bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanistic Insights into the Neuroprotective Effects of Natural Products in Diabetic Neuropathy
Authors: Ghosh Soumyadwip , Warshi Dilwar Hossain , Chowdhury Sejuti Ray , Rahaman Monosiz , Ghosh Sourav
Published: October 2024

Diabetic neuropathy (DN) is one of the prominent complications of diabetes, which
can result in pain, impaired movement, and even amputation. There are different types of DN,
which can cause pain in fatal situations. In addition to altering insulin signaling, hyperglycemia
and dyslipidemia cause a number of pathological changes in vascular cells, glia, as well as in neurons
that can cause nerve damage and, in the end, neuropathy. Diabetic neuropathy has a poor
prognosis since it doesn't show symptoms for years after diabetes starts. Despite the abundance of
medications on the market, pharmacological ineffectiveness and a wide spectrum of adverse effects
restrict adherence. As a result, there is a growing need to find novel compounds that show
promising effects in the management of severe pain disorders. The most promising sources of
novel chemical entities with potential use in medicine continue to be plant-derived products.
Those products influenced the various signaling pathways, including PI3K/AKT pathway, MAPK
pathway, Oxidative stress, TNF-α signaling, cyclo-oxygenase (COX 2) pathway and other molecular
pathways to act as novel therapeutics for diabetic neuropathy. Basically, this mechanistic
approach is implemented to improve neuroprotective activity, especially phytoconstituents derived
from bioactive compounds. As neurodegenerative diseases have a complicated pathogenesis,
the medications that are available on the market only treat the symptoms. Therefore, it would
be highly desirable to design pharmacophores for the management of DN, with bioactive substances
that have strong neuroprotective effects, using a multi-target strategy.
Removal of Hexavalent Chromium (Cr6+) from Aqueous Solutions by Chitosan-halloysite Nanotubes Composite Hydrogel Beads
Authors: Edebali Serpil , Kahraman Havva Tutar , Karakaya Muazzez Celik
Published: October 2024

Background:

In recent years, low-cost biomaterials have been used for sustainable applications
to reduce the impact of wastewater treatment. The preparation of bio-based materials with a
strong affinity for chromate plays a crucial role in the adsorption process.

Methods:

In this study, chitosan-halloysite nanotubes composite hydrogel beads (Ch-HNTs) were
prepared for the removal of hexavalent chromium (Cr6+) from aqueous solutions. Ch-HNTs hydrogel
beads were generated by incorporating HNTs into chitosan using a glutaraldehyde solution to
achieve efficient crosslinking. The structure of the Ch-HNTs was characterized by SEM and FTIR
analysis. These novel adsorbents were then tested for the adsorption of Cr6+ in serial batch experiments.
For this purpose, the effect of pH, contact time, temperature, concentration of adsorbate, and
adsorbent concentration on the extent of adsorption were investigated.

Results:

It is proposed that Ch-HNTs can be potential adsorbents for Cr6+ removal from dilute
solutions. Nonetheless, further studies on adsorbing and removing various heavy metals using these
novel beads in column systems can be planned.

Conclusion:

It is proposed that Ch-HNTs can be potential adsorbents for Cr6+ removal from dilute
solutions. Nonetheless, further studies on adsorbing and removing various heavy metals using these
novel beads in column systems can be planned.
Development and Validation of a High-Performance Thin-Layer Chromatography Method for the Qualitative Analysis and Quantification of Hispidulin in Hydroethanol Extract of S. barbata D. Don
Authors: Pannu Arzoo , Goyal Ramesh K.
Published: October 2024

Background:

Hispidulin, a flavonoid renowned for its diverse pharmacological activities,
is abundant in S. barbata D. Don. Given its prevalence, it is essential to establish a dependable
analytical method for quantifying hispidulin in this plant.

Methods:

This study introduces a sensitive and reliable high-performance thin-layer chromatographic
(HPTLC) method for both qualitative and quantitative analysis of hispidulin in S. barbata
D. Don. Pre-coated TLC aluminum plates were utilized, and after testing various mobile phase
combinations, the most effective separation was achieved with Toluene-ethyl acetate-formic acid
(5:4:1, v/v/v). The method underwent extensive validation for linearity, specification, instrument
precision, precision, limits of LOD and LOQ, accuracy, and robustness.

Results:

The developed method demonstrated excellent linearity over a specified concentration
range, with a determination coefficient (r2) of 0.988. A well-defined spot at Rf 0.7, corresponding
to hispidulin, was observed. The concentration of hispidulin in the hydroethanolic extract of S. barbata
D. Don was quantified as 13.02 μg/mg of extract.

Conclusion:

In conclusion, the HPTLC method presented in this study offers a simple, accurate,
and robust tool for quantitatively analyzing hispidulin in the hydroethanol extract of S. barbata D.
Don. This method is suitable for routine quality control and standardization of herbal formulations
containing S. barbata D. Don, thereby contributing to the advancement of research in natural product-
based pharmaceuticals.
Role of Phytochemicals in the Management of Atopic Dermatitis: A Comprehensive Review
Authors: Thakur Anjli , Sharma Dev Raj , Kumar Pravin , Devi Seema , Dhiman Abhishek , Koundal Monika , Verma Chandrapal Singh , Ashawat Mahendra Singh
Published: October 2024

