bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Methods, Figures 1-5, Table 1 from CXCR4 Activation Defines a New Subgroup of Sonic Hedgehog–Driven Medulloblastoma
Authors: Sengupta Rajarshi , Dubuc Adrian , Ward Stacey , Yang Lihua , Northcott Paul , Woerner B. Mark , Kroll Kirsten , Luo Jingqin , Taylor Michael D. , Wechsler-Reya Robert J. , Rubin Joshua B.
Published: April 2023

PDF file - 2MB
Supplementary Figure 1 from Cancer Angiogenesis Induced by Kaposi Sarcoma–Associated Herpesvirus Is Mediated by EZH2
Authors: He Meilan , Zhang Wei , Bakken Thomas , Schutten Melissa , Toth Zsolt , Jung Jae U. , Gill Parkash , Cannon Mark , Gao Shou-Jiang
Published: April 2023

PDF file - 101K, KSHV infection converts BOEC cells into spindle shape, and upregulates the expression of lymphatic endothelial markers
Supplementary Table 1 from IKK-ϵ Coordinates Invasion and Metastasis of Ovarian Cancer
Authors: Hsu Sarah , Kim Marianne , Hernandez Lidia , Grajales Valentina , Noonan Anne , Anver Miriam , Davidson Ben , Annunziata Christina M.
Published: April 2023

PDF file - 155K, Short hairpin RNA sequences
Supplementary Figure Legends 1-7 from Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis
Authors: Zhang Yi , Cheng Yan , Ren Xingcong , Hori Tsukasa , Huber-Keener Kathryn J. , Zhang Li , Yap Kai Lee , Liu David , Shantz Lisa , Qin Zheng-Hong , Zhang Suping , Wang Jianrong , Wang Hong-Gang , Shih Ie-Ming , Yang Jin-Ming
Published: April 2023

PDF file - 120K
Supplementary Figures 1-5 from Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1
Authors: Wang Jingna , Han Xiangzi , Zhang Youwei
Published: April 2023

PDF file - 593K, S1 (A) HEK293T cells were transfected with Myc-Chk1 WT or D148A mutant for 48 hr, treated with 2 �M MG132 for additional 12 hr, and immunoblotted with indicated antibodies. (B) Alignment of the domain from CM1 to the distal C-terminus of Chk1 from different species. Figure S2 (A) HEK293T cells were transfected with Myc-tagged Chk1 FL, N- or Cterminal fragments for 48 hr, immunoblotted with indicated antibodies. (B) Schematic diagram of generating GFP-tagged Chk1 C terminal fragments. (C) HEK293T cells were transfected with Myc-Chk1 N-terminus and GFP-tagged Chk1 C-terminal fragments for 48 hr, immunoprecipitated with anti- Myc antibodies and immunoblotted with anti-GFP antibodies. (D) Myc-Chk1 WT or L449R mutant proteins were produced by in vitro transcription and translation, and used to perform in vitro kinase assay with the GST-Cdc25C (200-256) as the substrate. Figure S3 Constitutive activation of Chk1 inhibits S phase progression. Figure S4 HeLa Tet/Off cells were transfected and treated as shown in Figure S3A, cells were collected and cell cycle profile of GFP-positive cells was determined by flow cytometry. Figure S5 Models for Chk1 phosphorylation under different situations
Supplementary Figure 1 from Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis
Authors: Zhang Yi , Cheng Yan , Ren Xingcong , Hori Tsukasa , Huber-Keener Kathryn J. , Zhang Li , Yap Kai Lee , Liu David , Shantz Lisa , Qin Zheng-Hong , Zhang Suping , Wang Jianrong , Wang Hong-Gang , Shih Ie-Ming , Yang Jin-Ming
Published: April 2023

PDF file - 160K, Effects of NAC1 status on growth and SA-�-gal activity of tumor
Supplementary Figure 2 from Receptor Tyrosine Kinase Genes Amplified in Glioblastoma Exhibit a Mutual Exclusivity in Variable Proportions Reflective of Individual Tumor Heterogeneity
Authors: Little Suzanne E. , Popov Sergey , Jury Alexa , Bax Dorine A. , Doey Lawrence , Al-Sarraj Safa , Jurgensmeier Juliane M. , Jones Chris
Published: April 2023

PDF file - 7.6MB
Supplementary Figure 4 from CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells
Authors: De Falco Valentina , Tamburrino Anna , Ventre Simona , Castellone Maria Domenica , Malek Mouhannad , Manié Serge N. , Santoro Massimo
Published: April 2023

PDF file - 141K, RET-PTC triggers CD44-ICD and CD44-CTF production
Supplementary Figure 7 from NAC1 Is an Actin-Binding Protein That Is Essential for Effective Cytokinesis in Cancer Cells
Authors: Yap Kai Lee , Fraley Stephanie I. , Thiaville Michelle M. , Jinawath Natini , Nakayama Kentaro , Wang Jianlong , Wang Tian-Li , Wirtz Denis , Shih Ie-Ming
Published: April 2023

PDF file - 76K, Supporting data of quantitative binding assay
Supplementary Table 2 from Kidney Tumor Biomarkers Revealed by Simultaneous Multiple Matrix Metabolomics Analysis
Authors: Ganti Sheila , Taylor Sandra L. , Abu Aboud Omran , Yang Joy , Evans Christopher , Osier Michael V. , Alexander Danny C. , Kim Kyoungmi , Weiss Robert H.
Published: April 2023

PDF file - 47K, R2 and Q2 values of the first 3 latent components for distinguishing cancer and sham surgery mice based on the metabolome in the tissue, serum and urine
Supplementary Figure Legends 1-4 from Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche
Authors: Sceneay Jaclyn , Chow Melvyn T. , Chen Anna , Halse Heloise M. , Wong Christina S.F. , Andrews Daniel M. , Sloan Erica K. , Parker Belinda S. , Bowtell David D. , Smyth Mark J. , Möller Andreas
Published: April 2023

PDF file - 72K
Supplementary Methods, Figures 1-9 from Vanilloid Receptor-1 Regulates Neurogenic Inflammation in Colon and Protects Mice from Colon Cancer
Authors: Vinuesa Amaya G. , Sancho Rocío , García-Limones Carmen , Behrens Axel , ten Dijke Peter , Calzado Marco A. , Muñoz Eduardo
Published: April 2023

PDF file - 2.5MB
Supplementary Figure 3 from Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia
Authors: Garbe James C. , Pepin Francois , Pelissier Fanny A. , Sputova Klara , Fridriksdottir Agla J. , Guo Diana E. , Villadsen Rene , Park Morag , Petersen Ole W. , Borowsky Alexander D. , Stampfer Martha R. , LaBarge Mark A.
Published: April 2023

