bluuebunny/crossref_metadata_2025 huggingface dataset:
Full-Reference Image Quality Assessment Based on an Optimal Linear Combination of Quality Measures Selected by Simulated Annealing
Authors: Varga Domonkos
Published: August 2022

Digital images can be distorted or contaminated by noise in various steps of image acquisition, transmission, and storage. Thus, the research of such algorithms, which can evaluate the perceptual quality of digital images consistent with human quality judgement, is a hot topic in the literature. In this study, an image quality assessment (IQA) method is introduced that predicts the perceptual quality of a digital image by optimally combining several IQA metrics. To be more specific, an optimization problem is defined first using the weighted sum of a few IQA metrics. Subsequently, the optimal values of the weights are determined by minimizing the root mean square error between the predicted and ground-truth scores using the simulated annealing algorithm. The resulted optimization-based IQA metrics were assessed and compared to other state-of-the-art methods on four large, widely applied benchmark IQA databases. The numerical results empirically corroborate that the proposed approach is able to surpass other competing IQA methods.
Modeling and Dynamic Analysis of a Triple-Tagline Anti-Swing System for Marine Cranes in an Offshore Environment
Authors: Sun Maokai , Wang Shenghai , Han Guangdong , An Lin , Chen Haiquan , Sun Yuqing
Published: August 2022

Payload lifting is inefficient and high-risk under rough sea conditions. Thus, it is not easy to achieve precise assembly, and the swing payload is liable to collide with other structures on deck and cause damage. In this paper, to explore the complex dynamic characteristics of a triple-tagline anti-swing system (TTAS) for marine cranes in an offshore environment, an irregular wave model was first integrated into a dynamic system model of TTAS, and the TTAS for offshore payload lifting was simplified as a constrained-pendulum system with moving base excitations. Further, the dynamic system model was established by applying the methods in robotics. Meanwhile, the dynamic characteristics were simulated and analyzed using Matlab/Simulink. The simulation results show that the in-plane angle and out-of-plane angle of the payload can be effectively suppressed, and the range of the two-dimensional trajectory of the payload is greatly reduced. The research results provide a theoretical basis for optimizing the mechanical structures of TTAS or similar equipment.
Modern Techniques for Flood Susceptibility Estimation across the Deltaic Region (Danube Delta) from the Black Sea’s Romanian Sector
Authors: Crăciun Anca , Costache Romulus , Bărbulescu Alina , Pal Subodh Chandra , Costache Iulia , Dumitriu Cristian Ștefan
Published: August 2022

Floods have become more and more severe and frequent with global climate change. The present study focuses on the Black Sea’s immediate riparian area over which the Danube Delta extends. Due to the accelerated increase in the severity of floods, the vulnerability of the deltaic areas is augmenting. Therefore, it is very important to adopt measures to mitigate the negative effects of these phenomena. The basis of the measures to limit the negative effects is the activity of identifying areas prone to flooding. Thus, this research paper presents a methodology for estimating flood susceptibility using the Analytical Hierarchy Process (AHP) and Fuzzy-Analytical Hierarchy Process (FAHP) models. To determine the susceptibility to these natural risk phenomena, the following eight flood predictors were taken into account: slope, elevation, altitude above channel, land use, hydrological soil group, lithology distance from the river, and distance from water bodies. Furthermore, the weights that each flood predictor has in terms of determining flood susceptibility were determined through the previously mentioned models. The results revealed that the slope is the most important predictor, followed by elevation, distance from the river, and land use. These weights were used in the GIS environment to evaluate the susceptibility to floods from a spatial point of view. The areas with a high/very high value for these phenomena occupy over 70% of the surface of the Danube Delta.
A Realistic and Integrated Model for Evaluating Offshore Oil Development
Authors: Qiu Rui , Li Zhuochao , Zhang Qin , Yao Xin , Xie Shuyi , Liao Qi , Wang Bohong
Published: August 2022

With the rising consumption of oil resources, major oil companies around the world have increasingly engaged in offshore oil exploration and development, and offshore oil resources have accounted for an increasing proportion. Offshore oil engineering projects are capital intensive, and the development of offshore oil fields faces a tough battle, especially in a period of low oil prices. Thus, a comprehensive evaluation model is highly needed to help assess economic benefits and provide meaningful and valuable information for operators and investors to make sensible decisions. This study firstly proposed a realistic and integrated evaluation model for offshore oil development based on actual historical project data. This evaluation model incorporated modules from the underwater system to the platform system and processes from oil reservoir extraction to oil, gas and water treatment. The uncertain parameters in the evaluation process are dealt with by sensitivity analysis and Monte Carlo simulation. The proposed model is applied to a typical offshore oil development project in Bohai Bay, China. The results reveal that the recovery factor and oil price have the greatest impact on the economic benefits. In the case of deterministic analysis, the breakeven oil price of the project is 40.59 USD/bbl. After considering the uncertainty of project parameters, the higher the oil price, the greater the probability of NPV > 0. When the oil price is higher than 70 USD/bbl, even with uncertain project parameters, the probability of NPV > 0 can still be as high as 97.39%.
Importance of Pre-Storm Morphological Factors in Determination of Coastal Highway Vulnerability
Authors: Pesantez Jorge E. , Behr Adam , Sciaudone Elizabeth
Published: August 2022

