bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Modelling using Full Factorial Design in Response Surface Methodology Applied in the Adsorptive Removal of Dye Basic Blue 9 From Synthetic Aqueous Solutions Onto Oryza Sativa Husk-derived Nano-silica Doped Smectic Clay
Authors: Kepdieu Jean Marie , Djangang Chantale Njiomou , Njimou Jacques Romain , Tchanang Gustave , Ekani Cyprien Joel , Maicaneanu Sanda Andrada , Tizaoui Chedly
Published: December 2023

The present work aimed to use Oryza sativa husk (rice husk) in the fabrication of a nanosilica-doped smectic clay for the adsorption of Basic Blue 9 in synthetic aqueous solutions. Response surface methodology was used to evaluate the effects of the considered factors namely, initial dye concentration (10 - 30 mg/L), initial pH (8 - 11), and contact time (0 - 100 min) on the adsorption process. The regression model was found to be able to predict more than 99 % of the targeted response variation in the studied range (R2 = 99.98 %) based on 95% confidence. The analysis of variance proved the significance and the accuracy of the mathematical model. The F-values (1539.08) and p-values (< 0.05) generated by Minitab21 Sofware©, indicating that almost all the independent factors were statistically significant in the studied ranges. Based on the coefficients, initial dye concentration was more influential, followed by pH and contact time. Also, concentration x pH interaction was more effective followed by concentration x contact time. The pH x contact time interaction was very weak and those results were in accordance with factorial, surfaces, and contours plots. The pseudo-second-order kinetic and Langmuir models fitted well to the experimental data with determination coefficients of 0.976 and 0.965 respectively. Under the optimal conditions (30 mg/L, pH 11, t > 50 min; and adsorbent dose of 0.5 g/L, almost 96.33% of the dye was removed. Os-sm is thus an interesting and effective alternative for the removal of BB9 in aqueous solutions.
Method Development and Validation of Simultaneous Estimation of Olmesartan Medoximil and Hydrcohlorthiazide by RP-HPLC in Pharmaceutical Dosage Form
Authors: M.Harika  , Madhuri P.Laxmi , Kamal B. Raj
Published: December 2023

Olmesartan Medoxomil and Hydrochlorothiazide can be estimated simultaneously in commercial formulations using a straightforward, quick, precise, and accurate reverse phase high performance liquid chromatography approach. A Protocol C18 ENDURO Column (250 × 4.6 mm ×5µ), with a mobile phase composed of Acetonitrile and Water 50:50 v/v, was used to estimate the concentration of the medicines in this combination. At 270 nm, the separation was seen while the flow rate was 1 ml/min. OLM and HCTZ had retention times that were, respectively, 1.4 and 1.9 minutes. For OLM and HCTZ, it was discovered that the technique was linear over the range of 10–50 µg/ml. The technique was successfully used to estimate commercial formulations after receiving ICH guideline validation.
Application of alkali-activated cements for immobilization of dry low-level radioactive waste containing copper ferrocyanide
Authors: Guzii Sergii , Zlobenko Borys
Published: December 2023

Summary: The possibility of using alkali-activated slag-Portland cement for immobilization of dry radioactive waste containing copper ferrocyanide they been confirmed. Because of optimization, the areas of existence of compositions that provide the criterion requirements for strength have been established. Introduction of magnetite additives in the amount of 14...15 wt. % (factor X1), zeolite in the amount of 6.5...7.5 wt. % (factor X2) and dry radioactive waste on the basis of copper ferrocyanide in the amount of 10...12 wt. % (factor X3) provides criterion requirements for compressive strength. The maximum value of strength – 13.2 MPa on the 28th day of hardening is characteristic for the above-mentioned quantities of additives, and it is 1.32 times higher than the standard level of strength. Introduction of zeolite for 6.5...7.5 wt. % allows to reduce the mass and density (1.07 times), radioactivity (1.09 times) of composites. Because of modelling of compound compositions, especially in the expected reactions, the factor X3 shows a weakening factor contributing to the reduction of values of output parameters. Therefore, the introduction of dry radioactive waste into the alkaline slag-Portland cement matrix containing copper ferrocyanide is limited to no more than 12 wt. %. The processes occurring in the volume of the material explain the reduction of mass, density and radioactivity of the compounds. The energy released during radioactive decay of cesium, strontium and other radionuclides is absorbed by magnetite and converted into heat. Heat promotes the removal of physically bound and partially chemically bound water from the structure of tobermorite-like low-basic calcium hydrosilicates, hydrogranates, alkaline-alkaline-earth zeolite-type hydroaluminosilicates, and copper ferrocyanide hydrate shell. However, the passage of radiolysis does not affect the kinetics of strength gain of the compounds, but contributes to the increase of their compressive strength by 1.87 times compared to the strength of the compounds on 7 days of curing
Margaret Kilpinen. Pianisti, pedagogi, puoliso
Authors: Rahkonen Margit
Published: December 2023

Margaret Kilpinen. Pianist, pedagogue, spouse The biography of Margaret Darling Kilpinen (1896–1965) represents the fields of music history and women’s studies. It brings forth a woman who is of pliable but also strong character. She was active for over four decades in the musical life of Finland. What kind of professional role, combining performing and pedagogical work, was she able to build for herself? She was the wife of a well-known, strong-willed composer who had many ties to Germany, and also the mother of a daughter. How was she able to keep up her own artistry? The book deals with Margaret’s role as a solo and lied pianist, her long career as a pedagogue in the Sibelius Academy and as a harpsichord player with a part in the rise of old music in Finland in the 1930s. There is also the microhistorical angle: While looking at Margaret as a person and her life, general tendencies and attitudes among the cultural circles of Finland of her time are revealed. The main source material for the book, which is available for use for the very first time, has been the correspondence between Yrjö and Margaret Kilpinen.
Through the prism of aesthetics. Napoleonic myth in the works of Goethe and Nietzsche
Authors:   The Herzen State Pedagogical University of Russia, Vol’skii Aleksei L.
Published: December 2023

