bluuebunny/crossref_metadata_2025 huggingface dataset:
Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer
Authors: Castro-Oropeza Rosario , Vazquez-Santillan Karla , Díaz-Gastelum Claudia , Melendez-Zajgla Jorge , Zampedri Cecilia , Ferat-Osorio Eduardo , Rodríguez-González Arturo , Arriaga-Pizano Lourdes , Maldonado Vilma
Published: August 2020

Epidemiological studies indicate that obesity negatively affects the progression and treatment of cervical-uterine cancer. Recent evidence shows that a subpopulation of adipose-derived stem cells can alter cancer properties. In the present project, we described for the first time the impact of adipose-derived stem cells over the malignant behavior of cervical cancer cells. The transcriptome of cancer cells cultured in the presence of stem cells was analyzed using RNA-seq. Changes in gene expression were validated using digital-PCR. Bioinformatics tools were used to identify the main transduction pathways disrupted in cancer cells due to the presence of stem cells. In vitro and in vivo assays were conducted to validate cellular and molecular processes altered in cervical cancer cells owing to stem cells. Our results show that the expression of 95 RNAs was altered in cancer cells as a result of adipose-derived stem cells. Experimental assays indicate that stem cells provoke an increment in migration, invasion, angiogenesis, and tumorigenesis of cancer cells; however, no alterations were found in proliferation. Bioinformatics and experimental analyses demonstrated that the NF-kappa B signaling pathway is enriched in cancer cells due to the influence of adipose-derived stem cells. Interestingly, the tumor cells shift their epithelial to a mesenchymal morphology, which was reflected by the increased expression of specific mesenchymal markers. In addition, stem cells also promote a stemness phenotype in the cervical cancer cells. In conclusion, our results suggest that adipose-derived stem cells induce cervical cancer cells to acquire malignant features where NF-kappa B plays a key role.
Newly identified Gon4l/Udu-interacting proteins implicate novel functions
Authors: Tsai Su-Mei , Chu Kuo-Chang , Jiang Yun-Jin
Published: August 2020

Mutations of the Gon4l/udu gene in different organisms give rise to diverse phenotypes. Although the effects of Gon4l/Udu in transcriptional regulation have been demonstrated, they cannot solely explain the observed characteristics among species. To further understand the function of Gon4l/Udu, we used yeast two-hybrid (Y2H) screening to identify interacting proteins in zebrafish and mouse systems, confirmed the interactions by co-immunoprecipitation assay, and found four novel Gon4l-interacting proteins: BRCA1 associated protein-1 (Bap1), DNA methyltransferase 1 (Dnmt1), Tho complex 1 (Thoc1, also known as Tho1 or HPR1), and Cryptochrome circadian regulator 3a (Cry3a). Furthermore, all known Gon4l/Udu-interacting proteins—as found in this study, in previous reports, and in online resources—were investigated by Phenotype Enrichment Analysis. The most enriched phenotypes identified include increased embryonic tissue cell apoptosis, embryonic lethality, increased T cell derived lymphoma incidence, decreased cell proliferation, chromosome instability, and abnormal dopamine level, characteristics that largely resemble those observed in reported Gon4l/udu mutant animals. Similar to the expression pattern of udu, those of bap1, dnmt1, thoc1, and cry3a are also found in the brain region and other tissues. Thus, these findings indicate novel mechanisms of Gon4l/Udu in regulating CpG methylation, histone expression/modification, DNA repair/genomic stability, and RNA binding/processing/export.
Novel research on nanocellulose production by a marine Bacillus velezensis strain SMR: a comparative study
Authors: Abouelkheir Samia S. , Kamara Marwa S. , Atia Salma M. , Amer Sara A. , Youssef Marina I. , Abdelkawy Rana S. , Khattab Sherine N. , Sabry Soraya A.
Published: August 2020

Bacterial nanocellulose (BNC) is a nanofibrillar polymer that possesses unique characteristics such as high chemical purity, mechanical strength, flexibility, and absorbency. In addition, different bacterial strains can form nanocellulose (NC) in multiple shapes and sizes. This study describes the first report of a marine Bacillus strain that is able to synthesize NC. The strain identified as B. velezensis SMR based on 16S rDNA sequencing, produced highly structured NC, as confirmed by X-ray diffraction (XRD) and Scanning Electron Microscopic Analysis (SEM). In Hestrin-Schramm (HS) medium, B. velezensis SMR produced twice the quantity of BNC in comparison to the reference strain, G. xylinus ATCC 10245. The ability of B. velezensis SMR to produce NC using different industrial waste materials as growth media was tested. Growth in Ulva seaweed extract supported a 2.5-fold increase of NC production by B. velezensis SMR and a threefold increase in NC production by G. xylinus ATCC 10245. As proof of principle for the usability of NC from B. velezensis SMR, we successfully fabricated a BNC-based polyvinyl alcohol hydrogel (BNC-PVA) system, a promising material used in different fields of application such as medicine, food, and agriculture.
Author Correction: Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model
Authors: Zehra Meraj , Mushtaq Shamim , Ghulam Musharraf Syed , Ghani Rubina , Ahmed Nikhat
Published: August 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Cold damage from wax deposition in a shallow, low-temperature, and high-wax reservoir in Changchunling Oilfield
Authors: Xie Jun , Hu Xiao , Liang Hui-zhen , Wang Meng-qi , Guo Fa-jun , Zhang Shu-juan , Cai Wu-chao , Wang Rui
Published: August 2020

