bluuebunny/crossref_metadata_2025 huggingface dataset:
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors
Authors: Wittlinger Florian , Ogboo Blessing C. , Shevchenko Ekaterina , Damghani Tahereh , Pham Calvin D. , Schaeffner Ilse K. , Oligny Brandon T. , Chitnis Surbhi P. , Beyett Tyler S. , Rasch Alexander , Buckley Brian , Urul Daniel A. , Shaurova Tatiana , May Earl W. , Schaefer Erik M. , Eck Michael J. , Hershberger Pamela A. , Poso Antti , Laufer Stefan A. , Heppner David E.
Published: February 2024

Bivalent molecules consisting of groups connected through bridging linkers often exhibit strong target binding and unique biological effects. However, developing bivalent inhibitors with the desired activity is challenging due to the dual motif architecture of these molecules and the variability that can be introduced through differing linker structures and geometries. We report a set of alternatively linked bivalent EGFR inhibitors that simultaneously occupy the ATP substrate and allosteric pockets. Crystal structures show that initial and redesigned linkers bridging a trisubstituted imidazole ATP-site inhibitor and dibenzodiazepinone allosteric-site inhibitor proved successful in spanning these sites. The re-engineered linker yielded a compound that exhibited significantly higher potency (~60 pM) against the drug-resistant EGFR L858R/T790M and L858R/T790M/C797S, which was superadditive as compared with the parent molecules. The enhanced potency is attributed to factors stemming from the linker connection to the allosteric-site group and informs strategies to engineer linkers in bivalent agent design.
Catalytic thiolation-depolymerization-like decomposition of oxyphenylene-type super engineering plastics via selective carbon–oxygen main chain cleavages
Authors: Minami Yasunori , Imamura Sae , Matsuyama Nao , Nakajima Yumiko , Yoshida Masaru
Published: February 2024

As the effective use of carbon resources has become a pressing societal issue, the importance of chemical recycling of plastics has increased. The catalytic chemical decomposition for plastics is a promising approach for creating valuable products under efficient and mild conditions. Although several commodity and engineering plastics have been applied, the decompositions of stable resins composed of strong main chains such as polyamides, thermoset resins, and super engineering plastics are underdeveloped. Especially, super engineering plastics that have high heat resistance, chemical resistance, and low solubility are nearly unexplored. In addition, many super engineering plastics are composed of robust aromatic ethers, which are difficult to cleave. Herein, we report the catalytic depolymerization-like chemical decomposition of oxyphenylene-based super engineering plastics such as polyetheretherketone and polysulfone using thiols via selective carbon–oxygen main chain cleavage to form electron-deficient arenes with sulfur functional groups and bisphenols. The catalyst combination of a bulky phosphazene base P4-tBu with inorganic bases such as tripotassium phosphate enabled smooth decomposition. This method could be utilized with carbon- or glass fiber-enforced polyetheretherketone materials and a consumer resin. The sulfur functional groups in one product could be transformed to amino and sulfonium groups and fluorine by using suitable catalysts.
Enhancing Cu–ligand interaction for efficient CO2 reduction towards multi-carbon products
Authors: Chen Jingyi , Fan Lei , Zhao Yilin , Yang Haozhou , Wang Di , Hu Bihao , Xi Shibo , Wang Lei
Published: February 2024

Here, we report Cu-DAT (3,5-diamino-1,2,4-triazole) for efficient CO2 reduction. By optimizing the Cu/ligand cooperation, accelerated *CO adsorption and C–C coupling were achieved, demonstrating >80% C2+ products selectivity at 400 mA cm−2.
[Ag(Sn9–Sn9)]5− and [(η4-Sn9)Ag(η1-Sn9)]7−, as aggregates of spherical aromatic building blocks. Persistence of aromaticity upon cluster gathering
Authors: Rodríguez-Kessler Peter L. , Muñoz-Castro Alvaro
Published: February 2024

Formation of cluster-based materials requires a fundamental understanding of the resulting cluster aggregation processes.
Strong electron–phonon coupling and high lattice thermal conductivity in half-Heusler thermoelectric materials
Authors: Wang Ruoyu , Cai Jianfeng , Zhang Qiang , Tan Xiaojian , Wu Jiehua , Liu Guoqiang , Jiang Jun
Published: February 2024

In 19-e half-Heusler compounds, the strong d–d bonding is weakened by the extra valence electron occupying the antibonding states. Thus, the high lattice thermal conductivity of 18-e half-Heusler compounds is significantly reduced.
A novel approach to amino acid synthesis: acid-assisted reactions with dimethyl carbonate for efficient O-methylated, N,O-methylated and N-formylated derivatives
Authors: Worsawat Pattamabhorn , Noppawan Pakin , Supanchaiyamat Nontipa , Wu Himmy , McElroy Con R. , Hunt Andrew J.
Published: February 2024

A novel and efficient method has been developed for the modification of amino acids using a dimethyl carbonate (DMC) in an acidic system.
Strong, tough and anisotropic bioinspired hydrogels
Authors: Wang Shu , Lei Ling , Tian Yuanhao , Ning Huiming , Hu Ning , Wu Peiyi , Jiang Hanqing , Zhang Lidan , Luo Xiaolin , Liu Feng , Zou Rui , Wen Jie , Wu Xiaopeng , Xiang Chenxing , Liu Jie
Published: February 2024

A novel solvent–exchange-assisted wet-stretching strategy is proposed to prepare anisotropic PVA hydrogels by tuning the macromolecular chain movement and optimizing the polymer network. These hydrogels exhibit excellent mechanical properties.
Green-chemistry synthesis and optical properties of lead-free Cs2AgSbCl6 double perovskite by a mechanochemical method
Authors: Barbosa Karla Kariny F. , Aristizábal-Giraldo Deisy , Osorio-Guillén Jorge M. , Acuña José Javier S. , Ferreira Fabio F.
Published: February 2024

