bluuebunny/crossref_metadata_2025 huggingface dataset:
Modified persistence (mP) assay v1
Authors: JP JP. Lievens Eva
Published: June 2022

This protocol describes a modified persistence assay, as presented in the associated publication. The protocol is designed for chloroviruses, and should be applicable to other lytic viruses that are large enough to be counted by flow cytometry*. The protocol is a modification of the classic persistence assay: it uses predetermined virion concentrations and non-linear statistical modeling. Briefly, solutions containing 50000, 5000, 500, or 50 virions*/ml are prepared for each virus, these solutions are split into aliquots, and independent aliquots are used to do an MPN-like assay after 0, 7, 14, ... days. The MPN-like assay involves distributing the aliquots across 16 replicate liquid cultures of host cells (algae) and observing the number of cultures that are lysed. Statistical models are then used to estimate the initial concentration and decline of infectious virions. See the associated publication for a full description and schematic figure. *For viruses that are not large enough to be counted by flow cytometry, this protocol could be adjusted to start with different MOIs. It would then measure only the decline of infectious virions. Using materials that don't bind viruses is relevant for this protocol; see Materials for more information.
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Published: June 2022

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Authors: H Tzachi
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Isolation of nuclei from frozen tissue for ATAC-seq and other epigenomic assays v1
Authors: Corces Ryan
Published: June 2022

This protocol enables the isolation of nuclei from frozen tissues. These nuclei are suitable for use in ATAC-seq, single-cell ATAC-seq, ChIP-seq, HiC/3C, and many other assays.
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Authors: not provided bestcbdgummy
Published: June 2022

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NCBI submission protocol for foodborne virus surveillance v1
Authors: Yang Zhihui
Published: June 2022

INTRODUCTION: This protocol outlines the steps which ViroTrakr contributors need to follow in order to submit their data to NCBI. It includes how to: - establish your new BioProject at NCBI; - link it to ViroTrakr; - create BioSample numbers for your submission and submit raw sequence data to the SRA database; - submit assembled data to GenBank and link them to ViroTrakr (optional). ViroTrakr, a genomic database initiated by CFSAN and housed in NCBI, aims to (1) cover sequences of a wide range of foodborne viruses (e.g., norovirus, hepatitis A virus, sapovirus, etc.) from clinical, food and/or environmental specimens and (2) provide real-time reference sequences for phylogenetic analysis and epidemiologic studies linked to foodborne illnesses. Pipelines are under development with which ViroTrakr will eventually integrate to an international genomic reference database, GenomeTrakr, which has been successfully employed for bacterial pathogen surveillance in multiple countries. ViroTrakr: foodborne viruses (ID 396739) - BioProject - NCBI (nih.gov) GenomeTrakr: Multispecies (ID 593772) - BioProject - NCBI (nih.gov) Reference: NCBI submission protocol for microbial pathogen surveillance V.5: NCBI submission protocol for microbial pathogen surveillance (protocols.io)
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Authors: H Tzachi
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DNA Extract wash from filter paper stored at room temperature v2
Authors: Izenour Katie
Published: June 2022

Preservation of samples requiring cold-chain storage is an often unavoidable challenge especially when doing laboratory work outside the western world. Samples are a precious commodity and it is imperative to maintain their viability. One method for collection and storage of samples in a liquid form (blood, saliva, serum) at room temperature is on filter paper cards like the Cellabs Tropbio Filter Paper Blood Collection Disks™. Methods and protocols exist for the use and recovery of whole blood from filter paper discs. This protocol describes the wash and recovery of DNA extracted from whole blood using the Qiagen DNeasy Extraction kit and dried on filter paper, re-suspended after several months of room temperature storage and use in conventional PCR. This protocol was used to suspend DNA extracted from the wholeblood of Dogs in Cairo, Egypt. The DNA was extracted using the Qiagen DNEasy Extraction Kit and placed on Cellabs Tropbio Filter Paper Blood Collection Disks™ (filter paper). The DNA dried on the filter paper overnight and was stored in plastic self-closure baggies for several months before being washed off and used in Conventional PCR. The use case described here is of a dog who was PCR positive for Babesia spp. using a sample of whole blood washed from the filter paper as well as dried DNA from filter paper.
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Authors: not provided pengkoliyaa
Published: June 2022

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Authors: Hemp CBD Eagle
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Relationship of Blood Gas Measurements and Hematological Manifestations of COVID-19 Patients with Mortality: Retrospective Analysis
Authors: KILIÇKAYA Refika , ORAK Yavuz , ORAK Filiz , DOĞANER Adem
Published: June 2022

Objective: The aim was to investigate the relationship between blood gas and complete blood count parameters and mortality in patients with COVID-19 during and after in the intensive care unit (ICU).

Material and Methods: Patients were divided as group nonsurvivor and group survivor. Hematological parameters were registered on the day 1, 3, 5.

