bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Movie 1 from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Authors: Ghosh Susmita , Varela Lidenys , Sood Akshay , Park Ben Ho , Lotan Tamara L.
Published: March 2023

MOV - 6269 KB, Growth factor-induced epithelial budding and invasion of ECM in mammary organoid system. 100-hour time-lapse DIC imaging (days 3-7 after addition of growth factor) of FGF2-induced epithelial budding in a wild-type mammary organoid. Luminal epithelial buds invade beyond the myoepithelial layer and into surrounding Matrigel, recapitulating normal ductal morphogenesis and the early stages of invasive breast cancer.
Figure S3 from Synergy between the NAMPT Inhibitor GMX1777(8) and Pemetrexed in Non–Small Cell Lung Cancer Cells Is Mediated by PARP Activation and Enhanced NAD Consumption
Authors: Chan Manuel , Gravel Michel , Bramoullé Alexandre , Bridon Gaëlle , Avizonis Daina , Shore Gordon C. , Roulston Anne
Published: March 2023

Figure S3. Cell viability of PTX, GMX and PTX-GMX combo is affected by exogenous NMN and folic acid.
Supplementary Figure 3 from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Authors: Ghosh Susmita , Varela Lidenys , Sood Akshay , Park Ben Ho , Lotan Tamara L.
Published: March 2023

PDF - 4128 KB, Increased epithelial budding in mTORC1-inhibited PTEN-/- organoids is not due to increased net cell proliferation.
Supplementary Figure 2 from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Authors: Ghosh Susmita , Varela Lidenys , Sood Akshay , Park Ben Ho , Lotan Tamara L.
Published: March 2023

PDF - 915 KB, Short-term PTEN loss induces independence from endogenous HER signaling in mammary organoids.
Supplementary Tables 1 - 4 from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism
Authors: Grassian Alexandra R. , Parker Seth J. , Davidson Shawn M. , Divakaruni Ajit S. , Green Courtney R. , Zhang Xiamei , Slocum Kelly L. , Pu Minying , Lin Fallon , Vickers Chad , Joud-Caldwell Carol , Chung Franklin , Yin Hong , Handly Erika D. , Straub Christopher , Growney Joseph D. , Vander Heiden Matthew G. , Murphy Anne N. , Pagliarini Raymond , Metallo Christian M.
Published: March 2023

PDF file - 93KB, Estimates Fluxes for HCT116 Parental and IDH1 R132H/+ 2H1 cells under Normoxia and Hypoxia (2 percent Oxygen).
Supplementary Methods, Figure Legends from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism
Authors: Grassian Alexandra R. , Parker Seth J. , Davidson Shawn M. , Divakaruni Ajit S. , Green Courtney R. , Zhang Xiamei , Slocum Kelly L. , Pu Minying , Lin Fallon , Vickers Chad , Joud-Caldwell Carol , Chung Franklin , Yin Hong , Handly Erika D. , Straub Christopher , Growney Joseph D. , Vander Heiden Matthew G. , Murphy Anne N. , Pagliarini Raymond , Metallo Christian M.
Published: March 2023

PDF file - 136KB
Supplementary Table 2 from JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells
Authors: Kroon Paula , Berry Paul A. , Stower Michael J. , Rodrigues Greta , Mann Vincent M. , Simms Matthew , Bhasin Deepak , Chettiar Somsundaram , Li Chenglong , Li Pui-Kai , Maitland Norman J. , Collins Anne T.
Published: March 2023

PDF file, 84K, 4.IL-6 levels (pg/ml/103 cells) in the supernatant of prostatic primary cultures.
Data Supplement from miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors
Authors: Gong Chang , Nie Yan , Qu Shaohua , Liao Jian-You , Cui Xiuying , Yao Herui , Zeng Yunjie , Su Fengxi , Song Erwei , Liu Qiang
Published: March 2023

Supplementary Figure S3. miR-21 induces myofibroblast differentiation, proliferation and invasion of the stromal cells in PTs.
Supplemental Fig. 8 from Pancreatic Cancer–Specific Cell Death Induced In Vivo by Cytoplasmic-Delivered Polyinosine–Polycytidylic Acid
Authors: Bhoopathi Praveen , Quinn Bridget A. , Gui Qin , Shen Xue-Ning , Grossman Steven R. , Das Swadesh K. , Sarkar Devanand , Fisher Paul B. , Emdad Luni
Published: March 2023

Supplemental Fig. 8. In vivo cytoplasmic delivery of [pIC] using invivo jetPEI induces apoptosis in pancreatic tumors
Data Supplement from miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors
Authors: Gong Chang , Nie Yan , Qu Shaohua , Liao Jian-You , Cui Xiuying , Yao Herui , Zeng Yunjie , Su Fengxi , Song Erwei , Liu Qiang
Published: March 2023

Supplementary Figure S6. miR-21 induces myofibroblasts differentiation in breast PTs xenografts.
Supplemental Fig. 5 from Pancreatic Cancer–Specific Cell Death Induced In Vivo by Cytoplasmic-Delivered Polyinosine–Polycytidylic Acid
Authors: Bhoopathi Praveen , Quinn Bridget A. , Gui Qin , Shen Xue-Ning , Grossman Steven R. , Das Swadesh K. , Sarkar Devanand , Fisher Paul B. , Emdad Luni
Published: March 2023

