bluuebunny/crossref_metadata_2025 huggingface dataset:
Untersuchungen zur Festigkeit und Tragfähigkeit von Holz unter dem Einfluss chemisch‐aggressiver Medien
Authors: Rug Wolfgang , Lißner Angelika
Published: February 2011

Holz zeigt eine hohe Beständigkeit gegenüber den meisten Chemikalien in allen drei Aggregatzuständen. Aus diesem Grund wird es häufig für Baukonstruktionen von chemischen Fabriken oder Lagerhallen für chemische Stoffe eingesetzt. Der Beitrag befasst sich mit dem aktuellen Stand der Erfassung der Korrosion und ihres Einflusses auf die Festigkeit von Holz und Brettschichtholz. Es wird die Berücksichtigung derartiger Einflüsse durch einen Modifikationsbeiwert” “Aggressive Medien” bei der Bemessung von Holzbauteilen erläutert.

Studies on the strength and ultimate limit design of timber under the influence of chemically aggressive media. Timber has a high resistivity to chemically aggressive agents. This is one of the reasons why timber structures are frequently being used in the construction of storage halls for chemical materials or of industrial buildings with aggressive environment. In this paper the state of the art of corrosion in timber and the consideration the chemical action by using a modification factor in the limit state design is presented.
Traunbrücke Steyrermühl — Sprengungsüberwachung mit BRIMOS® Structural Health Monitoring
Authors: Veit‐Egerer Robert , Wenzel Helmut , Reischl Josef , Hintringer Hermann
Published: February 2011

Die Traunbrücke Steyrermühl ist Teil der A1 Westautobahn und wurde in den Jahren 1959 und 1960 errichtet. Die 18‐feldrige Stahlbetonbrücke besteht aus zwei Richtungstragwerken und weist eine Gesamtlänge von 240,45 m auf. Im Hinblick auf die Gewährleistung der Tragsicherheit und Funktionsfähigkeit der Brücke wurden während der Sprengung des Richtungstragwerks Salzburg im August 2010 das unmittelbar benachbarte, zunächst bestehen bleibende Richtungstragwerk Wien überwacht und die Auswirkungen der Sprengung bewertet, wobei besonderes Augenmerk auf die primäre Tragstruktur (Bogen) gelegt wurde.

Da am Tragwerk bereits im Jahr 2005 eine dynamische Referenzmessung mit BRIMOS® durchgeführt wurde, konnte die aktuelle Untersuchung (Messung 2010) dadurch entsprechend effizienter gestaltet werden. Mit Hilfe ausgewählter Einzelpunkte am Brückentragwerk (HOT SPOTS) konnten das maßgebliche Tragverhalten der Brücke und etwaige Veränderungen umfassend beschrieben und quantifiziert werden. Ein direkter Vergleich im Abstand von fünf Jahren zeigt den Verlauf der gemessenen Tragfähigkeit über die Zeit (Brückendeck unter dem Einfluss der Verkehrsbelastung bzw. der Sprengung).

Blast of the Westbound Bridge Structure and Evaluation of its Affection on the remaining Eastbound Bridge Structure with BRIMOS® Structural Health Monitoring. The bridge object is part of the A1 highway and was constructed in 1959. It is composed of 18‐spans (reinforced concrete) and has a total length of 240,45 m. While the bridge structure — related with the driving direction Salzburg — was removed (blown) in August 2010, the remaining structure (driving direction Vienna) was monitored in order to evaluate the impact of the blasting with regard to its structural safety and operability. The investigation was focused on the primary load‐bearing structure (arch).

Due to the fact that an initial dynamic measurement with BRIMOS® has been conducted already in 2005, the prevailing investigation (measurement 2010) could be configured more efficiently. Measurements at selected single bridge locations (HOT SPOTS) enabled a comprehensive documentation and quantification of the bridge’s decisive structural behaviour and possible changes respectively. A direct comparison after 5 years of structural service life shows the progression of the measured structural resistance over time (bridge deck under the influence of traffic load and the bridge blasting).
10 Jahre Belastungsfahrzeug BELFA
Authors: Gutermann Marc , Schröder Carsten
Published: February 2011

Experimente sind Teil unserer Ingenieurgeschichte. Sie dienen der Absicherung neuer Bauweisen und helfen, theoretische Ansätze zu verstehen. Seit vielen Jahren wird in Sonderfällen auch im Bauwesen “experimentiert”: Der Belastungsversuch am bestehenden Bauwerk deckt das Tragwerkspotenzial auf und dient als direkter Nachweis der Tragsicherheit. Vor 10 Jahren ging das Belastungsfahrzeug BELFA in Betrieb, um Straßenbrücken und andere Ingenieurbauwerken zu testen. Dieser Artikel blickt auf die Entstehung zurück, schildert Einsatzerfahrungen und wagt einen Blick in die Zukunft.

10 year anniversary of BELFA. Experiments are part of the history of engineering science. They were used to validate theoretical assumptions and to understand the load bearing behavior of new constructions. In‐situ‐load tests explore the actual load carrying capacity and they can be used to proof sufficient load carrying safety for modern utilization. 10 years ago the special vehicle BELFA has gone into service to test road bridges and other civil structures. This article deals with its development, describes essential operatng experiences and will risk a look into the future.
Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug–drug interactions
Authors: Choi Min‐Koo , Jin Qing‐Ri , Choi Yeong‐Lim , Ahn Sung‐Hoon , Bae Myung‐Ae , Song Im‐Sook
Published: February 2011

Ketoconazole and rifampin are the most widely used compounds examined in recent drug–drug interaction (DDI) studies, and they have multiple roles in modulating drug metabolizing enzymes and transporters. To determine the underlying mechanisms of DDI, this study was performed to investigate the inhibitory effects of ketoconazole and rifampin on the functions of OAT1 and OATP1B1, and to evaluate the potential of ketoconazole and rifampin for DDI with substrate drugs for these transporters in a clinical setting. Ketoconazole inhibited OATP1B1‐mediated transport activity, while rifampin inhibited OAT1 and OATP1B1. Inhibition by rifampin and ketoconazole of the uptake of olmesartan, a substrate for OAT1 and OATP1B1, was evaluated in oocytes overexpressing these transporters. The Ki values for rifampin on OAT1 and OATP1B1‐mediated olmesartan uptake were 62.2 and 4.42 µM, respectively, and the Ki value for ketoconazole on OATP1B1‐mediated olmesartan uptake was 66.1 µM. As measured plasma concentrations of rifampin and ketoconazole were 7.29 and 6.4–13.3 µM, respectively, the likelihood of an OATP1B1‐mediated drug–drug interaction between rifampin and olmesartan is thought to be possible, whereas OAT1 or OATP1B1‐mediated DDI between rifampin or ketoconazole and olmesartan appears unlikely in the clinical setting. Copyright © 2011 John Wiley & Sons, Ltd.
Methylation profiling of rectal cancer identifies novel markers of early-stage disease
Authors: Leong K J , Wei W , Tannahill L A , Caldwell G M , Jones C E , Morton D G , Matthews G M , Bach S P
Published: February 2011