Cs2AgSbCl6 double perovskite (DP) has been synthesized through many solid-state and solution routes.
Ball-milling for efficient synthesis of pyridine-containing iron(ii) photosensitizers
Authors: Rastoder Enita , Michel Thierry , Lamaty Frédéric , Bantreil Xavier
Published: February 2024

The use of a ball-mill allowed the efficient one-pot synthesis of iron complexes, involving self-assembly of the ligands, in short reaction times (<1 h). In situ Raman monitoring indicated the fast formation of the ligand and further metalation.
Synergistic purification of chromium-containing wastewater via adsorption-photocatalysis induced by multiple defect-containing CuS/Cv-CNNs
Authors: Wang Luhua , Ren Yi , Zhao Hongfang , Li Hongxia , Niu Xiaohui , Zhang Deyi , Fan Haiyan , Wang Kunjie
Published: February 2024

A defective CuS/Cv-CNNs heterojunction is proposed, which promotes its adsorption and photodegradation of Cr(vi) through the synergistic effect of multiple defects, thus accelerating the removal of high concentrations of Cr(vi).
Water-enabling strategies for asymmetric catalysis
Authors: Wen Gang , Feng Xiaoming , Lin Lili
Published: February 2024

Water-enabling strategies in the last decade were summarized, especially those clarifying how water affects a reaction.
Catalytic [4 + 1]-annulation of thioamides with carbenoid precursors
Authors: Ilkin Vladimir G. , Filimonov Valeriy O. , Utepova Irina A. , Beryozkina Tetyana V. , Slepukhin Pavel A. , Tumashov Andrey A. , Dehaen Wim , Bakulev Vasiliy A.
Published: February 2024

Catalyst-controlled regioselective and diastereoselective reactions of thioamides with diazoamides and 1-sulfonyl-1,2,3-triazoles was developed. Enantioselective and gram-scale syntheses were performed.
Theoretical prediction of nanosizing effects and role of additives in the decomposition of Mg(BH4)2
Authors: Pantaleone Stefano , Albanese Elisa , Donà Lorenzo , Corno Marta , Baricco Marcello , Civalleri Bartolomeo
Published: February 2024

Nanosizing effects and role of additives in the decomposition of Mg(BH4)2 were studied by DFT modelling. Decomposition is favoured at the nanoscale with respect to the bulk along with a major catalytic effect of Ni compared to Cu.
Synthesis of a sustainable and robust heterogeneous TEMPO catalyst utilizing activated carbon for aerobic alcohol oxidation
Authors: Luo Jing , Zhang Chenghao , Liu Wei , Li Yingying , Xie Bingqi , Zhang Jisong
Published: February 2024

Ozone-induced surface-carbonylation and reductive amination to construct stable TEMPO grafting on activated carbon with prominent durability and prolonged lifetime.
Na-ion dynamics in the solid solution NaxCa1−xCr2O4 studied by muon spin rotation and neutron diffraction
Authors: Nocerino Elisabetta , Forslund Ola Kenji , Sakurai Hiroya , Matsubara Nami , Zubayer Anton , Mazza Federico , Cottrell Stephen , Koda Akihiro , Watanabe Isao , Hoshikawa Akinori , Saito Takashi , Sugiyama Jun , Sassa Yasmine , Månsson Martin
Published: February 2024

Thermally activated Na diffusion mechanism in the honeycomb-like 1D channels of the solid solution NaxCa1−xCr2O4.
Approximation of extracted features enabling 3D design tuning for reproducing the mechanical behaviour of biological soft tissues
Authors: Serantoni Vincent , Rouby Corinne , Heller Ugo , Boisson Jean
Published: February 2024

A machine learning inspired method to mimic the mechanical behaviour of biological soft tissues is described. The tuned composite, based on Bézier curves, gives good results in the experimental reproduction of mandibular and calvarial periosteum.
On-surface magnetocaloric effect for a van der Waals Gd(iii) 2D MOF grown on Si
Authors: Kumar Subodh , Riera Guillem Gabarró , Arauzo Ana , Hrubý Jakub , Hill Stephen , Bogani Lapo , Rubio-Zuazo Juan , Jover Jesús , Bartolomé Elena , Sañudo E. Carolina
Published: February 2024

[Gd(MeCOO)(PhCOO)2], a 2D MOF is reported and characterized, the material shows a magnetocaloric effect both in bulk and chemisorbed on a Silicon substrate. This opens up the possibilities for on-surface cooling devices.
High-throughput screening for efficient dual-atom catalysts in electrocatalytic nitrate reduction to ammonia via dissociation–association mechanism
Authors: Lv Lingling , Shen Yanqing , Zhou Min , Zhang Yu , Meng Xianghui , Yang Xin , Zhang Nan , Wang Kexin , He Qirui , Gong Dewei , Ai Qing , Shuai Yong , Zhou Zhongxiang
Published: February 2024

Due to the synergistic effect of dual-atom metals, dual-atom catalysts M1M2/g-C3N4 differ from single-atom catalysts in that they follow a distinct dissociation–association reaction mechanism.
Mussel-inspired PDA@PEDOT nanocomposite hydrogel with excellent mechanical strength, self-adhesive, and self-healing properties for a flexible strain sensor
Authors: Li Xiaoyi , Zhao Xueshan , Liu Ruiqi , Wang Hui , Wang Shuang , Fan Bing , Hu Chenggong , Wang Haibo
Published: February 2024