Supplemental Fig. 5. Effect of expression of XIAP alone, survivin alone and the combination on [pIC]PEI-induced apoptosis
Supplemental Fig. 3 from Pancreatic Cancer–Specific Cell Death Induced In Vivo by Cytoplasmic-Delivered Polyinosine–Polycytidylic Acid
Authors: Bhoopathi Praveen , Quinn Bridget A. , Gui Qin , Shen Xue-Ning , Grossman Steven R. , Das Swadesh K. , Sarkar Devanand , Fisher Paul B. , Emdad Luni
Published: March 2023

Supplemental Fig. 3. [pIC]PEI does not change XIAP and survivin at the mRNA level
Supplemental Tables S1-S2 from Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake
Authors: Alvarez James V. , Belka George K. , Pan Tien-Chi , Chen Chien-Chung , Blankemeyer Eric , Alavi Abass , Karp Joel S. , Chodosh Lewis A.
Published: March 2023

Supplemental Tables S1-S2. Multivariate analysis testing the independence of variables in predicting FDG uptake (S1); Final multivariate model with the best balance between predictive power for FDG uptake and model complexity (S2).
Supplemental Figure S1 from Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake
Authors: Alvarez James V. , Belka George K. , Pan Tien-Chi , Chen Chien-Chung , Blankemeyer Eric , Alavi Abass , Karp Joel S. , Chodosh Lewis A.
Published: March 2023

Supplemental Figure S1. Variable decrease in FDG uptake following Ras de-induction.
Supplementary Figure S5 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: March 2023

Supplementary Figure S5. Archazolid induces ferritin, transferrin and RRM2 mRNA levels.
Supplementary Figure 5 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: March 2023

ÃŽÂ²III-tubulin shRNA NSCLC cells show increased maspin expression.
Supplementary Figure 4 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: March 2023

Validation of proteins found to be differentially expressed in H460 ÃŽÂ²III-tubulin shRNA expressing cells.
Supplementary Figure 3 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: March 2023

Two-Dimensional Difference Gel Electrophoresis (2D-DIGE) of cytoplasmic and nuclear extracts of H460 NSCLC cells expressing ÃŽÂ²III-tubulin or control shRNA.
Supplementary Table S5 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Table S5. Genes for which a positive correlation was found between copy number variation and gene expression are listed.
Supplementary Table S4 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Table S4. Variant allele frequencies are listed for each sequence variation detected.
Supplemental Figure Legends from Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia
Authors: Patrussi Laura , Capitani Nagaja , Martini Veronica , Pizzi Marco , Trimarco Valentina , Frezzato Federica , Marino Filippo , Semenzato Gianpietro , Trentin Livio , Baldari Cosima T.
Published: March 2023

Supplemental Figure Legends from Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia
Supplementary Table S1 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Table S1. Model Systems used in this study.
Supplementary material from Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue
Authors: Kennedy Brendan F. , McLaughlin Robert A. , Kennedy Kelsey M. , Chin Lixin , Wijesinghe Philip , Curatolo Andrea , Tien Alan , Ronald Maxine , Latham Bruce , Saunders Christobel M. , Sampson David D.
Published: March 2023

Mechanisms of tissue deformation in OCME
Supplemental Methods from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Methods. Description of additional methods and procedures used in the study.
Supplemental Figure S8 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Figure S8. Analyses of HDAC biomarkers in tumor xenografts in mice treated with 1A12.
Supplemental Figure S6 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Figure S6. Specificity of 1A12 in inhibition of HDAC6.
Supplementary Figure S1 from Definition of Prostaglandin E2–EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth
Authors: Ma Xiaojun , Aoki Tomohiro , Tsuruyama Tatsuaki , Narumiya Shuh
Published: March 2023

Supplementary Figure S1. Colon tumorigenesis in PG receptor-deficient mice and the effect of Ptger2-deficiency on cancer progression.
Supplemental Figure S1 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Figure S1. Effect of HDAC and Hsp90 inhibitors on Hsp90 (α/β)/p23 interactions.
Supplemental video 2 from ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy
Authors: Messai Yosra , Noman Muhammad Zaeem , Hasmim Meriem , Janji Bassam , Tittarelli Andrés , Boutet Marie , Baud Véronique , Viry Elodie , Billot Katy , Nanbakhsh Arash , Ben Safta Thouraya , Richon Catherine , Ferlicot Sophie , Donnadieu Emmanuel , Couve Sophie , Gardie Betty , Orlanducci Florence , Albiges Laurence , Thiery Jerome , Olive Daniel , Escudier Bernard , Chouaib Salem
Published: March 2023

Supplemental video 2. 786-0 cells described in Figure 3B were recorded by time-lapse video microscopy
Supplementary Methods from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

Supplementary Methods
Supplementary Table S3 from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: March 2023

Supplementary Table S3. Dasatinib-regulated pY-peptides identified from both cell lines (n=73).
Supplementary Figure S1 from Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay–Independent Manner
Authors: Kratochvill Franz , Gratz Nina , Qualls Joseph E. , Van De Velde Lee-Ann , Chi Hongbo , Kovarik Pavel , Murray Peter J.
Published: March 2023

Representative Flow Cytometry plots for the detection of cytokine positive CD11b+ TAMs from WT and p38aÎ”H mice as analyzed in Fig. 6C.
Supplementary Figure S6 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: March 2023

