bluuebunny/crossref_metadata_2025 huggingface dataset:
Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis
Authors: Døsen Guri , Tenstad Ellen , Nygren Marit Kveine , Stubberud Heidi , Funderud Steinar , Rian Edith
Published: August 2006

Background

The early B lymphopoiesis in mammals is regulated through close interactions with stromal cells and components of the intracellular matrix in the bone marrow (BM) microenvironment. Although B lymphopoiesis has been studied for decades, the factors that are implicated in this process, both autocrine and paracrine, are inadequately explored. Wnt signaling is known to be involved in embryonic development and growth regulation of tissues and cancer. Wnt molecules are produced in the BM, and we here ask whether canonical Wnt signaling has a role in regulating human BM B lymphopoiesis.

Results

Examination of the mRNA expression pattern of Wnt ligands, Fzd receptors and Wnt antagonists revealed that BM B progenitor cells and stromal cells express a set of ligands and receptors available for induction of Wnt signaling as well as antagonists for fine tuning of this signaling. Furthermore, different B progenitor maturation stages showed differential expression of Wnt receptors and co-receptors, β-catenin, plakoglobin, LEF-1 and TCF-4 mRNAs, suggesting canonical Wnt signaling as a regulator of early B lymphopoiesis. Exogenous Wnt3A induced stabilization and nuclear accumulation of β-catenin in primary lineage restricted B progenitor cells. Also, Wnt3A inhibited B lymphopoiesis of CD133+CD10-hematopoietic progenitor cells and CD10+B progenitor cells in coculture assays using a supportive layer of stromal cells. This effect was blocked by the Wnt antagonists sFRP1 or Dkk1. Examination of early events in the coculture showed that Wnt3A inhibits cell division of B progenitor cells.

Conclusion

These results indicate that canonical Wnt signaling is involved in human BM B lymphopoiesis where it acts as a negative regulator of cell proliferation in a direct or stroma dependent manner.
Impact of DOTS expansion on tuberculosis related outcomes and costs in Haiti
Authors: Jacquet Vary , Morose Willy , Schwartzman Kevin , Oxlade Olivia , Barr Graham , Grimard Franque , Menzies Dick
Published: August 2006

Background

Implementation of the World Health Organization's DOTS strategy (Directly Observed Treatment Short-course therapy) can result in significant reduction in tuberculosis incidence. We estimated potential costs and benefits of DOTS expansion in Haiti from the government, and societal perspectives.

Methods

Using decision analysis incorporating multiple Markov processes (Markov modelling), we compared expected tuberculosis morbidity, mortality and costs in Haiti with DOTS expansion to reach all of the country, and achieve WHO benchmarks, or if the current situation did not change. Probabilities of tuberculosis related outcomes were derived from the published literature. Government health expenditures, patient and family costs were measured in direct surveys in Haiti and expressed in 2003 US$.

Results

Starting in 2003, DOTS expansion in Haiti is anticipated to cost $4.2 million and result in 63,080 fewer tuberculosis cases, 53,120 fewer tuberculosis deaths, and net societal savings of $131 million, over 20 years. Current government spending for tuberculosis is high, relative to the per capita income, and would be only slightly lower with DOTS. Societal savings would begin within 4 years, and would be substantial in all scenarios considered, including higher HIV seroprevalence or drug resistance, unchanged incidence following DOTS expansion, or doubling of initial and ongoing costs for DOTS expansion.

Conclusion

A modest investment for DOTS expansion in Haiti would provide considerable humanitarian benefit by reducing tuberculosis-related morbidity, mortality and costs for patients and their families. These benefits, together with projected minimal Haitian government savings, argue strongly for donor support for DOTS expansion.
Risk adjustment for inter-hospital comparison of primary cesarean section rates: need, validity and parsimony
Authors: Fantini Maria P , Stivanello Elisa , Frammartino Brunella , Barone Anna P , Fusco Danilo , Dallolio Laura , Cacciari Paolo , Perucci Carlo A
Published: August 2006

Background

Cesarean section rates is often used as an indicator of quality of care in maternity hospitals. The assumption is that lower rates reflect in developed countries more appropriate clinical practice and general better performances. Hospitals are thus often ranked on the basis of caesarean section rates.

The aim of this study is to assess whether the adjustment for clinical and sociodemographic variables of the mother and the fetus is necessary for inter-hospital comparisons of cesarean section (c-section) rates and to assess whether a risk adjustment model based on a limited number of variables could be identified and used.

Methods

Discharge abstracts of labouring women without prior cesarean were linked with abstracts of newborns discharged from 29 hospitals of the Emilia-Romagna Region (Italy) from 2003 to 2004. Adjusted ORs of cesarean by hospital were estimated by using two logistic regression models: 1) a full model including the potential confounders selected by a backward procedure; 2) a parsimonious model including only actual confounders identified by the "change-in-estimate" procedure. Hospital rankings, based on ORs were examined.

