bluuebunny/crossref_metadata_2025 huggingface dataset:
Database of literature derived cellular measurements from the murine basal ganglia
Authors: Bjerke Ingvild E. , Puchades Maja A. , Bjaalie Jan G. , Leergaard Trygve B.
Published: July 2020

Quantitative measurements and descriptive statistics of different cellular elements in the brain are typically published in journal articles as text, tables, and example figures, and represent an important basis for the creation of biologically constrained computational models, design of intervention studies, and comparison of subject groups. Such data can be challenging to extract from publications and difficult to normalise and compare across studies, and few studies have so far attempted to integrate quantitative information available in journal articles. We here present a database of quantitative information about cellular parameters in the frequently studied murine basal ganglia. The database holds a curated and normalised selection of currently available data collected from the literature and public repositories, providing the most comprehensive collection of quantitative neuroanatomical data from the basal ganglia to date. The database is shared as a downloadable resource from the EBRAINS Knowledge Graph (https://kg.ebrains.eu), together with a workflow that allows interested researchers to update and expand the database with data from future reports.
DiB-splits: nature-guided design of a novel fluorescent labeling split system
Authors: Bozhanova Nina G. , Gavrikov Alexey S. , Mishin Alexander S. , Meiler Jens
Published: July 2020

Fluorogen-activating proteins (FAPs) are innovative fluorescent probes combining advantages of genetically-encoded proteins such as green fluorescent protein and externally added fluorogens that allow for highly tunable and on demand fluorescent signaling. Previously, a panel of green- and red-emitting FAPs has been created from bacterial lipocalin Blc (named DiBs). Here we present a rational design as well as functional and structural characterization of the first self-assembling FAP split system, DiB-splits. This new system decreases the size of the FAP label to ~8–12 kDa while preserving DiBs’ unique properties: strong increase in fluorescence intensity of the chromophore upon binding, binding affinities to the chromophore in nanomolar to low micromolar range, and high photostability of the protein-ligand complex. These properties allow for use of DiB-splits for wide-field, confocal, and super-resolution fluorescence microscopy. DiB-splits also represent an attractive starting point for further design of a protein-protein interaction detection system as well as novel FAP-based sensors.
Atypical age-related changes in cortical thickness in autism spectrum disorder
Authors: Nunes Adonay S. , Vakorin Vasily A. , Kozhemiako Nataliia , Peatfield Nicholas , Ribary Urs , Doesburg Sam M.
Published: July 2020

Recent longitudinal neuroimaging and neurophysiological studies have shown that tracking relative age-related changes in neural signals, rather than a static snapshot of a neural measure, could offer higher sensitivity for discriminating typically developing (TD) individuals from those with autism spectrum disorder (ASD). It is not clear, however, which aspects of age-related changes (trajectories) would be optimal for identifying atypical brain development in ASD. Using a large cross-sectional data set (Autism Brain Imaging Data Exchange [ABIDE] repository; releases I and II), we aimed to explore age-related changes in cortical thickness (CT) in TD and ASD populations (age range 6–30 years old). Cortical thickness was estimated from T1-weighted MRI images at three scales of spatial coarseness (three parcellations with different numbers of regions of interest). For each parcellation, three polynomial models of age-related changes in CT were tested. Specifically, to characterize alterations in CT trajectories, we compared the linear slope, curvature, and aberrancy of CT trajectories across experimental groups, which was estimated using linear, quadratic, and cubic polynomial models, respectively. Also, we explored associations between age-related changes with ASD symptomatology quantified as the Autism Diagnostic Observation Schedule (ADOS) scores. While no overall group differences in cortical thickness were observed across the entire age range, ASD and TD populations were different in terms of age-related changes, which were located primarily in frontal and tempo-parietal areas. These atypical age-related changes were also associated with ADOS scores in the ASD group and used to predict ASD from TD development. These results indicate that the curvature is the most reliable feature for localizing brain areas developmentally atypical in ASD with a more pronounced effect with symptomatology and is the most sensitive in predicting ASD development.
The compositional homogeneity of the metal particle during vapor–liquid–solid growth of nanowires
Authors: Johansson Jonas , Overgaard Niels Chr. , Magnusson Martin H.
Published: July 2020

The vapor–liquid–solid (VLS) mechanism is probably the most versatile method to fabricate semiconductor nanowires and several investigations assume a compositionally homogeneous catalyst particle. In this investigation we address the compositional homogeneity of the catalyst particle during growth of nanowires. Using diffusion calculations, we show that the particle is indeed homogeneous during VLS growth, but can have a strong concentration gradient during vapor–solid–solid growth, that is, growth with a solid particle. We also show that the response to a concentration change is extremely fast, meaning that if the concentration at the surface of the particle changes, the entire particle reaches this new concentration effectively instantaneously.
Use of carbon coating on LiNi0.8Co0.1Mn0.1O2 cathode material for enhanced performances of lithium-ion batteries
Authors: Sim Seong-Ju , Lee Seung-Hwan , Jin Bong-Soo , Kim Hyun-Soo
Published: July 2020

