bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Viscosity Implicit Approximation Method for Solving Variational Inequalities over the Common Fixed Points of Nonexpansive Mappings in Symmetric Hilbert Space
Authors: Sun Linqi , Xu Hongwen , Ma Yan
Published: May 2023

In this paper, based on the viscosity approximation method and the hybrid steepest-descent iterative method, a new implicit iterative algorithm is presented for finding the common fixed points set of a finite family of nonexpansive mappings in a reflexive Hilbert space, which is called a symmetric space. We prove that the sequence generated by this new implicit rule strongly converges to the unique solution of a class of variational inequalities under certain appropriate conditions of the parameters. Moreover, we also study the applications to a broader family of strictly pseudo-contractive mappings and generalized equilibrium problems that involve several variational inequality problems, optimization problems, and fixed-point problems. Finally, numerical results are provided to clarify the stability and effectiveness of the algorithm and to compare with some existing iterative algorithms.
Dynamics of Medical Screening: A Simulation Model of PSA Screening for Early Detection of Prostate Cancer
Authors: Karanfil Özge
Published: May 2023

In this study, we present a novel simulation model and case study to explore the long-term dynamics of early detection of disease, also known as routine population screening. We introduce a realistic and portable modeling framework that can be used for most cases of cancer, including a natural disease history and a realistic yet generic structure that allows keeping track of critical stocks that have been generally overlooked in previous modeling studies. Our model is specific to prostate-specific antigen (PSA) screening for prostate cancer (PCa), including the natural progression of the disease, respective changes in population size and composition, clinical detection, adoption of the PSA screening test by medical professionals, and the dissemination of the screening test. The key outcome measures for the model are selected to show the fundamental tradeoff between the main harms and benefits of screening, with the main harms including (i) overdiagnosis, (ii) unnecessary biopsies, and (iii) false positives. The focus of this study is on building the most reliable and flexible model structure for medical screening and keeping track of its main harms and benefits. We show the importance of some metrics which are not readily measured or considered by existing medical literature and modeling studies. While the model is not primarily designed for making inferences about optimal screening policies or scenarios, we aim to inform modelers and policymakers about potential levers in the system and provide a reliable model structure for medical screening that may complement other modeling studies designed for cancer interventions. Our simulation model can offer a formal means to improve the development and implementation of evidence-based screening, and its future iterations can be employed to design policy recommendations to address important policy areas, such as the increasing pool of cancer survivors or healthcare spending in the U.S.
Socio-Environmental Risks Linked with Mine Tailings Chemical Composition: Promoting Responsible and Safe Mine Tailings Management Considering Copper and Gold Mining Experiences from Chile and Peru
Authors: Cacciuttolo Carlos , Cano Deyvis , Custodio María
Published: May 2023

There is a need to define mine tailings in a clear, precise, multidisciplinary, transdisciplinary, and holistic manner, considering not only geotechnical and hydraulic concepts but also integrating environmental and geochemical aspects with implications for the sustainability of mining. This article corresponds to an independent study that answers questions concerning the definition of mine tailings and the socio-environmental risks linked with mine tailings chemical composition by examining the practical experience of industrial-scale copper and gold mining projects in Chile and Peru. Definitions of concepts and analysis of key aspects in the responsible management of mine tailings, such as characterization of metallic–metalloid components, non-metallic components, metallurgical reagents, and risk identification, among others, are presented. Implications of potential environmental impacts from the generation of acid rock drainage (ARD) in mine tailings are discussed. Finally, the article concludes that mine tailings are potentially toxic to both communities and the environment, and cannot be considered as inert and innocuous materials; thus, mine tailings require safe, controlled, and responsible management with the application of the most high management standards, use of the best available technologies (BATs), use of best applicable practices (BAPs), and implementation of the best environmental practices (BEPs) to avoid risk and potential socio-environmental impact due to accidents or failure of tailings storage facilities (TSFs).
Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry
Authors: Kreutz Anna , Clifton Matthew S. , Henderson W. Matthew , Smeltz Marci G. , Phillips Matthew , Wambaugh John F. , Wetmore Barbara A.
Published: May 2023

Concern over per- and polyfluoroalkyl substances (PFAS) has increased as more is learned about their environmental presence, persistence, and bioaccumulative potential. The limited monitoring, toxicokinetic (TK), and toxicologic data available are inadequate to inform risk across this diverse domain. Here, 73 PFAS were selected for in vitro TK evaluation to expand knowledge across lesser-studied PFAS alcohols, amides, and acrylates. Targeted methods developed using gas chromatography–tandem mass spectrometry (GC-MS/MS) were used to measure human plasma protein binding and hepatocyte clearance. Forty-three PFAS were successfully evaluated in plasma, with fraction unbound (fup) values ranging from 0.004 to 1. With a median fup of 0.09 (i.e., 91% bound), these PFAS are highly bound but exhibit 10-fold lower binding than legacy perfluoroalkyl acids recently evaluated. Thirty PFAS evaluated in the hepatocyte clearance assay showed abiotic loss, with many exceeding 60% loss within 60 min. Metabolic clearance was noted for 11 of the 13 that were successfully evaluated, with rates up to 49.9 μL/(min × million cells). The chemical transformation simulator revealed potential (bio)transformation products to consider. This effort provides critical information to evaluate PFAS for which volatility, metabolism, and other routes of transformation are likely to modulate their environmental fates.
BNT162b2 COVID-19 Vaccines in Children, Adolescents and Young Adults with Cancer—A 1-Year Follow-Up
Authors: Donze Caroline , Min Victoria , Ninove Laetitia , de Lamballerie Xavier , Revon Rivière Gabriel , Verschuur Arnauld , Saultier Paul , André Nicolas
Published: May 2023

