bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality assurance in the polytechnic of health, ministry of health
Authors: Darwis Darwis , Vellia Ade Sissca , Sumaryono Dino , Danim Sudarwan , Safnil Safnil , Kristiawan Muhammad
Published: October 2022

This research aims to see the strengths and weaknesses, differences and similarities of SPME standards, and build a hypothetical integration of quality assurance systems. This research type is evaluative research with a qualitative approach. The instrument is an interview guide, observation guide, and documentation. The data analysis used is a SWOT analysis, Mind Mapping, and CIPP. The results are the weaknesses are seen from multiple assignments, different assessment indicators, teamwork, implementation of the MOU has not been optimal, and the assessment period and data are not yet integrated. The threats are inconsistent regulations, different standards, and global competition. This is the first study that evaluated five accreditation quality assurance systems, ISO 9001: 2015, PDDikti, SAKIP, and ZI. The formulation of a hypothetical model provides SPMI data for the requirement of the SPME. The recommendation from this study is to coordinate the quality assurance center to synchronize the data and integrate data audit instruments in a quality assurance application.
Algoritmo para caracterizar agentes de innovación de la ciudad de México
Authors: García-Jarquín Brenda , Aguilar-Fernández Mario , Salgado-Escobar Graciela
Published: October 2022

La innovación y el cambio tecnológico son el motor de la competitividad nacional, del desarrollo y el crecimiento económico a largo plazo. En este documento se construyó un modelo de dinámica de sistemas para generar tres series de tiempo sobre índices de innovación futuros (2014-2024) en empresas mexicanas de: productos, procesos y productos-procesos. Los resultados obtenidos indican la existencia del comportamiento de escalamiento dinámico tipo ansatz de Family-Viscek para la cinética de rugosidad de una interfaz en movimiento. Por lo tanto, se espera que la dinámica de los índices de innovación de empresas manufactureras, en la Ciudad de México y en México, sea descrita y pronosticada por la ecuación tipo Langevin. Lo anterior puede ser un soporte robusto para que las autoridades gubernamentales mexicanas estén en mejores condiciones para analizar el impacto de las políticas de innovación, tanto a nivel local como nacional.
Use of automatic tensile testing machines for assessing the strength properties of packaging materials for baked confectionery products
Authors: Rossieva Daria , Reznichenko Irina , Ermolaeva Evgenia , Komarov Sergey , Surkov Igor
Published: October 2022

The authors conducted this study to assess the influence of the strength properties of packaging materials for baked confectionery products on the tensile strength, fracture strength, and elongation level. The purpose of this study was to evaluate the mechanical properties (impact strength, fracture strength, and distance to fracture). The paper presents a brief overview of modern methods of functional and operational properties control for polymer packaging materials used for food products and describes their features. The objects of the study were samples of packaging for gingerbread purchased from trade organizations. It has been shown that quality control of polymer packaging materials for food is key in determining the possibility of their intended use. The test results allow evaluating the possibilities and limitations, optimizing the technological process, and obtaining high-quality packaging. In conclusion, the authors give recommendations to gingerbread manufacturers to increase the competitiveness of the product and meet consumer demand.
New cryoscopic temperature determination technology for plant-based products
Authors: Korotkiy Igor Alekseevich , Neverov Evgeniy Nikolaevich , Korotkaya Elena Valerievna
Published: October 2022

The determination of cryoscopic temperature is an important parameter in the calculation of low-temperature processing modes of frozen products. The process of rapid freezing is accompanied by temperature changes, therefore, to develop energy-saving and effective methods of preserving and processing fruit and berries, it is necessary to accurately determine some variables that affect the result of freezing. The study aimed to develop a differentiated analysis technique for determining the cryoscopic temperature and the crystallization temperature of the eutectic points of sucrose and glucose solutions. To determine the cryoscopic temperatures in the study, the method of thermal analysis based on the construction of freezing thermograms was used. The study was conducted using berries grown in the Kemerovo region (Russia). As a result of the study, it was found that the cryoscopic temperatures were most influenced by the total (free and bound) moisture content and organic and mineral substances in berry juices. The authors also determined cryoscopic temperatures of different black currant, sea buckthorn, and juneberry varieties. The developed technique will allow for the simulation of freezing processes under various processing conditions.
Meningkatkan kemampuan komunikasi dan kepercayaan diri siswa melalui program CERIA cerita anak di kelas IV
Authors: Subanindro Subanindro
Published: October 2022

