bluuebunny/crossref_metadata_2025 huggingface dataset:
Maintenance of Clinical Response With Continued Risankizumab Treatment for Moderate-to-Severe Psoriasis Through 304 Weeks: Interim Analysis of the LIMMitless Open-Label Extension Study
Authors: Lebwohl Mark , Bachelez Hervé , Gordon Kenneth , Wu Tianshuang , Chen Michael , Kaplan Blair , Papp Kim
Published: November 2023

Introduction: Interleukin (IL)-23 is a key regulator of plaque psoriasis pathogenesis. Risankizumab, a humanized immunoglobulin G1 monoclonal antibody that specifically inhibits IL-23 by binding to its p19 subunit, is approved for the treatment of moderate-to-severe plaque psoriasis in adults; however, additional data on long-term maintenance of efficacy with risankizumab treatment are needed. Here we report on the maintenance of clinical response through 304 weeks of continuous risankizumab treatment.

Methods: In this interim analysis, we evaluated patients with moderate-to-severe plaque psoriasis who were randomized to receive risankizumab 150 mg at weeks 0, 4, and 16 and every 12 weeks thereafter during 2 double‑blind, phase 3, 52-week base studies (UltIMMa 1 [NCT02684370] and UltIMMa 2 [NCT02684357]) and enrolled in LIMMitless, an ongoing, phase 3, multicenter, single‑arm, open-label extension (OLE) study (NCT03047395) evaluating the long-term safety and efficacy of continuous risankizumab 150 mg treatment every 12 weeks for plaque psoriasis. Safety was assessed through ≤ 324 weeks by monitoring of treatment‑emergent adverse events through the data cutoff date (May 22, 2023). Efficacy was assessed by the proportion of patients who maintained ≥ 90% or 100% improvement from baseline in Psoriasis Area and Severity Index (PASI 90/100) during LIMMitless and mean improvement in PASI from baseline of the UltIMMa-1/2 study through 252 additional weeks in the LIMMitless study (total of 304 weeks). Missing efficacy data were imputed using modified nonresponder imputation (mNRI), last observation carried forward (LOCF), or observed cases (OC) methodology.

Results: A total of 525 patients were randomized to receive risankizumab 150 mg treatment for 52 weeks in the UltlMMa‑1/2 studies and continued open-label risankizumab 150 mg treatment in the LIMMitless OLE study. Risankizumab was well tolerated through ≤ 324 weeks; no new safety concerns were reported in patients with moderate-to-severe plaque psoriasis. At OLE entry, most patients (451, 85.9%) achieved PASI 90; of those, 422 (93.6%) maintained PASI 90 through week 304 by mNRI (LOCF, 92.7%; OC, 93.8%). Of 320 patients (61.0%) who achieved PASI 100 at OLE entry, 209 (65.3%) maintained PASI 100 through week 304 by mNRI (LOCF, 80.6%; OC, 79.9%). Mean PASI improvement from baseline was generally consistent from OLE entry (95.6% for both LOCF and OC) through week 304 (LOCF, 95.9%; OC, 96.5%).

Conclusion: In this 304-week interim analysis of continuous risankizumab treatment, the safety profile was consistent with previous interim analyses from the LIMMitless study. With continuous risankizumab treatment, most patients maintained PASI 90 or PASI 100 responses from OLE entry through 252 additional weeks in the LIMMitless study.
Searching for and warning people in buildings in case of fires and emergencies via wireless Wi-Fi network
Authors:   State Fire Academy of EMERCOM of Russia, Antonov Sergey V. , Butko Vyacheslav S. ,   State Fire Academy of EMERCOM of Russia, Zykov Vladimir I. ,   State Fire Academy of EMERCOM of Russia
Published: November 2023

PURPOSE. The article discusses issues of searching for people in a burning building and monitoring compliance with evacuation rules to a refuge area. In case of fires or other emergencies in buildings evacuating people from technical rooms is a great concern. Management information system (MIS) model for warning of emergency in building has been worked out to solve this problem. The article is aimed at substantiating radio channel system use for searching for people during fires and emergencies via wireless Wi-Fi network. METHODS. Mobile device transmits signal powers from nearby Wi-Fi routers to the building MIS server. Based on information about routers placement points and order, it is possible to locate a person if his phone transmits only residual signal power in a given location. Statistical model ITU-R 1238 is used to calculate power loss. All signal power level matrices at receiver input from routers at the person’s location are constructed, compared with signal power matrix at the device location, and mobile device exact location is determined. Dividing room into cubes makes it possible to determine a person’s position – standing or lying. FINDINGS. Mandatory requirement for searching for people in buildings system functioning is using a two-way radio channel (via wireless Wi-Fi network), which can significantly expand fire alarm system functionality in terms of constant serviceability monitoring. RESEARCH APPLICATION FIELD. It is advisable to include research results in research and development work of EMERCOM of Russia and other ministries and departments research organizations involved in developing fire safety systems for critical protection facilities. CONCLUSIONS. Developing radio channel system for searching for people in emergencies will make it possible not only to locate technical personnel with mobile devices, but to evacuate people if necessary.
Comparative analysis of methods for determining maximum dimensions of explosive zones
Authors:   State Fire Academy of EMERCOM of Russia, Bobyreva Tatyana N. , Grokhotov Mikhail A. ,   State Fire Academy of EMERCOM of Russia, Voloshenko Aleksey A. ,   State Fire Academy of EMERCOM of Russia, Feschenko Aleksander N. ,   State Fire Academy of EMERCOM of Russia
Published: November 2023

