bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of flow in Rua island on Dong Nai river using 3D numerical method
Authors:   Ho Chi Minh City University of Technology, VNU-HCM, Viet Nam, Nguyen Giang Mong , Tran Hong Thi My ,   Ho Chi Minh City University of Technology, VNU-HCM, Vietnam, Vo Phu Le ,   Ho Chi Minh City University of Technology, VNU-HCM, Viet Nam, Le Giang Song ,   Ho Chi Minh City University of Technology, VNU-HCM, Viet Nam
Published: November 2023

Erosion and bank erosion are processes occurring to the riverbed and are issues closely related to the people and society. Rua Island is located in Thanh Hoi commune, Tan Uyen town, Binh Duong province which is one of serious bank erosion areas in the downstream of the Dong Nai river. Riverbank erosion in Rua islet in general has been going on for a long time and the rate of bank erosion has increased after the Tri An hydropower project came into operation and river-bed sand mining activities accelerated. At present, the Rua Islet is in danger of being cut in two at the position of Rua neck. Therefore, researching to determine the mechanism and cause of landslide of Rua Islet in order to point out effective measures to prevent landslide is urgent. A three-dimensional numerical modeling has been developed for the river section in this island to study the flow structure. This model was calibrated with observation data in 2017. Using this model flow in the entire river section was simulated. The calculation results clearly showed the three-dimensional structure of the flow at this river section, especially at the curved sections where bank erosion often occurs. Calculation results also show the distribution of bottom stresse in the river section, it is a parameter that is crucial to the process of changing of the river bed.
Developing a set of indicators to assess sustainability in land use in Tay Ninh province
Authors:   Institute for Environment and Resources, VNU-HCM, Vietnam, Trương Phú Công , Che Ly Dinh ,   Institute for Environment and Resources, VNU-HCM, Vietnam, Bui An Xuan ,   Hoa Sen University
Published: November 2023

This paper presents a study aimed at developing a set of indicators to assess the sustainability of agricultural land use applicable in Tay Ninh province. The set of directives is built based on FAO's principles of sustainable agricultural land use combined with expert knowledge, suitable to the natural - economic - social conditions of Tay Ninh province. Research and apply the AHP method to screen indicators, overcome the subjectivity and arbitrariness in choosing each indicator to participate in the assessment. The result of building a set of indicators includes 13 indicators, of which economic sector 3 indicators, social sector 5 indicators, natural resources and environment 5 indicators. Based on practical conditions, Tay Ninh province selects 4 main types of arable land use corresponding to each land unit, updates the data for the indicator set, and applies data normalization techniques by ratio. the difference brings all data to the same value, conducting a preliminary comparison of the efficiency of land use types. The development of a set of indicators can help localities have more tools and measurement methods in applying the assessment of sustainability in agricultural land use in particular and contribute to further scientific research. sustainable development in general.
Application of Attribute Recognition model to assess sustainability in land use in Tay Ninh province
Authors:   Institute for Environment and Resources, VNU-HCM, Trương Phú Công , Che Ly Dinh ,   Institute for Environment and Resources, VNU-HCM, Bui An Xuan ,   Hoa Sen University
Published: November 2023

The purpose of the article is to apply the model of identifying attributes to assess the sustainability of 4 main types of arable land use in Tay Ninh province on the basis of selecting indicators, updating data and applying statistical principles. to divide the sustainability level, use the formulas of the ARM model to calculate the hierarchy of sustainability for each facet and for aggregate stability. The economic results show that sugarcane is the most sustainable type of farming with absolute probability 1.0 and the least sustainable type is tapioca with probability 0.5. Socially, rubber, tapioca and sugarcane are most clearly shown at the very stable level with probability 0.4, respectively; 0.48 and 0.42; In terms of resources and environment, most of the four types of land use are shown at the weak and medium levels of sustainability. As a result of the combined sustainability in all three aspects of economic, social and environmental resources, sugarcane is a crop that is clearly shown at the very sustainable level, rice - color is shown at the fairly sustainable level, rubber and medium sustainable cassava. The indicators of unsustainability need to be improved according to the roadmap, in addition to the indicators that need to be maintained at a fairly sustainable level, and also pointed out 6 unsustainable causes as the main relevant factors. books, markets, science and technology, economics, society and the environment. The research results of the article will be an important scientific basis in the management and use of agricultural land in Tay Ninh province in particular and other localities in the country in general.
Artificial intelligence and the demand for skills in Russia
Authors: Ternikov A. A.
Published: November 2023

The problem of digital transformation of the labor market is widely discussed in the current scientific literature. In the context of the rapid spread of modern information technologies, in particular artificial intelligence (AI), many companies inevitably face difficulties in hiring highly qualified personnel. At the same time, research still lacks a clear understanding of the pace of AI adoption in different occupations, as well as what knowledge, skills, and abilities are actually in demand by employers. This study analyzes the demand for worker skills and the salaries offered by employers within firms, industries, and occupations. By focusing on AI skills, this paper adapts and extends the application of mainstream empirical methodology to the understudied context of the Russian labor market. The study uses data from firms and online job advertisements for the period from 2007 to 2020, and conducts econometric analysis to estimate the demand for skills. The results of the study show a rapid growth in the demand for AI skills in Russia, which is associated with significant wage premiums for these skills. However, when combined with other skills, the effect of AI skills can be negated. For example, the results suggest that basic and advanced computer skills are negatively complementary in terms of demand, which may lead to lower wages. Moreover, in the context of the Russian labor market, the demand for nontechnical skills in AI-related jobs is not associated with offering higher wages
DEVELOPING A MARKETING STRATEGY FOR ENTERING FOREIGN MARKETS
Authors: Квасова Людмила , Курбацька Лариса , Лозовий Денис
Published: November 2023

