bluuebunny/crossref_metadata_2025 huggingface dataset:
BOLSHEVIK MODERNIZATION OF RUSSIA IN THE 20-30s OF THE 20th CENTURY AND ITS MILITARY-TECHNOLOGICAL, PERSONNEL AND POLITICAL CONSEQUENCES FOR THE FIGHT AGAINST NAZISM IN THE FIRST YEARS OF WORLD WAR II (ACCORDING TO V.M. CHERNOV)
Authors: Malikhin Konstantin G. , Schekatunov Oleg V.
Published: November 2021

The article is devoted to the assessment of the results of the Bolshevik modernization of Russia in the 20-30s of the 20th century in its military-technological, personnel and political aspects on the example of the struggle of Soviet Russia with Nazi Germany in the first years of World War II and the Great Patriotic War. The relevance of the topic is due to the contradictions in the assessments of the Bolshevik transformations of the 20-30s. In historiography and in the public mind, disputes about the role of these transformations for victory in the Second World War and WWII are not abating. This is especially true of the first years of the Second World War, which led the USSR to disaster. This problem was analyzed by an outstanding theoretician, leader of the Socialist-Revolutionaries and a figure of the Russian intellectual emigration V.M. Chernov. As historical sources, the article considers a number of such interesting documents as the letter of V.M. Chernov to I. V. Stalin in 1942 and issues of the emigre magazine “For Freedom!ˮ published in the USA. Using these sources as an example, the position of V.M. Chernov on the successes and failures of the Bolshevik reform of Russia and the related victories and defeats of the Red Army in the early years of the War. It is proved that the failures of the USSR in the first years of the War were the result of a number of political and personnel problems, some of which were caused by the accelerated "assault" nature of the Bolshevik modernization of the 1920s and 1930s.
Finding the Uncomfortable Solution: Responsible Innovation in Humanitarian Energy
Authors:   Coventry University, UK, Robinson Benjamin , Halford Alison ,   Coventry University, UK, Gaura Elena ,   Coventry University, UK
Published: November 2021

As a result of the lessons learned from the Humanitarian Engineering and Energy for Displacement (HEED) project around the different perceptions of innovation between key energy stakeholders, this paper looks to engage with questions around ensuring innovation in the humanitarian sector, and more specifically, humanitarian energy, is responsible. How can we define responsible? Is responsible innovation a theoretical nicety or can it ensure a just energy transition as outlined by the SDGs? What does responsible innovation look like in reality? Building to our underlying research question: what is the state-of-the-art in responsible innovation for humanitarian energy and how is it implemented at project level?
Yvette i pogoda w Europie – maj 2014 r.
Authors: Degirmendžić Jan , Walisch Marek
Published: November 2021

Szansa wystąpienia niżu śródziemnomorskiego, który w dalszych etapach cyklu życiowego przemieści się nad Europę Środkowo-Wschodnią, rośnie wiosną i osiąga maksimum w kwietniu i maju (Degirmendžić, Kożuchowski 2014). Wiosną 2014 r. pogoda rozwinęła się według przewidywalnego scenariusza – serię niżów przemieszczających się na wschód znad Północnego Atlantyku w pierwszej połowie maja zakończył klin wyżowy rozcią- gnięty południkowo znad Morza Norweskiego nad Azory. Cyrkulacja strefowa została zablokowana i wzrosło prawdopodobieństwo wystąpienia quasi-południkowych trajektorii niżów.
Starość i młodość jako nieustannie aktualne, uniwersalne motywy literackie i kulturowe – wprowadzenie do zbioru studiów
Authors: Kuran Michał
Published: November 2021

The study presents selected examples of functioning in the literature and culture the category of senility and youth in the idea of Antiquity, as well as examples from the circle of literature of Renaissance and Baroque (in the context especially of Parenetics). The versatility of these categories present also proverbs existing in such works of culture as Erazm of Rotterdam’s Adagia and Ezop’s fables. The examples of meetings, but also confrontations, and well as independent functioning motifs of senility and youth in the art are among others paintings of Teodor Axentowicz and Wlastimil Hofman. The study also pays attention to the transformations, which have occurred in the functioning of senility and youth in the culture of recent years, including changes in defining their borders. Deliberations present afterwards course of conference devoted to the titled issue and also they describe motifs, which have guided to group studies collected in the volume.
Dziecko w twórczości księdza Jana Twardowskiego
Authors: Stępińska Katarzyna
Published: November 2021

Father Jan Twardowski is a religious poet. His poetry is a masterpiece of wonder at the beauty of the world and its creatures. Children have a special place in his work. Not only he wrote about children, but also he wrote for them. The child in his poetry is someone who is constantly surprised, who is asking a lot of questions, who wants to explore the world and admire him, because everything he sees is something new and full of mystery. His poetry is also very widely read by adults because they can discover a child in themselves and they may again and more fully explore the world.
¿Cuáles son los factores que limitan la presencia femenina en la creatividad publicitaria?
Authors:   , Hernández Quispe Carolina Andrea
Published: November 2021

El presente artículo pretende mostrar parte de la realidad de la configuración, a nivel de género, de los equipos del departamento de creatividad en la industria publicitaria limeña. Se presenta, en un primer momento, una investigación teórica que recorre la historia de la mujer en el ámbito laboral y luego, de manera específica en la publicidad. Esto se respalda con indagación cualitativa realizada a través del método de entrevistas, a los principales directores de esta industria. Así, se responde, de manera no concluyente, cuáles son los principales factores que limitan la presencia femenina en los departamentos creativos de las agencias de publicidad.
Die Wirkung von Hedgefonds Activism auf Aktienrenditen von Unternehmen im S&P 1500
Authors:   , Schmitz Jonas Tobias
Published: November 2021

