bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Different Walnut and Hazelnut Leaf Compost Treatments on Yield and Phenolic Composition of Lactuca sativa L.
Authors: Medic Aljaz , Solar Anita , Hudina Metka , Veberic Robert , Zamljen Tilen
Published: July 2023

The use of compost made from the leaves of Juglans regia has long been controversial because of its inhibitory effect due to the presence of juglone. Therefore, the aim of our study was to replicate the typical habits of farmers and gardeners, where the dried leaves are collected at the end of the season and placed in a composter. Then, the effects of the different treatments on the yield of the plant (lettuce), secondary metabolism, and possible toxicity of the compost of the grown plant were evaluated. The lowest yield of lettuce was obtained in soil with composted walnut and hazelnut leaves, while the highest yield was recorded in in soil with compost control, soil with composted walnut leaves and grass with the addition of composting agent and soil with composted walnut leaves with addition of composting agent. Some allelochemicals were still present in the compost but at such low levels that they did not affect yield. We suggest that dry walnut leaves and cut grass can be used for composting, while dry hazelnut leaves still contain some allelochemicals after two years that significantly inhibit plant growth and thus yield, so we would not recommend their use for composting.
The Association of the Publication of a Proposed Public Charge Rule with Preterm Births among Uninsured Foreign-Born Latinx Birthing People in the United States
Authors: Choi Sung W.
Published: July 2023

Following the inauguration, the Trump administration authorized a series of anti-immigrant policies, including modifications to the public charge regulation. This study analyzed the effect of the publication of a proposed public charge rule in 2018 on the risk of preterm birth between uninsured and privately insured Latinx birthing people in the United States by using natality files from the National Center for Health Statistics. In total, 1,375,580 Latinx birthing people reported private insurance as their primary source of delivery from 2014 to 2019, while 317,056 Latinx birthing people reported self-pay as their primary source of delivery during the same period. After the publication of the proposed public charge rule in 2018, the odds of preterm birth among uninsured foreign-born Latinx birthing people increased by 6.2% compared with privately insured foreign-born Latinx birthing people (OR: 1.062; 95% CI: 1.016, 1.110). On the other hand, the odds of preterm births among uninsured US-born Latinx birthing people did not significantly increase after the publication of the proposed rule compared with privately insured US-born Latinx birthing people. These findings suggest the publication of the public charge rule proposed in 2018 may be associated with adverse birth outcomes among uninsured foreign-born Latinx birthing people in the United States.
H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development
Authors: Zhu Jun-yi , Liu Chen , Huang Xiaohu , van de Leemput Joyce , Lee Hangnoh , Han Zhe
Published: July 2023

Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with congenital heart disease. However, in vivo functional data for many of the methyltransferases in the context of the heart are limited. Here, we used the Drosophila model system to investigate different histone 3 lysine 36 (H3K36) methyltransferases for their role in heart development. The data show that Drosophila Ash1 is the functional homolog of human ASH1L in the heart. Both Ash1 and Set2 H3K36 methyltransferases are required for heart structure and function during development. Furthermore, Ash1-mediated H3K36 methylation (H3K36me2) is essential for healthy heart function, which depends on both Ash1-complex components, Caf1-55 and MRG15, together. These findings provide in vivo functional data for Ash1 and its complex, and Set2, in the context of H3K36 methylation in the heart, and support a role for their mammalian homologs, ASH1L with RBBP4 and MORF4L1, and SETD2, during heart development and disease.
A Methodology to Assess the Sloshing Effect of Fluid Storage Tanks on the Global Response of FLNG Vessels
Authors: Hernández-Ménez Diego F. , Félix-González Iván , Hernández-Hernández José , Herrera-May Agustín L.
Published: July 2023

The sloshing effect of fluid storage tanks of a Floating Liquefied Natural Gas (FLNG) vessel causes variations in its global motion response. These acceleration and motion alterations can affect the safe performance of the FLNG vessels. The classification societies’ rules are employed to standardize the storage tanks’ configuration of FLNG vessels. Herein, we report a methodology to assess the sloshing effect on the global motion response of an FLNG vessel considering four geometrical arrangements of tanks and different fluid filling fractions. This methodology includes the hydrodynamic effect in operating and storm conditions from the Gulf of Mexico using a return period of 100 years. In addition, our methodology considers the influence of the internal fluid of each tank to estimate the accelerations and motions of the vessel. This methodology can be implemented to estimate the stability of an FLNG vessel under different environmental conditions. Thereby, the naval engineers could choose the best geometrical configuration of the storage tanks for safe behavior of a vessel under different operating and extreme environmental conditions.
The Potential of Metarhizium anisopliae Blastospores to Control Aedes aegypti Larvae in the Field
Authors: Gomes Simone Azevedo , Carolino Aline Teixeira , Teodoro Thais Berçot Pontes , Silva Gerson Adriano , Bitencourt Ricardo de Oliveira Barbosa , Silva Carlos Peres , Alkhaibari Abeer M. , Butt Tariq M. , Samuels Richard Ian
Published: July 2023

