bluuebunny/crossref_metadata_2025 huggingface dataset:
Medium-to-Long-Term Success Rate of Left Atrial Appendage Closure Using Endocardial Sutures and Postoperative Anticoagulant Strategies
Authors: Heng Wenzhong , Song Hongying , Zhang Rong , Zhou Shibo , Huang Maoxun , Wang Yong , Wu Huiying , Wang Tiance
Published: December 2024

Background
Surgical endocardial closure of the left atrial appendage (LAA) is reported to reduce the risk of stroke in patients with atrial fibrillation (AF). This retrospective study assessed the efficacy and safety of endocardial suture obliteration with medium-to-long-term follow-up.
Methods
A total of 50 patients with valvular diseases and AF, treated from 2013 to 2018, were included in the analysis. All underwent heart valve surgery, the Cox-Maze IV procedure, and LAA closure using the endocardial suture obliteration technique. Intraoperative transesophageal echocardiography (TEE) was performed to assess the LAA closure outcomes. Closure failure was defined as a remnant LAA (> 1 cm) or persistent flow between the left atrium (LA) and LAA. Patients were followed up for an average of 7.16 ± 1.73 years, with transthoracic echocardiography (TTE) and TEE used to assess the results.
Results
Intraoperative TEE revealed no remnants of the LAA or persistent flow in any patient post-closure. None of those monitored postoperatively with TEE exhibited a remnant LAA > 1 cm; however, 5 (10%) patients had persistent flow between the LA and LAA. Of these five patients with closure failure, four (75%) presented with thrombus in the LAA stump, and one experienced a stroke event.
Conclusion
Our center has widely adopted the intraoperative closure of the LAA due to its simplicity, minimal bleeding risk, cost-effectiveness, and high success rate. For patients with confirmed LAA closure based on TEE evaluation, continued use of anticoagulant drugs may not be necessary.
Advanced Practice Nurses for Fall Incidence prevenTion in robust very old adults: protocol for the APN-FIT hybrid randomized controlled trial
Authors: Huet Jeremie , Rat Cédric , Renaux Carine , Mayol Séverine , Costanza Sarah , Riche Valérie-Pierre , Deschamps Thibault , Caillet Pascal , de Decker Laure
Published: December 2024

Background
Falls in older adults represent a major cause of disability and a pivotal indicator of the transition from robustness to frailty. Despite their proven effectiveness, the implementation of large-scale prevention programs has proved challenging, requiring the mobilization of extensive skills and human resources. In France, the role of Advanced Practice Nurses (APN) is becoming increasingly prominent, given their multimodal approach and nursing expertise, along with their clinical expertise.
Methods
This study is a hybrid, type 1, multicenter, randomized, open-label, superiority trial conducted in seven medical centers in the Pays de la Loire region in France. The primary objective is to assess the effect of a 12-month personalized multimodal follow-up by APNs on the incidence of falls in non-frail patients (Clinical Frailty Scale ≤ 3) aged over 80. Furthermore, a mixed ancillary study focusing on the intervention implementation will be conducted, and a cost-utility analysis will be performed. All 386 participants will be enrolled by APNs during an initial comprehensive geriatric assessment (CGA) and will be eligible to participate in a tailored home-based physical activity program. The intervention group will be followed by the APN 1, 3, 6, 9 and 12 months after inclusion. Primary and secondary outcomes, including those relating to intrinsic capacity domains, will be assessed in all participants during a second CGA at M12.
Discussion
In addition to a reduction in the incidence of falls, we expect that APNs will reduce the number of patients progressing to pre-frailty, frailty and impaired mobility. This study stands out for its hybrid design and the comprehensiveness of the geriatric assessment for assessing outcomes. The inclusion of 386 participants may be challenging and the retrospective collection of data on falls may be subject to memory biases. However, the results are likely to improve knowledge of the effect of APN follow-up in older adults and to optimize the implementation of APN-driven fall prevention programs in real-life situations.
Trial registration
This study has been registered on clinicaltrials.gov, NCT06617806, registration date 2024-09-26.
Dynamic alterations of novel thrombotic molecular markers in acute ischemic stroke patients after intravenous thrombolysis: a retrospective cohort study
Authors: Sun Wei , Xie Shuhua , Liu Fugan , Xie Yuqing , zhu Yunhui , Wu Pengcheng , Zhu Jiajia , Liu Xianghong
Published: December 2024

