bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between Anemia and Academic Performance in Chinese Primary School Students: Evidence from a Large National Survey
Authors: Hu Yisong , Mao Yanxin , Wang Weidong
Published: January 2024

Anemia is a global public health problem, especially common among children in developing countries, which affects their physical and mental health development. However, there is currently a lack of research on the relationship between anemia and academic performance. The objective of this study was to explore the association between anemia and academic performance, and the possible factors mediating this association among Chinese children. The data for this study came from the baseline survey of the Chinese Education Panel Survey Elementary School Cohort. The cohort was conducted from September 2018 to June 2019 in 160 elementary schools, covering 20 provinces and 40 counties/districts throughout China. Paper‐based questionnaires were used, completed by 4th grade students, parents, head teachers, main teachers, and principals. The data used included questionnaire responses, physical measurements, and academic performance of 17,695 students. Based on students’ hemoglobin levels and school altitude data, we grouped them into anemia and nonanemia categories using WHO criteria. The anemia group had 1,154 individuals, while the nonanemia group had 16,541 individuals. An ordinary least squares regression and mediation effect analysis were conducted. Our findings found the prevalence of anemia was 6.52% among Chinese Grade 4 students. Students without anemia had a higher average test score for three academic subjects than students with anemia (P < 0.001); their test scores for Chinese, Mathematics, and English were also higher (P < 0.05). Multivariate regression analysis showed a negative association between anemia and average test scores as well as individual test scores for the three subjects. Mediation analysis found that anemia affected academic performance directly (P < 0.05), and indirectly by decreasing the cognition score (P < 0.05). The indirect effect was 19.9% of the total effect. Findings highlighted anemia affected academic performance both directly and indirectly. Nutrition‐related interventions should be implemented to prevent a decrease in academic performance among students with anemia.
Tirofiban on Fully Recanalized Stroke with Thrombectomy: A Propensity Score Matching Analysis
Authors: Guo Wenting , Li Ning , Xu Jiali , Hu Wenbo , Ma Jin , Li Sijie , Ren Changhong , Chen Jian , Duan Jiangang , Ma Qingfeng , Song Haiqing , Zhao Wenbo , Ji Xunming
Published: January 2024

Background and Objective. Approximately 50% of acute ischemic stroke (AIS) patients who achieve complete recanalization after endovascular therapy (EVT) experience unfavorable outcomes that are potentially partially attributed to incomplete microvascular reperfusion, which can possibly be improved by antiplatelet treatment. This study aimed to evaluate the effect of periprocedural tirofiban on AIS patients who achieved complete recanalization with EVT. Methods. Anterior circulation large‐vessel occlusion stroke patients who achieved complete recanalization after EVT were retrospectively analyzed. Patients were dichotomized into tirofiban and nontirofiban groups and compared. Propensity score matching (PSM) was used to balance baseline confounders. 3‐month functional independence (modified Rankin scale: 0–2), any intracranial hemorrhage (ICH), symptomatic ICH (sICH), arterial reocclusion, in‐hospital mortality, and 3‐month mortality were evaluated. Results. This study included 303 patients with 118 and 185 in the nontirofiban and tirofiban groups, respectively. After PSM, 85 couples with balanced baseline characteristics were generated. 49 (57.6%) and 36 patients (42.4%) in the tirofiban and nontirofiban groups achieved functional independence at 3 months with a significant difference (risk ratio: 1.361, 95% confidence interval: 1.001–1.852, P = 0.046). However, there was no significant difference between the tirofiban and nontirofiban groups in terms of the other outcomes (all P > 0.05). Conclusions. In anterior circulation, large‐vessel occlusion AIS patients who achieved complete recanalization with EVT, periprocedural tirofiban may improve the functional outcomes and does not appear to increase the rate of ICH and sICH.
Investigating the Fish Assemblages of the Neosho River System
Authors: Rasset Ethan J. , Kim Hae H. , Neely Ben C. , Phelps Quinton E.
Published: January 2024

Barrier presence in river systems has been demonstrated to impair fish assemblages. Low head dams specifically are frequently occurring barriers in riverine environments. Well-supported impacts of these structures on fishes include diminished movement, reproduction, and habitat availability. Longitudinal patterns in riverine fish assemblages have long been researched to ascertain dynamics and display interactions. The need for research becomes more critical when factoring in impacts of barriers and detrimental invasive species. Knowledge of fish assemblages can inform fisheries biologists and aid in improved management practices for recreational and ecologically important species, as well as invasive species. The Neosho River system in Kansas has 14 barriers present. Little fisheries sampling has been done in the Kansas portion of this river system from the John Redmond Dam to the Oklahoma border; therefore, sampling was conducted to inform questions posed about the fish assemblages. We sought to document the fish assemblages of the system in Kansas and examine for assemblage composition distinctions by geographic region along a longitudinal gradient. The fish assemblage dataset from this research generated a wealth of knowledge on sportfish infiltration from reservoirs, imperiled fishes, and apparent impacts from low-head dams. Information from this study will aid in future management and direct new research investigating imperiled fishes.
The Correlation between Intraorifice Distance and the Anatomical Characteristics of the Second Mesiobuccal Canal of Maxillary Molars: A CBCT Study
Authors: Perondi Isabella , Taschieri Silvio , Baruffaldi Martino , Fornara Roberto , Francetti Luca , Corbella Stefano
Published: January 2024

