bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental validation of antisurditant use of triazine-indole derivative on exposure of high intensity noise
Authors:   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Dvoryanchikov V. V. , Kuznetsov M. S. ,   Kirov Military Medical Academy, Saint Petersburg, 194044, Russia, Pastushenkov V. L. ,   LLC „Farm-Trisan”, Saint Petersburg, 191015, Russia, Glaznikov L. A. ,   Kirov Military Medical Academy, Saint Petersburg, 194044, Russia, Karev V. E. ,   Children’s Scientific and Clinical Center of Infectious Diseases, Saint Petersburg, 197022, Russia
Published: February 2023

In the study on the model of acoustic trauma in experimental animals (mice), the otoprotective effect of the triazine-indole derivative was shown due to the influence on the expression level of hypoxia-inducible factor (HIF) in the Corti organ and spiral ganglion cells. For therapeutic purposes, the drug was administered as a 1% solution at a dosage of 5, 7, 10 mg/kg 2 hours after acoustic exposure. For preventive purposes, the drug was administered at a dosage of 5, 7, 10 mg/kg for 3 days before acoustic exposure. The comparator drug was Cytoflavin. The control group received a saline solution. The immunohistochemical study was carried out using an anti-mouse polymerized immunohistochemical imaging system and mouse monoclonal antibodies to HIF1. In immunohistochemical preparations scanned using a digital scanner, the HIF1-positive area (%) in the cochlea and spiral ganglion cells was calculated using a morphometric program. The color was evaluated by the average cytochemical coefficient. It was found that the severity of HIF expression depended on the dose of the administered drug and coincided with electrophysiological changes in experimental animals. The antisurditant effect of the triazine-indole derivative is realized by influencing the level of HIF expression, which allows it to be regarded as a target molecule when using the drug.
Entendimento da perinatalidade a partir do modelo de seleção por consequências
Authors: Rocha Carolina Neves da , Linares Ila Marques Porto , Weiss Julia Vasconcellos Pacheco
Published: February 2023

Saúde mental perinatal é uma área que estuda o período em torno do nascimento de um bebê e seus impactos sobre as pessoas envolvidas neste processo, especialmente a mulher que está se tornando mãe. O presente trabalho teve como objetivo levantar variáveis funcionais e contextuais a partir das reflexões de mulheres, mães e analistas do comportamento, sobre suas experiências pessoais. Para isso, foram entrevistadas três mulheres, que, além de estarem envolvidas com ensino, pesquisa e/ou supervisão em Análise do Comportamento, tinham tido filhos entre 1 ano e 2 anos e 2 meses. A partir das reflexões geradas pelas entrevistas, foram levantados conceitos e processos comportamentais envolvidos na perinatalidade, organizados nas seguintes categorias: condições antecedentes; repertório/classes de respostas; consequentes; aspectos filogenéticos; contingências entrelaçadas e metacontingências e; colaterais emocionais. Os dados foram discutidos sob a luz do modelo de seleção pelas consequênciase articulados com a literatura levantada sobre perinatalidade. O estudo teve como principal contribuição levantar diversas variáveis que podem ser melhor investigadas em estudos posteriores, bem como serem consideradas na prática clínica em casos que envolvam a transição para a parentalidade.
Genetic diversity of Candidatus Liberibacter asiaticus strains from the Central Pacific citrus region in Mexico
Authors: Manzo-Sánchez Gilberto , Romero-Parra Fernando , Guzmán-González Salvador , Buenrostro-Nava Marco Tulio , Orozco-Santos Mario , Velázquez-Monreal José Joaquín , Manzanilla-Ramírez Miguel Ángel
Published: February 2023

Huanglongbing (HLB) is associated with Candidatus Liberibacter asiaticus (CLas). It is a destructive disease of citrus. The objective of this study was to determine the genetic diversity of 90 strains of CLas infecting eight citrus species trees from the Central Pacific in Mexico. Genetic diversity among CLas was estimated by fourteen variable numbers of tandem repeat (VNTRs) loci. Three loci were polymorphic, SSR00 and SSR077 amplified four alleles each, while the locus SSR-A amplified two alleles, and the other loci only one allele per locus, resulting in a total of 21 alleles. Dendrogram analysis showed two clusters. No clear genetic structure was found in relation to geographical origin or host. The cluster I was mostly constituted by the majority of CLas strains (82%), but the cluster II comprised twelve strains of CLas collected in Tecoman location, State of Colima, and were obtained from different citrus hosts species. The frequency of 17 haplotypes among strains of CLas from the states of Nayarit, Jalisco, Colima and Michoacán was analyzed; in Colima 14 haplotypes were determinated, while in Michoacan all strains were identified in one haplotype. These results indicate a large genetic diversity among the strains of CLas present in the Central Pacific region in Mexico.
Designing Complexity: The Methodology and Practice of Systems Oriented Design
Authors: Sevaldson Birger
Published: February 2023

