bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Report: Double Pectus Up in severe pectus excavatum, the new frontier of modified taulinoplasty
Authors: Frediani Simone , Corbi Letizia , Pardi Valerio , Aloi Ivan Pietro , Bertocchini Arianna , Accinni Antonella , Reali Simone , Schingo Paolo Maria Salvatore , Inserra Alessandro
Published: May 2024

Introduction

Pectus excavatum, also known as “sunken chest” or “funnel chest,” is a congenital condition where the sternum caves inward, creating a noticeable depression in the chest. This deformity can range from mild to severe cases, and can affect appearance and lung and heart function. Treatment options vary depending on the severity of the condition and associated symptoms. A case study was conducted on three patients suffering from severe forms of pectus excavatum using modified taulinoplasty with two Pectus Up bars.

Case description

The patients were males, with an age of 15 years. Preoperatively, they underwent spirometry, an echocardiogram, and allergy tests. The procedure involved inserting two Pectus Up bars into the chest wall at the major sternal defect, allowing the implant to remain completely invisible. The procedure involved placing the sternal plate at the deepest point and anchored to the sternum with five self-tapping screws. The chest plate was then fixed to the bar using two screws.

Discussion

The use of Pectus Up was first reported in 2016 and has been a subject of scientific discussion and research. The double Pectus Up technique offers improved correction, increased stability, and reduced complications. However, it also presents challenges such as increased technical complexity and potential for prolonged operative times. Patient outcomes showed promising results in terms of short-term correction and long-term stability. The use of a double bar technique in the modified Taulinoplasty procedure is a key area of ongoing clinical research and innovation in pectus excavatum repair. Further studies will be needed, including more institutions that use this technique to validate our initial experience.
The structure and function of FUN14 domain-containing protein 1 and its contribution to cardioprotection by mediating mitophagy
Authors: Lv Yuhu , Yu Zhengze , Zhang Peiwen , Zhang Xiqian , Li Huarui , Liang Ting , Guo Yanju , Cheng Lin , Peng Fenglin
Published: May 2024

Cardiovascular disease (CVD) is a serious public health risk, and prevention and treatment efforts are urgently needed. Effective preventive and therapeutic programs for cardiovascular disease are still lacking, as the causes of CVD are varied and may be the result of a multifactorial combination. Mitophagy is a form of cell-selective autophagy, and there is increasing evidence that mitophagy is involved in cardioprotective processes. Recently, many studies have shown that FUN14 domain-containing protein 1 (FUNDC1) levels and phosphorylation status are highly associated with many diseases, including heart disease. Here, we review the structure and functions of FUNDC1 and the path-ways of its mediated mitophagy, and show that mitophagy can be effectively activated by dephosphorylation of Ser13 and Tyr18 sites, phosphorylation of Ser17 site and ubiquitination of Lys119 site in FUNDC1. By effectively activating or inhibiting excessive mitophagy, the quality of mitochondria can be effectively controlled. The main reason is that, on the one hand, improper clearance of mitochondria and accumulation of damaged mitochondria are avoided, and on the other hand, excessive mitophagy causing apoptosis is avoided, both serving to protect the heart. In addition, we explore the possible mechanisms by which FUNDC1-mediated mitophagy is involved in exercise preconditioning (EP) for cardioprotection. Finally, we also point out unresolved issues in FUNDC1 and its mediated mitophagy and give directions where further research may be needed.
One must reconstitute the functions of interest from purified proteins
Authors: Spudich James A.
Published: May 2024

I am often asked by students and younger colleagues and now by the editors of this issue to tell the history of the development of the in vitro motility assay and the dual-beam single-molecule laser trap assay for myosin-driven actin filament movement, used widely as key assays for understanding how both muscle and nonmuscle myosin molecular motors work. As for all discoveries, the history of the development of the myosin assays involves many people who are not authors of the final publications, but without whom the assays would not have been developed as they are. Also, early experiences shape how one develops ideas and experiments, and influence future discoveries in major ways. I am pleased here to trace my own path and acknowledge the many individuals involved and my early science experiences that led to the work I and my students, postdoctoral fellows, and sabbatical visitors did to develop these assays. Mentors are too often overlooked in historical descriptions of discoveries, and my story starts with those who mentored me.
Impact of maternal posture on fetal physiology in human pregnancy: a narrative review
Authors: Kember Allan J. , Anderson Jennifer L. , House Sarah C. , Reuter David G. , Goergen Craig J. , Hobson Sebastian R.
Published: May 2024