Kemampuan komunikasi dan kepercayaan diri murid dapat ditingkatkan melalui program CERIA Cerita Anak. Program ini rutin dijalankan sebelum jam pelajaran pertama dimulai sekitar 10 sd 15 menit. Para murid mendapatkan giliran sebagai pencerita didepan kelas sesuai jadwal yang telah mereka buat sendiri. Tema yang diangkat sesuai pilihan atau kesukaan murid.  Bahan cerita dapat dibuat sendiri atau berdasarkan buku cerita yang telah dibaca dari rumah. Cara menyampaikan cerita dapat langsung tanpa melihat bacaan. Namun demikian, bila ada murid yang masih kesulitan dalam penyampaian dapat menggunakan hasil gambar dalam suatu kertas. Guru yang mengawal di kelas dapat membantu menggali dengan bertanya terhadap apa yang dibaca murid. Diyakini dalam jangka panjang bila program ini dijalankan dengan disiplin dapat berdampak pada komuniaksi dan kepercayaan diri murid.
DENTAL CARIES MANAGEMENT IN YOUNG CHILDREN WITH INTERIM THERAPEUTIC RESTORATION
Authors: Sukma Novita , Soerachman Badi
Published: October 2022

Caries are the most common case in every individual, including children who are still at an early age. Caries in primary teeth can occur in the early period of tooth eruption, which begins with the presence of white spot lesions. Dental caries are known as Early Childhood Caries (ECC) at an early age. ECC is used for caries in primary teeth up to 71 months. Many factors trigger the occurrence of ECC. Early treatment is very important to prevent comprehensive damage. Usually, the operator will face conditions that are not conducive to treatment. Young children generally will behave uncooperatively, have very high mobility, cry, and have difficulty opening their mouths, so it will be difficult for the operator to give treatment. One of the most therapy is dental restoration. The treatment approach will depend on the severity of the case; treatment can be in the form of non-operative therapy, dental restoration, or the last stage extraction if the teeth cannot be maintained. This case report will discuss the treatment of primary tooth cavity lesions without pulp involvement in young children through Interim therapeutic Restoration (ITR) and strategies that need to be implemented to support the success of treatment and prevent the damage from worsening. The result showed that ITR wa successfully performed in young children with cooperative behavior to prevent more extensive tooth decay.
OVERVIEW OF BLIND-CHILDREN CARIES INDEX IN SPECIAL NEED SCHOOLS IN CIMAHI CITY
Authors: Sarwendah Sri , Hartman Henri , Alfin Muhammad
Published: October 2022

Blind people have limitations in receiving dental and oral health information. It can facilitate the occurrence of caries. Blind people have limitations in performing various activities that require vision assistance, such as maintaining oral and dental hygiene when brushing their teeth, so blind people often experience multiple problems with their teeth, one of which is caries. This study aimed to determine the caries index in blind children in SLBN A Cimahi City and SLBN A Bandung City. The study used a cross-sectional design and consecutive sampling. The number of samples was 21 blind children. The study's results on blind children aged 6-12 showed a very low to moderate caries index. The def-t index in children with low vision blindness has moderate criteria; in children with total blind blindness, it has low standards. Children with low vision and total blind have the same DMF-T index, which is low. The def-t index in SLBN A Citeureup Cimahi City has low criteria, while SLBN A Padjadjaran Bandung City has a def-t index with moderate standards. SLBN A Citeureup Cimahi City and SLBN, A Padjadjaran Bandung City, have the same DMF-T index, which is low. Parents, teachers, caregivers, and health workers need to pay more attention to the dental and oral health of blind children.
Preface: 2022 International Conference on Art Design, E-Education and Innovation Management (ADEIM 2022)
Authors: Tony Zachary , Sun Qilin
Published: October 2022

The South China University of Technology, Henan Normal University, University of Central Missouri and National University of Colombia jointly organize the 2022 International Conference on Art Design, E-Education and Innovation Management (ADEIM 2022). The conference is held at Dalian, China from June 25 to 26, 2022. It highlights recent and significant advances in research and development in art design, e-education, educational reform, humanities, innovation management and social science.

With participation of a large number of young researchers, ADEIM 2022 can be a platform for new collaborative ventures and strategic alliances to gain better insights into research and innovation to harness the strength and synergies to bring further prosperity to the nations. As the future becomes more competitive and challenging, it is important to remain relevant and maintain the performance for continuous improvement in research & education. It will also serve to facilitate the exchange of information between researchers and industry professionals to discuss the latest issues and advancement in these areas.

ADEIM 2022 brought together experts from different organizations to initiate discussions on topics that are of interest to the conference attendees. This conference provides the specialist's training and scientific research in these fields. Encouraging young researcher from multi-discipline background to share their new and innovative ideas and findings is the aim of the conference.

