bluuebunny/crossref_metadata_2025 huggingface dataset:
A meta-analysis of Early Results to predict Vaccine efficacy against Omicron
Authors: Khoury David S. , Steain Megan , Triccas James A. , Sigal Alex , Davenport Miles P. , Cromer Deborah
Published: December 2021

In the studies to date, the estimated fold-drop in neutralisation titre against Omicron ranges from 2- to over 20-fold depending on the study and serum tested. Collating data from the first four of these studies results in a combined estimate of the drop in neutralisation titre against Omicron of 9.7-fold (95% CI 5.5-17.1). We use our previously established model to predict that six months after primary immunisation with an mRNA vaccine, efficacy for Omicron is estimated to have waned to around 40% against symptomatic and 80% against severe disease. A booster dose with an existing mRNA vaccine (even though it targets the ancestral spike) has the potential to raise efficacy for Omicron to 86.2% (95% CI: 72.6-94) against symptomatic infection and 98.2% (95% CI: 90.2-99.7) against severe infection.
Brain injury environment critically influences the connectivity of transplanted neurons
Authors: Grade S. , Thomas J. , Zarb Y. , Thorwirth M. , Conzelmann Karl-Klaus , Hauck Stefanie M. , Götz Magdalena
Published: December 2021

Cell transplantation is a promising approach for the reconstruction of neuronal circuits after brain damage. Transplanted neurons integrate with remarkable specificity into circuitries of the mouse cerebral cortex affected by neuronal ablation. However, it remains unclear how neurons perform in a local environment undergoing reactive gliosis, inflammation, macrophage infiltration and scar formation, as in traumatic brain injury (TBI). To elucidate this, we transplanted cells from the embryonic mouse cerebral cortex into TBI-injured, inflamed-only, or intact cortex of adult mice. Brain-wide quantitative connectomics unraveled graft inputs from correct regions across the brain in all conditions, with pronounced quantitative differences: scarce in intact and inflamed brain, versus exuberant after trauma. In the latter, excessive synapse pruning follows the initial overshoot of connectivity resulting in only a few connections left. Proteomic profiling identifies candidate molecules involved in the synaptic yield, a pivotal parameter to tailor for functional restoration of neuronal circuits.

Teaser

Neuronal grafts in a brain area affected by trauma receive excessive yet mostly vulnerable inputs from host circuits.
Structure and dynamics of human disease-complication network
Authors: Jiang Xiong-Fei , Xiong Long , Bai Ling , Lin Jie , Zhang Jing-Feng , Yan Kun , Zhu Jia-Zhen , Zheng Bo , Zheng Jian-Jun
Published: December 2021

A complication is an unanticipated disease arisen following, induced by a disease, a treatment or a procedure. We compile the Human Disease-Complication Network from the medical data and investigate the characteristics of the network. It is observed that the modules of the network are dominated by the classes of diseases. The relations between modules are unveiled in detail. Three nontrivial motifs are identified from the network. We further simulate the dynamics of motifs with the Boolean dynamic model. Each motif represents a specific dynamic behavior, which is potentially functional in the disease system, such as generating temporal progressions and governing the responses to fluctuating external stimuli.

Author summary

Advances in molecular biology lead to a new discipline of network medicine, investigating human diseases in a networked structure perspective. Recently, clinical records have been introduced to the research of complex networks of diseases. An important available medical dataset that has been overlooked so far is the complications of diseases, which are vital for human beings. We compile the Human Disease-Complication Network, representing the causality between the upstream diseases and their downstream complications. This work not only helps us to comprehend why certain groups of diseases appear collectively, but also provides a new paradigm to investigate the dynamics of disease progression. For clinical applications, the investigation of complications may yield new approaches to disease prevention, diagnosis and treatment.
An amphipathic and cationic antimicrobial peptide kills colistin resistant Gram-negative pathogens in vivo
Authors: Thomsen Thomas T. , Kolpen Mette , Wigneswaran Vinoth , Kromann Ulrik , Ebbensgaard Anna E. , Hammerum Anette M. , Hasman Henrik , Radmer Stine , Kragh Kasper N. , Hartmann-Petersen Rasmus , Hansen Paul Robert , Folkesson Anders , Frimodt-Møller Niels , Løbner-Olesen Anders
Published: December 2021

New antibiotics are needed against multidrug resistant Gram-negative pathogens that have compromised global health systems. Antimicrobial peptides are generally considered promising lead candidates for the next generation of antibiotics but have not fulfilled this expectation. Here we demonstrate activity of a cationic amphipathic undecapeptide (ChIP; Charge change Independent Peptide) against a wide panel of multidrug resistant Gram-negative pathogens. Importantly, the antimicrobial activity of ChIP is independent of the surface charge changes that confer colistin resistance through modification of Lipid A, while decreased activity of ChIP correlates with GlcN1 tri-acylation of Lipid A. In an in vivo peritonitis mouse model ChIP displays excellent activity against both colistin sensitive and resistant Escherichia coli and Acinetobacter baumannii strains.

