bluuebunny/crossref_metadata_2025 huggingface dataset:
THE PROBLEM OF THE OSCILLATION OF THE ELASTIC LAYER BOUNDED BY RIGID BOUHDARIES
Authors: Seitmuratov Angisin  , Tileubay Sarsenkul  , Toxanova Sveta  , Ibragimova Nuraim  , Doszhanov Bayanalui  , Aitimov Myrat
Published: October 2018

In the case of harmonic oscillations of a cylindrical shell, the phase velocity is expressed in terms of the frequency of natural oscillations freely supported along the edges of the shell, and therefore, the study of waves in plane and circular elements has the most direct relation to the problem of determining its own forms and oscillation frequencies shells finite length. Below let us consider some problems of oscillation of an elastic layer bounded by rigid boundaries under the influence of a normal or rotational shear stress. The solutions of the problems under consideration are obtained by using integral transformations by the coordinate.
Key words: harmonic oscillations, cylindrical shells, phase velocity, frequency, eigenvibrations, Bessel function, wave, anisotropic, layer.
Rheological parameters of saliva in comparison with taste examination
Authors: Marcinkowska-Gapińska Anna , Linkowska-Świdzińska Kamila , Świdziński Teodor , Surdacka Anna
Published: October 2018

BACKGROUND:

It is generally unknown if taste sensitivity is dependent upon saliva viscosity. The rheological properties of saliva result from many factors and it has been shown to behave as a non-Newtonian fluid whose viscosity decreases with increasing shear rate. Taste sensitivity may be quantitatively assayed by electro-gustometry.

OBJECTIVES:

The aim of this work was to compare saliva rheological properties, obtained with a rotary-oscillating rheometer, to quantitative measures of taste sensitivity, using electro-gustometry.

METHODS:

Saliva samples were taken from 27 healthy non-smoking donors – 7 men and 20 women aged 18–65 years (mean age – 37 years). After thresholds of taste sensation were measured, the saliva samples were taken and characterized in terms of their rheological properties and pH. Saliva viscosity was measured in the order of decreasing shear rate in the range 100–0.01 s−1. Viscoelastic properties were examined under constant frequency oscillations (with f = 0.5 Hz) and with decreasing shear effective amplitude [Formula: see text].

RESULTS and CONCLUSIONS:

Saliva viscosity was found to decrease with increasing shear rate and varied with time. Analysis of the dependence of the viscosity values of saliva and components of complex viscosity did not show a significant correlation with taste sensation. A dependency of taste sensation on pH could not be discerned due to the narrow range of naturally occurring pH.
Thermo Reversible Hydrogel Based Delivery of Mitomycin C (UGN-101) for Treatment of Upper Tract Urothelial Carcinoma (UTUC)
Authors: Kleinmann Nir , Wirth Gregory , Lin Jeffrey S. , Matin Surena F. , Nativ Ofer , Mayer Gil , Witjes J. Alfred , Shvero Asaf , Chamie Karim , Pantuck Allan J. , Smith Angela , Schoenberg Mark , Malchi Nadav , Hakim Gil , Agmon-Gerstein Yael , Jeshurun-Gutshtat Michal , Klein Ifat , Kopelen Helen , Lerner Seth P.
Published: October 2018

Background:

There is an unmet need for an effective local treatment of upper tract urothelial carcinoma (UTUC). Drug delivery to the pyelocaliceal system and pursuant efficacy of intracavitary therapy is limited by urine production that washes the drug away, shortening dwell time and direct contact with the urothelium. Successful endoscopic management is often dictated by lesion size, grade, and focality. A thermo-reversible hydrogel formulation of Mitomycin C (UGN-101, formerly MitoGel) was developed and has demonstrated the safety and feasibility of increased time of the drug in the pyelocaliceal system resulting in chemoablation of tumors.

Objectives:

To examine the efficacy and safety of UGN-101 used for chemoablation of UTUC.

Methods:

There were 22 patients approved for compassionate use treatment at 14 institutions. Six-weekly instillations of UGN-101 were administered via ureteral catheter or percutaneous nephrostomy. Ureteroscopy was performed 2–6 weeks following treatment completion for response determination. Adverse events were recorded throughout treatment. Patients were followed up according to the standard of care of each center.

Results:

Median age of the cohort was 75 yrs., with 16 (73%) males. Eighteen patients had low-grade (LG) tumors, 2 high-grade (HG), and 2 had indeterminate grade. Median volume of UGN-101 instilled was 13.5cc with median Mitomycin dosage of 54 mg. Eight patients had complete response (36%) including 44% (8/18) of the patients with low grade tumors. Partial responses were observed in 23% and 28% of LG. Two patients had no response (9%) and 1 did not undergo ureteroscopy. Four patients could not complete 6 weeks due to adverse events (pyelonephritis, acute renal failure, pancytopenia, and unstable cardiac condition); 1 patient was diagnosed with a non-urothelial cancer during treatment; and 1 patient died prior to the third instillation due to suspected pulmonary embolus, determined to be unrelated to treatment with UGN-101. Out of the patients who had a complete response, 3 (37.5%) patients are recurrence free from 18–30 months. A total of 83 adverse events were recorded. Of these, 6 events related to UGN-101 were serious (requiring medical intervention), and 23 events related to UGN-101 were not serious.