Results: A total of 142 patients were analyzed retrospectively in the study. Out of them, 46 were women (32%). Seventy-one patients were in group nonsurvivor (50%). The median age of group nonsurvivor patients was 61 years, and the median age of group survivor patients was 60 years. Noninvasive ventilation day and mechanical ventilation day were higher in group nonsurvivor. In group nonsurviver, at the admission to the ICU, in the third day and in the fifth day of ICU, PO2/FiO2 (p
CORRELATION OF RECEPTORS’ EXTRACELLULAR POOL AND IMMUNE RESPONSE LEVEL IN INDIVIDUALS LIVING IN ARCTIC CONDITIONS
Authors: Samodova A V , Tsypysheva O B
Published: June 2022

The paper has presented data on the study of a relationship of activity of the immune response and the accumulation of a pool of free molecules involved in the processes of cell cooperation, activation of immune cells and their apoptosis in villagers of Revda, the Levozersky District of the Murmansk Region. The study has involved 91 people, 77 women and 14 men aged from 21 to 55 years. In order to study correlation levels of the immune response and a free pool of receptors, the initial values i n the database have been divided into samples with high and low contents of free and membrane-selectin ligand; free protein cell adhesion sCD324; transferrinfree and membrane transferrin receptors; apoptosis protein sAPO-1 / Fas ligand sFasL. In the examined patients, there have been found high concentrations of IgA and IgM, there have been detected signs of retardation of a switch in synthesis from antibodies IgM to IgG. The identified pattern indicates a special role of cellular interaction by way of L-selectin in realization of IgE antibody formation. Accumulation of free L-selectin occurred almost at all stages of the immune response development, as well as during the increase in the content of CEA, due to activation of process reactivity in the mucous barrier. There has not been established influence of free transferrin receptor (sCD71) on the content of the membrane receptor for transferrin (mCD71), transferrin, and immunoglobulins, was probably associated with 2-fold concentration of regulatory T-lymphocytes (SD45RA). Accumulation of the free pool of receptors involved in the reactions of apoptosis of the immune competent cells was manifested by decreased activity of B-lymphocytes apoptosis, thus prolonging the period of antibody formation.
CYTOKINE REGULATION OF PROLIFERATIVE ACTIVITY OF PERIPHERAL BLOOD CELLS
Authors: Patrakeeva V P
Published: June 2022

The purpose of the research was to study effects of various cytokines on proliferation of peripheral blood white cells. There has been carried out an immunological examination of 234 healthy people aged 20 to 50 years, which included a study of immunograms, hemograms, neutrograms, monocytograms and lymphocytograms. In serum with use of ELISA method, there was determined content of tumor markers: carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP), as well as cytokines: IL-6, IL-4, IL-10, TNF-α and IFN-γ. The same type of inhibitory effect of elevated concentrations of cytokines, the mechanism of which is probably the induction of expression of tyrosine kinases has been shown. It has been shown that cytokines in concentrations that did not exceed the physiological norms and were close to the average content increased proliferation and differentiation of T and B-lymphocytes thus stimulating cell-mediated and antibody-dependent immune responses. High concentrations of proinflammatory cytokines lead to a sharp reduction in the number of peripheral blood cells with markers of both early and late activation of proliferation without further development of cell-mediated and antibody-dependent responses. Increased concentrations of IL-6 and TNF-α in blood serum more than 20 pg / ml reduced content of CEA and AFD, respectively.
ASSESSMENT OF PEPTIC ULCER INCIDENCE AMONG POPULATION OF EUROPEAN NORTH ОF RUSSIA
Authors: Nikiforova N A , Karapetyan T A , Dorshakova N V
Published: June 2022

The problem of the peptic ulcer disease is one of the most urgent problems in gastroenterology. In spite of modern achievements, this disease is very hard to nurse. The article has highlighted the results of the ulcer disease epidemiological research in the regions of the European North оf Russia in the period 2009-2013. The analysis of the data has shown that in five regions of the European North, the total and primary peptic ulcer incidence was above the average for the Russian Federation. In the Republic of Karelia (RK), the Komi Republic and the Arkhangelsk Region, the indicators of both the general and primary peptic ulcer incidence were the highest in the period 2009-2013. Karelia was the most disadvantaged region, where both the general and primary ulcer disease incidence was 1.4-1.6-fold higher than the average for the Russian Federation over the past five years. In the structure of the population mortality, diseases of the digestive tract consistently ranked fifth with the proportion 4.6-7.0% without a tendency to decrease.
RESPONSE OF HEMODYNAMICS INDICES TO HAND AND FOOT LOCAL COOLING IN YOUNG PEOPLE
Authors: Gudkov A B , Korobitsyna E V , Melkova L A , Gribanov A V
Published: June 2022

The article has introduced the examination results of apparently healthy men (n=27), who were born and permanently lived in the European North of Russia. The work objective was to discover peculiarities of the cardiovascular system response to local hand and foot skin cooling of the men. The preload rates of the cardiac muscle contractility, the afterload rates of functioning of the left ventricle and the rates characterizing hemodynamic status have been determined with the help of the hardware and software complex «Integrated Monitoring System SYMONA 111». The initial indexes and the indexes just after cold stress (dipping a hand into a vessel with cold water at temperatures of 24, 15, 8 °С) were registered. The same method and the same temperatures were used to cool feet. It has been shown that local hand and foot skin cooling caused a significant rise in the preload rates, the cardiac muscle contractility, the afterload functioning of the left ventricle, arterial pressure, and decreased the heart rate. During the hemodynamics indices analysis, the highest responsiveness of the cardiovascular system was registered after the local hand skin cooling in water at 15 0С, the lowest - in water at 24 0С. More pronounced changes occurred during the foot cooling.
INDICATORS OF PSYCHOPHYSIOLOGICAL ADAPTATION OF STUDENTS OF VARIOUS SOCIAL GROUPS
Authors: Notova S V , Alidzhanova I E , Kiyaeva E V , Akimov S S
Published: June 2022

