bluuebunny/crossref_metadata_2025 huggingface dataset:
circKMT2E Protect Retina from Early Diabetic Retinopathy through SIRT1 Signaling Pathway via Sponging miR-204-5p
Authors: Shi Jilai , Li Li
Published: October 2022

Objective. To explore the changes of circRNAs in the retina of diabetic patients without diabetic retinopathy (DR) to screen latent protective factor. Methods. The sequencing data of the retina from three diabetic donors that possess no noticeable pathological feature of the retina at ultimate eye inspection and three healthy donative samples were involved in this study. Herein, we carried out bioinformatics analysis to disclose the expression pattern and characteristics of circRNAs on the basis of Gene Ontology as well as KEGG pathway analyses. Then, sequencing data were applied to infer the interaction between selected circRNAs and miR-204-5p. The potential miRNA response elements for the annotated circRNAs and their target gene were speculated using TargetScan as well as miRanda. Results. RNA sequencing detected 28,978 alternative circRNAs. Thereinto, 1063 were expressed with significant difference. circKMT2E was upregulated more than two folds in alloxan-induced diabetic retinal tissues compared with normal retinal tissues, exhibiting an expression trend opposite to miR-204-5p. Bioinformatics analysis showed that circKMT2E have four seed sequences on hsa-miR-204-5p. Thus, circKMT2E was speculated to have function on the basis of sponging miR-204-5p in order to participate in the pathogenetic process of DR. Besides, miR-204-5p was speculated to be able to bind SIRT1, which can interact with its target proteins, and adjusts various cell functions including cellular inflammatory responses, proliferation, as well as apoptosis. Conclusion. The upregulation of circKMT2E in the early stage of DR may be involved in its pathogenesis and may activate the SIRT1 signaling pathway to protect the retina by the sponge function to miR-204-5p.
Optimized Demand Information Sharing Model of Dual-Channel Supply Chain in E-Commerce
Authors: Song Yiming , Wu Shun , Zhou Yang , Pan Yiting , Sudhir Kumar
Published: October 2022

In the dual-channel supply chain, the relationship between the electronic direct selling channel and the traditional selling channel is situated in an antagonistic game. The present study used the master-slave game model to analyze the dual-channel supply chain structure, where the manufacturer is the leader of the game, and the seller is the follower of the game. Based on the game analysis theory, the game order of manufacturer and seller is analyzed in the state of demand information sharing. The decision model of each member in the dual-channel supply chain is constructed, and the optimal production decision and product price decision under the demand information sharing between the seller and the manufacturer are determined by the reverse induction method. The expected economic benefits of both are calculated, respectively. The experimental results showed that the economic benefit of the model is higher than that of the traditional demand information nonsharing model, which could enhance the economic benefit of the manufacturer and the seller at the same time and alleviate the contradiction between the electronic direct selling channel and the traditional selling channel.
Tetrandrine Attenuates Podocyte Injury by Inhibiting TRPC6-Mediated RhoA/ROCK1 Pathway
Authors: Mao Lichan , Ding Yin , Yu Dongrong , Yin Jiazhen , Yu Jin
Published: October 2022

Tetrandrine (Tet), a compound found in a traditional Chinese medicine, presents the protective effect for kidney function. Our study is aimed at clarifying the efficacy and underlying mechanism of Tet on podocyte injury. In this study, podocyte injury was induced in rats with adriamycin (ADR), and MPC5 podocytes were constructed with TRPC6 overexpression. We found that Tet treatment reduced the levels of proteinuria, serum creatinine, and blood urea nitrogen and increased plasma albumin levels in ADR-induced rats. Tet reduced intracellular Ca2+ influx and apoptosis in MPC5 podocytes overexpressing TRPC6. Tet downregulated the expression of renal TRPC6, RhoA, and ROCK1 and upregulated the expression of synaptopodin; meanwhile, it reduced calcineurin activity in vivo and in vitro. In conclusion, Tet protects against podocyte by affecting TRPC6 and its downstream RhoA/ROCK1 signaling pathway.
Oxidative-Damaged Mitochondria Activate GABARAPL1-Induced NLRP3 Inflammasomes in an Autophagic-Exosome Manner after Acute Myocardial Ischemia
Authors: Zhang Tiechun , Hou Dongyao , He Jianrong , Zeng Xue , Liu Ruixue , Liu Liangming , Li Tao , Xiao Yingbin , Ma Ruiyan , Huang He , Duan Chenyang
Published: October 2022

