bluuebunny/crossref_metadata_2025 huggingface dataset:
Cu(II)-Mediated direct 18F-dehydrofluorination of phosphine oxides in high molar activity
Authors: Tang Xiaoqun , Lv Shengji , Mou Zhaobiao , Liu Xia , Li Zijing
Published: January 2024

Background

The 18F/19F-isotope exchange method employing P(V)-centered prosthetic groups demonstrates advantages in addressing mild one-step aqueous 18F-labeling of peptides and proteins. However, the molar activity (Am) achieved through isotope exchange remains relatively low, unless employing a high initial activity of [18F]F−. To overcome this drawback, our work introduces a novel approach through a Cu-mediated direct 18F-dehydrofluorination of phosphine oxides. This method leverages the straightforward separation of the 18F-labeled product from the phosphine oxide precursors, aiming to primarily increase Am.

Results

Through a 19F-dehydrofluorination efficiency test, Cu(OAc)2 was identified as the optimal oxidative metal salt, exhibiting a remarkable 100% conversion within one hour. Leveraging the straightforward separation of phosphine oxide precursors and phosphinic fluoride products, the Am of an activated ester, [18F]4, sees an impressive nearly 15-fold increase compared to the 18F/19F-isotope exchange, with the same initial activity of [18F]F−. Furthermore, this Cu(II)-mediated 18F-dehydrofluorination approach demonstrates tolerance up to 20% solvent water content, which enables the practical radiosynthesis of 18F-labeled water-soluble molecules under non-drying conditions.

Conclusions

The direct 18F-dehydrofluorination of phosphine oxide prosthetic groups has been successfully accomplished, achieving a high Am via Cu(II)-mediated oxidative addition and reductive elimination.
Dietary novel alkaline protease from Bacillus licheniformis improves broiler meat nutritional value and modulates intestinal microbiota and metabolites
Authors: Yi Wuzhou , Liu Yanjie , Fu Shijun , Zhuo Jianshu , Wang Jiping , Shan Tizhong
Published: January 2024

Background

Different types of exogenous protease supplements have a positive impact on animal performance, but their effects on the nutritional value of meat and the gut microbial community of broilers have not been extensively studied. The objective of this investigation was to determine the impact of supplementation with a novel alkaline protease derived from Bacillus licheniformis (at doses of 0, 100, 200, 300, and 400 g/t) on the fatty acid and amino acid profiles, inosine monophosphate (IMP) levels, total volatile basic nitrogen (TVB-N) content found within the breast muscle, as well as the impact on the cecal microbiota and metabolites.

Results

Supplementation with 200–400 g/t of the novel protease resulted in a significant elevation in the concentration of essential amino acids (P < 0.001), flavor amino acids (P < 0.001), and total protein (P = 0.013) within the breast muscle. Results derived from the 16S rRNA sequencing and untargeted metabolomics analysis of the cecal content revealed that the novel protease reshaped the cecal microbial and metabolite profiles. In particular, it led to increased relative abundances of Bacteroides, Lactobacillus, Alistipes, and Eubacterium, while simultaneously causing a reduction in the metabolites of D-lactic acid and malonic acid. Moreover, correlation analyses unveiled significant relationships between distinct microbes and metabolites with the contents of IMP, fatty acids, and amino acids in the broiler's breast muscle.

Conclusion

In summary, the novel protease regulated the intestinal microbial community and metabolism, thereby inducing changes in the compositions of fatty acids and amino acids profiles, as well as IMP levels in broiler meat. These alterations significantly contributed to the enhancement of the nutritional value and flavor of the meat.

Graphical abstract
Association of Thyroid Dysfunction in Individuals ≥ 65 Years of Age With Subclinical Cardiac Abnormalities
Authors: Barasch Eddy , Gottdiener John , Buzkova Petra , Cappola Anne , Shah Sanjiv , DeFilippi Christopher , Gardin Julius , Kizer Jorge R
Published: January 2024

Context

The relationship between thyroid dysfunction and measures of myocardial disease in older individuals remains to be defined.

Objective

To evaluate the impact of thyroid dysfunction on structure and function of the left heart chambers and blood markers of cardiac disease.

Methods

Cross-sectional analysis of the Cardiovascular Health Study, a community-based cohort of older individuals recruited from 4 urban areas in the United States. Of 3163 participants studied, 2477 were euthyroid, 465 had subclinical hypothyroidism (SCH), 47 overt hypothyroidism (OH), 45 endogenous (endo) subclinical hyperthyroidism (endo-SCT), and 129 had exogenous (exo) SCT due to thyroid hormone supplementation. Participants underwent clinical evaluation, blood sampling and biomarker measurement, 2-dimensional and speckle tracking echocardiography for assessment of left heart myocardial deformation, circulating biomarkers of diastolic overload (NT-proBNP), fibrosis (sST2, gal-3), and cardiomyocyte injury (hs-cTnT).

Results

SCH was associated with higher NT-proBNP (beta = 0.17, P = .004), whereas OH was associated with higher hs-cTnT (beta = 0.29, P = .005). There were also suggestive associations of SCH with higher sST2, as well as endo-SCT with higher gal-3 and lower (worse) left atrial reservoir strain. Left ventricular longitudinal strain and end diastolic strain rate did not differ significantly from euthyroid participants in SCH, OH, or exo-SCT.