Background:
Novel thrombotic molecular markers include the thrombin-antithrombin complex (TAT), plasmin inhibitor-plasmin complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-plasminogen activator inhibitor-1 complex (t-PAIC). These molecular markers facilitate the early assessment of coagulation and fibrinolysis system functions, as well as vascular endothelial injury; however, their clinical application following intravenous thrombolysis for acute ischemic stroke (AIS) remains unclear. Therefore, our study aims to evaluate the dynamic levels of these novel thrombosis-related molecular markers within 24 hours after intravenous thrombolysis in patients with AIS and analyze their relationship with patients outcome.
Methods:
We conducted a retrospective cohort study based on the data of 77 patients with AIS who underwent alteplase intravenous thrombolysis between November 2022 and February 2024. Novel thrombotic markers were evaluated at four time points: prior to thrombolysis, 1 hour after thrombolysis, 6 hours after thrombolysis, and 24 hours after thrombolysis. Based on the modified Rankin scale (mRS) score at day 90 post-discharge, patients were categorized into the good outcome group (mRS ≤ 1) and the poor outcome group (mRS > 1). Stepwise multivariate logistic regression was employed to analyze the association between 90-day functional outcomes and the measured variables. The area under the receiver operating characteristic curve (AUC) was utilized to assess the predictive ability of novel thrombotic markers.
Results:
Our study demonstrated that, compared to the poor outcome group, the good outcome group exhibited significant lower serum TAT levels both prior to thrombolysis and at 6 hours post-thrombolysis (all p < 0.05), and serum TM and t-PAIC levels were also significantly elevated in the good outcome group at 1 hour, 6 hours, and 24 hours following thrombolysis (all p < 0.05). Stepwise logistic regression analysis indicated that increased serum TM and t-PAIC levels at 24 hours post-thrombolysis were protective factors for a good 90-day outcome. The AUC values of TM, t-PAIC, and TM combined with t-PAIC for predicting 90-day functional outcomes were 0.918 (sensitivity 80.0%; specificity 85.7%), 0.658 (sensitivity 91.4%; specificity: 45.2%), and 0.984 (sensitivity: 97.1%; specificity 97.6%), respectively.
Conclusion:
Novel thrombotic molecular markers might serve as indicators for the early monitoring of dysfunction in the coagulation-fibrinolysis system and endothelial injury following intravenous thrombolysis for AIS. TM and t-PAIC exhibit predictive value regarding the outcome of intravenous thrombolysis in AIS, providing insights for future research on the protective role of TM in AIS.
CpG-mediated TLR9 signalling enhances the efficacy of the OprF/PcrV DNA vaccine with cGAS-STING-activating properties
Authors: Tian Linxia , He Hongxi , Liu Hanbai , Zhang Yating , Yu Xian
Published: December 2024

Background
Pseudomonas aeruginosa (PA) infection poses a major global threat to health care. DNA vaccines, which induce humoral and cellular immunity, are promising for preventing and treating PA infection. However, the low immunogenicity of DNA vaccines has limited its clinical application. Therefore, this study seeks to explore whether the OprF/PcrV DNA vaccine can activate the cGAS-STING pathway and boost the immunogenicity of the OprF/PcrV DNA vaccine by combining a CpG adjuvant which presumably activates the TLR9 pathway.
Results
We found that the DNA-OprF/PcrV + CpG could activate the cGAS-STING and TLR9 pathways, activate innate immune responses, and stimulate BMDC maturation. In addition, in vivo data revealed that the vaccine could induce strong antigen-specific cellular and humoral immune responses and protect mice with pneumonia from PAO1 infection by reducing the bacterial burden in the lungs and reducing lung inflammation. Finally, the DNA-OprF/PcrV + CpG vaccine showed reliable biosafety.
Conclusion
This study conclusively demonstrated that the DNA-OprF/PcrV vaccine, when combined with CpG, effectively stimulated the innate immune response through the cGAS-STING and TLR9 pathways, subsequently enhancing the adaptive immune response. This synergistic combination not only triggers robust humoral immunity but also enhances cellular immune responses, indicating that the DNA-OprF/PcrV + CpG vaccine may serve as a promising option against PA infection both intracellularly and extracellularly.
Traumrest und wunderlich gefärbtes Tageserleben
Authors: Gehrlach Andreas
Published: December 2024

Die Tagesreste wurden intensiv psychoanalytisch erforscht, ihr strukturelles Gegenteil dagegen überhaupt nicht. Die Traumreste, die aus dem Schlaf übrig bleiben und die Tönung und Empfindung ganzer Tage prägen können, sind bisher wissenschaftlich so gut wie unerforscht. Sie sind ein unbewusstes Phänomen, das aber weit in’s rationale Tageserleben hineinreicht und es umfärbt, sabotiert und in Frage stellt. Hier wird eine erste Skizze zu einer Erforschung der Traumreste versucht.
In Therapien
Authors: Junker Iris
Published: December 2024

Die Autorin beschreibt unterschiedliche therapeutische Erfahrungen, persönlich, poetisch, witzig und melancholisch zugleich. Sie stellt der Einzel-Psychoanalyse einerseits die Verhaltenstherapie, andererseits den Erfahrungsmoment in einer psychoanalytischen Gruppentherapie gegenüber.
Ohne
Authors: Solla Gianluca
Published: December 2024

Der Artikel vertieft innerhalb der Formel "Ohne Gewähr" dem Adverb "ohne" in seinen philosophischen Impikationen.
Fremdsprache(n) Unbewusst
Authors: Dulley Iracema
Published: December 2024

Mehrsprachigkeit in der Analyse hält die Illusion des Verstehens auf Abstand und lässt die Materialität des Signifikanten stärker hervortraten. Das Unbewusste, so lässt sich Lacans Dictum abwandelnd sagen, ist wie eine Fremdsprache strukturiert.
Die kommende Psychoanalyse
Authors: Habib Stéphane
Published: December 2024

Die kommende Psychoanalyse wird zur minimalen Definition der Psychoanalyse, indem diese auf die innwohnende politische Dimension der Psychoanalyse wettet. Hören, Empfangen, überrascht werden, einbrechen lassen was kommt, das was die identitäre Sicherung der Souveränität des Subjekts zerlegt. Die Psychoanalyse als Drekkologie, wie sie schon von Freud charakterisiert wurde, wird zum Hebel einer Zukunft, die es für die Psychoanalyse zu denken gilt, aber nicht nur für sie, denn das singuläre Subjekt, um das es ihr geht, ist kollektiv.
Laienexperten
Authors: Schwaiger Bernhard
Published: December 2024

