bluuebunny/crossref_metadata_2025 huggingface dataset:
Resistive Switching and Hysteresis Phenomena at Nanoscale
Authors: Raja Vithaldas , Mohan Thamankar Ramesh
Published: October 2022

Resistive switching at the nanoscale is at the heart of the memristor devices technology. These switching devices have emerged as alternative candidates for the existing memory and data storage technologies. Memristors are also considered to be the fourth pillar of classical electronics; extensive research has been carried out for over three decades to understand the physical processes in these devices. Due to their robust characteristics, resistive switching memory devices have been proposed for neuromorphic computation, in-memory computation, and on-chip data storage. In this chapter, the effects of various external stimuli on the characteristics of resistive switching devices are comprehensively reviewed. The emphasis will be given on 2-dimensional (2D) materials, which are exciting systems owing to superior electrical characteristics combined with their high stability at room temperature. These atomically thin 2D materials possess unique electrical, optical and mechanical properties in a broad spectrum, and open the opportunity for developing novel and more efficient electronic devices. Additionally, resistive switching due to light has also grabbed the attention of optoelectronic engineers and scientists for the advancement of optical switches and photo tuned memristors. The variety of material systems used in the fabrication of memristors is comprehensively discussed.
Corruption Dynamics and Economic Growth in Nigeria
Authors: Ekundayo Rotimi Mathew , Aishat Umar Princess , Doorasamy Mishelle
Published: October 2022

Corruption is as old as man’s existence. It manifests in various places, ways, extent and sphere to impede economic growth, including Nigeria. This chapter presents corruption dynamics and its impact on economic growth in Nigeria. Among other things, the chapter reviewed the Nigerian economy in context, with focus on cases and forms (embezzlement, favoritism, bribery, and extortion) of corruption in Nigeria. Other matters discussed are anti-corruption agencies and channels of corruption in Nigeria. Following the review and discussions therein, the chapter concludes that corruption occurs in diverse forms and it is an act that deviates from the extant law. The study further concludes that the persistence of corruption in an economy impedes economic growth. The Nigerian case has proven that the grease-the-wheel assumption cannot hold because the growth of Nigeria has been affected drastically through the existence of corruption. Considering the dimensions that corruption has taken in Nigeria, it has become difficult or even impossible to eradicate corruption in the country, but curbing this cancer worm and reducing it to the barest minimum are of great importance to achieve the level of growth needed and make Nigeria restore sustainable economic growth path.
Non-Small Cell Lung Cancer Brain Metastasis: The Link between Molecular Mechanisms and Novel Therapeutic Approaches
Authors: Najjary Shiva , A.M. Mustafa Dana , M. Kros Johan
Published: October 2022

The prognosis of patients suffering from non-small cell lung carcinomas (NSCLC) worsens significantly when brain metastasis occurs. Seeding to the brain usually happens relatively early in the course of disease and therefore, new therapies anticipating this complication would result in considerable improvement in outcomes. In this review, we address recent molecular data of NSCLC with a focus on the risk of the formation of brain metastasis. Included is new data on the involvement of miRNAs and lncRNAs in the rise of the cerebral seeding of NSCLC. We summarize novel therapeutic approaches developed in the light of these recent molecular discoveries.
Perspective Chapter: A Renewed Perspective on Lean Six Sigma in Healthcare – People and Performance
Authors: J. de Koeijer Relinde , Paauwe Jaap , M.H. Strating Mathilde , Huijsman Robbert
Published: October 2022

The Lean Six Sigma (LSS) approach has taken a central role in healthcare quality management, and many studies report positive effects of the method on performance of healthcare organizations. However, LSS in healthcare is also unbalanced because the human side of the method is undervalued. A more balanced application of LSS in healthcare includes an interrelated approach of both “soft” and “hard” LSS practices, broad perspective on employee well-being, “soft” HR approach related to LSS, and “soft” climate for LSS. This leads to a renewed perspective on LSS in healthcare that considers both people and performance and where the interplay between “hard” and “soft” factors is addressed.
Production of Hydrogen via Water Splitting Using Photocatalytic and Photoelectrocatalytic Route
Authors: Sudhir Kumar Sinha Akhoury , Ojha Umaprasana , Alam Zahoor , Awdheshprasad Tripathi Ajay
Published: October 2022

Hydrogen has been intensively explored recently as an energy carrier to meet the growing demand for green energy across the globe. One of the most difficult and significant subjects in hydrogen energy technology is efficiently creating hydrogen from water by utilizing renewable resources such as solar light. Solar-based hydrogen production comprises several routes, namely, photocatalytic, photoelectrocatalytic, and photobiological decomposition. An efficient photocatalyst is desired to accomplish the above objective by utilizing the first two routes with a minimal rate of recombination of photo-generated charge carriers. In this chapter, strategies for preventing recombination of charge carriers in photocatalysts and the development of photocatalysts have been focused on, and its utilization in the procedure for the production of hydrogen via photocatalytic and photoelectrocatalytic processes is described.
Perspective Chapter: Antifungal Drug Resistance in Candida Species
Authors: Turan Deniz
Published: October 2022

