bluuebunny/crossref_metadata_2025 huggingface dataset:
The Annual Report of the Institute of Archaeology (1937–58): history, development and access
Authors: Meheux Katie
Published: January 2023

The Annual Report of the Institute of Archaeology (1937–58) is now available as an open-access journal through a UCL digitisation initiative. This article aims to draw attention to the history of the Report and its potential for research into both the history of the Institute of Archaeology and the wider discipline. Research examines the Report within the context of the professionalisation of archaeology in the mid-twentieth century and explores how contemporary journals recorded, reflected and promoted contemporary changes, notably debates surrounding the role of ‘amateurs’ and post-war intellectual internationalism. Vere Gordon Childe’s creative control of the Annual Reports is used to investigate the complex entanglements between institutions and individuals and the roles played by archaeological literature in these interactions.
Minimal Search from Different Viewpoints
Authors:   The Society Of Modern Grammar, Kim Yong-Ha
Published: January 2023

In recent minimalist syntax, Minimal Search, MS plays the role of a bona fide 3rd factor principle, which is supposed to regulate most operations and algorithms in human language computation such as Merge, Agree, and labeling (Chomsky 2013, 2015, 2019a,b, 2021). A minimalist syntactician who seeks to explain syntactic phenomena in a particular language, hence, is doomed to revise his or her work that was based on old concepts about locality. In this paper, we will touch some concepts of locality, old or new, and try to find out potential problems that we can encounter when we pursue MS-based account of locality phenomena.
A Study on the Discourse Function of ‘Inja’: Focusing on Gwangju’s Daily Language
Authors:   The Society Of Modern Grammar, Mizukai Yukari , Kang Youngran , Cho Hajin , Xiao Shennian
Published: January 2023

This study aims to reveal what kind of discourse function the discourse marker ‘Inja’ frequently used in Gwangju’s daily language performs. Unlike previous studies on ‘Inja’, this study attempted to systematically analyze discourse functions from microscopic, macroscopic perspectives and even functions related to emotions. As for the analysis data, transcription data and video data obtained through interviews with merchants in the Gwangju market were targeted. As a result of analyzing this data, a total of 13 functions were identified as the discourse function of ‘Inja’, which appears frequently in Gwangju’s daily language. Macroscopic functions include ‘topic switching function’, ‘topic induction function’, ‘topic focus function’, ‘topic closing function’, ‘topic addition function’, and microscopic functions ‘time-earning function’, ‘information supplement function’, ‘utterance closing function’, ‘utterance access function’, ‘hesitation’, ‘pause function’, ‘citation sign function’, ‘filling blanks in information’ were used. Among these functions, this study newly presented ‘topic closing function’, ‘sentence closing function’, ‘hesitation’, ‘pause function’, ‘citation sign function’, and ‘filling blanks in information’ as functions that have not been mentioned in previous studies. As such, the realization of ‘Inja’ used in various possibilities was confirmed in the analysis data. Finally, as a result of network analysis to confirm the relationship between the use of ‘Ije’ and ‘Inje’, which show similar use of ‘Inja’, it was revealed that only ‘Inja’ has ‘citation sign function’ and ‘filling blanks in information’.
The Realization Pattern of Korean Final-Ending ‘-ji’
Authors:   The Society Of Modern Grammar, Lee So-Yul
Published: January 2023

The purpose of this study is to confirm the realization pattern of the intonation of the Korean final-ending ‘-ji’. In addition, we examine whether there are differences in the realization of intonation in Seoul/Gyeonggi-do and Daegu/Gyeongsangbuk-do depending on the sentence type. And the different utterances between the two regions are presented through the intonation type of the final ending ‘-ji’ appearing in the two regions and physical properties(utterance length, utterance start point, utterance end point, slope). The experiment of this study present objective data using a statistical program after extracting it by conducting production test on participants. An important point in this study is that it presents the difference in intonation between the two regions according to sentence type through objective data.
Bibliografia historii wychowania, szkolnictwa i myśli pedagogicznej w Polsce za rok 2019 (z uzupełnieniami za lata poprzednie)
Authors: Gruca Anna
Published: January 2023

Bibliografia historii wychowania, szkolnictwa i myśli pedagogicznej w Polsce za rok 2019 (z uzupełnieniami za lata poprzednie)
Edukacja międzykulturowa w edukacji wczesnoszkolnej: perspektywa historyczno-pedagogiczna i dobre praktyki nauczycieli na przykładzie Prywatnej Szkoły Podstawowej „Mieszko” w Poznaniu
Authors: Adamczewski Jakub , Płonka Joanna
Published: January 2023

The aim of this article is to present a historical perspective on intercultural education, contemporary methods of supporting foreign students as well as the role of the teacher and the specific competence required to teach effectively in an intercultural environment. Contemporary methods of support are presented based on the example of good educational practice taking place at “Mieszko” Private Elementary School in Poznań. Actions that can be initiated by a teacher in early education have been divided into four areas: physical, didactic, social and in the classroom. The physical area addresses the issue of school space and activities that help to identify and address students’ difficulties in areas related to senses and coordination. The didactic area represents cultural events designed to entertain and educate; there are also examples of how to equalize educational opportunities among students. The subsequent area, encompassing activities carried out within a class group, show intercultural activities included in the curriculum and indicate which activities may help to control difficult behaviours of children. The social area activities are designed to support students in maintaining meaningful relationships with their peers and collaborating with other organizations that can complement and enrich intercultural formal education.
Caracterização e avaliação da capacidade antioxidante do fruto mari-mari (Cassia leiandra Benth)
Authors: Da Silva dos Santos Elenna Rachel , Da Silva Santos Alessandra , Ferreira da Silva Viana Alciene , Silva de Oliveira Kelliane , Da Silva Abreu Alcicley , Da Silva Bruno Alexandre , Soares Barata Lauro Euclides , Rocha de Oliveira Johnatt Allan , Da Silva Martins Luiza Helena , Moreira Débora Kono Taketa
Published: January 2023

