bluuebunny/crossref_metadata_2025 huggingface dataset:
A UFRRJ COMO IDENTIDADE TERRITORIAL: A ESPACIALIDADE E A TERRITORIALIDADE AFETIVA DA INSTITUIÇÃO
Authors: Lima Marluce de Souza Oliveira , Da Silva Robson Dias
Published: March 2023

O objetivo desta pesquisa é apresentar a UFRRJ como parte integrante do território de Seropédica, municí­pio do Estado do Rio de Janeiro, sob a ótica de um agente de mudanças e a personificação do que é urbano em um espaço considerado rural. Para além do desenvolvimento urbano da região, busca-se compreender o sentimento de pertença ao espaço imaginário da Rural, quando são indicadas as relações criadas em torno de uma dimensão territorial que se conecta aos sujeitos que por ela percorrem, as quais ajudam a evidenciar uma identidade construí­da pela reciprocidade nas relações de afetividade, confiança e reconhecimento. Esta investigação se conduzirá qualitativamente, com o emprego de alguns recursos da pesquisa quantitativa, no que diz respeito à quantificação de alguns de seus dados. Os territórios da UFRRJ criados pelo Plano Expansão/REUNI possuem identidades, das quais inferimos que sejam diversas daquela que conhecemos por intermédio da eloquência de quem cursou a sua graduação ou pós-graduação no campus Seropédica. O projeto de reestruturação e expansão da UFRRJ reforçou aquilo que já percebí­amos, tal como o discurso de um egresso do Campi ou mesmo de um ex-servidor ressaltando o quanto o espaço ocupado outrora foi importante para a sua formação acadêmica, ou a sua formação profissional, seja por um corpo de docentes cativantes, por um ambiente propí­cio a grandes desafios profissionais, ou por simplesmente usufruir de uma atmosfera exuberante da natureza, construí­da e pensada para acolher aqueles que buscam o saber acadêmico, mesmo que este não fosse o seu objetivo inicial.
Editorial
Authors: Cavalcanti Neto Sebastião
Published: March 2023

Editorial escrito pelo professor Sebastião Cavalcanti Neto
O COMPLIANCE NA ADMINISTRAÇÃO PÚBLICA BRASILEIRA
Authors: Valle da Costa Neto Alcelyr , Antonio Evangelista de Souza Netto  , Priscila Luciene Santos de Lima  , Flávia Jeane Ferrari  , Silvia De Jesus Martins
Published: March 2023

O objetivo do presente estudo é analisar o compliance por meio dos códigos de conduta no âmbito da Administração Pública nacional. A temática justifica-se diante da imprescindível necessidade das instituições não só privadas, mas principalmente de interesse público demonstrem programas de gestão de riscos e de anticorrupção em suas governanças, a fim de otimizar a sua credibilidade e exemplo diante da sociedade. O trabalho busca analisar quais são os códigos de conduta do servidor público brasileiro e as respectivas práticas de compliance dentro desta instituição pública. Para tal, desenvolve-se uma pesquisa de abordagem qualitativa, de procedimento bibliográfico amparada na legislação vigente, nas normas internas institucionais, além da literatura referente ao tema abordado. Observou-se que a Administração Pública Brasileira, no contexto de seus princípios e valores, demonstra ser um ambiente bastante favorável à introdução do compliance.

Palavras-chave: Administração Pública; Compliance; Programas de Integridade.
FRAGILIDADE DO λόγος
Authors: Cruz Estevão Lemos
Published: March 2023

Platão, na Carta VII, adverte acerca da fragilidade do λόγος predicativo e sua consequente incapacidade de abordar o ser dos entes. Mas em que consiste tal fragilidade? O presente artigo visa investigar a estrutura do λόγος predicativo desenhado por Platão na Carta VII a fim de encontrar os fundamentos de sua fragilidade. Da investigação resultará que o λόγος predicativo jamais poder ser uma via de acesso primeira aos entes.
ARISTÓTELES NA PERSPECTIVA DA LIBERDADE INTELECTUAL NA OBRA SOBRE A LIBERDADE DA VONTADE DE SCHOPENHAUER
Authors: Alves Antonio
Published: March 2023

No presente artigo tive por objetivo fazer um estudo a respeito da influência de Schopenhauer em relação a Aristóteles a partir do conceito de liberdade intelectual na obra Sobre a liberdade da vontade, texto apresentado pelo filósofo como resposta ao concurso de 1837 realizado pela Sociedade Real Norueguesa de Ciências de Trondheim. Para tal empreendimento busquei a partir do conceito de liberdade intelectual de Schopenhauer averiguar as obras Ética a Eudemo e Ética a Nicômaco de Aristóteles na intenção de clarear as indicações feitas pelo filósofo alemão, de que a liberdade intelectual segue o voluntário e o involuntário de acordo com o pensamento [διάνοιαν] nos termos de Aristóteles.
SÓCRATES E ALCIBÍADES
Authors: Spinelli Miguel
Published: March 2023

Este artigo se ocupa em lançar luzes sobre o relacionamento amoroso entre Alcibíades e Sócrates. A análise se restringe basicamente ao Banquete de Platão, em particular aos termos do discurso de Alcibíades com os quais ele evidencia não só seus intentos, inquietudes e anseios como também os de Sócrates. O objetivo do artigo consiste em levantar esses intentos enquanto indícios da tese segundo a qual Platão, no Banquete, tende a restabelecer o antigo projeto espartano da educação cívica difundida entre os gregos.
FILOSOFIA E ARTE
Authors: Rosa Aline de Oliveira , Rasia Cossio Mauricio
Published: March 2023

