bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical Outcomes of Bilateral Inferior Rectus Muscle Recession for Restrictive Strabismus Secondary to Thyroid Eye Disease
Authors: Someda Steffani Krista , Umezawa Naomi , Vaidya Aric , Kakizaki Hirohiko , Takahashi Yasuhiro
Published: October 2023

This retrospective, observational study examined the surgical outcomes of bilateral inferior rectus (IR) recession in thyroid eye disease. Twelve patients who underwent bilateral IR muscle recession were included in the study. Surgical success was defined as patient achievement of the following conditions: (1) a postoperative angle of vertical ocular deviation of ≤3°; (2) a postoperative cyclotropic angle of ≤2°; (3) postoperative binocular single vision, including the primary position; and (4) postoperative enlargement of the field of binocular single vision. Linear regression analyses were performed to analyze the relationship between postoperative changes in the vertical and torsional ocular deviation angles and the amount of IR muscle recession and nasal transposition. Consequently, 9 out of 12 patients were deemed to have had successful surgical outcomes. There was a positive correlation between a change in the vertical deviation angle and a side-related difference in the amount of IR muscle recession in successful cases (crude coefficient, 2.524). A positive correlation was also found between a change in the torsional deviation angle and the amount of IR recession (crude coefficient, 1.059) and nasal transposition (crude coefficient, 5.907). The results will be helpful to more precisely determine the amount of recession and nasal transposition of the IR muscle in patients with thyroid-related bilateral IR myopathy.
Injury of the Vestibulocerebellar Tract and Signs of Ataxia in Patients with Cerebellar Stroke
Authors: Yeo Sang-Seok , Nam Seung-Min , Cho In-Hee
Published: October 2023

Background: The vestibulocerebellar tract (VCT) is responsible for maintaining balance, spatial orientation, and coordination. Damage to the vestibular system is accompanied by symptoms of balance disorder or ataxia. This study aimed to compare cerebellar dysfunction according to VCT damage in patients with cerebellar stroke. Methods: Six patients with cerebellum injury were recruited. This study measured ataxia and hand function related to visuomotor integration and manual dexterity using the Purdue pegboard test. The primary and bilateral secondary VCTs were reconstructed to investigate the integrity of pathways using diffusion tensor imaging (DTI). Results: The ataxia sign was positive in five patients (83%) at onset. In the result of the pegboard test, all patients had hand dysfunction in the dominant hand (100%). Likewise, all patients also had non-dominant hand dysfunction (100%). On the DTI tractography, the left and right primary VCTs of the patients demonstrated a 25% injury rate. Furthermore, the injury rates of ipsilateral and contralateral secondary VCTs were 50% and 58%. Conclusions: Ataxia is related to secondary VCTs, and hand dysfunction is also related to VCTs. Therefore, we believe that the current study will be helpful in evaluating and providing a clinical intervention strategy for patients with ataxia and hand dysfunction following cerebellar injury.
Clinical Outcome of Carbon Fiber Reinforced Polyetheretherketone Plates in Patients with Proximal Humeral Fracture: One-Year Follow-Up
Authors: Ziegler Patrick , Maier Sven , Stuby Fabian , Histing Tina , Ihle Christoph , Stöckle Ulrich , Gühring Markus
Published: October 2023

Background: Proximal humerus fractures are seen frequently, particularly in older patients. The development of new osteosynthesis materials is being driven by the high complication rates following surgical treatment of proximal humerus fractures. Plate osteosyntheses made of steel, titanium and, for several years now, carbon fiber-reinforced polyetheretherketone (CFR-PEEK) are used most frequently. Methods: A prospective, randomized study was conducted in order to evaluate whether there are differences in the functional postoperative outcome when comparing CFR-PEEK and titanium implants for surgical treatment of proximal humerus fractures. The primary outcome of shoulder functionality 1 year after surgery was measured with the DASH score, the Oxford Shoulder Score, and the Simple Shoulder Test. Results: Bony consolidation of the respective fracture was confirmed in all the patients included in the study within the scope of postoperative follow-up care. No significant differences in the DASH score, Oxford Shoulder Score, or Simple Shoulder Test were observed 1 year post-operatively when comparing the implant materials CFR-PEEK and titanium. Conclusions: There are no differences in terms of the functional outcome between CFR-PEEK plates and titanium implants 1 year after surgery. Studies on the long-term outcomes using CFR-PEEK plates in osteoporotic bone should be the subject of further research.
Time to Change Our Viewpoints to Assess Renal Risks in Patients with Solitary Kidneys beyond Traditional Approaches?
Authors: Alp Alper , Saruhan Ercan , Doğan Emrah , Genek Dilek Gibyeli , Huddam Bülent
Published: October 2023