A Amazônia possui uma grande variedade de frutas exóticas e comercialmente subutilizadas com alto valor nutricional e alto teor de compostos bioativos que ainda são pouco exploradas na região amazônica. A Cassia leiandra Benth é uma espécie nativa da Amazônia que tem o fruto bastante consumido in natura, este fruto é conhecido popularmente como mari-mari, ingá-mari e marimarizeiro. O objetivo desse estudo foi avaliar as características biométricas do fruto de mari-mari, a sua composição centesimal e fitoquímica, bem como a avaliação da capacidade antioxidante de suas diferentes partes. O fruto pode ser descrito como comprido, fino e com baixo rendimento de polpa, tendo como o seu maior constituinte a semente. A polpa apresentou maior conteúdo de umidade, a semente de proteínas e a casca de cinzas e carboidratos. A casca apresentou o maior teor de fenólicos e a amêndoa o maior teor de flavonoides. A casca apresentou maior capacidade antioxidante frente aos métodos do DPPH, ABTS e FRAP. O fruto mari-mari se apresentou neste estudo como uma matéria-prima promissora para o desenvolvimento de produtos nutracêuticos e alimentícios.
Role and the importance of green approach in biosynthesis of nanopropolis and effectiveness of propolis in the treatment of COVID-19 pandemic
Authors: Barsola Bindiya , Saklani Shivani , Kumari Priyanka , Sidhu Avtar K. , Dhar Anjoo
Published: January 2023

The most fascinating product of honeybee is propolis. It has an immense role in dentistry, dermatology, and otorhinolaryngology. The increased popularity of propolis as an important remedy is due to its constituents, which have anti-inflammatory, immunomodulatory, antihepatotoxic, anti-cancerous, antifungal, antioxidant, antidiabetic, and antiviral activities. The diverse biological and pharmacological activities of propolis have piqued the interest of many scientists. Many techniques like gas chromatography-mass spectrometry, chromatography, and spectroscopy are being used to identify different propolis constituents. Flavonoids, phenolic acids, and their esters are the most pharmacologically active molecules of propolis and are known to disrupt the replication machinery of the virus corroborating the anti-coronavirus activity of propolis. The main aim of this article is to provide an insight of the increasing theragnostic uses of propolis and its nanoparticles, including their chemical analysis, diverse biological activities, and the necessity for chemical standardization. In this review, we have focused at the promising effects of propolis, its optimization, and its liposomal formulation as a therapeutic intervention for COVID-19 and its accompanying comorbidities.
Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment
Authors: Li Hanmei , Gou Rui , Liao Jiaying , Wang Yao , Qu Rui , Tang Qi , Gan Jingyao , Zou Liang , Shi Sanjun
Published: January 2023

Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage destruction and periarticular bone erosion, thus ultimately compromising joint integrity and function. Anti-inflammatory drugs and biological agents are commonly used to treat rheumatoid arthritis, but they cannot selectively target inflamed joints, because of their systemic mechanisms, short half-lives and low bioavailability. Consequently, these agents must be used at high doses and delivered frequently, thereby increasing costs and the risk of adverse effects. Drug delivery systems, such as nanoparticles, liposomes and micelles, can significantly prolong drug half-life in the body and enable targeted delivery into the joints. In this review, we comprehensively describe the pathogenesis and clinical diagnosis of rheumatoid arthritis, and summarize recent advances in targeted therapeutic strategies, particularly nano-targeting systems for rheumatoid arthritis.
α-Synuclein Promotes Neuronal Dysfunction and Death by Disrupting the Binding of Ankyrin to β-Spectrin
Authors: Maor Gali , Dubreuil Ronald R. , Feany Mel B.
Published: January 2023

α-Synuclein plays a key role in the pathogenesis of Parkinson’s disease and related disorders, but critical interacting partners and molecular mechanisms mediating neurotoxicity are incompletely understood. We show that α-synuclein binds directly to β-spectrin. Using males and females in aDrosophilamodel of α-synuclein-related disorders, we demonstrate that β-spectrin is critical for α-synuclein neurotoxicity. Further, the ankyrin binding domain of β-spectrin is required for α-synuclein binding and neurotoxicity. A key plasma membrane target of ankyrin, Na+/K+ATPase, is mislocalized when human α-synuclein is expressed inDrosophila. Accordingly, membrane potential is depolarized in α-synuclein transgenic fly brains. We examine the same pathway in human neurons and find that Parkinson’s disease patient-derived neurons with a triplication of the α-synuclein locus show disruption of the spectrin cytoskeleton, mislocalization of ankyrin and Na+/K+ATPase, and membrane potential depolarization. Our findings define a specific molecular mechanism by which elevated levels of α-synuclein in Parkinson’s disease and related α-synucleinopathies lead to neuronal dysfunction and death.

