bluuebunny/crossref_metadata_2025 huggingface dataset:
Achieving Quality Reproducible Results and Maintaining Compliance in Molecular Diagnostic Testing of Human Papillomavirus
Authors: Seabrook Jacqueline M. , Hubbard Roger A.
Published: February 2021

Laboratories contemplating either the addition of new molecular tests or modifying methods approved by the Food and Drug Administration for human papillomavirus testing should be aware of a variety of procedural, performance, and regulatory issues surrounding such activity. Diagnostic medical laboratory testing in the United States is regulated by the Centers for Medicare and Medicaid Services, an agency formerly known as the Health Care Finance Administration. The regulatory vehicle of the Centers for Medicare and Medicaid Services is manifested in the Clinical Laboratory Improvement Amendments (CLIA). The CLIA program has put into place specific regulations for laboratory quality control, which includes specific recommendations for method validation. Regulations that must be followed regarding personnel, quality control, quality assurance, method validation, and proficiency testing depend on the complexity category of the individual test. All molecular diagnostic tests, including those for human papillomavirus, are considered high complexity. The Centers for Medicare and Medicaid Services retains the authority to allow private, national accreditation organizations to “deem” that a laboratory is compliant with CLIA '88 requirements. Accreditation organizations, such as the Joint Commission for Accreditation of Hospitals, the Commission on Office Laboratory Accreditation, and the College of American Pathologists (CAP), as well as several state medical laboratory–accrediting agencies, possess the authority to deem laboratories as “CLIA-approved.” The CAP, through its Laboratory Accreditation Program, has promoted standards for laboratory performance and method validation. In general, guidelines set forth in the CAP Laboratory Accreditation Program checklists specify that all clinical laboratory testing must essentially meet those requirements defined for high-complexity testing under CLIA '88, including test validation standards, reportable/reference ranges, performance criteria, and proficiency testing.
Climate change education: the need for comprehensive climate change education in environmental public health curriculum
Authors: Boyko Maddy , Desak Tatianna , Fleming Christy , Diplock Ken , Pons Wendy
Published: February 2021

Climate change is a significant issue impacting human and environmental health. Public health professionals will play an important role in responding to this crisis. This research investigated the need for enhanced climate change education for those in a Canadian Institute of Public Health Inspector (CIPHI)-accredited post-secondary program. In February 2020, a web-based survey was sent to public health professionals via the Ontario Branch of the CIPHI and the Association of Supervisors of Public Health Inspectors in Ontario listservs. The survey explored the climate change subject areas most relevant to public health work, reflections of public health professionals’ own climate change education, and opportunities for improvements in climate change education. The results showed most public health professionals are aware of climate change’s relationship to human health, recognize its impacts in their field, and believe in the value of climate change education. Understanding climate change impacts within this public health profession and the need for climate change education can influence future curricula for prospective public health professionals, resulting in professionals entering the field prepared to tackle the challenges of the future.
The model of English language learning of the sport students
Authors: Đorić Valentina
Published: February 2021

The knowledge of an English language is one of the crucial skills for any person in the field of sport. The multicultural diversity at international competitions and a large number of sports professionals working and competing worldwide created a bigger demand for a more adequate level of linguistic knowledge. Therefore, as a result of it, it is crucial to develop a model of learning English at the institutions of higher education where the focus will be on practicing the communication competence in the field of physical culture that would primarily be context based. This means that the learning environment and the curriculum should be organized in such a way that the students are placed in different situations where they will have real life simulations of the different situations in sport or training. The important part of this model would also be the cultural aspect of language learning which would contribute to the development of intercultural communicative competence.
The status of prolonged grief disorder in the international classification of diseases (ICD-11)
Authors: Belopavlović Radomir , Novović Zdenka
Published: February 2021

Grief due to loss of a significant other is a universal experience. However, within a small, but a significant group of individuals, this process can last longer than the culturally expected period, and it can be associated with the intense distress, dysfunction, and higher rates of mortality and morbidity. Grief has been observed in the scientific literature as an adaptive reaction to loss, but also as a factor associated with major depressive disorder, generalized anxiety disorder, and post-traumatic stress disorder. Previous versions of diagnostic systems, namely DSM-IV and ICD-10, have allocated the phenomenon of prolonged grief as a condition that requires further research, or the condition that requires care. There is a recommendation not to give a diagnosis of a depressive episode because of the normative nature of the reaction to loss. In the new iterations of classification manuals, the ICD-11, this condition is classified as the Prolonged grief disorder. The rationale for change is found in the studies which suggest that this disorder is phenomenologically different from similar states. It aggregates different risk factors and consequences, as well as different treatment solutions. This paper will focus on the criteria of the disorder in the ICD-11 space, researches which mention diagnosis validity, implications, and a broader frame for conceptual and clinical utility of this disorder.
A prática docente efetivada na perspectiva da experimentação e da interdisciplinaridade através da temática água e sua biodiversidade em aulas para o Ensino Fundamental
Authors: De Fátima Lopes de Freitas Naira , Rosa Medeiros Denise , Elisângela Jappe Goi Mara
Published: February 2021

