bluuebunny/crossref_metadata_2025 huggingface dataset:
CORRELATION OF RELAPSE-FREE SURVIVAL WITH NEOADJUVANT TREATMENT IN PATIENTS WITH STAGE IIIA NON-SMALL CELL LUNG CANCER
Authors: Maliarchuk Kateryna A. , Ganul Andrey V. , Borisyuk Bogdan O. , Bororov Leonid B. , Shevchenko Anatoly I. , Sovenko Vladimir M.
Published: May 2022

The aim: The aim of this study was to investigate disease-free and overall survival in patients with stage IIII A NSCLC after neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy, and neoadjuvant chemotherapy.
Materials and methods: For the study, 3 groups of 65 people were taken. All patients underwent radical surgery in the form of lobectomy, bilobectomy or pneumonectomy. All groups received 3 or 4 courses of neoadjuvant chemotherapy according to the scheme Docitaxel (Paclitaxel) and Cisplatin (Carboplatin), while groups II and III also received, respectively, neoadjuvant and adjuvant radiation therapy in the amount of 30 Gy to the chest and mediastinum. Survival was assessed using the Kaplan and Mayer scale.
Results: 1. At a survival period of 6 months, the results of relapse-free survival in the NCRT and NCT groups do not differ. 2. From 12 months to 5 years, the highest recurrencefree survival rates are observed in the NHL group. 3. The overall five-year survival rate in the main group was 28.1±5.9%, in the NCT group - 10.4±3.8% and - 5.8±2.0% in the NCT + RT group.
Conclusions: The best recurrence-free survival results are observed in the NHLT group. Also, the largest number of cases of molars morphological response, correlated with the highest survival rates, also occurs in the NHL group.
CURRENT APPROACHES TO DIAGNOSIS AND TREATMENT OF HIRSCHSPRUNG DISEASE IN NEWBORNS AND INFANTS (LITERATURE REVIEW AND FIRST-HAND EXPERIENCE)
Authors: Gorbatyuk Olga M.
Published: May 2022

The aim: To analyze the current state of the issue of Hirschsprung disease in newborns and infants on the basis of literature data and first-hand experience.
Conclusions: 1. Hirschsprung disease should be suspected in all newborns with late meconium passage. 2. The main methods of diagnosing Hirschsprung disease in newborns and infants are the assessment of anamnestic data, clinical manifestations and features of the clinical course of the pathology, contrast enema, morphological examination of rectal biopsies and immunohistochemistry for ACE. 3. The presence of enterocolitis in newborns and infants should raise suspicion of Hirschsprung disease. 4. Low intestinal obstruction, perforation of the cecum, ascending or terminal small intestine, and peritonitis in the first days of a child’s life may be complications of Hirschsprung disease. 5. In newborns and infants, early diagnosis of Hirschsprung disease and timely surgical correction by one-stage surgery help improve treatment outcomes
IMPLEMENTATION OF ENHANCED RECOVERY AFTER SURGERY PROTOCOL FOR METABOLIC SURGERY PATIENTS (LITERATURE REVIEW)
Authors: Yevsieieva Viktoriia V. , Todurov Ivan M. , Perekhrestenko Olexandr V. , Kosiukhno Sergiy V.
Published: May 2022

The article reviews the literature highlighting modern views on the issues of postoperative rehabilitation of patients after metabolic surgical interventions. The concept of accelerated postoperative recovery of patients is presented as a single integral system of principles, means and methods of multidisciplinary work in the perioperative period aimed at reducing the time of hospitalization of patients and reducing the financial costs of the healthcare system. The separate components of the protocol of accelerated postoperative recovery from the standpoint of evidence-based medicine are analyzed, an emphasis is made on its specificity in metabolic surgery. The key role of laparoscopic access at the present stage of development of metabolic surgery is emphasized. Specific risk factors have been identified in patients with obesity, type 2 diabetes mellitus and metabolic syndrome, which can affect the effectiveness and safety of surgical treatment, especially in conditions of early discharge from the hospital. Attention is focused on the extremely important, but still controversial positions of the protocol, requiring further research to form a better evidence base and clear practical recommendations. The promising directions of scientific research for improving both the system of accelerated postoperative recovery as a whole and its individual elements are demonstrated. Electronic databases of Scopus and PubMed were searched using keyword searches. The analysis of the literature has shown the feasibility of introducing, systemic use and further improvement of the protocol for accelerated postoperative recovery in metabolic surgery.
ANALYSIS OF THE STATE AND WAYS OF INCREASING THE EFFICIENCY OF THE ODERNIZATION OF WEAPONS AND MILITARY EQUIPMENT IN THE ARMED FORCES OF UKRAINE
Authors: Suhin Oleg , Semenenko Oleg , Iefimenko Anatolii , Yarmolchyk Maria , Polyvoda Maksym
Published: May 2022

