bluuebunny/crossref_metadata_2025 huggingface dataset:
Yearly Energy Performance Assessment of Employing Expanded Polystyrene with Variable Temperature and Moisture–Thermal Conductivity Relationship
Authors: Khoukhi Maatouk , Abdelbaqi Shaimaa , Hassan Ahmed
Published: September 2019

This paper investigated the impact of the changes of thermal conductivity of an expanded polystyrene insulation layer embedded in a typical residential building on the cooling effect at different temperatures and moisture contents. The simulation was performed using expanded polystyrene (EPS) in the extremely hot conditions of Al-Ain (United Arab Emirates, UAE) at different levels of density, denoted as low density LD (12 kg/m3), high density HD (20 kg/m3), ultra-high density UHD (30 kg/m3), and super-high density SHD (35 kg/m3), and three moisture content levels (10%, 20%, and 30%), compared to dry LD insulation material. The thermal performance of the building incorporating polystyrene with variable thermal conductivity (λ-value) was compared to one with a constant thermal conductivity by assessing the additional cooling demand and capacity due to the λ-relationship with time, using e-quest as a building energy analysis tool. The results showed that, when the λ-value was modeled as a function of operating temperature, its effect on the temperature profile during daytime was significant compared with the use of a constant λ-value. The monthly energy consumption for cooling required by the building was found to be higher in the case of variable thermal conductivity for the LD sample. The yearly average change in space cooling demand and cooling capacity when employing polystyrenes with constant and variable thermal conductivity increased with the increase of the moisture content. Indeed, the highest changes in cooling demand and capacity were 6.5% and 8.8% with 30% moisture content polystyrene.
Modal Analysis of Bolted Structure Based on Equivalent Material of Joint Interface
Authors: Zhang Kai , Li Guoxi , Gong Jingzhong , Wan Fei
Published: September 2019

Modal performance of a bolted structure is important when considering a precise mechanical product. Joint interface is a critical aspect of a bolted structure, which is difficult to analyze because of its rough profiles. Equivalent material (EM) is used to simplify the joint interface, which reduces the computational cost and modeling difficulty. Using a modified fractal model based on an oblique asperity contact, we calculated the elastic modulus, the shear modulus, the Poisson’s ratio, and the density of EM. The finite element method was applied to discriminate between the resonant frequencies of bolted structures with EM and without EM. The simulation results are compared with the classical frequency response experiment. The errors between experiments and the bolted structures with EM are less than 10%, which are much less than those without EM. It can be concluded that bolted structures with EM are more reliable and reasonable. Furthermore, the effect of EM is more obvious when the joint interface has a small size, roughness, and tightening torque.
Effects of Compaction Velocity on the Sinterability of Al-Fe-Cr-Ti PM Alloy
Authors: Yuan Xianjie , Qu Xuanhui , Yin Haiqing , Yan Zhenwei , Tan Zhaojun
Published: September 2019

In this research, the effects of the compaction velocity on the sinterability of the Al–Fe–Cr–Ti powder metallurgy (PM) alloy by high velocity compaction were investigated. The Al–Fe–Cr–Ti alloy powder was compacted with different velocities by high velocity compaction and then sintered under a flow of high pure (99.999 wt%) nitrogen gas. Results indicated that both the sintered density and mechanical properties increased with increasing compaction velocity. By increasing the compaction velocity, the shrinkage of the sintered samples decreased. A maximum sintered density of 2.85 gcm−3 (relative density is 98%) was obtained when the compaction velocity was 9.4 ms−1. The radial and axial shrinkage were controlled to less than 1% at a compaction velocity of 9.4 ms−1. At a compaction velocity of 9.4 ms−1, sintered compacts with an ultimate tensile strength of 222 MPa and a yield strength of 160 MPa were achieved. The maximum elongation was observed to be 2.6%. The enhanced tensile properties of the Al–Fe–Cr–Ti alloy were mainly due to particle boundary strengthening.
Update on Monoterpenes from Red Macroalgae: Isolation, Analysis, and Bioactivity
Authors: Cikoš Ana-Marija , Jurin Mladenka , Čož-Rakovac Rozelindra , Jokić Stela , Jerković Igor
Published: September 2019

Macroalgae produce a wide range of monoterpenes as secondary metabolites of mevalonate (MVA) and/or methylerythritol phosphate (MEP) pathway (often including haloperoxidase action). Great biodiversity of macroalgal monoterpenes was reported including acyclic, monocyclic, and bicyclic structures. Halogenated monoterpenes exhibited significant biological activity (e.g., anticancer, antiplasmodial, and insecticidal) that is influenced by the number of present halogens (higher halogen content is preferable, especially bromine) and their position within the monoterpene skeleton. In distinction from the existing reviews, the present review provides novelty with respect to: (a) exclusively monoterpenes from red macroalgae are targeted; (b) biosynthesis, isolation, and analysis, as well as bioactivity of monoterpenes are represented; (c) the methods of their isolation, analysis, and structure elucidation are summarized; (d) the bioactivity of macroalgal monoterpenes is systematically presented with emphasis on anticancer activity; (e) the literature references were updated.
Neutral Lipid Content in Lipid Droplets: Potential Biomarker of Cordycepin Accumulation in Cordycepin-Producing Fungi
Authors: Qin Peng , Wang ZhiYe , Lu DengXue , Kang HongMei , Li Guang , Guo Rui , Zhao YuHui , Han RongBing , Ji Bing , Zeng Yang
Published: September 2019