ADEIM Organizing Committee

Dalian, China
A Realistic Approach to Willa Cather’s My Antonia
Authors: Wang Ting
Published: October 2022

My Antonia is a famous book of Willa Cather. The book tells a story about the frontier life in the 19th century America centered around the Bohemian female protagonist Antonia. The essay begins by discussing language style, then moves to cultural conflicts, and finally focus on the social critiques on gender discrimination and immigration issue, to analyze how Willa Cather applies various elements to achieve realist writing style in this work.
On Strengthening the Education of "Four Histories" in the Course of "the Outline of Modern History of China"
Authors: Zhang Liqing
Published: October 2022

"Four Histories" are important resource and strong support of the "Outline" course while the "Outline" course is the main position to strengthen the "four histories" education. For strengthening the education of "Four Histories" in the "Outline" course, the premise is to grasp the logical relationship between theory, history and practice, as well as the relationship between time, space, content and primary and secondary contents while the key is to tell the stories of party history well, in particular, the ones of the party's centennial struggle course major achievements, the ones of important figures and important historical events, and the ones of the party's spirit, so as to realize the value guidance. In addition, we must adhere to the important principle of the combination of history and theory, and realize the unity of academic rationality and political nature.
Autopoiesis Crosses the Human-Machine Boundary——A Brief Analysis of the NPC Image in the Film-Game Integration Movie
Authors: Ding Junzhu
Published: October 2022

In recent years, with the development of popular culture and digital technology, there has been a new trend of fusion between online games and film art. In movies themed on popular games, some NPC images have developed self-awareness with the operation of artificial intelligence systems, they own the information body and the self-generating system, regarding human player as the mirror to self-identify and become a channel between the virtual and real worlds. These images play an important role in the narration, some of them resist system instructions in the climax of the story, not only break the original rules of the game, but also evolve new life forms, and challenge the authority of the traditional human-machine boundary for the acquisition of emotion, memory and thinking. The film's vivid interpretation of the NPC autogenesis process enriches the characters and expands the meaning of the theme, at the same time, it allows us to reflect on the contradictions and conflicts between humans, machines and other species from the perspective of virtual life, provides some inspiring opinions on how to meet the unknown posthuman future.
The Supreme Goodness is Like Water
Authors: Wei Yiwei , Ren Peinan , Wang Xiaoyi , Meng Qingxun , Dong Qingjiang
Published: October 2022

In China, there are mainly two philosophies that had tremendous impact on our civilization, which are Confucianism and Taoism. Taoism is the only belief system native to China, which had a grander perspective, about the relationship among the universe and human as well as human and human. The most important literature of Taoism is Tao Te Ching. The main doctrines of Tao Te Ching include: a natural state of being and Non-action.To Laozi, the way of water is completely different from the way of people with desire. As the source of life, water nourishes all living things on Earth. Water contributes to the world without regard for gain of loss. Remaining low, level, and quiet, water embraces and reflects everything under heaven. Water is invincible because it desires nothing and contends for nothing. It’s soft but not weak, instead, it’s full of strength. Water has three important virtues we can learn from, Which is “H2O”——humility, harmony and openness. The influence of Taoism lies in every single aspect of Chinese culture, such as traditional Chinese painting, music and Taiji(an ancient but popular Chinese self-defense art). Beyond that, Taoism has broken the boundaries of nations and attracted global attention and recognition. Of all ages, Taoist ideas have invested Chinese culture and art with a unique tone and an aesthetic beauty that emphasize inner spirit rather than outward forms.
The Road to Improving the Anti-addiction Mode of Short-video Software
Authors: Zhou Shiruo
Published: October 2022

In today's highly developed information technology, the fragmentation of information is becoming more and more common, which makes short videos popular as an efficient information delivery vehicle. Users of short videos include teenagers, who are at a critical stage in the formation of their outlook on life and are easily influenced by external information. For the sake of the healthy physical and mental development of teenagers, many short video software in the market have established teenager-specific modes to prevent them from becoming addicted to watching short videos. This report uses case studies and content analysis to examine the teenage model of DouYin, a software owned by ByteDance. The report analyses and recommends how the current teen mode achieves the desired effect, how it meets the psychological needs of adolescent users, and whether guardians can be completely at ease with their children's use of short video software because of the establishment of this mode. It gives clear opinions on the future path to improve the teen mode in the internet industry and suggests issues that need to be addressed. It is hoped that large Internet companies like ByteDance can make achievements in protecting young people and contribute to the education of society's next generation together with parents.
Study of ordering and transportation of raw materials for manufacturing companies based on 0-1 planning
Authors: Liu Jin , Chen Qinglong , Zhang Jinhong
Published: October 2022

The job functions of supply chain management is the planning and control of logistics related to the supply chain from the supplier to the production enterprise, specifically for the entire supply chain system of a manufacturing company, the various processes of planning, coordination, operation, control and optimization are carried out.  This paper focuses on quantitative analysis of the supplier's supply characteristics and solves the optimization problem by changing different constraints to establish predictive models for future pairs of ordering and forwarding solutions, respectively. Based on a quantitative analysis of the supplier's supply characteristics, this paper optimizes the total cost of delivering the right product to the right place, at the right time, in the suitable quantity, of the right quality and in the right condition, as required by the customer.
Contemporary College Students’ Views on Marriage
Authors: Li Boxi
Published: October 2022