The article is dedicated to the critical aspects and strategies that businesses need to consider when expanding their operations to international markets. This article explores the essential steps and approaches that companies must take to navigate the complexities of foreign market entry successfully. Entering foreign markets is a significant endeavor for any business, and it comes with both challenges and opportunities. The main goal of this article is to provide insights, guidance, and practical recommendations for businesses that are looking to expand beyond their domestic borders. In a globalized world, expanding internationally is often seen as a necessary step for growth and sustainability. One of the key points the article delves into is the importance of a well-crafted marketing strategy. It highlights that a one-size-fits-all approach is not effective when it comes to international marketing. Instead, businesses must adapt their strategies to the unique cultural, economic, and regulatory landscapes of their target markets. The article stresses the need for thorough market research and analysis to understand consumer behavior, local competition, and market trends.
ТЕОРЕТИЧНІ ОСНОВИ ТА СУТНІСТЬ ЛОГІСТИЧНИХ ОПЕРАЦІЙ
Authors: Воробець Євген
Published: November 2023

В статті, розкрита теоретична сутність логістики та логістичних операцій в рамках сучасного етапу розвитку світової економіки загалом, та вітчизняної економіки зокрема. Розкриті підходи сучасних авторів (учених-економістів) до визначення даної категорії. Актуалізована класифікація логістичних операцій в ринковій економіці на сучасному етапі розвитку в умовах глобалізації світового економічного простору. Визначені ключові особливості логістичних операцій в українській економіці в умовах повномасштабного вторгнення російської федерації в Україну. Виявлені основні проблеми та перспективи подальшого розвитку в даній сфері в сучасних умовах воєнного стану та часткової «блокади» певних напрямів логістичних операцій з боку російської федерації. Сформульовані перспективи подальших досліджень в рамках даної науково-дослідної роботи.
УПРАВЛІННЯ ПРОЄКТНИМИ РИЗИКАМИ У СИСТЕМІ РИЗИК-МЕНЕДЖМЕНТУ ІТ-КОМПАНІЇ: ТЕОРЕТИЧНІ АСПЕКТИ
Authors: Трушкіна Наталія
Published: November 2023

У статті узагальнено й систематизовано існуючі підходи до визначення змісту та сутнісних відмінностей понять «ризик-менеджмент» та «управління ризиками». Надано авторське трактування термінів «ризик», «проєктний ризик», «управління проєктними ризиками» з позицій трансформації парадигми менеджменту та підвищення рівня економічної безпеки суб’єктів господарювання у сфері ІТ-індустрії. Запропоновано розглядати ризик-менеджмент з таких точок зору, як сучасну парадигму антикризового менеджменту ІТ-компанії; важливий чинник підвищення рівня економічної безпеки суб’єктів господарювання в ІТ-сфері; комплексний підхід до формування системи управління проєктними ризиками з урахуванням наслідків від кризових явищ та збройних конфліктів. Визначено стратегічні напрями вдосконалення управління проєктними ризиками ІТ-компаній з використанням ризик-орієнтованого підходу в умовах сучасних кризових ситуацій.
СТРАТЕГІЧНІ АСПЕКТИ ПРОЦЕСУ РОЗВИТКУ МЕНЕДЖМЕНТУ ПЕРСОНАЛУ В УМОВАХ ДІЇ ВОЄННОГО СТАНУ ТА ЇХ ВПЛИВ НА СТАН КАДРОВОГО ПОТЕНЦІАЛУ ПІДПРИЄМСТВА
Authors: Чернишова Лілія , Заложнікова Альона
Published: November 2023

В статті досліджені проблеми стратегічного розвитку менеджменту персоналу в умовах дії воєнного часу. Зазначено, що укріплення кадрового потенціалу є ключовим питанням сучасних організацій. Сформульовані основні завдання в галузі управління персоналом, які слід виконувати задля підтримки підприємств та країни під час війни. Визначено актуальні складові кадрового потенціалу з урахуванням сучасних умов дії воєнного стану. В контексті цих обставин менеджмент персоналу вимагає від керівництва підприємства адаптації до надзвичайних обставин і використання специфічних стратегій, особливі риси яких відзначені авторами. Запропоновано алгоритм вибору пріоритетних стратегічних напрямків розвитку менеджменту персоналу в умовах дії воєнного стану, який може послужити відправною точкою для розробки конкретної стратегії управління персоналом у будь-якій організації. В статті акцентовано увагу на потребі трансформаційних процесів в управлінні персоналом в умовах післявоєнної відбудови.
ЕЛЕКТРОННА ТОРГІВЛЯ ТА ІНТЕРНЕТ-ТЕХОЛОГІЇ В ЛОГІСТИЦІ
Authors: Шостак Людмила , Милько Інна , Павлова Світлана
Published: November 2023

Дана стаття присвячена ролі електронної торгівлі та інтернет-технологій в різних сферах функціональної логістики. Розвиток електронної торгівлі є наслідком цифрової трансформації суспільства, вона передбачає використання високоінтелектуальних інтернет-технологій, надає можливість споживачам швидкого задоволення власних послуг та виконання запитів. В логістичних процесах електронна торгівля займає чільне місце при купівлі сировини, матеріалів чи комплектуючих, при здійсненні розподілу продукції (вона прискорює інформування споживачів про наявність товарів чи термін їх доставки), при формуванні замовлень на складах (надає повну інформацію про наявну кількість продукції тощо. Використання інтернет-технологій в логістичній системі насамперед є досить актуальним у транспортній логістиці при складанні транспортних маршрутів із врахуванням зміни інфраструктури чи напряму руху. Авторами зазначено, що інтеграція електронної торгівлі та інтернет-технологій в логістичну систему сприятиме прискоренню здійснення бізнес-процесів логістичної системи.
РОЗРОБЛЕННЯ ТЕХНОЛОГІЇ М’ЯКОГО СИРУ З МИГДАЛЕМ
Authors: Скульська І. В. , Цісарик О. Й. , Гуменецький М. М.
Published: November 2023