Solitary functioning kidney (SFK) can be defined as the absence or hypofunction of a kidney due to acquired or congenital reasons. A congenital solitary functioning kidney (cSFK) is more common than is an acquired one (aSFK) and is characterized by the anatomical absence (agenesis) or hypofunction (hypoplasia; hypodysplasia) of one kidney from birth. Among the acquired causes, the most important is nephrectomy (Nx) (due to the donor, trauma or mass resection). Patients with SFK are at risk for the development of chronic kidney disease (CKD) in the long term. This risk potential is also significantly affected by hypertension. The relationship between hypertension and subclinical chronic inflammation is a connection that has not yet been fully clarified pathogenetically, but there are many studies highlighting this association. In recent years, studies examining different fibrosis and inflammation biomarkers in terms of the evaluation and prediction of renal risks have become increasingly popular in the literature. Oxidative stress is known to play an important role in homocysteine-induced endothelial dysfunction and has been associated with hypertension. In our study, we aimed to investigate the relationship between ambulatory blood pressure monitoring (ABPM) and urinary/serum fibrosis and inflammatory markers in patients with SFK. We prospectively investigated the relationship between ABPM results and soluble urokinase plasminogen activator receptor (suPAR), procollagen type III N-terminal peptide (PIIINP), homocysteine and other variables in 85 patients with SFK and compared them between cSFK and aSFK groups. In the etiology of SFK, a congenital or acquired origin may differ in terms of the significance of biomarkers. In particular, the serum homocysteine level may be associated with different clinical outcomes in patients with cSFK and aSFK.
Intensive Cardiac Rehabilitation Outcomes in Patients with Heart Failure
Authors: Jafri S. Hammad , Guglin Maya , Rao Roopa , Ilonze Onyedika , Ballut Kareem , Qutrio Baloch Zulfiqar , Qintar Mohammed , Cohn Joel , Wilcox Matthew , Freeman Andrew M. , Kalra Dinesh K. , Wu Wen-Chih
Published: October 2023

Introduction: Cardiac rehabilitation (CR) has proven to be beneficial for patients with heart failure (HF), potentially reducing morbidity and mortality while improving fitness and psychological outcomes. Intensive cardiac rehabilitation (ICR) represents an emerging form of CR that has demonstrated advantages for patients with various cardiovascular diseases. Nevertheless, the specific outcomes of ICR in patients with HF remain unknown. Objectives: The purpose of this study is to assess the effectiveness of ICR in patients with HF. Methods: This retrospective study involved 12,950 patients who participated in ICR at 46 centers from January 2016 to December 2020. Patients were categorized into two groups: the HF group, comprising 1400 patients (11%), and the non-HF group, consisting of 11,550 patients (89%). The primary endpoints included the ICR completion rate, changes in body mass index (BMI), exercise minutes per week (EMW), and depression scores (CESD). A t-test was employed to compare variables between the two groups. Results: The HF group comprises older patients, with 37% being females (compared to 44% in the non-HF group). The ICR completion rate was higher in the non-HF group. After ICR completion, adjusted analyses revealed that patients without HF demonstrated a greater improvement in BMI. There were no differences in fitness, as measured via EMW, or in depression scores, as measured via CESD, between the two groups. Conclusions: Despite the lower baseline functional status and psychosocial scores of HF patients compared to non-HF patients, patients with HF were able to attain similar or even better functional and psychosocial outcomes after ICR.
Anomalous Left Coronary Artery from the Pulmonary Artery: How to Diagnose and Treat
Authors: Blickenstaff Elaina A. , Smith Sean D. , Cetta Frank , Connolly Heidi M. , Majdalany David S.
Published: October 2023

Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare coronary anomaly that can present in childhood or adulthood with a multitude of symptoms depending on the age of presentation. It should be suspected in infants presenting with heart failure in the setting of left ventricular systolic dysfunction and associated mitral regurgitation from papillary muscle ischemia. Adults with ALCAPA may present with cardiac ischemic symptoms. Prompt diagnosis with echocardiography and cross-sectional chest imaging is important to guide surgical intervention and improve the patients’ survival and prognosis. The goal of surgery is to establish a dual-coronary system with mid-term results revealing progressive recovery of left ventricular function and improvement in mitral regurgitation. Patients with ALCAPA should maintain life-long follow-up with a cardiologist with congenital heart disease expertise for surveillance of post-operative complications.
Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride
Authors: Villapalos-García Gonzalo , Zubiaur Pablo , Marián-Revilla Cristina , Soria-Chacartegui Paula , Navares-Gómez Marcos , Mejía-Abril Gina , Rodríguez-Lopez Andrea , González-Iglesias Eva , Martín-Vílchez Samuel , Román Manuel , Ochoa Dolores , Abad-Santos Francisco
Published: October 2023

Tadalafil and finasteride are used in combination for the management of benign prostatic hyperplasia (BPH). Genetic variations in genes involved in the metabolism and transport of tadalafil or finasteride (i.e., pharmacogenes) could affect their pharmacokinetic processes altering their drug exposure, efficacy, and toxicity. The main objective of this study was to investigate the effects of variants in pharmacogenes on the pharmacokinetics of tadalafil and finasteride. An exploratory candidate gene study involving 120 variants in 33 genes was performed with 66 male healthy volunteers from two bioequivalence clinical trials after administration of tadalafil/finasteride 5 mg/5 mg under fed or fasting conditions. Afterwards, a confirmatory study was conducted with 189 male and female volunteers receiving tadalafil 20 mg formulations in seven additional bioequivalence clinical trials. Regarding tadalafil, fed volunteers showed higher area in the time-concentration curve (AUC∞), maximum plasma concentration (Cmax), and time to reach Cmax (tmax) compared to fasting volunteers; male volunteers also showed higher AUC∞ and Cmax compared to female volunteers. Furthermore, fed volunteers presented higher finasteride AUC∞, Cmax and tmax compared to fasting individuals. Variants in ABCC3, CYP1A2, CES1, NUDT15, SLC22A1/A2 and UGT2B10 were nominally associated with pharmacokinetic variation in tadalafil and/or finasteride but did not remain significant after correction for multiple comparisons. Genetic variation did not demonstrate to clinically impact on the pharmacokinetics of finasteride and tadalafil; however, additional studies with larger sample sizes are needed to assess the effect of rare variants, such as CYP3A4*20 or *22, on tadalafil and finasteride pharmacokinetics.
Laser Therapy for Vulvar Lichen Sclerosus, a Systematic Review
Authors: Gil-Villalba Ana , Ayen-Rodriguez Angela , Naranjo-Diaz Maria Jose , Ruiz-Villaverde Ricardo
Published: October 2023

