bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges and Performance of Filter Dusts as a Supplementary Cementitious Material
Authors: Berger Johannes , Mocciaro Anabella , Cordoba Gisela , Martinefsky Cecilia , Irassar Edgardo F. , Beuntner Nancy , Scherb Sebastian , Thienel Karl-Christian , Tironi Alejandra
Published: November 2024

Global industry relies on a linear approach for economic growth. One step towards transformation is the implementation of a circular economy and the reclamation of anthropogenic deposits. This study examines two filter dusts, one German and one Argentinian, from the production of calcined clays, representing such deposits. Investigations and comparisons of untreated and calcined filter dust and the industrial base product pave the way for using waste product filter dust as supplementary cementitious material (SCM). In the future, some twenty thousand tons of contemporary waste could potentially be used annually as SCM. The results confirm the suitability of one material as a full-fledged SCM without further treatment and a measured pozzolanic reactivity on par with fly ash. Sample materials were classified into two groups: one was found to be a reactive pozzolanic material; the other was characterized as filler material with minor pozzolanic reactivity. Additionally, important insights into the physical properties of oven dust and heat-treated oven dust were obtained. For both material groups, an inversely proportional relationship with rising calcination temperatures was found for the specific surface area and water demand. The impact of the calcination temperature on both the particle size distribution and the potential to optimize the reactivity performance is presented.
Biomechanical Finite Element Analysis of Two Types of Short-Angled Implants Across Various Bone Classifications
Authors: Ceddia Mario , Romasco Tea , De Bortoli Nilton , Mello Bruno Freitas , Piattelli Adriano , Mijiritsky Eitan , Di Pietro Natalia , Trentadue Bartolomeo
Published: November 2024

The aim of this finite element analysis (FEA) was to investigate the distribution of von Mises stress within dental implant components, as well as trabecular and cortical bone. The study considered various bone qualities that influence cortical thickness in contact with the implant, specifically examining cortical thicknesses of 0.5, 1.5, and 3 mm, corresponding to Bergkvist’s classifications IV, III, and II, respectively. A simplified 3D model of the bone was developed for the analysis. Two short implants were inserted into the model: one with a 30° inclined abutment (IA) and another positioned at a 30° angle featuring a straight abutment (II). A vertical force (120 N) was applied to the upper surface of the abutments. FEA software was employed to assess the stresses on the peri-implant tissues and the implants. The findings indicated that a reduction in cortical bone thickness results in an increase in stress within the cortical bone. For IA, the stresses recorded 32.56, 56.12, and 96.14 MPa for cortical thicknesses of 3, 1.5, and 0.5 mm, respectively. Conversely, II exhibited increased stresses across all bone qualities (52.32, 76.15, and 126.32 MPa for the same cortical thicknesses). It is advisable to avoid II in cases of poor bone quality and thin cortical due to the heightened risk of overload-induced bone resorption; however, it may be preferable to use IA in scenarios involving good bone quality and thicker cortical.
A Starting Point on Recycling Land and Sea Snail Shell Wastes to Manufacture Quicklime, Milk of Lime, and Hydrated Lime
Authors: Ferraz Eduardo , Terroso Denise , Sequeira Maria Cristina , Azevedo Maria Celeste , Coroado João , Monteiro Carlos , Rocha Fernando , Gamelas José A. F.
Published: November 2024

The valorization of gastropod shell wastes in the production of lime is the topic of this study. First, shells from land snail and sea snail were characterized for their mineralogical, chemical, and thermal properties. Then, the shells were calcined at 1000 °C, and the obtained quicklimes were characterized for their specific surface area, pore diameter, and particle morphology, followed by evaluation of their reactivity in wet slaking tests. Comparisons were made with lime from limestone. It was found that both gastropod shell wastes were composed of aragonite as the dominant crystalline phase. The quicklime from land snail belonged to the most reactive class (R5) of the wet slaking reactivity, reaching 60 °C in about 5 min, whereas the quicklime from the sea snail belonged to the R4 class, reaching 60 °C in about 14 min. However, both were much less reactive than the lime from limestone (60 °C in 25 s). The lower reactivity of quicklime from sea snail shells compared to quicklime from land snail shells could be related to its higher sulfur content (as contaminant), lower pore diameter, and the presence of particles with rounder surfaces. The reference quicklime from limestone was more reactive, mainly due to the much higher specific surface area and lower particle size. It was concluded that the gastropod shell wastes can be used in lime manufacturing.
Thermodynamic Study of the Sustainable Hydrometallurgical Treatment of Copper Converter Flue Dust Based on Pb, Zn, and Sn Oxides
Authors: Kollová Alexandra , Laubertová Martina , Trpčevská Jarmila , Sisol Martin
Published: November 2024

