bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Penggunaan Media Buku Saku dan Metode Ceramah Sebagai Usaha Peningkatan Pengetahuan Ibu dalam Pencegahan Karies Gigi di Posyandu Kelurahan Andalas Kota Padang
Authors: Yase Havina , Ramayanti Sri , Nofika Reni
Published: December 2021

Dental caries is a common tooth problem found among children. Mother's knowledge is a factor that influences children's dental caries prevention. Various media and methods can increase knowledge, such as pocket book and lecture methods that contain material about prevention of children’s dental caries. The objective of the study is to determine the effect of using pocket book and lecture methods on mother’s knowledge about children’s dental caries in Andalas District, Padang. This study used a quasi-experimental method with a pretest-posttest design. The sample was divided into two groups with different treatment, 22 samples were given health education using pocket book and 22 samples were given health education with the lecture method. Data analysis included Wilcoxon test and Mann-Whitney test. The result of the study is there is a significant difference knowledge between before and after health education to samples used pocket book (p-value=0,01) and lecture method (p-value=0,01). There is no significant difference for both groups (p > 0.915). The conclution of the study is health education using pocket book and lecture methods can increase mother’s knowledge about children’s dental caries prevention.
Pengaruh Pengetahuan dan Sikap Ibu yang Bekerja Dari Rumah Selama Work Form Home Terhadap Perilaku Anak Dalam Menjaga Kebersihan Rongga Mulut dimasa Pandemi Covid-19
Authors: Sari Desy Purnama
Published: December 2021

The covid-19 pandemic is hitting the world including Indonesia. Work from home (WFH) is one of the Indonesian goverment's policy to prevent the spread of covid-19. The mothers knowledge, attitude, and practice regarding oral health are the important indicator that reflect their children's oral health behaviour. Objective:  to analyse the relationship of mother's knowledge and practice to the children's oral health behaviour during WFH in the covid-19 era. Method: This is a cross-sectional study used the purposive sampling techniques. Thirty respondents were selected by the following criterias: women; have children aged 12 months until 12 years; work outside the home as employees; and willing to participated in this study. Respondents were instructed to fill the self-administered questionnaire through the Google Form application. Data of the mother's knowledge, practice and the children's behaviour were collected, then analysed by computerizing system. Results: Good knowledge and positive practice about oral health was represented by each 73,3% respondents. Approximately 76,7% of the children had satisfaction behaviour and only 23,3% had unsatisfaction of oral health behaviour. The study shows a statistical significant relationship of mothers’ knowledge level (p=0,003) and mother's practices (p=0,044) to their children's behavior toward oral health care. Conclusion: There is a significant relationship between mother's knowledge and practices to the children's oral health behaviour. Good knowledge and positive attitude of mothers determined the satisfaction of children's behaviour in the oral health care, especially int the covid-19 era.
Hubungan Stres dengan Temporomandibular Disorder pada Mahasiswa Fakultas Kedokteran Gigi Universitas Andalas
Authors: Adani Zhafarina , Atika Atika , Pujiastuti Arymbi , Rahmi Eni
Published: December 2021

Stress is the body’s response to various stressors that demand individual adjustment. College students often experience stress during their studies. Excessive stress can interfere the normal function of the body that can trigger the onset of temporomandibular disorder. The study aims to determine the relationship between stress and temporomandibular disorder in Dental Students of Andalas University. This study was observational analytic with the cross sectional design. The respondent was selected through purposive sampling technique with the total respondent were 67 students. The responden’s stress was measured with Student Stress Inventory (SSI) questionnaire, while temporomandibular disorder was examined and determined by RDC/TMD Axis I. The results showed that 37 respondents (55,2%) had mild stress and 30 respondents (44,8%) had moderate stress. The prevalence of temporomandibular disorder was 61,2%. Disc displacement with reduction was the most dominant diagnosis of temporomandibular disorder. Statistical chi-square test results obtained p=0,019 (p<0,05) that meant there was a significant relationship between stress and temporomandibular disorder in Dental Students of Andalas University. The result of this study concluded that there was relationship between stress and temporomandibular disorder.
Perbandingan Efektifitas Susu Sapi Cair Kemasan dan Keju Cheddar Kemasan dalam Membantu Menaikkan pH Saliva
Authors: Nasri Haniyah Atsila , Lendrawati Lendrawati , Ristiono Bambang
Published: December 2021

Objective: Oral acidity level that can be assessed from salivary pH is one of indicator for oral health. Diet can change the pH level of saliva, in which low salivary pH caused demineralization of dental email. Milk and cheese have been proven to increase salivary pH because of anticariogenic activity due to the content of casein, calcium, and casein phosphopeptides. This study was aimed to compare the effectivity of packaged cow’s milk and packaged Cheddar cheese to increase salivary pH.; Method: This study was an experimental study with pretest-posttest design. Samples were 35 students in Dentistry of Andalas University, which corresponding to inclusion criteria consumed 125ml packaged cow’s milk and 17gr packaged cheddar cheese in 1 minute on two different days. Salivary pH was measured at time intervals of 5 minutes after consuming soft drink, 5, 10, 15, and 30 minutes after consuming packaged cow’s milk and packaged Cheddar cheese. The data was analyzed by using Wilcoxon and Mann-Whitney statistic test; Result: Wilcoxon test result showed no significant difference in packaged cow’s milk group (p>0,05), and there was a significant difference in packaged cheddar cheese group (p<0,05). Mann-Whitney test result showed a significant difference at 5 and 10 minutes posttest between two groups (p<0,05); Conclusion: There was significant difference in salivary pH between two groups. Packaged cheddar cheese showed significant difference in salivary pH after consumption than packaged cow’s milk.
Jamur Endofit Arthrinium sp., Sumber Potensial Senyawa Obat Review
Authors: Eltivitasari Andita , Wahyuono Subagus , Astuti Puji
Published: December 2021

