bluuebunny/crossref_metadata_2025 huggingface dataset:
Colorectal carcinoma: Evaluation of systemic values of interleukin-1 and interleukin-33 in patients with and without thrombocytosis
Authors: Jocic Miodrag , Gajovic Nevena , Jurisevic Milena , Jovanovic Marina , Zdravkovic Natasa , Arsenijevic Nebojsa , Vukovic-Dejanovic Vesna , Maric Veljko , Milev Bosko , Jovanovic Milan
Published: October 2019

Background/Aim. Reactive thrombocytosis, as a paraneoplastic syndrome, is often observed in cancer patients. A variety of tumor-related humoral factors and cytokines con-tribute to tumor-stimulated thrombopoiesis. However, the exact role of these cytokines in the pathogenesis of thrombocytosis remains unclear. The aim of this study was to analyze systemic values of cytokines and clinical-pathological characteristics in colorectal carcinoma (CRC) patients with and without thrombocytosis. Methods. Fifty nine CRC patients were involved in this study and divided into two groups according to the number of platelets. We recorded and analyzed the data about: age, gender, size of the cancer, localization, metastasis, vascular or lymph vessel invasion, nuclear grade, histological differentiation rate, tumor, nodus, metastasis (TNM) stage and concentration of cytokines [interleukin (IL)-1, IL-33, IL-12, IL-17 and interferon (IFN)-?] in both groups. Results. CRC patients with thrombocytosis had significantly higher nuclear grade of the cancer (p = 0.002); higher percentage of detectable metastatic lesions in the liver (p = 0.002), lung (p = 0.001), peritoneal carcinomatosis (p = 0.001), detectable invasion of blood (p = 0.012) and lymph vessels (p = 0.010). Concentrations of tumor markers [alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA19-9)] and se-rum values of IL-1 a nd I L-33 were significantly higher in CRC patients with thrombocytosis. IL-1/IL-12 (p = 0.016), IL-1/IFN-? (p = 0.007), IL-1/IL-17 (p = 0.006), IL-33/IL- 12 (p = 0.001), IL-33/IFN-? (p = 0.001), IL-33/IL-17 (p = 0.002), and IL-33/IL-1 (p = 0.006) ratios were significantly higher in CRC patients with thrombocytosis in comparison to CRC patients without thrombocytosis. Analysis of Receiver Operating Characteristic (ROC) curves showed that values of IL-1 [area under curve (AUC) = 0.718; 95% confidence interval (CI): 0.567?0.868; sensitivity 69.2%, specificity 62.9%] and IL-33 (AUC = 0.763; 95% CI: 0.614? 0.911; sensitivity 84.6%, specificity 65.7%)], could be serve as possible markers for paraneoplastic thrombocytosis in CRC patients. Conclusion. IL-1 a nd I L-33 significantly correlated to high thrombocyte number in patients with more aggressive CRC.
Who Should Select New Employees, Headquarters or the Unit Manager? Consequences of Centralizing Hiring at a Retail Chain
Authors: Deller Carolyn , Sandino Tatiana
Published: October 2019

We examine how changing the allocation of hiring decision rights in a multiunit organization affects employee-firm match quality, contingent on a unit's circumstances. Our research site, a U.S. retail chain, switched from a decentralized hiring model (hiring by business unit managers—in our case, store managers) to centralized hiring (in this study, by the head office). While centralized hiring can ensure that enough resources are invested in hiring people aligned with company values, it can also neglect the unit managers' local knowledge. Using difference-in-differences analyses, we find that the switch is associated with relatively higher employee departure rates and, thus, poorer matches if the business unit manager has a local advantage; that is, if the store serves repeat customers, serves a demographically atypical market, or poses higher information-gathering costs for headquarters. In these cases, the unit manager may be more informed than headquarters about which candidates best match local conditions.

Data Availability: The analyses presented in this study are based on data shared by a U.S. retail company. The data are confidential, according to a nondisclosure agreement between the company and the authors.
Sistema de indicadores de gestión de la sección de evaluación de desempeño
Authors: Pirona Jesús Antonio
Published: October 2019

La investigación fue de tipo descriptiva con el objetivo de analizar el sistema de indicadores de gestión de la sección de evaluación de desempeño de la secretaria de salud del Estado Falcón. Los resultados indican que a pesar de cumplir con las actividades que contempla el proceso de evaluación de desempeño del personal dentro de los lapsos que corresponden, la falta de planificación del personal de manera individual, podría afectar el interés colectivo de la sección en caso de presentarse alguna eventualidad no prevista, que retrase el desarrollo de las labores, como lo es el caso de la atención al público y las asesorías.
Cuadro de Mando Integral en administración financiera hospitalaria
Authors: García-Loor Ana del Rocío
Published: October 2019

La investigación tuvo por objetivo analizar los indicadores basado en el Cuadro de Mando Integral para el departamento de compras del Hospital Verdi Cevallos de la ciudad de Portoviejo – Ecuador, desde una tipo descriptiva y no experimental, la población fue de 11 personas que laboran en el departamento de compras. La necesidad de crear mecanismos que permitan estudiar la relación con los proveedores, de ese modo, se puede garantizar que exista una relación donde establezca la sinergia necesaria en beneficio de los servicios que deben recibir los clientes finales. Se deben implementar planes de formación en cuadro de mando integral; además se deben incorporar temáticas que contribuyan al crecimiento integral de las personas y estar así; en concordancia con lo planteado anteriormente.
Perspectivas del cuadro de mando integral en cooperativas de transporte
Authors: Portacio-Rodríguez Carlos Alberto
Published: October 2019