Conclusion

In this free-living elderly cohort, subclinical and overt hypothyroidism were associated with abnormalities of blood biomarkers consistent with diastolic overload and myocardial necrosis respectively, whereas subclinical hyperthyroidism tended to be associated with myocardial fibrosis and decreased left atrial strain. Our findings could represent stage B heart failure and illuminate distinct aspects of the pathobiology of heart disease related to thyroid gland dysfunction with potential clinical implications.
Niemieckie przedsiębiorstwa i marki w sektorze motoryzacyjnym w Polsce
Authors: Dyba Wojciech , Stryjakiewicz Tadeusz
Published: January 2024

Polska na przełomie XX i XXI wieku stała się miejscem lokalizacji wielu bezpośrednich inwestycji zagranicznych w przemyśle, ze znaczącym udziałem firm produkujących części motoryzacyjne. Duże zmiany nastąpiły również na krajowym rynku samochodowym – auta upowszechniły się jako środek komunikacji indywidualnej. Istotną rolę w tych przemianach odegrały podmioty niemieckie. Celem artykułu jest analiza ich oddziaływania na polski sektor motoryzacyjny (ze szczególnym uwzględnieniem jego przestrzennego zróżnicowania), z dwojakiego punktu widzenia: a) skali i rozmieszczenia inwestycji produkcyjnych w tym sektorze, b) popularności niemieckich marek na polskim rynku samochodowym. Punktem wyjścia analizy, obok studiów literaturowych, było przygotowanie baz danych o zlokalizowanych w Polsce zakładach oraz zarejestrowanych samochodach. Ze względu na geograficzny charakter badań, podstawowymi metodami prezentacji danych oraz ich pogłębionej analizy i interpretacji były metody kartograficzne (mapa rozmieszczenia, kartogram). Badanie pozwoliło wykazać, że niemieckie firmy stanowią około 1/3 ogólnej liczby wszystkich przedsiębiorstw sektora motoryzacyjnego w Polsce, a samochody niemieckich marek około 1/3 wszystkich krajowych rejestracji samochodów. Analiza rozmieszczenia przestrzennego niemieckich inwestycji wskazuje, że znajdują się one głównie w Polsce południowo-zachodniej i zachodniej (województwa śląskie, dolnośląskie, wielkopolskie, lubuskie i zachodniopomorskie), co wynika z bliskości granicy z Niemcami, dostępności transportowej oraz siły roboczej (w tym wykwalifikowanej w przemyśle). Rejestracje niemieckich marek dominują w Polsce zachodniej i północnej, co silnie uwarunkowane jest importem samochodów używanych z Niemiec na tych obszarach.
Statistical Analysis for Infrastructure Investment
Authors: Bragança Claudio Adriano
Published: January 2024

A linear regression analysis was performed using public data regarding the level of investment in the infrastructure sector and the growth of a nation’s GDP per capita for a group of 47 countries between 1995 and 2021. The findings were that, for all countries, each 1% of a nation’s GDP that is allocated in logistics infrastructure can increase the GDP per capita by 0.64% on the following year alone, and by 0.45% for middle-income countries. Both results are statistically significant considering a 95% confidence interval. Additionally, the article presents recommendations to project leaders, policy makers, and investors on how to maximize the returns on this type of investment.
Weighing the anchor: Lotmanian perspectives on the Fighting Poland symbol
Authors: Johnson Randall Lewis
Published: January 2024

Simple symbols occupy a unique position within the semiosphere, constituting the symbolic core of culture with their ability to condense cultural memory into nimble, economic forms. This simplicity facilitates persistence, allowing these elementary symbols to recur diachronically, penetrating multiple layers of cultural strata to emerge and flourish in new contexts and variations. A novel example of a symbol which illustrates these attributes is Znak Polski Walczącej – the Fighting Poland symbol. Created in 1942 by the Polish Underground State as a propaganda tool, this straightforward monogram, consisting of interconnected letters P and W, became the official hallmark of Polish resistance and is now a controversial de facto national symbol. This article employs the symbol as a case study to explore two Lotmanian symbolic concepts: the vast semantic capacity of simple symbols, and their dual nature as invariable/variable entities. Born out of a utilitarian need for simplicity in Nazi-occupied Warsaw, the efficient form of the Fighting Poland symbol was a pragmatic matter of life or death. However, further examination of its simple design also reveals an underlying archaic depth. This article argues that the Fighting Poland symbol, metonymically known as the kotwica (‘anchor’) owing to its distinct shape, can also be viewed as an “emissary” from earlier cultural epochs, namely ante-Nicene Christianity, which made use of anchor symbology during an era of persecution and upheaval. Ultimately, this article provides a new semiotic perspective on a historically active yet understudied symbol with past and present relevance.
A biosemiotic approach to landscapes: Alois Riegl’s theories of Kunstwollen and Stimmung revisited in the contexts of cognitive and evolutionary aesthetics
Authors: Chien Jui-Pi
Published: January 2024