The reception of Napoleon in Germany was carried out under the sign of an aesthetic myth. The aesthetic myth is understood as a set of theories, concepts and texts of culture based on the idea of transforming the world through artistic creativity. Starting with romanticism, the aesthetic myth determines the specifics of the German discourse of culture. Under the sign of the aesthetic myth in Germany, the image of the French emperor is also comprehended. J.W.Goethe sees in Napoleon the embodiment of genius, the secret of which he is trying to unravel. Goethe sees in Napoleon a demonic personality, “the quintessence of humanity”, a genius, a natural phenomenon. Another aesthetic category through which the image of Napoleon is comprehended is the sublime. According to Goethe, the loftiness of Napoleon manifests itself not only during his political rise, but also during his fall. Another aesthetic category through which the image of Napoleon is comprehended is the sublime. The greatness of Napoleon is manifested, according to Goethe, not only in his military and political triumph, but in his tragic fall. Nietzsche sees in Napoleon the historical anticipation of the coming superman. The political activity of Napoleon is comprehended as an analogue and continuation of German art, the reincarnation of the ancient German spirit that overcomes the modern German decadence. In contrast to Bismarck’s nationalist empire, Napoleon’s all-European empire was founded on the principles of cosmopolitanism, which, in Nietzsche’s view, corresponds to the universalist nature of the German spirit.
Why read about animals: On the formation of the animal autobiography as a literary genre in the 18th–19th century British literature
Authors:   St. Petersburg State University, Ivankiva Marina V.
Published: December 2023

The article presents an analysis of the genesis of the genre of animal autobiography in English literature at the turn of the 18th–19th centuries. The emergence, formation and evolution of the genre is considered in three contexts. The ideas of Adam Smith and David Hume together with the pedagogical teachings of John Locke and Sarah Trimmer form the central philosophi cal concepts of the new genre: sentimental feeling, sympathy, concern for the well-being of another living being. Comparison of the animal autobiography with “novel of circulation”, a popular in the XVIII century type of novel about adventures of a thing, focuses readers atten tion on animate and inanimate narrator which leads to the didactics of a new genre. Auto biographical narratives such as “The Life and Perambulations of a Mouse” of Dorothy Kilner, “Adventures of a Donkey” of Arabella Argus, and “Black Beauty” of Anna Sewell are studied in the context of the 18th and 19th century novel culture and since the authors of such autobiogra phies were predominantly women, who were responsible for caregiving and education, within the female narrative strategies in biographies. Written over two centuries ago by women who appropriated the voices of animals and spoke of their well-being, animal autobiographies are studied in terms of ecofeminist critique and human-animal studies. It is concluded that this genre may be regarded as an enlightenment project, which had and still has not only a didac tic, but also an emancipatory function.
Joseph de Maistre and Peter Chaadaev: Cultural transfer of Catholic ideas
Authors:   Sorbonne University, Pantina Marina V.
Published: December 2023

The influence of Joseph de Maistre on P.Chaadayev is a confirmed fact, though the textological analysis of his “Philosophical Letters” has not yet been carried out. The problematic aspect of the topic is the variety of interpretations of the thought of the Savoyard philosopher in Russia, which leads to the paradoxical possibility of reaching opposing conclusions based on the same works of de Maistre. He also inspired the conservative thinkers and Chaadayev, whose works were perceived by his contemporaries as opposing the theory of official nationality. The methodology used to investigate this problem is M.Espagne’s methodology of reception studies, which suggests the possibility of creating a new semantic meaning when an idea is perceived from a different cultural or political perspective. In this article, we focus on Chaadayev’s strategies in interpreting de Maistre’s thought and the significant differences that arise in adapting the Savoyard philosopher’s ideas for the readers of the “Philosophical Letters”. The novelty of the study lies in comparative analysis of the texts, which makes it possible to move away from stating the fact of borrowing to its specific use, characteristic of the author and the era when the work was written in Russia. With this approach, the focus of the study shifts to the recipient’s text and the perception of the Savoyard philosopher’s thoughts in a specific historical context.
Features of the creative imagination of primary school age children with visual impairment
Authors:   St. Petersburg State University, Darinskaia Larisa , Sorokin Victor ,   St. Petersburg State University, Molodtsova Galina ,   St. Petersburg State University
Published: December 2023

The article discusses the problem of creative imagination development in children with visual impairment. The authors proceed from the position that shortcomings of sensory cognition, in particular the images of representations in the form of schematism, fragmentation, etc., affect the development of creative imagination. In the meantime, preservation of combinatorial mechanisms can be a compensatory component in the development of fantasy in visually impaired children. In modern child pathopsychology, the question of nature of impaired vision influence on the process of imagination development remains open. On the one hand, a decrease in visual acuity enhances perceptual uncertainty which can contribute to the development of imagination. On the other hand, the narrowing of sensory experience leads to irreversible underdevelopment of creative imagination. According to the authors of the article, a visual defect can have a negative impact on the imagination development, however, a corrective effect can reveal the potential opportunities realized in the zone of proximal development. The relevance and novelty of the study are due not only to the lack of scientific developments devoted to imagination in conditions of visual impairment, but also to the importance of this phenomenon in the learning process and socio-psychological integration of visually impaired people. The purpose of the study is to conduct a comparative analysis of various features of the imagination of visually impaired and normally seeing children. Sample: visually impaired students studying in a special (correctional) school for children with visual impairments and their peers who can see normally, studying in a general education school in the first grade (25 people — the experimental group, 25 people — the control group; average age is 7–8 years). The study was carried out using the technique of finishing geometric shapes (Dyachenko, Kirillova). The data obtained indicate the negative impact of visual acuity reduction on the development of creative imagination of primary school children. This applies both to quantitative and qualitative aspects of imagination images. Nevertheless, the existing potential opportunities were clearly revealed in the course of a correctional and developmental experiment.
O POEMA DA PINTURA – RELAÇÕES INTERSEMIÓTICAS NO LIVRO POEMAS, DE PORTINARI
Authors: Jóe Márcia Maria Sant’Ana
Published: December 2023

