bluuebunny/crossref_metadata_2025 huggingface dataset:
The microvascular venous pool and its ultrastructural associations in mouse molar periodontal ligament — Periodontal Microvasculature & Nerves
Authors: Sims Milton R.
Published: January 2024

This transmission electron microscopic investigation revealed that the periodontal ligament of mouse mandibular molars contained a microvascular bed typified by a predominance of vessels corresponding in luminal diameter with postcapillary-venules. Vessels in the cervical region showed large areas of the endothelium and basement membrane directly exposed to the investing collagen fibre bundles. Cervical venous capillaries had a ratio of luminal diameter to wall thickness averaging 20:1, whereas postcapillary-sized venules approximated 30:1. In the apical third of the ligament the venous vessels became significantly larger and morphologically conformed to ‘apericytic' postcapillary venules, since they appeared to be devoid of pericytes, and comprised endothelial-like tubes with only the basement membrane and occasional veil cells intervening between the endothelium and the enveloping collagen fibre bundles. The ratio of luminal diameter to wall thickness exceeded 60:1 in these apical vessels. This venous capillary pool of the ligament consisted of vessels which differed ultrastructurally from the postcapillary venules described as being typical of other microcirculatory systems.

Nerve endings, indicated by aggregations of mitochondria, were present adjacent to encapsulated myelinated and unmyelinated nerves located alongside cervical venous capillaries and postcapillary-sized vessels. Encapsulated nerves and nerve groups in the apical region corresponded with descriptions of putative periodontal mechanoreceptors in man, but differed in being related to postcapillary-sized vessels and not collecting veins as reported in human ligament. Unmyelinated axons were frequently located within 0.25 microns of the endothelium of venous capillaries and venules. The oxytalan meshwork fibres were associated with all categories of vessels observed including capillaries having luminal diameters less than six microns.

These findings demonstrate that the mouse periodontal ligament has unique, and previously unreported, vascular and neural anatomical features related to its operant role and dynamic behaviour in supporting masticatory loads. Some functional implications of the present findings are discussed.
Recent vs Historical Migrants: A Study on the Canadian Provincial Trade-Migration Nexus
Authors: Aziz Nusrate , Aziz Ahmed
Published: January 2024

We contribute to the literature by exploring the variation in the trade-creating effect of migration networks across historical migrants and recent migrants by applying a micro-founded gravity model of trade. Both the stock of historical migrants and recent migrants variables are constructed by merging Canadian Census data with the migration data available in Statistics Canada. We address the endogeneity issue by applying IV estimators including two-step feasible GMM and PPML with IV and fixed effects by utilizing the imputed annual migration flow, the historical stock, and recent stock of migrants as instrumental variables proposed by Peri and Requena (2010). Taking Canadian geographical features into account, this study also applies carefully measured gravity variables. We control for the time-varying, exporter-year fixed effects, and importer-year fixed effects in a panel estimation. Estimated results show that annual migration, recent provincial stock of migrants, and historical stock of migrants significantly increase Canadian interprovincial trade. This impact is stronger for the stock of historical migrants relative to the stock of recent migrants and annual migration flow. Sub-sample analysis shows that both recent and historical migration consistently increase interprovincial service trade, only but not interprovincial goods trade. A greater combination of English and French-speaking provinces-pair significantly increases interprovincial trade. Regional trade agreements significantly impact the interprovincial trade of Canada. Our estimated results are robust to different estimation methods and alternative measures for the migrants’ stock and flow variables.
Blockchain Based Wireless Sensor Networks for Detecting Nodes
Authors: Alkhfaji Abothar Mohmood
Published: January 2024

The versatility of Wireless Sensor Networks (WSNs) and other unique qualities inspired by real-time collaboration between the sensor nodes make them widely used for a range of applications in monitoring and surveillance. As solutions for malicious node identification involve a single, centralized decision-making process, security in WSNs is becoming more and more important. Errors are difficult to prevent with this paradigm, and repeatability and traceability are problems. Therefore, the detecting ability and integrity of the developed detection method cannot be guaranteed by malicious node identification technology in ordinary WSNs. This article provides insights into this innovative idea as well as a thorough investigation of the use of blockchain technology to WSNs (Blockchain-Based WSN), including a full analysis of a blockchain-based method for identifying rogue nodes. The Blockchain-Based WSN architecture, business-specific applications, and use are all included in this study. The Blockchain-Based WSN architecture model for tracking malicious nodes and the smart contract features of malicious node detection is both included in the explanation of harmful node identification based on Blockchain-Based WSN in this paper. The second part of this study investigates the use of blockchain technology to the management of WSN data, which necessitates online information aggregation and may also require auditing, event logging, and storage for information analysis and offline query processing. The traditional WSN data management approaches are discussed first in this study, followed by the blockchain-based WSN data management choices. The benefaction of blockchain to WSN security management is also included in this survey. Before discussing blockchain-based WSN security management solutions, such as those that provide access control, protect data integrity, ensure anonymity, and prolong the life of WSN nodes, it first looks at the security vulnerabilities of centralized WSN models.
Applications of Machine Learning in Mobile Networking
Authors: Shnain Ammar Hameed
Published: January 2024

Communication networks are constantly increasing in size and complexity. Hence, the traditional rule-based algorithms of these networks will probably not operate at their most effective efficiency. Machine learning (ML) is being used these days to solve tough problems in a variety of industries, including banking, healthcare, and enterprise. Communication network performance can be improved using computational models that can deliver ML algorithms. This paper investigates the use of ML models in communication networks for prediction, intruder detection, route and path allocation, quality of service enhancement, and resource management. A review of the current literature suggests that there is a wealth of potential for researchers to leverage ML to solve challenging network performance problems, especially in the development of software-based networks and 5G.
Gaze Tracking for Hands-Free Human Using Deep Reinforcement Learning Approach
Authors: Ullah Irfan , Ali Abid , Rasool Shahid , Khan Abdul Moiz , Batool Iqra , Javed Manahil , Kalsoom Sarara
Published: January 2024