Este trabalho é resultante de elaboração e implementação de uma sequência de aulas, com perspectiva interdisciplinar, complementadas pelo desenvolvimento de atividades experimentais, norteadas pelas temáticas da água e biodiversidade aquática, como requisito do componente curricular Cotidiano da Escola – Grupo de Estudos Orientados (GEO) e das atividades de Regência do Programa Residência Pedagógica, da Universidade Federal do Pampa (UNIPAMPA), campus Caçapava do Sul, RS. Nesse contexto, foram ministradas aulas e práticas junto a uma turma do 6º Ano do Ensino Fundamental de uma escola da rede pública estadual. Objetivando contemplar a proposta, foram efetivadas vinte e quatro aulas; tais intervenções caracterizaram-se por um viés interdisciplinar coadunando-se a atividades de caráter experimental. A experiência docente desenvolvida no estágio encontrou na interdisciplinaridade uma metodologia capaz de abranger a temática da água conectando conteúdos de diferentes disciplinas, exigindo da licencianda buscar e planejar recursos didáticos criativos e adequados para a organização das atividades e para a formulação de situações de aprendizagem. Além disso, recorreu-se à ferramenta da experimentação com o propósito de reproduzir, em sala de aula, um ambiente de Ciência, no qual, se pretendeu uma aproximação com os conceitos relacionados à água e sua biodiversidade, assim como, percebeu-se uma conscientização sobre a temática ambiental.
Palavras-chave: Ensino. Biodiversidade. Abordagem interdisciplinar do conhecimento na educação.
PROJETO EMI: ENSINO E PROJETO DE EXTENSÃO COM PARTICIPAÇÃO SOCIAL NO MUNICÍPIO DE FORQUILHINHA/SC
Authors: Vieira Jorge Luiz , Zancan Evelise Chemale , Rodrigues Vanildo
Published: February 2021

O artigo procura trazer ao debate a importância da extensão universitária como instrumento complementar às atividades acadêmicas de ensino de projeto de arquitetura. Destaca o papel da Universidade na disseminação de práticas projetuais com participação social ativa, por meio da extensão. O emprego de metodologia de participação, na elaboração do programa de projeto urbano, tem sido colocado como alternativa para que os resultados de projetos comunitários alcancem maior engajamento. Parte-se da premissa de que o grau de corresponsabilidade social, sobre qualquer espaço público, está diretamente relacionado à forma como seus cidadãos participam das decisões. O fio condutor se dá por meio de um processo mais horizontal e, portanto, menos vertical, de trocas de saberes técnicos, vernaculares e de afloramento das necessidades comunitárias sobre determinado recorte espacial. O objetivo deste trabalho é apresentar a experiência em andamento do projeto de um parque urbano em uma área de 2,53 ha, localizada em um bairro popular do município de Forquilhinha, sul de Santa Catarina. O projeto de extensão, realizado pelo Escritório Modelo Interdisciplinar de Assistência Técnica (EMI), envolveu a Universidade do Extremo Sul Catarinense (UNESC), Administração Pública local, instituição de educação especial APAE (Associação de Pais e Amigos dos Excepcionais), Cooperativa Pioneira de Eletrificação Rural (COOPERA) e a ONG "Coletivo Cultural Catavento". A metodologia compreendeu uma série de ações, destacando-se as oficinas participativas, que envolveram simultaneamente todos os agentes participantes do processo. O que se apresenta como resultado são os passos desencadeados até a realização das oficinas, os métodos de trabalho anteriores, durante e pós oficinas, o resultado programático alcançado e a resposta de projeto desenvolvida até a fase de conclusão do estudo preliminar.
Changes in the condition of woodland key habitats
Authors: Ruškytė Indrė , Brazaitis Gediminas
Published: February 2021

In Lithuania, key and potential key forest habitats (hereinafter (P)WKH) were inventoried for the first time during 2000–2004. A repeated inventory of existing and newly established habitats was carried out during 2013–2017. This study assessed changes in (P)WKH over a period of 10–15 years between the main and repeated inventory. The gathered long-term and numerous information on the key biological elements of (P)WKH, rare species (mosses, lichens, vascular plants, mushrooms, beetles and molluscs), negative factors and the most appropriate measures for the preservation of biological values were analysed. The results showed that over a period of 10–15 years, 90.5% of woodland key habitats (WKH) remained stable or improved, and the status of potential woodland key habitats (PWKH) remained stable or improved in 60.3% of all PWKHs. The most significant changes were identified in the scenarios of WKH change into potential and PWKH change into key habitats. According to the PKMB to WKH change scenario, all investigated biological elements had a significant increased tendency of 1.2–2.3 times. All investigated biological elements decreased 1.4–3.9 times according to the WKH to PKMB change scenario. During the 10–15 years period, most WKH and some PWKH confirmed their potential to conserve and enrich biodiversity in a relatively small area, thus ensuring the function of a sustainable forest landscape as rare species habitats and being part of a network of protected areas. Special attention should be given to the necessary measures for the conservation of (P)WKH biodiversity (protection against economic use and application of nature management measures), continuous monitoring of these areas, as well as the admission and implementation of the legal framework for forest habitats in the general forest management policy.
Delimiting the biological traits of the vegetation of dry rivers: the case of the ramblas of the Segura basin (SE of Spain)
Authors: Martínez-Yoshino Néstor , Suárez-Alonso María Luisa , Vidal-Abarca-Gutiérrez María Rosario
Published: February 2021

