bluuebunny/crossref_metadata_2025 huggingface dataset:
Free Radical–Associated Gene Signature Predicts Survival in Sepsis Patients
Authors: Feng Anlin , Pokharel Marissa D. , Liang Ying , Ma Wenli , Aggarwal Saurabh , Black Stephen M. , Wang Ting
Published: April 2024

Sepsis continues to overwhelm hospital systems with its high mortality rate and prevalence. A strategy to reduce the strain of sepsis on hospital systems is to develop a diagnostic/prognostic measure that identifies patients who are more susceptible to septic death. Current biomarkers fail to achieve this outcome, as they only have moderate diagnostic power and limited prognostic capabilities. Sepsis disrupts a multitude of pathways in many different organ systems, making the identification of a single powerful biomarker difficult to achieve. However, a common feature of many of these perturbed pathways is the increased generation of reactive oxygen species (ROS), which can alter gene expression, changes in which may precede the clinical manifestation of severe sepsis. Therefore, the aim of this study was to evaluate whether ROS-related circulating molecular signature can be used as a tool to predict sepsis survival. Here we created a ROS-related gene signature and used two Gene Expression Omnibus datasets from whole blood samples of septic patients to generate a 37-gene molecular signature that can predict survival of sepsis patients. Our results indicate that peripheral blood gene expression data can be used to predict the survival of sepsis patients by assessing the gene expression pattern of free radical–associated -related genes in patients, warranting further exploration.
K+-Driven Cl−/HCO3− Exchange Mediated by Slc4a8 and Slc4a10
Authors: Peña-Münzenmayer Gaspar , George Alvin T. , Llontop Nuria , Mazola Yuliet , Apablaza Natalia , Spichiger Carlos , Brauchi Sebastián , Sarmiento José , Zúñiga Leandro , González Wendy , Catalán Marcelo A.
Published: April 2024

Slc4a genes encode various types of transporters, including Na+-HCO3− cotransporters, Cl−/HCO3− exchangers, or Na+-driven Cl−/HCO3− exchangers. Previous research has revealed that Slc4a9 (Ae4) functions as a Cl−/HCO3− exchanger, which can be driven by either Na+ or K+, prompting investigation into whether other Slc4a members facilitate cation-dependent anion transport. In the present study, we show that either Na+ or K+ drive Cl−/HCO3− exchanger activity in cells overexpressing Slc4a8 or Slc4a10. Further characterization of cation-driven Cl−/HCO3− exchange demonstrated that Slc4a8 and Slc4a10 also mediate Cl− and HCO3−-dependent K+ transport. Full-atom molecular dynamics simulation on the recently solved structure of Slc4a8 supports the coordination of K+ at the Na+ binding site in S1. Sequence analysis shows that the critical residues coordinating monovalent cations are conserved among mouse Slc4a8 and Slc4a10 proteins. Together, our results suggest that Slc4a8 and Slc4a10 might transport K+ in the same direction as HCO3− ions in a similar fashion to that described for Na+ transport in the rat Slc4a8 structure.
Deep Learning-Based Road Pavement Inspection by Integrating Visual Information and IMU
Authors: Hsieh Chen-Chiung , Jia Han-Wen , Huang Wei-Hsin , Hsih Mei-Hua
Published: April 2024

This study proposes a deep learning method for pavement defect detection, focusing on identifying potholes and cracks. A dataset comprising 10,828 images is collected, with 8662 allocated for training, 1083 for validation, and 1083 for testing. Vehicle attitude data are categorized based on three-axis acceleration and attitude change, with 6656 (64%) for training, 1664 (16%) for validation, and 2080 (20%) for testing. The Nvidia Jetson Nano serves as the vehicle-embedded system, transmitting IMU-acquired vehicle data and GoPro-captured images over a 5G network to the server. The server recognizes two damage categories, low-risk and high-risk, storing results in MongoDB. Severe damage triggers immediate alerts to maintenance personnel, while less severe issues are recorded for scheduled maintenance. The method selects YOLOv7 among various object detection models for pavement defect detection, achieving a mAP of 93.3%, a recall rate of 87.8%, a precision of 93.2%, and a processing speed of 30–40 FPS. Bi-LSTM is then chosen for vehicle vibration data processing, yielding 77% mAP, 94.9% recall rate, and 89.8% precision. Integration of the visual and vibration results, along with vehicle speed and travel distance, results in a final recall rate of 90.2% and precision of 83.7% after field testing.
Sports Analytics: Data Mining to Uncover NBA Player Position, Age, and Injury Impact on Performance and Economics
Authors: Sarlis Vangelis , Tjortjis Christos
Published: April 2024

In the intersecting fields of data mining (DM) and sports analytics, the impact of socioeconomic, demographic, and injury-related factors on sports performance and economics has been extensively explored. A novel methodology is proposed and evaluated in this study, aiming to identify essential attributes and metrics that influence the salaries and performance of NBA players. Feature selection techniques are utilized for estimating the financial impacts of injuries, while clustering algorithms are applied to analyse the relationship between player age, position, and advanced performance metrics. Through the application of PCA-driven pattern recognition and exploratory-based categorization, a detailed examination of the effects on earnings and performance is conducted. Findings indicate that peak performance is typically achieved between the ages of 27 and 29, whereas the highest salaries are received between the ages of 29 and 34. Additionally, musculoskeletal injuries are identified as the source of half of the financial costs related to health problems in the NBA. The association between demographics and financial analytics, particularly focusing on the position and age of NBA players, is also investigated, offering new insights into the economic implications of player attributes and health.
Wolf Rock Lighthouse Long-Term Monitoring
Authors: Brownjohn James , Raby Alison , Bassitt James , Antonini Alessandro , Zhu Zuo , Dobson Peter
Published: April 2024

