bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Loneliness in Older Adults with Mild Cognitive Impairment: Predictive Factors and Associated Clinical Characteristics
Authors: Prada Crespo David , Montejo Carrasco Pedro , Díaz-Mardomingo Carmen , Villalba-Mora Elena , Montenegro-Peña Mercedes
Published: December 2023

Background: Loneliness and social isolation are considered public health problems among older individuals. In addition, both increase the risk of developing cognitive impairment and dementia. The Social Loneliness construct has been proposed to refer to these harmful social interaction-related factors. Objective: To define the risk factors of Social Loneliness in individuals with mild cognitive impairment (MCI) and to analyze cognitive, emotional, and functional differences according to the participant’s degree of Social Loneliness. Methods: Through convenience sampling, 105 participants over 60 diagnosed with MCI were selected. The evaluation consisted of anamnesis and a comprehensive neuropsychological examination. The ESTE-II questionnaire was used to assess Social Loneliness and its three factors: perceived social support, social participation, and use of communication technologies. Personality was measured with the NEO-FFI questionnaire. Results: The predictors of the Social Loneliness factors were as follows; 1) perceived social support (R2 = 0.33): Neuroticism (β= 0.353), depression (β= 0.205), and perceived health (β= 0.133); 2) social participation (R2 = 0.24): Conscientiousness (β= –0.344) and Extraversion (β= –0.263); 3) use of communication technologies (R2 = 0.44): age (β= 0.409), type of cohabitation (β= 0.331), cognitive reserve (β= –0.303), and Conscientiousness (β= –0.247); all p < 0.05. The participants with a higher degree of Social Loneliness showed more depressive symptoms (R2 = 0.133), more memory complaints (R2 = 0.086), worse perceived health (R2 = 0.147), lower attentional performance/processing speed (R2 = 0.094), and more naming difficulties (R2 = 0.132); all p < 0.05. Conclusions: This research represents an advance in detecting individuals with MCI and an increased risk of developing Social Loneliness, which influences the configuration of the clinical profile of MCI.
Parental Experiences with Newborn Screening and Gene Replacement Therapy for Spinal Muscular Atrophy
Authors: Meyer Alayne P. , Connolly Anne M. , Vannatta Kathryn , Hacker Natasha , Hatfield Andrea , Decipeda Abigail , Parker Patricia , Willoughby Ava , Waldrop Megan A.
Published: December 2023

Background:

Spinal muscular atrophy (SMA) is a genetic neurodegenerative disorder with onset predominantly in infants and children. In recent years, newborn screening and three treatments, including gene replacement therapy (Onasemnogene abeparvovec-xioi), have become available in the United States, aiding in the diagnosis and treatment of children with SMA.

Objective:

To evaluate parents’ experiences with newborn screening and gene replacement therapy and to explore best practices for positive newborn screen disclosure and counseling of families.

Methods:

We conducted semi-structured interviews ( n = 32) and online surveys ( n = 79) of parents whose children were diagnosed with SMA (on newborn screening or symptomatically) and treated with gene replacement therapy.

Results:

Gene replacement therapy was most parents’ first treatment choice, although concerns regarding long term efficacy (65%) and safety (51%) were common. Information provided during the newborn screening disclosure was quite variable. Only 34% of parents reported the information provided was sufficient and expressed need for more information about treatment. Although many parents experienced denial of the diagnosis at initial disclosure, 94% were in favor of inclusion of SMA on newborn screening. Parents were almost universally anxious following diagnosis and over half remained anxious at the time of study participation with uncertainty of the future being a key concern. Many parents had difficulty processing information provided during their first clinic appointment due to its complexity and their emotional state at the time.

Conclusions:

Utilizing this data, we provide a recommendation for the information provided in newborn screening disclosure, propose adjustments to education and counseling during the first clinic visit, and bring awareness of parents’ mental health difficulties.
Machine Learning-Based Classification of Parkinson’s Disease Patients Using Speech Biomarkers
Authors: Hossain Mohammad Amran , Amenta Francesco
Published: December 2023

Background:

Parkinson’s disease (PD) is the most prevalent neurodegenerative movement disorder and a growing health concern in demographically aging societies. The prevalence of PD among individuals over the age of 60 and 80 years has been reported to range between 1% and 4%. A timely diagnosis of PD is desirable, even though it poses challenges to medical systems.

Objective:

This study aimed to classify PD and healthy controls based on the analysis of voice records at different frequencies using machine learning (ML) algorithms.

Methods:

The voices of 252 individuals aged 33 to 87 years were recorded. Based on the voice record data, ML algorithms can distinguish PD patients and healthy controls. One binary decision variable was associated with 756 instances and 754 attributes. Voice records data were analyzed through supervised ML algorithms and pipelines. A 10-fold cross-validation method was used to validate models.

Results:

In the classification of PD patients, ML models were performed with 84.21 accuracy, 93 precision, 89 Sensitivity, 89 F1-scores, and 87 AUC. The pipeline performance improved to accuracy: 85.09, precision: 92, Sensitivity:91, F1-score: 89, and AUC: 90. The Pipeline methods improved the performance of classifying PD from voice record.

