bluuebunny/crossref_metadata_2025 huggingface dataset:
¿Qué comparten los académicos de un grupo de investigación? Un caso de estudio crítico
Authors: Hernández-Soto Roberto , Gutiérrez-Ortega Mónica , Rubia-Avi Bartolomé
Published: April 2023

The purpose of this study is to investigate the content of knowledge sharing among academics. The aim is to make an empirical contribution to a practically unresearched topic in the national (Spanish) and international context. To this purpose, an exploratory analysis based on a critical case study was proposed. Sixteen interviews were conducted with members of a research group at a Spanish public university. The results reveal that academics share elements of explicit, tacit and emotional support related to teaching, research and knowledge transfer. It has been found that the exchange refers preferentially to the field of research and that there are differences between senior and junior researchers in terms of the type of knowledge and emotional support they give and receive. This study shows that the tacit nature of knowledge can hinder its transfer and that emotional support, as part of social support, can favor knowledge sharing practices among academics.

El propósito de este estudio es investigar el contenido del intercambio de conocimiento entre los académicos. Se pretende realizar una contribución empírica a un aspecto prácticamente inédito en el contexto nacional (español) e internacional. Para ello se planteó un análisis exploratorio basado en un caso de estudio crítico. Se realizaron 16 entrevistas a miembros de un grupo de investigación de una universidad pública española. Los resultados revelan que los académicos intercambian elementos de carácter explícito, tácito y apoyo emocional relacionados con la docencia, la investigación y la transferencia de conocimiento. Se ha constatado que el intercambio se refiere preferentemente al ámbito de la investigación y que existen diferencias entre los investigadores senior y junior en cuanto al tipo de conocimiento y al apoyo emocional que dan y reciben. Este estudio demuestra que el carácter tácito del conocimiento puede dificultar su transferencia y que el apoyo emocional, como parte del apoyo social, puede favorecer las prácticas de intercambio entre los académicos.
Medición de la calidad en los servicios sanitarios públicos. El caso de Osakidetza – Servicio vasco de salud
Authors: Cano Fernández Francisco Javier , Esteban Galarza Marisol
Published: April 2023

Este artículo trata sobre la medición de la calidad en los servicios sanitarios públicos del País Vasco, cuya provisión corresponde al ente público Osakidetza – Servicio vasco de salud. Se describen métodos y herramientas de calidad generales en el ámbito de la gestión empresarial y sanitaria, junto con otras específicas de Osakidetza, a las que, estas últimas, se les dedica un análisis más profundo. En concreto, el concepto de calidad se ha estudiado desde una perspectiva poliédrica, que incluye diferentes aspectos del término, tales como la calidad contratada frente a la calidad financiada; la calidad certificada, comparada, percibida y evaluada. La principal conclusión es la constatación de la importancia que en el Servicio vasco de salud tienen los objetivos orientados a la calidad del servicio sanitario y calidad de la gestión. Estos se consiguen, entre otros, mediante el conocimiento de la percepción que tienen sus pacientes y usuarios de la atención sanitaria recibida a través de encuestas de satisfacción, así como del establecimiento de compromisos de calidad contratados que cuando son alcanzados reciben financiación específica a través de la fórmula de formalización de contratos programa.
Cooperating for a better future
Authors: Krugman Paul
Published: April 2023

This paper addresses what I consider to be the world’s main problems, although I recognise that there are also other problems at present, such as inflation and the war in Ukraine. I will try to address the main problems, which are of interest to CIRIEC, which is an international organisation that pays particular attention to what is called the Third Sector” or “Social Economy”, an area that lies between the private business sector and the government despite I am not, I must admit, an expert in this last field. I will deal with it in the context of discussing a couple of problems we face in the world that I think are really important. The first problem is economic inequality, which I know something about. The second problem is climate change and environmental problems, which I think are the most important. I will also refer at the end to some problems related to the COVID pandemic. In all the problems, what we could call the Third Sector can play a big role.
Do loneliness, perceived stress, and communication skill with peers predict social problem-solving in freshmen during COVID-19 pandemic?
Authors: Putri Dona Eka , Rahardjo Wahyu , Pranandari Kenes , Rini Quroyzhin Kartika , Qomariyah Nurul
Published: April 2023

The condition of the COVID-19 pandemic has resulted in the enactment of physical distancing and staying at home policy. With this isolation, face-to-face activities are replaced by online activities. Several studies have found that distancing has an impact on increasing anxiety and stress in college students. This is inseparable from their ability in social problem-solving. The aim of this study was to determine how loneliness, perceived stress, communication skills with peers influence social problem-solving. Participants were 702 freshmen from University X and domiciled in the Jakarta Greater Area and several other cities. The instruments were the Social Problem-Solving Inventory-Revised Short-Form, UCLA Loneliness Scale Short Version (ULS-8), Perceived Stress Scale, and the Interpersonal Communication Scale. The data was collected through an online questionnaire and were analyzed using hierarchical regression. The dynamics of research results show that loneliness has a significant effect on social problem-solving. When perceived stress is included in the model, the effect of loneliness on social problem-solving decreases and tends to be weak, although still significant, the effect of perceived stress is much stronger. When communication skills with peers are included in the model, the effect of loneliness is no longer significant and the effect of perceived stress decreases, but it becomes the strongest variable affecting social problem-solving. On the other side, the three independent variables have a great influence on solving social problems in freshmen.
Outros olhares de Celso Furtado sobre o presidente JK
Authors: Jurgenfeld Vanessa Follmann
Published: April 2023

