bluuebunny/crossref_metadata_2025 huggingface dataset:
PROTEÍNAS PE/PPE: POTENCIAIS ALVOS NA PROSPECÇÃO DE NOVOS FÁRMACOS PARA O TRATAMENTO DA TUBERCULOSE – BREVE REVISÃO
Authors: Pinto Edriele Silva , Carneiro Rita Terezinha de Oliveira
Published: December 2020

A tuberculose (TB) é a principal causa de óbito por infecção bacteriana em todo o mundo. O Brasil é um dos países prioritários em seu tratamento, pois registra alta carga da doença. A cura da TB é passível por meio da adesão ao tratamento farmacológico, todavia o uso irracional dos fármacos anti-TB favorece a evolução e seleção de linhagens do Mycobacterium tuberculosis (Mtb) resistentes ao tratamento. A busca por novas terapias contra a doença é urgente. Proteínas PE/PPE são fundamentais na infecção por Mtb, e por isso podem atuar como alvos moleculares dessas novas terapias. Nosso objetivo foi analisar dados disponíveis na literatura sobre as estruturas das proteínas PE/PPE sintetizadas por Mtb e sobre produção de novos fármacos anti-TB. Trata-se de uma revisão integrativa, e a metodologia consistiu em buscas e análise de artigos publicados em bases de dados, no período de 1998 a 2018. Os autores analisados revelam que as proteínas PE/PPE atuam de maneira significativa em diferentes etapas do processo invasivo do Mtb, contudo ainda não há estudos sobre o desenvolvimento de fármacos que atuem sobre tais proteínas. As proteínas PE/PPE se organizam em conjunto de hélices e apresentam alta solubilidade em compostos polares, o que dificulta sua análise. Ferramentas de bioinformática tem mostrado vantagem na elucidação estrutural e funcional das protéinas, e portanto sugerimos o uso dessas ferramentas na prospecção de novos fármacos anti-TB, preferencialmente que atuem sobre as proteínas PE/PPE devido a sua atuação fundamental para o metabolismo do Mtb.
Marashli Ali Pasha, the Muhafiz of Belgrade and the Mutesarrif of Smederevo Sanjak (1815-1821)
Authors: Savic Aleksandar
Published: December 2020

The vali of Rumelia Marashli Ali Pasha was named the muhafiz of Belgrade and
the mutesarrif of Smederevo Sanjak in the year in which the Second Serbian
Uprising (1815) ended. At the beginning of his administration, a dual
Serbian-Ottoman rule was established in the Sanjak of Smederevo, better
known as the Belgrade Pashalik. The establishment of dual rule was the
initial step in the struggle for the autonomy of the Serbian people (1815-
1833). Using unpublished and published historical sources and relevant
literature the paper presents the political role of Marashli Ali Pasha as
the muhafiz of Belgrade and the mutesarrif of Smederevo Sanjak.
International circumstances were also taken into account.
Pipe size sensitivity in pressure relief networks using genetic algorithms
Authors: Alnouri Sabla , Kijevcanin Mirjana , Stijepovic Mirko
Published: December 2020

This paper utilizes a stochastic optimization approach using genetic algorithms, for conducting rigorous pipe size sensitivity assessments onto the design of pressure relief networks. By sampling high performance candidates, only the finest options can survive. The pressure relief network system that was investigated in this work was previously reported in literature. The problem is constrained and involves minimizing a cost objective function that evaluates the overall network performance, in which the best pipe size combination should be selected for each segment within the network. The overall goal of this paper was to seek cost-effective designs for the pressure relief piping system by exploring different ranges of pipe diameters that are available for each segment in the network and comparing how the overall design of the system is affected, when the number of pipe size options to select from is varied.
Temporal change in laser penetration length of titanium and platinum for double-pulse ablation measured by a novel ablation method
Authors: Furukawa Yuki , Inoue Shunsuke , Hashida Masaki
Published: December 2020

To understand the physics of double-pulse femtosecond laser ablation of metals, the authors have proposed and implemented a new ablation method for measuring the temporal change in the laser penetration length (LPL). The measurements were performed for titanium and platinum with femtosecond laser pulses with a central wavelength of 810 nm, a repetition rate of 10 Hz, and a pulse duration of 45 fs. The delay between the seed pulse and the ablation pulse was between 0.3 ps and 1 ns for titanium and between 0.3 ps and 30 ns for platinum. A low-fluence (below the ablation threshold) seed pulse and a high-fluence (above the ablation threshold) ablation pulse were used for the measurement. The seed pulse modifies the optical properties of the target surface, and the ablation pulse creates a crater on the modified surface. The LPL after seed-pulse irradiation was estimated by analyzing how the ablation rate depends on the laser fluences. With a delay of 300 ps, at which the ablation rate is the lowest for both titanium and platinum, the LPL for a titanium target was 40% of that for the target without seed-pulse irradiation, while the LPL for a platinum target was almost the same as that for the target without seed-pulse irradiation. The reduced LPL corresponded to suppressed ablation for titanium and platinum with a delay of 300 ps. The suppression ratio ηsup (ablation rate with seed pulse divided by ablation rate without seed pulse) for titanium (ηsup=0.5) was less than that for platinum (ηsup=0.8). The LPL measured using the proposed ablation method is a key parameter changed by seed-pulse irradiation. For platinum with a delay exceeding 1 ns, a characteristic increase of LPL was also measured.
Information ergonomics in eHealth
Authors: Okkonen Jussi
Published: December 2020

