bluuebunny/crossref_metadata_2025 huggingface dataset:
ЩОДО ГЛИБИННИХ ВИКЛИКІВ НОВОЇ РЕАЛЬНОСТІ ТА БУДУВАННЯ ЖИТТЄЗДАТНОЇ МОДЕЛІ УПРАВЛІННЯ НАЦІОНАЛЬНОЮ КОМПАНІЄЮ: ПРИНЦИПОВІ ПОЛОЖЕННЯ НА ГРУНТІ СОЦІОКУЛЬТУРНОЇ ПАРАДИГМИ (НА ПРИКЛАДІ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ)
Authors: Компанієць В. В.
Published: June 2023

В статті проаналізовані глибинні зміни в глобальній соціально-економічній системі, напрямки і фактори успішного управління в кризовій ситуації та роботи компаній в нових умовах. Доведено необхідність формування моделі управління залізничним транспортом України, що буде адекватною культурному коду та ситуації у зовнішньому середовищі, як одну з головних умов  життєздатності національної компанії в новій реальності. Охарактеризовано модель управління, яка історично склалась у межах православної цивілізації. Встановлено, що цій моделі інновації сучасного західного менеджменту, спрямовані на забезпечення успішної роботи компаній в нових умовах, були притаманні  внутрішньо. Але відповідна модель мала іншу світоглядну основу, цілі, цінності. Доведено, що подолання кризи та подальший розвиток залізничного транспорту – функція бажання керівників змінити власну свідомість, психологічну модель  управління та власну поведінку.
ОСОБЛИВОСТІ УПРАВЛІННЯ ДОСВІДОМ КЛІЄНТІВ ПІДПРИЄМСТВ В УМОВАХ ЦИФРОВІЗАЦІЇ
Authors: Обруч Г. В. , Бережний І. О. , Гавадзюк Є. Б.
Published: June 2023

Встановлено, що в «епоху клієнта» ключовими факторами успішного розвитку бізнесу є формування унікального сервісу та позитивного клієнтського досвіду в кожній точці взаємодії споживача з компанією і впровадження цифрових технологій управління клієнтським досвідом. Досліджено фактори, які формують враження клієнта і впливають на якість управління споживчим досвідом. Доведено доцільність перегляду принципів управління взаємовідносинами зі споживачами на основі провадження політики клієнтоцентричного мислення, адаптації бізнес-моделі розвитку компанії до нових трендів клієнтської поведінки, забезпечення цифрової трансформації клієнтського сервісу. Акцентовано увагу на врахуванні таких ключових трендів клієнтської поведінки при управлінні  споживчим досвідом, як забезпечення «безшовного» характеру комунікації клієнтів з компанією і надання їм персоналізованого сервісу. Доведено, що ефективними інструментами управління клієнтським досвідом є рішення у сфері проєктування досвіду клієнтів, метрики оцінювання ефективності взаємодії споживачів з компанією, нові підходи до формування маркетингової політики та інструменти digital-маркетингу.
ОСОБЛИВОСТІ ФІНАНСОВОГО МЕНЕДЖМЕНТУ В ОРГАНІЗАЦІЯХ МАЛОГО БІЗНЕСУ
Authors: Петрикова О. С.
Published: June 2023

Малий бізнес – один із наріжних каменів життєздатної економіки. Ця форма діяльності створює найкращі можливості для підприємництва та творчості. Оскільки для малого бізнесу знаходиться місце на ринку, він розширюється, підтримуючи конкуренцію, що веде до збільшення продуктивності та реального  економічного зростання. Головним критерієм сучасної системи  управління є забезпечення  ефективності та  конкурентоспроможності роботи підприємства. Це особливо важливо для підприємств малого бізнесу, де без дотримання цих умов важко  розраховувати на успіх. Основною метою фінансового менеджменту підприємств малого бізнесу є забезпечення безперебійної стійкої виробничо-господарської діяльності для досягнення максимального прибутку і підвищення  конкурентоспроможності  господарюючого суб'єкта. Правильний вибір стилю і методів фінансового управління дозволять малому підприємству домогтися довготривалих позитивних результатів і зайняти стійке положення на ринку.
Adaptability and Forage Productivity of Panicum phragmitoides Stapf. in the Southern Region
Authors: Gerard O.K. , Koutouan F.P. , Bodji N.C. , Yao N.R.
Published: June 2023

Background: Adaptability and forage productivity of Panicum phragmitoïdes in the humid region of Côte d’Ivoire were evaluated compared to Panicum maximum cv C1 from October 2018 to April 2019. Methods: Three accessions of P. phragmitoïdes and P. maximum cv C1 were transplanted by cuttings with three replicates in a randomized complete blocks design to evaluate adaptability parameters and forage yield. Result: The average number of tallies per tuft of P. phragmitoïdes ranged from 15.83±2.24 to 19.17±7.39 versus 33.67±5.10 tallies for P. maximum cv C1. Accessions of P. phragmitoïdes ranged in height from 146.33±9.49 to 151.42±15.88 cm and were higher than P. maximum cv C1 which was 119.50±20.67 cm. The forage productivity of P. phragmitoïdes and P. maximum cv C1. were identical and ranged from 4.84±1.07 to 8.20±3.72 t DM/ha/year. P. phragmitoïdes seems to adapt well in the humid region of Côte d’Ivoire.
Narratives of occupational therapy students from the Philippines on virtual internship
Authors: Comia Gwyneth , Manalo Jan Ericka , Areglado Hanna Patricia , Rivera Zaira Claudine , Delos Reyes Rod Charlie
Published: June 2023

Virtual internships became an alternative work-based learning for the continuity of education affected by the pandemic. This transition made an impact on the internship experience of Filipino students, particularly the occupational therapy students in delivering services. Occupational therapy (OT) is a client-centered profession that focuses on the therapeutic use of activities in treating impairments that hinder an individual’s occupational participation. This study aims to explore experiences of OT interns from CALABARZON, a region in the Philippines during virtual internships. A phenomenological study approach was utilized. Six (6) OT interns from different universities in CALABARZON participated in a focus group discussion via ZOOM video conferencing platform. Data collected were recorded, transcribed, and analyzed through thematic analysis. Five themes emerged: (1) preparation to virtual internship through bridging programs; (2) positive experiences, attitudes, and practices in virtual internship; (3) perceived advantages and disadvantages of virtual internship; (4) challenges and additional demands in virtual internship; and (5) preview of real occupational therapy through virtual internship.
Kuzey Makedonya’da Kurban İbadetine Dair Uygulamalar
Authors: OKUR Hüseyin
Published: June 2023

