bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated use of unconditional mining raw materials
Authors: Khudyakova L. I.
Published: January 2023

The development of the mining industry is accompanied by an increase in the volume of overburden, enclosing and substandard rocks located in dumps, which negatively affects the ecological situation. The purpose of this study is to establish a possibility and offer ways for the integrated use of mining raw materials. A number of experiments were conducted to achieve the goal. Using the methods of gravimetry and atomic absorption spectroscopy, the chemical analysis of basalts of the Baikal region was carried out; using the destructive method, physical and mechanical tests of the samples were performed. The possibility of using these rocks as a coarse aggregate for concrete was studied; the dependence of the strength of the materials on the chemical composition of crushed stone was established; in particular, it was determined that the addition of crushed stone with a high content of magnesium and iron oxides into the composition of concrete improves the mechanical properties of the samples. The rock acidity modulus was within the regulated limits, which indicates the possibility of obtaining high-quality melt that contributes to good fiber formation. The working temperature for the basalt melt and its relationship with the chemical and mineralogical composition of the basalts were established. Basalts which are of little use for producing concrete are high-quality raw materials for producing mineral fiber. It is possible to use mining raw materials in a complex way and reduce the amount of substandard rocks transferred to dumps, thereby improving the environmental situation in the areas of subsoil use.
Epithelial tumors of the thymus with pleural dissemination: the potential role of surgery
Authors: Pikin O. V. , Ryabov A. B. , Aleksandrov O. A. , Kolbanov K. I. , Glushko V. A. , Barmin V. V. , Bagrov V. A. , Martynova D. E.
Published: January 2023

Background. Pleural metastases of thymic epithelial tumors are detected in 5–7 % of patients at initial diagnosis and in 10 % of patients during a follow-up after radical surgery for the primary tumor. Partial pleuroectomy is the cornerstone of treatment strategy in this group of patients.

The aim of the study was to assess the role of surgery in the treatment of patients with thymic epithelial tumors with pleural dissemination.

Material and Methods. From January1, 2010 to June 30, 2021, 21 patients with thymic epithelial tumors (thymoma – 13, thymic cancer – 8) and pleural implants (stage IVA – 11, isolated pleural metastases as tumor progression after radical surgery – 10) underwent partial pleuroectomy with resection of the diaphragm and lung if necessary. Four patients underwent inthraoperative photodynamic therapy and another 4 patients received intrapleural hyperthermic chemotherapy.

Results. R0 resection was performed on 12 (57.2 %) patients. Postoperative complications were observed in 6 (28.6 %) patients. The mortality rate was 7.5 %. The overall 1-, 3- and 5-year survival rates were 78 % (95 % CI 61–95), 49 % (95 % CI 23–75), and 41 % (95 % CI 15–67), respectively. The median overall survival time was 29 months (95 % CI 0–60.6). Recurrence occurred in 10 (47.6 %) cases. One-year recurrence-free survival was 60 % (95 % CI 30–90). Independent negative predictors for overall survival were: thymic cancer, incomplete resection, presence of postoperative complications and local recurrence.

Conclusion. Surgery is the mainstay of treatment for patients with pleural metastases (stage IVA thymomas and recurrent thymomas). Metastasectomy of pleural implants will be suffcient to achieve a complete resection.
Microbiome, immune system and cancer: three sides of the one medal
Authors: Belyavskaya V. A. , Cherdyntseva N. V. , Kzhyshkovska J. G. , Litvyakov N. V.
Published: January 2023

Purpose of the study to analyze current ideas about the relationship between the microbiota (microbiome) and the human body in the aspect of cancer pathogenesis, ambivalent character of these interactions, and the role of the immune system and immunoinfammatory status that promotes carcinogenesis or prevents neoplastic processes.

Material and Methods. Literature search was carried out using Medline, Cochrane Library, Elibrary and PubMed systems, including publications over the last 7 years.

Results. The microbiota includes all communities of commensal, symbiotic, and pathogenic microorganisms: bacteria, fungi, archaea, and viruses that colonize the gastrointestinal tract and other organs and tissues. The microbiome is an important factor in cancer pathogenesis due to its involvement in the basic physiological functions of the host, such as digestion, development of the immune system, and modulation of endocrine functions. In the review, the influence of microbiota of different locations (gastrointestinal tract, breast, intravaginal tract) on the development and progression of breast, colorectal and cervical cancers was discussed. The role of the microbiome in cancer pathogenesis is realized by the participation in neoplastic transformation of the epithelium, regulation of tumor progression under conditions of manifested malignant process, and modifcation of the therapeutic effect of standard drugs, including the development of original probiotic-based anticancer agents. The study of the mechanisms of action of the microbiome in the host organism opens up prospects for the development of new approaches to cancer therapy. Particular attention was paid to the mechanisms of the immunomodulatory effect of the microbiota in terms of reducing the risk of malignancy, regulating tumor progression and participating in antitumor therapy. The clinical significance of determining pathogenetically significant microbial markers associated with the aggressive form of cancer, response to treatment and toxicity of therapy was discussed. Particular attention should be paid to the potential mechanisms of interaction between cancer – microbiome – probiotics, since the latter can provide modification of malignancy processes, exert an antitumor effect, and modulate the effectiveness of drug therapy. The feasibility of editing the microbiota by probiotics was considered, and antitumor properties (effects) of bacteria and strategies for modifying the microbiome for the prevention and treatment of cancer were discussed.
Glycodelin is a potential biomarker for malignant tumors
Authors: Mnikhovich M. V. , Shekhter M. A. , Bezuglova T. V. , Skafi K. Kh. , Artemyeva K. A. , Mishina E. S.
Published: January 2023

Objective of the study to analyze and summarize the available data on the role of glycodelin in carcinogenesis and its expression in various cancers.

Material and Methods. A literature search was conducted in Medline, PubMed Central, NCBI databases in the time interval from January 1983 to October 2019 using the key words glycodelin and cancer. Of the 104 publications found, 21 were used to write the review.

