bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the mechanism of action of colchicine in the treatment of coronary artery disease based on network pharmacology and molecular docking technology
Authors: Yu Yunfeng , Zhou Manli , Long Xi , Yin Shuang , Hu Gang , Yang Xinyu , Jian Weixiong , Yu Rong
Published: June 2023

Objective: This is the first study to explore the mechanism of colchicine in treating coronary artery disease using network pharmacology and molecular docking technology, aiming to predict the key targets and main approaches of colchicine in treating coronary artery disease. It is expected to provide new ideas for research on disease mechanism and drug development.

Methods: Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Swiss Target Prediction and PharmMapper databases were used to obtain drug targets. GeneCards, Online Mendelian Inheritance in Man (OMIM), Therapeutic Target Database (TTD), DrugBank and DisGeNET databases were utilized to gain disease targets. The intersection of the two was taken to access the intersection targets of colchicine for the treatment of coronary artery disease. The Sting database was employed to analyze the protein-protein interaction network. Gene Ontology (GO) functional enrichment analysis was performed using Webgestalt database. Reactom database was applied for Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Molecular docking was simulated using AutoDock 4.2.6 and PyMOL2.4 software.

Results: A total of 70 intersecting targets of colchicine for the treatment of coronary artery disease were obtained, and there were interactions among 50 targets. GO functional enrichment analysis yielded 13 biological processes, 18 cellular components and 16 molecular functions. 549 signaling pathways were obtained by KEGG enrichment analysis. The molecular docking results of key targets were generally good.

Conclusion: Colchicine may treat coronary artery disease through targets such as Cytochrome c (CYCS), Myeloperoxidase (MPO) and Histone deacetylase 1 (HDAC1). The mechanism of action may be related to the cellular response to chemical stimulus and p75NTR-mediated negative regulation of cell cycle by SC1, which is valuable for further research exploration. However, this research still needs to be verified by experiments. Future research will explore new drugs for treating coronary artery disease from these targets.
Inhibition of Nur77 expression and translocation by compound B6 reduces ER stress and alleviates cigarette smoke-induced inflammation and injury in bronchial epithelial cells
Authors: Chang Chenli , He Fengming , Ao Mingtao , Chen Jun , Yu Tao , Li Weiyu , Li Baicun , Fang Meijuan , Yang Ting
Published: June 2023

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide with inflammation and injury in airway epithelial cells. However, few treatment options effectively reduce severity. We previously found that Nur77 is involved in lipopolysaccharide-induced inflammation and injury of lung tissue. Here, we established an in vitro model of COPD-related inflammation and injury in 16-HBE cells induced by cigarette smoke extract (CSE). In these cells, Nur77 expression and localization to the endoplasmic reticulum (ER) increased following CSE treatment, as did ER stress marker (BIP, ATF4, CHOP) expression, inflammatory cytokine expression, and apoptosis. The flavonoid derivative, named B6, which was shown to be a modulator of Nur77 in previous screen, molecular dynamics simulation revealed that B6 binds strongly to Nur77 through hydrogen bonding and hydrophobic interactions. Treating CSE-stimulated 16-HBE cells with B6 resulted in a reduction of both inflammatory cytokine expression and secretion, as well as attenuated apoptosis. Furthermore, B6 treatment resulted in a decrease in Nur77 expression and translocation to the ER, which was accompanied by a concentration-dependent reduction in the expression of ER stress markers. Meanwhile, B6 played a similar role in CSE-treated BEAS-2B cells. These combined effects suggest that B6 could inhibit inflammation and apoptosis in airway epithelial cells after cigarette smoke stimulation, and support its further development as a candidate intervention for treating COPD-related airway inflammation.
Paeoniflorin mitigates high glucose-induced lifespan reduction by inhibiting insulin signaling in Caenorhabditis elegans
Authors: Liu Tianwen , Zhuang Ziheng , Wang Dayong
Published: June 2023

In organisms, high glucose can cause several aspects of toxicity, including the lifespan reduction. Paeoniflorin is the major component of Paeoniaceae plants. Nevertheless, the possible effect of paeoniflorin to suppress high glucose toxicity in reducing lifespan and underlying mechanism are largely unclear. Thus, in this study, we examined the possible effect of paeoniflorin in suppressing high glucose (50 mM)-induced lifespan reduction and the underlying mechanism in Caenorhabditis elegans. Administration with 16–64 mg/L paeoniflorin could prolong the lifespan in glucose treated nematodes. Accompanied with this beneficial effect, in glucose treated nematodes, expressions of daf-2 encoding insulin receptor and its downstream kinase genes (age-1, akt-1, and akt-2) were decreased and expression of daf-16 encoding FOXO transcriptional factor was increased by 16–64 mg/L paeoniflorin administration. Meanwhile, the effect of paeoniflorin in extending lifespan in glucose treated nematodes was enhanced by RNAi of daf-2, age-1, akt-1, and akt-2 and inhibited by RNAi of daf-16. In glucose treated nematodes followed by paeoniflorin administration, the increased lifespan caused by daf-2 RNAi could be suppressed by RNAi of daf-16, suggesting that DAF-2 acted upstream of DAF-16 to regulate pharmacological effect of paeoniflorin. Moreover, in glucose treated nematodes followed by paeoniflorin administration, expression of sod-3 encoding mitochondrial Mn-SOD was inhibited by daf-16 RNAi, and the effect of paeoniflorin in extending lifespan in glucose treated nematodes could be suppressed by sod-3 RNAi. Molecular docking analysis indicated the binding potential of paeoniflorin with DAF-2, AGE-1, AKT-1, and AKT-2. Therefore, our results demonstrated the beneficial effect of paeoniflorin administration in inhibiting glucose-induced lifespan reduction by suppressing signaling cascade of DAF-2-AGE-1-AKT-1/2-DAF-16-SOD-3 in insulin signaling pathway.
NBCe1-B/C-knockout mice exhibit an impaired respiratory response and an enhanced renal response to metabolic acidosis
Authors: Brady Clayton T. , Marshall Aniko , Zhang Chen , Parker Mark D.
Published: June 2023