Wolf Rock Lighthouse is a Victorian era masonry structure located in an extreme environment facing the fiercest Atlantic storms off the southwest coast of England whose dynamic behaviour has been studied since 2016. Initially, a modal test was used to determine modal parameters; then, in 2017, a monitoring system was installed that has operated intermittently providing response data for a number of characteristic loading events. These events have included wave loads due to storms, a small UK earthquake, helicopters landing on the helideck, and the grounding of a ship on the reef. This is believed to be the most extensive experimental campaign on any structure of this type. This paper briefly describes a unique project involving the characterisation and measurement of dynamic behaviour due to different forms of dynamic loading.
Larval Frass of Hermetia illucens as Organic Fertilizer: Composition and Beneficial Effects on Different Crops
Authors: Lomonaco Giovanni , Franco Antonio , De Smet Jeroen , Scieuzo Carmen , Salvia Rosanna , Falabella Patrizia
Published: April 2024

Hermetia illucens has received a lot of attention as its larval stage can grow on organic substrates, even those that are decomposing. Black soldier fly breeding provides a variety of valuable products, including frass, a mixture of larval excrements, larval exuviae, and leftover feedstock, that can be used as a fertilizer in agriculture. Organic fertilizers, such as frass, bringing beneficial bacteria and organic materials into the soil, improves its health and fertility. This comprehensive review delves into a comparative analysis of frass derived from larvae fed on different substrates. The composition of micro- and macro-nutrients, pH levels, organic matter content, electrical conductivity, moisture levels, and the proportion of dry matter are under consideration. The effect of different feeding substrates on the presence of potentially beneficial bacteria for plant growth within the frass is also reported. A critical feature examined in this review is the post-application beneficial impacts of frass on crops, highlighting the agricultural benefits and drawbacks of introducing Hermetia illucens frass into cultivation operations. One notable feature of this review is the categorization of the crops studied into distinct groups, which is useful to simplify comparisons in future research.
Proteomic Analysis of Salivary Secretions from the Tea Green Leafhopper, Empoasca flavescens Fabrecius
Authors: Pan Cheng , He Xueyi , Xia Luxia , Wei Kexin , Niu Yuqun , Han Baoyu
Published: April 2024

Saliva plays a crucial role in shaping the compatibility of piercing–sucking insects with their host plants. Understanding the complex composition of leafhopper saliva is important for developing effective and eco-friendly control strategies for the tea green leafhopper, Empoasca flavescens Fabrecius, a major piercing–sucking pest in Chinese tea plantations. This study explored the saliva proteins of tea green leafhopper adults using a custom collection device, consisting of two layers of Parafilm stretched over a sucrose diet. A total of 152 proteins were identified using liquid chromatography–tandem mass spectrometry (LC-MS/MS) following the filter-aided sample preparation (FASP). These proteins were categorized into six groups based on their functions, including enzymes, transport proteins, regulatory proteins, cell structure proteins, other proteins, and unknown proteins. Bioinformatics analyses predicted 16 secreted proteins, which were successfully cloned and transcriptionally analyzed across various tissues and developmental stages. Genes encoding putative salivary secretory proteins, including Efmucin1, EfOBP1, EfOBP2, EfOBP3, Efmucin2, low-density lipoprotein receptor-related protein (EfLRP), EFVg1, and EFVg2, exhibited high expressions in salivary gland (SG) tissues and feeding-associated expressions at different developmental stages. These findings shed light on the potential elicitors or effectors mediating the leafhopper feeding and defense responses in tea plants, providing insights into the coevolution of tea plants and leafhoppers. The study’s conclusions open avenues for the development of innovative leafhopper control technologies that reduce the reliance on pesticides in the tea industry.
Antithrombotic Use Patterns in COVID-19 Patients from Spain: A Real-World Data Study
Authors: Ramirez-Cervantes Karen Lizzette , Campillo-Morales Salvador , García-Poza Patricia , Quintana-Díaz Manuel , Huerta-Álvarez Consuelo
Published: April 2024

Antithrombotics have been widely used to treat and prevent COVID-19-related thrombosis; however, studies on their use at population levels are limited. We aimed to describe antithrombotic use patterns during the pandemic in Spanish primary care and hospital-admitted patients with COVID-19. Methods: A real-world data study was performed. Data were obtained from BIFAP’s electronic health records. We investigated the antithrombotic prescriptions made within ±14 days after diagnosis between March 2020 and February 2022, divided their use into prior and new/naive groups, and reported their post-discharge use. Results: We included 882,540 individuals (53.4% women), of whom 78,499 were hospitalized. The median age was 44.7 (IQR 39–59). Antithrombotics were prescribed in 37,183 (4.6%) primary care subjects and 42,041 (53.6%) hospital-admitted patients, of whom 7505 (20.2%) and 20,300 (48.3%), respectively, were naive users. Prior users were older and had more comorbidities than new users. Enoxaparin was the most prescribed antithrombotic in hospitals, with higher prescription rates in new than prior users (2348.2, IQR 2390–3123.1 vs. 1378, IQR 1162–1751.6 prescriptions per 10,000 cases, p = 0.002). In primary care, acetylsalicylic acid was the most used antithrombotic, with higher use rates in prior than in naïve users. Post-discharge use occurred in 6686 (15.9%) subjects (median use = 10 days, IQR 9-30). Conclusions: Our study identified a consensus on prescribing antithrombotics in COVID-19 patients, but with low use rates in hospitals.
The Association between Untreated and Treated Hearing Loss and Cognitive Performance in Men and Women Aged 60–96 Years: Data from the Swedish “Good Aging in Skåne” Population Study
Authors: Lundgren Paula , Elmståhl Sölve , Ekström Henrik
Published: April 2024