Results. This paper presents the overview of the findings in current research focusing on the properties of glycodelin, the major lipocalin protein of the human reproductive system. Some lipocalins are known to play a key role in cancer development as well as influence signaling pathways in the regulation of cell motility, differentiation and neovascularization. Most likely they can be used as cancer markers. Glycodelin A is determined in serum and, due to its special immunoregulatory properties, can serve as a useful prognostic marker and a promising target for future anti-cancer therapies. The presence of glycodelin A in breast cancer tissue is known to be mostly linked to a better prognosis than is attributed to glycodelin-negative tissue, as glycodelin is a protein typical of differentiated tissue. On the other hand, glycodelin might play a role in neovascularisation, thereby promoting tumor growth. Glycodelin is a biomarker of aggressive malignant pleural mesothelioma and a prognostic biomarker of metastatic non-small cell lung cancer at late stages. Glycodelin hyperexpression is associated with brain metastasis in lung adenocarcinoma, and its determination can be used as an additional prognostic factor.

Conclusion. The review refects basic scientifc data and results of clinical trials, as well as identifes future prospects that allow the development of new methods for cancer detection and treatment. It should be noted that glycodelin plays an important role in tumor development, progression, angiogenesis, and the formation of distant metastases, and therefore can serve as a useful diagnostic and prognostic marker. Further studies of the functional properties of glycodelin are needed to develop promising strategies in cancer therapy.
Efficacy of preoperative therapy in patients with high and low risk of distant metastasis in non-small cell lung cancer
Authors: Pankova O. V. , Tashireva L. A. , Rodionov E. O. , Мiller S. V. , Gerashchenko T. S. , Pismenny D. S. , Zavyalova M. E. , Denisov E. V. , Perelmuter V. M.
Published: January 2023

Background. To select the optimal treatment for non-small cell lung cancer (NSCLC), it is important to predict the risk of distant metastasis and the effectiveness of therapy. The effect of neoadjuvant chemotherapy (NAC) on distant metastasis remains poorly understood. In this study we evaluated the feasibility of predicting the risk of distant metastasis and effectiveness of various treatment options for pre- and intraoperative therapy in NSCLC patients with high and low risk of distant metastasis, divided based on the assessment of morphological changes in the epithelium of small bronchi located near the primary tumor.

Material and Methods. The study included 171 patients with NSCLC (T1-4N0-3M0). Various premalignant lesions: isolated basal cell hyperplasia (BCH+SM-D-), basal cell hyperplasia with squamous cell metaplasia (BCH+SM+D-) and squamous cell metaplasia with dysplasia (BCH-SM+D+) were identified in the bronchial epithelium of small bronchi taken at a distance of 3–5 cm from the tumor. Preliminary studies have shown that the detection of BCH+SM-D- or BCH-SM+D-in small bronchi are the markers of high risk of NSCLC distant metastasis, and the detection of BCH+SM+D- and BCH-SM-D- are the markers of low risk of NSCLC distant metastasis. 52.6 % of patients (90/171) received 2–3 courses of neoadjuvant chemotherapy (NAC), 41.1 % (37/90) of patients underwent intraoperative radiation therapy (IORT) at a single dose of 10–15 Gy and 47.4 % (81/171) of patients received platinum-based adjuvant chemotherapy (AC).

Results. Both treatment options (NAC+IORT+ and NAC+IORT–) effectively reduced the incidence of distant metastases in the high-risk group patients during the first 2 years of follow-up compared with the high-risk group patients who did not received therapy. In the low-risk group patients, distant metastases rarely occurred, regardless of the treatment option. Adjuvant chemotherapy was found to have no influence on the frequency of distant metastases. Metastasis-free and overall survival rates were better in the low-risk group patients or in patients who received the NAC+IORT+ regimen.

Conclusion. Combination of NAC and IORT resulted in the increase in metastasis-free and overall survival rates.
Genetic features of cancer of unknown primary
Authors: Schegoleva A. A. , Tretyakova M. S. , Vorobyov R. S. , Ananina O. A. , Bokova U. A. , Denisov E. V.
Published: January 2023

Background. Cancer of unknown primary (CUP) is a metastatic lesion with diffcult identifcation of the primary tumor site using standard diagnostic approaches. Although the incidence of CUP is not high, this type of cancer often shows a high aggressiveness and therapy resistance and results in poor patient survival. The mechanisms of CUP origin are not clear, and further studies are needed.

This study aims to analyze the mutational landscape of CUP and identify specifc genetic alterations.

Material and Methods. Whole exome sequencing was used to analyze the mutational landscape of CUP. Results. CUP had single nucleotide variants (SNVs) in the EPHA8 (ephrin receptor) gene. CUP also harbored copy number variations (CNAs) in the ID2, FOXD4, ZMYND11, ZNF596, KIDINS220, LRRN1, GEMIN4, CEP72, TPPP, and MXRA5 genes. According to functional enrichment analysis, these genes are involved in the regulation of transcription, biogenesis of microRNA, cellular cytoskeleton, adhesion, extracellular matrix remodeling, proliferation, apoptosis, and epithelial-mesenchymal transition.

Conclusion. Cancer of unknown primary harbors mutations in the genes that regulate different biological processes particularly cell motility.
Myeloid-derived suppressor cells in multiple myeloma patients at the immune recovery and after high-dose chemotherapy and hematopoietic stem cell transplantation
Authors: Tyrinova T. V. , Batorov E. V. , Aristova T. A. , Ushakova G. Yu. , Sizikova S. A. , Denisova V. V. , Ostanin A. A. , Chernykh E. R.
Published: January 2023

Introduction. Myeloid-derived suppressor cells (MDSCs) play an important role in restriction of the immune response and are associated with a poor prognosis in cancer. Mobilization of hematopoietic stem cells (HSCs) before high-dose chemotherapy (HCT) with autologous HSC transplantation (auto-HSCT) is accompanied by a signifcant increase in MDSC counts in peripheral blood and apheresis product of multiple myeloma (MM) patients. However, quantitative changes of these cells at the post-transplant and their role at the immune recovery remain unexplored.