Introduction. Missing anatomy is one of the main causes of endodontic failures, and accurate knowledge of teeth anatomy is a prerequisite for adequate root canal treatment. The aim of the present cone beam computed tomography (CBCT) study was to describe the anatomical characteristics of the mesiobuccal (MB) root canals of maxillary molars and to understand if a correlation exists between the position of the canal orifices and the anatomical features of the root. Methods. For the purposes of the study, a total of 100 CBCT scans of maxillary molars with two MB canals were selected and studied. The features of root canal anatomy of the MB root of the same teeth were analyzed and recorded (root length, confluence, and Vertucci classification). The distance between MB1 and MB2 orifices and the palatal orifice were recorded, as well as the distance between the orifices and the line joining the palatal orifice and the others. A statistical analysis was performed by providing descriptive measures, the measure of the correlation between different parameters, and the influence of some of these measures on the presence of a confluence between MB1 and MB2. Results. It resulted that the most frequent configuration is type II Vertucci. The length measured on the sagittal plane was significantly correlated to the presence of a confluence in the MB root. When the root length was higher than 14.56 mm, the confluence is three times more frequent than when the length is lower (OR = 3.635). The area under the curve (AUC) of the receiver operator characteristic (ROC) curve for length on the sagittal plane was 0.632 (P = 0.036). Conclusions. The presence of a confluence between the MB canals of maxillary molars is correlated to the length of the root that could be measured on the sagittal plane and to the distance between the canal orifices. The relative position of the root canal orifices in relation to anatomic landmarks needs to be further explored.
Job Resources and Core Self-Evaluation as Predictors of Nurse Engagement and Patient-Safety Outcomes: A Longitudinal Study
Authors: Luo Dan , Yang Xuening , Bai Yamei , Song Yulei , Chen Baoyun , Liu Ya
Published: January 2024

Background. Work engagement and patient-safety outcomes in nursing practice are critically significant. However, most previous studies evaluating antecedents of work engagement and patient-safety outcomes have used cross-sectional designs. Aims. To investigate the effects of job resources (organizational support and leader empowerment) and core self-evaluation on nurses’ work engagement and patient-safety outcomes. Methods. This longitudinal study surveyed 2,618 registered nurses from 17 public hospitals in XuZhou, China. Participants completed self-report questionnaires on organizational support, leader empowerment, and core self-evaluation at baseline. Work engagement and patient-safety outcomes were collected 18 months after the baseline. The mixed linear regression and Johnson–Neyman statistical analysis were used to analyze data. Results. Organizational support was an outsize predictor of nurses’ work engagement, followed by core self-evaluation and leader empowerment. Organizational support and core self-evaluation were equally crucial for predicting patient-safety outcomes. Moreover, the positive impact of leader empowerment on patient-safety outcomes became significant when the core self-evaluation score was below 51. Conclusions. This study demonstrated that organizational support, leader empowerment, and core self-evaluation are important determinants of nurses’ work engagement and patient-safety outcomes. Implications for Nursing Management. Hospital managers and nurse leaders should consider providing multiple supports to motivate staff nurses to engage in work. When nurses’ core self-evaluation is low, empowering training for nurse leaders should be essential to reduce adverse patient events.
Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety
Authors: Zekibakhsh Mohammadi Nassim , Kianimoghadam Amir Sam , Mikaeili Niloofar , Asgharian Seyedeh Samaneh , Jafari Mahdieh , Masjedi-Arani Abbas
Published: January 2024

Sleep disorders and fatigue represent prominent symptoms frequently experienced by individuals with multiple sclerosis (MS). Some psychological factors such as depression, stress, and anxiety seem to have a relationship with such problems. This study aimed to examine the role of depression, stress, and anxiety in predicting sleep disorders and fatigue among patients with MS. Employing a cross-sectional descriptive-correlational design, the study involved a sample size of 252 participants selected through purposive sampling based on inclusion and exclusion criteria. We utilized a demographic information questionnaire along with the Mini-Sleep Questionnaire (MSQ), Fatigue Severity Scale (FSS), and Depression, Anxiety, and Stress Scale (DASS-21) to collect data and analyzed them applying SPSS22, incorporating statistical measures including Pearson correlation and regression. The results of the Pearson correlation coefficient showed that sleep disorders had a positive and significant relationship with depression (r = 0.56; P<0.001), stress (r = 0.40; P<0.001), and anxiety (r = 0.52; P<0.001). There was no significant relationship between age and the development of sleep disorders in total score (r = −0.001; P<0.985), but age had a relationship with insomnia (r = −0.146; P<0.021) and oversleeping (r = 0.153; P<0.015). Age and fatigue did not have a significant relationship as well (r = −0.044; P<0.941). In addition, fatigue had a positive and significant relationship with depression (r = 0.52; P<0.001), stress (r = 0.48; P<0.001), and anxiety (r = 0.54; P<0.001). The results of the regression analysis also showed that depression, stress, and anxiety predict 0.37% of the total variance of sleep disorders (F = 48.34; P<0.001) and 0.35% of the total variance of fatigue (F = 44.64; P<0.001). Our findings suggest that depression, stress, and anxiety play a significant role in predicting sleep disorders and fatigue among patients with MS. This study has been reported in accordance with the TREND checklist for nonrandomized trials.
FIGURE 5 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: January 2024

