bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment of a comprehensive indicator to nondestructively analyze watermelon quality at different ripening stages
Authors: Qi Shuye , Song Shuhui , Jiang Shengnan , Chen Yingrui , Li Wu , Han Donghai
Published: August 2013

Two nondestructive methods based on visible and near-infrared (VIS-NIR) spectroscopy and X-ray image have been used for the evaluation of watermelon quality. The prediction performance based on partial least squares (PLS) by diffuse transmittance measurement (500–1010 nm) was evaluated for chemical quality attributes SSC (Rc = 0.903; RMSEC = 0.572% Brix; Rp = 0.862; RMSEP = 0.717% Brix; RPD = 1.83), lycopene (Rc = 0.845; RMSEC = 0.266 mg/100 gFW; Rp = 0.751; RMSEP = 0.439 mg/100 gFW; RPD = 1.13) and moisture (Rc = 0.917; RMSEC = 0.280%; Rp = 0.937; RMSEP = 0.276%; RPD = 2.79). The X-ray calibration linear equations developed by extracting the appropriate gray threshold were sufficiently precise for volume (R2 = 0.986) and weight (R2 = 0.993). In order to optimize prediction model of watermelon quality in growth period, multivariate multi-block technique factor analysis enabled integration of these traits: chemical information is related to physical information. Applying principle component analysis to extract common factors and varimax with Kaiser normalization to improve explanatory, the comprehensive indicator based on variances was established satisfactorily with Rc = 0.94, RMSEC = 0.244, Rp = 0.93, RMSEP = 0.344 and RPD = 2.00. A comparison of these models indicates that the comprehensive indicator determined only by portable VIS-NIR spectrometer appears as a suitable method for appraising watermelon quality nondestructively on the plant at different ripen stages. This method contributes to infer the picking date of watermelon with higher accuracy and bigger economic benefits than that by experience.
PREPARATION AND CHARACTERIZATION OF A NEAR-INFRARED LIGHT RESPONSIVE MICROCAPSULE SYSTEM FOR CANCER THERAPY
Authors: DI YINGFENG , CUI SISI , GU YUEQING
Published: August 2013

A novel near-infrared light responsive microcapsule system, gold nanorod-covered DOX-loaded hollow CaCO 3 microcapsule ( AuNR -HM-DOX) is developed for cancer therapy. The hollow CaCO 3 microcapsules were prepared based on the self-assembly between chitosan and sodium alginate on CaCO 3 particles via layer-by-layer technique, and then covered with gold nanorods to obtain the microcapsule system. Upon near-infrared (NIR) irradiation, microcapsule with gold nanorods can convert the absorbed NIR light into heat. Meanwhile, doxorubicin (DOX), a chemotherapy drug, is loaded into the microcapsule system via electrostatic adsorption for combined photothermal therapy and chemotherapy. Properties of AuNR -HM-DOX including grain diameter, optical spectra were characterized. Confocal fluorescence imaging was performed to observe the morphology of the capsules and existence of DOX in the core, confirming the successful loading of DOX. The release of DOX from the capsules under continuous NIR irradiation was investigated to evaluate the temperature responsiveness of AuNR -HM-DOX. Results indicate that AuNR -HM-DOX microcapsules possess uniform particle size and high light responsiveness. The combination of chemical and physical therapy of AuNR -HM-DOX features great potential as an adjuvant therapeutic alternative material for combined cancer therapy.
ROLLED-UP PERMALLOY NANOMEMBRANES WITH MULTIPLE WINDINGS
Authors: STREUBEL ROBERT , MAKAROV DENYS , LEE JEHYUN , MÜLLER CHRISTIAN , MELZER MICHAEL , SCHÄFER RUDOLF , BUFON CARLOS CESAR BOF , KIM SANG-KOOG , SCHMIDT OLIVER G.
Published: August 2013

We fabricated Permalloy ( Fe 19 Ni 81) nanomembranes rolled-up into compact three-dimensional architectures and experimentally investigated their magnetic and magneto-electric responses. When a magnetic nanomembrane is rolled-up, an additional magnetostatic interaction between the multiple windings emerges. Such kind of magnetostatic interaction, unique to the rolled-up magnetic nanomembranes and not accessible in any other magnetic architecture, is addressed for the first time in this study. An important feature of rolled-up tubes with multiple windings is that the inner and outer windings are formed by a single magnetic sheet; the spin configuration therefore must be continuous. The magnetostatic interaction induces anti-parallel alignment of the spins within adjacent layers of a rolled-up nanomembrane. The interplay between the magnetostatic interaction due to geometrical transformation and the exchange coupling in the film results in a stabilization of stripe domain patterns.
Overview of Recent and Holocene ostracods (Crustacea) from brackish and marine environments of Portugal
Authors: Cabral M. Cristina , Loureiro Isabel M.
Published: August 2013

Abstract. An extensive overview of Recent and Holocene ostracods from brackish and marine environments of Portugal is presented for the first time. 178 species belonging to 75 genera have been found and all are listed and illustrated with SEM images. From those species only 30 were found alive, most of them living in marginal-marine environments. Some comments on the 30 species found alive and a summary of main results are also presented. The data come from unpublished notes, reports of several research projects, observations on Recent ostracods in sediments from different estuaries of the western coast of Portugal and from the western Algarve continental shelf and slope, Masters theses and published papers.
New data on the stratigraphic distribution of the nannofossil genus Catinaster and on evolutionary relationships among its species
Authors: Ciummelli Marina , Raffi Isabella
Published: August 2013

