bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of the receptor phenotype of tumor-associated immune cells of the epithelial-mesenchymal microenvironment of ovarian cancer
Authors: Zhurman Varvara N.
Published: May 2023

Among all histological types, serous carcinomas account for up to 85%. Due to pronounced heterogeneity (at the molecular and genetic level) and chemoresistance, difficulties arise in finding active targets for tumor elimination.
Aim. To establish a link between the population composition of tumor-associated immune cells of the microenvironment and the stage of serous ovarian cancer.
Materials and methods. The analysis of the pathologic and anatomical material in 74 patients with serous ovarian cancer was carried out. Monoclonal antibodies were used to determine antigens in the samples: CD3, CD4, CD8, CD11b, CD14 and CD16.
Results. The obtained results of the immunohistochemical study showed that in the composition of the immune cells of the microenvironment, the largest number of cells, at all stages (IIV) of the oncological process, are represented by macrophages (CD11b+, CD14+), CD3+ lymphocytes are in second place in terms of the number of cells, followed by CD8+ and CD4+ and the smallest number of CD16+ cells.
Conclusion. As a result of the immunohistochemical study, a multidirectional trend was found between the population composition of tumor-associated immune cells of the microenvironment and the stage of serous ovarian cancer. With an increase in the stage of the disease, the number of macrophages (CD11b+, CD14+) and lymphocytes (CD3+, CD16+) decreased regardless of the degree of differentiation of the tumor. With an increase in the tumor stage, the number of CD4+ and CD8+ populations decreased, but in this case, the degree of differentiation played a significant role, i.e. the higher the tumor stage and the lower the degree of differentiation, the fewer cells were detected.
Immunological detection of bone marrow lesions in skin melanoma and its clinical significance: Observational study
Authors: Krylovetskaya Maria A. , Chulkova Svetlana V. , Markina Irina G. , Chernysheva Olga A. , Komarov Igor G. , Kolbatskaya Olga P. , Kupryshina Natalya A. , Logachev Andrey V. , Mikhaylova Irina N. , Demidov Lev V. , Tupitsyn Nikolai N.
Published: May 2023

Background. Melanoma of the skin is characterized by a rapid progression and early metastasis. It has been shown the disseminated tumor cells, which are often found in the bone marrow, has an important prognostic value. The study of disseminated tumor cells in melanoma might be one of the possible additional sources of information about the nature of the disease and potential application points for drug therapy.
Aim. To study the frequency of detection of disseminated tumor cells in the bone marrow in melanoma, depending on the clinical and morphological characteristics of the tumor.
Materials and methods. The study included 67 patients with a verified diagnosis of melanoma who were examined and treated at the Blokhin National Medical Research Center of Oncology from 2014 to 2019 years. Male patients accounted for 50.7% (n=34), female patients 49.3% (n=33). The average age of patients: 50.11.6 years. Immunological and morphological examination of the bone marrow were perfomed. Morphological examination was performed by two independent morphologists. Disseminated tumor cells were evaluated by flow cytometry among all nucleated cells (Syto41+) based on the expression of the HMB-45 antigen and the absence of expression of the CD45 panleukocyte antigen (FACS Canto II, USA, Kaluza Analysis v2.1). Statistical data processing was performed using the IBM-SPSS Statistics v.21
Results. Morphologically bone marrow damage was not detected in any case. Disseminated tumor cells (CD45-HMB-45+) in the bone marrow of melanoma patients were detected in 62.7% (n=42) of cases by flow cytometry. The frequency of bone marrow damage in the early stages is not lower than in advanced ones (p=0.029). This is clearly seen in the enlarged analysis. The percentage of DTC detection. At stages I and II was 60.0% (6/10) and 84.6% (11/13), respectively, at stages III and IV 44.4% (8/18) and 65.4% (17/26). In addition, the frequency of detection of disseminated tumor cells in the bone marrow was higher in young patients (p=0.02). There was no correlation between the frequency of bone marrow damage depending on BRAF status.
Conclusion. The connection of disseminated tumor cells with the clinical and morphological characteristics of the melanoma has been established. Melanoma is characterized by frequent bone marrow damage, even in the early stages, in young patients.
Clinical factors of the risk of hyperplastic endometry processes on tamoxifen therapy with breast cancer: Retrospective population study
Authors: Golubenko Ekaterina O. , Savelyeva Marina I. , Poddubnaya Irina V. , Korennaya Vera V.
Published: May 2023