Atopic dermatitis is a chronic inflammatory skin condition that affects millions of people
around the world. In the past decades, phytochemicals have gained attention for the treatment
of atopic dermatitis due to their inflammatory, antioxidant, and immunomodulatory properties,
which could be beneficial in alleviating the suffering associated with atopic dermatitis. Although
various conventional treatments, such as immune modulators and biologicals, are available for the
treatment of atopic dermatitis their effectiveness can be limited due to some adverse effects. The
present review aimed to explore the various phytochemicals to be identified as a complementary
and alternative treatment option for the management of atopic dermatitis. Phytochemicals offer
the potential advantage of reducing both local and systemic side effects associated with long-term
use of corticosteroids, as well as addressing the higher costs of biological drug therapies. A comprehensive
literature review was conducted using databases such as PubMed, Scopus, and Web of
Science to identify the pharmacologically proven phytochemicals for the management of atopic
dermatitis by covering articles published from 2015 to 2023. Various phytochemicals, such as berberine,
piperine, ferulic acid, baicalin, vasicine, neferine, kaempferol, α- Boswellic Acid, gallic
acid, etc., werebe highlighted for their potential therapeutic effects in atopic dermatitis. In conclusion,
phytochemicals present a promising, safe, complementary, and alternative treatment option
for atopic dermatitis management.
Network Pharmacology and Molecular Docking to Explore the
Mechanism of Action of Danxiong Huoxue Tablets for the Prevention and
Treatment of Heterotopic Ossification
Authors: Du Yikuan , Wang Zhenjie , Cai Xiaolin , Zhu Jinfeng , Wang Yuni , Wang Jinjin , Huang Peiying , Ke Wenhua , Luo Ziyi , Liu Yi , Yang Chun
Published: October 2024

Background:

Danxiong Huoxue tablets have been used clinically to prevent and treat
Heterotopic Ossification (HO) after total hip arthroplasty, but its therapeutic mechanism is not
clear.

background:

Danxiong Huoxue Tablets has been used clinically to prevent and treat heterotopic ossification (HO) after total hip arthroplasty, but its therapeutic mechanism is not clear.

Objectives:

This study investigated the potential mechanism of action of Danxiong Huoxue tablets
against HO using network pharmacology and molecular docking methods.

Methods:

The TCMID and SymMap databases and the existing literature were used to screen the
active ingredients and targets of Danxiong Huoxue tablets, and the targets of heterotopic ossification
were obtained from Gene Cards, DisGeNET, and PharmGkb databases. The PPI network diagram
was constructed using the String database and Cytoscape 3.9.1 software. Finally, the core targets
were analyzed by GO and KEGG enrichment and validated by molecular docking.

Results:

A total of 39 active ingredients and 328 corresponding targets of Danxiong Huoxue
tablets were identified, which were enriched in signaling pathways, such as PI3K/Akt and MAPK.
Molecular docking verified that there was good binding activity between the core targets and the
corresponding components.

Conclusion:

Danxiong Huoxue tablets may prevent and treat HO by acting on key targets, such as
SRC, AKT1, JUN, and TNF, and regulating the PI3K/Akt signaling pathway and MAPK signaling
pathway.
The Alpha-7 Nicotinic Receptor Positive Allosteric Modulator PNU120596 Attenuates Lipopolysaccharide-Induced Depressive-Like Behaviors and Cognitive Impairment by Regulating the PPAR-α Signaling Pathway in Mice
Authors: Alzarea Sami , Rahman Shafiqur
Published: October 2024

Background and Objective:

The brain α7 nicotinic acetylcholine receptor (α7 nAChR)
has a critical role in the pathophysiology of Major Depressive Disorder (MDD) involving neuroinflammation.
The α7 nAChR stimulation has been shown to modulate the anti-inflammatory effects
of nuclear peroxisome proliferator-activated receptor-α (PPAR-α) via its endogenous ligands in the
brain. The present study determined the effects of α7 nAChR modulator PNU120596 on PPAR-α,
an inhibitor of κB (IκB) and nuclear factor-κB (NF-κB) expression and interleukin-1β (IL-1β)
level in the hippocampus and prefrontal cortex (PFC) in an inflammatory mouse model of MDD
induced by lipopolysaccharide (LPS). We also evaluated the combined effects of PNU120596 and
GW6471, a PPAR-α antagonist, on depressive-like and cognitive deficit-like behaviors in mice.

Materials and Methods:

Male C57BL/6J mice were treated with PNU120596, followed by systemic
LPS (1 mg/kg, i.p.) administration. The effects of PNU120596 on the mRNA expression of
PPAR-α and IκB were assessed in the hippocampus and PFC using qRT-PCR following LPS administration.
Similarly, the effects of PNU120596 on the immunoreactivity of PPAR-α and NF-κB
were measured in the hippocampus and PFC using an immunofluorescence assay. Furthermore, the
effects of PNU120596 on pro-inflammatory cytokine IL-1β levels were measured in the hippocampus
and PFC using ELISA. The combined effects of PNU120596 and GW6471 were also assessed
against LPS-induced depressive-like and cognitive deficit-like behaviors using the Tail Suspension
Test (TST), Forced Swim Test (FST), and Y-maze test.

Results:

PNU120596 (4 mg/kg) significantly prevented LPS-induced dysregulation of PPAR-α,
IκB, p-NF-κB p65, and IL-1β in the hippocampus and PFC. Pretreatment with PNU120596 showed
significant antidepressant-like effects by reducing immobility time in the TST and FST. Similarly,
pretreatment with PNU120596 significantly reduced cognitive deficit-like behavior in the Y-maze
test. The antidepressant and pro-cognitive-like effects of PNU120596 were reversed by PPAR-α
antagonist GW6471 (2 mg/kg).

