bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of phytate on crystallization on ureteral stents and bacterial attachment: an in vitro study
Authors: Calvó Paula , Mateu-Borras Margalida , Costa-Bauza Antonia , Albertí Sebastián , Grases Fèlix
Published: September 2022

The use of double J ureteral stents can lead to several adverse effects, as urinary infection. Bacteria tend to colonize the stent surface, leading to the formation of bacterial biofilms. The presence of urease-producing bacteria increase the urine pH leading to the incrustation and blockage of the stent. On the other hand, these large crystalline masses function as niduses, allowing the attachment of even more bacteria and decreasing its exposure to antibiotics. The aim of this in vitro study was to assess the effect of phytate on the attachment of bacteria to the catheter surface under conditions that favor crystallization. Catheter sections were incubated in a synthetic urine medium (pH 6.5) in the presence or absence of Pseudomonas aeruginosa and phytate. Amount of calcium deposits was measured using an Arsenazo III colorimetric method and the number of attached bacteria to the stent was determined. Differences were assessed using an ANOVA with a Bonferroni post hoc test. The formation of calcium phosphate deposits (brushite and hydroxyapatite) and oxalate crystals (COM), as were as the amount of bacteria decreased when phytate was present. Thus, phytate successfully decreased bacterial adhesion by inhibiting the formation of crystalline deposits.
Percutaneous treatment of chest wall chondroid hamartomas: the experience of a single center
Authors: Inserra Alessandro , Martucci Cristina , Cassanelli Giulia , Crocoli Alessandro , Paolantonio Guglielmo , Gregori Lorenzo M. , Natali Gian Luigi
Published: September 2022

Background

Thoracic mesenchymal hamartomas are rare benign lesions. Rarely symptomatic, they may compress pulmonary parenchyma, leading to respiratory distress. Although spontaneous regression has been documented, the more common outcome is progressive growth. The treatment of choice is en bloc excision of the involved portion of the chest wall, frequently leading to significant deformity.

Objective

The aim of our study was to describe percutaneous techniques to treat these lesions.

Materials and methods

We collected data of children with thoracic mesenchymal hamartomas who were treated at our institution from 2005 to 2020 using various percutaneous techniques. Techniques included radiofrequency thermoablation, microwave thermoablation (microwave thermoablation) and cryoablation.

Results

Five children were treated for chest wall hamartomas; one child showed bilateral localization of the mass. Two children underwent microwave thermoablation, one radiofrequency thermoablation and two cryoablation; one child treated with cryoablation also had radiofrequency thermoablation because mass volume increased after the cryoablation procedure. The median reduction of tumor volume was 69.6% (24.0–96.5%). One child treated with microwave thermoablation showed volumetric increase of the mass and underwent surgical removal of the tumor. No major complication was reported.

Conclusion

Percutaneous ablation is technically feasible for expert radiologists and might represent a valid and less invasive treatment for chest wall chondroid hamartoma, avoiding skeletal deformities.
Poor reproductive success of polygynously mated female birds with obligatory bi-parental care: a result of deceptive behaviour of males?
Authors: Kujala Inga , Pöysä Hannu , Korpimäki Erkki
Published: September 2022

Social polygyny usually benefits males by increasing the number of offspring, whereas it is detrimental for females as they must share the resources provided by their mate. An intersexual conflict may exist in animals with obligatory bi-parental care, such as birds of prey, in which females incubate and brood, whereas males provision food for their families. Long-term ringing data from Eurasian kestrels (Falco tinnunculus) breeding in nest-boxes and data on density indices of main prey animals (voles) were collected during 1985–2013 in western Finland to study polygynous behaviour. Of 1294 males, 54 (4.2%) were encountered at two (53) or three (1) nests during the same breeding season. Polygyny occurred more frequently during years of high vole abundance. The distances between nests of corresponding primary and secondary females were greater (median 1010 m) than the distances from nests of primary females to the nearest vacant nest-box (median 455 m). Twenty-eight (53%) of 53 secondary females had nearest available monogamous male within 2 km from their nest-boxes, indicating that mating options were available. Secondary females produced 30% less fledged offspring than simultaneously laying monogamously paired females. The abundance of prey animals is apparently alleviating the effort of males mating with multiple females. Spacing out the nests of primary and secondary females implies deceptive behaviour in the nest-site selection of polygynous males. Contradicting the polygyny threshold model, reproductive success of secondary females was significantly reduced in comparison to monogamous females laying simultaneously. These results show that secondary kestrel females apparently made a maladaptive choice, likely because they were deceived to accept polygynous mating status during the courtship feeding period.