Abstract. Examination of Upper Miocene–Lower Pliocene sediments at IODP Site U1338, in the Eastern Equatorial Pacific, provided new data on the distribution range of the calcareous nannofossil genus Catinaster. In addition to the the well-known occurrence of Catinaster coalitus and Catinaster calyculus in the early Late Miocene, we document Catinaster mexicanus in both the mid-late Miocene and the Early Pliocene. We confirm its taxonomic validity, rejecting previous interpretations of Pliocene C. mexicanus specimens as the result of dissolution of Discoaster altus. Instead, the Pliocene appearance of C. mexicanus seems to originate from the D. altus lineage. The short interval of occurrence (c. 50 ka) in the Late Miocene may document a preliminary evolutionary emergence of C. mexicanus that lacks any relationship with the other Catinaster species. Clear ancestor species to validate its independent origin from Discoaster are, however, missing. In the stratigraphic intervals where Catinaster species are found, their co-occurrence with Discoaster species bearing a prominent star-shaped boss on one side is noteworthy. This suggests that Catinaster and Discoaster at times developed a common morphological feature (a stellate structure, with or without hexaradiate symmetry), possibly under recurrent changes in climatic/environmental conditions. The data presented on C. mexicanus suggest a wider geographical distribution than previously thought, extending from the tropical Pacific to the Gulf of Mexico, equatorial Atlantic and tropical Indian oceans.
A fungal proliferation near the probable Oligocene/Miocene boundary, Nukhul Formation, Gulf of Suez, Egypt
Authors: El Atfy Haytham , Brocke Rainer , Uhl Dieter
Published: August 2013

Abstract. Moderately to well-preserved palynomorph assemblages were recorded from thirty samples of the Nukhul Formation (GH 404-2A Well), southern Gulf of Suez, Egypt. The taxa are dominated by highly diverse fungi, freshwater algae (e.g. Botryococcus, Pediastrum) beside a sparse record of spores and pollen. Marine palynomorphs, such as dinoflagellate cysts (dinocysts), are very rare. The stratigraphy and age of the Nukhul Formation is highly debated due to lack of diagnostic fossils (e.g. foraminifera, nannoplankton). It has been referred mostly to the Early Miocene; however, some recent publications interpret it as being of latest Oligocene–Early Miocene age. A prominent fungal proliferation composed of diverse and moderately well-preserved fungal spores, fungal fragments, fructifications and hyphae is recorded. This fungi-rich interval occurs mainly from 11370 to 11430 ft in the GH 404-2A Well. Such an observation has not been noted previously within the Nukhul Formation or its stratigraphic equivalents in Egypt. This putative ‘eco-event’ is probably associated with the well-known eustatic sea-level fall in the latest Chattian to early Aquitanian or at the Oligocene/Miocene boundary (OMB). It also seems possible that it may represent a more local event related to the rifting of the Gulf of Suez during this period. The high diversity of fossil fungi is interpreted herein as an indication of an episodic prevalence of humid climate at the end of a regressive phase, as also indicated by a lithological change near the top of the Shoab Ali Member of the Nukhul Formation. In addition, the co-occurrence of freshwater algae, mainly Botryococcus and Pediastrum, together with some aquatic fungal genera, such as Involutisporonites, Paragrantisporites, Quilonia, Striadiporites and Reduviasporonites, suggests the temporary existence of shallow, pond- or lake-like aquatic habitats, possibly related to tectonic activity.
Methods and Models for Costing Carbon Mitigation
Authors: Sathaye Jayant , Shukla P.R.
Published: August 2013

Using the results of more than 20 different global models with a particular emphasis on two rapidly growing large countries (China and India), this paper discusses the cost estimation methods that are used in setting up information for organizing models and to illustrate their global applicability to China, Korea, Japan, India, Indonesia, Europe, Latin America, the Middle East, Africa, and the United States. Some clear points emerge from the intermodal comparison exercise. First, no single technology can play a leading role in global emission mitigation. Second, although participation of all the regions is important, regions where future demographic and economic growth is concentrated will share a large part of this burden. Third, different technologies are important for different regions for mitigating emissions in the most cost-effective way. Fourth, if stringent climate policy targets are to be met, then emission-reduction actions need to be undertaken as soon as possible.
A Review of Merton’s Model of the Firm’s Capital Structure with Its Wide Applications
Authors: Sundaresan Suresh
Published: August 2013

Since its publication, the seminal structural model of default by Merton (1974) has become the workhorse for gaining insights about how firms choose their capital structure, a “bread and butter” topic for financial economists. Capital structure theory is inevitably linked to several important empirical issues such as (a) the term structure of credit spreads, (b) the level of credit spreads implied by structural models in relation to the ones that we observe in the data, (c) the cross-sectional variations in leverage ratios, (d) the types of defaults and renegotiations that one observes in real life, (e) the manner in which investment and financial structure decisions interact, (f) the link between corporate liquidity and corporate capital structure, (g) the design of capital structure of banks [contingent capital (CC)], (h) linkages between business cycles and capital structure, etc. The literature, building on Merton’s insights, has attempted to tackle these issues by significantly enhancing the original framework proposed in his model to make the theoretical framework richer (by modeling frictions such as agency costs, moral hazard, bankruptcy codes, renegotiations, investments, state of the macroeconomy, etc.) and in greater accordance with stylized facts. In this review, I summarize these developments.
Law and Finance: The Case of Constructive Sales
Authors: Brennan Thomas J.
Published: August 2013