Kuzey Makedonya, Osmanlı Devleti’nin uzun yıllar egemenliğinde kalmış bir bölgedir (1389-1913). Osmanlı, coğrafi ve kültürel yakınlık sebebiyle fethedilen diğer yerlerden daha çok Balkanlarla ilgilenmiştir. Bunun neticesinde de özellikle demografi, sosyal hayat, ekonomi ve kültür alanlarında Osmanlı tecrübesi büyük ve zengin bir miras bırakmıştır. Bunlardan biri kurban ibadetidir. Kurban, sosyal yönü olan bir ibadettir. Balkanlarda günümüzde de uygulanmaya devam eden kurban, başta sahip olduğu ibadet olma vasfı ve insanları birleştirici özelliğinden ötürü, müslüman ve hatta gayr-i müslimlerin değer verdiği sosyal bir olgudur. Kurban ibadeti sadece kurban bayramına mahsus olmadığından doğum, ölüm, adak, şükür gibi çeşitli vesilelerle bir ritüel olarak da bölgede varlığını sürdürmüştür. Bu çalışmada İslam’ın şiarı olarak kabul edilen kurban ibadetinin, Makedonya ve çevresinde nasıl uygulandığı; bir taraftan kaynaklara başvurarak, diğer taraftan bölgede tarafımızdan gerçekleştirilen gözlem ve röportajlardan elde edilen verilerle incelenecektir.
El disco de Newton en el Traité de physique de Ganot y el discurso de la objetividad mecánica. La difusión de un patrón demostrativo entre 1900 y 1936 en la enseñanza secundaria y universitaria
Authors: Guijarro Mora Víctor , González de la Lastra Leonor
Published: June 2023

El “disco de Newton” se transformó por medio del Traité élémentaire de physique de Adolphe Ganot, publicado por primera vez en 1851, en la demostración estándar y completa de la recomposición de la luz blanca, cerrándose así el círculo argumen tativo iniciado con el experimento del prisma sobre su descomposición. Pero los resultados no eran concluyentes: más que el color blanco se veían tonos agrisados y, además, ¿eran los colores los que se mezclaban o eran nuestras sensaciones? En este estudio, atendiendo a los diferentes elementos que componen la demostración (los textuales, iconográficos y materiales) se reconstruye el relato que mantuvo protegida la comprobación de las interpretaciones personales y subjetivas. De esta manera se obtuvo un discurso convincente por su sencillez y reproducibilidad, que se mantuvo en el primer tercio del siglo XX en centros españoles de educación secundaria y universitaria a pesar de que su valor probatorio real fuera dudoso.
Building Peace Through Qur’anic Interpretation in Muslim Communities in the Post-Conflict West Kalimantan
Authors: Syarif Syarif , Herlambang Saifuddin
Published: June 2023

This study explores building peace in post-conflict areas in the West Kalimantan area, Indonesia, especially among Muslim communities that had experienced ethnic conflict in 1999. This qualitative research with a phenomenological approach observes and conducts in-depth interviews with the Muslim community, both ethnic Malay Sambas and ethnic Madurese. In addition, the author also conducted interviews with several religious leaders in West Kalimantan. This study found that there are still few religious leaders who carry out conflict resolution through contextual interpretation of the Qur’an in accordance with social conditions in West Kalimantan. In principle, West Kalimantan has an opportunity to become an area of tolerance, especially in the post-ethnic conflict area of Sambas. With the characteristics of a moderate Muslim society, social interaction between ethnicities, and genealogically the Ulama in West Kalimantan conveying moderate Islamic messages, the West Kalimantan area has the potential to become a peaceful area following the conflict. However, all elements of government, education, and religious leaders must synergize with each other in building peace in West Kalimantan. The role of religious leaders in ethnic conflicts is indispensable, especially since religious leaders have charismatic authority that is easy for their followers to follow. Therefore, religious leaders must deliver messages of peace through their charismatic authority.
TARİHSEL SÜREÇTE BEDEN KÜLTÜRÜNÜN OYUNCULUK SANATI ÜZERİNDEKİ ETKİSİ
Authors: ERGÜVEN Mustafa
Published: June 2023

Bu makale; Antik Yunandan günümüze, beden kültürünün ve bedene yönelik yaklaşımların oyunculuk sanatı

üzerindeki etkisini araştırmayı amaçlamıştır. Birinci bölümde; Antik Yunan ve Roma uygarlıklarındaki ideal

beden ile tragedya-komedya oyun türlerinin gerektirdiği oyunculuk biçimlerine; ikinci bölümde, Ortaçağ

Hıristiyan düşüncesinin otoritesi altında şekillenen ve devamında Rönesans ile farklılaşma gösteren beden

algısıyla kilise oyunlarına; üçüncü bölümde, Aydınlanma’nın bir sonucu olarak sağlıklı yaşama bilinci ve

spor kültürü çerçevesinde gelişim gösteren beden ile bu dönemdeki oyunculuk yaklaşımlarına; dördüncü

bölümde, 20. Yüzyıl tüketim toplumunun yarattığı beden kültürü ve oyunculuk arayışlarına değinilmiştir.