Objective. This study is aimed at identifying the potential diagnostic markers for circulating endothelial cells (CECs) for acute myocardial ischemia (AMI) and exploring the regulatory mechanisms of the selected biomarker in mitochondrial oxidative damage and vascular inflammation in AMI pathology. Methods. Utilizing the Gene Expression Omnibus dataset GSE66360, we scanned for differentially expressed genes (DEGs) in 49 AMI patients and 50 healthy subjects. To discover possible biomarkers, LASSO regression and support vector machine recursive feature elimination examinations were conducted. Using the GSE60993 and GSE123342 datasets and AMI rat models, the expression levels and diagnostic accuracy of the biomarkers in AMI were thoroughly verified. CIBERSORT was employed to evaluate the compositional patterns of 22 distinct immunological cell percentages in AMI according to combined cohorts. The oxidative-damaged mitochondria were detected by confocal microscopy observation of MitoTracker, ROS-DCFH-DA, and mCherry-GFP-LC3B. Results. In total, 122 genes were identified. The identified DEGs primarily contributed in arteriosclerosis, arteriosclerotic cardiovascular disorders, bacterial infectious disorder, coronary artery disease, and myocardial infarction. Nine features (NR4A2, GABARAPL1 (GEC1), CLEC4D, ITLN1, SNORD89, ZFP36, CH25H, CCR2, and EFEMP1) of the DEGs were shared by two algorithms, and GABARAPL1 (GEC1) was identified and verified as a diagnostic mitochondrial biomarker for AMI. Confocal results showed that there existed mitochondrial damage and oxidative stress in cardiac CMECs after AMI, and the blocked autophagy flux could be released by exosome burst in cardiac CMECs and blood CECs. Immune cell infiltration testing declared that elevated GEC1 expression in blood CECs was linked to the rise of monocytes and neutrophils. Functional tests revealed that high GEC1 expression in CMECs and CECs could activate the vascular inflammatory response by stimulating NLRP3 inflammasome production after AMI. Conclusion. Oxidative-damaged mitochondria in cardiac CMECs activate GEC1-mediated autophagosomes but block autophagy flux after AMI. The exfoliated cardiac CMECs evolve into abnormal blood CECs, and the undegraded GEC1 autophagosomes produce a large number of NLRP3 inflammasomes by exosome burst, stimulating the increase in monocytes and neutrophils and ultimately triggering vascular inflammation after AMI. Therefore, GEC1 in blood CECs is a highly specific diagnostic mitochondrial biomarker for AMI.
[Retracted] Effect of Orthodontic Combined with Implant Repair on Aesthetic Effect and Gingival Crevicular Fluid Factor in Patients with Dentition Defect and Periodontitis
Authors: Liu Min , Xu Zhengmao , Li Hao
Published: October 2022

In order to solve the effect of orthodontics combined with implant repair on the aesthetic effect and gingival crevicular fluid factor of patients with dentition defect and periodontitis, 60 patients who met the diagnostic criteria of chronic periodontitis were proposed. They were randomly divided into treatment group (taking Bushen Huoxue Guchi recipe for 3 courses while basic periodontal treatment) and control group (only basic periodontal treatment without taking any drugs). The experimental method of 30 cases in each group showed that PD, Al, and GI in the treatment group and control group decreased to varying degrees compared with those before treatment. The treatment group decreased significantly compared with the control group (P < 0.01). Chronic periodontitis is a common clinical periodontal disease, accounting for up to 95%, local stimulation, a variety of anaerobic bacteria infection, and periodontal plaque, and other factors may cause the occurrence of diseases. Routine treatment mainly includes upper gingival cleaning, lower curettage treatment, and equal root surface treatment. Although the clinical symptoms can be alleviated to a certain extent, the cause cannot be fundamentally excluded, leading to the disease progression in some patients and the formation of aggressive periodontitis and necrotizing periodontal disease.
[Retracted] Clinical Features and Risk Factors of Fever in Acute Gouty Arthritis
Authors: Huang Yan , Zhou Meiju , Yuan Fang
Published: October 2022

Objectives. This study aimed to investigate the clinical characteristics and risk factors of fever in hospitalised patients with acute gouty arthritis (AGA). Methods. The clinical data of 167 hospitalised patients with AGA who met the inclusion criteria were retrospectively analysed. The demographic, clinical, and medication data of patients with and without fever were compared, and risk factors associated with fever were identified via logistic regression analysis. Results. The incidence of fever in hospitalised patients with AGA was 31.1%, with low‐grade fever being predominant. Visual analogue scale (VAS) scores, white blood cell counts, neutrophil proportion, C‐reactive protein (CRP) levels, and erythrocyte sedimentation rate (ESR) were higher in the fever group than in the non‐fever group (P < 0.05 for all). In addition, the incidence rates of arthritis of single knee and polyarthritis were higher in patients in the fever group (P < 0.05). The proportion of patients who received betamethasone injection and combination therapy were higher in the fever group (P < 0.05). However, no significant differences were observed in age; sex; uric acid (UA) levels; and the incidence rate of hypertension, diabetes mellitus, cardiovascular disease, and renal function abnormalities between the two groups. Logistic regression analysis revealed that arthritis of single knee, polyarthritis, age of ≥65 years, CRP levels, and VAS scores were risk factors for concomitant AGA and fever. Among these factors, CRP levels and VAS scores were identified as independent risk factors (odds ratio [OR], 1.014 and 1.686, respectively; 95% confidence interval [CI], 1.004–1.025 and 1.115–2.549, respectively; P < 0.05 for both). Conclusion. The incidence of fever is high in hospitalised patients with AGA. Elderly patients, patients with arthritis affecting only one knee, and those with polyarthritis are predisposed to fever. In addition, the risk of developing fever increases with increasing VAS scores and CRP levels, and patients presenting with fever require enhanced anti‐inflammatory and analgesic therapy.
[Retracted] Translation and Expression of Professional Terms of Public Emergencies in External Reports
Authors: Zhu Zhanwei , Wang Chenhui
Published: October 2022