Entomopathogenic fungi are promising as an environmentally benign alternative to chemical pesticides for mosquito control. The current study investigated the virulence of Metarhizium anisopliae blastospores against Aedes aegypti under both laboratory and field conditions. Virulence bioassays of conidia and blastospores were conducted in the laboratory, while field simulation bioassays were conducted under two conditions: totally shaded (TS) or partially shaded (PS). In the first bioassay (zero h), the larvae were added to the cups shortly after the preparation of the blastospores, and in the subsequent assays, larvae were added to the cups 3, 6, 9, and 12 days later. The survival of the larvae exposed to blastospores in the laboratory was zero on day two, as was the case for the larvae exposed to conidia on the sixth day. Under TS conditions, zero survival was seen on the third day of the bioassay. Under PS conditions, low survival rates were recorded on day 7. For the persistence bioassay under PS conditions, low survival rates were also observed. Metarhizium anisopliae blastospores were more virulent to Ae. aegypti larvae than conidia in the laboratory. Blastospores remained virulent under field simulation conditions. However, virulence rapidly declined from the third day of field bioassays. Formulating blastospores in vegetable oil could protect these propagules when applied under adverse conditions. This is the first time that blastospores have been tested against mosquito larvae under simulated field conditions, and the current study could be the basis for the development of a new biological control agent.
Research on the Rheological Characteristics of Wind Power Grease Based on Rheological Parameters
Authors: Peng Han , Li Songyin , Shangguan Linjian , Zhang Hai , Zhao Defang
Published: July 2023

Our research scrutinizes the impact of grease rheological properties on the lubrication performance of wind turbine spindle bearings. The rheological behavior of three distinct commercial wind turbine greases was examined with a rotational rheometer. Investigations into the viscoelastic, flow, and viscosity–temperature attributes of the grease under varying temperatures were conducted, and the rheological parameters were fitted utilizing the Herschel–Bulkley (H–B) model. Constitutive equations of the grease derived from fitting the H–B model can efficaciously predict its rheological properties and viscosity–temperature behavior for wind power spindle bearings at disparate temperatures.
Multi-Objective Optimization of AISI P20 Mold Steel Machining in Dry Conditions Using Machine Learning—TOPSIS Approach
Authors: Abbas Adel T. , Sharma Neeraj , Alsuhaibani Zeyad A. , Sharma Abhishek , Farooq Irfan , Elkaseer Ahmed
Published: July 2023

In the present research, AISI P20 mold steel was processed using the milling process. The machining parameters considered in the present work were speed, depth of cut (DoC), and feed (F). The experiments were designed according to an L27 orthogonal array; therefore, a total of 27 experiments were conducted with different settings of machining parameters. The response parameters investigated in the present work were material removal rate (MRR), surface roughness (Ra, Rt, and Rz), power consumption (PC), and temperature (Temp). The machine learning (ML) approach was implemented for the prediction of response parameters, and the corresponding error percentage was investigated between experimental values and predicted values (using the ML approach). The technique for order of preference by similarity to ideal solution (TOPSIS) approach was used to normalize all response parameters and convert them into a single performance index (Pi). An analysis of variance (ANOVA) was conducted using the design of experiments, and the optimized setting of machining parameters was investigated. The optimized settings suggested by the integrated ML–TOPSIS approach were as follows: speed, 150 m/min; DoC, 1 mm; F, 0.06 mm/tooth. The confirmation results using these parameters suggested a close agreement and confirmed the suitability of the proposed approach in the parametric evaluation of a milling machine while processing P20 mold steel. It was found that the maximum percentage error between the predicted and experimental values using the proposed approach was 3.43%.
L-Quasi (Pseudo)-Metric in L-Fuzzy Set Theory
Authors: Chen Peng , Meng Bin , Ba Xiaohui
Published: July 2023

The aim of this paper is to focus on the metrization question in L-fuzzy sets. Firstly, we put forward an L-quasi (pseudo)-metric on the completely distributive lattice LX by comparing some existing lattice-valued metrics with the classical metric and show a series of its related properties. Secondly, we present two topologies: ψp and ζp, generated by an L-quasi-metric p with different spherical mappings, and prove ψp=ζp′ if p is further an L-pseudo-metric on LX. Thirdly, we characterize an equivalent form of L-pseudo-metric in terms of a class of mapping clusters and acquire several satisfactory results. Finally, based on this kind of L-metric, we assert that, on LX, a Yang–Shi metric topology is Q−CI, but an Erceg metric topology is not always so.
A Social Media Knowledge Retrieval Method Based on Knowledge Demands and Knowledge Supplies
Authors: Miao Runsheng , Huang Yuchen , Zhang Zhenyu
Published: July 2023