Author Summary

Antimicrobial peptides hold promise as novel treatment options for diseases caused by multidrug resistant bacteria. Here we present evidence that the ChIP peptide, comprised of 11 D-amino acids, is active against a variety of Gram-negative bacteria that ranks high on the WHO list of critically important pathogens. ChIP initially interacts with the Gram-negative outer membrane, independent of its surface charge, followed by entry into the periplasm and permeabilization of the inner membrane, leading to bacterial cell death. Detailed analyses of the outer membrane indicate that the acylation pattern of lipopolysaccharides plays an important role for ChIP activity. In a mouse infection model, ChIP display excellent activity in reducing bacterial numbers for both Escherichia coli and Acinetobacter baumannii. Importantly, ChIP is highly efficient against bacteria resistant to colistin, an antibiotic normally considered as a last resort treatment of infections caused by multidrug resistant Gram-negative bacteria.
Seasonal resistome diversity and dissemination of WHO priority antibiotic-resistant pathogens in Lebanese estuaries
Authors: Hobeika Wadad , Gaschet Margaux , Ploy Marie-Cécile , Buelow Elena , Sarkis Dolla Karam , Dagot Christophe
Published: December 2021

Anthropogenic activities are demonstrated to be the key drivers of antimicrobial resistance (AMR) dissemination in the environment. Lebanese rivers that lead to the Mediterranean Sea were sampled at estuaries’ sites, under high anthropogenic pressure, in spring 2017 and winter 2018 to study seasonal variation of antimicrobial-resistant bacteria (ARBs) and antimicrobial resistance genes (ARGs). Methods: A combined approach using culture techniques and high throughput qPCR identified hotspots for antimicrobial resistance and anthropogenic pressure in particular locations along the Lebanese coast. Results: Multi-resistant Gram-negative (Enterobacterales and Pseudomonas spp) and Gram-positive bacterial pathogens were isolated. A high abundance of certain ARGs (vanB, blaBIC-1, blaGES, tetM, and mcr-1) was detected in 5 Lebanese estuaries. The relative abundance of ARGs was highest in winter and areas with high anthropogenic activities and population growth with an influx of refugees. Conclusion: Qualitative analysis of ARB and the analysis of the Lebanese estuaries’ resistome revealed critical levels of contamination with pathogenic bacteria and provided significant information about the spread of ARGs in anthropogenically impacted estuaries.
Single-molecule sizing through nano-cavity confinement
Authors: Jacquat Raphaël P. B. , Krainer Georg , Peter Quentin A. E. , Babar Ali Nawaz , Vanderpoorten Oliver , Xu Catherine K. , Welsh Timothy J. , Kaminski Clemens F. , Keyser Ulrich F. , Baumberg Jeremy J. , Knowles Tuomas P. J.
Published: December 2021

An approach relying on nano-cavity confinement is developed in this paper for the sizing of nanoscale particles and single biomolecules in solution. The approach, termed nano-cavity diffusional sizing (NDS), measures particle residence times within fluidic nano-cavities to determine their hydrodynamic radii. Using theoretical modeling and simulation, we show that the residence time of particles within nano-cavities above a critical timescale depends on the diffusion coefficient of the particle, which allows estimation of the particle’s size. We demonstrate this approach experimentally through measurement of particle residence times within nano-fluidic cavities using single-molecule confocal microscopy. Our data show that the residence times scale linearly with the sizes of nanoscale colloids, protein aggregates and single DNA oligonucleotides. NDS thus constitutes a new single molecule optofluidic approach that allows rapid and quantitative sizing of nanoscale particles for potential application in nanobiotechnology, biophysics, and clinical diagnostics.

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Characterizing the Behavioral and Neuroendocrine Features of Susceptibility and Resilience to Social Stress
Authors: Murra Dalia , Hilde Kathryn L. , Fitzpatrick Anne , Maras Pamela M. , Watson Stanley J. , Akil Huda
Published: December 2021