In der vorliegenden Dissertation wird die Wirkung von Hedgefonds Activism auf Aktienrenditen von Unternehmen im S&P 1500 untersucht. Hierbei wird insbesondere analysiert, wie sich die Kommunikation von Hedgefonds auf Aktienrenditen auswirkt. Die empirischen Analysen bauen auf Datensätzen auf, die Bekanntgaben des Einstiegs und des Ausstiegs von Activism betreibenden Hedgefonds bei börsennotierten Unternehmen umfassen.
POLITICAL BRANDING SAMSUL ARIFIN DALAM PEMILIHAN KEPALA DESA TAMBAKBOYO KECAMATAN TAWANGSARI KABUPATEN SUKOHARJO TAHUN 2018
Authors: Firmansyah Muhammad Iqbal , Hendrarti Dwi Windyastuti Budi
Published: November 2021

This research describes about political branding and political branding communication strategies of Samsul Arifin in Headman election of Tambakboyo in 2018. Samsul Arifin is youngest headman candidate in Sukoharjo who won the headman election in 2018 against incumbent who had two periods of leadership. This study uses descriptive qualitative method with in-depth interviews data collection techniques with Samsul Arifin and the Samsul team coordinator then it was analyzed by using Lorann Downer’s theory of political branding strategies. The results are Samsul has brand himself as a young man who will build the village government that has been damaged in the previous period. Samsul delivered his political brand by collaborating with the RT in appointing Samsul as a headman candidate, the youths are conditioning their parents, socializing in the RT forum, asking for blessing to the residents of hamlet (sub village) I, speech during registration of candidate, forming a Samsul’s wings team, anticipating of vote buying which usually do in early morning, using banner and making t- shirts for voters who are in Samsul’s side. The political brand must be implemented according to the concept, so it is not damaging candidate’s brand.
PRO DAN KONTRA TERHADAP KEBIJAKAN MANTAN NARAPIDANA KORUPSI DALAM PENCALONAN LEGISLATIF
Authors: Fauzi Alvin , Haryadi Haryadi
Published: November 2021

his study discusses the prohibition of ex-corruption convicts who registered themselves as legislative candidates. Even this is supported by Article 7 paragraph 1 letter g PKPU. However, the Bawaslu (Election Oversight Body) allowed it and it is also supported by Yasonna Laoly, Minister of Justice and Human Rights of Indonesia, with the consideration that the regulations stipulated by PKPU contradict Law No. 7 of 2017 which states that ex-convicts are considered to have the same political rights as other citizens, a right guaranteed by the constitution. This study employs political contestation theory that explains the actions or processes that are disputed, for example ideological contestation on social policy, as well as political electoral theory that explains a system for making political decisions in which individuals gain the power to decide through competitive over people’s voices.
PERAN ELITE SUKU TENGGER DALAM PEMILU 2019 DI DESA ARGOSARI KECAMATAN SENDURO KABUPATEN LUMAJANG
Authors: Mubarok Muhammad Kemal , Priyatmoko Priyatmoko
Published: November 2021

This research focuses on the roles of the elite in the Tengger Tribe in the last 2019 elections, more precisely discussing matters related to authority and authority in the successful holding of the 2019 elections yesterday. This elite which is divided into several segments is a channel for the aspirations of the lower classes. The minimal knowledge of the Tengger Tribe regarding politics and government makes some actions and choices tend to follow the local elites. In this case, the elite in the eyes of Max Weber, dividing it into three types according to social relations. The three types are traditional authority types which in Tengger society are occupied by adat pandhita shamans, charismatic authority types which are occupied by Hindu religious leaders and Islamic religious leaders, and the last is formal legal authority type occupied by the Argosari village head. Concerning the 2019 General Elections, each has its own mass base in terms of the type of authority. Even though the village head, traditional shaman, Muslim and Hindu community leaders, do differ in their political choices, they still uphold democratic values along with their traditional values. Some philosophies related to democracy and elections according to the elite and the Tengger community are the same as the life guidelines handed down from their ancestors. Tengger Tribe living guidelines include, among others, Tenggering benevolence, Sesanti Titi Luhur, Disathru, and Hila-Hila which are instructions for democracy. The implementation of elections and democracy in peace will be realized when the Tengger Tribe people follow the guidelines of their ancestors. Thus, the motto adopted by the local community can be realized "Memayu Hayuning Bawono and Sepi Ing Pamrih Rame Ing Gawe”.
Regulation of the Romanian Accountancy Profession – 100 Years Celebration. A History Lesson for Today’s Professionals
Authors:   Vasile Alecsandri” University of Bacau, Romania, Botez Daniel
Published: November 2021

