bluuebunny/crossref_metadata_2025 huggingface dataset:
The 2016 RANZCP Guidelines for the Management of Schizophrenia and Related Disorders – what’s next?
Authors: Jablensky Assen , Castle David J , Dark Frances , Humberstone Verity , Killackey Eoin , Kulkarni Jayashri , McGorry Patrick , Morgan Vera A , Nielssen Olav , Tran Nga , Galletly Cherrie
Published: September 2017

Objectives:

The recently published RANZCP guidelines for schizophrenia and related disorders reviewed recent scientific evidence, and, where lacking, referred to clinical expertise to supply a template for raising the standard of care. This paper builds on the guidelines and recommends how they might be used to improve outcomes.

Methods:

The guidelines call for evidence-based mental health policies, inclusive of mobilising affected families, communities and the public in support of policies that ensure better care and protect the wellbeing of people with severe mental disorders. The process of preparing the guidelines highlighted the limits of our scientific understanding of schizophrenia and shortcomings in the care currently provided.

Results:

Writing the guidelines evinced the need for a culture of measuring outcomes and response to treatment, and harnessing such data to monitoring and optimising patient care.

Conclusions:

We recommend creation of a national case cohort for mental health research involving a collaborative network of clinical research centres, using the guidelines and generating scientific evidence for translation into clinical practice protocols that enable personalised treatment plans for patients and criteria for the performance of clinical services.
Psychiatric advance directives in Australian mental-health legislation
Authors: Ouliaris Calina , Kealy-Bateman Warren
Published: September 2017

Objective:

Following the recent widespread reform of mental-health legislation in Australia, psychiatric advance directives (PADs) have now been incorporated in four jurisdictions. We contextualise the potential role for PADs within the Australian legal framework and note their varying introduction across jurisdictions, with a focus on progressive legislation in the Australian Capital Territory (ACT).

Conclusion:

The formal recognition of PADs effectively shifts the trajectory of mental-health law towards a stronger recognition of consumer autonomy, albeit to varying degrees across jurisdictions. The most inspiring of these changes may be seen in the ACT Act, where an innovative framing of PAD provisions creates a safe space for clinicians and patients to engage, build therapeutic alliances and develop appropriate frameworks for further change.
Pushing Interdisciplinary in the Study of Groups and Teams
Authors: Keyton Joann , Heylen Dirk K. J.
Published: September 2017

As the concluding article of the special issue from the Lorentz, Netherlands workshop, “New Frontiers in Analyzing Dynamic Group Interactions: Bridging Social and Computer Science,” the authors describe ways in which computer scientists and social scientists can integrate their work to pursue interdisciplinary that can satisfy the research agendas of both sets of scholars.
Race and the Meso-Level Sources of Domination
Authors: Banerjee Kiran , Singer Abraham
Published: September 2017

This paper contributes to recent debates over the place of race in liberal theory, and the work of John Rawls in particular. Controversy has centered on whether Rawls’s broader philosophical approach is capable of addressing racial injustice, and if not, precisely why the Rawlsian framework remains disconcertingly blind to such issues. Pace scholars who focus on Rawls’s emphasis on “ideal theory,” and whether that precludes his engagement with racial domination, we show that Rawls’s inability to account for, or address, racial injustice lies in his limited understanding of the kinds of “associations” or institutions that condition and perpetuate racial oppression. As studies in race and American Political Development have shown, nonstatutory institutions such as political parties, unions, and universities were key to the development and maintenance of racial hierarchical order. Fully understanding the role of these institutions in perpetuating racial injustice allows us to see that the limitations of Rawls are not his ideal theory, per se, but his preoccupation with the “basic structure” of society, which rendered such institutions outside his analysis. We conclude by drawing on thinkers in the Afro-Modern tradition who help us conceptualize how such institutions are complicit in, and can be weaponized against, racial domination.
The Association of Aging With Von Willebrand Factor Levels and Bleeding Risk in Type 1 Von Willebrand Disease
Authors: Seaman Craig D. , Ragni Margaret V.
Published: September 2017

Little is known about aging in von Willebrand disease (VWD). It is uncertain whether VWD patients experience an age-related increase in von Willebrand factor (VWF) levels, and if so, it is unknown whether normalization of VWF levels with aging ameliorates bleeding risk. We aimed to determine the association of age with VWF levels and bleeding risk in patients with type 1 VWD. This is a retrospective chart review of patients with type 1 VWD presenting to the Hemophilia Clinic of Western Pennsylvania for regularly scheduled clinic visits. Data collected included VWF antigen level and condensed molecular and clinical markers for the diagnosis and management of Type 1 (MCMDM-1) VWD bleeding assessment tool (BAT) bleeding score based on bleeding symptoms during the previous 3 years. Thirty-nine patients participated in the study, and 32 were female. The average age of participants was 41.8 ± 18.0 years. The mean VWF antigen level was 0.83 ± 0.37 IU/mL, and the mean bleeding score was 2.51 ± 2.90. The bleeding score was inversely associated with age, β = −0.080 (SE = 0.023), P < .01. There was a nonsignificant association between VWF antigen levels and age. To our knowledge, this is the first report showing an association between aging and decreased bleeding symptoms in patients with type 1 VWD. Determining whether or not bleeding risk is reduced in older patients with type 1 VWD is essential for optimal clinical management. Moreover, VWF concentrate is costly, and unwarranted use represents a significant waste of health-care dollars. These findings warrant further investigation.
Behaviour of steel–concrete–steel sandwich composite beams with lacing subjected to reversed cyclic loads
Authors: Anandavalli N , Lakshmanan N , Rajasankar J , Knight GM Samuel
Published: September 2017

