bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Anticipated Emotions in Moral	Transgressions
Authors: Jansma Dorinde , Malti Tina , Opdenakker Marie-Christine , van der Werf Greetje
Published: March 2018

Abstract. This paper describes the reliability and validity of the assessment of anticipated emotions in the context of moral transgressions in a sample of 1,179 children aged 6–13 years (M = 9.1; SD = 1.8, 49.0% girls), with a special interest in the domain and developmental specificity of the instrument. To evaluate the concurrent and predictive validity, we also examined the relation between anticipated emotions and antisocial and prosocial tendencies and sympathy at two time points. The instrument consisted of six transgression scenarios covering three domains: unfairness (not winning fairly, not keeping word), omission of a prosocial duty (not sharing, not helping), and victimization (verbal bullying, relational bullying). Results show sufficient internal consistency and a one-factor structure of the anticipated emotions, indicating a lack of domain variability of the assessment of anticipated emotions. Additionally, emotions following hypothetical moral transgressions showed some developmental variability. Whereas no relation was found between anticipated emotions and antisocial tendencies, anticipated negative emotions following the moral transgressions were positively related to prosocial tendencies and sympathy. This provides preliminary evidence for the concurrent and predictive validity of the instrument.
Automated brightfield morphometry of 3D organoid populations by OrganoSeg
Authors: Borten Michael A. , Bajikar Sameer S. , Sasaki Nobuo , Clevers Hans , Janes Kevin A.
Published: March 2018

Spheroid and organoid cultures are powerfulin vitromodels for biology, but size and shape diversity within the culture is largely ignored. To streamline morphometric profiling, we developed OrganoSeg, an open-source software that integrates segmentation, filtering, and analysis for archived brightfield images of 3D culture. OrganoSeg is more accurate and flexible than existing platforms, and we illustrate its potential by stratifying 5167 breast-cancer spheroid and 5743 colon and colorectal-cancer organoid morphologies. Organoid transcripts grouped by morphometric signature heterogeneity were enriched for biological processes not prominent in the original RNA sequencing data. OrganoSeg enables complete, objective quantification of brightfield phenotypes, which may give insight into the molecular and multicellular mechanisms of organoid regulation.
Enhanced protection of the renal vascular endothelium improves early outcome in kidney transplantation: Preclinical investigations in pig and mouse
Authors: Nordling Sofia , Brännström Johan , Carlsson Fredrik , Lu Bo , Salvaris Evelyn , Wanders Alkwin , Buijs Jos , Estrada Sergio , Tolmachev Vladimir , Cowan Peter J. , Lorant Tomas , Magnusson Peetra U.
Published: March 2018

Ischemia reperfusion injury is one of the major complications responsible for delayed graft function in kidney transplantation. Applications to reduce reperfusion injury are essential due to the widespread use of kidneys from deceased organ donors where the risk for delayed graft function is especially prominent. We have recently shown that coating of inflamed or damaged endothelial cells with a unique heparin conjugate reduces thrombosis and leukocyte recruitment. In this study we evaluated the binding capacity of the heparin conjugate to cultured human endothelial cells, to kidneys from brain-dead porcine donors, and to murine kidneys during static cold storage. The heparin conjugate was able to stably bind cultured endothelial cells with high avidity, and to the renal vasculature of explanted kidneys from pigs and mice. Treatment of murine kidneys prior to transplantation reduced platelet deposition and leukocyte infiltration 24 hours post-transplantation, and significantly improved graft function. The present study thus shows the benefits of enhanced protection of the renal vasculature during cold storage, whereby increasing the antithrombotic and anti-adhesive properties of the vascular endothelium yields improved renal function early after transplantation.
The immune contexture of hepatocellular carcinoma predicts clinical outcome
Authors: Foerster Friedrich , Hess Moritz , Gerhold-Ay Aslihan , Marquardt Jens Uwe , Becker Diana , Galle Peter Robert , Schuppan Detlef , Binder Harald , Bockamp Ernesto
Published: March 2018

The general relevance of the immune system for cancer development and therapy is increasingly recognized. However and although the immune contexture of most human cancer types has been determined, a global characterisation of the immune tumour microenvironment in hepatocellular carcinoma (HCC) is lacking. Equally, differences in the immune contexture of HCC between different patient subgroups and its effect on survival remain to be established. Here we report an in silico analysis of the immune contexture of human HCC. Using large deep sequencing HCC tumour, adjacent non-tumour and healthy liver high-dimensional data sets, we were able to reveal previously unrecognized differences in the immune contexture of HCC. Strikingly, we found that different etiologies and HCC stages were not associated with major changes in the immune contexture. In contrast, the presence of T cells and cytotoxic cells as well as the absence of macrophages and Th2 cells positively correlated with patient survival. Based on these novel findings, we developed a prognostic score that accurately distinguishes between patients with good and poor survival. Our study provides the first global characterisation of the immune contexture of HCC and will have direct implications for future HCC therapies.
HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence
Authors: Brandão Fabiana , Esher Shannon K. , Ost Kyla S. , Pianalto Kaila , Nichols Connie B. , Fernandes Larissa , Bocca Anamélia L. , Poças-Fonseca Marcio José , Alspaugh J. Andrew
Published: March 2018