Wax deposition is an important factor that influences oil production for high-wax crude oilfield. There are few studies on the formation damage by wax deposition, especially cold damage to the shallow low-temperature reservoir. With laboratory tests conducted on reservoir oil and cores of Changchunling Oilfield, this study aims to experimentally investigate the influence of temperature variations on characteristics of oil–water percolation and cold damage mechanisms, as well as the relative permeability of high-wax reservoirs. Experimental results show that seepage flow of high-wax crude is significantly sensitive to temperature-wax deposition evidently increases, whereas the cold damage such as the pore-throat radius and relative permeability sharply decrease with the decline in formation temperature. The research results can be applied to enhance oil recovery of high-viscosity or high-wax oilfields.
Assessing haemorrhage-critical values of cerebral blood flow by modelling biomechanical stresses on capillaries in the immature brain
Authors: Sidorenko Irina , Turova Varvara , Botkin Nikolai , Kovtanyuk Andrey , Eckardt Laura , Alves-Pinto Ana , Felderhoff-Müser Ursula , Rieger-Fackeldey Esther , Lampe Renée
Published: August 2020

The development of intraventricular haemorrhages (IVH) in preterm newborns is triggered by a disruption of the vessels responsible for cerebral microcirculation. Analysis of the stresses exerted on vessel walls enables the identification of the critical values of cerebral blood flow (CBF) associated with the development of IVH in preterm infants. The purpose of the present study is the estimation of these critical CBF values using the biomechanical stresses obtained by the finite element modelling of immature brain capillaries. The properties of the endothelial cells and basement membranes employed were selected on the basis of published nanoindentation measurements using atomic force microscopes. The forces acting on individual capillaries were derived with a mathematical model that accounts for the peculiarities of microvascularity in the immature brain. Calculations were based on clinical measurements obtained from 254 preterm infants with the gestational age ranging from 23 to 30 weeks, with and without diagnosis of IVH. No distinction between the affected and control groups with the gestational age of 23 to 26 weeks was possible. For infants with the gestational age of 27 to 30 weeks, the CBF value of 17.03 ml/100 g/min was determined as the critical upper value, above which the likelihood of IVH increases.
Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila
Authors: Lu Yubing , West Ryan J. H. , Pons Marine , Sweeney Sean T. , Gao Fen-Biao
Published: August 2020

Mutations in CHMP2B, encoding a protein in the endosomal sorting complexes required for transport (ESCRT) machinery, causes frontotemporal dementia linked to chromosome 3 (FTD3). FTD, the second most common form of pre-senile dementia, can also be caused by genetic mutations in other genes, including TANK-binding kinase 1 (TBK1). How FTD-causing disease genes interact is largely unknown. We found that partial loss function of Ik2, the fly homologue of TBK1 also known as I-kappaB kinase ε (IKKε), enhanced the toxicity of mutant CHMP2B in the fly eye and that Ik2 overexpression suppressed the effect of mutant CHMP2B in neurons. Partial loss of function of Spn-F, a downstream phosphorylation target of Ik2, greatly enhanced the mutant CHMP2B phenotype. An interactome analysis to understand cellular processes regulated by Spn-F identified a network of interacting proteins including Spn-F, Ik2, dynein light chain, and Hook, an adaptor protein in early endosome transport. Partial loss of function of dynein light chain or Hook also enhanced mutant CHMP2B toxicity. These findings identify several evolutionarily conserved genes, including ik2/TBK1, cut up (encoding dynein light chain) and hook, as genetic modifiers of FTD3-associated mutant CHMP2B toxicity and implicate early endosome transport as a potential contributing pathway in FTD.
The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation
Authors: Shimada Masaru , Yamashita Akio , Saito Manami , Ichino Motohide , Kinjo Takao , Mizuki Nobuhisa , Klinman Dennis M. , Okuda Kenji
Published: August 2020

Oncoprotein E6 of high-risk human papillomavirus (HPV) plays a critical role in inducing cell immortalization and malignancy. E6 downregulates caspase-dependent pathway through the degradation of p53. However, the effect of HPV E6 on other pathways is still under investigation. In the present study, we found that HPV E6 directly binds to all three forms (precursor, mature, and apoptotic) of apoptosis-inducing factor (AIF) and co-localizes with apoptotic AIF. This binding induced MG132-sensitive reduction of AIF expression in the presence of E6 derived from HPV16 (16E6), a cancer-causing type of HPV. Conversely, E6 derived from a non-cancer-causing type of HPV, HPV6 (6E6), did not reduce the levels of AIF despite its interaction with AIF. Flow cytometric analysis revealed that 16E6, but not 6E6, suppressed apoptotic AIF-induced chromatin degradation (an indicator of caspase-independent apoptosis) and staurosporine (STS, a protein kinase inhibitor)-induced apoptosis. AIF knockdown reduced STS-induced apoptosis in both of 16E6-expressing and 6E6-expressing cells; however, the reduction in 16E6-expressing cells was lower than that in 6E6-expressing cells. These findings indicate that 16E6, but not 6E6, blocks AIF-mediated apoptosis, and that AIF may represent a novel therapeutic target for HPV-induced cervical cancer.
Intraoperative high-resolution esophageal manometry during peroral endoscopic myotomy
Authors: Barret Maximilien , Guillaumot Marie-Anne , Leandri Chloé , Leblanc Sarah , Coriat Romain , Belle Arthur , Chaussade Stanislas
Published: August 2020

