bluuebunny/crossref_metadata_2025 huggingface dataset:
Déjà vu: A reappraisal of the taphonomy of quarry VM4 of the Early Pleistocene site of Venta Micena (Baza Basin, SE Spain)
Authors: Palmqvist Paul , Espigares M. Patrocinio , Pérez-Claros Juan A. , Figueirido Borja , Guerra-Merchán Antonio , Ros-Montoya Sergio , Rodríguez-Gómez Guillermo , García-Aguilar José Manuel , Granados Alejandro , Martínez-Navarro Bienvenido
Published: November 2021

Venta Micena, an Early Pleistocene site of the Baza Basin (SE Spain), preserves a rich and diverse assemblage of large mammals. VM3, the main excavation quarry of the site, has been interpreted as a den of the giant hyaena Pachycrocuta brevirostris in the plain that surrounded the Baza palaeolake. Taphonomic analysis of VM3 has shown that the hyaenas scavenged the prey previously hunted by the hypercarnivores, transported their remains to the communal den, and consumed the skeletal parts according to their marrow contents and mineral density. In a recent paper, a small sample of remains unearthed from VM4, an excavation quarry ~350 m distant from VM3, are analysed. The authors indicate several differences in the taphonomic features of this assemblage with VM3, and even suggest that a different carnivore could have been the agent involved in the bone accumulation process. Here we make a comparative analysis of both quarries and analyse more skeletal remains from VM4. Our results indicate that the assemblages are broadly similar in composition, except for slight differences in the frequency of megaherbivores, carnivores and equids according to NISP values (but not to MNI counts), the degree of bone weathering, and the intensity of bone processing by the hyaenas. Given that VM4 and VM3 were not coeval denning areas of P. brevirostris, these differences suggest that during the years when the skeletal remains were accumulated by the hyaenas at VM3, the rise of the water table of the Baza palaeolake that capped with limestone the bones was delayed compared to VM4, which resulted in their more in-depth consumption by the hyaenas.
Lateral Pillar is the Key in Supporting Pre-collapse Osteonecrosis of the Femoral Head: A Finite Element Model Analysis of Propensity-Score Matched Cohorts
Authors: Bahk Ji Hoon , Jo Woo-Lam , Kim Seung-Chan , Kwon Soon-Yong , Lim Youngwook
Published: November 2021

Background
This study was designed as a cohort study using propensity-score matching to age and gender for finite element model (FEM) analysis from pre-collapse CT images of collapsed and non-collapse hips. Through FEM analysis, a global graphical output around the hip joint can provide simple impression of stress distribution: concentration or dispersion.
Methods
32 hips with ARCO stage 2 or 3 ONFH who were on follow up for over one-year period were retrospectively reviewed. 16 hips with no interval progression of collapse were set as the study group, then 16 hips with progression of collapse which required arthroplasty were set as the control group using propensity-score matching. FEM was generated through Mechanical Finder for each patient, then 4500 Newtons of load was applied to 1,000mm2 area at the top of iliac crest to analyze equivalents for yield stress.
Results
Age, sex, and BMI had no significant differences, while location (p=0.015) was lateral, and size (p=0.015) was significantly greater in the collapsed group. Non-collapsed hips mostly exhibited stress dispersion allocated to medial and lateral pillars, while collapsed hips exhibited stress concentration focused on the lateral pillar and the primary compression trabecula. (p=0.001)
Conclusion
FEM analysis suggests stress concentration to the lateral pillar and the primary compression trabeculae can predict future collapse in ONFH with high probability. Results provide a simple and intuitive, yet valuable information to aid surgeons. Therefore, especially for young patients, holding out the lateral pillar through joint preserving procedures might be the key in preventing further collapse.
Impact of Intravesical instillation of a Novel Biological Response Modifier (P-MAPA) on Progress of Non-Muscle Invasive Bladder Cancer Treatment in a rat model
Authors: Fávaro Wagner J. , Socca Eduardo A.R. , Böckelmann Petra K. , Reis Ianny B. , Garcia Patrick V. , Duran Nelson
Published: November 2021

This work describes the effects of immunotherapy with Protein Aggregate Magnesium-Ammonium Phospholinoleate-Palmitoleate Anhydride (P-MAPA) in the treatment of non-muscle invasive bladder cancer (NMIBC) in an animal model. NMIBC was induced by treating female Fischer 344 rats with N-methyl-N-nitrosourea (MNU). After treatment with MNU, the rats were distributed into four experimental groups: Control (without MNU) group, MNU (cancer) group, MNU-BCG (Bacillus Calmette-Guerin) group and MNU-P-MAPA group. P-MAPA intravesical treatment was more effective in histopathological recovery from cancer state in relation to BCG treatment. Western blot assays showed an increase in the protein levels of c-Myc, COUP-TFII and wild-type p53 in P-MAPA-treated rats in relation to BCG-treated rats. In addition, rats treated with P-MAPA intravesical immunotherapy showed the highest BAX protein levels and the lowest proliferation/apoptotic ratio in relation to BCG-treated rats, pointing out a preponderance of apoptosis. P-MAPA intravesical treatment increased the wild-type p53 levels and enhanced c-Myc/COUP-TFII-induced apoptosis mediated by p53. These alterations were fundamental for histopathological recovery from cancer and for suppress abnormal cell proliferation. This action of P-MAPA on apoptotic pathways may represent a new strategy for treating NMIBC.
From Asymmetrical to the Nonreciprocal Isolator Using Time-varying Metasurfaces
Authors: Khorrami Yaser , Fathi DAVOOD , Khavasi Amin , Rumpf Raymond C.
Published: November 2021

