bluuebunny/crossref_metadata_2025 huggingface dataset:
Tralokinumab Improves Signs and Symptoms of Moderate-to-Severe Atopic Dermatitis in Patients Aged 12 years and Older With and Without Atopic Comorbidities
Authors: Paller Amy , Soong Weily , Boguniewicz Mark , Geng Bob , Thyssen Jacob , Rosso Aldana , Steffensen Louise , Schneider Shannon , Wollenberg Andreas
Published: January 2024

Background: Atopic dermatitis (AD) is an inflammatory skin disease associated with atopic comorbidities, including asthma, food allergy, hay fever, and allergic conjunctivitis. Tralokinumab, a high-affinity monoclonal antibody that specifically targets IL-13, is indicated for the treatment of moderate-to-severe AD. We assessed the impact of atopic comorbidities on the efficacy and safety of tralokinumab vs. placebo for moderate-to-severe AD in patients age ≥12 years.

Methods: This post-hoc analysis presents data from the adult trials ECZTRA 1 and 2 (NCT03131648 and NCT03160885 pooled; 300 mg tralokinumab every 2 weeks [Q2W] vs. placebo) and ECZTRA 3 (NCT03363854; 300 mg tralokinumab Q2W vs. placebo, both plus TCS as needed), and the ECZTRA 6 adolescent trial (NCT03526861; pooled 150 mg and 300 mg tralokinumab Q2W vs. placebo). Tralokinumab-treated patients received a loading dose. Proportion of patients achieving IGA 0/1 and EASI-75 at Week 16 according to patient-reported current or past atopic comorbidity are presented as observed regardless of rescue medication use; missing data were imputed as non-responders. 

Results: In total 2,223 patients were included across four trials. Among patients in ECZTRA 1 and 2, 50.5% reported history of asthma, 38.5% food allergy, 53.8% hay fever, and 33.5% allergic conjunctivitis, while 19.8% reported no atopic comorbidities and 79.3% reported ≥1 atopic comorbidity. Proportions of patients in ECZTRA 3 and 6 reporting history of atopic comorbidities were largely similar, although more adolescent patients reported food allergy. In all subgroups at Week 16, higher proportions of patients receiving tralokinumab vs. placebo achieved EASI-75. In ECZTRA 1 and 2, response rates among patients in each subgroup were asthma: 35.3% vs. 12.8%, food allergy: 33.2% vs. 14.7%, hay fever: 36.8% vs. 16.5%, allergic conjunctivitis: 34.8% vs. 12.7%, none: 34.6% vs. 20.5%; and ≥1 atopic comorbidity: 35.5% vs. 15.2% (P<0.05 for all). A similar pattern of response was observed in ECZTRA 3 and 6, and for IGA 0/1 across trials. EASI-75 response rates for tralokinumab-treated patients were consistent across patients with different numbers of atopic comorbidities. Safety across subgroups was consistent with the safety profile of tralokinumab observed overall in adults and adolescents.

Conclusions: 16 weeks of tralokinumab treatment improved AD signs and symptoms in adult and adolescent patients with and without atopic comorbidities, regardless of type or number of atopic comorbidities. The safety profile of tralokinumab was consistent between patients with and without atopic comorbidities.
Neutralizing Interleukin-13 with Tralokinumab Reduces Abundance of S. aureus in Adolescents with Atopic Dermatitis
Authors: Beck Lisa , Weidinger Stephan , Tauber Marie , Saeki Hidehisa , Irvine Alan , Eichenfield Lawrence , Werfel Thomas , Arlert Petra , Kurbasic Azra , Røpke Mads , Paller Amy
Published: January 2024

Patients with atopic dermatitis (AD) are frequently colonized with high levels of S. aureus. Dysregulation of the skin microbiome in AD is influenced by epidermal barrier disruption and type 2 inflammation. Tralokinumab is a high-affinity, monoclonal antibody that targets IL-13, a key driver of type 2 inflammation. We assessed S. aureus abundance in lesional and non-lesional skin and evaluated the effects of tralokinumab on S. aureus abundance in adolescents with moderate-to-severe AD (ECZTRA 6, NCT03526861). 301 adolescents (aged 12-17 years) were randomized to receive tralokinumab 150mg or 300mg SQ every 2 weeks, or placebo. Skin swabs collected from lesional and non-lesional skin at baseline and Week 16 were assessed for S. aureus abundance by femA qPCR. Differences in percentage of S. aureus+ (SA+; defined as >1.07 gene copies/cm2) patients among the groups were assessed using a logistic regression model adjusting for baseline SA status and rescue use (any TCI, TCS, or systemic treatment). From baseline to Week 16, the percentage of patients with SA+ lesional skin was reduced from 83.5% to 41.0% with tralokinumab 150 mg and from 84.3% to 41.9% with tralokinumab 300 mg compared to 85.2% to 78.3% with placebo (difference vs placebo 150mg/300mg: -41.0/-39.6; P<0.001). The percentage of patients with SA+ non-lesional skin was reduced from 78.7% to 34.6% with tralokinumab 150 mg and from 72.2% to 42.4% with tralokinumab 300 mg compared to 74.4% to 68.8% with placebo (difference vs placebo 150mg/300mg: -37.0/-26.1; P≤0.001) from baseline to Week 16. These data support the targeting of IL-13 in improving AD-associated dysbiosis in adolescents.
Incorporating the 40-Gene Expression Profile (40-GEP) Test within Each Clinicopathologic Staging System Improves Metastatic Risk-Stratification in Patients Diagnosed with Cutaneous Squamous Cell Carcinoma (cSCC) and One or More High Risk Factors
Authors: Wysong Ashley , Somani Ally‐Khan , Ibrahim Sherrif , Cañueto Javier , Fitzgerald Alison , Siegel Jennifer , Prasai Anesh , Goldberg Matthew , Farberg Aaron , Kasprzak Julia , Brodland David , Koyfman Shlomo , Arron Sarah
Published: January 2024