The view of marriage, like the world outlook, is a tool for us to know and change the world. With the development of science and technology and economic society, some changes have taken place in people's views, especially in the young generation of students are more obvious, and college students are the best representative of the young generation. Therefore, in order to better understand the younger generation for marriage and the view of life, the paper randomly chosen from different regions, different family background and growth environment of college students, explore their views on marriage, love, and life, through our research, the survey also found some problems, The research on these issues can help us better understand the dynamic development of society for subsequent research.
Research on the Intention of College Students' Tourism Behavior under the Epidemic: Takes Xi'an Universities as an Example
Authors: Zhao Zixuan , Wang Xinxin , Hu Yidan
Published: October 2022

College students' tourism group has always been an indispensable market segment of the tourism market. In order to study the outbreak period of normalized college students 'tourism consumption behavior change, this paper adopts the questionnaire survey and depth interview, in xi'an university students as a sample, from the outbreak of the tourism behavior change, tourism behavior intention and may influence its behavior decision factor selection of three dimensions, with the method of mathematical statistical method analysis. Studies show that the consumption behavior, destination choice, travel time and frequency, and travel willingness of college students have all changed during the normalization of the epidemic. And from the government, tourism enterprises, college students themselves and other three dimensions put forward solutions.
How Can the Rule of Law Help Targeted Poverty Alleviation
Authors: Xu Lin
Published: October 2022

In the new era, poverty alleviation work is guided by precision poverty alleviation, with "true poverty alleviation and poverty alleviation" as its core. When implementing the targeted poverty alleviation policy, no matter from the precise identification or assistance measures and the setting of the assessment mechanism, specific legal guidelines are needed. Poverty reduction by the rule of law can not only make precision poverty alleviable by law, but also enable citizens to safeguard their due rights through the law. At the same time, poverty reduction by the rule of law has higher requirements for the legal literacy of poverty alleviation workers in order to better implement " Seek truth from facts and adapt to local conditions."
Digital Transformation: A Review and Research Framework
Authors: Ji Xiaoli , Li Weiqing
Published: October 2022

Extant literature has increased our understanding of specific aspects of digital transformation, but we lack a comprehensive portrait of its nature and implications. Through a review of works at home and abroad, we conclude the meaning of digital transformation from the technical and value dimensions, and then elaborate the concept of digital transformation from the perspective of the strategic change process. The TOE framework is used to analyze the impact of relevant factors on digital transformation in three dimensions: technology, organization and environment. We inductively build a framework of digital transformation basing on the analysis of the connotations and theoretical perspectives of digital transformation. Finally, taking into account the shortcomings of the existing digital transformation literature, we propose relevant research directions on digital transformation.
The Influence of the Development of Digital Economy on the Structural Upgrading of Manufacturing Industry in China
Authors: Zhao Qingmu
Published: October 2022

Throughout the process of global industrial change, technological progress has been the core decisive force. Every technological progress has been accompanied by a substantial increase in productivity, and realized the transformation and upgrading of traditional industries through the deep integration of technological innovation and traditional industries, forming a new industrial form. At present, China is in the critical stage of economic structural transformation. Digital economy, as a new economic form, provides new opportunities for the transformation and upgrading of manufacturing industry. The configuration effect of the digital economy not only changes the way of knowledge acquisition, but also improves the efficiency of factor allocation, which can bring significant economic effects. Therefore, it is of great significance to seize the opportunity of the new round of digital technological revolution to realize the transformation and upgrading of manufacturing industry.
Analysis of the Characteristics of Mobile Audio Payment Platform
Authors: Mei Jie
Published: October 2022

With the popularization and development of the Internet and mobile devices, the forms of knowledge production and dissemination are increasingly rich. Mobile paid audio platform has become one of the carriers of high-quality content due to its fragmentation, accompanying, social and other characteristics. As the largest mobile paid audio platform in China at present, Himalayan FM adopts the content production mode of "UGC+PGC+exclusive copyright" in terms of program content. The audio program content is mainly "fast, short and flat", which is more in line with the current fragmented scene environment. In 2016, the Himalayan FM took the lead in trying to produce and disseminate knowledge-based audio pay programs, creating a premium pay program zone, and playing a leading role in the mobile pay audio field. Although Himalayan FM is the "leader" of mobile pay audio platform, there are also some problems that must be solved in the development. Therefore, understanding its characteristics can provide some suggestions for the future development of Himalayan FM.
Analysis of the Management of Small and Medium Rivers in Urban Area Based on Ecological Civilization Construction of Waters
Authors: Feng Tongyue , He Qing , Mei Huan
Published: October 2022