Candida species, members of the normal body flora, are opportunistic mycosis agents that can cause infections associated with high morbidity and mortality rates in the presence of underlying predisposing factors. In recent studies, it has been reported that the incidence of invasive Candida infections caused by Candida species, such as non-albicans Candidaparapsilosis, Candida tropicalis, Candida glabrata, and Candida auris, in which antifungal drug resistance is more common, has increased, in addition to Candidaalbicans, the most frequently detected Candida species. In this context, the objective of this review article is to discuss the molecular mechanisms and biofilm-related factors responsible for the antifungal drug resistance developed in Candida species.
Pharmacological Properties of Ginger Combinations
Authors: Ongeri Ochora Douglas
Published: October 2022

Ginger (Zingiber officinale) is a widely cultivated plant due to its pharmacological properties and its use as a spice. The plant species enjoys a good reputation in most regions of the world mainly because of its anti-inflammatory, antitumor, and antioxidant activities. To enhance these pharmacological properties, ginger is mostly used in combination. Drug combination therapy is also a worthwhile strategy for the prevention of various diseases. Therefore, the current chapter concerted on pharmacological activities of ginger combinations. The plant species has been combined with other plant extracts, pure compounds, and approved drugs for antimicrobial, antioxidant, anticancer, antidiabetic, and antidepressant activities and also in herbal tea formulations. Most of these activities showed synergism with 50% inhibition concertation (IC50) values of less than 1. The highest activity was observed when ginger phytochemicals, shogaol, and gingerol derivatives were combined against prostate cancer cell lines with an IC50 value of 0.03. Interaction of different phytochemicals in ginger with other phytochemicals when used in combination account for the reported synergism. The observed synergism in most combinations depicts a potential use of ginger combinations in treatment and prevention of various diseases and disease conditions.
Baricitinib in the Treatment of COVID-19
Authors: Atal Shubham , Sampath Ananyan , Banerjee Aditya , Jhaj Ratinder
Published: October 2022

Baricitinib is a novel Janus kinase (JAK) inhibitor which has recently been included in recommendations for treatment of COVID-19. This chapter is focused on discussing the evidence available regarding the safety and efficacy of use of baricitinib alone or in combination with other therapies for treatment of patients with COVID-19. A systematic literature search was conducted for this purpose to find all clinical studies on baricitinib in treatment of COVID-19. A total of 30 studies, including both clinical trials and observational studies were identified, and they have been described briefly. Collation of the results from these observational and interventional studies shows that baricitinib either alone or in combination with other drugs, when used as an add-on to standard therapy, was found to have favorable outcomes in hospitalized patients with moderate to severe COVID-19. Furthermore, ongoing clinical trials indicate that the drug is still under evaluation across the world for its safety and efficacy in COVID-19. The recent approval of baricitinib by the US FDA for treatment of hospitalized adults with COVID-19 accurately reflects the role of the drug in COVID-19. Baricitinib improves clinical outcomes in hospitalized COVID-19 patients, and additional evidence may establish the drug as a standard treatment in such patients.
Agricultural Lands Preservation Plans and Laws in Iran: A Case Study
Authors: Armin Mohsen
Published: October 2022

In this chapter, laws and plans for the preservation of agricultural lands in Iran were expressed. For this purpose, electronic search of research background in the SID, Iran Doc and Sivilica was done. Results show that immediately after the Land Reform in Iran in 1971, Plans and laws including Agricultural Joint Stock Companies, Production Cooperatives Companies and so on have been implemented. The chapter argues that the approach of prevention and deterrence of land use change alone cannot be considered an effective solution for agricultural land management, and it is necessary to pay attention to the incentive and punitive aspects of careful land management and prepare a comprehensive land management document based on it. In addition to maintaining good quality agricultural land, the needs of other sectors such as industry and nature tourism to be properly addressed. Evidence show that in Iran, despite many laws and numerous plans, the process of changing the use of agricultural land has not been effectively controlled. Therefore, various suggestions such as setting up a land monitoring and evaluation system, granting facilities for the purchase of agricultural land to qualified people and so on are regularly presented by academic societies and executive experts.
Artificially Intelligent Super Computer Machines and Robotics: Apprehensions and Challenges – A Call for Responsible Innovation Framework
Authors: Rasheed Memon Khalid , Keat Ooi Say
Published: October 2022

“Industrial revolution 4.0” is a term that is becoming increasingly popular among academics. A number of articles have been carved to emphasize the beneficial aspects of the stated issue under many titles such as cyber-physical systems, internet of things, artificial intelligence, smart manufacturing, digitalization of industrial production, and so on. However, few academics have delved into the negative or dark side of such a profound technological paradigm change, especially the artificially intelligent robotics, creating a large knowledge vacuum. Because of this, little is known about the negative repercussions of artificial intelligence (AI), a key component of the Fourth Industrial Revolution (or IR 4.0). It is an open secret now that AI machines may have serious impacts on human autonomy, fairness, justice, and agency. These unanticipated consequences have resulted in the development of an emerging concept, that is, responsible innovation. The responsible innovation framework binds the firm ethically, morally, and socially to be responsible, environmentally friendly, humanitarian, and business-oriented while developing innovative products. The current study proposes an integrated responsible innovation framework that acts as a science governance mechanism and considers organizations and stakeholders collectively responsible for upcoming technological innovations. This study has suggested several implications for policymakers.
Application of Artificial Intelligence in Air Conditioning Systems
Authors: Myat Aung
Published: October 2022

