bluuebunny/crossref_metadata_2025 huggingface dataset:
Revisiting Therapeutic Strategies for H. pylori Treatment in the Context of Antibiotic Resistance: Focus on Alternative and Complementary Therapies
Authors: Cardos Ioana Alexandra , Zaha Dana Carmen , Sindhu Rakesh K. , Cavalu Simona
Published: October 2021

The prevalence of Helicobacter pylori infection remains significant worldwide and it depends on many factors: gender, age, socio-economic status, geographic area, diet, and lifestyle. All successful infectious diseases treatments use antibiotic-susceptibility testing, but this strategy is not currently practical for H. pylori and the usual cure rates of H. pylori are lower than other bacterial infections. Actually, there is no treatment that ensures complete eradication of this pathogen. In the context of an alarming increase in resistance to antibiotics (especially to clarithromycin and metronidazole), alternative and complementary options and strategies are taken into consideration. As the success of antibacterial therapy depends not only on the susceptibility to given drugs, but also on the specific doses, formulations, use of adjuvants, treatment duration, and reinfection rates, this review discusses the current therapies for H. pylori treatment along with their advantages and limitations. As an alternative option, this work offers an extensively referenced approach on natural medicines against H. pylori, including the significance of nanotechnology in developing new strategies for treatment of H. pylori infection.
Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties
Authors: Kukula-Koch Wirginia , Szwajgier Dominik , Gaweł-Bęben Katarzyna , Strzępek-Gomółka Marcelina , Głowniak Kazimierz , Meissner Henry O.
Published: October 2021

This work aims to assess the recently established anti-inflammatory and antioxidant potential of melatonin of plant origin extracted from the plant matrix as a phytomelatonin complex (PHT-MLT), and compare its activity with synthetic melatonin (SNT-MLT) when used on its own or with vitamin C. For this purpose, a COX-2 enzyme inhibitory activity test, an antiradical activity in vitro and on cell lines assays, was performed on both PHT-MLT and SNT-MLT products. COX-2 inhibitory activity of PHT-MLT was found to be ca. 6.5 times stronger than that of SNT-MLT (43.3% and 6.7% enzyme inhibition, equivalent to the activity of acetylsalicylic acid in conc. 30.3 ± 0.2 and 12.0 ± 0.3 mg/mL, respectively). Higher antiradical potential and COX-2 inhibitory properties of PHT-MLT could be explained by the presence of additional naturally occurring constituents in alfalfa, chlorella, and rice, which were clearly visible on the HPLC-ESI-QTOF-MS fingerprint. The antiradical properties of PHT-MLT determined in the DPPH test (IC50 of 21.6 ± 1 mg of powder/mL) were found to originate from the presence of other metabolites in the 50% EtOH extract while SNT-MLT was found to be inactive under the applied testing conditions. However, the antioxidant studies on HaCaT keratinocytes stimulated with H2O2 revealed a noticeable activity in all samples. The presence of PHT-MLT (12.5, 25 and 50 µg/mL) and vitamin C (12.5, 25 and 50 µg/mL) in the H2O2-pretreated HaCaT keratinocytes protected the cells from generating reactive oxygen species. This observation confirms that MLT-containing samples affect the intracellular production of enzymes and neutralize the free radicals. Presented results indicated that MLT-containing products in combination with Vitamin C dosage are worth to be considered as a preventive alternative in the therapy of various diseases in the etiopathogenesis, of which radical and inflammatory mechanisms play an important role.
Quantification of Corn Adulteration in Wet and Dry-Processed Peaberry Ground Roasted Coffees by UV–Vis Spectroscopy and Chemometrics
Authors: Yulia Meinilwita , Suhandy Diding
Published: October 2021

In this present research, a spectroscopic method based on UV–Vis spectroscopy is utilized to quantify the level of corn adulteration in peaberry ground roasted coffee by chemometrics. Peaberry coffee with two types of bean processing of wet and dry-processed methods was used and intentionally adulterated by corn with a 10–50% level of adulteration. UV–Vis spectral data are obtained for aqueous samples in the range between 250 and 400 nm with a 1 nm interval. Three multivariate regression methods, including partial least squares regression (PLSR), multiple linear regression (MLR), and principal component regression (PCR), are used to predict the level of corn adulteration. The result shows that all individual regression models using individual wet and dry samples are better than that of global regression models using combined wet and dry samples. The best calibration model for individual wet and dry and combined samples is obtained for the PLSR model with a coefficient of determination in the range of 0.83–0.93 and RMSE below 6% (w/w) for calibration and validation. However, the error prediction in terms of RMSEP and bias were highly increased when the individual regression model was used to predict the level of corn adulteration with differences in the bean processing method. The obtained results demonstrate that the use of the global PLSR model is better in predicting the level of corn adulteration. The error prediction for this global model is acceptable with low RMSEP and bias for both individual and combined prediction samples. The obtained RPDp and RERp in prediction for the global PLSR model are more than two and five for individual and combined samples, respectively. The proposed method using UV–Vis spectroscopy with a global PLSR model can be applied to quantify the level of corn adulteration in peaberry ground roasted coffee with different bean processing methods.
Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation
Authors: Kim Hye-Min , Lee Seon-Min , Choi Jungil , Soung Nak-Kyun , Heo Jeong-Doo
Published: October 2021