(1) Background: Children and young adults with cancer are poorly represented in COVID-19 vaccination studies, and long-term protection conferred by vaccination is not known. (2) Objectives: 1. To determine the adverse effects associated with BNT162B2 vaccination in children and young adults with cancer. 2. To assess its efficacy in stimulating immunological response and in preventing severe COVID-19 disease. (3) Methods: Retrospective single-center study evaluating patients aged 8 to 22 years, with cancer, who underwent vaccination from January 2021 to June 2022. ELISA serologies and serum neutralization were collected monthly from the first injection. Serologies below 26 were considered negative, while those above 264 BAU/mL were considered positive and indicative of protection. Antibodies titers were considered positive above 20. Data on adverse events and infections were collected. (4) Results: 38 patients were included (M/F = 1.7, median age 16 years), of whom 63% had a localized tumor and 76% were undergoing treatment at the time of the first vaccination. Two or three vaccine injections were administered in 90% of patients. Adverse events were mainly systemic and not severe, except for seven grade 3 toxicities. Four cancer-related deaths were reported. Median serology was negative the month following the first vaccination and became protective during the third month. At 3 and 12 months, median serology was 1778 and 6437 BAU/mL, respectively. Serum neutralization was positive in 97% of the patients. COVID-19 infection occurred despite vaccination in 18%; all were mild forms. (5) Conclusions: In children and young adults with cancer, vaccination was well tolerated and conferred effective serum neutralization. COVID-19 infections were mild, and vaccine seroconversion persisted after 12 months in most patients. The value of additional vaccination should be further established.
Waldenström’s Macroglobulinemia in a Normoproteinemic Dog with Atypical Bimorphic Plasmacytoid Differentiation and Monoclonal Gammopathy
Authors: Guerlin Maud , Mourou Kévin , Martini Valeria , Soetart Nicolas , Comazzi Stefano , Trumel Catherine , Granat Fanny
Published: May 2023

A 2-year-old neutered female Small Munsterlander dog was presented for an insect bite. Physical examination revealed a poor body condition, a peripheral lymphadenomegaly, and suspected splenomegaly. A complete blood count (Sysmex XN-V) revealed marked leukocytosis with lymphocytosis and abnormal dot plots. An abnormal monomorphic lymphoid population and marked rouleaux formation were noted on the blood smear. Lymph node aspirates contained an atypical bimorphic population of lymphocytes, either with a plasmacytoid or a blastic appearance. This double population was also found in the spleen, liver, bone marrow, tonsils, and other tissues. Peripheral blood and lymph node clonality assays revealed clonal BCR gene rearrangement. Flow cytometry revealed a mixed population of small-sized B-cells (CD79a+ CD21+ MHCII+) and medium-sized B-cells (CD79a+ CD21− MHCII−) in lymph nodes and a dominant population of small-sized mature B-cells (CD21+ MHCII+) in peripheral blood. Though normoproteinemic, serum protein electrophoresis revealed an increased α2-globulin fraction with an atypical restricted peak, identified as monoclonal IgM by immunofixation. Urine protein immunofixation revealed a Bence-Jones proteinuria. A diagnosis of Waldenström’s macroglobulinemia was made. Chemotherapy was initiated, but the dog was euthanized 12 months after the initial presentation due to marked clinical degradation.
A Review of Research Methods and Evolution Mechanisms of Landslide-Induced Tsunamis
Authors: Xin Chunlei , He Zhiqian , Feng Wenkai
Published: May 2023

The research on landslide surge has always been a hot issue in the research of engineering geology, geological disasters and hydraulics in both domestic and foreign circumstances. Based on the research status and achievements of landslide surge, this paper mainly reviews the research methods of landslide surge including numerical simulation methods, theoretical analysis methods and physical methods. The first part summarized the examples of geological disaster surge and the classification, characteristics and influencing factors of geological disaster surge. In the second part, the research methods of landslide surge are summarized. Firstly, the theoretical analysis progress of landslide surge in recent years is summarized. Secondly, the present situation of physical model test is summarized from four aspects: model, surge generation, surge propagation and surge run-up. Finally, the numerical simulation methods are summarized from the generation and propagation of surge. The third part discussed the influence factors of landslide surge. In the next part, the difficult problems and research status of landslide surge are evaluated. Finally, the study of landslide surge is prospected from the perspective of various factors of landslide surge.
Application of Different Weighting Schemes and Stochastic Simulations to Parameterization Processes Considering Observation Error: Implications for Climate Change Impact Analysis of Integrated Watershed Models
Authors: Lee Eunhee , Lee Hyeonju , Park Dongkyu , Hwang Hyoun-Tae , Park Changhui
Published: May 2023