The sodium-bicarbonate cotransporter (NBCe1) has three primary variants: NBCe1-A, -B and -C. NBCe1-A is expressed in renal proximal tubules in the cortical labyrinth, where it is essential for reclaiming filtered bicarbonate, such that NBCe1-A knockout mice are congenitally acidemic. NBCe1-B and -C variants are expressed in chemosensitive regions of the brainstem, while NBCe1-B is also expressed in renal proximal tubules located in the outer medulla. Although mice lacking NBCe1-B/C (KOb/c) exhibit a normal plasma pH at baseline, the distribution of NBCe1-B/C indicates that these variants could play a role in both the rapid respiratory and slower renal responses to metabolic acidosis (MAc). Therefore, in this study we used an integrative physiologic approach to investigate the response of KOb/c mice to MAc. By means of unanesthetized whole-body plethysmography and blood-gas analysis, we demonstrate that the respiratory response to MAc (increase in minute volume, decrease in pCO2) is impaired in KOb/c mice leading to a greater severity of acidemia after 1 day of MAc. Despite this respiratory impairment, the recovery of plasma pH after 3-days of MAc remained intact in KOb/c mice. Using data gathered from mice housed in metabolic cages we demonstrate a greater elevation of renal ammonium excretion and greater downregulation of the ammonia recycling enzyme glutamine synthetase in KOb/c mice on day 2 of MAc, consistent with greater renal acid-excretion. We conclude that KOb/c mice are ultimately able to defend plasma pH during MAc, but that the integrated response is disturbed such that the burden of work shifts from the respiratory system to the kidneys, delaying the recovery of pH.
The old second messenger cAMP teams up with novel cell death mechanisms: potential translational therapeutical benefit for Alzheimer’s disease and Parkinson’s disease
Authors: Zhang Tong , Luu Minh D. A. , Dolga Amalia M. , Eisel Ulrich L. M. , Schmidt Martina
Published: June 2023

Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most prevalent neurodegenerative disorders severely impacting life expectancy and quality of life of millions of people worldwide. AD and PD exhibit both a very distinct pathophysiological disease pattern. Intriguingly, recent researches, however, implicate that overlapping mechanisms may underlie AD and PD. In AD and PD, novel cell death mechanisms, encompassing parthanatos, netosis, lysosome-dependent cell death, senescence and ferroptosis, apparently rely on the production of reactive oxygen species, and seem to be modulated by the well-known, “old” second messenger cAMP. Signaling of cAMP via PKA and Epac promotes parthanatos and induces lysosomal cell death, while signaling of cAMP via PKA inhibits netosis and cellular senescence. Additionally, PKA protects against ferroptosis, whereas Epac1 promotes ferroptosis. Here we review the most recent insights into the overlapping mechanisms between AD and PD, with a special focus on cAMP signaling and the pharmacology of cAMP signaling pathways.
Quantitative texture analysis comparison of three legumes
Authors: Miller Rebekah , Duncan Susan , Yin Yun , Zhang Bo , Lahne Jacob
Published: June 2023

A validated texture-analysis method to evaluate product quality in frozen or cooked legumes is needed to support high-quality vegetable production but is not currently established in the literature. Peas, lima beans, and edamame were investigated in this study due to similar market use as well as growth in plant-based protein consumption in the United States. These three legumes were evaluated after three different processing treatments (blanch/freeze/thaw (BFT); BFT+microwave heat (BFT+M); BF+stove-top cooking (BF+C)), using both compression and puncture analysis following an American Society of Agricultural and Biological Engineers (ASABE) texture analysis method and moisture testing following an American Society for Testing and Materials (ASTM) standard method. Texture analysis results showed differences between legumes and processing methods. Compression analysis identified more differences between treatments within product type than puncture for both edamame and lima beans indicating compression might be more sensitive to texture changes in these products. Implementation of a standard texture method for legume vegetables for growers and producers would provide a consistent quality check to support efficient production of high-quality legumes. Due to the sensitivity obtained from the compression texture method in this work, compression should be considered for future research into a robust method to evaluate edamame and lima bean textures throughout the growing and production processes.
The moderating influence of perceived government information transparency on COVID-19 pandemic information adoption on social media systems
Authors: Mensah Isaac Kofi , Khan Muhammad Khalil , Liang Juan , Zhu Nan , Lin Li-Wei , Mwakapesa Deborah Simon
Published: June 2023

