laparotomy was done. I/R group: for 1 h, clamping of the superior mesenteric artery was done, and then reperfusion was allowed for 2 h later. HN-I/R group: rats underwent ischemia and reperfusion, and 30 min before the reperfusion, they received an intraperitoneal injection of 252 μg/kg of HN. Small intestinal motility was evaluated, and jejunal samples were got for biochemical and histological analysis. I/R group showed elevation of intestinal NO, MDA, TNF- α, and IL-6 and decline of GPx and SOD levels. Furthermore, histologically, there were destructed jejunal villi especially their tips and increased tissue expression of caspase-3 and i-NOS, in addition to reduced small intestinal motility. Compared to I/R group, HN-I/R group exhibited decrease intestinal levels of NO, MDA, TNF- α, and IL-6 and increase GPx and SOD. Moreover, there was noticeable improvement of the histopathologic features and decreased caspase-3 and iNOS immunoreactivity, beside enhanced small intestinal motility. HN alleviates inflammation, apoptosis, and intestinal dysmotility encouraged by I/R. Additionally, I/R-induced apoptosis and motility alterations depend partly on the production of nitric oxide.
Paneth cell proteins DEFA6 and GUCA2A as tissue markers in necrotizing enterocolitis
Authors: Hoffsten Alice , Lilja Helene Engstrand , Mobini-Far Hamid , Sindelar Richard , Markasz Laszlo
Published: April 2023

Previous studies suggest that Paneth cells are involved in NEC development. Defensin alpha 6 (DEFA6) and guanylate cyclase activator 2A (GUCA2A) are selective protein markers of Paneth cells. The objective was to explore DEFA6 and GUCA2A expression in intestinal tissue samples from newborn infants with and without NEC. Tissue samples from histologically intact intestine were analyzed from 70 infants: 43 underwent bowel resection due to NEC and 27 controls were operated due to conditions such as intestinal atresia, dysmotility, aganglionosis, pseudo-obstruction or volvulus. Each tissue sample was immunohistochemically stained for DEFA6 and GUCA2A. Semi-automated digital image analysis was performed to determine protein expression. Clinical data and protein expressions were compared between the groups. DEFA6 expression was lower in the NEC group (p = 0.006). Low DEFA6 correlated with risk of developing NEC in a logistic regression analysis, independently of gestational age and birth weight (OR 0.843 [CI 0.732–0.971]; p = 0.018). GUCA2A expression did not differ between the two groups.

Conclusion: Lower expression of DEFA6 together with intact GUCA2A expression indicates that NEC patients have well-defined Paneth cells but diminished defensin activity. Our results suggest that DEFA6 could be used as a biomarker for NEC.

What is Known:• Previous studies of defensin activity in NEC have been inconsistent, showing that defensin levels may be increased or diminished in NEC. GUCA2A has to our knowledge never been studied in NEC.

What is New:• This study benchmarks two specific Paneth cell markers (DEFA6 and GUCA2A) and their activity in individuals with and without NEC.• The key finding is that the NEC group had a lower DEFA6 expression compared to the Controls, while the expression of GUCA2A did not differ between the groups.
Socio-ecological challenges and food security in the ‘salad bowl’ of Fiji, Sigatoka Valley
Authors: Pickering Kerrie , Pearce Tristan , Manuel Lui , Doran Brendan , Smith Timothy F.
Published: April 2023

This article examines food security in the Sigatoka Valley, one of the most productive food regions in Fiji, in the context of recent socio-ecological challenges through a case study of Narewa village. Data were collected using semi-structured interviews (n = 25), a fixed question food insecurity experience survey (n = 25), and a free listing exercise about preferred and consumed foods (n = 24). Results revealed that while most households had access to sufficient food, the increased frequency and intensity of droughts, tropical cyclones, and flooding caused almost half to worry about meeting their future food needs. To date, a culture of sharing within the village has helped most households access food but this will likely be inadequate to meet future needs as climate change is projected to impact food production. Given that the foundation of food production in Narewa, like other villages in the valley, relies on the long-term viability of agricultural systems, better focus needs to be placed on the natural resources that form the backbone of these systems such as water availability, soil health, and slope stability and their resilience to anthropogenic and natural stressors. Efforts that focus on protecting and enhancing local ecosystems in light of expected future climate change, combined with greater attention on food storage and the use of resilient crops, and enhancing social cohesion and sharing networks are needed to avoid breaching tipping points in the food system.
Prescribing Syringes to People Who Inject Drugs: Advancing Harm Reduction in Primary Care
Authors: Chatterjee Avik , Bannister Maxwell , Hill Lucas G. , Davis Corey S.
Published: April 2023

