bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitik Tasavvurun Siyer Kültürüne Etkileri: Muîniddin el-Miskin’in Meâricü’n Nübüvve fi Medârici’l Fütüvve’si Örneği
Authors: ARSLAN Mustafa
Published: June 2018

Bu makalede Muînüddîn el-Miskîn’in (ö. 907/1501)

Meâricü’n Nübüvve fi Medârici’l Fütüvve adlı siyer

eserindeki mitsel motifler incelenmiş, eserin Türkçe çevirisinde meşhuru olan

Altıparmak Mehmet’inki esas alınmıştır. Eser diğer siyer kitaplarından farklı olarak

Nûr-ı Muhammedî kavramını merkeze

almakta, sadece Hz. Muhammed’in hayatını konu edinmeyip kozmolojik konuları

mitik tarzda ele almaktadır. Yaratılış konusunun eserin başında mitik anlatımla

işlenmesi, Nûr ve diğer başka (kalem,

ağaç, kuş-ruh kuşu vb.) sembollerin kozmolojik konuların anlatımında

kullanılması esere mitik karakter kazandırmaktadır. Ancak bu mitik nitelik

sadece eserin başında değil, Nûr’un ele alındığı bölümlerde de (Miraç, Hz.

Peygamberin doğumu vb.) de kendisini göstermektedir. İslam geleneğindeki birçok

kavramın arketiplerine değinilmektedir. Eser Türk ve Mezopotamya

kültürlerindeki mitik etkiyi barındırması, evrenin varoluşu, yaratılış, doğuş,

ölüm gibi anlatımı zor kozmolojik konuları Hz. Muhammed (sav) merkezli ve mitik

söylem tarzıyla ele alışı kitlelerin esere olan ilgisini artırmıştır
Rus Ortodoksluğunu Protesto Etmenin İmkânı: Malakanlar/Manevi Hıristiyanlar
Authors: DUALI Şir Muhammed
Published: June 2018

Hıristiyanlık tarihi incelendiğinde hemen her

dönemde heretik addedilen onlarca akımın ortaya çıkmıştır. Özellikle on beşinci

yüzyıldan itibaren Katolisizm’e karşı Batıda birden fazla dini oluşumun

Protestanlık şemsiyesi altında gün yüzüne çıkmıştır. Bu husus, Ortodoks

Hıristiyan dünyasında da yankı bulmuş ve özellikle Çarlık Rusyası’nda kimi

ayrılıkçı hareketler belirmiştir. Bu çalışma, Ortodoksluğa bir protesto

mahiyetinde teşekkül eden Malakanizm hareketini konu edinmektedir. Bu çerçevede

ilk olarak Malakan inancının ortaya çıkışı, gelişimi, inanç ve ibadet esasları

araştırma konusu edinilmekte, Malakanizm ile Protestanlık arasında benzer ve

ayrışan noktalar üzerinde durulmaktadır. Ayrıca Malakanizm hareketinin

Protestanlık kadar başarı elde edemeyişinin nedenleri tespit edilmeye

çalışılmaktadır.
Yasin Meral, Sâmirî’nin Buzağısı
Authors: ALTINEL Tolga Savaş
Published: June 2018

Kur’an-ı Kerim kıssalar hususunda büyük oranda Kitab-ı Mukad-des’le ortak bir zemini paylaşmaktadır. Hz. Adem’in cennetten ko-vuluşu, Hz. Nuh’un tufanı, Hz. İbrahim’in oğlunu kurban etmeye çalışması, Hz. Musa’nın İsrailoğullarını Mısır’dan çıkarması veya Hz. İsa’nın doğumu her iki kutsal kitabın ele aldığı konulardır. An-cak farklı bir anlatım söz konusu olduğunda Kur’an-ı Kerim, tuhaf bir şekilde güvenirliliği tartışma konusu olan Kitab-ı Mukaddes’teki bilgiler kullanılarak eleştirilmektedir. Bunun yanında İslam gelene-ğinin Kur’an’ı Kerim’in sessiz kaldığı hususlarda kıssaları bir bütün olarak sunmak adına çoğu zaman Yahudi ve Hristiyan geleneğin-deki bilgileri kaynak göstermeden kullanması, Kitab-ı Mukaddes başta olmak üzere Yahudi ve Hristiyan kaynaklarının bu alanda mutlak otoriteye dönüşmesine katkıda bulunmuştur. Dolayısıyla Kur’an-ı Kerim, Kitab-ı Mukaddes’ten farklı bilgiler sunduğunda; ya teolojik bir şartlanma ile oryantalistler tarafından tarihsel (!) hata yapmakla suçlanmış ya da Kitab-ı Mukaddes’e tanınan bu mutlak otoritenin karşısında uzlaştırma yolu seçilerek bu farklılığın sebebi ve yol göstericiliği göz ardı edilmiştir. Hâlbuki Kur’an’ı ayrıcalıklı kılan şey, onun kıssalar hususunda Yahudi-Hıristiyan geleneğini yi-nelemenin ötesinde onun kalıplarının sorgulanmasını gerektiren tartışma başlıklarını belirlemesidir. İşte Yasin Meral’in Sâmirî’nin Buzağısı kitabı, Kur’an’ın farklı söylemleriyle Kitab-ı Mukaddes’teki bilgileri tartışmaya açan başlıklardan biri olan buzağı kıssasını ana-liz etmektedir. Yazar kendi ifadesiyle hocası Baki Adam’ın Yahudilik ve Hristiyanlık Açısından Kuran’ın Tartışmalı Konuları isimli eserinde açtığı yoldan ilerlemektedir. Öyle ki Meral, Sâmirî mevzusunu irde-lemekle Baki Adam’ın ele aldığı Hâmân, Üzeyir ve Meryem’e ilave-ten Kur’an’ın tartışmalı konuları arasına müstakil bir müzakere baş-lığı eklemiş bulunmaktadır
Mehmet Alıcı, Işığın Elçisi Mani ve Gnostik Düşüncesi
Authors: TOPRAK Bilal
Published: June 2018