Somos uma professora e um professor de filosofia que se perguntam como fazer com que nossas aulas tenham um significado para a vida de nossas(os) alunas, alunos e alunes. Significado este que aponte para a ideia de liberdade e autonomia, de expansão da consciência para uma compreensão e ação no mundo cada vez mais efetiva, seguindo a concepção de pedagogia libertadora de Paulo Freire e bell hooks. Para nós, a interação entre filosofia e arte tem muito a contribuir com esse processo. Não apenas porque, segundo Gilles Deleuze, o próprio trabalho com os conceitos filosóficos se assemelhe ao ritmo e andamento da música, mas porque, assim como na arte, o fazer filosófico não pode abrir mão das emoções para que possa ser realmente compreendido e significado em sua profundidade. Percebemos também que o trabalho com produtos artísticos, uma prática de ensino que Deleuze chama de Pop’Filosofia, faz com que a sala de aula possa se transformar num laboratório de sensações e pensamentos, trazendo a filosofia para os corpos e mentes de todas, todos e todes que fazem parte dessa experiência.
REPRESENTAÇÕES DE AUGUST DE SAINT-HILAIRE SOBRE OS GUARANI DOS SERTÕES MERIDIONAIS (1820-1821)
Authors: De Oliveira Jessica Caroline
Published: March 2023

Anais do “I Seminário de Ensino, Pesquisa e Extensão da Pós-Graduação em Filosofia da UNESAR”
A CRISE DAS DEMOCRACIAS CONTEMPORÂNEAS A PARTIR DO CONCEITO DE RETROTOPIA, DE ZYGMUNT BAUMAN
Authors: Bremmer Maia Alaércio
Published: March 2023

Anais do “I Seminário de Ensino, Pesquisa e Extensão da Pós-Graduação em Filosofia da UNESAR”
WITTGENSTEIN E A FILOSOFIA DA LÓGICA: OBSERVAÇÕES SOBRE AS PROPOSIÇÕES TAUTOLÓGICAS
Authors: Sousa Costa Leandro
Published: March 2023

Anais do “I Seminário de Ensino, Pesquisa e Extensão da Pós-Graduação em Filosofia da UNESAR”
A MEDITAÇÃO DA PRÁTICA EM EPICTETO
Authors: De Oliveira Rodrigues Antonio Carlos
Published: March 2023

Anais do “I Seminário de Ensino, Pesquisa e Extensão da Pós-Graduação em Filosofia da UNESAR”
Causal effects of gut microbiota on the risk of chronic kidney disease: a Mendelian randomization study
Authors: Luo Mingli , Cai Jiahao , Luo Shulu , Hong Xiaosi , Xu Lingxin , Lin Honghong , Chen Xiong , Fu Wen
Published: March 2023

Background

Previous studies have reported that gut microbiota is associated with an increased risk of chronic kidney disease (CKD) progression. However, whether gut microbiota has a causal effect on the development of CKD has not been revealed. Thus, we aimed to analyze the potential causal effect of gut microbiota on the risk of CKD using mendelian randomization (MR) study.

Materials and Methods

Independent single nucleotide polymorphisms closely associated with 196 gut bacterial taxa (N = 18340) were identified as instrumental variables. Two-sample MR was performed to evaluate the causal effect of gut microbiota on CKD (N = 480698), including inverse-variance-weighted (IVW) method, weighted median method, MR-Egger, mode-based estimation and MR-PRESSO. The robustness of the estimation was tested by a series of sensitivity analyses including Cochran’s Q test, MR-Egger intercept analysis, leave-one-out analysis and funnel plot. Statistical powers were also calculated.

Results

The genetically predicted higher abundance of order Desulfovibrionales was causally associated with an increased risk of CKD (odds ratio = 1.15, 95% confidence interval: 1.05-1.26; p = 0.0026). Besides, we also detected potential causalities between nine other taxa (Eubacterium eligens group, Desulfovibrionaceae, Ruminococcaceae UCG-002, Deltaproteobacteria, Lachnospiraceae UCG-010, Senegalimassilia, Peptostreptococcaceae, Alcaligenaceae and Ruminococcus torques group) and CKD (p < 0.05). No heterogeneity or pleiotropy was detected for significant estimates.

Conclusion

We found that Desulfovibrionales and nine other taxa are associated with CKD, thus confirming that gut microbiota plays an important role in the pathogenesis of CKD. Our work also provides new potential indicators and targets for screening and prevention of CKD.
Overexpression of the C4 protein of tomato yellow leaf curl Sardinia virus increases tomato resistance to powdery mildew
Authors: D’Errico Chiara , Forgia Marco , Pisani Marco , Pavan Stefano , Noris Emanuela , Matić Slavica
Published: March 2023

Powdery mildew (PM) is one of the most important diseases of greenhouse and field-grown tomatoes. Viruses can intervene beneficially on plant performance in coping with biotic and abiotic stresses. Tomato yellow leaf curl Sardinia virus (TYLCSV) has been reported recently to induce tolerance against drought stress in tomato, and its C4 protein acts as the main causal factor of tolerance. However, its role in response to biotic stresses is still unknown. In this study, transgenic tomato plants carrying the TYLCSV C4 protein were exposed to biotic stress following the inoculation with Oidium neolycopersici, the causal agent of tomato PM. Phytopathological, anatomic, molecular, and physiological parameters were evaluated in this plant pathosystem. Heterologous TYLCSV C4 expression increased the tolerance of transgenic tomato plants to PM, not only reducing symptom occurrence, but also counteracting conidia adhesion and secondary hyphae elongation. Pathogenesis-related gene expression and salicylic acid production were found to be higher in tomato transgenic plants able to cope with PM compared to infected wild-type tomato plants. Our study contributes to unraveling the mechanism leading to PM tolerance in TYLCSV C4-expressing tomato plants. In a larger context, the findings of TYLCSV C4 as a novel PM defense inducer could have important implications in deepening the mechanisms regulating the management of this kind of protein to both biotic and abiotic stresses.
Digitally measuring solar ultraviolet radiation in outdoor workers: A study protocol for establishing the use of electronic personal dosimeters in Portugal
Authors: Paulo Marília Silva , Symanzik Cara , Maia Melanie R. , Lapão Luís Velez , Carvalho Fernanda , Conneman Sven , Dias Jorge Barroso , Gobba Fabriziomaria , John Swen Malte , Loney Tom , Pinho Cristina , Rodrigues Ana , Strehl Claudine , Tenkate Thomas , Wittlich Marc , Modenese Alberto
Published: March 2023