Keberadaan jamur endofit di alam sangat melimpah dan mudah ditemukan pada jaringan tanaman antara lain pada akar, batang, daun, bunga atau biji. Endofit berkoloni di area antar dan intra-sel dari jaringan tanaman tanpa efek merugikan pada tanaman tersebut. Jamur endofit mempunyai kemampuan memproduksi senyawa bioaktif yang dapat sama atau berbeda dari tumbuhan inangnya dan mempunyai efek farmakologis.  Arthrinium sp. merupakan contoh jenis jamur endofit yang keberadaannya melimpah. Arthrinium sp. diketahui mempunyai kandungan metabolit sekunder yang potensial untuk dikembangkan. Senyawa golongan terpenoid, alkaloid, fenolik dan beberapa golongan lain ditemukan dalam jamur endofit Arthrinium sp. Senyawa yang dihasilkan oleh Arthrinium sp. dilaporkan menunjukkan aktivitas biologis yang beragam yaitu sebagai antimikroba, antioksidan, antikanker dan aktivitas yang lainnya. Tulisan ini merangkum pengetahuan, studi dan laporan mengenai jamur endofit Arthrinium sp., kajian aktivitas biologi serta metabolit sekunder yang dihasilkan yang berpotensi dikembangkan sebagai penemuan obat baru yang berasal dari alam.
Dendritic-Cell Specific Antigen Hiv-1: Novel Terapi Berbasis Biomolekuler sebagai Imunomodulator pada Penderita HIV Tipe 1
Authors: Salim Albert , Evananda Maria Pramesthi Sabrina , Prasetyo Aizar Vesa , Trapika I Gusti Made Gde Surya Chandra
Published: December 2021

Infeksi Human Immunodeficiency Virus (HIV), baik tipe 1 yang tersebar ke seluruh dunia maupun tipe 2 yang terisolasi di Afrika, masih menjadi tantangan di bidang kesehatan dunia termasuk Indonesia. Angka HIV yang tinggi ini penting untuk ditangani karena bahaya komplikasi yang mengintai. Penatalaksanaan dan terapi HIV yang ada saat ini dengan penggunaan antiretroviral memiliki keterbatasan dilihat dari efek terapi dan efek samping yang ditimbulkan. Pengembangan dan penemuan modalitas terapi yang memiliki potensi efek terapi yang lebih optimal merupakan suatu tantangan yang terus diupayakan dalam penanganan HIV ini. Salah satunya adalah pengembangan imunoterapi berbasis sel dendritik. Literature review ini ditulis secara sistematis mengenai laporan studi terkait hal di atas dari berbagai sumber termasuk Google Scholar, PubMed, Research Gate untuk menguraikan potensi sel dendritik sebagai imunomodulator pada penderita HIV-1. Modalitas imunoterapi ini dikonstruksi dalam bentuk vaksin berbasis sel dendritik, sel yang berperan pada patogenesis HIV, yang diadministrasikan secara intradermal. Vaksin yang diberikan akan menstimulasi respon imun dan dapat digunakan tidak saja sebagai upaya terapi pada penderita tapi berpotensi digunakan sebagai pencegahan.
PELATIHAN MENYUSUN KONTEN MULTIMEDIA INTERAKTIF UNTUK PARA GURU SDIT BINA INSAN CENDIKIA KELURAHAN LEUWIGAJAH KOTA CIMAHI
Authors: Kirom Mukhammad , Wibowo Edy , Qurthobi Ahmad , Andiani Linahtadiya
Published: December 2021

Kondisi saat ini dengan adanya pandemi Covid-19 hampir semua aspek kehidupan manusia terdampak. Salah satu aktivitas yang terpengaruh adalah proses belajar-mengajar di sekolah-sekolah, di mana biasanya dilakukan di kelas menjadi kegiatan pembelajaran di rumah berbasis daring. Jika proses pembelajaran di kelas, para guru dapat menjelaskan secara verbal dan bisa dibantu dengan alat peraga tentang materi tertentu. Hal ini tidak bisa dilakukan jika pembelajaran yang diberikan secara daring. Kasus ini dialami para guru yang ada di Sekolah Dasar Islam Terpadu Bina Insan Cendikia (SDIT-BIC) Cisalak Kelurahan Leuwigajah Kecamatan Cimahi Selatan Kota Cimahi. Para guru di SDIT-BIC saat ini menyampaikan pembelajaran hanya sebatas instruksi kepada murid untuk mempelajari materi dari buku atau bisa mencari materi dari internet. Hal ini tentu saja tidak bisa optimal dari aspek pemahaman mahasiswa. Sisi buruknya si anak atau murid tidak terpacu untuk belajar karena banyak hal yang tidak dipahami oleh murid. Berkaitan dengan ini pada tahap awal akan diberikan bagaimana membuat materi multimedia interaktif di mana bisa dibuat animasi sederhana untuk menerangkan materi menggunakan Microsoft Power Point. Pelatihan dilakukan sebagai transfer ilmu dan pengalaman tim penulis dalam menyusun materi kuliah daring. Kegiatan pelatihan diawali dengan diskusi antara para guru dengan tim penulis berkaitan kendala dalam penyampaian materi dan dilanjutkan dengan pelatihan menyusun materi multimedia interaktif. Selanjutnya para guru diminta membuat konten dan dievaluasi oleh tim penulis. Dari beberapa materi yang disusun sudah terlihat berupa materi multimedia interaktif.
Tecnificar la muerte. Los riesgos de deshumanizar los cuidados al final de la vida
Authors: García Sánchez Emilio , García Garcés Laura
Published: December 2021