The results of research of some psychological and psychophysiological indicators of students of various social groups (orphan students and students from usual families) in the course of adaptation to university training have been presented. Assessment of psychophysiological parameters was carried out with application of the standardized, approved techniques (A. Bass and A. Darki's technique adapted by A. K. Osnitsky: attention assessment, a test for noise stability). The conducted research has revealed reliable differences in psychophysiological characteristics of the students from various social groups. "Verbal aggression", "sense of guilt" and "the aggression index" were significantly lower (by 10.0; 25.0 and 4.5 % respectively) in the orphan students in comparison with the girls from the usual families. Psychophysiological tests "Attention assessment" and "Noise stability" have revealed a low degree of noise stability in the examined girls of both groups. "Physical" and "indirect aggression" were significantly higher in the orphan students. The test "Noise stability" has identified lower indicators of response time in the orphan students (by 7 %) and the system lower functional level (by 8 %). The correlation analysis has shown the nature of the interrelation of noise stability and the students' individual and psychological features. The received results demonstrate the necessity of the students' adaptation processes monitoring for timely arrangement of medical-preventive actions.
INDICATORS OF SUSTAINABLE DEVELOPMENT AND SOCIETY’S LIFE QUALITY: PROBLEMS OF CHOICE AND ADEQUACY
Authors: Leshchenko Ya A
Published: June 2022

Some indices widely used in the world practice for assessing the level of development and society's life quality have been considered in this paper. The indices like the gross home product, the index of human potential development have been assessed from the critical position. A number of indices and criteria, which, in the author's opinion, may be used as comparatively objective indicators of state of the most important elements of the socio-ecologo-economic systems have been characterized. Some aspects of life quality in the Russian society in the post-soviet period have been covered from the position of balanced development: very low salary level, growing socio-economic inequality, loss of strategic positions in the defensive-technical sphere, loss of competitive positions in the spheres of scientific and technical development.
SYNERGETIC BIOPSYCHOSOCIOSPIRITUAL CONCEPTION OF MENTAL EPIDEMICS OF PSYCHOSOMATOSES
Authors: Sidorov P I , Sovershaeva E P
Published: June 2022

A mental pandemy of psychosomatoses is consistently developing in singular and stress-producing reality. There has been proposed a synergetic biopsychosociospiritual conception of epidemic psychosomatic disorders, including three prenosological fractals of development: predisposition - a psychosomatogenic family, latent - psychovegetative diathesis, initial - a functional disorder, and three nosological fractals: a full-scale clinical picture - a mental epidemic, chronization - a destructive mental epidemic, an outcome - a pandemy. There has been grounded a block-modular approach to development of multidisciplinary programs and patient-specific medical-preventive routes of mental medicine. Its mission consists in adaptive engineering and management of consciousness and health. Its enables to plan and reconstruct mental immunity as the matrix of identity and security base.
CHANGES IN SOCIO-PSYCHOLOGICAL CLIMATE, TEAM’S MOOD AND EXPEDITION MEMBERS’ STATUS IN DYNAMICS OF AN ARCTIC VOYAGE
Authors: Porokhina I A , Voytekhovich T S , Simonova N N
Published: June 2022

Objective: To study the dynamics of socio-psychological climate and mood of the team, a functional status of an expedition members during an Arctic voyage. Methods: psychological testing, observation. Type of study: observational, descriptive. Sample: members of the expedition "Arctic Floating University 2013", 38 people. Statistical methods: descriptive statistics, ANOVA with repeated measurements, the Friedman χ 2- criterion. Conclusions: 1. Knowledge of the features of the expedition team members composing the group formed for the first time increased from the beginning to the end of the voyage. 2. The expedition duration (25 days) was not sufficient for the team to reach the stage of functional-role correlation. Development of the group unity did not significantly affect the team mood due to the onset of fatigue because of communication and work in monotonous conditions. 3. The features of the change of the expedition members' functional status were as follows: the delayed lowering of self-rating of the states (initially human condition itself worsened); the phase of reversing trends preceded the phase of resource use optimization; the phase of "waiting for the voyage end" was separated; during the voyage, specially arranged emotional events affected the participants' self-rating of the functional states; the changes in the states during the voyage did not have a large amplitude, in their manifestation was not extreme.
ECOLOGY OF CHILDHOOD: FACTOR OF CULTURE, EDUCATION AND PROFESSIONAL COMPETENCE OF TEACHERS
Authors: Wagner I V , Tkacheva A N
Published: June 2022