Results

24 risk factors for c-section were included in the full model and 7 (marital status, maternal age, infant weight, fetopelvic disproportion, eclampsia or pre-eclampsia, placenta previa/abruptio placentae, malposition/malpresentation) in the parsimonious model. Hospital ranking using the adjusted ORs from both models was different from that obtained using the crude ORs. The correlation between the rankings of the two models was 0.92. The crude ORs were smaller than ORs adjusted by both models, with the parsimonious ones producing more precise estimates.

Conclusion

Risk adjustment is necessary to compare hospital c-section rates, it shows differences in rankings and highlights inappropriateness of some hospitals. By adjusting for only actual confounders valid and more precise estimates could be obtained.
Staffing in postnatal units: is it adequate for the provision of quality care? Staff perspectives from a state-wide review of postnatal care in Victoria, Australia
Authors: Forster Della A , McLachlan Helen L , Yelland Jane , Rayner Jo , Lumley Judith , Davey Mary-Ann
Published: August 2006

Background

State-wide surveys of recent mothers conducted over the past decade in Victoria, one state of Australia, have identified that women are consistently less satisfied with the care they received in hospital following birth compared with other aspects of maternity care. Little is known of caregivers' perspectives on the provision ofhospital postnatal care: how care is organised and provided in different hospitals; what constrains the provision of postnatal care (apart from funding) and what initiatives are being undertaken to improve service delivery. A state-widereview of organisational structures and processes in relation to the provision of hospital postnatal care in Victoria was undertaken. This paper focuses on the impact of staffing issues on the provision of quality postnatal care from the perspective of care providers.

Methods

A study of care providers from Victorian public hospitals that provide maternity services was undertaken. Datawere collected in two stages. Stage one: a structured questionnaire was sent to all public hospitals in Victoria that provided postnatal care (n = 73), exploring the structure and organisation of care (e.g. staffing, routine observations, policy framework and discharge planning). Stage two: 14 maternity units were selected and invited to participate in a more in-depth exploration of postnatal care. Thirty-eight key informant interviews were undertaken with midwives (including unit managers, associate unit managers and clinical midwives) and a medical practitioner from eachselected hospital.

Results

Staffing was highlighted as a major factor impacting on the provision of quality postnatal care. There were significant issues associated with inadequate staff/patient ratios; staffing mix; patient mix; prioritisation of birth suites over postnatal units; and the use of non-permanent staff. Forty-three percent of hospitals reported having only midwives (i.e. no non-midwives) providing postnatal care. Staffing issues impact on hospitals' ability to provide continuity of care. Recruitment and retention of midwives are significant issues, particularly in rural areas.

Conclusion

Staffing in postnatal wards is a challenging issue, and varies with hospital locality and model of care. Staff/patient ratios and recruitment of midwives in rural areas are the two areas that appear to have the greatest negative impact on staffing adequacy and provision of quality care. Future research on postnatal care provision should include consideration of any impact on staff and staffing.
Swiss residents' arguments for and against a career in medicine
Authors: Buddeberg-Fischer Barbara , Dietz Claudia , Klaghofer Richard , Buddeberg Claus
Published: August 2006

Background

In some Western countries, the medical profession is continuously losing prestige, doctors are claiming of high demands, low rewards, and difficult structural working conditions. This study aimed to investigate the arguments given by Swiss residents for and against a career in medicine.

Methods

As part of a prospective cohort study of Swiss medical school graduates on career development, 567 fourth-year residents were asked to answer the free-response item of what arguments there still were in favour of or against a career in medicine. They also indicated whether they would choose the medical profession all over again (yes/no). The statements were transcribed, content categories inductively formulated, and their descriptions written down in a code manual. Arguments were encoded according to the code manual and assigned to eight content categories (Mayring's content analysis). Frequency distributions were given for categories and tested with Chi2-tests for differences in gender, speciality fields, and whether or not the respondent would again choose a career in medicine.

Results

The 567 participants made 1,640 statements in favour of and 1,703 statements against a career in medicine. The content analysis of the residents' answers yielded eight categories with arguments both for and against a career in medicine. Of all "statements for" responses, 70% fell into the two top-ranking categories ofPersonal experiences in day-to-day working life (41.2%)andInterpersonal experiences in professional relationships (28.8%). The top-ranking category of the "statements against" arguments wasGeneral work-related structural conditions (32%), followed bySocial prestige and health-policy aspects (21%). Main arguments in favour of a career in medicine were interdisciplinary challenge, combination of basic sciences and interpersonal concerns, helping suffering people, guarantee of a secure job; arguments against comprised high workload, time pressure, emotional stress, poorly structured continuing education, increasing bureaucracy, work-life imbalance, low income, and decreasing social prestige. The statements revealed few differences depending on gender, medical field, and attitude towards choosing the medical profession again; one out of five young doctors would not do so.

Conclusion

Residents' chief complaint is deteriorating structural working conditions, including unfavourable work-life balance. Making medicine an attractive profession again will require sustainable changes in health-policy framework and social reward.
The time course of subsequent hospitalizations and associated costs in survivors of an ischemic stroke in Canada
Authors: Caro J Jaime , Migliaccio-Walle Kristen , Ishak Khajak J , Proskorovsky Irina , O'Brien Judith A
Published: August 2006

Background

Documentation of the hospitalizations rates following a stroke provides the inputs required for planning health services and to evaluate the economic efficiency of any new therapies.

