bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Mentorship on Performance of Mission Hospitals in Kenya
Authors: Awino Peter , Juma Dennis , Eshiteti Stephen
Published: March 2024

Purpose: Those who employ creative leadership tend to do so by creating conditions which promote creativity. Creating such conditions are described as psychological, material, and/or social supports that trigger, enable, and sustain creative thinking in others. The study sought to establish the effect of mentorship creative leadership practice on performance of mission hospitals in Kenya and to establish the moderating effect of perceived organizational support on the effect of mentorship creative leadership practice on performance of mission hospitals in Kenya.

Methodology: The study was grounded on servant leadership theory and Transactional Leadership Theory. The cross-sectional survey design was used as the study design with the positivist philosophy also being adopted. The sample populations comprised 285 Mission hospital staff at middle or lower levels of employment selected through census. Questionnaire was the main data collection instruments. This was tested for validity and reliability before being used for the study. Collected data was analyzed quantitatively using SPSS 24th version software and was presented in the form of descriptive and inferential results. Descriptive statistics involved percentages, means and means of Standard deviations while inferential involved linear regression analysis. The study results were presented through use of tables and figures

Findings: The findings of the study underscore the substantial influence of effective mentorship in enhancing both individual and organizational performance in the context of Mission hospitals in Kenya. The strong agreement among respondents on the various aspects of mentorship, combined with the significant statistical correlation between mentorship and improved hospital performance, underscores the value of investing in robust mentorship programs. Perceived organizational support moderates the effect of mentorship on performance of Mission hospitals in Kenya.

Unique Contribution to Theory, Practice and Policy: The study recommends that healthcare institutions prioritize the development and enhancement of mentorship programs. These programs should focus on leadership development, skill acquisition, and professional growth, tailored to the diverse needs of individual employees. From the study, Mentorship could explain upto 63.1% of the performance of mission hospitals in Kenya. This study therefore recommends further study on other factors affecting performance of mission hospitals in Kenya.
Supervised Fusion Music Composition Through Long Short-Term Memory and Stochastic Modelling
Authors: Lee Matthew
Published: March 2024

Music composition has witnessed significant advancements with the infusion of artificial intelligence, particularly using Long Short-Term Memory (LSTM) networks. However, most existing algorithms offer minimal control to composers in influencing the genre fusion process, thereby potentially undermining their creative preferences. This study introduces a novel, two-phase algorithm for personalized fusion music generation that reflects the composer's individual preferences. In the first phase, melodies are generated for individual genres using Recurrent Neural Networks (RNNs) employing techniques like Sequential, Dense, and one-hot encoding. These generated melodies serve as input for the second phase, where an LSTM network fuses them into a coherent composition. Notably, the algorithm incorporates weights set by the composer for each genre, allowing for a personalized composition. A stochastic approach is employed in both phases to introduce creative variance while balancing structural coherence. We demonstrate this balance through various metrics offering a more tailored fused music generation experience enriched by stochastic modeling.
Assessing the Comparative Spatial Variances in the Effects of Urban Built Environments, City Risking Behaviors, and Air Pollutants on Breast and Prostate Cancer
Authors: Park Junseo , Kim Ho-cheol
Published: March 2024

Cancer is a serious public health dilemma. According to the World Health Organization (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. Therefore, research on effectively preventing and managing cancer is continuously needed in various fields in order to improve people's quality of life and safety. This study aims to explore the spatial distribution of incidences of breast cancer and prostate cancer that occurred in Korea from 2009 to 2013 with the use of the Geographic Information System (GIS). This research also examined the association between prostate cancer, breast cancer, air pollutants (CO, NO2, PM10, SO2), urban health-risk behaviors (smoking, drinking, and obesity), and the built environment of industrial, commercial, residential, and green areas. The main results showed that cancer incidence rates were highly clustered in specific regions and the regional differences in cancer incidence rates significantly depended on the cancer type. Concentrations of air pollutants also vary by region and tend to be high in certain regions. Air pollution is likely to play a mediating role in the relationship between the built environment and cancer incidences rather than the built environment directly affecting cancer incidences. These findings suggest that it is necessary to examine spatial and regional characteristics in building cancer prevention strategies and policies. This also emphasizes the need for interdisciplinary research for cancer prevention, not only in the medical field, but also in public health, urban planning, and environmental fields.
Climate Yield Models for Some Arable Crops in Ondo State.
Authors: Omotayo F. S. , Lasisi M. O , Ogundare S. A
Published: March 2024

This study looks at the connection between easily observed climate variables and crop production. Selected arable crops’ yield statistics spanning ten years were analyzed, including melon, rice, cassava, yam, and maize. Using multiple linear regression models calibrated for each of the selected crops, the crop yield was the dependent variable in SPSS statistical package version 22.0. The meteorological data, including mean temperature (oC), rainfall (mm), evaporation (mm/yr), and relative humidity (%), were correlated with the crop yield. Standard error of estimates (SE), coefficient of determination (R2), and correlation coefficient (R) are the goodness-of-fit parameters that are used to validate the models. The results demonstrated that the R-value for maize is 0.83 with a SE of 4.4 tons/ha, and the R-value for cassava is 0.85 with a SE of 10.2 tons/ha. R-values for yam and melon are 0.77 and 44.5 tons/ha, respectively; for rice and cocoyam, the values were 0.64 and 16.6 tons/ha, respectively. Melon has an R-value of 0.69 and 18.6 tons/ha. Factors such as crop management methods, diseases, nutrients, and other factors that are challenging to account for in the current statistical modeling approach could be the cause of the difference in the goodness-of-fit. There is a great need for efforts to produce trustworthy data for agricultural productivity forecasting and planning in the study region as well as all over the nation.
Cirugía de epilepsia lesional en pacientes adultos
Authors: Suárez Julio César , Palacios Claudio , Herrera Enrique J. , Nieto Flavia , Pueryrredon Francisco J. , Surur Alberto , Theaux Ricardo , Suárez María S. , Ryan Juan M. , Viano Juan C.
Published: March 2024