Today, the basis of defense planning in Ukraine should be the principles of forming programs and plans for the development of its law enforcement agencies, based on the needs of ensuring the required level of defense capabilities of the country as a whole by finding the optimal balance between defense needs and economic capabilities. The degree of fulfillment of tasks on equipping the Armed Forces of Ukraine (the AFU) with the latest or modernized models of armaments and military equipment (AME) depends on the state of financing of defense needs. Analysis of the availability of basic models of weapons and military equipment in the AFU, as well as the pace of their renewal showed today the most problematic issues of national scale is the state of existing AFU, as well as the current pace of modernization. The number of weapons that need to be replaced, upgraded and repaired is constantly increasing, and their condition is approaching unsatisfactory every year. The development or purchase of new modern models of AME of domestic or foreign production, modernization of existing complexes and systems, individual models of weapons, testing, serial production and equipping of military units of the AFU is an urgent problem today. considered a state-wide problem. In the article the authors analyze the development of AME of the AFU over the years of independence and reveal the dynamics of the ratio of the number of available and required basic samples of AFU to determine the magnitude of their mismatch. Based on the results, the practical recommendations have been developed on the algorithm of modernization of AME of the AFU. Failure to comply with a certain annual percentage of modernization of AME will sooner or later have a negative impact on the country’s military security level.
Keywords: combat capabilities, modernization of armaments and military equipment, financing of defense needs, military-economic factors, state of modernization, volumes of financial resources.
The New Opinion Leaders of Digital Marketing Era: Social Media Influencers
Authors: Taneri Ecem
Published: May 2022

The study examines the meaning of social media and social media influencers, penetration of social media platforms and the positioning of Instagram as a digital marketing tool. In this study, the growth of Instagram and influencer marketing are reviewed, how social media influencers and celebrities collaborate with brands and endorse them in social media platforms are approached. As a case study, digital marketing activities of four of the most preferred e-commerce platforms in Turkey have been examined during Black Friday; Trendyol, HepsiBurada, GittiGidiyor and Amazon. The reason why Black Friday, which is globally known as the opening day of shopping season, has been chosen as a case study is that retailers increase their digital marketing activities and market their sales on such special days. In this regard, the official Instagram accounts of the four noted e-commerce platforms have been analysed and Instagram posts with social media influencers and celebrity endorsement during Black Friday period have been studied. The study aims to contribute the literature by implying the usage of influencers by e-commerce platforms in terms of marketing perspective.
Janus face of sepsis: a viewpoint
Authors: Bauer Michael , Wetzker Reinhard
Published: May 2022

Treatment of sepsis currently relies on eliminating the causal pathogen and supportive care, whereas almost no approaches to interfere with the defining event of a “dysregulated host response” are available. This review points to the striking correlation of two phenotypes of sepsis etiopathology with the concept of bipartite response patterns of higher organisms to microbial attacks. According to this concept, the phenotypes of sepsis can be interpreted as either resistance or tolerance responses to infection that got out of hand. This concept might allow focusing sepsis research and related patient studies on key conundrums of current sepsis research: how do resistance responses result in immunopathology and how can tolerance lead to systemic immunosuppression or even immunoparalysis? The heuristic vigor of these questions might inspire experimental efforts and clinical studies and ultimately advance the therapeutic armamentarium for sepsis care.
Häirintä luottamushenkilöiden kokemuksissa
Authors: Kyösti Anni , Airaksinen Jenni , Paananen Henna
Published: May 2022

Artikkelissa tarkastellaan kuntien luottamushenkilöiden kokemaa häirintää ja uhkailua: Millaista häirintää kuntien luottamushenkilöt kohtaavat ja millaisia vaikutuksia häirintäkokemuksilla on? Tutkimuksessa yhdistetään aineistoja aineistotriangulaation avulla. Aineistoina on käytetty haastatteluja ja kyselyä. Laadullisen, tätä tutkimusta varten kerätyn haastatteluaineiston analyysimenetelmänä käytetään narratiivisesti orientoitunutta sisällönanalyysia.
Häirintäilmiötä kehystetään teoreettisesti poliittisen kulttuurin ja kompleksisen hallinnan tarkastelujen avulla. Tutkimus osoittaa, että luottamushenkilöt kohtaavat erilaisia häirinnän muotoja. Myös häirinnän kanavia on useita. Luottamushenkilöiden kohtaaman häirinnän eri muotojen tunnistaminen on tärkeää, jotta häirintään voidaan puuttua.
Häirinnällä on monenlaisia vaikutuksia. Yhteiskunnallisella tasolla pulmia aiheuttaa ehdokasasettelun hankaloituminen. Demokratian kannalta on vakavaa, jos ihmiset eivät uskalla asettua ehdolle häirinnän pelossa tai luopuvat luottamushenkilöpaikastaan häirintää koettuaan. Etenkin kuntapäätöksenteossa ehdokkaiden moninaisuus ja keskinäinen erilaisuus on nähty arvona. Lisäksi häirintä vaikuttaa julkiseen keskusteluun. Joistain asioista ei haluta keskustella julkisesti häirinnän pelossa, mikä saattaa vinouttaa poliittista keskustelua. Riskinä on myös häirinnän normalisoituminen.
IMPROVING THE ORGANIZATION OF TOPOGRAPHIC AND GEODETIC WORKS IN THE CADASTRAL SERVICE
Authors:   Master's degree student, Fergana Polytechnic Institute, Fergana, Uzbekistan, Turdimatova Gullola M. , Turdimatov Nurillo A. ,   Master's degree student, Fergana Polytechnic Institute, Fergana, Uzbekistan, Abduraupov Sayidjalol P. ,   Master's degree student, Fergana Polytechnic Institute, Fergana, Uzbekistan, Khakimova Kamolatkhon R. ,   PhD, Associate Professor, Fergana Polytechnic Institute, Fergana, Uzbekistan
Published: May 2022

