bluuebunny/crossref_metadata_2025 huggingface dataset:
TACTICAL IMPLEMENTATION OF THE REDUCTION STRATEGY IN THE ELECTION DEBATES OF H. CLINTON AND D. TRUMP
Authors:   Mykhailo Tuhan-Baranovskyi Donetsk National University of Economics and Trade, Herasymenko O. Yu.
Published: July 2023

Objective. The objective of the present article is to analyze the materials of the pre-election debates of H. Clinton and D. Trump in order to study the tactical implementation of the strategy of reduction as an effective means of manipulative influence. Methods. The main scientific results are obtained using a set of general and special research methods, namely: analysis of video and audio materials of election debates, comparison, synthesis, systematization and generalization of scientific literature. Results. Discourse is one of the most important categories of communication that reflects speech interaction. The subject of special scientific interest in our study is political discourse, in which one of the leading roles is played by manipulative influence on the audience by choosing appropriate tactics, strategies and language tools. The texts of the election speeches of the presidential candidates Hillary Clinton and Donald Trump were chosen as illustrative material for the study of manipulative influence strategies. In our study, we rely on the classification of strategies and tactics of manipulative influence, which was proposed by researcher O. Mikhaleva, because this classification allows us to comprehensively consider the main strategies used in political discourse and, consequently, to achieve their goals. In particular, the researcher singles out the strategy of reduction, strategy of increase, strategy of theatricality. In our article, we looked in detail and analyzed the use of American politicians to reduce the strategy. It is established that both candidates actively use the strategy of reduction, which is implemented through appropriate tactics. The strategy for reduction is represented by such tactics as analysis — “minus”, discrediting the opponent, impersonal accusation, exposure, insults, threats.
PROBLEMS OF INTERNALLY DISPLACED PERSONS EMPLOYMENT IN UKRAINE
Authors:   Mykhailo Tuhan-Baranovskyi Donetsk National University of Economics and Trade, Shulzhenko I. V.
Published: July 2023

Objective. The objective of the research is solving the problems of employment of internally displaced persons by providing them with certain benefits and advantages in labour relations. Methods. The tasks are solved by using such methods as analysis and generalization of scientific, popular science literature and regulations that provide information connected with benefits and advantages to employees of enterprises that have the status of internally displaced persons. Results. The author analyzes the benefits and advantages provided to internally displaced persons in the field of employment at the new place of registration in Ukraine, as well as provides proposals for improving the legal protection of internally displaced persons. The author offers to make the following changes and additions to the current legislation of Ukraine. First, to supplement Art. 42-1 of the Labour Code with the following rule: “An employee who was forced to resign and has the status of an internally displaced person has the pre-emptive right to conclude an employment contract in case of return employment when Ukraine regains control over the territory where such an employee works”. Secondly, to supplement Art. 7 of the Law of Ukraine «On Ensuring the Rights and Freedoms of Internally Displaced Persons» of 20.10.2014 № 1706-VII norm of the following content: «it is prohibited to refuse internally displaced persons employment and reduce their salaries for reasons related to status of internally displaced person. In case of refusal to hire an internally displaced person, the owner or his authorized body is obliged to inform him of the reasons for refusal in writing. Refusal to hire can be appealed in court».
INFORMATION AND COMMUNICATION TECHNOLOGIES INFLUENCE ON THE TOURISM SPECIALIST’S PROFESSIONAL COMPETENCE FORMATION
Authors:   Mykhailo Tuhan-Baranovskyi Donetsk National University of Economics and Trade, Bohatyryova G. A.
Published: July 2023

Objective. The article is devoted to the study of the influence of information and communication technologies on the formation of professional competence of specialists in the field of tourism. The author studies the conditions under which the tourism market’s need for specialists who possess a high level of professional competence, professional mobility, and the ability to adapt to the conditions of professional activity through the use of information and communication technologies (ICT) will be solved. The need for a systematic approach to the problem is substantiated through the development of a structural-functional model of the process of formation of professional competence of specialists in the field of tourism by means of information and communication technologies. Methods. The main research methods of the process of formation of professional competence by means of information and communication technologies are: the abstract-logical method for determining the main problematic issues of the formation of professional competence; modeling method for developing a structural-functional model of the process of formation of professional competence of tourism specialists by means of information and communication technologies. Results. In the context of the research, the essense of the process of formation of the professional competence of the individual is defined and clarified. The concept of “professional competence of tourism specialists” is clarified as an integrative quality, which comprises the level of masterying professional knowledge, abilities, skills and is considered as a process of the subject’s conscious management of his activities and behaviour in accordance with universal value orientations. It is emphasized that the development of information and communication technologies contributes to the modernization of the modern system of tourism education. It goes about distance education as a system of knowledge transfer with the help of various means and technologies and the formation of the students’ skills to use the necessary information in practical professional activities. The author’s definition of the concept of “professional competence of tourism specialists” is presented, which consists in that in the conditions of a computer-oriented information and communication environment. Structural components of the process of formation of professional competence, its content, components are defined. The author has developed a structural and functional model of the process of formation of professional competence of tourism specialists. The structural components of the model and their content are defined.
Air Pollution in Dhaka City During Wintertime: Local vs. Transboundary Transport
Authors: Hossain M L , Rahman A K M Lutfor , Ahmmad N , Sheikh M A A , Arzina T T , Shiraj T B , Haque M M
Published: July 2023

Air pollution is considered as the largest environmental health threat in the world. Last few years, it has also increased dramatically in different cities of Bangladesh. The air pollution of Dhaka city as well as other urban areas is very crucial for a sustainable environment. This research is mainly concentrated on studying a variety of air pollutants both qualitatively and quantitively during wintertime and checking the transboundary air pollution of Dhaka City. In the study area, air pollution was found to be at very dangerous levels. Even, air pollution has been found to be significantly higher in concentration during nighttime in Dhaka City. According to public perception and health physicians, air pollution causes many health problems such as eye irritation, headaches, COPD problem, skin cancer, hypertension, cardiovascular diseases, nausea, and asthma. Regular air quality monitoring can be effective for proper control measures of pollutants emissions that may protect the inhabitants from various illnesses. It can provide a guideline for the sustainable development of environment of city dwellers.