The study was aimed to analyze the dynamics of circulating MDSC counts and the expression of suppressor molecule arginase-1 in patients with MM in the frst 12 months after HCT and auto-HSCT and evaluate association between MDSCs and transplantation outcomes.

Material and Methods. The study included 44 MM patients who underwent HCT and auto-HSCT. The relative number of granulocytic MDSCs (G-MDSCs), monocytic MDSCs (M-MDSCs), and early-stage MDSCs (E-MDSCs), as well as the expression of arginase-1 in each of MDSC subsets was evaluated by fow cytometry in patient peripheral blood samples.

Results. At the engraftment (day +12 – +16, leukocytes >1×109 /l), M-MDSC relative count was increased (pU=0.038), as well as the relative (pU=0.003) and absolute (pU˂0.0001) counts of G-MDSCs, decreasing after 6 months down to pre-transplant values (рU=0.007, рU=0.024 and рU=0.02, respectively) and remaining at the same level at the 12-month follow-up period. The absolute count of E-MDSCs by the time of the engraftment decreased transiently (pU=0.004 vs before HCT), gradually recovering by 12-month follow-up (pU=0.032 vs day +12 – +16). The remission within 12 months in the group with G-MDSCs˂0.17 % at the engraftment was observed in 67 ± 11 % of patients, with G-MDSCs >0.17 % – in 94 ± 6 % of patients (p=0.049). During the 12-month post-transplant, the number of M-MDSCs expressing arginase-1 has been increasing, with a tendency to lower values at the engraftment in patients with early MM relapse (pU=0.09).

Conclusion. The association of early MM relapse after auto-HSCT with the lower count of G-MDSCs and the lower count of arginase-1+ M-MDSCs at the engraftment suggests that MDSCs is involved in the restriction of homeostatic proliferation as a factor for more effective immune recovery.
Morphological heterogeneity of intratumoral macrophages in prostate tumors
Authors: Danilko K. V. , Enikeeva K. I. , Kabirov I. R. , Maksimova S. Y. , Vishnyakov D. S. , Kzhyshkowska J. G. , Pavlov V. N.
Published: January 2023

Background. Prostate cancer (PCa) is the most common human cancer worldwide. In the progression of prostate cancer, the total number of macrophages in the tumor tissue is associated with poor prognosis and increased risk of metastasis. However, the heterogeneity of intratumoral macrophages at various stages of PCa development, and the role of tumor-associated macrophages (TAMs) have been insuffciently investigated.

The aim of the study was to analyze the morphological features, size and number of TAMs in PCa tissue samples, and to reveal their correlation with clinical data of patients.

Material and Methods. Immunohistochemical analysis of 36 paraffn blocks of patients with PCa (pT2a–3bN0–1M0) was performed using antibodies to the scavenger receptor CD68.

Results. Foamy CD68+ macrophages were found in the tumor tissue. The indicator “number of macrophages per total number of felds of view with macrophages” was the lowest in patients with a Gleason score of 6 (5.8) (11.0 – in patients with a Gleason score ≥ 8). Macrophages formed larger clusters in patients with severe PCa. Small but not large macrophages were signifcantly more common in patients with lymph node metastases (48 vs 24 in the N0 group; p=0.14). The number of small macrophages (smaller than 100 µm2) increased in a series of patients with Gleason scores of 6, 7 and ≥ 8 (24, 47.5, 72, respectively, p=0.052).

Conclusion. As the tumor process progressed and the risk of biochemical recurrence increased, there was a trend towards an increase in the total area of large, foamy TAMs, presumably rich in lipids, as well as wider distribution of small macrophages with a tendency to form clusters. We hypothesize that foamy macrophages are involved in the further recruitment of small TAMs, subsequently leading to metastasis and tumor progression.
Yöresel Yemeklerin Tanıtılmasında Uluslararası Spor Organizasyonlarının Yeri
Authors: IŞILDAR Pınar
Published: January 2023

Günümüzde yöresel yemekler; spor, kültür, eğlence, iş gibi farklı nedenlerle seyahat edenler için ayrı bir çekicilik unsuru haline gelmiştir. Yöresel yemek imajının tatil amaçlı seyahate çıkacak kişilerin destinasyon tercihi üzerinde önemli bir etkisi olduğu ve gastronomi turizmini canlandırdığı bilinmektedir. Uluslararası spor organizasyonları ise farklı kültürleri bir araya getirmesi ve geniş katılımlı olması ile ülkenin ve bölgenin tanıtılmasında bir fırsat olarak görülmeli ve değerlendirilmelidir. Bu çalışma, yöresel yemekleri uluslararası düzeyde geniş kitlelere tanıtmak için bir fırsat olabilecek uluslararası spor organizasyonlarını incelemeyi amaçlamaktadır. Araştırmada Muğla’nın Bodrum ilçesinde 61 ülkeden 276 sporcunun katılımıyla gerçekleşen ve uluslararası bir spor organizasyonu olan 2022 ARKAS Optimist Dünya Şampiyonası örnek olay incelemesi gerçekleştirilmiştir. Şampiyona süresince yiyecek-içecek faaliyetleri incelenmiş ve federasyon yöneticileri, organizatörler, sponsorlar, sporcular, sporcu aileleri, antrenörler ve basın olmak üzere toplam 53 katılımcı ile görüşmeler gerçekleştirilmiştir. Bulgular, uluslararası spor organizasyonlarının yöresel yemeklerin tanıtılmasında önemli olduğunu ve değerlendirildiğinde önemli sonuçlara ulaşılabileceğine işaret etmektedir. Çalışmanın sonunda, uluslararası spor organizasyonlarında uygulanabilecek ve organizasyon komite üyelerine yol gösterebilecek organizasyonel bir model önerisi sunulmuştur.
Sokak Satıcıları Açısından Safranbolu daki Sokak Lezzetlerinin Değerlendirilmesi
Authors: USLU Ayşe Nur , AYYILDIZ Sibel , YUMUK Yurdanur
Published: January 2023