SIGNIFICANCE STATEMENTThe small synaptic vesicle associate protein α-synuclein plays a critical role in the pathogenesis of Parkinson’s disease and related disorders, but the disease-relevant binding partners of α-synuclein and proximate pathways critical for neurotoxicity require further definition. We show that α-synuclein binds directly to β-spectrin, a key cytoskeletal protein required for localization of plasma membrane proteins and maintenance of neuronal viability. Binding of α-synuclein to β-spectrin alters the organization of the spectrin-ankyrin complex, which is critical for localization and function of integral membrane proteins, including Na+/K+ATPase. These finding outline a previously undescribed mechanism of α-synuclein neurotoxicity and thus suggest potential new therapeutic approaches in Parkinson’s disease and related disorders.
Brain State-Dependent Modulation of Thalamic Visual Processing by Cortico-Thalamic Feedback
Authors: Reinhold Kimberly , Resulaj Arbora , Scanziani Massimo
Published: January 2023

The behavioral state of a mammal impacts how the brain responds to visual stimuli as early as in the dorsolateral geniculate nucleus of the thalamus (dLGN), the primary relay of visual information to the cortex. A clear example of this is the markedly stronger response of dLGN neurons to higher temporal frequencies of the visual stimulus in alert as compared with quiescent animals. The dLGN receives strong feedback from the visual cortex, yet whether this feedback contributes to these state-dependent responses to visual stimuli is poorly understood. Here, we show that in male and female mice, silencing cortico-thalamic feedback profoundly reduces state-dependent differences in the response of dLGN neurons to visual stimuli. This holds true for dLGN responses to both temporal and spatial features of the visual stimulus. These results reveal that the state-dependent shift of the response to visual stimuli in an early stage of visual processing depends on cortico-thalamic feedback.

SIGNIFICANCE STATEMENTBrain state affects even the earliest stages of sensory processing. A clear example of this phenomenon is the change in thalamic responses to visual stimuli depending on whether the animal’s brain is in an alert or quiescent state. Despite the radical impact that brain state has on sensory processing, the underlying circuits are still poorly understood. Here, we show that both the temporal and spatial response properties of thalamic neurons to visual stimuli depend on the state of the animal and, crucially, that this state-dependent shift relies on the feedback projection from visual cortex to thalamus.
ULTRASONİK DESTEKLİ EKSTRAKSİYON YÖNTEMİ İLE ELDE EDİLEN ZEYTİN YAPRAĞI EKSTRAKTININ İYONİK JELASYON YÖNTEMİ İLE ENKAPSÜLASYONU VE KEFİR İÇECEĞİNDE KULLANILMASI
Authors: AKÇAY SALIK Rabia , BİTİM Ezgi , KÖPRÜALAN Özgün , SELÇUK Esin , ALTAY Özgül , ERTEKİN Figen
Published: January 2023

Bu çalışmada zeytin yaprağından fenolik bileşenler ultrasonik destekli yöntem ile ekstrakte edilerek çözgen tipi (etanol ve etil asetat); katı/çözgen oranı (1:10, 1:15 ve 1:20 (a/h)); çözgen:su konsantrasyonu (90:10 (h/h), 80:20 (h/h), 70:30 (h/h)) belirlenmiştir. En yüksek ekstraksiyon verimi, toplam fenolik madde ve antioksidan kapasite değerleri; 1:20 (a/h) katı/çözgen oranı ve %90:10 (h/h) etanol-su karışımı koşullarında belirlenmiştir. Ultrasonik destekli ekstraksiyon yönteminde; sıcaklık, süre ve ultrasonik genliğin ekstraksiyon verimi, Box Behnken deney tasarımı kullanılarak, toplam fenolik madde ve antioksidan kapasite üzerine etkisi incelenerek, optimum süre 5.31 dak, sıcaklık 39.27ºC ve genlik %40.51 olarak belirlenmiştir. Daha sonra ekstraktlar iyonik jelasyon yöntemiyle enkapsüle edilmiş, ekstrakt konsantrasyonu, kitosan konsantrasyonu ve bekleme süresi CCRD deney tasarımı kullanılarak enkapsülasyon etkinliği ve toplam fenolik madde üzerine etkisi optimize edilmiştir. Enkapsülasyon işleminde optimum ekstrakt konsantrasyonu %1.04, kitosan konsantrasyonu %0.5 ve bekleme süresi ise 11.24 dak olarak saptanmıştır. Enkapsülasyon işleminin ekstraktın acı tat ve aromasını baskıladığı ve fonksiyonel gıda amacıyla üretilen kefir içerisine eklenen kapsüllerin laktik asit bakterilerini (LAB) inhibe edici etkisinin olmadığı saptanmıştır.
Menilik Kelayakan Substansi dan Bahasa Buku Ajar Jaminan Sosial Ketenagakerjaan pada Mahasiswa S1 Ilmu Hukum Universitas Negeri Surabaya
Authors: Nugroho Arinto , Rusdiana Emmilia
Published: January 2023