To clarify the relationship between neutral lipid content and cordycepin accumulation in Cordyceps militaris, mutants were generated from mixed spores of two C. militaris strains with varying cordycepin-producing capacities. Fifteen stable mutants producing from 0.001 to 2.363 mg/mL cordycepin were finally selected. The relative fluorescence intensities of the 15 mutants, two C. militaris strains and an Aspergillus nidulans strain at different concentrations of lyophilized mycelium powder were then investigated using the Nile red method. The mutant CM1-1-1 with the highest relative fluorescence intensity among the eighteen strains was selected for optimizing the Nile red method. Relative fluorescence intensity was linearly correlated with cordycepin concentration in liquid broth (R2 = 0.9514) and in lyophilized mycelium powder (R2 = 0.9378) for the 18 cordycepin-producing strains under identical culture conditions and with cordycepin concentration in liquid broth (R2 = 0.9727) and in lyophilized mycelium powder (R2 = 0.9613) for CM1-1-1 under eight different sets of conditions. In addition, the cordycepin content in lyophilized mycelium powder measured by the Nile red method was linearly correlated with that determined by an HPLC method (R2 = 0.9627). In conclusion, neutral lipids in lipid droplets are required during cordycepin accumulation; these neutral lipids are potential biomarkers of cordycepin biosynthesis.
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway
Authors: Jing Liang , Jiang Jing-Ru , Liu Dong-Mei , Sheng Ji-Wen , Zhang Wei-Fen , Li Zhi-Jian , Wei Liu-Ya
Published: September 2019

The purpose of this study was to characterize the polysaccharides from Athyrium multidentatum (Doll.) Ching (AMC) rhizome and explore the protective mechanism against d-galactose-induced oxidative stress in aging mice. Methods: A series of experiments, including molecular weight, monosaccharide composition, Fourier transform infrared (FT-IR) spectroscopy, and 1H nuclear magnetic resonance (1H NMR) spectroscopy were carried out to characterize AMC polysaccharides. The mechanism was investigated exploring d-galactose-induced aging mouse model. Quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and western blotting assays were performed to assess the gene and protein expression in liver. Key findings: Our results showed that AMC polysaccharides were mainly composed of mannose (Man), rhamnose (Rha), glucuronic acid (Glc A), glucose (Glc), galactose (Gal), arabinose (Ara), and fucose (Fuc) in a molar ratio of 0.077:0.088:0.09:1:0.375:0.354:0.04 with a molecular weight of 33203 Da (Mw). AMC polysaccharides strikingly reversed d-galactose-induced changes in mice, including upregulated phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor-erythroid 2-related factor 2 (Nrf2), forkhead box O3a (FOXO3a), and hemeoxygenase-1 (HO-1) mRNA expression, raised Bcl-2/Bax ratio, downregulated caspase-3 mRNA expression, enhanced Akt, phosphorylation of Akt (p-Akt), Nrf2 and HO-1 protein expression, decreased caspase-3, and Bax protein expression. Conclusion: AMC polysaccharides attenuated d-galactose-induced oxidative stress and cell apoptosis by activating the PI3K/AKT pathway, which might in part contributed to their anti-aging activity.
Effect of Nanocrystallization of Anthocyanins Extracted from Two Types of Red-Fleshed Apple Varieties on Its Stability and Antioxidant Activity
Authors: Xu Jihua , Li Xinxin , Liu Shifeng , Zhao Peilei , Huo Heqiang , Zhang Yugang
Published: September 2019

Red-fleshed apple (Malus sieversii f. neidzwetzkyana (Dieck) Langenf) has attracted more and more attention due to its enriched anthocyanins and high antioxidant activity. In this study we extracted total anthocyanins and phenols from two types of red-fleshed apples—Xinjing No.4 (XJ4) and Red Laiyang (RL)—to study the stability and antioxidant activity of anthocyanins after encapsulation onto Corn Starch Nanoparticles (CSNPs). The results indicated the anthocyanins and total phenol levels of XJ4 were 2.96 and 2.25 times higher than those of RL respectively. The anthocyanin concentration and loading time had a significant effect on CSNPs encapsulation, and XJ4 anthocyanins always showed significantly higher loading capacity than RL. After encapsulation, the morphology of RL-CSNPs and XJ4-CSNPs was still spherical with a smooth surface as CSNPs, but the particle size increased compared to CSNPs especially for RL-CSNPs. Different stress treatments including UV light, pH, temperature, and salinity suggested that XJ4-CSNPs exhibited consistently higher stability than RL-CSNPs. A significantly enhanced free radical scavenging rate under stress conditions was observed, and XJ4-CSNPs had stronger antioxidant activity than RL-CSNPs. Furthermore, XJ4-CSNPs exhibited a slower released rate than RL-CSNPs in simulated gastric (pH 2.0) and intestinal (pH 7.0) environments. Our research suggests that nanocrystallization of anthocyanins is an effective method to keep the anthocyanin ingredients intact and active while maintaining a slow release rate. Compared to RL, encapsulation of XJ4 anthocyanins has more advantages, which might be caused by the significant differences in the metabolites of XJ4. These findings give an insight into understanding the role of nanocrystallization using CSNPs in enhancing the antioxidant ability of anthocyanins from different types of red-fleshed apples, and provide theoretical foundations for red-fleshed apple anthocyanin application.
Improving Interlaminar Fracture Toughness and Impact Performance of Carbon Fiber/Epoxy Laminated Composite by Using Thermoplastic Fibers
Authors: Chen Ling , Wu Li-Wei , Jiang Qian , Tian Da , Zhong Zhili , Wang Yan , Fu Hong-Jun
Published: September 2019