Sonuç bölümündeyse toplanan bulgular analiz edilmiş, beden kültürü ve oyunculuk sanatının hangi

noktalarda paralellik gösterdiği, beden-oyunculuk ilişkisi bağlamında değerlendirilmiştir.
TASARIMDA GERÇEKLİK VE HAKİKAT KAVRAMLARI
Authors: GÜNEŞ Serkan
Published: June 2023

Tasarım alanının temel amacı nesnel gerçeklik ile yüzleşmek, varlık hakkında hakikatleri keşfetmek ve
kurgusal yeni hakikatleri içerdikleri yeni olanaklar dahilinde tesis etmektir. Tüm tasarım süreçleri gerçekliğin
birer taklidi, temsili veya hakikat önermesi vasfında sunumu halindedir. Tasarım faaliyeti hakikati arayış
sırasında dili ile kurmaca bir gerçeklik sunar ve ürüne ait varoluşun gerekçelerini anlatır ve önerir. Tasarım
için hakikat, var olanın kaba bir taklidinde öte, kognivist özneye bir önerme halinde sunulan nesneleştirici
aklın bir işlevidir. Bu işlev, ekonomik-sosyal-politik durum ve koşullar altında, tasarım söylemleri ile
gerçekliğin doğası arasındaki ilişkinin farklı tutumlar halinde ortaya çıkmasına sebep olur.
Bu çalışma kapsamında, öncelikle gerçeklik ve hakikat kavramları tasarım bağlamında ele alınacak,
ilerleyen bölümlerde tasarımcıların hakikat tesisinde sahip oldukları özgürlük ve kısıtları ile üstlendikleri
rol ve sorumlulukları tartışılacaktır. Çalışma, tasarımcıların hakikat tesisine dönük olası tutumların neler
olabileceğine ve nasıl olmaları gerektiğine ilişkin tespit ve değerlendirmeler ile son bulmaktadır
LACAN BAĞLAMINDA RESİM VE PSİKANALİZ (Salvador Dali’nin Narcissus’un Metamorfozu, Michelangelo Merisi Da Caravaggio’nun İshak’ın Kurban Edilişi, Jackson Pollock’un - Bir (Numara 31) isimli yapıtları üzerinden bir analiz)
Authors: KAÇMAZ Zülküf
Published: June 2023

Araştırmamızda, psikanaliz ile sanatın birleştiği yer olan insanın ruhsal yapısında saklı kalmış deneyimlerin

sanat yapıtındaki gösterenleri ele alınmıştır. Konunun incelenmesinde Salvador Dali’nin Narcissus’un

Metamorfozu, Michelangelo Merisi Da Caravaggio’nun İshak’ın Kurban Edilişi ve Jackson Pollock’un Bir

(Numara 31) isimli eserleri yer almıştır. Bu eserleri meydana getiren ruhsal dünyadaki etkenler çözümlenmiştir.

Eser, sanatçı tarafından icra edilirken uygulanan kompozisyon, hareket, renk, biçim, üslup, konu gibi ögeler

incelenmiş; bu ögelerin tercih edilmesine sebep olan ruhsal dünyada saklı kalmış deneyimlerin eserdeki

gösterenleri yorumlanmıştır. Konuyla ilişkisi bakımından insanın ruhsal dünyasını etkileyen faktörler;

Lacan’ın kuramına göre “imgesel”, “simgesel” ve “gerçek” düzende ele alınmıştır. Buradan hareketle çocukluk

yaşantılarının ruhsal dünyaya etkisi incelenerek sanat eserlerindeki iz düşümleri açıklanmıştır. Ayrıca Jacques

Lacan’ın ifade ettiği öteki’nin bakışı, objet petit a, arzu nesnesi, bakış, Baba’nın yasası, kastrasyon, kaygı, korku,

skoptik dürtü, tukhe ve automaton gibi kavramların ruhsal dünyadaki yansımaları yukarıda adı geçen sanat

eserlerinde bulunan gösterenler üzerinden analiz edilmiştir. Sonuç olarak psikanalizin çözümlemek istediği

konuyu sanatın eser aracılığıyla anlattığı ifade edilmiştir.
Estudios de intervención para optimizar el rendimiento en músicos: estudio bibliométrico
Authors: López González José
Published: June 2023

El estado de la cuestión sobre intervenciones para optimizar las habilidades cognitivas y comportamentales de la práctica musical revela que éstas podrían fundamentarse en el aprendizaje autorregulado, el entrenamiento en habilidades psicológicas y mindfulness como componente metacognitivo. El objetivo del estudio fue identificar y analizar la producción científica que aborda este tema. Para ello, se realizó un estudio bibliométrico con metadatos relativos a la producción, así como otros que muestran la evolución temática de las investigaciones. El período analizado fue del año 2000 a septiembre de 2021. Los resultados indican que es un campo de interés y dinamismo entre las disciplinas de la psicología y la práctica musical, aunque en vías de crecimiento.
Kanser Hastalarında Akdeniz Diyetine Uyumun İnflamasyon ve Nüks Üzerine Olan Etkisi
Authors: ONDER Arif Hakan , SEREMET KÜRKLÜ Nilgün
Published: June 2023

