bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 3 from A Preclinical Mouse Model of Invasive Lobular Breast Cancer Metastasis
Authors: Doornebal Chris W. , Klarenbeek Sjoerd , Braumuller Tanya M. , Klijn Christiaan N. , Ciampricotti Metamia , Hau Cheei-Sing , Hollmann Markus W. , Jonkers Jos , de Visser Karin E.
Published: April 2023

PDF file - 385K, S3. Recipient mammary tumors and distant metastases exhibit very similar genomic profiles.
Supplementary Figure 3 from DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas
Authors: Fukawa Tomoya , Ono Masaya , Matsuo Taisuke , Uehara Hisanori , Miki Tsuneharu , Nakamura Yusuke , Kanayama Hiro-omi , Katagiri Toyomasa
Published: April 2023

PDF file - 1MB, Effects of DDX31 knockdown on p53 and p21 expression at the mRNA and protein levels. The cells were harvested and examined by quantitative RT-PCR at 48h (A) and 72h after transfection (B). (C) western blot analysis with the indicated antibodies at 72h after transfection
Supplementary Methods from Dermatan Sulfate Is Involved in the Tumorigenic Properties of Esophagus Squamous Cell Carcinoma
Authors: Thelin Martin A. , Svensson Katrin J. , Shi Xiaofeng , Bagher Mariam , Axelsson Jakob , Isinger-Ekstrand Anna , van Kuppevelt Toin H. , Johansson Jan , Nilbert Mef , Zaia Joseph , Belting Mattias , Maccarana Marco , Malmström Anders
Published: April 2023

PDF file - 84K
Supplementary Figure S3 from Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks
Authors: Shen Changxian , Oswald Duane , Phelps Doris , Cam Hakan , Pelloski Christopher E. , Pang Qishen , Houghton Peter J.
Published: April 2023

Supplementary Figure S3 - PDF file 2191K, The mTOR Pathway Regulates ATM Checkpoint in Response to ICL via Sustaining FANCD2 in Rh30 Cells. A, model of the control of FANCD2 by PI3K-Akt-mTORC1-S6K1 axis. B, a hypothetic model of the regulation of ATM checkpoint activation and DNA damage repair in response to ICL by mTOR signaling
Supplementary Figure 2 from Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner
Authors: Mace Thomas A. , Ameen Zeenath , Collins Amy , Wojcik Sylwia , Mair Markus , Young Gregory S. , Fuchs James R. , Eubank Tim D. , Frankel Wendy L. , Bekaii-Saab Tanios , Bloomston Mark , Lesinski Gregory B.
Published: April 2023

PDF file - 1835K, Supplementary Figure S2. PSC supernatants do not signal through STAT1 and STAT5.
Supplementary Table 5 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: April 2023

XLS file - 21K, Ingenuity Pathway Analysis for Functional Networks
Supplementary Figure Legends 1-6, Table Legends 1-6 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: April 2023

PDF file - 81K
Supplementary Figure 1 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: April 2023

PDF file - 154K, Negative regulators of melanoma chemoresistance include known melanoma oncogenes
Supplementary Figure Legends 1-4 from PD-1 Blockade Enhances T-cell Migration to Tumors by Elevating IFN-γ Inducible Chemokines
Authors: Peng Weiyi , Liu Chengwen , Xu Chunyu , Lou Yanyan , Chen Jieqing , Yang Yan , Yagita Hideo , Overwijk Willem W. , Lizée Gregory , Radvanyi Laszlo , Hwu Patrick
Published: April 2023

PDF file - 57K
Supplementary Video 1 from The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
Authors: Khaitan Divya , Dinger Marcel E. , Mazar Joseph , Crawford Joanna , Smith Martin A. , Mattick John S. , Perera Ranjan J.
Published: April 2023

Supplementary Video 1 from The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
Supplementary Methods from The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
Authors: Khaitan Divya , Dinger Marcel E. , Mazar Joseph , Crawford Joanna , Smith Martin A. , Mattick John S. , Perera Ranjan J.
Published: April 2023

Supplementary Methods from The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
Supplementary Figure 1 from PD-1 Blockade Enhances T-cell Migration to Tumors by Elevating IFN-γ Inducible Chemokines
Authors: Peng Weiyi , Liu Chengwen , Xu Chunyu , Lou Yanyan , Chen Jieqing , Yang Yan , Yagita Hideo , Overwijk Willem W. , Lizée Gregory , Radvanyi Laszlo , Hwu Patrick
Published: April 2023

PDF file - 50K, The expression of PD-1 by non-transferred T cells at the tumor and spleen of mice receiving ACT treatment
Supplementary Tables 1 - 3 from Oncogenic NRAS, Required for Pathogenesis of Embryonic Rhabdomyosarcoma, Relies upon the HMGA2–IGF2BP2 Pathway
Authors: Li Zhizhong , Zhang Yunyu , Ramanujan Krishnan , Ma Yan , Kirsch David G. , Glass David J.
Published: April 2023

PDF file - 36K, List of top 100 genes down-regulated and top 100 genes up-regulated by HMGA2 shRNA in the RD rhabdomyosarcoma cell line (S1); List of Top 100 mRNAs bound by IGF2BP2 in the human 293 cell line (S2); List of GEO Databases used to analyze the expression of HMGA2 and HMGA1 mRNA levels in normal tissues (S3).
Supplementary Figure 2 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
Authors: Alain Tommy , Morita Masahiro , Fonseca Bruno D. , Yanagiya Akiko , Siddiqui Nadeem , Bhat Mamatha , Zammit Domenick , Marcus Victoria , Metrakos Peter , Voyer Lucie-Anne , Gandin Valentina , Liu Yi , Topisirovic Ivan , Sonenberg Nahum
Published: April 2023