A obra Poemas é o único livro de poemas de Cândido Portinari – sem ilustrações – e está dividida em 4 partes ou seções: “O menino e o povoado”, “Aparições”, “A revolta” e “Uma prece”. Os temas de Portinari-poeta lembram os temas do Portinari-pintor, quando se referem às alegrias e aos medos da infância em Brodósqui. Para o presente artigo, estudamos o diálogo de um único poema presente na seção “O menino e o povoado” e de um único quadro intitulado Circo, a fim de analisar as relações estéticas entre essas diferentes linguagens. O objetivo foi o de estudar o diálogo do poema de Cândido Portinari com o processo de composição de sua obra plástica, pesquisando as relações estéticas entre essas diferentes linguagens, tendo como instrumento de análise a semiótica greimasiana, especialmente os conceitos de enunciação, figuratividade, semiótica figurativa e a plástica, além de questões próprias da poética: ritmo, rima e distribuição espacial das palavras. Cândido Portinari, além de pintor e desenhista, era também poeta e é predominantemente neste aspecto que nos debruçamos neste artigo.
A LINGUAGEM CINEMATOGRÁFICA E SUAS INQUIETAÇÕES PELO OLHAR DO SINCRETISMO
Authors: Martins Fiori Fernando
Published: December 2023

Tendo em vista o valor do plano de expressão para a construção do sentido, este artigo almeja trazer reflexões sobre esse tema, no contexto do cinema. Para isso, abordamos conceitos essenciais, como os de sentido, matéria, forma e substância, para começarmos a entender as peculiaridades da linguagem cinematográfica, que sincretiza, em seu plano de expressão, elementos heterogêneos. Longe de apresentar conclusões, nosso trabalho pretende acalorar a discussão em torno dessa linguagem rica e ainda merecedora de muita profundidade analítica. A fim de estimularmos o debate, colocamos em relevo questões levantadas pela semiótica de origem francesa e pela semiologia de Christian Metz, além de cotejarmos os escritos de semioticistas consagrados, dando continuidade aos caminhos já abertos por eles no tocante ao sincretismo, mas sem deixar de trazer uma perspectiva própria sobre o que está aqui conjecturado.
Pneumonia Net: Pneumonia Detection and Categorization in Chest X-ray
Images
Authors: Srivastava Somya , Verma Seema , Das Nripendra Narayan , Sharma Shraddha , Dubey Gaurav
Published: December 2023

Background:

Pneumonia is one of the leading causes of death and disability due to
respiratory infections. The key to successful treatment of pneumonia is in its early diagnosis
and correct classification. PneumoniaNet is a unique deep-learning model based on CNN for
identifying pneumonia on chest X-rays.

Objective:

A deep learning model that combines convolutional, pooling, and fully connected
layers is presented in this study.

Methods:

In order to learn how to identify cases of pneumonia and healthy controls on chest
X-ray pictures, PneumoniaNet was trained on a large labeled library of such images. A robust
data augmentation technique was adopted to enhance the model generalization and training set
diversity. Standard measures like as accuracy, precision, recall, and F1-score were applied to
PneumoniaNet's performance evaluation.

Results:

The suggested model performed effectively in detecting pneumonia cases with an accuracy of 93.88%.

Conclusion:

The model was evaluated against the current state-of-art methods and showed that
PneumoniaNet outperformed the other models.
Putting It All Together: Clinical Pearls of Recently Approved Therapies for Triple-Negative Breast Cancer
Authors: Rygiel Katarzyna
Published: December 2023

Three recently approved therapies for the treatment of triple-negative
breast cancer (TNBC), including poly(ADP-ribose) polymerase (PARP) inhibitors,
immunotherapy, and antibody-drug conjugates (ADC) have changed the
management of several patients with advanced, metastatic, and even early-stage TNBC.
PARP inhibitors, such as olaparib and talazoparib, have been approved as therapies
for BRCA-mutated human epidermal growth factor receptor 2 (HER2)-negative
metastatic breast cancer (BC).
Immunotherapy has been approved for patients with programmed death ligand 1
(PD-L1)-positive, metastatic TNBC. Immune checkpoint inhibitors (ICIs), such as
atezolizumab and pembrolizumab demonstrated a significant improvement in
progression-free survival (PFS) (in combination with chemotherapy).
An antibody-drug conjugate (ADC), sacituzumab govitecan (SG) (that targets
trophoblast cell surface antigen 2 (Trop-2)), has shown efficacy and prolonged PFS
and overall survival (OS) in patients with metastatic TNBC.
The goal of this chapter is to briefly review some of the most promising therapies
available for the treatment of TNBC, including PARP inhibitors, ICIs, and ADCs.
Considerations of choosing these therapeutic options and their sequence, in the context
of the BRCA mutation and the PD-L1 positivity, in patients with TNBC have been
discussed.
How Can Medical Professionals Maintain Compassion for Their Patients with Breast Cancer?
Authors: Rygiel Katarzyna
Published: December 2023