Conclusion:

These results suggest that PNU120596 prevented LPS-induced MDD and cognitivelike
behavior by regulating α7 nAChR/PPAR-α signaling pathway in the hippocampus and PFC.
Niosomal as Potential Vesicular Drug Nano-carriers for the Treatment of Tuberculosis (TB)
Authors: Pal Rahul , Pandey Prachi , Chawra Himmat Singh , Singh Ravindra Pal
Published: October 2024

Targeted drug delivery systems are employed to administer pharmaceutical medication,
facilitating the precise delivery of drugs to specific diseased areas. Various delivery methods utilize
carriers such as antibodies, transdermal patches, biodegradable polymers, nanoparticles (NPs), liposomes,
niosomes, and microspheres. Niosomes, on the other hand, represent a promising and innovative
category of vesicular systems. Niosomes are vesicles formed by hydrating a combination of
nonionic surfactants (NIOs) and cholesterol. These nonionic surfactant carriers serve as carriers for
both lipophilic and amphiphilic drugs. In the drug delivery system using niosomes, the medication is
enclosed within a vesicle. The niosomes in tuberculosis (TB) possess biodegradable and biocompatible
properties, are nonimmunogenic, and demonstrate versatility in their structural composition. It is
a serious and potentially contagious disease originating from the bacteria, Mycobacterium tuberculosis.
In a recent update, the WHO still estimated that the number of TB cases was 9.9 million in 2022.
The use of niosomes improves the treatment of TB through the use of much more advanced technology
and advanced drug nanocarriers. The main aim of this review paper is to summarize the structural
compositions of niosomes with silent features and various preparation methods, as well as to complete
the discussion about tuberculosis and its treatment/diagnosis. Finally, the comparison of niosomes
with liposomes and their current applications in treating TB with several niosomal-drug carriers
and treatment with niosomal formulations was performed.
An Investigation of the Factors Influencing the High Temperature Rheology of Polymers
Authors: Huang Yuming , Song Ao
Published: October 2024

Introduction:

Nowadays, polymers, as an important application material in
drilling engineering, have obvious advantages in solving the rock-carrying problem at
the bottom of deep wells, and improving the drilling speed due to their excellent viscosity
enhancement effect.

Method:

In this study, the effects of polymer type, concentration, shear time, electrolyte,
and clay on the rheological properties of polymer solutions at high temperature
and high pressure were investigated using a Fann 50SL rheometer. The experimental
results showed that, except for the polymer additive amount and clay, the increase in
shear time and the amount of salt both led to a decrease in the viscosity of the polymer
solution, with 190°C as the critical temperature above which the viscosity decreased
significantly.

Results:

The polymer solution containing formate showed higher viscosity retention
during heating and then cooling compared to chlorides. The presence of clay enhances
the reticulation of polymer molecules in the blend, which facilitates the carrying of
rock cuttings at high temperatures. In addition, regression analyses showed that the
increase in temperature resulted in an enhanced tendency for the polymer solution to
evolve from a pseudoplastic to a Newtonian type.

Conclusion:

This research provides theoretical basis and data support for developing
high-temperature polymers and formulating high-temperature drilling fluid systems.
Factors Affecting Knowledge Sharing of Accountants during the COVID-19 Pandemic: Insights from Vietnam
Authors: Hong Thien To , Thanh Tri Ho , Van Chung Dao , Jibril Abdul Bashiru
Published: October 2024

Aim:

Knowledge is one of humanity's most valuable assets, continuously deepened
and developed across various dimensions, significantly enhancing the quality of life. This study
aimed to investigate the impact of six factors on the sense of knowledge sharing among accountants
in Ho Chi Minh City during the COVID-19 pandemic. The factors examined were the following:
(1) ability to manage personal information, (2) organizational image, (3) reciprocity, (4)
loss of knowledge power, (5) characteristics of the accounting profession, and (6) legal regulations
related to COVID-19.

Method:

This quantitative research study has been built on the framework established by
Kankanhalli et al., formulating hypotheses to assess the impact of these factors on knowledge
sharing among accountants in the context of the COVID-19 pandemic in Ho Chi Minh City.

Results:

Survey data from 120 accounting professionals have indicated four of the six factors,
including organizational image, reciprocity, legal regulations related to COVID-19, and characteristics
of the accounting profession, to significantly influence knowledge-sharing consciousness
among accountants in Ho Chi Minh City.

Conclusion:

The COVID-19 pandemic has positively influenced knowledge sharing, as disruptions
in activities and changes in workflows have necessitated adaptation to new working environments.
This adaptation has compelled individuals to share knowledge to effectively adjust and
optimize their capabilities.

Limitations:

This study has been strictly quantitative, limiting in-depth analysis of some variables.
Relevant latent variables may have been excluded. Future research could employ a mixed
methods approach to address the potential gaps.
Introduction to the Role of Clinical Pharmacists in Hospital Settings
Authors: Bektay Muhammed Yunus , Sancar Mesut
Published: October 2024

