bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Solar Power Generation in Urban Industrial Blocks: The Impact of Block Typology and PV Material Performance
Authors: Wang Minghao , Li Ting , Li Chunfang , Zhou Haizhu , Ju Xiaolei , Tang Wensheng , Han Yunsong , Xu Shen
Published: June 2024

The block-scale application of photovoltaic technology in cities is becoming a viable solution for renewable energy utilization. The rapid urbanization process has provided urban buildings with a colossal development potential for solar energy in China, especially in industrial areas that provide more space for the integration of PV equipment. In developing solar energy resources, the block layout and the PV materials are two critical factors affecting the distribution of solar radiation and generation. However, few studies have analyzed how to select the most suitable PV materials for different layouts of industrial blocks to obtain the best generation. This study considered the layout of industrial blocks and PV materials simultaneously, and the generation yield was calculated when combined. A total of 40 real industrial block cases were constructed, and radiation distribution data on building surfaces of different block cases were calculated. Data on both were combined to calculate the generation of different PV materials for each block type. The findings indicated that single-story industrial blocks possessed the highest potential for solar radiation, primarily due to the higher percentage of roof area. The influence of PV materials on the installation rate of different building facades varied, with the installation rate of the west facade being the most impacted by PV performance and the roof being the least impacted. Using different PV materials in industrial blocks could lead to a 59.2% difference in solar generation capacity. For single-layer industrial blocks, mono crystalline and poly crystalline silicon were preferable to achieve higher power generation. In contrast, multi-story and high-rise industrial blocks were best suited for a-Si and CIGS to attain higher cost performance. The methods and results of this study guided the selection and installation of PV equipment in various block typologies, thereby improving the refinement of solar resource development, maximizing solar resource utilization, and promoting the development of energy conservation and carbon reduction in cities.
Preparation of Green Sustainable Cement Paste Mixture Based on Inorganic Additives: An Experimental and Modelling Approach
Authors: Mahmood Aamir , Pechočiaková Miroslava , Noman Muhammad Tayyab , Wacławek Stanisław , Gheibi Mohammad , Behzadian Kourosh , Militký Jiří
Published: June 2024

Using waste materials in the mixture of building materials is an approach aligned with the circular economy, a viewpoint that creates sustainable building industries, especially in developed countries. This study concentrated on the application of laponite (LAP), fly ash (FA), and bentonite (BENT) materials in the mixture of cement pastes. The first step used experimental practices to examine the metrics of toughness, three-point bending, and compressive strength with different percentages of added LAP, FA, and BENT after the characterization of samples by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). The next step entailed assessment of cement paste specifications through some regressive equations obtained by the application of 2D curve fitting and sensitive analysis of additive (FA, LAP, and BENT) fluctuations in the structure of cement paste. The results show that linear polynomial equations are the best for the evaluation of cement paste terms as per different percentages of the additives. The environmental impact assessment (EIA) of nine prepared samples demonstrated that LAP created the safest condition in comparison to others. However, the ordered weighted averaging (OWA) computations applied for the sustainability assessment (SA) of the samples showed that the LAP is the most appropriate option for use in the structure of cement paste. Using experimental analysis and mathematical modeling, the behavior of cement paste interacting with mineral additives is evaluated. Sustainable mixtures are then presented based on EIA.
Evaluation of Maximum Shear Strength of Prestressed Concrete (PSC) Hollow Core Slab (HCS)
Authors: Kim Dong-Hwan , Jo Min-Su , Lim Su-A. , Kim Hyeong-Gook , Kang Seong-Won , Kim Kil-Hee
Published: June 2024

In this study, four-point load tests were conducted to evaluate the shear performance of factory-produced precast prestressed concrete hollow core slabs (HCS) assembled on-site. The test specimens were fabricated using compression molding and comprised six samples, with variables being the presence or absence of topping concrete and the shear reinforcement. According to the experimental variables, experiments were conducted using simple support beams to evaluate the shear performance and ultimate strength of HCSs. The results showed that HCSs, regardless of whether they included topping concrete or not, exhibited average values of shear strength more than 10% higher than the factored shear strength specified by concrete structure standards, confirming that these materials satisfy existing design standards. According to current standards, the overall reinforcement length should be increased to meet the minimum shear rebar placement requirements. However, the nominal shear strength of PS concrete hollow slabs exceeded the hollow design, with the ratio of experimental results ranging from 1.26 to 1.87 on average, satisfying the required performance.
Preconditioning High-Strength Boulders for TBM Tunnelling by Ground Drilling and Blasting
Authors: Zhang Qingbin , Zhang Zongxian , Yang Junsheng , Wu Congshi , Hu Min
Published: June 2024

A spherical weathering body, also called a boulder, is an element of complex geological strata and presents a significant challenge to tunnelling by a tunnel-boring machine (TBM). In this study, ground-based drilling and blasting were used to precondition boulders. To determine the specific charge needed for preconditioning blasting, model blasts were conducted, and the relationships among the specific charge, fragment size, and overburden depth in the model blasts were investigated. The determined specific charge from the model blasts was then modified by considering the overburden depth and used to precondition the boulders for practical TBM tunnelling. The results indicate the following: (1) model blasts were effective in determining the correct specific charge and predicting boulder fragment sizes resulting from blasting; (2) the boulders met in practical TBM tunnelling were successfully preconditioned by using the determined specific charge; (3) the determined specific charge was 3.26 kg/m3, corresponding to an average fragment size 4.5 cm with an overburden of zero and increased with increasing overburden; (4) fragment sizes were dependent on both the specific charge and overburden depth. Our conclusions can be used to accurately determine the specific charge instead of empirical formulas.
Computational Approach for the Development of pH-Selective PD-1/PD-L1 Signaling Pathway Inhibition in Fight with Cancer
Authors: McDowell Roderick C. , Booth Jordhan D. , McGowan Allyson , Kolodziejczyk Wojciech , Hill Glake A. , Banerjee Santanu , Feng Manliang , Kapusta Karina
Published: June 2024