Conclusions:

This compassionate use program of UGN-101 demonstrates proof of concept for chemoablation treatment of UTUC. A single arm Phase III multi-center registration trial to treat patients with low-grade low-volume renal pelvis tumors is open and enrolling patients (NCT02793128).
The ICF story: The evolution of a multi-stranded global society
Authors: Taplin D.M.R.
Published: October 2018

This paper addresses the history of ICF 1969–2017 and the challenges ahead for a new era of ICF 2017–2029. In 1969 ICF was established in Brighton, UK with a governing constitution via the Statutes & Bye-Laws. These Statutes & Bye-Laws are indeed an evolving, living document with progressive revisions followed over the decades since 1969. Many evolutions in developing our now mature ICF culture and modus operandi have occurred over the years. There will be others in the challenging era ahead 2017–2029 via ICF14, ICF15, ICF16 & ICF17 but we might highlight: (1) The Gold & Silver Medals introduced in 2009 at ICF12 as an important extra-statutory evolution of ICF for the benefit of our global brand via AwardCo; (2) The Honour Lectures introduced in 1977 at ICF4 via Ashby/Bilby and followed to the highest standard therefrom; (3) The MoU System to assure the autonomy and independent organization of our quadrennials in the context of the ICF Culture introduced at ICF12 via the Canadian Government and developed for ICF13, ICF14 & ICF15; (4) The Quadrennials Regional Rotation guideline introduced at ICF6 in 1984 to ensure wide global participation; (5) The Interquadrennials Programme initiated in 1983 in Beijing after ICF5 and continued very actively since ICF12 with various ICF regions; (6) The Enlarged Portfolio-Based ExCo introduced at ICF13 for wider representation and “New Blood”; (7) The Enhanced Accreditation of voting Council members to be introduced at ICF14 via NomCo; (8) The Multi-Stranding of the original ICF micro/macro brand from ICF4 and progressively at each quadrennial including geo-physics, biomedical, bio-engineering, non-metallics, computational mechanics, adhesion, nano-scales, sustainabilty, energy, education, politics/society, safer engineering, risk & disaster analysis; (9) The ICF Website and accessibility to all our Proceedings introduced via IGF after ICF12; (10) The Regional Groups in the Far-East, Iberia/Latin America, Africa, India, Australasia, Europe, Canada, Egypt and variously from 1976 onwards originally via Dominique in Compiegne, France and EGF; (11) The Chief Executive-Treasurer role in structured leadership since ICF6; (12) The ICF Culture of friendly, human, transparent, democratic, harmony-oriented – respecting past contributions of “heavy-lifters” via emeritus standing and FICF election – towards Safer, Sustainable Technology for the common good.
Formação para profissionais de unidades de telessaúde – para além da capacitação profissional
Authors: Baptista Silva Angélica , Guedes Ana Cristina Carneiro Menezes , Castro Gláucia Regina Motta da Silveira , Cavalcanti Maria de Lourdes Tavares , Gomide Márcia
Published: October 2018

A telessaúde é fundamental para ampliar e qualificar a atenção à saúde. Estima-se haver mais de dois mil pontos de telessaúde no Brasil, cobrindo a Atenção Básica, em especial, o Programa de Saúde da Família, prestando suporte clínico e pedagógico a médicos e equipes em diversos rincões. Nesse contexto, necessita-se de estratégias de formação e educação permanente de profissionais habilitados a manejar tecnologias de telessaúde, que, além do conhecimento técnico relativo aos equipamentos, atuem na perspectiva da universalização, equidade e integralidade da atenção à saude. Assim, apresenta-se a estruturação e consolidação de um modelo de formação em telessaúde, contemplando o eixo técnico-político-administrativo do sistema de saúde com vistas a estender o campo de ação e reflexão sobre os modos de pensar/fazer telessaúde. Prioriza-se a dimensão de internalização do profissional no modelo de colaboração interprofissional, contemporizando saber técnico e conduta ética.
MENINGKATKAN KEMAMPUAN MEMBACA AWAL AL-QUR�AN MELALUI METODE ALBANA PADA ANAK USIA 5-6 TAHUN
Authors: Setiawan Eko
Published: October 2018

As an institution that is concerned with Islamic Education, especially the Qur'an, TK Aisyiyah 19 Bandung has made Al-Qur'an education as a priority curriculum. Based on this, the author tries to apply the Al-Qur'an learning method that is more interesting, by using Al-Bana Al-Quran learning method (story-based).The purpose of this study was to improve the early reading abilities of Al-Qur'an children in group B TK Aisyiyah 19 Bandung.The method used in this research is descriptive qualitative method, with the type of classroom action research.The results of this study indicate that the application of Al-Bana Al-Quran learning method influences the early reading ability of Al-Quran children aged 5-6 years in TK Aisyiyah 19 Bandung.
Penerapan Analisis SWOT dan Five Forces Porter Sebagai Landasan untuk Merumuskan Strategi Pemasaran dalam Meningkatkan Laba Perusahaan (Studi Pada Tin Panda Collection di Kabupaten Magelang)
Authors: Meftahudin Meftahudin , Putranto Agus , Wijayanti Ratna
Published: October 2018

