bluuebunny/crossref_metadata_2025 huggingface dataset:
The crystal structure of strictic acid, C20H26O3
Authors: Li Yijv , Zhao Nengwu , Ye Jianghai , Xu Fangfang , Li Tiantian , Lang Tianqiong
Published: January 2023

C20H26O3, orthorhombic, P21212 (no. 18), a = 10.0361(11) Å, b = 18.542(2) Å, c = 9.7357(12) Å, V = 1811.7(4) Å3, Z = 4, R

gt
(F) = 0.0535, wR

ref
(F
2) = 0.1553, T = 273(2) K.
Nonlinear computer image scene and target information extraction based on big data technology
Authors: Wang Jiaqi
Published: January 2023

To explore the extraction of computer image scene and target information, a nonlinear method based on big data technology is proposed. The method can decompose the computer image into a plurality of components when the SAR computer image is processed such as target extraction and computer image compression, which represent different captured image features, respectively. Selecting the most suitable processing method according to the characteristics of different components can greatly improve the performance. Using nonlinear diffusion method, the computer image is decomposed into structural components representing large-scale structural information and texture components representing small-scale detailed information, and the automatic threshold estimation in the diffusion process is studied. The LAIDA criterion is introduced into the automatic threshold solution of nonlinear diffusion-based computer image decomposition to test and evaluate the diffusion process of various diffusion parameter forms. The results show that the experimental outcome of the diffusion decomposition based on automatic threshold estimation is very close on each index, which shows that using automatic threshold estimation, no matter what diffusion index is used, very close results can be obtained. Specifically, for each algorithm, the parameter estimation threshold l for outliers plays an obvious role. The third is the degree of initiative of the estimation process. The larger the L, the larger the outlier, which will lead to a greater extent of the diffusion process, resulting in a continuous decrease in the structural similarity index and compositional correlation. It is proved that the algorithm has strong global search ability, can effectively avoid premature convergence, has fast convergence speed, and good long stability. It can be widely used for optimization of various multimodal functions.
Response surface methodology optimization and antimicrobial activity of berberine modified trimethoprim carboxymethyl cellulose
Authors: Fu Gui , Chen Zhenzhen , Qi Yingping , Li Hua
Published: January 2023

In order to solve the problem of bacterial resistance, increase the antibacterial performance and delay the aging of paper, the berberine modified trimethoprim carboxymethyl cellulose was prepared using trimethoprimethylate carboxymethyl cellulose as raw material and trimethoprimethylate lactate (TMP) as antibacterial modifier by Schiff Base reaction. At the same time, berberine (BBR) was used as graft monomer to prepare a multifunctional protective solution integrating strengthening, antibacterial and good biocompatibility. The optimal process conditions were determined by single factor experiment and response surface method. The structure and properties of the product were characterized by FT-IR, XRD, TG and SEM and the antibacterial properties were evaluated by AGAR disk diffusion method. The results showed that when the mass ratio of dialdehyde carboxymethyl cellulose and modified berberine was 7:15, reaction temperature was 40 °C, and pH was 6.0, the optimum synthetic conditions was obtained. And the minimum inhibitory concentration of the product against Staphylococcus aureus and Escherichia coli were 0.2 mg/mL, minimum diameter of antibacterial zone of 6.7 mm and 7.1 mm, respectively, with good antibacterial effect. This paper lays a foundation for further research on the safe and effective antiquities antibacterial agent, and provides a reference for its further development in paper protection.
Deep Learning Based Two-Dimensional Ultrasound for Follicle Monitoring in Infertility Patients
Authors: Liang Xiaowen , Zeng Fengyi , Li Haoming , Li Yuewei , Lin Yan , Cai Kuan , Ni Dong , Chen Zhiyi
Published: January 2023

Background: A two-dimensional (2D) ultrasound examination is the primary technique for follicle monitoring, but 2D ultrasound follicle monitoring has significant inter- and intra-observer variability in the measurement of follicle diameter. The aim of this study was to propose a novel deep learning-based automated model for accurate 2D ultrasound follicle monitoring and validate the reliability and repeatability in clinical practice.

Methods: A prospective trial including 300 infertile women undergoing ovulation induction (single follicle cycles) or controlled ovarian hyperstimulation (multiple follicle cycles) was conducted in the reproductive center. After 2D ultrasound image acquisition, the mean diameter of each targeted follicle was measured using an automated model, experts, and a novice. Designating the expert assessment as the gold standard, the reliability and repeatability of the automated model for single and multiple follicle cycles were evaluated using the intraclass correlation coefficient and Bland-Altman plots.

Results: A total of 228 and 1065 follicles from single and multiple follicle cycles, respectively, were included. The accurate recognition rate of follicle boundaries using the automated model was 0.931. The inter-observer variability of follicle mean diameter measurements in single and multiple follicle cycles were 0.970 and 0.984 for the automated model and experts, and 0.965 and 0.978 for a novice and experts, respectively. Bland-Altman plots showed that 95% limits of agreement for follicle diameter measurement between the automated model and experts (−2.02 to 2.39 mm and −0.68 to 1.50 mm) was lower than a novice and experts (−1.69 to 2.74 mm and −0.58 to 1.73 mm) for both single and multiple follicle cycles. The intraclass correlation (ICC) of follicle diameters ≥10 mm calculated by the automated model was significantly higher than follicle diameters <10 mm in multiple follicle cycles (0.834 vs. 0.609). There were no significant differences between the two groups in single follicle cycles (0.967 vs. 0.970).

