bluuebunny/crossref_metadata_2025 huggingface dataset:
ПОВЕДІНКА ІНДЕКСІВ ФОНДУ ТА ЕКОНОМІЧНИХ ІНДИКАТОРІВ ЯК КРИЗОВІ ПРАПОРЦІ
Authors: Мажара Г. А. , Сазонова М. О.
Published: October 2023

Фінансова криза – ситуація, коли ціни на активи сильно падають, інвестори розпродають активи, очікуючи дефіциту ліквідності. Фінансові кризи включають вибух спекулятивної фінансової бульбашки, крах фондового ринку, суверенний дефолт або валютну кризу. Фінансові кризи можуть виникати з різних причин. Найбільш очевидною причиною є перевищення цін на активи або установи, які не підтримуються нічим, крім ринкового попиту. Якщо цю ситуацію доповнює очікувана людська поведінка, тривале невтручання уряду або просто «чорний лебідь», криза може спричинити рецесію чи депресію. Головна схожість усіх криз у тому, що вони повторюються. Ось мета цієї статті: поглянути на світові кризи попередніх десятиліть, вивчити їх причини, дослідити, як поводилися індекси світових фондових ринків. Що ще важливіше, ми зараз подивимося на індекси, проаналізуємо ситуацію в банківській системі, щоб мати можливість очікувати найближчої кризи. Стаття на тему «Поведінка індексів фонду та економічних індикаторів як кризові прапорці» написана з метою виявити першопричини основних глобальних криз ХХ-ХХІ століть та порівняти їх. Для вивчення економічної ситуації використовувались валовий світовий продукт і світові індекси: Wilshire 5000, The Global DOW index. Головна схожість усіх криз у тому, що вони повторюються. Тому актуальність теми полягає у тому що кризи це циклічне явище в економіці і розуміючи їх першопричини можна заздалегідь спрогнозувати кризу і підготуватися до неї. Методами дослідження були системний аналіз наукової літератури; порівняльний аналіз; систематизація, порівняння та узагальнення результатів. В результаті дослідження поглянули на глобальні кризи попередніх десятиліть, вивчити їх причини, дослідити, як поводилися індекси світових фондових ринків. Та після аналізу кількох криз з кількома індексами можна сказати, що для подальших досліджень доцільно використовувати індикатор The Global DOW index, як рівнозважений фондовий індекс. Практична цінність статті полягає у тому що тепер, знаючи поведінку низки індикаторів в минулому перед кризами, можна спрогнозувати майбутні кризи. В наступних дослідженнях необхідно побудувати комплексний аналіз показників для поточної ситуації, щоб спрогнозувати спади в економіці.
EKSISTENSI PONDOK PESANTREN UNIVERSITAS ISLAM INDONESIA DALAM PENERAPAN SISTEM PENDIDIKAN MULTIKULTURAL (STUDI KASUS)
Authors: Diinu Tsabitul Azmi  , Hilma Zurriyah Rabbaniyah  , Kurniawan Dwi Saputra
Published: October 2023

Kehidupan di pondok pesantren sudah tidak asing dengan adanya keberagaman dan perbedaan sehingga diperlukan suatu sistem Pendidikan Multikultural, yaitu pendidikan yang menghargai perbedaan agar tidak menjadi sumber konflik atau perpecahan. Dalam Pendidikan Multikultural, setiap peradaban dan kebudayaan berada dalam posisi yang sejajar dan sama. Salah satu tujuan penting dari sistem pendidikan multikultural adalah dalam membantu peserta didik agar memperoleh pengetahuan dan mampu menghargai orang lain yang berbeda, baik dalam suku, budaya serta latar belakang dan kepribadianya. Penerapan sistem Pendidikan multikultural di Pondok Pesantren Universitas Islam Indonesia di rancang khusus terhadap santri dengan maksud dan tujuan yang sama, para santri dibekali pengetahuan untuk saling mengenal dan menghargai perbedaan. Penelitian ini bertujuan untuk mengemukakan Eksistensi Pondok Pesantren Universitas Islam Indonesia dalam penerapan sistem Pendidikan Multikultural terhadap para santri. Metode penelitian ini adalah Deskriptif dengan menguraikan butir-butir penjelasan yang dilakukan pada saat mengumpulkan data. Adapun teknik pengumpulan data yang digunakan adalah wawancara. Hasil analisis sederhana dalam penerapan sistem Pendidikan Multikultural menujukan adanya keterkaitan dengan nilai-nilai pendidikan islam yang selaras dengan berbagai kegiatan yang ada di Pondok Pesantren Universitas Islam Indonesia.
IMPLEMENTASI SUSTAINABLE MARKETING ENTERPRISE (SME) DALAM MENGHADAPI PERSAINGAN PADA INDUSTRI PRODUK HERBAL PERSPEKTIF EKONOMI ISLAM (STUDI KASUS PADA CV. AGRADAYA INDONESIA)
Authors: Zizi Whais Al Qoornie  , Junaidi Safitri
Published: October 2023