PDF file - 2.3MB, Lineage marker distributions in cultured and uncultured HMEC. Sevenparameter flow cytometry analyses of 4th passage HMEC strains
Supplementary Figures 1-13 from Cell-Mediated Autophagy Promotes Cancer Cell Survival
Authors: Buchser William J. , Laskow Thomas C. , Pavlik Philip J. , Lin Hui-Min , Lotze Michael T.
Published: April 2023

PDF file - 1.2MB, 1) cell population discrimination and lysis, 2) CD4 T-cell C-MA, 3) ATG5 KO, 4) Prolonged survival, 5) Caspase and Granzyme inhibitors, 6) Bafilomycin and LAMP1, 7) Imaging starvation and HCQ, 8) TGF-beta, 9)NKG2D ligands, 10) KIR inhibition, 11) STAT1,2 translocation and IFNGR1, 12) IFN alpha combinations, 13) Chemotherapy.
Supplementary Table 1 from Viral RNA Patterns and High Viral Load Reliably Define Oropharynx Carcinomas with Active HPV16 Involvement
Authors: Holzinger Dana , Schmitt Markus , Dyckhoff Gerhard , Benner Axel , Pawlita Michael , Bosch Franz X.
Published: April 2023

PDF file - 57K, Table S1. Integrated Prediction Error (5 years range of integration). To estimate the prediction error we used the .632+ estimate of the integrated Brier score. For OS the cumulative prediction error decreased from 0.192 for the model with clinical factors to 0.182 using additional HPV marker combination and to 0.183 using additional CxCa-like viral RNA patterns. On the contrary, no improvement in prediction accuracy was observed for PFS by adding single HPV markers or marker combinations to clinical factors.
Supplementary Figures 1-5 from Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer
Authors: Liu Xiyong , Lai Lily , Wang Xiaochen , Xue Lijun , Leora Sofia , Wu Jun , Hu Shuya , Zhang Keqiang , Kuo Mei-Ling , Zhou Lun , Zhang Hang , Wang Yafan , Wang Yan , Zhou Bingsen , Nelson Rebecca A. , Zheng Shu , Zhang Suzhan , Chu Peiguo , Yen Yun
Published: April 2023

Supplementary Figures 1-5 from Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer
Supplementary Table 2 from Fibroblast-Derived Dermal Matrix Drives Development of Aggressive Cutaneous Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis Bullosa
Authors: Ng Yi-Zhen , Pourreyron Celine , Salas-Alanis Julio C. , Dayal Jasbani H.S. , Cepeda-Valdes Rodrigo , Yan Wenfei , Wright Sheila , Chen Mei , Fine Jo-David , Hogg Fiona J. , McGrath John A. , Murrell Dedee F. , Leigh Irene M. , Lane E. Birgit , South Andrew P.
Published: April 2023

XLS file - 8K, describing KEGG pathway analysis results
Supplementary Figure 3 from Fibroblast-Derived Dermal Matrix Drives Development of Aggressive Cutaneous Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis Bullosa
Authors: Ng Yi-Zhen , Pourreyron Celine , Salas-Alanis Julio C. , Dayal Jasbani H.S. , Cepeda-Valdes Rodrigo , Yan Wenfei , Wright Sheila , Chen Mei , Fine Jo-David , Hogg Fiona J. , McGrath John A. , Murrell Dedee F. , Leigh Irene M. , Lane E. Birgit , South Andrew P.
Published: April 2023

PDF file - 409K, Invasion of SCCRDEB4 keratinocytes into RDEB cell derived matrix is increased after 1 week compared with equivalent non-RDEB cell derived matrix. Representative images from pan-keratin stained images of 1-week invasion of tumor cells into fibroblast derived matrix. Magnification 200X.
Supplementary Figure 2 from Clusterin Mediates TGF-β–Induced Epithelial–Mesenchymal Transition and Metastasis via Twist1 in Prostate Cancer Cells
Authors: Shiota Masaki , Zardan Anousheh , Takeuchi Ario , Kumano Masafumi , Beraldi Eliana , Naito Seiji , Zoubeidi Amina , Gleave Martin E.
Published: April 2023

PDF file - 38K, PC-3 cells were transfected with 0.5 mug/mL of the CLU-Luc -1,998/+254, 0.5 mug/mL of the indicated expression plasmid, and 0.05 mug/mL of pRL-TK. The luciferase activity of CLU-Luc -1,998/+254 with mock plasmid (Myc-Flag) was set as 1. Boxes, mean; bars, �s.d. *P < 0.05 (compared with mock). Whole-cell extracts were analyzed by SDS-PAGE and western blot analysis with specified antibodies
Supplementary Figure 2 from BRAF Inhibitor Vemurafenib Improves the Antitumor Activity of Adoptive Cell Immunotherapy
Authors: Koya Richard C. , Mok Stephen , Otte Nicholas , Blacketor Kevin J. , Comin-Anduix Begonya , Tumeh Paul C. , Minasyan Aspram , Graham Nicholas A. , Graeber Thomas G. , Chodon Thinle , Ribas Antoni
Published: April 2023

PDF file - 190K, Flow cytometric analysis of H2-Db expression by SM1 with or without exposure to vemurafenib for different periods
Supplementary Methods from Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer
Authors: Cai Houjian , Memarzadeh Sanaz , Stoyanova Tanya , Beharry Zanna , Kraft Andrew S. , Witte Owen N.
Published: April 2023

PDF file, 28K, Includes information on mice strains, plasmids, as well as immunohistochemistry and western blot analysis.
Supplementary Figure 6 from Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer
Authors: Cai Houjian , Memarzadeh Sanaz , Stoyanova Tanya , Beharry Zanna , Kraft Andrew S. , Witte Owen N.
Published: April 2023

PDF file, 91K, Sphere formation of normal primary prostate cells is suppressed by DZNep.
Supplementary Table 1 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
Authors: Poage Graham M. , Butler Rondi A. , Houseman E. Andrés , McClean Michael D. , Nelson Heather H. , Christensen Brock C. , Marsit Carmen J. , Kelsey Karl T.
Published: April 2023

PDF file - 5K, Primers Used In Pyrosequencing Validation
Supplementary Figure 4 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
Authors: Poage Graham M. , Butler Rondi A. , Houseman E. Andrés , McClean Michael D. , Nelson Heather H. , Christensen Brock C. , Marsit Carmen J. , Kelsey Karl T.
Published: April 2023

PDF file - 94K, Specificity analysis for survival association with PcG|MIR|TFBS locus methylation
Supplementary Figure 1 from Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer
Authors: Cai Houjian , Memarzadeh Sanaz , Stoyanova Tanya , Beharry Zanna , Kraft Andrew S. , Witte Owen N.
Published: April 2023