Bisphenol A (BPA) is a typical environmental endocrine disruptor that exhibits estrogen-mimicking, hormone-like properties and can cause the collapse of bone homeostasis by an imbalance between osteoblasts and osteoclasts. Various BPA substitutes, structurally similar to BPA, have been used to manufacture ‘BPA-free’ products; however, the regulatory role of BPA alternatives in osteoclast differentiation still remains unelucidated. This study aimed to investigate the effects of these chemicals on osteoclast differentiation using the mouse osteoclast precursor cell line RAW 264.7. Results confirmed that both BPA and its alternatives, bisphenol F and tetramethyl bisphenol F (TMBPF), were nontoxic to RAW 264.7 cells. In particular, tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cell staining and activity calculation assays revealed that TMBPF enhanced osteoclast differentiation upon stimulation of the receptor activator of nuclear factor-kappa B ligand (RANKL). Additionally, TMBPF activated the mRNA expression of osteoclast-related target genes, such as the nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CtsK). Western blotting analysis indicated activation of the mitogen-activated protein kinase signaling pathway, including phosphorylation of c-Jun N-terminal kinase and p38. Together, the results suggest that TMBPF enhances osteoclast differentiation, and it is critical for bone homeostasis and skeletal health.
Development of Ginkgo (Ginkgo biloba) Nut Starch Films Containing Cinnamon (Cinnamomum zeylanicum) Leaf Essential Oil
Authors: Kim Boo-Kyoung , Lee Hae-Se , Yang Hee-Su , Song Kyung-Bin
Published: October 2021

There have been many studies on the development biodegradable films using starch isolated from various food sources as a substitute for synthetic plastic packaging films. In this study, starch was extracted from ginkgo (Ginkgo biloba) nuts, which were mainly discarded and considered an environment hazard. The prepared starch (GBS) was then used for the preparation of antioxidant films by incorporating various amounts of cinnamon (Cinnamomum zeylanicum) essential oil (CZEO), which provides antioxidant activity. The prepared GBS films with CZEO were characterized by measuring physical, optical, and thermal properties, along with antioxidant activity (ABTS, DPPH, and FRAP) measurements. With the increasing amount of CZEO, the flexibility and antioxidant activities of the GBS films increased proportionally, whereas the tensile strength of the films decreased. The added CZEO also increased the water vapor permeability of the GBS films, and the microstructure of the GBS films was homogeneous overall. Therefore, the obtained results indicate that the developed GBS films containing CZEO are applicable as antioxidant food packaging.
Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines
Authors: Huang Sheng-Han , Huang Wan-Yu , Zhang Guo-Lun , Yang Te-Fang
Published: October 2021

It was found that 4-hydroxy-2-butenoic ester (11) could not react with 3,4-dihydro-isoquinoline (4a). Individual addition reactions of γ-mercapto-α,β-unsaturated esters (18) and -unsaturated amide (19) with 3,4-dihydroisoquinolines (4) were carried out under appropriate conditions to provide the corresponding thiazolo[2,3-α]isoquinoline derivatives with good yields (up to 87%) and significant diastereomeric selectivity. The mechanism of the crucial reaction was discussed.
A Review of Thermal Property Enhancements of Low-Temperature Nano-Enhanced Phase Change Materials
Authors: Williams Joseph D. , Peterson G. P.
Published: October 2021

Phase change materials (PCMs) are of increasing interest due to their ability to absorb and store large amounts of thermal energy, with minimal temperature variations. In the phase-change process, these large amounts of thermal energy can be stored with a minimal change in temperature during both the solid/liquid and liquid/vapor phase transitions. As a result, these PCMs are experiencing increased use in applications such as solar energy heating or storage, building insulation, electronic cooling, food storage, and waste heat recovery. Low temperature, nano-enhanced phase change materials (NEPCM) are of particular interest, due to the recent increase in applications related to the shipment of cellular based materials and vaccines, both of which require precise temperature control for sustained periods of time. Information such as PCM and nanoparticle type, the effective goals, and manipulation of PCM thermal properties are assembled from the literature, evaluated, and discussed in detail, to provide an overview of NEPCMs and provide guidance for additional study. Current studies of NEPCMs are limited in scope, with the primary focus of a majority of recent investigations directed at increasing the thermal conductivity and reducing the charging and discharging times. Only a limited number of investigations have examined the issues related to increasing the latent heat to improve the thermal capacity or enhancing the stability to prevent sedimentation of the nanoparticles. In addition, this review examines several other important thermophysical parameters, including the thermal conductivity, phase transition temperature, rheological affects, and the chemical stability of NEPCMs. This is accomplished largely through comparing of the thermophysical properties of the base PCMs and their nano-enhanced counter parts and then evaluating the relative effectiveness of the various types of NEPCMs. Although there are exceptions, for a majority of conventional heat transfer fluids the thermal conductivity of the base PCM generally increases, and the latent heat decreases as the mass fraction of the nanoparticles increases, whereas trends in phase change temperature are often dependent upon the properties of the individual components. A number of recommendations for further study are made, including a better understanding of the stability of NEPCMs such that sedimentation is limited and thus capable of withstanding long-term thermal cycles without significant degradation of thermal properties, along with the identification of those factors that have the greatest overall impact and which PCM combinations might result in the most significant increases in latent heat.
The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers
Authors: Freitas Lucas F. , Ferreira Aryel H. , Thipe Velaphi C. , Varca Gustavo H. C. , Lima Caroline S. A. , Batista Jorge G. S. , Riello Fabiane N. , Nogueira Kamila , Cruz Cassia P. C. , Mendes Giovanna O. A. , Rodrigues Adriana S. , Sousa Thayna S. , Alves Victoria M. , Lugão Ademar B.
Published: October 2021