Buku ajar Jaminan Sosial Ketenagakerjaan tidak tersedia di Prodi S1 Ilmu Hukum, sementara dinamika jaminan sosial utamanya terkait dengan ketenagakerjaan sangat tinggi. Jenis pekerjaan yang beragam dan diantaranya sangat beresiko terjadi kecelakaan kerja, jadi keberadaan buku ajar Jaminan Sosial Ketenagakerjaan menjadi keharusan untuk disediakan.  Buku ajar ini dapat digunakan sebagai sumber belajar bagi mahasiswa untuk belajar secara mandiri karena memberi kemudahan bagi mahasiswa dalam mempelajari setiap kompetensi yang harus dikuasainya, sekaligus sebagai wahana pengembangan materi Jaminan Sosial Ketenagakerjaan sesuai dengan tuntutan kurikulum dan kebutuhan belajar mahasiswa.   Tujuan Penelitian ini adalah untuk mengetahui kelayakan materi buku ajar, kepraktisan serta  keefektifan dari sisi bahasa buku ajar Jaminan Sosial Ketenagakerjaan, penelitian menggunakan pendekatan Analyze, Design, Develop, Implement, and Evaluate (ADDIE). Pengumpulan  data dengan angket tertutup yang hasilnya diolah dalam bentuk penskoran dan diskusi dengan para ahli. Data yang diperoleh dari instrumen evaluasi dianalisis secara deskriptif kualitatif, dan menjadi bahan untuk memperbaiki  buku ajar. Hasil dan pembahasan menunjukkan bahwa hasil berupa buku ajar masih memerlukan beberapa perbaikan dalam ketiga aspek kelayakan tersebut yakni kelayakan isi, dan kelayakan bahasa serta penyajian. Saran yang diajukan adalah urgensi penyelenggaraan pelatihan dan pendampingan dalam penyusunan buku ajar bagi perguruan tinggi.
Penguatan budaya sekolah dalam pemahaman hak konstitusional melalui tim konstitusi
Authors: Aulia Syifa Siti , Supriyanti Supriyanti
Published: January 2023

Abstrak___________________________________________________________________Tujuan penelitian ini adalah dapat mengetahui atau mendeskripsikan sejauh mana peranan tim konstitusi dalam pemahaman hak konstitusional melalui budaya sekolah yang ada di SMA Negeri 5 Yogyakarta. Penelitian ini menggunakan jenis penelitian deskriptif kualitatif dengan prosedur penelitian yang menggunakan kata-kata tertulis atau lisan orang-orang dan perilaku yang diamati. Lokasi penelitian yaitu SMA Negeri 5 Yogyakarta dengan subjek penelitian yaitu Pembina Tim Konstitusi, anggota Tim Konstitusi dan siswa. Objek penelitian ini adalah kegiatan-kegiatan yang di lakukan di dalam ke anggotaan Tim Konstitusi. Hasil penelitian ini menunjukan bahwa melalui budaya yang di terapkan d dalam Tim Konstitusi menjadikan siswa anggota Tim Konstitusi memiiliki pemahaman mengenai hak konstitusional sebagai warga negara. Dengan adanya pemahaman akan hak-hak konstitusional menjadikan anggota Tim Konstitusi mampu berpikir kritis, logis dan mampu menyampaikan pendapat di depan umum karena mereka terlatih untuk hal itu, sehingga hal tersebut secara tidak langsung menjadi teladan ataupun conoth bagi siswa maupun warga sekolah.
Celebrity Worship Ditinjau Dari Tipe Kepribadian Introvert dan Ekstrovert Pada Penggemar K-Pop
Authors: Hariyadi Sugeng , Kemalasari Melania Laillita
Published: January 2023

Penelitian ini bertujuan untuk menguji ada tidaknya perbedaan perilaku celebrity worship ditinjau dari tipe kepribadian introvert dan ekstrovert pada penggemar K-Pop, mengetahui gambaran perilaku celebrity worship pada penggemar K-Pop ditinjau dari tipe kepribadian introvert, mengentahui gambaran perilaku celebrity worship pada penggemar K-Pop ditinjau dari tipe kepribadian ekstrovert. Penelitian ini merupakan penelitian kuantitatif komparasi, populasi dalam penelitian ini adalah penggemar K-Pop di Provinsi DKI Jakarta. Sampel penelitian berjumlah 131 orang dengan menggunakan teknik sampling quota sampling. Pengumpulan data dilakukan dengan menggunakan skala Celebrity Attitude Scale yang telah dimodifikasi yang berisi 25 item valid untuk pengukuran tingkat celebrity worship dan menggunakan skala Eysenck Personality Inventory yang telah dimodifikasi untuk pengukuran tipe kepribadian introvert dan ekstrovert. Validitas penelitian ini menggunakan teknik Korelasi Pearson dan reliabilitas penelitian ini ditemukan koefisien reliabilitas sebesar 0,829. Teknik analissi data yang digunakan pada penelitian ini adalah Wilcoxon Mann-Whitney U Test. Hasil uji hipotesis menunjukan nilai signifikansi sebesar Sign 0,008. Oleh karena Sign < α 0,05 maka hipotesis yag berbunyi “Ada Perbedaan pada Perilaku Celebrity Worship ditinjau dari Tipe Kepribadian Introvert dengan Tipe Kepribadian Ekstrovert pada Penggemar K-Pop” diterima.
Proximate analysis of bamboo culm and wood carbonized at low temperatures: A comparative study
Authors: Yang Go Un , Purusatama Byantara Darsan , Kim Jong Ho , Prasetia Denni , Savero Alvin Muhammad , Kim Nam Hun
Published: January 2023

To obtain basic data for further use of bamboo culms and wood as eco-friendly bioenergy resources, the proximate analysis of Dendrocalamus giganteus, D. asper, Bambusa vulgaris, Gigantochloa apus, Phyllostachys pubescens, Pinus densiflora, and Quercus variabilis carbonized at 200 to 320 °C at 40 °C intervals was undertaken. Proximate analysis of moisture content, ash content, volatile matter, and fixed carbon content was performed according to JIS M 8812 (2004) with 60-mesh carbonized powder. Carbonized bamboo showed higher ash and volatile content than carbonized wood, whereas carbonized wood had a higher fixed carbon content than carbonized bamboo. At all temperatures, giant bamboo had the highest ash content. In bamboo and wood, the ash and fixed carbon contents increased with increasing carbonization temperature, whereas the volatile substances decreased.
Motives for Assuming and Continuing Family Care: Family Caregivers’ Perspective
Authors: Charenkova Jūratė
Published: January 2023