Evaluating and coping with stressful social events as they unfold is a critical strategy in overcoming them without long-lasting detrimental effects. Individuals display a wide range of responses to stress, which can manifest in a variety of outcomes for the brain as well as subsequent behavior. Chronic Social Defeat Stress (CSDS) in mice has been widely used to model individual variation following a social stressor. Following a course of repeated intermittent psychological and physical stress, mice diverge into separate populations of social reactivity: resilient (socially interactive) and susceptible (socially avoidant) animals. A rich body of work reveals distinct neurobiological and behavioral consequences of this experience that map onto the resilient and susceptible groups. However, the range of factors that emerge over the course of defeat have not been fully described. Therefore, in the current study, we focused on characterizing behavioral, physiological, and neuroendocrine profiles of mice in three separate phases: before, during, and following CSDS. We found that following CSDS, traditional read-outs of anxiety-like and depression-like behaviors do not map on to the resilient and susceptible groups. By contrast, behavioral coping strategies used during the initial social stress encounter better predict which mice will eventually become resilient or susceptible. In particular, mice that will emerge as susceptible display greater escape behavior on Day 1 of social defeat than those that will emerge as resilient, indicating early differences in coping mechanisms used between the two groups. We further show that the social avoidance phenotype in susceptible mice is specific to the aggressor strain and does not generalize to conspecifics or other strains, indicating that there may be features of threat discrimination that are specific to the susceptible mice. Our findings suggest that there are costs and benefits to both the resilient and susceptible outcomes, reflected in their ability to cope and adapt to the social stressor.
Effects of active and passive enrichment regimes on fecal glucocorticoid metabolite levels in captive Indian leopards (Panthera pardus fusca)
Authors: Panchal Nirali , Desai Chena , Ghosal Ratna
Published: December 2021

Environmental enrichment improves health and wellbeing of zoo animals. To test this hypothesis, we used Indian leopards, one of the popular zoo animals, as a model system to understand effects of active (interacting) and passive (noninteracting) enrichment elements on stress hormone levels of captive individuals. We included three enrichment categories, category ‘A’ (having both active: large size cage, and passive: controlled temperature, playback of forest sounds and sound proof glasses to filter visitors’ noise, enrichment elements), category ‘B’ (active enrichment type I, small size cage with air coolers), and category C (active enrichment type II, medium size cage without air coolers) for the leopards (n=14) housed in two Indian zoos. We standardized a non-invasive method to measure fecal glucocorticoid metabolite (fGCM) levels in captive leopards. The standardized fGCM assay was further validated by analysing samples from free-ranging leopards, as well. The fGCM levels (Mean±SE) were 10.45±2.01 and 0.95±0.003μg/g dry wt of feces in captive and free-ranging leopards, respectively. Our results demonstrated that fGCM levels of leopards in categories B and C were significantly (P<0.05) different from each other, thus, indicating cage size (an active enrichment element) as an important factor in influencing the physiology of the sampled animals. Overall, the findings of the study will contribute towards informing policies for management of the Indian leopards.
Pose-gait analysis for cetaceans with biologging tags
Authors: Zhang Ding , Goodbar Kari , West Nicole , Lesage Veronique , Parks Susan , Wiley Dave , Barton Kira , Shorter K. Alex
Published: December 2021

Biologging tags are a key enabling tool for investigating cetacean behavior and locomotion in their natural habitat. Identifying and then parameterizing gait from movement sensor data is critical for these investigations. But how best to characterize gait from tag data remains an open question. Further, the location and orientation of the tag on an animal in the field are variable and can change multiple times during deployment. As a result, the relative orientation of the tag with respect to (wrt) the animal must be determined before a wide variety of further analyses. Currently, custom scripts that involve specific manual heuristics methods tend to be used in the literature. These methods require a level of knowledge and experience that can affect the reliability and repeatability of the analysis. The authors of this work argue that an animal’s gait is composed of a sequence of body poses observed by the tag, demonstrating a specific spatial pattern in the data that can be utilized for different purposes. This work presents an automated data processing pipeline (and software) that takes advantage of the common characteristics of pose and gait of the animal to 1) Identify time instances associated with occurrences of relative motion between the tag and animal; 2) Identify the relative orientation of tag wrt the animal’s body for a given data segment; and 3) Extract gait parameters that are invariant to pose and tag orientation. The authors included biologging tag data from bottlenose dolphins, humpback whales, and beluga whales in this work to validate and demonstrate the approach. Results show that the average relative orientation error of the tag wrt the dolphin’s body after processing was within 11 degrees in roll, pitch, and yaw directions. The average precision and recall for identifying relative tag motion were 0.87 and 0.89, respectively. Examples of the resulting pose and gait analysis demonstrate the potential of this approach to enhance studies that use tag data to investigate movement and behavior. MATLAB source code and data presented in the paper were made available to the public (https://github.com/ding-z/cetacean-pose-gait-analysis.git), with suggestions related to tag data processing practices provided in this paper. The proposed analysis approach will facilitate the use of biologging tags to study cetacean locomotion and behavior.
Characterization of metabolic compartmentalization in the liver using spatially resolved metabolomics
Authors: van der Reest Jiska , Stopka Sylwia A. , Abdelmoula Walid M. , Ruiz Daniela F. , Joshi Shakchhi , Ringel Alison E. , Haigis Marcia C. , Agar Nathalie Y. R.
Published: December 2021