This work considers a database of pre-storm morphological factors and documented impacts along a coastal roadway. Impacts from seven storms, including sand overwash and pavement damage, were documented via aerial photography. Pre-storm topography was examined to parameterize the pre-storm morphological factors likely to control whether stormwater levels and waves impact the road. Two machine learning techniques, K-nearest neighbors (KNN) and ensemble of decision trees (EDT), were employed to identify the most critical pre-storm morphological factors in determining the road vulnerability, expressed as a binary variable to impact storms. Pre-processing analysis was conducted with a correlation analysis of the predictors’ data set and feature selection subroutine for the KNN classifier. The EDTs were built directly from the data set, and feature importance estimates were reported for all storm events. Both classifiers report the distances from roadway edge-of-pavement to the dune toe and ocean as the most important predictors of most storms. For storms approaching from the bayside, the width of the barrier island was the second most important factor. Other factors of importance included elevation of the dune toe, distance from the edge of pavement to the ocean shoreline, shoreline orientation (relative to predominant wave angle), and beach slope. Compared to previously reported optimization techniques, both machine learning methods improved using pre-storm morphological data to classify highway vulnerability based on storm impacts.
Investigations on the Effectiveness of Protection Methods for a Submarine Pipeline Exposed to the Impact of a Falling Anchor
Authors: Zhang Ciheng , Zang Zhipeng , Zhao Ming , Chen Yanfei , Zhang Jinfeng
Published: August 2022

The occurrence of a buried submarine pipeline crossing a channel becoming damaged by the impact of a falling anchor is becoming more common. It is important to analyze the dynamic response of pipelines exposed to such impact and develop effective protection methods to ensure the safe operation of the pipelines exposed to the impact of falling anchors. In this study, different protection methods, including pure rock, concrete mattress + rock, concrete mattress + rock + rubber pad, and compound flexible pad + rock, are physically tested. The strains at the impacting point and along the pipeline were measured with the fiber Bragg grating (FBG) sensors. The effectiveness of the protection methods is analyzed based on the maximum strain and its affected length on the pipeline. Then, a theoretical model is established to analyze the deformation and strain of a pipeline. Through curve-fitting the experimental results, the bearing capacity coefficients for different protection methods are determined. The protection method of compound flexible pad + rock has the best performance to protect the pipeline from the impact of a falling anchor.
Exploring Biocontrol of Unwanted Fungi by Autochthonous Debaryomyces hansenii Strains Isolated from Dry Meat Products
Authors: Chacón-Navarrete Helena , Ruiz-Pérez Francisco , Ruiz-Castilla Francisco J. , Ramos José
Published: August 2022

The exploration of alternatives to the use of chemical preservatives in food is a topic that has attracted great attention. The implementation of regulations associated with the reduction of these elements directly affects the production of cured meat products, with the premise of looking for more “natural” alternatives. From a previously identified collection of 24 strains of Debaryomyces hansenii, isolated from dry meat products of the “Valle de los Pedroches” (Córdoba), a screening was carried out to determine which strains had inhibitory potential against a battery of fungi belonging to the genera Aspergillus, Penicillium, and Candida. After a series of general trials, four strains showing the greatest potential were selected by a streak inhibition assay performed at several concentrations of NaCl. The inhibitory activity of the selected D. hansenii strains was later evaluated by measuring their fungal antagonistic diffusible and volatile compound production following radial inhibition and mouth-to-mouth approaches, respectively. Growth aspects, sporulation, and morphology changes were also considered during these assays. The results support ideas already raised in previous studies, such as the presence of D. hanseniii could imply a reduction of pathogenic fungi in food. Autochthonous yeast strains inhibited not only the mycelial growth, but also sporulation, which strengthens the biocontrol activity of this yeast. Our results show that, under certain conditions, all tested D. hansenii strains were able to alter the growth/development of fungi, being especially evident in the cases of Penicillium expansum and Aspergillus niger. Finally, our research can facilitate the future comparison of results in this area, since we contributed to standardize the methodology described to date, we quantified the number of yeast cells and spores used during the experiments, we homogenized growth conditions for both, yeasts, and molds, and applied an image analyzer software to quantify the growth of the studied microorganisms in solid media.
Epigenetic Regulation of Antifungal Drug Resistance
Authors: Patra Sandip , Raney Mayur , Pareek Aditi , Kaur Rupinder
Published: August 2022

In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance. Emerging resistance to the limited therapeutic options for the treatment of invasive fungal infections is a growing concern. Human fungal pathogens develop drug resistance via multiple mechanisms, with recent studies highlighting the role of epigenetic changes involving the acetylation and methylation of histones, remodeling of chromatin and heterochromatin-based gene silencing, in the acquisition of antifungal resistance. A comprehensive understanding of how pathogens acquire drug resistance will aid the development of new antifungal therapies as well as increase the efficacy of current antifungals by blocking common drug-resistance mechanisms. In this article, we describe the epigenetic mechanisms that affect resistance towards widely used systemic antifungal drugs: azoles, echinocandins and polyenes. Additionally, we review the literature on the possible links between DNA mismatch repair, gene silencing and drug-resistance mechanisms.
Characterization of the Fungal Community in Fritillariae Cirrhosae Bulbus through DNA Metabarcoding
Authors: Yu Jingsheng , Zhang Wenjuan , Dao Yujie , Yang Meihua , Pang Xiaohui
Published: August 2022

