bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the Structure and Function of the Intestinal Flora in Rabbits Undergoing Hepatic Artery Infusion Chemotherapy
Authors: Yan Xiangdong , Bai Liuhui , Lv Jin , Qi Ping , Song Xiaojing , Zhang Lei
Published: May 2024

Few studies have explored the biological mechanism by which probiotics alleviate adverse reactions to chemotherapy drugs after local hepatic chemotherapy perfusion by regulating the intestinal flora. This study investigates the effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the intestinal microbial structure and intestinal barrier function, as well as the potential mechanism in rabbits after local hepatic chemotherapy infusion. Eighteen New Zealand White rabbits were randomly divided into a control group, a hepatic local chemotherapy perfusion group, and a hepatic local chemotherapy perfusion + Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets group to assess the effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the adverse reactions. The administration of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets alleviated the intestinal flora disorder caused by local hepatic perfusion chemotherapy, promoted the growth of beneficial bacteria, and inhibited the growth of harmful bacteria. The Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets also reduced the levels of serum pro-inflammatory cytokines and liver injury factors induced by local hepatic perfusion chemotherapy. Our findings indicate that Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets can ameliorate the toxicity and side effects of chemotherapy by regulating intestinal flora, blocking pro-inflammatory cytokines, reducing liver injury factors, and repairing the intestinal barrier. Probiotics may be used as a potential alternative therapeutic strategy to prevent the adverse reactions caused by chemotherapy with local hepatic perfusion.
Ethnic Aspects of Valproic Acid P-Oxidation
Authors: Shnayder Natalia A. , Grechkina Violetta V. , Trefilova Vera V. , Kissin Mikhail Ya. , Narodova Ekaterina A. , Petrova Marina M. , Al-Zamil Mustafa , Garganeeva Natalia P. , Nasyrova Regina F.
Published: May 2024

The safety of the use of psychotropic drugs, widely used in neurological and psychiatric practice, is an urgent problem in personalized medicine. This narrative review demonstrated the variability in allelic frequencies of low-functioning and non-functional single nucleotide variants in genes encoding key isoenzymes of valproic acid P-oxidation in the liver across different ethnic/racial groups. The sensitivity and specificity of pharmacogenetic testing panels for predicting the rate of metabolism of valproic acid by P-oxidation can be increased by prioritizing the inclusion of the most common risk allele characteristic of a particular population (country).
Enrichment of Bioactive Lipids in Urinary Extracellular Vesicles and Evidence of Apoptosis in Kidneys of Hypertensive Diabetic Cathepsin B Knockout Mice after Streptozotocin Treatment
Authors: Schramm Whitney C. , Bala Niharika , Arekar Tanmay , Malik Zeeshan , Chacko Kevin M. , Lewis Russell L. , Denslow Nancy D. , Scindia Yogesh , Alli Abdel A.
Published: May 2024

Cathepsin B (CtsB) is a ubiquitously expressed cysteine protease that plays important roles in health and disease. Urinary extracellular vesicles (uEVs) are released from cells associated with urinary organs. The antibiotic streptozotocin (STZ) is known to induce pancreatic islet beta cell destruction, diabetic nephropathy, and hypertension. We hypothesized that streptozotocin-induced diabetic kidney disease and hypertension result in the release of bioactive lipids from kidney cells that induce oxidative stress and renal cell death. Lipidomics was performed on uEVs isolated from CtsB knockout mice treated with or without STZ, and their kidneys were used to investigate changes in proteins associated with cell death. Lysophosphatidylethanolamine (LPE) (18:1), lysophosphatidylserine (LPS) (22:6), and lysophosphatidylglycerol (LPG) (22:5) were among the bioactive lipids enriched in uEVs from CtsB knockout mice treated with STZ compared to untreated CtsB mice (n = 3 uEV preparations per group). Anti-oxidant programming was activated in the kidneys of the CtsB knockout mice treated with STZ, as indicated by increased expression of glutathione peroxidase 4 (GPX4) and the cystine/glutamate antiporter SLC7A11 (XCT) (n = 4 mice per group), which was supported by a higher reactivity to 4-hydroxy-2-nonenal (4-HNE), a marker for oxidative stress (n = 3 mice per group). Apoptosis but not ferroptosis was the ongoing form of cell death in these kidneys as cleaved caspase-3 levels were significantly elevated in the STZ-treated CtsB knockout mice (n = 4 mice per group). There were no appreciable differences in the pro-ferroptosis enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4) or the inflammatory marker CD93 in the kidneys (n = 3 mice per group), which further supports apoptosis as the prevalent mechanism of pathology. These data suggest that STZ treatment leads to oxidative stress, inducing apoptotic injury in the kidneys during the development of diabetic kidney disease and hypertension.
Improved Multi-Strategy Sand Cat Swarm Optimization for Solving Global Optimization
Authors: Zhang Kuan , He Yirui , Wang Yuhang , Sun Changjian
Published: May 2024