Objetivo: Presentar nuestra experiencia de 20 años en cirugía de epilepsia lesional en adultos.Población y métodos: Se llevó a cabo un estudio retrospectivo basado en historias clínicas de pacientes con epilepsia intervenidos quirúrgicamente entre enero de 1990 y diciembre de 2009 en el Sanatorio Allende.Resultados: En esta serie de 25 pacientes adultos fueron incluidos como causas: 12 tumores, 5 gliosis témporo-mesial, 5 cavernomas, 2 gliosis témporo-lateral y 1 displasia cortical. La localización fue temporal en 12 casos (48%) y extratemporal en 13 casos (52%). Entre el inicio de las crisis y la cirugía hubo en promedio 9,88 años. No hubo mortalidad quirúrgica; solo falleció un paciente por recidiva y malignización de un oligoastrocitoma, a los 12 años de la primera cirugía. El tratamiento resultó satisfactorio en base al control de las crisis convulsivas. Actualmente los 24 pacientes que viven se encuentran libres de crisis convulsivas discapacitantes.Conclusión: En nuestra serie los pacientes presentaron un buen control de las convulsiones luego de la resección de la lesión. De los 14 enfermos con epilepsia refractaria, 11 presentan un Engel IA, 1 un Engel IB y 2 un Engel ID.
Relato Oficial del 15th World Congress on Pain
Authors: Cerveró Fernando
Published: March 2024

Relato Oficial del 15th World Congress on Pain
Comprehending Qualifying Payment Amount (QPA) and the No Surprise Act in Healthcare
Authors: Koranchirath Nithin Narayan
Published: March 2024

Purpose: This article investigates the No Surprise Act, a pivotal piece of legislation designed to protect consumers from unexpected out-of-network healthcare charges, emphasizing the Qualifying Payment Amount (QPA) mechanism.

Methodology: Through a comprehensive literature review, analysis of legislative texts, and examination of case studies, this study elucidates the Act's origins, objectives, and operational framework of the QPA. It also explores the challenges of implementing the Act, its impact on various stakeholders (patients, healthcare providers, and insurers), and the broader implications for the U.S. healthcare system. Despite its intentions to curb surprise billing practices, the No Surprise Act and its QPA component face several implementation challenges, including administrative burdens, disputes over payment calculations, and unintended consequences on insurance premiums and healthcare market dynamics. This article leverages recent data, expert opinions, and comparative analysis with other healthcare models to provide a nuanced evaluation of the Act's effectiveness and areas for improvement.

Findings: The findings suggest that while the No Surprise Act represents a significant step forward in patient financial protection, ongoing adjustments and policy refinements are essential for achieving its intended outcomes without compromising the sustainability of healthcare providers and insurers.

Unique Contributor to Theory, Policy and Practice: Study and policy recommendations aims to contribute to the ongoing dialogue and efforts to enhance patient protection and healthcare affordability in the U.S., ensuring that the No Surprise Act lives up to its promise and potential..
Tecnologias digitais como mediação para o processo de alfabetização inclusiva de uma criança com TEA
Authors: Mello Tatiana de Souza , Barbosa Débora Nice Ferrari , Heidrich Regina de Oliveira
Published: March 2024

O artigo apresenta a análise de práticas educativas voltadas à alfabetização em uma criança com Transtorno do Espectro Autista a partir da mediação das tecnologias digitais em espaços de aprendizagem escolar. Além disso, o estudo também analisa estratégias que favoreceram o desenvolvimento de dinâmicas interdisciplinares. A pesquisa foi realizada em uma Escola Municipal de Educação Básica, localizada na região do Vale do Rio dos Sinos - RS. A estrutura metodológica é constituída pela abordagem qualitativa, de natureza aplicada e com objetivos exploratórios, utilizando o método da pesquisa-ação no campo de pesquisa e a investigação dos dados coletados através da análise de conteúdo de Bardin (2016). A prática apresentada é contextualizada a partir da perspectiva da Espiral da Aprendizagem Criativa, por meio de práticas interdisciplinares e colaborativas entre a turma da criança alvo do estudo e um Núcleo de Apoio Pedagógico. Como resultado, constataram-se progressos nos processos de alfabetização de todos os estudantes, incluindo a estudante com Transtorno do Espectro Autista, assim como, a potencialização das habilidades, fomentando a circulação de saberes entre as crianças e professores, por meio de ações interdisciplinares.
FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF TASTE MASKING MOUTH DISSOLVING TABLET OF LEVOCETIRIZINE DIHYDROCHLORIDE
Authors: Agarwal Shivendra , Misra Raghvendra , Gautam Girendra Kumar
Published: March 2024