Виготовлено мʼякий сир Petit-suisse із коров’ячого молока, який є високопоживним продуктом з високим вмістом молочних білків, багатий кальцієм, фосфором і жиророзчинними вітамінами, який має відмінні властивості перетравлення і засвоєння організмом людини. Це свіжий несолоний сир з гладкою текстурою. Його традиційно збагачено вершками, тому в результаті вийшов сир із жирністю близько 40%. Нашим головним завданням було вдосконалити технологію сиру Рetit-suisse та підвищити біологічну та енергетичну цінність продукту за рахунок додавання мигдалю. Даний вид сиру виготовлений за стародавнім рецептом Ольги Франко – невістки Івана Яковича Франка, яка була знатною кулінаркою свого часу на Галичині. Для коагуляції казеїну для зразку м’якого сиру використано заквашувальний препарат прямого внесення RSF-742 (Chr. Hansen, Данія), що містить у своєму складі такі штами молочнокислих бактерій: Lactococcus lactis subsp. сremoris, Lactococcus lactis subsp. lactis, Streptococcus thermophilus, Lactobacillus helveticus, а також ферментний препарат СНY-MAX виробництва фірми Chr.Hansen (Данія) та 40% водний розчин кальцію хлориду. Розроблено рецептури для виготовлення вершкового сиру з подрібненим мигдалем. Встановлені оптимальні пропорції між мигдалем і сирною основою. Рекомендуємо виробляти сир із сичужним ферментом, додаючи 10% до маси подрібненого мигдалю. Розроблено технологію виготовлення вершкового сиру. Комбінація вершкового сиру із подрібненим мигдалем надає йому унікальний смак і текстуру, що може привернути увагу і задовольнити потреби широкого кола споживачів з різними смаками, а також розширює ринок вершкових сирів в Україні. Додавання мигдалю збагатить сир не тільки специфічним смаком і ароматом, але й надасть йому функціональних оздоровчих властивостей. Виробництво вершкового сиру є економічно вигідним. Для пакування можна використати полістиролові коробочки або сиру надавати форму кульок.
АРХІТЕКТУРА ПРОГРАМНОЇ СИСТЕМИ ДЛЯ ІНТЕЛЕКТУАЛЬНОГО АСИСТЕНТА СЛУЖБИ ЮРИДИЧНОЇ ПІДТРИМКИ
Authors: Москаленко В. В. , Вербато К. Є.
Published: November 2023

В умовах Індустрії 5.0 здійснюється взаємодія людей та інтелектуальних систем у виробничій та професійній сфері, а також у приватному житті. Цифрові технології служать для вирішення завдань підвищення ефективності та продуктивності товарів і послуг, для підтримки й покращення якості життя людей. Однією з таких технологій є технологія цифрового двійника (англ – Digital Twin). Цифрові двійники дозволяють вирішувати багато складних проблем, наприклад, спрощувати процес промислового проектування; порівнювати між собою різні проекти; створювати та доповнювати технічні відомості для правильної експлуатації об'єкта; виявляти відхилення та прогнозувати збої у роботі різних за складністю приладів; скоротити витрати у логістиці та виробництві, підвищити ефективність персоналу. Розробка та впровадження технологій штучного інтелекту актуальна не лише для основних бізнес-процесів, але і для підтримуючих процесів, наприклад, для юридичного супроводу діяльності підприємства. Наведено дослідження щодо використання технологій штучного інтелекту у юридичній сфері. Було зроблено висновки щодо актуальності розробки цифрового двійника для автоматизації юридичної підтримки різних процесів підприємства. Сформовано постановку задачі розробки інтелектуального асистента, використовуючи технологію цифрового двійника, для інформаційного забезпечення та виконання певних завдань юридичної служби виробничого підприємства. Запропоновано реалізувати наступні завдання: підготовка та аналіз документації; консультування з правових питань; перевірка документації на відповідність законодавству; аналіз судових рішень для підготовки обґрунтованих рекомендацій. Розроблено архітектуру програмної системи, яка реалізує цифрового двійника – інтелектуального асистента. До основних компонент системи відносяться: інтерфейс користувача; модуль обробки мови для аналізу тексту та генерації відповідей; модуль збору та аналізу даних; модуль генерації документів та відповідей; модуль інтеграції для взаємодії між різними компонентами системи. Отже, інтелектуальний асистент може надавати юридичну підтримку, використовуючи технологію цифрового двійника, моделюючи роботу юриста. Запропоновано використовувати технології обробки природної мови NLP (англ. – Natural Language Processing) та алгоритми машинного навчання.
The Effect of Different Concentration of NaOH on Mechanical Properties of Allium sativum L. Peels Thin Sheet Paper
Authors: M YAHYA MOHAMMAD HARRIS , NASIR AHMAD ASNAWI , HASSIM NORMALA , SHAFIE AMRAN , UMOR NOOR AZRIMI , OTHMAN ZUBIR , AHMAD MOHD ROZI
Published: November 2023