Model Sustainable Marketing Enterprise (SME) perspektif ekonomi islam atau juga dikenal Sharia Sustainable Marketing Enterprise  memiliki peranan yang strategis dalam menjawab persaingan pasar. Salah satu unsur SME perspektif ekonomi islam terdapat syariah marketing value yang terdapat tiga prinsip yaitu 1) Brand (Merek), 2) Service (Pelayanan), 3) Proces (Proses). Ketiga prinsip tersebut mendorong untuk mengambil heart share dari target pasar perusahaan. Adapun tujuan penelitian ini untuk mengetahui implementasi Sustainable Marketing Enterprise (SME) dalam menghadapi persaingan pada industri produk herbal di CV. Agradaya Indonesia perspektif ekonomi islam. Penelitian ini menggunakan jenis penelitian kualitatif deskriptif dengan observasi langsung ke CV. Agradaya Indonesia dan wawancara langsung dengan founder dan Chief Executive Officer (CEO) sebagai informan penelitian. Hasil penelitian ini adalah CV. Agradaya Indonesia mengimplementasikan 1) Brand dengan metode fungsional benefit dan emosional benefit serta berkolaborasi. 2) Service dengan memberikan kecepatan, garansi, promosi, bundling, hadiah, edukasi dan membangun hubungan berkelanjutan 3) Process, bermitra dengan petani rempah ditanaman dengan metode agrofestari kemudian diproses oleh petani mitra dengan teknologi tepat guna rumah surya untuk penangan pasca panen yang kemudian distandarisasi akhir berbentuk bahan baku rempah kering dan kemudian dikemas oleh Agradaya sesuai regulasi BPOM dan HACCP
ANALISIS NILAI-NILAI KETAUHIDAN DALAM BUKU TUHAN ADA DI HATIMU KARYA HABIB HUSEIN JA’FAR AL-HADAR DAN RELEVANSINYA TERHADAP PENDIDIKAN AGAMA ISLAM
Authors: Dea Kurnia  , Wanti Nur Aprilian  , M Nurul Ikhsan Saleh
Published: October 2023

Tauhid menjadi tema yang sangat penting dalam pandangan Islam. Betapa pentingnya dasar pendidikan yang menjadi pondasi pada seseorang. Penelitian ini bertujuan untuk menganalisis nilai-nilai ketauhidan yang terkandung dalam sebuah buku Tuhan Ada di Hatimu dan bagaimana relevansinya terhadap pendidikan agama Islam yang diharapkan dapat menambah wawasan khasanah keilmuan. Tahapan penelitian dimulai dari penentuan objek analisis, pengumpulan data-data informasi, pengkajian klasifikasi secara deskriptif, dan penyimpulan mengenai nilai-nilai tauhid yang terkandung di dalam buku tersebut. Hasil penelitian ini menunjukan bahwa terdapat kandungan nilai-nilai ketauhidan, yakni: 1) Tauhid rububiyyah dengan meyakini Allah maha kuasa dengan kekuatan sejati adalah miliknya, 2) Tauhid uluhiyyah dengan meg-Esakan Allah dalam penghayatan aktivitas sehari-hari, 3) Tauhid asma dan sifat Allah seperti bashiran, ilmun, dan aliman. Nilai ketauhidan tersebut perlu ditanamkan kepada anak. Namun tidak hanya secara kognitif saja, melainkan afektif dan psikomotorik juga
Comparative Analysis of Integrated Filtering Method Using UWB Localization in Indoor Environments
Authors: Ranjan Rahul , Shin Donggyu , Jung Yoonsik , Kim Sanghyun , Yun Jong-Hwan , Kim Chang-Hyun , Lee Seung-jae , Kye Joongeup
Published: October 2023

This research paper investigates ultra-wideband (UWB) localization systems by focusing on the use of average filter (AVG), Kalman filter (KF), and extended Kalman filter (EKF) algorithms, as well as a novel integrated filtering method that incorporates low-pass filter (LPF) into AVG, KF, and EKF. The study aims to improve localization loss in indoor environments using a TurtleBot robot equipped with a camera to observe ground truth positions. To evaluate the effectiveness of the proposed algorithms, a comprehensive comparison of the raw and filtered data with the camera-based ground truth observations is performed. Quantitative analyses of the results, including max, min, max-min, and mean error, are performed to evaluate the localization performance of the algorithms and the integrated filtering method. The results reveal that the integrated filtering method has performed better accuracy in comparison with existing methods.
Eco-Friendly Synthesis of Zerovalent Iron Nanoparticles in Carbon Nanofibers for Wastewater Treatment
Authors: Iqbal Zafar , Ausanio Giovanni , Parlato Loredana , Pepe Giovanni Piero , Ali Shahid
Published: October 2023

The presence of heavy metals in industrial effluents has recently become a source of concern for human health and the environment. Efficient removal of metal ions and wastewater treatment is essential for protecting public health and the environment. In this study, we present an eco-friendly, green synthesis of reactive and fully dispersed zerovalent iron nanoparticles (nZVI) in carbon nanofibers via an electrospinning technique. In this novel study, green tea (GT) was used as environmentally friendly, polyvinyl alcohol (PVA) was used for the stabilization and reduction of nZVI, and tetraethyl orthosilicate (TEOS) was added to provide flexibility and to increase the specific surface area of the nZVI based nanofibers. GT contains polyphenols, which act as reducing agents, converting iron ions into nZVI and the particles can then serve as the building blocks for the carbon nanofibers. TEOS can also contribute to the stability of the nZVI by coating their surfaces with a silica layer. This silica layer helps prevent the oxidation of the nZVI, thereby reducing their catalytic activity. The nZVI-based composite (∼ 400 nm) / carbonized (∼ 200 nm) nanofibrous mats were fully characterized by scanning electron microscopy. The average size of the nZVI embedded in the composite and carbonized nanofibers can range from 50 nm to 100 nm. The x-ray diffraction (XRD) analysis of nZVI-based carbon nanofibers showed that there is no crystallinity and a single-phase cubic structure. Both energy-dispersive X-ray spectroscopy (EDX) and Fourier transform infrared (FTIR) analysis also confirmed the formation of single-phase nZVI-based composite / carbonized nanofibers. The high intensity of the peaks in the FTIR spectrum indicates the formation of nZVI in the nanofibers structure. The electrospun nZVI-based carbon nanofibers have a higher surface area and better reactivity due to small particle size and large surface area-to-volume ratio. They can provide excellent water stability and dispersibility in water compared to bulk nZVI, which tend to agglomerate and settle quickly. Additionally, nanofiber morphology can enhance the mechanical strength and durability of the composite material. Due to low-cost synthesis and their high efficiency in removing pollutants, these nanofibers could be used as nano-filters for wastewater treatment.
Autonomous Vehicle Decision Making with Policy Prediction for Handling a Round Intersection
Authors: Li Xinchen , Guvenc Levent , Aksun-Guvenc Bilin
Published: October 2023