We investigated the potential impact of observation error on the calibration performance of an integrated watershed model. A three-dimensional integrated model was constructed using HydroGeoSphere and applied to the Sabgyo watershed in South Korea to assess the groundwater–surface water interaction process. During the model calibration, three different weighting schemes that consider observation error variances were applied to the parameter estimation tool (PEST). The applied weighting schemes were compared with the results from stochastic models, in which observation errors from surface discharges were considered a random variable. Based on the calibrated model, the interactions between groundwater and surface water were predicted under different climate change scenarios (RCP). Comparisons of calibration performance between the different models showed that the observation-error-based weighting schemes contributed to an improvement in the model parameterization. Analysis of the exchange flux between groundwater and surface water highlighted the significance of groundwater in delaying the hydrological response of integrated water systems. Predictions based on different RCP scenarios suggested the increasing role of groundwater in watershed dynamics. We concluded that the comparison of different weighting schemes for the determination of error covariance could contribute to an improved characterization of watershed processes and reduce the model uncertainty arising from observation errors.
Aplicación de nitrógeno en el cultivo de maíz endiferentes estadios fenológicos
Authors: Lugo Pereira Wilfrido Daniel , López Ávalos Derlys Fernando , Florencio González Laura Rocio , Morel López Eulalio , Sánchez Jara Raúl , Mongelos Barrios Carlos Alberto
Published: May 2023

El cultivo del maíz tiene mucha importancia en Paraguay, siendo principal rubro de los productores de la zona, por esta razón es necesario la aplicación de fertilizante nitrogenado para incrementar la producción, además la importancia del momento de la aplicación. El objetivo del trabajo fue evaluar la aplicación de nitrógeno en diferentes estadios fenológicos en el cultivo de maíz. El experimento se realizó en Santa Elena, Distrito de Belén, Departamento de Concepción, Paraguay. El experimento realizado se utilizó un diseño de bloques completos al azar (DBCA), con esquema factorial (4 x 4), donde el factor A correspondió a dosis de nitrógeno (0, 35, 70 y 105 kg ha-1) y factor B momento de aplicación en estados fenológicos (V1, V3, V6 y V9), con tres repeticiones. Los datos obtenidos fueron evaluados estadísticamente por el Test F y las medias fueron comparadas por el test de Tukey al 5 %, además se realizó el análisis de regresión. Las determinaciones evaluadas fueron la altura de planta, altura de inserción de la mazorca, longitud de la mazorca, diámetro de la mazorca y el rendimiento de granos del maíz. El resultado de análisis en la altura de planta y altura de inserción de mazorca mostró significancia en la dosis de nitrógeno, las otras determinaciones se observaron interacciones entre los factores y se ajustaron a una ecuación cuadrática. La combinación de las dosis de N con diferentes estados fenológicos aumenta de manera significativa el rendimiento del maíz.
Collaborative Governance in Local Government’s Policy Process: A Comparative Case Study on General University Hospital Hosting Initiatives in Yeosu and Gunsan
Authors:   The Korean Association 0f Ngo Studies, Jung Geum Chil , Cho Jung-Kwan
Published: May 2023

Drawing on Ansell and Gash(2007)’s Collaborative Governance model, this study attempts to explain how and why a city succeeds in making a policy solution in the seemingly non-partisan, re-distributive tasks such as inviting a General University Hospital to a locality. A basically identical policy initiatives taken by two mostly similar port cities (Yeosu and Gunsan) in Cholla region, Korea are compared. Collaborations among local power elites, university hospital leaders and local civil society organizations are analyzed through both elite interviews and observations on the flow of events. Efforts by Gunsan was successful while that by Yeosu was not. Itemized analyses find that the policy process in both cities commonly show low-level collaborative governance, especially in the domains of accountability and responsiveness. That in Gunsan, nevertheless, shows a comparatively higher-level collaboration among the actors in the domains of participation, autonomy, network, openness, trust and institutionalization. The researchers interpret it as the key to the success. In conclusion they emphasize both voluntary collaboration, trust-building and network-making among actors in the process.
The effect of psychological therapies on treatment efficacy of temporo-mandibular disorders
Authors: Kinkulkina M.A. , Knyaseva M.V. , Samokhlib Ya.V. , Shelemetieva G.N. , Egiazaryan A.A.
Published: May 2023

Temporomandibular disorders are characterized by high prevalence and difficulty in diagnosis and treatment. Along with organic disorders, psychological factors play an important role in the development and progression of these diseases. The objective of the present study was to evaluate the impact of psychotherapy on the oral health-related quality of life, pain intensity, and treatment completion in patients with temporomandibular disorders. A total of 53 patients (aged 49.0±10.1) with temporomandibular disorders and moderate to high anxiety level participated in this non-randomized clinical study. Patients who agreed to undergo psychotherapy were included in the study group (n=36), while the others were included in the comparison group (n=17). The group with psychotherapy showed a significantly greater decrease in reactive anxiety, pain intensity, and a significantly greater improvement in oral health-related quality of life (total score and scores for physical pain, psychological discomfort, and psycholodical limitation) compared with the group without psychological treatment. The complex treatment including dental treatment and psychotherapy in patients with temporomandibular disorders and anxiety provided higher treatment success than dental treatment alone. In the psychotherapy group, 83% of patients completed treatment fully (11%) or partially (72%), while 59%of patients in the comparison group dropped out before significant improvement was achieved.
A long-term follow-up of observation in treatment-free remission in patients with chronic myeloid leukemia
Authors: Petrova A. N. , Chelysheva E. Yu. , Nemchenko I. S. , Bykova A. V. , Gurianova M. A. , Kuzmina E. A. , Tsyba N. N. , Kokhno A. V. , Turkina A. G.
Published: May 2023