The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so-called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come from their optimal size, which prevents the elimination by the kidneys and enhances their permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore, the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the increased surface area and the selective accumulation in the desired tissues. This property leads to the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor. Finally, they are made so that there is no degradation into toxic byproducts and have a lower immune response triggering. In this article, we intend to review and discuss the state-of-the-art regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate cancer, as they are among the most prevalent worldwide.
Plasmon Enhanced Second Harmonic Generation from ZnO Nanofilms on Vertical Au Nanorod Arrays
Authors: Ma Qiang , Pan Chengda , Xue Yingxian , Fang Zhiyun , Zhang Shiyu , Wu Botao , Wu E
Published: October 2021

Vertically aligned gold nanorod arrays have attracted much attention for their fascinating optical properties. Different from longitudinal surface plasmon wavelength (LSPW) and edge-to-edge spacing of gold nanorods, the role of gold nanorod diameter in plasmonic enhancement ability of vertical gold nanorod arrays has rarely been explored. In this work, we selected gold nanorods with similar LSPW but two different diameters (22 and 41 nm), the optical properties of which are dominated by absorption and scattering cross sections, respectively. The vertically aligned arrays of these gold nanorods formed by evaporation self-assembly are coupled with nonlinear ZnO nanocrystal films spin-coated on their surfaces. It was found that the gold nanorod array with a larger diameter can enhance the second harmonic generation (SHG) of ZnO nanofilm by a factor of 27.0, while it is about 7.3 for the smaller gold nanorod array. Theoretical simulations indicate that such stronger enhancement of the larger vertical gold nanorod array compared with the smaller one is due to its stronger scattering ability and greater extent of near-field enhancement at SHG fundamental wavelength. Our work shows that the diameter of gold nanorods is also an important factor to be considered in realizing strong plasmon enhancement of vertically aligned gold nanorod arrays.
Evaluation of Surface Change and Roughness in Implants Lost Due to Peri-Implantitis Using Erbium Laser and Various Methods: An In Vitro Study
Authors: Secgin-Atar Aslihan , Aykol-Sahin Gokce , Kocak-Oztug Necla Asli , Yalcin Funda , Gokbuget Aslan , Baser Ulku
Published: October 2021

The aim of our study was to obtain similar surface properties and elemental composition to virgin implants after debridement of contaminated titanium implant surfaces covered with debris. Erbium-doped:yttrium, aluminum, and garnet (Er:YAG) laser, erbium, chromium-doped:yttrium, scandium, gallium, and garnet (Er,Cr:YSGG) laser, curette, and ultrasonic device were applied to contaminated implant surfaces. Scanning electron microscopy (SEM) images were taken, the elemental profile of the surfaces was evaluated with energy dispersive X-ray spectroscopy (EDX), and the surface roughness was analyzed with profilometry. Twenty-eight failed implants and two virgin implants as control were included in the study. The groups were designed accordingly; titanium curette group, ultrasonic scaler with polyetheretherketone (PEEK) tip, Er: YAG very short pulse laser group (100 μs, 120 mJ/pulse 10 Hz), Er: YAG short-pulse laser group (300 μs, 120 mJ/pulse, 10 Hz), Er: YAG long-pulse laser group (600 μs, 120 mJ/pulse, 10 Hz), Er, Cr: YSGG1 laser group (1 W 10 Hz), Er, Cr: YSGG2 laser group (1.5 W, 30 Hz). In each group, four failed implants were debrided for 120 s. When SEM images and EDX findings and profilometry results were evaluated together, Er: YAG long pulse and ultrasonic groups were found to be the most effective for debridement. Furthermore, the two interventions have shown the closest topography of the sandblasted, large grit, acid-etched implant surface (SLA) as seen on virgin implants.
Unveiling Semiconductor Nanostructured Based Holmium-Doped ZnO: Structural, Luminescent and Room Temperature Ferromagnetic Properties
Authors: Kabongo Guy L. , Mhlongo Gugu H. , Dhlamini Mokhotjwa S.
Published: October 2021

This research work describes the synthesis of ZnO nanostructures doped with Ho3+ ions using a conventional sol–gel synthesis method. The nanostructured produced exhibited a wurtzite hexagonal structure in both ZnO and ZnO:Ho3+ (0.25, 0.5, 0.75 mol%) samples. The change in morphology with addition of Ho3+ dopants was observed, which was assigned to Ostwald ripening effect occurring during the nanoparticles’ growth. The photoluminescence emission properties of the doped samples revealed that Ho3+ was emitting through its electronic transitions. Moreover, reduced surface defects were observed in the Holmium doped samples whose analysis was undertaken using an X-ray Photoelectron Spectroscopy (XPS) technique. Finally, enhanced room temperature ferromagnetism (RT-FM) for Ho3+-doped ZnO (0.5 mol%) samples with a peak-to-peak line width of 452 G was detected and found to be highly correlated to the UV–VIS transmittance results.
An Effective Method to Accurately Extract the Parameters of Single Diode Model of Solar Cells
Authors: Song Zhaoxu , Fang Kun , Sun Xiaofang , Liang Ying , Lin Wei , Xu Chuanzhong , Huang Gongyi , Yu Fei
Published: October 2021

