bluuebunny/crossref_metadata_2025 huggingface dataset:
P.Fam.Tebt. 9 + P.IFAO III 13: New Insights into Herodes’ Family
Authors: Borrelli Bianca
Published: January 2024

This article offers a new edition of a contract of a loan repayment in the dossier of the family of Herodes, which can now be read in its complete form thanks to the join between P.Fam.Tebt. 9 and P.IFAO III 13. Based on a palaeographical and linguistic analysis of the subscriptions to the contract, an attempt is made to define the level of literacy of the family members involved in the transaction. It is proposed that another papyrus, P.IFAO III 1, belongs to the dossier.
A List of Men and Artabas from Soknopaiou Nesos
Authors: Gonis Nikolaos
Published: January 2024

Edition of a list with names and numbers of artabas from Soknopaiou Nesos.
Another Customs Receipt
Authors: Gonis Nikolaos
Published: January 2024

Edition of a customs receipt for the 3% tax, housed in the Bodleian Library.
Effects of Stimulus Rate and Periodicity on Auditory Cortical Entrainment to Continuous Sounds
Authors: Momtaz Sara , Bidelman Gavin M.
Published: January 2024

The neural mechanisms underlying the exogenous coding and neural entrainment to repetitive auditory stimuli have seen a recent surge of interest. However, few studies have characterized how parametric changes in stimulus presentation alter entrained responses. We examined the degree to which the brain entrains to repeated speech (i.e., /ba/) and nonspeech (i.e., click) sounds using phase-locking value (PLV) analysis applied to multichannel human electroencephalogram (EEG) data. Passive cortico-acoustic tracking was investigated inN = 24 normal young adults utilizing EEG source analyses that isolated neural activity stemming from both auditory temporal cortices. We parametrically manipulated the rate and periodicity of repetitive, continuous speech and click stimuli to investigate how speed and jitter in ongoing sound streams affect oscillatory entrainment. Neuronal synchronization to speech was enhanced at 4.5 Hz (the putative universal rate of speech) and showed a differential pattern to that of clicks, particularly at higher rates. PLV to speech decreased with increasing jitter but remained superior to clicks. Surprisingly, PLV entrainment to clicks was invariant to periodicity manipulations. Our findings provide evidence that the brain's neural entrainment to complex sounds is enhanced and more sensitized when processing speech-like stimuli, even at the syllable level, relative to nonspeech sounds. The fact that this specialization is apparent even under passive listening suggests a priority of the auditory system for synchronizing to behaviorally relevant signals.
Modeling Effects of Variable preBötzinger Complex Network Topology and Cellular Properties on Opioid-Induced Respiratory Depression and Recovery
Authors: Chou Grant M. , Bush Nicholas E. , Phillips Ryan S. , Baertsch Nathan A. , Harris Kameron Decker
Published: January 2024

The preBötzinger complex (preBötC), located in the medulla, is the essential rhythm-generating neural network for breathing. The actions of opioids on this network impair its ability to generate robust, rhythmic output, contributing to life-threatening opioid-induced respiratory depression (OIRD). The occurrence of OIRD varies across individuals and internal and external states, increasing the risk of opioid use, yet the mechanisms of this variability are largely unknown. In this study, we utilize a computational model of the preBötC to perform several in silico experiments exploring how differences in network topology and the intrinsic properties of preBötC neurons influence the sensitivity of the network rhythm to opioids. We find that rhythms produced by preBötC networks in silico exhibit variable responses to simulated opioids, similar to the preBötC network in vitro. This variability is primarily due to random differences in network topology and can be manipulated by imposed changes in network connectivity and intrinsic neuronal properties. Our results identify features of the preBötC network that may regulate its susceptibility to opioids.
Structural Integrity Assessment on the Sustainability of an LNG Export Terminal
Authors: Lung Ting Kang , Ting Ding Sie , Yusop S. H. , Abg Junaidi A. A. S.
Published: January 2024

Natural gas reserves were discovered at offshore of Bintulu, Sarawak in late 1960s.  First Liquefied Natural Gas (LNG) project begin operation since 1983. Currently there are nine (9) LNG production trains with an export terminal of three (3) berths in operation. This paper presents structural integrity assessment of an LNG export terminal to ensure sustainability and continuous safe cargo delivery, which was originally intended to operate up to 2021.  Extension of service life avoid demolition of existing jetty, minimise construction activities and material used thus reduce CO2 and waste generation. Various inspection techniques such as visual inspection, underwater inspection, detail inspection with destructive test (DT) and non-destructive test (NDT) were conducted.  Detail analysis with StaadPro V8i software was performed to assess the jetty structure integrity at current stage and prediction on safe operation in future. The field inspection results show that 62% of concrete pile jackets experienced moderate to severe defects. Generally, the jetty concrete structure was found to be still in good condition with minor defects.  DT and NDT on the concrete structure indicated that the test results are within acceptable limits.  Surface corrosions were observed on miscellaneous steel structure. Structural analysis result indicates that the berthing velocity need to be reduced from 115 mm/s to 100 mm/s for safe berthing of 80,000 DWT vessel unless the piles capacity is reinstated. The study concluded that through proper repair and rehabilitation of existing piles and structures, jetty service life can be further extended for 20 years.
Statistical Analysis of Temporal Variations in Patterns of Rainfall and Temperature in the Klang Valley
Authors: Ramli Muhammad Khalid , Masbah Dani Irwan
Published: January 2024