Introduction. The option of observation without therapy with tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) patients is already included in Russian and international clinical guidelines. Evaluation of long-term follow-up results of treatment free remission (TFR) in CML patients is relevant for the introduction of this approach into routine clinical practice.   Aim — to demonstrate the outcomes in a long-term follow-up of CML patients who discontinued TKI therapy in the RU-SKI trial.   Patients and methods. The prospective study included 98 CML patients with TKI therapy duration ≥ 3 years and a deep molecular response (DMR, BCR::ABL1 ≤ 0.01 %) duration ≥ 2 years. TKI therapy was resumed with the loss of a major MR (MMR, BCR::ABL1 > 0,1 %).   Results. Median time of follow-up after TKI discontinuation was 64 months (range of 51–86 months). Survival without MMR loss at 3 and 5 years after TKI discontinuation was 51 % (CI 41–61 %) and 46 % (CI 36–57 %) respectively. From 3 to 5 years of follow-up without therapy, the loss of MMR occurred in 2 (4 %) patients. There was no MMR loss observed after 5 years of follow-up. In patients with first and second treatment discontinuation, survival without MMR loss was 50 % versus 12,5 %(р = 0,039). All 50 patients with molecular relapses regained MMR and MR4 after TKI therapy resumption. BCR::ABL1 level fluctuations 0,01–0,1 % were in 62 % (n = 29) patients, who were in TFR at the time of analysis. Loss of MR4 was observed in 38 (42 %) from 90 patients with first TKI discontinuation. Survival without MMR loss from MO4 loss was 24 % at 5 years after TKI discontinuation. Loss of MO4 in the first 3 months after TKI cessation was associated with a high probability of further MMR loss (8 % versus 54 % in patients with loss of MO4 for > 3 months, p = 0.00015).   Conclusion. The low frequency of late relapses (4 % after 3 years of follow-up) and the possibility of long-term persistence of minimal residual disease (MRD) after discontinuation of therapy determine the need to optimize the timing of molecular monitoring, taking into account the MRD status of patients.
Thromboelastometry for predicting hemostasis disorders after cardiopulmonary bypass during cardiac surgery
Authors: Akselrod B. A. , Dymova O. V. , Guskov D. A. , Goncharova A. V. , Gladysheva V. G. , Tolstova I. A. , Linnik D. V.
Published: May 2023

Introduction. Assessment of the state of the hemostasis system in cardioanesthesiology is carried out both clinically and using standard laboratory tests — thromboelastography (TEG), rotational thromboelastometry (ROTEM), or a combination of both. Both TEG and ROTEM are designed to detect disorders in the hemostasis system in real time.   Aim – to evaluate the informativeness of ROTEM performed at the stage of cardiopulmonary bypass (CPB) before neutralization of heparin with protamine and to study the prognostic value of this study in assessing the risk of postoperative bleeding during cardiac surgery with a high risk of bleeding.   Materials and methods. The assessment of the diagnostic significance of ROTEM studies at the CPB stage is based on the observation of 31 patients operated on from July to October 2018. The median age of these patients was 55 years (31–72 years). The criteria for inclusion of patients in the study were the performance of planned cardiac surgery with a high risk of bleeding: operations on the aorta, combined operations (coronary bypass surgery and/or surgery on the valve(s), multivalve correction), including repeated. Methods of descriptive statistics, correlation and comparative analyses, and ROC-analysis were used to assess the diagnostic and prognostic capabilities of ROTEM research during CPB against the back=-ground of high doses of heparin.   Results. A statistically significant linear correlation was noted between A5 and MCF indicators in EXTEM, FIBTEM and PLTEM tests performed both during and after CPB. The results obtained indicate that determining the cause of bleeding and deciding on the choice of therapy is possible significantly earlier than the MCF indicator is determined, namely 5 minutes after the start of blood clotting in the ROTEM study. The informative value of ROTEM studies performed during CPB is shown, however, when interpreting the results, it is necessary to focus not only on the reference intervals, but also on the obtained cut-off levels for ROTEM parameters during CPB for early detection of hypofibrinogenemia or thrombocytopenia after CPB.   Conclusion. ROTEM performed with the use of high doses of heparin during CPB is informative for the choice of pathogenetically justified therapy for possible bleeding.
The incidence of impaired binding capacity of von Willebrand factor to collagen types I and III in patients with type 1 von Willebrand disease
Authors: Koloskov A. V. , Vasileva M. Yu. , Philippova O. I. , Chernova E. V. , Beliaeva E. L. , Marchenko V. N.
Published: May 2023

Introduction. Along with the quantitative characteristics of the von Willebrand factor (vWF), more attention is paid to its qualitative characteristics in patients with von Willebrand disease (vWD).   Aim — to evaluate the frequency of vWF binding capacity disorders with type I collagen (vWF:CBAI) and type III collagen (vWF:CBAIII) in patients diagnosed with type 1 vWD and the diagnostic capabilities of these tests.   Material and methods. The prospective study included 224 female patients with previously diagnosed vWD type 1. The following tests were performed in the venous blood sample: von Willebrand factor antigen (vWF:Ag), vWF:CBAI, vWF:CBAIII. The control group consisted of 80 healthy female blood donors.   Results. In the control group, the values of vWF:CBAI and vWF:CBAIII did not exceed the reference intervals. A decrease in vWF:CBAI was detected in 133 (59.4 %) patients and vWF:CBAIII in 26 (11.6 %) patients. An isolated decrease in vWF:CBAI was detected in 87 (38.8 %) patients . An isolated decrease in vWF:CBAIII was less common — in 6 (2.7 %) patients.   Conclusion. The study of vWF:CBAI and vWF:CBAIII appears to be useful as an additional diagnostic test to improve the distinction between healthy individuals and those with VWD.
Immunoglobulin genes and stereotyped antigenic receptors in chronic lymphocytic leukemia and other lymphoproliferative diseases
Authors: Biderman B. V. , Sudarikov A. B.
Published: May 2023