Autonomous shuttles have been used as end mile solutions for smart mobility in smart cities. The urban driving conditions of smart cities with many other actors sharing the road and the presence of intersections have posed challenges to the use of autonomous shuttles. Round intersections are more challenging as it is more difficult to perceive the other vehicles in and near the intersection. Thus, this paper focuses on decision making of autonomous vehicles for handling round intersections. The round intersection is introduced first, followed by introductions of the Markov Decision Process (MDP), the Partially Observable Markov Decision Process (POMDP) and the Object Oriented Partially Observable Markov Decision Process (OOPOMDP) which are used for decision making with uncertain knowledge of the motion of the other vehicles. The Partially Observable Monte-Carlo Planning (POMCP) algorithm is used as the solution method and OOPOMDP is applied to decision making for autonomous vehicles in round intersections. Decision making is formulated first as a POMDP problem, and the penalty function is formulated and set accordingly. This is followed by improvement of decision making with policy prediction. Augmented objective state and policy-based state transition are introduced and simulations are used to demonstrate the effectiveness of the proposed method for collision free handling of round intersections by the ego vehicle.
Pengaruh Ekstrak Etanolik Daun Kelor (Moringa oleifera, Lam.) Terhadap Ekspresi NF-κβ Pankreas Tikus Wistar (Rattus norvegicus) Model Sindroma Metabolik Terinduksi
Authors: Naufal Naila Rahima , Budiani Dyah Ratna , Setyawan Novan Adi
Published: October 2023

Pendahuluan: Sindrom metabolik (SM) menyebabkan kerusakan pulau langerhans pankreas akibat aktivasi NF-κβ. Kandungan fitokimia dari ekstrak etanolik daun kelor mencegah kerusakan pulau langerhans pankreas. Penelitian ini bertujuan untuk mempelajari pengaruh peningkatan dosis ekstrak etanolik daun kelor terhadap ekspresi NF-κβ pankreas tikus wistar model SM terinduksi.
Metode: Penelitian ini bersifat eksperimental laboratorik. Subjek penelitian berjumlah 30 ekor tikus wistar dibagi menjadi 5 kelompok yaitu KI kelompok kontrol normal, KII kelompok kontrol positif, dan kelompok perlakuan SM dengan dosis ekstrak etanolik daun kelor 150mg/kgBB/hari pada KIII, 250mg/kgBB/hari pada KIV, dan 250mg/kgBB/hari pada KV. Model tikus SM diberikan diet tinggi lemak dan STZ-NA. Preparat IHC diamati dengan mikroskop cahaya dan image raster kemudian dihitung skor IDS. Analisis data menggunakan uji Kruskal Wallis dilanjutkan dengan uji post-hoc tes Mann-Whitney U (p<0,05).
Hasil: Rerata IDS tertinggi pada KII dan terendah pada KI. Hasil uji Kruskal Wallis menunjukan adanya pengaruh ekstrak etanolik daun kelor terhadap ekspresi NF-κβ (p=0,035). Uji post-hoc menunjukan hasil yang signifikan pada KII dengan KI (p=0,01) dan KIII (p=0,037). Tidak terdapat perbedaan yang signifkan antar kelompok perlakuan.
Kesimpulan: Ekstrak etanolik daun kelor dosis150 mg/kgBB/hari menurunkan ekspresi NF-κβ pankreas tikus wistar (Rattus norvegicus) model sindrom metabolik terinduksi, namun peningkatan dosis ekstrak etanolik daun kelor (Moringa oleifera, Lam.) tidak menurunkan ekspresi NF-κβ pankreas tikus wistar (Rattus norvegicus) model sindrom metabolik terinduksi.
Hubungan Pemberian ASI Eksklusif dan Susu Formula Terhadap pH Feses Bayi 0-6 Bulan
Authors: Aqillah Azzah  , Rokhayati Evi , Umma Husnia Auliyatul
Published: October 2023

Pendahuluan: ASI merupakan asupan bayi yang paling praktis, murah, sempurna, dan higienis karena diminum langsung dari payudara ibu. Bayi yang mengonsumsi ASI, memiliki pH feses yang lebih asam daripada normal yaitu 4,5–5,5. Hilangnya Bifidobacteria dalam jumlah besar pada usus bayi dapat mengakibatkan peningkatan pH feses menjadi lebih basa dan memicu terjadinya dysbiosis mikrobiota usus. Selain faktor pemberian ASI eksklusif atau susu formula, penelitian ini juga meneliti faktor-faktor lain yang dinilai memengaruhi pH feses bayi. Penelitian ini bertujuan untuk mengetahui hubungan pemberian ASI eksklusif dan susu formula terhadap pH feses bayi 0–6 bulan.
Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional. Pengambilan sampel dilakukan di Posyandu-posyandu dibawah kerja Puskesmas Ngoresan yang memenuhi kriteria peneltian sebanyak 50 sampel. Teknik sampling yang digunakan adalah simple random sampling. Data yang diperoleh akan dianalisis menggunakan uji Chi-square.
Hasil: Dari hasil analisis bivariat dengan uji Chi-square didapatkan hasil bahwa usia ibu (p=0.018) dan konsumsi ASI eksklusif atau susu formula (p=0.000) memiliki hubungan yang signifikan terhadap pH feses bayi.
Kesimpulan: Terdapat hubungan yang signifikan antara konsumsi ASI eksklusif atau susu formula terhadap pH feses bayi 0-6 bulan.
Pelatihan Senam Kaki Buerger Allen di Puskemas Purwodiningratan
Authors: Febrinasari Ratih Puspita , Prabowo Nurhasan Agung , Putri Desy Puspa , Setyawan Sigit
Published: October 2023