Clinical pharmacists (CPs) play a crucial role in hospital settings by
providing patient-centered care and improving medication outcomes. CPs use various
tools such as medication reviews, medicine reconciliation, patient counseling, and drug
monitoring to identify and resolve drug-related problems. CPs are also involved in the
implementation of evidence-based guidelines and standards to improve the quality of
care and patient outcomes. These competencies required by CP in hospital settings
include knowledge of all pharmaceutical sciences. They must also have excellent
communication skills, be able to work as part of a multidisciplinary team, and possess
the ability to critically evaluate and apply research findings. CPs assess the
effectiveness of interventions with quality of life, health-related quality of life,
medication adherence, clinical outcome, drug utilization, readmission rate, qualityadjusted life year, cost-effectiveness, hospital length of stay, patient satisfaction, and
incidence of adverse drug events. In conclusion, the role of CP in hospital settings is
essential for improving patient outcomes and ensuring safe and effective medication
use. They play a critical role in the healthcare team by providing pharmaceutical care,
utilizing evidence-based practices, and advocating for patients. CPs are well-positioned
to make a significant impact on the quality of care and patient outcomes in hospital
settings.
Understanding e-Cigarette Addictiveness: Triangulation of Focus Group and Netnographic Data
Authors: Andreas Marike , Grundinger Nadja , Wolber Nadine , Szafran Daria , Görig Tatiana , Mons Ute , Lohner Valerie , Vollstädt-Klein Sabine , Schneider Sven
Published: October 2024

Background

Numerous studies have shown that e-cigarettes are addictive. For example, we previously showed that users of e-cigarette online forums discuss experiences of addiction in a netnographic analysis. However, it is unclear what makes e-cigarettes addictive apart from nicotine. In a focus group analysis, we recently identified 3 unique features of e-cigarettes that users linked to experiences of addiction: the pleasant taste, unobtrusiveness, and unlimited usability of e-cigarettes.

Objective

This study aimed to validate the previously identified features of e-cigarette addictive potential by triangulating data from the netnographic analysis and focus group discussions.

Methods

Drawing on a netnographic analysis of 3 popular, German-language e-cigarette forums, we studied whether experiences of addiction were linked to specific e-cigarette features. We included 451 threads in the analysis that had been coded for addictive experiences in a previous study by our team. First, we conducted a deductive analysis with preregistered codes to determine whether the features of pleasant taste, unobtrusiveness, and unlimited usability were mentioned in relation to the addictive potential of e-cigarettes in the online forums. Second, an inductive approach was chosen to identify further possible addictive features of e-cigarettes.

Results

Our deductive analysis confirmed that the features highlighted in our previous focus group study (pleasant taste, unobtrusiveness, and unlimited usability) were also frequently discussed in online forums in connection to addictive symptoms. In addition, our inductive analysis identified nicotine dosage as a significant feature linked to addiction. Users reported varying their nicotine doses for different reasons, leading to the identification of four distinct user types based on dosing patterns: (1) high doses for intermittent, (2) high doses for constant use, (3) low doses for constant use, and (4) switching between high and low doses depending on the situation.

Conclusions

Our comprehensive analysis of online forum threads revealed that users’ experiences of addiction are linked to 4 specific features unique to e-cigarettes: pleasant taste, unobtrusiveness, unlimited usability, and nicotine dosage. Recognizing these addictive features of e-cigarettes is crucial for designing cessation programs and informing public health policies to reduce the addictiveness of e-cigarettes.
Ensuring Appropriate Representation in Artificial Intelligence–Generated Medical Imagery: Protocol for a Methodological Approach to Address Skin Tone Bias
Authors: O'Malley Andrew , Veenhuizen Miriam , Ahmed Ayla
Published: October 2024

Background

In medical education, particularly in anatomy and dermatology, generative artificial intelligence (AI) can be used to create customized illustrations. However, the underrepresentation of darker skin tones in medical textbooks and elsewhere, which serve as training data for AI, poses a significant challenge in ensuring diverse and inclusive educational materials.

Objective

This study aims to evaluate the extent of skin tone diversity in AI-generated medical images and to test whether the representation of skin tones can be improved by modifying AI prompts to better reflect the demographic makeup of the US population.

Methods

In total, 2 standard AI models (Dall-E [OpenAI] and Midjourney [Midjourney Inc]) each generated 100 images of people with psoriasis. In addition, a custom model was developed that incorporated a prompt injection aimed at “forcing” the AI (Dall-E 3) to reflect the skin tone distribution of the US population according to the 2012 American National Election Survey. This custom model generated another set of 100 images. The skin tones in these images were assessed by 3 researchers using the New Immigrant Survey skin tone scale, with the median value representing each image. A chi-square goodness of fit analysis compared the skin tone distributions from each set of images to that of the US population.

Results

The standard AI models (Dalle-3 and Midjourney) demonstrated a significant difference between the expected skin tones of the US population and the observed tones in the generated images (P<.001). Both standard AI models overrepresented lighter skin. Conversely, the custom model with the modified prompt yielded a distribution of skin tones that closely matched the expected demographic representation, showing no significant difference (P=.04).

Conclusions

This study reveals a notable bias in AI-generated medical images, predominantly underrepresenting darker skin tones. This bias can be effectively addressed by modifying AI prompts to incorporate real-life demographic distributions. The findings emphasize the need for conscious efforts in AI development to ensure diverse and representative outputs, particularly in educational and medical contexts. Users of generative AI tools should be aware that these biases exist, and that similar tendencies may also exist in other types of generative AI (eg, large language models) and in other characteristics (eg, sex, gender, culture, and ethnicity). Injecting demographic data into AI prompts may effectively counteract these biases, ensuring a more accurate representation of the general population.
Bridging the Telehealth Digital Divide With Collegiate Navigators: Mixed Methods Evaluation Study of a Service-Learning Health Disparities Course (Preprint)
Authors: Doueiri Zakaria Nadeem , Bajra Rika , Srinivasan Malathi , Schillinger Erika , Cuan Nancy
Published: October 2024

BACKGROUND

Limited digital literacy is a barrier for vulnerable patients accessing health care.