Penelitian ini bertujuan untuk mengetahui bagaimana penerapan analisis SWOT dan Porter’s Five Forces Model sebagai landasan untuk merumuskan strategi pemasaran dalam meningkatkan laba perusahaan. Penelitian ini dilakukan pada CV Tin Panda Collection di Kabupaten Magelang Jawa Tengah. Metode analisis yang digunakan adalah dengan metode analisis data kuantitatif dan studi kasus. Penelitian ini menghasilkan bahwa di dalam lingkungan Tin Panda Collection terdapat kekuatan dan kelemahan perusahaan. Kekuatan dari perusahaan antara lain adalah; produk berkualitas tinggi, perusahaan yang memiliki reputasi dan kredibilitas tinggi. Terdapat pula kelemahan dari perusahaan yaitu Tin Panda Collection belum memiliki ijin usaha. Lingkungan eksternal dari Tin Panda Collection yaitu lingkungan industri dan lingkungan jauh. Lingkungan industri meliputi; ancaman pendatang baru, daya tawar pemasok, daya tawar konsumen. Selain itu lingkungan luar perusahaan meliputi; politik, ekonomi, sosial, dan teknologi. Faktor yang paling berdampak terhadap Tin Panda Collection adalah faktor persaingan dengan perusahaan sejenis. Strategi yang digunakan perusahaan saat ini merupakan strategi intensif dengan strategi pengembangan pasar (market development). Strategi ini dilakukan dengan memperkenalkan produk yang sudah ada ke wilayah geografis baru. Sedangkan hasil penelitian lima kekuatan Porter pada Tin Panda Collection bahwa faktor persaingan di dalam industri tinggi, kekuatan tawar-menawar pemasok tinggi, kekuatan tawarmenawar pembeli tinggi. Faktor persaingan di dalam industri tinggi karena pertumbuhan industri yang meningkat, jumlah pesaing yang ada semakin banyak, perusahaan memiliki biaya yang berbeda, dan hambatan keluar tinggi yang menyebabkan kondisi persiangan yang terjadi. Faktor kekuatan tawar-menawar pemasok tinggi karena konsentrasi pemasok tinggi, kemampuan pemasok melakukan integrasi ke arah depan tinggi, dan ketergantungan pemasok dengan industri tinggi. Faktor kekuatan tawar menawar pembeli tinggi karena pembeli memiliki switching cost tinggi terhadap Tin Panda Collection yang mengutamakan kualitas dan informasi yang didapat pembeli tidak dapat membuat pembeli dapat mengontrol harga yang ditawarkan Tin Panda Collection. Faktor ancaman pendatang baru tinggi karena modal yang dibutuhkan tidak besar dan menguntungkan. Hasil evaluasi peluang dan ancaman menggunakan matriks, Tin Panda Collection menunjukkan bahwa respon perusahaan terhadap lingkungan industri berada di atas rata-rata. Artinya Tin Panda Collection bisa memaksimalkan peluang dan mengatasi ancaman dari faktor eksternal.

 

Kata Kunci: Analisis SWOT, Porter’s Five Forces Model, Strategi pemasaran
Narrator’s discourses in stories by Doan Minh Phuong
Authors: Thai Tham Thi Thu
Published: October 2018

Narrator’s discourses in stories by Doan Minh Phuong perform the functions of narration, description and comment. Such expressive discourses not only participate in creating emotion for the stories but also carry symbolic meanings. In addition, narrator’s discourses in stories by Doan Minh Phuong express the combination of different literary genres and art types.
Positive impacts of foreign direct investment on socioeconomic development in Vietnam’s Southern Key Economic Region
Authors: Pham Hung Van
Published: October 2018

This paper evaluates the attraction of foreign direct investment (FDI) and its positive impacts on the socioeconomic growth in the special economic zones in Vietnam’s Southern Key Economic Region. Findings of the study confirm theories of FDI attraction. In particular, to promote the socioeconomic development in each area, it is necessary to improve the investment environment and enhance the FDI. Furthermore, the findings also provide researchers and policy makers a more comprehensive understanding about the current situation of the FDI attraction in the special economic zones in the Vietnam’s Southern Key Economic Region
Development of raw material to serve Vietnam’s wood industry towards a sustainable development
Authors: Tran Hung Van
Published: October 2018

The Vietnam’s wood industry has obtained many encouraging achievements in recent years. In order to develop sustainably, the wood industry needs to ensure the quality of human resource, technology, capital, market and especially the material. As material accounts for a large share of the production cost, it is necessary to ensure both quantity and quality of its in the near future as well as in the longterm. The fact that most of raw material is imported seriously affects the Vietnam’s wood industry, such as reducing the activeness and competiveness of Vietnamese wood companies. This paper aims to evaluate the practice of raw material for Vietnam’s wood industry, thereby suggesting some solutions to sustainably develop the raw material for the wood industry.
Orientation of the development of vietnam financial reporting standards for small and medium - sized entities compatible with the international financial reporting standards for small and medium sized entities
Authors: Nguyen Hung Xuan , Ho Thuy Xuan
Published: October 2018

Differences in financial reporting systems for small and medium sized entities(SMEs)and large ones have caused plenty of controversies in the last few decades, especially after the introduction of the International Financial Reporting Standards for Small and Medium sized Entities (IFRS for SMEs) by International Accounting Standards Board (IASB). Bohusova & Blaskova [3]suggested that there existed a preference in many developing countries where the quality of financial reporting was normally considered sub-average for applying the IFRS for SMEs due to strong demand in international economic integration and higher quality financial reporting standards, to which Vietnam is also no exception. Therefore, further research of the IFRS for SMEs in Vietnam is highly desired. This paper shall present a review of concepts of SMEs and the IFRS for SMEs, followed by a comparison of some notable differences between the IFRS for SMEs and the current Vietnamese Accounting Standards (VAS) for SMEs. A summary of many worldwide, mainstream thoughts of the development of financial reporting standards for SMEs is also included. On that basis, prospective proposals for the development orientation of financial reporting standards for SMEs in Vietnam are suggested in order to help Vietnamese SMEs to meet the universal trend of convergence of international accounting.
Preclinical research of the experimental preparation “Ferosel T”
Authors: Todoriuk V.B. , Hunchak V.M. , Gutyj B.V. , Gufriy D.F. , Hariv I.I. , Khomyk R.I. , Vasiv R.O.
Published: October 2018

