bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of the Willingness to Promote Advance Care Planning among Nurses in Palliative Care Settings in Yogyakarta, Indonesia
Authors: Sari Ike Wuri Winahyu , Hidayati Rizqi Wahyu
Published: December 2021

Background: While previous studies showed that oncology nurses were highly inclined to promote advance care planning (ACP), there is a limited study focusing on ACP that concerns the willingness to promote ACP among palliative nurses in Indonesia. This issue needs to be investigated to determine the causative factors so that interventions for nurses can be arranged to improve ACP in Indonesia.Purpose: This study aimed to identify predictors of the willingness to promote ACP among nurses in palliative care settings.Methods: This study used a descriptive-analytical design with a cross-sectional approach. A total of 150 registered nurses with at least one year of experience were purposively recruited. Data were collected using the Indonesian version of the willingness to promote ACP instrument (I-WPACP) with a possible score range of 24 to 120; the higher the score, the higher the willingness to promote ACP. The descriptive statistic, independent t-test, Pearson correlation test, Spearman rank correlation test, and multiple linear regression test were used to analyze the data.Results: The willingness to promote ACP showed a mean score of 84.73±9.36. The score indicates a high willingness to promote ACP. The experience of receiving palliative care education became a related factor as well as the most closely related factor to the willingness to promote ACP in the palliative care settings (β=0.184; p=0.028).Conclusion: The willingness to promote ACP among nurses is high and closely related to their experience of receiving education about palliative care. Education about palliative care and training on ACP needs to be developed so that nurses can discuss ACP with patients and family caregivers.
Unwanted taxpayers
Authors: Paszti Peter Gergely
Published: December 2021

While a relatively large amount of research is being conducted in prisons around the world, the number of searches allowed in penitentiary institutions in Hungary is very low. The problem is not only with the number of researches allowed, but also that in many cases the researcher is forced to make serious trade-offs to obtain a permit. And even if that wasn’t enough to get the researcher to refrain from doing his or her research, the penitentiary is constantly making it harder to complete it. In this short paper, I would like to show how my reintegration research has been hampered. It is as if the goal is to prevent convicts from receiving help for a successful reintegration.
From Mao Zedong to Xi Jinping: China towards a New Era
Authors: Tian Robert Guang , Yangkuo Li
Published: December 2021

China is a large socialist developing country, and the CPC is the core force chosen by the Chinese people to lead it. Mao Zedong was the creator of the Communist Party of China and the People's Republic of China. He led the Chinese people to complete the cause of liberation, carried out socialist construction and began to march toward modernization, forming the great Mao Zedong Thought. Xi Jinping inherited Mao Zedong Thought. He put forward the strategic vision of realizing the Chinese Dream, the great rejuvenation of the Chinese nation. In the new international environment and under the new historical conditions, Xi Jinping has formed a series of highly relevant and continuous theoretical thoughts. His theoretical thoughts have become the guiding ideology for China to become prosperous and strong and make greater global contributions. This paper Outlines the historical process of China from Mao Zedong to Xi Jinping and discusses Xi Jinping's main theoretical ideas.
Assessing the Challenges and Coping Strategies Adopted by Street Children of School Going Age in the Tamale Metropolis: Policy Implications
Authors: Mohammed Gunu Ibrahim Mohammed , Siibaway Mohammed , Sulemana Achanso Adams , Sulemana Achanso Adams
Published: December 2021

Children form the foundation of every society. They are expected to be trained, supported and guided to become responsible to the society. In Ghana, the 1992 constitution (Article 28, clause 1), the children’s Act (Act 560) and the Child Rights Regulations 2002 (LI.1705) are among the measures put in place to promote the wellbeing of children in the country. However, there are significant numbers of children who are living in many city streets in Ghana including the Tamale metropolis. These street children are living the life that has the tendency to affect their physical and mental development. This paper examines the challenges street children in Tamale face and their coping strategies. It also explores various policy options to ensure their continuous education. The study used a case study design to collect both qualitative and quantitative data. Findings of the research show that street children encounter challenges related to accommodation, education, sexual abuse, health, security, and malnourishment and in some cases death. The paper also found that street children adopt variety of strategies including relying on self-medication, hawking and the formation of networks to cope with the various challenges they encounter on the street. However, the education of these children is a big challenge. It is in the light of this, that the paper calls on relevant key stakeholders to put in serious efforts towards tackling the education of street children and child streetism in the Tamale metropolis to ensure access and quality of education of these children.
Tekst artystyczny jako przedmiot dociekań językoznawczych
Authors: Sadowska-Dobrowolska Katarzyna
Published: December 2021

