bluuebunny/crossref_metadata_2025 huggingface dataset:
El arrepentimiento en el paciente y en el clínico y la búsqueda del perdón
Authors: Bucheler Sandra
Published: April 2022

This paper explores the role of regret in psychotherapeutic treatment, which is noted as one of the most neglected areas in the theoretical literature. Then he focuses on the search for forgiveness, mercy and possible reparation. What role does the patient's need to forgive others and to be forgiven play in clinical treatment? And what about the analyst's need to forgive others and be forgiven? What are the roles of mercy and reparation in treatment, and in general in our lives? These themes are illustrated with experiences of the author.
Los sueños del mundo, una interpretación del cine desde la psicología analítica
Authors: Quiroga Maria Pilar
Published: April 2022

Analytical psychology proposes an analysis of the cinema that is completely different from other areas of psychology and very distant from the proposals of classical psychoanalysis. The difference between refers to the presence of symbolic interpretation versus semiotics, two opposing perspectives that represent radically different ways of seeing and standing before art and the world. Jungian cinematographic analysis defines the symbols as living messages constituting the cinematographic contents a kind of projected psyche. The origin of the images is located in the collective unconscious, in its archetypes, which will access consciousness from the active imagination. By experiencing the cinema, we recover images or myths that complete our personal and collective unity, stabilizing our psychic functioning and finding a kind of balance for the community. The creative process arises from the unconscious, both that of the director who creates, and that of the viewer who relives the plot, or of the actors who join the narrative with their interpretive force, all participate in the same state of connection with the unconscious contents and with the archetypal world
Study on the Coupling Effect of Microwave and Magnetic Nanoparticles on Oil Droplet Coalescence
Authors: Sun Nana , Chang Xiaohu , Sun Huina , Shen Lisha , Su Ruiyu
Published: April 2022

In this study, we first compared the demulsification laws for the different types and concentrations of magnetic nanoparticles in heavy crude oil-in-water (O/W) emulsions stabilized by the binary system of amphoteric surfactant BS-12 (the major component is dodecyl dimethyl betaine) and organic alkali triethanolamine (TEOA) with and without microwave radiation. Second, by determining the microscopic morphology, contact angle, and Zeta potential of the magnetic nanoparticles, as well as the relationship between oil droplet distribution and demulsification efficiency, the effect of magnetic nanoparticles-microwave coupling on the mechanism of oil droplet coalescence was elucidated in terms of “nonthermal effect” and “thermal effect.” The results showed that in the case of magnetic nanoparticles alone, the order of magnetic nanoparticles in terms of their effect on the demulsification efficiency was NiFe2O4 > Co3O4 > Ni > Fe3O4 > γ-Fe2O3. When the concentration of NiFe2O4 was 200 ppm, the water separation rate of the emulsion reaches the maximum value of 98.7% after 40 min. At a Ni powder concentration of 175 mg·L−1, the water separation rate reached the maximum value of 86.1% after 30 minutes. Under the coupling effect of magnetic nanoparticles and microwave, the demulsification rate and efficiency were improved, and the order of magnetic nanoparticles in terms of the effect on demulsification efficiency was Ni > NiFe2O4 > Co3O4 > Fe3O4 > γ-Fe2O3. At the NiFe2O4 concentration of 200 mg·L−1, the emulsion has a water separation rate of 128.1% in 2 minutes. When the concentration of Ni powder was 175 mg·L−1, the emulsion was completely separated from oil and water in 2 minutes, and the water separation rate was 117.3%. The interaction between magnetic nanoparticles and microwaves was related to the types and concentrations of magnetic nanoparticles. In addition, the demulsification efficiency was improved with increasing NiFe2O4 concentration, while other types of magnetic nanoparticles have optimal demulsification concentrations. The above results could be revealed from the surface morphology, hydrophobic effect, electrical neutralization, dipole polarization, and ion conduction of magnetic nanoparticles. When the magnetic nanoparticles have a large specific surface area, strong hydrophobicity, high Zeta potentials, and intense polarization, the demulsification efficiency was high, and there was a significant synergy effect between magnetic nanoparticles and microwaves. Magnetic nanoparticle-microwave coupling is a new, efficient, and environment-friendly demulsification technology. The research presented herein provides theoretical support for the popularization and application of this technology.
Fair Trade: justice and sustainability for people and the planet
Authors:   Oxfam International Fair Trade Working Group
Published: April 2022

Oxfam has been part of the global Fair Trade movement since its inception. Today, it still inspires many of our volunteers to champion just and sustainable trade. Together, we reach out to small-scale producers, workers, and grassroots social entrepreneurs. We partner with activists, communities, democratically governed producer organizations, mission-driven enterprises, and social movements to establish ethical trade approaches and advocate for a more just trade system. We believe the current trade system is far from just or sustainable. It was captured by imperialistic and colonialist forces in the past and remains, even today, under the control of the powerful and the rich to a large extent. Trade justice offers an alternative approach: one that requires shared responsibility according to everyone’s capabilities and considers (historical) privileges, as well as systemic change in the economic, gender, climate and political realms. As long as it excludes people and future generations from its welfare-creating properties, trade cannot be considered just or sustainable.
New Physics II: Spin Picture, Particle Structure, and Fundamental Interactions
Authors: Kang China
Published: April 2022

