bluuebunny/crossref_metadata_2025 huggingface dataset:
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF DESVENLAFAXINE SUCCINATE BULK DRUG IN ARTIFICIAL URINE
Authors: Bansode A. S. , Shelke V. D. , Gaikwad S. S. ,   Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune - 411 041, Maharashtra, India.
Published: October 2021

Desvenlafaxine (DSV) succinate is a novel serotonin (5HT) and nor-epinephrine reuptake inhibitor (SNRI), which is currently used for the treatment of major depressive disorders and is being studied for use in the management of vasomotor symptoms in postmenopausal women. DSV is a major active metabolite of venlafaxine. DSV has only 30 % of protein binding and approximately 45% of the total oral dose of DSV is excreted unchanged in the urine. The chromatographic separation was performed with acetonitrile and phosphate buffer in the ratio of 25:75 (v/v) at a flow rate of 1 ml/min with UV detection at 224 nm. The extraction was done using C8 solid phase cartridges. The method is validated for precision, linearity, recovery and stability as per the USFDA guideline and the results met the acceptance criteria. The linear regression analysis data for the calibration plots showed a good linear relationship (R2 = 0.995) over a concentration range of 5-30 ppm. The percentage relative standard deviation (% RSD) values of precision were
SYNTHSIS, CHARACTERISATION AND ANTI MICROBIAL EVALUATION OF NOVEL 2-SUBSTITUTED QUINOXALINE DERIVATIVES
Authors: Kamala G. R , Velagaleti A. K. ,   Department of Pharmaceutical Chemistry, Aditya Pharmacy College, Surampalem, Dist-East Godavari - 533 437, Andhra Pradesh, India.
Published: October 2021

literature survey indicates that 2-substituted quinoxaline derivatives possess different pharmacological and biological activities, of which most potent activities are anti-bacterial, anti-fungal, anti-inflammatory, and analgesic activity. In view of above literature, we planned to synthesize novel 2-Substituted quinoxaline derivatives. The final synthesised were characterized by physical (M.P, TLC) and spectral analysis (1HNMR, IR). The 2-substituted quinoxaline nucleus was constructed by condensation of o-phenylene diamine and diethy loxalate in equimolar quantities which upon heating yielded quinoxaline -2, 3-diol moiety. The quinoxaline -2,3-diol was treated with POCl3 to furnish 2,3-di chloro quinoxaline (2). Further the 2-chloro-3-hydrazinoquinoxaline (3) was synthesized by the reaction of 2,3- dichloroquinoxaline (2) and hydrazine hydrate in methanolic medium upon refluxing for 60 min. different Schiff’s bases of 2-chloro-3- hydrazine quinoxaline were obtained by refluxing the appropriate substituted benzaldehyde and 2-chloro-3-hydrazinoquinoxaline (3) in acetic medium for 3 h. All the synthesized compounds were screened for their antibacterial and antifungal activities by using cup plate method against Bacillus subtilis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans at 100, 50 μg/mL concentration using ciprofloxacin and clotrimazole as reference standard drugs respectively. Compounds 4e and 4f showed significant activity against Pseudomonas aeruginosa, 4a and 4d showed significant activity against Bacillus subtilis, the compound 4c showed good activity against the organism Bacillus pumilus, whereas the compound 4a shown moderate antifungal activity against Candida albicans. The rest of the compounds showed weak activity when compared to the standard ciprofloxacin and clotrimazole.
CHEMO PREVENTIVE EFFECT OF PIPERINE IN N-NITROSODIETHYLAMINEINDUCED AND PHENOBARBITAL PROMOTED EXPERIMENTAL RAT HEPATOCELLULAR CARCINOMA
Authors: Yadala P. C , Viswanath Swamy A H M ,   Department of Pharmacology, K.L.E University’s College of Pharmacy, Vidyanagar, Hubli - 580 031, Karnataka, India.
Published: October 2021

Every year, almost 5, 00,000 new patients are diagnosed with hepatocellular carcinoma (HCC), primary malignancy of the liver that is associated with poor prognosis. In recent years, development of efficient anti-cancer agents from natural sources has become a major focus of researchers. The present study was designed to investigate the preventive and therapeutic effects of piperine against DEN induced HCC in male wistar rats. Twenty four rats were divided into four groups (n=6). Group I serves as Control, Group II were induced with HCC by DEN (200mg/kg b.wt) followed by phenobarbital (0.05 % w/V), Group III received same as Group II and followed by piperine (50mg/kg b.wt) and Group IV received piperine alone at a dose of 50mg/kg b.wt, up to 16 successive weeks. Results indicated that there is significant increase in relative liver weight (P<0.001) and liver marker enzymes (SGOT, SGPT, ACP, ALP, LDH, gGT, TBIL, Total protein, DNA at P<0.001), tumor marker enzymes (AFP, CEA at P<0.001). also, significant abnormalities were observed in membrane bound enzymes (Ca2+, Na+/K+, Mg2+ ATP age at P<0.001) and electrolytes (Na+, K+ , Ca2+, Mg2+ at P<0.001), whereas the above said alterations were significantly restored in piperine treated groups compared with DEN treated group. The histopathological changes of liver were compared with respective control groups. These findings suggest that piperine can be used as an adjunct to conventional chemo preventive agent, which may provide a novel therapeutic approach to serve as promising agent for treatment of hepatocellular carcinoma.
ROOM TEMPERATURE SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 2,5-DISUBSTITUTED-1,3,4-OXADIAZOLES
Authors: Somani R. R , Chaskar P. K , Patil P. M. ,   Department of Pharmaceutical Chemistry, Vivekanand Education Society’s College of Pharmacy, Chembur (E), Mumbai – 400 074, Maharashtra, India.
Published: October 2021