Supplementary Figure S6. Foretinib and MET knockdown inhibits proliferation, migration and invasion of medulloblastoma cells
Supplementary Materials and Methods from Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells
Authors: Ahmed Shafiq U. , Carruthers Ross , Gilmour Lesley , Yildirim Salih , Watts Colin , Chalmers Anthony J.
Published: March 2023

Supplementary Materials and Methods
Supplementary Figure S2 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: March 2023

Supplementary Figure S2. Biological pathways and processes associated with high cMET and low cMET SHH medulloblastomas
Supplementary Methods and References from CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus
Authors: Koh Siang-Boon , Courtin Aurélie , Boyce Richard J. , Boyle Robert G. , Richards Frances M. , Jodrell Duncan I.
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Methods from Effective Cancer Vaccine Platform Based on Attenuated Salmonella and a Type III Secretion System
Authors: Xu Xin , Hegazy Wael A.H. , Guo Linjie , Gao Xiuhua , Courtney Amy N. , Kurbanov Suhrab , Liu Daofeng , Tian Gengwen , Manuel Edwin R. , Diamond Don J. , Hensel Michael , Metelitsa Leonid S.
Published: March 2023

Supplemental Methods
supplementary figure 4 from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: March 2023

supplementary figure 4: the in-vivo engraftment of primary leukemia cells after co-culture on normal or AML-derived MSCs.
Supplementary Materials and methods from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
Authors: Mumblat Yelena , Kessler Ofra , Ilan Neta , Neufeld Gera
Published: March 2023

Supplementary Materials and methods. Contains the description of materials and methods used in the experiments shown in the supplementary figures and additional details for some of the methods and reagents used in the main manuscript which could not be described in sufficient detail in the main manuscript due to constraints of length.
Supplementary Figure S6 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Authors: Mudduluru Giridhar , Abba Mohammed , Batliner Jasmin , Patil Nitin , Scharp Maike , Lunavat Taral R. , Leupold Jörg Hendrik , Oleksiuk Olga , Juraeva Dilafruz , Thiele Wilko , Rothley Melanie , Benner Axel , Ben-Neriah Yinon , Sleeman Jonathan , Allgayer Heike
Published: March 2023

Supplementary Figure S6. Independent in vivo validation of the novel miRNA-network in brain tumors in the Oncomine database.
Supplementary Figures 1 - 3 from Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2
Authors: Tanizaki Junko , Ercan Dalia , Capelletti Marzia , Dodge Michael , Xu Chunxiao , Bahcall Magda , Tricker Erin M. , Butaney Mohit , Calles Antonio , Sholl Lynette M. , Hammerman Peter S. , Oxnard Geoffrey R. , Wong Kwok-Kin , Jänne Pasi A.
Published: March 2023

Supplemental Figure 1. Immunohistochemical analyses of tumors from NSCLC patient with FGFR2 A266_S267ins for H&E (hematoxylin and eosin) (A), and CD56 (B). Supplemental Figure 2. The signal inhibitory effect of ponatinib in cells expressing FGFR2 A266_S267ins, FGFR2 290_291WI>C or FGFR2-TACC3. Supplemental figure 3. The effect of FGF stimulation in NIH-3T3 cells with FGFR2 wild type and those with FGFR2 A266_S267ins.
Supplemental Table S1 from Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2
Authors: Tanizaki Junko , Ercan Dalia , Capelletti Marzia , Dodge Michael , Xu Chunxiao , Bahcall Magda , Tricker Erin M. , Butaney Mohit , Calles Antonio , Sholl Lynette M. , Hammerman Peter S. , Oxnard Geoffrey R. , Wong Kwok-Kin , Jänne Pasi A.
Published: March 2023

Table S1. Summary of FGFR2 mutations.
Supplementary Figure S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Authors: Mudduluru Giridhar , Abba Mohammed , Batliner Jasmin , Patil Nitin , Scharp Maike , Lunavat Taral R. , Leupold Jörg Hendrik , Oleksiuk Olga , Juraeva Dilafruz , Thiele Wilko , Rothley Melanie , Benner Axel , Ben-Neriah Yinon , Sleeman Jonathan , Allgayer Heike
Published: March 2023

Supplementary Figure S2. Role of miR-218 investigated in additional cancer entities.
Supplemental Table S1 from Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer
Authors: Wijdeven Ruud H. , Pang Baoxu , van der Zanden Sabina Y. , Qiao Xiaohang , Blomen Vincent , Hoogstraat Marlous , Lips Esther H. , Janssen Lennert , Wessels Lodewyk , Brummelkamp Thijn R. , Neefjes Jacques
Published: March 2023

Table S1: Overview of all screening hits.
Supplemental Figures 1 - 4 from Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer
Authors: Wijdeven Ruud H. , Pang Baoxu , van der Zanden Sabina Y. , Qiao Xiaohang , Blomen Vincent , Hoogstraat Marlous , Lips Esther H. , Janssen Lennert , Wessels Lodewyk , Brummelkamp Thijn R. , Neefjes Jacques
Published: March 2023

