bluuebunny/crossref_metadata_2025 huggingface dataset:
CARACTERIZAÇÃO CLIMÁTICA DA SERRA DE MARTINS-RN
Authors: Medeiros Jacimária Fonseca de , Cestaro Luiz Antonio , Queiroz Larissa Silva
Published: November 2021

O Nordeste brasileiro em sua maior porção é definido por clima Semiárido. No entanto, ao analisar a região em escala cartográfica maior, é possível desvelar áreas que fogem a este contexto, caracterizando-se como Áreas de Exceção ou enclaves úmidos. Assim, esta pesquisa objetivou uma caracterização climática da Serra de Martins, no período de 1973 a 2002, comparando com o município de Antonio Martins, situado na Depressão Sertaneja. Quanto aos dados, os pluviométricos foram disponibilizados pela EMPARN e os de temperatura foram estimados em software, seguindo modelo de Cavalcanti e Silva (1994), denominado de Estima_T e que disponibiliza as médias, máximas e mínimas com base em dados de latitude, longitude e altitude. Após a tabulação dos dados, o balanço hídrico climatológico foi gerado, conforme modelo proposto por Thornthwaite e Mather (1955). Para Martins encontrou-se a média pluviométrica de 1230 mm e 23ºC como média térmica. Já Antonio Martins o valor médio de precipitação encontrado foi de 693 mm e sua média térmica é de 27ºC. A partir dos dados gerados no balanço hídrico, tem-se a seguinte tipologia  climática, B1w2A’ (Megatérmico Úmido com déficit hídrico no inverno e na primavera) para Martins e C1dA’ (Megatérmico Subúmido Seco com pequeno ou nenhum excedente hídrico) para Antonio Martins.
IMPACTOS AMBIENTAIS DA CARCINICULTURA EM AMBIENTES COSTEIROS:
Authors: Cavalcante de Oliveira Júnior Marcos Antonio , Rodrigues Gomes Érico , Cardoso Rocha Glairton
Published: November 2021

A carcinicultura tem apresentado elevado crescimento nas últimas décadas. No Brasil a maioria dos empreendimentos de criação de camarão ocorre em ambientes costeiros. Apresenta como objetivo identificar os principais impactos ambientais que a carcinicultura tem causado aos ambientes costeiros e através disso discutir sobre possíveis medidas de mitigação. Fez-se uso da pesquisa bibliográfica, verificou-se as produções acadêmicas publicadas em revistas científicas nacionais e internacionais entre os anos de 2015 a 2019 e que desenvolveram estudos acerca dos impactos ambientais da atividade da carcinicultura em ambientes costeiros. Utilizou-se a base de dados Google Acadêmico, como palavras-chave os termos em português “carcinicultura”, “impacto ambiental”, “degradação”. Inicialmente foram identificadas 504 produções acadêmicas entre monografias (teses, dissertações e trabalhos de conclusão de curso), além de artigos publicados em anais de eventos e revistas científicas. Foram excluídas monografias e inclusos somente trabalhos publicados em revistas científicas. Foram selecionados e analisados 21 artigos científicos que versavam sobre a proposta do estudo. Como resultado identificou-se 16 impactos ambientais causados pelo desenvolvimento da carcinicultura como: desmatamento e supressão das áreas de manguezais, contaminação de corpos hídricos, extinção de espécies pesqueiras e demais espécies da fauna costeira, intensificação do processo erosivo.
ANÁLISE PROSPECTIVA DE CORPOS MÁFICOS-ULTRAMÁFICOS ATRAVÉS DE AEROGEOFÍSICA: CASO DE ESTUDO DO VALE DO JACURICI/BAHIA
Authors: Pilla Dias João Rodrigo , Bertolini Gabriel , Charão Marques Juliana , Frantz José Carlos , Sobrinho da Silveira Carlos José , Cezario Natanael
Published: November 2021

Os corpos ígneos do Vale Jacurici hospedam o maior depósito de Cromo do Brasil. Esse depósito é caracterizado pela presença de uma camada maciça de minério que ocorrem em diversos corpos, segmentos de um possível corpo único fragmentado. O presente trabalho analisa as características desses corpos através de técnicas de sensoriamento remoto e levantamentos aerogeofísicos, descrevendo as respostas geofísicas e de relevo dos alvos econômicos. A área de estudo apresenta anomalias magnéticas quando utilizando-se filtros de 1ª derivada e tilt derivativo do campo magnético total, ao passo que razões eU/K e eTh/K definem as melhores delimitações dos corpos ígneos utilizando o método gamaespectrométrico. As informações apresentadas servem como parâmetro prospectivo na descoberta de novos corpos laterais a fim prover guia para a descoberta e análise de depósitos similares pelo Brasil.
Utrata urzędu proboszcza
Authors: WROCEŃSKI JÓZEF
Published: November 2021