In order to better grasp the expression and translation methods of professional terms in the process of external reporting of public emergencies and grasp the characteristics and elements of the translation of publicity events, this study takes public emergencies as the research object and focuses on the application of English and Chinese professional terms and translation strategies in the process of external reporting. Therefore, based on the in‐depth analysis of the news reporting framework of public health emergencies, this paper deeply summarizes the application skills of professional terms in publicity texts, so as to provide a certain reference for further improving the translator’s ability to control the means of discourse cohesion and the level of discourse control of Chinese‐English professional terms in the translation of public health events.
Senkyunolide H Affects Cerebral Ischemic Injury through Regulation on Autophagy of Neuronal Cells via P13K/AKT/mTOR Signaling Pathway
Authors: Zhao Bei , Tang Ke-Cheng , Zhao Ying , Zhao Wang
Published: October 2022

Cerebral ischemia (CI) is associated with high global incidence and risk; therefore, its rapid and reliable therapeutic management is essential for protecting patients’ lives and improving health. Senkyunolide H (SH) is remarkably effective against phlebosclerosis, oxidation, and apoptosis. Blood-brain barrier is the main obstacle impeding the delivery of drugs and xenobiotics to brain areas. Drugs’ loading in nanoparticles can overcome the blood-brain barrier obstacle and thus directly and completely act on brain tissue, and such a loading can also change the half-life of drugs in vivo and lower the dosage requirement of drugs. In this study, we loaded the SH in lipid nanoparticles to improve its delivery to the brain for the therapy of CI. Thus, this study preliminarily analyzed the mechanism of SH-loaded nanoparticles in CI. The SH-loaded lipid nanoparticles were prepared and characterized with electron microscopy and PS potentiometery. The SH-loaded nanoparticles were intraperitoneally administered to CI-induced rats and brain tissue water content, and neuronal apoptosis and autophagy-associated proteins were determined. Our assays revealed SH-loaded nanoparticle’s ability to reduce nerve injury and brain tissue water content in rats with CI and inhibit the apoptosis and autophagy of their neuronal cells (NCs). Additionally, under intervention with SH-loaded nanoparticles, P13K/AKT/mTOR pathway-associated proteins in brain tissue of rats decreased. As the assay results showed, SH-loaded nanoparticles can suppress the autophagy of NCs through medicating P13K/AKT/mTOR pathway and lower apoptosis, thus delivering the effect of treating CI. Results of this study indicate SH-loaded nanoparticles as promising strategy for delivery SH to brain areas for treating CI.
A Dueling Deep Recurrent
Q
-Network Framework for Dynamic Multichannel Access in Heterogeneous Wireless Networks
Authors: Chen Haitao , Zhao Haitao , Zhou Li , Zhang Jiao , Liu Yan , Pan Xiaoqian , Liu Xingguang , Wei Jibo
Published: October 2022

This paper investigates a deep reinforcement learning algorithm based on dueling deep recurrent

Q

-network (Dueling DRQN) for dynamic multichannel access in heterogeneous wireless networks. Specifically, we consider the scenario that multiple heterogeneous users with different MAC protocols share multiple independent channels. The goal of the intelligent node is to learn a channel access strategy that achieves high throughput by making full use of the underutilized channels. Two key challenges for the intelligent node are (i) there is no prior knowledge of spectrum environment or the other nodes’ behaviors; (ii) the spectrum environment is partially observable, and the spectrum states have complex temporal dynamics. In order to overcome the aforementioned challenges, we first embed the long short-term memory layer (LSTM) into the deep

Q

-network (DQN) to aggregate historical observations and capture the underlying temporal feature in the heterogeneous networks. And second, we employ the dueling architecture to overcome the observability problem of dynamic environment in neural networks. Simulation results show that our approach can learn the optimal access policy in various heterogeneous networks and outperforms the state-of-the-art policies.
Evaluation of China’s High-Advanced Industrial Policy: A PMC Index Model Approach
Authors: Tian Ying , Zhang Kai , Hong Jiayi , Meng Fanglin
Published: October 2022

High-advanced industries upgraded by digital empowerment have gradually become an important support industry. Therefore, various provinces in China have issued relevant policies to support the prosperous of the digital economy and high-advanced industries. The collection and analysis of high-advanced industrial policy help to scientifically evaluate industrial policies and formulate scientific policy optimization paths. Based on a total of 168 high-advanced industrial policy documents from 26 cities in the Yangtze River Delta region from 2009–2021, this study adopts the PMC-Index model to evaluate the high-advanced industry policies in the digitalization context quantitatively. 12 representative high-advanced industry policy texts were selected for specific analysis. In addition, this study visualizes the measurement results of the internal structure and policy effectiveness of policies by PMC-Surface diagrams and then concludes that the design of high-advanced industry policies was relatively reasonable overall, with 11 policies rated as “Good Consistency” and only one “Acceptable Consistency.” The sample policies lack reasonable arrangements for different period plans, lack incentives, or have relatively single incentives. The policy influence among cities in the Yangtze River Delta urban agglomerations is small, and the integration trend is not apparent. There is a particular gap in the scores between Shanghai, Zhejiang, Jiangsu, and Anhui province. This study provides references and suggestions for formulating and revising high-advanced industrial policies.
Adab as a Way of Life: Towards an Ethical Turn in History
Authors: Gubara Dahlia , Wick Alexis
Published: October 2022