Figure S1: Keap1, SMARCB1, SMARCA4 and ARID1A regulate resistance to doxorubicin. Figure S2: Keap1 controls expression of NQO1 through Nrf2. Figure S3: C9orf82 regulates DNA double strand break repair. Figure S4: Expression of SWI/SNF complex subunits correlates to clinical outcome.
Supplemental Table 3 from Distinct Luminal-Type Mammary Carcinomas Arise from Orthotopic Trp53-Null Mammary Transplantation of Juvenile versus Adult Mice
Authors: Nguyen David H. , Ouyang Haoxu , Mao Jian-Hua , Hlatky Lynn , Barcellos-Hoff Mary Helen
Published: March 2023

Human orthologs of JvA 243 profile. Proliferation-related genes removed.
Supplemental Table 1 from Distinct Luminal-Type Mammary Carcinomas Arise from Orthotopic Trp53-Null Mammary Transplantation of Juvenile versus Adult Mice
Authors: Nguyen David H. , Ouyang Haoxu , Mao Jian-Hua , Hlatky Lynn , Barcellos-Hoff Mary Helen
Published: March 2023

Histopathology and features of JH and AH tumors.
Supplementary Figure Legend from Evidence Suggesting That Discontinuous Dosing of ALK Kinase Inhibitors May Prolong Control of ALK+ Tumors
Authors: Amin Amit Dipak , Rajan Soumya S. , Liang Winnie S. , Pongtornpipat Praechompoo , Groysman Matthew J. , Tapia Edgar O. , Peters Tara L. , Cuyugan Lori , Adkins Jonathan , Rimsza Lisa M. , Lussier Yves A. , Puvvada Soham D. , Schatz Jonathan H.
Published: March 2023

Supplementary Figure Legend. Legend for Supplementary Figures S1-S5.
Supplementary Figure 5 from Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer
Authors: Takeuchi Shintaro , Baghdadi Muhammad , Tsuchikawa Takahiro , Wada Haruka , Nakamura Toru , Abe Hirotake , Nakanishi Sayaka , Usui Yuu , Higuchi Kohtaro , Takahashi Mizuna , Inoko Kazuho , Sato Syoki , Takano Hironobu , Shichinohe Toshiaki , Seino Ken-ichiro , Hirano Satoshi
Published: March 2023

No significant difference in the frequencies of CD68+ macrophages in cancer patients after treatment with pre-operative chemotherapy.
Supplementary Figure 2 from Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer
Authors: Takeuchi Shintaro , Baghdadi Muhammad , Tsuchikawa Takahiro , Wada Haruka , Nakamura Toru , Abe Hirotake , Nakanishi Sayaka , Usui Yuu , Higuchi Kohtaro , Takahashi Mizuna , Inoko Kazuho , Sato Syoki , Takano Hironobu , Shichinohe Toshiaki , Seino Ken-ichiro , Hirano Satoshi
Published: March 2023

Gemcitabine amplifies the expression of multiple MDSCs-inducing cytokines including GM-CSF in PANC-1 cell line.
Supplemental Figure Legends from Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer
Authors: Takeuchi Shintaro , Baghdadi Muhammad , Tsuchikawa Takahiro , Wada Haruka , Nakamura Toru , Abe Hirotake , Nakanishi Sayaka , Usui Yuu , Higuchi Kohtaro , Takahashi Mizuna , Inoko Kazuho , Sato Syoki , Takano Hironobu , Shichinohe Toshiaki , Seino Ken-ichiro , Hirano Satoshi
Published: March 2023

Supplemental Figure Legends
Supplementary Figure Legends from α-Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration
Authors: Boggs Amanda E. , Vitolo Michele I. , Whipple Rebecca A. , Charpentier Monica S. , Goloubeva Olga G. , Ioffe Olga B. , Tuttle Kimberly C. , Slovic Jana , Lu Yiling , Mills Gordon B. , Martin Stuart S.
Published: March 2023

Supplementary Figure Legends.
Supplementary Figure Legends from Novel Cell-Penetrating Peptide-Based Vaccine Induces Robust CD4+ and CD8+ T Cell–Mediated Antitumor Immunity
Authors: Derouazi Madiha , Di Berardino-Besson Wilma , Belnoue Elodie , Hoepner Sabine , Walther Romy , Benkhoucha Mahdia , Teta Patrick , Dufour Yannick , Yacoub Maroun Céline , Salazar Andres M. , Martinvalet Denis , Dietrich Pierre-Yves , Walker Paul R.
Published: March 2023

Legend for Supplementary Figures S1-S7.
Supplemental Figure S3 from Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer
Authors: Du Juan , Cieslak John A. , Welsh Jessemae L. , Sibenaller Zita A. , Allen Bryan G. , Wagner Brett A. , Kalen Amanda L. , Doskey Claire M. , Strother Robert K. , Button Anna M. , Mott Sarah L. , Smith Brian , Tsai Susan , Mezhir James , Goswami Prabhat C. , Spitz Douglas R. , Buettner Garry R. , Cullen Joseph J.
Published: March 2023

Supplemental Figure S3. Ascorbate radiosensitization induces formation of γ-H2AX.
Supplemental Tables S1 and S2 from Breast Cancer Cells Respond Differentially to Modulation of TGFβ2 Signaling after Exposure to Chemotherapy or Hypoxia
Authors: O'Brien Siobhan K. , Chen Liang , Zhong Wenyan , Armellino Douglas , Yu Jiyang , Loreth Christine , Follettie Maximillian , Damelin Marc
Published: March 2023

