bluuebunny/crossref_metadata_2025 huggingface dataset:
VERİ MADENCİLİĞİ VE SPOR ALANINDAKİ UYGULAMALARI
Authors: Murathan Talha , Devecioğlu Sebahattin
Published: November 2018

Hızla
gelişen teknolojiyle birlikte depolanan verilerde de çok fazla artış olmuştur.
Bu kadar çok veri arasından önemli ve istenilen verilerin ayırt edilebilmesi
çok önemlidir. Bunun için en etkin kullanılan yöntem veri madenciliği
yöntemidir. Veri madenciliği en kısa tanımıyla depolama ortamına kaydedilmiş
çok fazla veri arasından istenilen, önemli ve değerli bilgilerin ortaya
çıkarılmasıdır. Yeni bir konu olmakla birlikte çok fazla uygulama alanı
bulunmaktadır. En fazla uygulama yapılan alanlar tıp, biyoloji ve genetiktir.
Bu çalışmanın amacı veri madenciliğinin spor alanında kullanımının
incelenmesidir. Ülkemizde sporda veri madenciliğiyle ilgili çok fazla bilimsel
çalışma bulunmazken, yurtdışında bu alan oldukça gelişmiştir. Spor veri
madenciliği teknikleri için oldukça uygun bir alandır. Sporcular, takımlar,
müsabakalar ve sezonlarla ilgili çok fazla veri bulunmaktadır. Bu verilerin
analiz edilmesiyle gelecekteki müsabakaların skorları tahmin edilebilmekte,
oyunda yeni stratejiler belirlenebilmekte, sporcu, antrenör, tesis, sporcu araç
gereçleri seçimlerinde bu verilerden yararlanılabilmekte, performans
değerlendirmesi, sporcu sakatlanma riskleri, bilet satış tahminleri ve analizleri
yapılabilmektedir.
Association between placental insufficiency and manifestations of preeclampsia
Authors: Strizhakov A. N. , Tezikov Yu. V. , Lipatov I. S. , Pechkurov D. V.
Published: November 2018

Aim. Provide evidence for the connection between placental insufficiency and preeclampsia and rationalize a unified approach to the prevention of placenta associated disorders. Materials and methods. The study was carried out in two stages. At the first (clinical statistical) stage, the incidence rates of preeclampsia (PE) and placental insufficiency (PI) were compared based on the data from Rosstat and from a regional perinatal center for the past 25 years; the most informative predictors of PI and PE were compared using the known clinical epidemiological tests. At the second stage, a prospective study of 140 high-risk pregnant patients with severe PI was carried out to confirm and generalize the hypothesis on the common predictors of PI and PE. Two groups of patients were compared: I – 68 women with isolated PI and II – 72 women with PI combined with earlyor late-onset PE. The control group included 30 women with uncomplicated pregnancy. Immunoenzyme assays, immunofluorescence, biochemical analyses, and morphological studies of placenta were used. Results. The incidence rates of PI and PE, both in the communities and in the tertiary care hospital, pointed to their intercorrelation. This similarity of informative values of PI and PE predictors related to the most important operational characteristics of clinical epidemiology indicates the lack of pathognomonic significance of the early predictors and, on the other hand, supports the concept of the common mechanisms of placenta-associated pregnancy complications. In pregnant women with a high risk of PI decompensation, PE developed in 51% of cases (early-onset – 72%, late-onset – 28%); of those, 18% were diagnosed with severe PE, and 33% – with moderate PE. The obtained data confirm that the manifestation of early-onset PE is pathogenetically related to structural and functional disorders of the early fetoplacental complex (FPC), while late-onset PE is associated with FPC changes in the subsequent stages of pregnancy, and with a synergistic effect of extragenital and obstetrical pathology. The proposed predictive model of PE connects the manifestation of PE with the status of the placenta. Conclusion. The knowledge of pathogenetically significant risk factors allows for stratifying pregnant women in order to conduct a common preventive monotherapy of placenta associated disorders. The present approach to the management of high-risk pregnancy is in line with the principles of 4Р-medicine.
Oxidative stress, endothelial dysfunction, cytokine imbalance, gonadotropic synergism, or all about tocopherol in the practice of an obstetrician-gynecologist
Authors: Dzhobava E. M.
Published: November 2018

Generation of reactive oxygen species (ROS) occurs in every human. The condition of oxidative stress develops when the human antioxidant defenses including the enzymes superoxide dismutase, peroxidases etc., and biological antioxidant molecules, are insufficient. Vitamin E is part of the antioxidant family. It plays a key role in neutralizing ROS, and its scope of activity ranges from the inhibition of heme biosynthesis and lipid peroxidation to maintaining the collagen/elastin balance. Vitamin E deficiency may be either primary or secondary; both shift the balance towards the development of oxidative stress, which may affect the normal course of pregnancy. As a result, pregnancy loss or preterm birth may ensue. Moreover, the oxidative stress can have a negative impact on the development of a fetus. In addition, the oxidative stress may play a role in various female reproductive disorders, eventually leading to infertility. In the today’s world, the popular commitment to low-cholesterol and low-fat diets often leads to an increasing number of women with vitamin E deficiency. In order to maintain normal pregnancy, this imbalance requires an adequate correction starting at the stage of preconception care.
Neuroimaging of full term newborn´s brain with hypoxic-ischemic encephalopathy
Authors: Melashenko Tatiana V , Pozdnyakov Alexander V , Alexandrov Timofey A
Published: November 2018

