bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Characterization Of Non-Fermenting Gram-Negative Bacilli And Its Virulence Markers From Various Clinical Samples In A Tertiary Care Center, South India
Authors: Ramprabu. R.  , Jaya Lakshmi. S.S.  , Leela. K.V
Published: November 2022

Introduction: Non-fermentative Gram-negative bacilli (NFGNB) are an important cause of healthcare-associated infections, and theyare primarily opportunistic pathogens.Aim and objectives: To isolate and characterize the non-fermenting Gram-negative bacilli (NFGNB) from various clinical samples ina tertiary care center. To detect the virulence markers and drug resistance using molecular methods.Material and methods: Non-fermentative Gram-negative bacilli (NFGNB) from various clinical samples were identified using standardbacteriological identification methods. Conventional PCR for detection of MBLs genes of P. aeruginosa such as blaIMP, blaVIM, blaNDMand a virulence marker, Exo S gene and also MBL genes of A. baumannii such as blaIMP, blaVIM, blaNDM, blaOXA-23, blaOXA-58, and avirulence marker, OmpA gene.Results: Out of 104 NFGNB isolates Pseudomonas aeruginosa was the most common bacteria comprising 62% (n=65), followed byAcinetobacter baumannii 25% (n=26), Acinetobacter lwoffii 4% (n=4), Pseudomonas flourescens 3% (n=3), Burkholderia cepacia 3%(n=3), Stenotrophomonas maltophilia 1% (n=1), Myroides odoratimimus 1% (n=1), and Rhizobium radiobacter 1% (n=1). The resultof P. aeruginosa showed that the blaVIM gene was expressed in 25 %(n=2), the blaNDM gene was expressed in 50 %(n=4) and blaIMPwas found in 25 %(n=2). For A. baumannii, the blaNDM gene was expressed in 33% (n=6), blaOXA-23 gene was expressed in 78%(n=14), blaOXA-58 gene was expressed in 56% (n=10) with no expression of blaIMP and blaVIM genes.Conclusion: In our study we report the increased prevalence of MBL genes in P. aeruginosa and A. baumannii. This highlights theimportance of accurate identification of MBL producers and judicious use of carbapenems. Early identification and continuedsurveillance of these multidrug resistant organisms will help to prevent their spread in a hospital environment.
Isolation And Identification Of Fungi From Soil And Water In The Bahr Al-Najaf Depression
Authors: Ibtihal. A.R Al hatimi  , ,Nihad Habeeb Mutlag
Published: November 2022

The purpose of the study is to ascertain the biological variety of the fungi living in the Bahr Al-Najaf depression's soil and water. wherethe study session was split into two seasons, with the first season beginning in mid-October and the second in mid-January. With threeduplicates for each location, three water sample collection sites and three soil sample collection sites were chosen. In this study, thewater and soil of Bahr Al-Najaf were used to identify 51 fungal isolates, which were distributed as follows: 34 fungal isolates for thefirst season and 17 fungal isolates for the second season. The fungus isolated during the first season by molecular diagnostics andpolymerase chain reaction technology were two isolates of (A. caespitosus) (C. cladosporioides)3 isolates, (A. niger) 4 isolates, (A.tubingensis) 2 isolates, (A. oryzae)) Two isolates, (A. flavus) 4 isolates, (A. terrus), 4 isolates, (Alternaria arborescens) one isolate,(C. allicinum) one isolate, (Talaromyces helices) one isolate, (C. iridis), one isolate, (Metarhizium anisopliae) one isolate,(Moesziomyces aphidis) one isolate, (F. solani) one isolate, ( Talaromyces funiculosus) one isolate, (Neurospora tetrasperma) oneisolate, (Trichoderma longibrachiatum) one isolate, (A. Irpex) [1] isolate, (A. niveus) [1] isolate.As for the fungal isolates isolated in the second season, they are Fusarium sp (2) isolates, Mucor racemosus (4) isolates, Mucor sp(2) isolates, Paecilomyces sp (3) isolates, A. ibericus (1) isolate, Plectosporium tabacinum (1) isolate, A. fumigatus (1) isolate,Paecilomyces variotii (1) isolate, A. niger (1) isolate, F. culmorum (1) isolate.Five fungal isolates have been recorded globally:(C. allicinum, Moesziomyces aphidis, Talaromyces helices, Neurospora tetrasperma, A. turcosus).
New Molecular Imprinting Nano Polymer Synthesis And Characterization As A Biocompatible For Drug Delivery Applications
Authors: Hayfaa Jasim Mohammed  , Mohammed Ali Mutar
Published: November 2022