People with disabilities have new and advanced methods to communicate with the applications for virtual keyboards and other communication tools. In this paper, we utilized a novel deep reinforcement learning-based technique for determining the location of the accessible options for gaze-controlled tree-based menu selection system. A virtual English keyboard has been incorporated into the layout of the new user interface, which also includes improved requests for text modification through the gaze. The two methods used to manage the system are: 1) eye tracking for typing on the virtual keyboard and 2) eye tracking with a device for soft-switch utilizing deep reinforcement learning. Simulation results show that DRL based algorithm outperforms other baseline techniques in terms of total loss and accuracy.
Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy
Authors: Milutinovic Filip , Djordjevic Djordje , Todorovic Djordje , Zaric Dusan , Mihajlovic Filip
Published: January 2024

Prostate cancer is a worldwide health concern with an increasing global incidence. In the Republic of Serbia, it is the third most commonly diagnosed cancer in men. The research aims to determine the influence of PSA value and digital rectal examination on the pathohistological findings of prostate biopsy in men in Central Serbia. The study was designed as a retrospective, cross-sectional analytical study conducted in the period from December 2021 to December 2022 after receiving the confirmation of the Ethics Committee of the University of Applied Sciences Kragujevac. Among 151 respondents aged 49 to 88 who underwent consecutive biopsies during the study period, prostate cancer was detected in 65 (42%). Out of 65 positive biopsies, 33 subjects had a Gleason score of up to 7, while 32 subjects had a Gleason score over 7. Prostate biopsies significantly correlated with PSA levels (p=0.02), while DRE and prostate volume did not show statistical significance on the prostate biopsy result. PSA level testing leads to early detection of prostate disease in the elderly. PSA value was the only clinical variable associated with an increased rate of prostate cancer in men ≥ 70 and older (p=0.02). DRE, PSA, and prostate volume are important parameters associated with an increase in prostate cancer detection rate in men over 70 years of age.
Analysis of Gender-Based Computational Thinking Skills through Project Base Learning (PjBL) Programming Learning Using Fuzzy Method
Authors: Fitri* Zahratul , Safriana Safriana , Meiyanti Rini , Faisal Muhammad , Mamat Rizalman Bin
Published: January 2024

Learning Evaluation is carried out to determine the level of competence possessed by students. Computational Thinking is a learning approach used to improve students' cognitive thinking. Gender-based education is important to be implemented in all educational institutions because men and women have equal rights in obtaining education. Female students are often considered to have more weaknesses in learning technical practices than men, so it is expected to advance the thinking of students, especially gender equality between men and women in thinking in order to be able to compete in the world of work. This study aims to train how to think in solving problems using several techniques in Project Base Learning (PjBL)-based programming learning whose learning evaluation results between male and female students are analyzed using Tsukamoto's Fuzzy Inference method. The results obtained were the development of computational thinking of students totaling 40 people including 20 men and 20 women obtained 4 male students and 3 female students with "very high" scores, 5 male students and 5 female students obtained "High" scores, 8 male students and 12 female students obtained "Medium" scores, 2 male students obtained "Low" grades,  while 1 male student obtained a score of "Very Low". This proves that the implementation of the concept of computational thinking in project-based learning (PjBL) programming learning can increase the level of thinking skills of students in doing learning.
Identification of Students' Misconceptions and Understanding on Thermochemistry Material with Four-Tier Multiple-Choice Tests
Authors: Rosyidah* Kholifatur , Lutfi Achmad , Sanjaya I Gusti Made , Astutik Julia
Published: January 2024

The delivery of chemistry learning lacking meaning and coherence is often associated with the occurrence of misconceptions. These misconceptions when not detected from the start, may persist and affect the understanding of subsequent materials. Therefore, this research aimed to identify misconceptions and understanding of concepts among students, with a focus on factors causing misconceptions about thermochemical materials. A quantitative descriptive approach was used with the four-tier multiple-choice test and questionnaire instruments. The samples comprised students in class XI Science at SMA Kawung 1 Surabaya. The results showed a profile of misconceptions about thermochemical material consisting of system and environment sub-concepts, types of systems, endothermic and exothermic reactions, types of enthalpy, as well as changes in reaction enthalpy. About 15% of students understood the concept, 31% had misconceptions, and 54% did not understand. Factors that caused misconceptions included poor understanding of the material, media used, teachers or methods, and learning resources
Walking the Table: Caring-with landscape
Authors: Gunner Millicent
Published: January 2024

Walking the Table is an experimental project that develops a relationship of care, registering and becoming conscious of subtle changes within an Australian landscape. Drawing on Donna Haraway’s ideas of ‘making-with’1 and Tim Ingold’s concept of ‘thinking through making’2 this visual essay explores ideas of relational care within a rapidly altering landscape and how one may become an attentive participant, moving with a changing landscape as a practice of care. Understanding ‘landscape’ to be a layered entanglement of systems, materials and inhabitants (more-than-human and human) movements and projections that are influenced by the past and present, the role of the photographs and two forms of text is to weave three different layers of conversation that are relational and form an overall narrative.
Photography is used to capture the process of a dialogue emerging between the walker and the landscape, facilitated through the camera and the table when walking the table around the site. Landscape and care is an ever-evolving relationship that requires attentiveness and participation. When a relationship with a landscape is built over a prolonged period of time, revealed are the drastic differences in scales of temporal shifts that landscapes undergo, formulating an ongoing dialogue between the landscape and the inhabitant of that landscape.
Cover image: Shadow 11, Noticing an unusual shadow of a tree branch I looked up. What we humans botanically classify as an Ulmus species had a strange growth on its smaller branches. Unknown to me whether the tree has wing-bark disease or is a cork-winged Elm, after this discovery and unsure whether the Elm was sick or not, each time I passed by, I would check on the tree.
HUBUNGAN TINGKAT STRES DENGAN OLAHRAGA RUTIN MAHASISWA PROGRAM STUDI SARJANA KEDOKTERAN DAN PROFESI DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA
Authors: Ummaiya Fadilla , Tirtayasa Ketut , Griadhi I Putu Adiartha
Published: January 2024