We present an emulation design method for converting asymmetric isolators to nonreciprocal ones using time-varying metasurfaces. To illustrate the model, we design a structure using a combination of the photonic crystal (PhC) and time-varying metasurface. Moreover, we propose a general approach for numerical analysis of the time-modulated proposed structure using the extension of the transfer matrix method (TMM) which consists of working through the device one layer at a time and calculating an overall transfer matrix including the time-variation of the permittivity and permeability in each layer. Also, we use an optimization algorithm that is less used in the field of electromagnetism but is suitable for fast and accurate parameter optimization. The results show that the proposed method, using pure time-varying metasurfaces which cannot prepare full nonreciprocity alone, is a promising procedure for breaking the Lorentz reciprocity in the general isolator system as well as maintaining the previously asymmetric designed structure.
Kinetics of the SARS-CoV-2 antibody response in immunocompetent convalescent patients: nationwide multicenter 15-month follow-up cohort study
Authors: Movsisyan Mariam , Chopikyan Armine , Kasparova Irina , Hakobjanyan Gohar , Carrat Fabrice , Mekinian Arsene , Sukiasyan Meline , Rushanyan Marieta , Chalabyan Mariam , Sharif Sanobar , Kantawala Burhan , Hovhannisyan Alvard , Hakobyan Armine , Minasyan Armen , Muradyan Armen , Petrosyan Gaiane , Yenkoyan Konstantin
Published: November 2021

The comprehension of a long-term humoral immune response against the SARS-CoV-2 virus can shed light on the treatment and vaccination of the disease, improve the control of the pandemic infection. We assessed the antibodies against SARS-CoV-2 nucleocapsid (N) protein in 1441 COVID-19 convalescent patients within 15 months longitudinal nationwide multicenter study from middle-developed country. 92.7 % of convalescent patients’ serum contained antibodies against N protein and only 1.3% of patients had a delayed antibody response. In the majority of convalescent patients’ the durability of antibodies lasted more than one year. The kinetics of neutralizing antibodies took a bell-shaped character – increased first 25-30 weeks, then started to decrease, but were still detectable for more than 15 months. Summing up, we found that anti-SARS-CoV-2 humoral response levels, in particular the level of peak antibodies, correlate with age, older patients developing more robust humoral response independently from sex, disease severity and BMI.
The Influence of Different Anti-PD-1 Monoclonal Antibody Concentrations On T Cell Activation in in - Vitro Culture – A Preliminary Study
Authors: Wieleba Irena , Wojas-Krawczyk Kamila , Chmielewska Izabela , Wójcik-Superczyńska Magdalena , Krawczyk Paweł , Milanowski Janusz
Published: November 2021

Lung adenocarcinoma predominates among diagnosed nonsmall cell lung cancer subtypes in nonsmokers. The introduction of immune checkpoint inhibitors into clinical practice offered patients prolonged progression-free survival and overall survival times. However, the results demonstrate that the benefits do not apply to all patients. Nivolumab is a monoclonal antibody against the PD-1 protein expressed mainly on T lymphocytes and is widely used in cancer therapy in different settings. Tumor cells often express the PD-L1 molecule and can effectively block the action of PD-1-positive lymphocytes. A body of knowledge regarding the high expression of PD-L1 on tumor cells highlights that it does not always correlate with the effectiveness of anti-PD-1 therapy. The side effects of the therapy also constitute a significant issue. These side effects can occur at any time during anti-PD-1 treatment and lead to discontinuation and even the death of the patient. In these situations, it is possible to delay the dosage. Nevertheless, unfortunately, it is not possible to reduce the dose of anti-PD-1 antibody, which would undoubtedly minimize side effects, leaving the patient's immune system active. In our preliminary study, we analyzed the effect of different concentrations of nivolumab on the functioning of T lymphocytes. Activation and proliferation markers were investigated on T cells after being cultured with antigen-stimulated autologous dendritic cells. This process may indicate an appropriate concentration of nivolumab, which shows clinical activity with minimal side effects.
Possible Sources of Trigger Mechanism of Electron-phonon Interactions in Doped CuTl-1223 Superconductors
Authors: Kanwal Anila , Khan Nawazish Ali
Published: November 2021

This article underlines the important role of copper Cu(3d9) spins at the CuO2 planer sites to comprehend the physics of High temperature Superconductivity . In such studies we have reported the characterization results of samples (Cu0.5Tl0.5)Ba2Ca2Cu3O10-δ , (Cu0.5Tl0.5)(BaCa)(CaMg)Cu1Zn2O10-δ , (Cu0.5Tl0.5)(BaCa)(CaMg) Zn3O10-δ and (AyTl1-y)(BaCa)(CaMg) Zn3O10-δ (A=Ag, K, Ni, Mn; y=0,0.5). Samples were prepared at normal pressure by using two-steps solid state reaction method. The characterization of samples is done via x-ray diffraction (XRD), resistivity (RT) and Fourier Transform Infrared (FTIR) absorption measurements. Intrinsic superconducting parameters and activation energy of all sample is estimated applying two theoretical models, Fluctuation Induced conductivity (FIC) analysis and Mott 3D-VRH. The XRD and FTIR absorption measurements have confirmed the intrinsic doping of K, Ag, Ni, Mn and Zn. Interestingly, samples (Cu0.5Tl0.5)(BaCa)(CaMg) Zn3O10-δ without CuO2 planes have exhibited superconducting behavior above 77K. To verify the role of Cu(3d9) atoms in superconductivity we have synthesized (AyTl1-y)(BaCa)(CaMg) Zn3O10-δ (A=Ag, K, Mn, Ni; y=0,0.5) samples. In aforementioned samples, doping of Ni, Mn, K, Ag ions in Cu1-xTlxBa2O4-δ charge reservoir layer instead of Cu-atoms destroys the superconductivity completely and leads to semiconducting behavior. Key objective to preparing these samples is to investigate the role of two major parameters local moments (spin) of copper atoms and net carrier’s concentration in superconductivity.
TRPV4-mediated Ca2+ influx is essential to glomerular endothelial inflammation in sepsis associated acute kidney injury
Authors: Wang Xia , Wang Yinhua , Zhou Guo , Li Yi , Huo Huanhuan , Liang Feng , Xue Jieyuan , Shi Xin , Yin Anwen , Xiao Qingqing , Shen Linhong , He Ben
Published: November 2021