Background. One of the main stages of the treatment of breast cancer (BC) is endocrine therapy with tamoxifen or aromatase inhibitors. Five years of adjuvant tamoxifen therapy reduces the risk of disease recurrence by 39%. Tamoxifen was approved by the U.S. Food and Drug Administration in 1977 as a treatment for ER-positive BC. However, sometime after the start of tamoxifen's wide use, reports have been published on its long-term adverse effects. Most common were hot flashes, gynecological symptoms (vaginal dryness, vaginal discharge), depression, forgetfulness, sleep changes, weight gain, and decreased libido. However, more serious adverse events such as venous thromboembolic disease and endometrial hyperplasia or cancer are the most clinically significant. The article presents the results of a retrospective population-based study on assessing hyperplastic processes of the endometrium (HPE) in patients with breast cancer during TAM therapy, conducted in 2017, approved by the Ethics Committee of the Scientific Research of the Russian Medical Academy of Continuing Professional Education. Aim. To identify clinical factors that may increase the risk of HPE during tamoxifen therapy in patients with a history of breast cancer living in the Moscow region. Materials and methods. We retrospectively reviewed 230 case histories of patients with breast cancer. Of these, 120 patients who received TAM therapy had the following HPE risk factors: average age, menopausal status, body mass index, and duration of TAM therapy. Results. It was found that patients with HPE taking TAM were older (p=0.017), more likely to be postmenopausal (p=0.035), overweight (p=0.023), and received TAM for a longer period (p=0.028) than patients without HPE. Conclusion. The data obtained indicate the need for continuous monitoring by gynecologists of patients with breast cancer taking tamoxifen, paying particular attention to women from high-risk groups, namely older postmenopausal women with high body mass index receiving TAM for more than 1.52 years.
Prevention of febrile neutropenia in oncological patients: real-world data
Authors: Sapozhnikov Kirill V. , Sorokina Irina V. , Gusev Aleksandr V. , Sableva Natalia A. , Sokolova Valeriia D. , Tolkacheva Daria G. , Berezina Anna M.
Published: May 2023

Aim. To assess the effect of febrile neutropenia (FN) prophylaxis with granulocyte colony-stimulating factors (G-CSF) in real-world cancer patients.
Materials and methods. We conducted a statistical analysis of anonymized medical records collected in the Webiomed platform. Before analysis, the cards were validated by clinical experts. Electronic records were extracted according to two principles: mentioning D70 in the diagnosis or mentioning a chemotherapy regimen associated with a high risk of FN (20%), requiring the primary prevention of neutropenia. Thus, we obtained two datasets comprising 47.085 (590 patients) and 30.523 (398 patients) records, respectively.
Results. Based on the analysis results, the most common risk factors for FN development were highly hematologically toxic chemotherapy regimens and elderly age about 50% in the adult population. In both datasets, the number of female patients prevailed (63.7% in dataset 1, 91.2% in dataset 2), so the most common was breast cancer. Less common were cervical cancer, digestive cancer, and lung cancer. Despite the indications for primary prevention of FN, for safety and importance of achieving the planned dose intensity, it was administered in 18.3% of patients in dataset 1 and 2.3% in dataset 2. No FN or G-CSF-related adverse events were reported in patients who received adequate primary prevention.
Conclusion. Some issues related to G-CSF administration in cancer patients were identified. We identified the insufficient provision of patients with primary prevention of FN, which negatively affects survival rates and reduces adherence to antitumor therapy. Real-world data demonstrate the efficacy and safety of FN prevention and planned dose intensity maintance in cytotoxic therapy regimens.
HR repair pathway plays a crucial role in maintaining neural stem cell fate under irradiation stress
Authors: Xu Xiao , An Huanping , Wu Cheng , Sang Rong , Wu Litao , Lou Yuhan , Yang Xiaohang , Xi Yongmei
Published: May 2023

Environmental stress can cause mutation or genomic instability in stem cells which, in some cases, leads to tumorigenesis. Mechanisms to monitor and eliminate these mutant stem cells remain elusive. Here, using theDrosophilalarval brain as a model, we show that X-ray irradiation (IR) at the early larval stage leads to accumulation of nuclear Prospero (Pros), resulting in premature differentiation of neural stem cells (neuroblasts, NBs). Through NB-specific RNAi screenings, we determined that it is the Mre11–Rad50–Nbs1 complex and the homologous recombination (HR) repair pathway, rather than non-homologous end-joining pathway that plays, a dominant role in the maintenance of NBs under IR stress. The DNA damage sensor ATR/mei-41is shown to act to prevent IR-induced nuclear Pros in a WRNexo-dependent manner. The accumulation of nuclear Pros in NBs under IR stress, leads to NB cell fate termination, rather than resulting in mutant cell proliferation. Our study reveals an emerging mechanism for the HR repair pathway in maintaining neural stem cell fate under irradiation stress.
Culture Talk in Capitalist Realism: How We Talk about Culture and Why It's Important
Authors: Belozyorov Konstantin
Published: May 2023

The article is devoted to the study of the phenomenon of everyday practice of culture talk, the search for the most appropriate sociological optics for the study of this phenomenon. The core task of the article is to determine the heuristic potential of the synthesis of the theoretical approaches of Omar Lizardo and Mark Fisher in the context of the analysis of the social practice of culture talk. Particular attention is paid to the concept of "capitalist realism" proposed by Mark Fischer. The connection between capitalist realism and the phenomenon of culture talk, the specificity of the manifestation of capitalist realism in modern Ukrainian society, including in the political sphere, cultural transformations, and other social processes, is analyzed. It is emphasized that the study of the practice of culture talk cannot be limited exclusively to the communicative aspect, that this phenomenon requires a comprehensive study. The emphasis is made on those features of Omar Lizardo's concept that open up new opportunities for empirical analysis of the culture talk phenomenon within the framework of quantitative and qualitative sociological research. A critical analysis of the idea of Omar Lizardo is carried out, which presents culture talk as socialization, that is, communication that does not actualize the conflict and is capable of developing for its own sake. It is noted that the concept of "capitalist realism" takes the analysis of culture talk practice from the plane of a purely communicative aspect to the study of it as a space of political, cultural and social articulations of agents. It is proved that the phenomenon of culture talk contains elements of political, ideological, class discussions. Some examples of such discussions are given, which are typical for modern Ukrainian society. The possibilities of further scientific, including sociological, study of cultural consumption and aesthetic categories within the framework of the presented theoretical and methodological model, namely the synthesis of the theoretical developments of Omar Lizardo and Mark Fisher, are determined.
Maternal Practices and Identities: Temporal-Spatial Distribution
Authors: Kutyreva Vera , Lavoshnyk Julia
Published: May 2023