As socio-economic factors developed, the land cadastre became fiscal in nature and served mainly tax purposes. Land cadastre is constantly evolving and improving as a special calculation and evaluation phenomenon that occurred at a certain stage of development of society, and first of all, there were changes in the methods and techniques of study, accounting, evaluation, classification of land types and qualities. Geodetic works play an important role in the cadastral service. Their composition depends on the level of cadastre management and its automation.
THE RESEARCH ON THE PRODUCTION OF SPECIAL CLOTHES FOR CAR REPAIRMEN, TAKING INTO ACCOUNT THE ERGONOMIC FEATURES OF A PERSON
Authors:   Master's Degree Student, Fergana Polytechnic Institute, Fergana, Uzbekistan, Tursunov Davronjon O. , Nabidjonova Nargiza N. ,   Doctor Of Technical Sciences, Associate Professor, Department Of Design And Technology Of Light Industry Products, Namangan Institute Of Engineering And Technology, Namangan, Uzbekistan
Published: May 2022

The main purpose of work clothes is to reliably protect the human body from various production factors while maintaining a normal functional condition and ability to work. Work clothes should not restrict the movement of the worker during the work process and should meet the needs that arise when used in accordance with the purpose, as well as be comfortable. Convenience affects not only the well-being of the employee but also his or her ability to work efficiently. These articles are devoted to the solution of designing special clothing for car repair workers, taking into account the ergonomic characteristics of men, and analysing the results of research for the design of special clothing.
THE IMPORTANCE OF ENRICHMENT OF BAKERY PRODUCTS WITH VITAMINS AND MINERALS ON HUMAN HEALTH
Authors:   PhD in Chemical Sciences, Associate Professor, Fergana Polytechnic Institute, Fergana, Uzbekistan, Barnokhon Sattarova , Nazira Utanova ,   Master’s Degree Student, Fergana Polytechnic Institute, Fergana, Uzbekistan, Aziza Makhmudova ,   Master’s Degree Student, Fergana Polytechnic Institute, Fergana, Uzbekistan
Published: May 2022

In this article we will talk about the importance of enriching bread products with micronutrients in human nutrition.
BASIC CONCEPTS AND PRINCIPLES OF INCLUSIVE EDUCATION
Authors:   Senior Lecturer, Fergana Polytechnic Institute, Fergana, Uzbekistan, .Ziyaev A
Published: May 2022

This article is devoted to the basic concepts and principles of inclusive education, since it is introduced for the first time in our university.
FUNDAMENTALS OF BIOTECHNOLOGY TO INCREASE THE MEAT PRODUCTIVITY OF POULTRY
Authors:   Scientific Research Institute of Livestock and Poultry, Uzbekistan, Tulaganova Zilola Kamoliddin kizi
Published: May 2022

It is known that in recent years the provision of the population with food products, especially meat, dairy and egg products, is one of the most important tasks of strategic importance. Particular attention is paid to poultry, from which it is possible to quickly and efficiently prepare meat and egg products. However, there are many challenges in providing them with essential nutrients such as nutritious, well-balanced nutrition, essential protein, vitamins, amino acids and minerals, and addressing them is an important issue. After all, there are still shortcomings in the import of nutrients from foreign countries, the assessment, use, storage and proper nutrition of their quantitative and qualitative indicators in the global standards.
CRIMINOLOGICAL DESCRIPTION OF ORGANIZED CRIME
Authors:   Teacher, Specialized Branch Of Tashkent State Law University, Department of Crime Prevention and Public Safety, Uzbekistan, Abdunabiyevich Eshkobilov Sirojiddin
Published: May 2022

This article provides an overview of the concept of organized crime, its specific features, causes and conditions, current trends, and statistics. It also provides recommendations for the prevention and elimination of organized crime.
USING CORPUS LINGUISTICS IN TEACHING LEISURE READING
Authors:   Master degree student, Uzbekistan State University of World Languages, Uzbekistan, Tolmasova Khursantosh Anvar kizi
Published: May 2022

The use of methods of applied linguistics in teaching a foreign language is considered. The potential of learning on the basis of corpus language material is analyzed. An analysis of such corpus linguistics methods as information retrieval (IR), data-driven learning, text searches in large-scale corpora (concordances), natural language processing methods (natural language processing) is presented. NLP)). In addition, the role and importance of the corps in leisure reading was studied.
Evidence for lateralized functional connectivity patterns at rest related to the tendency of externalizing or internalizing anger
Authors: Consolini Jennifer , Sorella Sara , Grecucci Alessandro
Published: May 2022

Previous electroencephalographic and brain stimulation studies have shown that anger responses may be differently lateralized in the prefrontal cortex, with outward-oriented responses (externalized anger) linked to left prefrontal activity, and inward-oriented responses (internalized anger) linked to right prefrontal activity. However, the specific neural structures involved in this asymmetry, and how they interact to produce individual differences, remain unexplored. Furthermore, it is unclear whether such asymmetry may be explained by general behavioral tendencies, known as Behavioral Activation and Behavioral Inhibition Systems (BIS/BAS). Therefore, we analyzed the tendency of externalizing and internalizing anger, respectively measured by the Anger-Out and Anger-In subscales of the State-Trait Anger Expression Inventory, with the patterns of functional connectivity at rest of 71 participants. A left, prefrontal, resting-state, functional connectivity pattern was found for externalizing anger (Anger-Out), including the left inferior frontal gyrus and the left frontal eye fields. By contrast, a right, prefrontal, resting-state, functional connectivity pattern was found for internalizing anger (Anger-In), including the rostral and lateral prefrontal cortex, the orbitofrontal cortex, the frontal pole, the superior, middle and inferior frontal gyri, and the anterior cingulate. Notably, these patterns were not associated with the BIS/BAS scores. In this study, for the first time, we provide evidence using fMRI functional connectivity for two specific lateralized circuits contributing to individual differences in externalizing and internalizing anger. These results confirm and extend the asymmetry hypothesis for anger and have notable implications in the treatment of anger-related problems.
Management of older and senile patients with a high risk of delirium when providing inpatient care. Clinical protocol
Authors: Isaev R. I. , Tkacheva O. N. , Runikhina N. K. , Sharashkina N. V. , Mkhitaryan E. A. , Cherdak M. A. , Manevich T. M. , Yakhno N. N.
Published: May 2022