Conclusion: A deep learning-based automated model provides an accurate and fast approach for novices to improve the reliability and receptivity of 2D ultrasound follicle monitoring, especially in multiple follicle cycles and for follicles with a mean diameter ≥ 10 mm.
Young Africa: art and diaspora. An experience at the University of Lleida
Authors:   Universidad de Lleida, Astudillo Marise , Revilla Alfonso , Llevot Nuria ,   Universidad de Lleida, Bernad Olga ,   Universidad de Lleida, Coffi Christian ,   Universidad de Nantes, Seck Papalaye
Published: January 2023

This article is the result of an inter-university, international and transdisciplinary experience carried out at the University of Lleida with the collaboration of the University of Zaragoza in the academic year 2021-2022, in which other groups and institutions also participated, on Young Africa: art and diaspora. Two seminars were held, a theoretical-practical one with students of the Degree in Social Education on the black-African artistic object as a reference of cultural pluralism and another international seminar with three papers on Art, resilience and rehumanisation, which dealt with music, dance and orality as a resilient therapy in African and Afrodiasporic traditions; an initiative on Top Manta, which is the brand of the commercial project of the Sindicato Mantero and, finally, a practical proposal to intervene from the artistic context in groups at risk, i.e. three proposals combined with an exhibition on Black African masks entitled "Learning to see the invisible".
Phenomenological review of the concept of empathy for Social Work
Authors:   Universidad de Barcelona, López José Antonio , Sangra Toni ,   Universidad de Barcelona, Iannitelli Silvia ,   Universidad de Barcelona
Published: January 2023

In the 21st century, social work faces the challenge to establish, using its own language, its object of knowledge. In this work, we delve into the concept of empathy by looking into contributions from the fields of Social Work, Aesthetics, Psychology, Psychoanalysis, Philosophy and the Neurosciences. The purpose of this article is to clarify the meaning assigned to the concept of empathy in Social Work. It is not possible to characterize this concept without evoking its phenomenological foundations. We consider possible attributions of the concept that could contribute to understand iatrogenic situations derived from professional praxis. For the elaboration of the proposal, we developed a critical analysis of the concept of empathy, related to that of intersubjectivity, by carrying out a bibliographic review based on the aforementioned disciplines, covering a period from 1909 to 2018. Lastly, the position of "cognitive empathy" is proposed as a strategy for understanding the intersubjective process.
The translator of Petri-object model visual programming language
Authors:   NTUU ", Dyfuchyn А.Yu. ,   KPI"
Published: January 2023

High-level programming tools are aimed at increasing the development speed of complex programs due to automation within the routine actions of the programmer, reducing the number of coding errors and reducing the code in general. Visual programming involves coding based on a visual representation of a task for the computational process instead of a textual one. The translator of the visual programming language of Petri-object models is designed and built according to the defi ned formal grammar of the language and Petri-object model formalism. It performs the transformation of the visual representation of the model into the calculation of the simulation algorithm. The advantages of the developed language are a small alphabet of symbols, the opportunity for replication of objects and connections between them, and the versatile application for the discrete-event systems models development.
Web service for enterprise resource manage- ment systems
Authors:   NTUU ", Tarasenko A.D. ,   KPI", Doroshenko A.Yu. ,   Institute of Software Systems NAS of Ukraine
Published: January 2023

A web service for enterprise resource management systems has been developed, which allows creating and managing fast secure enterprise resource management systems based on user-required modules. The uniqueness of the service is that in addition to the fact that it contains most of the existing standards and capabilities of other ERP systems from other IT companies, it has a significant advantage - there is no need to address IT-specialists for the development and configuration of ERP systems for the needs of the end user in its use. The main website of the web service has been developed, which provides authentication and authorization; installer application for creating and running ERP system; ERP server application, and client application for interaction with ERP system. Functional testing of the developed web service was carried out by testing each application separately and in a joint relationship. Thanks to the concept of modularity, this system is easily supplemented and expanded. In the future, this service can be supplemented with new functionality, depending on business requirements.
Biofilm formation, antibiotic resistance, and genome sequencing of a unique isolate Salmonella Typhimurium M3
Authors: Yuan Lei , Liu Yang , Chen Caowei , Yang Zhenquan , Jiao Xin-an
Published: January 2023

Salmonella Typhimurium is a zoonotic bacterium that can cause salmonellosis, and the major concerns of S. Typhimurium for the food industry are its ability to obtain multidrug resistance and form biofilms on food-contact surfaces. In the current study, the antimicrobial resistance of a strong biofilm former S. Typhimurium M3 was assessed by the diffusion method. Genome sequencing was also applied to obtain the genes related to antibiotic resistance, and biofilm formation of S. Typhimurium M3. Biofilm-forming capacity of S. Typhimurium M3 was found to be strain dependent, and a high number of isolates were strong biofilm formers. The high biofilm-forming isolate S. Typhimurium M3 was resistant to oxacillin, lincomycin, rifampicin, tetracycline, and clindamycin, with the MIC values of 512 μg/mL, 32 μg/mL, 16 μg/mL, 64 μg/mL, and 64 μg/mL, respectively. Genomic annotation of S. Typhimurium M3 showed the presence of genes involved in cellulose biosynthesis, curli production, fimbriae biosynthesis, flagellar assemble, quorum sensing, chemotaxis, and some transcriptional regulators. Antibiotic efflux conferring antibiotic resistance genes, antibiotic inactivation genes, and antibiotic target alteration genes were also identified. The results expand scientific understanding on how Salmonella isolates with high biofilm-forming capacity and multidrug resistance survive in stressful conditions in the industry.
X-Ray Computed Tomography for Failure Mechanism Characterisation within Layered Pouch Cells: Part II
Authors: Patel Drasti , Reid Hamish , Ball Sarah , Brett Dan J. L. , Shearing Paul R.
Published: January 2023