The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic changes to promote its survival in specific ecological niches and inside the host. To explore the role of chromatin remodeling on the expression of virulence-related traits, we identified and deleted seven genes encoding predicted class I/II histone deacetylases (HDACs) in the C. neoformans genome. These studies demonstrated that individual HDACs control non-identical but overlapping cellular processes associated with virulence, including thermotolerance, capsule formation, melanin synthesis, protease activity and cell wall integrity. We also determined the HDAC genes necessary for C. neoformans survival during in vitro macrophage infection and in animal models of cryptococcosis. Our results identified the HDA1 HDAC gene as a central mediator controlling several cellular processes, including mating and virulence. Finally, a global gene expression profile comparing the hda1Δ mutant versus wild-type revealed altered transcription of specific genes associated with the most prominent virulence attributes in this fungal pathogen. This study directly correlates the effects of Class I/II HDAC-mediated chromatin remodeling on the marked phenotypic plasticity and virulence potential of this microorganism. Furthermore, our results provide insights into regulatory mechanisms involved in virulence gene expression that are likely shared with other microbial pathogens.
Monitoring the Age of Mosquito Populations Using Near-Infrared Spectroscopy
Authors: Lambert Ben , Sikulu-Lord Maggy T. , Mayagaya Vale S. , Devine Greg , Dowell Floyd , Churcher Thomas S.
Published: March 2018

Mosquito control with bednets, residual sprays or fumigation remains the most effective tool for preventing vector-borne diseases such as malaria, dengue and Zika, though there are no widely used entomological methods for directly assessing its efficacy. Mosquito age is the most informative metric for evaluating interventions that kill adult mosquitoes but there is no simple or reliable way of measuring it in the field. Near-Infrared Spectroscopy (NIRS) has been shown to be a promising, high-throughput method that can estimate the age of mosquitoes. Currently the ability of NIRS to measure mosquito age is biased, and has relatively high individual mosquito measurement error, though its capacity to rigorously monitor mosquito populations in the field has never been assessed. In this study, we use machine learning methods from the chemometric literature to generate more accurate, unbiased estimates of individual mosquito age. These unbiased estimates produce precise population-level measurements, which are relatively insensitive to further increases in NIRS accuracy when feasible numbers of mosquitoes are sampled. The utility of NIRS to directly measure the impact of pyrethroid resistance on mosquito control is illustrated, showing how the technology has potential as a highly valuable tool for directly assessing the efficacy of mosquito control interventions.
Author Correction: Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish
Authors: Ayaz Ahmed Khan Behlol , Raman Thiagarajan , Veerappan Anbazhagan
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1
Authors: Rathore Saima , Akbari Hamed , Rozycki Martin , Abdullah Kalil G. , Nasrallah MacLean P. , Binder Zev A. , Davuluri Ramana V. , Lustig Robert A. , Dahmane Nadia , Bilello Michel , O’Rourke Donald M. , Davatzikos Christos
Published: March 2018

The remarkable heterogeneity of glioblastoma, across patients and over time, is one of the main challenges in precision diagnostics and treatment planning. Non-invasive in vivo characterization of this heterogeneity using imaging could assist in understanding disease subtypes, as well as in risk-stratification and treatment planning of glioblastoma. The current study leveraged advanced imaging analytics and radiomic approaches applied to multi-parametric MRI of de novo glioblastoma patients (n = 208 discovery, n = 53 replication), and discovered three distinct and reproducible imaging subtypes of glioblastoma, with differential clinical outcome and underlying molecular characteristics, including isocitrate dehydrogenase-1 (IDH1), O6-methylguanine–DNA methyltransferase, epidermal growth factor receptor variant III (EGFRvIII), and transcriptomic subtype composition. The subtypes provided risk-stratification substantially beyond that provided by WHO classifications. Within IDH1-wildtype tumors, our subtypes revealed different survival (p < 0.001), thereby highlighting the synergistic consideration of molecular and imaging measures for prognostication. Moreover, the imaging characteristics suggest that subtype-specific treatment of peritumoral infiltrated brain tissue might be more effective than current uniform standard-of-care. Finally, our analysis found subtype-specific radiogenomic signatures of EGFRvIII-mutated tumors. The identified subtypes and their clinical and molecular correlates provide an in vivo portrait of phenotypic heterogeneity in glioblastoma, which points to the need for precision diagnostics and personalized treatment.
The impacts of regional transport and meteorological factors on aerosol optical depth over Beijing, 1980–2014
Authors: Gu Xingfa , Bao Fangwen , Cheng Tianhai , Chen Hao , Wang Ying , Guo Hong
Published: March 2018

Understanding the role of different sources that contribute to the aerosol extinction coefficient is an important aspect toward analyzing climate change and regional air quality. In Beijing specifically, the region has suffered severe air quality deterioration over the past three decades, but the magnitude of extraneous contributions to aerosol variation has remained uncertain. Therefore, we estimated trends of contributions to aerosol optical depth (AOD) for Beijing from 1980 to 2014 and built a seasonal regression model to decouple the extraneous contribution from the total emitted using ground-based aerosol and meteorological measurements, extended to the emissions of man-made and natural contribution. The variation of AOD over Beijing was significantly affected by the anthropogenic aerosol emissions, which experienced slight augmentation by 15.3% from 1980 to 2000, rapid inflation by 36.9% from 2000 to 2006, and a gradual decrease by 10.0% from 2006 to 2014. The extraneous contribution from wind and its associated languishing patterns explain the historical increase of regional AOD, which experienced about a 10% enhancement over the three stages. Other meteorological contributions show no significant trends over 35 years, except for the temperature inversion, which despite the weakened hygroscopic growth after 2006, still experiences a significant enhancement.
Brain activations associated with fearful experience show common and distinct patterns between younger and older adults in the hippocampus and the amygdala
Authors: Lin Chia-Shu , Wu Ching-Yi , Wu Shih-Yun , Lin Hsiao-Han
Published: March 2018