Significance statement

As dedicated parental effort of both the male and the female is vital to ensure the offspring survival amongst animals with obligatory bi-parental care, polygyny should be inherently a maladaptive mating strategy for females. However, regular social polygyny has been documented in at least 10% of bird species from ten orders. Previous studies on breeding success of polygynous birds of prey indicate reduced offspring production of secondary female partners with no apparent cause for females to choose polygynous males over other mating options. We showed that polygyny in Eurasian kestrels is frequent when food is abundant facilitating males to provision their two or more females during courtship feeding. Polygynous males space out their two nests thus attempting to hide their mating status from their secondary partners which suffer from their mate choice in form of poor reproductive success. Therefore, amongst the “cost of polygyny to females” hypotheses, the deceptive behaviour of males during courtship feeding appeared to be an apparent explanation for maladaptive mate choice of secondary females.
The late Holocene introduction of Juglans regia (walnut) to Cyprus
Authors: Pound Matthew J. , Hazell Calian J. , Hocking Emma P.
Published: September 2022

The island of Cyprus has a long history of human impacts, including the introduction of more than 250 plant species. One of these introduced species is Juglans regia (walnut), which is considered a naturalised non-native (introduced in last 500 years). Here we report the earliest occurrence of Juglans regia pollen grains from a sedimentary deposit on Cyprus. The pollen recovered from the Akrotiri Marsh provides an earliest introduction date of 3,100-3,000 cal yr bp. This Bronze Age occurrence of Juglans regia is sporadic. However, by 2,000 cal yr bp the pollen signal becomes more persistent and indicates that introduction or expansion of Juglans regia was highly likely in the Roman period. We integrate our new results with younger pollen occurrences of Juglans regia on Cyprus, the archaeobotanical record and documentary evidence to provide an overview of this archaeophyte. Our findings show that, following the conventions of the Flora of Cyprus, Juglans regia should be reclassified from naturalised non-native to indigenous.
Ilmenite and magnetite microfabrics in shocked gneisses from the Vredefort impact structure, South Africa
Authors: Dellefant Fabian , Trepmann Claudia A. , Gilder Stuart A. , Sleptsova Iuliia V. , Kaliwoda Melanie , Weiss Benjamin P.
Published: September 2022

We investigated microfabrics of shocked Archean gneisses from two, 10 m-deep drill cores located near the center of the Vredefort impact structure in an area that is characterized by a prominent, long-wavelength negative magnetic anomaly (< − 3000 nT) together with short-wavelength, high-amplitude anomalies attributed to lightning strikes. Planar fractures and feather features in quartz, which can be partially recrystallized, indicate shock conditions less than 20 GPa. Micrometer-sized magnetite and ilmenite along shock-related shear fractures in quartz and feldspar emanate from adjacent deformed coarse (> 100 µm) ilmenite and magnetite host grains. These fine-scaled veins suggest mobilization of magnetite and ilmenite during shear deformation of host Fe-phases and adjacent silicates, probably associated with frictional heating. Coarse ilmenite has fine-lamellar mechanical twins parallel to {10$$\overline{1}$$

1
¯

1} and single (0001) twins, indicative of dislocation-glide-controlled deformation under non-isostatic stresses related to shock. A few µm-wide magnetite lamellae parallel to {10$$\overline{1}$$

1
¯

1} and spheroidal magnetite (diameter ≈10 µm) within coarse ilmenite document exsolution after shock. Dauphiné twins associated with planar features in quartz imply cooling from 650 to 725 °C after shock, which accords with estimates of pre-impact basement temperatures from petrographic studies. The Curie temperature of magnetite is 580 °C; therefore, the central negative magnetic anomaly was produced as a thermoremanent magnetization acquired during cooling of the initially hot crust. The long-wavelength anomaly was likely amplified by the newly created magnetite that also acquired a thermal remanence. Although the magnetic properties of surface samples are often influenced by lightning strikes, we found no microstructural evidence for lightning-related processes.
Difference-form group contests
Authors: Cubel María , Sanchez-Pages Santiago
Published: September 2022

This paper is the first to study difference-form group contests, that is, contests fought among groups where their probability of victory depends on the absolute difference of their effective efforts. We show that key equilibrium variables in these contests can be expressed as a function of a modified version of the Watts poverty index. We use the properties of this index to study the impact of heterogeneity, both within and between groups. In the case of homogeneous groups, we show that multiple groups can be active in equilibrium and that more groups are active and aggregate effort is higher the more similar their valuations of victory are. We then characterize equilibria under heterogeneous groups. We show that within-group heterogeneity is typically detrimental to the success of a group in the contest. Groups may have an incentive to become more homogeneous in order to increase their chances of victory.
Autologous adipose-derived stromal vascular fraction and platelet concentrates for the treatment of complex perianal fistulas
Authors: Tutino R. , Di Franco S. , Massani M. , Bonventre S. , Mazzola G. , Lo Re G. , Gulotta E. , Kamdem Mambou L. J. , Stassi G. , Cocorullo G. , Gulotta G.
Published: September 2022

Background

Complex perianal fistulas are a major challenge for modern surgery since 10–35% of patients have functional problems after treatment. Sphincter-saving techniques have a wide range of efficacy (10–80%). We hypothesised that autologous adipose-derived stromal vascular fraction in combination with platelet rich plasma is a new therapeutic strategy with enhanced cure and function preservation rates.

Methods

Adult patients with complex cryptoglandular perianal fistulas were treated with injection of autologous adipose-derived stromal vascular fraction in combination with platelet rich plasma around and inside the fistulous tract between May 2018 and April 2019 at the General and Emergency Surgery Operative Unit of the University Hospital “P. Giaccone” of Palermo. Fistulas were confirmed by magnetic resonance imaging. Patients completed the Short Form-36 score on quality of life and the Wexner and Vaizey scores on faecal incontinence, and they were functionally studied using a three-dimensional anorectal manometry. The clinical and functional follow-up was performed at 1 year and 2 years after surgery.

