bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing and Uplifting Sustainable Orality Languages in Nepal: A Case Study of Magar Kaike and Athpariya
Authors: Regmi Dan Raj , Regmi Ambika
Published: July 2022

Orality level of the languages of Nepal like Magar Kaike and Athpariya call for being evaluated within the FAMED conditions and community-based language development strategies have to be framed to increase the sustainable use of those languages from the perspective of Sustainable Use Model proposed in Lewis and Simons (2017).
Phonemic Inventory of Sikles Gurung
Authors: Ronkos Danielle
Published: July 2022

This paper describes the consonant and vowel phonemes of the variety of Gurung, or Tamu Kyui, spoken in Sikles Village. Unlike other documented varieties, Sikles Gurung is analyzed with contrastive vowel duration, word-initial obstruent voicing, and two register categories. This analysis is supported by data collected with the help of Sikles speakers living in Nepal and New York City.
Comprehensive Documentation of Mewahang
Authors: Sharma Narayan P.
Published: July 2022

The Mewahang language belongs to the Kiranti branch of the Tibeto-Burman family and is predominantly spoken in Sankhuwasabha district of eastern Nepal. No linguistic fieldwork has been undertaken so far and the language remains undescribed. The paper characterizes a first comprehensive documentation of Mewahang, and presents data collection and ethnography.
MLE Practices in Nepal: A Case of Rajbanshi
Authors: Yadav Surya Prasad
Published: July 2022

Multilingual education (MLE) is a new phenomenon in Nepalese education. It has been in practice in Nepal for almost half a decade. There exist MLE programs run by both government and non-government agencies. This paper is an attempt to undertake a case study of Rajbanshi medium school run in Jhapa district of Nepal.
Immune-Mediated Intraocular Inflammation. Review
Authors: Klímová Aneta , Brichová Michaela , Říhová Eva , Heissigerová Jarmila , Svozílková Petra
Published: July 2022

Immune mediated inflammatory diseases are categorized into autoimmune and autoinflammatory. Autoimmune etiology is represented by autoreactive lymphocytes or autoantibodies, e.g. primary Sjögren‘s syndrome or rheumatoid arthritis. Ocular specific diseases with presumed autoimmune origin are sympathetic ophthalmia or birdshot chorioretinopathy. Autoinflammatory diseases are caused by mutations in regulatory genes for specific immunity. Hereditary periodic fevers represent monogenic autoinflammatory diseases; eye specific is Blau syndrome also named sarcoidosis with early onset.
This article reviews the actual knowledge about immune mediated uveitides, their immunological mechanisms and the possible trigger role of infection in autoimmune inflammation. Immune privilege provides a protection of the eye against any strong immune reaction to foreign antigen, based on physical, immune, humoral and molecular mechanisms. Antigens hidden within the eye are revealed in case of damage of hematoretinal barrier caused by infection or mechanical insult. These ocular antigens have not been set as tolerable during the development and immune reaction is initiated subsequently.
Current studies demonstrate that uveogenic trigger might be generated by own microbiome, particularly when dysregulated, so called dysbiosis. There is a known association between idiopathic inflammatory bowel disease with ankylosing spondylitis and anterior uveitis in humans. Intensive research is focused on microbiome and immune mediated inflammatory disease to influence therapeutically the intestinal microbiome. The animal models are used to study the immunopathological mechanisms of uveitis and the new therapeutic strategies, because of relatively low incidence of immune mediated uveitis in humans.
Lateral Tarsal Strip Technique in Correction of Eyelid Ectropion and Entropion
Authors: Vydláková Jan , Tesař Jan , Krátký Vojtěch , Šín Martin , Němec Pavel
Published: July 2022

Background: Ectropion and entropion are eyelid malpositions associated with many unpleasant symptoms. One of many surgical methods that can correct these problems is called the lateral tarsal strip. In this paper, we evaluate the postoperative results and quality of this technique. We also looked at the complications associated with this surgical method.

Methods: The study took place from April 2018 to April 2020 at the Military University Hospital in Prague. The operation was performed by two surgeons. The study included 43 eyes of 33 patients (17 women and 16 men), average age was 79 years. Before the operation, 23 eyes had an ectropion and 20 eyes had an entropion, 35 of 43 were cases of involutional origin. The study does not include patients who underwent other surgical techniques.

Results: There were no intraoperative or postoperative complications in the entropion surgery group. Proper correction was achieved, and bothersome symptoms disappeared in 91,3 % of cases. Correct position of eyelid was not achieved in two cases. For patients with ectropion, surgical correction was successful in 95 % of cases. The ectropion persisted after surgery only for one patient.

Conclusion: The lateral tarsal strip technique is safe, reliable and highly effective surgical technique. Correction of eyelid malposition was achieved in more than 90 % of cases. Vast majority of patients were satisfied and reported relief from preoperative symptoms.
Retrospective Analysis Of The Presence Of Choroidal Neovascularisation Using Optical Coherence Tomography Angiography In The Treatment Of Chronic Central Serous Chorioretinopathy With The Aid Of Photodynamic Therapy
Authors: Myslík Manethová Kateřina , Ernest Jan
Published: July 2022

Purpose: Analysis of the presence of choroidal neovascularization (CNV) by optical coherence tomography angiography (OCTA) in eyes treated with photodynamic therapy in a reduced dosing regimen (HD-PDT, half dose of verteporfin) for the chronic form of central serous chorioretinopathy (cCSC).