Peroral endoscopic myotomy is an accepted treatment of achalasia. Some of the treatment failures can be attributable to an insufficient length of the myotomy on the gastric side, because of a more technically challenging submucosal dissection. We assessed the feasibility and the impact of an intraoperative esophageal manometry during the peroral endoscopic myotomy procedure. A high-resolution manometry catheter was introduced through the nostril before the endoscope, and left in place during the peroral endoscopic myotomy procedure. The lower esophageal sphincter pressure was recorded throughout the peroral endoscopic myotomy. The myotomy was extended on the gastric side until the lower esophageal sphincter pressure dropped below 10 mmHg. We included 10 patients (mean age = 55 years old, 3 men) treated by peroral endoscopic myotomy for type I (3/10), type II (3/10), type III achalasia (3/10) or esophagogastric junction outflow obstruction (1/10). Manometric recording was possible in all patients. The median (IQR) lower esophageal sphincter resting pressure was 23 (17–37) mmHg before myotomy, 15 (13–19) mmHg at the end of the tunnel, and 7 (6–11) mmHg at the end of the myotomy. In 4 patients out of 10, the myotomy was extended on the base of the intraoperative manometry findings. High-resolution esophageal manometry is feasible during the peroral endoscopic myotomy procedure, and leads to increase the length of the gastric myotomy in 4 out of 10 patients. However, the cumbersome nature of intraoperative high-resolution manometry during peroral endoscopic myotomy and the high frequency of gastro-esophageal reflux disease after extended gastric myotomy suggest to limit this technique to selected patients refractory to a first myotomy.
On the instability of the giant direct magnetocaloric effect in CoMn0.915Fe0.085Ge at. % metamagnetic compounds
Authors: Bruno N. M. , Yuce S.
Published: August 2020

The giant magnetocaloric effect was quantified in CoMn1-xFexGe (x = 0.085–0.12) nom. at. % polycrystals across the high temperature hexagonal (P63/mmc) to low temperature orthorhombic (Pnma) phase transition via differential scanning calorimetry (DSC) and multiple (thermo) magnetization measurements. It was found that increasing Fe content led to the decrease of both the martensitic transformation temperature and entropy change ($$\Delta S$$

Δ
S

) at the point of the phase transition. Moreover, first-time magnetocaloric measurements resulted in irreproducible entropy change versus temperature diagrams, which was attributed to the release of internal pressure in bulk samples that disintegrated into powder upon transformation. CoMn1-xFexGe demonstrated larger magnetic field-induced entropy changes and giant magnetocaloric effect (MCE) compared to other CoMnGe alloys doped with Si, Sn, Ti, and Ga. However, the observed brittleness and apparent change in volume at the magnetic transition was posited to influence the material’s potential for regenerative applications.
Downscaling global ocean climate models improves estimates of exposure regimes in coastal environments
Authors: Fagundes Matheus , Litvin S. Y. , Micheli F. , De Leo G. , Boch C. A. , Barry J. P. , Omidvar S. , Woodson C. B.
Published: August 2020

Climate change is expected to warm, deoxygenate, and acidify ocean waters. Global climate models (GCMs) predict future conditions at large spatial scales, and these predictions are then often used to parameterize laboratory experiments designed to assess biological and ecological responses to future change. However, nearshore ecosystems are affected by a range of physical processes such as tides, local winds, and surface and internal waves, causing local variability in conditions that often exceeds global climate models. Predictions of future climatic conditions at local scales, the most relevant to ecological responses, are largely lacking. To fill this critical gap, we developed a 2D implementation of the Regional Ocean Modeling System (ROMS) to downscale global climate predictions across all Representative Concentration Pathway (RCP) scenarios to smaller spatial scales, in this case the scale of a temperate reef in the northeastern Pacific. To assess the potential biological impacts of local climate variability, we then used the results from different climate scenarios to estimate how climate change may affect the survival, growth, and fertilization of a representative marine benthic invertebrate, the red abalone Haliotis rufescens, to a highly varying multi-stressor environment. We found that high frequency variability in temperature, dissolved oxygen (DO), and pH increases as pCO2 increases in the atmosphere. Extreme temperature and pH conditions are generally not expected until RCP 4.5 or greater, while frequent exposure to low DO is already occurring. In the nearshore environment simulation, strong RCP scenarios can affect red abalone growth as well as reduce fertilization during extreme conditions when compared to global scale simulations.
Characterization and analysis of full-length transcriptomes from two grasshoppers, Gomphocerus licenti and Mongolotettix japonicus
Authors: Yuan Hao , Zhang Xue , Zhao Lina , Chang Huihui , Yang Chao , Qiu Zhongying , Huang Yuan
Published: August 2020

Acrididae are diverse in size, body shape, behavior, ecology and life history; widely distributed; easy to collect; and important to agriculture. They represent promising model candidates for functional genomics, but their extremely large genomes have hindered this research; establishing a reference transcriptome for a species is the primary means of obtaining genetic information. Here, two Acrididae species, Gomphocerus licenti and Mongolotettix japonicus, were selected for full-length (FL) PacBio transcriptome sequencing. For G. licenti and M. japonicus, respectively, 590,112 and 566,165 circular consensus sequences (CCS) were generated, which identified 458,131 and 428,979 full-length nonchimeric (FLNC) reads. After isoform-level clustering, next-generation sequencing (NGS) short sequences were used for error correction, and remove redundant sequences with CD-HIT, 17,970 and 16,766 unigenes were generated for G. licenti and M. japonicus. In addition, we obtained 17,495 and 16,373 coding sequences, 1,082 and 813 transcription factors, 11,840 and 10,814 simple sequence repeats, and 905 and 706 long noncoding RNAs by analyzing the transcriptomes of G. licenti and M. japonicus, respectively, and 15,803 and 14,846 unigenes were annotated in eight functional databases. This is the first study to sequence FL transcriptomes of G. licenti and M. japonicus, providing valuable genetic resources for further functional genomics research.
Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms
Authors: Ali Amanat , Vijayan Ranjit
Published: August 2020