This review illustrates the interaction between law and finance in the particular case of the taxation of constructive sales. The focus is on the treatment of variable prepaid forward contracts and the rules regarding these instruments articulated by Revenue Ruling 2003-7 and the recent case involving Philip Anschutz ( Anschutz Co. et al. v. Commissioner of Internal Revenue 2011 ). Simple models are used to show how the tests established by the law fail to reflect important financial considerations, such as the volatility of asset returns and the riskiness of dividend payments. These models provide examples that form the basis for a critique of the current rules and also indicate a possible path for future reform and improvement of the law, namely the addition of a delta-based test to the existing rules. The analysis presented here aims to encourage future work that applies financial theory to critique and improve legal rules in a wide range of other situations.
Numerical Simulations of Flows with Moving Contact Lines
Authors: Sui Yi , Ding Hang , Spelt Peter D.M.
Published: August 2013

Computational methods have been extended recently to allow for the presence of moving contact lines in simulated two-phase flows. The predictive capability offered by these methods is potentially large, joining theoretical and experimental methods. Several challenges rather unique to this area need to be overcome, however, notably regarding the conditions near a moving contact line and the very large separation of length scales in these flows. We first summarize the main models for moving contact lines and follow with an overview of computational methods that includes direct continuum approaches and macroscale models that resolve only the large-scale flow by modeling the effects of the conditions near the contact line using theory. Results are presented for contact-line motion on ideal as well as patterned and grooved surfaces and for extensions to account for complexities such as thermocapillarity and phase change.
Contemporary Sediment-Transport Processes in Submarine Canyons
Authors: Puig Pere , Palanques Albert , Martín Jacobo
Published: August 2013

Submarine canyons are morphological incisions into continental margins that act as major conduits of sediment from shallow- to deep-sea regions. However, the exact mechanisms involved in sediment transfer within submarine canyons are still a subject of investigation. Several studies have provided direct information about contemporary sedimentary processes in submarine canyons that suggests different modes of transport and various triggering mechanisms. Storm-induced turbidity currents and enhanced off-shelf advection, hyperpycnal flows and failures of recently deposited fluvial sediments, dense shelf-water cascading, canyon-flank failures, and trawling-induced resuspension largely dominate present-day sediment transfer through canyons. Additionally, internal waves periodically resuspend ephemeral deposits within canyons and contribute to dispersing particles or retaining and accumulating them in specific regions. These transport processes commonly deposit sediments in the upper- and middle-canyon reaches for decades or centuries before being completely or partially flushed farther down-canyon by large sediment failures.
Low-Energy e+e− Hadronic Annihilation Cross Sections
Authors: Davier Michel
Published: August 2013

The past decade has seen very significant progress in the measurement of the cross section for the annihilation process e+e−→hadrons. Different experimental approaches have helped achieve a more complete and fairly consistent picture. I provide a short review of the procedures used to obtain a continuous description of cross sections combining all available results from experiments. These data are necessary input to calculations of hadronic vacuum polarization effects that use dispersion integrals in an energy regime in which perturbative QCD cannot be applied. Applications include the hadronic contribution to the muon magnetic anomaly prediction in the Standard Model and the running of the electromagnetic coupling through the scale dependence of α(s), particularly its value at the Z boson mass, which is necessary for electroweak precision tests. Another application is for QCD studies that aim to accurately determine the strong coupling and its running, αS(s), and the heavy quark masses.
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
Authors: Semenza Gregg L.
Published: August 2013

Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory system and in cancer. The role of HIFs in these diseases has been elucidated by clinical studies and by analyses of mouse models. HIFs play a protective role in the pathophysiology of myocardial ischemia due to coronary artery disease, limb ischemia due to peripheral arterial disease, pressure-overload heart failure, wound healing, and chronic rejection of organ transplants. In contrast, HIFs contribute to the pathogenesis of pulmonary arterial hypertension, systemic hypertension associated with sleep apnea, ocular neovascularization, hereditary erythrocytosis, and cancer.
The Epidemiological Boehringer Ingelheim Employee Study—Part I: Impact of Overweight and Obesity on Cardiometabolic Risk
Authors: Kempf Kerstin , Martin Stephan , Döhring Carmen , Dugi Klaus , Wolfram von Wolmar Carolin , Haastert Burkhard , Schneider Michael
Published: August 2013