PDF file - 2.7MB, Figure S2 contains data that show that cells with reduced levels of 4E-BP1/2 have increased resistance to the anti-neoplastic effects of PP242.
Supplementary Figure 1 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
Authors: Alain Tommy , Morita Masahiro , Fonseca Bruno D. , Yanagiya Akiko , Siddiqui Nadeem , Bhat Mamatha , Zammit Domenick , Marcus Victoria , Metrakos Peter , Voyer Lucie-Anne , Gandin Valentina , Liu Yi , Topisirovic Ivan , Sonenberg Nahum
Published: April 2023

PDF file - 2.1MB, Figure S1 contains data that show that cells acquire resistance to the anti-proliferative effects of PP242 by downregulating 4E-BP1 and 2
Supplementary Figure Legends from LIN28 Expression in Malignant Germ Cell Tumors Downregulates let-7 and Increases Oncogene Levels
Authors: Murray Matthew J. , Saini Harpreet K. , Siegler Charlotte A. , Hanning Jennifer E. , Barker Emily M. , van Dongen Stijn , Ward Dawn M. , Raby Katie L. , Groves Ian J. , Scarpini Cinzia G. , Pett Mark R. , Thornton Claire M. , Enright Anton J. , Nicholson James C. , Coleman Nicholas
Published: April 2023

PDF - 59K.
Supplementary Table 1 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants
Authors: Kluza Jérome , Corazao-Rozas Paola , Touil Yasmine , Jendoubi Manel , Maire Cyril , Guerreschi Pierre , Jonneaux Aurélie , Ballot Caroline , Balayssac Stéphane , Valable Samuel , Corroyer-Dulmont Aurélien , Bernaudin Myriam , Malet-Martino Myriam , de Lassalle Elisabeth Martin , Maboudou Patrice , Formstecher Pierre , Polakowska Renata , Mortier Laurent , Marchetti Philippe
Published: April 2023

PDF file - 57K, on clinical information
Supplementary Figure 2 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5
Authors: Romagnoli Mathilde , Belguise Karine , Yu Ziyang , Wang Xiaobo , Landesman-Bollag Esther , Seldin David C. , Chalbos Dany , Barillé-Nion Sophie , Jézéquel Pascal , Seldin Margaret L. , Sonenshein Gail E.
Published: April 2023

PDF file - 168K, Blimp-1 knockdown with siBlimp1-2 represses the migratory properties of MDA-MB-231 breast cancer cells
Supplementary Figure 5 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants
Authors: Kluza Jérome , Corazao-Rozas Paola , Touil Yasmine , Jendoubi Manel , Maire Cyril , Guerreschi Pierre , Jonneaux Aurélie , Ballot Caroline , Balayssac Stéphane , Valable Samuel , Corroyer-Dulmont Aurélien , Bernaudin Myriam , Malet-Martino Myriam , de Lassalle Elisabeth Martin , Maboudou Patrice , Formstecher Pierre , Polakowska Renata , Mortier Laurent , Marchetti Philippe
Published: April 2023

PDF file - 322K, Showing the effect of siRNA PDK3, elesclomol and the combination DCA plus elesclomol on melanoma cell viability
Supplementary Figure 1 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5
Authors: Romagnoli Mathilde , Belguise Karine , Yu Ziyang , Wang Xiaobo , Landesman-Bollag Esther , Seldin David C. , Chalbos Dany , Barillé-Nion Sophie , Jézéquel Pascal , Seldin Margaret L. , Sonenshein Gail E.
Published: April 2023

PDF file - 167K, Blimp-1 is induced by TGF-beta1 and required for TGF-beta1-induced EMT signature in Hs578T breast cancer cells
Supplementary Figure 3 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants
Authors: Kluza Jérome , Corazao-Rozas Paola , Touil Yasmine , Jendoubi Manel , Maire Cyril , Guerreschi Pierre , Jonneaux Aurélie , Ballot Caroline , Balayssac Stéphane , Valable Samuel , Corroyer-Dulmont Aurélien , Bernaudin Myriam , Malet-Martino Myriam , de Lassalle Elisabeth Martin , Maboudou Patrice , Formstecher Pierre , Polakowska Renata , Mortier Laurent , Marchetti Philippe
Published: April 2023

PDF file - 126K, Showing the effect of YC-1 and DCA on PDH activity in A375 and LND cell lines
Supplementary Methods, Table 1 from Reconsidering the Paradigm of Cancer Immunotherapy by Computationally Aided Real-time Personalization
Authors: Kogan Yuri , Halevi–Tobias Karin , Elishmereni Moran , Vuk-Pavlović Stanimir , Agur Zvia
Published: April 2023

PDF file - 201K, The contents of the document: 1. Model equations for the vaccine and the maturing DCs 2. Formal description of the algorithm for in-treatment therapy personalization 3. Success-of-validation criteria 4. Model comparison grade and parameters for SOV criterion 5. Selecting the best performing SOV criterion 6. Table S1
Supplementary Figure 5 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: April 2023

PDF file, 325K, Data completing Figure 4.
Supplementary Figure 10 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: April 2023

PDF file, 187K, S-3B truncated for its LEO domain lost its protective capacities.
Supplementary Figure 1 from Chemotherapy Acts as an Adjuvant to Convert the Tumor Microenvironment into a Highly Permissive State for Vaccination-Induced Antitumor Immunity
Authors: Kang Tae Heung , Mao Chih-Ping , Lee Sung Yong , Chen Alexander , Lee Ji-Hyun , Kim Tae Woo , Alvarez Ronald D. , Roden Richard B.S. , Pardoll Drew , Hung Chien-Fu , Wu T.-C.
Published: April 2023

PDF file - 2862K, Immune response and disease outcome in tumor-bearing mice treated with chemotherapy and intratumor injection of protein
Supplementary Figures 1 - 9 from The Major Reverse Transcriptase–Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Authors: Listerman Imke , Sun Jie , Gazzaniga Francesca S. , Lukas Jason L. , Blackburn Elizabeth H.
Published: April 2023