This book addresses one of the most pressing issues of our time: How can we design for, with, and in service of the complex world we live in? How can we be useful as designers in a rapidly changing world due to technological, political, and social processes, as well as climate change and nature destruction? Designers have some beneficial skills for planning with complex systems in mind, yet some old habits need to be overcome. Design's traditional purpose and role has been to solve problems, find order, organize, and simplify. Yet, the concept of designing complexity goes against these established beliefs because complexity cannot be designed away. So, instead, we present ways to live with, influence, and benefit from complex systems. There is no one "right" way presented in this book. Instead, many experiences, approaches, and perspectives are collected and presented. The process this book offers is a methodology called Systems Oriented Design (SOD). SOD is a design methodology and practice primarily geared toward understanding and working with complex systems. Several systems theories influence it, yet it remains true to its origin, the core of designing. SOD is a living and adaptable methodology. Though it is based on design thinking and design methodology, it is easily adapted and applied by anybody working with complex change processes.
Internet as a Meeting Place for Spouses: Homogamy, Assortative Mating and Online Dating in Contemporary Italy
Authors: Arosio Laura
Published: February 2023

This article studies the places where spouses met for the first time in Italy. The focus is on online settings in the most recent marriage cohorts (2000-2009 and 2010-2016). The aim is to investigate trends over time in the use of the Internet as a meeting place and to explore whether Internet dating can affect the rules of assortative mating and homogamy. Information about first marriages is analyzed to focus on highly engaged relationships. A quantitative approach is used and bivariate and multivariate analyses are conducted. The data used for the analyses come from the national representative survey "Family, social subjects and life cycle" carried out by the Italian National Institute of Statistics (Istat) in 2016 and made available in 2020. The results allow a preliminary quantification of the phenomenon and document an increase in online dating in Italy (from 0.4 percent of spouses who first met online in the marriage cohort 2000-2009 to 2.5 percent in the cohort 2010-2016). The data support the idea that online contexts show homogamy paths not different from those that characterize offline dating venues. Meeting an online partner doesn’t seem to imply heterogamy.
Perforations Tympaniques: Aspects Epidemiologiques et Etiologiques en Orl au Centre Hospitalier Universitaire Sylvanus Olympio de Lome au Togo
Authors: Winga Foma , Essobiziou Amana , Hervey Reoulembaye Djim , Gérémie Ananidjin , Uziel Boko , Bathokédéou Amana
Published: February 2023

Objectif : décrire les aspects épidémiologiques et étiologiques des perforations tympaniques. Patients et Méthode: Il s’est agi d’une étude rétrospective descriptive des perforations de la membrane tympanique au service d’ORL du centre hospitalier universitaire Sylvanus Olympio de Lomé allant du 1er Janvier 2021 au 31 Mai 2022. Etaient inclus tous les dossiers des patients dont la plainte ou l’une des plaintes se rapportait à l’oreille, avec entre autres, une perforation tympanique à l’examen otoscopique. Les données ont été traitées et analysées par le logiciel SPSS 28.0. Résultats : 153 dossiers ont répondu aux critères d’étude. L’âge moyen des patients était de 29 ans avec une étendue de la variable de 9 mois à 83 ans. Le sexe masculin a été rapporté dans 79 cas avec un sex-ratio   de 1,1. Les patients exerçant une fonction libérale représentaient 34% des cas. Le motif de consultation était une otorrhée purulente dans 40,5% des cas. L’otoscopie avait montré une perforation unilatérale dans 83,7% des c as dont 43,8% des cas à droite. Cette perforation était non marginale dans 79,2% des cas et non ponctiforme dans 56,7% des cas. Les perforations étaient dues à l’otite moyenne aigue dans 51% des cas, à l’otite moyenne chronique suppurée simple dans 24,2% des cas et aux traumatismes dans 22,8% des cas. Conclusion: la perforation tympanique est souvent due à l’otite moyenne aigue chez les patients jeunes consultant pour une otorrhée purulente dans le contexte d’exercice des auteurs.

 

Objective: To describe the epidemiological and etiological aspects of tympanic perforations. Method: A descriptive retrospective study of perforations of the tympanic membrane presenting in the ENT department of the Sylvanus Olympio university hospital in Lomé from January 1, 2021 to May 31, 2022. All records patients whose chief complaint or one of the complaints was ear related including a tympanic perforation on otoscopic examination, were considered and included in the data collection. Data was processed and analyzed using SPSS 28.0. Results: 153 files met the study criteria. The average age of patients was 29 years old with a variable range between 9 months 83 years. The male gender was reported in 79 cases with a sex ratio of 1.1. Patients exercising a liberal profession represented 34% of cases. The main reason for consultation was purulent otorrhea in 40.5% of cases. Otoscopy had shown a unilateral perforation in 83.7% of cases including 43.8% of cases on the right ear. This perforation was non-marginal in 79.2% of cases and irregular in 56.7% of cases. Perforations were following acute otitis media in 51% of the cases, simple chronic suppurative otitis media in 24.2% of the cases and traumatic injury in 22.8% of the cases. Conclusion: Tympanic perforation is often due to acute otitis media, particulary in young patients.
resposta de Cortes Constitucionais Latino-americanas à COVID-19:
Authors: Denari Gomes de Mattos Karina , Balbi Guilherme , Mastroianni Kirsztajn Laura
Published: February 2023