In large social media knowledge retrieval systems, employing a keyword-based fuzzy matching method to obtain knowledge presents several challenges, such as irrelevant, inaccurate, disorganized, or non-systematic knowledge results. Therefore, this paper proposes a knowledge retrieval method capable of returning hierarchical, systematized knowledge results. The method can match the knowledge demands according to the keyword input by users and then present the knowledge supplies corresponding to the knowledge demands as results to the users. Firstly, a knowledge structure named Knowledge Demand is designed to represent the genuine needs of social media users. This knowledge structure measures the popularity of topic combinations in the Topic Map, so the topic combinations with high popularity are regarded as the main content of the Knowledge Demands. Secondly, the proposed method designs a hierarchical and systematic knowledge structure, named Knowledge Supply, which provides Knowledge Solutions matched with the Knowledge Demands. The Knowledge Supply is generated based on the Knowledge Element Repository, using the BLEU similarity matrix to retrieve Knowledge Elements with high similarity, and then clustering these Knowledge Elements into several knowledge schemes to extract the Knowledge Solutions. The organized Knowledge Elements and Knowledge Solutions are the presentation of each Knowledge Supply. Finally, this research crawls posts in the “Autohome Forum” and conducts an experiment by simulating the user’s actual knowledge search process. The experiment shows that the proposed method is an effective knowledge retrieval method, which can provide users with hierarchical and systematized knowledge.
Modification of the Large Parameter Approach for the Periodic Solutions of Nonlinear Dynamical Systems
Authors: Ismail A. I. , Amer T. S. , Amer W. S.
Published: July 2023

This paper focuses on the modification of the large parameter approach (LPA), a novelty procedure, for estimating the periodic solutions of two degrees-of-freedom (DOF) autonomous quasi-linear systems with a first integral. This strategy is crucial because it provides an effective approach to recognizing approximate solutions to problems for which it is impossible to obtain exact solutions. These problems arise in the fields of physics, engineering, aerospace, and astronomy. They can be solved analytically using several perturbation approaches that depend on a small parameter that can be recognized according to the initial conditions and the body parameters of each problem. Therefore, we propose a large parameter instead of a small one to solve the aforementioned 2DOF systems, as well as provide a comparison between the suggested procedure and the previous approaches.
Improving Newton–Schulz Method for Approximating Matrix Generalized Inverse by Using Schemes with Memory
Authors: Cordero Alicia , Maimó Javier G. , Torregrosa Juan R. , Vassileva María P.
Published: July 2023

Some iterative schemes with memory were designed for approximating the inverse of a nonsingular square complex matrix and the Moore–Penrose inverse of a singular square matrix or an arbitrary m×n complex matrix. A Kurchatov-type scheme and Steffensen’s method with memory were developed for estimating these types of inverses, improving, in the second case, the order of convergence of the Newton–Schulz scheme. The convergence and its order were studied in the four cases, and their stability was checked as discrete dynamical systems. With large matrices, some numerical examples are presented to confirm the theoretical results and to compare the results obtained with the proposed methods with those provided by other known ones.
[1,2,4]triazolo[4,3-a]quinoxaline as Novel Scaffold in the Imiqualines Family: Candidates with Cytotoxic Activities on Melanoma Cell Lines
Authors: Patinote Cindy , Raevens Sandy , Baumann Amélie , Pellegrin Eloise , Bonnet Pierre-Antoine , Deleuze-Masquéfa Carine
Published: July 2023

Cutaneous melanoma is one of the most aggressive human cancers and is the deadliest form of skin cancer, essentially due to metastases. Novel therapies are always required, since cutaneous melanoma develop resistance to oncogenic pathway inhibition treatment. The Imiqualine family is composed of heterocycles diversely substituted around imidazo[1,2-a]quinoxaline, imidazo[1,2-a]pyrazine, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline scaffolds, which display interesting activities on a panel of cancer cell lines, especially melanoma cell lines. We have designed and prepared novel compounds based on the [1,2,4]triazolo[4,3-a]quinoxaline scaffold through a common synthetic route, using 1-chloro-2-hydrazinoquinoxaline and an appropriate aldehyde. Cyclization is ensured by an oxidation-reduction mechanism using chloranil. The substituents on positions 1 and 8 were chosen based on previous structure–activity relationship (SAR) studies conducted within our heterocyclic Imiqualine family. Physicochemical parameters of all compounds have also been predicted. A375 melanoma cell line viability has been evaluated for 16 compounds. Among them, three novel [1,2,4]triazolo[4,3-a]quinoxalines display cytotoxic activities. Compounds 16a and 16b demonstrate relative activities in the micromolar range (respectively, 3158 nM and 3527 nM). Compound 17a shows the best EC50 of the novel series (365 nM), even if EAPB02303 remains the lead of the entire Imiqualine family (3 nM).
Approach to Pyrido[2,1-b][1,3]benzothiazol-1-ones via In Situ Generation of Acyl(1,3-benzothiazol-2-yl)ketenes by Thermolysis of Pyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones
Authors: Lystsova Ekaterina A. , Novikov Alexander S. , Dmitriev Maksim V. , Maslivets Andrey N. , Khramtsova Ekaterina E.
Published: July 2023