On July 15th 1921, the Official Journal of Romania witnessed the publication of the Law on the organization of the Body of Licensed and Expert Accountants. The longtime wish of higher school of business graduates thus became true, they established their first association in 1888. Since then, until the law was published, the regulation of the accountancy profession was the main topic of various discussions and attitudes, of several pleadings addressed to public authorities and debates held at the meetings of a multitude of institutes representing these graduates’ interests, grouped within the Union of Business Schools Graduates, subsequently the Body of Higher Schools of Business Graduates, which acquired legal personality in 1916. There were also other subjects, directly related to accountants’ activity, that drew the graduates’ attention, both before and after the law was published, such as: censors’ statute, accounting expertise, visas on trade registers; business education reform; the Body’s relations with authorities. A number of public figures linked their faith to asserting the accountancy profession, its regulation and the ongoing representation of its interests. We should mention here, among many other, Nicolae Butculescu, I. St. Rasidescu, Vasile M. Ioachim, Petru Drăgănescu-Brateş, Grigore Trancu-Iaşi, George Alesseanu, Spiridon Iacobescu, Alexandru Sorescu. An important activity of the Body was the organisation of congresses. They began taking place every two years, uninterruptedly, starting 1923 until 1939. The activity of the Body of Expert and Licensed Accountants was influenced by the political and social events of its time, especially since 1935. Beginning with 1940, its activity saw a significant decrease.
Can the Audit Opinion Influence the Portfolio Investment Decisions? The Case of Listed companies
Authors:   Faculty of Economics and Business Administration, “Alexandru Ioan Cuza” University of Iasii,, Aevoae George Marian , Robu Ioan Bogdan ,   Faculty of Economics and Business Administration, "Alexandru Ioan Cuza” University of Iasii,, Dicu Roxana Manuela ,   Faculty of Economics and Business Administration, “Alexandru Ioan Cuza” University of Iasii, Herghiligiu Ionut Viorel ,   Faculty of Industrial Design and Business Management, “Gheorghe Asachi” Technical University of Iasii
Published: November 2021

As a part of their strategic transactions, corporations often acquire stakes in other companies that do not grant them control, but allow them to use their resources to increase their profitability, access technological progress and innovation, develop products, or obtain dividends. The main objective of this paper is to identify the factors influencing the behavior of acquirers who buy securities in the capital of the target companies, listed on Bucharest Stock Exchange, without intending to control them. The study aims to describe two dimensions of the buyers' behavior, when they buy shares that do not lead to the control of the target companies (below 50%). The first dimension refers to the buyer's decision to invest in a certain share of capital, influenced by the profitability of the target company and its market capitalization (dimensions of their performance), but also by the audit opinion on the annual financial statements. The relationship is positive and significant. The second dimension focuses on the decision of the acquirers to invest or not in a blue-chip company (top companies, considered the most efficient and stable on the financial market), with the main purpose of obtaining dividends or trading the respective securities on the capital market, in order to generate cash flows. The result shows that investors buy small shares in blue chip companies, compared to other companies, taking into account their performance and the audit opinion on the annual financial statements.
Solutions and Drift Homogenization for a Class of Viscous Lake Equations in
Authors: Tong Maoting
Published: November 2021

In this paper we study solutions and drift homogenization for a class of viscous lake equations by using the method of semigroups of bounded operators. Suppose that the initial value i.e.,for some Hölder continuous function onwith smooth function value satisfying and Then the initial value problem (2) for viscous lake equations has a unique smooth local strong solution. Using this result we study the drift homogenization for three-dimensional stationary Stokes equation in the usual sense
Iotivity Cloud-enabled Platform for Energy Management Applications
Authors: Mandza Yann Stephen
Published: November 2021

In developing countries today, population growth and the penetration of higher standard of living appliances in homes has resulted in a rapidly increasing residential load. In South Africa, the recent rolling blackouts and electricity price increase only highlighted this reality calling for sustainable measures to reduce the overall consumption and peak load. The dawn of the smart grid concept, embedded systems and ICTs have paved the way to novel HEMS design. In this regard, the Internet of Things (IoT), an enabler for smart and efficient energy management systems is seeing increasing attention for optimizing HEMS design and mitigate its deployment cost constraints. In this work, we propose an IoT platform for residential energy management applications focusing on interoperability, low-cost, technology availability and scalability. We focus on the backend complexities of IoT Home Area Networks (HAN) using the OCF IoTivity-Lite middleware. To augment the quality, servicing and reduce cost and complexities, this work leverages open-source Cloud technologies from Back4App as BaaS to provide consumer and Utilities with a data communication platform within an experimental study illustrating time and space agnostic “mind-changing” energy feedback, Demand Response Management (DRM) and appliance operation control via a HEM App via an Android smartphone.
The possibilities of ensuring the security of the software product in the conditions of unauthorized access
Authors:   Platinum Software Development Company, Dziatkovskii Anton , Hryneuski Uladzimir ,   Platinum Software Development Company
Published: November 2021

Ensuring the security of a software product in the conditions of large companies, taking into account confidential financial and corporate data, is quite an urgent topic in 2021-2023. Over the past year, the number of leaks of confidential information reached a historic peak, together with cyber attacks, and amounts to 114 identified cases. In modern conditions, software security testing is aimed at identifying security errors and design flaws at all stages of the software development lifecycle. At the same time, at the design stage, this type of work should be provided in order to facilitate the implementation of these characteristics in the final version of the security-related system. Research has shown that there is a wide range of opportunities for developing and using security testing software. These options may differ in implementation technologies, cost and other tactical and technical indicators, characteristics of individual elements, and so on. The main task of developing a software security testing method is to develop, improve and select models, methods and tools that belong to a subset and provide maximum software security indicators. Our approach allows us to prevent any penetration into the information system, while maintaining 100% security of confidential files and the system as a whole. The threat prevention model works with the help of proactive technology, and if you calculate the economic effect of these measures, it can be different, depending on the value of the enterprise’s information itself, and can also be calculated in millions of US dollars. The reliability of the results of mathematical modelling of technologies for creating and implementing «penetration testing» tools is evaluated. The experimental results showed that for all the studied data types, the confidence probability that the value of the statistical value «does not deviate» from the mathematical expectation by more than 1 is 0.94.
Immunomodulation Effect of Kaempferia galanga Ethanolic Extract On In Vitro Lymphocyte Cell Proliferation
Authors: Sugiartanti Dianita Dwi , Wiedosari Ening
Published: November 2021