Pendahuluan: Prevalensi Diabetes Mellitus (DM) tipe 2 di Indonesia semakin meningkat. Penyakit ini berkaitan dengan timbulnya komplikasi dan hal ini akan menurunkan kualitas hidup pasien. Penurunan komplikasi dilakukan pengobatan farmakologis dan non farmakologis. Salah satu upaya terapi non farmakologis adalah dengan edukasi dan Latihan fisik seperti senam kaki diabetes. Tujuan dari pengabdian ini adalah memberikan edukasi mengenai DM tipe 2 dan pelatian senam kaki Buerger Allen pada penderita DM tipe 2 di puskesmas Purwodiningratan.

Metode: Langkah pengabdian yang akan dilakukan meliputi pengumpulan bahan dan materi, perencanaan, dan kegiatan inti.  Setelah kegiatan akan dilakukan pelaporan dan evaluasi

Hasil dan pembahasan: Penyuluhan dan edukasi sebagai acara inti akan dilakukan pada tanggal 27 Mei 2023 dengan materi: mengenal DM tipe 2 dan gejalanya, mengenal obat-obatan DM tipe 2, olahraga dan aktifitas fisik pada DM tipe 2, komplikasi pada DM tipe 2. Pasien diberikan instruksi senam kaki dan diajarkan oleh para instruktur senam kaki. Selain itu pasien mendapatkan leaflet dan video senam kaki diabetes dengan metode Buerger allen agar dipraktekkan di rumah dan mendapatkan hasil optimal.

Kesimpulan: Pengabdian sudah terlaksana dengan baik, masyarakan penderita DM tipe 2 yang menjalani pelatihan mendapatkan penurunan gejala komplikasi DM tipe 2.
DEVELOPMENT OF A SIMPLE QUESTIONNAIRE FOR EARLY DETECTION OF PREMORBID FUNCTIONAL HEALTH IMPAIRMENTS
Authors:   Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Moscow, MARTYUSHEV-POKLAD ANDREY V. , YANKEVICH DMITRY S. ,   Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Moscow, SAVITSKAYA NATALIYA G. ,   Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Moscow, GRECHKO ANDREY V. ,   Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Moscow
Published: October 2023

Introduction. Health systems and health status in developed economies demonstrate failure of chronic disease prevention, in part due to too late health interventions postponed until the patient has a medical diagnosis. Healthcare system can benefit from P4 medicine, which needs special questionnaires to collect person-centered data. The available questionnaires do not match the practical tasks of the P4-medicine paradigm. Aim. The aim is to develop a simple questionnaire for mass early screening of health status in the adults within the P4-medicine paradigm. Material and Methods. We transformed and adapted the Suboptimal health status questionnaire (SHSQ-25) to meet the requirements of mass screening in the P4 medicine paradigm. Information value, sensitivity and specificity of the new questionnaire were tested in several focus groups of respondents through matching with detailed clinical interview aimed at prevention of chronic health conditions. Results and discussion. The Functional impairment questionnaire “FIQ-15” includes 15 questions covering the most common warning symptoms seen in respondents of various health states. Two alternative scales, 5-point and 3-point, are proposed to rate the symptoms. Based on the rate of functional impairments, their impact on everyday functioning, and the need in detailed examination and/or help, respondents are divided into 4 risk groups. More than 400 respondents filled the FIQ-15 over 2 years, 300 of them underwent detailed clinical interviews for questionnaire development and validation. The system of data acquisition and interpretation based on FIQ-15 allows automated mass screening for early functional impairments, fast primary sorting into risk groups (‘traffic light’ system), semi-quantify the severity of functional impairments and their impact on life quality, propose effective routing of patients to further examination and diagnosing, and involve the respondent in active management of one’s health. Conclusion. The proposed FIQ-15 questionnaire can become a simple, affordable and informative tool in early mass screening for functional impairments in the P4-medicine paradigm, in sorting the respondents based on their need in detailed examination, and in real life decision support, including the respondent’s participatory decisions regarding one’s health management.
PANCREATITIS IN HIV-INFECTED PATIENTS. CAUSES AND TRENDS. ANALYSIS OF A CASE SERIES
Authors:   Moscow Research and Clinical Center for TB Control, GAFAROV UMEDZHON O. , PLOTKIN DMITRIY V. ,   Moscow Research and Clinical Center for TB Control, RESHETNIKOV MIKHAIL N. ,   Moscow Research and Clinical Center for TB Control, ROMANOVA ELENA Y. ,   Moscow Research and Clinical Center for TB Control, BARSKIY BORIS G. ,   Moscow Research and Clinical Center for TB Control, MOKHOV DMITRIY A. ,   Rozanov Moscow Regional Hospital, STERLIKOV SERGEY A. ,   Moscow Research and Clinical Center for TB Control, BOGORODSKAYA ELENA M. ,   Moscow Research and Clinical Center for TB Control
Published: October 2023