Experimental data sometimes fails to render the expected truth, such as high-speed bullets smashing into pieces on a water surface cannot verify the water’s hardness. By re-examining the essence underneath quantum phenomena and analyzing their relevance to universal classical theory, this study has thoroughly revealed the classical counterpart of spin. Subsequently, the equivalence between spin angular momentum (of energy or charge) and vorticity flux (of energy or charge) has also been unveiled, thus intuitively clarifying many abstruse physical concepts, like spin magnetic moment, virtual electron, relativistic time dilation, neutrino chirality, quark origin, and fundamental interactions (including gravitons). From now on, almost all quantum puzzles (e.g., wave-particle duality, quantum entanglement, Schrödinger’s cat) can be understood classically, just as prominent physicists such as Planck, Einstein, and Schrödinger longed for back then. This paper can be considered a blueprint of the theory of everything (TOE).
Seaweed (Gracilariopsis funicularis) biochar incorporation into goat manure-food waste vermicompost for optimized vermi-degradation and nutrient release
Authors: Katakula Asteria , Gawanab Werner , Handura Berthold , Itanna Fisseha , Mupambwa Hupenyu Allan
Published: April 2022

Vermicomposts are organic fertilizer sources that are being promoted, however their concentration of macro nutrients such as (NPK) are very low. This study therefore evaluated the biochar from seaweed ( Gracilariopsis funicularis ) incorporated into a goat manure-food waste mixture at 0% (control); 2%; 4%; 6% and 8% on compost degradation and macro-nutrient release. After 10 weeks of vermicomposting the highest pH of 9.06 was observed within the control whilst the lowest was 8.7 in the 8% treatment. The electrical conductivity showed a positive relationship with the level of biochar incorporation with the highest of 16.5 mS/cm from the 8% treatment whilst the lowest was within the control with 6 mS/cm. There were no significant differences between treatments on humification parameters, however there were significant differences on the changes of C/N ratio with the final C/N ratio of 14.4; 14.9; 16.7; 15.1 and 14.4 for the control; 2%; 4%; 6%; and 8% treatments respectively. Higher incorporation rate resulted in the higher concentration of potassium with a value of 32.3 g/kg at week 8. The final percentage change in Olsen P was 19%: 14.2%; 7.3%; 4.1% and 3.0% for the 8%; 6%; control; 4%; and 2% treatments, respectively. An optimized level of 6 to 8 % biochar incorporation ratio can be recommended. However, incorporation of G. funicularis biochar does not seem to influence changes in the vermi degradation efficiency, though it can significantly improve the macro nutrients like P, K and Mg concentrations as well as the macro element concentrations.
Human Adipose-Derived Stem Cells Delay Muscular Atrophy After Peripheral Nerve Injury in Rats
Authors: Qu Siwei , Ma Ning , Wang Weixin , Chen Sen , Wu Qi , Li Yangqun , Yang Zhe
Published: April 2022

Introduction: Muscle is often accompanied by denervation atrophy after peripheral nerve injury. Human adipose-derived stem cells (hADSCs) and platelet-rich plasma injections into a muscle after peripheral nerve injury were examined. Methods: The rats were randomly divided into 5 groups. First group rats’ sciatic nerve was exposed with untreated, others groups rats’ sciatic nerve injury model was created first. PBS, hADSCs, PRP, and a mixture of hADSCs and PRP were injected into the gastrocnemius immediately postoperatively. Quantitation of gross musculature and muscle fiber area, SFI were investigated.Results: In 4 weeks post-surgery, post hoc Bonferroni tests showed significant differences in wet weight ratios when the hADSC group, the PRP group, and the combine group were compared with the PBS group. Areas of muscle fiber were larger in the hADSC group and the combine group compared with the PBS group at 4 weeks post-surgery. Discussion: hADSCs injection may delay muscular atrophy after sciatic nerve injury in rats, and PRP injection has little effect on delayed muscular atrophy.
Quantum key agreement protocols based on multi-particle entangled states
Authors: Ji-Hong Guo , Xie Jia-Xin , Bai Ming-Qiang , Mo Zhi-Wen
Published: April 2022

Multi-particle entanglement is an important physical resource in quantum information processing, and the larger the number of particles in the entangled states, the more quantum superiority it can show in quantum communication and quantum computing. This paper proposes two quantum key agreement protocols using Ω states and six-particle entangled states. Both protocols ensure that two participants can fairly establish a final key through the measurement correlation for multi-particle entangled states. Since the protocols only use Bell measurements and Z-basis measurements, they are more easily achieved using current technology. From the perspective of security analysis, the protocols can resist participant attacks and external attacks. Finally, compared with some exising quantum key agreement protocols, our protocols can achieve higher qubit efficiency.
Adjuvant Therapy with Gemcitabine and Stereotactic Body Radiation Therapy Versus Gemcitabine Alone for Resected Stage II Pancreatic Cancer: A Prospective, Randomized, Open-label, Single Center Trial
Authors: Ma Tao , Bai Xueli , Wei Qichun , Shui Yongjie , Lao Mengyi , Chen Wen , Huang Bingfeng , Que Risheng , Gao Shunliang , Zhang Yun , Chen Wei , Wang Ji , Liang Tingbo
Published: April 2022

