bluuebunny/crossref_metadata_2025 huggingface dataset:
Empiricism in non-communicable disease mortality measurement for the Asia-Pacific: lost in translation
Authors: Rao Chalapati , Kelly Matthew
Published: November 2020

Control of non-communicable diseases (NCDs) is a key target for the United Nations Sustainable Development Goals (SDGs) for 2030. Available information indicates that countries in the Asia-Pacific Region accounted for 63% of the global NCD mortality burden in 2016. The United Nations Economic and Social Commission for the Asia Pacific (UNESCAP) Regional SDG progress report for 2020 included estimates of trends in NCD mortality rates from 2000 to 2016, which showed considerable variation in national NCD mortality by sex and location.

However, while the UNESCAP report states that there was sufficient primary data to derive these NCD mortality estimates for all countries, the critical gaps in availability of national data on causes of death in the Asia-Pacific region are well known. A closer review identified that the UNESCAP obtained these estimates from the United Nations Statistics Division, which in turn obtained the same estimates from WHO. Further analysis revealed that these organisations used varying and often inconsistent terms to describe estimation methodology as well as primary data availability for different countries, with substantial potential for misinterpretation.

The analysis also found that for countries without primary data, WHO reported NCD mortality estimates were based on complex epidemiological models developed for the Global Burden of Disease (GBD) Study, and this contradicts the UNESCAP rating of primary data sufficiency. The GBD Study also derives modelled cause of death estimates for countries with national data, but these were different from WHO estimates for these countries. This article discusses prevailing international practices in using modelled estimates as a substitute for empirical data, and the implications of these practices for health policy. In conclusion, a strategic approach to strengthen national mortality statistics programmes in data deficient countries is presented, to improve NCD mortality measurement in the Asia-Pacific Region.
Massive open online course for type 2 diabetes self-management: adapting education in the COVID-19 era
Authors: Mackenzie Scott C , Cumming Kirsten M , Garrell David , Brodie Doogie , Wilson Lyn , Mehar Salma , Cunningham Scott G , Bickerton Alex , Wake Deborah J
Published: November 2020

Introduction

Type 2 diabetes self-management education is an essential component of type 2 diabetes care that is traditionally delivered in a face-to-face setting. In response to the recent COVID-19 pandemic, innovative solutions are urgently needed, allowing provision of self-management education that can be delivered in compliance with social distancing policies. Innovations that are self-service and can deliver education efficiently at low cost are particularly appealing to healthcare providers and commissioners.

Methods

We aimed to evaluate user uptake, dropout, acceptability, satisfaction, perceived short-term knowledge gain and health benefits/behaviour changes in relation to a free massive open online course (MOOC) in diabetes self-management education, created and delivered during the COVID-19 pandemic. This course, focusing on addressing knowledge and self-management needs for people with type 2 diabetes, made use of online interactive content including expert and patient videos, quizzes, moderated discussion boards and live social media that encouraged personal reflection and goal setting. User expectations and experiences were explored via survey-based methods. Here, we present our experience of developing the course and describe users’ experiences.

Results

1991 users registered interest in the course over a 2-week period, with 976 users starting the course and 640 (65.6%) users completing the course in full. Users engaged well, finding the course educational, user-friendly and motivating, demonstrating high completion rates and user satisfaction. A statistically significant (p<0.001) increase in self-reported self-management ability and health knowledge was observed among participants with type 2 diabetes.

Discussion

MOOCs in type 2 diabetes self-management education have great potential for delivering education efficiently at scale and low cost. Although engagement can be limited by digital literacy, benefits include flexible and remote access to up-to-date, evidence-based education delivered by a multidisciplinary team of healthcare professionals.
A study protocol for a phase II randomised, double-blind, placebo-controlled trial of sodium selenate as a disease-modifying treatment for behavioural variant frontotemporal dementia
Authors: Vivash Lucy , Malpas Charles B , Churilov Leonid , Walterfang Mark , Brodtmann Amy , Piguet Olivier , Ahmed Rebekah M , Bush Ashley I , Hovens Christopher M , Kalincik T , Darby David , Velakoulis Dennis , O'Brien Terence J
Published: November 2020

Introduction

Behavioural variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder often neuropathologically associated with the accumulation of abnormally hyperphosphorylated tau, for which there is currently no disease-modifying treatment. Previous work by our group has shown sodium selenate upregulates the activity of protein phosphatase 2 in the brain, increasing the rate of tau dephosphorylation. The objective of this study is to evaluate the efficacy and safety of sodium selenate as a disease-modifying treatment for bvFTD.

Methods and analysis

This will be a multisite, phase IIb, double-blind placebo-controlled trial of sodium selenate. One hundred and twenty participants will be enrolled across 4 Australian academic hospitals. Following screening eligible participants will be randomised (1:1) to sodium selenate (15 mg three times a day) or placebo for 52 weeks. Participants will have regular safety and efficacy visits throughout the study period. The primary study outcome will be percentage brain volume change (PBVC) as measured on MRI over 52 weeks of treatment. This will be analysed with a general linear model (analysis of covariance (ANCOVA)) with the PBVC as an output, the treatment as an input and the baseline brain volume as covariate for adjustment purposes. Secondary outcomes include safety and tolerability measures, and efficacy measures; change in cerebrospinal fluid total-tau, Addenbrooke’s Cognitive Examination-III and Cambridge Behavioural Inventory-Revised scores over the 52 weeks of treatment. These will also be analysed with ANCOVA where the corresponding baseline measure will be incorporated in the model. Additional exploratory outcomes will include other imaging, cognitive and biospecimen analyses.

