bluuebunny/crossref_metadata_2025 huggingface dataset:
Electron and Positron Scattering from Precious Metal Atoms in the eV to MeV Energy Range
Authors: Jakubassa-Amundsen Doris H. , Haque Abul Kalam Fazlul , Haque Md. Monirul , Billah Md. Masum , Basak Arun Kumar , Saha Bidhan Chandra , Uddin Md. Alfaz
Published: August 2022

This article reports on the scattering of unpolarized and spin polarized electrons and positrons from 28Ni58,29Cu63,46Pd108, and 78Pt196, covering light to heavy precious metal targets. To cover the wide energy domain of 1 eV ≤Ei≤300 MeV, Dirac partial-wave phase-shift analysis is employed, using a complex optical potential for Ei≤1 MeV and a potential derived from the nuclear charge distribution for Ei>1 MeV. Results are presented for the differential and integral cross-sections, including elastic, momentum transfer, and viscosity cross-sections. In addition, the inelastic, ionization, and total (elastic + inelastic) cross-section results are provided, together with mean free path estimates. Moreover, the polarization correlations S,T, and U, which are sensitive to phase-dependent interference effects, are considered. Scaling laws with respect to collision energy, scattering angle, and nuclear charge number at ultrahigh energies are derived using the equivalence between elastic scattering and tip bremsstrahlung emission. In addition, a systematic analysis of the critical minima in the differential cross-section and the corresponding total polarization points in the Sherman function S is carried out. A comparison with existing experimental data and other theoretical findings is made in order to test the merit of the present approach in explaining details of the measurements.
A Novel Algorithmic Forex Trade and Trend Analysis Framework Based on Deep Predictive Coding Network Optimized with Reptile Search Algorithm
Authors: Dash Swaty , Sahu Pradip Kumar , Mishra Debahuti , Mallick Pradeep Kumar , Sharma Bharti , Zymbler Mikhail , Kumar Sachin
Published: August 2022

This paper proposed a short-term two-stage hybrid algorithmic framework for trade and trend analysis of the Forex market by augmenting the currency pair datasets with transformed attributes using a few technical indicators and statistical measures. In the first phase, an optimized deep predictive coding network (DPCN) based on a meta-heuristic reptile search algorithm (RSA) inspired by the intelligent hunting activities of the crocodiles is exploited to develop this RSA-DPCN predictive model. The proposed model has been compared with optimized versions of extreme learning machine (ELM) and functional link artificial neural network (FLANN) with genetic algorithm (GA), particle swarm optimization (PSO), and differential evolution (DE) along with the RSA optimizers. The performance of this model has been evaluated and validated through several statistical tests. In the second phase, the up and down trends are analyzed using the Higher Highs Higher Lows, and Lower Highs Lower Lows (HHs/HLs and LHs/LLs) trend analysis tool. Further, the observed trends are compared with the actual trends observed on the exchange price of real datasets. This study shows that the proposed RSA-DPCN model accurately predicts the exchange price. At the same time, it provides a well-structured platform to discern the directions of the market trends and thereby guides in finding the entry and exit points of the Forex market.
Learning and Applying Cooperative Solutions: A Classroom Experiment on Transportation Games
Authors: Georgantzis Nikolaos , Gutiérrez-Hita Carlos , Sánchez-Soriano Joaquín
Published: August 2022

In a trade experiment, groups of students were taught how to bargain over a pie generated in a transportation game. Data collection and detailed group reports of the bargaining process allowed us to identify the type of bargaining followed and its correspondence with cooperative game theory concepts. Explicit coalitions were rather scarce (17%), although coalition stability was implied by 47.8% of the agreements. Efficiency was achieved in the vast majority (82%) of cases, whereas in 34.8% of the agreements, students used a lexicographic ordering of multiple solutions before choosing among them. Regarding the bargaining procedure, in 40% of the agreements, quantities traded were decided before profit sharing rules were negotiated, whereas in 16% of the cases they were simultaneously agreed upon. Our findings suggest that bargaining procedures often do not imply explicit coalitions. Moreover, efficiency can be achieved even in the absence of bargaining processes.
CARDIOSIM©: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support
Authors: De Lazzari Beatrice , Badagliacca Roberto , Filomena Domenico , Papa Silvia , Vizza Carmine Dario , Capoccia Massimo , De Lazzari Claudio
Published: August 2022

This review is devoted to presenting the history of the CARDIOSIM© software simulator platform, which was developed in Italy to simulate the human cardiovascular and respiratory systems. The first version of CARDIOSIM© was developed at the Institute of Biomedical Technologies of the National Research Council in Rome. The first platform version published in 1991 ran on a PC with a disk operating system (MS-DOS) and was developed using the Turbo Basic language. The latest version runs on PC with Microsoft Windows 10 operating system; it is implemented in Visual Basic and C++ languages. The platform has a modular structure consisting of seven different general sections, which can be assembled to reproduce the most important pathophysiological conditions. One or more zero-dimensional (0-D) modules have been implemented in the platform for each section. The different modules can be assembled to reproduce part or the whole circulation according to Starling’s law of the heart. Different mechanical ventilatory and circulatory devices have been implemented in the platform, including thoracic artificial lungs, ECMO, IABPs, pulsatile and continuous right and left ventricular assist devices, biventricular pacemakers and biventricular assist devices. CARDIOSIM© is used in clinical and educational environments.
A Decrease in the Staminode-Mediated Visitor Screening Mechanism in Response to Nectar Robbers Positively Affects Reproduction in Delphinium caeruleum Jacq. ex Camb. (Ranunculaceae)
Authors: Hou Qinzheng , Wang Taihong , Yang Guang , Shao Wenjuan , Min Wenrui , Zhong Yuqin
Published: August 2022