Z urzędem proboszcza istotowo związana jest pasterska troska o powierzoną mu wspólnotę wiernych. Oznacza to, że do spełnienia swej misji został on powołany na podstawie uczestniczenia razem z biskupem w kapłaństwie Chrystusa i powierzonego sobie urzędu. Z tej racji proboszcz cieszy się w prawie określoną stabilnością, która ma na celu ścisłe i trwałe związanie go z powierzonym mu ludem, mobilizowanie go do ofiarnej i owocnej pracy duszpasterskiej. Jednakże stabilność ta nie ma charakteru bezwzględnego. Stąd też prawodawca kodeksowy zniósł urząd proboszcza nieusuwalnego, ponadto proboszcz swego urzędu nie sprawuje w sposób autonomiczny i bez żadnej zależności, lecz z upoważnienia biskupa diecezjalnego, który z mocy prawa Bożego jest pasterzem Kościoła partykularnego. Ze względu na dobro wiernych albo konieczność lub pożytek Kościoła albo też inne okoliczności życiowe tenże prawodawca przewiduje kilka sposobów utraty urzędu proboszcza. Na podstawie norm ogólnych urząd kościelny, w tym także urząd proboszcza, traci się po upływie czasu, po osiągnięciu określonego prawem wieku, na skutek rezygnacji, przeniesienia, usunięcia, a także pozbawienia. Naturalną przyczyną utraty każdego urzędu kościelnego jest śmierć osoby go piastującej. Pomimo tych postanowień prawodawca kościelny dla urzędu proboszcza odrębnie określa sposoby utraty, zaliczając do nich usunięcie lub przeniesienie dokonane zgodnie z przepisami prawa, zrzeczenie się dla słusznej przyczyny oraz upływ czasu. Szczególnie w przypadku usunięcia lub przeniesienia przewiduje specjalne procedury administracyjne. Chodzi nie o karne, lecz czysto administracyjne usunięcie lub przeniesienie proboszcza do innej parafii lub na inny urząd, ze względu na dobro wiernych. Wyodrębnienie tych dwóch procedur, które są znane w Kościele od dawna, wynika przede wszystkim z doniosłej roli, jaką w życiu wspólnoty parafialnej ma do spełnienia proboszcz oraz z faktu stałości jego urzędu. Procedury te mają na celu wyeliminowanie sytuacji, w której określone nadużycia ze strony proboszcza mogłyby pozbawić wiernych dóbr duchowych, do których mają prawo, nie pomijając też dobra proboszcza. Wszystkie sposoby utraty urzędu proboszcza, oprócz skutków szczegółowych określonych przez prawodawcę, powodują wakat parafii.
Spolupráce při správě majetku řeholního institutu na území místní církve
Authors: Menke Monika
Published: November 2021

Dokumenty Stolicy Apostolskiej z ostatniego okresu reflektują mocniej znaczenie odpowiedzialnego zarządzania majątkiem w instytutach zakonnych, zaś nadzór nad jego transparentnością i jego znaczenie zostały włączone nawet w sferze formacji zakonnej. Artykuł rekapituluje pozycję instytutów zakonnych w ramach Kościoła lokalnego, ich współpracę w zakresie zarządzania majątkiem oraz dotychczasowe kroki w zarządzaniu majątkiem zakonnym w RCz przez kilka pierwszych lat realizacji ustawy nr 428/2012 ZU o wyrównaniu majątkowym z Kościołami i związkami wyznaniowymi. Ustawa przewiduje restytucje naturalne oraz kompensacje finansowe. Pieniądze z rekompensat za niezwrócony majątek instytuty zakonne częściowo deponują, a część inwestują. Celem ma być przyszłe zupełne oddzielenie majątkowe Kościołów (a więc i zakonów) od państwa i umożliwienie samowystarczalności finansowej Kościołów.
Przekazywanie darowizny kościelnym osobom prawnym prowadzącym działalność charytatywno-opiekuńczą na rzecz zapobiegania, przeciwdziałania i zwalczania skutków epidemii COVID-19
Authors: Poniatowski Michał
Published: November 2021

W artykule przedstawiono problematykę darowizn dla kościelnych osób prawnych zajmujących się działalnością charytatywną na zapobieganie, przeciwdziałanie i zwalczanie skutków epidemii COVID-19.Punktem wyjścia było przedstawienie ogólnych podstaw darowizny. Następnie przedstawiono osobisty i merytoryczny aspekt darowizn przekazywanych na walkę z COVID-19. W tym zakresie podkreślono zmiany wprowadzone podczas epidemii. W artykule przedstawiono również praktyczne uwagi dotyczące umowy darowizny.Najważniejsze wnioski zostały przedstawione w podsumowaniu.
Odpowiedzialność odszkodowawcza w kanonicznym porządku prawnym. Próba teoretycznego uzasadnienia
Authors: Michowicz Przemysław
Published: November 2021

Założenia koncepcyjne pracy odwołują się do próby teoretycznego uzasadnienia odpowiedzialności odszkodowawczej w kanonicznym porządku prawnym. Czynią to w oparciu o reżim obowiązujących norm w przedmiocie problemu oraz przywołują treść niektórych orzeczeń trybunałów apostolskich w taki sposób, aby wyciągnięte wnioski z analizy dostępnego materiału pozwoliły na przyjęcie uzasadnienia odpowiedzialności naprawczej w pełnej zgodności ze specyfiką kanonicznego systemu prawnego. Wśród teorii stanowiących teoretyczne uzasadnienie konieczności naprawy powstałej szkody lub wyrządzonej krzywdy, optymalną propozycją jest model oparty na koncepcji sprawiedliwości konkretnego przypadku, bowiem czyni własnymi postulaty prawnego porządku Kościoła.
Microbial Cold Shock Proteins: Overview of their Function and Mechanism of Action
Authors: Zhang Yonghong , Bao Changjie , Shen Lijun , Tian Chunjie , Zang Xueli , Chen Guang , Zhang Sitong
Published: November 2021

:

The organism responds to a decrease in temperature by producing a series of cold shock
proteins (CSPs). These proteins play a critical role in growing and functioning characteristics at
low temperatures. CSPs have been discovered in a wide range of organisms and have shown enormous
diversity; their mechanisms of action are also complicated. Transcription and translation in
microorganisms typically occur via a single linear chain, but upon exposure to low temperatures,
RNA forms a complex secondary structure that prevents ribosomes from binding to it, thus slowing
down translation. CSPs bind to mRNA as RNA molecular chaperones to keep the mRNA secondary
structure in a single-stranded linear conformation, allowing successful translation at low
temperatures.
Oral Treatment with Angiotensin-(1-7) Attenuates the Kidney Injury
Induced by Gentamicin in Wistar Rats
Authors: Pacheco Lílian Fernanda , de Castro Carlos Henrique , Dutra João Batista Rodrigues , de Souza Lino Ruy , Ferreira Patrícia Maria , dos Santos Robson Augusto Souza , Ulhoa Cirano José
Published: November 2021

Background:

Acute Kidney Injury (AKI), a common disease of the urinary system, can
be induced by high doses of gentamicin (GM). The renin-angiotensin system exerts a key role in
the progression of the AKI since elevated intrarenal levels of Ang II, and ACE activity is found in
this condition. However, it is unknown whether oral administration of angiotensin (Ang)-(1-7), a
heptapeptide that evokes opposite effects of Ang II, may attenuate the renal injuries induced by gentamicin.