Malaysia is in the equatorial zone and experiences hot and humid climates throughout the year. During the rainy season, floods may occur in some parts of Malaysia, including the Klang Valley. During the flood occurrences, the residents may need to leave their houses and move to relief shelters. This disaster may happen because of the continuous heavy downpour in the area. Both incidents can be connected to climate change, and one way to investigate this is to examine differences in daily rainfall and daily temperature patterns through time. Climate change is inevitable and one of the causes is known as 'anthropogenic' in which it is caused by human activities. Geological records can provide evidence of climate change. However, there has been little statistical research on climate change in the Klang Valley. Even official organisations like the Department of Irrigation and Drainage Malaysia (DID) and the National Water Research Institute of Malaysia (NAHRIM) have not conducted this area of study. The goal of this study is to evaluate climate change in the Klang Valley using statistical analysis of temporal rainfall patterns. The data collection and statistical analysis are two critical parts of this study. Rainfall and average temperature data were obtained from their respective departments and websites. These data were sorted and filtered accordingly to get a satisfactory value for the analysis. Then, the correlation test and analysis of variance were conducted to find the relation between these data points. The results of this analysis were used to determine whether the variations in rainfall patterns in the Klang Valley are caused by climate change or otherwise. In addition to this, the statistical outputs indicate that there is a statistically significant finding in both data sets in which the decreasing temperatures may result in increasing rainfall and warmer conditions may lessen the rainfall. Surprisingly, the findings contradicted the expected outcome of this study, and it is believed that external factors are the primary contributors to these findings.
Properties of Sustainable Concrete Consisting Crushed Eggshell Waste as Fine Aggregate Replacement
Authors: Muthusamy Khairunisa , Kamaruzaman Abidatul Munawwarah , Ruslan Hanis Nadiah , Ismail Mohammed A.
Published: January 2024

The excessive extraction of sand from riverbeds has adverse effects on river ecosystems and aquatic life. Simultaneously, the disposal of eggshells from certain food manufacturing facilities into landfills contributes to pollution. Incorporating crushed eggshells as a partial replacement for sand in concrete can reduce the demand for natural sand, thus decreasing the need for sand mining from rivers. The present research investigates the effect of crushed eggshells as partial sand replacement on workability, compressive strength, and splitting tensile strength of concrete. Five different concrete mixtures were tested, with crushed eggshells replacing sand at percentages ranging from 0% to 20% by weight. All specimens underwent water curing and were subjected to three tests: slump, compressive strength, and splitting tensile strength. The incorporation of eggshells, finer than sand, reduced workability but showed acceptable strength up to a 10% replacement rate. In conclusion, using eggshells as a sand substitute in concrete production can contribute to a cleaner environment and support river ecosystem sustainability.
Influence of Anodizing Parameters on the Morphological Characteristics of TNTAs
Authors: Aamina  , Hossen Md. Arif , Abd Aziz Azrina
Published: January 2024

TiO2 nanotubes arrays (TNTAs) were synthesized using the anodization method in ethylene glycol (EG)-based electrolyte with different percentages of ammonium fluoride (0.3, 0.4, and 0.5 wt.%) and water content (2.5, 5, and 7.5% vol%). All the samples were ultrasonically cleaned in acetone, ethanol, and deionized water, then dried in air and kept in an etching solution for a while before anodization. The two-step anodization was carried out, followed by thermal treatment at 450°C for the crystallization. The nanotube samples were characterized using FE-SEM analysis. The FE-SEM results showed that the largest tube diameter was 87.74±1.89 nm of the TNTAs prepared in the EG electrolyte with a composition of 7.5% water content and 0.5% ammonium fluoride. The longest tube length analyzed was around 5.3 µm of the TNTAs prepared in the ethylene glycol electrolyte with the composition of 2.5% water content and 0.4% ammonium fluoride percentage, exhibiting a highly ordered, compact honeycomb structure and thick single-walled structure.
The Performance of the Exclusive Motorcycle Lane (EMCL) in Reducing Fatal Crashes Among Motorcyclists after 20 Years of Operation
Authors: Abdul Manan Muhammad Marizwan , Mohamed Noordin N.F.
Published: January 2024

When the first exclusive motorcycle lane (EMCL) was built in the early 70s, and after it was entirely built along Kuala Lumpur to Klang in 1993, it was studied to be very effective in preventing crashes by up to 34%.  However, that was more than 20 years ago.  This study aimed to investigate the effectiveness of the current EMCL in terms of its potential to reduce fatal crashes among motorcyclists, its fatal risk factors, and its benefit-to-cost ratio to the government.  This study uses secondary data from the Royal Police of Malaysia (PDRM) and primary data from the second Penang Bridge highway.  The results show that EMCL is still an effective measure to reduce the fatalities among motorcyclists, with an effectiveness rate of 74% fatal reduction and a benefit-to-cost ratio of four times to the government. This study also finds that motorcyclists riding along EMCL who are not under substance influence, motorcyclists travelling during daytime and weekends (Saturdays and Sundays), and EMCL that are situated along Urban and EMCL with unpaved shoulders are predicted to be risky.  However, when measured with traffic volume, EMCL may or may not be effective when evaluated based on the number of its utilisation or exposure.  In conclusion, EMCL will save motorcyclists' lives and perform in the long term, albeit with strict enforcement of its usage and proper maintenance to accommodate safe motorcycle travel.
Enhancing Mortar Properties with Crushed Palm Oil Clinker as a Partial Fine Aggregate Replacement
Authors: Jamaludin Nur Farah Aziera , Muthusamy Khairunisa , Mohd Nasir Mohamad Shahirudin , Hilal Nahla Naji
Published: January 2024