Water is the soul of the city, people in the early construction of the city is based on water, all the major cities today are river through. Rivers are closely related to the development of towns. As one of the indispensable and important substances for the survival and development of human beings, the study of water resources plays a great role in the construction of ecological civilization in cities. However, the problem of sewage discharge is still prevalent in small and medium-sized cities. Even though the country has spent a lot of money in recent years to deal with water pollution and implement measures to treat rivers whose ecological environment has been destroyed, the problem of sewage discharge cannot be solved fundamentally. Based on the research on moon lake in Chizhou, Anhui province, this paper holds that the restoration of urban small and medium-sized rivers should be based on the restoration of high-quality water resources, put forward the strategy of systematic management, ecological priority, improve the comprehensive benefits of urban small and medium-sized rivers, give full play to the role of effective supervision by residents, and build a new ecological civilization in the water areas. Based on the shortcomings and experience gained from the treatment of moon-lake sewage in Chizhou city, we will popularize the treatment of urban river wastewater from small to large, take the improvement of water environment as an important part of ecological management, find out the problems in the process of water environmental management and put forward corresponding measures to establish scientific and efficient protection mechanism.
Research on the Construction of Marketing Mode of Agricultural Products in Hunan Province under the Environment of “Internet +”
Authors: Tang Jiangting
Published: October 2022

Implementing the rural revitalization strategy is an inevitable requirement for solving the contradiction between the people’s ever-growing needs for a better life and unbalanced and inadequate development. At present, Internet technology is accelerating the extension and penetration of agriculture and rural areas, and has achieved remarkable results in agricultural technology promotion, market information services, agricultural and rural e-commerce, precision poverty alleviation and other aspects. Agricultural Internet of things and big data also show very broad application prospects. Hunan, as the hometown of fish and rice and a large agricultural province, is an important national food production base and high-quality agricultural product supply base, which has assumed great responsibility in ensuring national food security. Therefore, the “Internet + agricultural products” marketing of Hunan Province is the key to achieving rural revitalization.
Preface: 2022 International Conference on Modern Medicine Technology and Clinical Science (MMTCS 2022)
Authors: Whitman Deirdre , Liu Huiyan
Published: October 2022

We are glad to introduce you that the 2022 International Conference on Modern Medicine Technology and Clinical Science (MMTCS 2022) was successfully held during July 23-24, 2022 in Dalian, China. Considering that the worldwide travel restriction and the impact of COVID-19, this conference was carried out in the virtual form to avoid personnel gatherings. Because most participants were still highly enthusiastic about participating in this conference, we chose to carry out via online platform according to the original schedule instead of postponing it.

MMTCS 2022 brought together innovative academics and industrial experts in the fields of modern medicine technology and clinical science and applications to a common forum. The primary goal of the conference is to promote research and developmental activities, and another goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working all around the world. The conference will be held every year to make it an ideal platform for people to share views and experiences in related areas.

This scientific event brought together more than 70 national and international researchers. During the conference, the conference model was divided into three sessions, including oral presentations, keynote speeches, and online Q & A discussion. All the papers have been processed to meet the requirements of international publication standard. We selected a bunch of high-quality papers and compiled them into proceedings after rigorously reviewing.

We would like to express our sincere gratitude to the distinguished keynote speakers, as well as all the participants. We also want to thank the publisher for publishing the proceedings. May the readers could enjoy and gain some valuable knowledge from the MMTCS 2022 proceedings. We are expecting more and more experts and scholars from all over the world to join this international event next year.

The Scientific Committee of MMTCS 2022

Dalian, China
Recent Blood and Intracranial Molecular Biomarkers to Moderate Depression and Major Depressive Disorder
Authors: Zhong Yafei
Published: October 2022

Depression, especially moderate depression and MDD, brings huge pressure and loss to patients and society through a series of symptoms. However, the current diagnosis of depression is short of objective, quantifiable, and absolute detection techniques. If we can find specific depression molecular biomarkers and high-sensitivity and high-accuracy molecular biomarker detection technology, it can help patients with depression to diagnose and predict earlier. In this paper, the heterogeneous biomolecules of depression are classified into intracranial markers and blood markers, and the biomolecules with representative value are listed. Meanwhile, it analyzes and compares the current popular biological detection technologies, IHC and RNAscope. If the heterogeneous depression biomarkers can be detected by the combination of IHC and RNAscope technology, the accuracy and timeliness of depression diagnosis will be greatly improved, and lay the groundwork for better depression treatments in the future.
The Impact of Notch Pathway on The Occurrence and Development of Cancer
Authors: Zhao Shangshang
Published: October 2022

The Notch pathway (NP) controls the growth and development of organisms through intercellular interactions, and is highly conserved. NP extensively affects human life activities. It has an involvement in a range of cellular processes, including the process of the differentiation and proliferation. For example, the normal development of neuronal cells, germ cells and sensory cells in living organisms depends on Notch-mediated inhibition of differentiation. Neurological growth, organ formation, immune system and tumorigenesis are also dependent on NP. Furthermore, available studies show that NP is critical not only in tumorigenesis and progression, but also in prognosis. Currently, the NP has become a hotspot for research in several fields. This article describes some of the roles played by the NP in the nervous system, organogenesis, and immune system. Some of the research advances in tumors related to NP are collated, and the research on the impact of interventions targeting Notch pathway on cancer treatment is summarized.
The Risk factors of Osteoarthritis
Authors: Yan Yi Lin Hong
Published: October 2022

