bluuebunny/crossref_metadata_2025 huggingface dataset:
Localizing Black History
Authors: Taylor Mandy
Published: August 2023

I selected localizing Black history as my research area of focus as growing up a mixed person of colour, I rarely learned about Black history within local contexts as I will introduce you to within this project. Though not taught the full scope of Canadian history during my time as a student in the NCDSB (Niagara Catholic District School board), I was one of the lucky few whose parents took the time to provide tid bits of information about the rich Black History Fort Erie and the Greater Buffalo Niagara region is home to. My goal and aim with this project is to eliminate future students walking down the streets of their hometowns not knowing about the incredible history around them. The research methodology used for this project was performed primarily through archival research at the Fort Erie Historical Museum, the African Corridor in Buffalo NY, as well as online discovery research. However, in order to grasp the gaps missing in current education, and what avenue to take with the product of the project I took advisement from local Black champions pushing for Black education. In my findings most of the past education surrounding Black History in schools until recently has been plagiarized from America. While these two nations share a deep-rooted history, for far too long has Canada has adopted the same Black history narratives as the US, highlighting amazing Black change makers such as Rosa Parks and Martin Luther King; however, it has failed to mention Canada’s change makers. Currently, there has been an influx to introduce some of Canada’s Black history into “The Ontario Curriculum;” however, just the word “Black,” is only mentioned 14 times for grades 3 – 8, to compare the word “British” which is used 63 times. While the curriculum mentions Black history 14 times, it is not always taught, and is usually a topic, module, or unit that is ‘missed,’ in order to ensure the central focus of the course is completed in its entirety. The archival research completed for this project and subsequent curriculum developed demonstrates the rich local Black history of the Fort Erie and Greater Buffalo Niagara region for those living within these areas and will provide middle school educators with a way in which to introduce this rich history to students in this region.
Can Cheap Talk Eliminate the House Money Effect in Apple Experimental Auction?
Authors:   The Korean Agricultural Economics Association, Ryoo Yang-Hyung , Kim Se-Hyuk , Kim Se-Hyuk
Published: August 2023

In the experimental auction, participation fees can cause a house money effect that makes the value of the product higher than the actual value. The purpose of this study is to analyze whether the house money effect can be eliminated in experimental auctions by applying cheap talk used in contingent valuation and choice experiment to reduce hypothetical bias. For the analysis, an experimental auction is conducted by organizing five different auction products depending on whether or not to provide information on the taste of apples, method, color, and sugar content. The number of experimental groups is 8, and four groups provide a cheap talk, and four groups do not. The number of bidders per group is about 15, and the number of rounds is 9. The results show that it has been empirically verified that cheap talk can eliminate the house money effect. The results also indicate that as the auction round progresses, the younger the age or the lower the education level, the greater the effect of removing the house money effect of the cheap talk. Since cheap talk is easily applicable and effective, the use of cheap talk is recommended in studies using experimental auction.
Assessing the effects of changes in Hanwoo breeding cow population on equilibrium using Multimarket Partial Equilibrium model
Authors:   The Korean Agricultural Economics Association, Kim MinKyoung , Mun Hong Sung , Jeong Kyeong Soo
Published: August 2023

A vertically integrated structure was considered in developing a Multimarket Partial Equilibrium Model for the Hanwoo industry. In order to eliminate the supply effect on the final demand for Hanwoo beef, Hanwoo beef demand index was constructed and integrated into the model. Using simulations that altered the number of breeding cows, the model was utilized to examine the ripple effect on equilibrium quantity and price, which are crucial in regulating the supply and demand of Korean beef. The study found that altering the number of breeding cows affected the feeder and fed cattle markets depending on the timing of the alteration to the breeding cow population. Fattening breeding cows is a significant tool that directly impacts market equilibrium but caution is needed when implementing this policy as it cannot be considered a fundamental measure for stabilizing the Hanwoo supply.
Characteristic of Vibration Signal from Cutting Tool Against Steel ST60 for CNC Turning Monitoring System
Authors: Fachrul Muh , Aminy Ahmad Yusran , Hayat Azwar
Published: August 2023