Like ancient philosophy in Pierre Hadot’s conception, the polysemic notion of adab in the Arabic-Islamic tradition was a way of life, and not merely a scholarly discipline or cultural field. This essay explores this proposition in reference to the life and work of the Palestinian historian Ṭarīf al-Khālidī, where adab has been a central locus of reflection. Although steeped in present-day historical, literary, and philosophical discussions, we argue that al-Khālidī’s approach has an uncanny resemblance to classical conceptions of adab and thereby invites a re-examination of current scholarly practices, presaging an ethical turn in the study of history.
Al-Balādhurī’s Prophet’s Biography: Narrative in Service of Politics
Authors: Rihan Mohammad A.
Published: October 2022

The monumental multi-volume work Ansāb al-ashrāf, authored by Aḥmad b. Yaḥyā al-Balādhurī, represents an intellectual edifice recognized by many scholars. However, this paper endeavors to discuss in depth the first volume of it, which al-Balādhurī dedicated to the life of the Prophet Muḥammad, and attempts to show that the underlying reasons for writing another biography of the Prophet—in an age where the Sīrah of the Prophet was well established—were mainly political and personal, linked in particular to the rule of the ʿAbbāsids. It aimed to legitimize ʿAbbāsid rule by systematically and subtly enhancing the role of ʿAbbāsid symbols and ancestry in the formation of early Islam, mainly by linking the eponym of the ʿAbbasid dynasty, al-ʿAbbās b. ʿAbd al-Muṭṭalib, to a positive image of the Prophet.
Emotion Words in Spanish: Lexical Selection, Affective Dimensions, Sex and Age Differences
Authors: Díaz José-Luis , Barraza Georgina , Hernández-Fuentes Eduardo , Jiménez Said
Published: October 2022

This study proposes a method for selection and analysis of words that refer to emotions. A comparison of 380 synonyms corresponding to the six basic emotions in 15 Spanish thesauri resulted in 43 terms. Respondents of an online survey (n = 980) stated whether they recognized and used each word and how often they experienced the designated emotion, which resulted in 23 terms. The correlation matrix for the selected terms frequencies and a multivariate analysis of the data revealed three affective dimensions: anger, fear, and satisfaction. The frequency for the terms was higher for women, who reported more panic and irritation than men. In both, the frequency of the negative emotions of fear and sadness decrease with age, while pleasure, satisfaction, and indignation increase. The results suggest the existence of three affective dimensions (anger/repulsion, fear/sorrow, and satisfaction/admiration), which have been recognized in neurobiological, ecological, ethological, and evolutionary models.
Procedure for Identifying Metaphorical Scenes (pims): A Cognitive Linguistics Approach to Bridge Theory and Practice
Authors: Falck Marlene Johansson , Okonski Lacey
Published: October 2022

Over the past decades, several procedures have been developed to identify metaphors at the lexical level. However, because language is complex, there may not be one superior metaphor identification procedure that applies to all data. Moreover, metaphor identification inevitably involves decisions on linguistic form that may not work equally well with all linguistic frameworks. We introduce a Procedure for Identifying Metaphorical Scenes (pims) reflected and evoked by linguistic expressions in discourse. The procedure is a prerequisite for the identification of metaphorical meaning that extends over phrases or longer stretches of text other than those defined as lexical units in current metaphor identification procedures and better reflects the Cognitive Linguistic (cl) view that linguistic meaning is equal to complex conceptualizations (Langacker, 2002, 2010), embodied (Gibbs, 2006b), and simulation-based (Bergen, 2012). It takes the scenes evoked by the context into account and focuses on the experiences that are coded by the linguistic constructions.
Multidisciplinary Difficult Airway Team Characteristics, Airway Securement Success, and Clinical Outcomes: A Systematic Review
Authors: Pandian Vinciya , Ghazi Talha U. , He Marielle Qiaoshu , Isak Ergest , Saleem Abdulmalik , Semler Lindsay R. , Capellari Emily C. , Brenner Michael J.
Published: October 2022

Objective:

To investigate whether implementation of a multidisciplinary airway team was associated with improvement in (1) rate of successful airway securement at first attempt; (2) time to secure airway; and (3) overall complication rate in patients with a difficult airway, as compared with usual care.

Data Sources:

Ovid Medline, Embase, Scopus, Cochrane Central, and CINAHL databases.

Review Methods:

Systematic review of literature on inpatient multidisciplinary team management of difficult airways, including all studies performed in inpatient settings, excluding studies of ventilator weaning, flight/military medicine, EXIT procedures, and simulation or educational studies. DistillerSR was used for article screening and risk of a bias assessment to evaluate article quality. Data was extracted on study design, airway team composition, patient characteristics, and clinical outcomes including airway securement, complications, and mortality.