PURPOSE. Existing regulatory methods for determining the maximum dimensions of explosive zones when flammable gases leak from process equipment do not fully reflect the physical picture of the accident. The purpose of the work in question is to compare existing methods for determining the maximum dimensions of explosive zones. To achieve the goal, the following tasks were solved: an analysis of existing methods for determining the maximum dimensions of explosive zones was carried out; an emergency situation associated with propane leak into open space was simulated in the PyroSim software package. The object of the study is the leakage of flammable gases from process equipment during accidents. The subject of the study is to determine maximum dimensions of explosive zones in case of flammable gases leakage from process equipment during accidents. METHODS. To evaluate existing methods for determining the maximum dimensions of explosive zones, regulatory documents were analyzed. To simulate an emergency situation associated with a propane leak into open space, PyroSim software package was used. FINDINGS. The given study examines accidents related to flammable gases emission into open space. The analysis of emergency situations at the facilities related to the circulation of flammable gases showed that when process equipment depressurizes, in most cases, gas leaks into the environment rather than instantaneously releases. RESEARCH APPLICATION FIELD. The outcomes of the study can be used to improve the methodology for determining maximum dimensions of explosive zones as a result of an emergency situation related to flammable gases emission into open space. CONCLUSIONS. When comparing the calculations outcomes to determine geometric dimensions (radius and height) of an explosive zone using methods from the regulatory documents, it was found out that the values of geometric dimensions of a gas cloud have a significant discrepancy, and the results according to these methods are correct to be used for an instantaneous gas release, and not for gas leakage from process equipment. Numerical modeling will make it possible to determine maximum dimensions of explosive zones of flammable gases in open space during leakage from process equipment more accurately, taking into account physic-chemical properties of flammable gas and environmental parameters.
Statistical analysis and modeling data on eliminating fires at fuel and energy enterprises
Authors:   Mytischi Branch of Bauman Moscow State Technical University, Vilisov Valery Ya. , Khabibulin Renat Sh. ,   State Fire Academy of EMERCOM of Russia
Published: November 2023

PURPOSE. Using the example of statistical data on fires at fuel and energy enterprises for the period from 2000 to 2020, stored in the federal database “Fires”, an algorithm for these data statistical analysis is proposed for constructing a statistical digital twin (SDT) of the type of fires under consideration. The SDT under development is aimed at creating any necessary and adequate to the initial data sample set of records (dataset) for the simulated class of fires for subsequent modeling and other studies. The objectives of this work are the construction of an algorithm and the study of the main key points in constructing the SDT. The object of the study is a set of fires, whose characteristics are enclosed contained in the form of separate records in the database, while the subject of the study is a set of statistical static and dynamic models that should be built on the basis of these data analysis. METHODS. Methods of probability theory, mathematical statistics, simulation modeling and statistical estimation are used. An approach based on the joint use of the Monte Carlo method and bootstrap principles to form adequate training samples is proposed. FINDINGS. MCB-modeling algorithm (Monte Carlo bootstrap) is proposed for generating a statistical sample of data on fires in the amount necessary for machine learning of a wide class of decision support models. The relevance of the proposed approach is due to the fact that in some cases the available statistics are insufficient in volume for building decision support models and other studies. RESEARCH APPLICATION FIELD. SDT, built on the basis of MCB-modeling, will allow forming data samples of the required volume, which are similar to the original databases. CONCLUSIONS. The application of the proposed algorithm for constructing SDT for MCB-modeling will allow building machine-learning models for their use as part of decision support systems in safety systems.
THE DISCOURSE OF SPIRITUAL AND EXISTENTIAL FORMATION OF IVAN FRANKO: THE CONCEPT OF PERSONALITY
Authors: ZYMOMRYA Mykola , YAKUBOVSKA Mariia
Published: November 2023

The review of the monograph by Y. Nakhlik “Virazhi Frankovoho Dukhu Svitohliad.

Ideolohiia. Literatura” examines the system of innovative changes in the field of contemporary Franco`s studies through the widening of different discourses (cultural studies, philosophy, literature, education, and upbringing). It is proved that the basis of the study is a straight-through model of the spiritual-existential formation of the evolutionary progress of Ivan Franko, which is human-centric, national-centric. The problems, which are revealed in the monograph as the basis of spiritual and moral development and self-development, are investigated and analyzed. The guidelines for reflection of the formation of the self-challenge component in the system of formation of spiritual and moral values in the system of personality`s and society`s interaction are emphasized. The role of artwork as a system of aesthetic, philosophical, psycholinguistic values is examined on the sample of the analysis of the main thematic layers of the monograph.

The analysis of peer-reviewed monograph argues that the text as a basis for cultural studies is an all-encompassing phenomenon. SynergeticsFranko`s texts covers all areas of human activity. In their system archetypes codes generated significant era. The set of ideals and symbols, norms and principles, achievements, and values influences on the organization life, and how human activity both in material and in spiritual spheres.

Based on the analysis of the artistic heritage of Ivan Franko is a redefining primitive interpretation of artistic phenomena. These processes are the basis for the formation of a new system of thinking, a new human individuality, and new, high-quality human relations. Ivan Franko`s creative work shows that humanity's means of cultural influence is moving from one era to another era of technocracy to assert religious moral values. In the past pragmatism and away technocrats, the humancentric model is a cross-cutting social life of mankind.

By analyzing the Ivan Franko`s works we see expanding intellectual horizons of literature and social life. A literary text is a basic for foundation of the person's world. Tradition of Franco's words have continued through time and space. The World cultural system is currently undergoing a major transformation in the party establishment moral values of our time. In contrast, selfishness, greed, callousness, indifference practice life brings to life the circulation of qualitatively new values: sacrifice, forgiveness, understanding the world, another human civilization.