Afrontar el final de una vida enferma para lograr una buena muerte requiere de unas necesidades tan genuinamente humanas que la ciencia y la técnica médica resultan insuficientes para satisfacerlas. Pero esta limitación no constituye una negación total de la existencia de elementos positivos en la inevitable tecnificación del proceso de morir que podrían contribuir a su humanización. Tras una revisión analítica de trabajos sobre los cuidados del enfermo que va a morir, concluimos que algunas razones, verdades y aspectos de la muerte, ni la ciencia ni la técnica médica logran entenderlas, y que, por tanto, son insuficientes para abordarla humanamente. En conclusión, proponemos los cuidados paliativos como la mejor alternativa para humanizar la muerte y contrarrestar algunos efectos negativos de su tecnificación actual.
Vacinação: do senso comum à consolidação do conhecimento científico
Authors: Loyola Carolina Fachetti , Silveira Gabriela Freitas da , Costa Isabella Colicchio de Paula , Frausino Laura Finotti , Taquary Laura  Rohlfs , Macedo Rhaísa Ghannam
Published: December 2021

Objetivo: Descrever o conhecimento de pacientes renais crônicos a respeito do Calendário Nacional de Imunização, assim como o cumprimento do processo vacinal. Métodos: Trata-se de um estudo transversal descritivo de abordagem quantitativa, conduzidos com 115 pacientes renais crônicos, com idade superior a 18 anos. Os dados foram coletados por meio de questionários transferidos para planilhas no Microsoft Excel Office, onde foram tabulados e descritos em forma de tabelas e gráficos. Posteriormente, foram analisados por estatística descritiva com auxílio do software IBM SPSS Statistics. O estudo foi aprovado por Comitê de Ética em Pesquisa. Resultados: A amostra, com média de idade de 55,5 ± 5,0 anos (27%), apresentou maioria masculina (58,3%); com o ensino fundamental completo (37,4%); renda familiar média, de até 1 salário-mínimo (44,3%). Destes, apenas 41,7% dos indivíduos foram alertados sobre a importância do calendário vacinal. Além disso, 86,1% alegaram acreditar que as vacinas fazem bem, em contradição aos 90,4% que mostraram cartões de vacina desatualizados. Conclusão: Conclui-se que existe um largo espaço entre o ideal e o real, no que tange às práticas de saúde para fins de vacinação e cumprimento assíduo do cartão vacinal, enfatizando sua importância e a problemática relacionada a ausência dessa prevenção.
Perfil epidemiológico de pacientes portadores de insuficiência cardíaca atendidos em um hospital de referência no Norte do Brasil
Authors: Carneiro Mauricio Soares , Reis Helder José Lima
Published: December 2021

Objetivo: Descrever as características sociodemográficas e clínicas de pacientes admitidos com diagnóstico de Insuficiência Cardíaca (IC) em um hospital público de referência no Norte do Brasil. Método Estudo observacional, transversal, descritivo, com caráter quantitativo, envolvendo 65 participantes internados em um hospital de referência com diagnóstico clínico de Insuficiência Cardíaca Congestiva (ICC) descompensada, no período de janeiro a dezembro de 2017. Foram incluídos no estudo, participantes maiores de 18 anos, que atingiram mais de 7 pontos nos critérios de Boston para diagnóstico da doença. Para comparar as causas de descompensação foram aplicados os testes do Qui-quadrado e de Kruskal-Wallis por meio do programa BioEstat versão 5.3. Resultados: A mediana da idade dos 65 participantes foi de 64 anos, 56,9% eram homens. Os principais fatores associados à IC foram hipertensão arterial (66,2%), tabagismo (70,8%) e sedentarismo (63,1%). As principais etiologias foram cardiopatia hipertensiva (23%), cardiopatia isquêmica, cardiomiopatia idiopática e doença valvar (18,5% cada). As principais causas de descompensação observadas foram disfunção valvar (26,1%) e infecção (15,3%). Conclusão: A compreensão da doença, dos fatores associados, do tratamento, bem como o acesso aos serviços básicos da rede de saúde pública devem ser priorizados para a melhora da assistência na região Norte do país.
Role of FSUE “Atomflot” in the implementation of programs for the rehabilitation of nuclear legacy facilities and in the system of spent nuclear fuel and radioactive waste management in the Murmansk region
Authors:   FSUE Atomflot, Kashka M.M. , Efanskaya E.A. ,   FSUE Atomflot, Matviishina K.A. ,   Moscow office of FSUE “Atomflot”, Tkachenko D.A. ,   FSUE Atomflot, Bogdanov A.Y. ,   FSUE Atomflot, Kobzev V.A. ,   FSUE Atomflot
Published: December 2021