Results

Nine patients (4 males, 5 females; median age 42 years [19–63 years]) with high trans-sphincteric or horseshoe fistulas were treated. The average number of previous surgeries per patient was 4.8. At 1 year follow-up, 77.7% of patients were cured, while at 2 years there was 1case of relapse. The variation in Short Form-36 score in cured patients was not significant (p = 0.0936). No statistically significant differences were found in continence scores.

Conclusions

The proposed treatment is a treatment option that preserves sphincter integrity and function, potentially avoiding postoperative incontinence and the need of repeated treatments.
Effect of neuromuscular reversal with neostigmine/glycopyrrolate versus sugammadex on postoperative ileus following colorectal surgery
Authors: Traeger L. , Hall T. D. , Bedrikovetski S. , Kroon H. M. , Dudi-Venkata N. N. , Moore J. W. , Sammour T.
Published: September 2022

Background

Postoperative ileus (POI) is a common complication following colorectal surgery and is mediated in part by the cholinergic anti-inflammatory pathway (CAIP). Neostigmine (acetylcholinesterase inhibitor), co-administered with glycopyrrolate, is frequently given for neuromuscular reversal before tracheal extubation and modulates the CAIP. An alternative reversal agent, sugammadex (selective rocuronium or vecuronium binder), acts independently from the CAIP. The aim of our study was to assess the impact of neuromuscular reversal agents used during anaesthesia on gastrointestinal recovery.

Methods

Three hundred thirty-five patients undergoing elective colorectal surgery at the Royal Adelaide Hospital between January 2019 and December 2021 were retrospectively included. The primary outcome was GI-2, a validated composite measure of time to diet tolerance and passage of stool. Demographics, 30-day complications and length of stay were collected. Univariate and multivariate analyses were performed.

Results

Two hundred twenty-four (66.9%) patients (129 [57.6%] males and 95 [42.4%] females, median age 64 [19–90] years) received neostigmine/glycopyrrolate and 111 (33.1%) received sugammadex (62 [55.9%] males and 49 [44.1%] females, median age 67 [18–94] years). Sugammadex patients achieved GI-2 sooner after surgery (median 3 (0–10) vs. 3 (0–12) days, p = 0.036), and reduced time to first stool (median 2 (0–10) vs. 3 (0–12) days, p = 0.035). Rates of POI, complications and length of stay were similar. On univariate analysis, POI was associated with smoking history, previous abdominal surgery, colostomy formation, increased opioid use and postoperative hypokalaemia (p < 0.05). POI was associated with increased complications, including anastomotic leak and prolonged hospital stay (p < 0.001). On multivariate analysis, neostigmine, bowel anastomoses and increased postoperative opioid use (p < 0.05) remained predictive of time to GI-2.

Conclusions

Patients who received sugammadex had a reduced time to achieving first stool and GI-2. Neostigmine use, bowel anastomoses and postoperative opioid use were associated with delayed time to achieving GI-2.
Field surveys of September 2018 landslide-generated waves in the Apporo dam reservoir, Japan: combined hazard from the concurrent occurrences of a typhoon and an earthquake
Authors: Heidarzadeh Mohammad , Miyazaki Hiroko , Ishibe Takeo , Takagi Hiroshi , Sabeti Ramtin
Published: September 2022

We report and analyze a case study of landslide-generated waves that occurred in the Apporo dam reservoir (Hokkaido, Japan) culminating from the rare incident of hazard combination from the September 2018 Typhoon Jebi and Hokkaido earthquake (Mw 6.6 on 5 September 2018). The typhoon and earthquake were concurrent and produced thousands of landslides in the area by the combined effects of soil saturation and ground acceleration. Here, we report the results of our field surveys of the landslides that occurred around the Apporo dam and generated damaging waves in the reservoir. We identified six landslides at a close distance to the dam body; the largest one has a length of 330 m, a maximum width of 140 m and a volume of 71,400 m3. We measured wave runup at a single point with height of 5.3 m for the landslide-generated wave in the reservoir and recorded the damage made to the revetments at the reservoir banks. By considering the locations of the landslides and their potential propagation paths, we speculate that possibly three of the six surveyed landslides contributed to the measured wave runup. The surveyed runup was reproduced by inputting landslide parameters into two independent empirical equations; however, other independent empirical relationships failed to reproduce the observed runup. Our field data from the Apporo dam can be used to improve the quality of predictions made by empirical equations and to encourage further research on this topic. In addition, our field data serves as a call for strengthening dams’ safety to landslide-generated waves in reservoirs.
Short-time implied volatility of additive normal tempered stable processes
Authors: Azzone Michele , Baviera Roberto
Published: September 2022

Empirical studies have emphasized that the equity implied volatility is characterized by a negative skew inversely proportional to the square root of the time-to-maturity. We examine the short-time-to-maturity behavior of the implied volatility smile for pure jump exponential additive processes. An excellent calibration of the equity volatility surfaces has been achieved by a class of these additive processes with power-law scaling. The two power-law scaling parameters are $$\beta $$
β
, related to the variance of jumps, and $$\delta $$
δ
, related to the smile asymmetry. It has been observed, in option market data, that $$\beta =1$$

β
=
1

and $$\delta =-1/2$$

δ
=
-
1
/
2

. In this paper, we prove that the implied volatility of these additive processes is consistent, in the short-time, with the equity market empirical characteristics if and only if $$\beta =1$$