İnsanın

kurtuluşunu hedefleyen dinlerin temel öğretilerini belirleyen etmenlerin

başında insanın madde ile olan ilişkisine yönelik konular gelmektedir. Kimi

dini gelenekler insanı bir bütün olarak ele alırken, kimileri de maddeyi

teolojik ve ontolojik açıdan kötü olarak değerlendirir. Dinin dünyaya bakışını

belirleyen, insan ve çevre ilişkilerine yön veren bu etkinin doğru

anlaşılabilmesi için gnostik geleneklerin insan algısı büyük önem arz

etmektedir. Düalist bir bakış açısına sahip olan gnostik düşünceye göre, madde

ve maddeden kaynaklanan her şey kötüdür. Maddeye karşı geliştirilen bu radikal

tavrın sonucu olarak, Tanrı’nın kötü olan hiçbir şeyi yaratmayacağı düşüncesi

hâkimdir. Kötü bir yer olan dünyada, dünyevi işler aracılığıyla kurtuluşa ermek

mümkün değildir. Buna göre gerçek kurtuluş ancak hakikatin bilgisine yani gnosise

sahip olmakla mümkün olabilir. Birçok dini cemaat sayesinde varlığını sürdüren

gnostisizm, özellikle Sabiilik ve Maniheizm sayesinde müstakil bir yapıya

bürünür. Bu bağlamda kendisini Budda, Zerdüşt ve İsa Mesih’in müjdelediği

kurtarıcı olarak tanıtan Mani’nin gnostik yaşam öyküsü ve düşüncesi

Ortadoğu’daki dini grupları anlamak noktasında da bizlere önemli ipuçları

sunmaktadır. 
In vitro transcription of S. pyogenes Cas9 sgRNAs from two complementary oligos v1
Authors: Floor Stephen
Published: June 2018

A protocol to in vitro transcribe sgRNAs from oligos for S. pyogenes Cas9.
NCT03171688 - clinical protocol (PT-BR) v1
Authors: Magalhães Nunes Guimarães Gabriel
Published: June 2018

A single prospective cohort of women submitted to cesarean section who received spinal anesthesia will be assessed for the proposed risk factors and the incidence of nausea or vomiting will be observed during the first 48 hours.
Çam kese böceği (Thaumetopoea wilkinsoni Tams) zararının kızılçam (Pinus brutia Ten.) büyümesi üzerinde olan etkisinin beş yıllık sonuçları
Authors: ERKAN Neşat
Published: June 2018

Çam
kese böceği (Thaumetopoea wilkinsoni Tams.) ülkemizde
çoğunlukla Akdeniz Bölgesinde ve özellikle kızılçamda, zaman zaman da sedir ve
karaçam gibi diğer ibreli ormanlarda larva döneminde ağaçların ibrelerini
yiyerek zarar yapmaktadır. Geçici süreliğine de olsa üretim organlarını
kaybeden ağaçların büyüme faaliyetleri olumsuz etkilenmektedir. Diğer
yandan böcek zararı, ibrelerin bir yıldan daha uzun sürede yenilenmesi
nedeniyle ağaçların büyümesi üzerinde sadece cari yılda değil, daha sonraki
yıllarda da etkili olabilmektedir. Yine zararın etkisi, böcek zararının sadece
bir yıl veya devam eden yıllarda da olup olmamasına göre önemli ölçüde
değişebilmektedir. Bu çalışmada çam kese böceğinin kızılçam büyümesi üzerine
cari yıldaki ve cari yılı aşan etkisinin ortaya konulması amaçlanmıştır. Çalışma,
Antalya yöresinde iki farklı deneme alanında 5 yıl boyunca yürütülmüştür. Başlangıçta
böcek zararı sonucu % 40 ve üzeri oranda yaprak kaybına uğrayan ağaçlar
işaretlenmiş, daha sonraki yıllardaki yaprak kaybı durumları da izlenerek, eklemeli
toplam yaprak kaybı ölçülmüştür. Yine yaprak kaybına uğrayan bu ağaçların,
kontrol ağaçlarına kıyasla beş yıllık süre içinde toplam çap ve hacim büyümesi
kaybı hesaplanmıştır. Çalışma sonucunda beş yıllık eklemeli toplam yaprak kayıp
oranı ile toplam çap ve hacim büyüme kaybı arasında anlamlı ilişki tespit
edilmiş olup, bu ilişkiyi yansıtan doğrusal regresyon denklemleri ortaya
konmuştur. Ayrıca ağaçlardaki yine beş yıllık toplam kese adedi ile yaprak
kayıp oranı arasındaki ilişki incelenmiş, ancak bu ilişkinin iki deneme alanı
için de anlamlı olmadığı ortaya konmuştur.
Associaton between violence and drug consumption with suicide in lesbians, gays, bisexuals, transvestites, and transsexuals: cross-sectional study
Authors: Albuquerque Grayce Alencar ,   Universidade Regional e Cariri, Ceará, Brasil., dos Santos Figueiredo Francisco Winter , da Silva Paiva Laércio , Moura de Araújo Márcio Flávio , da Silva Maciel Erika , Adami Fernando ,   Faculdade de Medicina do ABC, Santo André, Brasil.,   Universidade da Intergração Internacional da Lusofonia Afro-Brasileira, Redenção, Brasil.,   Centro Universitario Lutherano de Palmas, Palmas, Brasil.
Published: June 2018