The results of preclinical studies of the new ferrodextran preparation “Ferosel T”, which contains ferrum and selenium, are presented. It has been established that at oral administration of ferrocellus T in a prophylactic dose of 2 ml/kg b.w. and the therapeutic dose of 4 ml/kg for 3 days in a row in the stomach of laboratory rats did not show toxic effects. No toxic effect of T ferrocellus is established at introducing it into the stomach in doses in 3 and 10 times higher than the therapeutic ones. Under conditions of subcutaneous administration of the drug, the death of white rats was not observed, only short-term inhibition of laboratory animals, which was prescribed the drug in a dose of 10 ml/kg b.w. It was established that in the preventive and optimal therapeutic doses the drug did not affect the detoxification function of the liver. In rats, which ferrocellus T was administered at maximum therapeutic and possibly toxic doses, the duration of hexenal sleep was for 32 and 35% higher relative to control values. The investigation of the emotional and behavioral reactions of laboratory animals after administration of ferrocellus T for 21 days in therapeutic and maximum therapeutic doses did not show a significant effect on the nervous system. In terms of hyperemia and swelling of the skin and the thickness of the skin, ferrocellus T in prophylactic and therapeutic doses upon application to rabbit skin did not cause local irritation. Separate injection of the drug “Ferosel T” by sub-planar way to guinea pigs in 0.1 ml. did not cause swollen reactions of the paws. As a result of the conducted research, no allergenic properties of the drug “Ferosel T” were found. In laboratory rats, which were introduced ferrosel T in the prophylactic dose of probable changes in the weight of the heart, liver, spleen and kidneys is not established. In rats, which were administered ferrocellus T in an optimal therapeutic dose, in comparison with control weights of the spleen and liver, respectively, was in 10.3 and 6.4% higher. When introducing ferrocellus T at the maximum therapeutic dose, the mass of the spleen and liver was in 14.0 and 15.0% higher, respectively. The results of the studies indicate that the drug “Ferosel T” is safe when used for the prevention and treatment of animals.
Assistance Influence on Labor Pain Level
Authors: Seno Adjie JM , Putri Ruth WR
Published: October 2018

Objective: To assess assistance influence on labor pain level.

Method: This study was a randomized-clinical, unmasked trial with

concealment by measuring labor pain level in two patients group:

with and without assistance during labor; each group consisted of 36

subjects. Pain intensity were measured using Faces Pain Rating

Scale. Mann-Whitney analysis was done to assess significance of

pain level between two groups.

Result: Majority of patient who were in non-assisted group had very

painful score 50% with mean of VAS 7.38±2.12, meanwhile most of

assisted group complained painful score 44.44%, with mean of VAS

6.11±1.90.

Conclusion: There was significance level of painful score between

non-assisted and assisted subjects x(p
Fetal Fibronectin (fFN) on the Imminent Premature Parturition in Correlation with Incidence of Preterm Labor
Authors: Keman Kusnarman , Nugrahanti Prasetyorini , Supriany Ni Wayan
Published: October 2018

Objective: To determine the relationship of fFn levels in cervicovaginal

discharge of pregnant women who experience imminent

premature parturition with the incidence of preterm labor.

Method: The study was carried out with Analytic Observational Prospective

Cohort using cervicovaginal discharge of pregnant women

that experienced imminent premature parturition taken from the

delivery room of Obstetrics and Gynecology department dr. Saiful

Anwar Hospital, Malang as well as Bangil Hospital and Ngudi

Waluyo Wlingi Hospital. Statistical analysis was performed using the

Shapiro-Wilk test and comparison test used independent samples t

test for normal data, Mann-Whitney test if not. All analysis used SPSS

for Windows 19.0 software.

Result: Thirty two patient samples was examined, 14 patients

(43.75%) were primigravida and 18 patients (52.56%) is multigravida.

17 of these patients (53.13%) experienced aterm labor and

15 patients (46.87%) experienced preterm labor. Mann-Whitney

test of the mean fFN levels between the aterm group (13.01 ± 7.57

ng/ml) and the preterm group (56.29 ± 27.77 ng/ml) showed a significant

difference (p-value = 0.000 > 0.05). Moreover, Spearman’s

Rho correlation test also showed a strong correlation between fFN

level and incidence of preterm labor (R = 0.797, p < 0.05).

Conclusion: fFN levels is significantly increase in cervicovaginal discharge

from pregnant women with imminent premature parturition

who experience preterm labor than pregnant women who experience

aterm labor. Therefore, this result suggests that fFN has potential

ability to become useful modality in preterm labor diagnosis.

[Indones J Obstet Gynecol 2016; 1: 8-14]

Keywords: cervicovaginal discharge, fFN, imminent premature parturition,

preterm labor
Curcumin Administration on Proliferation and Apoptosis Index in Complete Hydatidiform Mole CellCulture
Authors: Nurseta Tatit , Irwanto Yahya , Imelda Imelda
Published: October 2018

Objective: To investigate that curcumin can decreasing proliferation

index and increasing apoptosis index.

Method: This is an experimental non-blinded study with post test

control group design, at Cell/Tissue Culture Laboratory at Medical

Faculty of Brawijaya University. This study using CHM trophoblastic

cell culture from CHM curettage patient, exposed by several doses of

curcumin, 0, 50, 100, 200, 400 and 800 μM, then examined by the

method of MTT proliferation index and apoptosis index by the

method of labeling DNA fragmentation TUNEL system. Data analyzed

by one-way ANOVA.