O artigo apresenta um estudo de caso exploratório sobre a resposta de cortes constitucionais latinoamericanas à COVID-19 em cenários políticos adversos com foco nas experiências de Brasil e México. A partir da análise da jurisprudência e de entrevistas com ativistas de Direitos Humanos e pesquisadores de think tanks latinoamericanos, busca-se refletir sobre as escolhas estratégicas que tais órgãos enfrentam sobre posicionar-se ou não em cenários de crise, frente a trade-offs como o apoio da opinião pública, desafios de implementação decisória e a manutenção de unidade e coerência de posicionamento dentro do próprio Judiciário. Conclui-se que, mesmo quando presentes desafios persistentes de implementação, tais decisões representam importante estímulo e reforçam pressões institucionais para a reação política em momentos de crise. Todavia, para as cortes, não são tão evidentes os benefícios relacionados ao fortalecimento da legitimidade social e de seus papéis institucionais.
Roztropność humanistyczna a psucie wiedzy. Dyskusja z koncepcją „epistemic values” z pozycji kulturoznawczo zorientowanej filozofii nauki
Authors: Skórzyńska Agata
Published: February 2023

W tekście autorka podejmuje dyskusję z koncepcją „cnót epistemicznych” Lindy Trinkaus Zagzebski, przyjmując punkt widzenia kulturoznawczo zorientowanej filozofi i nauki oraz socjologii wiedzy. Zwraca uwagę, iż projekt epistemologii ukierunkowanej na wartości etyczne, promujący takie kategorie jak zaufanie czy autorytet poznawczy, nie jest w stanie skutecznie rozwiązać problemu zaufania do twierdzeń nauki, ponieważ — mimo takowych deklaracji — nie rozwija założeń o kolektywnym pochodzeniu poznania naukowego. Sięgając do kategorii kolektywu myślowego (Ludwik Fleck) czy ideału wiedzy naukowej (Stefan Amsterdamski), autorka artykułu pokazuje, iż samo oparcie koncepcji poznania naukowego na indywidualistycznie pojętej etyce nie wystarcza wobec złożoności osiągnięć współczesnej nauki. Jednym ze źródeł nieporozumienia jest jej zdaniem redukcyjnie odczytana przez autorkę Epistemic Values kategoria fronetyczności, która w tekście zostaje skonfrontowana z reinterpretacjami pojęcia phronesis na gruncie humanistyki po tak zwanym zwrocie ontologicznym (a więc w propozycji między innymi Andrzeja W. Nowaka i autorki artykułu). Problemem ilustrującym staje się tu zagadnienie konsensu naukowego — korzystając z rozpoznań filozofi i nauki i społecznych studiów nad nauką i technologią, starano się pokazać, że konsens naukowy rodzi się w efekcie kolektywnych procesów, uzależnionych od dominujących w nauce stylów myślowych (za Ludwikiem Fleckiem). Dziś jednym z elementów hegemonicznego stylu myślowego staje się zjawisko „psucia wiedzy” (za Colinem Crouchem), które powoduje, iż problem fronetyczności w nauce (w tym w humanistyce) powinniśmy rozumieć przede wszystkim jako etyczne zobowiązanie do upowszechniania wiedzy na temat społecznych uwarunkowań konsensu naukowego, a nie jednostkowych dyspozycji do jego przyjęcia.
La concepción positiva de la laicidad como negación del propio concepto de laicidad
Authors: Blando Giovanni
Published: February 2023

El artículo tiene como objetivo analizar el concepto de laicidad ‘positiva’ o ‘sana’ apoyado por las jerarquías eclesiásticas señalando su confusión con el concepto sociológico de secularización y su incompatibilidad con dos valores fundamentales del Estado Constitucional de Derecho: libertad e igual consideración y respeto.
La libertad de expresión y las redes sociales
Authors: Valiente Martínez Francisco
Published: February 2023

El auge de las nuevas tecnologías ha propiciado una revolución en la comunicación humana, que ha pasado a ser global, masivamente multilateral y esencialmente digital. Regular la actividad online es indispensable para proteger a los internautas, pues las grandes empresas multinacionales propietarias de las aplicaciones que predominan en Internet diseñan unas políticas de uso que condicionan el ejercicio de nuestros derechos fundamentales, de un modo muy particular nuestra libertad de expresión. Las distintas alternativas para regular el funcionamiento de los proveedores de estos servicios y conseguir un modelo normativo equilibrado y viable a nivel internacional es, por lo tanto, un reto que no puede posponerse más.
The Importance of Carefully Evaluating Breast Masses During Pregnancy
Authors: Maia Ana Filipa , Solinho Mariana , Vicente Costa Rita , Alves Olga , Nogueira Madalena
Published: February 2023

N/a.
Factors affecting the flipped classroom in the educational context of Vietnam
Authors: Xuan Tran Thi Huong , Thanh Nguyen Bao Hoang , Nhi Nguyen Thi
Published: February 2023