PDF file - 236K, S1. hTERT and SRSF3 splice variant enrichment after cycloheximide treatment. S2. Total SRSF3 and hTERT splice variant mRNA abundance in ribosome-containing fractions. S3. Unaltered microscopy image shown in Figure 3. S4. SRSF11 and hnRNPH2 binding sites in pSpliceExpress-hTERT. S5. hTR 3' end co-immunoprecipitates with FLAG-WT-hTERT, FLAG-D868A-hTERT and FLAG-β-deletion. S6. hTERT detection by Western blot in UM-UC-3 lysates from experiment 5C. S7. hTR RNA expression levels in breast cancer cell lines. S8. Modal telomere length stayed relatively constant after 20 continues passages in randomly selected breast cell lines. S9. Telomerase activity and relative expression of hTERT α+β+ and β-deletion mRNAs in breast cancer cell line subtypes.
Supplementary Table 2 from Genetic and Pharmacological Strategies to Refunctionalize the von Hippel Lindau R167Q Mutant Protein
Authors: Ding Zhiyong , German Peter , Bai Shanshan , Reddy A. Srinivas , Liu Xian-De , Sun Mianen , Zhou Lijun , Chen Xiaohua , Zhao Xiaobei , Wu Chengbiao , Zhang Shuxing , Mills Gordon B. , Jonasch Eric
Published: April 2023

XLSX file - 13KB, Folding Free Energy (deltadeltaG) of VHL missense mutations computed using the PoPMuSiC program.
Supplementary Tables 1 - 7 from A Meta-analysis of Lung Cancer Gene Expression Identifies PTK7 as a Survival Gene in Lung Adenocarcinoma
Authors: Chen Ron , Khatri Purvesh , Mazur Pawel K. , Polin Melanie , Zheng Yanyan , Vaka Dedeepya , Hoang Chuong D. , Shrager Joseph , Xu Yue , Vicent Silvestre , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: April 2023

XLSX file - 40KB, Data sets used in discovery meta-analysis (S1). Data sets used in validation meta-analysis (S2). Gene-level results in validation meta-analysis (S3). Data sets used in NSCLC histological subtype meta-analysis (S4). Gene-level results in NSCLC histological subtype (ADC vs SCC) meta-analysis (S5). Tissue microarray specimen annotations and PTK7 staining results (S6). Cell line annotations (S7).
Supplementary Figure 2 from Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2
Authors: Lopez-Rivera Esther , Jayaraman Padmini , Parikh Falguni , Davies Michael A. , Ekmekcioglu Suhendan , Izadmehr Sudeh , Milton Denái R. , Chipuk Jerry E. , Grimm Elizabeth A. , Estrada Yeriel , Aguirre-Ghiso Julio , Sikora Andrew G.
Published: April 2023

PDF file - 76K, In MT-RET-1 mouse melanoma cell line we transient trafected with with siRNA-iNOS human, after 48 hours MT-RET-1 mouse cell lysate were subjected to SDS-PAGE and western blot analysis for iNOS, and actin as a loading control.
Supplementary Figure S1 from Whole-Genome Sequencing of Asian Lung Cancers: Second-Hand Smoke Unlikely to Be Responsible for Higher Incidence of Lung Cancer among Asian Never-Smokers
Authors: Krishnan Vidhya G. , Ebert Philip J. , Ting Jason C. , Lim Elaine , Wong Swee-Seong , Teo Audrey S.M. , Yue Yong G. , Chua Hui-Hoon , Ma Xiwen , Loh Gary S.L. , Lin Yuhao , Tan Joanna H.J. , Yu Kun , Zhang Shenli , Reinhard Christoph , Tan Daniel S.W. , Peters Brock A. , Lincoln Stephen E. , Ballinger Dennis G. , Laramie Jason M. , Nilsen Geoffrey B. , Barber Thomas D. , Tan Patrick , Hillmer Axel M. , Ng Pauline C.
Published: April 2023

Validation of mutation signatures based on somatic variants, identified via RNA sequencing, among 83 Korean lung adenocarcinoma patients (47 smokers and 36 never-smokers) in another study [28].
Supplementary Methods from An Antibody–Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors
Authors: Breij Esther C.W. , de Goeij Bart E.C.G. , Verploegen Sandra , Schuurhuis Danita H. , Amirkhosravi Ali , Francis John , Miller Vibeke Breinholt , Houtkamp Mischa , Bleeker Wim K. , Satijn David , Parren Paul W.H.I.
Published: April 2023

PDF file - 27K, Antibody cross-competition studies; Alphascreen Assay to detect ERK phosphorylation.
Supplementary Figure 8 from NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells
Authors: Kottakis Filippos , Foltopoulou Parthena , Sanidas Ioannis , Keller Patricia , Wronski Ania , Dake Benjamin T. , Ezell Scott A. , Shen Zhu , Naber Stephen P. , Hinds Philip W. , McNiel Elizabeth , Kuperwasser Charlotte , Tsichlis Philip N.
Published: April 2023

PDF file - 91KB, The knockdown of NDY1/KDM2B is not rescued by exogenous BMI1.
Supplementary Figure 2 from NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells
Authors: Kottakis Filippos , Foltopoulou Parthena , Sanidas Ioannis , Keller Patricia , Wronski Ania , Dake Benjamin T. , Ezell Scott A. , Shen Zhu , Naber Stephen P. , Hinds Philip W. , McNiel Elizabeth , Kuperwasser Charlotte , Tsichlis Philip N.
Published: April 2023