Sistemik inflamasyon ve oksidatif stresin kanserin gelişimi ve ilerlemesi üzerine etkisi olduğu bilinmektedir. Akdeniz diyetinin kanser üzerine olan etkisinin bu parametreler üzerinden olduğunu gösteren bazı çalışmışalar bulunsa da bu ilişki hale net olarak belirlenememiştir. Bu nedenle bu çalışmanın amacı, kanser hastalarında Akdeniz diyetine uyum ile sistemik İnflamasyon belirteçleriyle olan ilişkiyi ortaya koymak ve bu hastalardaki nüks veya progresyon üzerine olan etkisini incelemekti. Bu amaçla Mart 2021 ile Mayıs 2021 tarihleri arasında takip ve tedavi Sağlık Bilimleri Üniversitesi Antalya Eğitim Araştırma Hastanesi Tıbbi Onkoloji Bilim Dalı polikliniğine başvuran 102 kanser hastası değerlendirilmiştir. Hastalar aktif onkolojik tedavi alıp almamasına göre ayrılmıştır. Akdeniz diyetine uyum; Akdeniz diyeti bağlılık ölçeği ([Mediterranean Diet Adherence Screener (MEDAS)] anketi ile değerlendirilmiştir. Hastaların inflamasyon durumlarının değerlendirilmesinde ise sistemik inflamasyon indeksi ve HALP skoru kullanılmıştır. Ayrıca inflamasyon ve nüks sonuçlarına etki edebilecek Charlson Komorbidite indeksi de hastalarda değerlendirilmiştir. Hastalarda tedavi almayan gruptaki bireylerin MEDAS skor ortalamasının (7.4±2.41) tedavi alan gruptaki bireylerin MEDAS skor ortalamasına (6.3±1.78) göre anlamlı düzeyde yüksek olduğu saptanmıştır (p<0.05). İnflamasyon belirteçler üzerine yapılan analizde ise Akdeniz diyetine uyum sağlamayan bireylerin Akdeniz diyetine uyum sağlayan bireylere göre C-reaktif protein (CRP) düzeyleri ve Sİİ skorları daha yüksek, HALP skorlarının ise daha düşük olduğu saptanmıştır (p<0.05). Yapılan univariate ve multivariate analizler sonucunca CRP (OR 0.97, %95 CI 0.95-0.99, p=0.006) ve nüks varlığı (OR 0.07, %95 CI 0.01-0.45, p=0.005) diğer faktörlerden bağımsız olarak Akdeniz diyetiyle ilişkili olarak saptanmıştır. Sonuç olarak çalışmamızda Akdeniz diyetine uyumun bir inflamasyon belirteci olan CRP ile ve nihayetinde hastalığın nüks veya progresyonu ile ters ilişki olduğu gösterilmiştir.
The evolving role of DNA damage response in overcoming therapeutic resistance in ovarian cancer
Authors: Bouberhan Sara , Bar-Peled Liron , Matoba Yusuke , Mazina Varvara , Philp Lauren , Rueda Bo R.
Published: June 2023

Epithelial ovarian cancer (EOC) is treated in the first-line setting with combined platinum and taxane chemotherapy, often followed by a maintenance poly (ADP-ribose) polymerase inhibitor (PARPi). Responses to first-line treatment are frequent. For many patients, however, responses are suboptimal or short-lived. Over the last several years, multiple new classes of agents targeting DNA damage response (DDR) mechanisms have advanced through clinical development. In this review, we explore the preclinical rationale for the use of ATR inhibitors, CHK1 inhibitors, and WEE1 inhibitors, emphasizing their application to chemotherapy-resistant and PARPi-resistant ovarian cancer. We also present an overview of the clinical development of the leading drugs in each of these classes, emphasizing the rationale for monotherapy and combination therapy approaches.
Indonesian news classification application with named entity recognition approach
Authors: Nurchim Nurchim , Nurmalitasari Nurmalitasari , Long Zalizah Awang
Published: June 2023

Nowadays, many netizens search for news via search engines with countless amounts of information, so it is increasingly difficult to determine when the number of news articles that appear changes very quickly and dynamically. Thus, it is necessary to process the extraction of news information to display the core information of the news. Problems arise, especially in Indonesian, which has a structure of various noun phrase entities with shallow parsing or grammatical induction. Named Entity Recognition (NER) has the opportunity to overcome this because it can extract news entities in depth, starting from proper nouns in text documents containing information search, machine translation, answering questions, and automatic summarization. This study aims to apply NER in Indonesian language news classification. This study uses Design-Based Research whose process includes (1) pre-implementation, (2) design, (3) implementation and revision, and finally, (4) reflection and evaluation. This application was developed on the platform python, streamlit, BeautifulSoup, gnews, and spacy library. The results of application accuracy testing have an F1-score value of 89.69% for all entities consisting of place, figure, day, date, and organization.
Cell-type-specific neuroproteomics of synapses
Authors: Yim Yun Young , Nestler Eric J.
Published: June 2023

In the last two decades, our knowledge of synaptic proteomes and their relationship to normal brain function and neuropsychiatric disorders has been expanding rapidly through the use of more powerful neuroproteomic approaches. However, mass spectrometry (MS) based neuroproteomic studies of synapses still need cell-type, spatial, and temporal proteome information. With the advancement of sample preparation and MS techniques, we have just begun to identify and understand proteomes within a given cell type, subcellular compartment, and cell-type-specific synapse. Here, we review the progress and limitations of MS-based neuroproteomics of synapses in the mammalian CNS and highlight the recent applications of these approaches in studying neuropsychiatric disorders such as major depressive disorder and substance use disorders. Combining neuroproteomic findings with other omics studies can generate an in-depth, comprehensive map of synaptic proteomes and possibly identify new therapeutic targets and biomarkers of several central nervous system disorders.
Disintegrin-like Protein Strategy to Inhibit Aggressive Triple Negative Breast Cancer
Authors: Limam Inès , Abdelkarim Mohamed , El Ayeb Mohamed , Crepin Michel , Marrakchi Naziha , Di Benedetto Mélanie
Published: June 2023

Venoms are a rich source of bioactive compounds, and among them is leberagin-C (Leb-C), a disintegrin-like protein derived from the venom Macrovipera lebetina transmediterrannea snakes. Leb-C has shown promising inhibitory effects on platelet aggregation. Previous studies have demonstrated that this SECD protein specifically targets α5β1, αvβ3 and αvβ6 integrins through a mimic mechanism of RGD disintegrins. In our current study, we focused on exploring the potential effects of Leb-C on metastatic breast cancer. Our findings revealed that Leb-C disrupted the adhesion, migration, and invasion capabilities of MDA-MB-231 breast cancer cells and its highly metastatic D3H2LN sub-population. Additionally, we observed significant suppression of adhesion, migration, and invasion of Human Umbilical Vein Endothelial Cells (HUVECs). Furthermore, Leb-C demonstrated a strong inhibitory effect on fibroblast growth factor 2-induced proliferation of HUVEC. We conducted in vivo experiments using nude mice and found that treatment with 2 µM of Leb-C resulted in a remarkable 73% reduction in D3H2LN xenograft tumor size. Additionally, quantification of intratumor microvessels revealed a 50 % reduction in tumor angiogenesis in xenograft after 21 days of twice-weekly treatment with 2 µM of Leb-C. Collectively, these findings suggest the potential utility of this dinsintegrin-like protein for inhibiting aggressive and resistant metastatic breast cancer.
Septin 9 Orients Apico-Basal Polarity Axis and Controls Plasticity Signals
Authors: CAI Ting ting , Peng Juan , Omrane Mohyeddine , Benzoubir Nassima , Samuel Didier , Gassama-Diagne Ama
Published: June 2023