Acyl(imidoyl)ketenes are highly reactive heterocumulenes that enable diversity-oriented synthesis of various drug-like heterocycles. Such ketenes, bearing heterocyclic substituents, afford angularly fused pyridin-2(1H)-ones in their [4+2]-cyclodimerization reactions. We have utilized this property for the development of a new synthetic approach to pharmaceutically interesting pyrido[2,1-b][1,3]benzothiazol-1-ones via the [4+2]-cyclodimerization of acyl(1,3-benzothiazol-2-yl)ketenes generated in situ. The thermal behaviors of 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones and 3-benzoylpyrrolo[2,1-b][1,3]benzothiazole-1,2-dione (two new types of [e]-fused 1H-pyrrole-2,3-diones reported by us recently) have been studied by thermal analysis and HPLC to elucidate their capability to be a source of acyl(1,3-benzothiazol-2-yl)ketenes. As a result, we have found that only 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones are suitable for this. The experimental results are supplemented with computational studies that demonstrate that thermolysis of 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones proceeds through an unprecedented cascade of two thermal decarbonylations. Based on these studies, we discovered a novel mode of thermal transformation of [e]-fused 1H-pyrrole-2,3-diones and developed a new pot, atom, and step economic synthetic approach to pyrido[2,1-b][1,3]benzothiazol-1-ones. The synthesized drug-like pyrido[2,1-b][1,3]benzothiazol-1-ones are of interest to pharmaceutics, since their close analogs show significant antiviral activity.
Investigation of Oceanic Turbulence Random Phase Screen Generation Methods for UWOC
Authors: Jiang Ruixian , Wang Kexin , Tang Xinke , Wang Xu
Published: July 2023

Underwater wireless optical communication (UWOC) has recently gained great research interest due to its capability of transmitting data underwater with high data rate and low latency. However, oceanic turbulence seriously degrades the optical signal quality and hence the performance of practical UWOC systems. Establishing more accurate and efficient phase screen models is in demand for studying the oceanic turbulence effect. In this paper, techniques for generating underwater random phase screens are studied and supplemented. A promising hybrid method combining sparse spectrum and Zernike polynomials methods is proposed and investigated, which generates phase screens with improved accuracy and efficiency.
Catalytic Ozonation of Reactive Red 195 in Aqueous Solution over a Cobalt/Aluminum Oxide-Ceria Catalyst
Authors: Lv Bi-Hong , Liu Xiao-Yu , Zhou Zhuo-Ming , Jing Guo-Hua
Published: July 2023

The textile industry has become one of the largest producers of water pollution. The azo dyes used in the textile industry may present a serious environmental problem because of their high toxicity and chemical stability. In the present work, the cobalt/aluminum oxide-ceria (Co/Al2O3-CeO2) catalyst was synthesized, and the degradation of Reactive Red 195 (RR195) by catalytic ozonation was studied. The Co/Al2O3-CeO2 catalyst was synthesized via the incipient wetness method with the assistance of ultrasound. The presence of Co/Al2O3-CeO2 did not notably improve the degradation of RR195 compared to ozonation alone, but it was advantageous for RR195 mineralization. The effects of initial dye concentration (200–800 mg/L), catalyst dosage (1–4 g/L), and solution pH (4–10) on color, and COD removal were evaluated. The results indicate that the dye’s concentration significantly affects COD removal efficiency. The optimum catalyst dosage and pH values were determined to be 3 g/L and 8, respectively. Co/Al2O3-CeO2 catalyst shows good catalytic activity and stability based on four repeated tests during RR195 ozonation. Finally, a possible mechanism and a kinetic scheme of the catalytic ozonation of RR195 were proposed.
Removal of Paracetamol and Cu2+ from Water by Using Porous Carbons Derived from Agrowastes
Authors: Ferreira Regiane C. , de Araújo Thiago Peixoto , Dias Diogo , Bernardo Maria , Lapa Nuno , Fonseca Isabel M. , de Barros Maria A. S. D.
Published: July 2023

Dende and babassu coconuts are largely used in tropical countries, namely in Brazil, for the extraction of oils from kernels. The remaining biowastes are industrially processed to produce porous carbons (PCs). PCs derived from dende and babassu biowastes and produced at an industrial scale have been characterized by textural, chemical, and ecotoxicological parameters. A commercial activated carbon (CC) of mineral origin has been used as a benchmarking material. Although the CC sample presented a higher surface area (SBET = 1083 m2/g), the PCs derived from the biowastes were richer in micropores (Vmicro = 0.25–0.26 cm3/g), while the CC carbon presented wider pore size distribution with a higher mesopore volume (Vmeso = 0.41 cm3/g). All the adsorbents used in this work have shown a non-acute ecotoxic behavior for the bacterium Vibrio fischeri (EC50-30 min > 99% v/v). The adsorbents have been tested for paracetamol and Cu2+ adsorption in mono- and bicomponent solutions. The uptake capacities of paracetamol (qe, 98–123 mg g−1) and Cu2+ (qe, 15–18 mg g−1) from monocomponent solutions were similar to the ones obtained in the bicomponent solutions, indicating no competition or cooperative effects but a site-specific adsorption. This finding represents an advantage for the removal of these adsorbates when present in the same solution as they can be adsorbed under similar rates as in the single systems. Paracetamol adsorption was related to micropore filling, π-π interactions, and H-bonding, whereas Cu2+ removal was attributed to the cation exchange mechanism and complexation to the hydroxyl groups at the carbons’ surface.
Study on Residual Oil Distribution Law during the Depletion Production and Water Flooding Stages in the Fault-Karst Carbonate Reservoirs
Authors: Tang Bochao , Ren Ke , Lu Haitao , Li Chenggang , Geng Chunying , Wei Linshan , Chai Zhenhan , Wu Shouya
Published: July 2023

