bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcleral fixation of IOL as an optimal barrier between the chambers of the eye in vitreal pathology
Authors:   FSBI NMHC named after N.I. Pirogov of the Ministry of Health of Russia, Moscow, Karpov G.O. , Bosov E.D. ,   FSBI NMHC named after N.I. Pirogov of the Ministry of Health of Russia, Moscow, Kalinin M.E. ,   FSBI NMHC named after N.I. Pirogov of the Ministry of Health of Russia, Moscow, Martynov А.О. ,   FSBI NMHC named after N.I. Pirogov of the Ministry of Health of Russia, Moscow
Published: June 2024

In case of regmatogenic retinal detachment, the main point is the formation of a strong barrier between the chambers of the eye using intraocular lenses, including in case of combined pathology, and in particular in the absence of the possibility of implanting a lens into the capsular bag. The distinctive features of the lens location relative to the limb and cornea were identified during a comparative analysis of the position of intraocular lenses in patients with articulation and transcleral fixation using optical coherence tomography. The purpose of the study was to conduct a comparative analysis of the position of intraocular lenses in patients with transcleral fixation and in patients with artificial in the conditions of silicone tamponade of the vitreal cavity. Material and methods. The studies were carried out on 64 eyes of patients aged 56 to 75 years with transcleral fixation and artifaction with silicone tamponade of the vitreal cavity. Results. In patients with transcleral fixation, the distance from the limb to the optical edge of the lens was equal to 4.31 ± 0.82 mm, in the group with articulation 4.11 ± 1.03 mm. The absence of a statistically significant difference indicates the position of the intraocular lens when performing transcleral fixation identical to the location of the lens in the capsule bag. The indicator of the distance from the cornea to the edge of the intraocular lens in patients with transcleral fixation corresponded to 3.72 ± 1.54 mm, in patients with articulation corresponded to 3.21 ± 1.48 mm, while this indicator in the group with transcleral fixation was more variable. Conclusion. In the conditions of silicone tamponade of the vitreal cavity, the technique of transcleral fixation of intraocular lenses provides a single-format position of the lens with artificial patients. Keywords: intraocular lens, transcleral fixation, silicone tamponade
Results of autotranslocation of pigment epithelium — choroid graft within one year
Authors:   The S. Fyodorov foundation to promote the development of advanced medical technology, Moscow, Kutin I.M. , Mironov A.V. ,   The S. Fyodorov foundation to promote the development of advanced medical technology, Moscow, Magaryan T.O. ,   The S. Fyodorov foundation to promote the development of advanced medical technology, Moscow, Zakharchuk A.V. ,   The S. Fyodorov foundation to promote the development of advanced medical technology, Moscow, Murtazalieva F.T. ,   The S. Fyodorov foundation to promote the development of advanced medical technology, Moscow
Published: June 2024

Purpose. Present the results of transplantation of the retinal pigment epithelium — choroid complex, dynamic observation for 12 months. Material and methods. Retrospective analysis of surgical treatment of 14 patients with autologous translocation of the pigment epithelium (PES) — choroid graft due to the presence of submacular pathology, namely: atrophy of the pigment epithelium, submacular hemorrhage, subretinal fibrosis. Results. In all cases, within 12 months, best-corrected visual acuity (BCVA) exceeded preoperative values and had positive dynamics throughout the entire observation period. Conclusions. Translocation of the autologous pigment epithelium-vascular complex represents a possible treatment option for neovascular AMD when standard methods are ineffective. Keywords: macular translocation, age-related macular degeneration
Сlinical case of penetrating wound of the eyeball with intraocular foreign body
Authors:   State Autonomous Healthcare Institution Orenburg Regional Clinical Hospital named after V.I. Voynov, Orenburg, Laskova I.V. , Kravchenko A.A. ,   State Autonomous Healthcare Institution Orenburg Regional Clinical Hospital named after V.I. Voynov, Orenburg, Naidenova S.I. ,   State Autonomous Healthcare Institution Orenburg Regional Clinical Hospital named after V.I. Voynov, Orenburg, Uskov D.I. ,   State Autonomous Healthcare Institution Orenburg Regional Clinical Hospital named after V.I. Voynov, Orenburg, Vidrevich S.E. ,   Federal State Budgetary Educational Institution of Higher Education Orenburg State Medical University, Orenburg
Published: June 2024

Today, injuries to the eyeball are the most common cause of visual impairment in people of working age. Perforated wounds of the eyeball are the most severe of all injuries, especially in combination with an intraocular foreign body. Purpose. To evaluate the effectiveness of organizing surgical care for a patient with a penetrating eyeball with an intraocular foreign body. Material and methods. Clinical example. Patient K., 38 years old, complained of decreased visual acuity in the right eye. The patient could not cope without outside help. From the anamnesis: five months ago he was injured (mine-explosive injury). He received conservative therapy in another clinic. Subsequently, he did not receive any surgical ophthalmological treatment. Vision decreased gradually. Left eye with a penetrating wound from 2016. Complex surgical treatment was performed. Results. As a result of combined surgical treatment, social rehabilitation of a patient of working age was achieved. Conclusions. High-tech medical care for patients with penetrating wounds of the eyeball should be provided to the maximum extent, which allows to shorten the rehabilitation period, speed up recovery and obtain a high functional result. Keywords: eyeball, penetrating injury, intraocular foreign body, vitreoretinal surgery
Femtosecond terahertz pulse propagation measurements and simulations of dewetting kinetics in real time
Authors: NOME RENE , Silva Helen , Rohwedder Jarbas
Published: June 2024