Revisiting threat-related scenes elicits fear and activates a brain network related to cognitive-affective processing. Prior experience may contribute to the present fearful experience. We aimed to investigate (a) patterns of brain activation associated with individual differences in past fearful experiences (pFear) and the present fear elicited by watching videos (eFear) and (b) age-related differences in the activation patterns. Forty healthy adults, including 20 younger adults (YA) and 20 older adults (OA), underwent functional magnetic resonance imaging while watching videos containing high- and low-threat scenes of medical treatment. Both age subgroups showed positive correlations between pFear and bilateral hippocampal activation. Only YA showed threat-related activation in the bilateral anterior insula and activation positively correlated with pFear in the bilateral S1 and the amygdala. The evidence suggests that the hippocampus, amygdala and S1 may play key roles in bridging past fearful experiences and the present fear elicited by revisiting visual scenes and that the interaction between memory and emotional processing may be age dependent.
Enhancing the recovery of a temporal sequence of images using joint deconvolution
Authors: Caramazza Piergiorgio , Wilson Kali , Gariepy Genevieve , Leach Jonathan , McLaughlin Stephen , Faccio Daniele , Altmann Yoann
Published: March 2018

In this work, we address the reconstruction of spatial patterns that are encoded in light fields associated with a series of light pulses emitted by a laser source and imaged using photon-counting cameras, with an intrinsic response significantly longer than the pulse delay. Adopting a Bayesian approach, we propose and demonstrate experimentally a novel joint temporal deconvolution algorithm taking advantage of the fact that single pulses are observed simultaneously by different pixels. Using an intensified CCD camera with a 1000-ps gate, stepped with 10-ps increments, we show the ability to resolve images that are separated by a 10-ps delay, four time better compared to standard deconvolution techniques.
Cross-platform mass spectrometry annotation in breathomics of oesophageal-gastric cancer
Authors: Chin Sung-Tong , Romano Andrea , Doran Sophie L. F. , Hanna George B.
Published: March 2018

Disease breathomics is gaining importance nowadays due to its usefulness as non-invasive early cancer detection. Mass spectrometry (MS) technique is often used for analysis of volatile organic compounds (VOCs) associated with cancer in the exhaled breath but a long-standing challenge is the uncertainty in mass peak annotation for potential volatile biomarkers. This work describes a cross-platform MS strategy employing selected-ion flow tube mass spectrometry (SIFT-MS), high resolution gas chromatography-mass spectrometry (GC-MS) retrofitted with electron ionisation (EI) and GC-MS retrofitted with positive chemical ionisation (PCI) as orthogonal analytical approaches in order to provide facile identification of the oxygenated VOCs from breath of cancer patients. In addition, water infusion was applied as novel efficient PCI reagent in breathomics analysis, depicting unique diagnostic ions M+ or [M-17]+ for VOC identification. Identity confirmation of breath VOCs was deduced using the proposed multi-platform workflow, which reveals variation in breath oxygenated VOC composition of oesophageal-gastric (OG) cancer patients with dominantly ketones, followed by aldehydes, alcohols, acids and phenols in decreasing order of relative abundance. Accurate VOC identification provided by cross-platform approach would be valuable for the refinement of diagnostic VOC models and the understanding of molecular drivers of VOC production.
Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus
Authors: Sireesh Dornadula , Dhamodharan Umapathy , Ezhilarasi Krishnamoorthy , Vijay Viswanathan , Ramkumar Kunka Mohanram
Published: March 2018

We investigated the association of redox regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) and inflammatory cytokines as well as clinical remission in patients with recent onset type 2 diabetes (DM). Blood was collected from 180 DM patients (105 males/75 females) and 150 control subjects (86 males/64 females). Blood glucose, HbA1c, lipid profile and Nrf2 levels were determined along with circulatory cytokines in study subjects. The data were adjusted with confounding factors such as age and sex using multiple logistic regression analysis. We found that Th1/Th2 and oxidative stress markers were significantly elevated, whereas Nrf2 and its downstream targets were decreased in peripheral blood mononuclear cells (PBMCs) of DM subjects when compared with control. The circulatory levels of Nrf2 showed a positive correlation with Th2 cytokines and negative correlation to Th1 cytokines. Further, the impaired insulin secretion in pancreatic β-cells observed due to cytokine stress has been restored by activation of Nrf2 as assessed by glucose-stimulated insulin secretion (GSIS). This study identifies Nrf2 plays a central role in skewing Th1 and Th2 dominance in the progression of diabetes.
Antimony measurements in environmental matrices: seven considerations
Authors: Maher William A. , Krikowa Frank , Foster Simon D. , Ellwood Michael J. , Bennett William W.
Published: March 2018

A variety of approaches for measuring the content and speciation of Sb in environmental matrices are discussed.
Recent advances in the application of indoles in multicomponent reactions
Authors: Mohammadi Ziarani Ghodsi , Moradi Razieh , Ahmadi Tahereh , Lashgari Negar
Published: March 2018