In the context of the implementation of the 2018 General Education Program, teachers are required to implement a teaching model oriented to the development of students’ quality and competence. Teachers are encouraged to adapt the flipped classroom model of teaching in schools as its advantages are suitable for novel teaching strategies. This study focuses on analyzing factors affecting the application of this model in the teaching and learning process by collecting feedback from 351 teachers from various cities in Vietnam. The questionnaire included Likert-type questions analyzed by IBM SPSS Statistics version 20 for quantitative analysis and an open question for qualitative analysis with context and personal information. The research-oriented factors focus on the group of potential internal factors (perception, proficiency, desire and readiness of teachers) and the group of external factors (infrastructure, facilities and support resources, training programs). The results showed that those factors include the school’s infrastructure and information communication technology (ICT) condition, the teacher’s ICT competence as well as competence-related teaching and assessment methodologies and the students’ internet access conditions. Finally, the study offers suggestions on how to apply this model in teaching practice to meet the requirements of educational innovation in Vietnam.
PENGARUH MAHASISWA FAKULTAS ILMU AGAMA ISLAM (FIAI) TERHADAP KEGIATAN KEAGAMAAN MASYARAKAT DI SEKITAR UNIVERSITAS ISLAM INDONESIA
Authors: Irfandi Ahmad Hayu , Nugraha Ilham Bayu , Purwanto Muhammad Roy
Published: February 2023

Mahasiswa memiliki tanggung jawab dalam meneruskan kepemimpinan dalam skala kecil (masyarakat) maupun skala besar (bangsa dan Negara). Dikarenakan, mahasiswa yang mengenyam pendidikan di perguruan tinggi sangat berperan untuk memberikan pengaruh kepada masyarakat. Di sinilah mahasiswa harus bekerja keras dan berperan sebagai agen perubahan, agar terciptanya kualitas masyarakat yang lebih baik. Maka dari itu mahasiswa harus mampu berkontribusi dan bersosialisasi di masyarakat secara nyata. Seperti yang selama ini kita ketahui bahwasannya mahasiswa merupakan penyambung lidah rakyat dan agent of change dalam berbagai bidang. Sebagai generasi muda yang akan datang mahasiswa menyimpan potensi yang cukup besar bagi kelanjutan pembangunan masyarakat yang bersifat fisik maupun non-fisik terutama pada masyarakat disekitar tatkala masih mengenyam pendidikan di perguruan tingginya. Terlebih pada era milenial ini, mahasiswa sering dianggap telah kehilangan jati dirinya sebagai agen perubahan sosial terutama dalam hal dakwah. Berdasarkan kenyataan tersebut, penelitian ini melihat implementasi nilai-nilai kemasyarakatan yang mengedepankan kebermanfaatan dan pengaruh adanya mahasiswa Fakultas Ilmu Agama Islam di Yogyakarta di beberapa tempat, Yaitu masyarakat sekitar lingkungan kampus Universitas Islam Indonesia. Riset ini fokus pada masalah pertama, tingkat keberpengaruhan mahasiswa Fakultas Ilmu Agama Islam terhadap kegiatan keagamaan masyarakat di sekitar kampus. Kedua, perubahan yang dibawa mahasiswa FIAI terhadap bentuk kegiatan keagamaan disekitar kampus. Ketiga, gambaran peran mahasiswa dalam peningkatan kegiatan keagamaan yang ada di sekitar kampus. Keempat, Respon masyarakat terhadap kegiatan keagamaan yang dilakukan bersama mahasiswa Fakultas Ilmu Agama Islam. Penelitian ini merupakan penelitian lapangan dengan pendekatan sosiologis. Mengingat jenis penelitian ini adalah lapangan, maka dalam pengumpulan data, peneliti menggali data-data yang bersumber dari lapangan, yaitu mahasiswa Fakultas Ilmu Agama Islam dan Masyarakat yang tinggal disekitar Universitas Islam Indonesia.
BRAND IMAGE FAKULTAS ILMU AGAMA ISLAM (FIAI) DALAM PERSPEKTIF MAHASISWA
Authors: Hikmah Nailia Nurul , Nufus Fihayatin , Herawati Fara , Fahmi Rizqi Anfanni
Published: February 2023

Brand image perlu dimiliki oleh perguruan tinggi yang menyangkut reputasi universitas dalam memberikan pelayanan dan fasilitas kepada mahasiswanya. Terutama Fakultas Ilmu Agama Islam yang merupakan salah satu fakultas tertua dan juga merupakan satu-satunya fakultas keislaman di Universitas Islam Indonesia. Dengan demikian, perspektif mahasiswa terhadap brand image fakultasnya menjadi faktor penting untuk meningkatkan reputasi fakultas. Adapun tujuan dari penelitian ini adalah mengidentifikasi persepsi mahasiswa terhadap brand image Fakultas Ilmu Agama Islam. Melalui identifikasi brand image fakultas dalam perspektif mahasiswa dapat mempengaruhi citra dan nama baik fakultas pada khususnya dan universitas pada umumnya melalui 5 variabel (nilai utilitas, nilai hedonis, nilai hubungan, kualitas hubungan merek, dan resonansi merek). Penelitian ini menggunakan jenis pendekatan kuantitatif deskriptif dengan metode survey menggunakan google form. Objek wawancara adalah mahasiswa aktif Fakultas Ilmu Agama Islam Universitas Islam Indonesia. Adapun hasil penelitian menunjukkan bahwa faktor-faktor prediktif positif mempengaruhi perspektif mahasiswa terhadap brand image Fakultas Ilmu Agama Islam.
Assessment of Wind Speed Statistics in Samaria Region
Authors: Kolesnik Sergei , Rabinowitz Yossi , Byalsky Michael , Yahalom Asher , Kuperman Alon
Published: February 2023