Introduction

Social media systems are instrumental in the dissemination of timely COVID-19 pandemic information to the general population and contribute to the fight against the pandemic and waves of disinformation during the COVID-19 pandemic. This study uses the information adoption model (IAM) as the theoretical framework to examine the moderating influence of perceived government information transparency on the adoption of COVID-19 pandemic information on social media systems from the Ghanaian perspective. Government information transparency regarding the pandemic is crucial since any lack of transparency can negatively affect the global response to the pandemic by destroying trust (in government and public health authorities/institutions), intensifying fears, and causing destructive behaviors.

Methods

It applies a convenient sampling technique to collect the responses from 516 participants by using self-administrated questionnaires. The data analysis was computed and analyzed with SPSS-22. The following statistical tests were conducted to test the hypotheses: descriptive statistics, scale reliability test, Pearson bivariate correlation, multiple linear regressions, hierarchical regression, and slope analysis.

Results

The results indicate that information quality, information credibility, and information usefulness are significant drivers of COVID-19 pandemic information adoption on social media systems. Furthermore, the perceived government information transparency positively moderates the influence of information quality, information credibility, and information usefulness on the adoption of COVID-19 pandemic information on social media systems.

Conclusion

The theoretical and managerial implications of these findings suggest the utilization of social media systems as an effective tool to support the continued fight against the current COVID-19 pandemic and its future role in national and global public health emergencies.
Mental health in Canadian children and adolescents during COVID-19 pandemic: the role of personality and, coping and stress responses
Authors: Shokrkon Anahita , Nicoladis Elena
Published: June 2023

In December 2019, the Coronavirus Disease (COVID-19) pandemic first emerged in China and quickly spread to other countries. Previous studies have shown that the COVID-19 pandemic and the consequences have negatively impacted the mental health of adults. Individual differences such as personality could contribute to mental health. Furthermore, coping and responses to stress may affect an individual’s response to the pandemic. In the past, studies have only investigated this relationship in adults. In the current study, we examine how personality traits (using the Five-Factor Model as our framework) and Coping and Response to COVID-19 stress are related to the mental health of Canadian children and adolescents during the pandemic. Using parent reports of 100 preschoolers and 607 6–18-year-old children, we performed multiple regression analysis to explore how personality traits predict the effects of COVID-19 on mental health. The results showed that personality traits are associated with the mental health of Canadian youth during the COVID-19 pandemic. In preschoolers, Neuroticism and Agreeableness predicted the most mental health problems, and in 6-18-year-old children, Extraversion negatively predicted the most mental health problems. Also, Openness to Experience was the weakest predictor of mental health status in Canadian youth. These findings could be useful in understanding children’s responses to the COVID-19 pandemic and could assist public health services delivering mental health services specifically tailored to children’s personalities during and after this pandemic.
Discursive angles on the relationship in psychotherapy
Authors: Muntigl Peter , Scarvaglieri Claudio
Published: June 2023

Research on the psychotherapy relationship has been dominated by quantitative-statistical paradigms that focus on relationship elements and their (evidence-based) effectiveness regarding the psychotherapy process. In this mini review, we complement this existing line of research with a discursive-interactional view that focuses on how the relationship isaccomplishedbetween therapists and clients. Our review highlights some of the main studies that use micro-analytic, interactional methods to explore relationship construction of the following elements: Affiliation, cooperation (Alignment), empathy and Disaffiliation-Repair. We not only provide a summary of important discursive work that provides a unique lens onhowthe relationship may be established and maintained, but also suggest that this kind of micro-analytic approach can offer more nuanced conceptualizations of the relationship by showing how different elements work together in a synergistic manner.
Cognitive control, bedtime patterns, and testing time in female adolescent students: behavioral and neuro-electrophysiological correlates
Authors: D’Angiulli Amedeo , Byczynski Gabriel , Yeh Wei-Hsien , Garrett George , Goldfield Gary , Devenyi Peter , Devenyi Tibor , Leisman Gerry
Published: June 2023

Introduction

Shorter and/or disrupted sleep during adolescence is associated with cognitive and mental health risks, particularly in females. We explored the relationship between bedtime behavior patterns co-varying with Social Jet Lag (SJL) and School Start Times (SST) and neurocognitive performance in adolescent female students.

Methods

To investigate whether time of day (morning vs. afternoon), early SSTs and days of the school week can be correlated with neurocognitive correlates of sleep insufficiency, we recruited 24 female students aged 16–18 to report sleep logs, and undergo event-related electroencephalographic recordings on Monday, Wednesday, mornings, and afternoons. Using a Stroop task paradigm, we analyzed correlations between reaction times (RTs), accuracy, time of day, day of week, electroencephalographic data, and sleep log data to understand what relationships may exist.