Allium sativum L. peels were used as raw material to obtain cellulosic pulps for paper making. The peels were treated with sodium hydroxide at different concentrations (5%, 12.5%, and 20%) before the paper production. The sheets were measured for weight and thickness and evaluated for tensile, tear and bursting strength. The chemical compositions of the peels were analysed. The results indicated that the peels are suitable for papermaking due to the appropriate contents of cellulose (37.22%), hemicellulose (35.21%) and lignin (9.96%) values. The colour of the sheets varies from dark to light brown when the amount of sodium hydroxide solution was increased. It was estimated that the weight of peels was in the range of 5.0 - 6.5 % of garlic clove. All the sheet samples have uniform weight and thickness. The results showed that increasing sodium hydroxide concentration from 5% to 20% decreased tensile and bursting strength, except tearing strength. Two kinds of microscopic observations showed that peels treated with the highest sodium hydroxide concentration had a fine and thin layer of binder within the fibres. The sheets appear to be transparent with due to a decrease in the tensile and bursting strength except for the tear strength.
Analisis Optimasi Sistem Antrian Poli Umum Puskesmas Wonopringgo Pekalongan
Authors: Semnasti Nasyita Vivi Amalia , Semnasti Kinanti Resmi Hayati , Semnasti Isna Nugraha , Semnasti Adelia Fitriani , Semnasti Ahmad Mahendra , Semnasti M. Wildan Mufid , Semnasti Laeli Nur Istiqomah , Semnasti Jamaludin Husain , Semnasti Humam Assadilah Assalam
Published: November 2023

Antrian adalah suatu barisan manusia, benda atau hal-hal yang dapat menyebabkan menunggu. Salah satu tempat yang didalamnya ada penerapan konsep antri adalah Puskesmas Wonopringgo, tepatnya pada poli umum. Karena poli umum merupakan poli yang paling sibuk diantara yang lainnya. Untuk mengetahui seberapa efektif pola antrian pada Puskesmas Wonopringgo yaitu dengan melakukan analisa terhadap pola antrian yang ada pada poli umum Puskesmas. Analisa dimulai dengan melakukan observasi non-partisipan, model antrian yang ada pada poli umum yaitu antrian single channel single step. Hasil dan pembahasan dari sistem yang dibuat yaitu rata-rata jumlah kedatangan 14 pasien/jam, dengan rata-rata jumlah pelayanan terhadap pasien yaitu 13 pasien/jam.
Simulasi Sistem Antrian Pelayanan Penumpang Busway
Authors: Rahmawati Nur , Donoriyanto Dwi Sukma
Published: November 2023

Antrian adalah suatu permasalahan yang terjadi ketika jumlah pelanggan lebih banyak dibanding dengan jumlah sumber daya yang ada pada pelayanan, sehingga menyebabkan pelanggan menunggu sebelum dilayani. Permasalahan yang terjadi pada penumpang busswayy di halte yaitu tempat dimana terjadinya antrian pada saat menunggu kedatangan bus dan antri saat masuk ke dalam bus. Hal ini dikarenakan akibat jumlah sumber daya pelayanan yang tersedia tidak sebanding dengan jumlah pelanggan yang ada. Simulasi adalah kegiatan mereproduksi perilaku sistem, menggunakan model yang menggambarkan atau merepresentasikan proses dari sistem nyata yang bersangkutan. Simulasi dilakukan menggunakan software Arena untuk menggambarkan kegiatan produksi dalam sistem pelayanan sesuai sistem yang ada. Setelah dilakukan pengolahan data dengan software Arena maka diapatkan semua proses mempunyai nilai 1. Dari hasil verifikasi dan validasi didapat, H0 diterima, karena nilai 0 berada didalam pada rentang μ1 – μ2 sehingga dapat dikatakan valid. Karena data yang dihasilkan valid maka hasil simulasi dapat digunakan pada sistem produksi yang sesungguhnya.
Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma
Authors: De Coninck Stien , De Smedt Renate , Lintermans Beatrice , Reunes Lindy , Kosasih Hansen J. , Reekmans Alexandra , Brown Lauren M. , Van Roy Nadine , Palhais Bruno , Roels Juliette , Van der Linden Malaika , Van Dorpe Jo , Ntziachristos Panagiotis , Van Delft Frederik W. , Mansour Marc R. , Pieters Tim , Lammens Tim , De Moerloose Barbara , De Bock Charles E. , Goossens Steven , Van Vlierberghe Pieter
Published: November 2023

T cell acute lymphoblastic leukemia (T-ALL) and T cell lymphoblastic lymphoma (T-LBL) are rare aggressive hematological malignancies. Current treatment consists of intensive chemotherapy, leading to 80% overall survival but are associated with severe toxic side effects. Furthermore, 10-20% of patients still die from relapsed or refractory disease providing a strong rationale for more specific, targeted therapeutic strategies with less toxicities. Here, we report a novel MYH9::PDGFRB fusion in a T-LBL patient and demonstrate that this fusion product is constitutively active and sufficient to drive oncogenic transformation in vitro and in vivo. Expanding our analysis more broadly across T-ALL, we found a T-ALL cell line and multiple patient derived xenograft models with PDGFRB hyperactivation in the absence of a fusion, with high PDGFRB expression in TLX3 and HOXA T-ALL molecular subtypes. To target this PDGFRB hyperactivation, we evaluated the therapeutic effects of a selective PDGFRB inhibitor, CP-673451, both in vitro and in vivo and demonstrated sensitivity if the receptor is hyperactivated. Altogether, our work reveals that hyperactivation of PDGFRB is an oncogenic driver in T-ALL/T-LBL and that screening T-ALL/TLBL patients for phosphorylated PDGFRB levels can serve as a biomarker for PDGFRB inhibition as a novel targeted therapeutic strategy in their treatment regimen.
FORMAÇÃO DE PROFESSORES NA PERPECTIVA DE PAULO FREIRE, ANTÔNIO NÓVOA E MAURICE TARDIF
Authors: Silva Robson Rafael da , Kanan Lilia Aparecida , Silva Cinthia Lopes
Published: November 2023