J. of Sci. and Tech. Res. 4(1): 81-90, 2022
Development and Testing of Waste poly(Vinyl Chloride) Based Solvent Cement for Bonding of poly(Vinyl Chloride) Pipes and Fitting
Authors: Sultana S , Sarker M K U , Eti S A
Published: July 2023

Recyclates of waste poly(vinyl chloride) (wPVC) fill materials were used to produce solvent cement. Recyclates of wPVC were made by mechanical recycling of wPVC sheets from power plant cooling tower fill materials. Recyclates of wPVC were analyzed and used to develop solvent cement for bonding of PVC pipes and other molded objects. The formulation of wPVC based solvent cement was optimized. Virgin PVC based solvent cement was also made by applying the same optimized conditions to compare it with wPVC based solvent cement. The newly developed solvent cements were analyzed and applied to PVC pipes to find out their bonding strength compared with the bonding strength of commercial solvent cement. There were no significant differences in the results of these three different solvent cements. So recycling of wPVC into solvent cement is suitable for PVC pipes bonding applications and it has a great potential to achieve benefits for the economic and environmental conditions.

J. of Sci. and Tech. Res. 4(1): 165-172, 2022
Screening of Antimicrobial and Antioxidant Properties of Ethylenediamine Mono-dithiocarbamate to Overcome the Resistance of Microbes Against Existing Drugs
Authors: Sarker A , Ali M Irfan , Arzina T T , Hossain M Lokman , Haque M Aminul , Lutfor Rahman A K M
Published: July 2023

Excellency of the medical treatment depends on the potentiality of drugs. The increase of the resistance of microbes against drugs is influencing this aspect. Dithiocarbamate has an application in medicine and biology. Therefore, we have synthesized ethylenediamine mono-dithiocarbamate ligand and explored its antimicrobial and antioxidant property. The ligand exhibited moderate antibacterial activity against 13 (thirteen) selected bacteria in disk diffusion method. It showed notable antifungal activity compared to the standard. Therefore, this ligand may be considered as a potential antifungal agent in antifungal drug design. The antioxidant behavior using DPPH assay revealed that this ligand has significant capability in scavenging radicals as compared to standard.

J. of Sci. and Tech. Res. 4(1): 183-190, 2022
Các yếu tố quyết định đến năng suất nhân tố tổng hợp của ngành chế biến thủy sản Việt Nam
Authors: Nguyễn Trọng Mạnh , Đinh Thái Quang , Nguyễn Văn
Published: July 2023

Bài viết nhằm phân tích các yếu tố quyết định đến năng suất nhân tố tổng hợp (TFP) của ngành chế biến thủy sản Việt Nam giai đoạn 2015-2020. Đầu tiên, chúng tôi sử dụng phương pháp kiểm soát hàm của Wooldridge (2009) để ước lượng hàm sản xuất và dự báo TFP. Sau đó, chúng tôi phân tích các yếu tố quyết định đến TFP theo năm khía cạnh: Đặc điểm nội bộ của doanh nghiệp; Hoạt động thương mại quốc tế; Hạn chế tài chính; Cường độ cạnh tranh; và Môi trường sản xuất, kinh doanh. Kết quả cho thấy Tuổi và quy mô doanh nghiệp có quan hệ thuận chiều với cả mức TFP và tăng trưởng TFP. Tỷ lệ lợi nhuận trên vốn chủ sở hữu có mối quan hệ ngược chiều với TFP, nhưng thuận chiều với tăng trưởng TFP. Yếu tố xuất nhập khẩu có mối quan hệ tích cực với năng suất, nhưng dư nợ tín dụng thì ngược lại. Cường độ cạnh tranh tác động tích cực đến mức TFP, nhưng tác động tiêu cực đến tăng trưởng TFP. Cuối cùng, các yếu tố về môi trường sản xuất, kinh doanh có mối quan hệ thuận chiều với năng suất.
BIMBINGAN TEKNIS PENGOLAHAN LIMBAH BIJI KARET MENJADI BAHAN BAKU ALTERNATIF PEMBUATAN KERIPIK TEMPE DI DESA JAYAKARTA BENGKULU TENGAH
Authors: Rina Elvia  , Hermansyah Amir  , Pica Lestari
Published: July 2023

Jayakarta merupakan salah satu desa terletak di daerah kecamatan Talang Empat kabupaten Bengkulu Tengah yang memiliki komoditas utama yaitu biji karet. Selama ini biji karet dianggap sebagai limbah, sedangkan yang tumbuh akan menjadi hama bagi pohon karet dewasa. Dengan demikian, dianggap penting untuk melaksanakan  program pengabdian berupa bimbingan teknis untuk mengolah limbah biji karet menjadi keripik tempe yang bernilai ekonomi terkhususnya bagi ibu-ibu rumah tangga di desa tersebut. Dalam pelaksanaan program pengabdian ini dilakukan dalam beberapa tahapan yaitu : tahap persiapan, tahap sosialisasi, tahap bimbingan teknis, tahap pembuatan, dan tahap pengemasan.. Setelah tahapan pembuatan tempe selesai, produk tersebut dijadikan dalam bentuk kemasan berupa keripik. Hal ini dilakukan untuk menjaga produk agar tahan lebih lama dalam proses pemasaran dan penjualan.  Kegiatan ini diharapkan mampu memberikan  keuntungan untuk petani karet dalam membersihkan hama biji karet di area perkebunan serta dapat menjadi peluang peningkatan ekonomi keluarga khususnya bagi ibu rumah tangga di desa Jayakarta.