Steel–concrete–steel (SCS) sandwich composite system consists of steel plates covering both sides of the concrete core and connected by mechanical means such as shear connectors. In conventional steel–concrete–steel system, shear connectors are welded to the steel cover plates. Laced steel–concrete composite (LSCC) system is a new form of steel–concrete–steel, proposed earlier by the authors. In LSCC system, steel cover plates are connected in a novel way using lacings and cross rods and hence is devoid of welding. Proposed sandwich composite system is being evaluated systematically for its structural behaviour under various modes of loading for use in special structures under severe loading such as blast loading. Damage under cyclic loading and energy absorption are extremely important, which are highlighted in this paper. An experimental investigation on the cyclic response behaviour of two LSCC beams is carried out. Angle of lacing is the parameter that is varied between the two beams. Both the beams are found to exhibit similar behaviour on most of the aspects. The envelope of hysteretic response indicates mild softening behaviour after reaching peak value. Maximum load resisted under both sagging and hogging moment conditions is found to be nearly equal, thus making the LSCC system suitable for situations where reversal of loads are encountered. Dissipated energy is observed to be nearly the same for the load applied in the upward as well as in the downward direction. Analytical prediction on energy absorption capacity is carried out by adopting a hysteretic model with strength deterioration. Cyclic ductility factor is evaluated to be about 20 for LSCC beams, while support rotation is calculated to be about 8° and 10° for beams with 45° and 60° angles of lacing, respectively. Spalling of concrete is prevented in LSCC beams by the steel cover plates.
Don’t Let Them Fool You
Authors: Lahav Eyal , Shavit Tal , Benzion Uri
Published: September 2017

In the last 20 years, adolescents have gradually become very important clients for the banking industry. The current study investigates, using data collected in a survey, whether adolescents offered two options for investing in a saving certificate choose the financially preferable one and whether this choice is related to their time preference, after controlling for gender and bank account ownership. The participants were 270 adolescents from public high schools in Israel. The findings indicate that approximately 40 per cent made the inferior financial decision. However, those with a bank account were less likely to decide poorly, possibly indicating that having an account reduces financial illiteracy. Moreover, selecting the financially inferior choice correlates with a higher subjective discount rate (higher present-orientation). A gender effect is also found; girls have higher subjective discount rates, and this effect is stronger for girls with a bank account. Policy implications regarding financial education programmes are discussed.
Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer
Authors: Yoshizawa Tadashi , Ishido Keinosuke , Saito Kensuke , Haga Toshihiro , Seino Hiroko , Wu Yunyan , Morohashi Satoko , Hakamada Kenichi , Kijima Hiroshi
Published: September 2017

Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy.
Critical–reflexive–political: Dismantling the reproduction of dominance in organisational learning processes
Authors: Collien Isabel
Published: September 2017

This article identifies and addresses the need for a stronger engagement of power-sensitive organisational learning research with societal power relations and related issues of persisting dominance. Based on Bourdieu’s theory of practice, I lay a theoretical foundation to explain the reproduction of dominance structures in micro-level learning processes. Departing from this foundation, I define a conceptual triad as necessary elements to identify and dismantle the subtle workings of group dominance in organisational learning processes. Each of the triad’s elements – being critical, being reflexive and being political – expands currently underexposed issues in organisational learning research regarding understandings of context, reflexivity and practice-oriented responsibility.
Individual differences in language experience and bilingual autobiographical memory
Authors: Cox Jessica G , Zlupko Gian M
Published: September 2017

Purpose:

This study investigates factors underlying recall of autobiographical memories by considering multiple dimensions of bilingualism (e.g., proficiency, frequency of use), rather than treating it as a monolithic construct. Specifically, we investigated what factors predicted recall of memories in which the language of encoding did not match the language of the task, a recall phenomenon that, by definition, only occurs with bilingual individuals.

Design:

Spanish/English heritage bilinguals viewed cue words in English to prompt recall of autobiographical memories and narrated those memories out loud, then stated in what language the original events had occurred.

Data and Analysis:

The dataset consists of 18 narratives from each of 37 participants. Mixed-effects models determined which aspects of the heritage bilingual experience predicted recall of memories in which language of encoding and task did not match.