Compassion in the medical field differs from its traditional meaning in daily
life. In medicine, compassion includes a desire to understand an individual’s
suffering, together with a wish to relieve it. In essence, compassion offers a unique
concept, according to which, the modern science of compassion can be practically
applied to suffering people, in many circumstances. This is particularly important for
some vulnerable groups of patients (e.g., ethnic minorities), such as women with
breast cancer (BC) (e.g., in advanced or metastatic stages, with comorbidities and
socioeconomic problems).
This chapter presents some suggestions (based on recent research reports) for helpful
strategies that medical professionals can use daily, to help maintain compassion
for their patients with serious diseases, including some aggressive cancers (e.g.,
Triple-Negative Breast Cancer (TNBC)).
Verification, Validation and Sensitivity Studies of Computational Models used in Toxicology Assessment
Authors: Mulpuru Viswajit , Mishra Nidhi
Published: December 2023

Complex computational models of biological systems are developed to
simulate and emulate various biological systems, but many times, these models are
subjected to doubt due to inconsistent model verification and validation. The
verification and validation of a model are important aspects of model construction.
Moreover, the techniques used to perform the verification and validation are also
important as the improper selection of the verification and validation techniques can
lead to false conclusions with profound negative effects, especially when the model is
applied in healthcare. The objective of this chapter is to discuss the current verification
and validation techniques used in the analysis and interpretation of biological models.
This chapter aims to increase the efficiency and the peer acceptability of the biological
prediction models by encouraging researchers to adopt verification and validation
processes during biological model construction.
O Potencial de Representação da Narrativa Gráfica: Nódoa Negra e a Dor no Feminino
Authors: Frota Silvia , Soares Marta
Published: December 2023

O sucesso e a popularidade que as narrativas gráficas têm alcançado nestas últimas décadas fazem delas um poderoso objeto mediático de comunicação e expressão. Fortemente associadas à cultura popular e de massas, ao entretenimento e à facilidade de leitura, interessa perceber a sua aptidão para a abordagem de temas complexos, como a representação da dor no feminino, frequentemente negligenciada cultural e cientificamente. Nesse sentido, a análise de Nódoa Negra (Lopes et al., 2018), volume de banda desenhada coordenado por Dileydi Florez e que reúne narrativas gráficas criadas por mulheres em torno da temática da dor, mostra-se aqui particularmente relevante. Neste artigo, propomo-nos a explorar o potencial da narrativa gráfica para representar a dor no feminino, tomando como exemplo várias narrativas incluídas em Nódoa Negra. O duplo código semântico texto-imagem, característico da linguagem das narrativas gráficas, permite a multiplicação de recursos discursivos, promovendo maior amplitude de representações. Ao dizer o que não pode ser mostrado, mostrar o que não pode ser dito, e promover a construção de significados no espaço intersticial entre texto e imagem, a narrativa gráfica permite um maior refinamento e expressividade da dor na sua abstração e concretização, entre o dizível e o indizível. O enquadramento teórico-metodológico adotado incide sobre os estudos de cultura e comunicação, os estudos críticos do discurso e as humanidades médicas.
Escala de Clima Ético Universitário (ECEU): Propriedades psicométricas
Authors: Frick Loriane Trombini , Matias Zechi Juliana Aparecida , Stelko Pereira Ana Carina , Nozaki Yano Vitor Atsushi , Moreira da Cunha Josafá , Cortez Pedro Afonso
Published: December 2023

Compreender o Clima Ético Universitário é fundamental para a promoção de políticas e práticas institucionais que visem a formação ética dos atores sociais inseridos neste espaço. Assim, o objetivo deste estudo foi desenvolver um novo instrumento para avaliar o Clima Ético Universitário, para o contexto brasileiro, e analisar as suas evidências de validade baseadas na estrutura interna, consistência interna e validade critério. A amostra foi composta por 3.484 universitários, com idade média de 22,8 anos (DP = 6,92). A escala é um instrumento de autorrelato, com 28 itens. Empregou-se análise fatorial exploratória e confirmatória, resultando em uma  escala formada por oito fatores de primeira ordem: segurança, acolhimento institucional à diversidade, engajamento acadêmico institucional, indicadores de vitimização, bem-estar, indicadores de ansiedade e depressão, enfrentamento institucional ao abuso ou assédio, suporte social e institucional percebido, os quais conjuntamente explicam cerca de 71,3% da variância, e um fator de segunda ordem: clima ético universitário. As correlações evidenciaram validade convergente entre os fatores positivos da escala, como segurança, respeito e não discriminação; e validade divergente entre os fatores negativos da escala, como indicadores de vitimização, de ansiedade e depressão, e os fatores de segurança e respeito e não discriminação. Em relação à validade preditiva, verificou-se que seis dos oito fatores foram preditores da ocorrência de respeito e não discriminação. Os resultados apontam a escala como uma alternativa confiável, prática e original para avaliações de Clima Ético Universitário, podendo ser ferramenta de análise que oriente ações institucionais para promoção da convivência ética.
The Resilience of Borders: Law and Migration in Contemporary Performances
Authors: Tindemans Klaas
Published: December 2023