Background/Objectives: Recent decades have witnessed a sharp increase in research investigating the association between hearing loss and cognitive impairment. Few previous studies have stratified for sex when investigating this issue, where results were inconsistent and require further clarification. Thus, the objective was to investigate the association between self-reported hearing loss and levels of cognitive impairment, stratified for sex. Methods: In this cross-sectional study, data were collected from 2001 to 2016. The study sample consisted of 5075 individuals, 2325 (45.8%) men, mean age 68.3 years, and 2750 (54.2%) women, mean age 70.0 years. Multiple variate ordinal regression models were constructed and adjusted for age, marital status, education, physical activity, depressive mood, hypertension, stroke, diabetes, and use of sedatives to investigate associations between groups of self-reported untreated and treated hearing loss and those reporting no hearing loss in relation to levels of cognitive impairment assessed by the Mini-Mental State Examination scale. Results: In men, treated hearing loss was associated with levels of cognitive impairment, odds ratio (OR) = 1.64, 95% confidence interval (CI) = 1.14–2.36. In women, both untreated hearing loss, (OR = 1.45, CI 1.07–1.98) and treated hearing loss (OR= 1.46, CI 1.06–2.04) were associated with levels of cognitive impairment. Conclusions: Hearing loss was found to be associated with cognitive impairment despite hearing aid use as well as awareness amongst physicians. The introduction of screening programs for hearing loss in older adults could be a crucial step for earlier identification of individuals at higher risk of developing cognitive impairment and dementia.
Exploring the Link between Anticoagulation, Cognitive Impairment and Dementia in Atrial Fibrillation: A Systematic Review
Authors: Agarwal Abhimanyu , Mostafa Mohamed A. , Ahmad Muhammad Imtiaz , Soliman Elsayed Z.
Published: April 2024

Background: The impact of oral anticoagulants (OACs) on cognitive impairment and dementia in patients with atrial fibrillation (AF) is not well characterized. This systematic review aims to address this knowledge gap. Methods: SCOPUS and PubMed searches were conducted to identify articles in the English language investigating the association between the use of OACs and cognitive impairment and dementia. We excluded non-original research studies and studies that did not report data on cognitive impairment or included patients who underwent open heart surgery or had psychiatric illnesses or cancer. Results: Out of 22 studies (n = 606,404 patients), 13 studies (n = 597,744 patients) reported a reduction in cognitive impairment/dementia in those undergoing thromboprophylaxis. Using direct oral anticoagulants (DOACs) was associated with a lower incidence of cognitive impairment in 10 studies (n = 284,636 patients). One study found that patients undergoing dual therapy (n = 6794 patients) had a greater incidence of cognitive impairment compared to those undergoing monotherapy (n = 9994 patients). Three studies (n = 61,991 patients) showed that AF patients on DOACs had a lower likelihood of dementia diagnosis than those on vitamin K antagonists (VKAs). Dementia incidence was lower when VKAs were under good control. Conclusions: The use of oral anticoagulants has the potential to prevent cognitive impairment and dementia in patients with AF. Since most of the published research on this subject is observational in nature, more randomized controlled trials are needed to fully understand the effect of anticoagulants on cognitive function.
Clinical Outcomes of Severe Rhinosinusitis Complicated with Cavernous Sinus Syndrome
Authors: Lin Jin-Yi , Liu Chien-Lin , Dai Zheng-Yan , Li Yu-Ting , Tsou Yung-An , Lin Chia-Der , Tai Chih-Jaan , Shih Liang-Chun
Published: April 2024

Background: Various diseases involving the cavernous sinus can cause a condition called cavernous sinus syndrome (CSS), which is characterized by ophthalmoplegia or sensory deficits over the face resulting from the compression effect of internal structure. While tumor compression is the most reported cause of CSS, statistical data on CSS caused by infections are limited. Its risk factors, treatment methods, and clinical outcomes are not well-documented. Methods: In this retrospective study, we reviewed the data of patients admitted to a tertiary medical center from 2015 to 2022 with a diagnosis of acute and chronic sinusitis and at least one diagnostic code for CSS symptoms. We manually reviewed whether patients were involved in two or more of the following cranial nerves (CN): CN III, CN IV, CN V, or CN VI, or at least one of these nerves with a neuroimaging-confirmed lesion in the cavernous sinus. Results: Nine patients were diagnosed with rhinosinusitis-related CSS. The most common comorbidity was type 2 diabetes, and the most common clinical manifestations were diplopia and blurred vision. The sphenoid sinus was the most affected sinus. One patient expired due to a severe brain abscess infection without surgery. The remaining patients underwent functional endoscopic sinus surgery, and 50% of the pathology reports indicated fungal infections. Staphylococcus spp. was the most cultured bacteria, and Amoxycillin/Clavulanate was the most used antibiotic. Only four patients had total recovery during the follow-up one year later. Conclusions: CSS is a rare but serious complication of rhinosinusitis. Patients with diabetes and the elderly may be at a higher risk for this complication. Even after treatment, some patients may still have neurological symptoms.
Role of IL-6, IL-10 and TNFα Gene Variants in Preterm Birth
Authors: Kadivnik Mirta , Plečko Deni , Kralik Kristina , Arvaj Nena , Wagner Jasenka
Published: April 2024