In Part I (), the failure response of a 1 Ah layered pouch cell with a commercially available nickel manganese cobalt (NMC) cathode and graphite anode at 100% state of charge (SOC) (4.2 V) was investigated for two failure mechanisms: thermal and mechanical. The architectural changes to the whole-cell and deformations of the electrode layers are analysed after failure for both mechanisms. A methodology for post-mortem cell disassembly and sample preparation is proposed and demonstrated to effectively analyse the changes to the electrode surfaces, bulk microstructures and particle morphologies. Furthermore, insights into critical architectural weak points in LIB pouch cells, electrode behaviours and particle cracking are provided using invasive and non-invasive X-ray computed tomography techniques. The findings in this work demonstrate methods by which LIB failure can be investigated and assessed.
Review: antibiotic residues in meat, a public health problem in Colombia
Authors: Jaimes-Dueñez Jeiczon , Ramírez-Villamizar Luis Horacio , Barragán-Díaz Ciro Alfonso , Cárdenas Enrique , Niño-Bayona José Vicente
Published: January 2023

La utilización de antibióticos en la producción animal ha representado grandes ventajas para los sistemas productivos, garantizando el control de enfermedades infecciosas que afectan la capacidad productiva de los animales, así como por su utilización como promotores de crecimiento. Por su parte, la presencia de residuos de estos fármacos en los alimentos de origen animal, especialmente en la carne, son considerados por los organismos mundiales para la seguridad e inocuidad de los alimentos como un factor de riesgo que puede afectar la salud pública, en especial los antibióticos, por la subsecuente resistencia que generan, además, de considerarse una barrera para el desarrollo económico de cualquier país por las limitaciones para expandirse a mercados internacionales. Los métodos para la detección de estos residuos son cada vez más sensibles, haciendo que para países como Colombia cobre especial importancia la reforma de las normativas, los mecanismos de control y el fortalecimiento de la capacidad tecnológica, dado el creciente interés por la exportación de la carne. Esta revisión pretende exponer los puntos más importantes de la presencia de estos residuos en la carne, incluyendo el panorama actual de la legislación nacional e internacional, así como resultados de investigaciones sobre los medicamentos más comunes que son encontrados, el efecto sobre la salud humana y los métodos más utilizados para su detección.
HATIRLAMA VE UNUTMA ARACI OLARAK BELLEK MEKÂNLARI
Authors: Sarıkaya Levent Yasemin
Published: January 2023

Korumanın nesnesi ve kapsamı Venedik Tüzüğü'nden günümüze daha kapsayıcı bir hal alarak genişlemiş. Nesne ve kapsam genişlerken, korumaya değer görülen nesneye atfedilen değerler setinin de değiştiği görülmektedir. Bu değerler seti, önceleri salt fiziksel ve tarihsel özelliklerden temel alırken, süreç içerisinde mekânın, yaşanmışlıklar ve sosyal olgular ile örüldüğü kabul edilmiş ve değerler seti, fiziksel özelliklerin yanı sıra sosyal özellikleri de içerir hale gelmiştir. Yeni anlayış çerçevesinde mekân, salt tarihi, bilimsel ve sanatsal değerinden ötürü değil, toplum tarafından kendisine atfedilen sembolik değerleri de içerisinde barındırmaktadır. Günümüzde kent belleğinin bir parçası haline gelen ve toplumun bir kısmında ortak hisler uyandıran, anıları canlandıran bellek mekânları, toplum tarafından atfedilen değerlerden ötürü güncel koruma tartışmaları içerisinde yer almaya başlamıştır.

Çalışmanın temel savı, mekânın birikimli bir şekilde toplumsal belleği sakladığı ve bir süre sonra bellek mekânına dönüştüğüdür. Çalışma, korumada değişen değerler anlayışı bağlamda bellek mekânlarının da kültürel miras öğesi olarak korunması gerektiğini ileri sürerek, bellek ve mekân ilişkisini anlamaya çalışmıştır. Çalışma kapsamında mekânın belleğinin nasıl oluştuğu ve bu birikimin nasıl bellek mekânlarına dönüştüğü incelenmiş; korumadaki yeni değerler seti bağlamında bellek mekânlarının neden önemli olduğuna ve neden korumanın nesnesi haline gelmesi gerektiğine değinilmiştir. Sonuç kısmında ise bellek mekânlarının korunması gerekliliği, unutma – unutturma pratikleri üzerinden tartışılmıştır.
TÜRKİYE-NATO İLİŞKİLERİNİN AHLAKİ ZEMİNİNİ KURMAK
Authors: Atatorun Mustafa
Published: January 2023