One of the principles of green chemistry emphasises on minimisation of environmental and economic impacts by developing synthetic reactions at ambient temperature and pressure.The rise of resistant strains of microorganisms is an issue of regularly expanding seriousness. Therefore, the development of new antimicrobial agents will remain a challenge for chemists. we herein report room temperature synthesis of newer heterocyclic compounds belonging to 1,3,4-oxadiazole scaffold. Their structures were confirmed using various spectroscopic techniques. These compounds were evaluated for antifungal, antibacterial and antitubercular activities.
Toxic Effect of Platinum Compounds: Molecular Mechanisms of Toxicity
Authors: Ali Mayyadah Mahmood , Aziz Tavga Ahmed
Published: October 2021

Despite their effectiveness as a crucial component of combination chemotherapy regimens against solid tumors, platinum compounds have many serious side effects that limit their use. This review article focuses on the various toxic effects of platinum compounds in cancer patients and the mechanisms of toxicity associated with each of these toxic effects. It also describes the future directions for developing novel platinum compounds, using both animal and human studies. The reference lists of relevant publications were included after searching the Google and Google Scholar databases, PubMed, and scientific journals. It focuses primarily on trials that were published between 2005 and 2020. Platinum-based medicines, as a soft nucleophile, can freely bind to peptides and proteins containing sulfur residues from thiol-containing amino acids like cysteine and methionine, as well as the antioxidant peptide glutathione. Platinum medicines, on the other hand, are primarily directed at nuclear DNA. Platinum medicines bind to normal cells as well as malignant cells, particularly those in fast growing tissues, causing a variety of dangerous side effects. Fast-growing tissues such as the mucous membranes of the mouth, throat, stomach, and intestines, bone marrow, and hair follicles can be damaged by cytotoxic chemotherapy drugs, resulting in gastrointestinal toxicities, myelosuppression, and hair loss. Platinum compounds also cause nephrotoxicity and hepatotoxicity, which are well-known side effects. Current platinum-based chemotherapy treatments have been restricted in the last decade, prompting a search for novel platinum-based medications with mechanisms of action distinct from those of existing chemotherapeutics.
The Basic Of Human Resource Management Book 2
Authors:   STIE Jaya Negara Tamansiswa Malang, Widarni Eny Lestari , Bawono Suryaning
Published: October 2021

The Basic Of Human Resource Management Book 2 is the second book in a trilogy of books entitled The Basic Of Human Resource Management Book. Book 2 describes how to manage organizations and people. The explanation in this book is very basic to an understanding of what management is and what is an organization and how to manage an organization.
An Optimization Model for Stock Market Direction Prediction
Authors:   Hefei University of Technology, China, Liu Mingzhong , Metawa N ,   University of Sharjah, Sharjah, United Arab Emirates
Published: October 2021

Stock market direction prediction becomes an essential task in the business sector. The inherent volatile behavior of stock markets worldwide makes the prediction process difficult. The improvement in the prediction accuracy of the stock market direction prediction helps to avoid the risks involved in the investment process. In this aspect, this study designs a swallow swarm optimization (SSO) with a fuzzy support vector machine (FSVM) model for stock market direction prediction. The proposed SSO-FSVM model encompasses preprocessing, feature extraction, FSVM, and SSO based parameter tuning. The usage of the SSO algorithm to fine-tune the parameters involved in the FSVM model helps to significantly improve the overall predictive performance. To validate the improved performance of the SSO-FSVM model, a wide range of experiments were carried out using two benchmark datasets. The experimental outcomes reported the betterment of the SSO-FSVM model over the recent approaches in terms of several evaluation metrics.
Facteurs associés aux cancers de la cavité orale en Afrique Sub-Saharienne : Synthèse de la littérature
Authors: Dieng Amadou , Faye A D , Ndiaye M M , Diop G , Bouazé A , Diouf M
Published: October 2021

INTRODUCTION : Les cancers de la cavité orale constituent aujourd’hui un problème de santé publique selon les données épidémiologiques de l’OMS. Il existe plusieurs facteurs associés aux cancers de la cavité orale mais ils sont variables selon les régions géographiques. L’objectif de ce travail était d’identifier les facteurs associés aux cancers de la cavité orale chez les populations d’Afrique Sub-Saharienne à travers une revue systématique de la littérature. METHODE : A travers les données disponibles de la période de Janvier 1980 à Décembre 2019, une synthèse de la littérature a été réalisée. La stratégie de localisation des écrits comportait une recherche électronique dans les bases de données MEDLINE, EMBASE et GOOGLE SCHOLAR de 1980 à 2019 et une recherche manuelle dans la liste des références des articles identifiés par effet boule de neige. Les données ont été extraites de façon indépendante par deux chercheurs sur un tableur Excel©. Les paramètres recueillis de chaque étude étaient l’auteur, le pays, le type d’étude, la période d’étude, l’effectif, l’âge, le sexe et les facteurs étudiés. RESULTATS : Sur 1.318 articles retrouvés, 24 ont été sélectionnés. Les données contenaient 17.290 patients dont 8.229 hommes soit une sex-ratio 0,91. Les facteurs étudiés étaient le tabac, l’alcool, l’alimentation, l’infection, la génétique et les facteurs sociaux. CONCLUSION : Les résultats rapportés montraient que plusieurs facteurs sont associés à la survenue des cancers de la cavité orale en Afrique Sub-Saharienne. Leur identification et leur contrôle permettraient de réduire la morbidité et mortalité de cette pathologie.
Prise en charge des mélanomes cutanés à l'Institut Joliot Curie de Dakar
Authors: Balegana Jean Claude , Ka Sidy , Diouf Doudou , Thiam Jaafar , Dieng Mamadou Moustapha , Gaye Papa Macoumba , Diop Mamadou , Dem Ahmadou
Published: October 2021

