bluuebunny/crossref_metadata_2025 huggingface dataset:
POTENTIALS OF IMPLEMENTATION OF SHARIA PRINCIPLES IN THE TOURISM SECTOR OF BATU CITY,EAST JAVA
Authors: Zaki Irham , Hamida Gautsi , Cahyono Eko Fajar
Published: March 2020

The main objective of this research is to see the potential that supports the implementation of sharia principles in the Batu City tourism sector. The tourism sector studied consists of hotels, restaurants and food, travel agencies and tourist areas. The next objective is to see the economic benefits that will be produced in the future with the application of sharia principles in the tourism sector. This study uses descriptive qualitative methods conducted by interviews, observations and questionnaire tools to see the response generated through a Likert scale. The results of this study indicate that parties related to the tourism sector provide a positive response to the application of sharia principles in the tourism sector, which will provide economic benefits for industry players, the public, and the government.
Diagnostic screening of HPV genotypes in 555 Ecuadorian mestizo women of seven provinces, and comparison with other Latino American populations
Authors: González Andrade Fabricio , Torres Serrano Carlos , Pinos Jakeline , Grijalva María de Carmen , Aguinaga Romero Gabriela
Published: March 2020

Objective: this paper aims to perform diagnostic screening of HPV in healthy Ecuadorian mestizo women, from seven provinces, and compare the findings with other Latin American populations. Material and methods: genotyping was done with two different oligonucleotides MY09 and MY11; a fragment of 450 base pairs was amplified, L1 region of the viral genome. Results: it analyzed 555 women, 35 were positive for HPV (6.3%). Genotypes found in relation to oncogenic risk, were 6, 11, 16, 18, 31, 33, 35, 42, 45, 51, 52, 53, 58, 59, 61, 81. 12/35 women (34.3%) presented high-risk genotypes. Four positive cases were also observed in women older than 55 years (0.36%). The 14 published studies of Ecuadorian women showed that the most prevalent genotypes are 16, 18, 31, 52, 53, 56 and 58; while in the eight Latin American Studies the most prevalent are 16, 18, 31, 45, 52 and 58. Conclusion: although there are several studies on HPV genotyping on Latin American populations, there is an important gap related to ethnicity and the prevalence of the virus. In addition, most of them have not compared similar and common subtypes in the population. The general prevalence of HPV in the studied population was 6.3%. It found that genotypes 16, 18, 31, 52, 53, 56 and 58 are the most prevalent in Ecuadorian normal mestizo women. Genotypes 53 and 56 are common in Latino populations. Larger studies, in different ethnic groups are needed to identify other prevalent genotypes in certain geographical areas.
Envejecimiento neural, plasticidad cerebral y Ejercicio: Avances desde la óptica de Fisioterapia
Authors: Pinzón Ríos Iván Darío , Moreno Collazos Joege Enrique
Published: March 2020

El ejercicio ha demostrado efectividad para promover la plasticidad cerebral en los procesos de envejecimiento neural. Esta revisión narrativa de literatura tiene como objetivo analizar el efecto neural del ejercicio para promover la plasticidad cerebral en el envejecimiento. Los resultados incluyeron publicaciones que mencionan los efectos de la plasticidad cerebral mediada por el ejercicio, mediante protocolos de ejercicio con duración, intensidad y frecuencia clínicamente significativa. Mediante la revisión documental se determinaron tres apartados: Envejecimiento Neural: Procesos fisiológicos interrelacionados; Plasticidad cerebral mediada por el Ejercicio; Ejercicio para promover el envejecimiento neural saludable. Se pudo concluir que el fisioterapeuta, aplicando protocolos de ejercicio, puede promover cambios positivos en la función cerebral lo cual se traducen en la mejoría del desempeño físico y funcional de los adultos mayores.
VO2 Estimation Equation Accuracy to Young Adults
Authors: Fortes García Rafael Chieza , Melo de Oliveira Rafael , Martínez Eduardo Camilo , Borba Neves Eduardo
Published: March 2020

B

Objective: analyze the agreement of the V̇O2max values estimated by American College of Sports Medicine‎ and Foster equations with direct measure gas analyze in young Brazilian males. The maximal oxygen uptake, as a health indicator and mortality predictor, can be assessed in different ways. The gold standard comprises the direct measurement of exhaled gases, which entails high cost. A more conveniently form can be estimation equations. Materials and methods: this study assessed VO2max of 41 young Brazilian males (21.4 ±2.2 years) by cardiopulmonary exercise test in a treadmill ergometer with a ramp protocol. Bland and Altman analysis was performed to verify the agreement between V̇O2max measured and estimated values by ACSM and Foster equations. Results: the measured VO2max was 52.3 ± 4.9 ml.kg-1.min-1. The difference between the measured V̇O2max and the estimated V̇O2max by the ACSM equation (9.40±3.67) was approximately 7.5 times greater than the difference between the measured V̇O2max and estimated V̇O2max by Foster's equation (1.25±3.46). Bland Altman graphics shows that only ACSM equation had mean differences that were significantly different from the measured value. Conclusions: the ACSM equation showed not appropriate for during treadmill stress testing young adults in a ramp protocol and Foster equation seems to be a more accurate estimator of V̇O2max for this population, besides showed a bias along the aerobic capacity, trending to overestimates and underestimates V̇O2max of least and most fit people, respectively.
La salud desde la perspectiva de la resiliencia
Authors: Páez Cala Martha Lúz
Published: March 2020