Materials and methods: Retrospective evaluation of OCTA findings in 54 eyes of 52 patients treated for cCSC with HD-PDT. OCTA was performed on Angioplex Zeiss Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA, USA) 1 year after HD-PDT to verify changes typical of cCSC. By analyzing the results of this examination, we evaluated in particular the presence or absence of concomitant CNV and the correlation of the present CNV with the average resulting best corrected visual acuity (BCVA).

Results: We analyzed the OCTA findings of 54 eyes (52 patients), in which we demonstrated the presence of concomitant CNV in 35 eyes (35.2%). Revealed CNV occurred in 82% below the undulating hyperreflective RPE line. In eyes with CNV, the mean BCVA (72 letters ETDRS) was statistically significantly lower than in eyes without CNV (82.7 letters ETDRS) (p = 0.0179).

Conclusion: In our retrospective evaluation of a group of patients who underwent HD-PDT for cCSC, we demonstrated with OCTA the presence of CNV in 35.2 % eyes 1 year after the treatment. We believe that the presence of type I CNV is a complication of the chronic disease itself rather than an adverse effect of HD-PDT.
Diagnoses That Mimic Pachychoroid Diseases of the Macula – Case Reports
Authors: Tesař Jan , Šín Martin , Němec Pavel , Studnička Jan
Published: July 2022

Pachychoroid disease of retina is a spectrum of diseases manifested by thickening and hyperperfusion of the choroid with changes in the sensory part of the retina. The main unit of this group is central serous chorioretinopathy (CSC). In practice, we often encounter other conditions, which are manifested by thickening of the choroid and changes in the retina, but they cannot be classified as pachychoroid diseases. The aim of this study is to point out on a series of 3 case reports the difficulties in the differential diagnosis of retinal diseases in which we find thickening of the choroid.

Case report 1: 42-year-old patient treated for central serous chorioretinopathy. After optical coherence tomography (OCT), fluorescence angiography (FAG) and indocyanine green angiography (ICG) the diagnosis was changed to choroidal hemangioma and he was treated with photodynamic therapy (PDT) which led to a reduction of the hemangioma.

Case report 2: A 30-year-old patient treated for ankylosing spondylitis comes for visual impairment in the left eye. On OCT the condition resembled chronic CSC. The patient suffered from a febrile exanthema a few days ago. Serological testing for coxsackievirus was positive and the diagnosis was changed to acute chorioretinitis in coxsackievirus infection. Oral treatment with prednisone was successful.

Case report 3: A 46-year-old patient was treated conservatively for CSC. After FAG and ICG, a solitary dilated choroidal vessel was found in the area of the papillomacular bundle with leakage under the sensory epithelium which was diagnosed as choroidal macrovessel. We performed PDT with a very good anatomical effect.

Conclusion: Precise differentiation of these mentioned diseases from pachychoroid retinal diseases was essential in choosing the appropriate therapy. The use of all modern imaging methods of the retina and choroid plays a key role in determining the diagnosis.
Blow-in Fracture of Orbital Roof. A Case Report
Authors: Lubojacký Jakub , Masárová Michaela , Plášek Marek , Benda František , Komínek Pavel , Matoušek Petr
Published: July 2022

Orbital fractures may be accompanied with severe damage of the eye bulb and other intraorbital tissues. Early clinical findings can be very mild, therefore it is vital to actively seek not only for any damage done to the soft tissues of the orbit, but also for extraorbital complications such as liquorrhea or meningitis. We report a relatively rare case of blow-in fracture of orbital roof in eleven years old boy. Patient was admitted to the emergency care after falling off a bicycle without impaired consciousness. During admission ophthalmologist evaluated the condition as severe contusion of the left bulb, with hemophthalmia and retinal comotosis. Due to significant swelling of eye lids and periorbital hematoma, it was not possible to perform specific tests to objectify possible oculomotor disorder and diplopia. CT scan findings show dislocated fracture of orbital roof with fragments reaching into the musculus rectus superior. For high risk of bulbus penetration and muscle damage a surgical intervention with bone fragments removal was performed using endoscopic assisted frontal orbitotomy. After operation patient had no signs of functional eye disorder.
An Anthropological Study of Rural Poverty in Sri Lanka and the Functioning of the Samurdhi Project
Authors: Samarasekara K. M. S. , Sandarenu W. M. K.
Published: July 2022