Background: The association of gene variants for interleukin 6 (IL-6) (rs1800796), interleukin 10 (IL-10) (rs1800896) and tumor necrosis factorα (TNFα (rs1800629) with the occurrence of spontaneous preterm birth (PTB) was investigated to determine whether these genetic variants are a risk factor. Methods: A total of 199 blood samples from pregnant women who had given birth prematurely and 200 control blood samples were analyzed to determine single nucleotide polymorphisms (SNPs) of genes for IL-6 (rs1800796), IL-10 (rs1800896) and TNFα (rs1800629). The control samples were samples from pregnant women with term delivery. The isolation of DNA was performed on mini-spin columns according to the manufacturer’s protocol. The quality and purity of the isolated DNA were tested using a Qubit 3 fluorometer. Genotyping was performed with an ABI PRISM 7500 SDS using TaqMan SNP genotyping assays. The genotypes obtained were analyzed using the 7500 Software v2.3 package. Results: Carriers of the A/A genotype for the rs1800629 SNP of the TNFα gene have a 4.81 times greater chance of late-onset PTB compared to carriers of the G/G and A/G genotypes in the recessive inheritance model. The presence of the G/G genotype in the recessive inheritance model compared with the G/A and A/A genotypes for the rs1800896 SNP of the IL-10 gene represents a potentially protective factor, with mothers in the term-birth group having an almost 2-fold lower odds of PTB in general and an almost 10-fold lower odds of early PTB. On the other hand, carriers of the A/G genotype of rs1800896 have a 1.54-fold higher chance of preterm birth in general and a 1.6-fold higher chance of late preterm birth in the superdominant inheritance model compared to the A/A and G/G genotypes in the group of mothers with PTB. In this study, no association was found between PTB and the rs1800796 SNP of the IL-6 gene. Conclusions: rs1800629 in mothers was associated with PTB. rs1800896 shows a potentially protective effect for the occurrence of PTB in this study. No association was found between PTB and rs1800796.
Comment on Grabala et al. Radiological Outcomes of Magnetically Controlled Growing Rods for the Treatment of Children with Various Etiologies of Early-Onset Scoliosis—A Multicenter Study. J. Clin. Med. 2024, 13, 1529
Authors: Tabeling Casper S. , Lemans Justin V. C. , Kruyt Moyo C.
Published: April 2024

We read with great interest the study titled “Radiological Outcomes of Magnetically Controlled Growing Rods for the Treatment of Children with Various Etiologies of Early-Onset Scoliosis—A Multicenter Study” by Grabala and colleagues [...]
Numerical Simulation of Transverse Crack on Composite Structure Using Cohesive Element
Authors: Heriana Heri , Marbun Rebecca Mae Merida Catalya , Hadi Bambang Kismono , Widagdo Djarot , Kusni Muhammad
Published: April 2024

Due to their anisotropic behavior, composite structures are weak in transverse direction loading. produces transverse cracks, which for a laminated composite, may lead to delamination and total failure. The transition from transverse crack to delamination failure is important and the subject of recent studies. In this paper, a simulation of transverse crack and its transition to delamination on cross-ply laminate was studied extensively using a cohesive element Finite Element Method (FEM). A pre-cracked [0/90] composite laminate made of bamboo was modeled using ABAQUS/CAE. The specimen was in a three-point bending configuration. Cohesive elements were inserted in the middle of the 90° layer and in the interface between the 0° and 90° layer to simulate transverse crack propagation and its transition to delamination. A load–displacement graph was extracted from the simulation and analyzed. As the loading was given to the specimen, stress occurred in the laminates, concentrating near the pre-cracked region. When the stress reached the tensile transverse strength of the bamboo, transverse crack propagation initiated, indicated by the failure of transverse cohesive elements. The crack then propagated towards the interface of the [0/90] laminates. Soon after the crack reached the interface, delamination propagated along the interface, represented by the failure of the longitudinal cohesive elements. The result of the numerical study in the form of load–displacement graph shows a consistent pattern compared with the data found in the literature. The graph showed a linear path as the load increased and the crack propagated until a point where there was a load-drop in the graph, which showed that the crack was unstable and propagated quickly before it turned into delamination between the 0o and 90° plies.
Scanning Micro X-ray Fluorescence and Multispectral Imaging Fusion: A Case Study on Postage Stamps
Authors: Gerodimos Theofanis , Patakiouta Ioanna Vasiliki , Papadakis Vassilis M. , Exarchos Dimitrios , Asvestas Anastasios , Kenanakis Georgios , Matikas Theodore E. , Anagnostopoulos Dimitrios F.
Published: April 2024

Scanning micrο X-ray fluorescence (μ-XRF) and multispectral imaging (MSI) were applied to study philately stamps, selected for their small size and intricate structures. The μ-XRF measurements were accomplished using the M6 Jetstream Bruker scanner under optimized conditions for spatial resolution, while the MSI measurements were performed employing the XpeCAM-X02 camera. The datasets were acquired asynchronously. Elemental distribution maps can be extracted from the μ-XRF dataset, while chemical distribution maps can be obtained from the analysis of the multispectral dataset. The objective of the present work is the fusion of the datasets from the two spectral imaging modalities. An algorithmic co-registration of the two datasets is applied as a first step, aiming to align the multispectral and μ-XRF images and to adapt to the pixel sizes, as small as a few tens of micrometers. The dataset fusion is accomplished by applying k-means clustering of the multispectral dataset, attributing a representative spectrum to each pixel, and defining the multispectral clusters. Subsequently, the μ-XRF dataset within a specific multispectral cluster is analyzed by evaluating the mean XRF spectrum and performing k-means sub-clustering of the μ-XRF dataset, allowing the differentiation of areas with variable elemental composition within the multispectral cluster. The data fusion approach proves its validity and strength in the context of philately stamps. We demonstrate that the fusion of two spectral imaging modalities enhances their analytical capabilities significantly. The spectral analysis of pixels within clusters can provide more information than analyzing the same pixels as part of the entire dataset.
Comparison of Surgical Outcomes of Two New Techniques Complementing Robotic Single-Site Myomectomy: Coaxial Robotic Single-Site Myomectomy vs. Hybrid Robotic Single-Site Myomectomy
Authors: Lee Nara , Choi Su-Hyeon , Won Seyeon , Jung Yong-Wook , Kim Seung-Hyun , Lee Jin-Yu , Lim Chul-Kwon , Yang Jung-Bo , Ha Joong-Gyu , Seong Seok-Ju
Published: April 2024

