bluuebunny/crossref_metadata_2025 huggingface dataset:
A Fusion Encoder with Multi-Task Guided for Cross-Modal Text-Image Retrieval in Remote Sensing
Authors: Zhang Xiong , Li Weipeng , Wang Xu , Wang Luyao , Zheng Fuzhong , Wang Long , Zhang Haisu
Published: June 2023

In recent years, there has been a growing interest in remote sensing image-text cross-modal retrieval due to the rapid development of space information technology and the significant increase in remote sensing image data volume. One approach that has shown promising results in cross-modal retrieval of natural images is the multimodal fusion encoding method. However, remote sensing images have unique characteristics that make the retrieval task challenging. Firstly, the semantic features of remote sensing images are fine-grained, meaning they can be divided into multiple basic units of semantic expression. Additionally, these images exhibit variations in resolution, color, and perspective. Different combinations of basic units of semantic expression can generate diverse text descriptions. These characteristics pose considerable challenges for cross-modal retrieval. To address these challenges, this paper proposes a multi-task guided fusion encoder (MTGFE) based on the multimodal fusion encoding method. The model incorporates three tasks: image-text matching (ITM), masked language modeling (MLM), and the newly introduced multi-view joint representations contrast (MVJRC) task. By jointly training the model with these tasks, we aim to enhance its capability to capture fine-grained correlations between remote sensing images and texts. Specifically, the MVJRC task is designed to improve the model’s consistency in feature expression and fine-grained correlation, particularly for remote sensing images with significant differences in resolution, color, and angle. Furthermore, to address the computational complexity associated with large-scale fusion models and improve retrieval efficiency, this paper proposes a retrieval filtering method. This method achieves higher retrieval efficiency while minimizing accuracy loss. Extensive experiments were conducted on four public datasets to evaluate the proposed method, and the results validate its effectiveness. Overall, this study focuses on remote sensing image-text cross-modal retrieval and introduces the MTGFE model, which combines multimodal fusion encoding with multiple tasks to enhance the model’s ability to capture fine-grained correlations. Additionally, a retrieval filtering method is proposed to improve retrieval efficiency. Experimental results demonstrate the effectiveness of the proposed method.
On q−Gevrey Asymptotics for Logarithmic Type Solutions in Singularly Perturbed q−Difference-Differential Equations
Authors: Malek Stephane , Lastra Alberto
Published: June 2023

A family of singularly perturbed q-difference-differential equations under the action of a small complex perturbation parameter is studied. The action of the formal monodromy around the origin is present in the equation, which suggests the construction of holomorphic solutions holding logarithmic terms in both, the formal and the analytic level. We provide both solutions and describe the asymptotic behavior relating them by means of q-gevrey asymptotic expansions of some positive order, with respect to the perturbation parameter. On the way, the development of a space product of Banach spaces in the Borel plane is needed to provide a fixed point for a coupled system of equations.
Individual and Combined Influences of Copper, Cadmium and Arsenic on the Total Phenolic and Flavonoid Contents in Various Tissues of Hydrocotyle umbellata L.
Authors: Saeed Sidra Hussan , Gillani Ghulam Mujtaba Shah , Gazder Uneb , Shaheen Shahida , Almutairi Khalid F. , Avila-Quezada Graciela Dolores , Hashem Abeer , Abd_Allah Elsayed Fathi , Mahmood Qaisar
Published: June 2023

Heavy metals toxicity is a grave environmental issue in contemporary times. Phytoremediation is economic, effective and ecofriendly approach to decontaminate and remediate metal contaminated areas. Phenolic and Flavonoid content are important abiotic stress markers. The individual and combined impacts of toxiferous metals Arsenic (As), Cadmium (Cd) and (Copper) Cu were employed in recent studies to investigate their effect on Total flavonoids content (TFC) and total phenolic content (TPC) in various parts of Hydrocotyle umbellata L. to explore the role of plant in abating metal contamination. Folin- ciocalteu and AlCl 3 methods were used for investigating TPC and TFC respectively. Two-way ANOVA and CART model were employed for statistical analysis. Highest TPC was examined in decreasing order as leaf & gt; stem & gt; root in case of all the metals. Whereas highest TFC was found in all plant parts when subjected to As toxicity, and the lowest TFC was found in stem of the plant in respect to Cu toxicity. There was significant effect on TPC on plant part when subjected to Cu and As stress, but so significance was observed in plant part in case of Cd and combined metal stress. Treatment concentration had no significant effect on TPC when subjected to unique impact of all the three metals but had significant effect in case of combined metal stress. Similarly, in case of TFC no significant effect was recorded in case of plant part in all the stress types. But treatment amount has significant impact on Cd and combined metal stress. Metal type has significant effect on TPC and TFC. Whereas plant part has significant impact on TPC but non-significant values were observed on TFC in this case. This study epitomizes TPC and TFC in plants as effective and viable tool to pertain their role in phytoremediation against metal contamination. Therefore H. umbellata L. can be exerted for successful assemblage and decontamination of Cd, Cu and As in different plant parts.
Catalytic Evaluation of Hafnium Modified SiO2 for the Dehydration of Alcohols
Authors: Esteban Benito Heriberto , García Alamilla Ricardo , García Serrano Luz Arcelia , Paraguay Delgado Francisco , Carmona García Juan Antonio
Published: June 2023