Background

Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of critical patients and is associated with high morbidity and mortality. The glomerular endothelial cell injury is the main characteristics during S-AKI. Ca2+ influx is a key step in the establishment of endothelial injury. Transient receptor vanilloid subtype 4 (TRPV4) ion channels are permeable to Ca2+ and are widely expressed in endothelial cells. However, the role of TRPV4 on glomerular endothelial inflammation in S-AKI has remained elusive.
Methods

Mouse glomerular endothelial cells (MRGEC) were used to test the molecular mechanism of TRPV4 on LPS-induced glomerular endothelial inflammation. The cecal-ligation-and-puncture (CLP) model was established by ligation of cecum with 4-0 suture and punctured with a 21-gauge needle. Then 0.2mL faeces was extruded from the puncture site to trigger peritoneal inflammation.
Results

In the present study, we found that blocking TRPV4 diminishes LPS-induced cytosolic Ca2+-elevations, which are essential for glomerular endothelial inflammation and barrier function. Furthermore, TRPV4 regulated LPS-induced phosphorylation and translocation of NF-κB and IRF-3 in mouse glomerular endothelial cells (MRGEC). Clamping intracellular Ca2+ mimics the LPS-induce response seen in the absence of TRPV4. In vivo, pharmacological blockade or knock down of TRPV4 reduced the inflammatory response of glomerular endothelial cells, inhibited translocation of NF-κB and IRF-3, increased survival rate and improved renal function in CLP-induced sepsis but without altering renal cortical blood perfusion.
Conclusions

Taken together, these results suggested that inhibition of TRPV4 ameliorates glomerular endothelial inflammation, kidney dysfunction, and increased mortality via mediating Ca2+ overload and NF-κB/IRF-3 activation. These discoveries may provide novel pharmacological strategies for the treatment of glomerular endothelial dysfunction and kidney injury during endotoxemia, sepsis, and other inflammatory diseases.
K-clique percolation in free association networks. The mechanism behind the 7 ± 2 law?
Authors: Valba Olga , Gorsky Alexander
Published: November 2021

It is important to reveal the mechanisms of propagation in different cognitive networks. In this study we discuss the k-clique percolation phenomenon on the free association networks including "English Small World of Words project" (SWOW-EN). We compare different semantic networks and networks of free associations for different languages. Surprisingly it turned out that k-clique percolation for all k < k c = (6 − 7) is possible on free association networks of different languages. Our analysis suggests the new universality patterns for a community organization of free association networks. We conjecture that our result can provide the qualitative explanation of the Miller’s 7 ± 2 rule for the capacity limit of working memory. The new model of network evolution extending the preferential attachment is suggested which provides the observed value of k c .
Can thickness of subcutaneous fat tissue limit emergency percutaneous cricothyrotomy?
Authors: Sanak Tomasz , Chukwu Ositadima , Gabryś Anna , Giliavas Jakub , Ciuk Katarzyna , Kalek Marta , Urbanik Andrzej
Published: November 2021

Background

Needle cricothyrotomy is a method of maintaining airways in emergency situations. One of identified factors that can make this procedure difficult to perform is ‘difficult neck anatomy’ or short obese neck. Due to the growing problem of obesity, we decided to estimate feasibility of needle cricothyrotomy by measuring the thickness of neck fat tissue in the population. Evaluation of this method is important because it is the only method that can be legally performed by paramedics in Poland. The aim of the study was to estimate feasibility of needle cricoidectomy by evaluating the percentage of population in which the thickness of subcutaneous fat tissue could potentially limit or complicate such a procedure.
Methods

In this retrospective study we reviewed CT scans of the neck from a database at the Department of Radiology, University Hospital in Cracow. 550 CT scans met inclusion criteria: age of patient over 18 years old, lack of any lesions altering anatomy of measured region of neck, the first CT scan of patient. 50.36% of patients were women. Median age was 61 years (range 18 – 93). The distance from the skin surface at the level of the lower edge of the thyroid cartilage to the cricothyroid ligament (surface - ligament distance, SLD) was measured. Statistical analysis of the data was performed using R software (R version 4.0.3).
Results

Median SLD was 1.41 (1.01 - 2.04). Subcutaneous fat tissue was thicker than maximal depth of application of cricothyrotomy (3cm) device in 31 patients (5.64%).
Conclusions

Performing needle cricothyrotomy may be limited in a considerable percentage of population (5.64%).
Research Involvement Among Undergraduate Health Profession Students in a Resource-Limited Setting: Awareness, Attitude, Motivators and Barriers
Authors: Kiyimba Blaise , Atulinda Linda , Nalunkuma Racheal , Asasira Ignatius , Kabunga Jonathan , Banturaki Davis , Nabyonga Anastacia Ssebbowa , Nakiganda Rachael , Ndyabawe Rachael , Nkalubo Jonathan , Ssewante Nelson , Bongomin Felix , Bakeera-Kitaka Sabrina
Published: November 2021