The sand cat swarm optimization algorithm (SCSO) is a novel metaheuristic algorithm that has been proposed in recent years. The algorithm optimizes the search ability of individuals by mimicking the hunting behavior of sand cat groups in nature, thereby achieving robust optimization performance. It is characterized by few control parameters and simple operation. However, due to the lack of population diversity, SCSO is less efficient in solving complex problems and is prone to fall into local optimization. To address these shortcomings and refine the algorithm’s efficacy, an improved multi-strategy sand cat optimization algorithm (IMSCSO) is proposed in this paper. In IMSCSO, a roulette fitness–distance balancing strategy is used to select codes to replace random agents in the exploration phase and enhance the convergence performance of the algorithm. To bolster population diversity, a novel population perturbation strategy is introduced, aiming to facilitate the algorithm’s escape from local optima. Finally, a best–worst perturbation strategy is developed. The approach not only maintains diversity throughout the optimization process but also enhances the algorithm’s exploitation capabilities. To evaluate the performance of the proposed IMSCSO, we conducted experiments in the CEC 2017 test suite and compared IMSCSO with seven other algorithms. The results show that the IMSCSO proposed in this paper has better optimization performance.
Performance Analysis of the Structures Using Glass-Fiber-Reinforced-Polymer-Produced Hollow Internal Molds
Authors: Zhang Zhenhao , Yang Zanke , Li Hesheng , Yang Weijun
Published: May 2024

Hollow structures reduce weight without compromising load-bearing capacity and are widely used. The new Glass-Fiber-Reinforced Polymer high-strength thin-walled inner mold simplifies internal cavity construction and boosts structural performance. This study first investigates the influence of a GFRP high-strength thin-walled circular tube on the cross-sectional load-carrying capacity of hollow slabs. Then, a formula for the bending load-carrying capacity of the section under the action of the tube is derived. The results indicate that when the height of the concrete compression zone meets certain conditions, GFRP high-strength thin-walled circular tubes can improve the ultimate load-carrying capacity of the hollow floor slabs. In order to achieve a more economical design, the bending moment modification of a GFRP high-strength thin-walled circular tube of a continuous slab was studied. Research has found that the bending moment modulation limit for a continuous slab is 35.65% when it is subjected to a load of Pu=24 kN. Experimental analysis has shown that the results are generally consistent with the calculations. In practical engineering, the application of a GFRP high-strength thin-walled circular tube of continuous slabs has limitations. Therefore, this study investigated a GFRP high-strength thin-walled honeycomb core slab and found that its ultimate load-bearing capacity is greater compared to waffle slabs. In addition, the stress performance of the GFRP high-strength thin-walled honeycomb core internal mold is superior, making it more promising for practical applications.
Comprehensive Evaluation of Decarbonization Technologies: A Case Study of Residential Buildings in Zhuzhou City, China
Authors: Liu Jianlong , Tang Qing , Chen Haiyan , Meng Wenjing , Xu Feng , Li Zhisheng
Published: May 2024

Efficient carbon emission reduction technologies in buildings are necessary for achieving the “Dual carbon” goal in China. In this study, a comprehensive evaluation model is proposed to assess the effect of carbon emission reduction based on the analytic hierarchy process–entropy weight–coefficient of variation model which takes newly built residential buildings in Zhuzhou City as the research object. The results show that the preferred materials for the roof and exterior walls of the building’s envelope structure were flame-retardant extruded polystyrene boards, and porous shale bricks were preferred as the main materials for the exterior walls. In addition, the rooftop solar photovoltaic system and energy-saving air conditioning technology were suitable in terms of being renewable and were better utilized. In the end, carbon emissions were significantly reduced when using the building decarbonization technologies. This study provides a new reference for choosing materials and technologies for the design of residential buildings in Hunan Province and even other regions with hot summers and cold winters.
Experimental Study on Flexural Behavior of RC Piles with Basalt Fiber-Reinforced Polymer Bars and Load Carrying Capacity Calculation
Authors: Chen Jibin , Pan Qiang , Wei Yao , Luo Yibin
Published: May 2024

The practical application of BFRPB (Basalt Fiber-Reinforced Polymer Bars) as a support structure in foundation pit and slope engineering is relatively under-researched. The indoor tensile test presented in this paper is carried out on the bond between BFRPB and different labelled concrete. The mechanical characteristics of BFRPB, the failure characteristics, and the load-carrying capacity were analyzed. The results of this study demonstrate that the normal section stress of concrete cylindrical components with BFRP has a good linear relationship and supports the rationality of the flat section assumption. In circular reinforced concrete BFRP structures, the failure of the pile load occurs in four phases, and the cracking load is in the range of 51% to 67% of the normal yield load. The main bars increase in strain with load but become attenuated in the compression zone. The deformation of the main bars increases with the load but becomes muted in the compression zone. Based on the method of calculating the load-carrying capacity of GFRP-reinforced RC piles and the normal limit load-carrying moment obtained from in-door tests, the bending moment correction coefficient in the calculation formula for the load-carrying capacity of BFRP-reinforced RC piles was then obtained.
Waveform Complexity and Positioning Analysis of Acoustic Emission Events during the Compression Failure Process of a Rock Burst Prone Sample
Authors: Zhang Wenlong , Yu Jiajia , Xu Xiufeng , Ren Jianju , Liu Kaide , Shi Huifang
Published: May 2024