Delirium is an acute, life-threatening condition manifested by disturbance in consciousness, attention and cognition, which has a multifactorial genesis, severe consequences and commonly seen in older and senile people inpatient. Clinical experience in domestic practice shows that delirium diagnosis in older and senile patients is often missed, and its signs may be considered as manifestations of other diseases, while the state of delirium is often perceived only as an alcohol withdrawal. The article presents a clinical protocol developed and based on the firsthand experience and modern ideas by a multidisciplinary team of the Russian Gerontology Research and Clinical Centre, in which the delirium in older and senile people is considered as a geriatric syndrome. The article shows the latest diagnostic criteria according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), the main diagnostic tools are given — Confusion assessment method (CAM), diagnostic and differential diagnostic algorithms; clinical subtypes, management tactics, non-drug and drug approaches to treatment, as well as principles for the prevention of geriatric delirium are described.
Pre-dementia cognitive impairment
Authors: Koberskaya N. N. , Mkhitaryan E. A. , Lokshina A. B. , Grishina D. A.
Published: May 2022

Cognitive disorders are one of the most significant problems of older. Special attention should be paid to the diagnosis of early pre-dementia stages of cognitive impairment (CI): subjective, subtle and mild.The aim of this study was to determine the criteria of pre-mild: subjective and subtle cognitive decline (SCD).Material and methods. The study included 602 patients with pre-mild cognitive impairment with a mean age of 63.24±11.24 years and 515 patients with mild cognitive impairment aged 71.2±8.0 years. The indicators of patients were compared with those of 104 healthy people (average age 64.23±8.14 years) who did not complain of memory impairment and had no deviations during clinical and neuropsychological examination.Results and discussion. Groups of patients with subjective and subtle cognitive decline were distinguished, which differed in most characteristics. At the same time, in both groups of patients, deviations in the results of neuropsychological tests did not exceed one standard deviation from the average results for healthy people, which, in fact, allowed them to be attributed to «pre-mild» cognitive decline. The data obtained confirmed the heterogeneity of the «pre-mild» cognitive decline. The study also shows the allocation limitation of pre-mild cognitive impairment only on the basis of a formal approach based on the quantitative characteristics of neuropsychological research with a difference from control groups necessarily exceeding one standard deviation.Conclusion. The analysis showed the heterogeneity of pre-dementia and pre-mild cognitive impairments that are divided according to the degree of changes in objectively assessed cognitive functions with the similarity of subjective complaints. It is proposed to distinguish subjective cognitive decline with completely normal neuropsychological characteristics and subtle cognitive decline in the event of changes in individual indicators evaluating mainly the control functions and memory.
A Review on Hyaluronidase as an Ideal adjuvant to Nerve Blocks.
Authors:   Associate Professor, Department of Anaesthesiology, Kasturba Medical college, Mangalore Manipal Academy of Higher Education, Manipal, India, Santha Neeta
Published: May 2022

Hyaluronidase has been used for decades as an adjunct to various drugs in medical field. Addition of the drug to local anaesthetic agent helps to improve the quality of anaesthesia. In this review article we are discussing about injectable hyaluronidase and its off label uses.
EFFECT ON CONCRETE TENSILE STRENGTH OF DIFFERENT DISTRICT OF GROUND WATER
Authors:   Department of Civil Engineering, Bhilai Institute of Technology, Durg (C.G.), India, SHRIVASTAVA SANDESH , SAXENA TUSHAR ,   Department of Civil Engineering, Bhilai Institute of Technology, Durg (C.G.), India
Published: May 2022

The quality of mixing water may affect the setting, hardening and strength of the concrete. Concrete is the most durable material and cement provides the large amount of energy to structural materials in concrete. Here the principal consideration is to mixing the quality and quantity of water into the concrete preparation. For the preparation of concrete quality of water always plays an major role. Quality of water may vary according to places; hence it may change the behaviour of concrete. It is seen that the water may affect strength, workability, setting time, tensile strength. According to IS3025 (PartII):1983, pH value of water should be potable between the range of 6.0 to 8.0 pH, it is favourable for construction work. The works aim is to provide a new approach of concrete tensile strength and also check the alkalinity, total suspended solids, sulphate, hardness etc. Samples are collected by different district (Durg, Rajnandgaon, Kawardha, Balod) of Chhattisgarh. Here we get different types of Minerals in every district. So This is done to determine the Split Tensile Strength Test of Concrete by making concrete cylinders. The samples of concrete (cylinder) were made for two different Grade i.e.mix design of M20 and M25. Keywords- Strength, Setting time, Water test, Impurity, pH value, Tensile Strength, Sieve analysis, W/C ratio, PPC cement, Workability test.
FORECAST METHODS FOR INVESTMENT OF COUNTRY WIDE ELECTRIC VEHICLE CHARGING STATIONS: LITHUANIAN CASE
Authors: Jaržemskis Andrius , Jaržemskienė Ilona
Published: May 2022