Kaempferia galanga L. is a traditional medicine with antitumor properties, as indicated by its immunomodulatory activities. This study aimed to determine the effect of K. galanga on lymphocyte cell proliferation activity as an indicator of immunomodulatory properties. This study was conducted at the Indonesian Research Center for Veterinary Science (February to April 2018). The immunomodulatory activity of the extract was evaluated with an in vitro splenocyte proliferation assay. The assay was based on cellular enzymatic synthesis to transform the XTT from formazan tetrazolium as an indicator. The K. galanga extract was obtained by 96% ethanol extraction. The test was conducted in an aseptic condition, consisted of five treatment groups with three replications each.  Three groups of splenocyte cell culture, each with extract concentration of 2.5 µg.ml-1, 25 µg.ml-1, and 250 µg.ml-1, as well as a positive (Concanavalin A/Con A) and negative (cell only) control. The cell suspension (10x104 cells/ml) was distributed on 96-well plates and cultured following the treatment groups. The same five plates were made for five days of observation and retrieved daily by observing an Elisa reader at 450 nm. The extract of K. galanga at 2.5 µg.ml-1, 25 µg.ml-1, and 250 µg.ml-1 significantly (P <0.05) promoted splenocyte proliferation compared to control.  Therefore, it was expected that K. galanga has a high potential to be used as immunomodulators. Hence, further investigations should be done to clarify the mechanisms of the immunomodulatory effect of K. galanga as an antitumor in vivo.
Community Engagement for Malaria Elimination in the Greater Mekong Subregion: a Qualitative Study Among Malaria Researchers and Policymakers
Authors: Kaehler Nils , Adhikari Bipin , Cheah Phaik Yeong , von Seidlein Lorenz , Day Nicholas PJ , Dondorp Arjen M , Pell Christopher
Published: November 2021

IntroductionCommunity engagement has increasingly received attention in malaria research and program interventions, particularly as countries approach closer to malaria elimination. Although strategies and aspects of community engagement are constantly developing, little is known about how those who implement research or programs view community engagement. This article explores the perspectives of researchers and policy makers in the Greater Mekong Subregion (GMS) on community engagement for malaria control and elimination. MethodsSemi-structured interviews were conducted among 17 policymakers and 15 senior researchers working in the field of malaria. All interviews were audio-recorded and transcribed in English. Transcribed data were analyzed using deductive and inductive approach in QSR NVivo. Themes and sub-themes were generated. ResultsResearchers and policymakers emphasized the importance of community engagement in promoting participation in malaria research and interventions. Building trust with the community was seen as crucial. Respondents emphasized involving authority/leadership structures and highlighted the need for intense and participatory engagement. Geographic remoteness, social, cultural, and linguistic diversity were identified as barriers to meaningful engagement. Local staff were described as an essential ‘connect’ between researchers or policy makers and prospective participants. Sharing information with community members, using various strategies such as visualization of message including creative and participatory methods were highlighted. ConclusionsAs malaria continues to decline across the GMS, countries have set elimination goals. In this context, policy makers and researchers involved in malaria prevention and control in the region viewed community engagement as crucial for promoting participation in research or programmatic interventions. Given the difficulties of the “last mile” to elimination, sustained investment in community engagement is needed in isolated areas of the GMS where malaria transmission continues.
Biosorption of Remazol Brilliant Blue R Dye onto Chemically Modified and Unmodified Yarrowia lipolytica Biomass
Authors: ARACAGÖK YUSUF DORUK
Published: November 2021

Remazol Brilliant Blue R (RBBR) is a widely used carcinogenic and toxic dye. This study focused on RBBR dye from aqueous solution using potassium permanganate, cetyltrimethylammonium bromide (CTAB) modified, and unmodified Yarrowia lipolytica biomass as biosorbent. RBBR dye biosorption studies were carried out as a function of pH, initial dye concentration, biosorbent dose, contact time, and temperature. The pH of the aqueous solution strongly influenced the biosorption percent of RBBR dye. The highest dye biosorption capacity yield was obtained at pH 2-3 as well as above pH 3, very low yield biosorption of RBBR was observed. No differences were found between chemically modified and unmodified biomass in terms of RBBR dye biosorption capacity. In the first 15 min, almost 50% RBBR dye was removed from the solution and reached equilibrium within,180 min at pH 2. Biosorption isotherm obeyed Langmuir isotherm model and pseudo-second-order kinetic model.
Maternal Anxiety Affects Embryo Implantation Via Impairing Adrenergic Receptor Signaling in Decidual Cells
Authors: Wu Jinxiang , Lin Shu , Huang Pinxiu , Qiu Lingling , Jiang Yufei , Zhang Ying , Meng Nan , Meng Meiqing , Wang Lemeng , Deng Wenbo , Liu Zhao , Guo Chuanhui , Lu Jinhua , Wang Haibin , Kong Shuangbo
Published: November 2021