In numerous medical conditions, including pregnancy, gravity and posture interact to impact physiology and pathophysiology. Recent investigations, for example, pertaining to maternal sleeping posture during the third trimester and possible impact on fetal growth and stillbirth risk highlight the importance and potential clinical implications of the subject. In this review, we provide an extensive discussion of the impact of maternal posture on fetal physiology from conception to the postpartum period in human pregnancy. We conducted a systematic literature search of the MEDLINE database and identified 242 studies from 1991 through 2021, inclusive, that met our inclusion criteria. Herein, we provide a synthesis of the resulting literature. In the first section of the review, we group the results by the impact of maternal posture at rest on the cervix, uterus, placenta, umbilical cord, amniotic fluid, and fetus. In the second section of the review, we address the impact on fetal-related outcomes of maternal posture during various maternal activities (e.g., sleep, work, exercise), medical procedures (e.g., fertility, imaging, surgery), and labor and birth. We present the published literature, highlight gaps and discrepancies, and suggest future research opportunities and clinical practice changes. In sum, we anticipate that this review will shed light on the impact of maternal posture on fetal physiology in a manner that lends utility to researchers and clinicians who are working to improve maternal, fetal, and child health.
Interaction between ABA and NO in plants under abiotic stresses and its regulatory mechanisms
Authors: Xu Junrong , Lu Xuefang , Liu Yunzhi , Lan Weisen , Wei Zhien , Yu Wenjin , Li Changxia
Published: May 2024

Abscisic acid (ABA) and nitric oxide (NO), as unique signaling molecules, are involved in plant growth, developmental processes, and abiotic stresses. However, the interaction between ABA and NO under abiotic stresses has little been worked out at present. Therefore, this paper reviews the mechanisms of crosstalk between ABA and NO in the regulation of plants in response to environmental stresses. Firstly, ABA-NO interaction can alleviate the changes of plant morphological indexes damaged by abiotic stresses, for instance, root length, leaf area, and fresh weight. Secondly, regulatory mechanisms of interaction between ABA and NO are also summarized, such as reactive oxygen species (ROS), antioxidant enzymes, proline, flavonoids, polyamines (PAs), ascorbate-glutathione cycle, water balance, photosynthetic, stomatal movement, and post−translational modifications. Meanwhile, the relationships between ABA and NO are established. ABA regulates NO through ROS at the physiological level during the regulatory processes. At the molecular level, NO counteracts ABA through mediating post-translational modifications. Moreover, we also discuss key genes related to the antioxidant enzymes, PAs biosynthesis, ABA receptor, NO biosynthesis, and flavonoid biosynthesis that are regulated by the interaction between ABA and NO under environmental stresses. This review will provide new guiding directions for the mechanism of the crosstalk between ABA and NO to alleviate abiotic stresses.
Metabolomics analysis reveals enhanced salt tolerance in maize through exogenous Valine-Threonine-Isoleucine-Aspartic acid application
Authors: Wu Kaihua , Liang Xiaoyan , Zhang Xiu , Yang Guoping , Wang Huaxiao , Xia Yining , Ishfaq Shumila , Ji Hongfei , Qi Yuxi , Guo Wei
Published: May 2024

Salt stress is a well-known abiotic constraint that hampers crop productivity, affecting more than 424 million hectares of topsoil worldwide. Applying plant growth regulators externally has proven effective in enhancing crop resilience to salt stress. Previous metabolomics studies revealed an accumulation of Valine-Threonine-Isoleucine-Aspartic acid (VTID) in salt-stressed maize seedlings, suggesting its potential to assist maize adaptation to salt stress. To explore the effectiveness of VTID in enhancing salt tolerance in maize, 10 nM VTID was applied to salt-stressed maize seedlings. The results showed a remarkable 152.29% increase in plant height and a 122.40% increase in fresh weight compared to salt-stressed seedlings. Moreover, the addition of VTID enhanced the activity of antioxidant enzymes, specifically superoxide dismutase (SOD) and catalase (CAT), while reducing the level of malondialdehyde (MDA), a marker of oxidative stress. Additionally, VTID supplementation resulted in a significant increase in osmoregulatory substances such as proline. Metabolomic analysis revealed substantial changes in the metabolite profile of maize seedlings when treated with VTID during salt stress. Differential metabolites (DMs) analysis revealed that the identified DMs primarily belonged to lipids and lipid-like molecules. The receiver operating characteristic curve and linear regression analysis determined a correlation between isodolichantoside and the height of maize seedlings under salt-stress conditions. In conclusion, these findings validate that VTID effectively regulates tolerance in maize seedlings and offers valuable insights into the potential of short peptides for mitigating salt stress.
Water depth affects submersed macrophyte more than herbivorous snail in mesotrophic lakes
Authors: Ren Wenjing , Yao Yiqian , Gao Xiaoyu , Wang Hao , Wen Zihao , Ni Leyi , Zhang Xiaolin , Cao Te , Chou Qingchuan
Published: May 2024

Introduction

Water depth (WD) and snail abundance (SA) are two key factors affecting the growth of submersed aquatic plants in freshwater lake ecosystems. Changes in WD and SA drive changes in nutrients and other primary producers that may have direct or indirect effects on submersed plant growth, but which factor dominates the impact of both on aquatic plants has not been fully studied.

Methods

To investigate the dominant factors that influence aquatic plant growth in plateau lakes, a one-year field study was conducted to study the growth of three dominant submersed macrophyte (i.e., Vallisneria natans, Potamogeton maackianus, and Potamogeton lucens) in Erhai Lake.

Results

The results show that, the biomass of the three dominant plants, P.maackianus, is the highest, followed by P.lucens, and V.natans is the lowest. Meanwhile, periphyton and snails attached to P.maackianus are also the highest. Furthermore, WD had a positive effect on the biomass of two submersed macrophyte species of canopy-type P.maackianus and P.lucens, while it had a negative effect on rosette-type V.natans. Snail directly inhibited periphyton attached on V.natans and thereby increasing the biomass of aquatic plants, but the effect of snails on the biomass of the other two aquatic plants is not through inhibition of periphyton attached to their plants.