The effects of thermoplastic polyimide (PI) and polypropylene (PP) fibers and areal density of toughened layer on interlaminar fracture toughness and impact performance of carbon fiber/epoxy (CF/EP) laminated composites were studied. Mode I interlaminar fracture toughness (GIC) was analyzed via double cantilever beam (DCB) tests. When comparing for the toughener type, PI played a positive role in enhancing the mode-I fracture toughness, while PP was not effective due to the less fiber bridge formed during composite curing. The toughening effects of areal density of PI were further investigated by end notched flexure (ENF) testing and low velocity impact testing to better understand the toughening mechanisms. The results revealed that the toughening effect reached its best effectiveness when the areal density of toughened layer was 30 g/m2. Compared with the control group, GIC and GIIC of CF/EP laminated composite were increased by 98.49% and 84.07%, and Fmax and Ee were enhanced by 92.38% and 299.08% under low velocity impact. There is no obvious delamination phenomenon on the surface of laminates after low velocity impact, indicating the improved interlaminar and impact performance of laminated composite.
Bifunctional Bioactive Polymer Surfaces with Micrometer and Submicrometer-sized Structure: The Effects of Structure Spacing and Elastic Modulus on Bioactivity
Authors: Elsayed Sarah M. , Widyaya Vania Tanda , Shafi Yasir , Eickenscheidt Alice , Lienkamp Karen
Published: September 2019

This study presents a comparison of two types of bifunctional structured surface that were made from the same polymer –– an antimicrobial polycation (a synthetic mimic of an antimicrobial peptide, SMAMP) and a protein-repellent polyzwitterion (poly(sulfobetaines), PSB). The first type of bifunctional surface was fabricated by a colloidal lithography (CL) based process where the two polymers were immobilized sequentially onto pre-structured surfaces with a chemical contrast (gold on silicon). This enabled site-selective covalent attachment. The CL materials had a spacing ranging from 200 nm to 2 µm. The second type of structured surface (spacing: 1 – 8.5 µm) was fabricated using a microcontact printing (µCP) process where SMAMP patches were printed onto a PSB network, so that 3D surface features were obtained. The thus obtained materials were studied by quantitative nanomechanical measurements using atomic force microscopy (QNM-AFM). The different architectures led to different local elastic moduli at the polymer-air interface, where the CL surfaces were much stiffer (Derjaguin-Muller-Toporov (DMT) modulus = 20 ± 0.8 GPa) compared to the structured 3D networks obtained by µCP (DMT modulus = 42 ± 1.1 MPa). The effects of the surface topology and stiffness on the antimicrobial activity against Escherichia coli, the protein repellency (using fibrinogen), and the compatibility with human gingival mucosal keratinocytes were investigated. The softer 3D µCP surfaces had simultaneous antimicrobial activity, protein repellency, and cell compatibility at all spacings. For the stiffer CL surfaces, quantitative simultaneous antimicrobial activity and protein repellency was not obtained. However, the cell compatibility could be maintained at all spacings. The optimum spacing for the CL materials was in the range of 500 nm–1 µm, with significantly reduced antimicrobial activity at 2 µm spacing. Thus, the soft polymer network obtained by µCP could be more easily optimized than the stiff CL surface, and had a broader topology range of optimal or near-optimal bioactivity.
Screening 89 Pesticides in Fishery Drugs by Ultrahigh Performance Liquid Chromatography Tandem Quadrupole-Orbitrap Mass Spectrometer
Authors: Wang Shou-Ying , Kong Cong , Chen Qing-Ping , Yu Hui-Juan
Published: September 2019

Multiclass screening of drugs with high resolution mass spectrometry is of great interest due to its high time-efficiency and excellent accuracy. A high-scale, fast screening method for pesticides in fishery drugs was established based on ultrahigh performance liquid chromatography tandem quadrupole-Orbitrap high-resolution mass spectrometer. The target compounds - were diluted in methanol and extracted by ultrasonic treatment, and the extracts were diluted with MeOH-water (1:1, v/v) and centrifuged to remove impurities. The chromatographic separation was performed on an Accucore aQ-MS column (100 mm × 2.1 mm, 2.6 μm) with gradient elution using 0.1% formic acid in water (containing 5 mmol/L ammonium formate) and 0.1% formic acid in methanol (containing 5 mmol/L ammonium formate) in Full Scan/dd-MS2 (TopN) scan mode. A screening database, including mass spectrometric and chromatographic information, was established for identification of compounds. The screening detection limits of methods ranged between 1–500 mg/kg, the recoveries of real samples spiked with the concentration of 10 mg/kg and 100 mg/kg standard mixture ranged from 70% to 110% for more than sixty compounds, and the relative standard deviations (RSDs) were less than 20%. The application of this method showed that target pesticides were screened out in 10 samples out of 21 practical samples, in which the banned pesticide chlorpyrifos were detected in 3 out of the 10 samples.
Anti-Inflammatory Properties of Bellevalia saviczii Root Extract and Its Isolated Homoisoflavonoid (Dracol) Are Mediated by Modification on Calcium Signaling
Authors: Savio Monica , Ibrahim Mohammed Farhad , Scarlata Chiara , Orgiu Matteo , Accardo Giuseppe , Sardar Abdullah Shakur , Moccia Francesco , Stivala Lucia Anna , Brusotti Gloria
Published: September 2019