The presented monograph is analyzed in light of the system of axiological values of the cultural paradigm. The study of Ivan Franko's spiritual evolution provides a systematic analysis of the importance of the text in the philosophical and existential rendition of the epoch.
Effect of Return On Assets, Return On Equity, and Current Ratio on Stock Returns
Authors: Rachmawati Windasari , Ulya Naufal , Karim Abdul
Published: November 2023

The performance of a financial company can affect stock prices where stock prices sometimes experience increases and decreases. The stock price is very influential on stock returns for investors. This study aims to analyze the effect of the independent variables on the dependent variable. The independent variables in this study are Return On Assets, Return On Equity, and Current Ratio. While the dependent variable in this study is stock returns. The population in this study are food and beverage sub-sector manufacturing companies listed on the Indonesia Stock Exchange in 2018-2021. The sample selection in this study used a purposive sampling method and obtained a sample of 27 based on certain criteria. The data analysis technique used is multiple linear regression analysis using SPSS 22. The result of this study is significance value of the variabel Return On Assets is 0,099 > 0,05, variable Return On Equity is 0,950 > 0,05, and variable Current Ratio is 0,153, so hyphotesis is rejected. The conclusion of this study that Return On Assets, Return On Equity, and Current Ratio have no significant effect on stock returns.

Keywords : Return On Assets, Return On Equity, Current Ratio, stock returns.
Analysis of The Effect of Service Quality, Product Quality, and Price on Customer Satisfaction on CV SMART
Authors: Susanto Susanto , Pratama Mohammad Vicky , Pradiptya Adhi
Published: November 2023

This study aims to analyze the effect of service quality,product quality and price on customer satisfaction at Cv smart semarang.  This research was conducted using quantitative methods. The number of research samples was 96 respondents who were consumers of cv smart semarang. The technique used in this study using purposive sampling technique. Quantitative analysis results include validity test,reliability test,classic assumption test (normality test,heteroscedasticity test and multicollinearity test), multiple linear regression test and the last hypothesis test using the T test, F test and the coefficient of determination (R2).  The research results show that service quality, product quality and price have a positive and significant. With the following regression equation Y = 0,222 X1+0,284 X2+0,391 X3. And the magnitude of the coefficient of determination (R2) is 0,609 which means 60,9 percent of consumer satisfaction is influenced by service quality,product quality,and price.

 
Kualitas Mie Basah dengan Substitusi Tepung Bonggol Pisang Kepok (Musa acuminata balbisiana C.) dan Umbi Bit (Beta vulgaris L.)
Authors: Liya Hertanti Beatrik , Pranata Franciscus Sinung , Reni Swasti Yuliana
Published: November 2023

Noodle is a popular food and mostly consumed by people in Indonesia. The addition of kepok banana corm and beetroot flour as potential local foodstuff is expected to increase nutritional content, especially fibre content in wet noodle product. This research aims to determine the effect of substitution of kepok banana corm and beetroot flour on the physical, chemical, microbiological, and organoleptic qualities of wet noodle, and to determine the best substitution ratio of kepok banana corm and beetroot flour to produce wet noodle with the best quality. This research used a completely randomised design with four treatments are control treatment (100:0:0), A (70:10:20), B (70:15:15), and C (70:20:10) with three repetitions. The results of this research are wet noodles have moisture content of 54,59-62,80%, ash content of 0,79-1,16%, protein content of 3,53-6,60%, insoluble fibre content of 7,81-9,50%, soluble fibre content of 4,84-10,82%, fat content of 2,43-6,48%, carbohydrate content of 25,99-35,56%, and water absorption of 37,38-43,86%. The results of microbiological analysis of wet noodles are ALT 0,43 x 102  to 11,73 x 102 () and AKK 0,08 x 102  to 0,26 x 102 (). The best quality of wet noodle is treatment C based on chemical, physical, microbiological, and organoleptic parameters
Karakteristik Fisik Komposit Biopolimer Sebagai Alternatif Gelatin
Authors: Aprianti Gustira Endah , Edhi Suyatma Nugraha , Arpah Muhammad
Published: November 2023

Gelatin memiliki peranan yang sangat penting bagi industri. Pembuatan gelatin menggunakan kulit dan tulang babi atau sapi yang bisa menimbulkan masalah bagi umat islam, hindu, yahudi dan vegetarian. Upaya yang dapat dilakukan mengatasi hal tersebut yaitu dengan mencari bahan baku lain sebagai alternatif gelatin. Tujuan dari penelitian ini untuk mengetahui karakteristik fisik komposit biopolimer dan untuk mengetahui formula komposit biopolimer terbaik sebagai alternatif gelatin. Biopolimer yang digunakan adalah kappa karagenan, pati termodifikasi, CMC, dan isolat protein kedelai. Beberapa analisis yang dilakukan diantaranya pembentukan gel, efek pengental, pembentukan film, transparansi gel, sineresis, kelarutan dalam air dingin, dan kekutan gel. Uji statistik yang digunakan yaitu uji Dunnett dengan taraf signifikansi 5%. Hasil yang tidak berbeda nyata dengan gelatin akan dipilih sebagai komposit biopolimer terbaik. Komposit biopolimer terbaik terdiri dari kappa karagenan, pati termodifikasi, dan isolat protein kedelai. Berdasarkan uji kekuatan gel, formula komposit biopolimer yang tidak berbeda nyata dengan gelatin adalah K3I4C0, K3P3I1 dan K3P4I0.
PENGARUH MOTIVASI, DISIPLIN, DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN PT. APF, TBK.
Authors: Nurhidayah Siti Abdillah , Lestari Dyah Putri , Putra Gilang Kharisma
Published: November 2023