Las ramblas (ríos secos) son ecosistemas de gran relevancia en la cuenca del Segura por la extensión que ocupan. Estos ecosistemas albergan comunidades vegetales caracterizadas por la diversidad y singularidad de especies que las componen. El objetivo de este trabajo es analizar los rasgos biológicos que caracterizan estas comunidades y relacionarlos con su capacidad para provee servicios ecosistémicos a la sociedad. Los resultados obtenidos indican que las comunidades vegetales de estos ecosistemas presentan rasgos biológicos claramente terrestres y xerófilos con dominancia de formas fanerófitas y caméfitas, con diversas adaptaciones a la sequía y total inexistencia de especies helófitas. Además, más del 90% de las especies estudiadas proporcionan algún servicio ecosistémico.

Dry rivers (ramblas) are ecosystems of great relevance in the Segura Basin due to the extent they occupy. These ecosystems harbour plant communities characterized by the diversity and unique ness of the species that make it up. The objective of this paper is to analyze the biological traits that characterize these communities and relate them to its capacity to provide ecosystem services to society. The results obtained indicate that the plant communities of these ecosystems present clearly terrestrial and xerophilous biological traits with a dominance of phanerophytic and camephytic forms, with various adaptations to drought and a total absence of helophyte species. Furthermore, more than 90% of the species studied provide some ecosystem service.
¿Ilusión o realidad? El disfraz en las comedias de Marivaux
Authors: Fernández Correjes Carolina
Published: February 2021

La utilización del disfraz muestra la extrema complejidad de  las relaciones entre el ser y el parecer en las comedias de Merivaux. Un objeto basta para transformar la identidad de los personajes. En consecuencia, resulta interesante estudiar el poder del disfraz para hacer surgir la acción, crear ese doble juego de  verdad y  mentira y revelar los sentimientos de los personajes. Para ello, a través de la definición de objeto teatral propuesta por Anne Ubersfeld, intentaremos analizar en este art´ículo las dieciséis comedias en las que Marivaux utiliza los objetos para disfrazar a sus personajes y conducir la acción.

The analysis of costume shows the complexity of connection between the true and the false character’s identity in Marivaux’s comedies. It’s therefore interesting to study the object’s potentialities to help tell the story, change the character’s identity and discover love. The main aim of this work is to provide a general analysis of the costume in Marivaux’s comedies on the basis of Anne Ubersfeld’s definition in order to describe its functions and meanings.

L’exploitation du déguisement montre l’extrême complexité des rapports entre l’être et le paraître dans les comédies marivaudiennes. Un objet suffit pour transformer l’identité des personnages. Par conséquent, il est intéressant d’étudier le pouvoir du déguisement pour déclencher l’intrigue, créer ce double jeu du faux et du vrai et révéler les sentiments des personnages. Pour cela, à travers la définition d’objet théâtral proposée par Anne Ubersfeld nous allons analyser les seize comédies où Marivaux utilise les objets pour déguiser les personnages et conduire l’action.
generación de la no pertenencia: La literatura del exilio español en Francia
Authors: Rodríguez Varela Rita
Published: February 2021

El exilio de una gran parte de la población durante la guerra civil española abrió el paso a una generación de escritores exiliados, unidos por la necesidad de expresar y dar sentido a la vivencia de un trauma. Escritores que en muchas ocasiones han sido olvidados o relegados a un segundo plano por la dificultad de clasificación.

Este artículo tiene como objetivo analizar y profundizar en los diferentes temas que estos autores tratan en sus obras, tales como la experiencia de la guerra o del exilio, las consecuencias de la dualidad lingüística en su identidad, la necesidad de reconstruir la historia familiar y en el encuentro con la escritura, lenguaje liberador. A través de sus obras otorgan un nuevo significado al concepto de frontera, por lo que evaden las clasificaciones tradicionales.

The exile of a large part of the population during the Spanish civil war opened the way for a generation of exiled writers, united by the need to express and give meaning to the experience of trauma. These writers have often been forgotten or relegated to the background because of their difficulty of classification.

This article aims to analyze and delve into the different topics that these authors dealt with in their works, such as the experience of war or exile, the consequences of linguistic duality on their identity, the need to reconstruct family history and in the encounter with writing, a liberating language. Through their Works they gave a new meanig to the concept of frontier, and thus evade traditional classifications.

L’exil d’une grande partie de la population pendant la guerra civile espagnole a ouvert une voie à une génération d’écrivains exilés, unis par la nécessité d’exprimer et de donner du sens à une expérience traumatique. Ces auteurs ont souvent été oubliés ou relégués au second plan à cause de la difficulté de classification.