Introduction

The rising incidence of skin cancer over the years has made it a significant public and occupational health issue. However, skin cancer is highly preventable, mainly through reduced exposure to solar ultraviolet radiation (UVR), which can be achieved by a variety of individual and collective protective measures and interventions. The relative risk associated with different patterns of exposure to solar UVR differs for the subtypes of keratinocyte cancers (KC). Specifically, whether the exposure is intermittent or continuous, and occurs in an occupational or leisure/recreational setting. The main aim of the study using this protocol is to contribute to raising public and policy awareness on solar UVR-inflicted occupational skin cancers in Lisbon. This will be achieved by performing direct measurements of the solar UVR dose received by outdoor workers using a digital platform. Results will likely contribute to further understanding the risk estimates for keratinocyte cancer estimations in this population.

Methods

A prospective observational study will be conducted in Lisbon, Portugal. Personal electronic dosimeters (GENESIS-UV system) integrated with a digital platform will be used to assess occupational solar UVR doses of gardeners, masons, and gravediggers of the municipality of Lisbon. Two hundred and ten outdoor workers will be selected to wear the dosimeter for 1 month each, between April and October during their daily working hours. A digital web-based platform that offers private access to information through dashboard visualization will provide information for the outdoor workers and facilitate communication with the participants.

Discussion

The expected results of the overall proposal comprise the occupational solar UVR doses, expressed in standard erythemal dose (SEDs) per day of outdoor work for 7 months. Study data will provide outdoor workers with information on their personal solar UVR exposure during their working hours and an estimate of their risk of developing skin cancer. It is expected that the occupational solar UVR doses of the outdoor workers in Portugal will be above the threshold of 1 to 1.33 SED/day, due to the latitude of Lisbon and the nature of the occupations. The results prospectively should flow into the design of adequate prevention campaigns for skin cancer in outdoor workers.
What is enlightened agriculture? A multi-normative approach to the nature and values of food production systems
Authors: Gunton Richard M.
Published: March 2023

The sustainable development of farming is an agenda with strong normative undertones, yet beyond the call to combine enhanced agricultural output with better environmental outcomes, this normativity is rarely unpacked or analysed with respect to different worldviews and value systems. The normative practices approach is a values-explicit framework for analysing the normativity of social practices; here it is applied to agriculture to provide a critique of sustainability. This helps to clarify the nature of farming and the breadth of sometimes incommensurable visions for its sustainable intensification. It also leads to a values-explicit concept of “enlightened agriculture”, defined as models for agricultural systems that explicitly realise aesthetic, jural and moral benefits, possibly at some cost to economic productivity. While any implementation of this qualitative definition will be worldview-dependent, it appears that land-sparing approaches and the promotion of biodiversity per se are unlikely to qualify as enlightened farming, but farming with concern for the wellbeing of humans and non-humans probably does. The recognition that normative worldviews direct social practices implies that there will be profound diversity among visions of good farming, which technical and political proposals ought to account for. In the face of accelerating global change, this diversity may provide both resilience and fertile grounds for new context-sensitive and community-led initiatives.
Development and validation of a predictive nomogram for lower extremity deep vein thrombosis dislodgement in orthopedic patients
Authors: Li Zongxuan , Liu Xiangdong , Li Liang , Cao Pengkai , Zhang Guanyu , Jiao Zhipeng , Wang Fengkai , Hao Qingchun , Li Yunsong , Zhang Yanrong
Published: March 2023

Objective

To analyze the risk factors of lower extremity deep venous thrombosis (DVT) detachment in orthopedic patients, and to establish a risk nomogram prediction model.

Methods

The clinical data of 334 patients with orthopedic DVT admitted to the Third Hospital of Hebei Medical University from January 2020 to July 2021 were retrospectively analyzed. General statistics included gender, age, BMI, thrombus detachment, inferior vena cava filter window type, filter implantation time, medical history, trauma history, operation, use of tourniquet, thrombectomy, anesthesia mode, anesthesia grade, operative position, blood loss during operation, blood transfusion, immobilization, use of anticoagulants, thrombus side, thrombus range, D-dimer content before filter implantation and during removal of inferior vena cava filter. Logistic regression was used to perform univariate and multivariate analysis on the possible factors of thrombosis detachment, screen out independent risk factors, establish a risk nomogram prediction model by variables, and internally verify the predictability and accuracy of the model.