β
=
1

and $$\delta =-1/2$$

δ
=
-
1
/
2

.
A Cartesian Immersed Boundary Method Based on 1D Flow Reconstructions for High-Fidelity Simulations of Incompressible Turbulent Flows Around Moving Objects
Authors: Giannenas Athanasios E. , Bempedelis Nikolaos , Schuch Felipe N. , Laizet Sylvain
Published: September 2022

The aim of the present numerical study is to show that the recently developed Alternating Direction Reconstruction Immersed Boundary Method (ADR-IBM) (Giannenas and Laizet in Appl Math Model 99:606–627, 2021) can be used for Fluid–Structure Interaction (FSI) problems and can be combined with an Actuator Line Model (ALM) and a Computer-Aided Design (CAD) interface for high-fidelity simulations of fluid flow problems with rotors and geometrically complex immersed objects. The method relies on 1D cubic spline interpolations to reconstruct an artificial flow field inside the immersed object while imposing the appropriate boundary conditions on the boundaries of the object. The new capabilities of the method are demonstrated with the following flow configurations: a turbulent channel flow with the wall modelled as an immersed boundary, Vortex Induced Vibrations (VIVs) of one-degree-of-freedom (2D) and two-degree-of-freedom (3D) cylinders, a helicopter rotor and a multi-rotor unmanned aerial vehicle in hover and forward motion. These simulations are performed with the high-order fluid flow solver which is based on a 2D domain decomposition in order to exploit modern CPU-based supercomputers. It is shown that the ADR-IBM can be used for the study of FSI problems and for high-fidelity simulations of incompressible turbulent flows around moving complex objects with rotors.
Long-term culture of feline oviduct epithelial cells on permeable filter supports
Authors: Eder Susanne , Müller Karin , Chen Shuai , Schoen Jennifer
Published: September 2022

Basic knowledge about cellular and molecular mechanisms underlying feline reproduction is required to improve reproductive biotechnologies in endangered felids. Commonly, the domestic cat (Felis catus) is used as a model species, but many of the fine-tuned, dynamic reproductive processes can hardly be observed in vivo. This necessitates the development of in vitro models. The oviduct is a central reproductive organ hosting fertilization in the ampulla and early embryonic development in the isthmus part, which also functions as a sperm reservoir before fertilization. In other species, culturing oviduct epithelial cells in compartmentalized culture systems has proven useful to maintain oviduct epithelium polarization and functionality. Therefore, we made the first attempt to establish a compartmentalized long-term culture system of feline oviduct epithelial cells from both ampulla and isthmus. Cells were isolated from tissue samples (n = 33 animals) after routine gonadectomy, seeded on permeable filter supports and cultured at the liquid–liquid or air–liquid interface. Cultures were harvested after 21 days and microscopically evaluated for epithelial differentiation (monolayer formation with basal–apical polarization) and protein expression of marker genes (oviduct-specific glycoprotein, acetylated tubulin). Due to the heterogeneous and undefined native tissue material available for this study, the applied cell culture approach was only successful in a limited number of cases (five differentiated cultures). Even though the protocol needs optimization, our study showed that the compartmentalized culture approach is suitable for maintaining differentiated epithelial cells from both isthmus and ampulla of the feline oviduct.
Bayesian multi-species N-mixture models for unmarked animal communities
Authors: Mimnagh Niamh , Parnell Andrew , Prado Estevão , Moral Rafael de Andrade
Published: September 2022

We propose an extension of the N-mixture model that enables the estimation of abundances of multiple species as well as the correlations between them. Our novel multi-species N-mixture model (MNM) is the first to address the estimation of both positive and negative inter-species correlations, which allows us to assess the influence of the abundance of one species on another. We provide extensions that permit the analysis of data with excess of zero counts, and relax the assumption that populations are closed through the incorporation of an autoregressive term in the abundance. Our approach provides a method of quantifying the strength of association between species’ population sizes and is of practical use to population and conservation ecologists. We evaluate the performance of the proposed models through simulation experiments in order to examine the accuracy of both model estimates and coverage rates. The results show that the MNM models produce accurate estimates of abundance, inter-species correlations and detection probabilities at a range of sample sizes. The MNM models are applied to avian point data collected as part of the North American Breeding Bird Survey between 2010 and 2019. The results reveal an increase in Bald Eagle abundance in south-eastern Alaska in the decade examined.
Activation of sweet pepper defense responses by novel and known biocontrol agents of the genus Bacillus against Botrytis cinerea and Verticillium dahliae
Authors: Poveda Jorge , Calvo Javier , Barquero Marcia , González-Andrés Fernando
Published: September 2022