Conductive hydrogel sensors have attracted attention for use in human motion monitoring detection, but integrating excellent biocompatibility, mechanical, self-adhesive, and self-healing properties, and high sensitivity into a hydrogel remains a challenge.
A superhydrophobic MOF facilitating efficient solvent-free catalytic chemical fixation of CO2 and oxidation of hydrocarbons and MOF@cotton@starch composite-based selective sensing of a herbicide
Authors: Ghosh Subhrajyoti , Mukherjee Srijan , Karthik Veerappan , Bera Priti , Dhakshinamoorthy Amarajothi , Biswas Shyam
Published: February 2024

Superhydrophobic Zr-MOF unveils solvent-free chemical fixation of CO2 at 1 bar, along with efficient aerobic oxidation of hydrocarbons into fine chemicals and fast, nanomolar detection of aclonifen in wastewater, vegetables, and fruits.
Catalytic utility of PNN-based MnI pincer complexes in the synthesis of quinolines and transfer hydrogenation of carbonyl derivatives
Authors: Mohite Manali A. , Sheokand Sonu , Mondal Dipanjan , Balakrishna Maravanji S.
Published: February 2024

This manuscript describes the synthesis and MnI complexes of triazolyl-pyridine-based phosphine ligand and their catalytic utility in the synthesis of quinoline derivatives and transfer hydrogenation of aldehydes and ketones.
A silver and manganese dioxide composite with oxygen vacancies as a high-performance cathode material for aqueous zinc-ion batteries
Authors: Wang Yun , Wang Tengfei , Zhang Wenjing , Li Liangjun , Lv Xiaoxia , Wang Hua
Published: February 2024

An oxygen vacancy-enriched silver and manganese dioxide composite was prepared by liquid-phase reduction method, which can be used to construct aqueous zinc ion batteries and exhibits excellent capacity and cycling performance.
Soy protein hydrogels with filler emulsion particles coated by hydrolyzed protein
Authors: Liang Guijiang , Chen Wenpu , Zeng Maomao , He Zhiyong , Chen Jie , Wang Zhaojun
Published: February 2024

This study highlights that soy protein with pepsin-derived hydrolysis (SPHPe) enhances its emulsifying properties, and gels filled with SPHPe emulsion exhibit a significant increase in gel strength and water-holding capacity.
Investigation of the intermolecular origins of high and low heats of fusion in azolium salt phase change materials for thermal energy storage
Authors: Saher Saliha , Piper Samantha L. , Forsyth Craig M. , Kar Mega , MacFarlane Douglas R. , Pringle Jennifer M. , Matuszek Karolina
Published: February 2024

Azolium salts are potential intermediate-temperature phase change materials. Crystallographic analysis shows that H-bonding along with other intermolecular interactions strongly influence the melting enthalpy of azolium salts.
Exploration of novel non-purine xanthine oxidase inhibitors based on oxadiazolones by an integrated simulation study
Authors: Xie Cheng , Zhai Na , Zheng Xiaojiao , Jiang Minghong , Zhao Yilan , Xu Zhiqiang , Sun Qi , Liu Genyan
Published: February 2024

A systematic simulation study on a novel series of oxadiazolones as xanthine oxidase inhibitors.
A defective bismuth–indium catalyst promotes water dissociation for selective carbon dioxide electroreduction to HCOOH
Authors: Zhou Jieshu , Li Liming , Ren Hangxing , Wang Haibin , Li Yong , Liu Kangning , Huang Liang , Yang Xinyao , Hao Zhen , Zhang Yuguang , Wang Zhichao , Wang Xi , Ding Jian , Ji Yuping , Wang Li , Liang Hongyan
Published: February 2024

A defective BiIn bimetallic catalyst derived from a P-doped BiIn pre-catalyst is developed, which enables CO2 conversion to HCOOH with high activity and selectivity.
A formal (3 + 2) annulation–Cannizzaro cascade of bifunctional peroxides for the synthesis of dihydrofurans
Authors: Chen Yiwei , Gao Min , Xu Qianlan , Zhang Jiumeng , Hu Lin
Published: February 2024

Tunable tandem processes of bifunctional peroxides allow the divergent construction of functionalized dihydrofurans and epoxides by simply changing the basic conditions.
Predicting band gaps of ABN3 perovskites: an account from machine learning and first-principle DFT studies
Authors: Ghosh Swarup , Chowdhury Joydeep
Published: February 2024

A combined machine learning and DFT studies in predicting band gaps of ABN3 perovskites.
Development of a selective and scalable N1-indazole alkylation
Authors: Wang Jimmy , Mccreanney Aaron , Taylor-Young Amelia , Fenton Harriet A. M. , Miah Rayyan , Johnson Rebecca A. , Clarke James , Hopkins Adam , Jones Ricky , Waddington William , Fussell Steven J. , Badland Matthew , Pibworth Benjamin , Walton Robert
Published: February 2024

A scalable and selective N1-alkylation of indazoles broad in scope and suitable for manufacturing scale.
Machine learning modelling for predicting the utilization of invasive and non‐invasive ventilation throughout the ICU duration
Authors: Schwager Emma , Nabian Mohsen , Liu Xinggang , Feng Ting , French Robin , Amelung Pam , Atallah Louis , Badawi Omar
Published: February 2024