The influence of hafnium metal (Hf) and sulfate ions (SO4-2) on the acidic properties of SiO2 mesopores synthesized by a non-hydrothermal method was studied using the following characterization techniques; TG-DTG, XRD, BET, SEM, TEM, EDS, FTIR, n-butylamine titration, FTIR-pyridine, and alcohol dehydration. The incorporation of 3.6% mol of Hf during the silicate synthesis step caused the characteristic structural arrangement of MCM-41 to collapse. However, an increase in the acid strength of the catalyst of up to 315 mV was observed, with Brönsted and Lewis-type acid sites being mostly present therein. Furthermore, the acidity of Hf- and (SO4-2) -modified SiO2 in the dehydration of ethanol and methanol was evaluated, resulting in a selectivity towards ethylene and dimethyl ether, respectively. Acid solids have enormous potential to produce important compounds for the chemical industry using alternative routes other than petrochemical processes. They also represent a significant advance for biorefineries.
Life’s Mechanism
Authors: Pierce Simon
Published: June 2023

The multifarious internal workings of organisms are difficult to reconcile with a single feature defining a state of ‘being alive’. Indeed, definitions of life rely on emergent properties (growth, capacity to evolve, agency) only symptomatic of intrinsic functioning. Empirical studies demonstrate that biomolecules including ratcheting/rotating enzymes, ribozymes and pigment molecules undergo repetitive conformation state changes driven by energy absorption, excitation and relaxation. They exhibit disparate structures, but govern processes relying on directional physical motion (DNA transcription, translation, ATP synthesis, cytoskeleton transport, photosynthetic resonance energy transfer) and share the principle of repetitive uniplanar conformation changes driven by thermodynamic gradients, producing dependable unidirectional motion: ‘heat engines’ exploiting thermodynamic disequilibria to perform work. Recognition that disparate biological molecules share a heat engine principle governing directional motion, working in self-regulating networks, allows a mechanistic definition: life is a self-regulating process whereby matter undergoes cyclic, uniplanar conformation state changes that convert thermodynamic disequilibria into directed motion, performing work that locally reduces entropy. ‘Living things’ are structures including autonomous networks of units operating on the heat engine principle. Death is loss of integrated heat engine function. These principles are independent of any specific chemical environment, and can be applied to other biospheres.
The Adjuvant Activity of BCG Cell Wall Cytoskeleton on Dengue Virus-2 Subunit Vaccine
Authors: Jearanaiwitayakul Tuksin , Warit Saradee , Lekjinda Kritsadayut , Seesen Mathurin , Limthongkul Jitra , Midoeng Panuwat , Sunintaboon Panya , Ubol Sukathida
Published: June 2023

The uneven immunogenicity of the attenuated tetravalent dengue vaccine has created the diffi-culty to achieve a balanced protection against all four serotypes of dengue virus (DENV). To overcome this problem, non-replicative-based vaccines have come into focus as their immuno-genicity is adjustable. This approach is excellent for multivalent vaccines but commonly faces the issue of low immunogenicity. In this present study, we developed a non-replicating dengue vaccine composing of UV-inactivated dengue-2 virus (UV-DENV2) and DENV-2 NS1-279 protein encapsidated within nanoparticles. This vaccine candidate was administered in the presence of BCG cell wall cytoskeleton (BCG-CWS) as an adjuvant. We revealed, here, that encapsidated immunogens with BCG-CWS exerted potent activities on both B and T cells and elicited Th-1/Th-2 responses in mice. This was evidenced by strong neutralizing antibody activity with an unde-tectable antibody enhancing activity in a group of mice receiving encapsidated immunogens with BCG-CWS. Importantly, BCG-CWS significantly augmented antibody-mediated comple-ment-fixing activity, strongly stimulated the antigen-specific polyfunctional T cell responses as well as activated mixed Th-1/Th-2 responses specific to DENV2- and NS1-279 antigens. In conclu-sion, BCG-CWS potently adjuvanted the inactivated DENV-2 and subunit DENV immunogens. The mechanism of adjuvanticity remains unclear. This study revealed the potential use of BCG-CWS in vaccine development.
Safety, Immunogenicity, and Antibody Persistence of COVID-19 Boosters in BBIP-CorV Immunized Individuals with Comorbidities
Authors: Ashrafian Fatemeh , Bagheri Amiri Fahimeh , Bavand Anahita , Zali Mahsan , Sadat Larijani Mona , Ramezani Amitis
Published: June 2023