La actual investigación tiene por objetivo analizar las perspectivas del cuadro de mando integral en cooperativas de transporte, específicamente en la cooperativa servicios el prado. El estudio se enmarcó dentro de una investigación de carácter descriptivo. Entre las principales conclusiones se tiene que aplicar el cuadro de mando integral, previo análisis del mismo, a fin de lograr los objetivos previstos en el mismo, mediante el desarrollo de indicadores, planes de acciones, que deben ser realizados por los miembros de la empresa. La importancia es que el cuadro de mando integral contribuye a la toma de decisiones en los procesos internos, mejoramiento del desempeño del personal, verificación de la satisfacción de los clientes, control de las actividades financieras y no financieros de la organización.
Direccionamiento empresarial mediante un plan estratégico organizacional
Authors: Albarran-Camacho Rodolfo Antonio
Published: October 2019

La investigación se basó en diseñar un plan estratégico para Inversiones PRIGO, C.A., con el propósito de definir un direccionamiento estratégico que guíe el desarrollo de acciones que permitan a la organización alcanzar y mantener una posición competitiva en un mercado tan reñido como en el que se desenvuelve, con un tipo de investigación descriptiva, el diseño de la investigación se considera de campo, documental y transeccional. Se formularon dieciocho (18) estrategias para la empresa y mediante una matriz de evaluación se realizó una jerarquización de las mismas, para determinar su grado de importancia. Finalmente, se diseñó un plan de acción para un horizonte de cinco años (periodo 2013 – 2018), estructurado en área, objetivos corporativos, estrategias, tiempo de ejecución, metas, responsables, recursos y proyectos estratégicos.
Elementos caracterizadores en la formación universitaria del diseñador grafico
Authors: Oyarvide-Estupiñan Paul Alejandro
Published: October 2019

Este artículo, siguió como objetivo estudiar los elementos caracterizadores en la formación universitaria del diseñador gráfico. La metodología siguió un Se distinguió una metodología cualitativa y documental. El corpus del estudio lo constituyeron materiales directos de tipo bibliográfico y documental. La hermenéutica, es el método que permitió realizar el análisis de las teorías. Los resultados, indican que la formación universitaria del diseñador gráfico, cubiertas en todas sus etapas, les permitirá el uso de las técnicas de expresión gráfica, oral y escrita, y la aplicación de formatos de comunicación claros y consistentes.
Elementos determinantes del desarrollo gerencial empresarial
Authors: Chamorro-Quiñonez Joshelyn Germania
Published: October 2019

El presente trabajo tuvo como propósito evaluó los elementos determinantes del desarrollo gerencial administrativo en empresas del Cantón de Loja. El estudio siguió un paradigma descriptivo y el diseño no experimental y de campo. La población fue de 80 gerentes empresariales de la región.  La encuesta fue la técnica utilizada para la recolección de los datos a partir de un instrumento tipo cuestionario con tres alternativas de respuestas: Siempre, algunas veces y nunca. La técnica de análisis fue la estadística frecuencial y descriptiva con medidas de tendencia central. Entre sus conclusiones se pudo constatar  que más del  55% del total de los gerentes encuestados, consideraron que algunas veces ejecutan los elementos de capacitación, planeación y desarrollo de carrera y la evaluación del desempeño, todo ello a partir de la realización de algunas actividades durante el proceso del cumplimiento de sus  funciones básicas que deben cumplir los gerentes empresariales.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF STAD UNTUK MENINGKATKANPRESTASI BELAJAR IPA
Authors: Warta Nyoman
Published: October 2019

Penelitian ini bertujuan untuk meningkatkan prestasi belajar IPA siswa kelas IX-B SMP Negeri 4 Banjar melalui penerapkan model pembelajaran kooperatif  STAD (Student Team Achievement Divison). Penelitian ini dirancang dalam dua siklus. Rancangan tiap-tiap siklus terdiri dari empat tahapan yaitu; perencanaan, tindakan, dan refleksi. Subjek penelitian adalah siswa kelas IX-B SMP Negeri 4 Banjar semester ganjil tahun pelajaran 2015/2016 berjumlah 27 orang. Pada pembelajaran prasiklus siswa yang mencapai ketuntasan 66,67% dan siswa yang tidak tuntas 33,33%. Data prestasi belajar IPA melalui tes prestasi belajar IPA pilihan ganda dan isian. Data prestasi belajar IPA dianalisis secara deskriptif dan dinarasikan secara kualitatif. Hasil penelitian pada siklus-1 adalah: (1) nilai terendah 60,00 dan nilai tertinggi 90,00, (2) rata-rata kelas76,30, dan (3) siswa yang tuntas 81,48% (belum memenuhi ketuntasan klasikal ≥ 85% berdasarkan KKM 70,00. Hasil penelitian pada siklus-2: (1) nilai terendah 60,00 dan nilai tertinggi 95,00, (2) rata-rata kelas77,78, dan (3) siswa yang tuntas 88,89% (memenuhi ketuntasan klasikal ≥ 85% berdasarkan KKM 70,00).  Berdasarkan analisis hasil penelitian dari siklus-1 ke siklus-2 dapat disimpulkan bahwa, penerapan model pembelajaran kooperatif STAD dapat meningkatkan prestasi belajar IPA siswa kelas IX-B SMP Negeri 4 Banjar semester ganjil tahun pelajaran 2015/2016.
STRATEGI PEMBELAJARAN BERORIENTASI KONSEP TRI HITA KARANA PADA FAKULTAS BAHASA DAN SENI UNIVERSITAS PENDIDIKAN GANESHA
Authors: Sriasih Sang Ayu Putu , Budasi I Gede , Nitiasih Putu Kerti , Wisudariani Ni Made Rai
Published: October 2019