ABSTRACT

The transition from high school to tertiary education requires adaptation, because college is the toughest period during education. Some studies say that Medical Education is the toughest field of study that creates pressure. The pressure that arises is increasing and continues to cause anxiety. The impact of anxiety is stress. One of the efforts to increase stress immunity is by exercising. Exercise is part of one's life and is very useful to balance life, especially for students, by exercising one can reduce the impact of stress physiologically and psychologically. The purpose of this study was to determine the relationship between stress levels and routine exercise among students. This study is an observational analytic study with a cross sectional method using a stress level questionnaire and a sports questionnaire and totaling 80 collage students from the Undergraduate Medicine and Professional Doctor Study Program, Faculty of Medicine, Udayana University, class of 2019 as a respondents. Conducted in April-July 2020 via google form with variable independent of routine exercise and variable dependent stress level and variable confounding of residence, academic achievement, and gender. Based on the results of the Chi-Squere test, it showed that no relationship between stress levels and exercise (p = 0.109). It can be concluded that it has no relationship, so it is necessary to do further research on stress both in relation to routine exercise and other factors.

Keywords: Stress, exercise, medical students
Efektivitas Ekstrak Minyak Atsiri Daun Zodia sebagai Larvasida Aedes aegypti
Authors: Ida Ayu Trisha Kundalini
Published: January 2024

Nyamuk Aedes aegypti adalah vektor dari penyakit Demam Berdarah Dengue (DBD). Berbagai upaya dilakukan untuk mengendalikan penyakit ini melalui pengendalian vektornya salah satunya menggunakan larvasida temephos (abate®). Namun, beberapa penelitian menemukan larva Ae. aegypti sudah mulai resisten terhadap temephos . Oleh karena itu, perlu ditemukan larvasida yang lebih efektif seperti larvasida ekstrak minyak atsiri daun zodia (Evodia suaveolens). Tujuan penelitian ini yaitu untuk mengetahui efektivitas larvasida minyak atsiri daun zodia dalam membunuh larva Ae. aegypti. Minyak atsiri daun zodia dibuat menggunakan 1300 gram daun zodia segar dengan teknik destilasi air. Penelitian ini adalah penelitian eksperimental murni dan dilakukan dengan lima konsentrasi yaitu 0,5 ppm, 1 ppm, 1,5 ppm, 2 ppm, 2,5 ppm, dan satu kontrol. Terdapat 125 larva Ae. aegypti instar III pada tiap kelompok yang dibagi dalam lima kali pengulangan, lalu dihitung jumlah larva yang mati dalam 24 jam. Hasil penelitian ini menemukan minyak atsiri daun zodia pada konsentrasi 1 ppm, 1,5 ppm, 2 ppm, dan 2,5 ppm dapat membunuh 100% larva dalam 24 jam, sedangkan konsentrasi 0,5 ppm hanya mampu membunuh 27,2% larva Ae. aegypti. Larvasida minyak atsiri daun zodia memiliki LC50 pada konsentrasi 0,563 ppm dan LC90 pada konsentrasi 0,724 ppm. Kesimpulan penelitian ini yaitu minyak atsiri daun zodia merupakan larvasida yang efektif untuk membunuh larva Ae. aegypti dan tergolong larvasida sangat aktif karena memiliki LC50 < 50 ppm.

Kata kunci :  Aedes aegypti, larvasida, zodia
HUBUNGAN MELEWATKAN SARAPAN TERHADAP KEJADIAN OVERWEIGHT DAN OBESITAS PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA
Authors: Swari Kadek Gyna Yadnya , Mulyantari Ni Kadek , Yasa I Wayan Putu Sutirta
Published: January 2024

ABSTRAK

Overweight dan obesitas merupakan salah satu masalah kesehatan yang menjadi sorotan dunia bahkan di Indonesia sekalipun. Prevalensi overweight dan obesitas dari tahun ketahun mengalami peningkatan yang cukup signifikan setiap tahunnya. Mahasiswa kedokteran termasuk ke dalam golongan dewasa muda. Mahasiswa kedokteran memiliki komitmen akademik dan non akademik yang dapat berpengaruh terhadap perubahan pola makan, khususnya melewatkan sarapan. Tujuan penelitian ini adalah mengetahui hubungan melewatkan sarapan terhadap kejadian overweight dan obesitas pada mahasiswa fakultas kedokteran universitas udayana.

Penelitian ini dilakukan dengan menggunakan metode observasional analitik dengan pendekatan cross sectional. Jumlas sampel pada penelitian ini berjumlah 42 mahasiswa/i dengan Teknik pengambilan sampel yaitu purposive sampling. Melewatkan sarapan diukur menggunakan kuesioner sedangkan indeks massa tubuh diukur dengan menggunakan alat pengukur timbangan badan dan tinggi badan.

Hasil analisis statistik dengan menggunakan uji chi-square didapatkan nilai signifikan 0,004 < 0,05. Ini berarti terdapat hubungan melewatkan sarapan terhadap kejadian overweight dan obesitas pada Mahasiswa Fakultas Kedokteran Universitas Udayana. Hasil penelitian ini diharapkan mahasiswa lebih memperhatikan sarapan pagi dan penelitian selanjutnya diharakan dapat memasukkan kategori food recall 24 hours.