Levocetirizine dihydrochloride is a selective, long acting peripheral  H1receptor antagonist. Allergic rhinitis is a symptomatic disorder of the  nose induced by inflammation mediated by immunoglobulin E (IgE) in the  membrane lining the nose after allergen exposure. Thus formulating  Levocetirizine into an mouth dissolving tablet dosage form would provide  fast relief. The Levocetirizine is bitter in taste so the Kyron T-114 (ion  exchange resin) was used to mask the taste and to formulate an mouth  dissolving tablet dosage form using drug resin complex. The tablets were  evaluated for the drug content, weight variation, water absorption ratio,  wetting time, in vitro disintegration, dispersion time, hardness, friability,  thickness uniformity. The tablets disintegrated in vitro within 22 to 66  seconds complete drug were released from tablet within 10 minutes.
An overview of Quinazolines: Applicability of molecular docking in Cancer therapy
Authors: Yadav Manoj Kumar , Prasad Triloki , Rathi Rubal , Kushwaha Vivek Kumar , Kumar Vinay , Yadav Sachin Kumar , Kumar Deepak , Rai Satyam
Published: March 2024

Medicinal chemistry is distracted with the elaboration, discovery,  confirmation of physical and chemical approaches, and the synthesis in  laboratory. Quinazoline derivatives occupy crucial positions in modern  medicinal chemistry and possess established application as medicine.  Several researches have been accomplished on derivatives of the  quinazoline for different many pharmacological activity are reported  recently. The most important process molecular docking modification is the  preliminary step in the drug designing of novel drugs. The main aim of this  review is to quiz or examine recently molecular docking strategies used in  medicinal chemistry and in the drug discovery, Investigating the  advancement in the field of computer aided drug design, and important role  play through the ligand-based method. The drug discovery and the field of  CADD is fast flourishing area that has seen various successes. Several giant  pharmaceutical industries, in additionally to academia, adopt computer aided drug design and discovery for drug lead discovery.
Quality By Design: Concept and Applications
Authors: Raikwar Ankita
Published: March 2024

Quality by design it is an approach in order to achieve quality of product in  terms of customer satisfaction for pharmaceuticals. By this review we just  summarised concept of quality, which is basically concerned with  reliability, timely performance and economic of product. According to Sir  Joseph Moses Juran “Quality could be planned and most quality associated  problems have their origin in the way in which quality was planned in first  place. It is based on ICH guidelines Q8 for pharmaceutical development,  Q9 for quality risk management,Q10 for pharmaceutical quality system. It  also compares between product quality by end product testing and by  quality design. USFDA has consistently working on this matter in order to  implement them on pharmaceutical industry. QbD advantages involves  robustness of process, successful completion, scope for invention,  enhanced understanding of method besides advantages, several  disadvantages associated are internal unwillingness of industries, lack of  belief in business core more time to file for generic products lack of  technology to implemen
A Review on Personalized Medicine: A Medical Treatment to The Individual Characteristics of Each Patient
Authors: Asif Mohammad , Pandey Anshuman , Khan Farheen Sanad , Rai Ayushi , Saqib Najmus , Alam Mr Qumre
Published: March 2024

The idea of Personalized Medicine is not new – Doctors have long  recognized that different patients react differently to medical  interventions because the goal of medicine has always been to treat  each patient as an individual. What is new is that paradigmatic  advances in science and technology hold out from hope for the  creation of targeted therapeutics and tools for determining who will  benefit from a medical treatment and who will have negative side  effects. Personalized Medicine has made significant advancements in  recent years, demonstrating the capability of science to radically  advance medical practice. Despite this, the problems of  understanding human health and disease remain sobering. The  intricate interplay of environmental, genetic, social, and cultural  factors affects not just “Who We Are…” but also “What Disease We  Are Prone To..” Fundamental advancements in our comprehension  of each of these characteristics, as well as how they interact, will be  necessary to realize a genuinely individualized approach to patient care. Personalized Medicine is something that concerns us all. Our  unique viewpoints have an impact on how we interpret this area’s  evolution. This section explains the idea of Personalized Medicine as  well as various modern definitions and uses of the term
Nano Technology- A Comprehensive Review
Authors: Bharatia Rakesh , Kumar Sanjay , Yadav Vikas
Published: March 2024

At the intersection of physical sciences, molecular engineering,  biology, biotechnology, and medicine, recent research on nanoscale  biosystems and nanotechnology has generated one of the most active  science and technology sectors. Improved comprehension of living  and thinking systems, ground-breaking biotechnology techniques,  the creation of novel medications and their targeted administration,  regenerative medicine, neuromorphic engineering, and the creation  of a sustainable environment are all included in this field. Research  on nano bio-systems is a top priority in many nations, and its  importance to nanotechnology is predicted to rise in the coming  years. The bioavailability of drugs is improved when their particle  sizes are decreased to the sub-micron range since this increases the  pace at which they dissolve significantly. The development of medication delivery employing nanoparticles  (NPs) as carriers for tiny and big compounds has generated a lot of  research attention. One of the most significant features of a  medication delivery system is the ability to direct drug administration  to sick areas. They have been utilized in-vivo to safeguard the drug  entity in systemic circulation, limit drug access to the targeted  locations, and deliver the drug to this site of action at a steady and  controlled pace. For drug delivery studies, a variety of polymers have  been employed to create nanoparticles that will boost therapeutic  value while reducing side effects. The most noteworthy  advancements in the use of nanotechnology as a medicine delivery  mechanism are highlighted in this review article. Systems,  techniques of preparation, applications, benefits, and drawbacks of  pharmaceutical nanotechnology.
Exploration of Isatin as Anti-cancer and Anti-tubercular Modern Armamentarium. A Comprehensive Review on Isatin Congeners and its Promising Biological Activities
Authors: Gour Vivek Kumar , Gour Sadhna , Choudhary Akram , Noman MD , Yar M Shahar , Vats Nisha , Yahya Shaikh
Published: March 2024