Fritillariae Cirrhosae Bulbus (FCB) is a well-known and precious traditional Chinese medicine with a medicinal history spanning thousands of years. In recent years, it has been reported that fungal and mycotoxin contamination influenced the safety and quality of FCB. It is essential to systematically study the fungal community for the early warning of fungal and mycotoxin contamination in this herb. A total of 15 FCB samples were collected from five provinces in China, and the fungal communities in the FCB samples were analyzed via amplifying the internal transcribed spacer 2 region through the Illumina Miseq PE300 platform. Furthermore, we compared the differences in fungal community in five groups based on collection areas. Results showed that Ascomycota (41.58–99.66%) and Mucoromycota (0–57.42%) were dominant at the phylum level. Eurotiomycetes (8.49–63.93%), Eurotiales (8.49–63.53%), and Aspergillaceae (8.49–63.51%) were the most abundant at the class, order, and family levels. Aspergillus (8.49–63.41%), Rhizopus (0–57.42%), Fusarium (0–22.81%), Cladosporium (0.16–9.14%), and Alternaria (0.06–17.95%) were the main genera in FCB samples. A total of 34 fungal taxa were identified at the species level, including five potentially toxigenic fungi namely Penicillium brevicompactum, P. citrinum, P. oxalicum, Trichothecium roseum, and Aspergillus restrictus. The differences in fungal community between the five groups were observed. Our findings provide references for the safe utilization and quality improvement of FCB.
Polyphasic Systematics of the Fungicolous Genus Cladobotryum Based on Morphological, Molecular and Metabolomics Data
Authors: Milic Nikola , Christinaki Anastasia C. , Benaki Dimitra , Stavrou Aimilia A. , Tsafantakis Nikolaos , Fokialakis Nikolas , Kouvelis Vassili N. , Gonou-Zagou Zacharoula
Published: August 2022

(1) Background: Species of the anamorphic genus Cladobotryum, are known for their fungicolous lifestyle, making them important mycopathogens in fungiculture. Many morphological, ecological, and molecular phylogenetic studies of the genus have been done to date, but taxonomic uncertainties and challenges still remain. Fungal secondary metabolites, being vastly diverse, are utilised as an extra tool in fungal systematics. Despite being studied for their potentially bioactive compounds, Cladobotryum species are insufficiently investigated regarding metabolomics. (2) Methods: The aim of this study is the identification of Greek strains of Cladobotryum by integrating morphological data, ITS-based phylogeny, and 1H NMR-based metabolomics into a polyphasic approach. (3) Results: Twenty-three strains, isolated from sporophores of macromycetes inhabiting diverse Greek ecosystems, were morphologically identified as Cladobotryum apiculatum, C. fungicola, C. mycophilum, C. varium, C. verticillatum, and Hypomyces rosellus (anamorph C. dendroides), whereas seven strains, which produced red-pigmented metabolites, presented an ambiguous taxonomic position at the species level. Molecular phylogenetics and metabolomics corroborated the morphological findings. (4) Conclusions: Thorough morphological study, ITS region-based phylogeny, and NMR-based metabolomics contribute complementarily to resolving the genus Cladobotryum systematics.
The Adjuvant Therapy of Intravenous Laser Irradiation of Blood (ILIB) on Pain and Sleep Disturbance of Musculoskeletal Disorders
Authors: Fu (Jimmy) Chun-Ming , Wang Nai-Kuang , Cheng Yuan-Yang , Chang Shin-Tsu
Published: August 2022

(1) Background: Musculoskeletal pain is both intractable and irritating. Intravenous Laser Irradiation of Blood (ILIB) therapy has been used as pain control treatment for this condition. However, there remains a lack of clear evidence regarding ILIB on pain control. This study aimed to reveal the result of changes in patient pain intensity after receiving ILIB therapy. (2) Methods: We conducted a retrospective analysis of pain scores and sleep quality from 76 patients diagnosed with musculoskeletal disease who received three courses of ILIB therapy. Each course included ten sessions of ILIB treatment over ten consecutive days. During ILIB therapy, patients were inserted with a laser fiber optic needle which irradiated blood cells via a 632.8 nm Helium-Neon laser light over a period of 60 min. Pain scores were evaluated using the Visual Analogue Scale (VAS), whereas sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). These scores would be recorded both before and after each ILIB treatment course. (3) Results: The mean of all patients’ initial VAS score was 5.35. After completing three courses of ILIB treatment, the mean VAS score decreased to 2.2, which indicated a significant reduction in pain intensity. Additionally, patients experienced sleep quality improvement levels from PSQI 8.97 to 5.53 upon completion of three courses of ILIB treatment. (4) Conclusions: Intravenous Laser Irradiation of Blood (ILIB) resulted in a positive pain control effect on patients with musculoskeletal disease, especially for those with moderate to severe pain intensity (initial VAS score >4). Additionally, patients experienced better sleep quality as a result of their pain relief after receiving ILIB treatment.
Testicular Immunity and Its Connection with the Microbiota. Physiological and Clinical Implications in the Light of Personalized Medicine
Authors: Santacroce Luigi , Imbimbo Ciro , Ballini Andrea , Crocetto Felice , Scacco Salvatore , Cantore Stefania , Di Zazzo Erika , Colella Marica , Jirillo Emilio
Published: August 2022