The localization results of acoustic emission (AE) events can reflect the location and pattern of burst-prone rock failures. However, event localization heavily depends on the quality of the original waveform of the sensor. Therefore, this study analyzed the AE waveform of a rock sample under compression to evaluate its failure localization and quality. From the research results, it could be seen that the initial failure was relatively calm, with clear take-off points, which can be better used for accurate AE event positioning. However, the later failure was severe, causing the take-off points of most sensors to be very unclear, and positioning methods that rely on take-off points cannot be used for positioning, let alone simply using the positioning results of the built-in software. This research result reminds researchers who use AE signals for event localization to first examine the quality and status of the original waveform, providing a basis for obtaining accurate localization results, in order to further accurately study the subsequent failure patterns. The above facts indicate that the initial failure is small and scattered, while the later failure is large and concentrated, with certain fractal characteristics.
Multi-Criteria Assessment of Timber-Based Structural Systems for a Grocery Store
Authors: Gecys Tomas , Tupenaite Laura , Kanapeckiene Loreta , Naimaviciene Jurga
Published: May 2024

To reduce the negative impact on the environment, architects, designers, and construction companies need to find and apply eco-friendly and sustainable building solutions. Due to its renewable nature and numerous advantages, timber has become an attractive substitute for steel and concrete in both residential and non-residential construction projects. However, timber application in the construction of grocery stores is a relatively new concept. The purpose of this research is to propose three alternative timber-based structural systems for a grocery store in Lithuania and to select the most efficient option based on multi-criteria decision-making methods. Three alternative glued laminated timber (glulam) structural systems—the glulam column and truss system, the glulam three-hinge frame system, and the glulam column and double-tapered beam system—were designed. The systems were evaluated against ten criteria, reflecting structural properties, cost efficiency, assembling complexity, and aesthetics. Multiple-criteria assessments by the COmplex PRoportional ASsessment (COPRAS) method and simple additive weighting (SAW) method revealed that the best-performing alternative is the glulam column and double-tapered beam system due to the lower cost of load-bearing structures, the smaller quantity of required steel details and fittings, and the highest maximum utility ratio according to serviceability limit states compared to other alternatives.
Metabolomics in Children Cow’s Milk Protein Allergy: Possible Contribution from a System Biology Approach?
Authors: Bosco Alice , Altea Veronica , Beretta Paola , Cacace Roberto , Fanos Vassilios , Dessì Angelica
Published: May 2024

One of the most frequent triggers of food anaphylaxis in pediatric age but also among the most common, early, and complex causes of childhood food allergy is cow’s milk protein allergy (CMPA). The diagnostic course and management of this allergy is defined in a complex clinical picture due to several factors. First of all, the epidemiological data are not uniform, mainly as a consequence of the diagnostic methodology used in the various studies and the different age ranges covered. In addition, there is the complexity of terminology, since although CMPA traditionally refers to immune-mediated reactions to cow’s milk, it is a term encompassing numerous clinical features with different symptoms and the requirement for specific treatments. Moreover, the differential diagnosis with other very frequent diseases, especially in the first year of life, such as gastro-esophageal reflux disease or colic, is still complex. This can result in misdiagnosis and incorrect treatment, with harmful health consequences and significant economic repercussions. In this context, the combination of several omics sciences together, which have already proved useful in clarifying the allergenicity of cow’s milk proteins with greater precision, could improve the diagnostic tests currently in use through the identification of new, more specific, and precise biomarkers that make it possible to improve diagnostic accuracy and predict the patient’s response to the various available treatments for the recovery of tolerance.
Trends in Amplitude-Integrated Electroencephalography in the Smallest Preterm Neonates
Authors: Štuikienė Kristina , Griesmaier Elke , Aldakauskienė Ilona , Vidmantė Regina , Šmigelskas Kastytis , Tamelienė Rasa
Published: May 2024

Background. Amplitude-integrated electroencephalography is increasingly used for the neuromonitoring of premature infants. However, it is still not clear how bioelectrical activity changes in the smallest gestational age newborns. The aim of our study was to evaluate the bioelectrical activity of amplitude-integrated electroencephalograms in premature newborns of different gestational age to assess how gestational age and postnatal age influence patterns of amplitude-integrated electroencephalograms and to test the hypothesis of whether the bioelectrical activity of the brain matures faster after the birth of premature newborns than in utero. Methods. We prospectively included infants born before 32 weeks of gestational age between June 2020 and July 2022. Serial recordings of amplitude-integrated electroencephalograms were performed at three time points of age (days 1–3, 13–15, and 27–29). Recordings were analyzed for background patterns, the onset and appearance of cyclicity, and lower amplitude border and bandwidth, which were used to derive a composite Burdjalov score. Results. In total, 140 premature neonates were included in the study, and 112 of them completed the study. The median gestational age of the newborns enrolled in the study was 29 (27–30) weeks, and the mean weight was 1206 (350) g. Burdjalov scores increased with increasing gestational age. Higher scores were observed in every dimension of the amplitude-integrated electroencephalograms for newborns of lower gestational age when compared to newborns of higher gestational age of the same postmenstrual age. There was a significant correlation between gestational age and parameters of amplitude-integrated electroencephalograms at all time points. Conclusions. A higher gestational age has a positive effect on the bioelectrical activity of amplitude-integrated electroencephalograms. Increasing postnatal age affected amplitude-integrated electroencephalograms more than gestational age. Our hypothesis that the bioelectrical activity of the brain matures faster for premature newborns after birth than in the womb was confirmed.
SCN1A—Characterization of the Gene’s Variants in the Polish Cohort of Patients with Dravet Syndrome: One Center Experience
Authors: Stawicka Elżbieta , Zielińska Anita , Górka-Skoczylas Paulina , Kanabus Karolina , Tataj Renata , Mazurczak Tomasz , Hoffman-Zacharska Dorota
Published: May 2024