Osteoarthritis (OA) is the one type of arthritis which affects 7% of the population and is the 15th leading cause of disability. However, the etiology of this disease is complex and its pathogenesis is still under investigation. The pathological changes seen in OA most commonly include synovitis, osteophyte formation, cartilage degradation, thickening of the subchondral bone, etc. which may lead to symptoms such as stiffness, movement disorder and swelling. OA generally starts with the damage of the articular cartilage of the synovial joint which later leads to a cascade of effects that ultimately leads to joint destruction. Some of the identified risk factors of OA include old age, gender, genetics, obesity, and neurological disorder. However, even with these factors being identified, many of the mechanisms responsible for progression to OA behind these risk factors remain unclear. This paper reviews different articles regarding the risk factors of OA and summarizes the possible mechanisms behind each risk factor.
Comparison of the treatments of osteoarthritis
Authors: Dai Siqi
Published: October 2022

Osteoarthritis is one of the most prevalent diseases in the world, which affects a wide range of age groups, ranging from children to the elderly. More than 300 million people worldwide suffer from osteoarthritis, which may cause pain, stiffness, tenderness, loss of flexibility, grating sensation, bone spurs and swelling, and other diseases. Medication, surgery, and therapy are the main treatments. For medication, there are Analgesics and Nonsteroidal anti-inflammatory drugs, which have the function of reducing pain and inflammation. Nonsteroidal anti-inflammatory drugs can also reduce pain. For surgery, there are arthroplasty, arthrodesis, and osteotomy. In addition, there are physical therapy and occupational therapy. Those different kinds of therapies have their own advantages. Recent studies have shown that mesenchymal stem cells (MSCS) can be used to treat osteoarthritis, which has the properties of differentiating into chondrocytes and having anti-inflammatory and immunomodulatory effects. These cells are ideal for treating osteoarthritis that requires anti-inflammatory and cartilage replacement. This paper provides a brief overview of the different treatment approaches and aims to compare the pros and cons of each approach.
Research progress on the correlation between sacubitril-valsartan and cognitive function in hypertensive patients
Authors: Ma Junni , Li Ruining
Published: October 2022

Sacubitril-valsartan can exert antihypertensive effects by blocking the effect of angiotensin Ⅱ and inhibiting the activity of enkephalinase. As a currently common antihypertensive drug, sacubitril-valsartan’s protective effects on target organs have been confirmed in more and more studies. Inhibition of enkephalinase can hinder the degradation and metabolism of beta-amyloid, deposition of which is a characteristic pathological feature of Alzheimer's disease. And hypertension itself is a risk factor for cognitive dysfunction, so long-term medications have the theoretical possibility to result in adverse effects on the cognitions of hypertensive patients. A review of various perspectives towards the effects of sacubitril-valsartan on cognitive function in patients with hypertension will be delivered.
BRAF gene mutation and papillary thyroid carcinoma
Authors: Zhang Junru
Published: October 2022

Nowadays, Thyroid carcinoma (TC) is the most common malignant tumor of endocrine system, accounting for about 1% of the malignant tumors in the whole body, ranking first in the head and neck malignant tumors. Papillary thyroid carcinoma (PTC) is a malignant tumor originated from thyroid follicular epithelial cells, which is the most common pathological type in TC. V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) is a molecular biological marker for the diagnosis and prognosis of PTC and a target gene for the treatment of PTC. Its gene mutation is a hot point in the TC research field. The most common gene mutation is BRAF V600E mutation and it is a molecular marker in PTC. With the deep-going of its research, contradictions and controversies about the relationship between BRAF V600E and PTC gradually emerge. Many molecular targeted drugs targeting BRAF gene are also being continuously researched and some achievements have been made. This review mainly expounds the relationship between BRAF V600E and clinicopathological features, analyzes and expounds the controversial parts currently as well as show the research status of molecular targeted drugs.
Influencing factors and intervention therapy of the Autism Spectrum Disorder (ASD)
Authors: Huang Ruwei
Published: October 2022