PDF file, 213K, Synergy of Akt signaling with AR promotes the progression of prostate cancer.
Supplementary Table 4 from Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
Authors: Su Fei , Bradley William D. , Wang Qiongqing , Yang Hong , Xu Lizhong , Higgins Brian , Kolinsky Kenneth , Packman Kathryn , Kim Min Jung , Trunzer Kerstin , Lee Richard J. , Schostack Kathleen , Carter Jade , Albert Thomas , Germer Soren , Rosinski Jim , Martin Mitchell , Simcox Mary Ellen , Lestini Brian , Heimbrook David , Bollag Gideon
Published: April 2023

PDF file - 54K
Supplementary Methods and Materials, Figures 1-9 from GLI1 Inhibition Promotes Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells
Authors: Joost Simon , Almada Luciana L. , Rohnalter Verena , Holz Philipp S. , Vrabel Anne M. , Fernandez-Barrena Maite G. , McWilliams Robert R. , Krause Michael , Fernandez-Zapico Martin E. , Lauth Matthias
Published: April 2023

PDf file - 405K
Supplementary Table 7 from Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model
Authors: Floc'h Nicolas , Kinkade Carolyn Waugh , Kobayashi Takashi , Aytes Alvaro , Lefebvre Celine , Mitrofanova Antonina , Cardiff Robert D. , Califano Andrea , Shen Michael M. , Abate-Shen Cory
Published: April 2023

DOC file, 347K, GSEA data for the castrated mice.
Supplementary Table 2 from VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression
Authors: Cao Ying , E Guangqi , Wang Enfeng , Pal Krishnendu , Dutta Shamit K. , Bar-Sagi Dafna , Mukhopadhyay Debabrata
Published: April 2023

PDF file - 60K, PCR primer sequences and products size
Supplementary Methods from VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression
Authors: Cao Ying , E Guangqi , Wang Enfeng , Pal Krishnendu , Dutta Shamit K. , Bar-Sagi Dafna , Mukhopadhyay Debabrata
Published: April 2023

PDF file - 79K, Includes information on Antibodies and Western Blotting, Cell Proliferation Assay, as well as RNA extraction and Reverse Transcription-PCR data
Supplementary Figures 1-8 from ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features
Authors: Albino Domenico , Longoni Nicole , Curti Laura , Mello-Grand Maurizia , Pinton Sandra , Civenni Gianluca , Thalmann George , D'Ambrosio Gioacchino , Sarti Manuela , Sessa Fausto , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: April 2023

PDF file - 432K, Supplementary Figure 1 Histopathological and clinical parameters of primary prostate cancer patients in the two patient cohorts evaluated by TMAs. Supplementary Figure 2 ESE3/EHF knockdown induces epithelial to mesenchymal transition Supplementary Figure 3 Transient downregulation of ESE3/EHF induces a mesenchymal phenotype Supplementary Figure 4 In vivo formation of lung metastasis Supplementary Figure 5 Prostato-sphere formation by prostate epithelial cells Supplementary Figure 6 Transient downregulation of ESE3/EHF in PrECs and RWPE-1 cells induces stem-like properties Supplementary Figure 7 Prostato-sphere formation and stem-like properties in DU145 cells Supplementary Figure 8 Overall survival and PSA biochemical relapse in prostate cancer patients
Supplementary Figures 1-9 from MET Signaling Regulates Glioblastoma Stem Cells
Authors: Joo Kyeung Min , Jin Juyoun , Kim Eunhee , Ho Kim Kang , Kim Yonghyun , Gu Kang Bong , Kang Youn-Jung , Lathia Justin D. , Ho Cheong Kwang , Song Paul H. , Kim Hyunggee , Seol Ho Jun , Kong Doo-Sik , Lee Jung-Il , Rich Jeremy N. , Lee Jeongwu , Nam Do-Hyun
Published: April 2023

PDF file - 6.4MB, Figure S1: High MET mRNA expression in GBM specimens portends poor patient survival. Figure S2: Dual immunofluorescence of MET and GSC enrichment markers (CD133 and CD15) on the frozen sections of GBM specimens. Figure S3: HGF/MET signaling in GBMs. Figure S4: METhigh cells generated xenograft tumors consisting of both METhigh and METlow/- cells. Figure S5: Immunohistochemical analysis of HGF protein in orthotopic xenograft tumors derived of from GBM 578 (A and C) and 464 (B and D). Figure S6: Effects of MET blockade on cell survival and clonogenicity of GSCs. Figure S7: In vitro migration and invasion assays using GSCs with MET targeting. Figure S8: Immunohistochemical analysis using human nuclei-specific antibody on the sections of GBM xenografts. Figure S9: Limiting dilution sphere forming assay to determine the clonogenic potentials of 822 GSCs after treatments of radiation and SU11274
Supplementary Materials and Methods from An NMR Metabolomics Approach for the Diagnosis of Leptomeningeal Carcinomatosis
Authors: Cho Hye Rim , Wen He , Ryu Young Jin , An Yong Jin , Kim Hyo Cheol , Moon Woo Kyung , Han Moon Hee , Park Sunghyouk , Choi Seung Hong
Published: April 2023

PDF file - 164K
Supplementary Figure 6 from Acyclic Retinoid Targets Platelet-Derived Growth Factor Signaling in the Prevention of Hepatic Fibrosis and Hepatocellular Carcinoma Development
Authors: Okada Hikari , Honda Masao , Campbell Jean S. , Sakai Yoshio , Yamashita Taro , Takebuchi Yuuki , Hada Kazuhiro , Shirasaki Takayoshi , Takabatake Riuta , Nakamura Mikiko , Sunagozaka Hajime , Tanaka Takuji , Fausto Nelson , Kaneko Shuichi
Published: April 2023

PDF file - 133K, (A) Western blotting of PDGFR-o, POGFR-p, VEGFR2, p-AKT, p-ERK112 and GAPDH expression in Huh-7, HepG2, NH3T3, HLE, HUVEC and Lx-2 cells treated with peretinoin. (B) RTD-peR evaluation of collagen 1a2 in Lx-2, HLE and HUh-7 cells with or without peretinoin (20 IJM) (n=3). (C) Time course of PDGF-a, Sp1, c-Jun and p-c-Jun after peretinoin treatment in HUh-7 cells.
Supplementary Figure 4 from ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
Authors: Clegg Nicola J. , Wongvipat John , Joseph James D. , Tran Chris , Ouk Samedy , Dilhas Anna , Chen Yu , Grillot Kate , Bischoff Eric D. , Cai Ling , Aparicio Anna , Dorow Steven , Arora Vivek , Shao Gang , Qian Jing , Zhao Hong , Yang Guangbin , Cao Chunyan , Sensintaffar John , Wasielewska Teresa , Herbert Mark R. , Bonnefous Celine , Darimont Beatrice , Scher Howard I. , Smith-Jones Peter , Klang Mark , Smith Nicholas D. , De Stanchina Elisa , Wu Nian , Ouerfelli Ouathek , Rix Peter J. , Heyman Richard A. , Jung Michael E. , Sawyers Charles L. , Hager Jeffrey H.
Published: April 2023