Cet article a pour but d’analyser et d’approfondir sur les différents thèmes que ces auteus abordent dans leurs oeuvres, tels que l’expérience de la guerre ou de l’exil, les conséquences de la dualité linguistique sur leur identité, la nécessité de reconstruire l’histoire familiale et la rencontre avec l’écriture, langage libérateur. À travers ses oeuvres, ils donnent un nouveau sens au concept de frontière et échappent aux classifications traditionnelles.
ironía del destino en las novelas de Maryse Condé
Authors: Aceituno Martínez Eduardo
Published: February 2021

La ironía del destino es un motivo fundamental y recurrente en las novelas de Maryse Condé; por ello, los diversos tipos de avatares irónicos y sus funciones y signficados respectivos constituyen el objeto de nuestro análisis. Por un lado, la ironía del destino desempeña un papel decisivo en la acción de la novela, ya que encarna a menudo la estructura básica de la intriga y es empleada para canalizar el suspense. Por otra parte, el motivo de la ironía del destino contribuye visiblemente a una exploración exhaustiva de la naturaleza humana, y en especial de las reacciones instintivas e irracionales ante el fracaso y la frustración. En definitiva, Maryse Condé convierte el relato de las paradojas del destino en una poderosa herramienta narrativa y en un resorte que permite sacar a relucir ricos matices psicológicos.  

The irony of fate is a major and recurrent motif in Maryse Condé’s novels; this is why the different types of ironic transformations and their respective meanings and functions will be the subject of our analysis. On the one hand, the irony of fate plays a decisive role in the narrative action of the novel, since it frequently incarnates the weight-bearing structure of the plot, and favours the channelling of suspense. On the other hand, the topic of the irony of fate evidently contributes to a deep exploration of human nature, specifically of the instinctive and irrational reactions to failure and frustration. Ultimately, Maryse Condé exploits the narration of the paradoxes of life as a powerful narrative tool which enables her to enlighten some rich psychological nuances.

L’ironie du sort est un motif fondamental et récurrent dans les romans de Maryse Condé ; c’est pourquoi les divers types d’avatars ironiques et leurs sens et fonctions respectifs font l’objet de notre analyse. D’un côté, l’ironie du sort joue un rôle décisif dans l’action du roman, car elle incarne souvent la structure portante de l’intrigue et sert à canaliser le suspense. D’autre part, le motif de l’ironie du sort contribue visiblement à une exploration poussée de la nature humaine, notamment des réactions instinctives et irrationnelles face à l’échec et à la frustration. En définitive, Maryse Condé fait du récit des paradoxes du destin un puissant outil narratif et un ressort permettant de mettre en lumière de riches nuances psychologiques.
Verbos de movimiento en un diccionario bilingüe sintáctico-combinatorio francés-español: TACTICOMB
Authors: Sanz Espinar Gemma
Published: February 2021

Después de que Talmy (1985) y Slobin (2004) identificaran la existencia de tendencias en la conceptualización y la lexicalización de eventos de movimiento en las distintas lenguas, ha habido mucha investigación en esta materia en distintas áreas: Lingüística, Traducción, Adquisición de la Lengua Materna o Extranjera y Didáctica de las lenguas extranjeras. Como señalaba Slobin, la expresión del movimiento puede hacerse según las lenguas mediante la codificación de la trayectoria del movimiento o de la manera del movimiento en el verbo (Talmy), pero este no es el ´unico factor que permite explicitar cierta información o dejar otra implícita y conseguir un enunciado totalmente aceptable en una lengua. Nuestro objetivo es trasladar este tipo de conocimiento léxico a un diccionario sintáctico-combinatorio bilingüe, TACTICOMB, para una clase semántica de verbos que no parece implicar, en sus significados más "literales" ninguna combinatoria restringida (colocaciones), como la que puede verse en la mayoría de diccionarios de combinatoria.

After Talmy (1985) and Slobin (2004) highlighted the existence of tendencies in conceptualization and lexicalization of motion events in languages, there has been a lot of research on this topic in different areas: Linguistics, Translation Studies, First and Second Language Acquisition or Second Language Teaching. As Talmy points out, the expression of motion has different tendencies in languages from highlighting the trajectory of motion to highlighting the manner of motion in the verb, but this is not the only factor (linguistic) that allows to make some notions explicit or to keep others implicit, in a discursively acceptable utterance (Slobin). Our aim is to try to transfer this kind of lexical knowledge into a bilingual syntactic-combinatorial dictionary, TACTICOMB, through the class of motion verbs that do not seem to involve, in their “literal” senses, a restricted combinatory (collocations) as appears in many combinatory dictionaries.

Après les études de Talmy (1985) et de Slobin (2004) montrant les tendances dans la conceptualisation et la lexicalisation des procès de mouvement dans les langues, il y a eu de nombreuses recherches à ce sujet provenant de la Linguistique, la Traduction, l’Acquisition de la langue maternelle et étrangère ou la Didactique des langues étrangères. Comme le signale Talmy, l’expression du mouvement se fait différemment selon les langues, elles expriment dans le verbe soit la trajectoire, soit la manière du mouvement. Or ce n’est pas le seul facteur qui détermine la confluence d’información sur le mouvement dans un énoncé totalement acceptable dans la langue (Slobin). Notre objectif est de transposer ce type de connaissance lexicale à un dictionnaire syntactico-combinatoire bilingue, TACTICOMB. On l’illustrera pour la classe de verbes de mouvement qui ne semblent pas impliquer de combinatoire restreinte, dans leurs acceptions « littérales », comme c’est le cas pour beaucoup des dictionnaires de combinatoire.
El grafiti en la era digital
Authors: Del Pino Méndez Marta
Published: February 2021

