bluuebunny/crossref_metadata_2025 huggingface dataset:
Participation in the International Judo Federation World Tour competitions and performance in Tokyo Olympic Games
Authors: Santos Danilo F. C. , Kons Rafael L. , Lopes-Silva João P. , Agostinho Marcus F. , Detanico Daniele , Takito Monica Y. , Franchini Emerson
Published: June 2023

Introduction

The International Judo Federation introduced a ranking system in 2009 that determines top athletes for the Olympic Games and seeds them in competitions. Previous research indicated that this ranking list and past performances predicted 19%–27% of performance in the Olympic Games and World Championships. However, due to the COVID-19 pandemic, the relationship between Judo World Tour competitions and Olympic Games performance may have been affected. This study aimed to examine the relationship between athletes' performance in Judo World Tour competitions and their competitive performance at the Olympic Games.

Methods

Data from 393 athletes who participated in the Tokyo Olympics were analyzed considering both long and short-term performance measures. Pearson correlation was used to determine the relationship between variables and multiple linear regressions were used to predict performance for each sex and the entire sample.

Results

The results revealed a range of magnitudes in the correlation between variables, varying from small to large. In terms of regression analyses, it was observed that, for females, the percentage of matches won during the classification period and competition in the year prior to the Olympic Games predicted 37% of their performance. For males, the percentage of matches won during the classification period and competition in the six months before the Olympic Games predicted 36% of their performance.

Discussion

Thus, athletes’ quality and reduced exposure to competition near the Olympic Games appear to be important factors in their performance at the event.
Unveiling the Power of Stochastic Methods: Advancements in Air Pollution Sensitivity Analysis of the Digital Twin
Authors: Todorov Venelin , Dimov Ivan
Published: June 2023

Thorough examination of various aspects related to the distribution of air pollutants in a specific region and the factors contributing to high concentrations is essential, as these elevated levels can be detrimental. To accomplish this, the development and improvement of a digital twin that encompasses all relevant physical processes in the atmosphere is necessary. This tool, known as DIGITAL AIR, has been created, and it is now necessary to extend it with precise sensitivity analysis. DIGITAL AIR is gaining popularity due to its effectiveness in addressing complex problems that arise in intricate environments; this motivates our further investigations. In this paper, we focus on the preparation and further investigation of DIGITAL AIR through sensitivity analysis with improved stochastic approaches for investigating high-level air pollutants. We discuss and test the utilization of this digital tool in tackling the issue. The unified Danish Eulerian model (UNI-DEM) plays a crucial role within DIGITAL AIR. This mathematical model, UNI-DEM, is highly versatile and can be applied to various studies concerning the adverse effects caused by elevated air pollution levels.
Transcriptional Landscape of 3D vs. 2D Ovarian Cancer Cell Models
Authors: Kerslake Rachel , Belay Birhanu , Panfilov Suzana , Hall Marcia , Kyrou Ioannis , Randeva Harpal S. , Hyttinen Jari , Karteris Emmanouil , Sisu Cristina
Published: June 2023

Three-dimensional (3D) cancer models are revolutionising research, allowing for the recapitulation of an in vivo-like response through the use of an in vitro system, which is more complex and physiologically relevant than traditional monolayer cultures. Cancers such as ovarian (OvCa) are prone to developing resistance, are often lethal, and stand to benefit greatly from the enhanced modelling emulated by 3D cultures. However, the current models often fall short of the predicted response, where reproducibility is limited owing to the lack of standardised methodology and established protocols. This meta-analysis aims to assess the current scope of 3D OvCa models and the differences in the genetic profiles presented by a vast array of 3D cultures. An analysis of the literature (Pubmed.gov) spanning 2012–2022 was used to identify studies with paired data of 3D and 2D monolayer counterparts in addition to RNA sequencing and microarray data. From the data, 19 cell lines were found to show differential regulation in their gene expression profiles depending on the bio-scaffold (i.e., agarose, collagen, or Matrigel) compared to 2D cell cultures. The top genes differentially expressed in 2D vs. 3D included C3, CXCL1, 2, and 8, IL1B, SLP1, FN1, IL6, DDIT4, PI3, LAMC2, CCL20, MMP1, IFI27, CFB, and ANGPTL4. The top enriched gene sets for 2D vs. 3D included IFN-α and IFN-γ response, TNF-α signalling, IL-6-JAK-STAT3 signalling, angiogenesis, hedgehog signalling, apoptosis, epithelial–mesenchymal transition, hypoxia, and inflammatory response. Our transversal comparison of numerous scaffolds allowed us to highlight the variability that can be induced by these scaffolds in the transcriptional landscape and identify key genes and biological processes that are hallmarks of cancer cells grown in 3D cultures. Future studies are needed to identify which is the most appropriate in vitro/preclinical model to study tumour microenvironments.
Frequency and Predictors of Dysplasia in Pseudopolyp-like Colorectal Lesions in Patients with Long-Standing Inflammatory Bowel Disease
Authors: De Cristofaro Elena , Lolli Elisabetta , Migliozzi Stefano , Sincovih Stella , Marafini Irene , Zorzi Francesca , Troncone Edoardo , Neri Benedetto , Biancone Livia , Del Vecchio Blanco Giovanna , Calabrese Emma , Monteleone Giovanni
Published: June 2023