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major public health concern. A handful of static structures now provide molecular insights into how SARS-CoV-2 and SARS-CoV interact with its host target, which is the angiotensin converting enzyme 2 (ACE2). Molecular recognition, binding and function are dynamic processes. To evaluate this, multiple 500 ns or 1 μs all-atom molecular dynamics simulations were performed to better understand the structural stability and interfacial interactions between the receptor binding domain of the spike (S) protein of SARS-CoV-2 and SARS-CoV bound to ACE2. Several contacts were observed to form, break and reform in the interface during the simulations. Our results indicate that SARS-CoV-2 and SARS-CoV utilizes unique strategies to achieve stable binding to ACE2. Several differences were observed between the residues of SARS-CoV-2 and SARS-CoV that consistently interacted with ACE2. Notably, a stable salt bridge between Lys417 of SARS-CoV-2 S protein and Asp30 of ACE2 as well as three stable hydrogen bonds between Tyr449, Gln493 and Gln498 of SARS-CoV-2 and Asp38, Glu35 and Lys353 of ACE2 were observed, which were absent in the ACE2–SARS-CoV interface. Some previously reported residues, which were suggested to enhance the binding affinity of SARS-CoV-2, were not observed to form stable interactions in these simulations. Molecular mechanics-generalized Born surface area based free energy of binding was observed to be higher for SARS-CoV-2 in all simulations. Stable binding to the host receptor is crucial for virus entry. Therefore, special consideration should be given to these stable interactions while designing potential drugs and treatment modalities to target or disrupt this interface.
A one-step mild acid route to fabricate high performance porous anti-reflective optical films from cationic polymeric nanolatex
Authors: Zhang Tong , Jia Jiannan , Xiao Yao , Shen Binhua , Wang Zhiyong , Yi Xiaosu , Qiao Xvsheng , Zhao Yan
Published: August 2020

Porous silica anti-reflection (AR) films are of importance in solar cells’ photon harvest. However, the usual utilized method to fabricate AR films is the two-step method since the formation of porous silica NPs (first step) and silica coating sol (second step) always require chemical systems at distinct pH values. To reduce the complexity of the process, we choose cationic emulsion as an approach to produce the porosity and propose a convenient one-step route to get high-performance antireflective films. A single layer SiO2 anti-reflective (AR) film with high optical transmittance up to 97.5% at 740 nm was fabricated from composite sol that was made from cationic emulsion nanolatex and tetraethylorthosilicate under acid catalysis condition. After calcination, the transmittance of AR coated glasses still held the transmittance of 96% at 550 nm. Composited with SiO2, Al2O3, or TiO2 sol binders, the transmittance of AR coated glasses could be recovered as high as 97.9% at 650 nm and the pencil hardness was further strengthened up to 6H. The composite sol can keep stable at least one month at ambient temperature without any visible precipitation. Therefore, the proposed method is promising for developing high-performance AR films effectively and economically.
Survival and regeneration ability of clonal common milkweed (Asclepias syriaca L.) after a single herbicide treatment in natural open sand grasslands
Authors: Bakacsy László , Bagi István
Published: August 2020

Invasive species are a major threat to biodiversity, human health, and economies worldwide. Clonal growth is a common ability of most invasive plants. The clonal common milkweedAsclepias syriacaL. is the most widespread invasive species in Pannonic sand grasslands. Despite of being an invader in disturbed semi-natural vegetation, this plant prefers agricultural fields or plantations. Herbicide treatment could be one of the most cost-effective and efficient methods for controlling the extended stands of milkweed in both agricultural and protected areas. The invasion of milkweed stand was monitored from 2011 to 2017 in a strictly protected UNESCO biosphere reserve in Hungary, and a single herbicide treatment was applied in May 2014. This single treatment was successful only in a short-term but not in a long-term period, as the number of milkweed shoots decreased following herbicide treatment. The herbicide translocation by rhizomatic roots induced the damage of dormant bud banks. The surviving buds developing shoots, growth of the milkweed stand showed a slow regeneration for a longer-term period. We concluded that the successful control of milkweed after herbicide treatment depends on repeated management of treated areas to suppress further spreading during subsequent seasons.
Quantum dots as nanosensors for detection of toxics: a literature review
Authors: Ganesan Muthupandian , Nagaraaj Paramathevar
Published: August 2020

Photoluminescence enhancement of QDs upon interaction with analyte.
Liquid exfoliated biocompatible WS2@BSA nanosheets with enhanced theranostic capacity
Authors: Yi Haoyang , Zhou Xinyue , Zhou Chaohui , Yang Qingye , Jia Nengqin
Published: August 2020

Ultrathin transition metal dichalcogenides (TMDs) seem to have a promising future in the field of theranostic agents due to their excellent near-infrared light absorption capacity and large specific surface area.
Targeting G-quadruplex structures with Zn(ii) terpyridine derivatives: a SAR study
Authors: Busto Natalia , Carrión M. Carmen , Montanaro Sonia , Díaz de Greñu Borja , Biver Tarita , Jalón Felix A. , Manzano Blanca R. , García Begoña
Published: August 2020