Discussion

The dominant factors affecting the biomass of submersed macrophyte in Erhai Lake were determined, as well as the direct and indirect mechanisms of WD and snails on the biomass of dominant submersed macrophyte. Understanding the mechanisms that dominate aquatic plant change will have implications for lake management and restoration.
Remote work arrangement: a blessing in disguise for socially anxious individuals
Authors: Khan Khalid , e-Habiba Umm , Aziz Shahab , Sabeen Zara , Zeeshan Asma , Naz Zareen , Waseem Muhammad
Published: May 2024

This research examines the link between social anxiety disorder (SAD), psychological distance (PD), and burnout using survey data from 463 software development workers who are currently working remotely. According to the results of the study, SAD was associated with higher PD, but, in contrast to what had been shown in earlier studies, this higher PD had no effect on the participants' reported levels of burnout. Both psychological safety and workplace attachment orientation (WAO) were tested for their moderating effects in this study. According to the study's findings, the link between SAD and PD was moderated by WAO but not by psychological safety. The findings of this study underscore the importance of conducting additional research on the challenges faced by people with social anxiety in the workplace and the steps that can be taken by employers to better accommodate them.
Sense of agency at a gaze-contingent display with jittery temporal delay
Authors: Kim Junhui , Yoshida Takako
Published: May 2024

Introduction

Inconsistent jittery temporal delays between action and subsequent feedback, prevalent in network-based human–computer interaction (HCI), have been insufficiently explored, particularly regarding their impact on the sense of agency (SoA). This study investigates the SoA in the context of eye-gaze HCI under jittery delay conditions.

Methods

Participants performed a visual search for Chinese characters using a biresolutional gaze-contingent display, which displayed a high-resolution image in the central vision and a low-resolution in the periphery. We manipulated the delay between eye movements and display updates using a truncated normal distribution (μ to μ + 2 σ) with μ ranging from 0 to 400 ms and σ fixed at 50 ms. Playback of recorded gaze data provided a non-controllable condition.

Results

The study revealed that both reported authorship and controllability scores, as well as the fixation count per second, decreased as μ increased, aligning with trends observed under constant delay conditions. The subjective authorship weakened significantly at a μ of 94 ms. Notably, the comparison between jittery and constant delays indicated the minimum value (μ) of the distribution as a critical parameter influencing both authorship perception and visual search time efficiency.

Discussion

This finding underscores the importance of the shortest delay in modulating SoA. Further examining the relative distribution for fixation duration and saccade amplitude suggests an adaptation in action planning and attention distribution in response to delay. By providing a systematic examination of the statistical attributes of jittery delays that most significantly affect SoA, this research offers valuable implications for the design of efficient, delay-tolerant eye-gaze HCI, expanding our understanding of SoA in technologically mediated interactions. Moreover, our findings highlight the significance of considering both constant and variable delay impacts in HCI usability design, marking a novel contribution to the field.
A bibliometrics review of the journal mindfulness: science mapping the literature from 2012 to 2022
Authors: Hsieh Chuan-Chung , Li Shun
Published: May 2024

This study conducts a bibliometric analysis using the Web of Science database on 1,950 articles published in the journal Mindfulness from 2012 to 2022. By constructing a knowledge graph, the research delineates the evolution, stages of development, and emerging trends in the field of mindfulness. Significant growth in the annual publication volume has been observed since 2012, with the research progression segmented into three distinct phases. The United States has emerged as a pivotal contributor to the field, dominating in terms of publication volume, researcher involvement, and institutional contributions. Through the application of keyword co-occurrence and reference co-citation analysis, five principal clusters were identified, focusing on mindfulness, meditation, depression, stress, and self-compassion, underscoring these as focal research areas. Furthermore, the exploration of mindfulness within the educational sphere in Taiwan is still nascent, signaling a critical need for bolstered research support in diverse thematic domains.
Hyperhomocysteinemia is associated with the risk of venous thromboembolism in patients with mental illness: a case-control study
Authors: Wang Jiaoyan , Zhang Yingchun , Ren Keming , Li Yeping , Ying Kejing
Published: May 2024

Objective

The risk of venous thromboembolism in patients with mental illness has been insufficiently addressed. This study aimed to assess the correlation between hyperhomocysteinemia and venous thromboembolism prevalence among this population.

Methods

Patients with a diagnosis of mental illness and concurrent venous thromboembolism, admitted to Sir Run Run Shaw Hospital at Zhejiang University School of Medicine between January 2014 and December 2021, were included in the venous thromboembolism group. The control group, approximately twice the size, comprised individuals with mental illness but without venous thromboembolism. Basic clinical data were gathered for both cohorts.