Bellevalia saviczii is a medicinal plant used as anti-rheumatic and anti-inflammatory herbal remedy in Iraqi-Kurdistan. The aim of this study was to evaluate the anti-inflammatory activity of its extract and the isolated homoisoflavonoid (Dracol) by studying the Ca2+-dependent NF-kB pathway. Nuclear translocation of p65 NF-kB subunit, as parameter of NF-kB activation, was visualized in human leukemic monocytes by immunofluorescence and Western blot analyses, after cell treatment with B. saviczii root extract or Dracol followed by Lipopolysaccharide stimulation. In parallel, Ca2+ signals responsible for NF-kB activation and levels of inflammatory cytokines were investigated. LPS-induced p65 translocation was evident in monocytes and both treatments, in particular that with Dracol, were able to counteract this activation. Intracellular Ca2+ oscillations were halted and the cytokine release reduced. These results confirm the traditional anti-inflammatory efficacy of B. saviczii and identify one of the molecules in the extract which appears to be responsible of this action.
Sensory Metabolite Profiling in a Date Pit Based Coffee Substitute and in Response to Roasting as Analyzed via Mass Spectrometry Based Metabolomics
Authors: Farag Mohamed A. , Otify Asmaa M. , El-Sayed Aly M. , Michel Camilia G. , ElShebiney Shaimaa A. , Ehrlich Anja , Wessjohann Ludger A.
Published: September 2019

Interest in developing coffee substitutes is on the rise, to minimizing its health side effects. In the Middle East, date palm (Phoenix dactylifera L.) pits are often used as a coffee substitute post roasting. In this study, commercially-roasted date pit products, along with unroasted and home-prepared roasted date pits, were subjected to analyses for their metabolite composition, and neuropharmacological evaluation in mice. Headspace SPME-GCMS and GCMS post silylation were employed for characterizing its volatile and non-volatile metabolite profile. For comparison to roasted coffee, coffee product was also included. There is evidence that some commercial date pit products appear to contain undeclared additives. SPME headspace analysis revealed the abundance of furans, pyrans, terpenoids and sulfur compounds in roasted date pits, whereas pyrroles and caffeine were absent. GCMS-post silylation employed for primary metabolite profiling revealed fatty acids’ enrichment in roasted pits versus sugars’ abundance in coffee. Biological investigations affirmed that date pit showed safer margin than coffee from its LD50, albeit it exhibits no CNS stimulant properties. This study provides the first insight into the roasting impact on the date pit through its metabolome and its neuropharmacological aspects to rationalize its use as a coffee substitute.
Electrical and Electrochemical Behavior of Carbon Paste Electrodes Modified with Ionic Liquids Based in N-Octylpyridinium Bis(Trifluoromethylsulfonyl)Imide. A Theoretical and Experimental Study
Authors: Báez Carla , Navarro Freddy , Fuenzalida Francesca , Aguirre María J. , Arévalo M. Carmen , Afonso María , García Camilo , Ramírez Galo , Palenzuela J. Antonio
Published: September 2019

In this work, we studied carbon paste electrodes (CPEs) with two kinds of binders: mineral oil or ionic liquids (IL) derived from N-substituted octyl pyridinium bis(trifluoromethylsulfonyl)imide with the substituents H-, CH3-, CN- and CF3-. The work aims to study this series of IL and determine a possible effect of the substituent of the cation in the behavior of the IL as a binder of graphite for obtaining IL-CPEs. The electrochemical response and the electrical behavior were measured by cyclic voltammetry and electrochemical impedance spectroscopy, respectively. Surprisingly, the substituent does not affect the cyclic voltammetry response because in all the cases, high resistance and high capacitive currents were obtained. The best response in terms of conductivity is obtained by CPE. In the case of impedance measurements, the substituent does not cause differences, and in all the cases, the IL-CPEs show nearly the same responses. CPE shows lower capacitance and higher resistance for diffusion compared to the IL-CPEs due to his lower porosity. The high resistance showed by the IL-CPEs by cyclic voltammetry can be attributed to poorly intermolecular forces among graphite, water, electrolyte, and ILs as demonstrated by theoretical calculations.
Strain-Mediated Bending of InP Nanowires through the Growth of an Asymmetric InAs Shell
Authors: Greenberg Ya’akov , Kelrich Alexander , Cohen Shimon , Kar-Narayan Sohini , Ritter Dan , Calahorra Yonatan
Published: September 2019