Introduction. Hypoxic-ischemic encephalopathy (HIE) in full term newborn is the most frequent courses of neonatal mortality and development of neurology handicap. Magnetic resonance imaging (MRI) is common noninvasive method for detect of post hypoxic brain lesions in newborn. Method of research. We assessed MR-pattern of hypoxic brain injury using Philips Ingenia 1.5 Tl for examination newborn on 14-16 days after delivery. Protocol of MRI scans included axial and coronal plan T1, T2, Flair weighted imaging (WI) and diffusion tensor imaging (DTI) with program Fiber tracking and detected fractional anisotropy (FA). FA was measuring within cortico-spinal tract besides. 3D reconstruction allowed to visualized white matter along the axon direction of cortico-spinal tract. Studies. Four full term newborn (after 37 weeks gestation) have been examined and separated in two groups. First group included newborns with HIE (evidence of fetal distress, low Apgar Scores, low umbilical cord pH ˂ 7.1, necessity for resuscitation and neurological signs, second group consisted term newborn without any medical and problems of health. Results of research. We detected MR-patterns of basal ganglia and thalamus lesions in newborn with HIE (abnormal high signal intensity on T1 and Flair WI). We didn’t detect any abnormal MR scans in healthy newborns (control group). FA within cortico-spinal tracts besides (total and ROI-1) were lower in newborns with HI then in healthy ones. Conclusion. This investigation showed common MR patterns of brain lesions in full term newborns with HIE which included changes of signal intensity T1 and Flair from basal ganglia and thalamus as well as reduction of FA within cortico-spinal tract.
Vegetative Status with Arterial Hypertension in the Indigenous Population of the Far North and Migrants
Authors: Lytaev Sergey A , Tolstova Ekaterina A
Published: November 2018

The increase of sympathetic activity can serve as a starting point for increase blood pressure for both humans and experimental animals. Activation of the sympathetic nervous system is important not only in the early stages of the disease but also contributes to the formation of the cardiovascular risk in life later. Comparative information about the vegetative status of indigenous people and migrants with hypertension in the Far North in a systematic scientific literature not presented. The purpose of this research was aimed for study of the dynamics of the vegetative status in patients with arterial hypertension in the Far North indigenous people and migrants. Condition of the autonomic nervous system by the residents of the Russian Far North with arterial hypertension was evaluated. The data using cardiointervalography and active orthostatic test in the indigenous population and migrants from Nadym district of the Tyumen region in the age of 18-60 years were obtained. The study involved 220 people working-age population (86 migrants and 134 indigenous peoples of the Far North). Among them are 41 patients with hypertension (26 migrants and 15 indigenous people). The average age of the surveyed migrants amounted to 40,1 ± 13,4 years for indigenous 37,8 ± 12,4 years. The duration of stay in the Far North for migrants was 14,9 ± 10,7 years. 5 options for autonomic tone, as well as differences in the autonomic nervous system disorders among migrants and indigenous peoples of the Far North with hypertension patients were installed. Violations of the autonomic nervous system for migrant are mild sympathicotonia coupled with significant impairment of vegetative support activities. It is typical for an unfavorable course of adaptation processes. For indigenous people the change reduces to a shift towards sympathicotonia without significant changes in vegetative support activities.
Whole exome sequencing: principles and diagnostic capabilities
Authors: Suspitsin Evgeny N , Tyurin Vladislav I , Imyanitov Evgeny N , Sokolenko Anna P
Published: November 2018

Diagnostics of genetic diseases in clinical routine often presents a challenge. In particular, most of hereditary diseases are exceptionally rare and therefore unfamiliar to practicing physicians. Furthermore, even if the diagnosis of a particular genetic condition appears convincing on the level of clinical evidence, the causative mutation often remains unknown due to limitations in DNA testing procedures. Recently developed high-throughput sequencing technologies (Next Generation Sequencing, NGS; synonym: massive parallel sequencing) provide a breakthrough in medical genetics. While in the past genetic testing was limited to a single gene or, at best, to a small number of genes, NGS is compatible with a large-scale DNA analysis. One of the most popular applications of NGS is whole exome sequencing (WES), which allows simultaneous reading of coding sequences (exons) of all known genes. Although this technology exists only for a few years, its use has already led to discovery of the causes of more than 150 genetic syndromes. Furthermore, WES may be recommended for the use in clinical routine for selected patients with orphan disease, especially for the families with multiple affected relative. It is likely that WES will become a powerful screening tool in the near future. This review discusses general principles of WES as well as the applications of this technology in medicine.
Features gastroduodenal pathology in military age patients with malnutrition
Authors: Vyutrikh Elena V , Antipova Maria V , Bodareva Natalya V , Gergel Anna O
Published: November 2018

