bluuebunny/crossref_metadata_2025 huggingface dataset:
Variations saisonnières des performances de reproduction des brebis Ouled Djellal dans la région de Chlef, Algérie
Authors: Zidane Azdinia , Taherti Mourad , Gadouche Leila , Metlef Sarra , Ababou Adda
Published: December 2021

La reproduction contribue directement à la rentabilité des élevages et les performances associées sont synthétisées dans des indicateurs économiques centraux dans l’analyse des performances globales des systèmes d’élevages. L’activité sexuelle et ainsi les performances reproductives des brebis sont affectées par des facteurs environnementaux, en premier lieu la photopériode. La brebis Ouled Djellal, naturellement davantage désaisonnée que d’autres races ovines, est peu sensible au facteur photopériodique, parvenant ainsi à maintenir des cycles sexuels pendant la majeure partie de l’année et exprimant peu d’anoestrus saisonnier. Les performances reproductives de cette race n’étant que partiellement exploitées, la présente étude a visé à les caractériser dans la région de Chlef, Algérie. Elle a concerné 834 brebis Ouled Djellal réparties dans 20 exploitations localisées dans différentes communes avec 417 brebis pour chaque saison. Les brebis étaient âgées de trois à cinq ans, et soumises à la photopériode et aux températures naturelles. Les paramètres reproductifs analysés à l’automne et au printemps ont été les taux de fertilité, de fécondité, de prolificité, de productivité numérique et de mortalités. A l’exception des mortalités qui ont montré une différence non significative entre l’automne et le printemps, les résultats sur les autres paramètres de performance ont mis en évidence une différence très significative (p < 0,0001) entre les deux saisons. Malgré ces différences entre saisons, dont les origines sont discutées, les performances reproductives analysées ont été globalement encourageantes pour améliorer la rentabilité des élevages de cette race.
Unmanned aerial vehicle for the assessment of woody and herbaceous phytomass in Sahelian savanna
Authors: Bossoukpe Marina , Ndiaye Ousmane , Diatta Ousmane , Diatta Sékouna , Audebert Alain , Couteron Pierre , Leroux Louise , Diouf Abdoul Aziz , Dendoncker Morgane , Faye Emile , Taugourdeau Simon
Published: December 2021

The phytomass of herbaceous and woody plants is the main source of feed for pastoral livestock in the Sahelian savanna. The assessment of the available feedstock plays a key role in national livestock policies and generally requires many field measurements of both herbaceous and woody plants. In this study, we tested the possibility of using a red-green-blue (RGB) unmanned aerial vehicle (UAV) to evaluate the phytomass of both woody and herbaceous species. We thus mapped 38 one hectare plots with a Dji Spark UAV in Northern Senegal. The herbaceous phytomass was measured on the ground. For the woody communities, we evaluated the leaf phytomass using dendrometric parameters combined with allometric equations. We performed partial-least square regressions between UAV-based three-dimension and color indices and phytomass. Results showed a Q² (cross validation results for each response variable) of 0.57 for woody phytomass, 0.68 for herbaceous dry mass, and 0.76 for their fresh mass. This study confirmed the relevance of using low-cost RGB UAV to assess savanna phytomass.
Mais fontes de informação especializada em africanidades
Authors: Carvalho Wellington Marçal de , Rezende Angerlânia , Gomes Gracielle Mendonça Rodrigues
Published: December 2021

Introdução: As fontes de informação especializada são artefatos construídos por seres humanos que agenciam uma série de elementos informacionais sobre determinado recorte / especialidade da existência cotidiana. Esses artefatos se prestam a sanar uma demanda informacional específica e, não obrigatoriamente, podem apontar novos caminhos em virtude do que resultar o ato de compulsar esses mecanismos. Objetivo: Apresentar novo conjunto de fontes de informação especializada em africanidades almejando contribuir para ampliar o conhecimento sobre a existência dessas fontes através da reunião de informações essenciais sobre cada uma delas, mediante parâmetros biblioteconômicos. Método: Os procedimentos metodológicos adotados foram: a) contato com pesquisadores do campo das africanidades; b) identificação de textos teóricos para delimitação do conceito africanidades; c) verificação da disponibilidade de acesso às fontes; d) recolha de informações para descrição das fontes de informação selecionadas; e) agrupamento, quando possível, das fontes por área temática; e f) consolidação dos resultados em forma de guia de fontes. Resultados: Foram identificadas, reunidas e descritas 23 fontes de informação, distribuídas em cinco categorias. Conclusão: Acredita-se que o rol de artefatos informacionais apresentado funciona como um estratégico guia a subsidiar o fortalecimento de epistemologias novas e radicais, fundamentadas em preceitos éticos e acolhedores dos saberes erigidos, prioritariamente, em espaços contra-hegemônicos.
Exploration Study Of The Impact Of Working From Home (Wfh) On Employee Performance During The Covid-19 Pandemic
Authors: Dharma Pramadhi
Published: December 2021