Artículo de revisión que enfatiza la relevancia de articular la resiliencia en el quehacer en salud, bien sea enfocado en personas, grupos sociales o en instituciones, como énfasis para potenciar la salud, el bienestar y la calidad de vida. Para el logro de este propósito se requiere un trabajo integral e interdisciplinario que propenda por identificar y potenciar los recursos y fortalezas, la autonomía y autorresponsabilidad, a diferencia del énfasis tradicional en salud, centrado en la disfuncionalidad y en la patología. Se trata de una mirada positiva y optimista del desarrollo humano, en el que intervienen aspectos emocionales, cognitivos, interaccionales y sociales. Perspectiva que cuenta con el apoyo de la OMS y la OPS. La resiliencia fortalece una posición activa y protagónica de todos los agentes para la resolución de las situaciones que inciden en el bienestar y desarrollo de los individuos y colectividades. No es una cualidad estática sino dinámica, tampoco es innata puesto que puede incentivarse y fortalecerse, con el propósito de aportar a un afrontamiento de la existencia desde una visión activa, optimista y entusiasta, que genere empoderamiento y capacidad de agencia. Como conclusión se establece su complejidad y condición multifactorial, que implica condiciones a nivel personal, familiar y social. El concepto de resiliencia lleva a asumir una mirada compleja, ecosistémica, integral y contextual del fenómeno de lo humano, al igual que destaca el papel activo y protagónico de la persona en su proceso de desarrollo.
Definición, importancia y análisis de la empresa familiar
Authors: Rueda Galvis Javier Francisco , MÓNICA ANDREA RUEDA GALVIS Marueda
Published: March 2020

Con base en la importancia que representa la empresa familiar en el mundo, resulta oportuno desde el ámbito académico analizar sus características más representativas, a fin de estructurar estrategias que permitan mejorar su competitividad y sostenibilidad en el largo plazo. En este sentido, el presente documento expone un panorama general de este tipo de organizaciones, a fin de generar información estratégica que permita estructurar modelos de gestión y estructuras de gobierno corporativo para aprovechar sus ventajas competitivas a la vez que se garantiza su permanencia en el tiempo.
Malestar Psicológico en v´íctimas de violencia sexual, intrafamiliar y del conflicto armado
Authors: Cudris Torres Lorena , Guzmán Maciel Clara Gabriela , Gonzalez Mendoza Almeida Liliana , Silvera Torres Liliana , Bolaño Acosta Lilian
Published: March 2020

El manuscrito tiene por objetivo realizar una revisión sistemática del malestar psicológico que generan la violencia sexual, doméstica y del conflicto armado en Colombia. Se consultaron 27 fuentes entre artículos de revistas indexadas en Scopus y Wos, libros, informes del Instituto Nacional de Medicina Legal y Ciencias Forenses, Encuesta Nacional de Salud Mental, Programa de las Naciones Unidas para el Desarrollo –PNUD- y Universidad de los Andes, de los últimos 15 años, ubicados en las bases de datos y motores de búsqueda en ResearchGate, SciELO, EBSCO, ScienceDirect, PubMed, ProQuest, Google Scholar. Como palabras claves se utilizaron: violencia sexual, violencia intrafamiliar, conflictos bélicos, conflicto armado, malestar psicológico. Los resultados indican que las afectaciones psicológicas frecuentes, en personas que han padecido los tipos de violencia mencionadas, presentan por periodos de tiempo prolongado trastorno de estrés postraumático (TEPT), trastornos del estado del ánimo, específicamente depresión, ansiedad y trastornos de alimentación, trastorno psicótico agudo y consumo de sustancias psicoactivas.
MODEL REGULASI PADA PROSES BIODEGRADASI POLYETHYLENE TEREPHTHALATE (PET)
Authors: Talib Taufan
Published: March 2020

Tim International Genetically Engineered Machine (IGEM) Indonesia merancang sebuah sistem biodegradasi limbah Polyethylene Terephthalate (PET) menggunakan LC-Cutinase yang diproduksi oleh bakteri Escherchia Coli (E-Coli) dalam sistem whole cell biocatalys. Paper ini menghasilkan model matematika kontinu menggunakan Persamaan Diferensial Biasa (PDB) dan Fungsi Hill dari modul regulasi. Kemudian model tersebut diuji dengan melakukan analisis titik tetap dan nilai eigen. Hasil menunjukan model sudah dapat merepresentasikan fenomena biologi yang terjadi pada modul regulasi
PREDIKSI PENGGUNAAN BANDWIDTH MENGGUNAKAN ELMAN RECURRENT NEURAL NETWORK
Authors: Radjabaycolle Jefri , Pulungan Reza
Published: March 2020

Jaringan Syaraf Tiruan (JST) sering dipakai dalam menyelesaikan permasalahan tertentu seperti prediksi, klasifikasi, dan pengolahan data. Berdasarkan hal tersebut, dalam penelitian ini mencoba menerapkan JST untuk menangani permasalahan dalam prediksi penggunaan bandwidth. Sistem yang dikembangkan dapat digunakan untuk memprediksi pengunaan bandwidth dengan menerapkan Elman Recurrent Neural Network (ERNN). Struktur Elman dipilih karena dapat membuat iterasi jauh lebih cepat sehingga memudahkan proses konvergensi.. Vektor input yang digunakan menggunakan windows size. Hasil penelitian dengan menggunakan target error sebesar 0.001 menunjukkan nilai MSE terkecil yaitu pada windows size 11 dengan nilai 0.002833. Kemudian dengan menggunakan 13 neuron pada hidden layer diperoleh nilai error paling optimal (minimum error) sebesar 0.003725.
ANALISIS FAKTOR
Authors: Rumlawang Francis Y. , Toamain Adela S.
Published: March 2020

Analisis faktor adalah suatu analisis yang digunakan untuk meringkas informasi atau data jika dalam suatu penelitian terdapat berbagai variabel. Kebanyakan dari variabel-variabel dari data penelitian tersebut saling berkorelasi dan harus diperkecil jumlahnya sehingga dapat diperoleh data yang konseptual dan mudah dikelola. Proses analisis faktor dilakukan untuk mengetahui faktor-faktor apa saja yang mempengaruhi pelayanan pada FMIPA Unpatti. Berdasarkan matriks korelasi, diperoleh 5 variabel yang mempunyai nilai eigen di atas 1, artinya beberapa variabel tereduksi dan menghasilkan variabel baru yang disebut faktor. Faktor baru yang terbentuk merupakan kumpulan dari variabel-variabel dengan nilai loading yang tinggi yaitu di atas 0,3. Di antara 15 variabel awal setelah diproses, diperoleh 5 faktor baru. Kelima faktor baru tersebut meliputi kenyamanan, biaya perkuliahan, penerimaan beasiswa, biaya tambahan serta fasilitas pada FMIPA
APLIKASI FUZZY PADA PERMASALAHAN PROGRAM TAK-LINIER
Authors: Wattimena Abraham Z.
Published: March 2020