The study investigated the feasibility of utilizing crushed palm oil clinker, a byproduct of the palm oil industry, as a partial substitute for fine aggregate in mortar. This initiative aimed to mitigate the environmental issues arising from sand mining and excessive disposal of palm oil clinker in landfills. Five different replacement percentages (0%, 10%, 20%, 30%, and 40%) were tested, with all specimens undergoing water curing.  The research outcomes revealed significant effects on mortar properties. As the proportion of crushed palm oil clinker increased, the flowability of the mortar diminished. Nevertheless, incorporating 10% crushed palm oil clinker resulted in improved compressive strength. Conversely, higher replacement percentages (20%, 30%, and 40%) led to a diminishing trend in compressive strength due to an increased porous structure and weaker bonding. Additionally, when higher replacement percentages (20%, 30%, and 40%) were employed, the water absorption of the mortar increased.  In summary, employing crushed palm oil clinker as a partial substitute for fine aggregate can help reduce waste disposal while conserving natural river sand resources. This approach offers a potential solution to address both environmental concerns and the need for sustainable construction materials.
Eigenfrequency Shift of Piezoelectric Backplate in Vibro-Acoustic Energy Harvesting
Authors: Mansor Muhammad Hatifi , Mohd Sani Mohd Shahrir , Hassan Mohd Firdaus
Published: January 2024

Noise is increasingly recognised as a serious, worldwide public health concern. Noise is a type of occupational hazard that can cause damage to hearing and other health effects in workers who are exposed to high levels of noise in their work environment. Traditionally, noise can be controlled and suppressed but recently, noise can be useful and converted into electrical energy. The process of converting noise or acoustic waves into electrical energy by using a quarter wavelength resonator tube embedded with a flexible piezoelectric backplate was used in this study. The results show the maximum output voltage of 1.41 V/Pa at 112 Hz and 0.44 V/Pa at 225 Hz in the experiment, and 1.44 V/Pa at 106 Hz and 0.41 V/Pa at 226.5 Hz with incident sound waves at 90 dB. A parametric study was then performed by adjusting the lumped pointed mass at the piezoelectric backplate to tune the resonant frequencies of the system and the optimal power output. The point mass has given significant change in the acoustic properties. The maximum output power increased from 20.4  at 112 Hz using a flexible back plate to 711  at 119.75 Hz. Various small power applications can benefit from the approach by reducing and absorbing specific low-frequency bandwidths of continuous noise in the environment.
Experimental Optimization of High-precision Turning Parameters of AL6061 Materials for Automotive Industry Based on Grey Relational Analysis
Authors: Puoza Julius Caesar , Zhang Tainyao , Uba Felix , Kuusana Yakubu , Ibrahim Awudu
Published: January 2024

This research article aims to explore the relationship between the machining parameters of a Slant Bed Turning Centre Computer Numerical Control (SB/C/CNC) precision lathe and surface microhardness, dimensional error and surface roughness of AL6061. A technique called the central composite design (CCD) method with 13 experiments was used to evaluate the surface microhardness, dimensional error, and surface roughness after a turning operation using a micro-grooved texture tool. Separate prediction models were developed for each of these characteristics using the response surface method (RSM) in order to find the optimal process parameters for each characteristic. The analysis of variance revealed that the prediction models for surface microhardness, dimensional error, and surface roughness were highly significant, with p-values less than 0.0001. The process parameters that resulted in the highest surface microhardness were a cutting speed (Vc) of 154.363 m/min and a feed rate (fz) of 0.231 mm/rev. On the other hand, the process parameters that led to the lowest dimensional error and surface roughness were Vc = 154.363 m/min, fz = 0.1389 mm/rev, and Vc = 152.081 m/min, fz = 0.1025 mm/rev, respectively. The multi-objective prediction model based on gray relational analysis showed an error range of 1.5% to 3.1% and a minimum gray relational degree value of 0.3503 within the feasible process parameter range. The accuracy of this multi-objective prediction model was higher, with a stronger response to the cutting speed Vc compared to the feed rate fz. The determined feasible process parameter range serves as a useful reference for engineers working with AL6061 materials in turning operations.
CT-FEA of Inhomogeneous Lumbar with Different Loadings of the Spinal Cage
Authors: Azmi Muhammad Shahruddin , Izham Munirah Mohamad , Jalil Muhammad Hilmi , Mazlan Muhammad Hazli
Published: January 2024

Interbody fusion has recently been successfully used to treat degenerative spinal instability. Without needing to test it in vitro, finite element analysis (FEA) was used to reflect the biomechanical interaction between lumbars and cages. However, the complex geometry of the lumbar region was not accurately modeled by the numerous studies that relied on homogenous, simplified models. This study aims to fill this knowledge gap by creating an inhomogenous lumbar model and using computed tomography finite element analysis (CT-FEA) to assess the biomechanical characteristics of a spinal cage implanted in the model. CT images were used to create a 3D inhomogenous lumbar model of L4-L5. In order to assess the biomechanical characteristics of the implanted cage, a spinal cage was inserted between the lumbar model, and the model was subjected to FEA with loads ranging from 500 N to 1200 N. As the load applied to the assembled model varied from 500 N to 1200 N, the results showed that the maximum principal's stress increased. With values of 12.33 MPa and 0.102 Pa, respectively, the von Mises stress for a load of 500 N had the lowest maximum and minimum values. At 1200 N of force, the highest stress was indicated by the maximum and minimum values of the Von Mises Stress, which were 30.37 MPa and 0.244 Pa, respectively. The stress distribution demonstrated that the inhomogeneous lumbar model was applicable and that using FEA could produce promising results. The significance of taking into account the spinal cages' biomechanical characteristics in non-homogeneous lumbar models is shown by this study. CT-FEA can be a valuable tool for assessing the biomechanical characteristics of spinal cages in non-homogeneous lumbar models. The significance of taking into account the spinal cages' biomechanical characteristics in non-homogeneous lumbar models is shown by this study.
Development of Ankle-Foot Orthosis Using Servo Motor with On-Off Control System for Drop-Foot
Authors: Ubaidillah Dr , Utomo Bagus Pribadi , Wulansari Pipit , Parahita Aristya Naziiha , Smaradhana Dharu Feby , Son Lovely
Published: January 2024