Penelitian ini bertujuan memperoleh data mengenai keterpahaman civitas akademika terhadap landasan Tri HIta Karana sebagai bagian dari visi Fakultas Bahasa dan Seni dan  strategi pembelajaran berorientasi konsep Tri Hita Karana oleh para dosen di lingkungan Fakultas Bahasa dan Seni. Penelitian ini menggunakan rancangan deskriptif yang bersifat expostfacto dengan subjek penelitian para dosen, mahasiswa, dan pegawai di lingkungan Fakultas Bahasa dan Seni, Undiksha. Data penelitian dikumpulkan dengan metode studi dokumenter, metode observasi, dan metode angket. Analisis data dilakukan melalui empat tahap, yaitu (1) pengumpulan data, (2) reduksi data, (3) penyajian data, dan (4) penarikan simpulan. Hasil penelitian ini menunjukkan tingkat keterpahaman dosen, mahasiswa, dan pegawai di Fakultas Bahasa dan Seni terhadap visi fakultas tergolong sangat baik.  Dalam pembelajaran, konsep Tri Hita Karana  diimplementasikan oleh dosen dalam bagian perencanaan, pelaksanaan, maupun dalam kegiatan evaluasi pembelajaran. Konsep Tri Hita Karana diintegrasikan untuk melandasi setiap komponen strategi pembelajaran baik pada tahap perencanaan, pelaksanaan, maupun pada tahap evaluasi.
Implementation of Data Mining to Predict The Feasibility of Blood Donors Using C4.5 Algorithm
Authors: Febriani Anita , Rahmawati Tiara Trimadya , Sabna Eka
Published: October 2019

Blood Transfusion Unit PMI Pekanbaru City is part of a company or agency that serves blood donation, every blood bag obtained from the community voluntarily come to PMI to donate blood with the goal of humanity. In Blood Transfusion Unit PMI Pekanbaru City, has provisions to be blood donors that must be met in order to donate blood in UTD PMI Pekanbaru City. Data Mining is a combination of a number of computer science disciplines that are defined as the process of discovering new patterns from massive data sets. By using RapidMiner software and using the method of Decision Tree Algorithm C4.5 to determine the eligibility of blood donors based on Age, Weight, Hemoglobin, and Blood Pressure. In the study of hemoglobin is the most decisive variable in blood donors. And the result accuracy is 94.02% which means the accuracy of this model is very good.
Spam Classification on 2019 Indonesian President Election Youtube Comments Using Multinomial Naïve-Bayes
Authors: Fernando Jonathan Radot , Budiraharjo Raymond , Haganusa Emeraldi
Published: October 2019

Text classification are used in many aspect of technologies such as spam classification, news categorization, Auto-correct texting. One of the most popular algorithm for text classification nowadays is Multinomial Naïve-Bayes. This paper explained how Naïve-Bayes assumption method works to classify 2019 Indonesian Election Youtube comments. The output prediction of this algorithm is spam or not spam. Spam messages are defined as racist comments, advertising comments, and unsolicited comments. The algorithms text representation method used bag-of-words method. Bag-of-words method defined a text as the multiset of its words. The algorithm then calculate the probability of a word given the class of spam or not spam. The main difference between normal Naïve-Bayes algorithm and Multinomial Naïve-Bayes is the way the algorithm treats the data itself. Multinomial Naïve-Bayes treats data as a frequency data hence it is suitable for text classification task.
Monitoring indikatora
kliničke zdravstvene njege kao pokazatelj kvalitete i sigurnosti zdravstvenih
usluga
Authors: Ovčina Amer , Štitkovac Hazim , Hrustemović Dženana , Čamdžić Azra , Konjo Hadžan , Eminović Ernela
Published: October 2019

Continuous progress in the nursing profession has a significant impact on the quality in the process of clinical care, which brings about new challenges and tasks for nurses to invest in new knowledge and skills. The healthcare process requires a systematic team approach in the design of evidence-based tasks, good clinical practice and clinical guidelines, documented standardized phenomena and evaluated measurements and tests. Measurement instruments and statistical tests of treatment effectiveness are used to assess the quality of health care provided. For a successful measurement and analysis of the quality of clinical care, it is necessary to have standardized healthcare documentation that allows treatment and outcomes monitoring. Qualitative and safety indicators are used to assess the quality of clinical health care, which represent a means of measurement, screening or warning. Monitoring Quality and Safety Indicators in Health Care Services is used as a guide to monitoring, evaluating and improving the quality of health care, and supporting services and organizational functions. In the field of health care, we measure the total treatment, outcome of the healthcare process, patient satisfaction, unwanted events,quality of life, etc.
Psoriasis
– the impact on an individual´s mental state and quality of life
Authors: Vévodová Šárka , Havelka Filip , Vévoda Jiří , Grygová Bronislava
Published: October 2019

Introduction: Psoriasis is a chronic skin disease
characterized by scaly patches affecting approximately 2-5% of the population.
The disease has a negative impact on quality of life and, therefore, psoriatic patients
often develop depression. Our work deals with quality of life and depression in psoriasis sufferrers and strives to
determine the correlation between their quality of life and depression.
Methods:
The research took place in the University Hospital Olomouc in 2017 and used
questionnaires WHOQOL-BREF and BDI-II. 50 patients with psoriasis were chosen
randomly. To process the data we used Mann-Whitney test (the level of
significance = 5%) and Spearman´s correlation coefficient (the level of
significance = 1%).
Results:
The results proved that psoriasis has a significant impact on quality of life.
The scores for the overall life quality as well as for individual domains were
significantly lower in psoriatic patients than in the control group (p<0.001).
The degree of depression in patients with psoriasis showed statistically
significant correlation in all domains of the quality of life. We proved
negative correlation in the overall quality of life (rs =- 0.691**), physical condition (rs
=-0.499**),
social relations (rs =-0.546**), overall health (rs
=-0.396**),
and environment (rs =-0.386**).
Conclusion:
With regard to the ascertained negative correlation between psoriasis and
depression and lower quality of life of the sufferers compared to the healthy population,
it is essential for healthcare professionals to pay attention not only to
somatic manifestations of the disease but also to the patients´ mental health.
Metode procjene tjelesne aktivnosti osoba starije
životne dobi
Authors: Crnković Ivana
Published: October 2019