Currently, many countries around the globe including Indonesia are hugely affected by a novel pandemic COVID-19. This pandemic has impacted the economic and social sectors as well as caused dramatic changes in work patterns. Many employees are forced to shift their current working style from the office to work from home (WFH). This study aims to determine the impact of WFH on employee performance and to provide information regarding the advantages and disadvantages of WFH during the COVID-19 pandemic from the employee perspective. This exploratory study used the descriptive method and the data were obtained from the responses of 75 employees that are currently on WFH at different sectors in Surabaya. Evidently, 63% of the respondents are private employees, followed by 33% of them belongs to government employees, and 4% of employees have their state-owned enterprises. There were 83% of employees who experiences WFH due to the prevention of spreading COVID-19 transmission. The analysis of the work performance revealed that 47% of the respondents did not experience any differences between WFH and conventional office’s working style. In addition, 29% of employees expressed their opinion regarding the decrease in productivity level during WFH, and 20% of them admitted that their performance level elevated during WFH. In fact, based on the employees’ opinions, the biggest advantages of WFH include flexible working hours, efficient personal budget cuts for transportation costs, and more quality time to spend with families. However, the disadvantages of WHF are the increase in internet and electricity cost, some tasks from work that could not be performed at home such as scientific laboratory experiments, and the lack of focus to work properly due to distraction at home especially if they have their children around all time. Furthermore, even though work from home was accepted by most employees, but according to some correspondents’ opinions, the current WFH trend was not ideal for many different types of jobs.
Strategi Pendidik Dalam Pembelajaran Anak Usia Dini Saat Pandemi Covid 19
Authors: Dewi Rahayu Firta
Published: December 2021

Pandemi Coronavirus 2019 (COVID-19) telah menciptakan tantangan bagi komunitas pendidikan global. Sebagai upaya alternatif, banyak lembaga pendidikan yang  mengembangkan protokol belajar mengajar secara online. Tujuan dari penelitian ini adalah untuk mengetahui strategi yang dilakukan oleh tebaga pendidik dalam mengoptimalkan mutu pendidikan anak usia dini di masa pandemic agar anak tetap memperoleh kualitas pendidikan yang baik dengan situasi belajar yang menyenangkan. Peneliti  menggukan metode  studi  literatur  dengan  cara  mengumpulkan  literature bahan-bahan  materi  yang  bersumber  dari  buku,  jurnal,  dan sumber  lainnya  yang  berkaitan  dengan  strategi dalam pembelajaran anak usia dini. Selama masa lockdown, proses penugasan, kegiatan Home Visit, dan juga laporan kegiatan harian anak menjadi solusi penting dalam pelaksanaan proses kegiatan belajar anak selama pandemi covid-19. Hal ini bertujuan agar semua aspek perkembangan anak dapat berkembang dengan baik sesuai dengan capaian perkembangan anak. Orang tua, guru, stakeholder lembaga pendidikan anak usia dini memiliki andil besar dalam menciptakan pembelajaran yang positif selama pandemic
Radioterapi Kanker Cervix Dengan Linear Accelerator (LINAC)
Authors: Winarno Winarno
Published: December 2021

Kanker serviks merupakan salah satu kanker mematikan yang sering terjadi di Indonesia. Pada tahun 2019, Kementerian Kesehatan mencatat kanker serviks menempati peringkat kedua untuk jenis kanker yang paling banyak ditemui setelah kanker payudara. Setiap tahunnya, ada sekitar 40.000 kasus baru kanker serviks yang terdeteksi pada perempuan Indonesia. Upaya dalam menyembuhkannya melalui radioterapi dengan radiasi pengion yang untuk mematikan sel kanker. Sumber yang digunakan adalah sinar X atau foton. Salah satu jenis pesawat radioterapi eksternal adalah Akselerator Linear (Linac). Dalam melakukan kalibrasi alat – alat radioterapi khususnya LINAC dan dalam melakukan treatment planning system (TPS) pada kanker memerlukan seorang fisikawan medis. Observasi dilakukan dengan tahapan orientasi, observasi langsung, hingga konsultasi dan diskusi. Peran fisikawan medis meliputi perencanaan TPS, simulasi pada kanker pasien, pembuatan blok untuk melindungi organ sehat, perhitungan dosis serta melakukan penyinaran. Pentingnya peran seorang fisikawan medis dalam proses radioterapi untuk mengobati kanker serviks.
A Rare Case of Chronic Primary Angle-Closure Glaucoma in a Young Woman with Coexisting Pathologic Myopia
Authors: Dhiyantari Ni Putu Ayu Reza , Nurwasis Nurwasis , Komaratih Evelyn , Primitasari Yulia
Published: December 2021

Introduction: Primary Angle-Closure Glaucoma (PACG) is usually present in adults older than forty and is more common in hyperopic eyes. Angle-closure is usually related to structural or developmental ocular abnormalities in young individuals. Case presentation: We presented a rare case of PACG in a 32 years old woman with pathologic myopia of -23.0 RLE. The chief complaint was blurring of the right eye three months before the visit. Right eye Intraocular Pressure (IOP) was 30mmHg-38mmHg despite treatment with three intra-ocular pressure-lowering agents. Axial length was 32.36 mm and 31.19 mm RLE. Anterior chamber depth was 2.36 mm and 2.60 mm RLE. Lens thickness was 5.07 mm and 5.40 mm RLE. Signs of GON and pathologic myopia were found in both eyes. GON was present asymmetrically (0.9 and 0.6 RLE), with the myopic crescent as well as baring and peripapillary atrophy. The optic disc was slightly tilted with the myopic crescent. There was also a marked sign of retinal pigment epithelium thinning and attenuation along with myopic chorioretinal atrophy. Conclusions: PACG in a young myopic individual is challenging to diagnose because myopia and glaucoma share similar optic nerve head pathology. Comprehensive examinations including gonioscopy, biometry, and OCT may confirm the diagnosis. In the presented case, angle-closure was caused by thick lenses and a shallow anterior chamber, along with excessively long axial length. Primary angle-closure at a young individual with myopic eyes is highly uncommon. Nonetheless, clinicians should always consider glaucoma even in the presence of high axial length and myopic fundus.
SPİNOZA ONTOLOJİSİ BAĞLAMINDA YAPAY ZEKÂ VE BİR DUYGU VARLIĞI OLAN İNSAN ÜZERİNE BİR DEĞERLENDİRME
Authors: GÜLTEKİN Abdurrazak , ÇELEBİ Emin
Published: December 2021