The goal of this work is to develop a Machine Learning model to predict the need for both invasive and non‐invasive mechanical ventilation in intensive care unit (ICU) patients. Using the Philips eICU Research Institute (ERI) database, 2.6 million ICU patient data from 2010 to 2019 were analyzed. This data was randomly split into training (63%), validation (27%), and test (10%) sets. Additionally, an external test set from a single hospital from the ERI database was employed to assess the model's generalizability. Model performance was determined by comparing the model probability predictions with the actual incidence of ventilation use, either invasive or non‐invasive. The model demonstrated a prediction performance with an AUC of 0.921 for overall ventilation, 0.937 for invasive, and 0.827 for non‐invasive. Factors such as high Glasgow Coma Scores, younger age, lower BMI, and lower PaCO2 were highlighted as indicators of a lower likelihood for the need for ventilation. The model can serve as a retrospective benchmarking tool for hospitals to assess ICU performance concerning mechanical ventilation necessity. It also enables analysis of ventilation strategy trends and risk‐adjusted comparisons, with potential for future testing as a clinical decision tool for optimizing ICU ventilation management.
Comparative analysis of the hybrid gazelle‐Nelder–Mead algorithm for parameter extraction and optimization of solar photovoltaic systems
Authors: Ekinci Serdar , Izci Davut , Hussien Abdelazim G.
Published: February 2024

The pressing need for sustainable energy solutions has driven significant research in optimizing solar photovoltaic (PV) systems which is crucial for maximizing energy conversion efficiency. Here, a novel hybrid gazelle‐Nelder–Mead (GOANM) algorithm is proposed and evaluated. The GOANM algorithm synergistically integrates the gazelle optimization algorithm (GOA) with the Nelder–Mead (NM) algorithm, offering an efficient and powerful approach for parameter extraction in solar PV models. This investigation involves a thorough assessment of the algorithm's performance across diverse benchmark functions, including unimodal, multimodal, fixed‐dimensional multimodal, and CEC2020 benchmark functions. Notably, the GOANM consistently outperforms other optimization approaches, demonstrating enhanced convergence speed, accuracy, and reliability. Furthermore, the application of the GOANM is extended to the parameter extraction of the single diode and double diode models of RTC France solar cell and PV model of Photowatt‐PWP201 PV module. The experimental results consistently demonstrate that the GOANM outperforms other optimization approaches in terms of accurate parameter estimation, low root mean square values, fast convergence, and alignment with experimental data. These results emphasize its role in achieving superior performance and efficiency in renewable energy systems.
A data‐driven identification method for impedance stability analysis of inverter‐based resources
Authors: Wang Hongyi , Sun Pingyang , Sahebkar Farkhani Jalal , Chen Zhe
Published: February 2024

Obtaining inverter controller information may be a premise for seeking its dynamic behaviour. But accurate knowledge of such information would be unrealistic for real functioning inverter‐interfaced generators (IIGs), which hinders the stability analysis of the IIG. A new data‐driven impedance identification method is proposed for stability analysis, which involves an improved sparse identification algorithm as an ancillary function within the system identification framework. It contains mainly two design stages. First, the transform basis matrix (TBM) is devised systematically as a prior knowledge library to contain the possibly existing control structures. In the second stage, a sparse identification algorithm is reformulated in order to extract the relevant structures in TBM while obtaining controller parameters. The authors demonstrate that the sparse vector between the TBM and output signal is closely related to the controller structure. The effectiveness of the proposed method is verified on grid‐connected inverters based on droop control and virtual synchronous machine control.
Rheological characteristics and behaviour prediction of lubricating grease for RV reducer across a wide temperature range
Authors: Jiang Benchi , Zhou Yansheng , Tu Zhijian , Pan Jiabao
Published: February 2024

Grease in the normal operation of the rotate vector (RV) reducer has a role that cannot be ignored, for the variable working conditions of the RV reducer, the performance of the lubricant changes directly affect its reliable operation. Therefore, the study of the rheological properties of the grease has become the focus of the study of RV reducer performance. Here, SK‐1A grease is taken as the research object, and its rheological characteristics under wide temperature range working conditions (−20–40°C) are investigated through rheological experiments to analyze the potential influence of the performance of RV reducer. However, the ordinary way of research is too complicated to better research the rheological properties of grease for a variety of working conditions. The Elman neural network (ENN) model was used to predict the rheological properties, and the results were compared with those of back propagation (BP) and radial basis function (RBF) neural networks. The results demonstrate that the ENN model demonstrates high prediction accuracy for grease rheological property prediction by comparing three types of predictions. This method can provide a theoretical reference for the accurate prediction of the rheological properties of lubricating grease affected by complex multifactors.
Accretion of primordial H–He atmospheres in mini-Neptunes: The importance of envelope enrichment
Authors: Mol Lous M. , Mordasini C. , Helled R.
Published: February 2024

Context. Out of the more than 5000 detected exoplanets, a considerable number belong to a category called “mini-Neptunes”. Interior models of these planets suggest that they have primordial H–He-dominated atmospheres. As this type of planet is not found in the Solar System, understanding their formation is a key challenge in planet formation theory. Unfortunately, quantifying how much H–He planets have, based on their observed mass and radius, is impossible due to the degeneracy of interior models.

Aims. Another approach to estimating the range of possible primordial envelope masses is to use formation theory. As different assumptions in planet formation can heavily influence the nebular gas accretion rate of small planets, it is unclear how large the envelope of a protoplanet should be. We explore the effects that different assumptions regarding planet formation have on the nebular gas accretion rate, particularly by exploring the way in which solid material interacts with the envelope. This allows us to estimate the range of possible post-formation primordial envelopes. Thereby, we demonstrate the impact of envelope enrichment on the initial primordial envelope, which can be used in evolution models.

Methods. We applied formation models that include different solid accretion rate prescriptions. Our assumption is that mini-Neptunes form beyond the ice line and migrate inward after formation; thus, we formed planets in situ at 3 and 5 au. We considered that the envelope can be enriched by the accreted solids in the form of water. We studied how different assumptions and parameters influence the ratio between the planet’s total mass and the fraction of primordial gas.

