bluuebunny/crossref_metadata_2025 huggingface dataset:
Pourquoi la rénovation énergétique a-t-elle besoin d’une politique opérationnelle en matière de ressources humaines ?
Authors: Naert Dominique , Meynier-Millefert Marjolaine
Published: May 2022

Alors que la demande de rénovation devient de plus en plus consensuelle et pressante, la question de l’offre de services artisanaux adaptés devient, quant à elle, plus cruciale. Si nous voulons réussir la rénovation énergétique de près de 5 milliards de m 2 de bâtiments en France d’ici à 2050, condition sine qua non de l’atteinte des objectifs fixés en matière de neutralité carbone, il est urgent que les acteurs de la filière Bâtiment et les acteurs publics élaborent une stratégie concertée afin d’accroître la productivité des artisans et des ouvriers du secteur, qui sont les acteurs à 95 % de la rénovation énergétique en France… Il faut également mettre en œuvre une campagne participant à l’attractivité des métiers opérationnels du bâtiment, une pédagogie d’apprentissage ciblée et un processus de montée en compétence des professionnels qualifiés. Dès lors, nous devons réaliser un état des lieux objectif de nos capacités de production et engager, à partir de celui-ci et sans attendre, les réformes qui doivent permettre une double révolution : celle d’une croissance massive des offres globales de rénovation et, en parallèle, celle de la transformation profonde des habitudes et des usages. La massification des opérations de rénovation est mise sur les rails. Elle se heurte néanmoins en parallèle à des évolutions réglementaires tout aussi radicales et rapides, qui viennent bousculer les métiers et l’organisation de la filière appelée à porter cette massification. C’est une recherche concrète du progrès technologique et social qu’il faut entreprendre, une démarche de développement qui sera dès lors véritablement durable. Pour le moment, rien ne laisse à penser que les objectifs de la neutralité carbone dans l’immobilier et le bâtiment seront atteints en 2050 : le compte n’y est pas. L’équation n’est pas encore résolue… Il nous semble donc temps de décréter un grand état des lieux de la formation initiale et continue, et de mettre en place une task force sur l’emploi dans le bâtiment à l’image de celle qui l’a été pour le financement ou le tiers-financement de la rénovation énergétique. Il nous faut observer et relever les bonnes pratiques à l’instar du rapport « Rénover mieux : leçons d’Europe » présenté par le Haut Conseil pour le climat, et accompagner subtilement la transition en permettant un accroissement immédiat de la productivité des artisans et des ouvriers du bâtiment. Dans cet article, nous proposons des pistes de réflexion qui devraient permettre d’ouvrir au plus vite le débat sur ces questions.
Accélérer la rénovation en Europe grâce à l’intelligence artificielle
Authors: Panissod Quentin , Gomes Lopes Pedro
Published: May 2022

Le projet RenovAIte est une initiative franco-allemande visant à accélérer la rénovation des bâtiments et des routes et à en améliorer la performance environnementale et économique grâce à l’intelligence artificielle. Ce projet part d’une situation à première vue paradoxale réunissant, d’une part, l’urgence climatique et, d’autre part, la nécessité d’investissements massifs dans le développement de technologies d’intelligence artificielle voraces en ressources 1 . De plus, ces technologies ne figurent pas parmi les besoins clés pour l’accélération de la rénovation énergétique. C’est pourtant un levier qui peut changer la donne et a réussi à réunir un consortium éclectique autour de l’innovation pour la rénovation : la plateforme d’innovation Leonard et plusieurs autres entités du groupe Vinci, le groupe Action Logement, le laboratoire de recherche OFFIS, le centre d’innovation VIA IMC et la plateforme d’intelligence artificielle souveraine française, ALEIA. Ensemble, nous allons engager pour 8 millions d’euros de travaux de recherche et développement pour partir à la conquête de gains en performance environnementale et économique à travers la rénovation des logements et des routes. Dans cet article, nous décrivons les enjeux de cette démarche, les différentes applications d’intel- ligence artificielle existant en matière de rénovation et le contenu du projet RenovAIte, dont les premiers travaux qui ont débuté en mars 2022 se poursuivront jusqu’à mars 2025. C’est aussi un appel à contributions et à une mutualisation des efforts entre tous les acteurs européens du secteur dans le but de partager nos pratiques et créer un leader mondial sur ce champ d’application.
Las epidemias de cólera en Estambul Otomano tardío, la atención médica y las Hermanas de la Caridad Católicas francesas
Authors: Gülser İlikan Rasimoğlu Ceren
Published: May 2022

Este artículo trata sobre los servicios de salud brindados por las Hermanas de la Caridad (Filles de la Charité) durante las epidemias de cólera en instituciones abiertas y administradas en el siglo XIX en Estambul como parte de sus misiones orientales. Los anuarios en los que se recopilaron informes y cartas y se dirigieron al centro de la congregación en París, Annales de la Congrégation de la Mission et des Filles de la Charité (ACM), se utilizan como fuentes primarias. Este estudio tiene como objetivo evaluar las pandemias de cólera en el marco de la historia mundial y el contexto otomano haciendo una contribución a las geografías históricas existentes del cólera, además de la literatura que acentúa la importancia de la agencia de las mujeres en el contexto otomano, con base en hallazgos originales. El artículo evalúa cómo afectó el cólera a Estambul y cómo se enfrentó la enfermedad, a través de las conexiones entre las hermanas y los actores locales. El estudio también muestra que el ejemplo otomano no fue solo el resultado de las experiencias occidentales, sino que, aunque fue parte de una amplia historia de pandemias, sus actores tuvieron sus propios desarrollos únicos moldeados por escenarios y eventos imperiales y locales.
Composition floristique et diversité du peuplement ligneux en zone de savane soudanienne de la Côte d’Ivoire
Authors: Missa Koffi , Soro Dramane , Dro Bernadin , Koné Mamidou Witabouna
Published: May 2022