Era globalisasi, persaingan dalam dunia bisnis sangat cepat, sehingga organisasi dituntut untuk terus bekerja dengan keseriusan untuk mengimbangi daya saing organisasi yang sebenarnya. Kemampuan untuk mengoptimalkan SDM dan manajemen SDM sangat penting untuk setiap bisnis, termasuk pada PT. Asia Pacific Fibers (APF), Tbk. Sehingga, perlu penelitian ini perlu dilakukan untuk mengetahui variabel apa saja yang mampu berpengaruh terhadap kinerja karyawan. Penelitian ini dimaksudkan untuk mencari tahu sejauh mana dampak motivasi kerja, disiplin kerja, serta lingkungan kerja pada kinerja karyawan. Metode kuantitatif digunakan dalam penelitian ini. Data yang digunakan berupa data primer dengan cara menyebarkan kuesioner kepada karyawan bagian texturizing. Dimana populasinya adalah 133. Sedangkan sample yang digunakan adalah 100 responden. Metode sampling menggunakan purposive sampling. Pada penelitian ini data dikumpulkan menggunakan kuesioner dan diproses dengan SPSS 26. Temuan menunjukkan t motivasi kerja berdampak terhadap kinerja karyawan senilai 2.924. Secara langsung disiplin kerja berdampak terhadap kinerja karyawan senilai 4.867. Secara langsung lingkungan kerja berdampak terhadap kinerja karyawan senilai 2.926. Secara bersama-sama motivasi kerja, disiplin kerja, dan lingkungan kerja memiliki dampak terhadap kinerja karyawan senilai”31.302. Hasil Adjusted R2 senilai 0,479 menunjukkan besarnya pengaruh dari 3 variabel bebas secara bersama-sama senilai 47,9% dan sisanya senilai 52,1% merupakan variabel lain selain dalam penelitian ini.
Faktor-faktor yang Mempengaruhi Kinerja Karyawan di PT. Ebako Nusantara
Authors: Shofiana Vicky Nesriyan Dewi , Souisa Johanis , Oktavianto Alvian Dwi
Published: November 2023

Kinerja karyawan menjadi salah satu aspek sangat penting dalam perusahaan. Kinerja seorang karyawan dipengaruhi oleh beberapa faktor antara lain yaitu Motivasi, Disiplin, dan Lingkungan Kerja. Penelitian ini bertujuan untuk mengetahui pengaruh Motivasi, Disiplin, dan Lingkungan Kerja terhadap Kinerja Karyawan PT. Ebako Nusantara. Penelitian ini menggunakan metode penelitian kuantitatif. Populasi dalam penelitian ini adalah seluruh karyawan PT. Ebako Nusantara yang berjumlah 700 orang. Dalam pengambilan sampel menggunakan teknik Probability sampling yaitu dengan menggunakan teknik simple random sampling. Sampel dalam penelitian ini berjumlah 88 responden. Metode pengumpulan data penelitian ini yaitu metode survei dengan kuesioner sebagai alat pengumpulan datanya. Penelitian ini menggunakan analisis berganda sebagaai metode analisisnya. Data diolah menggunakan SPSS (Statistical Program for Social Science) versi 25. Hasil penelitian menunjukan bahwa variabel independen Motivasi Kerja (X1), Disiplin Kerja (X2), dan Lingkungan Kerja (X3) berpengaruh positif dan signifikan terhadap variabel dependen Kinerja Karyawan (Y) PT. Ebako Nusantara.
Skrining Diabetes Mellitus Melalui Pemeriksaan dan Konsultasi Hasil Gula Darah di Rumah Pelayanan Sosial
Authors: Purnamasari Rina , Rakhmawatie Maya Dian , Diatri Devita , Rohmani Afiana
Published: November 2023

Latar belakang: Diabetes mellitus (DM) adalah penyakit tidak menular yang ditandai dengan kadar gula darah melebihi normal. Cara mudah untuk mendeteksi apakah terdapat potensi mengalami diabetes yaitu dengan pengecekan kadar gula darah. Tujuan: Kegiatan ini bertujuan untuk melakukan screening DM melalui pemeriksaan kadar glukosa darah dan konsultasi hasil gula darah sewaktu di Rumah Pelayanan Sosial Pucang Gading, Semarang. Metode: Sasaran kegiatan ini adalah lansia yang berjumlah 50 orang. Waktu pelaksanaan yaitu pada Rabu, 31 Mei 2023. Kegiatan meliputi pemeriksaan cek gula darah sewaktu (GDS) dilanjutkan dengan konsultasi hasil gula darah. Hasil: Sebanyak 50 lansia yang ikut berpartisipasi dalam kegiatan ini sebagian besar adalah perempuan (62%), laki – laki (28%). Dari hasil pemeriksan GDS didapatkan rerata kadar GDS 152.12 gr/dl. Lansia yang tidak menderita DM (91%). Kesimpulan: Sebagian besar lansia memiliki kadar GDS yang normal. Namun, tetap perlu dilakukan upaya deteksi dini supaya tidak terjadi komplikasi Diabetes Mellitus.
Kata kunci: diabetes mellitus, gula darah sewaktu, lansia
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Background: Diabetes Mellitus (DM) is a non-communicable disease characterized by abnormal blood sugar levels. An easy way to detect whether there is potential for diabetes is to check blood sugar levels. Objective: This activity aims to screen for DM by checking blood glucose levels and consulting blood sugar results. Method: The target of this activity is the 50 elderly in the Rumah Pelayanan Sosial Pucang Gading, Semarang City. This activity was carried out on Wednesday, 31st of May, 2023. After implementation, random blood sugar examination then continued with consultation on blood sugar results. Result: A total of 50 elderly who participated in this activity were mostly women (62%), and men (28%). From the random blood sugar examination results, the average random blood sugar level was 152.12 gr/dl. Elderly who did not suffer from DM (91%). Conclusion: Most of the elderly have normal random blood sugar levels. However, early prevention is still needed to prevent complications of Diabetes Mellitus. 
Keywords: diabetes mellitus, elderly, random blood sugar level
The Coquí Call
Authors: Spooner T.M.
Published: November 2023

T. M. Spooner is the author of the novels The Salvation of La Purísima and Notes from Exile. Among others, his short fiction can be found in The Almagre Review and Flying Island Journal as the recipient of the 2022 Short Fiction prize. His essays have appeared in Studies in American Naturalism and Hispanic Journal. Spooner earned an M.A. in English Literature from Northern Arizona University.
Uncovering the Hydrocracking Efficiency of Iron-Based Catalysts: A Novel Approach to Asphaltene Transformation in Iranian Heavy Oil
Authors: Yılmaz Kadir , Gürdal Savaş , Yaşar Muzaffer
Published: November 2023