Objectives:

To evaluate the effects of Ang-(1-7) on GM-induced renal dysfunction in rats.

Methods:

AKI was induced by subcutaneous administration of GM (80 mg/Kg) for 5 days. Simultaneously,
Ang-(1-7) included in hydroxypropyl β-cyclodextrin (HPβCD) was administered by gavage
[46 μg/kg HPβCD + 30 μg/kg Ang-(1-7)]. At the end of the treatment period (sixth day), the
rats were housed in metabolic cages for renal function evaluation. Thereafter, blood and kidney
samples were collected.

Results:

Ang-(1-7) attenuated the increase of the plasmatic creatinine and proteinuria caused by
GM but did not change the glomerular filtration rate nor tubular necrosis. Ang-(1-7) attenuated the
increased urinary flow and the fractional excretion of H2O and potassium observed in GM rats but
intensified the elevated excretion of sodium in these animals. Morphological analysis showed that
Ang-(1-7) also reduced the tubular vacuolization in kidneys from GM rats.

Conclusion:

Ang-(1-7) promotes selective beneficial effects in renal injuries induced by GM.
Optimized Expression of Recombinant Human NIMA-Related Kinase 7
(NEK7) with A Higher Purity in Escherichia coli
Authors: Zhang Xing-Jie , Wang Ting-Ting , Pu Yu-Kun , Zeng Lin , Zhang Rui-Han , Li Xiao-Li , Ji Xu , Xiao Wei-Lie
Published: November 2021

Background:

NIMA (never in mitosis, gene A) serine/threonine kinase 7 (NEK7) is a
regulator of mitosis spindle in mammals and is considered as a drug target of inflammasome related
inflammatory diseases. However, most commercially available or reported recombinant NEK7
proteins are either inactive or have low purity. These shortcomings limit the pharmacological
studies and development of NEK7 inhibitors.

Objective:

To elucidate what causes the NEK7 low purity in E. coli, and optimize a protocol to improve
the protein purity.

Methods:

A comparative study of expression full length NEK7 with an N-terminal His-tag or a Cterminal
His-tag was performed. His-affinity resin, ion exchange and gel filtration chromatography
were used to purify NEK7. The protein was identified by mass spectrometry. The activity and folding
of NEK7 were evaluated by chemiluminescent assay and thermal shift assay.

Results:

Our results demonstrated that N-terminal tagged protein was toxic to E. coli, resulting in
incomplete translated products. The C-terminal tagged NEK7-His6 had a much higher purity than
that of an N-terminal tag. The Ni2+ resin one-step purification led to a purity of 91.7%, meeting the
criteria of most kinase assays. With two-step and three-step procedures, the protein purities were
94.7% and ~100%, respectively. The NEK7 purified in this work maintained its kinase activity and
correct conformation, and the compound-protein interaction ability.

Conclusion:

Our optimized protocol could produce good purity of His tagged NEK7 in E. coli, and
the kinase activity and biophysical characteristics of which are preserved.
Copper Complexes as Antitumor Agents:In vitroandIn vivoEvidence
Authors: Balsa Lucia M. , Baran Enrique J. , León Ignacio E.
Published: November 2021

:

Copper is an essential element for most aerobic organisms, with an important function as a structural and catalytic cofactor, and in consequence, it is implicated in several biological actions. The relevant aspects of chemistry and biochemistry and the importance of copper compounds in medicine give us a comprehensive knowledge of the multifaceted applications of copper in physiology and physiopathology. In this review, we present an outline of the chemistry, and the antitumor properties of copper complexes on breast, colon, and lung cancer cells focus on the role of copper in cancer, the relationship between structure-activity, molecular targets, and the study of the mechanism of action involved in its anticancer activity. This overview is expected to contribute to understanding the design, synthesis, and uses of copper complexes as antitumor agents in the most common cancers.
Multicomponent Approach for the Sustainable Syntheses of Pyrido[2,3-d]pyrimidine Scaffold
Authors: Chaudhary Ankita
Published: November 2021

Pyrido[2,3-d]pyrimidine is an N-fused heterocyclic compound formed by the ortho
fusion of pyridine and pyrimidine ring. Pyrido[2,3-d]pyrimidines hold a prominent position in
medicinal chemistry owing to their wide spectrum of biological activities like antiviral, antihistaminic,
antibacterial, diuretic, anti-inflammatory, analgesic, anticonvulsive, antipyretic,
etc. The extraordinary features of pyrido[2,3-d]pyrimidines make their synthesis a perpetual
field of research. Moreover, the construction of elaborate biologically relevant moieties via a
multicomponent approach has become a promising area of research, owing to the burgeoning
‘green chemistry drive’. Advances in the exploitation of proficient synthetic routes involving a
multicomponent approach for the assembly of this scaffold are reported in this review.
Unfolded p53 as a Marker of Oxidative Stress in Mild Cognitive Impairment, Alzheimer’s and Parkinson’s Disease
Authors: García Sara , Amor-Gutiérrez Olaya , Palomares-Albarrán María , Toyos-Rodríguez Celia , Cuetos Fernando , Martínez Carmen , Costa-García Agustín , Fernández-Sánchez Maria Teresa , de la Escosura-Muñiz Alfredo , Novelli Antonello
Published: November 2021

Aims:

There are several candidate biomarkers for AD and PD which differ in sensitivity,
specificity, cost-effectiveness, invasiveness, logistical and technical demands. This study is
aimed to test whether plasma concentration of unfolded p53 may help to discriminate among the
neurodegenerative processes occurring in Mild Cognitive Impairment, Alzheimer’s disease and
Parkinson’s disease.

Method:

An electrochemical immunosensor was used to measure unfolded p53 in plasma samples
of 20 Mild Cognitive Impairment (13 males/7 females; mean age 74.95±5.31), 20 Alzheimer’s (11
males/9 females; mean age: 77.25±7.79), 15 Parkinson’s disease patients (12 males/3 females;
mean age: 68.60 ± 7.36) and its respective age/sex/studies-matched controls.