Background: This study aimed to compare surgical outcomes between two new robotic single-site myomectomy (RSSM)-complementary techniques: coaxial robotic single-site myomectomy (Coaxial-RSSM) and hybrid robotic single-site myomectomy (Hybrid-RSSM). Methods: Medical records for 132 women undergoing Coaxial-RSSM and 150 undergoing Hybrid-RSSM, consecutively, were retrospectively reviewed. Patient characteristics and surgical outcomes were assessed and compared after propensity score matching (PSM). Results: In the outcomes of PSM, the Coaxial-RSSM group showed significantly reduced blood loss (79.71 vs. 163.75 mL, p < 0.001) and reduced hospital duration (4.18 ± 0.62 vs. 4.63 ± 0.90) relative to the Hybrid-RSSM group. Conversely, Hybrid-RSSM allowed for a shorter operative time compared with Coaxial-RSSM (119.19 vs. 156.01 min, p = 0.007). No conversions to conventional laparoscopy or laparotomy or any need for the multi-site robotic approach occurred in either group. Postoperative complications, including ileus, fever, and wound dehiscence, showed no statistically significant differences between the two groups. Conclusions: Blood loss was lower with Coaxial-RSSM, and operative time was shorter for Hybrid-RSSM. A follow-up prospective study is warranted for more comprehensive comparison of surgical outcomes between the two techniques.
Cancer Stem Cell Metastatic Checkpoints and Glycosylation Patterns: Implications for Therapeutic Strategies
Authors: Aghamiri Sara Sadat , Amin Rada
Published: April 2024

Cancer stem cells (CSCs), found within tumors, are powerful drivers of disease recurrence and metastasis. Their abilities to self-renew and maintain stem-like properties make treatment difficult, as their heterogeneity and metastatic properties can lead to resistance and limit the effectiveness of standard therapies. Given their significance, CSCs are typically isolated based on combinations of markers, which often indicate heterogeneous populations of CSCs. The lack of consensus in cell characterization poses challenges in defining and targeting these cells for effective therapeutic interventions. In this review, we suggest five promising molecules—ABCB5, CD26, CD66c, uPAR, and Trop-2—chosen specifically for their distinct distribution within cancer types and clinical relevance. These markers, expressed at the cell surface of CSCs, could significantly enhance the specificity of cancer stemness characterization. This review focuses on describing their pivotal roles as biomarker checkpoints for metastasis. Additionally, this review outlines existing literature on glycosylation modifications, which present intriguing epitopes aimed at modulating the stability and function of these markers. Finally, we summarize several promising in vivo and clinical trial approaches targeting the mentioned surface markers, offering potential solutions to overcome the therapeutic resistance of CSCs and addressing current gaps in treatment strategies.
Multi-Scenario Land Use Optimization Simulation and Ecosystem Service Value Estimation Based on Fine-Scale Land Survey Data
Authors: Shu Rui , Wang Zhanqi , Guo Na , Wei Ming , Zou Yebin , Hou Kun
Published: April 2024

Land optimization simulation and ecosystem service value (ESV) estimation can better serve land managers in decision-making. However, land survey data are seldom used in existing studies, and land optimization constraints fail to fully consider land planning control, and the optimization at the provincial scale is not fine enough, which leads to a disconnection between academic research and land management. We coupled ESV, gray multi-objective optimization (GMOP), and patch-generating land use simulation (PLUS) models based on authoritative data on land management to project land use and ESV change under natural development (ND), rapid economic development (RED), ecological land protection (ELP), and sustainable development (SD) scenarios in 2030. The results show that construction land expanded dramatically (by 97.96% from 2000 to 2020), which encroached on grassland and cropland. This trend will continue in the BAU scenario. Construction land, woodland, and cropland are the main types of land used for expansion, while grassland and unused land, which lack strict use control, are the main land outflow categories. From 2000 to 2030, the total amount of ESV increases steadily and slightly. The spatial distribution of ESV is significantly aggregated and the agglomeration is increasing. The policy direction and land planning are important reasons for land use changes. The land use scenarios we set up can play an important role in preventing the uncontrolled expansion of construction land, mitigating the phenomenon of ecological construction, i.e., “governance while destruction”, and promoting food security. This study provides a new approach for provincial large-scale land optimization and ESV estimation based on land survey data and provides technical support for achieving sustainable land development.
The Association between Ovarian Cancer and the Incidence of Newly Developed Dry Eye Disease: A Nationwide Population-Based Study
Authors: Lee Chia-Yi , Yang Shun-Fa , Chang Yu-Ling , Huang Jing-Yang , Chang Chao-Kai
Published: April 2024