Introduction. Lesbian, gay, bisexual, transvestite, and transgender (LGBT) people are affected by prejudice and psychological, physical, and/or sexual violence due to their sexual orientation. Objective. To analyze the association between violence, drug use, and suicide in LGBT people. Method. We interviewed 316 LGBT people from two cities of the Brazilian Northeast by means of a structured instrument. This included questions about sociodemographic data, sexual orientation, type of violence, type and quantity of drugs consumed, and suicide. Results. There was a positive association between physical violence and anabolic consumption (p = .001) and tranquilizers (p = .012). In relation to psychological and verbal violence, there was a positive association with the use of tranquilizers (p = .021) and negative with the use of amphetamines (p = .027). Suicide attempts were associated with having experienced physical (p = .03) and sexual (p = .037) violence. Drug use, especially ecstasy, cocaine, marijuana, and tranquilizers, was also associated with suicide attempts (p = .002, p = .031, p < .001, p < .001, respectively). The participants who had already attempted suicide were more vulnerable to experience violence and consume drugs within 30 days prior to the interview (p < .001). Discussion and conclusion. Psychological/verbal violence showed to be associated with the use of amphetamines, while physical violence was associated with a higher consumption of tranquilizers and anabolic steroids. Suicide attempts were more common among participants who had suffered physical violence and who were users of substances such as ecstasy, cocaine, marijuana, and tranquilizers.
Characterization of the Mu rhythm during the sleep of children with autism spectrum disorder level 1
Authors: García Vite Tania Karina ,   Laboratorio de Neurociencias, Facultad de Psicología, Universidad Nacional Autónoma de México, Ciudad de México, México., Ayala Guerrero Fructuoso , Mateos Salgado Erik Leonardo , Cebreros Paniagua Rodolfo
Published: June 2018

Introduction. Autistic spectrum disorder (ASD) is characterized by difficulties in communication and social interaction. The theory of mind (TM) links social deficiencies in ASD with a difficulty in representing the mental states of other people. The Mu rhythm (8-13Hz) has been studied as an expression of the possible neuronal basis of TM. In ASD, the physiological reactivity of the Mu rhythm to motor events is affected. During sleep, there are also phenomena related to sensorimotor processing. Objective. To characterize the Mu rhythm in the sleep of children with level 1 ASD, ages six to 10, and compare it with control children paired by age and sex. Method. Polysomnographic records for two consecutive nights. The record of the second night was analyzed visually (the first was considered habituation) to identify and select Mu rhythm segments throughout the night. The extracted segments were analyzed using the fast Fourier transform and subsequently with t tests on the data of C3 and C4. Results. A significant difference was found in the power spectrums of C3 and C4 t (1, 144) = 3.038, p = .003 and t (1, 144) = -2.301, p = .023, respectively. Discussion and conclusion. The results of this study are consistent with the morphological and topographic characteristics found in studies conducted during wakefulness. The results suggest that the Mu rhythm is caused intrinsically, without external sensory stimulation, and that there is a difference in this generation in the population with ASD.
Comparing Timeline Rhythms in Pygmy and Bushmen Music
Authors: Poole Adrian
Published: June 2018

Combining theories of African rhythm from ethno/musicology and findings from anthropological research and population genetics with musical analyses based on transcriptions and computational phylogenetic techniques, this article compares rhythms used in Pygmy and Bushmen music in an attempt to provide new perspectives on an old debate that these musical cultures may share a common heritage. To do this, the comparative analyses focus on timelines: foundational rhythmic features that provide the structural basis of the music. The findings suggest that Pygmy and Bushmen timelines are interrelated and that most are organised according to the principles of 'rhythmic oddity' and maximal evenness. Generative theory suggests that commonly used rhythmic cells, in particular the 3:2 pattern, form the structural basis of many Pygmy/Bushmen timelines as well as many other timelines featured in African and African-derived musics. Timelines are also multi-purpose musical devices used in various different social contexts and their structure appears to be resilient to radical change. Phylogenetic analysis of timelines provides no clear Pygmy/Bushmen ancestral timeline, although it is possible that foundational rhythms such as the 3:2 pattern may have featured in the music of a common ancestral group.
Commentary on "An Exploratory Study of Western Orchestration: Patterns through History" by S.H. Chon, D. Huron, & D. DeVlieger
Authors: Reuter Christoph
Published: June 2018

This commentary discusses the exploratory study by Chon, Huron and DeVlieger about the usage and combinations of musical instruments in orchestral works between 1700 and 2000 under the perspective of the evolution of the musical instruments in that time, their acoustical and social aspects as well as recommendations in orchestration treatises of the last 300 years.
Commentary on Neumann's "Phenomena, Poiēsis, and Performance Profiling: Temporal-Textual Emphasis and Creative Analysis in Turandot at the Metropolitan Opera"
Authors: Barolsky Daniel
Published: June 2018

This commentary situates Neumann's research within the existing literature on musicological ontologies of the musical work as well as scholarship on the analysis of performance and recordings. The response focuses on the interdisciplinary strength of the author's method while offering a few caveats about the analytical tools used. Although Neumann ventures into an under-explored territory (i.e. the analysis of operatic voices), I urge the author not to isolate this analysis from other elements of performance, including both visual content and listening experience
Analogy, Homology, and Rhythmic Phylogeny: Commentary on Adrian Poole's "Comparing Timeline Rhythms in Pygmy and Bushmen Music"
Authors: London Justin
Published: June 2018

In his article "Comparing Timeline Rhythms in Pygmy and Bushmen Music," Adrian Poole uses computational phylogenetic analysis to assess the similarity between canonical rhythmic patterns from two African musical cultures. He then uses these analyses to evaluate previous claims of a common origin for their (now) distinct musical practices. Poole was unable to find clear evidence of a common origin, and here I provide additional analyses of these timelines casting further doubt on such claims. Instead, I offer a perspective from convergent evolution/sociobiology which can account for the broad similarities that exist between these two sets of timelines. I conclude with a critique of the claim of Poole and others that African timelines and the musical cultures in which they appear are especially resistant to change.
The Development Trend of Modern Technology of Electronic Engineering
Authors: Liu Tong , Cao Zhijun , Cheng Liang , Liu Yanfeng , Zhang Haipeng
Published: June 2018