Uma análise comparada sobre a interpretação do presidente de Juscelino Kubitschek (JK) presente em dois livros da extensa obra de Celso Furtado é o foco deste ensaio. As revelações trazidas pela recente publicação do livro “Diários Intermitentes”, ocorrida em 2019, indicam uma dose de crítica mais acentuada à política econômica e à personalidade de JK em relação ao que já havia sobre o ex-presidente na obra “A Fantasia Desfeita”, publicada pela primeira vez em 1989 por Furtado.
O campo de ensino superior em cooperativismo no Rio Grande do Sul
Authors: Neumann Alves Cinara , Cadoná Marco André
Published: April 2023

O artigo apresenta uma análise da estrutura de relações estabelecidas por docentes no campo de ensino superior em cooperativismo no Estado do Rio Grande do Sul - Brasil. Evidencia-se as ações e, principalmente, as posições dos docentes no campo de ensino superior em cooperativismo no Estado com base na noção de campo de Bourdieu, dados de uma pesquisa documental e de entrevistas semiestruturadas realizadas com gestores e professores de cursos superiores em cooperativismo. Apresenta-se um breve histórico da construção dos cursos superiores em cooperativismo a partir da narrativa e posição dos agentes no campo. A partir da compreensão de quem são esses docentes apresenta-se, também, uma taxonomia dos docentes de ensino superior em cooperativismo no Rio Grande do Sul, identificando-se a presença de três categorias: os Docentes Institucionais, os Docentes Não Institucionais e os Docentes Mercadológicos. Observa-se, ao final, a existência de uma rede de atuação docente no âmbito da pós-graduação, reflexo também da estrutura de relações destes docentes. Os agentes desse campo estabelecem suas relações a partir da categoria de docente a qual pertencem, e validam os capitais que essa categoria apresenta. Mas há um processo em andamento, que dispõe e transforma essas relações e passa pela compreensão da construção histórica do campo.
Política de expansão do ensino superior e a Política Nacional de Desenvolvimento Regional
Authors: Beulck Pahim Frank Sammer , Kocourek Sheila , Martins Santos Gilberto
Published: April 2023

Esta pesquisa busca analisar a Política de Expansão do Ensino Superior com base nos resultados da classificação pela tipologia sub-regional do Plano Nacional de Desenvolvimento Regional (PNDR). A análise verifica o comportamento da economia, nos municípios onde foram implantados os novos campi no programa de expansão do ensino superior. A metodologia da pesquisa envolve a busca de dados e informações em fontes públicas por meio de análise documental e a revisão de literatura em diferentes bases de pesquisa. As fontes analisadas focam nas contribuições da expansão do ensino superior, com o processo de Desenvolvimento Regional (DR), tendo como sustentação as políticas públicas de educação superior no objetivo de redução de desigualdades. A seleção de municípios, com novos campi de universidades públicas, considera a tipologia da PNDR como um novo caminho para a avaliação destas contribuições. Os resultados demonstram a importância da tipologia sub-regional da PNDR como mecanismo de análise do comportamento econômico de municípios e microrregiões, bem como evidenciam a importância de novas pesquisas sobre os fatores que influenciam nos resultados da classificação e consequentemente a contribuição dos campi a essas microrregiões.
Potential Edible Film Biocomposite (Canna Starch, Nanochitosan and Fish Oil) for Extend Shelf Life Pangasius Sausages Based on Organoleptic Characteristics, Water Content, and pH: A Review
Authors: Rinaldi Al Marisa , Rochima Emma , Untung Mochamad , Rostini Iis
Published: April 2023

In general, commercial sausages can only last at room temperature for 1 day, because sausages are made from raw materials that are easily degraded in quality, especially fish sausages where fish are included in perishable foods that are easily degraded due to the high water content in fish which is suitable for microbial growth so a solution is needed to overcome these problems. Biocompote film made from fish oil, nano chitosan and canna starch has the potential to be used as a packaging substitute for casings that are more environmentally friendly and can extend the shelf life by analyzing pH, water content and organoleptic to determine the effect of the application of edible film on catfish sausages.
Determination of Heavy Metals in Edible Palm Oil Adultrated with Plant Dye: Experimental Investigation
Authors: Frances Ejimofor Chiamaka , Johnson Oledibe Odira , Enoch Nwakoby Nnamdi , Eziamaka Afam-Ezeaku Chikaodili , Ann Mbaukwu Onyinye
Published: April 2023

From generation to generation, edible palm oil has been a staple of the human diet and has improved both nutrition and health. The goal of the current research was to determine whether it was possible to tamper with palm oil by adding natural potash (lake salt) and red dye made from the leaf sheath of sorghum bicolor. In order to create tainted palm oil with known concentrations and adulterant ratios, concentrations of potash and red dye ranging from 0.01-0.1% and 0.1-1.0%, respectively, were produced in water and added to fresh palm oil at oil/adulterant ratios ranging from 10:1-10:10. Adulterated samples underwent visual inspection for appearance, as well as sensory evaluation for quality indicators. Even at concentrations below 0.01%, the addition of potash caused the typical orange red hue of palm oil to become yellowish red, and it also produced a product with improved consistency. Zn 8.060.06, Cd 1.010.05, Ni 1.000.00, Co 125.910.09, Pb 9.300.07 Cobalt, Lead, and other heavy metals were found to be over the detectable level of the WHO standard, whereas Cd and Ni were within the permissibility limit. The findings of this study suggest that if sufficient oversight is not provided by regulatory bodies, palm oil might pose a risk to the public's health. As a result, from the point of production to the point of consumption, our local processed palm oil has to be better screened.
Effect of Nitrogen and Weed Management Practices on Growth and Yield of Blackgram (Vigna mungo L.)
Authors: Priyadarshini Samprikta , Singh Rajesh , Indu Thakur , Jakhad Ajeet
Published: April 2023