Results

Binary logistic regression analysis showed that Short time window filter (OR = 5.401, 95% CI = 2.338–12.478), lower extremity operation (OR = 3.565, 95% CI = 1.553–8.184), use of tourniquet (OR = 3.871, 95% CI = 1.733–8.651), non-strict immobilization (OR = 3.207, 95% CI = 1.387–7.413), non-standardized anticoagulation (OR = 4.406, 95% CI = 1.868–10.390), distal deep vein thrombosis (OR = 2.212, 95% CI = 1.047–4.671) were independent risk factors for lower extremity DVT detachment in orthopedic patients (P < 0.05). Based on these six factors, a prediction model for the risk of lower extremity DVT detachment in orthopedic patients was established, and the risk prediction ability of the model was verified. The C-index of the nomogram model was 0.870 (95% CI: 0.822–0.919). The results indicate that the risk nomogram model has good accuracy in predicting the loss of deep venous thrombosis in orthopedic patients.

Conclusion

The nomogram risk prediction model based on six clinical factors, including filter window type, operation condition, tourniquet use, braking condition, anticoagulation condition, and thrombosis range, has good predictive performance.
Planet YouPorn: Pornography, Worlding, and Banal Globalization in Michel Houellebecq’s Work
Authors: Marcus Gustaf
Published: March 2023

This article studies mediated erotic content, especially pornography, as a form of worlding in Michel Houellebecq’s work. Whereas love creates a space of alterity, pornography paradoxically combines the most intimate spatiality of the body with ever-expanding technological systems and global forms of mediation. This short-circuiting of space points to a new sense of being in the world, which is studied in selected passages from the novels La Possibilité d’une île and Soumission, as well as in the essay “Prise de contrôle sur Numéris.” With reference to Ulrich Beck’s description of “banal cosmopolitanism,” I argue that otherness is either reduced to free-floating objects of consumption or to an experience of absence in these texts. Furthermore, this duality is refracted as two “reflexively” interwoven discourses or voices in the work. One is associated with prose and with the bringing of the world to the body of the subject, and the other with poetry and the dissolution of the body into the space of the world.
Identification of Emerging Multidrug-Resistant Neisseria gonorrhoeae Isolates against Five Major Antimicrobial Agent Options
Authors: Yakobi Sinethemba Hopewell , Pooe Ofentse Jacob
Published: March 2023

Antimicrobial drug resistance in Neisseria gonorrhoeae has been documented all over the world. However, the situation in Sub-Saharan Africa has received little attention. It is critical to establish diagnostics and extend surveillance in order to prevent the emergence of illnesses that are resistant to several treatments. Monitoring antimicrobial susceptibility is critically required in order to gather data that may be utilised to produce treatment recommendations that will result in effective therapy, a decrease in gonorrhoeae-related difficulties and transmission, and effective therapy. Government authorities may set research and preventive objectives, as well as treatment recommendations, using data from the Gonococcal Antimicrobial Surveillance Program (GISP). Local and state health authorities may use GISP data to make choices about the allocation of STI prevention services and resources, to guide preventative planning, and to disseminate information about the most successful treatment practices. Using molecular and culture approaches, we investigated the occurrence of antibiotic resistance in isolates from KwaZulu Natal, South Africa. The great majority of gonococcal isolates (48% showed absolute resistance to ciprofloxacin), with penicillin and tetracycline resistance rates of 14% each. Only one of the gonococcal isolates tested positive for azithromycin resistance, with a minimum inhibitory concentration (MIC) of 1.5 µg/mL. Ceftriaxone was effective against all gonococcal isolates tested.
Microstructure Characteristics and Mechanical Properties of Flash Butt Welded 590 MPa V-N Microalloyed Heavy-Duty Truck Wheel Steel
Authors: Gao Cairu , Cui Kaiyu , Lan Huifang , Liu Tao , Du Linxiu , Ma Yujiao , Guo Xinxin , Cui Chenshuo
Published: March 2023

This study reports the welded joint of a novel 590 MPa V-N microalloyed wheel steel on microstructure and mechanical properties after flash butt welding. The welding parameters were flash current 48°/582.0 A, upsetting current 44°/516.6 A, and workpiece clearance 1.5 mm. The evolution of microstructure in the welded joint occurred as follows: welding seam (ferrite side plate + acicular ferrite +martensite)→coarse-grained zone (acicular ferrite + granular bainite)→fine-grained zone (fine-grained ferrite + M/A island)→base metal (equiaxed ferrite + pearlite). The standard impact energy value of welding seam, coarse grain zone, fine grain zone, and base metal at −40 °C was 116, 128, 144, and 88 J, respectively. The mechanical property of the joint was excellent. The microstructure, the number of grain boundaries, and the dislocation density directly affected the strength and hardness of the joint. The increase of large angle grain boundaries and the decrease of effective grain size were beneficial to the improvement of toughness. The hot-rolled 590 MPa V-N microalloyed wheel steel had superior weldability.
Design and Properties of Natural Rosin-Based Phosphoester Functional Surfactants
Authors: Wang Maogong , Yang Xiaofang , Han Bing , Zhang Shifeng , Han Chunrui , Xia Changlei
Published: March 2023

As an important forestry biomass resource, rosin has a wide range of applications in medicine, adhesives, surfactants and other fields. Using natural dehydroabietic acid as a raw material, dehydroabietic acid-based phosphorus monoester (DPM) and diester (DPD) surfactants were designed and synthesized. The chemical structures and self-assembly properties were characterized by FT-IR, NMR and TEM, and the effects of pH on critical micelle concentration, γCMC, emulsifying properties, foam properties and micelle morphology were studied. The results showed that the CMC, γCMC value and aggregate morphology had certain pH responsiveness. The γCMC value under acidic conditions was smaller than γCMC under alkaline conditions, and the foaming performance and foam stability under acidic conditions were better than those under alkaline conditions. TEM micelle morphology studies have shown that DPM and DPD surfactants can self-assemble into rod-shaped and spherical micelle morphologies with a pH change in an aqueous solution. At the same pH, the foaming and emulsification properties of DPD were better than those of DPM. The best foaming and emulsification ability of DPD were 11.8 mL and 175 s, respectively. At the same time, the foaming ability of DPD is also affected by pH. DPD has excellent foaming properties in acidic conditions, but these disappeared in neutral conditions.
Multiscale Theoretical Study of Sulfur Dioxide (SO2) Adsorption in Metal–Organic Frameworks
Authors: Livas Charalampos G. , Raptis Dionysios , Tylianakis Emmanuel , Froudakis George E.
Published: March 2023