Results

Participants reported a 2-h sleep phase delay and SJL. Stroop interference influenced accuracy on Monday and Wednesday similarly, with better performance in the afternoon. For RTs, the afternoon advantage was much larger on Monday than Wednesday. Midline Event-Related Potentials (ERPs) yielded higher amplitudes and shorter latencies on Wednesday morning and Monday afternoon, in time windows related to attention or response execution. A notable exception were delayed ERP latencies on Wednesday afternoon. The latter could be explained by the fact that delta EEG waves tended to be the most prominent, suggesting heightened error monitoring due to accumulating mental fatigue.

Discussion

These findings provide insights into the interaction between SJL and SST and suggest evidence-based criteria for planning when female adolescents should engage in cognitive-heavy school activities such as tests or exams.
Impact of COVID-19 on the education and healthcare services of persons with disabilities in Lebanon
Authors: Shuayb Itab , Doueiry Sabine
Published: June 2023

This study examines the impact of the compounding crises that engulfed Lebanon during the COVID-19 pandemic on the schooling and healthcare opportunities and experiences of persons with disabilities. It further explores how disability interacts with other forms of discrimination, such as gender and socioeconomic factors, exacerbating the risk of exclusion from mainstream education and healthcare services. Qualitative research methods were employed to delve into the complexities of these issues. The researchers conducted a comprehensive review of 37 relevant COVID-19 reports, research studies, guidelines, documents, and rapid analysis studies generated by the Lebanese Ministry of Public Health, local and international NGOs, and UN agencies. Additionally, analysis of social media content and COVID-19 awareness campaigns was carried out to assess their accessibility and acknowledgment of the needs of persons with disabilities (PWD). Furthermore, eighteen virtual open-ended interviews were conducted with adults with disabilities, parents of children with disabilities, local and international disability organizations, and representatives from the education and healthcare sectors. The findings from the interviews revealed that while the COVID-19 pandemic disrupted the daily routines of individuals, persons with disabilities encountered additional barriers on top of the pre-existing ones they faced before the implementation of lockdown restrictions. The study identified five overarching themes at the policy and decision levels, as well as the academic and healthcare services levels, which hindered persons with disabilities from accessing education and healthcare. Drawing from the five main themes, this study presents and discusses key findings, implications, and recommendations. These findings shed light on the challenges faced by persons with disabilities during the compounding crises and the implications for their access to education and healthcare. The study provides recommendations to address these issues and improve the opportunities and experiences of persons with disabilities in times of crisis.
The community engagement course and action network: strengthening community and academic research partnerships to advance health equity
Authors: Akintobi Tabia Henry , Barrett R. , Hoffman L. , Scott S. , Davis K. , Jones T. , Brown N. De Veauuse , Fraire M. , Fraire R. , Garner J. , Gruner A. , Hill J. , Meckel R. , Obi C. , Omunga P. , Parham Q. , Rice T. , Samples O. , Terrill T.
Published: June 2023

Background

Historically Black Colleges and Universities and Minority Serving Institutions are uniquely positioned to implement community-campus research partnerships based on a history of service, the pursuit of community trustworthiness and student demographics often similar to surrounding marginalized communities. The Morehouse School of Medicine Prevention Research Center collaborates with members of Historically Black Colleges and Universities, Minority Serving Institutes, and community organizations on the Community Engaged Course and Action Network. This network is the first of its kind and aims to strengthen members’ ability to implement Community-Based Participatory Research (CBPR) principles and partnerships. Projects address public health priorities including mental health among communities of color, zoonotic disease prevention, and urban food deserts.

Materials and methods

To assess the effectiveness of the network, a Participatory Evaluation framework was implemented to conduct process evaluation which included review of partnership structures, operations, project implementation processes, and preliminary outcomes of the research collaborations. A focus group of Community Engagement Course and Action Network members (community and academic) was also conducted to identify benefits and challenges of the network with emphasis on key areas for improvement to further enhance the relationships between partners and to facilitate their subsequent community-campus research.

Results

Network improvements were tied to themes strengthening community-academic partnerships including sharing and fellowship, coalition building and collaboration, and greater connections and awareness of community needs through their current community-academic partnerships. The need to conduct ongoing evaluation during and after implementation, for determining the early adoption of CBPR approaches was also identified.

Conclusion

Evaluation of the network’s processes, infrastructure, and operation provides early lessons learned to strengthen the network. Ongoing assessment is also essential for ensuring continuous quality improvement across partnerships such as determining CBPR fidelity, assessing partnership synergy, and dynamics, and for quality improvement of research protocol. The implications and potential for advancing implementation science through this and similar networks are great towards advancing leadership in modeling how foundations in community service can advance to CBPR partnership formation and ultimately, health equity approaches, that are local defined and assessed.
Users’ perception of the OH-EpiCap evaluation tool based on its application to nine national antimicrobial resistance surveillance systems
Authors: Moura Pedro , Collineau Lucie , Sandberg Marianne , Tomassone Laura , De Meneghi Daniele , Norström Madelaine , Bennani Houda , Häsler Barbara , Colomb-Cotinat Mélanie , Bourély Clémence , Filippitzi Maria-Eleni , Mediouni Sarah , Boriani Elena , Asaduzzaman Muhammad , Caniça Manuela , Aenishaenslin Cécile , Alban Lis
Published: June 2023

Introduction

Antimicrobial resistance (AMR) is a One Health (OH) challenge. To achieve or maintain an effective and efficient AMR surveillance system, it is crucial to evaluate its performance in meeting the proposed objectives, while complying with resource restrictions. The OH-EpiCap tool was created to evaluate the degree of compliance of hazard surveillance activities with essential OH concepts across the following dimensions: organization, operational activities, and impact of the surveillance system. We present feedback on the application of the OH-EpiCap tool from a user’s perspective, based on the use of the tool to evaluate nine national AMR surveillance systems, each with different contexts and objectives.