Result: In this study, the mean values obtained decrease in proliferation

index with increasing doses of curcumin. Giving a dose of

200 μM curcumin, 400 μM and 800 μM proved highly significant

(p = 0.001) reduced proliferation index compared with the control

and curcumin dose of 50 μM and 100 μM. From this research shows

that there are significant differences in the increase of apoptosis index

(p = 0.001) between the control group with curcumin dose

group 200 μM, 400 μM and 800 μM. But there was no significant

difference in the mean of apoptosis index among the three dose

groups.

Conclusion: Giving curcumin dose of 200 μM can decreasing the

proliferation index and increasing the apoptosis index increases in

CHM trophoblastic cell culture.

[Indones J Obstet Gynecol 2016; 1: 37-41]

Keywords: apoptosis index, curcumin, proliferation index
Theurapeutic Response of Neoadjuvant Chemotherapy between Platinum and Ifosfamide Combination and Platinum, Vincristine and Bleomycin Combination in Cervical Carcinoma Stage IB2
Authors: Nuryanto Kartiwa H , Purbadi Sigit
Published: October 2018

Objective: To evaluate the theurapeutic response and acute toxicity

of neoadjuvant chemotherapy between the combination of Platinum

and Ifosfamide, and the combination of Platinum, Vincristine and

Bleomycin in Cervical Carcinoma Stage IB2 and then continued with

radical hysterectomy and pelvic lymphadenectomy.

Method: Thirteen samples received neoadjuvant chemotherapy of

Platinum and Ifosfamide and 17 samples received neoadjuvant chemotherapy

of Platinum, Vincristine and Bleomycin, after receiving

the neoadjuvant chemotherapy, clinically complete response samples

underwent radical hysterectomy and pelvic lymphadenectomy

(PI VS PVB = 3 VS 1). Histopathology examination was performed to

evaluate the presence of malignant viable cells at the cervix, pelvic

lymph node metastasis and parametrium metastasis. Acute toxicity

evaluation was performed based on gastrointestinal, genitourinarius

and hematology sign and symptom.

Result: Theurapeutic response of PI is 1.12 higher than PVB

(p>0.05). Subanalysis of group response of PI is 1.962 higher than

PVB. PI and PVB have the same risk to have pelvic lymph node metastasis,

but not parametrial metastasis. There were no differences

in terms of the risk of gastrointestinal, genitourinarius and hematologic

toxicity between PI and PVB.

Conclusion: There was no statistical difference in clinical and

pathological response, and also in acute toxicity between the two

combination (p>0.05).

[Indones J Obstet Gynecol 2016; 1: 47-51]

Keywords: acute toxicity, cervical carcinoma stage IB2, neoadjuvant

chemotherapy, response
Female Sexual Function after Vaginal Delivery with Episiotomy and Cesarean Section
Authors: Jembawan I Made W
Published: October 2018

Objective: To determine the difference of sexual function after vaginal

delivery with episiotomy and cesarean section in Sanglah Hospital,

Denpasar.

Method: This research was conducted using cross sectional method.

Sample was collected using consecutive sampling, starting from October 2011-September 2012. Our sample consists of 86 women, 43 post-episiotomy and 43 post-cesarean section. Sexual function was assessed using FSFI (Female Sexual Function Index). Total score was analyzed using independent t-test and difference of sexual function was tested using Chi-square, with significance level p0.05). There was no significant difference between the two groups in term of sexual arousal and lubrication, with p-value 0.160 and 0.67, respectively. However, we found significant difference in other domains, namely desire (p=0.014), orgasm (p=0.045), satisfaction (p=0.018), pain (p=0.02), and total FSFI score (p=0.006). Sexual dysfunction was found in 18.60% of the episiotomy group and 2.33% of the cesarean section group, with p=0.030.

Conclusion: Female sexual dysfunction was found to be significantly

different between women post vaginal delivery with episiotomy and

women who had cesarean section.

[Indones J Obstet Gynecol 2014; 4: 199-203]

Keywords: cesarean section, episiotomy, female sexual function
Maternal Age, Abortion and Aneuploidy
Authors: Hestiantoro Andon
Published: October 2018

N/A
Prevalence of Postpartum Anxiety and Depression after Intrapartum Oxytocin
Authors: Valentine Grace , Kayika I Putu G
Published: October 2018

Objective: To know the prevalence of postpartum anxiety and depression

in patients who received intrapartum oxytocin.

Method: Across-sectional observational study was conducted in Dr.

Cipto Mangunkusumo hospital. Observation used Edinburgh Postnatal

Depression scale and Beck Anxiety Inventory before delivery

day, on the first and fourteenth day of postpartum.

Result: Of 112 patients, we found the prevalence of mild and moderate

anxiety were 94.6% and 5.4%. There were no anxiety women

before delivery and on the first day of postpartum. The prevalence

of mild and moderate anxiety on the fourteenth day of postpartum

were 83% and 16.9%. There was no severe anxiety found at those

time. On the other hand, the prevalence of postpartum depression

on the first and fourteenth day of postpartum were 31.3% and

32.1%. There was no association between exogenous oxytocin and

postpartum anxiety also depression. In multivariate analysis, we

found that women with low self image were more prone to postpartum

anxiety (OR 0.16, 95% CI 0.06-0.46). Meanwhile, postpartum

depression was associated significantly to self image (OR 0.17, 95%

CI 0.07-0.83), low income (OR 10.35, 95% CI 1.72-62.45) and pregnancy

plan (OR 0.17, 95% CI 0.06-0.53)

Conclusion: The patients who received intrapartum oxytocin are

more prevalent to have mild anxiety. The prevalence of depression

before delivery day, on the first and fourteenth day of postpartum

are similar. In statistic, there is no relationship between intrapartum

oxytocin administration and postpartum anxiety or depression.

