bluuebunny/crossref_metadata_2025 huggingface dataset:
Perfil e conhecimentos profissionais docentes no programa de estágio docente em um curso de pós-graduação em Química no estado de São Paulo
Authors: Gonçalves Costa Guilherme , Girotto Júnior Gildo
Published: April 2023

O perfil profissional do docente de nível superior é altamente complexo e compreende a mobilização de conhecimentos profissionais diversos. A literatura tem apontado aspectos que demonstram que docentes em início de carreira ainda carecem de preparo para a práxis, o que revela a importância de se investigarem os conhecimentos e identidades associados à participação destes profissionais em Programas de Estágio Docente (PED). Assim, o presente trabalho tem por objetivos compreender os perfis profissionais de pós-graduandos em um programa de pós-graduação em Química de uma universidade pública do estado de São Paulo e reconhecer as percepções destes sujeitos a respeito do PED desta instituição, reconhecendo também as dificuldades apontadas e a compreensão da atuação do professor supervisor. Para tal, construíram-se dois recortes de dados constituídos, respectivamente, por 72 e 34 discentes, cada um submetido a um questionário distinto, sendo o primeiro um questionário de perfil acessado por estatística descritiva, e o segundo um questionário de percepções acessado por Análise Textual Discursiva (ATD). As análises apontam pouca formação didático-pedagógica formal dos pós-graduandos, indicando um possível perfil de pouco preparo para a docência no nível superior de Química.
Formação e atuação de orientadores neófitos em Educação em Ciências
Authors: Massi Luciana
Published: April 2023

Este artigo tem como objetivo compreender a formação e a atuação dos orientadores neófitos emEducação em Ciências por meio de suas disposições. Embora fundamentais para a pesquisa, osorientadores são pouco estudados e seu trabalho tende a ser visto como individual e artesanal. Faltaminterpretações teóricas que permitam compreender esses processos e apostamos que as disposições,noções propostas por Bernard Lahire, são capazes de contribuir nesse sentido. Analisamos asdisposições de três orientadores neófitos da área de Educação em Ciências, identificamos e discutimosaquelas que se relacionam mais diretamente ao seu trabalho como orientador revelando relações entresuas trajetórias pessoais e acadêmicas e sua atuação como orientadores por meio da análisedisposicional. Dialogamos com a escassa literatura sobre o tema apontando para a originalidade que adisposição promove ao entender a formação para a orientação como fruto de uma trajetória cujo inícioé muito anterior ao ingresso na universidade.
A Capes e a ficha de avaliação da área do Direito
Authors: Tiroli Luiz Gustavo , De Jesus Santos Adriana Regina
Published: April 2023

A formação didático-pedagógica dos professores é um desafio para o ensino jurídico, e para os cursos de bacharelado de modo geral. Por força legal, são os programas de pós-graduação os responsáveis prioritários por essa formação – art. 66, da LDB –. Para atender os critérios da CAPES, o foco maior tem sido a produção científica no campo da pesquisa, e a formação no campo do ensino tem sido preterida. Assim, questiona-se: quais modificações no processo avaliativo da CAPES poderiam contribuir para a formação continuada de professores para o ensino jurídico? Para isso, o objetivo geral consiste em analisar o processo de avaliação dos programas de pós-graduação stricto sensu realizada pela CAPES na consecução de identificar mudanças que pudessem contribuir para o processo de formação continuada de docentes para os cursos jurídicos. O método utilizado é o histórico-indutivo. Adota-se a abordagem qualitativa-quantitativa. A técnica de pesquisa é a revisão bibliográfica e a análise documental. Diante da investigação, constatou-se que modificações pontuais nos critérios avaliativos, no sentido de contemplar estratégias e atividades voltadas a formação docente, poderiam contribuir, ainda que de maneira incipiente, para a construção de espaços de reflexão sobre a necessidade desses conteúdos formativos permearem os cursos de mestrado e doutorado. Respeitando a autonomia científica e acadêmica, a proposta visa possibilitar um espaço de (auto) avaliação no interior dos programas de pós-graduação stricto sensu a respeito da necessidade de promover formação continuada para os professores do ensino jurídico, um problema histórico que precisa ser superado.
N1-Methylnicotinamide: The Mysterious Anti-aging Actor in Renal Transplantation
Authors: Nejabati Hamid Reza , Roshangar Leila
Published: April 2023

The fast global aging of people worldwide is a crucial demographic trend. According to evidence,
Americans aged 65 and above will compose 21.6% of the population by 2040. During the aging process, the
kidney undergoes gradual functional decrease, which turned out to be a forthcoming problem in clinical practice.
Age-related decrease in renal function, evaluated by total glomerular filtration rate (GFR), which has been
shown to drop by approximately 5-10% per decade after the age of 35. The sustaining extended period renal
homeostasis is the main purpose of any therapeutic options intended for delaying or even reversing the aging
kidney. The renal transplant has been regarded as the common alternative for kidney replacement therapy for
elderly patients with end-stage renal disease (ESRD). In the last few years, considerable progress has been
made to find novel therapeutic options for alleviating renal aging, in particular, calorie restriction and pharmacologic
therapy. Nicotinamide N-methyltransferase is an enzyme responsible for generating N1-Methylnicotinamide
(MNAM), notorious for its anti-diabetic, anti-thrombotic, and anti-inflammatory activity. MNAM is
one of the important factors regarded as in vivo probes for evaluating the activity of some renal drug transporters.
Furthermore, it has been shown to have therapeutic potential in the pathogenesis of proximal tubular
cell damage and tubulointerstitial fibrosis. In this article, in addition to addressing the role of MNAM in renal
function, we also explained its anti-aging effects. We conducted an in-depth investigation of the urinary excretion
of MNAM and its metabolites, especially N1-methyl-2-pyridone-5- carboxamide (2py) in RTR. The excretion
of MNAM and its metabolite, 2py, was inversely correlated with the risk of all-cause mortality in renal
transplant recipients (RTR), independent of possible confounders. Therefore, we have shown that the reason for
the lower mortality rate in RTR who had higher urinary excretion of MNAM and 2py may be related to the anti-
aging effects of MNAM through transiently generating low levels of reactive oxygen species, stress resistance
and the activation of antioxidant defense pathways.
Countermeasures for Maintaining Cardiovascular Health in Space Missions
Authors: Kumar Akash , Pramanik Jhilam , Panchal Lakshay , Prajapati Bhupendra
Published: April 2023