Psychological stress is closely related to recurrent pregnancy failure (RPF) and infertility, but the mechanism is still unclear. The human endometrium plays a vital role in providing the site for embryo implantation; many factors have been implicated in unsatisfactory endometrial receptivity in RPF. In the current study, we found that women with pregnancy loss or infertility have a higher serum epinephrine level, indicating a potential correlation between psychological stress and pregnancy failure. RNA-sequencing of the tissues from endometrial receptive phase of the normal and embryo recurrent implantation failure (RIF) and discovered that stress hormones could affect the functional status of the receptive phase of the endometrium. Subsequent analysis showed that the epinephrine signaling acts as an important regulator of endometrial receptivity through PI3K-AKT and FOXO1 signaling pathways. We also found that patients with RIF have attenuated expression of alpha-2C-adrenergic receptor (ADRA2C), and its down regulation would inhibit the promotion of adrenergic signal-mediated decidualization. We treated the early pregnancy model of stressed mice and observed that they had high serum epinephrine levels, defective uterine adrenergic receptor expression and low pregnancy rates. All together, our findings indicate that mental stress during early pregnancy can alter the functional status of endometrial receptivity.
GMDH-type Neural Networks for Predicting Financial Time Series: A Study of Informational Efficiency of Stock Markets
Authors: Jakaite L , Ciemny M , Selitskiy S , Schetinin Vitaly
Published: November 2021

A theory of Efficient Market Hypothesis (EMH) has been introduced by Fama to analyse financial markets. In particular the EMH theory has been proven in real cases under different conditions, including financial crises and frauds. The EMH assumes to examine the prediction accuracy of models designed on retrospective data. Such prediction models could be designed in different ways that motivated us to explore Machine Learning (ML) methods known for building models providing a high prediction performance. In this study we propose a ``deep'' learning method for building high-performance prediction models. The proposed method is based on the Group Method of Data Handling (GMDH) that is the deep learning paradigm capable of building multilayer neural-network models of a near-optimal complexity on given data. We show that the developed GMDH-type neural network has outperformed the models built by the conventional ML methods on the Warsaw Stock Exchange data. It is important that the complexity of the designed GMDH-type neural-networks is defined by the number of layers and connections between neurons. The performances of models were compared in terms of the prediction errors. We report a significantly smaller prediction error of the proposed method than that of the conventional autoregressive and "shallow’’ neural-network models. This finally allows us to conclude that traders will be advantaged by the proposed method.
Single-step additive manufacturing of silicon carbide through laser-induced phase separation
Authors: Karakoc Omer , Mao Keyou , Xi Jianqi , Koyanagi Takaaki , Liu Jian , Szlufarska Izabela , Katoh Yutai
Published: November 2021

Silicon carbide (SiC) tubes are fabricated through femtosecond high-energy ultra-short pulsed laser powder bed fusion (LPBF) additive manufacturing. Widespread implementation of pulsed LPBF of SiC compounds is hampered by a poor understanding of the material–laser interaction for such short processing times and under such extreme thermal regimes, which is due to the complexity of SiC materials. In this investigation, binding and phase separation mechanisms of SiC powders driven by pulsed laser–material interactions are elucidated using numerous state-of-the-art analytical tools as well as theoretical calculations. Partial disintegration of 6H-SiC powders into silicon and carbon during laser sintering is demonstrated to bind SiC powder particles together with no measurable SiO2 phase formation. During femtosecond laser–material interactions, 6H-SiC decomposes into silicon and carbon at high temperatures and localized high pressure state on the process. Decomposition of 6H-SiC is corroborated by density functional theory (DFT) calculations. Furthermore, relatively large (~200 nm–1.5 µm) pockets of 6H-SiC, 3C-SiC, repetitive nanoscale-pattern “nanobreathing” (~2–20 nm) of 6H-SiC and highly oriented pyrolytic graphite spheres are formed. The experimental observations indicate the viability of the synthesis of highly oriented spheroidal pyrolytic graphite and 3C-SiC and 6H-SiC grains, and thin elements of silicon and carbon, using high energy short-pulse laser irradiation.
Mortality from snakebite envenomation: an analysis from the Global Burden of Disease Study 2019
Authors: Roberts Nicholas , Johnson Emily , Zeng Scott , Hamilton Erin , Abdoli Amir , Alahdab Fares , Alipour Vahid , Ancuceanu Robert , Andrei Catalina , Anvari Davood , Arabloo Jalal , Ausloos Marcel , Awedew Atalel , Badiye Ashish , Bakkannavar Shankar , Bhalla Ashish , Bhardwaj Nikha , Bhardwaj Pankaj , Bhaumik Soumyadeep , Bijani Ali , Boloor Archith , Cai Tianji , Carvalho Felix , Chu Dinh Toi , Couto Rosa , Dai Xiaochen , Desta Abebaw , Do Hoa , Earl Lucas , Eftekhari Aziz , Esmaeilzadeh Firooz , Farzadfar Farshad , Fernandes Eduarda , Filip Irina , Foroutan Masoud , Franklin Richard , Gaidhane Abhay , Gebregiorgis Birhan , Gebremichael Berhe , Ghashghaee Ahmad , Golechha Mahaveer , Hamidi Samer , Haque Syed , Hayat Khezar , Herteliu Claudiu , Ilesanmi Olayinka , Islam M Mofizul , Jagnoor Jagnoor , Kanchan Tanuj , Kapoor Neeti , Khan Ejaz , Khatib Mahalaqua , Khundkar Roba , Krishan Kewal , Kumar G Anil , Kumar Nithin , Landires Iván , Lim Stephen , Madadin Mohammed , Maled Venkatesh , Manafi Navid , Marczak Laurie , Menezes Ritesh , Meretoja Tuomo , Miller Ted , Mohammadian-Hafshejani Abdollah , Mokdad Ali , Monteiro Francis , Moradi Maryam , Nayak Vinod , Nguyen Cuong , Nguyen Huong , Nuñez-Samudio Virginia , Ostroff Samuel , Padubidri Jagadish , Pham Hai , Pinheiro Marina , Pirestani Majid , Syed Zahiruddin , Rabiee Navid , Radfar Amir , Rahimi-Movaghar Vafa , Rao Sowmya , Rastogi Prateek , Rawaf David , Rawaf Salman , Reiner Robert , Sahebkar Amirhossein , Samy Abdallah , Sawhney Monika , Schwebel David , Senthilkumaran Subramanian , Shaikh Masood , Skryabin Valentin , Skryabina Anna , Soheili Amin , Stokes Mark , Thapar Rekha , Tovani-Palone Marcos , Tran Bach , Travillian Ravensara , Velazquez Diana , Zhang Zhi-Jiang , Naghavi Mohsen , Dandona Rakhi , Dandona Lalit , James Spencer , Pigott David , Murray Christopher , Hay Simon , Vos Theo , Ong Kanyin
Published: November 2021