One of the most purpose of non linear programing is to determine the optimal solution of its objective function. If the objective function of a certain non linear programing only possess a uniqe value function, it is easy to calculate its optimal solution. However, if the objective function of non linier programing possess multi functions, so there are two possibilities to determine their optimal solutions. Theses depend on whether there are conflic among them or not. In order to make them more easier, the fuzzy parameter could be applied to calculate the optimal solution.
PENERAPAN ANALISIS KORELASI PARSIAL UNTUK MENENTUKAN HUBUNGAN PELAKSANAAN FUNGSI MANAJEMEN KEPEGAWAIAN DENGAN EFEKTIVITAS KERJA PEGAWAI
Authors: Telussa Ade M. , Persulessy Elvinus R. , Leleury Zeth A.
Published: March 2020

Korelasi parsial digunakan untuk mempelajari hubungan murni antara sebuah 1ariable bebas ( ) dengan 1ariable terikat ( ) dengan mengendalikan atau mengontrol 1ariable-variabel bebas yang lain yaitu 1ariable X2 dan X3 yang diduga mempengaruhi hubungan antara 1ariable X1 dengan Y. Penelitian ini bertujuan untuk mengetahui bagaimana hubungan Pelaksanaan Fungsi Manajemen Kepegawaian dengan Efektivitas Kerja Pegawai. Sampel yang digunakan dalam penelitian ini berjumlah 50 responden. Metode 1ariable data yang digunakan lebih dulu yaitu uji validitas dan reliabilitas serta uji asumsi dalam hal ini yaitu uji normalitas dengan mengunakan uji kolmogorov-smirnov. Hubungan dari antara ketiga 1ariable bebas terhadap 1ariable terikat yang terjadi hubungan yang kuat adalah 1ariable pelatihan, dimana 1ariable penempatan kerja pegawai sesuai dengan keahlian dan kemampuannya dan 1ariable promosi dikontrol yaitu dengan . berdasarkan uji signifikansi, terdapat hubungan yang signifikan antara pelatihan dan efektivitas kerja pegawai karena , jika penempatan pegawai sesuai dengan keahlian dan kemampuannya dan juga promosi dibuat tetap (dikontrol).
PELABELAN SUPER MUKA ANTI-AJAIB PADA KELAS GRAF PLANAR
Authors: Halim Christian , Rumlawang Francis Y. , Patty Henry W.
Published: March 2020

Penelitian ini berfokus pada pelabelan super anti-ajaib dari graf planar tipe Akan ditunjukkan bahwa suatu kelas dari graf planar yang didefinisikan menggunakan graf lengkap dan suatu kelas dari graf planar yang didefinisikan menggunakan graf bipartit lengkap adalah dan super anti-ajaib dengan keadaan tertentu.
KLASIFIKASI NEAR-RING
Authors: Persulessy Elvinus R.
Published: March 2020

Sebagimana pada grup dan ring, struktur-struktur baru yang berkaitan dengan keduanya dapat dibentuk dengan menambahkan ciri-ciri baru pada kedua struktur tersebut. Ciri-ciri baru inilah yang berperan dalam membentuk klasifikasi grup dan ring. Near-ring sebagai salah satu struktur yang terbentuk dari ring mengalami hal yang sama. Penelitian ini bertujuan untuk memperkenalkan jenis-jenis near-ring yang berperan dalam mengklasifikasi near-ring dan karakteristik yang timbul sebagai akibatnya, terutama yang berkaitan dengan ketunggalan elemen identitas dan invers.
PENDEKATAN MODEL GEOGRAPHICALLY WEIGHTED REGRESSION UNTUK MENENTUKAN FAKTOR-FAKTOR YANG MEMPENGARUHI JUMLAH RUMAH TANGGA MISKIN DI PULAU BURU
Authors: Aulele Salmon N.
Published: March 2020

Kemiskinan merupakan persoalan yang kompleks, karena tidak hanya berkaitan dengan masalah rendahnya tingkat pendapatan dan konsumsi, tetapi juga berkaitan dengan rendahnya tingkat pendidikan, kesehatan serta ketidakberdayaannya untuk berpartisipasi dalam pembangunan. Tujuan penelitian ini adalah menentukan faktor-faktor yang mempengaruhi jumlah rumah tangga miskin dengan memperhatikan faktor geografis di Pulau Buru menggunakan model Geographically Weighted Regression (GWR), sehingga diperoleh model yang dapat digunakan untuk memperkirakan jumlah rumah tangga miskin 13 Kecamatan di Pulau Buru. Hasil penelitian menunjukan bahwa variabel yang signifikan mempengaruhi jumlah rumah tangga miskin di tiap kecamatan di Pulau Buru yaitu banyaknya rumah tangga yang tidak punya fasilitas tempat buang air besar atau bersifat umum (X1), banyaknya rumah tangga yang sumber penerangan utama bukan listrik (X2), banyaknya rumah tangga yang sumber air minumnya dari sumur/mata air tak terlindung/sungai (X4), banyaknya rumah tangga yang pengeluaran untuk makanannya lebih besar 80% (X5) serta banyaknya rumah tangga yang pendidikan tertinggi kepala rumah tangganya SD kebawah (X7).
PERAMALAN JUMLAH PENGUNJUNG PERPUSTAKAAN UNIVERSITAS PATTIMURA AMBON MENGGUNAKAN METODE DEKOMPOSISI
Authors: Yuni Sitri , Talakua Mozart W. , Lesnussa Yopi A.
Published: March 2020