The aim of this article is to present a complex model for forecasting the required investments based on the forecast of the increase in the number of electric vehicles and their demand for energy and investments. Scientific problem is that current approach on forecasting of electric vehicles is to abstract, forecast models can’t be transferred from country to country. This article proposes a model of forecasting investments based on the fore-cast of the increase in the number of electric vehicles and their demand on energy. The findings of the Lithuanian case analysis, which is expressed in three scenarios, focuses on two trends. The most promising scenario projects 319 470 electric vehicles by 2030 which will demand for 1.09 TWh of electricity, representing 8.4–9.9 percent of the total en-ergy consumption in the country. It demands EUR 230.0 million in the low-voltage grid and EUR 209.0 million in the charging stations. Main limitations are related to statistics available for modelling and human behaviour uncertainty, especially in evaluation impact of measures to foster use of electric vehicles.
ATTITUDE TOWARDS SUSTAINABLE ENTREPRENEURSHIP AMONG STUDENTS: TESTING A MEASUREMENT SCALE
Authors: Titko Jelena , Tambovceva Tatjana , Atstaja Dzintra , Lapinskaite Indre , Solesvik Marina Z.
Published: May 2022

The overwhelming goal of the research is to evaluate the attitudes and behaviours of youth towards sustain-ability issues and sustainable entrepreneurship. The current paper reflects the results of the first research stage and aims at testing a measurement scale that consists of three groups of items: 1) statements about environmental attitudes and behaviours, 2) general intention to start a sustainable business, 3) intention to start a social business in the field of the circular economy. The reliability analysis to measure the internal consistency of the scale was performed in SPSS environment, using Cronbach alpha. A focus group discussion was organized among business students to evaluate the perceived quality of the questionnaire.
THE CONCEPTUAL MODEL OF THE STRUCTURE AND FUNCTIONAL PURPOSE OF THE GEOINFORMATION SYSTEM FOR ADMINISTRATIVE AND ECONOMIC MANAGEMENT OF A REGIONAL AIRPORT
Authors: Prusov Dmitry , Boyko Olena
Published: May 2022

This article is devoted to the development of a conceptual model of the structure of the geoinformation system (GIS) for the administrative and economic management of regional airports, taking into account the requirements of world and national experience, international and national standards, modern technologies of geospatial data collection. The research is aimed at structuring all the facilities and objects of the airport complex and isolating components by location and function; development of a generalized scheme of directions for the use of administrative and business GIS at airports based on the analysis of world and domestic experience; establishing the need to use international and national standards of the “Geographic Information / Geomatics” series when creating an airport GIS; development of a generic scheme of the composition of the database of the Digital Single Topographic Base of the Airport, basic and profile geoinformation resources for the administrative and economic GIS; development of conceptual model of structure and functional purpose of GIS of administrative and economic management of the airport. The developed conceptual model reflects the main production processes and needs of airports, based on the database of the Digital Numeral Topographic Framework, is a complete and consistent model of the relationship between the administrative and economic needs of airports and the functionality of modern geoinformation systems for the efficient operation of objects, structures and facilities communications, analysis of the current state, monitoring and management decision-making.
Electron Surfing Acceleration at Rippled Reconnection Fronts
Authors: Bai Kun , Yu Yiqun , Huang Hongtao , Tian Xingbin , Cao Jinbin
Published: May 2022

The reconnection front (RF), one of the most efficient accelerators of particles in the terrestrial magnetosphere, is a sharp plasma boundary resulting from transient magnetic reconnection. It has been both theoretically predicted and observationally confirmed that electron-scale substructures can develop at the RFs. How such electron-scale structures modulate the electron energization and transport has not been fully explored. Based on high-resolution data from MMS spacecraft and particle tracing simulations, we investigate and compare the electron acceleration across two typical RFs with or without rippled electron-scale structures. Both observations and simulations reveal that high-energy electron flux behind the RF increases more dramatically if the electrons encounter a rippled RF surface, as compared to a smooth RF surface. The main acceleration mechanism is electron surfing acceleration, in which electrons are trapped by the ripples, due to the large local magnetic field gradient, and therefore undergo surfing motion along the motional electric field.
The Effects of Disk-induced Apsidal Precession on Planets Captured into Mean Motion Resonance
Authors: Murray Zachary , Hadden Sam , Holman Matthew J.
Published: May 2022

The process of migration into resonance capture has been well studied for planetary systems where the gravitational potential is generated exclusively by the star and planets. However, massive protoplanetary disks add a significant perturbation to these models. In this paper we consider two limiting cases of disk-induced precession on migrating planets and find that small amounts of precession significantly affect the equilibrium reached by migrating planets. We investigate these effects with a combination of semianalytic models of the resonance and numerical integrations. We also consider the case of the disk’s dispersal, which can excite significant libration amplitude and can cause ejection from resonance for large enough precession rates. Both of these effects have implications for interpreting the known exoplanet population and may prove to be important considerations as the population of well-characterized exoplanet systems continues to grow.
Reionization with Simba: How Much Does Astrophysics Matter in Modeling Cosmic Reionization?
Authors: Hassan Sultan , Davé Romeel , McQuinn Matthew , Somerville Rachel S. , Keating Laura C. , Anglés-Alcázar Daniel , Villaescusa-Navarro Francisco , Spergel David N.
Published: May 2022