Ausgehend von der Erfahrung der Universität des Begehrens hinterfragt dieser Beitrag ob die Leerstelle des Begehrens mit einer politischen Lehre besetzt werden kann, die das der lalangue anhaftende Genießen nicht umgeht. Die Freudsche Gleichsetzung der psychoanalytischen Behandlung mit einem chirurgischen Eingriff bietet Gelegenheit, die Konstitution des Operationsfeldes der Psychoanalyse zu hinterfragen: Wenn sie aus dem Begehren des Analytikers heraus stattfindet heisst das, dass das sich dort entfaltende Feld sich aus der Abweichung vom akademischen Wissen konstituiert, indem die Analytikerinnen, sowohl Experten als auch Laien, die Differenz zwischen akademischem und analytischem Wissen schützen und wirken lassen. Das Feld der Laienexperten Analytikerinnen ist daher das einer Klinik des Realen.
Wahren – währen – wehren
Authors: Widmer Peter
Published: December 2024

Der Artikel geht der Etymologie des Wortes "gewähren" nach.
Grundregel und Grenzgang
Authors: Wedemeyer Arnd
Published: December 2024

Die Frage nach einem (Nicht-)Verhältnis von Psychoanalyse und Recht lädt ein zu einer Vertiefung, in der ihre Begegnung unausweichlich wird. Die Frage der Gewährlosigkeit ist ein seltsamer Nachklang der von 1869 bis 1939 in Deutschland geltenden Kurierfreiheit. Freuds Schrift zur Laienanalyse, aber auch manche von Lacans Betrachtungen zeichnen sich dagegen durch einen Rekurs auf Figuren juridischer Reflexion aus, die auch der heutigen Kontestation der psychoanalytischen Praktiken gesetzten Grenzen Stoff geben kann.
Statistical analysis of the soil activity in Sheki-Zagatala economic region
Authors: Hasanova Turkan , Abasova Nazifa
Published: December 2024

This paper synthesizes findings from recent studies on the biological dynamics within these ecosystems. The aim of the work is to establish the limits and causes of variability of biological activity of soils in mixed forests of the Greater Caucasus, to identify existing relationships and to display them in the form of mathematical models. The selected Sheki-Zagatala economic region territories that receive the largest number of tourists and have high potential for ecotourism in the Republic of Azerbaijan. The Gakh, Sheki, Oguz and Gabala regions located on the southern slopes of the Great Caucasus Mountains in the territory of the Azerbaijan Republic were selected as the study area. The ecological indicators of the research area were studied. Bioecological studies of modern soil cover are very relevant; young soil scientists can use the results obtained as literary material. The results of the study of the composition of mountain-forest brown soils of the Azerbaijan Republic provide grounds for recommending agrotechnical and soil-protective measures aimed at maintaining, preserving, and, if necessary, recreating the structure of the soil to improve the productivity and yield of agricultural crops. To increase the biological activity of soils, it is necessary to manage their redox potential and density by optimizing the species composition of stands and regulating their density. On forest nurseries, biological activity of soils is increased by liming, balanced application of organic and mineral fertilizers, use of siderates on the correct selection of which the efforts of researchers should be directed. The article shows changes in the amount of carbon dioxide, biomass and phytomass depending on the agrochemical properties of soils
Nutrient intake and digestibility of west african dwarf rams fed basal diet supplemented with graded energy levels of concentrate mix
Authors: Jinadu Kabiru Babatunde , Adekanbi Oyefunke Abidemi , Abdulsalam Sherifdeen , Akingbade Olayide Aderemi , Abdulkabir Anif Olalekan , Osinubi Aanuoluwapo Adeleke , Akinwande Amos Adedayo , Adeniji Ezekiel Adetayo
Published: December 2024

The study investigated the effect of graded energy levels of concentrate mix on nutrient intake and digestibility of West African Dwarf rams fed basal diet (Pennisetum purpurem). A total number of twenty-five (25) West African Dwarf rams were used in a completely randomized design. The concentrate formulated at 2,600 kcal/kg, 2,400 kcal/kg, 2,200 kcal/kg, 2,000 kcal/kg and 1,800 kcal/kg energy levels as treatments 1–5 respectively. At the end of the feeding trial, rams were allotted into metabolic cages for separate feeding, collection of feces and urine. The faecal samples collected were bulked and 10 % aliquot was taken for chemical analysis. Results showed that the dry matter intake was significantly (p<0.05) influenced by the dietary energy intake which ranged from 314.6 to 326.6 g/day. Rams fed with 2600 kcal/kg recorded the highest dry matter intake, while rams on 2200kcal/kg observed with lowest dry matter intake (314.6 g/day). The crude protein intake was not significantly (p>0.05) affected by different energy intake. There were significant differences in Ether Extract intake as (13.51‒13.80 g/day), Ash intake as (25.73‒36.11 g/day), and Nitrogen Free Extracts as (67.28‒72.04 g/day). The fiber fractions were significantly (p<0.05) affected by different energy intake. Significant differences (p<0.05) were obtained for dry matter digestibility (72.69‒81.21 %), crude protein digestibility (59.41‒67.59 %), Nitrogen Free Extract digestibility (55.64‒63.52 %). It was therefore concluded that basal diet (Pennisetum purpurem) for West African Dwarf rams could be supplemented with 2,600 kcal/kg energy level of concentrate mix for better feed utilization and improved productivity
GESTION DES RISQUES PROFESSIONNELS ET ENVIRONNEMENTAUX DU SITE DE CONSTRUCTION DU POLE AGROALIMENTAIRE DE LAGGLOMERATION DU GRAND-NOKOUE
Authors:   Institut National Medico-Sanitaire (INMeS) de lUniversite dAbomey Calavi., Theodore Soussia , Thekpo Theodore Adjakpa ,   Centre Interfacultaire de Formation et de Recherche en Environnement pour le Developpement Durable (CIFRED) de lUniversite dAbomey Calavi., Perrin Assannon ,   Centre Interfacultaire de Formation et de Recherche en Environnement pour le Developpement Durable (CIFRED) de lUniversite dAbomey Calavi., Jerome Charles Sossa ,   Institut Regional de Sante Publique (IRSP) de lUniversite dAbomey Calavi., Jacques Vigan ,   Institut National Medico-Sanitaire (INMeS) de lUniversite dAbomey Calavi., Lisette Odoulami ,   Institut National Medico-Sanitaire (INMeS) de lUniversite dAbomey Calavi., Lamine Said Baba-Moussa ,   Faculte des Sciences et Techniques (FAST) de lUniversite dAbomey Calavi.
Published: December 2024