Kata Kunci: Biji Karet, Tempe, Keripik.
An in silico investigation of allosteric inhibition potential of Dihydroergotamine against Sars-CoV-2 Main Protease (MPro)
Authors: YAŞAR Mehmet Murat , YAŞAR Ekrem , YORULMAZ Nuri , TENEKECİ Emin , SARPÜN İsmail Hakkı , EROĞLU Erol
Published: July 2023

Possible allosteric inhibitors of MPro were investigated using in silico methods. To this end, FDA-approved drugs in the DrugBank database were subjected to virtual screening, and drugs that strongly bind distant from the catalytic site of MPro were identified using molecular docking. Among the identified drugs, Dihydroergotamine (DHE) was chosen for further investigation due to its highest binding score against MPro in the molecular docking experiment. The allosteric inhibition potential of DHE toward MPro was demonstrated by applying some computational tools on the trajectory files which were obtained from the Molecular Dynamics Simulations. Results support that the hydrogen bonding interactions of DHE with GLU278 and THR280, located between Protomer A and Protomer B, affect the structure of the side chain of CYS145 at the catalytic site of MPro. Considering the role of CYS145 in the catalytic cycle, this structural change is likely to be a mechanism for inhibiting MPro.
Simple model for the calculation of concentration and temperature dependent refractive index of different solutions
Authors: FAROOQUE Umar , SİNGH Sandhir Kumar , RASHİD Tarique , ALAM Md. Iftekhar
Published: July 2023

Simple analytical models for the calculation of concentration (c) and temperature (T) dependent refractive index i.e., n(c,T) values of the six solutions namely, three electrolyte (KCl, NaCl, and CaCl2), a polar (glucose), a non-polar (ethyl acetate), and a protein (bovine serum albumin) solutions have been proposed. The values of refractive index obtained using our proposed models have been compared with the corresponding values of the refractive index obtained using other reported models and the experimental values. A fairly good agreement between them has been obtained.
Microbiota e dieta: importância da modulação intestinal com foco na obesidade
Authors: Borba Ana Paula Aparecida de , Ramos Lara Rosa Campos de Araújo , Maynard Dayanne da Costa
Published: July 2023

Os estudos sobre microbiota intestinal estão sendo cada vez mais discutidos para mostrar a relevância e o impacto que pode gerar na vida dos indivíduos. A modulação da microbiota intestinal pode promover diversos resultados no organismo, sendo alguns deles: melhor absorção de nutrientes, síntese de vitaminas, modulação do sistema endócrino e em todo o metabolismo. O objetivo do trabalho foi analisar os pontos que comprovem que a ingestão de gordura e açúcar contribuem para uma microbiota em desequilíbrio e que as características de cada uma contribuem para a qualidade de vida em geral. O estudo consiste em uma pesquisa de revisão narrativa acerca da influência da dieta na microbiota e sua relação com a obesidade. Foi realizada uma pesquisa nos bancos de dados PubMed, SciELO, Google Acadêmico, bem como livros e periódicos com os descritores microbiota; modulação; intestino; emagrecimento; ciclo circadiano; sono; atividade física; inflamação; hormônios; estresse; probióticos; mitocôndrias; dieta; glúten, foodmap, entre os anos de 2006 e 2023 nas línguas português e inglês. Os resultados encontrados levaram a conclusão de que o emagrecimento é uma das condições onde é possível notar a importância de manter a microbiota intestinal saudável, visto que, ao se alimentar bem, praticar atividade física, consumir a quantidade ideal de água e ingerir alimentos ricos em prebióticos, o intestino funciona corretamente e aumenta a chance de absorver melhor os alimentos, além disso, a microbiota intestinal de um indivíduo obeso é diferente da microbiota intestinal de indivíduo não obeso.
Frequência de infecção pelo SARS-CoV-2 em diferentes grupos de trabalhadores e os efeitos da atividade física
Authors: Costa Victor Negri Andrade , Azevedo Taiza dos Santos , Dias Jonas Hoffmann Vogelzang , Pinto Thiago Lorentz , Endlich Patrick Wander
Published: July 2023

Introdução: Durante a pandemia causada pelo SARS-CoV-2, o distanciamento foi uma grande ferramenta, mas impraticável para muitos. Nesse sentido, destacamos algumas categorias profissionais, como os cobradores de ônibus que estavam expostos a ambientes com pouca circulação de ar e os coletores de lixo que são expostos a superfícies contaminadas, mas apresentam um possível fator protetor pela aumentada capacidade aeróbica. Objetivos: Assim, o estudo visa analisar a frequência de infecção pelo SARS-CoV-2 e nível de atividade física dos trabalhadores, além de comparar a taxa do pico de fluxo expiratório (TPFE) pós COVID-19. Métodos: Para isso, foi realizado um estudo observacional retrospectivo analítico transversal com 52 trabalhadores, nos grupos: profissionais do setor de transporte coletivo urbano (N=18); trabalhadores de limpeza urbana (N=21); e servidores públicos que trabalharam remotamente (N=13). O nível de atividade física foi mensurado via versão longa do Questionário Internacional de Atividade Física e TPFE usando um Peak Flow. Resultados: Observou-se uma taxa de infecção pelo SARS-CoV-2 de 19% para profissionais de limpeza urbana, 44% para cobradores de ônibus e 61,5% para servidores públicos, demonstrando diferença significativa na probabilidade de ser infectado pelo SARS-CoV-2 e desenvolver COVID-19 nesses grupos. Dois trabalhadores alegaram ter doenças pulmonares obstrutivas, embora três trabalhadores apresentaram TPFE abaixo de 80%, o que possivelmente indica presença dessas doenças. Conclusões: Assim, há diferença significativa na probabilidade de ser infectado pelo SARS-CoV-2 e desenvolver COVID-19 em cada grupo, que não pôde ser explicada pela diferença no nível de atividade física entre os grupos.
Processos mnemônicos e os depoimentos no processo penal - uma revisão
Authors: Lopes Alexia Soares Montingelli , Silva Rodrigo Faucz Pereira e
Published: July 2023

