bluuebunny/crossref_metadata_2025 huggingface dataset:
Imaging of cervical cancer. Consensus of experts
Authors: Rubtsova N. A. , Berezovskaia T. P. , Bychenko V. G. , Pavlovskaya E. A. , Solopova A. E. , Agababyan T. A. , Khodzhibekova M. M. , Ryzhkova D. V. , Chekalova M. A. , Meshkova I. E. , Gazhonova V. E. , Gus A. I. , Bagnenko S. S. , Medvedeva B. M. , Ashrafyan L. A. , Novikova E. G. , Berlev I. V. , Demidova L. V. , Krikunova L. I. , Kolomiets L. A.
Published: December 2023

The article offers the latest view on possibilities of diagnostic algorithm to identify cervical cancer (CC), one of the most incidental tumor of the woman’s reproductive system. The algorithm is described as a consensus of leading expert in imaging diagnostics, as well as oncogynecologysts, investigating diagnostic challenges and cervical cancer therapies. The article sets forth the principal trends in using imaging methods, their role and possibilities for staging CC, planning and assessing the efficacy of applied therapy, on-going surveillance over patients, who have undergone specialized anti-cancer treatment.
Role of echocardiography in heart failure with preserved ejection fraction
Authors: Soldatova A. M. , Shirokov N. Е. , Yaroslavskay E. I.
Published: December 2023

This study aimed to investigate and analyze data regarding the role of echocardiographic examination in assessing the diastolic function of the left ventricle and diagnosing heart failure with preserved ejection fraction (HFpEF).

Materials and methods. A search of scientific publications and clinical recommendations was conducted in the PubMed and Google Scholar information-analytical systems for the years 2016–2022, using keywords such as diastolic dysfunction, diastolic stress test, heart failure with preserved ejection fraction, and echocardiography. Additionally, literature lists were analyzed to identify articles meeting the search criteria.

Results. A total of 140 articles were analyzed, with 27 of them utilized in composing the review. Eleven additional articles from 2003–2015 were included from literature lists. The search results were organized into article blocks, within which articles were analyzed to study the role of echocardiographic examination in assessing the diastolic function of the left ventricle and diagnosing HFpEF.

Conclusion: Echocardiographic examination provides crucial information about the structure and function of the heart and is recommended for all patients with suspected HFpEF. Based on routine assessment of tissue Doppler imaging parameters, ultrasound diagnostic physicians can decide on the need to initiate the diagnostic algorithm for HFpEF using the diastolic stress test method. Results of the diastolic stress test, considering its limitations, should be interpreted in accordance with the clinical scenario or the probability of the presence of HFpEF. A reduction in diastolic reserve (E/e > 15) is a cornerstone for confirming HFpEF. The key task of upcoming clinical trials is to better differentiate various clinical phenotypes of HFpEF, thereby improving the treatment of each specific patient with HFpEF.
Clinical application of new classification of the calyx-pelvic system dilation UTD in children in a perinatal center
Authors: Sugak A. B. , Babatova S. I. , Filippova E. A. , Batdalova Z. N. , Podurovskaya Yu. L. , Pavlova V. S. , Pekareva N. A. , Pykov M. I. , Zubkov V. V.
Published: December 2023

The aim of the study was to evaluate the clinical significance of the new urinary tract dilation classification (UTD-2014) in predicting outcomes of the calyx-pelvic system dilation detected by ultrasound (US) in children in the perinatal center.

Materials and methods. A retrospective analysis of the urinary system ultrasound protocols and the outcomes of 152 children with dilated calyx-pelvic system due to various causes examined at the National Medical Research Center for Obstetrics, Gynecology and Perinatology for the period from 2017 to 2022 was carried out.

Results. The median age of patients at the time of the first ultrasound was 2 days, the median duration of follow -up was 10 months. The decrease in the UTD category during the observation period occurred in –/35/29/10% of patients in groups with the primary established UTD category 0/I/II/III, respectively. The UTD category remained the same in 42%, an increase in the category occurred in 32/26/4/-% of patients with UTD 0/I/II/III, respectively. The age at the time of the first ultrasound of patients who had an increase in the UTD category (median – 2 (1; 3.5) days) was significantly less than in other children (with the exception of operated patients). Surgical intervention was performed by 0/2/31/60% of patients with UTD category 0/I/II/III (only 18%), respectively.