The aim of this study was to characterize the genotype and phenotype heterogeneity of patients with SCN1A gene mutations in the Polish population, fulfilling the criteria for the diagnosis of Dravet syndrome (DRVT). Particularly important was the analysis of the clinical course, the type of epileptic seizures and the co-occurrence of additional features such as intellectual disability, autism or neurological symptoms such as ataxia or gait disturbances. Based on their results and the available literature, the authors discuss potential predictors for DRVT. Identifying these early symptoms has important clinical significance, affecting the course and disease prognosis. 50 patients of the Pediatric Neurology Clinic of the Institute of Mother and Child in Warsaw clinically diagnosed with DRVT and carriers of SCN1A pathogenic variants were included. Clinical data were retrospectively collected from caregivers and available medical records. Patients in the study group did not differ significantly in parameters such as type of first seizure and typical epileptic seizures from those described in other studies. The age of onset of the first epileptic seizure was 2–9 months. The co-occurrence of intellectual disability was confirmed in 71% of patients and autism in 18%. The study did not show a correlation between genotype and phenotype, considering the severity of the disease course, clinical symptoms, response to treatment, the presence of intellectual disability, autism symptoms or ataxia. From the clinical course, a significant problem was the differentiation between complex febrile convulsions and symptoms of DRVT. The authors suggest that parameters such as the age of the first seizure, less than one year of age, the onset of a seizure up to 72 h after vaccination and the presence of more than two features of complex febrile seizures are more typical of DRVT, which should translate into adequate diagnostic and clinical management. The substantial decrease in the age of genetic verification of the diagnosis, as well as the decline in the use of sodium channel inhibitors, underscores the growing attention of pediatric neurologists in Poland to the diagnosis of DRVT.
Tobacco Farmers’ Perceptions of Unsafe Tobacco Cultivation and Its Effect on Health and Environment: A Case of Chittagong Hill Tracts, Bangladesh
Authors: Mim Niamah Atya , Hasan Shaikh Shamim , Hoque Muhammad Ziaul , Ahmed Minhaz , Chakma Prabin
Published: May 2024

As the environment is severely harmed by tobacco (like growing, processing, production, and disposal), the study was set forth to determine the tobacco cultivation status and perceptions of the tobacco farmers toward the environmental and health hazards of tobacco farmers due to tobacco cultivation. We conducted the study in Lama Upazila, Bandarban Hill District, Bangladesh. The survey method was applied to collect the necessary data, utilizing a pre-structured interview schedule, from 242 tobacco farmers who were selected randomly. The study’s results portrayed that the average tobacco cultivation farming experience of the farmers was about 10 years, and the farmers occupied about 0.97 acres of land for cultivating tobacco, while 81% of the tobacco farmers utilized the plain lands for cultivating tobacco, although the study area was a hilly one. A huge amount of fuel wood (average 5390 kg) was required for the curing of tobacco leaves. The farmers produced about 2 MT of tobacco per year and earned about BDT 89,066 (USD 810) from this production. Given that 77% of the tobacco farmers in the research area felt that tobacco production increased the risks to the environment and tobacco farmers health, their opinions ranged from somewhat to highly favorable, which meant they were concerned about the environment and health hazards. The research’s findings provide useful background knowledge on the detrimental effects of Bangladesh’s tobacco farming.
Two Decades of Integrated Flood Management: Status, Barriers, and Strategies
Authors: Grigg Neil S.
Published: May 2024

Losses from flood disasters are increasing globally due to climate-driven forces and human factors such as migration and land use changes. The risks of such floods involve multiple factors and stakeholders, and frameworks for integrated approaches have attracted a global community of experts. The paper reviews the knowledge base for integrated flood risk management frameworks, including more than twenty bibliometric reviews of their elements. The knowledge base illustrates how integrated strategies for the reduction of flood risk are required at different scales and involve responses ranging from climate and weather studies to the construction of infrastructure, as well as collective action for community resilience. The Integrated Flood Management framework of the Associated Programme on Flood Management of the World Meteorological Organization was developed more than twenty years ago and is explained in some detail, including how it fits within the Integrated Water Resources Management concept that is managed by the Global Water Partnership. The paper reviews the alignment of the two approaches and how they can be used in tandem to reduce flood losses. Success of both integrated management approaches depends on governance and institutional capacity as well as technological advances. The knowledge base for flood risk management indicates how technologies are advancing, while more attention must be paid to social and environmental concerns, as well as government measures to increase participation, awareness, and preparedness. Ultimately, integrated flood management will involve solutions tailored for individual situations, and implementation may be slow, such that perseverance and political commitment will be needed.
Climate Risks and Stock Market Volatility over a Century in an Emerging Market Economy: The Case of South Africa
Authors: Wu Kejin , Karmakar Sayar , Gupta Rangan , Pierdzioch Christian
Published: May 2024