The fault-karst carbonate reservoir is a new type of deep carbonate oil and gas resource and a target for exploration and development. The distribution of remaining oil in this kind of oilfield is very complicated because of its unique reservoir characteristics of vertical migration and accumulation, segmented accumulation, and differential accumulation. Therefore, the S91 reservoir block, a typical fracture-vuggy carbonate reservoir in the Tahe oilfield, was taken as the object of this research. According to the development characteristics as well as the porosity and permeability characteristics of the fracture-vuggy, the reservoirs were divided into three types: cave, pore, and fracture. A numerical simulation model of the fracture-vuggy reservoir of the S91 unit was established, and the historical fitting accuracy with dynamic production data was more than 90%. Then, the distribution characteristics of the remaining oil in the depletion stage of the fault-karst carbonate reservoir were further studied and based on the analysis of the reservoir water-flood flow line, the remaining oil distribution characteristics in the depletion stage of the fault solution reservoir were revealed. The results show that the remaining oil distribution patterns during the depletion production stage can be divided into three types: attic type, bottom water coning type, bottom water running type. Due to the serious problem of the bottom aquifer lifting caused by the reservoir development, the residual oil between wells was relatively abundant during the depletion production stage. According to the simulation results, the remaining oil distribution modes in the water drive development stage were identified as three types: sweeping the middle between wells, bottom water connection and circulation, and oil separation through high-permeability channels. In addition, the reservoir connectivity was the main controlling factor for the remaining oil distribution in the fault-karst carbonate reservoir.
Duração do desemprego no Brasil metropolitano: uma análise através de regressão quantílica censurada
Authors: Campêlo Ana Katarina
Published: July 2023

Conforme enfatizado por Chaudhuri, Doksum e Samarov (1997), o vetor  de regressão quantílica é “um conceito unificador que representa os vetores de coeficientes nos modelos linear, de Cox, de razões proporcionais, de tempo de falha acelerado e assim por diante”. Ademais, considerar-se-á as vantagens até o presente da técnica de regressão quantílica através da estimação destes modelos para fins comparativos com o efeito quantílico de tratamento derivado do modelo de riscos proporcionais de Cox. Estas modelagens são ilustradas numa primeira instância neste trabalho através de aplicação empírica a dados de duração de desemprego no Brasil, fornecendo evidências atuais e no âmbito nacional e possibilitando um estudo mais detalhado e amplo da relação entre as variáveis do modelo, na medida em que esta abordagem permite que as covariáveis impactem de forma bastante flexível no que se refere não só a locação, mas a escala e forma da distribuição condicional. Os resultados econométricos revelam que o fator idade é irrelevante para a duração do desemprego, enquanto que esta é menor em todos os quantis para pessoas que já trabalharam antes, bem como para os indivíduos que possuem qualquer diploma, destacadamente aqueles que têm pós-graduação. Esta última conclusão difere de trabalhos anteriores, que sugerem um efeito médio positivo para anos de educação. Além disso, o tempo na situação de desemprego tende a ser maior em todos os setores de atividades considerados, relativamente a outros de menor representatividade no mercado de trabalho e serviços domésticos. Em adição, outro resultado interessante é o fato de a duração tender a ser mais curta para os indivíduos que residem nas regiões metropolitanas de Recife, Belo Horizonte e Porto Alegre, em comparação com aqueles que moram em Salvador, Rio de Janeiro e São Paulo. Finalmente, é também digno de nota que as estimativas dos efeitos do indicador de chefe de família e de outras dummies relativas ao emprego anterior, como as que indicam se a pessoa foi demitida ou trabalhava no setor formal, além de anos de experiência, são estatisticamente não significativos ao longo de todos os quantis da distribuição condicional da duração do desemprego, de forma distinta ao encontrado em estudos prévios.
Operating costs and their incidence on the marketing of vehicles of chinese origin in dealers in the city of Portoviejo - Ecuador
Authors: Zambrano Juan Carlos Molina , Mendoza Washington Ricardo Rodríguez
Published: July 2023

En la actualidad el planeta está atravesando por una crisis, y aun así el país asiático ha seguido creciendo a nivel de marcas de automóviles, con modelos que ofrecen un buen diseño, calidad, precio y tecnología. “El sistema económico ecuatoriano ha presentado en los últimos años, una serie de movimientos que ha afectado a la población, la cual, en su mayoría se han adaptado, en el sector automotriz esto también se ha evidenciado, tanto en la manufactura como en la importación de los mismos” (Brito, 2022). Por otra parte, las preferencias del mercado ecuatoriano están en constante cambio, debido a que los consumidores están apostando más por los vehículos de origen chino y a su vez incrementando su demanda. “Dentro del mercado automotriz ecuatoriano, ha presentado una tendencia en crecimiento sobre la adquisición de vehículos de origen chino, lo cual, las personas han superado paradigmas” (Morillo & Tatiana, 2022). El objetivo de este articulo es evaluar la incidencia de los costos operativos de la industria automotriz china en la comercialización vehicular de concesionarias del cantón Portoviejo año 2022, y si está condiciona el comportamiento de los clientes al momento de adquirir un vehículo. Para lograr cumplir con el objetivo propuesto se encuesto y entrevisto a los colaboradores y gerentes de las concesionarias de la ciudad de Portoviejo. En el proceso se utilizó técnicas bibliográficas, teóricas, empíricas, y analíticas y por su puesto la observación directa; metodología que proporcionó información que permitió determinar que los clientes potenciales si consideran el origen y precio del vehículo antes de adquirirlo, como también la facilidad de obtener repuestos ante futuros inconvenientes mecánicos. El resultado de la investigación servirá como un análisis para que los gerentes de las concesionarias consideren la importancia de la información proporcionada a los clientes antes de adquirir un automóvil.
A prática da atividade física no presídio: o que pensam os apenados?
Authors: Moraes Adílio Moreira , Moraes Berla Moreira de , Ramos Vanessa Mesquita
Published: July 2023