Data on immunogenicity, immune response persistency, and safety of COVID-19 boosters in patients with comorbidities are limited. Therefore, we aimed to evaluate and compare three different boosters in individuals who received two doses of the BBIBP-CorV vaccine including underlying diseases and healthy cases as control.
One hundred forty subjects including 63 ones with at least one of three underlying diseases (UD) (including obesity, hypertension, and diabetes mellitus) and 77 healthy ones (HC) who had received a booster dose (either PastoCovac Plus or PastoCovac or BBIBP-CorV) were enrolled. The presence of SARS-CoV-2 antibodies was assessed before the booster injection and 28, 60, 90, and 180 days after it. Moreover, the adverse events (AEs) were recorded on days 7 and 21 post-booster shot for evaluating safety outcomes.
Significantly increased titers of anti-spike, anti-RBD, and neutralizing antibodies were observed in both UD and HC groups 28 days after the booster dose, although the titer rise of anti-spike IgG and anti-RBD IgG was insignificantly inferior in the UD group compared to the HC group. All antibodies’ titers declined, with no significant differences between the two groups over time. Notably, all specific antibodies persisted up to 180 days; particularly the neutralizing antibody in both groups. Furthermore, no significant difference in antibody levels was observed between each UD subgroup and the HC group, except for neutralizing antibodies in the hypertension sub-group. PastoCovac Plus and PastoCovac boosters induced higher antibodies’ fold rise in UD individuals than BBIBP-CorV booster recipients. Safety outcomes did not show any serious AEs after the booster injection. The overall incidence of AEs post the booster injection was higher in the UD group than the HC group. Furthermore, the highest systemic AEs rate was reported in the UD group receiving the BBIBP-CorV booster.
In conclusion, administration of COVID-19 boosters can equally induce robust and persistent humoral immune responses in individuals with or without UD primarily vaccinated with 2-doses of the BBIBP-CorV. Protein-based boosters with higher antibodies' fold rise and lower AEs in individuals with comorbidities might be considered a better choice for these individuals.
Analyzing the Scholarly Footprint of ChatGPT: Mapping the Progress and Identifying Future Trends
Authors: Farhat Faiza , Silva Emmanuel Sirimal , Hassani Hossein , Madsen Dag Øivind , Sohail Shahab Saquib , Himeur Yassine , Alam M. Afshar , Zafar Aasim
Published: June 2023

This paper presents a comprehensive analysis of the scholarly footprint of ChatGPT, an AI language model, using bibliometric and scientometric methods. The study aims to understand the evolution of research output, citation patterns, collaborative networks, application domains, and future research directions related to ChatGPT. By analyzing data from the Scopus database, 533 relevant articles were identified for analysis. The findings reveal the prominent publication venues, influential authors, and countries contributing to ChatGPT research. Collaborative networks among researchers and institutions are visualized, highlighting patterns of co-authorship. The application domains of ChatGPT, such as customer support and content generation, are examined. Moreover, the study identifies emerging keywords and potential research areas for future exploration. The methodology employed includes data extraction, bibliometric analysis using various indicators, and visualization techniques such as Sankey diagrams. The analysis provides valuable insights into ChatGPT's influence in academia and offers researchers guidance for further advancements. This study stimulates discussions, collaborations and innovations to enhance ChatGPT's capabilities and impact across domains.
Carbon Neutral City Transformation with Digitization: Guidelines from International Standardization
Authors: Ziozias Christos , Kontogianni Elli , ANTHOPOULOS Leonidas
Published: June 2023

Abstract: Establishing carbon neutrality (or Net Zero) in cities appears to be an ambitious challenge, which drives urban transformation efforts around the world to enhance people-centric living. Cities launch corresponding strategies focusing mainly on the United Nations 2030 goals to form their climate-neutral future. This paper provides practical guidance on city digital transformation to achieve carbon net zero. These guidelines illustrate actionable recommendations to reduce their carbon footprint using digital technologies. Following a multi-method research approach, findings from a bibliometric literature and a standards’ gap analysis were combined with practical evidence and circulated with focus group experts to conclude to these guidelines, which are the foundation for further standardization. The outcomes provide concrete guidelines to policymakers, planners, and other stakeholders for city digital transformation to establish carbon neutrality, via emphasizing the need for digital technologies to enhance efficiency in several areas and via leveraging green ICTs for city economic growth while also transforming citizen behavior.
Understanding In-Person and Online Exercise Oncology Program Delivery: Participant Perspectives
Authors: Duchek Delaney , McDonough Meghan , Bridel William , McNeely Margaret , Culos-Reed Nicole
Published: June 2023

Alberta Cancer Exercise (ACE) is an exercise oncology program that transitioned from in-person to online delivery during COVID-19. The purpose of this work was to understand participants’ experiences in both delivery modes. Specifically, survivors' exercise facilitators and barriers, delivery mode preference, and experience with program elements targeting behaviour change were gathered. A retrospective cohort design using explanatory sequential mixed methods was used. 57 participants completed a survey, and 19 subsequent, optional interviews were conducted. Most participants indicated preferring in-person programs (58%), followed by online (32%), and no preference (10%). There were significantly fewer barriers (i.e., commute time) (p<0.01), but also fewer facilitators (i.e., social support) (p<0.01), to exercising online. Four themes were generated from the qualitative data surrounding participant experiences in both delivery modes. Key differences in barriers and facilitators highlighted a more convenient experience online relative to a more socially supportive environment in-person. For future work that includes solely online, focusing on building social support and a sense of community will be critical to optimizing program benefits. Beyond the COVID-19 pandemic, results of this research will remain relevant as we aim to increase the reach of online exercise oncology programming to more underserved populations of individuals living with cancer.
Localized permeability of blood brain barrier for antibody-conjugates in the cuprizone model of demyelination
Authors: Abakumova Tatiana , Kuzkina Anastasia , Koshkin Philipp , Pozdeeva Daria , Abakumov Maxim , Melnikov Pavel , Ionova Klavdia , Gubskii Ilia , Gurina Olga , Nukolova Natalia , Chekhonin Vladimir P.
Published: June 2023