Studies have shown that the circumstances and motivation for becoming a caregiver are closely related to the caregiver’s well-being and the quality of care provided, which, in turn, affects the quality of life of the person receiving the care. This article aimed to reveal the motives behind decisions related to an aging relative’s care – motives to assume the caregiving duties and motives to remain in the caregiving role. In total, seven family caregivers participated in semi-structured interviews. Two main themes related to caregiving motivation were revealed: (1) motives to assume the caregiver role, and (2) motives to continue with family care. The results of the research were interpreted using the perspective of self-determination theory (Ryan & Deci, 2000; 2017). This study revealed that key motivational drivers of caregiving decisions were associated with the satisfaction of the three basic psychological needs – autonomy, competence, and relatedness. Meeting these needs in the context of caregiving not only strengthened the caregivers’ motivation to take on the caregiving role but also motivated them to continue with family care, even after the autonomy of care recipients had increased significantly.
Chemo-mechanical properties of the new bioceramic cement PBS CIMMO® compared to MTA REPAIR HP Angelus® cement
Authors: Gonçalves Lísia AC , Moreira Geovane E , Casque Kellen CS , Frozoni Marcos RS , Amaral Flávia LB
Published: January 2023

Objective: To evaluate the bond strength (BS), pH and solubility (Sol) of a new PBS HP® bioceramic cement compared to MTA REPAIR HP® cement. Material and methods: Twenty human premolars were selected for BS analysis. Roots were cut into thirds (cervical, medium and apical) and filled with one of the cements (n=10): PC (PBS HP) or MC (MTA REPAIR HP). Half of these samples were subjected to 2,000 thermal cycles. After 48 hours, the BS test was performed in a universal testing machine (0.5mm/min). Cylindrical specimens (1.0mm in diameter and 10mm in height) were made with PC or MC and immersed in distilled water for pH analysis. After 0.3 and 24 hours, the pH was measured. Solubility was evaluated through the mass loss of the samples after 24 hours. Teflon rings of 20mm in diameter and 1.5mm in height were filled with PC or MC and kept at 37ºC in 100% humidity. Descriptive and exploratory analyzes of BS, pH and Sol data were performed (p<0.05). Results: There was no significant difference in BS between the two types of cement. Thermo cycling did not affect the BS (p>0.05). MC cement showed significantly higher pH values than the PC at the initial and 3 hours (p<0.05). There was no difference between them (p>0.05) after 24 hours. There was no significant difference regarding solubility (p>0.05). Conclusion: Bioceramic cements have similar properties, as they did not differ in relation to dentin bond strength, pH after 24 hours and solubility.
Suggestion of a fimH Inhibitor by a Molecular Docking Method for Escherichia coli Isolated from Clinical Samples of Patients with UTI
Authors:   Medical college at the University of Babylon, Alnuaimi A.A.R. , Alsaeid M.S. ,   Medical college at the University of Babylon, Abolmaali H.M. ,   College of Pharmacy at the University of Karbala
Published: January 2023

E. coli is one of the most important organisms that cause urinary tract infection (UTI) in more than 95% of patients with UTI. The aim of this study was to search for inhibitors of (fimH) by a docking method using computer programs and websites specialized for this purpose. Methods. This study involved 63 samples with positive E. coli collected from patients with UTI from February 2021 to October 2021 at the Iraqi hospital in Karbala. Full laboratory investigation for E. coli was made to detect FimH and predictsuitable inhibitors. The Fast Identification System VITEK-2, compact DNA extraction system, and PCR Molecular docking were used. Studies of FimH inhibitor for animals were performed as well. Results. FimH was found in most E. coli isolates, namely in 61 (96.82%) of 63 samples. The principle of the experiment is dependent on activated infection on animals with/without feeding with our drug (chamomile), and then the counted E. coli in their urine chamomile appears to be a good FimH inhibitor, with a docking score of -9.4, and to be able to reduce UTI in roughly 50 percent of rats examined. Conclusions. The chamomile was predicted as a suitable inhibitor of (fi mH) and then tested on rats. The results showed its good inhibitory properties.
Population density of the wild boar (Sus scrofa) in south-western Poland in 1981–2020
Authors:   Wrocław University of Environmental and Life Sciences (Wrocław, Poland), Kopij Grzegorz
Published: January 2023