Introduction. The mutational status of immunoglobulin heavy chain variable region genes (IGHV) is the most important prognostic factor in chronic lymphocytic leukemia (CLL). Furthermore, a significant narrowing of the IGHV gene repertoire is found in CLL and other lymphoproliferative diseases.   Aim — to review the publication data on the IGHV genes repertoire and mutational status in CLL and other lymphoproliferative diseases regarding their clinical significance.   General information. Nucleotide sequence of rearranged IGHV genes is a unique marker of a tumor clone. CLL patients with unmutated IGHV genes have an extremely unfavorable disease outcome in contrast to the patients with mutated IGHV genes. Patients with mutated IGHV genes benefit from conventional immunochemotherapy, while non-mutated IGHV patients require therapy escalation with new targeted drugs. The study of IGHV genes and stereotyped antigen receptors repertoire makes possible to identify additional groups of CLL patients with specific genetic and clinical features. Stereotype receptors are also detected in other lymphoproliferative diseases, but their clinical significance has not yet been defined. However, stereotyped receptors are found to be disease-specific.
Incidence and mortality rates of tumors of the hematopoietic and lymphoid tissues in a cohort of workers chronically exposed to ionizing radiation
Authors: Azizova T. V. , Bragin E. V. , Bannikova M. V. , Grigoryeva E. S. , Korobkin A. V.
Published: May 2023

Introduction. Individuals acutely exposed to ionizing radiation demonstrated an increased risk of incidence of malignant neoplasms of the hematopoietic and lymphoid tissues (HLTT). Meanwhile papers describing the impact of chronic radiation exposure on the hematopoietic system are sparse.Aim — to assess incidence and mortality rates for HLTT in a cohort of workers exposed to chronic, occupational ionizing radiation.   Materials and methods. Incidence and mortality rates of HLTT were assessed for workers of a nuclear industrial enterprise who had been hired at the facility from 1948–1982 and followed up until the end of 2018 (22,377 workers). All workers of the study cohort were externally and/or internally exposed to ionizing radiation during occupational industrial activities. In the studied cohort of workers, 186 cases and 123 deaths (as a main cause) from HLTT were registered throughout the entire follow-up period (1948–2018).   Results. Crude incidence and mortality rates of HLTT in workers of the study cohort were associated with sex, attained age of workers and calendar follow-up period. Standardized incidence and mortality rates for males were significantly higher compared to females. The standardized HLTT incidence rates (per 1000 person-years of observation) were 0.36 ± 0.03 in males and 0.23 ± 0.04 in females while the standardized HLTT mortality rates were 0.16 ± 0.02 in males and 0.09 ± 0.02 in females.   Conclusions. The study revealed significant increasing trends for incidence rates of chronic leukemia and lymphoma by the end of the follow-up period (31. 12. 2018).
Total knee arthroplasty in a female with a severe form of hemophilia A
Authors: Zorenko V. Yu. , Koroleva A. A. , Polyanskaya T. Yu. , Karpov E. E. , Pshenichnikova O. S. , Surin V. L.
Published: May 2023

Introduction. Hemophilia is an X-linked hereditary blood clotting disorder caused by insufficiency of blood clotting factor VIII or IX that affects mainly men. In extremely rare cases, the disease can be observed in women, which is most often associated with asymmetric inactivation of the X chromosome. The severity of hemophilia in women does not differ from that in men.   Aim – to present a clinical observation of surgical treatment of stage 4 hemophilic arthropathy in a woman with severe hemophilia A.   Main findings. Female patient T., 39 years old, was admitted to the National Medical Research Center for Hematology with a preliminary diagnosis: hereditary deficiency of factor VIII. She had an extension of the APTT to 68.8 sec, a high level of Willebrand factor activity — 222 %, and the concentration of Willebrand factor antigen of 178.1 mg/l, and a decrease in the level of factor VIII to 1.6 %. According to molecular genetic analysis, intron 22 inversion associated with severe hemophilia A was detected in the F8 gene. Throughout the patient’s life, hemarthrosis of the knee, ankle and elbow joints were observed, which led to the development of severe arthropathy of varying severity. The woman underwent total knee arthroplasty and arthrolysis of the left ankle joint. The postoperative period proceeded without complications. Hemostatic replacement therapy was performed with a recombinant factor VIII.
Platelet Delta granules storage pool deficiency in female patient with severe hemorrhagic syndrome
Authors: Kosheed I. V. , Mamaev A. N. , Motin Y. G. , Kudinov A. V. , Momot A. P. , Babaeva T. N.
Published: May 2023

Introduction. Platelet dense granule disorders are a group of rare heterogeneous disorders of the blood coagulation system in which bleeding occurs due to functional and morphological disorders of platelet organelles accumulating phosphates and bioactive amines.   Aim — to present a clinical case of a 37-year-old patient with severe hemorrhagic syndrome.   Basic information. An observation of the occurrence of hemorrhagic manifestations of unspecified genesis in a patient is described. The results of 25 healthy volunteer examinations of both sexes were used as a control for testing methods of diagnosis of Platelet dense granule disorder. Methods of assessing the hemostasis system, platelet morphological features using electron microscopy, as well as platelet accumulation of mepacrine using a flow cytometer were studied. Platelet dense granule disorder was detected by electron microscopy and confirmed by flow cytometry in a patient with severe hemorrhagic manifestations, in whom the diagnosis was not verified for a prolonged period of time.
Sosialisasi Peranan Lembaga Adat dalam Menyelesaikan Pelanggaran Adat di Kaseupahan Sinar Resmi Kabupaten Sukabumi
Authors: Pratiwi Seli Septiana , Rozakiyah Desy Santi , Meiji Nanda Harda Pratama , Apriadi Deny Wahyu
Published: May 2023