Background

Radical surgery is the de facto treatment for early rectal cancer. Conservative surgery with transanal endoscopic microsurgery can achieve high rates of cure but the histopathological measures of outcome used to select local treatment lack precision. Biomarkers associated with disease progression, particularly mesorectal nodal metastasis, are urgently required. The aim was to compare patterns of gene-specific hypermethylation in radically excised rectal cancers with histopathological stage.

Methods

Locus-specific hypermethylation of 24 tumour suppressor genes was measured in 105 rectal specimens (51 radically excised adenocarcinomas, 35 tissues adjacent to tumour and 19 normal controls) using the methylation-specific multiplex ligation-dependent probe assay (MS-MLPA). Methylation values were correlated with histopathological indices of disease progression and validated using bisulphite pyrosequencing.

Results

Five sites (ESR1, CDH13, CHFR, APC and RARB) were significantly hypermethylated in cancer compared with adjacent tissue and normal controls (P < 0·050). Methylation at these sites was higher in Dukes' A than Dukes' ‘D’ cancers (P = 0·013). Methylation at two sites (GSTP1 and RARB) was individually associated with localized disease (N0 and M0 respectively; P = 0·006 and P = 0·008). Hypermethylation of at least two of APC, RARB, TIMP3, CASP8 and GSTP1 was associated with early (N0 M0) disease (N0, P = 0·002; M0, P = 0·044). Methylation levels detected by MS-MLPA and pyrosequencing were concordant.

Conclusion

Locus-specific hypermethylation was more prevalent in early- than late-stage disease. Hypermethylation of two or more of a panel of five tumour suppressor genes was associated with localized disease.
Cellular and molecular mechanisms of the Ganoderma applanatum extracts induces apoptosis on SGC‐7901 gastric cancer cells
Authors: Ma Jieqiong , Liu Chanmin , Chen Yongqiang , Jiang Jihong , Qin Zhihong
Published: February 2011

To investigate the inhibition effect of Ganoderma applanatum extract (GAEAE) on human gastric cancer cell lines and apoptosis mechanism, Alamar Blue assay was used to assess the inhibition and apoptosis‐inducing effect of the GAEAE on proliferation of SGC‐7901 cells, the DNA ladders of the apoptosis cells was done, the mRNA expression of p53, Bax, Bcl‐2 and JNK were analysed by reverse transcription‐polymerase chain reaction. The levels of the Cyt C and the p53, Bax/Bcl‐2, JNK proteins and the caspase‐3 activity in the SGC‐7901 cells were measured with ELISA kits. Our data showed that the GAEAE markedly inhibited the proliferation of SGC‐7901 cells in a dose‐dependent manner. The expression of Bcl‐2 protein was down‐regulated and Bax, c‐jun, p53 protein expressions were up‐regulated by the GAEAE treatment in SGC‐7901 cells. The activity of caspase‐3 was markedly increased and the Cty C was markedly released into cytoplasm from the mitochondria after GAEAE action. In conclusion, our results indicated that the GAEAE could enhance the sensitivity of SGC‐7901 cells to the c‐jun, p53, Bax and Bcl‐2 induced apoptosis and provided a promising approach to anti‐human gastric cancer therapy with Ganoderma applanatum. Copyright © 2011 John Wiley & Sons, Ltd.
Ghrelin inhibits AGEs‐induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways
Authors: Xiang Ying , Li Qiang , Li Menglan , Wang Wei , Cui Can , Zhang Jinchao
Published: February 2011

Endothelial dysfunction caused by cell apoptosis is thought to be a major cause of diabetic vascular complications. Advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic vascular complications by inducing apoptosis of endothelial cells. The aim of this study was to explore the effect of ghrelin on AGEs‐induced apoptosis in cultured human umbilical vein endothelial cells (HUVECs) and the potential mechanisms involved in this process. Exposure to AGEs (200 mg l−1) for 48 h caused a significant increase in cell apoptosis, while pretreatment with ghrelin eliminated AGEs‐induced apoptosis in HUVECs, as evaluated by MTT assays, flow cytometry and Hoechst 33258 staining. The induction of caspase‐3 activation was also prevented by ghrelin in cells incubated with AGEs. Exposure to ghrelin (10−6 M) resulted in a rapid activation of extracellular signal‐regulated protein kinase (ERK)1/2 and Akt. The inhibitory effect of ghrelin on caspase‐3 activity was attenuated by inhibitors of ERK1/2 (PD98059), PI3K/Akt (LY294002) and growth hormone secretagogue receptor (GHSR)‐1a (D‐Lys3‐growth hormone releasing peptide‐6). The results of this study indicated that ghrelin could inhibit AGEs‐mediated cell apoptosis via the ERK1/2 and PI3K/Akt pathways and GHSR‐1a was also involved in the protective action of ghrelin in HUVECs. As such, ghrelin demonstrates significant potential for preventing diabetic cardiovascular complications. Copyright © 2011 John Wiley & Sons, Ltd.
Neuroprotector effect of p,p'‐methoxyl‐diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism
Authors: Pinton Simone , da Rocha Juliana Trevisan , Gai Bibiana Mozzaquatro , Prigol Marina , da Rosa Luiz Vinícius , Nogueira Cristina Wayne
Published: February 2011