The study is based on the analysis of hunting bag data from the years 1981–2020. In 1980–1990, 38 016 wild boars, whereas in 1991–2000, 43 490 wild boars were culled (14.4% increase) in south-western Poland (29 358 km2, forests comprise 28.6%). In 2001–2010, there were 69 052 individuals harvested (58.8% increase in relation to the previous decade). In 2011–2020, the harvest was 3-fold higher in relation to the previous decade and 5.6-fold higher in relation to 1980–1990. During the years 1981–1990, an estimated number of 51–100 wild boars were recorded only in five hunting districts, whereas there were 23 such districts in the next decade. After a population expansion in 2001–2010, there were 32 districts, each one with 101–200 wild boars. Ecological population densities (per forest area) of the wild boar was spatially greatly varied in south-western Poland, ranging from 9.1 ind./1000 ha in extensive woodlands of the Lower Silesian Forests to as much as 147.2 ind./1000 ha in the Wrocław Plain dominated by farmlands with forest fragments. The crude density was much lower and much less spatially varied than the ecological density; it was the lowest (7.4 ind./1000 ha) in the West Sudeten Mts. and the highest, 23.8 ind./1000 ha in the East Sudeten Mts. When only ecological density is calculated, a strongly distorted picture may emerge, where the highest density will always be in deforested areas with forest fragments, whereas it will be inevitably the lowest in the most afforested ones. The crude density will, therefore, reflect much better the actual population densities. In comparison with the line transect track index, the hunting bags analysis provide similar population density estimates, whereas in the comparison with the block count census, population densities based on the hunting bag analysis are underestimated. However, it should be emphasised that density estimates based on hunting bag analysis will always be lower than the real densities, as not all animals are harvested in a given population. The following ecological variables may shape wild boar population density in south-western Poland: food resources (maize, mast); temperature (winter and early spring); precipitation (snow and rainfalls); and diseases (especially African swine fever).
Propranolol Therapy for Congenital Chylothorax
Authors: Handal-Orefice Roxane , Midura Devin , Wu June K. , Parravicini Elvira , Miller Russell S. , Shawber Carrie J.
Published: January 2023

Congenital chylothorax is a rare and often severe anomaly without well-established medical therapies. Previously, propranolol use in patients with lymphatic malformations and secondary chylothorax was associated with improvement in clinical signs. We hypothesized that propranolol treatment would be beneficial for severe congenital chylothorax. We reviewed medical records of neonates born from 2015 to 2019 at our tertiary center with a prenatal diagnosis of congenital chylothorax for whom either prenatal or postnatal propranolol therapy was initiated. Inclusion was limited to fetuses diagnosed with severe congenital chylothorax without significant genetic, infectious, or cardiac anomalies, and who underwent prenatal interventions to mitigate consequences of the condition. Propranolol was administered orally to pregnant women at 20 mg 4 times daily and increased to a maximum dose of 40 mg 4 times daily, or to infants at 0.3 mg/kg/d and increased to 1 to 2 mg/kg/d. Primary outcomes were the time course of resolution of ultrasonographical, clinical, and/or radiologic signs of chylothorax after treatment with propranolol. Four neonates met the inclusion criteria. In 2 cases, prenatal initiation of propranolol led to resolution of the chylothoraxes before delivery (38 and 32 days after treatment) on a dose of 40 mg/day 4 times daily. Neonates had a normal postnatal course. Postnatal propranolol was initiated in 2 neonates with respiratory failure when chylothoraces were refractory to standard management. Stabilization and improvement of their pleural effusion was observed by imaging at 29 and 13 days after initiation of propranolol. There were no significant maternal or neonatal complications from prenatal or postnatal propranolol use. Propranolol may be efficacious in treating severe fetal congenital chylothorax.
Stefan Pohl-Valero y Joel Vargas Domínguez, eds. El hambre de los otros. Ciencia y políticas alimentarias en Latinoamérica, siglos XX y XXI.
Authors: Hernández Quiñones Óscar Daniel
Published: January 2023

Este libro recoge doce ponencias presentadas por un nutrido grupo interdisciplinar en el año 2019 para el encuentro académico internacional “Ensamblajes del problema alimentario en América Latina durante el siglo XX” (Bogotá). A su vez, se encuentra inscrito en el desarrollo de proyectos más amplios que sus editores, Stefan Pohl y Joel Vargas, vienen adelantando en Colombia y México, respectivamente. Quizás el que más merezca la pena destacar por tratarse de un punto de convergencia, es la consolidación de la Red de Estudios Históricos y Sociales de la Nutrición y Alimentación en América Latina (REDEHSNAL); un esfuerzo colaborativo creado para dar visibilidad a los avances de dicho campo a través de formatos variados que van desde coloquios y novedades bibliográficas en redes sociales, hasta espacios de corte más divulgativo como el podcast Alimentando la Historia. Ciertamente, estos antecedentes hablan muy bien del Hambre de los otros, toda vez que no se presenta al lector como la publicación espontánea de un colectivo aislado, sino como el producto de una activa comunidad que incluye jóvenes investigadores, y cuya disposición para transitar entre distintas formas comunicativas es síntoma de la buena salud de su agenda.
Exhibir para no mostrar: Colombia en la Guerra de Corea (1951-1954) en el Museo Militar de Colombia y en el Museo Naval del Caribe
Authors: León Cabrera Gina Catherine
Published: January 2023

Objetivo: el artículo compara las prácticas de memoria sobre la participación colombiana en la Guerra de Corea (1951-1954) en las exhibiciones Sala Corea del Museo Militar de Colombia y Galería Naval del Museo Naval del Caribe. El trabajo evidencia cómo se construyen estas narrativas en el Ejército y la Armada colombianas y cómo estas representaciones del pasado revelan marcos de interpretación sobre el conflicto interno por parte de algunos sectores de las Fuerzas Militares. Metodología: desde los estudios sociales de la memoria, los museum studies y los estudios del discurso, se realiza una etnografía de los procesos discursivos en las dos exposiciones a partir del concepto “políticas de exhibición”. Originalidad: la construcción de memorias en los museos militares es un tema poco explorado en la investigación académica en Colombia siendo este sector un actor que ingresa con fuerza en las disputas de la memoria histórica en el país. En particular, el rol de Colombia en la Guerra de Corea ha sido poco abordado dentro de la historiografía nacional, dejando de lado la pregunta por el papel que cumple como hito contrainsurgente en las instituciones castrenses. Conclusiones: el artículo identifica cómo en los museos analizados se utiliza una estrategia discursiva de ocultamiento que caracteriza un tipo de prácticas memoriales desde el sector militar, su papel en el adoctrinamiento nacionalista en la década de los años ochenta y sugiere debates sobre las herencias de esta forma de construcción del pasado en las nuevas disputas por la memoria histórica en el país.
In memoriam: as reparações simbólicas demandadas pela Corte Interamericana de Direitos Humanos e o impacto das instituições internacionais na memória coletiva
Authors: Machado Haertel Letícia
Published: January 2023