The article provides an overview of the FSUE Atomflot activities aimed at improving the infrastructure and production facilities for the management of spent nuclear fuel and radioactive waste at FSUE Atomflot and ensuring nuclear, radiation and environmental safety, both in the Murmansk region and throughout the northwestern region of Russia. Carrying out work within the Federal Target Program “Ensuring nuclear and radiation safety for 2016—2020 and for the period up to 2030” in cooperation with production structures of both Rosatom and other federal and regional departments responsible for the ecological situation in the region also takes an important place.
Geoinformation analysis of soil cover protection in the Arctic Zone of the Russian Federation
Authors:   Institute of Basic Biological Problems of the RAS, Prisyazhnaya A.A. , Chernova O.V. ,   A.N. Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences, Mitenko G.V. ,   Institute of Physical, Chemical and Biological Problems of Soil Science of RAS, Snakin V.V. ,   Lomonosov Moscow State University
Published: December 2021

The representativeness of the soil diversity in the network of nature protected areas of the Russian Arctic was calculated on the basis of the Soil Map of the Russian Federation, 1:2.5 M scale by using geoinformation analysis. The authors estimated soil cover composition and soil contours areas using the ArcView GIS system. They have identified 90 different soils and soil complexes in the Arctic zone of Russia, 30 of them belong to the Arctic and tundra soils and occupy 47% of total Russian Arctic zone area. In the nature reserves and national parks territory, 48 different soils and soil complexes have been identified, 15 of them belong to the group of arctic and tundra soils, which occupy 60% of the area of protected areas. The investigation shows that currently the existing system of the Arctic protected areas is characterized by high representation of the taxonomic soil diversity (the representativeness indicator is 94%). The only soil type, Arctic Gleezem (Turbic Criosols), is not territorial protected within its typical distribution areas. To optimize the system of Arctic protected areas, the authors propose to adjust the boundaries of the existing nature protected areas in the Anadyr River basin, as well as to consider the possibility of organizing a protected area in the southern part of the Novaya Zemlya Archipelago.
The tribal community of the indigenous peoples of the North in the system of traditional nature management
Authors:   М. К. Ammosov North-Eastern Federal University, Sleptsov A.N.
Published: December 2021

The article considers the role and place of nomadic tribal communities of indigenous peoples of the North in administration of traditional nature management. It is shown that the emergence of such communities is due to a profound transformation of economic relations in the Arctic in the context of the transition to new economic conditions in the 90s of the XX century. The author gives the characteristic of such tribal communities in the municipal areas of the Arctic zone of the Republic of Sakha (Yakutia). Using the example of the nomadic tribal community “Omoloy” in the Ust-Yansky district of the republic, he shows its role in the development of traditional nature management, ensuring employment and income of the local population. The author presents the scheme of interaction of the tribal community as a primary production unit with government authorities and other economic entities to ensure the socio-economic development of the Arctic territories and substantiates the measures for the harmonization of relations between tribal communities and mining companies in the context of the Arctic industrial development.
Features ensuring food security for the population of the North and Arctic of Russia
Authors:   Institute of socio-economic and energy problems of the North, Komi Science Centre Ural Branch of the RАS, Ivanov V.A.
Published: December 2021

The article reveals the northern and Arctic specifics of food security, including unfavorable conditions for agriculture, low provision of biological resources, a decrease in the level of self-sufficiency of the population in agricultural products, and a high dependence of food on imports. The author considers risks and threats to food security and measures to overcome them. The main directions of ensuring food security related to the availability of domestic and imported food products, improving the quality of life, and reducing the poverty of citizens are proposed.
THE CONCEPT OF "ANTHROPOCENTRISM" IN MODERN LINGUISTICS
Authors:   Uzbekistan State University of World Languages, Bazarbaeva Albina
Published: December 2021

The article examines the Modern linguistics studies language from an anthropocentric perspective, as language captures all changes that occur to humans. Anthropology studies the physical and cultural development of humanity, and therefore distinguishes between physical and cultural anthropology. Physical anthropology studies the biological origin of man and his evolution. Cultural anthropology is concerned with the formation and development of human culture, and in particular, studies the way of life, mentality, national character, and spiritual, social, and labour activity. The verbal expression of reality varies from nation to nation, which is due to the specific historical and social conditions of their development.
SLEEP STAGES CLASSIFICATION BASED ON BIORADAR USING CNN-LSTM NEURAL NETWORK
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Fedorin Illia , Ivanova Yana ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”
Published: December 2021

The research is devoted to the automatic sleep stages classification based on non-invasive biosensor. A deep learning framework for classification of wakefulness, REM and NREM sleep stages (N1, N2, and N3) is proposed. The system consists of a combined convolutional and recurrent (long short-term memory, LSTM) neural network (CNN-LSTM). The proposed CNNLSTM neural network significantly outperforms existing machine learning methods based on traditional manual feature engineering. The model achieves an accuracy of 0.88 and a Cohen's Kappa agreement coefficient of 0.84, that is almost perfect agreement. The results of the study could be a promising solution for automatic sleep assessment without manual data processing and can be very useful for sleep screening.
Domestic and foreign experience in the application of methods and technologies of selection for police service
Authors: Краснов Иван Васильевич
Published: December 2021