En étudiant le potentiel floristique des ligneux de la région ivoirienne du Tchologo, cet article vient renforcer la connaissance de la flore ligneuse des savanes en Côte d'Ivoire. À cet effet, les espèces ligneuses ont été identifiées et mesurées dans des surfaces d’un hectare (200 mètres par 50 mètres) aux abords des trois principaux axes de la région d’étude. Cet inventaire a montré que la zone est riche de 88 espèces, réparties dans 69 genres et 30 familles. Le nombre moyen d’espèces varie de 19,20 ± 4,7 sur l’axe Ferkessedougou-Tafiré à 22,66±2,77 sur l’axe Korhogo-Ferkessédougou. Les familles dominantes sont les Caesalpiniaceae (13%), les Combretaceae (8%) et les Euphorbiaceae (7%). La comparaison de la densité des tiges a indiqué que l’axe Korhogo-Ferkessédougou présente la plus forte valeur. L’analyse de la diversité floristique a montré une diversité plus élevée aux abords de l’axe Ferkessedougou-Tafiré. Ces résultats attestent que la flore soudanienne présente une grande valeur écologique.
Constructing Technology Commercialization Capability
Authors: Cai Li , Lu Shan , Chen Biao
Published: May 2022

In the era of big data-driven digital economies, technology commercialization capability has become the lifeblood of high-tech enterprises to shape competitive advantage and achieve multiplier growth, while the related research is still limited. Drawing on the dynamic capability theory, this study asserts that external user engagement provides an imperative way to enhance technology commercialization capability. Although the highly complicated external environment may weaken this link, high-tech enterprises’ own big data analytics capability contributes to effectively coping with the unpredictable changing environment, thereby amplifying the brighter side of user engagement. The moderated moderation model and hypotheses were supported by the unique surveys of 216 high-tech enterprises. Further, the findings broaden the vision of related research fields, and provide meaningful practical guidance for strategic decision-making and dynamic capability constructing of high-tech enterprises in the new era.
Motivations for entering a physical education teacher training program in Chile
Authors: Soza María Magdalena Pereda , Schilling Lara Caroll Alejandra , Carvalho Ricardo de Souza
Published: May 2022

Physical Education teacher training programs in Chile have a high demand for enrollment and is recognized as one of the attractive professions for young people. The purpouse of this study is to know the reasons that lead young Chileans to choose the Physical Education teacher training program at a regional university, in the Maule region, Chile. The research was a mixed sequential one, since it was characterized by a first stage, where quantitative data were collected and analyzed, followed by another, where qualitative data were collected and interpreted. At the quantitative part of the study 146 students (54 female and 89 male) answered a questionnaire, and at the qualitative part 6 students (3 men and 3 women) participated in a focus group interview. Previous participation in sport, interest related to a physically active lifestile, and the pleasure of teaching are shown in the results. As conclusions, the students choose to enroll in a physical education teaching program motivated by previous sports and physical activity experiences, and the desire to teach values through sport.
Exploring Customers’ Co-Learning Practices in Co-Creating Value with Self-Service Technologies
Authors: Galdolage B. S.
Published: May 2022

Value co-creation is becoming a prominent business practice, particularly in the service sector, demarcating a diversion of business strategies to produce mutually valued outcomes. Self-service technology, as a technology-based service encounter, allow customers to perform many service transactions independently.  Customers’ collaborative learning becomes essential to successfully co-create value in self-service technologies since they perform service transactions on their own without the support of organizations’ service employees.  However, scholarly attention given to understanding customer co-learning in value co-creation at SSTs are sporadic.  Therefore, this study aims at exploring customer co-learning in   self-service technologies. Aligning with the research objectives, qualitative methodology has been adopted. Accordingly, semi structured interviews were conducted, and data were analyzed using Thematic analysis approach. The study identified five customer co-learning practices in self-service technologies; searching information, sharing information, recalling information, following instructions, and providing feedback. Further, the study extended to categorize customers based on their co-learning abilities and performance at SSTs and three types of customer groups were recognized as ‘Dire performer’, ‘Fair performer’ and ‘Full performer’. Business organizations can effectively use this understanding to provide customer learning, conduct training programs, and design communication and promotional programs targeting different customer groups, ensuring superior customer experiences in self- service technologies.
Consumers’ Attitude Towards Organic Products -The Moderating Role of Health Consciousness
Authors: Rathna G. Anitha , Sumathy M.
Published: May 2022

During the last years, we have observed that emergent environmental protection along with health concerns which directed the people to choose recent agricultural practices. There is a direct and indirect impact of health consciousness, to analysis the impact on attitude towards organic foods Nagaraj, S. (2021). In this study, health consciousness is taken as a moderating variable because nowadays consumers are facing various diseases like cancer, obesity, diabetes, etc. due to unhealthy food practices followed by consumers.  A structured questioner method was used to collect data from 534 consumers, and the data was collected by using a convenient sampling method. To find out the impact of consumer willingness to consume such foods, using regression analysis to find out the consumers' attitude towards organic foods. By using rotated component matrix grouping the variables under Six –factors like Healthy Life Style, Healthy Knowledge, Health concern, Medication, Health & nutritious value, Health care & Work schedule. All these variables are considered to be moderating variables. The present study attempts to find out the consumers' attitude towards organic food by using a moderating variable to assess the role of health consciousness.
Remimazolam – current knowledge on a new intravenous benzodiazepine anesthetic agent
Authors: Kim Seong-Hyop , Fechner Jörg
Published: May 2022