Background: The role of adjuvant radiation in pancreatic adenocarcinoma (PDAC) remains unclear. We aimed to investigate the efficacy of gemcitabine combined with stereotactic body radiation therapy (SBRT) as adjuvant therapy for resected stage II PDAC.Methods: In this single center randomized controlled trial, patients with stage II PDAC that underwent margin-negative resection were randomly assigned to gemcitabine-alone adjuvant chemotherapy or adjuvant SBRT followed by gemcitabine chemotherapy. The primary endpoint was recurrence-free survival (RFS). Secondary endpoints included locoregional recurrence-free survival (LRFS), overall survival (OS), and incidence of adverse events. Results: Forty patients were randomly assigned to treatment between Sep 1, 2015 and Mar 31, 2018. Of these, 38 were included in the intention-to-treat analysis (20 in gemcitabine arm and 18 in gemcitabine plus SBRT arm). The median RFS and OS were 9.70, 28.0 months in the gemcitabine arm and 5.30, 15.0 months in the gemcitabine plus SBRT arm (RFS, P = 0.53; OS, P = 0.20), respectively. The median LRFS in both arms was unreached (P = 0.81). Grade 3 or 4 adverse events were all comparable between the two arms. Evaluation of data from the first 40 enrolled patients indicated that the addition of adjuvant SBRT was not associated with either better local disease control or recurrence free survival. Conclusions: Adjuvant SBRT neither provided a survival benefit nor improved local disease control in resected stage II PDAC. Trial registration: ClinicalTrials.gov NCT02461836
Calcium intake is not associated with kidney stone: Findings From the 2015 to 2018 National Health and Nutrition Examination Survey (NHANES)
Authors: Wei Linna , Wang Xin , Zou Xiangyi , Ma Lexin , He Jinshen
Published: April 2022

Kidney stone is a common disease nowadays, whose main component is calcium oxalate. A large amount of people eagerly to supply calcium from the dietary food, however, they are still afraid of kidney stone. In addition, some patients with kidney stones are suggested to decrease the calcium intake but there are newly search which recommends to not cut down it. We wondered whether the kidney stones are associated with calcium intake in daily life. This study investigates the relation between calcium intake and kidney stone. We supposed that the calcium intake is linked to kidney stone. People, who participated in the NHANES, from 2015 to 2018, were included and they were screened by the constraints. Multi-variable logistic regression was used to assess the association between calcium intake and kidney stone, adjusting for other confounding factors. At the same time, to conduct stratification studies, we took calcium intake as a continuous variable and classification variables respectively. In the muti-variate analysis, calcium in food had no connection with kidney stone([odds ratio] 0.9999, [confidence interval] 0.9998-1.001 in model 3 which is fully adjusted. During the trend test, there was no prominent difference from calcium quality from Q1 to Q4 in those 3 models and the muti-variate analysis separated by confounding factors might affect the result according to the univariate analysis, we found there was no disparity. So, we conclude that having the history of kidney stone is no connection with calcium intake.
Physical activity during pregnancy: a review of evidence-based recommendations
Authors: Budler Leona Cilar , Budler Marko
Published: April 2022

Background: Physical activity, as a key part of healthy lifestyle, is essential to maternal and infant health. Healthcare workers should inform pregnant women about benefits of physical activity to prevent possible health issues. Those recommendations should elaborate on relevant contemporary evidence. The aim of this paper was to review evidence-based recommendations for physical activity during pregnancy.Methods: A systematic search, analysis and synthesis of conducted randomised controlled trials (RCTs) was conducted from October 2021 to February 2022 in following databases: CINAHL, ScienceDirect and Web of Science. Literature was searched using inclusion and exclusion criteria and following PRISMA recommendations. Results: Benefits for pregnant-women health and well-being were reported while performing aerobic exercise, lumbar stabilization and stretching exercise, water exercise, nerve and tendon-slip exercise, resistance training and strength training. For all exercise modalities it is recommended to perform moderate intensity activities during the whole time of pregnancy.Conclusions: This systematic literature review supplements current knowledge on physical activity of pregnant women. It is believed that physical activity has many positive outcomes on maternal and infant health. Thus, interventions in terms of exercise prescriptions are listed and suggested in an integrative model to contextualize and promote physical activity among pregnant women.
Airport Terminal Area Capacity Calculation Based on Supply and Demand Balance of Service Resources
Authors: 牟 奇锋 , Zhang Liming , Fang Ce , Li mingjie , feng xiaolei
Published: April 2022

To effectively predict the hourly capacity of the airport terminal area, i.e., to measure the maximum number of aircraft that can receive air traffic services in a sector simultaneously under the condition that the capacity is known, this study proposes a model to calculate the terminal area capacity based on the perspective of service resources. Firstly, the supply and demand relationship between the terminal area capacity and service resource consumption was analyzed based on the configuration of the terminal area route network, traffic flow characteristics and airspace safety, and security capacity requirements. Secondly, by defining a flight service probability matrix, a demand service time model and a maximum available service time model for the terminal area were developed. Based on the balance between the supply and demand of service resources, a model was constructed to forecast the capacity of the terminal area. Finally, the validity of the model was verified by simulation. The example results indicated that the difference between the limit and correction capacities obtained from the model calculations and the simulation results is lesser than 0.3 vehicles/hour. Both the results are consistent with the actual operation, thus proving the validity and reliability of the calculation model used in this study. It was also found that when the capacity is known, the model can calculate the maximum number of aircraft receiving services simultaneously within the terminal area at peak times. These findings suggest that the proposed model can provide a theoretical basis and reference for terminal area sectoring and traffic alerting.
Body Shape and Risk of Glaucoma: A Mendelian Randomization
Authors: Yuan Ruolan , Liu Kangcheng , Cai Yingjun , He Fei , Zou Jing
Published: April 2022