Venomous snakebite is an important cause of preventable death. The World Health Organization (WHO) set a goal to halve snakebite mortality by 2030. We used verbal autopsy and vital registration data to model the proportion of venomous animal deaths due to snakes by location, age, year, and sex, and applied these proportions to venomous animal contact mortality estimates from the Global Burden of Disease 2019 study. In 2019, 63,400 people (95% uncertainty interval 38,900–78,600) died globally from snakebites, which was equal to an age-standardized mortality rate (ASMR) of 0.8 deaths (0.5–1.0) per 100,000 and represents a 36% (2–49) decrease in ASMR since 1990. India had the greatest number of deaths in 2019, equal to an ASMR of 4.0 per 100,000 (2.3-5.0). We forecast mortality will continue to decline, but not sufficiently to meet the WHO’s goals. Improved data collection should be prioritized to help target interventions, improve burden estimation, and monitor progress.
CXCL13 Correlates with Prognosis, Immune Infiltration, and T Cell Exhaustion in Ovarian Cancer
Authors: Duan Hailing , Lv Ying , Liao Pan , Wang Yiming , Zheng Zhifang , Qu Honglan
Published: November 2021

Background: CXCL13 is an important chemotactic factor closely related to the biology of cancer cells. The presence work focused on exploring the significance of CXCL13 in prognosis prediction and analyzing the associations of CXCL13 with T cell function and immune infiltration in various cancers, especially ovarian cancer (OV).Purpose: CXCL13 is associated with prognosis, immune infiltration, and T cell failure of ovarian cancer.Methods: The Oncomine, GEPIA2 and HPA databases were utilized for analyzing CXCL13 levels within diverse cancers. The significance of CXCL13 in prognosis prediction was explored through Kaplan-Meier Plotter, TCGAportal, and GEPIA2. Meanwhile, the associations of CXCL13 with clinical stage, gene marker sets, and immune infiltration were examined through TISIDB, GEPIA2, and TIMER databases. Besides, CXCL13 was screened to analyze the biological processes (BPs) and KEGGs enriched by co-expression genes. The miRWalk database was employed for analyzing the gene-miRNA interaction network of CXCL13 within OV.Results: CXCL13 expression decreased in many cancers, which predicted the dismal survival of OV. CXCL13 upregulation was in direct proportion to the increased immune infiltration degrees of many functional T cells (like exhausted T cells) and immune cells. Additionally, some critical genes of exhausted T cells, such as TIM-3, PD-1, LAG3, TIGIT, GZMB, and CXCL13, were closely associated with CXCL13. Moreover, CXCL13 was related to immune response regulatory signaling pathway, leukocyte cell-cell adhesion, cell adhesion molecules (CAMs), and hematopoietic cell lineage. Conclusion: CXCL13 can serve as a biomarker to predict cancer prognosis, particularly OV. CXCL13 upregulation remarkably elevates the immune infiltration degrees of numerous immune cells, like mast cells, CD8+ T cells, natural killer (NK) cells, and dendritic cells (DCs). Furthermore, CXCL13 is suggested to be closely related to exhausted T cells, which may be used as a candidate regulating factor for T cell exhaustion within OV. Detecting CXCL13 levels contributes to prognosis prediction and CXCL13 regulation within exhausted T cells, which provides a new approach to maximizing the anti-OV efficacy of immunotherapy.
Validating Field Regeneration Capacity for Selected Accessions of Gossypium hirsutum Using Callus Induction and Regeneration Capacity
Authors: Tajo Sani Muhammad , Pan Zhao , Sadau Salisu Bello , Iqbal Shahid , Yusuf KM , Chen Baojun , Hu Daowu , Wang Liru , Mehari Teame Gereziher , Ajadi Abolare Adijat , Bello Babatunde Kazeem , Sammani Tajo , Mahmood Tahir , Sale Ali Ibrahim , Auta Umar , Geng Xiaoli , Du Xiongming
Published: November 2021