New polymeric nanoparticles were to be developed for biomedical purposes as the purpose of this study. It was thought that theproduction of materials with novel properties and functions could be accomplished by meticulous design and synthesis, as well as theresearch of structure-property connections. A novel method that we developed has excellent sensitivity, cheap cost, and high stability.The molecularly imprinted polymer (MIP) used in this method, which is based on a functional monomer named polylactic acid(PLA), Acrylic acid (AA) , Methylacrylate (MA) Chitosan (Cs), Bisphenol A dimethacrylate(BADMA) , N,Ndimethylacrylamide(DMA), Polyvinylpyrrolidone (PVP), Ethylene glycol(EG), Methyl Methacrylate(MMA). To search into thepotential use of these hydrogels in controlled drug delivery systems, were crosslinked by 1,6 hexanedioldiacrylate (HDODA) andphotoinitiated by 1-hydroxycyclohexyl phenyl ketone before being polymerized using free radical polymerization.We synthesized the water-insoluble, amphiphilic polymer MIPs and for the first time described its structure and characteristics. Thispolymer, which has a nanostructure with a size of about 40-88 nm, is the ideal biocompatible polymer for nanobioapplications.Atenolol was loaded onto a produced hydrogel, and the drug release of such hydrogels in vitro and in vivo was studied. According tothe results, raising the pH accelerated the rate of drug release. Fourier transform infrared and 1HNMR spectroscopy, thermalgravimetric measurement, and scanning electron microscopy were used to analyze the produced hydrogels. I have been studyingabout the TGA and DSC utilizing argon medium gas and a 10 oC/min heating rate. The effect of TGA shows% residue between 2-12% at 500oC and char yield between 26- 50% at 400oC. Nanocopolymer hydrogels' glass transition values (Tg) ranged from 120 to275 °C.The faculty of biological science and biotechnology at Shahid Beheshti University also conducted studies on the efficiency of thesenanocopolymers using laboratory rats., Tehran, Iran on 18 Male Wistar rats weighing 200–240 g and divided rats into several groups,a group of natural control, and other groups for the induction of high pressure by Nacl (1%) and Dexamethasone, which includes ahigh pressure control group, , groups of treatment with polymers loaded with (Atenolol), and high pressure control groups, where Theresults showed that polymers have an obvious effect on lowering blood pressure levels in rats. Additionally, to avoid the issue ofincreased loading (Atenolol) caused by the treatment process (Atenolol), which is normally what happens as a result of an overdose,as well as to reduce the number of periodic blood pressure checks.
Distribution Of Virulence Factors Genes And Their Association With Antibiotics Resistance In Streptococcus Agalactiae Isolated From Pregnant Women In Al Anbar City
Authors: Safa Nadem Alani  , Safaa Abed Latef Al Meani
Published: November 2022

Group B streptococci (GBS) are globally recognized to cause adverse pregnancy outcomes, such as stillbirths and miscarriages, andare one of the main causes of newborn sepsis and meningitis. The high resistance of GBS to antibiotics becomes difficult orimpossible to treat, becoming increasingly common, causing a global health crisis. It complicates their eradication, potentiallyleading to the development of chronic infections. A total of 181 specimens were obtained from pregnant women. Out of thesespecimens, 22 isolates were bacteriologically identified as S.agalactiae. They were collected from Al-Anbar Province hospitals.Twenty-two isolates were identified as GBS depending on cultural and microscopical properties, automated (VITEK-2 system), andmolecular identification based on atr gene, which is an essential gene expressed isolates in all S.agalactiae. Polymerase chain reaction(PCR) was used to detect the prevalence of virulence factors and antibiotic resistance genes; ermB gene was found in 22/22(100%),hly gene in twenty-one isolates (95.45%), scpB also found in twenty-one isolates (95.45%), tet gene (95.45%), mefA gene12/22(54.54%), Rib gene was found only in five isolates (22.72%), bca found in three isolates only (13.63%), bac not found in anyisolates(0%).
Quality Of Nursing Care And Its Relationship With Cancer Survivors Satisfaction: A Cross-Sectional Study In Oncology Health Center
Authors: Dalal Yehia  , Ja’far M. Alkhawaldeh  , Al-Mu’taz Bellah Abu Fares3  , Ola A. Kutah  , Noha M Al-Shdayfat  , Alaa Hassan  , Raya Alhusban  , Hala Habashneh
Published: November 2022

Background: Quality of nursing care is one of the successful factors in health care services and is considered a major contributor toenhance excellent quality of hospitals.Purpose: The aim of this study is to explore the effect quality of nursing care on patient satisfaction in cancer center.Methods: A cross-sectional design was carried out for this study in the largest cancer center. 196 oncology nurses and 120 cancerpatients were selected randomly and data were collected by using two self-reported questionnaires. Both descriptive and inferentialstatistics were used to answer the research questions for this study.Results: The study results showed that there is a positive relationship between quality of nursing care and patient satisfaction.Conclusions: All nursing staff have to participate in the monthly meeting that coordinated by a quality membership in the unit, todiscuss and share their opinion about new issues related to quality of care.Implications for practice: Nursing administration should try to ensure adequate staffing level and that nurses have a sufficient time toparticipant in quality program in the hospital.
Coexistence Of Biofilm Formation And Antibiotic Resistance Profile Of Uropathogenic E. Coli (Upec)
Authors: Ahmed Dhahir Abed  , Thamer Yousif Mutter
Published: November 2022

The bacteria known as Uropathogenic Escherichia coli (UPECs) play a major role in triggering UTIs (UTIs). Antibiotic resistanceamong UPEC strains may progress faster if UTIs in Anbar continue to be treated with beta-lactam antibiotics without antibioticsusceptibility testing. In a study evaluating cephalosporin-resistance among 141 E. coli clinical isolates, 100 were found in urinesamples. Antibiotic resistance was analyzed using the VITEK-2 system. The results indicated that resistant to most β-lactamases usedin this study was associated with biofilm formation. 88.5% of UPEC isolates that showed biofilm positive were resist to 3rd generationcephalosporins with a statistically highly significance (P=<0.0001).
Evaluation of CD4+, CD39+, FOXP3+Tregulatory cells in Iraqi Alopecia areata patients by ELISA
Authors: Omer Khudair Rhadi  , Hayfaa Mahmud Fahad
Published: November 2022