PDF file - 867KB, NDY1/KDM2B is required for cellular transformation by RAS-G12V.
Supplementary Figure 5 from Activation of the NOTCH Pathway in Head and Neck Cancer
Authors: Sun Wenyue , Gaykalova Daria A. , Ochs Michael F. , Mambo Elizabeth , Arnaoutakis Demetri , Liu Yan , Loyo Myriam , Agrawal Nishant , Howard Jason , Li Ryan , Ahn Sun , Fertig Elana , Sidransky David , Houghton Jeffery , Buddavarapu Kalyan , Sanford Tiffany , Choudhary Ashish , Darden Will , Adai Alex , Latham Gary , Bishop Justin , Sharma Rajni , Westra William H. , Hennessey Patrick , Chung Christine H. , Califano Joseph A.
Published: April 2023

PDF file - 68K, Growth effects of HEY1 siRNA inhibition in HNSCC cells with wildtype NOTCH1 status. HEY1 was downregulated in UPCI-SCC090 and SCC61 by siRNA as described in methods. The effect of siHEY1 on the expression of HEY1 is shown on the left. The effect of HEY1 downregulation on cell proliferation for these two cell lines is shown on the right. Note, there is over 90% transfection efficiency of HEY1 downregulation for each cell line, however the strong growth inhibition effect was shown only for NOTCH1 wildtype 090 cell line.
Supplementary Figure 6 from HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
Authors: Cheng Guangcun , Sun Xueqing , Wang Jinglong , Xiao Gang , Wang Xiumin , Fan Xuemei , Zu Lidong , Hao Mingang , Qu Qing , Mao Yan , Xue Yunjing , Wang Jianhua
Published: April 2023

PDF file - 142K, The AKT signaling pathway is partly inactivated after NGALR knockdown.
Supplementary Figure 1 from HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
Authors: Cheng Guangcun , Sun Xueqing , Wang Jinglong , Xiao Gang , Wang Xiumin , Fan Xuemei , Zu Lidong , Hao Mingang , Qu Qing , Mao Yan , Xue Yunjing , Wang Jianhua
Published: April 2023

PDF file - 623K, Effects of restoring HIC1 expression in MDA-468 cells.
Fig S3 from The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development
Authors: Venkateswaran Amudhan , Sekhar Konjeti R. , Levic Daniel S. , Melville David B. , Clark Travis A. , Rybski Witold M. , Walsh Alexandra J. , Skala Melissa C. , Crooks Peter A. , Knapik Ela W. , Freeman Michael L.
Published: April 2023

PDF file 3827K, Characterization of Enox1 morphants
Fig S1 from The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development
Authors: Venkateswaran Amudhan , Sekhar Konjeti R. , Levic Daniel S. , Melville David B. , Clark Travis A. , Rybski Witold M. , Walsh Alexandra J. , Skala Melissa C. , Crooks Peter A. , Knapik Ela W. , Freeman Michael L.
Published: April 2023

PDF file140K, Characterization of ENOX1 antibody
Supplementary Figure 6 from RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma
Authors: Lam Adeline R. , Le Bert Nina , Ho Samantha S.W. , Shen Yu J. , Tang Melissa L.F. , Xiong Gordon M. , Croxford J. Ludovic , Koo Christine X. , Ishii Ken J. , Akira Shizuo , Raulet David H. , Gasser Stephan
Published: April 2023

PDF file - 268K, Stainings of cytosolic DNA in Ara-C treated BC2 cells and Yac-1 cells in the presence of caffeine.
Data Supplement from Osteopontin Shapes Immunosuppression in the Metastatic Niche
Authors: Sangaletti Sabina , Tripodo Claudio , Sandri Sara , Torselli Ilaria , Vitali Caterina , Ratti Chiara , Botti Laura , Burocchi Alessia , Porcasi Rossana , Tomirotti Andrea , Colombo Mario P. , Chiodoni Claudia
Published: April 2023

Supplemental Figure 4. Activation state of T cells in the lungs from WT and Spp1-/- tumor bearing mice and Spp1 expression by the different leukocyte subsets sorted from lungs.
Supplementary Figure 4 from RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma
Authors: Lam Adeline R. , Le Bert Nina , Ho Samantha S.W. , Shen Yu J. , Tang Melissa L.F. , Xiong Gordon M. , Croxford J. Ludovic , Koo Christine X. , Ishii Ken J. , Akira Shizuo , Raulet David H. , Gasser Stephan
Published: April 2023

PDF file - 400K, Specificity control of cytosolic DNA stainings.
Supplementary Figure 3 from RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma
Authors: Lam Adeline R. , Le Bert Nina , Ho Samantha S.W. , Shen Yu J. , Tang Melissa L.F. , Xiong Gordon M. , Croxford J. Ludovic , Koo Christine X. , Ishii Ken J. , Akira Shizuo , Raulet David H. , Gasser Stephan
Published: April 2023

PDF file - 184K, Inhibition of ATM and ATR impairs upregulation of RAE1 and phosphorylation of IRF3 and TBK1.
Supplementary Methods from CRR9/CLPTM1L Regulates Cell Survival Signaling and Is Required for Ras Transformation and Lung Tumorigenesis
Authors: James Michael A. , Vikis Haris G. , Tate Everett , Rymaszewski Amy L. , You Ming
Published: April 2023

PDF file - 48K
Supplementary Figure 6 from CRR9/CLPTM1L Regulates Cell Survival Signaling and Is Required for Ras Transformation and Lung Tumorigenesis
Authors: James Michael A. , Vikis Haris G. , Tate Everett , Rymaszewski Amy L. , You Ming
Published: April 2023

PDF file - 157K, Proliferative Effect of CLPTM1L Depletion in Lung Tumor and Immortalized Bronchial Epithelial Cells.
Supplementary Table 2 from Identification of a Cyclin D1 Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint
Authors: Ju Xiaoming , Casimiro Mathew C. , Gormley Michael , Meng Hui , Jiao Xuanmao , Katiyar Sanjay , Crosariol Marco , Chen Ke , Wang Min , Quong Andrew A. , Lisanti Michael P. , Ertel Adam , Pestell Richard G.
Published: April 2023