Poverty in Sri Lanka (especially in rural areas) is a problem to the development of the country. Although various projects have been implemented to alleviate poverty, no significant progress has been made by such development projects. Samurdhi project is one of the national development projects introduced by the government to eradicate poverty. The research intends to study, how people suffering from poverty and make it as a part of their lives instead of introducing solution to minimize the poverty and to identify the new state of living which creats through it. Out of 153 Samurdhi beneficiary families in the 70/B Ambadandegama Grama Niladhari Division, Bandarawela Divisional Secretariat in the Badulla District, 30 family units were selected under the judgmental sampling method through an interview schedule as a data collection method. Poverty has been assigned as a culture is the main elicited fact of this research. Poverty has affected many aspects of their daily lives and they have inherited the cultural characteristics of poverty such as they do not planning their life style and economic activities or any other activities, excessive borrowing like 93% of the total suffer from debt, expecting further relief from the government and blaming them when relief is not forthcoming. Moreover, in order to continue receiving government subsidies, poverty is maintained and continued living with poverty without seeking for a solution. It is the culture of poverty. Therefore, Samurdhi project can be identified as a failed development project which introduced to eradicate rural poverty as a result of not accomplishing an effective impact towards the eradication of rural poverty. However, before implementing a development project, it is needed to pay attention on socio – cultural factors of the community and a planning with a proper understanding will be beneficial to make the development projects successful.
Study of the association of gene polymorphism associated with sports success and risk of occupational diseases in young football players
Authors: Denga O. V. , Osadcha A. O.
Published: July 2022

Annotation. Advances in sports genetics have opened up new opportunities in determining the propensity to perform physical activity of varying intensity and duration, as well as in the diagnosis and prevention of pathologies of athletes whose development is associated with excessive training loads. Detection of gene polymorphism makes it possible to develop personalized schemes for the prevention of various pathologies in athletes. The aim of the study was to study the genetic polymorphisms of the genes ACE (Ins/Del), ACTN3 (R577X), AMPD (Gln12Ter), UCP2 (Arg/Gly) in young football players, which cause individual differences in physical performance and susceptibility to occupational diseases. The object of the study was the genetic material of 24 football boys, the biological material for the study was DNA extracted from buccal epithelial cells. Molecular genetic analysis of genomic DNA was performed by polymerase chain reaction. Statistical surveys were performed using the software STATISTICA 6.1 to determine the average and percentage ratios. As a result of genotyping of young football players, polymorphisms of the I/D gene ACE, R577X of the ACTN3 gene, Gln12Ter of the AMPD gene and Arg/Gly of the UCP2 gene were revealed. For the ACE genotype 16.7%; 16.7%; 66.6% of players had genotypes I/I, I/D and D/D, respectively, while for ACTN3 33.3% had XX, 12.5% had RX, and 54.2% had RR genotypes. A study of the Gln12Ter (C/T) genetic polymorphism of the AMPD gene showed that 83.3% of football boys have the SS genotype. Functionally defective T-allele was found in 10.4% of children. Genotyping of the UCP2 gene (G-866A), a regulator of energy balance, found that 77% of children in this group are carriers of the G allele, and the A allele is present in 23% of boys. Thus, the identified some unfavorable genetic variants will allow to adjust the state of the organism and preventive schemes of pathology, including dental, with the help of individual medical and biological support.
The effect of modulators of hydrogen sulfide metabolism on morphological changes in kidneys of rats with high-calorie diet-induced obesity
Authors: Blazhchenko V. V. , Zaichko N. V.
Published: July 2022

Annotation. Obesity is one of the factors in the development of chronic kidney disease. Hydrogen sulfide (H2S) plays an important role in regulating the functional state of the kidneys, and its endogenous production is disrupted in obesity. The search for effective and safe correctors of H2S metabolism in the kidneys in obesity is relevant. The aim of the study was to establish the effect of potential modulators of H2S metabolism on biochemical and morphological changes in the kidneys of rats with high-calorie-diet-induced obesity (DIO). The experiments were performed on 60 white male laboratory rats in accordance with the principles of bioethics (Strasbourg, 1986; Kyiv, 2001). DIO was modeled using a high-calorie high-fat diet (39.5% fat per calorie). Metabolic correction was performed with H2S metabolism modulators (zinc sulfate, sodium thiosulfate, lipoic acid, taurine). Control rats received a standard diet (10.5% fat per calorie). Somatometric parameters, H2S level, morphological changes of kidney tissue were determined. Statistical processing was performed in the package IBM Statistics SPSS 26, differences were assessed in the Kruskel-Wallis test at a significance level of p<0.05. It was found that the development of DIO was accompanied by a decrease in the concentration of H2S in the kidneys (1.9 times, p<0.001), characteristic morphological changes in renal tissue with damage of the glomerular and tubular apparatus, severe inflammatory reaction of the parenchyma, endothelial damage and vascular structure. All metabolic correctors increased the level of H2S in the kidneys and inhibited the progression of nephropathy under the conditions of DIO. Zinc sulfate and lipoic acid were the most effective in preserving the structural elements of the renal parenchyma, while sodium thiosulfate and taurine were less effective.
Eradication of Helicobacter pylori: what determines the effectiveness antihelicobacter pharmacotherapy (according to the results of the analysis of urease breath tests performed in 2006-2019 in Vinnytsia region)
Authors: Paliy I. G. , Zaika S. V. , Kondratiuk N. M.
Published: July 2022