This research addresses the imperative need for a lightweight, compact, and efficient design of an Active Ankle-Foot Orthosis (AFO), with the potential for everyday use and enhancement of gait cycles in individuals with drop-foot. The proposed AFO employs a servo motor to generate ankle moments based on gait phase detection, ensuring low power consumption and a structurally lightweight configuration. The study encompasses a kinematic analysis of the gait mechanism utilizing a graphical method, facilitating the determination of the requisite force for the motor actuator. Additionally, a finite element approach is employed to assess the strength of linkages. The connecting mechanism utilizes Poly (methyl methacrylate) or PMMA board due to its lightweight nature and ease of fabrication. Based on the simulation result, the minimum safety factor of link bars was 1.8. While, based on the kinematic analysis, the minimum required torque that should be provided by the servo motor is 3.838 Nm. The servo motor serves as the active element within the AFO, and an on-off control system, driven by a rotary encoder detecting gait phases, governs the AFO's movement. Ankle joint angle readings obtained through AFO implementation exhibit values within the range of normal individuals. The entire control system operates with remarkably low power consumption, registering at 0.06 W over one running cycle. Based on these analyses, a prototype has been developed for further evaluation in patient trials, underscoring the potential efficacy and practicality of the proposed active AFO design.
Evaluation of Automotive Bio-Composites Crash Box Performance
Authors: Ang Xin Yi , Hassan C.S. , Soh S.Y. , Olugu E.U. , Abdullah N.F. , Yu L.J. , Abdul Aziz N.
Published: January 2024

In the automotive industry, sustainable materials, such as bio-composites, are progressively being adopted due to their lightweight feature, which reduces vehicle weight, fuel consumption and pollutants emissions. Bio-composites are renewable and biodegradable, making them more environmental-friendly. However, limited investigations into the use of bio-composites in crash box applications have indicated that they lack the impact strength to fully absorb collision energy. This study aims to compare the crashworthiness performance of crash boxes made from OPEFB fiber/epoxy and kenaf fiber/epoxy composites, with conventional steel and carbon fiber/epoxy using LS-DYNA quasi-static simulations. Six different crash box designs are proposed: square, hexagonal, decagonal, hexagonal 3-cell, hexagonal 6-cell, and decagonal 10-cell structure, to evaluate the effect of these designs on crash box performance. The results show that bio-composite crash boxes are inferior to traditional materials in terms of energy absorption and specific energy absorption, but they yield better performance in crush force efficiency. In terms of design, decagonal 10-cell structure produces the highest specific energy absorption and energy absorption for bio-composites. Hence, optimization is performed on the OPEFB fibre/epoxy decagonal 10-cell crash box, aiming to increase energy absorption capability by varying the thickness, perimeter, and length of the crash box. The design is optimized by increasing thickness and maintaining length and perimeter. Compared to the original design, the optimized design improves energy absorption by 59% and specific energy absorption by 19%. The optimized design is then subjected to both quasi-static and impact loading tests, revealing that the optimized OPEFB fibre/epoxy crash box design exhibits 44% lower energy absorption than steel under quasi-static load, but it demonstrates a 56% increase in crush force efficiency and a 6 % increase in specific energy absorption. Under impact load, it shows a 91% increase in specific energy absorption compared to the traditional square steel crash box.
DIGITAL BANKING STOCK PERFORMANCE: THE IMPACT OF COVID-19
Authors: I Gst. Agung Pramesti Dwi Putri  , Kho Jasmine Priscilla
Published: January 2024

The Covid-19 pandemic has catalyzed a dramatic change in entire banking operations. However, not a few banks have transformed into digital banks to continue providing top services to customers. This study aims to identify Indonesia's banking market reaction to the Covid-19 pandemic especially for digital banking industries. The market reaction is seen from the movement in stock prices and stock trading volumes. The research was conducted using qualitative research methods. The sample is PT Bank Jago Tbk. (ARTO) with observation period from January 2020 to December 2021. The results of this study indicate that the market reacts to information entering the market quickly. The speed of information entering the market also accelerates market reactions that occur. The market reacts negatively to negative events and reacts positively to positive events. In addition to confirming the efficient market theory, the results of this study also confirm the signal theory. The president's announcement of the first case of Covid-19 in Indonesia is a bad signal for investors regarding cash flow and the company's future. This study also found that stock prices and volume did not only react to Covid- 19 conditions but also corporate actions. Several corporate actions that have an impact on price movements and volume of ARTO stocks are the issuance of rights issues, changes in the company's business processes, and the entry of the new investors. Based on the results of this study, investors in the stock market can pay attention to certain events that can provide buy or sell signals.
Optimization of offset and cant angle winglet on remote control airplane using Taguchi – Particle swarm optimization
Authors: Junipitoyo Bambang , Suranto Putro Setyo Hariyadi , Pertiwi Fungky Dyan , Kusumadewi Tri Vicca , Rahmadi Apri , Salsabila Syifa’ Zain
Published: January 2024