Controlling nanomaterial shape beyond its basic dimensionality is a concurrent challenge tackled by several growth and processing avenues. One of these is strain engineering of nanowires, implemented through the growth of asymmetrical heterostructures. Here, we report metal–organic molecular beam epitaxy of bent InP/InAs core/shell nanowires brought by precursor flow directionality in the growth chamber. We observe the increase of bending with decreased core diameter. We further analyze the composition of a single nanowire and show through supporting finite element simulations that strain accommodation following the lattice mismatch between InP and InAs dominates nanowire bending. The simulations show the interplay between material composition, shell thickness, and tapering in determining the bending. The simulation results are in good agreement with the experimental bending curvature, reproducing the radius of 4.3 µm (±10%), for the 2.3 µm long nanowire. The InP core of the bent heterostructure was found to be compressed at about 2%. This report provides evidence of shape control and strain engineering in nanostructures, specifically through the exchange of group-V materials in III–V nanowire growth.
Solution-Processed PEDOT:PSS/MoS2 Nanocomposites as Efficient Hole-Transporting Layers for Organic Solar Cells
Authors: Ramasamy Madeshwaran Sekkarapatti , Ryu Ka Yeon , Lim Ju Won , Bibi Asia , Kwon Hannah , Lee Ji-Eun , Kim Dong Ha , Kim Kyungkon
Published: September 2019

An efficient hole-transporting layer (HTL) based on functionalized two-dimensional (2D) MoS2-poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) composites has been developed for use in organic solar cells (OSCs). Few-layer, oleylamine-functionalized MoS2 (FMoS2) nanosheets were prepared via a simple and cost-effective solution-phase exfoliation method; then, they were blended into PEDOT:PSS, a conducting conjugated polymer, and the resulting hybrid film (PEDOT:PSS/FMoS2) was tested as an HTL for poly(3-hexylthiophene):[6,6]-phenyl-C61-butyric acid methyl ester (P3HT:PCBM) OSCs. The devices using this hybrid film HTL showed power conversion efficiencies up to 3.74%, which is 15.08% higher than that of the reference ones having PEDOT:PSS as HTL. Atomic force microscopy and contact angle measurements confirmed the compatibility of the PEDOT:PSS/FMoS2 surface for active layer deposition on it. The electrical impedance spectroscopy analysis revealed that their use minimized the charge-transfer resistance of the OSCs, consequently improving their performance compared with the reference cells. Thus, the proposed fabrication of such HTLs incorporating 2D nanomaterials could be further expanded as a universal protocol for various high-performance optoelectronic devices.
Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging
Authors: Sandra Febrina , Khaliq Nisar Ul , Sunna Anwar , Care Andrew
Published: September 2019

In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio–nano” interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.
The Effects of Dairy Intake on Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Sochol Kristen M. , Johns Tanya S. , Buttar Rupinder S. , Randhawa Lovepreet , Sanchez Edeline , Gal Maya , Lestrade Katherine , Merzkani Massini , Abramowitz Matthew K. , Mossavar-Rahmani Yasmin , Melamed Michal L.
Published: September 2019

The incidence of type 2 diabetes mellitus (DM) has increased in the US over the last several years. The consumption of low-fat dairy foods has been linked with decreasing the risk of DM but studies have yet to show a clear correlation. We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effects of dairy intake on homeostatic model assessment of insulin resistance (HOMA-IR), waist circumference, and body weight. In MEDLINE and Embase, we identified and reviewed 49 relevant RCTs: 30 had appropriate data format for inclusion in the meta-analysis. Using the Review Manager 5 software, we calculated the pooled standardized mean differences comparing dairy dietary interventions to control for our outcomes of interest. For HOMA-IR (794 individuals), we found a mean difference of −1.21 (95% CI −1.74 to −0.67; p-value < 0.00001; I2 = 92%). For waist circumference (1348 individuals), the mean difference was −1.09 cm (95% CI 1.68 to −0.58; p-value < 0.00001; I2 = 94%). For body weight (2362 individuals), the dairy intake intervention group weighed 0.42 kg less than control (p-value < 0.00001; I2 = 92%). Our findings suggest that dairy intake, especially low-fat dairy products, has a beneficial effect on HOMA-IR, waist circumference, and body weight. This could impact dietary recommendations to reduce DM risk.
Free Amino Acid Content in Human Milk Is Associated with Infant Gender and Weight Gain during the First Four Months of Lactation
Authors: Baldeón Manuel E. , Zertuche Federico , Flores Nancy , Fornasini Marco
Published: September 2019

Background: There is a growing interest regarding the physiological role of free amino acids (FAA) present in human milk (HM). Recent studies show FAA in HM could be influenced by infants’ gender and could have an important role in their growth and development. We studied the concentrations of FAA in HM and potential associations with infants’ gender and their patterns of growth in a cohort of Ecuadorian women. Methods: Human milk samples were collected after approximately eight hours of overnight fast within one week (colostrum), 2 weeks (transition milk), and 2 and/or 4 months (mature milk) after parturition. Free AA were determined by cation-exchange chromatography separation. Results: We observed significantly higher concentrations of Glu 14.40 (1.35, 27.44), Gly 1.82 (0.24, 3.4), Cys 0.36 (0.03, 0.68), and Tyr 0.24 (0.02, 0.46) in HM intended for boys. Free Glu, Gly, Cys, and Tyr concentrations increased with time of lactation. In addition, there were higher concentrations of Glu 28.62 (1.78, 55.46) and Ala 7.16 (1.26, 13.06) in HM for children that presented faster weight gain than for those with slower gain. Conclusions: The present results showed that there are differences in FAA levels in HM intended for male and fast-growing children.
Predictive Power of In Silico Approach to Evaluate Chemicals against M. tuberculosis: A Systematic Review
Authors: Timo Giulia Oliveira , Reis Rodrigo Souza Silva Valle dos , Melo Adriana Françozo de , Costa Thales Viana Labourdette , Magalhães Pérola de Oliveira , Homem-de-Mello Mauricio
Published: September 2019