In recent eras, cancer, and tuberculosis have become the leading causes of  not only morbidity but also mortality. Around 10 million cancer-related  fatalities are reported annually worldwide, but 10.4 million new cases are  also discovered each year. According to World Health Organization data,  10.4 million cases were in 2016 worldwide, whereas 360,565 cases in  Indonesia was reported. Some clinically approved anticancer and anti-TB  drugs demonstrate a most promising role in their treatment. Still, the need  for new, powerful, and secure candidates as anticancer and Anti TB  agents with a variety of modes of action is constantly present due to the  serious growth of drug resistance, side effects, multidrug-resistant  malignancies, and tuberculosis as a result of mutations. Over the last  decade, various heterocyclic compounds in medicinal chemistry were  explored and reported frequently in the literature; these derivatives have  received substantial attention as anticancer and anti-TB agents. In which  nitrogen-containing heterocyclic moiety, isatin emerged as a significant  and versatile heterocyclic for developing novel anticancer and anti-TB  candidates.
Future of Pharmaceutical Marketing in India-An Extensive Review
Authors: Asif Mohammad , Alam Mahtab , Alam Qumre
Published: March 2024

Pharmaceutical marketing is becoming more and more personal as  businesses aim to adjust their goods and services to the specific  requirements of each patient. This personalization is made possible  by technological advancements, which make use of big data, artificial  intelligence, and machine learning. 
Pharmaceutical marketing is also changing as a result of  digitalization. To engage with clients, businesses are investing in  online platforms, social media, and mobile apps. The transition to  digital marketing is a result of customers' shifting habits, who are  increasingly looking online for healthcare information and guidance.  Another significant factor influencing the future of pharmaceutical  marketing is regulatory developments. Fresh legislation are being  passed by governments all over the world in order to protect patients  and guarantee the efficacy and safety of medications. This is- leading  to greater transparency and accountability in the industry, as well as  increased competition and innovation. Patient empowerment is also  a significant trend in pharmaceutical marketing, with patients  becoming more involved in their own healthcare decisions. This is  driven by a growing awareness of the importance of patient-centered  care, as well as the increasing availability of health information  online.
Polyherbal effervescent granules: An abeyant leap in the management of polycystic ovarian syndrome (PCOS)
Authors: Vohra Payaam , Rane Anurag , Khochare Sanika
Published: March 2024

Polycystic ovarian syndrome (PCOS) is a neuroendocrine metabolic  disorder characterized by an irregular menstrual cycle. In this current  cram, we discuss the significance of herbal remedies in the treatment  of PCOS, and the chemical composition, mechanism of action, and  therapeutic application of selected herbal drugs against PCOS.  Herbal drugs have a promising role in treatment and efficient  management of PCOS. We have reviewed various key medicinal  herbs and come up with a unique polyherbal formulation and its  specialized significance in PCOS management. This evaluation will  be of significant use to researchers working on herbal therapies to  treat PCOS. Complementary or alternative medicine, such as herbal  formulations containing herbal extracts of Turmeric, Aloe Vera,  mint, and fenugreek, have been highly regarded as natural sources  with low side effects and additional benefits of reducing  hyperandrogenism, insulin resistance, and ovarian weight. These  plant-based herbal formulations can be effective in this syndrome,  which affects serum levels of different hormones and ovarian  morphology, representing an opportunity to investigate and discover  new bioactive products. Some of the most effective herbs and their  formulations that play a critical role in the treatment of PCOS are  summarized in this article.
A Review Process of ANDA Filling in PMDA (Japan) and Calibration of UV in Accordance to its Regulatory Guidelines
Authors: Yadav Saurabh , Panda Subhranshu , Raikwar Ankita
Published: March 2024

The Abbreviated New Drug Application (ANDA)  filing system is an important regulatory process in Japan for the  approval of generic drugs. This system allows pharmaceutical  companies to submit an application for the marketing and sale of a  generic drug, which has already been approved by the regulatory  agency in another country. The ANDA system in Japan is similar to  that of the United States and Europe, but there are some unique  aspects that must be taken into account. For example, in Japan, the  regulatory agency requires a separate drug master file for each active  pharmaceutical ingredient, which can be a time-consuming process.  UV spectrophotometry is a widely used analytical technique for the  characterization of pharmaceuticals, including active  pharmaceutical ingredients and finished dosage forms. The  Shimadzu UV-1800 spectrophotometer is a popular instrument for  this purpose, which is widely used in Japan. This instrument has a  range of features that make it particularly useful for pharmaceutical  analysis, including a wavelength range of 190-1100 nm, a double beam optical system, and a low stray light level. The Shimadzu UV 1800 is also compatible with a range of accessories, such as a  multicell holder, which allows for the simultaneous measurement of  multiple samples.  The combination of the ANDA filing system and UV  spectrophotometry using the Shimadzu UV-1800 is an important tool  for the development and approval of generic drugs in Japan. The  ANDA system allows for a streamlined regulatory process for  generic drug approval, while UV spectrophotometry provides a reliable and accurate method  for the characterization of  pharmaceuticals. Together,  these tools help to ensure the  safety and efficacy of generic drugs in Japan.
A Review on Lactic Acidosis in Cardiac Surgery
Authors: Nithyakala P , Dharsshini N , Bharathi S Dhivya , Hamsavarthini S , Malini N  Indhu
Published: March 2024