Access to new syringes can reduce the risk of HIV and hepatitis C transmission, skin and soft tissue infections, and infectious endocarditis for people who inject drugs (PWID). Syringe service programs (SSPs) and other harm reduction programs are a good source of syringes. However, they are sometimes not accessible due to limited hours, geographic barriers, and other factors. In this perspective, we argue that when PWID faces barriers to syringes physicians and other providers should prescribe, and pharmacists should dispense, syringes to decrease health risks associated with syringe re-use. This strategy is endorsed by professional organizations and is legally permissible in most states. Such prescribing has numerous benefits, including insurance coverage of the cost of syringes and the sense of legitimacy conveyed by a prescription. We discuss these benefits as well as the legality of prescribing and dispensing syringes and address practical considerations such as type of syringe, quantity, and relevant diagnostic codes, if required. In the face of an unprecedented overdose crisis with many associated health harms, we also make the case for advocacy to change state and federal laws to make access to prescribed syringes uniform, smooth, and universal as part of a suite of harm reduction efforts.
A General Integrative Neurocognitive Modeling Framework to Jointly Describe EEG and Decision-making on Single Trials
Authors: Ghaderi-Kangavari Amin , Rad Jamal Amani , Nunez Michael D.
Published: April 2023

Despite advances in techniques for exploring reciprocity in brain-behavior relations, few studies focus on building neurocognitive models that describe both human EEG and behavioral modalities at the single-trial level. Here, we introduce a new integrative joint modeling framework for the simultaneous description of single-trial EEG measures and cognitive modeling parameters of decision-making. As specific examples, we formalized how single-trial N200 latencies and centro-parietal positivities (CPPs) are predicted by changing single-trial parameters of various drift-diffusion models (DDMs). We trained deep neural networks to learn Bayesian posterior distributions of unobserved neurocognitive parameters based on model simulations. These models do not have closed-form likelihoods and are not easy to fit using Markov chain Monte Carlo (MCMC) methods because nuisance parameters on single trials are shared in both behavior and neural activity. We then used parameter recovery assessment and model misspecification to ascertain how robustly the models’ parameters can be estimated. Moreover, we fit the models to three different real datasets to test their applicability. Finally, we provide some evidence that single-trial integrative joint models are superior to traditional integrative models. The current single-trial paradigm and the simulation-based (likelihood-free) approach for parameter recovery can inspire scientists and modelers to conveniently develop new neurocognitive models for other neural measures and to evaluate them appropriately.
The Two Logics of Autocratic Rule
Authors: Gerschewski Johannes
Published: April 2023

In The Two Logics of Autocratic Rule, Gerschewski argues that all autocracies must fulfil three conditions to survive: the co-optation of key elites into their inner sanctum, the repression of potential dissent, and popular legitimation. Yet, how these conditions complement each other depends on alternative logics: over-politicization and de-politicization. While the former aims at mobilizing people via inflating a friend-foe distinction, the latter renders the people passive and apathetic, relying instead on performance-driven forms of legitimation. Gerschewski supports this two-logics theory with the empirical analysis of forty-five autocratic regime episodes in East Asia since the end of World War II. In simultaneously synthesizing and extending existing research on non-democracies, this book proposes an innovative way to understand autocratic rule that goes beyond the classic distinction between totalitarian and authoritarian regimes. It will be of interest to scholars and students of comparative politics, political theory, and East Asian politics.
Difficulties in Accessing Medication Records at the Time of a Large-Scale Disaster
Authors: Ueno Fumihiko , Murakami Keiko , Nagai Masato , Matsubara Hiroko , Oonuma Tomomi , Matsuzaki Fumiko , Noda Aoi , Ishikuro Mami , Obara Taku , Kuriyama Shinichi
Published: April 2023

Objective:

In a large-scale disaster, medical professionals need to access medication records and provide medicines to people who cannot return home to take their daily medicines. We investigated the proportion of carrying the paper notebook or availability of the smartphone application of the medication record among people who are assumed to have difficulty in taking their medicines during large-scale disasters.