Because climate change broadcasts a large aggregate risk to the overall macroeconomy and the global financial system, we investigate how a temperature anomaly and/or its volatility affect the accuracy of forecasts of stock return volatility. To this end, we do not apply only the classical GARCH and GARCHX models, but rather we apply newly proposed model-free prediction methods, and use GARCH-NoVaS and GARCHX-NoVaS models to compute volatility predictions. These two models are based on a normalizing and variance-stabilizing transformation (NoVaS transformation) and are guided by a so-called model-free prediction principle. Applying the new models to data for South Africa, we find that climate-related information is helpful in forecasting stock return volatility. Moreover, the novel model-free prediction method can incorporate such exogenous information better than the classical GARCH approach, as revealed by the the squared prediction errors. More importantly, the forecast comparison test reveals that the advantage of applying exogenous information related to climate risks in prediction of the South African stock return volatility is significant over a century of monthly data (February 1910–February 2023). Our findings have important implications for academics, investors, and policymakers.
Optimizing Interhospital Transfers in Orthopedics and Trauma Surgery: Challenges, Insights, and Proposals for Standardized Care in Germany
Authors: Roos Jonas , Ben Amar Soufian , Weinhold Leonie , Zellner Alberto Alfieri , Touet Amadeo , Prangenberg Christian , Loy Thomas , Gathen Martin
Published: May 2024

Background: Germany’s high density of under-equipped hospitals and anticipated surge in orthopedic and trauma surgery-related diseases by 2030, combined with personnel shortages, are expected to increase patient transfers between hospitals, an issue that urgently needs standardized protocols. Despite some existing cooperative agreements, such as between joint-replacement centers or within the Trauma Network DGU®, these measures do not adequately address the full range of patient-transfer cases, including those due to a lack of specialization or staff shortages, resulting in delayed treatment and potential health risks. This study aims to dissect the intricacies of interhospital transfers in orthopedics and trauma surgery across Germany, focusing on understanding the underlying reasons for transfers, comparing the operational structures of small and large hospitals, and laying the groundwork for future standardized protocols to enhance patient care. Material and Methods: A cross-sectional study was conducted in the form of an online survey via SoSci Survey, which was directed at orthopedic surgeons and trauma surgeons working in hospitals in Germany. The 22-question survey gathered information on participants’ clinic roles, departmental details, transfer processes, frequent diagnoses, perceptions of transfer quality, and improvement areas. The survey was sent to orthopedic and trauma surgeons in Germany by the specialist society. The data were analyzed using descriptive and inferential statistics to ensure a comprehensive insight into interhospital transfer practices. Results: The study involved 152 participants from various hospital ranks and located in different hospital sizes and types across rural and urban areas. A significant difference was observed between the care structures of basic/regular care and central/maximum care hospitals, especially regarding the available facilities and specialties. These findings suggest improvements such as better patient documentation, increased digital communication, optimized patient distribution, and standardization of transfer requests, among others. Conclusions: This study highlights the urgent need for improved protocols and resource allocation to eliminate inequalities in transfers between hospitals in orthopedics and trauma surgery in Germany.
Surface Wear Monitoring System of Industrial Transformer Tap-Changer Contacts by Using Voice Signal
Authors: Tan Xiangyu , Zhou Fangrong , Li Wenyun , Ao Gang , Xu Xiaowei , Yang Le
Published: May 2024

Surface wear of the tap-changer contacts of industrial transformers (due to frequent switching times) easily leads to operation failure of industrial transformers, which affects the safety and stability of the transmission network. In this paper, an intelligent voice signal monitoring system was proposed for the abnormal condition (surface wear) of tap-changer contacts. This monitoring system was composed of a voice signal acquisition system, voice analysis system and voice processing system. First, the voice signal of the tap-changer contacts was collected, and the collected voice signal was analyzed in the time domain and the frequency domain. Secondly, the characteristic curve of the voice signal was proposed, and the voice curve was compared with that of the normal operation state. In this case, the running state and surface wear abnormal situation of the tap changer could be monitored and determined, and the cause of the abnormal state could also be further analyzed. This method solved the surface wear problem of the tap changer in industrial transformers, which could be not monitored effectively in real time. This method improved the operational reliability of industrial transformers and had high economic and social benefits.
New Data on the Reactions of Zirconium and Hafnium Tetrachlorides with Aliphatic Acids
Authors: Makhaev Victor D. , Petrova Larisa A. , Shilov Gennadii V. , Aldoshin Sergey M.
Published: May 2024