Background: Several observational studies have revealed a positive or negative correlation between body size (BS) and glaucoma. However, the effect of BS on glaucoma remains unclear. Therefore, we studied BS causal association with glaucoma risk using Mendelian randomization (MR).Method: The Body Size was determined through anthropometric traits (ATs), such as body mass index (BMI), waist-to-hip ratio adjusted by body mass index (WHRadjBMI), waist-to-hip ratio (WHR), and waist circumference (WC). Association of single nucleotide polymorphisms (SNPs) with each AT and glaucoma were determined individually from the aggregated data of the Genetic Investigation of Anthropometric Traits (GIANT) consortium and the FinnGen study summary data (8591 cases with glaucoma and 210,201 controls). To explore the role of BS and glaucoma, a two-sample MR analysis was performed on genome-wide association study (GWAS) data. Besides, three MR methods (inverse variance weighted [IVW], weighted median, and MR-Egger regression) were used to get the whole causal estimate for multiple instrumental SNPs.Results: The odds ratio (OR) [95%confidence interval (CI)] for glaucoma risk per 1-SD difference in BMI (OR = 1.20; 95%CI = 1.02-1.41; P = 0.03[P＞0.05/64]) was detected. However, no significant heterogeneity was observed between SNPs. Overall causal estimates were consistent between BMI and glaucoma in other two MR methods. Besides, genetically predicted WHRadjBMI (OR = 1.10; 95%CI = 0.85-1.40; P = 0.50), WHR (OR = 1.22;95%CI =0.91-1.62; P = 0.18), and WC (OR = 1.32;95%CI =1.04-1.69; P = 0.03[P＞0.05/36]) were not associated with glaucoma. Besides, sensitivity analysis did not find any other directional pleiotropy. Conclusion: The data of this study revealed that the BS, including BMI, WHR, WHRadjBMI, and WC, was not the risk factor for glaucoma.
Predictive value of the indicators of lateral and medial knee morphology for total knee arthroplasty in patients with varus knee osteoarthritis
Authors: Ma Wenru , Li Chunpu , Liu Guangzhen , Sun Shengnan , Shen Youliang , Yu Tengbo , Zhang Yi
Published: April 2022

PurposeThis study aimed to establish a predictive model to aid in patient selection and decision-making efforts regarding total knee arthroplasty (TKA).MethodsUsing data collected from our retrospective TKA database, 132 patients with varus knee osteoarthritis (153 knees) were included in the study. We focused on patients with a diagnosis of Kellgren–Lawrence (K-L) grade II in the initial stage of knee osteoarthritis (OA) and K-L grade IV with TKA at the endpoint. The interval between baseline and endpoint was defined as the remaining life of the knee joint. The following lateral and medial knee indicators were assessed using standard anteroposterior (AP) and lateral radiography: fibula height (FH), lateral plateau widening (LPW), medial proximal tibial angle (MPTA), and joint line convergence angle (JLCA) at baseline (FH0, LPW0, MPTA0, and JLCA0, respectively); FH, LPW, MPTA, and JLCA in the TKA period (FHT, LPWT, MPTAT, and JLCAT, respectively); changes in FH, LPW, MPTA, and JLCA between baseline and TKA periods (cFH, cLPW, cMPTA, and cJLCA, respectively); and rates of change in FH, LPW, MPTA, and JLCA between baseline and TKA periods (ΔFH, ΔLPW, ΔMPTA, and ΔJLCA, respectively). Multivariate linear regression analysis was performed for comparisons of indicators with the remaining life of the knee joint.ResultsRates of change in FH and LPW between baseline and TKA periods were negatively correlated with the remaining life of the knee joint (ΔFH, β = −335.901, t = −2.182, P = 0.035; ΔLPW, β = −488.516, t = −2.588, P = 0.013). There were positive correlations of ΔMPTA and ΔJLCA with risk of requiring TKA, respectively (r = −0.523 and − 0.480, respectively, all P < 0.001), but these correlations were not statistically significant in the predictive model of the remaining life of the knee joint. Other indicators were not significantly correlated with the remaining life of the knee joint (all P > 0.05).ConclusionsRates of change in FH and LPW robustly predict the risk of requiring TKA.Level of Evidence: Retrospective Study Level III
Anti-inflammatory and wound healing activity of methanol extracts of Azadirachta indica A. Juss, Lawosinia inermis L and Achyranthus aspera L in in vitro models
Authors: Nigussie Dereje , Davey Professor Gail , Legesse Belete Adefris , Fekadu Abebaw , Mekonnen Eyasu
Published: April 2022