Ethics and dissemination

The study was approved by the Human Research and Ethics Committee of the lead site as part of the Australian Multisite Ethics approval system. The results of the study will be presented at national and international conferences and published in peer-reviewed journals.

Trial registration number

ACTRN12620000236998 .
A novel ACT-based video game to support mental health through embedded learning: a mixed-methods feasibility study protocol
Authors: Edwards Darren J , Kemp Andrew H
Published: November 2020

Introduction

In recent years, serious video games have been used to promote emotional regulation in individuals with mental health issues. Although these therapeutic strategies are innovative, they are limited with respect to scope of treatment, often focusing on specific cognitive skills, to help remediate a specific mental health disorder.

Objective

Here, we propose a protocol for assessing the feasibility of a novel acceptance and commitment therapy (ACT)-based video game for young adults.

Methods and analysis

The Medical Research Council (MRC) framework will be used for developing a complex intervention to design and test the feasibility of an ACT-based video game intervention using a mixed-methods approach involving qualitative and quantitative data. The primary outcomes will include feasibility testing of recruitment processes and the acceptability of the intervention through qualitative interviews, attendance and rates of attrition. Secondary outcomes will involve a series of quantitative questionnaires to obtain effect sizes for power analysis, allowing for the ideal sample size for an appropriately powered, randomised controlled trial to be determined.

Ethics and dissemination

This study has been approved by the Psychology Department Research Ethics Committee (2020-4929-3923) at Swansea University in the UK. Dissemination activities will involve publications in peer-reviewed journals, presentations at local and national conferences and promotion through social media.

Trial registration number

NCT04566042.
Improving management of hospitalised patients with COVID-19: algorithms and tools for implementation and measurement
Authors: Salem Ahmed , Elamir Hossam , Alfoudri Huda , Shamsah Mohammed , Abdelraheem Shams , Abdo Ibtissam , Galal Mohammad , Ali Lamiaa
Published: November 2020

Background

The COVID-19 pandemic represents an unprecedented challenge to healthcare systems and nations across the world. Particularly challenging are the lack of agreed-upon management guidelines and variations in practice. Our hospital is a large, secondary-care government hospital in Kuwait, which has increased its capacity by approximately 28% to manage the care of patients with COVID-19. The surge in capacity has necessitated the redeployment of staff who are not well-trained to manage such conditions. There was a great need to develop a tool to help redeployed staff in decision-making for patients with COVID-19, a tool which could also be used for training.

Methods

Based on the best available clinical knowledge and best practices, an eight member multidisciplinary group of clinical and quality experts undertook the development of a clinical algorithm-based toolkit to guide training and practice for the management of patients with COVID-19. The team followed Horabin and Lewis’ seven-step approach in developing the algorithms and a five-step method in writing them. Moreover, we applied Rosenfeldet al’s five points to each algorithm.

Results

A set of seven clinical algorithms and one illustrative layout diagram were developed. The algorithms were augmented with documentation forms, data-collection online forms and spreadsheets and an indicators’ reference sheet to guide implementation and performance measurement. The final version underwent several revisions and amendments prior to approval.

Conclusions

A large volume of published literature on the topic of COVID-19 pandemic was translated into a user-friendly, algorithm-based toolkit for the management of patients with COVID-19. This toolkit can be used for training and decision-making to improve the quality of care provided to patients with COVID-19.
Effect of blood pressure lowering drugs and antibiotics on abdominal aortic aneurysm growth: a systematic review and meta-analysis
Authors: Golledge Jonathan , Singh Tejas P
Published: November 2020

Objective

There is currently no medical treatment proven to limit abdominal aortic aneurysm (AAA) progression. The aim of this systematic review and meta-analysis was to pool data from previous randomised controlled trials assessing the efficacy of blood pressure-lowering and antibiotic medications in limiting AAA growth and AAA-related events, that is, rupture or repair.

Methods

A systematic literature search was performed to identify randomised controlled trials that examined the efficacy of blood pressure-lowering medications or antibiotics in reducing AAA growth and AAA-related events. AAA growth (mm/year) was measured by ultrasound or computed tomography imaging. Meta-analyses were performed using random effects models. A subanalysis was conducted including trials that investigated tetracycline or macrolide antibiotics.

Results

Ten randomised controlled trials including 2045 participants with an asymptomatic AAA were included. Follow-up was between 18 and 63 months. Neither blood pressure-lowering medications (mean growth±SD 2.0±2.4 vs 2.3±2.7 mm/year; standardised mean difference (SMD) −0.07, 95% CI −0.19 to 0.06; p=0.288) or antibiotics (mean growth±SD 2.6±2.1 vs 2.6±2.5 mm/year; SMD −0.11, 95% CI −0.38 to 0.16; p=0.418) reduced AAA growth or AAA-related events (blood pressure-lowering medications: 92 vs 95 events; risk ratio (RR) 0.86, 95% CI 0.66 to 1.11; p=0.244; and antibiotics: 69 vs 73 events; RR 0.93, 95% CI 0.69 to 1.25; p=0.614). The subanalysis of antibiotics showed similar results.