Local and foreign tourists can be persuaded to visit attractions offered through social media. Wonokitri Village, one of the gateways to Bromo Tengger Semeru National Park (TNBTS), has resumed tourism promotion through social media. There are barriers to managing social media, including owning and managing social media. The charity will be implemented through outreach and direct support to village youth by involving Pokdarwis Wonokitri Village as a participant. The goal is to make village promotions more inclusive and allow local communities to manage social media to attract tourists. Philanthropic activities include direct participatory efforts. The first step in maximizing our work was to work with POKDARWIS members to identify the key constraints and needs of the local community. Next, a discussion was held on the content that characterizes the village's potential. In addition, local village youth are supported to create engaging social media content for tourists, especially in the form of photographs. The implementation team also gained an understanding of the different functions of social media used and how to best utilize them to promote digital village tourism.
Sosialisasi Peranan Lembaga Adat dalam Menyelesaikan Pelanggaran Adat di Kaseupahan Sinar Resmi Kabupaten Sukabumi
Authors: Priyana Puti , Gunawan Tanumihardja Jopie , Pratiwi Wienike Dinar
Published: May 2023

Kaseuphan Sinar Official adopts the common law style, showing the usual characteristics of the common law community itself. Issues of violations and incidents affect not only modern nations, but also indigenous peoples as well as areas of social service. There is a moral system that acts as a countermeasure and as a place to settle violations. Communities that are Target Partners of Community Service should facilitate the role of traditional institutions and resolution of common cases in ​​Target Partners of Community Service so that future Target Partners of Community Service can take advantage of traditional institutions. It is expected that you will understand and be able to understand. It is suitable for the courts of the Indonesian state. And beyond that, in disputes involving children or within the framework of common law. It is hoped that eligible community service partners will be able to learn more about how to handle common cases involving children. Additionally, even after socialization and modules, the community expected that target partners of her services have knowledge of child protection law (such as rights and responsibilities) as an integral part of the target partner environment of the service. will be as a result, we found that the targeted community service partners were very enthusiastic about carrying out this activity, which was reflected in the various questions posed to the resource personnel. This community service provides an overview of the community services team working to maximize the role of traditional institutions in Karawang Regency's Sinar Official Village and reduce the number of child protection violations in the area.
ANALISIS PERBEDAAN VERBA DIALEK SIKKA NATAR DAN DIALEK TANA AI DALAM BAHASA SIKKA
Authors: Maria Olivia  , Maria E. D. Lering  , Rimasi  , Antonius M. K. Naro
Published: May 2023

The purpose of this study aims  at analysing the differences of verbs between the Sika and the Tana Ai dialects. This is a qualitative descriptive research to describe objectively and accurately. The subjects were 14 people of Sika Natar Hamlet in sika village and Pauklor Hamlet in Pruda village, 7 from each village respectively. The seven informants consist of 1 expert informant and 6 ordinary informants. Data were analyzed using the equivalent method. The results of data analysis based on the and interview and listening during the conversations between the researcher and the informants proved that there are pairs of different verbas with different phonemes in the initial, middle and final consonant sounds. Then, from the pair of consonants and vowels sounds, were also found.
PENGARUH KEPUASAN KERJA AUDITOR, PENGALAMAN DAN PROFESIONALISME TERHADAP KUALITAS AUDIT
Authors: Shannen Yucta  , Hisar Pangaribuan
Published: May 2023

This study was conducted to determine the effect of auditor job satisfaction, experience, and professionalism on audit quality in public accounting firms in Jakarta. This study uses primary data in the form of answers from respondents to questionnaire data collection. This study uses a purposive sampling method in determining the sample and 63 samples have met the criteria. This study uses multiple linear regression analysis in the data analysis technique, where the results of this study indicate that the experience and professionalism variables affect audit quality, while the auditor's job satisfaction variable does not affect audit quality.
PENGARUH PROFITABILITAS DAN INTENSITAS MODAL TERHADAP AGRESIVITAS PAJAK PADA PERUSAHAAN PERTAMBANGAN BATU BARA YANG TERDAFTAR DI BEI PADA TAHUN 2018-2021
Authors: Elma Rebecca Tania Simanjuntak  , Lorina Siregar Sudjiman
Published: May 2023

The phenomenon of the issuer of a new coal mining company, PT Bukit Asam Tbk, recorded a decline in performance, even though world coal prices were on an upward trend. This caused PTBA's shares to drop 22% to Rp. 3.99 compared to last year's Rp. 5.12 trillion. In addition, the cost of revenue also fell to Rp. 2.97 trillion last year amounting to Rp. 3.59 trillion. This study wants to determine the effect of profitability and capital intensity on tax aggressiveness in coal mining companies listed on the Indonesia Stock Exchange in 2018-2021. The research method uses a quantitative approach using secondary data. The research population is all coal mining companies listed on the IDX in 2018-2021, using purposive sampling technique, data analysis using multiple linear regression analysis with the IBM SPSS program analysis tool version 22. The results show that partially profitability has a significant effect on tax aggressiveness, intensity capital has a significant effect on tax aggressiveness, while simultaneously profitability and capital intensity have a significant effect on tax aggressiveness in 24 coal mining companies listed on the IDX in 2018-2020.
PENGARUH PENERAPAN KEBIJAKAN PROGRAM PENGUNGKAPAN SUKARELA (PPS) / TAX AMNESTY JILID II DAN SANKSI PAJAK TERHADAP KEPATUHAN WAJIB PAJAK
Authors: Clarina Freshya Waruwu  , Lorina Siregar Sudjiman
Published: May 2023