Background
Lymphoedema is a pathological process that results from damage, infection, blockage, or genetic defects in the lymphatic system. The main causes of lower limb lymphoedema in Ethiopia are lymphatic filariasis (LF) and podoconiosis. Many natural products are being used for management of wound and inflammatory conditions in Ethiopia. Few of these products have been systematically evaluated using in vitro tests.
Objective
The objective of this study was to conduct in vitro cytotoxicity assays, anti-inflammatory, and wound healing activity tests on selected Ethiopian plant extracts.
Methods
The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate cytotoxicity of the plant extracts. For the anti-inflammatory activity, cyclooxygenase enzymes 1 (COX-1), cyclooxygenase enzymes 2 (COX-2) and 15-lipoxygenase enzyme inhibitory assay was used. Antioxidant activities were conducted using DPPH assay. Quantification of cell multiplication based on the measurement of BrdU incorporation during deoxyribonucleic acid (DNA) synthesis, was used to measure deoxyribonucleic acid (DNA) /cell proliferation.
Results
Azadirachta indica A. Juss (82%) and Lawosinia inermis L (87.6%) showed significant inhibition against COX-1 at 25 mg/ml, while Achyranthus aspera L (91.7%) and A. indica (95%) were effective in inhibiting COX-2 at the same concentration. Similarly, L. inermis L inhibited 88.8% of COX-2 at the same concentration. L. inermis (74.8%) showed the highest inhibitory activity against 15-LOX, followed by A. asper (73.1%) and A. indica (66%) at 25mg/ml. All the tested extracts showed free radical scavenging activity at 10 mg/ml. A. indica and L. inerms have shown better stimulation of human epidermal keratinocytes, with optimal stimulation observed between 2.5 mg/ml and 5 mg/ml of the extracts.
Conclusion
Plant extracts or compounds that inhibited these enzymatic inflammatory activities may contain potential drivers or templates for the development of effective anti-inflammatory drugs. Antioxidants that maintain non-toxic ROS levels in wound tissue can improve the wound healing process.
Predefined-Time Anti-Saturation Fault-Tolerant Attitude Control for Tailless Aircraft with Guaranteed Output Constraints
Authors: yu zhiong , Li Yinghui , lv maolong , Chang Jing , pei binbin
Published: April 2022

This work investigates the anti-saturation attitude tracking control for the tailless aircraft with guaranteed output constraints, in presence of uncertain inertia parameters, bounded external disturbance, and actuator faults/failures. A predefined-time adaptive backstepping attitude control scheme has been proposed, the main features of this scheme lie in (a) designing a predefined-time filter to deal with the `explosion of complexity' and singularity problem; (b) introducing a nonlinear state-dependent function to handle the asymmetric time-varying output constraints; (c) compensating for the impact of the actuator faults/failures and input saturation by a nonlinear function and bounded estimation simultaneously. Moreover, the proposed control scheme can ensure all signals in the closed-loop system converge to a residual set around the origin within a predefined time, and this time constant can be set freely by the designer, independently of initial conditions. Finally, numerical simulations have been conducted to verify the performance of the proposed predefined-time fault-tolerant control scheme.
Characteristic MRI findings of the shoulder, elbow, and wrist joints in elite wheelchair basketball players
Authors: Sakai Masafumi , Mutsuzaki Hirotaka , Shimizu Yukiyo , Okamoto Yoshikazu , Nakajima Takahito
Published: April 2022

Background
The health of wheelchair users’ upper limbs is directly related to their quality of life. In addition, para-sport athletes are subjected to a dual load on their upper extremities from competition and daily life, making it even more critical to maintain upper extremity health. This study aimed to investigate the characteristics of joint disorders in elite wheelchair basketball players using magnetic resonance imaging (MRI).
Methods
We scanned MRI images of the bilateral shoulders, elbows, and wrist joints of ten elite wheelchair basketball players and ten general wheelchair users. Two radiologists interpreted the MRI images and diagnosed the diseases of each joint. We compared the number of lesions between the two groups. We used Fisher's exact test to determine whether the lesions diagnosed by MRI were specific to wheelchair basketball players. The significance threshold was set at P < 0.05.
Results
Elite wheelchair basketball players had significantly more left-sided and bilateral latero-posterior lesions, which are cysts found on the lateral-posterior corner of the capitulum of the humerus than general wheelchair users (P < 0.05). Severe damage to the right triangular fibrocartilage complex was also observed more frequently (P < 0.05) in wheelchair basketball players.
Conclusions
We believe that the patient’s tendency to fall forward in the wheelchair hitting both hands on the ground, thereby injuring the triangular fibrocartilage complex and locking the lateral elbow, may be the cause of the characteristic findings on MRI. High-speed wheelchair operation was also thought to be a cause of severe triangular fibrocartilage complex injuries. Therefore, more attention should be paid to hand placement and wrist protection during falls. This study's insights can be useful for future solutions to extend players' careers.
Trial registration:
This paper is not a paper reporting the results of a medical intervention on human participants. That is, it is not a report of a clinical trial.
Impact of Chief Executive Officers (CEO) Duality on Financial Performance of Commercial Banks in Ethiopia
Authors: Gebrayes Workinesh Kebede , Edeit Addisu Gemeda
Published: April 2022