INTRODUCTION : Le but de ce travail est d’étudier les aspects cliniques et thérapeutiques des mélanomes cutanés à l’Institut Joliot Curie de Dakar. PATIENTS ET METHODES : Nous avons réalisé une étude rétrospective, descriptive et critique à l’Institut Joliot Curie de Dakar incluant tous les cas de mélanomes confirmés par l’histologie entre Janvier 2008 et Décembre 2013. RESULTATS : Au cours de la période d'étude, 21 cas ont été pris en charge. La localisation était plantaire dans 76% des cas. Le type acral était retrouvé dans 85,7% des cas. Tous les patients avaient un niveau de Clark supérieur ou égal à IV avec un indice de Breslow supérieur à deux mm. La chirurgie d'exérèse était réalisée chez 14 patients avec curage ganglionnaire inguinale chez 12 patients. La moyenne de suivi était de 16 mois avec une survie globale de 58,7% à six mois et 51% à un an. CONCLUSION : La majorité des patients présentait un mélanome acral et a bénéficié d’un traitement chirurgical, aucune immunothérapie qui à ce jour a révolutionné la prise en charge des mélanomes avancés n’a été administrée.
Profil des cancers de la parotide à la clinique ORL Lamine Sine Diop du CHU de Fann
Authors: Dièye Abdoulaye , Younès H , Ndiaye C , Ahmed H , Yassine L , Loum B , Ndiaye M , Ndiaye I C
Published: October 2021

INTRODUCTION : Les cancers de la parotide sont caractérisés par une grande diversité histologique et ils posent des problèmes diagnostiques, thérapeutiques et évolutifs. Nous livrons à travers cette étude notre expérience sur la prise en charge des tumeurs malignes de la parotide. MATERIELS ET METHODES : Il s’agit d’une étude rétrospective, descriptive et analytique réalisée sur une période de 12 ans dans le service d'ORL du CHNU de Fann. RESULTATS : L’âge moyen au moment du diagnostic était de 48 ans avec un sex-ratio de 1,6. La durée d’évolution des symptômes était d’environ de 47 mois. La tuméfaction parotidienne était présente chez tous les patients et une paralysie faciale périphérique était retrouvée chez 31% des patients. L'échographie de la région parotidienne a été réalisée chez 11 patients, soit 34% et la tomodensitométrie chez 18 patients, soit 56%. La cytoponction était effectuée chez 11 patients. Les cancers parotidiens représentaient 44% de l'ensemble des tumeurs parotidiennes. Soixante-huit pour cent des patients ont consulté au stade de T4. Soixante-onze pourcent des patients ont bénéficié d'un traitement chirurgical. Le type histologique le plus fréquent était le carcinome muco-épidermoïde. Cinq patients ont bénéficié de radiothérapie. Les suites opératoires ont été dominées par la PFP (18%). Sept cas de décès ont été enregistrés. CONCLUSION : Le profil des cancers de la parotide est caractérisé par l’âge jeune, le stade avancé au diagnostic et l’absence de traitement adapté caractérisé en dehors de la chirurgie par la rareté de la radiothérapie et de la chimiothérapie.
Carcinome indifférencié du nasopharynx associé à une dermatomyosite paranéoplasique à un stade précoce T1N0M0 : A propos d’un cas et revue de la littérature
Authors: Panandtigri S , Charkaoui M , Sia N P X , Benchakroun N , Tarek C , Bourhafour M , Bouchbika Z , Jouhadi H , Tawfiq N , Saharaoui S , Benider A
Published: October 2021

La dermatomyosite (DM) est une maladie auto-immune rare, caractérisée par une atteinte inflammatoire non infectieuse de la peau et des muscles prédominants aux ceintures. Elle serait associée à environ un cas sur 1.000 au carcinome nasopharyngé (NPC). Cette association a été décrite pour les stades localement avancés, stade II et stade III du NPC. Peu décrite à des stades précoces (stade I), sa symptomatologie est souvent révélatrice du cancer dont le diagnostic repose sur cinq critères : la faiblesse musculaire des membres proximaux, l’élévation des enzymes musculaires sériques, les anomalies musculaires histologiques à la biopsie musculaire, l’anomalie électromyographique et la manifestation dermatologique inflammatoire clinique. Le traitement repose sur la corticothérapie et le traitement étiologique du cancer. Le pronostic des NPC chez les patients atteints de DM paranéoplasique est comparable aux patients non atteints. Nous rapportons ce cas de DM révélant un NPC à un stade précoce et nous faisons le point sur l’état des connaissances sur la DM paranéoplasique associée à un NPC rarement décrite. En effet, au Maroc la dernière description d’un cas remonte en 2016.
MELACAK PERAN AGAMA DALAM RUANG PUBLIK
Authors: Gora Redemptus B.
Published: October 2021