O objetivo do presente artigo é elucidar as possíveis influências da falibilidade da memória no testemunho, por meio da aplicação da metodologia científica da revisão de literatura. A memória é um aspecto essencial da cognição humana, que possibilita ao indivíduo codificar, armazenar e recuperar informações sobre eventos passados, formada por um complexo processo, múltiplos estágios e regiões cerebrais. Detendo um papel crucial na prova testemunhal, a qual se refere a um fato relatado por uma pessoa, que efetivamente o presenciou ou tem conhecimento de algum fato relevante, mas isso não quer dizer que sempre será preciso, já que pode ser influenciada por uma variedade de fatores internos e externos. As influências podem ser as mais diversas, desde atenção, emoções, motivações, idade, doenças, lesões, inclusive a mídia, conversas com terceiros e a condução da oitiva. O operador do direito, precisa levar esses aspectos em consideração, frente a execução de seu trabalho, buscando dirimir as influências e mitigar a força dessa modalidade probatória, além de dar prioridade às provas materiais em vez de depender exclusivamente da prova testemunhal, possibilitando uma maior assertividade.
Efecto de la intensidad de la luz de curado dental sobre las resinas dentales en cuanto a su estructura y forma: revisión de la literatura
Authors: Morocho Llivizaca Karina Viviana , Ordóñez Tocto Lourdes Margoth , Palacios Astudillo Iván Andrés
Published: July 2023

Los materiales dentales a base de resina son ampliamente utilizados en odontología restauradora debido a su estética, versatilidad y durabilidad, por lo que el fotocurado es un proceso crucial en la polimerización de estos materiales. Objetivo: Identificar el efecto que produce la intensidad de la luz de la lámpara de fotocurado en los materiales dentales a base de resina en cuanto a su estructura y forma. Metodología: El presente estudio, yace en una revisión bibliográfica, misma que toma como eje de estudios a artículos científicos relacionados con la odontología restaurativa, y los efectos de la intensidad lumínica de las lámparas de fotocurado sobre las resinas dentales en cuanto a su estructura y forma, lo que brindará una actualización literaria. Conclusión: Un adecuado fotocurado de las resinas da como resultado mejores propiedades mecánicas y un fotocurado incorrecto puede alterar negativamente las propiedades del material, causando sensibilidad, microfiltración, inestabilidad del color, fatiga, desgaste, aumento de la absorción de agua y solubilidad.
Penggunaan gaya bahasa sarkasme pada film Lara Ati Karya Bayu Skak
Authors: Asmi Asmi Anjiani , Nugrahani Ari
Published: July 2023

Gaya bahasa sarkasme adalah fokus dari penelitian ini dan permasalahan yang dikaji dalam penelitian ini adalah (1) bagaimanakah bentuk gaya bahasa sarkasme pada film Lara Ati Karya Bayu Skak? (2) bagaimanakah makna gaya bahasa sarkasme yang terdapat pada film Lara Ati Karya Bayu Skak?. Berdasarkan permasalahan tersebut, tujuan penelitian ini adalah (1) Mendeskripsikan bentuk gaya bahasa sarkasme yang terdapat pada film Lara Ati Karya Bayu Skak (2) Mendeskripsikan makna gaya bahasa sarkasme yang terdapat pada film Lara Ati Karya Bayu Skak. Metode penelitian ini adalah metode deskriptif dengan data analisis kualitatif. Teknik pengumpulan data dalam penelitian ini menggunakan teknik simak dan catat. Hasil penelitian menunjukkan gaya bahasa sarkasme dalam film Lara Ati Karya Bayu Skak terdapat 23 data bentuk dan makna gaya bahasa sarkasme yang terdiri dari ejekan dan sindiran. Penelitian ini diharapkan dapat menjadi referensi bagi pembaca, khususnya yang ingin melakukan penelitian lebih mendalam tentang gaya bahasa sarkasme.
Penetapan Kadar Saponin dalam Gambas (Luffa acutangula L.) Hasil Pengeringan Matahari dan Pengeringan Oven Menggunakan Metode Gravimetri
Authors:   Sekolah Tinggi Imu Kesehatan Nasional, Fitrianingsih Natasya Hanindita , Lindawati Novena Yety ,   Sekolah Tinggi Imu Kesehatan Nasional
Published: July 2023