The present study investigated whether the antioxidant activity of p,p'‐methoxyl‐diphenyl diselenide [(MeOPhSe)2] is involved in its protective effect against cognitive impairment induced by streptozotocin (STZ) in a model of sporadic dementia of Alzheimer's type (SDAT). Swiss mice were treated with STZ or vehicle [2 µl of 2·5 mg ml−1 solution; intracerebroventricularly (i.c.v.)] twice, 48 h apart. (MeOPhSe)2 (25 mg kg−1) or vehicle was orally administered 30 min prior to each STZ treatment. Neuroprotector effect of (MeOPhSe)2 on the behavioral performance of mice on spatial recognition memory consolidation was investigated in the Y‐maze test. After that, mouse brains were removed for measuring antioxidant parameters. (MeOPhSe)2 protected against the impairment in learning and memory caused by i.c.v. administration of STZ in mice. (MeOPhSe)2 protected against the increase in reactive species and the reduction of glutathione levels, as well as, the increase in superoxide dismutase and glutathione S‐transferase activities caused by STZ in whole brain. These results suggest that antioxidant property is involved, at least in part, in the neuroprotective effect of (MeOPhSe)2 on SDAT induced by STZ in mice. Copyright © 2011 John Wiley & Sons, Ltd.
The 8‐oxoguanine DNA N‐glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease
Authors: Tanrıkulu Sevda , Doğru‐Abbasoğlu Semra , Özderya Ayşenur , Ademoğlu Evin , Karadağ Berrin , Erbil Yeşim , Uysal Müjdat
Published: February 2011

Oxidative DNA damage, caused by either endogenous or exogenous sources of reactive oxygen species (ROS), has been linked several diseases including Graves' disease (GD). 7,8‐Dihydro‐8‐oxoguanine (8‐oxoG) is a major lesion produced by ROS and is considered a key biomarker of oxidative DNA damage. In humans, 8‐oxoG is mainly repaired by 8‐oxoguanine DNA N‐glycosylase‐1 (hOGG1), which is an essential component of the base excision repair (BER) pathway. The functional studies showed that hOGG1 Ser326Cys polymorphism is associated with the reduced DNA repair activity and increased risk for some oxidative stress‐related diseases. In this study, we firstly investigated hOGG1 Ser326Cys polymorphism in GD. According to our results, Cys/Cys genotype frequency in the GD patients (23.4%) was significantly higher than the controls (9.2%). Cys/Cys genotype had an 3.5‐fold [95% CI (confidence interval): 2.10–6.01, p < 0.001] the Cys allele had 1.83‐fold (95% CI: 1.43–2.34, p < 0.001) increase in the risk for developing GD. Our results suggest that Ser326Cys polymorphism of the hOGG1 gene is associated with GD risk. Copyright © 2011 John Wiley & Sons, Ltd.
The importance of oxidative stress in patients with chronic renal failure whose hypertension is treated with peritoneal dialysis
Authors: Demirci Şerafettin , Şekeroğlu Mehmet Ramazan , Noyan Tevfik , Köçeroğlu Ruşen , Soyoral Yasemin Usul , Dülger Haluk , Erkoç Reha
Published: February 2011

Increased oxidative stress is a well‐known phenomenon in dialysis patients. However, the contribution of hypertension to the oxidative stress in peritoneal dialysis patients has not yet been assessed. The present study aimed to investigate if hypertension had an additional effect on oxidative stress in peritoneal dialysis patients. A total of 50 patients treated with peritoneal dialysis were divided into two groups: The patients with mean of last three blood pressure results as 135/90 mmHg and above were considered hypertensive, the patients with lower blood pressure were considered normotensive. The control group included 25 healthy individuals. Serum malondialdehyde (MDA), advanced oxidation protein product (AOPP), myeloperoxidase (MPO), catalase (CAT) and glutathione peroxidase (GSH‐Px) levels were measured in all groups. MDA level, an indicator of lipid peroxidation, was significantly higher in the hypertensive group compared to the control group, while the increase in the normotensive group was not significant. However, the difference between the hypertensive and normotensive groups was significant. The levels of AOPP, an indicator of protein oxidation level, and MPO, an indicator of neutrophil activation, were not different between the groups, while the activities of antioxidant CAT and GSH‐Px decreased in both normotensive and hypertensive groups compared to the control group, and there was no significant difference between the patient groups. This study shows that both normotensive and hypertensive peritoneal dialysis patients have increased‐oxidative stress and decreased antioxidant levels and hypertension might have an additional effect on oxidative stress by increasing MDA level in peritoneal dialysis patients. Copyright © 2011 John Wiley & Sons, Ltd.
Handbook of Epigenetics: The New Molecular and Medical Genetics. Edited by Trygve Tollefsbol.
Authors: Jeltsch Albert
Published: February 2011

Academic Press, San Diego 2011, XIII+624 pp., hardcover $ 150.00.—ISBN 978‐0‐12‐375709‐8
Microwave‐Assisted Chemoselective Hydrogenation Reactions Incorporating Hydrogen as Reducing Agent
Authors: Schmöger C. , Gallert T. , Stolle A. , Ondruschka B. , Bonrath W.
Published: February 2011

The use of modern microwave equipment affords an easy and safe handling in the laboratory routine. The described quartz reactor system was tested in different reaction types to show its versatile applications. Various liquid‐phase hydrogenations were carried out successfully. The construction of the reactor allows the direct introduction of gases into the reaction mixture so that the reduction can be performed with gaseous hydrogen.
Biomass Size Reduction Machines for Enhancing Biogas Production
Authors: Kratky L. , Jirout T.
Published: February 2011

Biofuel technology seems to be a promising method for economically and environmentally prospective treatments of lignocellulosic wastes from various branches like food processing, forestry, or agriculture. Factors like the lignin content, crystallinity of cellulose, and particle size, limit the digestibility of hemicellulose and cellulose present in lignocelluloses. Biomass size reduction is a mechanical treatment process which due to increasing of the accessible surface area and decreasing of cellulose crystallinity improves the digestibility and the conversion of saccharides during hydrolysis. Informations about equipment design parameters and energy requirements are reviewed in relation to initial and final particle sizes, bulk density, and moisture content in biomass.
Artificial Neural Network for Modeling the Extraction of Aromatic Hydrocarbons from Lube Oil Cuts
Authors: Mehrkesh A. H. , Hajimirzaee S. , Hatamipour M. S. , Tavakoli T.
Published: February 2011