Pemikiran Jurgen Habermas tentang masyarakat postsekular harus dimengerti juga dalam kaitannya dengan kebangkitan agama. Dalam masyarakat sekular, lewat proses modernisasi, agama didomestifikasi. Kini dalam zaman postsekular agama bukannya lenyap, sebaliknya justeru menunjukkan potensi semantiknya. Melihat peristiwa itu, Jurgen Habermas meyakini bahwa peran agama dalam ruang publik suatu negara hukum demokratis perlu diperhitungkan. Agama tidak cukup dipandang sebagai artefak kebudayaan yang usang. Penulis berusaha menguraikan bagaimana Habermas menimbang eksistensi dan peran agama itu dalam ruang publik
PENDIDIKAN TENAGA PASTORAL YANG INTEGRAL DAN KONTEKSTUAL DI INDONESIA
Authors: Gunawan Leo Agung Srie , Sihombing Kaisar Octavianus
Published: October 2021

As Christians, it is our duty to tell the world the truth. The truth is not totally an abstract concept. By the existence of Jesus in time and space, we are able to know God himself empirically according to our sensibilities as human being. In short, proclaiming Jesusâ€™ life is proclaiming the truth itself. Nowadays, this duty requires more effort in order to spread the spirituality of Jesus to more people. Progressive development in many ways and stuff bring more obstacles than before. Those who involve themselves in ecclesiastical services should improve their skills due to many challenges among plethora misleading teaching and misconception about what the truth is. In this case, church takes important part in educating and formatting certain people â€“ they could be either priests, religious men or women, or lay people â€“ through its ecclesiastical studies. As for progress, there are at least four fundamental elements we should to care about in order to build better and updated ecclesiastical education.
REKONSILIASI KOSMOLOGIS Antara Teorema Penciptaan dan Teori Evolusi
Authors: Gunawan Leo Agung Srie
Published: October 2021

The problem of the universe having a great mystery encloses the big question about its origin. To answer the origin of universe, generally, there are two approaches, namely faith and science. The main question has to be replied: â€œWhat do the differences and the similarity of them?â€ The approach of faith bases on the inquiry of â€œwho causes the existence of the universeâ€. This approach states that the origin of universe was created by God and hence, it was formed by God from a nothingness (creatio ex nihilo). This is known as the theorem of creation. Furthermore, the scientific approach is grounded on the research of â€œhow the universe was formed in the beginningâ€. This oncoming being explained by the Big Bang Theory, which is continued by the Big Crunch Theory, asserts that the origin of universe came from the prime matter which exploded incredibly in a such a way that the formation process of the universe took place (the singularity). This is well-known as the theory of evolution (the cosmological evolution). In conclusion, the scientific approach explaining the process of creation and the faith one answering the actor of it are complementary.
AMANAH AGUNG TUHAN YESUS DALAM KEEMPAT INJIL DAN IMPLIKASINYA DALAM MEMAHAMI INJIL, BUDAYA DAN PEWARTA INJIL
Authors: Wardoyo Gregorius Tri
Published: October 2021

Injil Matius 28:16-20 kerap kali dijadikan dasar misi murid-murid Yesus di dunia ini. Ada bahaya misi disempitkan pada tindakan membaptis saja. Melalui studi intertekstual yakni dengan membandingkan Injil Matius dengan ketiga Injil lainnya, ditemukan bahwa misi tidak sekadar tindakan Â membaptis Â tetapi lebih-lebihÂ  mewartakan Â Injil yangÂ  berisi Â bahwa AllahÂ  senantiasa menyertai umat manusia dan bahwa Allah yang sama menawarkan kepada umat manusia pertobatan dan pengampunan dosa dari Allah. Inilah kabar sukacita yang hendaknya diwartakan oleh pewarta Injil dalam budaya dimana mereka hidup.
BERPARTISIPASI AKTIF BERINTERKULTURASI DI KENISCAYAAN MULTI KULTUR : Implementasi Ratio Formationis Ordinis Fratrum Capocinorum di Indonesia
Authors: Nadeak Largus
Published: October 2021

Kemajuan teknologi komunikasi memudahkan manusia untuk mengenal satu bumi serta memelihara keragaman budaya dan agama yang ada di dalamnya agar kebersamaan bersaudara hidup dalam damai. Keragaman budaya (multikultur) sangat khas di Negara Kesatuan Republik Indonesia. Keniscayaan multikultur bisa menjadi ancaman kebersamaan kalau ada kelompok primordial sempit dan kelompok radikalisme destruktif yang ingin mengkoloni satu budaya dan masyarakat penghayatnya demi kepentingan politis dan kuasa. Sebaliknya keniscayaan multikultur akan menjadi rahmat indah â€œbepelangiâ€ kalau masyarakat berpartisipasi aktif berinterkulturasi. Budaya perjumpaan akan bertumbuh sehingga setiap budaya memiliki jati nilai dan masyarakat penghayatnya memiliki jati diri. Ordo Kapusin penyebar kharisma persaudaraan dengan kesadaran tinggi mengajak semua saudara untuk aktif berpartisipasi berinterkulturasi secara internasional dan terutama secara nasional dan lokal. Usaha berinterkulturasi diwajibkan untuk dijabarkan dalam kurikulum dan program pendidikan di setiap daerah agar para saudara menjadi berkharisma dengan menggali kearifan lokal yang bersintese dengan nilai universal yang dihayati dan diserukan oleh Fransiskus dari Assisi penghayat Injil Tuhan Yesus Kristus.
Factors Influencing the Usage of Instagram for Business and its Effect on Financial Performance and Non-Financial Performance
Authors:   Department of Management, University of Aveiro, Portugal,, Akbar Altaf
Published: October 2021