Maintaining performance in digital ubiquitous work environment is increasingly dependent on the quality of physical, cognitive and organizational ergonomics of work. Since digital work environment is the reign of most knowledge workers, there is a need to elaborate the study of work ergonomics by devoting attention to the issue of information ergonomics. In health care digitalisation has affected operation model thoroughly. It has affected how information is recorded, managed and distributed. Novel service models powered by digital channels offer now ways to practice professions as well as there are several outcomes regarding the whole service area. This paper is a summary of four research projects on how digitalisation affects knowledge work and how working is (re)shaped by sociotechnical work environments with reflection to eHealth. The conclusion in the paper underlines the digital transformation shaping the lives of knowledge workers. Discussion on how sociotechnical reshapes both individual and organisations, not to mention extended organisations. As the working practices as well as conventions and norms dictate the daily flow people have developed digital coping strategies. Paper also discusses the future of information ergonomics research in health care as way to find normative result for enhancing work in sociotechnical environment.

technical environment.
Poems by V. Bryusov “Native Language” and G. Tukai “Tugan Tel”
Authors: Shamsutdinova Regina Gennadyevna , Viktorovna Ananyeva Svetlana
Published: December 2020

In literary criticism, structural and semantic correspondences are established between the author and the reader as elements of aesthetic reality. As a result, another text appears before us, different from the original one. With each new reading, a new edition of the text will appear. In this regard, the question of determining the subjective and objective factors of the reception process becomes important. The tasks set determined the need to refer to a comparative analysis of the poems of Russian and Tatar poets, during which the regularities of the functioning of new meanings emerging in interliterary dialogues are considered. Comparative, hermeneutic and receptive methods of analysis were used in solving the set tasks. As a result of the study, the similarities and differences between the works of V. Bryusov and G. Tukai, dedicated to the topic of the native language, were established, and the peculiarities of perception of the additions of foreign literature by bilingual readers were also identified. The results obtained are significant in the study of the role of the reader as a subject of interliterary dialogues.
Features of spanish headlines with lexical component “Covid-19”(On material of newspapers “El País” and “El Mundo”)
Authors: Noskova Anna Ilinichna , Gazizova Liliya Gumarovna , Nefedova Liliya Amiryanovna
Published: December 2020

According to R. Fowler, the media choose the events on the principle of "news value": for example, news is not just a list of current events, but also what they mean for society, what a valuable information it contains (FOWLER, 1991). The article examines the Covid-19 headlines in the Spanish newspapers “El País” and “El Mundo” in terms of their functional load. The results of the study show that the dominant function of Spanish headlines is informative. Communicative tactics of warning, intimidation and attention attraction are verbalized in the headlines of the Spanish press through the lexical means of the language, in particular the use of precedent names, texts, and quotations. The theoretical provisions of the research are accompanied by relevant examples and linguistic commentary of the authors. The research material and theoretical conclusions are also of an applied nature and can be used for the Spanish language courses (KOLABINOVA, PALUTINA, 2014).
On modern methods of resolving a dispute between entrepreneurs
Authors: Valeev Damir Khamitovich , Shpagonov Alexander Nikolaevich , Gizyatov Timur Ravilevich
Published: December 2020

The article discusses modern ways of resolving conflicts in the arbitration process, analyzes such types of conciliation procedures as mediation, judicial conciliation. The need for further implementation and development of these institutions in the arbitration process is noted. Pre-trial methods of dispute resolution are also considered. Special attention is paid to arbitration proceedings and the activities of ombudsmen for the protection of the rights of entrepreneurs as alternative ways of resolving conflicts in a particular area of ​​entrepreneurship.
PENGARUH PENDAPATAN ASLI DAERAH (PAD), DAN DANA TRANSFER TERHADAP PENGALOKASIAN ANGGARAN BELANJA MODAL
Authors: Siagian Ade onny
Published: December 2020

This study aimed to test the effect of Own Source Revenue and Fiscal Balance Transfer on Capital Expenditure Budget Allocation on Provincial Government on D.I Yogyakarta on 2012 to 2018 based on Statistic Indonesian (BPS).This research uses descriptive quantitative approach, which is measure using multiple linear regression based method use SPSS 24.0. The population of this study is the district / city in the D.I Yogyakarta in 2012 to 2018. The sample is determined based on the census method which is taking a sample of the total population that is as many as 35 samples. The data used in this study are secondary data, that colleted on official website www.djpk.kemenkeu.go.id. The analytical methods used are descriptive analysis, analysis of classic assumption and multiple linear regression analysis with level of significance is 5%. Hypothesis testing is using regression partial test (t-Test) and the coefficient of determination test (R²).This result is Own Source Revenue and Fiscal Balance Transfer had a positive significant affect to Capital Expenditure Budget Allocation. This research is conducted 65,9% of factors influencing Capital Expenditure Budget Allocation. Future research may use others independent variable.
CLASSIFICATION OF YANG–MILLS FIELDS ADMITTING INTEGRALS
OF MOTION FOR THE WONG EQUATIONS
Authors: Boldyreva M. N. , Magazev A. A. , Shirokov I. V.
Published: December 2020

In the paper, we investigate the gauge fields that are characterized by the
existence of non-trivial integrals of motion for the Wong equations. For the gauge
group 𝑆𝑈(2), the class of fields admitting only the isospin first integrals is described
in detail. All gauge non-equivalent Yang–Mills fields admitting a linear integral of
motion for the Wong equations are classified in the three-dimensional Euclidean space
ESTIMATES FROM EVOLUTIONARY ALGORITHMS THEORY APPLIED
TO DIRECTED EVOLUTION
Authors: Eremeev A. V. , Spirov A. V.
Published: December 2020