Ni-rich cathode is one of the promising candidate for high-energy lithium-ion batteries. In this work, we prepare the different super-P carbon black amounts [0.1 (SPB 0.1 wt%), 0.3 (SPB 0.3 wt%), 0.5 (SPB 0.5 wt%) and 0.7 wt% (SPB 0.7 wt%)] of carbon coated LiNi0.8Co0.1Mn0.1O2 (NCM811) cathodes and their electrochemical performances are investigated. Carbon coating does not change the crystal structure and morphology of NCM811. Among the coated NCM811, the SPB 0.5 wt% NCM811 delivers the excellent cyclability (87.8% after 80 cycles) and rate capability (86.5% at 2 C) compared to those of pristine NCM811. It is ascribed to that the carbon coating not only increase the Li ion and electron transfer as well as protect the NCM811 cathode materials from side reaction at the electrolyte/NCM811 interface. Therefore, we can conclude that the appropriate amount of carbon coating can be regarded as an effective approach for Ni-rich NCM cathode.
Investigating the influence of mtDNA and nuclear encoded mitochondrial variants on high intensity interval training outcomes
Authors: Harvey N. R. , Voisin S. , Lea R. A. , Yan X. , Benton M. C. , Papadimitriou I. D. , Jacques M. , Haupt L. M. , Ashton K. J. , Eynon N. , Griffiths L. R.
Published: July 2020

Mitochondria supply intracellular energy requirements during exercise. Specific mitochondrial haplogroups and mitochondrial genetic variants have been associated with athletic performance, and exercise responses. However, these associations were discovered using underpowered, candidate gene approaches, and consequently have not been replicated. Here, we used whole-mitochondrial genome sequencing, in conjunction with high-throughput genotyping arrays, to discover novel genetic variants associated with exercise responses in the Gene SMART (Skeletal Muscle Adaptive Response to Training) cohort (n = 62 completed). We performed a Principal Component Analysis of cohort aerobic fitness measures to build composite traits and test for variants associated with exercise outcomes. None of the mitochondrial genetic variants but eight nuclear encoded variants in seven separate genes were found to be associated with exercise responses (FDR < 0.05) (rs11061368: DIABLO, rs113400963: FAM185A, rs6062129 and rs6121949: MTG2, rs7231304: AFG3L2, rs2041840: NDUFAF7, rs7085433: TIMM23, rs1063271: SPTLC2). Additionally, we outline potential mechanisms by which these variants may be contributing to exercise phenotypes. Our data suggest novel nuclear-encoded SNPs and mitochondrial pathways associated with exercise response phenotypes. Future studies should focus on validating these variants across different cohorts and ethnicities.
Fabry–Pérot modes associated with hyperbolic-like dispersion in dielectric photonic crystals and demonstration of a bending angle sensor at microwave frequencies
Authors: Darthy R. Rachel , Venkateswaran C. , Subramanian V. , Ouyang Zhengbiao , Yogesh N.
Published: July 2020

The dispersion properties of metamaterials and photonic crystals (PhCs) lead to an intensive research in the development of cavity resonators for the confinement of electromagnetic (e-m) radiation. In this work, we investigate the formation of Fabry–Pérot (FP) modes associated with hyperbolic-like dispersion (HLD) regimes in two-dimensional dielectric PhCs. Conventionally, FP modes are formed using an optical etalon, in which electromagnetic (e-m) waves reflecting from a partially reflecting mirror separated by a distance can interfere constructively and form a resonating mode. The FP mode observed in dielectric PhCs is formed due to the interference of cylindrical wavefronts inside the PhC interface at HLD frequencies. The FP modes in PhCs are surface localized, in which maxima/minima of the electric field lies along the air–PhC interface as a standing wave pattern and decays in air medium. Projected bandstructure, Eigen Frequency Contours (EFC), phase and group index calculations are carried out to explain the formation of FP modes in PhCs under different coupling cases. By varying the PhC dimension, FP modes with different spatial profiles are witnessed and the role of source position in exciting specific mode is demonstrated. The observed FP modes in PhCs are compared with the FP mode in an ideal indefinite slab. Based on the FP resonance in PhCs, a sensing device capable of detecting a bending angle less than $$0.05^\circ$$0.05∘ is demonstrated numerically. The FP modes in PhCs are scalable to other parts of e-m spectra so that the bending angle sensing can be extendable to terahertz and optical domains.
The dynamic evolution of mobile open reading frames in plastomes of Hymenophyllum Sm. and new insight on Hymenophyllum coreanum Nakai
Authors: Kim Hyoung Tae , Kim Jung Sung
Published: July 2020

In this study, four plastomes of Hymenophyllum, distributed in the Korean peninsula, were newly sequenced and phylogenomic analysis was conducted to reveal (1) the evolutionary history of plastomes of early-diverging fern species at the species level, (2) the importance of mobile open reading frames in the genus, and (3) plastome sequence divergence providing support for H. coreanum to be recognized as an independent species distinct from H. polyanthos. In addition, 1C-values of H. polyanthos and H. coreanum were measured to compare the genome size of both species and to confirm the diversification between them. The rrn16-trnV intergenic regions in the genus varied in length caused by Mobile Open Reading Frames in Fern Organelles (MORFFO). We investigated enlarged noncoding regions containing MORFFO throughout the fern plastomes and found that they were strongly associated with tRNA genes or palindromic elements. Sequence identity between plastomes of H. polyanthos and H. coreanum is quite low at 93.35% in the whole sequence and 98.13% even if the variation in trnV-rrn16 intergenic spacer was ignored. In addition, different genome sizes were found for these species based on the 1C-value. Consequently, there is no reason to consider them as a conspecies.
Chemical modification of lignin derived from spent coffee grounds for methylene blue adsorption
Authors: Taleb Fayrouz , Ammar Mohamed , Mosbah Mongi ben , Salem Ridha ben , Moussaoui Younes
Published: July 2020