Kata Kunci: Sarapan, Overweight, Obesitas
GAMBARAN KELELAHAN MATA (ASTHENOPIA) PADA MAHASISWA PROGRAM STUDI SARJANA KEDOKTERAN FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA ANGKATAN 2018 SETELAH BERLAKUNYA KULIAH ONLINE
Authors: REFAYANTI NI MADE ERNITA , Laksmi Utari Ni Made , Ayu Surasmiati Ni Made , Eka Sutyawan I Wayan , Sudarmaja I Made
Published: January 2024

Asthenopia tergolong kejadian yang sering terjadi yang dapat menyebabkan masalah kesehatan mata. Penelitian ini bertujuan untuk mengetahui angka prevalensi dan gambaran kelelahan mata (asthenopia) pada mahasiswa Program Studi Sarjana  Kedokteran Fakultas Kedokteran Universitas Udayana angkatan 2018 setelah berlakunya kuliah online. Metode yang digunakan pada penelitian ini adalah penelitian berjenis deskriptif analitik dengan rancangan cross-sectional, sebanyak 220 sampel. Pengambilan data pada penelitian ini dilakukan dengan cara menyebarkan kuisioner melalui google form. Dari 220 sampel didapatkan prevalensi kejadian asthenopia 98.18% dengan kejadian terbanyak adalah asthenopia ringan. Didapatkan perbedaan bermakna pada distribusi asthenopia berdasarkan jenis kelamin, penggunaan laptop atau komputer (p<0,05) dan tidak ditemukan perbedaan yang bermakna pada distribusi asthenopia berdasarkan penggunaan handphone (p?0,05).  Penggunaan laptop atau komputer yang lebih dari 8 jam paling banyak ditemukan pada kejadian asthenopia sedang dan berat.
HUBUNGAN ANTARA PENGGUNAAN TAS SEKOLAH DENGAN KELUHAN NYERI MUSKULOSKELETAL PADA SISWA SEKOLAH MENENGAH PERTAMA “S” DENPASAR
Authors: Manuela Serrano Christina Zita , Handari Adiputra Luh Made Indah Sri , Griadhi I Putu Adiartha , Muliarta I Made
Published: January 2024

Penggunaan tas sekolah diduga memiliki andil dalam keluhan muskuloskeletal pada pelajar. Hingga kini, belum banyak data mengenai peran keberadaan faktor-faktor terkait penggunaan tas terhadap keluhan nyeri muskuloskeletal pada siswa. Penelitian ini bertujuan mencari ada-tidaknya hubungan antara aspek berat beban, durasi pemakaian, serta jenis tas dengan keluhan nyeri muskuloskeletal pada siswa Sekolah Menengah Pertama “S” Denpasar. Penelitian ini dilakukan secara potong lintang analitik. Bahan penelitian yang digunakan berupa kuesioner nyeri pediatri Varni-Thompson, kuesioner aktivitas fisik Godin Leisure-Time Exercise, serta kuesioner penggunaan tas. Data penelitian kemudian diolah menggunakan software SPSS ver. 24. Jumlah sampel penelitian yang diperoleh adalah 151 orang. Sample dipilih dengan teknik non-random sampling. Analisis hubungan antar variabel dilakukan melalui uji chi-square. Keberadaan variabel perancu meliputi jenis kelamin dan aktivitas fisik turut diamati. Studi menemukan hubungan antara berat tas dengan keluhan nyeri muskuloskeletal (p=0,015). Hubungan juga ditemukan antara jenis tas dengan keluhan nyeri (p = 0,004). Sementara itu, tidak ditemukan hubungan signifikan pada aspek durasi pemakaian dengan keluhan nyeri responden (p = 0,171). Studi tidak menemukan hubungan antara jenis kelamin dengan keluhan nyeri muskuloskeletal (p=0,580), namun tampak hubungan antara aktivitas fisik dengan keluhan nyeri muskuloskeletal (p=0,032).

Kata kunci : nyeri musculoskeletal., tas sekolah., hubungan
HUBUNGAN ANTARA HIPERURISEMIA DENGAN HIPERTENSI DI RSUD SANJIWANI GIANYAR TAHUN 2019
Authors: Cahyawati Putu Nita
Published: January 2024

Latar Belakang: Hipertensi masih menjadi penyebab utama penyakit kardiovaskular dan kematian di dunia, termasuk di Indonesia. Berdasarkan pada penelitian sebelumnya ditemukan adanya kontroversi terkait hubungan antara hiperurisemia dan hipertensi. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara hiperurisemia dengan kejadian hipertensi tersebut. Metode: Penelitian ini dilakukan di RSUD Sanjiwani Gianyar dengan desain penelitian observasional analitik cross-sectional. Data diambil dari rekam medis pasien pada periode Januari–Desember 2019. Teknik pengambilan sampel menggunakan purpossive sampling dengan jumlah sampel sebanyak 104. Hasil: Karakteristik sampel pada penelitian ini yaitu mayoritas berusia lebih dari 60 tahun (51%) dan didominasi oleh jenis kelamin laki-laki (57.7%). Kejadian hiperurisemi pada pasien hipertensi adalah 68.3%. Kejadian hiperurisemia lebih banyak terjadi pada pasien hipertensi grade 1 (68.8%) dibandingkan dengan hipertensi grade 2 (67.2%). Hasil analisis menggunakan uji korelasi Spearman. menemukan bahwa nilai p>0.05, r -0.010. Kesimpulan: Hasil yang menunjukan bahwa tidak terdapat hubungan signifikan antara hiperurisemia dan hipertensi di RSUD Sanjiwani Gianyar tahun 2019.

Kata kunci :  Hipertensi, Hiperurisemia, RSUD Sanjiwani Gianyar
KARAKTERISTIK KLINIKOPATOLOGI GASTRITIS KRONIS DENGAN METAPLASIA INTESTINAL DI RSUP SANGLAH DENPASAR PERIODE 2016-2020
Authors: Arimbawa I Wayan Gede Bandem , Saputra Herman , Ekawati Ni Putu , Sumadi I Wayan Juli
Published: January 2024

ABSTRAK

 