Background: Involvement of undergraduate health professions students (HPS) in research will facilitate evidence-based clinical practice among future healthcare partitioners. This study aimed to assess research involvement of undergraduate students and associated factors in Uganda.Methods: A cross-sectional study was conducted using an online assessment tool sent through WhatsApp groups and E-mail addresses of HPS in 12 medical schools in Uganda between 20th September and 5th October 2021.Results: We enrolled 398 participants with a mean age of 23.9±3.7 years. Of this, 267 (67.1%) were male. One hundred twenty (30.2%) participants previously participated in a research activity: 90 (58.4%) as research assistants, 39 (25.3%) published as first authors, and 25 (16.2%) as co-authors. Training on the conduct of research was received by242 (65.8%) participants, and 326 (81.9%) had intentions of conducting research in the future. Factors influencing participation in research activities were, age ³ 25 years (adjusted odds ratio (aOR): 1.9, 95% confidence interval (95% CI): 1.2‑3.2, p=0.012), being male (aOR: 2.1, 95%CI: 1.2 - 3.6, p=0.008), and being in a clinical year i.e., year 3 (aOR: 3.2, 95% CI: 1.1 -9.3, p=0.033), year 4 (aOR: 3.3, 95% CI: 1.1 - 9.5, p=0.028) and year 5(aOR: 11.6, 95% CI: 3.2 - 42.1, p<0.001). Lack of funds (79.6%), and mentorship (63.3%) were reported as major barriers to research.Conclusions: Despite a high proportion of HPS showing interest in getting involved in research, less than one-third reported previous involvement. Addressing barriers such as funding could potentially improve research involvement and output among undergraduate HPS in resource-limited settings.
Synthesis, Characterization and Adsorption of Bisphenol A Using Novel Hybrid Materiel Produced from PANI Matrix Reinforced by Kieselguhr
Authors: Ouis Dalila , Kebir Abdelkader El , Moulefera Imane , Sabantina Lilia , Abdelghani Benyoucef
Published: November 2021

This study investigated the preparation of new adsorbent based PANI and Kieselguhr (KG). The produced materials were characterized by XRD, XPS, TEM, FTIR, TGA and BET. Thereby, hybrid material PANI@KG highest SBET values (about 47.82 m2.g−1). The adsorption capacity of the PANI, KG and PANI@KG were tested on BPA ions from aqueous solutions at ambient temperature and pH 6.0, the maximum capacity of adsorption was observed to be 63.68 mg.g−1 which is obtained from Langmuir adsorption isotherm by hybrid adsorbent PANI@KG. Besides, the pseudo-2nd order kinetics was more consistent with the obtained experimental data. Furthermore, the hybrid material possessed highest adsorption capacity after six cycles of adsorption-desorption process. Moreover above 80% of removal percentage was obtained even after three recycles. Hence we expect that this organic-inorganic adsorbent can be selected as a potential candidate for water treatment.
Sea Level controls on Agulhas Leakage Salinity and the Atlantic Overturning Circulation
Authors: Nuber Sophie , Rae James , Andersen Morten , Zhang Xu , de Boer Bas , Dumont Matthew , Sun Yuchen , Mithan Huw , Hall Ian , Barker Stephen
Published: November 2021

The Indian Ocean has been proposed as an important source of salt for North Atlantic deep-water convection sites, via the Agulhas Leakage, and may thus drive changes in the ocean’s overturning circulation. However, while past changes in Agulhas leakage volume have been explored, little is known about this water’s salt content, representing a major gap in our understanding of Agulhas salinity supply. Here, we present new planktonic foraminiferal Mg/Ca-derived sea surface temperatures (SST) and stable isotope-derived salinity reconstructions for the last 1.2Ma from the western Indian Ocean source waters of the Agulhas Leakage to investigate glacial-interglacial changes in surface water properties. We find that SST and relative salinity both increase during glaciation, leading to high salinity and SST during glacial maxima. We show that the onset of surface salinification and warming in the Indian Ocean occurs during a phase of rapid land-bridge exposure in the Indonesian archipelago induced by sea level lowering. We link these findings to new global climate model results which show that the export of salt from the Indian Ocean via the Agulhas Leakage can directly impact the deglacial Atlantic meridional overturning circulation and therefore global climate.
Patient Care Ownership in Medical Students: A Validation Study
Authors: Wyatt Tasha R. , Wood Elena A. , Waller Jennifer L. , Egan Sarah C. , Stepleman Lara M.
Published: November 2021

Background: Psychological Ownership is the cognitive-affective state individuals experience when they come to feel they own something. The construct is context-dependent reliant on what is being owned and by whom. In medical education, this feeling translates to what has been described as “Patient Care Ownership,” which includes the feelings of responsibility that physicians have for patient care. The construct was originally validated with business employees, then recently translated into residency education where ownership behavior is expected. We adapted this instrument for a medical student population where patient ownership skills begin.Methods: Guiding our validation study was Downing’s framework, which combines theory, predicted relationships, and empirical evidence to propose the use of newly created instruments. Downing argues that assessments are not valid in and of themselves; they are the result of researchers’ evidence gathered in support of a specific interpretation. We chose to adapt this instrument because, like employees who feel that various projects belong to them, physicians share similar feelings about patients and their care. Results: The results show that the initial subscales proposed by Avey et al. (i.e. Territoriality, Accountability, Belongingness, Self-efficacy, and Self-identification) did not account for item responses in the revised instrument when administered to medical students. Instead, four subscales (Team Inclusion, Accountability, Territoriality, and Self-Confidence) better described patient care ownership for medical students, and the internal reliability of these subscales was found to be good. Using Cronbach’s alpha, the internal consistency among items for each subscale, includes: Team Inclusion (.91), Accountability (.78), Territoriality (.78), and Self-Confidence (.82). The subscales of Territoriality, Team Inclusion, and Self-Confidence were negatively correlated with the 1-item Burnout measure (P=0.01). The Team Inclusion subscale strongly correlated with the Teamwork Assessment Scale (TSA), while the subscales of Accountability correlated weakly, and Self-Confidence and Territoriality correlated moderately.Conclusions: Our study provides strong preliminary validity evidence for an adapted version of Avey et al.’s psychological ownership survey, specifically designed to measure patient care ownership in a medical student population. We expect this revised instrument to be a valuable tool to medical educators evaluating and monitoring students as they learn how to engage in patient care ownership.
Extraterrestrial Photosynthesis by Chang’E-5 Lunar Soil
Authors: Yao Yingfang , Wang Lu , Zhu Xi , Tu Wenguang , Zhou Yong , Liu Rulin , Tao Bo , Wang Cheng , Yu Xiwen , Gao Linfeng , Cao Yuan , Wang Bing , Li Zhaosheng , Yao Wei , Yang Mengfei , Zou Zhigang , Sun junchuan
Published: November 2021