Lichen sclerosus (LS) is a chronic inflammatory disease that mainly affects the anogenital area, with a higher incidence in post-menopausal women. In the long term, it can lead to loss of vulvar architecture or progress to squamous cell carcinoma. The evidence-based treatment involves high-potency topical corticosteroids in long regimens. However, second-line treatments are not well-established, including laser therapy. This current study aims to assess the level of evidence supporting this therapy. We conducted a search for primary-level studies published before April 2023 through MEDLINE/PubMed, Embase, Web of Science, Scopus, and CENTRAL, with no restrictions on the publication language or date. The methodological quality and risk of bias of the included studies were evaluated using the updated Cochrane Collaboration’s tool for assessing risk of bias (RoB-2). Six studies (177 patients) met our eligibility criteria. Laser therapy was compared to topical corticosteroid treatment in five out of six studies. No significant histological differences were found, except for an increase in collagen production in the laser group. A greater reduction in itching, pain, and dyspareunia at 1 and 3 months of treatment in the laser group, as well as in the Skindex-29 at 6 months, was reported. Patient satisfaction was significantly higher among those who received laser therapy. Tolerability was excellent. No significant differences were observed in any of the previous aspects in the study compared to the placebo. In conclusion, there is not enough evidence to recommend laser therapy as a standalone treatment.
Comparison of Rheological Methods to Measure Grease Degradation
Authors: Gurt Alan , Khonsari Michael
Published: October 2023

In a previous paper, methods that have been used to quantify grease mechanical degradation were compared, finding that crossover stress is a practical method for estimating the cone penetration value of a grease using a small sample. This paper covers techniques that have not generally been applied to modeling grease degradation and indicates their usefulness in characterizing the state of a grease. Three methods are examined, each using a different flow profile: rotation, oscillation, and normal force/extension. It is found that crossover stress is likely still the best choice for estimating cone penetration, and a fast, practical method is introduced here. In addition, a procedure for evaluating pull-off force is provided that describes some of the stretching behavior experienced by grease in a rolling contact; this method can also be used as an estimate of cone penetration. Finally, the applications of a “start-up yield” measurement are covered, providing details about the significance of wall slip as well as an independent way of estimating cone penetration.
Microstructure and Bonding Strength of Low-Temperature Sintered Ag/Nano-Ag Films/Ag Joints
Authors: Gao Lihua , Zou Shuangyang , Zheng Changcheng , Mu Dekui
Published: October 2023

Nano-Ag paste is one of the most widely used die-attachment materials in modern electronic devices, which are gaining continuously increasing application in transportation industries. The nano-Ag film in a pre-formed dimension and free from the use of chemical dispersing agents has been proposed to be a promising alternative to nano-Ag paste for the die-attachment application. Although the bonding mechanisms of Nano-Ag paste have been extensively studied, little is known about the relationship between the microstructure and mechanical properties of low-temperature-sintered Ag/nano-Ag film/Ag joints. In this work, the influences of temperature, pressure, and dwell time at peak temperature on the microstructure and the shear strength of low-temperature-sintered Ag/nano-Ag film/Ag joints were systematically investigated. Mechanical properties tests indicate that both temperature and pressure have pronounced effects on the bonding strength of sintered Ag/nano-Ag film/Ag joints. TEM and hot nanoindentation characterizations further reveal that the sintering temperature plays the most determinant role in the coarsening of nano-Ag film and, hence, the bonding and fracture behaviors of Ag/nano-Ag film/Ag joints sintered at 210–290 °C. The diffusion-induced coarsening of nano-Ag particles can be activated, but remains sluggish at 250 °C, and the mechanical integrity of sintered joints is circumscribed by the interfacial bonding between nano-Ag film and Ag substrate after sintering at 290 °C.
Exploring the Variability in Antibacterial Testing of Resin Dental Composites among Investigators: A Narrative Review
Authors: Pal Ashlesha , Altaf Noorulain , Mahmood Anum , Akbar Shazia , Maher Nazrah , Kumar Naresh , Zafar Muhammad Sohail , Murcia Laura , Oñate-Sánchez Ricardo E.
Published: October 2023

Caries is a common dental problem brought on by factors like excessive sugar consumption, poor oral hygiene, and the presence of microorganisms in the mouth. This dental pathology is treated with a variety of filling materials, including tooth-colored direct resin dental composite (RDC), glass ionomer cement (GIC), and dental amalgam (also known as silver filling). RDC is the most preferred filling material in dental clinics due to its excellent esthetics and minimal tooth preparation, making it the need of the modern era. However, antimicrobial agents were added to this material in order to enhance its ability to prevent secondary caries. The antibacterial activity of RDC has been tested using a variety of methods, but testing protocols have been found to vary. Thusly, the point of this article is to examine the disparity in the strategy involved by specialists for testing the antibacterial properties of RDCs.
The Role of Mg Doping in Manipulating the Adsorption Mechanisms of CaAl-Layered Double Hydroxide: Investigating the Effects of Calcination Temperature and Borate Concentration Changes
Authors: Xu Shuang , Guo Binling , Sasaki Keiko , Qiu Xinhong
Published: October 2023