Supplemental Tables S1 and S2. Table S1: CD44hi cells that survived epirubicin exhibited broader enrichment (relative to CD44hi cells that survived hypoxia) for signatures related to stem cells, EMT, metastasis, Wnt signaling, cancer progression, and oncogenic signaling. Table S2: CD44hi cells that survived epirubicin were associated with substantially more Master Regulators, including transcription factors and upstream signaling factors, than CD44hi cells that survived hypoxia.
Supplementary Figures S1-S6 from Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models
Authors: Eberlein Catherine A. , Stetson Daniel , Markovets Aleksandra A. , Al-Kadhimi Katherine J. , Lai Zhongwu , Fisher Paul R. , Meador Catherine B. , Spitzler Paula , Ichihara Eiki , Ross Sarah J. , Ahdesmaki Miika J. , Ahmed Ambar , Ratcliffe Laura E. , O'Brien Elizabeth L. Christey , Barnes Claire H. , Brown Henry , Smith Paul D. , Dry Jonathan R. , Beran Garry , Thress Kenneth S. , Dougherty Brian , Pao William , Cross Darren A.E.
Published: March 2023

Supplementary Figures S1-S6. Comparison of genetic alterations across multiple populations resistant to AZD9291 and other EGFR TKIs (S1); Treatment of resistant populations with AZD9291 (S2); Detection and Validation of a novel NRAS E63K mutation (S3); Lysates were prepared from parental PC9 and resistant populations analysed for levels of total and phosphorylated ERK, NRAS and KRAS by western blot (S4); The novel NRAS E63K mutation is an activating mutation that when expressed enhances resistance to cell growth inhibition by gefitinib or AZD9291 in EGFRm cell lines (S5); In vitro combination of AZD9291 with selumetinib induces more profound phenotype inhibition (S6).
Supplementary Figures 1 through 10, Supplementary Tables 1 and 2, an Supplementary Materials and Methods from Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf–DAPK Complex by Raf Inhibitor Combination Therapy
Authors: Tsai Yi-Ta , Chuang Mei-Jen , Tang Shou-Hung , Wu Sheng-Tang , Chen Yu-Chi , Sun Guang-Huan , Hsiao Pei-Wen , Huang Shih-Ming , Lee Hwei-Jen , Yu Cheng-Ping , Ho Jar-Yi , Lin Hui-Kuan , Chen Ming-Rong , Lin Chung-Chih , Chang Sun-Yran , Lin Victor C. , Yu Dah-Shyong , Cha Tai-Lung
Published: March 2023

Supplementary Figures 1-10. Suppl. Fig. 1. The cell death caused by Raf inhibitors in RCC cells in vitro and in vivo. Suppl. Fig. 2.S-G combination therapy synergistically induced C-Raf-dependent cell death. Suppl. Fig. 3.S-G combination therapy induced mitochondrial dysfunction and ROS generation. Suppl. Fig. 4. S-G combination therapy induced ROS-dependent cell death and de-phosphorylation of pDAPKS308. Suppl. Fig. 5. The generation of sorafenib-monotherapy resistant cancer cell lines in vivo. Suppl. Fig. 6.S308 phosphorylation status of DAPK did not affect cell proliferation of cancer cells and knock-down of DAPK attenuated cell death of cancer cells sensitive to S-G combination therapy. Suppl. Fig. 7.S-G combination therapy induced C-Raf/pDAPKS308 complex translocation from the mitochondria to the cytoplasm of A498 cancer cells. Suppl. Fig. 8.S-G combination therapy induced mitochondrial morphological change of cancer cells expressing DAPKS308D.Suppl. Fig. 9.DAPKS308D enhanced PMA induced mitochondrial remodelling. Suppl. Fig. 10. S-G combination therapy induced PP2A dissociation from C-Raf/pDAPKS308 complex concomitant with de-phosphorylation of pDAPKS308. Supplementary Tables 1-2. Supplementary Table 1. Clinical characteristics of the drug-resistant RCC patients whose tumors were primarily cultured into stable cancer cell lines. Supplementary Table 2.Correlation of pDAPKS308 expression with clinical and pathological features of 181 patients with renal cell carcinoma. Supplementary materials and methods - Supplemental Experimental Procedures
Supplementary Table 1 from Chemoradiotherapy-Induced Upregulation of PD-1 Antagonizes Immunity to HPV-Related Oropharyngeal Cancer
Authors: Parikh Falguni , Duluc Dorothée , Imai Naoko , Clark Amelia , Misiukiewicz Krzys , Bonomi Marcello , Gupta Vishal , Patsias Alexis , Parides Michael , Demicco Elizabeth G. , Zhang David Y. , Kim-Schulze Seunghee , Kao Johnny , Gnjatic Sacha , Oh Sangkon , Posner Marshall R. , Sikora Andrew G.
Published: March 2023

Supplementary Table 1. Absolute Numbers for immune population
Supplementary Figure S3 from Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma
Authors: Schmithals Christian , Köberle Verena , Korkusuz Hüdayi , Pleli Thomas , Kakoschky Bianca , Augusto Eduardo Alonso , Ibrahim Ahmed Atef , Arencibia Jose M. , Vafaizadeh Vida , Groner Bernd , Korf Horst-Werner , Kronenberger Bernd , Zeuzem Stefan , Vogl Thomas J. , Waidmann Oliver , Piiper Albrecht
Published: March 2023