Annotation. One of the global challenges of modern gastroenterology, which prevents the provision of acceptable levels of eradication of Helicobacter pylori, is the problem of increasing resistance of Helicobacter pylori to previously effective antibiotic regimens. The aim of the study – evaluate the effectiveness of Helicobacter pylori eradication depending on the chosen antihelicobacter pharmacotherapy regimen and the used proton pump inhibitors. We analyzed the results of 906 urea breath tests, which were conducted to monitor the effectiveness of antihelicobacter therapy for the period from 2006 to 2019. To analyze the results obtained, the examined patients were divided into groups depending on the scheme of Helicobacter pylori eradication of and the proton pump inhibitors used. Doses, multiplicity and duration of Helicobacter pylori eradication regimens met the requirements of the then valid Maastricht Consensus. We used Student's t-test for relative values to assess significant differences between the study groups. During the period 2006-2019, there is a significant level (32.1% of all tests conducted to control antihelicobacter pharmacotherapy) of the Helicobacter pylori eradication schemes use by doctors in Vinnytsia region that do not meet the criteria of the Maastricht Consensus and are characterized by low efficiency (eradication level of Helicobacter pylori 65 %), however, since 2016 there has been a significant (p <0.01) decrease in the following appointments: 2016 – 29.4%, 2017 – 22.7%, 2018 – 14.8%, 2019 – 8.2%, respectively. Among the schemes of antihelicobacter pharmacotherapy (2006-2019), doctors of Vinnytsia region prefer the appointment of PPI + Cl + Am and PPI + Cl + Am + B (61.6% and 20.7% among all tests performed to control the eradication of H.p. respectively) with a tendency to increase the purpose of the PPI + Cl + Am + B scheme since 2016: 2016 – 22.7%, 2017 – 22.7%, 2018 – 34.1%, 2019 – 29.2%. These schemes showed the highest efficiency during the entire observation period: PPI + Cl + Am – 81.6%, PPI + Cl + Am + B - 87%. The choice of omeprazole in the eradication scheme of Helicobacter pylori based on PPI + Cl + Am + B leads to significantly (p <0.01) worse eradication results compared to pantoprazole, lansoprazole, rabeprazole and esomeprazole: 68% vs. 87.1%, 100%, 100% and 88.9% respectively.
Specific features of blood parameters in volleyball players and wrestlers in preparatory period of training cycle
Authors: Sarafyniuk L. A. , Shevchuk T. V. , Ivanov S. O. , Shevchuk N. A.
Published: July 2022

Annotation. Study of modern laboratory markers of structural and functional disturbances of muscle tissue in athletes, reflecting energy metabolism, paravertebral muscle damage, and being an indicator of body performance and muscle activity, is of undeniable practical importance for modern sports medicine. The aim of the study was to determine clinical and biochemical parameters of blood in volleyball players and wrestlers in assessment of structural and functional changes in skeletal muscles. Blood examination was carried out in 26 volleyball players and 25 middleweight Greco-Roman wrestlers as part of repeated comprehensive medical examination being conducted at the Department of Physical Education of Vinnytsia National Pirogov Memorial Medical University. Eligible subjects included athletes 17 to 21years of age having first adult category to master of sports and being in preparatory period of annual training macrocycle. The athletes were examined in the morning, on empty stomach, not less than 12 hours after training. The control group consisted of 25 practically healthy students having moderate physical activity. Clinical blood indices were determined by conductometric method on an automatic hematology analyzer ABX HORIBA PENTRA 60 C + (France). Hormonal studies were carried out by immunochemiluminescence method on automatic analyzer “ACCESS-2”, Bekchman Coulter (USA). Biochemical studies were performed using an automatic analyzer AU-480, Bekchman Coulter (USA). Electrolyte content was determined by ion-selective electrode technology on Medica electrolyte analyzer in EasyElectrolytes™, using lithium heparin vacuum system. Glucose levels were determined on automatic analyzer Biosen (Germany). Statistical processing was done using the program “Statistica 5.5”. Significance of differences between the variables was determined by Mann-Whitney U-test. The following serum humoral factors were found to be of great significance in assessment of structural and functional changes in skeletal muscles in volleyball players and wrestlers: the number of large immature cells of monocytes and platelets, electrolyte content, concentration of creatine phosphokinase and lactate dehydrogenase, creatinine level, as well as triglycerides and lactate levels. Establishing blood biomarkers should be an integral part of scientific and practical monitoring of health status in team athletes and wrestlers.
Influence of complex therapy with L-arginine and glutamic acid on reconstruction processes in cancer patients
Authors: Kushta A. O.
Published: July 2022

Annotation. The article presents the results of the analysis of the effect of therapeutic nutrition and its combination with a drug based on L-arginine and glutamic acid on protein metabolism and recovery processes in cancer patients. The aim of the study – development of a complex method of correction of protein metabolism with the help of therapeutic nutrition and pharmacological preparation, in order to accelerate the body's regenerative processes and regeneration. Laboratory blood data were analyzed on several indicators: total protein, albumin, urea, glucose and ketone bodies. The study was performed at the time of admission to the patient and on the 14th day after the proposed additional treatment. Statistical processing of the obtained data was performed using the mathematical statistical method on a PC using Excel software from Microsoft Office 2003, STATISTICA 5.5 according to the Student's test at p<0.05. All patients underwent surgical treatment. The results of the study show that the increase in blood protein is strongly associated not only with the use of enteral nutrition, but also with the use of metabolically active compounds based on L-arginine and glutamic acid. Thus, the use of glutamic acid and L-arginine in combination with enteral nutrition, play an important role in metabolism, which significantly improves the recovery of the general condition of cancer patients in the postoperative period, as evidenced by clinical observations and blood tests in the laboratory,
Advantages of the combined use of dexmedetomidine and magnesium sulphate in alcohol withdrawal delirium
Authors: Havrylov O. , Gomon M.
Published: July 2022