Results

In psychiatric patients, elevated D-dimer levels(OR=5.60,95% CI 3.28–10.00), hyperhomocysteinemia (OR=2.37,95% CI 1.10–5.14), and hyperprolactinemia(OR= 2.68,95% CI 1.12–6.42)were significant risk factors for venous thromboembolism. According to further subgroup analyses, hyperhomocysteinemia is a significant risk factor associated with pulmonary embolism, with an OR of 5.08 (95% CI 1.20–21.48). An interaction effect between gender and homocysteine level was found, with a p-interaction of 0.022. A subsequent analysis confirmed the association between hyperhomocysteinemia and venous thromboembolism in female psychiatric patients, with an OR of 3.34 (95% CI 1.68–6.65), indicating that hyperhomocysteinemia is a significant risk factor for venous thromboembolism in women.

Conclusion

Patients with psychiatric disorders were found to have an elevated risk of venous thromboembolism, which was associated with increased levels of D-dimer, hyperprolactinemia, and hyperhomocysteinemia. A strong correlation between hyperhomocysteinemia and pulmonary embolism was identified in patients with mental illnesses. Furthermore, the study revealed that female psychiatric patients with hyperhomocysteinemia constituted a high-risk group for venous thromboembolism. This finding holds significant clinical implications, suggesting that early preventative measures could be implemented for this high-risk population to reduce the incidence of thromboembolic events during hospitalization for psychiatric patients.
Mediating role of loneliness and emotional disturbance in the association between childhood trauma and occupational burnout among nurses: a cross-sectional study
Authors: Hu Jing , Zhai Mengxi , Fu Donghui , Duan Zhizhou , Chen Xiangfan
Published: May 2024

Background

The occupational burnout status of nurses in China warrants attention. Childhood trauma, loneliness, and emotional disturbance are significant predictors of this burnout, yet few studies have delved into the underlying mechanisms. This study seeks to explore the mediating pathway from childhood trauma to loneliness, emotional disturbance, and ultimately occupational burnout among nurses through a cross-sectional analysis.

Method

Data for the study were collected from Yunnan province, China, from 11 July to 26 July 2022. Key variables were measured using standardized scales: the Childhood Trauma Questionnaire Short Form for childhood trauma, the three-item loneliness scale for loneliness, the Patient Health Questionnaire and the Generalized Anxiety Disorder questionnaire for emotional disturbance, and the Maslach Burnout Inventory-Human Service Survey for occupational burnout. Mediation modeling analysis was employed for data analysis to test the effect of loneliness and emotional disturbance on the association between childhood trauma and occupational burnout. Data analysis was conducted using AMOS and SPSS software.

Results

Loneliness and emotional disturbance fully mediated the association between childhood trauma and emotional exhaustion [indirect effect (95% CI) = 0.228 (0.196, 0.270)]. Loneliness and emotional disturbance partially mediated the association between childhood trauma [indirect effect (95% CI) = −0.020 (−0.039, 0.002)] and personal accomplishment or depersonalization [indirect effect (95% CI) = 0.221 (0.186, 0.255)].

Conclusion

Childhood trauma could affect occupational burnout through loneliness and emotional disturbance among nurses. Preventive strategies could include protective interventions like treatment of loneliness and emotional disturbance, especially in nurses who experienced childhood trauma.
Body image dissatisfaction is associated with perceived body weight among secondary school adolescents in Harar Town, eastern Ethiopia
Authors: Tekola Abainash , Regassa Lemma Demissie , Mandefro Miheret , Shawel Samrawit , Kassa Obsan , Shasho Feyisa , Demis Teshome , Masrie Awoke , Tamire Aklilu , Roba Kedir Teji
Published: May 2024

Purpose

Body image dissatisfaction has emerged as an important determinant of dietary and physical activity, which in turn determine adolescents’ nutritional status. Hence, it is important to understand predictors of body image dissatisfaction. Therefore, this study aimed to assess body image dissatisfaction and its associated factors among secondary school adolescents in the study area.

Methods

Data collected for other purposes were used to assess body image dissatisfaction among adolescents in Harar town. Body image dissatisfaction was assessed using the Body Part Satisfaction Scale. Data processing and analysis were performed using STATA version 14, and binary logistic regression was used to identify factors associated with body image dissatisfaction. Factors associated with body image dissatisfaction were determined by estimating AOR along with 95% CI and the statistical significance was declared at a p-value less than or equal to 0.05.

Result

The prevalence of body image dissatisfaction was 22.06% [95% CI (19.63, 24.70)]. This study also revealed that males were more dissatisfied with their upper torso and face, and females were more dissatisfied with their middle torso, lower torso, height, and weight than males. In this study, body image dissatisfaction was associated with perception of being fat [AOR = 1.89, 95% CI (1.23, 2.91)], anxiety [AOR = 1.59, 95% CI (1.02, 2.48)], and cigarette smoking [AOR = 1.63, 95% CI (1.03, 2.58)].

Conclusion

Almost one in five secondary school adolescents in Harar had body image dissatisfaction, which was significantly associated with perceptions of being fat, anxiety, and smoking. In this study, a significant number of the adolescents experienced body image dissatisfaction. Hence, all concerned bodies have to take action to reduce the burden.
Comparison of the burden of digestive diseases between China and the United States from 1990 to 2019
Authors: Peng Jieyu , Xu Huan , Huang Shu , Shi Xiaomin , Wang Ping , Chen Qi , Zhang Wei , Shi Lei , Peng Yan , Yuan Fangfang , Tang Xiaowei
Published: May 2024

Introduction

China has experienced unprecedented transformations unseen in a century and is gradually progressing toward an emerging superpower. The epidemiological trends of digestive diseases in the United States (the US) have significant prescient effects on China.