Mycobacterium tuberculosis (Mtb) is an endemic bacterium worldwide that causes tuberculosis (TB) and involves long-term treatment that is not always effective. In this context, several studies are trying to develop and evaluate new substances active against Mtb. In silico techniques are often used to predict the effects on some known target. We used a systematic approach to find and evaluate manuscripts that applied an in silico technique to find antimycobacterial molecules and tried to prove its predictive potential by testing them in vitro or in vivo. After searching three different databases and applying exclusion criteria, we were able to retrieve 46 documents. We found that they all follow a similar screening procedure, but few studies exploited equal targets, exploring the interaction of multiple ligands to 29 distinct enzymes. The following in vitro/vivo analysis showed that, although the virtual assays were able to decrease the number of molecules tested, saving time and money, virtual screening procedures still need to develop the correlation to more favorable in vitro outcomes. We find that the in silico approach has a good predictive power for in vitro results, but call for more studies to evaluate its clinical predictive possibilities.
Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver
Authors: Greiser Julia , Weigand Wolfgang , Freesmeyer Martin
Published: September 2019

This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver. The main focus was on two established imaging modalities: magnetic resonance imaging (MRI) and nuclear medicine, the latter including scintigraphy and positron emission tomography (PET). The review provides an overview on approved pharmaceuticals like Gd-based CA and 99mTc-based radiometal complexes, and also on novel agents such as 68Ga-based PET tracers. Metal complexes are presented by their imaging modality, with subsections focusing on their structure and mode of action. Uptake mechanisms, metabolism, and specificity are presented, in context with advantages and limitations of the diagnostic application and taking into account the respective imaging technique.
Development and Characterization of Eudragit®-Based Electrospun Nanofibrous Mats and Their Formulation into Nanofiber Tablets for the Modified Release of Furosemide
Authors: Vlachou Marilena , Kikionis Stefanos , Siamidi Angeliki , Kyriakou Sotiria , Tsotinis Andrew , Ioannou Efstathia , Roussis Vassilios
Published: September 2019

Furosemide, a chloride channel blocker ordinarily used as a high-ceiling or loop diuretic, is practically insoluble in water and dilute acids. Due to its acidic nature, furosemide is mostly absorbed in the stomach and in the upper small intestine. Efforts have focused on the development of sustained release systems of furosemide in order to improve the effectiveness of the drug, which exhibits poor aqueous solubility and poor permeability. Recently, electrospun nanofibrous drug delivery systems have emerged as promising alternative solid-dosage forms due to their advantages of high porosity, high surface to volume ratio, and high drug-loading efficacy. Herein, a number of nanofibrous mats composed of different types of Eudragit® polymers in various concentrations and combinations loaded with furosemide were designed, successfully electrospun, and characterized using SEM, FTIR, DSC, and TGA analyses. The nanofibrous nonwovens were formulated in nanofiber tablets and the release profile of furosemide from them was evaluated at pH 1.2 and 6.8 and compared to that of physical mixture matrix tablets of analogous composition as well as to that of a commercial formulation. It was found that the release of furosemide was compatible with the gastroretentive and slower intestinal release requirements with a well-defined absorption window, while some nanofiber formulations could act as furosemide carriers in emergency situations where a relatively fast onset of its action is required, as in the case of critically ill post-traumatic patients.
Preparation of Phase Change Microcapsules with the Enhanced Photothermal Performance
Authors: Tahan Latibari Sara , Eversdijk Jacco , Cuypers Ruud , Drosou Vassiliki , Shahi Mina
Published: September 2019

The performance of solar-thermal conversion systems can be improved by incorporation of encapsulated phase change materials. In this study, for the first time, CrodathermTM 60 as a phase change material (PCM) was successfully encapsulated within polyurea as the shell supporting material. While preparing the slurry samples, graphite nanoplatelet (GNP) sheets were also incorporated to enhance the thermal and photothermal properties of the prepared materials. The morphology and chemical properties of these capsules were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectrum, respectively. The results show the spherical-like and core-shell structure of capsules with an average diameter size of 3.34 μm. No chemical interaction was observed between the core and the supporting materials. The thermal characteristics of the microencapsulated PCMs (MEPCMs), analyzed by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), indicate that the prepared samples with 0.1 weight percentage of GNP possess the latent heat of 95.5 J/g at the phase transition temperature of about 64 °C. Analyzing the rheological properties of the prepared slurry with 16 wt % of MEPCMs proves that the prepared material meet the requirements given by the heat transfer applications. The thermal storage capacity, good thermal stability, and improved photothermal performance of the prepared material make it a potential candidate for using in direct absorption solar thermal applications.
Crystal Transition Behavior and Thermal Properties of Thermal-Energy-Storage Copolymer Materials with an n-Behenyl Side-Chain
Authors: Mao Yuchen , Gong Jin , Zhu Meifang , Ito Hiroshi
Published: September 2019