Legal philosopher Hans Lindahl argues that the regulation of immigration is, above all moral considerations, a political issue. When one tries to assess the problem of territorial boundaries – and their transgression – as a question of distributive justice, political philosophers easily mix, not even surreptitiously, moral arguments with political and legal considerations. Lindahl refers to Michael Walzer, who asserts the primacy of the community and consequently bounded justice, and to Jürgen Habermas, who’s idea of boundless justice makes the notion of a nation-state irrelevant: one world polity has, by definition, no boundaries and thus no immigration issues. But Lindahl replies that law, and immigration law in particular, is forced to create boundaries by its very nature. After all, law structurally defines diverse groups of interest, and the actions of individuals – belonging or not belonging to one group or another – are always placed or misplaced, i.e. situated inside or outside the realm of the law. Even a world legislature and a universal jurisdiction would have to decide who can claim her/his rights, or who cannot. But since law is also, by definition, contingent – it can be changed in any direction – the claim of distributive justice, as a form of moral pressure, cannot be discarded easily. It shouldn’t be discarded, to be sure, it should be politicized. In recent performances about immigration, the moral indignation has clearly had the upper hand, sometimes with a touch of cynicism. In Necropolis, Arkadi Zaides creates a fictitious city of the dead, where only those who died in their attempt to reach Europe are allowed. From a massive collection of data about the victims of Fortress Europe, his performance transforms into a horrifying portrait of their ‘human remains’. Het Salomonsoordeel, a documentary, participatory monologue by Ilay den Boer involves the audience in the moral dilemmas of the ‘decider’ of the Dutch immigration and asylum agency, where den Boer worked as an intern. In The Voice of Fingers, Thomas Bellinck confronts his friendship with asylum seeker Said Reza Adib with the harsh reality of migrants as ‘data subjects’, identified by their fingerprints. The question arises of whether artistic representations of immigration issues sufficiently tackle the political challenges of global mobility – in this collapsing world of (civil) wars, climate disasters, and economical inequalities – and the challenges it poses for the affluent societies we are living in. Is it possible, or even meaningful, for theater-makers to try to relate their compassion – as a moral sentiment – to the frameworks of contingent policies and, subsequently, to the strict taxonomies of legislation?
Exploring the views of nurses and supervisors on leadership competencies for enhanced primary healthcare services
Authors: Lagura Grace Ann Lim , Rondilla Evalynn M. , Saguban Reynita B. , Alotibi Bedowr Khalid , Pangket Petelyne P. , Celdran Ma Christina B. , Tano Maria Fe , Alenizi Sara Farhan , Buta Joyce B. , Enriquez Lucibel D. A. , Dando Lea L.
Published: December 2023

High-quality patient care in primary healthcare (PHC) settings depends on the professional skills of nurse supervisors. Competent nurse supervisors can efficiently manage resources such as staff, tools, and workflows to provide the best possible patient care. The purpose of this study was to determine the perspectives of nurse supervisors and nurse managers on the competencies required of nurse supervisors for improved service delivery in PHC settings. This study used a descriptive-quantitative design and was conducted in the north-central regions of Saudi Arabia. The researchers used convenience sampling to recruit 107 PHC nurse supervisors and 110 nurses. The study found that most of the respondents were female supervisors (93%), staff aged between 20 and 44 years (88%), graduate staff (48%), and supervisors with more than five years of hospital experience (44.4%). According to the nurses' perception, the communication skills of the supervisors were low (M=8.42, SD=1.12). On the other hand, nurse managers rated themselves as having low communication skills (mean=7.64, SD=2.00) and financial management skills (mean=7.87, SD=1.95). The study found that nurses believed their supervisors were competent. However, both staff and supervisors identified a need for improvement in communication skills. Financial management skills were perceived as weak by nurse supervisors.
ORAL MUCOSAL ULCER INDUCTION METHODS IN RATS: A SYSTEMATIC REVIEW
Authors: ERIS NURUL RAHMADHINI  , WAHYUNI INDAH SUASANI
Published: December 2023

Oral mucosal ulcers are a prevalent condition, but there are still limited drugs available to treat them. Varieties of induction techniques to obtain oral mucosal ulcer models in rats have frequently been used. This systematic review aimed to describe different approaches and to recommend the most effective method for oral mucosal ulcer induction methods in rats for anti-oral mucosal ulcer drug discovery. The PRISMA guidelines were used in the framework regarding this systematic review. The electronic databases PubMed, Science Direct, SCOPUS, and EBSCOhost-CINAHL Plus were used for article searching using specific keywords. The Risk of Bias Tool from Syrcle was used to undertake the evaluation of bias risk. Based on the analysis of 14 articles, the following findings were gathered: Wistar rats were frequently used mouse strains at an average of 8 w old and weighed between 120 and 300 g. Induction methods used to obtain ulcer models were acetic acid, biopsy punch, scalpel blade, thermal, and phenol. Acetic acid induction was the most commonly used compared to the other induction techniques. The ulcers were obtained by acetic acid identical to those that occur on the human oral mucosa and available at a reasonable price. However, the ulcer formation takes longer compared with biopsy punch and scalpel blade induction. The systematic review found that there are various methods for inducing oral ulcers in rats, with acetic acid being the recommended method to produce a suitable mucosal ulcer model in rats.
ANTIOXIDANT ACTIVITIES AND PHYTOCHEMICAL SCREENING OF ETHANOL EXTRACT FROM SURIAN LEAVES (TOONA SINENSIS)
Authors: LESTARI UCE , MUHAIMIN MUHAIMIN , CHAERUNISAA ANIS YOHANA , SUJARWO WAWAN
Published: December 2023

Objective: The objective of the present study is to determine antioxidant activities and phytochemical screening of ethanol extract from surian leaves (Toona sinensis).

Methods: This study evaluated the antioxidant activity and conducted phytochemical screening of ethanol extracts obtained from surian leaves. Phytochemical screening was performed using qualitative Thin-Layer Chromatography (TLC), and antioxidant activity was assessed using the DPPH method.