PDF file - 185K
Supplementary Methods, Figures 1-2 from Regulation of ERBB2 Receptor by t-DARPP Mediates Trastuzumab Resistance in Human Esophageal Adenocarcinoma
Authors: Hong Jun , Katsha Ahmed , Lu Pengcheng , Shyr Yu , Belkhiri Abbes , El-Rifai Wael
Published: April 2023

PDF file - 215K, t-DARPP enhances ERBB2 expression on the cell surface Supplemental Figure 2. t-DARPP decreases binding of trastuzumab to ERBB2 receptor
Supplementary Legends for Figures 1-3, Table 1 from Targeting CD4+ T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell–Based Vaccination
Authors: Aarntzen Erik H.J.G. , De Vries I. Jolanda M. , Lesterhuis W. Joost , Schuurhuis Danita , Jacobs Joannes F.M. , Bol Kalijn , Schreibelt Gerty , Mus Roel , De Wilt Johannes H.W. , Haanen John B.A.G. , Schadendorf Dirk , Croockewit Alexandra , Blokx Willeke A.M. , Van Rossum Michelle M. , Kwok William W. , Adema Gosse J. , Punt Cornelis J.A. , Figdor Carl G.
Published: April 2023

PDF file - 43K
Supplementary Table 2 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: April 2023

PDF file - 289K, Immunostaining of Pak1 and proliferative signaling markers in SCC
Supplementary Figure Legends 1-5, Table Legends 1-3 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: April 2023

PDF file - 131K
Supplementary Figures 1-12 from Dmp1 Physically Interacts with p53 and Positively Regulates p53′s Stability, Nuclear Localization, and Function
Authors: Frazier Donna P. , Kendig Robert D. , Kai Fumitake , Maglic Dejan , Sugiyama Takayuki , Morgan Rachel L. , Fry Elizabeth A. , Lagedrost Sarah J. , Sui Guangchao , Inoue Kazushi
Published: April 2023

PDF file - 786K
Supplementary Figure Legend from SOCS3 Transactivation by PPARγ Prevents IL-17–Driven Cancer Growth
Authors: Berger Hélène , Végran Frédérique , Chikh Madijd , Gilardi Federica , Ladoire Sylvain , Bugaut Hélène , Mignot Grégoire , Chalmin Fanny , Bruchard Mélanie , Derangère Valentin , Chevriaux Angélique , Rébé Cédric , Ryffel Bernhard , Pot Caroline , Hichami Aziz , Desvergne Béatrice , Ghiringhelli François , Apetoh Lionel
Published: April 2023

PDF file - 93K
Supplementary Figure 2 from SOCS3 Transactivation by PPARγ Prevents IL-17–Driven Cancer Growth
Authors: Berger Hélène , Végran Frédérique , Chikh Madijd , Gilardi Federica , Ladoire Sylvain , Bugaut Hélène , Mignot Grégoire , Chalmin Fanny , Bruchard Mélanie , Derangère Valentin , Chevriaux Angélique , Rébé Cédric , Ryffel Bernhard , Pot Caroline , Hichami Aziz , Desvergne Béatrice , Ghiringhelli François , Apetoh Lionel
Published: April 2023

PDF file - 32K, DHA incorporates into splenic cells in vivo.
Supplementary Figure 3 from Increased CD8+ T-cell Function following Castration and Immunization Is Countered by Parallel Expansion of Regulatory T Cells
Authors: Tang Shuai , Moore Miranda L. , Grayson Jason M. , Dubey Purnima
Published: April 2023

PDF file - 1.4MB
Supplementary Table 1 from Transcription Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1α in a p53-Independent Manner
Authors: Wu Shourong , Kasim Vivi , Kano Mitsunobu R. , Tanaka Sayaka , Ohba Shinsuke , Miura Yutaka , Miyata Kanjiro , Liu Xueying , Matsuhashi Ako , Chung Ung-il , Yang Li , Kataoka Kazunori , Nishiyama Nobuhiro , Miyagishi Makoto
Published: April 2023

PDF file - 60K, Primer pairs used in this study for quantitative Real-time RT-PCR
Supplementary Figure 6 from Transcription Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1α in a p53-Independent Manner
Authors: Wu Shourong , Kasim Vivi , Kano Mitsunobu R. , Tanaka Sayaka , Ohba Shinsuke , Miura Yutaka , Miyata Kanjiro , Liu Xueying , Matsuhashi Ako , Chung Ung-il , Yang Li , Kataoka Kazunori , Nishiyama Nobuhiro , Miyagishi Makoto
Published: April 2023

PDF file - 129K, The establishment of HCT116 p53-/-/shYY1 stable cells
Supplementary Table 1 from DNA Methylation Biomarkers Offer Improved Diagnostic Efficiency in Lung Cancer
Authors: Nikolaidis Georgios , Raji Olaide Y. , Markopoulou Soultana , Gosney John R. , Bryan Julie , Warburton Chris , Walshaw Martin , Sheard John , Field John K. , Liloglou Triantafillos
Published: April 2023

PDF file - 46K, Pyrosequencing-based DNA methylation detection in the tissue validation set
Supplementary Figure Legends 1-3 from PDGF Receptor Alpha Is an Alternative Mediator of Rapamycin-Induced Akt Activation: Implications for Combination Targeted Therapy of Synovial Sarcoma
Authors: Ho Alan L. , Vasudeva Shyamprasad Deraje , Laé Marick , Saito Tsuyoshi , Barbashina Violetta , Antonescu Cristina R. , Ladanyi Marc , Schwartz Gary K.
Published: April 2023

PDF file - 64K
Supplementary Figures 1 - 3 from Cowden Syndrome-Related Mutations in PTEN Associate with Enhanced Proteasome Activity
Authors: He Xin , Arrotta Nicholas , Radhakrishnan Deepa , Wang Yu , Romigh Todd , Eng Charis
Published: April 2023