OBJECTIVE

The Stanford Technology Access Resource Team (START), a service-learning course created to bridge the telehealth digital divide, trained undergraduate and graduate students to provide hands-on patient support to improve access to electronic medical records (EMRs) and video visits while learning about social determinants of health.

METHODS

START students reached out to 1185 patients (n=711, 60% from primary care clinics of a large academic medical center and n=474, 40% from a federally qualified health center). Registries consisted of patients without an EMR account (at primary care clinics) or patients with a scheduled telehealth visit (at a federally qualified health center). Patient outcomes were evaluated by successful EMR enrollments and video visit setups. Student outcomes were assessed by reflections coded for thematic content.

RESULTS

Over 6 academic quarters, 57 students reached out to 1185 registry patients. Of the 229 patients contacted, 141 desired technical support. START students successfully established EMR accounts and set up video visits for 78.7% (111/141) of patients. After program completion, we reached out to 13.5% (19/141) of patients to collect perspectives on program utility. The majority (18/19, 94.7%) reported that START students were helpful, and 73.7% (14/19) reported that they had successfully connected with their health care provider in a digital visit. Inability to establish access included a lack of Wi-Fi or device access, the absence of an interpreter, and a disability that precluded the use of video visits. Qualitative analysis of student reflections showed an impact on future career goals and improved awareness of health disparities of technology access.

CONCLUSIONS

Of the patients who desired telehealth access, START improved access for 78.7% (111/141) of patients. Students found that START broadened their understanding of health disparities and social determinants of health and influenced their future career goals.
Hidden Danger of Internet: Exploring the Influence of Socioeconomic Factors on Internet Health Information Seeking Among Academic Staff in Bayelsa State, Nigeria (Preprint)
Authors: Duanyo Tobin Violet , Udensi Esther Onyinyechi , Ojong-Ejoh Mary Uyilowhoma , Udensi Lawrence Okoronkwo , Raimi Aziba-anyam Gift , Abdulraheem Funmilayo Aishat , Ndukwu Viola Nwanyisunday , Raimi Morufu Olalekan
Published: October 2024

BACKGROUND

The increasing reliance on the internet for health information necessitates understanding various factors influencing health information-seeking behaviors and satisfaction levels among users. These insights can inform strategies to improve the quality and accessibility of health information.

OBJECTIVE

This study aimed to investigate the socio-demographic factors affecting internet health information-seeking behaviors, the types of health information sought, the timeliness and trust associated with information sources, and user satisfaction regarding online health information.

METHODS

A quantitative cross-sectional survey was conducted among 376 participants, utilizing structured questionnaires to collect data on various aspects of health information-seeking behavior. Statistical analyses, including Chi-square tests and frequency distributions, were performed to evaluate the relationships between socio-demographic factors and health information-seeking behaviors.

RESULTS

The findings revealed significant associations between the duration of teaching, health insurance status, estimated income, and the duration of employment with health information-seeking behaviors (p < 0.05). The most sought-after health information types included specific medical conditions and treatment methods. Satisfaction levels varied across categories, with a majority of respondents expressing positive sentiments toward online searches, website information sources, and the usefulness of the information received.

CONCLUSIONS

The study underscores the importance of socio-demographic factors in shaping health information-seeking behaviors and highlights the need for improved credibility and trust in online health information sources. Stakeholders in health communication should prioritize the development of reliable online health information platforms and enhance user education on navigating these resources effectively. This study contributes valuable insights into the dynamics of health information-seeking behaviors, emphasizing the critical role of socio-demographic factors and the need for high-quality, trustworthy health information in promoting informed health decisions.
Research on the Impact of Digital Inclusive Financial Development on the Income Gap between Urban and Rural Residents in Henan Province
Authors: Liang Jingbo
Published: October 2024

This paper begins with an introduction of what digital inclusive finance is; it immediately describes and analyzes the development of digital inclusive finance in Henan, and analyzes the status of disposable incomes of urban and rural residents in Henan from 2011-2021; secondly, based on the digital inclusive finance index released by Peking University from 2011-2021, and based on the panel data of the corresponding years and prefectural cities of Henan Province, it applies the Stata software, through econometric regression and other methods, to empirically analyze the relationship between the development of digital inclusive finance and the income differences between urban and rural residents, to explore the intrinsic relationship between the development of digital inclusive finance and the income differences between urban and rural residents, and to meticulously examine the impact of the coverage, depth of use, and degree of digitalization of digital inclusive finance on the income differences between urban and rural residents. Through the empirical analysis, it is found that the index of digital inclusive finance development has a significant effect on the reduction of the income gap between urban and rural residents, in which the index of the degree of digital inclusive finance digitization has a greater impact on the reduction of the gap between urban and rural residents' incomes.
Spatio-temporal distribution of Dengue, Zika and Chikungunya in Cali, Colombia: 2014-2016
Authors: Fuertes-Bucheli José F. , Pérez-Arizabaleta Gladys , Quiroz-Caicedo Andrea , Olaya Robin A. , León-Giraldo Hoover O. , Pacheco-López Robinson
Published: October 2024