Methods

Hospitalization rates by cause were examined using administrative data on 18,695 patients diagnosed with ischemic stroke (first or subsequent, excluding transient ischemic attack) in Saskatchewan, Canada between 1990 and 1995. Medical history was available retrospectively to January 1980 and follow-up was complete to March 2000. Analyses evaluated the rate and timing of all-cause and cardiovascular hospitalizations within discrete periods in the five years following the index stroke. Cardiovascular hospitalizations included patients with a primary diagnosis of ischemic stroke, transient ischemic attack, myocardial infarction, stable or unstable angina, heart failure or peripheral arterial disease.

Results

One-third (36%) of patients were identified by a hospitalized stroke. Mean age was 70.5 years, 48.0% were male, half had a history of stroke or a transient ischemic attack at the time of their index stroke. Three-quarters of the patients (72.7%) were hospitalized at least once during a mean follow-up of 4.6 years, accruing CAD $24 million in the first year alone. Of all hospitalizations, 20.4% were related to cardiovascular disease and 1.6% to bleeds. In the month following index stroke, 12.5% were admitted, an average of 1.04 times per patient hospitalized. Strokes accounted for 33% of all hospitalizations in the first month. The rate diminished steadily throughout the year and stabilized in the second year when approximately one-third of patients required hospitalization, at a rate of about one hospitalization for every two patient-years. Mean lengths of stay ranged from nine days to nearly 40 days. Close-fitting Weibull functions allow highly specific probability estimates. Other cardiovascular risk factors significantly increased hospitalization rates.

Conclusion

After stroke, there are frequent hospitalizations accounting for substantial additional costs. Though these rates drop after one year, they remain high over time. The number of other cardiovascular causes of hospitalization confirms that stroke is a manifestation of disseminated atherothrombotic disease.
Compliance of young children with ITN protection in rural Burkina Faso
Authors: Frey Claudia , Traoré Corneille , De Allegri Manuela , Kouyaté Bocar , Müller Olaf
Published: August 2006

Background

Insecticide-treated bed nets (ITNs) are known to be highly effective in reducing malaria morbidity and mortality. The effectiveness of ITNs is largely influenced by behavioural factors and not much is known regarding such factors under programme conditions.

Methods

This descriptive study was nested into a large ITN effectiveness study in rural Burkina Faso. During two cross-sectional surveys in the dry and rainy season of 2003, random samples of young children from nine representative villages (n = 180 per survey) were investigated for compliance with ITN protection and related behaviour. Data were collected through direct observations and through interviews with mothers.

Results

ITNs were perceived as very important for protection against mosquitoes and malaria particularly during the rainy season, but there were problems with their use during the dry season. Young children usually slept with their mother under the ITN and self-reported compliance was 66% and 98% during dry and rainy season, respectively (confirmed by direct observation in 34% and 79%, respectively). Important reasons for low compliance during the dry season were high temperatures inside houses and problems related to changing sleeping places during the night.

Conclusion

Under programme conditions, compliance with ITN protection in young children is sufficient during the rainy season, but is rather low during the hot and dry season. Greater emphasis needs to be placed on information/education efforts to make people aware of the fact that the risk of contracting malaria may persist throughout the year.
The OnyCOE-t™ questionnaire: responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis
Authors: Potter Lori P , Mathias Susan D , Raut Monika , Kianifard Farid , Tavakkol Amir
Published: August 2006

Background

This research was conducted to confirm the validity and reliability and to assess the responsiveness and clinical meaningfulness of the OnyCOE-t™, a questionnaire specifically designed to measure patient-reported outcomes (PRO) associated with toenail onychomycosis.

Methods

504 patients with toenail onychomycosis randomized to receive 12 weeks of terbinafine 250 mg/day with or without target toenail debridement in the IRON-CLAD® trial completed the OnyCOE-t™ at baseline, weeks 6, 12, 24, and 48. The OnyCOE-t™ is composed of 6 multi-item scales and 1 single-item scale. These include a 7-item Toenail Symptom assessment, which comprises both Symptom Frequency and Symptom Bothersomeness scales; an 8-item Appearance Problems scale; a 7-item Physical Activities Problems scale; a 1-item Overall Problem scale; a 7-item Stigma scale; and a 3-item Treatment Satisfaction scale. In total, 33 toenail onychomycosis-specific items are included in the OnyCOE-t™. Clinical data, in particular the percent clearing of mycotic involvement in the target toenail, and OnyCOE-t™ responses were used to evaluate the questionnaire's reliability, validity, responsiveness, and the minimally clinical important difference (MCID).