The field of evolutionary computation emerged in the area of computer science due to transfer of ideas from biology and developed independently for several decades, enriched with techniques from probability theory, complexity theory and optimization methods. Our aim is to consider how some recent results form the theory of evolutionary computation may be transferred back into biology. It has been noted that
the non-elitist evolutionary algorithms optimizing Royal Road fitness functions may be considered as models of evolutionary search for the synthetic enhancer sequences “from scratch”. This problem asks for a tight cluster of supposedly unknown motifs
from the initial random (or partially random) set of DNA sequences using SELEX approaches. We apply the upper bounds on the expected hitting time of a target area of genotypic space in order to upper-bound the expected time to finding a sufficiently fit series of motifs in a SELEX procedure. On the other hand, using the theory of evolutionary computation, we propose an upper bound on the expected proportion of the DNA sequences with sufficiently high fitness at a given round of a SELEX procedure. Both approaches are evaluated in computational experiment, using a Royal Road fitness function as a model of the SELEX procedure for regulatory FIS factor
binding site.
Can we preserve physically meaningful “macro” analyticity without requiring physically meaningless “micro” analyticity?
Authors: Kosheleva Olga , Kreinovich Vladik
Published: December 2020

Physicists working on quantum field theory actively used “macro”

analyticity — e.g., that an integral of an analytical function over a large closed loop is 0 — but they agree that “micro” analyticity — the possibility to expand into Taylor series — is not physically meaningful on the micro level. Many physicists prefer physical theories with physically meaningful mathematical foundations. So, a natural question is: can we preserve physically meaningful “macro” analyticity without requiring physically meaningless “micro” analyticity? In the 1970s, an attempt to do it was made by using constructive mathematics, in which only objects generated by algorithms are allowed. This did not work out, but, as we show in this paper, the desired separation between “macro” and “micro” analyticity can be achieved if we limit ourselves to feasible algorithms.
Advice to new instructors: systems approach
Authors: Kosheleva Olga , Kreinovich Vladik
Published: December 2020

A recent paper provided useful system-based approach to new

school teachers. In this paper, we somewhat modify this advice so that it can be applied to new instructors on all levels, including new instructors at the university level.
Langlands, R., Exemplary Ethics in Ancient Rome, Cambridge, Cambridge University Press, 2018, 368 pp., ISBN: 978-1-107-04060-1
Authors: Correa Soledad
Published: December 2020

[Revisión del libro Exemplary Ethics in Ancient Rome de R. Langlands
ANALISIS METODE PRESERVASI SUBKULTUR BERKALA DAN DENGAN AIR STERIL UNTUK JAMUR Aspergillus sp. DAN Candida albicans
Authors: Sally Gabi Vania , Kurniawan Sandy Vitria , Surja Sem Samuel
Published: December 2020

Pendahuluan: Preservasi yang baik dan tepat dapat mempertahankan koleksi kultur dengan baik. Teknik preservasi subkultur berkala merupakan teknik lama yang kurang dapat menjamin sifat-sifat genetik jamur dalam jangka waktu lama. Air steril adalah salah satu metode alternatif dalam berbagai penelitian dalam menjamin sifat-sifat genetik jamur dalam waktu lama dan dapat dilakukan pada konsep laboratorium sederhana. Penelitian ini bertujuan untuk melihat metode preservasi berkala dan dengan air steril.

Metode: Penelitian ini merupakan penelitian deskriptif dengan desain eksperimental laboratorium pada jamur Aspergillus sp. dan Candida albicans.Penelitian ini melihat metode subkultur berkala dan dengan air steril dalam menjaga viabilitas, tingkat kontaminasi, morfologi dan resistensi terhadap antijamur setelah enam bulan.

Hasil: Jamur dapat hidup setelah dipreservasi dengan subkultur berkala tanpa kontaminasi, perubahan morfologi dan resistensi. Aspergillus sp. dan Candida albicans juga hidup setelah dipreservasi dengan air steril selama enam bulan dengan morfologi yang sama dan tanpa kontaminasi. Zona inhibisi Aspergillus sp. mengalami penurunan namun pada Candida albicans tetap sama.

Simpulan: Preservasi jamur dengan subkultur berkala dan dengan air steril dapat diterapkan pada Aspergillus sp. dan Candida albicans.
HUBUNGAN KADAR GULA DARAH DAN TEKANAN DARAH TERHADAP FUNGSI KOGNITIF LANSIA DI KELURAHAN MERUYA, JAKARTA BARAT
Authors: Margaretha Magistra Cylvia , Turana Yuda , Barus Jimmy , Widjaja Nelly Tina
Published: December 2020

Pendahuluan: Penurunan fungsi kognitif lansia merupakan salah satu perubahan yang terjadi dalam tubuh akibat penuaan. Faktor internal dan eksternal dapat memengaruhi terjadinya penurunan fungsi kognitif lansia. Penelitian ini berfokus pada gula darah dan tekanan darah serta karakteristik lansia sebagai faktor penurunan fungsi kognitif lansia.Metode: Penelitian ini menggunakan metode deskriptif analitik dengan desain potong lintang pada 101 responden. Variabel independen penelitian ini adalah kadar gula darah, tekanan darah, dan karakteristik demografi. Variabel dependen adalah fungsi kognitif lansia. Data dianalisis secara univariat dan bivariate menggunakan metode uji kai kuadrat.Hasil: Tekanan darah memiliki hubungan yang signifikan dengan gangguan fungsi kognitif lansia (p<0,05). Faktor lainnya seperti kadar gula darah, usia, jenis kelamin, dan tingkat pendidikan tidak menunjukkan adanya hubungan dengan gangguan fungsi kognitif lansia (p>0,05).Simpulan: Tekanan darah berhubungan dengan fungsi kognitif lansia. Sebaliknya, kadar gula darah tidak memiliki hubungan dengan fungsi kognitif.
AMNIOSENTESIS: TINJAUAN MENYELURUH
Authors: Masrie Marshaly Safira , Baringbing Jonas Nara
Published: December 2020