Current endoscopic surveillance programs do not consider inflammatory bowel disease (IBD)-associated post-inflammatory polyps (pseudopolyps) per se clinically relevant, even though their presence seems to increase the risk of colorectal cancer (CRC). However, it remains unclear whether the link between pseudopolyps and CRC is indirect or whether some subsets of pseudopolyp-like lesions might eventually undergo neoplastic transformation. This study aimed to assess the frequency and predictors of dysplasia in pseudopolyp-like lesions in a population with long-standing colonic IBD. This was a retrospective, single-center study including patients with a colonic IBD (median disease duration of 192 months) and at least a pseudopolyp-like lesion biopsied or resected in the period from April 2021 to November 2022. One hundred and five pseudopolyps were identified in 105 patients (80 with ulcerative colitis and 25 with Crohn’s disease). Twenty-three out of 105 pseudopolyp samples (22%) had dysplastic foci, and half of the dysplastic lesions were hyperplastic. Multivariate analysis showed that the age of the patients (odds ratio (OR) 1.1; p = 0.0012), size (OR 1.39; p = 0.0005), and right colonic location (OR 5.32; p = 0.04) were independent predictors of dysplasia, while previous exposure to immunosuppressors/biologics and left colonic location of the lesions were inversely correlated to dysplasia (OR 0.11; p = 0.005, and OR 0.09; p = 0.0008, respectively). No differences were seen between ulcerative colitis and Crohn’s disease patients. Lesions with a size greater than 5 mm had a sensitivity of 87% and a specificity of 63% to be dysplastic. These data show that one-fourth of pseudopolyp-like lesions evident during surveillance colonoscopy in patients with longstanding IBD bear dysplastic foci and suggest treating such lesions properly.
Rethinking Iconic Species Reforestation in West Africa: Seed Shape Harnessing Is Strategic for Enhanced Germination and Vigorous Growth in Khaya senegalensis and Parkia biglobosa
Authors: Adji Beda Innocent , Letort Véronique , Wang Xiujuan , Kang Mengzhen , De Reffye Philippe , Jaeger Marc , Cilas Christian , Kouassi Kouadio Henri , Duminil Jérôme , Sabatier Sylvie , Akaffou Doffou Sélastique
Published: June 2023

Seed size is a critical factor that can impact the regeneration process of plant populations. The objective of this study is to identify optimal seeds for the cultivation of two overexploited native forest species in Côte d’Ivoire, namely Khaya senegalensis (Desr.) A.Juss., 1830 and Parkia biglobosa (Jacq.) R.BR. ex G. Don, 1830. A total of 1080 seeds per species were evaluated for germination and seedling vigour in two distinct environments (dry and humid) in Côte d’Ivoire. The results demonstrated that, for Khaya senegalensis, larger seeds exhibited higher germination rates, whereas for Parkia biglobosa, smaller and medium-sized seeds showed better germination performance. However, regardless of species and study site, larger seeds consistently produced more vigorous seedlings. In this case, pretreatment tests on large seeds of Parkia biglobosa can potentially enhance their germination performance. Large seeds, ranging from 0.25–0.37 g in Khaya senegalensis and 0.2–0.32 g in Parkia biglobosa, appear to be the most suitable and best candidates for high-quality, high-performance seeds to optimise the cultivation of these species in Côte d’Ivoire. Distributing such seeds to farmers can contribute to the success of reforestation and agroforestry programs involving these target species in Côte d’Ivoire. These findings contribute to the sustainable management of the target species and can serve as a basis for restructuring forest regeneration policies in Côte d’Ivoire.
Integrating Linguistic, Archaeological and Genetic Perspectives Unfold the Origin of Ugrians
Authors: Török Tibor
Published: June 2023

In the last year two publications shed new light on the linguistic and genomic history of ancient Uralic speakers. Here I show that these novel genetic and linguistic data are compatible with each-other and with the archaeological inferences, allowing us to formulate a very plausible hypothesis about the prehistory of Ugric speakers. Both genetic and archaeological data indicate the admixture of the Mezhovskaya population with northern forest hunters in the late Bronze Age, which gave rise to a “proto-Ugric” community. This finding is consistent with the linguistic reconstruction of the proto-Ugric language. Genetic data indicate an admixture of proto-Hungarians with early Sarmatians and early Huns, and I show that the first admixture can be reconciled with the formation of the Gorokhovo culture and its integration into the early Sarmatian Prokhorovka culture, while the second admixture corresponds to the transformation of the Sargat and Sarmatian cultures due to Xiongnu invasions.
Parents of Adolescents Who Experience Suicidal Phenomena—A Scoping Review of Their Experience
Authors: Rheinberger Demee , Shand Fiona , McGillivray Lauren , McCallum Sonia , Boydell Katherine
Published: June 2023