Autism spectrum disorder (ASD) is a kind of the disorder which is characterized by continuous social interaction and communication disorders, narrow interests and repetitive stereotyped behaviors are the main core symptoms of neurodevelopmental disorders. At the same time, the incidence of the disease increases rapidly and is extremely harmful, which brings huge economic burden to families and society. Therefore, early identification and early intervention are urgently needed. At present, the pathogenesis of ASD is not clear, and there is no perfect diagnostic tools and methods. So far, scholars are still exploring the etiology and pathogenesis of ASD. In the past, researchers have paid attention to the study of twins and found that the prevalence of monozygotic twins is higher than that of dizygotic twins, so as to try to explain the ASD from a genetic perspective.Academic circles generally believe that ASD is caused by the joint action of genetics and environment. In order to find the objective indicators of early recognition of ASD individuals, researchers have actively carried out research on ASD infants, such as twins, the overall processing of isolated faces,event-related potentials (ERP) and other monitoring methods. Traditional ASD psychotherapy mostly focuses on behavioral rehabilitation training, supplemented by some drug treatment.Advanced spatial information technology has certain advantages and potentials for the treatment of autism spectrum disorders.However, at present, the research in this field is relatively scattered and cannot be popularized.
A Review of Sleep Process and Influencing Factors
Authors: Jin Zhangnan
Published: October 2022

In modern society, people often have difficulty in sleeping because of various reasons including psychological or physiological factors, environment, life rhythm and diet. This paper illustrates this effect by integrating various surveys. According to clinical trials, insomniacs normally share common characteristics such as poor sleep habits. In this essay, the main structure of sleep will be first introduced in detail, namely NREM and REM. Then it will discuss certain elements that affect sleep patterns, together with proper improvement methods. While these statistics are based on the majority of people, they don't necessarily apply to everyone. If the phenomenon that the sleep quality is poor exists for a long time, it is advisable to seek medical assistance. Additionally, the importance of both the number of awakenings and the quality of breathing in assessing sleep quality together with some reasonable advice will be put after description of sleep process.
Predict the Therapeutic Effect of Bevacizumab Treatment Using a Channel Attention Convolution Neural Network
Authors: Xu Hongtao
Published: October 2022

One of the malignancies with the highest mortality rates among women worldwide is ovarian cancer. Epithelial ovarian cancer (EOC) is the most common kind of ovarian cancer which takes ~90% of ovarian cancer patients. peritoneal serous surface papillary carcinoma (PSPC) is rare cancer whose incident rate is 7% in women. Bevacizumab has been used as a monotherapy along with chemotherapy to treat advanced EOC and PSPC. Bevacizumab has a significant effect on chemotherapy, however, due to the high cost and side effects of the bevacizumab, how to predict the therapeutic effect of Bevacizumab treatment is very important. In this paper, the author uses the proposed attention module, ECA, embedding to the ResNet, compose as ECA-Net, to predict the treatment effect of the bevacizumab in current tissue is effective or invalid through the histopathological image. As a result, the ECA-Net gained novel performance, scoring highly on several evaluation metrics. Specifically, the classification accuracy of the ECA-Net is 94.54% and the f1 score is 95.00%. Bevacizumab is pricey and has side effects, the classification model will forecast its therapeutic impact. In this situation, the experiment will assist the gynecologist in selecting the best course of therapy while also saving money.
Effects of Dietary Rumen-Protected Choline Supplementation on Colostrum Yields, Quality, and Choline Metabolites from Dairy Cattle
Authors: Lyu Zhouyao
Published: October 2022

Choline is a kind of important and necessary nutrient for many animal species, which is always supplemented in the diet in order to support the postpartum health and production performance of periparturient dairy cows. Although choline and its metabolites have been characterized in milk, the effects of dietary rumen-protected choline (RPC) supplementation on choline metabolites in colostrum haven’t been explored. Recently, the effects and dose of dietary RPC supplementation on colostrum yields, quality and choline metabolites have been explored. Cows with three different doses of choline ions indicated that adding dietary choline can increase the amount of colostrum without affecting the quality of colostrum. In addition, dietary choline supplementation increased phosphocholine concentrations from cows calving for the second time. However, it had no effect on phosphocholine concentrations in colostrum from older cows, which suggested that there may be parity preference for choline metabolic pathways. Finally, dietary choline supplementation increased trimethylamine N-oxide concentrations.
Molecular diagnosis of Alzheimer’s disease
Authors: Lin Xingyu
Published: October 2022

Since the beginning of time, Alzheimer's disease has been a major issue, which is a neurodegenerative disease which would cause to death. It involves both chronic and acute neurodegenerative. For treating these illnesses, there are few or no potential curative treatment options that are effective. The traditional diagnosis is invasive and people with AD can only treat by drugs, which is for relieve some of the symptoms. Therefore, early diagnosis is considered to be the key factor for prevention and treatment, and it has been gained more attention. Nowadays, it is one of the key topics of current research. Scientists have developed plenty of probes based on different compound, it has an incredible improve when using on the mice, however, it is still a big challenge to validate in human brain.
Well-Designed Smartphone-Based Imaging Biosensor
Authors: Ding Jierui
Published: October 2022