Urbanization has led to a sharp rise in the demand for power over the past 10 years, alarmingly rising greenhouse gas (GHG) emissions. HVAC (heating, ventilation, and air conditioning) systems account for nearly half of the energy used by buildings, and minimizing the energy use of the HVAC systems is essential. However, the common problems, such as hot spots and cold spots in office spaces, experienced in the building need to be addressed. Therefore, this chapter introduces the application of artificial intelligence proactive control to resolve typical office issues. A demonstration testbed was implemented on the Singapore Institute of Technology (SIT) campus. The experiments were conducted in baseline mode and smart mode. In the case study, two big zones were segregated into 43 micro-zones equipped with smart dampers at each diffuser, allowing a localized set point to improve thermal comfort and eliminate hot and cold spots. It has been observed that the proactive AI control reduces cooling provided to the office by 29 percent and AHU electricity usage by 50 percent, respectively, while keeping the area within thermal comfort range of 23 to 25°C and 50 to 63% relative humidity.
Occupational Stress among Health Care Workers
Authors: Joshi Krupal , Modi Bhautik , Singhal Sanjay , Gupta Sanjay
Published: October 2022

Occupational stress is a harmful response particularly physical and emotional, due to a mismatch between job requirements and the qualifications, resources, and worker’s needs; its chronic form is termed “Burnout.” Stress among health care workers is multifactorial. Its prevalence among healthcare professionals ranges from 27−87.4%. Occupational stress is a significant reason for physical and mental health, substance use, work-related delay, absenteeism, and emigration rate. Additionally, it can lead to patient safety concerns and poor quality of care. The mismatch between job requirements and the available resources, work overload, working environment, work experience, workplace conflict, gender discrimination, marital status, educational status, job satisfaction, and not being rewarded were some of the factors significantly associated with occupational stress among health care professionals. Moreover, the coronavirus disease 2019 (COVID-19) pandemic introduced additional stressors, such as staff redeployment and the fear of infection. WHO identified good primary health care as fundamental for achieving universal health coverage without financial hardship. Healthcare professionals’ physical and mental well-being is crucial for attaining this. Developing culturally and organizationally appropriate early interventions is the need of the hour to prevent a health care worker from entering a stress level that is non-adaptable beyond their coping abilities.
Perspective Chapter: Defining and Applying the FMEA Process Method in the Field of Industrial Engineering
Authors: Pascu Cristina-Ileana , Malciu Raluca , Dumitru Ilie
Published: October 2022

The analysis of failure modes and effects (FMEA) is a method of analyzing the potential failure of a product or process and developing an action plan aimed at their prevention and increased quality of products, processes, and job production environments. As a method of critical analysis, FMEA has very clear objectives: determination of the weaknesses of a technical system; initiating causes of failure-seeking components; analysis of the environmental impacts, safety of operation, the product value; provision of corrective actions to remove the causes of the occurrence of defects; provision of a plan to improve product quality and maintenance; determining the needs of technology and modernization of production; increasing the level of communication between departments of working people at hierarchical levels. FMEA should be used before taking the product. Subsequently, there is no point, only because the customer demands it, to achieve FMEA. Therefore, FMEA must be within organizational conduct. This chapter describes the FMEA method and presents studies about the improvement of the quality process for some products from industrial engineering by using FMEA, such as: axis for packaging, assembly “stator Housing,” composite parts used in the railway field. The potential causes of the defects were studied, and improvement measures were proposed.
Marine Robotics 4.0: Present and Future of Real-Time Detection Techniques for Underwater Objects
Authors: Joo Er Meng , Chen Jie , Zhang Yani
Published: October 2022

Underwater marine robots (UMRs), such as autonomous underwater vehicles, are promising alternatives for mankind to perform exploration tasks in the sea. These vehicles have the capability of exploring the underwater environment with onboard instruments and sensors. They are extensively used in civilian applications, scientific studies, and military missions. In recent years, the flourishing growth of deep learning has fueled tremendous theoretical breakthroughs and practical applications of computer-vision-based underwater object detection techniques. With the integration of deep-learning-based underwater object detection capability on board, the perception of underwater marine robots is expected to be enhanced greatly. Underwater object detection will play a key role in Marine Robotics 4.0, i.e., Industry 4.0 for Marine Robots. In this chapter, one of the key research challenges, i.e., real-time detection of underwater objects, which has prevented many real-world applications of object detection techniques onboard UMRs, is reviewed. In this context, state-of-the-art techniques for real-time detection of underwater objects are critically analyzed. Futuristic trends in real-time detection techniques of underwater objects are also discussed.
Postoperative Analgesia
Authors: Eshetie Adane Denberu
Published: October 2022