The article presents the analysis of maternal identities through the prism of the temporal-spatial distribution of everyday maternal practices. Markers are described by which women determine maternal identities, factors of their construction, patterns of the «ideal mother» and the spatio-temporal distribution of everyday motherhood practices in the context of women's determination of their maternal role. Theoretical and methodological approaches to the study of motherhood are analyzed, in particular, the possibilities of applying the activity-structural approach to the analysis of maternal identities and the relevance of the concepts of «care landscape», «ghettoization of motherhood», «temporal poverty» in the context of modern everyday motherhood practices. The application of the structural-activity concept allowed to analyze the daily practices of motherhood in time and space, and, accordingly, to identify the basic conditions for structuring the practices of motherhood of women with different family and work statuses. The paper emphasizes that maternal identities are not rigidly defined and provide opportunities to choose from a fairly wide range of cultural patterns, acting as a result of individual life projects. One of the main contradictions today is the contradiction between, on the one hand, the requirements of the labor market, the processes of individualization that lead to active involvement of mothers in employment and, on the other hand, the spread of «intensive» and «responsible» child-centered motherhood in modern parental culture. These practices are becoming more intense in terms of the time, attention, and effort that mothers put into caring for their children. The article concludes that such «intensive motherhood» acts as a substitute, compensatory mechanism for the functioning of the institution of fatherhood in an unsatisfactory (imperfect) socio-economic environment, as well as traditional for our society gender bias in favor of women in family responsibilities and parental functions.
Between Heroism and Marginality: Experiences of Mothers of Children with Intellectual Disabilities
Authors: Zaremba-Kosovych Hanna
Published: May 2023

The article is analyzed the experiences of mothers who gave birth to children with intellectual disabilities during the 1970s and 1990s in Ukraine. The topicality is determined by the fact that almost no similar research has been conducted in Ukraine. The novelty of the publication is that the context of disability policy in Soviet times and its impact on public perceptions of intellectual disability have not been analyzed. The theoretical and methodological basis of the study is the theory of social constructivism. The empirical research was conducted by qualitative methods: semi-structured in-depth interviews and ethnographic included observation in Kyiv, Lviv and Lviv region during 2019-2021. Due to the qualitative content analysis, a number of typical experiences were identified for mothers who already have adult children with intellectual disabilities: meeting with health professionals as bearers of symbolic power to exclude children with (intellectual) disabilities and their families from social space and social interactions, stigmatization of a child with a disability and his / her family, permanent care of a child with an intellectual disability, financial difficulties, rethinking the disability of a child and his / her motherhood in social activities and social inclusion.
Regional head elections, high-cost politics, and corruption in Indonesia
Authors: Agustino Leo , Hikmawan M Dian , Silas Jonah
Published: May 2023

Direct regional head elections or direct election give rise to two faces for Indonesian politics. On the one hand, a positive face towards democracy; on the other hand, it displays a negative impact. Its positive impacts include efforts to strengthen the political legitimacy of local governments; achieving political empowerment of citizens; institutionalizing checks and balances mechanisms between institutions in the region; and the emergence of female regional heads. Meanwhile, among the negative impacts of direct elections are the high costs of politics. The research presents a qualitative approach with data collection techniques in the form of literature studies, observations, and interviews. This paper marks aspects high costs were caused by several factors, such as candidacy buying, campaign costs, witness fees during the election, political consultant fees, and appeal fees to the Constitutional Court. Therefore, it is not surprising that the winning contestants will try to return to their capital by means of corruption. This research implies at least four modes of return of political capital exist for regional heads, namely: bribery in obtaining permits; buying and selling positions; bribes in the procurement of projects and goods; and manipulation of social assistance. Referring to this dilemma, it turns out that the election still leaves a huge amount of homework for deepening democracy in Indonesia.
The excellence scholarships program: Analysis of implementation aspects and societal impact
Authors: Kosasih Achmad , Juniarfa Nurzela Eka , Fadli Yusuf , Nurlukman Adie Dwiyanto , Basit Abdul
Published: May 2023

Education creates reliable and competitive people resources, which determines a nation's success. Scholarship policies have a substantial impact on the growth of a nation, particularly in terms of enhancing the quality of human resources and access to quality education. Open access to education can help establish an improved education system. The Excellence Scholarships Program is part of the Indonesian government's goal to produce trustworthy and competitive human resources. This research used a qualitative descriptive methodology by tracing official government documents associated with the Excellence Scholarships program. This report analyzes the 2019-2020 implementation and impact of Indonesia's main scholarship program.  This study examined program implementation using descriptive-qualitative research. According to the findings of this study, 2025 undergraduates won scholarships in the last two years. The procedures and aid distribution of the Excellence scholarship program are effective because they adhere to the predetermined flow and conditions, however, future improvements are required for the implementation of these scholarship programs: first, improving the principle of equal distribution of scholarship recipients to combat inequality, particularly in eastern Indonesia; and second, providing equal opportunities. This research also suggests further research could look into how the excellence scholarships program enhances scholarship recipients' quality of life and human resources.
Islamophobia as a religious-based horizontal conflict and its resolution
Authors: Pedrason Rodon , Handoko Waluyo , Setyoko Paulus Israwan , Kurniasih Denok
Published: May 2023