The Fresno-Benavente Pepper (F-BP) Protected Geographical Indication (PGI) is a horticultural crop characterized by its great agronomic, economic and cultural importance in the region of Castilla y León (Spain). Field production is threatened by verticillium wilt caused by Verticillium dahliae and postharvest losses due to grey mould caused by Botrytis cinerea. Eight Bacillus spp. strains endophytically isolated from F-BP roots were used in the study. By conducting an in vitro antagonism study, we found that all Bacillus strains were effective against B. cinerea and five of them showed high antagonism against V. dahliae, with B. siamensis and B. proteolyticus strains being the most effective against both pathogens. Eight Bacillus strains were used for an infection test in F-BP fruits and plants to test their activity against both fungal pathogens. We report that Bacillus thuringiensis, B. siamensis and B. pumilus (SCFC 1–2) could control B. cinerea in pepper fruits through direct action and local activation of plant defences. In the case of V. dahliae root infection, plant roots inoculated with B. siamensis and B. proteolyticus were able to significantly decrease the occurrence of disease through direct action and local activation of jasmonic acid as a defence response. Therefore, we propose that B. siamensis could be used to control B. cinerea and V. dahliae in F-BP fruits and plants, respectively, through direct antagonism as well as the induction of local plant defence responses.
Bayesian rule in the framework of uncertainty theory
Authors: Lio Waichon , Kang Rui
Published: September 2022

In Bayesian rule an unknown parameter is thought to be a quantity whose variation can be characterized by a prior distribution. Then some data are observed from a population whose distribution function is indexed by the unknown parameter and then the prior distribution is updated according to the observed data. The updated prior distribution is named as the posterior distribution. Based on uncertainty theory, this paper first makes a connection between posterior uncertainty distribution and likelihood function, and proposes a new method to obtain the posterior uncertainty distribution from the prior uncertainty distribution with given observed data. Some examples with special uncertainty distributions are employed to explain the calculation. Furthermore, an uncertain urn problem is provided to illustrate the application of the new method.
Is Gravitational Entanglement Evidence for the Quantization of Spacetime?
Authors: Döner M. Kemal , Großardt André
Published: September 2022

Experiments witnessing the entanglement between two particles interacting only via the gravitational field have been proposed as a test whether gravity must be quantized. In the language of quantum information, a non-quantum gravitational force would be modeled by local operations with classical communication (LOCC), which cannot generate entanglement in an initially unentangled state. This idea is criticized as too constraining on possible alternatives to quantum gravity. We present a parametrized model for the gravitational interaction of quantum matter on a classical spacetime, inspired by the de Broglie–Bohm formulation of quantum mechanics, which results in entanglement and thereby provides an explicit counterexample to the claim that only a quantized gravitational field possesses this capability.
Penrose junction conditions with $$\Lambda $$: geometric insights into low-regularity metrics for impulsive gravitational waves
Authors: Podolský Jiří , Steinbauer Roland
Published: September 2022

Impulsive gravitational waves in Minkowski space were introduced by Roger Penrose at the end of the 1960s, and have been widely studied over the decades. Here we focus on nonexpanding waves which later have been generalized to impulses traveling in all constant-curvature backgrounds, i.e., the (anti-)de Sitter universe. While Penrose’s original construction was based on his vivid geometric “scissors-and-paste” approach in a flat background, until recently a comparably powerful visualization and understanding has been missing in the case with a cosmological constant $${\Lambda \not =0}$$

Λ
≠
0

. Here we review the original Penrose construction and its generalization to non-vanishing $$\Lambda $$
Λ
in a pedagogical way, as well as the recently established visualization: A special family of global null geodesics defines an appropriate comoving coordinate system that allows to relate the distributional to the continuous form of the metric.
Escin suppresses immune cell infiltration and selectively modulates Nrf2/HO-1, TNF-α/JNK, and IL-22/STAT3 signaling pathways in concanavalin A-induced autoimmune hepatitis in mice
Authors: Elshal Mahmoud , Hazem Sara H.
Published: September 2022

The current study aims to investigate the possible protective effect of escin, the active constituent of a natural mixture of triterpene saponin glycoside, against immune-mediated hepatitis driven by concanavalin A (Con A) and to elucidate its possible underlying mechanisms. Adult male mice were administered Con A (15 mg/kg, intravenously) for 8 h. In the treated groups, mice were pretreated with escin daily (10 mg/kg in CMC, orally) for 4 days before Con A intoxication. In addition, escin was administered in a group to examine its effect on normal mice. Our results showed that escin inhibited Con A-induced elevation in liver enzymes (ALT, AST, and LDH) and curbed the Con A-induced hepatocyte necrosis and apoptosis together with abrogating the death pathway, JNK. Coincidentally, escin has shown a reduction in neutrophil, CD4+ T cell, and monocyte infiltration into the liver. In addition, escin modulated the cellular oxidant status by compensating for the Con A-depleted expression of the transcription factor Nrf2 and the stress protein hemeoxygenase-1. These effects were in good agreement with the restraining effect of escin on Con A-instigated overexpression of NF-κB and the pro-inflammatory cytokines TNF-α and IL-17A. Interestingly, Con A provoked the cellular protective pathway IL-22/STAT3, which was revoked by the escin pretreatment. In conclusion, escin shows extended antioxidant, anti-inflammatory, antinecrotic, and anti-apoptotic effects against Con A-induced immune-mediated hepatitis. These effects may collectively be via suppressing immune cell infiltration into the liver and selective modulation of Nrf2/HO-1, TNF-α/NF-κB, TNF-α/JNK, and IL-22/STAT3 signaling pathways.
pH-responsive cinnamaldehyde-TiO2 nanotube coating: fabrication and functions in a simulated diabetes condition
Authors: Lee Yichen , Huang Jingyan , Bing Zhaoxia , Yuan Kaiting , Yang Jinghong , Cai Min , Zhou Shiqi , Yang Bo , Teng Wei , Li Weichang , Wang Yan
Published: September 2022