A non-iterative method is presented to accurately extract the five parameters of single diode model of solar cells in this paper. This method overcomes the problems of complexity and accuracy by simplifying the calculation process. Key parts of the equation are to be adjusted dynamically so that the desired five parameters can be obtained from the I-V curve. Then, the I-V and P-V characteristic curves of solar cells are used to compare the effectiveness of this method with other methods. Furthermore, the root mean square error analysis shows that this method is more applicable than other methods. Finally, the I-V and P-V characteristics simulated by using the extracted parameters in this method are compared and discussed with the experimental data of solar cells under different conditions. In fact, this extraction process can be regarded as an effective and accurate method to estimate solar cells’ single diode model parameters.
Development of Quality Control Methods for Dispersibility and Stability of Single-Wall Carbon Nanotubes in an Aqueous Medium
Authors: Ben Basat Moran , Lachman Noa
Published: October 2021

The attractive properties of single-wall carbon nanotubes (SWCNT) such as mechanical strength and high electrical and thermal conductivity are often undercut by their agglomeration and re-agglomeration tendencies. As a result, the application of SWCNT as additives in advanced composite materials remain far from their potential, with proper dispersion being the major inhibitor. This work presents a dispersion quality control approach for water-based SWCNT dispersions (dispersed by a unique combination of physical and chemical methods), using complementary and easily scalable, characterization methods. UV-Vis spectroscopy, rheological measurements, and precipitant sheet resistance were used to understand the properties of the initial solution through processing and application. From an industrial perspective, these methods are fast and easy to measure while giving a repetitive and quick indication of dispersion quality and stability. The methods were correlated with microscopy and Raman spectroscopy to validate dispersion and SWCNT quality under various dispersing energies. The protocol was then applied to estimate the stability of SWCNT solutions, as well as the effectiveness of different surfactants in aiding dispersion. The simple, fast, and scalable combination of different characterizations provides good SWCNT dispersion and can be used as a quality control system for industrial production and usage.
Enhancing Antibodies’ Binding Capacity through Oriented Functionalization of Plasmonic Surfaces
Authors: Coluccio Maria Laura , Grillo Fabiana , Onesto Valentina , Garo Virginia , Scala Cinzia , Cuzzola Paola , Calfa Michela , Candeloro Patrizio , Gentile Francesco , Piletsky Sergey , Malara Natalia
Published: October 2021

Protein A has long been used in different research fields due to its ability to specifically recognize immunoglobulins (Ig). The protein derived from Staphylococcus aureus binds Ig through the Fc region of the antibody, showing its strongest binding in immunoglobulin G (IgG), making it the most used protein in its purification and detection. The research presented here integrates, for the first time, protein A to a silicon surface patterned with gold nanoparticles for the oriented binding of IgG. The signal detection is conveyed through a metal enhanced fluorescence (MEF) system. Orienting immunoglobulins allows the exposition of the fragment antigen-binding (Fab) region for the binding to its antigen, substantially increasing the binding capacity per antibody immobilized. Antibodies orientation is of crucial importance in many diagnostics devices, particularly when either component is in limited quantities.
Compositionally-Driven Formation Mechanism of Hierarchical Morphologies in Co-Deposited Immiscible Alloy Thin Films
Authors: Powers Max , Stewart James A. , Dingreville Rémi , Derby Benjamin K. , Misra Amit
Published: October 2021

Co-deposited, immiscible alloy systems form hierarchical microstructures under specific deposition conditions that accentuate the difference in constituent element mobility. The mechanism leading to the formation of these unique hierarchical morphologies during the deposition process is difficult to identify, since the characterization of these microstructures is typically carried out post-deposition. We employ phase-field modeling to study the evolution of microstructures during deposition combined with microscopy characterization of experimentally deposited thin films to reveal the origin of the formation mechanism of hierarchical morphologies in co-deposited, immiscible alloy thin films. Our results trace this back to the significant influence of a local compositional driving force that occurs near the surface of the growing thin film. We show that local variations in the concentration of the vapor phase near the surface, resulting in nuclei (i.e., a cluster of atoms) on the film’s surface with an inhomogeneous composition, can trigger the simultaneous evolution of multiple concentration modulations across multiple length scales, leading to hierarchical morphologies. We show that locally, the concentration must be above a certain threshold value in order to generate distinct hierarchical morphologies in a single domain.
Structure–Property Relationships in Transition Metal Dichalcogenide Bilayers under Biaxial Strains
Authors: Jiang Pingping , Boulet Pascal , Record Marie-Christine
Published: October 2021

This paper reports a Density Functional Theory (DFT) investigation of the electron density and optoelectronic properties of two-dimensional (2D) MX2 (M = Mo, W and X = S, Se, Te) subjected to biaxial strains. Upon strains ranging from −4% (compressive strain) to +4% (tensile strain), MX2 bilayers keep the same bandgap type but undergo a non-symmetrical evolution of bandgap energies and corresponding effective masses of charge carriers (m*). Despite a consistency regarding the electronic properties of Mo- and WX2 for a given X, the strain-induced bandgap shrinkage and m* lowering are strong enough to alter the strain-free sequence MTe2, MSe2, MS2, thus tailoring the photovoltaic properties, which are found to be direction dependent. Based on the quantum theory of atoms in molecules, the bond degree (BD) at the bond critical points was determined. Under strain, the X-X BD decreases linearly as X atomic number increases. However, the kinetic energy per electron G/ρ at the bond critical point is independent of strains with the lowest values for X = Te, which can be related to the highest polarizability evidenced from the dielectric properties. A cubic relationship between the absolute BD summation of M-X and X-X bonds and the static relative permittivity was observed. The dominant position of X-X bond participating in this cubic relationship in the absence of strain was substantially reinforced in the presence of strain, yielding the leading role of the X-X bond instead of the M-X one in the photovoltaic response of 2D MX2 material.
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells
Authors: Alijagic Andi , Bonura Angela , Barbero Francesco , Puntes Victor F. , Gervasi Francesco , Pinsino Annalisa
Published: October 2021