Perpustakaan merupakan pusat informasi yang harus dikelola dengan baik agar dapat memberikan manfaat semaksimal mungkin. Penelitian ini bertujuan untuk mengetahui fluktuasi dan meramalkan banyaknya pengunjung Perpustakaan Universitas Pattimura (UNPATTI) Ambon menggunakan metode Dekomposisi. Data yang digunakan adalah data sekunder jumlah pengunjung perpustakaan UNPATTI sejak tahun 2011– 2014 yang diperoleh dari perpustakaan UNPATTI. Prosedur penelitian dimulai dengan menganalisis komponen-komponen dekomposisi yaitu komponen trend (𝑇), musiman (𝑆), siklis (𝐶) dan komponen acak (𝐼) kemudian mengalikan nilai dari komponen-komponen tersebut. Hasil prediksi menunjukkan bahwa jumlah pengunjung pada tahun 2015 bulan Januari sebesar 1337 pengunjung, Februari 2932 pengunjung, Maret 3640 pengunjung, April 3791 pengunjung, Mei 4333 pengunjung, Juni 2571 pengunjung, Juli 806 pengunjung, Agustus 920 pengunjung, September 968 pengunjung, Oktober 4187 pengunung, November 4495 pengunjung dan Desember 2960 pengunjung. Dapat dilihat bahwa jumlah pengunjung meningkat pada bulan Mei dan November.
APLIKASI METODE FUZZY C-MEANS UNTUK PENGKLASTERAN KELAYAKAN RUMAH DI DESA WAYAME, AMBON
Authors: Sormin R. P. A. , Rumlawang F. Y. , Sinay L. J.
Published: March 2020

Pengklasteran adalah proses pengelompokan data ke dalam klaster berdasarkan parameter tertentu sehingga obyek-obyek dalam sebuah klaster memiliki tingkat kemiripan yang tinggi satu sama lain dan sangat tidak mirip dengan obyek yang lain pada klaster yang berbeda. Algoritma Fuzzy C-Means termasuk salah satu teknik pengklasteran data yang mana keberadaan pada setiap titik data dalam suatu klaster ditentukan oleh derajat keanggotaan. Pada penelitian ini Algoritma Fuzzy C-Means digunakan untuk menentukan kelayakan rumah. Hasil yang diperoleh menunjukkan bahwa masih banyak rumah yang tidak layak di Desa wayame yang harus lebih diperhatikan.
ANALISIS KEBIJAKAN PENGENDALIAN INFLASI DKI JAKARTA
Authors: Yurianto Yurianto
Published: March 2020

Jakarta's role in the national economy is very central. Contributions economy Jakarta nationwide reach 16 to 17 percent of total national GDP. Indicators of inflation is very central.Inflation is low and stable would be a stimulator of economic growth. This study aims to: a) discuss the development of the inflation rate in Jakarta, b) discuss and analyze the policy of inflation control in Jakarta and c) comparing the calculation of the inflation rate to the inflation rate in 2017-2022 RPJMD. The study used a qualitative descriptive approach. In conclusion Regional Inflation Control Team (TPID) Jakarta to be very central in controlling inflation. BUMD, the food cluster was instrumental and constructive in terms of the provision of some major food commodities. The rate of inflation and economic growth RPJMD and Simultaneous Equation Model shows that there are differences in nominal figures. But in the nominal rate projections for both relatively stable and the same. Policy strategy of the four K (4 K), namely affordability, availability of supplies, smoothness distribution and communications has given excellent results and is conducive to the economy of Jakarta. The Jakarta Provincial Government cooperation with the regions and between enterprises working with other regions Jakarta quite effective.bazaar and market operations are to periodically shown to be effective in controlling inflation. So it is necessary to continue.
Moderasi Islam (Wasathiyyah) di Tengah Pluralisme Agama Indonesia
Authors: Busyro Busyro , Ananda Aditiya Hari , Adlan Tarihoran Sanur
Published: March 2020

Negara Indonesia merupakan Negara yang majemuk dari sisi agama, budaya, dan suku. Hal ini dapat menjadi potensi kemajuan bangsa dan sebaliknya juga dapat mengancam eksistensi Negara. Persoalan yang sering menjadi sorotan adalah pluralisme agama, karena agama merupakan sesuatu yang lebih sensitive dibandingkan dengan perbedaan lainnya. Islam di Indonesia merupakan agama mayoritas yang harus mengambil peran dalam menstabilkan kehidupan bernegara. Pandangan yang moderat tentang keragaman agama di Indonesia harus selalu dipupuk untuk menjadikan Indonesia menjadi Negara yang damai dalam kemajemukan. Oleh karena itu diperlukan upaya bagaimana menjadikan moderasi Islam sebagai cara untuk mengakomodir pluralisme agama di Indonesia. Dari pembahasan dapat disimpulkan bahwa Islam tidak menganggap semua agama itu  sama tapi memperlakukan semua agama itu sama dengan mengedepankan  tasamuh (toleransi), kemudian syura (musyawarah) antar agama, dan punya sikap musawah (tidak diskriminatif).
SEXUAL HAZING AND ABUSE PHENOMENA IN TONI MORRISON THE BLUEST EYE
Authors: Swasti Ratu Ken Kirana , Supsiadji Mateus Rudi
Published: March 2020

This essay focuses the discussion on sexual hazing and sexual abuse phenomena which had happened to several roles in Toni Morrisonâ€™s The Bluest Eye. The method used was a descriptive confirmatory method meaning the method approached and analyzed the study based on the confirmation of the theory and data from its own novel. In addition, this essay applied some points about socialist feminism as the additional reference of discussion. Socialist feminism itself is a branch of feminism that focuses upon both the public and private spheres of womenâ€™s life and argues that liberation can only be achieved by working to end both the economic and cultural resources of womenâ€™s oppression. The result showed Cholly had an sexual experience with humiliation, Frieda who was experienced abuse from Mr. Henry as well as Pecola, the lead role of this novel who had sexual hazing through rape.
REPRESENTATION OF NYI RORO KIDUL IN MYTH, LEGEND, AND POPULAR CULTURE
Authors: Andayani Ambar , Jupriono Jupriono
Published: March 2020