A failure to maintain adequate pain control is a substandard and unethical practice. Pain has disastrous effects in which poorly controlled acute postoperative pain is associated with increased morbidity and mortality, impaired quality of life, delayed recovery time, prolonged opioid usage, and higher healthcare costs. Inadequate knowledge about analgesia and pain management leads the healthcare profession to ineffective postoperative pain management. The main goal of postoperative analgesia is to reduce or eliminate pain and discomfort with a minimum of side effects. Assessment of pain severity is vital before managing it. There are many analgesic options that can be used to manage acute and chronic postoperative pain. Recently, non-opioid analgesia methods are encouraged for acute postoperative pain control due to the side effect of opioids and the advancement of recent technologies for peripheral nerve block.
Sex Differences in Physical Attractiveness
Authors: Garza Ray
Published: October 2022

This chapter provides an overview of the literature on the sex differences in physical attractiveness, and how it influences mate choice. More specifically, it investigates evolutionary perspectives on men and women’s preferences for physical traits, such as ideal breast features in women, and masculine physical traits (i.e., muscularity, broad shoulders) in men. The chapter focuses on conditional (i.e., ecological/environmental) roles on mate preferences, in addition to examining possible individual differences, such as mate value. The chapter covers the following: (1) An overview of sex differences in attractiveness, including theoretical explanations, (2) A broad focus on women’s ideal preferences, (3) A broad focus on men’s ideal preferences, and (4) A discussion on conditional factors and individual differences influencing preferences for ideal traits.
The Perception of Intelligent Packaging Innovation: The Latest Process and Technological Progress
Authors: Loučanová Erika , Parobek Ján , Nosáľová Martina
Published: October 2022

As a result of global change and progress in recent decades, the approach to utilizing product packaging materials has changed. Subsequently, innovative packaging is the result of creative thinking beyond the usual thinking framework. A complete understanding of the customer’s needs is an indispensable requirement for the ability to develop packaging with optimized performance. The study deals with the perception of intelligent and active packaging by respondents in Slovakia. The approach of Kano model was applied for the study of customers’ attitudes to the individual functions of active and intelligent packaging. Firstly, the requirements of the packaging functions among the monitored age categories were identified. Subsequently, the innovation status within the individual age categories was evaluated. Thereafter, a 3D simulation was used to figure out the resultant perception of intelligent and active packaging functions in Slovakia. Based on the research results, we can conclude that the awareness of customers in Slovakia about intelligent packaging innovations is at a low level and is oriented towards a weak green strategy.
Alternatives for the Management of Industrial Forest Waste: Energy, Bioethanol, and Cellulose Pulp
Authors: Clavijo Leonardo , Guigou Mairan , Cassella Norberto , Cortizo Gastón , Risso Florencia , Velazco Lucía , Daniel Ferrari Mario , Lareo Claudia , Noel Cabrera María
Published: October 2022

Modern kraft pulp mills generate solid waste of 1–2% of incoming debarked wood. Given the size of these plants, with an annual production capacity of at least 1000,000 tons, each plant generates 20,000–30,000 dry tons of waste per year. The largest current use of these residues is for combustion in biomass boilers for steam and power generation. However, the conversion of biomass into biofuels and chemicals is gaining interest due to increasing demands for energy, limited sources of fossil fuels, and growing concerns about the environmental impact of greenhouse gas emissions. This chapter shows the laboratory-scale results of the use of eucalyptus wood wastes to obtain cellulose pulp by alkali pulping reinforced with hydrogen peroxide to obtain alkaline peroxide mechanical pulp or cellulosic bioethanol. Based on the results, an industrial-scale techno-economic analysis of the processes is presented and compared with current alternatives for energy generation.
Temporal Fluctuations Scaling Analysis: Power Law of Ramp Rate’s Variance for PV Power Output
Authors: André Maina , Calif Rudy
Published: October 2022

The characterization of irradiance variability needs tools to describe and quantify variability at different time scales in order to optimally integrate PV onto electrical grids. Recently in the literature, a metric called nominal variability defines the intradaily variability by the ramp rate’s variance. Here we will concentrate on the quantification of this parameter at different short time scales for tropical measurement sites which particularly exhibit high irradiance variability due to complex microclimatic context. By analogy with Taylor law performed on several complex processes, an analysis of temporal fluctuations scaling properties is proposed. The results showed that the process of intradaily variability obeys Taylor’s power law for every short time scales and several insolation conditions. The Taylor power law for simulated PV power output has been verified for very short time scale (30s sampled data) and short time scale (10 min sampled data). The exponent λ presents values between 0.5 and 0.8. Consequently, the results showed a consistency of Taylor power law for simulated PV power output. These results are a statistical perspective in solar energy area and introduce intradaily variability PV power output which are key properties of this characterization, enabling its high penetration.
Abiotic and Biotic Stress Factors Affecting Storage of Legumes in Tropics
Authors: Kide Mengistu Habtamu
Published: October 2022