Development of new neurotherapeutics is strongly depending on appropriate animal model chosen in preclinical studies. A cuprizone model is an effective tool for studying demyelination and re-myelination processes in the brain, but BBB integrity in cuprizone model is still a topic for debate. Several publications claim that BBB remains intact during cuprizone-induced demyelination; others demonstrate results that could be explained by the increased BBB permeability. In our work we aim to analyze permeability of BBB for different macromolecules, particularly, antibody-conjugates in cuprizone-intoxicated mice. We compared the traditional approach using Evans blue injection with following dye extraction and detection of antibody-conjugates using magnetic resonance imaging (MRI) and confocal microscopy to analyze BBB permeability in cuprizone model. First, we validated our model of demyelination by detecting changes in gene expression of myelin basic protein and proteolipid protein, and by performing MRI and histological analysis. Our results suggest that the methods with better sensitivity were able to detect the accumulation of macromolecules (such as fluorescent-labeled or gadolinium-labeled antibody conjugates) in the brain, suggesting a local BBB disruption in the demyelinating area. These findings support previous investigations that ques-tioned BBB integrity in cuprizone model and demonstrate possibility for delivery of anti-body-conjugates to demyelinated corpus callosum
Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment Along Disease Duration
Authors: Maffezzini Sabrina , Pucci Veronica , Riccardi Alice , Montemurro Sonia , Puthenparampil Marco , Perini Paola , Rinaldi Francesca , Gallo Paolo , Arcara Giorgio , Mondini Sara
Published: June 2023

(1) Background. Cognitive impairment in people with Multiple Sclerosis (MS) has been studied in relation to some clinical variables (e.g., motor disability and disease duration) and lifestyle fac-tors such as Cognitive Reserve (CR). However, only very few studies have considered the interac-tion of clinical variables and cognitive reserve in preserving the integrity of the neuropsychologi-cal profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (2) Methods. A sample of 100 partic-ipants with MS (age range 30-74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through Generalized Additive Models. (3) Results. We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted better cognitive performance despite long disease duration, unless the motor disability was severe. (4) Conclusion. This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS.
Multiplex Real-Time RT-PCR Assays for Detection and Differentiation of Porcine Enteric Coronaviruses
Authors: Lazov Christina M. , Papetti Alice , Belsham Graham J. , Bøtner Anette , Rasmussen Thomas Bruun , Boniotti Maria Beatrice
Published: June 2023

It is important to be able to detect and differentiate between distinct porcine enteric coronaviruses that can cause similar diseases. However, the existence of naturally occurring recombinant coronaviruses such as swine enteric coronavirus (SeCoV) can give misleading results with currently used diagnostic methods. Therefore, we have developed and validated three duplex real-time quantitative RT-PCR assays for the simultaneous detection of, and differentiation between, porcine epidemic diarrhea virus (PEDV) and SeCoV. Transmissible gastroenteritis virus (TGEV) is also detected by two out of these three assays. In addition, a novel triplex assay was set up that was able to detect and differentiate between these alphacoronaviruses and the porcine deltacoronavirus (PDCoV). The validated assays have low limits of detection, close to 100% efficiency and were able to correctly identify the presence of PEDV and SeCoV in 55 field samples, while 20 samples of other pathogens did not give a positive result. Implementing one or more of these multiplex assays into the routine diagnostic surveillance for PEDV will ensure that the presence of SeCoV, TGEV and PDCoV will not go unnoticed.
Hydrogen Permeability of Composite Pd-Au/Pd-Cu Membranes and Methods for Their Preparation
Authors: Pushankina Polina , Andreev Georgy , Petriev Iliya
Published: June 2023

Thin Pd-40%Cu films were obtained by the classical melting and rolling method, magnetron sputtering and modified with nanostructured functional coatings to intensify the process of hydrogen transport. The films were modified by electrodeposition according to the classical method of obtaining palladium black and "Pd-Au nanoflowers" with spherical and pentagonal particles, respectively. The experiment results demonstrated the highest catalytic activity (89.47 mA cm–2), good resistance to CO poisoning and long-term stability of Pd-40%Cu films with a pentagonal structured coating. The investigation of the developed membranes in the hydrogen transport processes in the temperature range of 25-300°C also demonstrated high and stable fluxes up to 475.28 mmol s–1 m–2 (deposited membranes) and 59.41 mmol s–1 m–2 (dense-metal membranes), which turned out to be up to 1.5 higher compared to membrane materials with classic niello. For all-metal modified membranes, the increase in flux was up to 7 times, compared with a smooth membrane made of pure palladium, and for deposited films, this difference was several tens of times. The membrane materials selectivity was also high up to 4419. The developed strategy for modifying membrane materials with functional coatings of a fundamentally new complex geometry can shed new light on the development and fabrication of durable and highly selective palladium-based membranes for gas steam reformers.
Benefits and Challenges of Teleworking for a Sustainable Future: Knowledge Gained through Experience in the Era of COVID-19
Authors: Simeli Ioanna , Tsekouropoulos Georgios , Vasileiou Anastasia , Hoxha Greta
Published: June 2023