Methods

The OH-EpiCap was assessed using the updated CoEvalAMR methodology. This methodology allows the evaluation of the content themes and functional aspects of the tool and captures the user’s subjective experiences via a strengths, weaknesses, opportunities, and threats (SWOT) approach.

Results and Discussion

The results of the evaluation of the OH-EpiCap are presented and discussed. The OH-EpiCap is an easy-to-use tool, which can facilitate a fast macro-overview of the application of the OH concept to AMR surveillance. When used by specialists in the matter, an evaluation using OH-EpiCap can serve as a basis for the discussion of possible adaptations of AMR surveillance activities or targeting areas that may be further investigated using other evaluation tools.
Epidemiological impact of public health interventions against diabetes in Qatar: mathematical modeling analyses
Authors: Alareeki Asalah , Awad Susanne F. , Critchley Julia A. , El-Nahas Katie G. , Al-Hamaq Abdulla O. , Alyafei Salah A. , Al-Thani Mohammed H. J. , Abu-Raddad Laith J.
Published: June 2023

Aims

To predict the epidemiological impact of specific, and primarily structural public health interventions that address lifestyle, dietary, and commuting behaviors of Qataris as well as subsidies and legislation to reduce type 2 diabetes mellitus (T2DM) burden among Qataris.

Methods

A deterministic population-based mathematical model was used to investigate the impact of public health interventions on the epidemiology of T2DM among Qataris aged 20–79 years, which is the age range typically used by the International Diabetes Federation for adults. The study evaluated the impact of interventions up to 2050, a three-decade time horizon, to allow for the long-term effects of different types of interventions to materialize. The impact of each intervention was evaluated by comparing the predicted T2DM incidence and prevalence with the intervention to a counterfactual scenario without intervention. The model was parameterized using representative data and stratified by sex, age, T2DM risk factors, T2DM status, and intervention status.

Results

All intervention scenarios had an appreciable impact on reducing T2DM incidence and prevalence. A lifestyle management intervention approach, specifically applied to those who are categorized as obese and ≥35 years old, averted 9.5% of new T2DM cases by 2050. An active commuting intervention approach, specifically increasing cycling and walking, averted 8.5% of new T2DM cases by 2050. Enhancing consumption of healthy diets including fruits and vegetables, specifically a workplace intervention involving dietary modifications and an educational intervention, averted 23.2% of new T2DM cases by 2050. A subsidy and legislative intervention approach, implementing subsidies on fruits and vegetables and taxation on sugar-sweetened beverages, averted 7.4% of new T2DM cases by 2050. A least to most optimistic combination of interventions averted 22.8–46.9% of new T2DM cases by 2050, respectively.

Conclusions

Implementing a combination of individual-level and structural public health interventions is critical to prevent T2DM onset and to slow the growing T2DM epidemic in Qatar.
Prevalence and influencing factors of lower urinary tract symptoms in female nurses: a cross-sectional study based on TARGET
Authors: Zhang Xinyue , Li Mengli , Dong Wenshuo , Lv Xiaoyan , Li Li , Yang Xiaorong , Cao Yingjuan
Published: June 2023

Background

Even though occupational women have a high incidence of lower urinary tract symptoms (LUTS), which seriously affect their daily work life, few large scale sample studies have provided empirical evidence to support this phenomenon among female nurses in China. Consequently, this article investigated female nurses who was presupposed to have a high prevalence of LUTS, which adversely exposes their health and patient safety to these risks. Additionally, it is considered important to explore the factors associated with LUTS in female nurses for patient care safety and nurse bladder health practice.

Objectives

The purpose of this study was to assess the incidence of LUTS and symptoms-related risk factors among female nurses, to provide evidence for the prevention and control of LUTS.

Methods

An online survey recruiting 23,066 participants was carried out in a multicenter cross-sectional study in 42 hospitals from December 2020 to November 2022. Stepwise multivariate logistic regression analysis and nomogram were used to identify the factors associated with lower urinary tract symptoms. Besides, SPSS version 26.0, R version 4.2.2, and GraphPad Prism Version 8.3 software packages were used for statistical analysis.

Results

Based on the completion rate of the questionnaire which was 84.1% (n = 19,393), it was found that among 19,393 female nurses, the prevalence of LUTS was 67.71% and this rate was influenced by age, Body Mass Index (BMI), marital status, years of working, menstrual status, mode of delivery, history of breastfeeding, history of miscarriage, history of alcohol and coffee or tea consumption (p < 0.05). Interestingly, we also find that in addition to the above mentioned factors, anxiety, depression, and perceived stress were also related to LUTS in female nurses (p < 0.05).