Conclusions:

Our study demonstrated that ML classifiers and pipelines can classify PD patients based on speech biomarkers. It was found that pipelines were more effective at selecting the most relevant features from high-dimensional data and at accurately classifying PD patients and healthy controls. This approach can therefore be used for early diagnosis of initial forms of PD.
Status of carnitine and circulating amino acids and its association with pre-frailty, sarcopenia and diet in an Uruguayan older population
Authors: Moirano Marina , Sgaravatti Aldo , Massa Fernando , Fajardo Gabriela , Riverón Noelia , Sena Geraldine , Simoncelli Mariana , Sanchez Florencia , Guevara Natalia , Vazquez Marta , Maldonado Cecilia
Published: December 2023

BACKGROUND:

Frailty is a clinical-biological syndrome in older adults that carries an increased risk for poor health outcomes. Biomarkers of disability are being studied and some acylcarnitines and amino acids are part of the predictive models.

OBJECTIVE:

To characterize the status of L-carnitine, some acylcarnitines and amino acids and relate them to frailty, sarcopenia and diet in a community-dwelling Uruguayan older population.

METHODS:

Participants were enrolled and assessed through a multi-step process, that included frailty and sarcopenia criteria. L-carnitine, its acyl derivatives and amino acids were determined in blood by LC-MS/MS and dietary intake by a 24-h recall and a food frequency questionnaire.

RESULTS:

Sixty-three older adults were enrolled, and 54 completed the initial assessment. Pre-frailty criteria were fulfilled by 41 participants and frailty only by one. No nutritional indicators of undernutrition were found. Probable sarcopenia was found in 20 cases. Males consumed more total meat and red meat than women. Hexanoylcarnitine levels were higher in pre-frail/frail individuals and in weak ones. Analysis by sex showed a distinct pattern between gender, being significant only for weak females. Methionine also showed some differences between sexes. Weak males presented significantly higher levels of methionine, whereas weak females showed significantly lower ones.

CONCLUSIONS:

No associations were found for diet components and L-carnitine, acylcarnitines and amino acids values, except for the percentage of animal protein that was higher in weak males. The clinical impact of these results needs further investigation.
From prenatal care to spina bifida related mortality: The lifespan is marked by transitions experienced by increasing immigrant and international populations
Authors: Castillo Jonathan , Thibadeau Judy K. , Brei Tim , Castillo Heidi
Published: December 2023

Whether it is for collaboration on folic acid fortification or the standardization of care efforts concerning neurogenic bowel dysfunction, a global forum on neural tube defects related issues is needed. Propitiously, the 2023 Spina Bifida World Congress sponsored by the Spina Bifida Association (SBA) was a catalyst for transnational dialog in the field of spina bifida (SB) research. Concurrently, the Journal of Pediatric Rehabilitation Medicine (JPRM) provides a platform for both international research as well as numerous clinical and educational projects, such as The Lifespan Bowel Management Protocol, and social interventions taught through the American Academy of Pediatrics’ Spina Bifida Transition ECHO. Through this open access issue, work by colleagues in Ethiopia, the Nordic countries, and Switzerland, as well as among other transnational populations is highlighted. The development of the Spina Bifida Global Learning Collaborative is also showcased, representing a training initiative across four continents. Correspondingly in this issue, JPRM published an update to the Transition Guidelines for the Care of People with Spina Bifida. The clinical guidelines are a product of the SBA Collaborative Care Network cooperative agreement with the National Center on Birth Defects and Developmental Disabilities in the Centers for Disease Control and Prevention. While colleagues across the globe remain committed to native, immigrant, and displaced populations of individuals affected by SB, JPRM will continue to distribute premier research in multidisciplinary care, education, and advocacy.
To the question of improving the wear resistance of high manganese steel castings
Authors: Kalyaskin A. V. , Bakin I. V. , Kulakov B. A. , Antip’ev A. A.
Published: December 2023

Nowadays, one of the most significant tasks in production of equipment for mining industry is import substitution. In this regard, investigations aimed at improving the technologies of manufacturing high quality castings from wear resistance manganese austenitic steels seems to be relevant. The results of metallographic research of high manganese steel samples from foundries producing crushing plates and crushing cones, track links, hammers, shovel teeth, tooth caps etc. are given. Analysis of the microstructure of the presented castings showed that they are characterized by a coarse-grained structure with an austenite grain size of 1–2 points. In most cases, a thickened grain boundary, presence of manganese carbides along the grain boundaries and non-metallic inclusions are observed. The revealed mi-crostructure features of castings are one of the main indicators of low wear resistance of high manganese steel parts. The operational and technological factors affecting the wear resistance of castings are listed. Recommendations for improving the quality of steel products made from manganese steels are proposed, and the results of using original complex modifiers developed at NPP Technology Company in real manufacturing conditions are presented.
Expanding the technological capabilities of the twin roll casting machine.
Authors: Protasov A. V. , Sivak B. A., , Yakimanskii A. M.
Published: December 2023