Objetivo: este artigo analisa o potencial impacto que instituições internacionais podem exercer sobre as dinâmicas de memória coletiva dentro dos Estados a partir do estudo de caso das medidas de reparação ordenadas pela Corte Interamericana de Direitos Humanos no caso “Prisão Miguel Castro Castro vs. Peru” em 2006, que demandou a modificação do monumento “Ojo que Llora”, localizado em Lima. Metodologia: após uma descrição do contexto que levou a Corte a ordenar a modificação do “Ojo que Llora”, concebido para rememorar as vítimas do conflito armado ocorrido no Peru entre 1980 e 2000, as consequências do julgamento são analisadas à luz de conceitos como memória coletiva, memória oficial, disputas de memória, memórias subterrâneas e lugares de memória. A escolha da Corte Interamericana como objeto de análise se baseia na sua capacidade única, dentre as cortes regionais de direitos humanos, de determinar uma diversidade de medidas simbólicas como reparações por violações de direitos humanos, incluindo a construção e modificação de lugares de memória. Originalidade: embora o poder de influência de um Estado na memória coletiva dos grupos sociais é amplamente reconhecido e investigado no campo dos estudos de memória, esta pesquisa inova ao propor considerações sobre o papel de instituições supranacionais neste processo. Conclusões: o estudo da repercussão do julgamento permite observar a influência que instituições internacionais podem exercer na memória coletiva dentro dos Estados. Nesse sentido, a prática da Corte Interamericana de mobilizar lugares de memória em homenagem às vítimas de violações de direitos humanos como medida de reparação, apesar de positiva, demanda grande cautela.
Manuel Gámez Casado. Ingeniería militar en el Nuevo Reino de Granada. Defensa, poder y sociedad en el Caribe sur (1739-1811).
Authors: Moreno Cabanillas Rocío
Published: January 2023

Manuel Gámez Casado nos introduce en este libro en el entorno de la arquitectura militar de la costa caribeña de la Nueva Granada, especialmente el Caribe panameño, el santafereño y el venezolano, que conformaron un telón defensivo esencial de la Corona borbónica en el espacio caribeño, debido a las experiencias y trayectorias de sus ingenieros. En este escenario de competencia se desencadenaron numerosos conflictos globales entre los distintos imperios durante los siglos XVIII y XIX. Este libro se sitúa en el marco cronológico que va desde 1739, con la disputa conocida como la Guerra del Asiento —que impulsó la reformulación de los sistemas defensivos—, hasta 1811, cuando sucedieron los primeros movimientos insurgentes en Hispanoamérica, momentos en los que las defensas de las ciudades fueron protagonistas de las disputas bélicas.
Mabel Paola López Jerez, editora académica. Ni calladas ni sumisas. Trasgresión femenina en Colombia, siglos XVII-XX.
Authors: Torres Cendales Leidy Jazmín
Published: January 2023

Sin duda, el texto editado por Mabel López constituye un aporte historiográfico por muchos motivos. Por una parte, traspasa la frontera entre investigación y divulgación, pues sus temas son llamativos y su estilo de escritura es comprensible para públicos no expertos. Este es el sello de su editora, doctora en Historia con formación en Comunicación Social y Edición de libros, y quien ha realizado con éxito ambas labores en sus publicaciones y su canal de YouTube. De igual manera, el libro rompe con las divisiones entre grados académicos y disciplinas, en tanto fue escrito por investigadoras con pregrados, maestrías o doctorados en Historia y otras áreas como los Estudios de Género o la Sociología, y supera los prejuicios de género en el gremio, pues dos de los autores dejaron de lado la idea de que la historia de las mujeres solo puede ser escrita por nosotras.
Exploring the use of raw honey as a fuel source for microbial fuel cells
Authors: Kpeli Matilda , Donkor Michael K. E. , Tamakloe Reuben
Published: January 2023

Microbial fuel cell (MFC) technologies are making headway in developing and expanding renewable energy through the conversion of organic matter to electricity. Various substrates can be used in the MFCs technology to enable energy generation, either pure substances or complex mixtures of organic materials. This study aims to consider the feasibility of raw honey as a fuel for mediator-less double-chamber MFC. The cell voltage was monitored in mediator-less double-chamber H2O2 cathode  microbial fuel cell. The Mfensi clay partition and the raw honey were analyzed using FTIR-ATR. The results show the highest open-circuit voltage of 1414 mV with a maximum current density of 0.6540 A/m2 and a maximum power density of 247.0 W/m2. These results demonstrate that raw honey can be used for power generation in MFCs and for practical applications.
The influence of the vine rootstock on the agrobiological and technological characteristics of the Kaylashki Rubin variety
Authors: Yoncheva T. , Iliev A. , Emurlova F.
Published: January 2023