The objective of this article is to study the factors which affect the Small and Medium Enterprises (SMEs) instagram use for business and its subsequent impact on financial and non-financial performance. The primary purpose of this study is to examine the effect of competency, cost-effectiveness, innovative behavior, and interactivity on instagram use for business, and consequences on firms' performance. Statistical analysis was performed on the data acquired through a survey questionnaire from 352 Malaysian SME employees. The findings revealed that competency, cost-effectiveness, innovative behavior, and interactivity have a positive influence on instagram use for business. The results also indicated that instagram use for business has a strong positive effect on the financial performance and non-financial performance of SMEs. All the hypotheses were accepted and tested by a partial least square (PLS) approach.
Internal Factor of Systemamtic Risk Model With Information Technology As Intervening Variables to Increasing Quality of Government Financial Reports In Indonesia: Actual Case From Riau Island Province
Authors: Riyadi Am. , Khaddafi Muammar , F Fuadi , F Falahuddin , Nur Ilham Rico
Published: October 2021

For the realization of the vision and mission of the Riau Islands Provincial Government, improving the competence of human resources in employees is an important aspect. Human Resources is the most important asset in the company. However, in practice it is not easy for organizations to make HR as a useful asset. Organizations need to implement a competency-based HR system to eliminate conflicts between organizations and employees, because in modern management philosophy, employees are human beings who have needs, expectations that need to be heard along with potential and competencies that can be developed to achieve organizational performance and performance. The purpose of this study was to determine the direct and indirect effect of the variable competence of human resources, job relevant information and financial planning on the quality of financial reports as well as through information technology. This study uses primary data derived from questionnaires and secondary data obtained from books and related literature. The data analysis technique uses the SEM version 3.0 tool. As for the results of this study, there is a direct influence of the Financial Planning variable on the Information Technology variable having a positive path coefficient. The direct influence of the Financial Planning variable on the Financial Statement Quality variable has a positive path coefficient. The direct influence of the Information Technology variable on the Financial Statement Quality variable has a path coefficient of positive. The direct influence of the Human Resources Competency variable on the Information Technology variable has a positive path coefficient. The direct influence of the Human Resources Competency variable on the Financial Statement Quality variable has a positive path coefficient. Variable direct effect Job Relevant Information on Information Technology variables has a path coefficient of positive. The direct influence of the Job Relevant Information variable on the Financial Statement Quality variable has a positive path coefficient.
Relationship Between Budget Participation, Job Characteristics, Emotional Intelligence and Work Motivation As Mediator Variables to Strengthening User Power Performance: An Emperical Evidence From Indonesia Government
Authors: Sandi Heri , Afni Yunita Nur , Heikal Mohd. , Nur Ilham Rico , Sinta Irada
Published: October 2021

In this study, researchers used respondent data, such as gender, age and length of employment of respondents in order to provide information about the characteristics of respondents. Where from the questionnaires distributed as many as 186. The discussion in this chapter is the result of field studies to obtain data on answers to questionnaires that measure the five main variables in this study, namely  budget participation, job characteristics, emotional intelligence, work motivation and power performance of budget users. Data analysis with parametric and non-parametric statistics using SEM-PLS (Structural Equation Modeling-Partial Least Square) regarding research variables, instrument testing, normality testing, hypothesis testing, and discussion of the results of hypothesis testing and Path Analysis. The effect of the X3 variable on X4 has a P-Values ​​value of 0.000 <0.05, so it can be stated that the effect of X3 on X4 is significant. The effect of the X3 variable on Y has a P-Values ​​value of 0.000 <0.05, so it can be stated that the effect of X3 on Y is significant. The effect of the X4 variable on Y has a P-Values ​​value of 0.213 <0.05, so it can be stated that the effect of X4 on Y is significant. The effect of the X1 variable on X4 has a P-Values ​​value of 0.066 > 0.05, so it can be stated that the effect of X1 on X4 is not significant. The effect of the X1 variable on Y has a P-Values ​​of 0.481 > 0.05, so it can be stated that the effect of X1 on Y is not significant. The effect of the X2 variable on X4 has a P-Values ​​value of 0.251 > 0.05, so it can be stated that the effect of X2 on X4 is not significant. The effect of the X2 variable on Y has a P-Values ​​value of 0.124 > 0.05, so it can be stated that the effect of X2 on Y is not significant.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI STRUKTUR MODAL PADA CV BENGKEL BUNGA HARAPAN DI KABUPATEN BERAU
Authors: Sayugo Adi Purwanto
Published: October 2021

Determination of capital structure is very important for companies and parties outside the company such as creditors and investors because it is very basic and has a long-term impact. One important consideration that must be considered carefully before determining the company's capital structure is the consideration of the amount of capital costs from all funds / capital used by the company. In determining the capital structure must be able to reflect the balance or comparison between foreign capital and own capital that is best in a company influenced by many factors, including: asset structure and earning stability.

CV Bunga Harapan Workshop in Berau District in the face of tight business competition must be able to establish an optimal capital structure. This is because the capital structure is an important problem for every company, because the good and bad capital structure will have a direct effect on the company's financial position. The initial observation shows CV Bunga Harapan Workshop in Berau District does not understand the problem of the capital structure.The purpose of this study was to determine the effect of asset structure and earnings stability on the capital structure on CV Harapan Bunga Workshop in Berau District. Data analysis tools used were normality test, multicollinearity test, autocorrelation test, multiple linear regression analysis, determination coefficient, t test and F test.