Annotation. The search for effective sedation schedule in management of alcohol withdrawal delirium, which would ensure both an adequate sedation level and sufficient safety profile, is an urgent problem of modern anesthesiology and intensive care medicine. In this respect, the aim of our study is to research the use of dexmedetomidine combined with magnesium preparations, which seems to be promising. The study was conducted on 80 patients with alcoholic delirium randomized into 4 groups, in which the following parameters were evaluated: delirium duration, plasma magnesium, hemodynamics parameters, presence of respiratory disorders, as well as the levels of urea, creatinine, transaminase, cortisol and serotonin in plasma. The control group patients underwent standard sedation therapy. In experimental group 1, standard sedation with benzodiazepines was supplemented magnesium sulfate. In group 2, we maintained infusion of dexmedetomidine. In group 3, we combined intravenous magnesium sulfas with dexmedetomidine infusion. Statistical processing was performed using: Mann-Whitney U-test, Wilcoxon T-test, and Kruskal-Wallace H-test. Duration of delirium proved to be significantly shorter in all study groups as compared to the controls, p <0.05. The best sedation therapy results were recorded in group 3, p <0.05. On the first day of treatment, all patients were found to have elevated MAP and heart rate, while significant improvement in hemodynamic parameters was observed on the third day, p <0.05. Cases of hypotension were detected in groups 1 and 2. On the third day of treatment, the patients of groups 2 and 3 showed significant improvement in plasma levels of cortisol and serotonin as compared to the controls, p<0.05, while serotonin level was higher in experimental group 3 as compared to the control patients, p<0.05. The use of combination of magnesium with dexmedetomidine infusion proved to be beneficial and effective in treatment of patients with alcohol withdrawal delirium improving the quality of patients’ care and shortening delirium duration.
Study of the effect of RS1800629 TNF polymorphism on the course of age-related macular degeneration through the prism of ANTI-VEGF therapy
Authors: Malachkova N. V. , Osama Mohammad Miteb Al-Jarrah
Published: July 2022

Annotation. Age-related macular degeneration (AMD) includes pathological changes in the deep layers of the retina, macula, and surrounding blood vessels, leading to loss of central vision. The wet form of nosology is the leading cause of irreversible blindness in developed countries among people over 60, where more than 30 million people suffer from the disease. The number of patients in the United States is expected to increase from 9.1 million in 2010 to 17.8 million in 2050. New therapeutic strategies and the development of new practical methods for identifying patients at high risk of treatment resistance are needed to reduce the prevalence of the disease. That is why the aim of the study was to shed light on the role of the rs1800629 polymorphism of the TNF gene as one of the prognostic factors in the effectiveness of treatment of the wet form of AMD. The study group consisted of 162 people diagnosed with a wet form of pathology, while the comparison group consisted of 105 people without a history of ophthalmic pathology. Optical coherence tomography of certain areas of the eye, including the retina, was used to confirm or rule out the diagnosis. To detect the polymorphism status of the TNF gene, the real-time polymerase chain reaction method was used on the BioRad CFX 96 thermocycler-amplifier, using “Litekh” (RF) reagent kits. Statistical processing of the results was performed by determining the Hardy-Weinberg equilibrium, Student’s and Wilcoxon’s criteria, logistic regression using OR values and 95% CI, and by subtracting RR and χ². The study found that the frequency of genotype distribution with mutant allele A was predominant among patients in the study group, and the G allele was determined predominantly in the control group and was associated with better results of anti-VEGF therapy. The results of OCT confirmed this information, because among carriers of genotypes GG and GA (p<0.05) visual acuity improved even after the first injection of the drug in most areas, while among carriers of homozygous genotype AA was not sufficient probability of biological effects, efficiency in the presence of this genotype was reduced (p<0,05). The results of treatment were most representative in the areas of OCT 4, OCT 8 and macula (OCT 3) – among carriers of allele A in the OCT 4 zone, the chance of resistance to treatment was 3.1 times (OR=3.1; 95% SI 1,686 - 5.7) higher than in carriers of the G allele, and in the zone of OCT 8 in patients from the study group the risk of ineffectiveness of therapy was 2.81 times (OR=2.81; 95% CI 1.56 - 5.059) higher than in the corresponding zone of the G allele carriers. This suggests a lack of clinical efficacy in individuals carrying the mutant A allele, and the need to identify the status of polymorphisms for prognostic assessment of treatment efficacy.
Stopping bleeding from neck injuries in the first stage in military conditions
Authors: Strezhak V. V.
Published: July 2022