Background.Digestive diseases are a leading cause of body weight deficit and has a leading position among general morbidity in young patients.Purpose.To analyze the pathology of the upper digestive tract in young men with a low body weight.Material and methods.193 young men aged 16-27 y.o. (mean age 20,3±2,2 years) with a mean body mass index (BMI) 17,8±2,4 kg/m2were examined. Erosive lesions of the stomach were found in 18,8% (n=36) and erosive lesions of the duodenum – in 16,1% (n=31). Ucer of duodenum were found in 11,4% (n=22) and none of stomach. Duodenal reflux were found in (51,8%;n=100) and every fourth was combined with erosive gastritis. Histological examination of stomach revealed an inflammation in all cases. Atrophic changes in the antral stomach were detected in 11% (n=6) of the cases. All cases of atrophy accompanied by HP colonization. In the group with normal BMI the prevalence of cardia failure, erosive lesions of the esophagus, stomach and duodenum were founded. In the same group there were prevalence of stomach inflammation by histology (44%). The patients with low BMI (hypotrophy 1 degree) have less erosion and inflammation compare to patients with normal BMI and hypotrophy 2-3 degrees.Conclusions.1. Stomach inflammation were revealed in the majority of young men with low BMI. Atrophic changes of gastric antrum associated with HP infection were found in 10% of cases. 2. Erosive lesions of the esophagus, stomach and duodenal are associated with the BMI. This finding allows use the BMI as an integral indicator of the severity of the inflammation of stomach and duodenum. Erosive lesions of the upper digestive tract are found predominantly in patients with normal BMI.
Structural and functional state of arteries in women with metabolic syndrome associated with autoimmune thyroiditis
Authors: Kanavets Natalia S , Levina Lilia I , Vasilenko Vladimir S , Karpovskaya Ekaterina B , Ribka Tatiana G , Ivanov Sergei N
Published: November 2018

The aim of the research was to study structural and functional state of arteries in women with metabolic syndrome (MS) associated to autoimmune thyroiditis (AIT), to improve the efficiency of therapeutic and preventive measures. The study sample included 108 women, 40 of them were with metabolic syndrome, autoimmune thyroiditis and euthyroidism (group I), the second group consisted of 31 women with metabolic syndrome, autoimmune thyroiditis and subclinical hypothyroidism (group II) and control group included 37 women with metabolic syndrome without thyroid disease. Laboratory examination included the study of lipid profile ( cholesterol, low-density lipoproteins, LDL Very Low Density Lipoprotein, VLDL, high-density lipoproteins, HDL, triglycerides, atherogenic index), thyroid hormone levels (ATPO and ATG, fТ4, T3) and thyroid stimulating hormone (TSH). Also, patients were instrumental examination with ultrasound of the brachial artery to assess endothelium dependent and endothelium independent relaxation, the definition of complex intima-media thickness. In addition, it performed ultrasound of the kidneys with renal artery duplex scanning with the assessment of renovascular hemodynamics. All patients of the research showed elevated arterial stiffness endothelial dysfunction and remodeling of the vascular wall. These changes are most pronounced in women with metabolic syndrome associated with autoimmune thyroiditis and subclinical hypothyroidism.
Catalytic Activity of FeCrNiWMoCoCB Metallic Glass Coatings on a Metal Support in Dye Wastewater Treatment
Authors: Burkov A. A. , Zaitsev A. V.
Published: November 2018

Catalytic activity of FeCrNiWMoCoCB metallic glass (MG) coatings deposited on steel 1035 was studied in decomposition of the model solution of methylene blue. Five samples with different compositions and predominantly amorphous structure were synthesized by depositing MG coatings using the electrospark treatment in the crystalline alloy granule medium. The Ra criterion characterizing the coatings roughness was 9 to 14 mm that indicated the considerable area of interaction between MG and methylene blue. The presence of nickel and cobalt but not tungsten and molybdenum in the metallic glass favored an increase in the catalytic activity of the coatings. The best catalytic properties were inherent in the coatings consisted of Fe33Cr8Ni8W8Mo8Co8C16B11which provided a decrease in the activation energy of self-decomposition of methylene blue to one eighth in the presence of hydrogen peroxide. It was shown that the efficiency of this catalytic system could be increased by a factor of 3 upon etching in 30 % HNO3for 380 s due to an increase in the porosity and in the specific surface area of the coating. The suggested approach makes it possible to decrease considerably the prime cost of the catalytic units of the reactor owing to application of one-stage supporting of MG coating on the metals.
Catalysts for Synthesis of Liquid Hydrocarbons from Methanol and Dimethyl Ether: Review
Authors: Matieva Z. M. , Snatenkova Yu. M. , Kolesnichenko N. V. , Khadzhiev S. N.
Published: November 2018

Various methods for improving the catalyst selectivity to conversion of oxygenates to liquid hydrocarbons are discussed. Literature analysis reveals that the key factors determining the selectivity of zeolite-containing catalysts are the structure type and acid properties of the zeolite. The strength and distribution of the acid sites are shown to depend on the structure type and chemical composition of the zeolite framework, as well as on the chemical nature of exchange cations. Methods for changing acid properties of zeolites are considered, among which are modifying with various cations, post-synthetic acid, alkali or steam treatment.
Methods for Synthesis of Triethanolamine: Review
Authors: Yushchenko D. Yu. , Zhizhina E. G. , Pai Z. P.
Published: November 2018

Triethanolamine (TEA) is a high-demand chemical product used in numerous sectors of industry (textile and cement industries, production of lubricating fluids, cosmetics, household chemicals, pharmaceutics, etc.). The product quality and consumer properties depend on the preparation technology. In the review paper, various, including catalytic, methods for TEA preparation are discussed with regard to the product purity and the target applications. Additional methods for improving the consumer properties of the synthesized TEA also are considered.
The mMiR-223: An inflammatory MicroRNA Involved in Pathogenesis of Multiple Sclerosis
Authors: Gharibi Saba , Moghimi Bahram , Taher Tahoori Mohammad , Bagher Mahmudi Mohammad , Shahvazian Ensieh , Farashahi Yazd Ehsan
Published: November 2018