Tropical regions such as South Asia (SA) and Sub-Saharan (SSA) do have storage environment that may impose abiotic and/or biotic stress or. This book chapter aims to broaden current knowledge on the ‘Abiotic and Biotic Stress Factors Affecting Storage of Legumes in Tropics’. This book chapter is prepared by including all relevant studies and detailed literatures using various scholastic search approaches. Typically, published papers and abstracts are identified by a computerized search of electronic data bases that include PubMed, Science Direct, Scirus, ISI Web of Knowledge, Google Scholar and CENTRAL (Cochrane Central Register of Controlled Trials). Thus, diseases, insects, etc…, are biological factors that cause biotic stress in plants while abiotic stress is caused by either physical or chemical factors. Biotic and abiotic stresses create adverse effects on multiple procedures of morphology, biochemistry and physiology that are directly connected with growth and yield of legume grains. It is, therefore, clear that the most important factors of food grains loss are moisture, temperature, metabolic activity and respiration, insects, mites, micro-organisms, rodents, birds and storage structures. Initial grain condition or quality of the seed for storage can indirectly be affected by abiotic stresses like water scarcity, high salinity, extreme temperatures, and mineral deficiencies or metal toxicities which reduce the crop’s productivity. For maintenance of storage of initial grain’s quality, grain must be dried and cooled prior to storage, the store must be constructed for blocking rodents and birds, enabling protection from sun and light entrance, allowing aeration to keep the temperature uniform in the store. Also, bringing the temperature of the grain down to below 12°C is necessary, since this temperature is a threshold at which microorganisms’ reproductive activity is inhibited. Storage spaces with higher relative humidity (95%) and a temperature of 35°C, are detrimental for storage of legume grains. In general, legume grains should be attaining a temperature of about ≤ 10 °C before placing them in store. For storage safety, it is preferable to place the grain in the storage at moisture content of 13%, or less than 14% on wet basis. Also, combining drying and storage facilities in one and the same structure is economical, and allows further conditioning at later stages if required. In order to reduce postharvest loss from customs of traditional storage by farmers in tropics, governments should mobilize and integrate multidisciplinary management system of storage loss, and monitor precautionary measures of the stored grain throughout the storage period. They should be facilitating the selection and promotion of alternative, cost-effective and appropriate storage structures considering suitability to local conditions and sustainability.
Epistemic Standards and Value: A Puzzle
Authors: Grindrod Jumbly ,   Romanian Academy - Iasi Branch
Published: October 2022

In this paper, I present a puzzle that arises if we accept i) that knowledge is more valuable than mere true belief and ii) that whether a person counts as knowing is dependent upon a context-sensitive epistemic standard. Roughly, the puzzle is that if both claims are true, then we should always seek to keep the epistemic standard as low as possible, contrary to what seems like appropriate epistemic behaviour. I consider and reject a number of different ways of avoiding this consequence before presenting my own solution to the puzzle: that any view that posits a context-sensitive epistemic standard must relativize epistemic value as well.
Gettier Unscathed for Now
Authors: Duff John C. ,   Romanian Academy - Iasi Branch
Published: October 2022

Moti Mizrahi (2016) argues that Gettier cases are unsuccessful counterexamples to the traditional analysis of knowledge (TAK) because such cases inadequately reveal epistemic failures of justified true belief (JTB); and because Gettier cases merely demonstrate semantic inadequacy, the apparent epistemic force of Gettier cases is misleading. Although Mizrahi claims to have deflated the epistemic force of Gettier cases, I will argue that the presence of semantic deficiency in Gettier cases neither requires nor indicates the denial of the epistemic force of those cases. I will provide an extracted version of Mizrahi’s argument, which I believe to be most charitable to his motivation. Then I will offer a counterexample to a pivotal premise in Mizrahi’s argument, ultimately rendering the argument unsound. Finally, upon the examination of a plausible objection, I conclude that Gettier cases are epistemically sustained.
Learning to Reframe Problems Through Moral Sensitivity and Critical Thinking in Environmental Ethics for Engineers
Authors: Gammon Andrea R. , Marin Lavinia ,   Philosophy Documentation Center
Published: October 2022

As attention to the pervasiveness and severity of environmental challenges grows, technical universities are responding to the need to include environmental topics in engineering curricula and to equip engineering students, without training in ethics, to understand and respond to the complex social and normative demands of these issues. But as compared to other areas of engineering ethics education, environmental ethics has received very little attention. This article aims to address this lack and raises the question: How should we teach environmental ethics to engineering students? We argue that one key aspect such teaching should address is the tendency of engineers towards technical framing of (social) problems. Drawing then on engineering ethics pedagogy we propose that the competencies of moral sensitivity and critical thinking can be developed to help engineering students with problem (re)framing. We conclude with an example from our teaching that operationalizes these competencies.
O desenvolvimento sustentável como cerne das proposições da UNESCO
Authors: Morosini Marília Costa
Published: October 2022