Objective.Obesity-dependent diseases cause economic burden to companies. Large-scale data for working populations are lacking. Prevalence of overweight and obesity in the Boehringer Ingelheim (BI) Employee cohort and the relationship between body mass index (BMI) and cardiometabolic risk factors and diseases were estimated.Design and Methods.Employees (≥38 years, employed in Ingelheim ≥2 years;n=3151) of BI Pharma GmbH & Co. KG were invited by the medical corporate department to participate in intensive health checkups. Cross-sectional analysis of baseline data collected through 2006–2011 was performed.Results.90% of eligible subjects participated (n=2849). Prevalences of overweight and obesity were 40% and 18% and significantly higher in men and participants ≥50 years. Cardiometabolic risk factor levels and prevalences of cardiometabolic diseases significantly increased with BMI and were higher in overweight and obese participants. Cut-points for increased risk estimated from ROC curves were≈25 kg/m2for hypertension, hypercholesterolemia, arteriosclerosis, and hypertriglyceridemia and 26.7–28.0 kg/m2for the metabolic syndrome, insulin resistance, hyperinsulinemia, increased intima media thickness, and type 2 diabetes.Conclusion.This is the first large-scale occupational health care cohort from a single company. Cardiometabolic risk factors and diseases accumulate with increasing BMI. Occupational weight reduction programs seem to be reasonable strategies.
VEGFandbFGFGene Polymorphisms in Patients with Non-Hodgkin's Lymphoma
Authors: Wróbel Tomasz , Mazur Grzegorz , Dzietczenia Justyna , Gębura Katarzyna , Kuliczkowski Kazimierz , Bogunia-Kubik Katarzyna
Published: August 2013

Angiogenesis and lymphangiogenesis are important in the proliferation and survival of the malignant hematopoietic neoplasms, including non-Hodgkin’s lymphomas (NHLs). Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in the initiation of angiogenesis. Both VEGF and bFGF have been reported to have prognostic significance in NHL. The present study aimed to determine an association between theVEGFandbFGFgene polymorphisms and disease susceptibility and progression.VEGF(rs3025039; 936 C>T) andbFGF(rs308395, −921 G>C) variants were determined in 78 NHL patients and 122 healthy individuals by PCR-RFLP technique. The presence of theVEGF 936Tallele was found to significantly associate with worse prognosis of the disease (expressed by the highest International Prognostic Index (IPI)) (0.41 versus 0.20, for IPI 4 among patients having and lacking theTallele). TheVEGF 936Tvariant was also more frequent among patients with IPI 4 than in controls (OR = 3.37, ). ThebFGF −921Gvariant was more frequently detected among patients with aggressive as compared to those with indolent histological subtype (0.37 versus 0.18, ) and healthy individuals (0.37 versus 0.19, OR = 2.51, ). These results imply that VEGF and bFGF gene polymorphisms have prognostic significance in patients with NHL.
The Influence of Emulsifier on Rheological and Sensory Properties of Cosmetic Lotions
Authors: Moravkova Tereza , Filip Petr
Published: August 2013

Three body lotions (water-in-oil type) differing only in the emulsifier content were subjected to rheological measurements and sensory analysis with the aim to obtain coupling between the selected rheological characteristics and sensory factors. Both methods proved different behaviour of the samples caused by the difference in the emulsifying compound. To detect the relations between rheological (application of the power law model) and sensory variables, the four most important characteristics from sensory assessment (ease of pouring from the bottle, ease of spreading on a palm, thickness, and ease of spreading on back of hand) were selected. A close coupling (and hence mutual substitution) was found between consistency parameterkand thickness,kand the ease of pouring from the bottle, and alsokand the mean droplet size.
Cross-Reactivity againstNaja sumatrana(Black Spitting Cobra) Envenoming from the Haffkine Antivenom in a Mouse Model
Authors: Cham Gregory , Lim Francis , Earnest Arul , Gopalakrishnakone Ponnampalam
Published: August 2013

Naja sumatranais the dominant cobra species in Malaysia, Singapore, Borneo, and Sumatra, and it does not have specific antivenom. The Haffkine antivenom has been advocated instead. This study aims to determine the efficacy of this antivenom againstNaja sumatranaenvenoming using a mouse model.Methods. Male Swiss albino mice were used. Intravenous LD50was first determined separately forNaja najaandNaja sumatranavenom. ED50was determined by preincubating antivenom with each venom at 2.5 LD50before administering the mixture into the tail vein. Validation was carried out using a challenge test. Each mouse received 111 µg ofNaja sumatranavenom intramuscularly followed by intraperitoneal administration of dilute Haffkine antivenom. Survival was recorded 24 hours after envenoming.Results. The LD50ofNaja najavenom was 78.13 µg, standard error (SE) 13.3 µg. The ED50of the Haffkine antivenom againstNaja najavenom was 45.9 mg, SE 7.5 mg. The LD50and ED50ofNaja sumatranavenom were 55.5 µg, SE 12.0 µg; and 73.9 mg, SE 12.0 mg, respectively. The intra-peritoneal ED50against 111 µg intramuscularNaja sumatranavenom was 136.95 mg, SE 36.74 mg.Conclusion. The Haffkine polyvalent antivenom exhibited cross-neutralisation againstNaja sumatranavenom when used at a higher dose.
Minimally Invasive Surgery in Gynecologic Oncology
Authors: Mori Kristina M. , Neubauer Nikki L.
Published: August 2013