This study explores the art historian Alois Riegl’s heuristic terms ‘Kunstwollen’ and ‘Stimmung’ in the contexts of cognitive and evolutionary aesthetics. To begin with, the author draws on notions of instinct theorized by George Romanes, Charles Darwin and Charles Peirce. They are shown to have embraced instinct and associated it with states of mindfulness, good reasoning and intelligence of survival. Another art historian, August Schmarsow, is also shown to have favoured instinctive attitudes and mental trials and errors as the sophisticated approach to art. These rigorous theorizations of instinct serve to expand Riegl’s idea that Kunstwollen suggests a relatively strong human will and desire for art. Further, to verify how viewers may attain states of Kunstwollen and Stimmung, the author draws on two landscapes (Landscape with Roman Ruins, 1536; The Heart of the Andes, 1859) to broaden viewers’ horizons. Viewers are advised to take full advantage of the medium made up by light, air and space so as to work out perspectives that favour their mental wellbeing and the reception of artworks. Finally, the author integrates Riegl’s theories into current research and emphasizes the necessity of unifying biological and cultural factors for the attainment of knowledge or original thinking in inquiries. In brief, Riegl’s theories appear fairly biosemiotic when we consider the rich evolutionary, psychological and semiological contexts surrounding the birth of his insights.
Ankylosing Spondylitis: Review of Clinical Features, Diagnosis, and Treatment
Authors: Markowiak Szymon , Wardęszkiewicz Marta , Jabłońska Wiktoria , Kasprzak Amelia , Świercz Maciej , Truchta Monika , Mańkowska Aleksandra , Kolano Agata , Pejas Anna
Published: January 2024

Introduction

Ankylosing spondylitis (AS) is a chronic inflammatory disorder affecting the spine and joints, leading to significant physical impairment. With a prevalence of 0.1-1.4%, AS holds significance in healthcare and socioeconomic contexts, therefore a thorough understanding is crucial for diagnosis and effective management. This article provides a current state of knowledge of the subject for clinicians and patients.

 

Review methods

English-language scientific literature found in PubMed, Web of Science, Google Scholar and Wiley databases (2015-2023) was used for the review. Articles were searched based on keywords. Each article was analysed for knowledge currency and relevance for use in the review.

 

Description of the State of Knowledge

After searching the articles, 20 articles were selected for final analysis. The data collected provides the latest information on ankylosing spondylitis.The etiology of AS has a strong association with the HLA-B27 antigen and research is being conducted on the association with HLA-15, IL-1, IL-23R, ERAP-1 and ERAP-2. Clinical manifestations include a broad spectrum of symptoms involving the musculoskeletal, ocular, respiratory, cardiovascular, gastrointestinal and psychiatric systems. Specific diagnostic guidelines have been published by ASAS and EULAR. Treatment includes NSAID, GCS and biologic drug therapy.

 

Summary

AS, with its complex etiology and diverse clinical manifestations, presents a diagnostic challenge to clinicians. The variable prognosis and complex treatment in AS requires physicians to continually update their knowledge.Early diagnosis and treatment initiation can improve the patient's prognosis.
Mobiliário urbano e arte pública em tempos de ressignificação do espaço público
Authors: Rocha Josielle Cíntia de Souza , Costa Fernando Araújo , Colchete Filho Antonio Ferreira
Published: January 2024

O ano de 2020 marcou o início da circulação da doença Covid-19 e uma nova forma de significarmos a vida nas cidades através de um esvaziamento emergencial e estratégico do espaço público. O objetivo desse artigo é analisar como o mobiliário urbano e a arte pública se notabilizam nesses tempos de pandemia como evidências materiais e simbólicas para se pensar em novas e antigas questões sobre a importância do espaço público para a constituição da esfera pública. Através de revisão de literatura, seleção de notícias nas mídias e na observação sistemática da vivência nos espaços, verifica-se que o mobiliário urbano e a arte pública se tornam peças-chave em ações recentes que se dão nos espaços públicos de várias cidades mundo afora, seja com a criação de novos elementos para suprir demandas por higienização, abrigo às intempéries e, sobretudo, para reivindicar a dimensão subjetiva como no caso da retirada de monumentos e esculturas de personalidades históricas controversas. Conclui-se que esse conjunto diversificado de elementos urbanos reivindica ao espaço público sua condição de arena para discussão de questões sociais que nele ampliam o status democrático.
A little brighter
Authors: Brown Clementine Rees
Published: January 2024

Clementine Rees Brown details some exciting developments for Dentaid The Dental Charity.
A helping hand
Authors: Waters Rebecca
Published: January 2024

Rebecca Waters suggests how best to be ready for your next inspection.
The importance of planning ahead
Authors: Caldwell Marie
Published: January 2024

Marie Caldwell highlights why it is essential for dental nurses to plan financially.
Telemanns Probe-Music für das Leipziger Thomaskantorat im Jahr 1722
Authors: Pfau Marc-Roderich
Published: January 2024

Vergleiche auch: Friedrich Noack: Johann Seb. Bachs und Christoph Graupners Kompositionen zur Bewerbung um das Thomaskantorat in Leipzig 1722-23. BJ 1913, S. 145-162

Christoph Wolff: Bachs Leipziger Kantoratsprobe und die Aufführungsgeschichte "Du wahrer Gott und Davids Sohn" BWV 23. BJ 1978, S. 78-94
Translations in Green: Colonialism, Postcolonialism, and the Vegetal Turn
Authors: Subramaniam Banu , Chatterjee Sushmita
Published: January 2024