The normal range of lactate is 0-2mmol/L and value  above it is considered as hyperlactatemia. It may arise due to  adequate and non-adequate oxygen supply mechanisms. The major  reason is likely stress–induced aerobic mechanism which shows  raised results of lactate. Increased lactate levels can cause acidifying  effects on the blood. There are many etiological reasons for lactic  acidosis like disease condition, deficiency and alcohol. Early and late  onset are two categorizations for patient with hyperlactatemia after  cardiac surgery. On being the major trigger factor for lactic acidosis  in cardiopulmonary surgery patients due to tissue hypoperfusion. So  preventive measures before cardiac surgery should be taken.
In-vitro Antidiabetic Activity of Acacia Arabica Leaves
Authors: Kumar Vineet , Saifi Tabassum , Shipra  , Kumar Anil , Singh Bhanoo Pratap
Published: March 2024

The aim of thpresent study was toinvestigate the phytochemicalbioactive compounds of the ethanolic extract of Acacia Arabicaleaves and its in-vitro anti-diabetic activity. The intestinal digestiveenzymes alpha-glucosidase and alpha-amylase play a very importantrole in the digestion of carbohydrates. One antidiabetic therapeuticapproach reduces the post-prandial glucose level in blood by theinhibition of alpha-glucosidase and alpha-amylase enzymes. Theseare important strategies in the management of bloodglucose. Theresults of this assay suggest that the presence of bioactive compoundscould be responsible for the versatilemedicinal properties of thiplant including diabetes, the extract exhibits a dose-dependentincrease in inhibitory effect on glucose diffusion (up to 72.03%), andalpha-amylase enzyme (up to 64.84%). The current in-vitro studyproves that the ethanolic extract of Acacia Arabica leaves has anti-diabetic activity.
An Overview on Sodium-Glucose Cotransporter 2 (SGLT-2) Inhibitors Induced Euglycemic Diabetic Ketoacidosis: Clinical Manifestation, Mechanism, Diagnosis, Prevention and Treatment
Authors: Aakash R , Prathap S Aswin , Raj S Deepak , Dharshne P T , Priyamalar E M Neena
Published: March 2024

Euglycemic diabetic ketoacidosis is a transient and  dangerous metabolic condition characterized by ketoacidosis and  considerably lower blood glucose levels which is associated with  the usage of newer class of oral antidiabetic medication known as  Sodium-glucose cotransporter 2 (SGLT-2) inhibitors. The primary  mechanism involved in SGLT2 inhibitors induced eDKA would  due to increased lipolysis and ketone body reabsorption. SGLT2i  also tend to increase the pancreatic alpha cells, which  simultaneously blocks the beta cells, thereby causing an disruption  in glucagon/insulin ratio that accounts to enhanced lipolysis and  ketogenesis, which is clinically manifested with Fatigueness,  stomach pain, nausea and vomiting resulting in reduced blood  pressure and dehydration, altered psychological condition, dyspnea,  rapid breathing, loss of appetite, pyrexia and tachycardia. Despite  lower blood glucose levels or the absence of urine ketones,  euglycemic DKA is difficult to diagnose and should be examined  in the differential diagnosis of an ill patient who as a previous  history of diabetes mellitus. eDKA is often triggered by insulin  absence or dose drop, severe acute sickness, dehydration, strenuous  activity, surgeries, low-carbohydrate meals, or heavy alcohol or  drug abuse. Making the definitive diagnosis using conventional  diagnostic tools and clinical standards, as well as coordinating fluid  resuscitation, insulin treatment, and electrolyte replacement based  on information gained from prompt patient observing and  knowledge of resolution criteria, are all components of  management and the prevention method includes patient and  physician education on risk and precipitating factors and  suspending SGLT2 inhibitors therapy may reduce SGLT2  inhibitor-induced eDKA, which are more critical. This review  briefly illustrates on the signs & symptoms, mechanism of  induction, investigation and diagnosis, prevention and treatment of SGLT2 inhibitors-induced Euglycemic diabetic ketoacidosis (eDKA)
Role of Artificial Intelligence in Health care System
Authors: Chauhan Dolly , Singh Rupam Kumar , Kaur Mandeep , Septa Archna , Jain Ashish
Published: March 2024