Nyi Roro Kidul, Nyai Loro Kidul, or Nyai Ratu Kidul is a character of folk legend which has existedÂ  all along south coast of Java land: from East Java, to Middle Java and Jogjakarta, then to West Java and Banten. People along the south coast of Java island believe to myth of this legendary character as a beautiful and supernatural woman who has authority of devil realm in Indonesian Ocean (Indian Ocen) or Segoro Kidul (South Sea). The popularity of Nyi Roro Kidul has also become motivation for national film-making and TV media to produce many films and drama about this character. Although there are many similarities about the revelation, among regions, legend and mass culture (film, TV); the representations of Nyi Roro Kidul show differences in theme emphasis.Â  In East Javanese people, Nyi Roro Kidul is emphasized on the intention of people seeking wealth pesugihan (with the helping from devils) by sacrificing human soul for antidote. In Middle Javanese people, Kanjeng Ratu Kidul is representated as the take turn-wife of Sultans from Mataram, Sultan Panembahan Senopati to Sultans of Jogjakarta in the present time. The west Javanese people represents this figure as the princess of Pakuan Pajajaran Kingdom who is betrayed and abused, and throw away herself to jump into South Sea, then she incarnates as a beautiful and undefeated supernatural queen. On film and television, Nyi Roro Kidul is presented as a beautiful, sexy, cruel and sexual adventurer woman.
A priori estimates of the positive solution of the two-point boundary value problem for one second-order nonlinear differential equation
Authors: Abduragimov Edelkhan
Published: March 2020

A priori estimates of the positive solution of the two-point boundary value problem are obtained $y^{\prime\prime}=-f(x,y)$, $0<x<1$, $y(0)=y(1)=0$ assuming that $f(x,y)$ is continuous at $x \in [0,1]$, $y \in R$ and satisfies the condition $a_0 x^{\gamma}y^p \leq f(x,y) \leq a_1 y^p$, where $a_0>0$, $a_1>0$, $p>1$, $\gamma \geq 0$ -- constants.
Some aspects of familiarization with binomial coefficients
Authors: Magomedov Abdulkarim , Lavrenchenko S.A.
Published: March 2020

New laconic proofs of two classical statements of combinatorics are proposed, computational aspects of binomial coefficients are considered, and examples of their application to problems of elementary mathematics are given.
Simulação da pegada hídrica da soja no Mato Grosso baseada em projeções de mudanças climáticas
Authors: Dias Giulia Vitória Simioni , Silva Evandro Henrique Figueiredo Moura da , Antolin Luis Alberto Silva , Vieira Junior Nilson Aparecido , Marin Fábio Ricardo
Published: March 2020

O consumo de água de doce pela agricultura equivale a 70% da água doce no mundo (FAO, 2012), esse fato aliado a evidência das mudanças climáticas e ao crescimento populacional para as próximas décadas, torna-se importante a quantificação do uso de água na irrigação para conciliar o aumento da produção com a mínima pressão sobre os mananciais. Para essa mensuração, é utilizado a metodologia da pegada hídrica (Hoekstra et al., 2011), que é composta pelo componente azul, verde e cinza. Este trabalho avaliou o uso futuro da água na irrigação de soja no Mato Grosso, quantificando a pegada hídrica azul (PHazul) baseado em projeções de mudanças climáticas usando o modelo agrícola DSSAT/CROPGRO-Soybean. As simulações não apresentaram grande variação da PHazul em relação a atual, a menor variação foi da zona edafoclimática homogênea (ZH) de Nova Mutum, onde variou 27 m³ Mg-1, entre o cenário 1 e o 6 e a maior variação foi de Primavera do Leste, com variação de 81,2 m³ Mg-1 entre o cenário atual e o 6. Esse resultado pode ser explicado pela manutenção da produtividade da soja nas ZH estudadas, onde a maior variação registrada foi de -1,6% e pela diminuição da evapotranspiração em 6,5%.
Signifikansi Taurat Tuhan Dalam Mazmur 119: 97-106
Authors: Pasaribu Ferdinan
Published: March 2020

as King David. Because the word of God always gives directions for King David's life. The love of the Law of God gave birth to a commitment for him to meditate on all day long. The significance of God's word is: First, the Giver of the word is Almighty God. Second, God's Word contains all the rules of life for all humans. Third, God's Word provides an intimacy between people and God. Fourth, the word of God can shape the character of life. That significance makes King David love the word of God. But, in fact, today there are many Christians who do not understand the significance of God's word so that Christians do not have the desire to love and meditate on the word of God. This condition is found in the Protestant Gospel Archipelago Church of Karang Anyar Lampung where the congregation does not yet understand the significance of God's word so that the congregation does not have a love of God's word. The church does not yet understand that the giver of the word is Almighty God. The church does not understand that the word of God reveals all the rules of life, intimacy and can shape character. Therefore, the church must understand the significance of God's word. If the church understands the significance of God's word, the church will love His words and keep all His laws.
In a Lonely Place: Investigating Regional Differences in Loneliness
Authors: Buecker Susanne , Ebert Tobias , Götz Friedrich Martin , Entringer Theresa M. , Luhmann Maike
Published: March 2020

Loneliness has traditionally been studied on the individual level. This study is one of the first to systematically describe and explain differences in loneliness on a fine-grained regional level. Using data from the nationally representative German Socioeconomic Panel Study (N = 17,602), we mapped the regional distribution of loneliness across Germany and examined whether regional differences in loneliness can be explained by both individual and regionalcharacteristics. Perceived neighborhood relation, perceived distance to public parks and sport/leisure facilities as well as objective regional remoteness and population change were positively related to loneliness. Individual-level characteristics, however, appeared to be more important in explaining variance in loneliness. In sum, loneliness varies across geographical regions, and these differences can partly be linked to characteristics of these regions. Our results may aid governments and public health care services to identify geographical areas most at risk for loneliness and resulting physical and mental health issues.
Impact of Paramparagath Krishi Vikas Yojana (an organic agriculture scheme of government of India), National Institute of Agricultural Extension Management (MANAGE), Rajendranagar, Hyderabad – 500030, Telangana State, India. 81 pp.
Authors: Reddy A Amarender
Published: March 2020