ABSTRACT: This paper explores the coloniality of botany and its transnational genealogy by examining critical questions about agency of representation of botanical nomenclature. We use two examples— Hortus Malabaricus in the seventeenth century, and the Traditional Knowledge Digital Library (TKDL) from the twenty-first century—as bookends to examine the legacies of colonial botany. The Hortus is a comprehensive treatise developed by Hendrik van Rheede, the governor of Dutch Malabar, with the help of local botanists, doctors, and physicians. It remains one of the most comprehensive works on the flora of Asia and the tropics. The impetus for the Hortus was the desire for a catalogue of local plants so colonists could more efficiently extract the rich botanical resources in Asia. The TKDL is a digital repository of traditional knowledge of India. The impetus was to establish prior use of herbs and medicines in India and challenge global biopiracy of traditional Indian knowledge. Both the Hortus and the TKDL are repositories that respond to colonial regimes of power—the former for more efficient colonial extraction, and the latter to thwart it. Yet both are caught up in Western norms of botanical nomenclature. Drawing on feminist, postcolonial, and transnational studies, this paper examines the two moments to explore the enduring and shifting meanings of transnational colonial regimes of power.
Preparing Deans of Women: The Origins and Evolution of the Earliest Student Affairs Graduate Program
Authors: Smith Katie N.
Published: January 2024

Abstract: Higher education historians agree that the earliest direct antecedents to today’s student affairs professionals were deans of women (DOWs) and deans of men (DOMs), administrative positions that first arose in the 19th century. While DOWs were expected to supervise women students within newly coeducational environments, they professionalized the role—and the field of student affairs—by building professional networks, conducting scholarship, and pursuing graduate education. This historical study used archival records to explore the earliest student affairs graduate program, a professional diploma for DOWs at Teachers College, Columbia University, started in 1914. Findings explore the development of the diploma program throughout its lifespan, including its origins and the Teachers College context, diploma name changes, the first program-specific courses, and curricular changes. The Teachers College DOW professional diploma program ran for 30 years, ending after the 1944–45 academic year. This research provides insight into the history of student affairs as a field of study and illustrates the field’s long-standing values and philosophy, particularly the importance of supporting and advocating for minoritized students (ACPA, n.d.). Student affairs scholars and practitioners can use this history to better understand and articulate the context and purpose of their work today.
Community and Culture: Black Women’s Recollections of Their Experiences in College Transition Programs
Authors: Benson Janella D. , Wicker Paris D. , Barnes Imani , Winkle-Wagner Rachelle
Published: January 2024

Abstract: College transition programs offer early access to the collegiate experience, aid in the adjustment of students transitioning to college, and facilitate positive adjustments for Black women in their early college years. Less is known about whether Black women identify these programs as having a lasting influence on their college degree programs and careers. This critical oral history study of 24 Black alumnae contemplates their recollections of how college transition programs influenced their collegiate journeys within predominantly White and historically Black institutions. The Black alumnae emphasized the long-term importance of asset-based community cultural wealth approaches in transition programs that offered a head start to college. The alumnae noted that the transition programs provided forms of navigational, aspirational, and social capital. At PWIs, transition programs emphasized academic skills and social networks. At HBCUs, transition programs offered inclusion in the familial ethos of those campuses. In both institutional types, the women enjoyed gaining confidence and access to a hidden curriculum, which they retained throughout college and into their careers and lives.
The Collapse of the Riau Entrepôt in 1784 and the Rise of Singapore
Authors: Yok Khoo Chun
Published: January 2024

Abstract: The creation of a British trading station on the island of Singapore in 1819 and the ensuing 1824 Anglo-Dutch Treaty have traditionally been presented as causes of the division and decline of the Johor-Riau sultanate. This article proposes a less Eurocentric explanation, arguing that the collapse of the Riau entrepôt in 1784 set in motion a train of events that culminated a generation later with the emergence of an entrepôt on Singapore, which quickly became a major trading centre. This interpretation is based on the actions of the chief protagonists in 1784, when a rupture of Dutch-Bugis relations produced a divide between Riau’s Malay and Bugis factions, a conceptual parting of ways between sultanate and entrepôt, and an English fixation on Riau as the archetype of the straits entrepôt. Re-examining the collapse of Riau provides fresh perspectives on the origins of early colonial Singapore, while also drawing much needed attention to the continuities between the Singapore entrepôt and its antecedents in the Straits.
A Place of "Re-collect": Zainichi Experiences with/in Utoro, Japan
Authors: Han Min Wha
Published: January 2024