The cytoskeleton is a master organizer of cell cortex, organelles positioning and membrane trafficking. Therefore, playing a decisive role in establishment of apico-basal polarity. Septins are critical cytoskeleton components which function in apico-basal polarity remain weakly investigated. Here, using 3D culture system, we demonstrate that septin9 localizes at basolateral membrane (BM). Its depletion induces an inverted polarity phenotype, decreasing -catenin at BM and increasing the expression of the transforming growth factor (TGF) and the epithelial-to-mesenchymal transition (EMT) markers. Similar effects were observed upon deleting its two polybasic domains, and the mutant become cytoplasmic and apical. The cysts with an inverted polarity phenotype display an invasive phenotype, with src and cortactin accumulating at the peripheric membrane. Inhibition of TGF-receptor and RhoA rescues the polarized phenotype. Although the cysts from overexpressed-septin 9, overgrowth and present a filled lumen. Both phenotypes correspond to tumor features. This suggests that septin 9 expression and assembly through the two PB domains are essential for establishing and maintaining apico-basal polarity against tumor development through a mechanism involving TGF-dependent EMT and RhoA activity.
Sex Differences In Glomerular Lesions, Atherosclerosis Progression, And In The Response To Angiotensin-Converting Enzyme Inhibitors In The Apoe-/- Mice Model
Authors: Mallén Adrián , Rodriguez-Urquia Ronny , Alvarez Rafael , Dorca-Duch Eduard , Navarro Estanis , Hueso Miguel
Published: June 2023

Background: This study analyzes sex-based differences in renal structure and response to the Angiotensin-Converting Enzyme (ACE) inhibitor enalapril in a mouse model of atherosclerosis. Methods: ApoE-/- mice (8 weeks old) received enalapril (5 mg/kg/day, subcutaneous) or PBS as a control for an additional 14 weeks. Each group consisted of six males and six females. Results: Females exhibited elevated LDL-cholesterol levels, while males presented higher creatinine levels and proteinuria. Enalapril effectively reduced blood pressure in both groups, but proteinuria decreased significantly only in females. Plaque size analysis and assessment of kidney inflammation revealed no significant sex-based differences. However, males displayed more severe glomerular injury, with increased mesangial expansion, mesangiolysis, glomerular foam cells and activated parietal epithelial cells (PECs). Enalapril mitigated mesangial expansion, glomerular inflammation (particularly in females), and the hypertrophy of PECs in males. Conclusion: This study demonstrates sex-based differences in the response to enalapril in a mouse model of atherosclerosis. Males exhibited more severe glomerular injury, while enalapril provided renal protection, particularly in females. These findings suggest potential sex-specific considerations for ACE inhibitor therapy in chronic kidney disease and atherosclerosis cardiovascular disease. Further research is needed to elucidate the underlying mechanism behind these observations.
Menstrual-Related Disturbances Following SARS-CoV-2 Vaccination: A Spanish Retrospective Observational Study in Formerly Menstruating Women
Authors: Gónzalez María , Al-Adib Miriam , Rodríguez Ana Beatriz , Carrasco Cristina
Published: June 2023

To date, the impact of COVID-19 vaccination on formerly menstruating women remains unknown. For this reason, a retrospective observational cross-sectional study was conducted (N= 548) using an online survey. General characteristics, medical history, and adverse events following COVID-19 vaccination were recorded. In comparison with the first dose, significantly higher percentages of respondents experienced menstrual-related disturbances (dose 1: 38.5% vs. dose 2: 44.8%; McNemar=9.15; mid P-value=0.002), as well as the simultaneous occurrence of two or more of these symptoms (dose 1: 11.2% vs. dose 2: 15.3%; McNemar=13.53; mid P-value=0.044) after receiving the second one. Among them, those related with the length and flow stand out, being of long-term nature in about 17-20% of cases. Interindividual factors influencing this unexpected event after receiving the dose 1 may include weight (AOR 1.02, CI 95% 1.01–1.03, P<.001), perimenopause (AOR 2.28, CI 95% 1.37–3.77, P=.001), pre-existing diagnoses of non-autoimmune rheumatic/articular conditions (AOR 0.31, CI 95% 0.10–1.00, P=0.05), hormonal contraceptive use (AOR 0.25, CI 95% 0.07-0.82, P=0.02), suffering from other vaccine side effects − such as arm pain (AOR 0.61, CI 95% 0.39–0.95, P=0.03), headache (AOR 0.53, CI 95% 0.35 – 0.80, P=.003), swollen glands (AOR 0.29, CI 95% 0.15 – 0.60, P=.001) and nauseas (AOR 0.35, CI 95% 0.14 – 0.86, P=0.02) – and the number of previous pregnancies (AOR 2.70, CI 95% 1.54 – 4.76, P=.001). Formerly menstruating women may experience long-term menstrual-related disturbances following COVID-19 vaccination.
Exploring the Potential Energy Surface of Medium-Sized Aromatic Polycyclic Systems with Embedded Planar Tetracoordinate Carbons: A Guided Approach
Authors: Inostroza Diego , Leyva-Parra Luis , Yañez Osvaldo , Cooksy Andrew L. , Thimmakondu Venkatesan S. , Tiznado William
Published: June 2023

This study scrutinizes the complexities of designing and exploring the potential energy surface (PES) of systems containing more than twenty atoms with planar tetracoordinate carbons (ptCs). To tackle this issue, we utilized an established design rule to design a Naphtho [1,2-b:4,3-b′:5,6-b′′:8,7-b′′′]tetrathiophene derivative computationally. This process began with substituting S atoms with CH– units, then replacing three sequential protons with two Si2+ units in the resultant polycyclic aromatic hydrocarbon polyanion. Despite not representing the global minimum, the newly designed Si8C22 system with four ptCs provided valuable insights into strategic design and PES exploration. Our results underscore the importance of employing adequate methodologies to confirm the stability of newly designed molecular structures containing planar hypercoordinate carbons.
New Conditions in Heart Transplantation in Persistence of SARS-CoV-2
Authors: Mitrofanova Lubov , Makarov Igor , Gorshkov Andrey , Vorobeva Olga , Simonenko Maria , Starshinova Anna , Kudlay Dmitry , Karonova Tatiana
Published: June 2023