A family of Zn(ii) terpyridine derivatives with different leaving groups and 4′-substituents was synthesized. A SAR study in terms of cytotoxicity and thermal stabilization of G-quadruplex structures is presented.
Cu(i) complexes obtainedviaspontaneous reduction of Cu(ii) complexes supported by designed bidentate ligands: bioinspired Cu(i) based catalysts for aromatic hydroxylation
Authors: Kumari Sheela , Muthuramalingam Sethuraman , Dhara Ashish Kumar , Singh U. P. , Mayilmurugan Ramasamy , Ghosh Kaushik
Published: August 2020

Cu(i) complexes were synthesizedviaspontaneous reduction and X-ray crystal structure of complex1was determined. Direct hydroxylation of benzene to phenol afforded selectivity up to 98%. KIE values of 1.69–1.71 supported radical based mechanism.
Graphene oxide sponge as adsorbent for organic contaminants: comparison with granular activated carbon and influence of water chemistry
Authors: Allgayer Raphaela , Yousefi Nariman , Tufenkji Nathalie
Published: August 2020

A graphene oxide sponge with hierarchical porosity outperforms Norit GAC for removal of methylene blue.
Correction: Automated determination of n-cyanobiphenyl and n-cyanobiphenyl binary mixtures elastic constants in the nematic phase from molecular simulation
Authors: Shi Jiale , Sidky Hythem , Whitmer Jonathan K.
Published: August 2020

Correction for ‘Automated determination of n-cyanobiphenyl and n-cyanobiphenyl binary mixtures elastic constants in the nematic phase from molecular simulation’ by Jiale Shi et al., Mol. Syst. Des. Eng., 2020, 5, 1131–1136, DOI: 10.1039/C9ME00065H.
Coulomb barrier creation by means of electronic field emission in nanolayer capacitors
Authors: Ilin Eduard , Burkova Irina , Draher Timothy , Colla Eugene V. , Hübler Alfred , Bezryadin Alexey
Published: August 2020

Electrons tunnel from the cathode into the dielectric, get trapped on defects and build up a volume charge. These immobilized electrons generate an addition barrier, the Coulomb barrier, which reduces the leakage current of the nanocapacitor.
Vinyl-addition polymerizations of cycloallenes: synthetic access to congeners of cyclic-olefin polymers
Authors: Galan Nicholas J. , Burroughs Justin M. , Maroon Christopher R. , Long Brian K. , Brantley Johnathan N.
Published: August 2020

Vinyl-addition polymerizations of cyclic allenes were investigated. Copolymers of cyclic and acyclic allenes were prepared, and the impact of cycloallene feed ratio on bulk material properties was explored.
Pyrene-based metallocycles and metallocages: more than fluorophores
Authors: Wang Xu-Qing , Ling Qing-Hui , Wang Wei , Xu Lin
Published: August 2020

This review comprehensively summarizes the construction of pyrene-based metallocycles and metallocages as well as their properties and applications.
Electron/energy co-transfer behavior and reducibility of Cu-chlorophyllin-bonded carbon-dots
Authors: Ji Tian-Hao , Li Xue-Li , Mao Yongyun , Mei Zhipeng , Tian Yanqing
Published: August 2020

Cu-chlorophyllin-bonded carbon dots (CCPh-CDs) with/without Ag/Ag2O (CCPh-CD-Ag) were obtained and investigated by optical measurements and luminescence decay spectroscopy.
The flow limiting operator: a new approach to environmental control in flow bioreactors
Authors: Horbatiuk Jeffrey , Alazzawi Lubna , Harris Carolyn A.
Published: August 2020

FLO is a high-throughput bioreactor for testing biomaterials in more physiologically similar environments including pulsation amplitude, flow rate, and pressure waveforms which is done through the manipulation of fluid velocity.
An expeditious click approach towards the synthesis of galactose coated novel glyco-dendrimers and dentromers utilizing a double stage convergent method
Authors: Agrahari Anand K. , Singh. Anoop S. , Mukherjee Rishav , Tiwari Vinod K.
Published: August 2020

A proficient double stage convergent approach has been exploited for an easy access of galactose coated novel glycodendrimers and dentromers under CuAAC click condition.
Electrochemical study of 4-chloroaniline in a water/acetonitrile mixture. A new method for the synthesis of 4-chloro-2-(phenylsulfonyl)aniline and N-(4-chlorophenyl)benzenesulfonamide
Authors: Mohamadighader Niloofar , Saraei Mahnaz , Nematollahi Davood , Goljani Hamed
Published: August 2020

Electrochemical oxidation pathway of p-chloroaniline (PCA) in the presence of benzenesulfinic acid (BSA).
Functionalized pyridine in pyclen-based iron(iii) complexes: evaluation of fundamental properties
Authors: Mekhail Magy A. , Pota Kristof , Schwartz Timothy M. , Green Kayla N.
Published: August 2020

Six iron(iii) pyridinophane complexes were evaluated to determine whether functionalizing the pyridine ring could introduce a handle by which electrochemical properties and thermodynamic stability can be tuned.
Visible region absorption in TMDs/phosphorene heterostructures for use in solar energy conversion applications
Authors: Maniyar Ashraf , Choudhary Sudhanshu
Published: August 2020