An overview on recent applications of indoles in multicomponent reactions for the synthesis of heterocyclic compounds is provided.
Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer
Authors: Emamzadeh Mandana , Desmaële Didier , Couvreur Patrick , Pasparakis George
Published: March 2018

A thermoresponsive block copolymer has been developed with the capability to co-carry two drug molecules and to augment their cytotoxic properties via direct cell membrane interaction with cancer cells.
Cytometrical analysis of the adverse effects of indican, indoxyl, indigo, and indirubin on rat thymic lymphocytes
Authors: Funakoshi Yurie , Azuma Ayako , Ishikawa Mizuki , Itsuki Satoru , Tamura Yasuaki , Kanemaru Kaori , Hirai Shogo , Oyama Yasuo
Published: March 2018

Many businesses thrive by producing health supplements from agricultural products, as exemplified by the production of functional (or health) foods using plants traditionally cultivated in rural areas.
The safety evaluation of food flavouring substances: the role of metabolic studies
Authors: Smith Robert L. , Cohen Samuel M. , Fukushima Shoji , Gooderham Nigel J. , Hecht Stephen S. , Guengerich F. Peter , Rietjens Ivonne M. C. M. , Bastaki Maria , Harman Christie L. , McGowen Margaret M. , Taylor Sean V.
Published: March 2018

The safety assessment of a flavour substance examines several factors, including metabolic and physiological disposition data. The present article provides an overview of the metabolism and disposition of flavour substances by identifying general applicable principles of metabolism to illustrate how information on metabolic fate is taken into account in their safety evaluation. The metabolism of the majority of flavour substances involves a series both of enzymatic and non-enzymatic biotransformation that often results in products that are more hydrophilic and more readily excretable than their precursors. Flavours can undergo metabolic reactions, such as oxidation, reduction, or hydrolysis that alter a functional group relative to the parent compound. The altered functional group may serve as a reaction site for a subsequent metabolic transformation. Metabolic intermediates undergo conjugation with an endogenous agent such as glucuronic acid, sulphate, glutathione, amino acids, or acetate. Such conjugates are typically readily excreted through the kidneys and liver. This paper summarizes the types of metabolic reactions that have been documented for flavour substances that are added to the human food chain, the methodologies available for metabolic studies, and the factors that affect the metabolic fate of a flavour substance.
Transverse solute dispersion in microfluidic paper-based analytical devices (μPADs)
Authors: Urteaga Raúl , Elizalde Emanuel , Berli Claudio L. A.
Published: March 2018

Key rules for the design of analytical operations based on the transverse solute dispersion in paper are provided.
A new functional membrane protein microarray based on tethered phospholipid bilayers
Authors: Chadli Meriem , Maniti Ofelia , Marquette Christophe , Tillier Bruno , Cortès Sandra , Girard-Egrot Agnès
Published: March 2018

A new membrane protein microarray based on peptide-tethered bilayer lipid membranes formed by the fusion of cell-free expressed proteoliposomes inside micropatterned microwells.
N-Aryltrifluoromethanesulfonimides as new trifluoromethylating agents for the (photo)catalyst-free functionalization of (hetero)aromatics
Authors: Torti Edoardo , Protti Stefano , Fagnoni Maurizio
Published: March 2018

An N-arylsulfonimide was successfully employed as a new reagent for the photoinduced trifluoromethylation of (hetero)aromatics. The reactions took place by UV irradiation, sunlight exposure and under continuous-flow conditions.
Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides
Authors: Lu Xiao-Yu , Hong Mei-Lan , Zhou Hai-Pin , Wang Yue , Wang Jin-Yu , Ge Xiu-Tao
Published: March 2018

The stereoselective synthesis of tri-substituted alkenes is challenging.
Defects and impurities induced structural and electronic changes in pyrite CoS2: first principles studies
Authors: Li Shengwen , Zhang Yanning , Niu Xiaobin
Published: March 2018

The defects and impurities in CoS2 may cause very localized gap states close to the Fermi level, modifying their electrochemical performances.
Fabrication of magnetic particles reinforced nano-hydroxyapatite/gelatin composite for selective Cr(vi) removal from water
Authors: Gopalakannan Venkatrajan , Periyasamy Soodamani , Viswanathan Natrayasamy
Published: March 2018

The presence of chromium ion in drinking water has been proven to be toxic and carcinogenic.
Shape-controlled electrodeposition of single Pt nanocrystals onto carbon nanoelectrodes
Authors: Huang Ke , Clausmeyer Jan , Luo Long , Jarvis Karalee , Crooks Richard M.
Published: March 2018

In this paper, we report the electrosynthesis and characterization of individual, shape-controlled Pt nanocrystals electrodeposited on carbon nanoelectrodes.
Aptamer-recognized carbohydrates on the cell membrane revealed by super-resolution microscopy
Authors: Jing Yingying , Cai Mingjun , Xu Haijiao , Zhou Lulu , Yan Qiuyan , Gao Jing , Wang Hongda
Published: March 2018

By using dSTORM, aptamer-recognized method was compared with lectin-recognized method on visualizing the detailed structure of GalNAc at the nanometer scale.
Application of 3D hierarchical monoclinic-type structural Sb-doped WO3 towards NO2 gas detection at low temperature
Authors: Qi Juanjuan , Chen Ke , Xing Yi , Fan Hua , Zhao Hewei , Yang Jie , Li Lidong , Yan Bingyi , Zhou Jing , Guo Lin , Yang Shihe
Published: March 2018