Abstract: As a memory place that exemplifies contemporary Zainichi experiences, the Utoro district in Kyoto, Japan, entails stories of Japan's colonial exploitation and postcolonial oppression, yet simultaneously reveals human hope, cooperation, and solidarity. First formed for the Korean workers and their families mobilized for the construction of a military airport during World War II, Utoro was left abandoned for decades in postwar Japan. Its Korean residents have suffered from continuous eviction suits, harassment, and violence including the most recent arson attack in 2022. At the same time, these intricacies of colonial origin and postcolonial controversy also invited networked grassroots efforts among the Japanese and Koreans to remember and reconstruct the place's sociohistorical meanings, resulting in the construction of the Utoro Peace Memorial Museum in 2022. This paper highlights the significance of Zainichi experiences with/in Utoro through an analysis of identity, discourse, and representation of the place. Drawing upon collective memory scholarship and adopting a theoretical framework of re-collection, the paper unravels complex meanings of a site in relation to human acts of remembering, making sense of, and finding significance to our past experiences with/in it. By situating visual and discursive voices of the Utoro community (Zainichi in Utoro ), such as its former residents' oral testimonies and museum displays, this study elucidates the significance of Utoro in Zainichi history. This paper argues that Utoro projects contradictory positionalities of Korean subjects as both integral and excess in the history of colonial and postcolonial socio-politics of ethno-racial Other in Japan.
The Tethered Fates of Japan's "Foreigner" Communities: Zainichi Koreans, Residency Provisions, and the COVID-19 Pandemic
Authors: Matthews Joel , Osaka Eiko
Published: January 2024

Abstract: This article explores how the fates of Japan's "foreign" communities—both "oldcomer" Zainichi Korean residents and "newcomer" foreign residents—have, especially since the 1990s, become tethered to one another. The authors argue that the postwar Zainichi Korean campaigns for legal, social, economic, educational, ethnic, constitutional, and welfare benefits have laid a foundation of "residency provisions" that the contemporary newcomer foreign community have also come to heavily rely on. However, access to such residency provisions by non-Japanese has increasingly come under attack from nativist and xenophobic groups such as the Zaitokukai and political parties such as the Japan First Party. More recently, waves of COVID-19 pandemic border closures and "states of emergency" incited a cultural and political environment in which "foreigners" became inextricably linked to the virus as a threat. Political and public support for border closures and stricter immigration controls coalesced with divisive and xenophobic movements that had primarily targeted Zainichi Koreans. The authors maintain this resulted in a shift towards exclusionary discourses directed at Japan's "foreigner" communities more generally. As social outgroups in contemporary Japan, Zainichi Koreans and newcomer foreigners are semantically, socially, and—most importantly—politically excluded through the Japanese/foreigner divide that continues to permeate Japanese self-consciousness. In conclusion, the case study of "IKUNO Tabunka Flat" is introduced as a model of Zainichi Korean grass-roots multiculturalism that attempts to overcome social division and isolation in Ikuno's "foreign" communities and assist in the creation of a more substantive and meaningful multicultural community in contemporary Japan.
The Multiple Layers of "Zainichi" Korean Chinese Diaspora Viewed from a Kaleidoscopic Perspective through the Prism of the Documentary Indelible
Authors: Kwon Hyangsuk
Published: January 2024

Abstract: In this paper, I analyze the documentary Indelible ( Chisuji , 2019), directed by Ryūichi Tsunoda (Seongwoo Kim). Depicting a "Zainichi" Korean Chinese in Japan, the documentary is a personal story of the journey of a man to find his father and, by extension, himself. Although it was produced with a focus on the family, particularly the father-son relationship, it also serves as a valuable historical account, illustrating structural realities in East Asia that continue to create diaspora. I elucidate the historical context of Korean Chinese in Japan and their migration and the difficulty of ascertaining the number of Korean Chinese living in Japan, discussing the connections between Korean diasporic histories across Korea, Japan, and China rooted in imperial occupation. I also explore, through intersectional perspectives, patriarchy, isolation of the elderly, female migration, and multilayered identification. I argue that the documentary serves as a prism through which the complexities of the Korean Chinese diaspora are revealed, not only deepening our understanding of the diaspora's historical trajectory and contemporary challenges but also illuminating the intersection and expansion of the identities of Korean Chinese in Japan.
Knowledge of Early Childhood Education Teachers Regarding Zero Waste-Based Learning in the Coastal Area of Kamal
Authors: Tiara Dinda Rizki , Pratiwi Eriqa , Rizki Safira Ajeng
Published: January 2024

Purpose – This article aims to elucidate the knowledge of teachers in early childhood education institutions in the coastal area of Kamal regarding Zero Waste-based learning.
Design/methods/approach – The research was conducted using a survey that focused on Zero Waste-based learning. Questionnaires were administered to 118 teachers in early childhood education institutions in the coastal area of Kamal. The data obtained were then analyzed using a one-sample t-test.
Findings – The research findings indicate that the majority of teachers possess a high level of knowledge regarding Zero Waste-based learning. However, there is a minimal difference in the number of teachers with high and low levels of knowledge. Many teachers utilize recycled materials and natural resources for teaching materials.
Research implications/limitations – This study can serve as a basis for providing training to early childhood education institutions, enabling them to improve Zero Waste-based learning and instill environmental consciousness in young children.
Practical implications – This research highlights the need for collaboration between all parties involved in environmental sustainability and schools to enhance teachers' knowledge of appropriate environmental education for children. Ultimately, this can help children gain knowledge about the environment through specialized or integrated daily lessons.
Originality/value –This study serve as a reminder to teachers in Kamal's coastal area to enhance their knowledge of Zero Waste as a tool for educating future generations of young children.
Paper type Research paper
How Moroccan Film Destination Attracts More Tourists
Authors: ALHADDAR M’barek , KUMMITHA Harshavardhan Reddy
Published: January 2024