Artykuł poświęcony jest zaprezentowaniu możliwości wykorzystania językoznawczych narzędzi opisu zjawisk semantycznych do analizy i interpretacji tekstu artystycznego. Na wstępie Autorka omawia zmiany koncepcji znaczenia, będące skutkiem rozwoju językoznawstwa kognitywnego, oraz konsekwencje tych zmian, tj. poszukiwanie nowej formuły definicji i zainteresowanie zjawiskiem kreacji językowej. Następnie przypomina zależności istniejące między konwencją i kreacją, a także wskazuje rolę analizy tekstów artystycznych w badaniach poświęconych rekonstrukcji językowego obrazu świata. W dalszej kolejności opisuje korzyści, jakie płyną z uwzględniania takich analiz w pracach językoznawczych. Zadaje pytania o możliwość zastosowania metodologii językoznawczych w analizach tekstów i stawia hipotezę o ich przydatności w wyjaśnianiu mechanizmów kreacji językowej i w ustalaniu, jaki sposób uzyskany został końcowy efekt semantyczny analizowanego tekstu. Następnie skupia się na dwóch wybranych teoriach językoznawczych, tj. na teorii ram interpretacyjnych Charlesa Fillmore’a oraz teorii integracji pojęciowej Gilles’a Fouconniera i Marka Turnera. Przechodząc do części analitycznej pracy, w kolejności omawia teoretyczne założenia obu koncepcji badawczych i prezentuje, jak za ich pomocą można przeprowadzić analizę i interpretację wybranego teksu artystycznego. Etapy analizy prezentuje w formie tabeli i schematu integracji pojęciowej, co pozwala dokładniej prześledzić jej przebieg. Zastosowanie językoznawczych narzędzi opisu kreatywnych zjawisk językowych pozwala Autorce ustalić relacje między komponentami sensotwórczymi tekstu, precyzyjnie wyjaśnić mechanizmy obecnej w nim kreacji oraz określić końcowy efekt semantyczny zawarty w omawianym utworze. Sformułowane wnioski opowiadają się za słusznością włączenia analizy językoznawczej do badań nad tekstem.
Monitorowanie własnej motywacji w nauczaniu zdalnym
Authors: Wnuk Kamil
Published: December 2021

The article discusses new forms of youth self-control in the Internet space, which are actively developing in the postdigital culture. The text analyzes the form of social activism during the coronavirus syndemia, which the author defined as self-motivation monitoring. The use of this cognitive category prompts reflection on specific examples – the Internet users, and it allows to capture the self-control mechanism’s characteristics of the young generation community on the Internet. The educational discovery of the discussed phenomenon made it possible to notice that there are significant problems in distance learning, and the communities’ cooperation in the network is related to the educational process of creating the common good.
Trener sportowy dorosłych osób z niepełnosprawnością intelektualną jako ich przywódca w społeczeństwie1
Authors: Świstek Artur
Published: December 2021

The article in a person representing the trait of an individual trait and a person of a sports trainer with intellectual disability and a personality traits leader with an intellectual personality and a personality traits leader with an intellectual personality.
Dyspozycje aksjologiczne nauczyciela – perspektywa ucznia
Authors: Czapla Małgorzata
Published: December 2021

The articles justifies the need for constant care for the axiological dimension of education. The habitus of the modern teacher was analyzed in the perspective of axiological dispositions. The author’s reconstructions of the respondents’ views concerning their preferences regarding observable and repetitive teachers’ behavior were categorized. These behaviors were indicators of the values which guided teachers in their work with students. An attempt was made to determine which axiological properties of teachers, expressed in the praxiological dimension, are particularly valued by today’s youth. Analysis of the frequency of indications of the preferred teachers’ behaviors helped to establish the hierarchy of these properties. The results of the diagnosis carried out on a sample of 903 respondents showed that teachers’ pedagogical tactfulness, subject knowledge and good organization of work are mostly appreciated and expected by young people. In addition, attempts were made to identify differences in the respondents’ preferences due to their interest profile, expressed in the choice of a specific field of academic studies. It has been established that it is the factor which differentiates students’ preferences in relation to the teacher’s axiological attributes. Significant relationships have been observed and the conclusions made valuable implications for pedeutology.
Understanding Israeli Start-Up Founders in the context of “Tikkun Olam”
Authors: Persoff Tova
Published: December 2021

Context impacts a start-up founder’s behavior, activities and choices. This study uses the three founder identities introduced by Fauchart and Gruber (2011) Darwinian, communitarian and missionary to classify Israeli start-up founders who have created diverse products. It presents an innovative context-based interpretation of Tikkun Olam – which in Hebrew means ‘making the world a better place’ as a possible explanation for the relatively large number of Israeli start-up founders who were found to have a hybrid identity.
Attitudes of parents and children towards people with disabilities and their integration into society
Authors: Fuchs Hila
Published: December 2021

This study is part of a broader study that examined the correlation between cognitive, psychological, and behavioural abilities in parents and their children. It focuses on the correlations between attitude to disability and the integration of people with disabilities among parents and their children. This study is a two-part integrated study. In the first part, the data were collected and analysed according to a quantitative methodology to examine access to disabilities, the integration of people with disabilities, and the factors that influence attitudes, feelings, and willingness to integrate with the general population. In the second part, the data were collected and analysed according to a qualitative methodology in order to examine the relationship of attitudes of parents and their children towards people with disabilities and the integration of people with disabilities.
TÉLÉAPPRENTISSAGE EN PHILOLOGIE APRÈS LA PANDEMIE – SERA-T-IL COMME CELUI D’AVANT ?
Authors: Widła Halina
Published: December 2021