A research trail was conducted in Kharif 2022, at Crop research form, SHUATS, Prayagraj. To study the “Effect of nitrogen and weed management practices on growth and yield of Blackgram” (Vigna mungo L.). The treatments consist of three levels of nitrogen (15, 30 and 45 kg/ha) and weed management practices (Hand weeding twice (20 & 40 DAS), Pendimethalin (0.75ml/ha) Pre-emergence (5 DAS), Imazethapyr (75g/ha) Post-emergence (25 DAS) are included. Experiment were laid out in randomized block design with 10 treatments each replicated thrice. The result showed that viz: significantly higher plant height (64.49 cm), number of nodules/plant (23.80), number of branches/plant (6.40), pods/plant (32.13), seeds/pod (8.20), grain yield (1223.33 kg/ha), Stover yield (2472.67 kg/ha), lower weed population/m2 (4.06) recorded in (treatment 9) Nitrogen (45 kg/ha) + Imazethapyr (75 g/ha) Post-emergence.
Microfluidic Continuous Modification of Magnetic Nanoparticles for Circulating Tumor Cell Capture and Isolation
Authors: Zhang Changqing , Lin Jianwei , Yu Yunru , Deng Dawei , Yu Ying , Zhang Dagan , Zhong Qifeng
Published: April 2023

Circulating Tumor Cells (CTCs) enrichment technology refers to medical approaches for capturing and isolating target tumor cells, which has drawn great attention owing to its applications in the clinic such as cancer diagnosis and prognosis. Magnetic nanoparticles have emerged as an important platform for CTCs capture and isolation. However, due to the inert surface nature, the molecular phenotype analysis of CTCs and identification sensitivity remain a huge challenge. Herein, an ultrasound‐activated microfluidic method is presented for rapid basic modification of magnetic nanoparticles, laying the foundation for further covalently binding of functional groups to capture CTCs. In this work, Fe3O4@SiO2 nanoparticles obtained from microfluidics are hybridized with folic acid for the capture and isolation of CTCs with folate receptors such as Hela cells. The usage of microfluidic technology to upgrade Fe3O4 nanoparticles provides the possibility for improving the detective efficiency of rare cells associated with malignancies, which sheds new light on future clinical applications.
A Bochev‐Dohrmann‐Gunzburger stabilized method for Maxwell eigenproblem
Authors: Du Zhijie , Duan Huoyuan , Wang Can , Zhang Qiuyu
Published: April 2023

A stabilized mixed finite element method is proposed for solving the Maxwell eigenproblem in terms of the electric field and the multiplier. Using the Bochev‐Dohrmann‐Gunzburger stabilization, we introduce some ad hoc stabilizing parameters for stabilizing the kernel‐coercivity of the electric field and for stabilizing the inf‐sup condition of the multiplier. We show that the stabilized mixed method is stable and convergent, with applications to some lowest‐order edge elements on affine rectangular and cuboid mesh and on nonaffine quadrilateral mesh which fail in the classical methods. In particular, we prove the uniform convergence for guaranteeing spectral‐correct and spurious‐free discrete eigenmodes from the Babus̆ka‐Osborn spectral theory for compact operators. Numerical results have illustrated the performance of the stabilized method and confirmed the theoretical results obtained.
Trust rhetoric and CEO gender
Authors: Breuer Wolfgang , Knetsch Andreas , Salzmann Astrid Juliane
Published: April 2023

This study investigates the perceived and actual trustworthiness of female managers when using rhetoric to advertise their trustworthiness in public disclosure documents. We find that the stock market reacts more favorably to trust rhetoric if the document has been prepared under the responsibility of a female CEO rather than a male CEO. We rule out that this result could be driven by female and male CEOs talking about trust in different contexts. However, inconsistently with the notion that the trust rhetoric of women managers is more truthful than that of their male counterparts, trust rhetoric does not relate to less extensive earnings manipulation if such rhetoric stems from female CEOs compared to male CEOs. Our results thus do not confirm the popular view that higher female trustworthiness explains gender differences in accounting behavior.
Isotopic decoupling of K from Sr and Nd in the Saima alkaline complex, NE China: interactions of cratonic roots and asthenosphere
Authors: Gao Nan , Xu Yingkui , Zhu Dan , Li Yang , Li Xiongyao , Liu Jianzhong , Luo Jin-Cheng
Published: April 2023

We report high-precision K isotopes, apatite U–Pb ages, whole-rock elements and Sr–Nd isotopes for the Saima nephelite syenite in the North China Craton. Trace-element and Sr–Nd–Hf–O isotope data indicate the presence of subducting sediments in the source region, while K isotopic compositions show a narrow range between –0.54 ‰ and –0.28 ‰, with an average of –0.41 ± 0.06 ‰, identical to the value of the asthenosphere. The nearly identical K isotopic compositions are low probability events compared with the K isotopic compositions of island arc lavas reported previously (–1.55 ‰ to +0.2 ‰). Although crustal contamination is consistent with the Sr–Nd–K isotopic data, alternatively we propose that the isotopic data also reconcile with the interaction between cratonic roots and the underlying convective asthenosphere, if this interaction is over prolonged periods of time. Numerical simulations successfully reproduced the observed data, if the metasomatism of the lithospheric mantle root, the source of the Saima alkaline rocks, occurred 500 Ma ago. Our study reveals that the isotopic compositions of fast-diffusion components in a lithospheric mantle metasomatized by ancient subducting melts can be effectively homogenized by convective asthenosphere through diffusion over a long time interval.
A retrospective study on the outcomes of stapedotomy with vein graft interposition and vein graft surround techniques
Authors: Colvin S , Lepcha A , Augustine A M , Philip A , Mammen M D
Published: April 2023

Objective

This study evaluated audiological outcomes of stapedotomy using two different techniques, vein graft interposition and vein graft surround, for sealing the stapes fenestra.