During space exploration, the human body is subjected to altered atmospheric environments and gravity, exposure to radiation, sleep disturbance, and mental pressures; all these factors are responsible for cardiovascular diseases. Under microgravity, the physiological changes related to cardiovascular diseases are the cephalic fluid shift, dramatic reduction in central venous pressure, changes in blood rheology and endothelial function, cerebrovascular abnormalities, headaches, optic disc edema, intracranial hypertension, congestion of the jugular vein, facial swelling, and loss of taste. Generally, five countermeasures are used to maintain cardiovascular health (during and after space missions), including shielding, nutritional, medicinal, exercise, and artificial gravity. This article concludes with how to reduce space missions' impact on cardiovascular health with the help of various countermeasures.
Alpha-amylase Inhibitory Activity of Extracts from Algerian Calamintha
nepeta (L.)
Authors: Benabed Khadidja Houda , Boussoussa Hadjer , Khacheba Ihcen , bekhaoua Abir , Douadji Fatima Zohra , Daïdi Sabrina , Djaâfour Souad , Yousfi Mohamed
Published: April 2023

Background::

Calamintha nepeta is a plant from the Lamiaceae family that is known for its traditional use to treat diabetes among Algerian populations. However, till now, there has been no research work to confirm this activity.

Objectives::

This work aimed to evaluate the amylase inhibitory activity of essential oils and phenolic compounds from both methanolic and aqueous extracts of Algerian Calamintha nepeta (L.).

Methods::

The essential oil was obtained by hydrodistillation and analyzed using GC and then GC/MS. Aqueous and methanolic extracts were obtained from the remains of the hydrodistillation. Total phenolic compounds were quantified using the Folin-Ciocalteu method. The amylase inhibitory activity of the extracts was determined by testing their ability to inhibit alpha-amylase.

Results::

The extraction yield was 0.67 % (w/w) for the essential oil, and 11.85 and 4.38 % (w/w) for the aqueous and methanolic extracts, respectively. The essential oil analysis revealed that menthone, menthol, pulegone, and pulegone oxide were the main components of the oil. The total phenolic compounds in the aqueous and methanolic extracts were 41.81 and 32.92 mg GAE/g DW, respectively. The extracts inhibited α-amylase activity with IC50 values of 24.46, 31.54, and 115.47 mg/ml for the methanolic extract, essential oil, and aqueous extract, respectively.

Conclusion::

The different extracts of Calamintha nepeta showed an interesting composition and significant amylase inhibitory activity, emphasizing their successful use in traditional medicine.
In-silico Evaluation of Novel Honokiol Derivatives against Breast Cancer Target
Protein LKB1
Authors: Shahid Izzah , Shoaib Muhammad , Raza Rabail Zehra , Jahangir Muhammad , Abbasi Sumra Wajid , Riasat Areej , Akbar Ansa , Mehnaz Samina
Published: April 2023

Background:

Breast cancer is characterized by uncontrolled cell growth in the breast tissue and is a leading
cause of death globally. Cytotoxic effects and reduced efficacy of currently used therapeutics insist to look for new
chemo-preventive strategies against breast cancer. LKB1 gene has recently been categorized as a tumor suppressor
gene where its inactivation can cause sporadic carcinomas in various tissues. Mutations in the highly conserved LKB1
catalytic domain lead to the loss of function and subsequently elevated expression of pluripotency factors in breast
cancer.

Objectives:

The utilization of drug-likeness filters and molecular simulation has helped evaluate the pharmacological
activity and binding abilities of selected drug candidates to the target proteins in many cancer studies.

Methods:

The current in silico study provides a pharmacoinformatic approach to decipher the potential of novel
honokiol derivatives as therapeutic agents against breast cancer. AutoDock Vina was used for molecular docking of the
molecules. A 100 nano second (ns) molecular dynamics simulation of the lowest energy posture of 3'-formylhonokiol-
LKB1, resulting from docking studies, was carried out using the AMBER 18.

Results:

Among the three honokiol derivatives, ligand-protein binding energy of 3' formylhonokiol with LKB1 protein
was found to be the highest via molecular docking. Moreover, the stability and compactness inferred for 3'-
formylhonokiol with LKB1 are suggestive of 3' formylhonokiol being an effective activator of LKB1 via simulation
studies.