A culturological perspective of problems of ecology of childhood; approaches to formation of a problem field of childhood ecology in the context of development of ideas about the phenomenon of childhood and its transformation in the global world conditions, importance of cultural factors, education and professional competence of teachers in ecologization of childhood space, implementation of subjective potential of childhood in the big cultural creativity process on the basis of eco-cultural values have been grounded. It has been emphasized that environmental problems are not limited to the problem of childhood, environmental security, which in themselves are paradoxical (the need to protect people from the consequences of the environmental crisis generated by them). The problems make obvious the need to find causes of environmental problems in human culture and society, and their solution - in formation of a new cultural code based on interiorization by personalities and society of ecocultural values, their ecological culture.
CHAOTIC DYNAMICS OF CARDIOINTERVALS IN THREE AGE GROUPS OF INDIGENOUS PEOPLE OF UGRA
Authors: Garaeva G R , Eskov V M , Eskov V V , Gudkov A B , Filatova O E , Khimikova O I
Published: June 2022

Human ecology deals with a very important issue of life expectancy of indigenous people and new comers of the northern parts of the Russian Federation. The faster the northern territories are developed economically and industrially, the higher importance of prolongation of working age of new comers in the Khanty-Mansiysk Autonomous Area - Ugra and the Yamal-Nenets Autonomous Area is. There are four possible variants of new comers' life prolongation. Through the example of three age female groups of indigenous population, there has been considered the problem of dynamics of changing heart rates. In phase space of states, increased volumes of quasiattractors are equal to intensive physical activity. It has been proposed to use the regularity of these volumes' decrease for assessment of human aging dynamics in the North.
THE CORRELATION BETWEEN CONSTITUTIONAL TYPES AND GROWTH RATES OF GIRLS FROM WESTERN SIBERIA
Authors: Filatova O V , Pavlova I P , Vascheulova I V , Kovrigin A O
Published: June 2022

TA cross-sectional anthropometric study of 660 girls aged 7 to 17 years, residents of the City of Barnaul and the Altai Krai countryside, has been conducted. There have been detected differences of the girls' physical status depending on their residence in the urban or rural areas of the Altai Krai. The differences were represented by the greater body length (166.8 ± 6.28 cm in the city and 164.8 ± 5.36 cm in the village) and leg length (88.2 ± 6.06 cm in the city and 84.1 ± 4.21 cm in the village) of the townsgirls. The girls from the city had a significantly greater body and leg length throughout the period of the study. The longer lower limbs in relation to the torso and, correspondently, the lower values of the trochanter index were a result of the increasing rate of the prepubertal growth of the girls - residents of the city. A somatotypological analysis has revealed predominance of the normosthenic somatotype among the examined girls. In the city 50% of the girls had the asthenic somatotype, 41 % - the normosthenic somatotype, 9 % - the hypersthenic somatotype. 81 % of the rural girls had the normosthenic somatotype, 8 % - the hypersthenic somatotype, 11 % - the asthenic somatotype. The representation of the persons with the andromorphic somatotype decreased with the trochanter index increase.
AGE FEATURES OF CARDIOVASCULAR SYSTEM FUNCTIONAL PARAMETERS IN ADOLESCENTS LIVING IN DIFFERENT ARCTIC AREAS
Authors: Demin D B , Poskotinova L V , Krivonogova E V
Published: June 2022

Age features of autonomic nervous regulation of cardiac activity in 426 healthy adolescents aged 14-17 years living in areas of different latitudes, climatic and ecological conditions of the European North - in the Subpolar (64°30' N) and Polar (67°40' N) areas have been detected. Assessment of the cardiovascular system status was carried out with the use of the heart rate variability (HRV) and blood pressure (BP) parameters. The share of persons with borderline hypertension (BP level exceeded the limit of 90 percentile) also increased with age and reached 63% by the age of 17 years. Among the adolescents living in the Polar region according to the HRV and blood pressure indices, there was registered a significant increase in the proportion of persons with a predominance of sympathetic influences on the heart activity. The greatest adrenergic effects on the cardiovascular system were found in the 15-year-old adolescents of the Polar region, they had higher indices of systolic blood pressure, the heart rate and the regulatory systems stress index, as well as lower total HRV spectrum power in comparison with the 15-year-olds adolescents living in the Subpolar region.
PREVENTION OF ORGANIZATIONAL STRESS IN LAW ENFORCEMENT OFFICIALS
Authors: Korehova M V , Novikova I A , Soloviev A G
Published: June 2022

In order to develop approaches to prevention of organizational stress (OS) in law enforcement officers, 155 police officers have been examined. It has been revealed that one third of them had a high level of OS and were characterized by low adaptive capacity, signs of psychological maladjustment, symptoms of professional burnout. Basic principles for prevention of OS in law enforcement officers with separation of professional-organizational, social and individual-psychological areas of work contributing to formation of their high psychological stability have been grounded.
SYNERGETIC BIOPSYCHOSOCIOSPIRITUAL CONCEPTION OF DIABETES MENTAL EPIDEMIC
Authors: Sidorov P I , Sovershaeva E P
Published: June 2022

Diabetes is a burning medical-social epidemic of the contemporary world. At the maximum level of generalization, it can be considered as a hedonistic mentality trap of "dolce vita" of the consumer society.
Diabetes requires development of a multidisciplinary approach to etiopathogenesis and clinical findings, preventive-correctional and medical-rehabilitation aid. There has been proposed a synergetic conception of Diabetes including three prenosological fractals: predisposition - a diabetogenic family, latent - diabetogenic diathesis, initial - pre-diabetes, and three nosological fractals: an onset, chronization and an outcome. There have been grounded mechanisms of development of a Diabetes mental epidemic and a program of medical and psychosociospiritual aid.
EPIDEMIOLOGY AND RISK FACTORS OF CHRONIC CEREBROVASCULAR DISEASES AND ISCHEMIC STROKE IN CLIMATIC CONDITIONS OF THE NORTH OF WESTERN SIBERIA
Authors: Bogdanov A N , Karpin V A
Published: June 2022