We report a terahertz time-domain study of dewetting kinetics on two time scales, femtoseconds and in real time (on the order of minutes). We have recorded full electric field terahertz time domain signals with femtosecond time resolution during dewetting of water in cellulose. The femtosecond time-domain signals were analyzed with respect to the amplitude and signal emission times, and how these two quantities changed over the course of dewetting kinetics. The femtosecond time-domain signals were modeled by a combination of finite-difference time-domain electromagnetic simulations of linear terahertz pulse propagation and an effective medium description of the dielectric permittivity. A logistic regression mechanism was incorporated in the electrodynamics simulations to account for the observed kinetics. In addition, analysis of the area-normalized, real-time time-dependent terahertz spectra were used to identify broad regions in the terahertz spectral range that correlated with the kinetic process. Real-time two-dimensional terahertz correlation maps were used to identify the pure rotational spectrum of water vapor, thus characterizing the evaporation part of the dewetting kinetics problem. We conclude with a kinetic model that accounts for our observations through a microscopic mechanism involving the interconversion between bulk water, water clusters, and individual water molecules in the gas phase. Overall, the approach presented here illustrates an application of femtosecond time-resolved experiments in the terahertz spectral range to the study of kinetic processes.
Alpha-Ammonium Carbamates Undergo Efficient Two-Step Linker Cleavage and Improve the Properties of Antibody Conjugates
Authors: Li Xiaoyi , Patel Nimit , Kalen Joseph , Schnermann Martin
Published: June 2024

Targeted payload delivery strategies, such as antibody-drug conjugates (ADCs), have emerged as useful therapeutics. Although considerable efforts have been made in the areas of antibody engineering and labeling methodology, improving the overall physicochemical properties of the linker/payload combination remains an important challenge. Here we report an approach to create an intrinsically polar linker domain. We find that -ammonium carbamates (AAC) undergo a tandem 1,6–1,2 elimination sequence to release secondary amines. Using a fluorogenic hemicyanine as a model payload component, we show that a zwitterionic AAC linker improves labeling efficiency and reduces antibody aggregation when compared to a commonly used Val-Ala linker as well as a cationic AAC. Cellular and in vivo fluorescence imaging studies demonstrate that the model payload is released in antigen-expressing cells and tumors with high specificity. Broadly, this strategy may provide a general approach to mask the hydrophobicity of payloads and improve the properties of targeted agents.
Reference-Free Thio-Succinimide Isomerization Characterization by Electron-Activated Dissociation
Authors: Yang Junyan , Yuan Jiaqi , Huang Yue , Rosenbaum Anton
Published: June 2024

Rationale Isomerism can be an important aspect in pharmaceutical drug development. Identification of isomers can provide insights into drug pharmacology and contribute to better design of drug molecules. The general approaches to differentiate isomers include Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and circular dichroism. Although proven effective, a commonly used method to differentiate isomers is chromatography coupled with mass spectrometry (MS). Notably, MS is routinely applied in leucine and isoleucine differentiation to facilitate protein sequencing. This work focuses on isomer differentiation of widely applied thio-succinimide structure bridging the antibody backbone and linker-payload of antibody-drug conjugates (ADCs). The hydrolysis of thio-succinimide stabilizes the payload-protein structure while generating a pair of constitutional isomers: thio-aspartyl and thio-isoaspartyl. Methods This paper introduces a hybrid method using ligand binding assay (LBA) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) to reveal isomerization details of thio-succinimide hydrolysis over time in plasma samples incubated with ADC. By applying two orthogonal fragmentation methods, collision-induced dissociation (CID) and electron-activated dissociation (EAD), this pair of isomers showed different MS/MS spectra. This observation enables a unique approach in distinguishing thio-succinimide hydrolysis isomers. Results We observed signature c+57, z-57 and z-44 fragment ions that differentiated thio-aspartyl and thio-isoaspartyl isomers using EAD. A newly discovered z-12 ion also served as additional evidence that further supported our findings. Conclusions This study is a first-to-date identification of thio-succinimide hydrolysis isomers without using synthesized reference materials. This approach should be applicable to all thio-succinimide-linked molecules. Correct identification of thio-succinimide hydrolysis isomers may eventually benefit the development of ADCs in the future.
Catalytic Reductive Homocoupling of Benzyl Chlorides Enabled by Zirconocene and Photoredox Catalysis
Authors: Tajima Ryota , Tanaka Keisuke , Aida Kazuhiro , Ota Eisuke , Yamaguchi Junichiro
Published: June 2024

The bibenzyl skeleton is prevalent in numerous natural products and other biologically active compounds. Radical homocoupling provides a straightforward approach for synthesizing bibenzyls in a single step, with the reductive homocoupling of benzyl halides undergoing extensive development. Unlike benzyl bromides and other tailored pre-cursors used in visible light-mediated homocoupling, benzyl chlorides offer greater abundance and chemical stabil-ity. Nevertheless, achieving chemoselective cleavage of the C–Cl bond poses significant challenges, with only a limited number of studies reported to date. Herein, we demonstrate a catalytic reductive homocoupling of benzyl chlorides facilitated by zirconocene and photoredox catalysis. This cooperative catalytic system promotes C–Cl bond cleavage in benzyl chlorides under mild conditions and supports the homocoupling of a wide range of benzyl chlorides, includ-ing those derived from pharmaceutical agents. Our preliminary mechanistic investigations highlight the pivotal role of hydrosilane in the catalytic cycle.
LSM1-MS2: A Foundation Model for MS/MS, Encompassing Chemical Property Predictions, Search and de novo Generation
Authors: Asher Gabriel , Cadosh Delmar Mimoun , Campbell Jennifer M. , Geremia Jack , Kassis Timothy
Published: June 2024