Currently, the development of semiconducting metal oxide (SMO)-based gas sensors with innovative modification and three-dimensional (3D) structural designs has become a significant scientific interest due to their potential for addressing key technological challenges.
Tuning pentacene based dye-sensitized solar cells
Authors: Kunzmann Andreas , Gruber Marco , Casillas Rubén , Tykwinski Rik R. , Costa Rubén D. , Guldi Dirk M.
Published: March 2018

Herein, the synthesis, photophysics and electrochemistry of new pentacenes, which are applied in dye-sensitized solar cells, are presented. The electrolyte is optimized using Li+ as an additive to enhance electron injection, giving rise to a unique injection event. This leads to a 3-fold increase from previous efficiencies in pentacene-based DSSCs.
Self-assembly of affinity-controlled nanoparticlesviahost–guest interactions for drug delivery
Authors: Xue Fangchao , Wang Yuquan , Zhang Qixiong , Han Songling , Zhang Fuzhong , Jin Taotao , Li Chenwen , Hu Houyuan , Zhang Jianxiang
Published: March 2018

Affinity nanoparticles formed by host–guest interaction-mediated self-assembly of cyclodextrin (CD)-containing copolymers can function as effective nanoplatforms for drug delivery.
Enantioselective amination of nitroolefins under base-free and water-rich conditions using chiral bifunctional phase-transfer catalysts
Authors: Zhu Junchao , Cui Dongxiao , Li Yuedan , He Jingxu , Chen Weiping , Wang Pingan
Published: March 2018

A highly enantioselective amination of nitroolefins was realized with l-tert-leucine derived squaramide-scaffold bifunctional phase-transfer catalysts under base-free and water-rich conditions.
Rh(iii)-Catalyzed synthesis of pyrazolo[1,2-a]cinnolines from pyrazolidinones and diazo compounds
Authors: Li Panpan , Xu Xiaoying , Chen Jiayi , Yao Hequan , Lin Aijun
Published: March 2018

Pyrazolo[1,2-a]cinnolines were achieved via a rhodium(iii)-catalyzed redox-neutral annulation procedure, exhibiting good regioselectivity and high functional group tolerability.
Computational study on GaCl3-mediated reactions of donor–acceptor cyclopropanes with aromatic aldehydes: mechanism and role of GaCl3 and aldehydes
Authors: Tu Peng-Cheng , Zhou Lin , Kirillov Alexander M. , Fang Ran , Yang Lizi
Published: March 2018

The mechanism and role of GaCl3 and aldehydes for the GaCl3-mediated reaction of donor–acceptor (D–A) cyclopropanes are clarified through our calculations.
Bio-template assisted synthesis of porous glutaraldehyde-polyethyleneimine particulate resin for selective copper ion binding and recovery
Authors: Kaur Simarpreet , Kempson Ivan , Xu Haolan , Nydén Magnus , Larsson Mikael
Published: March 2018

Porous ion-exchange resins with features of high selectivity, high capacity, fast adsorption kinetics and chemical stability over a wide pH range are attractive for extracting precious metals like copper and upcycling waste.
Photoluminescence properties of a ScBO3:Cr3+ phosphor and its applications for broadband near-infrared LEDs
Authors: Shao Qiyue , Ding Hao , Yao Leqi , Xu Junfeng , Liang Chao , Jiang Jianqing
Published: March 2018

A new NIR-emitting phosphor ScBO3:Cr3+ was investigated and its great potential for applications in broadband NIR pc-LEDs was demonstrated.
Understanding differences in Er3+–Yb3+ codoped glass and glass ceramic based on upconversion luminescence for optical thermometry
Authors: Hao Yingxin , Lv Shichao , Ma Zhijun , Qiu Jianrong
Published: March 2018

Optical thermometry comparison between glass and corresponding glass ceramic and understand difference for optimized temperature sensing materials.
Preparation of multi-layer nylon-6 nanofibrous membranes by electrospinning and hot pressing methods for dye filtration
Authors: Yu Yuxi , Ma Rui , Yan Shaole , Fang Jiyu
Published: March 2018

The formation of multi-layer nylon-6 (PA-6) nanofibrous membranes by electrostatic spinning coupled with a hot pressing process, and they can be used for efficient and continuous indigo dye filtration.
A coarse grained molecular dynamics simulation study on the structural properties of carbon nanotube–dendrimer composites
Authors: Kavyani Sajjad , Dadvar Mitra , Modarress Hamid , Amjad-Iranagh Sepideh
Published: March 2018

By coarse grained molecular dynamics, the effect of the size and hydrophilic/hydrophobic properties of the interior/exterior structures of the dendrimers in carbon nanotube–dendrimer composites has been studied, to find a stable composite with the capability to be used in drug delivery.
Highly permeable CHA membranes prepared by fluoride synthesis for efficient CO2/CH4 separation
Authors: Yu Liang , Holmgren Allan , Zhou Ming , Hedlund Jonas
Published: March 2018

Highly permeable CHA membranes were prepared in a fluoride synthesis gel by using all-silica CHA nanocrystals as seeds (20–200 nm) that were prepared using an improved method developed in the present work.
Recent advances in nitric oxide delivery for antimicrobial applications using polymer-based systems
Authors: Sadrearhami Zahra , Nguyen Thuy-Khanh , Namivandi-Zangeneh Rashin , Jung Kenward , Wong Edgar H. H. , Boyer Cyrille
Published: March 2018