High prevalence rates of self-harm and suicide in adolescence provide unique challenges for parents. The aim of this scoping review was to explore key gaps in our understanding of the current scientific literature on the experience of parents who have adolescent children experiencing suicide crisis or self-harm. Four academic databases were searched using three broad concepts: self-harming behaviour or suicidal crisis; adolescents or young people; and the experiences or behaviour of parents, between journal inception and March 2022. Information reporting on the parents’ experience was extracted and a qualitative synthesis was conducted. Twenty-two articles met inclusion criteria and were assessed in detail. The experience of parents with an adolescent engaged in self-harm or suicidal crisis were classified into three temporal themes: discovery of the suicidal phenomena, management of suicidal phenomena, and after the suicidal phenomena had ceased. Parents caring for an adolescent experiencing self-harm or suicidal crisis experience poorer psychological wellbeing, difficulty accessing support services, and changes in the parent–child relationship. Parents desire greater support for both themselves and their child and further investigation is required to understand specifically which supports would be most appropriate at each stage.
Long COVID and Unemployment in Hawaii
Authors: Bonham Carl , Juarez Ruben , Siegal Nicole
Published: June 2023

The state of Hawaii has seen 390,000 COVID-19 cases and nearly 1900 deaths since the start of the pandemic. Although the negative impact of the pandemic on employment has been widely documented, this paper demonstrates that those who were infected and suffer from lingering symptoms (i.e., long COVID) had different employment outcomes than those who did not experience such symptoms. Using data from our longitudinal cohort in the state of Hawaii, we found that those who reported long COVID in May 2022 were 6.43% more likely to be unemployed at the time of the May survey and 7.07% more likely in November 2022. In addition, we showed that vaccination is associated with higher rates of employment; each additional vaccine an individual received by May decreased the likelihood of unemployment by 6.9% in May and 3.9% in November. Further, individuals who reported more severe symptoms of long COVID were 6.36% less likely to be employed in May and 5.75% less likely to be employed in November. Our results suggest that vaccination policies and policies aimed at preventing contraction and accommodating individuals with long COVID may be effective measures for mitigating the adverse effects of the pandemic on employment.
Special Issue: New Insight into the Molecular Role of Lipids and Lipoproteins in Vascular Diseases
Authors: Benitez Sonia , Sánchez-Quesada José Luis
Published: June 2023

Lipids and lipoproteins play a key role in cardiovascular diseases (CVD), mainly in the development of atherosclerosis [...]
A Mannose Receptor from Litopenaeus vannamei Involved in Innate Immunity by Pathogen Recognition and Inflammation Regulation
Authors: Guo Na , Liu Yuan , Hao Qiang , Sun Mingzhe , Li Fuhua
Published: June 2023

Mannose receptor, as a member of the C-type lectin superfamily, is a non-canonical pattern recognition receptor that can internalize pathogen-associated ligands and activate intracellular signaling. Here, a mannose receptor gene, LvMR, was identified from the Pacific white shrimp Litopenaeus vannamei. LvMR encoded a signal peptide, a fibronectin type II (FN II) domain, and two carbohydrate-recognition domains (CRDs) with special EPS and FND motifs. LvMR transcripts were mainly detected in the hepatopancreas, and presented a time-dependent response after pathogen challenge. The recombinant LvMR (rLvMR) could bind to various PAMPs and agglutinate microorganisms in a Ca2+-dependent manner with strong binding ability to D-mannose and N-acetyl sugars. The knockdown of LvMR enhanced the expression of most NF-κB pathway genes, inflammation and redox genes, while it had no obvious effect on the transcription of most phagocytosis genes. Moreover, the knockdown of LvMR caused an increase in reactive oxygen species (ROS) content and inducible nitric oxide synthase (iNOS) activity in the hepatopancreas after Vibrio parahaemolyticus infection. All these results indicate that LvMR might perform as a PRR in immune recognition and a negative regulator of inflammation during bacterial infection.
Molecular Network for Regulation of Seed Size in Plants
Authors: Zhang Jinghua , Zhang Xuan , Liu Xueman , Pai Qiaofeng , Wang Yahui , Wu Xiaolin
Published: June 2023

The size of seeds is particularly important for agricultural development, as it is a key trait that determines yield. It is controlled by the coordinated development of the integument, endosperm, and embryo. Large seeds are an important way of improving the ultimate “sink strength” of crops, providing more nutrients for early plant growth and showing certain tolerance to abiotic stresses. There are several pathways for regulating plant seed size, including the HAIKU (IKU) pathway, ubiquitin–proteasome pathway, G (Guanosine triphosphate) protein regulatory pathway, mitogen-activated protein kinase (MAPK) pathway, transcriptional regulators pathway, and phytohormone regulatory pathways including the auxin, brassinosteroid (BR), gibberellin (GA), jasmonic acid (JA), cytokinin (CK), Abscisic acid (ABA), and microRNA (miRNA) regulatory pathways. This article summarizes the seed size regulatory network and prospective ways of improving yield. We expect that it will provide a valuable reference to researchers in related fields.
Combining Solid and Liquid Biopsy for Therapy Monitoring in Esophageal Cancer
Authors: Richter Florian , Henssen Clara , Steiert Tim Alexander , Meissner Tobias , Mehdorn Anne-Sophie , Röcken Christoph , Franke Andre , Egberts Jan-Hendrik , Becker Thomas , Sebens Susanne , Forster Michael
Published: June 2023