Cells adapt their metabolism to physiological stimuli, and metabolic heterogeneity exists between cell types, within tissues, and subcellular compartments. The liver plays an essential role in maintaining whole-body metabolic homeostasis and is structurally defined by metabolic zones. These zones are well-understood on the transcriptomic level, but have not been comprehensively characterized on the metabolomic level. Mass spectrometry imaging (MSI) can be used to map hundreds of metabolites directly from a tissue section, offering an important advance to investigate metabolic heterogeneity in tissues compared to extraction-based metabolomics methods that analyze tissue metabolite profiles in bulk. We established a workflow for the preparation of tissue specimens for matrix-assisted laser desorption/ionization (MALDI) MSI and achieved broad coverage of central carbon, nucleotide, and lipid metabolism pathways. We used this approach to visualize the effect of nutrient stress and excess on liver metabolism. Our data revealed a highly organized metabolic compartmentalization in livers, which becomes disrupted under nutrient stress conditions. Fasting caused changes in glucose metabolism and increased the levels of fatty acids in the circulation. In contrast, a prolonged high-fat diet (HFD) caused lipid accumulation within liver tissues with clear zonal patterns. Fatty livers had higher levels of purine and pentose phosphate related metabolites, which generates reducing equivalents to counteract oxidative stress. This MALDI MSI approach allowed the visualization of liver metabolic compartmentalization at high resolution and can be applied more broadly to yield new insights into metabolic heterogeneityin vivo.
TopHap: Rapid inference of key phylogenetic structures from common haplotypes in large genome collections with limited diversity
Authors: Caraballo-Ortiz Marcos A. , Miura Sayaka , Sanderford Maxwell , Dolker Tenzin , Tao Qiqing , Weaver Steven , Pond Sergei L. K. , Kumar Sudhir
Published: December 2021

Motivation

Building reliable phylogenies from very large collections of sequences with a limited number of phylogenetically informative sites is challenging because sequencing errors and recurrent/backward mutations interfere with the phylogenetic signal, confounding true evolutionary relationships. Massive global efforts of sequencing genomes and reconstructing the phylogeny of SARS-CoV-2 strains exemplify these difficulties since there are only hundreds of phylogenetically informative sites and millions of genomes. For such datasets, we set out to develop a method for building the phylogenetic tree of genomic haplotypes consisting of positions harboring common variants to improve the signal-to-noise ratio for more accurate phylogenetic inference of resolvable phylogenetic features.

Results

We present the TopHap approach that determines spatiotemporally common haplotypes of common variants and builds their phylogeny at a fraction of the computational time of traditional methods. To assess topological robustness, we develop a bootstrap resampling strategy that resamples genomes spatiotemporally. The application of TopHap to build a phylogeny of 68,057 genomes (68KG) produced an evolutionary tree of major SARS-CoV-2 haplotypes. This phylogeny is concordant with the mutation tree inferred using the co-occurrence pattern of mutations and recovers key phylogenetic relationships from more traditional analyses. We also evaluated alternative roots of the SARS-CoV-2 phylogeny and found that the earliest sampled genomes in 2019 likely evolved by four mutations of the most recent common ancestor of all SARS-CoV-2 genomes. An application of TopHap to more than 1 million genomes reconstructed the most comprehensive evolutionary relationships of major variants, which confirmed the 68KG phylogeny and provided evolutionary origins of major variants of concern.

Availability

TopHap is available on the web at https://github.com/SayakaMiura/TopHap.

Contact

s.kumar@temple.edu
Mitochondrial Dysfunction is a Driver for SP-2509 Drug Resistance in Ewing Sarcoma
Authors: Tokarsky E. John , Crow Jesse C. , Guenther Lillian M. , Sherman John , Taslim Cenny , Alexe Gabriela , Pishas Kathleen I. , Rask Galen , Justis Blake S. , Kasumova Ana , Stegmaier Kimberly , Lessnick Stephen L. , Theisen Emily R.
Published: December 2021

Expression of the fusion oncoprotein EWS/FLI causes Ewing sarcoma, an aggressive pediatric tumor characterized by widespread epigenetic deregulation. These epigenetic changes are targeted by novel lysine specific demethylase-1 (LSD1) inhibitors, which are currently in early phase clinical trials. Single agent targeted therapy often induces resistance, and successful clinical development requires knowledge of resistance mechanisms, enabling the design of effective combination strategies. Here, we used a genome-scale CRISPR-Cas9 loss-of-function screen to identify genes whose knockout (KO) conferred resistance to the LSD1 inhibitor SP- 2509 in Ewing sarcoma cell lines. Multiple genes required for mitochondrial electron transport chain (ETC) complexes III and IV function were hits in our screen. We validated this finding using genetic and chemical approaches including CRISPR KO, ETC inhibitors, and mitochondrial depletion. Further global transcriptional profiling revealed that altered complex III/IV function disrupted the oncogenic program mediated by EWS/FLI and LSD1 and blunted the transcriptomic response to SP-2509. These findings demonstrate that mitochondrial dysfunction modulates SP-2509 efficacy and suggest that new therapeutic strategies combining LSD1 with agents which prevent mitochondrial dysfunction may benefit patients with this aggressive malignancy.
Arousal elevation drives the development of oscillatory vocal output
Authors: Zhang Yisi S. , Alvarez John L. , Ghazanfar Asif A.
Published: December 2021