Conclusions

This meta-analysis suggests that neither blood pressure-lowering medications or antibiotics limit growth or clinically relevant events in people with AAAs.
Exploring CP-violation, via heavy neutrino oscillations, in rare B meson decays at Belle II
Authors: Cvetič Gorazd , Kim C. S. , Mendizabal Sebastian , Zamora-Saá Jilberto
Published: November 2020

In this article we study the rare B-meson decay via two on-shell almost-degenerate Majorana Heavy Neutrinos, into two charged leptons and two pseudoscalar mesons ($$B^{\pm } \rightarrow D^0 \ell ^{\pm }_1 \ell ^{\pm }_2 \pi ^{\mp }$$

B
±

→

D
0

ℓ
1
±

ℓ
2
±

π
∓

). We consider the scenario where the heavy neutrino masses are $$\sim 2$$

∼
2

GeV and the heavy-light mixing coefficients are $$|B_{\ell N}|^2 \sim 10^{-5}$$

|

B

ℓ
N

|

2

∼

10

-
5

, and evaluate the possibility to measure the CP-asymmetry at Belle II. We present some realistic conditions under which the asymmetry could be detected.
Chapter 1 Introduction to the Jurassic Arabian Intrashelf Basin
Authors: Wilson A. O.
Published: November 2020

The Jurassic Arabian Intrashelf Basin provides the setting for the world's greatest conventional oil reserves, including the world's largest oilfield, the supergiant Ghawar field. The stratigraphic interval corresponding to the development and infill of the Arabian Intrashelf Basin is from the uppermost Dhruma Formation to the top of the Hith Anhydrite Formation, spanning the late Bathonian–early Callovian to Tithonian. Many areas of the intrashelf basin have been well described in recent years and the stratigraphic succession has been defined in sequence concepts, but the regional development of the intrashelf basin has not been well synthesized. This Memoir builds on published data to give a regional interpretation of the geological evolution of the Arabian Intrashelf Basin. This introductory chapter reviews some of the earlier work, summarizes the key events and elements in the geological history of the Arabian Intrashelf Basin and gives a brief review of the history of petroleum exploration in this region. It is intended to serve as an extended abstract to introduce the general setting and summarize the contents of this Memoir, including some of the proposed revisions of depositional models, correlations and the sequence nomenclature, providing a context for considering and evaluating each subsequent chapter. The themes summarized in this chapter are documented and discussed in much greater detail in the subsequent chapters of this Memoir.
Chapter 3 Lithostratigraphy and depositional characteristics, age dating and sequence stratigraphy
Authors: Wilson A. O.
Published: November 2020

This chapter reviews the lithostratigraphy, biostratigraphy, age dating and sequence stratigraphy of the Arabian Intrashelf Basin to document the basic data used in the interpretations in this Memoir. The factors important to understanding these topics are discussed, including the typical facies, general depositional models, the effects of dolomitization, well log characteristics and the problems with obtaining precise age dates. Comments are included to show the interpretations preferred in this Memoir.
On Progressive Type-II Censored Samples from Alpha Power Exponential Distribution
Authors: Salah Mukhtar M.
Published: November 2020

In this paper the two-parameter

α

-power exponential distribution is studied. We study the two-parameter

α

-power exponential

μ
,
λ

distribution with the location parameter

μ
>
0

and scale parameter

λ
>
0

under progressive Type-II censored data with fixed shape parameter

α

. We estimate the maximum likelihood estimators of these unknown parameters numerically since it cannot be solved analytically. We use the approximate best linear unbiased estimators

μ

∗

and

λ

∗

, as an initial guesses to obtain the MLEs

μ
^

and

λ
^

. We estimate the interval estimation of these unknowns’ parameters. Monte Carlo simulations are performed and data examples have been provided for illustration and comparison.
Study of Dust-Acoustic Multisoliton Interactions in Strongly Coupled Dusty Plasmas
Authors: Kabalan Najah , Ahmad Mahmoud , Asad Ali
Published: November 2020

The effect of the structure parameter on the compressibility of dust grains and soliton behavior in a dusty plasma system consisting of Maxwellian electrons, ions, and dust grains charged with a negative charge has been studied. In the theoretical study, a reductive perturbation technique was used to derive the Korteweg-de Vries (KdV) equation and employ the Hirota bilinear method to obtain multisoliton solution. It is found that coupling and structure parameters have a clear effect on the compressibility. These changes in the compressibility affected the amplitude and width of interactive solitons, in addition to the phase shifts resulting from the interaction. These results can be used to understand the behavior of solitary waves that occur in various natural and laboratory plasma environments with dust impurity situations.
Two-Stage Robust Optimization for the Orienteering Problem with Stochastic Weights
Authors: Shang Ke , Chan Felix T. S. , Karungaru Stephen , Terada Kenji , Feng Zuren , Ke Liangjun
Published: November 2020