urrently, one of the most promising areas of metallurgy development is the creation of foundry and rolling complexes based on twin roll casting machines. Their application makes it possible to organize the economical production of high-quality strips of stainless and alloy steels for critical purposes. Despite the existing experience in the creation and development of such equipment in Russia, domestic developments are still inferior to the foreign level. Thus, there is an urgent need to continue work on this topic and to create domestic industrial equipment, taking into account the latest technical solutions. At the same time, the technological capabilities of twin-roll casting machines both here and abroad are not fully used. The specialists of JSC AHK VNIIMETMASH have developed a number of the latest versions of the twin-roller casting machine with advanced technological capabilities. Due to the dosed supply of various reagents into the gap between the casting rolls-crystallizers it is possible to produce steel strips with improved properties, as well as porous aluminium strips, and also composite strips for critical applications. The article discusses the design and technological features of the proposed options for two-roller casting machines.
Structures of bored piles: features of installation technology
Authors: Havryliuk Oleksandr , Zhuk Veronika , Dyptan Tetiana
Published: December 2023

Currently, pile foundations are often used in engineering practice. Among the modern types of piles used for foundation structures, the option of foundations made of bored piles is definitely popular. They are used for various types of structures: bridges as part of highways, urban ring roads or high-rise buildings. The main problem in these cases is related to a reliable assessment of the bearing capacity of the pile and the development of a cost-effective design solution for foundation structures.

The studies carried out in this direction confirm that the issue of determining the load-bearing capacity of piles remains relevant both at the stage of developing reliable design solutions and in the process of searching for an economically efficient option of the foundation constructions of buildings and structures.

Taking into account the design features of bored piles and their installation technology add certain difficulties to the analytical methods of determining the soil bearing capacity of a single pile.

The practice of using bored piles on construction sites followed by observation of deformations showed that the soil bearing capacity of the piles, determined by the analytical method of standards used at the stage of developing design solutions for foundations, is underestimated. Therefore, the total number of piles in the foundation needs to be optimized according to the results of further field tests. Geometric parameters of piles, such as length and diameter, in some cases can also be reduced at the stage of rationalization of the design solution of the pile foundation, based on the results of field tests. So, as a result, the underestimated value of the load-bearing capacity of bored piles causes an increase in the cost of construction materials, an increase in the cost of installing foundation structures and an increase in the cost of housing for the end consumer.

The problem of reliable assessment of the soil bearing capacity of piles remains a relevant issue at the moment, as evidenced by the practice of designing foundation structures.

The paper presents the results of the analysis of the structural features of bored piles, which are aimed at increasing their bearing capacity. Also, the paper examines the features of the technology of installing bored piles, which are determined by both the hydro-geological conditions of the construction site and the need to install the constructive features of the bored pile.
ALGORITHMS FOR OBTAINING A RESIDENCE PERMIT AND PURCHASING REAL ESTATE FOR UKRAINIANS UNDER SPECIAL MARTIAL LAW CONDITIONS
Authors: Kulikovska Olha , Stupen Roman , Kovalyshyn Oleksandra , Ryzhok Zorian
Published: December 2023

Approximately a quarter of the surveyed Ukrainian refugees and IDPs said that they plan to stay in their new places of residence, in the countries of their choice, obtain a residence permit, and purchase real estate. The legislation of Ukraine, like that of other countries, provides that ownership and other real rights to real estate, encumbrances, as well as their creation, transfer and termination, are subject to state registration. Rights to real estate subject to state registration arise from the moment of such registration. In essence, state registration is the fact of public recognition by the state of a person's right to real estate by entering information about it into the State Register of Real Property Rights. However, each country has its own regulatory requirements. Therefore, research into real estate registration procedures and algorithms for obtaining a residence permit is relevant. The study is aimed at identifying the peculiarities and algorithms for obtaining a permanent or temporary residence permit by investing in real estate or business in the country of study. real estate registration for Ukrainian citizens who went abroad during the military operations and intend not to return home but to integrate into other countries. The research objects are 9 countries of the world, namely: Turkey, Greece, Montenegro, the United Kingdom, Cyprus, the United Arab Emirates, the United States, Portugal, and Hungary. These countries are characterized by: attractiveness in terms of residence, democratic development, improvement of the quality of service provision and strengthening of trust in the government by the population, the public and the private sector. The information base of the study was based on collections of scientific papers, periodicals, and Internet resources. Summarizing the results of the study, we have constructed a diagram of the cost of investment real estate for permanent residence for the selected countries. The largest investment is required in the UK, while Montenegro has no requirements for real estate investment at all. 

It is determined that the procedure for obtaining the right to temporary or permanent residence through investment and registration of real estate may vary, and the package of documents required for registration also differs depending on the specific object and the circumstances of the rights to it. However, there are simple general recommendations that can help protect real estate rights and save time and money: compliance with the country's legislation; creation and proper operation of a unified registration system. This analysis will help to identify ways to implement foreign experience in Ukraine's activities in the future. The practical content is indicated by the target orientation of this study for Ukrainian citizens who are forced to stay abroad, urban planning and cadastre specialists.
Kant, Rousseau e a modernidade
Authors: Costa Lorena da Silva Bulhões
Published: December 2023