Introduction. Acute pancreatitis is common in HIV-infected patients and has a number of significant features that directly affect the methods of diagnosis and treatment. Aim. To study risk factors of acute pancreatitis development in patients with HIV-infection with immunosuppressive disorders and to determine treatment and diagnostic algorithm in this group of patients. Material and Methods. Anamnestic data, results of diagnosis and treatment of two groups of patients with acute pancreatitis were analyzed. The first group included 79 patients with acute pancreatitis combined with HIV infection who were admitted to the clinic for the period from 2017 to 2021. The second group consisted of 558 HIV-negative patients with acute pancreatitis. Results and discussion. In the group of HIV-positive patients it turned out that alimentary factors caused pancreatitis in 31,7% of patients, biliary concretions and hypertension in 16,5% of patients, it was not possible to establish an initiating factor of the disease in 16,5% of cases. In people living with HIV drugs and infectious agents caused acute pancreatitis in 11,4% and 24,1% of cases respectively. Alimentary factors were in the lead in the group of HIV–negative patients (52,2%), gallstone disease was considered as the second main cause of pancreatitis – 36,0% of cases, viral infections and the consequences of the use of drugs respectively accounted for 1,6%, and in 10,2% of patients the cause of acute pancreatitis remained unknown. Discussion. As our study showed, in patients with normal immune status the drug etiology of pancreatitis prevailed in the structure of the causes of pancreatitis, in patients with immunodeficiency, respectively, infectious causes of pancreatitis were dominant. Based on the obtained data on the cause of pancreatitis, the rational therapeutic and diagnostic algorithm was formed, the use of which in clinical practice will allow timely initiation of etiotropic and pathogenetic therapy in a group of HIV- positive patients. Conclusion. The etiological structure of HIV-associated acute pancreatitis directly depends on the patient’s immune status and differs in many ways from that of HIV-negative patients or patients receiving antiretroviral therapy. The severity of the disease and the risk of death remain high in acute pancreatitis caused by infectious agents against the background of immunosuppression.
IMPROVING ENERGY PARAMETERS OF OIL JET PUMPS
Authors: Rogovyi Andrii , Kostiuk Mariia , Azarov Andrii
Published: October 2023

The difficulty of extracting oil from great depths due to the huge amounts of sand, water and other impurities has led to the fact that well jet oil pumps are becoming more common. Their use in oil production is facilitated by such factors as practical insensitivity to the content of gas and other impurities dissolved in oil compared to other types of pumps; simplicity of design and the absence of moving parts, which is inherent in all jet technology. The reliability and durability of jet pumps are an order of magnitude higher than those of any other pumps used in oil and gas production. Obtaining excellent characteristics of a jet oil pump requires a systematic approach to the analysis of characteristics and modeling of the pump flow. Pumping oil is a complex task because there is a fairly large variety of oil and substances that can be included in it in various fields. This leads to problems when modeling pump operation and using more complex fluid flow models from rheological models to modeling cavitation. The complication of mathematical models of the flow provokes an increase in modeling errors, complications of flow verification and finding rational coefficients and corrections to turbulence models. In the paper, the energy parameters of oil jet pumps are improved by calculation. A jet pump for pumping oil has been designed and numerical calculations have been carried out with different models of turbulence and aggregate states of media. The kinematic characteristics of the flow are obtained and the efficiency of the pump is calculated. As a result of the calculation of the model with cavitation, it was obtained that the pump efficiency is 10 %, which is 3 times higher than the calculation result without cavitation. The increased efficiency is consistent with asymptotic methods for calculating pump characteristics.
ADVANTAGES OF USING HYDRAULIC EQUIPMENT OF MODULAR MOUNTING IN THE MODERNIZATION OF MACHINE HYDROSYSTEMS
Authors: Fatieieva Nadiia , Fatyeyev Oleksandr , Ponomarov Vladyslav
Published: October 2023

With each passing year, automation schemes that use hydraulics are becoming more and more complex. With the large number of hydraulic devices in the scheme, replacing threaded connections with other methods of mounting becomes very important. The analysis of building and mounting of hydraulic drives and hydraulic units on the example of metal-cutting machines, namely: round saw and turret lathe. The analysis shows that the optimal variant of pipeless mounting of hydraulic drives is mounting with the use of modular and butt hydraulic equipment. The main advantages of modular mounting are: reducing the number of pipelines and their connections; increasing drive rigidity, reducing noise; compactness, small size and weight; reducing labor costs and time for design and manufacture of the drive; convenience of operation, the ability to quickly reconfigure the drive, replace the failed unit without disassembly of the hydraulic drive; unification of mounting plates and hydraulic panels; increasing their seriality. In addition, with this type of mounting, there is always a constant distance between the individual devices and regulating bodies of different apparatuses that make up a typical element of a hydraulic system (its structural contour). This makes it possible to determine in advance the characteristics, properties and "behavior" not of individual hydraulic apparatuses included in the hydraulic system of the machine drive, but of groups of apparatuses that make up typical modular units. We have an opportunity to judge the characteristics of the hydraulic drive of the machine as a whole already at the stage of its design by predetermined characteristics of typical elements (modular units) included in the hydraulic system of the machine, which will significantly reduce the time for designing, debugging and launching the drive in production. The group of metalworking equipment, in which the hydraulic drive on the basis of modular and butt hydraulic equipment is easily performed, includes: turning group machines; drilling and boring machines; grinding group machines; broaching machines; cutting machines, milling machines and other special machines. Justified selection of the nomenclature of normalized hydrostations, modular and butt hydraulic apparatuses and other unified elements can solve the problem of creating up to 70–75 % of the manufactured hydraulic drives completely based on unified units.
CENTRIFUGAL PUMP DESIGN USING AXSTREAM® SOFTWARE
Authors: Shevchenko Nataliya , Ivashchenko Vladyslava , Rublevskyi Evgen , Zakora Oleksandr
Published: October 2023