Differential gene expression profile, consolidated gene set enrichment, and network analyses. A, Differences in gene expression are shown in volcano plot format, where the X-axis denotes the log2-transformed fold-change and the Y-axis denotes the –log10-transformed P value. The log2 fold-change was calculated as Cas9-p15 control cell fold-change/MELK KO MDA-MB-231 cell fold-change, resulting in positive values for genes overexpressed in the WT condition and negative values for genes overexpressed in the KO condition. The nominal P value threshold at 5% is indicated by a dashed blue horizontal line. The 10 most differentially expressed genes by P value are labeled using their gene symbol. B, Differences in the hallmark enrichment pattern are shown in a modified volcano plot format, where the X-axis denotes the normalized enrichment score and the Y-axis denotes the –log10-transformed P value. The normalized enrichment score was calculated as Cas9-p15 control cell score/MELK KO MDA-MB-231 cell score, resulting in positive values for hallmarks enriched in the WT condition and negative values for hallmarks enriched in the KO condition, as indicated at the top of the plot. The nominal P value threshold at 5% is indicated by a dashed blue horizontal line. Significant hallmarks are labeled using their gene set name. C, Pathway enrichment profile of the MELK-centered PPI network. In the left part of the plot, significantly enriched pathways, listed along the Y-axis, are represented in dot plot format; the X-axis represents the –log10-transformed P value; and the size of the dots reflects the number of pathway genes contained in the network. To the right of the dot plot, overlaps between enriched pathways and three gene sets defined after analyzing the MELK-centered protein–protein interaction network are indicated in heat map format. The gene sets of interest are indicated in the X-axis underneath the heat map, where dark blue denotes the presence of pathway genes and light blue denotes the absence of pathway genes in these gene sets.
FIGURE 2 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: January 2024

Effect of MELK knockdown or overexpression on proliferation, motility, EMT, and CSC properties in TNBC cells. Effect of MELK knockdown or KO (A) or overexpression (B) on proliferation and anchorage-independent growth of TNBC cells. HCC70 and BT-549 cells (A, bottom left) were treated with two different siMELK sequences for 48 hours. MELK expression was then determined using Western blot analysis (top), and cell viability was determined using trypan blue exclusion assay (bottom left). In MELK KO MDA-MB-231 cells (A, bottom right), anchorage-independent growth was determined using soft-agar assay at week 3 following incubation. β-Actin was used as a loading control for Western blot analysis. SUM149 and SUM159 cells (B) were transfected with plasmids encoding WT MELK gene or KD MELK gene and cultured for 48 hours. MELK expression was then determined using Western blot analysis (top), and cell growth was determined using anchorage-independent growth assay (bottom). β-Actin was used as a loading control for Western blot analysis. Effect of MELK knockdown (C) or overexpression (D) on migration and invasion of TNBC cells. Cells were transfected with two different siMELK sequences for 72 hours or plasmids encoding WT MELK gene or KD MELK gene for 48 hours and then assayed for migration and invasion. E, Effect of MELK knockdown on expression of EMT epithelial and mesenchymal markers in TNBC cells. Cells were treated with two different siMELK sequences for 48 hours, and then MELK expression was determined using Western blot analysis. α-Tubulin was used as a loading control. Effect of knockdown or KO (F) or overexpression (G) of MELK on mammosphere formation in TNBC cells. Cells were transfected with two different siMELK sequences or plasmids encoding WT MELK gene or KD MELK gene and 48 hours later were seeded for mammosphere formation. MELK KO clones were cultured for 7 days and then analyzed for mammosphere formation. H, Effect of MELK knockdown on CD44+/CD24− and ALDH1+ subpopulations in TNBC cells. Cells were treated with two different siMELK sequences and 48 hours later subjected to flow cytometry analysis. In A and F, P15 indicates Cas9-p15 control cells; C3, MELK KO C3 clones; and C28, MELK KO C28 clones. In A–D, G, and F, data are presented as mean ± standard deviation. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
Supplemental Table 1 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Supplementary Table 1. Representativeness of Study Participants
Supplemental Methods from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Supplemental Methods
FIGURE 3 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Swimmer plots of patients by course of treatment and dose reduction of E7389-LF (A) and lines of subsequent therapies received during survival follow-up (B). Patients could continue to receive study drugs beyond disease progression if they had investigator-assessed clinical benefit and were tolerating study drugs. This figure includes data from beyond disease progression. #L, line of treatment number; AE, adverse event; BSC, best supportive care; PD, progressive disease; PR, partial response.
HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation
Authors: Nishida Hiroko , Suzuki Reiko , Nakajima Kiyora , Hayashi Mutsumi , Morimoto Chikao , Yamada Taketo
Published: January 2024