Gastritis kronis relatif umum terjadi di negara berkembang. Gastritis yang berlangsung lama dapat mengakibatkan terjadinya atrofi dan intestinal metaplasia pada mukosa lambung. Ahli patologi mengemukakan terdapat hubungan antara metaplasia intestinal dengan kanker lambung adenocarcinoma tipe intestinal. Sehingga perlu untuk mengetahui karakteristik klinikopatologi gastirits kronis dengan metaplasia intestinal sebagai prekursor terjadinya kanker lambung. Penelitian ini bertujuan untuk mengetahui karakteristik klinikopatologi pasien gastritis kronis dengan metaplasia intestinal di RSUP Sanglah Denpasar periode 2016-2020. Penelitian ini merupakan penelitian deskriptif dengan metode potong lintang (cross-sectional), menggunakan data sekunder pasien gastritis kronis dengan metaplasia intestinal di RSUP Sanglah Denpasar periode 2016-2020. Data dianalisis menggunakan perangkat lunak SPSS untuk memperoleh karakteristik klinikopatologi pasien meliputi: usia, jenis kelamin, status H. pylori, dan temuan endoskopi. Penelitian ini memperoleh 25 sampel gastritis kronis dengan metaplasia intestinal. Sampel terbanyak pada kelompok usia >60 tahun (52%), berjenis kelamin laki-laki (80%), tanpa infeksi H. pylori (95,5%) dengan 3 sampel tidak memiliki data status H. pylori, dan temuan endoskopi terbanyak berupa gastritis eritematosa (60%). Pasien gastritis kronis dengan metaplasia intestinal di RSUP Sanglah Denpasar periode 2016-2020 memiliki karakteristik klinikopatologi terbanyak usia >60 tahun, laki-laki, Non-H. pylori, dan gastritis eritematosa.

Kata kunci : Gastritis, kronis, intestinal, metaplasia, karakteristik, klinikopatologi.
EFFECTIVENESS OF FRUIT JUICE AS COMPLEMENTARY THERAPY ON BLOOD PRESSURE OF HYPERTENSION PATIENTS : A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS
Authors: Mahendra Bayu , Surudarma I Wayan , Wihandani Desak Made , Ruma I Made Winarsa
Published: January 2024

Hypertension treatment can be helped through complementary therapies, one of which is fruit juices. This study aimed to systematically review the evidence from various study regarding the effect of fruit juices on blood pressure in hypertensive patients and the types of fruit juices that are proven to be effective in reducing hypertension.This study is systematic review. Literature searching was conducted in four electronic databases, namely CINAHL, EMBASE, Pubmed, and Sciencedirect with the phrase fruit juices AND (hypertension OR blood pressure). Studies obtained from searching will be selected based on a screening title and abstract, eligibility criteria, and assesment risk of bias. The results of the study obtained 21 final studies with RCT research designs that passed the screening with complete eligibility criteria. However, the studies with valid results only amounted to 8 studies. These data show that as many as 5 studies prove fruit juices can reduce blood pressure in hypertensive patients and 3 other studies have stated the opposite. Thus, it can be concluded that there is strong evidence that fruit juices has a significant effect on reducing blood pressure in hypertensive patients. Fruit juices that have been shown to be effective are orange juice and queen garnet plum juice
PENGARUH EKSTRAK AQUEOUS CLITORIA TERNATEA TERHADAP KERUSAKAN HISTOLOGI OTAK DAN GANGGUAN MEMORI PADA TIKUS WISTAR TERINDUKSI DIET TINGGI LEMAK
Authors: Parisya Sasmana I Gede Aswin , Ananta Kusuma , I Komang Wira , Dhananjaya I Gede Arya Diva , Triana Devy Anggi Amanda , Wihandani Desak Made
Published: January 2024

Pendahuluan: Diet tinggi lemak dapat menyebabkan berbagai macam kondisi salah satunya adalah obesitas. Ketidakseimbangan profil lipid secara langsung bekontrobusi pada stress oksidatif kronis sehingga  dapat mempengaruhi struktur dan fungsi otak. Manifestasi klinis dari gangguan fungsi otak yaitu penurunan memori. Clitoria ternatea L. mengandung flavonoid dan polifenol yang berperan sebagai antioksidan sehingga dapat mencegah kerusakan organ khususnya otak maupun gangguan memori. Tujuan: mengetahui efek pemberian ekstrak air Clitoria ternatea L. terhadap gambaran histologis otak dan gangguan memori tikus dengan induksi diet tinggi lemak. Metode:  Jenis penelitian ini adalah true experimental post-test only menggunakan 25 ekor tikus yang dibagi menjadi lima kelompok yaitu diet normal (ND), diet tinggi lemak (HFD), dan kelompok perlakuan (HFD+CTE250; HFD+CTE500; HFD+CTE750). Ekstrak Clitoria ternatea L. diperoleh dengan metode ekstrak air. Berat badan pasca perawatan, profil lipid (kolesterol, trigliserida, HDL-C, dan LDL), fungsi memori (uji labirin Y), dan gambaran histologis otak diukur dan dianalisis. Hasil: Hasil penelitian ini menunjukkan penurunan sel hipokampus yang signifikan pada kelompok dengan HFD dibandingkan dengan kelompok HFD+CT750 (MD: -82.33; 95% CI (-128.87 hingga -35.79); p=0,03). Kondisi ini juga diperparah dengan kejadian oklusi pembuluh darah yang dapat menghambat peredaran darah pada otak tikus kelompok HFD. Memori spasial tikus dan jumlah entri pada uji Y-maze menunjukkan terdapat penurunan jumlah entri dan memori spasial yang signifikan pada kelompok HFD+CT250 (MD: 37,70; 95% CI (18,38-57,02); p=0,001). Simpulan: ekstrak air Clitoria ternatea L. secara signifikan mempengaruhi gambaran histologis otak dan gangguan memori tikus dengan induksi diet tinggi lemak.