This report examines the impact of the government of India’s organic agriculture scheme – Paramparagat Krishi Vikas Yojana (PKVY). Since the2015-16, the Government of India is promoting organic agriculture under PKVY scheme through the promotion of Participatory Guarantee Scheme (PGS) certified organic clusters. Under PKVY, clusters will be supported by notified regional councils to provide PGS certification. Although the progress is uneven across states, it has the potential for growth in rain fed, remote and hilly areas. There are some implementation problems like lack of local initiatives, lags in fund flow. Due to the practice of organic agriculture, the costs were lower by 10-12 per cent when compared to conventional agriculture, but yields were also lower by 4-5 per cent, the net result is higher net returns by about 10-15 per cent depending on the crop and area. More focus needs to be given for the vertical expansion of the area in identified zones like hilly areas.
PENDIDIKAN LITERASI FINANSIAL MELALUI PEMBELAJARAN FIQH MU’ĀMALĀT BERBASIS KITAB KUNING
Authors: Setiawan Adib Rifqi
Published: March 2020

This research goals to gain the design for a learning program to guide students in pondok pesantren on achieving financial literacy throughout fiqh mu’āmalāt learning that is based on kitab kuning. We used R&D approach 4D model that reduced into three stages: define, design, and develop. It was gained a syllabus that completed by lesson plan, student worksheets, nor assessment instrument as well, that validated by experts and practitioners and reliability counted based on test.
High-rise social failures
Authors: Tamburo Elisa
Published: March 2020

This article focuses on the “social failure” of the relocation of the residents from informal historical settlements—military dependents’ villages (juancun)—to high-rise blocks in Taiwan. How does the relocation impact the community and restructure social relationships? I argue social failure is the product of new regulative regimes deriving from the new governance of the high-rise, rather than of the built form of the complexes in itself. New home technologies such as intercoms, elevators, and electronic keys contribute to arguments over safety and convenience, while new regulations, implemented by new forms of authority, including condominium meetings and building administrators, foster the disappearance of household informal economies. Finally, the high-rise dictates new aesthetic norms, which prevent established practices and routines, while promoting what I call aesthetic of assimilation.
Targeting glioma-initiating cells via the tyrosine metabolic pathway
Authors: Yamashita Daisuke , Bernstock Joshua D. , Elsayed Galal , Sadahiro Hirokazu , Mohyeldin Ahmed , Chagoya Gustavo , Ilyas Adeel , Mooney James , Estevez-Ordonez Dagoberto , Yamaguchi Shinobu , Flanary Victoria L. , Hackney James R. , Bhat Krishna P. , Kornblum Harley I. , Zamboni Nicola , Kim Sung-Hak , Chiocca E. Antonio , Nakano Ichiro
Published: March 2020

OBJECTIVE

Despite an aggressive multimodal therapeutic regimen, glioblastoma (GBM) continues to portend a grave prognosis, which is driven in part by tumor heterogeneity at both the molecular and cellular levels. Accordingly, herein the authors sought to identify metabolic differences between GBM tumor core cells and edge cells and, in so doing, elucidate novel actionable therapeutic targets centered on tumor metabolism.

METHODS

Comprehensive metabolic analyses were performed on 20 high-grade glioma (HGG) tissues and 30 glioma-initiating cell (GIC) sphere culture models. The results of the metabolic analyses were combined with the Ivy GBM data set. Differences in tumor metabolism between GBM tumor tissue derived from within the contrast-enhancing region (i.e., tumor core) and that from the peritumoral brain lesions (i.e., tumor edge) were sought and explored. Such changes were ultimately confirmed at the protein level via immunohistochemistry.

RESULTS

Metabolic heterogeneity in both HGG tumor tissues and GBM sphere culture models was identified, and analyses suggested that tyrosine metabolism may serve as a possible therapeutic target in GBM, particularly in the tumor core. Furthermore, activation of the enzyme tyrosine aminotransferase (TAT) within the tyrosine metabolic pathway influenced the noted therapeutic resistance of the GBM core.

CONCLUSIONS

Selective inhibition of the tyrosine metabolism pathway may prove highly beneficial as an adjuvant to multimodal GBM therapies.
Comparative preoperative characteristics and postoperative outcomes at a private versus a safety-net hospital following endoscopic endonasal transsphenoidal resection of pituitary adenomas
Authors: Cyprich Janelle , Pangal Dhiraj J. , Rutkowski Martin , Donoho Daniel A. , Shiroishi Mark , Jason Liu Chia-Shang , Carmichael John D. , Zada Gabriel
Published: March 2020

OBJECTIVE

Sociodemographic disparities in health outcomes are well documented, but the effects of such disparities on preoperative presentation of pituitary adenomas (PA) and surgical outcomes following resection are not completely understood. In this study the authors sought to compare the preoperative clinical characteristics and postoperative outcomes in patients undergoing PA resection at a private hospital (PH) versus a safety-net hospital (SNH).

METHODS

The authors conducted a retrospective review over a 36-month period of patients with PAs who underwent endoscopic endonasal transsphenoidal surgery performed by the same attending neurosurgeon at either a PH or an SNH at a single academic medical institution.