Results. The primordial envelope fractions for low- and intermediate-mass planets (total mass below 15 M⊕) can range from 0.1% to 50%. Envelope enrichment can lead to higher primordial mass fractions. We find that the solid accretion rate timescale has the largest influence on the primordial envelope size.

Conclusions. Rates of primordial gas accretion onto small planets can span many orders of magnitude. Planet formation models need to use a self-consistent gas accretion prescription.
Designing an experimental method for assessing biocompatibility of circuit coatings using biomarkers for platelet activation during cardiopulmonary bypass
Authors: Sancheti Meghal , Rentschler Mitchell , Bolch Charlotte , Li Weidang , Necco Katelyn , Rath Thomas , Esfandiarei Mitra , Darban Nathaniel
Published: February 2024

Introduction: Cardiopulmonary bypass is an essential component of cardiothoracic surgeries. However, significant complications such as systemic inflammatory response syndrome (SIRS) resulting from cardiopulmonary bypass (CPB) are a common occurrence due to contact between circulating blood and foreign surfaces that leads to platelet activation. It is suggested that different available CPB circuit coatings can potentially reduce platelet activation. However, there have been no published evidence-based reports confirming these claims. In addition, there is no well-established protocol for studying platelet activation biomarkers during CPBin vitroin a laboratory setting.Methods: CPB was simulated in the laboratory using bovine blood in two different types of coated CPB circuits:Trillium®Biosurfaceby Medtronic, andXcoatingTMSurface by Terumo. Fresh bovine blood samples were collected and circulated through the CPB circuit following the standard protocol used in the operation rooms. Blood samples were then collected at 5 min, 30 min, and 55 min during the circulation. Blood plasmas were separated and subjected to enzyme-linked immunosorbent assay to measure most established platelet activation markers P-selectin, Platelet Factor 4 (PF4), Glycoprotein IIb/IIIa (GPIIb/IIIa), and β-thromboglobulin (β-TG) at different time points.Results: The biomarker values at 30 min and 55 min were compared to the base values at 5 min for each type of CPB circuit. The results of the means from all measured biomarkers showed data measurements that indicated no significant variability within each coating. All collected data points fell within ±2 SD of the means, which was considered acceptable variations across technical replicates. Conclusion: In this study, we were able to establish anin vitroprotocol in the laboratory setting that is precise and reliable with minimum intra-variability. This established protocol will allow for future studies in which different coated CPB circuits can be compared for their effectiveness in blocking platelet activation during the CPB.
Transformation of inclusions in S32101 duplex stainless steel during continuous casting
Authors: Chen Xingrun , Cheng Guoguang , Guo Jing , Pan Jixiang
Published: February 2024

In this study, the formation and characteristics of inclusions in S32101 duplex stainless steel (DSS) during continuous casting were investigated by analyzing inclusions in the tundish and continuous casting slabs. The composition of inclusions changed significantly during the continuous casting. The inclusion type in the tundish was primarily CaO-SiO2-Al2O3-MgO-MnO. There are two types of inclusions in the continuous casting slab: CaO-SiO2-Al2O3-MgO-MnO inclusions with dense Al2O3 and MnO, and Al2O3-MnO inclusions. TiN wraps the outer layers of both types of inclusions. The results obtained from thermodynamic calculations agreed with the experimental results. The weight percentage of Al2O3 and MnO in the inclusions increases significantly with the solidification process. In addition, the Al2O3-MnO inclusions were formed in the slab. TiN precipitates during the solidification of the S32101 DSS. The CaO-SiO2-Al2O3-MgO-MnO and Al2O3-MnO inclusions can be used as the nucleation sites of TiN.
Infusionswärmer zur Hämotherapie in der
Notfallmedizin: Ist die schnelle Gabe gewärmter Blutprodukte
prähospital möglich?
Authors: Rudolph Marcus , Knapp Jürgen , Sitzmann Nicole , Braun Jörg , Reifferscheid Florian
Published: February 2024

Im hämorrhagischen Schock erfolgt die zielgerichtete Therapie durch die
schnelle Transfusion von Blutprodukten. Diese sollten erwärmt appliziert
werden, um eine Hypothermie mit Koagulopathie zu verhindern. Hierzu,
müssen geeignete Maßnahmen ergriffen werden.

Die folgende Arbeit untersucht die Eignung handelsüblicher mobiler
Blutwärmer für die präklinische Transfusion.
Blutwärmer mit einem Wärmemodul reduzieren die Durchflussrate
und sind somit nur eingeschränkt für eine Notfalltransfusion
geeignet. Die Auswahl eines geeigneten Wärmegeräts spielt somit
eine wichtige Rolle für eine schnelle Applikation im Notfall.
Der kontinuierliche Verbesserungsprozess – Qualitätsmanagement in der Praxis
Authors: Arens Isabel
Published: February 2024

Verbesserungen ohne Veränderungen? Das ist kaum möglich. Viele Menschen sind allerdings Veränderungen gegenüber skeptisch. Sie wünschen sich zwar Verbesserungen, lehnen aber die dafür notwendigen Veränderungen von Verhaltensweisen, Abläufen und anderem ab. Dabei gibt es eine wunderbare Methode, sich stetig weiterzuentwickeln.
Neurologische Symptomatik bei post covid – Diagnostik und Therapie neurologischer Leitsymptome
Authors: Filipovic Silke , Klose Maike
Published: February 2024

Die Symptomatik beim Post-Covid-Syndrom ist breitgefächert. Neben den typischen Atembeschwerden zeigen sich muskuläre, neuropathische, kognitive oder vegetative Störungen sowie das Chronische Fatigue-Syndrom. Silke Filipovic und Maike Klose erklären die Symptomvielfalt anhand von Anatomie und Physiologie. Für das Erkennen der Leitsymptomatik helfen eine fundierte Anamnese sowie einfache Tests und Assessments. Die Rehabilitation fokussiert patientenspezifische Defizite.
Sport und Atemwegserkrankungen – Return to Sport nach Virusinfekten
Authors: Latsch Joachim , Grabe Miriam
Published: February 2024