O trabalho discute proposições atuais da Organização das Nações Unidas para a Educação, a Ciência e a Cultura (UNESCO) para a educação superior, desvelando o conceito de desenvolvimento sustentável em diversos movimentos. A metodologia utilizada para a análise dos dados é o estado do conhecimento e tem como base documentos emblemáticos disponibilizados no site da UNESCO. Três movimentos foram identificados: 1) Agenda E2030 (2015) – transposição do conceito de desenvolvimento sustentável (ONU) para a educação; 2) Os Futuros da Educação (2019...) – princípios do desenvolvimento sustentável para a educação. Aprender a se transformar (UNESCO); e 3) Conferência Mundial de Educação Superior (CMES2022) – aprendizagem para o desenvolvimento sustentável. Constrói-se uma espiral de proposições constitutivas desses movimentos destacando a sua interconexão, seus antecedentes históricos e os diversos formatos que foram se constituindo. Constata-se, nesta segunda década do século, a presença marcante do conceito de desenvolvimento sustentável nas proposições da UNESCO, para atingir o desenvolvimento humano sustentável, marcado por uma concepção de humanismo ampliado com extensão ao planeta.
Lncrna FEZf1-as1 negatively regulates ETNK1 to promote malignant progression of renal cell carcinoma
Authors: Lou Jiangyong , Liu Xiaoming , Fan Xiaodong , Xu Xiaoming , Wang Zhichao , Wang Liqun
Published: October 2022

Background: To explore the role of LncFEZF1-AS1 in renal cell carcinoma (RCC) tissues and cells, and the possible molecular mechanism. Methods: Expressions of LncFEZF1-AS1 in RCC tissues and adjacent ones were detected. The association of LncFEZF1-AS1 level with clinical data of RCC patients was also analyzed. Besides, the differential expressions of LncFEZF1-AS1 in a variety of RCC cell lines were also determined. Then the LncFEZF1-AS1 knockdown model was constructed in RCC cell line to further determine the influences of LncFEZF1-AS1 on the proliferative ability and migration of RCC cells through CCK8 and Transwell experiments. Furthermore, luciferase reporter gene experiment were used to validate the combination of LncFEZF1-AS1 to ETNK1. Results: Results suggested that expression of LncFEZF1-AS1 was noticeably higher in RCC tumor tissues and the RCC cells. Clinical pathological data analysis also suggested that high LncFEZF1-AS1 expression was in correlation with the pathological stage and the incidence of distant metastasis in RCC patients, and the poor overall survival rate. In vitro experiments demonstrated that knocking down of LncFEZF1-AS1 markedly repressed the proliferation and migration of RCC cell lines. Bioinformatics suggested that LncFEZF1-AS1 can interact with the downstream target gene ETNK1, which was confirmed by the luciferase reporter gene experiments. Western Blot results revealed that knocking down of LncFEZF1-AS1 markedly enhanced ETNK1. qRT-PCR analysis indicated that ETNK1 level was under-expressed in RCC tissues and in negative correlation with LncFEZF1-AS1. Further experiments suggested that knockdown of ETNK1 partially reversed the inhibitory effects of LncFEZF1-AS1 silencing on the proliferative and migrative abilities of RCC cells. Conclusions: LncFEZF1-AS1 could facilitation the proliferative and migration of RCC cells by regulating the expression of ETNK1. Therefore, FEZF1-AS1 might function as a cancer-promoting factor and possible new therapeutic target for RCC.
Risk Factors for Depressive Disorders after Coming through COVID-19 and Emotional Intelligence of the Individual
Authors: Zhylin Mykhailo , Makarenko Svitlana , Kolohryvova Nadia , Bursa Andrii , Tsekhmister Yaroslav
Published: October 2022

Background: COVID-19 has caused many new challenges for humanity worldwide. The pandemic united society from different regions of the planet in the experience of experiencing the epidemic, particularly complications after the disease, including the development of depression and increased anxiety. The study aimed to identify risk factors for depression among people who came through moderate and severe coronavirus infection and to substantiate the role of emotional intelligence as a factor that prevents depressive disorders.

Methods: The author’s questionnaire, Beck’s Depression Inventory (BDI-II), Emotional Intelligence Test (EmIn), and narrative analysis were used for this purpose.

Results: The separate groups of respondents, distributed according to their socio-economic status, were studied for their level of general emotional intelligence. High indicators of emotional intelligence of public sector employees who are in constant social interaction were recorded. A group of entrepreneurs focused on solving pragmatic financial and economic problems had low emotional intelligence. Severe depression symptoms were also the most common among a group of entrepreneurs. A decreased level of emotional intelligence in groups of female public sector employees and increased depressive symptoms were empirically found. The physiological factor was the most significant in contributing to depression.

Conclusions: The main advantage of the study is the empirical justification of the role of internal anti-stress regulation mechanisms, with the development of emotional intelligence as one of the tools. Prospects for further research include improving diagnostic tools and studying the longer-term consequences of coronavirus disease, particularly in different groups of respondents.
Does Clinical Evidence of Heterogeneity Impact Treatment Selection? A Case Study of Abiraterone for Metastatic Prostate Cancer
Authors: Jiao Boshen , Nyame Yaw A. , Carlson Josh J. , Garrison Louis P. , Basu Anirban
Published: October 2022