CaAl-layered double hydroxides (LDHs) exhibit different mechanisms of borate removal at varying calcination temperatures. The addition of Mg alters the structure and composition of the calcined products, ultimately impacting their adsorption process. To investigate this, CaAl-LDH and Mg-doped CaAl-LDH with and without different calcination temperatures (500 °C and 900 °C) were prepared to immobilize a wide concentration range of borate. XRD, SEM, FTIR, and EXAFS techniques were employed to study the influence of Mg doping. The results indicate that the doping of Mg increases the BET surface area and enhances the adsorption capacity of uncalcined LDHs, with the enhancement being more pronounced at high borate concentrations. For LDHs calcined at 500 °C, Mg-doped LDHs exhibited slightly better adsorption at any borate concentration due to its more favorable ettringite formation. However, for LDHs calcined at 900 °C, Mg-doped LDHs (LDO) had a slightly better adsorption effect at low borate concentrations. At high concentrations, the crystallinity and morphology of the regenerated CaMgAl-LDH deteriorated, resulting in poor adsorption effects. These findings provide valuable theoretical support for understanding the mechanisms of removing pollutants with different concentrations by different LDHs.
Correction: Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256
Authors: Bischoff Nicolaj , Proquin Héloïse , Jetten Marlon , Schrooders Yannick , Jonkhout Marloes , Briedé Jacco , van Breda Simone , Jennen Danyel , Medina-Reyes Estefany , Delgado-Buenrostro Norma , Chirino Yolanda , van Loveren Henk , de Kok Theo
Published: October 2023

In the published publication [...]
Selected I-III-VI2 Semiconductors: Synthesis, Properties and Applications in Photovoltaic Cells
Authors: Shishodia Shubham , Chouchene Bilel , Gries Thomas , Schneider Raphaël
Published: October 2023

I–III–VI2 group quantum dots (QDs) have attracted high attention in photoelectronic conversion applications, especially for QD-sensitized solar cells (QDSSCs). This group of QDs has become the mainstream light-harvesting material in QDSSCs due to the ability to tune their electronic properties through size, shape, and composition and the ability to assemble the nanocrystals on the surface of TiO2. Moreover, these nanocrystals can be produced relatively easily via cost-effective solution-based synthetic methods and are composed of low-toxicity elements, which favors their integration into the market. This review describes the methods developed to prepare I-III-VI2 QDs (AgInS2 and CuInS2 were excluded) and control their optoelectronic properties to favor their integration into QDSSCs. Strategies developed to broaden the optoelectronic response and decrease the surface-defect states of QDs in order to promote the fast electron injection from QDs into TiO2 and achieve highly efficient QDSSCs will be described. Results show that heterostructures obtained after the sensitization of TiO2 with I-III-VI2 QDs could outperform those of other QDSSCs. The highest power-conversion efficiency (15.2%) was obtained for quinary Cu-In-Zn-Se-S QDs, along with a short-circuit density (JSC) of 26.30 mA·cm−2, an open-circuit voltage (VOC) of 802 mV and a fill factor (FF) of 71%.
Prevalence and Molecular Characterization of Shiga Toxin-Producing Escherichia coli from Food and Clinical Samples
Authors: Alotaibi Khulud , Khan Ashraf A.
Published: October 2023

Shiga toxin-producing Escherichia coli (STEC) is one of the most prominent food-borne pathogens in humans. The current study aims to detect and to analyze the virulence factors, antibiotic resistance, and plasmid profiles for forty-six STEC strains, isolated from clinical and food strains. Pulsed-field gel electrophoresis (PFGE) was used to determine the genetic relatedness between different serotypes and sources of samples. The clinical samples were found to be resistant to Nb (100%), Tet (100%), Amp (20%), SXT (15%), and Kan (15%) antibiotics. In contrast, the food strains were found to be resistant to Nb (100%), Tet (33%), Amp (16.6%), and SXT (16.6%) antibiotics. The PFGE typing of the forty-six isolates was grouped into more than ten clusters, each with a similarity between 30% and 70%. Most of the isolates were found positive for more than five virulence genes (eae, hlyA, stx1, stx2, stx2f, stx2c, stx2e, stx2, nelB, pagC, sen, toxB, irp, efa, and efa1). All the isolates carried different sizes of the plasmids. The isolates were analyzed for plasmid replicon type by PCR, and 72.5% of the clinical isolates were found to contain X replicon-type plasmid, 50% of the clinical isolates contained FIB replicon-type plasmid, and 17.5% of the clinical isolates contained Y replicon-type plasmid. Three clinical isolates contained both I1 and Hi1 replicon-type plasmid. Only two food isolates contained B/O and W replicon-type plasmid. These results indicate that STEC strains have diverse clonal populations among food and clinical strains that are resistant to several antimicrobials. In conclusion, our findings indicate that food isolates of STEC strains harbor virulence, antimicrobial resistance, plasmid replicon typing determinants like those of other STEC strains from clinical strains. These results suggest that these strains are unique and may contribute to the virulence of the isolates. Therefore, surveillance and characterization of STEC strains can provide useful information about the prevalence of STEC in food and clinical sources. Furthermore, it will help to identify STEC serotypes that are highly pathogenic to humans and may emerge as a threat to public health.
Unveiling Apple Diversity: The Quality of Juice Produced from Old vs. Commercial Apple Cultivars
Authors: Lončarić Ante , Flanjak Ivana , Kovač Tihomir , Tomac Ivana , Skoko Ana-Marija Gotal , Babojelić Martina Skendrović , Fruk Goran , Zrinušić Sanja Zec , Čiček Danijel , Babić Jurislav , Jozinović Antun
Published: October 2023