The present review highlights the recent developments in NO-releasing polymeric biomaterials for antimicrobial applications.
A flexible humidity sensor based on silk fabrics for human respiration monitoring
Authors: Li Bintian , Xiao Gang , Liu Feng , Qiao Yan , Li Chang Ming , Lu Zhisong
Published: March 2018

In this study, a silk fabric-based human respiration sensor was fabricated by successive electroless plating of conductive interdigital electrodes and spray-coating of a graphene oxide sensing layer.
Correction: Novel dendritic large molecules as solution-processable thermally activated delayed fluorescent emitters for simple structured non-doped organic light emitting diodes
Authors: Godumala Mallesham , Choi Suna , Kim Hyung Jong , Lee Chiho , Park Sungnam , Moon Ji Su , Kim Si Woo , Kwon Jang Hyuk , Cho Min Ju , Choi Dong Hoon
Published: March 2018

Correction for ‘Novel dendritic large molecules as solution-processable thermally activated delayed fluorescent emitters for simple structured non-doped organic light emitting diodes’ by Mallesham Godumala et al., J. Mater. Chem. C, 2018, 6, 1160–1170.
Cystathionine β-lyase is involved in d-amino acid metabolism
Authors: Miyamoto Tetsuya , Katane Masumi , Saitoh Yasuaki , Sekine Masae , Homma Hiroshi
Published: March 2018

Non-canonical d-amino acids play important roles in bacteria including control of peptidoglycan metabolism and biofilm disassembly. Bacteria appear to produce non-canonical d-amino acids to adapt to various environmental changes, and understanding the biosynthetic pathways is important. We identified novel amino acid racemases possessing the ability to produce non-canonical d-amino acids in Escherichia coli and Bacillus subtilis in our previous study, whereas the biosynthetic pathways of these d-amino acids still remain unclear. In the present study, we demonstrated that two cystathionine β-lyases (MetC and MalY) from E. coli produce non-canonical d-amino acids including non-proteinogenic amino acids. Furthermore, MetC displayed d- and l-serine (Ser) dehydratase activity. We characterised amino acid racemase, Ser dehydratase and cysteine lyase activities, and all were higher for MetC. Interestingly, all three activities were at a comparable level for MetC, although optimal conditions for each reaction were distinct. These results indicate that MetC and MalY are multifunctional enzymes involved in l-methionine metabolism and the production of d-amino acids, as well as d- and l-Ser metabolism. To our knowledge, this is the first evidence that cystathionine β-lyase is a multifunctional enzyme with three different activities.
62–92 GHz low‐noise transformer‐coupled LNA in 90‐nm CMOS
Authors: Huang C.‐Y. , Liu J.Y.‐C.
Published: March 2018

A 69–92 GHz wideband low‐noise amplifier (LNA) in a 90‐nm CMOS process is presented. A transformer‐based shunt‐series feedback is designed to achieve a broad input matching and minimum noise figure (NF) simultaneously. Interstage matching is achieved by the on‐chip transformer. The proposed four‐stage common‐source LNA achieves a wide 3‐dB bandwidth of 23 GHz, a peak gain of 7.6 dB at 76 GHz, a minimum NF of 6.6 dB at 80 GHz, and an input 1‐dB compression point of −7 dBm. The circuit occupies an area of 0.675 × 0.87 mm2 and consumes 11.3 mW under a 1.2 V supply.
Analytic coarse alignment and calibration for inertial navigation system on swaying base assisted by star sensor
Authors: Lu Jiazhen , Liang Shufang , Yang Lie
Published: March 2018

Initial alignment and positioning assisted by star sensors have been a popular research direction for the inertial navigation system. In this study, an analytic method is proposed to achieve the integration implementation of coarse alignment, calibration and positioning for swaying base. Gyroscope bias, accelerometer bias and attitude estimations are given in analytical forms on the basis of the attitude matrix provided by the star sensor. Positioning can be realised by transforming the accelerometer calibration part when the position information is not available. Compared with the previous approaches, the proposed method establishes the intuitive relationship between the navigation parameters and sensor errors, and is easy to implement. Furthermore, the proposed method can be extended to moving base when the velocity measurement is available. Both the simulation and experimental results show that the proposal analytic method can provide both good initial attitude and sensor parameters for fine alignment process.
Cattle health monitoring system using wireless sensor network: a survey from innovation perspective
Authors: Sharma Bhisham , Koundal Deepika
Published: March 2018

Health monitoring of dairy cattle plays a vital role for increasing the dairy products supply worldwide. Nowadays farmers are showing less interest in dairy sector as animals are suffering from various ailing health issues, unpredictable killing diseases, and advanced breeding costs. Therefore, it is necessary for farmers to adopt efficient technical methods for cattle health monitoring to increase the milk production supply. This study documented various wireless sensor network (WSN)‐based automatic health monitoring systems for monitoring various diseases of dairy cattle. The main objective of WSN‐based intelligent monitoring systems in farm automation is to monitor the health of dairy cattle on regular basis. This monitoring system needs to be installed in local and remote locations of farms that will assist the concerned farmers in monitoring their cattle activities from diverse locations for the whole day. All collected factors from the automated system will be stored in a database. Subsequently, with the help of farm automation, farmers can retrieve information for the execution of correct farm control strategies. Moreover, WSN is low‐cost technology which is specific for the identification of diseases in dairy animals. This revolution in advanced technological farm automation will aid in improving the productivity rate with the reduction of human intervention. This review study concludes all cattle monitoring systems along with various issues and challenges.
Optimal hops for minimal route power under SINR constraints in wireless sensor networks
Authors: Lambor Shilpa M. , Joshi Sangeeta M.
Published: March 2018