At the end of the first semester of the 2019/2020 academic year, we conducted an opinion survey of 50 philology students on their willingness to adopt new pedagogical approaches based largely on digital media. We measured the degree of appreciation of different forms of academic work, including lectures, tutorials and seminars, modified by these approaches. After a year of the COVID-19 pandemic, we investigated the potential revision of views on the practical application of the innovations described in 2020. Our research focused on appreciating the usefulness and effectiveness of the teaching methods analyzed during the initial research, judged through the prism of current experiences.
Cursory Viewpoint on Transnistria as the Focus of the Russian Federation Policy
Authors: Telenko Olha , Prysiazhniuk Yuriy
Published: December 2021

The article outlines cursory viewpoint on Transnistria as the focus of the Russian Federation policy. Russia pursues political interests in Transnistria connected with its geostrategic ambitions on the post-Soviet state. It is revealed that Moscow has a great impact on the life of Transnistria and cooperates with Tiraspol in political, military, social, cultural, and economic spheres. It is discussed that Russian military presence in this de facto state helps not only to control Transnistria but also Moldova concerning its geopolitical choice. In the article Russia’s activity concerning conflict resolution in Transnistria is shown. A special attention is paid to the Kozak Plan aiming at unification of Transnistria and Moldova, according to which too-extensive rights to Transnistria had to be given. Although this plan was not implemented, in fact now its idea is promoted gradually through convergence of Moldova and Transnistria. In the article it is stressed that russification of the region influences on the mood of the population concerning the future status of the region. Social and economic relations between Russia and Transnistria are researched. It is revealed that all three presidents of this de facto state had close ties with the Russian government and coordinated their politics with it. It is discussed that officially Russia supports territorial integrity of Moldova but at the same time it gives comprehensive support of Transnistria. Although it is not declared in the documents, now the Russian Federation favours status quo in Transnistria.
Prospects for China’s BRI and Strategic Influence in the Post-COVID-19 Central Asia
Authors: Khan Furqan
Published: December 2021

COVID-19 brings a momentous decline for global economic activities but its consequences for China’s Belt and Road Initiative (BRI) remains imminent. Despite the economic shocks of the Pandemic, BRI remains a top priority for China which allows Beijing to improve regional connectivity and expand its economic outreach far off to Europe and the American shores. On the other hand, the Central Asian economies are hard hit by the pandemic with a reduced regional trade, decline in oil prices and its commodities, deep slump in remittances, and the slackening manufacturing ability. The revival of BRI and its immediate success is desirable to the COVID-19 hit Central Asian economies. This is because BRI has bound the region together in terms of infrastructural development where China, under the rubric of BRI, is spearheading major developmental projects, pouring investment in energy sector, offering debt, and improving bilateral trade with regional economies. For this reason, the Central Asian countries desire immediate revival of close economic cooperation which could links the economic fortunes of regional countries to Beijing and brings the BRI to the fore in regional priorities. The paper highlight the impact of COVID-19 over Central Asian economies, the significance BRI for the region; its geopolitical importance for China; and the growing Chinese influence in the post-Pandemic Central Asia using Bourdieu’s Theory of Symbolic Power. Finally, using qualitative content analysis, the paper argues that the economic impact of COVID-19 are short-term and of limited nature and it will only increase prospects for BRI in the post-Pandemic Central Asia with vital strategic utilities for China’s geopolitical profile in the region.
Social Efficiency of Entry in an Open Economy
Authors: Han Tien-Der , Haque M. Emranul , Mukherjee Arijit
Published: December 2021

We show that cost asymmetry between the domestic and foreign firms is not necessary for the occurrence of insufficient entry in the domestic country. This result provides a rationale for pro-competitive domestic policies even in the absence of cost asymmetries among the domestic and foreign firms. However, if significant demand comes from foreign countries, and the market structures are determined endogenously in the domestic and foreign countries, domestic-entry in an open economy might not be insufficient, implying that foreign competition might not reduce the importance of anti-competitive domestic policies.
Modelling and performance analysis for cumene production process in a four-layer packed bed reactor
Authors: Mundakkal Lakshmanan Vinila , Kallingal Aparna , Sreekumar Sreepriya
Published: December 2021

A mathematical model is developed and designed for the cumene reactor in cumene production process in Hindustan Organic Chemicals Limited (HOCL), Kochi with improved operating conditions. High purity cumene is produced by the alkylation of benzene with propylene in this catalytic condensation process where solid phosphoric acid (SPA) is used as the catalyst. The mathematical model has been derived from mass and energy balance equations considering the reactor as fixed packed bed reactor and two different numerical methods are presented here to solve the modelling equations. The explicit finite difference method (FDM) involves the approximation of derivatives into finite differences, and in the other one, orthogonal collocation (OC), Ordinary Diffeential Equations (ODEs) are formed at the collocation points and are solved using Runge–Kutta fourth order numerical scheme. Here the analysis shows that the predictions from the model are in good alignment with the plant data. The combined feed has the optimum value of 1:2:8 for propylene, propane and benzene and the profiles of temperature and concentration can be obtained along the reactor. The model has been implemented in COMSOL Multiphysics as a packed bed reactor using the same parameters collected from the plant of study. It has been found that the reaction occurs at a satisfactory level even with a low temperature than the reactor temperature at the plant by changing the catalytic particle size. The reaction performance is also analysed for the physical properties like porosity and catalyst size.
Advances and challenges in the development of nanosheet membranes
Authors: Kadja Grandprix T. M. , Himma Nurul F. , Prasetya Nicholaus , Sumboja Afriyanti , Bazant Martin Z. , Wenten I G.
Published: December 2021