Conclusion

Given the high prevalence of LUTS among female nurses and their potential influencing factors, female nurses should focus on their reproductive health and develop good lifestyle habits. Thus, nursing managers should provide a warm and harmonious work environment and sensitize female nurses to increase their awareness about the importance of drinking clean water and urinating during work in a hygienic environment.
The impact of psychological distress on quality of care and access to mental health services in cancer survivors
Authors: Abdelhadi Ola
Published: June 2023

Introduction

Psychological distress is highly prevalent among cancer survivors and significantly impacts their health outcomes. Our study aim is to examine the impact of psychological distress on the quality of care in cancer survivors.

Methods

We utilized longitudinal panels from the Medical Expenditure Panel Survey data spanning from 2016 to 2019 to estimate the impact of psychological distress on quality of care. We compared a sample of cancer survivors with psychological distress (N = 176) to a matched sample of cancer survivors without psychological distress (N = 2,814). We employed multivariable logistic regression models and Poisson regression models. In all models, we adjusted for age at the survey, sex, race/ethnicity, education, income, insurance, exercise, chronic conditions, body mass index, and smoking status. Descriptive statistics and regression models were performed using STATA software.

Results

Our findings revealed a higher prevalence of psychological distress among younger survivors, females, individuals with lower incomes, and those with public insurance. Cancer survivors with psychological distress reported more adverse patient experiences compared to those without distress. Specifically, survivors with distress had lower odds of receiving clear explanations of their care (OR: 0.40; 95% CI: 0.17–0.99) and lower odds of feeling respected in expressing their concerns (OR: 0.42; 95% CI: 0.18–0.99) by their healthcare providers. Furthermore, psychological distress was associated with increased healthcare utilization, as evidenced by a higher number of visits (p = 0.02). It also correlated with a decrease in healthcare service ratings (p = 0.01) and the affordability of mental health services (p < 0.01) for cancer survivors.

Discussion

These findings indicate that psychological distress can significantly impact the delivery of healthcare and the patient experience among cancer survivors. Our study underscores the importance of recognizing and addressing the mental health needs of cancer survivors. It provides insights for healthcare professionals and policymakers to better understand and cater to the mental health needs of this population.
Integrated food-based multi-actor approach to combat malnutrition
Authors: Yazdanpanah Masoud , Löhr Katharina , Hoffmann Harry Konrad , Welte Simone , Klaus Lisa Maria , Zobeidi Tahereh , Rybak Constance
Published: June 2023

Despite initial progress, overall development toward zero hunger is not promising. Combating all forms of malnutrition is a complex challenge that requires complex answers from the local to global scales. To support a common understanding and to develop a joint approach that adequately addresses these challenges, an expert panel discussion was organized during the “Nutrition for Growth Summit Tokyo” on (7–8) December 2021 entitled “Multi-sectoral systems approach to holistically tackle malnutrition” upon which this article is based. We highpoint the requirement for actual access to ideas that move beyond the abstract and mostly figurative acknowledgment of the importance of bringing all actors together to combat malnutrition. Four entry points for a food-based multi-sectoral system approach to holistically tackle the burden of malnutrition were agreed upon. These entry points are not discrete, single entities but rather require integrated approaches. While we argue for an integrated approach building on all four interlinked components, it is important to note that the degree of each component's integration is context-dependent and that the examples presented as possible implementation strategies do not apply to all countries alike.
Five-Year results of a multi-specialty induction course for surgical training
Authors: Kwan Jing Yi , Lainas Panagiotis , Banks Philippa , Jimenez De Veciana Anna , Said Hagar , Mehrem Anna , Debbarma Manash , Matthews Melissa , Etim Gloria , Biyani Chandra Shekhar , Rajpal Sanjay , Phillipson Mark , Palit Victor , Renwick Paul , Yiasemidou Marina
Published: June 2023

Background

The Essential Surgical Skills Course (ESSC) is a multi-specialty induction “boot camp” style course that has been run successfully for five years. The aim of the current paper is to create an accurate guide for the replication of the course by other teams and assess the course's fitness for purpose, through the survey feedback provided by trainees.

Methods

The course's fitness for purpose was assessed through cumulative five-year survey feedback from trainees. This observational study describes the design and process of content adjustment according to feedback.

Results

The course its five-year span offered twelve different procedural skills in four different specialties. Feedback for each session was persistently >8/10. Key themes identified as beneficial include teacher-to-trainee ratio (often 1:1), teaching style, course structure and responsiveness.