Nectar-robbing insects, which are frequently described as cheaters in plant–pollinator mutualisms, may affect plant reproductive fitness by obtaining nectar rewards without providing pollination services. The negative effects of nectar robbing on plant reproductive success have been widely reported, but the reasons for possible positive effects demand further investigation. The goal of the study was to evaluate the effects of nectar robbing on the reproductive success of Delphinium caeruleum. Two staminodes cover the stamens and pistils in the flowers of D. caeruleum, forming a “double door” type of structure that compels pollinators to physically manipulate the staminodes to access the sex organs. In order to explore whether the operative strength required to open the staminodes is affected by actions associated with nectar robbing, we set up five different treatment groups: no nectar robbing, natural nectar robbing, artificial nectar robbing, hole making, and nectar removal. A biological tension sensor was used to measure the operative strength required to open the staminodes in the flowers. We also assessed the effect of nectar robbing on the flower-visiting behavior of pollinators and the effect of nectar robbing on reproductive fitness by the flower. The results showed that the operative strength needed to open staminodes was reduced by nectar robbers but not by artificial nectar robbing, hole making, or nectar removal. The flowers’ continuous visitation rate and visitation frequency by pollinators decreased significantly in robbed flowers. Both the pollen export and pollen deposition in naturally robbed flowers were significantly higher than those in nonrobbed flowers. Our results demonstrate that nectar robbers play an indirect positive role in the reproductive fitness of D. caeruleum flowers by reducing the operative strength of staminodes to promote pollen transfer. The reduction in operative strength of staminodes might be an adaptive mechanism that responds to nectar robbing.
Bibliometric Analysis of Studies on Whole Body Electromyostimulation
Authors: Rodrigues-Santana Luiz , Adsuar José Carmelo , Denche-Zamorano Ángel , Vega-Muñoz Alejandro , Salazar-Sepúlveda Guido , Contreras-Barraza Nicolás , Galán-Arroyo Carmen , Louro Hugo
Published: August 2022

Whole Body Electromyostimulation [WB-EMS] is a training methodology that applies electrostimulation in the main muscle groups of the human body superimposed with active training exercises. This study aims to carry out a bibliometric analysis on WB-EMS to provide an overview of the state of research and provide new insights for research in the field. Method: One hundred and two citations extracted were examined using a bibliometric approach based on data stored in the Web of Science Core Collection, applying traditional bibliometric laws, and using VOSviewer and excel for data and metadata processing. Results: Among the results, this study points out that Germany is the country that produces more scientific knowledge on WB-EMS. Wolfgang Kemmler is the most relevant author in this field. Moreover, Frontier of Physiology is the journal where the authors publish the most. Conclusion: Research on WB-EMS has been growing in recent years. German and Spanish researchers lead two clusters where most studies and collaborations in this field are carried out. These findings will provide a better understanding of the state of WB-EMS research and may guide the emergence of new lines of investigation and research ideas.
Downregulating Mitochondrial DNA Polymerase γ in the Muscle Stimulated Autophagy, Apoptosis, and Muscle Aging-Related Phenotypes in Drosophila Adults
Authors: Ozaki Mika , Le Tuan Dat , Inoue Yoshihiro H.
Published: August 2022

Reactive oxygen species, generated as by-products of mitochondrial electron transport, can induce damage to mitochondrial DNA (mtDNA) and proteins. Here, we investigated whether the moderate accumulation of mtDNA damage in adult muscles resulted in accelerated aging-related phenotypes in Drosophila. DNA polymerase γ (Polγ) is the sole mitochondrial DNA polymerase. The muscle-specific silencing of the genes encoding the polymerase subunits resulted in the partial accumulation of mtDNA with oxidative damage and a reduction in the mtDNA copy number. This subsequently resulted in the production of abnormal mitochondria with reduced membrane potential and, consequently, a partially reduced ATP quantity in the adult muscle. Immunostaining indicated a moderate increase in autophagy and mitophagy in adults with RNA interference of Polγ (PolγRNAi) muscle cells with abnormal mitochondria. In adult muscles showing continuous silencing of Polγ, malformation of both myofibrils and mitochondria was frequently observed. This was associated with the partially enhanced activation of pro-apoptotic caspases in the muscle. Adults with muscle-specific PolγRNAi exhibited a shortened lifespan, accelerated age-dependent impairment of locomotor activity, and disturbed circadian rhythms. Our findings in this Drosophila model contribute to understanding how the accumulation of mtDNA damage results in impaired mitochondrial activity and how this contributes to muscle aging.
Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant
Authors: Fernández-de-las-Peñas César , Cancela-Cilleruelo Ignacio , Moro-López-Menchero Paloma , Rodríguez-Jiménez Jorge , Gómez-Mayordomo Víctor , Torres-Macho Juan , Pellicer-Valero Oscar J. , Martín-Guerrero José D. , Hernández-Barrera Valentín , Arendt-Nielsen Lars
Published: August 2022