Results

The OnyCOE-t™ was shown to be reliable and valid. Construct validity and known groups validity were acceptable. Internal consistency reliability of multi-item scales was demonstrated by Cronbach's alpha > .84. Responsiveness was good, with the Treatment Satisfaction, Symptom Frequency, Overall Problem, and Appearance Problem scales demonstrating the most responsiveness (Guyatt's statistic of 1.72, 1.31, 1.13, and 1.11, respectively). MCID was evaluated for three different clinical measures, and indicated that approximately an 8.5-point change (on a 0 to 100 scale) was clinically meaningful based on a 25% improvement in target nail clearing.

Conclusion

The OnyCOE-t™ questionnaire is a unique, toenail-specific PRO questionnaire that can be used with confidence in future studies of toenail onychomycosis. MCID was evaluated for three different clinical measures, and indicated that approximately a 7-point change (on a 0 to 100 scale) was clinically meaningful based on a 12.5% improvement in target nail clearing.
Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma
Authors: Li Jinzhong , Chen Wantao , Zhang Ping , Li Ningyi
Published: August 2006

Background

Teniposide (VM-26) has been widely used in the treatment of small cell lung cancer, malignant lymphoma, breast cancer, etc. However, there are few reports on VM-26 against oral cancers. The present study was designed to identify the effect of VM-26 against oral squamous cell carcinoma in vitro, and to provide evidence for the feasibility and effectiveness of VM-26 for application to the patients with oral cancer.

Methods

Human tongue squamous cell carcinoma cell line, Tca8113, was used. Cells were incubated with different concentrations of VM-26 for a variety of time span. Cisplatin (CDDP) was employed as a control reagent. MTT assay was used to assess the inhibitory rate of Tca8113 growth. Flow cytometer (FCM), transmission electronic microscope (TEM) and fluorescence staining were employed for determining the cell apoptotic rate. Cell cycle distribution of Tca8113 incubated with VM-26 was examined by flow cytometer assay. Statistic software (SAS 6.12, USA) was used for one-way ANOVA.

Results

The IC50 of VM-26 against Tca8113 cells was 0.35 mg/l and that of CDDP was 1.1 mg/l. The morphological changes of Tca8113 cells were observed with fluorescence microscope and TEM. Apoptotic morphological feature could be found in the nucleus. Apoptotic rate of Tca8113 cells incubated with 5.0 mg/l of VM-26 for 72 hours was 81.67% and cells waere arrested at S phase. However, when exposed to 0.15 mg/l of VM-26 for 72 hours, G2/M phase increased from 12.75% to 98.71%, while the apoptotic rate was 17.38%, which was lower than that exposed to 5.0 mg/l of VM-26.

Conclusion

VM-26 could significantly induce apoptosis of oral squamous cell carcinoma and inhibit cell growth. There may be another pathway to induce apoptosis of oral squamous cell carcinoma cells except for G2/M phase arrest.
Phase II Study of Sorafenib in Patients With Advanced Hepatocellular Carcinoma
Authors: Abou-Alfa Ghassan K. , Schwartz Lawrence , Ricci Sergio , Amadori Dino , Santoro Armando , Figer Arie , De Greve Jacques , Douillard Jean-Yves , Lathia Chetan , Schwartz Brian , Taylor Ian , Moscovici Marius , Saltz Leonard B.
Published: August 2006

Purpose

This phase II study of sorafenib, an oral multikinase inhibitor that targets Raf kinase and receptor tyrosine kinases, assessed efficacy, toxicity, pharmacokinetics, and biomarkers in advanced hepatocellular carcinoma (HCC) patients.

Methods

Patients with inoperable HCC, no prior systemic treatment, and Child–Pugh (CP) A or B, received continuous, oral sorafenib 400 mg bid in 4-week cycles. Tumor response was assessed every two cycles using modified WHO criteria. Sorafenib pharmacokinetics were measured in plasma samples. Biomarker analysis included phosphorylated extracellular signal regulated kinase (pERK) in pretreatment biopsies (immunohistochemistry) and blood-cell RNA expression patterns in selected patients.

Results

Of 137 patients treated (male, 71%; median age, 69 years), 72% had CP A, and 28% had CP B. On the basis of independent assessment, three (2.2%) patients achieved a partial response, eight (5.8%) had a minor response, and 46 (33.6%) had stable disease for at least 16 weeks. Investigator-assessed median time to progression (TTP) was 4.2 months, and median overall survival was 9.2 months. Grade 3/4 drug-related toxicities included fatigue (9.5%), diarrhea (8.0%), and hand–foot skin reaction (5.1%). There were no significant pharmacokinetic differences between CP A and B patients. Pretreatment tumor pERK levels correlated with TTP. A panel of 18 expressed genes was identified that distinguished “nonprogressors” from “progressors” with an estimated 100% accuracy.

Conclusion

Although single-agent sorafenib has modest efficacy in HCC, the manageable toxicity and mechanisms of action support a role for combination regimens with other anticancer agents.
Late Cardiac Mortality and Morbidity in Early-Stage Breast Cancer Patients After Breast-Conservation Treatment
Authors: Harris Eleanor E.R. , Correa Candace , Hwang Wei-Ting , Liao Jessica , Litt Harold I. , Ferrari Victor A. , Solin Lawrence J.
Published: August 2006

Purpose

Several studies have reported increased cardiac mortality related to the use of left-sided breast or chest-wall irradiation. This study was undertaken as a comprehensive examination of the long-term cardiac mortality and morbidity after breast irradiation using contemporary irradiation techniques.