Annotation. Damage to blood vessels in the neck, which is accompanied by massive bleeding, occurs both in peacetime in ENT oncology practice and as a result of trauma during hostilities. The chances of survival depend on the time of onset of medical care and the methods used to fix the neck. The aim of the work is to consider ways to help with neck injuries, identify their shortcomings and publish the developed method of stopping bleeding in the neck in the first stage in the ENT oncology hospital, pointing out its advantages. The experience is based on the application of the proposed method in 20 men with laryngeal and pharyngeal cancer with regional metastases in the lymph nodes of the neck. The proposed procedure for self-care after a neck injury is to turn and tilt the head toward the wound and open the mouth to clamp and slow or stop the bleeding; if you need to increase the pressure on the wound in this position of the head, it is recommended to insert a tampon with hemostatic material. The proposed successful experience of stopping bleeding from the main vessels of the neck in the oncology department can be used for neck injuries in combat conditions in the first stage of medical care.
Evaluation of the effectiveness of the gastroduodenitis prevention program in patients of retirement age with essential arterial hypertension who participated in the “Affordable Medicines” program according to the IECR
Authors: Ocheredko O. M. , Rudenko A. A.
Published: July 2022

Annotation. Initiated in 2017 by the Government of Ukraine, the “Affordable Medicines” program has undoubtedly become a significant support for the population of Ukraine, however, access to free treatment has often been the reason for taking too high doses of drugs, overdue drugs, etc. This fact was the impetus for us to conduct a study that would help solve the problems that arose during the implementation of the Government program “Affordable Medicines”. A combined (retrospective, prospective) study was conducted in which 150 patients of retirement age took part. Patients were divided into 2 groups. The case group included 100 patients with essential arterial hypertension and gastroduodenitis. The control group consisted of 50 patients with essential arterial hypertension without gastroduodenitis. During the work on the study, attention was focused on the peculiarities of gastroduodenitis in patients taking drugs for the treatment of cardiovascular diseases using the program "Affordable Medicines". Information on the costs of treatment and prevention of essential arterial hypertension and gastroduodenitis is also collected. During the work, the following research methods were used: system approach and system analysis, statistical, epidemiological, sociological, method of statistical modeling according to MCMC algorithms, expert assessments, survival curves. As a result of the study, a gastroduodenitis prevention program was proposed for patients of retirement age with essential arterial hypertension who receive treatment under the Affordable Medicines program. A balance model for assessing the medical and economic efficiency of the proposed prevention program has been developed. The assessment of the medical and economic efficiency of the proposed prevention program according to the developed balance model of evaluation was carried out.
Difficulties in diagnosis of alcoholic fatty liver disease and metabolically associated fatty liver disease
Authors: Pivtorak K. V. , Yakovleva O. O. , Pashinskyi Y. M. , Mazur G. M. , Masloyid T. M.
Published: July 2022

Annotation. According to many researchers, non-alcoholic fatty liver disease as an independent disease is underestimated by a large percentage of both patients and physicians. Asymptomatic course, lack of specific complaints leads to the fact that non-alcoholic fatty liver disease is detected by chance on the basis of the detected increase in transaminases or hepatomegaly, which is detected during examination for other pathologies. The high prevalence of the disease, as well as the increase in cardiovascular risk and the risk of hepatocellular carcinoma in non-alcoholic fatty liver disease requires the search for simple and reliable methods of detecting this pathology. We searched for studies that study the diagnostic accuracy of various methods for diagnosing nonalcoholic fatty liver disease and differentiated approaches to their use in scientometric databases PubMED/MEDLINE, EMBASE and the Cochrane Library. The use of the gold standard of diagnosis, namely, liver biopsy is limited by its invasive nature and high cost. The new concept of metabolically associated liver disease and the criteria for its diagnosis allow clinicians to identify more patients at risk of adverse outcomes in clinical practice. The most common and minimally sufficient is the ultrasound examination of the liver with elastography, which allows to assess both the indicators of steatosis and the degree of fibrosis. The diagnostic scales FLI, NAFLD liver fat score, NAFLD liver fibrosis score, APRI, FIB4 and fibromax test remain relevant for the diagnosis of fatty liver disease. Anthropometric diagnostic tests for screening diagnosis of non-alcoholic fatty liver disease are still relevant. Research is currently being conducted to study the epidemiology and mechanisms of development, which will reveal epidemiological and pathogenetic differences between metabolic associated fatty liver disease and non-alcoholic fatty liver disease, which will serve as a step towards the introduction of new diagnostic, prognostic and therapeutic measures.
Liver resection as a stimulation of its regeneration in chronic diseases
Authors: Sydorenko B. V. , Pivtorak K. V. , Monastyrskiy V. M.
Published: July 2022

Annotation. Uncertainty of measures for the treatment of liver cirrhosis and hepatocellular carcinoma necessitates the development of new treatments for patients. The analysis of the specialized scientific literature for generalization of the given mechanisms of regeneration of a liver at chronic liver diseases and use in clinical practice of modern medical actions is carried out. The search of specialized scientific literature for the period from 2012 to 2022 to identify problematic issues of liver regeneration after different volumes of its resection in chronic liver disease and the disclosure of mechanisms that inhibit or directly stimulate liver regeneration. It has been established that the liver has sufficient regenerative potential, capable of regeneration after 75% removal of its volume in humans and up to 90% in some models of rodents, which allows it to withstand various types of damage, including physical injuries, infections, inflammation, direct toxicity and immunological disorders. Liver regeneration after resection is achieved in different ways depending on the size of the liver resection. Regeneration after resection of a third of the liver is achieved mainly by hypertrophy with a small number of cell divisions. Resection of 70% of the liver volume is accompanied by regeneration in the form of hyperplasia due to hepatocyte proliferation. Increased hepatocyte growth factor in sinusoidal endothelial cells of the liver stimulates liver regeneration. Regression of fibrosis is possible due to the elimination of pathophysiological causes, as well as the elimination of activated myofibroblasts, which leads to the resorption of scar tissue. In the future, it is advisable to investigate and test in practice innovative technologies to stimulate liver regeneration in non-alcoholic fatty liver disease.
Sofroniy Terentiyovych Novytsky – Head of the Department of Operative Surgery and Topographic Anatomy of Vinnytsia State Medical Institute (1937-1941)
Authors: Kokus V. V.
Published: July 2022