We present LSM1-MS2, a pre-trained self-supervised foundation model designed for tandem mass spectrometry (MS/MS) utilizing a transformer architecture with custom tokenization for masked MS2 peak reconstruction. Our model is fine-tuned on smaller, labeled datasets for tasks such as compound property prediction, spectral matching, and de novo molecular generation. LSM1-MS2 demonstrates superior performance compared to traditional supervised models, achieving high accuracy with minimal labeled data. It outperforms conventional methods in database lookups and molecular query retrievals and shows promising results in the opening field of de novo molecular generation. The model's efficiency in spectral lookup tasks, with significantly reduced evaluation times, underscores its potential for large-scale applications. Our findings highlight the transformative capability of self-supervised pre-training in enhancing the predictive power of models for mass spectrometry, particularly in data-limited scenarios. The success of LSM1-MS2 in property prediction, database spectral lookup, and molecular generation paves the way for its application in metabolomics and drug discovery, facilitating robust and scalable analysis with reduced data requirements.
Oxidation-Induced Ligand Swap: Oxygen Insertion into a Cobalt-Phosphine Complex
Authors: Katipamula Sriram , Emge Thomas , Waldie Kate
Published: June 2024

The synthesis and characterization of a half-sandwich cobalt(II) complex supported by the bidentate, pendent-amine phosphine ligand (PPh2NBn2 = 1,5-diaza-3,7-diphosphacyclooctane) are reported. Oxidation of a cobalt(I)-phosphine precursor with silver(I) salts yielded the paramagnetic complex [CpCo(PPh2NBn2)]+. This species rapidly reacts with oxygen upon air exposure under ambient conditions, resulting in the insertion of oxygen into the cobalt-phosphine bonds. Two cobalt complexes were generated from this reaction: the cobaltocenium cation, bearing two Cp ligands (Cp = cyclopentadienyl); and a cobalt(II)-bis(phosphine oxide) dicationic complex in which two O2P2N2 ligands coordinate in a fac fashion via two oxygen and one nitrogen centers to establish an overall octahedral geometry. Thus, the aerobic oxidation of the phosphine induces the exchange and rearrangement of the ligands at cobalt.
Interfacial Ice Density Fluctuations Inform Surface Ice-philicity
Authors: Vicars Zachariah , Choi Jeongmoon , Marks Sean , Remsing Richard , Patel Amish
Published: June 2024

The propensity of a surface to nucleate ice or bind to ice is governed by its ice-philicity — its relative preference for ice over liquid water. However, the relationship between the features of a surface and its ice-philicity is not well understood, and for surfaces with chemical or topographical heterogeneity, such as proteins, their ice-philicity is not even well-defined. In the analogous problem of surface hydrophobicity, it has been shown that hydrophobic surfaces display enhanced low water-density (vapor-like) fluctuations in their vicinity. To interrogate whether enhanced ice-like fluctuations are similarly observed near ice-philic surfaces, here we use molecular simulations and enhanced sampling techniques. Using a family of model surfaces for which the wetting coefficient, k, has previously been characterized, we show that the free energy of observing rare interfacial ice-density fluctuations decreases monotonically with increasing k. By utilizing this connection, we investigate a set of fcc systems and find that the (110) surface is more ice-philic than the (111) or (100) surfaces. By additionally analyzing the structure of interfacial ice, we find that all surfaces prefer to bind to the basal plane of ice, and the topographical complementarity of the (110) surface to the basal plane explains its higher ice-philicity. Using enhanced interfacial ice-like fluctuations as a measure of surface ice-philicity, we then characterize the ice-philicity of chemically heterogeneous and topologically complex systems. In particular, we study the spruce budworm anti-freeze protein (sbwAFP), which binds to ice using a known ice-binding site (IBS) and resists engulfment using non-binding sites of the protein (NBSs). We find that the IBS displays enhanced interfacial ice-density fluctuations and is therefore more ice-philic than the two NBSs studied. We also find the two NBSs are similarly ice-phobic. By establishing a connection between interfacial ice-like fluctuations and surface ice-philicity, our findings thus provide a way to characterize the ice-philicity of heterogeneous surfaces.
Association of genotypes of biotransformation enzymes with susceptibility to chronic pulmonary tuberculosis
Authors: Alymenko Maxim A. , Valiev Ravil Sh. , Valiev Nail R. , Balobanova Natalya P. , Batishchev Alexander V. , Tragira Irina N. , Lipatov Viacheslav A. , Polonikov Alexey V. , Kolomiets Vladislav M. , Volkova Svetlana N. , Mal Galina S. , Ragulina Vera A.
Published: June 2024

Background. Now it is well-known that the pulmonary tuberculosis is a multifactorial disease in which forming a certain role belongs as factors external the environment, and genetic to factors.
Aim. In this study, the association of genes of xenobiotic biotransformation enzymes: NAT2 [590GA (rs1799930)], CYP2E1 [9896CG (rs2070676)], ABCB1 [3435TC (rs1045642)], GSTM1 (E/D) and GSTT1 (E/D) with susceptibility to torpid pulmonary tuberculosis was carried out.
Materials and methods. 123 people suffering from torpid pulmonary tuberculosis were included in the study. Genomic DNA was isolated using Arrow Blood DNA 500 reagent kits from whole blood (at the NorDiag Arrow station). Next, the polymerase chain reaction was staged in real time using sets of reagents for SNPs genotyping.
Results. The study showed an association of gene polymorphisms of xenobiotic biotransformation enzymes with susceptibility to torpid pulmonary tuberculosis, including certain clinical forms of pulmonary tuberculosis.
Conclusion. During the conducted research it was established that implementation of results of genotyping of enzymes of biotransformation of xenobiotics in practice of the doctor of the phthisiatrician for the purpose of forming of risk groups of suffering from tuberculosis lungs which have a susceptibility probability to this disease that perhaps in the future will provide the individualized approach to prevention and treatment of these patients is necessary.
The use of combined drugs as a component of complex therapy of inflammatory diseases of the pharynx: A review
Authors: Kosyakov Sergey Ya. , Pchelenok Ekaterina V. , Usmanova Khava S.
Published: June 2024