The presented article deals with the thermodynamic study of copper converter flue dust (CCFD) treatment by hydrometallurgical process. The investigated sample of CCFD contains 38.31 wt.% Zn, 11.35 wt.% Pb, and 2.92 wt.% Sn in the form of oxides (PbO, ZnO, and SnO2). The leaching of CCFD in sulphuric acid, acetic acid, nitric acid, and sodium hydroxide was thermodynamically studied. Using Pourbaix diagrams for individual metal–S/C/N/Na/–H2O systems, the possibility of leaching oxides in selected leaching agents was confirmed. A sustainable and environmentally friendly method of processing the sample of CCFD using a hydrometallurgical method is proposed. A suitable selective leaching agent is the acetic acid solution. When leaching in an acetic acid solution, zinc and lead are chemically dissolved to form acetates Zn(CH3COO)2(aq) in the form of Zn2+(aq) at a temperature of 20 °C with a pH range of 0–3.5 and at a temperature of 80 °C with a pH range of 0–2.95, as well as Pb(CH3COO)2(aq) as Pb2+(aq) at a temperature of 20 °C with a pH range of 0–1.95 and at a temperature of 80 °C with a pH range of 0–2, respectively, while tin remains as a solid residue in the form of SnO2(s) at the temperatures of 20 °C and 80 °C throughout the whole acidic pH range. Various analytical techniques, such as SEM, EDX, XRD, and AAS, were used to analyse samples before a thermodynamic study of the leaching of CCFD was conducted by applying Pourbaix Eh–pH diagrams.
Microstructure and Hardness of Nickel-Based Coatings Prepared by Laser Additive Manufacturing on Water-Cooled Substrate: An Experimental and Numerical Study
Authors: Yan Mingjun , Li Ruifeng , Guo Jiajunqi , Liu Bin , Zhang Xiaoqiang , Zhao Yue , Li Taotao , Qiao Lei , Elmi Hosseini Seyed Reza
Published: November 2024

The excess heat generated during the laser additive manufacturing process is prone to cause coating defects; a water-cooled substrate can effectively remove the excess heat and improve the hardness of the coating. In this study, the effects of water-cooled substrate on the microstructure and hardness of laser additive manufactured nickel-based coatings were investigated by experimental and numerical simulations. The results showed that the water-cooled substrate decreased the size of columnar crystals and increased the number as well as the length of secondary dendrite crystals at the bottom of the nickel-based coatings. There was also a noticeable increase in the size of equiaxed grains and the quantity of the solid solution in the middle of the coatings. The hardness value of the coating increased at the water velocity of 200 mL/s and 500 mL/s and finally decreased at 700 mL/s. A finite element model was established by ABAQUS software to numerically simulate the temperature field of the laser additive manufactured nickel-based coating with the water-cooled substrate. The results revealed significant differences in the temperature distribution of the coatings with different velocities. As the water velocity increased, the peak temperature at the center of the coating’s molten pool gradually decreased. In addition, the cooling rate of the specimens increased with the application of the water cooling, leading to a more concentrated temperature distribution near the laser heat source.
Projectile Penetration into Calcareous Sand Subgrade Airport Runway Pavement with Genetic Algorithm Optimization
Authors: Peng Chucai , Huang Jingnan , Sun Xichen , Nan Yifei , Chen Yaohui , Chen Kun , Feng Jun
Published: November 2024

As an important civil and military infrastructure, airport runway pavement is faced with threats from cluster munitions, since it is vulnerable to projectile impacts with internal explosions. Aiming at the damage assessment of an island airport runway pavement under impact, this work dealt with discrete modeling of rigid projectile penetration into concrete pavement and the calcareous sand subgrade multi-layer structure. First, the Discrete Element Method (DEM) is introduced to model concrete and calcareous sand granular material features, like cohesive fracture and strain hardening due to compression, with mesoscale constitutive laws governing the normal and shear interactions between adjacent particles. Second, the subsequent DEM simulations of uniaxial and triaxial compression were performed to calibrate the DEM parameters for pavement concrete, as well as subgrade calcareous sand. Prior to the multi-layer structure investigations, penetration into sole concrete or calcareous sand is validated in terms of projectile deceleration and depth of penetration (DOP) with relative error ≤ 5.6% providing a reliable numerical tool for deep penetration damage assessments. Third, projectile penetration into the airport runway structure with concrete pavement and calcareous sand subgrade was evaluated with validated DEM model. Penetration numerical simulations with various projectile weight, pavement concrete thickness as well as striking velocity, were performed to achieve the DOP. Moreover, the back-propagation (BP) neural network proxy model was constructed to predict the airport runway penetration data with good agreement realizing rapid and robust DOP forecasting. Finally, the genetic algorithm was coupled with the proxy model to realize intelligent optimization of pavement penetration, whereby the critical velocity projectile just perforates concrete pavement indicating the severest subsequent munition explosion damage.
The Influence of Horsetail (Equisetum arvense L.) Powder and Horsetail-Based Silica on the Crystallization Kinetics of Polylactide
Authors: Mysiukiewicz Olga , Szulc Joanna , Miklaszewski Andrzej
Published: November 2024

Biogenic silica (SiO2) sourced from living organisms, especially plants such as rice and other cereals, has recently been successfully applied in different polymeric compositions. Another rich source of biogenic silica is common horsetail (Equisetum arvense L.), containing up to 25% SiO2 in the dry matter. In this study, biogenic silica was obtained from horsetail powder by acid leaching in sulfuric acid and calcination at 400 °C. The analysis, including measurements of specific surface area using the Brunauer–Emmett–Teller method, assessment of crystallinity by X-ray diffraction, as well as chemical content analysis by Fourier-transform infrared spectroscopy showed that high-purity, high-surface mesoporous silica was obtained. The biogenic silica and horsetail powders were also introduced to polylactide (PLA) to determine their influence on the polymer’s crystallization, which was studied in both non-isothermal and isothermal conditions by differential scanning calorimetry. The crystallization parameters were calculated according to the Avrami method based on isothermal crystallization curves at 100, 110 and 120 °C. The crystalline structures were observed by optical microscopy in polarized light. It was found that both fillers improve the crystallization of PLA, especially in low-supercooling conditions, so they can be successfully utilized in industrial applications, when high crystallinity of polylactide is needed.
Amber “Alchemy”: Recreating and Investigating Yellow Glass Formulations
Authors: Reis Santos Catarina , Ruivo Andreia , Carneiro Ana , Veiga João Pedro , Palomar Teresa , Coutinho Inês
Published: November 2024