Für Sportlerinnen und Sportler mit Atemwegserkrankungen gab es schon immer unterschiedliche Empfehlungen – die Coronapandemie hat die Sachlage nicht gerade vereinfacht. Unsere Autoren helfen Ihnen, die richtigen Entscheidungen zu treffen, wenn Sie Sportlerinnen und Sportler mit Atemwegserkrankungen betreuen.
Das wichtigste Kommunikationsmittel pflegen – Stimmhygiene im therapeutischen Alltag
Authors: Wunderlich Sabrina
Published: February 2024

Wir nutzen sie täglich von früh bis spät: die Stimme. Und wie in vielen anderen Bereichen auch kümmern wir uns erst um sie, wenn es zu Problemen kommt. Heiserkeit, dauerndes Räuspern oder ein dicker Kloß im Hals – typische Symptome von Therapierenden. Das muss nicht sein. In diesem Artikel erklärt Sabrina Wunderlich, wieso Prävention für die Stimme wichtig ist und wie sie ohne großen Aufwand in den therapeutischen Alltag integrierbar ist.
Promotional language in radiology publications: increasing use of “excellent”, “favorable”, “promising”, “robust”, and “unique”
Authors: Kwee Thomas Christian , Kwee Robert Michael
Published: February 2024

Purpose To investigate if radiology researchers are increasingly promoting their scientific findings by more frequently using positive words in their publications.

Materials and Methods This study included all articles that were published in 14 general radiology journals between 2003 and 2022. The title and abstract of each article were assessed for the presence of positive, negative, neutral, and random words, according to predefined sets of words for each category. Usage of positive, negative, neutral, and random words was calculated for each year and corrected for the total number of articles in each year. Temporal trends between 2002 and 2023 and the relationship between positive word usage and journal impact factor (IF) were assessed.

Results Positive word usage (Mann-Kendall tau of 0.895, P< 0.001) and neutral word usage (Mann-Kendall tau of 0.463, P = 0.005) showed significant upward temporal trends. Negative word usage and random word usage did not show any significant temporal trends. Five positive words showed significantly increased usage over time and were present in more than 1 % of titles/abstracts in at least one year: “excellent” (Mann-Kendall tau of 0.800, P< 0.001), “favorable” (Mann-Kendall tau of 0.547, P< 0.001), “promising” (Mann-Kendall tau of 0.607, P< 0.001), “robust” (Mann-Kendall tau of 0.737, P< 0.001), and “unique” (Mann-Kendall tau of 0.747, P< 0.001). There was no significant association between positive word usage and journal IF.

Conclusion Radiology researchers appear to increasingly promote their scientific findings by more frequently using positive words in their publications over the past two decades.

Key Points 

Citation Format
Chronische Schmerzen im Alter – psychologische Aspekte und
ihre therapeutischen Konsequenzen*
Authors: Mattenklodt Peter , Ingenhorst Anne , Flatau Brigitta , Grießinger Norbert
Published: February 2024

Chronische Schmerzen im Alter gehen mit gravierenden gesundheitlichen
Auswirkungen einher. Internationale Leitlinien fordern daher, dass die
Schmerztherapie Älterer bevorzugt als interdisziplinäre
multimodale Therapie auf der Basis eines bio-psycho-sozialen Schmerzmodells
erfolgen sollte. Für das interdisziplinäre Schmerzassessment
liegen spezifische Testverfahren und Interviewleitfäden vor. Die Evidenz
für die Wirksamkeit einer interdisziplinären multimodalen
Schmerztherapie bei Älteren ist noch begrenzt. Kontrollierte klinische
Studien konnten zeigen, dass diese Patienten von einer solchen Therapie
profitieren – insbesondere, wenn die Therapie an ihre spezifischen
Bedürfnisse angepasst wird. Im psychologischen Training sind
insbesondere Schmerzakzeptanz, Balancierung von Ruhe und Aktivität,
soziale Integration und der Umgang mit dem Älterwerden wichtige Themen.
Auch Entspannungs- und Achtsamkeitsverfahren können die Schmerzen und
die Funktion günstig beeinflussen, sind bei Patienten beliebt und werden
oft in das alltägliche Schmerzmanagement übernommen.
Schmerzedukation als begleitende Maßnahme gilt als sinnvoll und kann
auch bei Älteren zunehmend durch digitale Medien unterstützt
werden. Zur Reduzierung von Angst-Vermeidungs-Überzeugungen empfiehlt
sich ein konfrontationstherapeutisches Vorgehen nach den Prinzipien einer
Angsttherapie („AMIKA“). Da unklar ist, wie lange die erreichten
therapeutischen Effekte anhalten, kommt der Nachsorge bei der Therapie
älterer Patienten besondere Bedeutung zu.
Sexualbezogene Online-Fortbildung für Fachkräfte: Instagram
Authors: Döring Nicola
Published: February 2024

Der vorliegende Praxisbeitrag befasst sich mit der Foto- und Video-basierten Social-Media-Plattform
Instagram. Er beschreibt die Funktionsweise der Plattform und geht auf den bisherigen Stand der
Instagram-Forschung ein. Ist Instagram eher sexistisch oder feministisch? Wirkt die Plattform eher
aufklärend oder desinformierend? Die Betrachtung der Instagram-Repräsentation ausgewählter
sexualbezogener Themen wie Körperbild, Menstruation, Verhütung und LGBTIQ + zeigt ein ambivalentes Bild.
Fachkräfte können dazu beitragen, dass Instagram eine hilfreiche Ressource für sexuelle und reproduktive
Gesundheit und Rechte darstellt.
Looking beyond in Sleep Medicine Practice: Effect of OSA Management in Floppy Eyelid Syndrome – A Case Report
Authors: Bolouki-Azari Helya , Soleimani Arman , Najafi Arezu , Amirifard Hamed
Published: February 2024