An artificial neural network (ANN) approach was used to obtain a simulation model to predict the rotating disc contactor (RDC) performance during the extraction of aromatic hydrocarbons from lube oil cuts, to produce a lubricating base oil using furfural as solvent. The field data used for training the ANN model was obtained from a lubricating oil production company. The input parameters of the ANN model were the volumetric flow rates of feed and solvent, the temperatures of feed and solvent, and the disc rotation rate. The output parameters were the volumetric flow rate of the raffinate phase and the extraction yield. In this study, a feed‐forward multi‐layer perceptron neural network was successfully used to demonstrate the complex relationship between the mentioned input and output parameters.
Gas‐Liquid Hydrodynamics and Mass Transfer in Aqueous Alcohol Solutions in a Split‐Cylinder Airlift Reactor
Authors: Moraveji M. K. , Sajjadi B. , Davarnejad R.
Published: February 2011

The influences of aliphatic alcohols (CnH2n+1OH, n = 1–4) and their concentrations (0–1 vol.‐%) on gas holdup, liquid circulation velocity, mixing time, and overall volumetric gas‐liquid oxygen mass transfer coefficient were considered in a split‐cylinder airlift reactor sparged with air. The carbon chain length of the alcohols and their concentration affect the airlift reactor performance. Alcohols reduced the average bubble sizes and increased the gas holdup, the interfacial area for mass transfer, and the gas‐liquid mass transfer coefficient. Since butanol has the most carbon atoms in its chain, it had the most significant effect on gas holdup and mass transfer enhancement. It also decreased the liquid circulation velocity by surface tension reduction. Two correlations based on dimensionless groups were applied to investigate the effect of hydrodynamics and molecules on gas holdup and mass transfer. A satisfactory agreement between correlation and experimental results was observed.
3D Analysis of Heat Transfer Intensification by Re‐Entrance Flow Pin‐Fins Microstructures with a Highly Thermal‐Conductive Plate
Authors: Wang Q. , Hessel V. , Rebrov E. V. , Werner B.
Published: February 2011

Joule heat‐induced hot‐spot formation sets severe limits in the operation of continuous annular electrochromatography (CAEC), a new concept for preparative separation as an analog to analytical capillary electrochromatography (CEC). This may lead to eluent flow perturbance, even to boiling, which would massively weaken separation efficiency and may even hamper the stationary phase used for separation. For reasons of system integration and high‐efficiency heat transfer, micro flow heat exchangers are considered with a separate coolant flow. A 3D numerical analysis of the heat transfer of water single‐phase laminar flow in a square microchannel and different arrays of micro pin‐fins was carried out using COMSOL Multiphysics. Several advanced materials with low electric conductivity and at the same time with high heat conductivity were put forward to be used in the CAEC system. As essential design point, it is proposed to constitute the micro heat exchanger from two different parts of the CAEC system, namely a microstructured pin‐fins plate and a so‐called conductive plate.
Plant Extraction with Aqueous Two‐Phase Systems
Authors: Schneider P. , Bischoff F. , Müller U. , Bart H.‐J. , Schlitter K. , Jordan V.
Published: February 2011

The extraction of phytochemicals from plants and their downstream processing is often associated with solvents, which are problematical with respect to health, safety, and environment. An alternative approach is the extraction with aqueous two‐phase systems, which offers a benign environment for complex molecular structures. Particularly nonionic surfactants like, e.g., Genapol® X‐080 and Tween® 65 in high concentrations in water can be used to form aqueous two‐phase systems. Sage (Salvia triloba) is used as a model plant, since it contains a relatively high concentration of the two triterpenes oleanolic acid (OA) and ursolic acid (UA), which are interesting due to their wide range of biological effects. Kinetic experiments have shown that an extractive isolation of triterpene acids using such mesophase systems is possible.
Effect of Microchannel Geometry on High‐Pressure Dispersion and Emulsification
Authors: Gothsch T. , Finke J. H. , Beinert S. , Lesche C. , Schur J. , Büttgenbach S. , Müller‐Goymann C. , Kwade A.
Published: February 2011

Experimental investigations of the effect of microchannel geometry on high‐pressure dispersion and emulsification were carried out. Customized microchannels of varying geometric principles were fabricated in silicon and steel. In order to characterize the process efficiency of microchannel geometries, the effects of the process parameters (mean velocity, Reynolds number, and local pressure drop) were examined and correlated to the dispersion and emulsification results. It is demonstrated that high pressure losses focused at a small channel length and high velocity gradients lead to high stress intensities and, in consequence, to low particle or droplet sizes. Thus, 2D orifices were successfully further improved regarding their process efficiency by adding a third‐dimension constriction.
On the Stabilization of Gold Nanoparticles over Silica‐Based Magnetic Supports Modified with Organosilanes
Authors: Oliveira Rafael L. , Zanchet Daniela , Kiyohara Pedro K. , Rossi Liane M.
Published: February 2011

The immobilization of gold nanoparticles (Au NPs) on silica is made possible by the functionalization of the silica surfaces with organosilanes. Au NPs could only be stabilized and firmly attached to silica‐support surfaces that were previously modified with amino groups. Au NPs could not be stabilized on bare silica surfaces and most of the NPs were then found in the solution. The metal–support interactions before and after the Au NP formation, observed by X‐ray absorption fine structure spectroscopy (XAFS), indicate a stronger interaction of gold(III) ions with amino‐modified silica surfaces than with the silanol groups in bare silica. An amino‐modified, silica‐based, magnetic support was used to prepare an active Au NP catalyst for the chemoselective oxidation of alcohols, a reaction of great interest for the fine chemical industry.
The Inorganic Perspective of Nerve Growth Factor: Interactions of Cu2+ and Zn2+ with the N‐Terminus Fragment of Nerve Growth Factor Encompassing the Recognition Domain of the TrkA Receptor
Authors: Travaglia Alessio , Arena Giuseppe , Fattorusso Roberto , Isernia Carla , La Mendola Diego , Malgieri Gaetano , Nicoletti Vincenzo G. , Rizzarelli Enrico
Published: February 2011