We aim to investigate the potential correlation between the presence of ovarian cancer and the development of dry eye disease (DED) via the usage of the Longitudinal Health Insurance Database (LHID) of Taiwan. A retrospective cohort study was executed, and patients with ovarian cancer were selected according to the diagnostic and procedure codes. One ovarian cancer patient was matched to four non-ovarian cancer participants which served as control group, and a total of 4992 and 19,968 patients constructed the ovarian cancer and control groups, respectively. The primary outcome in the current study is the development of DED according to the diagnostic and procedure codes. Cox proportional hazard regression was utilized to produce the adjusted hazard ratio (aHR) and related 95% confidence interval (CI) of DED between the two groups. There were 542 and 2502 DED events observed in the ovarian cancer group and the control group, respectively. The ovarian cancer group illustrated a significantly higher incidence of DED development than the control group after the adjustment of several confounders (aHR: 1.10, 95% CI: 1.01–1.21, p = 0.040). In the subgroup analysis stratified by age, ovarian cancer patients aged older than 60 years showed a higher incidence of DED compared to the non-ovarian cancer population (aHR: 1.19, 95% CI: 1.08–1.28, p = 0.011). In addition, ovarian cancer patients with a disease duration longer than five years also showed higher incidence of DED formation than the non-ovarian cancer population (aHR: 1.13, 95% CI: 1.04–1.22, p = 0.027). In conclusion, the presence of ovarian cancer is associated with higher incidence of subsequent DED, especially in those older than 60 years and with a disease interval of more than five years.
Impact of Structural Compliance of a Six Degree of Freedom Joint Simulator on Virtual Ligament Force Calculation in Total Knee Endoprosthesis Testing
Authors: Kleist Eric , Henke Paul , Ruehrmund Leo , Kebbach Maeruan , Bader Rainer , Woernle Christoph
Published: April 2024

The AMTI VIVO™ six degree of freedom joint simulator allows reproducible preclinical testing of joint endoprostheses under specific kinematic and loading conditions. When testing total knee endoprosthesis, the articulating femoral and tibial components are each mounted on an actuator with two and four degrees of freedom, respectively. To approximate realistic physiological conditions with respect to soft tissues, the joint simulator features an integrated virtual ligament model that calculates the restoring forces of the ligament apparatus to be applied by the actuators. During joint motion, the locations of the ligament insertion points are calculated depending on both actuators’ coordinates. In the present study, we demonstrate that unintended elastic deformations of the actuators due to the specifically high contact forces in the artificial knee joint have a considerable impact on the calculated ligament forces. This study aims to investigate the effect of this structural compliance on experimental results. While the built-in algorithm for calculating the ligament forces cannot be altered by the user, a reduction of the ligament force deviations due to the elastic deformations could be achieved by preloading the articulating implant components in the reference configuration. As a proof of concept, a knee flexion motion with varying ligament conditions was simulated on the VIVO simulator and compared to data derived from a musculoskeletal multibody model of a total knee endoprosthesis.
Looking into the Eyes to See the Heart of Chronic Kidney Disease Patients
Authors: Kislikova Maria , Gaitán-Valdizán Jorge Javier , Parra Blanco José Antonio , García Unzueta María Teresa , Rodríguez Vidriales María , Escagedo Cagigas Clara , Piñera Haces Vicente Celestino , Valentín Muñoz María de la Oliva , Benito Hernández Adalberto , Ruiz San Millan Juan Carlos , Rodrigo Calabia Emilio
Published: April 2024

In patients with chronic kidney disease (CKD), the main cause of morbidity and mortality is cardiovascular disease (CVD). Both coronary artery calcium scoring by computed tomography (CT) and optical coherence tomography (OCT) are used to identify patients at increased risk for ischemic heart disease, thereby indicating a higher cardiovascular risk profile. Our study aimed to investigate the utility of these techniques in the CKD population. In patients with CKD, OCT was used to measure the choroidal thickness (CHT) and the thickness of the peripapillary retinal nerve fiber layer (pRNFL). A total of 127 patients were included, including 70 men (55%) with an estimated glomerular filtration rate (eGFR) of 39 ± 30 mL/min/1.73 m2. Lower pRNFL thickness was found to be related to high-sensitivity troponin I (r = −0.362, p < 0.001) and total coronary calcification (r = −0.194, p = 0.032). In a multivariate analysis, pRNFL measurements remained associated with age (β = −0.189; −0.739–−0.027; p = 0.035) and high-sensitivity troponin I (β = −0.301; −0.259–−0.071; p < 0.001). Severe coronary calcification (Agatston score ≥ 400 HU) was related to a worse eGFR (p = 0.008), a higher grade of CKD (p = 0.036), and a thinner pRNFL (p = 0.011). The ROC curve confirmed that the pRNFL measurement could determine the patients with an Agatston score of ≥400 HU (AUC 0.638; 95% CI 0.525–0.750; p = 0.015). Our study concludes that measurement of pRNFL thickness using OCT is related to the markers associated with ischemic heart disease, such as coronary calcification and high-sensitivity troponin I, in the CKD population.
Complete Mitochondrial Genome and Its Phylogenetic Position in Red Algae Fushitsunagia catenata from South Korea
Authors: Patil Maheshkumar Prakash , Oktavitri Nur Indradewi , Kim Young-Ryun , Yoon Seokjin , Lee In-Cheol , Kim Jong-Oh , Kim Kyunghoi
Published: April 2024