Esophageal cancer (EC) has one of the highest mortality rates among cancers, making it imperative that therapies are optimized and dynamically adapted to individuals. In this regard, liquid biopsy is an increasingly important method for residual disease monitoring. However, conflicting detection rates (14% versus 60%) and varying cell-free circulating tumor DNA (ctDNA) levels (0.07% versus 0.5%) have been observed in previous studies. Here, we aim to resolve this discrepancy. For 19 EC patients, a complete set of cell-free DNA (cfDNA), formalin-fixed paraffin-embedded tumor tissue (TT) DNA and leukocyte DNA was sequenced (139 libraries). cfDNA was examined in biological duplicates and/or longitudinally, and TT DNA was examined in technical duplicates. In baseline cfDNA, mutations were detected in 12 out of 19 patients (63%); the median ctDNA level was 0.4%. Longitudinal ctDNA changes were consistent with clinical presentation. Considerable mutational diversity was observed in TT, with fewer mutations in cfDNA. The most recurrently mutated genes in TT were TP53, SMAD4, TSHZ3, and SETBP1, with SETBP1 being reported for the first time. ctDNA in blood can be used for therapy monitoring of EC patients. However, a combination of solid and liquid samples should be used to help guide individualized EC therapy.
Tissue-Specific Regulation of CFTR Gene Expression
Authors: Blotas Clara , Férec Claude , Moisan Stéphanie
Published: June 2023

More than 2000 variations are described within the CFTR (Cystic Fibrosis Transmembrane Regulator) gene and related to large clinical issues from cystic fibrosis to mono-organ diseases. Although these CFTR-associated diseases have been well documented, a large phenotype spectrum is observed and correlations between phenotypes and genotypes are still not well established. To address this issue, we present several regulatory elements that can modulate CFTR gene expression in a tissue-specific manner. Among them, cis-regulatory elements act through chromatin loopings and take part in three-dimensional structured organization. With tissue-specific transcription factors, they form chromatin modules and can regulate gene expression. Alterations of specific regulations can impact and modulate disease expressions. Understanding all those mechanisms highlights the need to expand research outside the gene to enhance our knowledge.
An Informed Decision Support Framework from a Strategic Perspective in the Health Sector
Authors: Alojail Mohammed , Alturki Mohanad , Bhatia Khan Surbhi
Published: June 2023

This paper introduces an informed decision support framework (IDSF) from a strategic perspective in the health sector, focusing on Saudi Arabia. The study addresses the existing challenges and gaps in decision-making processes within Saudi organizations, highlighting the need for proper systems and identifying the loopholes that hinder informed decision making. The research aims to answer two key research questions: (1) how do decision makers ensure the accuracy of their decisions? and (2) what is the proper process to govern and control decision outcomes? To achieve these objectives, the research adopts a qualitative research approach, including an intensive literature review and interviews with decision makers in the Saudi health sector. The proposed IDSF fills the gap in the existing literature by providing a comprehensive and adaptable framework for decision making in Saudi organizations. The framework encompasses structured, semi-structured, and unstructured decisions, ensuring a thorough approach to informed decision making. It emphasizes the importance of integrating non-digital sources of information into the decision-making process, as well as considering factors that impact decision quality and accuracy. The study’s methodology involves data collection through interviews with decision makers, as well as the use of visualization tools to present and evaluate the results. The analysis of the collected data highlights the deficiencies in current decision-making practices and supports the development of the IDSF. The research findings demonstrate that the proposed framework outperforms existing approaches, offering improved accuracy and efficiency in decision making. Overall, this research paper contributes to the state of the art by introducing a novel IDSF specifically designed for the Saudi health sector.
Additive Manufacturing Post-Processing Treatments, a Review with Emphasis on Mechanical Characteristics
Authors: Diniță Alin , Neacșa Adrian , Portoacă Alexandra Ileana , Tănase Maria , Ilinca Costin Nicolae , Ramadan Ibrahim Naim
Published: June 2023

Additive manufacturing (AM) comes in various types of technologies and comparing it with traditional fabrication methods provides the possibility of producing complex geometric parts directly from Computer-Aided Designs (CAD). Despite answering challenges such as poor workability and the need for tooling, the anisotropy of AM constructions is the most serious issue encountered by their application in industry. In order to enhance the microstructure and functional behavior of additively fabricated samples, post-processing treatments have gained extensive attention. The aim of this research is to provide critical, comprehensive, and objective methods, parameters and results’ synthesis for post-processing treatments applied to AM builds obtained by 3D printing technologies. Different conditions for post-processing treatments adapted to AM processes were explored in this review, and demonstrated efficiency and quality enhancement of parts. Therefore, the collected results show that mechanical characteristics (stress state, bending stress, impact strength, hardness, fatigue) have undergone significant improvements for 3D composite polymers, copper-enhanced and aluminum-enhanced polymers, shape memory alloys, high-entropy alloys, and stainless steels. However, for obtaining a better mechanical performance, the research papers analyzed revealed the crucial role of related physical characteristics: crystallinity, viscosity, processability, dynamic stability, reactivity, heat deflection temperature, and microstructural structure.
The Influence of Coherent Oxide Interfaces on the Behaviors of Helium (He) Ion Irradiated ODS W
Authors: Liu Xing , Dong Zhi , Shen Shangkun , Wang Yufei , Wu Zefeng , Hao Liyu , Du Jinlong , Zhang Jian , Ma Zongqing , Liu Yongchang , Fu Engang
Published: June 2023