Current evidence has suggested that diabetes increases the risk of implanting failure, and therefore, appropriate surface modification of dental implants in patients with diabetes is crucial. TiO2 nanotube (TNT) has an osteogenic nanotopography, and its osteogenic properties can be further improved by loading appropriate drugs. Cinnamaldehyde (CIN) has been proven to have osteogenic, anti-inflammatory, and anti-bacterial effects. We fabricated a pH-responsive cinnamaldehyde-TiO2 nanotube coating (TNT-CIN) and hypothesized that this coating will exert osteogenic, anti-inflammatory, and anti-bacterial functions in a simulated diabetes condition. TNT-CIN was constructed by anodic oxidation, hydroxylation, silylation, and Schiff base reaction to bind CIN, and its surface characteristics were determined. Conditions of diabetes and diabetes with a concurrent infection were simulated using 22-mM glucose without and with 1-μg/mL lipopolysaccharide, respectively. The viability and osteogenic differentiation of bone marrow mesenchymal stem cells, polarization and secretion of macrophages, and resistance to Porphyromonas gingivalis and Streptococcus mutans were evaluated. CIN was bound to the TNT surface successfully and released better in low pH condition. TNT-CIN showed better osteogenic and anti-inflammatory effects and superior bacterial resistance than TNT in a simulated diabetes condition. These findings indicated that TNT-CIN is a promising, multifunctional surface coating for patients with diabetes needing dental implants.
Conditions for the stability of ideal efficient solutions in parametric vector optimization via set-valued inclusions
Authors: Uderzo Amos
Published: September 2022

In present paper, an analysis of the stability behaviour of ideal efficient solutions to parametric vector optimization problems is conducted. A sufficient condition for the existence of ideal efficient solutions to locally perturbed problems and their nearness to a given reference value is provided by refining recent results on the stability theory of parameterized set-valued inclusions. More precisely, the Lipschitz lower semicontinuity property of the solution mapping is established, with an estimate of the related modulus. A notable consequence of this fact is the calmness behaviour of the ideal value mapping associated to the parametric class of vector optimization problems. Within such an analysis, a refinement of a recent existence result, specific for ideal efficient solutions to unperturbed problem and enhanced by related error bounds, is discussed. Some connections with the concept of robustness in multi-objective optimization are also sketched.
Accurate Calibration of Nuclear Recoils at the 100 eV Scale Using Neutron Capture
Authors: Wagner V. ,   on behalf of the CRAB Collaboration
Published: September 2022

Searches for light dark matter (DM) and studies of coherent elastic neutrino-nucleus scattering (CEvNS) imply the detection of nuclear recoils in the 100 eV range. However, an absolute energy calibration in this regime is still missing. The CRAB project proposes a method based on nuclear recoils induced by the emission of an MeV gamma following thermal neutron capture. A detailed feasibility study has shown that this method yields distinct nuclear recoil calibration peaks at 112 eV and 160 eV above background for tungsten. In the first phase, the CRAB project foresees to perform a nuclear recoil calibration of cryogenic CaWO4 detectors read-out by TES, similar to the detectors used in CRESST and NUCLEUS. The low-power TRIGA reactor in Vienna provides a clean beam of thermal neutrons well suited for such a measurement. Newly developed and compact sub-keV calibration sources based on x-ray fluorescence (XRF) provide an absolute energy calibration during operation at the research reactor as well as in the DM/CEvNS experiments. In the second phase, additional tagging of the photons produced in the de-excitation process will allow extending the calibration method to even lower energies and to a wider range of detector materials, such as Ge. Combined with the XRF source, CRAB may allow measuring energy quenching in the sub-keV regime.
Operation of an Archaeological Lead PbWO$$_4$$ Crystal to Search for Neutrinos from Astrophysical Sources with a Transition Edge Sensor
Authors: Ferreiro Iachellini N. , Pattavina L. , Abdelhameed A. H. , Bento A. , Canonica L. , Danevich F. , Dubovik O. M. , Fuchs D. , Garai A. , Mancuso M. , Petricca F. , Tupitsyna I. A.
Published: September 2022

The experimental detection of the CE$$\nu$$
ν
NS allows the investigation of neutrinos and neutrino sources with all-flavor sensitivity. Given its large content in neutrons and stability, Pb is a very appealing choice as target element. The presence of the radioisotope $$^{210}$$

210

Pb (T$$_{1/2}\sim$$

1
/
2

∼

22 yrs) makes natural Pb unsuitable for low-background, low-energy event searches. This limitation can be overcome employing Pb of archaeological origin, where several half-lives of $$^{210}$$

210

Pb have gone by. We present results of a cryogenic measurement of a 15 g PbWO$$_4$$

4

crystal, grown with archaeological Pb (older than $$\sim$$
∼
2000 yrs) that achieved a sub-keV nuclear recoil detection threshold. A ton-scale experiment employing such material, with a detection threshold for nuclear recoils of just 1 keV would probe the entire Milky Way for SuperNovae, with equal sensitivity for all neutrino flavors, allowing the study of the core of such exceptional events.
Design of the SPT-SLIM Focal Plane: A Spectroscopic Imaging Array for the South Pole Telescope
Authors: Barry P. S. , Anderson A. , Benson B. , Carlstrom J. E. , Cecil T. , Chang C. , Dobbs M. , Hollister M. , Karkare K. S. , Keating G. K. , Marrone D. , McMahon J. , Montgomery J. , Pan Z. , Robson G. , Rouble M. , Shirokoff E. , Smecher G.
Published: September 2022