Methods:

In Japan, a web-based survey was conducted in 2018 by randomly selecting adults ≥ 20 years of age.

Results:

There were 2286 medication record owners in 3082 participants. Of the medication record owners, 784 (34.3%) took medicines that could not be missed for even a day. Among them, 724 used paper notebooks alone, 26 used smartphone applications alone, and 34 used both. Among the 724, 208 (28.8%) always carried a paper notebook. Among the 26, 16 (61.5%) could use their applications anytime. Therefore, among the 784, at least 560 (71.4%) could not always access their medication information.

Conclusions:

An awareness campaign to carry paper notebooks and install applications for medication records should be held, since only a limited number of people carry their medication records and always have access to their medication information.
The unsteady overtopping of barriers by gravity currents and dam-break flows
Authors: Skevington Edward W.G. , Hogg Andrew J.
Published: April 2023

The collision of a gravitationally driven horizontal current with a barrier following release from a confining lock is investigated using a shallow water model of the motion, together with a sophisticated boundary condition capturing the local interaction. The boundary condition permits several overtopping modes: supercritical, subcritical and blocked flow. The model is analysed both mathematically and numerically to reveal aspects of the unsteady motion and to compute the proportion of the fluid trapped upstream of the barrier. Several problems are treated. Firstly, the idealised problem of a uniform incident current is analysed to classify the unsteady dynamical regimes. Then, the extreme regimes of a very close or distant barrier are tackled, showing the progression of the interaction through the overtopping modes. Next, the trapped volume of fluid at late times is investigated numerically, demonstrating regimes in which the volume is determined purely by volumetric considerations, and others where transient inertial effects are significant. For a Boussinesq gravity current, even when the volume of the confined region behind the barrier is equal to the fluid volume,

$30\,\%$

of the fluid escapes the domain, and a confined volume three times larger is required for the overtopped volume to be negligible. For a subaerial dam-break flow, the proportion that escapes is in excess of

$60\,\%$

when the confined volume equals the fluid volume, and a barrier as tall as the initial release is required for negligible overtopping. Finally, we compare our predictions with experiments, showing a good agreement across a range of parameters.
“Who's there?”: Depicting identity in interaction
Authors: Healey Patrick G. T. , Howes Christine , Kempson Ruth , Mills Gregory J. , Purver Matthew , Gregoromichelaki Eleni , Eshghi Arash , Hough Julian
Published: April 2023

Social robots have limited social competences. This leads us to view them as depictions of social agents rather than actual social agents. However, people also have limited social competences. We argue that all social interaction involves the depiction of social roles and that they originate in, and are defined by, their function in accounting for failures of social competence.
Trait attribution explains human–robot interactions
Authors: Bigman Yochanan E. , Surdel Nicholas , Ferguson Melissa J.
Published: April 2023

Clark and Fischer (C&F) claim that trait attribution has major limitations in explaining human–robot interactions. We argue that the trait attribution approach can explain the three issues posited by C&F. We also argue that the trait attribution approach is parsimonious, as it assumes that the same mechanisms of social cognition apply to human–robot interaction.
The now and future of social robots as depictions
Authors: Malle Bertram F. , Zhao Xuan
Published: April 2023

The authors at times propose that robots are mere depictions of social agents (a philosophical claim) and at other times that people conceive of social robots as depictions (an empirical psychological claim). We evaluate each claim's accuracy both now and in the future and, in doing so, we introduce two dangerous misperceptions people have, or will have, about social robots.
Dancing robots: Social interactions are performed, not depicted
Authors: Orgs Guido , Cross Emily S.
Published: April 2023