In the present work, we used DFT in order to study the interaction of SO2 with 41 strategically functionalized benzenes that can be incorporated in MOF linkers. The interaction energy of phenyl phosphonic acid (–PO3H2) with SO2 was determined to be the strongest (−10.1 kcal/mol), which is about 2.5 times greater than the binding energy with unfunctionalized benzene (−4.1 kcal/mol). To better understand the nature of SO2 interactions with functionalized benzenes, electron redistribution density maps of the relevant complexes with SO2 were created. In addition, three of the top performing functional groups were selected (–PO3H2, –CNH2NOH, –OSO3H) to modify the IRMOF-8 organic linker and calculate its SO2 adsorption capacity with Grand Canonical Monte Carlo (GCMC) simulations. Our results showed a great increase in the absolute volumetric uptake at low pressures, indicating that the suggested functionalization technique can be used to enhance the SO2 uptake capability not only in MOFs but in a variety of porous materials.
Biomimetic Guided Bi2WO6/Bi2O3 Vertical Heterojunction with Controllable Microstructure for Efficient Photocatalysis
Authors: Sun Yuanbo , Jia Ziang , Wan Ning , Feng Wei
Published: March 2023

To bridge the technical gap of heterojunction induction control in conventional semiconductor photocatalysts, a method of regulating the growth of heterojunctions utilizing biomimetic structures was designed to prepare a series of Bi2WO6/Bi2O3 vertical heterojunction nanocomposites for the disposal of environmentally hazardous tetracycline wastewater difficult to degrade by conventional microbial techniques. Porous Bi2O3 precursors with high-energy crystalline (110) dominant growth were produced using the sunflower straw bio-template technique (SSBT). Bi2WO6 with a (131) plane grew preferentially into 2.8 to 4 nm pieces on the (110) plane of Bi2O3, causing a significant density reduction between Bi2WO6 pieces and a dimensional decrease in the agglomerated Bi2WO6 spheres from 3 μm to 700 nm since Bi2WO6 grew on the structure of the biomimetic Bi2O3. The optimal 1:8 Bi2WO6/Bi2O3 coupling catalyst was obtained via adapting the ratio of the two semiconductors, and the coupling ratio of 1:8 minimized the adverse effects of the overgrowth of Bi2WO6 on degradation performance by securing the quantity of vertical heterojunctions. The material degradation reaction energy barrier and bandgap were significantly reduced by the presence of a large number of vertical heterojunction structures, resulting in a material with lower impedance and higher electron–hole separation efficiency; thus, the degradation efficiency of 1:8 Bi2WO6/Bi2O3 for tetracycline hydrochloride reached 99% within 60 min. In conclusion, this study not only successfully synthesized a novel photocatalyst with potential applications in water pollution remediation but also introduced a pioneering approach for semiconductor-driven synthesis.
Gliclazide MV: Proven Efficacy and Safety
Authors:   Russian Gerontology Research and Clinical Centre of N.I. Pirogov Russian National Research Medical University, Ivannikova E.V. , Dudinskaya E.N.
Published: March 2023

To date, sulfonylurea derivatives occupy a leading position in the structure of diabetes mellitus therapy. The article discusses the effectiveness and safety of the use of sulfonylurea derivatives in order to compensate for carbohydrate metabolism, including in comparison with other classes of hypoglycemic drugs. Special emphasis is placed on cardiovascular safety.
Analysis of Fragmentation QRS Complex and Early Repolarization Pattern in Patients with Myocardial Inflammatory Changes
Authors:   V.A. Almazov National Medical Research Centre, Gordeeva M.S. , Serdiukova I.A. , Krasichkov A.S. , Parmon E.V. ,   Saint Petersburg State Electrotechnical University LETI named after V.I. Ulyanov (Lenin)
Published: March 2023

Inflammatory changes in the myocardium create the prerequisites for the electrical instability of the myocardium, which can affect the ECG. It is promising to study relatively new electrocardiographic patterns: fragmentation of QRS (FQRS) and premature ventricular beats (FPVB) and early repolarization pattern (ERP) to improve the screening of patients with suspected myocarditis. Aim. To study FQRS, FPVB and ERP in patients with inflammatory changes in the myocardium. Material and methods. The study included 46 patients (78.3% male, 21.7% women) with suspected myocarditis. Age: median 47.5, quartile 37; 56.5. In all patients, the anamnesis, results of ECG, echocardiography, cardiac magnetic resonance imaging and endomyocardial biopsy were analyzed. Results. The patients were divided into three groups: the 1st – 20 patients with inflammatory and fibrotic changes in the myocardium, the 2nd – 20 patients with myocardial fibrosis without inflammatory, the 3rd – 6 patients without structural changes in the myocardium. FQRS in the 1st group was detected in 35% of the examined, in the 2nd – in 25%, in the 3rd – not registered. FPVB in the 1st group was determined in 55% of the examined, in the 2nd – in 30%, in the 3rd – in 33.3%. ERP in the 1st group was registered in 30% of the examined, in the 2nd group it was not detected, in the 3rd group – in 16.7%. FPVB and ERP were informative for the detection of inflammation (sensitivity – 57.9 and 85% respectively, specificity – 69.2 and 53.8% respectively). For the detection of fibrosis, FPVB proved to be the most informative (sensitivity – 80.0%, specificity – 59.1%). Conclusions. FQRS, FPVB, and ERP are significant ECG-markers for detecting both inflammatory changes in the myocardium and fibrosis. The use of these ECG-markers in routine clinical practice may have an impact on further management of patients with suspected myocarditis.
Diagnostic Markers of Heart Damage in Patients with a Moderate Form of New Coronavirus Infection
Authors:   Central Research Institute of Epidemiology of Rospotrebnadzor, Ageykin A.V. , Usenko D.V. , Gorelov A.V. , Melnikov V.L. , Zvonova K.A. ,   Penza State University,   Medical Сenter ‘Penza-Med’
Published: March 2023