Methods

The medical records of 961 consecutive patients presenting between 1977 and 1994 with stage I or II breast cancer treated with breast conservation treatment were reviewed. Data was recorded on baseline pretreatment patient, tumor and treatment characteristics and on subsequent cancer or cardiac related events. The median follow-up time was 12 years.

Results

There was no difference in overall mortality from any cardiac cause (P = .25). Death from any cardiac cause occurred in 2% of right-sided patients and 3.5% of left-sided patients. However, in the second decade after treatment, there was a higher rate of cardiac deaths in left-sided patients, with a cumulative risk of 6.4% (95% CI, 3.5% to 11.5%) for left-sided compared with 3.6% (95% CI, 1.8% to 7.2%) for right-sided patients at 20 years. There were statistically higher rates of chest pain, coronary artery disease, and myocardial infarction diagnosed in left-sided patients (all P ≤ .002). The presence of hypertension was associated with a higher risk of coronary artery disease in left-sided patients.

Conclusion

Irradiation to the left breast is not associated with a higher risk of cardiac death up to 20 years after treatment, but is associated with an increased rate of diagnoses of coronary artery disease and myocardial infarction compared with right breast treatment.
Therapy of Parapneumonic Effusions in Children: Video-Assisted Thoracoscopic Surgery Versus Conventional Thoracostomy Drainage
Authors: Kurt Beth A. , Winterhalter Kimberly M. , Connors Robert H. , Betz Bradford W. , Winters John W.
Published: August 2006

OBJECTIVE. Controversy surrounds the optimal treatment of parapneumonic effusions. This trial of pediatric patients with community-acquired pneumonia and associated parapneumonic processes compared primary video-assisted thoracoscopic surgery with conventional thoracostomy drainage.

DESIGN. A prospective, randomized trial was conducted at DeVos Children's Hospital (Grand Rapids, MI) between November 2003 and May 2005. All of the patients under 18 years of age with large parapneumonic effusions were approached for enrollment in the study. After enrollment, each patient was randomly assigned to receive either video-assisted thoracoscopic surgery or thoracostomy tube drainage of the effusion. Subsequent therapies (fibrinolysis, imaging, and further drainage procedures) were similar for each group per protocol.

RESULTS. Eighteen patients were enrolled in the study: 10 in video-assisted thoracoscopic surgery and 8 in conventional thoracostomy. The groups were demographically similar. No mortalities were encountered in either group, and everyone was discharged from the hospital with acceptable outcomes. Yet, there were multiple variables that demonstrated statistical difference. Hospital length of stay, number of chest tube days, narcotic use, number of radiographic procedures, and interventional procedures were all less in the patients who underwent primary video-assisted thoracoscopic surgery. In addition, no patient in the video-assisted thoracoscopic surgery group required fibrinolytic therapy, which was also statistically different from the thoracostomy drainage group.

CONCLUSIONS. The outcomes of this study strongly suggest that primary video-assisted thoracoscopic surgery for evacuation of parapneumonic effusions is superior to conventional thoracostomy drainage.
Networks, Agent-Based Models and the Antonine Itineraries
Authors: Graham Shawn
Published: August 2006

This paper presents a way of looking at Roman space from a Roman perspective, and suggests ways in which this point of view might open up new approaches in Roman archaeology. It turns on one conception of Roman space in particular, preserved for us in the Antonine Itineraries. Working from a position that considers the context of the itineraries as movement-through-space, this paper presents an investigation using social network analysis and agent-based simulation to re-animate the itineraries. The itineraries for Iberia, Gaul, Italy, and Britain are considered. The results of the social network analysis suggest structural differences in the way that the itineraries presented space to the reader/traveler. The results of the simulation of information diffusion through these regions following the routes in the itineraries suggest ways that this conception of space affected the cultural and material development of these regions. Suggestions for extending the basic model for more complicated archaeological analyses are presented.
Teaching a Distance Education Version of the Technical Communication Service Course: Timesaving Strategies
Authors: Battalio John T.
Published: August 2006

The author has taught a distance education version of the undergraduate technical communication service course at Boise State University since 1997 and shares the strategies he has found to decrease the time instructors spend teaching online, thereby enabling them to use the time they do have to enhance their students' online experience. These strategies are distributed among four areas: management of collaboration, presentation of course material, grading, and interaction with students. For each one, the author presents the problems that may occur and approaches to resolving them. The article addresses a number of concerns expressed in the scholarly literature on distance education and is informed by surveys given to five sections of the author's course taught between 2001 and 2003. Interspersed through the article is an overview of some of the current research and commentary on distance education of particular interest to those teaching the technical communication service course via the Internet.
Disease prevalence among dogs and cats in the United States and Australia and proportions of dogs and cats that receive therapeutic diets or dietary supplements
Authors: Freeman Lisa M. , Abood Sarah K. , Fascetti Andrea J. , Fleeman Linda M. , Michel Kathryn E. , Laflamme Dorothy P. , Bauer Cassandra , Kemp Brona L. E. , Van Doren Janine R. , Willoughby Kristina N.
Published: August 2006

Objective—To estimate disease prevalence among dogs and cats in the United States and Australia and proportions of dogs and cats that receive therapeutic diets or dietary supplements.