Immunotherapy, particularly targeting the PD-1/PD-L1 pathway, holds promise in cancer treatment by regulating the immune response and preventing cancer cells from evading immune destruction. Nonetheless, this approach poses a risk of unwanted immune system activation against healthy cells. To minimize this risk, our study proposes a strategy based on selective targeting of the PD-L1 pathway within the acidic microenvironment of tumors. We employed in silico methods, such as virtual screening, molecular mechanics, and molecular dynamics simulations, analyzing approximately 10,000 natural compounds from the MolPort database to find potential hits with the desired properties. The simulations were conducted under two pH conditions (pH = 7.4 and 5.5) to mimic the environments of healthy and cancerous cells. The compound MolPort-001-742-690 emerged as a promising pH-selective inhibitor, showing a significant affinity for PD-L1 in acidic conditions and lower toxicity compared to known inhibitors like BMS-202 and LP23. A detailed 1000 ns molecular dynamics simulation confirmed the stability of the inhibitor-PD-L1 complex under acidic conditions. This research highlights the potential of using in silico techniques to discover novel pH-selective inhibitors, which, after experimental validation, may enhance the precision and reduce the toxicity of immunotherapies, offering a transformative approach to cancer treatment.
Cost-Effectiveness Analysis of Axicabtagene Ciloleucel vs. Standard of Care in Second-Line Treatment for Relapsed/Refractory Large B-Cell Lymphoma in Spain
Authors: Martín García-Sancho Alejandro , Presa María , Pardo Carlos , Martín-Escudero Victoria , Oyagüez Itziar , Ortiz-Maldonado Valentín
Published: June 2024

Purpose: To estimate the cost-effectiveness of axi-cel vs. salvage immunochemotherapy followed by high-dose chemotherapy and autologous stem-cell transplantation (HDT+ASCT) for responders to second-line treatment for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). Methods: A partitioned survival mixture-cure model comprising three health states was used to estimate the costs, life years gained (LYG), and quality-adjusted life years (QALYs) accumulated over a lifetime horizon. Overall survival, event-free survival, and time to the next treatment with axi-cel and HDT+ASCT were derived from the ZUMA-7 study. The total costs (EUR, 2022) included drug acquisition and administration, ASCT, subsequent treatment, disease and adverse event management, and palliative care. The unitary costs were derived from local databases and the literature. A 3% discount rate was applied to the costs and outcomes. Results: Compared with HDT+ASCT, axi-cel provided higher LYG per patient (10.00 vs. 8.28 LYG/patient) and greater QALYs gained per patient (7.85 vs. 6.04 QALY/patient). The lifetime total costs were 343,581 EUR/patient with axi-cel vs. 257,994 EUR/patient with IQT+ASCT. The incremental cost-effectiveness ratio of axi-cel vs. HDT+ASCT was 49,627 EUR/LYG, and the incremental cost-utility ratio was 47,309 EUR/QALY. Sensitivity analyses confirmed the robustness of the model. Conclusion: Axi-cel is a potentially cost-effective alternative to HDT+ASCT for the treatment of R/R DLBCL in Spain.
Gastrointestinal Stromal Tumors (GISTs) Mimicking Primary Ovarian Tumors or Metastasizing to the Ovaries: A Systematic Literature Review
Authors: Tonni Gabriele , Palicelli Andrea , Bassi Maria , Torricelli Federica , Vacca Ilaria , Aguzzoli Lorenzo , Mandato Vincenzo
Published: June 2024

Background: Gastrointestinal stromal tumors (GISTs) are a rare neoplasm, sometimes mimicking primary ovarian tumors (OTs) and/or metastasizing to the ovaries (M-OT). We performed a systematic literature review (SLR) of OTs and M-OTs, investigating differences in recurrence-free and overall survival. Methods: Our SLR was performed according to PRISMA guidelines, searching in Pubmed, Scopus, and Web of Science databases from inception until 21 April 2024. Results: Overall, 59 OTs (Group 1) and 21 M-OTs (Group 2) were retrieved. The absence of residual disease after surgery was achieved significantly in a higher percentage of patients with Group 1 GISTs (91.5%) compared with Group 2 GISTs (57.1%). Chemotherapy was more frequently administered to Group 2 patients (33% vs. 0%). Recurrence and deaths for disease were significantly more frequent in Group 2 than Group 1 cases (54.5% vs. 6.8%, and 37.5% vs. 9.8%, respectively). Conclusions: GISTs can rarely mimic primary ovarian cancers or even more rarely metastasize to the ovaries. Group 1 GISTs occurred in younger women, were not associated with elevated tumor markers, and had a better prognosis. In contrast, Group 2 GISTs occurred in older women, may exhibit elevated tumor markers, and presented a worse prognosis. However, no significant statistical difference for survival between the two studied groups was detected. Computed tomography scans can define the size of GISTs, which correlate to stage and prognostic risk classes. The gold standard treatment is complete surgical resection, which was achieved in almost all cases of Group 1 GISTs and in half of Group 2. Histopathology and immunohistochemistry are essential for the final diagnosis and guide chemotherapy treatment.
Multiparametric Ultrasound for Focal Testicular Pathology: A Ten-Year Retrospective Review
Authors: Huang Dean Y. , Alsadiq Majed , Yusuf Gibran T. , Deganello Annamaria , Sellars Maria E. , Sidhu Paul S.
Published: June 2024