Results:

From 5323 studies screened, 19 studies met inclusion criteria with 4675 patients. Study designs included 12 quality improvement projects, 6 cohort studies, and 1 randomized controlled trial. Four studies evaluated effect of multidisciplinary difficult airway teams on airway securement; all reported higher first attempt success rate with team approach. Three studies reported time to secure the difficult airways, all reporting swifter airway securement with team approach. The most common difficult airway complications were hypoxia, esophageal intubation, hemodynamic instability, and aspiration. Team composition varied, including otolaryngologists, anesthesiologists, intensivists, nurses, and respiratory care practitioners.

Conclusion:

Multidisciplinary difficult airway teams are associated with improved clinical outcomes compared to unstructured emergency airway management; however, studies have significant heterogeneity in team composition, algorithms for airway securement, and outcomes reported. Further evidence is necessary to define the clinical efficacy, cost-effectiveness, and best practices relating to implementing difficult airway teams in inpatient settings.
Features of an Atypical RSV Surge During the COVID-19 Pandemic
Authors: Alrayes Tabatha , Wait Andrea , Spencer Priya , Merolla David M , Lampe Kirby , Salimnia Hossein , Kannikeswaran Nirupama
Published: October 2022

This study describes the clinical features, severity, and outcomes in children <5 years of age with respiratory syncytial virus (RSV) infection during an atypical summer surge during the coronavirus disease 2019 (COVID-19) pandemic. Although timing was uncharacteristic, clinical features and illness severity were representative of a typical RSV season. Co-infection with SARS-CoV-2 was low.
Characterization of polyester composites reinforced with natural fibers from Luffa cylindrica
Authors: Paula Edgley AdeO , Melo Rafael Rodolfo de , Silva Manoel Qd , Paula Yara Ld , Pimenta Alexandre S , Souza Joana Alice Gd , Oliveira Ramona RAd , Paula Edjane AdO , Medeiros Neto Pedro Nd , Rodolfo Francisco
Published: October 2022

Concerns about global warming, environmental preservation, overexploitation of raw materials, and the development of new technologies are increasing. This has been attracting increasing interest in composites reinforced with natural fibers, mainly to replace synthetic materials. In this context, the present research work aimed to demonstrate the technical feasibility of the production of polyester-polymeric-matrix composites reinforced with fibers of Luffa cylindrica and a hybrid with fiberglass. The composites' physical properties (density, moisture content, water absorption, and thickness swelling) and mechanical properties (tensile, bending strength, and Rockwell hardness (RH)) were assessed. The composites were produced through cold pressing in a closed mold. The experiment was performed according to an entirely randomized design with two replicates per treatment and the means were compared by the Tukey test at 95% probability. The results demonstrated that the reinforcement with the Luffa fibers promoted a decrease in the density of the composites, with a minimum value of 1.01  g cm−3. In the assays of tensile strength, the reinforced composite presented a value of 10.20 MPa for this property, while for the bending strength, the value was 18.04 MPa. When the Luffa fibers were employed in the hybrid composite, the bending strength reached 105.12 MPa. In general, the composites reinforced with the plant fibers and the hybrid had physical and mechanical properties permitting their employment for several end-uses, according to the characteristics of each one. The new composites are partially biodegradable, sustainable, and light.
Assessing Sleep Quality in Older Adults: A Comparison of Three Measurement Approaches
Authors: Berkley Amy S. , Carter Patricia A.
Published: October 2022

Discrepancies between subjective and objective sleep measures have been reported for some time; however, it is critical to consider the implications of inaccurate or incomplete sleep assessment for frail older adults who are struggling to maintain independence. To compare sleep assessment methods, we collected objective sleep measurements, subjective measures via self-report sleep surveys, and qualitative data through semi-structured audio-recorded interviews, from five older adults who self-reported sleep problems while living in a retirement community in the southwestern US. Participants’ objective sleep and qualitative narratives were congruent, but self-report measures failed to capture several unique sleep problems identified in the sample. A sleep assessment tool specifically designed to measure older people's sleep experiences could provide more accurate and sensitive data.
Network pharmacology and bioinformatics analyses identify the intersection genes and mechanism of Huang Bai for recurrent aphthous stomatitis
Authors: Tang Lulu , Huang ling , Lai yingtao
Published: October 2022

Recurrent aphthous stomatitis (RAS) are complex inflammatory diseases caused by multi-factors, which severely impact patient quality of life. However, there is still no effective treatment method for RAS without side effects. Traditionally, Cortex Phellodendri known as “Huang Bai” was used to treat RAS for antibacterial and anti-inflammatory properties in China. Network pharmacology methods and bioinformatics analysis were utilized to search and fish incorporating target. Network analysis and silico validation were used to discover the pharmacological mechanisms of “Huang Bai” for the treatment of RAS. A total of 25 active ingredients in HB, 200 drug targets, and 578 differentially expressed genes (DEGs) between Recurrent aphthous stomatitis and normal samples were obtained. The Gene Ontology enrichment analysis revealed that the immune response was the most significantly enriched term within the DEGs. The KEGG pathway analysis identified 60 significant pathways, most of which involved in the inhibition of inflammation and regulation of immunological response. The functions are dependent on a multi-pathway, particularly the TNF signaling pathway and the HIF-1 signaling pathway. We identified six hub genes in the PPI network, most of which were validated as highly expressed in oral ulcers by DiseaseMeth databases. In addition, molecular docking displayed that the primary molecule combined well with the key targets. “Huang Bai” contains potential anti-RAS active compounds. This study reflects the multi-component multi-target multi-pathway action characteristics of “Huang Bai.” Our study provides potential biomarkers or treatment targets for further research.
“The Stigma is what you do”: Examining the Relationship Between Occupational Stigma and Worker Outcomes in the Aged Care Context
Authors: Manchha Asmita V. , Way Kïrsten A. , Thai Michael , Tann Ken
Published: October 2022