Method

A retrospective study of 130 patients who underwent stapedotomy for otosclerosis was performed. A total of 84 patients underwent the vein graft surround procedure and 46 underwent the vein graft interposition procedure. Post-operative hearing outcome was compared between them.

Results

A total of 55 of 130 patients had a post-operative air–bone gap of less than 10 dB. A total of 57 patients had an air–bone gap within 20 dB. The average air–bone gap was 13.16 dB at 3 months with a mean improvement of 22.06 dB (11.98 dB for vein graft interposition and 13.80 dB for vein graft surround; p = 0.79).

Conclusion

There was no significant difference in hearing outcome between the two techniques. The vein graft interposition technique is preferred for large fenestra or stapedectomy cases and in cerebrospinal fluid gusher cases. The vein graft surround technique is easier to perform and preferred in small fenestra stapedotomy.
Children's interactions with virtual assistants: Moving beyond depictions of social agents
Authors: Girouard-Hallam Lauren N. , Danovitch Judith H.
Published: April 2023

Clark and Fischer argue that people see social robots as depictions of social agents. However, people's interactions with virtual assistants may change their beliefs about social robots. Children and adults with exposure to virtual assistants may view social robots not as depictions of social agents, but as social agents belonging to a unique ontological category.
Familial sources of encouragement and breast-feeding practices among women participating in the US Special Supplemental Nutrition Programme for Women, Infants and Children
Authors: Channell Doig Amara , Aparicio Elizabeth M , Gallo Sina
Published: April 2023

Objective:

To explore how sources of familial encouragement are associated with breast-feeding initiation and duration among a national sample participating in the US Special Supplemental Nutrition Program for Women, Infants, and Children (WIC).

Design:

This study uses the 2013–2015 WIC Infant and Toddler Feeding Practices Study 2 (WIC ITFPS-2) data. Breast-feeding initiation was measured at the first month, while duration was derived from a composite of the first 13 months. The analysis used logistic and linear regression to explore the association between encouragement sources and breast-feeding outcomes.

Setting:

A nationally representative sample of WIC participants in the USA.

Participants:

WIC participants who completed the 13-month interview of the WIC ITFPS-2 (n2807).

Results:

Encouragement was significantly associated with both initiation and duration. Each source of encouragement was associated with a 3·2 (95 % CI 2·8, 3·8) increase in odds of initiating breast-feeding in the unadjusted model and 3·0 (95 % CI 2·5, 3·6) increased odds, controlling for age, education, nativity, poverty status, race and ethnicity (<0·0001). When predicting log duration, each percent increase in source of encouragement was associated with an increasing duration on average by 0·003 d (95 % CI 0·2, 0·3, <0·0001). When controls were added, it was associated with an increase of an average of 0·002 d (95 % CI 0·2, 0·3) per percent increase in encouragement source (<0·0001).

Conclusions:

Women who receive encouragement appear to be more likely to breastfeed. Additional work is needed to explore sources of encouragement and how to include them in intervention work.
On quantification and maximization of information transfer in network dynamical systems
Authors: Singh Moirangthem Sailash , Pasumarthy Ramkrishna , Vaidya Umesh , Leonhardt Steffen
Published: April 2023

Information flow among nodes in a complex network describes the overall cause-effect relationships among the nodes and provides a better understanding of the contributions of these nodes individually or collectively towards the underlying network dynamics. Variations in network topologies result in varying information flows among nodes. We integrate theories from information science with control network theory into a framework that enables us to quantify and control the information flows among the nodes in a complex network. The framework explicates the relationships between the network topology and the functional patterns, such as the information transfers in biological networks, information rerouting in sensor nodes, and influence patterns in social networks. We show that by designing or re-configuring the network topology, we can optimize the information transfer function between two chosen nodes. As a proof of concept, we apply our proposed methods in the context of brain networks, where we reconfigure neural circuits to optimize excitation levels among the excitatory neurons.
Gewinnschwellenanalyse bei Bildgebungsgeräten: Grundlegende Einführung mit Vorstellung eines nutzungsfreundlichen Tools zur klinikinternen Kalkulation am Beispiel PET/CT
Authors: Zippel Claus , Antke Christina , Mori Yuriko , Sombetzki Antje , Antoch Gerald , Giesel Frederik L.
Published: April 2023

Hintergrund Bildgebungsgeräte wie die PET/CT werden angesichts des wachsenden Spektrums an innovativen nuklearmedizinischen Diagnostikverfahren immer wichtiger. Da sowohl die Beschaffung und Inbetriebnahme als auch der laufende Betrieb von Bildgebungsgeräten zu vergleichsweise hohen Kosten führen, ist aus Klinik-/Praxissicht von Interesse, ab welcher Leistungsmenge der (geplante) Gerätebetrieb zu einem Gewinn führt. Im Folgenden stellen wir die Gewinnschwellenanalyse als betriebswirtschaftliche Methode zur Gewinn- und Verlustplanung wie auch ein Kalkulationstool vor, das Anwender in nuklearmedizinischen Kliniken und Praxen grundlegend zur Gewinnschwellenanalyse am Beispiel PET/CT nutzen können.