Supplementary Figure S3: Body weight of HepG2 (A) and Huh-7 (B) xenograft-bearing mice treated with iRGD, control (Ctl.) peptide, PBS and sorafenib (Sora).
Supplemental Table 1 from Mig-6 Suppresses Endometrial Cancer Associated with Pten Deficiency and ERK Activation
Authors: Kim Tae Hoon , Yoo Jung-Yoon , Kim Hong Im , Gilbert Jenifer , Ku Bon Jeong , Li Jane , Mills Gordon B. , Broaddus Russell R. , Lydon John P. , Lim Jeong Mook , Yoon Ho-Geun , Jeong Jae-Wook
Published: March 2023

Supplemental Table 1. PCR primers
Supplemental Figure 4 from Mig-6 Suppresses Endometrial Cancer Associated with Pten Deficiency and ERK Activation
Authors: Kim Tae Hoon , Yoo Jung-Yoon , Kim Hong Im , Gilbert Jenifer , Ku Bon Jeong , Li Jane , Mills Gordon B. , Broaddus Russell R. , Lydon John P. , Lim Jeong Mook , Yoon Ho-Geun , Jeong Jae-Wook
Published: March 2023

Supplemental Figure 4. Immunohistochemical analysis of ERa
Supplemental Figure 3 from Mig-6 Suppresses Endometrial Cancer Associated with Pten Deficiency and ERK Activation
Authors: Kim Tae Hoon , Yoo Jung-Yoon , Kim Hong Im , Gilbert Jenifer , Ku Bon Jeong , Li Jane , Mills Gordon B. , Broaddus Russell R. , Lydon John P. , Lim Jeong Mook , Yoon Ho-Geun , Jeong Jae-Wook
Published: March 2023

Supplemental Figure 3. The Development of endometrial cancer in Ptend/d and Mig-6overPtend/d mice.
Supplementary Methods and References from Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis
Authors: Kirane Amanda , Ludwig Kathleen F. , Sorrelle Noah , Haaland Gry , Sandal Tone , Ranaweera Renate , Toombs Jason E. , Wang Miao , Dineen Sean P. , Micklem David , Dellinger Michael T. , Lorens James B. , Brekken Rolf A.
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure S4 from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Authors: Ito-Kureha Taku , Koshikawa Naohiko , Yamamoto Mizuki , Semba Kentaro , Yamaguchi Noritaka , Yamamoto Tadashi , Seiki Motoharu , Inoue Jun-ichiro
Published: March 2023

Supplementary Figure S4. TMOD1 enhances nuclear translocation of β-catenin in MDA-MB-436 cells and BT-549 cells.
Supplemental Figure 1 from CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110
Authors: Hu Shanhu , Danilov Alexey V. , Godek Kristina , Orr Bernardo , Tafe Laura J. , Rodriguez-Canales Jaime , Behrens Carmen , Mino Barbara , Moran Cesar A. , Memoli Vincent A. , Mustachio Lisa Maria , Galimberti Fabrizio , Ravi Saranya , DeCastro Andrew , Lu Yun , Sekula David , Andrew Angeline S. , Wistuba Ignacio I. , Freemantle Sarah , Compton Duane A. , Dmitrovsky Ethan
Published: March 2023

Supplemental Fig. S1. Effect of wild-type or a phosphorylation sites mutant CP110 species on responses to CDK2 inhibition. (A) Overexpression of CP110 was detected in ED-1 cells with an anti-HA antibody 24 and 48 hours after transfection. (B) Overexpression of wild-type CP110 significantly reduced apoptosis induced by seliciclib treatment. ED-1 cells overexpressing CP110 were treated with the indicated dosages of seliciclib for 24 hours and analyzed for apoptosis. (C and D). Overexpression of phosphorylation-site mutated CP110 did not have a significant effect on anaphase catastrophe or apoptosis induced by CDK2 inhibition. ED-1 cells overexpressing a mutant-CP110 species were treated with the indicated dosages of seliciclib for 24 hours or transfected individually with two different siRNAs targeting CDK2 for 24 hours and (C) scored for multipolar anaphase and (D) analyzed for apoptosis. (E). Seliciclib treatment did not appreciably affect CP110 basal levels in human and murine lung cancer cells. Hop62 and ED-1 were treated with various dosages of seliclcib and CP110 levels were examined after 24 and 48 hours of treatment.
Supplementary Table 3 from PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia
Authors: Bräuer-Hartmann Daniela , Hartmann Jens-Uwe , Wurm Alexander Arthur , Gerloff Dennis , Katzerke Christiane , Verga Falzacappa Maria Vittoria , Pelicci Pier Giuseppe , Müller-Tidow Carsten , Tenen Daniel G. , Niederwieser Dietger , Behre Gerhard
Published: March 2023

Primer sequences used for mRNA applification by qPCR.
Supplementary Table 1 from PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia
Authors: Bräuer-Hartmann Daniela , Hartmann Jens-Uwe , Wurm Alexander Arthur , Gerloff Dennis , Katzerke Christiane , Verga Falzacappa Maria Vittoria , Pelicci Pier Giuseppe , Müller-Tidow Carsten , Tenen Daniel G. , Niederwieser Dietger , Behre Gerhard
Published: March 2023

Genetic and morphological characteristics of APL patients used for miR-181a/b expression analysis.
Supplementary Figure 2 from Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Wilson Katheryne E. , Tian Lu , Lutz Amelie M. , Willmann Jürgen K.
Published: March 2023