CD26 is ubiquitously and intensely expressed in osteoclasts in patients with multiple myeloma, whereas its expression in plasma cells of patients with multiple myeloma is heterogeneous because of its cellular diversity, immune escape, and disease progression. Decreased expression levels of CD26 in myeloma cells constitute one of the mechanisms underlying resistance to humanized anti-CD26 mAb therapy in multiple myeloma. In the current study, we show that histone deacetylase inhibition (HDACi) with broad or class-specific inhibitors involves the induction of CD26 expression on CD26neg myeloma cells both transcriptionally and translationally. Furthermore, dipeptidyl peptidase Ⅳ (DPPⅣ) enzymatic activity was concomitantly enhanced in myeloma cells. Combined treatment with HDACi plus CD26mAb synergistically facilitated lysis of CD26neg myeloma cells not only by antibody-dependent cellular cytotoxicity but also by the direct effects of mAb. Of note, its combination readily augmented lysis of CD26neg cell populations, refractory to CD26mAb or HDACi alone. Chromatin immunoprecipitation assay revealed that HDACi increased acetylation of histone 3 lysine 27 at the CD26 promoter of myeloma cells. Moreover, in the absence of HDACi, c-Myc was attached to the CD26 promoter via Sp1 on the proximal G-C box of myeloma cells, whereas, in the presence of HDACi, c-Myc was detached from Sp1 with increased acetylation of c-Myc on the promoter, leading to activation of the CD26 promoter and initiation of transcription in myeloma cells. Collectively, these results confirm that HDACi plays crucial roles not only through its anti-myeloma activity but by sensitizing CD26neg myeloma cells to CD26mAb via c-Myc/Sp1-mediated CD26 induction, thereby augmenting its cytotoxicity.

Significance:

There is a desire to induce and sustain CD26 expression on multiple myeloma cells to elicit superior anti-myeloma response by humanized anti-CD26 mAb therapy. HDACi upregulates the expression levels of CD26 on myeloma cells via the increased acetylation of c-MycK323 on the CD26 promoter, leading to initiation of CD26 transcription, thereby synergistically augments the efficacy of CD26mAb against CD26neg myeloma cells.
Pharmacokinetic Variability of Oral Cannabidiol and Its Major Metabolites after Short-Term High-Dose Exposure in Healthy Subjects
Authors: Zhang Qingchen , Melchert Philip W. , Markowitz John S.
Published: January 2024

Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as a prescriptive drug treatment and over-the-counter supplement. In humans, CBD is metabolized and forms the major active metabolite 7-hydroxy-cannabidiol (7-OH-CBD), which is further metabolized to 7-carboxy-cannabidiol (7-COOH-CBD). In the current study, plasma concentrations of CBD, 7-OH-CBD, and 7-COOH-CBD were measured, and the potential influences of sex, race, and body mass index (BMI) on the pharmacokinetic variability were assessed. Methods: Blood samples from a previously conducted CBD drug interaction study in healthy volunteers (n = 12) were utilized. The subjects received orally administered CBD (Epiodiolex®), 750 mg twice daily for 3 days and a single dose on the 4th day. Nine plasma samples were collected, and plasma concentrations of CBD, 7-OH-CBD, and 7-COOH-CBD were analyzed by LC-MS/MS. Peak plasma concentration (Cmax), time to Cmax (Tmax), area under the curve (AUC), and metabolite‐to‐parent drug exposure ratios (MPR) were calculated. Statistical analysis was performed to determine the correlations of Cmax, AUC, and MPR of CBD, 7-OH-CBD, and 7-COOH-CBD in different sex, race, BMI, and body weight. Results: For CBD, the mean Cmax was 389.17 ± 153.23 ng/mL, and the mean AUC was 1,542.19 ± 488.04 ng/mL*h. For 7-OH-CBD, the mean Cmax was 81.35 ± 36.64 ng/mL, the mean AUC was 364.70 ± 105.59 ng/mL*h, and the mean MPR was 0.25 ± 0.07. For 7-COOH-CBD, the mean Cmax was 1,717.33 ± 769.22 ng/mL, the mean AUC was 9,888.42 ± 3,961.47 ng/mL*h, and the mean MPR was 7.11 ± 3.48. For 7-COOH-CBD, a 2.25-fold higher Cmax was observed in female subjects (p = 0.0155) and a 1.97-fold higher AUC for female subjects (p = 0.0285) with the normalization of body weight. A significant linearity (p = 0.0135) of 7-OH-CBD AUC with body weight in females was observed. No significant differences were identified in Cmax, AUC, and PMR with race and BMI. Conclusion: Observed differences in sex were in agreement with previously reported findings. A larger population pharmacokinetics study is warranted to validate the observed higher Cmax and AUC in females and significant linearity with body weight in females from the current study.
Ciliary Madarosis Secondary to Intra-Arterial Chemotherapy for Retinoblastoma Treatment
Authors: Watts-Santos Anabella , Ancona-Lezama David Arturo , Figueroa-Sanchez Jose A. , Mares-Custodio Daniela , Garza-Rodríguez Verónica
Published: January 2024