In light of significant effort conducted to manned deep space exploration, it is of high technological importance and scientific interest to develop the lunar life supporting system for long-term exploration and exploitation. And lunar in situ resource utilization offers great opportunity to provide the material basis of life supporting for lunar habitation and traveling. Based on the analysis of the structure and composition, the Chang’E-5 lunar soil sample was used for lunar-surface solar energy conversion, i.e. the extraterrestrial photosynthesis catalysts. By evaluating the performance of the Chang’E-5 lunar sample as photovoltaic-driven electrocatalyst, photocatalyst and photothermal catalysts, the full water splitting and CO2 conversion are able to be achieved with solar energy, water and lunar soil, with a wide range of product distribution, including O2, H2, CO, CH4 and CH3OH. Thus, we propose a potentially available extraterrestrial photosynthesis pathway on the moon, which could help us to achieve a ‘zero-energy consumption’ environment and life support system on the moon.
Inhibition of hemozoin-induced neuroinflammation by medicinal plants used for the treatment of malaria in Southwest Nigeria: implications for cerebral malaria
Authors: Olajide Olumayokun , Iwuanyanwu Victoria
Published: November 2021

This study aimed to investigate some antimalarial plants for effects on neuroinflammation. Freeze-dried infusions of the plants were investigated for effects on hemozoin-induced neuroinflammation in BV-2 microglia and levels of inflammatory mediators measured. Alstonia boonei (stem bark), Anacardium occidentale (stem bark), Azadiractha indica (leaves), Enantia chlorantha (stem bark), Khaya senegalensis (stem bark), Mangifera indica (stem bark), and Nauclea latifolia (stem bark) produced significant (p<0.05) reduction in TNFa, IL-6, IL-1β, MCP-1, RANTES and iNOS/NO production in BV-2 microglia stimulated with a synthetic hemozoin (400 µg/mL). Further experiments showed that pre-treatment with 50 µg/mL of A. boonei, A. indica, A. occidentale, E. chlorantha and M. indica prior to hemozoin stimulation resulted in inhibition of NF-kB activation by >40%, while E. chlorantha, K. senegalensis and N. latifolia produced weak activities. Pre‑treatment with A. indica (50 µg/mL) produced the highest inhibition (58.6%) of hemozoin-induced increased NLRP3 protein expression, while A. occidentale (50 µg/mL), M. indica (50 µg/mL) and A. boonei (50 µg/mL) reduced expression by 54.1%, 49.2% and 47.1%, respectively. Hemozoin-induced increased caspase-1 activity was reduced by A. boonei, A. occidentale, A. indica, E. chlorantha, and M. indica. These results suggest that A. boonei, A. occidentale, A. indica and M. indica produced strong inhibition of hemozoin-induced neuroinflammation through mechanisms involving NF‑kB and NLRP3 inflammasome activation, while moderate activities were produced by E. chlorantha, K. senegalensis and N. latifolia. The outcome of the study provides pharmacological evidence for the potential benefits of the plants as herbal treatments of cerebral malaria symptoms.
Implications of Fasting Plasma Glucose Variability on the Risk of Incident Peripheral Artery Disease in a Population without Diabetes: A Nationwide Population-Based Cohort Study
Authors: Chung Hye Soo , Hwang Soon Young , Kim Jung A , Roh Eun , Yoo Hye Jin , Baik Sei Hyun , Kim Nan Hee , Seo Ji A , Kim Sin Gon , Kim Nam Hoon , Choi Kyung Mook
Published: November 2021

Background
Diabetes have been known as a traditional risk factor of developing peripheral artery disease (PAD). However, the impact of long-term glycemic variability on the risk of developing PAD, especially in a general population without diabetes.
Methods
We included 152,931 individuals without diabetes from the Korean National Health Insurance Service–Health Screening Cohort. Fasting plasma glucose (FPG) variability was measured using coefficient variance (FPG-CV), standard deviation (FPG-SD), and variability independent of the mean (FPG-VIM).
Results
A total of 16,863 (11.0%) incident cases of PAD were identified during a median follow-up of 8.3 years. Kaplan–Meier curves showed a progressively increasing risk of PAD in the higher quartile group of FPG variability than in the lowest quartile group (log rank P <0.001). Multivariable Cox proportional hazard analysis showed the hazard ratio for PAD prevalence as 1.11 (95% CI 1.07–1.16, P <0.001) in the highest FPG-CV quartile than in the lowest FPG-CV quartile after adjusting for confounding variables, including mean FPG. Similar degree of association was shown in the FPG-SD and FPG-VIM. In sensitivity analysis, the association between FPG variability and the risk of developing PAD persisted even after the participants were excluded based on previously diagnosed diseases, including stroke, coronary artery disease, congestive heart failure, chronic kidney disease, or current smokers or drinkers. Subgroup analysis demonstrated that the effects of FPG variability on the risk of PAD were more powerful in subgroups of younger age, regular exercisers, and those with higher income.
Conclusion
Increased long-term glycemic variability may have a significant prognostic effect for incident PAD in individuals without diabetes.
Extending Validation of a Social Emotional Health Measure For Middle School Students
Authors: Furlong Michael J. , Paz Jennica , Carter Delwin , Dowdy Erin , Nylund-Gibson Karen
Published: November 2021