Kondisi insert secara signifikan mempengaruhi kualitas produk dan efisiensi pembuatan mesin bubut. Studi ini menggunakan distribusi kerapatan spektral daya dari sinyal getaran accelerometer mesin bubut CNC untuk merancang sistem klasifikasi kondisi sisipan pahat yang dapat diterapkan pada kondisi pemesinan yang berbeda. Untuk empat kondisi sisipan pemesinan bubut yang umum (yaitu tepi terpasang, keausan flank, normal, dan fraktur), Dalam hal ini, sistem klasifikasi kondisi sisipan dibuat dengan dua tahap—pemodelan kondisi sisipan dan fusi model pemesinan. Pada tahap pemodelan kondisi insert, fitur magnitudo frekuensi tersegmentasi ditangkap menurut distribusi kerapatan spektral daya dari sinyal getaran akselerometer. Root mean square error (RMS) dan Fast Fourier Transform (FFT) dihitung untuk melakukan studi prediksi getaran menggunakan alat potong bubut. hasil sinyal mentah pada kondisi percobaan baru, nilai RMS berada pada kisaran 6,24-6,23, dan FFT 0,0007-0,0009. kondisi baik, kondisi sinyal mentah menunjukkan nilai RMS berada pada kisaran 54.36-67.08 dan FFT 0.0068-0.0080, kondisi sinyal mentah sedang, nilai RMS 83.05-112.07, dan nilai FFT 0.0089-0.0147, buruk Kondisi raw signal nilai RMS 125.14-152.09 dan nilai FFT 0.0137-0.0178. Dapat disimpulkan bahwa data terbaik yang dapat digunakan untuk proses prediksi kerusakan mata alat menggunakan metode cluster data dengan menggunakan nilai tegangan RMS pada sinyal mentah dan magnitudo pada proses FFT adalah data pengukuran tegangan RMS untuk sinyal mentah karena data sinyal mentah menyediakan rentang pengukuran yang luas. berbanding lurus antara kerusakan bilah alat dan peningkatan voltase di RMS, dan cluster data dikelompokkan dengan baik.
Thermal Sensation Analysis in the Building of Universitas Ichsan Gorontalo
Authors: Abay Siti Khairunnisa , Hamzah Baharuddin , Mulyadi Rosady
Published: August 2023

Gorontalo City is characterized by a tropical climate, where thermal comfort is a crucial component to achieve, particularly for educational activities aimed at students. The thermal comfort is affected by various factors, namely building design, internal, and external factors. The university building represents a facility where face-to-face learning and teaching activities occur. The purpose of the current study is to analyze the perceived thermal comfort of students during classroom activities with three different air conditioning (AC) settings (16, 22, and 27 oC) in theUniversitas Ichsan Gorontalo campus building. This research employed a quantitative descriptive method, comprising thermal measurements inside the classroom and questionnaire distribution to students to collect thermal sensation data. The research object was conducted in three separate classrooms during the time range of 08.00-15.00 Central Indonesia time. The results revealed that most students felt neutral and comfortable in the three different AC settings inside the classroom. Nevertheless, it should be noted that thermal comfort could be influenced by other factors, such as physical activity and clothing. Consequently, further research could be conducted by taking into consideration these factors and engaging the participation of teachers and staff to acquire a more comprehensive understanding of thermal comfort in the campus building.
Adaptive Vibration Control of Smart Structure Using Deep Reinforcement Learning
Authors: Honda Shinya , Imura Yuta , Sasaki Katsuhiko , Takeda Ryo
Published: August 2023

In this research, the authors developed an adaptive control method using deep reinforcement learning which is a kind of machine learning to suppress the vibration of smart structures. This method just requires information about the control response and input, and don’t require numerical models for the controlled object to design the controller. We experimented to verify the effectiveness of this method. In this experiment, a smart structure fabricated by an aluminum plate and a piezoelectric actuator was used as a controlled object. Three kinds of reinforcement learning algorithms are employed, Deep Q Network (DQN), Deep Deterministic Policy Gradient (DDPG), and Twin Delayed DDPG (TD3), and the control performance is compared. As a result, we succeeded in reducing the  norm of the frequency response to impulse disturbance by up to about 40 dB compared to the uncontrolled case. This demonstrates the applicability of the control method using deep reinforcement learning to adaptive vibration control.
Development of A Presence System for Students Using QR Code Based on Android Application
Authors: Mar'atuttahirah Mar'atuttahirah , Rafrin Mardhiyyah , Mahdaniar Mahdaniar , Maharani Putri Ayu
Published: August 2023

The Department of Information System at Institut Teknologi B.J. Habibie still physically records each student's attendance by having them sign a presence sheet for each course. Due to the ease with which fraudulent signatures can be used to manipulate the traditional system, there may be some issues. Additionally, manual presence recapitulation takes more time and could be less precise and effective. This research aims to develop a prototype of Android-based application of student presence system with QR Code technology in the Department of Information System, Institut Teknologi B.J. Habibie. Following the creation of the presence system prototype, ISO 25010 quality standards were used to evaluate the application. The criteria evaluated are functionality, usability, portability, performance efficiency, and security. The application’s functionality was tested by two system experts by using Guttman Scale and it gained 100% yes answer. The usability was tasted from 30 users rating the application usability through a survey using Likert Scale, it achieved the average percentage of positive answers is 91%. The performance efficiency was classified as grade A by GTmetrix testing site. Similarly, the security system tested by sslabs.com achieved grade A. Furthermore, the portability was tested by using 4 different web browsers for the web version and by installing the application on 4 different smartphones and they showed no errors. Based on the overall assessment result, the Android-based Student Presence System is feasible, efficient, suitable and secure.
Study Experimental the Effect of Normalizing Treatment and Galvanic Pack Carburizing Process on Mechanical Properties of Low Carbon Steel
Authors: Annisa Citra Wahyu , Renreng Ilyas , Arma Lukamnul Hakim , Pian William
Published: August 2023