Conclusion:

It was further established that 3'- formylhonokiol displays an excellent profile of distribution, metabolism,
and absorption, indicating it is an anticipated future drug candidate.
Modern Advancements, Patents and Applications of Futuristic
Nanozymes: A Comprehensive Review
Authors: Swain Suryakanta , Ghose Debashish , Jena Bikash Ranjan , Rao GSN Koteswara , Sahu Abhisek
Published: April 2023

In the last few years, nanozymes have emerged as an adequate substitute for natural enzymes.
Recently, much attention has been paid to enzyme-mimic nanomaterials (nanozymes). Because of their
distinct characteristics, they are a critical alternative to natural enzymes that can be produced at a subordinate
cost and more efficiently. These nanomaterials have enzyme-like activity and have been cast off to
detect and treat biomolecules such as DNA, proteins, cells, and tiny molecules such as glucose. Hence,
the critical analysis of recent nanozyme is deemed essential for futuristic research, outcome-based results
specified to current trends of analytical tools, and several disease monitoring for targeted oncology therapies
like circulating tumor cells, MRI, PET, etc. In addition, the multivariate applications of nanozymes
for biosensors, immunoassay formation, tumor cell detection with earlier remedies, and environmentallysound
engineering technologies are discussed to climax the modern advancements. The novelty and originality
of this current review is to intensify the recent advancement, types and mimicking activity, biomedical
applications of nanozymes, implementation of the chemometric approach in nanozymes, and its futuristic
approach. Finally, to promote the understanding of nanozymes and the development of novel and
multifunctional nanozymes, we provide a comprehensive review of the nanozymes with their broadest
applications and modern technologies involved in targeted drug delivery, inventory with other diversified
arenas and existing patents indicating future implications.
L-Proline Catalyzed Organic Reactions via Microwave-Activation
Authors: Karmakar Rajiv , Mukhopadhyay Chhanda
Published: April 2023

In the past few years, using microwave power to heat and wield chemical reactions has be-come a gradually more popular subject in the scientific community. Microwave-supported organic syn-thesis is confirmed to be involved in rapidly synthesizing novel compounds with selectivity and en-hanced biological activities. Microwave flash heating for chemical synthesis is a spectacular reduction in reaction times, high yield and purity of the products, etc. A catalysis field wherein small organic mol-ecules like L-Proline efficiently and selectively catalyzes organic transformations. Microwave-assisted L-Proline catalyzed reactions are valuable tools for making different acyclic, heterocycles, and carbocy-clic scaffolds that signify the main framework of most bioactive compounds. In synthetic organic chem-istry, microwave irradiation speedily discarded the conventional heating methods in the world of multi-component and step-wise synthetic chemistry. This review discusses only L-Proline Catalyzed Organic Reactions under microwave activation using modern organic transformations, including condensation, addition, asymmetric, multi-components, and other modular reactions.
The effects of oral birth control pills (contraceptive pills) intake on lyophilized saliva and its oral manifestations
Authors: Rasheed Rafil Hameed , Faisal Ahmed Rehab
Published: April 2023

A woman is susceptible to oral diseases at various stages in her life span. Besides, multiple biological, behavioral, and social factors affect the general health condition. Many drugs or chemicals can influence the oral cavity & associated structures. An example of these drugs group is oral contraceptive pills (OCS) which women widely use to prevent pregnancy and determine the number of children, and hormonal therapy. This study aims to evaluate the effect of oral contraceptive pills use on salivary secretion and composition in addition to the occurrence of any oral manifestations with the uses of these drugs among women aged 16-45 years. The total number of sample subjects is 51 women. The samples were separated into two groups: The first group included 21 unmarried women with no previous experience with oral contraceptive pills (control group).

In contrast, the second group consisted of 30 women who were married and using this drug (study group). This study is considered to be a comparative study between these two groups concerning the analysis of the salivary composition, unstimulated salivary flow rates and PH level: The results obtained from this study showed a marked significant difference in salivary analysis between the drug user & nonuser drug groups concerning the salivary flow rate while the PH had no statistical differences between them. However, the two groups had a significant difference in alkaline phosphatase enzyme. The salivary analysis showed highly substantial variations in immunoglobulin A (IgA) & total protein levels in saliva between control & study groups; also, in this study, there was a positive association between gingival inflammation with gingival index score (2) (80%), gingival index score (3) (100%) and duration for taking the drug. By this drug administration, the altered salivary flow rate & levels of salivary contents that include (secretary proteins, IgA and enzymes) may influence and play an essential role in oral & dental health.

Keywords: saliva; oral health; oral contraceptive pills.
Impact of licorice and rosemary powder in the diet on several carcass characteristics of local goats
Authors: Al-Shibawi Jinan A.A. , Al-Yaseri Ahmed J. , Al-Dhalimi Hussian M.K. , Al-Gharawi Jassim K.M.
Published: April 2023

A total of 12 male goats were used at the age of four months; the animals were placed in adjacent and separated enclosures. Treatments as follows: T1 (control), T2 adding 5 g/kg of rosemary leaves to powder and T3 adding 5 g/kg of licorice root powder, T4 (the mixture treatment), adding 5 g/kg of rosemary goes to powder and 5 g of licorice root powder. The results showed that the T3 and T4 treatments were significantly superior in live weight, empty body weight, hot and cold carcass weight and the dressing ratio calculated based on empty weight compared to the control treatment. Also, T4 was significantly superior compared to T1 on the total percentages of major cuts. At the same time, there was a significant decrease in the total rates of secondary cuts in treatments T2, T3 and T4 compared to the control treatment T1. The treatments T2, T3 and T4 were significantly superior to the control treatment T1 in the shoulder ratio, while the neck ratio decreased significantly in T3 and T4 compared to the control treatment T1. The control treatment was significantly superior in the ulna segmental ratio compared to T4. Keywords: rosemary, licorice, carcass, local goats.
Influence of humic and fulvic acid addition on soil N P K availability and broad bean output (Vicia Faba L.)
Authors: Mohsen Al- Mughair Hayder Abdul-Hussain , Abbas Al-Waeli Hassan , Hussein Noor Al-jana Mohammed , sihud AL- Hamdawi Esra Rahi
Published: April 2023