Amber glass has been produced since at least the 6th century BC. Its value derives from its ability to mimic natural amber and, later, from its ultraviolet filtering properties. Until the 19th century, amber glass was widely used for the storage of food and medicines because its protective properties had been empirically recognized. This study investigates historical methods of amber glass production by using glass recipes from four Portuguese arcana (1793–1975) and focusing on Fe-S and Fe-Mn chromophores. Five recipes were reproduced under controlled laboratory conditions, resulting in 21 experiments. Of these, only 10 produced amber glasses were with different shades. Chemical compositions were analysed by WDXRF, while DSC and dilatometry were used to assess thermal properties. Vickers hardness tests and UV–visible absorption spectroscopy provided insight into mechanical strength and chromophore presence. The study found that FeS amber glass was more difficult to produce than Fe-Mn amber glass, given the complex variables involved in the former, such as SO3 volatility affecting the final product. Reproduction of historical recipes showed that, even without modern chemical knowledge, historical glassmakers developed practical, empirical methods for making amber glass. These findings contribute to a broader understanding of glass conservation and highlight the importance of historical glass recipes for the interpretation and conservation of glass objects.
An Ultra-Fast Validated Green UPLC-MS/MS Approach for Assessing Revumenib in Human Liver Microsomes: In Vitro Absorption, Distribution, Metabolism, and Excretion and Metabolic Stability Evaluation
Authors: Attwa Mohamed W. , Abdelhameed Ali S. , Kadi Adnan A.
Published: November 2024

Background and Objectives: Revumenib (SNDX-5613) is a powerful and specific inhibitor of the menin–KMT2A binding interaction. It is a small molecule that is currently being researched to treat KMT2A-rearranged (KMT2Ar) acute leukemias. Revumenib (RVB) has received Orphan Drug Designation from the US FDA for treating patients with AML. It has also been granted Fast Track designation by the FDA for treating pediatric and adult patients with R/R acute leukemias that have a KMT2Ar or NPM1 mutation. Materials and Methods: The target of this research was to create a fast, precise, green, and extremely sensitive UPLC-MS/MS technique for the estimation of the RVB level in human liver microsomes (HLMs), employing an ESI source. The validation procedures were carried out in accordance with the bioanalytical technique validation requirements established by the US Food and Drug Administration that involve linearity, selectivity, precision, accuracy, stability, matrix effect, and extraction recovery. The outcome data of the validation features of the UPLC-MS/MS approach were acceptable according to FDA guidelines. RVB parent ions were formed in the positive ESI source and its two fragment ions were estimated employing multiple reaction monitoring (MRM) mode. The separation of RVB and encorafenib was achieved using a C8 column (2.1 mm, 50 mm, and 3.5 µm) and isocratic mobile phase. Results: The RVB calibration curve linearity ranged from 1 to 3000 ng/mL (y = 0.6515x − 0.5459 and R2 = 0.9945). The inter-day precision and accuracy spanned from −0.23% to 11.33%, while the intra-day precision and accuracy spanned from −0.88% to 11.67%, verifying the reproducibility of the UPLC-MS/MS analytical technique. The sensitivity of the developed methodology demonstrated its capability to quantify RVB levels at an LOQ of 0.96 ng/mL. The AGREE score was 0.77, confirming the greenness of the current method. The low in vitro t1/2 (14.93 min) and high intrinsic clearance (54.31 mL/min/kg) of RVB revealed that RVB shares similarities with medications that have a high extraction ratio. Conclusions: The present LC-MS/MS approach is considered the first analytical approach with the application of metabolic stability assessment for RVB estimation in HLMs. These methods are essential for advancing the development of new pharmaceuticals, particularly in enhancing metabolic stability.
The Association of Thyroid Disease with Risk of Dementia and Cognitive Impairment: A Systematic Review
Authors: Alšauskė Silvija Valdonė , Liseckienė Ida , Verkauskienė Rasa
Published: November 2024

Background and Objectives: Cognitive impairment is defined as a reduced ability to perform one or more cognitive functions, potentially leading to dementia if the condition worsens. With dementia being a rapidly growing public health issue affecting approximately 50 million people worldwide, understanding modifiable risk factors such as thyroid disease is crucial for prevention and early diagnosis. Thyroid hormones play a vital role in brain development and functioning, impacting processes such as neuron growth, myelination, and neurotransmitter synthesis. Recent decades have seen thyroid disorders emerging as potential independent risk factors for reversible cognitive impairment. Materials and Methods: The review adheres to PRISMA guidelines, utilizing a structured PICO question to explore whether individuals with thyroid diseases have a higher risk of developing dementia and cognitive impairments compared to those without. The literature search was conducted in PubMed, Cochrane, and ScienceDirect databases, including studies published from 1 January 2019 to 31 December 2023. The literature review discusses nine selected articles. Results: The findings highlight a complex association between thyroid dysfunction and cognitive decline, with some studies indicating significant links, particularly with hypothyroidism, and others suggesting the relationship may depend on the specific type of thyroid dysfunction or cognitive domain affected. Six out of nine articles found a link between thyroid disease and cognitive impairment, while three articles refuted this link. Conclusions: The review reveals a complex and ambiguous relationship between thyroid dysfunction and cognitive impairment. Further research is needed to elucidate the mechanisms underlying these associations and to determine whether thyroid dysfunction may be a modifiable risk factor for dementia.
Study of the Solidification Microstructure and Deformation Behaviour of Cu20Fe Alloy
Authors: Niu Wenyong , Huang Su , Lin Baosen , Li Jianping
Published: November 2024