Gambas fruit or oyong or often called ceme (Luffa acutangula L) or ridged gourd is a plant that belongs to the Cucurbitaceae family. Gambas fruit contains several important nutrients and also contains several chemical compounds, one of which is saponin which can be useful as an experctorant, antitussive, antidiabetic, anticholesterol, anticancer, antibacterial and antifungal. This research was conducted with the aim of knowing the differences in saponin levels and differences in yield in sun-dried and oven-dried squash fruits. Differences in temperature and drying method may allow for differences in the yield and saponin levels in the squash. Determination of saponin levels was carried out using the gravimetric method which was the advantage of not requiring a comparator (standard saponins). The result showed that the sun drying yield was 8,24% with ±SD 0,00021 and the oven drying yield was 7,21% with ±SD 0,02821 while the saponin content in sun drying was 0,39% with a coefficient of variation of 0,001% and oven drying saponin content of 11,96% with a coefficient of variation of 0,002%.
Analisis Rentabilitas Bank Syariah Saat Pandemic Covid-19 Di Indonesia
Authors: Sakdiyah Umi , Fahlevi Rizal
Published: July 2023

The purpose of this study was to find out how much influence ROA, NPF and BOPO had on NOM of Islamic banks before and during the covid-19 pandemic. This study applies a quantitative method with secondary data types obtained from financial statements of Islamic banks in the form of time series. The results of the study show that the effect of ROA before the pandemic is smaller than during the pandemic, meaning that the ability of Islamic bank management to earn profits during the pandemic has decreased overall. NPF has a very big influence during a pandemic, meaning that there is an increase in problem financing due to the impact of Covid-19 which has affected the economic sector. BOPO has no influence during a pandemic, meaning that management is able to reduce operational costs, this occurs because during a pandemic operational management switches to using an internet technology system which can reduce operational costs rather than a manual system. Simultaneously, ROA, NPF and BOPO both have an influence on the NOM of Islamic banks, the influence during a pandemic is greater than before the pandemic, this occurs because the NPF variable relating to problem financing during a pandemic is very large.
PSİKOLOJİK SAĞLAMLIĞIN PSİKİYATRİK SEMPTOMLAR SAĞLIK KAYGISI VE SİBERKONDRİA İLİŞKİSİNDE ARACILIK ROLÜNÜN İNCELENMESİ
Authors: YÜCEL Duygu , ASLAN Hilal , ARICAK Osman
Published: July 2023

Bu araştırmada, psikolojik sağlamlığın psikiyatrik semptomlar, sağlık kaygısı ve siberkondria ilişkisinde aracılık rolünün incelenmesi amaçlanmıştır. Bu amaç doğrultusunda 454 üniversite öğrencisinin katılımı ile araştırma yürütülmüştür. Katılımcılara Siberkondria Şiddeti Ölçeği, Kısa Psikolojik Sağlamlık Ölçeği, Kısa Semptom Envanteri, Sağlık Anksiyetesi Envanteri Kısa Formu uygulanmıştır. Elde edilen sonuçlara göre; sağlık kaygısı ile psikiyatrik semptomlar ve siberkondria arasında anlamlı ve pozitif bir ilişki bulunmaktadır. Aynı zamanda, psikiyatrik semptomlar ile siberkondria arasında da anlamlı ve pozitif bir ilişki gözlemlenmiştir. Psikolojik sağlamlık ile sağlık kaygısı, psikiyatrik semptomlar ve siberkondria arasında ise anlamlı ve negatif bir ilişki vardır. Psikolojik sağlamlığın siberkondria ile ilişkisi anlamlı bulunmasına rağmen, psikolojik sağlamlığın siberkondria ile psikiyatrik semptomlar ve sağlık kaygısı arasındaki ilişkide aracılık rolü olmadığı gözlemlenmiştir. Bulgular literatür ışığında tartışılmış, araştırma ile ilgili sınırlılıklara ve gelecek araştırmacılar için önerilere yer verilmiştir.
DISCURSO EM CARTA ABERTA:
Authors: Fernandes Pimenta de Almeida Lima Fernanda , Pereira dos Reis Warlles
Published: July 2023

O presente artigo busca, por meio da análise de duas cartas abertas publicadas na mídia digital e impressa, discutir um tema que tem motivado polêmicas, sobretudo pelas cinesias que não se consentem sobre a prática do “aborto”. Para este trabalho, que se configura em um pesquisa empírica de cunho interpretativo e documental, analisamos duas cartas abertas com posicionamentos opostos sobre a legalização do aborto. Embasamo-nos no postulado da Análise do Discurso francesa e em teóricos que fundamentam seu quadro conceitual. Por entendermos que a sala de aula é o locus adequado para se discutirem práticas subjetivas e sociais, neste artigo analisamos como se sustentam a defesa ou a negação sobre o aborto por diferentes discursos historicamente constituídos. Afora, trata-se de uma reflexão sobre enunciados que se embatem e remetem a um tema que, não raro, é interditado à sala de aula.
EDUCAÇÃO ESTÉTICA NA FORMAÇÃO INICIAL DE PEDAGOGIA POR MEIO DE VIVÊNCIAS LITERÁRIAS:
Authors: Pedroso Bruns Juliana , BUZZI RAUSCH RITA
Published: July 2023

A partir do estado da questão, objetivamos identificar o que dizem as teses publicadas no Brasil sobre a educação estética por meio de vivências literárias na formação inicial de professores no curso de Pedagogia. Foram localizadas 20 teses na CAPES e BDTD – IBICT, dessas, duas foram selecionadas. Como resultados, a tese de Moraes (2015) evidenciou que: i) não há uma só proposta de educação estética na universidade; ii) a apropriação de saberes artísticos é fundamental para os trabalhos educativos. Já a tese de Queiros (2019) demonstrou: i) carência de políticas que se efetivem numa prática coerente com a realidade dos leitores; ii) deficiência de leitura literária na graduação; iii) falta de entusiasmo por parte dos graduandos; e, iiii) ausência de protagonismo frente à própria formação. Esperamos que a pesquisa possa contribuir para ampliar e possibilitar referenciais para refletir sobre a temática apresentada.
Engineered biomimetic micro/nano-materials for tissue regeneration
Authors: Han Feng , Meng Qingchen , Xie En , Li Kexin , Hu Jie , Chen Qianglong , Li Jiaying , Han Fengxuan
Published: July 2023