Trata-se de uma pesquisa exploratório descritiva, com abordagem qualitativa, realizada na Penitenciária Industrial Regional, na cidade de Sobral – Ceará, em que se objetivou identificar o que os apenados pensam sobre a prática da atividade física em sistema penitenciário de segurança máxima. Utilizou-se a entrevista semiestruturada para a coleta das informações. Como participantes da pesquisa, incluíram-se 20 internos que cumpriam pena na referida penitenciária. Na análise do material empírico, utilizou-se a técnica de categorização dos discursos. Os achados da pesquisa apontaram para as categorias: atividade física no presídio, conhecimento sobre regras e fundamentos das modalidades esportivas, comportamento durante a prática de uma atividade física regular e comportamento social dentro do presídio. Os resultados evidenciaram que a prática da atividade física e o esporte são vistos pelos presos como um benefício durante o cumprimento da pena, mas percebe-se que o desconhecimento das regras e fundamentos dos esportes os coloca em desvantagem, podendo repercutir no comportamento inadequado deles durante a prática do desporto.  Espera-se que esta pesquisa possa contribuir de maneira efetiva para que eles consigam conciliar e se adequar às regras e normas vigentes após o cumprimento da pena.
Automatic temperature control system of supply air in the central air conditioner
Authors:   Tokarev A.E.
Published: July 2023

The article is devoted to the development of the system mathematical model for automatic control of the supply air temperature in the summer season in the central air conditioner to ensure a safe and comfortable environment in industrial premises.

Keywords
automatic temperature control system, central air conditioner, transient response, control object, PID controller, control quality index
Теоретичні аспекти планування та управління логістичними системами використання відходів На рівні територіальних громад
Authors: Дзюбинська О.В. , Дзюбинський А.В. , Смаль М.В.
Published: July 2023

Інвестиції в окремі елементи послуг логістики ТПВ без бачення майбутньої системи кругової логістики суттєво не покращать ситуацію із накопиченням сміття. Кругова логістика відходів має характеризуватися високою ефективністю, що потребує належного інформаційного потоку між різними учасниками ланцюга переробки. Це дозволить забезпечити всіх зацікавлених суб’єктів інформацією щодо управління відходами, створити умови для перерозподілу матеріальних потоків, оптимізувати маршрути утилізації тощо.
PARENTING STRESS DENGAN VERBAL ABUSE ORANGTUA PADA SISWA KELAS VIII SMPN 3 CIBINONG
Authors: Rina Afrina  , Emi Yuliza
Published: July 2023

Peningkatan kekerasan khususnya pada anak di tahun 2020 mengakibatkan peningkatan jumlah angka kematian anak dari usia 0 – 17 tahun. Bentuk kekerasan yang paling sering terjadi adalah verbal abuse atau kekerasan dalam bentuk verbal (ucapan/perkataan) kepada individu. Salah satu pelaku kekerasan fisik pada anak adalah orang tua ataupun pengasuh. Salah satu factor penyebab terjadinya verbal abuse adalah parenting stress. Penelitian ini bertujuan untuk mengetahui Hubungan Parenting Stress dengan Verbal Abuse Orangtua pada Siswa Kelas VIII SMPN 3 Cibinong.Penelitian ini menggunakan jenis penelitian kuantitatif dengan jenis penelitian deskripsi korelatif dan dengan desain penelitian menggunakan cross sectional. Jumlah populasi dalam penelitian ini sebany ak 471 siswa kelas

VIII. Perhitungan sampel menggunakan rumus slovin dan teknik pemilihan sampel menggunakan Purposive Sampling sehingga didapatkan sampel sebanyak 213 siswa/i. Analisis bivariat mengunakan uji korelasi Pearson Chi Square. Instrument dalam mengukur Verbal Abuse orangtua adalah kuesioner Korean Version Verbal Abuse Questionnaire (K-VAQ) yang dibuat menjadi 15 pernyataan dalam skala likert dan Parenting Stress dengan 18 item pernyataan dengan skala likert . Hasil penelitian didapatkan bahwa sebanyak 198 siswa mengatakan orangtua berada dalam parenting stress sedang dan sebanyak 189 siswa mengatakan bahwa verbal abuse yang dilakukan orangtua dalam kategori rendah. Dari hasil uji pearson chi square didapatkan adanya hubungan antara parenting s tress dengan verbal abuse orangtua, dengan nilai p< 0,05 (p=0,000). Pencegahan dini verbal abuse orangtua dan penurunan parenting stress dapat dilakukan dengan memberikan edukasi parenting oleh pihak sekolah
Adenocarcinoma de glándulas ceruminosa: reporte de un caso
Authors: Beltrán-Henríquez Juanita María , Valderrama-Penagos Johanna Ximena , Ordóñez-Ordóñez Leonardo Elías , Cortes Ximena
Published: July 2023