Conclusions

The ESSC was found to be fit for purpose for the induction of trainees into surgical training. The key factors contributing to the success of the course include the structured method of curriculum design, outstanding teaching delivery methods, teacher-to-trainee ratio, the availability of appropriate faculty and infrastructure and the willingness to learn from trainee feedback and adjust the content of the course accordingly. It acts as a paradigm for courses aimed to prepare surgical trainees for a “step-up” in their careers.
Króm- és nikkelallergiás páciens komplex protetikai ellátása
Authors: Saláta József , Hermann Péter , Ábrám Emese
Published: June 2023

Bevezetés: Napjainkban az allergiás megbetegedéssel küzdő páciensek száma folyamatosan növekszik. Szájüregipanaszokat, elváltozásokat okozhatnak fogászati fémek (leggyakrabban a nikkel és a palládium), fémötvözetek, illetvepolimerek is. Fémallergia esetén az adott anyagot tartalmazó hagyományos fogászati ötvözetek használata kontraindikált,de megfelelő alternatívát jelenthetnek többek között a teljes kerámia fogpótlások, illetve a titánvázas fogpótlások is.Esetismertetés: 46 éves nőbeteg 2019-ben jelentkezett a Semmelweis Egyetem Fogpótlástani Klinikáján hiányzófogainak pótlása céljából. A páciens eugenolra, krómra és nikkelre való allergiáját epicutan teszttel igazolta. Az alternatívanyagok alkalmazására vonatkozó aktuális szakmai ajánlásokat követve a felső állcsonton cirkónium-dioxid vázas,kerámialeplezésű szóló koronák, illetve titánvázas, kompozitleplezésű hidak készítését terveztük. Az alsó állcsontprotetikai terve olyan kombinált fogpótlás volt, melynek rögzített része titánvázas, kompozitleplezésű sín, kivehető részepedig dentomucosalis megtámasztású, rejtett elhorgonyzású, titán alaplemezű részleges lemezes fogpótlás volt. A protetikaifázist professzionális szájhigiénés kezelés, instruálás, motiválás, valamint konzerváló fogászati beavatkozásokelőzték meg.Összefoglalás: Az allergiás megbetegedések gyakorisága miatt a mindennapi fogászati ellátás során nem szabad figyelmenkívül hagynunk annak a lehetőségét, hogy páciensünk túlérzékeny lehet egyes fogászati anyagokra. Bár ezenpáciensek ellátása nagy körültekintést igényel, megfelelő indikációban alkalmazott alternatív anyagok használatávalhosszú távú sikereket tudunk elérni.
Design Investigation of Potential Long-Range Hydrogen Combustion Blended Wing Body Aircraft with Future Technologies
Authors: Karpuk Stanislav , Ma Yiyuan , Elham Ali
Published: June 2023

Present work investigates the potential of a long-range commercial blended wing body configuration powered by hydrogen combustion engines with future airframe and propulsion technologies. Future technologies include advanced materials, load alleviation techniques, boundary layer ingestion, and ultra-high bypass ratio engines. The hydrogen combustion configuration was compared to the configuration powered by kerosene with respect to geometric properties, performance characteristics, energy demand, equivalent CO2 emissions, and Direct Operating Costs. In addition, technology sensitivity studies were performed to assess the potential influence of each technology on the configuration. A multi-fidelity sizing methodology using low- and mid-fidelity methods for rapid configuration sizing was created to assess the configuration and perform robust analyses and multi-disciplinary optimizations. To assess potential uncertainties of the fidelity of aerodynamic analysis tools, high-fidelity aerodynamic analysis and optimization framework MACH-Aero was used for additional verification. Comparison of hydrogen and kerosene blended wing body aircraft showed a potential reduction of equivalent CO2 emission by 15% and 81% for blue and green hydrogen compared to the kerosene blended wing body and by 44% and 88% with respect to a conventional B777-300ER aircraft. Advancements in future technologies also significantly affect the geometric layout of aircraft. Boundary layer ingestion and ultra-high bypass ratio engines demonstrated the highest potential for fuel reduction, although both technologies conflict with each other. However, operating costs of hydrogen aircraft could establish a significant problem if pessimistic and base hydrogen price scenarios are achieved for blue and green hydrogen respectively. Finally, configurational problems featured by classical blended wing body aircraft are magnified for the hydrogen case due to the significant volume requirements to store hydrogen fuel.
Pressure Characteristics and Vortex Observation in Chiral-Symmetric Space Orthogonal Bifurcation
Authors: Fang Zixuan , Zhang Dingwei , Liu Xiaokang , Li Jingxuan , Yang Lijun , Fu Qingfei
Published: June 2023

In aerospace engine delivery systems, “one-in-two-out” bifurcation structures are commonly used for flow distribution to downstream pipelines. There are two common “one-in-two-out” bifurcation structures in aircraft engines: the planar orthogonal bifurcation and the spatial orthogonal bifurcation. By adjusting the flow supply upstream and the cross-sectional diameter downstream, the flow distribution in the two branches can be adjusted, i.e., the “splitting ratio” changes. In this paper, a dismantling and flexible experimental system is constructed to measure the pressure signals in each channel and use non-linear dynamic analysis methods to extract pressure characteristics. The particle image velocimetry (PIV) technique combined with the fine rope tracing technique is creatively used to observe the vortex structure in the cross section of the downstream branch. The study found that for spatial orthogonal bifurcation, the pressure signal characteristics in each channel are basically the same at larger splitting ratios, regardless of the chirality. As the splitting ratio decreases, the difference in pressure signal characteristics between the two branches gradually becomes evident and becomes related to the chirality. Moreover, unlike the planar orthogonal bifurcation structure, a complete large vortex structure has not been found in the downstream branch of the spatial orthogonal bifurcation structure, regardless of changes in the splitting ratio, and it is unrelated to the chirality.
Performance of an Automatic Variable-Rate Fertilization System Subject to Different Initial Field Water Conditions and Fertilizer Doses in Paddy Fields
Authors: Wang Haiyu , Xu Junzeng , Chen Bing , Li Yawei , Li Shuai , Liang Hao , Jiang Qianjing , He Yong , Xi Wenjia
Published: June 2023