In the quest for optimal asphaltene conversion, this study investigated a range of cost-effective and easily accessible catalyst precursors, targeting both high yields of lighter products and minimal coke formation. The hydrocracking experiments were conducted within a 10 ml bomb-type reactor equipped with a reciprocating stirrer operating at a reciprocation rate of 200 times per minute. The experiments were performed at a temperature of 425°C for a duration of 90 minutes, with an initial hydrogen pressure of 100 bar. The outcomes of each experiment were assessed in terms of liquid products, coke production and C5- gas products. To analyze the Iranian heavy asphaltene, Nuclear Magnetic Resonance (1H NMR), Gel Permeation Chromatography (GPC) and elemental analysis were employed. Gas products were characterized using Gas Chromatography (GC). The investigation aimed to identify the catalyst precursor mixture that would maximize asphaltene conversion while minimizing coke production. A series of catalyst precursors, encompassing FeSO4·H2O, its binary mixtures with metal oxides (Fe2O3, Al2O3, CaO, SiO2), and combinations of Fe2O3, Al2O3, and SiO2 with elemental sulfur, were evaluated. The experimental results demonstrated that the toluene-soluble fraction (TSF), which includes the middle distillate portion, could be increased to a maximum of 56% while concurrently reducing the coke yield to 19%, down from the initial 36.9% when no precursor was used.
Strengthening personal data regulation in Russia: Economic implications and risks
Authors: Morosanova Anastasia
Published: November 2023

The enormous personal data breach of recent years is pushing regulators to tighten control over big data. The paper aims to analyse changes in big data regulation in Russia, and its possible effects on the competitive environment and economic performance of digital markets. New institutional economics theory, as well as some elements of law economics and industrial organization theory constitute the theoretical framework of the study. The research methods include comparison of structural alternatives and economic and statistical analysis. The empirical evidence covers 2021 data by Russia’s Federal State Statistics Service (Rosstat). The results of the study demonstrate that strengthening regulation of personal data (1) will widely affect all businesses involved in big data processing in all sectors of the economy, (2) will reduce innovation activity and investment attractiveness of digital markets in the short term, (3) will have a negative impact on small and medium-sized businesses. The statistical analysis indicates that there is room for applying an industry-wide approach, primarily ‘framework’ regulation, to big data markets. The research findings can be used by the regulator when developing or altering big data legal standards to prevent adverse economic implications.
On the coexistence of on-exchange and OTC segments in commodity markets
Authors: Ionkina Karina , Kurdin Aleksandr
Published: November 2023

The introduction of exchange trade in Russia is one of the ways to form a competitive commodity price that can act as a benchmark for the over-the-counter (OTC) segment. However, the exchange price may be subject to distortions, which may cause faults in antitrust law. Using the international commodity exchange experience, we aim to identify the risks of exchange trade arising amid the coexisting on-exchange and OTC segments. Methodologically, the paper relies on industrial organization theory and new institutional economics theory. In the research, the case study method was applied and data on the practices of commodity exchange introduced in different countries were used. As a result of the study, we have identified the risks of violating regulatory mechanisms in the market and of distorting effects on national markets, the risks in the areas of infrastructure restrictions and violations of antitrust laws, as well as the risks of price manipulation and distortion of exchange prices. We have proven that in the context of the coexistence of on-exchange and over-the-counter market segments, these risks can emerge even in cases of the successful development of global exchange trading.
“Acquire and leave”: Effects of startups acquisitions by digital ecosystems
Authors: Stavniychuk Anna , Markova Olga
Published: November 2023

Digital ecosystems penetrate many areas of modern life, they integrate many services and are growing partially through acquiring start-ups. These can lead to a rise of their market power, which in turn has caused the increased attention of antitrust regulators in recent years . The new changes into the Russian antitrust law contain the requirement for scrutiny for mergers above 7 billion of rubbles. This additional criterion is designed to include the acquisitions of startups by digital ecosystems that currently do not need to be announced to the Russian antitrust service. As for economic literature, there is no consensus on the way mergers with startups affect markets, in particular, venture capital market. The purpose of this work is to assess the effects of mergers of digital ecosystems with Russian startups in different niches of the venture investment in these niches. Methodologically, our study is based on economic theory and particularly on industrial organisation, antitrust economics; we also use econometrics while estimating causal inferences. We perform econometric analysis of panel data and matching to evaluate the effect of mergers of digital ecosystems with startups. In our quantitative analysis we use data collected from the website Rusbase, which gathers information on deals with Russian startups building primarily on open sources. In our study, we conclude that niches where digital ecosystems more actively purchase or invest in startups tend to be lower investments, smaller total and average purchase prices, which may indicate some washing out of investments in such niches. However, the effect we see may be present due to the changing popularity of niches and/or bringing forward of investor decisions, and not to the kill zone that is claimed to be one of the downsides of such mergers, since we observe a short-term increase in the number of investment decisions in a niche during the period when a startup is acquired by the digital ecosystem.
PENGEMBANGAN POTENSI WISATA GENTAN MELALUI PENULISAN SEJARAH LOKAL
Authors: Yuliati Umi , Irsyaf Fatahillah , Maulana Fajar , Dian Intan , Agve Isabel , Putri Jovina , Amalia Khoirroh , Putri Kinanti , Marccelita Lorient , Adinda Rizka , Nur Zakiyatun
Published: November 2023