Supplementary Figure 2. Microvessel density in whole tissue breast cancer samples.
Supplementary Table 1 from NF-κB: Regulation by Methylation
Authors: Lu Tao , Stark George R.
Published: March 2023

Methylation of NF-κB, genetic alteration of PRMT5 and hypothetical model.
Supplementary Figure Legend from Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
Authors: Soucheray Margaret , Capelletti Marzia , Pulido Inés , Kuang Yanan , Paweletz Cloud P. , Becker Jeffrey H. , Kikuchi Eiki , Xu Chunxiao , Patel Tarun B. , Al-shahrour Fatima , Carretero Julián , Wong Kwok-Kin , Jänne Pasi A. , Shapiro Geoffrey I. , Shimamura Takeshi
Published: March 2023

Supplementary Figure Legend from Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
Supplementary Table Legends from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: March 2023

Legend for Supplementary Tables S1-S7.
Supplemental Figure Legends from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: March 2023

Supplemental Figure Legends. Figure legends accompanying all supplementary figures and table.
Supplementary Figure S3 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: March 2023

Plasma and liver concentrations of sorafenib in wildtype, Abcc3(-/-) mice, Oatp1a/1b(-/-), and combination Abcc2(-/-) and Abcc3(-/-) mice.
Supplementary Table 2 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: March 2023

Ratio of CD4 and CD8 on Cetux-CAR+ and Nimo-CAR+ T cells
Supplementary Figure S2 from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: March 2023

Supplementary Figure S2. (-)-Nutlin-3 activates p53 in p53WT cells and induces caspase-independent cell death.
Supplementary Table 1 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: March 2023

Antibodies used in study
sup figure legend from Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma
Authors: Yamada Tadaaki , Amann Joseph M. , Fukuda Koji , Takeuchi Shinji , Fujita Naoya , Uehara Hisanori , Iwakiri Shotaro , Itoi Kazumi , Shilo Konstantin , Yano Seiji , Carbone David P.
Published: March 2023

Supplemental Figure legends 1-6
Legends for Supplementary Tables S1 and S2 from Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer
Authors: Kuhnert Frank , Chen Guoying , Coetzee Sandra , Thambi Nithya , Hickey Carlos , Shan Jing , Kovalenko Pavel , Noguera-Troise Irene , Smith Eric , Fairhurst Jeanette , Andreev Julian , Kirshner Jessica R. , Papadopoulos Nicholas , Thurston Gavin
Published: March 2023

Legends for Supplementary Tables S1 and S2
Suppl Table S6 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: March 2023

Suppl Table S6. MVA of miR-138 activity signature
Supplementary figure 4 from Decoy Receptor DcR1 Is Induced in a p50/Bcl3–Dependent Manner and Attenuates the Efficacy of Temozolomide
Authors: Mansour Nassir M. , Bernal Giovanna M. , Wu Longtao , Crawley Clayton D. , Cahill Kirk E. , Voce David J. , Balyasnikova Irina V. , Zhang Wei , Spretz Ruben , Nunez Luis , Larsen Gustavo F. , Weichselbaum Ralph R. , Yamini Bakhtiar
Published: March 2023

Supplementary figure 4. A, clonogenic assay in U87 cells treated with Fas ligand (30 ng/ml) and/or FNAb (1 μg/ml). B, clonogenic assay in U87 cells transfected with the indicated siRNA following treatment with vehicle or Fas ligand (30 ng/ml). Data is normalized to vehicle for each si-RNA condition. C, clonogenic assay in U87 cells expressing empty vector (EV) or HA-DcR1 following treatment with Fas ligand (30 ng/ml). *, P < 0.05. D, tumor growth curves of U87 hindlimb xenografts (n = 5 mice per group) treated with the indicated combinations of TMZ and/or NPs carrying the indicated siRNA. Treatments were given as shown. *, P < 0.05, TMZ + NP-si-DcR1 vs. TMZ + NP-si-cntl.
Supplementary Figure 8 from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Authors: Lo Albert , Wang Liang-Chuan S. , Scholler John , Monslow James , Avery Diana , Newick Kheng , O'Brien Shaun , Evans Rebecca A. , Bajor David J. , Clendenin Cynthia , Durham Amy C. , Buza Elizabeth L. , Vonderheide Robert H. , June Carl H. , Albelda Steven M. , Puré Ellen
Published: March 2023

Combination of FAP-CAR T cells and gemcitabine treatment augments anti-tumor response in 4662 tumors.
Supplementary Figure 4 from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Authors: Lo Albert , Wang Liang-Chuan S. , Scholler John , Monslow James , Avery Diana , Newick Kheng , O'Brien Shaun , Evans Rebecca A. , Bajor David J. , Clendenin Cynthia , Durham Amy C. , Buza Elizabeth L. , Vonderheide Robert H. , June Carl H. , Albelda Steven M. , Puré Ellen
Published: March 2023

Alteration of tumor structure by FAP-CAR T cells in A549 tumors.
Supplementary Table S2 from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications
Authors: Gámez-Pozo Angelo , Berges-Soria Julia , Arevalillo Jorge M. , Nanni Paolo , López-Vacas Rocío , Navarro Hilario , Grossmann Jonas , Castaneda Carlos A. , Main Paloma , Díaz-Almirón Mariana , Espinosa Enrique , Ciruelos Eva , Fresno Vara Juan Ángel
Published: March 2023