Negative social evaluations about aged-care work continue to discredit those who perform this type of work. Drawing on ‘dirty work’ literature from the field of management and stigma theory from the field of psychology, this study examines occupational stigma in the context of aged-care work and its relationship with negative outcomes for people who work in aged care. Findings from a path analysis revealed that aged-care workers (n = 185) who ascribe occupational taints and poor occupational conditions with aged-care work perceive aged-care work as being stigmatized, and in turn, are more likely to internalize this stigma. Through this process of perceiving and internalizing occupational stigma, aged-care workers experience greater psychological distress, job dissatisfaction, and turnover intentions. This research fills a void within the gerontology literature regarding the psychological processes underlying how occupational stigma may come to negatively impact this workforce. Findings offer practical implications for policy reform and managerial training.
Rules for Interventional Radiology
Authors: Kachura John R.
Published: October 2022

During the hands-on teaching of Interventional Radiology (IR) to Residents and Fellows, certain learning tips or guiding statements are often repeated. Over the past two decades, these tips have evolved into the “Rules for Interventional Radiology.” Relying on humour and the technical and foundational principles of our subspeciality, it is hoped that these Rules for IR provide helpful guidance to learners and practising Interventionalists in their daily work.
The Role of Sexual Scripts in the Relationship Between Pornography Use and Sexual Coercion
Authors: Marshall Ethan A. , Miller Holly A.
Published: October 2022

Decades of research have examined the association between pornography use and sexual coercion, with the most significant relationships found between more deviant genres of pornography use and sexual violence. However, researchers have yet to provide a comparable body of research examining the theoretical mechanism of this association. One theory that has shown promise in explaining the association between certain variables of pornography use and sexual coercion is the sexual script theory. In this theory, scripts can best be understood as a mechanism through which society defines and disseminates what is acceptable, desirable, and pleasurable sexual conduct. Studies examining the application of the sexual script theory to the association between pornography use and sexual coercion have found that pornography use has a significant indirect effect on sexual coercion and correlates of sexual coercion through sexual scripts. The current study sought to extend this line of inquiry by examining the relationship between pornography use, sexual scripts, and sexual coercion. A structural equation model examining direct and indirect effects of sexual scripts and pornography use on sexually coercive behaviors was run using a sample of 390 college-aged males. Results of the study indicated there were significant direct and indirect effects in the model. Specifically, pornography use, while not directly related to sexually coercive behaviors, had a significant indirect effect on sexual coercion through sexual scripts. These results further support the use of the sexual scripts theory to help explain the relationship between pornography use and sexual coercion.
Dublin Anti-Bullying Self-Efficacy Models and Scales: Development and Validation
Authors: Sargioti Aikaterini , Kuldas Seffetullah , Foody Mairéad , Viejo Otero Paloma , Kinahan Angela , Canning Colm , Heaney Darran , O’Higgins Norman James
Published: October 2022

Literature on anti-bullying programs shows a growing consensus about promoting victims and bystanders’ self-efficacy against bullying, but provides no theoretical model nor measurement scale to assess the extent of achieving this aim. The current research aims to address these theoretical and empirical gaps by proposing the Dublin Anti-Bullying Self-Efficacy Models and Scales, using a convenience sample of 14-year-old students in Ireland ( N = 1,100). After establishing both content and face validity, four separate scales were tested to measure anti-bullying self-efficacy beliefs among offline victims (20-item), online victims (20-item), offline bystanders (20-item), and online bystanders (20-item). Thereafter, four separate exploratory factor analyses of the scale items were followed by reflective measurement analyses of their internal consistency and construct (convergent and discriminant) validity. Results indicated sufficient psychometric properties of each scale measuring five dimensions of anti-bullying self-efficacy: recognition, emergency comprehension, responsibility, knowledge, and intervention. Further research is needed to test the proposed model and scale for assessing effectiveness of an anti-bullying program in promoting self-efficacy beliefs.
Daily Associations Between Trauma-Related Mental Contamination and Use of Specific Coping Strategies: Results of a Daily Monitoring Study
Authors: Tipsword Jordyn M. , Southward Matthew W. , Adams Anita M. , Brake C. Alex , Badour Christal L.
Published: October 2022