The work uses AxSTREAM® software and documentation from SoftInWay (USA) for the design of turbomachines. National Technical University "KhPI" (Kharkov) received the right to use licensed software and documentation of the AxSTREAM® trademark in the educational process. The results of computer modeling and numerical studies were obtained in the process of preparing masters under the program "Industrial Mechanical Engineering". The work uses a modern approach to the design of flow parts of hydraulic machines. It is based on the joint solution of direct and inverse problems of hydrodynamics. The operation of the interface of the AxSTREAM® environment was tested to solve the problems of designing, calculating and optimizing the flow parts of hydraulic machines. The preliminary design module in the AxSTREAM® system is considered. The features of designing and numerical simulation of the flow of a viscous incompressible fluid of a centrifugal pump are considered. In the work, a design of a centrifugal pump for the given technical conditions was obtained. The energy parameters of the centrifugal pump have been calculated. A study was made of the influence of impeller turning on the energy characteristics of the pump. The calculation of the spatial flow in the flow part of the impeller of the pump NK 65/35-70 was performed. Comparison of the results of calculations by both methods with experiment is presented. The expediency of using semi-empirical models to obtain preliminary approximations on the optimization of the flow path has been confirmed. A review of modern packages of computational fluid dynamics is carried out.
DIAGNÓSTICO DEL USO DE ESTRATEGIAS AMBIENTALES PARA LA REHABILITACIÓN Y MANTENIMIENTO VIAL CON MATERIAL BITUMINOSO RECICLADO - MBR EN LA CIUDAD DE BOGOTÁ
Authors:   Corporación Universitaria Republicana, LONDOÑO GARCIA PAOLA ANDREA
Published: October 2023

The research is carried out in order to give a diagnosis for the use and rehabilitation and maintenance strategies of the road network in the city of Bogotá, providing a sustainable environmental initiative through recycled materials resulting from the asphalt layer removed from the demolition for the maintenance of the roads and from which MBR (recycled bituminous material) is obtained, which through a production process is transformed and mixed with other products, becoming an environmentally friendly alternative and the final product is used for rehabilitation and maintenance of rural roads within the city.
APLICACIÓN DE LA TEORÍA DE INVENTARIOS EN LA EMPRESA KJANTU COLLECTION S.A.C.
Authors:   Universidad Nacional del Centro del Perú, DIAZ VIVAS ESTEFANI , GRIJALVA DE LA CRUZ SOFIA , PILLORAZA ROJAS JESÚS , SANTIAGO TUMIALÁN JEAN
Published: October 2023

The present research work shows an application of a mathematical algorithm based on a linear programming model, with which a solution is given to the raw material inventory management problem presented by the company «Kjantu Collection» in its warehouses, in the It is not known how much should be invested in a given period or how much the total merchandise is valued. The objective of the research is to apply a raw material inventory control model using linear programming that contributes to decision making within the company Kjantu Collection S.A.C using the WinQSB software. In support of the solution of the model, the WinQSB software is used, whose results managed to obtain the optimal quantities for the company Kjantu Collection S.A.C with which the downtimes in the production of the different garments of the company will be eliminated, it was also possible to determine the costs per period in the production of each garment.
Necesidades de planificación territorial en el sector de las residencias de mayores en España (2021–2050)
Authors: Gurrutxaga Mikel
Published: October 2023

En un contexto de creciente demanda de servicios de atención a la dependencia, el impacto de la pandemia de COVID-19 en residencias de personas mayores en España ha puesto de manifiesto la necesidad de mejoras estructurales. Paralelamente, existen notables desigualdades territoriales de cobertura de plazas residenciales. Este estudio persigue estimar las necesidades de nuevas plazas residenciales para alcanzar la ratio media de los países de la OCDE –5 plazas por cada 100 personas de 65 y más años– a corto, medio y largo plazo, a escala nacional, provincial y de áreas urbanas y rurales. Se parte de los datos de residencias existentes, padrón y proyecciones de población. Los resultados muestran que sería necesario crear 255 000 nuevas plazas en el periodo 2021–2035 y otras 145 000 en el periodo 2035–2050 en España. El mayor déficit de plazas se concentra en grandes áreas urbanas y ciertas provincias litorales. La previsión a medio y largo plazo de residencias está siendo recogida en mayor medida en informes de entidades privadas que en planes de administraciones públicas competentes. Asimismo, para una adecuada planificación espacial de las residencias se requiere adoptar criterios de cercanía, integración en la comunidad y entornos que favorezcan el envejecimiento activo, la seguridad, la sociabilidad y la salud física y mental.
Optimizing the gene expression algorithm using the whale algorithm to predict the penetration rate of the tunnel boring machine
Authors: Noorian-Bidgoli Majid
Published: October 2023

Tunnel projects entail high levels of uncertainty due to vague geological conditions and the complexity of the mechanized tunneling process. The effectiveness of the tunnel-boring machine (TBM) is indispensable for the completion of any mechanical tunneling project. The capital costs and schedule of tunnel excavation may be reduced by precisely predicting TBM performance, particularly under certain rock mass conditions. This study attempts to present an optimized model of the gene expression algorithm using the whale optimization algorithm. The TBM drilling machine's penetration rate is a performance metric to provide a precise prediction target for the suggested models. Site surveys for the Qom metro line A project and numerous lab tests on the gathered rock samples led to the developing of a test database with 5742 data sets for modeling purposes. A combination of rock and machine characteristics having the largest impact on the drilling machine penetration rate was utilized to create intelligent models of drilling machine penetration rate relying on training and test patterns. A total of 7 parameters were used as input parameters. The prediction accuracy of the created models was also assessed and compared using several statistical indicators, including variance calculation, coefficient of determination, and root mean square error. Depending on the simulation results and the estimated values of the indices, the correlation coefficient values in the gene expression model and the model optimized by the whale algorithm were calculated as 0.79 and 0.91, respectively. This indicates the significant performance of the whale algorithm in optimizing the results of the gene expression algorithm aimed at predicting the penetration rate of the TBM.
Casual relationship between sepsis and cortical volume :A Bidirectional Two-sample Mendelian Randomization Study
Authors: Xu Wantong , Wu Zhounan , Jiang Zhongbiao , Guo Tao
Published: October 2023