We compared the prevalence of musculoskeletal post-COVID pain between previously hospitalized COVID-19 survivors infected with the historical, Alpha or Delta SARS-CoV-2 variant. Data about musculoskeletal post-COVID pain were systematically collected through a telephone interview involving 201 patients who had survived the historical variant, 211 who had survived the Alpha variant and 202 who had survived the Delta variant six months after hospital discharge. Participants were recruited from non-vaccinated individuals hospitalized due to SARS-CoV-2 infection in one hospital of Madrid (Spain) during three different waves of the pandemic (historical, Alpha or Delta variant). Hospitalization and clinical data were collected from hospital medical records. In addition, anxiety/depressive levels and sleep quality were also assessed. The prevalence of musculoskeletal post-COVID pain was higher (p = 0.003) in patients infected with the historical variant (47.7%) than in those infected with the Alpha (38.3%) or Delta (41%) variants. A significantly (p = 0.002) higher proportion of individuals infected with the historical variant reported generalized pain (20.5%) when compared with those infected with the other variants. The prevalence of new-onset post-COVID musculoskeletal pain reached 80.1%, 75.2% and 79.5% of patients infected with the historical, Alpha or Delta variants, respectively. No specific risk factors for developing post-COVID pain were identified depending on the SARS-CoV-2 variant. In conclusion, this study found that musculoskeletal post-COVID pain is highly prevalent in COVID-19 survivors six months after hospital discharge, with the highest prevalence and most generalized pain symptoms in individuals infected with the historical variant. Approximately 50% developed “de novo” post-COVID musculoskeletal pain symptoms.
Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study
Authors: Sarton Benjamine , Grare Marion , Vardon-Bounes Fanny , Gaubert Anna , Silva Stein , Crognier Laure , Riu Béatrice , Seguin Thierry , Georges Bernard , Minville Vincent , Ruiz Stéphanie
Published: August 2022

Considering virus-related and drug-induced immunocompromised status of critically ill COVID-19 patients, we hypothesize that these patients would more frequently develop ventilator-associated pneumonia (VAP) than patients with ARDS from other viral causes. We conducted a retrospective observational study in two intensive care units (ICUs) from France, between 2017 and 2020. We compared bacterial co-infection at ICU admission and throughout the disease course of two retrospective longitudinally sampled groups of critically ill patients, who were admitted to ICU for either H1N1 or SARS-CoV-2 respiratory infection and depicted moderate-to-severe ARDS criteria upon admission. Sixty patients in the H1N1 group and 65 in the COVID-19 group were included in the study. Bacterial co-infection at the endotracheal intubation time was diagnosed in 33% of H1N1 and 16% COVID-19 patients (p = 0.08). The VAP incidence per 100 days of mechanical ventilation was 3.4 (2.2–5.2) in the H1N1 group and 7.2 (5.3–9.6) in the COVID-19 group (p < 0.004). The HR to develop VAP was of 2.33 (1.34–4.04) higher in the COVID-19 group (p = 0.002). Ten percent of H1N1 patients and 30% of the COVID-19 patients had a second episode of VAP (p = 0.013). COVID-19 patients have fewer bacterial co-infections upon admission, but the incidence of secondary infections increased faster in this group compared to H1N1 patients.
Does Childhood Obesity Trigger Neuroinflammation?
Authors: Zingale Valeria Domenica , D’Angiolini Simone , Chiricosta Luigi , Calcaterra Valeria , Selvaggio Giorgio Giuseppe Orlando , Zuccotti Gianvincenzo , Destro Francesca , Pelizzo Gloria , Mazzon Emanuela
Published: August 2022

Childhood obesity is constantly increasing around the world, and it has become a major public health issue. Considerable evidence indicates that overweight and obesity are important risk factors for the development of comorbidities such as cognitive decline, neuroinflammation and neurodegenerative diseases. It is known that during obesity, adipose tissue undergoes immune, metabolic and functional changes which could induce a neuroinflammatory response of the central nervous system (CNS). In this context, to inspect if obesity can start to trigger the neuroinflammation from a pediatric age, we surgically collected and analyzed adipose tissue from the periumbilical area of three obese children (AT-OB) and two normal-weight children (AT-Ctrl). We considered the transcriptomic profile of our samples to detect alterations in different biological processes that might be also involved in the inflammatory and neuroinflammatory response. Our results show alterations of lipid and fatty acids metabolism in AT-OB compared to the AT-Ctrl. We also observed an onset of inflammatory response in AT-OB. Interestingly, among the genes involved in neuroinflammation, GRN and SMO were upregulated, while IFNGR1 and SNCA were downregulated. Our study highlights that obesity may trigger inflammation and neuroinflammation from a pediatric age.
Microsurgical Management of Posterior Circulation Aneurysms: A Retrospective Study on Epidemiology, Outcomes, and Surgical Approaches
Authors: You Wanchun , Meng Jiahao , Yang Xingyu , Zhang Jie , Jiang Guannan , Yan Zeya , Gu Feng , Tao Xinyu , Chen Zhouqing , Wang Zhong , Chen Gang
Published: August 2022