O presente trabalho tem por tema as filosofias de Kant e Rousseau, mas especificamente como essas duas formas de pensamento se relacionam com o contexto de revolução nas quais estavam inseridas. O questionamento principal do trabalho perpassa pela compreensão do contexto dessas filosofias, considerando a amplitude do movimento Iluminista na modernidade. Por isso, por mais que sejam semelhantes, Kant e Rousseau não partem da mesma visão sobre o Estado não chegando, portanto, ao mesmo resultado. O trabalho começa por expor a forma como o mundo ocidental transitou do medievo para a Idade Moderna, para então apresentar a forma como Rousseau formulou seu contratualismo. Em seguida, a mesma teoria é apresentada, mas a partir de Kant, considerando as particularidades desse autor. O trabalho conclui com um último tópico comparando os dois autores, destacando os afastamentos entre ambos, considerando seu contexto de pensamento.
The Anthropology of the Ukrainian avant-garde within artistic discourse
Authors: Lymar Anna
Published: December 2023

The purpose of the article is to highlight the anthropological essence of avant-garde art in the context of the development of art discourse on the social role of art. Methodology. The purpose of the study was revealed based on the application of interdisciplinarity, systematic, and integrated approaches, as well as the method of art. The use of these methods of research contributed to obtaining their own results. The scientific novelty of the results obtained is to formulate and develop a topical theme of the anthropic art of the avant-garde, which is increasingly recognized in the scientific dimension. The avant-garde witnessed a change in the anthropological context in art and strengthened the role of man in the perception of the author's conception of the artist, concealed in the form and color of the artistic image. Conclusions. The humanist theory of today states that art is concentrated in the eyes of the viewer and the vanguard was the beginning of such an interpretation of the cultural and artistic process. Created by avant-garde artists, the creative potential of forms, goals, and concepts continues to influence the development of art and various art forms in many of its forms – choreography, architecture, and even in fashion and design.
PENINGKATAN SKILL EDITING FOTO & VIDEO MELALUI PELATIHAN PENGENALAN APLIKASI EDITING PADA SISWA KELAS X
Authors: Muflikhun Muhammad Naufal , Febrianto Rian , Syailendra Dwimas , Wibawa Bimantara Bakti , Setiawan Aria Nanda , Rahmah Hilda
Published: December 2023

The increasing demand from companies and the need for job vacancies in the field of photo and video editing in the media today has made it urgent for students majoring in broadcasting to hone their editing skills before jumping in and getting involved in the media industry. Based on observations, the limited human resources available in schools often prevent students from realizing the importance of these skills, so in order to accelerate knowledge, cooperation, and participation of students is needed to improve photo and video editing skills beyond those provided by the school. This community service aims to improve photo and video editing skills through training in the introduction of Adobe Photoshop and Adobe Premiere editing applications, for class X students majoring in Broadcasting at SMKN 1 Demak. The method used in this activity is Participatory Action Research (PAR), with stages, namely, observation, planning, action, and evaluation. The training includes an introduction to several photo and video editing applications, Adobe Photoshop and Adobe Premiere, as well as effective editing techniques. The results of this activity obtained a percentage increase in knowledge about photo and video editing skills of 82.7%. High student enthusiasm also shows an increase in theoretical understanding of how to edit photos and videos. This training has helped students apply photo and video editing skills in terms of promotions, digital marketing, company profiles, and personal branding of a product. Furthermore, this skill also opens up opportunities for students to be able to create businesses independently in the field of creating strategies and creative content.
Novel co-occurrence of hypophosphatemic rickets with 46XY DSD (disorder of sex development) due to a CYP17A1 variant
Authors: A Mondkar Shruti , Yewale Sushil , Khadilkar Vaman , Khadilkar Anuradha
Published: December 2023

17-α-hydroxylase deficiency causes a rare type of congenital adrenal hyperplasia (CAH). X-linked hypophosphatemic rickets (XLH) is a rare disorder caused by inactivating mutations in the PHEX gene. We report a novel co-occurrence of XLH with 46XY disorder of sex development due to 17-α-hydroxylase deficiency. A young child reared as a girl, presented as a toddler with genu varus, low phosphorus, normal calcium, and parathormone, and was treated as hypophosphatemic rickets. In early childhood, due to short stature and hypertension, the child was investigated for Turner syndrome. Ultrasound revealed intra-abdominal gonads and an absent uterus. The karyotype was 46XY. Investigations revealed low serum cortisol, renin, normal 17-hydroxyprogesterone, and aldosterone. A year later, a bilateral orchidectomy was performed. Two years later, she was referred to us for further management. Adrenocorticotrophic hormone (ACTH), cortisol, renin, deoxycorticosterone, and clinical exome were advised. She was lost to follow-up for 3 years. On follow-up in early adolescence, she was pre-pubertal; biochemical findings of hypophosphatemic rickets, elevated ACTH, low cortisol, and low normal aldosterone were noted. Clinical exome revealed variants in the CYP17A1 gene (homozygous) causing CAH (17-α-hydroxylase) and PHEX (hemizygous) gene causing XLH. Treatment with hydrocortisone, phosphate, cholecalciferol, and calcitriol was commenced. Hypertension is now well-controlled, but genu varus persists and may require surgical correction.
Association of DGAT1 with goat milk and meat production traits
Authors: Kravchenko O. , Karban Y.
Published: December 2023