Unfortunately, the occurrence of various pathologies in the ENT organs still remains one of the pressing problems in global healthcare. The frequent manifestation of unwanted pathologies forces us to change methods, and sometimes to introduce something new into the medical care provided to patients. Researchers from the Center for Medical Statistics of the Scientific Research Institute of Medical Sciences and Medical Research, Moscow Health Department, having conducted a detailed analysis of the activities of otorhinolaryngological departments in medical organizations in the city of Moscow, found that in 2022 the number of all visits to otorhinolaryngologists exceeded 4.5 million, of which 45.7% were children, and 54.2% were committed by persons over 18 years of age. Preventive visits of patients to doctors for 2018–2022 increased from 29.3 to 37.8%. Infectious and inflammatory diseases of the oral cavity and pharynx are among the most common diseases of the ENT organs. Given the proliferation, development of technology and possible tensions, they still remain a pressing issue. That is why various new options for drug therapy are being proposed that would be most effective, and one of these new drugs is Lorothricin, a combination drug that has shown itself to be the best in a number of studies and clinical cases. In a review article, based on our experience and literature data. We present the problem of treating patients with sore throat due to acute pharyngitis, tonsillitis and gingivitis.
Um Aplicativo Android como Recurso Didático para Ensino e Aprendizagem de Ondas Eletromagnéticas
Authors: Soares Francisco das Chagas , Tavares Lira Marcos Antônio , Dos Santos Freitas Moisés José , Alves de Sousa Lima Marcos Antônio
Published: June 2024

Esse trabalho tem como objetivo desenvolver um aplicativo para dispositivos móveis com o sistema operacional Android. Essa pesquisa partiu da seguinte questão: quais as contribuições do uso do aplicativo Android para a melhoria do ensino e do aprendizado dos conteúdos relacionados ao eletromagnetismo? A pesquisa foi fundamentada na teoria de Lev Vygotsky, em especial a mediação. Para o desenvolvimento do aplicativo, foi utilizado o programa Android Studio, que atualmente é a plataforma oficial do Google para esse fim. O publico alvo da pesquisa foram alunos da terceira série do ensino médio regular, no ano de 2018. Como resultados, obteve-se uma evolução do estado inicial dos alunos para o estado após os alunos conhecerem o aplicativo, sendo que na primeira turma onde a pesquisa foi realizada, a média dos grupos que responderam às listas de exercícios passou de 7,33 para 9,56, já a segunda turma, a média de acertos passou de 5,56 para 7,11 e na terceira turma, a média de acertos passou de 5,25 para 8,75, mostrando que em todas as turmas houve uma melhoria no entendimento dos conceitos apresentados no produto educacional.
Um Estudo sobre a Equação da Onda Eletromagnética e a sua (não) Invariância sob Transformações de Galileu (Lorentz)
Authors: Felipe Jean , Veloso Vanessa
Published: June 2024

O presente trabalho tem como objetivo apresentar, de maneira didática e pedagógica, a demonstração de que a Equação da Onda Eletromangética é invariante sobre Transformaçãoes de Lorentz mas é não invariante quando submetida às Transformações de Galileu. Para um melhor entendimento, serão discutidos alguns conceitos oriundos da Teoria da Relatividade Restrita (TRR) e aplicações diretas desses conceitos (Transformações de Lorentz). Também será apresentado umabreve dicussão sobre as Transformações de Galileu bem como a dedução da Equação da Onda Eletromagnética, partindo da formulção diferencial das Equações de Maxwell.
Quiz com Aplicativo Socrative para o Desenvolvimento de Conceitos de Física Moderna
Authors: Rocha de Oliveira Érik , Da Costa Pinheiro Antônio Romero , Moreira Lima Carlos Henrique
Published: June 2024

A luz de novas tecnologias de informação na educação, que ganham cada vez mais espaço no ensino de física, propomos um quiz (teste rápido) no aplicativo Socrative, com a finalidade de relacionar o conhecimento do senso comum dos alunos do 3º ano do Ensino Médio à linguagem cientifica da física moderna. A pesquisa teve como metodologia qualitativa as seguintes etapas didáticas; primeiramente, aplicação de um questionário inicial, elaborado dentro do aplicativo, para avaliar o percentual de alunos que conseguiam correlacionar assuntos do cotidiano com a física, além da análise de uso da ferramenta; em seguida, o software foi utilizado dentro de uma sequência didática com fins metodológicos, concomitante ao plano pedagógico da escola e por fim, após a conclusão da sequência didática repetimos o questionário inicialmente aplicado, com o objetivo  de mapearmos a ocorrência de aprendizagem significativa do assunto proposto. Como resultado, inferimos que os alunos apresentaram uma retenção dos conceitos, a partir do uso do produto educacional proposto, baseada nos seus desempenhos no quis.
Sequência Didática Investigativa Baseada nos Três Momentos Pedagógicos de Delizoicov para a Determinação Experimental da Velocidade do Som no Ar.
Authors: De Oliveira Filho João Pessoa , Monteiro Júnior Francisco Nairon
Published: June 2024