Result:

We observed a significantly higher concentration of unfolded p53 in the plasma of patients
of each of the three pathologies with respect to their control groups (p=0.000). Furthermore,
the plasma concentration of unfolded p53 was significantly higher in Alzheimer’s disease patients
in comparison with Mild Cognitive Impairment patients (p=0.000) and Parkinson’s disease patients
(p=0.006). No significant difference between Mild Cognitive Impairment and Parkinson’s disease
patients was observed (p=0.524).

Conclusion:

Our results suggest that unfolded p53 concentration in the plasma may be a useful biomarker
for an undergoing neuropathological process that may be common, albeit with different intensity,
to different diseases.
Neuroprotective Effect of Fucoxanthin against Intracerebroventricular Streptozotocin (ICV-STZ) Induced Cognitive Impairment in Experimental Rats
Authors: Dhami Mahadev , Raj Khadga , Singh Shamsher
Published: November 2021

Background:

Alzheimer's disease (AD) is a neurological disorder characterized by loss of memory and cognitive functions caused by oxidative stress, neuroinflammation, change in neurotransmitter levels, and excessive deposition of Aβ(1-42)plaques. Fucoxanthin is a carotenoid with potential antioxidant, anti-inflammatory, and neuroprotective actions.

Objective:

In the present study, fucoxanthin was employed as a protective strategy in Intracerebroventricular Streptozotocin (ICV-STZ) induced experimental model of cognitive impairment.

Methods:

STZ was injected twice ICV (3 mg/kg) on alternate days 1 and 3, and Wistar rats were evaluated for the memory analysis using Morris water maze and elevated plus-maze. Fucoxanthin at low 50 mg/kg, p.o. and high dose 100 mg/kg, p.o. was administered for 14 days. All animals were sacrificed on day 29, and brain hippocampus tissue after isolation was used for biochemical (MDA, nitrite, GSH, SOD and Catalase), neuroinflammatory (TNF-α, IL-1β, and IL-6), neurotransmitters (ACh, GABA Glutamate), Aβ(1-42)and Tau protein measurements.

Results:

STZ-infused rats showed significant impairment in learning and memory, increased oxidative stress (MDA, nitrite), reduced antioxidant defense (GSH, SOD and Catalase), promoted cytokine release, and change in neurotransmitters level. However, fucoxanthin improved cognitive functions, restored antioxidant levels, reduced inflammatory markers dose-dependently, and restored neurotransmitters concentration.

Conclusion:

The finding of the current study suggests that fucoxanthin could be the promising compound for improving cognitive functions through antioxidant, anti-inflammatory, and neuroprotective mechanisms, and inhibition of acetylcholinesterase (AChE) enzyme activities, Aβ(1-42)accumulation, and tau protein.
Advancement and Strategies for the Development of Peptide-drug Conjugates:
Pharmacokinetic Modulation, Role and Clinical Evidence against
Cancer Management
Authors: Malviya Rishabha , Verma Swati , Sundram Sonali
Published: November 2021

:

Currently, many new treatment strategies are being used for the management of cancer.
Among them, chemotherapy based on peptides has been of great interest due to the unique features
of peptides. This review discusses the role of peptide and peptides analogues in the treatment of
cancer, with special emphasis on their pharmacokinetic modulation and research progress. Low
molecular weight, targeted drug delivery, enhanced permeability, etc., of the peptide-linked drug
conjugates, lead to an increase in the effectiveness of cancer therapy. Various peptides have recently
been developed as drugs and vaccines with an altered pharmacokinetic parameter which has subsequently
been assessed in different phases of the clinical study. Peptides have made a great impact
in the area of cancer therapy and diagnosis. Targeted chemotherapy and drug delivery techniques
using peptides are emerging as excellent tools in minimizing problems with conventional chemotherapy.
It can be concluded that new advances in using peptides to treat different types of cancer
have been shown by different clinical studies indicating that peptides could be used as an ideal
therapeutic method in treating cancer due to the novel advantages of peptides. The development of
identifying and synthesizing novel peptides could provide a promising choice to patients with cancer.
Efficacy and Safety of Pidotimod in Childhood Wheezing: A Pilot Study
Authors: Manti Sara , Parisi Giuseppe Fabio , Papale Maria , Mollica Federico , Giugno Andrea , Leonardi Salvatore
Published: November 2021

Background:

There is a growing need for effective therapies for the management of
wheezing in the pediatric population.

Aim:

We conducted a pilot, mono-centre, prospective, follow-up study to assess the efficacy and
the safety of Pidotimod (PDT) in the treatment of wheezing in children.

Methods:

Globally, 90 children (M:F=58:62, mean age 4.7±1.64 years) with recurrent viral wheezing
were enrolled in the study between October-November 2018. At baseline, children received
treatment with PDT as 1 vial of 400mg daily for 3 consecutive months. We evaluated the therapeutic
efficacy of PDT treatment at the end of 3 (T3) months of therapy as well as the long efficacy
and preventive efficacy of PDT treatment during a 3-months follow-up (T6) by using the following
outcomes: (i) How many patients showed one or more episodes of viral wheezing? (ii) How many
patients were taking concomitant medications (ICS, SABA, antibiotics)? (iii) How many patients
required ED visits? (iv) How many patients required hospitalization?

Results:

A significant decrease in the number of patients with at least one or more episodes of
wheezing and taking antibiotics was recorded after 3 months of treatment, and a further significant
decrease for both outcomes was reported at 3-months follow-up period (p<0.05). Differently, after
3 months of treatment, we found a significant decrease in the number of patients taking ICS and
SABA and in the number of patients requiring ED visits and/or hospitalization (p<0.05); however,
for all these outcomes, no further significant decrease was reported at follow-up period.