The development of highly efficient separation membranes utilizing emerging materials with controllable pore size and minimized thickness could greatly enhance the broad applications of membrane-based technologies. Having this perspective, many studies on the incorporation of nanosheets in membrane fabrication have been conducted, and strong interest in this area has grown over the past decade. This article reviews the development of nanosheet membranes focusing on two-dimensional materials as a continuous phase, due to their promising properties, such as atomic or nanoscale thickness and large lateral dimensions, to achieve improved performance compared to their discontinuous counterparts. Material characteristics and strategies to process nanosheet materials into separation membranes are reviewed, followed by discussions on the membrane performances in diverse applications. The review concludes with a discussion of remaining challenges and future outlook for nanosheet membrane technologies.
Essential changes in the composition of copper alloys reveal technological diversities in the transition from the Earliest Iron Age to the Early Roman period in Lithuania
Authors: Bliujienė Audronė , Petrauskas Gediminas , Bagdzevičienė Jurga , Babenskas Evaldas , Rimkus Tomas
Published: December 2021

In the context of archaeometallurgical studies of copper alloys, it is relevant to record the essential
changes in the elemental composition of copper alloys that occur during changes in technology
and transitions in human history. This article presents the shift in the elemental composition of
copper alloy from bronze-based alloys to brass ones during essential changes in archaeological
material which happened at the turn of the Earliest Iron Age (500–1 BC) and the Early Roman
period, from the 1st century BC to the middle of the 1st century AD. As early as the 2nd and
1st centuries BC, in the Antique world and the Roman Empire and its provinces, brass was already
starting to partly replace bronze. Even if the Earliest Iron Age is the least knowable period
in Lithuanian prehistory, the few pieces of jewellery attributed to this period show the changes
in the composition of the copper alloy. The territorial growth of the Late Antique world and
internal contacts within the Barbaricum led to the expanding strength of commodities, including
raw materials, technologies, cultural ideas and ideological attitudes. Goods and ideas spread
throughout the vast barbarian lands, and eventually reached the forest zone of northeast Europe.
Sudden changes during the Early Roman period were first of all connected with the development
of settlement structure, and this has therefore made it possible to identify some major places of
the production of artefacts and partly changed directions of exchange. All this was accompanied
by the emergence of new jewellery types produced by skilled jewellers according to sophisticated
techniques. These changes are clearly visible in Early Roman period Lithuanian archaeological
material, including the elemental composition of copper alloys. The present article uses X-ray
fluorescence (XRF) spectrometry to investigate the composition of copper alloys. Radiography
was used to understand the construction of artefacts, and to assess the degree of their inner corrosion
and sophisticated manufacturing techniques. Solder samples were taken from the surfaces
of several finds, and were analysed by qualitative microchemical analysis.
Between mighty hillforts: a multi-method study of Laukskola Bronze Age settlement pottery
Authors: Visocka Vanda , Gunnarssone Alise , Kalniņš Mārcis , Plankājs Eduards
Published: December 2021

This paper presents the results of a multi-method study of the Laukskola Late Bronze Age open
field settlement pottery assemblage. The aim of the study was to describe the technical and stylistic
aspects of Laukskola pottery, and their relationship with the nearby hillfort material. The production
tendencies and their role in the function of the pottery were also analysed. Macroscopic
analysis combined with ceramic petrography, reflective transformation imaging, and wavelength
dispersive X-ray fluorescence spectroscopy were conducted in the analysis of the pottery. Nearby
clay resources were surveyed and further analysed for provenance interpretations. The results of
the study show that Laukskola pottery was locally produced by using highly plastic sandy moraine
clay, tempered with granitic rock and quartzite. Stylistically, the pottery combined local and nonlocal
elements. The function corresponds with the visual parameters and choices for production.
The Uniform and Nonuniform Nature of Slow and Rapid Scaling in Embryonic Motoneurons
Authors: Pekala Dobromila , Wenner Peter
Published: December 2021