An autoimmune condition known as Alopecia areata (AA) affects the hair follicles and causes patches of noncicatricial hairloss in any area of the body with hair. The purpose of this research was to assess the presence of CD4+,CD39+, FOXP3+Treg cells in patients with Alopecia areata in Iraq. This investigation was conducted at a private dermatological clinic. 45clinically diagnosed patients and 45 healthy controls from various regions of Iraq were included in the case study. Their agesranged from 5 to 59. Using ELISA, CD4+, CD39+, and FOXP3+ were measured. The results indicated a high number ofmale patients in the age range of 21 to 30 years (33.3%) and a high percentage of female patients in the age group of 10 to 20years (30.3%), with no significant levels P> 0.05. When compared to the control group, the concentration of CD4+,CD39+,and FOXP3+ in Alopecia patients was significantly higher than in healthy individuals (P< 0.05). According to this study'sfindings, patients with AA had higher levels of CD4+, CD39+, and FOXP3+ in their blood.
A Case Report: Aneurysmal Bone Cyst Of Proximal Femur With Subtrochanteric Femur Fracture In A Child
Authors: Dr. Devank Lohiya  , Dr. Ulhas Dudhekar  , Dr. Shrut Vasavada  , Dr. Shruti Bajaj  , Dr. Shruti Bajaj
Published: November 2022

Aneurysmal bone cysts are blood-filled lesions of the bone that are benign, expansile, aggressive, and locally damaging. They havean atypical presentation and an unknown etiology. We present the case of a 17-year-old male youngster who appeared with a historyof trauma that resulted in a pathological left femur fracture. A subtrochanteric fracture complicated a slowly forming aneurysmalbone cyst in the proximal femur. Excision of the tumor with curettage and open reduction with internal fixation with a titanium elasticnail were successful treatments, and the empty space was replaced with bone graft from the left iliac crest. The gold standard fordiagnosis is a biopsy. Bone grafting should be used in conjunction with fracture fixation to achieve bony union.
Assessment Of Changes In Alveolar Bone Width Around Dental Implants At Native And Reconstructed Bone Sites With CBCT
Authors: Dr. Pragati Rawat  , Dr. Abhinav Sharma  , Dr. Prashant Singh  , Dr. Sania  , Dr. Prateek Kumar Singh
Published: November 2022

Background: The extraction of a tooth initiates a series of reparative processes involving alveolar bone, periodontal ligaments, and thegingiva.The present study was conducted to assess changes in alveolar bone width around dental implants at native and reconstructedbone sites with CBCT.Materials & Methods: 56 patients who received dental implants of both genderswere subjected to thorough oral examination followedby CBCT scan of the implant recipient site. Dental implant insertion was done following all standardized measures. Horizontal alveolarbone widths around implants at three levels (subcrestal width 1 mm (CW1), subcrestal width 4 mm (CW4), and subcrestal width 7 mm(CW7)) were measured in all patients.Results: Out of 56 patients, males were 36 and females were 20. The mean bone width at CW1 pre- surgery was 7.04 mm and postsurgery was 6.82 mm, at CW4 pre- surgery was 9.81 mm and post- surgery was 9.12 mm and at CW7 pre- surgery was 11.36 mm andpost- surgery was 11.15 mm. The difference was significant (P< 0.05). The bone width at CW1 at native bone was 0.35 mm and atARP/GBR was -0.03 mm, at CW4 at native bone was 0.58 mm and at ARP/GBR was 0.22 mm and at CW7 at native bone was 0.24mm and at ARP/GBR was 0.03 mm. The difference was non- significant (P> 0.05).Conclusion: Significant alveolar bone width resorption was observed at only the middle third of all sites.CBCT scans can be used toobserve long-term changes in the alveolar bone width around dental implants at native and reconstructed bone sites.
Evaluation Of Effect Of Dental Implant Thread Design On Marginal Bone Loss Using CBCT
Authors: Dr. Abhinav Sharma  , Dr. Pragati Rawat  , Dr. Sania  , Dr. Prashant Singh  , Dr. Jasjit Kaur Sahota
Published: November 2022

Background: Dental implants have revolutionized dentistry for managing partially and fully edentulous patients. The present studywas conducted to evaluate effect of dental implant thread design on marginal bone loss using CBCT.Materials & Methods: 90 patients who received 125 dental implants of both genders were divided into 2 groups of 45 each. Group Ipatients received spiral implants and group II patients received dual fit implants. All patients were subjected to CBCT scan taken withPlanmica CBCT machine. Patients were recalled after 6 months and CBCT scans were repeated.Results: Group I had 25 males and 20 females and group II had 22 males and 23 females. The mean marginal bone loss in group I was2.01 mm and in group II was 2.23 mm. The difference was significant (P< 0.05). The mean survival rate in group I was 96.5% and ingroup II was 95.2%. The difference was significant (P< 0.05).Conclusion: Spiral implants had higher survival rate and minimum less bone loss as compared to dual fit implants. The use of CBCTcould aid in the accurate identification of bone loss around dental implants.
Analysis Of Sputum Culture And Gram Staining In Subjects With Lower Respiratory Tract Infection: A Microbiological Assessment
Authors: Renu Goel  , Dr. Amit A. Rangari  , Dr. Sudhakar  , Dr. Swati Tewari
Published: November 2022