Reproduction is a complex process, which is based on the cooperation between the endocrine–immune system and the microbiota. Testicular immunity is characterized by the so-called immune privilege, a mechanism that avoids autoimmune attacks against proteins expressed by spermatozoa. Testicular microbiota is connected with the gut microbiota, the most prevalent site of commensals inthe body. Both microbiotas take part inthe development of the immune system and protection againstpathogen invasion. Dysbiosis is caused by concurrent pathologies, such as obesity, diabetes, infections and trauma. The substitution of beneficial bacteria with pathogens may lead to destruction of spermatozoa directly or indirectly and, ultimately, to male infertility. Novel therapeutic interventions, i.e., nutritional interventions and supplementation of natural products, such as, probiotics, prebiotics, antioxidants and polyphenols, may lead to the restoration of the otherwise-impaired male reproductive potential, even if experimental and clinical results are not always concordant. In this review, the structure and immune function of the testis will be described with special reference to the blood–testisbarrier. The regulatory role of both the gut and testicular microbiota will be illustrated in health and disease, also emphasizing therapeutic attempts with natural products for the correction of male infertility, in the era of personalized medicine.
Human-Induced Pluripotent Stem Cell Technology: Toward the Future of Personalized Psychiatry
Authors: Alciati Alessandra , Reggiani Angelo , Caldirola Daniela , Perna Giampaolo
Published: August 2022

The polygenic and multifactorial nature of many psychiatric disorders has hampered implementation of the personalized medicine approach in clinical practice. However, induced pluripotent stem cell (iPSC) technology has emerged as an innovative tool for patient-specific disease modeling to expand the pathophysiology knowledge and treatment perspectives in the last decade. Current technologies enable adult human somatic cell reprogramming into iPSCs to generate neural cells and direct neural cell conversion to model organisms that exhibit phenotypes close to human diseases, thereby effectively representing relevant aspects of neuropsychiatric disorders. In this regard, iPSCs reflect patient pathophysiology and pharmacological responsiveness, particularly when cultured under conditions that emulate spatial tissue organization in brain organoids. Recently, the application of iPSCs has been frequently associated with gene editing that targets the disease-causing gene to deepen the illness pathophysiology and to conduct drug screening. Moreover, gene editing has provided a unique opportunity to repair the putative causative genetic lesions in patient-derived cells. Here, we review the use of iPSC technology to model and potentially treat neuropsychiatric disorders by illustrating the key studies on a series of mental disorders, including schizophrenia, major depressive disorder, bipolar disorder, and autism spectrum disorder. Future perspectives will involve the development of organ-on-a-chip platforms that control the microenvironmental conditions so as to reflect individual pathophysiological by adjusting physiochemical parameters according to personal health data. This strategy could open new ways by which to build a disease model that considers individual variability and tailors personalized treatments.
Changing Trends in Surgical Management of Nephrolithiasis among Young Adults: A 15-Year Population-Based Study
Authors: Zilberman Dorit E. , Erlich Tomer , Kleinmann Nir , Sabler Itay M. , Neheman Amos , Verhovsky Guy
Published: August 2022

Background: Increases in obesity and diabetes rates among all ages have led to a greater prevalence of nephrolithiasis worldwide. We aimed to explore the changing trends in surgical management of nephrolithiasis in young adults over a 15 year period. Methods: We reviewed medical records of military personnel for information on the diagnosis and care of nephrolithiasis before and during active service between 2007–2021, divided into three 5 year periods: 2007–2011, 2012–2016, and 2017–2021. Demographic, clinical, radiological, and surgical data were retrieved for the analysis of changing trends. Results: The records of 1,117,692 recruits yielded 7383 (0.66%) with stone-related surgeries, of whom 1885 were operated during military service. Their median age was 19.6 years (interquartile range [IQR] 16.8–21.2), 829 (70%) were males, and the cohort’s median body mass index was 23.6 (IQR 17.3–26.1). There was a dramatic decline in shock wave lithotripsy (SWL) prevalence (35.1%, 10.4%, and 4.4%, respectively) with a continually increasing prevalence of ureteroscopy (URS)/retrograde intrarenal surgery (RIRS) (62.7%, 88.5%, and 94.6%, p = 0.01). Percutaneous nephrolithotomy (PCNL) procedures have become nearly extinct over time (0.8% in 2017–2021). The number of median-sized stones treated by URS/RIRS increased (7.5 mm, 8.2 mm, and 9.7 mm, p = 0.044), but not those treated by SWL/PCNL. The median length of medical leave for URS/RIRS and PCNL decreased significantly (7 vs. 4 days, p = 0.05 and 10 vs. 6 days, p = 0.036, respectively), with no comparable change for SWL. There was a substantial decline in ancillary procedures in the URS/RIRS groups (9%, 6.8%, and 3.1%, p < 0.01), but not in the SWL/PCNL groups. Conclusions: Advancements in technology and surgical training are leading to the extinction of SWL and the adoption of URS/RIRS as the new standard of care for nephrolithiasis among young adults.
Endotyping of Cholesteatoma: Which Molecular Biomarkers? A Systematic Review
Authors: Cantone Elena , Di Nola Claudio , De Corso Eugenio , Cavaliere Michele , Grimaldi Giusi , Fetoni Anna Rita , Motta Gaetano
Published: August 2022