Annotation. The article, based on the analysis of literary and archival sources, highlights the life, scientific, pedagogical and medical activities of the famous surgeon and anatomist S.T. Novitsky, analysed his scientific heritage, revealed the content of major scientific works of the scientist.
Improvement of Neo-Confucianism of Seoin through Kim Jang-Saeng's Geunsarok Seokeui
Authors:   THE  TAEDONG  CENTER  FOR  EASTERN  CLASSICS, KANG Min-woo
Published: July 2022

This study is aimed at exploring compilation process of annotation for Chin-ssu Lu (近思錄) of Kim Jang-saeng (金長生, 1548-1631) and its importance in the history of thoughts. Zhu Xi (朱熹, 1130-1200) and Lu Zuqian (呂祖謙, 1137- 1181) wrote Chin-ssu Lu for the beginners' learning. It took great part in beginner's learning with Xiaoxue (小學) that provides fundamental guideline in action. In spite of its recognized importance, Chin-ssu Lu did not receive attention from intellectuals of the time, while Xiaoxue received constant attention after emphasis on practice of Kim Jong-Jik (金宗直, 1431-1492). Chin-ssu Lu was re-examined by Yi Hwang (李滉, 1502-1571) of the 16th century. Studying Four Books and Five Classics, Yi Hwang provided a groundwork for translation of Confucian textbooks with studying Chin-ssu Lu in his later years. But he could not finish his work. Most annotations of beginner's learning based on Zhu Xi's studies (朱子學) was organized by Seoin (西人). Kim Jang-saeng compiled the annotations of Chin-ssu Lu for the first time by writing Geunsarok Seokeui (近思錄釋疑). Unlike previous annotations, Geunsarok Seokeui contained various theories of intellectuals of Joseon and these theories took greater part than theories of Chinese intellectuals based on Zhu Xi's other writings due to Joseon's cumulated former studies about the annotations. As study of Four books and Five Classics proceeded in Joseon, independent perspectives to understand Zhu Xi's studies were born. In this trend, Kim Jang-saeng compiled these studies and made a basis for study about Chin-ssu Lu. In the process, Kim Jang-saeng supplemented Yi Yi's position in the controversy over Neo-Confucianism that continued from Yi Hwang and created a foundation for maintaining the school.
RELATIONSHIP AMONG WORK CONTRACT SATISFACTION, JOB SATISFACTION, AND PRODUCTIVITY: AN ANALYSIS IN HOTEL INDUSTRY IN CROATIA
Authors:   Faculty of Tourism and Hospitality Management, University of Rijeka, Primorska 42, Naselje Ika, 51410 Opatija, Croatia, Pupavac Justin , Pupavac Drago ,   Polytechnic of Rijeka, Vukovarska 58, 51000 Rijeka, Croatia, Marinac Antun ,   Polytechnic of Požega, Vukovarska 17, 34000 Požega, Croatia
Published: July 2022

In the last couple of decades, non-standard forms of work contracts increase. Usually, non-standard work contracts are connected with higher job insecurity and lower level of job satisfaction which can lead to lower productivity. In accordance with that, the main aim of this research is to explore the correlation between job satisfaction, productivity, and satisfaction with a work contract in the hotel industry in Croatia. The research results are based on the primary data collected by the survey carried out in the hotel industry in Croatia during the summer season of 2018. An ANOVA test is used to achieve the objective and the purpose of the study and to test the set hypotheses. The main finding of this paper points to the conclusion that employees who achieve high productivity show greater satisfaction with the work contract and greater job satisfaction in all dimensions. The obtaining results in this scientific debate can be helpful for hotel managers for enhancing labor productivity.
Mobile instant messaging techno-stressors: Measurement, dimensionality, and relationships with type of usage
Authors: Ardèvol-Abreu Alberto , Rodríguez-Wangüemert Carmen , Delponti Patricia
Published: July 2022