Background: To diagnose the LRTIs (lower respiratory tract infections) in the microbiological laboratory, the most frequentlyemployed method is the microscopic examination of expectorated sputum samples. These sputum samples are generallycontaminated with the normal flora that is resident of the oropharynx. To manage and diagnose lower respiratory tract infections,sputum collection, culture, and microscopy are vital.Aim: The present study was conducted to analyse the sputum culture and gram staining in subjects with lower respiratory tractinfections.Materials & Methods: The study included 140 sputum samples where culture and gram-staining were done. Microscopic examinationof the gram-stained sputum smears was done to assess the presence of epithelial cells, pus cells, or organisms. Bartlett’s gradingsystem was used to assess the quality of the expectorated sputum samples. Bacterial isolates were identified using standard protocols.On Mueller Hinton agar, the Kirby Bauer disc diffusion method was used for testing antibiotic susceptibility.Results: In 140 processed sputum samples, it was seen that there were 55% (n=77) acceptable samples and 45% (n=63) nonacceptable samples. Total potential pathogens obtained from the study samples were 62.85% (n=88) samples were from acceptablesamples, in 76.13% (n=67) potential pathogens were isolated, whereas, from non-acceptable samples, potential pathogens wereisolated from 23.86% (n=21) samples. On assessing the organisms isolated from the study subjects, it was seen that the most commonisolated organism was Klebsiella pneumoniae isolated from 28.40% (n=25) samples followed by Pseudomonas aeruginosa in 14.77%(n=13) samples, Staphylococcus aureus in 13.63% (n=12) study samples, Escherichia coli in 12.5% (n=11) samples, Streptococcuspyogenes in 7.95% (n=7) samples, Klebsiella oxytoca in 6.81% (n=6) study samples, Streptococcus pneumoniae in 5.68% (n=5)study samples, Acinetobacter baumannii, Citrobacter koseri, and Enterobacter aerogenes in 3.40% (n=3) study samplesConclusion: The present study concludes that in subjects with Lower respiratory tract infections, good quality sputum must beobtained, and initial screening of the sputum should be done to obtain.
A Rare Case Of Primary Squamous Cell Carcinoma Of Kidney: A Case Report
Authors: Dr. Shruti Bajaj  , Dr. K. M Hiwale  , Dr. Sunita Vagha  , Dr. Devank Lohiya
Published: November 2022

Adenocarcinomas are the most prevalent kidney neoplasms. Only a few cases of primary squamous cell carcinoma have been reported.It is responsible for 6–15% of all kidney tumors. Majorly found in males as compare to females. This case report is of is of A 65-yearold man with pain on the left side of his abdomen. CT Urography showed the right kidney measuring 11.2 x 4.9 cm and striatednephrogram in initial images with evidence of multiple non enhancing areas with peripheral enhancement, largest measuring 2.2 x 1.2cm. Mild thickening of the renal pelvis is noted. Presence of diffuse tumor ranging from size 15 x 8 x 7 cm occupying almost whole ofthe kidney with unattainable origin was observed. Primary renal squamous cell carcinomas are extremely rare tumours that are rarelysuspected or identified clinically. It is an important factor to consider while making a diagnosis of kidney tumours.
Assessment Of Antiarthritic Potential Of Carica Papaya L. Leaves Extract And Fractions: Histopathological Analysis
Authors: Man Singh  , Danish Ahmed  , Himanshu Pandey  , Rahul Deo Yadav  , Shradhanjali Singh  , Shanti Bhushan Mishra
Published: November 2022

Carica papaya L has been traditionally claimed for curing inflammation hence the present work exemplifies the anti-arthritic potential of crude leaves extract and its fractions in arthritic models. Screening on this plant has established presence of kaempferol which might possess antiarthritic properties. Kaempferol was quantitatively estimated by high performance thin layer chromatographic method in chloroform fraction and was found to be 0.08% w/w. Arthritis was induced by intraplantar administration considering formaldehyde (2%v/v), turpentine oil emulsion (10%v/v) and complete Freund’s adjuvant (1%v/v) in left hind paw of rats. Paw oedema, body weight, haematological parameters, level of serum enzyme markers, biochemical parameters, interleukin-6 and histopathological analysis were observed in all groups. Present experimental work justifies that in chronic arthritis, iinvolvement of interleukin-6 is associated with non-articular manifestations considering joint inflammation including anaemia. The plant extract and chloroform fraction possess dose dependent antiarthritic effect in acute and complete Freund’s adjuvant induced arthritic model by ameliorating the level of serum enzyme biomarkers, haematological and biochemical parameters, body weight abnormalities, interleukin-6. The experimental explanation established that extract and its fraction of Carica papaya L. revealed anti-arthritic potential.
Sublingual Piroxicam - A Painless Way In The Management Of Lower Third Molar Extraction
Authors: Shreyas Lokhande  , Kalyani Bhate  , Sayali A Awate  , Tushar Bhosale  , Murtaza Contractor
Published: November 2022

Background: This study was conducted with the need to evaluate and compare the efficacy of oral piroxicam with sublingual piroxicam in regulating post operative pain after third molar surgeryObjectives: The objectives of this study were to evaluate the efficacy of oral and sublingual piroxicam in controlling pain after third molar extraction at 4 and 6 hours with the help of VAS and time taken for ingesting the first rescue medication post operatively.Methodology: A total of 27 participants, with 52 sites which met the inclusion and exclusion criteria were selected for this study. These were then divided into two groups; one was oral piroxicam group and the other was sublingual group. The intensity of pain was recorded at 4th and 6th post operative hour using a VAS analogue scale. The time when the participant first complained of pain was recorded and the participant was given 20mg of piroxicam as a rescue medication.Results: It was observed that both the drugs were equally effective at 4th post operative hour and the pain intensity at 6th post operative hour was found to be less in the sublingual piroxicam group than the oral group. The mean time for taking the first rescue medication was greater in the sublingual piroxicam group as compared to the oral group.Conclusion: It was concluded that s
Use Of Rp-Hplc For The Analytical Method Development Of Anti-Tubercular Drug- Bedaquiline
Authors: Sayani Bhattacharyya  , Arti Mohan  , Rajendra Sandur V
Published: November 2022