Günümüzde yapay zekâ çalışmaları ile birlikte yepyeni bir ontolojik paradigmanın eşiğine geldiğimiz açıktır. Varlık, bilgi ve değer döngüsünde vücut bulan bu değişimlerden en çok etkilenen ise kuşkusuz hem özne hem de nesne rolünü ifa eden insandır. İnsanın kendisine rakip olabilecek gelişmelere imza atan yapay zekâ teknolojilerinin felsefi olarak değerlendirilmesi gerekliliği önümüzde durmaktadır. Ne var ki düşünce tarihinde bu konunun felsefi bir perspektifle değerlendirmeye imkân veren klasik ontolojilerin varlığı oldukça sınırlıdır. Bu bağlamda öne çıkan ontolojilerden biri bize göre Spinoza’nın mekanik, deterministik ve monist ontolojisidir. Bu çalışmada Spinoza ontolojisinin karakteristiği ile yapay zekâ ontolojilerinin paralellik arz ettiği ileri sürülecek ve söz konusu zorunluluğun bir duygu varlığı olan insanın özgürlük ve eylemsellik durumunu da kapsadığına vurgu yapılacaktır.
ASSESSING HOLIDAY SATISFACTION OF GERMAN AND RUSSIAN TOURISTS VISITING ALANYA
Authors: Aktaş Ahmet , Çevirgen Aydın , Toker Boran
Published: December 2021

This study attempts to explore the tourists’ satisfaction within a tourism context, specifically with reference to the destination-based attributes. The study was conducted in Alanya with a sample of German and Russian tourists. Gathering data was analyzed using factor and regression analysis and t-tests. The research findings indicated that the dimension of accommodation services was the strongest predictor of the German tourists’ satisfaction, followed by incoming travel agency services and facilities of Alanya. The dimension of accommodation services also was the strongest predictor of the Russian tourists’ overall holiday satisfaction, followed by destination facilities and incoming travel agency services. Moreover, the mean scores of all the items within the three dimensions were above the neutral point. These results revealed that both Germans and Russians were generally satisfied with their holiday in Alanya.
HUMAN RESOURCES DEVELOPMENT OF REPUBLIC OF CROATIA AND PRIMORSKOGORANSKA COUNTY AND THEIR INFLUENCE ON ECONOMIC GROWTH∗
Authors: Karaman Aksentijevic Nada , Jezic Zoran
Published: December 2021

In the theoretical part of research authors will establish connections and diversities between human capital and human resources categories. In the empirical part of research, via HDI, it will be evaluated the development of human resources in Republic Of Croatia and in Primorsko-goranska County and in will be evaluated relation between HDI and GDP per capita of Croatia and in Primorsko-goranska County. Authors will also analyze how much development of human resources has contributed to the economic growth of Republic Of Croatia. In order to demonstrate this it will be measured influence of investment, employment and educational structures (the indirect indicator of development of human resources) on the growth of GDP in the period of 1997-2005 with usage of regression analyses.
MARKETING ASPECTS IN THE OPERATIONS OF THE VELEBIT NATURE PARK
Authors: Berc Radisic Branka , Bašan Lorena , Bokulić Diana
Published: December 2021

The application of marketing in tourism involves marketing activities undertaken by all producers that are in any way connected to selling their products on the tourist market, as a means of earning revenue. Tourism marketing calls for a marketing concept to be implemented in companies in the tourism sector and other tourism-supply providers. Upon the adoption of the Management Plan of the Velebit Nature Park, a marketing concept, as an element of efficient park management, must be employed to help ensure the prosperity of Park operations in all areas and across all levels.
REPOSITIONING OF THERMAL SPA TOURISM OF NORTH-WEST CROATIA IN ACCORDANCE WITH THE EUROPEAN THERMAL SPA TOURISM TRENDS
Authors: Alkier Radnić Romina , Gračan Daniela , Fister Maja
Published: December 2021

: Tourism represents an important originator of economic activities in Croatia, particularly in its seaside destinations. However, it is developed quite unevenly. The overall Croatian territory can be divided into three different natural and geographic regions, with different levels in tourism development: lowland or Pannonian and peripannonian Croatia, highland Croatia, and seaside Croatia. From the tourism development point of view, lowland and highland Croatia have been neglected, and therefore their comparative advantages have not been used to their advantage or not used at all because of the lack of interest in local inhabitants and poorly educated economists. Thermal spa tourism of North-West Croatia has been developing for a long time, so nowadays thermal sources of Krapinske, Stubicke, Tuheljske, Varazdinske, and Sutinske spas are situated in the area. All those thermal spas have natural prerogatives for tourism development, but their tourism product is outworn and has lost its quality and attraction it had in the past. Therefore the repositioning of tourism product of the area is necessary in order to make it desirable in the tourist markets of both Croatia and Europe.
REAL WAGES AS DETERMINANT OF LABOUR PRODUCTIVITY IN TOURISM
Authors: Chaido Dritsaki
Published: December 2021