Minimally invasive surgery has been utilized in the field of obstetrics and gynecology as far back as the 1940s when culdoscopy was first introduced as a visualization tool. Gynecologists then began to employ minimally invasive surgery for adhesiolysis and obtaining biopsies but then expanded its use to include procedures such as tubal sterilization (Clyman (1963), L. E. Smale and M. L. Smale (1973), Thompson and Wheeless (1971), Peterson and Behrman (1971)). With advances in instrumentation, the first laparoscopic hysterectomy was successfully performed in 1989 by Reich et al. At the same time, minimally invasive surgery in gynecologic oncology was being developed alongside its benign counterpart. In the 1975s, Rosenoff et al. reported using peritoneoscopy for pretreatment evaluation in ovarian cancer, and Spinelli et al. reported on using laparoscopy for the staging of ovarian cancer. In 1993, Nichols used operative laparoscopy to perform pelvic lymphadenectomy in cervical cancer patients. The initial goals of minimally invasive surgery, not dissimilar to those of modern medicine, were to decrease the morbidity and mortality associated with surgery and therefore improve patient outcomes and patient satisfaction. This review will summarize the history and use of minimally invasive surgery in gynecologic oncology and also highlight new minimally invasive surgical approaches currently in development.
Fredholm Weighted Composition Operator on Weighted Hardy Space
Authors: Zhao Liankuo
Published: August 2013

This paper gives a unified characterization of Fredholm weighted composition operator on a class of weighted Hardy spaces.
Spherical Helices for Resonant Wireless Power Transfer
Authors: Škiljo Maja , Blažević Zoran
Published: August 2013

The capabilities of electrically small spherical helical antennas for wireless power transmission at small and moderate distances are analyzed. Influence of design on antenna radiation resistance, efficiency, and mode ratio is examined. These are the factors that, according to the theoretical considerations depicted herein, govern the maximum transfer performances. Various designs and configurations are considered for the purpose, with accent on small-size receivers suitable for implementation in powering common-sized gadgets. It is shown that spherical helix design is easily manipulated to achieve a reduced antenna size. Good radiation characteristics and impedance match are maintained by multiple-arm folded antenna design and by adjusting the separation between the arms.
Pronerve Growth Factor Induces Angiogenesis via Activation of TrkA: Possible Role in Proliferative Diabetic Retinopathy
Authors: Elshaer Sally L. , Abdelsaid Mohammed A. , Al-Azayzih Ahmad , Kumar Parag , Matragoon Suraporn , Nussbaum Julian J. , El-Remessy Azza B.
Published: August 2013

Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF. Increases in proNGF were positively correlated with progression of diabetic retinopathy, having the highest level in ocular fluids from PDR patients compared to nondiabetic patients. Here, we attempted to evaluate the contribution and the possible mechanism of proNGF to PDR. The angiogenic response of aqueous humor samples from PDR patients was examined in human retinal endothelial cells in the presence or absence of anti-proNGF antibody. Additional cultures were treated with mutant-proNGF in the presence of specific pharmacological inhibitors of TrkA andp75NTRreceptors. PDR-aqueous humor samples exerted significant angiogenic response including cell proliferation, migration, and alignment into tube-like structures. These effects were significantly reduced by anti-proNGF antibody but not by IgG. Treatment of retinal endothelial cells with mutant-proNGF activated phosphorylation of TrkA and p38MAPK; however, it did not alterp75NTRexpression. Inhibition of TrkA but notp75NTRsignificantly reduced mutant-proNGF-induced cell proliferation, cell migration, and tube formation. Taken together, these results provide evidence that proNGF can contribute to PDR at least in part via activation of TrkA.
Impulsive Pinning Markovian Switching Stochastic Complex Networks with Time-Varying Delay
Authors: Xu Chen , Wang Jingyi , Feng Jianwen , Zhao Yi
Published: August 2013

The synchronization problem of stochastic complex networks with Markovian switching and time-varying delays is investigated by using impulsive pinning control scheme. The complex network possesses noise perturbations, Markovian switching, and internal and outer time-varying delays. Sufficient conditions for synchronization are obtained by employing the Lyapunov-Krasovskii functional method, Itö's formula, and the linear matrix inequality (LMI). Numerical examples are also given to demonstrate the validity of the theoretical results.
The Frequencies of Gastroesophageal and Extragastroesophageal Symptoms in Patients with Mild Erosive Esophagitis, Severe Erosive Esophagitis, and Barrett’s Esophagus in Taiwan
Authors: Kao Sung-Shuo , Chen Wen-Chih , Hsu Ping-I , Chuah Seng-Kee , Lu Ching-Liang , Lai Kwok-Hung , Tsai Feng-Woei , Chang Chun-Chao , Tai Wei-Chen
Published: August 2013

Background. Gastroesophageal reflux disease (GERD) may present with gastroesophageal and extraesophageal symptoms. Currently, the frequencies of gastroesophageal and extragastroesophageal symptoms in Asian patients with different categories of GERD remain unclear.Aim. To investigate the frequencies of gastroesophageal and extragastroesophageal symptoms in patients with mild erosive esophagitis, severe erosive esophagitis, and Barrett’s esophagus of GERD.Methods. The symptoms of symptomatic subjects with (1) Los Angeles grade A/B erosive esophagitis, (2) Los Angeles grade C/D erosive esophagitis, and (3) Barrett’s esophagus proven by endoscopy were prospectively assessed by a standard questionnaire for gastroesophageal and extragastroesophageal symptoms. The frequencies of the symptoms were compared by Chi-square test.Result. Six hundred and twenty-five patients (LA grade A/B: 534 patients; LA grade C/D: 37 patients; Barrett’s esophagus: 54 patients) were assessed for gastroesophageal and extragastroesophageal symptoms. Patients with Los Angeles grade A/B erosive esophagitis had higher frequencies of symptoms including epigastric pain, epigastric fullness, dysphagia, and throat cleaning than patients with Los Angeles grade C/D erosive esophagitis. Patients with Los Angeles grade A/B erosive esophagitis also had higher frequencies of symptoms including acid regurgitation, epigastric acidity, regurgitation of food, nausea, vomiting, epigastric fullness, dysphagia, foreign body sensation of throat, throat cleaning, and cough than patients with Barrett’s esophagus.Conclusion. The frequencies of some esophageal and extraesophageal symptoms in patients with Los Angeles grade A/B erosive esophagitis were higher than those in patients with Los Angeles grade C/D erosive esophagitis and Barrett’s esophagus. The causes of different symptom profiles in different categories of GERD patients merit further investigations.
Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain
Authors: Ramesh Geeta , MacLean Andrew G. , Philipp Mario T.
Published: August 2013

Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in the central and peripheral nervous systems and in conditions of neuropathic pain. Pathological states within the nervous system can lead to activation of microglia. The latter may mediate neuronal and glial cell injury and death through production of proinflammatory factors such as cytokines and chemokines. These then help to mobilize the adaptive immune response. Although inflammation may induce beneficial effects such as pathogen clearance and phagocytosis of apoptotic cells, uncontrolled inflammation can result in detrimental outcomes via the production of neurotoxic factors that exacerbate neurodegenerative pathology. In states of prolonged inflammation, continual activation and recruitment of effector cells can establish a feedback loop that perpetuates inflammation and ultimately results in neuronal injury. A critical balance between repair and proinflammatory factors determines the outcome of a neurodegenerative process. This review will focus on how cytokines and chemokines affect neuroinflammation and disease pathogenesis in bacterial meningitis and brain abscesses, Lyme neuroborreliosis, human immunodeficiency virus encephalitis, and neuropathic pain.
Effects of Polymeric Additives on the Crystallization and Release Behavior of Amorphous Ibuprofen
Authors: Lee Su Yang , Yu Guiduk , Kim Il Won
Published: August 2013

Some polymeric additives were studied to understand their effects on the amorphous phase of ibuprofen (IBU), used as a poorly water soluble pharmaceutical model compound. The amorphous IBU in bulk, as well as in nanopores (diameter ~24 nm) of anodic aluminum oxide, was examined with the addition of poly(acrylic acid), poly(N‐vinyl pyrrolidone), or poly(4‐vinylphenol). Results of bulk crystallization showed that they were effective in limiting the crystal growth, while the nucleation of the crystalline phase in contact with water was nearly instantaneous in all cases. Poly(N‐vinyl pyrrolidone), the most effective additive, was in specific interaction with IBU, as revealed by IR spectroscopy. The addition of the polymers was combined with the nanoscopic confinement to further stabilize the amorphous phase. Still, the IBU with addition of polymeric additives showed sustained release behavior. The current study suggested that the inhibition of the crystal nucleation was probably the most important factor to stabilize the amorphous phase and fully harness its high solubility.
Fournier's Gangrene as Seen in University of Maiduguri Teaching Hospital
Authors: Aliyu S. , Ibrahim A. G. , Ali N. , Waziri A. M.
Published: August 2013

Background. Fournier’s gangrene is uncommon but increasingly being seen over the last two decades probably due to increasing socioeconomic problems including an upsurge in HIV infection especially in the tropics. Patients and Methods. The study retrospectively reviewed all patients with Fournier’s gangrene managed in UMTH between January 2007 and December 2012. Results. Thirty-eight males aged 2 weeks to 80 years (mean 37.82) were reviewed, with most aged 30–39 years (13 (34.21%)). Clinical features were scrotal pain and swelling, 36 (94.74%), fever, 19 (50.00%), and discharging scrotal wound, 19 (50.00%). The predisposing conditions were UTI secondary to obstructive uropathy in 11 (28.95%), perianal suppuration, and HIV, in 8 (21.05%) patients each. Wound biopsy culture revealed mixed organisms in 27 (71.05%). Twenty-six (68.42%) had blood transfusions. Thirty-seven (97.37%) patients had wound debridement. Twenty (52.63%) had flap rotation for skin cover. There were 6 (15.79%) mortalities, of which 4 (10.53%) were HIV positive, 1 (2.63%) was diabetic, and 1 (2.63%) was both diabetic and HIV positive. Conclusion. Fournier’s gangrene is a fulminant synergistic necrotising fasciitis of the perineum and genitalia with poor prognosis especially when associated with HIV and diabetes, requiringprompt and aggressive management for good outcome.
Fractured Inferior Pubic Ramus with Ipsilateral Total Hip Replacement: A Case Report and Review of the Literature
Authors: Radha Sarkhell , Shenouda Michael , Hazlerigg Alexandra , Konan Sujith , Hulme Alison
Published: August 2013

Pubic rami fractures are common. They are associated with significant morbidity and mortality. These fractures are usually classified as stable injuries and traditionally receive limited orthopaedic input. Management typically involves hospital admission and early input from physiotherapists and occupational therapists. Early mobilisation is advocated as a central part of managing these patients, with emphasis on secondary prevention. We report a case diagnosed as minimally displaced inferior pubic ramus fracture in a patient with an ipsilateral total hip replacement (THR). The patient was mobilised early and despite analgesia continued to complain of groin pain. Repeat radiographs showed a fracture of the acetabulum with displacement of the acetabular component of the hip replacement. We advocate early orthopaedic input for all pubic rami fractures, particularly in patients with hip arthroplasty, and thorough investigation including a CT scan of the pelvis to exclude acetabular extension prior to mobilisation.
Fabrication of Vertically Aligned CNT Composite for Membrane Applications Using Chemical Vapor Deposition through In Situ Polymerization
Authors: Mohammad Munir , Khan Mohammad Bilal , Sherazi Tauqir A. , Anguita Jose , Adikaari Damitha
Published: August 2013