Background: Two pivotal randomized controlled trials (RCTs) demonstrate that abiraterone acetate + prednisone (AAP) combined with androgen deprivation therapy (ADT) significantly extends the survival of men with metastatic hormone-sensitive prostate cancer (mHSPC) compared with ADT alone. Their subgroup analyses indicate that the survival benefit is significant for younger men but not older men. We aimed to assess whether publication of the RCTs was associated with differential real-world AAP utilization by age groups. Methods: Using TriNetX electronic medical records data collected from 43 healthcare organizations across the United States, we performed a difference-in-differences event study among men with newly diagnosed mHSPC observed from June 2014 to June 2019. Eligible subjects were identified based on a comprehensive published algorithm. We analyzed the change in utilization rate of AAP before versus after publication of the RCTs among men aged <70 years versus ≥70 years, adjusting for demographic factors and clinical conditions. Results: Our study included 6,888 men with newly diagnosed mHSPC with 12,738 observations, of whom 46% were aged <70 years. The prepublication trends of AAP utilization were similar between the age groups, whereas publication of the RCTs was associated with a 3.5% higher adjusted uptake rate of AAP among younger men (95% CI, 1.2%–5.8%) relative to older men. This estimate reflects an uptake rate nearly 3 times higher than would have been expected had younger men followed the same utilization trends as older men. The estimates remained consistent throughout the postpublication period. Conclusions: Our study suggests that publication of the RCTs was associated with faster uptake of AAP among younger versus older men with newly diagnosed mHSPC, despite the absence of clinical guidance for differential treatment selection. This finding highlights the importance of confirmatory studies among older men, considering the uncertainties of subgroup analyses in RCTs.
Ungeperspektiver på læringsfællesskaber i FGU
Authors: Schwartz Ida , Hansen Lene Kullen , Nielsen Morten Kromann , Mardahl-Hansen Tilde
Published: October 2022

ResuméFGU er en relativt ny uddannelse skabt for at understøtte, at unge i udsatte positioner kommer videre fra folkeskole til uddannelse eller arbejde. FGU modtager elever med forskellige negative erfaringer for deltagelse i skole eller uddannelse. Der er knyttet store uddannelsespolitiske ambitioner til FGU-uddannelsen om at skabe læringsfællesskaber, der kan rumme elever med mange forskellige forudsætninger. Artiklen tager afsæt i et teoretisk begreb om læring gennem social deltagelse og sætter gennem analyser af unges perspektiver på deres deltagelse i en FGU-uddannelse fokus på, hvordan unge (igen) kommer i ’position som lærende sociale deltagere’. Der tages udgangspunkt i en forståelse af social udsathed som situeret i komplekse sociale sammenhænge, hvor ikke mindst uddannelsesmæssige deltagelsesbetingelser spiller ind. Dermed anlægges et syn på social udsathed som en livssituation i stadig forandring afhængig af skiftende sociale betingelser. Artiklen analyserer, hvordan unge tillægger skolelivets fællesskaber, læringsaktiviteter og egen indflydelse betydning. En kontekstuel tilgang knytter udsathed til positioner i social praksis og det skærper et blik for, hvordan unge overskrider oplevelser af personlig usikkerhed og sårbarhed gennem aktiv medskabelse af de uddannelsesmæssige læringsfællesskaber, de er en del af.
AbstractLearning Communities seen from the Perspectives of Young AdultsFGU is a relatively new education which was created for the purpose of supporting young people in exposed positions in their further path – from lower secondary school to education or work. FGU receives students with various negative experiences from school or educational participation. The FGU education is linked with considerable education-policy ambitions with respect to the creation of learning communities capable of embracing students of many different educational backgrounds. The article takes a theoretical concept on learning through social participation as its point of departure and, by way of analyses of young people’s perspectives on their participation in the FGU education, it focuses on how young people can (once again) be brought into ‘position as learning social participants’. The point of departure is an understanding of social vulnerability as situated in complex social contexts in which not least educational participation relations come into play. From a theoretical perspective on learning through social participation, the article analyses how young people will attach meaning to school-life communities, learning activities and their own influence. A contextual understanding of vulnerability which, linked with positions within social practice, offers a prospect of how young people have the possibilities of exceeding personal experiences of insecurity and vulnerability through contributing to the communities of school life.
Hjemløs
Authors: Mortensen Klaus P.
Published: October 2022

Se kort indholdsbeskrivelse i nummerets forord.
CLIL og egnede værktøjer
Authors: ANDERSEN KENT
Published: October 2022

Undervisningsmetoder, som ligner det, der senere er blevet kaldt CLIL, har været anvendt....
Sprog og kultur i den nye folkeskolereform
Authors: Kristjansdottir Bergthora
Published: October 2022

Det kan næppe være forbigået ret mange, at en ny folkeskolereformer trådt i kraft her ved [...]
Det arrangerede kulturmøde
Authors: Galal Lise Paulsen , Hvenegård-Lassen Kirsten , Tranekjær Louise
Published: October 2022

Gymnasieelever tager på udveksling i udlandet for at blive globale medborgere. Danskere med muslimsk og kristen baggrund deltager i fælles arrangementer for at lære hinanden bedre at kende. Integra- tionsmedarbejdere sendes på kursus i at håndtere flygtninge. (...)
International Baccalaureate
Authors: Møllmann Else Marie , Vinten Inge , Østergaard Inger
Published: October 2022