PDF file - 391K, Supplementary Figure. S1. MCF-7 cells expressing FLAG-tagged WT or missense PTEN plasmids were treated with 10μM MG132 or DMSO vehicle control for O.N. Supplementary Figure. S2. Cellular fractions of MCF-7 (A) and HEK293 cells (B) from Figure 3B&C were resolved by SDS-PAGE and probed by Western blotting with indicated antibodies. N, nuclear fraction; C, cytosolic fraction.Supplementary Figure. S3. Total RNAs from respective transfected cells were isolated and subjected to RT-PCR analysis to monitor mRNA expression of PTEN and GAPDH.
Supplementary Figure 1 from PDGF Receptor Alpha Is an Alternative Mediator of Rapamycin-Induced Akt Activation: Implications for Combination Targeted Therapy of Synovial Sarcoma
Authors: Ho Alan L. , Vasudeva Shyamprasad Deraje , Laé Marick , Saito Tsuyoshi , Barbashina Violetta , Antonescu Cristina R. , Ladanyi Marc , Schwartz Gary K.
Published: April 2023

PDF file - 73K, Viability assays quantify the percent decrease in viability achieved with rapamycin and R1507 alone or in combination in sarcoma cell lines; viability assays performed in the 12 cell line sarcoma panel
Supplementary Figure 2 from A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor
Authors: Urbanska Katarzyna , Lanitis Evripidis , Poussin Mathilde , Lynn Rachel C. , Gavin Brian P. , Kelderman Sander , Yu Jason , Scholler Nathalie , Powell Daniel J.
Published: April 2023

PDF file - 21K, BBIR-z T cells loaded with biotinylated molecules and then washed do not produce IFN�� in response to specific antigen stimulation. Following 45min incubation at 37oC with 1ug/ml of mesothelin specific biotinylated antybodies; P4 Biobody or K1 and control Bio-IgG1 antibody, BBIR-z T cells were washed with PBS and tested against plate-immobilized human mesothelin (105 cells/10ng mesothelin/well). After overnight incubation, culture supernatants were analyzed for human IFN�^ cytokine by ELISA. Concentration of IFN�� is expressed in pg/ml (means �� SEM; n = 3).
Supplementary Figure 1 from A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor
Authors: Urbanska Katarzyna , Lanitis Evripidis , Poussin Mathilde , Lynn Rachel C. , Gavin Brian P. , Kelderman Sander , Yu Jason , Scholler Nathalie , Powell Daniel J.
Published: April 2023

PDF file - 67K, Upper. CD28 co-stimulation protects against antigen-induced cell death. Annexin V and 7-AAD staining of T cells (untransduced, BBIR-z and BBIR-28z) following 72 h (grey bars) and 96 h (black bars) co-culture with A1847 at an E:T ratio 1:1, painted with either Bio-IgG1 or Bio-EpCAM antibodies. Apoptosis was quantified as a percentages of apoptotic cells- Annexin V+ and 7AAD+ (means �� SEM; n = 3). Lower. Annexin V/7-AAD assay plots showing T cells after 96 h co-culture with A1847 cell line labeled with biotinylated IgG1 (Bio-IgG1) (top panels) and biotinylated EpCAM specific (Bio-EpCAM) antybodies, at an E:T ratio of 1:1. One representative FACS analysis is shown (n=3).
Supplementary Table 3 from A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas
Authors: Nikolaev Sergey I. , Sotiriou Sotirios K. , Pateras Ioannis S. , Santoni Federico , Sougioultzis Stavros , Edgren Henrik , Almusa Henrikki , Robyr Daniel , Guipponi Michel , Saarela Janna , Gorgoulis Vassilis G. , Antonarakis Stylianos E. , Halazonetis Thanos D.
Published: April 2023

XLSX file - 457K
Supplementary Figure 1 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma
Authors: Wei Jun , Wang Fei , Kong Ling-Yuan , Xu Shuo , Doucette Tiffany , Ferguson Sherise D. , Yang Yuhui , McEnery Kayla , Jethwa Krishan , Gjyshi Olsi , Qiao Wei , Levine Nicholas B. , Lang Frederick F. , Rao Ganesh , Fuller Gregory N. , Calin George A. , Heimberger Amy B.
Published: April 2023

Supplementary Figure 1. PDF file 49K, (A) The relative expression of miR-124 as detected by TaqMan quantitative PCR in the CD11b+ GBM-infiltrating microglia/macrophages (n=4) is either very low or undetectable compared to normal brain tissues (n=3) (P < 0.01). (B) Summary dot plot demonstrating miR-124 expression is induced in gCSCs (n=8) upon neural differentiation (P < 0.01). Black filled circles: gCSCs; black filled squares: differentiated gCSCs. (C) Interleukin-8 (IL-8) (P < 0.05), galectin-3 (P < 0.01), and MIC-1 (P < 0.05) produced by gCSCs were reduced upon transfection with miR-124 compared with their levels in the scramble control
Supplementary Figure 3 from NLRR1 Enhances EGF-Mediated MYCN Induction in Neuroblastoma and Accelerates Tumor Growth In Vivo
Authors: Hossain Shamim , Takatori Atsushi , Nakamura Yohko , Suenaga Yusuke , Kamijo Takehiko , Nakagawara Akira
Published: April 2023

PDF file, 106K, Phosphorylation of Sp1 is important for its transcriptional efficiency to induce MYCN. EGF-mediated phosphorylation of Sp1 was cancelled by MEK1/2 inhibitor and dephosphorylating agent. The Sp1 inhibitor mithramycin cancels MYCN induction by EGF. Pretreatment with dephosphorylating agent CIAP cancels MYCN induction and inhibits Sp1 recruitment to the MYCN promoter upon EGF stimulation.
Supplementary Figure 2 from PNUTS Functions as a Proto-Oncogene by Sequestering PTEN
Authors: Kavela Sridhar , Shinde Swapnil R. , Ratheesh Raman , Viswakalyan Kotapalli , Bashyam Murali D. , Gowrishankar Swarnalata , Vamsy Mohana , Pattnaik Sujit , Rao Subramanyeshwar , Sastry Regulagadda A. , Srinivasulu Mukta , Chen Junjie , Maddika Subbareddy
Published: April 2023

PDF file - 32K, PNUTS is overexpressed in cancers
Supplementary Methods from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide
Authors: Jang Miran , Kim Yeonghwan , Won Hyeran , Lim Sangbin , K.R Jyothi , Dashdorj Amarjargal , Min Yoo Hong , Kim Si-Young , Shokat Kevan M. , Ha Joohun , Kim Sung Soo
Published: April 2023