A pesquisa em ensino de física tem apontado fortemente para a importância do uso do experimento numa perspectiva investigativa e problematizadora, como ferramenta na formação de cidadãos cientificamente alfabetizados. Tais atividades, dentre outras, podem assumir diferentes papéis em situações de ensino, possibilitando, além da aprendizagem significativa, o protagonismo do estudante, a tomada de decisão, a análise reflexiva e a construção de conclusões. Alinhados com esta perspectiva emancipatória, desenvolvemos um produto educacional composto de uma sequência didática, baseada no diálogo entre os três momentos pedagógicos, a aprendizagem significativa e o ensino sob medida, voltada para o ensino teórico e experimental referente à velocidade do som e sua medição. A aplicação deste produto educacional mostrou-se bastante satisfatória, onde pudemos perceber motivação, protagonismo, ficando evidente o desejo dos estudantes que o ensino da física pudesse ser desta forma, o que nos mostra que a experiência vivenciada construiu neles um novo olhar em relação à física. Além disso, os resultados experimentais e os mapas conceituais por eles produzidos dão mostra de que houve aprendizagem.
A FÍSICA EM UM DIA NA VIDA DE LÚCIA: DIVULGAÇÃO CIENTÍFICA PARA JOVENS E ADULTOS
Authors: Dos Santos Angela Maria , Simeão Carvalho Paulo , A. A. Gonçalves José
Published: June 2024

Esta é a história de Lúcia, uma jovem trabalhadora que, durante seu dia, gosta de aprender Física através das coisas que acontecem ao seu redor. Se você é curioso e quer compreender a Física de maneira simples, irá gostar de acompanhar a história de um dia na vida de Lúcia e divertir-se com ela. Este é um livro de divulgação científica.
FÍSICA FORENSE: O ESTADO DA ARTE NO ENSINO DE FÍSICA NO BRASIL
Authors: Angi Valin de Souza Wellinton , Besse Massini Gustavo , César Cardoso Fabiano
Published: June 2024

Física Forense é a área da Criminalística destinada a resolução de crimes que envolvam conceitos de Física, como em acidentes de trânsito e disparos de arma de fogo. Devido ao efeito didático que a Física Forense pode acarretar, objetiva-se neste artigo apresentar e analisar o cenário atual das pesquisas em Física Forense no ensino de Física no Brasil, por meio de artigos científicos, trabalhos de conclusão de curso e trabalhos publicados em eventos. Especificamente, busca-se conhecer o Estado da Arte dos trabalhos publicados na área e categorizá-los, analisando alguns aspectos, como: o nível escolar onde ocorrem as aplicações ou propostas, os Objetos de Conhecimento de Física e de Física Forense, como as propostas/aplicações estão organizadas e, se são da realidade do aluno ou fictícias. Alguns resultados apontam que as regiões sul e sudeste se destacam com mais trabalhos publicados, sendo a maioria deles voltados ao Ensino Médio; além disso, a maior parte utiliza atividades fictícias, e não da realidade dos estudantes. Finalmente, a Física Forense surge como um tema enriquecedor a ser utilizado em sala de aula, por facilitar o envolvimento e interação dos educandos, torná-los ativos e não passivos, e ser por essência um trabalho de investigação científica.
SIMULAÇÃO COMPUTACIONAL PARA O ENSINO DE ONDAS ESTACIONÁRIAS EM UMA CORDA
Authors: Dallagnol Alloy Marcelo , F. DallAgnol Fernando
Published: June 2024

O presente trabalho apresenta uma ferramenta didática que visa o ensino de ondas estacionárias em uma corda e foi desenvolvida com o propósito de minimizar os efeitos negativos no processo de ensino-aprendizagem diante da impossibilidade de acesso a um laboratório de Física. Ao menos três procedimentos experimentais podem ser aplicados com o objetivo de validar o comportamento das ondas estacionárias em uma corda.
Sequência didática para cinemática escalar, usando o software modellus: um estudo sobre o MRU, MRUV, queda livre e lançamento vertical para cima
Authors: Oliveira da Silva Valesca Taciele , Santos Antonio Marques dos , Da Camara Neto Calistrato Soares
Published: June 2024

Trazemos, neste artigo, o desenvolvimento e aplicação de um produto educacional direcionado para o ensino de cinemática escalar. O produto foi aplicado em uma turma da 1ª série do Ensino Médio, no Colégio Objetivo de João Câmara. Assim, considerando a demanda pela busca de alternativas metodológicas, compatíveis com as novas formas de ensinar e aprender, o presente trabalho tem como finalidade propor uma sequência didática, que foi desenvolvida sob a perspectiva da metodologia de sala de aula invertida e a aprendizagem significativa de David Ausubel, com objetivo de potencializar o processo de ensino e aprendizagem, de alguns conteúdos da cinemática escalar, sendo eles: Movimento Retilíneo Uniforme – MRU, Movimento Retilíneo Uniformemente Variável – MRUV, Queda Livre e Lançamento Vertical para Cima, utilizando o software Modellus. Foram desenvolvidos quatro simuladores, e em consonância a eles três questionários de diagnósticos iniciais, e três roteiros de aplicação, um para o simulador 1 – MRU, outro para o simulador 2 – MRUV e outro para os simuladores 3 e 4 – Queda Livre e Lançamento Vertical para Cima, além de um questionário de satisfação. Os questionários de diagnósticos iniciais, satisfação e roteiros de aplicação, foram ferramentas essenciais, na testagem da eficácia do produto educacional. Os resultados apontaram que a proposta gerou ganhos significativos, pois além de motivados através do uso das Tecnologias de Informação e Comunicação - TIC’s, a utilização da sala de aula invertida permitiu que os protagonistas em questão fossem os próprios estudantes, ou seja, os alunos tornaram- se sujeitos ativos ao longo de todo processo.
ANALISIS KUALITAS PENAWARAN (IPO) DAN DEBT TO EQUITY RATIO (DER) TERHADAP VOLUME PERDAGANGAN DI BURSA EFEK INDONESIA (BEI) SEBELUM COVID 19
Authors: Efi Friantin Siti Hayati , Putri Ika Swasti , Sagita Yanian Purwa
Published: June 2024