Islamophobia is a complex issue to discuss, starting from history, to the terrorist and extremist acts behind it. The definition of the term Islamophobia itself is studied to look at this issue from the point of view of conflict with two perspectives of perpetrators and victims as well. This also includes the influence of the media in herding opinions and disseminating them, as well as the Islamophobia Resolution established by the United Nations as an effort to counter this anti-Islamic sentiment. Islamophobia is included in the category of a dangerous circle where if the chain is not immediately broken, discrimination will continue to occur, leading to violence that results in victims. Alignment between racism and Islamophobia is also important in order to build a narrative that both views are prohibited. There is no single solution to combat Islamophobia, but several efforts can be made to build awareness and integrate Islamic values with universal humanity values, and the Islamophobia Resolution is one of the initiatives for that.
Public service transformation trough digital-based services during Covid-19 pandemic in Riau Province, Indonesia
Authors: Prihatin Panca Setyo , Amri Pahmi , Wicaksono Agung
Published: May 2023

The purpose of this paper is to show how the Riau Provincial Government might transform public services based on digital services in the direction of good governance. This paper then uses a qualitative analysis method with Nvivo 12 Plus as an analytical tool to visualize data from online media sites. The findings of this study indicate that during the Covid-19 pandemic, the transformation of digital service-based public services in Riau Province can be seen from three aspects, namely: First, on the transparency aspect, the Riau Provincial Government has implemented digital services so that they can be more easily accessed. Second, in terms of accountability, every public service provider already has a strong understanding of how to implement digital services. However, the implementation of digital services still faces challenges and requires improving aspects of internet network quality in several locations in remote and underdeveloped areas. Third, in terms of effectiveness and efficiency, the Riau Provincial Government has received various awards for public service innovations and has launched the Mata Bansos application which is intended to help communities affected by Covid-19. Therefore, this research contributes in the form of recommendations to continue to improve public services by utilizing existing digital service applications and further integrating public services that have not been integrated with digital-based services.
Mild solutions for semi-linear fractional order functional stochastic differential equations with impulse effect
Authors: Mohd Nadeem  , Jaydev Dabas
Published: May 2023

This paper is concerned with the existence results of mild solution for an impulsive fractional order stochastic differential equation with infinite delay subject to nonlocal conditions. The results are obtained by using the fixed point techniques and solution operator generated by sectorial operator on a Hilbert space.
Invariant solutions and conservation laws for a three-dimensional K-S equation
Authors: Reza Dastranj  , Mehdi Nadjafikhah  , Megerdich Toomanian
Published: May 2023

In this paper, we study three-dimensional Kudryashov-Sinelshchikov (K-S) equation, which describes long nonlinear pressure waves in a liquid containing gas bubbles. Firstly, We find the symmetry groups of the K-S equation. Secondly, using the symmetry groups, exact solutions which are invariant under a three-dimensional subalgebra of the symmetry Lie algebra are derived. Finally, by adding Bluman-Anco homotopy formula to the direct method local conservation laws of the K-S equation are obtained.
On semi-invariant submanifolds of a nearly trans-hyperbolic Sasakian manifold
Authors: Shamsur Rahman  , Arjumand Ahmad
Published: May 2023

Semi-invariant submanifold of a trans Sasakian manifold has been studies. In the present paper we study semi invariant submanifolds of a nearly trans hyperbolic Sasakian manifold. Nejenhuis tensor in a nearly trans hyperbolic Sasakian manifold is calculated. Integrability conditions for some distributions on a semi invariant submanifold of a nearly trans hyperbolic Sasakian manifold are investigated.
Super edge-antimagic graceful labeling of graphs
Authors: G. Marimuthu  , P. Krishnaveni
Published: May 2023

For a graph $G=(V, E)$, a bijection $g$ from $V(G) \cup E(G)$ into $\{1,2, \ldots,|V(G)|+|E(G)|\}$ is called $(a, d)$-edge-antimagic graceful labeling of $G$ if the edge-weights $w(x y)=|g(x)+g(y)-g(x y)|, x y \in E(G)$, form an arithmetic progression starting from $a$ and having a common difference $d$. An $(a, d)$-edge-antimagic graceful labeling is called super $(a, d)$-edge-antimagic graceful if $g(V(G))=\{1,2, \ldots,|V(G)|\}$. Note that the notion of super $(a, d)$-edge-antimagic graceful graphs is a generalization of the article "G. Marimuthu and $\mathrm{M}$. Balakrishnan, Super edge magic graceful graphs, Inf.Sci.287( 2014)140-151", since super $(a, 0)$-edge-antimagic graceful graph is a super edge magic graceful graph.We study super $(a, d)$-edge-antimagic graceful properties of certain classes of graphs, including complete graphs and complete bipartite graphs.
Hermite-Hadamard inequalities for L(j)-convex functions and S(j)-convex functions
Authors: Ilknur Yesilce  , Gabil Adilov
Published: May 2023

In this article, Hermite-Hadamard Inequalities for $\mathrm{L}(\mathrm{j})$-convex functions are analyzed. $\mathrm{S}(\mathrm{j})$-convex functions which is founded upon $\mathbb{B}^{-1}$-convexity concept, are defined and for this functions, Hermite-Hadamard Inequalities are investigated. On some special domains, concrete form of inequalities are denoted.
Graceful labeling of arrow graphs and double arrow graphs
Authors: V. J. Kaneria  , M. M. Jariya  , H. M. Makadia
Published: May 2023