Introduction: Emerging and re-emerging arboviral infections have become a public health challenge in the Americas due to their epidemic potential. Objective: To determine the spatio-temporal distribution of the dengue, Zika, and chikungunya viruses during an epidemic period in Cali, Colombia. Materials and methods: Multi-method descriptive ecological and exploratory study of confirmed and suspected cases reported to the epidemiological surveillance system between 2014 and 2016. Results: 40,168 cases were analyzed, and it was found that dengue was the most frequent arboviral infection (59.2 %). The most affected individuals were women (65 %) and those with a mean age of 34.5 years. Although arboviral infections spread out throughout the city, the three diseases were concentrated in significant groups located at the center-east and northeast areas of Cali (p<0.01; z=-203.7). Conclusions: This study identified critical zones for the three arboviral infections, which are located in areas with low socioeconomic status. Likewise, the results suggest that in addition to eco-epidemiological and bio-psychosocial factors, temperature, precipitation, and the aedic index may play an important role in the spatio-temporal behavior of these diseases. A multidisciplinary and collaborative approach is necessary, which must involve communities and authorities to implement effective control strategies, especially during epidemic periods.
AVALIAÇÃO DA TOXICIDADE, CITOTOXICIDADE E MUTAGENICIDADE DE CHANANA (Turnera ulmifolia Linn.) SOBRE O CICLO CELULAR DE Allium cepa Linn.
Authors: Oliveira Maria Auxiliadora Silva , Taíssa Braga da Silva
Published: October 2024

O objetivo deste trabalho foi avaliar os possíveis efeitos tóxicos, citotóxicos e mutagênicos de diferentes concentrações do infuso de folhas de Turnera ulmifolia Linn. através do sistema vegetal Allium cepa Linn. As cebolas foram colocadas em contato com a infusão de chanana. Os efeitos tóxicos e citotóxicos foram avaliados através da inibição do crescimento radicular. As cebolas foram colocadas em contato com a infusão de Turnera ulmifolia Linn. (T1-2,25 g; T2-4,5 g; T3-6,75g; todas colocadas em 250ml de água fervente; T4-controle negativo-água mineral e T5-controle positivo-paracetamol a 3,6 mg/mL após algum tempo as raízes foram medidas com uma régua, em seguida realizou-se avaliação histológica, utilizando o histotécnico automático para desidratação, diafanização e inclusão em parafina e por fim cortados por micrótomo e analisadas no microscópio óptico com objetiva de 40X. Os efeitos tóxicos, citotóxicos e mutagênicos foram avaliados através da inibição do crescimento radicular, dos índices mitóticos e a ocorrência de micronúcleos. Através da análise dos resultados, foi evidenciado o efeito tóxico sobre os meristemas radiculares, pois, em todos os tratamentos, as raízes tiveram seu crescimento inibido. O efeito citotóxico foi constatado pela análise das médias dos índices mitóticos, onde ficou notório que todos os tratamentos analisados apresentaram diminuição significativa na divisão celular e consequente diminuição no índice mitótico. A mutagenicidade não foi atestada devido à pequena quantia de células com micronúcleo. A infusão da planta medicinal Turnera ulmifolia Linn. sobre o ciclo celular de Allium cepa Linn. apresentou efeitos tóxicos e citotóxicos, mas não apresentou características mutagênicas.
Tentativas de suicídio por envenenamento em crianças e adolescentes no município de Uberlândia: propostas de intervenção pautadas em uma revisão de literatura
Authors: Silva Luiz Julliana , Katiane Brito Ramos  , José Henrique Pereira Nunes Caixeta  , Letícia Martins Okada  , Stefan Vilges de Oliveira
Published: October 2024

Introdução: Pelo fato de a morte ser tratada como um tabu, vários óbitos evitáveis não recebem a devida atenção e prevenção, a exemplo do suicídio, que vem aumentando na população mais jovem. Assim, este trabalho busca realizar uma análise epidemiológica municipal das tentativas de suicídio por envenenamento dentre a população jovem e propor intervenções específicas para essa casuística como forma de mitigar essa realidade. Métodos: Trata-se de um estudo epidemiológico descritivo transversal utilizando-se de dados do Sistema de Informação de Agravos de Notificação, obtida da plataforma do DATASUS e do tabulador Tabnet, além de dados do Instituto Brasileiro de Geografia e Estatística, no período de 2017 a 2021, para o município de Uberlândia, analisando-se as variáveis: faixa etária, sexo, raça, local de ocorrência e evolução do caso. Revisão de literatura: A busca na literatura foi realizada nas bases de dados: PubMed, Scielo, UpToDate, LILACS e Google Scholar seguindo-se combinações de sintaxes de busca pré-definidas. Como critérios de inclusão foram adotados: artigos publicados nos últimos 5 anos, nos idiomas português ou inglês e que fossem condizentes com o assunto do artigo. Dos 199 artigos encontrados, 20 foram selecionados. Resultados: Nas idades de 15 a 19 anos foram registrados o maior número de tentativas de suicídio, especialmente no ano de 2021, sendo maior na população branca, do sexo feminino e com ocorrência na própria residência. Na revisão sistematizada realizada, foram analisados 20 artigos sendo utilizados 06 que continham propostas de intervenção para o embasamento deste artigo. Discussão: A tentativa de suicídio em crianças e adolescentes é um agravo relevante na saúde pública que precisa de grande atenção. Para prevenção desta, deve-se promover a sua identificação precoce, a detecção de fatores de risco, a capacitação dos serviços de saúde, a vigilância e monitoramento, bem como proporcionar uma melhor qualidade de vida aos jovens.
O lugar do conhecimento antropológico: notas entre Brasil, França e Índia
Authors: Ferreira Vinicius Kauê
Published: October 2024