With the rapid development of science and technology in China, a large number of scientific and modern technologies have been developed and widely used. Among these technologies, electronic engineering technology has received great attention in many domestic industries and has been widely applied. Over the years, the technology of electronic engineering modernization not only is very common in many large-scale projects, but also in the production of household appliances facilities and intelligent integration of manufacturing facilities has a universal application. As one of the modern technologies, electronic engineering technology and modern society People's Daily life and work are closely related. According to the research achievements in this field over the years, the article focuses on analyzing the trend of the development of modern electronic engineering technology, to make contribution to further with the research and application of this technology.
Problems and Countermeasures in Construction Quality Management of House Building Engineering
Authors: Song Cuigang , Liu Yang , Zhou Changqing , Wen Long , Zhao Yunfei
Published: June 2018

As one of the main types of construction projects in China, the goal of the construction of buildings is providing people with a good and safe living and working space. The significance of construction quality management is also self-evident. At the same time, the effective implementation of construction quality management of housing construction projects has a very realistic impact on the construction enterprises themselves. Therefore, building enterprises should actively study the improvement and optimization of construction quality management.
Analysis of Application of Environmental Engineering Construction in Ecological City
Authors: Sun Shutian , Huang Kunxue , Hu Yu , Xing Zhixin , Su Qingjiang
Published: June 2018

At present, with the continuous deterioration of the ecological environment and the gradual deepening of human understanding of the relationship between man and nature, the construction of an ecological city has become the trend and inevitable urban construction in the future. Finding harmonious development among cities, human beings, and the natural environment through the construction of the ecological environment is an inevitable choice for human and urban development. In order to provide sufficient theoretical exploration for the construction of ecological cities, this paper first introduced the two important concepts of ecological environment and environmental engineering and the necessity of ecological construction. On the basis of this, it analyzes the various obstacles and predicaments in the current construction of ecological cities and achieves the purpose of clarifying the problems; finally, it proposes corresponding countermeasures[1].
Maternal and neonatal characteristics of babies admitted with congenital CNS anomalies in a tertiary hospital in North Central Nigeria
Authors: Diala Udochukwu Michael , Toma Bose Ozoiza , Shilong Danaan , Shwe David Danjuma , Bot Gyang Markus , Ofakunrin Akinyemi David , Binitie Peter
Published: June 2018

Background: CNS anomalies are an important group of largely preventable congenital anomalies. Knowledge of maternal and neonatal sociodemographic characteristics could identify a pattern of population at risk in order to target preventive interventions.Methods: This was a 3-year retrospective review of health records of all neonates admitted with CNS anomalies in Jos University Teaching Hospital (JUTH), Jos, central-Nigeria.Results: Out of a total of 27 neonates with congenital CNS anomalies reviewed, 25 had neural tube defects, 1 hydrocephalos and 1 anencephaly. The peak age group of mothers were 20-29years (44.4%) and 30-39 years (44.4%). Twenty-two (81.5%) mothers had antenatal care (ANC). No mother booked in the 1st month and only 7 (25.9%) booked in the first trimester. Twenty-four (88.9%) mothers took folic acid during pregnancy. No mother had peri-conceptional folic acid use. There were 11(40.7%) home births with 14(87.5%) of the 16 hospital births taking place in lower tier health facilities. Twenty-six (96.3%) mothers had vaginal delivery. An obstetric ultrasound scan was reported by one (3.7%) mother and did not detect the anomaly. Five (18.5%) of the mothers had HIV infection. Twenty-six were term with a male: female ratio of 1.1:1. The median age at presentation was 2 (interquartile range 1, 8) days.Conclusions: Neonates with congenital CNS anomalies in JUTH frequently had mothers aged <35 years who did not receive preventive care before and during delivery. We therefore recommend interventions to improve the efficiency of health care delivery to cater for this gap.
Evaluation of smartphone addiction and related factors among university students
Authors: Akbulut Zencirci Sevil , Aygar Hatice , Göktaş Saniye , Önsüz Muhammed Fatih , Alaiye Melike , Metintaş Selma
Published: June 2018

Background: The purpose of this study is to investigate the level of smartphone addiction of university students and determine the related factors.Methods: This cross-sectional study was conducted among first and third-class students of the 2016 fall semester in Eskişehir Osmangazi University with 1492 students. In this study, risk of smartphone addiction was evaluated by using Short Version of Smartphone Addiction Scale (SAS-SV). In data analysis, Mann Whitney U, Kruskal Wallis and hierarchical multi linear regression analysis were executed.Results: 772 (51.7 %) of 1492 students in the study group was female. SAS-SV median score of the students was 26. In this study; gender, socio-economic level, perceived health status and mostly used smartphone function were specified as factors influencing smartphone addiction. While, using smartphone for functions such as social media, gaming, online messaging and video watching was assigned to be positively related with smartphone addiction; using smartphone for telephone calls, e-mail and news reading was assigned to be negatively related. 71.2% of students (n:1063) declared to have health problems related with using smartphones. Insomnia was revealed as the most common (23.6 %) health complaint related to smartphone use.Conclusions: Social contact and applications with entertaining contents in smartphone enhance addiction. There is need for more studies and researches for exerting smartphone addiction, related factors and applying necessary protective and therapeutic interventions.
Resolving blood group discrepancy in patients of tertiary care centre in Odisha, India
Authors: Mishra Debasish , Parida Pankaj , Mahapatra Smita , Sahoo Binay Bhusan
Published: June 2018