Mental contamination (MC)—a sense of dirtiness experienced without contacting an identifiable pollutant—is a distressing and enduring experience among many survivors of sexual trauma. MC has been linked to more frequent use of avoidant coping behaviors (e.g., washing behavior, substance use, binge eating) and approach coping. However, it is unclear if specific approach and avoidant coping strategies are more consistently related to perseverative experiences of trauma-related MC, if the use of certain strategies predicts changes in MC, and if fluctuations in MC predict the use of certain strategies. The present study evaluated contemporaneous and prospective relationships between sexual trauma-related MC and use of 11 specific coping strategies among 41 women with a history of sexual trauma using an experience sampling design. Women completed twice-daily assessments of coping strategy use and MC for 14 days. Between-persons, women reporting more intense MC on average reported more frequent use of distraction, denial, giving up, self-blame, thought suppression, washing behavior, emotional processing, and emotional expression than those experiencing less intense MC. Within-person increases in MC were associated with more frequent concurrent use of all coping strategies except seeking support. Lastly, within-person increases in MC predicted more frequent use of giving up, substance use, and seeking support at the next assessment and within-person increases in substance use predicted less severe MC at the next assessment. Future work should aim to identify factors influencing the selection and/or quality of use of these specific coping strategies among individuals experiencing MC.
Alternative Compensation, Teacher Performance, and Policy Implications: An Equity Theory Approach
Authors: Prieto Leon C. , Phipps Simone , Vincent Vinod
Published: October 2022

This paper proposed equity theory as a potential theoretical framework that may be considered to underpin an alternative compensation model that can work for teachers in the K-12 system in the United States. This approach may help with ensuring teacher performance and retention. The current compensation system adopted in many districts needs to be re-designed and should consider introducing an alternative compensation model to boost performance and to retain high-quality teachers in the nation’s classrooms.
Operation diagnosis for centrifugal pumps using stator current-based indicators
Authors: Han Yuejiang , Yuan Jianping , Luo Yin , Zou Jiamin
Published: October 2022

Motor current signature analysis (MCSA) used in the diagnosis of centrifugal pumps has become a hot topic due to its non-intrusive and cost-effective nature. Yet, traditional current-based diagnosis methods show limitations as massive computation and power frequency interference. Moreover, most of them focus on the fault detection, fewer discuss the applications in operation evaluation. Therefore in this article, the hydro-mechanical-electric coupling effect that exists in the induction motor-centrifugal pump system is analyzed systematically. On this foundation, novel indicators that can reflect the harmonic distortion and noise proportion of stator current signals, and further indicate the hydraulic stability and operation status are proposed. Theoretical and experimental analysis support this paper, and results have demonstrated that our proposed indicators can indicate the operation change, identify the optimal operation region, and reflect the development of cavitation for centrifugal pumps. These indicators have the advantages of easy calculation and identification, therefore can be conveniently compared with accepted standards and enable immediate remedial actions to be implemented to ensure the stable operation.
Waste granite powders as fillers in epoxy coatings: A case study in a car repair workshop
Authors: Chowaniec-Michalak Agnieszka , Czarnecki Sławomir , Sadowski Łukasz
Published: October 2022

Epoxy coatings of floors are a very good solution for car repair workshops. Epoxy coatings provide the floor with resistance to oil, fuel, and grease staining. The floor surface is very easy to clean. To support sustainable development, a filler in the form of waste granite powder was added to the epoxy coating. In a car repair workshop, an epoxy coating of the floor was made according to the recipe previously developed in laboratory tests. The pull-off strength of the concrete substrate was tested before and after the mechanical treatment of concrete surface. The pull-off strength of the epoxy coating was also tested. The obtained results were compared with the laboratory results. It has been proved that the waste granite filler does not deteriorate the pull-off strength of the epoxy coating and thus its durability. The waste granite powder can be successfully applied as a filler in real epoxy coatings of floors.
CFD analysis and experimental investigation to determine the flow characteristics around NACA 4412 airfoil blades at different wind speeds and blade angles
Authors: Afshari Faraz , Khanlari Ataollah , Sözen Adnan , Tuncer Azim Doğuş , Ates Ibrahim , Sahin Bayram
Published: October 2022

An aerodynamically efficient blade is one of the prime necessities to extract the maximum mechanical power from a wind turbine. A number of researches are available in the literature studying blade design and configuration to improve aerodynamic characteristics of horizontal axis wind turbines. Less attention, however, has been devoted to wind turbines in terms of simultaneous optimization of blade and airfoil angles. The present study is important for the aerodynamic design and manufacturing of wind turbine blades. In this regard, various blade angles have been numerically simulated to determine the optimum blade angle. In addition to numerical analysis, experimental tests have been done to investigate NACA 4412 blade angle. As a result of this study, it was observed that blade angle in the range of 5°–10° showed the best performance among the tested various blade angles.
Sliding mode control based impact angle constrained guidance with predefined convergence time
Authors: Majumder Kakoli , Kumar Shashi Ranjan
Published: October 2022