In this paper, the two-stage orienteering problem with stochastic weights is studied, where the first-stage problem is to plan a path under the uncertain environment and the second-stage problem is a recourse action to make sure that the length constraint is satisfied after the uncertainty is realized. First, we explain the recourse model proposed by Evers et al. (2014) and point out that this model is very complex. Then, we introduce a new recourse model which is much simpler with less variables and less constraints. Based on these two recourse models, we introduce two different two-stage robust models for the orienteering problem with stochastic weights. We theoretically prove that the two-stage robust models are equivalent to their corresponding static robust models under the box uncertainty set, which indicates that the two-stage robust models can be solved by using common mathematical programming solvers (e.g., IBM CPLEX optimizer). Furthermore, we prove that the two two-stage robust models are equivalent to each other even though they are based on different recourse models, which indicates that we can use a much simpler model instead of a complex model for practical use. A case study is presented by comparing the two-stage robust models with a one-stage robust model for the orienteering problem with stochastic weights. The numerical results of the comparative studies show the effectiveness and superiority of the proposed two-stage robust models for dealing with the two-stage orienteering problem with stochastic weights.
Evaluation of the Existing Solar Energy and Rainwater Potential in the Total Roof Area of Buildings: Izmit District Example
Authors: Kaya Mehmet
Published: November 2020

In this research, an exemplary study has been conducted in order to draw attention to the importance of evaluating the existing potential on the roofs of buildings. This research offers an evaluation of the existing solar energy and rainwater potential on the total roof area of the buildings in the Izmit district, which is a central district of Kocaeli province, one of the busiest centers of industry in Turkey. The calculations in this study were carried out by using the data obtained from various institutions. As a result of these calculations, the ratio of electrical energy that can be provided with photovoltaic systems on roofs to meet the annual electricity consumption of the district was found to be 203.581%, and the annual solar energy utilization rate for a family of 4 to bring 240 liters of daily use water temperature to 60°C with an 8 m2 collector area was calculated as 66%. In addition, the ratio of rainwater that can be collected from the total roof area of the existing buildings in the district to meet the domestic water consumed by the district was found to be 33.27%.
Brief Mindfulness Meditation Induces Gray Matter Changes in a Brain Hub
Authors: Tang Rongxiang , Friston Karl J. , Tang Yi-Yuan
Published: November 2020

Previous studies suggest that the practice of long-term (months to years) mindfulness meditation induces structural plasticity in gray matter. However, it remains unknown whether short-term (<30 days) mindfulness meditation in novices could induce similar structural changes. Our previous randomized controlled trials (RCTs) identified white matter changes surrounding the anterior cingulate cortex (ACC) and the posterior cingulate cortex (PCC) within 2 to 4 weeks, following 5-10 h of mindfulness training. Furthermore, these changes were correlated with emotional states in healthy adults. The PCC is a key hub in the functional anatomy implicated in meditation and other perspectival processes. In this longitudinal study using a randomized design, we therefore examined the effect of a 10 h of mindfulness training, the Integrative Body-Mind Training (IBMT) on gray matter volume of the PCC compared to an active control—relaxation training (RT). We found that brief IBMT increased ventral PCC volume and that baseline temperamental trait—an index of individual differences was associated with a reduction in training-induced gray matter increases. Our findings indicate that brief mindfulness meditation induces gray matter plasticity, suggesting that structural changes in ventral PCC—a key hub associated with self-awareness, emotion, cognition, and aging—may have important implications for protecting against mood-related disorders and aging-related cognitive declines.
Speed Grade Evaluation of Public-Transportation Lines Based on an Improved T-S Fuzzy Neural Network
Authors: Zhang Shunfeng , Li Peiqing , Zhong Biqiang , Wu Jin
Published: November 2020

This paper proposes an evaluation method based on a T-S fuzzy neural network for evaluating the speed grade of public-transport lines in the context of large-scale rail-transit planning and construction in Hangzhou. The six-dimensional data of morning peak/evening peak average speed, average speed at peak, average station distance, proportion of dedicated lanes, and nonlinear coefficients were selected as input data for the neural network to output the operating speed grade of bus lines. Improving and optimizing the membership function of the Takagi–Sugeno (T-S) model improves its predicted result accuracy compared to a traditional T-S model. The line data of 28 typical trunk lines or expressways in Hangzhou were used as an example; the results demonstrate that the speed grade evaluation method based on an improved T-S fuzzy neural network can effectively and quickly evaluate the speed grade of Hangzhou public-transportation lines. This paper presents a novel analysis and method for large-scale rail-transit planning and evaluation of urban public-transport lines. The aim is to provide practical instruction for the subsequent optimization of public-transportation lines in Hangzhou.
Security Analysis on “Anonymous Authentication Scheme for Smart Home Environment with Provable Security”
Authors: Xu Meijia , Dong Qiying , Zhou Mai , Wang Chenyu , Liu Yangyang
Published: November 2020