Conventional ultrasonography (US), including greyscale imaging and colour Doppler US (CDUS), is pivotal for diagnosing scrotal pathologies, but it has limited specificity. Historically, solid focal testicular abnormalities often led to radical orchidectomy. This retrospective study evaluated the utilisation of contrast-enhanced ultrasound (CEUS) and strain elastography (SE) in investigating intratesticular focal abnormalities. A total of 124 cases were analysed. This study underscored the superior diagnostic capabilities of CEUS in detecting vascular enhancement in all malignant cases, even those with undetectable vascularity by CDUS. It also highlighted the potential of CEUS in identifying distinctive vascular patterns in benign vascular tumours. Definitive confirmation of benignity could be obtained when the absence of enhancement was demonstrated on CEUS. While SE alone offered no distinctive advantage in differentiating between benign and malignant pathologies, we demonstrated that incorporating a combination of CEUS and SE into the evaluation of focal testicular abnormalities could improve diagnostic performance metrics over conventional CDUS. Our findings underscore the role of advanced ultrasound techniques in enhancing the evaluation of focal testicular abnormalities in clinical practice and could aid a shift towards testis-sparing management strategies.
Scoring System for Predicting the Risk of Liver Cancer among Diabetes Patients: A Random Survival Forest-Guided Approach
Authors: Yau Sarah Tsz-Yui , Leung Eman Yee-Man , Hung Chi-Tim , Wong Martin Chi-Sang , Chong Ka-Chun , Lee Albert , Yeoh Eng-Kiong
Published: June 2024

Background: Most liver cancer scoring systems focus on patients with preexisting liver diseases such as chronic viral hepatitis or liver cirrhosis. Patients with diabetes are at higher risk of developing liver cancer than the general population. However, liver cancer scoring systems for patients in the absence of liver diseases or those with diabetes remain rare. This study aims to develop a risk scoring system for liver cancer prediction among diabetes patients and a sub-model among diabetes patients without cirrhosis/chronic viral hepatitis. Methods: A retrospective cohort study was performed using electronic health records of Hong Kong. Patients who received diabetes care in general outpatient clinics between 2010 and 2019 without cancer history were included and followed up until December 2019. The outcome was diagnosis of liver cancer during follow-up. A risk scoring system was developed by applying random survival forest in variable selection, and Cox regression in weight assignment. Results: The liver cancer incidence was 0.92 per 1000 person-years. Patients who developed liver cancer (n = 1995) and those who remained free of cancer (n = 1969) during follow-up (median: 6.2 years) were selected for model building. In the final time-to-event scoring system, presence of chronic hepatitis B/C, alanine aminotransferase, age, presence of cirrhosis, and sex were included as predictors. The concordance index was 0.706 (95%CI: 0.676–0.741). In the sub-model for patients without cirrhosis/chronic viral hepatitis, alanine aminotransferase, age, triglycerides, and sex were selected as predictors. Conclusions: The proposed scoring system may provide a parsimonious score for liver cancer risk prediction among diabetes patients.
Unsupervised Analysis Reveals the Involvement of Key Immune Response Genes and the Matrisome in Resistance to BRAF and MEK Inhibitors in Melanoma
Authors: Liu-Smith Feng , Lin Jianjian
Published: June 2024

Melanoma tumors exhibit a wide range of heterogeneity in genomics even with shared mutations in the MAPK pathway, including BRAF mutations. Consistently, adaptive drug resistance to BRAF inhibitors and/or BRAF plus MEK inhibitors also exhibits a wide range of heterogeneous responses, which poses an obstacle for discovering common genes and pathways that can be used in clinic for overcoming drug resistance. This study objectively analyzed two sets of previously published tumor genomics data comparing pre-treated melanoma tumors and BRAFi- and/or MEKi-resistant tumors. Heterogeneity in response to BRAFi and BRAFi/MEKi was evident because the pre-treated tumors and resistant tumors did not exhibit a tendency of clustering together. Differentially expressed gene (DEG) analysis revealed eight genes and two related enriched signature gene sets (matrisome and matrisome-associated signature gene sets) shared by both sets of data. The matrisome was closely related to the tumor microenvironment and immune response, and five out of the eight shared genes were also related to immune response. The PLXNC1 gene links the shared gene set and the enriched signature gene sets as it presented in all analysis results. As the PLXNC1 gene was up-regulated in the resistant tumors, we validated the up-regulation of this gene in a laboratory using vemurafenib-resistant cell lines. Given its role in promoting inflammation, this study suggests that resistant tumors exhibit an inflammatory tumor microenvironment. The involvement of the matrisome and the specific set of immune genes identified in this study may provide new opportunities for developing future therapeutic methods.
The Impact of Expert Pathology Review and Molecular Diagnostics on the Management of Sarcoma Patients: A Prospective Study of the Hellenic Group of Sarcomas and Rare Cancers
Authors: Kokkali Stefania , Boukovinas Ioannis , de Bree Eelco , Koumarianou Anna , Georgoulias Vassilis , Kyriazoglou Anastasios , Tsoukalas Nikolaos , Memos Nikolaos , Papanastassiou John , Stergioula Anastasia , Tsapakidis Konstantinos , Loga Konstantia , Duran-Moreno Jose , Papanastasopoulos Panagiotis , Vassos Nikolaos , Kontogeorgakos Vasileios , Athanasiadis Ilias , Mahaira Luiza , Dimitriadis Efthymios , Papachristou Dionysios J. , Agrogiannis George
Published: June 2024