In this paper we define arrow graph and double arrow graph. We also prove that arrow graphs $A_n^2, A_n^3, A_n^5$ are graceful and double arrow graphs $D A_n^2$ and $D A_n^3$ are graceful.
Research on Grid Planning of Dual Power Distribution Network Based on Parallel Ant Colony Optimization Algorithm
Authors: Wang Shuaixiang
Published: May 2023

A distribution network plays an extremely important role in the safe and efficient operation of a power grid. As the core part of a power grid’s operation, a distribution network will have a significant impact on the safety and reliability of residential electricity consumption. it is necessary to actively plan and modify the distribution network’s structure in the power grid, improve the quality of the distribution network, and optimize the planning of the distribution network, so that the network can be fully utilized to meet the needs of electricity consumption. In this paper, a distribution network grid planning algorithm based on the reliability of electricity consumption was completed using ant colony algorithm. For the distribution network structure planning of dual power sources, the parallel ant colony algorithm was used to prove that the premise of parallelism is the interactive process of ant colonies, and the dual power distribution network structure model is established based on the principle of the lowest cost. The artificial ants in the algorithm were compared with real ants in nature, and the basic steps and working principle of the ant colony optimization algorithm was studied with the help of the travelling salesman problem (TSP). Then, the limitations of the ant colony algorithm were analyzed, and an improvement strategy was proposed by using python for digital simulation. The results demonstrated the reliability of model-building and algorithm improvement.
Perfil clínico e epidemiológicos dos pacientes dermatológicos internados no Hospital Universitário de Teresina
Authors: Honorato de Queiroz Isabelly Cristina , Lopes Pádua Moura Carla Riama
Published: May 2023

INTRODUÇÃO: A dermatologia é uma especialidade predominantemente ambulatorial, no entanto, para um número significativo de paciente a internação é indispensável. Atualmente existem poucos estudos que permitam conhecer as particularidades e desfechos das internações dermatológicas, bem como orientar no cuidado das condições frequentemente encontradas no ambiente hospitalar. OBJETIVO: Caracterizar o perfil clínico, epidemiológico e a evolução dos pacientes internados pela especialidade da dermatologia. MÉTODOS: Foi realizada uma análise retrospectiva dos registros do prontuário eletrônico dos pacientes admitidos pela especialidade de dermatologia no HU-UFPI durante o período de janeiro de 2015 a dezembro de 2021 e preenchido instrumento de coleta elaborado pela autora. RESULTADOS: Foram analisados registros de 122 internações. A média de idade foi de 50,8 anos; gravidade da doença dermatológica e investigação foram motivos de admissão mais frequentes; 70,49% foi transferida de outro hospital; poucos pacientes foram considerados com indicação de isolamento; metade dos pacientes não possuía diagnóstico dermatológico previamente a internação; frequentemente os pacientes possuíam duas ou mais comorbidades (20,49%); anatomopatológico interno e exame clínico foram os principais recursos diagnósticos; a complicação mais frequente foi infecção hospitalar; 63,11% dos pacientes necessitaram de interconsulta e 20,49% foram transferidos para outras especialidades; 5,74% dos pacientes evoluíram com óbito.  CONCLUSÃO: O perfil evidenciado foi de pacientes na sexta década de vida, distribuição por sexo quase igualitária e com média de tempo de internação de 12 dias. Hanseníase e seus estados reacionais foram o diagnóstico mais frequente. A integração com outras especialidades foi importante e refletida no número de interconsulta e transferências.
A Latent Variable Analysis of Psychomotor and Neurocognitive Performance After Acute Cannabis Smoking
Authors: Smith Shelby , Wrobel Julia , Brooks-Russell Ashley , Kosnett Michael , Sammel Mary
Published: May 2023

Objective. This paper evaluated a novel, tablet-based neurocognitive and psychomotor test battery for detecting impairment from acute cannabis smoking using advanced quantitative methods. The study was conducted in a state with legal, recreational cannabis use and included participants who use cannabis occasionally or daily, and a no use comparison group. Methods. Participants completed a tablet-based test assessing reaction time, decision making, working memory and spatial-motor performance. The test was completed before and after participants smoked cannabis (or after a rest period in the case of controls). An Exploratory Factor Analysis approach was implemented to reduce dimensionality and evaluate correlations across the four assessed domains. Linear regression models were utilized to quantify associations between factor scores and cannabis use groups (daily vs. occasional vs. no use). Results. Seven factors were identified explaining 56.7% of the variance among the 18 measures. Regression models of the change in factors after cannabis smoking indicated those who use cannabis daily demonstrated poorer performance on a latent factor termed Displaced and Delayed (standardized coefficient 0.567, 95% CI: 0.178, 0.955; P = 0.005) compared to those with no use. Those who use cannabis occasionally exhibited a decline in performance on a latent factor termed Recall and Reaction (standardized coefficient 0.714, 95% CI: 0.092, 1.336; P = 0.025) compared to no use. Conclusions. This analysis demonstrates an innovative, quantitative approach to study how cannabis consumption affects neurocognitive and psychomotor performance. Results demonstrated that acute cannabis use is associated with changes in neurocognitive and psychomotor performance, with differences based on the pattern of occasional or daily use.
“That’s Pot Culture Right There”: Purchasing Behaviors of People Who Use Cannabis Without a Medical Cannabis Card
Authors: Gebru Nioud Mulugeta , Aston Elizabeth , Berey Benjamin , Snell L. Morgan , Leeman Robert , Metrik Jane
Published: May 2023