As an important application of the Internet of Things, smart home has greatly facilitated our life. Since the communication channels of smart home are insecure and the transmitted data are usually sensitive, a secure and anonymous user authentication scheme is required. Numerous attempts have been taken to design such authentication schemes. Recently, Shuai et al. (Computer & Security 86(2019):132146) designed an anonymous authentication scheme for smart home using elliptic curve cryptography. They claimed that the proposed scheme is secure against various attacks and provides ideal attributes. However, we show that their scheme cannot resist inside attack and offline dictionary attack and also fails to achieve forward secrecy. Furthermore, we give some suggestions to enhance the security of the scheme. These suggestions also apply to other user authentication schemes with similar flaws.
Trust-Based Missing Link Prediction in Signed Social Networks with Privacy Preservation
Authors: Kou Huaizhen , Wang Fan , Lv Chao , Dong Zhaoan , Huang Wanli , Wang Hao , Liu Yuwen
Published: November 2020

With the development of mobile Internet, more and more individuals and institutions tend to express their views on certain things (such as software and music) on social platforms. In some online social network services, users are allowed to label users with similar interests as “trust” to get the information they want and use “distrust” to label users with opposite interests to avoid browsing content they do not want to see. The networks containing such trust relationships and distrust relationships are named signed social networks (SSNs), and some real-world complex systems can be also modeled with signed networks. However, the sparse social relationships seriously hinder the expansion of users’ social circle in social networks. In order to solve this problem, researchers have done a lot of research on link prediction. Although these studies have been proved to be effective in the unsigned social network, the prediction of trust and distrust in SSN has not achieved good results. In addition, the existing link prediction research does not consider the needs of user privacy protection, so most of them do not add privacy protection measures. To solve these problems, we propose a trust-based missing link prediction method (TMLP). First, we use the simhash method to create a hash index for each user. Then, we calculate the Hamming distance between the two users to determine whether they can establish a new social relationship. Finally, we use the fuzzy computing model to determine the type of their new social relationship (e.g., trust or distrust). In the paper, we gradually explain our method through a case study and prove our method’s feasibility.
Outer Plexiform Layer Angle: A Prognostic Factor for Idiopathic Macular Pucker Surgery
Authors: Liao Ding-Ying , Liu Jorn-Hon , Zheng Yu-Ping , Wang Jian-Ming , Chao Hsiao-Ming
Published: November 2020

Purpose. To investigate the efficacy of idiopathic macular pucker (epimacular membrane) surgery and to identify the possible prognostic factor. Methods. This was a retrospective study which enrolled 38 patients with idiopathic macular pucker who underwent 23-gauge pars plana vitrectomy (PPV) with indocyanine green-assisted peeling of epiretinal membrane (ERM) and internal limiting membrane (ILM). Visual outcomes were assessed at the baseline and during the follow-up including best-corrected visual acuity (BCVA) and metamorphopsia score, as well as outer plexiform layer (OPL) angle and central retinal thickness (CRT) using spectral-domain optical coherence tomography (SD-OCT). A comparison was made between patients with the prepeeling CRTs ≥500 μm and those <500 μm. A comparison was also made between patients with the prepeeling OPL angles ≥130° and those <130°. Based on the prepeeling parameters, the correlations between various prepeeling and postpeeling visual functions were analyzed. Results. Mean follow-up was 36.07 ± 4.62 months (range 1.30–96.70 months). BCVA was significantly improved from 0.26 ± 0.03 to 0.67 ± 0.04

p
<
0.001

; metamorphopsia score was significantly reduced from 1.42 ± 0.16 to 0.61 ± 0.08

p
<
0.001

; CRT was significantly decreased from 519.62 ± 13.41 μm to 385.37 ± 8.97 μm

p
<
0.001

. Greater prepeeling OPL angle (≥130°) was associated with significantly greater BCVA improvement (Snellen E/LogMAR:

p
=
0.01
/
0.03

) and greater metamorphopsia reduction

p
=
0.03

, as compared to smaller OPL angle (<130°) with less BCVA improvement and less metamorphopsia reduction. However, the final BCVA improvement and metamorphopsia reduction relevant to the prepeeling smaller CRT (<500 μm) did not significantly differ from that relevant to the prepeeling greater CRT (≥500 μm;

p
>
0.05

). Endophthalmitis, retinal tear, or retinal detachment was not observed after peeling. Conclusion. Indocyanine green-assisted ERM/ILM peeling combined with small gauge vitrectomy is associated with significant visual acuity improvement and metamorphopsia reduction in patients with idiopathic macular pucker. Greater prepeeling OPL angle rather than CRT might act as a useful prognostic factor in predicting better final visual functional outcomes.
Calculation Method for Inflow Performance Relationship in Sucker Rod Pump Wells Based on Real-Time Monitoring Dynamometer Card
Authors: Zhang Ruichao , Yin Yuqiong , Xiao Liangfei , Chen Dechun
Published: November 2020