Neurons regulate the strength of their synapses in response to a perturbation to stabilize neuronal signaling through a form of homeostatic plasticity known as synaptic scaling. The process of scaling has the potential to alter all of a cell's miniature postsynaptic current (mPSC) amplitudes by a single multiplicative factor (uniform scaling), and in doing so could change action potential-dependent or evoked synaptic strength by that factor. However, recent studies suggest that individual synapses scale with different scaling factors (nonuniform). This could complicate the simple multiplicative transform from mPSC scaling to the evoked response. We have previously identified a slow AMPAergic and GABAergic synaptic scaling in chick embryo motoneurons following 2 din vivoperturbations inhibiting neuronal activity or GABAAR function, and now show a rapid form of scaling following NMDAR blockadein vitro. Slow GABAergic scaling appeared to be of a classical uniform pattern. Alternatively, other forms of rapid and slow scaling demonstrated a uniform and nonuniform component in their mPSC amplitude distributions. Slow and rapid AMPAergic scaling was mediated by insertion of GluA2-lacking AMPA receptors. The nonuniform pattern of scaling may contribute to the observed complexity of the changes in evoked responses. Scaling-induced changes in mPSC amplitudes were not associated with changes in probability of release (Pr). Together, our results demonstrate a new rapid form of scaling in embryonic motoneurons, that slow and rapid scaling is not purely uniform, and that upscaling does not translate to an increase in evoked responses in a simple manner.

SIGNIFICANCE STATEMENTDifferent forms of homeostatic plasticity are thought to play a critical role in maintaining neural function. For example, altering the amplitudes of spontaneous currents through a form of homeostatic plasticity known as synaptic scaling could affect evoked transmission; however, this is rarely tested. Here we demonstrate two forms of scaling and show that in many cases synaptic strength scales differently for distinct synapses within an embryonic motoneuron. These results have functional consequences for evoked synaptic strength and suggest that, like Hebbian plasticity, scaling can change relative synaptic strengths within a cell. Furthermore, our results demonstrate how different forms of homeostatic plasticity influence neuronal communication as the nascent spinal network is first established in the embryonic period.
Collagen VI Regulates Motor Circuit Plasticity and Motor Performance by Cannabinoid Modulation
Authors: Lam Daniel D. , Williams Rhîannan H. , Lujan Ernesto , Tanabe Koji , Huber Georg , Saw Nay Lui , Merl-Pham Juliane , Salminen Aaro V. , Lohse David , Spendiff Sally , Plastini Melanie J. , Zech Michael , Lochmüller Hanns , Geerlof Arie , Hauck Stefanie M. , Shamloo Mehrdad , Wernig Marius , Winkelmann Juliane
Published: December 2021

Collagen VI is a key component of muscle basement membranes, and genetic variants can cause monogenic muscular dystrophies. Conversely, human genetic studies recently implicated collagen VI in central nervous system function, with variants causing the movement disorder dystonia. To elucidate the neurophysiological role of collagen VI, we generated mice with a truncation of the dystonia-related collagen α3 VI (COL6A3) C-terminal domain (CTD). TheseCol6a3CTTmice showed a recessive dystonia-like phenotype in both sexes. We found that COL6A3 interacts with the cannabinoid receptor 1 (CB1R) complex in a CTD-dependent manner.Col6a3CTTmice of both sexes have impaired homeostasis of excitatory input to the basal pontine nuclei (BPN), a motor control hub with dense COL6A3 expression, consistent with deficient endocannabinoid (eCB) signaling. Aberrant synaptic input in the BPN was normalized by a CB1R agonist, and motor performance inCol6a3CTTmice of both sexes was improved by CB1R agonist treatment. Our findings identify a readily therapeutically addressable synaptic mechanism for motor control.

SIGNIFICANCE STATEMENTDystonia is a movement disorder characterized by involuntary movements. We previously identified genetic variants affecting a specific domain of the COL6A3 protein as a cause of dystonia. Here, we created mice lacking the affected domain and observed an analogous movement disorder. Using a protein interaction screen, we found that the affected COL6A3 domain mediates an interaction with the cannabinoid receptor 1 (CB1R). Concordantly, our COL6A3-deficient mice showed a deficit in synaptic plasticity linked to a deficit in cannabinoid signaling. Pharmacological cannabinoid augmentation rescued the motor impairment of the mice. Thus, cannabinoid augmentation could be a promising avenue for treating dystonia, and we have identified a possible molecular mechanism mediating this.
Distinct Factors Drive the Spatiotemporal Progression of Tau Pathology in Older Adults
Authors: Adams Jenna N. , Harrison Theresa M. , Maass Anne , Baker Suzanne L. , Jagust William J.
Published: December 2021