In this paper, the solidification microstructure characteristics of metastable immiscible Cu20Fe alloys under natural cooling conditions and subsequent cold rolling were analysed. The findings demonstrate that the Cu20Fe alloy underwent a liquid–solid transformation under natural cooling conditions. The equiaxed Cu matrix and the Fe dendrites exhibited elongation into ribbon-like structures parallel to the cold rolling direction. Following cold rolling, the mean grain size of the Cu20Fe alloy was considerably refined, and the mechanical properties were improved. After cold rolling, the Cu matrix formed both {112}<111> copper and {110}<112> brass textures. Furthermore, the strengthening mechanisms of the cold-rolled Cu20Fe alloy are primarily dependent on the strengthening of grain boundaries and work hardening. This provides an economically friendly method for the preparation of Cu-Fe alloys with high Fe compositions.
Singlet Oxygen-Induced Mitochondrial Reset in Cancer: A Novel Approach for Ovarian Cancer Therapy
Authors: da Veiga Moreira Jorgelindo , Schwartz Laurent , Jolicoeur Mario
Published: November 2024

Background/Objectives: This study explores the generation of singlet oxygen (SO) through methylene blue (MB) activation as a metabolic intervention for ovarian cancer. We aimed to examine the role of SO in modulating mitochondrial function, cellular metabolism, and proliferation in ovarian cancer cell lines compared to control cells. Methods: The study utilized two ovarian cancer cell lines, OV1369-R2 and TOV1369, along with ARPE-19 control cells. Following MB treatment and light activation, mitochondrial function and ATP synthesis were assessed. Metabolomic analyses were performed to evaluate changes in central carbon metabolism, particularly focusing on markers of the Warburg effect. Results: TOV1369 cells exhibited a pronounced sensitivity to MB treatment, resulting in significant inhibition of ATP synthesis and reduced proliferation. Metabolomic analysis indicated that MB-induced SO production partially reversed the Warburg effect, suggesting a shift from glycolysis to oxidative phosphorylation. These effects were less pronounced in OV1369-R2 and ARPE-19 cells, correlating with their lower MB sensitivity. Conclusions: MB-generated SO selectively modulates mitochondrial energetics in ovarian cancer cells, driving a metabolic reorganization that curtails their proliferative capacity. This approach, leveraging the bacterial-like features of cancer metabolism, offers a promising therapeutic avenue to induce apoptosis and enhance treatment outcomes in ovarian cancer.
Robust Control Strategy of Acoustic Micro Robots Based on Fuzzy System
Authors: Dong Junjie , Duan Xingguang
Published: November 2024

This study presents a robust control strategy for acoustic micro robots utilizing a novel interval type-three fuzzy system. Micro robots driven by acoustic forces face significant challenges in fluid environments due to complex nonlinearities, uncertainties, and disturbances. To address these issues, we propose a control framework that combines fuzzy logic and sliding mode control to enhance the stability and trajectory tracking performance of micro robots under varying fluid conditions. The interval type-3 fuzzy logic system provides increased robustness by better handling external disturbances and uncertainties compared to the robustness of the traditional methods. The experimental results from one-dimensional, two-dimensional, and three-dimensional fluid cavities demonstrate that the proposed control method significantly improves tracking accuracy, reducing the errors in complex environments. This control framework offers promising potential for the precise manipulation of micro robots in biomedical applications and other microfluidic systems. The minimum trajectory tracking control mean square error is 12.82 μm.
Study on the Abrasive Blasting Mechanism of Solder Welded 304V Wire in Vascular Intervention
Authors: Liu Yao , Zhai Shaobo , Guo Jinzhu , Fu Shiling , Shen Bin , Zhao Zhigang , Ding Qingwei
Published: November 2024

The solder burrs on the 304V wire surface can easily scratch the vascular tissue during interventional treatment, resulting in complications such as medial tears, bleeding, dissection, and rupture. Abrasive blasting is often used to remove solder burr and obtain a smooth surface for the interventional device. This study conducted an abrasive blasting experiment to explore the effects of process parameters (air pressure, lift-off height, abrasive volume, and abrasive type) on processing time, surface roughness, and mechanical properties to reveal the material removal mechanism. The results indicated that the resin abrasive can remove the SAC burr and keep the 304V integrity due to the proper hardness and Young’s module. Impaction pits are the main material removal mode in abrasive blasting. The processing time decreases with the increase in air pressure. The surface roughness increases with the increase in abrasive volume. The primary and secondary factors affecting the surface roughness of the 304V wire after abrasive blasting are the abrasive type and air pressure, followed by the abrasive volume and lift-off height. Blasting leads to a decrease in yield strength, and Young’s modulus and the hardness of the abrasive will affect the tensile strength. This study lays a foundation for understanding abrasive blasting and different cutting mechanisms.
Photocatalytic Degradation of Methylene Blue by Surface-Modified SnO2/Se-Doped QDs
Authors: Alamo-Nole Luis , Bailon-Ruiz Sonia J.
Published: November 2024