Sokak lezzetleri evde veya sokakta fazla hazırlık gerektirmeden hazırlanan, uygun fiyatlarla beslenme ihtiyacının karşılanmasına olanak sunan, günün herhangi bir saatinde ulaşılabilen ve çoğunlukla açık hava alanlarında satıcılar tarafından hareketli arabalarda ve tezgâhlarda pazarlanan yiyeceklerdir. İsmini dünyanın en pahalı bitkileri arasında yer alan safrandan alan Safranbolu da sokak lezzetleri ile ön plana çıkan şehirlerden biridir. Safranlı lokum, safran çayı, safranlı kahve, bağlar gazozu ve kiren şerbeti gibi sokak lezzetleri Safranbolu’nun tanıtımında kullanılmakta ve yörede turizmden elde edilen geliri artırmaktadır. Safranbolu’ya ait sokak lezzetlerinin sokak satıcılarının bakış açılarıyla değerlendirildiği bu çalışmada temel amaç; söz konusu sokak lezzetlerinin yöresel mutfak kültürünün devamlılığının sağlanmasındaki rolünü ve yöredeki gastronomi turizmine yönelik katkılarını ortaya koymaktır. Nitel araştırma yöntemi ve olgu bilim (fenomenoloji) desenine bağlı kalınarak gerçekleştirilen araştırmanın örneklemini Safranbolu Kıranköy ve Eski Çarşı bölgelerinde sabit veya mobil şekilde çalışan 26 sokak satıcısı oluşturmaktadır. Literatürden yararlanılarak hazırlanan yarı yapılandırılmış görüşme formu ile elde edilen verilerin analizinde içerik ve betimsel analiz kullanılmıştır. Çalışmada Batı Karadeniz Bölgesi’nde bulunan önemli kültür turizmi rotalarından biri olan Safranbolu’ya ait sokak lezzetlerinin yöresel mutfak kültürünün tanıtımına aracılık ettiği ve yörenin gastronomi turizmine katkı sağladığı sonucuna ulaşılmıştır.
Restoran Tercihinde Sosyal Görünürlüğün Etkisi
Authors: ÇAKICI Salih , CANKÜL Duran
Published: January 2023

Bu araştırmada öğrencilerin restoran seçimini etkileyen kriterler değerlendirilerek, restoran seçimi üzerinde sosyal görünürlüğün etkisi ortaya konulması amaçlamıştır. Bu amaç doğrultusunda araştırmanın evrenini Türkiye’de gastronomi ve mutfak sanatları alanında lisans eğitimi olan öğrenciler oluşturmaktadır. Araştırmada nicel araştırma yöntemlerinden anket tekniği kullanılarak 388 öğrenciden veriler toplanmıştır. Elde edilen verilere regresyon, T-testi ve Tek yönlü varyans analizi uygulanarak istatistiksel analizler gerçekleştirilmiştir. Sonuç olarak sosyal görünürlüğün restoran seçimi üzerinde olumlu bir etkiye sahip olduğu sonucuna ulaşılmıştır. Katılımcıların restoran seçiminde kullanmış oldukları sosyal medya araçları ise en çok Instagram, Google, Youtube ve Twitter’dır. Diğer taraftan iletişim kurma, gündemi takip etme, bilgi elde etme ve paylaşım yapmak amacıyla sosyal medyayı kullandığı sonucu ortaya koyulmuştur. Ayrıca katılımcıların restoran seçiminde dikkat ettiği etkenler; temizlik, atmosfer, çalışanların nazik olması, servis standardı, ödeme kolaylığı, çalışanların davranışları, yiyecek lezzeti, siparişin doğruluğu, çalışanların yardım severliği, yiyeceklerin sunumu, yiyeceklerin tazeliği ve oturma ortamının ergonomik olması şeklinde belirlenmiştir.
Lezzetin Nostaljisi: Yiyecek ve Bellek İlişkisi Üzerine
Authors: ÖZGÜNEŞ Reşad Emre , BOZOK Düriye
Published: January 2023

Lezzet-yiyecek-bellek arasındaki mevcut ilişki salt kişisel değil toplumsal yönden de araştırmaya değer bir konudur. Bu çalışmada; lezzet algısı, bu algının kaydedildiği bellek çeşitleri ve gastronostalji kavramı farklı bilim dallarına ait yaklaşımlar sentezlenerek incelenmekte, gastronomi literatürüne farklı bir perspektiften bakılarak katkı sağlanması hedeflenmektedir. Lezzet, yiyecek, bellek ilişkisinin nostalji ve gastronomi bağlamında incelendiği bu çalışmada; geçmişe dair hafızada yer eden lezzetlerin bellekte nasıl kodlandığı, ne şekilde hatırlandığı yerli ve yabancı literatürdeki bilgiler ışığında tartışılmaktadır. Literatürdeki çalışmalara ilaveten, konunun özellikle nörolojik bağlamda daha iyi anlaşılabilmesi açısından, nöroloji alanında, konuyla ilgili çok sayıda çalışması bulunan bazı akademisyenlerin fikirlerine başvurulmuş ve kişisel görüşlerine metin içinde yer verilmiştir. Elde edilen sonuçlar, bireye ait kişisel yemek hatıralarının episodik bellekte kodlandığını göstermektedir. Dolayısıyla gastronostalji kavramını uyandıran/hatırlatan bellek çeşidi episodik bellek olmaktadır.
Hizmet Pazarlaması Bakış Açısıyla Tarımsal Turizm İşletmelerinde Üretim Planlaması ve Yönetimi Faaliyetlerine Yönelik Bir Analiz
Authors: AYDIN Ahmet
Published: January 2023