Mechanisms underlying the initial accumulation of tau pathology across the human brain are largely unknown. We examined whether baseline factors including age, amyloid-β (Aβ), and neural activity predicted longitudinal tau accumulation in temporal lobe regions that reflect distinct stages of tau pathogenesis. Seventy cognitively normal human older adults (77 ± 6 years, 59% female) received two or more18F-flortaucipir (FTP) and11C-Pittsburgh Compound B (PiB) PET scans (mean follow-up, 2.5 ± 1.1 years) to quantify tau and (Aβ). Linear mixed-effects models were used to calculate the slopes of FTP change in entorhinal cortex (EC), parahippocampal cortex (PHC), and inferior temporal gyrus (IT), and slopes of global PiB change. Thirty-seven participants underwent functional MRI to measure baseline activation. Older age predicted EC tau accumulation, and baseline EC tau levels predicted subsequent tau accumulation in EC and PHC. In IT, however, baseline EC tau interacted with Aβ to predict IT tau accumulation. Higher baseline local activation predicted tau accumulation within EC and PHC, and higher baseline hippocampal activation predicted EC tau accumulation. Our findings indicate that factors predicting tau accumulation vary as tau progresses through the temporal lobe. Older age is associated with initial tau accumulation in EC, while baseline EC tau and neural activity drive tau accumulation within medial temporal lobe. Aβ subsequently facilitates tau spread from medial to lateral temporal lobe. Our findings elucidate potential drivers of tau accumulation and spread in aging, which are critical for understanding Alzheimer's disease pathogenesis.

SIGNIFICANCE STATEMENTTo further understand the mechanisms leading to tau pathogenesis and spread, we tested whether baseline factors such as age, amyloid-β pathology, and activation predicted longitudinal tau accumulation in cognitively normal older adults. We found that distinct mechanisms contribute to tau accumulation as tau progresses across the temporal lobe, with initial tau accumulation in entorhinal cortex driven by age and subsequent spread driven by neural activity and amyloid-β. We demonstrate that higher baseline activation predicts increased longitudinal tau accumulation, providing novel evidence that activation-dependent tau production may occur in the human brain. Our findings support major hypotheses generated from preclinical research, and have important translational implications, suggesting that the reduction of hyperactivation may help prevent the development of tau pathology.
Contribution of G-Protein α-Subunits to Analgesia, Hyperalgesia, and Hyperalgesic Priming Induced by Subanalgesic and Analgesic Doses of Fentanyl and Morphine
Authors: Araldi Dionéia , Bonet Ivan J. M. , Green Paul G. , Levine Jon D.
Published: December 2021

While opioids produce both analgesia and side effects by action at μ-opioid receptors (MORs), at spinal and supraspinal sites, the potency of different opioids to produce these effects varies. While it has been suggested that these differences might be because of bias for signaling via β-arrestin versus G-protein α-subunits (Gα), recent studies suggest that G-protein-biased MOR agonists still produce clinically important side effects. Since bias also exists in the role of Gα subunits, we evaluated the role of Gαi/osubunits in analgesia, hyperalgesia, and hyperalgesic priming produced by fentanyl and morphine, in male rats. We found that intrathecal treatment with oligodeoxynucleotides antisense (AS-ODN) for Gαi2, Gαi3, and Gαomarkedly attenuated hyperalgesia induced by subanalgesic dose (sub-AD) fentanyl, while AS-ODN for Gαi1, as well as Gαi2 and Gαi3, but not Gαo, prevented hyperalgesia induced by sub-AD morphine. AS-ODN for Gαi1 and Gαi2 unexpectedly enhanced analgesia induced by analgesic dose (AD) fentanyl, while Gαi1 AS-ODN markedly reduced AD morphine analgesia. Hyperalgesic priming, assessed by prolongation of prostaglandin E2-induced hyperalgesia, was not produced by systemic sub-AD and AD fentanyl in Gαi3 and GαoAS-ODN-treated rats, respectively. In contrast, none of the Gαi/oAS-ODNs tested affected priming induced by systemic sub-AD and AD morphine. We conclude that signaling by different Gαi/osubunits is necessary for the analgesia and side effects of two of the most clinically used opioid analgesics. The design of opioid analgesics that demonstrate selectivity for individual Gαi/omay produce a more limited range of side effects and enhanced analgesia.

SIGNIFICANCE STATEMENTBiased μ-opioid receptor (MOR) agonists that preferentially signal through G-protein α-subunits over β-arrestins have been developed as an approach to mitigate opioid side effects. However, we recently demonstrated that biased MOR agonists also produce hyperalgesia and priming. We show that oligodeoxynucleotide antisense to different Gαi/osubunits play a role in hyperalgesia and analgesia induced by subanalgesic and analgesic dose (respectively), of fentanyl and morphine, as well as in priming. Our findings have the potential to advance our understanding of the mechanisms involved in adverse effects of opioid analgesics that could assist in the development of novel analgesics, preferentially targeting specific G-protein α-subunits.
Demographic, Financial Literacy, and Financial Behavior of Women Working in Manufacturing Industry
Authors: Arofah Anastasia Anggarkusuma , Maharani Destin Alfianika
Published: December 2021

The purpose of this study is to determine the effect of demographic factors and financial literacy on financial behavior of women working in manufacturing industry. Women are the targets of financial literacy due to their involvement in fulfilling the household needs and welfare. This research is quantitative research. Using the questionnaire on 115 respondents in this study from various manufacturing industries in Purbalingga with probability sampling as the technique. While the data analysis technique used Structural Equation Modelling (SEM) PLS 3.0. The findings show that, first, demographic factors contribute positively and significantly towards female workers’ financial behavior with original sample value 0.224 and t-value 2.420 > 1.96; second, financial literacy also contributes positively and significantly towards financial behavior with original sample value 0.256 and t-value 3.251 > 1.96. The higher the demographic factors of female workers, the better their financial management are. Likewise, students with low financial literacy tend to be able to hold back their urges to buy things and use services. Moreover, the significance of financial literacy and demographic factors has important implications for the development of policies that aim to improve financial behaviour among women working in financial education programs.
The Effect of Financial Literacy, Parents’ Social Economic and Student Lifestyle on Students Personal Financial Management
Authors: Novitasari Dewiana , Juliana Juliana , Asbari Masduki , Purwanto Agus
Published: December 2021