Results: The results revealed the presence of polyphenolic compounds (153.10±0.310 mg/g), tannins, flavonoids (33.19±0.890 mg/g), monoterpenoids, quinones, and saponins with Rf values of 0.607±0.019 (flavonoids) and 0.958±0.019 (terpenoids) 0.513±0.038 (steroids) 0.418±0.019 (phenolics). The antioxidant activity test of the ethanol extract from Surian leaves yielded an IC50 value of 12.351±0.092 ppm, which closely matches the IC50 value of the reference vitamin C (7.805±0.686 ppm).

Conclusion: In conclusion, based on research methods, the ethanol extract of surian leaves contains flavonoid and phenolic compounds which show strong antioxidant activity.
IMMUNOSTIMULANT ACTIVITY OF HANTAP (STERCULIA COCCINEA JACK) LEAVES EXTRACT ON NON-SPECIFIC AND SPESIFIC IMMUNE RESPONSES
Authors: YULIET  , KHAERATI KHILDAH , WIDODO AGUSTINUS , SHARON NELA , TANDI JONI
Published: December 2023

Objective: This study aims to determine the immunostimulant effect and the effective dose of hantap leaf ethanolic extract against non-specific and specific immune responses.

Methods: The immunostimulant activity of the extract was tested by the carbon clearance method (non-specific response). The effect of the extract on delay-type hypersensitivity/DTH (cellular-specific response) was determined by the paw edema method. The number of leukocyte cells and the percentage of leukocyte cell types were also calculated. The antibody titer (humoral-specific response) test was carried out by the hemagglutination method.

Results: The results of the non-specific immune response demonstrated that three doses of hantap leaf extract, when compared to the negative control, could accelerate the rate of carbon elimination and increase the phagocytosis index. Hantap leaf extract can provide an immunomodulatory effect by increasing the delayed-type hypersensitivity response by showing a greater volume of leg swelling than the negative control received CMC Na 0.5%, which was significantly different (p<0.05), increasing leukocyte count and leukocyte differential and increasing primary and secondary antibody titers. The effective dose of hantap leaves extract was 200 mg/kg body weight.

Conclusion: This study proves that hantap leaf extract has an immunomodulatory effect that increases the immune system (immunostimulant)
POLYHERBAL FORMULATION OPTIMIZATION FROM CLITORIA TERNATEA, ROSMARINUS OFFICINALIS AND AQUILARIA MALACCENSIS USING SIMPLEX LATTICE DESIGN
Authors: AKMAL TUBAGUS , JULIANTI ANDI IKA , SYAMSUDIN SILVIA SYADZA’AH
Published: December 2023

Objective: This study aimed to optimize the composition of Clitoria ternatea flowers, Rosmarinus officinalis herbs, and Aquilaria malaccensis leaves as a polyherbal formulation.

Methods: The polyherbal formulation (PHF) was systematically optimized using a simplex lattice design generated by Design Expert software. The selected independent variables were the percent of C. ternatea flowers extract (X1), the percent of R. s officinalis herbs extract (X2), and the percent of A. malaccensis leaves extract (X3). The dependent variables were total phenolic contents (Y1) and 2,2-diphenyl-l-picrylhydrazyl (DPPH) radical scavenging activity (Y2).

Results: The results showed that the optimum composition of PHF was C. ternatea flowers extract (10%), R. officinalis herbs extract (80%), and A. malaccensis leaves extract (10%) to obtain 135.794 mg GAE/g dried extract for total phenolic contents and 22.879 µg/ml (IC50) for DPPH radical scavenging activity.

Conclusion: The findings suggest that the polyherbal formulation consisting of C. ternatea flowers (CTF), R. officinalis herbs (ROH), and A. malaccensis leaves (AML), when formulated with the optimal composition has the potential to enhance the total phenolic content and antioxidant activity.
INTERACTION EFFECT OF APIS TRIGONA HONEY, ETHANOLIC EXTRACTS KEMUNING (MURRAYA PANICULATE), YAKON (SMALLANTHUS SONCHIFOLIUS) AND THEIR COMBINATION AGAINST STAPHYLOCOCCUS AUREUS INFECTIONS
Authors: KUSUMA SRI AGUNG FITRI , HERAWATI IRMA ERIKA , RAMDHANI DANNI , RISNAND ALYA
Published: December 2023

Objective: This study was investigated the antibacterial interaction of Murraya paniculate extract, Smallanthus sonchifolius extract, Apis trigona honey and their combinations for their interaction effect against Staphylococcus aureus ATCC 29213.

Methods: All extracts and honey were evaluated for antibacterial interaction effects both alone and in combination. The disk diffusion method was employed with clindamycin phosphate as the standard antibiotic. The minimum inhibitory concentration (MIC) of the most potent extract was determined using microdilution assays and performed in line with CLSI guidelines.

Results: Among all, S. sonchifolius extract provided the most effective inhibitory activity in higher inhibition than clindamycin phosphate with the range MIC value of 12.5-25% w/v. However, significant different interactions (synergistic, additive and antagonistic) were observed between honey and plant crude extracts. The S. sonchifolius extract displayed additive interaction with M. paniculate extract but antagonistic with A. trigona honey. The antagonistic interaction also produced when M. paniculate extract combined with A. trigona honey. Consequently, their total combination of all tested sample produced an additive interaction.