The Indian healthcare scenario presents a spectrum of  contrasting landscapes. In all, 400 million individuals had no access  to any form of basic healthcare while two billion people do not have  access to required medications. Therefore, more than one-fourth of  the world population has unmet health needs. This leaves the global  community with the challenge of how to support a significant  number of the world’s populace still lacking in access to basic  healthcare facilities. AI has been a disruptive healthcare innovation.  With its sophisticated algorithms and several applications, AI has  assisted doctors and medical professionals in the domains of health  information systems, geocoding health data, epidemic and  syndromic surveillance, predictive modelling and decision support,  and medical imaging. Artificial intelligence (AI) rapidly dominates  the health service system. It removes the manual health system into  automatic, in which humans conduct the routine works/tasks in  medical practice to the management of patients and medical  resources. Drug development is a famously costly procedure.  Machine Learning can improve the efficiency of many of the  analytical techniques used in drug development. In terms of  practical implications, this paper aims to create a fruitful discussion  with healthcare professionals and administrative staff and the role  of artificial intelligence in healthcare system. Furthermore, this  investigation offers a broad comprehension of bibliometric  variables of AI techniques in healthcare.
To Study the Prescription Pattern of Antihypertensive Drugs in Teerthanker Mahaveer Hospital Moradabad (U.P.)
Authors: Kumar Sharad , Bedi Ashish , Kumar Arun , Tomer Sheetal Singh
Published: March 2024

Objective of the study: To assess prescribing pattern of  antihypertensive drugs use and adherence to various clinical  guidelines in the Hospital. Materials and methods: A prospective  observational study was carried out for a period of six months in the  IPD and OPD tertiary care hospital. Prescriptions were analyzed  during the study period. All the patients of age ≥ 20 (20-70 age) years  with or without comorbidities, including males and females, who  were diagnosed with hypertension as per JNC 8, ESH/ESC, NICE,  STG, IHG, and receiving antihypertensive drugs were included.  Discussion: The results of our study suggested that out of the total  number of hypertensive patients (202) males were 54.45% witch  females were 45.55%. Therefore, there was immensely need of  proper awareness about the hypertension and its etiologies among the  population especially of younger generation. In this scenario, clinical  pharmacist could do a lot more for the patients and overall society  because of their expertise in Pharmaceutical Care. Conclusion:  Calcium channel blockers, Diuretics, ARB as monotherapy and ARB  with CCB as combination therapy were the choices for the treatment  of Hypertensive patients as a single drug and combination drug  therapy. As per the JNC 8 & ESC/ESH guidelines majority of the  prescription patterns were achieved and found optimal at the study  site.
To evaluate the anti-oxidant and anti-diabetic action of Dolichos Trilobus Linn. in Wistar albino rats
Authors: Saxena Ritik , Singh Monika , Kumar Arun , Barman Moumita
Published: March 2024

Aim: The chief motive for doing the research is to  estimate the therapeutic outcomes of aqueous extract of Dolichos  trilobus to respond diabetes induced by Streptozotocin. Materials &  methods: The primary focus is to calculate the therapeutic effects of  Dolichos trilobus given once orally to the two test groups. Thirty  Wistar Albino rats were equally circulated between five groups.  Study of Dolichos trilobus aqueous extract was carried out for 21  days. During this period twelve rats were divided to form two  different groups and were given a dose of“200 mg/kg/day, 400  mg/kg/day”. No mortality was seen at 400mg/kg even after  constantly dosing for next 21 days, considered it safe. Control group  was given distilled water on the dose of 10ml/kg/day orally.  Streptozotocin was given to both the Negative group as well as  Standard group on the dose of 60mg/kg/day via Intra-peritoneal  route. Glibenclamide has been set to the Standard group on the dose  of 10mg/kg/day orally. Aqueous extract of Dolichos trilobus (Sickle  Bean) was given to the Test-1 group on the dose of 200mg/kg/day  orally. Aqueous extract of Dolichos trilobus was given to the Test-2  group at a dose of 400mg/kg/day orally. Results: Streptozotocin  causes hypoinsulinemia and hyperglycemia due to production of  pancreatic islet β-cell destruction. The diabetes was confirmed by  increased level of glucose in blood, lipid per oxidation (MDA level),  reduction in GSH level, food intake, body weight and  histopathological variations were seen in negative group are  compared to control group. This evaluation has shown that there was  no major diversity in between Standard group and Test-3 (Aqueous  extract of Dolichos trilobus 200 mg/kg) group. It means Test-3 have  nearly same therapeutic efficacy as standard drug. Conclusion: The  conclusion of the research indicates that the aqueous extract for
Review on "Herbal Preparations from Ayurveda used to treat Rheumatoid Arthritis"
Authors: Bharatia Rakesh , Gupta Nidhi , Upadhyay Preeti , Kumar Shailendra
Published: March 2024

Ayurveda is a natural medicine system that originated in India  over 3,000 years ago. The name "Ayurveda" (science or knowledge) is  derived from the Sanskrit words Ayur (life) and Veda. Thus, the name  Ayurveda, which means "knowledge of life." The popularity of Ayurveda,  or traditional. Since most patients begin taking conventional medications  as soon as they are diagnosed, ayurvedic therapies are usually administered  in combination with or after orthodox medical techniques. To properly  grasp the potential effect of food, spices, and medicinal plants, one must  have a thorough understanding of their actions. Realizing the potential of  Ayurvedic medicine and philosophy and incorporating it into contemporary  medical practice is crucial. There are some significant differences between  the mechanisms of action of synthetic pharmaceuticals and single  constituents and those of polyherbal treatments and their extracts. Despite  being based on natural herbal elements, the safety of ayurvedic treatments  depends on how they are delivered, taking into account the needs of the  individual and their specific sickness circumstances. Many contemporary  drugs are derived from the botanicals used in Ayurveda and other  traditional medicinal systems. It is expected that a significant step toward  resolving some of the current challenges in treating complex disorders like  arthritis with only modern pharmaceuticals would be the confirmation of a  combined therapy strategy (Ayurveda and contemporary medicine) with  improved efficacy and safety.
A Systematic Review: Safety and Efficacy of Anticoagulation therapy for Atrial fibrillation and venous thromboembolism
Authors: Parveen Sadia , Vashist Ankit , Jain Neha , Singh Ravindra Pal , Chanana Arsh
Published: March 2024