This study attempts to deduce the optimal hops in a multi‐hop wireless sensor network (WSN) ensuring power‐efficient communication under signal‐to‐interference noise ratio (SINR) constraints. The authors model the total route power consumption under wireless channel quality constraints. WSNs usually employ a multiple‐source, single‐sink structure for information transfer, necessitating data aggregation. The authors calculate optimal hops for three different data aggregation schemes. They further propose a robust hybrid data aggregation strategy that demonstrates an improved performance with respect to minimal power consumption when compared with employing individual data aggregation schemes. The data aggregation scheme employing optimal hops has been implemented and results have been verified for an illustrative application in water supply and drainage monitoring system. The authors have formulated the problem as a standard convex optimisation problem. They employ Karush–Kuhn–Tucker optimality conditions to derive the analytical expressions of the globally optimal hops, which incorporate the influence of route power, receiver noise, and SINR thresholds. The transmit power and hop count are varied simultaneously until an optimised hop count is achieved. The relation between the node transmit power and the number of hops in the route is derived and the condition for feasible optimal hops is presented.
Iron-peak elements Sc, V, Mn, Cu, and Zn in Galactic bulge globular clusters
Authors: Ernandes H. , Barbuy B. , Alves-Brito A. , Friaça A. , Siqueira-Mello C. , Allen D. M.
Published: March 2018

Aims. Globular clusters are tracers of the history of star formation and chemical enrichment in the early Galaxy. Their abundance pattern can help understanding their chemical enrichment processes. In particular, the iron-peak elements have been relatively little studied so far in the Galactic bulge.

Methods. The main aim of this work is to verify the strength of abundances of iron-peak elements for chemical tagging in view of identifying different stellar populations. Besides, the nucleosynthesis processes that build these elements are complex, therefore observational data can help constraining theoretical models, as well as give suggestions as to the kinds of supernovae that enriched the gas before these stars formed.

Results. The abundances of iron-peak elements are derived for the sample clusters, and compared with bulge field, and thick disk stars. We derived abundances of the iron-peak elements Sc, V, Mn, Cu, and Zn in individual stars of five bulge globular clusters (NGC 6528, NGC 6553, NGC 6522, NGC 6558, HP 1), and of the reference thick disk/or inner halo cluster 47 Tucanae (NGC 104). High resolution spectra were obtained with the UVES spectrograph at the Very Large Telescope over the years.

Conclusions. The sample globular clusters studied span metallicities in the range –1.2 ≲ [Fe/H] ≲ 0.0. V and Sc appear to vary in lockstep with Fe, indicating that they are produced in the same supernovae as Fe. We find that Mn is deficient in metal-poor stars, confirming that it is underproduced in massive stars; Mn-over-Fe steadily increases at the higher metallicities due to a metallicity-dependent enrichment by supernovae of type Ia. Cu behaves as a secondary element, indicating its production in a weak-s process in massive stars. Zn has an alpha-like behaviour at low metallicities, which can be explained in terms of nucleosynthesis in hypernovae. At the metal-rich end, Zn decreases with increasing metallicity, similarly to the alpha-elements.
The changing use of the ovipositor in host shifts by ichneumonid ectoparasitoids of spiders (Hymenoptera, Ichneumonidae, Pimplinae)
Authors: Takasuka Keizo , Fritzén Niclas R. , Tanaka Yoshihiro , Matsumoto Rikio , Maeto Kaoru , Shaw Mark R.
Published: March 2018

Accurate egg placement into or onto a living host is an essential ability for many parasitoids, and changes in associated phenotypes, such as ovipositor morphology and behaviour, correlate with significant host shifts. Here, we report that in the ichneumonid group of koinobiont spider-ectoparasitoids (“polysphinctines”), several putatively ancestral taxa (clade I here), parasitic on ground-dwelling RTA-spiders (a group characterised by retrolateral tibial apophysis on male palpal tibiae), lay their eggs in a specific way. They tightly bend their metasoma above the spider’s cephalothorax, touching the carapace with the dorsal side of the ovipositor apically (“dorsal-press”). The egg slips out from the middle part of the ventral side of the ovipositor and moves towards its apex with the parted lower valves acting as rails. Deposition occurs as the parasitoid draws the ovipositor backwards from under the egg. Oviposition upon the tough carapace of the cephalothorax, presumably less palatable than the abdomen, is conserved in these taxa, and presumed adaptive through avoiding physical damage to the developing parasitoid. This specific way of oviposition is reversed in the putatively derived clade of polysphinctines (clade II here) parasitic on Araneoidea spiders with aerial webs, which is already known. They bend their metasoma along the spider’s abdomen, grasping the abdomen with their fore/mid legs, pressing the ventral tip of the metasoma and the lower valves of the ovipositor against the abdomen (“ventral-press”). The egg is expelled through an expansion of the lower valves, which is developed only in this clade and evident in most species, onto the softer and presumably more nutritious abdomen.
Solidification of Nanostructured Lipid Carriers Loaded Testosterone Undecanoate: In Vivo and In Vitro Study
Authors: Hua Yabing , Li Wanqing , Cheng Zhou , Zhao Ziming , Yin Xiaoxing , Li Ying , Sun Jianxu , Gao Jing , Zhang Hui , Zheng Aiping
Published: March 2018