The reaction of ZrCl4 or HfCl4 with excess 2-methylpropanoic acid when boiling under reflux has been studied. The formation of polynuclear Zr and Hf complexes of the composition M2O(i-C3H7CO2)6 during prolonged reflux of the reaction mixtures was found. The complexes are very sensitive to hydrolysis, forming hexanuclear [M6(O)4(OH)4(i-C3H7CO2)12]. The reactions have a general character for aliphatic acids and can be used as an alternative to the known methods for the synthesis of polynuclear carboxylate clusters of Group 4 metals. The crystal and molecular structures of previously undescribed {[Hf6(μ3-O)4(μ3-OH)4(i-C3H7CO2)12(H2O)]·3i-C3H7COOH} have been determined. The molecular structure is a completely asymmetric hexanuclear cluster containing six Hf(IV) atoms united by a 4:4 μ3-O/OH system of bridges, and stabilized by twelve 2-methylpropanoate ligands, eight of which are bidentate bridging, three are chelating, and one is monodentate. The crystal structure of the complex includes three independent solvating 2-methylpropanoic acid molecules. The obtained IR spectroscopy data make it possible to determine the type of complexes in the reaction mixture. The results of the study may be useful for improving the catalytic systems for ethylene oligomerization.
Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications
Authors: Serra Mónica , Gudina Eduardo , Botelho Cláudia , Teixeira José António , Barros Ana Novo
Published: May 2024

Polyglutamic acid (PGA), a biopolymer comprising repeating units of glutamic acid, has garnered significant attention owing to its versatile applications. In recent years, microbial production processes have emerged as promising methods for the large-scale synthesis of PGA, offering advantages such as sustainability, efficiency, and tailored molecular properties. Beyond its industrial applications, PGA exhibits unique properties that render it an attractive candidate for use in the cosmetic industry. The biocompatibility, water solubility, and film-forming characteristics of PGA make it an ideal ingredient for cosmetic formulations. This article explores the extensive potential cosmetic applications of PGA, highlighting its multifaceted role in skincare, haircare, and various beauty products. From moisturizing formulations to depigmentating agents and sunscreen products, PGA offers a wide array of benefits. Its ability to deeply hydrate the skin and hair makes it an ideal ingredient for moisturizers, conditioners, and hydrating masks. Moreover, PGA’s depigmentating properties contribute to the reduction in hyperpigmentation and uneven skin tone, enhancing the overall complexion. As the demand for sustainable and bio-derived cosmetic ingredients escalates, comprehending the microbial production and cosmetic benefits of PGA becomes crucial for driving innovation in the cosmetic sector.
Synthesis and Characterization of Zinc Oxide Nanoparticle Anchored Carbon as Hybrid Adsorbent Materials for Effective Heavy Metals Uptake from Wastewater
Authors: Alanazi Abdullah G. , Habila Mohamed A. , ALOthman Zeid A. , Badjah-Hadj-Ahmed Ahmed-Yacine
Published: May 2024

Hybrid material-derived adsorbents have shown a great applicable efficiency in various fields, including industrial uses and environmental remediation. Herein, zinc oxide nanoparticle modified with carbon (ZnO-C) was fabricated and utilized for wastewater treatment through the adsorption of Zn(II), Cd(II), Co(II), and Mn(II). The surface and structural characteristics were examined using TEM, SEM, XRD, FTIR spectroscopy, EDS, and the BET surface area. Kinetics and equilibrium investigations were applied to optimize the adsorptive removal of Zn(II), Cd(II), Co(II), and Mn(II) onto ZnO-C. The results indicated that the formation of ZnO-C in crystalline sphere-like granules with a nano-size between 16 and 68 nm together with carbon matrix. In addition, the spherical granules of zinc oxide were gathered to form clusters. FTIR spectroscopy indicated that the ZnO-C surface was rich with OH groups and ZnO. The adsorption capacity 215, 213, 206, and 231 mg/g for Zn(II), Cd(II), Co(II), and Mn(II), respectively, at the optimal conditions pH between 5 and 6, a contact time of 180 min, and an adsorbent dose of 0.1 g/L. The adsorptive removal data modeling for the uptake of Zn(II), Cd(II), Co(II), and Mn(II) onto ZnO-C showed agreement with the assumption of the pseudo-second-order kinetic model and the Freundlich isotherm, suggesting a fast adsorption rate and a multilayered mechanism. The achieved adsorption capacity using the prepared ZnO-C was more effective compared to ZnO, carbon, Fe3O4, and Fe3O4-C. Real wastewater samples were applied, including valley water, industrial wastewater, and rain wastewater, and evaluated for the applicable uptake of Zn(II), Cd(II), Co(II), and Mn(II) using ZnO-C and Fe3O4-C with effective removal efficiency.
Two for One—Combined Morphologic and Quantitative Knee Joint MRI Using a Versatile Turbo Spin-Echo Platform
Authors: Lemainque Teresa , Pridöhl Nicola , Huppertz Marc , Post Manuel , Yüksel Can , Siepmann Robert , Radke Karl Ludger , Zhang Shuo , Yoneyama Masami , Prescher Andreas , Kuhl Christiane , Truhn Daniel , Nebelung Sven
Published: May 2024