Este trabajo aspira a conocer el encaje de la práctica del grafiti en el mundo digital.
Delimitado el grafiti como manifestación a la manera neoyorquina y desde el estudio del contexto local radicado en Mallorca, se pretende un acercamiento a las ventajas y desventajas de esta era digital y al conocimiento de la medida en que el grafiti está adaptado a su uso. Las nuevas posibilidades de difusión, la huella digital, la cuestión de la originalidad en el mundo globalizado son temas que se abordan en este texto y que pretenden poner el foco en una práctica que conforma un acto de comunicación en los muros del que nadie está excluido, aunque su participación se vea limitada a la de simple espectador.
Reiterated periodic homogenization of integral functionals with convex and nonstandard growth integrands
Authors: Tachago Joel Fotso , Nnang Hubert , Zappale Elvira
Published: February 2021

Multiscale periodic homogenization is extended to an Orlicz-Sobolev setting. It is shown by the reiteraded periodic two-scale convergence method that the sequence of minimizers of a class of highly oscillatory minimizations problems involving convex functionals, converges to the minimizers of a homogenized problem with a suitable convex function.
Nonlinear parabolic equation having nonstandard growth condition with respect to the gradient and variable exponent
Authors: Charkaoui Abderrahim , Fahim Houda , Alaa Nour Eddine
Published: February 2021

We are concerned with the existence of solutions to a class of quasilinear parabolic equations having critical growth nonlinearity with respect to the gradient and variable exponent. Using Schaeffer's fixed point theorem combined with the sub- and supersolution method, we prove the existence results of a weak solutions to the considered problems.
Remarks on the existence of nonoscillatory solutions of half-linear ordinary differential equations, I
Authors: Naito Manabu
Published: February 2021

We consider the half-linear differential equation of the form \[(p(t)|x'|^{\alpha}\mathrm{sgn} x')' + q(t)|x|^{\alpha}\mathrm{sgn} x = 0, \quad t\geq t_{0},\] under the assumption \(\int_{t_{0}}^{\infty}p(s)^{-1/\alpha}ds =\infty\). It is shown that if a certain condition is satisfied, then the above equation has a pair of nonoscillatory solutions with specific asymptotic behavior as \(t \to \infty\).
The Impact of Heritage Tourism on Sustainable Community Development, Health and Wellbeing
Authors: Wali Nidhi , Akombi Blessing , James Paul , Waterton Emma , Saul Hayley , Yuol Anyier , Renzaho Andre
Published: February 2021

This systematic review aims to understand the impact of heritage tourism on sustainable community development, including the health and wellbeing of local host communities. The protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. It highlights the scope and methodology for the systematic review to be conducted. Studies will be included if they: (i) were conducted in English; (ii) were published between January 2000 and December 2018; (iii) used quantitative and/or qualitative methods; and (iv) analysed the impact of heritage tourism on sustainable community development and/or the health of local host communities. Data extraction will be informed by Cochrane Collaboration. The quality of evidence of the studies included will be assessed using validated tools. Findings will be summarised into themes and narrated. The systematic review will establish the impact of heritage tourism on sustainable community development including health and well-being. It also aims provide a theoretical framework which will inform recommendations to improve the life-worlds of local host communities and moderate any tensions between the expanding heritage reach of states and the maintenance of customary and traditional value systems, community governance structures, and associated community development and health benefits.
Abnormal expression of HOXD11 promotes the malignant behavior of glioma cells and leads to poor prognosis of glioma patients
Authors: Wang Jialin , Liu Zhendong , Zhang Cheng , Wang Hongbo , Li Ang , Liu Binfeng , Lian Xiaoyu , Ren Zhishuai , Zhang Wang , Wang Yanbiao , Zhang Bo , Pang Bo , Gao Yanzheng
Published: February 2021

Background

Homeobox D11 (HOXD11) plays an important role in a variety of cancers, but its precise role in gliomas remains unclear. This study aimed to explore the relationship between HOXD11 and gliomas by combining bioinformatics methods with basic experimental validation.

Materials and methods

Obtain gene expression information and clinical information of glioma and non-tumor brain tissue samples from multiple public databases such as TCGA (666 glioma samples), CGGA (749 glioma samples), GEPIA(163 glioblastoma samples and 207 normal control samples), GEO (GSE4290 and GSE15824). Nine cases of glioma tissue and five cases of normal control brain tissue were collected from the clinical department of Henan Provincial People’s Hospital for further verification. A series of bioinformatic analysis methods were used to confirm the relationship between HOXD11 expression and overall survival and clinical molecular characteristics of patients with glioma. RT-qPCR was used to verify the change of expression level of HOXD11 in glioma cells and tissues. MTT assay, colony formation assay, wound-healing assay, immunofluorescence staining, flow cytometry and western blotting were used to detect the effect of HOXD11 on the biological behavior of glioma cell line U251.