The results of this study conclude that the structure of assets and earnings stability have a significant effect on the capital structure of CV Bunga Harapan Workshop in Berau District. This is evidenced by the results of the F test where F-count is greater than F-table (21.115> 4.74) and significant value 0.001 <0.05. The asset structure has a significant effect on the capital structure at CV Bunga Harapan Workshop in Berau District. This is evidenced by the results of the t test where -t count is smaller than -t-table (-3,078 <-2,365) and significant value (0,000) smaller than 0,05. Earning stability has a significant effect on the capital structure at CV Bunga Harapan Workshop in Berau District. This is evidenced by the results of the t test where t-count is greater than t-table (2.975> 2.365) and a significant value (0.021) which is smaller than 0.05.
Peranan Badan Usaha Milik Desa (Bumdes) Pada Kesejahteraan Masyarakat Pedesaan ( Studi Kasus Pada Bumdes Di Kabupaten Mempawah, Kalimantan Barat).
Authors: Sunaryono
Published: October 2021

This study aims to analyze the existence of Village-Owned Enterprises (BUMDes) on community welfare. This research uses the Community Based Research method, which consists of 3 stages including: a. indepth interview stage with participants who are key actors in BUMDes, b. the stage of group discussion based on the interest groups in the village, and c. the FGD (Focus Group Discussion) phase where the discussion is carried out by all interested parties. All this was done to validate and verify the findings in the previous stage. The results of this study indicate the presence of BUMDes has had an impact on changes in the economic and social fields of rural communities. Although it has not been able to provide significant benefits for improving the welfare of villagers directly, it has slowly been able to provide solutions to several problems, especially related to the marketing of superior products and employment.
Perspektif Etika Bisnis Mahasiswa Terhadap Penggunaan Software Asli Dan Bajakan Di Kotamadya Pontianak
Authors: Hijrah Wahyudi  , Mardiyati Mardiyati
Published: October 2021

The purpose of this research is to know the college student’s perspective of business ethic about genuine software fake software; to socialise and disseminate some freewaresto the college students. This analysis is done by using descriptive analysis in order to answer the research. This research is done to 100 college students ( 50 persons from STIE Indonesia Pontianak, and 50 persons from STIE Pontianak). Result of the research concludes that happened gap, in which the perspective of business ethic is above the piracy of the software. .
ANALISA PENGARUH KUALITAS PRODUK DAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN YAMAHA MIO DI TELUKJAMBE KARAWANG BARAT
Authors: Ajat Sudrajat  , Muhammad Fauzan Habibie  , Rudy Ramadhan
Published: October 2021

One's buying behavior towards a product purchases a lotfactor. Everyone has different desires and tastes.Product quality is a crucial factor in the decisionpurchase, besides that there are still many other factors that influence behaviorthe purchase.This research is to analyze the effect of product quality,promotion of purchasing decisions for Yamaha motorcycle productsAlso analyze the variables that have the most dominant influenceon the decision to purchase Yamaha Mio motorcycle products to the publicin the Teluk Jambe region.The population in this study is motorcycle consumersYamaha Mio in the Surakarta region. The sample used was 100respondents with the Accidental Quota Sampling technique. Data collection techniqueswith a questionnaire, while the data analysis technique uses regression analysismultiple linear, classic assumptions (normality test, multicollinearity test, testheteroscedasticity), statistical tests (t test, F test and coefficient of determination).From the results of the analysis of classical assumptions, normality test with kolmogorovsmirnovObtained significantly greater than 0.05, which means the data distributionnormal. Multicollinearity test obtained by the value of VIF and Tolerance obtainedone regression model can be canceledmulticollinearity, while the heteroscedasticity test using the Glejser methoddeclare no problem.Based on the results of multiple linear regression analysis of the t test obtainedProduct quality is significant todecision to purchase Yamaha Mio motorcycle products, while the promotion andsignificant significance at 5% tarap. From the test resultssimultaneous influence of product quality, promotiondecision to purchase a Yamaha Mio motorcycle product where the calculated F value> Ftable. The most dominant product qualitypurchase of Yamaha Mio motorcycle products. Obtained an R square value of0.255, which means that the dependent variable can be understood by the independent variableof 25.5% while the remaining 74.5% is approved by other variables
KARAKTERISTIK, HAMBATAN-HAMBATAN DAN FAKTOR-FAKTOR YANG MEMPENGARUHI PRODUKSI USAHA KECIL MENENGAH (Studi kasus UKM Batik Tulis Trusmi di Desa Trusmi Wetan dan Kulon Kecamatan Plered Kabupaten Cirebon)
Authors: Suripto Suripto  , Iman Krismanto
Published: October 2021

This study discusses the characteristics, constraints and factors of production of Trusmi written batik SMEs in Trusmi Wetan and Trusmi Kulon Villages, Plered District, Cirebon Regency. The objectives of this study are: (1) analyzing the characteristics of Trusmi handmade batik seen from business owners, the output/products produced and marketing, (2) analyzing the difficulties/obstacles experienced by Trusmi handmade batik UKM, (3) analyzing the influence of factors -factors of production against the amount of batik production Trusmi. This study uses statistical analysis tools both descriptive and inferential. Descriptive analysis is used to determine the characteristics, difficulties and obstacles experienced by SMEs in batik writing. Multiple linear regression is used to determine the effect of variable raw materials, wages, labour, education and business experience on the amount of Trusmi written batik production in Trusmi Wetan and Kulon villages, Plered District, Cirebon Regency. The results showed that (1) the characteristics of owners/entrepreneurs of Batik Tulis Trusmi as many as 15 (50%) craftsmen started their business background from generation to generation/inheritance and as many as 15 (50%) the rest were independent business backgrounds. The level of craftsman education is dominated by high school and the average age of the craftsman is 51 years. Products produced by craftsmen in the form of hem/shirt, sarong, shawl and marimbist in their marketing crafters supply several showrooms in Trusmi and are sent to several regions, (2) batik artisans experience difficulties and obstacles in terms of capital, raw materials and human resources, (3 ) multiple linear regression using individual test (t-test) shows that raw materials and wages have a positive and significant effect on the amount of batik production, while the amount of labour, education and business experience does not affectt
ANALISIS PENGARUH CR DAN ROE TERHADAP PER PADA PT. INDOFOOD SUKSES MAKMUR TBK TAHUN 2011-2018
Authors: Firanti Hardianti  , Sukma Febrianti
Published: October 2021