El adenocarcinoma de glándula ceruminosa es una neoplasia poco frecuente del conductoauditivo externo; en la literatura se ha descrito únicamente a través de reportesde caso, por lo que no se dispone de consensos ni guías de manejo. Presentamos elcaso de un paciente masculino de 57 años que presenta adenocarcinoma de glándula ceruminosa confirmado por inmunohistoquímica. El tratamiento se basó en el manejo quirúrgico con resección ampliada de la lesión, con lo cual se obtuvieron bordes negativos durante el procedimiento y la consecuente reconstrucción de piel con colgajoen el mismo tiempo quirúrgico.
Anthropological Ecology and Ecological Anthropology as a Framework for the Analysis of Socio-Ecological Sustainable Development
Authors: Vargas-Hernandez José G. , Higuera-Cota María F. , Vargas-González Omar C.
Published: July 2023

This study is aimed at analyzing anthropological ecology and ecological anthropology as a framework approach for the analysis of socio-ecological sustainable development. It departs from the assumption that sustainable development requires a socio-ecological approach sustained by anthropology and ecology. The method used is analytical reflection based on the conceptual, theoretical, and empirical literature review. The study concludes that anthropology and ecology combine elements to sustain the anthropological ecology and ecological anthropology approaches to develop the framework for the analysis of a socio-ecological sustainable development.
Manufacturing of Marketable Energy Sources From Agricultural Crops
Authors: Millan-Tudela Luis A. , Marco-Lajara Bartolomé , Sánchez-García Eduardo , Martínez-Falcó Javier
Published: July 2023

The evolution of societies has been historically linked to the production, consumption and, ultimately, availability of energy. The development of more efficient technologies has led to several energy sources' evolution and change over the past centuries. However, those changes, together with a considerable rise of energy consumption, have also brought a threat to ecosystems in the form of several contaminants. In this chapter, a study on the potential use of crops for producing marketable energy is assessed, using the Spanish agriculture sector as study case given its substantial contribution to crop production in the European Union.
The dorsal root ganglion as a target for neurorestoration in neuropathic pain
Authors: Estivill-Torrús Guillermo , Martínez-Padilla Ana Belen , Sánchez-Salido Lourdes , Evercooren Anne Baron-Van , García-Díaz Beatriz
Published: July 2023

Neuropathic pain is a severe and chronic condition widely found in the general population. The reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in patients. During the processing of pain, the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission and propagation of sensory electrical stimulation. Furthermore, the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understanding of the development and resolution of neuropathic pain and in the elucidation of innovative therapies. Here, we will review the complex interplay between cells (satellite glial cells and inflammatory cells) and factors (cytokines, neurotrophic factors and genetic factors) that takes place within the dorsal root ganglia and accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic pain. More importantly, we will summarize an updated view of the current pharmacologic and nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.
Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke
Authors: Duan Hongmei , Li Shulun , Hao Peng , Hao Fei , Zhao Wen , Gao Yudan , Qiao Hui , Gu Yiming , Lv Yang , Bao Xinjie , Chiu Kin , So Kwok-Fai , Yang Zhaoyang , Li Xiaoguang
Published: July 2023

JOURNAL/nrgr/04.03/01300535-202402000-00035/inline-graphic1/v/2023-07-19T141749Z/r/image-tiff

Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation, differentiation, migration, and survival, as well as angiogenesis, in the context of brain injury. However, whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still unknown. In this study, we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in rats. The gel slowly released basic fibroblast growth factor, which improved the local microenvironment, activated endogenous neural stem/progenitor cells, and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons, while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional recovery. This study revealed the mechanism by which bioactive materials repair ischemic strokes, thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.
The role of exosomes in adult neurogenesis: implications for neurodegenerative diseases
Authors: Yu Zhuoyang , Teng Yan , Yang Jing , Yang Lu
Published: July 2023

Exosomes are cup-shaped extracellular vesicles with a lipid bilayer that is approximately 30 to 200 nm in thickness. Exosomes are widely distributed in a range of body fluids, including urine, blood, milk, and saliva. Exosomes exert biological function by transporting factors between different cells and by regulating biological pathways in recipient cells. As an important form of intercellular communication, exosomes are increasingly being investigated due to their ability to transfer bioactive molecules such as lipids, proteins, mRNAs, and microRNAs between cells, and because they can regulate physiological and pathological processes in the central nervous system. Adult neurogenesis is a multistage process by which new neurons are generated and migrate to be integrated into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two specialized niches: the subventricular zone adjacent to the lateral ventricles and the subgranular zone of the dentate gyrus. An increasing body of evidence indicates that adult neurogenesis is tightly controlled by environmental conditions with the niches. In recent studies, exosomes released from different sources of cells were shown to play an active role in regulating neurogenesis both in vitro and in vivo, thereby participating in the progression of neurodegenerative disorders in patients and in various disease models. Here, we provide a state-of-the-art synopsis of existing research that aimed to identify the diverse components of exosome cargoes and elucidate the therapeutic potential of exosomal contents in the regulation of neurogenesis in several neurodegenerative diseases. We emphasize that exosomal cargoes could serve as a potential biomarker to monitor functional neurogenesis in adults. In addition, exosomes can also be considered as a novel therapeutic approach to treat various neurodegenerative disorders by improving endogenous neurogenesis to mitigate neuronal loss in the central nervous system.
Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy
Authors: Chen Feng , Dong Xi , Wang Zhenhuan , Wu Tongrui , Wei Liangpeng , Li Yuanyuan , Zhang Kai , Ma Zengguang , Tian Chao , Li Jing , Zhao Jingyu , Zhang Wei , Liu Aili , Shen Hui
Published: July 2023