The purpose of this study was to analyze the effect of financial literacy, parents’ social economic and student lifestyle on students’ personal financial management. This study used quantitative methods and data analysis techniques of Structural Equation Modeling using SmartPLS 3.0 software. The research sample used a random sampling method. The data used primary data collected through a questionnaire. The number of returned and valid questionnaires was 220 samples. The data was processed by using SEM. The results of the study concluded that financial literacy had a significant effect on students’ personal financial management, student lifestyle had a significant effect on students’ personal financial management, and parents’ social economics had a significant effect on students’ personal financial management. The novelty of this research was the Correlation model of financial literacy, parents’ social economic and student lifestyle on students’ personal financial management. The results of this study can be a reference for further research that can be applied in other organizations.
The Realization of Mood and Modality in the Analytical Exposition of the Undergraduate Students of Tidar University
Authors: Puspitasari Vivanti , Warsono Warsono , Sutopo Djoko
Published: December 2021

Writing can be among the most enjoyable and satisfying activities to measure the ability to produce well-formed sentences. This study dealt with the realization of MOOD and Modality in the analytical exposition of the undergraduate students of Tidar University. Fifteen analytical exposition texts were analyzed to determine how the indicative MOOD, the imperative MOOD, modalization, and modulation were realized in the analytical exposition of undergraduate students of Tidar University. The type of this study is qualitative case study research. This study employed Systemic Functional Linguistics (SFL) based on Suzan Eggins (2004) as a framework since this level of structured language creates meaning that can be sought and identified. There were 511 clauses found in the fifteen analytical expositions. The result revealed several findings: (1) it was found that declarative MOOD was the most dominant of the indicative of MOOD system;  (2) that the imperative MOOD type was not dominant; (3) that probability was more dominant than usuality. There were 73 clauses, or around 97% categorized as a probability, and 2 clauses or about 3% were categorized as the usuality; (4) that the obligation was dominant (14 clauses). Then, no clauses were indicated as the inclination. It was concluded that the realization could be seen from the type of indicative, imperative, modalization, and modulation that were found in the analytical exposition text of the undergraduate students of Tidar University.
Take Action: Give A Hope to Minimize Inequality!
Authors: Lee Jessica
Published: December 2021

From equality to inequality, the equilibrium point fluctuates all the time. How to balance and minimize the negative impact of inequality on the individual’s socioeconomic, educational, psychological, and overall health is critical. Even it is of extremely difficult to realize the real equality, it is still worthwhile to take action to minimize the inequality.
A propósito de series TV y literatura.
Authors: Panico Francesco
Published: December 2021

La mejora cualitativa que ha conocido en los últimos años el universo de las series TV abre para la literatura comparada la posibilidad de nuevos estudios. En este ensayo, exploramos esta posibilidad por medio de la traducción intersemiótica, al enfocarnos en las pérdidas y compensaciones que dan vida a la refundición poética de la novela The haunting of Hill House, de Shirley Jackson, en la teleserie homónima emitida por Netflix. Al mismo tiempo, nos ocupamos de analizar dichas pérdidas y compensaciones a la luz de la tradición gótica, con el fin de evaluar qué papel juegan en la propuesta estética de la versión audiovisual. La importancia de dicha labor radica en que sus resultados, además de participar al diálogo disciplinario propio del universo comparatista, pueden utilizarse para la elaboración de nuevas estrategias didácticas al servicio de la educación literaria.
Ecce homo, los simios y el discurso científico
Authors: Velazquez Alvarado Coral
Published: December 2021

En el siglo XIX el método cientifico repercutió en varios ámbitos como el jurídico, específicamente en la Criminalística, para generar la caracterización del delincuente. En su cruce con la medicina y los estudios antropológicos se fundamentó en los conceptos de degeneración y decadencia. Si bien son teorías ya superadas, en su momento conformaron el discurso hegemónico de las sociedades occidentales. Bajo su influjo, los literatos se dedicaron a narrar casos clínicos y policiacos; encabezados por Edgar Allan Poe influencia fundamenta para los latinoamericanos Ciro B. Ceballos y Leopolgo Lugones, quienes, junto con el norteamericano, buscaron cuestionar los argumentos cientificistas que servían para dominar más que para civilizar. Con este fin se sirven de personajes cercanos a la especie humana, el simio, para representar un Otro que es lo marginal, lo primitivo, lo no-occidental y que les sirvió para relativizar los valores imperantes.
Filología verde y poética de la respiración para un mundo contaminado
Authors: Marrero Henríquez José Manuel
Published: December 2021