The main objective of this study is to examine the relationship between the Chief Executive Officer (CEO) duality and the financial performance of commercial banks in Ethiopia. 12 commercial banks are included in this study among 17 banks in Ethiopia based on their financial report of 10 years for the period of 2009 to 2018. Five banks have not been included in the sample selection since one bank is a development bank and the other four commercial banks are newly established. The secondary data have been accrued from the National Bank of Ethiopia with banks' financial performance and primary data have been gathered from selected commercial banks using survey questionnaires concerning corporate structure. It uses panel data on financial performance measured by Return on Equity (ROE), Return on Asset (ROA), and Net Interest Margin (NIM). To analyze data E-View 9 Statistics was used. Both multiple regression and correlation were used to determine the relationship between the Chief Executive Officers (CEO) duality and financial performance of commercial banks in Ethiopia. The study investigated that half of the banks chief executive officers hold the position of chairman The correlation result indicate that Chief Executive Officer (CEO) duality has a positively and statistically insignificant relationship with the financial performance of commercial banks as measured by Return on Equity (ROE) (0.013), there is a negative relationship between Chief Executive Officers (CEO) Duality (-0.231) and the financial performance as measured by Return on Assets (ROA). There is a negative relationship between Chief Executive Officer (CEO) duality (-0.043) and the financial performance as measured by Net Interest Margin (NIM).
Impact of APOE ε3 and ε4 genotypes on plasma proteome signatures in Alzheimer's disease
Authors: Kaur Gurjeet , Poljak Anne , Masters Colin L , Fowler Christopher , Sachdev Perminder
Published: April 2022

Background: The ε4 allele of the apolipoprotein E (APOE) gene is a high-risk factor for Alzheimer's disease (AD). However, approximately 25%–40% of patients with AD do not carry the APOEe4 allele, and the pathophysiological mechanisms underlying AD are less evident in these individuals. The main objective of this study was to understand the changes in plasma that may contribute to disease pathogenesis in AD and how APOEe3 and APOEe4 contribute to plasma biomarker profiles in AD.Methods: We conducted an in-depth plasma proteomics analysis using intensive depletion of high-abundant plasma proteins with Agilent multiple affinity removal liquid chromatography (LC) column- Human 14 (Hu14) followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS PAGE) technique coupled with Q-Exactive Plus mass spectrometer (Thermo Electron, Bremen, Germany). Two search engines were used to analyze the raw files, including ProteomeDiscoverer v2.4 (Thermo Fisher Scientific, Waltham, MA) and Scaffold Q+ software v 4.11.0 (Proteome Software, Portland).Results: In our study, we have expanded the depth of plasma proteome coverage to reveal new differentially expressed proteins (DEPs) that correlated with AD pathogensis. The identification of 134 proteins in AD APOEε3 relative to ε3 controls and 71 in AD APOEε4 relative to ε4 controls are reported in this study. Mainly signature proteins identified were associated with molecular functions including complement cascade, glycolysis, metabolism, plasma lipoprotein assembly, remodeling, and clearance. Here, we have shown a list of proteins such as MB, GPI and PKM reflecting the biochemical changes that are associated with pathogenesis of AD despite the APOE genotypes. The increase plasma proteome depth allowed us to identify a large number of proteins which are previously reported in brain tissue or cerebrospinal fluid in AD cohorts are likely much stronger candidates for future validation work.Conclusion: This study performed an in-depth proteome analysis to identify plasma proteome signatures associated with APOEε3 and APOEε4 genotypes. Further analysis of proteome correlation with APOE genotpyes will yield clinically meaningful information into the biological basis of AD.
Robot Grasping in Random Scenarios Based on hybrid optimization algorithm (MR-GPD)
Authors: Zhnag Songsong , huang Haisong
Published: April 2022

Robot grasping technology is favored by scientific researchers because of its importance in the field of robotics and its prospects. The main challenge of robotic grasping is to design an effective grasping detection algorithm for accurate grasping of the robot. Recently, various robotic grasping techniques have been proposed to improve the grasping performance of the robot. However, for random objects in an unstructured environment, even if accurate target classification is performed, multiple targets may overlap, which leads to a decline in the grasping performance of many robot grasping methods and cannot meet the accuracy requirements. To solve this problem, we propose an innovative grasping detection algorithm, which we call MR-GPD. MR-GPD is based on the robot grasping gesture detection algorithm (GPD), embeds the Mask-RCNN deep learning model to classify and segment the grasped target, then combine the results of target segmentation to construct a grasping candidate screening mechanism to evaluate and filter the outputted grasping candidates, and retain the best grasping candidate plan in the planned grasping task. To meet the requirements of the robots actual grasping task, an improved Mask-RCNN neural network model is proposed, the speed and accuracy of target segmentation in the actual grasping process of the robot are improved, and the accuracy of the model reaches 97.5%. In this article, we conducted experimental evaluations through experimental tests and Baxter robots. The experimental results show that the method has a good grasp effect on randomly placed objects in unstructured environment, and the average success rate is about 91.2%, it reveals the feasibility of our proposed MR-GPD method, which is expected to provide important information for robot grasping in unstructured environment.
Polydopamine-assisted in situ growth of AgNPs on face masks for the detection of pesticide based on surface-enhanced Raman scattering spectroscopy
Authors: Wang Tongtong , Zhang Qijia , Li Jia , Xu Guangda , Guo Na , Song Peng , Xia Lixin
Published: April 2022