Intravenous anesthetic agents such as midazolam, propofol, and ketamine are routinely used to provide anesthesia and sedation. They have been shown to effectively induce and maintain amnesia, sedation, and hypnosis in various patient groups and clinical settings. However, all anesthetic agents have the potential to cause unwanted side effects such as hemodynamic instability, respiratory depression, or slow recovery due to prolonged post-procedural sedation. Remimazolam, a recently approved benzodiazepine for general anesthesia and procedural sedation in Korea, has been successfully used for these purposes. To date, inconclusive knowledge has been obtained regarding the use of remimazolam in different patient populations and under various surgical conditions. With respect to the specific pharmacokinetic and pharmacodynamic characteristics of remimazolam, the use of remimazolam is expected to increase providing safe general anesthesia and sedation. This review aims to provide an overview of the basic and clinical pharmacology of remimazolam and to compare it with midazolam and propofol.
A prospective study on the efficacy and safety of fractional carbon dioxide laser in the treatment of post-acne scars
Authors: Sundaram Gayathri , Vellaisamy Seethalakshmi G. , Gopalan Kannan , Manickam Navakumar
Published: May 2022

Introduction

Acne scars can play havoc with the social functioning of the patient leading to severe depression with reduced quality of life. Fractional CO2 laser provides a fine balance between the undesirable side effects of ablative lasers and the limited efficacy of nonablative lasers.

Objective

The present study was conducted to evaluate the efficacy and safety of fractional CO2 laser in the treatment of acne scars.

Patients and methods

Fractional CO2 laser treatment performed on 30 patients with atrophic acne scar by different protocols depending on the type and its depth. Results were assessed based on serial photographs, clinical improvement, and physician’s global assessment scale.

Results

Of the 30 participants, 27 completed all three sessions. Out of the 27 patients in the final follow-up, three (10%) had excellent improvement of which two had mild acne scar and one had moderate scar before treatment; 16 (59.2%) had good response of which 13 had moderate acne scar and three had mild scar and eight (29.7%) had fair response of which six had moderate scars and two had mild scars.

Conclusion

Fractional CO2 laser as monotherapy in the treatment of mild-to-moderate post-acne scars seems to be effective with good patient satisfaction and reduced side effect profile. In case of severe acne scars, fractional CO2 laser can be used as a combined procedure along with other therapeutic modalities like subcision, platelet-rich plasma, and TCA CROSS (chemical reconstruction of skin scars using trichloroacetic acid) techniques.
An observational study of Helicobacter pylori infection in patients with chronic plaque psoriasis
Authors: Anas Mohammed , Arora Tarlok C. , Gaind Rajni , Matlani Monika
Published: May 2022

Objectives

To determine the prevalence of Helicobacter pylori infection in patients with chronic plaque psoriasis and to determine the association of H. pylori infection with the severity of chronic plaque psoriasis.

Patients and methods

The prospective case–control pilot study was conducted in the outpatient Department of Dermatology from November 2017 to April 2019. A total of 50 patients with chronic plaque psoriasis and 50 consenting healthy controls were included in the study. A cutaneous examination of the morphology, site, and extent of the lesions was done. Psoriasis area and severity index scores were calculated for all patients. H. pylori stool antigen test was performed for all cases and controls. The data were entered into MS Excel spreadsheet, and analysis was done using the Statistical Package for the Social Sciences (SPSS), version 21.0.

Results

The mean age of patients with psoriasis was 37.24±11.7 years, with 64% males and 36% females. H. pylori was positive in 24/50 patients with psoriasis. Compared with controls, patients with psoriasis had significantly higher H. pylori positivity rate (48 vs. 26%, P=0.023). Compared with the patients with H. pylori negative status (n=26), H. pylori positivity (n=24) showed significant association with site and disease progression (P=0.016) but not with disease duration (P=0.907). The median psoriasis area and severity index score in H. pylori-positive patients was significantly higher than that in patients with negative H. pylori (13.55 vs. 4.65, P=0.002).

Conclusion

The small number of patients studied showed that H. pylori infection is associated with psoriasis, with the progression and the severity of psoriasis, bearing a direct association with increased positivity for H. pylori.
Median canaliform dystrophy of Heller
Authors: Sethy Mitanjali , Mandava Venkatesh , Sachan Suvigya
Published: May 2022

Median canaliform nail dystrophy of Heller (MCND), also known as dystrophia unguis mediana canaliformis, solenonychia, and nevus striatus unguis, is an uncommon nail disorder characterized by a paramedian or midline ridge or groove or canal formation in the nail plate of one or both the thumbnails. It rarely involves the other fingernails or toenails. Most of the cases of MCND are idiopathic. However, it may also be secondary to traumatic injury to the base of the nail, subungual skin tumors such as glomus or myxoid tumor, and the use of drugs like oral isotretinoin. Although it is believed to be an acquired condition, few familial cases have also been reported. Here we report three cases of MCND involving fingernails and toenails.
Palmar wart with ‘Myrmecia’ inclusions on histopathology – recap of an unusual entity
Authors: Devra Anshu Gupta , Mittal Salony , Tiwari Awantika
Published: May 2022

Cutaneous warts are a common skin condition affecting children and young adults and signify infection with human papillomavirus. They are of various types and show association with specific viral genotypes. The aim of this case report is to highlight one such case of deep palmoplantar wart also known as ‘Myrmecia wart’ because of its very peculiar clinical and histopathologic findings. A young male in his mid-20s presented with a warty growth in the index finger of his right hand. Biopsy and subsequent histopathological examination confirmed its categorization as Myrmecia wart. A thorough account of its typical cytopathic effects observed in histopathology as well its differentiating features from other common warts like verruca vulgaris and molluscum contagiosum infection on microscopy is warranted. Further, not so frequent incidence merits detailed review of this entity.
Tissue and serum lipoxin A4 levels in psoriasis patients and their relation with disease severity
Authors: Naguib Rehab Mohamed , Al Nemr Hanan Abo Zaid Mohamed , Rashed Laila Ahmed , Naguib Reham William
Published: May 2022

Background

Psoriasis disease is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Lipoxin A4 plays a role in improvement of psoriasis cases, it blocks the production of the proinflammatory cytokine tumor necrosis factor with increasing the production of the anti-inflammatory cytokine, c–c chemochine receptor-5 by T lymphocytes, and it reduces the perception of pain due to inflammation.