Purpose: Three clinicopathologic-based risk assessment systems (Brigham and Women’s Hospital (BWH) staging, American Joint Committee on Cancer 8th Edition (AJCC8) staging or National Comprehensive Cancer Network (NCCN)) are used to guide treatment pathway decisions, including nodal assessment and adjuvant radiation therapy. Each of these systems suffers from accuracy limitations. The 40-GEP test was developed to use tumor biology to predict regional/distant metastasis and has previously been validated as an independent risk stratification test for cSCC patients who are diagnosed with one or more clinicopathologic risk factors. The purpose of this study was to evaluate the performance of the 40-GEP test in the prognostication of metastasis when results are used in the context of each of the clinicopathologic risk assessment system.
Study: Under an IRB-approved protocol, centralized pathology review, and sample analysis were performed in a CAP-accredited, CLIA-certified laboratory using formalin-fixed paraffin-embedded archival primary SCC tumor specimens with one or more risk factors (n=897).  Verified clinicopathologic information and outcomes data were collected from 58 contributing centers. Three-year risk stratification for regional and distant metastasis was assessed using Kaplan-Meier analysis for metastasis-free survival (MFS) for Class 1 (low risk), Class 2A (moderate risk), and Class 2B (high risk) groups. Nested Cox regression models and accuracy metrics were used to compare risk prediction of clinicopathologic risk assessment vs. clinicopathologic risk assessment in combination with 40-GEP.
Results: The overall cohort had a metastasis rate of 13.2%, substantiating the high-risk status of this population. For the overall cohort, the 40-GEP test showed clinically and statistically significant differences in MFS rates between Class 1 (94.1%), Class 2A (81.1%), and Class 2B (56.8%) (p<0.001, log-rank). Combining the results of the 40-GEP test with staging systems or NCCN risk categories led to increases in both NPV and PPV, indicating that a 40-GEP result improves the prediction of metastatic risk over the use of staging alone Table 1. Inclusion of 40-GEP with different clinicopathologic risk assessment methods (BWH and AJCC8, or NCCN risk subgroups) yielded significant improvements in prediction of metastatic events compared to each risk assessment method that did not include 40-GEP (ANOVA for deviance, p<0.0001 for each comparison).
Conclusions: Incorporating the 40-gene expression profile (40-GEP) test within each clinicopathologic risk assessment system improves risk-stratification, enabling more accurate treatment pathway decisions.
Safety and Tolerability of Fixed-Dose Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel in Black Participants With Acne
Authors: Callender Valerie , Cook-Bolden Fran , Kircik Leon , Weiss Jonathan , Alexis Andrew , Gold Michael , Tanghetti Emil , Baldwin Hilary , Stein Gold Linda , Sugarman Jeffrey
Published: January 2024

Background: As acne can cause inflammation-associated sequelae (eg, post-inflammatory hyperpigmentation) in individuals with melanin-rich skin, effective and rapid management must be balanced with minimization of skin irritation. Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (IDP-126) polymeric mesh gel is the first fixed-dose, triple-combination topical acne product in development. In clinical studies, over half of participants achieved treatment success with IDP-126 gel after 12 weeks. The objective of this pooled, post hoc analysis was to evaluate safety and tolerability of IDP-126 gel in Black participants.

Methods: In two identical phase 3, double-blind, randomized, 12-week studies (NCT04214639; NCT04214652), participants aged ≥9 years with moderate-to-severe acne were randomized (2:1) to receive once-daily IDP-126 or vehicle gel. Assessments included treatment-emergent adverse events (TEAEs) and cutaneous safety/tolerability (hyperpigmentation, hypopigmentation, erythema, scaling, itching, burning, and stinging; graded from 0 [none] to 3 [severe]). Post hoc analyses were based on participants’ self-identification of race as ‘Black or African American’ (hereafter referred to as Black).

Results: Of 363 randomized participants, 54 (14.9%) self-identified as Black. No serious TEAEs were reported and no TEAEs led to discontinuation. Treatment-related TEAEs were reported in 7 (17.5%) IDP-126-treated Black participants; the most common were application site pain (n=5 [12.5%]) and application site pruritus (n=2 [5.0%]). No vehicle-treated participants reported treatment-related TEAEs. TEAEs in Black participants were generally similar to the overall population.

Mean severity scores for all cutaneous safety/tolerability assessments following IDP-126 treatment were <0.55 at all study visits (1=mild). Rates of hyperpigmentation remained relatively unchanged throughout the study while erythema decreased by over 10% from baseline to week 12 with IDP-126 treatment. Rates of all other cutaneous safety/tolerability assessments were low (<9%) at both baseline and week 12.

Conclusions: Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (IDP-126) gel was safe and well tolerated in Black participants with moderate-to-severe acne over 12 weeks, with no discontinuations or serious TEAEs. Additionally, IDP-126 treatment led to improved erythema in Black participants and no substantial increases in hyperpigmentation. These post hoc analyses add valuable information to the limited literature describing treatment effects and tolerability of novel acne therapeutics in Black individuals.