A rapid sensitive and accurate method for the quantitative and qualitative estimation of bedaquiline was developed using the reverse phase HPLC (RP HPLC) method using acetonitrile and 0.1% trifluoroacetic acid as mobile phase. The system’s suitability was established. The method was validated as per ICH guidelines. The system suitability was established with a good resolution of peak and retention time of 2.27min. The linearity was established at 242nm in the range of 30-180µg/ml, with a correlation corrfiecint of 0.9999. The limit of detection and the limit of quantification was found to be 3µg/ml and 12µg/ml respectively. The accuracy and precision of the process were found to be within the limit of acceptance calculated through relative standard deviation(RSD). The robustness of the process was established with a deliberate change in the injection flow rate, the content of the organic phase and the wavelength. The chromatographic method was found to be specific for the determination of the analyte in a photodegradation study of the knownconcentration of the sample. Hence it can be concluded that the overall process is simple, rapid, accurate and robust enough for the routine analysis of Bedaquiline in pharmaceutical formulation.
A Study To Assess The Efficacy Of Health Empowerment Programme Among Care Givers On Management Of Patient With Cerebrovascular Accident Admitted In Medical Wards At Tertiary Care Hospital Chennai.
Authors: Dr.Arul Valan.P  , Gopinath Subramaniyan
Published: November 2022

Cerebrovascular Accident is the second commonest cause of death worldwide. Cerebrovascular Accident is sudden death of brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery. It is the chronic disease and also a major cause of long-term disability and has potentially enormous emotional and socio economic consequences for patients, and their families. So the study was conducted to assess the effectiveness of Health empowerment programme on level of knowledge and practice regarding care of patient with CVA. The main objectives are to assess the pretest level of knowledge and practice regarding care of patient with cerebrovascular Accident, and to determine the effectiveness of Health empowerment programme on the level of knowledge and practice among care givers of patient with cerebrovascular Accident. A quantitative research approach and pre experimental, one group pre test, post test design was chosen to assess the level of knowledge and practice regarding Health empowerment programme conducted at, Government General Hospital, Chennai, caregivers of patients with cerebrovascular Accident who satisfied the inclusive criteria were selected as samples using purposive sampling technique. A health empowerment programme comprising a power point teaching, demonstration and reinforcement regarding health empowerment programme formed the intervention of the study. The pre and post-test level of knowledge and practice was assessed using structured questionnaire and observational check list respectively. The findings of the study revealed that the pre test mean score of knowledge was 6.73 with S.D of 2.11 and the post-test mean score of knowledge was 13.45 with S.D of 1.57 The calculated ‘t’ value of 25.68 was found to be statistically highly significant.
Assess Nurses` Perception Regarding The Use Of Technological Devices In The Critical Care Units At Selected Hospital, Chennai.
Authors: V.Geetha
Published: November 2022

Background: In conditions of intensive therapy, where the patients treated are in a critical condition, alarms are omnipresent. Nurses, as they spend most of their time with patients, monitoring their condition 24 hours,are particularly exposed to so-called alarm fatigueMethods: A descriptive study design and convenience sample was used and 50 nurses (males and females) who were working in dayshift were included. Three tools were used in the study and analysed statistically. Result: The majority of study participants were female, staff nurses, age < 25.The relation between received training on each technological equipment as total, individual & training on ventilator and perception regarding positive aspects of using technology were statistically significant and there is increased patient risk due to human errors or mechanical faults, increased stress and decreased autonomy was evident on negative effects of equipments.
A Study To Assess The Effectiveness Of Iec Package On Awareness Regarding Learning Disability And Its Coping Strategies Among Primary School Teachers In Selected Schools At Chennai.
Authors: Ms. P.Kavitha  , Mrs R. Vijayalakshmi
Published: November 2022

A "learning handicap" is an inexplicable difficulty in gaining fundamental academic abilities in a person of average intelligence. These abilities are necessary for academic and professional success, as well as coping with life in general.Objectives: To determine the level of awareness among primary school teachers on learning disabilities and coping methods prior to the exam. To determine the level of knowledge of learning disabilities and coping methods among primary school instructors after the exam.To compare the degree of awareness of learning disabilities and coping methods among primary school teachers before and after the exam.Methodology: This research adopted quasi experimental (one group pre-test – post-test) research design. The data collecting tool consisted of structured questionnaire to measure primary school teachers' knowledge on learning disabilities and coping strategies that was self-developed and validated by the content experts. Findings: Pre-test levels of learning impairment and coping methods among primary school teachers revealed 91% of them had insufficient awareness, while 8 % had moderately acceptable awareness. The post-test revealed out of 60 teachers, 56 % had adequate knowledge, while 43 % of the teachers showed fairly adequate awareness towards learning disabilities and coping methods. The study's findings indicated a significant difference in instructors' pre- and post-awareness of learning disabilities and coping methods (t= 26.6 at P 0.000).Conclusion: The study findings revealed that the intervention was effective in improving the knowledge on learning disabilities and coping strategies which in turn will improve the overall quality of life of the children with learning disabilities in future.
Anti-Obesity Effect Of Bark Of Ficus Racemosa In High Fat Diet Induced Obese Rats
Authors: Sangita Bhanuse  , Vivek Gokhale  , Jayshree Dawane  , Manasi Deshpande  , Ninad Nangare
Published: November 2022