Methodik Bei der Gewinnschwellenanalyse wird der Schnitt- respektive Übergangspunkt ermittelt, ab dem die unternehmens-/bereichs- bzw. gerätespezifischen Erlöse die für den Betrieb anfallenden Gesamtkosten für Personal-, Sachmittel usw. übersteigen. Hierfür gilt es, auf der Kostenseite die fixen und variablen (Plan-)Kostenbestandteile für Gerätebeschaffung und -betrieb sowie auf der Erlösseite die jeweils gerätebezogene (Plan-)Erlösstruktur aufzubereiten.

Ergebnisse Die Autoren stellen die Methode der Gewinnschwellenanalyse am Beispiel der geplanten Beschaffung bzw. des fortlaufenden Betriebs eines PET/CT dar. Darüber hinaus wird ein Kalkulationstool vorgestellt, das interessierte Nutzer bei der Erstellung einer einrichtungsspezifischen Gewinnschwellenanalyse unterstützend nutzen können. Hierzu wird auf ausgewählte Kosten- und Leistungs-/Erlösdaten eingegangen, die intern zusammenzutragen und aufzubereiten sowie in vorbereitete Tabellenblätter einzutragen sind.

Schlussfolgerung Mittels Gewinnschwellenanalyse lässt sich der Gewinn/Verlust(-punkt) für den (geplanten) Betrieb von Bildgebungsgeräten wie der PET/CT bestimmen. Nutzer aus Bildgebungskliniken/-praxen und Administration können das vorgestellte Kalkulationstool einrichtungsspezifisch anpassen und damit als Basisdokument sowohl für die vorbereitende Beschaffung als auch die fortlaufende Betriebssteuerung von Bildgebungsgeräten im Klinik-/Praxisalltag nutzen.
Convergence analysis of the Halpern iteration with adaptive anchoring parameters
Authors: He Songnian , Xu Hong-Kun , Dong Qiao-Li , Mei Na
Published: April 2023

We propose an adaptive way to choose the anchoring parameters for the Halpern iteration to find a fixed point of a nonexpansive mapping in a real Hilbert space. We prove strong convergence of this adaptive Halpern iteration and obtain the rate of asymptotic regularity at least

O
(
1

/

k
)

O(1/k)

, where

k
k

is the number of iterations. Numerical experiments are also provided to show advantages and outperformance of our adaptive Halpern algorithm over the standard Halpern algorithm.
Mowers versus growers: Riparian buffer management in the Southern Blue Ridge Mountains, USA
Authors: Sanders Jennifer M. , Jackson C. Rhett , Welch‐Devine Meredith
Published: April 2023

Despite long‐standing knowledge of the benefits of riparian buffers for mitigating nonpoint source pollution, many streams are unprotected by buffers. Even landowners who understand ecological values of buffers mow riparian vegetation to the streambank. Do trends in rural riparian conditions reflect the development of riparian forest science? What motivates residential riparian management actions? Using high‐resolution orthoimagery, we quantified riparian conditions and trends between 1998 and 2015 in the rural upper Little Tennessee River basin in Macon County, North Carolina and explored how landowners view riparian zone management and riparian restoration programs. Buffer composition in 2015 was as follows: no buffer (32.5%), narrow (19.3%), forested (26.7%), shrub (7.2%), and intermediate (7.0%). Relative to 1998, the greatest decrease occurred in the no buffer class (−17.7%, 46 km) and the largest increases occurred in the shrub (+72.5%, 20 km) and narrow (12.6%, 14 km) classes. Forested buffer marginally increased. Semi‐structured interview data suggest that landowners prioritize recreational and scenic aspects of riparian buffers over ecological functions such as filtration and bank stabilization. Riparian restoration programs might be made more enticing to non‐adopters if outreach language appealed to landowner priorities, design elements demonstrated intentional management, and program managers highlighted areas where ecological goals and landowner values align.
Intravenous Lipid Emulsion does NOT have a role in severe poisoning: CON
Authors: Graudins Andis , Lee Hwee Min D. , Tong Lien Kien Roger
Published: April 2023

Intravenous lipid emulsion (ILE) has been suggested as a potential universal antidote for cardiovascular and central nervous system toxicity resulting from a multitude of pharmaceutical and nonpharmaceutical poisonings. While there is some evidence to suggest that ILE may have a positive effect in cardiovascular system toxicity after accidental intravenous lipophilic local anaesthetic overdose, this cannot be extrapolated to cases of severe poisoning resulting from oral drug overdose. Treatment recommendations are based upon variable outcome animal studies and low‐level clinical evidence with a significant degree of positive reporting bias. Currently, there is a paucity of controlled clinical data to support ILE use to treat severe drug poisoning after oral overdose. ILE use should be limited to well‐designed, ethically approved, controlled clinical trials aimed at determining the true effectiveness of this therapy. This should replace the current scattergun clinical use in a multiplicity of poisoning scenarios and subsequent anecdotal reporting approach.
CircABCA13 acts as a miR‐4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1
Authors: Luo Junwen , Tian Zhongxian , Zhou Yongjia , Xiao Zhaohua , Park Sun Young , Sun Hong , Zhuang Ting , Wang Yongjie , Li Peiwei , Zhao Xiaogang
Published: April 2023