Neste artigo, analiso minha trajetória intelectual como antropólogo formado entre Brasil, França e Índia a fim de discutir recentes transformações da antropologia global, especialmente no que tange à sua internacionalização. Recorro ao conceito de “lugar do conhecimento” de Gyan Prakash para pensar a dimensão situada do conhecimento antropológico para além de sua localização geográfica, caracterizando-o antes como uma complexa rede de história, poder e cultura. De modo complementar, valho-me também da ideia de “política do lugar” de Purnima Mankekar, explorando como pertencimento nacional, identidade e posicionamentos políticos influenciam o papel do pesquisador no cenário global da academia. A partir da minha própria trajetória, que vai de uma origem de classe trabalhadora no Brasil ao estudo da antropologia indiana na França, examino os desafios e potencialidades de uma carreira acadêmica internacionalizada para um pesquisador do Sul Global. Ao me engajar em uma autoanálise crítica, destaco as dinâmicas de poder, as representações culturais e as expectativas sociais que impactam a mobilidade acadêmica e a produção de conhecimento entre diferentes regiões, questionando as noções tradicionais de legitimidade e autoridade intelectual no mundo acadêmico globalizado. Argumento que fazer uma antropologia entre lugares envolve a construção para si de um conhecimento móvel e descentrado, baseado num constante e fértil tensionamento entre princípios teóricos e experiências subjetivas.
Índice biológico de lodos como bioindicador en dos sistemas de tratamiento de agua residual hospitalaria en Costa Rica
Authors: Loría Naranjo Margarita , Beita Sandí Wilson
Published: October 2024

Introducción: El monitoreo biológico en los sistemas de tratamiento de aguas residuales por lodos activados ofrece resultados integrales y es una herramienta complementaria en las decisiones de control operacional. Una herramienta para ello es el Índice Biológico de Lodos (IBL), basado en protozoos, pero en Costa Rica hay pocos datos sobre este tema. Objetivo: Evaluar el IBL como herramienta de bioindicación en agua residual hospitalaria. Métodos: De febrero a abril de 2022 tomamos, en un hospital costarricense, un total 36 muestras de un sistema de tratamiento por lodos activados Convencional y de un Biorreactor de Membrana (MBR). Resultados: La eficiencia de remoción del DBO y DQO fue mayor en el MBR, sin embargo, en ambos casos la eficiencia fue alta (mayor al 85%), y esto se relaciona con los altos valores de IBL. La eficiencia de remoción nitrógeno no superó el 50% (MBR). Ningún parámetro ambiental tuvo correlación con los valores de IBL, pero la edad del lodo afectó el valor de IBL. Conclusión: Tanto en el sistema de tratamiento convencional como en el MBR, los valores promedio de IBL demuestran un buen desempeño y una alta calidad de los lodos activados.
Wyzwania logistyczne dla ukraińskiego eksportu zboża w warunkach rosyjskiej agresji militarnej
Authors: Cherevko Heorhiy
Published: October 2024

Celem badań była identyfikacja konsekwencji rosyjskiej agresji militarnej jako potężnego wyzwania dla logistyki sektora zbożowego gospodarki Ukrainy oraz nakreślenie głównych kierunków jej rozwoju w najbliższym okresie. Ogólne podejście do badania wyzwań logistycznych dla ukraińskiego eksportu zboża zostało przeprowadzone na podstawie dialektyczno-analitycznej oceny zjawisk i procesów zachodzących w kontekście badanego problemu, w optymalnym połączeniu z analizą i syntezą oraz indukcją i dedukcją, oraz abstrakcją naukową. W opracowaniu uwzględniono skutki społeczno-ekonomiczne wojny w Ukrainie na podstawie danych retrospektywnych i dokonano operatywnej oceny zmian sytuacji bieżącej z określeniem prognozy na przyszłość. Podejście to miało charakter systemowy, gdyż skutki społeczno-gospodarcze rosyjskiej agresji zbrojnej w Ukrainę w kontekście badanego problemu rozpatrywane są na poziomie krajowym, regionalnym i globalnym. Główne wyniki przeprowadzonych badań obejmują zidentyfikowane konsekwencje rosyjskiej agresji militarnej dla logistyki w sektorze zbożowym gospodarki Ukrainy oraz kierunki jej rozwoju w najbliższym czasie. Uzyskane wyniki mogą być przydatne dla twórców kierunków powojennej odbudowy gospodarki Ukrainy, w szczególności logistyki w zakresie gospodarki zbożowej i eksportu jej produktów.
Wyposażenie polskich gospodarstw domowych sprzęt do przygotowania posiłków
Authors: Czarniecka-Skubina Ewa , Moczkowska-Wyrwisz Małgorzata , Pielak Marlena , Sałek Piotr
Published: October 2024

Wraz z rozwojem cywilizacyjnym na przestrzeni lat wrasta zainteresowanie konsumentów wykorzystaniem różnych sprzętów kuchennych, które ułatwiają i przyśpieszają przygotowywanie potraw w domowej kuchni. Celem pracy było przeprowadzenie badań ankietowych dotyczących wyposażenia polskich gospodarstw domowych w sprzęt do przygotowania posiłków. Badanie przeprowadzono w okresie od stycznia do kwietnia 2023 roku w grupie 770 dorosłych respondentów na terenie Polski zróżnicowanych pod względem płci, wieku, miejsca zamieszkania. Na podstawie wyników badań własnych można stwierdzić, że do najbardziej popularnych urządzeń kuchennych wśród respondentów należały: blender oraz mikser, piekarnik elektryczny, kuchnia mikrofalowa, toster, ekspres do kawy. Ważnymi dla respondentów cechami użytkowania urządzeń kuchennych jest łatwość użycia oraz ich koszt, jak również oszczędność czasu, łatwość mycia czy rozmiar danego urządzenia. Respondenci w większości przygotowują posiłki w domu, są to głównie kobiety, które podają, że starają się gotować jak najlepiej. Jednocześnie kobiety poświęcały najwięcej czasu na przygotowywanie posiłków. Większość uczestników deklarowała umiejętność gotowania, która była związana z wykształceniem oraz osobami, z którymi mieszkają. Respondenci nabywali umiejętności kulinarne przede wszystkim od członków rodziny, rodziców i dziadków. Miejsce zamieszkania nie odgrywało istotnego wpływu na umiejętności kulinarne respondentów ani na wyposażenie kuchenne.
Wybrane charakterystyki produktów a sukces rynkowy nowych produktów spożywczych w opiniach nabywców finalnych
Authors: Białoskurski Sebastian , Wróblewska Wioletta
Published: October 2024