Adult behaviors, such as vocal production, often exhibit temporal regularity. In contrast, their immature forms are more irregular. We ask whether the coupling of motor behaviors with arousal changes give rise to temporal regularity. Do they drive the transition from variable to regular motor output over the course of development? We used marmoset monkey vocal production to explore this putative influence of arousal on the nonlinear changes in their developing vocal output patterns. Based on a detailed analysis of vocal and arousal dynamics in marmosets, we put forth a general model incorporating arousal and auditory-feedback loops for spontaneous vocal production. Using this model, we show that a stable oscillation can emerge as the baseline arousal increases, predicting the transition from stochastic to periodic oscillations observed during marmoset vocal development. We further provide a solution for how this model can explain vocal development as the joint consequence of energetic growth and social feedback. Together, we put forth a plausible mechanism for the development of arousal-mediated adaptive behavior.
TXM-Sandbox: an open-source software for transmission X-ray microscopy data analysis
Authors: Xiao Xianghui , Xu Zhengrui , Lin Feng , Lee Wah-Keat
Published: December 2021

A transmission X-ray microscope (TXM) can investigate morphological and chemical information of a tens to hundred micrometre-thick specimen on a length scale of tens to hundreds of nanometres. It has broad applications in material sciences and battery research. TXM data processing is composed of multiple steps. A workflow software has been developed that integrates all the tools required for general TXM data processing and visualization. The software is written in Python and has a graphic user interface in Jupyter Notebook. Users have access to the intermediate analysis results within Jupyter Notebook and have options to insert extra data processing steps in addition to those that are integrated in the software. The software seamlessly integrates ImageJ as its primary image viewer, providing rich image visualization and processing routines. As a guide for users, several TXM specific data analysis issues and examples are also presented.
How does perceived severity of COVID-19 influence purchase intention of organic food?
Authors: Wang Hong , Ma Baolong , Cudjoe Dan , Bai Rubing , Farrukh Muhammad
Published: December 2021

Purpose

The COVID-19 outbreak has been rapidly spreading around the world for more than a year. However, few studies have explored the connection between the perceived severity of COVID-19 and purchase intention of the health-related products, for example, organic food. Based on the stimulus–organism–response (S-O-R) framework, this study examines the influencing mechanism of perceived severity of COVID-19 on purchase intention of organic food.

Design/methodology/approach

To evaluate the proposed model, an online survey was utilized to collect 1,104 valid questionnaires from China.

Findings

The findings suggest that (1) the perceived severity of COVID-19 has a significant positive impact on purchasing intention; (2) health consciousness acts as a mediating role between perceived severity of COVID-19 and purchasing intention and (3) perceived inconvenience negatively moderates the connection between perceived severity and purchase intention.

Originality/value

The findings of this paper provide new insights into the positive effects of COVID-19 and pave the way for governments and enterprises to promote the purchase behaviour of organic food.
Development of a sustainable brand identity model: fostering the implementation of SDGs in the Brazilian power sector
Authors: Caldana Adriana Cristina Ferreira , Lourenção Marina , Krüger Caroline , Pennabel Adriana Fiorani , dos Santos Neusa Maria Bastos Fernandes
Published: December 2021

Purpose

This study aims to develop a sustainable brand identity model to help organizations align their managerial practices to sustainable development goals (SDGs) and examine its applicability for a Brazilian electrical sector company.

Design/methodology/approach

A systematic qualitative review of the literature was carried out to provide a theoretical basis for the attributes chosen to compose the sustainable brand identity management (SBIM) model. To apply the model, the authors collected the data from internal and public domain documents, semi-structured in-depth interviews and non-participant observation of the company's work environment.

Findings

The first SBIM model was developed. The Brazilian power sector company implemented sustainable actions related to most of the models' attributes, contributing to the SDGs. A research agenda was presented.

Research limitations/implications

The theoretical contribution is provided toward brand identity and sustainability literature with the sustainable brand identity model development and the conceptual explanation regarding its attributes.

Practical implications

The practical implications are provided from the model application to an electrical company leading to some managerial suggestions that might be used to companies willing to align their practices to sustainability.

Originality/value

The studies on SDG and brand identity models were analyzed in order to create the first SBIM model. This article extends the concept of the brand identity of marketing theory by linking its core to sustainability actions, so far not addressed in academic studies.
The impact of user innovator mindset on feedback volume, feedback diversity and new product development performance
Authors: Wu Jiajun , O'Hern Matthew , Ye Jun
Published: December 2021

Purpose

This study examines the influence of different user innovator mindsets on new product development (NPD) performance. The current research explores the relative impact of a product-focused user innovator mindset vs a customer-focused mindset on feedback volume and feedback diversity and investigates the effect of each type of feedback on product improvement and product diffusion.