This paper proposes predefined-time convergent guidance schemes that can drive the pursuer on a collision course corresponding to the target interception from a pre-specified impact direction, irrespective of initial engagement geometries. The target interception at the desired impact angle is first transformed into a problem of controlling the line-of-sight angle and its rate. Then, guidance commands are derived using sliding mode control (SMC) to ensure the convergence of corresponding errors to zero within a predefined time. A nonlinear disturbance observer is used to estimate the target’s maneuver, and the estimation error is treated as an uncertainty while rejecting its effect by virtue of SMC. Guidance commands are also derived for the case where the target maneuver is completely unknown except for its upper bound. It was shown that the gain could be selected based on the maximum bound on target maneuver to enforce sliding mode on the chosen surface, and thus guarantees target interception at a pre-specified impact angle, provided the closing speed of the engagement is positive. Owing to the use of a nonlinear framework while deriving pursuer guidance commands, the proposed guidance strategies remain valid even for engagements with large initial deviations where schemes based on linearized dynamics may fail or have degraded performance. The efficacy of the proposed guidance methods is validated through simulations for the pursuers having constant speed and time-varying speed, for various engagement geometries. The results of proposed strategies are compared with those of existing guidance and shown to be superior.
Plant dependency and risk management in the Andean Puna during the Mid to Late-Holocene
Authors: Pintar Elizabeth , Fernanda Rodríguez María
Published: October 2022

The archeology of the Puna, a high elevation desert in South America, gives us a long-term perspective on the role of wild plants in people’s diets during the Holocene. We explore the impact of aridification on the use of edible wild plants among desert people through the study of macrobotanical remains. Our goal is to examine the variation in plant dependency and risk management strategies used over time, in particular during the drought of the Middle Holocene (ca. 8700–4500 BP). The macrobotanical record suggests the use of risk-averse strategies in order to cope with unpredictable resource productivity. Hunter-gatherers relied on carbohydrate rich resources from the vega wetlands and tolar shrublands, such as roots and tubers, as well as low-ranked seeds, stems, leaves, and fruits. They also obtained non-local edible plants by strengthening ties and forming safety nets with groups living in different ecozones that were not subject to the same resource fluctuation. Social interaction with areas lying beyond the ecological boundaries of the Puna has a longstanding tradition in this area beginning in the Early Holocene, and was likely a means of providing food security to populations whose subsistence depended mainly on camelid hunting, and eventually camelid pastoralism. A notable increase in that interaction began during the Late-Holocene, which was a period of lesser aridity, with the introduction of corn and quinoa.
The militarization of digital surveillance in post-coup Zimbabwe: ‘Just don’t tell them what we do’
Authors: Munoriyarwa Allen
Published: October 2022

While a large body of research has documented and theorized digital surveillance practices in various political contexts, little has been done to investigate the growing trend of military-driven digital surveillance practices in semi-authoritarian regimes. In this article, I use the case of the surveillance practices of the Zimbabwe Defence Forces to argue that scholarship needs to (re)evaluate this emerging trend. The article has three aims: first, it explores military-driven surveillance capabilities, the circulation of such capabilities and the surveillance tactics emerging in the semi-authoritarian context of Zimbabwe. Second, it examines the interface of factionalism and politics within the Zimbabwe Defence Forces and how this influences quotidian military-driven digital surveillance practices. Third, it locates military-driven surveillance practices within a growing and complex global political economy of trade in surveillance technologies that is centred on China. In doing so, the article helps locate a largely neglected but increasing practice of military-driven surveillance that is incrementally reconfiguring surveillance practices and architectures in semi-authoritarian regimes. Such a form of surveillance provides gateways for human rights abuses and shrinks the civilian spaces of protest and engagement, leading to digital authoritarianism. The article therefore calls for greater scrutiny of the emerging practice of military-driven digital surveillance in semi-authoritarian political contexts.
Right atrioventricular valve dysplasia in a meerkat
Authors: Cham Tat-Chuan , Desprez Isabelle , Gupta Ashish , Aburto Enrique
Published: October 2022

A 7-y-old, captive, intact female meerkat ( Suricata suricatta) was presented with lethargy, decreased appetite, dyspnea, and distended abdomen. At autopsy, the right atrium was markedly dilated, and the right atrioventricular valve (RAV) was dysplastic with shortened or absent chordae tendineae and direct attachment of the valve to the papillary muscles, which, in turn, were fused and abnormally positioned. The right ventricle was considered to be hypertrophied. Also present were hydrothorax, ascites, atelectasis, and hepatic congestion. A diagnosis of RAV dysplasia was made. Histologic findings included hypertrophy of cardiomyocytes and marked centrilobular hepatic congestion and hemorrhage, which were consistent with right-sided heart failure.
The Continuity of Cancer: Children and Adolescent’s Experiences of Ending Cancer Treatment – A Systematic Review
Authors: von Werthern Martha , Grigorakis Georgios , Sweet Rebecca , Soon Kristina
Published: October 2022

As the research and treatment of childhood cancer steadily progresses, so has the interest in children’s needs, not only throughout such treatment but also following completion. Whilst there is increased literature focussing on the long-term psychosocial impact of treatment completion, little is currently known about how children and young people (CYP) experience the more immediate end of their cancer treatment. The current review seeks to examine CYP’s experiences of the end of their cancer treatment . Sixteen studies were retrieved using a systematic search strategy across five databases, all of which used qualitative methodology. Thematic synthesis was chosen to analyse the data. Four overarching themes were generated, which encompassed ‘ the continuity of cancer’, ‘ ambivalence of needs’, ‘ making sense of the cancer experience’ and ‘ sense of self following the ending’. The end of treatment is a time of complexity for CYP, yet it is currently largely overlooked. In order to scaffold these endings for CYP, increased emphasis and thought needs to be placed on the end of treatment and the support that is provided within it.