The incidence of tissue and organ damage caused by various diseases is increasing worldwide. Tissue engineering is a promising strategy of tackling this problem because of its potential to regenerate or replace damaged tissues and organs. The biochemical and biophysical cues of biomaterials can stimulate and induce biological activities such as cell adhesion, proliferation and differentiation, and ultimately achieve tissue repair and regeneration. Micro/nano materials are a special type of biomaterial that can mimic the microstructure of tissues on a microscopic scale due to its precise construction, further providing scaffolds with specific three-dimensional structures to guide the activities of cells. The study and application of biomimetic micro/nano-materials have greatly promoted the development of tissue engineering. This review aims to provide an overview of the different types of micro/nanomaterials, their preparation methods and their application in tissue regeneration.
LIPUS-S/B@NPs regulates the release of SDF-1 and BMP-2 to promote stem cell recruitment-osteogenesis for periodontal bone regeneration
Authors: Yan Shujin , Wang Dong , Zhang Liang , Gan Tian , Yao Huan , Zhu Hui , He Yiman , Yang Ke
Published: July 2023

Purpose: Poly (lactic-co-glycolic acid)-based nanoparticles (PLGA NPs) have been widely used as the carrier for sustainable drug delivery. However, the drug release from the NPs was usually incomplete and uncontrollable. Herein, a low intensity pulsed ultrasound (LIPUS) assisted SDF-1/BMP-2@nanoparticles (S/B@NPs) system was fabricated to facilitate stem cell recruitment-osteogenesis for periodontal bone regeneration.

Methods: In this work, S/B@NPs were prepared with double-emulsion synthesis method. Then the S/B release profile from NPs was evaluated with or without low intensity pulsed ultrasound treatment. Afterwards, the stem cell recruiting and osteoinductive capacities of LIPUS-S/B@NPs were detected with human periodontal ligament cells (hPDLCs) in vitro and in a rat periodontal bone defect model.

Results: The results indicated that S/B@NPs were successfully prepared and LIPUS could effectively regulate the release of S/B and increase their final releasing amount. Moreover, LIPUS-S/B@NPs system significantly promoted hPDLCs migrating and osteogenesis in vitro and recruiting rBMSCs to the rat periodontal defect and facilitated bone regeneration in vivo.

Conclusion: Our LIPUS assisted S/B@NPs system can effectively facilitate stem cell recruitment and periodontal bone regeneration. Considering its reliable safety and therapeutic effect on bone fracture, LIPUS, as an adjuvant therapy, holds great potential in the regulation of drug delivery systems for bone healing.
The combination of NDUFS1 with CD4+ T cell infiltration predicts favorable prognosis in kidney renal clear cell carcinoma
Authors: Wu Dong , He Lin , Xu Zhe , Tian Ruo-Fei , Fan Xin-Yu , Fan Jing , Ai Jie , Bian Hui-Jie , Qin Wei-Jun , Qin Jun , Li Ling
Published: July 2023

Background: Kidney renal clear cell carcinoma (KIRC) is an immunogenic tumor, and immune infiltrates are relevant to patients’ therapeutic response and prognosis. NDUFS1, the core subunit of mitochondrial complex I, has been reported to be associated with KIRC patients’ prognosis. However, the upstream regulator for NDUFS1 and their correlations with immune infiltration remain unclear.

Methods: The expression of NDUFS genes in KIRC and their influences on patients’ survival were investigated by UALCAN, ENCORI, Oncomine, TIMER as well as Kaplan-Meier Plotter. miRNAs regulating NDUFS1 were predicted and analyzed by TargetScan and ENCORI. The correlations between NDUFS1 expression and immune cell infiltration or gene marker sets of immune infiltrates were analyzed via TIMER. The overall survival in high/low NDUFS1 or hsa-miR-320b expressed KIRC patients with or without immune infiltrates were analyzed via Kaplan-Meier Plotter. The combined NDUFS1 expression and/or CD4+ T cell infiltration on KIRC patients’ overall survival were validated by multiplexed immunofluorescence (mIF) staining in tissue microarray (TMA). Furthermore, the influences of NDUFS1 expression on the chemotaxis of CD4+ T cells to KIRC cells were performed by transwell migration assays.

Results: We found that the low expression of NDUFS1 mRNA and protein in KIRC was correlated with unfavorable patients’ survival and poor infiltration of CD4+ T cells. In patients with decreased CD4+ T cell infiltration whose pathological grade less than III, TMA mIF staining showed that low expression of NDUFS1 had significantly poor OS than that with high expression of NDUFS1 did. Furthermore, hsa-miR-320b, a possible negative regulator of NDUFS1, was highly expressed in KIRC. And, low NDUFS1 or high hsa-miR-320b consistently correlated to unfavorable outcomes in KIRC patients with decreased CD4+ T cell infiltration. In vitro, NDUFS1 overexpression significantly increased the chemotaxis of CD4+ T cell to KIRC cells.