Conclusion: Thus, we concluded that their combination was ineffective to be used as the antibacterial cocktails against S. aureus infections.
EFFECT OF HYDROXYPROPYL METHYLCELLULOSE (HPMC) AS GELLING AGENT ON PHYSICAL CHARACTERISTICS AND ANTIBACTERIAL POTENTIAL OF TAMOENJU LEAVES EXTRACT GEL (HIBISCUS SURATTENSIS L) AGAINST STAPHYLOCOCCUS AUREUS
Authors: SHARON NELA , YULIET  , PRATIWI RITHA , SULISTIANA SRI
Published: December 2023

Objective: The target of the study was to know the impact of gelling agent in tamoenju (Hibiscus surattensis L) leaves extract gel and evaluate their physical characteristics and antibacterial potential.

Methods: Three gel formulations were prepared using different concentrations (1, 1.5, and 2%) of gelling agents HPMC and they were evaluated for physical characteristics such as organoleptic, pH, viscosity, spreadability, adhesiveness and antibacterial potential against Staphylococcus aureus.

Results: The consequences of the organoleptic test for three recipes showed a blackish-green color with a thick texture. The addition of tamoenju leaves extract to the gel base affected the base pH from pH around 7 to 4.4-4.5 and increase viscosity of the gel. The spreadability test of F2 and F3 met the standard, namely 5-7 cm. The adhesion test of the three formulas met the standard for more than 4 seconds. The inhibition test against S. aureus for the three formulas had an inhibitory activity ranging from 10-11 mm, categorized as a moderate and strong category.

Conclusion: Antibacterial gel formulations can be made using tamoenju leaf extract. The physical stability parameters of all gel preparations containing tamoenju leaf extract show good results on day 1, but they alter after 36 d of storage. F2 (1.5% of HPMC) outperformed the other formulations in terms of physical stability and has the strongest inhibitory effect against the growth of Staphylococcus aureus.
IN SILICO STUDY OF EUCALYPTOL FROM EUCALYPTUS GLOBULUS LABILL. AGAINST ANGIOTENSIN-CONVERTING ENZYME AS AN ANTIHYPERTENSIVE IN COVID-19 COMORBID
Authors: MUSTARICHIE RESMI , SAPTARINI NYI MEKAR , PRATAMA EDWIN , MEGANTARA SANDRA
Published: December 2023

Objective: This study aimed to determine the best compound from the 62 compounds of Eucalyptus globulus Labill. as an antihypertensive based on its interaction with angiotensin-converting enzyme (ACE) using the in silico study.

Methods: The study was carried out in silico through molecular docking simulations, analysis of potential compounds using Lipinski’s rule, and ligand-based ADMET prediction on 62 compounds of the E. globulus.

Results: It was found that eucalyptol (1,8-cineole) had the best interaction with the ACE as indicated by a bond energy value (∆G) of-6.40 kcal/mol with an inhibition constant of 20.82 µM, and interacted with key amino acid residues in captopril, namely HIS513, HIS353, TYR523, and ALA354. Eucalyptol also had good physicochemical properties by fulfilling Lipinski’s rule and had the best ADMET profile compared to other compounds.

Conclusion: Eucalyptol was the best antihypertensive against ACE based on amino acid residue interaction, physicochemical properties, and ADMET profile.
Nature as the Fecund Female in Joseph Conrads Heart of Darkness
Authors: Fulsaundar Prof. Priyanka
Published: December 2023

Abstract: The Currency Detection Android Application with Image Processing is an innovative solution designed to empower visually impaired individuals and assist travelers in identifying and managing paper currency notes with accuracy and convenience. This application leverages advanced image processing techniques, including edge detection, color analysis, texture recognition, and optical character recognition (OCR), to extract crucial features from currency notes. Machine learning models, including convolutional neural networks (CNNs) and recurrent neural networks (RNNs), are employed to recognize currency denominations based on these extracted features. The application provides real-time audio feedback, announcing the recognized denomination, and features a user-friendly interface with voice-guided instructions, catering to both visually impaired and sighted users. A comprehensive currency library ensures coverage of major world currencies, with regular updates to accommodate new designs and security features. Offline functionality further enhances accessibility. The project's scope encompasses primary functionalities, target audience, supported currencies, technological considerations, and acknowledges project limitations.
Research Paper on Green Cloud Computing
Authors: Kumar Mrs. Sandeep , Varsha Km.
Published: December 2023

Abstract: Nowadays Cloud Computing is most important part of IT Industries. Cloud Computing Which is based on cloud (internet) but Internet Play Most Important Role for Cloud Computing this is the bunch of software, hardware and internet. It has lot of benefits in computing. Cloud computing provide shared file of computing resources that can fastly and easily provisioned and released based on user’s demand to service for wide use and it is constantly spreading in amount of range of information in processing needs. First time cloud computing has come in 2006 but Cloud Computing has come of age later Amazons introduce the first of its kind of cloud services. It was suitable for unbelievable amount of data. That are being processed here daily in several sectors, and there are signs that subscription to cloud services by the local IT companies will soon be on a crash course, despite a slow start in beginning years. As in research field.
Membina Guru Penggerak Reflektif Melalui Pendampingan Penyusunan Analisis Transkrip Aliran Dialog Pembelajaran
Authors: Ainur Rofieq  , Endrik Nurrohman  , Samsun Hadi  , Prastika Fitroh Nilla , Hapsari Hapsari , Indrawan Prasetyo
Published: December 2023