Posterior circulation aneurysms have been regarded as the most challenging for endovascular coiling and microsurgical occlusion. The role of microsurgical treatment is gradually being overlooked and diminishing in the trend of endovascular treatment. As microsurgical occlusion of posterior circulation aneurysms is decreasing, we present our relevant experience to evaluate treatment options and surgical approaches. A retrospective study was conducted in the Department of Neurosurgery of the First Affiliated Hospital of Soochow University between 2016 and 2021. Patients with posterior circulation aneurysms treated by clipping, bypass, and trapping were enrolled and followed up for at least six months. We included 50 patients carrying 53 posterior circulation aneurysms, 43 of whom had aneurysm ruptures. The posterior cerebral artery and posterior inferior cerebellar artery were the most common aneurysm locations. Direct clipping was performed in 43 patients, while bypass and trapping was performed in six patients. The retrosigmoid, far-lateral, and midline or paramedian suboccipital approaches were performed for those aneurysms in the middle and lower thirds. Aneurysms in the upper third required the lateral supraorbital approach, pterional approach, subtemporal approach, and occipital craniotomy. The lateral supraorbital approach was utilized in seven patients for aneurysms above the posterior clinoid process. Thirty-four patients recovered well with modified Rankin score 0–3 at discharge. No patient experienced aneurysm recurrence during the mean follow-up period of 3.57 years. Microsurgery clipping and bypass should be considered in conjunction with endovascular treatment as a treatment option in posterior circulation aneurysms. The lateral supraorbital approach is a feasible, safe, and simple surgical approach for aneurysms above the posterior clinoid process.
The Number of Monthly Night Shift Days and Depression Were Associated with an Increased Risk of Excessive Daytime Sleepiness in Emergency Physicians in South Korea
Authors: Park Song Yi , Lee Hyung Min , Kim Jiyoung
Published: August 2022

This study aimed to report the prevalence and identify the factors associated with excessive daytime sleepiness (EDS) among emergency physicians in South Korea. We analyzed the Korean Emergency Physicians Survey data from 15 January to 26 February 2021. EDS was evaluated using the Epworth sleepiness scale, and a score of 11 or more indicated the presence of EDS. We conducted univariable and multivariable logistic regression analyses to verify the associated factors. A total of 1307 participants responded to the survey, and the response rate was 61.3%. Nine hundred fifty-four participants were included in the study. Two hundred ninety-three participants were classified as the EDS group, and six hundred sixty-one were classified as the non-EDS group. The prevalence of EDS was 30.7% (95% confidence interval (CI), 27.8–33.6%). Monthly night-shift days (odds ratio (OR) 1.106, 95% CI 1.028–1.191) and depression (OR 2.635, 95% CI 1.799–3.861) were significantly associated with an increased risk of EDS, and fair sleep quality (OR 0.560, 95% CI 0.318–0.985) was associated with a decreased risk of EDS. Almost one in three emergency physicians in South Korea suffer from daytime sleepiness. The number of monthly night-shift days and depression were associated with an increased risk of EDS.
Research on the Flutter Stability of Bridge Sections Based on an Empirical Formula of an Aerostatic Three-Component Coefficient
Authors: Gao Hui , Wang Feng , Guan Qinghai , Hou Huifang , Li Jiawu
Published: August 2022

In order to study the relationship between an aerostatic three-component coefficient (ATCC) and bridge flutter and to quickly evaluate the flutter performance of bridges, we proposed a method based on the empirical formula of the ATCC. The correlation between the flutter driving term and the critical flutter wind speed V of nine bridges (six types of girder sections) was analyzed, and its rationality was verified using wind tunnel test results. The results showed that the flutter stability of the X-term damping-driven type, i.e., the slotted box girder, was the best; the flutter stability of the X + D-term damping-driven type, i.e., the H-shape bridge deck, was the worst; the flutter stability of D-term damping-driven type was measured as being between these two values. The gray correlation analysis method was used to analyze the correlation between the ATCC and the critical flutter wind speed. As well as the relationship between the ATCC and aerodynamic damping, an empirical parameter, K, based on the ATCC, was proposed for use in determining the D-term damping-driven flutter. The flutter stability of three types of girder sections was analyzed using parameter K, and the results of the analysis were consistent with the wind tunnel test results. The results show that the ATCC obtained from the segmental model force test can be used to preliminarily realize the rapid comparison and selection of flutter aerodynamic measures for bridges.
The Use of SMAV Model for Computing Fragility Curves
Authors: Vacca Vitantonio , Occhipinti Giuseppe , Mori Federico , Spina Daniele
Published: August 2022

Among the buildings with strategic role for civil protection purposes part of them were built before the introduction of modern seismic codes. Aiming to guarantee their operability in case of seismic events, they have to be assessed and, hopefully, seismically upgraded. This aspect arises the necessity of reliable low computational demanding numerical models and probabilistic strategies that can be easily adopted in case of the assessment of conspicuous building stock. Part of the authors proposed and validated, in previous works, a low-demanding seismic model calibrated on ambient vibrations (SMAV) that is engaged in this paper for calculating fragility curves. On the base of dynamic and geometric properties, the SMAV model simulates the dynamic response of buildings. The herein proposed procedure adopts the SMAV model and takes into account the direction of seismic input in a probabilistic manner. The use of the ASI scale as an Intensity Measure parameter is discussed and the results are compared to those obtained with others IM scales. Although SMAV implements an equivalent linear procedure the results are compared with those obtained by more sophisticated FEM models and nonlinear dynamic analyses with a satisfactory agreement. Finally, two real case studies are presented. The fragility curves for both the case studies are calculated and discussed. The results encourage the authors to the use of fragility curves based on SMAV model. Additionally, the fragility curves can be easily implemented in seismic risk assessment procedures at urban or territorial scale and, consequently, the proposed procedure may represent a key aspect in the reduction of seismic risk and rationalization of investments for the seismic upgrading of strategic buildings.
Corrosion Damage Identification of Towering Steel Headframe Based on Parametric Modeling and Data Fusion
Authors: Zhang Rui , Chang Hongfei , Li Zhaowei , Song Xinyi , Yang Jianchao , Xia Junwu
Published: August 2022