Multiple sclerosis (MS) is the most common autoimmune inflammatory demyelinating disease that affects the brain and spinal cord. Dysregulation or mutation of miRNA genes have been linked to the pathogenesis of MS. The miRNAs are short, 20-22 nucleotide long, single-stranded regulatory and non–protein coding RNAs that modulate the expression of multiple target genes. Among miRNAs, miR-223 has been reported to play a critical role in MS. This review concentrates on the emerging role of miR-223 in inflammatory responses and specifically discusses how alterations in miR-223 expression are associated with the development of MS. This review also suggests that miR-223 can be used as a biomarker for diagnosis of MS and discovering novel therapeutics for MS treatment.
The Beneficial Effects of Fiber on Major Chronic Diseases: A Review of Evidence
Authors: Zeinali Fahime , Samadi Mehnoosh , Hojjati Niloofar
Published: November 2018

Background: Fiber is a carbohydrate, which is neither completely digested nor absorbed in the small intestine, but may be fermented and plays a key role in the human health. We investigated the beneficial effects of fiber on major chronic diseases. Methods: It was extracted the relevant articles by searching the PubMed, ScienceDirect, and Scopus databases using the following keywords: dietary fiber, carbohydrate fermentation, short chain fatty acids, cardiovascular disease, diabetes, cancer, constipation, and appetite. In this research, a variety of studies were investigated including prospective cohort, case-control, cross-sectional, and clinical trial. The thematic relation of these studies was evaluated by reviewing their titles and abstracts. Results: From a total of 123 articles, 27 related studies with appropriate design and reliable information were selected and reviewed. Considering the selected studies, 13 were clinical trials, 10 articles were cohort, one was case-control, and three studies were cross-sectional. The studies investigated the beneficial effects of fiber on cardiovascular diseases (N = 4), type 2 diabetes (N = 8), appetite control and body weight (N = 3), colorectal cancer (N = 4), breast cancer (N = 2), immune system (N = 3), and constipation (N = 3). According to the results of this study, fiber reduces the rate of gastrointestinal discharges; this in turn leads to decrease of the glucose uptake and increases the satiety. More fiber consumption was associated with improvement of the immune system, weight control, reduction of the cardiovascular diseases, diabetes, colon cancer, and breast cancer. Conclusions: Regular consumption of fiber has beneficial health outcomes. However, these benefits depend largely on the types of the consumed fiber and the individual who intakes them.
Distributed Approach to Cloud Oriented E-Marketplaces: a Constructive Review
Authors: O. Ige Ayokunle , A.O. Akingbesote , O.L. Ogbeide
Published: November 2018

The need to have rapid access to various service by various customers brought about the introduction of cloud e-marketplaces. The goal of the cloud e-marketplace is to attract the biggest possible number of buyers and also ensure that the quality of the delivered services is sustained. Even though various literatures exist on cloud oriented marketplace, most of these literatures are short of some important details. This review paper provides a better literature on cloud oriented e-marketplaces by discussing the evolution, features, existing research, challenges and in addition, concluded that the future approach that will allow optimized performance in cloud e-marketplaces’ would be to consider the servers being used for cloud service delivery as a group of distributed systems.
Análisis de los hábitos de viaje del turismo social en México, específicamente, del segmento de bajos ingresos
Authors: Cerón Monroy Hazael , Lechuga Besné Mariano Alberto
Published: November 2018

El turismo social se define como el conjunto de relaciones y fenómenos que resultan de la participación de las capas sociales con bajos ingresos en la realización de consumo turístico. Para conocer este tipo de turismo, fue necesario primero identificar qué significa “bajos ingresos” para la sociedad mexicana. El objetivo general consiste en caracterizar los hábitos de viaje de las personas de bajos ingresos provenientes de las grandes ciudades de México y que tienen la probabilidad de realizar un viaje. La metodología empleada consideró primero identificar el segmento de bajos ingresos de forma cuantitativa y cualitativa. Con un análisis contrafactual basado en los datos de la Encuesta nacional de ingresos y gastos de los hogares (enigh) 2012 (inegi, 2013), se estima el umbral de ingreso que define a este grupo de personas. Posteriormente, se realizó un estudio cualitativo con grupos de enfoque que identificaran características inherentes al segmento de bajos ingresos. Por medio de un análisis anova de la intención de viaje y como resultado de los grupos focales, se determinaron cuatro perfiles. El segundo elemento de la metodología consistió en realizar una muestra no probabilística a 1.584 personas en Ciudad de México, Guadalajara y Monterrey para conocer sus hábitos de viaje. Se encuestó a personas considerando el rango de 18 a 65 años de edad, con un ingreso familiar mensual de entre 7.122 y 11.446 pesos mexicanos, sin tarjeta de crédito. Entre los hábitos de viajes se identificaron cuatro perfiles con elementos como los siguientes: transporte, actividades, financiamiento, hospedaje, principales destinos visitados, servicios turísticos utilizados, gasto promedio, motivaciones de viaje, estacionalidad, experiencias compartidas, obstáculos, planeación, creencias, satisfacción y sensibilidad de precios. Se concluye que los realizadores de turismo social hacen un esfuerzo por viajar, y gran parte de ellos realiza sus viajes por medio de la cooperación y con hábitos particulares tales como poseer poca información, viajar exclusivamente para descansar, viajar a lugares cercanos y gastar alrededor de 84 dólares diarios.
¿Puede el turismo ayudar a la valorización del dulce típico de leche en Toluca, Estado de México? Análisis por medio de la cadena de valor
Authors: Guadarrama García Luis , Palmas Castrejón Yanelli Daniela , Herrera Tapia Francisco , Thomé Ortiz Humberto
Published: November 2018