The Summertime Line Intensity Mapper (SLIM) is a mm-wave line-intensity mapping (mm-LIM) experiment for the South Pole Telescope (SPT). The goal of SPT-SLIM is to serve as a technical and scientific pathfinder for the demonstration of the suitability and in-field performance of multi-pixel superconducting filterbank spectrometers for future mm-LIM experiments. Scheduled to deploy in the 2023-24 austral summer, the SPT-SLIM focal plane will include 18 dual-polarisation pixels, each coupled to an $$R = \lambda / \Delta \lambda = 300$$

R
=
λ
/
Δ
λ
=
300

thin-film microstrip filterbank spectrometer that spans the 2 mm atmospheric window (120–180 GHz). Each individual spectral channel feeds a microstrip-coupled lumped-element kinetic inductance detector, which provides the highly multiplexed readout for the 10k detectors needed for SPT-SLIM. Here, we present an overview of the preliminary design of key aspects of the SPT-SLIM focal plane array, a description of the detector architecture and predicted performance, and initial test results that will be used to inform the final design of the SPT-SLIM spectrometer array.
Teachers Can Make a Difference in Bullying: Effects of Teacher Interventions on Students’ Adoption of Bully, Victim, Bully-Victim or Defender Roles across Time
Authors: Burger Christoph , Strohmeier Dagmar , Kollerová Lenka
Published: September 2022

School bullying is a serious problem worldwide, but little is known about how teacher interventions influence the adoption of bullying-related student roles. This study surveyed 750 early adolescents (50.5% female; average age: 12.9 years, SD = 0.4) from 39 classrooms in two waves, six months apart. Peer ratings of classmates were used to categorize students to five different bullying-related roles (criterion: >1 SD): bully, victim, bully-victim, defender, and non-participant. Student ratings of teachers were used to obtain class-level measures of teacher interventions: non-intervention, disciplinary sanctions, group discussion, and mediation/victim support. Controlling for student- and class-level background variables, two multilevel multinomial logistic regression analyses were computed to predict students’ bullying-related roles at wave 2. In the static model, predictors were teacher interventions at wave 1, and in the dynamic model, predictors were teacher intervention changes across time. The static model showed that disciplinary sanctions reduced the likelihood of being a bully or victim, and group discussion raised the likelihood of being a defender. Mediation/victim support raised the likelihood of being a bully. The dynamic model complemented these results by indicating that increases in group discussion across time raised the likelihood of being a defender, whereas increases in non-intervention across time raised the likelihood of being a victim and reduced the likelihood of being a defender. These results show that teacher interventions have distinct effects on students’ adoption of bullying-related roles and could help to better target intervention strategies. The findings carry practical implications for the professional training of prospective and current teachers.
Inducing and blocking the goal to belong in an experimental setting: goal disengagement research using Cyberball
Authors: Rühs Farina , Greve Werner , Kappes Cathleen
Published: September 2022

In the present research, the Cyberball ostracism paradigm was adapted for experimental goal disengagement (GD) research: the goal to belong to a particular group is first induced in participants (via social interaction) and then blocked (via social exclusion) to trigger GD processes. In an online group setting, we experimentally tested the procedure’s suitability to investigate goal disengagement processes. A pilot study demonstrated successful induction of the goal to belong. In the main study (N = 180), exclusion from the group reduced participants’ perceived goal attainability (indicating goal blockage) and desirability (indicating goal disengagement) and their well-being. Regarding the regulatory functions of GD, results were mixed. During work on individual tasks, goal desirability decreased further and well-being was largely restored. However, GD changes were correlated only with changes in negative affect (and not other well-being measures). Findings suggest the procedure’s suitability for studying GD experimentally and employing it to investigate other measures of GD processes and their functionality in more detail.
Relapse patterns and radiation dose exposure in IDH wild-type glioblastoma at first radiographic recurrence following chemoradiation
Authors: Shidoh Satoka , Savjani Ricky R. , Cho Nicholas S. , Ullman Henrik E. , Hagiwara Akifumi , Raymond Catalina , Lai Albert , Nghiemphu Phionah L. , Liau Linda M. , Pope Whitney B. , Cloughesy Timothy F. , Kaprealian Tania B. , Salamon Noriko , Ellingson Benjamin M.
Published: September 2022

Purpose

To quantify the radiation dose distribution and lesion morphometry (shape) at baseline, prior to chemoradiation, and at the time of radiographic recurrence in patients with glioblastoma (GBM).

Methods

The IMRT dose distribution, location of the center of mass, sphericity, and solidity of the contrast enhancing tumor at baseline and the time of tumor recurrence was quantified in 48 IDH wild-type GBM who underwent postoperative IMRT (2 Gy daily for total of 60 Gy) with concomitant and adjuvant temozolomide.