Support: Ortho Dermatologics.
Topical Clindamycin For Acne Vulgaris: Pharmacovigilance Safety Review and Retrospective Analysis of Gastrointestinal Events
Authors: Pelet del Toro Natalia , Strunk Andrew , Wu Jashin , Stein Gold Linda , Del Rosso James , Brodell Robert , Han George
Published: January 2024

Background: Clindamycin, a lincosamide antibiotic, was the 125th most prescribed medicine in the US in 2020. Topical formulations that combine clindamycin with benzoyl peroxide or a retinoid are commonly used for acne vulgaris (AV) treatment. While oral and topical clindamycin carry warnings/contraindications regarding the development of gastrointestinal (GI) adverse events (AEs), the real-world incidence of these AEs with topical clindamycin is unknown. The objective is to provide an overview of safety data for topical clindamycin when used for AV treatment.

Methods: Safety data from published literature on PubMed® (case reports, clinical trials data, retrospective data), previously unpublished worldwide pharmacovigilance data (from January 1, 1900-December 31, 2022), and two unpublished retrospective cohort studies of US electronic medical records (EMR; January 1, 2011 to January 31, 2019) were reviewed, with a focus on inflammatory bowel disease (IBD) and GI AEs following topical clindamycin monotherapy or combination treatment

Results: There have been only 4 published case reports of topical clindamycin-associated GI AEs, which were all published between the years 1981-1997. In 8 published pivotal phase 3 clinical trials of topical clindamycin monotherapy or combination treatment for AV, GI-related AEs were reported in 1.4% of clindamycin-treated participants (38/2,672; safety populations). According to the pharmacovigilance data, the rate of GI-related adverse drug reactions with topical clindamycin-containing products was 0.000045% (64/141,084,533). In 1 published retrospective report, there were 0 reports of colitis from the 1,124 patients estimated to have received topical clindamycin prescriptions in the years 1977-1980. In the first retrospective EMR study, results indicate that physicians prescribe topical clindamycin for AV treatment equally to patients with a history of IBD (19.0%; 98/515) or without (20.7%; 14,495/70,151). The second retrospective EMR study showed that among patients with AV and an initial prescription for topical clindamycin (monotherapy or combination; n=18,012), there were 3 (0.02%) incident cases of pseudomembranous colitis within 30 days; none of these cases had a history of IBD.

Conclusions: A review of published case reports, clinical trials safety data, worldwide pharmacovigilance data, and retrospective US prescription data demonstrate that GI events—including colitis or pseudomembranous colitis—in patients exposed to topical clindamycin is extremely low, regardless of IBD history.

Support: Ortho Dermatologics
INVESTIGATION OF THE IMPACT OF DIFFERENT PARAMETERS ON THE MORPHOLOGY OF ELECTROSPUN POLYURETHANE NANOFIBERS
Authors: Sabri Fatima T. , Mahammed Manaf  A.
Published: January 2024

In this research, nonwoven nanofiber mats were prepared using the electrospinning method for the solution of polyurethane polymer dissolved in acetic acid. Effects of solution concentration, solution flow rate, as well as high voltage on the morphonology and wettability of the prepared nanofibers were studied. Nanofiber morphology was investigated through the analysis of scanning electron microscopy (SEM) micrographs using ImageJ software, while the wettability of the nanofiber mat surfaces was studied through the measurement of the contact angle. Results revealed that when the concentration of the solution was changed from 8wt% to 12wt%, the average nanofiber diameter showed a significant increase from 0.326 µm to 0.380 µm, while the contact angle increased from 39 degrees to 79 degrees. Results also showed that when the applied high voltage was changed from 10 KV to 25 KV, the average nanofiber diameter decreased and then increased within the range of 0.380 to 0.497 µm and that the contact angle was increased from 81 degrees to 108 degrees showing an obvious switching from hydrophilic towards hydrophobic surface. When the syringe pump flow rate was changed from 0.012 ml/min to 0.02 ml/min, morphology measurements showed that the average nanofiber diameter showed a significant increase from 0.351 µm to 0.456 µm, and the surface contact angle was also increased from 43 degrees to 98 degrees. Finally, the results of Fourier Transform Infrared Spectroscopy (FTIR) and X-ray diffraction analysis (XRD) tests showed that the electrospun polyurethane polymer material used in this work was not changed during the electrospinning process.
An analysis of diabetic macular edema anti-vegf treatment effectiveness in avitreal eyes
Authors:   The Khabarovsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Pomytkina N.V. ,   Far Eastern State Medical University, Khabarovsk, Lebedev Y.B. ,   The Khabarovsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Sorokin E.L. ,   The Khabarovsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk,   Far Eastern State Medical University, Khabarovsk, Pashentsev Y.E. ,   The Khabarovsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk
Published: January 2024

Aim. To analyze the clinical efficacy of anti-VEGF therapy for diabetic macular edema (DME) in avitreal eyes. Methods. 34 patients (38 eyes) with vitreous loss and DME on the background of preproliferative diabetic retinopathy (PPDR) (18 eyes) and proliferative diabetic retinopathy (PDR) (20 eyes) were examined in the main study group. The comparison group consisted of 40 patients (40 eyes) with native vitreous body and DME on the background of PPDR (20 eyes) and PDR (20 eyes). Intravitreal injections of Lucentis 0.5 mg (IVIL) were carried out according to «three monthly injections» scheme, then – to «on demand» scheme. Results. Complete regression of DME in avitreal eyes occurred in 74 % of cases; in eyes with native vitreous body – in 75 %. The duration of postoperative reaction in eyes with vitreous loss was up to 10–14 days, compared with 1–3 days in eyes with native vitreous body. The results of the study revealed that number of IVIL was significantly less in patients with DME on the background of PPDR than PDR. Conclusion. Presence of local neuroepithelial detachment on the background of diffuse DME is prognostically favorable factor for anti-VEGF therapy. The effectiveness of IVIL in DME treatment is comparable in eyes with native vitreous body and avitreal eyes. Key words: diabetes mellitus; diabetic macular edema; preproliferative diabetic retinopathy; proliferative diabetic retinopathy; avitria; Lucentis intravitreal injections.
Afectarea coronariană în sindromul pediatric inflamator multisistemic asociat SARS-CoV-2
Authors: Luca Ioana , Andone Diana-Elena , Arbanaş Ioana
Published: January 2024