Tungsten (W), as a promising plasma-facing material for fusion nuclear reactors, exhibits ductility reduction. Introducing high-density coherent nano-dispersoids into the W matrix is a highly efficient strategy to break the tradeoff of the strength–ductility performance. In this work, we performed helium (He) ion irradiation on coherent oxide-dispersoids strengthened (ODS) W to investigate the effect of coherent nanoparticle interfaces on the behavior of He bubbles. The results show that the diameter and density of He bubbles in ODS W are close to that in W at low dose of He ion irradiation. The radiation-induced hardening increment of ODS W, being 25% lower than that of pure W, suggests the involvement of the coherent interface in weakening He ion irradiation-induced hardening and emphasizes the potential of coherent nano-dispersoids in enhancing the radiation resistance of W-based materials.
Mechanical Properties and Deformation Mechanisms of Nanocrystalline U-10Mo Alloys by Molecular Dynamics Simulation
Authors: Ou Xuelian , Shen Yanxin , Yang Yue , You Zhenjiang , Wang Peng , Yang Yexin , Tian Xiaofeng
Published: June 2023

U-Mo alloys were considered to be the most promising candidates for high-density nuclear fuel. The uniaxial tensile behavior of nanocrystalline U-10Mo alloys with average grain sizes of 8–23 nm was systematically studied by molecular dynamics (MD) simulation, mainly focusing on the influence of average grain size on the mechanical properties and deformation mechanisms. The results show that Young’s modulus, yield strength and ultimate tensile strength follow as average grain size increases. During the deformation process, localized phase transitions were observed in samples. Grain boundary sliding and grain rotation, as well as twinning, dominated the deformation in the smaller and larger grain sizes samples, respectively. Increased grain size led to greater localized shear deformation, resulting in greater stress drop. Additionally, we elucidated the effects of temperature and strain rate on tensile behavior and found that lower temperatures and higher strain rates not only facilitated the twinning tendency but also favored the occurrence of phase transitions in samples. Results from this research could provide guidance for the design and optimization of U-10Mo alloys materials.
Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett’s Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations
Authors: Zaramella Alice , Arcidiacono Diletta , Nucci Daniele , Fabris Federico , Benna Clara , Pucciarelli Salvatore , Fassan Matteo , Fantin Alberto , De Re Vallì , Cannizzaro Renato , Realdon Stefano
Published: June 2023

Esophageal adenocarcinoma (EAC) is the consequence of longstanding gastroesophageal reflux, which leads to inflammation and could cause Barrett’s esophagus (BE), the main risk factor for EAC development. The 5 year survival rate of EAC is poor since the diagnosis occurs at the late stage of the disease. To improve patient management, a better comprehension of the mechanism undergoing the evolution through to adenocarcinoma is needed. Within this scenario, the resident microbiome investigation was studied. This study aimed to explore the esophageal microbial profile in patients affected by non-dysplastic BE, low- and high-grade dysplastic BE, and EAC to identify parameters characterizing cancer progression and to develop a score suitable for clinical practice to stratify cancer risk. The microbiota was investigated through the 16S rRNA gene sequencing of esophageal biopsies. The microbial composition was evaluated at each different taxonomic level along the disease progression. To further investigate bacteria potentially associated with cancer development, non-dysplastic and dysplastic/cancer patients were compared. The presence of the six significant microbial features with multivariate analysis was used to develop a multiparametric score (Resident Esophageal Microbial Dysbiosis Test) to predict the risk of progression toward EAC. Finally, the diagnostic ability of the test and its discrimination threshold for its ability to identify dysplastic/cancer patients were demonstrated. Since EAC has been related to obesity, the relationship between these microbial parameters and patients’ diet/lifestyle habits was also investigated. Developing microbiome-based risk prediction models for esophageal adenocarcinoma onset could open new research avenues, demonstrating that the resident microbiome may be a valid cancer risk biomarker.
The Involvement of Intestinal Tryptophan Metabolism in Inflammatory Bowel Disease Identified by a Meta-Analysis of the Transcriptome and a Systematic Review of the Metabolome
Authors: Wang Shan , van Schooten Frederik-Jan , Jin Han , Jonkers Daisy , Godschalk Roger
Published: June 2023

Evidence is emerging for the role of intestinal tryptophan metabolism in the development of inflammatory bowel disease (IBD). In order to identify the role of altered intestinal tryptophan metabolism in IBD pathogenesis, a meta-analysis of the transcriptome was performed to identify differentially expressed genes involved in the tryptophan metabolism pathways in intestinal biopsies of IBD as compared to non-IBD controls. Moreover, a systematic review of the metabolome was performed to identify the concurrent changes in tryptophan metabolites. Integration of the transcriptome and metabolome identified various alterations in intestinal tryptophan metabolism during active disease in IBD patients, including decreased intestinal tryptophan absorption, enhanced kynurenine pathway, increased interstitial serotonin availability, changed indole pathway, and activated aryl hydrocarbon receptor signaling. Therefore, a network of intestinal tryptophan metabolism pathways in IBD could be established, helping to assess the potential of genes and metabolites involved in these pathways as diagnostic markers and targets for IBD management.
A Review of Chitosan and Chitosan Nanofiber: Preparation, Characterization, and Its Potential Applications
Authors: Ibrahim Marwan A. , Alhalafi Mona H. , Emam El-Amir M. , Ibrahim Hassan , Mosaad Rehab M.
Published: June 2023