Introduction: Infrastructure construction makes a significant contribution to economic output. Risk is intrinsic to this activity it has always been present and constitutes its essence. The aim of this research is to manage the health, safety and environmental risks faced by workers in lot 1 of the Grand-Nokoue agrifood cluster.

Methods : The research is observational, cross-sectional, descriptive and analytical. It surveyed workers at the construction site of the agri-food cluster in the Grand-Nokoue agglomeration of Abomey-calavi. A simple random sampling technique was used, and 40 workers were selected for the survey. Data analysis was carried out using rating grids for the severity and frequency of exposure of workers and their environment to the identified risks. Observations in the study were presented in proportions for qualitative variables and quantitative data using central tendency parameters such as mean with standard deviation, median as appropriate, mode and extremums.

Results: The results show that workers and their working environment are at risk from collisions, falls from heights, falls to ground level, hearing disorders, respiratory and eye disorders, dust and exhaust emissions, hydraulic oil leaks, and deafening noise emissions. The risk analysis reveals that 32% of the occupational risks identified have a high gross level of occurrence, and 46% of the significant effects generated by activities on environmental components are of major importance.

Conclusion : Mitigation measures are proposed to minimize the level of occupational and environmental risks identified on lot 1. These mitigation measures take the form of instructions, technical resources, training and/or awareness-raising.
EVALUATION DE LEFFICACITE DES FOURMIS OECOPHYLLES (OECOPHYLLA LONGINODA) DANS LA LUTTE CONTRE LES MOUCHES DES FRUITS DANS LES VERGERS MANGUIERS DU NORD DE LA COTE DIVOIRE
Authors:   Centre National de Recherche Agronomique (CNRA), Direction Regionale de Korhogo, Station de Recherche de Lataha, ProgrammeAnacarde, Mangue, Papaye (AMP). SiegeSocial: Km 17 Route de Dabou / 01 BP 1740, Abidjan 01, Cote dIvoire., Coulibaly A. , Fondio D. ,   Universite Jean Lorougnon Guede (UJLoG), Laboratoire dAmelioration de la Production Agricole, Daloa BP 150, Cote dIvoire., Yeo F.E ,   Universite de Man (UM), UFR Ingenierie, Agronomie, Foresterie et Environnement, BP 20 Man, Cote dIvoire., Minhibo M.Y ,   Centre National de Recherche Agronomique (CNRA), Direction Regionale de Korhogo, Station de Recherche de Lataha, ProgrammeAnacarde, Mangue, Papaye (AMP). SiegeSocial: Km 17 Route de Dabou / 01 BP 1740, Abidjan 01, Cote dIvoire., R NDepo O ,   Universite Jean Lorougnon Guede (UJLoG), Laboratoire dAmelioration de la Production Agricole, Daloa BP 150, Cote dIvoire., Hala N.F ,   Centre National de Recherche Agronomique, Station de la Me, Abidjan, BP 989, Cote dIvoire.
Published: December 2024

In Cote dIvoire, with national production of around 180,000 tonnes, mango is the 2nd most important export fruit after bananas. The country is also the 3rd largest exporter of mango to the European market, with 33,000 t, after Brazil (100,000 t) and Peru (80,000 t). However, mango production is threatened by attacks from insect pests, of which fruit flies are the most damaging. The aim of this work is to help reduce the fruit fly population by using weaver ants as a biological control agent in mango orchards. Accordingly, a one-hectare area was delimited into two treatments, i.e. 24 trees per treatment at 3 different sites. The 1st treatment consisted of trees colonized by weaver ants, and the second treatment of trees not colonized by ants. In each treatment, a sample of 100 mangoes was collected, weighed and incubated in the laboratory in muslin-covered basins containing sterile sand. Two weeks later, the mangoes were washed and the number of pupae per kilogram of fruit per treatment was determined. The results showed that the number of pupae was lower in plots colonized by ants (4.24 Â± 1.78 pupae/Kg of mango) than in plots not colonized by ants (51.30 Â± 22.91 pupae/Kg of mango). In conclusion, weaver ants contribute to the reduction of fruit fly populations in mango orchards.
Perfil das(os) estudantes com vínculo de matrícula na educação especial participantes do Saeb (2011-2017)
Authors: Schneider Gabriela , Bruel Ana Lorena de Oliveira , Prieto Rosângela Gavioli , Mendes Enicéia Gonçalves
Published: December 2024