RESULTS

A total of 92 PH patients and 69 SNH patients were included. SNH patients were more likely to be uninsured or have Medicaid (88.4% vs 10.9%, p < 0.0001). A larger percentage of SNH patients were Hispanic (98.7% vs 32.6% p < 0.0001), while PH patients were more likely to be non-Hispanic white (39.1% vs 4.3%, p < 0.0001). SNH patients had a larger mean PA diameter (26.2 vs 22.4 mm, p = 0.0347) and a higher rate of bilateral cavernous sinus invasion (13% vs 4.3%, p = 0.0451). SNH patients were more likely to present with headache (68.1% vs 45.7%, p = 0.0048), vision loss (63.8% vs 35.9%, p < 0.0005), panhypopituitarism (18.8% vs 4.3%, p = 0.0031), and pituitary apoplexy (18.8% vs 7.6%, p = 0.0334). Compared to PH patients, SNH patients were as likely to undergo gross-total resection (73.9% vs 76.1%, p = 0.7499) and had similar rates of postoperative improvement in headache (80% vs 89%, p = 0.14) and vision (82% vs 84%, p = 0.74), but had higher rates of postoperative panhypopituitarism (23% vs 10%, p = 0.04) driven by preoperative endocrinopathies. Although there were no differences in tumor recurrence or progression, loss to follow-up was seen in 7.6% of PH versus 18.6% (p = 0.04) of SNH patients.

CONCLUSIONS

Patients presenting to the SNH were more often uninsured or on Medicaid and presented with larger, more advanced pituitary tumors. SNH patients were more likely to present with headaches, vision loss, and apoplexy, likely translating to greater improvements in headache and vision observed after surgery. These findings highlight the association between medically underserved populations and more advanced disease states at presentation, and underscore the likely role of academic tertiary multidisciplinary care teams and endoscopic PA resection in somewhat mitigating sociodemographic factors known to portend poorer outcomes, though longer-term follow-up is needed to confirm these findings.
Surgical outcomes of the endonasal endoscopic approach within a standardized management protocol for repair of spontaneous cerebrospinal fluid rhinorrhea
Authors: Kreatsoulas Daniel C. , Shah Varun S. , Otto Bradley A. , Carrau Ricardo L. , Prevedello Daniel M. , Hardesty Douglas A.
Published: March 2020

OBJECTIVE

Spontaneous CSF leaks are rare, their diagnosis is often delayed, and they can precipitate meningitis. Craniotomy is the historical “gold standard” repair for these leaks. An endonasal endoscopic approach (EEA) offers potentially less invasiveness and lower surgical morbidity than a traditional craniotomy but must yield the same surgical success. A paucity of data exists studying EEA as the primary management for spontaneous CSF leaks.

METHODS

The authors retrospectively reviewed patients undergoing spontaneous CSF rhinorrhea repair at their institution from July 2010 to August 2018. Standardized management includes EEA as first-line treatment, and lumbar puncture (LP) performed 24–48 hours postoperatively. If opening pressure on LP is elevated, CSF diversion or acetazolamide therapy is used as needed. Perioperative lumbar drains are not used.

RESULTS

Of 46 patients identified, the most common CSF rhinorrhea etiology was encephalocele (28/46, 60.9%), and the most common location was cribriform/ethmoid (26/46, 56.5%). Forty-three patients underwent EEA alone, and 3 underwent a simultaneous EEA/craniotomy. The most common repair strategy was nasoseptal or other pedicled flaps (18/46, 39.1%). Postoperatively, 15 patients (32.6%) received CSF diversion due to elevated ICP, with BMI > 40 kg/m2 being a significant risk factor (odds ratio 4.35, p = 0.033) for postrepair shunt placement. Twelve patients received acetazolamide therapy for treatment of mildly elevated pressures. The average opening pressure of the shunted group was 36 cm H2O and the average for the acetazolamide-only group was 26 cm H2O. Two patients underwent CSF leak repair revision, one because of progressive fungal sinusitis and the other because of recurrent CSF leak. The mean follow-up duration was 15 months.

CONCLUSIONS

The paradigm of EEA repair of spontaneous CSF rhinorrhea with postoperative LP to identify undiagnosed idiopathic intracranial hypertension appears to be safe and effective. In the authors’ cohort, morbid obesity was statistically associated with the need for postoperative CSF diversion. This has implications for future surgical treatment as obesity levels continue to rise worldwide.
Predictors of second-sided deep brain stimulation for Parkinson’s disease
Authors: Golubovsky Joshua L. , Li Hong , Momin Arbaz , Shao Jianning , Lee Maxwell Y. , Frizon Leonardo A. , Hogue Olivia , Walter Benjamin , Machado André G. , Nagel Sean J.
Published: March 2020

OBJECTIVE

Parkinson’s disease (PD) is a progressive neurological movement disorder that is commonly treated with deep brain stimulation (DBS) surgery in advanced stages. The purpose of this study was to investigate factors that affect time to placement of a second-sided DBS lead for PD when a unilateral lead is initially placed for asymmetrical presentation. The decision whether to initially perform unilateral or bilateral DBS is largely based on physician and/or patient preference.

METHODS

This study was a retrospective cohort analysis of patients with PD undergoing initial unilateral DBS for asymmetrical disease between January 1999 and December 2017 at the authors’ institution. Patients treated with DBS for essential tremor or other conditions were excluded. Variables collected included demographics at surgery, time since diagnosis, Unified Parkinson’s Disease Rating Scale motor scores (UPDRS-III), patient-reported quality-of-life outcomes, side of operation, DBS target, intraoperative complications, and date of follow-up. Paired t-tests were used to assess mean changes in UPDRS-III. Cox proportional hazards analysis and the Kaplan-Meier method were used to determine factors associated with time to second lead insertion over 5 years.

RESULTS

The final cohort included 105 patients who underwent initial unilateral DBS for asymmetrical PD; 59% of patients had a second-sided lead placed within 5 years with a median time of 34 months. Factors found to be significantly associated with early second-sided DBS included patient age 65 years or younger, globus pallidus internus (GPi) target, and greater off-medication reduction in UPDRS-III score following initial surgery. Older age was also found to be associated with a smaller preoperative UPDRS-III levodopa responsiveness score and with a smaller preoperative to postoperative medication-off UPDRS-III change.