The results of numerous randomized clinical trials indicate the relationship of a new coronavirus infection (NCI) with the development of acute myocardial injury (AMI). Of great importance in the defeat of the heart belongs to the change in the cytokine and chemokine status, which determines the inflammatory potential. The aim of this work was a comprehensive assessment of clinical and laboratory indicators of the state of the heart in a new coronavirus infection and the determination of immunopathogenetic mechanisms of myocardial damage. 180 patients hospitalized with a diagnosis of «coronavirus infection COVID-19, virus identified (U07.1), moderate form» were examined. Risk factors, levels of cytokines and chemokines (IFN-α, IL-6, IL-17, MIP-1b), markers of cardiac damage/dysfunction (troponin I and FAFA, NTproBNP), and antimyocardial IgG antibodies were assessed. Statistical processing was carried out using the Microsoft Office package (Microsoft Excel), as well as the statistical package STATISTICA 9.0. The Shapiro-Wilk W test was used to check the normality of the distribution. Differences were considered significant at p ≤ 0.05, unreliable at p ≥ 0.05. It has been established that in the acute period, 45% of patients have an increase in troponin I values. They also have significantly higher levels of IL-6, IL-17 and MIP-1b against the background of inhibition of IFN-α production. In the acute period, a third of patients have antimyocardial antibodies, which are detected significantly more often and in higher titers in patients with AMI. The presence of a direct correlation between the level of antimyocardial antibodies and an increase in the amount of CRP, MIP-1b and IL-17 was established. The most significant risk factors for the development of myocardial damage in NCI are the presence of a burdened history of cardiovascular diseases, an increased body mass index, and diabetes mellitus. Thus, high levels of CRP, MIP-1b IL-17, antimyocardial antibodies, with a continuing deficiency without a tendency to restore the level of IFN-α, in the presence of the above risk factors, are diagnostically significant markers of AMI in patients with moderate NCI.
Global trends of transformation of world financial architecture
Authors:   Vasyl' Stus Donetsk National University, Savchenko Maryna , Bratchuk Ulyana ,   Vasyl' Stus Donetsk National University
Published: March 2023

The article is devoted to the determination of global trends of the world financial architecture transformation. The views of scientists on the term "world financial architecture" were considered, the institutional and economic aspect of this term was studied in the context of financial globalization. It was determined that the global economy is at the stage of significant financial and currency crises. This is accompanied by the weakness of the financial sector in emerging markets, the increase in the number of offshore financial centres, the limitation of the international institutions’ ability to provide financial support to developing countries, etc. Reasonably, the global financial architecture and the need for its transformational shifts directly depends on the trends in the world financial market and the stability of the world economy, which has been experiencing crisis phenomena in recent years. The global economy is experiencing persistently high inflation, the highest in last decade, amid heightened economic and geopolitical uncertainty and disruptions in energy and commodity markets caused by the COVID-19 pandemic and Russia's ongoing war in Ukraine. An analysis of world commodity price trends is provided. It determines the high inflation of consumer prices, that is especially high in developing countries. It was determined that the national regulators of developed countries apply a stricter monetary policy and curtail measures to support the economy. It was concluded that the situation on the world commodity markets, high inflation, the increase in the cost of borrowing and the weaker growth of the leading economies significantly undermine the growth prospects of developing countries with emerging markets. This group of countries is in a more unfavourable condition than others and undermines the global stability of the world financial architecture. It is necessary to carry out stabilization measures if inflation indicators will grow not only in developing countries, but also in developed countries, whose destabilizing effect on the global economic system will be more impressive.
Improving the organization of upgraiding qualification for employees of state employment service
Authors:   Ukrainian State Employment Service Training Institute, Savchenko V.
Published: March 2023

Relevance: the article is devoted to improving the organization of upgraiding qualification for employees of the state employment service in the context of the strengthening of the economic crisis in Ukraine due to the introduction of martial law, the pandemic of new strains of the COVID-19 coronavirus and the growth of mass unemployment. Overcoming these crisis phenomena is of great importance, requiring the development and implementation of anti-crisis strategies and active policies in the field of public employment, the transformation of management and the improvement of the level of qualifications for employees of employment centers. Aim: substantiation of measures to achieve greater social and economic efficiency from improving the qualifications of employees for the state employment service thanks to the introduction of innovative forms and methods of training trainees. Object of the research: processes of organization for training of employees according to professional training programs and short-term thematic training, internship of trainees. Methods: general philosophical, general scientific and special research methods, which include methods of system analysis. Results: The analysis of the system of upgraiding qualifications for employees of the state employment service showed that the crisis economic situation made it difficult to implement the plan for improving the qualifications of employees, and worsened the quality and scope of their training. In order to increase the efficiency of upgraiding qualification improvement of the employees for the state employment service, the author proposed an anticrisis strategy of improving their qualification in accordance with the modern conditions of the market economy in the conditions for martial law. Reasoned measures for planning the amount of training of trainees based on the development of a balance sheet calculation of the additional needs of the state employment service in the upgraiding qualification of employees. Indirect methods of evaluating the effectiveness of upgraiding qualification of employment center employees have been determined. The study revealed the reasons that led to the shortage of funds for improving the qualifications of employees. The conducted research made it possible to propose improvements in the forms and methods of staff training identified additional sources of funding to ensure the quality upgraiding qualification of trainees. Among the additional sources of funding for upgraiding qualification of the staff of the state employment service, special attention to the introduction of individual training accounts for employees in Ukraine.
Liliia KORNILIEVA: ABOUT THE AUTHOR
Authors: TUCHYNA Nataliia
Published: March 2023