An analysis of the chronic cerebrovascular diseases' structure and prevalence, as well as morbidity, mortality and risk factors for ischemic stroke in the Middle Ob region of Western Siberia for the period 1989-2010 (Surgut) has been done. The cardiovascular diseases prevalence in the adult population was 73.4 %, among which there predominated arterial hypertension (46.1 %). There has been revealed increased morbidity and mortality from stroke during the whole study at a level exceeding the observed regions of European Russia. An analysis of risk factors showed growing pathogenetic significance of arterial hypertension, coronary heart disease and diabetes with a relatively stable value of other recognized risk factors of disease progress. The leading role of arterial hypertension in formation of an acute period of stroke has been shown. A program of objective phased identification of patients from the stroke risk group and their active rehabilitation has been proposed.
PHYSICAL DEVELOPMENT OF CHILDREN AGED 9-11 YEARS - NATIVES OF MIDDLE OB AREA
Authors: Litovchenko O G , Ishbulatova M S
Published: June 2022

The Physical Development (PD) of children - the major indicator reflecting influence endo- and exogenous factors on health of children's population. Dynamic monitoring over PD of children allows to estimate the phenomena occurring in society and environment. Results of research of physical development of 200 children of primary school age (9-11 years old) - natives of the Middle Ob area depending on a sex and age are presented. It is established that in all age groups prevail children with the average level of PD and normal body weight, but regional features are available, however: it is more school students with excess of body weight, than with its deficiency, both among boys and girls; the total sizes of a body changed within all-biological regularities, characteristic for this piece of ontogenesis, in 9 and 10 years difference on body length of boys and girls were absent, and "growth jump" was observed further, and from 11 years old girls started being ahead of boys on this indicator.
CORRELATION OF SF-36 SUB-SCALES AND INDICES OF STRESS-COPING BEHAVIOR IN STUDENTS OF NORTHERN MEDICAL INSTITUTION
Authors: Shalamova E Yu , Safonova V R
Published: June 2022

We have analyzed relationships between stress-coping behavior styles and subjective well-being of the first year students of the Medical Faculty of the Khanty-Mansiysk State Medical Academy, 57 girls and 22 boys. We did a statistical analysis with Statistica 8.0 for Windows in view of sign normal distribution. The boys had better results according to the sub-scales Physical Functionality (PF), Vitality (VT) and Mental Health (MH). The girls used the sub-style Diversion more often. For the girls, there was a bigger number of statistically significant correlations between the sub-scales of the SF-36 questionnaire and the stress-coping behavior. According to the scales of physical components, there have been found significant correlations in the girls according to the sub-scale General Health (GH), and in the boys - according to the sub-scale Physical Role Functioning (RP). The use of the emotionally focused stress-coping styles in both groups was combined with a decrease in the values of the individual sub-scales of the SF-36 questionnaire. On the contrary, the choice of the problem-oriented and avoidance-oriented coping styles and its sub-styles was combined with their increase.
LEECH THERAPY IN TREATMENT OF CARDIOVASCULAR DISEASES
Authors: Konyrtaeva N N , Grjibovski A M , Kausova G K , Zhernov V A , Kalmataeva Zh A
Published: June 2022

The aim of this review was to summarize the evidence on the effectiveness of Leech therapy in treatment of cardiovascuLar diseases. This assessment is based on the analysis of results of clinical trials conducted in 2000-2015 and published in peer-reviewed literature indexed in PubMed, ISI Web of Science, Scopus, E-library.ru and E-library.kz databases. The paper presents a review of the current controlled and uncontrolled studies ensured evidence-based information about the effectiveness of leech therapy in the treatment and prevention of complications of coronary heart disease, hypertension, chronic heart failure and stroke. In discussion, we demonstrate the rationale for leech therapy from the evidence-based point of view. We conclude that the current evidence is considered sufficient for using leech therapy as a complementary method in treatment of cardiovascular diseases and prevention of their complications as a part of the conventional therapy. According to the official recommendations on the use of leech therapy in healthcare issued by the Ministry of Health of the Russian Federation from 2002, the list of indications for leech therapy include coronary heart disease, early stages of heart failure, cardiosclerosis, cardialgias, dyscirculatory encelopathy and arterial hypertension. However, leech therapy should not be used as a substitute for standard treatment schemes of the abovementioned conditions.
EFFECT OF FOOD CHEMICAL COMPOSITION ON POPULATION HEALTH IN OMSK REGION
Authors: Turchaninov D V , Turchaninova M S , Brusentsova A V , Rezanova N V
Published: June 2022