В статье рассмотрена проблема качественного подбора и отбора кандидатов на службу в территориальные органы (подразделения) Росгвардии. Психологический отбор, вместе с его психофизиологической составляющей, представляет собой часть профессионального отбора, направленный на выявление таких сотрудников, которые по своим моральным, психофизиологическим и психологическим качествам, наиболее соответствуют конкретным требованиям будущей деятельности. В то же время высокоэффективный психологический отбор должен иметь комплексный подход, который соответствует двум принципам, первый – это принцип дифференцированности и динамичности, второй – надежность и прогностичность применяемых методик. Рассмотрен опыт применения полиграфа в полиции в ходе кадровой работы. Представлены результаты изучения кандидатов на работу в частные организации и на службу в Росгвардию. Профессиональный психологический отбор также рассматривается как комплекс мероприятий, направленных на обеспечение качественного отбора персонала организации на основе оценки соответствия уровня развития необходимых психофизиологических (индивидных) качеств и свойств личности требованиям профессиональной деятельности. Обобщены социально-психологические и личностные характеристики кандидатов, выявляемые в процессе психодиагностических исследований и негативно влияющие на прохождение ими дальнейшей службы.

The article considers the problem of qualitative selection and selection of candidates for service in the
territorial bodies (divisions) of the Rosgvardiya. Psychological selection, together with its psychophysiological
component, is a part of professional selection aimed at identifying such employees who, according to their moral,
psychophysiological and psychological qualities, most correspond to the specific requirements of future activity.
At the same time, highly effective psychological selection should have an integrated approach that corresponds
to two principles, the first is the principle of differentiation and dynamism, the second is the reliability and
prognosticality of the methods used. The experience of using a polygraph in the police in the course of personnel
work is considered. The results of the study of candidates for work in private organizations and for service in the
Rosgvardiya are presented. Professional psychological selection is also considered as a set of measures aimed
at ensuring a high-quality selection of the organization's personnel based on an assessment of the compliance
of the level of development of the necessary psychophysiological (individual) qualities and personality properties
with the requirements of professional activity. The socio-psychological and personal characteristics of
candidates identified in the process of psychodiagnostic research and negatively affecting their further service
are summarized.
Impacts of Drugs on Alzheimer’s Diseases
Authors:   Department of Chemistry, University Institute of Science, Chandigarh University, Gharuan, Mohali, Punjab, India, R Bharti
Published: December 2021

In 1901, Alois Alzheimer first reported Alzheimer’s disease. It is a disease that destroys memory and other essential mental functions mostly observed in an older person and mainly in women. Various treatment techniques have been used, which involve Ayurveda, homeopathy, modern drugs, etc. Turmeric, Ashwagandha, Brahmi, Ghrita, etc. are some ayurvedic medicines used to cure this disease, but they were relatively slow in processing. Drugs like Donepezil, Galantamine, and Rivastigmine are speedy, and thus they are in the market nowadays. In this review article, we will give information and awareness about the drugs therapy used for disease treatment and their effects.
Redox-addressable single-molecule junctions incorporating a persistent organic radical
Authors: Naghibi Saman , Sangtarash Sara , Kumar Varshini J. , Wu Jian-Zhong , Judd Martyna M. , Qiao Xiaohang , Gorenskaia Elena , Higgins Simon J. , Cox Nicholas , Nichols Richard J. , Sadeghi Hatef , Low Paul J. , Vezzoli Andrea
Published: December 2021

The integration of radical (open-shell) species into single-molecule junctions at non-cryogenic temperatures is a key to unlocking the potential of molecular electronics in further applications. While many efforts have been devoted to this issue, in the absence of a chemical or electrochemical potential the open-shell character is lost when in contact with the metallic electrodes. Here, the organic 6-oxo-verdazyl radical, which is stable at ambient temperatures and atmosphere, has been functionalised by aurophilic 4-thioanisole groups at the 1,5-positions and fabricated into a molecular junction using the scanning tunnelling microscope break-junction technique. The verdazyl moiety retains open-shell character within the junction even at room temperature, and electrochemical gating permits in-situ reduction of the verdazyl to the closed-shell anionic state in a single-molecule transistor configuration. In addition, the bias-dependent alignment of the open-shell resonances with respect to the electrode Fermi levels gives rise to purely electronically-driven rectifying behaviour. The demonstration of a verdazyl-based molecular junction capable of integrating radical character, transistor-like switching behaviour, and rectification in a single molecular component under ambient conditions paves the way for further studies of the electronic, magnetic, and thermoelectric properties of open-shell species.
Independent gradient model based on Hirshfeld partition (IGMH): A new method for visual study of interactions in chemical systems
Authors: Lu Tian , Chen Qinxue
Published: December 2021