Results

The high expression of HOXD11 was significantly related to age, World Health Organization (WHO) grade, chemotherapy status, histological type, and even 1p19q codeletion data and isocitrate dehydrogenase (IDH) mutation. HOXD11, as an independent risk factor, reduces the overall survival of glioma patients and has diagnostic value for the prognosis of glioma. Gene Set Enrichment Analysis (GSEA) showed that HOXD11 was significantly enriched in cell signaling pathway such as cell cycle, DNA replication and so on. Finally, we confirmed that the knockout of HOXD11 can inhibit the proliferation and invasion of U251 glioma cells, and change the biological behavior of tumor cells by preventing the progression of cell cycle.

Conclusions

HOXD11 may be used as a candidate biomarker for the clinical application of targeted drug and prognostic assessment treatment of glioma. In addition, This study will help to explore the pathological mechanism of glioma.
Post COVID-19 Syndrome: A Literature Review
Authors: Kabi Ankita , Mohanty Aroop , Mohanty Ambika Prasad , Kumar Subodh
Published: February 2021

The COVID-19 pandemic shook the entire world in January 2020 last year and is still posing a major threat to the entire humanity. A lot of studies have been conducted studying the diagnosis and management of the disease caused by this highly contagious virus, but less is known about the Post COVID-19 sequelae. There is very limited evidence about the management of COVID-19 after the first three weeks of illness. About 10% of the patients experience prolonged illness after COVID-19. Treatment is mainly focused on reassurance, self-care, and symptomatic control. There are currently no FDA-approved treatments specifically for this condition. Clinicians and researchers have focused on the acute phase of COVID-19, but continued monitoring after discharge for long-lasting effects is needed.
A Case Study of Asset Integrity and Process Safety Management of Major Oil and Gas Companies in Malaysia
Authors: Tang Kuok Ho Daniel
Published: February 2021

Asset integrity is closely intertwined with process safety where the latter is often perceived to be equivalent or a subset of the former. In Malaysia, the requirements for offshore process safety are set by Petronas assuming exclusive rights to petroleum in the nation. It imposes and enforces these requirements on oil and gas companies entering into its production sharing contracts via the common law. Process safety management in Malaysia is strongly influenced by the US OSHA 3132 with elements comprising process safety information, process hazard analysis, operating procedures, employee participation, training, contractors, pre-startup safety review, mechanical integrity, hot work permit, management of change, incident investigation, emergency planning and response as well as compliance audits. These elements are largely included in the Mandatory Control Framework of Petronas and the trio of design, technical and operating integrity adopted in the process safety management of other oil and gas companies. These management practices align with the reiterative plan-do-check-act model. Process safety performance is also gauged with indicators suggested by international institutions such as the American Petroleum Institute. On top of the Control of Industrial Major Accident Hazards Regulations 1996 for onshore processes, this study deems that establishing statutory law for offshore installations will be beneficial to propel offshore safety in Malaysia to a greater height.
A TRAJETÓRIA DO PERDÃO NA OBRA DE HANNAH ARENDT
Authors: Correia Adriano
Published: February 2021

O objetivo deste artigo é examinar o desenvolvimento do tema do perdão na obra de Hannah Arendt, principalmente nos textos da década de 1950. Ao longo da década a autora modifica substancialmente sua compreensão da relação do perdão com o cristianismo e progressivamente situa o perdão, assim como a promessa e o poder, no centro de sua análise da ação e de suas fragilidades. Realizamos uma análise bibliográfica que percorre obras publicadas e textos inéditos e buscamos realizar uma síntese conceitual das várias características do perdão na obra da autora a partir do exame da relação da ação com a necessária reconciliação com sua imprevisibilidade.

Palavras-Chave: Perdão; Ação; Reconciliação; Hannah Arendt; Paul Ricoeur

THE TRAJECTORY OF FORGIVENESS IN THE WORK OF HANNAH ARENDT

ABSTRACT

The aim of this article is to examine the development of the theme of forgiveness in Hannah Arendt’s work, especially in the texts of the 1950s. Throughout the decade, the author substantially modifies her understanding of the relationship of forgiveness with Christianity and progressively places forgiveness, as well as promise and the power at the center of her analysis of the action and its weaknesses. We performed a bibliographic analysis that covers published works and unpublished texts and we seek to carry out a conceptual synthesis of the various characteristics of forgiveness in the author’s work from the examination of the relationship of the action with the necessary reconciliation with its irreversibility.

Key words: Forgiveness; Action; Reconciliation; Hannah Arendt; Paul Ricoeur

LA TRAJECTOIRE DU PARDON DANS L’ŒUVRE D’HANNAH ARENDT

ABSTRACT

Le but de cet article est d’examiner l’évolution du thème du pardon dans l’œuvre d’Hannah Arendt, notamment dans les textes des années 50. Tout au long de la décennie, l’auteur modifie considérablement sa compréhension de la relation entre le pardon et le christianisme et place progressivement le pardon, ainsi que la promesse et le pouvoir, au centre de son analyse de l’action et de ses faiblesses. Nous avons effectué une analyse bibliographique qui couvre les œuvres publiées et les textes non publiés et nous cherchons à réaliser une synthèse conceptuelle des différentes caractéristiques du pardon dans le travail de l’auteur, basée sur un examen de la relation entre l’action et la nécessaire réconciliation avec son irréversibilité.