PDF file - 169K
Supplementary Table 5 from Characterization of Gene–Environment Interactions for Colorectal Cancer Susceptibility Loci
Authors: Hutter Carolyn M. , Chang-Claude Jenny , Slattery Martha L. , Pflugeisen Bethann M. , Lin Yi , Duggan David , Nan Hongmei , Lemire Mathieu , Rangrej Jagadish , Figueiredo Jane C. , Jiao Shuo , Harrison Tabitha A. , Liu Yan , Chen Lin S. , Stelling Deanna L. , Warnick Greg S. , Hoffmeister Michael , Küry Sébastien , Fuchs Charles S. , Giovannucci Edward , Hazra Aditi , Kraft Peter , Hunter David J. , Gallinger Steven , Zanke Brent W. , Brenner Hermann , Frank Bernd , Ma Jing , Ulrich Cornelia M. , White Emily , Newcomb Polly A. , Kooperberg Charles , LaCroix Andrea Z. , Prentice Ross L. , Jackson Rebecca D. , Schoen Robert E. , Chanock Stephen J. , Berndt Sonja I. , Hayes Richard B. , Caan Bette J. , Potter John D. , Hsu Li , Bézieau Stéphane , Chan Andrew T. , Hudson Thomas J. , Peters Ulrike
Published: April 2023

PDF file - 52K, Further information about main finding.
Supplementary Figure 4 from RAP80 Is Critical in Maintaining Genomic Stability and Suppressing Tumor Development
Authors: Yin Zhengyu , Menendez Daniel , Resnick Michael A. , French John E. , Janardhan Kyathanahalli S. , Jetten Anton M.
Published: April 2023

PDF file - 870K, Increased chromosomal instability in RAP80-/- iMEFs after DNA damage
Supplementary Figure 3 from RAP80 Is Critical in Maintaining Genomic Stability and Suppressing Tumor Development
Authors: Yin Zhengyu , Menendez Daniel , Resnick Michael A. , French John E. , Janardhan Kyathanahalli S. , Jetten Anton M.
Published: April 2023

PDF file - 59K, Increased sensitivity of RAP80-/- MEFs to DNA damaging agents
Supplementary Figure 1 from Characterization of Gene–Environment Interactions for Colorectal Cancer Susceptibility Loci
Authors: Hutter Carolyn M. , Chang-Claude Jenny , Slattery Martha L. , Pflugeisen Bethann M. , Lin Yi , Duggan David , Nan Hongmei , Lemire Mathieu , Rangrej Jagadish , Figueiredo Jane C. , Jiao Shuo , Harrison Tabitha A. , Liu Yan , Chen Lin S. , Stelling Deanna L. , Warnick Greg S. , Hoffmeister Michael , Küry Sébastien , Fuchs Charles S. , Giovannucci Edward , Hazra Aditi , Kraft Peter , Hunter David J. , Gallinger Steven , Zanke Brent W. , Brenner Hermann , Frank Bernd , Ma Jing , Ulrich Cornelia M. , White Emily , Newcomb Polly A. , Kooperberg Charles , LaCroix Andrea Z. , Prentice Ross L. , Jackson Rebecca D. , Schoen Robert E. , Chanock Stephen J. , Berndt Sonja I. , Hayes Richard B. , Caan Bette J. , Potter John D. , Hsu Li , Bézieau Stéphane , Chan Andrew T. , Hudson Thomas J. , Peters Ulrike
Published: April 2023

PDF file - 52K, Forest plots for meta-analysis results with GxE interaction p < 0.01
Supplementary Table 2 from Hypoxia-Induced Gene Expression in Chemoradioresistant Cervical Cancer Revealed by Dynamic Contrast-Enhanced MRI
Authors: Halle Cathinka , Andersen Erlend , Lando Malin , Aarnes Eva-Katrine , Hasvold Grete , Holden Marit , Syljuåsen Randi G. , Sundfør Kolbein , Kristensen Gunnar B. , Holm Ruth , Malinen Eirik , Lyng Heidi
Published: April 2023

PDF file - 35K, Biological processes associated with ABrix
Supplementary Methods from Hypoxia-Induced Gene Expression in Chemoradioresistant Cervical Cancer Revealed by Dynamic Contrast-Enhanced MRI
Authors: Halle Cathinka , Andersen Erlend , Lando Malin , Aarnes Eva-Katrine , Hasvold Grete , Holden Marit , Syljuåsen Randi G. , Sundfør Kolbein , Kristensen Gunnar B. , Holm Ruth , Malinen Eirik , Lyng Heidi
Published: April 2023

PDF file - 35K, Creating cervical cancer specific hypoxia gene sets
Supplementary Methods 2 from Hypoxia-Induced Gene Expression in Chemoradioresistant Cervical Cancer Revealed by Dynamic Contrast-Enhanced MRI
Authors: Halle Cathinka , Andersen Erlend , Lando Malin , Aarnes Eva-Katrine , Hasvold Grete , Holden Marit , Syljuåsen Randi G. , Sundfør Kolbein , Kristensen Gunnar B. , Holm Ruth , Malinen Eirik , Lyng Heidi
Published: April 2023

PDF file - 88K, Gene sets for SAM-GS
Supplementary Figure 7 from Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
Authors: Zhang Yaqing , Morris John P. , Yan Wei , Schofield Heather K. , Gurney Austin , Simeone Diane M. , Millar Sarah E. , Hoey Timothy , Hebrok Matthias , Pasca di Magliano Marina
Published: April 2023

PDF file - 6752K, Supplemental Figure 7. Inhibition of Wnt/β-catenin signaling by Dkk1 reduces epithelial cell proliferation.
Supplementary Figure Legends 1-5 from Skin-Test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell–Based Vaccination in Metastatic Melanoma
Authors: Aarntzen Erik H.J.G. , Bol Kalijn , Schreibelt Gerty , Jacobs Joannes F.M. , Lesterhuis W. Joost , Van Rossum Michelle M. , Adema Gosse J. , Figdor Carl G. , Punt Cornelis J.A. , De Vries I. Jolanda M.
Published: April 2023

PDF file - 48K
Supplementary Figure 5 from Skin-Test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell–Based Vaccination in Metastatic Melanoma
Authors: Aarntzen Erik H.J.G. , Bol Kalijn , Schreibelt Gerty , Jacobs Joannes F.M. , Lesterhuis W. Joost , Van Rossum Michelle M. , Adema Gosse J. , Figdor Carl G. , Punt Cornelis J.A. , De Vries I. Jolanda M.
Published: April 2023

PDF file - 73K, Patient selection based on SKIL criteria: SKIL criteria are applied to select patients with immune responses meeting increasingly stringent criteria
Supplementary Figure 2 from Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
Authors: Zhang Yaqing , Morris John P. , Yan Wei , Schofield Heather K. , Gurney Austin , Simeone Diane M. , Millar Sarah E. , Hoey Timothy , Hebrok Matthias , Pasca di Magliano Marina
Published: April 2023

PDF file - 6297K, Supplemental Figure 2. Pancreatic histology in DKK1 mice on doxy; KC and KDC mice without doxy.
Supplementary Figure 3 from Skin-Test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell–Based Vaccination in Metastatic Melanoma
Authors: Aarntzen Erik H.J.G. , Bol Kalijn , Schreibelt Gerty , Jacobs Joannes F.M. , Lesterhuis W. Joost , Van Rossum Michelle M. , Adema Gosse J. , Figdor Carl G. , Punt Cornelis J.A. , De Vries I. Jolanda M.
Published: April 2023