Com este texto objetiva-se apresentar a concepção dos teóricos Paulo Freire, Antônio Nóvoa e Maurice Tardif referente a formação de professores. Trata-se de um estudo bibliográfico, de natureza qualitativa, com características descritiva e exploratória. Para a escrita do presente artigo foram selecionadas 14 obras dos autores que importam e guardam relação ao seu objetivo.  Como resultado das análises destaca-se que os teóricos em tela defendem uma formação mais eficaz e ativa através de práticas colaborativas, da troca de saberes e ideias que sejam contributivas no processo formativo e consequentemente nas atividades que serão desenvolvidas futuramente com os educandos. Os teóricos concebem que a troca de saberes é uma perspectiva norteadora e benéfica para o futuro egresso. Além disso, os autores destacam a necessidade de repensarmos o modelo tradicional de formação de professores e promovermos uma abordagem mais reflexiva e crítica. Eles argumentam que a formação de professores deve ser um processo contínuo, que envolve a integração entre a universidade e a prática escolar. Essa abordagem tem o potencial de fortalecer a identidade profissional dos professores, tornando-os agentes de mudança e intelectuais engajados na transformação da educação.
Palavras-chave: Formação de professores. Educação. Cultura. Sociedade.
 
ABSTRACT
This text object presents the concept of teóricos Paulo Freire, Antônio Nóvoa and Maurice Tardif referring to the training of professors. Trata-se de um estudo bibliográfico, de natureza qualitativa, com characterísticas descritiva e exploratória. To write this article, we have selected 14 articles from the authors that are important and protected in relation to their subject matter. As a result of the analyzes destaca-se that our teóricos em such a defendem a training but effective and active through collaborative practices, of troca of sabers and ideas that are contributing no processo formativo and consequently our activities that will be developed in the future with our educandos. We believe that the trade of swords is a norteadora perspective and benefits for future growth. Além disso, our authors destacam a necessidade de rethinks our traditional model of training of professors and we promote an approach but reflective and critical. The argument that the training of professors must be a continuous process, which involves integration between university and academic practice. Try to approach the potential to advance the professional identity of professors, to turn our agents of knowledge and intellect into the transformation of education.
Palavras-chave: Training of professors. Education. Culture. Society.
Exploring Consumer Demand in Women’s Professional Basketball
Authors: Johnson Lauren M. , Bo Hannah H.
Published: November 2023

This research aimed to conceptualize the relationships between consumer demand and WNBA spectatorship from the Stimulus-Organism-Response perspective to better understand what product features of WNBA events impact consumption. As a league that fully embraces fan engagement through social justices initiatives, we do not know what specific core product features in the contemporary landscape of the WNBA lead to high perceptions of product quality and increased consumer demand. The Conceptual Framework of Consumer Demand for Core Product Features of the WNBA Live Game introduces Interactive Activity and Advocacy Programming as a way to understand the unique environmental features of WNBA consumption.
Retribution and Regional Tax Receipts on Economic Growth Through Regional Expenditures as an Intervening Variable
Authors: Sugiarto Edy , Klaudia Sura , Munaroh Munaroh
Published: November 2023

This study aims to determine the relationship between regional taxes and economic growth, regional levies and economic growth, regional taxes and economic growth through regional expenditures as an intervening variable, and regional levies and economic growth through regional expenditures as an intervening variable. The population in this study consisted of the Probolinggo Regency APBD, regional fees, regional gross domestic product at constant prices, and local tax reports. The Probolinggo Regency APBD in one decade (2012-2021) consisted of 40 samples from all variables, namely all regional tax reports, regional levies, regional gross domestic product, and the samples in this study. I obtained secondary data from the Central Bureau of Statistics (BPS) of Probolinggo Regency. The analysis technique uses SPSS 25, and the test results show that regional taxes have an effect on economic growth, regional levies do not, regional taxes moderated by regional spending have an effect, and regional levies moderated by regional expenditures have an effect on economic growth. Keywords: Regional Tax, Regional Retribution, Regional Expenditure, Economic Growth.
IDENTIFICATION OF TRIARYLMETHANE, PHTHALOCYANINE AND XANTHENE IN A MIXTURE OF DYES BY ELECTRON ABSORPTION SPECTROSCOPY
Authors: Posilskyi Oleg , Artamonova Ganna , Trunova Elena
Published: November 2023