[Indones J Obstet Gynecol 2016; 4-2: 59-63]

Keywords: anxiety, depression, oxytocin intrapartum, postpartum
The Outcomes of Primary Debulking Surgery and Neoadjuvant Chemotherapy in Advanced Ovarian Cancer
Authors: Rinaldy Dino , Andrijono Andrijono , Sutrisna Bambang
Published: October 2018

Objective: To compare the outcomes and survival rate of primary

debulking surgery with neoadjuvant chemotherapy.

Method: We selected advanced ovarian cancer patients from medical

records. Subjects were allocated into groups of primary debulking

surgery and neoajuvant chemotherapy by considering the inclusion

and exclusion criteria. We analyzed the data using T test,

Fisher’s exact, and chi-square. The survival rate was presented in

Kaplan Meier curve, whereas the significance was tested with Logrank.

We managed the data using STRATA software version 12.

Result: We obtained 32 cases of primary debulking surgery group

and 20 cases of the neoadjuvant chemotherapy group. Most of the

subjects (44.2%) were 40-49 years old and 80.8% had delivered

more than twice. The mean value of Ca-125 at admission was

3,594.8 u/ml (range 66.6 to 73,000 u/ml). Total of 31 subjects

showed the serous histologic type (59.6%). There was no association

between primary debulking surgery and neoadjuvant chemotherapy

for the parameter of operative time, blood loss, organs injury,

ICU stay, and hospital stay (p>0.05). Primary debulking surgery

had a survival rate similar to neoadjuvant chemotherapy group

(p=0.95).

Conclusion: The perioperative outcomes of advanced ovarian cancer

patients has similar result between primary debulking surgery

and neoadjuvant chemotherapy. Primary debulking surgery has a

survival rate similar to neoadjuvant chemotherapy group.

[Indones J Obstet Gynecol 2016; 4-2: 111-115]

Keywords: advanced ovarian cancer, neoadjuvant chemotherapy,

primary debulking surgery
Vitamin D Supplementation to Reduce the Risk of Preeclampsia: Is It True?
Authors: Sungkar Ali
Published: October 2018

N/A
Maternal and Fetal Outcome on Pregnancy in Advanced Maternal Age
Authors: Dewi Sianty , Ferry Ferry , Toynbee Eddy , Prayudhana Sandhy
Published: October 2018

Objective: Pregnancy in advanced maternal age (AMA) was classified as high risk. The study aims to provide a better description of pregnancy outcome in AMA.

Method: The cross sectional study was to review the demography, medical and obstetrics problems, mode of delivery, maternal and fetal outcome in Tangerang General Hospital as a referral center in Banten. The data were taken from medical records of 35-year-old and above women age who delivered on the period of January to December 2014.

Result: The total number of delivery and live birth was 6,107 and 5,926 respectively, including 1,548 (25.36%) pregnancies in AMA. The prevalence of grandmultiparities was 11.4%. The average education level was mostly elementary. The prevalence of hypertension in pregnancy was 34.6%. There was increasing trend of miscarriages from 10.8% in 35-40-year-old group to 25% in above 45- year-old group. Pregnancy complications were higher consisting of 3.2% multifetal, 16.6% malpresentation, and 7.1% placenta previa. Cesarean section rate was 33.6%. Maternal near-missed cases were 56 of 1000 and the maternal mortality rate (MMR) was 932 of 100,000 live births. The prevalence of stillbirth and perinatal mortality were 5.3% and 12.9%; respectively.

Conclusion: Adverse maternal and fetal outcome were higher in AMA as it takes special attention and multidiscipline-approached care started from preconception, antenatal, preparation of delivery, and also postpartum care.

Keywords: advanced maternal age (AMA), fetal outcome, maternal outcome, pregnancy
Family Planning Problem in Indonesia
Authors: Gunardi Eka R
Published: October 2018

N/A
A Randomized FiveYear Comparative Study of Two LevonorgestrelReleasing Implant Systems: Norplant® Capsules and Jadena® Rods
Authors: Affandi Biran , Ridwan Rusdi S , Hoesni R Hasan M , Tandjung Thamrin , Ichsan TM , Amran Rizani , Manan Heriyadi , Gunardi Eka R , Pramana Noor , Hadiyono Suryo , Widohariadi Widohariadi , Farid Retno B , Taher Mardiah
Published: October 2018

Objective: To provide a randomized comparison between Jadena®

and Norplant® in terms of efficacy and acceptability among Indonesian

women.

Method: This study was a phase IV, open label, randomized, multicenter

study throughout Indonesia. Subjects were Indonesian adult

women who were randomized to receive Jadena® or Norplant® as

their contraceptive method. The subjects were recruited from 6

large cities in Indonesia, such as Medan, Palembang, Jakarta, Semarang,

Surabaya, and Makassar.

Result: Of 600 subjects, 301 women getting to Jadena® and 299

women to Norplant® were enrolled between August 1998 and

February 1999. The mean age was 29.8 (SD 5.3) years old, ranging

from 18 to 40 years old. We did not find the pregnancy during the

study. Non-pregnancy probability at the end of one year was similar

between Jadena® (0.920 (SD 0.016)) and Norplant® users (0.916

(SD 0.084)). The continuation rates of Jadena® at one and three-year

were 95.3% and 66.8%; whereas, the continuation rates of

Norplant® was 94.3% at year-1 and 70.2% at year-3.

Conclusion: The new two rod levonorgestrel subdermal system

(Jadena®) showed similar efficacy with the old six capsule

levonorgestrel subdermal system (Norplant®) in term of birth

control. Both implant systems also have similar tolerability profile.

Jadena® is easier to insert and remove than Norplant®.