Findings/Conclusions:

More frequent use of Spanish and having been born outside the USA predicted more Spanish-language memories retrieved in an English-language task. Interestingly, Spanish proficiency, English age of acquisition, and the type of cue word (object, action, or emotion) did not have effects. Results are discussed in terms of language use and language skill, as well as the importance of considering the specific nature of the bilingual experience.

Originality:

This study follows calls to take a multifaceted approach to empirical studies of bilingualism and is innovative in its use of mixed-level models to do so.

Significance/Implications:

By analyzing multiple factors that contribute to bilingual experiences, we are able to better state what exactly it is about bilinguals that affects – or does not affect – cognition, including autobiographical memory. The results will allow us to be more precise in advising policy and practice, such as in bilingual education.
Free vibration analysis of a shape memory alloy beam with pseudoelastic behavior
Authors: Razavilar Reza , Fathi Alireza , Dardel Morteza , Arghavani Hadi Jamal
Published: September 2017

The present contribution deals with developing a semi-analytical analysis for studying the free vibration of a shape memory alloy beam with pseudoelastic behavior. The equations of motion are derived using the Hamilton principle and the Euler–Bernoulli theory. Then mathematical processes of non-dimensionalization and numerical integration are performed and finally the obtained partial differential equations are solved using the Galerkin method. A three-dimensional phenomenological model for shape memory alloy, which has the capability of identifying the martensite phase transformation, saturated phase transformation, pseudoelasticity and the shape memory effect, is utilized for modeling the shape memory alloy. According to the hysteresis behavior of the shape memory alloy, the energy dissipation characteristic is clearly observed in the early stages of the free vibration. Stress and strain analysis is employed to specify the effect of phase transformation in each layer along the beam. The property of shape memory alloy beam demonstrates its great potential for using in damping applications.
Towards a digital architecture of reflexive ethnographic data
Authors: Weber Florence
Published: September 2017

Why and how should we auto-archive reflexive ethnographic data? Ethnography is based on a graphic method of written and visual notations, traditionally using notebooks. Reflexive ethnographers have been trained to separate their notebooks in two parts: the concise fieldwork log recording dates, places and events, and the research log putting down emotions and theoretical considerations. In addition, they collect varied documents coming from the field. The whole set makes the scientific value of ethnographic analyses, along with peer value process. My team develops a digital data base where “cases” within “settings” are defined by research objects and questions, and where documents are classified in three levels of confidentiality according to personal data protection and copyrights.
What role does the ‘parent-effect’ play in child centered research? The case of photo-interviews of children’s home reading practices
Authors: Hillier Cathlene , Aurini Janice
Published: September 2017

Drawing on a photo-interview study of home reading practices with 35 children (ages 5–8) we examine how the ‘parent-effect’ influences research with young children. Not surprisingly, we find that parents influence reading practices and access to literacy resources. However, it is also clear that children’s reliance on parents affects data collection. Children who have more help from parents produce better photographs and a clearer narrative about home reading practices, but parents’ use of impression management influence the images that children produce and sometimes the photo-interview that follows. Rather than compromising children’s agency or the purity of the data, we argue that the parent-effect can be used an indicator of cultural norms about parenting; it can shed light into the dynamics of the parent-child relationships; and it can illuminate the degree to which children exert ‘child capital’ over home reading practices and the social construction of family life.
Scholarly or socially relevant? An examination of European academic associations
Authors: Fumasoli Tatiana , Seeber Marco
Published: September 2017

The academic profession has been long recognized as a pivotal source of belief and identity alongside the discipline and the institution of belonging. However, the ways in which academics as a professional group organize themselves towards common objectives that possibly transcend systems, institutions and disciplines, has not been explored so far. Therefore, the goal of this article is investigate how academics organize themselves in the pursuit of their professional, scientific and scholarly interests outside the university setting and across national higher education systems. We address this question by studying European academic associations. Drawing from World Polity Theory, studies on Professions and Professionalism, as well as on Interest Groups, we derive expectations as to the growth in number of academic associations and their aims. Based on the analysis of 324 associations, our findings show that assuming that the founding of academic associations is related primarily to the emergence or presence of international organizations needs to be revisited, as foundations appear to be affected by other contingent events as well. As to their aims, there is more variety than usually posited and five types of academic associations can be identified. We discuss the implications of on-going European integration in higher education and research from theory and policy perspectives.
A Recently Discovered Bell: Artifact, Metaphor, Secrets, and Identity in an Italian American Family
Authors: Reale Michelle
Published: September 2017