Conclusions. UTD classification correlates well with outcomes of the calyx-pelvic system dilation due to various causes in children – the larger the category according to primary ultrasound, the less often its decrease or lack of dynamics is noted during follow-up, surgical treatment is more often necessary. When using the UTD classification in the perinatal center, there is a high risk of underestimating the degree of dilatation due to the early conduct of the first ultrasound in the first two days of life.
Causes and nature of traumatic brain injury in a metropolis and the organization of assistance to victims in a multidisciplinary hospital
Authors: Dudanov I. P. , Podgornyak M. Yu. , Pavlov O. A. , Mitichkin M. S. , Verbitskii O. P. , Lazorkin V. A.
Published: December 2023

THE OBJECTIVE of the study was to study the causes and nature of traumatic brain injury in a metropolis and to form the principles of providing assistance to victims in a multidisciplinary hospital.

METHODS AND MATERIALS. The analysis of a sequential sample of 2017 case histories of patients admitted to St. Petersburg State Medical Institution “Mariinsky City Hospital” for urgent indications with injuries of the skin of the head, skull bones, brain of varying severity was carried out. They accounted for 69 % of the total number of injured patients (2,932 people) admitted with injuries to various parts of the body, including the head, from August 2021 to February 2022. We analyzed 114 case histories of patients treated in the intensive care unit (ICU). The mortality rate in this group was 36 % (41 out of 114 people). The work is illustrated by clinical observations with typical urban injuries, which were caused by icicles falling on the head, blocks of snow from the roofs of houses, incidents with personal mobility equipment on the sidewalks of the city, falls on ice and other causes.

RESULTS. Based on clinical examples, the causes and features of urban traumatic brain injury in a metropolis, criteria for sorting and routing patients admitted with signs of traumatic brain injury were considered.
Prevention of complications from the laparotomy wound in abdominal gunshot injury
Authors: Maistrenko N. A. , Sazonov A. A. , Romaschenko P. N. , Makarov I. A.
Published: December 2023

The OBJECTIVE was to evaluate the effectiveness of the original technique for assessing the reparative potential of the anterior abdominal wall in the prevention of complications from the laparotomic wound in abdominal gunshot injury.

METHODS AND MATERIALS. The comparative assessment of the results of surgical treatment of 145 victims with abdominal gunshot injury, which were divided into 2 groups, was made. The retrospective group included 92 patients who underwent a standard approach to the prevention of infectious complications in the surgical area: perioperative administration of antibiotics, daily dressings, as well as laboratory monitoring of acute phase parameters and instrumental assessment of tissue condition (ultrasound). The prospective group was formed from 53 patients in whom, as part of the prevention of the infectious process, the original method for assessing the reparative potential of the tissues of the anterior abdominal wall was used (priority certificate for the invention ¹ 2023109198 dated 04/12/2023). The studied groups were comparable in terms of the main clinical criteria: the age of the victims, the severity of injuries, and the structure of surgical interventions.

RESULTS. Suppuration of the laparotomic wound was noted in 22 patients in the retrospective group and in 4 in the prospective group, which accounted for 23.9 % and 7.5 % of their number (p=0.014). Eventration was observed in 11 patients in the retrospective group and in one patient in the prospective group (11.9 % and 1.9 %, p=0.05).

CONCLUSION. The use of the original technique for assessing the reparative potential of the tissues of the anterior abdominal wall makes it possible to reduce the incidence of complications from the laparotomic wound in abdominal gunshot injury.
The case of migration of a fragment of a Kirchner wire to the ascending aorta
Authors: Semenyuta V. V. , Rykov V. V. , Starkov E. P. , Morozova E. S. , Elmadzhi R. V. , Anisimov S. V. , Nazarov S. B. , Mykolnikov A. V.
Published: December 2023