This research is focused on comparing the compositions of juice produced from old and commercially grown apple cultivars. We examined factors such as pH, total acids, soluble dry matter, polyphenol profile, and antioxidant activity, which impact the attributes, safety, shelf life, and nutritional value of the juice. Our analysis revealed differences between these two groups of cultivars. For instance, pH values ranged from 3.04 (in ‘Bobovec’) to 3.69 (in ‘Fuji’). The proportions of acids varied from 0.07 g/100 mL (in ‘Fuji’) to 0.19 g/100 mL (in ‘Wagener’). Soluble dry matter content ranged from 14.10% (in ‘Fuji’) to 18.50% (in ‘Kraljevčica’). We also observed variations in sugar content and composition among cultivars; for example, sucrose levels varied from 16.11 g/L (‘Fuji’) to 39.36 g/L (‘Golden Delicious). Glucose levels ranged from 4.95 g/L (‘Jonagold’) to 19.18 g/L (‘Fuji’), while fructose levels spanned from 50.78 g/L (‘Austrougarka’) to 427.97 g/L (‘Ilzer Rosenapfel’). Furthermore, old apple cultivars exhibited higher concentrations of phenols and flavonoids compared to commercial ones; we also noted significant variations in flavonol levels among different cultivars. The ‘Wagener’ and ‘Božićnica’ apple varieties had levels of myricetin measuring 0.53 and 0.52 µg/mL, respectively. On the other hand, ‘Bobovec’ stood out for its content of procyanidin B2 with a concentration of 422.61 µg/mL. When examining non-flavonoid compounds, it was found that old apple cultivars had higher concentrations of gallic acid, trans-ferulic acid, and chlorogenic acid. However, commercial cultivars showed dominance in caffeic and p-coumaric. Comparisons of antioxidant capacity using DPPH and ABTS assays clearly demonstrated the superiority of old apple cultivars. Overall, this study highlights the importance of utilizing apple cultivars for juice production. Their distinct compositions and higher antioxidant capacities contribute to potential health benefits. Preserving these cultivars for enhanced juice quality and nutritional value is encouraged. Further research could explore cultivation practices’ impact on composition and health benefits.
QTL Verification and Candidate Gene Screening of Fiber Quality and Lint Percentage in the Secondary Segregating Population of Gossypium hirsutum
Authors: Liu Ruixian , Zhu Minghui , Shi Yongqiang , Li Junwen , Gong Juwu , Xiao Xianghui , Chen Quanjia , Yuan Youlu , Gong Wankui
Published: October 2023

Fiber quality traits, especially fiber strength, length, and micronaire (FS, FL, and FM), have been recognized as critical fiber attributes in the textile industry, while the lint percentage (LP) was an important indicator to evaluate the cotton lint yield. So far, the genetic mechanism behind the formation of these traits is still unclear. Quantitative trait loci (QTL) identification and candidate gene validation provide an effective methodology to uncover the genetic and molecular basis of FL, FS, FM, and LP. A previous study identified three important QTL/QTL cluster loci, harboring at least one of the above traits on chromosomes A01, A07, and D12 via a recombinant inbred line (RIL) population derived from a cross of Lumianyan28 (L28) × Xinluzao24 (X24). A secondary segregating population (F2) was developed from a cross between L28 and an RIL, RIL40 (L28 × RIL40). Based on the population, genetic linkage maps of the previous QTL cluster intervals on A01 (6.70–10.15 Mb), A07 (85.48–93.43 Mb), and D12 (0.40–1.43 Mb) were constructed, which span 12.25, 15.90, and 5.56 cM, with 2, 14, and 4 simple sequence repeat (SSR) and insertion/deletion (Indel) markers, respectively. QTLs of FL, FS, FM, and LP on these three intervals were verified by composite interval mapping (CIM) using WinQTL Cartographer 2.5 software via phenotyping of F2 and its derived F2:3 populations. The results validated the previous primary QTL identification of FL, FS, FM, and LP. Analysis of the RNA-seq data of the developing fibers of L28 and RIL40 at 10, 20, and 30 days post anthesis (DPA) identified seven differentially expressed genes (DEGs) as potential candidate genes. qRT-PCR verified that five of them were consistent with the RNA-seq result. These genes may be involved in regulating fiber development, leading to the formation of FL, FS, FM, and LP. This study provides an experimental foundation for further exploration of these functional genes to dissect the genetic mechanism of cotton fiber development.
Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging
Authors: Alves-Silva Jorge M. , Moreira Patrícia , Cavaleiro Carlos , Pereira Cláudia , Cruz Maria Teresa , Salgueiro Lígia
Published: October 2023

With the increase in global life expectancy, maintaining health into old age becomes a challenge, and research has thus concentrated on various strategies which aimed to mitigate the effects of skin aging. Aromatic plants stand out as promising sources of anti-aging compounds due to their secondary metabolites, particularly essential oils (EOs). The aim of this study was to ascribe to Ferulago lutea EO several biological activities that could be useful in the context of skin aging. The EO was obtained using hydrodistillation and characterized by gas chromatography–mass spectrometry (GC/MS). The anti-inflammatory potential was assessed using lipopolysaccharide (LPS)-stimulated macrophages. The effect on cell migration was disclosed using scratch wound assay. Lipogenesis was induced using T0901317, hyperpigmentation with 3-isobutyl-1-methylxantine (IBMX) and senescence with etoposide. Our results show that the EO was characterized mainly by α-pinene and limonene. The EO was able to decrease nitric oxide (NO) release as well as iNOS and pro-IL-1β protein levels. The EO promoted wound healing while decreasing lipogenesis and having depigmenting effects. The EO also reduced senescence-associated β-galactosidase, p21/p53 protein levels and the nuclear accumulation of γH2AX. Overall, our study highlights the properties of F. lutea EO that make it a compelling candidate for dermocosmetics applications.
Critical Thinking and Student Well-Being: An Approach in University Students
Authors: Vázquez-Parra José Carlos , Suárez-Brito Paloma , Alonso-Galicia Patricia Esther , Echaniz-Barrondo Arantza
Published: October 2023