Steel is the type of metal most often used in engineering. This study aimed to improve the mechanical properties of mild steel in terms of hardness, ductility, and other mechanical properties and to compare the hardness of carburized steel by galvanic treatment with non-galvanic carburizing of the steel. This research was carried out by varying the heat treatment process, namely carburizing with galvanic heat treatment and carburizing without galvanic, where the carburizing process uses activated carbon coconut shell charcoal with a weight percentage of 80% and 20% of K2CO3 (Potassium Carbonate) at a temperature of 9000C with a holding time of 60 minutes, 120 minutes and 180 minutes. The results obtained from this study indicate that the mechanical properties (hardness) of carbon steel increase at a temperature of 9000C with a holding time of 1 hour on the galvanic heating method with a better hardness value than the hardness of steel on the non-galvanic method. The hardness value obtained in the galvanic method is 94.06 HRB, while in the non-galvanic method, it is 76.4 HRB. And the pearlite phase is formed, increasing the hardness value on the surface of the specimen.
Equilibrium Control of Robot Arm Tip Mounted on a Transfer Coaxial Two-Wheel Robot
Authors: Yasui Toshiharu , Sasaki Minoru , Matsushita Kojiro , Muguro Joseph , Njeri Waweru , Mulembo Titus
Published: August 2023

Japan has continued to experience population decline which adversely affect working-age group (15-64 years). As a remedy to this social issue, advancements in robotics and human-machine cooperation is proposed to make up for the declining labor force. To this end, design of robots which can work in constrained (indoor) workspace is desirable. A coaxial two-wheeled robot with an appended robot arm aimed at transporting objects is proposed in this paper. The robot is designed with center of gravity below the axle to make it statically stable at rest. It is combined with a robot arm with two links, two degrees of freedom. The goal is to maintain equilibrium of the arm tip during motion with the robot-arm is inclined at 0-, 3-, and 120-degree. In this study, simulations to combine a stable coaxial two-wheel robot with the robot arm is performed to confirm the effectiveness of the designed LQ, and LQI controller. From the results, all the controllers are able to maintain the robot-arm tip at 0-degrees. For 120-degrees, LQI performs better than LQ controller in stabilizing the rotation speed of the wheels by 1.7 seconds. In the future, the proposed controller model will be incorporated in the actual robot to confirm the performance for object transportation.
STRATEGI PEMBANGUNAN CITRA MELALUI KONTEN PRODUK LOKAL TIKTOK PADA DCT AGENCY
Authors: Nurizki Akbar
Published: August 2023

DCT Agency is an agency with services that accommodate brand image creation for local products through TikTok by involving content creators. The demand for brand image creation for local products and the role of TikTok content creators create an urgency for research on the topic. This research uses qualitative methods through interview and observation on DCT Agency. Data on this research is based on corporate identity, corporate communication, corporate image & reputation, and competitive advantage as analysis units and analysed through data reduction, data display, and verification. The result for this research explains DCT Agency's branding strategy through local product content on TikTok by considering the right targets, content that fits the brand identity, and relationships with the audience.

Keywords: branding, DCT Agency, local product content, TikTok
Certain Serum Enzymes Study of P-Thalassaemia Major Among Mosul Population
Authors: H. SharafKh. , M.M. Al-Anzy , G. MustafN.
Published: August 2023

Ninety-seven blood samples of the P-thalassaemia major were collected from patients registered in Mosul thalassemic center (lbn Al-Ather pediatric hospital ) for the period 2001-2002, distributed in 52 males and 45 females aged 3.5-24.0 yrs old, and 87 blood samples of apparently healthy volunteers aged 3.5-24.0 yrs old too, distributed in 56 males and 31 females for the same aged and the period time . Hb cone., sGPT, sGOT, and ALP values were determined in addition to the age estimation for the two trails. Statistical analysis, show there were significant differences (p<0.05) within Hb cone. of the normal individuals aged 3.5-6.0 and 18.0-24.0 yrs old. The Hb means cone. of both P-thalassaemia major and normal (control) were directly proportional to the sGPT and sGOT. while the Hb mean cone. of the P-thalassaemia major only was directly proportional to the ALP. The sGPT (17.64 u/1), sGOT (13.99 u/1), and ALP (16.43 u/1) values of the P-thalassaemia major was higher than that values ( 4.74 u/1 , 10.95 u/1, and 4.65 u/1 respectively) of the normal individuals .
Induction of brain lesions experimentally by inoculation of Staphylococcus aureus subcutaneously in rabbits (A histological study)
Authors: H.I. Ayad,
Published: August 2023

Six adult rabbits of both sexes were used tostudy the effect of Staphylococcus aureus on the brain tissue. Animals were classified into two groups. Group(A) was the control and Group(B) was the treated. Group (A) was inoculated with 0.8ml saline solution subcutaneously, and group (B) was inoculated subcutaneously with 0.8m1 suspension of Staph.aureus .The inculation process was repeated again with group (B) after 15 day. After (15) days from the second inoculation, the all animals of both groups were sacrified. A brain specimens from the frontel, parietal and temporal lobes of both groups were taken, processed for histological technique, embedded in the paraffin wax, sectioned at (5) µm thickness and stained by the haematoxylin & eosin for examination by the light microscopy. The brain tissues of group B, demonstrated the histopathological changes of the whole sites of the brain lobes, included, focal necrosis of the nerve cells, demyelination of the nerve fibers and gliosis. This effect may reflect the efficacy of the bacteria or its toxin or many both on the brain tissues.
Embryo toxicity of pefloxacin in mice
Authors: H. Lateef Rafah
Published: August 2023