This paper examines the effect of real wages on labour productivity for the case of tourist sector. Since, tourist sector is widely a service-oriented sector based on personal employment characteristics, we propose a theoretical model of Cobb – Douglas productivity equation which accounts only for labor. The paper aims at calculating the productivity-income elasticity of tourist sector based on the aforementioned model.
Primary ovarian insufficiency: from basis of pathogenesis to treatment perspectives
Authors:   National Medical Research Center for Endocrinology, Moscow, Russian Federation, Andreeva E.N. ,   A.I.Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Absatarova Yu.S. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation, Akhmatova R.R. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation, Sheremetieva E.V. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation, Mikheev R.K. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation, Grigoryan O.R. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation
Published: December 2021

The review of literature data on primary ovarian insufficiency (POI), its autoimmune aspect, determination of markers for early diagnosis of the disease, treatment options and implementation of reproductive plans was carried out. Autoimmune and genetic aspects of pathogenesis, markers of autoimmunity in ovarian tissue, which may be promising for early diagnosis in risk groups of patients with autoimmune pathology, were considered; information on the incidence of nosology in other autoimmune diseases, which will also allow to identify POI at early stages, was provided. This article provides information about a new direction in reproductive surgery – drug-free in vitro activation based on primordial follicle activation by modulating biological signaling pathways. This procedure may have a long-term perspective for realizing reproductive potential without the use of donor eggs. The literature search was performed in domestic (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The selection of sources was made within a limited period from 2016 to 2021. However, given the insufficient knowledge of the chosen topic, the selection of sources was dated from 2009. Key words: autoimmune oophoritis, hypergonadotropic hypogonadism, primary ovarian insufficiency, in vitro activation
The intervention models to alleviate stress among mothers of premature babies in the NICU: a systematic review
Authors:   Nursing Faculty, Sultan Agung Islamic University, Semarang, Indonesia, Khasanah N.N. ,   Nursing Faculty, Universitas Indonesia, Depok, Indonesia, Rustina Y. ,   Nursing Faculty, Universitas Indonesia, Depok, Indonesia, Hariyati T.S. ,   Nursing Faculty, Universitas Indonesia, Depok, Indonesia
Published: December 2021

Objective. This systematic review was conducted to evaluate the effectiveness of the intervention model in the Neonatal Intensive Care Unit (NICU) environment to reduce the stress levels in mothers during the treatment of their premature babies in the NICU. Methods. A literature search was conducted through CINAHL, Springer Nature, ProQuest, SAGE, and Scopus in March 2021 with a total search result of 1338 articles. The inclusion criteria were experimental and quasi-experimental studies that analyzed the effect of the intervention on the stress among mothers of premature babies being treated in the NICU. Results. Five types of intervention modification reported in 10 articles matched the inclusion criteria (n = 1046 participants). In general, the type of intervention provided is based on education combined with a bio/psycho/socio/cultural/spiritual approach. Providing education with one of these approaches is considered more effective when compared to education only. Most interventions did not involve the father. Conclusion. Providing education through a comprehensive approach can be an alternative to reduce stress for mothers who have premature babies being treated in the NICU. Key words: intervention, mother, premature babies, stress
The Spillover Effect of the Medicare Mandatory Bundled Payment Program on Joint Replacement Outcomes
Authors: Kim Hyunjee , Hart Kyle D. , Meath Thomas H.A. , Zhu Jane M. , McConnell K. John
Published: December 2021

Background:

To improve the value and efficiency of care among traditional Medicare enrollees, the Centers for Medicare & Medicaid Services has implemented alternative payment models designed to control health-care spending and improve quality. These models may affect care beyond traditional Medicare enrollees, “spilling over” into other populations. Established in April 2016, the Medicare mandatory bundled payment program, called the Comprehensive Care for Joint Replacement (CJR) model, holds hospitals accountable for spending and quality of care for traditional Medicare joint-replacement patients during care episodes that span from the index hospitalization to 90 days post-discharge. We assessed the extent to which the CJR model was associated with outcomes for patients enrolled in commercial insurance and Medicare Advantage plans.

Methods:

With use of Health Care Cost Institute claims data from 2012 through 2017, we assessed the association of the CJR model with total expenditures, discharges to institutional post-acute care, and readmissions among commercial insurance and Medicare Advantage joint-replacement patients. The exposure variable was the implementation of the CJR model in 67 randomly selected metropolitan statistical areas compared with 103 similar areas without CJR implementation. We utilized difference-in-differences models to estimate the spillover effects of the CJR model by comparing outcomes between these areas before and after CJR implementation.

Results:

The study included 174,893 joint-replacement episodes of care in commercial insurance enrollees and 202,070 episodes in Medicare Advantage enrollees. Among both commercial insurance and Medicare Advantage enrollees, CJR implementation was associated with no meaningful changes in total episode expenditures, discharges to institutional post-acute care, or readmissions.