O presente estudo tem como objetivo analisar o perfil das(os) estudantes do público da educação especial (PEE) participantes nas edições do Saeb de 2011, 2013, 2015 e 2017, matriculadas(os) no 5º e 9º anos do ensino fundamental (EF) de escolas públicas em comparação com os dados do Censo Escolar nas mesmas séries e anos avaliados. A análise observa a participação com foco em características individuais e das escolas. Os resultados sugerem a participação expressiva com aumento percentual ao longo da série histórica, predominância de estudantes do sexo masculino e grande heterogeneidade desse público.
An optimisation of the adsorption method for faujasite zeolite-X synthesised from coal fly ash utilising RSM coupled with central composite design approach
Authors: Tirva Divya Omprakash , Sur Dharmesh
Published: December 2024

The main objective of this study was to evaluate the effectiveness of faujasite zeolite-X, which was produced from coal fly ash, in the removal of methylene blue dye. The zeolite was synthesised using hydrothermal treatment, and its properties were analysed using X-ray diffraction, scanning electron microscopy with energy-dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy. Response surface methodology was utilised, employing a central composite design (CCD), to optimise the adsorption parameters. The study examined the impact of four primary variables – initial dye concentration, zeolite-X dose, reaction time, and temperature – on the elimination of dye. An analysis of variance was performed to evaluate the accuracy of the parameters and regression coefficients. The experimental data exhibited a high degree of agreement with the model predictions, as shown by an R2 value of 0.997. The maximum effectiveness of dye removal was achieved at 99.23% under the following ideal conditions: an initial dye concentration of 125 mg/L, a zeolite dose of 2.5 g/L, a temperature of 55 °C, and an adsorption period of 40 min. The results validate the strong effectiveness of faujasite zeolite-X in removing dye from wastewater, as demonstrated by the Langmuir isotherm study (R2= 0.99).
Mobilização e participação em torno da Lei Aldir Blanc
Authors: Barbalho Alexandre , Costa Silva do Nascimento Bruna
Published: December 2024

Este artigo tem como foco analisar como se deu no Ceará a mobilização e a participação em torno da elaboração e aprovação da Lei Aldir Blanc (LAB) e da posterior construção do plano de aplicação dos recursos. A questão é perceber o desafio das instituições do setor cultural de estreitar o diálogo com a sociedade civil, na tentativa de dar conta dos múltiplos contextos e de executar a lei em tempo hábil — isso em um estado que se tornou referência nacional na condução de políticas culturais no contexto pandêmico. Para tanto, recorremos a um conjunto de fontes (documentos, entrevistas, hemerográficas, bibliográficas) para remontar o processo em tela, contextualizando o cenário político brasileiro e o movimento participativo que envolveu o desenvolvimento da LAB e analisando como se deu esta mobilização no Ceará.
Gestão pública, democracia e participação: um estudo de caso sobre a efetividade participativa dos conselhos de saúde dos municípios da 7ª coordenadoria regional de saúde do estado do ceará
Authors:   , Silva Carlúcio Germano da
Published: December 2024

A relação gestão pública-democracia-participação é tema cercado de controvérsia e, hoje, considerando o quadro político-administrativo brasileiro, mantém-se alvo de discussão importante. Nesse contexto, pelo presente trabalho, busca-se avaliar a efetividade participativa dos Conselhos Municipais de Saúde (CMS’s) dos municípios que compõem a 7ª Coordenadoria Regional de Saúde (CRES) do Ceará. Faz-se isso em consonância ao marco jurídico e político inaugurado pela Constituição Federal de 1988, sob a luz da teoria da democracia participativa inclusiva. Para isso, parte-se de uma abordagem que arregimenta categorias chave das áreas jurídica e, inelutavelmente, da política, colocando-se em pauta questões estruturais e normativas em paralelo com a proposta metodológica da participação em 4 D’s (Densidade, Diversidade, Durabilidade e Capacidade Deliberativa). Busca-se abordar outras alternativas para além das que centralizam nas categorias como cooptação e elites o principal elemento a ser considerado para propor uma imersão quali-quanti sobre o processo decisório no âmbito desses colegiados. No campo dos resultados, observa-se uma série de falhas estruturais e descumprimentos de normas e princípios democráticos em prejuízo de uma participação efetiva nesses Conselhos. Em face disso, foi confirmada a hipótese de pesquisa, segundo a qual os CMS’s analisados funcionam essencialmente como um foro chancelador de atos e políticas aprioristicamente costuradas pelo Executivo municipal, como consequência da falta de recursos, de uma vocalização fraca, do protagonismo de terceiros que não sejam membros destes foros participativos e pela sedimentação de um desequilíbrio na partilha de poder objetivada pelo legislador constituinte ao instituir a gestão participativa da saúde pública brasileira.
Contratações públicas como indutoras ao desenvolvimento econômico regional: um estudo com empresas do município de mossoró/rn
Authors:   , Diniz Isac Dantas
Published: December 2024

O objetivo principal deste trabalho foi analisar como se dá a participação das empresas
localizadas do município de Mossoró/RN, nas licitações públicas realizadas por órgãos do
governo federal localizados em sua região, de forma a identificar os fatores que dificultam ou
desestimulam a participação das empresas locais no mercado das contrações públicas. O estudo
tem uma abordagem qualitativa, utilizando-se da triangulação na coleta de dados por meio de
observação, análise documental e entrevistas. Em conseguinte, valeu-se da estatística descritiva
e do método de análise de conteúdo para analisar os dados coletados. A etapa da coleta de
dados secundários foi realizada por meio de pesquisa bibliográfica, além de pesquisa
documental, com dados extraídos do Painel de Compras do Governo Federal. No caso dos dados
primários, a coleta ocorreu mediante entrevistas junto a empresas que atuam na venda de
insumos e equipamentos agropecuários, sediados no município de Mossoró/RN. Verificou-se
que apesar dos avanços trazidos pelas plataformas eletrônicas de compras, quanto à
transparência e publicidade nas contratações públicas do governo federal, bem como o
incremento de legislações específicas que tratam de incentivos a participação de micro e
pequenas empresas locais nessas contratações, essas ações não fomentaram de forma
satisfatória e efetiva a participação do empresariado local nas contratações públicas do governo
federal.
CIDADES POR E PARA MULHERES: UMA PERSPECTIVA DE DESIGN FEMINISTA
Authors: Giulia Locatelli  , Karine Freire
Published: December 2024