In this paper, we synthesized MC(BeA-co-MMA) copolymer microcapsules through suspension polymerization. The pendent n-behenyl group of BeA is highly crystalline, and it acts as the side-chain in the structure of BeA-co-MMA copolymer. The highly crystalline n-behenyl side-chain provides BeA-co-MMA copolymer thermal-energy-storage capacity. In order to investigate the correlation between the thermal properties and crystal structure of the BeA-co-MMA copolymer, the effects of monomer ratio, temperature changing and the changing rate, as well as synthesis method were discussed. The monomer ratio influenced crystal transition behavior and thermal properties greatly. The DSC results proved that when the monomer ratio of BeA and MMA was 3:1, MC(BeA-co-MMA)3 showed the highest average phase change enthalpy ΔH (105.1 J·g–1). It indicated that the n-behenyl side-chain formed a relatively perfect crystal region, which ensured a high energy storage capacity of the copolymer. All the DSC and SAXS results proved that the amount of BeA had a strong effect on the thermal-energy-storage capacity of the copolymer and the long spacing of crystals, but barely on the crystal lamella. It was found that MMA units worked like defects in the n-behenyl side-chain crystal structure of the BeA-co-MMA copolymer. Therefore, a lower fraction of MMA, that is, a higher fraction of BeA, contributed to a higher crystallinity of the BeA-co-MMA copolymer, providing a better energy storage capacity and thermoregulation property. ST(BeA-co-MMA) copolymer sheets with the same ingredients as microcapsules were also prepared through light-induced polymerization aiming at clarifying the effect of the synthesis method. The results proved that the synthesis method mainly influenced the copolymer chemical component, but lightly on the crystal packing of the n-behenyl side-chain.
The Direct Speed Control of Pmsm Based on Terminal Sliding Mode and Finite Time Observer
Authors: Wang Yao , Yu HaiTao , Che Zhiyuan , Wang Yuchen , Liu Yulei
Published: September 2019

A non-singular terminal sliding mode control based on finite time observer is designed to achieve speed direct control for the permanent magnet synchronous motor (PMSM) drive system. Speed and current are regulated in one loop under the non-cascade structure, taking place of the cascade structure control method in the vector control of PMSM. Based on the second-order speed function of the PMSM, the disturbance and parameters uncertainties are estimated by the designed finite time observer (FTO), and compensate to the drive system. The estimated value of the finite time observer will converge to the actual disturbance value in a finite time. A second-order non-singular terminal sliding mode controller is proposed to realize the speed and current single-loop, which can track the reference speed and reference current in a finite time. Rigorous stability analysis is established. Comparative results verified that the proposed method has faster speed tracking performance and disturbance rejection property.
On Thermal Infrared Remote Sensing of Plastic Pollution in Natural Waters
Authors: Goddijn-Murphy Lonneke , Williamson Benjamin
Published: September 2019

Plastic pollution in the world’s natural waters is of growing concern and currently receiving significant attention. However, remote sensing of marine plastic litter is still in the developmental stage. Most progress has been made in spectral remote sensing using visible to short-wave infrared wavelengths where optical physics applies. Thermal infrared (TIR) sensing could potentially monitor plastic water pollution but has not been studied in detail. We applied radiative transfer theory to predict TIR sensitivity to changes in the surface fraction of water covered by plastic litter and found that the temperature difference between the water surface and the surroundings controls the TIR signal. Hence, we mapped this difference for various months and times of the day using global SST (sea surface temperature) and t2m (temperature at 2 m height) hourly estimates from the European Centre for Medium-Range Weather Forecasts (ECMWF), ERA5. The maps show how SST-t2m difference varied, altering the anticipated effectivity of TIR floating plastic litter remote sensing. We selected several locations of interest to predict the effectivity of TIR sensing of the plastic surface fraction. TIR remote sensing has promising potential and is expected to be more effective in areas with a high air–sea temperature difference.
K-Matrix: A Novel Change-Pattern Mining Method for SAR Image Time Series
Authors: Peng Dong , Pan Ting , Yang Wen , Li Heng-Chao
Published: September 2019

In this paper, we present a novel method for change-pattern mining in Synthetic Aperture Radar (SAR) image time series based on a distance matrix clustering algorithm, called K-Matrix. As it is different from the state-of-the-art methods, which analyze the SAR image time series based on the change detection matrix (CDM), here, we directly use the distance matrix to determine changed pixels and extract change patterns. The proposed scheme involves two steps: change detection in SAR image time series and change-pattern discovery. First, these distance matrices are constructed for each spatial position over the time series by a dissimilarity measurement. The changed pixels are detected by using a thresholding algorithm on the energy feature map of all distance matrices. Then, according to the change detection results in SAR image time series, the changed areas for pattern mining are determined. Finally, the proposed K-Matrix algorithm which clusters distance matrices by the matrix cross-correlation similarity is used to group all changed pixels into different change patterns. Experimental results on two datasets of TerraSAR-X image time series illustrate the effectiveness of the proposed method.
A Novel Fault Detection Method for Rolling Bearings Based on Non-Stationary Vibration Signature Analysis
Authors: Zhen Dong , Guo Junchao , Xu Yuandong , Zhang Hao , Gu Fengshou
Published: September 2019