Quantitative MRI techniques such as T2 and T1ρ mapping are beneficial in evaluating knee joint pathologies; however, long acquisition times limit their clinical adoption. MIXTURE (Multi-Interleaved X-prepared Turbo Spin-Echo with IntUitive RElaxometry) provides a versatile turbo spin-echo (TSE) platform for simultaneous morphologic and quantitative joint imaging. Two MIXTURE sequences were designed along clinical requirements: “MIX1”, combining proton density (PD)-weighted fat-saturated (FS) images and T2 mapping (acquisition time: 4:59 min), and “MIX2”, combining T1-weighted images and T1ρ mapping (6:38 min). MIXTURE sequences and their reference 2D and 3D TSE counterparts were acquired from ten human cadaveric knee joints at 3.0 T. Contrast, contrast-to-noise ratios, and coefficients of variation were comparatively evaluated using parametric tests. Clinical radiologists (n = 3) assessed diagnostic quality as a function of sequence and anatomic structure using five-point Likert scales and ordinal regression, with a significance level of α = 0.01. MIX1 and MIX2 had at least equal diagnostic quality compared to reference sequences of the same image weighting. Contrast, contrast-to-noise ratios, and coefficients of variation were largely similar for the PD-weighted FS and T1-weighted images. In clinically feasible scan times, MIXTURE sequences yield morphologic, TSE-based images of diagnostic quality and quantitative parameter maps with additional insights on soft tissue composition and ultrastructure.
Detection of Leak Areas in Vineyard Irrigation Systems Using UAV-Based Data
Authors: Pádua Luís , Marques Pedro , Dinis Lia-Tânia , Moutinho-Pereira José , Sousa Joaquim J. , Morais Raul , Peres Emanuel
Published: May 2024

Water is essential for maintaining plant health and optimal growth in agriculture. While some crops depend on irrigation, others can rely on rainfed water, depending on regional climatic conditions. This is exemplified by grapevines, which have specific water level requirements, and irrigation systems are needed. However, these systems can be susceptible to damage or leaks, which are not always easy to detect, requiring meticulous and time-consuming inspection. This study presents a methodology for identifying potential damage or leaks in vineyard irrigation systems using RGB and thermal infrared (TIR) imagery acquired by unmanned aerial vehicles (UAVs). The RGB imagery was used to distinguish between grapevine and non-grapevine pixels, enabling the division of TIR data into three raster products: temperature from grapevines, from non-grapevine areas, and from the entire evaluated vineyard plot. By analyzing the mean temperature values from equally spaced row sections, different threshold values were calculated to estimate and map potential leaks. These thresholds included the lower quintile value, the mean temperature minus the standard deviation (Tmean−σ), and the mean temperature minus two times the standard deviation (Tmean−2σ). The lower quintile threshold showed the best performance in identifying known leak areas and highlighting the closest rows that need inspection in the field. This approach presents a promising solution for inspecting vineyard irrigation systems. By using UAVs, larger areas can be covered on-demand, improving the efficiency and scope of the inspection process. This not only reduces water wastage in viticulture and eases grapevine water stress but also optimizes viticulture practices.
Automotive Parts Defect Detection Based on YOLOv7
Authors: Huang Hao , Zhu Kai
Published: May 2024

Various complex defects can occur on the surfaces of small automobile parts during manufacturing. Compared with other datasets, the auto parts defect dataset used in this paper has low detection accuracy due to various defects with large size differences, and traditional target detection algorithms have been proven to be ineffective, which often leads to missing detection or wrong identification. To address these issues, this paper introduces a defect detection algorithm based on YOLOv7. To enhance the detection of small objects and streamline the model, we incorporate the ECA attention mechanism into the network structure’s backbone. Considering the small sizes of defect targets on automotive parts and the complexity of their backgrounds, we redesign the neck portion of the model. This redesign includes the integration of the BiFPN feature fusion module to enhance feature fusion, with the aim of minimizing missed detections and false alarms. Additionally, we employ the Alpha-IoU loss function in the prediction phase to enhance the model’s accuracy, which is crucial for reducing false detection. The IoU loss function also boosts the model’s efficiency at converging. The evaluation of this model utilized the Northeastern University steel dataset and a proprietary dataset and demonstrated that the average accuracy (mAP) of the MBEA-YOLOv7 detection network was 76.2% and 94.1%, respectively. These figures represent improvements of 5.7% and 4.7% over the original YOLOv7 network. Moreover, the detection speed for individual images ranges between 1–2 ms. This enhancement in detection accuracy for small targets does not compromise detection speed, fulfilling the requirements for real-time, dynamic inspection of defects.
Investigation of Single-Event Effects for Space Applications: Instrumentation for In-Depth System Monitoring
Authors: Mattos André M. P. , Santos Douglas A. , Luza Lucas M. , Gupta Viyas , Dilillo Luigi
Published: May 2024

Ionizing radiation induces the degradation of electronic systems. For memory devices, this phenomenon is often observed as the corruption of the stored data and, in some cases, the occurrence of sudden increases in current consumption during the operation. In this work, we propose enhanced experimental instrumentation to perform in-depth Single-Event Effects (SEE) monitoring and analysis of electronic systems. In particular, we focus on the Single-Event Latch-up (SEL) phenomena in memory devices, in which current monitoring and control are required for testing. To expose the features and function of the proposed instrumentation, we present results for a case study of an SRAM memory that has been used on-board PROBA-V ESA satellite. For this study, we performed experimental campaigns in two different irradiation facilities with protons and heavy ions, demonstrating the instrumentation capabilities, such as synchronization, high sampling rate, fast response time, and flexibility. Using this instrumentation, we could report the cross section for the observed SEEs and further investigate their correlation with the observed current behavior. Notably, it allowed us to identify that 95% of Single-Event Functional Interrupts (SEFIs) were triggered during SEL events.
Enhancing Cryptographic Primitives through Dynamic Cost Function Optimization in Heuristic Search
Authors: Kuznetsov Oleksandr , Poluyanenko Nikolay , Frontoni Emanuele , Kandiy Sergey , Karpinski Mikolaj , Shevchuk Ruslan
Published: May 2024