Background: Blood grouping consists of both forward grouping; reverse grouping and both procedures should agree with each other.A blood group discrepancy exists when results of red cell testing do not agree with serum testing, usually due to unexpected negative or positive results in either forward or reverse typing. ABO and Rh blood group discrepancy is associated with incompatible transfusion reaction.Blood group discrepancy should be resolved before transfusion and blood group to be properly labeled to prevent transfusion reaction.Methods: A prospective study was carried in SCB blood bank which is under the Department of Transfusion Medicine, SCB Medical College and Hospital, Cuttack, Odisha from January 2015 to October-2016. Total 25,559 blood samples of patients were included in the study and hemolysed samples excluded. The ABO and Rh D typing was done by tube technique using monoclonal IgM (Tulip Diagnostic P Ltd.) Anti-A, Anti-B, Anti-D and pooled A, B and O cell.Results: A total of 25,559 blood group testing were done where we found 57 blood group discrepancies with overall frequency was 0.22%. Out of 57 discrepancies we were found 20 (35.09%) cases of technical error and 37 (64.91%) cases of sample related error. Among these sample related problems, we found weak/missing antibody, weak antigen expression, rouleaux, cold autoantibodies, cold alloantibodies, Bombay phenotype with the frequency of 13.51%, 2.70%, 2.70%, 54.06%, 8.11%, 18.92% respectively.Conclusions: Mistyping either a donor or a recipient can lead to transfusion with ABO-incompatible blood, which can result in severe hemolysis and may even result in the death of the recipient. Any discrepancy between forward and reverse blood grouping methods should be resolved before transfusion of blood components.
Bone marrow aspiration in haematological disorders: study at a tertiary care centre
Authors: Khan Subuh Parvez , Geelani Sajad , Akhter Shareefa , Bhat Shuaeb , Hussain Saleem , Manzoor Fahim , Rasool Javid , Khan Fiza Parvez
Published: June 2018

Background: The bone marrow examination is an essential investigation for the diagnosis and management of many disorders of the blood and bone marrow. Bone marrow aspiration (BMA) alone is usually sufficient to diagnose nutritional anaemias, and most of the acute leukaemias. Aim was to study the spectrum of haematological disorders diagnosed on bone marrow aspiration.Methods: This study was conducted in the Department of Clinical Haematology in Sher e Kashmir Institute of Medical Sciences, Kashmir for a period of 2 years from December 2015 to December 2017. Bone marrow examination of 2131 cases of suspected hematological disorders was carried out. Bone marrow was aspirated from posterior superior iliac spine under local anaesthesia. Aspirates of dry tap were excluded from the study. Aspiration smears where stained with Leishmann stain for morphological examination.Results: A total of 2131 cases were included in this study. Male to female ratio in our study was 1.9:1. The age range of cases was from 1-80 years and the mean age was 47.3 years. Anemia was the most common haematological disorder in our study accounting for 25.6% of cases followed by acute leukaemia accounting for 22.3% and multiple myeloma (13.3%). Among anemias, megaloblastic anemia was most common followed by dual deficieny anemia. Among leukaemias, acute myeloid leukaemia (13.2%) was more common than acute lymphoblastic leukaemia (9.1%).Conclusions: Bone marrow aspiration cytology is a mildly invasive technique which can diagnose many hematological and non-hematologic diseases that can be confirmed by more advanced investigations viz. serological, biochemical or molecular. It is a highly informative test procedure performed for evaluating blood and blood related diseases in our environment.
Assessment of micronutrient status during pregnancy attending at Kanpur, Uttar Pradesh, India
Authors: Tripathi Prashant , Rao Yashwant , Midha Tanu , Mishra Malvika
Published: June 2018

Background: This impression of multiple micronutrients during pregnancy emphasizes to relatively neglected issues. Objectives was to evaluate the status and benefits of multiple micronutrient during pregnancy.Methods: Total 180 healthy pregnant women were included, first trimester 60 cases, second trimester 60 cases and third trimester 60 cases in the age group of 18-40 years. Haemoglobin was estimated by cyanmethemoglobin method, estimation of iron was done by ferrozine method, for zinc colorimetric method, estimation of calcium OCPC method and estimation of urinary iodine was done by ammonium persulfate oxidation method.Results: Haemoglobin are found to be in the Ist trimester 11.3g/dl, in the IInd trimester of haemoglobin 10.5g/dl, and in the IIIrd trimester it was 11g/dl and Serum iron was 71.9ug/dl in Ist trimester, 74.8 ug/dl during IInd trimester, 80.9ug/dl in IIIrd trimester. The mean serum calcium during Ist trimester was found to be 8.0 ug/dl, in the IInd trimester 7.2 ug/dl and in the IIIrd trimester 8.1ug/dl. Serum zinc in the Ist trimester 72.6 ug/dl, in the IInd trimester 70.1ug/dl, in the IIIrd trimester 66.7 ug/dl respectively. Iodine level during Ist, IInd, IIIrd trimester was found to be 122.5ug/dl, 149.1ug/d, 158.7ug/dl respectively.Conclusions: Finding of our study shows that Poor nutrition during pregnancy has been associated with adverse maternal and child outcomes such as increased risks of infertility, abortion, fetal intrauterine growth restriction and prenatal mortality.
A comparative study of the clinical efficacy and safety of timolol 0.5% and travoprost 0.004% eye drops in primary open angle glaucoma
Authors: Bakkewar Shweta M. , Tamboli Saleem B. , Sahasthrabudhe Vivek M.
Published: June 2018