Chitosan is produced by deacetylating the abundant natural chitin polymer. It has been employed in a variety of applications due to its unique solubility as well as its chemical and biological properties. In addition to being biodegradable and biocompatible, it also possesses a lot of reactive amino side groups that allow for chemical modification and the creation of a wide range of useful derivatives. The physical and chemical characteristics of chitosan, as well as how it is used in the food, environmental, and medical industries, have all been covered in a number of academic publications. Chitosan offers a wide range of possibilities in environmentally friendly textile processes because of its superior absorption and biological characteristics. Chitosan has the ability to give textile fibers and fabrics antibacterial, antiviral, anti-odor, and other biological functions. One of the most well-known and frequently used methods to create nanofibers is electrospinning. This technique is adaptable and effective for creating continuous nanofibers. In the field of biomaterials, new materials include nanofibers made of chitosan. Numerous medications, including antibiotics, chemotherapeutic agents, proteins, and analgesics for inflammatory pain, have been successfully loaded onto electro-spun nanofibers, according to recent investigations. Chitosan nanofibers have several exceptional qualities that make them ideal for use in important pharmaceutical applications, such as tissue engineering, drug delivery systems, wound dressing, and enzyme immobilization. The preparation of chitosan nanofibers, followed by a discussion of the biocompatibility and degradation of chitosan nanofibers, followed by a description of how to load the drug into the nanofibers, are the first issues highlighted by this review of chitosan nanofibers in drug delivery applications. The main uses of chitosan nanofibers in drug delivery systems will be discussed last.
Studies on Polybenzimidazole and Methanesulfonate Protic-Ionic-Liquids-Based Composite Polymer Electrolyte Membranes
Authors: Anis Arfat , Alam Manawwer , Alhamidi Abdullah , Gupta Ravindra Kumar , Tariq Mohammad , Al-Zahrani Saeed M.
Published: June 2023

In the present work, different methanesulfonate-based protic ionic liquids (PILs) were synthesized and their structural characterization was performed using FTIR, 1H, and 13C NMR spectroscopy. Their thermal behavior and stability were studied using DSC and TGA, respectively, and EIS was used to study the ionic conductivity of these PILs. The PIL, which was diethanolammonium-methanesulfonate-based due to its compatibility with polybenzimidazole (PBI) to form composite membranes, was used to prepare proton-conducting polymer electrolyte membranes (PEMs) for prospective high-temperature fuel cell application. The prepared PEMs were further characterized using FTIR, DSC, TGA, SEM, and EIS. The FTIR results indicated good interaction among the PEM components and the DSC results suggested good miscibility and a plasticizing effect of the incorporated PIL in the PBI polymer matrix. All the PEMs showed good thermal stability and good proton conductivity for prospective high-temperature fuel cell application.
Revalorization of Coffee Residues: Advances in the Development of Eco-Friendly Biobased Potential Food Packaging
Authors: Hernández-Varela Josué D. , Medina Dora I.
Published: June 2023

One of the main limitations in the creation of bioplastics is their large-scale development, referred to as the industrial-scale processing of plastics. For this reason, bioplastic engineering emerges as one of the main objectives of researchers, who are attempting to create not only more environmentally friendly but also sustainable, low-cost, and less polluting materials. This review presents the advances in the development of biodegradable and compostable films/containers using eco-friendly components of by-products of the coffee industry, such as coffee flour (CF), coffee mucilage (CM), coffee husks (CH), coffee silverskin (CS), and spent coffee grounds (SCGs), and a brief review of the common industrial processing techniques for the production of food packaging, including extrusion, compression molding, injection molding, and laboratory-scale techniques such as solvent casting. Finally, this review presents various advances in the area that can be scalable or applicable to different products using by-products generated from the coffee industry, taking into account the limitations and drawbacks of using a biomaterial.
Structural and Theoretical Study of Copper(II)-5-fluoro Uracil Acetate Coordination Compounds: Single-Crystal to Single-Crystal Transformation as Possible Humidity Sensor
Authors: Vegas Verónica G. , García-Hernán Andrea , Aguilar-Galindo Fernando , Perles Josefina , Amo-Ochoa Pilar
Published: June 2023