Precise classification of sarcomas is crucial to optimal clinical management. In this prospective, multicenter, observational study within the Hellenic Group of Sarcoma and Rare Cancers (HGSRC), we assessed the effect of expert pathology review, coupled with the application of molecular diagnostics, on the diagnosis and management of sarcoma patients. Newly diagnosed sarcoma patients were addressed by their physicians to one of the two sarcoma pathologists of HGSRC for histopathological diagnostic assessment. RNA next-generation sequencing was performed on all samples using a platform targeting 86 sarcoma gene fusions. Additional molecular methods were performed in the opinion of the expert pathologist. Therefore, the expert pathologist provided a final diagnosis based on the histopathological findings and, when necessary, molecular tests. In total, 128 specimens from 122 patients were assessed. Among the 119 cases in which there was a preliminary diagnosis by a non-sarcoma pathologist, there were 37 modifications in diagnosis (31.1%) by the sarcoma pathologist, resulting in 17 (14.2%) modifications in management. Among the 110 cases in which molecular tests were performed, there were 29 modifications in diagnosis (26.4%) through the genomic results, resulting in 12 (10.9%) modifications in management. Our study confirms that expert pathology review is of utmost importance for optimal sarcoma diagnosis and management and should be assisted by molecular methods in selected cases.
Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility
Authors: Artimovič Peter , Badovská Zuzana , Toporcerová Silvia , Špaková Ivana , Smolko Lukáš , Sabolová Gabriela , Kriváková Eva , Rabajdová Miroslava
Published: June 2024

Successful pregnancy depends on precise molecular regulation of uterine physiology, especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by inflammatory changes but also by environmental factors, represents a constant threat to this delicate balance. Oxidative stress induces a reciprocally regulated nuclear factor erythroid 2-related factor 2/peroxisome proliferator-activated receptor-gamma (Nrf2/PPARγ) pathway. However, increased PPARγ activity appears to be a double-edged sword in endometrial physiology. Activated PPARγ attenuates inflammation and attenuates OS to restore redox homeostasis. However, it also interferes with physiological processes during the menstrual cycle, such as hormonal signaling and angiogenesis. This review provides an elucidation of the molecular mechanisms that support the interplay between PPARγ and OS. Additionally, it offers fresh perspectives on the Nrf2/PPARγ pathway concerning endometrial receptivity and its potential implications for infertility.
Light Sensing beyond Vision: Focusing on a Possible Role for the FICZ/AhR Complex in Skin Optotransduction
Authors: Guarnieri Tiziana
Published: June 2024

Although our skin is not the primary visual organ in humans, it acts as a light sensor, playing a significant role in maintaining our health and overall well-being. Thanks to the presence of a complex and sophisticated optotransduction system, the skin interacts with the visible part of the electromagnetic spectrum and with ultraviolet (UV) radiation. Following a brief overview describing the main photosensitive molecules that detect specific electromagnetic radiation and their associated cell pathways, we analyze their impact on physiological functions such as melanogenesis, immune response, circadian rhythms, and mood regulation. In this paper, we focus on 6-formylindolo[3,2-b]carbazole (FICZ), a photo oxidation derivative of the essential amino acid tryptophan (Trp). This molecule is the best endogenous agonist of the Aryl hydrocarbon Receptor (AhR), an evolutionarily conserved transcription factor, traditionally recognized as a signal transducer of both exogenous and endogenous chemical signals. Increasing evidence indicates that AhR is also involved in light sensing within the skin, primarily due to its ligand FICZ, which acts as both a chromophore and a photosensitizer. The biochemical reactions triggered by their interaction impact diverse functions and convey crucial data to our body, thus adding a piece to the complex puzzle of pathways that allow us to decode and elaborate environmental stimuli.
Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer
Authors: D’Amico Maria , De Amicis Francesca
Published: June 2024

Regulated cell death, a regulatory form of cell demise, has been extensively studied in multicellular organisms. It plays a pivotal role in maintaining organismal homeostasis under normal and pathological conditions. Although alterations in various regulated cell death modes are hallmark features of tumorigenesis, they can have divergent effects on cancer cells. Consequently, there is a growing interest in targeting these mechanisms using small-molecule compounds for therapeutic purposes, with substantial progress observed across various human cancers. This review focuses on summarizing key signaling pathways associated with apoptotic and autophagy-dependent cell death. Additionally, it explores crucial pathways related to other regulated cell death modes in the context of cancer. The discussion delves into the current understanding of these processes and their implications in cancer treatment, aiming to illuminate novel strategies to combat therapy resistance and enhance overall cancer therapy.
2-Methoxyestradiol, an Endogenous 17β-Estradiol Metabolite, Induces Antimitogenic and Apoptotic Actions in Oligodendroglial Precursor Cells and Triggers Endoreduplication via the p53 Pathway
Authors: Schaufelberger Sara. A. , Schaettin Martina , Azzarito Giovanna , Rosselli Marinella , Leeners Brigitte , Dubey Raghvendra K.
Published: June 2024