We investigated the role of the gold nanoparticles functionalized with polyvinylpyrrolidone (PVP–AuNPs) on the innate immune response against an acute infection caused by Vibrio anguillarum in an in vitro immunological nonmammalian next-generation model, the sea urchin Paracentrotus lividus. To profile the immunomodulatory function of PVP–AuNPs (0.1 μg mL−1) in sea urchin immune cells stimulated by Vibrio (10 μg mL−1) for 3 h, we focused on the baseline immunological state of the donor, and we analysed the topography, cellular metabolism, and expression of human cell surface antigens of the exposed cells, as well as the signalling leading the interaction between PVP–AuNPs and the Vibrio-stimulated cells. PVP–AuNPs are not able to silence the inflammatory signalling (TLR4/p38MAPK/NF-κB signalling) that involves the whole population of P. lividus immune cells exposed to Vibrio. However, our findings emphasise the ability of PVP–AuNPs to stimulate a subset of rare cells (defined here as Group 3) that express CD45 and CD14 antigens on their surface, which are known to be involved in immune cell maturation and macrophage activation in humans. Our evidence on how PVP–AuNPs may stimulate sea urchin immune cells represents an important starting point for planning new research work on the topic.
Investigation of Heat Transfer Enhancement in a Triple Tube Latent Heat Storage System Using Circular Fins with Inline and Staggered Arrangements
Authors: Sun Xinguo , Mohammed Hayder I. , Tiji Mohammadreza Ebrahimnataj , Mahdi Jasim M. , Majdi Hasan Sh. , Wang Zixiong , Talebizadehsardari Pouyan , Yaïci Wahiba
Published: October 2021

Inherent fluctuations in the availability of energy from renewables, particularly solar, remain a substantial impediment to their widespread deployment worldwide. Employing phase-change materials (PCMs) as media, saving energy for later consumption, offers a promising solution for overcoming the problem. However, the heat conductivities of most PCMs are limited, which severely limits the energy storage potential of these materials. This study suggests employing circular fins with staggered distribution to achieve improved thermal response rates of PCM in a vertical triple-tube heat exchanger involving two opposite flow streams of the heat-transfer fluid (HTF). Since heat diffusion is not the same at various portions of the PCM unit, different fin configurations, fin dimensions and HTF flow boundary conditions were explored using computational studies of melting in the PCM triple-tube system. Staggered configuration of fin distribution resulted in significant increases in the rates of PCM melting. The results indicate that the melting rate and heat charging rate could be increased by 37.2 and 59.1%, respectively, in the case of staggered distribution. Furthermore, the use of lengthy fins with smaller thickness in the vertical direction of the storage unit resulted in a better positive role of natural convection; thus, faster melting rates were achieved. With fin dimensions of 0.666 mm × 15 mm, the melting rate was found to be increased by 23.6%, when compared to the base case of 2 mm × 5 mm. Finally, it was confirmed that the values of the Reynolds number and inlet temperatures of the HTF had a significant impact on melting time savings when circular fins of staggered distribution were included.
Facile Fabrication of Three-Dimensional Fusiform-Like α-Fe2O3 for Enhanced Photocatalytic Performance
Authors: Li Moyan , Liu Hongjin , Pang Shaozhi , Yan Pengwei , Liu Mingyang , Ding Minghui , Zhang Bin
Published: October 2021

α-Fe2O3 fusiform nanorods were prepared by a simple hydrothermal method employing the mixture of FeCl3·6H2O and urea as raw materials. The samples were examined by X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and UV–vis diffuse reflectance spectra (UV–DRS). Its visible-light photocatalytic performances were evaluated by photocatalytic decolorization methylene blue (MB) in visible light irradiation. It was found that pure phase α-Fe2O3 nanorods with a length of about 125 nm and a diameter of 50 nm were successfully synthesized. The photocatalytic decolorization of MB results indicated that α-Fe2O3 nanorods showed higher photocatalytic activity than that of commercial Fe2O3 nanoparticles—these are attributed to its unique three-dimensional structure and lower electron-hole recombination rate.
Nanobeams with Internal Discontinuities: A Local/Nonlocal Approach
Authors: Scorza Daniela , Vantadori Sabrina , Luciano Raimondo
Published: October 2021