The mine hoisting headframe is a typical towering truss structure, and its damage is complicated after long-term service, which affects the safety of the structure. To achieve rapid identification of corrosion damage on a towering steel headframe, the degradation law of headframe under different damage was analyzed via parametric modeling method and verified via field measurement. The results show that the influence range of element corrosion damage is localized, and a 50% corrosion rate of the bottom column will lead to a collapse risk of the headframe. After that, the single index method, of superimposed curvature mode difference and modal flexibility difference curvature, is used to identify corrosion damage of headframe column. The results indicate that the single index method is susceptible to interference in the undamaged position and leads to error identification. The improved multi-index data fusion damage identification method based on D-S evidence matrix is proposed, through which the multi-position damages in headframe structure can be identified accurately. Compared to the one-stage fusion method, the improved two-stage fusion method is more robust, with an increase of 42.9% in identification accuracy, and a reduction of 75% in misjudgment.
Evaluation of Inverted-Pendulum-with-Rigid-Legs Walking Locomotion Models for Civil Engineering Applications
Authors: Živanović Stana , Lin Bintian , Dang Hiep Vu , Zhang Sigong , Ćosić Mladen , Caprani Colin , Zhang Qingwen
Published: August 2022

Bipedal models for walkers, originally developed in the research field of biomechanics, have been identified as potential candidates for modelling pedestrians in structural engineering applications. These models provide insight into both the kinetics and kinematics of walking locomotion and are considered to have a significant potential to improve the vibration serviceability assessment of civil engineering structures. Despite this notion, the ability of the bipedal models to represent the key features of the walking gait and natural variability within the pedestrian population are still under-researched. This paper critically evaluates the performance of two bipedal models with rigid legs to realistically both reproduce key features of an individual pedestrian’s walking gait and represent a wide range of individuals. The evaluation is performed for walking on a rigid, rather than vibrating, structure due to the availability of experimental data and expectation that successful modelling on rigid surfaces is a necessary condition for progressing towards modelling on the vibrating structures. Ready-to-use equations are provided and the ability of the models to represent the kinematics and kinetics of individual pedestrians as well as the inter-subject variability typical of the human population is critically evaluated. It was found that the two models could generate realistic combinations of the gait parameters and their correlations, but are less successful in reproducing genuine kinetic and kinematics profiles.
Numerical Analysis of the Seismic Behavior of a Steel Beam-to-Concrete-Filled Steel Tubular Column Connection Using External Diaphragms
Authors: Ramírez Ortiz Cristhian , Gutierrez Amador Albio D. , Ramírez Duque Jose L.
Published: August 2022

The seismic behavior of a novel steel beam-to-concrete-filled steel tubular column connection with external diaphragms was evaluated numerically by using a model based on the finite element method. The model was validated against experimental results performed in previous work, which revealed that this type of connection is suitable for use in special moment frame structures located in areas of high seismic threat. The comparison included the hysteresis curve, plasticization mechanism, and plastic hinge location. Then, the model was used to study the behavior of the connection for a monotonic test. It was observed that the monotonic test can be used for the qualification of the connection, avoiding the excessive time required for the solution of the cyclic load test. In addition, two stages of simplifications were conducted in the model, showing satisfactory results and significant reductions in computational time. For the first stage, the lateral support beam was removed and replaced by a connection with an infinite lateral rigidity. Second, beam-type elements were implemented in the remote areas of the plastic hinge location. Finally, the simplified model was used in a parametric study that examined the behavior of the connection under four different European type I profiles. It was observed that all the profiles meet the requirements for seismic performance.
Calorimetric Markers for Detection and Monitoring of Multiple Myeloma
Authors: Krumova Sashka , Todinova Svetla , Taneva Stefka G.
Published: August 2022

This review summarizes data obtained thus far on the application of differential scanning calorimetry (DSC) for the analysis of blood sera from patients diagnosed with multiple myeloma (MM) with the secretion of the most common isotypes of monoclonal proteins (M-proteins), free light chains (FLC) and non-secretory MM, as well as Waldenström macroglobulinemia and the premalignant state monoclonal gammopathy of undetermined significance. The heterogeneous nature of MM is reflected in the thermal stability profiles of the blood serum proteome of MM patients found to depend on both the level and the isotype of the secreted M-proteins or FLC. Common calorimetric markers feature the vast majority of the different myeloma types, i.e., stabilization of the major serum proteins and decrease in the albumin/globulin heat capacity ratio. A unique calorimetric fingerprint of FLC molecules forming amorphous aggregates is the low-temperature transition centered at 57 °C for a calorimetric set of FLC MM and at 46–47 °C for a single FLC MM case for which larger aggregates were formed. The calorimetric assay proved particularly advantageous for non-secretory MM and is thus a suitable tool for monitoring such patients during treatment courses. Thus, DSC provides a promising blood-based approach as a complementary tool for MM detection and monitoring.
Performances of Functional and Anatomic Imaging Modalities in Succinate Dehydrogenase A-Related Metastatic Pheochromocytoma and Paraganglioma
Authors: Patel Mayank , Jha Abhishek , Ling Alexander , Chen Clara C. , Millo Corina , Kuo Mickey J. M. , Nazari Matthew A. , Talvacchio Sara , Charles Kailah , Miettinen Markku , Del Rivero Jaydira , Chen Alice P. , Nilubol Naris , Lin Frank I. , Civelek Ali Cahid , Taïeb David , Carrasquillo Jorge A. , Pacak Karel
Published: August 2022