Introduction. The legal landscape surrounding purchasing cannabis without a medical cannabis card (i.e., without MCC) is changing rapidly, affecting consumer access and purchasing behaviors. Cannabis purchasing behaviors are related to subsequent use and experiencing greater cannabis-related negative consequences. However, purchasing behaviors of individuals who use cannabis without MCC are understudied. Methods. The current study analyzed qualitative data from focus groups with adults who use cannabis without MCC (n = 5 groups; 6-7 participants/group; n = 31 total participants). Focus groups followed a semi-structured agenda, and were audio recorded and transcribed. Two coders applied thematic analysis to summarize topics pertaining to cannabis purchasing attitudes and behaviors. Focus groups occurred in 2015 and 2016 in Rhode Island, when purchasing and use of cannabis without MCC was decriminalized but still considered illegal. Results. On average, participants (72% male) were 26 years old (SD = 7.2) and reported using cannabis 5 days per week (SD = 2.1). Thematic analysis revealed three key themes related to cannabis purchasing behaviors: (1) regular purchasing routines (i.e., frequency, schedule, amount of purchases), (2) economic factors (i.e., financial circumstances), and (3) contextual factors (i.e., quality of cannabis, convenience/availability) were perceived to influence purchasing decisions. Dealers’ recommendations affected participants’ purchases, who also reported minimal legal concerns. Participants reported saving money and using more cannabis when buying in bulk. Discussion. Purchasing behaviors were found to vary and were perceived to be affected by individual-level (e.g., routines) and contextual factors (e.g., availability) that, in turn, may impact use patterns. Future research should consider how factors (e.g., availability) that differ across contexts (e.g., location) and demographic groups interact to affect purchasing behaviors.
Pengaruh Pengetahuan, Sikap dan Perilaku Masyarakat Tehadap Kegiatan Urban Farming
Authors: Ulfa Tenri , Pertiwi Nurlita
Published: May 2023

This study describes the behavior of urban farming (UFB) in the people of Makassar City and the factors that influence it. The selection of locations and respondents was based on residential areas located in the city center and in areas outside the city with the community carrying out urban farming activities, as many as 50 respondents. The type of research is descriptive quantitative and correlational using a questionnaire instrument analyzed with descriptive statistical techniques and a comparison test with Kendall's test. The results of the study indicate that respondents generally have high environmental knowledge, while respondents' environmental attitudes are in the moderate category. The reasons for urban farming as a lifestyle were revealed to 27 respondents with high urban farming behavior. Meanwhile, there were 23 respondents with low urban farming activities who revealed the difficulties in implementing urban farming due to time constraints. The results of statistical analysis show that there is a significant (significant) relationship, which is strong and unidirectional in all of the good relationships between knowledge and attitudes, knowledge with behavior and attitudes with behavior, this means that the higher knowledge will affect the attitudes and behavior of respondents, so also with a change in attitude will have an impact on the behavior of respondents in terms of carrying out urban farming activities.
PENGARUH PENGETAHUAN LINGKUNGAN DAN LOCUS OF CONTROL TERHADAP PERILAKU MENANAM JATI PETANI DI KABUPATEN BUTON SELATAN
Authors: Sahirsan Sahirsan , Muzaki Muzaki
Published: May 2023

Pemeliharaan hutan jati di Kabupaten Buton Selatan merupakan kebiasaan yang turun temurun. Namun demikian perilaku ini menjadi tergantikan dengan aktivitas ekonomi yang cenderung menghilangkan tanaman jati. Kajian ini berfokus pada upaya menemukan pengaruh pengetahuan dan locus of control terhadap perilaku penanaman jati petani di Kabupaten Buton Selatan. Penelitian ini berlangsung Pada bulan Juni - Juli 2021 Di Kecamatan Batauga yang melibatkan 120 petani. Analisis data kuantitatif dilakukan dengan metode deskriptif dan statistik. Hasil penelitian menunjukkan bahwa pengetahuan lingkungan berpengaruh terhadap perilaku penanaman jati, sedangkan locus of control tidak memberikan pengaruh terhadap perilaku tersebut.
Peningkatan Pengetahuan dan Sikap Terhadap Pengelolaan Sampah Pada Anak Putus Sekolah Melalui Pelatihan Pembuatan Pupuk Organik
Authors: Asrinda Asrinda , Hasan Irwan Syah Nur , Khalizah Andi Nurul , Pertiwi Nurlita
Published: May 2023