El dulce típico de leche de Toluca (México) cuenta con una historia de más 120 años; sin embargo, frente a las presiones de la globalización y la llegada de productos extranjeros, este ha experimentado desplazamiento y pérdida de competitividad en el mercado. Por tal motivo, surgió la necesidad de conocer si el turismo puede ayudar a la valorización de este producto. Para ello, se realizó un análisis basado en la metodología link 2.0 y la Guía metodológica para el análisis de cadenas productivas. Por medio de la cadena de valor, se seleccionaron cinco dulces, debido a que contaban con características de identidad; además, se analizó su contexto histórico, territorial, las fuerzas externas que influyen en los dulces, el saber-hacer y al artesano. Como conclusión, se puede afirmar que los productos y sus características son un atractivo para el turismo, pues este denota interés en el consumo de lo típico, por lo tanto, esta actividad puede ayudar a valorizarlo. Además, se tiene como hallazgo la necesidad de construcción de conceptos que integran a la gastronomía, en este caso, el significado del dulce típico de leche.
Análisis ecoturístico de la actividad de snorkelling en Majayura (Cartagena, Colombia)
Authors: Jacob –Lozano Florina , Echeverry-Galvis María Ángela
Published: November 2018

Los arrecifes de coral en las áreas marinas protegidas son un importante atractivo turístico cuyo sobreúso para fines turísticos puede generar cambios en su estructura. El propósito de esta investigación es describir la actividad de snorkelling en un sendero del Parque Nacional Natural Corales del Rosario y San Bernardo (Colombia) durante un período de alta afluencia turística y evidenciar oportunidades de manejo. Se evalúan cambios en la cobertura bentónica en dos transectos con y sin snorkelling y se realiza una descripción de las prácticas en uso de los guías por medio de observaciones participantes y entrevistas. No hubo cambios temporales en la cobertura de los componentes bénticos, pero sí hubo diferencias entre el sendero sin y con turismo. Se registró mayor número de contactos al sustrato por parte de los turistas al inicio de la actividad. A partir de la descripción de la actividad, se presentan recomendaciones para mejorar sus condiciones, tanto para el ecosistema como para los usuarios.
Mitigating Infant Medical Trauma in the NICU: Skin-to-Skin Contact as a Trauma-Informed, Age-Appropriate Best Practice
Authors: Eliades Carly
Published: November 2018

Infant medical trauma in the NICU is associated with serious and lasting consequences. Skin-to-skin contact (SSC) of infants with their parents is a nursing intervention that provides significant benefits and can mitigate the negative consequences of the infant’s traumatic experiences in the NICU. The purpose of this article is to explain how SSC aligns with the concept of trauma-informed age-appropriate care (TIAAC) in the NICU. The evidence supporting SSC will be reviewed and discussed using TIAAC as a framework. SSC is an effective and evidence-based care strategy that reduces the infant’s traumatic NICU experiences by improving parental proximity, attachment, and lactation; decreasing stress and pain; improving physiologic stability; supporting sleep; and enhancing neurologic outcomes.
Differential Diagnoses and Their Implications of Dandy-Walker Malformation or Isolated Cisterna Magna, a Case Study: Baby V
Authors: Weaver Nicole L. , Bradshaw Wanda T. , Blake Stephanie McCallum
Published: November 2018

We explore the outcome of a fetus with a posterior fossa abnormality thought to be a Dandy-Walker malformation based on prenatal ultrasound imaging. The infant was later diagnosed by magnetic resonance imaging (MRI) as having an isolated cisterna magna. When assessing brain abnormalities, there is increased accuracy of prenatal MRI versus prenatal ultrasound. Accurate diagnosis of an infant is paramount so that an inheritance pattern, risk of recurrence, involvement of other systems, and a prognosis can be determined. Communicating with the family and supporting them with the correct information is then enhanced. It should be standard protocol to obtain a fetal MRI if an abnormal prenatal ultrasound of the brain is detected. Further research is needed to assess the accuracy of using MRI versus ultrasonography prenatally to diagnose posterior brain abnormalities.
Perspectivas para un estudio sobre bilingüismo en universidades regionales colombianas
Authors: Cárdenas Vergaño Nélida
Published: November 2018

En el presente artículo se hace una reflexión sobre las tendencias del bilingüismo en Colombia, brindando una reseña histórica de la forma como se introdujo al país la enseñanza de los idiomas extranjeros, además de abordar algunos aspectos conceptuales y teóricos sobre la definición y tipos de bilingüismo que han marcado influencia para las propuestas del Ministerio de Educación Nacional en el área. Más adelante se describe el Proyecto de Fortalecimiento a Licenciaturas en Idiomas/Inglés, propuesto en el marco del Programa Nacional de Bilingüismo-PNB 2004-2019, todo ello con el fin de presentar los fundamentosmetodológicos de la propuesta investigativa “Políticas bilingües y su impacto en la identidad cultural y calidad educativa en programas de licenciatura en lenguas - inglés en Colombia, 2004-2014”, correspondiente al Doctorado en Ciencias de la Educación de Rudecolombia - cade,Tunja, grupo de investigación Historia y Prospectiva de la Educación en América Latina - hisula.
As formas de tratamento no Teatro do Rio de Janeiro dos séculos XIX e XX
Authors: Machado Ana Carolina Morito
Published: November 2018