With the application of the method of risk assessment, there have been studied effects of chemicals in food on the population health in the Omsk region in the period 1996-2012. The level of contamination of food with chemical carcinogens increased in the periods 1996-2004 and 2009-2012. The population carcinogenic risk was 5 х 10 -4 and 6.6 х 10 -4 respectively (the levels unacceptable for the population on the whole). The risk of noncancer effects was assessed taking into account influence on the critical organs (systems). The value of the hazard index (HI) > 1 (not acceptable) in the period 1996-2004, was received for the effects on the nervous system (central and peripheral), the cardiovascular system and skin; in the period 2009-2012, the critical organs and systems were the endocrine, cardiovascular, central nervous, urinary systems, the gastrointestinal tract, the blood system, the immune system, skin. Generally in the period 1994-2012, the levels of toxicants' effects in food increased, what caused an increased number of the organs (systems) - targets. Due to the content of chemicals, mainly arsenic, the main food groups with adverse effects on the human body were bakery goods and products of grain processing.
NEURAL EMULATORS IN IDENTIFICATION OF ORDER PARAMETERS IN HUMAN ECOLOGY
Authors: Eskov V M , Filatova O E , Provorova O V , Khimikova O I
Published: June 2022

Binary classification offers the procedure of identification of more significant x i diagnostic features (order parameters) for the systems being in different conditions and divided by a neural emulator. Ranking of x i is realized by many repetitions (p > 100) of problem solving of binary classification by a neural emulator at initial set of feature weights w j io where j is an iteration number (i = 1, 2 ... p) from the interval (0, 1) with an uniform distribution. Accuracy of identification increases by increased p (p > 1 000, p > 10 4), that is demonstrated on parameters of cardiovascular system of groups of people working at night shifts.
MICROECOLOGICAL STATUS OF UPPER RESPIRATORY WAYS MUCOSA IN TEENAGERS LIVING IN TOWNS WITH CHEMICAL INDUSTRY
Authors: Nesmeyanova N N , Sosedova L M
Published: June 2022

The complex studies on assessing the microecological status of the upper respiratory ways (URW) have been performed in schoolchildren of senior classes living in centers of chemical industry. Some features of adaptive-compensatory responses of the immune system have been determined. The result analysis of the microecological and immunological studies of the respiratory tract allowed to detect inhibition of the respiratory ways colonizational resistance, changes in the qualitative properties of the microorganisms, decreased local immunity of URW and common organism resistance. Disorders of the microecological status of the teenagers' respiratory ways mucosa in body disadaptation can result in development of clinically pronounced pathologies and aggravation of the respiratory organs' diseases.
SYNERGETIC BIO-PSYCHO-SOCIO-SPIRITUAL CONCEPTION OF SOCIAL EPIDEMIC OF ONCOLOGY DISEASES
Authors: Sidorov P I , Sovershaeva E P
Published: June 2022

Oncology diseases (OD) are multiple-factor and polygenic diseases, they lie in one of the first places in the disease structure, disability and mortality prevalence. There has been proposed the synergetic OD conception including three prenosological fractals: predisposition - an oncogenic family, latent - oncogenic diathesis, initial - precancer, and three nosological fractals: a full-scale clinical picture, chronization and an outcome. The multidisciplinary team medico-psycho-socio-spiritual program of preventive-correctional and medical-rehabilitation aid has been grounded.
MENINGOCOCCEMIA IN CHILDREN: FACTORS INFLUENCING OUTCOME
Authors: Samodova O V , Krieger E A , Titova L V , Bogdanova A V
Published: June 2022

Systemic meningococcal infection requires prompt and adequate medical care. It is considered as an unpredictable disease due to extreme severity of patients' condition and high risk of fatal outcome. The study was aimed to investigation of factors influencing outcomes in children with meningococcemia. Cox regression analysis was applied to estimate effects of age, septic shock, neutropenia, and use of glucocorticoids at the pre-admission stage on the risk of a fatal outcome. The retrospective cohort included all cases of meningococcemia in children that arose in the Arkhangelsk region in 1991-2013. Altogether, 90 children (35 girls and 55 boys) with meningococcemia were included in the study. All death cases occurred during the first three days of illness. The average age was 1 year 2 months. The age younger than 1 year was not associated with fatal outcomes, HR 1.0, 95 % CI 0.5-2.1. The factors influencing outcomes were septic shock, HR 11.9, 95 % CI 1.6-89.2, and neutropenia, HR 1.6, 95 % CI 1.2-2.1. Rapid diagnosis and management of septic shock is critical for successful treatment. Use of intramuscular or intravenous injections of glucocorticoids at the pre-admission stage according to the common recommendations did not improve the outcomes, HR 1.2, 95 % CI 0.6-2.4.
SYNERGETIC BIO-PSYCHO-SOCIO-SPIRITUAL CONCEPTION OF PEPTIC ULCER SOCIAL EPIDEMIC
Authors: Sidorov P I , Sovershaeva E P
Published: June 2022

The Peptic Ulcer (PU) social epidemic comprises one tenth of adult population of the globe. The PU polygenic nature required development of the synergetic bio-psycho-socio-spiritual conception that allowed to specify three prenosological fractals: predisposition - ulcerogenic family, latent - ulcerogenic diathesis, initial - a preulcerous state, and three nosological fractals: a full-scale clinical picture, chronization and an outcome. There have been proposed criteria of a social PU epidemic, a destructive social epidemic and a pandemy. The multidisciplinary program of preventive-correctional and medical-rehabilitation aid has been grounded.
HEAT WAVES AS REFLECTION OF VARIABILITY OF CURRENT CLIMATIC CONDITIONS OF VITAL ACTIVITY IN TOMSK REGION
Authors: Kuzhevskaya I V , Polyakov D V , Volkova M A , Barashkova N K
Published: June 2022