Gossypium hirsutm undergoes a rapid clonal propagation to regenerate a mature plant through tissue culture. In this research, cotton leaf regeneration level for 21 accessions in the field (new leaves) was observed after the first harvest, and a comparison between field regeneration level and callus induction with its regeneration capacity (new shoots and roots) for the same 21 accessions was carried out. During the flowering stage of Gossypium hirsutum, biochemical (Proline), physiological (chlorophyll and carotenoid content) analysis was carried out. Phenotypic observations (plant height, leaf area, fresh leaf weight, dry leaf weight, flower and boll number) were also carried out on 21 accessions for each accession. Callus induction and regeneration capacity of roots and shoots for hypocotyl, cotyledons and shoot tip tissues was used to validate field regeneration capacity through analysis of variance. ZS061, LuMian378, JiMian863, and ZS065 have highest drought tolerance while ZhongMianSuo24, LiaoYangDuoMaoMian, and BeiZheGongSheMian have the lowest tolerance to drought stress. Accessions with both field and callus regeneration capacity were identified.
C -reactive protein promotes tumor progression in Hepatocellular Carcinom by 1 interacting with Ephrin type B receptor 3
Authors: Yang Yi Xuan , She Sha , Yang Min , Li Shi Ying , Hu Huai Dong , Ren Hong
Published: November 2021

C-reactive protein (CRP), an acute phase protein, has been increasingly implicated in various tumors, and the role of CRP is positively correlated with invasion and metastasis in hepatocellular carcinoma cells. However, the mechanism of CRP affecting HCC progression remains poorly investigated. The present study investigated the role of CRP in HCC and the underlying mechanisms. We first found that CRP was significantly upregulated in HCC tissues and HCC cells, the expression level correlated with the metastatic ability of HCC cells. Knockdown of CRP significantly suppresses migration and invasion capacity in HCC cells. Through a proteomic analysis of CRP co-immunoprecipitation complexes, the Eph receptor B3 was identified as a new CRP interactor. Then we found that the expression and functions of EphB3 were consistent with CRP in HCC. In addition, co-immunoprecipitation and immunofluorescence assays suggested that EphB3 was able to interact with MAPK/ERK to activate MAPK/ERK signaling pathways. Furthermore, we showed that CRP can induce the phosphorylation of MAPK/ERK by binding EphB3. Our findings showed that CRP increased HCC cells migration and invasion by binding EphB3 to activate MAPK/ERK signaling pathways. It suggested that CRP may become a prognostic factor and a potential therapeutic target for liver cancer.
U-shaped Association Between Apolipoprotein B and All-Cause Mortality: Results from the National Health and Nutrition Examination Surveys
Authors: yan mengqi , Liu Xiaocong , Huang Yuqing , Yu Yuling , Zhou Dan , Feng Yingqing
Published: November 2021

BackgroundApolipoprotein B (apoB), a significant component directly reflecting the number of atherogenic lipoprotein particles, gradually becomes a more conducive indicator to control blood lipids. However, epidemiological evidence on its relationship with mortality is limited, especially with all-cause mortality. MethodsParticipants from the National Health and Nutrition Examination Survey during 2007-2014 were grouped according to the apoB quartiles (15-76, 77-92, 93-110, 111-345mg/dL). We performed Cox proportional hazards models and Kaplan-Meier survival curves to evaluate the relationships of apoB with all-cause and cardiovascular mortality. Restricted cubic spline and piecewise linear regression were performed to detect their non-linear relationships. ResultsIn general, we enrolled 10375 participants among United States adults (mean age 46.3 ± 16.9, 47.88% men). On average, participants were followed up for 69.2 months, among whom 533 (5.14%) and 91 (0.88%) deaths were observed due to all -causes and cardiovascular diseases, respectively. After adjusting for confounders, apoB was independently associated with an elevated risk of cardiovascular death (hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.03-1.24). However, in the third quartile of apoB, the risk of all-cause death decreased significantly (HR, 0.71; 95% CI, 0.56-0.91). Moreover, the non-linear relationship between apoB and all-cause death demonstrated an increased risk at both low and high level apoB concentrations, divided by the threshold point of 108 mg/dl. Conclusion﻿Elevated apoB was significantly associated with an increased risk for cardiovascular mortality, while its association with all-cause mortality was non-linear correlated, with an increased risk at both low and high apoB levels.
Effect of Foliar Spraying of Organic and Inorganic Selenium Fertilizers On Selenium Accumulation and Speciation During Different Stages of Rice Growth
Authors: Yuan Zhengqing , Long Weixiong , Liang Ting , Zhu Menghan , Luo Xiaoyun , Fu Lu , Hu Zhongli , Zhu Renshan , Wu Xianting
Published: November 2021

Aims

Most crops are supplemented with selenium (Se) through the exogenous addition of inorganic selenium fertilizer. There is a lack of in-depth research on organic selenium fertilizers. Meanwhile, the dosage range between human selenium deficiency and selenium toxicity is narrow, so the selenium content of agricultural products needs to be controlled within a reasonable interval.
Methods W

e analyzed and compared the Se accumulation and speciation in rice during three different growth stages (late tillering stage, initiate heading stage, and full heading stage) using three selenium fertilizers, selenite, fermented Se, and potassium Selenocyanoacetate (Se-AAF) via the foliar application.
Results

The selenium content in rice sprayed with organic selenium fertilizer was controlled in the relatively safe range and met the human selenium supplement requirement compared to the sprayed sodium selenite, which was too high of a dose. The percentage of organic Se and protein Se in brown rice was found to be similar in all three Se fertilizers. The highest organic selenium content of 91.57% was found in the grain of rice at the full heading stage by spraying Se-AAF. The main Se species in the grain was selenomethionine (SeMet), which reached 80% of the total selenium. Se-methyl selenocysteine(SeMeCys) was found only in Se-AAF. The grain quality showed that all three Se fertilizers increased the consistency of gelatinization.
Conclusions

Appropriately delaying the spraying time and selecting organic Se fertilizer as the Se source can help to produce green and safe selenium-rich rice.
On the Tribological Properties of RGO-MoS2 Composites Surface Modified by Oleic Acid
Authors: LIU TianXia , Qin jian , Wang Jian , Li jing
Published: November 2021