Secrets in families are often toxic, leading to a sense of bewilderment at one’s own identity. Within the context of family origins, the discovery of seemingly simple and ordinary artifacts, far from being revelatory, can further obscure meaning and understanding of the person to whom it belonged. The effect of secrets can reverberate for generations affecting who we are, where we come from, and who we have the potential to be.
An Ultralow-Dose 1-Day Protocol With Activities Lower Than 20 MBq for the Detection of Sentinel Lymph Nodes in Breast Cancer—Experiences After 150 Cases
Authors: Kolberg Hans-Christian , Afsah Shabnam , Kuehn Thorsten , Winzer Ute , Akpolat-Basci Leyla , Stephanou Miltiades , Wetzig Sarah , Hoffmann Oliver , Liedtke Cornelia
Published: September 2017

Introduction:

Common protocols for the detection of sentinel lymph nodes in early breast cancer often include the injection of the tracer 1 day before surgery. In order to detect enough activity on the day of surgery, the applied activity in many protocols is as high as several hundred MBq. So far, very few protocols with an activity below 20 MBq have been reported. We developed an ultralow-dose 1-day protocol with a mean activity lower than 20 MBq in order to reduce radiation exposure for patients and staff. Here, we are presenting our experiences in 150 consecutive cases.

Materials and Methods:

A total of 150 patients with clinically and sonographically negative axilla and no multicentricity underwent a sentinel lymph node biopsy using an ultralow-dose protocol performed on the day of surgery. No patient received systemic therapy prior to sentinel node biopsy. After peritumoral injection of the tracer Technetium-99m, a lymphoscintigraphy was performed in all cases. Seven minutes before the first cut, we injected 5 mL of blue dye in the region of the areola.

Results:

In 148 (98.7%) of 150 patients, at least 1 sentinel lymph node could be identified by lymphoscintigraphy; the detection rate during surgery with combined tracers Technetium-99m and blue dye was 100%. The mean applied activity was 17.8 MBq (9-20). A mean number of 1.3 (0-5) sentinel lymph nodes were identified by lymphoscintigraphy and a mean number of 1.8 (1-5) sentinel lymph nodes were removed during sentinel lymph node biopsy.

Conclusion:

Ultralow-dose 1-day protocols with an activity lower than 20 MBq are a safe alternative to 1-day or 2-day protocols with significantly higher radiation doses in primary surgery for early breast cancer. Using Technetium-99m and blue dye in a dual tracer approach, detection rates of 100% are possible in clinical routine in order to reduce radiation exposure for patients and staff.
The Importance of Replication in Measurement Research: Using Curriculum-Based Measures With Postsecondary Students With Developmental Disabilities
Authors: Hosp John L. , Ford Jeremy W. , Huddle Sally M. , Hensley Kiersten K.
Published: September 2017

Replication is a foundation of the development of a knowledge base in an evidence-based field such as education. This study includes two direct replications of Hosp, Hensley, Huddle, and Ford which found evidence of criterion-related validity of curriculum-based measurement (CBM) for reading and mathematics with postsecondary students with developmental disabilities (DD). Participants included two cohorts of postsecondary students with DD enrolled in a 2-year certificate program at a large Midwestern university ( n = 24 and 21). Using the same standardized procedures as Hosp et al., participants were administered CBMs for Oral Passage Reading (OPR), Maze, Math Computation, and Math Concepts and Applications. Descriptive statistics and bivariate correlations between CBMs and the content-appropriate Woodcock–Johnson Tests of Achievement–Third Edition were calculated. No significant differences in criterion-related validity coefficients between cohorts were found but differences between the correlations for Math Computation and Math Concepts and Applications identified in Hosp et al. were not found in either replication cohort.
Analyzing State Autism Private Insurance Mandates for Allied Health Services: A Pilot Study
Authors: Douglas Megan D. , Benevides Teal W. , Carretta Henry
Published: September 2017

Due to the prevalence, severity, and costs associated with autism spectrum disorders (ASDs), it has become a public health issue. In response, state governments have adopted ASD-specific private insurance mandates requiring coverage of ASD screening, diagnosis, and treatment. Despite rapid uptake of these laws, differences exist in the type and levels of coverage, especially for allied health services including occupational therapy. We piloted a structured legal research methodology to code ASD insurance mandates that impact allied health service provisions. State private insurance mandates were obtained from WestlawNext. A coding methodology was piloted on 14 states and included variables for age and service limits, treatments covered, and medical necessity. Coding methods were feasible and highly reliable among raters. Ten of 12 states had a coverage mandate, many with specific provisions for allied health providers. A full analysis of all 50 states is warranted to identify provisions affecting allied health providers serving individuals with ASD.
Commodification and marketisation of genetic testing through online direct-to-consumer platforms in Hong Kong
Authors: Zayts Olga , Luo Zhengpeng
Published: September 2017