Hizmet sektöründe faaliyet gösteren tarımsal turizm işletmeleri, son yıllarda ilgi çeken, farklı ve içerik olarak zengin ürünler/hizmetler sunması bakımından turistlerin ilgisini çekmektedir. Özellikle doğayla iç içe, huzurlu ve sessiz bir ortamda, farklı aktivitelerle rahatlanması, farklı hobilerin kazanılmasında fırsatlar elde edilebilmesi, üretilecek ürünlerle organik ve sağlıklı gıda tüketiminin mümkün olabilmesi, farklı kültürler hakkında bilgi ve deneyim sahibi olunabilmesi vb. olanakların/hizmetlerin sunulması bakımından tarımsal turizm işletmeleri daha fazla öne çıkabilmektedir. Özellikleri ve sunulan hizmetler nedeniyle tarımsal turizm işletmelerinin sektördeki payı ve önemi, diğer ülkelerde olduğu gibi Türkiye ekonomisinde de artmaktadır. Çalışmada; üretim planlama ve yönetimi ile ilgili yürütülen uygulamalarla ilgili olarak uygunluk, uygulanabilirlik, üretimde verimlilik ve müşteri/tüketici memnuniyetinin sağlanmasına yönelik analizlere ve önerilere yer verilmiştir. Sonuç olarak, tarımsal turizm işletmelerinin detaylı, stratejik planlamalar ve yönetim süreçleri ile kapasiteleri doğrultusunda ürün/hizmet üreterek faaliyet gösterebilmelerine yönelik analizler ve çıkarımlar geliştirilmiştir. Ayrıca, hizmet pazarlaması stratejileri doğrultusunda, tarımsal turizm işletmelerinin üretim planlama/yönetimi faaliyetlerini başarılı biçimde yürütebilmeleri, hedef kitlelerinde memnuniyet oluşturabilmeleri ve daha fazla müşteri kazanabilmelerine yönelik öneriler sunulmuştur.
Yerel Halkın Yöresel Yemeklere Yönelik Farkındalık Düzeyleri ve Deneyim Durumları: Adıyaman Örneği
Authors: YEŞİLYURT Hülya
Published: January 2023

Bu araştırmanın amacı, Adıyaman ilinde yerel halkın yöresel köfte yemeklerine yönelik farkındalık düzeylerinin ve deneyim durumlarının incelenmesidir. Bu amaç doğrultusunda anket yoluyla yerel halktan oluşan 410 kişiden veri toplanmıştır. Araştırmadan elde edilen bulgulara göre, yerel halkın bilmedikleri ve tatmak istedikleri yemekler arasında ör köfte, şaplak, kadı, tiritli taplama, basala ve basma köfte ilk sıralarda yer almaktadır. Keklikli çiğ köfte, çullu köfte, bulgur kıyması, kel köfte ve yapıştırmalı köfte de ön plana çıkan yemekler arasındadır. Katılımcıların ismen bildiği ancak daha önce tatmadığı ve tatmak istedikleri yemekler arasında ise tiritli taplama, keklikli çiğ köfte, basala, şaplak ve kadı ilk sıralardadır. Elde edilen bulgular doğrultusunda yöresel gastronominin gelişimi ve tanıtımı bağlamında öneriler sunulmuştur.
Rekabet Eden Değerler Yaklaşımına Göre Yönetsel Liderlik Rolleri: Konaklama İşletmelerinde Bir Geçerlilik ve Güvenirlik Çalışması
Authors: KULA Mehmet Emirhan
Published: January 2023

Bu çalışmada Quinn ve arkadaşları (2011) tarafından geliştirilen ve bireysel olarak yönetsel liderlik becerilerini puanlama usulünde hesaplayan Rekabet Eden Değerler Yetkinlik Anketinin kültürel farklılar bağlamında Türkçeye çevrilerek bir ölçek olarak ulusal alan yazına kazandırılması amaçlanmaktadır. Rastlantısal örneklem yönteminin tercih edildiği çalışmada veri toplama amacıyla TÜRSAB’a kayıtlı dört ve beş yıldızlı 63 kış otelinden dörder (iki orta, iki üst düzey) yönetici olmak üzere 252 yönetici ankete katılım sağlamıştır. Doğrulayıcı faktör analizi sonuçlarına göre ölçekte kalan 28 maddenin faktör yüklerinin 0,32’den yüksek ve tüm maddelerin t değerlerinin anlamlı olduğu görülmektedir. Boyutların Cronbach Alpha katsayıları iş birliği odaklı yetkinlik 0,60, kontrol odaklı yetkinlik 0,74, rekabet odaklı yetkinlik 0,71 ve yaratıcılık odaklı yetkinlik 0,65 düzeyinde ve tüm maddeler için madde-toplam korelasyonu 0,28 ile 0,60 aralığında olduğu tespit edilmiştir. Geçerlik ve güvenirlik analizi bulgularına göre Rekabet Eden Değerler Yetkinlik Ölçeğinin 28 madde ve 4 boyuttan oluşan yapısı ile güvenilir ve geçerli bir ölçek olduğu tespit edilmiştir.
User Interface Usability of Mamat Adventure
Authors: Suryani Apong , Mansoor Alvanov Z.
Published: January 2023

A game is a form of entertainment determined by a rule and conflict resolution by the player. A good game can display attractive visuals, make the player get engaged, and feel the needed pleasure. Visual is a medium that only concerns the sense of sight while the other senses like the sense of hearing (sound) cannot be included in the visual use Visual in a game is a part of the user interfaces. The user interface is a medium between a system and the user. The Ministry of Education and Culture of the Republic of Indonesia has released various free website-based edugames that can be accessed and played by Indonesia especially elementary school students. Mamat Adventure is one of the edugames provided by the Indonesian Ministry of Education and Culture. This theoretical exploration has begun with a discussion about the visual appearance related to the user interface in the edugame of Mamat Adventure. This analysis uses the Heuristic Evaluation method initiated by Jakob Nielsen and Rolf Molich to measure the effectiveness of the user interface in the game Mamat Adventure
MYNDOS-ASAR ADASI MİMARİ KALINTILARININ IŞIĞINDA OLASI YAPI PROGRAMI
Authors: GÜLSEFA Gonca
Published: January 2023