Background: So far, no medical treatment is available for cholesteatoma (C) and the only effective therapy is complete surgical removal, but recurrence is common even after surgical treatment. While C is classically divided into two clinical phenotypes, congenital and acquired, only a few studies have focused on its potential biomarkers. This study aims to revise the literature to identify which biomarkers can define the endotype of C. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process to identify published experimental articles about molecular biomarkers in C. Results: KGF and its receptor, MMP-9, KRT-1, KRT-10, and MIF might be considered biomarkers of recurrence, whereas Ki-67, TLR-4, RANKL, IL17, MMP-2, MMP-9, IL6, TNF-α, should be considered more specifically as biomarkers of bony erosion. Conclusions: These results are interesting especially from a prognostic point of view, nevertheless more studies are needed to search new biomarkers of C that could completely change not only the therapeutic standards of the disease, but also the clinical history of C itself in the era of precision medicine.
Past Human Mobility Corridors and Least-Cost Path Models South of General Carrera Lake, Central West Patagonia (46° S, South America)
Authors: Moreno-Meynard Paulo , Méndez César , Irarrázaval Iñigo , Nuevo-Delaunay Amalia
Published: August 2022

Understanding the use of natural corridors is critical for characterizing the past use of marginally occupied landscapes at the Andean fringes of western Patagonia by the hunter-gatherer groups who inhabited this region. In this paper, we combine least-cost path models and archaeological surveys and excavations to determine the possible movements along the southern margin of General Carrera Lake. The methodology includes defining uncertainties that allow for modeling a set of equiprobable routes, thereby avoiding problems with errors and biases from predictors, such as slope, land-use cover, and seasonality. The results identify mobility corridor bottlenecks, i.e., geographical areas with a high probability of travel routes with equiprobable routes that converge. In addition, we identify areas where travel routes are likely to diverge into multiple semi-parallel routes. The study of archaeological sites provides stratigraphic data to control for the chronology and characteristics of mobility along this transect. The correlation between archaeological sites and paths, specifically for the control and winter scenarios, shows the quality of these route predictions. These results indicate the repeated use of internodal spaces that were effectively incorporated into mobility during the last three millennia.
Model-Based Yield Gap Assessment in Nepal’s Diverse Agricultural Landscape
Authors: Basukala Amit Kumar , Rasche Livia
Published: August 2022

Rice, wheat, maize, millet, and barley are the five major staple cereal crops in Nepal. However, their yields are low, and imports are needed to meet domestic demand. In this study, we quantify the gap between current and potentially attainable yields in Nepal, estimate how much additional fertilizer and irrigation are required to close the gap, and assess if self-sufficiency can thus be achieved. For this, we first test the ability of the crop model EPIC to reproduce reported yields in 1999–2014 accurately. On average, simulated and reported yields at the national level were in the same range, but at the district level, the error was large, as the resolutions of the available climate and soil input data were not high enough to depict the heterogenic conditions in Nepal adequately. In the main study, we show that average yield gaps in Nepal amount to 3.0 t/ha (wheat), 2.7 t/ha (rice), 2.9 t/ha (maize), 0.4 t/ha (barley), and 0.5 t/ha (millet). With additional irrigation and fertilization, yields can be increased by 0.1/2.3 t/ha (wheat), 0.4/1.3 t/ha (rice), 1.6/1.9 t/ha (maize), 0.1/0.3 t/ha (barley), and 0.1/0.4 t/ha (millet), respectively. The results show that providing reliable and affordable access to fertilizer should be a priority for closing yield gaps in Nepal.
Old, Lost, and Forgotten Rural Materialities: Old Local Irrigation Channels and Lost Local Walking Trails
Authors: Paniagua Angel
Published: August 2022