Heart transplantation is a treatment of choice for patients with severe heart failure. Infection transmission from a donor to a recipient remains a prominent problem in organ transplantation. However, the risk of SARS-CoV-2 transmission through nonlung organ transplantation is still unclear. In the article we present a case of a 28-year-old pregnant woman who developed heart failure soon after recovery from SARS-CoV-2 infection in the third trimester of gestation. In the postpartum period the disease worsened and the patient required cardiac transplantation. We examined the recipient's heart and diagnosed left ventricular noncompaction cardiomyopathy. Immunohistochemical analysis showed the SARS-CoV-2 antigen expression in the donor’s heart before transplantation and after the surgery the endomyocardial biopsy was taken. Moreover, an ultrastructural assessment of the endomyocardial specimen revealed endothelial and pericyte injury and single particles on the surface of endothelium consistent with SARS-CoV-2. Recent findings were associated these damages with SARS-CoV-2 infection. The present study describes the rare case of SARS-CoV-2 transmission from donor to recipient through a heart transplant and resulting in endothelial cell and pericyte activation and humoral immune response activation.
Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response
Authors: Lee Richard Sean , Sad Kirti , Fawwal Dorelle V. , Spangle Jennifer Marie
Published: June 2023

Breast cancer pathogenesis, treatment, and patient outcomes are shaped by tumor-intrinsic genomic alterations that divide breast tumors into molecular subtypes. These molecular subtypes often dictate viable therapeutic interventions, and ultimately, patient outcomes. However, heterogeneity of therapeutic response may be a result of underlying epigenetic features that may further stratify breast cancer patient outcomes. In this review we examine non-genetic mechanisms that drive functional changes to chromatin in breast cancer to contribute to cell and tumor fitness, and highlight how epigenetic activity may inform therapeutic response. We conclude by providing perspectives on the future of therapeutic targeting of epigenetic enzymes, an approach which holds untapped potential to improve breast cancer patient outcomes.
Mucosal Metabolomic Signatures in Chronic Colitis: Novel Insights into the Pathophysiology of Inflammatory Bowel Disease
Authors: Calzadilla Nathan , Qazi Aisha , Sharma Anchal , Mongan Kai , Comiskey Shane , Manne Jahnavi , Youkhana Alvin G. , Khanna Sonam , Saksena Seema , Dudeja Pradeep K. , Alrefai Waddah A. , Gill Ravinder K.
Published: June 2023

(1) Background: Inflammatory bowel diseases (IBD) involve complex interactions between genetic factors, aberrant immune activation, and gut microbial dysbiosis. While metabolomic studies have focused on feces and serum, fewer investigations have examined the intestinal mucosa despite its crucial role in metabolite absorption and transport. The current study aimed to identify novel mucosal metabolic pathways that are altered during chronic colitis and to determine microbial contributions to such changes. (2) Methods: The chronic Dextran sulfate sodium (DSS) colitis was induced for five weeks in 7-9-week-old wild-type C57BL/6J male mice followed by microbial profiling with targeted 16srRNA sequencing service. Mucosal metabolite measurements were performed by Metabolon (Morrisville, NC). The data were analyzed using the bioinformatic tools Pathview, MetOrigin, and Metaboanalyst. (3) Results: Our novel findings demonstrated increases in several host- and mi-crobe-derived purine, pyrimidine, endocannabinoid, and ceramide metabolites in colitis. Origin analysis revealed microbial-related tryptophan metabolites kynurenine, anthranilate, 5-hydroxyindoleacetate, and C-glycosyltryptophan were significantly increased in colon mucosa during chronic inflammation and strongly correlated with disease activity. (4) Conclusions: These findings offer new insights into the pathophysiology of IBD and provide novel potential targets for microbial-based therapeutics.
Sera of Rats Fed With Baicalein Showed Effective Against Dengue Virus Replication
Authors: Moghaddam Ehsan , Zandi Keivan , Lani Rafidah , Erwandi Didi , Chik Zamri , Bakar Sazaly Abu , Hassandarvish Pouya
Published: June 2023

Dengue virus (DENV) is a member of the Flaviviridae family and is responsible for the most common mosquito-borne human disease. Currently, there are no available antiviral drugs to treat DENV infections. However, certain flavonoids, including baicalein and baicalin, have demon-strated significant anti-DENV effects in vitro. This study aimed to assess the bioavailability of baicalein and its metabolite, baicalin, in the blood serum of Albino Wistar rats using the LC/MS/MS method. The in vitro activity of sera obtained from rats administered baicalein was evaluated for its anti-DENV properties using quantitative RT-PCR and the Foci Forming Reduction Assay (FFRA). The results obtained through LC/MS/MS analysis indicated that the bioavailability of baicalin in rat blood serum reached 44.20 µg/ml one hour after oral administration of baicalein. Furthermore, the sera collected from rats given baicalein exhibited a significant 78.26% inhibition of DENV-2 replication when tested against Dengue-2 using both quantitative RT-PCR and FFRA. These findings suggest that baicalein and baicalin hold promise as potential therapeutic candidates for further investigation in the development of treatments against DENV infections.
Synthesis of new Blended Formulations of Oregano-Sage Essential Oils: Chemical Characterization, Antimicrobial and Phytotoxic Activities
Authors: Elshafie Hazem S. , Camele Ippolito
Published: June 2023