Kata Kunci: Clitoria ternatea L., Histologis otak, gangguan memori.
Karakteristik Pasien Gangguan Fungsi Tiroid di RSUP Sanglah Tahun 2019
Authors: Wardana Rr. Cattleya Allayka , Saraswati Made Ratna , Dwipayana I Made Pande , Gotera Wira
Published: January 2024

ABSTRAK

 

Gangguan fungsi tiroid merupakan suatu kondisi dimana produksi hormon tiroid menjadi tidak seimbang. Gangguan fungsi tiroid merupakan suatu kelainan endokrin terbesar kedua setelah diabetes. Tercatat kasus bahwa 300 juta orang di dunia mengalami gangguan fungsi tiroid dan 50% diantaranya tidak menyadari kelainan tersebut. Penelitian ini bertujuan untuk mengetahui karakteristik gangguan fungsi tiroid berdasarkan fungsi tiroid, usia, jenis kelamin, dan pola kunjungan pasien di Poli Diabetic Center RSUP Sanglah. Penelitian ini dilakukan dengan metode deskriptif menggunakan studi potong lintang. Sampel ini dipilih dari populasi berdasarkan kriteria inklusi dan eksklusi. Hasil penelitian ini menunjukkan bahwa sebanyak 596 pasien mengalami gangguan fungsi tiroid di RSUP Sanglah tahun 2019 yang terdiri dari 484 (81,2%) pasien dengan hipertiroid dan 112 (18,8%) pasien dengan hipotiroid. Gangguan fungsi tiroid ini didominasi oleh rentang usia 41-50 tahun (29,9%) dengan hipertiroid lebih banyak terjadi pada usia muda yaitu 31-40 tahun (87,6%) dan 21-30 tahun (87,4%), sedangkan hipotiroid banyak terjadi pada kelompok usia tua yaitu 61-70 tahun (27,1%) dan 51-60 tahun (23,5%). Berdasarkan jenis kelamin, pasien gangguan fungsi tiroid perempuan 458 orang (76,8%) lebih banyak dibandingkan laki-laki 132 orang (23,2%) dengan hipertiroid didominasi oleh perempuan sebanyak 366 orang (75,6%) dan hipotiroid 92 orang (82,1%) merupakan perempuan. Pola kunjungan pasien dengan gangguan fungsi tiroid di RSUP Sanglah tahun 2019 didapatkan bahwa kunjungan tertinggi yaitu pada Februari 2019 (142 kunjungan). Perlu dilakukan penelitian analitik lebih lanjut untuk mengetahui hubungan antara variabel karakteristik.

Kata Kunci: Hipertiroid, Hipotiroid, Karakteristik.
Hubungan Aktivitas Fisik Terhadap Kebugaran Jasmani Mahasiswa Laki-Laki Program Studi Sarjana Kedokteran dan Profesi Dokter Fakultas Kedokteran Universitas Udayana Tahun 2019/2020
Authors: Pramartha I Made Dwi Adi , Sucipta Putri Wayan Citra Wulan , Weta I Wayan , Indraguna Pinatih Gde Ngurah
Published: January 2024

Definisi sehat ialah suatu keadaan sehat yang baik, baik fisik, mental maupun sosial dan bukan sekadar tidak adanya penyakit. Tujuan dari WHO ialah tercapainya tingkat kesehatan yang paling tinggi oleh semua orang. Salah satu faktor yang berhubungan dengan kesehatan adalah tingkat kebugaran jasmani.  Kebugaran jasmani menurut Sutarman, adalah aspek fisik dari kebugaran yang menyeluruh (total fitness), yang memberikan kesanggupan kepada seseorang untuk menjalankan hidup yang produktif dan dapat menyesuaikan diri pada tiap-tiap pembebanan fisik (physical stress) yang layak. Kebugaran jasmani dipengaruhi oleh aktifitas fisik yang dilakukan.

            Penelitian ini menggunakan rancangan penelitian menggunakan metode studi analitik dengan pendekatan cross-sectional menggunakan data primer. Responden merupakan Mahasiswa Program Studi Sarjana Kedokteran dan Profesi Dokter Fakultas Kedokteran Universitas Udayana Tahun Ajaran 2019/2020. Sampel diambil dengan convenience sampling, dan terkumpul sebanyak 40 responden yang memenuhi kriteria inklusi dan ekslusi.

            Pada penelitian ini, responden dengan usia 21 tahun sebesar 18 mahasiswa (45%), tingkat aktivitas fisik dalam kategori rendah sampai sedang sebesar 38 mahasiswa (82,5%), tingkat kebugaran jasmani jasmani dalam kategori kurang sampai sedang sebanyak 33 mahasiswa (82,5%). Berdasarkan hasil analisis secara bivariat dari 40 responden, didapatkan p= 0.357, r=0.131. Simpulan dari penelitian ini ialah tidak ditemukan hubungan signifikan antara aktivitas fisik dengan kebugaran jasmani. Hasil penelitian ini dapat digunakan sebagai bahan dasar untuk melakukan penelitian lebih lanjut mengenai hubungan antara akvitas fisik dengan kebugaran jasmani.

Kata kunci: aktivitas fisik, kebugaran jasmani, mahasiswa fakultas kedokteran, harvard step test, PAQ-A
EKSPRESI EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) TINGGI SEBAGAI FAKTOR RISIKO RESPON KEMORADIASI NEGATIF PADA KARSINOMA NASOFARING NON KERATINISASI SUBTIPE TIDAK BERDIFERENSIASI DI RSUP PROF.DR.I.G.N.G. NGOERAH
Authors: Butar Christine Rosalina
Published: January 2024

Kasus karsinoma nasofaring (KNF) semakin meningkat, dengan 20-30 persen pasien mengalami gagal terapi/rekurensi dan/atau metastasis. Overekspresi EGFR mencapai 80% pada biopsi KNF primer dan dianggap sebagai faktor risiko kegagalan terapi. Penelitian ini bertujuan untuk membuktikan bahwa ekspresi EGFR tinggi sebagai faktor risiko respon kemoradiasi negatif pada karsinoma nasofaring non keratinisasi subtipe tidak berdiferensiasi di RSUP Prof. dr. I.G.N.G. Ngoerah. Sampel penelitian ini adalah penderita karsinoma nasofaring non keratinisasi subtipe tidak berdiferensiasi dan telah mendapatkan terapi kemoradiasi lengkap yang bahan biopsinya diperiksa secara histopatologi di Laboratorium Patologi Anatomi RSUP Prof. dr. I.G.N.G. Ngoerah, yang terdiri dari 23 sampel kelompok kasus yaitu dengan respon kemoradiasi negatif dan 23 sampel kelompok kontrol yaitu dengan respon kemoradiasi positif dari tanggal 1 Januari 2017 sampai 31 Desember 2021. Ekspresi EGFR dinilai dengan pewarnaan imunohistokimia. Hasil penelitian ini menunjukkan rerata usia pasien 48,63 tahun, dengan usia termuda 23 tahun dan tertua 71 tahun serta didominasi oleh pria (62,5%). Ekspresi EGFR dan respon kemoradiasi pada KNF dengan analisis chi-square, didapatkan p-value sebesar 0,044 (p<0,05) dan OR=4,286. Simpulan penelitian ini adalah ekspresi EGFR tinggi merupakan faktor risiko respon kemoradiasi negatif pada pasien karsinoma nasofaring non keratinisasi subtipe tidak berdiferensiasi. Pasien karsinoma nasofaring non keratinisasi subtipe tidak berdiferensiasi dengan ekspresi EGFR yang tinggi memiliki risiko 4,3 kali lebih tinggi untuk mendapatkan respon kemoradiasi negatif dibandingkan pasien karsinoma nasofaring non keratinisasi subtipe tidak berdiferensiasi dengan ekspresi EGFR yang rendah.