U ovom radu sistematizirane
su i opisane metode procjene tjelesne aktivnosti koje se najčešće primjenjuju u
istraživanjima namijenjenima osobama starije životne dobi. Prije procjene razine
tjelesne aktivnosti kod osoba starije životne dobi važno je provesti
antropometrijska mjerenja te procjenu funkcionalnog statusa. Upitnici za
procjenu tjelesne aktivnosti učestalo se primjenjuju, i to najčešće radi
rasterećenja administracije, nižih troškova provedbe istraživanja, kao i
mogućnosti obrade kvantitativnih i kvalitativnih podataka, dok je glavni
nedostatak problem pouzdanosti i validacije. U novije vrijeme razvijeni su
različiti sustavi monitoringa domene tjelesne aktivnosti kod ove populacije.
Ova metoda monitoringa uključuje akcelerometre od kojih se najviše upotrebljava
Actigraph (GT1M) koji je dostupan široj populaciji. Nedavno je razvijena i nova
metoda praćenja, SenseWear Pro 3 trake za ruku (SP3), koja ne samo da
inkorporira akcelerometriju u proračune potrošnje energije nego bilježi i fluks
topline, galvanski otpor kože, temperaturu kože i približnu temperaturu tijela
putem niza senzora koji su locirani na uređaju. DLW, tehnika uporabe vode
obilježene stabilnim izotopima vodika i kisika naziva se „zlatnom normom” kao
najpreciznija metoda za procjenu prosječnog utroška energije tijekom određenog
perioda.
Female sexual function as a predictor of
well-being
Authors: Starc Andrej , Perat Mitja , Levec Tina , Dahmane Raja , Poljšak Borut
Published: October 2019

Introduction: The purpose of this study was to
evaluate the relationship between the
WHO-5 Well-Being Index and variables from the Female Sexual Function Index
(FSFI) in a large-scale
sample of partnered and single
women. Methods: Based on the Kolmogorov-Smirnov
and Shapiro-Wilk test on six claims of FSFI, a non-parametric statistical
analysis was used. Results: Statistical significance was set at p<0.05. The sample included 635
female participants, aged 18 to 89 years. There was a strong link between all
the six FSFI claims with marital status and number of sexual partners. The
group of women who were involved in sexual intercourse in the previous 4
weeks shows higher life satisfaction (n=366; 50-100%) compared to the group
(n=37; 0-49%) who were not involved in sexual intercourse in the previous 4 weeks. Even though the frequency of sexual
functioning according to FSFI scores did not differ between the two groups (χ2
(1)=0.101, p=0.750), they did differ in the quality of sexual experience. Conclusions: These results
extend previous findings by confirming a strong relationship between sexual
well-being and overall life satisfaction within individuals. They confirm the importance of sexual satisfaction in shaping the overall quality of life not only for men but also for women.
Utjecaj bolesti na povijest – primjer epidemija
Authors: Barišić Jelena
Published: October 2019

Povijest bolesti može se
istraživati na različite načine. Istraživanje može ostati u striktno
medicinskim okvirima i fokusirati se na oblik bolesti, pitanja prevencije,
metode liječenja i drugo. Međutim, bolest nije samo medicinski fenomen zato što
se njezine posljedice osjećaju na široj društvenoj razini. Stoga je važno
uočiti na koji način bolest utječe na povijest.
U radu se ovaj
utjecaj promatra na primjeru triju epidemija koje su u različitim povijesnim
periodima poharale različita područja. Spomenuti utjecaj promatra se kroz
prizmu trajanja, geografskog dosega te pretpostavke bi li povijest bila
drugačija da se bolest nije dogodila.
Evaluation of concurrent analysis of cerebrospinal fluid samples collected from the cerebellomedullary cistern and lumbar subarachnoid space for the diagnosis of steroid-responsive meningitis arteritis in dogs
Authors: Carletti Beatrice E. , De Decker Steven , Rose Jeremy , Sanchez-Masian Daniel , Bersan Erika , Cooper Camilla , Szladovits Balazs , Walmsley Gemma , Gonçalves Rita
Published: October 2019

OBJECTIVE

To evaluate whether concurrent analysis of CSF samples from 2 collection sites (cerebellomedullary cistern [CMC] and lumbar subarachnoid space [LSS]) versus only 1 site could improve the diagnostic sensitivity of CSF analysis for dogs with suspected steroid-responsive meningitis arteritis (SRMA).

ANIMALS

111 client-owned dogs with SRMA diagnosed at 3 veterinary referral hospitals between 2011 and 2017.

PROCEDURES

Only dogs with CSF collected from both sites (CMC and LSS) and with no previous history of corticosteroid administration were included. Medical record data and logistic regression were used to identify factors associated with having a total nucleated cell concentration (TNCC) within the reference interval in a CSF sample from 1 collection site.

RESULTS

The TNCC was within the reference interval (TNCC < 5 cells/μL) in the CSF sample from 1 collection site for 8 of 111 (7%) dogs and was only slightly high (TNCC, 5 to 9 cells/μL) in the sample from 1 or both sites for 10 (11%) other dogs. For each of these 18 dogs, results for samples from 1 site were consistent with SRMA. The proportion of CSF samples that had a TNCC within the reference interval was comparable between sites. As age increased, so did the risk of having an unremarkable TNCC in the CSF sample from 1 site, albeit only slightly (OR, 1.08; 95% confidence interval, 1.01 to 1.16).