Incorporating winglets into aircraft has been empirically proven to notably improve aerodynamic efficiency by reducing vortex-induced effects at the wingtips. However, conducting comprehensive investigations necessitates the exploration of numerous winglet factors and value variations. This study pertains to remote control aircraft winglets, focusing on manipulating cant angle and offset factors across four distinct values. Two primary objectives guide this research: firstly, the maximization Cl/Cdmax, and secondly, the minimization Cd₀. The Taguchi experimental design is employed to randomize the variations in offset and cant angle values systematically. These variations are then used to generate pivotal regression values in the subsequent particle swarm optimization (PSO). The variance analysis evaluates the impact of winglet-related variables on each research goal. Additionally, the winglet design incorporates the open-source XFLR5 software, an accessible resource for aeromodelling clubs in Indonesia. XFLR5 enables the investigation of aerodynamic parameters across various angles of incidence and plays a crucial role in this research. The results of this study reveal that the Taguchi method yields two distinct combinations of factor values, aligning with the two primary research objectives. Conversely, particle swarm optimization generates a combination that effectively addresses both objectives. A comparative analysis of the winglet factor combinations from Taguchi and PSO underscores the greater efficiency of the PSO method in optimizing winglet variations for two distinct objectives.
Efficiency and Accuracy of Scheduling Algorithms for Final Year Project Evaluation Management System
Authors: Loo Chang Herng , Toh M. Zulfahmi , Ab. Nasir Ahmad Fakhri , Kamaruddin Nur Shazwani , Ismail Nur Hafieza
Published: January 2024

Scheduling algorithms play a crucial role in optimizing the efficiency and precision of scheduling tasks, finding applications across various domains to enhance work productivity, reduce costs, and save time. This research paper conducts a comparative analysis of three algorithms: genetic algorithm, hill climbing algorithm, and particle swarm optimization algorithm, with a focus on evaluating their performance in scheduling presentations. The primary goal of this study is to assess the effectiveness of these algorithms and identify the most efficient one for handling presentation scheduling tasks, thereby minimizing the system's response time for generating schedules. The research takes into account various constraints, including evaluator availability, student and evaluator affiliations within research groups, and student-evaluator relationships where a student cannot be supervised by one of the evaluators. Considering these critical parameters and constraints, the algorithm assigns presentation slots, venues, and two evaluators to each student without encountering scheduling conflicts, ultimately producing a schedule based on the allocated slots for both students and evaluators.
Supervised Feature Selection based on the Law of Total Variance
Authors: Mustapa Nur Atiqah , Senawi Azlyna , Wei Hua-Liang
Published: January 2024

Feature selection is a fundamental pre-processing step in machine learning that decreases data dimensionality by removing superfluous and irrelevant features. This study proposes a supervised feature selection method based on feature relevance by employing the law of total variance (LTV). Specifically, the LTV is used to quantify the relevance of features by analysing the association between features and class label. Six classifiers were employed to evaluate the performance and reliability of the proposed method pertaining to classification accuracy. The results proved that a feature subset given by the proposed method has the capability to achieve comparable classification accuracy to the full feature set when just half or less than half of the original features are retained. The proposed method was also proven to be versatile as it can achieves adequate classification accuracy with all six classifiers with different learning schemes. In addition, a comparison with a similar type of feature selection method (AmRMR) shows that the proposed method yields a more accurate classification.
Increased GPC4 and clusterin associated with insulin resistance in patients with PCOS
Authors: Chen Zheng , Zeng Haixia , Huang Qiulan , Lin Cuiping , Li Xuan , Sun Shaohua , Liu Jian-ping
Published: January 2024

The aim of the study was to investigate the changes in serum glypican 4 (GPC4) and clusterin (CLU) levels in patients with polycystic ovary syndrome (PCOS) as well as their correlation with sex hormones and metabolic parameters. A total of 40 PCOS patients and 40 age-matched healthy women were selected. Serum GPC4 and CLU levels were compared between the PCOS and control groups, and binary logistic regression was used to analyze the relative risk of PCOS at different tertiles of serum GPC4 and CLU concentrations. Stepwise linear regression was used to identify the factors influencing serum GPC4 and CLU levels in PCOS patients. Serum GPC4 (1.82 ± 0.49 vs 1.30 ± 0.61 ng/mL, P < 0.001) and CLU (468.79 ± 92.85 vs 228.59 ± 82.42 µg/mL, P < 0.001) were significantly higher in PCOS patients than in healthy women after adjustment for body mass index (BMI). In the PCOS group, serum GPC4 was positively correlated with follicle-stimulating hormone, fasting plasma glucose (FPG), fasting insulin (FINS), homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride, and CLU (P < 0.05), whereas serum CLU was positively correlated with BMI, FPG, FINS, and HOMA-IR (P < 0.05). Multiple stepwise linear regression analysis showed that HOMA-IR was independently associated with serum GPC4, and BMI and HOMA-IR were independently associated with CLU (P < 0.05). Serum GPC4 and CLU levels were significantly higher in PCOS patients than in healthy women, suggesting that GPC4 and CLU may be markers associated with insulin resistance in women with PCOS.
ВЗАЄМИНИ ЛЕВА БАЧИНСЬКОГО І ВАСИЛЯ СТЕФАНИКА НАПРИКІНЦІ XIX – В ПЕРШІЙ ТРЕТИНІ ХХ ст.
Authors: Hanna PASKA Andrii KOROLKO
Published: January 2024

У статті досліджуються взаємини Лева Бачинського і Василя Стефаника наприкінці ХІХ – в першій третині ХХ ст. Простежено особливості формування світогляду та становлення суспільно-по- літичних поглядів обох діячів наприкінці ХІХ ст. Проаналізовано їхню співпрацю і практичну діяльність наприкінці ХІХ – на початку ХХ ст., яка зводилася до таких форм: участь у роботі з’їздів РУРП (УРП), радикальних народних віч, діяльності політичного товариства “Народна воля“; агітація на підтримку членів РУРП (УРП) під час виборів до австрійського парламенту та безпосередня участь у його роботі; сприяння у розгортанні українського січового руху; вшанування відомих діячів України, зокрема, Тараса Шевченка. Звернуто увагу на спонтанний характер взаємин Л. Бачинського і В. Стефаника у період Української революції 1914–1923 рр. Розглянуто громадська діяльність та співпраця діячів у структурі УРП (УСРП) періоду Другої Речі Посполитої.