Aim

Detection of the expression of lipoxin A4 in the tissue and serum of psoriatic patients as compared with normal-control persons to investigate the possible role of lipoxin A4 in the psoriasis pathogenesis and its correlation with disease severity.

Patients and methods

The present study included 25 psoriatic patients and 25 age, sex-matched healthy controls. Four-mm punch-skin biopsy was taken from patients (psoriatic lesion) and control persons and it was kept in lysis solution for the stability of the studied parameters and it was kept frozen at –80°C till analysis of lipoxin A4 by PCR. Peripheral blood samples for detection of serum lipoxin A4 were taken. Blood samples were centrifuged and the serum was stored at –80°C and used for enzyme-linked immunosorbent assay.

Results

Psoriatic patients had significantly lower tissue and serum lipoxin A4 levels as compared with normal-control persons.

Conclusions

Lipoxin A4 could contribute to psoriasis pathogenesis through its immunomodulatory role.
Autophagy-related gene 16L1 value in chronic plaque psoriasis
Authors: Naguib Rehab M. , El-Rifaie Abd-El Aziz , Eissa Eman A.Z. , Rashed Laila A.
Published: May 2022

Background

Psoriasis is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Autophagy is a strictly regulated lysosomal degradation pathway that is crucial for maintaining intracellular homeostasis and normal development. Dysregulation of autophagy-related genes has been recognized to increase susceptibility to diseases, such as inflammation, cancer, and autoimmune disorders.

Aim

Our study aimed to detect the expression of the autophagy-related gene 16L1 (ATG 16L) in psoriasis patients compared with normal controls to investigate the role of autophagy in the pathogenesis of this disease.

Patients and methods

This case–control study included 30 psoriasis patients and 30 healthy controls. Punch skin biopsies of 4 mm were taken from psoriatic lesions and then from the controls and they were kept in a lysis solution for the stability of the studied parameters and were kept frozen at –80°C till analysis of ATG 16L using real-time PCR.

Results

The level of the ATG 16L1 in the lesional skin of psoriasis was significantly increased compared with normal controls (P<0.001).

Limitation

Limited number of patients were included in this study (30 patients).

Conclusion

Autophagy process may play an important role in the pathogenesis of psoriasis disease.
Assessment of serum fatty acid-binding protein 4 and adiponectin levels in psoriasis patients and their correlation with disease severity
Authors: Tawfik Noha Z. , Gomaa Amal H.A. , Hassan Ranya , El-alfy Basma A. , Rageh Sara A. , Ismail Nader A.
Published: May 2022

Background

Psoriasis is a chronic multifactorial autoimmune disease that has significant impacts on the quality of life. Adiponectin exhibits important anti-inflammatory, antioxidants, and antidiabetic effects. The role of fatty acid-binding protein 4 (FABP4) in psoriasis may be linked to tumor necrosis factor-α, which is one of the main cytokines contributing to the etiopathogenesis of this disease.

Aim

To understand the role of serum levels of FABP4 and adiponectin in disease pathogenesis and their correlation to disease severity.

Patients and methods

A case–control study was conducted on two groups. The first group included 35 psoriatic patients; the second group included 35 healthy volunteers matched for age, sex, and weight. Serum FABP4 and adiponectin levels were evaluated.

Results

The mean level of adiponectin among the patients was 4.3±1.4 ng/dl. The mean level of FABP4 among controls was 2.1±1.5 ng/dl. The difference between both groups was statistically significant (P<0.05).

Conclusion

In this study, serum FABP4 level and adiponectin levels were decreased in patients with psoriasis with no relation to disease severity. So, they cannot be used as clinical biomarkers of inflammation and disease activity in psoriasis
Evaluation of the Ameliorative Roles of Vitamins A, C, and E on Alanine Aminotransferase Production in Clarias gariepinus (Burchell, 1822) Fingerlings Exposed to Lead Nitrate
Authors: Samuel Patrick Ozovehe , Arimoro F. O. , Ayanwale A. V. , Mohammad H. L.
Published: May 2022

Background:

Pollutants from industrial and commercial usage of chemicals all over the world that usually lead to release of myriads of toxic pollutants such as lead call for concern.

Aim and Objective:

The effects of lead nitrate on the production of antioxidants such as Alanine aminotransferase (ALT) in Clarias gariepinus and how such effects can be ameliorated through administration of vitamins were investigated.

Materials and Methods:

C. gariepinus fingerlings (whose initial weight ranged from 3 to 11 g) were exposed to sublethal concentrations of Pb (00, 26 mg/L, 44 mg/L, 61 mg/L, and 79 mg/L) with replicate in each case. 26 mg/L of the vitamins was administered across all bud. Fresh concentrations of both toxicant and vitamins were administered every 72 h for a period of 12 weeks every time the water medium was changed. The various treatments group include Pb (Pb only), PbVA (Pb + vitamin A), PbVC ((Pb + vitamin C), and PbVE (Pb + vitamin E) with T1-T4 and replicates in each case. Three samples of the fish were randomly selected and sacrificed from each aquarium tank every 2 weeks of the exposure period. The gills, kidneys, and liver were excised from these specimens and homogenized in sodium phosphate buffer. These were then assayed for ALT production levels in each case. The data generated were subjected to one-way analysis of variance and considered significant at P ≤ 0.05.