Keywords: birth control, efficacy, implant
Implementation of Soft-Lithography Techniques for Fabrication of Bio-Inspired Multi-Layer Dielectric Elastomer Actuators with Interdigitated Mechanically Compliant Electrodes
Authors: Corbaci Mert , Walter Wayne , Lamkin-Kennard Kathleen
Published: October 2018

Advancements in software engineering have enabled the robotics industry to transition from the use of giant industrial robots to more friendly humanoid robots. Soft robotics is one of the key elements needed to advance the transition process by providing a safer way for robots to interact with the environment. Electroactive polymers (EAPs) are one of the best candidate materials for the next generation of soft robotic actuators and artificial muscles. Lightweight dielectric elastomer actuators (DEAs) provide optimal properties such as high elasticity, rapid response rates, mechanical robustness and compliance. However, for DEAs to become widely used as artificial muscles or soft actuators, there are current limitations, such as high actuation voltage requirements, control of actuation direction, and scaling, that need to be addressed. The authors’ approach to overcome the drawbacks of conventional DEAs is inspired by the natural skeletal muscles. Instead of fabricating a large DEA device, smaller sub-units can be fabricated and bundled together to form larger actuators, similar to the way myofibrils form myocytes in skeletal muscles. The current study presents a novel fabrication approach, utilizing soft lithography and other microfabrication techniques, to allow fabrication of multilayer stacked DEA structures, composed of hundreds of micro-sized DEA units.
Recursive Least Squares Filtering Algorithms for On-Line Viscoelastic Characterization of Biosamples
Authors: Di Giamberardino Paolo , Aceto Maria , Giannini Oliviero , Verotti Matteo
Published: October 2018

The mechanical characterization of biological samples is a fundamental issue in biology and related fields, such as tissue and cell mechanics, regenerative medicine and diagnosis of diseases. In this paper, a novel approach for the identification of the stiffness and damping coefficients of biosamples is introduced. According to the proposed method, a MEMS-based microgripper in operational condition is used as a measurement tool. The mechanical model describing the dynamics of the gripper-sample system considers the pseudo-rigid body model for the microgripper, and the Kelvin–Voigt constitutive law of viscoelasticity for the sample. Then, two algorithms based on recursive least square (RLS) methods are implemented for the estimation of the mechanical coefficients, that are the forgetting factor based RLS and the normalised gradient based RLS algorithms. Numerical simulations are performed to verify the effectiveness of the proposed approach. Results confirm the feasibility of the method that enables the ability to perform simultaneously two tasks: sample manipulation and parameters identification.
Opening the “Black Box”. Factors Affecting Women’s Journey to Top Management Positions: A Framework Applied to Chile
Authors: Kuschel Katherina , Salvaj Erica
Published: October 2018

The issue of women’s participation in top management and boardroom positions has received increasing attention in the academic literature and the press. However, the pace of advancement for women managers and directors continues to be slow and uneven. The novel framework of this study organizes the factors at the individual, organizational and public policy level that affect both career persistence and the advancement of women in top management positions; namely, factors affecting (1) career persistence (staying at the organization) and (2) career advancement or mobility (getting promoted within the organization). In the study location, Chile, only 32 percent of women “persist”, or have a career without interruptions, mainly due to issues with work–family integration and organizational environments with opaque and challenging working conditions. Women who “advanced” in their professional careers represent 30 percent of high management positions in the public sector and 18 percent in the private sector. Only 3 percent of general managers in Chile are women. Women in Chile have limited access and are still not integrated into business power networks. Our findings will enlighten business leaders and public policy-makers interested in designing organizations that retain and promote talented women in top positions.
Impact of Genetic Background on the Leaf-Protective Enzyme Activity and Hormone Levels of Maize
Authors: Liu Chunxiao , Li Zongxin , Liu Tieshan , Zhang Hui , Zhao Haijun , Wang Qingcheng , Shi Yonghui , Dai Hongcui , Liu Kaichang
Published: October 2018

The delay of leaf senescence, also known as the stay-green (SG) phenotype, is a trait closely associated with yield gain and resistance to many biotic/abiotic stresses. In order to increase the stress tolerance in maize, eight genetic background types were compared against the hallmarks of delayed senescence. The plant redox status and hormonal levels were tested among widespread SG and non-SG (NSG) maize lines in northern China. We found that SG maize lines showed greater activity of the reactive oxygen species (ROS) scavenging apparatus including leaf superoxide dismutases (SOD), peroxidases (POD), and catalases (CAT). Moreover, the concentration of malonaldehyde (MDA), a membrane lipid peroxidation marker, was significantly lower in SG than in NSG plants. For the hormone content, SG maize lines showed higher zeatin (ZR) and lower abscisic acid (ABA) after silking, resulting in a higher ZR/ABA ratio. Understanding the correlation between the stay-green trait and the corresponding hallmarks of delayed senescence is an important step in promoting SG to increase yield and stress tolerance. Our findings provide valuable insight into how to promote the SG trait in specific maize lines to increase yield and stress tolerance.
Cytoprotective Effects of Natural Compounds against Oxidative Stress
Authors: Mehta Jay , Rayalam Srujana , Wang Xinyu
Published: October 2018

Oxidative stress, an imbalance between reactive oxygen species and antioxidants, has been witnessed in pathophysiological states of many disorders. Compounds identified from natural sources have long been recognized to ameliorate oxidative stress due to their inherent antioxidant activities. Here, we summarize the cytoprotective effects and mechanisms of natural or naturally derived synthetic compounds against oxidative stress. These compounds include: caffeic acid phenethyl ester (CAPE) found in honey bee propolis, curcumin from turmeric roots, resveratrol abundant in grape, and 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), a synthetic triterpenoid based on naturally occurring oleanolic acid. Cytoprotective effects of these compounds in diseases conditions like cardiovascular diseases and obesity to decrease oxidative stress are discussed.
No-Reference Blurred Image Quality Assessment by Structural Similarity Index
Authors: Zhang Haopeng , Yuan Bo , Dong Bo , Jiang Zhiguo
Published: October 2018