Heterostructures of pristine black phosphorene (P) with transition metal dichalcogenide (TMD) monolayers of MoS2, MoSe2, MoTe2, WS2, and WSe2 are investigated using density functional theory based simulations.
Human red blood cell behaviour in hydroxyethyl starch: probed by single cell spectroscopy
Authors: N Mithun , Lukose Jijo , Shastry Shamee , Mohan Ganesh , Chidangil Santhosh
Published: August 2020

Hydroxyethyl starch (HES) is a commonly used intravenous fluid in hospital settings.
Using an UPLC/MS-based untargeted metabolomics approach for assessing the antioxidant capacity and anti-aging potential of selected herbs
Authors: Salem Mohamed A. , Radwan Rasha Ali , Mostafa Eman Sherien , Alseekh Saleh , Fernie Alisdair R. , Ezzat Shahira M.
Published: August 2020

Aging is an unavoidable fate that afflicts all life, during this process in mammals, reactive oxygen species (ROS) are generated which stimulate tyrosinase, elastase and collagenase activities that actively participate in skin aging.
Facile synthesis of picenes incorporating imide moieties at both edges of the molecule and their application to n-channel field-effect transistors
Authors: Guo Yuxin , Yoshioka Kaito , Hamao Shino , Kubozono Yoshihiro , Tani Fumito , Goto Kenta , Okamoto Hideki
Published: August 2020

Picenediimide derivatives serve as the active layer of n-channel thin-film field-effect transistors displaying a maximum charge carrier mobility as high as 2.0 × 10−1 cm2 V−1 s−1.
Quantum-confined superfluid reactions
Authors: Hao Yuwei , Pang Shuai , Zhang Xiqi , Jiang Lei
Published: August 2020

The concept of quantum-confined superfluid reactions is introduced into artificial systems, which is expected to be useful in future chemical engineering.
Fabrication of a 2.8 V high-performance aqueous flexible fiber-shaped asymmetric micro-supercapacitor based on MnO2/PEDOT:PSS-reduced graphene oxide nanocomposite grown on carbon fiber electrode
Authors: Naderi Leila , Shahrokhian Saeed , Soavi Francesca
Published: August 2020

Flexible and lightweight fiber-shaped micro-supercapacitors have attracted tremendous attention as next-generation portable electronic devices, due to their high flexibility, tiny volume, and wearability.
Controllable synthesis of platinum diselenide (PtSe2) inorganic fullerene
Authors: Wang Mengjing , Shawkat Mashiyat Sumaiya , Xi Zheng , Xia Xiaohu , Lee Kyu Seung , Son Dong Ick , Bae Tae-Sung , Ryu Hyeon Ih , Chung Hee-Suk , Jung Yeonwoong
Published: August 2020

A controlled synthesis of van der Waals-assembled platinum diselenide (PtSe2) fullerenes is reported and their formation mechanism is unveiled.
An electrolyte-phobic carbon nanotube current collector for high-voltage foldable lithium-ion batteries
Authors: Mu Ke Wen , Liu Kai Xi , Wang Zhi Yong , Zanman Shahid , Yin Yan Hong , Liu Xian Bin , Li Ye Sheng , Xia Bao Yu , Wu Zi Ping
Published: August 2020

Surface/interface modification is developed to tune the electrolyte wettability of a carbon nanotube current collector for controlling the lithium ion diffusion and achieving high voltage foldable lithium-ion batteries.
Correction: Steering the crystallization of perovskites for high-performance solar cells in ambient air
Authors: Wang Feng , Zhang Ting , Wang Yafei , Liu Detao , Zhang Peng , Chen Hao , Ji Long , Chen Li , Chen Zhi David , Wu Jiang , Liu Xin , Li Yanbo , Wang Yafei , Li Shibin
Published: August 2020

Correction for ‘Steering the crystallization of perovskites for high-performance solar cells in ambient air’ by Feng Wang et al., J. Mater. Chem. A, 2019, 7, 12166–12175, DOI: 10.1039/C9TA02566A.
Correction: Identification of active sites for CO2 hydrogenation in Fe catalysts by first-principles microkinetic modelling
Authors: Han Seung Ju , Hwang Sun-Mi , Park Hae-Gu , Zhang Chundong , Jun Ki-Won , Kim Seok Ki
Published: August 2020

Correction for ‘Identification of active sites for CO2 hydrogenation in Fe catalysts by first-principles microkinetic modelling’ by Seung Ju Han et al., J. Mater. Chem. A, 2020, 8, 13014–13023, DOI: 10.1039/D0TA01634A.
A non-viral nano-delivery system targeting epigenetic methyltransferase EZH2 for precise acute myeloid leukemia therapy
Authors: Kaundal Babita , Kushwaha Avinash Chandra , Srivastava Anup Kumar , Karmakar Surajit , Choudhury Subhasree Roy
Published: August 2020

HSA-PEI nanoformulation mediated non-viral delivery of EZH2 siRNA triggers EZH2 gene silencing and control Acute Myeloid Leukemia via proteasome mediated pathway.
Shape-transformation of polymersomes from glassy and crosslinkable ABA triblock copolymers
Authors: Chidanguro Tamuka , Ghimire Elina , Simon Yoan C.
Published: August 2020

We used osmotic pressure changes to induce shape transformation in glassy polymersomes from crosslinkable ABA triblock copolymers. We observed that both the speed of osmotic pressure changes and order of crosslinking affect shape change behavior.
Facile synthesis, formation mechanism and thermochromic properties of W-doped VO2(M) nanoparticles for smart window applications
Authors: Zhang Liangmiao , Xia Fang , Yao Jianing , Zhu Tianli , Xia Hui , Yang Guang , Liu Bin , Gao Yanfeng
Published: August 2020