We report the fabrication of vertically aligned carbon nanotubes (CNT) composite using thermal chemical vapor deposition (CVD). A forest of vertically aligned CNTs was grown using catalytic CVD. Fluorocarbon polymer, films were deposited in the spaces between vertically aligned MWCNTs using thermal CVD apparatus developed in‐house. The excessive polymer top layer was etched by exposing the sample to water plasma. Infrared spectroscopy confirmed the attachment of functional groups to CNTs. Alignment of CNTs, deposition of polymer and postetched specimens were analyzed by field emission scanning electron microscope (FE‐SEM). Uniform distribution of monomodel vertically aligned CNTs embedded in the deposited polymer matrix was observed in the micrograph. Observed uniform distribution otherwise is not possible using conventional techniques such as spin coating.
HTCC-Modified Nanoclay for Tissue Engineering Applications: A Synergistic Cell Growth and Antibacterial Efficiency
Authors: Aliabadi Majid , Dastjerdi Roya , Kabiri Kourosh
Published: August 2013

This paper deals with the synthesis of a biocompatible chitosan ammonium salt N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC) and using it in montmorillonite ion-exchange process. HTCC-modified montmorillonite (Mt) with different chemical ratios was successfully synthesized, and their characteristics have been verified by XRD and FTIR analyses. Produced samples have been evaluated in terms of antibacterial efficiency and biocompatibility (cell culture test). Antibacterial efficiency of synthesized HTCC/Mt samples has been confirmed against both gram negative bacteria (Escherichia coli) and gram positive bacteria (Staphylococcus aureus). The results disclosed that the antibacterial efficiency of HTCC-modified montmorillonite was unexpectedly even more than HTCC. This excellent synergistic effect has been referred to entrapping bacteria between the intercalated structures of HTCC-modified montmorillonite. Then HTCC on clay layers can seriously attack and damage the entrapped bacteria. An extraordinary biocompatibility, cell attachment, and cell growth even more than tissue culture polystyrene (TCPS) have been recorded in the case of this novel kind of modified clay. Due to existing concerns about serious and chronic infections after implant placement, this natural-based bioactive and antibacterial modified clay can be used in electrospun nanofibers and other polymeric implants with promising mechanical properties for tissue engineering applications.
Preparation, Characterization, and In Vivo Evaluation of Olanzapine Poly(D,L-lactide-co-glycolide) Microspheres
Authors: D’Souza Susan , Faraj Jabar A. , Giovagnoli Stefano , DeLuca Patrick P.
Published: August 2013

The aim of this study was to prepare injectable depot formulations of Olanzapine using four poly(D,L-lactide-co-glycolide) (PLGA) polymers of varying molecular weight and copolymer composition, and evaluate in vivo performance in rats. In vivo release profiles from the formulations were governed chiefly by polymer molecular weight and to a lesser extent, copolymer composition. Formulations A and B, manufactured using low molecular weight PLGA and administered at 10 mg/kg dose, released drug within 15 days. Formulation C, prepared from intermediate molecular weight PLGA and administered at 20 mg/kg dose, released drug in 30 days, while Formulation D, manufactured using a high molecular weight polymer and administered at 20 mg/kg dose, released drug in 45 days. A simulation of multiple dosing at 7- and 10-day intervals for Formulations A and B revealed that steady state was achieved within 7–21 days and 10–30 days, respectively. Similarly, simulations at 15-day intervals for Formulations C and D indicated that steady state levels were reached during days 15–45. Overall, steady state levels for 7-, 10-, or 15-day dosing ranged between 45 and 65 ng/mL for all the formulations, implying that Olanzapine PLGA microspheres can be tailored to treat patients with varying clinical needs.
Maternal and Perinatal Outcomes of Exercise in Pregnant Women with Chronic Hypertension and/or Previous Preeclampsia: A Randomized Controlled Trial
Authors: Kasawara Karina Tamy , Burgos Camila Schneider Gannuny , do Nascimento Simony Lira , Ferreira Néville Oliveira , Surita Fernanda Garanhani , Pinto e Silva João Luiz
Published: August 2013

Objectives. To evaluate the association between physical exercise supervised in pregnant women with chronic hypertension and/or previous preeclampsia and maternal and neonatal outcomes.Method. Randomized controlled trial, which included 116 pregnant women with chronic hypertension and/or previous preeclampsia, considered risk of preeclampsia development. They were divided into two groups: study group that performed physical exercise with a stationary bicycle once a week, for 30 minutes; the intensity was controlled (heart rate 20% above resting values), under professional supervision and a control group that was not engaged in any physical exercise. The data was retrieved from medical charts. Significance level assumed was 5%.Results. Women from study group performed 9.24 ± 7.03 of physical exercise sessions. There were no differences between groups comparing type of delivery and maternal outcomes, including maternal morbidity and hospitalization in intensive unit care, and neonatal outcomes, including birth weight, adequacy of weight to gestational age, prematurity, Apgar scale at first and fifth minutes, hospitalization in intensive unit care, and neonatal morbidity.Conclusions. Physical exercise using a stationary bicycle in pregnant women with chronic hypertension and/or previous preeclampsia, once a week, under professional supervision, did not interfere in the delivery method and did not produce maternal and neonatal risks of the occurrence of morbidity. This trial is registered with ClinicalTrials.govNCT01395342.
Nutritional Taboos among the Fullas in Upper River Region, The Gambia
Authors: Martínez Pérez Guillermo , Pascual García Anna
Published: August 2013