Thiram is used as a fungicide and insecticide in agriculture to prevent white rot and anthracnose, but it also produces certain pesticide residues that endanger human health. Polydopamine (PDA) is an adhesive polymer that functionalizes almost all chemical materials, having been inspired by the adhesive properties of catechol and amines in mussel adhesive protein. In this work, we have fabricated a highly sensitive face mask (FM)-based surface-enhanced Raman scattering (SERS) substrate by depositing silver nanoparticles (AgNPs), using a PDA layer as an interface to promote adhesion. Face masks are currently ubiquitous, and are simple and easy to obtain, and this approach can be regarded as waste utilization. FM/PDA/AgNPs can detect Nile Blue A (NBA) probe molecules at concentrations as low as 1.0 × 10− 9 M, and permit measurements with sensitivity and uniformity. The Raman substrate can be used to swab the surface of fruit to detect thiram at concentrations as low as 1.0 × 10− 7 M, and the reproducibility has been assessed. The simple utilization of this flexible SERS substrate holds promise for its practical application in the field of pesticide control.
Research on the configuration paths of Sustainable Marine Eco-Efficiency: Based on fuzzy-set qualitative comparative analysis of 11 coastal areas in China
Authors: Zhenyu Huang
Published: April 2022

Studying the sustainable configuration path of marine ecological efficiency (MEE) is significant for China's efforts to build a marine power and achieve high-quality development of the marine economy. The existing studies have deficiencies in explaining the complex interaction among multiple land-based influence factors on MEE. Based on the Technology-Organization-Environment (TOE) framework and combined with the characteristics of government behavior under the background of the Chinese system, this study puts forward an integrated analysis framework to understand the differences in MEE among different coastal areas. Taking 11 coastal areas in China as cases, the fuzzy-set qualitative comparative analysis (fsQCA) method is used for configuration analysis, and the findings are as follows: (1) Conditions derived from technology, organization, and environment cannot, on their own, constitute the necessary conditions for high or low MEE, indicating that a single condition has limited explanatory power on MEE.(2) There are three configuration paths for high MEE: a path of development based on innovation, a path of ecological industry based on unique geographical location, and a path of development based on political pressure. Among them, the path of development based on innovation plays a more important role in improving MEE and has more value in making effective policy. (3) There are two ways to have a low MEE: one with a lot of innovation elements and another with a lot of environmental regulation and political pressure on the technology. These two paths imply that the lack of green technology capability is an important conditional variable for low MEE. The findings of this study will help people understand MEE's long-term development path in a more rational way and give them useful practical advice.
Auction-based location-aware task offloading strategy in edge cloud environment
Authors: Pei Cui , Fan Guisheng , Yu Huiqun , Yue Yiming
Published: April 2022

With the advent of 5G high-bandwidth and low-latency era, mobile data traffic has exploded. Most of the current researches on task offloading in edge cloud environments mainly focuses on minimizing latency, energy consumption and cost.But problems such as resource supply and demand relationship in the actual cloud market, participants’ malicious competition behavior and task mobility will affect the actual offloading results, and the security of the offloading process cannot be guaranteed. Therefore , an Auction Based Location-aware Task Offloading (ABLTO) strategy is proposed, which uses the combined double auction model to meet users’ needs for various types of resources. Then the buyer sorts according to its bid density, and the seller is ranked according to the authenticity of its bid and the distance from the buyer, and incentive/punishment measures are set to encourage the seller to deliver in good faith. The auction is deployed in the smart contract to ensure the authenticity and reliability of the process. Finally, the authenticity, fairness and economic benefits of the strategy are verified through simulation experiments.
Survival of Lactobacillus reuteri UBLRu-87 during passage through the unique in vitro gut model system
Authors: Ahire J. J. , Mokashe N. U. , Kashikar M. S. , Madempudi R. S.
Published: April 2022

In this study, the survival of Lactobacillus reuteri UBLRu-87 during passage through the unique in vitro gut model system was investigated. The viability of strain with and without glucose in GIT was determined by using pour plate and flow cytometer analysis. Lactic acid (D- and L-) production and residual glucose levels were measured as indicators of metabolic activity. In results, as per the plate count method, bacterial survival remained 100 % at 2 h of stomach phase (with and without glucose). Later at 3 h of intestinal phase, it reduced to 52 % with glucose and 100 % without glucose. At 24 h of colonic incubation, viability increased to 143 %, where bacteria utilized ~ 54% of glucose and produced 7.73 ± 0.70 mmol/L L-lactic acid and 0.22 ± 0.01 mmol/L D-lactic acid. In the absence of glucose, strain count was increased from zero to 4.95 ± 0.10 log10 CFU/mL at 24 h of colon incubation. In flow cytometer analysis, the survival of strain at 2 h of stomach phase was 109 % with glucose and 105 % without glucose. Later, it reduced to 74 % at 3 h of the intestinal phase (with and without glucose). At the end of the 24 h colonic incubation, the bacterial viability was increased to 111 % with glucose and 108 % without glucose. In conclusion, under harsh intestinal conditions without glucose, UBLRu-87 cells lose their ability to grow and multiply, but keep a viable but non-culturable (VBNC) state. After favorable conditions in colon, strain VBNC state resuscitate to culturable state. Besides this, glucose favors strain protection and viability enhancing effects during passage of strain throughout the GIT.
Rhein Promotes the Proliferation of Keratinocytes by Targeting Oestrogen Receptors for Skin Ulcer Treatment
Authors: Xu Ning , Chen Yuanran , Guo Dongjie , Deng Yu , Guo Wanjun , Liu Xin , Wang Yi , Lu Hanzhi , Zhu Jianyong , Li Fulun
Published: April 2022