Results:

In samples exposed to Pb only group, the ALT production levels indicated that the highest ALT produced in the liver, kidney, and gills was 87.20 ± 0.15 nM/mg, 65.76 ± 0.20 nM/mg, and 69.92 ± 0.05 nM/mg, respectively. Samples exposed to PbVA indicated that the highest ALT produced in the liver, kidney, and gills was 77.12 ± 0.20 nM/mg, 84.75 ± 0.10 nM/mg, and 70.43 ± 0.24 nM/mg, respectively.

Conclusions and Recommendation:

In samples exposed to PbVC, the highest ALT produced in the liver, kidney, and gills was 86.53 ± 0.05 nM/mg, 63.48 ± 0.15 nM/mg, and 66.53 ± 0.15 nM/mg, respectively. In samples exposed to PbVE, the highest ALT produced in the liver, kidney, and gills was 73.82 ± 0.15 nM/mg, 78.05 ± 0.15 nM/mg, and 73.31 ± 0.05 nM/mg, respectively. The samples of the fish exposed to sublethal concentrations of the toxicant in the various treatments displayed varying levels of production of the enzyme with higher production levels mostly at higher concentrations of the toxicant. In the Pb only and PbVC groups, the liver of the samples produced the highest ALT, while the kidneys did same in the PbVA and PbVE groups. The high levels of production of the enzyme, especially in higher concentrations suggest physiological imbalances due to the presence of the toxicant.
Effects of Zingiber officinale Aqueous Leaf Extract on Vincristine-Induced Kidney Damage in Adult Wistar Rats
Authors: Ehimigbai Richard O. Agbonluai , Akpobaro Afokeoghene Eseoghene
Published: May 2022

Background:

Vincristine, although used as a chemotherapy drug, has been reported to induce nephrotoxicity, while Zingiber officinale, a medicinal plant, possesses antioxidant, antiapoptotic, and antitumorigenic properties.

Aim and Objectives:

In this study, we examined the effects of Z. officinale against vincristine-induced kidney damage by analyzing renal function, enzymatic antioxidants, and renal tissue.

Materials and Methods:

Thirty adult Wistar rats, weighing between 140 g and 185 g, were assigned into six groups of five animals each. Groups A, B, C, D, E, and F received 1 ml of distilled water, 200 mg/kg of Z. officinale aqueous extract, 1000 mg/kg of Z. officinale aqueous extract, 50 μg/kg of vincristine only, 200 mg/kg of Z. officinale aqueous extract and 50 μg/kg of vincristine, and 1000 mg/kg of Z. officinale aqueous extract and 50 μg/kg of vincristine, respectively. Administration of vincristine was by a 10-day intraperitoneal injection, while that of Z. officinale was by gavage, for a period of 28 days. Food and water were provided across all groups, ad libitum.

Results:

Vincristine significantly (P < 0.05) increased the levels of creatinine, urea, chloride, and malondialdehyde while having a reducing effect on the levels of superoxide dismutase and catalase. The histology revealed that vincristine caused a distortion of the renal architecture.

Conclusion:

The administration of Z. officinale mitigated the aforementioned debilitating effects of vincristine.
Antifibrotic Potential of Tetracarpidium conophorum (African Walnut) Leaves Extract on Diethylstilbestrol-Induced Rat Model of Uterine Fibroid
Authors: Oyinloye Esther Y. , Alabi Mutiu A. , Ajayi Kofoworola , Ajose Dolapo , Adeyemi Ayobola B. , Ajani Emmanuel O.
Published: May 2022

Background:

The increased prevalence of uterine fibroid (UF) and its life-threatening impact among women of reproductive age led to the development of this study. The study investigated the antifibrotic potential of Tetracarpidium conophorum aqueous extract on UF-induced rats.

Materials and Methods:

Sixty-four female Wistar rats, with an average weight of 200 g, were used for the study. The rats were randomly divided into eight groups of eight animals each. UF was induced by oral administration of diethylstilbestrol (DES) and intramuscular injection of progesterone at dosages 1.35 and 1.0 mg/kg body weight, respectively. Group 1 was administered normal saline orally for 8 weeks. Groups 2 and 3 were treated with progesterone and a combination of DES and progesterone, respectively. Groups 4 and 5 were pretreated with 200 and 400 mg/kg T. conophorum extract, respectively, for 3 weeks before the administration of DES and progesterone for 5 weeks. Groups 6 and 7 were administered DES and progesterone for 5 weeks before being treated with 200 and 400 mg/kg T. conophorum extract, respectively, for 3 weeks. Group 8 was the self-recovery group-administered DES and progesterone for 5 weeks after which they were given normal saline orally for 3 weeks.

Results:

After the treatment period, the rats were euthanized, and blood was collected, while the uteruses were harvested. Co-administration of DES and progesterone produces UF conditions. However, pre- and post-treatment with 200 mg/kg of extract mitigated the effects that were induced by DES and progesterone, but no remarkable preventive and curative effects were observed with the higher dosage (400 mg/kg). There were a reduction of the serum prolactin level in the treatment groups and an increased serum progesterone level in the posttreatment group.