The study identifies the importance of positron emission tomographic (PET) and anatomic imaging modalities and their individual performances in detecting succinate dehydrogenase A (SDHA)-related metastatic pheochromocytoma and paraganglioma (PPGL). The detection rates of PET modalities—68Ga-DOTATATE, 18F-FDG, and 18F-FDOPA—along with the combination of computed tomography (CT) and magnetic resonance imaging (MRI) are compared in a cohort of 11 patients with metastatic PPGL in the setting of a germline SDHA mutation. The imaging detection performances were evaluated at three levels: overall lesions, anatomic regions, and a patient-by-patient basis. 68Ga-DOTATATE PET demonstrated a lesion-based detection rate of 88.6% [95% confidence interval (CI), 84.3–92.5%], while 18F-FDG, 18F-FDOPA, and CT/MRI showed detection rates of 82.9% (CI, 78.0–87.1%), 39.8% (CI, 30.2–50.2%), and 58.2% (CI, 52.0–64.1%), respectively. The study found that 68Ga-DOTATATE best detects lesions in a subset of patients with SDHA-related metastatic PPGL. However, 18F-FDG did detect more lesions in the liver, mediastinum, and abdomen/pelvis anatomic regions, showing the importance of a combined approach using both PET modalities in evaluating SDHA-related PPGL.
A Novel Splice Variant of BCAS1 Inhibits β-Arrestin 2 to Promote the Proliferation and Migration of Glioblastoma Cells, and This Effect Was Blocked by Maackiain
Authors: Kuo Yun-Hua , Hung Huey-Shan , Tsai Chia-Wen , Chiu Shao-Chih , Liu Shih-Ping , Chiang Yu-Ting , Shyu Woei-Cherng , Lin Shinn-Zong , Fu Ru-Huei
Published: August 2022

Brain-enriched myelin-associated protein 1 (BCAS1) is frequently highly expressed in human cancer, but its detailed function is unclear. Here, we identified a novel splice variant of the BCAS1 gene in glioblastoma multiforme (GBM) named BCAS1-SV1. The expression of BCAS1-SV1 was weak in heathy brain cells but high in GBM cell lines. The overexpression of BCAS1-SV1 significantly increased the proliferation and migration of GBM cells, whereas the RNA-interference-mediated knockdown of BCAS1-SV1 reduced proliferation and migration. Moreover, using a yeast-two hybrid assay, immunoprecipitation, and immunofluorescence staining, we confirmed that β-arrestin 2 is an interaction partner of BCAS1-SV1 but not BCAS1. The downregulation of β-arrestin 2 directly enhanced the malignancy of GBM and abrogated the effects of BCAS1-SV1 on GBM cells. Finally, we used a yeast two-hybrid-based growth assay to identify that maackiain (MK) is a potential inhibitor of the interaction between BCAS1-SV1 and β-arrestin 2. MK treatment lessened the proliferation and migration of GBM cells and prolonged the lifespan of tumor-bearing mice in subcutaneous xenograft and intracranial U87-luc xenograft models. This study provides the first evidence that the gain-of-function BCAS1-SV1 splice variant promotes the development of GBM by suppressing the β-arrestin 2 pathway and opens up a new therapeutic perspective in GBM.
Novel Necroptosis-Related Gene Signature for Predicting Early Diagnosis and Prognosis and Immunotherapy of Gastric Cancer
Authors: Zhou Xiaozhu , Zhang Baizhuo , Zheng Guoliang , Zhang Zhen , Wu Jiaoqi , Du Ke , Zhang Jing
Published: August 2022

Necroptosis is a kind of programmed necrosis, which is different from apoptosis and pyroptosis. Its molecular mechanism has been described in inflammatory diseases. Gastric cancer (GC) is one of the most common malignancies worldwide with the third highest mortality. However, the role of necroptosis in the occurrence and progression of GC remains largely unexplored. Therefore, we investigated necroptosis-related genes (NRGs) by analyzing public transcriptomic data from GC samples. Our results indicate that 83 of 740 NRGs are dysregulated in GC tissues. Next, we identified necroptosis-associated early diagnosis and prognostic gene signatures for GC using machine learning. 2-NRGs (CCT6A and FAP) and 4-NRGs (ZFP36, TP53I3, FAP, and CCT6A), respectively, can effectively assess the risk of early GC (AUC = 0.943) and the prognosis of GC patients (AUC = 0.866). Through in-depth analysis, we were pleasantly surprised to find that there was a significant correlation between the 4-NRGs and GC immunotherapy effect and immune checkpoint inhibitors (ICIs), which could be used for the evaluation of immunosuppressants. Finally, we identified the core gene FAP, and established the relationship between FAP and ICIs in GC. These findings could provide a new target for immunotherapy for GC and a more effective treatment scheme for GC patients.
Synthesis of 2-Alkylaryl and Furanyl Acetates by Palladium Catalysed Carbonylation of Alcohols
Authors: Sole Roberto , Cappellazzo Jacopo , Scalchi Leonardo , Paganelli Stefano , Beghetto Valentina
Published: August 2022