Introduction. SARS-CoV-2 associated multi-systemic in­flam­mation syndrome represents a pathology with diverse symp­to­ma­to­logy, the pediatric population in question de­ve­­lo­ping fever for longer than three days, with high in­­flam­­ma­­tory markers values, and being susceptible to gas­­tro­­in­tes­ti­nal, cutaneous and mucosal tissue, cardiac or res­­pi­­ra­tory manifestations. The objective of this paper is to high­light the importance of dosing inflammatory car­diac mar­kers (NT-proBNP, CK-MB) and of performing an echo­car­dio­gra­phic examination when evaluating a patient with post-COVID-19 inflammatory status, and to point out the main treatment recommendations in Eu­ro­pean or American guides. Discussion. The medical li­tera­ture de­scribes cases of coronary artery dilation in teen­agers, but it is more often seen in school-age children. The treatment in the men­tioned stu­dies consists primarily of aspirin, cor­ti­sone and intra­venous immunoglobulin, and in some cases, anti­bio­tics were of­fered. Conclusions. When con­fronted with a patient who is at a high risk of deve­lo­ping or ex­pe­rien­cing multisystem in­flam­ma­tory syndrome as­so­cia­ted with SARS-CoV-2, it is im­pe­ra­tive to evaluate the car­diac func­tion, with laboratory and imaging tests.
Arc aortic întrerupt asociat cu alte malformaţii cardiace congenitale
Authors: Luca Alina-Costina , Diaconescu Cosmin , Stoica Cristina , Stana Bogdan A.
Published: January 2024

The interrupted aortic arch is a rare congenital mal­for­ma­tion (about 1.5% of cardiac malformations) with several anatomical variants and is often associated with other con­ge­nital cardiac anomalies. The authors present the case of a pediatric patient with aortic arch interruption and other congenital heart defects, along with the diagnostic features and indications for treatment.
SOUČASNÉ A BUDOUCÍ PROJEKTY JEDNOPODLAŽNÍCH JEDNOTEK Z RODINY PANTERŮ
Authors:   VTS pri Žilinskej univerzite v Žiline, Černušek Petr , Škvaridlo Richard
Published: January 2024

Píše se rok 2012 a ve Škodě Transportation v Plzni se křtí první jednopodlažní jednotka pojmenovaná jménem RegioPanter. Vzniká tak produkt, který je novou generací jednopodlažních jednotek v České republice. Kdy ty současné (ř. 560, 460, 451) dosluhují nebo dosloužily, a cestovní komfort nedosahuje potřeb dnešního cestujícího. Společnost Škoda Transportation se spolu s dceřinou společností Škoda Vagonka vrací znovu k výrobě jednopodlažních jednotek po cca 40 letech. Specifikum oproti předchozím produktům stejného typu je rozhodně hliníková hrubá stavba každého z vozů, která se vyrábí na specializovaném pracovišti v Ostravě. V současné době se tento typ vozidla vyrábí již přes 10 let, ale za tuto dobu prošlo mnohými obměnami. Vše proto, aby zákazník obdržel vozidlo moderní s hi-tech prvky, spolehlivé a samozřejmě při rozumné míře údržby. Nicméně orientovat se mezi tím, které z vozidel už roky jezdí po kolejích a které jsou teprve ve výrobě, může být složité. Proto je záměrem tohoto článku popsat jednotlivé typy vozidel z rodiny Panterů a jejich zajímavé nebo unikátní vlastnosti. Vysvětlíme si rozdíly jednotlivých řad a také nahlédneme do plánů do budoucna. Nebudeme se protentokrát věnovat výkonu ani obsaditelnosti vozidel, ty jsou k nalezení v produktových listech firmy Škoda.
ANALÝZA CITLIVOSTI BUZENÍ REZONANCE V TORZNÍ SOUSTAVĚ ZÁVISLÉ NA FREKVENCI BUZENÍ A RYCHLOSTI PRŮJEZDU REZONANCÍ
Authors:   VTS pri Žilinskej univerzite v Žiline, Dybala Vojtěch
Published: January 2024

V rámci výzkumných činností zaměřených na zkoumání přechodových jevů v trakčních pohonech vysoce výkonných kolejových vozidel (lokomotiv), viz obr. 1, byly stanoveny cíle a předpoklady pro různé specifické zaměření prací.
JEDNONÁPRAVOVÝ OTOČNÝ PODVOZEK PRO REGIONÁLNÍ VOZIDLO
Authors:   VTS pri Žilinskej univerzite v Žiline, Heller Petr
Published: January 2024

Železniční dvounápravová vozidla byla v nedávné minulosti oblíbeným dopravním prostředkem na vedlejších, regionálních, neelektrifikovaných tratích. Svou přepravní kapacitou přibližně 50 cestujících, byla někdy nazývána kolejový autobus. I v současné době ještě neztratila svou oblibu.
AKTUÁLNÍ STAV V OBLASTI NETRAKČNÍCH SOUPRAV ŠKODA
Authors:   VTS pri Žilinskej univerzite v Žiline, Kundrata Miroslav , Tížek Jakub
Published: January 2024

Škoda Transportation a.s. a Škoda Vagonka a.s. jsou tradičními výrobci kolejových vozidel v České republice. Kromě standardních produktů, jako jsou tramvaje, elektrické jednotky anebo lokomotivy se v menším měřítku věnují i vývoji, výrobě a homologaci vozových souprav a osobních vozů pro regionální a dálkovou dopravu.
MODELOVÁNÍ TŘECÍ VRSTVY V KONTAKTU KOLA A KOLEJNICE ZA PŘÍTOMNOSTI MAZIV
Authors:   VTS pri Žilinskej univerzite v Žiline, Kvarda Daniel , Omasta Milan , Galas Radovan , Hartl Martin
Published: January 2024