The aim of the present work is to extend the two-phase local/nonlocal stress-driven integral model (SDM) to the case of nanobeams with internal discontinuities: as a matter of fact, the original formulation avoids the presence of any discontinuities. Consequently, here, for the first time, the problem of an internal discontinuity is addressed by using a convex combination of both local and nonlocal phases of the model by introducing a mixture parameter. The novel formulation here proposed was validated by considering six case studies involving different uncracked nanobeams by varying the constrains and the loading configurations, and the effect of nonlocality on the displacement field is discussed. Moreover, a centrally-cracked nanobeam, subjected to concentrated forces at the crack half-length, was studied. The size-dependent Mode I fracture behaviour of the cracked nanobeam was analysed in terms of crack opening displacement, energy release rate, and stress intensity factor, showing the strong dependency of the above fracture properties on both dimensionless characteristic length and mixture parameter values.
A Novel Branched Al2O3/Silicon Rubber Composite with Improved Thermal Conductivity and Excellent Electrical Insulation Performance
Authors: Ouyang Yuge , Li Xiaofei , Tian Huafeng , Bai Liuyang , Yuan Fangli
Published: October 2021

In this paper, we report a thermal conductive polymer composite that consists of silicone rubber (SR) and branched Al2O3 (B-Al2O3). Owing to the unique two-dimensional branched structure, B-Al2O3 particles form a continuous three-dimensional network structure by overlapping each other in the matrix, serving as a continuous heat conductive pathway. As a result, the polymer composite with a 70 wt% filler achieves a maximum thermal conductivity of 1.242 Wm−1 K−1, which is equivalent to a significant enhancement of 521% compared to that of a pure matrix. In addition, the composite maintains a high volume resistivity of 7.94 × 1014 Ω·cm with the loading of 70 wt%, indicating that it meets the requirements in the field of electrical insulation. Moreover, B-Al2O3 fillers are well dispersed (no large agglomerates) and form a strong interfacial adhesion with the matrix. Therefore, the thermal decomposition temperature, residual mass, tensile strength, modulus and modulus of toughness of composites are significantly improved simultaneously. This strategy provides new insights for the design of high-performance polymer composites with potential application in advanced thermal management in modern electronics.
Ligand Effects on Intramolecular Configuration, Intermolecular Packing, and Optical Properties of Metal Nanoclusters
Authors: Wu Sainan , Wei Xiao , Li Hao , Shen Honglei , Han Jiaojiao , Kang Xi , Zhu Manzhou
Published: October 2021

Surface modification has served as an efficient approach to dictate nanocluster structures and properties. In this work, based on an Ag22 nanocluster template, the effects of surface modification on intracluster constructions and intercluster packing modes, as well as the properties of nanoclusters or cluster-based crystallographic assemblies have been investigated. On the molecular level, the Ag22 nanocluster with larger surface steric hindrance was inclined to absorb more small-steric chlorine but less bulky thiol ligands on its surface. On the supramolecular level, the regulation of intramolecular and intermolecular interactions in nanocluster crystallographic assemblies rendered them CIEE (crystallization-induced emission enhancement)-active or -inactive nanomaterials. This study has some innovation in the molecular and intramolecular tailoring of metal nanoclusters, which is significant for the preparation of new cluster-based nanomaterials with customized structures and enhanced performances.
The Bio-Persistence of Reversible Inflammatory, Histological Changes and Metabolic Profile Alterations in Rat Livers after Silver/Gold Nanorod Administration
Authors: Liu Ying , Wen Hairuo , Wu Xiaochun , Wu Meiyu , Liu Lin , Wang Jiahui , Huo Guitao , Lyu Jianjun , Xie Liming , Dan Mo
Published: October 2021

As a widely applied nanomaterial, silver nanomaterials (AgNMs) have increased public concern about their potential adverse biological effects. However, there are few related researches on the long-term toxicity, especially on the reversibility of AgNMs in vivo. In the current study, this issue was tackled by exploring liver damage after an intravenous injection of silver nanorods with golden cores (Au@AgNRs) and its potential recovery in a relatively long term (8 w). After the administration of Au@AgNRs into rats, Ag was found to be rapidly cleared from blood within 10 min and mainly accumulated in liver as well as spleen until 8 w. All detected parameters almost displayed a two-stage response to Au@AgNRs administration, including biological markers, histological changes and metabolic variations. For the short-term (2 w) responses, some toxicological parameters (hematological changes, cytokines, liver damages etc.) significantly changed compared to control and AuNRs group. However, after a 6-week recovery, all abovementioned changes mostly returned to the normal levels in the Au@AgNRs group. These indicated that after a lengthy period, acute bioeffects elicited by AgNMs could be followed by the adaptive recovery, which will provide a novel and valuable toxicity mechanism of AgNMs for potential biomedical applications of AgNMs.
A Triboelectric Nanogenerator Based on Sodium Chloride Powder for Self-Powered Humidity Sensor
Authors: Ding Zhuyu , Zou Ming , Yao Peng , Zhu Zhiyuan , Fan Li
Published: October 2021

Recently, the research of distributed sensor networks based on triboelectric technology has attracted extensive attention. Here, we reported a new triboelectric nanogenerator based on sodium chloride powder (S-TENG) to obtain mechanical energy. The polytetrafluoroethylene (PTFE) film and sodium chloride powder layer serve as the triboelectric pair. After testing and calculation, the internal resistance of S-TENG is 30 MΩ, and the output power of S-TENG (size: 6 cm × 6 cm) can arrive at the maximum value (about 403.3 µW). Furthermore, the S-TENG can achieve the open circuit voltage (Voc) of 198 V and short-circuit current (Isc) of 6.66 µA, respectively. Moreover, owing to the moisture absorption of sodium chloride powder, the S-TENG device also has the function of the humidity sensor. This work proposed a functional TENG device, and it can promote the advancement of self-powered sensors based on the TENG devices.
Valorization of Brewery Wastes for the Synthesis of Silver Nanocomposites Containing Orthophosphate
Authors: Sudagar Alcina Johnson , Rangam Neha Venkatesh , Ruszczak Artur , Borowicz Paweł , Tóth József , Kövér László , Michałowska Dorota , Roszko Marek Ł. , Noworyta Krzysztof R. , Lesiak Beata
Published: October 2021