Since the outbreak of the Covid-19, working from home has become the norm for millions of workers worldwide. The current research focuses on the benefits and challenges of teleworking in the administrative sectors of greek healthcare units, with a view to harnessing the knowledge gained through experience, in order to create the frame for sustainable behaviors. Anyways, the implementation of teleworking requires complex and dynamic changes in technical and behavioral aspects. Therefore, a systematic review was also conducted to identify the relationships between telecommuting and organizational behavior, with the aim of achieving sustainable development in businesses. Moreover, an important positive aspect of telework that emerged from this literature review appears to create opportunities for potential direct or indirect linkages between telework and many SDGs areas, based on the fact that telework appears to be a community-friendly form of work. In summary, this research strongly suggests that leaders facilitate telecommuters to adopt green practices and volunteerism that can consequently contribute to the SDGs. However, in order to meet the challenges arising from unprecedented times, the leaders of the organizations will have to redesign their policies, while the states will have to focus on guaranteeing the rights and freedoms of the workers.
Core Fucosylation Mediated by the FucT-8 Enzyme Affects Trail-Induced Apoptosis and Sensitivity to Chemotherapy in Human SW480 and SW620 Colorectal Cancer Cells
Authors: López-Cortés Rubén , Correa Pardo Isabel , Muinelo-Romay Laura , Fernández-Briera Almudena , Gil-Martín Emilio
Published: June 2023

Epithelial cells can undergo apoptosis by manipulating the balance between pro-survival and apoptotic signals. In this work, we show that TRAIL-induced apoptosis can be differentially regulated by the expression of α(1,6)fucosyltransferase (FucT-8), the only enzyme in mammals that transfers the (1,6)fucose residue to the pentasaccharide core of complex N-glycans. Specifically, in the cellular model of colorectal cancer (CRC) progression formed using the human syngeneic lines SW480 and SW620, knockdown of the FucT-8-encoding FUT8 gene significantly enhanced TRAIL-induced apoptosis in SW480 cells. However, FUT8 repression did not affect SW620 cells, which suggests that core fucosylation differentiates TRAIL-sensitive premetastatic SW480 cells from TRAIL-resistant metastatic SW620 cells. In this regard, we provide evidence that phosphorylation of ERK1/2 kinases can dynamically regulate TRAIL-dependent apoptosis and that core fucosylation can control the ERK/MAPK pro-survival pathway in which SW480 and SW620 cells participate. Moreover, the depletion of core fucosylation sensitises primary tumour SW480 cells to the combination of TRAIL and low doses of 5-FU, oxaliplatin, irinotecan or mitomycin C. In contrast, combination of TRAIL and oxaliplatin, irinotecan or bevacizumab reinforces resistance of FUT8-knockdown metastatic SW620 cells to apoptosis. Consequently, FucT-8 could be a plausible target for increasing apoptosis and drug response in early CRC.
Characteristic Length for Pinning Force Density in Nb3Sn
Authors: Talantsev Evgeny F. , Valova-Zaharevskaya Evgeniya G. , Deryagina Irina L. , Popova Elena N.
Published: June 2023

The pinning force density FpJc,B=Jc×B (where Jc is the critical current density and B is the applied magnetic field) is one of the main parameters that characterize the resilience of a superconductor to carry a dissipative-free transport current in an applied magnetic field. Kramer (1973 J. Appl. Phys. 44 1360), and Dew-Hughes (1974 Phil. Mag. 30 293) proposed a widely used scaling law for the pinning force density amplitude: FpB=Fp,max×p+qp+qppqq×BBc2p×1-BBc2q, where Fp,max, Bc2, p, and q are free-fitting parameters. Since the late 1970-s till now, several research groups have reported experimental data on the dependence of Fp,max on the average grain size, d, in Nb3Sn-based conductors. Godeke (2006 Supercond. Sci. Techn. 19 R68) proposed that the dependence obeys the law Fp,maxd=A×ln1d+B. However, this scaling law has several problems, for instance, the logarithm is taken from a non-dimensionless variable, and Fp,maxd<0 for large grain sizes, and Fp,maxd→∞ for d→0. Here, we reanalysed the full inventory of publicly available Fp,maxd data for Nb3Sn conductors and found that the dependence can be described by Fp,maxd=Fp,max0×exp-dδ law, where the characteristic length, δ, varies within a remarkably narrow range, that is, δ=175±13 nm, for samples fabricated by different technologies. The interpretation of the result is based on the idea that the in-field supercurrent flows within a thin surface layer (thickness of δ) near the grain boundary surfaces (similar to London’s law, where the self-field supercurrent flows within a thin surface layer with a thickness of the London penetration depth, λ, and the surface is a superconductor-vacuum surface). An alternative interpretation is that δ represents the characteristic length of the exponential decay flux pinning potential from the dominant defects in Nb3Sn superconductors, which are grain boundaries.
Value of the Lymphocyte Transformation Test for the Diagnosis of Drug-Induced Hypersensitivity Reactions in Severe Hospitalized COVID-19 Patients
Authors: Fernández-Lozano Calos , Solano Solares Emilio , Elías-Sáenz Isabel , Pérez-Allegue Isabel , Fernández-Guarino Monserrat , Fernández-Nieto Diego , Díaz Montalvo Laura , González-de-Olano David , De Andrés Ana , Martínez-Botas Javier , De la Hoz Caballer Belén
Published: June 2023