Conclusions:

We found no evidence for spillover effects of the CJR model on commercial insurance and Medicare Advantage patients, suggesting that alternative payment models targeting traditional Medicare patients may have limited effects on the cost and quality of care for patients outside of the traditional Medicare system.
Development and Internal Validation of Machine Learning Algorithms for Predicting Hyponatremia After TJA
Authors: Kunze Kyle N. , Sculco Peter K. , Zhong Haoyan , Memtsoudis Stavros G. , Ast Michael P. , Sculco Thomas P. , Jules-Elysee Kethy M.
Published: December 2021

Background:

The development of hyponatremia after total joint arthroplasty (TJA) may lead to several adverse events and is associated with prolonged inpatient length of stay as well as increased hospital costs. The purpose of this study was to develop and internally validate machine learning algorithms for predicting hyponatremia after TJA.

Methods:

A consecutive cohort of 30,703 TJA patients from an institutional registry at a large, tertiary academic hospital were included. A total of 19 potential predictor variables were collected. Hyponatremia was defined as a serum sodium concentration of <135 mEq/L. Five machine learning algorithms were developed using a training set and internally validated using an independent testing set. Algorithm performance was evaluated through discrimination, calibration, decision-curve analysis, and Brier score.

Results:

The charts of 30,703 patients undergoing TJA were reviewed. Of those patients, 5,480 (17.8%) developed hyponatremia postoperatively. A combination of 6 variables were demonstrated to optimize algorithm prediction: preoperative serum sodium concentration, age, intraoperative blood loss, procedure time, body mass index (BMI), and American Society of Anesthesiologists (ASA) score. Threshold values that were associated with greater hyponatremia risk were a preoperative serum sodium concentration of ≤138 mEq/L, an age of ≥73 years, an ASA score of >2, intraoperative blood loss of >407 mL, a BMI of ≤26 kg/m2, and a procedure time of >111 minutes. The stochastic gradient boosting (SGB) algorithm demonstrated the best performance (c-statistic: 0.75, calibration intercept: −0.02, calibration slope: 1.02, and Brier score: 0.12). This algorithm was turned into a tool that can provide real-time predictions (https://orthoapps.shinyapps.io/Hyponatremia_TJA/).

Conclusions:

The SGB algorithm demonstrated the best performance for predicting hyponatremia after TJA. The most important factors for predicting hyponatremia were preoperative serum sodium concentration, age, intraoperative blood loss, procedure time, BMI, and ASA score. A real-time hyponatremia risk calculator was developed, but it is imperative to perform external validation of this model prior to using this calculator in clinical practice.

Level of Evidence:

Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Influencia de la arquitectura vernácula en las bodegas de vino mexicanas
Authors: Fernandez Barberena Maria Jose
Published: December 2021

Al vivir el ser humano en un lugar fijo, construyó ciertos espacios para cubrir sus necesidades, por lo que buscó emplear recursos naturales a su alcance, como adobe, madera, piedras, tierra y variados elementos vegetales y aún animales con técnicas sencillas. Este tipo de construcción es primigenia de la humanidad y en su composición y forma manifiesta las necesidades de supervivencia básicas del ser humano, se acopla a su entorno y a la cultura a la que pertenece. Sus técnicas de construcción se fueron ajustando a los materiales disponibles, a la adaptación de la mano de obra y a las herramientas a su alcance y, por otro lado, a los desastres naturales como inundaciones, incendios o sismos que los forzaron a adecuarse.

 En la actualidad se le está dando importancia a las edificaciones vernáculas y son objeto de estudio; de tal manera que muchos arquitectos contemporáneos están retomando el concepto con el fin de recuperar los valores arquitectónicos de una región y construir aprovechando los recursos disponibles, adaptándose al medio físico. En este trabajo se pretende profundizar en el concepto de arquitectura vernácula y los elementos que la conforman, de forma que se pueda identificar las características vernáculas que han influido en la arquitectura contemporánea de algunos viñedos en México.
El triunfo de la Inmaculada Concepción de Andrea Andreoli para Cádiz
Authors: Maura Alarcón Carlos , De la Cruz Sastre Antonio
Published: December 2021

En el presente artículo, profundizamos en el conocimiento del triunfo de la Inmaculada Concepción de Cádiz, a raíz de la reciente reaparación de su contrato de ejecución en el archivo histórico de la Archicofradía de la Palma, a los que sumamos otros documentos inéditos en relación con su proceso constructivo. Sus modelos de referencia y las consecuencias de su erección ocuparán la segunda parte del mismo, donde plantearemos una posible explicación acerca del éxito de su tipología en la ciudad.
A Proposed Method for Residual Citation Allocation Based on Citation Contexts’ Similarity
Authors: Asubiaro Toluwase Victor , Ajiferuke Isola
Published: December 2021

This article proposes an approach for allocating residual citations to scientific publications and demonstrating this proposed approach with a sample of biomedical publications. Residue citations (i.e., citations that are lost due to citation practices termed “Obliteration by Incorporation” and the “Palimpsestic Syndrome”) in consequent citations in the second, third or nth generations are then reconstituted. The proposed approach takes into account citation contexts (i.e., the contribution of a cited publication) for allocating residual citation. The proposed method for allocating residual citation is based on the similarity between the citation contexts of a publication and those of its nth generation citations in their n+1th generation citations. The proposed method was demonstrated using a sample with ten base articles and their five generations of citations, from which 5,272 citation context pairs were obtained. The proposed indirect citation weighting was compared with the existing cascading citation weighting method using one T-test. Statistical tests were also performed to understand the differences in the residual citations from one generation to the other. Like the cascading citation system, residual citations from articles to their generations of citations decreased as the number of generations increased. However, residue citations accrued to publications at all the generations were statistically different between the proposed residual citation and the cascading citation system. This study proposes a method for assessing scientific communication based on the contribution of scientific publications beyond the conventional direct citation.
Early Onset of Intrahepatic Cholestasis of Pregnancy: a Case Report
Authors: Stavinskaia Liudmila , Cemortan Maria , Cernetchi Olga
Published: December 2021