Heightened by the global Covid-19 pandemic, awareness of the need to monitor youths’ social and emotional health increased. The Social Emotional Health Survey-Secondary-2020 (SEHS-S-2020) is a well-tested option for assessing student social emotional health and promoting mental health prevention, intervention, and multitiered systems of support efforts in schools. While a growing body of literature supports the SEHS-S-2020 measure for assessing student covitality, there is less validation evidence specifically for middle school-aged adolescents (Grades 6-8 in the U.S.). The present study aimed to fill this gap in the literature by examining its use for younger adolescents. Study participants included 9,426 students from 32 counties in California located across urban, suburban, and rural communities and 414 students in Grades 6-8 (ages 11-13 years) from two middle schools. Data analyses examined structural validity, internal consistency, measurement invariance, criterion validity, predictive validity, and response stability. Results indicate excellent fit indices for a four-level higher-order measurement model, with strong concurrent and one-year predictive validity coefficients, providing support for using the SEHS-S-2020 measure for use among young adolescents in middle school settings. The discussion focuses on implications for assessing students’ psychosocial assets and universal school-based screening during this crucial developmental transition .
Malawian Higher Education: towards a more internationalized system.
Authors: Banda Lazarus Obed Livingstone , Jin Liu , Munthali George N. Chidimba , Zhou Wen Hui , Mbughi Colleen , Kayembe Helex , Banda Jane Thokozani , Ngulube Peter , Enbeyle Wegayehu
Published: November 2021

Aim: This study investigated the intentions, opportunities, and barriers to engaging in a meaningful internationalization of higher education in Malawi. Methods: This was cross-sectional research that was done between June and October 2021. Using a purposive (judgmental) sampling, we recruited 212 respondents from various institutions of higher education in Malawi. Multilinear regression analysis was used to analyze the factors with the P-value set at 0.05 level of statistical significance. Results: The results indicated that the majority of the respondents were males (63.7%) who fell into 30 years age bracket. Further, the results from the multilinear regression analysis indicate that Institutional collaboration (ß=0.326, p=0.000, CI=0.27—0.383), clear Policy on Mobility (ß=0.146, p=0.0.004, CI=0.047-0.246), experience (ß=0.083, p=0.117, CI=-0.021-0.186), academic rank (ß=0.114, p=0.000, CI=0.069-0.159) were positively statistically significant variables, whereas on the other hand, Occupation (ß=-0.131, p=0.002, CI=-0.213-0.49), academic qualification (ß=-0.106, p=0.013, CI=-0.19-0.023 and mobilityImportance (ß=-0.116, p=0.022, CI=-0.215-0.017) were negatively significant variables respectively. Conclusion and Recommendations: institutions need to invest in international and inter-institutional collaboration, clarify policy direction regarding academic mobility, keep track and linkages with mobile faculty, create a conducive social and formal institutional culture that attracts back mobile faculty, and reduce staff turnover.
Is Anti-HMGB1 Antibody a Potential Characteristic Autoantibody for Sjögren's Syndrome?
Authors: Chen Mingkun , Zhou Yi , Xue Miao , Zhu Rongrong , Jing Liling , Lin Liling , He Chengwen , Qin Yanghua
Published: November 2021

BACKGROUND: Sjögren's syndrome (SS) is a common chronic inflammatory autoimmune disease, affects about 0.33% to 0.77% population in China. The positive for antinuclear antibodies (ANA) is one of the key features of SS, which show typical granular pattern in indirect immunofluorescent antibody test (IIFT). About 70% SS patients have the anti-SS-A and/or SS-B antibodies, which indicates other autoantibodies in SS patients.METHODS: The anti-HMGB1 antibody in 93 SS patients and 96 healthy controls were investigated with in-house built ELISA and immunoblotting; and the location of HMGB1 and fluorescent pattern of anti-HMGB1 antibody were investigated with IIFT. The contribution of anti-HMGB1 antibody in ANA-IF was evaluated with Cas9-induce HMGB1 knockout B16 cells.RESULTS: The anti-HMGB1 antibody in SS patients (9.96±5.55 VS 4.9±1.4 RU/ml RU/ml compared to healthy controls) increased. With ROC curve analysis, when taking 8 RU/ml as the cutoff value, the sensitivity, specificity, and the area under the curve were 64.5%, 96.9% and 0.83, respectively. A total of 18 patients (20.7%) with granular pattern in ANA-IF test were anti-HMGB1 antibody positive only. With commercial antibody, the fluorescent pattern of anti-HMGB1 antibody showed typical granular pattern. The serum from ANA-IF (+), SS-A (-), and SS-B (-) SS patients showed typical granular pattern in wildtype B16 cells, but no fluorescence in HMGB1 knockout B16 cells.CONCLUSIONS: Anti-HMGB1 antibody may be one of the characteristic autoantibodies of SS except anti-SS-A and SS-B. The detection of anti-HMGB1 antibody can provide more laboratory evidence for clinical diagnosis of SS.
WITHDRAWN: Curved Diffraction Patterns of 2D-Cross-Grating Experiments---Double Slit Still Has Much to Offer
Authors: peng hui
Published: November 2021