Increasingly popular mobile instant messaging (MIM) apps allow users to interact anytime and anywhere with different purposes, such as coordinating work-related issues, staying in touch with people they love, or passing the time. But recent research suggests that MIM may create excessive demands on people and become a source of technostress. For example, users may experience communication overload, invasion of their face-to-face activities, pressure to respond to messages with urgency, or ambiguity regarding the intention or tone of their interactions. Building on these ideas, we develop a specific, multidimensional measure of MIM technostress and explore how it relates to different uses. To do so, we use survey data from a diverse sample of 1,259 residents in Spain. Exploratory and confirmatory factor analyses conducted on different halves of the sample supported a four-dimensional, second-level construct of MIM stress. Furthermore, structural equation model results suggest that not all uses are equally associated with MIM stress. Relatedness and intimacy uses were not positively related to MIM stress or any of its dimensions. Conversely, work uses, coordination of social activity, and even passing the time were positively associated with all techno-stressors. We discuss our findings with an eye toward promoting healthy use of MIM apps.
ACTUALIZATION OF THE DEVELOPMENT OF PROFESSIONAL COMPETENCIES AND PERSONAL QUALITIES OF THE PRESCHOOL EDUCATIONAL INSTITUTION METHODOLOGIST
Authors: Skrypnyk Nelya
Published: July 2022

The article explores one of the important aspects of the problem of forming the managerial competence of the head of an educational institution. The aim of the work was to update the professional and personal characteristics of one of the heads of a preschool education institution as an educator-methodologist.The author describes the basic requirements for professional competencies and specific personal qualities of an educator-methodologist. The specifics of professional competence of an educator-methodologist are substantiated as a dynamic combination of general and special personal-professional characteristics that reflect gnostic, correctional-gnostic, constructive, communicative, organizational, and research skills necessary for effective implementation of methodological tasks of preschool education in modern challenges. In addition, the author clarifies and characterizes the personal mobility of the educator-methodologist as one of the key professional characteristics and defines its criteria. An analysis of the personal qualities and abilities of the educator-methodologist, which are not purely professional, but are necessary for the successful management of the educational process in the preschool institution. The conclusions note that the combination of high professionalism and development of relevant personal qualities and abilities of the educator-methodologist, in general, represents a modern, dynamic, creative, and competitive manager of the new generation of educational process in preschool education. The presented study is incomplete. In the future, it is planned to develop modern forms, methods, and technologies for preparing the future manager to perform the duties and functions of an educator-methodologist in a preschool institution.

Keywords: methodologist; preschool education; professional competence; conditions; tasks; innovations; reforms; mobility; modernization; functions of a preschool education methodologist.
TRANSFORMATION PROCESSES IN THE EDUCATION OF UKRAINE: CHANGES IN THE LEGISLATION ON THE APPLICATION OF THE CONCEPT OF "INFRINGEMENT OF INTELLECTUAL DEVELOPMENT"
Authors: Kryvorotko Anastasiia
Published: July 2022

Until recently, intellectual disturbances were defined by terms such as oligophrenia, imbecility, debauchery, mental retardation, but due to the negative color of these terms and the orientation towards such universal values as respect for the dignity of each person, the protection of constitutional rights and freedoms, tolerance and humanism, they have been abandoned. Ukraine draws attention to the fact that all primarily people, as individuals, and then their disorders in development.In the article, we analyzed the understanding of “mental retardation” in the 21st century on the basis of the normative legal documents of Ukraine, namely, laws, regulations and orders regulating the education of people with special educational needs. Found that the concept of “mental retardation” has become widespread since 1988, and since 2015 began to change in such changes as intellectual disabilities, mental disorder (2016), intellectual disturbances (from 2017 to the present). Traced the vicariously understanding “mental retardation” by modern Ukrainian scholars. Illustrate by scholars on the history of the concept of “mental retardation”. Determined that theunderstood “mental retardation” was replaced by “intellectual disability”. Determined that the change in the term “mental retardation” in Ukraine was affected by the change in terminology in the Convention on the Rights of Persons with Disabilities. Changes in the names of degrees of mental retardation are highlighted.Prospects for further research are considered the consideration of the regulatory framework of Ukraine for the education of children with intellectual disabilities.

Keywords: education; special education; legislation; humanism; people with special educational needs; intellectual disabilities; ICF; ICD-11.
PECULIARITIES OF USING INTERNET EDUCATION IN THE TRAINING OF ENGLISH LANGUAGE TEACHERS
Authors: Kudelska Olha , Melnytska Olena
Published: July 2022

Due to a drastic transition to a remote form of organization of the educational process, the demand for Internet products aimed at education has increased. Based on this, online services offer newer platforms and resources for online learning and foreign language studying in particular. In order to ensure the appropriate quality of the educational process, a modern teacher must be free to operate the tools of smart technologies. The purpose of this article is to reveal the concept of online education and study the features of the use of elements of this format of education in the training of English teachers. To achieve this goal, the following research methods were used: analysis of the work of domestic and foreign scientists on the research issue, synthesis, and generalization. The article offers an overview of the latest online educational platforms and applications for learning foreign languages with the possibility of integration into vocational training courses for students of higher education institutions in the specialty 014 Secondary Education (Language and Literature (English)). The paper pays special attention to the use of Internet resources that promote the development of critical thinking, speaking skills, skills of organizing autonomous learning, and the ability of users to assess themselves and monitor their learning progress. The benefits of using online education in the training of future English teachers were identified. We can state that the variety of online resources and platforms for learning foreign languages provides teachers with effective tools for the development of students’ mastery of the material under the study.

Keywords: Internet education; innovative educational technologies; British Council; the English language; online learning; educational platforms; teacher training; English language teacher; distance learning.