Methods

We extracted data on 18 digestive diseases from the Global Burden of Diseases 2019 Data Resource. Linear regression analysis conducted by the JoinPoint software assessed the average annual percentage change of the burden. We performed subgroup analyses based on sex and age group.

Results

In 2019, there were 836.01 and 180.91 million new cases of digestive diseases in China and the US, causing 1558.01 and 339.54 thousand deaths. The age-standardized incidence rates of digestive diseases in China and the US were 58417.87/100,000 and 55018.65/100,000 respectively, resulting in age-standardized mortality rates of 81.52/100,000 and 60.88/100,000. The rates in China annually decreased by 2.149% for mortality and 2.611% for disability-adjusted life of year (DALY). The mortality and DALY rates of the US, respectively, had average annual percentage changes of −0.219 and −0.251. Enteric infections and cirrhosis and other chronic liver diseases accounted for the highest incidence and prevalence in both counties, respectively. The burden of multiple digestive diseases exhibited notable sex disparities. The middle-old persons had higher age-standardized prevalence rates.

Conclusion

China bore a greater burden of digestive diseases, and the evolving patterns were more noticeable. Targeted interventions and urgent measures should be taken in both countries to address the specific burden of digestive diseases based on their different epidemic degree.
Association between history of cannabis use and outcomes after total hip or knee arthroplasty: a systematic review and meta-analysis
Authors: Yang Guangyao , Li Feng , Wang Qiuyuan , Liu Youwen , Guo Jiayi , Yue Chen
Published: May 2024

Background

Cannabis use may be increasing as countries legalize it and it becomes socially acceptable. A history of cannabis use may increase risk of complications after various kinds of surgery and compromise functional recovery. Here we systematically reviewed and meta-analyzed available evidence on how history of cannabis use affects recovery after hip or knee arthroplasty (THA/TKA).

Methods

The PubMed, EMBASE, and Web of Science databases were comprehensively searched and studies were selected and analyzed in accordance with the PRISMA guidelines. The methodological quality of included studies was assessed based on the Newcastle-Ottawa Scale, while quality of evidence was evaluated according to the “Grading of recommendations assessment, development, and evaluation” system. Data on various outcomes were pooled when appropriate and meta-analyzed.

Results

The systematic review included 16 cohort studies involving 5.91 million patients. Meta-analysis linked history of cannabis use to higher risk of the following outcomes: revision (RR 1.68, 95% CI 1.31–2.16), mechanical loosening (RR 1.77, 95% CI 1.52–2.07), periprosthetic fracture (RR 1.85, 95% CI 1.38–2.48), dislocation (RR 2.10, 95% CI 1.18–3.73), cardiovascular events (RR 2.49, 95% CI 1.22–5.08), cerebrovascular events (RR 3.15, 95% CI 2.54–3.91), pneumonia (RR 3.97, 95% CI 3.49–4.51), respiratory failure (RR 4.10, 95% CI 3.38–4.97), urinary tract infection (RR 2.46, 95% CI 1.84–3.28), acute kidney injury (RR 3.25, 95% CI 2.94–3.60), venous thromboembolism (RR 1.48, 95% CI 1.34–1.63), and deep vein thrombosis (RR 1.42, 95% CI 1.19–1.70). In addition, cannabis use was associated with significantly greater risk of postoperative transfusion (RR 2.23, 95% CI 1.83–2.71) as well as higher hospitalization costs.

Conclusion

History of cannabis use significantly increases the risk of numerous complications and transfusion after THA or TKA, leading to greater healthcare costs. Clinicians should consider these factors when treating cannabis users, and pre-surgical protocols should give special consideration to patients with history of cannbis use.
Suicidal ideation and their relationship with job satisfaction and job strain among Jordanian hospitals’ healthcare professionals: a cross-sectional study
Authors: Alnajdawi Ann Mousa , Alsawalqa Rula Odeh , Alrawashdeh Maissa N.
Published: May 2024

Suicidal ideation is a major health problem that occurs in response to complex interactions among psychological, sociocultural, and environmental factors. The phenomenon of suicidal ideation among healthcare professionals is still shrouded in mystery in Jordanian society, and there is still a scarcity of studies on its relationship with job strain and job satisfaction has been examined in the Arab world. Therefore, to fill this gap, this study aimed to reveal the prevalence of suicidal ideation among Jordanian hospitals health care professionals, and its relationship to job satisfaction and job strain. Additionally, how some sociodemographic factors were correlated with suicidal ideation levels, including age, sex, monthly income, occupation, years of experience, and sector type. Data were collected through a survey including sociodemographic characteristics, Suicidal ideation Scale (SIS), Job Satisfaction Survey (JSS), and Demand Control Support Questionnaire (DCSQ). The survey was distributed among 910 physicians and nurses of both sexes in public and private Jordanian hospitals. The survey was conducted using an anonymous online platform via Google Forms between October 2022 and December 2023. In light of the strain theory of suicide (STS), our results showed that physicians and nurses reported low levels of suicidal ideation and job satisfaction, with high levels of job strain. Suicidal ideation was positively correlated with job strain and negatively correlated with job satisfaction. Job satisfaction is negatively correlated with job strain. Job satisfaction was a significant mediator between job strain and suicidal ideation. Greater attention should be paid to the work environment in healthcare, particularly to enhance social support, increase job satisfaction levels, reduce job strain, and provide extensive training on effective prevention strategies for suicidal ideation and behaviour in the workplace. Additionally, policies and practices related to the health sector should be modified to create stable, healthy, and safe relationships and work environments.
A pharmacist's role in increasing access to menstrual products: an education and advocacy approach
Authors: Potter Kristal , Beal-Stahl Jessica
Published: May 2024