Design/methodology/approach

This study examines these relationships using two distinct types of data. Data on user innovator mindset, feedback characteristics and user innovator improvisation were obtained via an online survey. Archival data on NPD performance measures were acquired directly from an online research database, and results were obtained using confirmatory factor analysis.

Findings

The authors find that while neither type of user innovator mindset directly influences NPD performance, user innovators, who are highly customer-focused, have a significant advantage in sourcing knowledge from users in the form of a higher volume of feedback and more diverse feedback. In turn, feedback volume appears to positively influence product improvement, while feedback diversity positively influences product diffusion. Finally, the effect of both types of feedback on product improvement is enhanced for user innovators who are highly improvisational.

Originality/value

This research highlights the important role that customer focus plays in directly obtaining knowledge from customers (i.e. customer feedback) and the effects of that feedback on NPD performance. This study provides evidence that a user innovator's interest in accurately understanding the needs of their peers improves their access to external knowledge and enhances their innovation efforts.
The industrial relations chameleon: collective bargaining in the facility management business
Authors: Godino Alejandro , Molina Oscar
Published: December 2021

Purpose

The paper aims to analyze collective bargaining in the facility management business of these six countries to explore similarities and differences between them. The analysis serves to test the differential impact of the national institutional setting on the protection provided by collective agreements to facility management workers.

Design/methodology/approach

The paper adopts a case study methodology to approach a facility management multinational company providing services in six European countries (France, Italy, The Netherlands, Poland, Spain and the UK) that represent different industrial relations systems with variance in key dimensions of collective bargaining, including its structure, coverage and extension of agreements.

Findings

The extension of the facility management business model has not always adopted a high-road strategy aimed at enhancing the quality and efficiency through the integrated management and delivery of services, which is expected to positively impact employment conditions. Rather, it has, in many cases, been a deliberate, low-road attempt to undercut working standards, taking advantage of the multiple services provided by the company in a context of growing de-centralization in collective bargaining. The results point to an important role of industrial relations institutions in shaping facility management strategies and outcomes.

Originality/value

Similar to other forms of outsourcing, facility management leads to fragmented employment relations. However, the concentration of outsourced workers under the same supplier organization introduces opportunities to ensure the protection of workers, depending on the adoption of a high- or low-road competitive strategy. This paper provides for the first time comparative evidence about industrial relations in facility management businesses, a largely under-researched area.
Reliability degradation prediction of photovoltaic modules based on dependability methods
Authors: Hefaidh Hadef , Mébarek Djebabra , Belkhir Negrou , Driss Zied
Published: December 2021

Purpose

The reliability prediction is among the most important objectives for achieving overall system performance, and this prediction carried out by anticipating system performance degradation. In this context, the purpose of this research paper is to development of methodology for the photovoltaic (PV) modules' reliability prediction taking into account their future operating context.

Design/methodology/approach

The proposed methodology is framed by dependability methods, in this regard, two methods of dysfunctional analysis were used, the Failure Mode and Effects Criticality Analysis (FMECA) method is carried out for identification of the degradation modes, and the Fault Tree Analysis (FTA) method is used for identification the causes of PV modules degradation and the parameters influencing its degradation. Then, based on these parameters, accelerated tests have been used to predict the reliability of PV modules.

Findings

The application of the proposed methodology on PWX 500 PV modules' in different regions of Algeria makes it possible to predict its reliability, taking into account the future constraints on its operation. In this case, the temperature and relative humidity vary from one region to another was chosen as constraints. The results obtained from the different regions confirms the reliability provided by the designer of the Saharan cities Biskra, In Salah, Tamanraset, and affirms this value for the two Mediterranean cities of Oran and Algiers.

Originality/value

The proposed methodology is developed for the reliability prediction of the PV modules taking into account their future operating context and, the choice of different regions confirms or disproves the reliability provided by the designer of the PV modules studied. This application confirms their performance within the framework of the reliability prediction.
Deming’s tampering revisited: definition and future research agenda
Authors: Smeds Magdalena
Published: December 2021

Purpose

How do organisations know which problems are worthy of their attention? Despite good intentions, many attempts to solve problems fail. One reason for this failure might be because of attempts to solve non-problems or to solve problems with insufficient means, a concept proposed by Deming as tampering. The purpose of this paper is to suggest a definition of tampering, outline what is currently known about possible practical implications of tampering and to suggest how to extend this knowledge by proposing an agenda for future research.

Design/methodology/approach

To fulfil the purpose, a narrative literature review was conducted.

Findings

Through this review, common aspects of what constitutes tampering are identified and the following definition is proposed: Tampering is a response to a perceived problem in the form of an action that is not directed at the fundamental cause of the problem, which leads to a deterioration of the process or the process output. In addition, recommendations are generated regarding how tampering manifests itself in practice and why tampering occurs. These recommendations could be studied in future research.