A field experiment was carried out during the agricultural season 2021-2022 at Al-Muthanna Governorate to study the effect of adding humic and fulvic acid in the soil on the availability of N P K in the soil, a simple RCBD experiment was designed with three replicates, it included the addition of a mixture of humic and fulvic acid (0, 5, 10 and 15) for L ha-1. The results showed a significant superiority in increasing the concentration of availability NPK in the soil; the H2 treatment gave the highest rate of 204.00 and 32.76 mg kg soil-1 for NK elements, respectively. The H3 treatment also showed the highest increase in the concentration of significant factors availability NPK in the soil after harvest; it reached 28.62, 14.30 and 155.00 mg kg soil-1, respectively. The highest individual yield was 169.00 g plant-1 when treated with H3, compared to the control treatment, which amounted to 134.80 g plant-1.

Keywords: Humic, Fulvic acids, Faba beans, NPK
Effect of adding beetroot (Beta vulgaris rubra) powder and its aqueous extract to growing geese carcasses on carcass quality and measures
Authors: Al-waeli Saad K.J. , H.A. Alasadi Majid , Abbas Rabia J.
Published: April 2023

The present study investigated the influence of supplementing beetroot (Beta vulgaris rubra) powder and its aqueous extract on growing goose's carcass quality and carcass measurements. One hundred eighty one-day-old goslings chicks of Chinese white geese were randomly distributed among five treatment groups containing three replicates of 12 birds each. Five experimental diets were formulated as follows: Control diet without supplementation (T1). T2 and T3, the beetroot extract was supplemented at 15 and 30 (ml/ L) in drinking water; 15, and 30 (g/kg) beetroot powder (T4, T5) in basal diet, respectively. Results indicate that the use of beetroot significantly improved all traits of the studied goose carcass compared to the control treatment, the addition of the aqueous extract at a concentration of 15 ml/ liter of drinking water and beetroot powder at a concentration of 15 g to the feed gave the best results and significantly compared to the rest of the treatments. Keywords: beetroot (Beta vulgaris rubra), carcass quality, carcass measurements, growing goose
The Effect of Monetary Incentives on Health Care Social Media Content: Study Based on Topic Modeling and Sentiment Analysis
Authors: Maleki Negar , Padmanabhan Balaji , Dutta Kaushik
Published: April 2023

Background

While there is high-quality online health information, a lot of recent work has unfortunately highlighted significant issues with the health content on social media platforms (eg, fake news and misinformation), the consequences of which are severe in health care. One solution is to investigate methods that encourage users to post high-quality content.

Objective

Incentives have been shown to work in many domains, but until recently, there was no method to provide financial incentives easily on social media for users to generate high-quality content. This study investigates the following question: What effect does the provision of incentives have on the creation of social media health care content?

Methods

We analyzed 8328 health-related posts from an incentive-based platform (Steemit) and 1682 health-related posts from a traditional platform (Reddit). Using topic modeling and sentiment analysis–based methods in machine learning, we analyzed these posts across the following 3 dimensions: (1) emotion and language style using the IBM Watson Tone Analyzer service, (2) topic similarity and difference from contrastive topic modeling, and (3) the extent to which posts resemble clickbait. We also conducted a survey using 276 Amazon Mechanical Turk (MTurk) users and asked them to score the quality of Steemit and Reddit posts.

Results

Using the Watson Tone Analyzer in a sample of 2000 posts from Steemit and Reddit, we found that more than double the number of Steemit posts had a confident language style compared with Reddit posts (77 vs 30). Moreover, 50% more Steemit posts had analytical content and 33% less Steemit posts had a tentative language style compared with Reddit posts (619 vs 430 and 416 vs 627, respectively). Furthermore, more than double the number of Steemit posts were considered joyful compared with Reddit posts (435 vs 200), whereas negative posts (eg, sadness, fear, and anger) were 33% less on Steemit than on Reddit (384 vs 569). Contrastive topic discovery showed that only 20% (2/10) of topics were common, and Steemit had more unique topics than Reddit (5 vs 3). Qualitatively, Steemit topics were more informational, while Reddit topics involved discussions, which may explain some of the quantitative differences. Manual labeling marked more Steemit headlines as clickbait than Reddit headlines (66 vs 26), and machine learning model labeling consistently identified a higher percentage of Steemit headlines as clickbait than Reddit headlines. In the survey, MTurk users said that at least 57% of Steemit posts had better quality than Reddit posts, and they were at least 52% more likely to like and comment on Steemit posts than Reddit posts.