Bu çalışma, Türkiye’nin karşılaştığı askeri güvenlik tehditlerini NATO ilişkileri çerçevesinde ele alıp, ahlaki boyutta tartışmayı amaçlamaktadır. Tartışmanın ahlaki zeminini, egemen devletlerin ortak çıkarlar ve değerler etrafında bir araya gelerek toplum/topluluk oluşturabildiklerini iddia eden Uluslararası Toplum (İngiliz Okulu) kuramının çoğulcu etik yaklaşımı teşkil etmektedir. Ortak çıkar ve değerlerin devletler arası ilişkilere bir çeşit düzen ve istikrar getirdiğini savunan bu yaklaşım, devletlerin bir arada var olmasını, eşit egemenlik ve bağımsızlık haklarının karşılıklı tanınmasına bağlamaktadır. “Tanıma” olarak adlandırılan bu norm, burada hukuken tanıma şeklinde değil; pratik boyutunda egemenlik haklarına ve bağımsızlığa saygının gereklerini yerine getirme olarak alınmıştır. Her bir devletin çıkarına olan tanıma normuna bağlılık, barışçıl bir uluslararası ahlaki düzenin anahtarı görülmektedir. Makalede NATO, savunma ve güvenlik amacına/işlevine yönelik daha dar anlamda çoğulcu bir toplum/topluluk olarak; Türkiye’nin askeri güvenlik sorunları ise, ilişkileri belirleyen güçlü bir faktör olarak olarak ele alınmaktadır. Bu doğrultuda, Türkiye’nin askeri güvenlik sorunlarının yol açtığı önde gelen bazı NATO müttefikleriyle olan gergin ilişkilerde çoğulcu etiğin tanıma normunun yeri sorgulanmakta ve belli başlı NATO üyelerinin, Türkiye’ye askeri güvenlik tehdidi teşkil eden bir takım sorunlara yaklaşımlarında tanıma normuna aykırı tutum ve davranışlarda bulundukları öne sürülmektedir. Ayrıca çalışmada, NATO-Türkiye arasındaki ilişkilerin ahlaki zeminin üyelerin tanıma normuna riayetiyle mümkün olabileceği savunulmaktadır.
PLATON’UN AHLAK ANLAYIŞINDA RUH VE ERDEM İLİŞKİSİ
Authors: Bircan Ufuk
Published: January 2023

Bu makalede Platon’un idealist felsefesinde ahlakın tuttuğu yer ve erdemler ele alınmıştır. Ahlak felsefesi bağlamında Platon’un sistemi çerçevesinde ahlaki davranışın ilkelerinin neler olduğu ortaya konmaya çalışılmıştır. Platon’da ahlaki eylemin telosu/amacının mutluluk olduğu iddiası üzerinde durulmuştur. Mutluluk temelli olan ahlak anlayışının kaynağı, en iyi olana ulaşmaktır. Platon ahlak konusunu bilgi temelli incelediği için öncelikle epistemenin, doksadan ayrımı tartışma konusu edilmiştir. Daha sonra Platon’un Tanrı ve ahlak arasında kurduğu ilişki Euthyphron ikileminden hareketle incelenmiştir. Platon, ahlak düşüncesinde diğer alanlarda olduğu gibi hem ruhu bölümlere ayırır hem de her bir ruhun kemal sıfatına denk düşen erdemleri tanımlar. Çalışmanın her bir bölümünde Platon’un ahlak düşüncesinin bireysel ve toplumsal yönleri incelenmiş ve erdem çeşitleri ruhun bölümleri ile ilişkilendirilerek genel bir tablo resmedilmiştir. Bu çalışmanın amacı, kendinden sonra yapılan ahlak çalışmalarına temel teşkil eden Platon’un ahlak teorisinin, Platon’un ahlakla ilgili eserlerinden faydalanılarak düzenli bağlantılar çerçevesinde betimlenmesidir. Bu çalışmada Platon’un erdemlerin öğretilebilir bir şey olduğunu tartıştıktan sonra tekil olarak ele alınan bütün erdemlerin tek bir erdem halinde düşünülmesi gerektiği sonucuna varılmıştır.
TAXATION AND INCENTIVES IN RENEWABLE ENERGY INVESTMENTS
Authors: Kaplan Dönmez Nergis Feride
Published: January 2023

This research suggests that the under-one-roof taxation and incentives approach combined with a regularly adjusted subsidy may be the best course of action for learning by doing in renewable energy technology. In terms of financial investment, the study looks at how tax incentives and other forms of support for renewable energy sources are evaluated. The essential features of renewable energy sources are that they help to protect the environment, and renewable energy investments are a hot topic on the agendas of many countries. The Turkish energy market has been exposed to the liberalization process. So, the government, investors, and the people of the country are the main owners of these projects. Each partner directly or indirectly affects these investments or is involved in them. These things should be managed in a way that keeps the whole system in balance. This method turns the problem into a multi-objective optimization problem, with the goal of maximizing the benefits for all stakeholders. This research investigates the items related to renewable energy investments to analyse the risk factors for system risk mitigation and tax approaches.
Various materials used as root perforation repair material: A review
Authors: Sandhu Sukhpash Singh , Avasthi Abhishek , Gill Aashna , Sharma Aaron , Dhiman Akanksha , Angmo Deshan
Published: January 2023