XLSX file - 118K, Functional annotation clustering of cyclin D1 induced genes.
Supplementary Figure 2 from CRR9/CLPTM1L Regulates Cell Survival Signaling and Is Required for Ras Transformation and Lung Tumorigenesis
Authors: James Michael A. , Vikis Haris G. , Tate Everett , Rymaszewski Amy L. , You Ming
Published: April 2023

PDF file - 82K, Waterfall plot of relative CLPTM1L expression.
Supplementary Figures S1-S4 from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Authors: Yuzefovych Larysa V. , Kahn Andrea G. , Schuler Michele A. , Eide Lars , Arora Ritu , Wilson Glenn L. , Tan Ming , Rachek Lyudmila I.
Published: April 2023

Representative images of each genotype of PyMT mice with mammary tumors obtained from 12-16-week old female (S1); Histological sections of the lungs from PyMT mice of different OGG1 genotypes (S2); OGG1 activity in mammary tumors isolated from B-nuclear, and D- mitochondrial fractions from PyMT/KO and PyMT/Tg animals (S3); LDH activity in mammary tumors isolated from PyMT/KO, PyMT/WT, PyMT/Tg and PyMT/ KOTg mice (S4).
Supplementary Figure 2 from Genetic Mutation of p53 and Suppression of the miR-17∼92 Cluster Are Synthetic Lethal in Non–Small Cell Lung Cancer due to Upregulation of Vitamin D Signaling
Authors: Borkowski Robert , Du Liqin , Zhao Zhenze , McMillan Elizabeth , Kosti Adam , Yang Chin-Rang , Suraokar Milind , Wistuba Ignacio I. , Gazdar Adi F. , Minna John D. , White Michael A. , Pertsemlidis Alexander
Published: April 2023

Supplementary Figure 2. Expression and response in cells derived from a mouse model of adenocarcinoma.
Supplemental Figure 3 from BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells
Authors: Alford Sarah E. , Kothari Anisha , Loeff Floris C. , Eichhorn Joshua M. , Sakurikar Nandini , Goselink Henriette M. , Saylors Robert L. , Jedema Inge , Falkenburg J.H. Frederik , Chambers Timothy C.
Published: April 2023

Supplemental Figure 3: BH3 mimetics induce rapid apoptotic death in primary ALL cells.
Supplementary Table S2 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: April 2023

Primers used for amplification and Illumina® sequencing of genomic DNA samples from shRNA screens.
Supplementary Figures 1 - 3 from HOXB7 Promotes Malignant Progression by Activating the TGFβ Signaling Pathway
Authors: Liu Shou , Jin Kideok , Hui Yvonne , Fu Jie , Jie Chunfa , Feng Sheng , Reisman David , Wang Qian , Fan Daping , Sukumar Saraswati , Chen Hexin
Published: April 2023

Fig. S1. TGF-β/SMAD3 signaling mediates the promotion of migration and invasion by HOXB7. Fig. S2 Effects of HOXB7 overexpression and TGF-β2 knockdown on cellular morphology and proliferation rate. Fig. S3 Effects of HOXB7 overexpression on cellular morphology and proliferation rate of Her2 mouse mammary tumor cell line, H605
Supplemental Methods from miR-339-3p Is a Tumor Suppressor in Melanoma
Authors: Weber Claudia E.M. , Luo Chonglin , Hotz-Wagenblatt Agnes , Gardyan Adriane , Kordaß Theresa , Holland-Letz Tim , Osen Wolfram , Eichmüller Stefan B.
Published: April 2023

Transfection of melanoma cells with small nucleotides; isolation of total RNA; reverse transcription and qPCR; luciferase reporter assay; Western blot analysis; bioinformatics; statistics.
Supplementary Figure S1 from β-Catenin Promotes Regulatory T-cell Responses in Tumors by Inducing Vitamin A Metabolism in Dendritic Cells
Authors: Hong Yuan , Manoharan Indumathi , Suryawanshi Amol , Majumdar Tanmay , Angus-Hill Melinda L. , Koni Pandelakis A. , Manicassamy Balaji , Mellor Andrew L. , Munn David H. , Manicassamy Santhakumar
Published: April 2023

Supplementary Figure S1. Pharmacological inhibition of retinoic acid synthesis limits tumor growth and T regulatory cell induction.
Supplementary Tables S1-S5 from Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility
Authors: Escobar-Hoyos Luisa F. , Shah Ruchi , Roa-Peña Lucia , Vanner Elizabeth A. , Najafian Nilofar , Banach Anna , Nielsen Erik , Al-Khalil Ramsey , Akalin Ali , Talmage David , Shroyer Kenneth R.
Published: April 2023

Comparison between discovery- and validation-datasets (S1); Comparison between the hazard ratio and survival probability estimated for the discovery, validation and combined datasets on K17 as a prognostic marker in squamous cell carcinomas of the cervix (S2); Primers and probes used for qRT-PCR (S3); Primary antibodies used for western blotting (S4); Failure hazard for cervical cancer patients stratified by K17 status, p27KIP1 status, and combined status using a Cox proportional hazards model (S5).
Supplementary Figures S1-S5 from Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility
Authors: Escobar-Hoyos Luisa F. , Shah Ruchi , Roa-Peña Lucia , Vanner Elizabeth A. , Najafian Nilofar , Banach Anna , Nielsen Erik , Al-Khalil Ramsey , Akalin Ali , Talmage David , Shroyer Kenneth R.
Published: April 2023

Endogenous expression of K17 in cervical cancer cell lines and knockdown efficiency by siRNAs and shRNAs against K17 in SiHa and CaSki cells (S1); K17 knockdown induces cell-cycle arrest at G1 (S2); K17 knockdown induces p27KIP1 nuclear accumulation (S3); p27KIP1-ubiquitin ligases expression is not altered by K17 knockdown (S4); K17 interacts with p27KIP1 in the nucleus (S5).
Supplementary Table 1 from Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression
Authors: Yao Lu , Han Chang , Song Kyoungsub , Zhang Jinqiang , Lim Kyu , Wu Tong
Published: April 2023