Conclusion:

We first showed that the administration of PDT is useful in the management of patients
with recurrent viral wheezing because we found a reduction in the number of patients requiring
ED visits and/or hospitalization as well as the number of patients taking drugs during the treatment
period. Moreover, to date, we found a long-term clinical effect over three months after treatment
suspension counteracting the recurrence of the disease.
Application of Silver Nanoparticles as a New Alternative Antiviral Agent
for SARS-CoV-2: A Review
Authors: Jamunkar Reena , Shrivas Kamlesh , Sinha Deepak , Patel Sanyukta , Monisha  , Patle Alka , Kumar Antresh , Banerjee Subhash
Published: November 2021

Background:

Today, SARS-CoV-2 (COVID-19), a viral disease caused by the novel
coronavirus (a tiny crowned virus), has become one of the threats for human beings all over the
world and caused the death of millions of people worldwide. Many vaccines have been developed
and administered to people in several countries; however, due to their propensity to create new
strains, it appears that curing all corona strains will be challenging. So, it is necessary to identify the
structure of the virus, mechanism of action, and its antiviral activities against drugs and other functional
materials.

Method:

AgNPs have unique physicochemical and antimicrobial properties. This review describes
the structure and nature of the virus and the mechanism of action of an antiviral drug such as silver
nanoparticles (AgNPs) with the virus. In addition, different methods for synthesis of AgNPs, application
of AgNPs as an antiviral agent against influenza virus, human immuno deficiency virus
(HIV), herpes simplex virus type 1 (HSV-1), hepatitis B virus (HBV), polio virus, respiratory syncytial
virus (RSV), are discussed. Also, the most probable applications and properties of AgNPs that
can help prepare it as an antiviral agent are discussed.

Results:

The use of AgNPs against various viruses, including the coronavirus family, is found to be
effective; therefore, it can be considered for the development of antiviral agents, disinfectants, antiviral
coated mask, and their therapeutic use against the treatment of novel coronavirus with minimum
side effect and great efficiency.

Conclusions:

AgNPs were successfully used for the treatment of various viral diseases of the coronavirus
family such as H1N1, H3N2, influenza, even for SARS and MERS coronaviruses. AgNPs
coated masks, disinfectants, fabrics, wipes, and inhalation systems are effective for the inhibition of
SARS-CoV-2 infection. Since sanitizers have a temporary effect, the development of some other
potential alternatives having low toxicity, ease of use, long lasting efficiency, health cautiousness,
minimum side effect, sustainable fabrics is required.
The use of interactive methods in teaching professional speech to students
Authors: Mukaddas Akhmedova , Nilufar Dilmurodova
Published: November 2021

Interactive teaching methods provide solutions to educational problems in various aspects. The use of interactive methods allows you to organize independent cognitive activity of students during the lesson. Possession of interactive learning technology and its use in the educational process will undoubtedly contribute to the development of students' qualities that correspond to the processes taking place in life today. This paper presents the technologies of conducting Uzbek language lessons using interactive methods and their significance.
Ética militar y fundamentación profesional. Evolución, conceptos y principios
Authors: Ardila-Castro Carlos Alberto , Sierra-Zamora Paola Alexandra , Whetham David
Published: November 2021

Esta obra hace una valiosa contribución a la comprensión de la ética militar, como un elemento central de la carrera militar en Colombia, y destaca la necesidad de que fundamente en todo momento el cumplimiento de la misión constitucional que tienen las instituciones castrenses en el país. A través de tres volúmenes, se describen y analizan críticamente los fundamentos teóricos de la ética que orientan las reflexiones y el quehacer cotidiano de los miembros de las Fuerzas Militares, desde su proceso educativo en las escuelas de formación, hasta los distintos niveles y espacios operacionales en los que se desempeñan. Además, se analizan estudios de caso específicos de aplicación de la ética militar relacionados tanto con escenarios tradicionales, como con los nuevos contextos, caracterizados por los avances tecnológicos, las transformaciones de los actores delictivos, los cambios en las relaciones internacionales, las condiciones particulares de Colombia, entre otros aspectos. En este primer volumen se establecen las bases teóricas y conceptuales necesarias para el estudio de la ética militar. Específicamente, se abordan seis temas principales: el jus ad bellum, jus in bello, jus ex bello y jus post bellum; reflexiones teóricas en torno a la filosofía moral, la cultura y la educación; la familia; la corrupción; la toma de decisiones y el planeamiento operacional, y la estrategia. De esta forma, el libro enfatiza la importancia de fortalecer constantemente la ética miliar en Colombia para garantizar a largo plazo el correcto desarrollo de la carrera militar y el bienestar para los habitantes del país.
Hubungan Kualitas Hidup dan Psychological Well-Being pada Anggota Keluarga yang Menjadi Caregiver Pasien Kanker di Kota Bandung
Authors: Lestari Arinurasti Rahma , Nurhayati Siti Rohmah
Published: November 2021

Penyakit kanker merupakan penyebab utama kematian di dunia. Dalam banyak kasus, pasien kanker tidak hanya berjuang sendiri untuk penyembuhan, tetapi juga didampingi oleh anggota keluarga yang menjadi caregiver. Ada sebagian caregiver yang kesulitan untuk mewujudkan kualitas hidup dan psychological well-being yang baik. Oleh karena itu, penelitian ini bertujuan untuk mengetahui keadaan dan hubungan antara kualitas hidup dengan psychological wellbeing pada anggota keluarga yang menjadi caregiver pasien kanker. Penelitian ini menggunakan pendekatankuantitatif dengan jenis penelitian korelasional. Penelitian dilakukan di Rumah Singgah Sehat Sejahtera dan Rumah Singgah Kasih yang berada di kota Bandung. Subjek penelitian berjumlah 112 orang dengan menggunakan teknik pengambilan sampel accidental sampling. Alat pegumpulan data menggunakan Skala Kualitas Hidup dan SkalaPsychological Well-being. Reliabilitas dalam skala penelitian ini menggunakan koefisien reliabilitas Alpha Cronbach sebesar 0,893 (α=0,893) pada skala kualitas hidup dan 0,938 (α=0,938) pada sekala psychological well-being. Data dalam penelitian ini dianalisis menggunakan teknik korelasi product moment dari Pearson. Koefisien korelasi yangdiperoleh sebesar 0,619 dengan probabilitas 0,000 (p < 0,01). Hasil penelitian menunjukkan bahwa kualitas hidup dan psychological well-being memiliki hubungan yang positif. Hal ini berarti semakin tinggi tingkat kualitas hidup caregiver maka tingkat psychological wellbeing akan semakin tinggi.
Relasi antara Orang tua dan Anak Ditinjau dari Sudut Pandang Remaja dengan Perilaku Delinkuen
Authors: Sari Nourmarifa
Published: November 2021