Este trabalho tem como objetivo analisar o comportamento das formas de tratamento ao interlocutor, que, nesta pesquisa, são consideradas Tradições Discursivas, na variedade do Rio de Janeiro no Português Brasileiro dos séculos XIX e XX. A distribuição dessas estratégias foi investigada em quatorze peças de teatro, à luz da teoria do Poder e da Solidariedade (Brown e Gilman, 2003[1960]). Os resultados apontam para uma predominância de tu até a primeira década do século XX e a preponderância absoluta da forma você, a partir da segunda década do século XX , especialmente nas relações simétricas solidárias e nas relações assimétricas ascendentes. Ressalta-se também o significativo emprego da forma nominal o(a) senhor(a), devido principalmente à presença de altos índices dessa forma nas relações simétricas não-solidárias e nas relações assimétricas ascendentes.
No caçar dos erros, a língua que escapa
Authors: Noble Debbie Mello
Published: November 2018

Este artigo, ancorado na Análise do Discurso pêcheuxtiana, objetiva analisar o funcionamento dos dizeres sobre o revisor de textos da publicidade a partir de um corpus experimental, que consta de entrevistas com sujeitos envolvidos na etapa de revisão do processo de criação publicitária. Podemos dizer que o objeto analisado é bastante específico, e, até mesmo, contraditório, posto que a publicidade, em geral, trabalha com uma linguagem coloquial, enquanto a revisão de textos pode ser vista como uma tentativa de blindar a língua, torná-la perfeita e evitar os erros. No entanto, ao observar esta contradição, percebemos algumas outras possibilidades de pensar a língua e o espaço de dizeres da publicidade. A relação língua/revisão de textos permeia as sequências discursivas (SDs) analisadas. Nelas, observamos uma relação de repetibilidade na forma de pré-construídos: o revisor de textos é descrito como um sujeito que domina plenamente a língua portuguesa, um detentor dos conhecimentos gramaticais, uma vez que se toma a noção de língua pela de gramática. Assim, buscamos compreender de que forma esses pré-construídos se constituíram historicamente e que regiões do interdiscurso são mobilizadas para que intervenham como efeito de memória nos dizeres desses sujeitos.
Extent of Use of Information and Communications Technology and Inventory Management in the Nigerian Brewery Industry
Authors: Odesola Olusegun Timothy , Akinola Grace Oluyemisi
Published: November 2018

This paper examined the extent of usage of Information and Communications Technology (ICT) for inventory management in the Nigerian brewery industry; investigated the level of adoption of ICT in the inventory management phases; and the effect of the extent of ICT usage on its adoption by firms in the industry. Primary data formed the methodology of the study. The analysis of data collected was done using descriptive (tables and percentages) and inferential statistics. The results showed that majority of the respondents were using ICT tools and its associated components in their inventory management. It was revealed that the extent of ICT usage had significant effect on its adoption for inventory management by firms in the industry. Based on these findings, the study concluded that ICT is fully deployed and adopted to a very great extent for inventory management in the Nigerian brewery industry and that its adoption and usage in the brewery industry was influenced by its extent of use. The study recommends that firms in the industry should make judicious use of the identified ICT usage by adopting ICT solutions for their operations to boost the efficiency and effectiveness of their operations.
The Latent of Student Learning Analytic with K-mean Clustering for Student Behaviour Classification
Authors: Mansur Andi Besse Firdausiah , Yusof Norazah
Published: November 2018

Since the booming of “big data” or “data analytic” topics, it has drawn attention toward several research areas such as: student behavior classification, video surveillance, automatic navigation and etc. This paper present k-mean clustering technique to monitor and assess the student performance and behavior as well as give improvement toward e-learning system in the future. Data set of student performance along with teacher attributes are collected then analyzed, it was filtered into 6 attributes of teacher that may potentially affect the student performance. Afterwards, k-mean clustering applied into the filtered data set to generate particular cluster number. The result reveal that Teacher1 statistically hold the highest density (0.27) and teachers with good speech/lectures tend to have strong correlation with another factor such as: commitment of teacher on preparing lecture material and time management utilization. If this synergy between teacher and student running flawlessly, it will be great achievement for e-learning system to the society.
Open Source Web Platform for the Analysis of Academic Spin-offs
Authors: Almeida Fernando , Cunha Eugénio
Published: November 2018

Universities have assumed an increasingly important role in transferring technology to society with a strong economic impact. The companies originated from the academic environment, called academic spin-offs, have fostered the appearance of new projects based on emerging technologies and knowledge, created by young students and researchers who seek to launch their own business and generate new jobs in society. However, the number of existing studies on academic spin-offs is limited and restricted to the specific national realities, and the results of these studies are typically incorporated only in scientific manuscripts. In this sense, this study proposes a web platform that allows the analysis of academic spin-offs according to multiple dimensions, such as firm, institutions, individual, localization, science parks, financial data and corporate actions. The application is built exclusively in open source technologies and allows data to be explored in real-time and interactively. The results obtained allow us to evaluate the behavior of the application regarding fundamental elements in the success of the adoption of a Web application, such as usability, security, interoperability and portability.
Molecular Docking, Computational and Antithrombotic Studies of Novel 1,3,4-oxadiazole Derivatives
Authors: Batool Majda , Tajammal Affifa , Farhat Firdous , Verpoort Francis , Khattak Zafar A. K. , Nisa Mehr-un- , Shahid Muhammad , Ahmed Hafiz Adnan , Munawar Munawar Ali , Rahman Muhammad Zia ur. , Asim Raza Basra Muhammad
Published: November 2018