Karia kentlerinden birisi olan Myndos, günümüzde Muğla ili, Bodrum ilçesi, Gümüşlük beldesi sınırları içerisinde yer almaktadır. Antik kentin hemen karşısında konumlanan Asar / Tavşan Adası, kentin limanını korumak için oldukça önemli bir lokasyonda bulunur. Ada’da yapılan araştırmalar sonucunda ortaya çıkartılan yapı kalıntılarının bir bölümü, Klasik Dönem ve sonrasına tarihlendirilmektedir. Asar Adası’nın girişinde yer alan açıklık ve bazı mimari buluntular girişte bir propylon (?) olduğu fikrini destekler niteliktedir. Ayrıca adanın daha üst teraslarında “U” / “Π” formlu sunak yapısına ait olduğu düşünülen bir stylobat tespit edilmiştir. Bu alanda yapılan kazılar sayesinde Apollon Arkhegetes’e adanmış olduğu anlaşılan bir yazıt adada Apollon’a ait kült alanının varlığına işaret etmektedir. Detaylı çalışmalarımız kapsamında sunak ve propylon yapıları benzer örneklerle karşılaştırılarak olası yapılarla ilgili bazı mimari öneriler sunulmuştur.
ÉTICA DEL CUIDADO Y EDUCACIÓN DEL CARÁCTER: UNA MIRADA DESDE LA MUJER
Authors: Beltramo Carlos
Published: January 2023

La ética del cuidado es la propuesta de Carol Gilligan, tras notar el sesgo de género que contenía la tabla del desarrollo moral, propuesta por Lawrence Kohlberg. Gilligan plantea que, mientras el varón tiende a resolver los dilemas morales de manera racionalista, apelando a la idea de justicia, la mujer utiliza también el apego y la empatía. Entonces, propone agregar, en el juicio moral, todo aquello que la mujer capta mejor para corregir el sesgo del sistema de Kohlberg. Por su parte, Nel Noddings convierte la ética del cuidado en una propuesta pedagógica, en diálogo con el movimiento de la educación del carácter. Su modelo contempla cuatro componentes básicos: modelamiento, diálogo, práctica y confirmación. Noddings indica que superar el sesgo de género implica que el juicio moral no se reduzca a la racionalidad instrumental, pero propone evitar caer en el emotivismo. De allí que su propuesta apele a una correcta educación del corazón, buscando un equilibrio entre corazón y cabeza. En este sentido, ambas pensadoras lanzan un desafío positivo a las corrientes actuales de la educación del carácter, justo en un momento en que este campo educativo está expandiendo sus reflexiones fundamentales, mientras busca reflejar todos los aspectos de lapersona humana.
APRENDIZAJE Y PARTICIPACIÓN SIN BARRERAS, UNA RESPUESTA A LAS NECESIDADES DEL AULA REGULAR
Authors: Gallegos López Tila del Carmen
Published: January 2023

Integración e inclusión son términos que usamos hoy en el ámbito educativo. Más allá de lo planteado en los planes y programas de estudios, y lo que los medios de comunicación nos venden, podemos preguntarnos: ¿en realidad sabemos lo que significa y lo que conlleva? El presente artículo es producto de una investigación en el ámbito educativo de nivel básico primaria, donde los docentes son la fuente principal de información. Ellos emplean la metodología cualitativa, en su más amplio sentido, enfocada a la investigación, que produce datos descriptivos. Esta se describe como el estudio de la gente a partir de lo que dicen y hacen las personas en el escenario sociocultural. Con esta indagación, el objetivo principal es conocer qué tanto se sabe sobre la educación inclusiva y sus necesidades formativas en los educandos, y cuáles son los ajustes razonables que describen en la planeación o en indicadores de evaluación. Asimismo, si los docentes las realizan o no, o simplemente usan los términos, pero no realizan o llevan a cabo las directrices planteadas en su planeación; también, si conocen realmente cuáles son las BAP (Barreras para el Aprendizaje y la Participación) que enfrentan sus alumnos.
Al ser parteaguas de la famosa llamada inclusión educativa, este se describe como el proceso de abordar y responder a la diversidad de necesidades de todos los alumnos, a través de prácticas educativas inclusivas. Sin embargo, a pesar de los avances en ciencia, cambios en los modelos educativos, formas de pensar, y cambios en los planes y programas de estudios, a lo largo de esta investigación nos damos cuenta que muchos docentes siguen con actitudes arcaicas y se niegan a realizar cambios: continúan realizando una carga desproporcionada e inadecuada de actividades, que no son significativas ni garantizan un aprendizaje significativo en el educando.
UNA EDUCACIÓN LIBERAL
Authors: Tiro Chagoyán Ana Paola
Published: January 2023

A lo largo del libro, el doctor Torralba reflexiona sobre los orígenes, implicaciones y características del modelo educativo liberal. En la introducción, aclara que dicho modelo entiende el término «liberal» como lo hace la tradición, que parte desde Aristóteles hasta Newman. Utiliza dicho vocablo como sinónimo de humanismo. En este modelo, el conocimiento no es valorado exclusivamente por su utilidad, sino como un fin en sí mismo. El objetivo pedagógico no se centra únicamente en preparar profesionalmente al estudiante; el propósito es educar a la persona de manera integral y uno de los pilares que más enfatiza el autor es la formación moral. En este contexto, la libertad es entendida como la capacidad para tomar decisiones asertivas que afectan al sujeto mismo y a su entorno.
Desempenho das operadoras de planos de saúde: antes e durante a pandemia
Authors: Marques Tâmara  Ribeiro Rosa , Oliveira Elis Regina de , Santos Geovane Camilo , Neto Brasilino José Ferreira , Ferreira Ronivaldo Alcebíades
Published: January 2023