In the work, the qualitative composition and differentiation of 43 samples of ballpoint pen pastes of different colors was investigated (blue-violet – 29 samples, pink-violet – 3 samples, blue – 3 samples, black – 5 samples, green – 1 sample and red –2 samples) by the method of electronic absorption spectroscopy. The results of the study showed that each paste can be distinguished by studying the nature of their absorption spectra, which arises due to the presence of different functional groups. It was established that most of the analyzed paste samples contain pigments based on triarylmethane, phthalocyanine, xanthene dyes or their mixture. Certain absorption maxima correspond to each type of dyes. The broad and most intense band at λ~590 nm, which was detected for all samples, corresponds to triarylmethane dyes. The band at λ~670 nm corresponds to phthalocyanine dyes. The presence of absorption bands in the green range (λ~520–560 nm) indicates the presence of xanthene dyes in the composition of the pastes. Using the method of photoluminescence spectroscopy upon exci­tation of IR luminescence in the green region of the spectrum (λ=530 nm) it is shown that 11 blue-violet, 5 black and one red pastes exhibit bright luminescence due to the presence of crystal violet and some other triarylmethane dyes in their composition. Weak luminescence was detected for three blue pastes. No luminescence response was observed for the other tes­ted pastes, which is due to the presence of phthalocyanine dyes in these pastes, the absorption of which overlaps with the luminescence spectra of triarylmethane dyes. The obtained data can be used to create a reference base for identifying and differentiating the composition of ballpoint pen pastes of modern manufacturers and establishing their classification and identification differences.
Skin microbiome and possibilities of bacteriotherapy (on example of skin aging and atopic dermatitis)
Authors: Smirnova I. O. , Khazhomiya K. D. , Ptashnikova P. D. , Smirnova O. N.
Published: November 2023

Currently, the microbial community of the skin is considered as a dynamic functional system that develops synergistically with the body in general and the skin in particular, participates in the regulation and implementation of its functions, contributes to skin aging and the pathogenesis of chronic inflammatory dermatoses. Understanding the contribution of skin dysbiosis to skin aging and the pathogenesis of chronic dermatoses has provided the basis for the development of strategies aimed at correcting the skin microbiota, or bacteriotherapy. The latter includes the use of allogeneic or autologous living bacteria, as well as inactivated microorganisms, components of their cell wall, signaling molecules and metabolites. The latter are included in products for external use, including dermatocosmetics. Among the bacteria that are considered as potential sources of active ingredients for cosmetics, lactic acid bacteria deserve special attention. Not only are they members of the normal microbiota of the skin and gastrointestinal tract and produce antimicrobial compounds such as organic acids and bacteriocins, but they are also widely used as probiotics. The article discusses the importance of the skin microbiota for the implementation of its functions normally, including in the age aspect, as well as the prospects for using methods of bacteriotherapy with products for external use containing inactivated Lactobacillus, Lactococcus, Bifidobacterium and the prebiotics inulin and trehalose, using the example of atopic dermatitis and age-related skin changes.
Efficacy and safety of isotretinoin Lidose®
Authors: Kruglova L. S. , Gryazeva N. V. , Tamrazova A. V.
Published: November 2023

Introduction. Acne is a common chronic inflammatory disease, which is accompanied by severe social stress and reduces the quality of life of patients. Isotretinoin is the gold standard for the treatment of severe and moderate forms of acne, and is also used when there is a risk of developing a post-acne symptom complex and when previous treatment methods are ineffective.

Purpose of the study. To determine the effectiveness and safety of various isotretinoin regimens at a dose of 0.4–0.8 mg/kg in patients with moderate to severe acne vulgaris and in patients with adult acne.

Materials and methods. A single-center, prospective, parallel, controlled study involved 139 patients with acne vulgaris and adult acne, who were divided into 3 groups. 72 patients with acne vulgaris of moderate severity according to the IGA scale (group A1) and 37 patients with adult acne (group B) received isotretinoin (Accutane) at a dose of 0.4 mg/kg/day (cumulative dose 100 mg/kg) for 8 months. 30 patients with severe forms of acne vulgaris (group A1) received Accutane at a dose of 0.8 mg/kg/day (cumulative dose 120 mg/kg) for 8 months. The study lasted 24 months. and consisted of 4 visits (1st visit, 4, 8 and 24 months), at each visit photocontrol was performed, the number of inflammatory and non-inflammatory elements was calculated, the DAI index and the degree on the IGA scale were determined.

Results. All 139 patients achieved ‘clear’ or almost ‘clear’ skin according to the IGA scale after 8 months of therapy. There was also a statistically significant decrease in non-inflammatory and inflammatory elements in all groups after 4 and 8 months. (p < 0.001). The total DIA score after 8 months was reduced in group A1 by 89.2%, in group A2 by 83.78% and in group B by 80.3%. Acne recurrence after 24 months was determined in five patients.

Conclusions. Various regimens of Accutane for moderate and severe acne vulgaris, as well as adult acne, have demonstrated high efficacy and a favorable safety profile.
Combined use of microneedle radiofrequency lifting and injectable fillers based on hyaluronic acid in treatment of involutive changes in facial skin
Authors: Gres S. N. , Gryazeva N. V.
Published: November 2023

Combined procedures can be performed during one appointment to solve several problems for the patient. However, some treatments should be planned over several consecutive sessions to avoid complications and achieve optimal results. The purpose of our study was the scientific substantiation and development of an algorithm for the complex use of microneedle radiofrequency lifting and injection fillers based on hyaluronic acid in patients with involutive changes in the facial skin, taking into account the data of the pathomorphological research method. The patients were divided into three groups, depending on the treatment methods. In order to assess the effectiveness of therapy, a histological examination was carried out in five patients from each group, and a morphometric assessment was carried out. The histological picture and morphometric assessment of microslides from patients from different study groups indicate that microneedle RF lifting entails scar-type changes, which thins the thickness of the epidermis. However, the use of hyaluronic acid smoothes out these changes and leads to faster tissue restoration. At the same time, in the complex treatment group, better regenerative potential was noted than in the monotherapy groups, which is confirmed by the maximum value of basal epidermocytes per unit length.
Skin microbiome in acne and role of dermatocosmetics in complex treatment (literature review)
Authors: Kruglova L. S. , Gryazeva N. V. , Verbovaya E. D.
Published: November 2023