Intrahepatic cholestasis of pregnancy is a disorder, characterized by pruritus and elevated liver function tests. Associated with a high incidence of adverse perinatal outcomes, intrahepatic cholestasis of pregnancy (ICP) requires thorough attention in clinical practice. In addition, there is a high rate of stillbirth in cases of ICP. Women with ICP should be informed of the inability to predict stillbirth. Multi-disciplinary cooperation is critical for managing the condition and ensuring better pregnancy outcomes.
Nonlinear Error Compensation Based on the Optimization of Swing Cutter Trajectory for Five-Axis Machining
Authors: Chen Liangji , Tang Jinmeng , Wu Wenyi , Wei Zisen
Published: December 2021

In order to solve the problem of deviation between actual and theoretical machining paths due to the presence of rotation axis in five-axis machining, an interpolation algorithm based on the optimization of swing cutter trajectory and the method of corresponding nonlinear error compensation are proposed. Taking A-C dual rotary table five-axis machine tool as an example, the forward and reverse kinematic model of the machine tool is established according to the kinematic chain of the machine tool. Based on the linear interpolation of rotary axis, the generation mechanism of nonlinear error is analyzed, the modeling methods of cutter center point and cutter axis vector trajectory are proposed respectively, and the parameterized model of swing cutter trajectory is formed. The formula for the nonlinear error is obtained from the two-dimensional cutter center point trajectory. According to the established model of swing cutter trajectory, the synchronous optimization method of cutter center point trajectory and cutter axis vector trajectory is proposed, and the nonlinear error compensation mechanism is established. First, pre-interpolation is performed on the given cutter location data to obtain a model of the swing cutter trajectory for each interpolated segment. Then the magnitude of the nonlinear error is calculated based on the parameters of the actual interpolation points during formal interpolation, and the interpolation points with large errors are compensated for the nonlinear error. The simulation results show that the proposed method can effectively reduce the impact of nonlinear errors on machining, and is of high practical value for improving the accuracy of cutter position and the quality of complex free-form machining in five-axis machining.
Ligand-specific conformational change drives interdomain allostery in Pin1
Authors: Vogeli Beat , Born Alexandra , Soetbeer Janne , Henen Morkos , Breitgoff Frauke , Polyhach Yevhen , Jeschke Gunnar
Published: December 2021

Pin1 is a two-domain cell regulator that isomerizes peptidyl-prolines. The catalytic domain (PPIase) and the other ligand-binding domain (WW) sample extended and compact conformations. Ligand binding changes the equilibrium of the interdomain conformations, but the conformational changes that lead to the altered domain sampling were unknown. Prior evidence has supported an interdomain allosteric mechanism. We recently introduced a magnetic resonance-based protocol that allowed us to determine the coupling of intra- and interdomain structural sampling in apo Pin1. Here, we describe ligand-specific conformational changes that occur upon binding of pCDC25c and FFpSPR. pCDC25c binding doubles the population of the extended states compared to the virtually identical populations of the apo and FFpSPR-bound forms. pCDC25c binding to the WW domain triggers conformational changes to propagate via the interdomain interface to the catalytic site, while FFpSPR binding displaces a helix in the PPIase that leads to repositioning of the PPIase catalytic loop.
P. Falciparum Community Prevalence and Health Seeking Behaviors in Rural Sussundenga District, Mozambique
Authors: Earland Dominique E , Bibe Albino Francisco , Novela Anísio , Ferrão João , Searle Kelly M
Published: December 2021

Background: The large-scale effectiveness of malaria control interventions is differential at international border settings with varying policies, such as that between Mozambique and Zimbabwe. Impacts of nationally directed malaria control interventions hinge on understanding malaria transmission and prevention at the community level along international borders. Thus far, few studies have focused on central Mozambique. Our aim was to describe community level P. falciparum transmission dynamics and health seeking behaviors among residents of Sussundenga, Mozambique, a rural village bordering Zimbabwe in Manica Province with high malaria incidence reported at the Sussundenga-Sede health center (RHC). Methods: We conducted a cross-sectional community-based survey from December 2019 – February 2020. We used a random household sampling method, based on enumerated households from satellite imagery. All consenting participants completed a survey about malaria risk, prevention, and health seeking-behaviors, and received a P. falciparum malaria rapid diagnostic test (RDT). Results: We enrolled 96 households with 358 individuals. The P. falciparum prevalence was 31.6% (95% CI [26.6-36.5]). Ninety-three percent of participants reported using the Sussundenga-Sede RHC for healthcare. Sixty-six percent of participants (N=233) experienced at least one malaria symptom in the past month, with self-reported fever most frequently reported (19.3%). Of these, 176 (76.5%) sought care in a health facility and 174 (79%) received an RDT with 130 (63%) positive results. Of those with a positive RDT, 127 (97%) received Coartem®. Following treatment, 123 (97%) participants' symptoms resolved within a median of 3 days (IQR: 3-5) ranging from 2-14 days. In this high transmission setting, a high proportion of participants recognized malaria related symptoms then received a proper diagnostic test and treatment in a health facility. Conclusions: Future interventions that leverage this health seeking behavior and strengthen health systems for community interventions will improve malaria control and inform the efficacy of potential interventions at this particular international border.
Understanding Drivers of Vaccine Hesitancy among Pregnant Women in Nigeria: A Longitudinal Study
Authors: Adeyanju Gbadebo , Betsch Cornelia , Sprengholz Philipp
Published: December 2021