Traditional large-scale models of reionization usually employ simple deterministic relations between halo mass and luminosity to predict how reionization proceeds. We here examine the impact on modeling reionization of using more detailed models for the ionizing sources as identified within the 100 h
−1 Mpc cosmological hydrodynamic simulation Simba, coupled with postprocessed radiative transfer. Comparing with simple (one-to-one) models, the main difference with using Simba sources is the scatter in the relation between dark matter halos and star formation, and hence ionizing emissivity. We find that, at the power spectrum level, the ionization morphology remains mostly unchanged, regardless of the variability in the number of sources or escape fraction. In particular, the power spectrum shape remains unaffected and its amplitude changes slightly by less than 5%–10%, throughout reionization, depending on the scale and neutral fraction. Our results show that simplified models of ionizing sources remain viable to efficiently model the structure of reionization on cosmological scales, although the precise progress of reionization requires accounting for the scatter induced by astrophysical effects.
Genetic Study of Chemokine Ligand 1 in Colorectal Carcinoma using Quantitative Real-Time PCR
Authors: Alshimerry Athraa , Khudhair Dalia Amer , Mahdi Roaa Salih
Published: May 2022

Background: Carcinoma of colon is one of the prevalence carcinoma in the world and it is the most important cause of death in Western countries. The disease process is multifactorial; with etiology include inflammatory conditions of the digestive tract, environmental liableness and genetic factors. Chemokine Ligand1 was share in several mechanisms such as inflammatory process, chemo attraction, and others. Objective: The current study was conducted to analyze gene expression level of chemokine ligand 1 in colonic carcinoma and to deliberate the participant of it as genetic factors in its evolving and prognosis. Material and method: Chemokine Ligand1 gene expression level was evaluated in formalin-fixed, paraffin embedded tissue blocks that is retrospectively collected from 40 patients (8 women and 32 men) with carcinoma, and 40 patients of normal colonic tissues as control specimen by using Real-Time PCR. Results: The expression of Chemokine ligand 1 gene were established as 12.4112 folds in carcinoma specimen in relation to control tissue (1.3492).  Chemokine ligand 1 genes were found to be over-expressed in advanced stage tumors and elderly patients. Conclusions: Chemokine ligand1 can be considered as a recent biomarker and the possibility to use it as therapeutic target in the treatment of colonic carcinoma.
Assessment of Cardiac Functions and Arrhythmia in Children with Beta-Thalassemia Major and Beta-Thalassemia Intermedia
Authors: Salama Khaled , Khaled Hanan Zekri , El Dien Hadeel Mohamed Seif , Afifi Rasha Abdel-Raouf Abdel-Aziz , Shaheen Naglaa Mohamed Mahmoud , El Wahab Mehan Abdalla Mohamed Abd
Published: May 2022

BACKGROUND: Heart disease is a major complication in thalassemic patients. Heart injuries in iron overload cases include arrhythmia, pulmonary hypertension, systolic/diastolic dysfunction, and heart failure.

AIM: This study aimed to assess cardiac functions and arrhythmia in children with β-thalassemia major (TM) and β-thalassemia intermedia (TI) and its relation to cardiac iron overload.

METHODS: Thirty β-TM patients and 30 β-TI patients were evaluated using echocardiography and 24-h ambulatory electrocardiogram monitoring (Holter). Among these patients, 15 β-TM and 15 β-TI patients were evaluated using cardiac magnetic resonance imaging T2* by single breath-hold multi-echo technique.

RESULTS: Arrhythmia was detected significantly more in β-TM patients than β-TI (p = 0.049). Nine (30%) β-TM and five (16.6%) β-TI patients had Sinus tachycardia. Two (6.7%) β-TM patients compared to one (3.33%) β-TI patient had supraventricular tachycardia runs. Three (10%) β-TM and one (3.33%) β-TI patient had extreme sinus tachycardia. Two (3.3%) β-TI patients had sinus bradycardia, while two (3.3%) β-TM patients had incomplete Right bundle branch block. Regarding echo parameters: Isovolumic relaxation time (IVRT), Left ventricle myocardial performance index (MPI LV), Right ventricle myocardial performance index (MPI RV) and end systolic pulmonary artery pressure, were significantly higher in β-TM than TI group (p < 0.05). Fractional shortening, Ejection fraction were significantly lower in β-TM than TI group (p < 0.001). A statistically significant negative correlation was found between cardiac T2* and each of (IVRT, MPI LV, MPI RV) (p ˂ 0.05).

CONCLUSION: Arrhythmias are more common in the β-TM group. Systolic, diastolic dysfunction and high pulmonary pressure are more prevalent in TM than in TI. Global myocardial performance is more impaired in TM than in TI patients. Iron overload has a deleterious effect on cardiac function.
Morphological Types of Anemia Associated with Chronic Renal Diseases
Authors: Mohammed Mazin Razooqi , Mahmood Bushra
Published: May 2022