Key words: Pardon; Action; Reconciliation; Hannah Arendt; Paul Ricoeur
Prevalence of and Factors Associated With Nurse Burnout in the US
Authors: Shah Megha K. , Gandrakota Nikhila , Cimiotti Jeannie P. , Ghose Neena , Moore Miranda , Ali Mohammed K.
Published: February 2021

Importance

Clinician burnout is a major risk to the health of the US. Nurses make up most of the health care workforce, and estimating nursing burnout and associated factors is vital for addressing the causes of burnout.

Objective

To measure rates of nurse burnout and examine factors associated with leaving or considering leaving employment owing to burnout.

Design, Setting, and Participants

This secondary analysis used cross-sectional survey data collected from April 30 to October 12, 2018, in the National Sample Survey of Registered Nurses in the US. All nurses who responded were included (N = 50 273). Data were analyzed from June 5 to October 1, 2020.

Exposures

Age, sex, race and ethnicity categorized by self-reported survey question, household income, and geographic region. Data were stratified by workplace setting, hours worked, and dominant function (direct patient care, other function, no dominant function) at work.

Main Outcomes and Measures

The primary outcomes were the likelihood of leaving employment in the last year owing to burnout or considering leaving employment owing to burnout.

Results

The weighted sample of 50 273 respondents (representing 3 957 661 nurses nationally) was predominantly female (90.4%) and White (80.7%); the mean (SD) age was 48.7 (0.04) years. Among nurses who reported leaving their job in 2017 (n = 418 769), 31.5% reported burnout as a reason, with lower proportions of nurses reporting burnout in the West (16.6%) and higher proportions in the Southeast (30.0%). Compared with working less than 20 h/wk, nurses who worked more than 40 h/wk had a higher likelihood identifying burnout as a reason they left their job (odds ratio, 3.28; 95% CI, 1.61-6.67). Respondents who reported leaving or considering leaving their job owing to burnout reported a stressful work environment (68.6% and 59.5%, respectively) and inadequate staffing (63.0% and 60.9%, respectively).

Conclusions and Relevance

These findings suggest that burnout is a significant problem among US nurses who leave their job or consider leaving their job. Health systems should focus on implementing known strategies to alleviate burnout, including adequate nurse staffing and limiting the number of hours worked per shift.
Reassessment of the threshold of the blood lead level to increase urinary δ-aminolevulinic acid based on their relationship in recent lead workers in Japan
Authors: Ono Akira , Horiguchi Hyogo
Published: February 2021

Objectives

The present study investigated the quantitative relationship between blood lead (Pb-B) and urinary δ⁻aminolevulinic acid (ALA-U) in lead workers, and examined the Pb-B level that induces increases in ALA-U and the corresponding ALA-U.

Methods

We collected 10 562 data sets on Pb-B, ALA-U, age, and smoking habits from 808 workers (771 males and 37 females) who underwent multiple lead poisoning medical examinations at a lead-acid battery and lead smelting plant in Japan between 1995 and 2018. Females were excluded, and data collected in 169 subjects prior to engaging in lead work were used as the control. Pb-B and ALA-U levels were measured by graphite furnace atomic absorption spectrophotometry and high-performance liquid chromatography respectively.

Results

A significant dose-response relationship was observed between Pb-B and ALA-U based on Pb-B-classified observations of increases in ALA-U values and the prevalence of over-reference ALA-U as well as regression analyses independent of smoking habits. The results obtained revealed that the threshold of Pb-B to increase ALA-U was 25.1-35.0 µg/dL based on the significant elevation point of the prevalence of over-reference ALA-U and 16.2-22.3 µg/dL from a 3rd degree regression equation.

Conclusions

We proposed a threshold of Pb-B to increase ALA-U of 20 µg/dL and a biologically acceptable value of ALA-U of 1 mg/L, corresponding to the threshold.
The mediating effect of exhaustion in the relationship between effort-reward imbalance and turnover intentions: A 4-year longitudinal study from Sweden
Authors: Leineweber Constanze , Bernhard-Oettel Claudia , Eib Constanze , Peristera Paraskevi , Li Jian
Published: February 2021

Objectives

Earlier studies suggest that imbalance between effort and reward at work associates with exhaustion. Others have found that exhaustion increases turnover intentions; an important precursor of actual turnover that also associates with counterproductive work behaviors. Few, however, have studied the associations between effort-reward imbalance (ERI) and employees’ intentions to leave their current employment, and whether exhaustion is underpinning that relationship. Here, we investigate the mediating role of exhaustion in the effort-reward imbalance – turnover intentions relationship.

Methods

Data from three waves covering a time span of four years from the Swedish Longitudinal Occupational Survey of Health (SLOSH) were analysed using structural equation modeling. Cross-lagged mediation analyses were conducted to estimate if associations from ERI to subsequent turnover intentions were mediated by exhaustion. Other causal directions (direct and reversed direct effects, reversed mediation) were also examined.

Results

A direct path from ERI T1 to turnover intentions T2 was found, but not from ERI T2 to turnover intentions T3. Additionally, results showed that ERI at time points T1/T2 associated significantly with exhaustion two years later (T2/T3). Also, exhaustion at T1 showed a small but statistically significant direct association with turnover intentions at T2 (no association was found between exhaustion T2 and turnover intentions T3). A small, but statistically significant indirect effect from ERI to turnover intentions was found (estimate 0.005; 95% CI 0.002-0.010).