Background
The correlation between sepsis and immediate or persistent brain dysfunction has gained considerable acknowledgment within the scientific realm nowadays. Yet, the precise causal impact of sepsis on cortical volume alterations remains uncertain.
Methods
This two-sample bidirectional Mendelian randomization (MR) study utilized sepsis summary statistics derived from the FinnGen consortium R8 release and genome-wide association study (GWAS) summary statistics for cortical volume across various areas from the UK Biobank. The investigation explored the causal interplay between sepsis and cortical volume, employing inverse variance weighting (IVW), MR-Egger regression, weighted median, weighted model, and MR-pleiotropy residual sum and outlier (MR-PRESSO) methods.
Result
The study uncovered significant correlations between sepsis subtypes and changes in cortical volume across distinct brain regions. Streptococcal sepsis showed negative associations with the cortical volume of the Left Precentral Gyrus (OR: 0.99, 95%CI: 0.99–0.99, P = 1.10E− 06) and Right Cingulate Gyrus (OR: 0.93, 95%CI: 0.91–0.95, P = 1.10E− 12), while a positive link emerged with the Right Supramarginal Gyrus (OR: 1.06, 95%CI: 1.05–1.08, P = 1.60E− 21). Similarly, Pneumococcal septicemia exhibited negative correlations with cortical volume in the Left Hippocampus (OR: 0.97, 95%CI: 0.96–0.98, P = 7.50E− 08) and Right Lingual Gyrus (OR: 0.98, 95%CI: 0.97–0.99, P = 3.00E− 10). Furthermore, Other sepsis risk displayed a negative association with the Left I-IV Cerebellum (OR: 0.92, 95%CI: 0.88–0.96, P = 6.00E− 05). In the reverse MR analysis, genetic predisposition towards the Right Cuneal Cortex (OR: 0.60, 95%CI: 0.46–0.79, P = 2.70E− 04) and Right Inferior Frontal Gyrus (OR: 0.61, 95%CI: 0.48–0.78, P = 9.10E− 05) correlated strongly with Streptococcal sepsis, while genetic predisposition to the Right Thalamus (OR: 0.58, 95%CI: 0.43–0.77, P = 2.60E− 04) was notably related to Pneumococcal septicemia.
Conclusion
This MR study successfully unveiled a causal connection between sepsis and cortical volume across distinct brain regions. To comprehensively grasp the mechanisms underlying the impact of sepsis on cortical volume, further research endeavors are warranted.
Preparation of Monophasic Yag Raw Material by Multi- Stage Process
Authors: Tinkova Vira , Kajan Juraj , Damazyan Grigori , Prnová Anna , Michálková Monika , Švančárek Peter , Gregor Tomáš , Hruška Branislav , Galusek Dušan
Published: October 2023

The paper deals with the study of the features of the process of YAG phase formation via the solid-state reaction (SSR) method according to the proposed multi-stage scheme, including three stages of various mechanical and thermal processing (pre-milling in a ball mill for 24, 48 and 72 h, as well as firing at 1150 °C, 1250 °C, and 1450 °C with intermediate grinding step). The commercial micrometer-sized Y2O3 and Al2O3 oxides were used as starting materials. The phase transformation was monitored by the X-ray diffraction in each synthesis stage. The microstructure and elemental distribution of samples were studied by scanning electron microscopy and energy-dispersive X-ray spectrometry.
During this work, we found the dual effects of partially reacted mixture grinding, which can accelerate or slow down the synthesis rate depending on the YAG content in the preceding stage. We have proposed a simple model including the concept of "critical YAG concentration".
When the lower limit of this parameter (over 60 %) is reached, grinding has a negative effect on the further course of the SSR. Carrying out the synthesis according to a three-stage scheme makes it possible to obtain a product with a YAG content above 90 %, regardless of the pre-milling time, and the use of a two-stage synthesis scheme provides a monophasic raw material (99 % of YAG) suitable for further single crystals growth. The increased efficiency of the multi-stage YAG synthesis scheme was demonstrated in comparison with the conventional one-stage obtaining process, allowing obtaining only up to 60 % of the target phase in the temperature range up to 1500 °C.
Ancient DNA supports that the evolution of Skin Tone in East Asians intensified after their split with Native Americans
Authors: Ferrando-Bernal Manuel
Published: October 2023

Skin tone has been deeply studied in European populations both using modern and ancient DNA. However, other populations are underrepresented in such studies. One such population is East Asians, for which, interestingly, it has been claimed to evolve light skin tones in parallel to Europeans. Moreover, it is not clear whether this happened before or after their split from Native Americans. Over the last few years, several studies have sequenced hundreds of ancient genomes belonging to East Asians ancient populations. Additionally, some variants have been associated with light skin in East Asians. To shed some light, I applied a Polygenic Risk Score for some of the variants associated with light skin, in 237 modern Native Americans and East Asian individuals and in more than 700 East Asians ancient samples. The results suggest that this phenotype may have started to evolve in the ancestors of East Asians and Native Americans but intensified after their split.
Classified Vpn Network Traffic Flow Using Time Related to Artificial Neural Network
Authors: MOHAMED Saad Abdalla Agaili , KURNAZ Sefer
Published: October 2023