Conclusion: Together, NDUFS1, upregulated by decreased hsa-miR-320b expression in KIRC patients, might act as a biomarker for CD4+ T cell infiltration. And, the combination of NDUFS1 with CD4+ T cell infiltration predicts favorable prognosis in KIRC.
Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
Authors: Mattioni Marchetti Vittoria , Hrabak Jaroslav , Bitar Ibrahim
Published: July 2023

Antimicrobial resistance is well-known to be a global health and development threat. Due to the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as fosfomycin (FOS), have been necessary. FOS is a phosphonic acid derivate that regained interest in clinical practice for the treatment of complicated infection by multi-drug resistant (MDR) bacteria. Globally, FOS resistant Gram-negative pathogens are raising, affecting the public health, and compromising the use of the antibiotic. In particular, the increased prevalence of FOS resistance (FOSR) profiles among Enterobacterales family is concerning. Decrease in FOS effectiveness can be caused by i) alteration of FOS influx inside bacterial cell or ii) acquiring antimicrobial resistance genes. In this review, we investigate the main components implicated in FOS flow and report specific mutations that affect FOS influx inside bacterial cell and, thus, its effectiveness. FosA enzymes were identified in 1980 from Serratia marcescens but only in recent years the scientific community has started studying their spread. We summarize the global epidemiology of FosA/C2/L1-2 enzymes among Enterobacterales family. To date, 11 different variants of FosA have been reported globally. Among acquired mechanisms, FosA3 is the most spread variant in Enterobacterales, followed by FosA7 and FosA5. Based on recently published studies, we clarify and represent the molecular and genetic composition of fosA/C2 genes enviroment, analyzing the mechanisms by which such genes are slowly transmitting in emerging and high-risk clones, such as E. coli ST69 and ST131, and K. pneumoniae ST11. FOS is indicated as first line option against uncomplicated urinary tract infections and shows remarkable qualities in combination with other antibiotics. A rapid and accurate identification of FOSR type in Enterobacterales is difficult to achieve due to the lack of commercial phenotypic susceptibility tests and of rapid systems for MIC detection.
A rat model of metabolic syndrome-related heart failure with preserved ejection fraction phenotype: pathological alterations and possible molecular mechanisms
Authors: Shi Yujiao , Liu Chunqiu , Yang Chenguang , Qiao Wenbo , Liu Yongcheng , Liu Siyu , Dong GuoJu
Published: July 2023

Background

Heart failure with preserved ejection fraction (HFpEF) represents a syndrome involving multiple pathophysiologic disorders and clinical phenotypes. This complexity makes it challenging to develop a comprehensive preclinical model, which presents an obstacle to elucidating disease mechanisms and developing new drugs. Metabolic syndrome (MetS) is a major phenotype of HFpEF. Thus, we produced a rat model of the MetS-related HFpEF phenotype and explored the molecular mechanisms underpinning the observed pathological changes.

Methods

A rat model of the MetS-related HFpEF phenotype was created by feeding spontaneously hypertensive rats a high-fat-salt-sugar diet and administering streptozotocin solution intraperitoneally. Subsequently, pathological changes in the rat heart and their possible molecular mechanisms were explored.

Results

The HFpEF rats demonstrated primary features of MetS, such as hypertension, hyperglycemia, hyperlipidemia, insulin resistance, and cardiac anomalies, such as left ventricular (LV) remodeling and diastolic impairment, and left atrial dilation. Additionally, inflammation, myocardial hypertrophy, and fibrosis were observed in LV myocardial tissue, which may be associated with diverse cellular and molecular signaling cascades. First, the inflammatory response might be related to the overexpression of inflammatory regulators (growth differentiation factor 15 (GDF-15), intercellular adhesion molecule-1 (ICAM-1), and vascular endothelial cell adhesion molecule-1 (VCAM-1)). Secondly, phosphorylated glycogen synthase kinase 3β (GSK-3β) may stimulate cardiac hypertrophy, which was regulated by activated -RAC-alpha serine/threonine-protein kinase (AKT). Finally, the transforming growth factor-β1 (TGF-β1)/Smads pathway might regulate collagen production and fibroblast activation, promoting myocardial fibrosis.

Conclusion

The HFpEF rat replicates the pathology and clinical presentation of human HFpEF with MetS and may be a reliable preclinical model that helps elucidate HFpEF pathogenesis and develop effective treatment strategies.
Wikipedia page views for health research: a review
Authors: Alibudbud Rowalt
Published: July 2023

Wikipedia is an open-source online encyclopedia and one of the most-read sources of online health information. Likewise, Wikipedia page views have also been analyzed to inform public health services and policies. The present review analyzed 29 studies utilizing Wikipedia page views for health research. Most reviewed studies were published in recent years and emanated from high-income countries. Together with Wikipedia page views, most studies also used data from other internet sources, such as Google, Twitter, YouTube, and Reddit. The reviewed studies also explored various non-communicable diseases, infectious diseases, and health interventions to describe changes in the utilization of online health information from Wikipedia, to examine the effect of public events on public interest and information usage about health-related Wikipedia pages, to estimate and predict the incidence and prevalence of diseases, to predict data from other internet data sources, to evaluate the effectiveness of health education activities, and to explore the evolution of a health topic. Given some of the limitations in replicating some of the reviewed studies, future research can specify the specific Wikipedia page or pages analyzed, the language of the Wikipedia pages examined, dates of data collection, dates explored, type of data, and whether page views were limited to Internet users and whether web crawlers and redirects to the Wikipedia page were included. Future research can also explore public interest in other commonly read health topics available in Wikipedia, develop Wikipedia-based models that can be used to predict disease incidence and improve Wikipedia-based health education activities.
Study on the environmental effect on human being detection using the UWB bio-radar
Authors: Ma Teng , Qi Fugui , Yu Xiao , Jiao Teng , Lv Hao , Wang Jianqi
Published: July 2023

Objective: Non-contact penetrating detection and sensing of human beings (vital signs) through nonmetallic obstacles (ruins, wall, and smog) using the ultra-wideband (UWB) bio-radar plays a significant role in various post-disaster rescue operations in national public security events, like earthquake, building collapse, and factory explosion. In practical application scenarios, the narrowband radio frequency interference (RFI) and surrounding movement interference (SMI) are the two most common and major types of environmental interference (EI), which would cause serious effects on the penetrating detection performance of the UWB bio-radar.