The abnormal growth of oligodendrocyte precursor cells (OPCs) significantly contributes to the progression of glioblastoma tumors. Hence, molecules that block OPC growth may be of therapeutic importance in treating gliomas. 2-Methoxyestradiol (2ME), an endogenous tubulin-interacting metabolite of estradiol, is effective against multiple proliferative disorders. Based on its anti-carcinogenic and anti-angiogenic actions, it is undergoing phase II clinical trials. We hypothesize that 2ME may prevent glioma growth by targeting OPC growth. Here, we tested this hypothesis by assessing the impact of 2ME on the growth of an OPC line, “Oli-neu”, and dissected the underlying mechanism(s). Treatment with 2ME inhibited OPC growth in a concentration-dependent manner, accompanied by significant upregulation in the expression of p21 and p27, which are negative cell-cycle regulators. Moreover, treatment with 2ME altered OPC morphology from multi-arm processes to rounded cells. At concentrations of 1uM and greater, 2ME induced apoptosis, with increased expressions of caspase 3, PARP, and caspase-7 fragments, externalized phosphatidylserine staining/APOPercentage, and increased mitochondrial activity. Flow cytometry and microscopic analysis demonstrated that 2ME triggers endoreduplication in a concentration-dependent fashion. Importantly, 2ME induced cyclin E, JNK1/2, and p53 expression, as well as OPC fusion, which are key mechanisms driving endoreduplication and whole-genome duplication. Importantly, the inhibition of p53 with pifithrin-α rescued 2ME-induced endoreduplication. The pro-apoptotic and endoreduplication actions of 2ME were accompanied by the upregulation of survivin, cyclin A, Cyclin B, Cyclin D2, and ppRB. Similar growth inhibitory, apoptotic, and endoreduplication effects of 2ME were observed in CG4 cells. Taken together, our findings provide evidence that 2ME not only inhibits OPC growth and triggers apoptosis, but also activates OPCs into survival (fight or flight) mode, leading to endoreduplication. This inherent survival characteristic of OPCs may, in part, be responsible for drug resistance in gliomas, as observed for many tubulin-interacting drugs. Importantly, the fate of OPCs after 2ME treatment may depend on the cell-cycle status of individual cells. Combining tubulin-interfering molecules with drugs such as pifithrin-α that inhibit endoreduplication may help inhibit OPC/glioma growth and limit drug resistance.
The Role of Retinoic Acid in Spermatogenesis and Its Application in Male Reproduction
Authors: Zhao Yue , Deng Shoulong , Li Chongyang , Cao Jingchao , Wu Aowu , Chen Mingming , Ma Xuehai , Wu Sen , Lian Zhengxing
Published: June 2024

Spermatogenesis in mammalian testes is essential for male fertility, ensuring a continuous supply of mature sperm. The testicular microenvironment finely tunes this process, with retinoic acid, an active metabolite of vitamin A, serving a pivotal role. Retinoic acid is critical for various stages, including the differentiation of spermatogonia, meiosis in spermatogenic cells, and the production of mature spermatozoa. Vitamin A deficiency halts spermatogenesis, leading to the degeneration of numerous germ cells, a condition reversible with retinoic acid supplementation. Although retinoic acid can restore fertility in some males with reproductive disorders, it does not work universally. Furthermore, high doses may adversely affect reproduction. The inconsistent outcomes of retinoid treatments in addressing infertility are linked to the incomplete understanding of the molecular mechanisms through which retinoid signaling governs spermatogenesis. In addition to the treatment of male reproductive disorders, the role of retinoic acid in spermatogenesis also provides new ideas for the development of male non-hormone contraceptives. This paper will explore three facets: the synthesis and breakdown of retinoic acid in the testes, its role in spermatogenesis, and its application in male reproduction. Our discussion aims to provide a comprehensive reference for studying the regulatory effects of retinoic acid signaling on spermatogenesis and offer insights into its use in treating male reproductive issues.
Electrochemical, Structural and Thermodynamic Investigations of Methanolic Parsley Extract as a Green Corrosion Inhibitor for C37 Steel in HCl
Authors: Boutoumit Aomar , Elhawary Maha , Bellaouchou Abdelkbir , Boudalia Maria , Hammani Othmane , José Garcia Anton , Amin Hatem M. A.
Published: June 2024