SStatistical characteristics of the wind speed in Samaria region of Israel have been analyzed by processing 11 years of wind data provided by the Israeli Meteorological Service, recorded at 10 m height above the ground. The cumulative mean wind speed at measurement height was shown to be 4.53 m/s with standard deviation of 2.32 m/s. Prevailing wind direction is shown to be char-acterized by cumulative mean azimuth of 226° with standard deviation of 79.76°. The results were extrapolated to 70-meter height in order to estimate wind characteristics at hub height of a me-dium-scale wind turbine. Moreover, Weibull distribution parameters were calculated annually, monthly and seasonally, demonstrating a good match with histogram-based statistical repre-sentations. Shape parameter of the Weibull distribution was shown to reside within a narrow range of 1.93 to 2.15, allowing us to assume a Rayleigh distribution, thus simplifying wind tur-bines energy yield calculations. The novelty of the current paper is related to gathering wind statistics for a certain area (Samaria) we are not aware of any published statistics regarding wind velocity and direction in this area. The data may be interesting for potential regional wind energy development in which the obtained Weibull distribution can be used in calculations of expected power generation of particular turbines with known power dependence on velocity. We also point out that the fact that realistic wind velocity statistics is well described by an analytic formula (Weibull distribution) is not trivial, and in fact the fit may have been poor.
VULNERACIÓN DE DERECHOS HUMANOS Y REDES SOCIALES EN MÉXICO
Authors: Villanueva Flores Ruperto
Published: February 2023

El dominio de la tecnología ha permeado tanto a generaciones actuales como anteriores, por el uso de teléfonos celulares, computadoras, softwares, redes sociales. Todo esto ha permitido, con un aparente consentimiento por parte de los usuarios, que grandes compañías dispongan y/o manejen información privada. El objetivo de la investigación fue determinar si los Ministerios Públicos adscritos a la Fiscalía General del Estado de Chihuahua, Zona Norte, en México, como usuarios de redes sociales, vulneran el Derecho a la Privacidad de Datos Personales de personas investigadas. La metodología que se utilizó aborda una estrategia cualitativa, para determinar si se está vulnerando el derecho a la Privacidad de Datos Personales de usuarios de redes sociales, debido a la utilización de otro derecho como lo es la libertad de expresión. Se corrobora la incidencia entre el uso de redes sociales y el Derecho a la Privacidad de Datos Personales. Se utilizó un enfoque cualitativo, ya que se analizó el desarrollo del uso de redes sociales respaldado con el Derecho a la Libertad de Expresión en contraposición con la vulneración al Derecho a la Privacidad de los Datos Personales.
LOCALIZATION OF INDDUSTRIAL PRODUCTION AS A FACTOR OF INDASTRY REVIVAL OF UKRAINE
Authors: Sudarkina Svitlana
Published: February 2023

The current state of machine-building production in Ukraine for a number of objective and subjective reasons is very difficult - production volumeshave decreased several times over the past 30 years, and in some industries - simply disappeared. In addition, the old markets were lost and the newones did not appear, the equipment was worn out by more than 60-70%, the staff left the production and so on. At the same time, the need for productsof the machine-building complex in the country remains. We need to service utilities, transport and all infrastructure, not to mention the renewal andmodernization of all these and other industries. Meeting needs at the expense of foreign companies and firms is a short-sighted policy that can befollowed only for a short time or in the complete absence of their capabilities. At the same time, Ukraine has all the conditions for the rapid revival ofindustrial production on a new technical and technological basis. Therefore, the resumption of industrial production is one of the priority tasks that mustbe implemented in modern Ukraine. This is due to a number of interrelated and conditioned socio-economic, scientific, technical and technologicalfactors that make up a holistic system. Among the market factors, it should be noted the need to implement some protectionist measures that would helpcompanies to renew faster and enter to modern productions. Such measures include the recently adopted Law on Localization, №3739, the essence andproblems of which are discussed in this article.
FRANCHISING AS AN EFFECTIVE MODEL OF DOING INTERNATIONAL BUSINESS AND PROSPECTS OF ITS DEVELOPMENT IN UKRAINE
Authors: Sunigovets Olga , Konshyna Hanna
Published: February 2023