The one-pot alkoxycarbonylation of halo-free alkylaryl and furanyl alcohols represents a sustainable alternative for the synthesis of alkylaryl and furanyl acetates. In this paper, the reaction between benzyl alcohol, chosen as a model substrate, CH3OH and CO was tested in the presence of a homogeneous palladium catalyst, an activator (isopropenyl acetate (IPAc) or dimethyl carbonate (DMC)) and a base (Cs2CO3). The influence of various reaction parameters such as the CO pressure, ligand and palladium precursor employed, mmol% catalyst load, temperature and time were investigated. The results demonstrate that decreasing the CO pressure from 50 bar to 5 bar at 130 °C for 18 h increases yields in benzyl acetate from 36% to over 98%. Further experiments were performed in the presence of piperonyl and furfuryl alcohol, interesting substrates employed for the synthesis of various fine chemicals. Moreover, furfuryl alcohol is a lignocellulosic-derived building block employed for the synthesis of functionalized furans such as 2-alkylfurfuryl acetates. Both the alcohols were successfully transformed in the corresponding acetate (yields above 96%) in rather mild reaction conditions (5–0.01 mol% catalyst, 5–2 bar CO pressure, 130 °C, 4–18h), demonstrating that the alkoxycarbonylation of alcohols represents a promising sustainable alternative to more impactful industrial practices adopted to date for the synthesis of alkylaryl and furfuryl acetates.
Main Cations and Cellular Biology of Traumatic Spinal Cord Injury
Authors: Munteanu Constantin , Rotariu Mariana , Turnea Marius , Ionescu Anca Mirela , Popescu Cristina , Spinu Aura , Ionescu Elena Valentina , Oprea Carmen , Țucmeanu Roxana Elena , Tătăranu Ligia Gabriela , Silișteanu Sînziana Calina , Onose Gelu
Published: August 2022

Traumatic spinal cord injury is a life-changing condition with a significant socio-economic impact on patients, their relatives, their caregivers, and even the community. Despite considerable medical advances, there is still a lack of options for the effective treatment of these patients. The major complexity and significant disabling potential of the pathophysiology that spinal cord trauma triggers are the main factors that have led to incremental scientific research on this topic, including trying to describe the molecular and cellular mechanisms that regulate spinal cord repair and regeneration. Scientists have identified various practical approaches to promote cell growth and survival, remyelination, and neuroplasticity in this part of the central nervous system. This review focuses on specific detailed aspects of the involvement of cations in the cell biology of such pathology and on the possibility of repairing damaged spinal cord tissue. In this context, the cellular biology of sodium, potassium, lithium, calcium, and magnesium is essential for understanding the related pathophysiology and also the possibilities to counteract the harmful effects of traumatic events. Lithium, sodium, potassium—monovalent cations—and calcium and magnesium—bivalent cations—can influence many protein–protein interactions, gene transcription, ion channel functions, cellular energy processes—phosphorylation, oxidation—inflammation, etc. For data systematization and synthesis, we used the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) methodology, trying to make, as far as possible, some order in seeing the “big forest” instead of “trees”. Although we would have expected a large number of articles to address the topic, we were still surprised to find only 51 unique articles after removing duplicates from the 207 articles initially identified. Our article integrates data on many biochemical processes influenced by cations at the molecular level to understand the real possibilities of therapeutic intervention—which must maintain a very narrow balance in cell ion concentrations. Multimolecular, multi-cellular: neuronal cells, glial cells, non-neuronal cells, but also multi-ionic interactions play an important role in the balance between neuro-degenerative pathophysiological processes and the development of effective neuroprotective strategies. This article emphasizes the need for studying cation dynamics as an important future direction.
From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review
Authors: Lucignani Giulia , Guarnera Alessia , Rossi-Espagnet Maria Camilla , Moltoni Giulia , Antonelli Amanda , Figà Talamanca Lorenzo , Carducci Chiara , Calo Carducci Francesca Ippolita , Napolitano Antonio , Gandolfo Carlo , Campi Francesca , Auriti Cinzia , Parazzini Cecilia , Longo Daniela
Published: August 2022

Congenital infections represent a challenging and varied clinical scenario in which the brain is frequently involved. Therefore, fetal and neonatal neuro-imaging plays a pivotal role in reaching an accurate diagnosis and in predicting the clinical outcome. Congenital brain infections are characterized by various clinical manifestations, ranging from nearly asymptomatic diseases to syndromic disorders, often associated with severe neurological symptoms. Brain damage results from the complex interaction among the infectious agent, its specific cellular tropism, and the stage of development of the central nervous system at the time of the maternal infection. Therefore, neuroradiological findings vary widely and are the result of complex events. An early detection is essential to establishing a proper diagnosis and prognosis, and to guarantee an optimal and prompt therapeutic perinatal management. Recently, emerging infective agents (i.e., Zika virus and SARS-CoV2) have been related to possible pre- and perinatal brain damage, thus expanding the spectrum of congenital brain infections. The purpose of this pictorial review is to provide an overview of the current knowledge on fetal and neonatal brain neuroimaging patterns in congenital brain infections used in clinical practice.
Analysis of COVID-19 Risk Perception and Its Correlates among University Students in Ghana
Authors: Quansah Frank , Anin Stephen Kofi , Hagan John Elvis , Agormedah Edmond Kwesi , Oduro Prince , Srem-Sai Medina , Frimpong James Boadu , Schack Thomas
Published: August 2022