The purpose of this research  is to determine the effect of the Voluntary Disclosure Program and tax sanctions on taxpayer compliance. This research used 37 respondent taxpayers from various regions. The data collection method for this research is the questionnaire method, which is distributed online with google forms on a likert scale of 1-5 points and processed using SPSS application. Data analysis techniques include descriptive statistical, validity test, reliability test, coefficient of determination test (Adjusted R Square), simple linear test and correlation coefficient test. The results of the study indicate that the Voluntary Disclosure Program has a significant effect on taxpayer compliance and tax sanctions had no effect on taxpayers.
ETIKA DALAM PANDANGAN IBN KHALDUN
Authors: Mohamad Iqbal Paudi
Published: May 2023

Ibn Khaldun was a leading Muslim scholar in his time.  We can read the level of knowledge and examine the works he has written which are still the main reading material in various scientific aspects.  A life full of political intrigue made him learn a lot from the matter of moral and ethical power.  He is a scholar who is so obedient to Islam, this can be seen from his thoughts which become Islamic law in this case the Qur'an and Hadith as hujjah arguments, as well as his thoughts on ethics.  This study aims to see the relevance of Ibn Khaldun's ethical view as a special view.  This research is a library research (Library Research).  The data collection of this research is by doing documentation, then data analysis by using descriptive-analytic method.  The results of this study are, according to Ibn Khaldun, religion is the main source of ethics, religion through its teachings and laws teaches humans about noble moral values ​​such as fairness, honesty, and so on.  The teachings of the morality of the hadith religion in all aspects of life such as political economy and education, all of which are basically aimed at creating a good life.
PENGARUH PROFESIONALISME AUDITOR TERHADAP TINGKAT MATERIALITAS DALAM PEMERIKSAAN LAPORAN KEUANGAN
Authors: Violyta Rophinta , Sudjiman Lorina Siregar
Published: May 2023

This study aims to see and determine the effect of Auditor Professionalism on the Materiality Level in the Examination of Financial Statements. the method used by the author is quantitative. With 52 auditors as a sample of 6 accounting firms. The technique used in this study is the multicollinearity test technique, autocorrelation test, standard probability plot test, T-test, and F test. The survey results reveal a significant effect of Auditor Professionalism on the Materiality Level in the Examination of Financial Statements.
PENGARUH PROFITABILITAS, SOLVABILITAS DAN UKURAN PERUSAHAAN TERHADAP AUDIT REPORT LAG PADA PERUSAHAAN MAKANAN DAN MINUMAN YANG TERDAFTAR DI BEI PERIODE 2019–2021
Authors: Simanungkalit Aditya Fredrik , Sudjiman Lorina Siregar
Published: May 2023

Tujuan Penelitian adalah untuk melihat dan mengetahui pengaruh dari profitabilitas, solvabilitas dan ukuran perusahaan terhadap audit report lag pada Perusahaan Makanan dan Minuman yang Terdaftar di BEI Periode 2019–2021. penelitian ini memakai metode kuantitatif, sampel yang dipakai sebanyak 19 perusahaan dengan memakai metode purpose sampling yang berjumlah 57 data. tekhnik yang dipakai pada penelitian ini adalah tekhnik statistik deskripsi, uji hipotesis, uji koefisien determinasi, uji asumsi klasik dan juga regresi linear berganda. hasil penelitian mengungkapkan adanya pengaruh yang signifikan dari profitabilitas, solvabilitas dan ukuran perusahaan terhadap audit report lag pada Perusahaan Makanan dan Minuman yang Terdaftar di BEI Periode 2019–2021.
PENGARUH PENJUALAN, BIAYA OPERASIONAL DAN BIAYA KEUANGAN TERHADAP LABA BERSIH PERUSAHAAN PADA PERUSAHAAN SUB SEKTOR MAKANAN DAN MINUMAN YANG TERDAFTAR DI BEI PERIODE 2019-2021
Authors: Sibuea Alfiano Marcellino , Siagian Harlyn
Published: May 2023

Pada penelitian ini dilakukan sebagai pengujian antara pengaruh penjualan, biaya operasional, biaya keuangan terhadap laba bersih perusahaan dengan sub-sektor makanan dan minuman yang tercatat di Bursa Efek Indonesia pada periode 2019-2021. Populasi pada penelitian ini berjumlah 20 perusahaan dengan periode 3 tahun sehingga sampel nya sebanyak 60 data. Penelitian menggunakan spss 26 sebagai alat uji statistik. Hasil pada penelitian menunjukkan bahwa penjualan berpengaruh positif terhadap laba bersih perusahaan, sementara biaya operasional dan biaya keuangan tidak berpengaruh signifikan terhadap laba bersih. Tetapi secara simultan penjualan, biaya operasional dan biaya keuangan terhadap laba bersih memiliki hubungan signifikan positif
EFEKTIVITAS PENGGUNAAN MINYAK AROMATERAPI LAVENDER (Lavandula angustifolia) DALAM PENURUNAN TEKANAN DARAH PADA HIPERTENSI
Authors: Dewi Putu Ita Purnama , Astuti Ketut Widyani
Published: May 2023