Conclusion:

The study has shown that T. conophorum has both preventive and curative effects on UF at low dosage (200 mg/kg).
A complete review on floating drug delivery system
Authors: Chauhan Priyanshi , Kumar Kapil , Khairiya Dipti , Teotia Deepak
Published: May 2022

The aim of writing this review on FDDS to focus on the system of floatation to attain gastric retention, or to attain desired concentration of drug in blood or tissues. Today’s condition focus on the formulation of the FDDS. Effervescent FDDS release carbon dioxide gas, thus decreases the density of the system and remain floatable  in stomach for a longer period of time and released the drug at slowly conveniently  in order to improve bioavailability of drug. The study summarizes the application of the system, factors that affect floating system, mechanism, advantages, disadvantages and preparation.
GESTÃO ESTRATÉGICA DE CUSTOS: UM ESTUDO SOBRE SUA APLICAÇAO E UTILIZAÇÃO EM MICRO E PEQUENAS EMPRESAS DO SETOR DE SERVIÇOS
Authors: Mendes Renato Cruz , Elias Montibeler Everlam
Published: May 2022

Em um ambiente de negócios altamente competitivo, com grandes avanços e inovações tecnológicas, somando ainda ao aumento contínuo do nível de exigência dos clientes, é comum por parte das organizações a adoção de práticas e estratégias que assegurem a continuidade de suas operações atendendo às demandas mercadológicas e possibilitem a competitividade frente aos seus concorrentes. Assim, o objetivo principal deste estudo foi compreender de que forma a Gestão Estratégica de Custos é utilizada e aplicada em micro e pequenas empresas do Setor de Serviços. Para alcançar este resultado, utilizou-se o questionário como ferramenta de coleta de dados, aplicando-o para o número amostral de 68 gestores pertencentes às delimitações setorial, espacial e de porte. Após traçar o perfil das empresas pesquisadas e demonstrar suas informações sobre as estratégias utilizadas e a gestão de seus custos organizacionais foi possível concluir que mais de 70% das MPE’s elaboram estratégias com o objetivo de manter a competitividade frente aos concorrentes e que a gestão dos recursos financeiros constituiu o foco principal para elaboração de estratégias de menos de 20% das mesmas. Além disso, constatou-se que seus gestores não possuem conhecimentos e informações necessárias para a implantação e utilização eficaz da Gestão Estratégica de Custos. Por fim, aplicou-se a análise multivariada fatorial, que reduziu as variáveis em dois fatores principais: gestão operacional, composto pelas ferramentas de planejamento que integram à análise custo-volume-lucro e classificação operacional, composto pelas variáveis de classificação dos custos quanto à identificação e ao volume de produção.
SISTEMAS DE CUSTOS EM ORGANIZAÇÕES HOSPITALARES: ESTUDO DE CASOS NO MUNICÍPIO DE CASCÁVEL/PR
Authors: Capponi Neiva Feuser , Silva Eduardo Damião da
Published: May 2022

O objetivo deste artigo é identificar como os sistemas de custeios contribuem para a melhoria do desempenho econômico e financeiro, na percepção dos seus gestores. Trata-se de uma pesquisa qualitativa aplicando o estudo multicasos de natureza descritiva, ocorrido no período de junho de 2014 a janeiro de 2015. Utilizou-se um estudo longitudinal com um corte transversal, correspondendo ao período em que o Sistema de Custeio foi implementado até a data limite de dezembro de 2013. Uma vez que o pré-requisito básico eram organizações com algum tipo de sistema de custos implantado, os dados foram coletados através de pesquisa documental e entrevistas por meio de roteiro semiestruturado a três gestores de hospitais privados. A partir da análise verificou-se a estruturação do sistema de custos, as ações desenvolvidas, as dificuldades no alcance dos objetivos, os constantes treinamentos às equipes e os resultados alcançados quanto ao desempenho econômico e financeiro, através da análise da lucratividade e da rentabilidade. Como resultado percebeu-se a contribuição no levantamento das diárias e taxas, necessárias à formação do gasto com o paciente, fundamentando os gestores quanto às negociações com as operadoras e o SUS, tendo como consequência a melhoria em sua lucratividade e rentabilidade.
Perangkat Pembelajaran Metode Inquiry Based Learning untuk Meningkatkan Minat dan Prestasi Belajar Matematika
Authors: Lusyana Evvy , Rahmah Silviani Tri , Ralmugiz Uke , Fitriani Fitriani
Published: May 2022

Tujuan penelitian ini adalah untuk menghasilkan perangkat pembelajaran metematika berbasis inquiry based learning untuk meningkatkan minat dan prestasi belajar siswa yang valid, praktis dan efektif. Penelitian ini merupakan penelitian pengembangan yang menggunakan model pengembangan Plomp dengan tahapan meliputi: (1) studi pendahuluan mencakup analisis kebutuhan dan situasi; (2) tahap perancangan dan pengembangan prototype; (3) tahap penilaian mencakup validasi ahli dan uji coba produk. Instrumen penelitian terdiri dari: (1) lembar validasi RPP dan LKS; (2) lembar penilaian kepraktisan dari guru dan siswa; (3) lembar observasi keterlaksanaan pembelajaran; (4) angket minat; dan (5) prestasi belajar. Subjek uji coba yaitu guru dan siswa MTsN 1 Kota Bima dan SMP N 1 Mantingan. Analisis rata-rata dilakukan dengan cara deskriptif. Hasil penelitian menunjukkan bahwa perangkat pembelajaran matematika berbasis inquiry memenuhi kriteria valid, praktis dan efektif.
Chia Tohumu ve Probiyotik/ Enzim İlavesinin Ayrı ve Kombine Olarak Tuj Koyunları Rasyonlarında Kullanımının Performans, Rumen ve Bazı Kan Parametreleri Üzerine Etkisi
Authors: ÖLMEZ Mükremin , KARA Kanber , KARADAĞOĞLU Özlem , ÖĞÜN Metin , ŞAHİN Tarkan , ŞERBETÇİ İdil
Published: May 2022