Monitoring students’ risk perception forms part of emergency management during public health emergencies. Thus, public risk perception generally triggers attitudes, emotional responses, and prevention behaviors, which affect the evolution of emergencies and disease control strategies. However, research has paid less attention to the COVID-19 risk perception of students in Ghana. This study assessed the prevalence of COVID-19 risk perception and further identified its correlates among university students. In this study, 882 students from two public universities in Ghana were conveniently recruited. The data were analysed using frequency counts, percentages, and ordered logistic regression. The study revealed the prevalence of a high degree of COVID-19 risk perception among almost half (47.4%) of the sampled students. Results from ordered logistic regression analysis showed that age, sex, religion, use of professional and social media platforms, level (years) of study, and COVID-19 knowledge were significant correlates of COVID-19 risk perception. The dissemination of appropriate COVID-19 information and behavior-change communication to such relatively high-risk behavior sub-groups could help counter the debilitative effects of non-altruistic attitudes because of COVID-19 risk perception.
Study on the Bandgap Characteristics and Vibration-Reduction Mechanism of Symmetric Power-Exponent Prismatic Phononic Crystal Plates
Authors: Jin Xing , Zhang Zhenhua
Published: August 2022

In this paper, a symmetric power-exponent prismatic phononic crystal configuration was proposed for the vibration reduction of thin plate structures, and the mechanism of bandgap generation and the influencing factors of the band gaps were analyzed. The results showed that the proposed symmetric power-exponent prismatic phononic crystal structure has three complete band gaps of bending waves, where the width of the second band gap can go up to 1639 Hz. The band gaps of bending waves of the phononic crystal were verified using a combination of numerical simulations and experimental methods, and subsequently, the bandgap characteristics and energy-focusing effect of the phononic crystals were effectively used to suppress the bending vibration of the thin plate. With the increase in prismoid height of the structure, the width of the first band gap expanded, while the bandwidths of the other two band gaps narrowed down. It was observed that an increase in the power of the power-exponent prismoid would reduce the starting and ending frequencies of the band gaps, whereas an increase in the prismoid edge thickness would weaken the energy-focusing effect and narrow the band gaps gradually. Our research results provide a new technique and a pathway to realize vibration reduction in thin plate structures.
Study on Deposition Conditions in Coupled Polysilicon CVD Furnaces by Simulations
Authors: Zhang Shengtao , Fu Hao , Fan Guofeng , Li Tie , Han Jindou , Zhao Lili
Published: August 2022

Electronic-grade polysilicon is the cornerstone of the information industry. Considering the demand for this material in the semiconductor industry, any technological improvement has great potential benefits. Due to the quality requirements of electronic polysilicon, its preparation process is characterized by low raw material utilization and high cost. Simply increasing the deposition rate by increasing the chemical reaction rate will easily lead to a reduction in the proportion of dense materials. For the first time, a coupled furnace scheme is proposed to improve the utilization of raw materials while maintaining the same deposition quality. The deposition conditions on the surface of silicon rods with different base plate designs were modeled and analyzed using the software PolySim, and a design characterized by a high flow rate and the use of 9 mm and 15 mm nozzles was selected for the coupling scheme. In coupling mode, the simulation results show that the utilization of raw materials is increased by 17.5%, and the deposition rate is increased by 44.9%, while the deposition quality and uniformity remain approximately unchanged. The results show that the coupling scheme with high feed flow is beneficial for significantly improving the deposition conditions and the utilization rate of raw materials, which also provides guidance for material preparation processes with similar principles.
Effect of Electrolysis Temperature on the Preparation of FeO by Molten Salt Electrolysis
Authors: Jing Zhenwei , Luo Chao , Yan Hongyan , Meng Ju , Li Chenxiao , Li Hui , Liang Jinglong
Published: August 2022

FeO is a low-price material with high charge storage capacity, biocompatibility and other characteristics. It has been applied in the fields of catalysts, capacitors, electrodes and composite materials. However, the current method of preparing FeO needs to control the temperature and reducing atmosphere, which increase the production difficulty and cost. In this experiment, the molten salt electrolysis method was used to prepare FeO by using the NaCl-KCl molten salt system and Fe2O3 and Al2O3 as raw materials, and the influence of temperature on the preparation process was explored. The results showed that the electrolysis process of Fe2O3 to FeO is mainly divided into the following three stages: the electric double-layer charging process, Fe2O3 to Fe3O4 process and Fe3O4 to FeO process. The increase in temperature can improve the reaction speed and strengthen the electrolysis effect. The higher the temperature, the less Fe3O4 and more FeO in the sample. Through analysis, it was found that the increase in temperature will affect the theoretical voltage of the electrolytic reaction in thermodynamics, resulting in the increase in the overall potential provided by the power supply. In terms of kinetics, the increase in temperature will affect the viscosity of molten salt, so that O2− transport has better kinetic conditions.