Results

Average radiation dose within enhancing tumor at baseline and recurrence was ≥ 60 Gy. Centroid location of the enhancing tumor shifted an average of 11.3 mm at the time of recurrence with respect to pre-IMRT location. A positive correlation was observed between change in centroid location and PFS in MGMT methylated patients (P = 0.0007) and Cox multivariate regression confirmed centroid distance from baseline was associated with PFS when accounting for clinical factors (P = 0.0189). Lesion solidity was higher at recurrence compared to baseline (P = 0.0118). Tumors that progressed > 12 weeks after IMRT were significantly more spherical (P = 0.0094).

Conclusion

Most GBMs recur local within therapeutic IMRT doses; however, tumors with longer PFS occurred further from the original tumor location and were more solid and/or nodular.
Orthogonal Cauchy-like matrices
Authors: Fasino Dario
Published: September 2022

Cauchy-like matrices arise often as building blocks in decomposition formulas and fast algorithms for various displacement-structured matrices. A complete characterization for orthogonal Cauchy-like matrices is given here. In particular, we show that orthogonal Cauchy-like matrices correspond to eigenvector matrices of certain symmetric matrices related to the solution of secular equations. Moreover, the construction of orthogonal Cauchy-like matrices is related to that of orthogonal rational functions with variable poles.
Nasal Irrigation Delivery in Three Post-FESS Models From a Squeeze-bottle Using CFD
Authors: Salati Hana , Singh Narinder , Khamooshi Mehrdad , Vahaji Sara , Fletcher David F. , Inthavong Kiao
Published: September 2022

Purpose

Nasal saline irrigation is highly recommended in patients following functional endoscopic sinus surgery (FESS) to aid the postoperative recovery. Post-FESS patients have significantly altered anatomy leading to markedly different flow dynamics from those found in pre-op or non-diseased airways, resulting in unknown flow dynamics.

Methods

This work investigated how the liquid stream disperses through altered nasal cavities following surgery using Computational Fluid Dynamics (CFD). A realistic squeeze profile was determined from physical experiments with a 27-year-old male using a squeeze bottle with load sensors. The administration technique involved a head tilt of 45-degrees forward to represent a head position over a sink. After the irrigation event that lasted 4.5 s, the simulation continued for an additional 1.5 s, with the head orientation returning to an upright position.

Results

The results demonstrated that a large maxillary sinus ostium on the right side allows saline penetration into this sinus. The increased volume of saline entering the maxillary sinus limits the saline volume available to the rest of the sinonasal cavity and reduces the surface coverage of the other paranasal sinuses. The average wall shear stress was higher on the right side than on the other side for two patients. The results also revealed that head position alters the sinuses’ saline residual, especially the frontal sinuses.

Conclusion

While greater access to sinuses is achieved through FESS surgery, patients without a nasal septum limits posterior sinus penetration due to the liquid crossing over to the contralateral cavity and exiting the nasal cavity early.
What Libertarians (Should) Think About Inheritance Taxation
Authors: Twele Marcel
Published: September 2022

Recently, there has been an effort to make libertarianism compatible with a redistributive inheritance tax: When the tax is levied, the taxpayer in question is already dead and as such she cannot be a bearer of rights. The state is therefore allowed to redistribute the (value of) the estate according to some distributive principle. I consider (and finally dismiss) four successive arguments, each concluding that the state is allowed to use the estate for redistributive purposes. I show that neither of them is able to reconcile (right-) libertarianism with a redistributive inheritance tax. Instead of trying to square the circle, proponents of such a tax should meet the theoretical essentials of (right-) libertarianism head-on.
Progression in Self-Efficacy, Interest, Identity, Sense of Belonging, Perceived Recognition and Effectiveness of Peer Interaction of Physics Majors and Comparison with Non-Majors and Ph.D. Students
Authors: Whitcomb Kyle M. , Maries Alexandru , Singh Chandralekha
Published: September 2022

The importance of science beliefs such as self-efficacy, interest, identity, sense of belonging, perceived recognition and effectiveness of peer interaction in science education has been increasingly recognized in recent years. Self-efficacy, interest, and identity can be considered students’ internal beliefs, and sense of belonging, perceived recognition and effectiveness of peer interaction relate to students’ perception of the inclusiveness of the instructional environment. Prior studies in physics education regarding these beliefs have focused primarily on introductory physics courses. Here, we use five years of data from a validated survey administered to non-majors (in courses with physics majors) during their first year, physics majors throughout their undergraduate education, and first-year physics Ph.D. students at a large research university in the United States. We find that physics majors in the first year responded to the survey prompts more positively than their non-physics major peers who were in the same introductory courses, with the largest differences in perceived recognition, interest, and physics identity and somewhat smaller differences in self-efficacy, perception of peer interaction, and sense of belonging. Further, the average survey responses of physics majors for each belief remain largely constant over time from their first year of the undergraduate curriculum through the last year and comparable to the Ph.D. students. This suggests that students are adjusting their interpretation of the survey items to match the current level of expertise expected of them in the course in which the survey was administered. One exception occurs in the second year, when peer interaction and sense of belonging reach a minimum. This may be the case because the second year is a particularly difficult time for students as they adjust to classes consisting primarily of physics majors. Moreover, physics identity dips to the lowest value in the fourth year when many students are contemplating continuing in physics beyond their undergraduate years or switching fields. We also find that, consistent with prior studies with introductory students, perceived recognition is the best predictor of physics identity for physics majors throughout their entire physics education, pointing to the importance of instructors making a concerted effort to recognize and affirm their students throughout their education.