Human well-being is a dynamic and changing concept as it depends on personal, social, cultural, and political factors and varies over time according to individual circumstances. Therefore, it is essential to address this issue from a comprehensive and multidisciplinary approach, seeking that individuals, from an early age, manage to develop skills and attitudes that allow them to achieve a balance in their lives. This article presents the results of the measurement of students’ perceived achievement of the competence of complex thinking in a subject focused on human development. Specifically, the research sought to identify whether there is a relationship between the level of critical thinking and the acquisition of skills associated with human well-being. The selection of critical thinking is based on the fact that this cognitive ability is one of the subcompetencies included in complex thinking. The sample was a group of university students from different disciplines and educational levels. Methodologically, descriptive analyses were made on the means of students’ responses to a validated instrument measuring the perceived achievement of complex thinking competency and its subcompetencies and the final evaluations of the students’ course. In conclusion, an improvement in the perception of achievement of complex thinking competency and its subcompetencies is demonstrated in the students, with critical thinking that achieved the best means, its increase being significant for the whole group and for women but not for men. In this sense, although it was not possible to demonstrate a statistically significant relationship between the development of this subcompetency and the acquisition of tools associated with well-being, data showing a possible association between these elements were obtained.
PENGARUH PENYULUHAN KESEHATAN TERHADAP PENGETAHUAN DAN SIKAP REMAJA TENTANG KESEHATAN REPRODUKSI DI SMA NEGERI 1 CISARUA TAHUN 2017
Authors: Agustin Marini , Ningtyas Inggar Tresna
Published: October 2023

Remaja adalah masa dimana mereka tidak bias disebut sebagai anak-anak lagi danbelum bisa pula disebut sebagai dewasa, yang mengalami perubahan secara fisik, fisiologis, psikis,emosi dan terjadinya perubahan social dan moralnya. Remaja memerlukan informasi yang benar,jelas,dan bertanggung jawab mengenai kesehatan reproduksi. Informasi tersebut dapat diperoleh dariorang tua, sekolah, lembaga kesehatan, dan pihak-pihak yang dipandang lebih mengerti dan memilikitanggung jawab atas permasalahan tersebut. Pengetahuan dan sikap tentang kesehatan reproduksi harusdikuasai dan dipahami oleh remaja sebagai bekal mempersiapkan kehidupan berkeluarga. TujuanUntuk mengetahui pengaruh penyuluhan kesehatan terhadap pengetahuan dan sikap remaja tentangkesehatan reproduksi di SMA Negeri 1 Cisarua. Metode penelitian ini menggunakan metodeekperimen dengan desain pretest dan posttest one group. Populasi dalam penelitian ini berjumlah 287orang siswa dan jumlah sampel yang diperoleh sebanyak 74 responden. Hasil penelitian berdasarkanuji t paired sample test dengan derajat kemaknaan 10% pada variable pengetahuan pre-test dan posttest diperoleh nilap p = 0,000 (P<0,1) dan variable sikap pre-test dan post-test diperoleh nilap p = 0,000(P<0,1). Kesimpulan : Penyuluhan mempunyai pengaruh signifikan terhadap pengetahuan dan sikapremaja tentang kesehatan reproduksi. Saran diharapkan agar lebih meningkatkan program promosikesehatan khususnya mengenai remaja dan segala permasalahannya.
MARKETING STRATEGY FOR ECOTOURISM PRODUCTS IN LABUAN BAJO, EAST NUSA TENGGARA
Authors: Adi Husnaini
Published: October 2023

Ecotourism is part of sustainable tourism, where special attention is needed regarding environmental, economic, and social sustainability. Sustainable tourism is very much needed in the current era in order to preserve the nature and culture of an area. Sustainable tourism also involves the community fully, so that the impacts can be felt fully by the community directly. The purpose of this paper is to determine the internal and external factors needed to build a marketing strategy at the two research locations as well as to formulate a strategy based on SWOT analysis. The method used is descriptive-qualitative, using interviews, observation, and literature study, using the SWOT analysis technique. The results of this study show that there are several marketing programs that can be implemented in research locations, starting with product packaging, promotion, repositioning, and improving tourism services. Ecotourism destinations, learning from the benchmarking choices of researchers, and targeted marketing are aimed at special interest tourists. A visitor limit is being implemented with the goal of adjusting to the capacity of the conservation environment. so that the marketing strategy that is carried out should not invite mass tourism. However, collaboration and participation from other tourism actors are also needed in the promotion and management of destinations.