In this article we examine commodification and marketisation of genetic testing by companies offering direct-to-consumer (DTC) genetic testing to the general public through online platforms in Hong Kong. Recently, offers of genetic testing have expanded from scientific and clinical genetic settings to general medicine (e.g. in hereditary cancer) and non-medical domains (e.g. aptitude tests). The wider availability of tests, however, has raised concerns about the currently available scientifically proven utility of these tests. Using theme-oriented discourse analysis, we analyse the specific discursive modalities through which the DTC companies in Hong Kong make inflated claims about the value of genetic tests to pursue their marketing agenda. We show that in this way the companies are selling ‘more’ than specific products to consumers: they are selling ‘hope’ and ‘increased autonomy’, that is, an opportunity to buy commodities online that promise consumers control of their health and wellbeing.
The Long and Winding Road Toward Personalized Glycemic Control in the Critically Ill
Authors: Krinsley James Stephen
Published: September 2017

Hyperglycemia is very common in critically ill patients and interventional studies of intensive insulin therapy with the goal of returning ICU glycemia to normal levels have demonstrated mixed results. A large body of literature has demonstrated that diabetes, per se, is not independently associated with increased risk of mortality in this population and that the relationship of glucose metrics to mortality is different for patients with and without diabetes. Moreover, these relationships are confounded by preadmission glycemia; in this regard, patients with diabetes and good preadmission glucose control, as reflected by HbA1c levels obtained at the time of ICU admission, are similar to patients without diabetes. These data point the way toward an era when blood glucose targets in the ICU will be “personalized,” based on assessment of preadmission glycemia.
Mobile sourcing: A case study of journalistic norms and usage of chat apps
Authors: Belair-Gagnon Valerie , Agur Colin , Frisch Nicholas
Published: September 2017

Since 2011, mobile chat apps have gained significant popularity worldwide and the leading chat apps have surpassed social networking sites in user numbers. These apps have become the hosts for everyday communication among a wide variety of users and, thanks to the functionalities of certain apps, have taken on new significance in reporting. Especially in Hong Kong (a high-income, high-tech society in which smartphones are in widespread use) and mainland China (an emerging market with more than 1 billion mobile phone users), journalists have turned to these apps to complement face-to-face interactions to gather news. Drawing on a case study building on in-depth interviews with foreign correspondents based in China and Hong Kong, this article discusses how journalists use chat apps and establish trust with their sources. This article explores journalistic sourcing on apps (e.g., encrypted or not encrypted; open or one-to-one communication), and seeks to understand individual and systemic levels of trust. It finds that there are differences of trust depending on the functionalities of individual chat apps, and that interactions in journalistic sourcing in face-to-face and online environments affect the generation and output of news stories. Chat apps allow reporters to use open or closed networks, and adopt one of several approaches: trust the network, master the network, or abandon the network. These findings suggest that chat apps have an important role in communicating with sources, and should be a part of efforts to theorize journalistic sourcing.
Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
Authors: Pietras Eric M.
Published: September 2017

Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the same time, they must respond rapidly to acute needs such as infection or injury. Significant interest has emerged in how inflammation regulates HSC fate and how it affects the long-term functionality of HSCs and the blood system as a whole. Here we detail recent advances and unanswered questions at the intersection between inflammation and HSC biology in the contexts of development, aging, and hematological malignancy.
Optimization of sentiment analysis using machine learning classifiers
Authors: Singh Jaspreet , Singh Gurvinder , Singh Rajinder
Published: September 2017

Words and phrases bespeak the perspectives of people about products, services, governments and events on social media. Extricating positive or negative polarities from social media text denominates task of sentiment analysis in the field of natural language processing. The exponential growth of demands for business organizations and governments, impel researchers to accomplish their research in sentiment analysis. This paper leverages four state-of-the-art machine learning classifiers viz. Naïve Bayes, J48, BFTree and OneR for optimization of sentiment analysis. The experiments are performed using three manually compiled datasets; two of them are captured from Amazon and one dataset is assembled from IMDB movie reviews. The efficacies of these four classification techniques are examined and compared. The Naïve Bayes found to be quite fast in learning whereas OneR seems more promising in generating the accuracy of 91.3% in precision, 97% in F-measure and 92.34% in correctly classified instances.
Magnetic resonance imaging performance for diagnosis of ovarian torsion in pregnant women with stimulated ovaries
Authors: Asch Elizabeth , Wei Jesse , Mortele Koenraad J. , Humm Kathryn , Thornton Kim , Levine Deborah
Published: September 2017

Background

To determine if asymmetric ovarian edema on non-contrast MRI can be used to distinguish torsed from non-torsed stimulated ovaries in pregnant women.

Methods

In this retrospective study, our radiology database was searched for women who were pregnant and who had undergone ovarian stimulation and underwent MRI abdomen/pelvis from 1/2000–12/2012. At our institution, ultrasound is typically performed as a first line study for pregnant women with pelvic pain, with MR for those patients with indeterminate findings. 64 pregnant women (gestational age range 3–37 weeks) were included. MRI indication, prospective interpretation, operative diagnosis, and follow-up were recorded. Two blinded radiologists (with a third radiologist tie-breaker) independently measured and described the ovaries, including the likelihood of torsion. If one or both ovaries/adnexa had an underlying lesion such as a dermoid, cystadenoma, or abscess, the patient was excluded from size and signal intensity comparison (N = 14). For the remaining 50 women, comparison was made of the ovaries in women with normal ovaries (N = 27), stimulated ovaries without torsion (N = 11), non-stimulated ovaries with torsion (N = 3), and stimulated ovaries with torsion (N = 3). Patients with asymmetric ovarian edema without stimulation or torsion (N = 3) and with polycystic ovary syndrome (N = 3) were analyzed separately.