Obstructive Sleep Apnea Syndrome (OSA) is a common sleep disorder characterized by recurrent episodes of partial or complete upper airway obstruction during sleep. Floppy Eye Syndrome (FES) is a condition in which the upper eyelids easily evert with upward traction due to underlying tarsal plate laxity and is associated with chronic, reactive papillary conjunctivitis; this causes the eye to be vulnerable to discomfort and visual symptoms. A 49-year-old man with an 8-year history of snoring, sleep fragmentation, and daytime sleepiness was admitted as an outpatient in our sleep clinic. The patient had complied ocular symptoms such as burning eyes, redness, and irritative ocular symptoms in the past five years, arising upon waking up. The symptoms did not regress with the use of artificial tears and proper ointment. The patient was diagnosed with OSA and began using continuous positive airway pressure (CPAP). CPAP therapy significantly corrected the symptoms of FES associated with OSA . This would help to sensibilize ocular findings in patients with OSA and identify hidden sleeping diseases needing a more appropriate investigation and possible treatment. We must look beyond our approach to sleep clinic patients and avoid being kept to the common symptoms patients represent.
Association between Sleep Problems and Psychopathologies among Preschoolers: A Brazilian Cross-Sectional Study
Authors: Rafihi-Ferreira Renatha El , Alckmin-Carvalho Felipe , Rocha Marina Monzani da , Campoli Thiago Soares , Ollendick Thomas Hubert
Published: February 2024

Objective To evaluate the relationship between sleep problems and psychopathologies in Brazilian preschool children.

Materials and Methods The present is a cross-sectional study with162 children: 81 with sleep problems referred for treatment (mean age: 3.67 years), matched by gender/age with 81 participants without sleep problems. Sleep problems were identified through a clinical interview with a specialist. Psychopathologies were evaluated using the Child Behavior Checklist for Ages 1.5-5 (CBCL/1.5-5).

Results Having sleep problems was a predictor of all forms of psychopathologies on the CBCL scales, except for the withdrawn scale. Aggressive behavior, depression/anxiety, affective problems, and oppositional defiant disorder were associated with presence of sleep problems.

Conclusion Given the probable bidirectionality of the association between sleep problems and psychopathologies in children, it is suggested that regular assessments of both phenomena should be performed in children referred for treatment of sleep problems and mental health problems in general.
Transformation of Human Split Thickness Skin Auto-Graft
Authors: Vashi M. D. , Roy M.
Published: February 2024

This work is carried outto study the transformation of human split thickness skin auto–graft of various age group.

Split skin graft between 3 wesks to 3 years have been studied clinically from the point of view of its colour, texture, sensations and sweating. Simultaneously the pieces of respective grafts were taken to examine the histological changes in epidermis and dermis. Both clinical and histologcal features of respective grafts are noted to study the transformation of the Graft.

Three years old split skin autograft almost simulates normal skin in the matter of colour in fair complexioned individuals, textures, and sensations. It does not grow hair and there is no sweating.
Electrical Excitability of the Facial Muscles in Cleft Lip & Palate Cases
Authors: Bhatnagar S. K. , Chandra R. , Sharma R. N. , Dayal B.
Published: February 2024

The present study show that the excitability of the orbicularis oris muscle on the cleft side was low as compared to the non cleft side, and as deformity was increasing from group 1-1/3 to group II a higher intensity of current was required to get minimal muscular contraction.
Oculoauricular vertebral dysplasia (Goldenhar's Syndrome)
Authors: Chari P. S.
Published: February 2024

A case of Goldenhar's Syndrome with the unusual feature of 2 colobomas of the same upper eyelid is presented. The embryological basis of the complex anomalies is discussed. A selected bibliography is included.
Hearing Loss in Patients of Cleft LIP and Palate
Authors: Gupta I. J. , Sharma R. N. , Bhatnagar S. K. , Bhatia N. , Somasundran N.
Published: February 2024

This study showing 65 percent hearing loss in cases of cleft lip and/or palate cases.
Congenital Double Upper Lip: A Case Report
Authors: Bhattacharya Dr. V. , Tripathi Dr. F. M. , Sinha Dr. J. K.
Published: February 2024

An uncommon case of congenital double upper lip and its treatment is presented.
Midline Forehead Flap Rhinoplasty in Patients With Low Hairline
Authors: Acharyya LT COL S.K.
Published: February 2024

The classicel midline forehead flep rhinoplasty is an ideal procedure for reconstruction of full thickness defect of the lower part of the nose. But the surgeon may be handicapped in 2 patient with a low hairline. A modified procedure is described in which the forehead flap is caterpillared to obviate this difficulty.
Relay Grafting of Skin
Authors: Sinha Prof. R. C. , Sinha Dr. Bipin B.
Published: February 2024

1. 12 cases in whch skin grafting had been done for varied reasons were taken up for study of relay grafting.