Tungsten-doped VO2(M) nanoparticles and films with good solar energy modulation ability were prepared by a simple hydrothermal recrystallization method and subsequent spin-coating.
Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?
Authors: Davis Jessica P.E. , Caldwell Stephen H.
Published: August 2020

Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.
Data‐driven robust extended computer‐aided harmonic power flow analysis
Authors: Nduka Onyema S. , Ahmadi Ali R.
Published: August 2020

The surge in the uptake of harmonic producing loads in 21st‐century smart distribution networks has necessitated that robust data‐driven approaches for harmonic assessment be developed. Moreover, there exists abundant harmonic data which can be leveraged on for the construction of this harmonic assessment tool. This is the objective of this study. Large volumes of time‐stamped data acquired from a practical distribution network in Edmonton, Canada, have been used to construct a time‐dependent cross‐coupled harmonic model that has been combined with a formulated iterative time‐dependent robust extended computer‐aided harmonic power flows. The constructed harmonic power flow formulation also considered the constraints relating to the power conservation principle at the fundamental frequency. Practical network conditions including untransposed lines, load unbalance and skin effects of conductors have been thoroughly modelled. The proposed method has been applied to practical radial and weakly meshed medium voltage distribution networks and it demonstrated robustness to initialisation of the iterative procedure. Moreover, findings from this detailed data‐driven technique reveal that harmonic impacts in the distribution networks depend on the quantum of harmonic levels, type of network and location of the harmonic sources.
Modelling of composite materials energy by fiber bundle model
Authors: Boufass Siham , Hader Ahmed , Tanasehte Mohammed , Sbiaai Hicham , Achik Imad , Boughaleb Yahia
Published: August 2020

In this paper, the fiber energy in composite materials, subject to an external constant load, is studied. The investigation is done in the framework of fiber bundle model with randomly oriented fibers. The charge transfer is done only between neighboring close fibers according to the local load sharing. During the breaking process, the fibers expand, increasing their elastic energy, but when the fiber breaks, it loses its link with its neighboring fibers reducing the cohesive energy of the materials. The results show that the material energy presents one maximal peak at cross over time which decreases linearly with the applied force and scales with the lifetime of the material. However, the temperature does not have a remarkable effect on the material energy variation. In addition, the link density fiber decreases exponentially with time. The characteristic time of the obtained profile decreases with the applied force. Moreover, this density decreases with applied forces according to the Lorentz law with a remarkable change at critical force value.
Soft palatal wound associated with dental avulsion: an exceptional consequence of a bovine horn blow in children
Authors: Zegbeh-N'guessan Eric Kouassi , Koné Rokiatou , Djémi Ernest Martial , Bérété Pornan Issa Jules , Irié Gohi bi Serge , Crézoit Gréberet Emmanuel
Published: August 2020

Introduction: Palatal wounds in children as a result of a bovine horn blow have rarely been observed in adults and almost never in children. They are serious and can lead to fatal complications. Dental injuries by bovine horn are also rare. Observation: This study presents the unpublished case of an 11-year-old child who developed a soft palate penetrating wound associated with traumatic loss of the lower incisors as a result of a bovine horn blow. The surgical outcomes were positive. Comment: This type of childly bovine trauma is common in rural African agricultural areas. Dental trauma probably served as a mitigator to the soft palate trauma thus avoiding an associated injury of the hard palate and a contusion of the internal carotid artery. Although, there is a consensus among practitioners on leaving palate wounds to heal spontaneously, we chose a debridement and a suture because of the severity of the wound and the potential risk of turning into an oral-nasal fistula. Conclusion: The potential severity of palate and dental damage from bovine horns should lead to dehorning of cattle for better protection of children in rural agriculture.
Ecophysiology.
Authors: Rees Paul A.
Published: August 2020

This chapter contains questions about the physiological adaptations of animals and plants to their environment.
Deformation uniformity of additively manufactured materials on the example of austenitic stainless steel 321 and copper C11000
Authors: Panfilov A , Knyazhev E , Kalashnikova T , Kalashnikov K , Nikonov S , Gusarova A
Published: August 2020

Structural studies and mechanical tests of additively manufactured samples from AISI 321 steel copper C110000 have been carried out. Mechanical tensile tests of 321 steel show slight differences in the ultimate tensile strength (up to 3-4%) and ductility (up to 10%) of test coupons tested along the material growth direction and along the layer deposition direction. The strength of C11000 copper samples is 9.4% higher in the layer deposition direction, but their ductility is 15.4% lower than that of samples deformed in the growth direction. The strain relief on the surface of the polished gage section of the steel test coupons demonstrates changes in the material structure with small elongated grains along the growth direction of the sample. The deformation relief of copper samples is mainly related to the deformation of large columnar grains stretched in the growth direction.
Influence of Substrates on Conductivity of Thin Carbon Films Deposited by Methane Plasma and Subsequent Annealed
Authors: Neustroev E P , Prokopiev A R , Popov V I
Published: August 2020