In this work, spent coffee grounds (SCG) were treated using sulfuric acid hydrolysis in order to isolate the sulfuric acid lignin (SAL). The reactivity of SAL was improved through phenolation and acetylation. Spectroscopic analysis showed that the isolated lignin is composed of GHS type and it was characterized by a high amount of (C–C) and β-O-4 bonds. The thermal analysis showed that the phenolated sulfuric acid lignin (Ph-SAL) present higher thermal stability compared to SAL and acetylated sulfuric acid lignin. In addition, the phenolic hydroxyl group content increases from 2.99 to 9.49 mmol/g after phenolation. Moreover, a methylene blue (MB) adsorption test was established in order to find out the sorption capacity of different samples. The study showed that the adsorbed amount of dye increase after the chemical modification of SAL, especially after phenolation. The removal efficiency was enhanced after modification to reach 99.62% for Ph-SAL. The evaluation of the adsorption experimental data with the theoretical models of Langmuir and Freundlich showed that the best fitting was expressed by the Langmuir model for all samples. Finally, this study showed that lignin isolated from SCG can be simply and easily chemical modified and exhibits excellent adsorption ability towards cationic dyes (MB) in aqueous solutions. As a renewable, low-cost, and natural biomass material, lignin from SCG shows a promising practical and economical application of biomass in the field of wastewater purification.
Taphonomy and chronosequence of the 709 ka Kalinga site formation (Luzon Island, Philippines)
Authors: Ingicco T. , Reyes M. C. , de Vos J. , Belarmino M. , Albers P. C. H. , Lipardo I. , Gallet X. , Amano N. , van den Bergh G. D. , Cosalan A. D. , Bautista A.
Published: July 2020

The recently described site of Kalinga in the Philippines adds to our understanding of Early-Middle Pleistocene hominin behaviour. Yet, disentangling the natural from the anthropogenic modifications that have taken place in such an old archaeological site is challenging. In this paper we use a set of taphonomic tools at hand to rectify the distortion made by natural processes during the formation of the Kalinga site. From the description of the ribs completeness, surface damages and scattering in the excavation, one can reconstruct the butchery, transport and deposition sequence of the rhino carcass and its post-depositional disturbances and diagenetic evolution of the site. We conclude that the rhino and the stone artefacts potentially used to deflesh the carcass were transported by a mudflow from its butchery place over a few meters only and got stuck and mixed with an older faunal assemblage that was transported by a small stream.
Singlemoded THz guidance in bendable TOPAS suspended-core fiber directly drawn from a 3D printer
Authors: Talataisong Wanvisa , Gorecki Jon , Ismaeel Rand , Beresna Martynas , Schwendemann Daniel , Apostolopoulos Vasilis , Brambilla Gilberto
Published: July 2020

Terahertz (THz) technology has witnessed a significant growth in a wide range of applications, including spectroscopy, bio-medical sensing, astronomical and space detection, THz tomography, and non-invasive imaging. Current THz microstructured fibers show a complex fabrication process and their flexibility is severely restricted by the relatively large cross-sections, which turn them into rigid rods. In this paper, we demonstrate a simple and novel method to fabricate low-cost THz microstructured fibers. A cyclic olefin copolymer (TOPAS) suspended-core fiber guiding in the THz is extruded from a structured 3D printer nozzle and directly drawn in a single step process. Spectrograms of broadband THz pulses propagated through different lengths of fiber clearly indicate guidance in the fiber core. Cladding mode stripping allow for the identification of the single mode in the spectrograms and the determination of the average propagation loss (~ 0.11 dB/mm) in the 0.5–1 THz frequency range. This work points towards single step manufacturing of microstructured fibers using a wide variety of materials and geometries using a 3D printer platform.
The influence of age and gender on emu (Dromaius novaehollandiae) fat
Authors: Bucław Mateusz , Majewska Danuta , Szczerbińska Danuta , Ligocki Marek
Published: July 2020

Studies were carried out to determine the influence of age and sex on two types of fat (back fat and abdominal fat) in the emu, as these are factors that influence the composition of animal tissues. The material involved 26 emus at the age 1 (6 males), 3 (6 males) and 15 years (8 females and 6 males), kept on the same farm and fed the feed of the same nutritional value. The basic chemical composition, cholesterol and mineral content, as well as fatty acid profile of back and abdominal fat of emu were determined. Abdominal fat was characterized by higher content of fat and ash, as well as Mn and Ba. Back fat, on the other hand, showed a higher level of protein, cholesterol, C16:1 and the elements K, P, Si, Na, Ca, Mg, Fe, Zn, Se and Cu. With age, regardless of the type of fat tissue, fat content decreased and water content increased. The highest content of protein, ash, cholesterol, some fatty acids (C18:0, C18:1n9c, C18:2n6c), generally higher content of MUFA, PUFA and the elements K, P, Ca, Mg, Fe, Zn, Pb, Se, Cr, Cd, were found in the fatty tissue of 15-year-old emus. Sex did influence the content of Si, Ca, Cu, Sr, which was higher in the fatty tissue of males. The composition of emu storage fat is determined by factors such as age, sex and the location of the fat tissue in the body.
Biological control agent attack timing and population variability, but not density, best explain target weed density across an environmental gradient
Authors: Harms Nathan , Cronin James
Published: July 2020