Liliia Kornilieva, DSc (Philology), is a professor at the H.S.Skovoroda Kharkiv
National Pedagogical University teaching Cross-Cultural Studies, Practice of
Translation and Literary Studies. She has over 50 publications, two monographs
and three textbooks included, a number of articles and teaching guides. She is also a
prolific author of popular books.
During 2022 alone, she published six books for children. Her book “Mysteries
of Kharkiv Covered with Snow”, published as early as January 2022, gives us the last
glimpse of the pre-war city. The author focuses on traditions of celebrating Christmas
and New Year`s Day in Kharkiv. Liliia Kornilieva reveals the symbolic meaning of
beautiful Christmas installations, decorations, Ukrainian souvenirs, confectionary
and merchandise. Many local traditions, toponyms and realia are not only mentioned
but also fully explained.
НЕКРОТИЗУЮЧИЙ ПАРОДОНТИТ У ХВОРИХ НА ВІЛ-ІНФЕКЦІЮ
Authors: Чумакова Ю.Г. , Заградська О.Л.
Published: March 2023

У новій Міжнародній класифікації захворювань і станів тканин пародонта і периімплантних тканин (AAP&EFP, Chicago, 2017) некротизуючі захворювання пародонта, а саме некротизуючий гінгівіт, некротизуючий пародонтит та некротизуючий стоматит, внесені окремим підрозділом до II групи – «Пародонтит». На даний час термін «виразково-некротичний пародонтит» виключений. Виділення некротизуючих захворювань пародонта в окрему групу пов'язане з тим, що вони значно відрізняються від інших уражень пародонта за етіологією, патогенезом та клінічними проявами. Основною причиною розвитку некротизуючих захворювань пародонта є імунодефіцитні стани, викликані наявністю у пацієнтів хронічних бактеріальних, грибкових і вірусних інфекцій, у тому числі і ВІЛ-інфекції. Некротизуючі захворювання пародонта віднесені до першої групи ВІЛ-асоційованих проявів у ротовій порожнині, які виникають на III-IV клінічніх стадіях ВІЛ-інфекції. Найбільш тяжким з них є некротизуючий пародонтит, який виникає у хворих на ВІЛ/СНІД при кількості CD4-лімфоцитів менше 200 клітин/мкл. Мета дослідження. Оцінка ефективності лікування ВІЛ-позитивного пацієнта з некротизуючим пародонтитом на тлі застосування антиретровірусної терапії. Результати. В роботі продемонстровано клінічний випадок первинного розпізнавання ВІЛ-інфекції на стоматологічному прийомі у пацієнта К., 21 рік, по клінічним симптомам некротизуючого пародонтиту. Представлені результати надання первинної стоматологічної допомоги хворому (2010 р.), а також подальшого лікування пародонтиту і ортопедичної реабілітації (через 3 роки) в умовах застосування антиретровірусної терапії ВІЛ-інфекції. Висновки. При виявленні клінічних симптомів некротизуючого пародонтиту необхідне обов'язкове обстеження пацієнта на ВІЛ-інфікування. Планове стоматологічне лікування, інвазивні процедури та протезування зубних рядів у хворих на ВІЛ/СНІД можна проводити після покращення загального стану пацієнта за результатами антиретровірусної терапії.
Developing countries and Sustainability
Authors: Kadiu Arjana , Szabó Zoltán
Published: March 2023

Countries all over the world aim for stability and better quality of life. They deal every day with issues like income inequality, uneven distribution of wealth, irresponsible production and consumption, or draining of natural resources. Many of them are embracing sustainable development, aiming to meet their citizen’s needs, without compromising the capacity of future generations to meet their own needs. Meanwhile, in a developing country, with a lower GDP, not well-balanced economic sectors, difficult access to quality healthcare and education, and a lack of technology and infrastructure, the above-mentioned issues are intensified. These countries don’t seem to be in the most favorable position to grow sustainably. However, a safe society and economy for all generations are equally important in both developed and developing countries. Primary and secondary research used in this study aims to highlight the situation in Albania and how the country approaches the goals of sustainable development. Environmental, economic, and social issues are analyzed, in order to understand Albania’s possibilities to achieve sustainable development. The study aims to point out the urgent necessity of a common framework addressing the principles of a green economy and offer recommendations on how to design one.
Osmotic Stress Enhances Antimicrobial Activity of in Vitro Grown Microshoots of Ochradenus Baccatus Delile Against Selected microbes
Authors: Darwish Maysaa M. , Shibli Rida A. , Al-Qadiri Hamzah M. , Tahtamouni Reham W. , Al-Saleh Majd M. , Abu Mallouh Saida , Al Qudah Tamara S.
Published: March 2023