Conclusions

It is becoming increasingly important to ensure high-quality health content on social media; therefore, incentive-based social media could be important in the design of next-generation social platforms for health information.
The Past, Present, and Future of Psychotherapy Manuals: Protocol for a Scoping Review (Preprint)
Authors: Wislocki Katherine , Tran Mai-Lan , Petti Emily , Hernandez-Ramos Rosa , Cenkner David , Bridgwater Miranda , Naderi Ghazal , Walker Leslie , Zalta Alyson K
Published: April 2023

BACKGROUND

Psychotherapy manuals are critical to the dissemination of psychotherapy treatments. Psychotherapy manuals typically serve several purposes, including, but not limited to, establishing new psychotherapy treatments, training providers, disseminating treatments to those who deliver them, and providing guidelines to deliver treatments with fidelity. Yet, the proliferation of psychotherapy manuals has not been well-understood, and no work has aimed to assess or review the existing landscape of psychotherapy manuals. Little is known about the breadth, scope, and foci of extant psychotherapy manuals.

OBJECTIVE

This scoping review aims to identify and explore the landscape of existing book-based psychotherapy manuals. This review aims to specify the defining characteristics (ie, foci, clinical populations, clinical targets, treatment type, treatment modality, and adaptations) of existing book-based psychotherapy manuals. Further, this review will demonstrate how this information, and psychotherapy manuals more broadly, has changed over time. This project aims to make a novel contribution that will have critical implications for current methods of developing, aggregating, synthesizing, and translating knowledge about psychotherapeutic treatments.

METHODS

This scoping review will review book-based psychotherapy manuals published from 1950 to 2022.This scoping review will be informed by guidance from the Joanna Briggs Institute Scoping Review Methodology Group and prior scoping reviews. Traditional search and application programming interface–based search methods will be used with search terms defined a priori to identify relevant results using 3 large book databases: Google Books, WorldCat, and PsycINFO. This review will leverage machine learning methods to enhance and expedite the screening process. Primary screening of results will be conducted by at least 2 authors. Data will be extracted and double-coded by research assistants using an iteratively defined codebook.

RESULTS

The search process produced 78,600 results, which were then iteratively deduplicated. Following deduplication, 50,583 results remained. The scoping review is expected to identify common elements of psychotherapy manuals, establish how the foci and content of manuals have changed over time, and illustrate coverage and gaps in the landscape of psychotherapy manuals. Results from this scoping review will be critical for future work focused on developing, aggregating, synthesizing, and disseminating knowledge about psychotherapeutic treatments.

CONCLUSIONS

This review will provide knowledge about the vast landscape of psychotherapy manuals that exist. Findings from this study will inform future efforts to develop, aggregate, synthesize, and translate knowledge about psychotherapeutic treatments.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/47708
Development of Bacterial Cocktail of Strains Staphylococcus hominis, Staphylococcus warneri, Bacillus subtilis, and Micrococcus luteus as active ingredients for Skin Care Formula
Authors: Fathan Luthfi Hawari  , Tesya Almadea  , Karina Hananingsih  , Ahmad Baikuni  , Amarila Malik  , Arifianti Ayun Erwina , Ramadon Delly , Tjampakasari Conny Riana
Published: April 2023

The microbial-based skin health care products that balance one's skin microbiome mimicking healthy skin are rapidly growing. Postbiotics gain more advantages in safety, shelf life, active peptides, and other active compounds such as GABA, which benefit human skin. We have isolated skin commensal bacteria, i.e., Staphylococcus hominis MBF12-19J, Staphylococcus warneri MBF02-19J, Micrococcus luteus MBF05-19J and Bacillus subtilis MBF10-19J in our previous study. This study aimed to make a formula of bacterial cocktail (BC) of those strains, elevate the BC formula into a ferment lysate (FL), and characterize the activities and test for skin sensitivity. The antibacterial activity was done by conducting a competition test using Propionibacterium acnes as an indicator bacterium, whereas the antioxidant activity assay was carried out using the DPPH method. The skin sensitivity was tested using the patch test method. The BC was lyzed by optimizing the enzymatic and ultrasonication methods, whereas sucrose was added as lyoprotectant to obtain a stable powder FL. Potential activity to inhibit P. acnes growth was achieved by a formula of FL consisting of M. luteus MBF05-19J: B. subtilis MBF10-19J: S. warneri MBF02-19J: S. hominis MBF12-19J in a ratio 1.5:1.5:0.5:0.5 or equivalent to DNA copy number/mL 1.01E+16: 1.14E+24: 1.96E+22: 1.50E+18. Skin sensitivity test results showed no sensitivity reaction, guaranteeing that CFS and FL are safe to use for the skin. Sucrose-FL at 12% sucrose formula showed higher physical stability than those without. However, the result of potential antioxidants showed mild and very mild activities compared to standard ascorbic acid.
Steroidal Saponin Isolated from Dioscorea alata L. Extract Improve Digestive Tract Allergy in Balb/C Mice Induced by Ovalbumin
Authors: Makiyah Sri Nabawiyati Nurul , Tasminatun Sri , Djati Muhammad Sasmito , Rifa’i Muhaimin , Widodo Widodo
Published: April 2023