Tribologické procesy v kontaktu kola a kolejnice jsou důležité pro komfortní, spolehlivý a bezpečný provoz kolejových vozidel, jelikož veškeré trakční a brzdné síly jsou přenášeny tímto kontaktem. Již desetiletí je běžnou praxí zvyšování přenosu trakčních a brzdných sil pomocí pískování. Během posledních dekád se rozšířilo cílené řízení tření na temeni kolejnice za účelem snížit tření, opotřebení, hluku a energetických nároků. K tomu jsou využívány modifikátory tření, což jsou látky na bázi oleje, vody nebo ve formě tuhých tyčinek. Pokud uvažujeme hodnotu součinitele tření na suché kolejnici nad 0,6, tak modifikátory tření míří na hodnoty 0,3 – 0,4 [1]. Navíc je potřeba zmínit, že v mnoha publikacích je součinitel tření a součinitel adheze zaměnitelný. Nicméně, součinitel tření primárně definuje poměr třecí a normálové síly za plně skluzového kontaktu. Naopak součinitel adheze, popisuje poměr třecí a normálové síly při valivě-skluzovém kontaktu. Tato definice bude nadále používána pro popis dat získaných v tomto článku.
MODIFIKACE STENDU KOLO - ROTUJÍCÍ KOLEJNICE PRO VÝZKUM PRŮCHODU ELEKTRICKÉHO SIGNÁLU MEZI KOLEM A KOLEJNICÍ
Authors:   VTS pri Žilinskej univerzite v Žiline, Lata Michael , Sýkora Peter
Published: January 2024

V rámci zabezpečovacích systému kolejové dopravy se využívá průchod elektrického signálu mezi koly a kolejnicemi, přesněji řečeno dvojkolí vodivě spojí levou a pravou kolejnici a tím sepne zabezpečovací obvod. Jedná se o systémy, které úzce souvisí s bezpečností železniční dopravy. Z praxe jsou známy případy, kdy průchod elektrického proudu mezi koly a kolejnicí byl zatížen chybovostí, která vedla až k fatálním následkům. Přesto není známo, že by tato oblast byla středem zájmu výzkumu. Tento příspěvek obsahu-je pilotní myšlenky a vstup do možné oblasti výzkumu. Hlavní smysl třeba spatřovat v komplexnosti a jedinečnosti konečné realizace.
Katarini Čufar podelili naziv zaslužna profesorica
Authors: Šernek Milan , Oblak Leon , Merela Maks
Published: January 2024

Na Tednu Univerze v Ljubljani (UL) 2023 so prof. dr. Katarini Čufar podelili naziv zaslužna profesorica, za pomembne prispevke k razvoju znanosti o lesu in dendrokronologije, kakovostno in predano pedagoško in mentorsko delo, organizacijo dela in upravljanje na Univerzi v Ljubljani ter krepitev splošnega ugleda UL doma in v svetu. Univerza je podelila 14 priznanj zaslužnim profesoricam in profesorjem. Tri nove zaslužne profesorice, Lučka Kajfež-Bogataj, Irena Rogelj in Katarina Čufar, prihajajo z Biotehniške fakultete UL.
test submission for upgrade of OJS
Authors: Publicera KB
Published: January 2024

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FEEDBACK IN FORMATIVE ASSESSMENT: STRATEGIES TO OPTIMIZE STUDENT LEARNING
Authors: BOTEZATU Valeria
Published: January 2024

Formative assessment, as an integral part of the learning process, influences student progress. A key component of this process is feedback, the mechanism by which relevant and useful information is provided to students about their performance. Through feedback, students develop their self-assessment and self-reflection skills, take responsibility for their own training, and establish learning objectives. Formative assessment provides a continuous framework for guiding student progress, and feedback provides specific information aimed at improving learning outcomes. Feedback offers a more complete perspective on students’ capabilities and learning needs, allowing teachers to adjust instruction. The objective of this study is to determine the theoretical pedagogical and psychological approaches of feedback in the formative assessment process and to present strategies that involve feedback (feed-up, feed-back, feed-forward) in order to improve student learning. To achieve this objective, theoretical methods of analysis and synthesis of the literature on formative assessment and feedback were applied. From a methodological point of view, the basic empirical method involved the application of a questionnaire addressed to students about their opinion on the feedback given and received during learning activities. The results obtained showed that relevant and individualized feedback is efficient from the students’ perspective in achieving learning objectives. The main conclusion of this study highlights the importance of the feedback system in the formative assessment process for the development of a learning culture based on continuous improvement and the active engagement of students in their own learning process.
EVALUATING THE IMPACT OF A PEDAGOGICAL TRAINING PROGRAM OFFERED TO AWARDED UNIVERSITY TEACHERS
Authors: BALAN Radu , PURTAN Nadia , MLADENOVICI Velibor , ILIE Marian D.
Published: January 2024