This paper describes the synthesis and characterization of seven different copper(II) coordination compounds, as well as the formation of a protonated ligand involving all compounds from the same reaction. Their synthesis required hydrothermal conditions, causing the partial in situ transformation of 5-fluoro uracil-1-acetic acid (5-FUA) into an oxalate ion (ox), as well as the protonation of the 4,4′-bipyridine (bipy) ligand through a catalytic process resulting from the presence of Cu(II) within the reaction. These initial conditions allowed obtaining the new coordination compounds [Cu2(5-FUA)2(ox)(bipy)]n·2n H2O (CP2), [Cu(5-FUA)2(H2O)(bipy)]n·2n H2O (CP3), as well as the ionic pair [(H2bipy)+2 2NO3−] (1). The mother liquor evolved rapidly at room temperature and atmospheric pressure, due to the change in concentration of the initial reagents and the presence of the new chemical species generated in the reaction process, yielding CPs [Cu(5-FUA)2(bipy)]n·3.5n H2O, [Cu3(ox)3(bipy)4]n and [Cu(ox)(bipy)]n. The molecular compound [Cu(5-FUA)2(H2O)4]·4H2O (more thermodynamically stable) ended up in the mother liquor after filtration at longer reaction times at 25 °C and 1 atm., cohabiting in the medium with the other crystalline solids in different proportions. In addition, the evaporation of H2O caused the single-crystal to single-crystal transformation (SCSC) of [Cu(5-FUA)2(H2O)(bipy)]n·2n H2O (CP3) into [Cu(5-FUA)2(bipy)]n·2n H2O (CP4). A theoretical study was performed to analyze the thermodynamic stability of the phases. The observed SCSC transformation also involved a perceptible color change, highlighting this compound as a possible water sensor.
Triumfetta cordifolia Gum as a Promising Bio-Ingredient to Stabilize Emulsions with Potentials in Cosmetics
Authors: Fanwa Michèle N. , Malhiac Catherine , Hucher Nicolas , Cheumani Arnaud M. Y. , Ndikontar Maurice K. , Grisel Michel
Published: June 2023

The cosmetics industry is searching for efficient and sustainable substances capable of stabilizing emulsions or colloidal dispersions that are thermodynamically unstable because of their high surface energy. Therefore, surfactants are commonly used to stabilize the water/oil interface. However, the presence of a surfactant is not always sufficient to obtain stable emulsions on the one hand, and conventional surfactants are often subject to such controversies as their petroleum origin and environmental concerns on the other hand. As a consequence, among other challenges, it is obvious that research related to new—natural, biodegradable, biocompatible, available, competitive—surfactants are nowadays more intensive. This study aims to valorize a natural gum from Triumfetta cordifolia (T. cordifolia) as a sustainable emulsifier and stabilizer for oil-in-water (O/W) emulsions, and to evaluate how the nature of the fatty phase could affect this potential. To this end, O/W emulsions were prepared at room temperature using three different oils varying in composition, using a rotor–stator mixer. Resulting mixtures were characterized using optical microscopy, laser granulometry, rheology, pH and stability monitoring over time. The results demonstrated good potential for the gum as an emulsifying agent. T. cordifolia gum appears efficient even at very low concentrations (0.2% w/w) for the preparation and stabilization of the different O/W emulsions. The best results were observed for cocoglyceride oil due to its stronger effect of lowering interfacial tension (IFT) thus acting as a co-emulsifier. Therefore, overall results showed that T. cordifolia gum is undoubtedly a highly promising new bio-sourced and environmentally friendly emulsifier/stabilizer for many applications including cosmetics.
Protocols of Conversion: Indigenous Gods and Eminent Monks in East Asian Buddhism
Authors: Choe Jiyeon , Son Jin
Published: June 2023

This article examines the relationships between eminent monks and local gods in East Asian Buddhism, problematizing the ill-defined and much-employed concept of “protector deity of the dharma” (Skt. dharmapāla). By carefully examining various stories of the interactions between eminent monks and various gods found mostly in the biographies of eminent monks in Buddhist literature, we find three recognizable patterns when an indigenous god transforms into a “Buddhist” god. This study illustrates the ways in which local gods obtain Buddhist identities and deciphers how the “conversion” becomes possible via the spiritual power of the eminent monks, whose drive from their moral strength serves as the foundation of their spiritual essence. In this long process of localization of the dharma, the most effective narratives link the idea of the dharmapāla with the virtue of eminent monks. Hence, these narratives in GSZ, XGSZ, and Samugykusa contain colorful examples of taming local gods and malicious spirits with their mental power and moral virtue, finding a place for those gods to fit into the new Buddhist order. This study provides insights into the complex interactions between different religious traditions and sheds light on the ways in which religious ideas and practices are adapted and transformed in new cultural contexts.
Combating of Associated Issues for Sustainable Agri-Food Sectors
Authors: Mishra Debesh , Muduli Kamalakanta , Sevcik Lukas , Jana Sujoy Kumar , Ray Manidatta
Published: June 2023

Because of growing populations, more people living in cities, and higher incomes, the demand for food has changed in both quantity and quality. This has sped up the growth of different agricultural production and distribution chains. The necessary transition processes in the agri-food sectors, however, can often take a very long time to complete and have negative social and environmental effects, which puts the traditional development paradigm into question. This study looked at the trends affecting food systems in addition to the viability of sustainable development in Indian agriculture. In order to identify and then prioritize the related issues facing the agri-food sectors, this study comprised a thorough examination of the literature. Experts were consulted to rank the identified issues according to their degree of impact on the system with the use of an integrated “Best-Worst-Method (BWM)” and “Step-Wise Assessment and Ratio-Analysis (SWARA)” approach. The associated major issues were ranked using the BWM method, which revealed that “Issues with the lack of innovative systems” rated at the first level and was followed by “Issues with stability and availability of food; Issues of climate change and natural disasters; Food-governance-related issues; and Issues of accessing and utilizing food”, accordingly. The results of this study will help in developing appropriate intervention techniques at various service levels and in formulating policies, in addition to taking competent governments into consideration.
Chitin Oligosaccharide N,N′-Diacetylchitobiose (GlcNAc2) as Antimicrobial Coating against Listeria monocytogenes on Ready-to-Eat Shrimp
Authors: Zainal Abidin Munira , Kourmentza Konstantina , Niranjan Keshavan
Published: June 2023