Supplementary Table 1: Primer sequences.
Supplementary Figures S1-4 from Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression
Authors: Yao Lu , Han Chang , Song Kyoungsub , Zhang Jinqiang , Lim Kyu , Wu Tong
Published: April 2023

Supplementary Figure S1. Ï‰-3 PUFAs induce 15-PGDH expression in human cholangiocarcinoma cells. Supplementary Figure S2. MiRNAs that target 15-PGDH 3-UTR. Supplementary Figure S3. TUNEL assay in CCLP1 cells with expression of Fat-1 and/or miR-26a. Supplementary Figure S4. Schematic presentation of pathways regulated by Ï‰-3 PUFAs in human cholangiocarcinoma cells.
Supplementary Table S1 from Stem Cell Transplantation Reverses Chemotherapy-Induced Cognitive Dysfunction
Authors: Acharya Munjal M. , Martirosian Vahan , Chmielewski Nicole N. , Hanna Nevine , Tran Katherine K. , Liao Alicia C. , Christie Lori-Ann , Parihar Vipan K. , Limoli Charles L.
Published: April 2023

Discrimination Indices.
Supplementary Figure Legends from p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and Carcinogenesis
Authors: Ehedego Haksier , Boekschoten Mark V. , Hu Wei , Doler Carina , Haybaeck Johannes , Gaβler Nikolaus , Müller Michael , Liedtke Christian , Trautwein Christian
Published: April 2023

Legend for Supplementary Figures S1-S8.
Supplementary Figure S2 from High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21–Mediated Matrix Metalloproteinase Activity
Authors: Chen Man , Liu Yao , Varley Patrick , Chang Ying , He Xing-xing , Huang Hai , Tang Daolin , Lotze Michael T. , Lin Jusheng , Tsung Allan
Published: April 2023

Supplementary Figure S2. MiR-21 inhibits HMGB1-dependent invasion and migration in vitro.
Supplementary Figure Legends from High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21–Mediated Matrix Metalloproteinase Activity
Authors: Chen Man , Liu Yao , Varley Patrick , Chang Ying , He Xing-xing , Huang Hai , Tang Daolin , Lotze Michael T. , Lin Jusheng , Tsung Allan
Published: April 2023

Legend for Supplementary Figures S1-S4.
Supplementary Methods, Figure Legends from TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression
Authors: Li Shinan , Sun Rui , Chen Yongyan , Wei Haiming , Tian Zhigang
Published: April 2023

Supplemental Materials and Methods and Figure Legends
Supplementary Figure Legend from CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ
Authors: Yan Hangyi H. , Jiang Jian , Pang Yanli , Achyut B.R. , Lizardo Michael , Liang Xinhua , Hunter Kent , Khanna Chand , Hollander Christine , Yang Li
Published: April 2023

Legend for Supplementary Figures S1-S6.
Supplementary Figure 3 from Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells
Authors: Jang Gyu-Beom , Hong In-Sun , Kim Ran-Ju , Lee Su-Youn , Park Se-Jin , Lee Eun-Sook , Park Jung Hyuck , Yun Chi-Ho , Chung Jae-Uk , Lee Kyoung-June , Lee Hwa-Yong , Nam Jeong-Seok
Published: April 2023

Characterization of primary human breast cancer cells.
Table S1 from Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis
Authors: Wu Min-Zu , Chen Su-Feng , Nieh Shin , Benner Christopher , Ger Luo-Ping , Jan Chia-Ing , Ma Li , Chen Chien-Hung , Hishida Tomoaki , Chang Hong-Tai , Lin Yaoh-Shiang , Montserrat Nuria , Gascon Pedro , Sancho-Martinez Ignacio , Izpisua Belmonte Juan Carlos
Published: April 2023

Table S1: Correlation of 5hmC, TET1 and TET3 with tumor hypoxia in 165 breast cancer cases.
Supplementary Figure 12 from Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells
Authors: Jang Gyu-Beom , Hong In-Sun , Kim Ran-Ju , Lee Su-Youn , Park Se-Jin , Lee Eun-Sook , Park Jung Hyuck , Yun Chi-Ho , Chung Jae-Uk , Lee Kyoung-June , Lee Hwa-Yong , Nam Jeong-Seok
Published: April 2023

Knockdown efficiency of shRNAs targeting IGF-I.
Supplementary Figures 1 - 10, Tables 1 - 3 from β-Arrestin-1 Mediates Nicotine-Induced Metastasis through E2F1 Target Genes That Modulate Epithelial–Mesenchymal Transition
Authors: Pillai Smitha , Trevino Jose , Rawal Bhupendra , Singh Sandeep , Kovacs Michelle , Li Xueli , Schell Michael , Haura Eric , Bepler Gerold , Chellappan Srikumar
Published: April 2023