For the prevention and treatment of thrombosis, anticoagulants  continue to be the principal approach. Since direct thrombin  inhibitors are usually saved for patients who need intervention or  who have complications, unfractionated heparin, low molecular  weight heparin, and warfarin have all been thoroughly studied and  used.As a result of their improved pharmacodynamic profiles and ease of  use, novel oral anticoagulants are predicted to supplant older ones  once they emerge from clinical development. Of all the side effects  of anticoagulants, bleeding is the most worrying. Anticoagulant  pharmacology, dosage, and toxicity are widely used, so clinicians  must be well-versed in these areas. 
 Traditionally, heparin was given to patients who needed  parenteral anticoagulation, while warfarin was given to patients who  needed oral anticoagulation. There has been a push to create newer,  more potent anticoagulants because of warfarin's limited therapeutic  index and the requirement for regular laboratory monitoring.
Utilizing Watermarking Technique for Detecting Data Leakage in Cloud Environment
Authors: Sibi Sharan S  , Haripriya V
Published: March 2024

Ensuring safety in dossier management is paramount due to the immense value of stored information. While hackers are often attributed to security breaches, the reality is that a significant portion of data loss stems from insiders. In traditional setups, the transfer of critical data from suppliers to trusted entities is a frequent occurrence. Preserving the security and integrity of these transactions is crucial to meeting the increasing demands of consumers. Any leakage of sensitive data exposes customers to potential risks from the outset. Therefore, establishing secure channels for data transfer between suppliers and recipients is imperative. This project proposes a solution for detecting data leaks using watermarking technology, which detects tampering attempts and identifies the source of leaked information. The system operates within a cloud environment, ensuring accessibility and scalability.
Therapeutic significance of aestheticisation of affect in the sychosomatics of personality development
Authors: Dobrowolski Robert , Salamon-Krakowska Katarzyna
Published: March 2024

Both in the physiotherapeutic practice and artistic activity-based therapy, apart from purely somatic disorders, we often encounter the impairment of mentalizing abilities. Patients cannot express their sensations, feelings, or affects. As evidenced by the psychoanalytical theory developed on the basis of a substantial clinical material, this can lead to psychosomatic disorders. Their treatment, involving activities and methods that help reinforce the patient’s ability to aesthetically experience their own psychophysicality as a harmoniously connected unity, turns out to be extremely useful. It is thanks to art and aesthetic experiences that we gain access to these aspects of our psychophysical condition, which are unaccounted by abstract analysis. Our aesthetic experience reveals mainly the unconscious and affective components of our life attitude. Moreover, these kinds of experiences allow us not only to recognize our psychosomatic conditions as well as problems that we experience, but also to effectively and somaesthetically work with them. The art-based therapy and artistic activities allow the harmonizing experience of unity of the emotional and physical with the intellectual and symbolic, and thus open up the opportunity to regain a deep sense of meaningfulness.
Effectiveness of individualized physical rehabilitation programs on post-mastectomy pain in breast cancer survivors
Authors: Odynets Tetiana , Briskin Yuriy , Sydorko Oleh , Tyshchenko Valeria , Putrov Sergiy
Published: March 2024

Introduction

The aim of the study was to determine the effectiveness of individualized physical rehabilitation programs targeted at reducing post-mastectomy pain in breast cancer survivors.

Methods

Overall, 115 women with post-mastectomy pain were enrolled. The subjects had undergone surgical treatment and adjuvant radiation therapy for breast cancer. They were randomly assigned for the first (group A, n = 45), second (group B, n = 40), and third individualized physical rehabilitation program (group C, n = 30). The first program included aqua aerobics (aqua jogging, aqua building, aqua stretching), conditional swimming, and recreational aerobics; the second program included conditional swimming and Pilates exercises; the third program included yoga-based exercises and stretching. All participants received 140 sessions of rehabilitation intervention during the year and were evaluated at the beginning of the study, at 6, and at 12 months.

Results

It was observed that most of the investigated pain characteristics in all studied groups steadily improved during the year of rehabilitation. After 6 months of rehabilitation, the average value of cognitive quality of pain was statistically higher in group C compared with group A by 0.43 points (p < 0.01).