Background: Raised intraocular pressure (IOP) is a strong risk factor for development of glaucoma. If the condition is detected early enough it is possible to arrest the development or slow the progress with medication that lowers IOP. Travoprost is a newer prostaglandin analogue lowers IOP by facilitating outflow of aqueous humor.Methods: This was a prospective, randomized, open labelled, parallel group study, in which sixty cases of newly diagnosed primary open angle glaucoma (POAG) were included. After baseline clinical evaluation 30 subjects of glaucoma were treated with timolol 0.5% eye drop while another 30 subjects were given travoprost 0.004% eye drop and followed for 1 month to see IOP lowering efficacy of the two drugs. Statistical analysis was done using Open Epi 2.3 version for paired t test and unpaired t test.Results: In subjects treated with timolol eye drop mean reduction of IOP from baseline to week 4 was by 6.6mmHg while that of travoprost treated subjects was by 8.07mmHg. There was significant reduction in mean IOP of study subjects in travoprost group as compared to timolol group (P<0.05).Conclusions: Both timolol 0.5% and travoprost 0.004% eye drops are effective in reducing intra ocular pressure in POAG. On comparison travoprost was found to be statistically superior to timolol in lowering IOP in patients with POAG.
Prevalence of vitamin D deficiency in chronic obstructive pulmonary disease and it’s correlation with forced expiratory volume in one second: a tertiary care centre study
Authors: S. Laxma Reddy , Avala Ravicharan , Varma Rajshekar , Narahari Narendrakumar , K. Bhaskar , G. K. Paramjyothi
Published: June 2018

Background: Vitamin D deficiency is common all over the Indian subcontinent, with a prevalence of 70-100% in the general population. Vitamin D deficiency has a role in several diseases of the respiratory system including chronic obstructive pulmonary disease (COPD). Studies have shown that vitamin D deficient COPD patients have lower lung function measured by FEV1. We conducted a study to see prevalence of Vitamin D deficiency in COPD patients and it’s correlation with Forced Expiratory Volume in 1 second.Methods: A cross sectional observational study was performed in a tertiary care hospital in Hyderabad, Telangana during the period of one and half year. This included 104 COPD cases attending outpatient department of pulmonary medicine. Serum vitamin D levels were measured, and spirometry was done in all patients and data was analyzed accordingly.Results: Among 104 patients, 87 were males and 17 were females. Most of the study population (44.2%) was aged between 60-70 years. Mean BMI was 26.40 (±5.77) kg/m2. Majority of study populations (66.34%) were in GOLD stage 1 and 2. The mean Vitamin D value of the study population was 20.77±11.74ng/ml. Majority of the COPD patients were vitamin D deficient (69.2%). 25.0 % was severely deficient of vitamin D. The mean FEV1 volume (%) was 83.15±11.53, 60.97±17.47, 30.71±7.96 in sufficient, deficient and severe deficient patients.Conclusions: Vitamin D deficiency is common in COPD patients. Serum vitamin D deficiency increases with increased severity of COPD. There is positive correlation between serum vitamin D levels and post bronchodilator FEV1 (%).
Study of biochemical parameters of atherosclerosis male patients in tertiary care hospital of Rewa, Madhya Pradesh, India
Authors: Baghel Drutpal Singh , Patidar Adesh
Published: June 2018

Background: Atherosclerosis is characterized by intimal lesions called atheromas or atheromatous or fibro fatty plaques which protrude into and obstruct vascular lumens and weaken the underlying media. Global in distribution, atherosclerosis over whelming contributes to more mortality approximately half of all deaths and serious morbidity in the Western World than any other disorder. The atherosclerotic plaque is a lumpy thickening of the arterial wall, narrows the passage way and initiates the formation of a blood clot that can ultimately close down a critical artery. The objective of the study was to comparative biochemical parameters in different age group of atherosclerosis male patients.Methods: It was a prospective study, conducted in department of medicine of tertiary care hospital at Rewa. 30 atherosclerotic patients were selected for this study on the basis of inclusion and exclusion criteria, Biochemical testing was done for all patients and data of biochemical parameters were reported as the Mean±SD. Results were performed by the unpaired student’s t-test.Results: Total 30 atherosclerosis male patients and 27 normal healthy male volunteers were enrolled for the study. Biochemical parameters of both of this group were compared with t-test and p-value was found significant.Conclusions: Risk factors such as elevations in body mass index, systolic blood pressure, serum LDL cholesterol, triglyceride concentration and cigarette smoking are significantly related to the extent of atherosclerotic lesions.
Tumor necrosis factor (TNF) receptor associated periodic syndrome (TRAPS): a rare cause of recurrent fever
Authors: Gitte Sachin , G. Pradhan , M. Santoshi
Published: June 2018

The one year old male child presented with fever on and off, associated with periorbital swelling and arthritis. Infectious, rheumatological and oncological diagnoses were ruled out. Further follow-up over 4-5 years revealed that, the child continued to have similar episodes every month and investigated for almost all possible causes but no conclusive diagnosis was made. Hence evaluation for rare causes of periodic fever was considered. Genetic testing revealed mutation in a novel variant of TNFRSF1A gene, thus confirming Tumor necrosis factor receptor­associated periodic syndrome (TRAPS). Tumor necrosis factor receptor­associated periodic syndrome (TRAPS) is an autosomal dominant inherited condition of periodic fever and joint pain. Here we are presenting a case of this rare syndrome.
A systemic analysis of patients undergoing open ventral hernia repair (2011-2017)
Authors: Choudhry Esha A. , Sheth Jenish Y. , Darshan Jitendra R.
Published: June 2018