Any type of communication that is present artificially between the root canal and the surrounding tissue is known as a root perforation. Root perforation ultimately results as a complication in the treatment procedure and deteoritates the final outcome of the treatment. There are various materials used in the treatment of the root perforation and every material is having its own advantages over the other material.
Application of atomic force microscopy in conservative dentistry and endodontics - A short review
Authors: Jayakumar Srilekha , Balu Manoj Kumar , Albert Merlin Maria , Arumugam Karthikeyan , Pulidindi Hema
Published: January 2023

AFM has evolved into one of the most used imaging tool in the fields of physics, biology and material science. AFM is based on mapping of an atomic-force field on a surface of materials with nondestructive probes. It provides a detailed topographical investigations and three-dimensional image of an object surface. One of the main advantages of the AFM method is the flexibility of the conditions in which it is used. AFM imaging can be conducted in an ambient or liquid environment with minimal compromise to its resolution.
Bioceramics in endodontics – A review
Authors: Geogi Chris Cherian , Rawat Ananya , Dubey Sandeep , Singh Palak
Published: January 2023

The field of dentistry is constantly changing with the introduction of new materials and techniques that resulted in good treatment outcome.Bio-ceramics are amongst the recently introduced materials which have changed the face of dentistry. Bioceramics are biocompatible, nontoxic, non-shrinking and usually chemically stable within the biological environment.The development of bioceramic based materials has greatly improved the dentist’s possibilities to successfully treat cases such as pulp capping, pulpotomy, apexification, apicoectomy and repair of defects caused by accidental perforation and resorption. The application of bioceramic materials has changed both surgical and non- surgical endodontic treatment, providing a promising direction for the preservation of patients’ teeth.
Occlusal re-establishment of posterior teeth using stamp technique- A case report
Authors: Nallagatla Vamsee Krishna , Chapati Jasmitha , Suma R Bharathi , Manduru Chandra Sekhar
Published: January 2023

According to Sturdevant, the main aim of restoration is to restore the form, function and occlusion of individual tooth which is mutilated by dental caries. To achieve all these factors many techniques and restorative materials have evolved in modern dentistry. Stamp technique is a new and decisive method for re-establishing the occlusal anatomy. In the present case report, a 15 year old male patient with occlusal caries on tooth number 37 is treated with composite restoration using stamp technique.
Patterns of bone marrow infiltration in lymphomas- A retrospective descriptive analysis from a tertiary care centre in Southern India
Authors: Anandani Garima M. , Manivannan Prabhu , Sree Rekha J  , Kar Rakhee , Basu Debdatta
Published: January 2023

Bone marrow biopsy (BMB) examination is the gold standard for staging of lymphoma which is interpreted along with other clinical, laboratory and radiological investigations. This study aimed to evaluate the various patterns of BMB infiltration by lymphomas which include Hodgkin and Non Hodgkin lymphoma and the usefulness of BMB compared to bone marrow aspiration (BMA).

: In a period of three years, there were 212 cases which showed lymphoma infiltration in bone marrow. We assessed the peripheral blood smear (PBS), BMA and BMB slides and concordance between each was evaluated. BMB slides were assessed for the pattern of involvement.

The most frequent subtype was chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) (21.70%) followed by Hodgkin lymphoma (HL)(12.73%)and follicular lymphoma (FL)(11.32%). Predominant pattern of infiltration showed by CLL/SLL cases was mixed pattern, by FL was paratrabecular pattern, mantle cell lymphoma(MCL) showed either diffuse or nodular, diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma(BL) showed predominantly diffuse pattern. Hairy cell leukemia (HCL) and peripheral T cell lymphoma (PTCL) showed an interstitial pattern. In HL, the pattern was usually focal nodular however diffuse involvement was seen in a few. Of the 212 cases, 50.94% cases had atypical lymphocytes or lymphocytosis in PBS and 81.14% cases showed infiltration in BMA.

Atypical lymphoid cells may not be present at times in peripheral blood or bone marrow aspirate in spite of infiltration in the bone marrow. Different lymphomas show characteristic patterns of marrow involvement.
Survivin and p53 expression in benign and malignant lesions of breast
Authors: Raj Swati , Soni Shristi , Aden Durre , Yadav Alka , Raj Sameeksha
Published: January 2023

Breast cancer is the most common malignancy in women, accounting for 14 % of all cancers in India; it accounts for < 1% of all cancer cases in men. Breast cancer is the leading cause of death worldwide. The study aims to assess the expression of p53 and Survivin in Fibroadenoma and Invasive carcinoma of no special type and its prognostic importance.

A total number of 75 cases are included in the study, out of which 34 are reported by two histopathologists as invasive carcinoma NST (ductal) and 41 reported as Fibroadenoma. All the cases included in the study are females. Immunohistochemistry for p53 and Survivin performed in both the groups with positive and negative controls. Cytoplasmic or nuclear IHC expression for Survivin is considered to be positive. Whereas, nuclear positivity is considered for p53. A semi quantitative scoring system performed consisting of intensity and % of positive cells.

The expression of Survivin and p53 is found to be high in IDC, 79% and 85% respectively. The correlation is found to be significant (p value = 0.002, Spearman Rho correlation). However, the expression of Survivin is seen in one third of all the cases of Fibroadenoma (37.5%) and p53 expression is expectedly low, seen in 12% cases.