Fluoroquinolones are extremely useful agents and an important therapeutic advance. Each fluoroquinolones tends produce characteristic adverse effects. Different studies showed that there was evidence about adverse effects of some :fluoroquinolones as levofloxacin, alatrofloxacin, trovaflxacin and moxifloxacin on the pregnant experimental lab. Animals when they were administered higher than the maximum recommended human doses , the current study was conducted to highlight the effects of different dosages of pefloxacin on the pregnant mice .The study revealed that the litter size and weight of bi1th were unaffected at the recommended oral human doses. Also reflects that there were little effects on body weight gain of dams when the dose exceeds the maximum recommended human dosage. No teratogenic effects were observed even at high oral doses. This project needs further investigation using different lab. Animals with large sample size.
The Relation of Hyperlipidemia with IHD in young and middle age in Tikrit city
Authors: AI-Janabi Jasim , S. Abdulla Mohammed , S.AL-Hindi Aseel
Published: August 2023

Hyperlipidemia is a major risk factor of ischemic heart disease (IHD). Many studies have demonstrated a direct correlation between raised serum lipids levels and incidence of JHD and atherosclerosis in humans. One hindered fifty healthy control individuals (86 male and 64 females )and (150) patients suffering from previous IHD (84 males and 66 females) were involved in this study. The blood samples from these groups were analyzed for serum total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein .All control individuals have a normal fasting blood glucose, normal resting electrocardiograph, blood pressure and serum lipids. The results revealed highest frequency of IHD in males (29.76%) and females (25.76%) among the age group (50-59) years. Also it showed that about (25%) of males and (24.24%) of fomales who were suffering from IHD were below 40 years.
Idiopathic epiretinal membranes removal with the foveal-sparing internal limiting membrane peeling
Authors:   Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation, Kolesnik A.I. , Kolesnik S.V. ,   Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation, Avakyan F.A. ,   Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation, Shpak A.A. ,   Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation, Pismenskaya V.A. ,   Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation, Zhuravlev A.S. ,   Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation
Published: August 2023

Introduction. The epiretinal membrane (ERM) is a connective tissue structure on the surface of the retina, formed as a result of proliferative and dystrophic processes in the inner layers of the retina and the cortical layers of the vitreous body. ERM has contractile properties and could cause tangential tractions, retinal folding and edema. To ensure the maximum preservation of visual functions, a method of ERM removal with the preservation of foveal inner limiting membrane (ILM) is proposed. Purpose. To present results of a new approach for ERM removal with preservation of foveal ILM on a series of clinical cases. Material and methods. The study included 3 patients with a diagnosis of ERM, with the complaints of metamorphopsia of less than 8 months. In addition to the standard ophthalmological examination, patients underwent optical coherence tomography (CirrusHD-OCT 5000; Carl Zeiss Meditec) and microperimetry (MAIA; CenterVue). Surgical intervention consisted in minimally invasive three-port vitrectomy with removal of ERM and ILM with preservation of foveal ILM. In the postoperative period, patients were examined at the time of 1, 3 and 6 months. Results. The analysis of microperimetric data showed that the degree of functional disorders corresponded to morphological changes: ectopia of the inner layers of the retina, deformation of its normal profile, a pronounced decrease in light sensitivity in the projection area of traction macular edema. In the postoperative period, the indicators of central light sensitivity improved gradually throughout the entire follow-up period. Conclusion. Thus, the proposed low-traumatic method of ERM removal with the preservation of foveal ILM, provides a stable anatomical and functional result, the restoration of both morphological and functional parameters. The data presented in this paper require confirmation in further comparative clinical trials. Key words: epiretinal membrane, surgical treatment, internal limiting membrane
A variant of using laser femtosecond facofragmentation without laser capsulotomy in the case of complicated cataract
Authors:   S. Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation, Gasanova K.S. , Panteleev E.N. ,   S. Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation, Shikhalieva E.A. ,   S. Fyodorov Eye Microsurger y Federal State Institution, Moscow, Russian Federation
Published: August 2023

Purpose. To evaluate the effectiveness of using femtosecond phacofragmentation without laser capsulotomy in cataract phacoemulsification with a relatively narrow pupil against the background of pseudoexfoliation syndrome in combination with grade I lens subluxation. Material and methods. The subject of the study was a case of complicated cataract in patient Ya., 74 years old, with complaints of decreased vision in the right eye. Standard preoperative and postoperative examinations were performed. The patient underwent surgery using a phacoemulsifier (CenturionVisionSystem, Alcon, USA) with preliminary laser femtosecond support (Catalys TM Precision Laser System-Johnson&Johnson Vision). A three-part IOL AcrySof MA60AC (Alcon, USA) with an optical power of 22.0 diopters was implanted. The peculiarity of the operation was that at the stage of laser femtosecond support, only phacofragmentation was performed without capsulotomy. Result. In this case, only phacofragmentation was performed without the formation of capsulorhexis with laser femtosecond support of phacoemulsification against the background of a rigid, relatively narrow pupil, which made it possible to safely use the usual methods of mechanical pupil dilation followed by manual performance of capsulorhexis of the optimal diameter. On the 2nd day after the operation, visual acuity without correction was 0.5, with a correction of –0.75 diopters – 0.7. The result of surgical treatment in this case indicates that a separate use of femtosecond laser fragmentation of the lens without anterior capsulotomy is possible. In this case, it was applied taking into account the combined pathology: pseudoexfoliation syndrome, lens subluxation, relatively narrow pupil and the objective need to use the Malyugin ring, the planned method of fixing the IOL. The preserved anterior capsule made it possible to perform standard implantation of the Malyugin ring without any special features, followed by capsulorhexis of the optimal diameter. Conclusion. This example demonstrates the possibility of safely and effectively performing phacofragmentation without capsulorhexis at the stage of laser femtosecond support during cataract phacoemulsification, when the pupil diameter does not allow programming the optimal capsulorhexis size. Key words: ciliocapsular fixation, intraocular lens, pseudoexfoliation syndrome, femtosecond laser
Intraoperative peripheral capsulotomy with cilio-capsular fixation: yes or no?
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Gasanova K.S. , Panteleev E.N. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Shikhalieva E.A. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Taevere M.Р. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation
Published: August 2023