With the development of hardware and software for smartphones, more and more well-designed smartphone-based imaging biosensors have been created and broadly applied in point-of-care testing (POCT). Imaging biosensors can get clear images through the high pixel density of smartphones’ camera systems. And smartphones also provide a chance for imaging processing thanks to smartphones' central processing units (CPUs) and graphics processing units (GPUs). Different approaches have extensively explored smartphone-based imaging biosensors. The commonly used imaging methods are generally implemented by the bright field with the light source or by fluorescence with a fluorescence microscope. Smartphones have enabled the widespread application of imaging-based methods in clinical chemistry, environmental monitoring,  flow cytometry, food analysis, drug screening, and medical diagnostics. In detail, this article discusses various imaging biosensors and specific applications of smartphone-based imaging biosensors for bright-field imaging and fluorescence bioimaging. Meanwhile, the opportunities and challenges of smartphone-based imaging biosensors are also analyzed here.
CAR-T therapy in Acute lymphocytic leukemia
Authors: Lin Weichiao , Wu Jiarui
Published: October 2022

Acute lymphocytic leukemia is a serious threat to people’s health. For a long time, the main therapy to cure the cancers include surgery and chemotherapy, but the traditional therapy still has some limitations and the side effect after treatment will seriously affect the quality of life. CAR-T has gradually become a new treatment to cure ALL.CAR-T cell which is through gene engineered T cell to carry the scFV. Then the engineered T cell can specific recognition the antigen and kill the tumor cell. But with the application of CAR-T, there are more and more problems show up, such as the safety, efficiency and relapse. This review discussed the mechanism and applications of CAR-T in acute lymphocytic leukemia and introduce the advantage of CAR-T and some limitations and future development.
Immune Checkpoint inhibitor Therapy in Various Cancers
Authors: Sun Yining , Wang Nan , Zhang Nuo
Published: October 2022

Immune checkpoint inhibitors (ICIs) are a new way of immunotherapy, not simply refers to the improvement of immunity to the body, but by improving the immune microenvironment around the tumor, thereby activating immune cell activity in vivo to achieve anti-tumor purposes. Now, CTLA‐4 and PD‐1 or PD‐L1 monoclonal antibody are mainly developed relatively successfully for immune checkpoints, in addition to other new immune checkpoints that have been discovered and clinically tested. However, while immune checkpoint inhibitors have been developed successively, some vague problems still need to be solved, such as the large gap between the immunotherapy effects of different patients. These issues are critical to the selection of immune checkpoint inhibitors. In this review, based on the study of the immunosuppressive mechanism of CTLA-4 and PD-1/PD-L1, the application of related immune checkpoint inhibitors in cancer treatment is discussed starting from three representative types of cancer. At the same time, according to the existing problems, some common immune-related adverse events and newly discovered immune checkpoints are summarized, and the future research direction of ICIs is further explored.
CAR T cell-induced systemic cytokine toxicity: current understanding and innovative designs
Authors: Yang Zhaoqi
Published: October 2022

CARs engineering has emerged as a promising treatment for tumor. However, CAR T cell-induced systemic cytokine toxicity is one of the roadblocks limiting the widespread application of the therapy. Current study contributes to some toxicity-related monitoring and management guidelines. Researchers have further developed novel engineering strategies to produce inducible CARs and passively or autonomously control CAR T cells. This review described the recent bench and clinical outcomes of novel engineering CAR T-cell products and discuss their function, advantages, and limitations.
Feasibility study of VR immersion technology in psychotherapy
Authors: Luo Guangli , Yin Jun , Luo Yiwei , Liu Kaiyan , Deng Ting , Hao Tongxi
Published: October 2022

The research object of this paper is the innovation of the application mode of VR immersion technology in psychotherapy. This paper put forward relevant optimization policies through the discovery of the problems existing in the application process of VR immersion technology in psychotherapy. First of all, the background of VR immersion technology and the status quo of the technology in psychotherapy are discussed. And then the importance of VR technology in psychotherapy is deeply analyzed. Based on the above content, the problems existing in the application of VR technology in psychological aspects are put forward and including the shortage of applied talents and the insufficient application of VR social psychotherapy services. Finally, on the basis of finding these problems, this paper puts forward some targeted optimization strategies.
Investigation of Ionospheric Disturbance and Seismic Events Based on Machine Learning
Authors: Long Yanchen , Zhang Qinghui , Dai Zhengquan , Rong Jian
Published: October 2022

Earthquakes are natural disasters that endanger human life and cause the greatest loss of property. The study of anomalous disturbance of the ionosphere, one of the pre-earthquake anomalies, will help to further study the coupling effect on the ionosphere before the earthquake. This paper focuses on the analysis of the importance and influence of various parameters inside the seismic ionosphere under earthquake conditions, constructs a classification and prediction model of seismic ionospheric anomalies based on the gradient boosting decision tree GBDT algorithm, and analyzes the pre-earthquake ionospheric data. , the results show that NmE, nHe+, foF2 and TEC are important influencing factors, which lays a certain foundation for the further study of the internal structure and parameters of the pre-earthquake ionosphere