Over expression of Survivin in IDC patients compared to benign cases is found to be correlated with p53 expression. Though Survivin is likely to contribute to apoptosis resistance, its expression is found to confer resistance to chemotherapy and radiotherapy in IDC. Henceforth, Survivin over expression along with p53 in invasive breast carcinoma defining overall poor prognosis and low survival rates.
Histopathological study of lesions of appendix
Authors: Khan Samrin Fatima Siraj , Momin Yasmin Altaf , Gosavi Alka Vikas , Waje Aasawari Arun
Published: January 2023

The human appendix is a supposedly funtionless organ, but can cause morbidity and mortality because it is likely to be infected. Acute Appendicitis being the most common surgical emergency. Appendicectomy specimens from suspected acute appendicitis often appear macroscopically normal but histological analysis reveal a more sinister underlying pathology.

A three year study was performed to determine the incidence of various non-neoplastic and neoplastic lesions of appendix.

To study the histopathology of various lesions of appendix.

It is a retrospective study for a period of three years at Tertiary care hospital. The histopathological reports and clinical details were collected and slides were reviewed and evaluated. Special stains were used wherever required.

The study included 1092 cases of lesions of appendix. The commonest lesion was chronic non-specific appendicitis (48.27%) followed by acute appendicitis with (47.80%). Other non neoplastic lesions found were fibrous obliteration of appendix (2.10%), chronic appendicitis with Enterobius vermicularis infestation (0.83), tuberculosis (0.18), xanthogranulomatous appendicitis (0.09%) and amoebic appendicitis (0.09%). Neoplastic lesions seen were low grade mucinous neoplasm (0.18) and serrated adenoma (0.09).

Chronic non-specific appendicitis is the commonest appendiceal lesion. The various lesions of appendix clinically present as acute or chronic appendicitis but histology reveals the true nature of the lesion and hence remains the gold standard method.
Paediatric geographic tongue (5year old boy): A case report with review of literature
Authors: Kaur Harpuneet , Sharma Prenika , Sharma Poornima
Published: January 2023

Geographic tongue often develops throughout childhood and affects between 1 and 2.5 percent of people worldwide. It is a benign, inflammatory condition that most frequently affects the tongue's dorsum and may spread to its lateral edges. The loss of filiform papillae and thinning of the epithelium are represented by the erythematous patches. It can be asymptomatic or patient may complains of pain and burning sensation. We report a case of 5 year old boy with early shedding of primary teeth, geographic tongue which was asymptomatic, had itchy skin lesions in the past and still gets the on and off episode of skin lesion ; with review of literature.
Sino-nasal and pharyngeal mass- Immunohistochemistry cuts the gordian knot
Authors: Geethamala K  , Jadhav Meena N , Sneha K  , Nirmala BL  , Haravi Rekha M , Patil Shirish
Published: January 2023

Sinonasal and pharyngeal mass lesion of Extraskeletal Ewing sarcomas (EEWSs) are extremely rare. Herein we present a case of EEWSs of ethmoid sinus extending into nasal and pharyngeal spaces mimicking as angiofibroma clinically. Histopathological examination in conjunction with immunohistochemistry puzzled out the diagnostic dilemma.
Primary spinal chordoma: A rarity in itself, with a rarity of its own
Authors: Aberna A.Keerthy , Rama K
Published: January 2023

Chordoma accounts for 1-4% of all primary malignant tumours of bone. Besides advances in rgical techniques and radiation therapy, tumour may recur locally or metastasize to distant sites with local recurrence being predominant form. Here we present a case report of primary spinal chordoma which recurred locally within a year of surgical excision. Chordoma of spine is a rare low grade malignant tumour with strong propensity for local recurrence. Long term follow up is usually recommended as there is high chance of recurrence and malignant transformation even after surgery followed by radiation therapy.
Rare cytogenetic abnormalities in MDS evolving from fanconi anemia-A case report
Authors: Rajendra Nidhi , Ramanathan Subbaiah , Ashok Vishal , Srivalli BS
Published: January 2023

Fanconi anemia (FA) is a genetically heterogenous rare autosomal recessive disorder. Mutations in FANCA gene are the most frequent among FA patients accounting for 60-65%. FA is characterised by congenital malformations, progressive bone marrow failure (BMF) and increased risk of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The risk of developing hematological abnormalities in FA patients is around 98% by 40 years of age. The risk of clonal cytogenetic abnormalities during BMF is around 67% by 30 years of age and risk of developing MDS or AML is 52% by 40 years of age. The frequent chromosomal abnormalities are 1q+, monosomy 7 and gains of 3q. Partial duplications/triplications of chromosome 1q are known to represent a nonrandom chromosomal anomaly in myeloid disorders.
Concomitant squamous cell carcinoma and actinomycosis—An unique and rare occurrence
Authors: Kadam Sameer A , Hoogar MB  , Valand Arvind , Bhonsale Vaishali , Pardesi Kirti , Sampat Nakul
Published: January 2023

: Actinomycosis of the oral cavity is not common, though actinomyces species often occur as normal commensals in the oral cavity. They gain entry into deep tissue to cause infection and consequent tissue damage whenever there is damage to the oral mucosa by injury or infection or neoplastic process.