Spatial variation in plant–herbivore interactions can be important in pest systems, particularly when insect herbivores are used as biological control agents to manage invasive plants. The geographic ranges of the invasive plant alligatorweed (Alternanthera philoxeroides) and its biological control agent the alligatorweed flea beetle (Agasicles hygrophila) do not completely overlap in the southeastern USA, producing spatial heterogeneity in interaction strength that may be related to latitude-correlated environmental gradients. We studied this system near the range margin of the alligatorweed flea beetle to test whether spatial variation in alligatorweed density was best explained by agent mean or maximum density, variability in agent density, agent attack timing, or a combination of biological control and environmental (i.e., weather) variables. The pattern that emerged was that mean agent and host densities were negatively and positively associated with latitude, respectively. Variability in agent density increased with latitude and was positively correlated with host density. We further discovered that agent first attack timing was negatively correlated with winter and spring temperatures and spring and summer precipitation, and positively correlated with seasonal temperature extremes, which was then directly influential on agent density and variability in density, and indirectly on host density. This study demonstrates that, contrary to common wisdom, weather-related timing of agent activity and population variability, but not agent mean density, contribute to the spatial heterogeneity observed in alligatorweed populations.
Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms
Authors: Engel Daiane F. , Bobbo Vanessa C. D. , Solon Carina S. , Nogueira Guilherme A. , Moura-Assis Alexandre , Mendes Natalia F. , Zanesco Ariane M. , Papangelis Athanasios , Ulven Trond , Velloso Licio A.
Published: July 2020

Hypothalamic adult neurogenesis provides the basis for renewal of neurons involved in the regulation of whole-body energy status. In addition to hormones, cytokines and growth factors, components of the diet, particularly fatty acids, have been shown to stimulate hypothalamic neurogenesis; however, the mechanisms behind this action are unknown. Here, we hypothesized that GPR40 (FFAR1), the receptor for medium and long chain unsaturated fatty acids, could mediate at least part of the neurogenic activity in the hypothalamus. We show that a GPR40 ligand increased hypothalamic cell proliferation and survival in adult mice. In postnatal generated neurospheres, acting in synergy with brain-derived neurotrophic factor (BDNF) and interleukin 6, GPR40 activation increased the expression of doublecortin during the early differentiation phase and of the mature neuronal marker, microtubule-associated protein 2 (MAP2), during the late differentiation phase. In Neuro-2a proliferative cell-line GPR40 activation increased BDNF expression and p38 activation. The chemical inhibition of p38 abolished GPR40 effect in inducing neurogenesis markers in neurospheres, whereas BDNF immunoneutralization inhibited GPR40-induced cell proliferation in the hypothalamus of adult mice. Thus, GPR40 acts through p38 and BDNF to induce hypothalamic neurogenesis. This study provides mechanistic advance in the understating of how a fatty acid receptor regulates adult hypothalamic neurogenesis.
Laminin-511-E8 promotes efficient in vitro expansion of human limbal melanocytes
Authors: Polisetti Naresh , Gießl Andreas , Li Shen , Sorokin Lydia , Kruse Friedrich E. , Schlötzer-Schrehardt Ursula
Published: July 2020

Limbal melanocytes, located in the basal epithelial layer of the corneoscleral limbus, represent essential components of the corneal epithelial stem cell niche, but, due to difficulties in their isolation and cultivation, their biological roles and potential for stem cell-based tissue engineering approaches have not been comprehensively studied. Here, we established a protocol for the efficient isolation and cultivation of pure populations of human limbal melanocytes, which could be expanded at high yield by using recombinant laminin (LN)-511-E8 as culture substrate. Co-cultivation of limbal melanocytes with limbal epithelial stem/progenitor cells on fibrin hydrogels pre-incubated with LN-511-E8 resulted in multilayered stratified epithelial constructs within ten days. By reproducing physiological cell–cell and cell–matrix interactions of the native niche environment, these biomimetic co-culture systems provide a promising experimental model for investigating the functional roles of melanocytes in the limbal stem cell niche and their suitability for developing advanced epithelial grafts for ocular surface surface reconstruction.
Author Correction: Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer
Authors: Kim Min Soo , Jeong Joon , Seo Jeongbeob , Kim Hae-Suk , Kim Seong-Jin , Jin Wook
Published: July 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
The effect of Cu nanoparticle adding on to epoxy-based adhesive and adhesion properties
Authors: Necati Ataberk
Published: July 2020

Epoxy-based adhesives are widely used for repairing or jointing the metal sheets in the industry. Because of their superior mechanical properties, the metallic nanoparticles can be selected as the additive of the epoxy adhesive. The strength of the Cu nanoparticles (CuNPs) can be expected to improve the mechanical properties of neat epoxy. In this study, CuNPs were added at various weight ratios, such as 1, 2, 5, 10, 15, and 20% into the epoxy resin adhesive. Tensile tests of the dog-bone specimens and the lap-shear tensile tests of the single lap joints were performed for obtaining the mechanical properties. In order to investigate the failure mechanisms, the fractured surfaces of the tensile test samples and adhesively joined sheets were imaged by using a Scanning Electron Microscope. The thermal properties of the adhesives were obtained by using Thermo Gravimetric Analysis and Differential Thermal Analysis. The mechanical and thermal properties of epoxy resin adhesive were improved by adding the CuNPs. The best adding ratios of CuNPs into epoxy were obtained by both mechanical and thermally point of views. As a result of this study, 15 wt% the ratio of Cu nanoparticle adding into the epoxy-based adhesive is suitable for improving the mechanical properties. On the other hand, 20% is the proper Cu nanoparticle adding ratio for the thermal properties improving.
Author Correction: Linking soil microbial community dynamics to straw-carbon distribution in soil organic carbon
Authors: Su Yao , He Zhenchao , Yang Yanhua , Jia Shengqiang , Yu Man , Chen Xijing , Shen Alin
Published: July 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Genome-wide identification of Arabidopsis long noncoding RNAs in response to the blue light
Authors: Sun Zhenfei , Huang Kai , Han Zujing , Wang Pan , Fang Yuda
Published: July 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publisher Correction: Holistic Monte-Carlo optical modelling of biological imaging
Authors: Carles Guillem , Zammit Paul , Harvey Andrew R.
Published: July 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Changes in Reef Fish Community Structure Following the Deepwater Horizon Oil Spill
Authors: Lewis Justin P. , Tarnecki Joseph H. , Garner Steven B. , Chagaris David D. , Patterson William F.
Published: July 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Eriodictyol suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis
Authors: Yang Ting , Li Xing , Yu Jie , Deng Xin , Shen Pei-Xin , Jiang Yan-Bing , Zhu Lin , Wang Zhe-Zhi , Zhang Yuan
Published: July 2020