Hipertensi merupakan peningkatan tekanan darah baik diastolik maupun sistolik secara hilang timbul atau menetap. Hipertensi dapat terjadi secara esensial (primer atau idiopatik) dimana faktor penyebabnya tidak dapat diidentifikasi, atau secara sekunder, akibat dari penyakit tertentu yang diderita. Salah satu terapi yang dapat menurunkan hipertensi yaitu aromaterapi. Aromaterapi merupakan salah satu pengobatan komplementer yang menggunakan minyak esensial sebagai agen terapi utama. Salah satu tanaman yang dapat dijadikan sebagai aromaterapi adalah bunga lavender (Lavandula angustifolia). Aromaterapi lavender merupakan suatu cara perawatan tubuh atau penyembuhan dengan menggunakan minyak esensial. Aromaterapi lavender bekerja dengan mempengaruhi fisik dan juga emosi. Tujuan dari review artikel ini  untuk mengetahui penggunaan aroma terapi lavender (Lavandula angustifolia) pada penurunan hipertensi. Metode yang digunakan dalam pembuatan artikel review ini yaitu studi pustaka. Pustaka yang digunakan merupakan jurnal nasional maupun internasional yang membahas mengenai penggunaan aroma terapi lavender pada hipertensi yang diterbitkan secara online dari berbagai situs seperti Google Scholar, Science Direct, Researchgate, Pubmed, dan Springerlink dengan menggunakan kata kunci aromaterapi lavender dan hipertensi. Kesimpulan pada review artikel ini Berdasarkan hasil analisis beberapa artikel bahwa penggunaan aromaterapi lavender sebagai relaksasi efektif menurunkan tekanan darah atau hipertensi secara signifikan.
UPAYA MENINGKATKAN KOMPETENSI GURU PAI DALAM PENYUSUNAN RPP YANG BAIK DAN BENAR MELALUI PENDAMPINGAN BERBASIS KKG KECAMATAN SEMESTER DUA DI KKG PAI KECAMATAN SELAPARANG KOTA MATARAM TAHUN PELAJARAN 2019/2020”
Authors: H. Muksin
Published: May 2023

Latar belakang diadakannya Penelitian ini adalah rendahnya kompetensi guru sasaran Di KKG PAI Kecamatan Selaparang Kota Mataram dalam penyusunan Rencana Pelaksanaan Pembelajaran (RPP) yang baik dan benar yang berdampak kurang percaya diri dalam proses pembelajaran. Solusinya diadakan pendampingan baik secara kelompok maupun individu dalam penyusunan RPP yang baik dan benar. Tujuannya adalah untuk mengetahui efektifitas pelaksanaan pendampingan berbasis KKG dalam upaya meningkatkan kompetensi guru dalam menyusun RPP yang baik dan benar, yang bermanfaat untuk meningkatkan profesionalisme sebagai pengawas sekolah dan bagi guru untuk meningkatkan proses pembelajaran di kelas. Hipotesis tindakan: meningkatkan kompetensi guru sasaranyang di pusatkan di SD Negeri 6 MataramSemester DuaTahun Pelajaran 2017/2018 dalam menyusun RPP yang baik dan benar. Penelitian ini dilaksanakan sebanyak dua siklus, masing-masing siklus dua kali pertemuan. Tahapan setiap siklus adalah perencanaan, pelaksanaan, pengamatan, dan refleksi. Indikator keberhasilan dalam penelitian ini adalah; 1) hasil observasi Pengawas Sekolah maupun observasi guru selama proses pendampingan telah memperoleh skor rata-rata > 4,0, 2)hasil kerja guru dalam penyusunan RPP mencapai > 85% dengan nilai rata-rata > 80,00. Hasil penelitian pada siklus I observasi Pengawas Sekolah rata-rata (3,40), observasi guru rata-rata (3,20) dan hasil kerja individual rata-rata nilai (72,62) dengan prosentase ketercapaian (0%). Pada siklus II observasi Pengawas Sekolah rata-rata (4,40), observasi guru rata-rata (4,50) dan hasil kerja individual rata-rata nilai (85,39) dengan prosentase ketercapaian (100%). Indikator keberhasilan telah tercapai, penelitian di nyatakan berhasil dan dihentikan pada siklus II. Kesimpulan; pelaksanaan pendampingan dapat meningkatkan kompetensi guru sasaran di KKG PAI Kecamatan SelaparangKota mataram dalam penyusunan RPP yang baik dan benar. Disarankan agar pengawas lainnya melakukan penelitian sejenis dalam upaya peningkatan kompetensi guru, dan kepada guru mata pelajaran agar mampu menyusun RPP dengan baik dan benar.
Review Pemilihan Adsorben Pada Proses Bleaching Dalam Metode Pemurnian Minyak Ikan
Authors: Tanaya Cokorda Andi Janawi , Astuti Ni Made Widi
Published: May 2023

Bleaching is one of the processes in fish oil purification methods. In the bleaching process, it is necessary to use an adsorbent in the form of bleaching earth. This review article aims to review the various adsorbents that are most often used in fish oil purification methods. The review method in this article uses searches with search engines such as Google Scholar and Pubmed. Based on the search found below, there are several types of adsorbents that are most often used for the bleaching process in refining fish oil, namely Bentonite (Activated Charcoal), Magnesol XL, and Zeolite. Based on the three adsorbents found, each type has advantages and disadvantages which depend on the method used, temperature, speed and duration of centrifugation in the bleaching process.