CONCLUSIONS

Younger patients, those undergoing GPi-targeted unilateral DBS, and patients who responded better to the initial DBS were more likely to undergo early second-sided lead placement. Therefore, these patients, and patients who are more responsive to medication preoperatively (as a proxy for DBS responsiveness), may benefit from consideration of initial bilateral DBS.
Impact of endplate-implant area mismatch on rates and grades of subsidence following stand-alone lateral lumbar interbody fusion: an analysis of 623 levels
Authors: Agarwal Nitin , White Michael D. , Zhang Xiaoran , Alan Nima , Ozpinar Alp , Salvetti David J. , Tempel Zachary J. , Okonkwo David O. , Kanter Adam S. , Hamilton D. Kojo
Published: March 2020

OBJECTIVE

Stand-alone lateral lumbar interbody fusion (LLIF) is a useful minimally invasive approach for select spinal disorders, but implant subsidence may occur in up to 30% of patients. Previous studies have suggested that wider implants reduce the subsidence rate. This study aimed to evaluate whether a mismatch of the endplate and implant area can predict the rate and grade of implant subsidence.

METHODS

The authors conducted a retrospective review of prospectively collected data on consecutive patients who underwent stand-alone LLIF between July 2008 and June 2015; 297 patients (623 surgical levels) met inclusion criteria. Imaging studies were examined to grade graft subsidence according to Marchi criteria. Thirty patients had radiographic evidence of implant subsidence. The endplates above and below the implant were measured.

RESULTS

A total of 30 patients with implant subsidence were identified. Of these patients, 6 had Marchi grade 0, 4 had grade I, 12 had grade II, and 8 had grade III implant subsidence. There was no statistically significant correlation between the endplate-implant area mismatch and subsidence grade or incidence. There was also no correlation between endplate-implant width and length mismatch and subsidence grade or incidence. However, there was a strong correlation between the usage of the 18-mm-wide implants and the development of higher-grade subsidence (p = 0.002) necessitating surgery. There was no significant association between the degree of mismatch or Marchi subsidence grade and the presence of postoperative radiculopathy. Of the 8 patients with 18-mm implants demonstrating radiographic subsidence, 5 (62.5%) required reoperation. Of the 22 patients with 22-mm implants demonstrating radiographic subsidence, 13 (59.1%) required reoperation.

CONCLUSIONS

There was no correlation between endplate-implant area, width, or length mismatch and Marchi subsidence grade for stand-alone LLIF. There was also no correlation between either endplate-implant mismatch or Marchi subsidence grade and postoperative radiculopathy. The data do suggest that the use of 18-mm-wide implants in stand-alone LLIF may increase the risk of developing high-grade subsidence necessitating reoperation compared to the use of 22-mm-wide implants.
Synergy of the Word and Music as the Basis of the Creative Method of Working by Z.P. Lodiy with Poetic Texts in Chamber Vocal Piece
Authors: Zheurova Violetta , Sharma Elena
Published: March 2020

The article is devoted to the synthesis of words and music in the performing arts of the chamber singer of the first half of the twentieth century, Zoya Petrovna Lodiy. Her skill was highly appreciated by the representatives of the artistic elite and caused enthusiastic responses from the general public. However, over time, not only the name of the singer was undeservedly forgotten, but the recordings of her performances became a real rarity and are not almost available for listening. Therefore, the only source for studying the work of the famous vocalist was the memoirs of contemporaries, the periodical press, the epistolary heritage, as well as various archival materials that make it possible to form a certain idea about Z. P. Lodiy’s mastery in artistic and expressive means of singing, due to the singer’s deep and multifaceted attitude to the word. An analysis of the artist’s creative heritage made it possible to identify the key principles of her creative method of working with poetic texts in chamber vocal piece. In this regard, the particular interest is the work by Z. P. Lodiy with verbal texts when editing the collection of Songs by F. Schubert to the words of Goethe in the translation of S. A. Adrianov, published in 1934 under her revision. The study showed that the unique experience by Zoe Lodiy deserves to be studied, serious scientific reflection and can provide significant assistance in training modern young performers.
Limited Stage Small Cell Bladder Cancer: Outcomes of a Contemporary Cohort
Authors: Grigg Claud M. , Boselli Danielle , Livasy Chad , Symanowski James , McHaffie Derek R. , Riggs Stephen , Clark Peter E. , Beano Hamza , Raghavan Derek , Burgess Earle F.
Published: March 2020

BACKGROUND:

Limited stage small cell bladder cancer is curable with multi-modality therapy using external beam radiotherapy or radical cystectomy. The optimal management strategy for this rare disease is still debated, yet few case series have described patients treated after 2010.

OBJECTIVE:

To analyze outcomes from a contemporary cohort of patients undergoing definitive treatment.

METHODS:

Patients diagnosed with small cell bladder cancer after January 1, 2010 were identified from an institutional database. Clinical histories were collected by chart review. Survival outcomes were analyzed in patients who received curative-intent therapy consisting of bladder radiotherapy or cystectomy.

RESULTS:

Thirty patients with limited stage disease that received definitive therapy were identified. Seventeen patients received primary radiotherapy, and thirteen underwent cystectomy. Median age was 70 years. Median follow up was 39.6 months (range 7.2–95.8). The median overall survival of patients undergoing radiotherapy or cystectomy were 36.8 and 30.6 months, respectively (hazard ratio 0.99, 95% confidence interval 0.35–2.85). The median metastasis free survival for patients receiving radiotherapy was not reached, and 18.9 months in the cystectomy group (hazard ratio 0.94, 95% confidence interval 0.34–2.61). The most common sites of relapse were lymph node ( n = 6) and bone ( n = 5). Brain metastases were less common ( n = 3).

CONCLUSIONS:

Patients receiving cystectomy or radiotherapy had similar outcomes in this contemporary series, but definitive comparisons are limited by the cohort size and high censoring rate (53%). Survival in our cohort is improved compared with older reports, though outcomes remain poor, reiterating the need for better therapeutic options.