CONCLUSIONS AND CLINICAL RELEVANCE

CSF samples from both the CMC and LSS should be analyzed when evaluating dogs with suspected SRMA to improve the chance of detecting a high TNCC.
Clinical characteristics, classification, and surgical outcome for kittens with phimosis: 8 cases (2009–2017)
Authors: de Vlaming Annemarieke , Wallace Mandy L. , Ellison Gary W.
Published: October 2019

OBJECTIVE

To describe clinical characteristics and surgical outcomes for kittens with phimosis and to develop a system to classify phimosis on the basis of gross pathological lesions.

ANIMALS

8 kittens with phimosis.

PROCEDURES

Medical record databases of 2 veterinary teaching hospitals were searched to identify records of cats ≤ 20 weeks old (ie, kittens) with phimosis that underwent surgical intervention between 2009 and 2017. For each kitten, information extracted from the record included signalment, history, clinical signs, physical examination findings, treatments, and details regarding the surgical procedure performed, postoperative complications, and outcome.

RESULTS

The most common clinical signs were stranguria (n = 6), marked preputial swelling (5), and a small (6) or inevident (2) preputial orifice. Six kittens had type 1 phimosis (generalized preputial swelling owing to urine pooling without penile-preputial adhesions) and underwent circumferential preputioplasty. Two kittens had type 2 phimosis (focal preputial swelling and urine pooling in the presence of penile-preputial adhesions) and underwent preputial urethrostomy. No postoperative complications were recorded for kittens that underwent preputial urethrostomy. All 6 kittens that underwent circumferential preputioplasty had some exposure of the tip of the penis immediately after surgery, which typically resolved over time. At the time of last follow-up (mean, 1.4 years after surgery), all 8 patients were able to urinate and had no signs of phimosis recurrence.

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggested that circumferential preputioplasty and preputial urethrostomy could be used to successfully manage kittens with type 1 and type 2 phimosis, respectively.
Management of nephrolithiasis by pyelotomy and pyeloscopy in an Asian small-clawed otter (Aonyx cinereus)
Authors: Sabater González Mikel , Osterwind Melanie , Fernández Colomé Jaime
Published: October 2019

CASE DESCRIPTION

A captive adult sexually intact female Asian small-clawed otter (Aonyx cinereus) was evaluated because of diarrhea and signs of abdominal discomfort on arrival at the quarantine area of a zoological park.

CLINICAL FINDINGS

Radiographic and ultrasonographic examinations revealed the presence of a large nephrolith in the left kidney. Mild nephrolithiasis was detected in the right kidney. Results of hematologic and serum biochemical analyses were within references intervals. Intravenous pyelography was used for functional assessment of the urinary system and revealed normal renal excretory function bilaterally.

TREATMENT AND OUTCOME

Unilateral (left-sided) pyelotomy was selected as a treatment option to preserve maximal functional renal tissue. Pyeloscopy was successfully used for detection of some small nephroliths that were not removed by repeated flushing of the renal pelvis. Surgical treatment of the right kidney was not considered necessary. The otter recovered fully from anesthesia and surgery. Renal function was considered normal when assessed at 3 and 7 days and at 1 and 12 months after surgery.

CLINICAL RELEVANCE

To the authors' knowledge, pyelonephrotomy in otters has not been reported and may be considered as a potential surgical solution for nephrolithiasis. Pyeloscopy allowed the identification of small uroliths that were not removed by repeated flushing of the left renal pelvis following removal of the large nephroliths.
Minimally Invasive Radiofrequency Ablation for Large Thyroid Toxic Adenoma
Authors: Belitova M. , Ivanov S. , Marinov Ts. , Popov T. , Pandev R.
Published: October 2019

Background: Most thyroid nodules are benign and do not need intervention. Toxic adenoma and toxic multinodular goiter (MNG) are common causes of hyperthyroidism, second in prevalence only to Graves’ disease. Toxic adenoma and MNG are the result of focal or diffuse hyperplasia of thyroid follicular cells whose functional capacity is independent from regulation by the thyroid stimulating hormone (TSH). When conservative treatment modalities fail to ensure an euthyroid state, surgical intervention is required, typically surgical left or right thyroid lobectomy. Radiofrequency ablation (RFA) is a new percutaneous treatment option that results in thermal tissue necrosis and fibrosis. As a result of this process, the thyroid nodules shrink.

Case presentation: We describe a case of a young woman with a large toxic thyroid adenoma who refused surgery. She was admitted to a one-day surgery unit and underwent radiofrequency ablation under total intravenous anesthesia. Using “moving shot technique” the procedure went uneventfully and the toxic adenoma displayed a significant volume reduction with resolution of the hyperthyroid symptoms. The patient also reported a significant improvement of her neck symptoms (from 7/10 to 1/10 on a Visual Analogue Scale).

Conclusions: Radiofrequency ablation is a new, well tolerated, safe and effective treatment option in selected patients with benign thyroid nodules, toxic adenomas of the thyroid gland and multinodular goiter. To the best of our knowledge, this is the first time such treatment modality is used in Bulgaria.
Calculation Approaches of the Probable Maximum Discharge of Spring Flood at Ungauged Sites in the Southern Buh River Basin, Ukraine
Authors: Gorbachova Liudmyla , Khrystyuk Borys
Published: October 2019

Calculation of probable maximum discharge of spring flood are the great practical importance, since it is the basis to plan and design of different hydraulic structures, such as dams, culverts, urban and agriculture drainage systems, etc. Thus, the updating of the methodical approaches and parameters of the empirical formulas which using in the determining of the probable maximum discharge of spring flood at ungauged sites of the river basin is an actual task. In this paper for the Southern Buh River Basin were updated the parameters of the reduction formula and the limiting intensity formula of streamflow which are using to calculated of the probable maximum discharge of spring flood at ungauged basin in Ukraine. The presented results illustrate that parameters of empirical formulas that were calculated according to modern observation series (since the beginning of the observations to 2010) in comparison with previously received (since the beginning of the observations to 1980) have significant changes. We found out that it is due to cyclical of the long-term fluctuations of the maximum streamflow of spring flood in the Southern Buh River Basin. We also illustrated that for the small ungauged basins have the difficulties with the choice of rivers-analogues.
The Flooding Risk in the City of Relizane (Algeria)
Authors: Baki Touhami , Rezini Djelloul
Published: October 2019