There is a significant overlap between brain areas with Zn2+ and Cu2+ pathological dys‐homeostasis and those in which the nerve growth factor (NGF) performs its biological role. The protein NGF is necessary for the development and maintenance of the sympathetic and sensory nervous systems. Its flexible N‐terminal region has been shown to be a critical domain for TrkA receptor binding and activation. Computational analyses show that Zn2+ and Cu2+ form pentacoordinate complexes involving both the His4 and His8 residues of the N‐terminal domain of one monomeric unit and the His84 and Asp105 residues of the other monomeric unit of the NGF active dimer. To date, neither experimental data on the coordination features have been reported, nor has one of the hypotheses according to which Zn2+ and Cu2+ may have different binding environments or the Ser1 α‐amino group could be involved in coordination been supported. The peptide fragment, encompassing the 1–14 sequence of the human NGF amino‐terminal domain (NGF(1‐14)), blocked at the C terminus, was synthesised and its Cu2+ and Zn2+ complexes characterized by means of potentiometric and spectroscopic (UV/Vis, CD, NMR, and EPR) techniques. The N‐terminus‐acetylated form of NGF(1‐14) was also investigated to evaluate the involvement of the Ser1 α‐amino group in metal‐ion coordination. Our results demonstrate that the amino group is the first anchoring site for Cu2+ and is involved in Zn2+ coordination at physiological pH. Finally, a synergic proliferative activity of both NGF(1‐14) and the whole protein on SHSY5Y neuroblastoma cell line was found after treatment in the presence of Cu2+. This effect was not observed after treatment with the N‐acetylated peptide fragment, demonstrating a functional involvement of the N‐terminal amino group in metal binding and peptide activity.
Chromium and Molybdenum Pentacarbonyl Complexes of Phosphinocarbodithioates: Synthesis, Molecular Structure and Behaviour in RAFT Polymerisation
Authors: Geagea Roland , Ladeira Sonia , Mazières Stéphane , Destarac Mathias
Published: February 2011

Molybdenum and chromium pentacarbonyldiphenylphosphinocarbodithioate complexes have been prepared in a one‐pot reaction from the corresponding metallocarbonyldiphenylphosphine. The complexes have been characterised by IR, 1H, 31P and 13C NMR spectroscopies and by mass spectrometry. The solid‐state structures of [Cr(CO)5{PPh2CS2CH(Ph)CH3}] (1) and [Mo(CO)5{PPh2CS2CH(Ph)CH3}] (2) are reported. Compounds 1 and 2 are isostructural and crystallise in the triclinic P space group. These new organometallic compounds are highly efficient reversible chain‐transfer agents for reversible addition–fragmentation chain‐transfer (RAFT) polymerisation of styrene (St) and n‐butyl acrylate (nBA), with controlled number‐average molar mass values and narrow dispersities (<1.2). The controlled character of the polymerisation was further exemplified by the synthesis of St and nBA diblock copolymers.
Rational Synthesis of Supramolecular Assemblies Based on Tetraplatinum Units: Synthesis, Characterization, and Selective Substitution Reactions of Four Different Pt4 Clusters
Authors: Tanaka Shinji , Yagyu Akihiro , Kikugawa Masashi , Ohashi Masato , Yamagata Tsuneaki , Mashima Kazushi
Published: February 2011

Four different types of square‐planar Pt4 clusters, trans‐[Pt4(μ‐OCOCH3)6(μ‐ArNCHNAr)2] (2: ArNCHNAr=N,N′‐diarylformamidinate), [Pt4(μ‐OCOCH3)7(μ‐ArNCHNAr)] (8), cis‐[Pt4(μ‐OCOCH3)6(κ4‐N4‐DArBp)] (9: DArBp=1,3‐bis(arylbenzamidinate)propane), and [Pt4Cl2(μ‐OCOCH3)5(κ4‐N2,P2‐dpfam)] (13: dpfam=N,N′‐bis[(2‐diphenylphosphino)phenyl]formamidinate), were successfully prepared by using selective substitution reactions of in‐plane acetate ligands of [Pt4(μ‐OCOCH3)8] (1), which has four in‐plane and four out‐plane acetate ligands, with appropriate capping ligands. Fundamental substitution reactions of the remaining in‐plane acetates with benzoic acid derivatives were also investigated. All newly prepared complexes were characterized from spectral and physical data and combustion analysis. X‐ray crystallographic studies of some of the clusters were also performed. Electrochemical measurements of amidinate‐modified Pt4 clusters revealed stepwise oxidation processes of the Pt4 core due to Pt49+/Pt48+ and Pt410+/Pt49+. Based on the lability of the in‐plane acetate ligands of the modified Pt4 clusters, reactions of cis‐[Pt4(μ‐OCOCH3)6(κ4‐N4‐DArBp)] (9 c: Ar=C6H4tBu‐4) with ferrocenedicarboxylic acid and p‐phenylenedipropionic acid resulted in the selective formation of cyclic dimers 17 and 18 and the reaction of 13 with 4,4′‐biphenyldicarboxylic acid afforded a linear dimer 20. The dimers were characterized by spectral data, as well as X‐ray analyses for 17 and 18. The finding of two Fe3+/Fe2+ redox couples in the electrochemical measurement of dimer 17 indicated that two ferrocenyl units in dimer 17 communicated electronically.
Complete Stereocontrol in Organocatalytic Additions of β‐Ketosulfoxides to Conjugated Aldehydes
Authors: García Ruano José Luis , Alvarado Cuauhtémoc , Díaz‐Tendero Sergio , Alemán José
Published: February 2011

The use of β‐ketosulfoxides as nucleophiles in reactions with α,β‐unsaturated aldehydes catalyzed by proline derivatives allows complete control of configuration at the two chiral centers that are created during 1,4‐addition reactions. The sulfinyl group can be used to create additional chiral centers in the resulting compounds and then removed while preserving the chirality of the carbon joined to the sulfur. The catalyst and the sulfinyl group are mainly responsible for the configurational control of the carbon atoms acting as electrophile and nucleophile, respectively, which allows the preparation of the four possible diastereoisomers in optically pure form. Theoretical calculations of the possible chiral nucleophilic species bearing diastereotopic faces allow us to postulate, for the first time, that enolates, instead of enols, are the active reagents in these reactions.
New Highly Stable Metallabenzenes via Nucleophilic Aromatic Substitution Reaction
Authors: Lin Ran , Zhang Hong , Li Shunhua , Wang Jiani , Xia Haiping
Published: February 2011