To realize the accurate fault detection of rolling element bearings, a novel fault detection method based on non-stationary vibration signal analysis using weighted average ensemble empirical mode decomposition (WAEEMD) and modulation signal bispectrum (MSB) is proposed in this paper. Bispectrum is a third-order statistic, which can not only effectively suppress Gaussian noise, but also help identify phase coupling. However, it cannot effectively decompose the modulation components which are inherent in vibration signals. To alleviate this issue, MSB based on the modulation characteristics of the signals is developed for demodulation and noise reduction. Still, the direct application of MSB has some interfering frequency components when extracting fault features from non-stationary signals. Ensemble empirical mode decomposition (EEMD) is an advanced nonlinear and non-stationary signal processing approach that can decompose the signal into a list of stationary intrinsic mode functions (IMFs). The proposed method takes advantage of WAEEMD and MSB for bearing fault diagnosis based on vibration signature analysis. Firstly, the vibration signal is decomposed into IMFs with a different frequency band using EEMD. Then, the IMFs are reconstructed into a new signal by the weighted average method, called WAEEMD, based on Teager energy kurtosis (TEK). Finally, MSB is applied to decompose the modulated components in the reconstructed signal and extract the fault characteristic frequencies for fault detection. Furthermore, the efficiency and performance of the proposed WAEEMD-MSB approach is demonstrated on the fault diagnosis for a motor bearing outer race fault and a gearbox bearing inner race fault. The experimental results verify that the WAEEMD-MSB has superior performance over conventional MSB and EEMD-MSB in extracting fault features and has precise and effective advantages for rolling element bearing fault detection.
An Integrated Thermopile-Based Sensor with a Chopper-Stabilized Interface Circuit for Presence Detection
Authors: Moisello Elisabetta , Vaiana Michele , Castagna Maria Eloisa , Bruno Giuseppe , Malcovati Piero , Bonizzoni Edoardo
Published: September 2019

This paper presents a sensor-readout circuit system suitable for presence detection. The sensor consists of a miniaturized polysilicon thermopile, realized employing MEMS micromachining by STMicroelectronics, featuring a responsivity value equal to 180 V/W, with 13 ms response time. The readout circuit is implemented in a standard 130-nm CMOS process. As the sensor output signal behaves substantially as a DC, the interface circuit employs the chopper technique in order to minimize offset and noise contributions at low frequency, achieving a measured input referred offset standard deviation equal to 1.36 μ V. Measurements show that the presented system allows successfully detecting the presence of a person in a room standing at 5.5 m from the sensor. Furthermore, the correct operation of the system with moving targets, considering people either walking or running, was also demonstrated.
Parallel Computing for Quantitative Blood Flow Imaging in Photoacoustic Microscopy
Authors: Xu Zhiqiang , Wang Yiming , Sun Naidi , Li Zhengying , Hu Song , Liu Quan
Published: September 2019

Photoacoustic microscopy (PAM) is an emerging biomedical imaging technology capable of quantitative measurement of the microvascular blood flow by correlation analysis. However, the computational cost is high, limiting its applications. Here, we report a parallel computation design based on graphics processing unit (GPU) for high-speed quantification of blood flow in PAM. Two strategies were utilized to improve the computational efficiency. First, the correlation method in the algorithm was optimized to avoid redundant computation and a parallel computing structure was designed. Second, the parallel design was realized on GPU and optimized by maximizing the utilization of computing resource in GPU. The detailed timings and speedup for each calculation step were given and the MATLAB and C/C++ code versions based on CPU were presented as a comparison. Full performance test shows that a stable speedup of ~80-fold could be achieved with the same calculation accuracy and the computation time could be reduced from minutes to just several seconds with the imaging size ranging from 1 × 1 mm2 to 2 × 2 mm2. Our design accelerates PAM-based blood flow measurement and paves the way for real-time PAM imaging and processing by significantly improving the computational efficiency.
Implementation of the ISO 26000 Guidelines on Active Participation and Community Development
Authors: Licandro Oscar Daniel , Ramírez García Adán Guillermo , Alvarado-Peña Lisandro José , Vega Osuna Luis Alfredo , Correa Patricia
Published: September 2019

The ISO 26000 Guidance provides valuable conceptual and methodological guidelines for making corporate social action an effective tool through which organizations contribute to the solution of social problems within the communities they operate. These guidelines focus on their potential to contribute to the institutional strengthening of the social institutions of these communities, as well as to empower, generate autonomy, and develop skills in their final beneficiaries. Nevertheless, the academic literature has paid little attention to these guidelines. This document presents the results of pioneering research which was intended to provide information on the application of corporate social action. For measurement, a battery of 24 indicators was built and included in a structured questionnaire which was applied to a non-probabilistic sample of companies that carry out social actions. It was found that most of them apply the guidelines to a large extent and that this application correlates with the importance they assign to corporate social responsibility, with the degree to which they have incorporated it into their management, and with the construction of alliances with social organizations. Also, it was found that the application of these guidelines is independent of knowledge of the Guide and the approach to social responsibility that companies adopt.