Malnutrition is one of the leading causes of morbidity and mortality of children in the world. In The Gambia, malnutrition is one of the major public health problems. Among the factors determining its high prevalence, cultural norms play a crucial role. Food taboos influence the amount, frequency, and quality of nutrients that mothers and children consume. In this qualitative study carried out in the Upper River Region, The Gambia, seventeen mothers whose ethnic affiliation is Fulla were interviewed. The objective was to describe their food taboos and how they influence their nutritional health. The findings of this study demonstrate that some of the taboos practiced by the Fulla may be regarded as contributing factors to protein-energy malnutrition in children and pregnant and lactating women. The findings will inform the design of future health education strategies targeting malnutrition in this specific cultural context.
Cadmium and Its Neurotoxic Effects
Authors: Wang Bo , Du Yanli
Published: August 2013

Cadmium (Cd) is a heavy metal that has received considerable concern environmentally and occupationally. Cd has a long biological half-life mainly due to its low rate of excretion from the body. Thus, prolonged exposure to Cd will cause toxic effect due to its accumulation over time in a variety of tissues, including kidneys, liver, central nervous system (CNS), and peripheral neuronal systems. Cd can be uptaken from the nasal mucosa or olfactory pathways into the peripheral and central neurons; for the latter, Cd can increase the blood brain barrier (BBB) permeability. However, mechanisms underlying Cd neurotoxicity remain not completely understood. Effect of Cd neurotransmitter, oxidative damage, interaction with other metals such as cobalt and zinc, estrogen-like, effect and epigenetic modification may all be the underlying mechanisms. Here, we review thein vitroandin vivoevidence of neurotoxic effects of Cd. The available finding indicates the neurotoxic effects of Cd that was associated with both biochemical changes of the cell and functional changes of central nervous system, suggesting that neurotoxic effects may play a role in the systemic toxic effects of the exposure to Cd, particularly the long-term exposure.
Pitfalls in Emergency Department Focused Bedside Sonography of First Trimester Pregnancy
Authors: Layman Kerri , Antonis Michael , Davis Jonathan E.
Published: August 2013

Background. Bedside sonography performed by emergency physicians is frequently utilized for real-time clinical decision-making in the emergency department (ED) setting. This includes the sonographic evaluation of pain or bleeding in the first trimester of pregnancy. The detection of intrauterine pregnancy (IUP) or life-threatening conditions, including ectopic pregnancy, is critical.Objectives. This paper will review several important pearls and avoidable pitfalls of this diagnostic modality by brief presentation of illustrative cases followed by discussion of key principles.Case Reports. Three patients evaluated in the ED for bleeding or pain occurring during the first trimester of pregnancy will be presented.Conclusions. When conducting emergency bedside ultrasound for the evaluation of first trimester pregnancy, it is important to avoid common pitfalls that can place your patient at risk.
MR Image Reconstruction Based on Iterative Split Bregman Algorithm and Nonlocal Total Variation
Authors: Gopi Varun P. , Palanisamy P. , Wahid Khan A. , Babyn Paul
Published: August 2013

This paper introduces an efficient algorithm for magnetic resonance (MR) image reconstruction. The proposed method minimizes a linear combination of nonlocal total variation and least-square data-fitting term to reconstruct the MR images from undersampledk-space data. The nonlocal total variation is taken as theL1-regularization functional and solved using Split Bregman iteration. The proposed algorithm is compared with previous methods in terms of the reconstruction accuracy and computational complexity. The comparison results demonstrate the superiority of the proposed algorithm for compressed MR image reconstruction.
Gene Therapy Approaches to Prevent Corneal Graft Rejection: Where Do We Stand?
Authors: Ritter Thomas , Wilk Mieszko , Nosov Mikhail
Published: August 2013

Cornea transplantation (penetrating keratoplasty) is the most frequently performed transplant procedure in humans. Despite advances in microsurgery and immunosuppressive treatment protocols, a significant number of corneal grafts still undergo immune-mediated allograft rejection. Topical treatment with corticosteroids is currently the gold standard and while this treatment is effective in many corneal transplant patients, it is much less effective in ‘high-risk' patients with previous episodes of neovascularisation or graft rejection. Therefore, alternative approaches such as genetic modification of donor corneas are needed to prevent corneal transplant rejection. Cornea transplantation holds the unique advantage in that gene therapy can be used to modify allografts ex vivo prior to transplantation. Many preclinical studies using local (and systemic) gene transfer have been performed to date and many different gene transfer vehicles (gene therapy vectors) and therapeutic strategies (immunomodulatory or graft-protective) have been investigated to prevent corneal allograft rejection. The most recent gene therapy applications to prevent corneal allograft rejection will be reviewed in this article. Moreover, it will be discussed why the development of clinical trials for the genetic modification of corneal grafts prior to transplantation is lagging behind of those for the treatment of inherited retinal diseases.