JOURNAL/nrgr/04.03/01300535-202402000-00037/inline-graphic1/v/2023-07-19T141749Z/r/image-tiff

Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory, resistant to antiepileptic drugs, and has a high recurrence rate. The pathogenesis of temporal lobe epilepsy is complex and is not fully understood. Intracellular calcium dynamics have been implicated in temporal lobe epilepsy. However, the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown, and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving mice. In this study, we used a multi-channel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy process. We found that calcium signals varied according to the grade of temporal lobe epilepsy episodes. In particular, cortical spreading depression, which has recently been frequently used to represent the continuously and substantially increased calcium signals, was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from grade II to grade V. However, vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor seizures. Chemogenetic inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to grade I episodes. In addition, the latency of cortical spreading depression was prolonged, and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly reduced. Intriguingly, it was possible to rescue the altered intracellular calcium dynamics. Via simultaneous analysis of calcium signals and epileptic behaviors, we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced, and that the end-point behaviors of temporal lobe epilepsy were improved. Our results indicate that the calcium dynamic between CA1 and M1 may reflect specific epileptic behaviors corresponding to different grades. Furthermore, the selective regulation of abnormal calcium signals in CA1 pyramidal neurons appears to effectively alleviate temporal lobe epilepsy, thereby providing a potential molecular mechanism for a new temporal lobe epilepsy diagnosis and treatment strategy.
Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
Authors: Wang Guixiang , Wang Wenjia , Zhang Ye , Gou Xiaoying , Zhang Qingqing , Huang Yanmiao , Zhang Kuo , Zhang Haotian , Yang Jingyu , Li Yuting
Published: July 2023

JOURNAL/nrgr/04.03/01300535-202402000-00036/inline-graphic1/v/2023-07-19T141749Z/r/image-tiff

Adolescent binge drinking leads to long-lasting disorders of the adult central nervous system, particularly aberrant hippocampal neurogenesis. In this study, we appliedin vivofluorescent tracing usingNestinCreERT2::Rosa26-tdTomatomice and analyzed the endogenous neurogenesis lineage progression of neural stem cells (NSCs) and dendritic spine formation of newborn neurons in the subgranular zone of the dentate gyrus. We found abnormal orientation of tamoxifen-induced tdTomato+(tdTom+) NSCs in adult mice 2 months after treatment with EtOH (5.0 g/kg, i.p.) for 7 consecutive days. EtOH markedly inhibited tdTom+NSCs activation and hippocampal neurogenesis in mouse dentate gyrus from adolescence to adulthood. EtOH (100 mM) also significantly inhibited the proliferation to 39.2% and differentiation of primary NSCsin vitro. Adult mice exposed to EtOH also exhibited marked inhibitions in dendritic spine growth and newborn neuron maturation in the dentate gyrus, which was partially reversed by voluntary running or inhibition of the mammalian target of rapamycin-enhancer of zeste homolog 2 pathway.In vivotracing revealed that EtOH induced abnormal orientation of tdTom+NSCs and spatial misposition defects of newborn neurons, thus causing the disturbance of hippocampal neurogenesis and dendritic spine remodeling in mice.
Salvage surgery in laryngeal cancer after radiotherapy and partial surgery - comparative results
Authors: Miśkiewicz-Orczyk Katarzyna , Ścierski Wojciech , Lisowska Grażyna , Majewski Wojciech , Golusiński Paweł , Misiołek Maciej
Published: July 2023

Objective:

The study is a retrospective comparison of the usefulness of salvage surgery between a group of previously radiotherapy-treated patients (RTPs) and a group of patients who previously underwent partial surgery with both local and ± nodal recurrence.

Study Design:

Retrospective study.

Setting:

Multi-center academic hospital.

Materials and Methods:

The former group was comprised 30 previously RTPs, whereas the latter group consisted of 20 patients after partial laryngeal surgery with optional subsequent adjuvant radiotherapy (PSPs). Treatment efficacy was compared in both groups in relation to overall survival (OS) and the locoregional control rate (LCR). Local and ± nodal recurrence was considered primary treatment failure. All patients underwent total laryngectomy.

Results:

The updated 5-year OS in the PSPs was 31%, while the percentage of the updated 5-year LCR was 42%. In the RTPs the updated 5-year OS was 21%, and the percentage of 5-year LCR was 38%. No statistically significant differences were found in terms of the comparison of OS or the comparison of LCR results in both groups (P = 0.427, P = 0.704, respectively).

Conclusions:

Based on the analysis, it was found that irrespective of the initial treatment, salvage surgery was associated with decreased survival and cure rates (by 50%) compared to the group of patients with advanced laryngeal cancer who underwent primary total laryngectomy.