Genetic factors can influence the composition of milk fat and its genetic variation. The purpose of our work was to familiarize and study the structure, role, and influence of the DGAT1 (or diacylglycerol-O-acyltransferase 1) gene on goat milk production, its structure, and relationship with milk fat for further research in improving the goat selection system. The selection of goats, aimed at increasing the frequency of alleles with a positive effect on this trait, was initiated by geneticists. In general, identifying and evaluating genetic markers for milk performance traits are the initial and crucial steps for establishing a marker-assisted selection system (MAS). Thus, increasing productivity through genetic selection is a common goal for many animal breeding programs worldwide. The amount of milk, milk fat, and proteins are essential features of dairy farming. In cheese production, milk fatty acids perform a crucial technical function, as they are the main building blocks of milk fat, giving the cheese its unique taste and textural properties. Milk fatty acids are necessary for producing many dairy products, while intramuscular fat is associated with meat quality. Triacylglycerols (TAG) are the main components of intramuscular fat and milk fat. Therefore, understanding polymorphisms and genes related to fat synthesis is essential for animal husbandry. The identification of quantitative trait loci (QTL) and genes associated with milk production traits has been supported by various studies over the past decade. It was established that QTL genes on chromosomes 14, 15, and 9 are related to the properties of milk and meat production in goats. The presence of the diacylglycerol-O-acyltransferase 1 (DGAT1) gene in goat chromosomes 14, 15, and 9 has been reported. Having a key role in fat metabolism and TAG synthesis, DGAT1 genes have attracted considerable attention, especially in animal milk production. Several polymorphisms have been documented in DGAT1 in different animal species, including many cattle and small cattle, for their association with milk production traits. The critical role of the DGAT1 gene in milk fat metabolism makes it an exciting candidate for genetic variation in milk characteristics in dairy goats.
The evolution of the medicine course at the Institute of Health and Biotechnology of the Federal University of Amazonas in the municipality of Coari/AM, and its current implementation status
Authors: Malosso Milena Gaion , Supravida Keila Abreu , Lima Paula Andreza Viana , Guilherme Adriano Pereira , Santos Ivan Monteiro dos , Leônidas Lilian Vieira , Farias Fleming Nabeshima de
Published: December 2023

The implementation of the medicine course in Coari-AM is a recent achievement for the city and the entire Middle Solimões region, crucial to addressing the shortage of doctors in the Northern Region, which has an average of about 1.4 doctors per thousand inhabitants across all its states, representing some of the worst indicators in Brazil. Thus, aiming to understand the history of the implementation of the medicine course at the Institute of Health and Biotechnology (ISB) in Coari at the Federal University of Amazonas (UFAM) and the current state of implementation, the objective of this work was to report the historical facts about the implementation of this course based on a substantiated analysis of the current work reality offered to the medical faculty involved. For this purpose, the perspectives of the faculty who worked on the implementation of the course were investigated, the causes leading to the attrition of medical professionals from the ISB were diagnosed, and measures were proposed to retain these professionals in this Institute. This work is justified because conducting a historical survey of the implementation of the medicine course at the ISB in Coari is necessary to obtain an accurate diagnosis of the current causes of attrition among faculty in this medical undergraduate program. As a result, it was found that for the purpose of implementing the course, only one building was constructed, but it was not equipped. There was institutional failure in developing a job profile for the hiring of faculty for this course, so only twelve professors with a medical background were hired. The same happened with administrative staff, so there are only two permanent employees specifically supporting this course.
SUSTAINABILITY REPORTING STANDARDIZATION AS A PREREQUISITE FOR GREEN POST-WAR RECONSTRUCTION OF THE AGRICULTURAL SECTOR
Authors: Метелиця Володимир
Published: December 2023

The article is devoted to the study of standardization of sustainable development reporting in the context of granting Ukraine the status of a candidate for membership in the European Union and crisis phenomena related to Russian military aggression against Ukraine. It has been established that the implementation of Directives, Regulations, EU standards in the field of non-financial reporting determines the need for the formation of domestic legislation based on the principles of green transition and digital transformation. It was justified that the Report on Sustainable Development (Environmental, Social, Governance) and Investments (ESGI Report) should become one of the tools for attracting investments, loans, and insurance products in the post-war reconstruction of Ukraine's agricultural sector, taking into account global efforts aimed at preventing negative climate change and global warming.
ГЛОБАЛЬНА ЗОВНІШНЬОЕКОНОМІЧНА ДІЯЛЬНІСТЬ УКРАЇНИ У СВІТОВИХ РЕЙТИНГАХ
Authors: Думанська Катерина , Фeдоришина Лариса
Published: December 2023