Originality/value

To the best of the authors’ knowledge, this is the first paper that suggests a revitalisation of tampering. The results presented in this paper form the basis for continued studies on how tampering in organisations can be understood, managed and prevented.
Assessment of women accessibility to health-care facilities in a typical rural local government area in Nigeria
Authors: Adeniyi Lateef Adeleke , Fatoke Michael Temidayo , Adesoye Oluyemi Peter , Folorunso Sikiru Akintunde , Lawal Adekunle Adedeji
Published: December 2021

Purpose

This study aims to assess the accessibility of women to health-care facilities in the rural areas with a view to unties possible recommendation of enhancing its service delivery. It provides an insight into the levels of satisfaction of the services provided by conventional health-care providers in the area where the majority in the developing countries concentrated. The study unravels the reasons for the low patronage of regular health-care facilities to boost unscientific ones by rural women.

Design/methodology/approach

The study relies on extensive field work conducted in the study area mainly rural nature. data was sourced by questionnaire, mainly administered on the women in the area and field observation. Data collected were analysed using descriptive statistics.

Findings

The paper provides information on the low socio-economic attributes of rural women. It is further showed that medical facilities and personnel were not relatively available and performed in health-care centres to the satisfaction of the users. Poor roads, poor human relation, low quality of services, inadequate medical personnel and drug shortage hindrance to women accessing appropriate health-care facilities in the rural areas. Rural women, therefore, opted for self-medication folk medicine, disguising and spiritual remedies. Health-care facilities suffered poor patronage as a result of these obstacles The study recommended proper overhauling of health-care facilities.

Originality/value

The paper builds a relationship on the reasons for health-care facilities neglect in the rural area in developing countries and revealed unscientific means by which health care needs are realised rural women.
Developing multicultural leaders through online language immersion
Authors: Courtney Matthew B.
Published: December 2021

Purpose

This study aims to document the impact of an 80-h virtual Spanish language immersion program on four elementary school leaders in Kentucky.

Design/methodology/approach

This study used a mixed methods approach. Each subject participated in three semi-structured interviews with the researcher and a standardized oral language assessment.

Findings

Participants expressed greater confidence when interacting with students and families who do not speak English, greater empathy for students learning English, new cross-cultural understandings and deeper knowledge about the language acquisition process and language instruction.

Practical implications

Training in a foreign language may prove to be a valuable professional learning activity for leaders seeking to develop a stronger skillset and mindset for multicultural education.

Originality/value

This paper contributes to the literature by documenting a previously un-researched virtual language immersion program.
The iodine knowledge of pregnant women in an endemic goiter area: a cross-sectional study
Authors: Aslan Çin Nazlı Nur , Özçelik Ayşe Özfer
Published: December 2021

Purpose

This study aims to determine the level of knowledge about iodine nutrition during pregnancy among pregnant women living in the area of Turkey where goiter is endemic.

Design/methodology/approach

A total of 150 pregnant women aged between 19 and 45 years, registered at the Gynaecology and Obstetrics Clinic in Trabzon were recruited. The data was collected through a voluntary face-to-face survey with pregnant women. The questionnaire comprising questions determining the sociodemographic characteristics of the participants, data concerning any previous pregnancy, iodized salt consumption habits and knowledge about iodine.

Findings

Although 68% of the women knew that iodine deficiency can cause serious consequences during pregnancy, the remainder did not. The three main dietary sources of iodine in Turkey are fish, cow’s milk and table salt; of the women, 68%, 20% and 77.3%, respectively, correctly identified these as good sources. The more educated of the pregnant women had significantly higher knowledge scores (p < 0.001). However, age, trimester, parity and previous receipt of information about iodine and iodine knowledge scores made no significant differences.

Research limitations/implications

This study may not be generalizable for all pregnant women.

Originality/value

To the best of the authors’ knowledge, this study is the first pilot study to evaluate the level of knowledge regarding iodine among pregnant women in Turkey.
Institutional investor management of Australian healthcare property assets as a pandemic-proof asset class
Authors: Marzuki Muhammad Jufri , Newell Graeme
Published: December 2021

Purpose

As the prolonged effect of the COVID-19 pandemic has materially impacted investment returns significantly, it is more crucial than ever for institutional investors to redefine their property portfolios using assets with better investment management potential and meaningful diversification benefits. The “alternative asset revolution” is gaining traction in the property investment space internationally among institutional investors due to the shifting investment attitudes towards the alternative property sectors. Australia's $205bn healthcare property sector is at the forefront of this revolution due to its societal significance, as well as its attractive investment qualities. This paper investigates the institutional investor management of the Australian healthcare property sector via both the direct and listed channels and empirically analyses its investment attributes.