Purpose. To obtain clinical confirmation of the need for intraoperative peripheral capsulotomy with cilio-capsular fixation. Material and methods. Clinical results of phacoemulsification of complicated cataract with femtosecond laser accompaniment against the background of pseudoexfoliation syndrome, grade I subluxation in a 65-year-old patient in the early postoperative period.In addition to standard examination methods, optical coherence tomography of the anterior segment of the eye was used. During the operation, cilio-capsular fixation of a three-part IOL was used without peripheral capsulotomy of the anterior capsule. In the early postoperative period, due to the developed capsular block, YAG laser dissection of the posterior lens capsule was used. Results. On the 3rd day after the operation, the maximum corrected visual acuity increased and amounted to 0.7, IOP – 12 mm Hg. Art.; before surgery – 0.3 and 22 mm Hg, respectively. According to optical coherence tomography after YAG laser discission, a sufficient decrease in the depth of the retrooptic space was determined, which indicates the absence of signs of a capsular block. Conclusion. During the study, it was found that in the absence of communication between the capsular bag with the anterior chamber, a capsular block is formed during cilio-capsular fixation. This necessitates intraoperative peripheral capsulotomy. Key words: capsular block, capsulotomy, capsular-ciliary fixation, three-part intraocular lens, pseudoexfoliative syndrome
ESPEN PRACTICAL GUIDELINE: CLINICAL NUTRITION IN CANCER
Authors: Muscaritoli Maurizio , Arends Jann , Bachmann Patrick , Baracos Vickie , Barthelemy Nicole , Bertz Hartmut , Bozzetti Federico , Hutterer Elisabeth , Isenring Elizabeth , Kaasa Stein
Published: August 2023

Довідкова інформація. Ці практичні настанови засновані на сучасних наукових настановах ESPEN з харчування онкологічних пацієнтів.

Методи. Для спрощення використання у клінічній практиці настанови ESPEN були скорочені та переведені в блок-схеми. Практичні настанови призначені для всіх фахівців, зокрема лікарів, дієтологів, нутриціологів і медичних сестер, які працюють з онкологічними пацієнтами.

Результати. В цілому представлено 43 рекомендації з короткими коментарями щодо лікування нутритивних і мета- болічних розладів у пацієнтів з онкологічними захворюваннями. Рекомендаціям, що надаються у зв’язку із захво- рюванням, передують загальні рекомендації з оцінки нутритивного статусу онкологічних хворих.

Висновок. Ця практична настанова надає рекомендації медичним працівникам, які беруть участь у лікуванні онко- логічних хворих, для забезпечення оптимального харчування.
Predictori ai evoluţiei clinice a schizofreniei
Authors: Crişan Cătălina-Angela , Pop Răzvan
Published: August 2023

Introduction. Schizophrenia is a serious disorder that influences all aspects of the patients’ life. The most important goals in schizophrenia are remission, recovery, and improving psychosocial functioning and quality of life. Unfortunately, there are important barriers to achieving optimal long-term outcomes in this disease due to patient-related factors and treatment-related factors. Lack of insight is considered the main reason for partial/non-adherence and, therefore, for the long-term outcome. 
Aim. The aim of this study was to identify the predictive factors involved in long-term schizophrenia, and especially the role of the awareness of illness. 
Materials and method. Eighty patients (44 males and 36 females) recruited from the First and Second Psychiatric Clinic from Cluj-Napoca, diagnosed according to ICD-10 criteria with schizophrenia, participated in this study. A semi-structured interview collected the demographical data. Psychotic symptoms were evaluated using Positive and Negative Syndrome Scale (PANSS), severity of the disease using Clinical Global Impression (CGI) and insight using the Scale for the Assessment of Unawareness of Mental Disorder (SUMD), the Schedule for Assessment of Insight-Expanded version (SAI-E) and Beck Cognitive Insight Scale (BCIS). 
Results. Our results showed that, among potential predictors of psychotic symptoms change measured in this research, those significantly correlated with changes are the level of insight measured with SUMD scale (r=-0.41; p<0.01), presence of family history (r=0.24; p<0.05), and belonging to urban areas (r=0.23; p<0.05). The level of insight, as one predictor, with PANSS initially controlled, explained 16% of variance of improving psychotic symptoms during hospitalization. Also, patients from urban areas seem to have a slight tendency towards higher magnitudes of the changes (low correlation, but statistically significant). Again, the square of the correlation obtained (coefficient of determination) indicates that urban membership explaines 5% of variance when symptoms improve. Also, it seems that the family history is positively associated with the magnitude of symptoms’ change, but the level of this relationship is also reduced. 
Conclusions. The awareness of illness is one of the predictive factors for long-term schizophrenia, and the best predictive model of disease progression is composed of variables SUMD total and PANSS total on admission.
Episod maniacal indus prin corticoterapie postalblaţie de meningiom spinal. Rolul realităţii virtuale în psihoterapia anxietăţii postoperatorii
Authors: Găină Marcel-Alexandru , Botezatu Ion-Emil , Petruţ Florin-Anton , Ştefănescu Bogdan‑Victor , Găină Alexandra-Maria , Galinescu Ilinca , Ştefănescu Cristinel
Published: August 2023