Pada penelitian ini menarik karena berfokus mempelajari pengaruh variabel independen Underpricing IPO dan Debt To Equity Ratio terhadap variabel dependen Volume Perdagangan di bursa efek indonesia dengan periode pengamatan 2016- 2019, periode sebelum covid -19. Periode ekonomi yang masih nomal.   Populasi yang digunakan adalah  perusahaan properti dan industri yang melakukan IPO tahun 2016-2019  di bursa efek Indonesia. Metode penelitian kuantitatif  menjadi pilihan  dengan teknik sampel yang digunakan adalah Purposive Sampling. Metode analisis yang digunakan pada pengujian variabel pada penelitian ini adalah statistik       deskriptif, uji asumsi klasik dan analisis regresi linier berganda.  Hasil pada penelitian ini adalah adanya pengaruh tidak signifikan antara variabel independen Underpricing IPO terhadap Volume Perdagangan dan adanya pengaruh signifikan antara variabel Debt To Equity Ratio terhadap Volume Perdagangan.

Kata kunci :

Underpricing IPO; Debt to  Equity  Ratio; Volume Perdagangan
PENGARUH KUALITAS PRODUK DAN PENETAPAN HARGA TERHADAP KEPUTUSAN PEMBELIAN (STUDI KASUS PADA TOKO DEVA ELEKTRONIK)
Authors: Eza Arfian Mahendra , Satya Irma , Suryawardana Edy
Published: June 2024

Penelitian ini bertujuan untuk mengetahui manfaat penerapan strategi kualitas produk dan penetapan harga pada Toko Deva Elektronik, dan mengetahui faktor pendukung dan penghambat dari strategi tersebut. Di dalam penelitian ini, mencari informasi mengenai manfaat penerapan strategi kualitas produk dan penetapan harga, faktor pendukung dan penghambat di dalam penerapan kualitas produk dan penetapan harga pada Toko Deva Elektronik. Metode penelitian yang digunakan adalah metode kualitatif deskriptif, dengan menggunakan triangulasi sumber, triangulasi metode, dan triangulasi waktu. Dengan partisipan yang berjumlah 5 orang, yang terdiri dari 1 pemilik Toko, 1 karyawan Toko, dan 3 pelanggan atau konsumen Toko. Hasil penelitian menunjukan bahwa penerapan strategi kualitas produk dan penetapan harga pada Toko Deva Elektronik memiliki manfaat sebagai berikut : 1. Peningkatan penjualan dan pendapatan, 2. Peningkatan jumlah konsumen, 3. Meluasnya lingkup jangkauan pasar. Faktor pendukung dan penghambat dalam penerapan strategi adalaah sebagai berikut : Faktor Pendukung antara lain : 1. Kualitas produk yang ditawarkan , 2. Harga yang bervariasi, 3. Kelengkapan Produk. Faktor Penghambat antara lain : 1.   Penjual harus komunikatif terhadap pembeli, 2. Banyaknya barang retur. Terdapat banyak manfaat dari penerapan strategi   kualitas produk dan penetapan harga pada Toko Deva Elektronik, jika dibandingkan dengan kedalanya, sehingga bisa dikatakan bahwa penerapan strategi ini bisa dikatakan sangat efektif   dalam meningkatkan penjualan, dan memperluas jangkauan pasar.

  

Kata kunci : Kualitas Produk; Penetapan Harga; Manfaat kualitas produk dan penetapan harga.
PENERAPAN DIGITAL MARKETING DALAM MENINGKATKAN PENJUALAN PRODUK AYANA STORE PATI
Authors: Larasati Tas'yana Ayu , Pradiptya Adhi , Mawardani Mita
Published: June 2024

Penelitian ini bertujuan untuk mengetahui mengenai penerapan strategi pemasaran yang digunakan oleh Ayana Store Pati serta mengetahui dampak dari penerapan strategi pemasaran yang dilakukan oleh Ayana Store Pati dalam meningkatkan penjualannya. Digital marketing adalah sesuatu yang tidak asing lagi saat ini. Banyak pelaku usaha yang memasarkan produknya melalui digital dengan alasan penerapan digital marketing dalam pemasaran dapat meningkatkan penjualan produk. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif dengan objek penelitian Ayana Store Pati. Sumber data akan diambil dari dokumen, hasil wawancara, dan hasil dari observasi. Dalam penelitian ini, wawancara dengan berbagai pertanyaan tentang topik penelitian dilakukan secara langsung. Hasil penelitian menunjukkan bahwa Ayana Store menggunakan digital marketing sebagai media pemasarannya dan promosi dengan memanfaatkan sosial media Instagram, Facebook, dan WhatsApp. Selain itu, Ayana Store Pati menggunakan media sosial untuk menginformasikan dan berkomunikasi dengan konsumen. Platform tersebut cukup efektif digunakan dalam menginformasikan produk Ayana Store Pati dan berinteraksi langsung dengan konsumen. Namun tetap muncul kendala yang dihadapi oleh Ayana Store Pati dalam menerapkan digital marketing adalah koneksi internet yang tidak stabil, keterlambatan dalam pengiriman, serta masalah internal karena kurangnya SDM akibat pesanan yang banyak karena promosi di media sosial. Akan tetapi dampak yang ditimbulkan dari penerapan digital marketing yang dilakukan Ayana Store Pati yaitu digital marketing dapat meningkatkan penjualan produk ayana Store Pati.