2. Procedure of the taking and application of the relay graft was followed as layed down by Smahel (1972).

3. Raw areas varying from 1“ to 2½“ were covered by means of relay graft. There was complete take of the graft in 58.8%, partial take in 33.3% and complete rejection in 8.4% of the cases.
A Rare Congenital Hand Tumour
Authors: Bhattacharya Dr. V. , Sinha Dr. J. K. , Tripathi Dr. F. M. , Khanna Dr. Mrs. S.
Published: February 2024

A case of rare congenital hand tumour is presented.
Antimicrobial Effect of Aminotic Membrane (A study of 100 cases)
Authors: Yadav Dr. R. G. , Sadasukhi Dr. T. C. , Chandalia Dr. B. S.
Published: February 2024

In this study most of the infected wounds dressed with amniotic membrane showed marked reduction in bacterial counts within 25 days (96%) as compared to control group of patients who's wound required 36 days or more for similar result. However more work should be done on this subject for further evolution.
Chemotherapy For Advanced Oral Cancer
Authors: Khanna N. N. , Khanna A. , Pant G. C. , Sanyal B. , Khanna S.
Published: February 2024

A combination of three drugs, cyclophosphamide, methotrexate and 5-Fluorouracil was tried in 50 consecutive cases of advanced oral cancer. The overall response rate was 66%, and the incidence of toxicity 18%. The response was better in primary cases as compared to those who had received prior radiotherapy. However the response was shortlived.
Flap Lacerations With Distal Base (A Study of Coal Mining Injuries)
Authors: Rao Dr. Y. Poornachandra
Published: February 2024

1. A total number of 55 cases ol distally based flap lacerations in coal miners are reported.

2. Fap lacerations in thigh and arm behave in a way similar to extensive lacerations elsewhere in the body.

3. Flap lacerations overlying the tibia, more so in the distal 1/3rd are predestined to poor healing compared to their counterparts over the calf.

4. Primary suture of flap lacerations is to be avoided and delayed primary suturing is preferable.

5. Steristrip application may be justified in these cases to prevent wrinkling of the flap.

6. Enforced bed rest, Elevation of the limb, early regular inspection of the wound and compression/supportive bandages form an essential part of the treatment.
“Basal Cell Carcinoma And Reconstructive Surgery” (A Study of 150 Cases)
Authors: Yadav Dr. R. G. , Chandalia Dr. B. S.
Published: February 2024

An analysis of the 150 cases of basall cell carcinoma seen at plastic surgery department at Jaipur are reported. 112 cases were treated by surgery with a recurrence rate of 2-3% while radiotherapy had high recurrence rate of 20%, Surgery is better modality of treatment as it has got a much better cure rate.
Use Of Stored Srin Grafis In Resurfacing Of Wounds (An experience of 100 cases)
Authors: Sharma Lt Col J. C.
Published: February 2024

Stored split thickness skin grafts were for resurfacing wounds of various types in 100 cases, The grafts were applied in the ward after 24-58 hours delay and were treated by exposure method. The advantages claimed are a better take of the graft, reduced blood loss, and less operation time, economy in dressing and participation of ward staff in the management of these cases.
Extensor Digitorum Brevis In Hand
Authors: Garg K. , Bahl I.
Published: February 2024

Two cases of the presence of Extensor digitorum brevis in hand are presented.

Cadaver No, 1—During routine dissection the tendon of Extensor indicis was absent from its normal position in the fourth compartment under the extensor retinaculum of Instead one fleshy belly was seen on The origin of hand. the dorsum of both hands, the belly was aponeurotic from dorsal radiocarpal and intercarpal ligaments. The fleshy belly gradually became tendinous and was seen to pass along the medial side of Extensor digitorum tendon for the index finger, forming the extensor expansion. The muscle was bigger in the right hand (Fig. 1). The nerve supply was from terminal part of deep branch of radial nerve.

Cadaver No. 2-One fleshy belly was seen on the dorsum of hand, supplementing the tendon of Extensor digitorum for the middle finger. 1t was present only in the left hand. The origin of the muscle was aponeurotic from radiocarpal and intercarpal ligaments. The muscle was crossed superficiallp by the tendon of Extensor indicis. The fleshy belly became tendinous to join Extensor digitorum for the middle finger from its lateral side. The nerve supply came from terminal part of deep branch of radial nerve (Fig. 2).
Primary Central Salivary Adeno-Carcinoma Of Mandible
Authors: Dr Wadkar M. A. M. , Dr Gupta A. K. , Dr Sharmo L. K. , Dr Sharma S. V.
Published: February 2024

A case of primary central adenocarcinoma of mandible is reported. Rib graft was put to rehabilitate the patient after a recurrence free interval of 6 months. No adjuvant chemotherapy or radiotheraphy was started in our patient.
Experience With Vaso-Vasostomy: Technique And Result
Authors: Singh P. B. , Kumar Hemant , Ambasta S. S. , Tripathi V. N.P.
Published: February 2024

Fifteen patients underwent recanalization procedure by single layer non magnified anastomosis with splint. In 12 patients (807%) reappearance of sperm was found with sperm count ranging from 5-6/H.P.F. to 40 million/ml. No side effect was observed due to splint.
The History of Diagnosing Venous Thromboembolism
Authors: Martens Emily S.L. , Huisman Menno V. , van Mens Thijs E. , Klok Frederikus A.
Published: February 2024

An accurate and prompt diagnosis of deep vein thrombosis and/or pulmonary embolism is important to prevent serious complications and mortality. Because the clinical presentation of venous thromboembolism (VTE) is often nonspecific, objective testing by means of radiological imaging is required to confirm the diagnosis. Historically, a diagnosis of VTE involved invasive imaging techniques like contrast venography or conventional pulmonary angiography. Technological developments toward more accurate and less invasive diagnostics have driven the implementation of a variety of newer technologies over the past decades, as well as the derivation and validation of clinical decision rules (CDRs) that can be used to rule out VTE in combination with D-dimer blood tests. In this narrative review, we provide a historical overview of the most notable developments in the imaging techniques and CDRs for VTE diagnosis.