Eriodictyol (EDT), a natural flavonoid abundant in citrus fruits and peanuts, alleviates clinical signs of EAE by suppressing RORγt-Regulated Th17 cell differentiation.
A spot test for total esters determination in sugarcane spirits exploiting smartphone-based digital images
Authors: Soares Samara , Campos Karoline R. R. , Melchert Wanessa R. , Rocha Fábio R. P.
Published: July 2020

A novel approach for determining total esters in cachaça exploiting a spot test with smartphone-based digital image detection.
Prevascularized, multiple-layered cell sheets of direct cardiac reprogrammed cells for cardiac repair
Authors: Song Seuk Young , Kim Hyeok , Yoo Jin , Kwon Sung Pil , Park Bong Woo , Kim Jin-ju , Ban Kiwon , Char Kookheon , Park Hun-Jun , Kim Byung-Soo
Published: July 2020

We developed cardiac-reprogrammed cell sheets via cardiac-mimetic cell culture system with biodegradable PLGA membrane. The prevascularized, multiple-layered cell sheets prevented heart failure after myocardial infarction.
A high-power and long-life aqueous rechargeable Zn-ion battery based on hierarchically porous sodium vanadate
Authors: Qiu Nan , Yang Zhaoming , Wang Yuan , Zhu Yingming , Liu Wei
Published: July 2020

A high-power and long-life aqueous rechargeable Zn-ion battery with consequent capacitive- and diffusion-controlled mechanism.
Ultrafast, dry microwave superheating for the synthesis of an SbOx–GNP hybrid anode to investigate the Na-ion storage compatibility in ester and ether electrolytes
Authors: Ghosh Sourav , Qi Zhimin , Wang Haiyan , Martha Surendra K. , Pol Vilas G.
Published: July 2020

An SbOx–GNP hybrid anode is synthesised with the aid of ultrafast dry microwave superheating in 30 seconds.
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate
Authors: Zahorska Eva , Kuhaudomlarp Sakonwan , Minervini Saverio , Yousaf Sultaan , Lepsik Martin , Kinsinger Thorsten , Hirsch Anna K. H. , Imberty Anne , Titz Alexander
Published: July 2020

Design and four step synthesis of simple, readily accessible low-nanomolar divalent LecA ligands with selectivity over human galectin-1.
Guidelines for designing highly concentrated electrolytes for low temperature applications
Authors: Ah-lung Guillaume , Flamme Benjamin , Ghamouss Fouad , Maréchal Manuel , Jacquemin Johan
Published: July 2020

The WISS concept for the rational design of aqueous electrolytes for low temperature applications.
Interaction of carbon monoxide with doped metal clusters
Authors: Ferrari Piero , Libeert Guillaume , Tam Nguyen Minh , Janssens Ewald
Published: July 2020

Highlight of experimental and computational studies about the interaction of CO with transition and coinage metal clusters, particularly discussing the influence of dopant atoms.
Growth of dispersed hydroxyapatite crystals highly intertwined with TEMPO-oxidized cellulose nanofiber
Authors: Yamada Tetsuya , Kitamura Takeo , Morita Yuko , Mizuno Masahiro , Yubuta Kunio , Teshima Katsuya
Published: July 2020

Hydroxyapatite was grown with TEMPO-oxidized cellulose nanofiber as gel template, providing a highly intertwined, dispersed crystalline composite among the fibers.
Tuning oxygen vacancy and growth step for the high performance of Nd1+xBa2−xCu3Oy bulk cryomagnets
Authors: Huang Simin , Zhuang Yufeng , Zhu Yanhan , Yin Yiqian , Wan Yan , Zhou Difan , Chaud Xavier , Zhou Ligang , Yao Xin
Published: July 2020

The Nd1+xBa2−xCu3Oy superconductor is considered to be one of the most promising materials in the REBaCu3Oy family owing to its excellent properties of high critical transition temperature (Tc) and high current density.
Melt-grown large-sized Cs2TeI6 crystals for X-ray detection
Authors: Xiao Bao , Wang Fangbao , Xu Meng , Liu Xin , Sun Qihao , Zhang Bin-Bin , Jie Wanqi , Sellin Paul , Xu Yadong
Published: July 2020

Large-sized lead-free perovskite Cs2TeI6 shows an X-ray sensitivity of 27.8 μC Gy−1 cm−2 with a detection limit as low as 72.5 nGy s−1.
Employing rhodium tripod stars for ultraviolet plasmon enhanced Fabry–Perot mode lasing
Authors: Miao Changzong , Xu Haiying , Jiang Mingming , Ji Jiaolong , Kan Caixia
Published: July 2020

Rhodium tripod stars serving as ultraviolet plasmons can provide a highly competitive platform to achieve high-performance Fabry–Perot lasing of quadrilateral ZnO microwires.
Calculations of quantum tunnelling rates for muonium reactions with methane, ethane and propane
Authors: Laude Gabriel , Calderini Danilo , Welsch Ralph , Richardson Jeremy O.
Published: July 2020

We evaluate quantum tunnelling rates for muonium reactions with various alkanes through a combination of instanton theory and machine-learning approaches.
Structural predictions of thiolate-protected gold nanoclusters via the redistribution of Au–S “staple” motifs on known cores
Authors: Lin Dongdong , Zheng Mengke , Xu Wen Wu
Published: July 2020