Steroidal saponin compound in Dioscorea species is one of the crucial substance because it has some biological functions, such as immunomodulatory and anti-allergic agent. This study aims to analyze the effect of steroidal saponin of Dioscorea alata L. on CD4 T cells activation, cytokines IL-4, IL-5 and TGF-β. This study used primary lymphocyte cell which isolated from BALB/c mice spleen. Mice lymphocyte were cultured in the complete medium with presence of various concentrations (50, 25 and 12.5 µg/mL) of three isolate of steroidal saponin of D. alata for 24 h. Diosgenin was used as positive control. After 24 h of treatment, the activation of lymphocyte, IL-4 and IL-5 production was determined by Flowcytometry analysis. Data were analyzed using student t-test with p < 0.05 and p < 0.01. The results showed that the low concentration of Isolate 1 (12.5 µg/mL) was found to be effective to stimulate the activation of CD4 T cells, reduce the production of IL4 and IL-5 by CD4 T cells and increase TGF-β production. These results showed that a low concentration of steroidal saponin of D. alata could be considered as immunomodulatory and anti-allergic agent. Purification and identification of each isolate isolated from DAE is in progress.
Efficacy of Different Solvents in the Extraction of Bioactive Compounds and Anticancer Activities of Thyme (Thymus vulgaris L.) Leaves and Twigs
Authors: Kamalia Aify Zulfa , Tunjung Woro Anindito Sri
Published: April 2023

Thyme contains phytochemicals that exhibit cytotoxic and cytogenic activities. Differ solvents have different abilities in dissolving plant bioactive compounds. The objective of this study is to determine the anticancer properties of thyme leaves and twigs including profile of bioactive compounds, cytotoxicity, ability of apoptosis induction and caspase-3 activation of different solvent extracts on T47D breast cancer cell line. An experimental study was conducted in eight groups. T47D breast cancer cell line was treated with thyme extracts as treatment group, doxorubicin as positive control, while untreated T47D cells were used as negative control. Thyme was extracted by maceration using 6 different solvents: methanol, ethanol, chloroform, ethyl acetate, dichloromethane, and n-hexane. Bioactive compounds of all extracts were analyzed by GC-MS. Cytotoxicity was investigated through MTT assay on T47D breast cancer cell line. The percentage of apoptosis and caspase-3 were detected by flow cytometry using Annexin V-PI and BD Cytofix/Cytoperm, respectively. Thymol as the main bioactive compound in thyme was found in all extracts. MTT results revealed that six solvents extracts had moderate to weak cytotoxicity with dichloromethane had the lowest IC50 values at 120.23 µg/ml. All thyme extracts promoted apoptosis in T47D cells with apoptosis percentage of methanol, chloroform, ethyl acetate, ethanol, dichlorometane, n-Hexane and doxorubicin were 82.67; 80.98; 73.13; 72.28; 60.62; 27.74 and 98.43%, respectively. Among all extracts, methanol extract showed the highest apoptosis and caspase-3 activation percentage. We conclude that all thyme extracts had anticancer properties in T47D breast cancer cell line although efficacy of each solvent extract was differed.
Aging vs Development in Asia A Sociological Appraisal
Authors: Sheykhi Mohammad Taghi
Published: April 2023

Aging is widely affected by development with special reference to Asia. This part of the world has been changing quite fast in the 50 years. If we look at East Asia, it has drastically changed. Education has played a large part ___ bringing about change in other sectors. Aging was highly promoted in Asia because of access to industries, medical technology and many more. Moreover, many young women have avoided having children in time which has widely helped in the expansion of the elderly people in various parts of Asia. The phenomenon has transformed to a social, economic and cultural issue for the continent. It is even predicted that in the years to come, the number of aging people will be far more than active people.
Exam Questions from Essay to MCQ with Different Levels of Difficulty in Engineering Mechanics
Authors: Ata Atef , Ghazy Mohammed
Published: April 2023

In this paper some techniques to avoid students’ guessing of the correct answer in MCQ exams are proposed. An example from engineering mechanics course is introduced with different levels of difficulty. Random and adaptive selections of choices are introduced according to the physics and difficulty of the problem. The proposed techniques proved to be efficient in reducing guessing of correct answers based on partial or no knowledge of the subject matter. Also, a proposal of establishing online exam using pools of MCQ’s with different levels of difficulty is introduced. Five basic types of exams with different number of questions based on instructors’ desire are tabulated.
Innovating Formative Assessment to improvise Learner Engagement amongst Second Language Learners in light of NEP 2020
Authors: Mangala Mahesh Madhav Deshmukh , Manju Lalita Ghanshyam Mutreja
Published: April 2023

National Education Policy 2020, Para 12.2 states, ‘’Accordingly, curriculum and pedagogy will be designed by institutions and motivated faculty to ensure a stimulating and engaging learning experience for all students, and continuous formative assessment will be used to further the goals of each programme. All assessment systems shall also be decided by the HEI, including those that lead to final certification.” The core of the NEP 2020, rests in holistic development of learners while working on the principles of Universal Design for Learning and not, ‘One Size Fits All” paradigm. Understanding the thin lines of the policy, the Act points out in differentiating measurement, assessment and evaluation of a learner in the hands of Teacher and not the Administrators or Affiliating Bodies. The Assessment formats need to provide for Multiple Means of Representation, Flexibility and Autonomy to learners and not just Assessment of learning, as we are doing it presently. They need to be bi-directional where it not only assesses the learner’s abilities but also provides input to the teacher in designing its pedagogy. This article aims at demonstrating ways of assessing students innovatively in the consortium of English Language with an aim to upsurge the thinking process of a teacher in the designing continuous assessment process suiting its needs.
Theoretical Representation of Ecocriticism in Dhruv P Bhatt’s Oceanside Blues
Authors: B Soni Rima , G Rao Dr. Vidya
Published: April 2023