Chia (Salvia hispanica L.), Labiate ailesinin bir üyesidir ve tohumları, çiftlik hayvanlarının performansını ve üretkenliğini artırabilecek fenolik bileşikler ve çoklu doymamış yağ asitleri (PUFA'lar) bakımından zengin, antioksidan özelliğindedir. Probiyotikler ise hayvan sağlığı ve büyüme performansı üzerinde farmasötik ve/veya metabolik etkilere sahip olabilecek yem katkı maddeleridir. Etki tarzlarındaki farklılıklar nedeniyle, bunların kombinasyonları ruminant hayvanlarda performans, kan ve rumen parametreleri üzerinde ilave etkilere sahip olabilir. Bu amaçla, çalışmada Tuj koyunları (n=20; 1,5 yaşında; ortalama 40,5 kg) her birinde 5 hayvan bulunacak şekilde 1 kontrol ve 3 deneme grubuna ayrılmıştır. Çalışma rasyonlarına ayrı ve kombine olarak, sırası ile 0, %2,5 chia tohumu (CT), 1g/kg probiyotik enzim karışımı (P+E) ve %2,5 CT + 1g/kg P+E ilavesi yapılmıştır. Koyunlar 7 gün adaptasyon ve 14 gün deneme süresi olacak şekilde toplam 21 gün beslenmiştir. Sonuçlar göstermiştir ki, Tuj koyunlarının rasyonlarına CT ve/veya P+E ilavesinin besi performansı üzerine etkisinin önemsiz bulunmuştur (P>0,05). Rumen toplam uçucu yağ (tVFA) asitleri konsantrasyonu kontrol grubuna göre artarken (P0,05). Serum Esterleşmemiş yağ asitleri, Betahidroksibütrikasit, Nitrik oksit ve kalsiyum, değerleri katkı maddesi ilavesi yapılan deneme gruplarında kontrol grubuna göre farklılık gösterirken (P0,05).
KARAKTERISTIK DAN ANALISIS KEKERABATAN RAGAM SERTA PEMANFAATAN TANAMAN KELAPA (Cocos nucifera) OLEH MASYARAKAT DI DESA SUNGAI SORIK DAN DESA RAWANG OGUNG KECAMATAN KUANTAN HILIR SEBERANG KABUPATEN KUANTAN SINGINGI
Authors: Riono Yoyon , Marlina Marlina , Yusuf Elfi Yenny , Apriyanto Mulono , Novitasari Rifni , Mardesci Hermiza
Published: May 2022

Research on the characteristics and analysis of kinship diversity and the use of coconut (Cocos nucifera L.) in Sungai Sorik and Rawang Ogung villages has been carried out to find out there are several varieties, kinship relationships, and benefits of coconut (Cocos nucifera L.). Exploration of coconut (Cocos nucifera L.) was carried out in Sungai Sorik and Rawang Ogung Villages. Plant Development Structure, carried out February-July 2021. The research method used exploration and observation and measurements of plant parts to make a description of coconut (Cocos nucifera L.). The results of morphological and anatomical observations in the form of qualitative and quantitative data. The results showed that there were three varieties of coconut (Cocos nucifera L.) namely deep coconut (pelak/polak), early coconut (superior), and yellow coconut.

 

Penelitian tentang karakteristik dan analisis kekerabatan ragam serta pemanfaatan tanaman kelapa (Cocos nucifera L.) di Desa Sungai Sorik dan Rawang Ogung telah dilakukan untuk mengetahui ada beberapa ragam, hubungan kekerabatan dan manfaat tanaman kelapa (Cocos nucifera L.). Eksplorasi tanaman kelapa (Cocos nucifera L.) dilakukan di Desa Sungai Sorik dan Rawang Ogung Struktur Perkembangan Tumbuhan, dilaksanakan Februari-Juli 2021. Metode penelitian digunakan eksplorasi dan pengamatan  dan pengukuran bagian tanaman untuk  membuat deskripsi kelapa (Cocos nucifera L.). Hasil pengamatan morfologi dan anatomi berupa data kualitatif dan kuantitatif. Hasil penelitian didapatkan tiga ragam tanaman kelapa (Cocos nucifera L.) yaitu kelapo dalam (pelak/polak), kelapo genjah (unggul), kelapo kuning. Semua bagian tanaman kelapa memiliki manfaat ekonomi terutama buah kelapa dalam (pelak) memiliki daging buah paling tebal (1,7 cm) dan kelapo genjah (unggul) memiliki buah paling berat (2,6 kg).
PERAN COP26 SEBAGAI PENDUKUNG PENCAPAIAN TUJUAN 13 SDGS DI INDONESIA, DALAM PANDANGAN GREENPEANCE
Authors: Perbina Novika , Jeremie S Billy , FM Pasaribu Rueben
Published: May 2022

Lately, the issue of climate change is being discussed. Whether it's in social media or mass media. Not without reason, the issue of climate change is discussed, this is because there is not a single human being who is not affected by climate change. Starting from temperature changes, droughts, extreme weather, sea-level rise, and so on. Various ways have been taken to deal with this issue and one of them is the United Nations Conference on climate change (COP26). In this meeting, various agreements have been agreed such as measures to reduce the use of coal-fired electricity and others. This paper will discuss the relevance of COP26 to achieving the objectives of SDGs 13 in Indonesia.

 

Belakangan ini, isu perubahan iklim sedang gencar diperbincangkan. Entah itu dalam media sosial maupun media massa. Bukan tanpa alasan isu perubahan iklim ini diperbincangkan, hal ini dikarenakan tidak ada satu manusia yang tidak terkena dampak dari perubahan iklim. Mulai dari perubahan suhu, kekeringan, cuaca ekstrim, kenaikan permukaan air laut dan lain sebagainya. Berbagai cara telah dilakukan untuk menangani isu ini dan salah satunya adalah Konferensi PBB yang membahas tentang perubahan iklim (COP26). Dalam pertemuan ini, berbagai kesepakatan telah disepakati seperti langkah untuk mengurangi penggunaan listrik berbahan bakar batu bara dan lainnya. Tulisan ini akan membahas relevansi COP26 untuk tercapainya tujuan SDGS 13 di Indonesia.
PENGARUH PENAMBAHAN DAUN PANDAN WANGI PADA PENGOLAHAN VCO (VIRGIN COCONUT OIL) TERHADAP KESUKAAN KONSUMEN
Authors: Prianto Jeki , Novitasari Rifni , Apriyanto Mulono
Published: May 2022