Phytochemical-rich natural extracts have recently attracted intense attention as green corrosion inhibitors and costly benign coating components for the protection of metallic structures of immense commercial importance. Herein, various methods were applied to assess the corrosion protection efficiency of a methanolic extract of parsley (Petroselinum crispum) (PCE) on carbon steel C37 in 1 M HCl. Initially, the chemical profile of PCE was analyzed using gas chromatography/mass spectrometry (GC/MS), and myristicin and apiol were identified as the main components. The results from the weight loss, electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PDP) techniques revealed a substantial reduction in the corrosion rate upon the use of PCE, with a maximum inhibition efficiency of 92% at 1 g L−1 PCE. To optimize the performance, the corrosion behavior was investigated over a temperature range of 303–333 K and for concentrations of 0.1–1 g L−1. The inhibition effectiveness increased at higher concentrations of PCE, whilst it decreased when the temperature was elevated. The query suggests that the adsorption process involves both physical and chemical mechanisms. The adsorption of PCE onto C37 was well described by the Langmuir adsorption isotherm. The data were used to determine the activation energy and thermodynamic parameters. The PCE coating acted as a mixed-type inhibitor, hampering both cathodic and anodic corrosion reactions. SEM further confirmed the formation of a protective coating film on the steel surface when exposed to PCE. UV-Vis and XRD were implemented to understand the inhibition mechanism and formed products at the microscopic and spectroscopic levels. Hence, the green PCE inhibitor may potentially be applied in corrosion mitigation due to its high corrosion protection efficacy and its environmentally benign nature.
A Review of Research on Improving Wear Resistance of Titanium Alloys
Authors: Chen Yazhou , Zhang Honggang , Wang Bitao , Huang Jianyong , Zhou Meihong , Wang Lei , Xi Yuntao , Jia Hongmin , Xu Shanna , Liu Haitao , Wen Lei , Xiao Xinke , Liu Ruifan , Ji Jiangtao
Published: June 2024

Titanium alloy is widely used as oil drill pipe material because of its light weight, high strength, good toughness, corrosion resistance, fatigue resistance, and good process performance. However, due to its low hardness, poor wear resistance, serious oxidation at high temperature (700 °C), and difficulty in lubrication, in oil and gas field exploration and development drilling, especially in deep wells, high displacement wells, horizontal wells, and highly deviated wells, wear and tear are prone to occur. The application and development of titanium alloys are greatly limited. This paper introduces the research status of the common surface modification technologies of titanium alloys, such as laser cladding, magnetron sputtering, plasma spraying, micro arc oxidation, etc. It points out the improvement effect of various modification technologies on the wear resistance and high-temperature oxidation resistance of titanium alloys and discusses the advantages and disadvantages of various modification technologies. A proposed method for enhancing the wear resistance and high-temperature oxidation resistance of titanium alloys was finally introduced, and its potential for future development was investigated.
Plasma-Sprayed Osseoconductive Hydroxylapatite Coatings for Endoprosthetic Hip Implants: Phase Composition, Microstructure, Properties, and Biomedical Functions
Authors: Heimann Robert B.
Published: June 2024

This contribution attempts to provide a state-of-the-art account of the physicochemical and biomedical properties of the plasma-sprayed hydroxylapatite (HAp) coatings that are routinely applied to the surfaces of metallic endoprosthetic and dental root implants designed to replace or restore the lost functions of diseased or damaged tissues of the human body. Even though the residence time of powder particles of HAp in the plasma jet is extremely short, the high temperature applied induces compositional and structural changes in the precursor HAp that severely affect its chemical and physical properties and in turn its biomedical performance. These changes are based on the incongruent melting behavior of HAp and can be traced, among many other analytical techniques, by high resolution synchrotron X-ray diffraction, vibrational (Raman) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. In vivo reactions of the plasma-sprayed coatings to extracellular fluid (ECF) can be assessed and predicted by in vitro testing using simulated body fluids (SBFs) as proxy agents. Ways to safeguard the appropriate biological performance of HAp coatings in long-term service by controlling their phase content, porosity, surface roughness, residual stress distribution, and adhesion to the implant surface are being discussed.
A New Record of Bufo gargarizans Complex (Bufonidae, Anura) from Truong Son Mounts, Ha Tinh and Ha Giang Provinces, Vietnam Based on Molecular Evidence with a Description of a New Species
Authors: Orlov Nikolai L. , Ananjeva Natalia B. , Ermakov Oleg A. , Lukonina Svetlana A. , Ninh Hoa Thi , Nguyen Tao Thien
Published: June 2024

Based on a combination of molecular and morphological data, we herein report a new species within the bufonid Bufo gargarizans species complex. This is a widespread species complex with distribution from eastern Russia and the Korean Peninsula to China and the Ryukyu Islands of Japan. Records of this species have been documented in the Guangxi and Yunnan Provinces near the border with Vietnam and, for the first time from Vietnam, in Ha Giang Province. The new record of Bufo cf. gargarizans from Vietnam is from Ha Tinh Province. This species has never been reported from Vietnam so far south, about 550 km south from the previously known locality in Ha Giang Province. The female specimen was found in the Ha Tinh Province, Vu Quang National Park of central Vietnam and two specimens (male and female) were found Ha Giang Province. They are clearly distinguished from B. gargarizans and all the mentioned species by a specific color pattern on the belly and creamy-yellowish throat with large, bright red speckles. Genetic divergences of three Vietnam specimens from Ha Giang and Ha Tinh Provinces in the ND2 gene sequences between the B. sp. nov. and all other congeners ranged from 4.3% (with B. andrewsi) to 7.0% (with B. stejnegeri). We give a description of the morphological characters and coloration of the new record and provide an expanded diagnosis.
Overweight and Obesity in Adults with Type 1 Diabetes: A Growing Challenge
Authors: Klobučar Sanja , Detel Dijana , Igrec Miljenka , Bergoč Ajda , Rahelić Valentina , Rahelić Dario
Published: June 2024