High-performance fertilization equipment with high uniformity is essential for the improvement of fertilizer use efficiency in paddies. The performance of these fertigation systems might be affected by the initial field conditions and fertilizer doses. In this study, the uniformity of fertilization by an automatic system (SF) was investigated; the investigation had two initial field water conditions and fertilizer doses, and manual fertilization by farmers (FF) was used as the control. After fertilization, the Christiansen uniformity coefficient (CU) in the SF paddies was higher than in the FF paddies, and the SF in the non-flooded paddies (SFN) was the highest. With time, the CU of treatments with poor fertilization uniformity was improved; it was driven by the osmotic potential of fertilizer ions, but it was far from exceeding that of the treatments originally conducted with higher CU. For the SF treatments, the fertilizer dose did not affect fertilization uniformity significantly; so, an SF can match the efficient fertilization strategies more precisely. As water-saving irrigation (WSI) is conducive to the production of non-flooded field conditions and the promotion of the efficient use of topdressing, the use of automatic fertilization systems to implement efficient fertilization management practices in WSI paddy fields is suggested.
Comparing Inception V3, VGG 16, VGG 19, CNN, and ResNet 50: A Case Study on Early Detection of a Rice Disease
Authors: Shah Syed Rehan , Qadri Salman , Bibi Hadia , Shah Syed Muhammad Waqas , Sharif Muhammad Imran , Marinello Francesco
Published: June 2023

Rice production has faced numerous challenges in recent years, and traditional methods are still being used to detect rice diseases. This research project developed an automated rice blast disease diagnosis technique based on deep learning, image processing, and transfer learning with pre-trained models such as Inception V3, VGG16, VGG19, and ResNet50. The public dataset consists of 2000 images; about 1200 images belong to the leaf blast class, and 800 to the healthy leaf class. The modified connection-skipping ResNet 50 had the highest accuracy of 99.75% with a loss rate of 0.33, while the other models achieved 98.16%, 98.47%, and 98.56%, respectively. Furthermore, ResNet 50 achieved a validation accuracy of 99.69%, precision of 99.50%, F1-score of 99.70, and AUC of 99.83%. In conclusion, the study demonstrated a superior performance and disease prediction using the Gradio web application.
Effect of Upstream Bioactivation of Plant Residues to Accelerate the Composting Process and Improve Product Quality
Authors: Martínez-Gallardo María R. , Estrella-González María J. , Suárez-Estrella Francisca , López-González Juan A. , Jurado Macarena M. , Toribio Ana J. , López María J.
Published: June 2023

Composting is considered an efficient and environmentally friendly alternative for plant waste management, resulting in compost, a high value-added product. During the process, microorganisms play a crucial role as organic matter-degrading agents. However, the highly recalcitrant nature of the lignocellulose present in plant residues sets a challenge to the microorganisms involved in the process. Therefore, the objective of this study was to evaluate the effect of a lignocellulolytic microbial consortium, previously selected in composting processes, to promote and improve the biodegradability of plant residues. For this purpose, a laboratory-scale inoculation strategy was optimized by applying different strains and doses of Bacillus spp., as well as different incubation times. Subsequently, the impact of the application of the consortium on the waste material as a pretreatment of a real composting process was evaluated. Samples from both experiments were subjected to the evaluation of parameters related to the biodegradation of the lignocellulosic fraction, in addition to those related to the stability and maturity of a compost. The inoculum proved to be effective in promoting the bioactivation of the material, favoring a higher respirometric rate and biodegradability during laboratory-scale pretreatment. In this case, inoculation with B. safensis at high doses resulted in AT4 values higher than those observed for the rest of the treatments after ten days of incubation, while B. licheniformis inoculated at lower doses was able to maintain higher AT4 values after ten days, compared to those observed in the rest of the samples analyzed. Additionally, inoculation with both strains resulted in a continuous decrease in the percentage of hemicellulose that could be detected until the end of the incubation period (thirty days), reaching biodegradation rates close to 40%. On the other hand, although the inoculation did not significantly affect the basic conditioning parameters at the beginning of the composting process (organic matter, C/N ratio, and moisture), a change in the dynamics of the lignocellulosic fractions was observed during the process, as well as in the evolution of other stability and maturity parameters, in particular the AT4 index and the lignin/holocellulose ratio, revealing an acceleration of the bio-oxidative phase during the full-scale composting process. Therefore, the treatment of plant waste with lignocellulolytic microorganisms is proposed as an effective alternative to activate the biodegradability of organic waste at the beginning of a composting process, resulting in better-quality products.