With the different types of crises that the world was suffering from, management of a destination becomes more difficult than before, especially to develop the destination image. Many destinations are trying different ways to market their destinations, and one of those is the film industry. Film travel is considered a new fashion in visiting Morocco, and Essaouira is an attractive and sustainable destination. Motivating tourists to follow up the trend of travel with the film the DMO should use new ways of marketing, including sustainable projects, and taking care of the tourists’ perspectives. Several studies have confirmed the importance of film tourism in the destination image. The main objective of this study is to create a general process that can be used for any destination to make it an attractive and sustainable destination and to discover the importance of the film industry as a new way to market a destination and develop its image. Essaouira is the destination chosen for this study. Different research methods were used, an offline and online questionnaire with tourists and locals about their perspectives.

Research findings indicate that film tourism is a very important tool nowadays to promote a destination and will be very helpful to use it in the case of Essaouira. It is found that a lot of people got inspired by movies to travel, and in the case of this city, it is shown that film tourism along with sustainable tourism could improve the destination's reputation and affect the tourism sector positively.
The Portrait of Wellness Tourism during the COVID-19 Pandemic in Indonesia. A Case Study of Health Protocol Implementation at Green Kubu Café Bali
Authors: WIRAWAN Putu Eka , WIDHIARINI Ni Made Ayu Natih , SUDIARTA I Nyoman , YANI Ni Wayan Mega Sari Apri , NURUDDIN Nuruddin
Published: January 2024

Wellness tourism themed is currently a new trend because it aims to maintain the physical, mental, emotional, social, environmental, and spiritual aspects of tourists. This study is qualitative-descriptive research with data collection methods in the form of interviews, observations, and documentation. This study aims to look at the implementation of CHSE-based health protocols on tourist visits at Green Kubu Café, Tegallalang District, Gianyar Regency during the COVID-19 pandemic. The results of this study indicate that the implementation of the CHSE-based health protocol on tourist visits at Green Kubu Café has been going well, although it has not yet reached perfection. The satisfaction and loyalty of tourists who visit Green Kubu Café due to the implementation of the CHSE-based health protocol is also not meaningful or has no major influence, so the purpose of implementing the CHSE certification as stated by the Ministry of Tourism and Creative Economy is to provide guarantees to tourists for cleanliness, health, safety, and safety environmental sustainability has not been maximized.
Relationship between nurses' perceptions of distance in-service training activities and job motivations
Authors: Akgöz Çolak Sevim , Bodur Gönül
Published: January 2024

Background: The use of innovative technologies in continuing education activities in nursing is important in terms of increasing the quality of care.
Aim: This study aimed to determine the relationship between nurses’ perceptions of distance in-service training and job motivations.
Study Design: This study was designed as descriptive and correlational.
Methods:. This study population consisted of nurses working in rooted education-research and state hospitals that continue distance in-service training activities. The study were conducted an 703 nurses between October 2020 and January 2021. Data were collected with the “Information Form”, the “Distance In-Service Training Perception Scale” and the “Nurse Job Motivation Scale”.
Findings: The nurses’ total mean scale scores were 3.21±.97 for the “Distance In-Service Training Perception Scale” and 59.98±10.01 for the “Nurse Job Motivation Scale”. This showed that the nurses’ perception towards distance in-service training and job motivations were positively above the average. Nurses’ perception towards distance in-service training and job motivations were affected by gender, marital status, education level, type of institution, work years, type of employment, way of working, unit and choosing the profession and unit willingly. The nurses’ perception towards distance in-service training weren’t affected by distance or face-to-face education methods. It was determined that there was a weak positive relationship and a statistically highly significant relationship between the nurses’ perception towards distance in-service training activities and job motivations.
Conclusion: It is thought that the use of innovative teaching methods and materials in continuing training activities will contribute to the continuity of professional development and to increase job motivations.
Spiel, Spaß, … Vision!
Authors: Lotz Katinka , Soilihi Mzé Hassan
Published: January 2024

Das kooperative und partizipative Entwickeln von Konzepten, Prozessen und Räumen gewinnt auch in Bibliotheken zunehmend an Bedeutung. Dabei stellt sich für Bibliotheksteams ebenso wie für veränderungswillige Verwaltungen die Frage, wie ebensolche Partizipationsprozesse möglichst breit und mit Blick auf Zeit und Geld zugleich ohne größeren Aufwand angestoßen werden können. Der Beitrag wendet sich dieser Frage zu und zeigt einerseits, weswegen der Einsatz von spielerischen Ansätzen hierbei grundsätzlich zu konstruktiven Lösungen beitragen kann. Andererseits stellt er mit dem hochdrei – Visionenspiel der Kulturstiftung des Bundes ein digitales Werkzeug vor, das ein solches Planspiel explizit für Bibliotheken entwirft.
Adsorption and recovery of Cr(vi) from wastewater by Chitosan–Urushiol composite nanofiber membrane
Authors: Jie Xiaoyu , Shiu Bing-Chiuan , Wu Huazhong , Zhang Yuchi , Ye Yuansong , Lin Chunxiang , Fang Run
Published: January 2024