Kata Kunci :

Digital marketing; sosial media; strategi pemasaran; meningkatkan penjualan; promosi
Exploring the intersections of responsible AI for community wellbeing in local governance: A comprehensive review
Authors: Bala Dhandayuthapani V.
Published: June 2024

This article explores the relationship between artificial intelligence (AI) and community well-being for local governance. It investigates the potential use of AI to ease societal issues and improve community well-being. This article provides an overview of the impact of AI on community dynamics, smart urban planning, and integrating AI optimization with community well-being. The incorporation of smart applications into urban planning approaches is highlighted as a critical component, demonstrating AI's revolutionary potential for creating sustainable and inclusive landscapes. The main issue is the importance of combining AI optimization with community well-being, with a focus on responsible and ethical AI approaches that benefit the community. This review also goes over emotional AI and its ethical consequences, intellectual freedom in AI ethics, and AI's role in healthcare. This comprehensive analysis offers significant insights for researchers, policymakers, and practitioners looking to shape the ethical and equitable deployment of AI technology for societal benefit.
Learning more about the praxis of archaeology and advocacy in Southeast Asia
Authors:   Eberhard Karls Universität Tübingen, Kintanar Andrea Natasha
Published: June 2024

In Southeast Asia, Public Archaeology was generally practiced within the framework of cultural heritage management. Interest and efforts to rescue and protect cultural sites of cultural significance stemmed from the popularity of cultural heritage tourism. For America, the UK, and Europe, the practice of Public Archaeology started out with the intention to garner general public and government support for archaeological research. Throughout decades, theories and practices in the discipline evolved into something more extensive as it has become a subfield in archaeology and its own academic discourse. Public archaeology also gave way to a more mindful practice and has been effective in affecting behavioural change and given a voice to marginalised groups and communities. In recent years, archaeologists working in Southeast Asia have started to actively participate in uplifting the socioeconomic status and well-being of communities nearby archaeological sites. Public Archaeology practiced as advocacy is an emerging field in Southeast Asia and it is important to gather more work related to this.
Analysis of Pictographs at Phang-nga Bay, Western Coast of Peninsular Thailand | การวิเคราะห์ภาพเขียนสีที่อ่าวพังงา ชายฝั่งด้านตะวันตกของประเทศไทย
Authors:   Fine Arts Department, Thailand, Chanpaisalsilp Thawatchai
Published: June 2024

There were 10 pictographs sites discovered in the Phang-nga Bay. However, the scientific analysis of the rock paintings is not available. Therefore 214 pigment samples appeared on the rock walls at 10 sites were detected by pXRF and analyzed by the experts. These results suggest that rock paintings were probably created by several artists. It reflected more than one group occupied the area of the Phang-nga Bay. There is a need for further multidisciplinary studies on archaeology, ethnology, paleoecology, and geomorphology in order that the rock art identification will give information on interaction between human and nature. ปััจจุบัันมีีการค้้นพบัแหล่่งภาพเขีียนสีีหรือศิลิ่ ปัะถ้ำ􀄚ำาบัริเวณอ่าวพังงา จังหวัดพังงา จำานวน 10 แหล่่ง ซึ่่􀄙งยังไมี่มีีการ วิเค้ราะห์ทางวิทยาศิาสีตร์แต่อย่างใด นักวิจัยแล่ะผู้้เชีี่􀄙ยวชี่าญจ่งมีีการทดสีอบัแล่ะวิเค้ราะห์องค้์ปัระกอบัธาตุขีองสีีที􀄙ใชี่้ เขีียนภาพ จำานวน 214 ตัวอย่าง ด้วยเทค้นิค้รังสีีเอ็กซึ่์ (pXRF) ผู้ล่จากการวิเค้ราะห์พบัว่าภาพเขีียนสีีที􀄙อ่าวพังงา อาจมีี การเขีียนขี่􀄚นโดยกลุ่มีค้นหล่ากหล่ายกลุ่มีที􀄙อาศิัยอยใ่้ นพ􀄚ืนที􀄙อ่าวพังงา ซึ่􀄙่งในอนาค้ตมีีค้วามีจำาเปั็นต้องอาศิัยการศิ่กษา แบับัสีหวิทยาการ ได้แก่ โบัราณค้ดี ชี่าติพันธุ์วิทยา นิเวศิวิทยาโบัราณ แล่ะธรณีสีันฐาน เพื􀄙อให้ได้ขี้อมี้ล่ที􀄙ชีั่ดเจนถ้ำ่งค้วามี สีัมีพันธ์ระหว่างมีนุษย์แล่ะธรรมีชี่าติ
Determinants of Student Attrition in an Undergraduate Sport and Exercise Science Degree
Authors: Kee Lyn , Huynh Minh , Xanthos Paul , Davids Charlie , James Lachlan
Published: June 2024