Ключові слова: Лев Бачинський, Василь Стефаник, Східна Галичина, Русько-українська ради- кальна партія, Українська радикальна партія, епістолярна спадщина.
ПРОСТИТУЦІЯ ЯК СПОСІБ ВИЖИВАННЯ У РОКИ ПЕРШОЇ СВІТОВОЇ ВІЙНИ НА ПРИФРОНТОВІЙ ТЕРИТОРІЇ СХІДНОГО ФРОНТУ
Authors: Khoma Victoria
Published: January 2024

У статті висвітлюються питання проституції в роки Першої світової війни вздовж прифрон- товій території. Дана стаття розкриває маловивчену тему продажного кохання в умовах війни. Ме- тою статті є розкрити особливості поширення проституції в прифронтовому регіоні. Звернута увага на проблеми з якими стикалися жінки даної професії, розкрито попит та масовість на проституцію се- ред солдат. Важливу роль відведено спробам контролю за стихійною проституцією з боку місцевої вла- ди. Окремо висвітлено проблему маргіналізації великої кількості жінок, що через безвихідну ситуацію, змушені були ставати на таку дорогу. У дослідженні висвітлено роль “будинків щастя” для тилових воєнних та розкрито специфіку продажного кохання, особливо в умовах війни. У статті розкрито уяв- лення про прифронтову проституцію та поширення венеричних захворювань на фронті і на прифрон- тових регіонах. У підсумках визначено що проституція в умовах війни набула нових рис, а саме, купити “кохання” було більш доступно і дешевше ніж у довоєнних реаліях, адже в обставинах війни кількість солдат у прифронтових регіонах сприяла проституції.

Ключові слова: проституція, Перша світова війна, “будинки побачень”, венеричні захворюван- ня, маргінес, окупація, Східний фронт.
Análisis de tendencias y oportunidades para la creación de un programa de especialización en baja visión en Colombia. Un enfoque de vigilancia tecnológica e Inteligencia competitiva
Authors: Vargas Leal Viviana Marcela , Cervantes Díaz Martha , Idárraga-Ortiz Sergio Alejandro
Published: January 2024

En este informe se ofrece un análisis exhaustivo sobre las tendencias, oportunidades y capacidades en el campo de la baja visión en Colombia, con un enfoque en la vigilancia tecnológica e inteligencia competitiva. A través de la aplicación de metodologías de análisis cienciométrico y revisión de referentes nacionales e internacionales, el informe busca identificar la coherencia de la apuesta formativa del programa de especialización con las tendencias de investigación en el país, así como la dinámica inventiva relacionada con la temática de baja visión. Además, se destaca la importancia de la formación de especialistas en baja visión para contribuir al mejoramiento de la calidad de vida de las personas con esta condición visual, en línea con la misión de la Universidad Santo Tomás. En él se proporciona una visión integral de las posibilidades y desafíos en este campo, con el objetivo de orientar la planificación de programas de especialización en baja visión en Colombia.
Impact of coconut husk microcrystalline cellulose on the properties of geopolymer lightweight concrete
Authors: Rajalekshmi P. , Arul Jose J. Prakash
Published: January 2024

Geopolymer composite is an alternative to ordinary Portland cement. It has potential to avoid CO2 emissions to the atmosphere and to save raw materials during its manufacture. Flyash-based geopolymer concrete is altered by adding ground granulated bast-furnace slag (GGBS) to improve its fresh and hardened properties. Thermal ash aggregate is used as coarse aggregate to reduce geopolymer concrete density, improve strength, and conserve natural aggregate. Along with this matrix, coconut husk microcrystalline cellulose (MCC) is added to enhance its performance. In a M40 grade flyash and GGBS-based geopolymer concrete, MCC was used to replace fly ash at 1% to 5% levels. The geopolymer composites were tested for slump, compression, split tensile, water absorption, and acid resistance to determine the way coconut husk MCC interacts with lightweight concrete. An inclusion of 3% MCC with geopolymer composites improved 2% slump, 6% of compressive and split tensile strength. About 1.6% of water absorption was reduced in GPC matrix with 3% of MCC. Meanwhile 3% of MCC in geopolymer concrete improved, 4% of weight and 7% of strength under acid exposure. The research strongly supported utilizing MCC in geopolymer concrete to render it more sustainable and eco-friendlier.
Utilization of flours from hemp stalks as reinforcement in polypropylene matrix
Authors: Kılıç İbrahim , Avcı Büşra , Atar İlkay , Korkmaz Nesrin , Yılmaz Güngör , Mengeloğlu Fatih
Published: January 2024