The prevalence of obesity in adults with type 1 diabetes is increasing and reflects the rates of the general adult population. The coexistence of overweight or obesity and type 1 diabetes poses a major challenge to effective glycemic and weight management. In addition, individuals living with T1D and overweight or obesity are at greater cardiometabolic risk and are more prone to develop chronic complications in comparison to normal weight individuals with type 1 diabetes. Although obesity represents a growing challenge in the type 1 diabetes population, awareness of this issue is still low. This review provides a summary of current data on prevalence trends, causes, current strategies, and challenges in managing obesity in adults with type 1 diabetes.
The Use of 18F-Fluoride Positron Emission Tomography/Computed Tomography Scanning to Identify Sources of Pain after Posterior Lumbar Interbody Fusion—An Analysis in Patients with and without Symptoms
Authors: Peters Marloes J. M. , Brans Boudewijn T. , Broos Wouter A. M. , Jutten Elisabeth M. C. , Mottaghy Felix M. , Schijns Olaf , Weijers René E. , Willems Paul C.
Published: June 2024

Background: Identifying the cause of recurrent or persisting pain after posterior lumbar interbody fusion (PLIF) is essential for establishing optimal treatment. In this study, we evaluate patients after PLIF surgery by 18F-fluoride PET/CT scans and patient-reported outcome measures (PROMs). Methods: A total of 36 PLIF patients were included. Sixty minutes after intravenous injection of 18F-fluoride, PET/CT scanning was performed. Bone graft ingrowth, subsidence, screw loosening and damage of facet joints were scored by quantifying the level of bone metabolism of the vertebral endplates in the disc spaces, around screws and around the facet joints on the PET scans. Results: In contrast to asymptomatic patients, symptomatic patients showed abnormal PET values around pedicle screws and/or facet joints and at the lower endplates of the disc spaces, identifying a possible source of pain. On CT, no significant differences between these two groups were found. Conclusion: The PET/CT findings appeared to correlate better with symptoms on PROMs compared to CT findings alone. When interpreting 18F-fluoride PET/CT findings after PLIF surgery, one should realize bone metabolism in the disc spaces of the operated segments and around pedicle screws or facet joint changes during follow-up, reflecting natural recovery.
Benign Notochordal Cell Tumours: Case Report and Literature Review
Authors: Grabovska Dagnija , Strumfa Ilze , Ositis Janis , Liepniece-Karele Inta , Balodis Arturs
Published: June 2024

Background: Benign notochordal cell tumours (BNCTs) represent a rare entity within the spectrum of bone neoplasms, which typically arise in the axial skeleton. Although these tumours are often benign, their diagnosis and management pose significant challenges due to their histological similarity to more aggressive lesions, such as chordomas. Understanding of the clinical behaviour, diagnostic nuances, and optimal management strategies for BNCTs continues to evolve. Case Report: Benign notochordal cell tumours of the vertebra are usually asymptomatic and identified on imaging and should be distinguished from chordomas, which has a more aggressive clinical course. This report describes a 15-year-old girl with lumbosacral pain and a diagnosis of a benign notochordal cell tumour, which affects a large part of the S1 vertebra in the lumbar spine, highlighting the diagnostic challenges encountered, the role of radiological and histological investigations, and the ultimate determination of the benign nature of the tumour. Conclusions: This report highlights the approach taken for the diagnosis of a benign notochordal cell tumour of the vertebra and the importance of excluding differential diagnoses. By exploring the intricacies of this case, we contribute to the growing body of literature surrounding BNCTs, with the aim of improving clinical awareness and management strategies for this uncommon bone tumour.
Automatic Segmentation of Type A Aortic Dissection on Computed Tomography Images Using Deep Learning Approach
Authors: Guo Xiaoya , Liu Tianshu , Yang Yi , Dai Jianxin , Wang Liang , Tang Dalin , Sun Haoliang
Published: June 2024

Purpose: Type A aortic dissection (TAAD) is a life-threatening aortic disease. The tear involves the ascending aorta and progresses into the separation of the layers of the aortic wall and the occurrence of a false lumen. Accurate segmentation of TAAD could provide assistance for disease assessment and guidance for clinical treatment. Methods: This study applied nnU-Net, a state-of-the-art biomedical segmentation network architecture, to segment contrast-enhanced CT images and quantify the morphological features for TAAD. CT datasets were acquired from 24 patients with TAAD. Manual segmentation and annotation of the CT images was used as the ground-truth. Two-dimensional (2D) nnU-Net and three-dimensional (3D) nnU-Net architectures with Dice- and cross entropy-based loss functions were utilized to segment the true lumen (TL), false lumen (FL), and intimal flap on the images. Four-fold cross validation was performed to evaluate the performance of the two nnU-Net architectures. Six metrics, including accuracy, precision, recall, Intersection of Union, Dice similarity coefficient (DSC), and Hausdorff distance, were calculated to evaluate the performance of the 2D and 3D nnU-Net algorithms in TAAD datasets. Aortic morphological features from both 2D and 3D nnU-Net algorithms were quantified based on the segmented results and compared. Results: Overall, 3D nnU-Net architectures had better performance in TAAD CT datasets, with TL and FL segmentation accuracy up to 99.9%. The DSCs of TLs and FLs based on the 3D nnU-Net were 88.42% and 87.10%. For the aortic TL and FL diameters, the FL area calculated from the segmentation results of the 3D nnU-Net architecture had smaller relative errors (3.89–6.80%), compared to the 2D nnU-Net architecture (relative errors: 4.35–9.48%). Conclusions: The nnU-Net architectures may serve as a basis for automatic segmentation and quantification of TAAD, which could aid in rapid diagnosis, surgical planning, and subsequent biomechanical simulation of the aorta.
Augmenting Radiological Diagnostics with AI for Tuberculosis and COVID-19 Disease Detection: Deep Learning Detection of Chest Radiographs
Authors: Kolhar Manjur , Al Rajeh Ahmed M. , Kazi Raisa Nazir Ahmed
Published: June 2024