Pendahuluan: Amniosentesis adalah suatu prosedur invasif pengambilan cairan amnion untuk mendapatkan sel-sel janin dalam rangka pemeriksaan kromosom, salah satu teknik dan prosedur diagnosis prenatal yang diperkenalkan selama 10 tahun terakhir. Hal ini penting diperkenalkan karena besarnya insiden kelainan kromosom pada bayi yaitu 90 kejadian per 10.000 kelahiran.Tujuan: Artikel ini digunakan sebagai bahan pembelajaran untuk meningkatkan wawasan mengenai amniosentesis yang merupakan metode diagnostik prenatal invasif yang paling sering digunakan dengan tingkat keberhasilan yang cukup tinggi serta membantu agar dapat melakukan pencegahan dan deteksi dini penyakit keturunan dan kelainan bawaan pada janin yang belum lahir.Metode: Penulisan artikel ini menggunakan metode tinjauan naratif sebagai bagian dari studi literatureDiskusi: Amniosentesis memiliki tujuan lainnya seperti menilai tingkat pematangan paru janin dan mengetahui apakah terdapat infeksi pada janin. Prosedur amniosentesis biasanya dilakukan pada usia kehamilan 15 – 20 minggu. Jika prosedur amniosentesis dilakukan di bawah usia kehamilan 15 minggu, dapat meningkatkan kejadian keguguran. Analisis fosfolipid cairan amnion dapat menentukan tingkat pematangan paru janin. Cairan amnion juga dapat digunakan untuk analisis biokimia, studi molekuler, dan microarray chromosome analysis (CMA).
KOMORBIDITAS PADA EPISODE REKUREN SINDROM POSNER-SCHLOSSMAN DAN NEUROPATI OPTIK KARENA ETAMBUTOL
Authors: Dewi Amita Angela Shinta , Dernitra Kristian , Foraldy Thendy
Published: December 2020

Pendahuluan: Posner-Schlossman Syndrome (PSS) atau glaucomatocyclitic crisis merupakan kelainan pada mata dengan karakteristik munculnya serangan unilateral yang akut dan rekuren, diikuti dengan peningkatan tekanan intraokular (TIO) dan inflamasi ringan pada segmen mata anterior tanpa adanya faktor pencetus yang jelas. Laporan kasus ini memaparkan mengenai neuropati optik karena ethambutol (EON) bersamaan dengan munculnya episode serangan rekuren PSS. Kombinasi dari kedua komorbid sangat jarang terjadi, namun dapat memengaruhi prognosis dari kedua kondisi.Kasus: Seorang wanita 41 tahun dengan nyeri dan pandangan kabur pada mata kiri dalam 24 jam terakhir. Pada pemeriksaan fisik didapatkan adanya uveitis anterior mata kiri dan peningkatan tekanan intraokular ODS 21,4 / 56,7 mmHg. Pasien didiagnosis sebagai PSS. 5 tahun kemudian pasien menderita EON setelah 5 bulan penggunaan etambutol dalam terapi tuberkulosis. Pemeriksaan koreksi visus terbaik saat itu 20/80 OD, 20/70 OS, dengan skotoma sekosentral yang tidak spesifik. 1 bulan setelah etambutol dihentikan, pasien mengalami episode serangan rekuren PSS dan mulai memengaruhi progresivitas dari penurunan visus kedua mata mencapai 20/400 OD, 20/200 OS. Pasien ditangani dengan injeksi metilprednisolon 500 mg intravena, setelah beberapa dosis pemberian visus mulai membaik (VODS 20/100).Simpulan: Evaluasi secara berkelanjutan oleh dokter spesialis mata dibutuhkan sebelum dan selama pemberian etambutol, yang difokuskan kepada penggalian riwayat penyakit, faktor risiko sebelumnya, danstatus oftalmologi selama pengobatan. Pemeriksaan lengkap untuk mencari etiologi pada PSS penting untuk mengurangi risiko rekurensi. Faktor psikogenik juga perlu dipertimbangkan.
14C Research at the Laboratory for the Analysis of Radiocarbon with AMS (LARA), University of Bern
Authors: Szidat Sönke
Published: December 2020

The Laboratory for the Analysis of Radiocarbon with AMS (LARA) at the University of Bern measures the radioactive carbon isotope 14C with accelerator mass spectrometry (AMS) in different applications. Besides radiocarbon dating of environmental and archaeological samples,
the LARA focuses on source apportionment of air-borne particulate matter (i.e. aerosols) as well as greenhouse gases such as carbon dioxide and methane. This approach allows the identification and quantification of fossil carbon emissions in these air components, which is relevant for
measures of air-quality improvement. The LARA furthermore develops instrumental setups for and at the AMS in order to analyze 14C samples in ?g-amounts with low contamination and high throughput, preferably using online-hyphenated systems.
Targeted Radiotherapeutics from 'Bench-to-Bedside'
Authors: Müller Cristina , Béhé Martin , Geistlich Susanne , Van der Meulen Nicholas P. , Schibli Roger
Published: December 2020