Kata kunci : EGFR, karsinoma nasofaring, tidak berdiferensiasi, kemoradiasi
The Incident of People with Severe Mental Disorders: A 5 Years Epidemiology at Nusa Penida I Public Health Center
Authors: Kusuma I Made Peri Ardiana
Published: January 2024

Background: Public Health Center (PHC) is responsible for carrying mental health effort through promotive, preventive, curative and rehabilitative approach. Nusa Penida, an archipelago area included in the Klungkung Regency, has problems in providing advanced (specialist) level health services related to mental health because infrastructure and human resources are not yet available. The aim of this study is to determine the prevalence and characteristic of PWSMD in the NP I PHC area so that it can provide data estimates related to mental health services.

Patients and Methods: This study is a retrospective, single-center observational study from 2017 to 2021 with non-probability sampling technique in a consecutive manner. All data was collected and recorded, then processed and displayed in the form of proportion (percentage), sum, mean (standard deviation), and median (minimum-maximum).

Results: During the study period from 2017 to 2021, a total of 105,137 patient visits were obtained, with 456 visits being PWMD (0.43%) and 370 visits being PWSMD (0.35%). The proportion of PWSMD from PWMD was 81.1%. Sixty five patients were obtained from the total visits of PWSMD with male and the 26-45 year age group had the highest number of percentage (56.7% and 29.2%). Batununggul Village, which is the closest working area to the NP I PHC, has the highest number of patient visits

Conclusion: This study showed that the prevalence of PWSMD in the working area of the NP I Public Health Center was quite high with the majority being diagnosed as paranoid schizophrenia.  Most of the patient visits were from Batununggul village.

Keywords: severe mental disorder, public health care, schizophrenia, nusa penida
PENGARUH PEMBERIAN EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI FITOESTROGEN TERHADAP STEATOSIS HEPAR TIKUS MODEL MENOPAUSE
Authors: Hernowo Elliana Freya , Arijana IGK Nyoman , Sugiritama I Wayan , Ratnayanti IGA Dewi
Published: January 2024

Latar belakang: Wanita menopause akan mengalami penurunan hormon estrogen. Hormon estrogen diketahui memiliki sifat hepatoprotektif yang mampu mencegah terjadinya perlemakan pada hepar.  Penurunan kadar estrogen bisa digantikan dengan senyawa fitoestrogen. Kulit buah naga merah (Hylocereus polyrhizus) diketahui memiliki banyak kandungan antosianin yang terbukti memiliki aktivitas sebagai fitoestrogen.

Tujuan: Mengetahui adakah perubahan steatosis hepar tikus model menopause dengan pemberian ekstrak etanol kulit buah Hylocereus Polyrhizus.

Metode: Penelitian ini merupakan penelitian randomized post-test control group design dengan menggunakan tiga kelompok sampel yang sudah melalui prosedur ovariektomi. Ketiga kelompok adalah kelompok P0 sebagai kontrol tanpa intervensi, P1 dengan intervensi ekstrak etanol kulit buah naga merah dosis 60mg/200grBB, dan P2 dengan intervensi ekstrak etanol kulit buah naga merah dosis 90mg/200grBB.

Hasil: Didapatkan rerata jumlah sel steatosis per 100 sel hepar tikus model menopause pada kelompok P0, P1, dan P2 adalah 59,1259 ± 10,0087; 53,0435 ± 14,0674; 41,5001 ± 10,5814. Hasil One Way ANOVA menemukan adanya perbedaan yang bermakna dengan nilai p = 0,013. Hasil uji Post Hoc LSD menemukan perbedaan rerata antara kelompok P2 dengan P0 ditemukan bermakna (p = 0,004) dan P2 dengan P1 juga bermakna (p = 0,047). Sedangkan P0 dan P1 tidak bermakna (p = 0,247).

Simpulan: Ekstrak etanol kulit buah Hylocereus Polyrhizus memiliki pengaruh terhadap steatosis hepar tikus model menopause. Didapatkan steatosis hepar terendah pada kelompok intervensi 90mg/200grBB.

Kata kunci :  Hylocereus polyrhizus, steatosis, menopause, fitoestrogen
Characteristic Of Amblyopia In Strabismus Children In RSUP Prof. Dr. I.G.N.G. Ngoerah in 2021
Authors: Mahesadhana Ardika Putu Abhinaya , Surasmiati Ni Made Ayu , Kusumadjaja Made Agus , Juliari I Gusti Ayu Made
Published: January 2024