The case being discussed here is of a male, aged 62 years, who presented with an ulcero-proliferative lesion over left buccal mucosa. A punch biopsy was carried out on the lesion. Histopathology laboratory received three gray-white tissue pieces. Histological examination of the tissue pieces revealed features of moderately to poorly differentiated squamous cell carcinoma. Few colonies of radiating filamentous structures reminiscent of colonies of actinomyces species were noted. The sections were further stained with relevant stains for filamentous bacteria such as Periodic Acid Schiff (PAS) stain which confirmed the colonies of Actinomyces spp.

The case being submitted here is an unique and relatively rare finding of concomitant squamous cell carcinoma and oral actinomycosis with only few cases being reported in publish English medical literature.
Malignant intracerebral nerve sheath tumour of the brain presenting as a recurrent meningioma
Authors: Zaheer Sufian , Aden Durre , Ranga Sunil
Published: January 2023

A malignant intracerebral nerve sheath tumour (MINST) is a variant of MPNST arising inside the brain. They are very rare tumours that are aggressive and have strong metastatic potential. We report a case of a recurrent lesion in the brain in a 39 years male who presented as recurrent meningioma. It was finally reported as MINST with histopathology and immunohistochemistry. Surgical excision is the treatment of choice. The patient is on follow-up after an uneventful surgical excision. To the best of our knowledge, very few cases of malignant intracerebral nerve sheath tumours have been reported so far in the literature. This case is presented not only for its rarity but also to highlight that this aggressive tumour needs to be kept in mind while diagnosing such lesions with these histomorphological findings.
Characteristic yet unusual presentation of an odontogenic myxoma in the anterior mandible
Authors: Sachdev Sanpreet Singh , Wadde Kavita , Chowdhar Asha , Mathe Prachi
Published: January 2023

Odontogenic myxoma (OM) is a rare benign odontogenic tumor characterized by stellate and spindle-shaped cells dispersed in an abundant myxoid extracellular matrix. The bony invasion by the tumor imparts a characteristic ‘soap bubble’, ‘honeycomb’, or ‘tennis racquet’ radiographic appearance to the lesion. The decision of adopting a conservative or radical approach also depends on various factors such as location, size, and duration of the lesion, and age, gender, and expectations of the patient. Therefore, adequate treatment planning is crucial for the management of cases of OM and varies on an individual basis. The present case report described the management of a case of unusually large OM occurring in a 31-year-old Indian female in the mandibular anterior region crossing the midline.
Hibernoma-A rare tumor on rare site
Authors: Mishra Himachal , Alexander Manika
Published: January 2023

Hibernoma is a rare benign tumor that originates from brown fat. Hibernoma is thought to arise from areas containing residual brown fat like- the interscapular area, axilla, neck, chest, abdominal cavity, and retroperitoneum. The incidence of this rare tumor has very rarely been reported to occur over the forehead. Being a benign tumor, no association of malignant transformation or metastasis has been reported.

A 23-year-old male presented with a complaint of a painless non-progressive swelling over the forehead for the past 6 months. On examination, the swelling was 2x2 cm, soft, mobile, non-tender, and non-pulsatile with no skin changes. FNAC did which shows sheets and clusters of adipocytes with abundant foamy cytoplasm and reported as “Hibernoma”. The patient has been asked to follow up and for the last 1 year, the tumor is still non-progressive with no pressure symptoms and hence has not undergone surgery.

Hibernoma is a rare benign tumor of brown fat tissue which constitutes only 1.6% of benign lipomatous tumors but their actual prevalence is still unknown. This tumor very rarely may occur in the forehead area although incidence over the forehead has rarely been reported. Since this tumor is slow growing, painless non-progressive; it mostly presents as an asymptomatic tumor. It has to be included in the differential diagnosis of adipocyte-containing tumors to prevent false treatment.
Construction of quite interpretable non-elementary linear regression models
Authors: Bazilevskiy Mikhail P.
Published: January 2023

Subject of research: mixed-integer 0-1 linear programming problem for choosing optimal structures for non-elementary linear regression models.
Purpose of research: integrate into the mixed-integer 0-1 linear programming problem additional constraints that will guarantee the construction of quite interpretable non-elementary linear regressions.
Methods of research: regression analysis, mathematical programming, method of successive increase the absolute contributions of variables to the general determination.
Object of research: non-elementary linear regression models.
Main results of research: in the mixed-integer 0-1 linear programming problem, designed to construct non-elementary regressions, additional linear constraints on the absolute contributions of variables to the general determination are integrated, allowing you to control both the contributions themselves and multicollinearity in the model. It is shown how it is necessary to regulate these constraints so that the non-elementary linear regression obtained as a result of solving the problem is quite interpretable. The proposed mathematical apparatus was used to model railroad freight transportation in the Tyumen region. An interpretation of the obtained high-precision and quite interpretable non-elementary linear regression is given.
Application of genetic algorithms to optimize solution of filtering and prediction problems in dynamic program testing systems
Authors: Polukhin Pavel V.
Published: January 2023