Design—Telephone survey.

Sample Population—Dog and cat owners located in 5 geographic areas.

Procedures—A telephone survey was administered to dog and cat owners.

Results—Of 18,194 telephone calls that were made, 1,104 (6%) were to individuals who owned at least 1 dog or cat and agreed to participate. Information was collected for 635 dogs and 469 cats. Only 14 (1%) respondents indicated that their pet was unhealthy, but 176 (16%) indicated that their pets had 1 or more diseases. The most common diseases were musculo-skeletal, dental, and gastrointestinal tract or hepatic disease. Many owners (n = 356) reported their pets were overweight or obese, but only 3 reported obesity as a health problem in their pets. Owners of 28 (2.5%) animals reported that they were feeding a therapeutic diet, with the most common being diets for animals with renal disease (n = 5), reduced-calorie diets (5), and reduced-fat diets (4). Owners of 107 of 1,076 (9.9%) animals reported administering dietary supplements to their pets. Multivitamins (n = 53 animals), chondroprotective agents (22), and fatty acids (13) were the most common dietary supplements used.

Conclusions and Clinical Relevance—Results suggest that most dogs and cats reported by their owners to have a health problem were not being fed a therapeutic diet. In addition, the rate of dietary supplement use was lower than that reported for people.
Disorders of the infraspinatus tendon and bursa in three horses
Authors: Whitcomb Mary Beth , le Jeune Sarah S. , MacDonald Melinda M. , Galuppo Larry D. , Judy Carter E.
Published: August 2006

Case Description—3 horses with penetrating wounds to the shoulder area were examined because of forelimb lameness.

Clinical Findings—All horses had physical examination findings (decreased cranial phase of the stride, swelling in the shoulder region, and signs of pain on manipulation of the shoulder) that were suggestive of problems in the upper portion of the forelimb. Injury to the biceps tendon or bursa was the primary differential diagnosis in each instance, but no abnormalities involving those structures were found. Radiographic and ultrasonographic imaging revealed injuries to the caudal eminence of the greater tubercle of the humerus, the infraspinatus tendon, and the infraspinatus bursa. Examination with ultrasound was more sensitive than radiography at detecting both osseous and soft tissue changes.

Treatment and Outcome—All 3 horses responded favorably to treatment with antimicrobials and non-steroidal anti-inflammatory drugs. Although initial response to standing lavage was favorable in 1 horse, endoscopic lavage was later required. Standing removal of fracture fragments was performed in 2 horses. Ultrasonographic imaging was helpful in monitoring the response to treatment and changes in the affected structures. All 3 horses eventually became sound after treatment.

Clinical Relevance—Infraspinatus bursitis and tendonitis should be included in the differential diagnoses of horses with shoulder lameness. Diagnosis and monitoring should include ultrasonographic monitoring. The prognosis for return to soundness after appropriate treatment appears to be good.
Acquired cervical scoliosis attributed to Parelaphostrongylus tenuis infection in an alpaca
Authors: Johnson Amy L. , Lamm Catherine G. , Divers Thomas J.
Published: August 2006

Case Description—A 2-year-old alpaca was evaluated because of acute onset of cervical scoliosis.

Clinical Findings—Physical examination revealed severe scoliosis of the caudal portion of the cervical vertebral column with a C-shaped curvature to the right side. No gait deficits were observed. Cervical radiography confirmed severe curvature of C4 to C6 but did not reveal any bony changes. Cerebrospinal fluid had high total protein concentration and extremely high nucleated cell count with a high proportion of eosinophils, suggesting parasitic infection.

Treatment and Outcome—The alpaca was treated for suspected parelaphostrongylosis with ivermectin, fenbendazole, flunixin, vitamin E, thiamine, physical therapy, and a custom-made neck brace. The alpaca's condition continued to deteriorate, and it developed tetraparesis and ataxia and was euthanized after approximately 1 month. Microscopic evaluation of the cervical spinal cord revealed marked vacuolar changes in the left medial portion of the ventral funiculus, mild lymphoplasmacytic infiltration, and multifocal granulomas. The lesions were continuous from C1 to C7 and were compatible with parasite migration.