Supplementary Figure S1. β-arrestin-1 depletion by siRNAs and shRNAs. Supplementary Figure S2. β-arrestin-1 is necessary for nicotine induced downregulation of E-cadherin and migration. Supplementary Figure S3. β-arrestin-2 is not required for nicotine induced invasion and expression of mesenchymal markers. Supplementary Figure S4. Fibronectin and vimentin promoters are E2F1 and Rb responsive. Supplementary Figure S5. Fine mapping of E2F1 responsive region in vimentin and fibronectin promoters. Supplementary Figure S6. β-arrestin-1 is recruited on vimentin and fibronectin promoters in response to nicotine stimulation. Supplementary Figure S7. E2F1, Rb, β-arrestin-1, p300, and Ac-H3 are not recruited on c-Fos promoter. Supplementary Figure S8. Levels of β-arrestin-1 after transfecting cells with β- arrestin-1 expression constructs. Supplementary Figure S9. β-arrestin-1 mediates the induction of EMT promoting transcription factors ZEB1 and ZEB2. Supplementary Figure S10. Nicotine induces β-arrestin-1 recruitment to ZEB1 and ZEB2 promoters. Supplementary Table 1: Position of putative E2F binding sites in fibronectin, vimentin, ZEB1 and ZEB2 promoters (1Kb upstream of transcription start site) as revealed by promoter analysis using Genomatix MatInspector program. Supplementary Table 2: Partial list of promoter regions where β-arrestin-1 is recruited upon nicotine stimulation as revealed by ChIP-sequencing. Supplementary Table 3: Pearson's correlation coefficient (r) showing correlation of vimentin, fibronectin and β-arrestin-1 expression from 116 NSCLC samples. β-arrestin-1 expression showed a very strong positive correlation with vimentin (r=0.59, p<0.0001) and fibronectin (r=0.52; p<0.0001).
Supplementary Methods and References from Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells
Authors: Bodogai Monica , Moritoh Kanako , Lee-Chang Catalina , Hollander Christine M. , Sherman-Baust Cheryl A. , Wersto Robert P. , Araki Yoshihiko , Miyoshi Ichiro , Yang Li , Trinchieri Giorgio , Biragyn Arya
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Table S1 from Agr2 Mediates Paracrine Effects on Stromal Fibroblasts That Promote Invasion by Gastric Signet-Ring Carcinoma Cells
Authors: Tsuji Tadahiro , Satoyoshi Rika , Aiba Namiko , Kubo Takanori , Yanagihara Kazuyoshi , Maeda Daichi , Goto Akiteru , Ishikawa Kazuo , Yashiro Masakazu , Tanaka Masamitsu
Published: April 2023

Supplemental Table S1. Correlation between expression and clinicopathologic features in patients with SRCC
Supplementary Figure S1 from Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells
Authors: Bodogai Monica , Moritoh Kanako , Lee-Chang Catalina , Hollander Christine M. , Sherman-Baust Cheryl A. , Wersto Robert P. , Araki Yoshihiko , Miyoshi Ichiro , Yang Li , Trinchieri Giorgio , Biragyn Arya
Published: April 2023

Despite being comparably expanded in response to 4T1 cancer, MDSC from Î¼MT mice are functionally impaired.
Appendix of names and affiliations of key speakers from The Inescapable Influence of Noncoding RNAs in Cancer
Authors: Adams Brian D. , Anastasiadou Eleni , Esteller Manel , He Lin , Slack Frank J.
Published: April 2023

Appendix of names and affiliations of key speakers
Supplementary Figure Legend, Methods and Materials, Tables 1-2. from Single-Strand DNA-Binding Protein SSB1 Facilitates TERT Recruitment to Telomeres and Maintains Telomere G-Overhangs
Authors: Pandita Raj K. , Chow Tracy T. , Udayakumar Durga , Bain Amanda L. , Cubeddu Liza , Hunt Clayton R. , Shi Wei , Horikoshi Nobuo , Zhao Yong , Wright Woodring E. , Khanna Kum Kum , Shay Jerry W. , Pandita Tej K.
Published: April 2023

Supplementary Figure Legend, Methods and Materials, Tables 1-2. Supplementary Table 1. Phase distribution in cells after enrichment by synchronization. Supplementary Table 2. Effect of Ssb1 depletion on spontaneous chromosome aberration frequency.
Supplementary Table S1 from Epigenetic Silencing of miR-490-3p Reactivates the Chromatin Remodeler SMARCD1 to Promote Helicobacter pylori–Induced Gastric Carcinogenesis
Authors: Shen Jing , Xiao Zhangang , Wu William K.K. , Wang Maggie H. , To Ka F. , Chen Yangchao , Yang Weiqin , Li May S.M. , Shin Vivian Y. , Tong Joanna H. , Kang Wei , Zhang Lin , Li Minxing , Wang Lin , Lu Lan , Chan Ruby L.Y. , Wong Sunny H. , Yu Jun , Chan Matthew T.V. , Chan Francis K.L. , Sung Joseph J.Y. , Cheng Alfred S.L. , Cho Chi H.
Published: April 2023

Supplementary Table S1: Absolute expression levels of miR-490-3p, miR-375 and let-7b in non-cancerous gastric mucosa.
Supplementary Figure S1 from Epigenetic Silencing of miR-490-3p Reactivates the Chromatin Remodeler SMARCD1 to Promote Helicobacter pylori–Induced Gastric Carcinogenesis
Authors: Shen Jing , Xiao Zhangang , Wu William K.K. , Wang Maggie H. , To Ka F. , Chen Yangchao , Yang Weiqin , Li May S.M. , Shin Vivian Y. , Tong Joanna H. , Kang Wei , Zhang Lin , Li Minxing , Wang Lin , Lu Lan , Chan Ruby L.Y. , Wong Sunny H. , Yu Jun , Chan Matthew T.V. , Chan Francis K.L. , Sung Joseph J.Y. , Cheng Alfred S.L. , Cho Chi H.
Published: April 2023

Supplementary Figure S1: No effect of miR-490-3p on necrosis and apoptosis.
Supplementary Figure 7 from Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression
Authors: Anz David , Rapp Moritz , Eiber Stephan , Koelzer Viktor H. , Thaler Raffael , Haubner Sascha , Knott Max , Nagel Sarah , Golic Michaela , Wiedemann Gabriela M. , Bauernfeind Franz , Wurzenberger Cornelia , Hornung Veit , Scholz Christoph , Mayr Doris , Rothenfusser Simon , Endres Stefan , Bourquin Carole
Published: April 2023

Supplementary Figure 7-Efficacy of anti-tumor treatment with CpG is dependent on an CD8+ T cell response.
Supplementary Figure legends from Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development
Authors: Wang Jian , Cao Ziquan , Zhang Xing-Mei , Nakamura Masaki , Sun Meili , Hartman Johan , Harris Robert A. , Sun Yuping , Cao Yihai
Published: April 2023