Brewery wastes from stage 5 (Wort precipitate: BW5) and stage 7 (Brewer’s spent yeast: BW7) were valorized for the synthesis of silver phosphate nanocomposites. Nanoparticles were synthesized by converting silver salt in the presence of brewery wastes at different temperatures (25, 50, and 80 °C) and times (10, 30, and 120 min). Unexpectedly, BW7 yielded Ag3PO4 nanoparticles with minor contents of AgCl and Ag metal (Agmet). Contrastingly, BW5 produced AgCl nanoparticles with minor amounts of Ag3PO4 and Agmet. Nanocomposites with different component ratios were obtained by simply varying the synthesis temperature and time. The morphology of the nanocomposites contained ball-like structures representative of Ag3PO4 and stacked layers and fused particles representing AgCl and Agmet. The capping on the nanoparticles contained organic groups from the brewery by-products, and the surface overlayer had a rich chemical composition. The organic overlayers on BW7 nanocomposites were thinner than those on BW5 nanocomposites. Notably, the nanocomposites exhibited high antibacterial activity against Escherichia coli ATCC 25922. The antibacterial activity was higher for BW7 nanocomposites due to a larger silver phosphate content in the composition and a thin organic overlayer. The growth of Agmet in the structure adversely affected the antimicrobial property of the nanocomposites.
Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative
Authors: Alfei Silvana , Brullo Chiara , Caviglia Debora , Zuccari Guendalina
Published: October 2021

2-(4-Bromo-3,5-diphenyl-pyrazol-1-yl)-ethanol (BBB4) was synthetized and successfully evaluated concerning numerous biological activities, except for antimicrobial and cytotoxic effects. Due to the antimicrobial effects possessed by pyrazole nucleus, which have been widely reported, and the worldwide need for new antimicrobial agents, we thought it would be interesting to test BBB4 and to evaluate its possible antibacterial effects. Nevertheless, since it is water-insoluble, the future clinical application of BBB4 will remain utopic unless water-soluble BBB4 formulations are developed. To this end, before implementing biological evaluations, BBB4 was herein re-synthetized and characterized, and a new water-soluble BBB4-based nano-formulation was developed by its physical entrapment in a biodegradable non-cytotoxic cationic dendrimer (G4K), without recovering harmful solvents as DMSO or surfactants. The obtained BBB4 nanoparticles (BBB4-G4K NPs) showed good drug loading (DL%), satisfying encapsulation efficiency (EE%), and a biphasic quantitative release profile governed by first-order kinetics after 24 h. Additionally, BBB4-G4K was characterized by ATR-FTIR spectroscopy, NMR, SEM, dynamic light scattering analysis (DLS), and potentiometric titration experiments. While, before the nanotechnological manipulation, BBB4 was completely water-insoluble, in the form of BBB4-G4K NPs, its water-solubility resulted in being 105-fold higher than that of the pristine form, thus establishing the feasibility of its clinical application.
Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin
Authors: Vasey Clayton , McBride Jennifer , Penta Kayla
Published: October 2021

Sleep is an essential component of overall human health but is so tightly regulated that when disrupted can cause or worsen certain ailments. An important part of this process is the presence of the well-known hormone, melatonin. This compound assists in the governing of sleep and circadian rhythms. Previous studies have postulated that dysregulation of melatonin rhythms is the driving force behind sleep and circadian disorders. A computer-aided search spanning the years of 2015–2020 using the search terms melatonin, circadian rhythm, disorder yielded 52 full text articles that were analyzed. We explored the mechanisms behind melatonin dysregulation and how it affects various disorders. Additionally, we examined associated therapeutic treatments including bright light therapy (BLT) and exogenous forms of melatonin. We found that over the past 5 years, melatonin has not been widely investigated in clinical studies thus there remains large gaps in its potential utilization as a therapy.
Exposure to Normobaric Hypoxia Combined with a Mixed Diet Contributes to Improvement in Lipid Profile in Trained Cyclists
Authors: Płoszczyca Kamila , Czuba Miłosz , Langfort Józef , Baranowski Marcin
Published: October 2021