Four structures of gold nanoclusters were predicted via the redistribution of Au–S motifs on known cores.
Study of persistent luminescence and thermoluminescence in SrSi2N2O2:Eu2+,M3+(M = Ce, Dy, and Nd)
Authors: Majewska Natalia , Leśniewski Tadeusz , Mahlik Sebastian , Grinberg Marek , Chruścińska Alicja , Michalik Daniel , Sopicka-Lizer Małgorzata
Published: July 2020

The process of persistent luminescence, the delayed emission of light of irradiated substances, has long fascinated researchers, who have made efforts to explain the underlying physical phenomenon as well as put it to practical use.
Finding the optimal exchange–correlation functional to describe the excited state properties of push–pull organic dyes designed for thermally activated delayed fluorescence
Authors: Cardeynaels Tom , Paredis Simon , Deckers Jasper , Brebels Sonny , Vanderzande Dirk , Maes Wouter , Champagne Benoît
Published: July 2020

In view of designing organic dyes for TADF, TD-DFT calculations are performed on 10 prototypical donor-acceptor compounds and are benchmarked against riCC2 calculations, demonstrating that modified range-separated hybrids perform best.
Theoretical investigation of amino-acid adsorption on hydroxylated quartz surfaces: dispersion can determine enantioselectivity
Authors: Price Alastair J. , Johnson Erin R.
Published: July 2020

Differences in London dispersion, the weakest intermolecular interaction, can be sufficient to impart enantioselectivity for amino-acid adsorption on quartz.
Simultaneous manipulation of ion doping and cocatalyst loading into Mn0.3Cd0.7S nanorods toward significantly improved H2evolution
Authors: Han Yanling , Dong Xinfa
Published: July 2020

Ni2P and Ni2+jointly modified Mn0.3Cd0.7S photocatalysts were successfully fabricatedviaa facile solvothermal method. The loading of Ni2P and the doping of Ni2+proceeded simultaneouslyviaa one-step process.
Stabilization of a nanoporous NiCu dilute alloy catalyst for non-oxidative ethanol dehydrogenation
Authors: Janvelyan Nare , van Spronsen Matthijs A. , Wu Cheng Hao , Qi Zhen , Montemore Matthew M. , Shan Junjun , Zakharov Dmitri N. , Xu Fang , Boscoboinik J. Anibal , Salmeron Miquel B. , Stach Eric A. , Flyztani-Stephanopoulos Maria , Biener Juergen , Friend Cynthia M.
Published: July 2020

In situ and ex situ X-ray photoelectron spectroscopy and electron-microscopy reveal that the stability of nanoporous NiCu alloy catalysts for non-oxidative ethanol dehydrogenation improves by generating kinetically trapped Ni2+ subsurface states.
Acidic nanomaterials (TiO2, ZrO2, and Al2O3) are coke storage components that reduce the deactivation of the Pt–Sn/γ-Al2O3 catalyst in propane dehydrogenation
Authors: Guntida Adisak , Wannakao Sippakorn , Praserthdam Piyasan , Panpranot Joongjai
Published: July 2020

Pt–Sn/γ-Al2O3 catalysts were physically mixed with various nanostructured metal oxides (TiO2, ZrO2, and Al2O3) and investigated as catalysts for propane dehydrogenation at 550 °C and atmospheric pressure.
Energy transfer in supramolecular [Crypt-RE]-[W6I14] solids
Authors: Hummel Thorsten , Leis Wolfgang , Eckhardt Aaron , Ströbele Markus , Enseling David , Jüstel Thomas , Meyer Hans-Jürgen
Published: July 2020

Photophysical properties of tungsten iodides with the [W6I14]2− cluster core have been described with respect to phosphorescence and phosphorescence quenching by molecular oxygen.
The ecological half-life of radiocesium in surficial bottom sediments of five ponds in Fukushima based on in situ measurements with plastic scintillation fibers
Authors: Katengeza Estiner Walusungu , Sanada Yukihisa , Yoshimura Kazuya , Ochi Kotaro , Iimoto Takeshi
Published: July 2020

Ecological half-life (Teco) of 137Cs concentration over wide pond areas of surface sediments was evaluated from in situ monitoring with plastic scintillation fibers (PSF) between 2013 and 2019.
Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway
Authors: Castejón M. L. , Montoya T. , Alarcón-de-la-Lastra C. , González-Benjumea A. , Vázquez-Román M. V. , Sánchez-Hidalgo M.
Published: July 2020

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease without an effective and safe treatment.
Anti-stress effects of polyphenols: animal models and human trials
Authors: Sakakibara Hiroyuki , Shimoi Kayoko
Published: July 2020

Relationship between “stressors” and “stress responses”, such as hormone secretion. Some polyphenols can prevent stress responses, which subsequently prevent stress-related health problems.
Biomimetic construction of peritoneum to imitate peritoneal metastasis using digital micromirror device-based optical projection lithography
Authors: Ge Zhixing , Zhao Junhua , Yu Haibo , Yang Wenguang , Zhou Peilin , Wang Zhenning , Liu Lianqing
Published: July 2020

We simulated the peritoneum for composition, internal microstructure, surface topography and mechanical property, and reproduced the process of peritoneal metastasis.
CK2 inhibition, lipophilicity and anticancer activity of new N1versus N2-substituted tetrabromobenzotriazole regioisomers
Authors: El-Kardocy Ahmed , Mostafa Yaser A. , Mohamed Noha G. , Abo-Zeid Mohammad Nabil , Hassan Nivin A. , Hetta Helal F. , Abdel-Aal Abu-Baker M.
Published: July 2020