The town of Relizane was built near Oued Mina, upstream of which is erected a dam of Sidi M'hamed Benaouda; while the city was protected in its time by a dike dating from the colonial period. Local authorities have recovered the land near the floodplain by building a new dike replacing the old one. However, flood risks persist on the city. Flood risk management plans for this new area should be provided for better protection of citizens and property.
Disabled Population in India: A Regional Analysis
Authors: Ariz Dilshad
Published: October 2019

Disability is a medical term in India and the person with impairment is considered to be disabled. India is still following the medical model of disability which is the oldest model of disability and highly criticized for providing a narrow definition for disability. Based on this model, Census of India 2011 has given eight categories of disabled population. This study is based on secondary sources of data from Census of India 2011 and Ministry of Social Justice and Empowerment. The principal objective of this paper is to understand and analyze the regional variation of disabled population of India and the location of national institutions for the disabled. Research reveals that the highest disability concentration is found in the central zone and the eastern zone of India. Moreover, types of disabled population also show a spatial pattern like seeing disabled population are concentrated in the eastern zone of India and speech disabled population are concentrated in the western zone of India. Further the result of study reveals that the number of institutes for the disabled are insufficient and the location does not align with the spatial pattern of types of disabled. The researcher suggests that there is a need for more national institutions to set up and location of the institutions must align with the spatial pattern of the types of disability.
Determination of non-cholesterol sterols in serum and HDL fraction by LC/MS-ms: Significance of matrix-related interferences
Authors: Vladimirov Sandra , Gojkovic Tamara , Zeljkovic Aleksandra , Jelic-Ivanovic Zorana , Spasojevic-Kalimanovska Vesna
Published: October 2019

Background

Non-cholesterol sterols (NCS) are promising biomarkers for estimation of cholesterol homeostasis properties. In addition, determination of NCS in high-density lipoprotein (HDL) fraction (HDL-NCS) could provide information on cholesterol efflux. However, matrix effects interfere in liquid chromatography–mass spectrometry (LC-MS) analysis of NCS, thereby impairing the method sensitivity. The aims of this study were development, optimization and validation of LC-MS method for quantification of NCS in serum and HDL-NCS. Additionally, matrix effect interferences and methods application in individual serum samples were examined.

Methods

HDL precipitating reagent was used for HDL isolation. Matrix effect was examined by comparing different surrogates by simple regression analysis. Validation was conducted according to the FDA-ICH guideline. 20 healthy volunteers were recruited for testing of method application.

Results

The observed matrix effect was 30%, and matrix comparison showed that cholesterol was the dominant contributor to the matrix effect. Cholesterol concentration was adjusted by construction of the calibration curve for serum and HDL fraction (5 mmol/L and 2.5 mmol/L, respectively). The intra- and inter- run variabilities for NCSs were 4.7–10.3% for serum NCS and 3.6–13.6% for HDL-NCS and 4.6–9.5% for serum NCSs and 2.5–9.8% for HDL-NCS, respectively. Recovery studies showed satisfactory results for NCSs: 89.8–113.1% for serum NCS and 85.3–95.8% for HDL-NCS.

Conclusions

The method was successfully developed and optimized. The matrix interference was solved by customising calibration curves for each method and sample type. The measurement of NCS in HDL fraction was proposed for the first time as potentially useful procedure in biomedical researches.
Takotsubo Cardiomyopathy Precipitated By Thyroidectomy - A Case Report
Authors: Vujovic Katarina Savic , Stefanovic Branislav S. , Matic Dragan , Komnenovic Snezana , Toskovic Anka , Divac Nevena , Vuckovic Sonja , Prostran Milica
Published: October 2019

Takotsubo cardiomyopathy (TC) is an acute cardiac condition triggered by emotional or physical stress. General anesthesia and sympathetic activation are possible triggers for TC. However, little is known about the role of sympathovagal activity in TC. In our report, we present a female patient, aged 62, who underwent thyroidectomy and at the end of the surgery developed cardiac complications. The patient had no chest pain, but had ST depression and negative T waves on the electrocardiogram (ECG). Cardiospecific enzyme troponin was elevated. Cardiac catheterization revealed unobstructed coronary arteries. Echo-cardiography revealed the enlargement of the left ventricle and ejection fraction of 40%. The patient was diagnosed with TC and dual antiplatelet therapy was introduced, a beta blocker and ACE inhibitor.It is possible that TC in perioperative period after thyroidectomy in this patient occured due to both sympathetic and parasympathetic activation. Probably, extraction of large thyroid induced vagal stimulation which resulted in hypotension and bradicardia. The patient was subsequently treated with adrenaline and atropine. In this case, sympathetic and parasympathetic activation in different intervals could result in the development of this condition.
The EU: Towards a United States of Europe
Authors: Servais Eric
Published: October 2019

The European Union (EU), a contested “European” political construct, is contemporarily positioned at a critical juncture that presents three options that may determine its status as a supranational actor: stagnation, dissolution, or deeper and wider integration. The myriad pressures antagonizing the European Union and its structural foundations parallel those that the project sought to address following World War II. The unprecedented level of devastation caused by advanced military technologies and totalitarian ideologies in the war provided the impetus for increased cooperation amongst independent nation-states. Institutional cooperation encourages the deconstruction of destructive socio-political forces including racism, nationalism, and primordial cultural identities. These essentialist forces emerge in the absence of effective governance and encourage internal and external hostilities. The EU is intended to provide a structural framework for liberal-democratic countries to make collective decisions to increase economic prosperity, freedom, security, and justice [...]
Power Sharing: The Separation of Power in a Political System
Authors: Sanfacon Melissa
Published: October 2019