The independent gradient model (IGM) originally proposed in Phys. Chem. Chem. Phys., 19, 17928 (2017) has been increasingly popular in visual analysis of intramolecular and intermolecular interactions in recent years, and it has many clear advantages over the widely employed noncovalent interaction (NCI) method, such as intrafragment and interfragment interactions can be elegantly isolated and thus separately studied, the isosurfaces are smoother and less jaggy. However, we frequently observed that there is an evident shortcoming of IGM map in graphically studying weak interactions, that is its isosurfaces are usually too bulgy; in these cases, not only the graphical effect is poor, but also the color on some areas on the isosurfaces is inappropriate and may lead to erroneous analysis conclusions. In addition, the IGM method was originally proposed based on promolecular density, which is quite crude and does not take actual electronic structure into account. In this article, we first present a detailed overview of the IGM analysis, and then propose our new variant of IGM, namely IGM based on Hirshfeld partition of molecular density (IGMH), which replaces the free-state atomic densities involved in the IGM method with the atomic densities derived by Hirshfeld partition of actual molecular electron density. This change makes IGM have more rigorous physical background. In addition, we describe some indices defined on the top of IGM or IGMH framework to quantify contributions from various atoms or atom pairs to interaction between specific fragments. A large number of application examples in this article, including molecular and periodic systems, weak and chemical bond interactions, fully demonstrate the important value of IGMH in intuitively understanding interactions in chemical systems. Comparisons also showed that the IGMH usually has markedly better graphical effect than IGM and overcomes known problems in IGM. Currently IGMH analysis has been efficiently supported in our freely available and user-friendly wavefunction analysis code Multiwfn (http://sobereva.com/multiwfn), and a detailed tutorial is presented. We hope that IGMH will become a new popular method among chemists for exploring interactions in wide variety of chemical systems.
Thermal Stability and Decomposition Pathways in Volatile Molybdenum(VI) Bis-Imides
Authors: Land Michael , Bacic Goran , Robertson Katherine , Barry Sean
Published: December 2021

The vapor deposition of many molybdenum-containing films relies on the delivery of volatile compounds with the general bis(tert-butylimido)molybdenum(VI) framework, both in atomic layer deposition and chemical vapor deposition. We have prepared a series of (tBuN)2MoCl2 adducts using neutral N,N’-chelates and investigated their volatility, thermal stability, and decomposition pathways. Volatility has been determined by thermogravimetric analysis, with the 1,4-di-tert-butyl-1,3-diazabutadiene adduct (5) found to be the most volatile (1 Torr of vapor pressure at 135 ºC). Thermal stability was measured primarily using differential scanning calorimetry, and the 1,10-phenanthroline adduct (4) was found to be the most stable, with an onset of decomposition of 303 ºC. We have also investigated molybdenum compounds with other alkyl-substituted imido groups: these compounds all follow a similar decomposition pathway, γ-H activation, with varying reaction barriers. The tert-pentyl, 1-adamantyl, and a cyclic imido (from 2,5-dimethylhexane-2,5-diamine) were systematically studied to probe the kinetics of this pathway. All of these compounds have been fully characterized, including via single-crystal X-ray diffraction, and a total of 19 unique structures are reported.
Curcumin therapy: Immune booster in present and post-pandemic (COVID-19) Era
Authors: Shubha P  , Shyamsundar S  , Manjunatha H B
Published: December 2021

COVID-19 pandemic, which has traumatized the world population, in principle, is an inflammatory lung disease secondary to SARS-COV2 virus infection. Inflammatory lung injury progressing to Acute Respiratory Distress Syndrome (ARDS) is a recognized clinical feature of the disease. Inflammatory cytokines released in response to COVID-19 activate the transcription factor - the nuclear factor-қB (NF-қB) and series of pro-inflammatory cytokines, which are responsible for lung injury. Accurate yet precise treatment of coronavirus disease still remains inconclusive, and intervention is mainly symptomatic treatment, respiratory support, antiviral therapies and vaccination. Currently, the major focus of therapy is on reducing lung inflammation by elevating the host immunity. In this scenario, NF-қB inhibition can be conceptualized as a promising approach to down-regulate the overproduction of cytokines, such that inflammatory lung tissue injury could be prevented in COVID-19 infected patients. Towards this, curcumin from Curcuma longa (Turmeric) would play a vital role in the intervention and suppress NF-қB activation via translocation of p65 into the nucleus. Moreover, Curcumin is a proven therapeutic agent against various inflammatory pathologies as it also has the potential to inhibit the expression of certain genes that are critical for the regulation of inflammation.  Keeping this phenomenon and the current medical significance in view, we have explored and computed the anti-inflammatory properties of curcumin to develop it as a potent therapeutic agent to prevent NF-қB induced lung tissue injury in COVID-19 with the main goal of elevating immunity in the post-covid-19 situations as well as in healthy human beings.
FACTORS ASSOCIATED WITH THE OUTCOMES IN THE TREATMENT OF TUBERCULOSIS IN PEOPLE MONITORED BY PRIMARY HEALTH CARE
Authors: Rodrigues Jamylle Souza , Góes Marco Aurélio De Oliveira
Published: December 2021