Background: Retinoblastoma is the most common intraocular tumor in the pediatric population. Its main therapeutic objectives are to avoid fatal outcomes and preserve vision as much as possible. Intra-arterial chemotherapy (IAC) improves drug delivery and reduces possible systemic adverse effects. This modality allows direct administration of chemotherapeutic agents to intraocular malignancies via the ophthalmic artery (OA), proving to be a feasible and effective method for globe salvage. Most side effects of IAC are local, including eyelash loss of the nasal portion of the eyelid. Summary: We performed a comprehensive review to analyze data regarding ciliary madarosis in patients diagnosed with retinoblastoma treated with IAC. We describe 9 studies with a total of 637 eyes with retinoblastoma that underwent IAC, of which 45 cases presented madarosis. In chemotherapy-induced alopecia, there is hair shaft thinning and breakage. On trichoscopy, the remaining end of the fractured hair will be observed as black dots. Differential diagnoses must include alopecia areata and trichotillomania. Key Messages: Ciliary madarosis secondary to IAC, although transitional, may cause discomfort in patients and family members. Physical examination, as well as a trichoscopic evaluation of the affected area, can help in reaching a prompt diagnosis and prognosis for this particular alopecia.
Late-Onset Capsular Block Syndrome with Pupillary Block Angle Closure after Cataract Surgery with Posterior Chamber Intraocular Lens Implantation: A Case Report
Authors: Yaisiri Panhathai , Funarunart Panrapee , Treesit Isaraporn
Published: January 2024

Introduction: Pseudophakic pupillary block angle-closure glaucoma is an uncommon complication following uneventful cataract surgery with posterior chamber intraocular lens (IOL) implantation. Interestingly, capsular block syndrome (CBS) has been reported as another plausible cause of pseudophakic pupillary block angle-closure glaucoma, especially in the early postoperative period. Unlike early postoperative CBS, late postoperative CBS is not associated with a shallow anterior chamber, myopic shift, or elevated intraocular pressure. We report a case of late postoperative CBS presenting with an acute-onset pupillary block angle-closure attack occurring 13 years after uneventful cataract surgery with posterior chamber IOL implantation, which has not been reported in the literature. Case Presentation: An 87-year-old male diagnosed with pseudoexfoliation syndrome developed pseudophakic pupillary block following uneventful cataract surgery with posterior chamber IOL implantation. Late-onset CBS has been identified as the underlying cause of the pupillary block. The combination of zonular laxity observed in pseudoexfoliation syndrome and the presence of a Soemmering ring are potential predisposing factors for this condition. After performing laser peripheral iridotomy (LPI) followed by Nd: YAG capsulotomy, the pupillary block was resolved and vision was improved. Conclusion: CBS should be considered as a potential cause of pseudophakic pupillary block, even in the late postoperative period. The management of late-onset CBS accompanied by pupillary block angle-closure glaucoma typically includes LPI to eliminate the pupillary block, followed by Nd: YAG capsulotomy.
Rare Case of a Turner Syndrome Patient with Metastatic Dysgerminoma and No Y-Chromosomal Material with Pathogenic Variants Found in KIT and MTOR
Authors: Balle Camilla Mains , Kassentoft Christine Gaasdal , van Heusden Jolinda Iris , Knudsen Michael , Raaby Line , Gravholt Claus Højbjerg
Published: January 2024

Introduction: The presence of Y-chromosomal material in females with Turner syndrome (TS) is a well-established risk factor for developing gonadoblastoma and malignant transformations thereof. However, these events are rarely seen in TS patients with no Y-chromosomal material. Thus, it is the current understanding that parts of the Y-chromosome are essential for the malignant transformation of gonadoblastoma in the dysgenetic gonad. Methods: We report a case of a TS female with an apparent 46,X,idic(Xq) karyotype, who was diagnosed with a metastatic dysgerminoma. Whole exome sequencing of the tumor and blood, along with RNA sequencing of the tumor, was performed to comprehensively search for cryptic Y-chromosomal material and pathogenic variants. Results: No Y-chromosomal material was detected in either tumor or blood. Whole exome-sequencing of DNA and RNA revealed a pathogenic somatic gain-of-function mutation in KIT and a pathogenic missense mutation in MTOR. The patient underwent total hysterectomy with bilateral salpingo-oophorectomy, followed by adjuvant chemotherapy. Unfortunately, she died due to chemotherapy-induced pneumonitis 7 months after the initial diagnosis. Conclusion: Females with TS can develop metastatic dysgerminoma even in the absence of Y-chromosomal material. This questions the current understanding of Y-chromosomal material being essential for the malignant transformation of a gonadoblastoma in the dysgenetic gonad.
Effects of packetization on communication dynamics in brain networks
Authors: Fukushima Makoto , Leibnitz Kenji
Published: January 2024

Computational studies in network neuroscience build models of communication dynamics in the connectome that help us understand the structure-function relationships of the brain. In these models, the dynamics of cortical signal transmission in brain networks are approximated with simple propagation strategies such as random walks and shortest path routing. Furthermore, the signal transmission dynamics in brain networks can be associated with the switching architectures of engineered communication systems (e.g., message switching and packet switching). However, it has been unclear how propagation strategies and switching architectures are related in models of brain network communication. Here, we investigate the effects of the difference between packet switching and message switching (i.e., whether signals are packetized or not) on the transmission completion time of propagation strategies when simulating signal propagation in mammalian brain networks. The results show that packetization in the connectome with hubs increases the time of the random walk strategy and does not change that of the shortest path strategy, but decreases that of more plausible strategies for brain networks that balance between communication speed and information requirements. This finding suggests an advantage of packet-switched communication in the connectome and provides new insights into modeling the communication dynamics in brain networks.
New findings of poronotic oribatid mites (Acari: Oribatida) from Korea
Authors: BAYARTOGTOKH BADAMDORJ , BAE YANG-SEOP
Published: January 2024