Corruption and the abuse of power within a political system would be inevitable without regulation. Political writers and philosophers have theorized about how to control the abuse of power for centuries. A solution, though evolving over time, was introduced through the concept of sharing power amongst multiple government entities and across different levels of government. This essay will discuss the sharing of power in regards to the following: theoretical origins of thought, methods of sharing power including the separation of power and federalism, and how these concepts operate. These elements will be discussed in order to assert the importance of sharing power within a political system. The Canadian system of government will be used as an example to display how the abuse of power is shared within a political system [...]
Number of cosmetic procedures among women in Saudi community
Authors: Almasri Rola , Alomawi Maimouna , Alotaibi Malak , Ghamdi Shahad , Alahmadi Marwa , Alhabshan Hattan , Alosaimi Mariam
Published: October 2019

Background: In recent years, an increase in the number of cosmetic procedures was seen, either surgical or non-surgical, especially in middle age women. This study aims to estimate the prevalence of cosmetic procedures among Saudi women in Riyadh city and to determine the factors that can affect the performance of these procedures.
Methodology: This cross-sectional study of a convenient sample encompassed 500 women at universities and malls, in Riyadh, Saudi Arabia. The study was conducted between December 2016 and February 2017. A self-administrated questionnaire was distributed to all participants, which covered eight domains, including socio-demographic data, and surrounded social influence.
Results: In total, 500 women responded to the questionnaire, and 55.4% of them had done a cosmetic procedure. Among the participants, 54.7% of participants who had no cosmetic surgery, was because they did not need it, while 17% of them said no because of financial reasons, and 9.4% because of social causes. Among those who underwent cosmetic surgery, 58.1% of participants responded that their purpose was for change and having more beautiful hands. However, 31% of them undergone cosmetic surgeries to treat the changes that had been happened to their faces and body.
Conclusion: There was acceptance of cosmetic procedures, especially in single women. Self-satisfaction was the most critical factor that affected the performance of cosmetic procedures, while the social reason was the least. Further studies should be done with a larger sample and in other cities.
HUBUNGAN KEGUGURAN DAN ANEMIA DENGAN PERNIKAHAN USIA MUDA DI DESA HAPESONG LAMA
Authors: Suryaningsih Melfi , Asfriyati Asfriyati , Santosa Heru
Published: October 2019

Pernikahan usia muda akan berlanjut dengan kehamilan usia muda. Akibat belum siapnya sistem reproduksi remaja untuk menerima kehamilan meningkatkan risiko untuk terjadinya komplikasi yang berpotensi meningkatkan angka kematian ibu dan bayi. Remaja dalam proses pertumbuhan dan perkembangan harus berbagi nutrisi dengan janin yang dikandungnya. Anemia kehamilan merupakan salah satu risiko yang akan dihadapi ibu hamil muda jika kebutuhan tubuh dan janinnya tidak tercukupi, selain itu keadaan psikologi remaja yang masih belum stabil dan siap dengan perubahan peran baru akan memicu terjadinya keguguran akibat stres. Tujuan penelitian adalah untuk memperoleh informasi hubungan pernikahan usia muda dengan keguguran dan anemia. Metode yang digunakan adalah Desain potong lintang, sampel 78 orang yang diambil secara simple random sampling. Pengambilan data dengan wawancara menggunakan kuesioner. Variabel terikat adalah pernikahan usia muda, variabel bebas adalah keguguran dan anemia. Analisis data dengan uji Chi Square. Hasil penelitian yaitu tidak terdapat hubungan menikah usia muda dengan keguguran tetapi terdapat hubungan yang bermakna antara pernikahan usia muda dengan anemia (p<0,05). Dapat disimpulkan bahwa ibu yang menikah muda berisiko mengalami anemia kehamilan dibandingkan dengan ibu yang menikah pada usia reproduksi sehat. Young marriages will continue with young pregnancies. As a result of not being ready for the adolescent reproductive system to accept pregnancy increases the risk for complications that could potentially increase maternal and infant mortality. Adolescents in the process of growth and development must share nutrients with the fetus they contain. Anemia of pregnancy is one of the risks faced by young pregnant women if the body and fetal needs are not fulfilled, besides the psychological state of adolescents who are still unstable and ready for a new role change will trigger a miscarriage due to stress. The purpose of this study was to obtain information on the relationship of young marriage with miscarriage and anemia. The method used is a cross-sectional design, a sample of 78 people taken by simple random sampling. Retrieval of data by interview using a questionnaire. The dependent variable is young marriage, the independent variable is miscarriage and anemia. Data analysis with Chi Square test. The results of the study are that there is no relationship between young marriage and miscarriage but there is a significant relationship between young marriage and anemia (p <0.05). It can be concluded that mothers who marry young are at risk of developing pregnancy anemia compared to mothers who marry at a healthy reproductive age.
KEAKTIFAN SISWA DARI ASPEK SIKAP DAN KETERAMPILAN MELALUI PEMBELAJARAN AKTIF
Authors: Halifah Iip Siti , Fajarianingtyas Dyah Ayu , Meita Nisfil Maghfiroh
Published: October 2019