Chitosan (CS) is widely used in the treatment of wastewater containing metal ions. However, the poor stability in acidic aqueous solutions severely limits its application in many practical scenarios. In this work, a CS-based composite nanofiber membrane was prepared by electrospinning using urushiol, a natural biomaterial, as the cross-linking agent. The application of the CS-urushiol (CS-U) membrane in the adsorption and recovery of Cr(vi) in wastewater was systematically studied. The CS-U membrane showed great resistance to strongly acidic and oxidative environments, and the adsorption process combined two mechanisms of electrostatic attraction and redox reaction. Due to the nanoscale fibers, porous structure, and strong acid resistance, the CS-U membrane adsorbed Cr(vi) rapidly and efficiently in both batch and continuous modes. Moreover, the adsorption capacity and selectivity of the CS-U membrane for Cr(vi) could be maximized simultaneously by adjusting the solution pH, promoting the recovery of high-purity Cr2O3.
Experimental investigation on mechanical and tribological analysis of pineapple leaf (Ananas comosus) and sisal (Agave sisalana) fibers reinforced hybrid epoxy composites
Authors: Natarajan Ponnusamy , Mohanraj Manoharan , Kumar Murugesan , Sathish Selvaraj
Published: January 2024

In many industrial applications, natural-fiber-reinforced polymer (NFRP) composites are emerging as a strong substitute for composites based on synthetic fibers. The goal of this study was to examine the mechanical and tribological characteristics, including tensile, flexural, impact, wear, hardness, and water absorption, of hybrid epoxy composites reinforced with pineapple leaf and sisal fibers at various weight fractions. First, 5 % sodium hydroxide was used to treat the pineapple leaf and sisal fibers. With a composition of 0, 10, 15, 20, and 30 wt% of pineapple leaf and sisal fibers to the epoxy resin and its hardener mixture, which had a constant weight ratio of 70 %, hybrid composites were fabricated using the compression moulding process. To create a hybrid epoxy composite reinforced with pineapple and sisal fiber, epoxy resin was used as the binder. Different types of testing were performed on the hybrid composites following ASTM standards. The outcomes were contrasted with composites made from mono-pineapple and sisal fiber composites. In comparison to other composite samples, the 15:15 composite sample exhibited the best mechanical and tribological qualities, including the highest tensile strength, impact resistance, flexural strength, hardness, water absorption resistance, and wear resistance. Using a scanning electron microscope (SEM), the fiber/matrix adhesion was investigated. The 15:15 composite sample exhibits primarily mechanical and tribological properties, making the resultant composite material simpler to use in structural and automotive applications.
Artificial intelligence in paediatric endocrinology: conflict or cooperation
Authors: Dimitri Paul , Savage Martin O.
Published: January 2024

Artificial intelligence (AI) in medicine is transforming healthcare by automating system tasks, assisting in diagnostics, predicting patient outcomes and personalising patient care, founded on the ability to analyse vast datasets. In paediatric endocrinology, AI has been developed for diabetes, for insulin dose adjustment, detection of hypoglycaemia and retinopathy screening; bone age assessment and thyroid nodule screening; the identification of growth disorders; the diagnosis of precocious puberty; and the use of facial recognition algorithms in conditions such as Cushing syndrome, acromegaly, congenital adrenal hyperplasia and Turner syndrome. AI can also predict those most at risk from childhood obesity by stratifying future interventions to modify lifestyle. AI will facilitate personalised healthcare by integrating data from ‘omics’ analysis, lifestyle tracking, medical history, laboratory and imaging, therapy response and treatment adherence from multiple sources. As data acquisition and processing becomes fundamental, data privacy and protecting children’s health data is crucial. Minimising algorithmic bias generated by AI analysis for rare conditions seen in paediatric endocrinology is an important determinant of AI validity in clinical practice. AI cannot create the patient–doctor relationship or assess the wider holistic determinants of care. Children have individual needs and vulnerabilities and are considered in the context of family relationships and dynamics. Importantly, whilst AI provides value through augmenting efficiency and accuracy, it must not be used to replace clinical skills.
Public Authority Liability for Careless Failure to Protect from Harm
Authors: Steel Sandy
Published: January 2024

This article considers the UK Supreme Court decision in Michael v Chief Constable of South Wales Police. It explains the significance of the decision in terms of its affirmation of the principle that public authorities, in the case, the police, are subject to the same duties of care as private individuals in the tort of negligence. While offering some support for this ‘equality principle’, the article questions whether the principle is justifiably applied so as to restrict public authorities’ liability to that of private individuals.
STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
Authors: Zou Qiang , Tang Bo , Chen Xianchao , Zhang Chuang , Huang Yun
Published: January 2024