The concept of targeted radionuclide therapy (TRT) is the accurate and efficient delivery of radiation to disseminated cancer lesions while minimizing damage to healthy tissue and organs. Critical aspects for successful development of novel radiopharmaceuticals for TRT are: i) the identification
and characterization of suitable targets expressed on cancer cells; ii) the selection of chemical or biological molecules which exhibit high affinity and selectivity for the cancer cell-associated target; iii) the selection of a radionuclide with decay properties that suit the properties of
the targeting molecule and the clinical purpose. The Center for Radiopharmaceutical Sciences (CRS) at the Paul Scherrer Institute in Switzerland is privileged to be situated close to unique infrastructure for radionuclide production (high energy accelerators and a neutron source) and access
to C/B-type laboratories including preclinical, nuclear imaging equipment and Swissmedic-certified laboratories for the preparation of drug samples for human use. These favorable circumstances allow production of non-standard radionuclides, exploring their biochemical and pharmacological features
and effects for tumor therapy and diagnosis, while investigating and characterizing new targeting structures and optimizing these aspects for translational research on radiopharmaceuticals. In close collaboration with various clinical partners in Switzerland, the most promising candidates
are translated to clinics for 'first-in-human' studies. This article gives an overview of the research activities at CRS in the field of TRT by the presentation of a few selected projects.
Macroscale Superlubricity and Polymorphism of Long-Chain n-Alcohols
Authors: Reddyhoff Tom , Ewen James , Deshpande Pushkar , Frogley Mark , Welch Mark D. , Montgomery Wren
Published: December 2020

Simple n-alcohols, such as 1-dodecanol, show anomalous film-forming and friction behaviour in the elastohydrodynamic lubrication (EHL) contacts inside bearings and gears. Using tribometer, diamond anvil cell (DAC), and differential scanning calorimetry (DSC) experiments, we show that 1-dodecanol undergoes pressure-induced solidification when entrained into EHL contacts. Different solid polymorphs are formed inside the contact depending on the temperature and pressure conditions. Surprisingly, at moderate temperature and pressure, 1-dodecanol forms a polymorph that exhibits robust macroscale superlubricity. The DAC and DSC experiments show that superlubricity is facilitated by the formation of lamellar, hydrogen-bonded structures of hexagonally close-packed molecules, which promote interlayer sliding. This novel superlubricity mechanism is similar to that proposed for the two-dimensional materials commonly employed as solid lubricants, but it enables the practical advantages of liquid lubricants to be maintained. When the pressure is increased, 1-dodecanol undergoes a polymorphic transformation into a phase that gives higher friction. The DAC and DSC experiments indicate that the high-friction polymorph is an orthorhombic crystal. The polymorphic transformation pressure coincides with the onset of dimple formation in the EHL films, suggesting that the anomalous film shapes are caused by the formation of rigid orthorhombic crystals inside the contact. The unusual friction and film-formation behaviour of 1-dodecanol result from bulk effects that are insensitive to the surface chemistry or topology. This is the first demonstration of macroscale superlubricity inside EHL contacts using a non-aqueous lubricant. This discovery creates the possibility of implementing superlubricity in a wide range of machine components, which would result in enormous improvements in efficiency and durability.
One-Step Simultaneous Synthesis of Circularly Polarized Luminescent Multiple Helicenes Using a Chrysene Framework
Authors: Ikai Tomoyuki , Yamakawa Shoya , Suzuki Nozomu , Yashima Eiji
Published: December 2020

A series of multiple helicenes was simultaneously synthesized in one step by intramolecular cyclization of a single chrysene derivative containing two 2-[(4-alkoxyphenyl)ethynyl]phenyl units accompanied by rearrangements of the aryl pendants. The electrophile-induced double cyclization with or without aryl migrations proceeded efficiently under acidic conditions to afford annulative p-extension of the chrysene units and produced quadruple (QH-2), triple (TH-2), and double (DH-2) helicenes containing [4]- and/or [5]helicene frameworks with dynamic and/or static helicene chirality in one step. Three multiple helicenes’ structures were determined by X-ray crystallography and/or density functional theory calculations. The multiple TH-2 and DH-2 helicenes were separated into enantiomers because of the stable one and two [5]helicene moieties, respectively, and showed intense circular dichroism and circularly polarized luminescence. Although QH-2, which comprises four [4]helicene subunits, was not resolved into enantiomers, the TH-2 enantiomers were further separated into a pair of diastereomers at low temperature resulting from their substituted [4]helicene chirality.
Gold-Catalyzed Carboamination of Allenes by Tertiary Amines Proceeding with Benzylic Group Migration
Authors: Milcendeau Pierre , Gandon Vincent , Guinchard Xavier
Published: December 2020

Tertiary amines bearing a benzyl-type group (CH2Ar) undergo Au(I)-catalyzed intramolecular addition to allenes. A formal 1,3-transfer of the CH2Ar group takes place during the cyclization. As demonstrated by both experimental and DFT studies, these unprecedented intramolecular carboaminations involve two consecutive [3,3] rearrangements via a dearomatized intermediate. Because of the poor stability of the enamine products, protocols were developed to convert them in situ to more stable polycyclic chiral compounds.
Estabilidad oxidativa de los aceites de sacha inchi (Plukenetia huayllabambana y Plukenetia volubilis) y su importancia en la industria alimentaria
Authors: Chasquibol Nancy , Iparraguirre Karen , Huamán José , Alarcón Rafael
Published: December 2020

El objetivo de este trabajo es determinar la estabilidad oxidativa de los aceites de sacha inchi (Plukenetia huayllabambana y Plukenetia volubilis) sin microencapsular y microencapsulados con diferentes materiales de pared, empleando el método de Rancimat a 70 °C, 80 °C, 90 °C y 100 °C y la técnica de extrapolación lineal en función de los periodos de inducción se estimaron los tiempos de vida útil a 25 °C. Se realizaron los siguientes análisis físico-químicos: índice de acidez, índice de peróxidos, estabilidad oxidativa y humedad.
Fish sanctuary as a sustainable management tool for recovering fish biodiversity, production and livelihood: A case study on Halti Beel tank sanctuary, Bangladesh
Authors: Siddique Md. Abu Bakar , Hussain Muhammad Afzal , Alam Mohammad Manjurul , Haque Md. Ayenuddin , Flowra Fawzia Adib
Published: December 2020