Fracture and migration of fragments of a Kirchner wire is a rare but potentially dangerous complication after treatment of clavicle injuries. In the presented clinical case, the fracture of the Kirchner wire occurred 2 months after the fixation of the sternoclavicular joint. The fragment of the Kirchner wire migrated into the anterior mediastinum, penetrated into the ascending aorta with the formation of an anterior mediastinal hematoma and right-sided hemothorax. The fragment of the Kirchner wire was successfully extracted during the operation through median sternotomy. In this case, the Kirchner wire did not damage other structures and was extracted without the use of cardiopulmonary bypass.
Academician Viktor Sergeyevich Savelyev (1928–2013) (on the 95th anniversary of his birth)
Authors: Kurygin Al. A. , Semenov V. V.
Published: December 2023

Outstanding surgeon, scientist, teacher and organizer of healthcare, founder of a large surgical school, Hero of Socialist Labor (1988), academician of the USSR Academy of Medical Sciences (1974), RAMS (1991) and RAS (1997), laureate of the USSR State Prize (1975), the State Prize of the Russian Federation (1992), Demidov Prize (2002) and the A. N. Bakulev Prize (2002), Professor Viktor Sergeevich Savelyev was born on February 24, 1928 in the village of Pakhotny Ugol of the Bondarsky district of the Tambov region in the family of Sergei Dmitrievich Savelyev, a wood sawmill worker, and Olga Kuzminichna, a housewife. In 1945, Viktor Sergeevich entered the 2nd Moscow Medical Institute (now the Pirogov Russian National Research Medical University). After graduating in 1951, he studied in residency at the Department of Faculty Surgery, which was headed by the academician A. N. Bakulev, and was stayed at the department as an assistant. After defending his PhD thesis in 1955, he was appointed a teacher. In 1959, V. S. Savelyev successfully defended his doctoral dissertation, in 1961, he passed the academic title of Professor, in 1967, he was elected the head of the Department of Faculty Surgery. Viktor Sergeevich fully became the successor of A. N. Bakuleva and made the very great contribution to the development of domestic cardiac surgery. The works of V. S. Savelyev played a huge role in the formation and rapid development of vascular surgery. The clinic he headed has accumulated the world’s largest experience in the treatment of acute thrombosis and embolism of the main arteries. Viktor Sergeevich is rightfully one of the founders of modern Russian phlebology. He also made a significant contribution to the development of surgery of the stomach, intestines, bile ducts and pancreas. He was one of the first in the country to use organ-preserving operations on the stomach for complicated duodenal ulcer. Many of Viktor Sergeevich’s works were devoted to various aspects of postoperative management of patients, infusion therapy and parenteral nutrition, pathogenesis, diagnosis and treatment of sepsis. V. S. Savelyev and his students made a significant contribution to the development of abdominal endoscopy. V. S. Savelyev was a major organizer of domestic healthcare, for 34 years he held the post of the chief surgeon of the Ministry of Health of Russia. He was the Chairman of the Scientific Society of Surgeons of Russia (ROH), founder and president of the Russian Association of Phlebologists, editor-in-chief of journals «Thoracic and Cardiovascular Surgery» and «Phlebolymphology». Under his leadership and with his participation as the scientific consultant, 70 doctoral and 180 candidate dissertations were defended. He was the author and co-author of more than 500 scientific papers, including 24 monographs and manuals. The academician Viktor Sergeevich Savelyev died on December 25, 2013 and was buried in Moscow at the Troyekurovo Cemetery.
The correction of venous stasis in delayed breast reconstruction with a free tram-flap after mastectomy
Authors: Makarov I. V. , Kochetkov R. I. , Kasatkin S. E.
Published: December 2023

The presented case contains a successful surgical correction of venous stasis of an autograft that occurred in the early postoperative period during the delayed reconstruction of the left breast with a free TRAM flap in a patient after radical surgical treatment of stage 3A pT2N2M0 breast cancer. Using the microsurgical technique, two venous anastomoses were sequentially applied, which made it possible to keep the transplanted flap completely viable and, thus, to ensure a successful outcome of the reconstructive surgery.
Program for accelerated recovery of patients with esopha geal cancer after surgical treatment (literature review)
Authors: Dvoretsky S. Yu. , Kapshuk Ya. Yu. , Akopov A. L.
Published: December 2023