Treatment of the ruthenabenzene [Ru{CHC(PPh3)CHC(PPh3)CH}Cl2(PPh3)2]Cl (1) with excess 8‐hydroxyquinoline in the presence of CH3COONa under air atmosphere produced the SNAr product [(C9H6NO)Ru{CHC(PPh3)CHC(PPh3)C}(C9H6NO)(PPh3)]Cl2 (3). Ruthenabenzene 3 could be stable in the solution of weak alkali or weak acid. However, reaction of 3 with NaOH afforded a 7:1 mixture of ruthenabenzenes [(C9H6NO)Ru{CHC(PPh3)CHCHC}(C9H6NO)(PPh3)]Cl (4) and [(C9H6NO)Ru{CHCHCHC(PPh3)C}(C9H6NO)(PPh3)]Cl (5), presumably involving a PC bond cleavage of the metallacycle. Complex 3 was also reactive to HCl, which results in a transformation of 3 to ruthenabenzene [Ru{CHC(PPh3)CHC(PPh3)C}Cl2(C9H6NO)(PPh3)]Cl (6) in high yield. Thermal stability tests showed that ruthenabenzenes 4, 5, and 6 have remarkable thermal stability both in solid state and in solution under air atmosphere. Ruthenabenzenes 4 and 5 were found to be fluorescent in common solvents and have spectral behaviors comparable to those organic multicyclic compounds containing large π‐extended systems.
Enantiopure, Monodisperse Alleno‐acetylenic Cyclooligomers: Effect of Symmetry and Conformational Flexibility on the Chiroptical Properties of Carbon‐Rich Compounds
Authors: Rivera‐Fuentes Pablo , Nieto‐Ortega Belén , Schweizer W. Bernd , López Navarrete Juan T. , Casado Juan , Diederich François
Published: February 2011

A series of enantiopure, monodisperse alleno‐acetylenic cyclooligomers were synthesized. The single‐crystal X‐ray structures of the cyclic trimer and hexamer were resolved, providing insights into the symmetry of these molecules. Electronic circular dichroism (ECD), optical rotatory dispersion (ORD), Raman spectroscopy, and vibrational circular dichroism (VCD) data were analyzed with the aid of theoretical calculations. This multidimensional approach ultimately provided general guidelines that are useful for designing carbon‐rich compounds with intense chiroptical properties.
ChemInform Abstract: Crystal Structures of New Alkali Metal‐Rich Oxometallates: Rubidium Aluminate Tetrahydroxide, Rb9(AlO4)(OH)4, Rubidium Orthogallate, Rb5GaO4, Cesium bis‐Chromate(IV) Oxide, Cs10(CrO4)2O, and Cesium Diindate, Cs8In2O7.
Authors: Bender Johannes , Wohlfarth Andreas , Hoch Constantin
Published: February 2011

The crystal structures of several new alkali metal oxometallates are determined by single crystal XRD.
ChemInform Abstract: Crystal Structure and Magnetic Properties of Ce7Ni5.+‐.xGe3 .+‐.xIn6 and Pr7Ni5.+‐.xGe3 .+‐.xIn6.
Authors: Chumalo Nataliya , Nychyporuk Galyna P. , Pavlyuk Volodymyr V. , Poettgen Rainer , Kaczorowski Dariusz , Zaremba Vasyl' I.
Published: February 2011

Ce7Ni4.73Ge3.27In6 and Pr7Ni4.96Ge3.04In6 are prepared by arc‐melting of the elements and characterized by single crystal XRD and magnetic measurements.
ChemInform Abstract: Structural Relationships Between New Carbide La14Sn(MnC6)3 and Fully Ordered La11(MnC6)3.
Authors: Zaikina Julia V. , Zhou Haidong , Latturner Susan E.
Published: February 2011

Crystals of the title compounds are prepared from the elements using a La/Ni eutectic flux (950 °C, 3 h) and their structures are determined by single crystal XRD.
ChemInform Abstract: 3D [Ag—Mg] Polyanionic Frameworks in the La4Ag10Mg3 and La4Ag10.3Mg12 New Ternary Compounds.
Authors: Solokha Pavlo , De Negri Serena , Pavlyuk Volodymyr , Eck Bernhard , Dronskowski Richard , Saccone Adriana
Published: February 2011

The new title compounds are obtained from melts of the elements and characterized by single crystal XRD and TB‐LMTO‐ASA electronic structure calculations.
ChemInform Abstract: LiCo1‐yByO2 as Cathode Materials for Rechargeable Lithium Batteries.
Authors: Julien C. M. , Mauger A. , Groult H. , Zhang X. , Gendron F.
Published: February 2011

Title compounds with 0.05 ≤ y ≤ 0.35 are synthesized from mixtures of LiOH, LiBO2, and Co3O4 (flowing O2; 1.
ChemInform Abstract: Zero‐ and One‐Dimensional Thioindates Synthesized under Solvothermal Conditions Yielding α‐In2S3, β‐In2S3 or MgIn2S4 as Thermal Decomposition Products.
Authors: Quiroga‐Gonzalez E. , Kienle L. , Naether C. , Chakravadhanula V. S. K. , Luehmann H. , Bensch W.
Published: February 2011

The structures of (II) and (IV) are determined by single crystal XRD.
ChemInform Abstract: Novel Microporous Zirconium Silicate (K2ZrSi3O9·2H2O) from High Temperature Phase Transformation.
Authors: Ferreira Artur , Lin Zhi , Soares Maria R. , Rocha Joao
Published: February 2011

The title compound is synthesized from an aqueous solution of KOH, SiO2, and ZrCl4 (autoclave, 230 °C, 18 h) followed by calcination in air at 910—920 °C for 15—30 h.
ChemInform Abstract: Hydrothermal Syntheses and Crystal Structures of Two New Mixed‐Valence Vanadium Oxides [Ni(en)2(H2O)2] [Ni(en)3]2 [V16O38Cl]·3(H2O) and (H3O)2V3O8.
Authors: Liu Xing , Yin Xian‐Hong , Zhang Feng
Published: February 2011

The synthesis of (IV) and (V) demonstrates that the reactant stoichiometry of the system plays a key role in the formation of different structures.
ChemInform Abstract: Synthesis, Crystal Structure, Spectrum Properties, and Electronic Structure of a Novel Non‐Centrosymmetric Borate, BiCd3(AlO)3(BO3)4.
Authors: Chen Xuean , Yin Hui , Chang Xinan , Zang Hegui , Xiao Weiqiang
Published: February 2011

The new title compound is synthesized by solid state reaction of Bi2O3, CdO, Al(OH)3, and B2O3 in a molar ratio of 1:2:2:2 (Au crucible, 600 °C, 4 weeks).
ChemInform Abstract: Direct Hydrothermal Synthesis and Physical Properties of Rare‐Earth and Yttrium Orthochromite Perovskites.
Authors: Sardar Kripasindhu , Lees Martin R. , Kashtiban Reza J. , Sloan Jeremy , Walton Richard I.
Published: February 2011