Introduction: Anemia develops early in the course of renal disease and worsens as kidney function declines; a typical consequence of CKD is caused by a disruption in erythropoietin production as well as caused by iron and vitamin shortages, blood loss, shortened erythrocyte life span, chronic inflammation, and the uremic environment. Aim: Our study aimed to identify and classify different types of anemia that complicated patient with chronic kidney disease. Methods: 40 patient were included in this study, 32 males (80%) and 8 females (20%), the age range was 40-70 for male and 48-68 for female .Depending on clinical sign, symptoms and laboratory diagnostic test All those patient are diagnosed previously as a cases of chronic renal failure by clinicians in our city and develop anemia during the course of diseases, so clinicians referred patients to our laboratory to find the cause of anemia. Depending’s on hematological laboratory data, peripheral blood smear examination from these 40 patients, which showed different types of anemia. Results: the most common types of anemia was Normochromic anemia (62.5 %) which develop in 25 patients followed by hypochromic microcytic anemia (8 %) which develop in 8 patients, and followed by macrocytic anemia (12.5 %) which develop in 5 patients and the less common type of anemia was hemolytic anemia (5 %) which was founded in 2 patients.. Conclusion: All types of anaemia can be detected in-patient with different types of renal diseases and it’s important to used different type of laboratory test to diagnosed type of anemia to treat it.
Plankton hitch-hikers on naturalists’ instruments as silent intruders of aquatic ecosystems: current risks and possible prevention
Authors: Wejnerowski Łukasz , Aykut Tümer Orhun , Pełechata Aleksandra , Rybak Michał , Dulić Tamara , Meriluoto Jussi , Dziuba Marcin Krzysztof
Published: May 2022

Organism dispersal is nowadays highly driven by human vectors. This also refers to the aquatic organisms that can often silently spread in and invade new waters, especially when human vectors of dispersal act without brakes. Thus, it is mandatory to continuously identify human-mediated mechanisms of organism dispersal and implement proper biosecurity treatments. In this study, we demonstrate how the plankton net – one of the basic instruments in the equipment of every plankton sampling person is a good vector for plankton dispersal and invasions. We also demonstrate whether keeping the net in an ethanol solution after sampling is a proper biosecurity treatment, and what kind of treatments are implemented by people worldwide. The first simulation shows that bloom-forming cyanobacteria can easily infiltrate into the new environment thanks to the nets, and can prosper there. However, ethanol-based biosecurity treatment efficiently prevented their spread and proliferation in the new environment. The second simulation, based on wild plankton from an eutrophic lake, indicates that a plethora of phyto- and zooplankton taxa can infiltrate into the new waterbody through the net and sustain themselves there if the net is only flushed in the waterbody and left to dry after sampling (an approach that is commonly used by naturalists). Here, we also show that native plankton residents strongly shape the fate of hitch-hikers, but some of them like cyanobacteria can successfully compete with residents. Survey data alert us to the fact that the vast majority of biologists use either ineffective or questionable biosecurity treatments and only less than a tenth of samplers implement treatments based on disinfectant liquids. Our results emphasize that the lack of proper biosecurity methods implemented by the biologists facilitates the spread and invasions of plankton including also invasive species of a great nuisance to native ecosystems. Considering that naturalists usually use different instruments that might also be good vectors of plankton dispersal, it is necessary to develop proper uniform biosecurity treatments. No longer facilitating the plankton spread through hydrobiological instruments is the milestone that we, plankton samplers worldwide, should achieve together in the nearest future if we want to continue our desire to explore, understand, protect and save nature.
Conflits au travail et besoin de reconnaissance. Quels enjeux pour la médiation ?
Authors: Martinez Candice
Published: May 2022

À partir d’une expérience originale de collaboration entre une sociologue et des médiateurs, une démarche de recherche participative suivie de la mise en place de médiations dans des conflits au travail au sein d’établissements sociaux et médico-sociaux a été menée. Des entretiens et questionnaires ont été réalisés afin de saisir les conceptions du conflit au travail du point de vue des équipes de direction et des professionnels de terrain ; la connaissance préalable, les attentes et les représentations de la médiation ; les effets du processus de médiation sur le conflit. Partant de travaux issus de la sociologie des organisations et de la sociologie des relations professionnelles, cet article explore les apports du concept de reconnaissance pour comprendre les dynamiques de conflit au travail dans les établissements médico-sociaux et le rôle que peut avoir la médiation pour ouvrir des espaces de dialogue sur le travail et sur l’activité.
L’écriture subjective du temps. La représentation du présent d’après le passé, la réécriture du passé au présent
Authors: Prouvez Valentine
Published: May 2022

Le temps renvoie, dans sa plus simple définition, au fait que les choses passent. C’est à la fois parce que nous sommes conscients de notre propre existence et de celle des objets qui nous entourent, et parce que nous pouvons nous souvenir de ce que nous ne percevons plus au moment présent, que nous est donné intuitivement le temps : les notions de passé, de présent et d’avenir. Notre représentation ordinaire du temps est linéaire : nous pensons l’existence comme une succession chronologique d’évènements. Cette représentation de l’existence dans le temps présente cependant certains paradoxes, manifestes dans cette formule usuelle : « Tu n’as pas changé. Qu’est-ce que tu deviens ? ». Nous proposons de nous intéresser à ce paradoxe inhérent à notre rapport subjectif au temps, dans une approche croisée entre biologie, psychanalyse et philosophie.
Les casques verts et la protection de l’environnement en Afrique : le cas des forces de la MISCA
Authors: Garcia Nyangono Noa Manuela
Published: May 2022