Clinical Relevance—To the authors' knowledge, this is the first report of acquired scoliosis in an alpaca, which appears to represent an unusual manifestation of parelaphostrongylosis that was reported in horses.
Luminescence of Functionalized Carbon Nanotubes as a Tool to Monitor Bundle Formation and Dissociation in Water: The Effect of Plasmid‐DNA Complexation
Authors: Lacerda L. , Pastorin G. , Wu W. , Prato M. , Bianco A. , Kostarelos K.
Published: August 2006

Functionalized carbon nanotubes (f‐CNTs) are explored as novel nanomaterials for biomedical applications. UV‐vis luminescence of aqueous dispersions of CNT–NH3+ and CNT–NH–Ac (NH–Ac: acetamido) is observed using standard laboratory spectrophotometric instrumentation, and the measured fluorescence intensity is correlated with the aggregation state of the f‐CNTs: a high intensity indicates improved f‐CNT individualization and dispersion, while a decrease in fluorescence intensity indicates a higher degree of nanotube aggregation and bundling as a result of varying the sodium dodecyl sulfate (SDS) concentrations and pH in the aqueous phase. Moreover, utilization of this relationship between fluorescence intensity and the state of f‐CNT aggregation is carried out to elucidate the interactions between f‐CNTs and gene‐encoding plasmid DNA (pDNA). pDNA is shown to interact with CNT–NH3+ primarily through electrostatic interactions that lead concomitantly to a higher degree of f‐CNT bundling. The CNT–NH3+/pDNA interactions are successfully competed by SDS/f‐CNT surface interactions, resulting in the displacement of pDNA. These studies provide exemplification of the use of fluorescence spectrophotometry to accurately describe the aggregation state of water‐soluble f‐CNTs. Characterization of the complexes between pDNA and f‐CNTs elucidates the opportunities and limitations of such supramolecular systems as potential vectors for gene transfer.
High‐Quality Photonic Crystals Infiltrated with Quantum Dots
Authors: Paquet C. , Yoshino F. , Levina L. , Gourevich I. , Sargent E. H. , Kumacheva E.
Published: August 2006

We report a method for producing colloidal crystals heavily loaded with PbS quantum dots (QDs). The approach employed uses capillary forces to load the QDs in the interstitial voids of the colloid crystals and yields highly ordered structures with a high loading of QDs. The infiltration process is qualitatively monitored using confocal fluorescence microscopy and scanning electron microscopy. The optical properties of the resulting composite structure are examined using optical spectroscopy. The shift in the stopband resulting from the infiltration of the colloid crystal shows that the PbS QDs occupy nearly 100 % of the volume of the interstitial space.
Free radical polymerization of methyl methacrylate initiated by the diphosphine Mo(0) complexes
Authors: Menteş Ayfer , Hanhan Murat Emre , Hazer Baki
Published: August 2006

The polymerization of methyl methacrylate MMA catalyzed by [Mo(CO)4L2] [L2 = diphenylphosphinomethane (dppm), diphenylphosphinoethane (dppe) or diphenylphosphinopropane (dppp)] has been studied. The activity of these single‐component catalysts depends on the length of the (CH2)n bridge of diphosphine ligand. Thus, the dppm derivative displays higher activity than dppe or dppp ligands. These complexes, as free radical initiators, afforded the methyl methacrylate polymerization in chlorinated solvents. The mechanism of the polymerization was discussed and a radical mechanism was proposed. Copyright © 2006 John Wiley & Sons, Ltd.
Metal‐based isatin‐bearing sulfonamides: their synthesis, characterization and biological properties
Authors: Chohan Zahid H. , Shaikh Ali U. , Naseer Muhammad M.
Published: August 2006

A new series of antibacterial and antifungal isatin bearing sulfonamides and their cobalt (II), copper (II), nickel (II) and zinc (II) metal complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against Bacillus cereus, Corynebacterium diphtheriae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Shigilla dysentriae and Staphylococcus aureus and for in vitro antifungal activity against Trichophyton schoenleinii, Candid glabrata, Pseudallescheria boydii, Candida albicans, Aspergillus niger, Microsporum canis and Trichophyton mentagrophytes. The results of these studies revealed that all compounds showed moderate to significant antibacterial activity. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties. Only three compounds, 2, 11 and 22 displayed potent cytotoxic activity as LD50 = 1.56 × 10−7, 1.59 × 10−7 and 1.67 × 10−7 M/ml respectively, against Artemia salina. Copyright © 2006 John Wiley & Sons, Ltd.
NHC–Pd(II) complex–Cu(I) co‐catalyzed homocoupling reaction of terminal alkynes
Authors: Shi Min , Qian Heng‐xin
Published: August 2006