Dhruv P Bhatt, who is excellent in Gujarati language and literature, is one of the foremost pioneers of impudent ecocritical issues in narratives in Gujarati literature. Contemporary accomplishments of Gujarati literature are depicted in Bhatt’s Samudrantike, written in the Gujarati language in the foundation stage. Subsequently, the text was translated into English as Oceanside Blues by Vinod Meghani in 2013. The focus of the novel offered is set against the background of his own experience. The present paper titled, “Theoretical Representation of Dhruv P Bhatt’s Oceanside Blues seems to explore the theory of ecocriticism, environmental problems, importance of coastal area of Gujarat, sea, festivities related to Gujarati Khaarava’ as well as culture and taboos of Guajarati maritime community with the variegated characteristics.
Wireless Phone Cover Charger Using Solar Energy
Authors: Tiwari Yash , Amaan Mohd , Kumar Vikas , Gupta Rini , Porwal Shivam
Published: April 2023

Abstract: In this paper, completely different geometrics of a solar battery associated coil are realized by analyzing its practicality to get an optimum wireless phone cover charger. Wireless charging could be a terribly broader space of analysis and an amazing quantity of analysis is already been exhausted. However during this paper, we've got tried enquiring the choice approach for charging wirelessly that's charging through solar battery and coil by fixing it during a approach in order that it result for constant
Setting the Tone for Sound Forensic Investigations on Android-Based Social Media Platforms
Authors: Makate Austin , Muduva Martin , Chaudhary Naveen Kumar , Chiwariro Ronald
Published: April 2023

Abstract: Android Social Media Applications have become a yardstick in facilitating a platform for human socialization on cyber space. They are an inevitable alternative, which is fast replacing most traditional ways that lacks full multimedia interaction adored by many. These applications are of forensic value as they account for most activities helpful in either incriminating or exonerating suspects in cases of adverse events. By default, most social applications store activity data in specific directories they create at the background of the hosting Android devices. Through expertise, this data can be extracted and analyzed to come up with meaningful insights useful in an inquiry of digital evidence interest. This study focused on forensics of Twitter and Clubhouse android based social media applications. The approach taken was to install these applications on emerging Android devices using the Samsung Galaxy S20+ (SMGS20+) and Samsung Galaxy Tab A7 (SMGTA7), populate known test data, perform data acquisition, execute data analysis noting results and then do a comparative analysis of tools and techniques utilized towards provisioning alternative solutions.
“And We are Reading Aphorisms from Wilde while Sitting on the Sand...”: Poetics of Aphorism and Paradox in the Works of I. Severyanin
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kuznetsova Ekaterina V.
Published: April 2023

The article examines the influence of the English writer Oscar Wilde on the formation of ironic-paradoxical style and genre of aphoristic statements in the works of the Russian poet Igor Severyanin. Wilde’s popularity in Russia in the 1900–1910s was so great that his public image, demeanor and literary style became an object of imitation and creative reinterpretation among the artistic intelligentsia. The English dandy played a particularly prominent role in the formation of the stage image and literary poetics of Severyanin, whom his contemporaries called “the Russian Wilde”. And although the poet himself denied the Wilde’s influence, a comparative analysis shows numerous thematic echoes of the aphorisms of the English writer in Severyanin’s aphorisms. Veiled maxims and paradoxical statements in some of his poems are also present due to the influence of that special language, which Wilde had created. The ironic and ambiguous style of Severyanin was formed as a result of his attempts to master a specific style, which has its roots in the works of the English aesthete. However, this influence was not solely direct. The very contradictory image of Wilde, that of a suffering ironist, was formed in the works of Severyanin largely under the influence of critical articles by K. Chukovskiy.
O. Wilde in N.S. Gumilev’s Life and Work
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Filatov Anton V. ,   Lomonosov Moscow State University
Published: April 2023

The article considers the influence of O. Wilde’s personality and works on N.S. Gumilev’s strategy of self-presentation, as well as on his artistic and journalistic texts. The hypothesis is put forward that the Russian poet in his youth consciously focused on Wilde’s and his characters’ behavior model, constructing the image of a dandy in an effort to compensate for his unattractive appearance. This strategy remained relevant for Gumilev until the end of his life, as indicated by the memoirs of contemporaries, who preserved the image of the poet, who wore an exotic deer dokha with a fur hat in post-revolutionary Petrograd in 1918–1921, as well as a London tailcoat. Interest in the lifestyle and manners of the Anglo-Irish writer was reinforced by Gumilev’s close attention to his work. This is evidenced by reminiscences and quotations from Wilde’s poems, critical essays, as well as his novel “The Picture of Dorian Gray” and the play “Salome”, which the novice poet uses in his letters to V.Ya. Bryusov and V. Arens, his own poems, and later in critical and literary reviews and papers. At the end of the article, it is suggested that the essay “The Decay of Lying” is one of the sources of Gumilev’s article “On Verhaeren” (1908), as well as of his fairy-tale poem “Northern Raja” (1908).
O. Wilde in the Critical Understanding of K. Chukovsky: History and Evolution
Authors:   Branch of the Military Academy of Logistics named after General of the Army A.V. Khrulev, Morozova Svetlana N. , Kuznetsova Ekaterina V. ,   А.М. Gorky Institute of World Literature of the Russian Academy of Sciences
Published: April 2023