Keywords:  Environmental analysis, resources, ecotourism
Peran Solo International Performing Art (SIPA) Sebagai Penguatan Branding Solo The Spirit Of Java
Authors: Dewati Nur , Dr. Meitolo Hulu, S.ST., M.M.
Published: October 2023

Solo International Performing Art (SIPA) is a tourism event held in Solo, Central Java. SIPA is one of the pioneers and a legendary event and continue for 15 years. SIPA is a leading event, involving international delegations and becoming the icon of the Solo City cultural festival. The Solo Government has the brand “Solo The Spirit Of Java” which has been used for 17 years and is still considered very relevant. This research wants to see how SIPA as a leading event contributes to strengthening the branding "Solo The Spirit Of Java". This study uses a qualitative descriptive approach, data obtained by in-depth interviews with purposive sampling of key informants, SIPA CEO, SIPA Manager, Tourism Office and Festival Activists. The results showed that SIPA strengthened Solo city branding through various things, namely Javanese cultural content at the SIPA event, event themes, event locations, promotional materials and event publications which were carried out massively and highlighted Solo as a Javanese cultural city. The use of the ornament branding "Solo The Spirit Of Java" in the design and implementation of the event becomes an inseparable identity. SIPA strengthens Solo's branding as a leading event that is promoted internationally throughout the year by collaborating across stakeholders and involving volunteers (SIPA community), media and community partners. SIPA has succeeded in encouraging tourist visits to Solo through holding events for both domestic and foreign tourists. Expert opinion says that SIPA strengthens solo branding through display and content.
Pengaruh Entertainment dan Informativeness terhadap Keputusan Berpartisipasi dalam Mengikuti Event Talks
Authors: Audita Vanda Nirma , Suryadana Moch Liga , Sukmadi
Published: October 2023

Indonesia Event Industry Council (IVENDO) in 2020 showed that 43% of events were canceled and 48% were postponed during the pandemic. One of the innovations that are considered to be able to provide solutions for the current event industry is virtual events. One that adapts the implementation of virtual events is the convention and event management study program from the Bandung NHI Tourism Polytechnic which applies practical activities by implementing virtual events. The event held is a webinar series with the name event talks. This study aims to examine the effect of the entertainment variable and informativeness variable on the decision to participate in event talks. This research was conducted with a quantitative approach by distributing questionnaires to 165 respondents from year 2022 who had participated in event talks using a purposive sampling technique. The theory used is the entertainment theory of Horner (2005), the theory of informativeness from Suyanto (2000), and the theory of participating decisions from Allen (2011). The results of the study explain that entertainment and informatics significantly influence the decision to participate in event talks by 37.6% while the remaining 62.4% is influenced by other variables not examined in this study. Thus, in the future, the organizers can pay attention to aspects of other variables that can be an attraction for potential participants.
Effects of Using Arabic Web Pages in Building Rank Estimation Algorithm for Google Search Engine Results Page
Authors: Almadhoun Mohamed , Malim Nurul
Published: October 2023

Search Engine Optimization (SEO) aims to improve a website's reputation and user experience. Without effective SEO strategies, it requires significant investment in paid advertisements. Search Engines (SEs) use algorithms to rank results, assessing on-page and off-page factors for relevance. Machine learning techniques have been used to build classifiers for estimating page rank. However, no research has compared rank estimation with other languages or analyzed the effects of different languages on performance or differences between SEO factors. The study aims to improve rank estimation algorithms for Arabic web pages on desktop devices using a new multi-category dataset from Google Search Engine Results Page (SERP). The experimental findings suggest that Arabic web pages are more suitable than English ones for training a model to estimate the ranking of Arabic web pages. Machine learning models were applied to two datasets. SE scraping was used to collect URLs, descriptions, and other data from the Google SE. Data preprocessing steps were taken before using the datasets for rank estimation algorithms. Experiments were conducted to assess the implications of using Arabic and English web page datasets
Zwischen Avignon, München und Tortosa. Die Defensor pacis-Handschrift des Marsilius von Padua in der Bibliothek Benedikts XIII
Authors: Fidora Alexander , Tischler Matthias M.
Published: October 2023

While Marsilius of Padua’s Defensor pacis is considered as one of the most important medieval tracts of political theory, the history of the text has not been adequately reconstructed so far. This paper examines the manuscript Tortosa, Arxiu Capitular de la Catedral, Ms. 141, which provides in all probability a revision of the Defensor pacis by the author himself, as is shown by means of a paleographical analysis as well as through textual comparison with Marsilius’ Defensor minor. In addition, it proves that the manuscript was present in Avignon at the latest at the time of Benedict XIII, thus confirming its central place in the controversy between Marsilius of Padua and the papal curia in Avignon.
Генерація та використання змагальної вибірки для протидії ухиленню ботнетів від виявлення нейронними мережами (до 100-річчя з дня народження академіка В.М. Глушкова)
Authors: Панчук Богдан Олександрович
Published: October 2023

Описано спосіб проведення оцінки надійності систем виявлення ботнетів на основі нейронних мереж, з точки зору їх вразливості до змагальних атак, і підвищення стійкості таких систем через розширення навчального набору штучними даними. Під «змагальною атакою» мається на увазі цілеспрямована спроба зловмисника штучно модифікувати дані (у даному разі — потоки мережевих пакетів) для спроби ухилення від виявлення класифікатором. Запропонований та реалізований метод генерації змагальних прикладів для системи класифікації трафіку на основі нейронної мережі шляхом адаптації «методу швидкого знаку градієнта», відомого з області обробки зображень, для роботи з мережевими даними, представленими у формі мережевих потоків. Характерними рисами описаного підходу є обчислювальна простота, а також правдоподібність отриманих прикладів трафіку. Правдоподібність штучно створених екземплярів потоків забезпечувалась накладанням глобальних споріднених груп ознак, над якими проводились модифікації. Окрім застосування описаного підходу, для оцінки вразливості моделей класифікації також показана можливість його застосування для доповнення початкової навчальної вибірки штучними даними. Спершу базова модель класифікації була навчена на відкритому наборі даних трафіку ботнетів. Далі початковий набір був розширений змагальними прикладами, згенерованими описаним методом, після цього було експериментально показано, що модель, навчена на розширених даних, більш стійка до змагальних атак порівняно з базовою. При цьому метод не є специфічним лише для області виявлення ботнетів, а може застосовуватися для мережевих атак іншого роду за умови наявності відповідного навчального набору. Запропоновано напрямки для подальшого розвитку цього підходу.
Decision Support System for Loan Eligibility using the Simple Additive Weighting (SAW) Method
Authors: Kurnia M Reza Tri , Mandala Eka Praja Wiyata , Prawiro Radius
Published: October 2023