Circular RNAs (circRNAs) play a pivotal role in the tumorigenesis and progression of various cancers. However, the role and mechanisms of circABCA13 in esophageal squamous cell carcinoma (ESCC) are largely unknown. Here, we reported that circABCA13, a novel circular RNA generated by back‐splicing of the intron of the ABCA13 gene, is highly expressed in ESCC tumor tissues and cell lines. Upregulation of circABCA13 correlated with TNM stage and a poor prognosis in ESCC patients. While knockdown of circABCA13 in ESCC cells significantly reduced cell proliferation, migration, invasion, and anchorage‐independent growth, overexpression of circABCA13 facilitated tumor growth both in vitro and in vivo. In addition, circABCA13 directly binds to miR‐4429 and sequesters miR‐4429 from its endogenous target, SRXN1 mRNA, which subsequently upregulates SRXN1 and promotes ESCC progression. Consistently, overexpression of miR‐4429 or knockdown of SRXN1 abolished malignant behavior promotion of ESCC results from circABCA13 overexpression in vitro and in vivo. Collectively, our study uncovered the oncogenic role of circABCA13 and its mechanism in ESCC, suggesting that circABCA13 could be a potential therapeutic target and a predictive biomarker for ESCC patients.
Mechanisms responsible for the onset of selective laser flash sintering of 8‐YSZ
Authors: Hagen Deborah , Beaman Joseph J. , Kovar Desiderio
Published: April 2023

Selective laser flash sintering (SLFS) is a variation of flash sintering where the only external heat source is a scanning laser. The scanning laser locally heats a region of the sample between two electrodes, initiating measured current flow at a threshold electric field and laser energy density. This study focuses on understanding how charge transport occurs during stage I SLFS in 8 mol% yttria stabilized zirconia. Two potential charge transport mechanisms are considered: (1) a continuous current moving along a hot line between electrodes and (2) charge transported in a discrete bundle within a hot spot, localized to the area under the laser beam. Two laser scan patterns are employed to experimentally determine how charge is transported during stage I SLFS. Numerical modeling is used to estimate the temperatures at which SLFS initiates, which allows the calculation of charge carrier densities and mobilities relevant for the onset of SLFS. Results demonstrate that both a discrete bundle of charges and continuous flow of charge carriers contribute to the current at the onset of SLFS.
Two and a Half Tales of Europe: How the European Commission Narrates Peoplehood in Migration and Citizenship Policy
Authors: Hase Johanna
Published: April 2023

Since 2019, the European Commission has had a vice president for ‘promoting our European way of life’, but whether a European ‘we’ exists at all is disputed. This article investigates whether and how the Commission has constructed this ‘we’ through narratives of peoplehood. Analysing official communications in migration and citizenship policy between 2007 and 2020, it traces three narrative elements: characters, plot and main theme. The article argues, first, that the Commission's narrative of ‘realizing European citizenship’ creates a sense of peoplehood more than its narrative of ‘achieving a comprehensive migration policy’ and, second, that it has largely repeated its citizenship narrative while adapting its migration narrative. The findings suggest that the Commission is a rather subtle narrator of peoplehood and call into question whether it has a clear idea of the ‘we’ whose ‘way of life’ it seeks to promote.
Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features
Authors: Zanella Simone , Berti Emilio , Bonometti Arturo ,   for Associazione Italiana Ricerca Istiocitosi ONLUS
Published: April 2023

Indeterminate cell histiocytosis (ICH) is a very rare histiocytic disorder, primarily involving the skin. It affects more frequently adults, often presenting with a generalized papular eruption, and needs to be differentiated from other neoplastic, paraneoplastic, and infectious diseases through clinical and histological examination. The knowledge on ICH is limited to case reports and small series. Thus, the lack of larger multicentric studies has prevented recognizing and addressing the specific clinical need of the entity. In this systematic review, we comprehensively analysed the medical literature describing histologically‐confirmed cases of ICH and divided the patients into epidemiologically and clinically different groups. We demonstrate that ICH in adulthood is strongly associated with the development of haematological (and especially myeloid) neoplasms. In this subset of patients, we identify blastic morphology of neoplastic cells as a novel independent prognostic factor and an early histopathological predictor of an associated myeloid neoplasm. Moreover, we highlight that even though ICH may also present in childhood, these patients often show indolent behaviour. Genetically, ICH emerges as a heterogeneous condition. While patients with associated myeloid neoplasms are enriched in pERK pathway gene mutations, in others a specific ETV3::NCOA2 rearrangement is described. We finally reviewe the nosology of ICH since its first description, its possible cell of origin, and summarize the therapeutic options reported for each different clinical subgroup. With this work, we hope to foster studies on rare cutaneous histiocytosis and their comprehensive multidisciplinary characterization.
Characterization of the novel HLA‐A*33 allele, HLA‐A*33:03:55 in a Chinese individual
Authors: Chen Chen , He Yizhen , Dong Lina , Zhang Wei , Zhu Faming
Published: April 2023

Compared with HLA‐A*33:03:01:01, the HLA‐A*33:03:55 allele shows one nucleotide substitution at position 6.
A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum
Authors: Sarathy Jansy P. , Xie Min , Jones Richard M. , Chang Adrienne , Osiecki Paulina , Weiner Danielle , Tsao Wen-Shan , Dougher Maureen , Blanc Landry , Fotouhi Nader , Via Laura E. , Barry Clifton E. , De Vlaminck Iwijn , Sherman David R. , Dartois Véronique A.
Published: April 2023