Background: Dosen Pendidikan Biologi UMM dan Guru SMPN 1 Sumberpucung telah berkolaborasi mengimplementasikan LS-LC. Namun, masih ditemukan beberapa kendala. Kegiatan ini bertujuan untuk membantu Guru Penggerak dalam analisis penyusunan transkrip dan aliran dialog pembelajaran. Metode: Kegiatan ini dilakukan melalui Workshop dan pendampingan yang diikuti oleh 11 guru (Biologi, Bahasa Indonesia, Sosiologi) yang dilaksana pada Juni 2021-Februari 2022. Tahapan kegiatan meliputi 1). Workshop: pemberian materi tentang aplikasi adobe premier pro, penyusunan analisis transkrip pembelajaran, 2). Pendampingan: pengembangan dan pemanfaatan video pembelajaran. Analisis data dilakukan secara deskriptif. Hasil: 1) Guru memiliki keterampilan menggunakan aplikasi adobe premiere pro, 2) terwujudnya 3 aliran dialog pembelajaran berbasis LS-LC student center berbasis praktik, 3) terwujudnya 3 video pembelajaran yaitu: (1) Biologi, materi keanekaragaman hayati kelas X, (2) Bahasa Indonesia, materi teks prosedur kelas X, dan (3) Sosiologi, materi kelompok sosial kelas XI. Video berisi pendahuluan, isi materi, dan penutup. Kesimpulan: Guru dapat menyusun analisis transkrip dan aliran dialog pembelajaran berbasis LS-LC serta mengembangkan video pembelajaran menggunakan adobe premiere pro. Tindak lanjut dari kegiatan ini adalah pemanfaatan video pembelajaran dengan melibatkan peserta didik pada saat pembelajaran sesuai dengan materi yang telah dikembangkan oleh guru.
Pengenalan Mendeley untuk Pengelolaan Referensi Penulisan Karya Ilmiah bagi Mahasiswa UTD
Authors: Ida Afriliana  , Aries Setyani
Published: December 2023

Setiap mahasiswa diwajibkan untuk menghasilkan sebuah karya ilmiah, baik itu untuk laporan praktik kerja lapangan atau untuk menuliskan hasil laporan tugas akhir bagi mahasiswa diploma tiga ataupun strata satu. Dalam penulisan karya ilmiah, penulisan sitasi dan pengelolaan referensi jurnal merupakan hal yang penting. Tujuan dilaksanakannya pengabdian masyarakat ini adalah untuk memberikan peningkatan keterampilan kepada mahasiswa Universitas Teknologi Digital (UTD) Kota Tegal dalam hal penulisan sitasi dan pengelolaan artiel jurnal sebagai referensi penulisan karya ilmiah menggunakan Mendeley. Mitra dalam pengabdian masyarakat ini adalah mahasiswa semester 6 dan mahasiswa semester 4, UTD Kota Tegal yang berjumlah 50 mahasiswa. Metode pengabdian masyarakat ini dilakukan dengan ceramah, pelatihan dan pendampingan, mulai dari instalasi mendeley hingga penggunaan mendeley dalam menuliskan sitasi dan penulisan daftar pustaka secara otomatis. Pengambilan data dilakukan dengan cara memberikan kuisioner sebagai instrumen untuk mengetahui sejauh mana pemahaman mahasiswa terhadap materi yang disampaikan hingga impelementasinya pada proses penulisan   laporan kerja praktik lapangan (PKL) bagi mahasiswa semester 4 dan penulisan laporan tugas akhir bagi mahasiswa semester 6. Hasil dari pengabdian masyarakat ini adalah semua mahasiswa telah mengimplementasikan mendeley dalan penulisan laporan karya ilmiah dan hanya beberapa mahasiswa yang belum mahir dalam penggunaan sitasi dengan memanfaatan mendeley desktop ini.Dengan adanya pelatihan pengenalan dan implementasi mendeley kepada mahasiswa UTD ini telah memberikan peningkatan kemampuan keterampilan mahasiswa dalam hal penulisan jurnal ilmiah kepada mahasiswa, khususnya untuk melakukan sitasi, pengelolaan artikel jurnal ilmiah sebagai referensi penelitian dan cara menuliskan daftar pustaka secara otomatis.Metode yang digunakan dalam pengabdian masyarakat ini adalah ceramah tentang mendeley dan implementasinya.
Pengembangan “ARA Berkelana” Sebagai Alat Assessment Responsibilty Berbasis Keunggulan Lokal PANTURA Untuk Pelatihan Guru SD 5 Bae
Authors: Sekar Dwi Ardianti  , Savitri Wanabuliandari  , Fajar Nugraha
Published: December 2023

Pendahuluan: Penguatan pendidikan karakter di Indonesia mengalami beberapa kendala, salah satunya penurunan self responsibility siswa. Self responsibility penting untuk dikembangkan karena dalam masa pandemi masih  banyak  siswa yang tidak bertanggung jawab terhadap kewajibannya. Tujuan dari kegiatan ini adalah menghasilkan “ARA Berkelana” Application of Responsibilty Assessment Berbasis Keunggulan Lokal PANTURA sebagai alat assessment self responsibility untuk pelatihan bagi Guru SD 5 Bae. Metode: Metode yang digunakan, yaitu kualitatif yang dimulai dari tahap analisis kebutuhan awal, perancangan, dan pengembangan aplikasi serta evaluasi. Evaluasi kegiatan ini dilakukan dengan menggunakan teknik non tes meliputi teknik wawancara dan teknik dokumentasi. Hasil: Hasilnya, tersedianya “ARA Berkelana” Application of Responsibility Assessment Berbasis Keunggulan Lokal PANTURA sebagai alat assessment self responsibility untuk pelatihan bagi Guru SD 5 Bae. Kesimpulan: Pengembangan aplikasi assessment untuk mengukur self responsibility siswa disusun sesuai dengan kebutuhan pengguna dan indikator self responsibility. ARA Berkelana dikembangkan dengan mengintegrasikan keunggulan lokal PANTURA sebagai alat assessment self responsibility untuk pelatihan guru SD 5 Bae.