The mitogenome is an important tool in taxonomic and evolutionary studies. Only a few complete mitogenomes have been reported for red algae. Herein, we reported the complete mitochondrial genome sequence of Fushitsunagia catenata (Harvey) Filloramo, G.V. and Saunders, G.W. 2016, a monospecific genus. The genome was 25,889 bp in circumference and had a strongly biased AT of 70.4%. It consisted of 2 rRNAs, 23 tRNAs, and 24 protein-coding genes (PCGs). nad5 (1986 bp) was the largest and atp9 (231 bp) was the smallest PCG. All PCGs used ATG as an initiation codon and TAA as a termination codon, except TAG, which was the termination codon used in the sdh3, rps3, and rps11 genes. The general structure and gene content of the present findings were almost identical to those of other red algae genomes, particularly those of the Rhodymeniales order. The maximum likelihood analysis showed that F. catenata was closely related to Rhodymenia pseudopalmata. The mitochondrial genome data presented in this study will enhance our understanding of evolution in Rhodophyta species.
Magnetoelectric Properties of Multiferroic Composites Based on BaTiO3 and Nickel-Zinc Ferrite Material
Authors: Bochenek Dariusz , Niemiec Przemysław , Brzezińska Dagmara , Dercz Grzegorz , Ziółkowski Grzegorz , Jartych Elżbieta , Grotel Jakub , Suchanicz Jan
Published: April 2024

The purpose of the present study was to learn the morphological, structural, ferroelectric, dielectric, electromechanical, magnetoelectric, and magnetic properties, and DC conductivity of BaTiO3-Ni0.64Zn0.36Fe2O4 (BT-F) multiferroic composites compacted via the free sintering method. The influence of the ferrite content in ceramic composite materials on the functional properties is investigated and discussed. X-ray diffraction studies confirmed the presence of two main phases of the composite, with strong reflections originating from BaTiO3 and weak peaks originating from nickel-zinc ferrite. BT-F ceramic composites have been shown to exhibit multiferroism at room temperature. All studied compositions have high permittivity values and low dielectric loss, while the ferroelectric properties of the BT component are maintained at a high level. On the other hand, magnetic properties depend on the amount of the ferrite phase and are the strongest for the composition with 15 wt.% of F (magnetization at RT is 4.12 emu/g). The magnetoelectric coupling between BT and F phases confirmed by the lock-in technique is the largest for 15 wt.% ferrite. In the present work, the process conditions of the free sintering method for obtaining BT-F multiferroic composite with good electrical and magnetic properties (in one material) were optimized. An improved set of multifunctional properties allows the expansion of the possibilities of using multiferroic composites in microelectronics.
Preparation and Properties of Attapulgite/Brucite Fiber-Based Highly Absorbent Polymer Composite
Authors: Deng Caihong , Zhai Xinming , Li Wenrong , Li Qian , Xiong Rui , Lu Fuyang
Published: April 2024

The ATP-BF-P(HEC-AA-AMPS) composite highly absorbent polymer was copolymerized with acrylic acid (AA) and 2-acrylamido-2-methylpropane sulfonic acid (AMPS) using an aqueous solution method with attapulgite (ATP) and attapulgite (ATP) as a matrix. The prepared ATP-BF-P(HEC-AA-AMPS) was characterized in terms of microstructure and tested for its water absorption capacity, water retention properties, and pH dynamic sensing ability. The results showed that the synthesized ATP-BF-P(HEC-AA-AMPS) had a rough and porous surface and a high water absorption capacity and rate, almost reaching the maximum water absorption around 20 min, and demonstrated excellent water retention performance at low and medium temperatures. ATP-BF-P(HEC-AA-AMPS) has a sensitive dynamic sensing ability in different pH solutions, with a high swelling capacity between pH 6.0 and 10.0. When the pH value exceeded 10.0, the swelling rate decreased rapidly. Additionally, the thermal stability and mechanical strength of the highly absorbent polymers were significantly improved after blending with ATP and BF.
Red Emitting Solid-State CDs/PVP with Hydrophobicity for Latent Fingerprint Detection
Authors: Zhang Zhihong , Han Zhaoxia , Ding Shuhui , Jing Yujing , Wei Zhenjie , Zhang Dawei , Hong Ruijin , Tao Chunxian
Published: April 2024

Fluorescent carbon dots (CDs) are a new type of photoluminescent nanomaterial. Solid-state CDs usually undergo fluorescence quenching due to direct π-π* interactions and superabundant energy resonance transfer. Therefore, the preparation of solid-state fluorescent CDs is a challenge, especially the preparation of long wavelength solid-state CDs. In this research, long wavelength emission CDs were successfully synthesized by solvothermal methods, and the prepared CDs showed good hydrophobicity. The composite solid-state CDs/PVP (Polyvinyl pyrrolidone) can emit strong red fluorescence, and the quantum yield (QY) of the CDs/PVP powder reaches 18.9%. The prepared CDs/PVP solid-state powder was successfully applied to latent fingerprint detection. The results indicate that the latent fingerprints developed by CDs/PVP powder have a fine definition and high contrast visualization effect, which proves that the prepared CDs/PVP has great application potential in latent fingerprint detection. This study may provide inspiration and ideas for the design of new hydrophobic CDs.
Alkalinity Regulation and Optimization of Cementitious Materials Used in Ecological Porous Concrete
Authors: Li Sijiao , Yin Jian , Xu Wenxing , Liu Sizhe , Liu Xiaofei
Published: April 2024