Conclusions

The findings suggest that the first individualized physical rehabilitation program brought about the greatest pain reduction in the affected breast and upper extremity in breast cancer survivors of the studied groups.
Hubungan Sikap Sosial Terhadap Prestasi Belajar Siswa Pada Masa Pandemi Covid 19 Kelas VIII SMP Negeri 1 Perbaungan
Authors: Khairina Ulfa Syaimi Nur Asiyah Pohan,
Published: March 2024

Penelitian ini bertujuan untuk mengidentifikasi hubungan antara sikap sosial siswa terhadap prestasi belajar mereka pada masa pandemi COVID-19 di SMP Negeri 1 Perbaungan pada tahun ajaran 2020/2021. Identifikasi masalah dilakukan untuk memfokuskan penelitian dan menghindari kesimpangsiuran dan tumpang tindih dalam fokus penelitian. Masalah-masalah yang diidentifikasi adalah kurangnya diskusi siswa mengenai tugas, kurangnya empati siswa terhadap teman yang kesulitan memahami pelajaran, rasa bosan siswa karena pembelajaran jarak jauh, menurunnya semangat belajar, penurunan nilai siswa berdasarkan informasi guru, dan pembatasan hubungan sosial karena pembelajaran daring. Penelitian ini menggunakan desain penelitian korelasional dengan metode kuantitatif untuk mengkaji hubungan antara variabel sikap sosial dan prestasi belajar siswa. Populasi penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 1 Perbaungan Tahun Ajaran 2020-2021 yang berjumlah 100 orang siswa. Data diperoleh melalui angket berbentuk skala Likert yang digunakan untuk mengukur sikap sosial siswa. Angka koefisien korelasi -0,323 menunjukkan adanya hubungan yang signifikan antara sikap sosial dan prestasi belajar siswa. Artinya, semakin tinggi sikap sosial siswa, maka semakin rendah prestasi belajar, dan sebaliknya. Penelitian ini memberikan wawasan penting bagi dunia pendidikan. Guru dan pihak sekolah harus memperhatikan pentingnya pengembangan sikap sosial siswa untuk meningkatkan prestasi belajar mereka. Peningkatan sikap sosial dapat menciptakan lingkungan pembelajaran yang lebih kondusif dan memastikan keberhasilan siswa dalam proses pembelajaran. Meskipun demikian, perlu diingat bahwa masih banyak faktor lain yang mungkin mempengaruhi prestasi belajar siswa dan sikap sosial mereka yang perlu dipertimbangkan dalam penelitian lebih lanjut.
Perceptions of University Students Regarding the Implementation of Translation as a Teaching Strategy
Authors: Nhan Lam Ky
Published: March 2024

Translation has historically been a subject of debate in the field of English education. It has been widely disregarded as a legitimate endeavor for language practice and enhancement. Despite the opposition of many language educators, the prevailing view on the use of translation in language classrooms is gradually shifting. Increasingly, experts are recognizing the beneficial role that the first language plays in English Language Teaching (ELT). This topic has been deliberated in the context of language pedagogical techniques. The primary objective of this study was to examine the utilization of translation as a learning approach by Vietnamese English learners in their pursuit of acquiring proficiency in the English language. It is also important to identify the translation mechanisms that students employ during the learning process. To do this, the study utilized the quantitative approach, involving 120 Vietnamese university students who are learning English as a foreign language. Subsequent data analysis and statistical calculations demonstrated that language learners employed a diverse range of learning strategies pertaining to translation in order to comprehend, retain, and generate English, regardless of whether their teachers opposed such practices.
La nostalgia, el dolor y la esperanza de los emigrantes y retornantes metaforizada en los huaynos ayacuchanos
Authors: Crisóstomo Oré Hugo , Tenorio Velásquez Micaela , Gutiérrez Pizarro Nelly
Published: March 2024

Esta investigación explora la profunda conexión entre la nostalgia, el dolor y la esperanza de los emigrantes y retornantes, revelando cómo estos sentimientos se entrelazan y encuentran su voz en la música de Ayacucho. Se analizan las metáforas en los huaynos ayacuchanos para reflejar las experiencias emocionales y los desafíos socioculturales de estos grupos. El estudio profundiza en la rica tradición de los huaynos ayacuchanos para mostrar cómo estas canciones metaforizan y encapsulan los sentimientos de quienes han emigrado y regresado, añoran regresar, o incluso aquellos que han vuelto sin darse cuenta. A través del análisis de letras y narrativas, se arroja luz sobre emociones como la nostalgia, el dolor y la esperanza que rodean la emigración y el retorno, enriqueciendo nuestra comprensión de las experiencias humanas en el contexto global contemporáneo. Así también, busca responder a preguntas clave, como la manera en que los huaynos ayacuchanos muestran los sentimientos de nostalgia, dolor y esperanza en sus letras, y cómo estas expresiones metafóricas capturan las experiencias emocionales y socioculturales de los emigrantes y retornantes de Ayacucho. Los objetivos principales son examinar cómo estos huaynos plasman y combinan estos sentimientos, así como analizar las metáforas que reflejan desafíos y experiencias de estos grupos.
Pre-service Teachers’ Understanding of Graphs in Statistics in the Context of Lesson Study
Authors: Yılmaz Nadide , Yetkin İffet
Published: March 2024

This study aims to examine pre-service teachers’ understandings of graphs and how their understandings about graphs have transformed into instructional practices as they participated in a lesson study. It was employed case study and three pre-service teachers participated. They initially viewed graphs as tools for organizing and representing data. As the lesson study progressed, they began to view graphs as tools to answer statistical questions. This fundamental transformation in their understanding resulted in a change in how they designed and implemented their lesson plans. They designed tasks around a statistical question and made connections with this question while deciding the type of graph and interpreting the graph. In addition, they anticipated students’ possible conceptions. Hence, for these pre-service teachers, understanding the role graphs as tools to answer statistical questions can be considered as a key development understanding (KDU), which was built on multiple experiences of designing, implementing and evaluating lessons.