The article is devoted to the analysis of the peculiarities of K.I. Chukovsky’s reception of O. Wilde’s works. It is noted that the attitude to the English writer was adjusted by the critic and evolved throughout his literary activity and was largely determined by the changing historical and cultural context in Russia. This trend can be traced both in the general tone of the writer’s critical works dedicated to Wilde, as well as in Chukovsky’s individual diary entries and his epistolary. In the course of the study, it was found that Chukovsky’s early reception of Wilde is characterized by harsh criticism and the rejection of his eccentric tendencies, which later in the 1960s Chukovsky perceived as a way to fight Puritan morality of the bourgeois. In addition, it was Chukovsky who actively created the image of “suffering Wilde” during the 1910s, which became a part of the “Russian” Wilde myth. It was determined that the research of foreign authors and one of the letters of M. Gorky contributed to the change in the attitude of Chukovsky to Wilde.
ascensão da direita radical no Leste Europeu e a perseguição aos direitos LGBTQIA+
Authors: De Araújo Gomes Maiko Jhonata , Lira de Menezes Lucas
Published: April 2023

O presente artigo visa evidenciar a relação entre a ascensão da direita radical no Leste Europeu, a partir da década de 1990 e o descumprimento de direitos LGBTQIA+ na Hungria (2012-2022) e Polônia (2015-2022). Ademais, fazendo uso da metodologia qualitativa explicativa, vinculada à ferramenta analítica de estudo comparativo, tem-se como objetivos específicos: (I) expor os principais eventos a nível doméstico e internacional diretamente relacionados à ascensão da direita radical na região; (II) destacar as similaridades e diferenças acerca das narrativas envolvendo os direitos LGBTQIA+ nos dois países; (III) evidenciar as respostas internacionais para com essas infrações de direitos. Assim, a pergunta-problema caracteriza-se como: por que a direita radical do Leste Europeu passou a adotar com tanta veemência a perseguição aos direitos da população LGBTQIA+ como parte de suas agendas políticas no século XXI? Portanto, a hipótese é que a transnacionalização da luta LGBTQIA+ é compreendida por alguns segmentos da Sociedade Internacional enquanto uma forma de imposição ideológica do Ocidente e, por isso, deve ser combatida em defesa da cultura e valores locais.
Sistema mundial com características chinesas:
Authors: Gualberto do Nascimento Lucas
Published: April 2023

No atual século, com a ascensão chinesa e a sua crescente participação na economia e no sistema político mundial, há o desenvolvimento de uma influente perspectiva chinesa das relações internacionais. Nas últimas quatro décadas, movimentos da intelectualidade chinesa promoveram o surgimento de visões próprias, nacionais, do sistema mundial. Este artigo destaca três vertentes da filosofia política chinesa para o sistema internacional: o Tudo Sob o Céu (Tianxia), a dialética Zhongyong e o Realismo Moral como elementos teóricos formuladores de uma perspectiva de sistema mundial com características chinesas. O objetivo, portanto, é analisar, a partir do seu processo histórico de ascensão, como estas correntes de pensamento para uma ordem internacional são resultado da formação social e do Estado chinês, e como estas diferenciam-se das tradições da filosofia política ocidental e suas bases epistemológicas. Estas vertentes se projetam em termos de ideias e instituições para uma perspectiva chinesa de ordem internacional no século XXI.
La CELAC y la Alianza del Pacífico en la diversificación de las relaciones económicas internacionales de México (2009-2019)
Authors: Franzoni Marcela , Carvalho Carlos Eduardo
Published: April 2023

El artículo cuestiona las posibilidades de diversificación del comercio exterior de México a través de iniciativas diplomáticas amplias hacia América Latina, frecuentemente señalada como un contrapeso al rol histórico de los Estados Unidos. Para eso, analisa los resultados de la participación mexicana en la Comunidad de Estados Latinoamericanos y Caribeños (CELAC) y en la Alianza del Pacífico (AP) en términos de diversificación del origen y destino de sus exportaciones e importaciones entre los años 2009-2019. A partir del análisis de documentos y estadísticas oficiales de México y de la revisión de literatura, debatimos la hipótesis de que la participación de México en estas iniciativas no resultó en diversificación del comercio exterior hacia América Latina y el Caribe pues el comercio intrarregional disminuyó en el período. Los datos muestran que la región se volvió menos representativa en el comercio exterior de México, que se mantuvo concentrado en Estados Unidos. Se concluye que la participación de México en estas dos iniciativas comprueba que la diversificación comercial no es posible con iniciativas amplias y generales. La diversificación apareció como discurso retórico, posiblemente para atender a los objetivos de legitimación de la política interna, sin estrategias ni planes concretos para lograrla.
CLA + memory T cells in atopic dermatitis
Authors: Santamaria-Babí Luis , Nicolàs Lídia Sans-de San , Czarnowicki Tali , Akdis Mübeccel , Pujol Ramon Maria , Lozano-Ojalvo Daniel , Leung Donald , Guttman-Yassky Emma
Published: April 2023

CLA memory T cells constitute a small subset of
human memory T cells. Circulating skin-homing T cells participate in
several aspects of atopic dermatitis, such as Staphylococcus
aureus involvement in inflammation, the abnormal Th2 immune response,
biomarkers, clinical aspects of the patients, pruritus, and the
mechanism of action of targeted therapies. Superantigens, IL-13, IL-31,
pruritus, CCL17 and early effects on dupilumab-treated patients have in
common that they are related to CLA T cell response
in patients. The function of CLA T cells is closely
related to the role of T cells belonging to the skin-associated lymphoid
tissue and could be a reason why they reflect different mechanisms of
atopic dermatitis. The goal of this review is to gather all this
translational information of atopic dermatitis pathology.