Fish sanctuary is a common tool for retrieving fisheries diversity in a threatened aquatic ecosystem. The present study highlighted a case study on sustainable management of Halti Beel tank sanctuary, Bangladesh (a part of Chalan Beel) established for the betterment of fisheries and fishermen community. The study was conducted for a period of 6 months from July to December 2017. Both primary and secondary data was used for a comparison before and after effects of Halti Beel tank sanctuary considering three parameters viz., fisheries diversity, production trends and socio-economic condition of fishermen community. During the study period, diversity in both native and exotic fish species (71) were increased where 62 species were native and 9 were exotic under 26 families of 11 orders. This number (71) was observed 97.22% higher than the number of species before declaring Halti Beel tank as fish sanctuary. Recovery rate was observed highest for the order Siluriformes (11) and the lowest for Channiformes (1). Cypriniformes was the most diversified order with 24 species (18 native and 6 exotic species). The observed data showed a dramatic increase in fish production from 8.77 to 37.50 metric ton within four fiscal years whereas the gradual production trend was recorded 10.12, 29.47, 35.10 and 37.50 metric ton, respectively in the year 2013-2014, 2014-2015, 2014-2015 and 2016-2017. The study was also showed a satisfactory improvement in financial and housing assets as socio-economic status of fishermen community involved in the management of Halti Beel tank sanctuary.
Integrated pest management of fall armyworm infestations in maize fields in Nepal: A review
Authors: Khatri Sushil , Pakuwal Prakash , Khanal Saugat
Published: December 2020

Spodoptera frugiperda, commonly known as Fall Armyworm (FAW), is amongst the most terrifying pests of maize in Latin America, which unexpectedly appeared in Nepal in 2019 and spread expeditiously. Estimates of maize crop losses due to this pest are vital in order to compare the effect of these losses with the convenient of controlling FAW and suggest pertinent controlling technology and methods. Nepal is predominantly an agrarian nation thus, maize is grown substantially. However, climatic conditions of Nepal favor the outbreaks of pests such as FAW in many maize grown areas. On the grounds that most of the people of hill and mountainous regions depend on maize for their staple food, pests have appeared to be a great threat to cereal production. It causes   considerable   injuries   to   maize   by   feeding   on   leaf whorls, ears and tassel which often leads to total yield loss.  Yet, agriculture is an economic activity, even among subsistence farmers in Nepal. Seeing high potential losses caused by FAW, different control methods have been proposed. This pest demands meticulous and stepwise plan for its management. This review emphasized on adoption of IPM methods of pests’ control, which is the integration of biological, cultural, physical, chemical, and technological approaches. Meanwhile, early warning systems, though poorly developed in Nepal, can be highlighted for further studies and for further research work.
A review on status, implications and recent trends of forest fire management
Authors: Attri Varun , Dhiman Rajeev , Sarvade S.
Published: December 2020

Forest fire spread out in an area having combustible material in the summer season with high temperature. It burns the area and looks like a misery. Forest fire is one of the factors that severely affects the forest biodiversity. Burning actions in a forest affects not only flora and fauna but also soil properties changed due to the forest fire. In summer season on sloppy topography forest fire originates in tropical forests. While in coniferous forests, forest fire outbreaks during the resin extraction activities. More than 350 million hectares (ha) was estimated to be affected by vegetation fires globally. In India about 55% of forest area is prone to the fire. Fires can be natural or man- made, but manmade fire affects mostly. Several forest types and areas are more susceptible to forest fires because of suitable weather, topography and inflammable material. Forest fires adversely affect the soil, water, flora and fauna and disrupt the ecological functions. The new advances in fire control are remote sensing and GIS where real time information can be gathered about the fire break and immediate follow can be done. The chemicals (as borate, ammonium sulfate and ammonium biphosphate) are used for fire control and various other types of fire retardants are used to keep the fire under control. Forest fire changes the composition of vegetation, extinction of species, development of the various adaptations in unwanted plants. Nutrient cycle and soils are affected. Frequent forest fire events cause global warming. Forest fire needed to be controlled at initial stage and the large fires should not be allowed to occur, the modern techniques of monitoring, detection and control must be used for avoiding the large fires happenings.
DIAGNOSTICS OF HEADLIGHTS FROM NEAR AREA ON PLACE OF BASING
Authors: Besova O. , Karlov V. , Lukashuk O. , Petryshenko I.
Published: December 2020