Background: Vaccine-preventable diseases are major contributors to the disease burden in Sub-Saharan Africa, accounting for many childhood illnesses, disabilities, and mortality. There is dearth of knowledge on the drivers of vaccine hesitancy in Nigeria and the extent of its impact on coverage. Pregnant women are a particularly important vulnerable and at-risk group and, additionally, very relevant for childhood vaccination decisions. However, this group is understudied in Nigeria. This study’s aims are to adapt Confidence, Complacency, Constraints, Calculation, and Collective Responsibility, also known as the 5C psychological antecedence scale for the Nigerian context and to measure vaccine hesitancy to predict the intention to vaccinate among pregnant women (prenatal) and subsequent vaccination behavior (postnatal). Method: It is a longitudinal study that used multi-stage sampling procedure. One healthcare facility was selected from each district in five regional clusters, from which 255 pregnant women were randomly drawn. A standardized questionnaire was used to collect data on demographic characteristics, sources of vaccination information, and the 5C psychological antecedents of vaccination. Additional variables tested included the importance of religion, masculinity, and rumor/conspiracy theory. The scale’s reliability was explored, and a backward elimination regression analysis was performed to identify the major determinants of childhood vaccination intention among pregnant women (T1) and their postnatal behavior (T2). Results: The prenatal (T1) findings revealed low reliability of the 5C subscales in Nigeria’s setting. Pregnant women’s intention to vaccinate unborn children was lower if they were Muslims, had lower confidence in public authorities or the health system, if husband approval was important for vaccination, and if they believed in rumor. Postnatal (T2) findings revealed that vaccination was more likely to follow mothers’ religious beliefs, when confidence in vaccine effectiveness was high and when mothers felt responsible for the collective. However, higher levels of everyday stress (constraints) were related to less vaccination behavior, and intention did not predict actual vaccination behavior. Conclusion: The 5C scale is incompletely adaptable in Nigeria but is a better tool for measuring vaccination behavior than intention. Overall, the vaccination intention did not predict behavior among pregnant women. The additional variables are good instruments that need further exploration.
Homogeneous Surrogate Virus Neutralization Assay to Rapidly Assess Neutralization Activity of Anti-SARS-CoV-2 Antibodies
Authors: Kim Sun Jin , Yao Zhong , Marsh Morgan , Eckert Debra , Kay Michael , Lyakisheva Anna , Pasic Maria , Bansal Aiyush , Birnboim Hyman , Jha Prabhat , Delgado Julio , Elgort Marc , Campbell Robert , Middleton Elizabeth , Stagljar Igor , Owen Shawn
Published: December 2021

The COVID-19 pandemic triggered the development of numerous diagnostic tools to monitor infection and to determine immune response. Although assays to measure binding antibodies against SARS-CoV-2 are widely available, more specific tests measuring neutralization activities of antibodies are immediately needed to quantify the extent and duration of protection that results from infection or vaccination. We previously developed a ‘Serological Assay based on a Tri-part split-NanoLuc® (SATiN)’ to detect antibodies that bind to the spike (S) protein of SARS-CoV-2. Herein, we expand on our previous work and describe a reconfigured version of the SATiN assay that can measure neutralization activity of antibodies directly from convalescent or vaccinated sera. The sensitivity is comparable to cell-based pseudovirus neutralization assays but with significantly shorter preparation and assay run time. As the assay is modular, we further demonstrate that Neutralization SATiN (Neu-SATiN) enables rapid assessment of the effectiveness of vaccines and level of protection against existing SARS-CoV-2 variants of concern and can therefore be readily adapted for emerging variants.
Automatic Air Volume Control System for Ventilation of Two Patients Using a Single Ventilator: A Large Animal Model Study
Authors: Zielinski Krzysztof , Lisowska Barbara , Siewruk Katarzyna , Sady Maria , Ferenc Karolina , Barwijuk Maciej , Olszewski Jaroslaw , Anusz Krzysztof , Jablonski Artur , Gajewska Magdalena , Okrzeja Piotr , Michnikowski Marcin , Pijanowska Dorota , Pluta Krzysztof , Remiszewska Elzbieta , Darowski Marek , Zabielski Romuald , Liebert Adam , Kramek-Romanowska Katarzyna , Stecka Anna , Kozarski Maciej , Pasledni Raman , Gajewski Zdzislaw , Ladyzynski Piotr
Published: December 2021

The COVID-19 pandemic outbreak led to a global ventilator shortage. Hence, different strategies to use a single ventilator to support multiple patients are considered. A mechatronic system Ventil divides and automatically controls gas volume pumped through two channels and was successfully validated in independent lung ventilation. We used Ventil in a series of experiments on a large animal model to verify its usability for ventilation in two patients using a single ventilator. The results of investigations on 12 pigs showed that the physiological level of respiratory parameters was maintained for 24 hours. Application of Ventil did not lead to injuries in the lungs, as indicated by CT scan analysis. We conclude that ventilation using Ventil can be considered safe in patients subjected to deep sedation without spontaneous breathing efforts.
Initial Succession After Wildfire in Dry Boreal Forests of Northwestern North America
Authors: Dawe Denyse , Parisien Marc-André , Dongen Angeline Van , Whitman Ellen
Published: December 2021