There is a growing interest in a potential use of essential oils (EOs) as a possible alternative for chemical pesticides. The formulation between different EOs could maximize the single biological efficacy by synergic mechanism. The aim of the current study was to evaluate the biological activity of three prepared blended oil formulations (BOFs) derived from Origanum vulgare L. (oregano) and Salvia officinalis L. (sage) compared to each parent EO. The chemical composition of each single studied EO has been revealed using GC-MS analysis. The three BOFs have been prepared as following: i) 25% oregano EO + 25% sage EO (BOF-I); ii) 25% oregano EO + 5% sage EO (BOF-II); iii) 5% oregano EO + 25% sage EO (BOF-III). The antibacterial activity of the new BOFs has been evaluated against Bacillus megaterium, B. cereus and Xanthomonas campestris, whereas, the antifungal activity has been carried out against Botrytis cinerea, Penicillium italicum and Fusarium oxysporum. The possible phytotoxic effect of the new BOFs has been evaluated on Lepidium sativum (garden cress), Solanum lycopersicum (tomato) and Lactuca sativa (lettuce) following the seed germination and radicle elongation assay. GC-MS analysis revealed that the oregano EO composed mainly from thymol, p-cymene and carvacrol with 76.0, 5.7 and 3.2 %, respectively. Whereas, salvia EO, the GC-MS analysis showed that the relevant predominant constituents were trans-thujone and camphor with 37,9 and 13,9 %, respectively. Results demonstrated that the tested BOFs possess antimicrobial effect higher than each parent EO. In particular, BOF-II showed the highest effect against all tested bacteria. Regarding the antifungal activity, BOF-II showed the highest significant antifungal effect against all tested fungi. Results showed also that both BOF-I and BOF-III explicated a moderate effect against B. cereus and all tested fungi compared to single EOs. In addition, the three BOFs showed notable phytotoxic effect against all three tested plants, particularly BOF-I. Whereas, the single sage EO at 25% showed the lowest significant phototoxic effect indicating its possible using as natural herbicides.
Electron Mean Free Path Effect on Vortex Matter in a Superconducting Pb Island Grown on Si (111)
Authors: González Jesús , Gonzalez Jader , Duran Fernando , Salas Carlos , Gomez-Rojas Jorge
Published: June 2023

In this work we report recent theoretical calculations of a superconducting island in a strong
vortex confinement regime. The obtained results reveal the evolution of superconducting condensate
as a function of electron mean-free path (l) with the evolution of an applied magnetic field H0. The
results of this study provide an insight about the emergent superconducting properties under such
conditions, using the Ginzburg-Landau numerical simulations where spatial variation of thickness d
on island, omnipresent in these kind of structures grown on Si (111), is taken into account. These
results offer a new route to tailor superconducting circuits by using the controlled bombardment, in
order to explore the impact on vortex distribution, phase of order parameter, number of vortices, free
energy and the first H1 and second critical field H2.
Detection of SF6 Decomposition Gases by the Pristine and Fe-Doped Porphyrin Based on the First-Principles Calculations
Authors: He Xing , Dai Enrui , Xue Rou , Chang Qiaowen , Xiong Huihui , Nie Zhifeng
Published: June 2023

The development of high-performance sensing materials for detecting or removing SF6 decomposition gases is crucial for gas-insulated switchgear (GIS). In this work, the adsorption characteristics of the pristine porphyrin (Pr) and Fe-doped porphyrin (FePr) monolayers towards SF6 decomposition gases were investigated using the first-principles calculations. Additionally, the electronic properties and sensing-mechanism were also examined. The findings indicate that both Pr and FePr monolayers exhibit thermodynamic stability. The intrinsic Pr monolayer only exhibits a moderate affinity towards the SO2 molecule, however, its poor sensitivity of the Pr monolayer renders it unsuitable as the sensing-material. In contrast, the FePr monolayer exhibits favorable adsorption strength towards all five toxic gases (H2S, SO2, SOF2, SO2F2, HF). The FePr monolayer exhibits chemisorption towards SO2/SOF2 gases, Furthermore, the microscopic mechanism of gases-substrate interaction is elucidated through the analysis of charge density difference, charge transfer, and density of states. Moreover, the FePr has excellent sensitivity for H2S, SO2, SO2F2, SOF2 and HF molecules owing to the significant variations of the band gap, electrical conductivity and work function. In addition, the τ of H2S, SO2, and SOF2 is 12.6 μs, 18.5 s and 15.4 s at 298 K, respectively. Our calculated results can offer theoretical guidance for the practical application of FePr-based sensing materials to detect SF6 decompositions gases.
Structural Equation Modeling of the Marine Ecological System in Nan Wan Bay using SPSS Amos
Authors: Huang Jung-Fu , Chen Chen-Tung Arthur , Chen Meng-Hsien , Huang Shih-Lun , Hsu Pi-Yu
Published: June 2023

In order to sustain the marine environment relationship between the environmental factors and marine biota must be investigated. This study aims to study such a correlation in the adjacent waters of Nan Wan Bay, Kenting, Taiwan, and to explore the covariance of environmental factors on marine life (whether they enhance or diminish it). To achieve these objectives, factor analysis was used to identify potential latent variables that could affect the water quality of the adjacent waters, including phytoplankton (quantity), zooplankton (quantity), and fish (quantity and species). These potential variables were named based on the results of past studies and related literature. Finally, a structural equation model (SEM) was constructed to establish a marine ecological model among the potential variables. The factor analysis results revealed that nutrients, upwelling, and primary productivity are the primary factors affecting the environmental changes in the adjacent waters of Nan Wan Bay. The comprehensive SEM showed that nutrients and primary productivity significantly impact plankton. Path analysis indicated that primary productivity has the highest direct effect on the phytoplankton cluster. However, the upwelling has a low significance in its effect on phytoplankton, zooplankton, and fish clusters. Compared to the results of past related studies, the SEM proposed in this study can reflect a considerable degree of change in the waters.
MRI Image Fusion Based on Sparse Representation with Patch-based Multiple Salient Features Measurement
Authors: Hu Qiu , Cai Weiming , Xu Shuwen , Hu Shaohai
Published: June 2023