Penelitian ini bertujuan untuk mengetahui relasi antara orang tua dan anak menurut sudut pandang remaja yang memiliki perilaku delinkuen. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologis. Responden penelitian ini adalah 2 orang remaja laki-laki berusia 16-20 tahun yang memiliki skor skala delinkuensi ≥17. Skala delinkuensi yang digunakan dalam penelitian yaitu Skala Delinkuensi Theunnisen yang telah dialih bahasa dan disesuaikan kembali dengan konteks di Indonesia. Hasil penelitian menunjukkan bahwa relasi menurut remaja yang memiliki perilaku delinkuen adalah adanya relasi yang bersifat positif dan negatif. Relasi yang bersifat positif di antaranya pengasuhan, transmisi nilai, kedekatan, perhatian, dan kebersamaan. Relasi yang bersifat negatif di antaranya adalah kurangnya dukungan, minimnya pemahaman, kesalahan komunikasi antara orang tua dan anak, juga adanya konflik yang tidak disertai dengan manajemen konflik yang baik
Hubungan antara Intensitas Penggunaan Media Sosial dan Prokrastinasi Akademik dalam Menyelesaikan Skripsi pada Mahasiswa
Authors: Neidi Arrazzaqu Widya
Published: November 2021

Intensitas penggunaan media sosial ternyata dapat menimbulkan dampak negative pada penyelesaian skripsi mahasiswa. Intensitas yang tinggi ditengarai menjadi salah satu penyebab terjadinya prokrastinasi akademik dalam menyelesaikan skripsi. Namun sayangnya hubungan antara dua variable tersebut belum banyak diteliti. Tujuan penelitian ini yaitu untuk mengetahui hubungan positif antara intensitas penggunaan media sosial dan perilaku prokrastinasi akademik pada mahasiswa yang sedang menyelesaikan skripsi. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian korelasional. Subjek penelitian ini adalah 68 orang mahasiswa Fakultas Ilmu Pendidikan Universitas Negeri Yogyakarta dengan menggunakan teknik pengambilan sampel simple random sampling. Teknik pengumpulan data yang digunakan terdiri dari skala intensitas penggunaan media sosial dan skala prokrastinasi akademik. Reliabilitas skala intensitas penggunaan media sosial dan skala prokrastinasi akademik diuji dengan menggunakan metode koefisien reliabilitas Alpha Cronbach. Reliabilitas untuk skala intensitas penggunaan media sosial memperoleh hasil sebesar 0.862, sedangkan skala prokrastinasi akademik memperoleh hasil 0.785. Data dalam penelitian ini dianalisis dengan teknik korelasi product moment dari Pearson. Koefisien korelasi yang diperoleh 0.421 dengan signifikansi (p) < 0,01 dan koefisiensi determinasi sebesar (R2) 17.7%. Hasil penelitian ini menunjukkan bahwa terdapat hubungan positif antara intensitas penggunan media sosial dan prokrastinasi akademik. Hal ini berarti semakin tinggi intensitas penggunaan media sosial, maka diikuti pula semakin tingginya perilaku prokrastinasi akademik pada mahasiswa yang sedang menyelesaikan skripsi.
Pengaruh Self-efficacy terhadap Komitmen Organisasi pada Karyawan The Rich Jogja Hotel
Authors: Dewi Nira Avie Dyah Puspita
Published: November 2021

Penelitian ini bertujuan untuk mengkaji mengenai pengaruh self-efficacy terhadap komitmen organisasi pada karyawan The Rich Jogja Hotel. Penelitian ini menggunakan pendekatan kuantitatif dan merupakan penelitian ex- post facto. Subjek yang terlibat pada penelitian ini merupakan karyawan tetap The Rich Jogja Hotel yang berjumlah 111 orang. Instrumen penelitian menggunakan Skala Komitmen Organisasi dan Skala Self-efficacy. Seleksi item dalam penelitian ini menggunakan Corrected Item Total Correlation dengan angka korelasi antara 0,273-0,829. Uji reliabilitias yang digunakan adalah uji Cronbach Alpha dengan hasil koefisiensi pada variabel komitmen organisasi sebesar 0,777 dan koefisiensi variabel self-efficacy sebesar 0,899. Berdasarkan hasil analisis regresi sederhana, didapatkan hasil bahwa self-efficacy berpengaruh positif terhadap komitmen organisasi, dengan nilai F hitung= 28,134 > F tabel dengan nilai R2= 0,205 atau 20,5%.
Acceptability of an mHealth App for Youth With Substance Use and Mental Health Needs: Iterative, Mixed Methods Design
Authors: Adams Zachary , Grant Miyah , Hupp Samantha , Scott Taylor , Feagans Amanda , Phillips Meredith Lois , Bixler Kristina , Nallam Phani Teja , La Putt Dorothy
Published: November 2021

Background

Treating substance use disorders (SUDs) during adolescence can prevent adult addiction and improve youth outcomes. However, it can be challenging to keep adolescents with SUDs engaged in ongoing services, thus limiting potential benefits. Developmentally appropriate tools are needed to improve treatment engagement during and between sessions for youth with SUDs and mental health disorders. Mobile health apps may augment or replace psychotherapy components; however, few have been developed specifically for youth with SUDs following user-guided design principles, which may limit their appropriateness and utility. Formative research on acceptability to intended end users is needed before the efficacy of such tools can be examined.

Objective

This study involves user-centered, iterative development and initial user testing of a web-based app for adolescents with SUDs and mental health concerns.

Methods

Adolescents aged 14 to 17 years with past-year involvement in outpatient psychotherapy and behavioral health clinicians with adolescent SUD treatment caseloads were recruited. Across 2 assessment phases, 40 participants (alpha: 10 youths and 10 clinicians; beta: 10 youths and 10 clinicians) viewed an app demonstration and completed semistructured interviews and questionnaires about app content and functionality.