In the rapidly evolving landscape of cybersecurity threats, Virtual Private Networks (VPNs) have become an essential tool for securing communication channels. However, the rising complexity and diversity of network attacks call for more sophisticated methods to identify and classify different types of VPN network traffic effectively. In this study, we propose a novel approach using Artificial Neural Networks (ANN) to classify VPN network traffic flows. The primary goal of this research is to develop a robust and efficient system capable of distinguishing between legitimate VPN traffic and potential malicious activities, such as intrusion attempts, data exfiltration, and denial-of-service attacks. We begin by collecting a diverse dataset of labeled VPN traffic flows encompassing various applications and usage patterns. Next, we design an ANN architecture tailored to handle the intricacies of encrypted traffic and effectively capture the subtle differences between benign and malicious activities. The neural network model incorporates several layers, including input, hidden, and output layers, to process and classify the encrypted packets accurately. To enhance the ANN's classification accuracy, we apply advanced feature extraction techniques, enabling the model to leverage both statistical and behavioral characteristics of the network traffic. Moreover, we implement state-of-the-art optimization algorithms to fine-tune the network parameters and improve its performance. We evaluate the proposed ANN-based classification system through extensive experimentation and performance analysis. The results demonstrate the model's effectiveness in accurately identifying and categorizing different VPN traffic types. Furthermore, we compare our ANN-based approach with existing methods, showcasing its superiority in terms of precision, recall, and F1-score with an accuracy of 98.79%. The contributions of this research are significant for enhancing the security of VPN networks and protecting against emerging cyber threats. By efficiently classifying VPN traffic flows, organizations can better safeguard their sensitive data, preserve network integrity, and respond promptly to potential security incidents. The findings of this study provide a valuable step forward in the realm of network security and lay the foundation for future advancements in ANN-based cybersecurity solutions.
Effects of soy lecithin on growth, stress resistance, digestive enzymes activity and antioxidant capacity in yellowfin seabream (Acanthopagrus latus) larvae
Authors: Morshedi Vahid , Mozanzadeh Mansour Torfi , Noori Farzaneh , Agh Naser , Jafari Fateme , Hamedi Shirin , Azodi Maryam , Moghadam Reza Afshar , Eryalcin Kamil Mert
Published: October 2023

Phospholipid (PL) is an essential nutrient that has vital effects on growth, stress resistance and early development in marine fish larvae. In this regard, a 30-day feeding experiment was conducted in order to examine the effects of live prey enrichment with graded levels of soy lecithin (SL) on some physiological responses of Acanthopagrus latus larvae. Four experimental emulsions levels of SL were used to enrich Rotifer and Artemia including very low (2%, N), low (4%, L), medium (8%, M) and high (12%, H). Newly hatched larvae were distributed into twelve 250-L cylindrical tanks with an initial density of 15000 larvae in each tank that was supplied with natural seawater (23 ± 1 ºC; 40.0 ± 1.0 g L-1). The green water method was used for larviculture and live prey was given to larvae two times daily. Larvae fed 4% SL containing live prey significantly had higher wet weight gain than other treatments. Air exposure and osmotic activity tests were also performed to detect larval resistance to stress. Larvae fed 8% and 12% SL containing live prey had higher survival compared to the other two groups. The accumulation of arachidonic ARA and docosahexaenoic acids was increased in the larval whole body fed high SL-supplemented live foods. Alkaline phosphatase and aminopeptidase N activities in the guts brush border membrane of larvae in M and H groups were higher than other treatments. The trypsin and chymotrypsin activities in the N group were lower than in other treatments. The highest and lowest amylase activities were in the H and N groups, respectively. The activity of catalase and glutathione reductase in the whole body of the M group was higher than the N treatment and other groups had intermediate values. Total antioxidant capacity in the whole body of larvae in the N group was lower than in the other treatments. In summary, moderate levels of SL (4–8%) are suggested for the enrichment of live foods in A. latus.
Health-related Quality of Life of Children with X-linked Hypophosphatemia in Germany in the Burosumab Era
Authors: Klein Martin , Obermaier Michael , Mutze Helena , Wilden Sophia Maria , Rehberg Mirko , Schlingmann Karl Peter , Schmidt Dorothee , Metzing Oliver , Hübner Angela , Richter-Unruh Anette , Kemper Markus , Weitz Marcus , Wühl Elke , Jorch Norbert , Patzer Ludwig , Freiberg Clemens , Heger Sabine , Ziviknjak Miroslav , Schnabel Dirk , Haffner Dieter
Published: October 2023

Background
X-linked hypophosphatemia (XLH) is a rare inherited phosphate-wasting disorder associated with bone and dental complications. Health-related quality of life (HRQoL) is reduced in XLH patients on conventional treatment with phosphate supplements and active vitamin D, while information on patients treated with burosumab is rare.
Methods
HRQoL was assessed in 63 pediatric XLH patients participating in a prospective, observational study and patient registry in Germany using the KIDSCREEN-52 survey instrument and standardized qualitative interviews.
Results
The median age of the XLH patients was 13.2 years (interquartile range 10.6–14.6). At the time of the survey, 55 (87%) patients received burosumab and 8 (13%) conventional treatment. Forty-six patients (84%) currently being treated with burosumab previously received conventional treatment. Overall, HRQoL was average compared to German reference values (mean ± SD: self-report: 53.36 ± 6.47; caregivers' proxy: 51.33 ± 7.15) and even slightly above average in some dimensions, including physical, mental and social well-being. In general, XLH patients rated their own HRQoL higher than their caregivers. In qualitative interviews patients and caregivers reported that, compared with conventional therapy, treatment with burosumab reduced stress, bone pain, and fatigue, improved physical health and increased social acceptance by peers and the school environment.
Conclusions
In this real-world study in pediatric XLH patients, HRQoL was average or even slightly above that of the general population, likely due to the fact that the vast majority of patients had their treatment modality switched from conventional treatment to burosumab resulting in improved physical health and well-being.