Background
The Sheng-ji Hua-yu (SJHY) formula is a quite effective Traditional Chinese Medicines (TCM) in the treatment of delayed diabetic wounds. Previous research has shown that the SJHY formula has significant anti-inflammatory and wound-healing effects, but the precise mechanism remains unknown. The purpose of this study was to evaluate the effects of rhein, a compound extracted from SJHY formula, in keratinocytes and to investigate the underlying mechanisms.
Methods
Microscale thermophoresis (MST) technology was used to confirm that rhein binds directly to oestrogen receptors (ERs). Rhein was then used to treat keratinocytes in vitro. Cell cycle and proliferation analysis, Real-time polymerase chain reaction (RT-PCR) and Western-blot were conducted.
Results
Rhein increased the proportion of cells in the S phase of the cell cycle and promoted keratinocyte proliferation. ICI 182780, an ER inhibitor, was also used to treat keratinocytes. The expression of c-myc mRNA and protein induced by rhein was antagonized by ICI 182780, indicating that this induction is ER dependent. Intervention with ICI 182780 had no effect on the upregulation of FosB and JunD, indicating that activator protein 1 (AP-1) members (FosB and JunD) are involved in rhein-induced c-myc mRNA and protein expression but does not require the ER.
Conclusion
The present study found that rhein stimulates keratinocyte proliferation by activating the oestrogen signalling pathway via the oestrogen receptor, which induces the expression of c-myc in collaboration with FosB and JunD, thereby accelerating the process of re-epithelialization.
Use of ketamine in patients with refractory severe asthma exacerbations: systematic review of prospective studies.
Authors: Via Luigi La , Sanfilippo Filippo , Cuttone Giuseppe , Dezio Veronica , Falcone Monica , Brancati Serena , Crimi Claudia , Astuto Marinella
Published: April 2022

Background: Asthma is a heterogeneous disease with wide range of symptoms. Severe asthma exacerbations (SAEs) are characterized by worsening symptoms and bronchospasm requiring emergency department visits. In addition to conventional strategies for SAEs (inhaled β-agonists, anticholinergics, and systemic corticosteroids), another pharmacological option is represented by ketamine. Objective: To explore the role of ketamine in refractory SAEs.Methods: We performed a systematic search on PubMed and EMBASE up to August 12th, 2021. We selected prospective studies only, and outcomes of interest were: oxygenation/respiratory parameters, clinical status, need for invasive ventilation and effects on weaning.Results: We included a total of seven studies, five being randomized controlled trials (RCTs, population range 44-92 patients). The two small prospective studies (n=10 and n=11) did not have a control group. Four studies focused on adults, and three enrolled a pediatric population. We found large heterogeneity regarding sample size, age and gender distribution, inclusion criteria (different severity scores, if any) and ketamine dosing (bolus and/or continuous infusion). Of the five RCTs, three compared ketamine to placebo, while one used fentanyl and the other aminophylline. The outcomes evaluated by the included studies were highly variable. Despite paucity of data and large heterogeneity, an overview of the included studies suggests absence of clear benefit produced by ketamine in patients with refractory SAE, and some signals towards side effects. Conclusions: Our systematic review does not support the use of ketamine in refractory SAE. A limited number of prospective studies with large heterogeneity was found. Well-designed multicenter RCT are desirable.
Comparison of the Effects of Digoxin and Bevacizumab on Oxygen-Induced Retinopathy Rat Model
Authors: Balbaba Mehmet , Güler Seda Duran , Ulaş Fatih , Yıldırım Hakan , Canleblebici Mehmet , İncili Canan Akdeniz
Published: April 2022

Purpose: To evaluate the effect of digoxin on oxygen-induced retinopathy (OIR) model and compare the results with bevacizumab treatment.Methods: Twenty-eight newborn Sprague-Dawley rats were randomly divided into four groups:control group, normoxia+intraperitoneal (ip) normal saline (NS); OIR group, OIR+ip NS; OIR+digoxin group, OIR+ip 0.1 mg/kg of digoxin; and OIR+bevacizumab group, OIR+ip 2.5 mg/kg of bevacizumab. The rats were exposed to 50% oxygen for 24 h, followed by 10% oxygen for 24 h, to induce OIR. This cycle was repeated seven times until 14 days postnatal (P). In all groups, single-dose injections were administered on P15th day. Histopathological and immunohistochemical examinations were performed at the end of the study. Results: The mean neovascular cell nuclei counts (NVCN) of the four groups were 9.00±3.16, 41.80±11.44, 19.38±2.20, and 16.00±2.62. The mean NVCN count was significantly reduced in the treatment groups compared to the OIR group (p<0.001). The mean NVCN count was similar between the treatment groups (p=0.078). In immunohistochemical staining, the immunoreactivity values of the vascular endothelial growth factor (VEGF) were 0.01±0.00, 1.65±0.30, 0.09±0.08, and 0.04±0.02, and the tumor necrosis factor alpha (TNF-α) values were 0.10±0.00, 1.12±0.18, 0.18±0.13, and 0.14±0.05. In the OIR group, VEGF and TNF-α immunoreactivity increased markedly compared to the control group (p<0.001). VEGF and TNF-α immunoreactivity of the treatment groups decreased significantly compared to the OIR group (p<0.001). VEGF and TNF-α immunoreactivity were similar between the treatment groups (VEGF:p=0.752; TNF-α:p=0.099).Conclusions: Retinal neovascularization was significantly suppressed by digoxin treatment, and this effect was comparable to bevacizumab in the OIR model.