Introduction: Tuberculosis (TB) represents a challenge that go through the history of mankind. The monitoring in the Primary Health Care (PHC) consists in an important mechanism of accomplishment of the policies on TB, since it provides greater longitudinal care relationship (longitudinality) and closeness to the infected individual. Objective: To analyze TB cases attended by the PHC in Sergipe. Outline: It was performed a retrospective cohort of the TB cases attended by the PHC in Sergipe between 2014 and 2018. Results: 2,172 TB cases attended by the PHC in Sergipe were included, of which 283 (13.0%) abandoned the treatment, 1813 (83.5%) progressed to cure and 76 (3.5%) to death. The factors associated with treatment abandonment were: male, age range of 20 to 29 years, alcoholics, people with diabetes mellitus and persons deprived of liberty. In relation to the mortality, higher rates were found in: male, age range of 70 years and above, illiterate and people with diabetes mellitus. Implications: Conditions of social vulnerability and comorbidities impacted mortality, as well as abandonment of TB treatment.
INFLUENCE OF PATIENT’S GENERAL HEALTH STATUS ON THE OUTCOME OF INFECTIONS
Authors: Coraça-Huber Débora Cristina
Published: December 2021

The outcomes of a pathogen colonization and development of clinical infection can be strictly related to the general health status of a patient. The spread of the awareness about the dangers of underlying health conditions should be the main role of the conventional medicine, as well as the key to successful treatments and control of diseases.
On Geometric Constants for Discrete Morrey Spaces
Authors: Adam Adam , Gunawan Hendra
Published: December 2021

In this paper we prove that the n-th Von Neumann-Jordan constant and the n-th James constant for discrete Morrey spaces lpq where 1≤p<q<∞ are both equal to n. This result tells us that the discrete Morrey spaces are not uniformly non-l1, and hence they are not uniformly n-convex.
CONCEPT OF COMPETENCE IN THE CIRCULAR ECONOMY IN THE INTERNATIONAL SCIENTIFIC DISCOURSE
Authors: Sysoyev Oleksiy
Published: December 2021

The article presents an analysis of the concept of “competence in the circular economy” in the international scientific area. This analysis was carried out through the study of foreign scientific literature, in particular, modern reports of educational organizations, projects, guidelines of leading universities and publications on this issue. The components of competence in circular economy are shown, the detailed content of competences in circular economy, the matrix of competences in circular economy consists of five levels of training, comparable to Bloom's taxonomy. The didactic approach to training is given. It is concluded that this is a complex concept, understood in a broader and narrower sense. In a broad, general sense, “competence in the circular economy” includes the components needed to make decisions in complex transition processes, in particular systems thinking, design, and multi-perspective thinking, which are integrated with innovative competencies. In a narrow sense, “competence in a circular economy” includes components specific to a particular professional field.
PROBLEMS AND PROSPECTS OF TOURISM EDUCATION DEVELOPMENT IN UKRAINE
Authors: Зубехіна Тетяна , Terletsky Volodymyr , Olhova-Marchuk Natalia , Kushnir Volodymyr
Published: December 2021

The article analyzes the problems and prospects of tourism education in Ukraine. It is established that the level of socio-cultural development of any country directly depends on the level of development of the tourism industry and the relevant qualifications of human resources.

It was found that today there is a need to train professionals in the field of tourism, who have competencies in the use of new technologies and software, marketing tools to promote tourism products and services, communication and psychological skills, orientation in modern trends in tourism and etc.

The normative-legal base of tourism education systems in Ukraine is considered. It is determined that our country is still on the way to implementing key existing laws and regulations aimed at the Europeanization of education, including tourism education.

The impact of the COVID-19 pandemic on the education system, in particular in the field of tourism, has been studied. It is concluded that the availability of an education and training system suitable for the digital age is very important in modern conditions.

It is established that future specialists in the field of tourism do not have sufficient practical experience after graduating from higher education institutions. It is concluded that their practical training plays an important role in the training of future highly qualified employees.

The necessity of using foreign experience in training specialists in the field of tourism, which will help domestic tourism education to enter the international standardized system, is substantiated.

Perspective directions of modernization of the domestic system of tourist education in the context of European integration processes are outlined, namely: strengthening of the practical component of tourist education, providing access to foreign internships; adjustment of educational programs taking into account world trends and needs of tourists; stimulating students and teachers to international exchange of experience and internships, etc.
CRITICAL THINKING AS THE BASIS OF MODERN EDUCATIONAL APPROACHES IN THE FORMATION OF STUDENT PERSONALITY
Authors: Horban Oleksander , Fediuk Vladyslava
Published: December 2021

The article postulates that the formation of critical thinking in the individual is a significant challenge of the modern education system, which should offer the latest methodology for personal development of relevant skills to acquire new knowledge and critically evaluate various information flows under the influence of modern man. It is argued that the formation of a strong, conscious personality of the student is identical to the formation of a conscious citizen, which is actually aimed at the New Ukrainian School. First of all, it is expressed in the direction of the development of logic and critical as well as creative thinking. All these three important areas of the learning process contribute to the student's self-reflection and the formation of his personal life position. It is noted that today the public inquiry requires the skills to independently analyze information, to constantly conduct search activities. Learning ceases to be memorization, it appears as a conversation with the teacher, which leads to qualitatively new judgments. That is, modern learning is a triad: search, direct conversation and judgment. Assertive behavior is suggested as the optimal, most constructive way of interpersonal interaction in the learning process. In addition, the personality is formed on the principles of assertiveness, which has critical thinking, expresses its own "I", much less likely to be manipulative. It is concluded that the development of critical thinking is not just an integral part of the modern educational process. The student's ability to think critically, to express his own opinion, unbiased position, is a necessary learning outcome that allows modern man to form a reality-appropriate type of worldview.
PROFESSIONAL IMAGE OF A FUTURE TEACHER OF FOREIGN LITERATURE: FROM LEARNING TO PRACTICE
Authors: Грицак Наталія
Published: December 2021