The lanthanoid chromites LnCrO3 (Ln: Y, La, Pr, Sm, Gd, Dy, Ho, Yb, Lu) are prepared by hydrothermal treatment (autoclave, 320—380 °C, 48 h) of an amorphous mixed‐metal hydroxide precursor precipitated from aqueous KOH solutions of LnCl3 or Ln(NO3)3 and Cr(NO3)3 (70 °C, 2—3 d).
ChemInform Abstract: Preparation and Structural Study from Neutron Diffraction Data of Pr5Mo3O16.
Authors: Martinez‐Lope M. J. , Alonso J. A. , Sheptyakov D. , Pomjakushin V.
Published: February 2011

The title compound is synthesized by solid state reaction of Pr6O11 and MoO2 (air, 1100 °C, 12 h).
ChemInform Abstract: A Series of New Supramolecular Structures Constructed from Triethylenediamine and Different Polyoxometalates.
Authors: Cui Xiao‐Bing , et al. et al.
Published: February 2011

Compounds (IV), (VI), and (VIII) are characterized by powder XRD, XPS, and IR spectroscopy.
ChemInform Abstract: Structure, Bonding, and Magnetic Response in Two Complex Borides: Zr2Fe1‐δRu5+ δB2 and Zr2Fe1‐δ (Ru1‐xRhx) 5+δB2.
Authors: Brgoch Jakoah , Yeninas Steven , Prozorov Ruslan , Miller Gordon J.
Published: February 2011

Zr2Fe0.87Ru5.13B2 and Zr2Fe0.82(Ru/Rh)5.18B2 are synthesized by arc melting of stoichiometric mixtures of the elements followed by annealing at 1000 °C (14 d).
ChemInform Abstract: Synthesis of Li2MgIr and LiMgIrH6: Guidance from DFT.
Authors: Salvador J. R. , Herbst J. F. , Meyer M. S.
Published: February 2011

Li2MgIr, whose existence is suggested by DFT calculations, is prepared from the elements using a 33% molar excess of Mg (sealed stainless steel tube, 510 °C, 4 d).
ChemInform Abstract: Ruthenium‐Catalyzed Addition of Carboxylic Acids or Cyclic 1,3‐Dicarbonyl Compounds to Propargyl Alcohols.
Authors: Berger Stefanie , Haak Edgar
Published: February 2011

The monomeric RCO is found to be a suitable catalyst for the title reactions.
ChemInform Abstract: Cyclopropenium‐Activated Beckmann Rearrangement. Catalysis versus Self‐Propagation in Reported Organocatalytic Beckmann Rearrangements.
Authors: Vanos Christine M. , Lambert Tristan H.
Published: February 2011

In situ generated gem‐dichlorocyclopropenes efficiently convert oximes to amides.
ChemInform Abstract: Binuclear Iron(III) Phthalocyanine(μ‐oxodimer)/Tetrabutylammonium Oxone: A Powerful Catalytic System for Oxidation of Hydrocarbons in Organic Solution.
Authors: Neu Heather M. , Zhdankin Viktor V. , Nemykin Victor N.
Published: February 2011

Aromatic hydrocarbons are efficiently oxidized to the corresponding quinones under mild conditions.
ChemInform Abstract: Amberlyst‐15 in Ionic Liquid: An Efficient and Recyclable Reagent for Nucleophilic Substitution of Alcohols and Hydroamination of Alkenes.
Authors: Qureshi Ziyauddin S. , Deshmukh Krishna M. , Tambade Pawan J. , Dhake Kishor P. , Bhanage Bhalchandra M.
Published: February 2011

Notable advantages offered by this metal‐free reaction system are the use of an ionic liquid as green solvent, higher yields, greater substrate compatibility, and simple work‐up procedures.
ChemInform Abstract: Thioglycoluril as a Highly Efficient, Recyclable and Novel Organocatalyst for N‐Boc Protection of Amines.
Authors: Khaksar Samad , Vahdat Seyed Mohammad , Tajbakhsh Mahmood , Jahani Fatemeh , Heydari Akbar
Published: February 2011

Chemoselective monoprotection of primary and secondary amines is achieved in a short reaction time, even in the presence of other functional groups.
ChemInform Abstract: Improved Synthesis of Phenylethylamine Derivatives by Negishi Cross‐Coupling Reactions.
Authors: Goddard Craig M. L. , Massah Ahmad Reza , Jackson Richard F. W.
Published: February 2011

N‐Trifluoroacetyl‐protected (β‐aminoalkyl)arenes are synthesized by conversion of the corresponding (aminoalkyl) iodides into organozinc iodides followed by the coupling reaction with aryl iodides.
ChemInform Abstract: Highly Active and Recyclable Silica Gel‐Supported Palladium Catalyst for Mild Cross‐Coupling Reactions of Unactivated Heteroaryl Chlorides.
Authors: Lee Dong‐Hwan , Jung Ji‐Young , Jin Myung‐Jong
Published: February 2011

A silica gel‐supported β‐ketoiminatophosphane‐Pd complex is shown to be a highly active and long‐living catalyst for Suzuki, Stille, and Sonogashira coupling reactions in aqueous medium.
ChemInform Abstract: Preparation of Stereodefined Homoallylic Amines from the Reductive Cross‐Coupling of Allylic Alcohols with Imines.
Authors: Chen Ming Z. , McLaughlin Martin , Takahashi Masayuki , Tarselli Michael A. , Yang Dexi , Umemura Shuhei , Micalizio Glenn C.
Published: February 2011

It is found that Ti‐mediated coupling of imines with allylic alkoxides generally allows stereodefined formation of diverse homoallylic amines.
ChemInform Abstract: Synthesis of Nonsymmetric Divinylarenes by a Heck—Wittig Reaction Combination.
Authors: Burmester Christian , Mataka Shuntaro , Thiemann Thies
Published: February 2011

A new one‐pot, two‐step protocol for the combined Wittig‐Heck reaction using aldehydes, e.g. (I) and (V), preformed ylides such as (III) and acrylates or styrenes leads predominantly to E‐configurated products.
ChemInform Abstract: Hoveyda—Grubbs′ Catalyst Confined in the Nanocages of SBA‐1: Enhanced Recyclability for Olefin Metathesis.
Authors: Yang Hengquan , Ma Zhancheng , Wang Yuekui , Wang Yunwei , Fang Li
Published: February 2011