In the first wave of COVID-19, up to 20% of patients had skin lesions with variable characteristics. There is no clear evidence of the involvement of the SARS-CoV-2 virus in all the cases; some of these lesions may be secondary to drug hypersensitivity. To analyze the possible cause of the skin lesions, we performed a complete allergology study on 11 patients. One year after recovery from COVID-19, we performed a lymphocyte transformation test (LTT) and Th1/Th2 cytokine secretion assays of PBMC. We included 5 nonallergic patients treated with the same drugs without lesions. Except for one patient who had an immediate reaction to azithromycin, all patients had a positive LTT to at least one of the drugs tested (azithromycin, clavulanic acid, hydroxychloroquine, lopinavir, and ritonavir). None of the nonallergic patients had a positive LTT. We found mixed Th1/Th2 cytokine secretion (IL-4, IL-5, IL-13, and IFN-γ) in patients with skin lesions corresponding to mixed drug hypersensitivity type IVa and IVb. In all cases, we identified a candidate drug as the culprit for skin lesions during SARS-CoV-2 infection, although only three patients had a positive drug challenge. Therefore, it would be reasonable to recommend avoiding the drug in question in all cases.
Sobrerol: New Perspectives to Manage Patients with Frequent Respiratory Infections
Authors: Ciprandi Giorgio , Varriccchio Attilio
Published: June 2023

Respiratory infections are usually characterized by mucus hypersecretion. This condition may worsen and prolong symptoms and signs. Mucoactive agents include different molecules with different mechanisms of action. Sobrerol is a monoterpene able to fluidify mucus, increase mucociliary clearance, and exert antioxidant activity. Sobrerol is available in various formulations (granules, syrup, nebulized, and suppository). Sobrerol has been on the market for over 50 years. Several studies investigated its efficacy and safety in acute and chronic respiratory diseases characterized by mucus hyperproduction. Seven pediatric studies have been conducted with favorable outcomes. Recently, regulatory agencies reduced the treatment duration to three days. Therefore, a future study will test the hypothesis that a combination of oral and topical sobrerol could benefit children and adults with frequent respiratory infections. The rationale considers that mucus accumulation could be a risk factor for increased susceptibility to have infections.
Cinnamon Essential Oil-Loaded Fish Gelatin-Cellulose Nanocrystals Active Films Prepared Under Acidic Conditions
Authors: Golmohammadi Abdollah , Razavi Mahsa Sadat , Tahmasebi Mohammad , Carullo Daniele , Farris Stefano
Published: June 2023

Films obtained from a main biopolymer phase of fish gelatin (GelA, 3% w/w) encapsulated with cinnamon essential oil (CEO, 0.03 – 0.48% v/w) and loaded with bacterial cellulose nanocrystals (BCNCs, 0.06% w/w) at pH = 3.5 were characterized. CEO-GelA/BCNCs films were prepared by casting and analyzed in terms of thickness, light transmittance (TT) and haze (H), surface hydrophobicity, tensile properties, chemical composition, and water solubility (WS). All tested films displayed outstanding optical properties (TT > 89.4%), with haze slightly exceeding a 3% value only when the highest CEO loading was used during nanoemulsion preparation. The CEO plasticizing effect yielded an increase in the elongation at break (EAB, from 0.84% up to 3.79%), which corresponded to a decrease in tensile strength (TS, from 8.98 MPa down to 1.93 MPa). The FT-IR spectra of films revealed a good degree of interaction among single nanoemulsion components via hydrogen bonding. The intrinsic hydrophobic nature of the CEO negatively impacted the WS (from 52.08% down to 8.48%) of the films. Results obtained in this work confirmed the possibility to produce packaging systems from renewable sources to be potentially used in the form of edible films/coatings for preserving water-sensitive food products, both vegan-based (fruits/vegetables), and animal-based (meat/seafood).
When Size Really Matters: The Eccentricities of Dystrophin Transcription and the Hazards of Quantifying mRNA from Very Long Genes
Authors: Hildyard John , Piercy Richard
Published: June 2023

At 2.3 megabases in length, the dystrophin gene is enormous: transcription of a single mRNA requires approximately 16 hours. Principally expressed in skeletal muscle, the dystrophin protein product protects the muscle sarcolemma against contraction-induced injury, and dystrophin deficiency results in the fatal muscle-wasting disease, Duchenne muscular dystrophy. This gene is thus of key clinical interest, and therapeutic strategies aimed at eliciting dystrophin restoration require quantitative analysis of its expression. Approaches for quantifying dystrophin at the protein level are well established, however study at the mRNA level warrants closer scrutiny: measured expression values differ in a sequence-dependent fashion, with significant consequences for data interpretation. In this manuscript we discuss these nuances of expression and present evidence to support a transcriptional model whereby the long transcription time is coupled to a short mature mRNA half-life, with dystrophin transcripts being predominantly nascent as consequence. We explore the effects of such a model on cellular transcriptional dynamics, and then discuss key implications for the study of dystrophin gene expression, focussing both on conventional (qPCR) and next-gen (RNAseq) approaches.
A Translation Analysis of Idiomatic Expressions in The Webtoon Comic Entitled ‘Winter Wood'
Authors: Oktaviela Szahara Gita
Published: June 2023

This study was undertaken to examine the type of idiomatic expressions, translation techniques used by translators in translating the idioms from English into Indonesian, as well as to assess the translation quality in terms of accuracy, acceptability, and readability.