Design/methodology/approach

Using the unique Morgan Stanley Capital International/Property Council of Australia quarterly data set for Australian direct healthcare property over 2006–2020, the risk-adjusted performance and portfolio diversification potential direct healthcare property and listed healthcare were assessed. A constrained mean-variance portfolio optimisation framework was used to develop a six-asset portfolio scenario to analyse the portfolio added-value benefits of both direct healthcare property and listed healthcare in a mixed-asset investment strategy. A similar set of analysis was performed using the post-global financial crisis (GFC) quarterly time series of 2009–2020 to investigate the healthcare asset class' performance dynamics in the post-GFC investment timeframe.

Findings

The results indicate that direct healthcare property and listed healthcare offer two key advantages for institutional investors in managing their property portfolios: (1) a stable yet superior risk-adjusted performance and (2) significant portfolio diversification potential in managing their property portfolios. Importantly, both direct healthcare property and listed healthcare provided valuable contributions in strengthening an investment portfolio's performance. The post-GFC sub-period analysis revealed a consistent conclusion regarding the healthcare asset class's performance attributes.

Originality/value

This is the first research that provides an independent empirical examination of the strategic importance of Australian healthcare property as a maturing alternative property sector that can serve both investment and environmental, social and governance goals of investors. This research presents a positive investment prognosis for the Australian healthcare property sector to achieve its institutionalised status as a mainstream asset class of the future.
Can gold hedge against inflation in the UAE? A nonlinear ARDL analysis in the presence of structural breaks
Authors: Al-Nassar Nassar S.
Published: December 2021

Purpose

The purpose of this study is to explore the role of gold as a hedge against inflation in the case of the United Arab Emirates.

Design/methodology/approach

The study utilizes monthly data on the local sharia-compliant spot gold contract traded on the Dubai Gold and Commodity Exchange (DGCX) and the corresponding consumer price index series over the period December 2015 to January 2021. The econometric approach employed by the study involves a unit root testing procedure that allows the timing of significant breaks to be estimated. A cointegration analysis is then conducted using a nonlinear autoregressive distributed lag (NARDL) model, taking into consideration the presence of structural breaks in addition to short- and long-run asymmetries.

Findings

The results reveal that consumer and gold prices are cointegrated, which implies that investing in gold can hedge against inflation in the long run. No sufficient evidence, nonetheless, is found in support of the ability of gold to serve as a hedge against inflation in the short run.

Originality/value

The findings have several important policy implications for policymakers and investors that are further discussed in the study.
Whiteness from the top down: systemic change as antiracist action in LIS
Authors: Jennings Alyssa , Kinzer Kristine
Published: December 2021

Purpose

The purpose of the paper is two-fold. The first is to inform the readers of the racist origins of libraries in America. Readers will learn about historic instances of systemic racism in libraries and those that persist today. The second purpose is to give readers examples of antiracist actions they can take on an individual level, in concert with library administration, and on the institutional level.

Design/methodology/approach

This paper gives an overview of systemic racism in librarianship. Part I outlines the history of libraries and their institutional oppression origins in America. Part II reviews some of the current racial issues in Libraries and Information Science (LIS). Part III gives the author's viewpoint on how to incorporate antiracist action within libraries and how to decenter whiteness at the national level.

Findings

The authors found that libraries were established on institutional oppression and systemic racism, which continue to this day to center whiteness and disadvantage BIPOC. Having said that, now is the time to make changes, decenter whiteness and remove systemic barriers through antiracist actions. These actions will help increase the number of BIPOC working in libraries and improve the retention and promotion of those BIPOC too. If the American Library Association (ALA) heeds this call to action, Critical Race Theory (CRT) will become part of the Master's of Library and Information Science (MLIS), BIPOC will be better funded and supported, and the credentialing stigma will be removed.

Originality/value

This article highlights concrete action that should be taken beyond individual bias awareness and into systemic changes. It advocates for more critical awareness and daily antiracist action within the LIS field.
Externalisation in family‐based treatment of anorexia nervosa: The therapist's experience
Authors: Lonergan Katie , Whyte Aileen , Ryan Christian
Published: December 2021

Family‐based treatment (FBT) is an evidence‐based treatment for adolescent eating disorders that incorporates many principles from family therapy. It uses the externalisation of anorexic thoughts and behaviours to separate the person from the anorexia nervosa (AN) through language and metaphor. Little is known about how clinicians understand, conceptualise and support families to externalise. Semi‐structured interviews conducted with FBT‐trained clinicians working in child and adolescent mental health services were analysed using thematic analysis. Three themes emerged: the clinician’s use of externalisation, the impact on family functioning and the barriers to externalisation. Externalisation can support a young person’s recovery from AN when used in conjunction with other therapeutic skills. Clinicians should be aware of potential barriers to the implementation of externalisation, such as problem awareness, age and duration of illness.

Practitioner points

Clinicians value externalisation as an important therapeutic technique within the FBT model, while acknowledging that the ‘ED as illness’ metaphor can challenge their own beliefs.

Externalisation can improve family functioning, family communication and reducing conflict within relationships in families with AN.

Lack of insight into the AN can present as a barrier to externalisation for a young person.