Objetivo: Analisar o desempenho econômico-financeiro e operacional das Operadoras de Planos de Saúde (OPS), antes (3T2018-4T2019) e durante a pandemia (1T2020-2T2021) à luz da teoria do isomorfismo institucional.
Metodologia: Trata-se de pesquisa descritiva documental, com o uso de técnicas estatísticas de comparação de medianas (Wilcoxon e Kruskal-Wallis) e correlação (Spearman), entre os indicadores de desempenho e socioeconômicos, considerando as cinco Operadoras de Plano de Saúde (OPS) com maior número de beneficiários.
Resultados: Observou-se redução estatisticamente significativa, após início da pandemia, para os indicadores de rentabilidade, de despesas, variação de custo e de resultado financeiro. Por outro lado, ocorreu crescimento de liquidez corrente e aumento de prazos médios de recebimento de contraprestações (PMRC) e de pagamento de eventos (PMPE). A comparação de desempenho indica que na pandemia a rentabilidade e o PMPE deixaram de apresentar diferenças significativas. Quanto à associação entre as variáveis, a taxa de desocupação apresenta maior número de relação com os índices de desempenhos.
Contribuições do estudo: Evidencia o desempenho das cinco maiores OPS, considerando o período de pandemia Sars-Cov-2, tendo em vista que essas empresas podem ser afetadas diretamente pelo aumento potencial da demanda por assistência à saúde de seus beneficiários. Pelo prisma teórico do isomorfismo institucional essas empresas são referências para o setor.
Análise de fatores contingenciais e sistemas de controles gerenciais associados às práticas de gestão sustentáveis
Authors: Fernandes Thayná de Oliveira , Câmara Renata Paes de Barros , Silva Gilson Rodrigues da
Published: January 2023

Objetivo: O objetivo deste estudo foi analisar como os fatores contingenciais e o uso de sistemas de controle gerencial estão associados às práticas de gestão sustentáveis em organizações.
Metodologia: Foi realizado um estudo de campo (survey), por meio de questionários e entrevistas semiestruturadas com gestores ligados aos sistemas de controles gerenciais em duas empresas criativas do setor de telecomunicações. A amostra tem caráter não probabilístico e os dados foram tratados utilizando a técnica de análise de conteúdo de Bardin (2011).
Resultados: Os achados denotam que a tecnologia, cultura organizacional, fornecedores e clientes, são fatores contigenciais associados com a adoção de práticas de gestão sustentáveis pelas organizações do estudo.s resultados da pesquisa indicam que uso de sistema de controle gerencial interativo constitui uma ferramenta essencial para o estabelecimento de comunicação entre os gestores e funcionários em níveis operacionais das organizações, corroborando para implementação de iniciativas de gestão ambiental. O controle diagnóstico tem sido usado no acompanhamento de metas e implementação de práticas de gestão ambientais com impacto positivo no desempenho organizacional por meio de indicadores de redução de custos, rentabilidade, satisfação do cliente e aumento de vendas.
Contribuições do estudo: A pesquisa proporcionou disseminação na literatura de estudos sobre controles gerenciais sob a ótica da Teoria da Contingência, sobretudo, contribuindo para que as organizações criem consciência ambiental aliado a melhoria de seu desempenho com práticas de controle gerencial. Além disso, a pesquisa possui relevância para que as organizações desenvolvam ações no sentido de reorganizar seus processos e atendam às pressões da sociedade pela adoção de práticas sustentáveis, aumentando a competitividade e melhorando o desempenho organizacional.
Estilos de aprendizagem e técnicas de ensino: uma análise sobre seus efeitos no conhecimento adquirido
Authors: Azevedo Cristiane Munhoz de , Quintana Alexandre Costa , Barbosa Marco Aurélio Gomes
Published: January 2023

Objetivo: Averiguar se os estilos de aprendizagem dos alunos impactam no conhecimento adquirido levando em consideração a aplicação de técnicas de ensino em sala de aula, buscando, especificamente, saber se os sujeitos estudados aprendem no decorrer da aplicação da técnica.
Metodologia: Um quase-experimento em uma turma do curso de graduação de uma Universidade Federal, com abordagem quantitativa por meio da Análise de modelos generalizados mistos.
Resultados: Constatou-se que os estilos de aprendizagem não interferem na aprendizagem dos alunos, nas técnicas método de caso e PBL. Porém, na técnica Role-Play foi constatado que os estilos de aprendizagem interferiram na aprendizagem dos alunos. Deve-se observar que a predominância foi do estilo Assimilador, seguido do Convergente e após Acomodador. Os alunos pertencentes ao estilo acomodador possuíram um rendimento melhor se comparado aos outros alunos dos outros estilos.
Contribuições do Estudo: Observou-se que as técnicas de ensino podem contribuir com o conhecimento, e que especialmente, técnicas mais lúdicas como o Role-Play são favoráveis, mas dependem das características de aprendizagem de cada indivíduo. Dessa forma, o presente estudo contribui para o conhecimento no aspecto de indicar que o uso de técnicas de ensino, pode produzir resultados satisfatórios, desde que percebido o estilo de aprendizagem de cada aluno.
Performance of health plan operators: before and during the pandemic
Authors: Marques Tâmara Ribeiro Rosa , Oliveira Elis Regina de , Santos Geovane Camilo dos , Ferreira Neto Brasilino José , Ferreira Ronivaldo Alcebíades
Published: January 2023

Objective: To analyze the economic-financial and operational performance of Health Plan Operators (HPO), before (3Q2018-4Q2019) and during the pandemic (1Q2020-2Q2021) under the theory of institutional isomorphism.

 Method: This is descriptive documentary research that uses statistical techniques to compare medians (Wilcoxon and Kruskal-Wallis) and correlation (Spearman) between performance and socioeconomic indicators, considering the five Health Plan Operators (HPO) with the largest number of beneficiaries.

 Results: A statistically significant reduction was observed, after the beginning of the pandemic, for the indicators of profitability, expenses, cost variation, and financial result. On the other hand, there was a growth in current liquidity and an increase in the mean receipt timeframe of payments (CRPM) and event payment (APTE). The performance comparison shows that in the pandemic, profitability and APTE were no longer significantly different. As for the association between the variables, the unemployment rate shows the highest number of relationships with the performance levels.