In this research, we introduce a network that can identify pneumonia, COVID-19, and tuberculosis using X-ray images of patients’ chests. The study emphasizes tuberculosis, COVID-19, and healthy lung conditions, discussing how advanced neural networks, like VGG16 and ResNet50, can improve the detection of lung issues from images. To prepare the images for the model’s input requirements, we enhanced them through data augmentation techniques for training purposes. We evaluated the model’s performance by analyzing the precision, recall, and F1 scores across training, validation, and testing datasets. The results show that the ResNet50 model outperformed VGG16 with accuracy and resilience. It displayed superior ROC AUC values in both validation and test scenarios. Particularly impressive were ResNet50’s precision and recall rates, nearing 0.99 for all conditions in the test set. On the hand, VGG16 also performed well during testing—detecting tuberculosis with a precision of 0.99 and a recall of 0.93. Our study highlights the performance of our deep learning method by showcasing the effectiveness of ResNet50 over traditional approaches like VGG16. This progress utilizes methods to enhance classification accuracy by augmenting data and balancing them. This positions our approach as an advancement in using state-of-the-art deep learning applications in imaging. By enhancing the accuracy and reliability of diagnosing ailments such as COVID-19 and tuberculosis, our models have the potential to transform care and treatment strategies, highlighting their role in clinical diagnostics.
Endoscopic Ultrasound-Guided Fine Needle Biopsy of Focal Liver Lesions: An Effective Mini-Invasive Alternative to the Percutaneous Approach
Authors: Rancatore Gabriele , Ligresti Dario , Rizzo Giacomo Emanuele Maria , Carrozza Lucio , Traina Mario , Tarantino Ilaria
Published: June 2024

Despite the introduction of serological neoplastic biomarkers and typical radiological characteristics in clinical practice, liver biopsy (LB) is often still necessary to establish a histological diagnosis, especially in ambiguous cases. Nowadays, LB via the percutaneous approach (PC-LB), under computed tomography (CT) scan or ultrasonography (US) guidance, is the route of choice. However, certain focal liver lesions can be challenging to access percutaneously. In such cases, endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) may represent an attractive, minimally invasive alternative. This retrospective observational study aimed to evaluate the efficacy, diagnostic performance, and safety of EUS-FNB conducted on 58 focal liver lesions located in both liver lobes. The adequacy of FNB samples for focal liver lesions located in the left and right lobes was 100% and 81.2%, respectively, and the difference was statistically significant (p = 0.001). Technical success was 100% for both liver lobes. The overall sensitivity and specificity were 95% and 100%, respectively. EUS-FNB is effective in making an accurate diagnosis with an excellent safety profile for focal liver lesions located in both liver lobes.
The Multifaceted Complexity of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS): A Case Report Highlighting Atypical Gastrointestinal Manifestations
Authors: Mancini Massimiliano , Di Nardo Giovanni , Casciani Emanuele , Feudi Maria , Bargiacchi Lavinia , Petraroli Angelica , Della Casa Francesca , Di Napoli Arianna , Vecchione Andrea
Published: June 2024

Background. Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) is an autosomal dominant autoinflammatory disorder stemming from mutations in the TNFRSF1A gene affecting the tumor necrosis factor receptor (TNFR)-1. These mutations lead to dysregulated inflammatory responses, primarily mediated by augmented interleukin (IL)-1β release. Case Presentation. We present the case of a 29-year-old woman with a history of recurrent febrile episodes, abdominal pain, and joint manifestations, eventually diagnosed with TRAPS following genetic testing revealing a heterozygous R92Q mutation in TNFRSF1A. Further genetic examinations unveiled additional clinically significant mutations, complicating the clinical picture. Our patient exhibited delayed colonic transit time and right colonic amyloidosis, a rare complication. Surgical intervention was required for overwhelming intestinal obstruction, revealing mucosal atrophy and dense lymphocytic infiltrates on histological examination. Discussion. Gastrointestinal involvement in TRAPS is common but can present diagnostic challenges. Following colon resection, histological examination revealed amyloid deposition, underscoring the importance of a comprehensive evaluation of these patients. Isolated colic amyloidosis has significant diagnostic and prognostic implications, warranting cautious monitoring and tailored management strategies. Treatment of TRAPS typically involves anti-inflammatory agents such as IL-1 inhibitors, with our patient experiencing clinical improvement on anakinra and canakinumab. Conclusion. This case report emphasizes the diverse manifestations of TRAPS and the importance of recognizing gastrointestinal complications, particularly isolated colic amyloidosis. Comprehensive evaluation, including histological examination, is crucial for identifying atypical disease presentations and guiding management decisions. Continued research is needed to elucidate the underlying mechanisms and optimize treatment strategies for TRAPS and its associated complications.