Desa Gentan menjadi desa wisata yang dikenal dengan nama Gentan Geopark Village. Pesona wisata yang dimiliki Desa Gentan meliputi potensi alam, budaya, sejarah, dan kuliner menjadi daya tarik tersendiri bagi wisatawan. Gentan Geopark Village mulai dikembangkan pada tahun 2019 dengan mengangkat konsep desa wisata alam yang berasal dari warisan alam yang terbentuk jutaan tahun lalu. Dalam satu tujuan desa wisata Gentan Geopark Village terdapat lima destinasi wisata yang secara langsung dapat dikunjungi, yaitu Platar Ombo, Gunung Sepikul Segendong, Wisata Batu Seribu, Sendang Lele, dan Embung Pacinan. Desa Gentan juga memiliki warisan budaya berupa cerita rakyat berbentuk mitos dan legenda yang perlu dikembangkan untuk meningkatkan minat wisatawan.Pengabdian ini bertujuan untuk mengenalkan geowisata di Desa Gentan yang di dalamnya memuat cerita rakyat yang belum banyak orang ketahui untuk menambah wawasan budaya dan sejarah. Aspek folklore ini dapat dijadikan ajang promosi wisata dengan menceritakan kisah-kisah menarik terdahulu. Metode yang digunakan dalam pengabdian ini berupa observasi, diskusi, dan wawancara. Diawali dengan melakukan observasi untuk melihat kondisi sekitar destinasi wisata di Desa Gentan dilanjutkan diskusi bersama perangkat desa dan beberapa warga sekitar untuk membahas masalah apa yang sedang terjadi di destinasi wisata Desa Gentan dan solusinya.Metode terakhir adalah wawancara dengan sesepuh desa untuk menggali cerita rakyat yang berkembang di kawasan geowisata Desa Gentan yang akan dituangkan ke dalam video profil wisata Desa Gentan dan Buku Saku Gentan Geopark Village. Selain itu, kegiatan pengabdian juga berupa pengoptimalisasian akun instagram dari Gentan Geopark Village agar Desa Gentan mampu memanfaatkan media masa untuk menarik wisatawan.
PENINGKATAN SISTEM PENGELOLAAN KEUANGAN DAN PEMASARAN DIGITAL PADA UMKM CHALODO SIBALI RESOE
Authors: Supri Zikra , Sahrir Sahrir , Hamid Rahmad Solling , Sultan Sultan , Riyanti Riyanti
Published: November 2023

Transformasi digital menjadi salah satu faktor utama dalam pengembangan dan keberlanjutan Usaha Mikro, Kecil Menengah (UMKM). Salah satu bentuk dukungan pemerintah berkaitan dengan upaya digitalisasi UMKM, hanya saja upaya ini masih belum sepenuhnya di lakukan oleh UMKM dengan alasan masih memiliki kendala dalam implementasinya. Mitra dalam pengabdian ini adalah UMKM Chalodo Sibali Resoe yang memproduksi hasil olahan coklat. Urgensi dari pelaksanaan pengabdian ini terkait penyelesaian permasalahan yang dihadapi mitra. Tujuan kegiatan pengabdian secara umum yaitu untuk memberikan solusi kepada mitra terkait permasalahan yang dihadapi dalam bentuk program maupun luaran yang nanti dapat di manfaatkan oleh masyarakat/mitra. Metode penyelesaian permasalahan dalam pengabdian ini yaitu dimulai dengan melakukan Focus Group Discussion (FGD) selanjutnya pembuatan sistem akuntansi sederhana dan pelatihan/sosialisasi terkait perpajakan dan digital marketing. Pengabdian dilakukan berdasarkan kegiatan yang direncanakan diawal antara lain melakukan Focus Group Discussion (FGD) dengan Mitra. FGD ini membahas tentang kebutuhan mitra terkait sistem keuangan yang dibutuhkan serta beberapa hal terkait dokumen perpajakan didiskusikan untuk memudahkan dalam pelatihan nantinya. Selanjutnya menyusun dan membuat sistem keuangan sederhana yang disesuaikan dengan usaha mitra. Dalam hal ini pembuatan sistem dengan memperhatikan jenis usaha yang miliki dalam hal ini menggunakan siklus usaha manufaktur/produksi. Pelaksanaan Sosialisasi dan Pelatihan teknis Perpajakan serta pemasaran digital. Kegiatan pengabdian ini mitra dapat meningkatkan pengetahuan tentang perpajakan dan pemasaran digital, serta tersedianya laporan keuangan sederhana untuk mitra.
SOSIALISASI PENGHITUNGAN UNIT COST DAN POLA TARIF RUMAH SAKIT UMUM DAERAH TELUK KUANTAN KABUPATEN KUANTAN SINGINGI
Authors: Iznillah Muhammad Luthfi , Azlina Nur , Darlis Edfan , A Al azhar , Nasir Azwir , Ningsih Rahmita Budiarti , Nurulita Suci , Maulida Yusni
Published: November 2023

Layanan kesehatan merupakan layanan publik yang merupakan ujung tombak pembangunan kesehatan masyarakat. Rumah sakit sebagai penyelenggara layanan kesehatan dituntut untuk dapat memberikan pelayanan prima namun disisi lain tarif yang dikenakan juga harus dapat dijangkau oleh masyarkat.  Problematika biaya layanan menjadi hal yang sangat krusial sehingga mendorong seluruh elemen yang berkepentingan untuk menghitung secara riil biaya pelayanan yang dikeluarkan oleh rumah sakit. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk melakukan sosialisasi Penghitungan Unit Cost dan Pola Tarif pada Rumah Sakit Umum Daerah Teluk Kuantan Kabupaten Kuantan Singingi. Metode pelaksanaan kegiatan ini dengan memberikan ceramah dan penjelasan terkait analisis biaya satuan (Unit Cost) dan pola tarif layanan kesehatan Rumah sakit, yang dalam pelaksanaannya dilakukan bersama stakeholders yang terkait selama 1 hari pada tanggal 12 juni 2023. Hasil yang didapatkan adalah terlaksananya kegiatan sosialissi penghitungan unit cost dan pola tarif di RSUD Teluk Kuantan, yang Dengan adanya kegiatan tersebut Rumah Sakit mampu mengindentifikasi jenis layanan, karakter produk layanan, dan biaya. Kegiatan ini juga menjadi bahan acuran dan referensi dalam evaluasi tarif yang berlaku dan juga sebagai dasar penyusunan tarif baru berdasarkan perhitungan unit cost, kegiatan ini juga menjadi dasar bagi rumah sakit untuk menilai capain kinerja dan dasar penyusunan anggaran rumah sakit, serta sebagai pola dalam menyusun strategi keuangan. Dengan adanya kegiatan ini maka diharapkan rumah sakit dapat melakukan penyesuaian tarif baru, sehingga dapat mencapai kinerja yang akan berdampak kepada peningkatan kualitas pelayanan rumah sakit.
Organização Social e Projetos de Geração de Trabalho e Renda – Leituras de um Estudo de Viabilidade Social em Comunidades Tradicionais de Pesca no Litoral Norte Fluminense.
Authors: Timóteo Geraldo Márcio , Silva Rafael Moraes da , Ritter Karina , ramos mirian de freitas da silva
Published: November 2023