Both the type and position of polar group substitutions in polybrominated benzotriazoles dramatically change their lipophilicity, kinase inhibition and anticancer activity.
Copper-catalyzed cross-coupling of vinyliodonium salts and diboron reagents to generate alkenyl boronic esters
Authors: Zhu Dan , Gan Shaoyan , Bao Robert Li-Yuan , Shi Lei
Published: July 2020

An efficient approach for the synthesis of alkenyl boronic esters through the copper-catalyzed cross-coupling of vinyliodonium salts and diboron reagents is reported.
All poly(ionic liquid) block copolymer nanoparticles from antagonistic isomeric macromolecular blocks via aqueous RAFT polymerization-induced self-assembly
Authors: Depoorter Jérémy , Yan Xibo , Zhang Biao , Sudre Guillaume , Charlot Aurélia , Fleury Etienne , Bernard Julien
Published: July 2020

All-poly(ionic liquid) block copolymer nanoparticles are prepared by aqueous RAFT PISA using a couple of isomeric ionic liquid monomers leading to macromolecular building blocks with antagonistic solution behavior in water.
Novel huperzine A based NMDA antagonists: insights from molecular docking, ADME/T and molecular dynamics simulation studies
Authors: Sigalapalli Dilep Kumar , Rangaswamy Raghu , Tangellamudi Neelima D.
Published: July 2020

The in silico study explores the structural behavior and binding affinities of 40 novel analogues of huperzine A. Novel NMDA receptor antagonists have been virtually identified by molecular docking, ADME/T and molecular dynamics simulation studies.
A decoupler-free simple paper microchip capillary electrophoresis device for simultaneous detection of dopamine, epinephrine and serotonin
Authors: Roychoudhury Appan , Francis Kevin Antony , Patel Jay , Jha Sandeep Kumar , Basu Suddhasatwa
Published: July 2020

This paper demonstrates a simplified configuration for capillary electrophoresis-amperometric detection using paper microfluidic chip for separation and simultaneous detection of three clinically relevant neurochemicals without using any decouplers.
High-performance aqueous sodium-ion battery using a hybrid electrolyte with a wide electrochemical stability window
Authors: Shen Yanxin , Han Xiaonan , Cai Tonghui , Hu Haoyu , Li Yanpeng , Zhao Lianming , Hu Han , Xue Qingzhong , Zhao Yi , Zhou Jin , Gao Xiuli , Xing Wei , Wang Xiaoning
Published: July 2020

The practical application of aqueous sodium-ion batteries (ASIBs) is limited by the electrolysis of water, which results in a low working voltage and energy density of ASIBs.
Cyclic metal(oid) clusters control platinum-catalysed hydrosilylation reactions: from soluble to zeolite and MOF catalysts
Authors: Rivero-Crespo Miguel , Oliver-Meseguer Judit , Kapłońska Klaudia , Kuśtrowski Piotr , Pardo Emilio , Cerón-Carrasco José Pedro , Leyva-Pérez Antonio
Published: July 2020

Metal(oid) association facilitates hydrosilylation intermediates compared to the accepted highly-strained Chalk–Harrod mechanism and enables solid catalyst design.
Redox-controlled chalcogen-bonding at tellurium: impact on Lewis acidity and chloride anion transport properties
Authors: Zhou Benyu , Gabbaï François P.
Published: July 2020

The oxidative alkylation of diorganotellurides enhances the chalcogen-bond donor properties of the tellurium center, an effect manifested in the enhanced chloride anion affinity and transport properties of the resulting telluronium cations.
Polymorph exploration of bismuth stannate using first-principles phonon mode mapping
Authors: Rahim Warda , Skelton Jonathan M. , Savory Christopher N. , Evans Ivana R. , Evans John S. O. , Walsh Aron , Scanlon David O.
Published: July 2020

Using a phonon mode-mapping approach, we recover the known experimental phases of the ternary oxide Bi2Sn2O7 and identify three new metastable phases, highlighting the utility of the method for polymorph prediction on many other complex materials.
Prediction of crossover in the molecular weight dependence of polyethylene viscosity using a polymer free volume theory
Authors: Wong Chi Pui Jeremy , Choi Phillip
Published: July 2020

Crossovers in the molecular weight dependence of viscosity for polyethylene with different structures are captured by a free volume theory.
Co-assembly of functionalized donor–acceptor molecules within block copolymer microdomains via the supramolecular assembly approach with an improved charge carrier mobility
Authors: Deepthi Krishnan , R B Amal Raj , Prasad Vadakkethonippurathu Sivankuttynair , Gowd E. Bhoje
Published: July 2020

Here, we demonstrate the three-component self-assembly of functionalized small molecules (donor and acceptor) and a polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) block copolymer using the supramolecular approach.
Dynamics and clogging of colloidal monolayers magnetically driven through a heterogeneous landscape
Authors: Leyva Sergi Granados , Stoop Ralph Lukas , Tierno Pietro , Pagonabarraga Ignacio
Published: July 2020

We combine experiments and numerical simulations to investigate the emergence of clogging in a system of interacting paramagnetic colloidal particles driven against a disordered landscape of larger obstacles.
Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels
Authors: Wang Yan , Zhang Wensi , Gong Coucong , Liu Bin , Li Yiduo , Wang Luchen , Su Zhiqiang , Wei Gang
Published: July 2020