Ochradenus baccatus Delile is a wild medicinal plant that produces several natural compounds with medicinal benefits. In this study, microshoots of Ochradenus baccatus were exposed to osmotic stress conditions consisting of Murashige and Skoog solid media (MS) media that containing different osmotic agents (sugar types) at a range of concentrations (including 0.1, 0.2, 0.3 or 0.4 M). The purpose was to test their effects on microshoots’ growth and antimicrobial activities against selected strains of bacteria and one strain of fungi. It has been found that growth parameters (including shoot length and proliferation) of Ochradenus baccatus microshoots declined with increasing sugar concentration in the media, but at the highest concentrations of 0.4M mannitol, the micorshoots could not survive.  Generally, aqueous extracts of the stressed microshoots were more effective against the tested microbial strains than the methanolic extracts in most experiments. Staphylococcus aureus was found to be the most affected microbe to both extract types. Also, exposing the microshoots to osmotic stress had improved antimicrobial powers in both extracts types. Aqueous extract of microshoots that pre-grew in media with (0.4 M sucrose) was interestingly found to inhibit growth of Staphylococcus aureus and Candida albicans with minimal inhibitory concentration (MIC) values of (0.195, 0.78 mg/ml). These values were similar to those obtained from the antibiotic treatments. Other biotechnological techniques like genetic transformation are suggested to be also used for production of elite strains of Ochradenus baccatus with super antimicrobial potential.
Ricerca e conservazione sul patrimonio costruito: Casina Spinelli ad Acerra
Authors: Fiorillo Raffaela
Published: March 2023

The built heritage in Italy holds enormous value for the community and cultural assets such as monuments and buildings, places of worship and fortifications, were often considered unrelated to their surroundings despite their great interest. Large towns, small villages and the countryside depend on each other and are in balance with each other, so all rural and cultural landscapes represent a rich heritage composed of various types of spaces characterised by great diversity. Case study is the Casina Spinelli located in the Calabricito forest, in the territory of the city of Acerra. The contribution attempts to demonstrate how the adoption of aerial survey methodologies and photometric restitution allow, through and with the help of historical research, an interesting and renewed tourist archive of the territorial heritage.
Amatrice avant Amatrice : Une méthode de travail pour l'étude, la documentation et la conservation d'un village perdu
Authors: Lucchetti Simone
Published: March 2023

A shocking event such as the one experienced by the population of central Italy in 2016 highlights two problems that afflict the national heritage: the fragility of historic villages and the conservation of the historical-artistic heritage of these cultural centres. This paper intends to propose an applicative method to address the problem of the documentation and conservation of the material and intangible characteristics of the historic centre of Amatrice following an earthquake that de facto cancelled almost all the material components and therefore prevents a campaign of traditional data acquisition. The applied methodology is based on the complementarity between the analysis of unpublished historical photographic material and the digital reconstruction of each building in the city through the aid of Google Street, creating an integration between digital restitution tools, social media as iconographic sources and the contextual architectural reading of the few building fragments still in situ.
Nuove tecnologie e sostenibilità: dal rilievo alla comunicazione per il Museo di Casa Romei di Ferrara, città Patrimonio UNESCO
Authors: Mei Gianmarco , Boscaro Cristian , Costantini Stefano , Incerti Manuela
Published: March 2023

The paper, taking the Museum of Casa Romei in Ferrara - an UNESCO heritage city - as a case study, explores some new technologies, ranging from surveying to digital communication and investigates their potentialities in improving the sustainability of cultural heritage. The work pursues the dual value of analyzing new tools and providing research products useful for the enhancement of the specific site, favoring the dissemination of consolidated tourist flows from the major monuments of Ferrara to the more peripheral historical urban fabric. Through the theme of analysis, documentation and archiving of architecture and its context, the research - addressing specific themes of integrated and multi-scale survey, 3D processing, 2D drawing, interactive data storage - examines the use of digital technologies for multi-level dissemination of the cultural assets and their possibilities as tools for accessibility and inclusivity.
أثر البيئة السياسية في شعر شعراء الحلة في القرن السابع الهجري
Authors: مهدي عدنان كاظم , إبراهيم فراس نوري
Published: March 2023

انصرف كثير من الباحثين عن دراسة الادب العربي في المرحلة التي تلت سقوط بغداد ، متذرعين بعقم الأدب ، وفقر الشعراء في اللحاق بمن سبقهم، وقد ترسخ هذا المفهوم لعدة قرون وإلى يومنا هذا ، فأطلقوا عليه سماتٍ ونعوتاً كثيرة وهي في الأغلب كانت إجحافاً بحق أدباء هذه الحقبة وشعرائها  . والحقيقة الأكيدة أن شعر هذه الحقبة لايخلو من إبداع فكري وخلق فني .مما لاشك فيه أن الأحداث السياسية التي مرت بها الأمة الإسلامية تركت أثرها في الحياة الأدبية عموماً والشعر خصوصاً . وقد وقع اختيارنا على شعراء مدينة الحلة لعدة أسباب منها قربها من الأحداث السياسية التي عصفت بالعراق آنذاك ، ولأن هذه المدينة أصبحت قبلة المتعلمين ومركز الحضارة بعد سقوط بغداد ، فبزّت أقرانها من المدن الإسلامية ؛ فتخرج فيها العلماء الأعلام والشعراء الكبار وهذا البحث جاء ليسلط الضوء ويكشف عن أهم شعراء الحلة في القرن السابع الهجري ممن كانوا من أبناء الحلة أو ولدوا فيها . وقد حاولنا استقراء الأثر السياسي في شعرهم في مدة شابها كثير من الشبهات والملابسات .والبحث يتكون من مقدمة وأربعة مباحث هي : المدح السياسي، والرثاء السياسي ، والهجاء السياسي ،وشعر الوقائع السياسية ، يتلوها خاتمة بأهم النتائج وثبت لمصادر ومراجع البحث .