In acne, a microbial imbalance compared to a normal distribution in healthy tissues is thought to be involved in the pathophysiology of inflammatory acne. Extended metagenomic sequencing has shown that the skin microbiota of acne patients differs from the microbiota of people without acne at the level of a virulent-specific lineage. Acquired DNA sequences and bacterial immune elements may be involved in the virulence of C. acnes strains. Acne-associated strains produce significantly higher levels of pro-inflammatory metabolites, porphyrins, which generate reactive oxygen species and induce inflammation in keratinocytes. In light of these data, restoration of the skin microbiome in acne is one of the main goals of therapy. Specialized cosmetics that allow restoring skin microbiocenosis is a pathogenetically substantiated option for the complex treatment of patients with acne. To solve this problem, the scientists of the laboratory of La Roche-Posay have created an innovative range of products EFFACLAR H ISO-BIOME. The products effectively reduce all side effects caused by the use of topical and systemic drugs, and also normalize the skin microbiome by activating the growth of commensal microorganisms.
Evaluation of effectiveness of complex therapy for limited eczematous (spongiotic) dermatosis in children and adolescents using local low-frequency magnetotherapy
Authors: Iskra A. S. , Iskra E. L. , Suslova G. A. , Zaslavsky D. V.
Published: November 2023

The search for modern and affordable methods for the treatment of dermatoses remains an urgent problem in domestic dermatology. The results of recent studies indicate the high therapeutic efficacy of various types of magnetotherapy. The course application of a local low-frequency magnetic field reduces the inflammatory response and helps to restore the structure of the epidermis and dermis in the affected areas of the skin.

Purpose of the study. To study the safety and efficacy of local magnetic therapy in a limited form of spongiotic dermatosis with a violation of the skin barrier in children and adolescents.

Material and methods. The study involved 44 children aged 5 to 16 years. The patients were divided into two groups: the first group combined external therapy and local low-frequency magnetotherapy, the patients of the second group received external therapy and placebo in physiotherapy treatment.

Results. According to the study, the efficacy and safety of local magnetic therapy in focal pruritic dermatosis in combination with basic external agents and a faster treatment result with prolonged remission are confirmed.

Conclusions. The use of local magnetic therapy in combination with standard external therapy contributes to the relief of clinical symptoms of local eczematous dermatosis and improves the quality of life of patients.
Structure of pathology in vulva area
Authors: Surkichin S. I. , Kruglova L. S. , Apolikhina I. A.
Published: November 2023

This article describes the structure of morbidity in the vulvar area in women 45–72 years old, and analyzes the frequency of discrepancies in diagnoses among dermatovenerologists and gynecologists. It has been established that nonspecific vulvitis / vulvovaginitis (23%), lichen sclerosus (20%), genitourinary menopausal syndrome (20%), contact dermatitis (12%), lichen planus (7%), atopic dermatitis (6%), vulvar itching (5%), psoriasis (2%) predominate in the structure of vulvar pathology in women.
Innovative complex method of therapy of hypertrophic skin scars
Authors: Nogerov A. P. , Kruglova L. S. , Stenko A. G. , Manturova N. E.
Published: November 2023

Many methods of therapy for GR are currently insufficiently studied in terms of a high evidence base, and the data are contradictory, which determinesthe relevance of research aimed at developing and studying the effectiveness and safety of new methods that can influence the main links in thepathogenesis of pathological scars. The aim of our study was to scientifically substantiate and develop a combined method of therapy for patients withsevere hypertrophic scars lasting up to 1 year using a neodymium laser and pneumokinetic therapy with 5-fluorouracil and durant corticosteroid basedon a study of hemodynamic processes. The study group included 34 patients with hypertrophic scars who underwent two procedures of pneumokinetictherapy with GCS and 5-FU, with an interval of two months. After another one month, laser therapy with a neodymium laser (1064nm) was performed.The results of the LDF study confirmed the early results obtained on the initial changes in the microcirculatory bed in hypertrophic scars, as well as dataon the high efficiency of the developed method of pneumokinetic therapy of GCS + 5-FU and the sequential use of a neodymium laser (1064 nm).
Minolexin® in complex therapy of papulo-pustular acne of moderate severity (results of own research)
Authors: Khismatulina I. M.
Published: November 2023

The aim of the study. A retrospective analysis of the results of complex therapy of moderate papulo-pustular acne with minocycline 50 mg per day orally and 15 % azelaic acid gel topically under natural ultraviolet irradiation.

Materials and methods. In a retrospective study, data from outpatient charts and the results of studying the morpho-functional parameters of the facial skin of 61 people (31 acne patients and 30 healthy individuals) were analyzed. Patients received oral minocycline (Minolexin®) 50 mg per day for 6 weeks and topically 15 % azelaic acid gel 2 times a day for 12 weeks in the period from April to September.

Results and discussion. The therapy was effective: clinical cure occurred in 90.3 % (n = 28), clinical remission – in 9.7 % (n = 3) patients. Rapid regression of papulo-pustules was achieved through the use of minocycline, which had antibacterial and anti-inflammatory effects. After treatment, elevated values of sebumetry, skin relief, pore size, and pigmentation were normalized in the group of patients with acne, due to the action of a topical gel, as well as the absence of photosensitizing effect in minocycline. Systemic and local adverse events registered in outpatient records were of a temporary nature and did not require discontinuation of therapy.
Analysis of duration of remission of psoriasis after discontinuation of targeted therapy: Search for predictors of early relapse of disease
Authors: Khotko A. A. , Murashkin N. N.
Published: November 2023

Purpose of the study. To establish patterns of changes in the duration of the remission period in patients suffering from severe psoriasis after discontinuation of targeted therapy.