This research adopted a descriptive qualitative method since the result of this study were expressed in words and sentences. Documents and informants were used as data sources. The data consisted of all idiomatic expressions in the form of phrases taken from the Webtoon comic 'Winter Woods,' while the informants were three raters who assisted in classifying the types of idioms, translation technique, and assessing translation quality in terms of accuracy, acceptability, and readability. In choosing the source of data and the raters, this study used a purposive sampling technique to select a text that has a sufficient number of idioms and informants. The data were gathered using two methods: content analysis and focus group discussion.

According to the research findings, there are 94 idioms in the 'Winter Woods' comic. It was found that 5 out of 6 types are found. They are phrasal verb, prepositional phrase, idiom with a verb as a keyword, idiom with a noun as a keyword, and idiom with an adjective as a keyword. It was discovered that the translators applied six different translation techniques to translate the idioms. They are idioms with similar meanings and forms, idioms with similar meanings but different forms, paraphrase, borrowing, omission of the idiom's play, and omission of the entire idiom.

Phrasal verb is the dominant type of idiom found in the source language because about 80 percent of verbs in English are PV. This is the reason why PV is the dominant type of idiom found in the ‘Winter Woods’ comic. Of 6 translation techniques, paraphrase is the dominant technique used by the translators to translate phrasal verb since there is no such language structure as phrasal verb in target language. According to translation quality assesment, the translation of idiomatic expressions in ‘Winter Woodss’ comic is considered as accurate, acceptable, and readable as the translators have accurately transfered the meaning of the idioms while at the same time making it easy for the target readers to understand. Furthermore, any translation techniques are welcome in translation (in this case, idiom translation) as long as the message is fully conveyed in target language.
Analysis of Directive Speech Acts in the Film "Imperfect: Karier, Cinta & Timbangan"
Authors: Astuti Harsi , Wirawati Denik
Published: June 2023

The research is motivated by the importance of knowing the actions or utterance that the speaker wishes to convey to the interlocutor. So that the interlocutor can catch the intent conveyed by the speaker. Based on this, this study aims to: (1) describe the form o directive speech acts in the film "Imperfect: Karier, Cinta & Timbangan". (2) describe the function of directive speech acts in the film "Imperfect: Karier, Cinta & Timbangan". This type of research is descriptive qualitative. The data collection method used is listening method with basic tapping techniques, advanced listening techniques free of involvement, and note-taking techniques. The data analysis method used is the pragmatic equivalent method with determining elements, and advanced comparative comparison techniques equate. The results of this study are that there are 154 data classified as follows, there are 36 data in the form of orders, 30 data in the form of requests, 17 solicitation form data, 18 data in the form of advice, 35 data in the form of criticism, and 18 data in the form of prohibilitions.
Feminism Analysis of Forms of Domestic Violence Against Women in the Novel Heartbreak Motel By Ika Natassa
Authors: Furqon Hendrik , Santi Alfika Tri Maya
Published: June 2023

Women are one of the literary objects that are always interesting to discuss. In this modern era, many women in real life experience oppression from men, so women are seen as weak by men because their lives depend on men. The focus of this research is violence against women in the household (domestic violence). Against this background, this study aims, namely (1) forms of physical violence against women; (2) forms of emotional violence against women; (3) the impact of physical violence and emotional violence on women. Method used in this study is the theory of feminism with qualitative descriptive research methods. The results of this study indicate that there are 6 analytical data on physical violence against women in Ika Natassa's novel Heartbreak Motel, 9 analytical data on emotional violence against women in Ika Natassa's novel Heartbreak Motel, and 13 analytical data on the impact of physical violence and emotional violence on women. in the novel Heartbreak Motel by Ika Natassa.
THE EFFECT OF ARM MUSCLE EXPLOSION, HANDS EYE COORDINATION AND ACHIEVEMENT MOTIVATION ON SPIN PASS SKILLS AT DKI JAKARTA RUGBY ATHLETES
Authors: Setiawan Agus maulana , Humaid Hidayat , Setiawan Iwan
Published: June 2023

This study aims to determine the effect of Arm Muscle Explosive Power, Hand Eye Coordination and Achievement Motivation on Spin Pass Skills in DKI Jakarta Rugby Athletes. The research sample was 45 DKI Jakarta Rugby Athletes. The research approach used in this study was multivariate associative, with survey methods and test and non-test techniques. The analysis technique uses a path analysis approach at a significance level of 0.05. the conclusion of each research finding shows (1) There is a direct influence between each independent variable {Arm Muscle Explosive Power (X1), Hand Eye Coordination (X2), and Achievement Motivation (X3), (2) There is a direct effect of each independent variable {Arm Muscle Explosive Power (X1), Hand Eye Coordination (X2), and Achievement Motivation (X3) have a direct influence on Spin Pass Skills (Y)}, (3) There is an indirect effect of Arm Muscle Explosive Power (X1) through Achievement Motivation (X3) on Spin Pass Skills. (Y). There is an indirect effect of Eye-Hand Coordination (X2) through Achievement Motivation (X3) on Spin Pass Skills. (Y). Thus, Spin Pass Skills can be improved through increased Arm Muscle Explosive Power, Hand Eye Coordination and Achievement Motivation
THE INFLUENCE OF LEARNING MODEL AND IQ ON KNOWLEDGE OF A BALANCED NUTRITION HEALTHY EATING
Authors: Kecuk Tri Prasetya  , Junaidi Junaidi , Marani Ika Novitaria
Published: June 2023