Utilization of hemp stalks (HS) was investigated as filler and maleic anhydride-grafted polypropylene (MAPP) as a coupling agent relative to some mechanical, physical, morphological, and thermal properties of polypropylene (PP) composites. The test sample manufacturing used 10, 15, 20, 25, 30, and 35 wt% of HS and 0 wt% or 3 wt% of MAPP. Test specimens were manufactured by combining extrusion and injection molding processes. Results showed that incorporating filler and MAPP increased the mechanical properties significantly. The utilization of HS filler or MAPP provided an improvement of 11.7% (samples containing 35 wt% HS and 3 wt% MAPP) improvement in tensile strength, 44.2% (samples containing 35 wt% HS and 3 wt% MAPP) in flexural strength, and 60.2% (samples containing 30 wt% HS and 0 wt% MAPP) in impact strength compared to neat PP. The scanning electron microscopy analysis provided visual evidence that MAPP improved adhesion between the filler and the polymer matrix. This study showed that using hemp stalks in composite manufacturing provided good overall properties.
Salud mental en estudiantes de pregrado de la Facultad de Ciencias de la Salud de la Universidad Nacional de San Antonio Abad del Cusco, 2021
Authors: Perales Alberto , Saco Santiago , Izaguirre Manuel , Luna-Solís Ybeth , Arias Hugo , Padilla Alberto , Contreras-Pizarro Carlos , Salazar Anthony , Pinto Katherine
Published: January 2024

Sr. Editor,
Según la Organización Mundial de la Salud, uno de cada siete jóvenes padece de algún trastorno mental y el suicidio es la cuarta causa de muerte entre los jóvenes de 15 a 19 años. Recomienda intervenir sobre estos problemas, pues, de otro modo, los jóvenes estarán en riesgo de perjudicar no solo su salud integral sino su propia vida (1). En la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos, considerando que el grupo etario señalado en riesgo corresponde al de los estudiantes universitarios, se han realizado diversas investiga-ciones en poblaciones estudiantiles de pregrado (medicina, enfermería, obstetricia, nutrición y tecnología médica) cuyos resultados muestran prevalencias de problemas de salud mental superiores a las registradas en población general en cuanto a: conducta suicida, ideación ho-micida, indicadores de conducta disocial, problemas con el alcohol, depresión y ansiedad (2-6). Empleando la misma metodología de estas investigaciones, repetimos igual indagación en los alumnos de la Facultad de Ciencias de la Salud (FCS) de la Universidad Nacional San Antonio Abad del Cusco (UNSAAC), que consta de cinco escuelas académicas (medicina, odontología, farmacia y bioquímica, enfermería y obstetricia).
Diagnóstico de la variante conductual de demencia frontotemporal basado en estadios clínicos adaptado para países con baja educación: el caso de Perú
Authors: Custodio Nilton , Baca Seminario Fiorella , Carbajal Silva Juan Carlos , Montesinos Rosa
Published: January 2024

Demencia frontotemporal (DFT) es una condición neurodegenerativa escasamente reconocida en personas menores a 65 años de edad. El diagnóstico de DFT variante conductual (DFTvc) se basa en una entrevista clínica comprehensiva, complementada por una evaluación multidimensional (neurológica, cognitiva, neuropsiquiátrica, de biomarcadores e imágenes cerebrales) adaptada y validada a la población a estudiar; sin embargo, a pesar del incremento de su prevalencia en Latinoamérica y el Caribe, existe necesidad de herramientas estandarizadas y un consenso para el diagnóstico de DFTvc. El artículo intenta realizar una aproximación del enfoque de diagnóstico de DFTvc en escenario de paises con bajos y medianos ingresos, como el Perú.
Factores asociados al requerimiento de rehabilitación física en los peatones sobrevivientes de atropello en Perú, 2016 - 2021
Authors: Roman-Lazarte Victor , Roman Luz Angela , Chavez-Bustamante Sarai Gloria
Published: January 2024

Introducción. Los accidentes de tránsito (AT) son un problema de salud pública a nivel mundial, se estiman 1,3 millones de muertes anuales, y en los sobrevivientes deja secuelas traumáticas que pueden disminuir la calidad de vida. De las víctimas, los peatones lesionados representan el 22%. El objetivo del presente estudio fue determinar los factores asociados al requerimiento de rehabilitación física de los peatones lesionados por algún AT en el territorio peruano. Métodos. Se realizó un estudio observacional de corte transversal con los datos secundarios brindados por el Centro Nacional de Epidemiología, Prevención y Control de Enfermedades (CDC Perú) por medio de fichas epidemiológicas. Resultados. Se analizaron 14 186 registros que involucran a peatones lesionados por atropellamiento en carretera por algún vehículo motorizado entre el 2016 y el 2021. El 87,89% de las víctimas no requirieron rehabilitación posterior al suceso. Existe una mayor probabilidad de rehabilitación si el lesionado tiene una mayor edad y si la hora del accidente fue entre las 00:00 y 05:59 horas del día. Existe una menor probabilidad de rehabilitación si el accidente lo ocasiona un motocarro. Conclusiones. Existe una gran cantidad de accidentados jóvenes y adultos, sin embargo, la edad mayor se comporta como un factor asociado a la necesidad de rehabilitación, así mismo, el tipo de carretera y el tipo de vehículo causante influyen en el desenlace de la víctima.
Dermatitis herpetiforme en mujer joven de la Amazonía peruana
Authors: Ramírez-Calderón C. Daniel , Moreno Alfrando , Suncion-Calderon Abdul J. , López-Souza William J. , Flores-Echevarria Francisco , Zamora-Perea Hugo Percy , Ramírez-García Edgar A.
Published: January 2024

La dermatitis herpetiforme es una enfermedad autoinmune que se caracteriza por la presencia de lesiones vesiculares y prurito en la superficie extensora de las extremidades, nalgas y parte baja de la espalda. Se presenta el caso clínico de una mujer de 21 años, natural y procedente de Iquitos, que presentó múltiples vesículas dolorosas, pruriginosas, de base eritematosa y purulentas en ambos codos durante un mes. Posteriormente, estas lesiones se diseminaron a ambas rodillas y se agregó prurito intenso. La paciente experimentó períodos alternantes de remisión y exacerbación. La correlación del cuadro clínico, resultados serológicos y de biopsia, junto con respuesta terapéutica a la dapsona confirmaron el diagnóstico de dermatitis herpetiforme, con una evolución favorable y remisión de la enfermedad.
Síndrome neuroléptico maligno
Authors: Huarcaya-Victoria Jeff
Published: January 2024