Background: The use of prosthetic mesh for reinforcing a hernia repair is considered most valid. Controversy exists regarding the use of the type of meshplasty. An insufficient evidence exists as to which type of mesh and mesh position (onlay, inlay, sublay (retrorectus) or preperitoneal) should be used. The effectiveness these methods have been systematically analysed in order to accelerate functional recovery and shorten hospitalization in patients undergoing open ventral hernia repair (VHR).Methods: This was a Prospective randomized single blinded comparative study conducted in the Department of Surgery at SMIMER hospital, Surat for patients presenting with the complaint of anterior abdominal wall hernia over a duration of 6 years (September 2011 - September 2017) with an average follow up period of 12 months, including 318 adult patients. All patients were preoperatively assessed clinically and by ultrasonography to confirm the diagnosis and randomized for open VHR after obtaining a well-informed written consent and satisfying the inclusion and exclusion criteria. 67% Patients (213/318) underwent retrorectus Meshplasty and were categorized into group A. The rest underwent Onlay (16.3% - 52/318)/Inlay (4.7% - 15/318)/Preperitoneal Meshplasty (11.9%-38/318) and were collectively (33% (105/318)) categorized into group B. Both Groups were Compared in terms differences in intra operative timing, intra operative complications, immediate post-operative outcome, early and delayed post- operative complications including readmission and recurrence rates.Results: Authors observed significantly lesser post-operative pain, higher well being, reduced wound complications and recurrence rate in group A. Mean duration of surgery was insignificantly higher for retrorectus meshplasty.Conclusions: Despite each method having its own advantages and disadvantages, retrorectus mesh repair was found superior because the mesh is placed with significant overlap under the muscular abdominal wall.
Laparoscopic resection of giant endometriotic cysts with mesenteric implantation
Authors: Espitia Francisco Terrazas , Dávila David Molina , Álvarez Jorge Fernández , Gallardo Luis Miguel , Lugo Pedro Brito , Ponton Pablo Avila
Published: June 2018

ndometriosis is defined as the presence of tissue which is histologically similar to the endometrium in locations outside the uterus. It affects women of reproductive age mainly and represents one of the main causes for hysterectomy and infertility amongst women. It has a broad spectrum of symptoms which make for a challenging diagnosis. Extragenital endometriosis affects up to 37% of all patients, and intestinal endometriosis has been observed in up to 12% of women affected by the disease, mainly involving the recto-sigmoid colon, ileocecal region and cecal appendix. Intestinal symptoms such as changes in depositional rhythm, diarrhoea and constipation are frequent and can evolve to acute abdominal obstruction in advanced stages of the disease. Authors present the case of a 51-year-old female that presented to the emergency room with abdominal, colic type, diffuse pain in the left flank, early satiety and postprandial fullness, CT scan revealed the presence of a lobed and septate mesenteric cystic tumor, of approximately 15.5 cm in diameter. Serum oncological markers were found to be within normal parameters. The patient underwent laparoscopic resection of the tumor with trans-operatory study, which ruled malignancy out and confirmed the presence of endometriotic tissue. The patient was discharged 72 hrs after surgery and prescribed anastrozole 1 mg orally every 24 hours. Follow up with Abdominal CT scan was performed 6 and 18 months later, showing no evidence of recurrence; the patient remains asymptomatic 18 months after surgery.
A rare case of a solitary perianal neurofibroma
Authors: Kim Dmitriy , George Elizabeth , Nalla Maheshwari , Chirayath Subin
Published: June 2018

Neurofibromas are benign nerve sheath tumors commonly associated with Neurofibromatosis type 1 (NF1). In patients without the diagnosis of the NF1, these lesions are referred to as solitary neurofibromas. Gastrointestinal involvement is exceedingly rare in NF1 and can manifest in a variety of different ways. This case report involves a 50-year-old hispanic female with an isolated neurofibroma of the perianal region in the absences of any medical or family history of NF1. Since there are very few cases of solitary neurofibromas reported in literature, it is important to document such cases and follow patients with this disease closely given that it can be an initial presentation of NF1 and because of its possible malignant potential.
Kissing sebaceous carcinoma of the eyelids: a rare case report
Authors: Rao Venkata Mahipathy Surya Rao , Chandrasekhar Senthil Kumar Azhisoor , Durairaj Alagar Raja , Rajamanohar Vimal Chander , Sundaramurthy Narayanamurthy , Ramachandran Manimaran
Published: June 2018

Sebaceous gland carcinomas are tumours of the skin adnexa which occur around the periocular region of elderly females. It is a rare malignancy usually involving the upper eyelid and has an indolent course. Treatment is surgical excision of the lesion with lid reconstruction. Here authors discuss a case of swellings involving both the eyelids of an elderly female diagnosed as sebaceous gland carcinoma on biopsy for which wide local excision and primary eyelid repair was done. This case has been presented as the lesion masquerades as a benign one but is malignant with multifocal spread.
Challenges for endocrine surgeons: management of a colossal normotensive pheochromocytoma
Authors: Hussain Zahir , Ferdinant Jabamalai , S. Senthilkumar M. , M. P. Kumaran , V. Saivishnupriya
Published: June 2018

Although the presentation of pheochromocytoma is remarkably protean, it usually presents as sustained or paroxysmal hypertension with triad of headache, palpitation and diaphoresis. The Incidence of serendipitously discovered pheochromocytoma is approximately 4% to 8%. Perioperative management of such cases are not only controversial but also poses infallible challenges to the surgeon. This case report intends to highlight an unusual presentation of asymptomatic, normotensive pheochromocytoma as a huge abdominal mass and its management.
Поддержка организаций инвалидов посредством предоставления им преференций при осуществлении государственных закупок
Authors: Скворцова Виктория Сергеевна
Published: June 2018

Предоставление преференций при осуществлении государственных закупок позволяет оказывать поддержку отдельным категориям участников. Российским законодательством о контрактной системе, в частности, предусмотрена поддержка организаций инвалидов посредством предоставления им ценовой преференции в случае их победы в процедуре закупки. Данная мера призвана способствовать интеграции инвалидов в общественное производство, что является одной из важных социальных задач современного государства. В данной работе проведен анализ реализации такой преференции на практике, выявлены проблемы и предложены возможные пути их устранения. Результаты исследования могут представлять интерес для государственных заказчиков, организаций инвалидов и контролирующих органов в сфере закупок.
Анализ требований работодателей к цифровым компетенциям сотрудников
Authors: Лезина Татьяна Андреевна , Юркова Анастасия Дмитриевна
Published: June 2018