Young’s double slit experiments represent the mystery of quantum mechanics. To explore the mystery, varieties of the single slit, double slit, cross-double slit and 1D-grating experiments were performed, which show the universal phenomena that the interference/diffraction patterns are curved, expanded and inclined. In this article, we show novel phenomena that the diffraction patterns of the 2D-cross-grating experiments can be curved, expanded and inclined simultaneously and continuously. Those experiments provide comprehensive data for developing/testing a theoretical model.
Occupational Related Upper and Low Back Pain Among Working Population of Ethiopia: Systematic Review and Meta-Analysis
Authors: Mengistu Dechasa Adare , Demmu Yohannes Mulugeta , Alemu Addisu
Published: November 2021

Background: Back pain such as low and upper back pains are among the most common disabling musculoskeletal conditions that can cause a major public health and socio-economic problems. Back pain is one of the leading causes of disability that reduces worker performance, well-being, and increase absence from work, which can cause an enormous economic burden. In developing countries, particularly in Ethiopia, there is no adequate evidence on the overall prevalence of occupational-related low and upper back pains and remain less prioritized and empirically unrepresented. Therefore, this study aimed to determine the prevalence of occupational-related low and upper back pains among the working population of Ethiopia.Methods: This systematic review and meta-analysis considered studies conducted in Ethiopia, written in English language, and published from 2017-2020. Articles were searched from nine electronic databases (Web of Science, SCOPUS, PubMed, Google Scholar, CINAHL, Cochrane Library, African Index Medicus, African Journals Online database and Science Direct) using a combination of Boolean logic operators, Medical Subject Headings and main keywords. The quality assessment of the articles was performed using Joanna Briggs Institute Critical Appraisal tools to determine the relevance of the articles to the study. A random effects model was used to estimate the pooled prevalence, 95% confidence interval, and the degree of heterogeneity among the included studies. Sensitivity analyses were performed to identify the influence of outliers and to identify the sources of heterogeneity.Results: Of the 1,114 studies identified from the included databases, 20 studies were included in the systematic review and meta-analysis. The pooled prevalence of occupational-related upper and low back pain in the previous year was 27.1% [95% CI: 18.4, 37.9] and 54.2% [95% CI: 48.2, 60.0], respectively. Based on a subgroup analysis by publication year, study population and countries where the studies are conducted, the prevalence of upper back pain was 43.8% [95% CI: 39.3, 47.7], 34.7% [95% CI: 33.1, 36.2] and 36.2% [95% CI: 33.6, 39.0], respectively, while the prevalence of low back pain was 61.8% [95% CI: 58.9, 64.6], 52.8% [95% CI: 51.3, 54.3] and 55.2% [95% CI: 51.4, 59.0], respectively.Conclusions: This systematic review and meta-analysis found that more than half of the included study participants experienced low back pain in the previous year, while more than one-fourth experienced upper back pain. Therefore, implementation of engineering and administrative controls, modifying individual factors, ergonomics, physical examinations and identifying risk factors can reduce back pains.
Treatment of Impetigo with Antiseptics- Replacing Antibiotics (TIARA) Trial- a single blind randomised controlled trial in school health clinics within socioeconomically disadvantaged communities in New Zealand
Authors: Primhak Sarah , Gataua Alicia , Purvis Diana , Thomp John MD , Walker Cameron , Best Emma , Leversha Alison
Published: November 2021

BackgroundImpetigo is a common and contagious bacterial skin infection, affecting children worldwide but it is particularly prevalent in deprived communities. In New Zealand widespread prescribing of the topical antibiotic fusidic acid had led to an increase in antimicrobial resistance of Staphylococcus aureus. Alternative treatments are urgently being sought and as impetigo is a superficial infection, it has been suggested that topical antiseptics such as hydrogen peroxide or simple wound care alone may treat impetigo while avoiding the risk of increased antimicrobial resistance.MethodsThis protocol for a non-inferiority, single-blind randomised controlled trial compares topical fusidic acid with topical hydrogen peroxide and with simple wound care in the treatment of childhood impetigo. Participants are randomised to one of the three treatments for five days and the primary outcome is clinical improvement. This is assessed through paired photographs analysed by graders blinded to treatment arm. The trial is based in school health clinics in an urban centre in New Zealand. Comparison of antimicrobial resistance patterns pre- and post-treatment is also performed.DiscussionSpecial note is made of the need to involve the communities most affected by impetigo in the design and implementation of the clinical trial in order to recruit the children most in need of safe and effective treatments.Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR) 12616000356460
Dental pulp stem cells as a therapy for congenital entero-neuropathy
Authors: Yoshimaru Koichiro , Yamaza Takayoshi , Kajioka Shunichi , Sonoda Soichiro , Yanagi Yusuke , Matsuura Toshiharu , Yoshizumi Junko , Oda Yoshinao , Iwata Naoko , Takai Chiho , Nakayama Shinsuke , Taguchi Tomoaki
Published: November 2021