Les liens complexes entre environnement, sécurité et conflits en Afrique ont conduit à la sécuritisation de l’environnement par l’Union africaine dans l’Architecture de paix et sécurité africaine. Cette sécuritisation, entendue comme les processus à l’intérieur desquels émerge la sécurité environnementale, a été élaborée dans le but de répondre aux conséquences des catastrophes naturelles en apportant une assistance aux sinistrés et en endiguant les menaces contre les ressources environnementales indispensables au bien-être de la population, mais également dans l’optique de mettre la protection de l’environnement au service de la paix et la sécurité en Afrique. Les casques verts, principal dispositif opérationnel de l’Architecture de paix et sécurité africaine, constituent à cet effet des acteurs clés de la protection de l’environnement par les opérations de maintien de la paix. Dans un contexte caractérisé par l’africanisation des opérations de maintien de la paix, cet article s’interroge sur la définition et la mise en application de la sécurité environnementale dans les activités des casques verts et fait ressortir la place de la sécurité environnementale dans la construction et la consolidation de la paix en Afrique. Il prend appui sur la Mission internationale de soutien à la Centrafrique (MISCA) et interroge les mandats des OMP africaines afin d’en déterminer les ressorts normatifs de la sécuritisation de l’environnement et analyse le rôle des casques verts dans la protection de l’environnement en montrant comment les champs de la sécurité individuelle et de la sécurité environnementale se rencontrent dans la mise en œuvre des OMP.
Les risques sécuritaires climatiques à l’ONU (1990-2020)
Authors: Lehtonen Matti
Published: May 2022

Au cours des trente dernières années, les Nations unies ont soutenu des mesures concrètes visant à garantir que l’environnement et les ressources naturelles partagées contribuent à la paix plutôt qu’aux conflits. Cela nécessite une collaboration entre les mandats sectoriels des différents programmes, faisant le lien entre les acteurs de la paix et de la sécurité et les entités plus techniques. Alors que l’attention se tourne vers les risques sécuritaires liés au climat, les approches intégrées évoluent. En 2018, le Mécanisme de sécurité climatique a été créé pour catalyser les efforts de l’ONU, en s’appuyant sur l’expertise existante. Alors que de nouvelles pratiques conjointes émergent, il existe des opportunités pour des approches davantage orientées vers l’anticipation et l’avenir.
L’adaptation au changement climatique : d’abord de l’intelligence mise dans les projets
Authors: Nicol Morgane , Dépoues Vivian
Published: May 2022

Alors que les bénéfices de l’anticipation sont largement démontrés, le niveau d’adaptation aux changements climatiques en France reste faible. Ce constat invite à analyser les barrières rencontrées par les acteurs qui cherchent à se saisir du sujet. Dans cet article, nous revenons sur deux des cas d’étude conduits dans le cadre du projet de recherche Finadapter, tous deux situés en contexte urbain : la mise en œuvre du plan d’adaptation de la métropole européenne de Lille et l’aménagement d’une ZAC en zone inondable dans la métropole nantaise. Ces deux cas montrent la nature des réponses à déployer, qui loin d’être uniquement des solutions techniques prêtes à l’emploi prennent également et le plus souvent la forme de combinaisons de mesures toujours spécifiques à un contexte. L’analyse de ces situations tend à démontrer qu’adapter un territoire au changement climatique n’engendre pas systématiquement des surcoûts importants, mais demande d’y consacrer des ressources humaines, du temps et une expertise pour interroger la manière dont sont conduits certains projets et certaines politiques.
Biodiversité et climat : les approches fondées sur la nature
Authors: Couvet Denis , Soubelet Hélène
Published: May 2022

Une meilleure gestion des écosystèmes pourrait contribuer à une atténuation significative du changement climatique. Pour y parvenir un certain nombre de conditions doivent être réunies : préserver et restaurer la diversité biologique de ces écosystèmes, y compris celle des communautés animales et microbiennes ; faciliter l’adaptation de ces écosystèmes aux changements globaux en maintenant des corridors et en réduisant les perturbations ; et tenir compte de la diversité des territoires en intégrant les savoirs et les valeurs associés.
Les extrêmes climatiques : perceptions et enjeux sociaux et politiques
Authors: Martin Solange
Published: May 2022

Alors que le changement climatique se concrétise dans le monde et en France, deux années de pandémie n’ont pas relégué la préoccupation environnementale à l’arrière-plan. Particulièrement tangibles, destructeurs et redoutés, les événements climatiques extrêmes contribuent à ancrer la réalité de l’urgence climatique dans l’opinion publique. Amenés à se reproduire de façon plus fréquente et plus intense dans le futur, ces événements rappellent également la nécessité de savoir ce que produisent ces nouveaux risques environnementaux sur les individus et les sociétés. Les sciences humaines, sociales et économiques permettent d’éclairer les multiples enjeux de cette situation. L’accroissement de l’éco-anxiété mais aussi des tensions et des conflits souligne l’urgence d’y faire collectivement face. Que chacun fasse sa part ne doit pas masquer le fait que l’urgence climatique est aussi, et même surtout, politique et sociale.
On the exact solutions of nonlinear extended Fisher-Kolmogorov equation by using the He's variational approach
Authors: Nisar Kottakkaran Sooppy , Alsallami Shami Ali Mohammed , Inc Mustafa , Iqbal Muhammad Sajid , Baber Muhammad Zafarullah , Tarar Muhammad Akhtar
Published: May 2022

In this article, we investigate existence and the exact solutions of the extended Fisher-Kolmogorov (EFK) equation. This equation is used in the population growth dynamics and wave propagation. The fourth-order term in this model describes the phase transitions near critical points which are also known as Lipschitz points. He's variational method is adopted to construct the soliton solutions as well as the periodic wave solutions successfully for the extended (higher-order) EFK equation. This approach is simple and has the greatest advantages because it can reduce the order of our equation and make the equation more simple. So, the results that are obtained by this approach are very simple and straightforward. The graphics behavior of these solutions are also sketched in 3D, 2D, and corresponding contour representations by the different choices of parameters.