Method: In high fat diet induced obese rats, obesity-related characteristics, including body weight, serum biochemical parameterswere assessed. At the end of the experimental histological analysis were carried out. Obesity was induced in Wistar rats using a HFD for first 25days. Then from 25th day to 50th day of study F. racemosa is given in dose of 90 mg/kg and 270mg/kg along with HFD. On 0, 25th, 50th day, body weight, histological changes and other parameters were recorded. Result: Bark powder of F. racemosa significantly reduced the absolute body weight. Ingestion of HFD containing F. racemosa to rat exhibited reduction in lipid parameters. High dose (270 mg/kg b.w) of F. racemosa significantly reduced the levels of triglyceride and VLDL whereas there were few differences observed in LDL and cholesterol. Treatment groups do not exhibited any substantial decrease in BSL. Minimal changes (+1) are found in liver tissues of F. racemose and B. prionitis treated groups. Furthermore, there is a mild fatty deposition is found.Conclusion: The results imply that F. racemose (at higher dose 270 mg/kg body) has anti-obesity effects in obesity-induced rats.
Anatomical Variations Of Osteomeatal Complex In Chronic Rhinosinusitis Patients
Authors: Dr. Navin Agrawal  , Dr. Chhavi Agrawal  , Dr. Anand Sharma  , Dr. Purvi Aswani  , Dr. Shivam Narang  , Dr. Madhvi Maheshwari  , Dr. Akshita Bharagawa  , Dr. Rohit Maheshwari  , Dr. Harsh Dudhat
Published: November 2022

Aim: To study the anatomical variations of osteomeatal complex commonly associated with paranasal sinus disease using computed tomography.Methodology: A prospective longitudinal study was conducted in the ENT department of IMCHRC, Indore for a period of one year. All the adult patients with complaints suggestive of chronic rhinosinusitis for a period of more than 12 weeks, a total of 100 patients were involved in the study.Results: In our study we observed the association between sinusitis and the anatomical variations of the osteomeatal complex and it has been found pneumatized middle turbinate to have strong significant association(p<.05) with maxillary, frontal and anterior ethmoidal sinusitis. Deviated Nasal Septum was the most common finding, which was significantly associated with anterior ethmoid sinusitis. Haller cells showed association with anterior ethmoid involvement (69.2%). Bilaterally obliterated osteomeatal complex had significant association with involvement of posterior ethmoidal sinus. Amongst the patients with Paradoxical uncinate process, all (100%) showed involvement of sphenoid sinus.Conclusions: The importance of CT scan is emphasized in patients with persistent symptoms to identify the anatomical variations that may contribute to the development of chronic sinus mucosal disease.
RP- HPLC Method Development And Validation For Estimation Of Dapagliflozin In Tablet Formulation
Authors: L.B. Borse  , M.S. Wagh  , S.L. Borse  , S.P. Ahire  , I.S. Vaishnav  , V.D. Naphade  , V. S. Gulecha
Published: November 2022

A novel, sensitive, suitable and robust strong-cation-exchange RP-HPLC technique was designed and evaluated towards the purpose of identifying dapagliflozin in tablet formulation. The separation was performed with HPLC system containing UV- detector with Openlab EZchrome software and kromasil C18, and methanol and water (75:25 % v/v) as mobile phase flowing at 1.0 ml/min. using UV detector, the detection was performed at 223 nm. Dapagliflozin was eluted with retention time of 5.27 min. The results of analysis have been evaluated with respect to stability, specificity, linearity, accuracy, precision (repeatability and intermediate precision) and robustness. A simple, specific, rapid and reproducible technique has been designed in order to analyse dapagliflozin in tablet formulation.
Assessment Of The Current Prescribing Practices And Incidences Of The Prescription Error In A Tertiary Care Hospital
Authors: Ankita Singh  , Vipin kumar  , Dr Ashwani Kumar  , Dr Malvika Srivastava  , Dr Parshant Mathur  , Rishi Bhalla
Published: November 2022

Medication errors are one of the foremost common sorts of therapeutic blunder. Roughly 1–2% of conceded patients to the healing centres are endured since of the medicine blunders, the lion's share of the mistake happens at the time of endorsing, these mistakes can be possibly prevented. Prescription errors are common, by the help of daily systematic reviews of medication charts which suggest that as many as 50% of hospital admissions and 7% of medication orders are affected. A study of prescription pattern is an important tool to determine rational drug therapy, maximize utilization of resources and to reduce prescription errors. The prescriber should follow the proper guidelines for writing a prescription in order to minimize prescription errors. A prospective observational study was conducted for a period of 6 months in inpatients department of medicine and pulmonary ward of Shri Mahant Indresh hospital, Dehradun. A total of 217 subjects were observed from the medicine and pulmonary wards (IPD). Out of which 175 subjects were male and 42 were female, as compared to females, male’s patients were having more prescription errors (75.5%). An antibiotic was the class involved in majority of prescription errors. No generic drugs were prescribed. Abbreviations and allergy were the type of prescription errors identified with more incidences of error as compared to others. The study concluded that the lack of close supervision and absence of clinical pharmacist could have make things worse. Introduction of quality assurance measures and routine checks with close supervision of the prescribing intern physicians are strongly recommended.
Assessment Of Pure Tone Hearing Threshold In Niddm & Its Comparison With Healthy Individual
Authors: Dr. Navin Agrawal  , Dr. Vishal Hansrajani  , Dr. Anand Sharma  , Dr. Shivam Narang  , Dr. Sonakshi Kapoor  , Dr. Urvashi Singh  , Dr. Harsh Dudhat  , Dr. Tanmay Singhai
Published: November 2022