Based on the informatization and intelligent construction of an oilfield, this paper proposes a new method for calculating inflow performance relationship in sucker rod pump wells, which solves the limitations of current IPR curve calculation method in practical application. By analyzing the forming principle of the dynamometer card, the plate of abnormal dynamometer card is created innovatively, and the recognition model of abnormal dynamometer card based on “feature recognition” is established to ensure the accuracy of the dynamometer card. By analyzing the curvature of each point on the curve of downhole pump dynamometer card, the opening and closing points of standing valve and traveling valve are determined, and the models for calculating fluid production and bottom hole flowing pressure are established to obtain the data of fluid production and bottom hole flowing pressure of sucker rod pump wells. Finally, a calculation model of inflow performance relationship fitted with the calculated fluid production and bottom hole flowing pressure data based on genetic algorithm is established to realize calculation of oil well inflow performance relationship curve. The field application and analysis results show that the inflow performance relationship curve calculated by the model in this paper fits well with the measured data points, indicating that the calculation model has high accuracy and can provide theoretical and technical support for the field. Moreover, the real-time acquisition of dynamometer cards can provide real-time data source for this method, improve the timeliness of oil well production analysis, and help to reduce the production management costs and improve the production efficiency and benefit.
A Graphical Programming Language and Its Supporting Tool for Insect Intelligent Building
Authors: Chen Wenjie , Yang Qiliang , Zhao Shuo , Xing Jianchun , Zhou Qizhen
Published: November 2020

The emerging Insect Intelligent Building (I2B) platform is pioneering a new realm in intelligent buildings. I2B has a distributed and decentralized network structure with intelligent nodes, and the key enabler is an application (APP) that functions to process information from intelligent nodes and accomplish complex control tasks in a decentralized network. To develop APPs for I2B, a proper programming language is the foremost goal; however, existing programming languages cannot be applied directly due to I2B's unique structure and distinction of application domains. This paper aims to provide language support for a direct and friendly development of I2B APPs. We propose a graphical programming language that adapts to the operating characteristics of I2B and users' habits of buildings. Specifically, we first analyze the domain characteristics of the proposed language and present a general programming language model illustrated with a motivating example. Then, we investigate the detailed design, definition, and usage of graphic elements. Additionally, we implement a prototype support tool for the graphical programming language to develop I2B APPs. Moreover, we use the application example of a building's constant pressure control for evaluating the effectiveness of our work.
Gastrointestinal Cancer Survival and Radiation Exposure among Atomic Bomb Survivors: The Life Span Study
Authors: Bockwoldt Brandie , Sugiyama Hiromi , Tsai Kevin , Bhatti Parveen , Brenner Alina V. , Hu Audrey , Kerr Kathleen F. , Morenz Eric , French Benjamin , Phipps Amanda I.
Published: November 2020

Background:

Radiation exposure is an established risk factor for the development of several forms of cancer, including gastrointestinal cancers. However, few studies have investigated the relationship between prediagnostic radiation exposure and survival after cancer diagnosis.

Methods:

Participants in the Life Span Study (LSS) of atomic bomb survivors who were diagnosed with a first primary invasive stomach, colon, or rectal cancer between 1958 and 2009 were followed for mortality during 1958–2014. Cox regression models were used to calculate HRs and 95% confidence intervals (CI) for associations of radiation dose from atomic bomb exposure with survival (cancer-specific and overall) after cancer diagnosis. Analyses were adjusted for city of primary exposure, sex, age at diagnosis, and year of diagnosis.

Results:

We identified 7,728 eligible patients with cancer for analysis. We observed no statistically significant associations between radiation dose and cancer-specific survival among LSS participants with a gastrointestinal cancer. Higher radiation doses (≥1 Gy) were suggestively, but not significantly, associated with modestly poorer cancer-specific survival for colon cancer only (HR, 1.38; 95% CI, 0.90–2.12), and were associated with poorer overall survival regardless of cancer site.

Conclusions:

Although radiation exposure is associated with increased risk of gastrointestinal cancer incidence and mortality, study results are inconclusive about an association between prediagnostic radiation exposure and survival after gastrointestinal cancer diagnosis.

Impact:

Radiation exposure from the atomic bomb before gastrointestinal cancer diagnosis was not associated with cancer survival, but should be evaluated in relation to survival for other cancer types.
Eccentric Cycling Training Improves Health-Related Quality of Life in Adolescents with Obesity
Authors: Julian Valérie , Thivel David , Miguet Maud , Pereira Bruno , Lambert Céline , Costes Frédéric , Richard Ruddy , Duclos Martine
Published: November 2020

Introduction: While eccentric (ECC) training appears to be more efficient than concentric (CON) training at improving body composition in adolescent with obesity, its impact on health-related quality of life (HRQOL) has never been studied. Objective: The aim of this study is to compare the effects of 2 cycling training modalities, i.e., ECC vs. CON, in adolescents with obesity on HRQOL and health perception (HP). Methods: A total of 24 adolescents with obesity, aged 12–16 years, were randomized to either a 12-week ECC or a CON cycling training program performed at the same oxygen consumption (VO2). Anthropometric measurements, body composition, maximal incremental tests, HRQOL (Vécu et Santé Percue de l’Adolescent [VSP-A], Medical Outcome Study Short Form [SF-36]), and HP were assessed at before and after training. Results and Conclusion: Both CON and ECC cycling trainings promoted significant improvements in BMI, VO2peak, total fat mass, and fat-free mass, with better improvements in body composition parameters in the ECC group (p < 0.05). The VSP-A total score increased after CON (p < 0.01) and ECC (p < 0.001) training, with better enhancement for the ECC group (p < 0.05). The SF-36 physical score increased after both CON (p < 0.01) and ECC (p < 0.001) trainings. The global HP score increased only after ECC training (p < 0.001). Except for the energy-vitality item, no significant correlation was found between changes in HRQOL and its subdomains and anthropometric, body composition, and functional parameters. Both ECC and CON cycling trainings are associated with positive changes in HRQOL and HP. However, ECC seems to induce greater improvements in HRQL and HP than CON cycling training, which is probably not due to the anthropometric, body composition, and functional changes.
Clinical Predictors of Transient versus Persistent Neonatal Hyperinsulinism
Authors: Falzone Nicole , Harrington Jennifer
Published: November 2020