PDF file - 71K, KLH-specific T cell responses according to SKIL classification: Regardless of the number of epitopes or the increasingly stringent criteria for TAA-specific immune responses; the levels of KLH-specific T cell responses were similar and highly variable between individuals. One-way ANOVA was used for comparison of KLH-specific T cell responses in groups of patients with increasing breadth of TAA-specific CD8+ T cell responses. Student t-test was used for comparison of KLH-specific T cell responses in groups of patients as defined by different SKIL criteria
Supplementary Data from CD24 Offers a Therapeutic Target for Control of Bladder Cancer Metastasis Based on a Requirement for Lung Colonization
Authors: Overdevest Jonathan B. , Thomas Shibu , Kristiansen Glen , Hansel Donna E. , Smith Steven C. , Theodorescu Dan
Published: April 2023

Supplementary Figures S1-S4; Supplementary Table S1.
Supplementary Figures 1-7 from Suppression of the Epithelial–Mesenchymal Transition by Grainyhead-like-2
Authors: Cieply Benjamin , Riley Philip , Pifer Phillip M. , Widmeyer Joseph , Addison Joseph B. , Ivanov Alexey V. , Denvir James , Frisch Steven M.
Published: April 2023

PDF file - 3.2MB
Supplementary Methods from Radioresistant Cancer Cells Can Be Conditioned to Enter Senescence by mTOR Inhibition
Authors: Nam Hae Yun , Han Myung Woul , Chang Hyo Won , Lee Yoon Sun , Lee Myungjin , Lee Hyang Ju , Lee Byoung Wook , Lee Hee Jin , Lee Kyung Eun , Jung Min Kyo , Jeon Hyesung , Choi Seung-Ho , Park Neung Hwa , Kim Sang Yoon , Kim Seong Who
Published: April 2023

Supplementary Methods - PDF file 168K, Additional experimental procedures, including western blot, RT-PCR, cell cycle analysis, etc. Also includes supplementary references
Supplementary Figure S5 from Radioresistant Cancer Cells Can Be Conditioned to Enter Senescence by mTOR Inhibition
Authors: Nam Hae Yun , Han Myung Woul , Chang Hyo Won , Lee Yoon Sun , Lee Myungjin , Lee Hyang Ju , Lee Byoung Wook , Lee Hee Jin , Lee Kyung Eun , Jung Min Kyo , Jeon Hyesung , Choi Seung-Ho , Park Neung Hwa , Kim Sang Yoon , Kim Seong Who
Published: April 2023

Supplementary Figure S5 - PDF file 61K, Model of cellular senescence induction in human cancer cells
Supplementary Figure S4 from Radioresistant Cancer Cells Can Be Conditioned to Enter Senescence by mTOR Inhibition
Authors: Nam Hae Yun , Han Myung Woul , Chang Hyo Won , Lee Yoon Sun , Lee Myungjin , Lee Hyang Ju , Lee Byoung Wook , Lee Hee Jin , Lee Kyung Eun , Jung Min Kyo , Jeon Hyesung , Choi Seung-Ho , Park Neung Hwa , Kim Sang Yoon , Kim Seong Who
Published: April 2023

Supplementary Figure S4 - PDF file 302K, Suppression of autophagic flux decreases survival of radioresistant AMC-HN-9 cells
Supplementary Figure Legends 1-4 from Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy
Authors: Ramakrishnan Rupal , Huang Chun , Cho Hyun-Il , Lloyd Mark , Johnson Joseph , Ren Xiubao , Altiok Soner , Sullivan Daniel , Weber Jeffrey , Celis Esteban , Gabrilovich Dmitry I.
Published: April 2023

PDF file - 74K
Supplementary Figure 3 from Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy
Authors: Ramakrishnan Rupal , Huang Chun , Cho Hyun-Il , Lloyd Mark , Johnson Joseph , Ren Xiubao , Altiok Soner , Sullivan Daniel , Weber Jeffrey , Celis Esteban , Gabrilovich Dmitry I.
Published: April 2023

PDF file - 56K, Redistribution of MPR to the cell surface after chemotherapy
Supplementary Figure 3 from A Survivin-Associated Adaptive Response in Radiation Therapy
Authors: Grdina David J. , Murley Jeffrey S. , Miller Richard C. , Mauceri Helena J. , Sutton Harold G. , Li Jian Jian , Woloschak Gayle E. , Weichselbaum Ralph R.
Published: April 2023

PDF - 186K, Representative TUNEL assay images of RKO36 apoptotic cells.
Supplementary Figure 7 from Aptamer-Mediated Blockade of IL4Rα Triggers Apoptosis of MDSCs and Limits Tumor Progression
Authors: Roth Felix , De La Fuente Adriana C. , Vella Jennifer L. , Zoso Alessia , Inverardi Luca , Serafini Paolo
Published: April 2023

PDF file - 5.9MB
Supplementary Figure 3 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Authors: Fiaschi Tania , Marini Alberto , Giannoni Elisa , Taddei Maria Letizia , Gandellini Paolo , De Donatis Alina , Lanciotti Michele , Serni Sergio , Cirri Paolo , Chiarugi Paola
Published: April 2023

PDF file - 385K, 8.Lactate up-load by HPFs and PCa-AFs; 10000 HPFs were treated with serum-free medium or with CM-PCa for 24 hours (PCa-AFs). U-14Clactate were added to the culture media for 30 minutes, then cells were lysated and incorporated radioactive lactate were measured by scintillator. The obtained values were normalized on protein content.
Supplementary Figure 5 from Aptamer-Mediated Blockade of IL4Rα Triggers Apoptosis of MDSCs and Limits Tumor Progression
Authors: Roth Felix , De La Fuente Adriana C. , Vella Jennifer L. , Zoso Alessia , Inverardi Luca , Serafini Paolo
Published: April 2023

PDF file - 6.4MB
Supplementary Figure 2 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Authors: Fiaschi Tania , Marini Alberto , Giannoni Elisa , Taddei Maria Letizia , Gandellini Paolo , De Donatis Alina , Lanciotti Michele , Serni Sergio , Cirri Paolo , Chiarugi Paola
Published: April 2023