This work deals with 13 species of oribatid mites from different regions of Korea. Two new species, Humerobates aokii sp. nov. and Humerobates ulleungdoensis sp. nov. are proposed, and 11 known species, Punctoribates ezoensis (Fujikawa, 1982), Tectoribates proximus (Berlese, 1910), Protoribates tohokuensis Fujikawa, 2003, Protoribates capucinus Berlese, 1908, Peloribates pilosus Hammer, 1952, Scheloribates fimbriatus Thor, 1930, Neoribates aurantiacus (Oudemans, 1914), Zygoribatula glabra (Michael, 1890), Pergalumna myrmophila (Berlese, 1914), Trichogalumna boninensis Hagino, Bayartogtokh & Shimano, 2017, and Trichogalumna ohkuboi Hagino, Bayartogtokh & Shimano, 2017 are newly reported for the fauna of Korea. Supplementary descriptions and illustrations of each species along with their distributional data are provided.
The Orchestra Nocturne: Description For Six New Katydid Species From India (Orthoptera: Tettigoniidae)
Authors: TIWARI CHANDRANSHU , DIWAKAR SWATI
Published: January 2024

The paper describes six new species from three genera of Tettigoniidae. The paper evaluates the status of Hexacentrus Serville 1831, Phyllomimus Stål 1873 and Euconocephalus Karny 1907. Diagnostic characters for new members of each genus are described along with additional information about the ecology and distribution of species. Keys to all species of each genus is presented. Of the six, three namely H. sylavanus sp. nov., E.helleri sp. nov and E. brevicornis are recorded only from Assam. One species, E.latipennis is recorded from Arunachal Pradesh and one species P.midoriyae is recorded from both locations. One species E. malabaricum is recorded from the Alappuzha district, in Kerala. The paper also demonstrates the importance of acoustic signals in taxonomic studies.
Одоризмы как отражение оценочного восприятия в романе Л. Улицкой "Казус Кукоцкого"
Authors: Шимула [Szymula] Роберт [Robert] , Анхимюк [Anchimiuk] Ольга [Olga]
Published: January 2024

Olfactory Vocabulary as a Reﬂection of Evaluative Perception in Ludmila Ulitskaya’s Novel The Kukotsky Enigma
The aim of this article is to analyse the olfactory vocabulary in the novel Kazus Kukotskogo by Ludmila Ulitskaya (2001; English edition: The Kukotsky Enigma, 2016). The issues addressed in the novel are topical and controversial. The theme of the degeneration of Soviet man is revealed against the background of his contacts with the odours of the natural world and the world of civilisation. The study applies a general classification of olfactory vocabulary developed on the basis of the research by M. Schleidt, P. Newman and H. Morishita, as well as N. S. Pavlova.
Explications of smells in the novel include nouns (zapakh, dukh, aromat, dushok), adjectives (pakhuchiĭ, voniuchiĭ, smradnyĭ, smerdiashchiĭ) and verbs (denoting the manifestation of smell: pakhnutʹ, nesti, voniatʹ; denoting the perception of smell: vdykhatʹ, vtianutʹ/vtiagivatʹ, priniukhivatʹsia, chuiatʹ). The evaluative component gradually intensifies as one moves away from nature and approaches the social aspect of human life. The correlation between the concepts of fragrance (good) and stench (evil, sin) is associated with the characteristics of nature and civilisation. The lexemes used to nominate and characterise negatively labelled odours belong to a civilisation that is far from nature and contrary to its values.
Słownictwo dotyczące zapachów jako odzwierciedlenie percepcji wartościującej w powieści Ludmiły Ulickiej Przypadek doktora Kukockiego
Artykuł podejmuje analizę słownictwa dotyczącego zapachów w powieści Казус Кукоцкого Ludmiły Ulickiej (2001; wydanie polskie: Przypadek doktora Kukockiego, 2006). Zagadnienia poruszane w powieści są aktualne i kontrowersyjne. Temat degeneracji człowieka radzieckiego ujawnia się na tle jego kontaktów z zapachami świata natury i świata cywilizacji. W artykule zastosowano ogólną klasyfikację słownictwa dotyczącego zapachów opracowaną na podstawie badań M. Schleidta, P. Newmana i H. Morishity oraz N. S. Pawłowej.
Eksplikacje zapachów w omawianej powieści obejmują rzeczowniki (запах, дух, аромат, душок), przymiotniki (пахучий, вонючий, смрадный, смердящий) i czasowniki (oznaczające przejawianie się zapachu: пахнуть, нести, вонять; oznaczające percepcję zapachu: вдыхать, втянуть/втягивать, принюхиваться, чуять). Komponent wartościujący stopniowo nasila się w miarę oddalania się od natury i zbliżania do społecznego aspektu życia człowieka. Korelacja między pojęciami woni (dobro) i odoru (zło, grzech) jest powiązana z cechami natury i cywilizacji. Leksemy używane do nominacji i charakterystyki negatywnie oznaczanych zapachów należą do cywilizacji oddalonej od natury i sprzecznej z jej wartościami.
Исследования о чешской фразеологии и паремиологии
Authors: Мокиенко [Mokienko] Валерий [Valerii]
Published: January 2024