 Theoretical/methodological contributions: Highlights the performance of the five largest OPS, considering the Sars-Cov-2 pandemic period, considering that these companies can be directly affected by the potential increase in demand for health care by their beneficiaries. By the theoretical prism of institutional isomorphism, these companies are references for the sector.
The effects of CPC 47 on earnings management in companies listed in B3
Authors: Dias André Lamblet , Anjos Ludmilla Gomes da Silva dos , Costa Thiago de Abreu , Marques José Augusto Veiga da Costa
Published: January 2023

Purpose: The objective of this study is to analyze the effects of adopting CPC 47 on the level of the earnings management of companies listed in the Brazilian capital market.

Methodology: The sample used in this study is composed of 207companies listed in B3 in the observation period 2012-2021 totaling 2070 observations. The approach is quantitative, using multiple linear regression with balanced panel data. Dechow, Hutton, Kim and Sloan (2012) and Kothari, Leone and Wasley (2005) models were used to improve the discretionary accruals and an earnings management model with control and interest variables.

Results: The results did not confirm the hypothesis that the adoption of CPC 47 affected the level of results management in the analyzed period but showed that indebtedness and operating cash flow explain discretionary accruals, regardless of the adoption of the pattern of revenue recognition. This evidence about earnings management increased with the adoption of CPC 47 was contrary to Baldissera, Gomes, Zanchet and Fiirst (2018), however, according to the findings of Grecco (2013), Jewel and Nakao (2014) and Braga (2020) in relation to the effects of accounting standards. The results indicate that companies with higher operating cash flow can generate accounting information with better quality regardless of the effects of the adoption of CPC 47. The period of the coronavirus pandemic did not significantly affect earnings management levels.

Contributions of the Study: As a contribution, the study expands the theoretical knowledge about the effects of CPC 47 on earnings management. Additionally, in a practical way, it collaborates with regulatory organs, auditors, executives, stakeholders, and the financial market in general.
The difficult construction of public accountability before the Brazilian courts of accounts
Authors: Silva Letícia , Nascimento Roberto Sérgio do , França Edson da Silva , Viotto Ricardo
Published: January 2023

Purpose: To analyze whether there is consistent evidence that Brazilian audit courts are using information and communication technologies (CITs) as instruments to improve transparency, accountability and citizen participation of actions related to the control of public finances.

Methodology: A quantitative research was conducted based on secondary data obtained from the electronic government pages of all 32 (thirty-two) Brazilian state and municipal courts of accounts. Cluster analysis was performed to establish the tc's ranking on 3 (three) perspectives examined in the study (accountability, transparency, and citizen participation).

Results: The evidence points to different levels in the dimensions accountability (38.4%), transparency (83.71%) and citizen participation (64.89%). The examination of the attribute accountability, paradoxically, proved to be worrisome due to the destonating behavior of the courts of accounts – including among brazilian regions – given the requirement that they make this attribute with their jurisdictions, but when analyzed, do not promote it in the same intensity.

Contributions of the Study: The results found in this research may support new evaluations in representative samples, incorporate studies on this theme and assist decision makers.
Management practices in retail trade companies in the east region of the city of Porto Alegre (RS)
Authors: Ribeiro George Wellington Ladvig , Bianchi Márcia , Venturini Lauren Dal Ben
Published: January 2023

Purpose: To identify the managerial accounting practices used in retail organizations in the Eastern Region of the city of Porto Alegre (RS). Moreover, study the effects of the Covid-19 pandemic and the importance attributed to financial reports and management instruments and data analysis systems for taking decisions. In a complementary way, the effect of the Covid-19 pandemic and the importance attributed to financial reports and management instruments and data analysis systems for decision making are investigated.

Methodology: Descriptive research with a quantitative approach, it performed a data collection through a questionnaire with the owners/partners, administrators and employees of retail organizations in the region object of the study, totaling a non-probabilistic and accessibility sample of 26 companies. The questionnaire contemplated the profile of the respondents; management data; importance and use of management instruments and financial reports; and open questions to collect additional information.

Results: Companies are on average micro-companies, with centralized decisions, with a few use of managerial instruments and they comprise accounting as a support for the tax area. The least used management tools are the Balanced Scorecard and product life cycle, and some companies do not even use basic operational and financial controls, such as inventories, accounts payable and receivable, and strategic plan. Also, they attach greater importance to managerial instruments than they use them.

Contributions of the Study: Based on the perception of importance of financial reports and management tools, low level of training of managers, a few knowledge and use of management practices, therefore that more complexity of management tools, less importance attributed by managers to them.
The most relevant intangible assets in generating value in creative economy companies
Authors: Valença Paulo Henrique Leite , Lima Adilson Celestino de
Published: January 2023

Objective: This work seeks to identify which variables best explain the generation of value in creative economy companies that have high investment in intangible assets. The study focused on the creative economy sector of Porto Digital in the city of Recife, Pernambuco, Brazil.

Methodology: The methodology used was exploratory research. For the examination of the variables, the multivariate analysis was used with the application of exploratory factor analysis, and for confirmation, the Spearman correlation model. For data collection, a semi-structured questionnaire prepared in Google Forms was sent to the companies in the second half of July 2021. The responses were validated using Cronbach's Alpha, and the suitability for using factor analysis was measured using the KMO and Bartlett tests. All results were found and demonstrated using the IBM SPSS Statistics 26 software.

Results: The variables highlighted by the results were grouped into three groups and presented in an accounting statement model using the Resource-Based Theory definitions. Finally, the CEO of two of the most prominent Creative Economy companies in Pernambuco gave his opinion on these variables. These comments were placed in the financial statement explanatory note format. The results showed that 13 variables were classified into structural, relational, and human capital.

Study contributions: Creative economy companies essentially work using the ability to manage all their intangible resources. This article is the first to provide empirical evidence on the perceptions of managers of creative economy companies in Porto Digital do Recife about the importance and contributions of intangible assets to generate value in their businesses, as well as assess the organizational resilience of these companies in the context of the covid-19 pandemic.