Immobilization of the second generation Hoveyda—Grubbs′ catalyst on mesoporous silica SBA‐1 via a simple adsorption gives a highly recyclable solid catalyst for olefin methathesis reactions.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Chiral Allylic Esters.
Authors: Cannon Jeffrey S. , Kirsch Stefan F. , Overman Larry E.
Published: February 2011

A number of chiral allylic esters can be prepared in high yields and excellent enantioselectivity starting from imidates of type (I).
ChemInform Abstract: Rhodium‐Catalyzed Selective anti‐Markovnikov Addition of Carboxylic Acids to Alkynes.
Authors: Lumbroso Alexandre , Vautravers Nicolas R. , Breit Berhard
Published: February 2011

The Rhodium catalyst is developed for the intermolecular hydro‐oxycarbonylation of terminal alkynes leading to (Z)‐anti‐Markovnikov enol esters in good to high yields and excellent stereoselectivities.
ChemInform Abstract: Silica Phosphoric Acid: An Efficient and Recyclable Catalyst for the Solvent‐Free Synthesis of Acylals and Their Deprotection in MeOH.
Authors: Zhang Fuyi , Liu Hong , Zhang Qing‐Ju , Zhao Yu‐Fen , Yang Feng‐Ling
Published: February 2011

Silica phosphoric acid is shown to be an efficient and recyclable catalyst for the solvent‐free synthesis of acylals and their deprotection in MeOH.
ChemInform Abstract: Stereoselective 6π‐Electron Electrocyclic Ring Closures of 2‐Halo‐amidotrienes via a Remote 1,6‐Asymmetric Induction.
Authors: Hayashi Ryuji , Walton Mary C. , Hsung Richard P. , Schwab John H. , Yu Xueliang
Published: February 2011

The electrophilic halogenation of the allenamides proceeds (E)‐stereoselectively.
ChemInform Abstract: Method for Regio‐ and Stereoselective Synthesis of (E)‐β,γ‐Unsaturated Acids from Aldehydes under Solvent‐Free Conditions.
Authors: Zhang Shi‐Jie , Hu Wei‐Xiao
Published: February 2011

A modified Knoevenagel condensation reaction using NMM as a base is presented.
ChemInform Abstract: Asymmetric Inter‐ and Intramolecular Cyclopropanation Reactions Catalyzed by a Reusable Macroporous‐Polymer‐Supported Chiral Ruthenium(II)/Phenyloxazoline Complex.
Authors: Abu‐Elfotoh Abdel‐Moneim , Phomkeona Kesiny , Shibatomi Kazutaka , Iwasa Seiji
Published: February 2011

The novel heterogeneous Ru‐complex is highly efficient in the preparation of trans‐cyclopropanes such as (III) and (V), which are formed in most cases with excellent diastereoselectivity and enantioselectivity.
ChemInform Abstract: Nickel‐Catalyzed Cyclization of Difluoro‐Substituted 1,6‐Enynes with Organozinc Reagents Through the Stereoselective Activation of C—F Bonds: Synthesis of Bicyclo[3.2.0]heptene Derivatives.
Authors: Takachi Manabu , Kita Yusuke , Tobisu Mamoru , Fukumoto Yoshiya , Chatani Naoto
Published: February 2011

Investigations reveal that the presence of a fluorine substituent is required for a successful cyclization.
ChemInform Abstract: Highly Enantio‐, Regio‐ and Diastereo‐Selective One‐Pot [2 + 3]‐Cycloaddition Reaction via Isomerization of 3‐Butynoates to Allenoates.
Authors: Sampath Magesh , Loh Teck‐Peng
Published: February 2011

Compound (IVc) is contaminated with 35% of the corresponding allenoate.
ChemInform Abstract: Efficient, Rapid, and Regioselective Bromination of Phenols and Anilines with N‐Bromosaccharin Using Tungstophosphoric Acid as a Heterogeneous Recyclable Catalyst.
Authors: Alinezhad Heshmatollah , Tavakkoli Sahar Mohseni , Salehian Fatemeh
Published: February 2011

Phenols and anilines can be brominated regioselectively using N‐bromosaccharin as brominating agent in the presence of tungstophosphoric acid as a catalyst.
ChemInform Abstract: Highly Enantioselective Michael Addition of Nitroalkanes to Chalcones Using Chiral Squaramides as Hydrogen Bonding Organocatalysts.
Authors: Yang Wen , Du Da‐Ming
Published: February 2011

Catalysts (I) and (II) are developed to prepare both enantiomers which are of particular interest since they show very different biological activity.
ChemInform Abstract: Efficient Copper‐Catalyzed Direct Amination of Aryl Halides Using Aqueous Ammonia in Water.
Authors: Meng Fei , Zhu Xinhai , Li Ying , Xie Jianwei , Wang Bo , Yao Junhua , Wan Yiqian
Published: February 2011

The easy availability of the ligand, the commercially available cheap copper source, the use of a green solvent and aqueous ammonia as the readily available nitrogen source are features of this protocol.
ChemInform Abstract: Gold‐Catalyzed Rearrangement of Substituted Allyl Aryl Ethers.
Authors: Vyvyan James R. , Dimmitt Heidi E. , Griffith Jennifer K. , Stefens Laura D. , Swanson Rebecca A.
Published: February 2011

The Au(I)‐complexes catalyze the process to produce both formal [3,3] and [1,3] rearrangement products through an ionic mechanism.
ChemInform Abstract: Diastereoselective Synthesis of Homoallylic Alcohols with Adjacent Tertiary and Quaternary Centers by Using Functionalized Allylic Aluminum Reagents.
Authors: Peng Zhihua , Bluemke Tobias D. , Mayer Peter , Knochel Paul
Published: February 2011

It is demonstrated, that freshly generated allylic aluminum reagents react with aldehydes or ketones to give monoallyl alcohols.
ChemInform Abstract: A Chiral‐Anion Generator: Application to Catalytic Desilylative Kinetic Resolution of Silyl‐Protected Secondary Alcohols.
Authors: Yan Hailong , Jang Hyeong Bin , Lee Ji‐Woong , Kim Hong Ki , Lee Soon Won , Yang Jung Woon , Song Choong Eui
Published: February 2011

The resolution can be efficiently achieved with KF in the presence of a potassium complex of BPE, generated in situ.