relations. The essence of franchising and its modern development is considered. The concept of franchising and franchising network, its importance inmodern forms of international business are given and the classification of franchising to the main features is carried out. The existing opportunities forthe development of franchising in Ukraine in comparison with the leading countries and the most effective realization of its potential for socio-economicdevelopment are analyzed. The importance of international franchising as an effective model of doing business is determined, the requirements for theconditions of its development are established, the analysis of the possibilities of its development in Ukraine from the point of view of variousinternational ratings is carried out. The necessity is revealed and the main priority directions of creation the conditions for realization of the internationalfranchising are given. The stages of franchising are systematized, the existing obstacles to ensuring its implementation and recommendations forimprovement from the point of view of ensuring the competitiveness of domestic subjects of international business in the implementation of the franchisestrategy to enter foreign markets are identified. The effectiveness of management of modern international business is determined by the possibility ofrealizing to access the foreign markets, the availability of different sources of income and the ability to implement different areas of internationalbusiness, which is reflected in the growth of business. It is proved that an important feature in the implementation of franchising as an effective modelof modern international business is the available potential and compliance of the conditions of development of business structures, which are precedesof the choice and belief of its implementation. This study will make possible the assessing of trends and general needs of enterprises in the implementation of the franchise model in order to ensure, above all, their effectiveness, implementation of effective strategies of managing of the entryinto foreign markets. Recommendations for international franchising development are determined on the basis comparative study of the developmentof franchising in the leading countries, an analysis of well-known world`s ratings and they are aimed of creating the prerequisites of developingfranchising in Ukraine.
METHODOLOGICAL RECOMMENDATIONS REGARDING THE ORGANIZATION OF THE INTELLECTUAL POTENTIAL MANAGEMENT SYSTEM OF THE MACHINE-BUILDING ENTERPRISE
Authors: Marchuk Lesia
Published: February 2023

In today's conditions, sustainable development and globalization processes significantly affect the state of the world economy, and its development isdetermined by the level of use of intellectual potential. The most important and significant process is the intellectualization of not only the economyand production, but also management, which in turn is responsible for highly qualified staff and continuing education. Intellectual potential in themanagement of the enterprise plays a very important role, because it has a number of specific features: skills, abilities, competencies, labor andintellectual resources, knowledge, ideas, technologies and more. The basis for the formation of the intellectual potential of enterprises is the staff.Therefore, there is a scientific task - to analyze the indicators that affect the results of managing the intellectual potential of enterprises in the engineeringindustry. Intellectual resources in the process of creative activity are undergoing significant changes: the growth of psychological stress, the replacementof values, worldviews, social orientations. This forces management to apply new moral, ethical and economic incentives to subordinates to improvecreative work and motivation. This is what requires guidelines for the organization of the management system of the intellectual potential of the machinebuildingenterprise. The most effective way to manage intellectual potential is step-by-step, because at each stage the goals and needs of the componentsare taken into account. Analysis of global trends in modern enterprises has shown that the most important concept is human resource management. Thearticle analyzes the methodological approaches to the management of intellectual potential, which proved that today there is no single and most accuratemanagement system. Therefore, our own methodological recommendations for the intellectualization of management were developed and proposed.
LOGISTICS SERVICES MARKETING STRATEGY IN ENTREPRENEURIAL ACTIVITY: PRICING AND DISTRIBUTION POLICY
Authors: Pererva Petro , Kobielieva Tetiana , Kosenko Andriy , Kosenko Oleksandra , Tkacheva Nadezhda
Published: February 2023

The article proves that marketing logistics is the planning, operational management and control of physical flows of materials and finished products,starting from the places of origin of flows of raw materials, components, etc. and ending with the delivery of final products to consumers, in order tomost effectively meet their demands. Marketing logistics is based on combining the ideas of marketing and logistics, which addresses issues ofmarketing pricing and marketing policy distribution. Also here the tasks of assortment loading of production on the basis of the portfolio of ordersformed by marketing services are solved, strategies of pricing and distribution of the goods are formed, technology of optimum movement ofresources and products is defined, standard requirements to packing, quality of products are developed. resources, equipment and premises. Moderninformation technologies play a significant role in marketing logistics: computers, cash terminals; identical coding of goods; satellite tracking systemsfor transportation; electronic data exchange and money transfer. The cost of marketing logistics is up to 30-40% of the cost of finished products.A classification of logistics costs has been developed, which will serve as a basis for the development of methods to identify, evaluate, analyze, planand reduce logistics costs in domestic enterprises. In addition, there is an opportunity to take a more reasonable approach to setting prices for logisticsservices and improve the marketing policy of distribution of enterprise products. The relationship between marketing and logistics, the use of which inpractice allows to optimize the policy of marketing distribution of products and improve the strategic position of marketing pricing. The mostsignificant differences between marketing and logistics are identified and classified.
PREREQUISITES FOR THE FORMATION AND LOCALIZATION OF NARROW PLACES IN THE PRODUCT DISTRIBUTION SYSTEM
Authors: Kostiuchenko Lesia , Harmash Oleh , Perederii Nadiia , Sokolova Natalia
Published: February 2023