El síndrome neuroléptico maligno (SNM) es una reacción adversa medicamentosa potencialmente fatal asociada comúnmente a medicamentos antipsicóticos. Este artículo presenta una revisión actualizada sobre el SNM, aborda su epidemiología, factores de riesgo, presentación clínica, posibles mecanismos subyacentes y tratamiento. Se busca mejorar el reconocimiento temprano, diagnóstico y manejo del SNM en el ámbito clínico para reducir su morbimortalidad. La búsqueda de literatura se realizó en PubMed, fueron priorizados ensayos aleatorizados, revisiones sistemáticas, estudios retrospectivos y reportes de caso. La incidencia del SNM ha disminuido en los últimos años, posiblemente debido a una mejor prescripción y titulación de la medicación. Los factores de riesgo incluyen el uso de antipsicóticos de alta potencia, dosis elevadas, incremento rápido de la dosis y uso de antipsicóticos inyectables de depósito. Se han identificado factores ambientales como la deshidratación, sujeción mecánica y temperaturas extremas. Algunas características psicopatológicas, como la agitación psicomotriz y la confusión, también se han asociado al SNM. Los factores hereditarios y los polimorfismos genéticos pueden influir en la susceptibilidad al SNM, pero se requieren estudios adicionales. La fisiopatología del SNM se relaciona con el bloqueo excesivo de los receptores dopaminérgicos, pero otros cofactores y sistemas neurotransmisores también podrían estar involucrados. El cuadro clínico del SNM se caracteriza por cambios en el estado mental, rigidez muscular, hipertermia, síntomas catatónicos y sudoración profusa. Existen diversas formas de tratamiento, desde medidas generales hasta intervenciones farmacológicas.
Efecto del estrés agudo y de la variación del estímulo masticatorio sobre el dolor nociceptivo somático en un modelo murino
Authors: Aguirre-Siancas Elías Ernesto , Alzamora-Gonzales Libertad , Colona-Vallejos Erasmo Honorio , Ruiz-Ramírez Eliberto , Condori-Macuri Rosa María , Lam-Figueroa Nelly Maritza
Published: January 2024

El estrés agudo se relaciona con la enérgica liberación de catecolaminas, citoquinas y cortisol, las cuales afectan la percepción dolorosa. La masticación estimula neuronas serotoninérgicas, dichas neuronas modulan a las vías neurales del dolor; sin embargo, la relación entre dichas variables aún está en proceso de entendimiento. Objetivo. Determinar el efecto del estrés agudo y del estímulo masticatorio sobre el dolor. Métodos. Experimento que se desarrolló en el bioterio de la Facultad de Medicina de la UNMSM. 40 ratones Balb/c machos de 8 semanas de edad. Los ratones fueron asignados aleatoriamente en 5 grupos iguales. A: semana 1 sin ningún estímulo y semana 2 estimulo masticatorio + estrés. B: semana 1 sin ningún estímulo y semana 2 estrés. C: semana 1 estrés y semana 2 sin ningún estímulo. D: semana 1 estímulo masticatorio + estrés y semana 2 sin ningún estímulo. E: control, sin ningún estimulo. El dolor se evaluó en los 5 grupos a los 7 y 14 días mediante la prueba de tiempo de retirada de la cola ante estímulo térmico. Resultados. Se empleó la prueba de ANOVA para la evaluación intergrupo, no hallándose diferencia significativa. Mediante la prueba de t student para muestras relacionadas se hizo la evaluación intragrupo donde se encontró diferencia significativa entre los 7 vs los 14 días tanto en el grupo A (p=0,029) como en el grupo C (p=0,03). Conclusión. El efecto del estrés agudo sobre la percepción dolorosa fue disminuida por el estímulo masticatorio en ratones Balb/c.
Síndrome de burnout y frecuencia de lesiones deportivas en futbolistas de clubes profesionales del Perú
Authors: Figueroa-Solórzano Miguel A. , Patiño-Bautista Katiuska V. , Arteaga-Cisneros Karen F. , Ñaña-Cordova Alvaro M. , Torres-Zegarra Betzy C. , Benavente-Chalco Xiomara C. , Runzer-Colmenares Fernando M.
Published: January 2024

Las lesiones deportivas son un riesgo habitual en los futbolistas. La lesión y el periodo de recuperación pueden causar la pérdida de actividad en competencias. En el sexo masculino las contusiones son más frecuentes que en el sexo femenino, presentándose una mayor cantidad de lesiones en miembros inferiores, sobre todo en ligamentos y músculos (1).  El desarrollo de estas lesiones trae como consecuencia falta de motivación, sentimientos de preocupación, y generación de cuestionamientos sobre el retorno a la participación deportiva debido al riesgo de volver a lesionarse y el miedo a no alcanzar el estado físico previo a la lesión. Esto a su vez provoca alteraciones del sueño, problemas de estudio y autoculpa. Por lo descrito, la práctica del deporte en la alta competencia podría provocar en el deportista desgaste profesional y síndrome de burnout, que puede ser evaluado mediante escalas de agotamiento, desperso-nalización y logro personal (2). Además, el burnout se caracteriza porque puede aparecer sin antecedentes de psicopatología debido a que su principal causa es el estrés.