Developing new nanomaterials and performing functionalization to increase their photocatalytic capacity are essential in developing low-cost, eco-friendly, and multipurpose-capacity catalysts. In this research, SnO2/Se-doped quantum dots (QDs) covered with glycerol (SnO2/Se-GLY) were synthesized using microwave irradiation. Then, their cover was replaced with glutaraldehyde through a ligand exchange procedure (SnO2/Se-GLUT). The XRD analyses confirmed a tetragonal rutile structure of SnO2. The HR-TEM analysis confirmed the generation of QDs with a size around 8 nm, and the optical analysis evidenced low bandgap energies of 3.25 and 3.26 eV for the SnO2/Se-GLY and SnO2/Se-GLUT QDs, respectively. Zeta-sizer analysis showed that the hydrodynamic sizes for both nanoparticles were around 230 nm (50 mg/L), and the zeta potential confirmed that SnO2/Se-GLUT QDs were more stable than SnO2/Se-GLY QDs. The cover-modified QDs (SnO2/Se-GLUT) showed a higher and faster adsorption capacity, followed by a slower photocatalytic process than the original QDs (SnO2/Se-GLY). The QTOF-LC-MS analysis confirmed MB degradation through the identification of intermediates such as azure A, azure B, azure C, and phenothiazine. Adsorption isotherm analysis indicated Langmuir model compliance, supporting the high monolayer adsorption capacity and efficiency of these QDs as adsorbent/photocatalytic agents for organic pollutant removal. This dual capability for adsorption and photodegradation, along with the demonstrated reusability, highlights the potential of SnO2/Se QDs in wastewater treatment and environmental remediation.
A Metabarcoding Approach for Investigating the Stomach Microbiota of the Corallivorous Snail Coralliophila meyendorffii (Muricidae, Coralliophilinae) and Its Venomous Host, the Sea-Anemone Parazoanthus axinellae (Zoanthidea, Parazoanthidae)
Authors: Benvenuti Chiara , Fassio Giulia , Russini Valeria , Modica Maria Vittoria , Oliverio Marco , Davolos Domenico , Nocella Elisa
Published: November 2024

The corallivorous snails Coralliophila meyendorffii and its coral host Parazoanthus axinellae are appealing candidates for studying symbiotic interactions at the microbiome level. In this study, we investigated for the first time the microbial community in the stomach of C. meyendorffii and in the polyps of its coral host P. axinellae using as markers multiple regions of the 16S rRNA gene. The bacterial community in the stomach of another corallivorous snail, Babelomurex cariniferus, that feeds on Cladocora hexacorals, was also investigated for comparison. The obtained results indicated the phylum Proteobacteria as the most abundant among the analysed samples, with Alphaproteobacteria and Gammaproteobacteria as the main classes. Among the investigated communities, some bacterial taxa were recognised in line with previous findings in the microbiota of marine invertebrates. As both organisms are exposed to the same bacteria in their habitats, this might suggest shared environmental influences for their microbiota composition. Most of the detected taxa found exclusively or predominantly in P. axinellae samples suggest the presence of holobiont components within the microbial community of this coral, mirroring those identified in other corals, while the stomach microbiome of C. meyendorffii did not indicate a primary role in parasitism. Finally, we provide evidence that many of these bacterial taxa are horizontally transferred between Parazohantus and Corallliophila.
Bismuth Sulfosalts from the Nistru Metallogenetic Field, Baia Mare Zone, NW Romania
Authors: Damian Floarea , Damian Gheorghe , Cook Nigel J. , Prokofiev Vsevolod Yu. , András Peter
Published: November 2024

An association of bismuth sulfosalts coexisting with native gold is described from a sulfide-rich copper vein in the Nistru area, Baia Mare metallogenetic district, NW Romania. This mineralization is hosted within a Neogene calc-alkaline subvolcanic porphyry quartz-micromonzodiorite stock on the southern border of the Gutâi Mountains. Cu+Au+Bi mineralization represents the inner part of a zoned vein of a type specific to the SE part of the Nistru orefield. The Pb-Zn and Au-Ag veins are located towards the external zone at the boundary of the stock with the surrounding rocks. Bismuth sulfosalts are mainly represented by bismuthinite derivatives and members of the lillianite homologous series. Cosalite, matildite and wittichenite are also present in subordinate amounts. Bi-rich members of the bismuthinite-aikinite series (from krupkaite to bismuthinite) are predominant. A phase with the empirical formula CuPbBi7S12 was also identified and could potentially be a new bismuthinite derivative. The lillianite homologous series is represented by phases with composition between Gus73 and Gus59, with a dominance of members closer to gustavite (Gus97–79) and less abundant members closer to lillianite (Gus49). Native gold and Bi-sulfosalts are closely associated with the main sulfides (pyrrhotite, pyrite, chalcopyrite) and quartz, indicating simultaneous crystallization. Fluid inclusion data for quartz indicate a temperature interval between 205 and 247 °C. The assemblage within this vein was deposited from a low-salinity fluid (0.4–2.6 wt.% NaCl equiv.) and density from 0.80 to 0.87 g/cm3.
Optimization Model for Mine Backfill Scheduling Under Multi-Resource Constraints
Authors: Liu Yuhang , Li Guoqing , Hou Jie , Fan Chunchao , Tong Chuan , Wang Panzhi
Published: November 2024