The key elements of logistics management of the distribution system of goods, in particular international trade networks, are studied. The parameters of evaluating the efficiency of individual distribution channels of goods in the distribution system are considered. The concept of "bottleneck" in the distribution network in general and individual distribution channels in particular has been clarified. The causes of bottlenecks in the distribution system channels, the points of localization of possible current restrictions - bottlenecks in the distribution system of goods are analyzed and the ways of their elimination are investigated. The results of research, methods and recommendations can be used to form the optimal distribution strategy of modern companies in conditions of unstable demand and under the influence of other negative factors. In view of the above, the task is to study in more detail the key elements of logistics procurement management for the defense sector in space and time and to develop practical recommendations for logistics management of the organization of defense procurement. Therefore, the aim of the study is to analyze the structure of the distribution network in conditions of unstable demand and under the influence of other negative factors in order to identify bottlenecks in the distribution system and find ways to eliminate them optimally.To achieve this goal, the following were investigated: priorities and guidelines for logistics management of the distribution system of goods from the manufacturer to the network of end users; structure and configuration of distribution channels in the distribution system as a subject of optimization; causes of bottlenecks in the distribution system channels and ways to eliminate them. Thus, logistics solutions localized in the field of distribution are a "trade-off" relationship with the sphere of production. That is, the field of distribution focuses on two important issues: first, the rationale and formation of distribution channels; secondly, the design and implementation of physical distribution of goods. In addition, the logistics management of the distribution system should be understood as the management of the process of moving goods from producer to end consumer, or their network, integrated with relevant financial, information and service flows to ensure a mix of logistics tasks.
CHANGES IN THE SMALL BUSINESSES DEVELOPMENT STRATEGY IN CONNECTION WITH THE WORLD COVID-19 PANDEMIC
Authors: Tverska Yana , Litvinenko Marija
Published: February 2023

The article examines enterprises belonging to small and medium-sized businesses, their main market advantage is determined. The impact of Covid-19 on the activities of certain sectors of the Ukrainian economy is analyzed in detail. A list of measures was provided to stabilize and improve the financial situation of small and medium-sized businesses after their release from quarantine. The components of the recovery strategy and special tactics to prevent the closure of small and medium-sized businesses have been determined, based on information received, in fact, from Ukrainian entrepreneurs. The consequences of the coronavirus pandemic significantly affect the economic development of the state, leading to a slowdown in the global economy as a whole. This can lead to the extinction of business activity in Ukraine, which will automatically lead to an increase in unemployment. It was considered which business areas have become and can become relevant and promising during the Covid-19 pandemic in various fields of activity, namely: food, health, medicines, clothing, second-hand goods, household goods, sports goods, work and business online in the direction of personal improvement, calming, teaching children. It is shown that the main business strategy during the Covid-19 pandemic is online business, a list of the most expedient and promising areas of online business during quarantine is given. Also in Ukraine, during the quarantine, an information panel was created as a tool for monitoring socio-economic indicators for the period of the quarantine, which will determine the time required to restore the economy. The current data of this panel have been analyzed, its informativeness has been established, which allows experienced small and medium-sized businesses to track the statistics of changes during quarantine and assess for themselves all the risks and benefits of their own industry. The study shows the importance of improving the business climate for realizing entrepreneurial potential in the context of the Covid-19 pandemic. It is necessary to further conduct research on existing obstacles and analyze relevant and effective strategies for the development of entrepreneurship in Ukraine. As a result, they proposed their own vision of the impact of the Covid-19 pandemic on the development of small and medium-sized businesses.
IMPROVEMENT OF FINANCIAL MANAGEMENT MECHANISMS FOR SMALL BUSINESSES IN UKRAINE
Authors: Petrykiva Olga
Published: February 2023

The article is devoted to solving the problems of finding ways to improve the mechanisms of financial management of small businesses in Ukraine. It is revealed that solving financial problems is the main direction of successful functioning of small enterprises in Ukraine, which consists in implementing a set of measures to bring a small enterprise in line with the chosen strategy of its financial and economic development. The characteristic features of managing the financial resources of small businesses that characterize them among other legal entities and individuals operating in Ukraine are highlighted, and it is concluded that all these features are somehow inherent in small businesses in Ukraine and should be taken into account when improving the mechanisms of their financial management. The author's classification of sources of formation of financial resources of a small enterprise is proposed, taking into account the peculiarities of their functioning. It is proved that attracting sources of financing at small enterprises has a single strategic goal, namely: the development of their financial potential to ensure sustainable functioning in the crisis conditions of Ukraine. The tasks of forming the financial potential of a small business entity are systematized, which are integrated for the effective implementation of the main goal in its key aspects. It is found out that the implementation of tasks in the system of strategic financial management is carried out through reasonable management of financial flows between a small business entity and internal and external sources that arise during operational activities. A sequence of stages of the process of developing a strategy for forming the financial potential of a corporation based on special principles is formed. It is concluded that the effective implementation of the strategy for forming the financial potential of a small business entity at these stages will ensure their well-established financial and economic growth in the crisis conditions of Ukraine.
EXCISE TAX: CHANGES IN THE TAXATION OF TOBACCO PRODUCTS
Authors: Koptievа Hanna , Andriienko Katerina
Published: February 2023