Este estudo constitui o recorte de uma pesquisa de mestrado concluída em 2023. Ele apresenta uma reflexão teórico-crí tica, por meio de uma revisão bibliográfica, a respeito da perspectiva predominantemente patriarcal presente no planejamento e nas dinâmicas sociais das cidades. Com base nessa constatação, tem-se como objetivo sustentar a hipótese de que o design pode vir a atuar como o articulador de uma cidade desenvolvida por e para mulheres, desde que adotada uma mudança de paradigma nessas áreas por meio do feminismo. Assim, propõem-se caminhos para promover uma abordagem mais inclusiva e sensível ao gênero no design e no planejamento urbano.
PERSPECTIVAS E DESAFIOS PARA O REÚSO E REAPROVEITAMENTO DE RESÍDUOS DE CONSTRUÇÃO E DEMOLIÇÃO: O CONTEXTO BRASILEIRO
Authors: Roberta Sales Domingues  , Viviane dos Guimarães Alvim Nunes
Published: December 2024

O setor da construção civil, responsável por até 40% das emissões globais de CO2, enfrenta grandes desafi os ambientais por conta do aumento dos resíduos de construção e demolição (RCDs). No Brasil, a prática do reúso e reaproveitamento desses resíduos pode se tornar uma alternativa sustentável para minimizar tais impactos, embora existam barreiras signifi cativas na área. Este artigo investiga as potencialidades e os desafi os no reúso e reaproveitamento de RCDs no contexto brasileiro. A metodologia utilizada foi uma revisão sistemática da literatura por meio da análise de dez estudos que tratam do tema. Os resultados evidenciam tanto oportunidades econômicas e ambientais (como a redução de custos nas obras) quanto barreiras (a falta de políticas públicas efi cazes e de dados precisos sobre a geração de resíduos, por exemplo). Conclui-se que, para um avanço efetivo no ramo, são necessários mudanças legislativas, incentivos econômicos e maior conscientização ambiental.
Comprehensive Insights into Cephalosporins: Spectrum, Generations, and Clinical Applications
Authors: Nayeem Afreen , S Ankul Singh , Vellapandian Chitra , Singh Srishti , Elossaily Gehan M , Prajapati Bhupendra G.
Published: December 2024

Cephalosporins, a widely utilized class of antibiotics in clinical settings for bacterial infections,
are the focus of this critical analysis. This examination aims to provide a comprehensive
description, encompassing their range, generational distinctions, and therapeutic applications. Renowned
for their versatility against both Gram-positive and Gram-negative bacteria, cephalosporins
have evolved over generations, enhancing efficacy and addressing resistance patterns. Each generation
possesses unique characteristics crucial for clinical utility. Primarily targeting Gram-positive
cocci, first-generation cephalosporins exhibit a broadened spectrum in subsequent generations, encompassing
Gram-negative species. Advancements in penetration into tissues and resistance against
beta-lactamases contribute to increased effectiveness as generations progress. Clinically, cephalosporins
find application across diverse medical disciplines, from intricate hospital environments to
community-acquired illnesses. A comprehensive understanding of each generation's distinct features
empowers clinicians to tailor treatment regimens, optimizing therapeutic outcomes and mitigating
resistance risks. This meticulous examination consolidates the latest available information on cephalosporins,
serving as an invaluable resource for medical professionals involved in antibiotic prescription
and infection management. A profound understanding of cephalosporin characteristics and generations
proves indispensable in navigating the dynamic landscape of bacterial resistance, ultimately
enhancing patient care.
Emblica officinalis in Preventing Metabolic Syndrome: A First Review Addressing the Benefits and the Mechanism of Action
Authors: Prabhakar Pankaj , Marakala Vijaya , Sacheendran Dhanya , D’souza Rhea Katherine , D’souza Rashmi Theresa , Jayandran Mamatha , Pavankumar Giriyapura S. , Palatty Princy L. , Baliga Manjeshwar Shrinath
Published: December 2024

Globally, metabolic syndrome has increased a lot and affecting people of the
productive age group. The fruits of Emblica officinalis or Phyllanthus emblica
colloquially known as Amla or Indian gooseberry and their active components have
been investigated and observed to be beneficial. Amla possesses beneficial effects
against metabolic syndrome in both preclinical, and clinical studies. Amla decreases
the components of metabolic syndrome like blood pressure, glucose levels, obesity, and
cholesterol levels. Moreover, hepatic triacylglycerol, total cholesterol, and oxidative
stress were also attenuated by amla treatment. Amla was found to augment adiponectin
levels in adipocytes and hepatic PPAR-α levels as well as decline hepatic regulatory
element-binding protein (SREBP-1c) expression caused by high-fat diet in rats. Amla
possesses gallic acid, ellagic acid, and polyphenol, which are also beneficial. Amla
possesses anti-inflammatory properties by downregulating the expression of pERK,
TNF-α, pP38, IL6, COX2, and NOX-4 in metabolic syndrome. Furthermore, amla acts
through liver X receptor (LXR), farnesoid X receptor (FXR), PPARγ, cEBPα, FABP4 cyclo-oxygenase-2, SREBP-1c, and NF-κB to improve the components of metabolic
syndrome. This chapter analyses the encouraging properties of Amla fruit, and its
phytoconstituents in metabolic syndrome.
Metabolomics Quantitative Trait Loci Mapping of Medicinal Plants and Crops
Authors: Verma Pratiksha , Maurya Vikash , Yadav Vikas Kumar , Malhotra Manisha , Shweta  , Kumar Akhilesh
Published: December 2024