Research on Czech Phraseology and Paroemiology
Review: Liudmyla Danylenko, Chesʹka frazeolohiia i paremiolohiia: Bibliohrafiia dzherel XIX – 20-kh rokiv XXI st. / Česká frazeologie a paremiologie: Bibliografie pramenů 19. – 20. let 21. století. Vydavnychyĭ dim Dmytra Buraho, Kyїv 2021, 191 pp.
This article is a review of a bibliographic reference book on Czech phraseology and paroemiology compiled by Professor of Kyiv University Liudmyla Danylenko. The rich material included in the volume is organised into five main sections: I. Monographs. Thematic collections; II. Dictionaries; III. Articles; IV. Linguodidactic potential of Czech phraseology and paroemiology; V. Reviews. The book also includes an index, which helps the reader to navigate this rich material effectively. The review offers general information about each section.
Badania nad czeską frazeologią i paremiologią
Recenzja: Людмила Даниленко, Чеська фразеологiя i паремiологя. Бiблiографiя джерел XIX – 20-х рокiв XXI ст. / Česká frazeologie a paremiologie: Bibliografie pramenů 19. – 20. let 21. století. Видавничий дiм Дмитра Бураго, Київ 2021, 191 ss.
Artykuł jest recenzją kompendium bibliograficznego dotyczącego czeskiej frazeologii i paremiologii opracowanego przez profesor Uniwersytetu Kijowskiego Ludmiłę Danylenko. Bogaty materiał zawarty w tomie został ujęty w pięciu częściach: I. Monografie. Publikacje tematyczne; II. Słowniki; III. Artykuły; IV. Potencjał lingwodydaktyczny czeskiej frazeologii i paremiologii; V. Recenzje. Książka zawiera również indeks, który pomaga czytelnikowi w sprawnym poruszaniu się po obszernym materiale. Recenzja przedstawia ogólne informacje o poszczególnych częściach omawianego kompendium.
Звертання до адресата в польськомовному діалозі викладачів та учнів в Україні
Authors: Кравчук [Kravchuk] Алла М. [Alla M.] , Бундза [Bundza] Ірина В. [Iryna V.]
Published: January 2024

Forms of Address in the Polish-Language Dialogue of Teachers and Learners in Ukraine The article presents the results of a questionnaire survey on the forms of address in the Polish-language teaching environment in Ukraine. The analysis is based on 556 statements from 153 questionnaires completed by respondents from 16 towns in different regions of the country. The topic in focus is nominal and pronominal forms of address used by university teachers and teachers at language courses when talking to their students, and those used by learners when addressing their teachers. The study reveals the proportions of use of various forms of address in teaching situations in Ukraine against the background of their normative Polish equivalents. The results indicate, among others, the discrepancy between the teachers’ awareness of the Polish norm and their acceptance or even promotion of the form “pan/pani + name” when addressing the teacher, which is inconsistent with the general Polish language norm. Sposoby zwracania się do adresata w polskojęzycznym dialogu wykładowców i uczących się w Ukrainie Artykuł przedstawia wyniki badań ankietowych nad sposobami zwracania się do adresata w polskojęzycznym środowisku dydaktycznym w Ukrainie. Uwzględniono 556 wypowiedzi pochodzących ze 153 ankiet wypełnionych przez respondentów z 16 miast z różnych regionów Ukrainy. Zbadano nominalne oraz pronominalne sposoby zwracania się wykładowców szkół wyższych oraz kursów językowych do uczących się oraz uczących się do wykładowców. Badania ujawniają proporcje sposobów zwracania się stosowanych w sytuacjach dydaktycznych w Ukrainie na tle normatywnych odpowiedników w polszczyźnie ogólnej. Ujawniono m.in. rozdźwięk między uświadamianiem przez wykładowców normy ogólnopolskiej i akceptowaniem lub wręcz promowaniem przez nich niezgodnej z normą ogólnopolską formy adresatywnej „pan/pani + imię” podczas zwracania się do wykładowcy.
Nominacje Chrystusa w postylli katolickiej Konstantego Szyrwida „Punkty kazań” (1629, 1644)
Authors: Rutkowska Krystyna
Published: January 2024