A new series of 1,3,4-oxadiazoles derivatives was synthesized, characterized and evaluated for their in vitro and in vivo anti-thrombotic activity. Compounds (3a-3i) exhibited significant clot lysis with respect to negative control and reference drug streptokinase (30,000 IU) while enhanced clotting time (CT) values were observed (130-342 sec) for these tested compounds than the standard drug heparin (110 sec.). High affinity towards 1NFY with greater docking score was observed for the compounds (3a, 3i, 3e, 3d and 3h) than the control ligand RPR200095. In addition, very good inhibitory potential against factor Xa (F-Xa) was observed with higher docking scores (5612-6270) with ACE values (–189.68 to –352.28 kcal/mol) than the control ligand RPR200095 (Docking score 5192; ACE –197.81 kcal/mol. In vitro, in vivo and in silico results proposed that these newly synthesized compounds can be used as anti-coagulant agents.
Bone Marrow-Derived Cellular Therapies in Orthopaedics
Authors: Piuzzi Nicolas S. , Mantripragada Venkata P. , Sumski Alan , Selvam Selvaanish , Boehm Cynthia , Muschler George F.
Published: November 2018

* Bone marrow is a valuable source of cells for cell-based therapies in orthopaedics.

* Bone marrow aspiration is most frequently performed from the iliac crest and has been reported to be a safe procedure, with a low complication rate in orthopaedics.

* The bone marrow aspiration site, technique, and subsequent processing have a profound effect on the concentration and prevalence of connective tissue progenitors. The iliac crest generally provides the highest yield and prevalence of connective tissue progenitors.

* Small aspiration volumes (1 to 2 mL each), using 10-mL syringes, and modifying the aspiration sites by 5 to 10 mm are recommended to optimize the yield of connective tissue progenitors during bone marrow aspiration.

* In clinical trials of cell-based therapies derived from bone marrow aspiration, the aspiration technique (site, needle, syringe, aspiration volume, and anticoagulant, if used) should be reported.
IN MEMORIAN S.I. VOZDVIZHENSKY
Authors: Editorial Article
Published: November 2018

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MODERN METHODS OF FETAL ANTENATAL DIAGNOSTICS AND THEIR SIGNIFICANCE FOR THE SUBSEQUENT CHILD DEVELOPMENT
Authors: Kazantseva N. V. , Izranov V. A. , Shevtsova O. A. , Shotik Yu. V.
Published: November 2018

The fetal neurobehaviour helps to evaluate the integrativity of the brain function. The distinctive signs of the fetal motor patterns allow us to diagnose developmental disorders at early stages.

The purposeis to review literature related to the study of the integrative activity of the central nervous system, the development and use of modern methods of fetal neuropsychological ultrasound diagnostics - the antenatal test of neurodevelopment after A. Kurjak (Kurjak Antenatal Neurodevelopmental Test - KANET).

The results and conclusion.Using ultrasound of pregnant women at different gestation periods helps us to directly observe and evaluate fetal movements reflecting activity of the maturing central nervous system. The KANET test based on the observation of the fetal motor pattern according to the Prechtl’s method allows us to evaluate the fetal motor activity and predict development and functioning of the central nervous system after birth. The fetal antenatal neuropsychological diagnostics is used for timely detection of the disorders of central nervous system and early implementation of preventive and curative measures for the consequences of CNS damage: neurological, emotional and behavioral disorders in older children.
AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE IN THE STRUCTURE OF CYSTIC DYSPLASIA IN CHILDREN
Authors: Makarova T. P. , Bulatov V. P. , Samoylova N. V. , Samoylova G. M. , Poladova L. V. , Cherezova I. N. , Melnikova Yu. S.
Published: November 2018

Cystic dysplasia is a heterogeneous group of diseases, with 12–15% share in the structure of congenital kidney anomalies and 8–10% share in the structure of the causes of chronic renal failure in children. The article presents the results of observation of patients with polycystic kidney disease. To study the clinical features of the course of various forms of cystic dysplasia in children we analyzed the histories of children with autosomal recessive and autosomal dominant polycystic kidney disease. We revealed clinical, laboratory and instrumental features of the course of various types of cystic renal dysplasia.
ANALYSIS OF CAUSES OF DEVELOPING COMPLICATED FORMS OF ACUTE OTITIS MEDIA IN CHILDREN
Authors: Krasnozhen V. N. , Andreeva I. G. , Mamleev R. N. , Evdokimova A. D.
Published: November 2018

The complicated course of acute otitis media in children not vaccinated against Streptococcus pneumoniae is progressively increasing. Up to 95% of children suffer at least one episode of acute otitis media during the first 7 years of life. Complications of this disease become a heavy burden for both patients, often leading to disability, and healthcare in general. The errors in antibiotic therapy of acute otitis media at the outpatient stage continue to be a serious problem. We present an analysis of the complications of acute otitis media in children and demonstrate the ways of solving this difficult problem.
TOPICAL QUESTIONS OF MEDICAL AND BIOLOGICAL SUPPORT OF CHILDREN’S AND YOUTH SPORTS
Authors: Rylova N. V. , Biktimirova A. A. , Imamov A. A. , Zholinsky A. V.
Published: November 2018