Artykuł ma charakter badawczy i dotyczy nowych produktów spożywczych. Celem artykułu jest określenie sposobów interpretowania przez nabywców finalnych pojęcia nowego produktu spożywczego oraz poznanie ich opinii na temat nowych wyrobów spożywczych w kontekście potencjalnych preferencji nabywców i zainteresowania produktami spożywczymi o zróżnicowanych charakterystykach. Ponadto, w artykule podjęto rozważania na temat przyczyn niskiego wskaźnika sukcesu rynkowego nowych wyrobów. W celu pozyskania danych źródłowych na temat nowych produktów zastosowano badania ankietowe. Narzędziem badawczym była elektroniczna wersja kwestionariusza ankiety (CAWI). Zasięg przestrzenny badania obejmował cały kraj. Wyniki przeprowadzonych badań wskazują, że pojęcie nowego produktu utożsamiane było przez ankietowanych przede wszystkim z produktem o zmodyfikowanym składzie. Ponadto badani poszukują głównie nowych wyrobów mających więcej zastosowań oraz zaspokajających kilka potrzeb. Niskie powodzenie rynkowe wielu nowych produktów to wynik mało wyrazistej ich oferty. Można również zauważyć, że opinie ankietowanych na temat źródeł sukcesu rynkowego wyrobów spożywczych oraz ich porażki wzajemnie ze sobą korespondują.
Expenditure on transportation in households in voivodeships in Poland from 2004 to 2021
Authors: Utzig Monika
Published: October 2024

The paper aims to identify differences and changes in household expenditure on transport by voivodeships in Poland from 2004 to 2021. Using two variables – the value and the share of household expenditures on transport – voivodeships with the lowest and highest levels of indicators were distinguished, and the coefficient of variation between voivodeships was calculated. The results show that the greatest increase in the value of household expenditure on transport was observed in Dolnośląskie, while the lowest increase was in the Lubuskie voivodeship. The value of expenditure on transport decreased significantly in the pandemic year 2020, but the share did not drop below the level observed in previous years, probably due to the overall decrease in household consumption expenditure. Differences between voivodeships in the value of households’ expenditure on transport did not shrink during the analyzed period, as evidenced by the coefficient of variation between 2004 and 2021, which did not decrease. Grouping voivodeships based on the value of household expenditure on transport showed that in some voivodeships, the situation remained stable, while expenditures increased in Dolnośląskie and Lubelskie, and decreased in Małopolskie and Podkarpackie.
The effect of citric acid on mineralisation and vascular endothelial growth factor secretion from apical papilla stem cells
Authors: Hristov Krasimir , Ishkitiev Nikolay , Miteva Marina , Dimitrova Violeta , Gigova Ralitsa , Gateva Nataliya , Angelova Liliya
Published: October 2024

Objective: To investigate the influence of citric acid on the osteogenic and angiogenic potential of stem cells from apical papillae (SCAPs).
Materials and methods: Stem cells from apical papillae were isolated from freshly extracted third permanent molars. These cells were treated with 20 and 100 μM citric acid. Alizarin red staining was used to evaluate mineral deposition. The secreted levels of vascular endothelial growth factor (VEGF) were assessed by ELISA on days 18, 24 and 28. Immunofluorescence analysis was performed to assess the expression of surface markers after exposure to 20 and 100 μM citric acid.
Results: Different mineralisation patterns were observed. Supplemented with citric acid, media showed more diffuse and less dense crystals. On day 18, most VEGF was secreted from the cells with no added citric acid. On day 24, there was a significant increase (p < 0.05) in the levels of VEGF secreted from cells treated with 20 μM citric acid. On day 28, cells from the control group did not secrete VEGF. There was a reduction in the levels of VEGF secreted by cells treated with 20 μM citric acid and a significant increase in the cells exposed to 100 μM citric acid (p < 0.05).
Conclusion: Citric acid can promote the differentiation of SCAPs and angiogenesis.
BIG BOOK: STUDENTS’ PERCEPTION OF ITS BENEFITS TO READING SKILL
Authors: Cahyani Chandrika Rahmania , Megawati Fika
Published: October 2024

This research uncovers students' perceptions of the benefits of significant books on reading skills. A purposive descriptive case study was used to explore their perceptions of the benefits of big books on reading skills and the challenges in practicing the activity. Five elementary school students who read big books became participants in this research. To fill the gap, this research aimed to describe the benefits of big books on students' reading activities. An open-ended questionnaire was used for data collection. Data were collected through structured interviews and analyzed using Interpretative Phenomenological Analysis (IPA). The results showed that students positively perceived reading using big books. They argued that this technique stimulated and encouraged their creativity. However, it was found that big book has limited verbal representation and development of other skills. This research implies that big books can enhance creativity, are easy to use, and are not fixated on technology.