Wildfires in the boreal forest of North America are generally stand renewing, with the initial phase of vegetation recovery often governing the vegetation trajectory for decades. Here, we investigate post-fire vegetation changes in dry boreal forests of the Northwest Territories, Canada, during the first five years following the unusually severe 2014 wildfire season. We sampled post-fire tree regeneration and the overall plant community at one, three, and five years post-fire across different fire severities and stand types within fires that burned in 2014. Post-fire trajectories of tree recruitment, cover by plant functional types, and plant diversity varied widely among sampled stands, as well as among years post-fire. Tree seedling density reaches relative equilibrium by three years post-fire, whereas trends in understory plant cover and understory species assemblages suggest an ongoing change that will extend beyond five years of observation. In almost half of sampled stands, the composition of recruited trees differs from that of the pre-fire stand, suggesting a change in tree-species dominance. An analysis of regional climate reveals a significant, albeit spatially variable, warming and drying trend that will further accelerate forest-stand transformation through both climate drivers of plant community composition and indirectly through increasing fire activity. While the 2014 wildfires enhanced the structural and compositional heterogeneity of the region, they also triggered vegetation changes that are likely to be persistent. As such, this study exemplifies the speed and variability that characterizes post-fire stand development in a strongly moisture-limited part of North America.
Treatment Outcome of Tardy Ulnar Nerve Palsy Associated with Traumatic Cubitus Valgus by Supracondylar Shortening Wedge Rotary Osteotomy and Ulnar Nerve in Situ Tension Release
Authors: Fan Chenchen , Yushan Maimaiaili , Liu Yanshi , Bahesutihan Yemenlehan , Liu Kai , Yusufu Aihemaitijiang
Published: December 2021

Background
Tardy ulnar nerve palsy is a common late complication of traumatic cubitus valgus. At present, the treatment of tardy ulnar nerve palsy associated with traumatic cubitus valgus is still controversial, whether these two problems can be corrected safely and effectively in one operation is still unclear. To investigate the supracondylar shortening wedge rotary osteotomy combined with in situ tension release of the ulnar nerve in the treatment of tardy ulnar nerve palsy associated with traumatic cubitus valgus.
Methods
Between 2012 and 2019, 16 patients who had traumatic cubitus valgus deformities with tardy ulnar nerve palsy were treated with simultaneous supracondylar shortening wedge rotary osteotomy and ulnar nerve in situ tension release. we compared a series of indicators of preoperative and postoperative follow-up for at least 24 months, (1) elbow range of motion; (2) the radiographic correction of the preoperative and postoperative humerus-elbow-wrist angles; (3) the static two-point discrimination and grip strength; and (4) the preoperative and postoperative DASH scores of upper limb function. The minimum follow-up was 24 months postoperative (mean, 33 months; range, 24ཞ44 months).
Results
The mean ROM was improved from 107 ° preoperatively to 122 ° postoperatively (P = 0.001). The mean preoperative elbow wrist angle was 24.6 °, and the mean postoperative humerus-elbow wrist angle was 12.1 ° (P < 0.001). The average grip strength and static two-point discrimination improved from 28 kg force and 8 mm to 21 kg force and 4.0 mm (P < 0.001 and P < 0.001, respectively). The ulnar nerve symptoms were improved in all patients except one. The mean HASH score improved from 29 to 16 (P < 0.001).
Conclusion
Supracondylar shortening wedge rotary osteotomy combined with in situ tension release of ulnar nerve is an effective method for the treatment of traumatic cubitus valgus with tardy ulnar nerve palsy, which restored the normal biomechanical characteristics of the affected limb and improved the elbow joint function.
N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA
Authors: Zhang Xiang , Yin Huilong , Zhang Xiaofang , Jiang Xunliang , Liu Yongkang , Peng Yingran , Li Da , Yu Yanping , Zhang Jinbao , Cheng Shuli , Yang Angang , Zhang Rui
Published: December 2021

Hepatic glycogen is the main source of blood glucose and controls the intervals between meals in mammals. Hepatic glycogen storage in mammalian pups is insufficient compared to their adult counterparts; however, the detailed molecular mechanism is poorly understood. Here, we showed that, similar to glycogen storage pattern, N6-methyladenosine (m6A) modification in mRNAs gradually increases during the growth of mice in liver. Strikingly, in the liver-specific Mettl3 knockout mice, loss of m6A modification disrupts liver glycogen storage. On the mechanism, we screened and identified that glycogen synthase 2 (Gys2) plays a critical role in m6A-mediated regulation of liver glycogen storage. Furthermore, IGF2BP2, as a “reader” of m6A, stabilizes the mRNA of Gys2. More importantly, reconstitution of GYS2 rescues liver glycogenesis in Mettl3-cKO mice. Collectively, a METTL3-IGF2BP2-GYS2 axis, in which METTL3 and IGF2BP2 regulate glycogenesis as “writer” and “reader” respectively, plays a critical role on maintenance of liver glycogenesis in mammals.