An analysis of heat waves in the Tomsk region has been conducted. There has been presented an analysis of the frequency of occurrence of heat waves in summer seasons, including waves, during which the average maximum air daily temperature exceeded the average maximum air temperatures at the stations; there have been established individual characteristics of waves: length and intensity. It has been shown that the longest waves were characteristic of the northern part of the region that corresponded to the probability of occurrence of such phenomena once every 100-300 years. The revealed quantitative indicators and trends of heat waves manifestations indicated a probability of an increased number of health deterioration cases of the regional population in future years.
Sinergeticheskaya biopsikhosotsiodukhovnaya kontseptsiya sotsial'noy epidemii bronkhial'noy astmy
Authors: Sidorov P I , Sovershaeva E P
Published: June 2022

Bronchial Asthma (BA) is a widespread social epidemic of the contemporary world, resulting in severe complications and enormous economic expenses. There has been proposed a synergetic bio-psycho-socio-spiritual BA conception, including three prenosological fractals predisposition - an asthmogenic family, latent - asthmogenic diathesis, initial - preasthma, and three nosological fractals: a full-scale clinical picture, chronization and an outcome. The multidisciplinary team organization of preventive-correctional and medical-rehabilitation aid has been grounded.
THE MULTIFACTORIAL ASSESSMENT OF CARCINOGENIC EFFECTS OF ENVIRONMENTAL FACTORS
Authors: Manzhurov I L , Lezhnin V L
Published: June 2022

Objective: Assessment of effects of environmental factors on development of lung cancer. Methods: We applied a multiple factor approach to designing the epidemiologic study. The object of our research was the town of Karpinsk, the Sverdlovsk Region, situated within the environmental radiochemical area with a high radon potential characterized by a moderate level of contamination of the natural environment and high cancer incidence rates among the local population. The case group included 142 lung cancer patients and the control group consisted of 220 people without cancer. We analyzed health effects of 12 biological, social, occupational, and environmental factors. We used the deterministic algorithms of pattern recognition for the multifactor data processing. Results: We have established the power and nature of the effect of each factor under study on development of lung cancer. Using mathematical modeling, we assessed efficiency of hypothetical scenarios of some risk factors correction. Conclusions: Among the lung cancer environmental risk factors in Karpinsk, indoor air pollution with carcinogenic brown coal combustion products was of great importance; the contribution of indoor exposure to radon isotopes was low (0.9 %).
SYNERGETIC BIO-PSYCHO-SOCIO-SPIRITUAL CONCEPTION OF ARTERIAL HYPERTENSION
Authors: Sidorov P I , Sovershaeva E P
Published: June 2022

Arterial hypertension (AH) is an ultimate non-infectious pandemic in human history that determines the cardiovascular morbidity and mortality structure. Despite significant advances in understanding the disease pathogenesis and modern strategies in hypertension management, it is still one of the most relevant medical social problems that require development of a multidisciplinary approach to etiopathogenesis and clinical picture, preventive-correctional and medical-rehabilitation aid. A synergetic conception of AH including three prenosological fractals: predisposition - hypertensive family, latent - hypertensive diathesis, initial - prehypertension, and three nosological fractals: onset of disease, chronization and outcome, has been proposed. The mechanisms of development of the AH social epidemic and the program of medical-psycho-socio-spiritual aid have been grounded.
CHARACTERISTIC OF RESPIRATORY SYSTEM COMPENSATORY-ADAPTIVE REACTIONS IN MILITARY MEN OF SPECIAL TASK UNITS IN DYNAMICS OF SERVICE AND FIGHTING TASKS PERFORMANCE
Authors: Gudkov A B , Beskaravainy E B , Popova O N , Sarychev A S
Published: June 2022

There have been studied separate compensatory-adaptive reactions of the respiratory system in 39 military men of special task units in dynamics of service and fighting task performance. It has been established that organism’s abilities of adaption to organization of necessary functional structures with its stable preservation in optimum state resulted in development of compensatory adaptability of the military men’s respiratory system regardless of the length of their service. The received results allowed to suggest dependence of compensatory- adaptive reactions of the military men’s respiratory system on the nature of the service and fighting tasks performance with possibility of full recovery at the end of 1 month after the return of the military men to the permanent base without carrying out of additional rehabilitation measures.
COVERAGE OF PREFERENTIAL POPULATION GROUPS FOR ANTIHYPERTENSIVE MEDICINES IN ALMATY, KAZAKHSTAN
Authors: Abuov D Zh , Grjibovski A M , Kalmantaeva Zh A , Stepkina E S , Rustemova A Sh
Published: June 2022