La plena conciencia de realizarse en las circunstancias ecológicamente críticas de un siglo XXI plenamente antropocénico ofrece a la filología una excelente oportunidad para renacer de sus cenizas y hacerse tan figuradamente verde como fuerte frente a los estudios culturales que la han ido apeando de su venerable trono. Asentada en el desarrollo especulativo de una poética de la respiración, una teoría general de la literatura de inspiración ecológica, la filología verde se orienta hacia objetivos de interés crítico y áreas de atención académica nuevos y, al hacerlo, contribuye al enriquecimiento de una disciplina que se ha mostrado reticente a la exploración de territorios literarios de indagación científica de inspiración medioambientalista.
El principio de la utilización y participación equitativa y razonable y la protección del medio ambiente en la Convención de Naciones Unidas sobre los cursos de agua internacionales
Authors: Álvarez Arcá Ignacio
Published: December 2021

El principio de la utilización y participación equitativa y razonable es la piedra angular sobre la que se estructura el régimen normativo internacional para la gestión de los recursos hídricos compartidos. En el caso de la Convención sobre el derecho de los usos de los cursos de agua internacionales para fines distintos de la navegación, este principio ostenta una primacía frente al resto de principios y normas sustantivas. En este trabajo de investigación sostenemos que la subordinación jerárquica constituye un impedimento para la protección del medio ambiente y, en definitiva, para la sostenibilidad de los recursos hídricos. Además, la existencia de otro tratado universal que regula la misma materia con una clara vocación de protección ambiental no sólo pone en cuestión esta primacía, sino la propia vigencia de la Convención como instrumento internacional de referencia.
Assessing aquatic enviromnemt quality of the urban water bodies by system analysis methods based on integrating remote sensing data
Authors:   State institution «Scientific Centre for Aerospace Research of the Earth of the Institute of Geological Sciences of the National Academy of Sciences of Ukraine», Kyiv, Ukraine, Fedorovsky O.D. , Khyzhniak A.V. ,   State institution «Scientific Centre for Aerospace Research of the Earth of the Institute of Geological Sciences of the National Academy of Sciences of Ukraine», Kyiv, Ukraine, Tomchenko O.V. ,   State institution «Scientific Centre for Aerospace Research of the Earth of the Institute of Geological Sciences of the National Academy of Sciences of Ukraine», Kyiv, Ukraine
Published: December 2021

The work presents the comprehensive methodology for assessment of the state of the urban aquatic environment such as Lakes Opechen, Verbne, and Redkyne in Kyiv using the methods of system analysis. The methodology includes structural-textural analysis of the satellite images and the method based on statistical criteria. The spectral-texture analysis of the satellite images was used to get input information for remote assessment of reservoirs as index images: Normalized Difference Pond Index (NDPI), Normalized Difference Turbidity Index (NDTI), and Normalized Difference Algae Index (NDAI) computed from the Sentinel-2. The surface temperature distribution was estimated from the Landsat 8. The method based on statistical criteria is used for a detailed assessment of the aquatic environment using the obtained indexed images and the corresponding cartographic representation of the water quality. The probabilistic and statistical approaches were used to present the statistical criterion for recognizing classes of objects based on the results of measuring their informative features. These approaches are used to solve optimization problems in statistical theories of identification and recognition. This method allowed the cartographic representing of the change in the water quality and aquatic ecosystem in accordance with the reference areas of the state of the reservoir in 2017.
The study of the functional state of lipid rafts in the cytoplasmic membrane of Pisum Sativum seedlings under clinorotation
Authors:   M.G. Kholodny Institute of Botany of the National Academy of Science of Ukraine, Kyiv, Ukraine, Artemenko O.A.
Published: December 2021

The results of cytological, biochemical, and molecular biological studies clearly demonstrate the significant influence of microgravity on the main processes of plant development, revealing the mechanisms which underlie the reactions of plant responses to microgravity and ensure their adaptation to this factor. The key role in cell function belongs to the cytoplasmic membrane (CM). First of all, by its qualities and functions, it can play an important role in the adaptation of plants to microgravity. However, data about the effect of altered gravity on the physicochemical properties of CM are limited. Recently, much attention has been paid to the study of functional microdomains of the lipid bilayer that have a specific localization and content of lipids and proteins - lipid rafts. They are defined as a dynamic nanosized, sterol- and sphingolipid-enriched ordered association of specific proteins, in which a metastable resting state can be activated by a combination of specific lipid-lipid, protein-lipid, and protein-protein interactions. There are more and more experimental data that confirm their participation in such live processes as endocytosis, apoptosis, internalization of toxins, bacteria, viruses, etc., as well as their important role in the protective mechanisms of the cell under different stressors. In this work, a fluorescent marker of sterols – filipin and a fluorescent probe laurdan were used to confirm the presence of cholesterol and sphingolipid-enriched lipid ranges in CM. Our results regarding the increase in generalized polarization in the clinorotation conditions correlate with the data obtained in previous studies and indicate the sensitivity of the CM to a longer action of the clinorotation.