Pembelajaran aktif adalah pembelajaran yang dapat mengaktifkan siswa dalam mencari jawaban atas pertanyaan yang di berikan guru dan juga aktif dalam mencari solusi untuk masalah yang diberikan guru. Dalam pembelajaran aktif untuk mendapatkan keaktifansiswadariaspeksikap dan keterampilan terjadi melalui proses pencarian atau percobaan. Keaktifan siswa di MTs Aqidah Usymuni dari aspek sikap, dan aspek keterampilan rendah. Salah satu solusi yang dapat diterapkan yaitu pembelajaran akif. Penelitian ini bertujuan untuk mengetahui keaktifan siswa dari aspek sikap, dan aspek keterampilan setelah diterapkan pembelajaran aktif. Jenis penelitian ini merupakan Penelitian Tindakan Kelas (PTK). Subjek penelitian adalah siswa kelas VIII  yang terdiri 16 siswaperempuan.Teknik pengumpulan data berupa lembar observasi. Data keaktifan siswa dari aspek sikap, aspek keterampilan dianalisis secara deskriptif dengan persentase. Hasil penelitian yang didapatkan yaitu (1) dan pada aspek sikap indikator bertanya termasuk kategori sangat tinggi, dan indikator berpendapat termasuk kategori tinggi; (2) serta pada aspek keterampilan indikator melakukan percobaan termasuk kategori sangat tinggi,  indikator menjelaskan hasil percobaan termasuk kategori sangat tinggi,  dan indikator merefleksi  termasuk ketegori sangat tinggi. Pembelajaran Aktif dapat mengetahui keaktifan siswa dari aspek sikap, dan keterampilan.
HUBUNGAN PENGETAHUAN LINGKUNGAN HIDUP DENGAN KESADARAN LINGKUNGAN PADA SISWA SEKOLAH ADIWIYATA
Authors: Munawar Syella , Heryanti Erna , Miarsyah Mieke
Published: October 2019

Jakarta merupakan wilayah perkotaan di Indonesia yang memiliki banyak permasalahan lingkungan. Kesadaran lingkungan diperlukan dalam upaya untuk menyelesaikan permasalahan lingkungan. Kesadaran lingkungan dalam diri siswa dapat dibentuk oleh tingkat pengetahuan lingkungan. Program sekolah berbasis lingkungan dilaksanakan melalui program Adiwiyata. Tujuan program Adiwiyata untuk mendorong dan menciptakan sekolah yang peduli tentang lingkungan dan memiliki budaya lingkungan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan lingkungan hidup dengan kesadaran lingkungan pada siswa sekolah Adiwiyata. Penelitian ini dilaksanakan di SMAN 26 dan SMAN 65 Jakarta pada Semester I Tahun Ajaran 2018/2019. Metode yang digunakan yaitu metode deskriptif kuantitatif melalui studi korelasional. Sampel yang digunakan sebanyak 124 siswa menggunakan teknik Simple Random Sampling. Alat pengumpulan data menggunakan tes pengetahuan lingkungan hidup dan instrumen kesadaran lingkungan. Analisis uji prasyarat menunjukkan data berdistribusi normal menggunakan uji Kolmogorov-Smirnov dan homogen menggunakan uji Bartlett. Hasil penelitian menunjukkan bahwa terdapat hubungan positif dan signifikan antara pengetahuan lingkungan hidup dengan kesadaran lingkungan siswa dengan koefisien korelasi sebesar 0,298. Hal tersebut berarti jika skor pengetahuan lingkungan hidup tinggi, maka skor kesadaran lingkungan juga tinggi. Pengetahuan lingkungan hidup memberikan kontribusi terhadap kesadaran lingkungan siswa sebesar 8,89%.
Akılcı İlaç Kullanımının Boylamsal Bir Koridor Şeklinde Üç Yıllık Klinik Eğitim Programına Entegrasyonu
Authors: TERZİOĞLU BEBİTOĞLU Berna , GÜLPINAR Mehmet Ali
Published: October 2019

Akılcı ilaç kullanımı ile ilgili ülkemizde ve dünyada çok sayıda eğitim faaliyeti yürütülmektedir. Ancak yapılan çalışmalarda günümüzde halen akılcı olmayan ilaç kullanımı olduğu, hekimlerin ve özellikle yeni mezun hekimlerin bu konuda yeterliğe sahip olmadığı ve öğrencilerin kendilerini reçete yazma konusunda yeterli hissetmediklerini bildirilmektedir. Bu nedenle mezuniyet öncesi eğitim döneminde başlayan ve ileri eğitim ve meslek yaşamları boyunca devam eden eğitimlerle akılcı ilaç kullanımının devamlılığının sürdürülmesi önemlidir.   Öğrenen merkezli eğitim modellerinde öğrenenlerin kendi öğrenme süreçlerini yönettiği probleme dayalı öğrenme ve işbaşında öğrenme gibi aktif öğrenme yöntemleriyle rasyonel farmakoterapi eğitiminin yürütülmesi, öğrenmede kalıcılığın artırılması ve doktorların ilerideki klinik pratiklerinde kendi başlarına kaldıklarında rasyonel ilaç kullanımını değişen koşullara göre uygulayabilme yeterliğini kazanmaları için gereklidir. Klinik tedavi kılavuzları ve temel ilaç listeleri ile uyumlu rasyonel farmakoterapi eğitimi iyi reçeteleme alışkanlığı kazandırmak için yararlı olmaktadır. Öğrencilerin bilgi, beceri ve tutumları dikkate alarak, sıklıkla karşılaşılan klinik durumlar üzerinden yapılan probleme dayalı öğrenme ile işbaşında öğrenme etkinlikleri rasyonel ilaç kullanımı kazandırılması noktasında tercih edilebilecek etkili yöntemlerin başında gelmektedir. Yine, toplumda sık görülen hastalıklara yönelik rasyonel farmakoterapi eğitim modülleri ile, akılcı ilaç kullanımının tıp fakültelerinde klinik eğitim dönemlerinde tüm staj programlarına boylamsal bir koridor olarak entegre bir şekilde dahil edilmesi ile, öğrencilerin karşılaşacakları hastalıklarda reçete yazmada kendilerine güven duymalarına, kişisel ilaç formülerlerini hazırlayabilmelerine ve güvenli ve etkili tedavi planları oluşturabilmelerine olanak sağlayacaktır.