A didactic grant competition for academics is organized annually at the West University of Timişoara (WUT), offering a grant to the winners of a public student-centered activity project competition. The teaching grant winners later take part in a program to develop their pedagogical skills in student-centered teaching based on the WUT’s reflexive-collaborative (i.e., RCL) instructional model. Next, during one academic semester, grant winners must implement the RCL instructional model in one specific subject matter. Based on a quantitative quasi-experimental design, this study examined the impact of a pedagogical program offered to the beneficiaries of the 2020 grant competition at both teachers’ and student levels. At the teachers’ level, we measured their conceptions of teaching, teaching approaches, and psychological resources. At the students’ level, we investigated their evaluation of their teachers’ teaching behavior and their learning approaches. Analyses such as Two-way mixed ANOVA, Quade’s ANCOVA, and Mann-Whitney U were conducted to investigate the gathered data. Academics in the EG reported statistically significant improvements in their conceptions of promoting active learning. According to their students, teachers in the experimental group employed more student-centered assessment methods and teaching behaviors that encouraged active learning. Our results also showed that academics in the control group reported higher resilience levels at the end of the academic semester, and according to their students, their more traditional teaching approaches seemed more effective in stimulating their students’ understanding of fundamental concepts. The results could have been more significant regarding the students’ learning approaches. Because of the beginning of the Covid-19 pandemic, we encountered several obstacles in the impact assessment process (e.g., high values at the pretest, the impossibility of matching students’ answers). Although our findings have some limitations, the present article has noteworthy implications for stakeholders involved in in-service teacher training programs, in particular, conducted in higher education institutions. Practical implications of the findings for both academic developers and future research are discussed.
YOUNG CHILDREN’S AGENCY IN NURSERIES: PREMISE FOR LEARNING FOR LIFE
Authors: Ulrich Hygum Cătălina , Hygum Erik
Published: January 2024

In the current landscape of restructuring early childhood education and care (ECEC) services for children under three years old in Romania, this article aims to delve into the concept of child agency. It emphasizes children’s learning for life as a complementary aspect to prevailing discourses that view ECEC solely as a foundation for lifelong learning. Through an exploratory study employing a case study approach within early childhood institutions (crèches), the article scrutinizes the agency of young children. It is immersed in interpreting the agentic child within Romania’s multifaceted national ECEC context, seeking to answer the question: How can the perspective of child agency contribute to the development of ECEC institutions and staff? The authors’ understanding of agency draws inspiration from recent discussions on agential realism, marking an ontological shift within education and sociology (Barad, 2007). Agency, entwined within relationships, navigates between the child’s intentions, daily routines, structures, materiality (Spyrou, 2018), and interactions with staff and peers. Empirical data, presented as vignettes, offer glimpses into the child’s agency during play, meals, and other activities. Insights into how children utilize their bodies, indoor and outdoor spaces, sounds, and materials possess the potential to guide further research in the realm of early childhood education. Additionally, these insights may inform professional development within the ECEC field.
THE ATTITUDE OF ROMANIAN SCHOOL PRINCIPALS TOWARDS INCLUSIVE EDUCATION
Authors: JURCA Andra-Maria , SAVA Simona
Published: January 2024

Many countries face the challenge of inclusion to provide all children with an equitable education. Inclusive education involves a continuous process of meeting the needs of students by providing quality education for all. Research in the field of inclusive education showed the essential role the principal of a school has in developing educational practices and cultures favorable to school inclusion. Studies highlight that the attitude of school principals is related to the commitment of school teachers to implement inclusive education. In this direction, the aim of this paper was to investigate the attitudes of Romanian school principals towards inclusive education. The Multidimensional Attitudes Towards Inclusive Education Scale – MATIES was translated and distributed online, between September-October 2022. It measured the teachers’ attitudes on three dimensions: affective, cognitive, and behavioral. 1040 teaching staff, of which 115 were school principals from the entire country offered valid answers to the questionnaire. The research design was quantitative, non-experimental, correlational, and comparative. The results show that principals are willing to implement inclusive education. They have a more open attitude towards inclusive education compared to teachers, and this is not predicted by seniority in teaching but by experience of working with students with special needs.
Analysis of the load of power transformers with a higher voltage of 6‑10 kV
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, VINOGRADOV ALEKSANDR V.
Published: January 2024

Power transformers 6-10/0.4 kV feeding 0.4 kV rural electric networks operate with low load factors. This leads to significant electricity losses. Optimization of the load of 6‑10/0.4 kV power transformers will increase their energy efficiency. To assess the load and loss of electricity in power transformers with a higher voltage of 6‑10 kV of rural electric networks in the Orel district of electric networks (DEN) of the branch of PJSC Rosseti Tsentr - Orelenergo, the authors carried out an analysis of statistical data obtained from operational and technological group dispatcher logs on the load of power transformers 6‑10/0.4 kV of electric networks for 2016‑2022. As a result, it was found that 880 power transformers (74% of the total number) operate with a load factor of less than 20%. Among the 6‑10/0.4 kV power transformers with rated powers of 63, 100, 160, and 250 kVA, the load factor of less than 20% accounts for 72‑77%. It is established that in power transformers 6‑10/0.4 kV of the Orel DEN, annual losses of idle power are 1.8‑2.9 times higher than the short circuit losses. It is revealed that the share of idling losses for different nominal capacities of power transformers 6‑10/0.4 kV is 65‑74% of the total annual electricity losses. The assessment of the load of power transformers is necessary to develop a number of measures to reduce electricity losses in the 0.4 kV electrical networks of the Orel DEN: disconnecting transformers with seasonal loads; replacing underloaded and overloaded transformers with transformers of the required capacity; re-equipping the fleet of 6‑10 kV power transformers with modern power transformers with energy efficiency of class X2K2 and higher.
IMPLEMENTATION OF FULLY ONLINE MICROTEACHING MODEL TO IMPROVE THE TEACHING COMPETENCE OF ARABIC LANGUAGE PRE-SERVICE STUDENT TEACHERS
Authors: Hisbullah Huda  , Hanifah Umi
Published: January 2024