Corticosteroids have been linked to various neuropsychiatric adverse effects, including mood disorders. This case study describes a post-surgical manic episode (spinal meningioma ablation D11-D12) in a 57-year-old female patient on corticosteroids. This presentation aims to highlight corticosteroids’ potential psychiatric adverse effects and to emphasize the importance of recognizing and treating such complications. In this case, the management strategy involved discontinuing corticosteroids, initiating mood-stabilizing medications, and closely monitoring the symptoms. A mood stabilizer and a second-generation antipsychotic were administered to the patient to treat transient manic symptoms and prevent relapse. After discontinuing corticosteroids and beginning therapy with mood stabilizers, the patient’s bipolar symptoms improved. Psychoeducation and therapeutic support were provided to aid the patient in managing acute symptoms and encourage adherence to the treatment plan. As anxiety persisted after manic symptoms were controlled, the case management involved a psychotherapy technique facilitated by virtual reality. Relaxation breathing techniques were emulated through a virtual reality Oculus Quest 2 headset, improving patient-physician trust, subjectively relieving correlated anxiety, and ensuring therapeutic compliance during the admission and at home. Healthcare professionals must be vigilant to identify and effectively treat these complications of steroid anti-inflammatory medication. Immediate cessation of corticosteroids, the initiation of mood stabilizers and psychoeducation are essential for managing these cases. By presenting this case report, we hope to increase healthcare professionals’ awareness on the psychiatric consequences of corticosteroid use, the necessity of a multidisciplinary therapeutic approach, and the role of add-on virtual reality as integrated, personalized patient care to alleviate anxiety.
Separation of CO2 adsorption and H2 dissociation site in Co and In doped ZrO2 catalyst enhances methanol selectivity in CO2 hydrogenation
Authors: Dostagir Nazmul Hasan MD , Tomuschat Carlo Robert , Fukuoka Atsushi , Shrotri Abhijit
Published: August 2023

CO2 hydrogenation to methanol over mixed oxide catalysts is hindered by the poisoning effect of strongly adsorbed CO2 and formate species, which limits their H2 dissociation ability. Addition of noble metals to mixed oxides is a common practice to promote H2 dissociation but it inadvertently reduces methanol selectivity by simultaneously promoting CO formation. Herein, we show an alternative approach of doping Co in ZrO2 to create a separate site for adsorption of CO2 and counter the poisoning effect. We synthesized a ternary oxide of Co and In doped ZrO2 (Co-In-ZrO2), which showed higher methanol productivity and selectivity (65%) as compared to individual binary oxides of Co-ZrO2 and In-ZrO2 (29% and 44%). Detailed analysis showed that Co site was responsible for CO2 and formate adsorption while neighboring In atom was responsible for H2 dissociation to promote the hydrogenation of adsorbed CO2 to methanol over Co site. The cooperative effect reduced the activation energy for methanol formation to 80 kJ mol-1 over Co-In-ZrO2 in comparison to 139 and 116 kJ mol-1 over binary oxides. Moreover, CO formation was also suppressed leading to increased methanol selectivity. This cooperative effect was not unique to Co-In system but was also be extended to Co-Zn and Co-Ga doped ZrO2 catalysts. This work presents a different approach of designing mixed oxide catalysts for CO2 hydrogenation based on preferential adsorption of substrates and intermediates instead of promoting H2 dissociation.
Disclosing the interfacial electrolyte structure at Na-insertion electrode materials: origins of desolvation phenomenon
Authors: Goloviznina Kateryna , Bendadesse Ezzoubair , Sel Ozlem , Tarascon Jean-Marie , Salanne Mathieu
Published: August 2023