M. tuberculosis
(Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many
in vitro
models of nonreplicating persistence have been developed to characterize the physiologic and metabolic adaptations of Mtb and identify compounds active against this treatment-recalcitrant population.
Reductive chemistry of pyrrolic macrocycles: A PCET dichotomy between metal and ligand
Authors: Dogutan Dilek K. , Nocera Daniel G.
Published: April 2023

Proton-coupled electron transfer (PCET) is central to the reactivity of porphyrins. The coupling of the electron to the proton is central to a porphyrin’s ability to catalyze energy conversion reactions of which the hydrogen evolution reaction (HER) is exemplary. To understand the mechanistic details of the PCET chemistry of porphyrins and related macrocyclic congeners, we have designed hangman constructs that allow a proton, placed in the secondary coordination sphere (off of the hangman backbone), to be coupled to redox transformations at the macrocycle. For metals whose reduction potentials are positive of the porphyrin macrocycle, such as Co and Fe, HER catalysis is confined to PCET transformations of the metal center where the active catalyst for HER is a reduced metal hydride. Alternatively, the reduction potentials of Ni, Zn, and 2H (freebase) porphyrins allow for redox non-innocence of the macrocycle; here the active “hydridic” catalyst is a phlorin, which gives rise to elaborate HER reaction sequences. Beyond HER catalysis, redox non-innocence of Ni, Zn, and 2H porphyrins and related compounds has been informative for providing detailed mechanistic insight into the multi-site PCET hydrogenation of olefinic bonds of the macrocycle. This mini-review unravels the PCET dichotomy between the metal and macrocycle in promoting HER catalysis and novel chemical transformations that give rise to unusual macrocyclic structures.
Synthesis and characterization of lead metallated non-peripherally substituted octa-octyl tetrabenzo(aza)porphyrins showing face-to-face columnar stacking in the crystal phase
Authors: Vargas Lydia Sosa , Coles Simon J , Tizzard Graham J , Chambrier Isabelle , Cook Michael J , Cammidge Andrew N
Published: April 2023

The full range of porphyrin-phthalocyanine hybrids can be synthesized by treatment of 1,4-dioctylphthalonitrile with varying equivalents of MeMgBr to produce mixtures favoring specific hybrid structures and the tetrabenzoporphyrin in the extreme case. The individual macrocycles can be isolated in pure form as their magnesium derivatives and subsequently demetallated to give the parent metal-free compounds. Insertion of lead proceeded smoothly with all hybrids using lead (II) acetate. In the case of monoaza- and triaza-hybrids, the resulting materials could be recrystallized to give crystals suitable for X-ray diffraction. The crystal structures are distinctive from previously reported examples of non-peripherally substituted octaalkyl phthalocyanines and hybrids (metal-free and metallated, including with lead) and they each present infinite stacks of cofacial macrocycles linked through bridging lead ions which, as expected, lie outside of the macrocycle plane.
Research on the Evolutionary Game Model of Railway Cold Chain Logistics between Cargo Owners and Transport Enterprises
Authors: Zhang Ling , Cao Feng , Wu Yihan
Published: April 2023

The transportation mode of the railway cold chain has an essential impact on operational efficiency and cost. Under the uncertainty of demand and limited transportation capacity, an evolutionary game model of railway cold chain logistics is constructed to explain and analyze the dynamic decision‐making processes and mechanisms between cargo owners and railway transport enterprises. The results show that the evolutionary path and convergence speed of the model are influenced by the initial value and its allocation coefficient, cargo volume, additional benefit, and default cost. By using Matlab, numerical simulation is conducted to verify the theoretical assumptions and results. The conclusion provides a basis for studying and managing railway cold chain logistics.
Data from A Systematic Review and Multilevel Regression Analysis Reveals the Comorbidity Prevalence in Cancer
Authors: Vrinzen Cilla E.J. , Delfgou Linn , Stadhouders Niek , Hermens Rosella P.M.G. , Merkx Matthias A.W. , Bloemendal Haiko J. , Jeurissen Patrick P.T.
Published: April 2023

Abstract
Comorbidities can have major implications for cancer care, as they might impact the timing of cancer diagnosis, compromise optimal care, affect treatment outcomes, and increase healthcare costs. Thus, it is important to comprehensively evaluate cancer comorbidities and examine trends over time. Here, we performed a systematic literature review on the prevalence and types of comorbidities for the five most common forms of cancer. Observational studies from Organisation for Economic Co-operation and Development countries published between 1990 and 2020 in English or Dutch that used routinely collected data from a representative population were included. The search yielded 3,070 articles, of which, 161 were eligible for data analyses. Multilevel analyses were performed to evaluate determinants of variation in comorbidity prevalence and trends over time. The weighted average comorbidity prevalence was 33.4%, and comorbidities were the most common in lung cancer (46.7%) and colorectal cancer (40.0%), followed by prostate cancer (28.5%), melanoma cancer (28.3%), and breast cancer (22.4%). The most common types of comorbidities were hypertension (29.7%), pulmonary diseases (15.9%), and diabetes (13.5%). After adjusting for gender, type of comorbidity index, age, data source (patient records vs. claims), and country, a significant increase in comorbidities of 0.54% per year was observed. Overall, a large and increasing proportion of the oncologic population is dealing with comorbidities, which could be used to inform and adapt treatment options to improve health outcomes and reduce healthcare costs.
Significance:
Comorbidities are frequent and increasing in patients with cancer, emphasizing the importance of exploring optimal ways for uniform comorbidity registration and incorporating comorbidity management into cancer care.
Data from WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth
Authors: Wang Keshan , Ma Fen , Arai Seiji , Wang Yun , Varkaris Andreas , Poluben Larysa , Voznesensky Olga , Xie Fang , Zhang Xiaoping , Yuan Xin , Balk Steven P.
Published: April 2023