The efficiency of heuristic search algorithms is a critical factor in the realm of cryptographic primitive construction, particularly in the generation of highly nonlinear bijective permutations, known as substitution boxes (S-boxes). The vast search space of 256! (256 factorial) permutations for 8-bit sequences poses a significant challenge in isolating S-boxes with optimal nonlinearity, a crucial property for enhancing the resilience of symmetric ciphers against cryptanalytic attacks. Existing approaches to this problem suffer from high computational costs and limited success rates, necessitating the development of more efficient and effective methods. This study introduces a novel approach that addresses these limitations by dynamically adjusting the cost function parameters within the hill-climbing heuristic search algorithm. By incorporating principles from dynamic programming, our methodology leverages feedback from previous iterations to adaptively refine the search trajectory, leading to a significant reduction in the number of iterations required to converge on optimal solutions. Through extensive comparative analyses with state-of-the-art techniques, we demonstrate that our approach achieves a remarkable 100% success rate in locating 8-bit bijective S-boxes with maximal nonlinearity, while requiring only 50,000 iterations on average—a substantial improvement over existing methods. The proposed dynamic parameter adaptation mechanism not only enhances the computational efficiency of the search process, but also showcases the potential for interdisciplinary collaboration between the fields of heuristic optimization and cryptography. The practical implications of our findings are significant, as the ability to efficiently generate highly nonlinear S-boxes directly contributes to the development of more secure and robust symmetric encryption systems. Furthermore, the dynamic parameter adaptation concept introduced in this study opens up new avenues for future research in the broader context of heuristic optimization and its applications across various domains.
Reducing Artisanal Fishery Impact on Marine Community: New Data from Comparison of Innovative and Traditional Gear
Authors: Madia Manfredi , Bottaro Massimiliano , Cillari Tiziana , Li Vorsi Andrea , Castriota Luca , Amico Maria Rita , Bizzarri Sergio , Maggio Teresa , Falautano Manuela , Gristina Michele , Di Lauro Ilaria , Trova Floriana , Perzia Patrizia , D’Ambra Roberto , Casola Enrico , Sinopoli Mauro
Published: May 2024

Fishery resources overexploitation, together with bycatch and discards, have an impact on marine ecosystems. The adoption of technologically innovative gears is a possible solution to reduce the discard and to enhance the sustainability of fishery, mainly in artisanal fisheries that represent about 80% of the EU Mediterranean fleet. In the perspective of fishery sustainability, it is necessary to study and test alternative gears to the traditional ones, also with collaboration of fishers. In the present study, results of experimental fishing activities carried out in two Mediterranean areas with traditional and innovative gears of small-scale fishing are reported. Thirty-four hauls were carried out to compare the catch of two types of trammel nets: a traditional one and experimental guarding net. Additionally, 12 hauls were carried out to compare collapsible pots and traditional pots. No significant differences were recorded between trammel nets in terms of commercial catch and discard. However, interesting differences in discard composition were recorded, with higher Elasmobranchs presence in trammel nets, including species assessed as critically endangered and vulnerable. The use of trapula pots in place of traditional ones showed a lower discard of specific resources and an advantage for fishers in terms of space occupied on board.
Antibacterial Activity and Action Mechanism of Bacteriocin Paracin wx7 as a Selective Biopreservative against Vancomycin-Resistant Enterococcus faecalis in Fresh-Cut Lettuce
Authors: Zhao Qian , Zhao Qingling , Li Jiabo , Yi Lanhua
Published: May 2024

Fresh-cut vegetables are widely consumed, but there is no food preservative available to selectively inhibit vancomycin-resistant E. faecalis, which is a serious health menace in fresh-cut vegetables. To develop a promising food biopreservative, a bacteriocin, paracin wx7, was synthesized, showing selective inhibition against E. faecalis with MIC values of 4–8 μM. It showed instant bactericidal mode within 1 h at high concentrations with concomitant cell lysis against vancomycin-resistant E. faecalis. Its lethal effect was visualized in a dose-dependent manner by PI/SYTO9 staining observation. The results of an in vivo control experiment carried out on E. faecalis in fresh-cut lettuce showed that 99.97% of vancomycin-resistant E. faecalis were dead after 64 μM paracin wx7 treatment for 7 days without influencing total bacteria. Further, the action mechanism of paracin wx7 was investigated. Confocal microscopy showed that paracin wx7 was located both on the cell envelope and in cytoplasm. For the cell envelope, the studies of membrane permeability using SYTOX Green dyeing and DNA leakage revealed that paracin wx7 damaged the membrane integrity of E. faecalis. Simultaneously, it exhibited membrane depolarization after analysis using DiSC3(5). Damage to the cell envelope resulted in cell deformation observed by scanning electron microscopy. On entering the cytoplasm, the paracin wx7 induced the production of endogenous reactive oxygen species.