Addressing the resource constraints, such as manpower and equipment, faced by mine backfilling operations, this study proposed an optimization model for backfill scheduling based on the Resource-Constrained Project Scheduling Problem (RCPSP). The model considered backfilling’s multi-process, multi-task, and multi-resource characteristics, aiming to minimize total delay time. Constraints included operational limits, resource requirements, and availability. The goal was to determine optimal resource configurations for each stope’s backfilling steps. A heuristic genetic algorithm (GA) was employed for solution. To handle equipment unavailability, a new encoding/decoding algorithm ensured resource availability and continuous operations. Case verification using real mine data highlights the advantages of the model, showing a 20.6% decrease in completion time, an 8 percentage point improvement in resource utilization, and a 47.4% reduction in overall backfilling delay time compared to traditional methods. This work provides a reference for backfilling scheduling in similar mines and promotes intelligent mining practices.
The Paleoproterozoic Raimunda Porphyry-Type Gold Deposit, Juruena Mineral Province, Amazonian Craton (Brazil): Constraints Based on Petrological, Fluid Inclusion and Stable Isotope Data
Authors: Lopes Adriana Araujo Castro , Moura Márcia Abrahão
Published: November 2024

The Juruena Mineral Province is an emerging world-class mineral province in the southern Amazonian Craton, due to numerous Au-Cu and base metal deposits, such as the Raimunda deposit, related to Novo Mundo 2.03–1.98 Ga I-type calc-alkaline granites. Its hydrothermal alteration zones comprise Na-metasomatism, microclinization, propylitic and sericitic alteration, silicification, a sulfide stage, and late carbonate alteration. The disseminated mineralization, associated with the sulfide stage, the main mineralization stage, is represented by gold inclusions and fracture-filling grains in pyrite, chalcopyrite, and Cu-Bi sulfides. Chlorite geothermometer and fluid inclusion data indicate temperature conditions of 325–380 °C for the mineralization. The coexistence of high-temperature aqueous and aqueous-carbonic fluid inclusions, based on a microthermometric study of fluid inclusions, reveals a mixing of medium-saline hot fluids with cooler and low-saline fluid. The δ18Ofluid (3.11–7.86‰) and δ34Spy data (−1.4–0.1‰) are coherent to the magmatic origin of the mineralizing fluid. Gold was initially transported as chlorine complexes in a hot, high-salinity, acidic, and oxidized fluid from the magma chamber, and later as H2S− complexes. The chemical-physical instability during fluid ascent is interpreted as a triggering factor for ore precipitation. The results offer valuable insights into the genesis of porphyry–Au deposits and their implications for prospecting in the Amazonian Craton.
(E)-2-Benzylidenecyclanones: Part XX—Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Unexpected Increased Reactivity of 4-Chromanone- Compared to 1-Tetralone Analogs in Thia-Michael Reactions
Authors: Bognár Gábor , Kenari Fatemeh , Pintér Zoltán , Borges Igor D. , Camargo Ademir J. , Oliveira Heibbe C. B. , Sanches-Neto Flávio Olimpio , Carvalho-Silva Valter H. , Napolitano Hamilton B. , Perjési Pál
Published: November 2024

In vitro relative cytotoxicity (IC50 (IIb)/IC50 (IIIb) of (E)-3-(4′-methylbenzylidene)-4-chromanone (IIIb) towards human Molt 4/C8 and CEM T-lymphocytes showed a >50-fold increase in comparison to those of the respective tetralone derivative (IIb). On the other hand, such an increase was not observed in the analogous 4-OCH3 (IIc and IIIc) derivatives. In order to study whether thiol reactivity—as a possible basis of the mechanism of action—correlates with the observed cytotoxicities, the kinetics of the non-enzyme catalyzed reactions with reduced glutathione (GSH) and N-acetylcysteine (NAC) of IIIb and IIIc were investigated. The reactivity of the compounds and the stereochemical outcome of the reactions were evaluated using high-pressure liquid chromatography-mass spectrometry (HPLC-MS). Molecular modeling calculations were performed to rationalize the unexpectedly higher thiol reactivity of the chromanones (III) compared to the carbocyclic analog tetralones (II). The results indicate the possible role of spontaneous thiol reactivity of compounds III in their recorded biological effects.
Detailed Studies on the Methoxylation and Subsequent Dealkylation of N,N-Diethylbenzenesulfonamide Using a Tailor-Made Electrosynthetic Reactor
Authors: Várda Ernák F. , Gyűjtő Imre , Ender Ferenc , Csekő Richárd , Balogh György T. , Volk Balázs
Published: November 2024

Benzenesulfonamides are an outstandingly important family of compounds in organic and medicinal chemistry. Herein, we report detailed studies on the electrochemical mono- and dideethylation of model compound N,N-diethylbenzenesulfonamide. In this context, all parameters of the electrosynthesis were systematically investigated, with a special emphasis on solvent screening and the effect of water on the outcome of the reaction. Beside a commercially available electrochemical reactor, a custom-made device has also successfully been designed and used in these transformations. Optimization of the reaction led to a green, scaled-up synthesis of the dealkylated products. Our experiments also render the synthesis and potential in situ use of the corresponding N-methoxyalkyl intermediate, a precursor of the reactive and versatile N-sulfonyliminium cation, possible.
Changes in the Composition, Antioxidant Activity, and Sensory Attributes of Olive Oil Used as a Storage Medium for Dried Tomato Preservation
Authors: Klisović Dora , Novoselić Anja , Brkić Bubola Karolina
Published: November 2024