Nominations of Christ in the Catholic Postil by Konstantinas Sirvydas (Konstanty Szyrwid) Points of Sermons (1629, 1644) The article presents an analysis of the structure and semantics of the nominations referring to Christ recorded in the Catholic postil by Konstantinas Sirvydas (Konstanty Szyrwid). The study aims to show how they are created and what function they play in the text of the sermonic work. By examining the name as an individual product of the author, we position our research at the crossroads of theology and linguistics, and use the methodology of cultural onomastics. The structural analysis of the names shows that there are single and multi-component nominations in the text, as well as names extended with predicative and textual descriptions. Most of them are of biblical origin, but there is also paraphrasing present of biblical descriptions, their reduction or transformation, which results in the creation of new names based on postillic text. The semantic analysis of the names allows us to reach the content of the sermons, reflects on the thoughts and arguments they contain, and reveals the attitude of the author. The results of the study indicate that the basic source of biblical anthroponymy in the Polish language in the sixteenth and seventeenth centuries was not only the Holy Bible, but also parabiblical works. Nominacje Chrystusa w postylli katolickiej Konstantego Szyrwida Punkty kazań (1629, 1644) W artykule została przedstawiona analiza struktury i semantyki nominacji określających Chrystusa, utrwalonych w postylli katolickiej Konstantego Szyrwida. Celem opracowania jest ukazanie sposobu ich tworzenia oraz funkcji, jaką pełnią w tekście utworu kaznodziejskiego. W niniejszym studium nazwa jest rozpatrywana jako wytwór indywidualny autora, a omówione tu badania sytuują się na pograniczu teologii i językoznawstwa. W opracowaniu wykorzystana została też metodologia onomastyki kulturowej. Z analizy strukturalnej nazw wynika, że w tekście występują nominacje jedno- i wieloskładnikowe oraz nazwy rozbudowane o deskrypcje predykatywne i tekstowe. Większość z nich ma proweniencję biblijną, ale zdarza się również parafrazowanie deskrypcji biblijnych, ich redukcja lub przekształcenie, a także tworzenie nowych nazw na podstawie tekstu postyllicznego. Analiza semantyczna nazw pozwala dotrzeć do treści kazań, stanowi odbicie zawartych w nich myśli i sposobów argumentacji oraz ujawnia postawę autora postylli. Z badania wynika, że za podstawowe źródło antroponimii biblijnej w języku polskim w XVI–XVII wieku należy uznać nie tylko Pismo Święte, ale też utwory parabiblijne.
Funkcje par wyrazów ze zbiorów opozycji semantycznych wieloczłonowych w zdaniach z tekstów Narodowego Korpusu Języka Polskiego
Authors: Mikołajczak-Matyja Nawoja
Published: January 2024

Functions of Pairs of Words from Sets of Non-Binary Semantic Oppositions in Sentences from the Texts of the National Corpus of Polish
The article attempts to investigate whether pairs of words from sets of non-binary semantic oppositions perform the same functions in sentences as strong semantic binary oppositions. Six noun pairs were selected for analysis: summer/winter, arm/leg, cat/dog, coffee/tea, trousers/skirt and telephone/letter. A total of 1,200 sentences in which members of one of these six pairs co-occur were analysed; they were selected from the balanced sub-corpus of the National Corpus of Polish. A set of nine basic functions is presented, which has been applied in works on various languages in recent decades. The functions are identified by determining the mutual relationship between the members of the pair, based on the semantic-syntactic analysis of the immediate context and the meaning of the whole sentence. The present study confirms the usefulness of almost all the functions from the set for describing the way the analysed pairs are used in the sentences from the corpus. Apart from this, it was found that the same two functions are the strongest in the present study as in this type of analysis concerning strong binary oppositions.
Funkcje par wyrazów ze zbiorów opozycji semantycznych wieloczłonowych w zdaniach z tekstów Narodowego Korpusu Języka Polskiego
W artykule podjęto próbę sprawdzenia, czy pary wyrazów ze zbiorów opozycji semantycznych wieloczłonowych pełnią w zdaniach takie same funkcje, jak pary stanowiące silne opozycje semantyczne dwuczłonowe. Do analizy wybrano sześć par rzeczownikowych: lato/zima, ręka/noga, kot/pies, kawa/herbata, spodnie/spódnica i telefon/list. Ze zrównoważonego podkorpusu Narodowego Korpusu Języka Polskiego wyselekcjonowano 1200 zdań, w których współwystępują człony jednej z tych sześciu par. Przedstawiono zestaw dziewięciu podstawowych funkcji, wykorzystywany w ostatnich dziesięcioleciach w pracach dotyczących różnych języków. Funkcje wyodrębniane są poprzez określenie wzajemnej relacji między członami pary na podstawie analizy semantyczno-składniowej kontekstu bezpośredniego i ustalenia znaczenia całego zdania. Niniejsze badanie potwierdziło użyteczność prawie wszystkich funkcji z zestawu do opisu sposobu użycia badanych par w zdaniach z korpusu. Ponadto stwierdzono, że w obecnym badaniu najsilniejsze są te same dwie funkcje co w analizach tego typu dotyczących silnych opozycji binarnych.
Ku pamięci. W 95. rocznicę urodzin prof. dra hab. Adama Supruna
Authors: Kozhinowa Alla , Rudenka Alena
Published: January 2024

In Memoriam: On the 95th Anniversary of the Birth of Professor Adam Suprun
The article is dedicated to the memory of Professor Adam Suprun on the 95th anniversary of his birth. It provides a brief overview of his biography, scholarly activities and research interests, and presents his main works and his school of thought.
Ku pamięci. W 95. rocznicę urodzin prof. dra hab. Adama Supruna
W artykule z okazji 95. rocznicy urodzin prof. Adama Supruna omówiono jego biografię, pracę zawodową i zainteresowania naukowe. Przedstawiono jego osiągnięcia i najważniejsze dzieła oraz szkołę naukową prof. Supruna.