The structural and functional tailoring of peptide hydrogels promotes their bio-related applications.
Self-assembly of an alkynylpyrene derivative for multi-responsive fluorescence behavior and photoswitching performance
Authors: Xia Cong-Xin , Wang Ning , Sun Pan-Pan , Tang Shao-Xiong , Xu Xing-Dong , Tan Ye-Bang , Xin Xia
Published: July 2020

Upon visible light irradiation, photoswitchable performance of nanovesicles was observed in which the emission markedly changed from yellow to blue.
Enabling electrochemical N2 reduction to NH3 in the low overpotential region using non-noble metal Bi electrodes via surface composition modification
Authors: Jang Youn Jeong , Choi Kyoung-Shin
Published: July 2020

Surface modification strategies that promote electrochemical N2 reduction on non-noble Bi electrodes in the low overpotential region are developed.
A novel self-assembly approach for synthesizing nanofiber aerogel supported platinum single atoms
Authors: Zhang Haojie , Zhao Yonghui , Sun Yu , Xu Qing , Yang Ruoou , Zhang Hao , Lin Chao , Kato Kenichi , Li Xiaopeng , Yamauchi Miho , Jiang Zheng
Published: July 2020

A new self-assembling methodology of incorporating Pt single atoms into metal oxide nanofiber is presented with controlled structural formation over the entire range of length scales. The Pt single atoms substantially enhance the oxygen reduction reaction performance.
Rational design of metal–ligands for the conversion of CH4 and CO2 to acetates: role of acids and Lewis acids
Authors: Bhaskararao Bangaru , Kim Dong Yeon , Madridejos Jenica Marie L. , Park Cheol-Min , Kim Kwang S.
Published: July 2020

Bifunctional Noyori-type complexes designed computationally for carboxylation reaction using CH4 and CO2 with additives show overall barriers of 20–27 kcal mol−1.
Recent advances in electrospun nanofibers for supercapacitors
Authors: Liang Jie , Zhao Haitao , Yue Luchao , Fan Guangyin , Li Tingshuai , Lu Siyu , Chen Guang , Gao Shuyan , Asiri Abdullah M. , Sun Xuping
Published: July 2020

We summarize latest advances of electrospun nanofibers as supercapacitor electrode materials, providing an in-depth understanding of pore engineering, heteroatom doping, construction of carbon-based composites and metal oxides.
Plasma-enhanced cycling durability of a Mo2C decorated N-doped carbon nanofiber electrocatalyst for Li–O2 battery cathodes
Authors: Sun Zhihui , Li Bao , Feng Cheng , Cao Xuecheng , Zheng Xiangjun , Zeng Kai , Jin Chao , Wu Xuemei , Dai Dongmei , Yang Ruizhi
Published: July 2020

A traditionally unperceived approach, glow discharge plasma, is employed to modify the surface of Mo2C@NCF. The plasma breaks the MoOx passivation layer on Mo2C and promotes the formation of interfacial Mo–N, leading to enhanced cycling durability.
A novel molybdenum oxide–Starbon catalyst for wastewater remediation
Authors: Kaur Jaspreet , Kaur Khushwinder , Mehta Surinder K. , Matharu Avtar S.
Published: July 2020

A highly efficient molybdenum–Starbon composite for catalytic reduction of 4-nitrophenol to 4-aminophenol for potential application in wastewater treatment.
Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish
Authors: Zhong Xiuli , Yang Qing , Chen Yingshuang , Jiang Yuliang , Dai Zhihui
Published: July 2020

Herein, two AIE probes (BTD-1 and BTD-2) were designed and synthesized based on benzothiazole derivatives which could be used to track and image trace hypochlorite in mitochondria of Hela cell and zebrafish.
Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats
Authors: Wang Yefang , Zhao Bo , Fei Yuxiang , Yin Qiyang , Zhu Jianping , Ren Guanghui , Wang Bowen , Fang Weirong , Li Yunman
Published: July 2020

The present study was designed to investigate the anti-apoptosis effect of Ma xing shi gan decoction (MXD) on PM2.5-induced lung injury via protein kinase B (Akt)/mTOR/p70S6K pathway. A UPLC-MS/MS system was introduced for component analysis of MXD. Rats were instilled with PM2.5 solution suspension intratracheally to induce acute lung injury. The rats were then orally administered with MXD (16, 8, and 4 g/kg) once a day for 7 consecutive days. The therapeutic effects of MXD were evaluated by Hematoxylin and Eosin (HE) staining. The apoptotic cell death was analyzed by terminal-deoxynucleotidyl transferase-mediated nick-end labeling (TUNEL) assay. The alterations in cytochrome c (Cytc) and cleaved-caspase-3 (C-caspase-3) were measured by immunohistochemistry (IHC). The expressions of Bax, B-cell lymphoma 2 (Bcl-2), p-Akt, p-mTOR and p-p70S6K were detected by Western blot. In vitro, PM2.5 exposure model was introduced in A549 cell, followed by incubation with MXD-medicated serum. Hoechst staining was used to determine apoptotic rate. The levels of Bax, Bcl-2, p-Akt, p-mTOR and p-p70S6K were detected by Western blot. Our results in vivo indicated that treatment with MXD decreased histopathological changes score, TUNEL-positive cells rate, expressions of Cytc and C-caspase-3. The in vitro results revealed that incubation with MXD-mediated serum decreased apoptotic rate. Both results in vivo and in vitro demonstrated that MXD inhibited pro-apoptotic protein Bax and promoted anti-apoptotic protein Bcl-2 expression. Likewise, MXD activated Akt/mTOR/p70S6K signal pathway, which was also confirmed by Western immunoblotting. In conclusion, MXD attenuates lung injury and the underlying mechanisms may relate to regulating the apoptosis via Akt/mTOR/p70S6K signaling pathway activation.