Este trabalho é uma pesquisa financiada Pelo Projeto de Educação Ambiental (PEA) Pescarte. Uma medida mitigatória exigida pelo Ibama dentro do Licenciamento Ambiental Federal. O objetivo do presente t
UMA REFLEXÃO LINGUÍSTICA DA REALIDADE DE SOCIOEDUCANDOS DE GOIÁS: TRANSCENDENDO LIMITES DE UMA TEORIA MESTIÇA/NÔMADE
Authors: Ferreira Vanderson Gonçalves , Oliveira Hélvio Frank de , Morais Carla Mariana Silva De
Published: November 2023

Resumo: Este artigo descreve resultados parciais de uma pesquisa em andamento, com os internos da Unidade Socioeducativa de Internação de Porangatu, acompanhados por uma professora do curso de Letras
MPB como Música Parcialmente Brasileira: o colonialismo cultural interno na perspectiva de artistas paraenses da cena translocal contemporânea
Authors: Moreira Nélio Ribeiro
Published: November 2023

Neste artigo, entrelaçando a perspectiva histórica à antropológica, procuro apresentar o ponto de vista de artistas paraenses radicados na centralidade da cultura musical do país – o Eixo Rio-São Paulo, onde se constituiu uma cena translocal no mundo da canção paraense -, sobre o colonialismo interno contemporâneo na cultura musical brasileira. O objetivo é demonstrar como as leituras dos atores paraenses que estão inseridos nesse processo de objetificação do diferenciante para controle, o que é efetivado pelo grupo sonoro do campo musical brasileiro na contemporaneidade, são manifestações da arregimentação de discursos e narrativas como recursos dotados de uma postura crítica e de carga simbólica em processos de interação pelo conflito.
Os caminhos da Serra Grande e o Parque Estadual do Ibitipoca
Authors: Arruda Danielle Aparecida
Published: November 2023

Neste trabalho analisaremos a política de criação de Unidades de Conservação tendo como foco as relações e dinâmicas entre sociedade e natureza, a exclusão das comunidades que vivem em seu entorno dos processos de implementação, gestão e da própria concepção de uma área de conservação. Os caminhos e trilhas que ligavam as comunidades ao Parque Estadual do Ibitipoca serão usados como exemplo do rompimento de vivências tradicionais. Entendemos que este fato impacta nas relações de sociabilidade entre as populações que ocupavam esse território comunitariamente. Buscamos demonstrar como os silenciamentos das memórias e tradições dessas populações prosseguem até os dias atuais, desconsiderando os saberes e fazeres ligados ao lugar, as relações, identidades e pertencimentos das comunidades que foram afetadas com a estatização do território.
Espiritualidad y saber ancestral: “La partería tradicional afro"
Authors: Armas Diónys Cecilia Rivas , Mercerón Ismenia de Lourdes
Published: November 2023

La práctica de la partería tradicional afro, es una experiencia heredada del África, legado ancestral que perdura, es un hacer comunitario muy especial, que forma parte de la espiritualidad en las comunidades afrodescendientes, que se aprende mediante la tradición oral, todo el ritual se hereda desde que son niñas, mirando y acompañando a sus madres o abuelas, quienes son las parteras mayores. En Venezuela la partería está presente en muchas zonas rurales, comunidades indígenas y afrovenezolanas, donde se congregan los conocimientos heredados de nuestros pueblos originarios y africanos. En cuanto a la partería afro tradicional, en el enclave afrodescendiente de Chuao en el estado Aragua, sus pobladores dan testimonio de su existencia como una manifestación cultural viva que forma parte de las tradiciones, saberes populares y experiencias vividas de las mujeres y las madres espirituales del pueblo. En el presente trabajo conoceremos los testimonios y experiencias de seis mujeres afrovenezolanas que desde la interpretación subjetiva del sentir de mujeres afro y la “geografía emocional”, nos permitieron develar una pluralidad de saberes en torno a la espiritualidad de la partería tradicional afro.
Indígenas puri LGBTQIA+: trajetórias de (re)existência
Authors: Muniz André da Silva , Vasconcelos Bruna Mendes de
Published: November 2023

O processo de invasão do continente hoje chamado de América envolveu um violento genocídio e etnocídio de populações nativas que levou diversos povos a serem declarados extintos, entre eles o povo Puri. Porém, com os avanços dos direitos indígenas nacional e internacionalmente, a população puri tem disputado politicamente para provar sua (re)existência histórica e, atualmente, demanda pelo reconhecimento de seus direitos. Situar seus corpos e garantir direitos à sua existência tem sido um enfrentamento político ainda mais árduo aos puris LGBTQIA+, considerando que vivemos em uma sociedade colonial-patriarcal que subalterniza indígenas, e corpos dissidentes das normativas sexuais e de gênero. Essas violências possuem uma origem comum, em um processo colonial que impôs normativas culturais aos corpos, suas práticas sexuais e matrimoniais, em detrimento às culturas indígenas que habitavam esse território. Neste trabalho, através de uma pesquisa autoetnográfica, refletimos sobre as continuidades desse processo colonial a partir da vivência puri LGBTQIA+ na contemporaneidade. Diante de um cenário onde os estudos de gênero e sexualidade têm poucos encontros com os estudos indígenas, esse trabalho visa compreender faces dessa opressão histórica contra esse grupo que intersecciona diversos marcadores sociais da diferença e, sobretudo, visibilizar suas estratégias de (re)existência.
Perspectivas decoloniais sobre o Monumento ao Garimpeiro em Boa Vista-RR
Authors: Triani Angélica Pereira , Ferreira Júnior Amarildo , Rodrigues Francilene dos Santos
Published: November 2023