Organic waste management is an effort to reduce the volume of waste. This effort can be done easily by the community with simple technology. This article reveals efforts to increase knowledge and attitudes of school dropouts through training in the manufacture of organic fertilizers. This research is a quantitative research with a quasi-experimental approach. The subjects of the training are school dropouts who live around the Pasar Daya, Makassar City and worked part time as foster workers. The number of training subjects was 15 people who were trained for eight meetings with demonstration techniques and assistance in the use of tools. The results showed that there was an increase in knowledge and attitudes of organic waste management in school dropouts after attending training.Abstrak.Pengelolaan sampah organik merupakan upaya mereduksi volume sampah. Upaya ini dapat dilakukan secara mudah oleh masyarakat dengan teknologi yang sederhana. Artikel ini mengungkapkan upaya peningkatan pengetahuan dan sikap pada anak putus sekolah melalui pelatihan pembuatan pupuk organik. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan quasi eksperimen. Subjek pelatihan adalah anak putus sekolah yang bermukim di sekitar Pasar Daya Kota Makassar dan bekerja paruh waktu sebagai buruh angkat. Jumlah subjek pelatihan sebanyak 15 orang yang dilatih selama delapan kali pertemuan dengan teknik demonstrasi dan pendampingan penggunaan alat. Hasil penelitian menunjukkan bahwa terdapat peningkatan pengetahuan dan sikap pengelolaan sampah organik pada anak putus sekolah setelah mengikuti pelatihan.
Analisis Perangkat Pembelajaran Membaca Permulaan Berbasis Metode Steinberg Yang Praktis Di Sekolah Dasar
Authors: Kasmawati Kasmawati , La Sisi La Sisi , Juwairiyah Arna , Parizu Chairan Zibar L
Published: May 2023

Tujuan penelitian ini yaitu untuk mengetahui, menjelaskan, memaparkan, dan mengembangkan perangkat pembelajaran yang digunakan dalam proses membaca permulaan berbasis metode Steinberg yang efektif di sekolah dasar. Pengembangan perangkat pembelajaran membaca permulaan dalam penelitian ini mengacu pada Model Thiagarajan Model 4-D. Model ini terdiri atas 4 (empat) tahap pengembangan yaitu define, design, develop, dan desseminate atau diadaptasikan menjadi Model 4-P, yaitu pendefinisian, perancangan, pengembangan, dan penyebaran yang dimodifikasi langkah-langkahnya pada tahapan define.  Subjek penelitiannya yaitu perangkat pembelajaran membaca permulaan berupa silabus, RPP dan bahan ajar yang akan dikembangkan. Data penelitian berupa data kualitatif. Teknik pengumpulan data menggunakan observasi, dan wawancara. Teknik analisis data menggunakan analisis kualitatif.Hasil penelitian menunjukan bahwa seluruh peserta didik yakni 28 orang yang terdiri dari 10 laki-laki, 18 perempuan,  yang mengikuti pembelajaran dengan menggunakan perangkat pembelajaran membaca permulaan berbasis metode Steinberg meningkat kemampuannya dalam membaca permulaan dengan persentase  antara 10–88 persen. Rata-rata kemampuan membaca permulaan pada pretes mencapai 51,4% sedangkan pada postes mencapai 71,3%.Kesimpulan penelitian ini yaitu Seluruh peserta didik yang mengikuti pembelajaran dengan menggunakan perangkat pembelajaran membaca permulaan berbasis metode Steinberg meningkat kemampuannya dalam membaca permulaan. Pengembangan perangkat pembelajaran membaca permulaan Berbasis Metode Steinberg sangat dibutuhkan guna meningkatkan kualitas proses pembelajaran membaca permulaan di kelas I.
Persepsi dan Sikap Masyarakat Terhadap Pemanfaatan Limbah Ternak Menjadi Biogas dan Biofertilizer di Desa Laikang Kecamatan Mangarabombang Kabupaten Takalar
Authors: Alam Sahrul , Rustan Nurul Azisah Maharani , Anggraini Putri , Mandra Moh Ahsan S , Ali A. M. Taufik
Published: May 2023

Penelitian ini merupakan survei awal untuk mengetahui persepsi dan sikap masyarakat terhadap pemanfaatan limbah ternak menjadi energi alternatif biogas dan biofertilizer yang akan diterapkan pada Program Holistik Pembinaan dan Pemberdayaan Desa (PHP2D). Pemanfaatan limbah ternak dapat memberikan nilai tambah dan peningkatan ekonomi masyarakat serta menjaga kelestarian lingkungan. Metode pengambian data menggunakan wawancara terstruktur selanjutnya dilakukan analisis dengan teknik persentase. Hasil penelitian menunjukkan bahwa pemanfaatan limbah ternak melalui penerapan teknologi biogas dan biofertilizer umunya belum diterapkan di masyarakat Desa Laikang. Persepsi masyarakat terhadap penerapan teknologi pemanfaatan limbah ternak umumnya sangat setuju dan tertarik untuk menerapkan teknologi biogas dan biofertilizer. Sikap masyarakat juga cenderung tinggi mendukung program penerapan teknologi, bersedia aktif dalam kegiatan penyuluhan dan pelatihan, serta bersedia menjadi mitra program pemberdayaan masyarakat melalui pengelolaan limbah ternak menjadi biogas dan biofertilizer.
PENGARUH PENGGUNAAN VIDEO EDUKASI PENGELOLAAN DAN PENANGANAN SAMPAH TERHADAP SIKAP SISWA SEKOLAH DASAR DI KOTA MAKASSAR
Authors: Kurniawan Anis , Gani Hamsu Abdul , Sahabuddin Erma S.
Published: May 2023