No-reference (NR) image quality assessment (IQA) objectively measures the image quality consistently with subjective evaluations by using only the distorted image. In this paper, we focus on the problem of NR IQA for blurred images and propose a new no-reference structural similarity (NSSIM) metric based on re-blur theory and structural similarity index (SSIM). We extract blurriness features and define image blurriness by grayscale distribution. NSSIM scores an image quality by calculating image luminance, contrast, structure and blurriness. The proposed NSSIM metric can evaluate image quality immediately without prior training or learning. Experimental results on four popular datasets show that the proposed metric outperforms SSIM and well-matched to state-of-the-art NR IQA models. Furthermore, we apply NSSIM with known IQA approaches to blurred image restoration and demonstrate that NSSIM is statistically superior to peak signal-to-noise ratio (PSNR), SSIM and consistent with the state-of-the-art NR IQA models.
Real-Time Whole-Body Imitation by Humanoid Robots and Task-Oriented Teleoperation Using an Analytical Mapping Method and Quantitative Evaluation
Authors: Zhang Zhijun , Niu Yaru , Yan Ziyi , Lin Shuyang
Published: October 2018

Due to the limitations on the capabilities of current robots regarding task learning and performance, imitation is an efficient social learning approach that endows a robot with the ability to transmit and reproduce human postures, actions, behaviors, etc., as a human does. Stable whole-body imitation and task-oriented teleoperation via imitation are challenging issues. In this paper, a novel comprehensive and unrestricted real-time whole-body imitation system for humanoid robots is designed and developed. To map human motions to a robot, an analytical method called geometrical analysis based on link vectors and virtual joints (GA-LVVJ) is proposed. In addition, a real-time locomotion method is employed to realize a natural mode of operation. To achieve safe mode switching, a filter strategy is proposed. Then, two quantitative vector-set-based methods of similarity evaluation focusing on the whole body and local links, called the Whole-Body-Focused (WBF) method and the Local-Link-Focused (LLF) method, respectively, are proposed and compared. Two experiments conducted to verify the effectiveness of the proposed methods and system are reported. Specifically, the first experiment validates the good stability and similarity features of our system, and the second experiment verifies the effectiveness with which complicated tasks can be executed. At last, an imitation learning mechanism in which the joint angles of demonstrators are mapped by GA-LVVJ is presented and developed to extend the proposed system.
Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan
Authors: Alfaqih Mahmoud A. , Al-Mughales Faheem , Al-Shboul Othman , Al Qudah Mohammad , Khader Yousef S. , Al-Jarrah Muhammad
Published: October 2018

Type 2 diabetes mellitus (T2DM) is a worldwide health problem caused by resistance to insulin action. This chronic debilitating diseaseis preceded by a stage, known as prediabetes, in which a healthy lifestyle can delay the disease. The discovery of biochemical changes in prediabetes is important to identify individuals at risk of developing T2DM and in explaining disease pathogenesis. Adiponectin is secreted by fat cells and is linked with insulin resistance. Adiponectin levels are dysregulated in prediabetic subjects. This relationship had not been tested in Jordan. We recruited 130 subjects with prediabetes and 130 control subjects. We measured serum levels of adiponectin and genotyped subjects for three single nucleotide polymorphisms (SNPs) in the ADIPOQ gene; rs266729, rs1501299 and rs2241766. In multivariate analysis, we found that serum adiponectin lowers the risk of prediabetes (p = 0.002; odds ratio (OR), 0.764; 95% confidence interval (CI), 0.646–0.905). The rs1501299 SNP of the ADIPOQ gene was associated with prediabetes in our population (p = 0.041). Specifically, in multivariate analysis, the GT genotype of rs1501299 increased the risk of prediabetes (p = 0.010; OR, 2.350; 95% CI, 1.231–4.486) as well as the TT genotype (p = 0.006; OR, 4.774; 95% CI, 1.551–14.693). Our findings indicate that serum adiponectin and SNPs in the ADIPOQ gene are associated with prediabetes in Jordan.
Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization
Authors: Turcotte Stéphane , Mellal Katia , Chingle Ramesh , Mulumba Mukandila , Omri Samy , Dif-Yaiche Lylia , Chemtob Sylvain , Ong Huy , Lubell William D.
Published: October 2018

Modulation of the cluster of differentiation-36 receptor (CD36) has proven promising for dampening pro-inflammatory macrophage signaling. For example, azapeptides (e.g., 1 and 2) bind CD36 selectively with high affinity, mitigate Toll-like receptor (TLR) agonist-induced overproduction of nitric oxide (NO), and reduce pro-inflammatory cytokine and chemokine production in macrophages. Moreover, semicarbazides 1 and 2 inhibit microvascular sprouting mediated through CD36 in the choroid explant. Seeking a selective CD36 modulator that mediated inflammation without influencing neovascularization, a set of azasulfurylpeptides (e.g., 3a–e) were synthesized in which the semicarbazide was replaced by an N-aminosulfamide residue using a novel solid-phase approach. Notably, azasulfurylpeptide 3c diminished selectively CD36-mediated TLR-2-triggered inflammatory response without affecting neovascularization. Subtle chemical modification at the peptide backbone from a carbonyl to a sulfuryl residue has had a selective effect on biological activity providing a valuable probe for studying CD36 chemical biology.