The Solok City Bakti Husada Employees Cooperative is a non-bank financial institution in the form of a cooperative that serves the needs of its members in lending services with collateral in the form of member savings. The aim of this research is to make it easier for the Bakti Husada Cooperative to determine the suitability of loans to borrowers and to create a Decision Making System using the Simple Additive Weighting (SAW) method which is able to assist the Bakti Husada Cooperative in determining the suitability of loans to borrowers. The data collection method was carried out by direct observation and interviews with employees from the Bakti Husada Cooperative, Solok City. The results obtained are effective in making decisions about loan eligibility at the Bakti Husada Cooperative in Solok City in accordance with the criteria that have been determined in the selection. This result is proven. By using this system, members who apply for a loan get a score that is in accordance with the criteria and weights that have been set and from there it can be seen if there are criteria that are not in accordance with the standard requirements of the member's application for a loan so that members can improve the loan requirements so that Loan applications are accepted by the cooperative. Gusnelawati obtained the calculation results using the SAW method to determine the feasibility of providing loans to cooperatives with a value of 0.9625 and was the 1st Best in making this decision.
Pengaruh Book Tax Differences, Volatilitas Arus Kas, dan Besaran Akrual Terhadap Persistensi Laba
Authors: Kholilah Yesi Intan , Wulandari Rosita
Published: October 2023

Penelitian ini bertujuan untuk menganalisis dan memberikan bukti secara empiris mengenai pengaruh book tax differences, volatilitas arus kas, dan besaran akrual terhadap persistensi laba pada perusahaan manufaktur sektor basic materials yang terdaftar di Bursa Efek Indonesia periode 2016-2021. Penelitian ini menggunakan jenis penelitian kuantitatif dan menggunakan data sekunder yaitu berupa laporan keuangan tahunan. Teknik pengambilan sampel menggunakan metode purposive sampling dan memperoleh sebanyak 20 perusahaan selama 6 tahun. Teknik analisis data menggunakan metode analisis regresi data panel dan program software Eviews versi 9. Berdasarkan hasil penelitian menunjukkan bahwa secara parsial variabel book tax differences perbedaan permanen tidak berpengaruh signifikan terhadap persistensi laba, sedangkan variabel book tax differences perbedaan temporer, volatilitas arus kas, dan besaran akrual serta tingkat utang berpengaruh signifikan terhadap persistensi laba. Sementara, secara simultan book tax differences, volatilitas arus kas, dan besaran akrual serta tingkat utang berpengaruh signifikan terhadap persistensi laba.
Penerapan Metode One Day One Ayat dalam Meningkatkan Motivasi Menghafal Al-Qur’an Surat An-Naba’ dan An-Nazi’at pada Santri Kelas 4 di Rumah Tahfidz Daarul Hijrah
Authors: Safitri Laila Nur , Akil Akil , Nurlaeli Acep
Published: October 2023

Penelitian ini dilatarbelakangi karena adanya ketidaksesuaian guru pembimbing tahfidz dalam menggunakan metode atau cara mengajar dengan cara sistem setoran, yang dimana santri sudah melanjutkan ke ayat berikutnya padahal mereka belum terlalu hafal ayat sebelumnya, sehingga menyebabkan adanya santri yang masih tersendat-sendat dalam setoran hafalan, terlewat bacaan ayatnya ketika setoran dan masih tidak sesuai menggunakan tajwid maupun makharijul hurufnya dalam setoran hafalan. Penelitian ini bertujuan untuk mengetahui 1. Penerapan Metode One Day One Ayat dalam meningkatkan motivasi menghafal Al-Quran Surah An-Naba dan An-Nazi’at, 2. Meningkatnya motivasi menghafal Al-Qur’an surat An-Naba’ dan An-Nazi’at, dan 3. Bagaimanakah faktor pendukung dan penghambat pada penerapan metode one day one ayat dalam meningkatkan motivasi menghafal surat An-Naba’ dan surat An-Nazi’at. Jenis penelitian dalam penelitian ini adalah penelitian lapangan, dengan pendekatan kualitatif. Adapun subyek penelitiannya yaitu guru pembimbing tahfidz, guru pengurus, santri dan wali santri. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu observasi, wawancara dan dokumentasi. Dalam menganalisis data, tahap-tahap yang digunakan yaitu dengan reduksi data, penyajian data dan penarikan kesimpulan. Dari hasil penelitian dan pembahasan menunjukan bahwa penerapan metode ODOA diterapkan bagi santri yang sudah lancar hafalannya, jika sudah lancar maka guru pembimbing akan menargetkan hafalan baru satu ayat dengan mendikte per penggalan ayat selanjutnya untuk dihafal. Kemudian, guru pembimbing menggunakan kata kunci di setiap ayatnya dan ketukan pada tajwid yang digunakan untuk mengantisipasi dari lupa hafalan serta ketidaktepatan dalam menggunakan tajwid pada setiap ayat.