N,N′-diacetylchitobiose, also known as GlcNAc2, is a chitin oligosaccharide and is reported to possess antimicrobial activity against pathogenic bacteria. In this study, 1% (w/v) GlcNAc2 solution was applied on ready-to-eat (RTE) shrimp and evaluated as an antimicrobial coating against Listeria monocytogenes during storage at 4 °C for 16 days. Texture properties, colour, TBARS values, moisture content and bacterial counts were monitored and analysed every four days. The results indicated that the GlcNAc2 coating retarded the changes in texture properties, TBARS values and moisture content of the RTE shrimp during storage. The presence of GlcNAc2 showed no significant changes in RTE shrimp colour in contrast to the control. However, the growth of L. monocytogenes inoculated on the GlcNAc2-coated RTE shrimp was slower than that of the control sample with the highest log reduction of 0.5 log CFU/mL being observed. This study showed that the GlcNAc2 used as an antimicrobial coating was able to inhibit the growth of L. monocytogenes, while maintaining the quality of the RTE shrimp during refrigerated storage.
How Does China Build Its Fintech Strategy? A Perspective of Policy Evolution
Authors: Yin Yingkai , Ma Hongxin , Wu Zhenni , Yue Aobo
Published: June 2023

Understanding the layout of China’s fintech policy planning from the perspective of policy science theory will help policy makers to fully understand the current development stage and evolutionary path of fintech and improve the implementation of fintech policies and the promotion of their effects. This study examines 120 fintech policies issued at the national level from 2017 to 2022; unifies policy tools, policy organizational structure, and policy effectiveness into a three-dimensional scientific policy analysis framework; and uses a text content mining method to provide a quantitative analysis of China’s current fintech policy system. In terms of the choice of policy tools, there is an unbalanced proportion, with environmental-type policy tools being overused and demand-type policy tools being underused; a network of core institutions for policy promulgation has been formed, with diversified types of subjects. However, overall, the degree of cooperation among various subjects is not high, and some departments closely related to the development of fintech are not involved enough in the publication of cooperation documents. Policy effectiveness depends on the number of policies and their average effectiveness, and the latter has insufficient growth momentum. Given the existing problems, some suggestions are made for optimising policies to develop fintech.
Exploring the Impact of Firm Transparency on Green Innovation Legitimacy: Empirical Evidence from Listed Companies in China
Authors: Xia Yuntian , Hou Junhao , Huang Hong , Liu Dongping , Ding Hongmei
Published: June 2023

Although the existing literature on innovation has little focus on information transparency, we aimed to determine how information transparency affects the legitimacy of green innovation in China. Accounting data, analyst data, and external audit data are used to evaluate a company’s information transparency. This paper examines the impact of corporate transparency on the legitimacy of green innovation in the context of three external information sources to which stakeholders have access, utilizing data from 4017 Chinese companies listed between 2005 and 2020. Our estimation results indicate a significant positive correlation between informational accessibility and green innovation legitimacy. The results demonstrate a stronger relationship between corporate green innovation legitimacy and greater earning quality, more analyst monitoring, more accurate analyst surplus estimations, and international audits by the Big Four. This study seeks to present new empirical findings for Chinese listed companies in order to strengthen the legality of green innovation and validate the significance of corporate information transparency via a robustness test.
Assessment of Machining of Hastelloy Using WEDM by a Multi-Objective Approach
Authors: Natarajan Manikandan , Pasupuleti Thejasree , Abdullah Mahmood M. S. , Mohammad Faruq , Giri Jayant , Chadge Rajkumar , Sunheriya Neeraj , Mahatme Chetan , Giri Pallavi , Soleiman Ahmed A.
Published: June 2023

Superalloys are a much-needed material for abundant engineering fields, such as nuclear-powered reactor components and aeronautics. Owing to their exceptional characteristics, such as higher thermal conductivity, they can be difficult to machine using conventional processes. Modern approaches to machining have evolved to utilize these materials. One of the techniques studied in this project is electrical discharge in a wire machine. This process can help to reduce the energy consumption during machining and negative impact on the environment. In addition, shortening the operation time of the machine can help to minimize its impact on the environment. The duration of the pulse and applied current are independent factors considered in this study. Material removal rate, surface roughness, dimensional deviation, and form/orientation tolerance errors are deemed as performance measures. The goal of this investigation is to reduce the time required to machine and improve the surface finish of components by implementing a Grey-based artificial neural network model. This method is useful in foretelling the conditions of the Wire Electro Discharge Machining (WEDM) process. This paper uses the Taguchi design and Analysis of Variance (ANOVA) framework to analyze the model’s variable inputs. The overall best coefficient of correlation (R = 0.9981) is fetched with an RMSE value of 0.0086. The material removal rate has been increased by decreasing the time taken for removal, which gives the possibility of consuming minimum energy. The finishing of the machined surface also improved. Moreover, this paper shows how to use an Artificial Neural Network (ANN) model with Grey Analysis. The results of the comparative analysis show that the values envisaged are closer with the actual values. The foretelling capacity of the evolved model is confirmed with the performance analysis of the developed model.