This review is devoted to new trends in esophageal surgery due to the introduction of ERAS (Enhanced Recovery After Surgery). Currently, the absence of a single regulation for the surgical treatment of patients with esophageal diseases requires the search for new directions and research in this area. However, any innovations always cause alertness among surgeons, which is associated with a high risk of postoperative complications and an increase in the mortality rate. The article discusses new reports proving the ineffectiveness of many established principles of treatment, and also demonstrates the importance of a multidisciplinary approach to the treatment of such patients.
Implementation of Prehospital Handover in the Emergency Department: A Proposed Novel SRCA Checklist in Saudi Arabia
Authors: Alsofayan ‏Yousef , Alomar ‏Ahlam , Alsuwayyigh ‏Abdulaziz , Alruthia ‏Yazed , Althunayyan ‏Saqer , Jan Taimour , Alsomali Mahmoud , Almatari Ali , Alhajjaj ‏Fahad , Alowais ‏Jalal
Published: December 2023

Background: Maintaining effective clinical handover between prehospital services and emergency departments is crucial to recognize critical cases, guiding proper management, and determining final outcomes.

Methods: This is a single-center cross-sectional study that was conducted between October 15, 2021, and July 30, 2022, in a tertiary care center in Riyadh, Saudi Arabia. A novel handover tool (SRCA checklist) was developed, and eight emergency medicine consultants checked its content validity. It contains 4 domains and 12 items and is based on previously validated tools after an extensive literature review and experts' opinions. The primary outcome of this study was to validate the newly developed tool aimed at assessing the quality of handover skills between prehospital medical care providers and emergency departments. The tool\'s reliability was examined using Cronbach\'s alpha method, while factor analysis with varimax rotation was used to examine the construct validity.

Results: 147 handovers were captured in this study. Almost 50% of the observed handovers adhered to 7 out of 12 checklist criteria for assessing the handover quality. The chief complaint and associated symptoms were reported in 94.56% (n=139) of cases, and verbalizing of the Airway–Breathing–Circulation–Disability–Exposure (ABCDE) was seen in 75% (n=111) of cases.
Memory studies i kino nostalgiczne
Authors: Włodek Patrycja
Published: December 2023

Artykuł koncentruje się na zagadnieniu memory studies, interdyscyplinarnych badań nad fenomenem pamięci indywidualnej i zbiorowej oraz relacji między nimi wzajemnie, przeszłością a teraźniejszością oraz kontekstem społecznym. Memory studies funkcjonują na przecięciu wielu różnorodnych dyscyplin, a w ramach filmoznawstwa ich egzemplifikacją mogą być choćby badania nad postmodernizmem filmowym, a zwłaszcza filmem nostalgicznym i modą retro, które zostają zdefiniowane i omówione na przykładach pochodzących z kina amerykańskiego lat siedemdziesiątych obrazujących strategie stosowane przez twórców definiujących i redefiniujących ekranowe reprezentacje przeszłości, kształtowane, ale też kształtujące, pamięć zbiorową.
„Ich habe einfach immer weitergemacht“
Authors: Steffen Markus
Published: December 2023

Vorgestellt wird die Prozessanalyse über 36 therapeutische Gespräche mit einer Klientin mit erschöpfungsbedingter Krise. Die Gespräche werden in drei Phasen eingeteilt, wovon jede mit einem kommentierten Gesprächsausschnitt illustriert wird. Als theoretischer Bezugsrahmen dient das klientenzentrierte Kriseninterventionsmodell von Brossi.
Persepsi Peternak terhadap Pengobatan Haemonchosis pada Domba dengan Serbuk Buah Mengkudu (Morinda citrifolia) di Desa Ngadirojo, Kecamatan Secang, Kabupaten Magelang
Authors: Purwo Widiarso Budi , Prihati Gesang Adil , Akimi
Published: December 2023