Results

Participants expressed positive impressions of the app and its potential utility in augmenting outpatient therapy for youth with SUDs and mental health concerns. Noted strengths included valuable educational content, useful embedded resources, and a variety of activities. Adolescents and clinicians favored the app over conventional (paper-and-pencil) modalities, citing convenience and familiarity. The app was found to be user-friendly and likely to improve treatment engagement. Adolescents suggested the inclusion of privacy settings, and clinicians recommended more detailed instructions and simplified language.

Conclusions

The novel app developed here appears to be a promising, acceptable, and highly scalable resource to support adolescents with SUDs and mental health concerns. Future studies should test the efficacy of such apps in enhancing adolescent behavioral health treatment engagement and outcomes.
Comparison of Altmetrics with Conventional Bibliometrics in the Surgical Literature (Preprint)
Authors: Thyarala Shashank , Flaherty Gerard
Published: November 2021

BACKGROUND

The impact of a research publication has traditionally been quantified by its citation count. Newer bibliometric indices such as Altmetric Attention Score (AAS) and article page views are emerging as supplementary measures to quantify the academic influence of research.

OBJECTIVE

The aim of the current study was to interrogate the relationship between novel and traditional bibliometric indices for research published in a leading surgical journal and evaluate the role of these newer indices in measuring the impact of surgical research.

METHODS

All articles published in JAMA Surgery between 1 January 2019 and 1 September 2021 were examined. The literature database PubMed was used to identify all articles published within the specified time period. The cumulative citation count, AAS, and article page views were retrieved from the journal website. Statistical analysis using the Pearson rank correlation coefficient (r) was performed on Minitab 19.

RESULTS

: A total of 1,071 articles were retrieved for further analysis. The correlation (95% CI) between ranks for all articles was 0.396 (0.344-0.445) for AAS and citation scores, 0.541 (0.497-0.582) for citations and article page views, and 0.413 (0.362-0.461) for AAS and article page views.

CONCLUSIONS

We demonstrated a medium correlation between citations and AAS for articles published in a leading surgical journal. The inter-year correlation between 2019 and 2021 was similar, suggesting that AAS could be predictive of future citations. AAS may be useful in evaluating the wider societal impact of the surgical literature and could serve to promote greater public engagement in surgical research.
An Augmented Reality Technology to Provide Demonstrative Inhaler Technique Education for Patients With Asthma: Interview Study Among Patients, Health Professionals, and Key Community Stakeholders (Preprint)
Authors: O'Connor Antonia , Sharrad Kelsey , King Charmaine , Carson-Chahhoud Kristin
Published: November 2021

BACKGROUND

Many people with asthma use incorrect inhaler technique, resulting in suboptimal disease management and increased health service use. Novel ways of delivering appropriate instructions are needed.

OBJECTIVE

This study explored stakeholder perspectives on the potential use of augmented reality (AR) technology to improve asthma inhaler technique education.

METHODS

On the basis of existing evidence and resources, an information poster displaying the images of 22 asthma inhaler devices was developed. Using AR technology via a free smartphone app, the poster launched video demonstrations of correct inhaler technique for each device. In total, 21 semistructured, one‐on‐one interviews with health professionals, people with asthma, and key community stakeholders were conducted, and data were analyzed thematically using the Triandis model of interpersonal behavior.

RESULTS

A total of 21 participants were recruited into the study, and data saturation was achieved. People with asthma were confident with inhaler technique (mean score 9.17, SD 1.33, out of 10). However, health professionals and key community stakeholders identified that this perception was misguided (mean 7.25, SD 1.39, and mean 4.5, SD 0.71, for health professionals and key community stakeholders, respectively) and facilitates persistent incorrect inhaler use and suboptimal disease management. Delivering inhaler technique education using AR was favored by all participants (21/21, 100%), particularly around ease of use, with the ability to visually display inhaler techniques for each device. There was a strongly held belief that the technology has the capacity for improving inhaler technique across all participant groups (mean 9.25, SD 0.89, for participants; mean 9.83, SD 0.41, for health professionals; and mean 9.5, SD 0.71, for key community stakeholders). However, all participants (21/21, 100%) identified some barriers, particularly regarding access and appropriateness of AR for older people.

CONCLUSIONS

AR technology may be a novel means to address poor inhaler technique among certain cohorts of patients with asthma and serve as a prompt for health professionals to initiate review of inhaler devices. A randomized controlled trial design is needed to evaluate the efficacy of this technology for use in the clinical care setting.
Opportunity Cost and Automated Behavior in Groups
Authors: Zhao Mengyue
Published: November 2021

What you are giving up may be what others are holding on to, and what you are holding on to may be what others are giving up. This paper revolves around the relationship between opportunity cost and automated behavior and its application to groups.
Are eSports more than just sitting? A study comparing energy expenditure
Authors: Kocak Umut Ziya
Published: November 2021

Aim:
To investigate the energy expenditure of amateur eSport athletes between sitting and an eSport gaming session.
Materials & methods:
Eleven amateur male eSport athletes (age: 21.73 ± 3.50 years, weight: 76.00 ± 12.51 kg, height: 1.81 ± 0.06 m) were included. After recording the resting values, eSports playing values were recorded using an open circulation oxygen consumption analyzer (QuarkCPET, COSMED, Albano Laziale, Italy). Also, action per min (APM) scores were recorded.
Results:
When comparing the respiratory frequency, metabolic equivalent of task values and energy expenditure values of the participants, a significant increase was observed in all three values (p < 0.05 for each).
Conclusion:
eSports players, who are considered to be physically inactive by sitting, spend approximately 40% more energy than sitting, even at the amateur level. According to APM, more energy can be spent in tournaments and at the elite level.
КАК ПОВЫСИТЬ КПД СИЛОВЫХ МОДУЛЕЙ И СНИЗИТЬ ИХ МАССОГАБАРИТНЫЕ ПОКАЗАТЕЛИ? СОВРЕМЕННЫЕ МАТЕРИАЛЫ И МОНТАЖ КРИСТАЛЛОВ ПО ТЕХНОЛОГИИ "СИНТЕРИНГ" ДЛЯ ПРОИЗВОДСТВА ЭЛЕМЕНТОВ И МОДУЛЕЙ СИЛОВОЙ ЭЛЕКТРОНИКИ
Authors: Иванов В.И.
Published: November 2021