The presence of food in extra virgin olive oil (EVOO) during simultaneous storage might bring additional changes to the oil’s composition and quality. To investigate this matter, the influence of dried tomatoes on the oxidative and hydrolytic parameters, fatty acids, phenolic and volatile composition, antioxidant activity, pigments, and sensory attributes of EVOO during six months of simultaneous storage at room temperature (RT; 22 ± 2 °C) and +4 °C, was studied. Lower storage temperature reduced the hydrolytic and oxidative degradation of oils when dried tomatoes were immersed. The dried tomatoes addition did not affect the fatty acids composition of EVOO. The accelerated degradation kinetics of individual phenolic compounds and antioxidant activity of oils were influenced by the presence of dried tomatoes, being more pronounced at RT. C6 and C5 volatiles responsible for the green odour of EVOO decreased, while tomato-derived volatiles (3-methylbutanal and acetic acid) increased during simultaneous storage with dried tomatoes, especially at RT. The addition of dried tomatoes diminished the intensities of EVOO’s positive attributes (fruitiness, bitterness, and pungency) while enhancing the tomato odour attribute. This study demonstrates that the introduction of dried tomatoes significantly alters the composition and quality of EVOO when used as a storage medium.
Changes in Morphological, Physiological and Phytochemical Traits of Different Dill (Anethum graveolens L.) Cultivars as Affected by Light-Emitting Diodes
Authors: Dehghani Nafiseh , Haghighi Maryam , Rahimmalek Mehdi , Sabzalian Mohammad R. , Szumny Antoni
Published: November 2024

Dill is a fragrant vegetable containing various beneficial compounds for health. This research aims to evaluate the impact of various spectra of LED light on essential oil composition and morphological and physiological characteristics of three dill cultivars. LED light treatments included greenhouse light as control (C), blue (B), red (R), red + blue (RB), and white (W). RB light enhanced most physiological indicators investigated in this study, including photosynthetic pigments, phenols, flavonoids, and antioxidant capacity. Furthermore, electrolyte leakage in the three cultivars of Khomein, Isfahan, and Varamin decreased when exposed to RB light compared with C light. Under RB light, the essential oil contained more dill ether and α-phellandrene than in other light conditions. In general, light treatment with 75% R light and 25% B light had a noticeable impact on enhancing physiological features compared with other light spectrums. α-phellandrene levels increased in the Isfahan and Varamin cultivars under RB and B light conditions. Finally, the RB light and Khomein cultivars improved physiological features, whereas RB and R light in the Varamin and Isfahan cultivars are recommended for more essential oil compositions in functional food production.
Expedient Synthesis of Substituted Thieno[3,2-b]thiophenes and Selenopheno[3,2-b]selenophenes Through Cascade Cyclization of Alkynyl Diol Derivatives
Authors: Feng Yingqi , Zhang Xuelin , He Ziqing , Zhao Miaoshan , Chen Lu , Li Yibiao , Luo Xiai
Published: November 2024

Thieno[3,2-b]thiophenes are used as key components in optoelectronic materials, porous hydrogen-storage hosts, organic solar cells, and polymer semiconductors. A step-efficient synthetic protocol was proposed herein for obtaining multisubstituted thieno[3,2-b]thiophene and selenopheno[3,2-b]selenophenes in moderate to good yields via the bisulfur/biselenium cyclization of alkynyl diols with I2/Na2S2O3 or selenium. Using this strategy, substitution patterns were obtained for backbone modification in functional materials.
Oligo(ethylene glycol) Methacrylate Copolymer-Modified Liposomes for Temperature-Responsive Drug Delivery System
Authors: Martinez Espinoza Maria Isabel , Gül Sezen , Mugnaini Luisa , Cellesi Francesco
Published: November 2024

A thermoresponsive copolymer based on oligo(ethylene glycol) methacrylate, Chol-P(MEO2MA-co-OEGMA), was synthesized using Atom Transfer Radical Polymerization (ATRP) and incorporated into thermosensitive liposomes (TSLs) for controlled drug release. The copolymer exhibited a lower critical solution temperature (LCST) of 37 °C, making it suitable for biomedical applications requiring precise thermal triggers. The copolymer was incorporated into various TSL formulations alongside phospholipids such as DPPC, Lyso-PC, HSPC, and DSPC. Physicochemical characterization of the liposomes, including average size, polydispersity index, loading efficiency (LE), and encapsulation efficiency (EE), was performed using dynamic light scattering and fluorescence spectroscopy. The results showed that the incorporation of the copolymer slightly affected particle size and decreased LE and EE in most formulations. Lyso-PC-containing formulations exhibited lower LE and EE, likely due to instability during purification. Albumin encapsulation demonstrated lower LE compared to the smaller carboxyfluorescein drug model, highlighting the influence of molecular weight on loading. Although copolymer-modified liposomes showed reduced loading capacity, they enhanced thermoresponsiveness in HSPC-based formulations. These findings suggest that incorporating thermoresponsive polymers into TSLs can optimize drug delivery systems for targeted, thermally triggered release.
Science Mapping of AI as an Educational Tool Exploring Digital Inequalities: A Sociological Perspective
Authors: Mac Fadden Isotta , García-Alonso Elena-María , López Meneses Eloy
Published: November 2024