Se kort indholdsbeskrivelse i nummerets forord.
“It’s just another added layer of difficulty”: Language access equity and inclusion in pediatric interpreted medical encounters — Provider and interpreter perspectives
Authors: Olen Amy , Lim Paulina S. , Balistreri Kathryn A. , Davies W. Hobart , Scanlon Matthew C. , Rothschild Charles B.
Published: October 2022

Limited English proficient or language-diverse patients and families in pediatric interpreted medical encounters (IME) are susceptible to health disparities and inequities in the US compared to English proficient patients and families in language-concordant medical encounters. Policies to improve access to language services intend to bridge this gap, yet evidence suggests that significant inequities still exist. This study explores perspectives of interpreters and pediatric critical care medical providers to better understand the complexities of IME in pediatric settings. Qualitative data were analyzed from two interview studies with medical interpreters and providers using thematic coding and inductive analysis. Several factors were identified by both interpreters and medical providers that negatively affected communication, equity, and inclusion. These included systems-level factors (e.g., time constraints and language variety), interpersonal factors (e.g., difficulties with communication and mistrust), and intrapersonal factors (e.g., implicit biases and judgements). These results highlight multiple layers of potential inequities which adversely affect patients and families in pediatric IME.
Unfolding occupational boundary work: Public service interpreting in social services for structurally vulnerable migrant populations in Finland
Authors: Nordberg Camilla , Kara Hanna
Published: October 2022

This article explores occupational boundaries in the context of public service interpreting with structurally vulnerable migrant populations, raising questions about what kind of knowledge becomes valued and what kind of intersectional hierarchies are produced within a transforming social service landscape. Drawing on conceptualisations of boundary work and occupational (mis)recognition, we analyse written and oral diaries produced by public service interpreters in spring 2022. The research participants are of diverse professional and ethnic backgrounds and based in different urban and rural regions of Finland. We show how occupational misrecognition, at the structural and at the floor level, impacts on the possibilities of public service interpreters’ professional and ethical conduct. As such, it ultimately also affects the right to fair and equal treatment for structurally vulnerable service users who are dependent on interpreter-mediated social services.
Language policies for social justice — Translation, interpreting, and access
Authors: Monzó-Nebot Esther , Mellinger Christopher D.
Published: October 2022

This is the introduction to the special issue on Language Policies for Social Justice. Using the ultimatum game as a lens through which to view resource allocation and language policies, the guest editors argue that dominant language communities are placed in an advantageous position to decide on the offer to be made to non-dominant language communities. This approach allows fairness norms to be explored in traditionally or emergently multilingual communities by drawing on translation and interpreting studies scholarship. Finally, the guest editors articulate how the articles in the special issue are positioned to advance social justice. It is argued that the articles achieve this aim by articulating how translation and interpreting studies scholarship can contribute at the law-making, policy-making, and practice level, impacting translation and interpreting practitioners as well as professionals working in situations which necessitate mediation and public services users.
Presentació de Just. Journal of Language Rights & Minorities. Revista de Drets Lingüístics i Minories
Authors: Tasa Fuster Vicenta , Castelló-Cogollos Rafael , Monzó-Nebot Esther
Published: October 2022

Naix la revista Just. Journal of Language Rights & Minorities. Revista de Drets Lingüístics i Minories. En aquestes pàgines us expliquem què vol ser.
Sobre os sentidos da crise na crítica de Husserl ao naturalismo
Authors: Tourinho Carlos Diógenes Côrtes
Published: October 2022

O presente artigo aborda dois sentidos do tema da crise em Husserl: um teórico e outro prático. O primeiro result a do projeto de naturalização da consciência e das ideias, ao passo que o segundo está relacionado a uma crise da humanidade europeia. O artigo mostra que o diagnóstico husserliano da crise somente se torna possível na medida em que o exercício da tarefa crítica denuncia os contrassensos da doutrina naturalista nos sentidos teórico e prático, revelando a relação indissociável entre ambos.
Nietzsche e a arte
Authors: Ferreira de Mendonça Adriany
Published: October 2022

O objetivo deste artigo é discutir a maneira como Nietzsche coloca a questão do niilismo em seus textos preparados para publicação, sobretudo em alguns daqueles que se concentram entre 1886 e 1888. Neste momento mais tardio de sua obra, o autor formula suas hipóteses genealógicas acerca dos valores morais, e evidencia o vínculo existente entre a moralidade de origem socrático-platônica e os valores cristãos que marcam fortemente a cultura ocidental. A modernidade, ao atualizar e oferecer novas roupagens às formas de detração da vida engendradas pelos ideais ascéticos, é qualificada por Nietzsche como niilista por excelência. Pretende-se discutir em que medida, ao analisar o niilismo como fator determinante para se caracterizar a própria modernidade, e ao indicar com sua genealogia que todas as grandes coisas pereceriam por si mesmas, segundo a lei de uma “necessária ‘autossuperação’”, Nietzsche abre a possibilidade de se pensar a arte e a sua gaia ciência como potentes forças contrárias ao niilismo e aos ideais ascéticos. A arte, sendo o lugar do culto ao não-verdadeiro e instância plenamente afinada ao próprio movimento de criação e destruição de formas que compõe a vida, seria o vetor central através do qual a gaia ciência nietzschiana poderia contribuir para a efetivação de uma transvaloração dos valores.