Ecological porous concrete (EPC) is one of the novel formulations of concrete with unique phytogenic properties. However, achieving both low alkalinity and high strength in EPC proves challenging due to the inherently high alkalinity of the pore environment, which hinders the growth of the plant and affects its ecological benefits significantly. This research investigated the utilization of 15 types of chemical admixtures and diatomaceous earth as alkali-reducing agents to optimize the properties of silicate cementitious materials for the applications of EPC. To identify the most effective agents, the pH value and compressive strength of the cement paste were adopted as the screening criteria for the selection of the essential alkali-reducing ingredients. Subsequently, a composite approach combining chemical admixtures and DE was employed to explore the synergistic effects on the pH and strength of silicate cementitious materials. The results revealed that a combination of 8% DE, 5% oxalic acid, and 5% iron sulfate functioned effectively and resulted in desirable performance for the concrete. This synergistic blend effectively consumed a large amount of Ca(OH)2, reducing the pH of cement paste to 10.48 within 3 days. Furthermore, the hydration reaction generated C-S-H with a low Ca/Si ratio, leading to a remarkable increase in the compressive strength of the concrete, reaching 89.7 MPa after 56 days. This composite approach ensured both low alkalinity and high strength in silicate cementitious materials, providing a theoretical basis for the application and promotion of EPC in the ecological field.
Dramatically Enhanced Mechanical Properties of Nano-TiN-Dispersed n-Type Bismuth Telluride by Multi-Effect Modulation
Authors: Lin Shengao , Li Jing , Yan Heng , Meng Xianfu , Xiang Qingpei , Jing Hang , Chen Xiaoxi , Yang Chuting
Published: April 2024

Bismuth telluride (Bi2Te3)-based alloys have been extensively employed in energy harvesting and refrigeration applications for decades. However, commercially produced Bi2Te3-based alloys using the zone-melting (ZM) technique often encounter challenges such as insufficient mechanical properties and susceptibility to cracking, particularly in n-type Bi2Te3-based alloys, which severely limit the application scenarios for bismuth telluride devices. In this work, we seek to enhance the mechanical properties of n-type Bi2Te2.7Se0.3 alloys while preserving their thermoelectrical performance by a mixed mechanism of grain refinement and the TiN composite phase-introduced pinning effect. These nanoscale processes, coupled with the addition of TiN, result in a reduction in grain size. The pinning effects of nano-TiN contribute to increased resistance to crack propagation. Finally, the TiN-dispersed Bi2Te2.7Se0.3 samples demonstrate increased hardness, bending strength and compressive strength, reaching 0.98 GPa, 36.3 MPa and 74 MPa. When compared to the ZM ingots, those represent increments of 181%, 60% and 67%, respectively. Moreover, the thermoelectric performance of the TiN-dispersed Bi2Te2.7Se0.3 samples is identical to the ZM ingots. The samples exhibit a peak dimensionless figure of merit (ZT) value of 0.957 at 375 K, with an average ZT value of 0.89 within the 325–450 K temperature range. This work has significantly enhanced mechanical properties, increasing the adaptability and reliability of bismuth telluride devices for various applications, and the multi-effect modulation of mechanical properties demonstrated in this study can be applied to other thermoelectric material systems.
Porous Silicone Rubber Composite Supported 1,4-Diphenylethynyl Benzene for Hydrogen Absorption with Pd/C Catalyst
Authors: Wang Yu , Xing Tao , Yan Lifeng
Published: April 2024

Hydrogen is a dangerous gas as it reacts very easily with oxygen and may explode; therefore, the accumulation of hydrogen in confined spaces is a safety hazard. Composites consisting of unsaturated polymers and catalysts are a common getter, where the commonly used polymer is 1,4- diphenylethynyl benzene (DEB). Silicone rubber (SR) is a good carrier for hydrogen-absorbing materials due to its excellent chemical stability and gas permeability. In this work, polysiloxane, water, and a emulsifier are ultrasonically injected into a uniform emulsion, and the hydrogen getter DEB-Pd/C (Palladium on carbon) is then added. Under the catalysis of platinum (Pt), the cross-linking agent undergoes a hydrosilylation reaction to cross-link polysiloxane in emulsion to form silicone rubber. Then, the water was removed by freeze-drying, and the loss of water constructed a porous frame structure for silicone rubber, thus obtaining porous silicone rubber. The difference in hydrogen absorption performance between porous silicone rubber and ordinary silicone rubber was compared. It was found that, with the increase in water in the emulsion, the porous frame of silicone rubber was gradually improved, and the hydrogen absorption performance was improved by 243.4% at the highest, almost reaching the theoretical saturated hydrogen absorption capacity. Porous silicone rubber was prepared by emulsion mixing, which provided a new idea for further improving the hydrogen absorption performance of silicone rubber.
Influence of Interface Type on Dynamic Deformation Behavior of 3D-Printed Heterogeneous Titanium Alloy Materials
Authors: Li Anmi , Luo Yumeng , Wang Boya , Song Xiaoyun
Published: April 2024

Using the Split Hopkinson Pressure Bar technique, strain-limited dynamic compressive loading experiments were performed on TA1/TA15 heterostructure (HS) materials. The plastic deformation mechanisms, fracture forms, and energy absorption properties of an HS material with a metallurgical bonding interface (MB) and an HS material without a metallurgical bonding interface (NMB) are compared and analyzed. The results show that there is no significant difference between the two deformation mechanisms. The fracture forms are all “V-shaped” fractures within the TA1 part. The NMB was carried for 57 μs before failure and absorbed 441 J/cm3 of energy. The MB was carried for 72 μs before failure and absorbed 495 J/cm3 of energy. Microstructure observations show that there is a coordinated deformation effect near the MB interface compared to the NMB, with both TA1 and TA15 near the interface carrying stresses. This causes an enhancement of the MB load-bearing time and a 12% increase in energy absorption.