Стаття присвячена результатам дослідження глобальних світових покажчиків рівню розвитку країни. У статті сформульовано типологію глобальних індексів за двома напрямами, а саме: згідно способів розрахунку індикаторів і за напрямами глобалізації. Згідно сформованого методологічного базису за типологіями глобальних індексів авторами проаналізовано та синтезовано рейтингові позиції України в глобальних рейтингах і виявлено тенденції стратегізованого розвитку країни в контексті глобального простору. Згідно методології рейтингових оцінок у роботах авторів було проаналізовано більше 20-ти успішних машинобудівних компаній України та виявлено їх потенційні можливості стратегічного розвитку. Дослідження результатів причинно-наслідкового ланцюжка формування основних теорій виникнення, функціонування та розвитку компаній в глобальному середовищі показало особливості їх впливу на створення транснаціональних корпорацій з урахуванням факторів глобалізації економічних процесів, що розкриває історичні причини та визначає сучасні тенденції розвитку глобальних корпоративних утворень.
РЕАБІЛІТАЦІЯ ХВОРИХ ІЗ ХРОНІЧНОЮ СЕРЦЕВОЮ НЕДОСТАТНІСТЮ НА ТЛІ МЕТАБОЛІЧНОГО СИНДРОМУ
Authors: Рогаля Ю. Л. , Куртяк І. Б.
Published: December 2023

Мета дослідження – вивчити вплив комплексної програми фізичної реабілітації на стан хворих з поєднанням хронічної серцевої недостатності та метаболічного синдрому. З метою вивчення взаємозв’язку між показниками, що характеризують хронічну серцеву недостатність (функціональний клас, тест шестихвилинної ходьби, шкала Борга), і компонентами метаболічного синдрому (окружність талії, індекс маси тіла, артеріальний тиск, тригліцериди, холестерин) було проведено дослідження двох груп хворих: перша група (експериментальна) – хворі на хронічну серцеву недостатність без метаболічного синдрому, друга група (контрольна) – хворі на хронічну серцеву недостатність із метаболічним синдромом. Методика занять фізичними вправами залежить від стадії захворювання, ступеню недостатності кровообігу, стану вінцевого кровопостачання. За важких проявів захворювання, вираженої серцевої недостатності або вінцевого кровообігу заняття буду- ються так, щоб передусім надати терапевтичну дію: попередити ускладнення за рахунок поліпшення периферійного кровообігу і дихання, компенсувати ослаблену функцію серця завдяки активізації позасерцевих чинників кровообігу, поліпшити трофічні процеси, стимулювати кровопостачання міокарду. Для цього використовувалися фізичні вправи малої інтенсивності, в повільному темпі для дрібних м’язових груп, дихальні вправи і вправи на розслаблення м’язів. Результати обстеження наприкінці дослідження засвідчили сприятливий вплив запропонованої програми реабілітації на толерантність до фізичних навантажень і, як наслідок, на якість життя. На тлі фізичної реабілітації в дослідженні отримано також позитивну динаміку показників ліпідного профілю у хворих експериментальної групи. Застосування у хворих на хронічну серцеву недостатність комплексної програми фізичної реабілітації, що включає елементи навчання хворих, адаптованої з урахуванням метаболічного синдрому, сприяє підвищенню клінічної ефективності відновної терапії та профілактиці прогресування хронічної серцевої недостатності, а також корекції компонентів метаболічного синдрому та підвищенню якості життя таких пацієнтів.
ДИНАМІКА РІВНЯ РИЗИКУ ПАДІНЬ ПАЦІЄНТІВ ПОХИЛОГО ВІКУ ПІСЛЯ ЛАПАРОСКОПІЧНОЇ ХОЛЕЦИСТЕКТОМІЇ НА ПІДГОСТРОМУ ЕТАПІ РЕАБІЛІТАЦІЇ
Authors: Голод Н. Р.
Published: December 2023

Мета статті полягає у визначенні динаміки ризику падінь пацієнтів похилого віку після лапароскопічної холецистектомії (ЛХЦ) у підгострому періоді реабілітації під впливом засобів фізичної терапії. Матеріал. 80 пацієнтів похилого віку віком від 60 до 74 років із хронічним калькульозним холециститом (ХКХ) (n = 40) із яких жінки (n = 31), чоловіки (n = 9), та пацієнтів із гострим калькульозним холециститом (ГКХ) (n = 40), із яких жінки (n = 31) і чоловіки (n = 9), після ЛХЦ. Дослідження рандомізоване, просте, з одиночним засліпленням. Пацієнти із ХКХ: основна група (ОГ1), контрольна група (КГ1); із ГКХ: ОГ2 та КГ2. Пацієнти ОГ1 і ОГ2 отримували реабілітаційне втручання на підгострому етапі реабілітації зі стратегією зниження ризику падінь. Методи. Тест Берга на рівновагу. Методи математичної статистики: використовували t-критерій Стьюдента для залежних та незалежних вибірок, рівень значимості: p < 0,05. Результати. Ризиком падінь за тестом Берга вважається результат менше 40 балів, пацієнти похилого віку після ЛХЦ усіх груп у підгострому періоді мали ризик падіння. Під час першого обстеження рівня рівноваги не встановлено статистично значущої різниці між групами, у тому числі між групами із ХКХ і ГКХ. Порівняльна характеристика результатів тестування груп до та після реабілітації встановила статистично значущу різницю під час порівняння груп КГ1 і ОГ1 після; КГ2 і ОГ2 після та під час порівняння результатів ОГ1 до і ОГ1 після; ОГ2 до і ОГ2 після проведеного реабілітаційного втручання, що свідчить про ефективність впровадженої стратегії та засобів зниження ризику падінь. Висновки. Пацієнти похилого віку після ЛХЦ усіх груп на початку підгострого етапу реабілітації мали ризик падінь. Пацієнти контрольних груп (КГ1 і КГ2), які мали медикаментозну підтримку, відповідні дієтичні настанови та рекомендації щодо рухового режиму, не покращили свою функцію рівноваги за 12 тижнів. Результати рівноваги пацієнтів ОГ1 і ОГ2 які отримали реабілітаційне втручання зі стратегією зниження падінь і займалися за програмою фізичної терапії тривалістю 12 тижнів (36 занять), продемонстрували вихід із зони ризику падінь та статистично значуще (р < 0,05) підвищення результатів.
ПОРІВНЯЛЬНА ОЦІНКА ЕФЕКТИВНОСТІ ТРАДИЦІЙНИХ МЕТОДИК ФІЗИЧНОЇ ТЕРАПІЇ КОКСАРТРОЗУ 2–3 СТУПЕНЯ ТА ПОЄДНАННЯ МЕТОДИК НЕУРАК ТА МАЛЛІГАН
Authors: Гришин І. Л. , Антонова-Рафі Ю. В.
Published: December 2023