The purpose of this study was to present a novel approach to identify factors that influence student attrition in an undergraduate Sport and Exercise Science (SpES) degree. A non-linear statistical technique was used to analyze demographic indicators of students enrolled in the first year of the SpES bachelor's degree at an Australian university (n = 312). Student dropout was successfully predicted using Chi-Squared Automatic Interaction Detection (CHAID). Using only four variables (i.e., Region, ATAR, Admission, & VCEBus), the model achieved an 87.50% classification accuracy. The article concludes with an endorsement of the proposed analysis to predict student dropout. Administrative and teaching-focused university staff may adopt the novel approach to identify the relevant demographic indicators for their respective institutions or programs of study in the management of student attrition. The limitations of this study are also discussed.
Biomechanical Analysis of Slingshot Grip dan Pull in Traditional Game
Authors: Rahesti Nonik , Irawan Fajar Awang , Long-Ren Chuang
Published: June 2024

Slingshot is a traditional game that has several basic techniques that must be mastered. Some of the basic techniques in the traditional slingshot game have not been fully understood by some players. This study aims to analyze the biomechanical grip and pull of slingshot in traditional games. This quantitative study used a sample consisting of 10 traditional slingshot game players in Semarang Regency. Kinematic data were obtained from the slingshot shooting video analysis using Kinovea software version 0.9.5. The kinematic data consisted of three phases: preparation, release, and followthrough. This study found that the ideal grip is a straight hand position that is parallel to the arm pull until an angle of 90o is formed. Effective and efficient pulling techniques are carried out by pulling and anchoring the rubber in the preparation phase right on the cheekbone as a support point. Hence, the rubber pull is consistent in the same position. Further study needs to be conducted to discuss the analysis of the length of the pulling and shooting accuracy.
Education Profiling for East Java Student-Athletes: Planning, Process, Assessment, and Expectations
Authors: Suroto Suroto , Kusnanik Nining Widyah , Pradana Febryansah Gilang Aris , Prakoso Bayu Budi , Bafirman Bafirman , Barlian Eri , Usman Arifuddin , Arimbi Arimbi , Sumaryanti Sumaryanti , Wijaya Made Agus
Published: June 2024

Dual-career student-athletes must be supported by rigorous training and academic processes that suit their needs. Unfortunately, student-athletes' academic performances are not as satisfactory as their sports achievements. Their sports training and the academic process are needed. This qualitative study aimed to analyze the academic services student-athletes receive from faculty and their expectations. A total of 30 studentathletes who had achieved sports achievements at regional, national, and international levels were interviewed about academic services ranging from planning, materials, learning processes, assessment, and expectations. The data were analyzed using the NVivo application. The findings of this study are that student academic services are stated to be the same between student-athletes and non-athletes. The faculty has provided special licensing services for student-athletes; there needs to be a better alignment of faculty and lecturer-level licensing. Student-athletes feel that the allocation of academic activities needs to be lowered, assignments are not by theconditions of student-athletes, and students need special athlete classes that are flexible to rigorous sports activities
Future Problem-Solving Skills and Its Relationship with Research Self-Efficacy in Post-Graduate students
Authors: Elballah Khaled Awad , Gaber Sherif Adel , Shahat Hussein Ahmed , Ibrahim Alia Hamed , Hasan Sumaia Attia Al
Published: June 2024

Research self-efficacy (RSE) and future problem-solving skills (FPSS) are considered essential elements that help post-graduate students. The current study examines the relationship between RSE and FPSS among college of education post-graduate students. The study sample comprised 98 post-graduate students, and the descriptive-correlational method was used. The researchers used the Future Problem Solving Scale (FPSSS), and research self-efficacy Scale (RSES). The results revealed that the research sample exhibited a high degree of FPSS and RSE, and a positive correlation between FPSS and RSE was observed. Regarding the gender variable, there was a difference in FPSS in favour of males and a difference in RSE in favour of females. With respect to disciplines, there was no difference between FPSS and RSE. Regarding the type of study, there were no differences among the research sample in FPSS; however, there were differences in RSE in favour of full-time students. The results also indicated that there were differences in FPSS and RSE, according to the state of study, in favour of those who completed their theses. It was also concluded that RSE can be predicted by FPSS. FPSS and RSE enhanced academic performance, critical thinking and creativity in the research sample. The research recommends the importance of developing FPSS in post-graduate programmes to enhance student performance in scientific research, promote critical thinking and encourage creativity in educational research.
Research Status of Medical English based on CNKI Bibliometric Analysis and its Development Trend in China: Professional Cultivation and Teacher Development
Authors: Kong Yuan , Ali Nor Liza
Published: June 2024

Medical English provides a good platform for China to learn advanced Western medical knowledge and align with the world's advanced medical level, especially after the COVID-19 pandemic. This article first uses the CNKI (China National Knowledge Infrastructure) bibliometric visualization analysis tool and adopts content analysis to search and statistically analyse 248 academic articles on medical English published in China from 2011 to 2023. From the aspects of publication volume, literature sources, author and institution distribution, research topics, research methods, progress analysis is conducted on these articles to review the status quo of medical English research in China. The findings showed that the number of medical English papers fluctuates. There are few hot topics in research that directly involve medical issues. There are also few research achievements on medical English high water content. Furthermore, the research methods of medical English are mainly quantitative and experiential while the majority of medical English researchers are English teachers from higher medical institutions. This has enlightening implications for the future development direction of medical English. The training of medical English professionals and the professional development of medical English teachers will become new directions for future medical English research and development. Subsequently, this study further explores new ideas for training medical English professionals in the post-pandemic era. Finally, this study proposes professional development strategies for one type of medical English teacher with an English educational background in the transitional period. This study aims to provide some implications for medical English teaching reform.