The aim of this descriptive study was to assess the coverage of preferential population groups for antihypertensive medicines in Almaty, the former capital of Kazakhstan. We present the data on the coverage of preferential population groups for the period from 2008 through 2012. The absolute number of residents who were covered for antihypertensive medicines increased from 31814 to 73518. Financial resources allocated by the state to cover the privileged population of Almaty for antihypertensive medicines increased from 28 188 714 KZT (233 423, 86 USD) in 2008 to 223 050 004 KZT (1 492 720,67 USD) in 2012 which corresponds to per capita increase from 7,34 USD in 2008 to 20,3 USD in 2012. The next step which we plan to make in a few years from now is to assess whether these measures has led to decrease in mortality from hypertension and from diseases of circulatory system in general.
NON-PARAMETRIC TESTS FOR TWO PAIRED SAMPLES USING STATA
Authors: Kharkova O A , Grjibovski A M
Published: June 2022

In this paper we describe the use of non-parametric tests for comparisons of two paired samples. The authors present examples of manual calculation of Wilcoxon’s signed rank test and sign test as well as the use of STATA for calculation of the abovementioned statistical tests. We present assumptions for use of non-parametric tests for paired samples and recommendations on how to present the results in scientific publications.
HEAVY METALS IN THE ARCTIC SOILS OF THE WESTERN COAST OF SVALBARD ARCHIPELAGO
Authors: Kryauchyunas V V , Iglovsky S A , Shakhova E V , Malkov A V
Published: June 2022

Accumulation, migration of heavy metals in the Arctic soils of the western coast of the island West Spitsbergen have been studied. The main ways of heavy metals intake to the soil have been established. The raised concentration of strontium in the Arctic soils of the archipelago is induced by its natural concentration in maternal deposits.
DYNAMICS OF THE INCIDENCE AND MORTALITY OF COLON CANCER IN 2000-2010 IN ARKHANGELSK REGION (POPULATION STUDY)
Authors: Lebedeva L N , Valkov M Yu , Asakhin S M , Krasilnikov A V
Published: June 2022

Objective. To give medical and ecological evaluation for the epidemiology of colon cancer (CC) between 2000 and 2010 in Arkhangelsk oblast (AO) by the data of regional population cancer registry (ARCR). Materials and methods. Data on all cases of CC (C18.0-C18.9) in the AO in 2000-2010 were extracted from the database of the ARCR. The incidence and mortality from CС by sex, age, place of residence and tumor location studied. Adjustment for age was performed using WHO 2000 age standard. Data on population number were extracted from Arkhangelskstat. Results. Over the study period, 3267 cases of the CC were registered. Crude and standardized CC incidence increased during the period by 44.3% and 27.44, respectively. Mortality from CC in 2010 was 12.5 per 100 000 population. Epidemiological indicators are higher than in average in Russia, showing the same dynamics. Probability to get CC progressively elevates with age accounting 5.5 and 8.1 vs 190.3 and 142.3 per 100 000 male and female population at age 40-49 vs 70 years and older, respectively. Crude CC incidence in AO is higher in the female population while standardized one was higher among males. This is explained by a much smaller proportion of the males in older age groups and confirms the importance of standardization. The CC incidence rates are lower in rural population comparatively to urban one. Levels and trends of CC incidence among inhabitants of cities with pulp and paper plants were similar to that in other cities of AO. Conclusions. Epidemiological model for CC in both AO and Russia in whole shows progressively increasing incidence and mortality with relatively small gap between them and substantially differs from that in developed countries. Pulp and paper industry does not influence on CC incidence.
PHYSIOLOGICAL BASIS OF THE FUNCTIONAL BIOFEEDBACK METHODS
Authors: Demin D B , Poskotinova L V
Published: June 2022

The review contains a definition and the essence of biofeedback functional methods. The historical, scientific aspects and the main hypotheses are given here explaining the mechanisms of biofeedback. Different techniques and methods of biofeedback are discussed, as well as the scope of the rapidly developing technology of biofeedback. Emphasis is put on physiological mechanisms and prospects of heart rate variability biofeedback methods of development.
SOCIAL-HYGIENIC ASPECTS OF POPULATION HEALTH OF PRIMORSKY KRAI POPULATION
Authors: Kiku P F , Yarigina M V , Geltser B I , Gorborukovd T V
Published: June 2022

A sociological survey (questioning) of residents of the Primorsky Krai with different demographic, environmental and social characteristics: of urban and rural areas, coastal and continental bioclimatic zones has been held. On the whole, 2113 people have been interviewed. The questionnaire contained 31 questions for determination of the degree of the population awareness about impact of different environmental factors on health. For processing of the sociological information (the questionnaires), there was used the method of mathematical рleiades by P.V. Terentiev. On the basis of the method, there has been developed a program of processing of sociological information for computers. The studied system was divided into three subsystems according to the model points. An analysis of the questioning results with use of the method of mathematical рleiades has allowed to detect a connection between social-hygienic factors and the population health
MENTAL HEALTH SERVICE
Authors: Sidorov P I
Published: June 2022

In the article, there have been considered after-effects of the crisis of Descriptive Psychiatry and there have been grounded economically effective strategies of mental health services development. There have been selected principles of organization and functions; a synergetic medical-psychosocio-spiritual methodology of functional diagnosis and quality improvement of multidimensional adaptation; individual preventive-correctional and medical-rehabilitation programs and routes, interdisciplinary protocols and early interventions; approaches to improvement of quality, levels and styles of life by means of system integration of its healthy image and moral sense; features of organization of multidisciplinary brigades in mental pediatrics.