This study aims to explore the evolution of the literature on the sociological implications of integrating artificial intelligence (AI) as an educational tool, particularly its influence on digital inequalities. While AI technologies, such as AI-based language models, have begun transforming educational practices by personalizing learning, fostering student autonomy, and supporting educators, concerns remain regarding access disparities, ethical implications, and the potential reinforcement of existing social inequalities. To address these issues, a bibliometric analysis employing science mapping was conducted on 1515 studies sourced from the Web of Science Core Collection. This analysis traces the thematic evolution of social science perspectives on AI’s role in education and its relationship with digital inequalities. The results indicate a growing academic interest in AI in education, with a notable progression from understanding its basic impact to exploring complex themes such as vulnerability, disability, bias, and community. The studies show that AI’s application has expanded from isolated research on specific populations to broader discussions on inclusivity, equity, and the impact of AI on governance, policy, and community. However, the findings also reveal a significant gap in sociological perspectives, particularly regarding issues like digital illiteracy and socio-economic access disparities. Although AI holds promise for promoting more inclusive education, further research is essential to address these sociological concerns and to guide the ethical, equitable implementation of AI as its influence on governance, policy, and community impact continues to grow.
Thermal Decomposition of Core–Shell-Structured RDX@AlH3, HMX@AlH3, and CL-20@AlH3 Nanoparticles: Reactive Molecular Dynamics Simulations
Authors: Sun Zijian , Yang Lei , Li Hui , Mei Mengyun , Ye Lixin , Fan Jiake , Zhu Weihua
Published: November 2024

The reactive molecular dynamics method was employed to examine the thermal decomposition process of aluminized hydride (AlH3) containing explosive nanoparticles with a core–shell structure under high temperature. The core was composed of the explosives RDX, HMX, and CL-20, while the shell was composed of AlH3. It was demonstrated that the CL-20@AlH3 NPs decomposed at a faster rate than the other NPs, and elevated temperatures could accelerate the initial decomposition of the explosive molecules. The incorporation of aluminized hydride shells did not change the initial decomposition mechanism of the three explosives. The yields of the main products (NO, NO2, N2, H2O, H2, and CO2) were investigated. There was a large number of solid aluminized clusters produced during the decomposition, mainly AlmOn and AlmCn clusters, together with AlmNn clusters dispersed in the AlmOn clusters.
Enhancing Photoelectrocatalytic Efficiency of BiVO4 Photoanodes by Crystal Orientation Control
Authors: Zhao Hongru , Wei Xinkong , Pei Yue , Han Weihua
Published: November 2024

Bismuth Vanadate (BiVO4) is a promising photoanode material due to its stability and suitable bandgap, making it effective for visible light absorption. However, its photoelectrocatalytic efficiency is often limited by the poor transport dynamics of photogenerated carriers. Recent research found that varying the atomic arrangement in crystals and Fermi levels across different crystal orientations can lead to significant differences in carrier mobility, charge recombination rates, and overall performance. In this work, we optimized the atomic arrangement by controlling the crystal growth direction to improve carrier separation efficiency using a wet chemical method. Systematic investigations revealed that the preferential [010]-oriented BiVO4 film exhibits the highest carrier mobility and photocurrent density. Under an applied bias of 1.21 V (vs. RHE) in a 0.5 M Na2SO4 electrolyte, it achieved a photocurrent density of 0.2 mA cm−2 under AM 1.5 G illumination, significantly higher than that of the [121]-oriented (0.056 mA cm−2) and randomly oriented films (0.11 mA cm−2). This study provides a deeper understanding of the role of crystal orientation in enhancing photoelectrocatalytic efficiency.
The Effectiveness and Safety of a Nutraceutical Combination in Overweight Patients with Metabolic Syndrome
Authors: Ricottini Lucilla , Basciani Sabrina , Spizzichini Maria , de Mattia Domenico , Coniglio-Iannuzzi delle Noci Manuela , Sorrentino Sasha , Nordio Maurizio
Published: November 2024

Background: The aim of the present study was to evaluate the effectiveness and safety of a nutraceutical combination given to insulin-resistant overweight patients with altered lipid profiles. To this end, an observational study was designed in which 74 individuals (50 females and 24 males) underwent an observational period of 3 months. Methods: During this time, a specific nutraceutical combination containing myo-inositol, glycine, Coprinus comatus, α-lipoic acid, phlorizin, zinc, vitamin B6, and chromium picolinate was administered. Patients were asked not to modify their lifestyles so that no variable that might interfere with results was introduced. Results: After the 3-month period, the obtained data revealed that insulin levels significantly decreased with respect to the baseline, while glucose levels exhibited a trend towards lower concentrations, which was not significant. In addition, HOMA-IR index, body weight, BMI, and abdominal circumference values all decreased significantly. Regarding lipid profiles, the data obtained before and after the 3-month period showed statistically significant decreases in concentrations of total cholesterol, LDL cholesterol, and triglyceride, as well as a small but statistically significant concomitant increase in HDL cholesterol. Conclusions: Thus, on the basis of these data, it may be stated that the specific nutraceutical combination used in the present study significantly ameliorated a number of metabolic parameters without measurable side effects. The efficacy and safety of the product were, therefore, confirmed in our group of patients.
Training and Nutrition for Performance: Males, Females, and Gender Differences
Authors: López Torres Olga , Fernández-Elías Valentín E.
Published: November 2024

As sports nutrition research evolves, a growing body of evidence highlights the importance of sex-based differences in responses to dietary interventions for athletic performance [...]