Serine/threonine kinase 11 (STK11), a tumor suppressor gene, exhibits frequent mutations in lung adenocarcinoma (LUAD). However, the specific molecular mechanisms by which STK11 mutations exert an influence on the biosynthesis of monounsaturated fatty acids (MUFAs) and subsequently affect ferroptosis in LUAD remain indistinct. In this study, bioinformatic analysis was employed to probe into the linkage between STK11 and key inhibitory genes of ferroptosis, namely SLC7A11 and SCD1, in LUAD tissues. Quantitative reverse transcription polymerase chain reaction was employed to assess the expression of STK11 in both wild-type and mutant STK11 LUAD cells, cell counting kit-8 to assess cell viability, and flow cytometry to detect apoptosis. A transmission electron microscope was utilized to observe mitochondrial morphology, and Western blot to ascertain the protein expression of STK11, ferroptosis-related proteins, and the enzyme SCD1 involved in MUFA synthesis. Oil red O staining was employed to test the distribution of lipid droplets in cancer cells, and a lipid quantification method to measure the content of MUFAs. Commercial kits were employed to assess the levels of lipid reactive oxygen species, malondialdehyde, glutathione, and Fe2+ in cells. The result revealed a negative correlation between STK11 and SLC7A11 as well as SCD1, with STK11 expression downregulated in mutant STK11 LUAD cells. Furthermore, STK11 mutations were found to suppress ferroptosis in LUAD cells by affecting MUFA synthesis. Subsequent rescue assays demonstrated that STK11 mutations hindered ferroptosis by impacting the synthesis of MUFAs in LUAD cells. This study provided evidence that STK11 mutations suppressed ferroptosis in LUAD cells by promoting MUFA synthesis, thus offering a novel research direction in the management of LUAD.
Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
Authors: He Na , Hong Aiwen , Zhao Kun , Zhang Zhefan , Wang Shengli , Jia Yaofei
Published: January 2024

Kashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 (SOX6) is important for forming cartilage. This study aims to explore the potential correlation between SOX6 single nucleotide polymorphisms (SNPs) and KBD risk for the first time. In the case–control study, 735 unrelated Chinese Han individuals were enrolled. The four mutation sites of the SOX6 gene (rs4539287 G/A, rs3203295 C/A, rs7928675 C/A, and rs10832681 A/G) were screened and genotyped on the Agena MassARRAY platform. The correlation between SOX6 SNPs and KBD risk was explored based on logistic regression analysis. The interaction between SNP and SNP was analyzed based on the multi-factor dimensionality reduction (MDR) method. Overall analysis revealed a remarkable correlation between rs7928675 and rs10832681 and the reduction of KBD risk (p < 0.05). Subgroup analyses further indicated that these two SNPs have a significant protective effect on KBD risk among participants aged ≤65 years, males, and non-smokers (p < 0.05). MDR displayed a marked interaction between rs3203295 and rs10832681. Our study revealed that SOX6 rs7928675 and rs10832681 are markedly correlated with a reduced risk of KBD in the Chinese Han population, providing a new direction for the prevention, diagnosis, and treatment of KBD.
Synthetic methodologies to access bioactive bis-coumarin scaffold: a recent progress
Authors: Bedi Pooja , Chaudhary Diksha , Bose Reshmi , Santra Soumava , Ansari Kashif R. , Kaur Rajbir , Pramanik Tanay , Sangtam Therola , Singh Ambrish
Published: January 2024

Heterocyclics particularly those containing oxygen and nitrogen atoms are unique precursors for the synthesis of various agrochemicals and pharmaceuticals. Bis-coumarins are well-known oxygen-containing heterocycles of great significance. The development of methods to prepare bis-coumarins is of great interest in synthetic organic chemistry because of their versatile importance in medicinal chemistry and chemical biology. Bis-coumarins are well known for their antibiotic, antimicrobial, anti-HIV, and antitumor activity. Due to the vast application of bis-coumarins, the synthesis of these heterocycles has attracted huge interest from researchers. In this review, we have summarized the diverse synthetic routes of bis-coumarin synthesis making use of different catalysts and solvents under versatile reaction conditions.
THE PREVALENCE AND SELECTED RISK FACTORS OF ORTHOREXIA NERVOSA DISORDER USING THE ORTO-15 TEST
Authors: MAJOCH MONIKA , HOMONCIK JUDYTA , MIKULEC ANNA , WĘGRZYN IZABELLA
Published: January 2024

Background. Although the phenomenon of orthorexia is widespread, its prevalence is hard to estimate. The aim of the study was to attempt to determine the occurrence of orthorexia in the study group and to assess the associations between selected risk factors and the prevalence of orthorexia. The survey was conducted in April 2023 among students of the Faculty of Health Sciences of the Academy of Applied Sciences in Nowy Sącz and via social media. A diagnostic survey method was employed using a questionnaire technique developed by the authors and the ORTO-15 questionnaire. Two cut-off points of < 40 and < 35 points were used. The Mann-Whitney U test, the Chi-Square test of independence and Cronbach’s alpha were carried out to analyse the results. Results and conclusions. The prevalence of orthorexia nervosa for a cut-off point of < 40 points was estimated at 77.78 %. Lowering the cut-off point to < 35 points resulted in a decrease in the prevalence of orthorexia in the study group to 24.69 %. For a cut-off point of < 40 points, a statistically significant relationship was obtained between the presence of orthorexia and the presence of chronic diseases. For a cutoff point of < 35 points, statistically significant relationships were obtained between the prevalence of orthorexia and BMI and between the presence of orthorexia and complaints. The other factors were not significantly different for any of the assumed cut-off points. Based on the results, the authors emphasize the need for further research on the use and creation of the useful adaptation of the ORTO-15 test in determining the prevalence and risk factors of orthorexia.