Multimodal medical image fusion is a fundamental but challenging problem in the fields of brain science research and brain disease diagnosis, and it is challenging for sparse representation (SR)-based fusion to characterize activity level with single measurement and no loss of effective information. In this paper, the Kronecker-criterion-based SR framework is applied for medical image fusion with a patch-based activity level integrating salient features of multiple domains. Inspired by the formation process of vision system, the spatial saliency is characterized by textural contrast (TC), which is composed of luminance and orientation contrasts to promote more highlighted texture information to participate in the fusion process. As substitution of the conventional l1-norm-based sparse saliency, a metric of sum of sparse salient features (SSSF) is used for promoting more significant coefficients to participate in the composition of activity level measure. The designed activity level measure is verified to be more conducive to maintain the integrity and sharpness of detailed information. Various experiments on multiple groups of clinical medical images verify the effectiveness of the proposed fusion method on both visual quality and objective assessment. Furthermore, the research work of this paper is helpful for further detection and segmentation of medical images.
Effects of Partial Replacement of Si by Al on Impact Toughness of 0.2%C-Si-Mn-Cr-B TRIP-aided Martensitic Steel
Authors: Sugimoto Koh-ichi , Nakashima Yumenori , Kobayashi Junya , Hojo Tomohiko
Published: June 2023

The effects of partial replacement of Si by Al on the microstructure, tensile properties, and Charpy impact toughness were investigated using 0.2%C-Si/Al-Mn-Cr-B TRIP-aided martensitic steels. The impact toughness was related to the microstructural and mechanical properties. The partial re-placement decreased the volume fraction of retained austenite and increased the mechanical stabil-ity, accompanied by softening and an increase in the volume fraction of the primary martensite. Resultantly, the partial replacement decreased strength and ductility. The impact absorbed energy (value) at 25 C was slightly increased by the partial replacement. The increased impact absorbed energy was mainly caused by high crack/void propagation energy due to the softened primary martensite and a small contribution of the stabilized retained austenite. The 50% shear fracture ductile-to-brittle transition temperature was marginally raised by the partial replacement. The raised transition temperature was mainly associated with an increase in a unit crack path of qua-si-cleavage/cleavage fracture.
Effects of Chemotherapy Treatment on Muscle Strength Indicators, Functional Capacity and Biopsychosocial Aspects of Women With Breast Cancer
Authors: Alves Rafael Ribeiro , Marques Vitor Alves , Silva Weder Alves da , Junior Ruffo de Freitas , Da Cruz Anderson Miguel , Del Vecchio Fabrício Boscolo , Rosa Victor Domingos Lisita , Vieira Carlos Alexandre
Published: June 2023

Background: Evidences on the effects of chemotherapy treatment cycles on measures of muscle, mental state, social and cognitive performance are scarce. Objective: To analyze the effects of chemotherapy cycles on muscle strength and activation, functional capacity, quality of life, fatigue and anxiety of women with breast cancer. Methods: Twenty-two women divided into a treatment group (n = 10; 46.6 ± 9.6 years) and control group (n = 12; 51.6 ± 7.0 years) participated in the study. Analysis of muscle performance, quality of life, fatigue and anxiety after the 2nd and 4th cycle of chemotherapy with anthracyclines and cyclophosphamide were performed in women with breast cancer (TRA) and compared to healthy women (CTR). Two-way ANOVA was used to compare the variance of the means and the significance level was set as p≤0.05. Results: Differences were found in the muscular activation of the vastus medialis between the groups at post time (p = 0.038), as well as in the sit and stand test in the baseline (p<0.001) and post moment (p<0.001). Functional capacity performance was different between baseline (p<0.001) and post-time (p<0.001) groups. Additionally, the TRA group worsened the quality of life in the domains of functional capacity (p<0.001) and limitation of physical aspects (p=0.002), besides presenting negative changes in fatigue. Conclusion: Anthracycline and cyclophosphamide chemotherapy cycles reduce muscular performance and affect biopsychosocial variables in women with breast cancer.
Retrospective Analysis of the Correlation of MSI-H/dMMR Status and Response to Therapy for Endometrial Cancer: RAME Study, a Multicenter Experience
Authors: Tuninetti Valentina , Pace Luca , Ghisoni Eleonora , Quarà Virginia , Arezzo Francesca , Palicelli Andrea , Mandato Vincenzo Dario , Geuna Elena , Cormio Gennaro , Biglia Nicoletta , Borsotti Lucia , Gallo Silvia , Ferrero Annamaria , Jacomuzzi Elena , Fuso Luca , Pezua Sanjinez Jeremy Oscar Smith , Puppo Andrea , Caglio Andrea , Rognone Chiara , Turinetto Margherita , Scotto Giulia , Di Maio Massimo , Valabrega Giorgio
Published: June 2023

Background: There is poor evidence about sensitivity to chemotherapy according to microsatellite instability (MSI)/mismatch repair (MMR) status in endometrial cancer (EC).
Methodology: The RAME study is a retrospective analysis aiming to assess response to chemotherapy in MSI-high (h) /deficient (d) MMR and MSI- low (l)/proficient (p)MMR EC patients. Primary endpoints were recurrence-free survival (RFS) for patients with localized disease and progression-free survival (PFS) and overall survival (OS) in patients with advanced/recurrent disease.
Results: 312 patients treated between 2010-2022 in 4 high volume Multicenter Italian Trial in Ovarian cancer and gynecological malignancies (MITO) centers were selected. 239 patients had endometrioid EC (76.6%), 151 had FIGO stage I at diagnosis (48.9%) and 71 were MSI-h/dMMR (22.8%). Median age was 65 (range 31–91) years. Among patients with localized disease, median RFS was 100.0 months (95%CI 59.4–140.7) for MSI-l/pMMR and 120.9 months (60.0-181.8) for MSI-h/dMMR (p=0.39). Seventy-seven patients received first-line chemotherapy for advanced/recurrent disease. Patients with MSI-h/dMMR ECs had a significantly worse OS (p=0.039). In patients receiving platinum-based chemotherapy, no statistically significant difference in PFS (p=0.21) and OS (p=0.057) were detected, although PFS and OS were numerically longer in the MSI-l/pMMR population.
Conclusion: Patients with metastatic MSI-h/dMMR EC receiving first-line chemotherapy had a significantly worse OS.