Materials and methods. The work was carried out in the design of an open randomized interventional prospective study and was carried out in two successive stages. To calculate indicators of the expected duration of the remission period, Kaplan – Meier ‘survival’ analysis was used with the construction of ‘survival’ tables and curves assessing the significance of differences using the Mantel – Cox log-rank test. Significant factors presumably influencing the increase in the cumulative risk of relapse were determined by multivariate Cox regression.

Results. The longest period of remission was typical for patients who were prescribed systemic therapy with guselkumab – 33.5 weeks, the second longest period of remission was ustekinumab – 29.1 weeks, the third – secukinumab – 24.7 weeks. The average duration of remission after discontinuation of adalimumab used for a year was 17.4 weeks. The worst disease-free period was recorded for apremilast – 6.9 weeks (p < 0.001 for all comparisons). Significant predictors of early onset of psoriasis relapse were the following factors: the presence of a family history, failure to achieve the PASI 75 indicator by the 16th week of treatment, delayed prescription of targeted therapy (more than 3 years after the diagnosis of ‘severe psoriasis vulgaris’), high values of the PASI index at the time of initiation of systemic therapy and long duration of illness.

Conclusions. Resumption of systemic treatment was required in 25.8 %, 35.3 %, and 12.1 % of patients within the first 6 months after discontinuation of ustekinumab, secukinumab, and guselkumab, respectively. When patients received adalimumab, re-prescription of targeted therapy was required in 33.3 % of cases 4 months after discontinuation, and when prescribed apremilast – in 64.5 % of cases already 2 months after discontinuation. Among all systemic drugs examined, the IL‑23 inhibitor (guselkumab) was associated with the longest period of psoriasis remission after discontinuation of targeted treatment. The identified predictors of early disease relapse indicate the importance of personalized targeted therapy and open up the possibility of prognostic assessment of the expected duration of the disease-free period after discontinuation of systemic treatment.
Clinical demonstration of patient with inflammatory bowel disease
Authors: Uspensky Yu. P. , Fominykh Yu. A. , Kizimova O. A. , Minina O. S. , Zavitaeva A. P.
Published: November 2023

A 27-year-old patient was transferred by an infectious disease doctor to the St. Petersburg Elizabethan Hospital with a long history of diarrhea and intoxication syndrome. A detailed examination revealed an infection with Clostridium difﬁcile, which contributed to the progression of the disease, deterioration of well-being and, as a result, an increase in neuroticism. The clinical and endoscopic picture indicated ulcerative colitis. When reviewing the biopsy material, noncaseating epithelioid cell granulomas were found, which conﬁrmed the diagnosis of Crohn's disease. This case demonstrates the complexity of the differential diagnosis of inﬂammatory bowel diseases, which determines the tactics of patient management.
Stiffness, elasticity, resilience, density as clinical interpretation of physical properties of liver tissue
Authors: Borsukov A. V. , Venidiktova D. Yu. , Smirnova A. D. , Yakusheva M. A.
Published: November 2023

Objective. Evaluation of a single vector of ultrasound assessment of changes in the liver parenchyma, taking into account the correct use of such physical concepts as stiffness, elasticity, elasticity, density.

Material and methods. On the basis of the Problem Research Laboratory ‘Diagnostic Research and Minimally Invasive Technologies’ a study was conducted with the participation of 112 patients of a multidisciplinary hospital. Multiparametric ultrasound examination (B-mode, quantitative liver steatometry, 2D shear wave elastography, complex format ‘liver protocol’) was performed by ultrasound doctors (n = 24) of the following groups: half-a-year residents in the specialty ‘ultrasound diagnostics’ (n = 9; 37.6%), doctors working in a multidisciplinary hospital of a medical organization of the regional center with work experience up to 5 years (n = 4; 16.6%), 6–10 years (n = 4; 16.6%), 11–20 years old (n = 3; 12.6%), 21 years or more (n = 4; 16.6%), of which 1 (4.2%) professor, 1 (4.2%) doctor of medical sciences, 3 (12.5%) candidates of medical sciences. An analysis of the protocols of ultrasound examination was carried out.

Results.The correct description of changes in the liver according to B-mode data, quantitative steatometry, 2D shear wave elastography and ‘liver protocol’ correct formulations were given by 9 (37.5%) specialists. In all cases, most of the correct protocols were provided by doctors from groups of 6–10 years of experience and 21 years of experience or more.

Conclusions. In the community of specialists in ultrasound diagnostics there is no agreement on a correct and uniﬁed approach to the description of diffuse liver changes using multiparametric ultrasound. To increase the level of knowledge, complex multidisciplinary interaction is necessary in the format of scientiﬁc and educational programs organized jointly with specialists in the ﬁeld of medical physics.
Role of chronic constipation in development of cardiovascular pathology
Authors: Ivanyuk E. S. , Seliverstov P. V. , Salikova S. P. , Kutsenko V. P.
Published: November 2023

Today, constipation is one of the most important medical and social problems of world health. Its prevalence, according to various estimates, exceeds 30%. There is no doubt that this pathology precedes the occurrence of a number of diseases and not only of the gastrointestinal tract. For example, studies conducted at La Trobe University in Australia have shown a link between chronic constipation and the development of cardiovascular diseases. In the management of a patient suffering from chronic constipation, in addition to knowledge about the regulation of intestinal secretion and motility, recognition and possible elimination of the cause of its development, the choice of therapy tactics, taking into account concomitant diseases, especially in the presence of pathology from the cardiovascular system, is of great importance. In the treatment regimens, it is customary to use drugs with a laxative effect and different mechanisms of their action, allowing achieving a rapid positive effect in a short time.