Мета. Дослідження спрямоване на виявлення найбільш ефективних підходів та рекомендацій до застосування аспектів традиційних програм фізичної терапії в лікуванні коксартрозу 2–3 ступеня з використанням методик Неурак та Малліган, а також їх комбінації. Матеріали та методи. Дослідження проводилися на основі аналізу наукових праць [1–34] та інформативних джерел, що охоплювали дані реабілітаційних центрів міста Києва впродовж 2021–2023 років. Участь у дослідженні взяли 120 хворих (60 чоловіків, 60 жінок) з коксартрозом 2–3 ступеня. Оцінка функціонального стану включала аналіз ходи, амплітуди рухів, функціональних змішаних рухів, інтенсивності болю за шкалою ВАШ та інші показники. Результати. Проводиться аналіз ефективності традиційних програм фізичної терапії в лікуванні коксартрозу 2–3 ступеня з використанням підходів доказової медицини. Розглянуто традиційні програми фізичної терапії, що використовуються для лікування коксартрозу 2–3 ступеня. У статті розглянуто підходи доказової медицини до оцінювання якості досліджень, зокрема рандомізовані контрольовані дослідження та мета-аналізи. Загалом стаття надає важливий огляд ефективності традиційних програм фізичної терапії для лікування коксартрозу 2–3 ступеня на основі доказових даних. Дослідження показали загальну користь методик Неурак та Малліган, а також їх комбінації для фізичної терапії у пацієнтів із коксартрозом 2–3 ступеня. Застосування підходів доказової медицини дало змогу об’єктивно оцінити якість та можливі обмеження реабілітаційних програм. Висновки. Стаття зазначає переваги та обмеження різних традиційних програм фізичної терапії для лікування коксартрозу 2–3 ступеня на основі доказових даних та підкреслює актуальність застосування методик Неурак та Малліган а також їх комбінації. Результати дослідження підкреслюють необхідність враховувати індивідуальні потреби пацієнта та консультуватися з медичними фахівцями під час вибору методики. Огляд сприяє більш обґрунтованому застосуванню традиційних програм фізичної терапії в практиці лікування коксартрозу 2–3 ступеня.
THE ESSENCE AND CONTENT OF STRATEGIC ANALYSIS OF THE ENTERPRISE
Authors:   Vinnytsia Institute University ", Shved Vadym ,   Ukraine", Kanashhuk Vitalij ,   Vinnytsia Institute University "Ukraine"
Published: December 2023

The article analyzes the essence and significance of strategic analysis of an enterprise's activities. It is worth noting that, according to researchers, strategic analysis is the initial stage of development of any strategy and a tool for collecting, analyzing and evaluating a database of internal and external environment in order to identify positive and negative factors and ways to achieve strategic goals and directions of development of the industry. Attention is paid to defining the content of strategic analysis. It is noted that strategic analysis is a starting point for developing a company's strategy and is based on research and evaluation of the internal and external environment. The article provides basic questions illustrating the relationship between the analysis of the environment and its conclusions. In addition, the key issues of strategic analysis of the macro- and micro-environment of an enterprise are identified. Strategic analysis as a function of strategic management forms a set of alternatives for decision-making. Based on the analysis of these tasks, the article provides a scheme of logical transition from the analysis of the micro- and macro-environment of an enterprise to the development of alternatives and selection of the optimal strategy from them. The study presents related tasks that make up the appropriate strategy of an enterprise and visualizes the role of strategic analysis as a tool for choosing an appropriate strategy by an enterprise. In particular, the author determines that the first task is to analyze the macro-environment, which makes it possible to determine the subject of its activities; the second is to determine the goals; the third is to conduct a direct strategic analysis, and the fourth is to implement the strategy. The author emphasizes the place of strategic analysis in the development of strategic management tasks. The author agrees with the thesis that making a strategic choice based on strategic analysis is the basis that "sews" individual business decisions with competitive actions that take into account the current state of the enterprise.
FORMATION OF THE MAIN OBJECTIVES OF INNOVATION POLICY BY PUBLIC AUTHORITIES
Authors:   Prydniprovska State Academy of Civil Engineering and Architecture, Yevseieva Galina , Kakhovych Olena ,   Prydniprovska State Academy of Civil Engineering and Architecture, Kakhovych Yulia ,   University of Customs and Finance
Published: December 2023