Among a variety of promising cathode materials for Na-ion batteries, polyanionic Na-insertion compounds are among the preferred choice due to known fast sodium transfer through the ion channels along their framework structures. The most interesting representatives are Na3V2(PO4)3 (NVP) and Na3V2(PO4)2F3 (NVPF), which display large Na+ diffusion coefficients and high voltage plateaux (up to 4.2V for NVPF). While the diffusion in the solid material is well-known to be the rate-limiting step during charging, already being thoroughly discussed in the literature, liquid-state transport of sodium ions towards the electrode was recently shown to be important due to complex ion desolvation effects at the interface. In order to fill the blanks in the description of the electrode/electrolyte interface in Na-ion batteries, we performed a molecular dynamics study of the local nanostructure of a series of carbonate-based sodium electrolytes at the NVP and the NVPF interfaces along with the careful examination of the desolvation phenomenon. We show that the tightness of solvent packing at the electrode surface is a major factor determining the height of the free energy barrier associated with desolvation, which explains the differences between the NVP and the NVPF structures. To rationalize and emphasize the remarkable properties of this family of cathode materials, a complementary comparative analysis of the same electrolyte systems at the carbon electrode interface was also performed.
Bioorthogonal Photocatalytic Profiling of Mitochondrial Proteomes from Primary Living Samples
Authors: Liu Ziqi , Guo Fuhu , Zhu Yufan , Qin Shengnan , Hou Yuchen , Lin Feng , Guo Haotian , Chen Peng , Fan Xinyuan
Published: August 2023

In situ profiling of subcellular proteomic networks in primary and living systems, such as primary cells derived from native tissues or clinic samples, is crucial for the understanding of life processes and diseases, yet challenging for the current proximity labeling methods (e.g., BioID, APEX) due to their necessity of genetic engineering. Here we report CAT-S, a new-generation bioorthogonal photocatalytic chemistry-enabled proximity labeling method, that extends proximity labeling to a wide range of primary living samples for in situ profiling of subcellular proteomes. Powered by the newly introduced thioQM labeling warhead and targeted bioorthogonal photocatalytic decaging chemistry, CAT-S enables in situ labeling of mitochondrial proteins in living cells with high efficiency and specificity. We applied CAT-S to distinct cell cultures, mouse tissues (kidney and spleen) as well as primary T cells from human blood, portraying the mitochondrial proteomic characteristics for various primary living samples, and unveiled a set of hidden mitochondrial proteins in human proteome. Furthermore, CAT-S allows quantitative analysis of the in situ proteomic perturbations on dysfunctional tissue samples, exampled by the comparative proteomics of diabetic mouse kidneys, and revealed the alterations of lipid metabolism machinery that drive the disease progression. Given the unique advantages of non-genetic operation, generality, efficiency as well as high spatiotemporal resolution, we envision that CAT-S may open new avenues as a proximity labeling strategy for in situ investigation of the native-state subcellular proteomic landscape of primary living samples that are otherwise inaccessible, promoting our understanding of the molecular mechanisms underlying biological and pathological processes.
Current state of open source force fields in protein-ligand binding affinity predictions
Authors: Hahn David F. , Gapsys Vytautas , de Groot Bert L. , Mobley David L. , Tresadern Gary J.
Published: August 2023

In drug discovery, the in-silico prediction of binding affinity is one of the major means to prioritize compounds for synthesis. Alchemical relative binding free energy (RBFE) calculations based on molecular dynamics (MD) simulations is nowadays a popular approach for accurate affinity ranking of compounds. MD simulations rely on empirical force field parameters, which strongly influence the accuracy of the predicted affinities. Here, we evaluate the ability of six different small-molecule force fields to predict experimental protein-ligand binding affinities in RBFE calculations on a set of 598 ligands and 22 protein targets. The public force fields OpenFF Parsley and Sage, GAFF and CGenFF show comparable accuracy, while OPLS3e is significantly more accurate. However, a Consensus approach using Sage, GAFF and CGenFF leads to accuracies comparable to OPLS3e. While Parsley and Sage are performing comparable based on aggregated statistics across the whole dataset, there are differences in terms of outliers. Analysis of the force field reveals that improved parameters lead to significant improvement in the accuracy of affinity predictions on subsets of the dataset involving those parameters. Lower accuracy cannot only be attributed to the force field parameters, but is also dependent of input preparation, and sampling convergence of the calculations. Especially large perturbations and non-converged simulations lead to less accurate predictions. The input structures, Gromacs force field files as well as the analysis python notebooks are available on github.
Structural Characterization and Ligand-Induced Conformational Changes of SenB, a Se-Glycosyltransferase Involved in Selenoneine Biosynthesis
Authors: Ireland Kendra , Kayrouz Chase , Huang Jonathan , Seyedsayamdost Mohammad , Davis Katherine
Published: August 2023

Selenium (Se) is an essential micronutrient that is found naturally in proteins, nucleic acids, and natural products. Unlike selenoproteins and selenonucleic acids, little is known about the structures of the biosynthetic enzymes that incorporate Se into small molecules. Here, we report the X-ray crystal structure of SenB, the first known Se-glycosyltransferase that was recently found to be involved in the biosynthesis of the Se-containing metabolite selenoneine. SenB catalyzes C–Se bond formation using selenophosphate and an activated uridine diphosphate sugar as a Se and glycosyl donor, respectively, making it the first known selenosugar synthase and only one of four bona fide C–Se bond-forming enzymes discovered to date. Our crystal structure, determined to 2.25 Å resolution, reveals that SenB is a type B glycosyltransferase, displaying the prototypical fold with two globular Rossmann-like domains and a catalytic interdomain cleft. By employing complementary structural biology techniques, we find that SenB undergoes both local and global substrate-induced conformational changes, demonstrating a significant increase in α-helicity and a transition to a more compact conformation. Our results provide the first structure of SenB and set the stage for further biochemical characterization in the future.
Facet Engineering for Manipulated Photoluminescence Blinking from Perovskite Nanocrystals
Authors: Ghosh Subhadip , Panda Mrinalkanti , Acharjee Debopam , Mahato Asit Baran
Published: August 2023