Supplementary Figure legends
SMovie S5 from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: April 2023

SMovie S5. N13R microglial cells are unable to migrate in response to wounding.
SMovie S4 from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: April 2023

SMovie S4. Migration of wt N13 microglial cells from both sides of a wounded monolayer after scratching with a plastic pipette tip.
Supplementary Figure S5 from miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
Authors: Shi Xu-Bao , Ma Ai-Hong , Xue Lingru , Li Meimei , Nguyen Hao G. , Yang Joy C. , Tepper Clifford G. , Gandour-Edwards Regina , Evans Christopher P. , Kung Hsing-Jien , deVere White Ralph W.
Published: April 2023

Immunostaining of AR-V7 in CWR22 xenografts.
Supplemental Figure S7 from Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
Authors: Crompton Joseph G. , Sukumar Madhusudhanan , Roychoudhuri Rahul , Clever David , Gros Alena , Eil Robert L. , Tran Eric , Hanada Ken-ichi , Yu Zhiya , Palmer Douglas C. , Kerkar Sid P. , Michalek Ryan D. , Upham Trevor , Leonardi Anthony , Acquavella Nicolas , Wang Ena , Marincola Francesco M. , Gattinoni Luca , Muranski Pawel , Sundrud Mark S. , Klebanoff Christopher A. , Rosenberg Steven A. , Fearon Douglas T. , Restifo Nicholas P.
Published: April 2023

Supplemental Figure S7. Pharmacologic inhibition of Akt modulates global metabolic profile and key lipid metabolites of antigen-experienced murine CD8+ T cells.
Supplementary Figures S1-S8 from Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer
Authors: Albino Domenico , Civenni Gianluca , Dallavalle Cecilia , Roos Martina , Jahns Hartmut , Curti Laura , Rossi Simona , Pinton Sandra , D'Ambrosio Gioacchino , Sessa Fausto , Hall Jonathan , Catapano Carlo V. , Carbone Giuseppina M.
Published: April 2023

Knockdown of ESE3/EHF and let-7 miRNAs in immortalized human prostate epithelial cells (S1); Lin28 protein expression in xenografts of human prostate cancer cell lines (S2); Ablation and forced expression of Lin28A and Lin28B affect the phenotype of normal and prostate cancer cells (S3); Consequences of miR-let7b expression in prostate cancer cells (S4); Predicted ETS binding sites (EBS) in the promoters of five let-7 family members (S5); ESE3/EHF rescues the effects of forced expression of Lin28A on the CSC compartment in normal prostate epithelial cells (S6); Lin28A and Lin28B downregulation affect the phenotype of human prostate cancer cells (S7); Efficiency of Lin28B downregulation by the Lin28B-2 siRNA in DU145 cells (S8).
Supplementary Table 2 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: April 2023

PI3Kβi (rac-KIN-193) treatment induces the interaction of p85 with a panel of proteins in PTENLOF/BRAFMUT melanoma. RVH-421 were treated with DMSO or 1μM PI3Kβi for 2h. Lysates were subjected to immunoprecipitation using an antibody targeting p85. Proteins in the range of 75 to 250 kDa were identified by LC-MS as described. Total spectra counts were used as a measure for protein quantity. The table summarizes the proteins enriched upon PI3Kβi treatment in the p85 precipitate. A spectral count ratio of 4 (log2 (PI3Kβi /DMSO) > 2) was taken as an arbitrary cutoff for significant enrichment.
Supplementary Table 1 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: April 2023

Supplementary information on the selectivity analysis shown in Figure 1A. (A) Representation of classes for all compounds used for the selectivity analysis. (B) Information on all significant hits showing selectivity for PTENLOF cell lines. The table summarizes the main target of the individual compound, the p value indicative of significant selectivity for sensitivity in the PTENLOF compared to the PTENWT cell line panel and the corresponding false discovery rate (FDR), the mean area over the curve (AOC) of the PTENLOF and PTENWT cell line panel, the total number of tested compounds with the same MoA and the rank of these additional compounds.
Supplementary Table 2 from Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival
Authors: den Hollander Petra , Rawls Kathryn , Tsimelzon Anna , Shepherd Jonathan , Mazumdar Abhijit , Hill Jamal , Fuqua Suzanne A.W. , Chang Jenny C. , Osborne C. Kent , Hilsenbeck Susan G. , Mills Gordon B. , Brown Powel H.
Published: April 2023

Supp Tab 2 - Cox proportional hazard ratio analysis of the Curtis Data set.
Supplementary Figure 1 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: April 2023

A) PTENLOF/BRAFMUT melanoma lines were treated with serial dilutions of the indicated drugs and their effect on phosphorylated and total Akt was evaluated by RPPA. B) PTENLOF calls in CCLE translate into absence of PTEN protein as evaluated by immunoblotting in a panel of BRAFMUT melanoma lines using antibodies targeting the amino- and carboxy-terminus of PTEN. PI3Kβi1/2=rac-KIN-193/TGX221, panPI3Ki=GDC0941, PI3Kαi=BYL719
Supplementary Figure Legends from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: April 2023

Supplementary Figure Legends
Supplementary Figure Legends from A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells
Authors: Hölzel Michael , Landsberg Jennifer , Glodde Nicole , Bald Tobias , Rogava Meri , Riesenberg Stefanie , Becker Albert , Jönsson Göran , Tüting Thomas
Published: April 2023

Supplementary Figure Legends
Suppl Table 2 from A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells
Authors: Hölzel Michael , Landsberg Jennifer , Glodde Nicole , Bald Tobias , Rogava Meri , Riesenberg Stefanie , Becker Albert , Jönsson Göran , Tüting Thomas
Published: April 2023

Supplementary Table 2. Gene lists of the human gene signatures used in this study.