Por muitos anos a história foi contada pela perspectiva dos vencedores. Um dos instrumentos utilizados para essa narrativa são os monumentos, que geralmente visam homenagear um povo, um feito histórico, uma divindade ou qualquer outro elemento que seja importante na história local. Esses elementos se encontram, na maioria das vezes, inseridos no meio urbano. A proposta deste trabalho é entender como essa inserção pode gerar narrativas dentro da cidade e como ela se relaciona com o espaço. Pretende-se analisar, também, a necessidade de novos e outros olhares para monumentos através de debates decoloniais. Essa construção se dá no âmbito de Boa Vista, capital do estado de Roraima, que foi marcado pela atividade garimpeira e pela exploração dos povos indígenas. Por esse motivo, a análise gira em torno do Monumento ao Garimpeiro, localizado no núcleo urbano da capital. A metodologia empregada parte de uma abordagem etno-histórica, que dialoga com referências bibliográficas principais acerca do tema. O objetivo foi levantar questionamentos e percepções críticas sobre a simbologia desse monumento em Boa Vista e despertar a proposta de ressignificação sob outros olhares.
Breve análisis sobre el tabaquismo y uso de E-cigarrillos
Authors: Grunbaum Sergio , Eliana; KRAUER, , Francisco; CANTERO, , Eduardo MINELLA, , Marcel LISBÔA, , Fabiana NOVAES,
Published: November 2023

Estudos sobre os malefícios causados ??pela fumaça produzida pelos conhecidos, comercializados e utilizados cigarros eletrônicos, ou e-cigarros, e-cig, I-pod, vapes entre tantos outros nomes que, embora denotem algumas diferenças estruturais, sobretudo de ordem física muito mais do que química, visto que todos os estudos apontam para uma mecanismo muito comum no organismo humano proveniente de todos esses dispositivos recarregável. Esses estudos são relativamente recentes, uma vez que os cigarros eletrônicos Foram colocados à venda na China, em 2003, e apenas nos Estados Unidos da América em 2006, mas trazem conclusões contundentes sobre o novo mal amplamente disseminado e isso é respirado por tantos, embora estas conclusões sejam incompletas, ao mesmo tempo menos de um ponto de vista puramente científico, requer vários testes produzíveis e replicável até à suposta fadiga, cuja evidência protege sobretudo o universo da bioquímica molecular, as reações de inúmeras ordens que culminam nos problemas macroscópicos de saúde já descritos na extensa literatura acadêmica. Este estudo objetivo traz todas aquelas informações que posteriormente foram catalogadas pelo vários cientistas ao redor do mundo para a nossa vida diária, clara e comum, e também procuraremos correlacionar as informações com os fatos e ações da nossa comunidade perto de incentivar o debate de questões que envolvem tantas áreas importantes do conhecimento médico entre médicos, professores, estudantes e funcionários de nossa instituição, fumantes, não fumantes, ex-fumantes, fumantes tabaco passivo, essências contendo nicotina, alcatrão e outras substâncias nocivas para nossas células. Existem muitos estudos realizados por especialistas que demandam materiais, lugares, condições e também voluntários, o que transforma a pesquisa científica em um funil dos quais apenas uma pequena parcela consegue obter dados significativos. Tanto que o A grande maioria, senão todos, dos artigos aqui citados trazem suas afirmações de possíveis falhas. e/ou erros cometidos ao longo dos experimentos. Nossos resultados serão mostrados mais tarde e será baseado nas realizações científicas dos pesquisadores nomeados cujos créditos se encontram nas referências bibliográficas.
Trastornos hepáticos, biliares y pancreáticos en la embarazada
Authors: LIN; BOGADO, FATIMA YOW CHIN , DA; SILVA, DOUGLAS CRUZ , SILVA; TEIXEIRA, DANIELE OLIVEIRA DA , DIAS Inaê Tatiana
Published: November 2023

Durante a gravidez ocorrem muitas transformações no corpo da mulher, que ocorrem devido ao aumento gradativo da progesterona, ocorrem alterações estruturais como alteração da coluna, aumento dos seios e escurecimento da barriga. Para que a gestação de um novo ser ocorra de forma completa, todos os sistemas do corpo feminino são utilizados ao extremo, portanto, há a necessidade de produzir glicose para a mãe e seu filho. O peso que a mãe ganha ao longo dos meses sobrecarrega seus músculos e ossos, causando compressão dos órgãos abdominais, dando espaço para o desenvolvimento da criança que cresce rapidamente; Às vezes, ocorre o colapso de um desses sistemas, de forma isolada, em cascata. Em grande parte, esses distúrbios no organismo se devem ao fato de nem sempre as gestantes terem tratamento adequado, principalmente no Paraguai, a maioria das gestantes não tem as consultas necessárias e por isso seus diagnósticos também não são feitos .a tempo para que o referido tratamento possa ser realizado adequadamente desde o início. Quando o risco é menor, estes podem ou não influenciar o processo gravídico, causando ou não danos à criança. Todos esses processos neste momento da vida estão ligados aos seus hábitos: alimentação compatível com suas necessidades, predisposições genéticas, interferências em suas atividades diárias, que nas fases finais da gravidez precisam ser modificado, o texto a seguir demonstra as principais preocupações relacionadas à gravidez: fígado, vesícula biliar e pâncreas.