Clark and Fischer's depiction hypothesis is based on examples of western mimetic art. Yet social robots do not depict social interactions, but instead perform them. Similarly, dance and performance art do not rely on depiction. Kinematics and expressivity are better predictors of dance aesthetics and of effective social interactions. In this way, social robots are more like dancers than actors.
A neurocognitive view on the depiction of social robots
Authors: Hortensius Ruud , Wiese Eva
Published: April 2023

While we applaud the careful breakdown by Clark and Fischer of the representation of social robots held by the human user, we emphasise that a neurocognitive perspective is crucial to fully capture how people perceive and construe social robots at the behavioural and brain levels.
The Dorian Gray Refutation
Authors: Bartneck Christoph
Published: April 2023

Theories are an integral part of the scientific endeavour. The target article proposes interesting ideas for a theory on human–robot interaction but lacks specificity that would enable us to properly test this theory. No empirical data are yet available to determine its predictive power.
Ionospheric correction of S-band tracking radar data using NavIC S-band signals in missile test range applications
Authors: Goswami Mrinal , Santra Atanu , Dan Sukabya , Ghatak Rowdra , Bose Anindya
Published: April 2023

In missile test ranges, complex missions demand precise trajectory generated by radar. Both the radar and Global Navigation Satellite System (GNSS) signals are affected by atmospheric effects, degrading their accuracy and performance. The Indian Regional Navigation Satellite System/Navigation with Indian Constellation (IRNSS/NavIC) transmits signals in the S-band together with the L-band. This paper presents a novel experimental technique to improve the tracking accuracy of S-band radars using the concurrent NavIC S-band signal. The ionospheric delay using the NavIC S-band signal is calculated first, and the results are used to improve the trajectory data of simultaneously operating S-band radars. This is a unique application of the NavIC S-band signals apart from its conventional usage. During a launch mission, for low elevation angles, the ionospheric error is found to be ~130 m while at higher elevation angles the error values are found to be ~1–3 m. The concept is validated using data from a missile test mission. This report on the use of S-band GNSS signals for the correction of S-band radar range data offers a clear advantage of simplicity and accuracy.
The Picture Theory of Disability
Authors: Firth Steven J.
Published: April 2023

The leading models of disability struggle to fully encompass all aspects of “disability.” This difficulty arises, the author argues, because the models fundamentally misunderstand the nature of disability. Current theoretical approaches to disability can be understood as “nounal,” in that they understand disability as a thing that is caused or embodied. In contrast, this paper presents an adverbial perspective on disability, which shows that disability is experienced as a personally irremediable impediment to daily-living tasks or goals-like-ours. The picture theory of disability technically constitutes a species of relational approach because its analysis references the interplay between an individual and their environment; it differs from other relational accounts, however, by interpreting disability as a certain kind of negative experience—rather than a function of that relationship. This purely descriptive theory makes no normative claims about disability and operates as both a mechanism for the evaluation of the experience of disability and a heuristic device for the proper interpretation of disability. When disability is reframed in this way, the theory offers a particularist perspective which shows if, when, where, and how disability is experienced.
Immigration and Public Support for Political Systems in Europe
Authors: Claassen Christopher
Published: April 2023

Immigration and growing diversity have been linked with pathologies such as lower social capital, the rise of authoritarian populists, intergroup conflict, and perhaps the breakdown of democracy itself. At the heart of this complex is a question relating to migration and political culture: whether immigration erodes the attitudes that sustain and legitimize democratic political systems. This paper takes a time-series, cross-sectional approach to this question by analyzing the effects of a comprehensive set of measures of immigration on dynamic estimates of trust in democratic institutions, satisfaction with democracy, and democratic support from 30 European countries. The results show that immigration does not undermine any of these forms of public support for political systems. Indeed, under some circumstances, immigration may increase public trust in democratic institutions.
Effect of glufosinate rate and addition of ammonium sulfate on annual weed control in glyphosate/glufosinate/2,4-D–resistant soybean
Authors: Duenk Emily , Soltani Nader , Miller Robert T. , Hooker David C. , Robinson Darren E. , Sikkema Peter H.
Published: April 2023