Individuals who menstruate grapple with diverse challenges in menstrual and reproductive health. This includes financial burdens, societal stigmas, and negative mental and physical health implications. Period poverty, marked by insufficient access to menstrual products, education, and sanitation, remains a prevalent and poorly addressed issue. Alarming statistics highlight the extent of this problem and shed light on the staggering number of individuals lacking access to essential menstrual products. The discourse extends to the safety and accessibility of a diverse array of menstrual products. A comprehensive comparison of the cost of available period products was conducted using data obtained from various retail websites. The often-overlooked potential indirect expenses and profound impacts on quality of life were also discussed. Amidst other public health initiatives, pharmacists have emerged as pivotal advocates and educators. Pharmacists are poised to drive initiatives that increase access to menstrual products through public health education and advocacy. By providing education on different menstrual product options, pharmacists can empower individuals to make informed decisions based on their needs. This perspective illuminates the complex impacts of menstruation on individuals and proposes that pharmacists can play a role in overcoming barriers to access. The proposed strategies, rooted in education, research, and advocacy, pave the way for enhancing access, reducing stigma, and elevating the quality of life for those navigating the intricate complexities of menstruation.
Integrated techno-economic and life cycle assessment of hydroformylation in microemulsion systems
Authors: Wunderlich Johannes , Kretzschmar Philipp , Schomäcker Reinhard
Published: May 2024

This paper presents the first integrated techno-economic and life cycle assessment of microemulsion systems being applied for rhodium-catalyzed hydroformylation of long-chain alkenes at industrial scale. The case study describes a projected 150 kt/a production of tridecanal (US gulf coast, 2019). The industrial success of the hydroformylation of short-chain alkenes lies in the continuous recycling of the rhodium-containing water phase. Microemulsion systems can be applied to transfer this concept to long-chain alkenes by overcoming the miscibility gap between the aqueous catalyst phase and the unipolar alkene phase and, moreover, by generating a temperature-induced multi-phase system enabling the immobilization of the catalyst and its continuous recycling, as demonstrated in miniplant operations with dodecene and rhodium/SulfoXantPhos. Customizable simulation models have been developed for scale-up and assessment of the miniplant data. Surprisingly, a profitability-driven sensitivity study indicates a base case optimum at low residence time with low alkene conversion leading to large throughput streams and high raw material purge rates. The comparison to the industrial cobalt-based benchmark system shows an economic advantage regarding net present value (Rh: 68 M$; Co: 62 M$), while about half of the environmental indicators are in favor or equivalent. In a best-case scenario considering zero leaching of expensive rhodium the net present value increases by almost 40% accompanied by a shift to overall lower environmental impacts than the benchmark. In conclusion, the investigated miniplant data suggest microemulsion systems to be competitive when applied in continuous processes at a large scale.
A critical narrative questioning the assessment of physical literacy: foster authentic human flourishing across the life course
Authors: Huang Yan
Published: May 2024

The study provides a summary, reflection, and clarification on the existing literature amid the recent rise in physical literacy assessment through a critical narrative that will contribute to future developments. In this review, the author addressed the significance of acknowledging the ultimate goal of assessing physical literacy throughout the life course is to foster authentic human flourishing. The study questioned the assessment practice in detail by discussing whether it is to translate and validate or to establish locally and to quantify or to specify qualitatively. The current tendency of a comprehensive dimension but not an inclusive journey was found. Subject to limitation, the merits of this study still stand and, moreover, further point to valuable areas for further inquiry that may refine and foster physical literacy and authentic human flourishing across the life course. And based on the arguments, future direction and recommendations when conducting assessment were discussed.
The potential for minimally invasive intracerebral hemorrhage evacuation in routine healthcare: applicability of the ENRICH trial criteria to an unselected cohort
Authors: Apostolaki-Hansson Trine , Hillal Amir , Göransson Nathanael , Hansen Björn M. , Norrving Bo , Ramgren Birgitta , Wassélius Johan , Ullberg Teresa
Published: May 2024

Objective

Following the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden.

Methods

All patients with spontaneous ICH in the Swedish Stroke Register (RS) during 2017–2020 in Skane county (1.37 million) were assessed. Baseline imaging was used for radiological characterization. Clinical data were obtained from RS. MIS eligibility in the total ICH population meeting ENRICH criteria were estimated and extrapolated to the Swedish population (10.5 million).