The rootstock had a significant impact on the quantity and quality of grapes of the varieties grafted on it. That had been determined by the different growth strength of the rootstocks, their different absorption capacity and compatibility with the cultivated vine. During the period 2017-2020, a study was carried out on the agrobiological and technological properties of grapes and wine of the Kaylashki Rubin variety, grafted on vine rootstocks SО4, 110 Rihter, 44-53 Malegue and Fercal. Differences in the investigated indicators were found as a result of the influence of the used rootstocks. A mechanical analysis was made to determine the composition and structure of the clusters and berries. For the period, the highest average yield per vine was reported for Fercal rootstock, while the best theoretical yield had the variant on 44-53 Malegue rootstock. The chemical composition of grapes and experimental wines had been determined. On the average for the period the highest sugar accumulation and respectively the lowest titratable acids in grapes were reported in the variant of 44-53 Malegue rootstock. The opposite relationship was observed for 110 Richter. Differences in the chemical composition of the wines depending on the used rootstocks were found. The wines from 44-53 Malegue variant had the highest average alcohol content and sugar-free extract, but the lowest rates of titratable acids. The average amounts of the total phenolic compounds and anthocyanins in the wines from the variants of the different rootstocks were close. Their values were the lowest in the samples 2017 vintage. The rootstock type also affected the organoleptic properties of the Kaylashki Rubin wines; however, there was no common trend for the studied period. In 2018 and 2020, the samples from the 110 Rihter variant showed the best tasting qualities.
Group format psychedelic-assisted therapy interventions: Observations and impressions from the HOPE trial
Authors: Lewis Benjamin R. , Byrne Kevin , Hendrick John , Garland Eric L. , Thielking Paul , Beck Anna
Published: January 2023

Background

Psilocybin-assisted psychotherapy has demonstrated significant promise as a treatment for depression, anxiety, and existential distress associated with serious medical illness and has generally been employed on an individual basis, which presents challenges for scaling and resource availability. There are also compelling theoretical reasons to suggest that group-based formats-if utilized in a thoughtful fashion-might offer unique or enhanced therapeutic benefits for certain conditions or populations. The HOPE trial is an IRB-approved open-label feasibility and safety pilot study of psilocybin enhanced group therapy in patients with a DSM-5 depressive disorder associated with a cancer diagnosis completed at the Huntsman Cancer Institute (HCI) in Salt Lake City, Utah (HOPE: A Pilot Study of Psilocybin Enhanced Group Psychotherapy in Patients with Cancer). We report here qualitative survey-based data, impressions, and suggestions for group-based psychedelic-assisted therapy interventions based on our observations to inform future studies.

Methods

Patients with a DSM-5 depressive disorder with an underlying cancer diagnosis were recruited from HCI by referral from oncology providers, palliative care, and social work. Following screening and consenting, 4-6 participants per cohort (with three total cohorts) were enrolled in a protocol involving 3 120 min group preparatory sessions, a single high-dose (25 mg) group psilocybin session, and 3 subsequent group integration sessions. Primary clinical outcomes are still in process of data collection and analysis. Qualitative data was gathered from patient written reports and a survey administered at 2 weeks post intervention. Qualitative reports were also gathered from the therapist team at a post-study group process session.

Findings

We report here results from a qualitative survey of participant experiences with group format study design, as well as impressions and guidelines for group format and group psychotherapeutic process to inform other studies pursuing group-based interventions in psychedelic therapy. Suggestions are provided for protocol design, screening processes, space considerations, therapist team structure, group process, music, timeline, as well as potential issues and challenges.
Radionuclide distribution in irradiated BWR tie plate
Authors: Sakuragi Tomofumi , Nakai Yuki , Yamamoto Shuji , Kume Naoto , Sugita Tsukasa , Yamashita Yu , Ueda Hiroyoshi
Published: January 2023

The contents and distribution of radionuclides in activated metallic wastes are major concerns while designing a leaching model in a safety case. This study investigated 60Co as a typical activation product in the lower tie plate (i.e., stainless steel endpiece of BWR fuel assembly) irradiated for 35.0 GWd/tHM burnup, using the imaging plate (IP) method. The activation calculations coupled with the Monte Carlo burnup and neutron transport calculation code (MCNP-BURN2) were also performed based on the burnup and operation conditions. The Co impurity content in the irradiated tie plate was obtained and used as an input to MCNP-BURN2. The IP method results showed that the intensity of photostimulated luminescence decreased with increasing distance from the top (near fuels) to bottom. This trend was consistent with that exhibited by MCNP-BURN2.Therefore, the simulations allowed us to model the three-dimensional radionuclide distribution within the tie plate.

Graphical abstract

Distribution of 60Co in the irradiated lower tie plate. Left shows the vertical distribution comparing the measurements and the MCNP-BURN2 results. Right represents the 3D model of 60Co distribution in the lower tie plate.
Una obra de rehabilitación. La residencia asilo de Lerín
Authors: Urmeneta Tomás
Published: January 2023

Desde el caso propuesto como muestra de la realización de una obra de rehabilitación, se muestran los sistemas y secretos para llevar a buen término el complejo proceso de actualizar funcionalmente un edificio. La dificultad de la dirección de obra y las ventajas de la experiencia profesional frente a la consolidación de la estructura y redistribución del conjunto.
Der doktrinale Glaube und der Glaube aus der Begegnung
Authors: Dzidek Tadeusz
Published: January 2023

The paper’s title suggests that there is a tension any believer is destined to experience. Namely, every human being lives in the space spanned by his/her own experience of God, which can be called ‘a personal encounter’, and by the doctrine, that is, the structured content of religious beliefs suggested by his/her religious community. The question this paper addresses is the following: what are the constellations in which the faith of a personal encounter and the faith expressed in the doctrine can go together?