The development of glufosinate-resistant soybean cultivars has created opportunities for use of glufosinate applied postemergence for weed control. Four field experiments were conducted in 2021 and 2022 to ascertain the effect of glufosinate rate and the addition of ammonium sulfate on annual weed control in glyphosate/glufosinate/2,4-D–resistant soybean. An increased glufosinate rate of 500 from 300 g ai ha−1 improved control of common ragweed, common lambsquarters, redroot pigweed, and foxtail species and resulted in decreased density and dry biomass of common lambsquarters and foxtail species. The addition of ammonium sulfate to glufosinate increased control of common lambsquarters, 2 and 8 wk after application (WAA), and of foxtail species, 2, 4, and 8 WAA, but did not improve control of common ragweed and redroot pigweed. Increasing the dose of glufosinate from 300 to 500 g ai ha−1 improves control of common ragweed, redroot pigweed, common lambsquarters, and foxtail species; however, the benefit of the addition of ammonium sulfate to glufosinate is weed species-specific.
Stability of Vocational Interests During University Studies
Authors: Ertl Bernhard , Hartmann Florian G. , Wunderlich Anja
Published: April 2023

Abstract: Students’ vocational interests can be described by Holland’s theory of occupational choice. Holland distinguishes six interest dimensions here: realistic, investigative, artistic, social, enterprising, and conventional. Although these attributes are relatively stable during adolescence, their stability increases dramatically during university studies. Because vocational interests are often a factor in career counseling and the choice of what to study, it is essential to investigate the extent to which they develop during the first years of college. This study examines the NEPS first-year student cohort to investigate the stability of students’ interests and aspirations. The paper analyzes 2,442 male and 3,435 female students who studied within one of six major study clusters and provided data about their vocational interests at Wave 1 (study entry) and Wave 9 (about 4.5 years later close to the end their studies). The study’s results show strong and highly significant correlations for all interest dimensions, as well as a high stability of students’ aspirations. The correlations were strongest for artistic interests and weakest for conventional interests and were distinguishable between most dimensions. Furthermore, the analyses showed notable differences with respect to gender and field of study. Further analyses went beyond a variable-centered towards a person-centered approach showing that students with a stable interest vector also displayed higher profile correlations and a higher person-environment fit. The analysis shows that 28% of the sample are still developing their interests. This indicates notable adaption processes during university time that should be factored into course design, career counseling, and further research.
Sensitivity Analysis of Assimilating Doppler Radar Radial Winds Within the Inner‐ and Outer‐Core Regions of Tropical Cyclones
Authors: Feng Jianing , Duan Yihong , Sun Wei , Zhou Yike
Published: April 2023

The assimilation of Doppler radar radial wind observations is important for improving tropical cyclone (TC) prediction. However, the specific impacts and contributions of these observations over different areas are still unclear. In this study, the impact of assimilating radar radial winds within the inner‐ and outer‐cores of TCs is evaluated. For TC Mujigae (2015), analyses suggest that although the outer‐core observations better improve the upper‐level outflow of the TC, the inner‐core observations contribute more to enhancing tangential wind and updraft near the eyewall as well as correcting the TC size, warm core structure, and asymmetrical eyewall convection. The improvements conferred by the assimilating the total observations in the analysis and forecasting of TC tracks and intensities are mainly contributed by the inner‐core observations. This is probably because: (a) the model has a higher deficiency in simulating the TC inner‐core structure, which leads to a larger background deviation relative to the observations and the assimilation increment contributed by the inner‐core observations; (b) as determined by the stronger nonlinearity of the physical processes, the ensemble spread (i.e., model uncertainty) around the inner core is larger, resulting in a more distinct impact of data assimilation. The significant improvements in the inner‐core observations are further consolidated by analyses of two other TCs of different sizes and intensities, in which the number of inner‐core observations accounts for only 1/3 of the total on average. The TC inner‐core area should be a major consideration of future TC observation projects.