Purpose To study the effect of oleic acid surface modified RGO/MoS2 composite lubricating additives on the friction and wear properties of 10# White Oil (10# WO). Method The influence of different concentrations of reduction graphene oxide/molybdenum disulfide (RGO-MoS2) and oleic acid surface modified reduction graphene oxide/molybdenum disulfide (OA-RGO-MoS2) on the lubricating properties in 10# WO was investigated by using a four-ball long-term friction and wear tester. The microscopic morphology, lattice structure, composition and element valence of the prepared material were characterized by scanning electron microscope, Raman spectroscopy, X-ray diffractometer, X-ray photoelectron spectroscopy, element analyzer and other instruments. The diameter, structure, morphology, composition and element valence state of the wear scar were obtained by multifunctional universal tool microscope, scanning electron microscope and X-ray photoelectron spectroscopy. Result In the RGO-MoS2 white oil system, when 0.4 wt% RGO-MoS2 was added, the anti-friction effect was the best, and the average friction coefficient (AFC) reduced by 21.8%. When 0.2 wt% RGO-MoS2 was added, the anti-wear effect was the optimal, and the average wear scar diameter (AWSD) decreased by 12.4%. In the OA-RGO-MoS2 white oil system, when 0.2 wt% OA-RGO-MoS2 was added, the anti-friction and anti-wear effects were the best, and the AFC reduced by 33.3%, and AWSD reduced by 14.1%. Conclusion Compared with RGO-MoS2, OA-RGO-MoS2 has a higher degree of graphitization, larger interlayer spacing, lower degree of layered accumulation, higher MoS2 load, and weaker thermal stability. Both lubricating additives have good anti-friction and anti-wear effects at low concentrations, and the anti-friction and anti-wear effects are more prominent after being modified by oleic acid. Analysis of friction mechanism shows that a lubricating protective film containing iron, oxygen, molybdenum, carbon, and sulfur is formed through adsorption or tribochemical reaction during the friction process, which improves the lubrication state and plays a role in reducing friction and anti-wear.
Determinants of Clinician and Patient to prescription of antimicrobials: case of Mulanje, Southern Malawi
Authors: Chalusa Morris , Khuluza Felix , Bandawe Chiwoza
Published: November 2021

BackgroundAntimicrobial resistance is an emerging problem in low- and middle-income countries. The problem is exacerbated by inappropriate prescription of antimicrobials. Factors leading to overuse or inappropriate prescription of antimicrobials by the cadre of medical assistants, clinical technicians and clinical officers have received limited attention. This study investigated factors that influence prescription behaviours of antimicrobials among clinical officers in various health facilities in Mulanje district, Southern Malawi. MethodsIn-depth interviews (n=18) and focus group discussions (n=2) were conducted with COs from four health facilities in Mulanje district. Purposive sampling was done to arrive at a sample size of 30 health cadres. ResultsParticipants pointed out that patient preferences, belief and clinicians’ inadequate education on this issue were among the factors that contribute to inappropriate antimicrobial prescription. 75-% of clinicians showed lack of knowledge on the definition of antibiotic and antimicrobial resistance. ConclusionInappropriate use of antimicrobials is facilitated by prescribing decisions made by clinicians who are greatly influenced by their patients. Interventions aimed at improving antimicrobial prescription should target both clinicians and patients.
Therortical Studies and Investagting of Selected Potnet CDK2 Inhibitors as Anticancer Agents
Authors: Abunuwar Mohammad J , Dahadha Adnan A
Published: November 2021

In this study eight selected of the most potent cyclin dependent kinase 2 inhibitors in which targeting adenosine triphosphate -pocket site theoretically investigated to support literature information of frontier molecular orbitals, molecular electrostatic maps, and global chemical reactivity descriptors such as chemical hardness, chemical softness, chemical potential, electronegativity and electrophilicity of cyclin dependent kinase 2 inhibitors. Calculation and three-dimensional plotting were achieved through Gaussian 09W and Gausview 6 software’s utilizing density functional theory quantum modeling applying both hybrids extended and not extended basis set. Crystal structure of CDK2 with inhibitors was obtained from protein data bank and visualized through PyMol Schrödinger software to assign polar and non-polar interactions of inhibitors with enzyme. A promising conclusion trend obtained in this research regarding to molecules that could have an inhibition activity toward the cyclin dependent kinase 2 enzymes. Our theoretical investigation emphasizes that, the anti-cancer activity has directly relationship with value of chemical hardness and chemical softness, where the most potent compounds was the pyrazolopyrimidine and imidazole pyrimidine and they have higher chemical hardness value and at the same time lower value of chemical softness compared with the rest of compounds.
Optimization for Morphology of Grinding Layer on Textured Laser Cladding Grinding Tool
Authors: Zhao Xufeng , Li Changhe , Yu Tianbiao
Published: November 2021

In order to improving the grinding performance of laser cladding textured grinding tool (LCTGT) under high speed grinding process, the topography shape (height, width and height/width ratio) of laser cladding grinding layers on LCTGT were designed with RSM (response surface method) through optimizing laser cladding processing parameters and laser cladding layers structure parameters that based on Archimedes helix coefficients. The LCTGTs were produced with optimized laser cladding parameters and structural parameters for laser cladding grinding layers. The results showed that laser cladding parameters of 397W of laser power, 3.56 mm/s of the laser scanning speed and 0.91 r/min of powder feeding rate and structure parameters of laser cladding layers of 6-10-10 can meet requirement.