Two NHC–Pd(II) complexes synthesized from trans‐cyclohexane‐1,2‐diamine were fairly effective in the NHC–Pd(II) complex/Cu co‐catalyzed terminal alkyne homocoupling reaction to give the corresponding symmetrical 1,4‐disubstituted 1,3‐diynes in good yields under mild conditions. Copyright © 2006 John Wiley & Sons, Ltd.
Sandwich Complexes Based on the “All‐Metal” Al42‐ Aromatic Ring.
Authors: Mercero Jose M. , Formoso Elena , Matxain Jon M. , Eriksson Leif A. , Ugalde Jesus M.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure and Stability of (HBNH)n Clusters.
Authors: Wang Hong , Wu Hai‐Shun , Jia Jian‐Feng
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structures and Hydrogen‐Induced Decomposition of La(Mg1‐xAlx)3 Alloys.
Authors: Zhang Q. A. , Liu Y. J. , Si T. Z.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural Study on a New Cs2S2(SO4)3 Crystal.
Authors: Fukami T. , Chen R. H.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polymorphism of CaAl2O4 — Structural Investigations of Two High Pressure Modifications.
Authors: Lazic B. , Kahlenberg V. , Konzett J. , Kaindl R.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
X‐Ray Single Crystal Structures of Cd(AuF6)2, Mg(HF)AuF4AuF6 and KAuF6 and Vibrational Spectra of Cd(AuF6)2 and KAuF6.
Authors: Mazej Zoran , Goreshnik Evgeny
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure and Magnetic Properties of EuNi7+xIn6‐x.
Authors: Zaremba Vasyl' I. , Kaczorowski Dariusz , Muts Ihor R. , Hoffmann Rolf‐Dieter , Heying Birgit , Poettgen Rainer
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
catena‐Poly[bis(tert‐butylammonium)[plumbate(II)‐tri‐μ‐iodo] iodide dihydrate].
Authors: Billing David G. , Lemmerer A.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Luminescence Properties of Red‐Emitting M2Si5N8:Eu2+ (M: Ca, Sr, Ba) LED Conversion Phosphors.
Authors: Li Y. Q. , van Steen J. E. J. , van Krevel J. W. H. , Botty G. , Delsing A. C. A. , DiSalvo F. J. , de With G. , Hintzen H. T.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Evidence of the Formation of a New Rock‐Salt Type Compound Li2MgTiO4 and of Its Role on the Properties of the Li Doped MgTiO3.
Authors: Bernard J. , Houivet D. , Hervieu M. , Haussonne J. M.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Partial Phase Diagram of the Au—Ag—Zr Ternary System
Authors: Zhang Kanghou , Li Jinhong
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regenerative Adsorption and Removal of H2S from Hot Fuel Gas Streams by Rare Earth Oxides.
Authors: Flytzani‐Stephanopoulos Maria , Sakbodin Mann , Wang Zheng
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Some Experimental Evidence that Zn4O(BO3)2 Is Zn6O(OH)(BO3)3.
Authors: Delahaye Thibaud , Boucher Florent , Paris Michael , Joubert Olivier , Caldes Mayte , Piffard Yves
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Flux Crystal Growth, Structure and Properties of the New Rare‐Earth Compounds EuAl4‐xSi4 (x≈1), TmAlSi and LuAlSi.
Authors: Tobash Paul H. , Bobev Svilen
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Self‐Sacrificing Template Route to Spinel MIIIn2S4 (MII: Mn, Zn, Cd, Fe, Co, Ni) and MIIn5S8 (MI: Cu, Ag) Porous Microspheres.
Authors: Lei Shuijin , Tang Kaibin , Qi Yunxia , Fang Zhen , Zheng Huagui
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Characterization of Ternary NH4Ln2F7 (Ln: Y, Ho, Er, Tm, Yb, Lu) Nanocages.
Authors: Liang Xin , Wang Xun , Wang Leyu , Yan Rouxue , Peng Qing , Li Yadong
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural Investigations of Two New Ternary Magnesium—Niobium Hydrides, Mg6.5NbH≈14 and MgNb2H≈4.
Authors: Sato Toyoto , Kyoi Daisuke , Roennebro Ewa , Kitamura Naoyuki , Sakai Tetsuo , Noreus Dag
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Mo(V) Monophosphate with Bromine and Mixed Valent Lead and a Pb=O Double Bond: Pb2+(Pb4+O)Br(Mo5+O)2 (PO4)3.
Authors: Leclaire Andre
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Crystal Structures of Four New Bromo‐Chalcogenides: MnSbS2Br, MnBiSe2Br and Two Allotropic Forms of MnSbSe2Br. Crystal Chemistry of the MnPnQ2X Family (Pn: Sb, Bi; Q: S, Se; X: Cl, Br, I).
Authors: Doussier Charlotte , Moelo Yves , Leone Philippe
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrothermal Synthesis, Crystal Structure, and Vibrational and Moessbauer Spectra of a New Tricationic Orthophosphate — KCo3Fe(PO4)3.
Authors: Assaaoudi Hassane , Fang Zhen , Ryan Dominic H. , Butler Ian S. , Kozinski Janusz A.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gold‐Catalyzed Heterocycle Synthesis Using Homopropargylic Ethers as Latent Electrophiles.
Authors: Jung Hyung Hoon , Floreancig Paul E.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rhodium‐Catalyzed Tandem Vinylcyclopropanation of Strained Alkenes.
Authors: Tseng Nai‐Wen , Mancuso John , Lautens Mark
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The OsO4‐Mediated Oxidative Cleavage of Olefins Catalyzed by Alternative Osmium Sources.
Authors: Whitehead Daniel C. , Travis Benjamin R. , Borhan Babak
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selenoxides as Catalysts for Epoxidation and Baeyer—Villiger Oxidation with Hydrogen Peroxide.
Authors: Goodman Margaret A. , Detty Michael R.
Published: August 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.