Pandemic has changed microteaching models from offline to fully online. This requires skills that integrate technology into the lesson planning and teaching practice. This study aims to describe the implementation of fully online microteaching models to improve the teaching competence of Arabic language pre-service student teachers, its problems and solutions. This study uses qualitative descriptive method. Data were collected using observation, interviews, and documentation techniques and analyzed with Miles, Huberman, and Saldana interactive model of qualitative analysis technique. The study results show that the Arabic Microteaching course at the Faculty of Education and Teacher Training of Sunan Ampel Islamic State University was designed to be fully online using two models, namely synchronous and asynchronous models, using the media of Google Classroom and Google Meet. This model has its problems. The limited internet package made the students unable to turn on their cameras. This made the teaching practice less interactive. It also hampered the development of the social skills of the teaching practice students. The problem was overcome by regulating the turn to turn on the camera in the synchronous model and maximizing the offline asynchronous model by getting the students to attend [the class] and by recording the teaching practice in video. In this way, the fully online microteaching model can make Arabic language pre-service student teachers more competent in designing their lesson plans and in practicing digital-based learning creatively and innovatively.
TAʿLĪM AL-ISTIMĀʿ WĀ Al-KALĀM BITAṬBĪQ USLŪB FARĪQ AL-TADRĪS FĪ AL-JĀMI'AH AL-ISLĀMIYAH AL-ḤUKŪMIYAH
Authors: Sabri Hatta , Wildana Wargadinata  , Sutaman
Published: January 2024

The phenomenon of differences in educational background and linguistic abilities of new students, has an impact on the policy of the PBA IAIN Lhokseumawe study program by implementing istima' kalam learning with a team teaching strategy. This study aims to describe; What are the strategies and supporting media used by the lecturer team in learning the istima 'kalam course, in an effort to improve learning activities and students' ability to speak Arabic? This research uses a qualitative approach with the type of case study. Data were collected through in-depth interviews, participant observation and documentation studies. Then the data was analyzed by following the theory of Miles and Huberman which includes reduction after data collection, data presentation and conclusions. The results showed that there was a set of strategies used by team teaching and contributed to the achievement of the process and objectives of the istima' kalam course at the PBA IAIN Lhokseumawea. Among them are determining material that is in accordance with student competence, division of lecturers' tasks in teaching based on the stages of language proficiency competence in lectures, application of direct and indirect learning strategies both independently and in groups, with methods of summarizing, repeating, giving speeches, discussing, debating role playing.
TAHLĪL MA’RIFATI AL-MUḤTAWA AL-TIKNŪLŪJIY AL-TARBAWIY LI MU’ALLIMĪ AL-LUGAH AL-‘ARABIYYAH AL-MIHNIYYIN FI TAṬWĪR ADAWĀT AL-TA’ALLUM
Authors: Ahmad Taufiq  , Arrum Wijaya  , Saqafi Mujeeb Khan
Published: January 2024

In 21st century learning, there is a framework that can be used to determine a teacher's ability to prepare a Learning Implementation Plan (RPP), namely the TPACK framework. Based on research conducted by previous researchers, the results show that there are still many teachers who have low TPCK, and don't even know TPACK. Therefore, this research aims to describe the preparation of lesson plans for class XI mufradāt material at Ma'arif NU Kajen Vocational School, Pekalongan Regency to be able to describe the TPACK of Arabic teachers in preparing mufradāt learning plans. This type of research is qualitative research using field research methods carried out at Ma'arif NU Kajen Vocational School, Pekalongan Regency. Based on the research results, it can be concluded that (1) The preparation of lesson plans for class (2) TPACK competency of classroom Arabic teachers XI at Ma'arif NU Kajen Vocational School, Pekalongan Regency is at the recognizing level, because teachers can utilize ICT innovation and see the arrangement of ICT innovation with content but do not coordinate innovation in their learning.
Pengembangan Modul Ajar Pembelajaran Berdiferensiasi dengan Strategi REACT untuk Mengembangkan Kecakapan Numerasi dan Disposisi Matematis Peserta Didik
Authors: Burhanudin  , Pramesti Santika Lya Diah , Falasyifa Nevita
Published: January 2024

This study aims to produce differentiated learning teaching modules with REACT strategies that are valid, practical, and effective in learning Mathematics on Statistics material. The type of research used is development research. The development procedure is carried out using Four-D steps with simplification into three stages which include define, design, and develop. Product validity is determined based on expert judgment. The practicality of the product is determined based on the responses of students and the results of observations of fellow teachers on the application of learning in class. Product effectiveness is determined based on the achievement of learning outcomes and the level of students' mathematical disposition. The results of the study show that the teaching modules developed: (1) have a very high level of validity with an average score of 4.65; (2) it is practical with an average score of student responses of 4.63 and an average score of observations of fellow teachers of 4.52; and (3) effectiveness is shown by the average score of learning outcomes assessment of 81, the percentage of completeness is 78% and the average score of mathematical disposition is 4.29.
Peningkatan Epistemic Curiosity dan Kemampuan Pemecahan Masalah Matematika Siswa Kelas 7 berbantuan Video Etnomatematika
Authors: Barata Agriat , Mampouw Helti Ligia , Mulyani Sri
Published: January 2024

This research aims to determine the improvement of epistemic curiosity and mathematical problem-solving abilities among 7th grade students based on epistemic curiosity assisted by ethnomathematics videos. This study applied classroom action research by using 2 cycles with 4 stages in each cycle. Data collection techniques implemented in this study were test techniques, questionnaires and observation with quantitative and qualitative analyses. The results of this study obtained that: (1) 90,6% of the students completed the problem-solving test (2) problem solving test mean score of students in cycle 2 was 78.31, (3) the proportion of students’ completeness test increased to 90.6%, (4) the mean value of students’ problem-solving score increased significantly to 78.31% and (5) there was a significant increase in epistemic curiosity at the end of cycle 2. Thus, it can be concluded that the lesson taught so far during the study has an impact on increasing students' mathematical problem-solving abilities.
Keefektifan Model PBL Bernuansa Etnomatematika Berbantuan E-LKPD terhadap Kemampuan Pemecahan Masalah Siswa
Authors: Sofiyani Agita Nindi , Zaenuri
Published: January 2024