PER is an important ratio in analyzing stocks, research was conducted at PT. Indofood Sukses Makmur Tbk by using two ratios as analysis tools, namely CR and ROE. The author chooses to conduct research at PT. Indofood Sukses Makmur Tbk because it is the largest consumer food company compared to its peers in Indonesia. This research was conducted to see the effect of CR and ROE simultaneously, partially and dominantly on PER using quantitative descriptive methods. The results showed that the data used were normal using the normal probability test plot. If using multiple linear regression test, the CR has a unidirectional relationship, while the ROE is not in the same direction as the PER. The results of hypothesis testing using the F test and t test. The F test states that the CR and ROE have a simultaneous effect and the t test partially affects the PER. To see how much influence the independent variable has on the dependent variable, a determination coefficient test is carried out with the result that the independent variable is quite influential on the dependent variable by 79.5%, and finally the dominant test with the results of ROE which has the most influence on the PER
PREDIKSI FINANCIAL DISTRESS PADA PT. BANK RAKYAT INDONESIA (Persero) TBK. SEBELUM DAN SEMASA PANDEMI COVID-19
Authors: Didi Rahmat
Published: October 2021

This study aims to see how the financial performance of PT. Bank Rakyat Indonesia (Persero) Tbk. studied from the Financial Distress approach. The data taken is from the period 2017 to 2019 (normal period) and 2020 (the period of the Covid-19 pandemic in Indonesia). Altman Z Score is used as an approach in data analysis by using five indicators, Working capital to total assets (WCTA), Retained earnings to total assets (RETA), Earnings before interest and taxes to total assets (EBITTA), Market Value of equity / Book value of debt (MVEBVD) and Sales / total assets (SATA). From the results of data analysis, it was found that before the Covid-19 pandemic the company was classified as healthy. Changes occurred during the Pandemic the company was in the Gray Area which meant there were financial problems.
PERAN KOMPENSASI FINANSIAL DAN KOMPENSASI NON FINANSIAL DALAM MENINGKATKAN PRODUKTIVITAS KERJA PEGAWAI NEGERI SIPIL PADA DINAS SOSIAL KOTA BANJARMASIN
Authors: Khairunnisa Khairunnisa
Published: October 2021

Research purposes for knowing role financial and non financial compensations in upgrade work productivity of Pegawai Negeri Sipil on Dinas Sosial Kota Banjarmasin. Component of compensation consists of salary, wage, incentive and fringe benefit. Population in this research amount 35 peoples and sample 20 peoples. Explenation tittle among them, compensation is all income being of money, direct goods or undirect receive of employes are reward or service given to agency. Work productivity is ratio between result achieved with role participation of labour unity of time. Dinas Sosial Kota Banjarmasin is agency of government to manage matter society, as help social to disaster, religion, etc.
ANALISIS KINERJA PT MATAHARI DEPARTMENT STORETBK PASKA DIMULAINYA PANDEMI COVID-19
Authors: Sunaryono Sunaryono
Published: October 2021

This research aims to determine the financial performance of PT Matahari Department Store Tbk before and after the Covid-19 pandemic was started so that it can be observed the increase or decrease after the Covid-19 pandemic was started. The data used are the financial statements of the posted-Pandemi Covid-19 of PT Matahari Department Store Tbk before the covid-19pandemicwas started in the January-December 2019 and after the covid-19 pandemic was started in the January - December 2020 period. Data analysis using Du Pont System Analysis. The results showed an increase in the financial ratios before the covid-19 pandemic started and after the covid-19 pandemic started. This is indicated by the achievement of an increase in the percentage of Return on Investment, Return on Assets, Cash Ratio, Current Ratio, Collection Period, Inventory Turn Over, Total Asset Turn Over, and Total Equity so that the increase can prove that the research hypothesis proposed that after a covid-19 pandemic is proven to experience efficiency and decrease its financial performance.
ANALISIS BENEISH M-SCORE UNTUK MENDETEKSI FINANCIAL STATEMENT FRAUD PADA PT. GARUDA INDONESIA Tbk PERIODE 2017-2019
Authors: Dedi Julianto  , Marjono Marjono  , Aminullah Labangge
Published: October 2021

This study aims to detect financial statement fraud at PT. Garuda Indonesia in 2017-2019 used the Beneish M Score model and testing whether the Beneish M Score model can detect the occurrence of financial statement fraud at PT. Garuda Indonesia in 2018. The results of this study indicate that PT Garuda Indonesia was classified in the Gray criteria, that can be interpreted as manipulate or not manipule financial statements in 2017 and 2018 and classified in the criteria not manipulate financial statements in 2019. The results of this study also found that the Beneish M Score model could not accurately to detect the manipulation of financial statements at PT. Garuda Indonesia in 2018, because only two ratios are Gross Margin Index (GMI) and Days Sales in Receivable Index (DSRI) which detect manipulation of financial statements, so they are only classified in the gray area criteria
ANALISIS PENERAPAN STRATEGI BERTAHAN PIZZA HUT INDONESIA & KONDISI LABA PERIODE BERJALAN SELAMA PANDEMI COVID-19
Authors: Hijrah Wahyudi  , Mardiyati Mardiyati
Published: October 2021