Photoluminescence (PL) blinking of nanoparticles, while detrimental for their optoelectronic and imaging applications, can be beneficial for next-generation displays, especially when blinking is precisely controlled by reversible electron/hole injection from an external source. Efforts have been made toward forming a definite charged state to understand trion-induced PL-blinking by electrochemical charging of nanoparticles, which may lead to greater control over PL-blinking. A key parameter deciding the success of controllable PL-blinking from nanoparticles is their affinities towards photo-oxidation and/or photo-reduction. This work shows that facet engineering renders perovskite nanocrystals (PNCs) with distinct blinking properties based on their number of facets. Interestingly, the off-duration (τ_off) in the PL intensity time-trace and the fraction time spent in the off-state of a surface-immobilized PNC enhance as the number of facets increases from six (cube-PNC) to twelve (dodecahedron-PNC) and, to twenty-six (rhombicuboctahedron-PNC). Our observation suggests a greater affinity for photo-charging of extra faceted PNCs.
MODERN LEARNING IMPROVEMENTS SUPPORTED BY IT SOLUTIONS – SLIDO CASE STUDY FOR BETTER ENGAGEMENT
Authors: STOJAKOVIĆ Dušan
Published: August 2023

According to a study published by UNESCO at the beginning of the coronavirus pandemic, about 84% of the world's population studying some of the educational programs (including formal education through primary, secondary and higher education, and university undergraduate and postgraduate studies) is affected by prevention and social distances. Experts estimate that such disability and absenteeism will cause a significant and noticeable lack of theoretical knowledge and practical skills at the global level for several generations, the study of which was lacking in the process of switching from physical to online teaching and digital study of the material. for studying in the physical environment of a classroom, amphitheatre, laboratory or similar educational facilities.One of the ways to partially alleviate this process of not studying the entire prescribed material and accredited curricula on time relies on more intensive application of IT technologies, innovations and solutions, with a special focus on increasing the degree of student involvement in active learning. One of such IT solutions is SLIDO, an online software, primarily aimed at use for business purposes but certainly and unstoppably finding its way to improve education. This paper aims to explore potentials of increasing students’ engagement through IT solutions like SLIDO.
DIGITAL EURO AS NEXT EVOLUTION OF THE EUROPEAN CURRENCY
Authors: UNGUREANU DRAGOS ADRIAN
Published: August 2023

Digitalisation has spread to every corner of our lives and transformed how we pay. In this new era, a digital euro would guarantee that citizens in the euro area can maintain costless access to a simple, universally accepted, safe and trusted means of payment. A digital euro would not replace cash, but rather complement it. The Eurosystem will continue to ensure the access to cash across the euro area. A digital euro would give an additional choice about how to pay and make it easier to do so, contributing to accessibility and inclusion. It would support the digitalisation of the European economy and actively encourage innovation in retail payments.
Religious Liberty and Atheism: The Case of Richard Dawkins
Authors: Kristiatmo Thomas
Published: August 2023

Through the Second Vatican Council, the Catholic Church asserts the import of religious liberty for every individual and believes that one is entitled to live out one’s faith. Thus, through Dignitatis Humanae, the Church has revealed her intention to create inter-religion dialogues and to encourage respect for the positive values of different religions. This raises a question as to whether such dialogues and respect as voiced in Dignitatis Humanae are applicable when it comes to the issue of atheism, a pressing issue faced by the Church today. This article explores the engagement of such document with atheism. Since atheism covers various views coming from a number of authors, this current article focuses only on the atheism as promoted by Richard Dawkins. Building his atheism upon science, Dawkins’ views  are worthy of our attention in today’s world, which is characterised by unending scientific revolutions.
Professional Bottlenecks and Targeted Suggestions for Young Teachers in Vocational Colleges
Authors: Wang Shang , Ma Jinru , Zheng Shuo
Published: August 2023

This paper analyzes the professional bottlenecks limiting the career development of young teachers in vocational colleges, including insufficient teaching skills, limited research capacity, and restricted professional development and career progression. Targeted recommendations involve fostering young teachers’ teaching skills and research capabilities through mentorship, training, research participation and skills competition guidance. Addressing these bottlenecks effectively develops young teachers’ competencies, contributing innovative ideas and practices to improve vocational education quality, cementing their role as the next generation of vocational educators.
New Advances in Social Cognitive Neuroscience
Authors: Li Xue
Published: August 2023

Social cognitive neuroscience, as an important branch of the field of neuroscience, studies the cognitive, emotional and interactive processes of individuals in social environments. In recent years, with the continuous development of neuroscience, social cognitive research has been progressing steadily. This paper discusses the latest research progress in the field of social cognitive neuroscience from the perspective of neuroscience, covering the mechanism of emotional disorders and cognitive decision making, and brain imaging of social cognitive neuroscience. These advances not only deepen our understanding of social cognition, but also provide new ideas for the intervention and treatment of social cognitive disorders.