The properties of thin carbon films obtained by the deposition of carbon in CH4 - plasma on the surface of various substrates (Si, SiO2 and quartz glass) and subsequent annealing at 650 to 800 °C were investigated. The sizes of graphene domains from 5 to 15 nm from Raman spectra were determined which increases with rising temperature on synthesis of carbon films. Also, sizes of graphene domains were estimated based on the electrical conductivities of obtained carbon films, and their values were equal ∼10.8 nm. The Efros-Shklovskii variable-range hopping (ES-VRH) conduction mechanism is replaced by percolation conductivity with increasing temperature from 650 to 800° C. When using Si substrates, the hopping mechanism was not observed at all temperatures.
Influence of preceramic paper composition on microstructure and mechanical properties of spark plasma sintered Ti3SiC2-based composites
Authors: Sedanova E P , Kashkarov E B , Syrtanov M S , Abdullina K R , Mingazova Y R , Lider A M , Travitzky N
Published: August 2020

This paper describes the effect of preceramic paper composition on microstructure and mechanical properties of Ti3SiC2-based composites. The preceramic paper with Ti3SiC2-powder filler and different content (from 10 to 40 wt.%) of organic component (cellulose) was prepared. The composites were obtained by spark plasma sintering (SPS) at 50 MPa pressure for 10 min holding time. The sintering temperature was 1473 K. The influence of organic content on microstructure, phase composition, and flexural strength of the sintered materials was analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD) and mechanical testing, respectively. It was revealed that the microstructure of the sintered materials became more porous with increasing of cellulose content in the paper. XRD analysis showed the presence of Ti3SiC2, TiC and TiSi2 phases in the sintered samples while the content of the Ti3SiC2 phase increase with decreasing of the organic content. The flexural strength changes from 100 (40 wt.%) to 300 MPa (10 wt.% organic binder) that is caused by porosity of the composites.
Disordering of carbon nanotubes by ion bombardment
Authors: Stepanov A V , Popov A P , Dimitrieva A I , Kovalenko A V , Yumanov D S , Shemukhin A A , Vorobyeva E A , Elsehly Emad M
Published: August 2020

In this work, the formation of defects during the ionic modification of carbon nanotubes was studied. It was shown that during the ionic modification of multiwalled carbon nanotubes, the defect formation mechanism is reduced not only to the formation of recoil atoms by ions, but also due to the thermal peak. It can be seen that the radial distribution function for the irradiated nanotube is significantly different from the radial distribution function of a heated 4000 K nanotube. In addition, disorder has a special character: in the case of ion irradiation, in contrast to heating.
Study of the optical properties of asphaltenes of wax deposits of oil-water emulsions
Authors: Savelyeva A V , Nebogina N A , Prozorova I V , Yudina N V
Published: August 2020

In this work, based on a comprehensive analysis of the optical absorption spectra obtained by spectrophotometry in the visible region, the change in the stability of asphaltenes isolated from wax deposits of emulsions with different water contents were studied. Asphaltenes of oil-water emulsion wax deposit with a small water content are characterized by maximum values of the light absorption coefficient. Asphaltenes which characterized by maximum values of the coefficient of light absorption and more capable of aggregation form wax deposit of 10 and 30 % of water-oil emulsions. A further increase in the water content in the emulsion to 50 and 70 % leads to the fact that the values of the light absorption coefficient are reduced, i.e. wax deposit form more stable asphaltenes. The least stable asphaltenes contain a highly aromatic polar fraction, are characterized by high molecular weights and precipitate from emulsions with a small water content and minimal average droplet sizes.
Higher order fully implicit cell-centered finite volume method for simulation of oil-water displacement in porous medium
Authors: Dil D O
Published: August 2020

In this paper a fully implicit cell-centered finite volume method with Higher-Order Upwind scheme (HOU) for convective flow approximation is presented for numerical solution of oil-water displacement problem. Main advantages of this scheme are the robustness, accuracy and rapid convergence of Newton technique, used for linearization obtained discrete equations. Using of HOU scheme allows receive second order approximation of flux in the regions of slow saturation changing and stable solution near to the shocks. Efficiency of proposed scheme is verified by numerical tests.
Potentiometric determination of nickel (II) with sodium diethyldithiocarbamate (NaDEDC)
Authors: Zakharkiva A M , Shumar S V
Published: August 2020

The article presents the results of potentiometric titration of the solution containing Ni (II) by the solution of sodium diethylditheocarbamate (NaDEDC). The possibilities of carbon composite electrode (CCE) and certain ion-selective and metal electrodes as the sensors for potentiometric determination of ions were investigated. The conditions for potentiometric titration of nickel (reagent, pH, composition of supporting solution, efficient electrode, effect of interfering ions) using sensors have been studied and optimized. The titration curves were processed by the linearization method which provide determination of equivalence point with high accuracy.
Potentiometric sensor for chromium (VI) determination
Authors: Shibaev A Yu , Shelkovnikov V V , Novolokov K Yu , Anishchenko M V
Published: August 2020

The development of rapid, miniature and high-sensitivity sensors to control the environment is a topical problem of analytical chemistry is a topical issue of analytical chemistry. The purpose of this paper is to create an ion-selective electrode for determining the chromium (VI). The electrode was formed by sequential electrochemical assembly. Chromotropic acid was used to form a stable compound with chromate ions. In order to create a highly developed electroactive surface, a polyaniline film was previously formed on the electrode. The tetraethoxysilane film was used as a semi-permeable membrane to prevent the washing out of modifier. This work studied the mechanism of analytic signal formation and proposed a possible structure of the final complex. The electrode allows determining the chromium concentration in the range of 10–6 ÷10–1 M. The method “introduced-found” and measurement data obtained by the method of spectrophotometry validate the results.