Genetic association studies and quantitative trait loci (QTL) analysis serve
as indispensable tools for identifying genes and genomic regions associated with
various traits. The rapid development of genomics and its application in plant breeding
has profoundly impacted the field, fostering discoveries and revolutionizing breeding
strategies. For a better understanding of plant physiology, complete information on
biochemical pathways is imperative across different organizational levels,
encompassing simple to intricate networks that regulate trait expression. Over the past
decades, the emergence of metabolomics as a vital branch of “omics” has played a
pivotal role in determining and quantifying metabolites governing cellular processes.
The combination of metabolomics and post-genomic approaches has recently allowed
proficient examination of genetic and phenotypic associations in cultivated crops. A
novel and powerful methodology, Metabolomic Quantitative Trait Locus (mQTL)
mapping, has emerged as an approach to unravel the genetic components and loci
contributing to the variability in metabolic profiles. This chapter provides an in-depth
exploration of mQTL mapping in both medicinal and crop plants, elucidating its
significance in unraveling the intricate interplay between genetics and metabolic
pathways.
Pathways of Important Metabolites and Enzymes Involved
Authors: Ganotra Jahanvi , Supolia Damini , Sharma Akanksha , Raina Meenakshi , Negi Neelam Prabha , Gautam Vibhav , Kumar Deepak
Published: December 2024

Plants produce diverse chemical compounds that play a crucial role not only
in plant growth and development but also hold great economic and ecological
importance for mankind. Plants synthesize these compounds to cope with various
abiotic and biotic stresses and also in response to the incessantly changing surrounding
environment. Broadly, these compounds are categorized as primary and secondary
metabolites. While the former play direct roles in plant growth, development,
functioning, defense, and stress tolerance, the latter do not hold any direct importance
in the growth and development of plants. Primary metabolites include carbohydrates,
organic acids, flavonoids, vitamins, amino acids, glucosinolates, hormones, and
phenolics. These are also widely used by humans as dietary compounds. Secondary
metabolites, on the other hand, can be broadly sub-divided into four major groups, i.e.,
terpenoids, phenols, alkaloids, and sulphur-containing compounds. These compounds
perform various other physiological roles like protecting plants against microbes and
herbivory, insect repellents, allelopathic agents, attractants for pollinators and seed
dispersal agents, regulating symbiosis, providing structural support to plants, and
alleviating biotic stresses. Additionally, they are also extensively used in cosmetics and
pharmaceutical industries, as well as the production of fragrances, drugs, dietary
supplements, dyes, and flavours. Although, a myriad of these metabolites are
synthesized by plants, and are basically derived by modifying the basic chemical
structure of compounds already present in plants. This chapter, therefore, elucidates the biosynthetic pathways of some of the major plant metabolites, giving special attention
to the key enzymes involved.
Polymers in Diagnostics
Authors: Pawar Ashish Y. , Albhar Shubhangi N. , Kothawade Sachin Namdeo , Sonawane Deepak D.
Published: December 2024

Historically, laboratory verification has been the mainstay of medical
diagnostics. This has resulted in arduous processes, expensive equipment, and a
shortage of medically educated workers, not to mention delayed findings. However, the
growing need for point-of-care medical testing devices coupled with the ongoing
medical and digital technology integration has made it easier to create devices that have
high selectivity, specificity, and quick reaction times. Every pandemic has brought
attention to the development of these devices on a global scale, underscoring the
pressing need to improve accurate, timely, and dependable medical diagnosis and
treatment. The need for innovative methods of identifying biological entities with quick
and precise diagnostic capacities is now growing steadily. Polymeric materials have
been used as a key component in the development of several analytical procedures.
Due to their easily adjustable characteristics, including their viscoelasticity, chemical
and mechanical resistance, and adaptability, polymers have a wide range of uses. The
fundamental benefit of employing polymers is their adaptability when mixed with other
materials to produce products with a variety of physicochemical properties. Therefore,
the physicochemical qualities of the polymer, which include its physical and chemical
characteristics, may be changed to suit the needs of a particular application, which are
Polymer-Based Sensors, Lab-on-a-Chip Technologies, and Polymer-Mediated Imaging
Agents. Special focus is on polymers that form multifunctional, stable systems with
nanostructured architecture. This chapter provides an overview of the sorts of
polymeric materials and how they function in the operation of important diagnostic
equipment.
A Treatise on Ecological Science
Authors: Rai Vikas
Published: December 2024

A Treatise on Ecological Science provides a fresh perspective on modern ecological thought by exploring topics often overlooked in traditional ecological texts. The book opens with a discussion of Network Ecology, unraveling the interconnectedness of ecosystems, and transitions to the intricate relationship between biodiversity and climate change. It further addresses Human Ecology, highlighting its central role in shaping ecological discourse, and explores the principles of Industrial Ecology, emphasizing sustainable practices in industrial systems. The final chapter critically examines the Sustainable Development Goals, offering a balanced view of their benefits and limitations.