The article examines the fact that the primary stabilization, and further growth of the positions of business entities on the world market, is ensured on the basis of the implementation of the results of scientific research and development in the direction of the creation of modern intensive technologies and the manufacture of high-tech products. Solving this issue is important, since attracting capital to increase innovation in the scientific and technical sphere requires the creation of tools that will stimulate the entire process of innovative activity. For this, it is necessary to initiate the participation of institutional bodies of state and local self-government, as well as business structures that will implement innovative projects, form and implement effective innovative development strategies. It has been proven that enterprises that quickly and effectively use innovations not only as isolated processes of point renewal of production, but give the processes of introducing innovations a key place in the development of production activities of industrial enterprises, that is, they will carry out systematic, continuous development of innovative activities, will develop. The main problems and prospects of innovation policy are highlighted. Ukraine's place in the global rankings has been determined, which is a determining indicator and allows to assess the effectiveness of the state's innovation policy implementation. The effectiveness of the implementation of Ukraine's innovation policy was analyzed according to the rating of the Global Innovation Index, the Global Sustainable Competitiveness Index, the Global Talent Competitiveness Index, the Summary Innovation Index the Human Development Index. It was found that the penetration of innovations into all spheres of economy creates their value and provides an effective strategy for the development of industrial enterprises. The importance of solving this issue for the economy of Ukraine is necessary, since the strategy for the development of the national economy is based on an innovative path. It is highlighted that the main strategic task is the introduction of innovations in technological, resource and organizational directions to ensure various directions of updating the company's work and expanding the circle of consumers and business partners on the national and global markets.
FROM FACTORY OF THE WORLD TO ECONOMIC SUPERPOWER: CHINA'S INFLUENCE ON THE GLOBAL ARENA
Authors:   Taras Shevchenko National University, Darid Al-Hayali
Published: December 2023

China's profound transformation into a global economic power has changed the world order, challenging the traditional dominance of Western economies. This article examines the multifaceted dimensions of China's rise and its impact on the international economic system. Over the past three decades, China's economic growth has been impressive, making it the world's second-largest economy by nominal GDP in 2022, behind only the United States. This remarkable journey has seen China's GDP grow more than tenfold since 1978. However, the benefits of this growth have not been shared evenly, with differences in living standards between rural and urban populations and marked social inequality in cities persisting. China's industrial power is second to none, accounting for roughly half of the world's steel, aluminum and cement production. It is a leading producer of major commodities such as coal, manganese, lead-zinc, antimony and tungsten. The country's influence extends to the energy sector with significant oil and gas production. In addition, China's dominance of rare earth metals, critical to modern technology, is almost complete thanks to significant investment since the 1980s. The article highlights China's ambitious ten-year plan, launched in 2015, to modernize its manufacturing capabilities to compete with German rivals and global companies. China's influence extends beyond the economy, with its global presence growing as the largest trading partner of many countries and the leader of the world's largest free trade bloc through RCEP. In addition, the Belt and Road initiative strengthens China's position in Central Asia and Europe. It highlights China's strategic control over the production of green technologies such as solar cells, wind turbines and rare earth elements, underscoring the West's growing dependence on China to meet its environmental goals.
THE ROLE OF RENEWABLE ENERGY SOURCES IN ENSURING ENERGY SECURITY OF UKRAINE
Authors:   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Kuznietsova Kateryna , Bailo Oleksandr ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute»
Published: December 2023

Stable functioning of the energy sector is the path to development and economic growth for any country. In the context of a full-scale military invasion of Ukraine, the issue of ensuring energy stability has become a top priority, as infrastructure facilities in this sector are the main targets of the enemy and the means for its other manipulations. Under current conditions, conventional energy is not able to fully meet the electricity needs of the population and business entities, so the need to develop enterprises that generate electricity from alternative sources comes to the fore. The purpose of this study is to develop effective practical recommendations for the use of renewable energy sources to ensure Ukraine's energy security in a rapidly changing external environment caused by a full-scale military invasion. The article analyses the state of renewable energy in Ukraine before and after the full-scale invasion. In particular, the general expediency of developing energy based on renewable energy sources was considered, and its positive and negative aspects of influence were described. The author analyses the main indicators characterising renewable energy: the dynamics of growth of the installed capacity of renewable energy facilities, the share of electricity generated from alternative sources in the overall energy balance, the distribution of renewable energy enterprises by regions and oblasts, the volume of energy production from alternative sources, and the total supply of energy from renewable sources. The main business entities in the renewable energy sector are identified. The losses of renewable energy facilities after the start of the full-scale invasion, the main problems faced by the renewable energy market and the risks that may arise are described. The article analyses the decisions of the state authorities in the field of renewable energy, which were made during the introduction of martial law to stabilise this market. The article provides recommendations for solving problematic aspects of the use of renewable energy sources under martial law in Ukraine and describes ways to improve the situation in the post-war period. Ensuring energy security in modern conditions has determined the relevance of this study.