Results

Average normal ovarian length was 3.2 cm, compared to 4.5 cm for asymmetric edema and 5.6–8.8 cm for the other four groups. Average difference in greatest right and left ovarian diameter was 19% for normal ovaries compared to 24–37% for the other 5 groups. Asymmetric signal on T2-weighted imaging (T2WI) was seen in 12% (3/27) of normal ovaries compared to 9% (1/11) of stimulated patients without torsion, 33% (1/3) of patients with PCOS and 67% (2/3) of patients with torsion both without and with stimulation. The correct diagnosis of torsion was made prospectively in 5/6 cases but retrospectively in only 3/6 cases. In patients with stimulation, correct diagnosis of torsion was made in 2/3 cases prospectively (both with asymmetric T2 signal) and retrospectively in only 1/3 cases. In 13/64 patients, other acute gynecologic and non-gynecologic findings were diagnosed on MRI.

Conclusions

Enlarged edematous ovary can be seen with ovarian stimulation, ovarian torsion, or both. Although asymmetric ovarian edema occurred more frequently in patients with torsion than without, in pregnant patients with stimulated ovaries referred for MRI (typically after non-diagnostic ultrasound), ovarian torsion could not be confidently diagnosed or excluded retrospectively with non-contrast MRI.
Draft genome sequence of the cellulolytic endophyte Chitinophaga costaii A37T2T
Authors: Proença Diogo N. , Whitman William B. , Shapiro Nicole , Woyke Tanja , Kyrpides Nikos C. , Morais Paula V.
Published: September 2017

Here we report the draft genome sequence of Chitinophaga costai A37T2T (=CIP 110584T, =LMG 27458T), which was isolated from the endophytic community of Pinus pinaster tree. The total genome size of C. costaii A37T2T is 5.07 Mbp, containing 4204 coding sequences. Strain A37T2T encoded multiple genes likely involved in cellulolytic, chitinolytic and lipolytic activities. This genome showed 1145 unique genes assigned into 109 Cluster of Orthologous Groups in comparison with the complete genome of C. pinensis DSM 2588T. The genomic information suggests the potential of the strain A37T2T to interact with the plant metabolism. As there are only a few bacterial genomes related to Pine Wilt Disease, this work provides a contribution to the field.
Implementing a Multidisciplinary Approach to Enhance Compliance With Guideline-Recommended Prechemotherapy Pneumococcal Vaccination in a Military-Based Medical Oncology Practice
Authors: Delacruz Wilfred , Terrazzino Sandra , Osswald Michael , Payne Casey , Haney Brian
Published: September 2017

Purpose:

Patients with cancer are at increased risk for invasive pneumococcal disease, including community-acquired pneumonia. Current Advisory Committee on Immunization Practices and National Cancer Comprehensive Network guidelines recommend pneumococcal vaccination for immunocompromised patients, including patients with cancer.

Methods:

We conducted a quality improvement (QI) project to enhance compliance with pneumococcal vaccination in patients before their chemotherapy. Baseline pneumococcal vaccination rates were gathered from July 2013 to June 2014. We reviewed the current guidelines for pneumococcal vaccinations in patients with cancer with physicians and encouraged them to prescribe the pneumococcal vaccination to patients before therapy. We also recruited our clinic nurse practitioner, who meets all patients for chemotherapy teaching, to prescribe the vaccine to patients younger than 65 years of age.

Results:

During the baseline period, of the 110 patients younger than 65 years who received chemotherapy, seven (6.4%) received the pneumococcal vaccine. Of the 90 patients (median age, 60 years; range, 20 to 86 years) who received chemotherapy during the study period, 58 were younger than 65 years, of whom three patients were already vaccinated before their diagnosis. Twenty-five (45.5%) patients were vaccinated through our QI project. We have improved our compliance with pneumococcal vaccination by 39% ( P < .001).

Conclusion:

We have improved compliance with pneumococcal vaccination in patients with cancer receiving chemotherapy in our clinic through a QI project. We found that screening is best accomplished by a single person who is able to screen all patients. This practice is now a standard of care in our clinic.
Recovery From Ropivacaine-Induced or Levobupivacaine-Induced Cardiac Arrest in Rats: Comparison of Lipid Emulsion Effects
Authors: Yoshimoto Masashi , Horiguchi Takashi , Kimura Tetsu , Nishikawa Toshiaki
Published: September 2017

BACKGROUND:

Lipid emulsion treatment appears to have application in the treatment of local anesthetic–induced cardiac arrest. To examine whether the efficacy of lipid resuscitation in the treatment of local anesthetic–induced cardiac arrest is affected by lipophilicity, the effects of lipid infusions were compared between levobupivacaine-induced (high lipophilicity) and ropivacaine-induced (lower lipophilicity) rat cardiac arrest model.