Methods of microwave diagnostics of a phased array allow reconstructing the amplitude-phase distribution in the antenna and implement on this basis methods for adapting the lattice control to those found in the amplitude-phase distribution to defects. The methods of microwave diagnostics from the near zone described in the well-known literature are realizable only in anechoic chambers or on specially equipped training grounds. To solve the problems of adapting a phased antenna array to a technical state and increasing its operating time under extreme conditions, it is necessary to have methods of integrated microwave diagnostics of a phased antenna array at its location. The aim of the article is to develop a method for microwave diagnostics of a phased array antenna, implemented from the near zone of the antenna at its location, and eliminating the influence of echo signals (ES) on the diagnostic results. The article proposes a method for microwave diagnostics of a phased array antenna from the near field, which allows to exclude the influence on the accuracy of diagnostics of the echo signal present at the measuring site and errors in the positioning of the measuring probe. The proposed method will make it possible to implement microwave diagnostics of the antenna from the near field at its location. The results of microwave diagnostics are supposed to be used to implement various methods of adapting a phased array to a technical condition, significantly increasing its life
ХАРАКТЕРИСТИКИ СИГНАЛІВ МОДУЛЯЦІЇ ЦИКЛІЧНИМ ЗСУВОМ КОДУ З АДАПТАЦІЄЮ ПО ШВИДКОСТІ ПЕРЕДАВАННЯ ІНФОРМАЦІЇ НА ОСНОВІ ДОСКОНАЛИХ ДВІЙКОВИХ МАТРИЦЬ
Authors: Moskalenko А. А. , Sokol G. V. , Korotun T. M. , Uhlianutsa А. H. , Shuhailo А. О.
Published: December 2020

За результатами досліджень встановлено, що важливою характеристикою систем радіозв’язку спеціального призначення є перешкодозахищеність. Перешкодозахищеність включає скритність системи та її перешкодостійкість. Перешкодостійкість, структурна та енергетична скритність системи радіозв’язку спеціального призначення визначаються характеристиками використовуваних сигналів. В роботі представлено результати дослідження характеристик сигналів модуляції циклічним зсувом коду з адаптацією по швидкості передавання інформації на основі досконалих двійкових матриць, а саме структурної та енергетичної скритності. За результатами проведених досліджень встановлено, що використання сигналів модуляції циклічним зсувом коду з адаптацією по швидкості передавання інформації на основі досконалих двійкових матриць замість М-послідовностей дозволить підвищити структурну скритність радіосистем спеціального призначення. Структурна скритність сигналів модуляції циклічним зсувом коду з адаптацією по швидкості передавання інформації на основі досконалих двійкових матриць більша за структурну скритність М-послідовностей, до того ж, при збільшенні довжини кодової послідовності, структурна скритність сигналів модуляції циклічним зсувом коду з адаптацією по швидкості передавання інформації на основі досконалих двійкових матриць зростає стрімкіше. Енергетична скритність сигналів модуляції циклічним зсувом коду з адаптацією по швидкості передавання інформації на основі досконалих двійкових матриць ідентична енергетичній скритності сигналів М-ічної ортогональної модуляції. Напрямком подальших досліджень є дослідження перешкодостійкості сигналів з адаптацією по швидкості передачі інформації на основі досконалих двійкових матриць в умовах багатопроменевого розповсюдження радіохвиль
INNOVATIVE TEACHING AND BEST PRACTICES: UKRAINIAN UNIVERSITIES
Authors: Morze Nataliia , Vasylenko Svitlana
Published: December 2020

The purpose of this study was to identify the most used, popular innovative technologies, best pedagogical practices; comparison with the experience of EU universities and the creation of recommendations that will enable Ukrainian partners in the future to prepare applicants for higher education competitive in the labor market. This study was conducted to implement one of the goals of the project - effective cooperation between the pedagogical sector of higher education in Ukraine and the EU, school teachers and their associations. The Ukrainian participants of the project faced the task: to formulate an understanding of the necessary aspects for creating a profile of student competence in new disciplines, to build profiles of digital competence of teachers and lecturers based on the exchange of knowledge gained from EU partners. As part of the project tasks, an analysis of the level of educational programs and best pedagogical practices, issues of community importance, exchange of pedagogical experience between university teachers and university departments, technological features of university leadership support for teachers' innovation, student involvement in research and project activities, use of technical means by teachers of Ukrainian universities - project partners, current assessment systems and priority areas of educational culture.
Development of an experimental installation for thermoelectric cooling of the chamber
Authors: Naumova Olga Valerevna , Katkov Danila Sergeevich , Spiridonova Elena Vladimirovna
Published: December 2020

The article is devoted to the development of an experimental installation for studying the process of thermoelectric cooling based on the Peltier element when performing laboratory work and conducting scientific research. The developed installation allows not only to obtain low temperatures by applying voltage to series-connected semiconductor elements, but also to test modules with various physical and chemical properties.
Characters in hypno teaching and neuroscience: an overview
Authors: Roswendi Achmad Setya , Khoiri Ahmad , Sunarsi Denok
Published: December 2020

Moral degradation as an indicator of the weak character of students who represent the character of the nation is increasingly concerning, the study aims to identify characters through Hypno teaching and neuroscience studies. Literature research with a systematic review through previous research in the years 2010-2019. The results showed that the contribution of Hypno teaching is very important in realizing student character through the cognitive development of children's brains. Student characters are motivation, self-efficacy, empathy, and sympathy for others. the contribution of the research is great hope for the life of the nation in the future in realizing a golden generation of character.
Resosialisasi di lembaga pemasyarakatan khusus anak
Authors: Haryaningsih Sri , Hariyati Titik
Published: December 2020

A child in conflict with the law is defined as a child who is undergoing a punishment process and is 12-18 years old and is not married. Based on data from the Directorate General of Corrections (Ditjen PAS) of the Ministry of Law and Human Rights in 2019, it was recorded that 56 cases of children had received court decisions. The purpose of this study was to determine the patterns of child growth and development and the factors that influence the development of children in the Penitentiary of West Kalimantan Province. This research is a qualitative research with research subjects are childrens at the Institute for Special Development for Children (LPKA). This research was conducted with structured interviews and observations of child prisoners in LPKA. Data analysis was carried out in the following stages, namely data reduction, data triangulation and data presentation and drawing conclusions/verification. The results found that the development of child prisoners in LPKA was not yet effective. The factors that influence child development are facilities, infrastructure and psychological aspects of the child.
An Overview of Lifelong Learning and Adult Education
Authors: AKMAN Pınar , DEMİROGLARI Burcu , TUNCEL Filiz , KUTLU Mahmut Oğuz
Published: December 2020