Mata merupakan salah satu organ yang digunakan manusia untuk berinteraksi dengan sesama manusia. Apabila terjadi penurunan visual, maka salah satu faktor resiko yang muncul adalah strabismus. Strabismus umum terjadi pada anak-anak dan menjadi salah satu faktor umum penyebab ambliopia. Oleh karena itu penulis ingin mengetahui apa karakteristik ambliopia pada anak strabismus di RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar pada tahun 2021. Desain penelitian ini adalah deskriptif dengan pendekatan cross sectional. Pengumpulan sampel dilakukan dengan total sampling dengan melihat rekam medis di RSUP Prof. Dr. I.G.N.G. Ngoerah periode Januari 2021 sampai dengan Desember 2021. Terdapat 18 pasien yang didiagnosis strabismus dengan adanya penurunan visus. Jumlah laki-laki 11 (61,1%) dan perempuan 7 (38,7). Sebagian besar pasien berada pada rentang usia 6-11 dan 12-17 tahun (n=8, 44,4%). Sebagian besar pasien berdomisili di daerah Badung (n=5, 83,3%). Terdapat 15 pasien (83,3%) tidak dijelaskan mengenai adanya riwayat keluarga dalam lembar rekam medis. Sebagian besar pasien memiliki arah deviasi keluar atau eksotropia (n=10, 55,6%). Sebagai kesimpulan, terdapat 18 kasus strabismus dengan ambliopia. Sebagian besar adalah laki-laki dengan kelompok usia 6-11 dan 12-17 tahun, memiliki arah deviasi eksotropia, berdomisili di Badung, dan tidak dijelaskan adanya riwayat keluarga pada rekam medis
The Relationship of Age, Surgery Type, and Time to Surgery with Post-Operative Outcome of Open Tibial Fracture Grade III at RSUP Sanglah Denpasar in 2018-2020
Authors: Kesumaputri Komang Diah Kurnia , Subawa I Wayan , Dewi Kadek Ayu Candra , Meregawa Putu Feryawan
Published: January 2024

Open tibial fracture is one of the most common lower extremity fractures in the world, especially in Denpasar City. Clinically, open tibial fracture grade III has higher risk of worse outcome, such as infection and bone healing complication than grades I and II, thus it should be evaluated further regarding risk factors affecting that occurrence. This research aims to know the relationship between several risk factors, those are age, surgery type, and time to surgery with postoperative outcomes in open tibial fractures grade III in terms of clinical, radiological, and functional based on Johner-Wruhs criteria. This research used cross-sectional method and used patients with open tibial fracture grade III who underwent surgery at RSUP Sanglah Denpasar in 2018-2020. Based on the data collection, there were 31 patients fulfilled the inclusion and exclusion criteria. The data collected were characteristics and postoperative outcome assessed using Johner-Wruhs criteria which consisted of 4 categories. From Kendall Tau correlation test, there was no significant relationship between age and outcome (p=0,215) and a significant relationship between time to surgery and outcome (p=0,021). Moreover, the results of Fisher’s Exact Test did not find significant relationship between surgery type and outcome (p=0,720). Based on the results, it can be concluded that time to surgery (debridement) has significant effect on postoperative outcome compared to age and surgery type. Time to debridement also has unidirectional relationship with outcome, which means the longer time to debridement, the worse outcome experienced by the patient.

Keywords : open tibial fracture, surgery type, outcome, age, time to surgery
Description of Compliance With Drugs in Schizophrenia Patients in A Mental Hospital Bali Province Bangli Regency
Authors: Anugrah Pradita Sang Kompiang Irpan , Kusuma Wardani Ida Aju , Sri Wahyuni Anak Ayu , Jaya Lesmana Cokorda Bagus
Published: January 2024

Schizophrenia is a psychotic disorder characterized by disturbances that occur in the mind that cause disharmony thought processes, divided soul, erroneous and inappropriate perception attention, and impaired motor activity that shows behavioral changes. Schizophrenia is divided into two groups, namely positive and negative symptoms. Positive symptoms present delusions and hallucinations, while negative symptoms present withdrawn behavior and self-isolation. This study aims to determine the preference for taking medication in patients. This research is qualitative descriptive study. The population is respondents from patients family who responsible to answer questions submitted. Samples taken with purposive sampling technique in inpatient room Nakula and Kunthi Bali Province Mental Hospital with total 10 patients who were the looked for patients in charge. Data collection was carried out by in depth interviews according to inclusion and exclusion criterion, direct interviews with patient’s family members were carried out with a questionnaire guideline. From the results of the study, it’s found that the level of family knowledge was still low about schizophrenia which caused patients not complete take the medication. This is because too many drugs are consumed, the relationship between health professionals and the health system is poor, also relationship between the care giver and the patient is bad, the culture that’s internalized by the family causes differences in perception, and low adherence to medication rules. From the results of the study, it can be said that medication adherence in patients is still low due to the level of family knowledge about schizophrenia.
OVERVIEW OF CHEST RADIOGRAPH AND CLINICAL SYMPTOMS OF PEDIATRIC PULMONARY TUBERCULOSIS PATIENT IN PROF. DR. I.G.N.G NGOERAH HOSPITAL JANUARY 2021 – JUNE 2022
Authors: Angelina Vioreli , Ayusta I Made Dwijaputra , Anandasari Pande Putu Yuli , Patriawan Putu
Published: January 2024

Tuberculosis (TB) is an infectious disease whose incidence is still quite high in Indonesia. The increasing incidence of pediatric pulmonary TB is still happening today. The diagnosis of pediatric pulmonary TB is still a hot topic because the chest radiograph and clinical symptoms are not typical and are often found in other diseases. The aim of the research is to know the overview of chest radiograph and clinical symptoms of pediatric pulmonary TB patients. This research was conducted at Prof. RSUP. Dr. I.G.N.G Ngoerah January 2021 – June 2022 using a cross-sectional descriptive method and medical record data as source with total sample is 30 people. Univariate analysis was performed using the Statistical Package for the Social Science (SPSS) version 26.0 for MacOS. The results of the study are majority of pediatric pulmonary TB patients at RSUP Prof. Dr. I.G.N.G Ngoerah January 2021 – June 2022 is female (60%), age group 11-16 years (50%), abnormal chest radiograph (96.7%), asymptomatic (63.3%), lymphadenopathy of hilar/paratracheal lymph nodes with/without parenchymal consolidation (96.7%), cough symptoms (30%). Children with pulmonary TB at RSUP Prof. Dr. I.G.N.G Ngoerah January 2021 – June 2022 is dominated by female gender, age group 11-16 years, abnormal chest radiograph, asymptomatic, lymphadenopathy of hilar/paratracheal lymph nodes with/without parenchymal consolidation and symptoms of cough.