Aim: To assess whether patients of NIDDM have a higher incidence of sensorineural hearing loss.Methodology: A cross-sectional study was conducted included 100 participants such that 50 were diabetics and another werenondiabetics. Pure Tone Audiometry was performed on the patient, and the results were assessed by comparing them to the patient'sdiabetes duration. The IBM SPSS version 20 software was used for all data analysis. The tables were created using cross tabulation andfrequency distribution.Results: On comparing the degree of hearing loss between both the groups and the mean hearing threshold of both the ears with durationof diabetes it was found that distribution of degree of hearing loss between the cases and control was significantly different.Conclusion: The study concluded that age had the direct association with the pure tone threshold level which means by increasing theage of the diabetes patients, hearing loss also increases as revealed by the significant p value of <0. 005.
Early Histopathology In Oral Submucous Fibrosis (OSF) To Rule The Possibility Of Epithelial Dysplasia - Report Of Two Cases
Authors: Sisca Meida Wati  , Abhishek Banerjee  , Abhishek Chatterjee  , Kumarjyoti Chatterjee  , Retno Pudji Rahayu  , Theresia Indah Budhy
Published: November 2022

Oral submucous fibrosis (OSF) is a chronic scarring and progressive condition affecting the oral cavity, oropharynx and upper portion(1/3rd) of the esophagus. It is a potentially malignant disorder. It usually presents with trismus as the chronicity progresses with a palpresentation of the mucosa. Encountering a whitish patch, ulcer or a growth in the bed of Oral submucous fibrosis is something thoughtprovoking. The malignant transformation potential of Oral submucous fibrosis is comparatively higher than other premalignantconditions affecting oral cavity. The need for biopsy at any stage of OSF is a necessity to rule out underlying pathogenicity to transformtowards malignancy or dysplasia.
Biosynthesis Nanoparticles And Molecular Study To Detect Bacterial Isolated From Patients With Diabetic Foot Ulcers In Babylon Province
Authors: Mustafa Muhammed Jadooa  , Al-Bderee Nadhim Mushtaq  , Haider Turky Mousa Al-Mousawi
Published: November 2022

Objective:- Diabetic foot ulcers, the aim of the study for determine some types of microorganisms from diabetic foot ulcers thatcauses inflammation and long-term complications and activity study of ZnO NPs biosynthesis by Aspergillus niger against isolatedbacteria, collected from infected patients at general Al -Hashimiya hospital in Babylon Governorate.Methods:-collected 100 swabs, cultured it, bacteria was diagnostic by morphological and microscopic, standard biochemical tests andVitec,the isolates identified by molecular diagnosis by extraction of DNA,using specific universal primer 16SrRNA (1239bp) andpolymerase chain reaction (PCR), study biosynthesis,characterization of zinc Oxide Nanoparticles to inhibited bacterial growth.Results:-The results were (26 aerobic bacterial isolates positive) present such as Gram positive Staph aureus , as regards the aerobicGram negative bacilli, Klepsiella pneumoniae, Proteus mirabilis, Escherichia coli, The zinc oxide nanoparticles created byAspergillus niger were spherical in shape with size 13.5nm that used as antibacterial.Discussion:-Through determination of MIC were concentrations of ZnO NPs (31.25, 62.5μg /ml, 125μg/mL, 250μg/ml, 500μg /ml),(31.25, 62.5μg /ml) not prevent growth and not inhibition while 125μg/mL determine as MIC, two best concentrations are 250μg/ml,500μg /ml both give inhibition zones.conclusion:- Gram negative bacteria was predominantly for diabetic foot ulcers, Aspergillus niger was shown to be a stabilizercapable of producing spherical ZnO nanoparticles, due to is very suitable candidate to carry out antimicrobial operation, as a result toits small size.
Assessment Of Biliary Enteric Anastomosis In Benign Biliary Disorders
Authors: Dr. Srilakshmi Vemulapalli  , Dr S J Bhosale  , Dr. Nandan Madhwapathy
Published: November 2022

Background: To assess Biliary Enteric Anastomosis in Benign Biliary Disorders.Materials & methods: A total of 100 patients were evaluated. Only those patients were included which were affected by BBDundergoing biliary enteric anastomosis were enrolled. The procedures used were choledochoduodenostomy (CDD),choledochojejunostomy (CDJ), and Roux-en-Y hepaticojejunostomy (HJ). All the patients were pre-informed about the entire studyprotocol. Complete biochemical profile of all the patients was evaluated.Follow-up was done and occurrence of complications, if any,was recorded separately. All the results were recorded and analysed using SPSS software.Results: Out of 100 patients with BBD, Choledochoduodenostomy (CDD), Choledochojejunostomy (CDJ) and Roux-en-Yhepaticojejunostomy (HJ) were carried out in 41 percent, 29 percent and 30 percent of the patients respectively. While evaluating thecomplications, it was seen that leak and strictures were seen in 2 percent and 1 percent of the patients respectively.Cholangitis wasseen in 3 percent of the patients.On assessing the Uni-variate analysis for risk factors associated with complications, it was seen thatalbumin levels of less than 3.5 g/dL were significant risk factors for occurrence of complications.Conclusion: Biliary enteric anastomosis is a safe and effective method for the management of BBD
Minimally Invasive Procedure Vs Standard Open Approach For Lumbar Sympathectomy
Authors: Dr. Harshavardhan Haldipur  , Dr. R. G. Naniwadekar  , Dr H B Janugade
Published: November 2022