Hirschsprung’s disease is a congenital entero-neuropathy that causes chronic constipation and intestinal obstruction. New treatments for entero-neuropathy are needed because current surgical strategies have limitations5. Entero-neuropathy results from enteric nervous system dysfunction due to incomplete colonization of the distal intestine by neural crest-derived cells. Impaired cooperation between the enteric nervous system and intestinal pacemaker cells may also contribute to entero-neuropathy. Stem cell therapy to repair these multiple defects represents a novel treatment approach. Dental pulp stem cells derived from deciduous teeth (dDPSCs) are multipotent cranial neural crest-derived cells, but it remains unknown whether dDPSCs have potential as a new therapy for entero-neuropathy. Here we show that intravenous transplantation of dDPSCs into the Japanese Fancy-1 mouse, an established model of hypoganglionosis and entero-neuropathy, improves large intestinal structure and function and prolongs survival. Intravenously injected dDPSCs migrate to affected regions of the intestine through interactions between stromal cell-derived factor-1α and C-X-C chemokine receptor type-4. Transplanted dDPSCs differentiate into both pacemaker cells and enteric neurons in the proximal colon to improve electrical and peristaltic activity. Our findings indicate that transplanted dDPSCs can differentiate into different cell types to correct entero-neuropathy-associated defects.
A theory of viscoelastic crack growth-Revisited
Authors: Schapery Richard A
Published: November 2021

A theory of viscoelastic crack growth developed nearly five decades ago is generalized to express traction in the so-called fracture process zone or failure zone as a function of the crack opening displacement (COD). In earlier work, except for minor exceptions, traction was specified as a function of location. The new model leads to a nonlinear double integral that has to be solved for the COD before crack growth can be predicted. First, a closed-form, accurate approximation is found for a linear elastic body. We then show that this COD may be easily and accurately extended to linear viscoelasticity using a realistic, broad spectrum creep compliance. An analytical relationship connecting the stress intensity factor to crack speed then follows. Consistent with earlier work, it is defined almost entirely by the creep compliance. Five different failure zone tractions are employed; their differences are shown to have little effect on crack growth other than through a speed shift factor. The Appendix discusses initiation of growth.
A Novel Depreciation Approach in an Uncertain Environment: Interval Type-2 Fuzzy Sets in Maritime
Authors: AKAN Ercan , KİRACI Kasım
Published: November 2021

This study aims to propose a novel model for the determination of depreciation in an environment of uncertainty. In the study, amortization methods were revised through Interval Type-2 Fuzzy (IT2FSs), and a new approach was proposed for investors to make decisions in an environment of cash flow is uncertainty. In the study, we provide options among different depreciation alternatives in the future investment decisions of maritime companies through the revision of the straight-line depreciation method and the double-declining balance depreciation method. The fuzzy depreciation alternatives we suggest in our study are not only suitable for maritime companies, but also companies in different industries.
Low adherence to pneumococcal vaccination in lung cancer patients in a tertiary care university hospital in Southern Germany
Authors: Mohr Arno , Kloos Mia , Schulz Christian , Pfeifer Michael , Salzberger Bernd , Bauernfeind Stilla , Hitzenbichler Florian , Plentz Annelie , Koch Myriam
Published: November 2021

IntroductionThe aim of this study was to investigate the adherence to vaccinations, especially pneumococcal vaccinations, in lung cancer patients.MethodsThe study was performed at the University Hospital Regensburg, Germany. All patients with a regular appointment scheduled between December 1, 2020, and April 29, 2021, and who provided informed consent were included. Available medical records, vaccination certificates and a questionnaire were analyzed.Results136 lung cancer patients (NSCLC n = 113, 83.1%, SCLC n = 23, 16.9%) were included. A correct pneumococcal vaccination according to national recommendations was performed in 9.4% (12/127) of patients.A correct vaccination was performed for tetanus in 50.4% (6/131), diphtheria in 34.4% (44/128), poliomyelitis in 25.8% (33/128), tick-borne encephalitis in 40.7% (24/59), hepatitis A in 45.5% (7/11), hepatitis B in 38.5% (5/13), shingles in 3.0% (3/101), measles in 50.0% (3/6), pertussis in 47.7% (62/130), influenza in 54.4% (74/136) and meningococcal meningitis in 0% (0/2).ConclusionAdherence to pneumococcal vaccinations, as well as other vaccinations, is rather low in lung cancer patients.
Efficacy of Subtenon 20-mg Triamcinolone Injection Versus 0.1% Dexamethasone Eye Drops For Controlling Inflammation After Phacoemulsification: A Randomized Controlled Trial
Authors: Choopong Pitipol , Taetrongchit Nuttacha , Boonsopon Sutasinee , Nimkarn Atchariya , Srisukkosa Kanyapag , Chonpimai Pratuangsri , Nujoi Waree , Maneephagaphun Krissana , Panyayingyong Noppakhun , Tesavibul Nattaporn
Published: November 2021

A prospective randomized control trial of 140 eyes from 140 patients, who underwent phacoemulsification, was conducted to compare the efficacy of subtenon corticosteroids injection with corticosteroids eye drops for controlling postoperative intraocular inflammation. Seventy patients received subtenon 20-mg triamcinolone injection (TA group), whereas the other 70 patients received 0.1% dexamethasone eye drops (Dexa group) after the uneventful surgeries. We examined and measured anterior chamber inflammation (ACI) score, laser flare-cell metering, conjunctival redness, pain, discomfort, visual acuity, intraocular pressure, and central foveal thickness on 1, 7, 14, 28 and 90 days postoperatively. At one month after the surgery, full recovery (zero ACI score) was found in 43 patients (63.20%) in the Dexa group versus 47 patients (68.10%) in the TA group (p=0.55). There were no statistically differences in aqueous cells (p=0.37) and flare (p=0.86) between the two groups at one month. All participants experienced no serious adverse events. In conclusion, we found no statistically significant difference between subtenon 20-mg triamcinolone injection and 0.1% dexamethasone eye drop to control inflammation postoperatively. A single subtenon 20-mg triamcinolone injection could be an alternative anti-inflammatory treatment for an uneventful phacoemulsification.