Designed to bridge gaps between ecology, industry, and global sustainability, this book serves as an insightful resource for students, researchers, and policymakers interested in contemporary ecological science and its practical applications.

Key Features:
- Examines underexplored topics in ecological science.
- Connects biodiversity, climate change, and human ecology.
- Highlights the role of industrial ecology in sustainability.
- Provides a critical analysis of Sustainable Development Goals.
Analisis Perkembangan dan Dinamika Pendidikan Karakter dan Budaya Bangsa Indonesia: Sebuah Upaya Pencapaian Tujuan Pendidikan
Authors: Suriaman Suriaman , Sundawa Dadang , Nurgiansah T Heru , Insani Nisrina Nurul
Published: December 2024

The history of character education and national culture in Indonesia dates back to before the independence of Indonesia. Character education started from the traditional education system by emphasizing on life values, ethics, and morality both in formal education and non-formal education. In addition, the influence of religion also plays a major role in shaping the character and culture of the nation. After independence, character education and national culture received serious attention through integration in school learning. The achievement and development of character education and national culture experience dynamics due to several factors such as changes in social values, the influence of mass media. Limited resources, lack of awareness of the urgency of character education, and also religious and cultural differences as a multicultural nation. This article uses a qualitative approach with a literature review method from scientific sources. The results of the review analysis resulted in the development of character education theory and national culture has become a major concern in an effort to build a young generation that has moral values, ethics, and love for the nation's culture. Some efforts that can be made to instill and develop character education in formal education such as improving teacher training, developing a curriculum that is integrated with national character values, encouraging parental participation, collaborating with religious communities, social, and art groups, providing adequate educational resources.
Behavior Changes in Older Adults During Adverse External Events: A Longitudinal Observational Study (Preprint)
Authors: Fritz Roschelle , Cook Diane
Published: December 2024

BACKGROUND

Older adults manage multiple impacts on health, including chronic conditions and adverse external events like pandemics and wildfires. Understanding behavior changes related to these events is important for assessing risk and designing interventions. Information derived from smart home sensors can provide objective data about behavior changes to support a learning healthcare system.

OBJECTIVE

Our objective is to examine digital markers collected before and during two events (COVID-19 pandemic, wildfires) to determine whether clinically relevant behavior changes can be observed and targeted upstream interventions suggested.

METHODS

Secondary analysis of historic ambient sensor data collected on n=39 adults managing one or more chronic conditions was performed. Interrupted Time Series analysis was used to extract behavior markers related to external events. Comparisons were made to examine differences between exposures using machine learning classifiers.

RESULTS

Significant pandemic-related behavior changes ranked by impact included a (3.8 hours/day) decrease in time spent out of home, increase in restless sleep (946.74%), and decrease in indoor activity (38.89%). Although participants exhibited less restless sleep during exposure to wildfire smoke (120%), they also decreased their indoor activity (114.29%). Sleep duration trended downward during the pandemic shutdown. Time out of home and sleep duration gradually decreased while exposed to wildfire smoke. Behavior trends differed across exposures.

CONCLUSIONS

Behavior changes were detected for the two adverse external events (pandemic, wildfire smoke) initially and over time. However, the direction and magnitude of change differed between participants and events. Sensor-based findings could support the learning healthcare system’s ability to promote health equity ideals by providing environmental contexts affecting social determinants of health. The smart home’s novel, evidence-based information could inform future management of chronic conditions, allowing nurses to understand patients’ health-related behaviors between the care points so timely interventions are possible.

CLINICALTRIAL

N/A
Expectation of success in Virtual Medical Rehabilitation (Preprint)
Authors: Waldmann Guido , Raab Dominik
Published: December 2024

BACKGROUND

More than a few concepts have been presented in rehabilitation clinics that implement aspects of modern information technology in the arrangement of augmented reality or virtual rehabilitation aiming to enhance cognitive or motor learning and rehabilitation motivation. Despite their scientific success, it is currently unknown whether rehabilitants will accept rehabilitation concepts that integrate modern information technologies.

OBJECTIVE

...

METHODS

111 rehabilitation patients were surveyed about the subjective performance expectations of virtual reality in 15 therapeutic fields with a questionnaire. The distribution of the responses was evaluated using box plots. The relationship between the subjective performance expectations for the 15 therapeutic fields was analyzed with Spearman’s rho, while the Mann-Whitney U test was used for comparisons of the subjective performance expectations between age-groups and between genders.

RESULTS

For all 15 therapeutic fields the median of the subjective performance expectations was between 2 and 3, while therapeutic fields in the categories “activity / movement”, “competence of daily live / communication” and “education” tended to be rated higher than therapeutic fields in the categories “relaxation / passive measures” and “advisory / conversation”. Significant rank correlation could be observed for 103 out of 105 pairwise comparisons of the therapeutic fields, with distinct patterns of effects sizes within the chosen categories. There was no statistically significant difference in the evaluation between rehabilitants of employable age and those of age 68 years or older. Male rehabil-itation patients reported greater subjective expectations for virtual rehabilitation than female patients, but there was only a significant difference with small effect sizes for 3 of the 15 therapeutic fields.

CONCLUSIONS

The general trend is that patients can imagine taking part in virtual reality in rehabilitation activities involving active movement (physiotherapy, sports and exercise therapy, occupational therapy) and also in health education. The results of the survey show that there is also a high level of support for the therapeutic field advisory/conversation.
Current circumstances have led to a substantial use of virtual offerings in practice. The limited data available may have encouraged the professional development of virtual reality systems and their widespread use in medical rehabilitation follow-up in the home setting.