Aim: Peripheral arterial disease (PAD) is chronic arterial occlusive disease of the lower extremities caused by atherosclerosis. Thepresent study was conducted for comparing the efficacy of minimally invasive procedure vs standard open approach for lumbarsympathectomy.Materials & methods: 100 patients were enrolled in the present study (who were scheduled to undergo lumbar sympathectomy) andwere divided broadly and randomly into two study groups: Group 1: Patients undergoing lumbar sympathectomy by minimal invasiveprocedure, and Group 2: Patients undergoing lumbar sympathectomy through standard open approach. Only those patients wereincluded who had Ischemic rest pain that requires continuous analgesia for more than 3 weeks and Ischemic foot ulcers that failed toheal for more than 6 weeks. All the patients underwent surgical procedures according to their respective study groups. All the resultswere recorded in Microsoft excel sheet and were analysed using SPSS software.Results: Mean duration of analgesic consumption for controlling pain postoperatively was 3.9 weeks in group 1 while it was 3.7weeks in group 2. Mean operative time among the patients of group 1 and group 2 was 51 minutes and 83 minutes respectively (pvalue < 0.05). Incidence of complications was significantly higher among the patients of group 2 in comparison to the patients ofgroup 1. Mean recovery time among the patients of group 1 and group 2 was 5.2 days and 7.3 days respectively (p- value < 0.05).Conclusion: Among patients undergoing lumbar sympathectomy, minimally invasive procedure is better in comparison to standardopen procedure.
Comparison Between Yoga Exercises Versus Tai Chi Exercises For Dynamic Balance Training Among Diabetic Neuropathy Patients
Authors: Abdul Rahim Shaik
Published: November 2022

Diabetic Neuropathy is one of the most common complication known to adversely affect the vestibular system and exacerbatedisbalance and therefore increase the risk of falling. The aim of the study is to compare the effectiveness of Yoga versus Tai Chi exercisesto improve balance, gait disturbance and muscle weakness in patient of diabetic neuropathy. A total number of 60 subjects wasrandomly assigned to one of the two groups. The treatment program was followed for 8 weeks (3 times) each week and were assessedat 4th and 8th week. The two outcome measures of Berg Balance Scale and Sara Scale for assessing muscle weakness, dynamic balanceand gait disturbances were assessed to measure effectiveness. The yoga interventions brought significant improvements across variousoutcome measures over the 8 weeks period of study (BBS, p =0.036**; SARA, p=0.016**).
Digitization In Conservative Dentistry And Endodontics: A Review
Authors: Shiksha Dhawan  , Jyoti Mandlik  , Rushikesh Gir  , Aishi Sinha  , Rachita Guru  , Niharika Rawal
Published: November 2022

Technology and dentistry have combined to produce amazing results. To attain the maximum success rates, the patient's needs andtechnology have been weaved together. For the dentist, the assistant, and the patient, it offers a number of benefits. Technology hasnot only uplifted the accuracy and intricacy of dentistry but has reduced the burden on the clinician as well. Traditionally, with onlytwo- dimensional X-ray data available, establishing correct diagnosis and an appropriate treatment plan could be arduous; therapiesessentially relied on the manual skills and experience of the operator.But now, Digitalisation comes with bounty of blessings. Thespeed and simplicity of procedures, which means the patients can be in and out of the clinic with their teeth completely restored inway less time than with conventional techniques.
Detection Of Extended Spectrum Of Β-Lactamases In Utis Patients At Raipur Chhattisgarh
Authors: Jashmi Chandraker  , Ashish Saraf  , Vishwaprakash Roy
Published: November 2022

Enter obacteriaceae families are capable of producing the extended spectrum beta-lactamase (ESBL) enzyme, which results in highlevels of resistance to all beta-lactam antibiotics. For effective antibiotic therapy, to stop the spread of resistance mechanisms, and forepidemiological reasons, their detection is crucial. 53 Gram negative isolates were detected using a standard methodology in the currentinvestigation, which compared various phenotypic methods for ESBL detection. Antibiotic susceptibility testing (AST) was alsoperformed on these isolates. Phenotypic confirmatory Double Disk Synergy Test (30 mm), Double Disk Synergy Test (30 mm), ModifyDouble Disk, and the ESBL E-Test were used to further validate the presence of ESBLs. 20 ESBLs were produced in the case of DDST(30 mm), and specificity for cefepime was 84%, rising to 86% in the case of cefepime combination. The sensitivity was high forCefepime alone (92%), while in combination it was 87% and 92% with Ceftazidime and Cefotaxime. DDST (20mm) 15 ESBLproductions was seen once more. MDDST (20mm) has a sensitivity of 94% and identified 20 isolates as ESBL. The generation of 20ESBLs was seen in the ESBL E test, and Cefepime alone showed the highest level of sensitivity. As a result, it was discovered thatcefepime was the most effective cephalosporin for ESBL detection, followed by cefotaxime, ceftazidime, and cefpodoxime.
Assessment Of Efficacy Of Balloon Tamponade In The Management Of Postpartum Haemorrhage
Authors: Dr. Yamini Patil  , Dr. Sanjay kumar Patil  , Dr. Manisha Laddad  , Dr. Gauri shinde/pawar
Published: November 2022

Background: Post-partum hemorrhage (PPH) remains a major cause of maternal death with uterine atony implicated in up to 80% ofall bleedings. The present study was conducted to assess efficacy of balloon tamponade in the management of postpartum hemorrhage.Materials & Methods: 45 patients of postpartum hemorrhage were managed with balloon tamponade.Results: The mean height was 63.2 cms, weight was 145.2 kgs, gravida was 2.5 and gestational age was 37.2 weeks. Pre-balloon andpost-balloon BMI (Kg/m2) was 27.2 and 28.9, multiple pregnancies was 24 and 11, and history of uterine surgery was seen in 11 and14, mean haemoglobin was 12.4 and 12.4 respectively. The difference was significant (P< 0.05). There were 25 patients with anyinvasive procedure and 12 and overall transfusion was seen in 42 and 16 in pre- balloon and post- balloon cases respectively. Thedifference was significant (P< 0.05).Conclusion: The implementation of IUTB in PPH protocol for caesarean delivery was associated with a drastic drop in second-lineinvasive procedures.