Introduction: Hyperinsulinism (HI), the most common neonatal cause of persistent hypoglycemia, can be associated with prolonged hospitalizations and risk for long-term neurological sequelae. Rapid identification of transient versus persistent forms of HI is crucial to optimize management. Objectives: The aims of the study were to assess the ability of clinical and biochemical features at presentation to predict transient versus persistent HI, and to evaluate differences in hospital outcomes. Methods: This study is a retrospective review of 79 infants with HI admitted to the Hospital for Sick Children, Toronto, from 2012 to 2017. Patients were classified into 3 groups: transient and the 2 persistent forms, diazoxide responsive and diazoxide unresponsive (DU). Results: Infants with birth weight >90th percentile had an 8-fold increased risk of having a persistent form of HI (OR 8.8, 95% CI 2.5–30) and a 21-fold increased risk of having a DU form of HI (OR 21.1, 95% CI 4.9–91.8). The majority of children with transient HI and a birth weight >90th percentile were born to mothers with gestational diabetes. There were no other useful clinical or biochemical presenting features that differentiated the groups. There were significant differences in outcome measures, with the DU children more likely to require gastrostomy tube insertion and have an extended length of hospital admission. Conclusion: A higher birth weight in the absence of maternal gestational diabetes is highly associated with a persistent form of HI. Given the marked difference in clinical outcomes between groups, expedited genetic testing should be considered in infants with this presentation to inform clinical management.
Age Conditional Probability of Ocular and Ocular Adnexal Malignancies
Authors: Nittmann Mathias , Margo Curtis E.
Published: November 2020

Aim: The aim of this study was to discuss and illustrate the role age-conditional probability has in communicating risk of developing ocular and ocular adnexal malignancies. Methods: Cross-sectional incidence for retinoblastoma, uveal melanoma, conjunctival melanoma, and lacrimal gland carcinomas from 2000 to 2017 were obtained from the Surveillance, Epidemiology and End Results (SEER) database. Incidence rates were age-adjusted to the 2000 United States population. Age-adjusted incidence was converted to age-interval and cumulative risks. Outcomes were examined in 20-year intervals and cumulatively for adult cancers and yearly for retinoblastoma. Results: The risk of each malignancy displayed age-dependent variation. For adult malignancies, men were at higher risk at most age intervals. Uveal melanoma had the greatest cumulative lifetime risk. The probability of developing retinoblastoma declines precipitously after age 3 years. Conclusions: Age-conditional probability of developing cancer is a conceptually friendly means of understanding and communicating risk. It is particularly useful in comparing the risks of uncommon or rare cancers, such as those found in and around the eye. The assessment of risk in terms of age-conditional probability is a versatile and an underutilized pedagogical tool.
PREvention of VENous Thromboembolism in Hemorrhagic Stroke Patients – PREVENTIHS Study: A Randomized Controlled Trial and a Systematic Review and Meta-Analysis
Authors: Paciaroni Maurizio , Agnelli Giancarlo , Alberti Andrea , Becattini Cecilia , Guercini Francesco , Martini Giuseppe , Tassi Rossana , Marotta Giovanna , Venti Michele , Acciarresi Monica , Mosconi Maria Giulia , Marcheselli Simona , Fratticci Lara , D’Amore Cataldo , Ageno Walter , Versino Maurizio , De Lodovici Maria Luisa , Carimati Federico , Pezzini Alessandro , Padovani Alessandro , Corea Francesco , Scoditti Umberto , Denti Licia , Tassinari Tiziana , Silvestrelli Giorgio , Ciccone Alfonso , Caso Valeria
Published: November 2020

Background: In this randomized trial, currently utilized standard treatments were compared with enoxaparin for the prevention of venous thromboembolism (VTE) in patients with intracerebral hemorrhage (ICH). Methods: Enoxaparin (0.4 mg daily for 10 days) was started after 72 h from the onset of ICH. The primary outcome was symptomatic or asymptomatic deep venous thrombosis as assessed by ultrasound at the end of study treatment. The safety of enoxaparin was also assessed. We included the results of this study in a meta-analysis of all relevant studies comparing anticoagulants with standard treatments or placebo. Results: PREVENTIHS was prematurely stopped after the randomization of 73 patients, due to the low recruitment rate. The prevalence of any VTE at 10 days was 15.8% in the enoxaparin group and 20.0% in the control group (RR 0.79 [95% CI 0.29–2.12]); 2.6% of enoxaparin and 8.6% of standard therapy patients had severe bleedings (RR 0.31 [95% CI 0.03–2.82]). When these results were meta-analyzed with the results of the selected studies (4,609 patients; 194 from randomized trials), anticoagulants were associated with a nonsignificant reduction in any VTE (OR 0.81; 95% CI 0.43–1.51), in pulmonary embolism (OR 0.53; 95% CI, 0.17–1.60), and in mortality (OR 0.85; 95% CI 0.64–1.12) without increase in hematoma enlargement (OR 0.97; 95% CI, 0.31–3.04). Conclusions: In patients with acute ICH, the use of anticoagulants to prevent VTE was safe but the overall level of evidence was low due to the low number of patients included in randomized clinical trials.
The Immune-Modulatory Properties of iPSC-Derived Antigen-Presenting Cells
Authors: Ackermann Mania , Dragon Anna Christina , Lachmann Nico
Published: November 2020