The article deals with the formation of the professional image of the future foreign literature teacher. The semantic content of the concept of professional image of a teacher is analyzed and supplemented. The structural components influencing the effective formation of the professional image of the future teacher are highlited and described. It is shown that pedagogical skills, visual image, internal appearance are important components in the structure of the professional image of the future teacher. With the peculiarities of the school subject «Foreign Literature», the specifics of forming the professional image of the future foreign literature teacher are justified. The essence of the concept of professional image of the future foreign literature teacher is revealed. The structure of professional image of future foreign literature teachers, which consists of personal, professional, socio-cultural, communicative, motivational-target, result-analytical components is developed. The basic and specific abilities that contribute to the productive formation of the professional image of the future foreign literature teacher are considered. A survey of fourth-year students of the Faculty of Foreign Languages of Volodymyr Hnatyuk Ternopil National Pedagogical University was conducted. The aim of the poll was to find out the attitude of students to future pedagogical activities, to identify their vision of the concepts of «professional image of a teacher», «professional image of a foreign literature teacher». The results showed that the most students consider the concept of professional image of a foreign literature teacher as a set of external, personal and professional qualities that permit the most effectively realise the educational process. The obtained results confirmed that the productive formation of the professional image of the future foreign literature teacher is based on interrelated abilities, particulary basic, linguistic, specific.
Producción de plántulas de chile habanero con fertilización orgánica y biológica
Authors: Luna-Fletes Jonás Alan , Cruz-Crespo Elia , Can-Chulim Álvaro , Chan-Cupul Wilberth , Luna-Esquivel Gregorio , García-Paredes Juan Diego , Mancilla-Villa Oscar Raúl
Published: December 2021

En los sistemas de cultivo se busca sustituir la fertilización química; por esto, se propone la alternativa de combinar a la composta con los fertilizantes orgánicos líquidos y biofertilizantes, para la obtención de plántulas de chile habanero de calidad. El objetivo de la investigación fue evaluar dos fertilizantes orgánicos líquidos en combinación con Purpureocillium lilacinum y Beauveria brongniartii en el crecimiento, concentración nutrimental y calidad de plántulas de chile habanero sobre el sustrato peat moss/composta, con el fin de sustituir la fertilización química. Se utilizó un diseño experimental completamente al azar con arreglo bifactorial, los factores fueron los fertilizantes orgánicos líquidos (lixiviado de vermicomposta y el producto comercial Pez Terra®, que sediluyeron en agua en una relación 1:200), y los biofertilizantes (B. brongniartii y P. lilacinum), también se evaluó un testigo (solución nutritiva de Steiner al 25%). Se encontró que las plántulas que se trataron con el producto comercial incrementaron su crecimiento, unidades SPAD, concentración de N, P y K, y la calidad; con la inoculación de P. lilacinum aumentó la altura de plántula, diámetro de tallo, área foliar, concentración de N e índice de esbeltez, con respecto a B. brongniartii. La interacción del fertilizante comercial y P. lilacinum, más el uso del sustrato peat moss/composta 1:1 (v/v), incrementaron la altura de plántula en 10%, área foliar en 35%, concentración de N en 57% y P en 35%, e índice de esbeltez en 8% en comparación con las plántulas que se produjeron con la solución nutritiva de Steiner al 25% y peat moss, por lo que esta combinación se consideró viable para la producción de plántulas de chile habanero y sustituir la fertilización química.
“WAS SIE ANRÜHREN, SCHMILZT”. THOMAS BERNHARD’S PAINTER STRAUCH AND THOMAS MANN’S JESUIT NAPHTA
Authors:   Moscow State Linguistic University, Belyakov Dmitry A.
Published: December 2021

This article is devoted to a comparative analysis of the images of the painter Strauch, the character in the novel by Th. Bernhard “Frost”, and the Jesuit Naphta, the character of Th. Mann’s “The Magic Mountain”. Such a research perspective is due to the fact that in the work of the Austrian and German classics many characteristic leitmotifs like the crisis of the subject and the search for the Self, the ambivalent being of the artist, the theme of rejection of a career, the theme of illness and death, all go back to those figures. A comparative analysis of the images of Strauch and Naphta allows shedding additional light on the specificity of Th. Bernhard’s reception of Th. Mann’s work, as well as expanding the idea of the artistic originality of the сharacter-“anti-educator” requested by the novel of the 20th century. While the differences between an artist and Jesuit are predominantly formal, their similarities reveal a conceptual systemic basis. Strauch and Naphta are related by Ungrund (groundlessness): both willingly appeal to the “prelogical”, both are prone to introversion, misanthropy and nihilism. It is emphasized that the internal conflict experienced by Strauch and Naphta allows them to feel much more subtly the drama of the “spiritual situation of time”. Without denying the self-destructive intellectual and ideological orientation of Strauch and Naphta, the author of the article comes to the conclusion that it is necessary to underline the cognitively constructive potential of their problematizing “pedagogy”.