Supplementary Table S2. List and quantification values of 1,095 proteins.
Supplementary Table S3 from PLK1 Phosphorylates PAX3-FOXO1, the Inhibition of Which Triggers Regression of Alveolar Rhabdomyosarcoma
Authors: Thalhammer Verena , Lopez-Garcia Laura A. , Herrero-Martin David , Hecker Regina , Laubscher Dominik , Gierisch Maria E. , Wachtel Marco , Bode Peter , Nanni Paolo , Blank Bernd , Koscielniak Ewa , Schäfer Beat W.
Published: March 2023

Supplementary Table S3. PAX3-FOXO1 phospho-peptides identified by mass spectrometry.
Supplementary Materials and Methods from PLK1 Phosphorylates PAX3-FOXO1, the Inhibition of Which Triggers Regression of Alveolar Rhabdomyosarcoma
Authors: Thalhammer Verena , Lopez-Garcia Laura A. , Herrero-Martin David , Hecker Regina , Laubscher Dominik , Gierisch Maria E. , Wachtel Marco , Bode Peter , Nanni Paolo , Blank Bernd , Koscielniak Ewa , Schäfer Beat W.
Published: March 2023

Supplementary Materials and Methods. Description of additional methods and procedures used in the study.
Supplementary Figures S1-S13 and Table S1 from KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78
Authors: Kang Jin Muk , Park Sujin , Kim Staci Jakyong , Kim Hyojung , Lee Bona , Kim Junil , Park Jinah , Kim Shin Tae , Yang Han-Kwang , Kim Woo Ho , Kim Seong-Jin
Published: March 2023

Supplementary Figures S1-S13 and Table S1. Confirmation of KIAA1324 mRNA expression in primary tissues from gastric cancer (GC) patients and GC cell lines (S1). Analysis of correlation between copy number variation (CNV) and KIAA1324 mRNA expression in gastric cancer cell lines (S2). KIAA1324 enhanced cisplatin- and etoposide-induced apoptosis of gastric cancer cells (S3). KIAA1324 knockdown reduced staurosporine-induced apoptosis (S4). KIAA1324 did not have a considerable effect on cell cycle (S5). KIAA1324 did not affect autophagy of gastric cancer cells (S6). KIAA1324 â–³C caused growth inhibition and apoptosis in gastric cancer cells (S7). KIAA1324 â–³N did not induce apoptosis of gastric cancer cells (S8). 1-303 a.a. of KIAA1324 was required for KIAA1324-mediated apoptosis (S9). Subcellular localization of KIAA1324 (S10). 1-303 a.a. of KIAA1324 bound to GRP78. (A) A schematic model of KIAA1324 fragments (S11). GRP78 knockdown induced apoptosis of MKN28 cells (S12). A schematic model of the anti-tumorigenic ability of KIAA1324 through regulation of GRP78 activity (S13). Semi-quantitative and quantitative RT-PCR primers (Table S1).
Supplementary Figure S4 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Authors: Khan Sheema , Ebeling Mara C. , Chauhan Neeraj , Thompson Paul A. , Gara Rishi K. , Ganju Aditya , Yallapu Murali M. , Behrman Stephen W. , Zhao Haotian , Zafar Nadeem , Singh Man Mohan , Jaggi Meena , Chauhan Subhash C.
Published: March 2023

Supplementary Figure S4. Schematic representation of the treatment regime of xenograft mice.
Supplementary Figure S2 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Authors: Khan Sheema , Ebeling Mara C. , Chauhan Neeraj , Thompson Paul A. , Gara Rishi K. , Ganju Aditya , Yallapu Murali M. , Behrman Stephen W. , Zhao Haotian , Zafar Nadeem , Singh Man Mohan , Jaggi Meena , Chauhan Subhash C.
Published: March 2023

Supplementary Figure S2. Effect of GDC-0449 and ORM on proliferation, clonogenicity and invasion of PDAC cells.
Supplementary Table S1 from Genetic Deletion of AEG-1 Prevents Hepatocarcinogenesis
Authors: Robertson Chadia L. , Srivastava Jyoti , Siddiq Ayesha , Gredler Rachel , Emdad Luni , Rajasekaran Devaraja , Akiel Maaged , Shen Xue-Ning , Guo Chunqing , Giashuddin Shah , Wang Xiang-Yang , Ghosh Shobha , Subler Mark A. , Windle Jolene J. , Fisher Paul B. , Sarkar Devanand
Published: March 2023

Differential count of bone marrow cells (% of total cell count).
Supplementary Figure S2 from Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain
Authors: Chen Jinyu , Lee Ho-Jeong , Wu Xuefeng , Huo Lei , Kim Sun-Jin , Xu Lei , Wang Yan , He Junqing , Bollu Lakshmi R. , Gao Guang , Su Fei , Briggs James , Liu Xiaojing , Melman Tamar , Asara John M. , Fidler Isaiah J. , Cantley Lewis C. , Locasale Jason W. , Weihua Zhang
Published: March 2023

Supplementary Figure S2. Brain Metastatic Cells Contain High Levels of Glycogen
Supplementary Figure Legends from Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer
Authors: Diefenbacher Markus E. , Chakraborty Atanu , Blake Sophia M. , Mitter Richard , Popov Nikita , Eilers Martin , Behrens Axel
Published: March 2023

Legends for Supplementary Figures S1-S4.