Geo-historical studies have essentially focused on analyzing the historical evolution of the landscape and the processes of material resistance of rural landscapes against the dynamics of rural change. Historical landscapes are cumulative life micro-worlds. In the present contribution, the historical evolution of lost and disappeared rural roads and caceras—old local irrigation channels—is analyzed in a comparative way. The case studies were the Berbedillo river cacera system in the north of the province of Guadalajara and the Bustar path in the municipality of Bustarviejo in the province of Madrid. The methodology was based on a variety of research sources: written and archival documents, oral testimonies of the elderly, and micro-territorial recognition. The roads and caceras are lost but can continue to be represented, even if they can no longer be used for the life of rural communities. A new history of depopulation, restructuring, and loss is possible to (re)write based on spectral agrarian (im)materialities.
Increased Attention to Smart Development in Rural Areas: A Scientometric Analysis of Smart Village Research
Authors: Wang Qian , Luo Shixian , Zhang Jiao , Furuya Katsunori
Published: August 2022

As the research on smart cities matures and thrives, research focusing on smart rural development has also emerged into the spotlight in recent years. An increasing number of scholars have called for extending the discussion of smart development in the rural context. In response, this paper aims to conduct a comprehensive scientometric review of the current academic literature in the discussion of smart development in rural areas, centering on the concept of the smart village, which is the most recognized concept in the existing literature and practices. The contributions of this study are threefold. First, an overview of the current implementation and understanding of smart village initiatives and conceptual frameworks provides practical and theoretical insights as prerequisites for comprehending the concept. Second, to the best of our knowledge, this is the first complete scientometric study in the smart village field and will establish baseline data for future analysis and comparison. It describes the status of the scientific landscape based on quantitative analysis and an intuitive visualization, identifying patterns, hotspots, trends, and gaps. Finally, we find that the current trend puts a relatively narrow focus on the technology-driven approaches, while the dimensions of society, services, and culture have been largely neglected. Therefore, a dynamic conceptual model is proposed to call for more human-driven perspectives. We believe that a knowledge-based, community-led, and human-centric rural society is the core of a smart village ecosystem.
Impacts of Sand Mining Activities on the Wetland Ecosystem of Poyang Lake (China)
Authors: Deng Mingming , Li Qiyue , Li Wenya , Lai Geying , Pan Yue
Published: August 2022

Increasing anthropogenic activities are threatening freshwater ecosystems worldwide. Sand mining in Poyang Lake has significantly impacted the wetland ecosystem over the past 20 years, yet a quantitative analysis of these impacts remains insufficient. Here, we used 63 Landsat images taken from 2000 to 2020 along with the support vector machine (SVM) method and a retrieval model of suspended sediment concentration (SSC) to identify sand mining vessels and areas affected by sand mining. Then, we analyzed the changes in landscape patterns in the areas affected by sand mining. The potential impact of underwater noise generated by sand mining vessels on Yangtze finless porpoises was analyzed by a sound propagation model. The number of sand mining vessels in Poyang Lake during the flood, normal, and dry seasons increased from 2000 to 2016 but rapidly decreased from 2017 to 2020. Sand mining vessels were mainly distributed in the northern channel from 2000 to 2006, moved toward the center of the lake from 2007 to 2010, then moved northward in 2017. Within the areas affected by sand mining, water and mudflats declined, grassland and sandbars increased, and the landscape discontinuity increased. The habitat of the Yangtze finless porpoise affected by underwater noise from sand mining vessels in all seasons has significantly increased overtime. The mean area of the affected habitats was 70.65% (dry), 64.48% (normal), and 63.30% (flood) of the total habitat areas. The porpoise habitats in the northern channel and the west branch of the Ganjiang River are more seriously affected by the underwater noise of sand mining vessels than the southern lake. The impact of sand mining activities on wetland landscape and aquatic species demands systematic investigation in the future.
Spatiotemporal Dynamics and Driving Forces of Land Urbanization in the Yangtze River Delta Urban Agglomeration
Authors: Zhu Huxiao , Ou Xiangjun , Yang Zhen , Yang Yiwen , Ren Hongxin , Tang Le
Published: August 2022

Land urbanization is a comprehensive mapping of the relationship between urban production, life and ecology in urban space and a spatial carrier for promoting the modernization of cities. Based on the remote sensing monitoring data of the land use status of the Yangtze River Delta urban agglomeration collected in 2010 and 2020, the spatial differentiation characteristics and influencing factors of land urbanization in the area were analyzed comprehensively using hot spot analysis, kernel density estimation, the multi-scale geographically weighted regression (MGWR) model and other methods. The results indicated the following: (1) From 2010 to 2020, the average annual growth rate of land urbanization in the Yangtze River Delta urban agglomeration was 0.50%, and nearly 64.28% of the counties had an average annual growth rate that lagged behind the overall growth rate. It exhibited dynamic convergence characteristics. (2) The differentiation pattern of land urbanization in the Yangtze River Delta urban agglomeration was obvious from the southeast to the northwest. The hot spots of land urbanization were consistently concentrated in the southeastern coastal areas and showed a trend of spreading, while the cold spots were concentrated in the northwest of Anhui Province, showing a shrinking trend. (3) Compared with the GWR model and the OLS model, the MGWR model has a better fitting effect and is more suitable for studying the influencing factors of land urbanization. In addition, there were significant spatial differences in the scale and degree of influence of different influencing factors. Analyzing and revealing the spatiotemporal characteristics and driving mechanism of land urbanization in the Yangtze River Delta urban agglomeration has important theoretical value and practical significance for the scientific understanding of new-type urbanization and the implementation of regional integration and rural revitalization strategies.
The IASI Water Deficit Index to Monitor Vegetation Stress and Early Drying in Summer Heatwaves: An Application to Southern Italy
Authors: Masiello Guido , Ripullone Francesco , De Feis Italia , Rita Angelo , Saulino Luigi , Pasquariello Pamela , Cersosimo Angela , Venafra Sara , Serio Carmine
Published: August 2022