В условиях цифровой экономики усиливаются требования к цифровым компетенциям сотрудников компаний. Мировые практики декларируют слияние функционала ИТ- менеджмента и топ менеджмента компаний. Российские профессиональные стандарты в той или иной степени подробности учитывают необходимость наличия цифровых компетенций у сотрудников разных уровней управления. Открытым остается вопрос о том, каковы реалии современного рынка труда. В статье анализируется status quo требований российских компаний к цифровым компетенциям управленцев высшего звена
Проблемы развития сферы бытовых услуг на уровне отраслевого рынка Республики Дагестан
Authors: Казибекова Наида Аликулиевна , Моллаева Наврияханум Герейхановна
Published: June 2018

Проблемы эффективного функционирования и развития сферы бытовых услуг являются актуальными в экономике, так как предприятия бытовых услуг в современных условиях хозяйствования, претерпевают влияние кризисных явлений. В статье рассматриваются состояние и тенденции развития сферы бытовых услуг на уровне отраслевого рынка Республики Дагестан. В статье выделены этапы формирования и развития сферы бытовых услуг в регионе, определены темпы роста платежеспособного спроса и объемов предоставленных платных услуг на отраслевом рынке в Республике Дагестан, оценены колебания значений видов услуг и определена закономерность тренда. Методические разработки и расчеты могут быть использованы при совершенствовании механизмов управления сферой бытовых услуг.
Индексы миграционных и усложненных дрифтов в макропруденциальном регулировании
Authors: Гроссман Юрий Александрович
Published: June 2018

Данная статья посвящена вопросу совершения российской системы макропруденциального регулирования с помощью индексов миграционного и усложненного дрифта, строящихся на основе матриц рейтинговых миграций. Автором была выявлена необходимость внедрения нового инструмента прогнозирования кризисных явлений, вытекающая из недостаточной предсказательной способности моделей применяемых в настоящий момент в этих целях. В статье приводится анализ международной и отечественной практики макропруденциального регулирования, включая ключевые принципы и аспекты его реализации, а также сравнительный анализ современных инструментов выявления уязвимостей финансовой системы, в т.ч. используемых Банком России. На основании проведенного анализа устанавливается, что индексы миграционного и усложненного дрифтов по ряду параметров превосходят другие аналогичные индикаторы, не обладая их недостатками, и благодаря этому способны существенно усилить инструментарий российского макропруденциального регулирования в части прогнозирования негативных рыночных тенденций, экспресс оценки состояния экономики и отдельных рынков.
Интегрально-маркетинговые методы развития регионального туризма как фактор повышения социо-эколого-экономической устойчивости региона
Authors: Щетинина Екатерина Даниловна , Дагман Сара
Published: June 2018

В статье изложены подходы к формированию интегрально-маркетинговых методов развития туризма региона как фактора повышения региональной социо-эколого-экономической устойчивости. Рассмотрен связанный с этим круг методических и практических проблем, тенденции туристического маркетинга и его современные особенности на примере Белгородской области. Исследован методический аппарат маркетинга в туризме, выявлена взаимосвязь туризма и развития территории и обоснована необходимость формирования интегрального маркетингового пространства для повышения устойчивости и сбалансированности социо-эколого-экономического развития региона. В качестве методологической базы для этой цели предложен синтез трех видов маркетинга – туристического, регионального и отношенческого в их социально-этической форме. Определены компоненты и параметры устойчивости туристического маркетинга, учитывающие интересы региона. В качестве одного из инструментов интегрированного маркетинга предложена расширенная типология потребителей рынка туристических услуг. Установлены принципы оценки эффективности туристического маркетинга на основе учета мультипликативного эффекта и влияния на валовый региональный продукт (ВРП). Намечены программные блоки практической реализации стратегии устойчивого развития региона, связанные с туристическим сектором как драйвером этого развития.
Effects of Canagliflozin on Fatty Liver Indexes in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials
Authors: Li Boyu , Wang Ying , Ye Zhikang , Yang Hui , Cui Xiangli , Wang Zhenjun , Liu Lihong
Published: June 2018

PURPOSE: Non-alcoholic fatty liver disease (NAFLD) affects about 75% of patients with type 2 diabetes mellitus (T2DM). We conducted a meta-analysis to determine the effect of canagliflozin on fatty liver indexes in T2DM patients. METHODS: A literature search of PubMed, Embase and Cochrane was conducted up to March 30, 2017. The liver function test and lipid profile were extracted from randomized controlled trials (RCTs) to evaluate the effect of canagliflozin on fatty liver. Weighted mean differences (WMDs) or relative risks and 95% confidence intervals (CIs) were computed by using either fixed or random-effects models. Sensitivity analysis and publication bias were evaluated. RESULTS: Our results showed that canagliflozin decreased serum concentrations of  alanine amino transferase (WMD: -11.68 [95% CI: -18.95, -10.95]; P<0.001), aspartate amino transferase (WMD: -7.50 [95% CI: -10.61, -4.38]; P<0.001), gamma-glutamyl transferase (WMD: -15.17 [95% CI: -17.73, -12.61]; P<0.001), triglycerides (WMD: -0.10 [95% CI: -0.15, -0.05]; P<0.001) but increased low-density lipoprotein cholesterol (WMD: 0.1 [95% CI: 0.06, 0.13]; P<0.001), high-density lipoprotein cholesterol (WMD: 0.06 [95% CI: 0.05, 0.07]; P<0.001) at week 26 or 52. CONCLUSIONS: Our results indicated that canagliflozin may have a protective effect on fatty liver in T2DM patients. The limitation was that the liver biopsy was hard to obtain in published studies. More RCTs specified on NAFLD are needed to get further information. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.