Antigen-presenting cells (APCs), such as dendritic cells (DCs) and macrophages, are important regulators of the immune system, as they connect the innate and adaptive immunity by critically regulating T-cell responses. Thus, APCs are involved in both tissue homeostasis and tolerance, but also coordinate immune responses in case of infection and inflammation. Primary APCs are commonly generated from peripheral blood-derived monocytes and have been used as cell therapeutics in several (pre-)clinical settings, e.g., immune oncology, however, with varying efficiency. One promising alternative to study antigen presentation in vitro and to develop novel cell-based therapies are induced pluripotent stem cells (iPSCs). IPSCs can nowadays be generated from a variety of different cell types using several refined reprogramming techniques. Given their unlimited proliferation and differentiation potential, they hold great promise for regenerative medicine, and recently, first iPSC derivatives have found their way into first clinical studies for cell-based therapies. In this review article, we will give a brief overview of current methods for the generation and applications of primary APCs, but also specifically focus on different strategies for the generation of defined subsets of DCs and macrophages from human PSCs. Moreover, we will highlight the potential but also hurdles for the clinical translation of iPSC-derived APCs.
Benefit–Risk Tradeoffs in Assessment of New Drugs and Devices
Authors: Kaul Sanjay , Stockbridge Norman , Butler Javed
Published: November 2020

Balancing benefits and risks is a complex task that poses a major challenge, both to the approval of new medicines and devices by regulatory authorities and in therapeutic decision-making in practice. Several analysis methods and visualization tools have been developed to help evaluate and communicate whether the benefit–risk profile is favorable or unfavorable. In this White Paper, we describe approaches to benefit–risk assessment using qualitative approaches such as the Benefit Risk Action Team framework developed by the Pharmaceutical Research and Manufacturers of America, and the Benefit–Risk Framework developed by the United States Food and Drug Administration; and quantitative approaches such as the numbers needed to treat for benefit and harm, the benefit–risk ratio, and Incremental Net Benefit. We give illustrative examples of benefit–risk evaluations using 4 treatment interventions including sodium glucose cotransporter 2 inhibitors in patients with type 2 diabetes; a direct antithrombin agent, dabigatran, for reducing stroke and systemic embolism in patients with nonvalvular atrial fibrillation; transcatheter aortic valve replacement in patients with symptomatic severe aortic valve stenosis; and antiplatelet agents vorapaxar and prasugrel for reducing cardiovascular events in patients at high cardiovascular risk. Regular applications of structured benefit–risk assessment, whether qualitative, quantitative, or both, enabled by easy-to-understand graphical presentations that capture uncertainties around the benefit–risk metric, may aid shared decision-making and enhance transparency of those decisions.
Activation of the Sympathetic Nervous System Promotes Blood Pressure Salt-Sensitivity in C57BL6/J Mice
Authors: Ralph Ailsa F. , Grenier Celine , Costello Hannah M. , Stewart Kevin , Ivy Jessica R. , Dhaun Neeraj , Bailey Matthew A.
Published: November 2020

Global salt intake averages >8 g/person per day, over twice the limit advocated by the American Heart Association. Dietary salt excess leads to hypertension, and this partly mediates its poor health outcomes. In ≈30% of people, the hypertensive response to salt is exaggerated. This salt-sensitivity increases cardiovascular risk. Mechanistic cardiovascular research relies heavily on rodent models and the C57BL6/J mouse is the most widely used reference strain. We examined the effects of high salt intake on blood pressure, renal, and vascular function in the most commonly used and commercially available C57BL6/J mouse strain. Changing from control (0.3% Na
+
) to high salt (3% Na
+
) diet increased systolic blood pressure in male mice by ≈10 mm Hg within 4 days of dietary switch. This hypertensive response was maintained over the 3-week study period. Returning to control diet gradually reduced blood pressure back to baseline. High-salt diet caused a rapid and sustained downregulation in mRNA encoding renal
NHE3
(sodium-hydrogen-exchanger 3) and
EnaC
(epithelial sodium channel), although we did not observe a suppression in aldosterone until ≈7 days. During the development of salt-sensitivity, the acute pressure natriuresis relationship was augmented and neutral sodium balance was maintained throughout. High-salt diet increased ex vivo sensitivity of the renal artery to phenylephrine and increased urinary excretion of adrenaline, but not noradrenaline. The acute blood pressure–depressor effect of hexamethonium, a ganglionic blocker, was enhanced by high salt. Salt-sensitivity in commercially sourced C57BL6/J mice is attributable to sympathetic overactivity, increased adrenaline, and enhanced vascular sensitivity to alpha-adrenoreceptor activation and not sodium retention or attenuation of the acute pressure natriuresis response.