The boreal hemisphere has been experiencing increasing extreme hot and dry conditions over the past few decades, consistent with anthropogenic climate change. The continental extension of this phenomenon calls for tools and techniques capable of monitoring the global to regional scales. In this context, satellite data can satisfy the need for global coverage. The main objective we have addressed in the present paper is the capability of infrared satellite observations to monitor the vegetation stress due to increasing drought and heatwaves in summer. We have designed and implemented a new water deficit index (wdi) that exploits satellite observations in the infrared to retrieve humidity, air temperature, and surface temperature simultaneously. These three parameters are combined to provide the water deficit index. The index has been developed based on the Infrared Atmospheric Sounder Interferometer or IASI, which covers the infrared spectral range 645 to 2760 cm−1 with a sampling of 0.25 cm−1. The index has been used to study the 2017 heatwave, which hit continental Europe from May to October. In particular, we have examined southern Italy, where Mediterranean forests suffer from climate change. We have computed the index’s time series and show that it can be used to indicate the atmospheric background conditions associated with meteorological drought. We have also found a good agreement with soil moisture, which suggests that the persistence of an anomalously high water deficit index was an essential driver of the rapid development and evolution of the exceptionally severe 2017 droughts.
Evaluating the Effect of the Location and Design of Retention Ponds on Flooding in a Peri-Urban River Catchment
Authors: Birkinshaw Stephen J. , Krivtsov Vladimir
Published: August 2022

In order to reduce the flooding risk in urban and peri-urban river catchments, retention ponds or wet detention ponds are often used. However, there has been little work that uses distributed hydrological modeling to consider their optimum location and design in order to reduce the flood risk in a river catchment. This work considers two existing and two potential ponds in the 22.8 km2 Braid Burn catchment, Edinburgh, Scotland. Using the Shetran physically based distributed hydrological model, the effect of these ponds on the river discharges for eight measured rainfall events and two design rainfall events is considered. The results show the larger Blackford pond is best at reducing the peak discharge at the catchment outlet. The other three ponds are designed to be almost the same. The potential pond in the upper part of the catchment reduces the peak discharge at the outlet; the pond in the middle at Oxgangs makes little difference to the peak discharge, while the potential pond in the lower part of the catchment increases the peak discharge at the outlet. These results show that when considering flood risk, the location of a retention pond within a river catchment is important, and it can make the flooding worse at the outlet if it is located in the wrong location. This work suggests the pond should be located in the upper part of the catchment, although the ideal location will depend on the catchment’s shape and lag time.
The Verbal Phrase in Paraguayan Guarani: A Case Study on the Role of Prosody in Linearization
Authors: Zubizarreta Maria Luisa
Published: August 2022

This paper examines in detail the morpho-syntax of the verbal phrase in Paraguayan Guarani, in root and complement clauses, and argues that while the ordering relation between the verb and its associated functional morphemes is congruent with the syntax (cf. the Mirror Principle), the ordering of post-verbal arguments is best understood in terms of phonological linearization. More specifically, it is argued that there are language-particular prosodic requirements that force the post-verbal arguments to be phonologically linearized outside the accentual domain defined by the verb and its associated functional morphemes.
The Biotics Family: Current Knowledge and Future Perspectives in Metabolic Diseases
Authors: Palade Codrina-Madalina , Vulpoi Georgiana-Anca , Vulpoi Radu-Alexandru , Drug Vasile Liviu , Barboi Oana-Bogdana , Ciocoiu Manuela
Published: August 2022

Globally, metabolic diseases such as obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease pose a major public health threat. Many studies have confirmed the causal relationship between risk factors and the etiopathogenesis of these diseases. Despite this, traditional therapeutic management methods such as physical education and diet have proven insufficient. Recently, researchers have focused on other potential pathways for explaining the pathophysiological variability of metabolic diseases, such as the involvement of the intestinal microbiota. An understanding of the relationship between the microbiome and metabolic diseases is a first step towards developing future therapeutic strategies. Currently, much attention is given to the use of biotics family members such as prebiotics (lactolose, soy oligosaccharides, galactooligosaccharides, xylooligosaccharides or inulin) and probiotics (genera Lactobacillus, Bifidobacterium, Lactococcus, Streptococcus or Enterococcus). They can be used both separately and together as synbiotics. Due to their direct influence on the composition of the intestinal microbiota, they have shown favorable results in the evolution of metabolic diseases. The expansion of the research area in the biotics family has led to the discovery of new members, like postbiotics. In the age of personalized medicine, their use as therapeutic options is of great interest to our study.
The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea
Authors: Seo Il Hyeok , Lee Jeongwoo , Na Dasom , Kyung Hyunhye , Yang Jieun , Lee Sangbong , Jeon Sang June , Choi Jae Won , Lee Kyu Young , Yi Jungyu , Han Jaehwan , Yoo Mooyoung , Kim Se Hyun
Published: August 2022

Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world. In Korea, development of the proton linear accelerator-based BNCT system has completed development, and its anti-cancer effect in the U-87 MG subcutaneous xenograft model has been evaluated. To evaluate the efficacy of BNCT, we measured 10B-enriched boronophenylalanine (BPA) uptake in U-87 MG, FaDu, and SAS cells and evaluated cell viability by clonogenic assays. In addition, the boron concentration in the tumor, blood, and skin on the U-87 MG xenograft model was measured, and the tumor volume was measured for 4 weeks after BNCT. In vitro, the intracellular boron concentration was highest in the order of SAS, FaDu, and U-87 MG, and cell survival fractions decreased depending on the BPA treatment concentration and neutron irradiation dose. In vivo, the tumor volume was significantly decreased in the BNCT group compared to the control group. This study confirmed the anti-cancer effect of BNCT in the U-87 MG subcutaneous xenograft model. It is expected that the proton linear accelerator-based BNCT system developed in Korea will be a new option for radiation therapy for cancer treatment.
Sources of Nitrogen-, Sulfur-, and Phosphorus-Containing Feedstocks for Prebiotic Chemistry in the Planetary Environment
Authors: Todd Zoe R.
Published: August 2022

Biochemistry on Earth makes use of the key elements carbon, hydrogen, oxygen, nitrogen, phosphorus, and sulfur (or CHONPS). Chemically accessible molecules containing these key elements would presumably have been necessary for prebiotic chemistry and the origins of life on Earth. For example, feedstock molecules including fixed nitrogen (e.g., ammonia, nitrite, nitrate), accessible forms of phosphorus (e.g., phosphate, phosphite, etc.), and sources of sulfur (e.g., sulfide, sulfite) may have been necessary for the origins of life, given the biochemistry seen in Earth life today. This review describes potential sources of nitrogen-, sulfur-, and phosphorus-containing molecules in the context of planetary environments. For the early Earth, such considerations may be able to aid in the understanding of our own origins. Additionally, as we learn more about potential environments on other planets (for example, with upcoming next-generation telescope observations or new missions to explore other bodies in our Solar System), evaluating potential sources for elements necessary for life (as we know it) can help constrain the potential habitability of these worlds.
Dental and Periodontal Health in Acute Intermittent Porphyria
Authors: Storjord Elin , Airila-Månsson Stella , Karlsen Katarzyna , Madsen Martin , Dahl Jim André , Landsem Anne , Fure Hilde , Ludviksen Judith Krey , Fjøse Johannes Østrem , Dickey Amy K. , Karlsen Bård Ove , Waage Nielsen Erik , Mollnes Tom Eirik , Brekke Ole-Lars
Published: August 2022

In the inherited metabolic disorder acute intermittent porphyria (AIP), high sugar intake prevents porphyric attacks due to the glucose effect and the following high insulin levels that may lower AIP disease activity. Insulin resistance is a known risk factor for periodontitis and sugar changes diabetogenic hormones and affects dental health. We hypothesized differences in homeostasis model assessment (HOMA) scores for insulin resistance in AIP cases vs. controls and in those with periodontitis. Our aim was to systematically study dental health in AIP as poor dental health was previously only described in case reports. Further, we aimed to examine if poor dental health and kidney failure might worsen AIP as chronic inflammation and kidney failure might increase disease activity. In 47 AIP cases and 47 matched controls, X-rays and physical examination of clinical attachment loss (CAL), probing pocket depth (PPD), and decayed missing filled teeth (DMFT) were performed. Dietary intake was evaluated through a diet logbook. Plasma cytokines and diabetogenic hormones were measured using multiplex technology and urine porphobilinogen and kidney and liver function by routine methods. An excel spreadsheet from the University of Oxford was used to estimate HOMA scores; beta cell function, HOMA%B (%B), insulin sensitivity, HOMA%S (%S), and insulin resistance HOMA-IR (IR), based on glucose and plasma (P) C-peptide. The Wilcoxon matched-pairs signed rank test, the Mann–Whitney U-test, and Spearman’s non-parametric correlation were used. Insulin (p = 0.007) and C-peptide (p = 0.006) were higher in the AIP cases with periodontitis versus those without. In AIP patients, the liver fibrosis index 4 correlated with DMFT (p < 0.001) and CAL ≥4 mm (p = 0.006); the estimated glomerular filtration rate correlated with DMFT (p < 0.001) and CAL ≥4 mm (p = 0.02). CAL ≥4 mm was correlated with chemokine ligand 11 and interleukin (IL)-13 (p = 0.04 for both), and PPD >5 mm was correlated with plasminogen activator inhibitor-1 (p = 0.003) and complement component 3 (p = 0.02). In conclusion, dental health in AIP cases was correlated with insulin resistance, inflammatory markers, and biomarkers of kidney and liver function, demonstrating that organ damage in the kidney and liver are associated with poorer dental health.