Results

Of 1,314 ICH patients, 5.9% met the ENRICH criteria for MIS (ICH volume 30–80 ml). Considering the ENRICH trial results indicating the effectiveness of MIS was mainly attributable to intervention for lobar hemorrhages, we determined that 2.8% of our ICH cohort in Sweden would be eligible for MIS. The estimated rate of neurosurgery for ICH could increase from the current 1.46–1.90 patients/100,000 population/year (in absolute numbers from 154 to 200 interventions out of 2,400 ICHs in Sweden annually).

Conclusions

We show that 2.8% of the Skane ICH population would be eligible for MIS if ENRICH criteria are employed for patients with lobar ICH, corresponding to a 29% increase of current surgical rates for ICH in Sweden. As MIS for ICH is not yet standard practice in Sweden, consideration for its implementation within the neurosurgical organization becomes essential to accommodate the anticipated increase in patient demand.
Establishment of a novel weight reduction model after laparoscopic sleeve gastrectomy based on abdominal fat area
Authors: Feng Tianyi , Hu Sanyuan , Song Changrong , Zhong Mingwei
Published: May 2024

In light of ongoing research elucidating the intricacies of obesity and metabolic syndrome, the role of abdominal fat (especially visceral fat) has been particularly prominent. Studies have revealed that visceral adipose tissue can accelerate the development of metabolic syndrome by releasing various bioactive compounds and hormones, such as lipocalin, leptin and interleukin. A retrospective analysis was performed on the clinical data of 167 patients with obesity. Among them, 105 patients who satisfied predefined inclusion and exclusion criteria were included. The parameters evaluated included total abdominal fat area (TAFA), laboratory indicators and anthropometric measurements. Weight reduction was quantified through percent total weight loss (%TWL) and percent excess weight loss (%EWL) postoperatively. Binary logistic regression analysis and receiver operating characteristic (ROC) curve analysis were employed to identify predictors of weight loss. Binary logistic regression analysis emphasized that total abdominal fat area was an independent predictor of %EWL ≥75% (p < 0.001). Total abdominal fat area (p = 0.033) and BMI (p = 0.003) were independent predictors of %TWL ≥30%. In our cohort, %TWL ≥30% at 1 year after surgery was closely related to the abdominal fat area and BMI. Based on these results, we formulated a novel model based on these factors, exhibiting superior predictive value for excellent weight loss.
Case report: Chronic disseminated intravascular coagulopathy with concurrent paraneoplastic secondary hyperfibrinolysis in a dog with metastatic nasal adenocarcinoma
Authors: Granger Kyle L. , Paulos Trish , Boss Mary-Keara , Guieu Liz , Shropshire Sarah
Published: May 2024

In human medicine, hemostatic disorders such as thrombocytopenia, hyperfibrinolysis, and disseminated intravascular coagulopathy (DIC) have been associated with many cancers. Acute hemorrhage secondary to hyperfibrinolysis has been predominantly reported with prostatic adenocarcinoma in human patients. To the author’s knowledge, severe bleeding due to paraneoplastic hyperfibrinolysis has not yet been reported in veterinary medicine. The case involves an 8-year-old neutered male Border Collie who was evaluated for progressive and recurrent epistaxis, having a history of 1 year of treatment for metastatic nasal adenocarcinoma. A progressive and severe coagulopathy thought to be related to the known cancer was diagnosed. Advanced coagulation testing was consistent with a chronic DIC and secondary hyperfibrinolysis. Throughout 1 week of hospitalization, the dog was treated with multiple blood products, vitamin K1, and anti-fibrinolytic medications. While the dog was initially discharged home, the dog re-presented the following day and was humanely euthanized due to a perceived poor quality of life. Post-mortem analysis revealed a histopathologic diagnosis of disseminated adenocarcinoma. In dogs with disseminated nasal adenocarcinoma that are experiencing severe bleeding, paraneoplastic secondary hyperfibrinolysis should be considered as a differential. Knowing this association could help guide treatment recommendations for optimal patient management.
Impact of Ar/CF4 Mixed Gas Flow Rate on Silicon Etching Using Surface Discharge Plasma
Authors: Hamada Toshiyuki , Nishida Kazuki , Yoshida Masafumi
Published: May 2024