Modern excise policy in the conditions of active transformation of the tobacco market should provide a sufficient level of tax revenues to the budget, regulate the consumption of tobacco products and its alternatives, prevent illicit trafficking in counterfeit and smuggled tobacco products, take into account the development of national tobacco legislation. experience of Community countries in the field of excise tax. Domestic excise policy faces difficult tasks - to ensure the optimal balance between achieving the goals of filling the budget and regulating the consumption of various categories of tobacco products, to support national tobacco producers and ensure public health, to pursue a course of European integration. Excise tax on tobacco products produced on the territory of Ukraine traditionally forms the largest share in the structure of excise taxes, while their very taxation is carried out at specific and ad valorem rates. The purpose of the article is to study the impact of raising the specific excise rate on the receipt of excise tax in the budget. The main changes in the taxation of tobacco products in Ukraine and the consequences for national producers of tobacco and tobacco products are analyzed. In order to study the impact of raising the specific excise tax rate on excise tax revenues to the budget, a forecast model of the dependence of tax revenues from excise tax to the budget on sales of tobacco products and the average excise tax on a pack of cigarettes. The article proposes a plan for a gradual increase in the specific excise tax on tobacco products for 2021-2025. To test the hypothesis, a forecast model for the sale of cigarettes is built, taking into account the increase in the tax burden until 2025. reducing the shadow sector and supporting domestic producers. A further vector of research should be directed towards improving the excise policy to strengthen control over the production and circulation of tobacco products and their electronic labeling.
SYSTEM FOR IMPROVING STAFF MOTIVATION
Authors: Kucheriava Anna , Gorovyi Dmytro
Published: February 2023

At the present stage of economic development, the issue of a system for improving personnel motivation at the enterprise is quite relevant. After all, in today's conditions, the problem is the imperfection of the motivational system in enterprises, the lack of funds that could be directed to the development of the motivational system of the enterprise, another important problem is that domestic organizations almost do not pay attention to the motivation of their subordinates. Also, when choosing a motivation system, you can face the problem of its effectiveness among employees. Usually, material incentives are more popular, and at the present stage of development, more and more attention is paid to non-material incentives, which makes it possible, with the right approach to each worker, to unlock his maximum potential, which will reveal not only him as a person, but also improve the effectiveness of the organization. Since the system of personnel motivation is of great importance for each existing company, this process has been studied by such foreign and domestic scientists as A. Maslow, G. Hertzberg, E. McGregor, E. Mayo, M. V. Vroom, O. S. Ivanilov and others. The end of the 70s-beginning of the 80s of the last century was quite rich in the study and analysis of human behavior, and thanks to this, the world saw the works of General Motors, IBM, Japanese "Quality Circles", and a significant contribution to the study of the personnel motivation system was made by domestic scientists: M. Volsky, G. Tsekhanovetsky, T. F. Stepanov, I. V. Vernadsky, I. Ya. Franko, A. A. Getman, V. M. Shapoval, G. A. Shvidanenko, V. G. Vasilkov, N. P. Goncharova, S. F. pokropivny, N. I. sklyaruk, O. I. slavuta, L. I. Shvab and others. But the current economic stage requires new implementations due to the rather difficult situation that arose due to the COVID-19 pandemic in early 2020 in Ukraine, which is why this article has an actual message about improving the staff motivation system. The purpose of this work is to systematize theoretical provisions and substantiate practical recommendations at the present stage of Economics on the development of a motivational system in enterprises. This will allow you to introduce improvements to the motivational systems that organizations use. Thus, we can conclude that the problem associated with the motivation system occupies one of the main places in the work of the organization, because a successful motivation system for employees of the organization is primarily an increase in employee productivity, as a result of reducing production time and increasing the company's profits. Management should understand and properly organize the motivation system for employees, because it is the right motivation system that makes it possible to maximize the potential of the worker. Therefore, if the motivation system is developed, it allows the enterprise to be competitive and increases the final result of its activities.
COST CONTROL IN THE SYSTEM OF ANALYTICAL SUPPORT OF ENTERPRISE MANAGEMENT
Authors: Yakymenko-Tereshchenko Natalia , Zhadan Tatiana , Zhuk Ugor , Golovenko Maria
Published: February 2023

The content of cost management based on modern scientific approaches to its organization was determined. In article was emphasized on the elements of the cost control system. The main elements of the system of internal cost control of LLC "Pharmacy of low prices Kharkiv" include: allocation of responsibilities, effective procedures for authorizing transactions, timely documentation of transactions, actual control over property and documentation, independent validation. The definition of the concept and classification of transaction costs of pharmaceutical retailers are given. Оrganizational and methodological support of internal control of the company's transaction costs includes: organization of accounting of transaction costs, gathering of information on the transaction costs of the enterprise; accumulation and storage of information about the transaction costs of the enterprise; produce indicators for assessing the transaction costs of the enterprise and their analysis; selection of the form of presentation of the results of control of transaction costs of the enterprise, allocation of the directions of use of the results of control of transaction costs of the enterprise; making management decisions based on the results of control. Тhere are stages of the control procedures for the transaction costs of the enterprise: verification of the legality and correctness of the reflection of transaction costs in accordance with accounting rules and regulations and regulatory legal acts, comparison of the correctness and reconciliation between primary documents and accounting registers, validation of the allocation of transaction costs for a certain period, verification of their validity and appropriateness, determination of the correctness of analytical accounting of transaction costs and preparation of appropriate reports.