Methods: Therefore, through establishing a quantitative and controllable experiment system and combining a proposed quantitative evaluation method, this paper quantitatively investigates and evaluates the influencing characteristics and laws of these two interferences on human vital sign detection using the UWB bio-radar. In the quantitative experiments, two key environmental spatial parameters (interference distance and angle) of interference sources and two kinds of system parameters (main lobe width and time window) of the UWB bio-radar are considered.

Results: Numerous experiments at different interference positions and corresponding statistical results demonstrated that both the RFI and SMI have a high negative correlation with the interference distance. Meanwhile, the SMI, which is highly related to the interference angle, could be screened or isolated by the detecting time window and main lobe boundary of UWB bio-radar, but the RFI could not be detected.

Discussion: This study shows potential in providing transcendental knowledge and guidance for special EI suppression study, and even for the future design, manufacture, and rational use of the UWB bio-radar, facilitating improvement in the practical performance and effectiveness of the UWB bio-radar search and rescue system.
Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial
Authors: Arhab Amar , Junod Nicolas , Rossel Jean-Benoit , Giet Olivier , Sittarame Frederic , Beer Sandra , Sofra Daniela , Durrer Dominique , Delgado Humberto , Castellsague Montserrat , Laimer Markus , Puder Jardena J.
Published: July 2023

Introduction

The aim of this study was to evaluate the effectiveness of a real-life clinical physical activity program (DIAfit) on improving physical fitness, body composition, and cardiometabolic health in an unselected population with type 2 diabetes mellitus, and to compare the effects of two variants a different exercise frequencies on the same outcomes.

Research design and methods

This was a cluster randomized-controlled assessor-blind trial conducted in 11 clinical centres in Switzerland. All participants in the clinical program with type 2 diabetes were eligible and were randomized to either standard (3 sessions/week for 12 weeks) or alternative (1 session/week for the first four weeks, then 2 sessions/week for the rest of 16 weeks) physical activity program each consisting of 36 sessions of combined aerobic and resistance exercise. Allocation was concealed by a central office unrelated to the study. The primary outcome was aerobic fitness. Secondary outcome measures included: body composition, BMI, HbA1c, muscle strength, walking speed, balance, flexibility, blood pressure, lipid profile.

Results

All 185 patients with type 2 diabetes (mean age 59.7 +-10.2 years, 48% women) agreed to participate and were randomized in two groups: a standard group (n=88) and an alternative group (n=97)). There was an 11% increase in aerobic fitness after the program (12.5 Watts; 95% CI 6.76 to 18.25; p<0.001). Significant improvements in physical fitness, body composition, and cardiometabolic parameters were observed at the end of the DIAfit program (improvements between 2-29%) except for lean body mass, triglycerides and cholesterol. No differences were observed between both programs, except for a larger weight reduction of -0.97kg (95% CI -0.04 to -1.91; p=0.04) in the standard program.

Conclusions

Both frequency variants of the nation-wide DIAfit program had beneficial effects on physical fitness, HbA1c, body composition, and blood pressure in type 2 diabetes patients and differences were negligible.

Clinical trial registration

clinicaltrials.gov, identifier NCT01289587.
The gut-retina axis: a new perspective in the prevention and treatment of diabetic retinopathy
Authors: Zhang Haiyan , Mo Ya
Published: July 2023

Diabetic retinopathy (DR) is a microvascular lesion that occurs as a complication of diabetes mellitus. Many studies reveal that retinal neurodegeneration occurs early in its pathogenesis, and abnormal retinal function can occur in patients without any signs of microvascular abnormalities. The gut microbiota is a large, diverse colony of microorganisms that colonize the human intestine. Studies indicated that the gut microbiota is involved in the pathophysiological processes of DR and plays an important role in its development. On the one hand, numerous studies demonstrated the involvement of gut microbiota in retinal neurodegeneration. On the other hand, alterations in gut bacteria in RD patients can cause or exacerbate DR. The present review aims to underline the critical relationship between gut microbiota and DR. After a brief overview of the composition, function, and essential role of the gut microbiota in ocular health, and the review explores the concept of the gut-retina axis and the conditions of the gut-retina axis crosstalk. Because gut dysbiosis has been associated with DR, the review intends to determine changes in the gut microbiome in DR, the hypothesized mechanisms linking to the gut-retina axis, and its predictive potential.
Taxonomic distribution of opsin families inferred from UniProt Reference Proteomes and a suite of opsin-specific hidden Markov models
Authors: Clarke Neil D. , Taylor John S.
Published: July 2023

Introduction

Opsins are a large and sequence-diverse family of light-responsive G-protein coupled receptors involved in vision, circadian rhythm, and other processes. Numerous subfamilies have been defined based on sequence similarity, cell-type localization, signal transduction mechanism, or biological function, but there is no consensus classification system.

Methods

We used multiple hidden Markov models (HMMs) to identify opsins in the UniProt Reference Proteomes database. Opsin-specific HMMs were also used in an annotation procedure that represents sequences as a vector of HMM scores and assess the similarity of these vectors to those of annotated sequences. UniProt Reference Proteomes are built from genome sequences, allowing us to make meaningful comparisons of the number of opsins in each of the 260 species available at the time of the survey in absolute terms and relative to a larger superfamily of which opsins are a member.

Results

More than 2,000 opsins were retrieved from 262 species (all metazoans).

Discussion

Merging opsin counts into higher order taxa paints a broad view of the taxonomic distribution of opsins, and of opsin subfamilies, annotated according to three different schemes.