This study examines the effects of varying argon (Ar) and carbon tetrafluoride (CF4) gas flow rates on the etching of monocrystalline silicon substrates using surface discharge plasma. While previous research has primarily focused on the fundamental characteristics and applications of surface discharge plasma in silicon etching, the influence of the gas flow rate on etching efficacy remains insufficiently explored. The aim of this study is to elucidate the relationship between mixed gas flow rates and the rate and quality of silicon etching, both of which are critical for optimizing manufacturing processes in the semiconductor industry. Utilizing a setup equipped with a USB4000 spectrometer for emission spectroscopy, we varied the Ar/CF4 flow rates from 0 to 6000 sccm while maintaining a fixed discharge-sustaining voltage of 9.4 kV. We observed and analyzed the discharge power, plasma emission intensities, and resulting etch profiles of the silicon substrates. Particularly, we analyzed the emission spectra for peaks corresponding to active species such as F, F2, and CFn, indicative of the plasma’s etching capabilities. The findings revealed that higher flow rates significantly enhanced the generation of key active species, leading to increased etching rates in both depth and width directions of the silicon substrates. Importantly, an increase in flow rate also facilitated the diffusion of these species across a broader area, thereby advancing the etching process and inhibiting the deposition of etching byproducts. These results underscore the importance of optimizing gas flow rates to enhance etching efficiency and quality. In conclusion, this study confirms that adjusting the flow rates of Ar and CF4 in surface discharge plasma etching can significantly influence the effectiveness of the silicon etching process. This outcome will contribute to the realization and development of semiconductor etching technology, such as solar cell manufacturing, as well as the further advancement of atmospheric pressure non-equilibrium plasma surface treatment technology.
Flowable Electrodes from Colloidal Suspensions of Thin Multiwall Carbon Nanotubes
Authors: Hamouma Massinissa , Neri Wilfrid , Bril Xavier , Yuan Jinkai , Colin Annie , Brémond Nicolas , Poulin Philippe
Published: May 2024

Flowable electrodes, a versatile alternative to traditional solid electrodes for electrochemical applications, exhibit challenges of high viscosity and carbon content, limiting flow and device performances. This study introduces colloidal suspensions of thin multiwall carbon nanotubes (MWCNTs) with diameters of 10–15 nm as electrode materials. These thin nanotubes, stabilized in water with a surfactant, form percolated networks, exhibiting high conductivity (50 ms/cm) and stability at a low carbon content (below 2 wt%). Colloidal clustering is enhanced by weak depletion attractive interactions. The resulting suspensions display yield stress and a shear thinning behavior with a low consistency index. They can easily flow at a nearly constant shear over a broad range of shear rates. They remain electrically conductive under shear, making them a promising option for flow electrochemical applications. This work suggests that the use of depletion-induced MWVNT aggregates addresses crucial issues in flow electrochemical applications, such as membrane fragility, operating energy, and pressure. These conductive colloidal suspensions thereby offer potential advancements in device performance and lifespan.
Analysis of Deployable Cylindrical Space Bar Structures of Reciprocal Linkages with Frustoconical Ends
Authors: Pérez-Valcárcel Juan , Muñoz-Vidal Manuel , López-César Isaac R. , Freire-Tellado Manuel J. , Suárez-Riestra Félix
Published: May 2024

In this article, deployable cylindrical vaults of reciprocal linkages with frustoconical ends are analysed. Deployable cylindrical vaults with quadrangular scissors modules have low stiffness in the longitudinal direction, which requires the use of stiffening bars after deployment. The truncated cone-shaped ends improve their stiffness but do not prevent bracing. However, if reciprocal knots are used, the mesh performance improves considerably. This article studies the design conditions of these vaults and their resistance to gravity, wind suction and wind loads in the transverse and longitudinal directions. We also study the different resistance behaviour of the mesh, depending on whether the roof is supported on the upper or lower joints. In all cases, model tests are carried out to check the validity of the proposed solutions. Both theoretical calculations and experimental tests demonstrate the viability and effectiveness of this type of structure.
A Comprehensive Review on Circulating cfRNA in Plasma: Implications for Disease Diagnosis and Beyond
Authors: Zhong Pengqiang , Bai Lu , Hong Mengzhi , Ouyang Juan , Wang Ruizhi , Zhang Xiaoli , Chen Peisong
Published: May 2024

Circulating cfRNA in plasma has emerged as a fascinating area of research with potential applications in disease diagnosis, monitoring, and personalized medicine. Circulating RNA sequencing technology allows for the non-invasive collection of important information about the expression of target genes, eliminating the need for biopsies. This comprehensive review aims to provide a detailed overview of the current knowledge and advancements in the study of plasma cfRNA, focusing on its diverse landscape and biological functions, detection methods, its diagnostic and prognostic potential in various diseases, challenges, and future perspectives.
Light Intensity of Phosphorescent-Netting Pots and Determining Their Visibility to Snow Crab (Chionoecetes opilio) Using Visual Modeling Techniques
Authors: Frank Colin , Bayse Shannon , Steiner Rioghnach , Bitton Pierre-Paul
Published: May 2024

This study explores the visibility of phosphorescent-netting pots to snow crab (Chionoecetes opilio) using visual modeling techniques. Light emitted from such pots increases catch per unit effort, yet little is understood about the factors driving these higher catch rates. In this study, we measure pot light emission and snow crab visual acuity. Combining these data with estimates obtained in the literature for other biotic and abiotic factors, we model snow crab vision in relation to the pots. Utilizing these factors and environmental conditions, we derive a contrast ratio between the pot light and the ambient light. Findings reveal that the visibility of pot lights at 200-m depth depends primarily on solar angle (time of day) and time elapsed post-deployment. Additional factors influencing the vision of the pots include water column quality and benthic boundary layer turbidity. This study is the first to model the visual ecology of snow crab and the first to estimate snow crab visual acuity. These insights into snow crab visual ecology can potentially enhance fishing techniques, promote catch efficiency and sustainability, and help provide a path forward for visual ecology research in the fisheries science field.