Hayat boyu öğrenme ve yetişkin eğitimi ile ilgili literatür incelendiğinde, hayat boyu öğrenme ve yetişkin eğitimi teriminin tanımı, yetişkinlerin neyi nasıl öğrendikleri, yetişkinlerle çalışırken uygun öğretim yöntemlerinin neler
olduğu ve yetişkinler için eğitim etkinliklerinin nasıl tasarlanması ve organize edilmesi gerektiği üzerine odaklanılmıştır. Yetişkin eğitimi terimi, özellikle yetişkinler için tasarlanmış tüm eğitim etkinliklerini belirlemek için
kullanılmaktadır. Hayat boyu öğrenme ve yetişkin eğitimi, kimlik yaratmanın temel bir yoludur ve üretim dinamikleri tarafından yönetilen bir toplumda kullanılabilecek bir lüks değil, her bireye dokunan hayati bir ihtiyaçtır. Literatür
çalışmalarının araştırmacılar için önemi inkâr edilemez. Yapılacak araştırmanın, kim tarafından ne ölçüde çalışıldığını belirlemenin, araştırma sürecini kolaylaştıran en önemli adımlardan biri olduğu düşünülmektedir ve bilgiye
en doğru ve en kısa şekilde nasıl gidileceği konusunda önemli bir yol göstericidir. Bu bilgiler ışığında, araştırmanın amacı hayat boyu öğrenme ve yetişkin eğitimi kavramına genel bir bakış sağlanırken aynı zamanda hayat boyu gelişme,
yetişkin öğrenmesi, androgoji terimi, yetişkin öğrenme teorileri ve temel becerilerin incelenmesidir. Bu amaca ulaşabilmek için bu araştırmada, literatür (kaynak) taraması yöntemi kullanılmıştır. Hayat boyu öğrenme ve yetişkin
eğitimi ile ilgili temeller belirlenmiş ve süreçte yer alan konuların önemli bölümlerinden bahsedilmiştir. Bu bağlamda hayat boyu öğrenme ve yetişkin eğitiminin gelişimleri tartışılmıştır. Bu alandaki eksikliklerin giderilmesi
için üniversitelerin yetişkin eğitimini bir disiplin olarak ele almaları, hayat boyu öğrenme ve yetişkin eğitimi üzerine daha çok araştırma yapmaları önerilmiştir.
Utilização da lei de Lambert-Beer para determinação da concentração de soluções
Authors: Canassa Thalita A , Lamonato Anna Luisa , Ribeiro Allan Victor
Published: December 2020

Neste trabalho abordamos a caracterização de soluções de sulfato de cobre II penta-hidratado (CuSO4.5H2O) utilizando a técnica de espectroscopia no UV-Vis. Empregando a Lei de Beer, foi possível calcular o coeficiente de extinção molar do CuSO4 em solução. Estes parâmetros são úteis para determinações quantitativas de cobre em solução. Os espectros analisados apresentaram uma única banda de absorção centrada em 810nm e transparência na região correspondente à cor azul no espectro eletromagnético. DOI:http://dx.doi.org/10.30609/JETI.2018-2.5930
Aproveitamento de resíduos provenientes do pó de serra no concreto. Influência em propriedades físicas e mecânicas.
Authors: Carvalho Camila
Published: December 2020

O concreto é uma mistura de aglomerantes com agregados miúdo e graúdo, podendo ser produzido com a inclusão de materiais descartados no meio ambiente. A utilização desses materiais diminui a retirada da matéria prima não renovável, no caso desse trabalho o agregado miúdo a ser substituído é a areia. O trabalho tem como objetivo avaliar as alterações nas propriedades físicas e mecânicas do concreto com a substituição do agregado miúdo por resíduo vegetal da madeira, o pó e serra com e sem tratamento. Definindo também a melhor aplicação do resíduo do pó de serra, através dos ensaios de resistência ao impacto, resistência à compressão e absorção de água no concreto. Observou-se que o pó de serra influenciou nas propriedades físicas e mecânicas do concreto, melhorando a resistência ao impacto balístico, à diminuição da absorção da água com o resíduo de pó de serra tratado e alterações nas propriedades físicas como o abatimento do concreto, o concreto com maior teor de pó de serra teve diminuição na resistência a compressão do concreto. DOI: http://dx.doi.org/10.30609/JETI.2018-6011
Protocols for 3D-printing pieces by fused deposition modeling for research purposes: from modeling to post-printing treatment
Authors: Guima Katia-Emiko , Fialho Felipe L. B. , Martins Cauê Alves
Published: December 2020

Additive manufacturing or 3D-printing is a revolutionary technique for prototyping and building objects for final use. Since the first registers at ~1890 the improved technology has boosted the applications of such technique, decreasing its market price. The most affordable 3D-print technique is Fuse Deposition Modeling (FDM), which is based on a layer-by-layer deposition of a fused polymer on a cooled table. Although FDM has been used by industrials, students and researchers, there are few published protocols dealing with small challenges and daily problems. Here we use a basic object to detail pre- and post-printing steps. This technical note offers the reader tools to model, print and treat the 3D-object. We point out basic challenges, such as positioning the objects on the virtual table of the slicing software, that may lead towards undesirable printed pieces. The protocols described here do not cover the uncountable possibilities of 3D-printing by FDM, but surely help researchers and industrials to start working with it.
 
DOI: http://dx.doi.org/10.30609/JETI.2020-8625