This study aims to determine the knowledge and attitudes of SD Negeri Borong Makassar students in managing and handling waste in the school environment. This research is a quantitative research with a correlational approach with one group pretest posttest design. The population in this study were all students of Class V and Class VI. The sample collection technique uses saturated sampling or the entire population is used as a sample. The data collection technique of this research is using tests, questionnaires and direct observation in the field. The data were then analyzed using descriptive statistics and T test with the help of SPSS 21.0. The results showed that the knowledge and attitudes of Class V and Class VI students before and after receiving environmental education video-based learning experienced a significant increase based on a descriptive analysis of the value of students' knowledge and attitudes after being given an educational video in the very high category regarding waste management and handling in the environment. school.
HUBUNGAN POSTUR KERJA DENGAN KEJADIAN MYALGIA PADA PETANI DI KECAMATAN BUNGAYA KABUPATEN GOWA
Authors: Azis Putri , Juhanto Asrijun , Rahmawati Rahmawati
Published: May 2023

Complaints of muscle pain are symptoms in the body that are often suffered by humans which are characterized by the appearance of pain or aching, heaviness, stiffness in the muscles. Work that is carried out for a long time and is accompanied by the use of inappropriate body postures and can pose a risk of interference with the muscles in doing work, including standing, sitting, squatting, bending, walking which can result in myalgia. The purpose of this study was to determine the relationship between work posture and the incidence of myalgia in farmers in Bungaya District, Gowa Regency. This research is a quantitative study with a cross sectional study approach. The total population in the study was 101 farmers. The sampling technique in this study used the Slovin Formula with a total sample of 51 samples selected. Data were analyzed by chi-square test α (0.05). The research results obtained statistically showed that there was a relationship between knowledge (p-values = 0.027) and length of work duration (p-value = 0.000) with Myalgia Incidence, while age (p-values = 0.514) and work posture (p-values = 0.351) there is no relationship with the incidence of myalgia. The conclusion of the research results shows that there is a relationship between knowledge and length of work with the incidence of myalgia, and there is no relationship between age and work posture with the incidence of myalgia. It is hoped that the public can pay attention to the position when working, especially the duration of work when working no more than 8 hours/day.
PENGARUH SIKAP SISWA TERHADAP KEPEDULIAN PADA LINGKUNGAN DI MADRASAH ALIYAH MUHAMMADIYAH LIMBUNG KABUPATEN GOWA
Authors: Aminah Aminah , Yermi Yermi
Published: May 2023

Aminah. The Effect of Students' Attitudes on Concern for the Environment at Madrasah Aliyah Muhammadiyah Limbung, Gowa Regency. This study aims to determine the effect of students' attitudes on concern for the environment at Madrasah Aliyah Muhammadiyah, Gowa Regency. This type of research is a survey. Data was collected using a questionnaire. The sample in the study was 67 people. The data were analyzed using descriptive and inferential analysis. The results of the analysis show that: (1) the attitude and concern of students towards the environment at Madrasah Aliyah Muhammadiyah Limbung Gowa Regency is in the high category. (2) there is a positive influence on students' attitudes towards students' environmental concerns at Madrasah Aliyah Muhammadiyah Limbung Gowa Regency, with a regression coefficient of 0.408 meaning that if students' attitudes are improved it will have a positive effect on environmental awareness of 0.408 from the magnitude of the increase in student.
PERILAKU PENGELOLAAN SAMPAH MEDIS PADAT DI RUMAH SAKIT UMUM LABUANG BAJI KOTA MAKASSAR
Authors: Juhanto Asrijun , Hadijah Hadijah , Yusuf Andi
Published: May 2023

Medical waste is a type of hazardous waste because it comes from equipment that has the potential to contain infectious agents, toxic and radioactive materials. Many studies suggest that every individual who is involved or interacts with the hospital environment is very vulnerable to exposure to medical waste. Quantitative research method with a cross-sectinal study approach with a total sample of 31 cleaning staff at Laburan Baji Hospital, Makassar City. Data collection was distributed to respondents who were on duty at the time of the study. The results showed that the knowledge of respondents was significantly related to solid medical waste management ρ=0.000 < α=0.05. Respondents' attitudes are significantly related to medical waste management with a value of ρ=0.001 < α=0.05. Respondents' actions were significantly related to solid medical waste management with a value of ρ=0.011<α=0.05. Respondent's skills are not significantly related to solid medical waste management with a value of ρ=0.083> α=0.05. Provision of PPE for respondents was not significantly related to solid medical waste management with a value of ρ=0.074 > α=0.05. The most influential variable is the knowledge of the respondents with Exp(B) value of 57.679. It is expected that cleaning staff will always comply with the rules that have been given to cleaning workers so that they can avoid incidents of being contaminated with medical waste in hospitals.
PENGARUH KOMPETENSI GURU TERHADAP KARAKTER SISWA PADA LINGKUNGAN DI SD ISLAM ATHIRAH BUKIT BARUGA MAKASSAR
Authors: Aminah Aminah , Fatmawati Fatmawati , Yermi Yermi , Syamsul Musdalifah
Published: May 2023

This study aims to determine the effect of teacher competence on student character in the environment at SD Islam Athirah Bukit Baruga Makassar. This type of research is a survey. Data was collected using a questionnaire. The sample in the study was 42 people. The data were analyzed using descriptive and inferential analysis. The results of the analysis show that: (1) teacher competence in managing learning and student character in the environment at SD Islam Athirah Bukit Baruga Makassar is in the high category, and (2) there is a positive influence of teacher competence on student character in the environment at SD Islam Athirah Bukit Baruga Makassar, with a regression coefficient of 0.867 means that if teacher competence is increased it will have a positive effect on student character in the environment of 0.867 of the magnitude of the increase in teacher competence.