This study aimed to analyze the effects of live high-train low method (LH-TL) and intermittent hypoxic training (IHT) with a controlled mixed diet on lipid profile in cyclists. Thirty trained male cyclists at a national level with at least six years of training experience participated in the study. The LH-TL group was exposed to hypoxia (FiO2 = 16.5%) for 11–12 h a day and trained under normoxia for 3 weeks. In the IHT group, participants followed the IHT routine three times a week under hypoxia (FiO2 = 16.5%) at lactate threshold intensity. The control group (N) lived and trained under normoxia. The results showed that the 3-week LH-TL method significantly improved all lipid profile variables. The LH-TL group showed a significant increase in HDL-C by 9.0% and a decrease in total cholesterol (TC) by 9.2%, LDL-C by 18.2%, and triglycerides (TG) by 27.6%. There were no significant changes in lipid profiles in the IHT and N groups. ∆TG and ∆TC were significantly higher in the LH-TL group compared to the N group. In conclusion, hypoxic conditions combined with a mixed diet can induce beneficial changes in lipid profile even in highly trained athletes. The effectiveness of the hypoxic stimulus is closely related to the hypoxic training method.
Iodine Intake from Food and Iodized Salt as Related to Dietary Salt Consumption in the Italian Adult General Population
Authors: Iacone Roberto , Iaccarino Idelson Paola , Russo Ornella , Donfrancesco Chiara , Krogh Vittorio , Sieri Sabina , Macchia Paolo Emidio , Formisano Pietro , Lo Noce Cinzia , Palmieri Luigi , Galeone Daniela , Rendina Domenico , Galletti Ferruccio , Di Lenarda Andrea , Giampaoli Simona , Strazzullo Pasquale ,   on behalf of the MINISAL-GIRCSI Study Group
Published: October 2021

Since the Italian iodoprophylaxis strategy is based on the use of iodized salt, we assessed the relationship between dietary salt consumption and iodine intake in the Italian adult population. We estimated the relative contribution given by the use of iodized salt and by the iodine introduced by foods to the total iodine intake. The study population included 2219 adults aged 25–79 years (1138 men and 1081 women) from all Italian regions, participating to the Osservatorio Epidemiologico Cardiovascolare/Health Examination Survey 2008–2012 (OEC/HES), and examined for sodium and iodine intake in the framework of the MINISAL-GIRCSI Programme. Dietary sodium and total iodine intake were assessed by the measurement of 24 h urinary excretion, while the EPIC questionnaire was used to evaluate the iodine intake from food. Sodium and iodine intake were significantly and directly associated, upon accounting for age, sex, and BMI (Spearman rho = 0.298; p < 0.001). The iodine intake increased gradually across quintiles of salt consumption in both men and women (p < 0.001). The European Food Safety Authority (EFSA) adequacy level for iodine intake was met by men, but not women, only in the highest quintile of salt consumption. We estimated that approximately 57% of the iodine intake is derived from food and 43% from salt. Iodized salt contributed 24% of the total salt intake, including both discretionary and non-discretionary salt consumption. In conclusion, in this random sample of the Italian general adult population examined in 2008–2012, the total iodine intake secured by iodized salt and the iodine provision by food was insufficient to meet the EFSA adequate iodine intake.
Dietary Barley Leaf Mitigates Tumorigenesis in Experimental Colitis-Associated Colorectal Cancer
Authors: Li Daotong , Feng Yu , Tian Meiling , Hu Xiaosong , Zheng Ruimao , Chen Fang
Published: October 2021

Dietary barley (Hordeum vulgare L.) leaf (BL) is a popular functional food known to have potential health benefits; however, the effect of BL in colorectal cancer prevention has not been examined. Here, we examined the role of BL on the prevention of colorectal carcinogenesis and defined the mechanism involved. BL supplementation could protect against weight loss, mitigate tumor formation, and diminish histologic damage in mice treated with azoxymethane (AOM) and dextran sulfate sodium (DSS). Moreover, BL suppressed colonic expression of inflammatory enzymes, while improving the mucosal barrier dysfunctions. The elevated levels of cell proliferation markers and the increased expression of genes involved in β-catenin signaling were also reduced by BL. In addition, analyses of microbiota revealed that BL prevented AOM/DSS-induced gut microbiota dysbiosis by promoting the enrichment of Bifidobacterium. Overall, these data suggest that BL is a promising dietary agent for preventing colitis-associated colorectal cancer.
Trajectories of Energy Intake Distribution and Risk of Dyslipidemia: Findings from the China Health and Nutrition Survey (1991–2018)
Authors: Song Xiaoyun , Wang Huijun , Su Chang , Wang Zhihong , Du Wenwen , Huang Feifei , Zhang Jiguo , Jia Xiaofang , Jiang Hongru , Ouyang Yifei , Li Li , Bai Jing , Zhang Xiaofan , Ding Gangqiang , Zhang Bing
Published: October 2021

Few studies have examined the secular trend of energy intake distribution. This study aims to describe trajectories of energy intake distribution and determine their association with dyslipidemia risk. Data of 2843 adult participants from the China Health and Nutrition Survey (CHNS) were analyzed. Trajectory groups of energy intake distribution were identified by multi-trajectory model over 27 years. Multilevel mixed-effects modified Poisson regression with robust estimation of variance was used to calculate risk ratio for incident dyslipidemia in a 9-year follow-up. Four trajectory groups were identified: “Energy evenly distributed group” (Group 1), “Lunch and dinner energy dominant group” (Group 2), “Dinner energy dominant group” (Group 3), “breakfast and dinner energy dominant group” (Group 4). Compared with Group 1, Group 3 was associated with higher risk of dyslipidemia (RR = 1.48, 95% CI = 1.26, 1.75), hypercholesterolemia (RR = 1.96, 95% CI = 1.37, 2.81) and high low-density lipoproteins cholesterols (LDL-C) (RR = 2.41, 95% CI = 1.82, 3.20). A U-shape was observed between cumulative average proportion of dinner energy and dyslipidemia risk (p for non-linear = 0.01), with stronger relationship at 40% and above. Energy intake distribution characterized by higher proportion of dinner energy, especially over 40% was associated with higher dyslipidemia risk in Chinese adults.