Conclusions

Providing a good balance between effort and reward for workers is essential to protect employee health and help retain employees in the organization.
French gendarmes' ability to make inferences while listening to witnesses: Implicit and interfering information curbs their comprehension
Authors: Duran Geoffrey , Michael George A.
Published: February 2021

Forty French gendarmes from the Gendarmerie Nationale, and 40 laypersons completed two experiments to assess how they make inferences from testimonies. The first experiment targeted how inferences are made when the critical information on which a judgment has to be made is explicitly stated in the testimony or it is implicit and has to be inferred. The second experiment assessed the comprehension of statements when critical information about an event described by a witness was directly and clearly available in the testimony or embedded within irrelevant information and personal thoughts of the witness. Results showed that gendarmes had fewer false alarms than laypersons when the statements were explicit but had as many false alarms as laypersons when information was implicit and had to be inferred. It was also found that gendarmes had fewer false alarms than laypersons when the critical information was not embedded within irrelevant information but had as many false alarms as laypersons when irrelevant information was present. This study shows that being a gendarme involves better understanding of testimonies, but only as long as testimonies do not contain redundant, interfering, and implicit information. Otherwise, this superiority is lost.
Design of Smart Antibody Mimetics with Photosensitive Switches
Authors: He Lian , Tan Peng , Huang Yun , Zhou Yubin
Published: February 2021

As two prominent examples of intracellular single‐domain antibodies or antibody mimetics derived from synthetic protein scaffolds, monobodies and nanobodies are gaining wide applications in cell biology, structural biology, synthetic immunology, and theranostics. Herein, a generally applicable method to engineer light‐controllable monobodies and nanobodies, designated as moonbody and sunbody, respectively, is introduced. These engineered antibody‐like modular domains enable rapid and reversible antibody–antigen recognition by utilizing light. By the paralleled insertion of two light‐oxygen‐voltage domain 2 modules into a single sunbody and the use of bivalent sunbodies, the range of dynamic changes of photoswitchable sunbodies is substantially enhanced. Furthermore, the use of moonbodies or sunbodies to precisely control protein degradation, gene transcription, and base editing by harnessing the power of light is demonstrated.
Highly Efficient Osmotic Energy Harvesting in Charged Boron‐Nitride‐Nanopore Membranes
Authors: Pendse Aaditya , Cetindag Semih , Rehak Pavel , Behura Sanjay , Gao Haiqi , Nguyen Ngoc Hoang Lan , Wang Tongshuai , Berry Vikas , Král Petr , Shan Jerry , Kim Sangil
Published: February 2021

Recent studies of the high energy‐conversion efficiency of the nanofluidic platform have revealed the enormous potential for efficient exploitation of electrokinetic phenomena in nanoporous membranes for clean‐energy harvesting from salinity gradients. Here, nanofluidic reverse electrodialysis (NF‐RED) consisting of vertically aligned boron‐nitride‐nanopore (VA‐BNNP) membranes is presented, which can efficiently harness osmotic power. The power density of the VA‐BNNP reaches up to 105 W m−2, which is several orders of magnitude higher than in other nanopores with similar pore sizes, leading to 165 mW m−2 of net power density (i.e., power per membrane area). Low‐pressure chemical vapor deposition technology is employed to uniformly deposit a thin BN layer within 1D anodized alumina pores to prepare a macroscopic VA‐BNNP membrane with a high nanopore density, ≈108 pores cm−2. These membranes can resolve fundamental questions regarding the ion mobility, liquid transport, and power generation in highly charged nanopores. It is shown that the transference number in the VA‐BNNP is almost constant over the entire salt concentration range, which is different from other nanopore systems. Moreover, it is also demonstrated that the BN deposition on the nanopore channels can significantly enhance the diffusio‐osmosis velocity by two orders of magnitude at a high salinity gradient, resulting in a huge increase in power density.
Exfoliation of Alpha‐Germanium: A Covalent Diamond‐Like Structure
Authors: Gibaja Carlos , Rodríguez‐San‐Miguel David , Paz Wendel S. , Torres Iñigo , Salagre Elena , Segovia Pilar , Michel Enrique G. , Assebban Mhamed , Ares Pablo , Hernández‐Maldonado David , Ramasse Quentin , Abellán Gonzalo , Gómez‐Herrero Julio , Varela Maria , Palacios Juan José , Zamora Félix
Published: February 2021

2D materials have opened a new field in materials science with outstanding scientific and technological impact. A largely explored route for the preparation of 2D materials is the exfoliation of layered crystals with weak forces between their layers. However, its application to covalent crystals remains elusive. Herein, a further step is taken by introducing the exfoliation of germanium, a narrow‐bandgap semiconductor presenting a 3D diamond‐like structure with strong covalent bonds. Pure α‐germanium is exfoliated following a simple one‐step procedure assisted by wet ball‐milling, allowing gram‐scale fabrication of high‐quality layers with large lateral dimensions and nanometer thicknesses. The generated flakes are thoroughly characterized by different techniques, giving evidence that the new 2D material exhibits bandgaps that depend on both the crystallographic direction and the number of layers. Besides potential technological applications, this work is also of interest for the search of 2D materials with new properties.