To enhance the bioavailability of testosterone undecanoate (TU) and overcome the current problem of soft capsules (Andriol Testocaps®), Nano-structured lipid carriers (NLC) for TU was developed. First, suspension of TU-loaded NLC (TU-NLC) was prepared by high pressure homogenization; then adsorbent or a protective agent β-cyclodextrin was used to solidify the suspension through a vacuum system; finally, the solid powder of TU-loaded NLC (solid TU-NLC) was filled into hard capsules. The characteristics of solid TU-NLC, were investigated in vitro and vivo. The particle size of TU-NLC was about 273.3 nm, the potential was 0.156±0.04. Transmission electron microscope (TEM) revealed that the NLC was spherical and uniform. Differential scanning calorimetry (DSC) suggested the drug had been encapsulated into NLC lipid matrix. The drug release proved that solid TU-NLC showed a higher dissolution in vitro. The CaCO-2 cell permeability showed that solid TU-NLC could enhance trans-membrane absorption of the TU. Moreover, the AUC of solid TU-NLC formulations (4304±550.50 μg/L*min) was higher than commercial product Andriol Testocaps® (3075±372.50 μg/L*min). In conclusion, solid TU-NLC could enhance the rate of dissolution, and had a relatively higher bioavailability than Andriol Testocaps® in vivo Graphical Abstract.
A case of severe gouty tophi-induced carpal tunnel syndrome: Operative finding and its outcome
Authors: Lee Jun-Ku , Kim Ju Won , Kim Yoon Seok , Koo Bon San
Published: March 2018

Introduction

Gout is a disease featuring acute arthritis, joint deformity and severe pain caused through the deposition of monosodium urate crystals in and around synovial tissue
1. Tophi are stone-like deposits of monosodium urate in the soft tissues, synovial tissues, or bones adjacent to the joints.
The tophi can compromise joint motion and deteriorate bony structure, finally leading to functional disability. Therefore, early treatment using uric acid lowering
agents is standard practice in gout patients to prevent the formation of tophi through controlling uric acid levels.
HaMiPla erscheint im 50. Jahrgang
Authors: Prommersberger Karl-Josef
Published: March 2018

Erstmals erschienen im März 1969, damals noch unter dem Namen „Handchirurgie“, ab 1982 unter dem Namen Handchirurgie Mikrochirurgie Plastische Chirurgie erscheint
die HaMiPla, wie unsere Zeitschrift liebevoll und kurz genannt wird, 2018 mit ihrem 50. Jahrgang. Ob das ein Grund ist stolz zu sein? Ich glaube schon. Meines
Wissens ist die HaMiPla damit die älteste speziell der Handchirurgie gewidmete Fachzeitschrift weltweit, erscheint doch z. B. die amerikanische Ausgabe des The
Journal of Hand Surgery erst im 43. Jahrgang und dies, obwohl die amerikanische Gesellschaft für Handchirurgie viel älter als die deutsche ist. Darüber ist noch zu
sprechen.
Nutrigenomic Information in the openEHR Data Set
Authors: Maranhão Priscila , Bacelar-Silva Gustavo , Ferreira Duarte , Calhau Conceição , Vieira-Marques Pedro , Cruz-Correia Ricardo
Published: March 2018

Background The traditional concept of personalized nutrition is based on adapting diets according to individual needs and preferences. Discussions about personalized nutrition have been on since the Human Genome Project, which has sequenced the human genome. Thenceforth, topics such as nutrigenomics have been assessed to help in better understanding the genetic variation influence on the dietary response and association between nutrients and gene expression. Hence, some challenges impaired the understanding about the nowadays important clinical data and about clinical data assumed to be important in the future.

Objective Finding the main clinical statements in the personalized nutrition field (nutrigenomics) to create the future-proof health information system to the openEHR server based on archetypes, as well as a specific nutrigenomic template.

Methods A systematic literature search was conducted in electronic databases such as PubMed. The aim of this systemic review was to list the chief clinical statements and create archetype and templates for openEHR modeling tools, namely, Ocean Archetype Editor and Ocean Template Design.

Results The literature search led to 51 articles; however, just 26 articles were analyzed after all the herein adopted inclusion criteria were assessed. Of these total, 117 clinical statements were identified, as well as 27 archetype-friendly concepts. Our group modeled four new archetypes (waist-to-height ratio, genetic test results, genetic summary, and diet plan) and finally created the specific nutrigenomic template for nutrition care.

Conclusion The archetypes and the specific openEHR template developed in this study gave dieticians and other health professionals an important tool to their nutrigenomic clinical practices, besides a set of nutrigenomic data to clinical research.
Malign Differentiation of a Large Buschke Loewenstein Tumor in Penis
Authors: Akdag Osman , Yildiran Gokce
Published: March 2018

Buschke–Loewenstein tumor (BLT) is a giant condyloma acuminatum which is very rare and commonly affects the anogenital region. The malignant transformation and localization in penis is very rare. This article aims to present a case with BLT with malignant transformation in penis.

A 59-year-old male patient was referred, who has have been suffering from a cauliflower-like lesion in the penis for 8 years. Biopsies revealed a BLT with malignant transformation. The lesion was excised largely and reconstructed with local flaps and skin grafts.

Defined by Buschke and Loewenstein in 1925, giant condyloma acuminatum is a rare and important disorder because of the sexually transmitting capability.