This research is expected to be useful for stakeholders both theoretically and practically in terms of choosing and implementing a survival strategy in order to save the company, especially in times of crisis. To answer the research questions, qualitative data analysis techniques were used which followed the following three stages:

Data analysis, drawing conclusions and verification  and narrative of analysis results. It can be concluded that the defensive strategy undertaken by PT Sarimelati Kencana, Tbk in the face of the Covid-19 pandemic is appropriate, because it is proven that this strategy can still print positive sales, stable cost of goods sold, positive gross profit, still operating profit positive, and stable operating expenses. However, interest and financial expenses that exceed operating profit are the cause of losses for the franchise holder of the Pizza Hut Indonesia restaurant.From this research, it can be suggested for business people in general to consider and pay careful attention to plans or debt decisions. If the business actor is already in debt, then strengthen the intention and determination to immediately pay off these debts. Good products, good product selling prices, effective promotions, strategic selling locations, and increased sales volume will be in vain when business actors are faced with debt interest expenses that exceed operating profit.
Teaching Research Writing to Chinese Graduate Students: A Guided Discovery Genre Approach
Authors: Guo Hua
Published: October 2021

One of the biggest challenges graduate-level research writing instructors face is how to motivate students in large and multidisciplinary classes effectively. This article explores the influence of a guided inductive and discovery-based genre approach on improving students’ knowledge of research writing. A questionnaire survey was conducted, and some of the students’ written assignments were analyzed. The survey results show that the students were generally satisfied with this approach and affirmed its effectiveness in increasing their knowledge of the textual organization, format and documentation, and language style in research writing. Examining the students’ written analysis of the move structure of abstracts indicates that this approach has enhanced the students’ ability to identify moves and facilitated their acquisition of more appropriate genre knowledge. Further examination of the students’ written reflections reveals a more in-depth understanding of their learning experience. Implications and directions for future research are discussed.
De licht verstandelijk beperkte verdachte in het gemoderniseerde strafproces
Authors: Lagerweij Rosanne , Middelkoop Heleen
Published: October 2021

Suspects with a Mild Intellectual Disability in the modernized Dutch criminal proceeding

Suspects with a Mild Intellectual Disability (hereafter: MID) are over-represented in the criminal justice system. Is the right to a fair trial of these vulnerable suspects sufficiently guaranteed in the modernized Dutch Code of Criminal Procedure? To this end, it is first of all important that the MID is recognized by legal professionals in the criminal justice system. In this way, the suspect with an MID can be treated and interrogated in the right way, which can, for example, prevent making a false statement. Secondly, it is important that the compensatory and remedial measures that professionals may take according to the modernization are clarified. The professionals should know in which phase of the criminal proceeding they should apply certain measures. Finally, the question arises whether the addition of a lawyer is the most important measure to compensate the suspect with an MID for his disability.
Een motief om te motiveren? Het helpt!
Authors: Elffers Henk , Ernst Eline , Klijn Albert
Published: October 2021

Why should criminal judges motivate their verdict better? – Simply, it does increase laypeople’s understanding

Does a better quality of arguing by a criminal judge why he/she metes out a certain punishment enhance the public’s understanding and endorsement of criminal verdicts? A sample of 235 Dutchmen got presented two verdicts in a within person design, one with a well motivated meting out of punishment, one with a defective motivation. Subjects reported on understanding and endorsement. Better motivated verdicts turn out to be better understood and are more endorsed.
Evaluatie pilot geïntegreerde aanpak huiselijk geweld
Authors: Bruning Mariëlle , Buysse Wendy , Piepers Nynke
Published: October 2021

Evaluation pilot integrated approach to domestic violence – Lessons to be learned?

In the Netherlands, domestic violence cases are often heard in criminal court by a single judge. In these cases usually the family is usually confronted with multiple problems related to divorce or separation, child protection issues, financial problems, psychological problems or addiction and aggression problems that can lead to various legal proceedings with different judges. The District Court of Rotterdam has started a pilot ‘integrated approach to domestic violence’. In this paper results of the pilot evaluation are presented in relation to recent developments of the judiciary to focus on effective problem solving courts.
Chinese Herbal Medicine-Induced Rapid Liver Cirrhosis: A Case Report
Authors: Cao Ruijie , Zhang Shasha , Li Jing , Zhang Jingjing , Zhao Yufei , Jiao Pengqing , Wang Cuiju , Guo Zhanjun
Published: October 2021

Introduction: Chinese herbal medicine (CHM) has been widely used by patients in China and results in unpredictable nephrotoxicity and hepatotoxicity effects. Case Presentation: We report the case of a postoperative 69-year-old female patient with ascending colon cancer who rapidly developed liver cirrhosis after 18 months of continued CHM administration. The patient underwent right hemicolectomy at the Fourth Hospital of Hebei Medical University in August 2019 due to ascending colon cancer; at that time, the patient had no signs of liver cirrhosis based on computed tomography (CT) and routine blood examination. Postoperatively, the patient continued CHM administration for 18 months. The patient then visited our hospital with complaints of jaundice, abdominal distension, and edema in both lower limbs. CT imaging showed cirrhosis of the liver, while gastroscopy showed mild esophageal varices. Blood examinations including routine blood, coagulation function, and liver function tests, and biomarkers of hepatic fibrosis also supported the diagnosis of liver cirrhosis. To the best of our knowledge, this is the first report of CHM-induced liver cirrhosis. Conclusions: CHM administration possibly induces rapid liver cirrhosis within 18 months.