Материалы с широкой запрещенной зоной (WBG - Wide Band Gap), такие как нитрид галлия (GaN) и карбид кремния (SiC), уже исследованы и применяются рядом производителей для уменьшения размеров элементов и повышения эффективности преобразования энергии для силовой электроники. Но материал для монтажа кристаллов на диэлектрическую подложку также играет существенную роль, поэтому мы обсудим спекание (синтеринг, от англ. sintering) серебра (Ag).
ПЕРСПЕКТИВЫ РАЗВИТИЯ ТЕХНОЛОГИИ 3D-МИКРОСБОРОК ДЛЯ АППАРАТУРЫ КОСМИЧЕСКОГО ПРИМЕНЕНИЯ
Authors: Новоселов А.Ю.
Published: November 2021

ассмотрены параметры и конструктивные особенности систем в корпусе, разработанных на основе технологии 3D-монтажа, - схем памяти для аппаратуры космического применения. Предложены структура и схемотехника микросборки бортового компьютера на основе конструктива и технологии гибридного монтажа 3D-структур и отдельных кристаллов, включая CPLD (Complex Programmable Logic Device). Рассмотрен альтернативный принцип конструирования ячейки памяти, специализированной для применения в CPLD-микросхемах. Показаны результаты проектирования CPLD средней емкости для приборов космического применения. В качестве ключевой технологической базы использовался техпроцесс SOI 180 нм HV, 3D-структуры созданы с использованием TSV (Through-silicon via) интерпозеров (Interposer).
СЕРИЯ МИКРОСХЕМ СТАТИЧЕСКОЙ ПАМЯТИ 16, 32 И 64 МБИТ ОТЕЧЕСТВЕННОГО ПРОИЗВОДСТВА
Authors: Иванов С.А. , Игнатьев С.М. , Мещанов В.Д. , Рыбалко Е.С. , Шелепин Н.А.
Published: November 2021

Представлены результаты освоения производства в АО «Микрон» ряда однокристальных микросхем 90 нм КМОП синхронных статических ОЗУ информационной емкостью 16 и 32 Мбит и многокристальных модулей информационной емкостью 32 и 64 Мбит серий 1663 и 9013 с временем выборки адреса не более 10-18 нс.
АНАЛИЗ ВОЗМОЖНОСТЕЙ ПЛАТФОРМЫ DELTA DESIGN ДЛЯ ПРОЕКТИРОВАНИЯ ИНТЕГРАЛЬНЫХ МИКРОСХЕМ
Authors: Рыбкин С.В.
Published: November 2021

На основе анализа возможностей платформы Delta Design дается оценка развития САПР для проектирования ИМС различной сложности с учетом их технологических процессов. Открытое API и большой задел в аналоговом и цифровом моделировании, поддержка синтеза для некоторых ПЛИС предоставляют большие возможности для создания САПР под микроэлектронику.
ОБЗОР СКВОЗНОГО СПЕЦИАЛИЗИРОВАННОГО МАРШРУТА ПРОЕКТИРОВАНИЯ ВЫСОКОПЛОТНЫХ СИСТЕМ В КОРПУСЕ НА БАЗЕ РЕШЕНИЙ SIEMENS EDA (EX. MENTOR GRAPHICS)
Authors: Филиппов А.А.
Published: November 2021

Представлен обзор средств САПР Siemens EDA, успешно применяемых в решении задачи проектирования высокоплотных систем в корпусе.
ИССЛЕДОВАНИЕ ЧУВСТВИТЕЛЬНОЙ ОБЛАСТИ КНИ МОП-ТРАНЗИСТОРА К ВОЗДЕЙСТВИЮ ВТОРИЧНЫХ ЧАСТИЦ, ВОЗНИКАЮЩИХ ВСЛЕДСТВИЕ ОБЛУЧЕНИЯ НЕЙТРОНАМИ
Authors: Чистяков М.Г. , Глушко А.А. , Морозов С.А.
Published: November 2021

Исследована зависимость возникновения сбоев ячейки статической оперативной памяти от координаты возникновения вторичной частицы в результате воздействия нейтронного облучения. Предложен метод анализа накопленных зарядов для оценки сбоеустойчивости ячейки статической оперативной памяти в зависимости от координаты возникновения вторичной частицы и критического заряда, соответствующего статическому запасу помехоустойчивости. Анализ проводился на основе результатов приборно-технологического моделирования одиночного МОП-транзистора, входящего в состав ячейки статической оперативной памяти, и интегрирования полученных значений токовых откликов.
НАУЧНО-ТЕХНИЧЕСКИЕ АСПЕКТЫ ИСПЫТАНИЙ ТВЕРДОТЕЛЬНЫХ УСИЛИТЕЛЕЙ МОЩНОСТИ С РАБОЧИМИ ЧАСТОТАМИ ДО 40 ГГЦ
Authors: Амбуркин К.М. , Кузнецов А.Г. , Шеремета И.М.
Published: November 2021

Представлены научно-технические аспекты испытаний GaAs pHEMT-усилителей мощности с частотами до 40 ГГц, обобщены показатели чувствительности к импульсному воздействию ионизирующего излучения.
ВОЗМОЖНОСТИ И ПЕРСПЕКТИВЫ КОНТРАКТНОЙ РАЗРАБОТКИ И ПРОИЗВОДСТВА КРЕМНИЕВОЙ МИКРОЭЛЕКТРОНИКИ НА РОССИЙСКОЙ ПОЛУПРОВОДНИКОВОЙ ФАБРИКЕ
Authors: Шелепин Н.А. , Игнатов П.В. , Лукошко Г.К. , Шипицин Д.С.
Published: November 2021

В статье описываются возможности и перспективы контрактной разработки и производства кремниевой микроэлектроники на российской полупроводниковой фабрике, включая описание внедренных базовых технологических процессов и средств проектирования, а также порядок взаимодействия АО «НИИМЭ» и разработчиков микросхем при выполнении заказов на разработку и изготовление пластин с кристаллами заказанных элементов.