METHODS:

A total of 28 female Sprague-Dawley rats were anesthetized using sevoflurane, which subsequently underwent tracheostomy, followed by femoral artery and vein cannulation. Two hours after the discontinuation of sevoflurane, either levobupivacaine 0.2% (n = 14) or ropivacaine 0.2% (n = 14) was administered at a rate of 2 mg/kg/min to the awake rats. When the pulse pressure decreased to 0, the infusion of local anesthetic was discontinued, and treatment with chest compressions and ventilation with 100% oxygen were immediately initiated. The total doses of local anesthetics needed to trigger the first seizure and pulse pressure of 0 mm Hg were calculated. The 2 groups were each subdivided into a lipid emulsion group (n = 7) and a control group (n = 7). In the lipid emulsion group, 20% lipid emulsion was administered intravenously (5 mL/kg bolus plus continuous infusion of 0.5 mL/kg/min), while in the control group, the same volume of normal saline was administered. Chest compressions were discontinued when the rate-pressure product had increased by more than 20% of baseline.

RESULTS:

The cumulative doses of levobupivacaine and ropivacaine that produced seizures and 0 pulse pressure showed no significant difference. Mean arterial blood pressure (MAP) values were higher in the levobupivacaine group than in the ropivacaine group after resuscitation was initiated (P < .05). In levobupivacaine-induced cardiac arrest, heart rate and MAP values were higher in the lipid group than in the control group after starting resuscitation (P < .05); all rats in the lipid group achieved spontaneous circulation (rate-pressure product >20% baseline), while only 2 of 7 rats in the control group achieved spontaneous circulation at 10 minutes. In ropivacaine-induced cardiac arrest, there were no significant differences in heart rate and MAP between the lipid and control groups from the start of resuscitation to 10 minutes; spontaneous circulation returned in 6 of 7 lipid group rats, but in only 2 of 7 control group rats at 10 minutes.

CONCLUSIONS:

Lipid emulsion treatment was more effective for levobupivacaine-induced cardiac arrest than for ropivacaine-induced cardiac arrest. Although lipid therapy is also effective for ropivacaine-induced cardiac arrest, it takes more time than in levobupivacaine-induced cardiac arrest. This suggests that the lipophilicity of local anesthetics influences the efficacy of lipid infusion when treating cardiac arrest caused by these drugs.
Automated Wormscan
Authors: Puckering Timothy , Thompson Jake , Sathyamurthy Sushruth , Sukumar Sinduja , Shapira Tirosh , Ebert Paul
Published: September 2017

There has been a recent surge of interest in computer-aided rapid data acquisition to increase the potential throughput and reduce the labour costs of large scale Caenorhabditis elegans studies. We present Automated WormScan, a low-cost, high-throughput automated system using commercial photo scanners, which is extremely easy to implement and use, capable of scoring tens of thousands of organisms per hour with minimal operator input, and is scalable. The method does not rely on software training for image recognition, but uses the generation of difference images from sequential scans to identify moving objects. This approach results in robust identification of worms with little computational demand. We demonstrate the utility of the system by conducting toxicity, growth and fecundity assays, which demonstrate the consistency of our automated system, the quality of the data relative to manual scoring methods and congruity with previously published results.
The future of metabolomics in ELIXIR
Authors: van Rijswijk Merlijn , Beirnaert Charlie , Caron Christophe , Cascante Marta , Dominguez Victoria , Dunn Warwick B. , Ebbels Timothy M. D. , Giacomoni Franck , Gonzalez-Beltran Alejandra , Hankemeier Thomas , Haug Kenneth , Izquierdo-Garcia Jose L. , Jimenez Rafael C. , Jourdan Fabien , Kale Namrata , Klapa Maria I. , Kohlbacher Oliver , Koort Kairi , Kultima Kim , Le Corguillé Gildas , Moschonas Nicholas K. , Neumann Steffen , O’Donovan Claire , Reczko Martin , Rocca-Serra Philippe , Rosato Antonio , Salek Reza M. , Sansone Susanna-Assunta , Satagopam Venkata , Schober Daniel , Shimmo Ruth , Spicer Rachel A. , Spjuth Ola , Thévenot Etienne A. , Viant Mark R. , Weber Ralf J. M. , Willighagen Egon L. , Zanetti Gianluigi , Steinbeck Christoph
Published: September 2017

Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for metabolomics within Europe, a workshop on the “Future of metabolomics in ELIXIR” was organised at Frankfurt Airport in Germany. This one-day strategic workshop involved representatives of ELIXIR Nodes, members of the PhenoMeNal consortium developing an e-infrastructure that supports workflow-based metabolomics analysis pipelines, and experts from the international metabolomics community. The workshop established metabolite identification as the critical area, where a maximal impact of computational metabolomics and data management on other fields could be achieved. In particular, the existing four ELIXIR Use Cases, where the metabolomics community - both industry and academia - would benefit most, and which could be exhaustively mapped onto the current five ELIXIR Platforms were discussed. This opinion article is a call for support for a new ELIXIR metabolomics Use Case, which aligns with and complements the existing and planned ELIXIR Platforms and Use Cases.
Foreword
Authors: Lindström Liina , Huumo Tuomas
Published: September 2017

Foreword
RETRACTED: Comparison and application of wavelet transform and Kalman filtering for denoising in δ13CO2 measurement by tunable diode laser absorption spectroscopy at 2.008 µm
Authors: Niu Ming-sheng , Han Pei-gao , Song Lian-ke , Hao Dian-zhong , Zhang Jing-hu , Ma Lili
Published: September 2017

We propose to use the wavelet transform and Kalman filter methods for processing noise in δ13CO2 measurement using laser absorption spectroscopy at 2.008 µm and they have been shown to be useful tool for reducing the intrinsic noise of the optical system. Through the performance comparison and analysis of these two denoising techniques for the intrinsic noise reduction of optical system, it can be found that the Kalman filter is a more suitable approach for the extraction of gas isotope measurement signal from a contaminated signal.
Social media, youth and everyday life in Kenya
Authors: Ndlela Martin N. , Mulwo Abraham
Published: September 2017

With an increasing accessibility of smartphones and mobile Internet, social media are becoming an integral part of everyday life for young people in Kenya. The use of new social media tools like Facebook, Twitter and WhatsApp is quickly changing in the country. Previous research on new media, however, indicates socio-demographic differences in the access, appropriation and use of new technologies. This article aims at advancing our understanding of how young people in developing countries are appropriating and using new social media platforms. It examines the multiple ways in which young people in Kenya use social media platforms and how they use these new spaces to connect, interact, communicate and engage on different issues. The article argues that the new social media configurations are invariably making possible access to alternative spaces, relatively ‘free’ from mainstream communication platforms. These changes have implications on different aspects of social change processes such as sociocultural and socio-economic changes in the Kenya.
Fundación Educación Católica: Profecía, proyecto y transformación. Reafirmar el compromiso y actualizar la misión
Authors: Yagüe Juan Ignacio , Alonso Óscar
Published: September 2017

Hace 25 años aparecía en España un fenómeno hasta entonces desconocido. Las instituciones religiosas, titulares de cientos de colegios a lo largo y ancho de toda nuestra geografía, comenzaban a vislumbrar la situación en la que nos encontramos en este momento: pocas vocaciones, el deseo de continuar adelante con las obras educativas y la responsabilidad de asumir verdaderamente la misión compartida junto con los laicos. Nacía así la Fundación Educación Católica, una profecía que con los años se ha consolidado en un proyecto educativo transformador y vanguardista.
AHP-De Borda: a hybrid multicriteria ranking method
Authors: Costa Helder Gomes
Published: September 2017

De Borda voting method was proposed in the period of French revolution to be used in a multiple decision-maker environment. Later, it was adapted to multicriteria ranking problems. The adoption of criteria weights in De Borda modeling is an evolution of the original De Borda method; despite this fact, evolution does not approach how to define the weights, that is: the weights are an input to De Borda. The proposal is to segment the problem into two ones. The first is a weight assignment problem and was approached through AHP modeling. The second problem is a ranking problem, being approached through De Borda method. AHP and De Borda are based in principles from different multicriteria Decision Schools: AHP is classified into the American School; De Borda is recognized as a French method. This paper shows that it is possible to use both methods, in a complementary way. The proposal can assist and support decision makers in the modeling of multicriteria ranking problems by assigning weights to the criteria under a systematized way. This hybrid approach proposes a better way for the structuring of the problem, by linking an approach that natively supports the assignment of weights (AHP) into another devoted to the ordering of objects (De Borda).
Capacity coordination in hybrid make-to-stock/make-to-order contexts using an enhanced multi-stage model
Authors: Rabbani Masoud , Motevali Haghighi Sara , Farrokhi-Asl Hamed , Manavizadeh Neda
Published: September 2017

One of the most attracting production systems that has recently been vastly explored by practitioners and academicians is hybrid make-to-stock/make-to-order. Having a hierarchical production planning structure considered, this paper develops a multi-stage model to cope with the operational decisions, including order acceptance/rejection, product lot sizing, overtime capacity planning, outsourcing, and due date setting. Moreover, the proposed framework also comprises providing alternative products for the coming orders in order to enhance service level of the firm to the customers. In order to validate the presented framework, it is applied in a real industrial case study and the obtained results approve validity of the proposed framework.