This study aims to determine the effect of adding fragrant pandan leaves on VCO (Virgin Coconut Oil) processing on consumer preferences. This study used a completely randomized design method (CRD) with one factor, namely the concentration of addition of fragrant pandan leaf extract (P): (0%, 0.05%, 0.10%). Parameter analysis is the organoleptic test (color, taste, aroma, viscosity). The results showed that the concentration of addition of different fragrant pandan leaf extracts gave significantly different effects on the organoleptic test (color, taste, aroma, and viscosity). The results showed that the highest consumer preference assessment in the organoleptic test was found in the P2 treatment with a concentration of 0.20% addition of fragrant pandan leaf extract resulting in VCO which was liked by the community and was acceptable.

 

Abstrak

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan daun pandan wangi pada pengolahan VCO (Virgin Coconut Oil) terhadap kesukaan konsumen. Penelitian ini menggunakan metode rancangan Acak Lengkap (RAL) dengan satu faktor yakni konsentrasi penambahan ekstrak daun pandan wangi (P) : (0%, 0,05%, 0,10%). Parameter analisa adalah uji organoleptik (warna, rasa, aroma, kenentalan). Hasil penelitian menunjukkan bahwa konsentrasi penambahan ekstrak daun pandan wangi yang berbeda memberikan pengaruh yang berbeda nyata terhadap uji organoleptik (warna, rasa, aroma, dan kekentalan). Hasil penelitian menunjukkan bahwa penilaian kesukaan konsumen tertinggi pada uji organoleptik terdapat pada perlakuan P2 dengan konsentrasi penambahan ekstrak daun pandan wangi 0,20% menghasilkan VCO yang di sukai masyarakat dan dapat diterima.
Predicting the 2022 Australian Federal Election with Actuarial Methodologies
Authors: Kundu Sumedh , Madgwick Stuart
Published: May 2022

Election forecasting has, for a long time, been considered a major tool used by voters and politicians alike to understand the electoral mood. In Australia, tools such as opinion polling even drive many policy decisions made by governments. Yet, these same tools have been misleading and/or wrong in recent elections. The consequences of this have meant large fiscal loss for bookmakers, rash policy decisions, inappropriate leadership changes, and, recently, erosion of trust in the democratic process. Hence, we must look at new ways to analyse elections, and use a more appropriate system to mimic the actual voting system in the country where the election is being held. For example, in representative democracies with strong minor party representation like Australia, any forecasting method used must not use two-party preferred on a national basis, and, instead, analyse preference flows, and first preferences, for each seat. This study uses actuarial techniques to analyse probabilities of parties winning each of the 151 seats in the 2022 Election, and then calculates final party totals based on these probabilities.

 

This study aims to accurately predict the 2022 Election using a methodology which will enable a final forecast which is not misleading and is, in fact, appropriate for a representative democracy. Data used includes first preferences and Preference Flow data from the 2019 Election, Demographic data from the 2016 Census, Economic Data across 2019-22, and Opinion Polls from The Australian and Roy Morgan. Further, political insight will be used to discuss these results and the potential variances.
INFRARED SPECTRA OF THE FREE BASE OF PHTHALOCYANINE AND ITS DEUTERATED DERIVATIVES AND THEIR INTERPRETATION
Authors: Gladkov L. L. , Sokolov N. A. , Solovyov K. N.
Published: May 2022

The IR spectra of the free base of phthalocyanine and three of its deuterium derivatives have been studied experimentally and theoretically. Calculations of normal vibrations by the density functional theory method made it possible to carry out a detailed interpretation of the spectra and their changes upon isotope

substitution. Vibrations, frequencies of which are sensitive to the isotopic substitution of various positions of the molecule, have been established. A high delocalization of plane bending vibrations of NH bonds has been noted with the greatest change in vibration frequencies not exceeding 85 cm–1.
STRUCTURAL AND OPTICAL PROPERTIES OF SiC/Si HETEROSTRUCTURES OBTAINED USING RAPID VACCUM-THERMAL CARBIDIZATION OF SILICON
Authors: Lobanok M. V. , Mukhammad A. I. , Gaiduk P. I.
Published: May 2022

TEM investigation revealed that the rapid vacuum-thermal carbidization of silicon at 1100C leads to the formation of cubic silicon carbide (SiC) layers. The band of the IR transmission spectrum at 798 cm–1 corresponding to the stretching vibration of Si-C and the maximum of Raman spectrum at 793 cm–1 relating to transverse optical phonon mode of SiC confirm the formation of a layer of the cubic SiC politype. The absorption

band of Si-O-Si (1100 cm–1) was found using the IR-spectroscopy. The dependence of the transmission coefficient on the wavenumber was determined.
EPR STUDY OF ACCUMULATION AND TOXIC EFFECT OF IRON AND COPPER DURING THE DEVELOPMENT OF Solanum tuberosum L. in vitro
Authors: Khutsishvili S. S. , Perfileva A. I. , Nozhkina O. A. , Dyrkach A. Yu.
Published: May 2022

The migration and accumulation of iron and copper ions in the process of growing Solanum tuberosum L vial potatoes have been studied. The form and content of the metals in the tissues of potatoes grown under factorostatic conditions have been determined by elemental analysis and electron paramagnetic resonance (EPR) method. The toxic effect of the studied heavy metals has been expressed in terms of physical-chemical characteristics (change in the EPR signals and metal accumulation in plant organs) and biometric parameters with an increase in the content of metal salts in the nutrient medium. In addition, the EPR spectra showed a narrow singlet typical for stable semiquinone radicals.