An effective system of children’s and youth sports, selection and preparation of a the reserve for national teams predetermines the success of athletes in international competitions. Therefore, the development of medical and biological support of children’s sports is an important part of sports medicine. It is proved that when building a training process for different ages, it is necessary to take into account the adaptation processes, as well as the energy supply of the child’s organism. Based on numerous studies, we can conclude that mitochondria play the most important role in the process of energy supply, as well as carnitine, a substance that is a carrier of long chain fatty acids into the cytosol, an activator of beta oxidation and the Krebs cycle. Timely detection of factors adversely affecting and limiting physical activity at the macro level (overtraining, incompatibility of physical activity with the body capabilities) and at the micro level (carnitine deficiency), the ability to eliminate these factors and the adequate use of correction tools help to achieve high results in sports and preserve the health of the athlete.
PARTICIPATION OF VITAMIN D IN PATHOGENESIS OF CARDIOVASCULAR DISEASES
Authors: Kolesnikov A. N. , Dubovaya A. V. , Udovitchenko Yu. V.
Published: November 2018

The article presents data of experimental and clinical studies devoted to the influence of vitamin D on the origin and progression of the cardiovascular diseases: arterial hypertension, atherosclerosis, coronary heart disease, cardiac rhythm disturbances. The results of the studies indicate that a pronounced deficiency of vitamin D is highly correlated with sudden cardiac death, cardiovascular catastrophes, and overall mortality. The decrease in vitamin D is followed by an increase in total cholesterol, low-density lipoproteins and triglycerides, an increase in the heart rate and the level of systolic blood pressure. The Meta-analyzes of randomized controlled trials demonstrated that the addition of vitamin D to treatment and rehabilitation measures of the patients with cardiovascular disease helps to reduce overall mortality.
SIGNIFICANCE OF THE SPHINGOMYELIN CHANGES IN CORD BLOOD LYMPHOCYTES FOR THE ACTIVITY OF CENTRAL NERVOUS SYSTEM IN PRETERM NEWBORNS
Authors: Fefelova V. V. , Lisihina N. V. , Manchuk V. T. , Ovcharenko E. S. , Koloskova Т. P. , Kovalevskaya O. I.
Published: November 2018

Abstract.Different neuropsychical pathologies are revealed in preterm infants during the subsequent stages of ontogenesis. Violation of the phospholipids composition of cell membranes is one of the essential pathogenetic mechanisms of the psychoneurological pathology.Objective:to study the content of phospholipid fractions of cord blood lymphocytes in preterm infants at different gestation terms.The spectrumof phospholipids was determined by thin layer chromatography in 39 healthy full-term newborns and in 65 preterm children (28-36 weeks). We revealed an increased content of sphingomyelin in cord blood lymphocytes in preterm infants. The highest rates were found in children with a gestation term of less than 32 weeks (p = 0.004 compared with full-term infants). Sphingomyelin, unlike other phospholipids of cell membranes, is concentrated mainly in the brain, which indicates its special role for CNS activity.Recently, there has been formed the idea on the importance of lipid components of fat globule membranes of breast milk for optimal neurological development of children. Given the changes in the sphingomyelin content in the cell membranes of preterm newborns and its important structural and functional role for CNS activity, we believe that special attention should be paid to its content in the formulas for preterm infants among standard components.
A green dispersive liquid phase microextraction technique based on the solidification of switchable hydrophilic fatty acid for determination of polynuclear aromatic hydrocarbons in aqueous samples
Authors: Hosseininejad Mahsa Sadat , Faraji Hakim , Jamshidi Ahmad
Published: November 2018

A green dispersive liquid phase microextraction approach based on the solidification of switchable hydrophilic fatty acid as an extraction phase has been developed for the determination of 16 priority polynuclear aromatic hydrocarbons (PAHs) in aqueous samples. In this study, the centrifugation step was omitted by the applying salting-out phenomenon. The influence of main variables on the efficiency of the procedure was studied by chemometric methods. Under optimal conditions, the completion time for extraction was less than 1 min, and the detector response was linear in the range of 0.1–250 μg L−1. Limit of detection and limit of quantitation were estimated as the concentration range of 0.01–0.14 μg L−1 and 0.03–0.47 μg L−1, respectively. The precision consists of repeatability and reproducibility, which were determined by calculating the relative standard deviation percent; their values were less than 7.2% and 10.5%, respectively. Applicability of the developed procedure was successfully evaluated for the analysis of PAHs in different water samples.
Sportcivilek-támogatások és összefüggések
Authors: Szabados György Norbert , Bácsné Bába Éva , Fenyves Veronika , Bács Zoltán , Dajnoki Krisztina , Kovács Sándor
Published: November 2018

Amennyiben ma civil szervezetekről, különösen sportcivil szervezetekről beszélünk, úgy érdemes amellett a jelenség mellett megállni, hogy vajon ez a szervezeti típus mennyire alkalmas és képes támogatások fogadására. A KSH vonatkozó statisztikai adatai a nonprofit szervezetek szféráján belül mutatnak rá arra a jelenségre, hogy a klasszikus civil szervezetek bevételeinek többsége évek óta magán vagy állami jellegű támogatásokból származik. Noha egy igencsak kiszámítható állami támogatási rendszer jellemzi manapság a szféra működését, melyben egyrészt igen egyenlőtlen az egyes támogatási formák eloszlása, másrészt viszont igen jelentős forrásbevonást tesz lehetővé. Az, hogy a támogatási formáknak és a támogatási bevételnek milyen összefüggése van a szervezet működésének további változóival, így például a nyújtott támogatásokkal, foglalkoztatottsági viszonyokkal, ráfordításokkal különösen jelentőséget kaphat mind a szervezetek működésének menedzselése, mind pedig a civil szféra terén történő stratégiai beavatkozások terén.