Subject of research: probabilistic time models of testing created to form complex stochastic connections between individual test elements and developed to detect certain groups of the web applications program errors.
The purpose of research: substantiate the possibility of using genetic algorithms in the process of solving probabilistic testing problems based on a multi-particle filter and evaluate their effectiveness. The study provides fundamental methods to improve the accuracy of the posterior distribution of probabilistic testing models and the total number of matched with evidences samples.
Methods and objects of research: object of the research is to solve filtering and smoothing problems for a probabilistic test model based on a multi-particle filter. Methods and algorithms based on the Monte Carlo method are presented, allowing, in combination with genetic algorithms, to increase the accuracy of obtaining posterior estimates of samples. This approach allows you to narrow the range of samples, as well as increase their consistency. The formation of each next sample will be carried out taking into account the previous ones through the use of crossover and mutation operations.
The main results of research: as a result, the validity of the proposed approaches to solving filtration and prediction problems in the process of implementing testing procedures based on multi-particle filter algorithms and genetic algorithms was proved. The given practical results prove the constructiveness and scientific validity of the proposed methods and algorithms for solving web applications testing problems.
Time perspective and orientation of teachers with different attitudes to time
Authors: Dukhnovsky Sergey V. , Prokopyev Dmitry L.
Published: January 2023

The article with the involvement of empirical data reveals the problem of the temporary organization of the life and activities of teachers.
Subject of research: characteristics of the time perspective and orientation of teachers with time freedom, dependence, infantilism, as types of relation to time.
Purpose of research: peculiarities of the time perspective and orientation of teachers with a different attitude to time.
Methods and objects of research: the respondents were 174 teachers teachers of secondary schools. They used a psychodiagnostic complex, which includes author's developments the "Scale of subjective attitude to time" and the "Time" questionnaire, as well as the "Time Perspective Questionnaire" (F. Zimbardo).
Main results of research: it has been established that teachers with temporary infantilism are characterized by a "negative past and orientation towards the future". They are characterized by a harmonious temporal orientation they strive to move into the future, using the resources of the past, but in the present. Teachers with temporary dependence are distinguished by a "positive past and ascetic present". In a temporary orientation, teachers with this attitude to time are more focused on the future ("live" them) than on the present and past. Teachers with temporary freedom are characterized by a temporary perspective distinguished by a "fatalistic ascetic present with an orientation towards the future". Nevertheless, in a temporary orientation, teachers focus more on the past than on the present and future, trying to use the resources of past experience to develop themselves and their potential.
The crisis of criminal punishment: the state and conditioning
Authors: Melyukhanova Evgeniya E.
Published: January 2023

Subject of research: the institution of criminal punishment, the state of which is often assessed as a crisis. The debatable nature of the issue of the crisis of criminal punishment generates diametrically opposite judgments about the presence of a crisis, or about its absence.
Purpose of research: to determine the presence or absence of a state of crisis of criminal punishment, as well as the conditionality of the existence of discussions about the crisis of criminal punishment.
Methods and objects of research: the dialectical method of cognition of socio-legal phenomena is used as the methodological basis of the study. General scientific methods of cognition (analysis, synthesis), private scientific (formal-logical, epistemological) were used.
Main results of research: In conclusion, the author comes to the conclusion that close attention should be paid not to the search for alternatives to criminal punishment, but to the problems of its use (appointment and execution of punishment). The establishment of the rules of sentencing corresponding to modern realities will ensure an increase in its effectiveness, uniformity of law enforcement practice and will contribute to overcoming the so-called "punishment crisis".
Measurement of residual stresses after vibroimpulsive hardening of specimen
Authors: Galimov Engel R. , Tyurin Andrey V.
Published: January 2023

Subject of research: technique for determining residual stresses of the first kind, in samples that are cut from the spar after vibration shock hardening.
Purpose of research: to increase the accuracy, as well as to improve the methodology for determining residual stresses.
Methods and objects of research: the object of the study is residual stresses and the algorithm of their processing. The study used a modified order of approximation of data obtained from sensors.
Main results of research: a new algorithm for processing experimental data is presented, which allows us to obtain more advanced results of studies of residual stresses in samples. A mathematical model of data processing has been developed to implement the algorithm. This mathematical model for determining residual stresses in the structure has a modified order of approximation of data obtained from sensors. Approximation by a polynomial of the sixth degree occurs before the plot is calculated and constructed, and not after its construction and subsequent smoothing, as was implemented earlier. This technical solution contributes to improving the accuracy and correctness of studies for determining residual stresses.
An overview of classical ottoman art of fabric
Authors: Ozkan Nurhan
Published: January 2023

Seljuk Turks who began to settle in Anatolia since 11th century showed a great improvement in this area by combining the weaving tradition that they carried from Central Asia, Transoxiana, Khwarezm and Iran with the savings in Anatolia (Ãœlgen, 1996). Turkish fabrics began to get their most characteristic motifs and a thin and a perfect weaving technique just to the end of 15th century. Reaching its highest level in 16thcentury, our fabric weaving technique improved after such a long development cycle (SÃ¼slÃ¼, 1976).All the arts had their golden age during the classical Ottoman Period. It is also the most magnificent age for 16th century Turkish fabric art. It has been effective in the selection of topic that fabrics wear out in time and design schemas on them face the danger of evanescence because of their raw materials.In this research, relevant resources have been searched and fabric figure drawings were drawn by taking photos from the museums that have classical Ottoman Period fabrics. The weaving centers, raw materials, colors and figures of classical Ottoman Period fabrics have been established and has set out the importance of the Classical Ottoman fabric art.

Keywords: Fabric, Art, Classical Period