Penelitian dilakukan di Desa Ngadirejo, Kecamatan Secang, Kabupaten Magelang. Tujuan penelitian menganalisis persepsi peternak terhadap pengobatan haemonchosis pada domba menggunakan serbuk buah mengkudu (Morinda citrifolia) dan mengetahui hubungan karakteristik peternak terhadap persepsi peternak dalam pengobatan haemonchosis pada domba dengan serbuk buah mengkudu (Morinda citrifolia). Desain kajian yang digunakan yaitu one-shot case study, menggunakan 35 responden dipilih mengunakan metode sensus. Analisis data yang digunakan adalah analisis deskriptif dan analisis regresi linear berganda. Variabel dalam kajian ini terdiri dari variabel independen yaitu faktor internal umur, tingkat pendidikan, pengalaman beternak dan faktor eksternal intensitas penyuluhan serta variabel dependen yaitu persepsi peternak. Hasil analisis menunjukkan bahwa persepsi peternak terhadap pengobatan haemonchosis pada domba menggunakan serbuk buah mengkudu (Morinda citrifolia), dalam kategori baik yaitu dengan nilai sebesar 2831 dan rata rata 80,89. Berdasarkan uji analisis statistik regresi linier berganda variabel umur, tingkat pendidikan, pengalaman beternak dan intensitas penyuluhan secara simultan atau bersamaan memiliki pengaruh sangat signifikan (P<0,01) terhadap persepsi peternak. Secara parsial atau individu variabel umur, pendidikan dan pengalaman beternak berpengaruh signifikan dengan persepsi peternak (P<0,05) sedangkan untuk intensitas penyuluhan berpengaruh tidak signifikan dengan persepsi peternak (P>0,05).
Inovasi Penerapan Dan Faktor Pendukung Agribisnis Hortikultura
Authors: Idawati  , Sasongko Nugroho Adi , Suryanti Reni , Haryanto Yoyon , Rosnina  , Haruna Naima
Published: December 2023

Konsep industrialisasi pertanian perdesaan merupakan konsep pembangunan yang mencerminkan kesatuan industri pertanian yang terintegrasi dengan output berupa produk yang memiliki nilai tambah ekonomi yang besar. Tujuan penelitian adalah (1) Mendeskripsikan kegiatan agribisnis hortikultura pada subsektor hilir agribisnis hortikultura yang telah dilakukan petani (2) Menganalisis tingkat penerapan inovasi industrialisasi pertanian hortikultura pedesaan (3) Menganalisis pengaruh faktor kegiatan subsektor hilir dan penerapan industrialisasi pertanian pedesaan. Metode penelitian meliputi analisis kuantitatif dan kualitatif. Populasi penelitian petani hortikultura sebanyak 30 responden yang dilakukan secara purposive pada kelompok Bakti Mandiri di Desa Sukajadi. Penentuan sampel dilakukan secara sensus terhadap 30 orang anggota kelompok Bakti Mandiri yang menjalankan agribisnis hortikultura. Pengumpulan data dilakukan dengan cara purposive sampling melalui wawancara dengan menggunakan kuesioner. Analisis data menggunakan deskriptif kualitatif berupa persentase dan regresi berganda untuk menggambarkan kegiatan subsektor hilir, tingkat penerapan IPP dan faktor-faktor yang mempengaruhinya. Hasil penelitian menunjukkan bahwa (1) Pemasaran disusun oleh kelompok dengan penjualan langsung ke pedagang pengumpul, kemudian dijual kembali ke pengecer di pasar sentral. (2) Ciri inovasi penerapan industrialisasi pertanian pedesaan dengan pemanfaatan tempat, waktu dan kepemilikan pada fungsi pemasaran sudah berjalan dengan baik, sedangkan secara perubahan bentuk (pengolahan) belum terlaksana. (3) Dukungan penyuluhan berkontribusi dalam pelaksanaan industrialisasi pertanian pedesaan. Penerapan industrialisasi pertanian pedesaan dalam kondisi optimal terutama swadaya melalui ketua kelompok tani.
Chatbots, generative AI, and scholarly manuscripts
Authors: Zielinski Chris , Winker Margaret A. , Aggarwal Rakesh , Ferris Lorraine E. , Heinemann Markus , Lapeña Jr Jose Florencio , Pai Sanjay A. , Ing Edsel , Citrome Leslie , Alam Murad , Voight Michael , Habibzadeh Farrokh
Published: December 2023