This study aims to determine the effect of learning models and IQ on knowledge of a healthy balanced nutritious diet. Used an experimental research method with a treatment design by level 2x2. The results of study (1) there is a difference in the increase in knowledge of students who are given a jigsaw type cooperative learning model and guided inquiry learning model based on the value of F(OA) = 50.109 and p-value = 0,000 < 0,05. (2) There is an interaction between the learning model (factor A) and IQ (factor B) towards increasing knowledge of a healthy, nutritious and balanced diet based on the value of F(OAB) = 18.12 and p-value = 0,000 < 0,05. (3) there are differences in the knowledge of students who have a high IQ with a balanced, healthy, nutritious diet using the jigsaw cooperative learning model and the guided inquiry learning model. Based on Qhitung = 3,10 > Qtabel (0,05;4:30) = 2,89. (4) there is no difference in the knowledge of students who have a low IQ with the cooperative learning type of jigsaw and guided inquiry learning models based on the value of Qcount = 0.47 < Qtabel (0,05;4:30) = 2,89
DESIGN OF LIBRARY MANAGEMENT INFORMATION SYSTEM (SIMPUSTAKA) BASED ON LARAVEL FRAMEWORK
Authors: Syifauzzuhrah Nabillah , Zulaikha Siti , Rahmawati Desi
Published: June 2023

The objective of this study is to develop a design for SimpusTaka as a website-based library using the Laravel Framework so that a conducive, systematic and computerized system can be created at the Ksatrya Lima Satu college foundation. SimPusTaka’s design was developed from the foundation's website, library guidebooks, and the existing studies. The primary emphasis of this research centers around the three phases of the Borg & Gall model’s development. The study began with data collection through interviews and literature reviews, followed by the planning and initial development stages of SimPusTaka. The findings suggest that the researchers utilized the Borg & Gall development stages to design SimPusTaka as a foundation for creating a system for managing library information that is based on the web using the Laravel framework. During the data collection phase, the researchers conducted a thorough literature review using previous studies, guidelines for library services, and the Ksatrya Lima Satu Higher Education Foundation website. Interviews were conducted with the YPKLS school librarian. At the SimPusTaka design stage, the researcher made a list of SimPusTaka features according to the suggestions given from the data collection stage, namely homepage features, search for books, about us, librarian, survey satisfaction, contact, registration form, login.
HUBUNGAN PEMBELAJARAN DARING TERHADAP KEMAMPUAN SOSIAL EMOSIONAL ANAK TK LASIYAM SURABAYA USIA 5-6 TAHUN
Authors: Taufiqur Rofiah Rifka , Hendratno  , Hasibuan Rachma
Published: June 2023

Kindergartens that still require full attention in their learning must adapt to the existing order. This of course reduces all interactions between the teacher and the child directly, resulting in a lack of bonding between the two. This study aims to determine the relationship between online learning and social emotional abilities of Surabaya Kindergarten students aged 5-6 years. This study uses a quantitative approach. The research was conducted at Surabaya's Lasiyam Kindergarten aged 5-6 years. The population of sixty children is taken using non-probability sampling, which means that the selection of the sample is not done subjectively. The type of probability sampling used is simple random sampling chosen by lottery and the formula used to take the sample is the slovin formula, so that in this study a sample of 40 was obtained. Data analysis techniques are interpreted using SPSS. The results show that the significance value is 0.032 <0.05, the significant result is less than 0.05 indicating that the hypothesis is accepted so that it shows a relationship. So it can be concluded that there is a significant relationship between online learning and children's social emotional abilities.
Implementation of Digital Marketing E-Commerce in Innovative Products of Processed Squid as a Business Opportunity in Lamu Village
Authors: Taan Hapsawati , Mardin Herinda , Mustaqimah Nur
Published: June 2023

It is commonplace that nowadays a housewife becomes a business actor and only deals with gadgets without having a physical store with only gadgets and knowledge of e- commerce to market her selling products. With the many benefits of using e-commerce, e-commerce training was carried out to market innovative products processed by squid as a business opportunity for fishermen housewives in Lamu village, Batudaa Pantai sub-district, Gorontalo Regency. The stages in this activity include observation and interviews, activity planning, implementation, and the output is a marketplace account that has been created by activity participants. The implementation of the activity was divided into 2 sessions, namely session 1 providing material related to the general description of e-commerce and session 2 conducting hands-on practice on creating a marketplace accompanied by a community service team. The e-commerce training by creating a marketplace account and selling processed squid products for fishermen housewives was successfully carried out and received great appreciation and enthusiasm from the participants and the government of Lamu village. This is a business opportunity for fishermen housewives as well as adding knowledge and insight for participants to use e-commerce in selling processed squid products.