PDF file - 3.3K, Enrichment of glycolitic enzymes among genes up-regulated in prostatic CAFs; Gene expression profiles were analyzed using an Illumina microarray platform (unpublished data) on paired CAFs and HPFs isolated respectively from the tumor and the adjacent normal tissue from three prostate cancer patients subjected to radical prostatectomy. Gene Set Enrichment Analysis (GEA) (1,2 http://broadinstitute.org/gsea)was conducted between CAFs and HPFs, and revealed, among the others, a significant enrichment for gene sets related to carbohydrate catabolism among the genes that were up-regulated in CAFs. Specifically, when the analysis was carried out searching among gene ontology gene sets (C5), enrichment was found for Carbohydrate_Catabolic_Process set, whereas and ever higher enrichment was found for a set of glycolytic enzymes (referred to as Mootha_Glycolysis) when the analysis was performed on literature based gene sets (C2). (A) Table showing normalized enrichment scores and significance for enriched gene set. (B) Enrichment plot (left) and heatmaps of gene intensities (right) for the gene set emerged from GEMSA. In the heatmaps, gene intensities are colored from blue (low expression)to red (high expression). (1) Subramanian, Tamayo et al. (2005) PNAS 102, 15545-15550 (2) Mootha, Lindgren et al. (2003) Nat Genet 34, 267-273
Supplementary Figure Legends 1-5 from CD73-Deficient Mice Are Resistant to Carcinogenesis
Authors: Stagg John , Beavis Paul A. , Divisekera Upulie , Liu Mira C.P. , Möller Andreas , Darcy Phillip K. , Smyth Mark J.
Published: April 2023

PDF file - 79K
Supplementary Table 2 from BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages
Authors: Lee Jae-Ho , Lee Geun Taek , Woo Seung Hyo , Ha Yun-Sok , Kwon Seok Joo , Kim Wun-Jae , Kim Isaac Yi
Published: April 2023

Supplementary Table 2 - PDF 42K, Multivariate Cox Analysis for the three-marker signature
Supplementary Figure 5 from Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors
Authors: Duraiswamy Jaikumar , Kaluza Karen M. , Freeman Gordon J. , Coukos George
Published: April 2023

Supplementary Figure 5 - PDF file, Lymphocyte infiltration into the tumor and lymph nodes of CT26 mice. BALB/c mice were subcutaneously injected with 0.5 x 106 CT26 tumor cells. The mice were treated i.p. with �PD-L1 and �CTLA-4 in combination on days 3, 6, 9 after tumor inoculation. TIL were analyzed by flow cytometry on day 15. Absolute numbers of CD4+CD25+Foxp3+ Tregs (i), CD8+ T cells (ii), and CD4+ Teffs (iii) per pool of lymph nodes from 12 mice (A) or per cubic millimeter of tumor (B) are shown. All data show p<0.001 according to the Mann-Whitney test
Supplementary Figure 2 from Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors
Authors: Duraiswamy Jaikumar , Kaluza Karen M. , Freeman Gordon J. , Coukos George
Published: April 2023

Supplementary Figure 2 - PDF file 42K, CT26 and ID8-VEGF tumors upregulates PD-1 and CTLA-4 ligands on tumor and myeloid cells. Expression of PD-L1, PD-L2 and B7.1 on EpCAM+ tumor cells and tumor infiltrating CD45+ myeloid cells of CT26 (A) and ID8-VEGF (B) tumors
Supplementary Figure 5 from HMGA2 Is a Driver of Tumor Metastasis
Authors: Morishita Asahiro , Zaidi M. Raza , Mitoro Akira , Sankarasharma Devipriya , Szabolcs Matthias , Okada Yasunori , D'Armiento Jeanine , Chada Kiran
Published: April 2023

PDF file - 80K, TGFBetaRII was up-regulated in 4T1 cells. TGFBetaRII mRNA expression was highly up-regulated in 4T1 cells compared to 4TO7 parental cells (## = P < 0.0001)
Supplementary Figure 4 from Fibulin-3 Promotes Glioma Growth and Resistance through a Novel Paracrine Regulation of Notch Signaling
Authors: Hu Bin , Nandhu Mohan S. , Sim Hosung , Agudelo-Garcia Paula A. , Saldivar Joshua C. , Dolan Claire E. , Mora Maria E. , Nuovo Gerard J. , Cole Susan E. , Viapiano Mariano S.
Published: April 2023

PDF file - 107K, Fibulin-3 is not a Notch target in glioma cells
Supplementary Figure 3 from Opposing Roles for IL-23 and IL-12 in Maintaining Occult Cancer in an Equilibrium State
Authors: Teng Michele W. L. , Vesely Matthew D. , Duret Helene , McLaughlin Nicole , Towne Jennifer E. , Schreiber Robert D. , Smyth Mark J.
Published: April 2023

PDF file - 79K, Anti-IL-23 and anti-IL-10R delay outgrowth of tumors caused by immune depletion
Supplementary Figure 4 from Strain-Specific Variation in Murine Natural Killer Gene Complex Contributes to Differences in Immunosurveillance for Urethane-Induced Lung Cancer
Authors: Kreisel Daniel , Gelman Andrew E. , Higashikubo Ryuji , Lin Xue , Vikis Haris G. , White J. Michael , Toth Kelsey A. , Deshpande Charuhas , Carreno Beatriz M. , You Ming , Taffner Samantha M. , Yokoyama Wayne M. , Bui Jack D. , Schreiber Robert D. , Krupnick Alexander S.
Published: April 2023

PDF file - 30K, Cytotoxicity of NK cells from C57BL/10 and Balb/c mice
Supplementary Figure from Cancer Cells Cue the p53 Response of Cancer-Associated Fibroblasts to Cisplatin
Authors: Schmid Jens O. , Dong Meng , Haubeiss Silke , Friedel Godehard , Bode Sabine , Grabner Andreas , Ott German , Mürdter Thomas E. , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 56K, Reduction of proliferation and induction of cell death upon cisplatin treatment in category I tumors and tumors of categories II and III
Supplementary Methods from The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma
Authors: Wu Juan , Li Jiaqi , Salcedo Rosalba , Mivechi Nahid F. , Trinchieri Giorgio , Horuzsko Anatolij
Published: April 2023

PDF file - 102K
Supplementary Figure 1 from Metabolic Associations of Reduced Proliferation and Oxidative Stress in Advanced Breast Cancer
Authors: Jerby Livnat , Wolf Lior , Denkert Carsten , Stein Gideon Y. , Hilvo Mika , Oresic Matej , Geiger Tamar , Ruppin Eytan
Published: April 2023

PDF file, 557K, Robustness analysis. The Spearman correlation between the MPA profiles obtained with varying � (a-b), and � (c-d) parameters. The correlations were computed per sample (a, c), and per metabolic process (b, d).
Supplementary Figure 7 from Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation
Authors: Duhamel Stéphanie , Hébert Josée , Gaboury Louis , Bouchard Amélie , Simon Ronald , Sauter Guido , Basik Mark , Meloche Sylvain
Published: April 2023

PDF file - 15.8MB