Abstract
Noncanonical Wnt signaling by WNT5a has oncogenic and tumor suppressive activities, but downstream pathways mediating these specific effects remain to be fully established. In a subset of prostate cancer organoid culture and xenograft models, inhibition of Wnt synthesis stimulated growth, whereas WNT5a or a WNT5a mimetic peptide (Foxy5) markedly suppressed tumor growth. WNT5a caused a ROR2-dependent decrease in YAP1 activity, which was associated with increased phosphorylation of MST1/2, LATS1, MOB1, and YAP1, indicating Hippo pathway activation. Deletion of MST1/2 abrogated the WNT5a response. WNT5a similarly activated Hippo in ROR2-expressing melanoma cells, whereas WNT5a in ROR2-negative cells suppressed Hippo. This suppression was associated with increased inhibitory phosphorylation of NF2/Merlin that was not observed in ROR2-expressing cells. WNT5a also increased mRNA encoding Hippo pathway components including MST1 and MST2 and was positively correlated with these components in prostate cancer clinical datasets. Conversely, ROR2 and WNT5a expression was stimulated by YAP1, and correlated with increased YAP1 activity in clinical datasets, revealing a WNT5a/ROR2 negative feedback loop to modulate YAP1 activity. Together these findings identify Hippo pathway activation as a mechanism that mediates the tumor suppressive effects of WNT5a and indicate that expression of ROR2 may be a predictive biomarker for responsiveness to WNT5a-mimetic drugs.
Significance:
WNT5a signaling through ROR2 activates the Hippo pathway to downregulate YAP1/TAZ activity and suppress tumor growth, identifying ROR2 as a potential biomarker to identify patients that could benefit from WNT5a-related agents.
Data from SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
Authors: Chambers Courtney , Cermakova Katerina , Chan Yuen San , Kurtz Kristen , Wohlan Katharina , Lewis Andrew Henry , Wang Christiana , Pham Anh , Dejmek Milan , Sala Michal , Loeza Cabrera Mario , Aguilar Rogelio , Nencka Radim , Lacorazza H. Daniel , Rau Rachel E. , Hodges H. Courtney
Published: April 2023

Abstract
In acute myeloid leukemia (AML), SWI/SNF chromatin remodeling complexes sustain leukemic identity by driving high levels of MYC. Previous studies have implicated the hematopoietic transcription factor PU.1 (SPI1) as an important target of SWI/SNF inhibition, but PU.1 is widely regarded to have pioneer-like activity. As a result, many questions have remained regarding the interplay between PU.1 and SWI/SNF in AML as well as normal hematopoiesis. Here we found that PU.1 binds to most of its targets in a SWI/SNF-independent manner and recruits SWI/SNF to promote accessibility for other AML core regulatory factors, including RUNX1, LMO2, and MEIS1. SWI/SNF inhibition in AML cells reduced DNA accessibility and binding of these factors at PU.1 sites and redistributed PU.1 to promoters. Analysis of nontumor hematopoietic cells revealed that similar effects also impair PU.1-dependent B-cell and monocyte populations. Nevertheless, SWI/SNF inhibition induced profound therapeutic response in an immunocompetent AML mouse model as well as in primary human AML samples. In vivo, SWI/SNF inhibition promoted leukemic differentiation and reduced the leukemic stem cell burden in bone marrow but also induced leukopenia. These results reveal a variable therapeutic window for SWI/SNF blockade in AML and highlight important off-tumor effects of such therapies in immunocompetent settings.
Significance:
Disruption of PU.1-directed enhancer programs upon SWI/SNF inhibition causes differentiation of AML cells and induces leukopenia of PU.1-dependent B cells and monocytes, revealing the on- and off-tumor effects of SWI/SNF blockade.
Supplementary Table 1 from Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer
Authors: Fu Maoyong , Maresh Erin L. , Helguera Gustavo F. , Kiyohara Meagan , Qin Yu , Ashki Negin , Daniels-Wells Tracy R. , Aziz Najib , Gordon Lynn K. , Braun Jonathan , Elshimali Yahya , Soslow Robert A. , Penichet Manuel L. , Goodglick Lee , Wadehra Madhuri
Published: April 2023

PDF - 59K, Known Profile of EMP2 Upregulation in Breast Cancer.
Supplementary Figure 2 from Mechanism of Differentiation-Enhanced Photodynamic Therapy for Cancer: Upregulation of Coproporphyrinogen Oxidase by C/EBP Transcription Factors
Authors: Anand Sanjay , Hasan Tayyaba , Maytin Edward V.
Published: April 2023

PDF file - 1071K, C/EBP consensus sites in the human CPO promoter.
Supplementary Figure 1 from Plastin Polymorphisms Predict Gender- and Stage-Specific Colon Cancer Recurrence after Adjuvant Chemotherapy
Authors: Ning Yan , Gerger Armin , Zhang Wu , Hanna Diana L. , Yang Dongyun , Winder Thomas , Wakatsuki Takeru , Labonte Melissa J. , Stintzing Sebastian , Volz Nico , Sunakawa Yu , Stremitzer Stefan , El-Khoueiry Rita , Lenz Heinz-Josef
Published: April 2023

PDF - 278KB, Time-to-tumor recurrence (TTR) by PLS3rs6643869 in female right sided CRC and female left sided CRC patients in USC cohort.