This study aims to analyze the effectiveness of the e-LKPD assisted ethnomathematics PBL model on problem-solving skills and analyze the increase in students’ love of local culture after the implementation of the e-LKPD assisted ethnomathematics PBL model. Quantitative approach is used with the type of experimental research. The population of this study were class VII students of SMP Negeri 12 Semarang for the 2022/2023 academic year. By using cluster random sampling technique, class VII A and VII B were selected as the experimental and control classes. Methods of data collection is done by the method of tests, questionnaires, and documentation. Data were analyzed using one-group proportion test, one-group average test, twoproportion difference test, two-mean difference test, and paired t-test. The results showed that: (1) the problem-solving abilities of students who received an ethnomathematics nuanced PBL model assisted by e-LKPD achieved classical learning mastery and fulfilled the average achievement, the proportion of students' problem solving abilities with an ethnomathematics nuanced PBL model assisted by e-LKPD was more than the proportion problem-solving abilities of students with the PBL model, and the average problem-solving ability of students with the ethnomathematics nuanced PBL model assisted by e-LKPD is more than the average problem-solving ability of students with the PBL model, so it can be concluded that the e-LKPD assisted ethnomathematics PBL model is effective against students' problem solving abilities; (2) there is an increase in students' love for local culture after the implementation of the PBL model with an ethnomathematics assisted by e-LKPD.
Etnomatematika Bentuk Bangun Geometri Pola Seni Ukiran Kudus Pada Rumah Adat Jawa
Authors: Ariyanti Ita Erlina , Malasari Putri Nur
Published: January 2024

Ethnomatematics is the application of mathematical concepts in the culture that exists in society. This research was conducted at the Joglo Kudus Carving Art Industry Center located in Garung Lor Village, Kaliwungu District, Kudus Regency, Central Java. The purpose of this research is to explore the concept of geometry in the pattern of the Kudus carving art which is applied to the manufacture of Javanese Traditional Houses. The type of research used is qualitative research using an ethnographic approach. The data collection method was carried out by interviewing 3 carving workers, observation and documentation. The object of this study is the carving motifs that exist in several parts of the Javanese traditional house, including ceilings, tumpang, sunduk, katek, blandar, and umpak. The results obtained from the research show that there is a geometric concept of the art pattern of Kudus carvings found in Javanese traditional houses in the form of straight lines, curved lines, sharp angles, squares, rectangles, trapezoids, parallelograms, rhombuses, circles, semicircles, octagons, pyramids. rectangles, blocks and cubes. This research is expected to make it earsier for students to understand the implementation of mathematics in the surrounding culture.
Penalaran Matematis Siswa dalam Menyelesaikan Masalah Sistem Persamaan Linear Dua Variabel (SPLDV) berdasarkan Gaya Belajar Kelas VIII A SMP Negeri 5 Tulungagung
Authors: Alviyah Shinta Nur , Asyhar Beni
Published: January 2024

Research objectives ((1) To describe the mathematical reasoning of students with an auditory learning style in solving the problem of a system of two-variable linear equations (SPLDV) class VIII A of SMP Negeri 5 Tulungagung. (2) To describe the mathematical reasoning of students with a visual learning style in solving problems of a system of two-variable linear equations (SPLDV) class VIII A of SMP Negeri 5 Tulungagung. (3) To describe the mathematical reasoning of students with kinesthetic learning styles in solving problems of a system of two-variable linear equations (SPLDV) class VIII A of SMP Negeri 5 Tulungagung. This study uses a qualitative approach with a case study type of research. Data collection was carried out using observation, questionnaires, tests and interviews. The analysis technique used is data reduction, data presentation and conclusion. The research subjects taken were six students in class VIII A of SMP Negeri 5 Tulungagung, namely two students with an auditory learning style, two students with a visual learning style and two students with a kinesthetic learning style. The results showed (1) Students with an auditory learning style were able to predict what method to use to solve the questions, but were unable to solve the SPLDV questions well. (2) Students with a visual learning style are able to guess what method is used to solve the problem, understand the steps or methods that can be used in solving this problem. Able to solve mathematical problems in a way or method to draw conclusions from the solutions that have been done and be able to check the validity of an argument. (3) Students with a kinesthetic learning style are able to predict what method to use to solve the problem, but do not write it down on the answer sheet. Understand the steps or methods that can be used in solving SPLDV questions. Able to justify the answers obtained by way of substitution.
Dampak Advance Organizer dan Gaya Belajar Terhadap Kemampuan Pemahaman Konsep Matematis
Authors: Elvaliana Megananda , Farida  , Andriani Siska
Published: January 2024

This study aims to determine the impact of the advance organizer learning model and learning style on students’ ability to understand mathematical concepts on the subject matter of Sistem Persamaan Linear Dua Variabel (SPLDV). This study uses a quantitative method with a quasy experiment design type of research. The population in this study were all students of class VIII SMP Negeri 1 Kotagajah, sampling using cluster random sampling technique, then obtained class VIII A as the control class dan VIII B as the experimental class. The result of the study that there is an influence of the advance organizer learning model on the ability to understand mathematical concepts, there is an influence of learning styles on the ability to understand mathematical concepts, and there is no interaction between thw advande organizer learning model and learning styles on the ability to understand mathematical concepts