This statement revises our earlier “WAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications” (January 20, 2023). The revision reflects the proliferation of chatbots and their expanding use in scholarly publishing over the last few months, as well as emerging concerns regarding lack of authenticity of content when using chatbots. These recommendations are intended to inform editors and help them develop policies for the use of chatbots in papers published in their journals. They aim to help authors and reviewers understand how best to attribute the use of chatbots in their work and to address the need for all journal editors to have access to manuscript screening tools. In this rapidly evolving field, we will continue to modify these recommendations as the software and its applications develop.
Laparoscopic liver resections: a descriptive study of our 16-year experience
Authors: Alesandrini Agustín A. , Bersano Fernanda V. , Statti Miguel A. , Canepa Mukdise Enrique
Published: December 2023

Background: Improvements in laparoscopic surgery have led to more rapid progress in laparoscopic liver resections. The indications of this approach are still matter of debate. Objectives: The aim of the present study is to describe the results obtained in series of patients undergoing laparoscopic liver resections. Material and methods: We conducted a descriptive, observational and analytical study. We evaluated a series of patients undergoing laparoscopic liver resection categorized by Iwate criteria between January 2005 and October 2021. The demographic variables, diagnosis, type of approach, intraoperative findings, clinical and technical aspects and complications, were analyzed. Results: Of 159 patients undergoing hepatectomies, 120 procedures were performed laparoscopically (applicability rate 75%) and were divided into four groups according to the Iwate scoring system: low (difficulty index 0–3), 23 patients (19%); intermediate (difficulty index 4–6), 48 patients (40%); advanced (difficulty index 7–9), 33 patients (28%); and expert (difficulty index 10–12). 16 patients (13%). Median age was 62 years. The rate of Clavien-Dindo complications ≥ grade 3 was 14.28% and mortality rate was 2.5%. In resections of colorectal liver metastases disease-free survival was 75%, 59%, 46% at 1, 3 and 5 years, respectively, and overall survival was 93%, 79% and 69%, at 1, 3 and 5 years, respectively. Conclusions: Laparoscopic liver resection resulted a feasible and safe technique and should be performed by trained surgeons, in specialized centers and with long learning curves to increase the applicability rate from the simplest resections to the most complex ones. Careful selection of patients is required to ensure their safety.
Editorial
Authors:   Director Revista, Montesinos Manuel R.
Published: December 2023

As we mentioned in 2020 for its 60th anniversary, the Journal continues to achieve its foundational objectives: ensuring an adequate circulation of surgical knowledge through a rigorous selection of articles, with an educational purpose for authors and readers1. Nowadays, surgical knowledge has become increasingly complex and voluminous due to the introduction of new techniques and the fact of managing a greater amount of information.
Heidegger and Plato's idea of the Good
Authors: Gaginskii Aleksei Mikhailovich
Published: December 2023

The article deals with the question of Plato's reception in Heidegger's philosophy. In particular, the research focuses on the question of how Heidegger interpreted the idea of the good from Plato's "State". Here a number of difficulties important for the history of philosophy arise. What is the ontological status of the idea of good? How is the idea of the good connected with the demiurge from the dialogue "Timaeus"? On the one hand, it is well known that the late Heidegger criticized Plato and all European metaphysics, which was and remains Platonism. On the other hand, the early Heidegger clearly presents an attempt to master the shining heights of Platonism: the question of the meaning of being needs an angle from which a definite answer can be highlighted – and Heidegger borrows this angle from Plato. Just as the good endows existence with being and truth, so the understanding of being is possible from time, because it is temporality that is the condition for understanding being, it highlights its meaning. And if Plato's being "pounces" on the good, or on the one, then for Heidegger, time is such a condition. This line of thought, fundamental to the whole project of fundamental ontology, is directly related to the philosophy of Plato, who for the first time was able to rise so high as to become ἐπέκεινα τῆς οὐσίας, to see things as if from the outside, i.e. in the light of the transcendent idea of good. Nevertheless, Heidegger criticizes Plato, which allows us to raise the question: how did Heidegger understand Platonic ἐπέκεινα τῆς οὐσίας and the doctrine of the good? It is impossible to answer this question unequivocally, since Heidegger approached this question from different sides and at different times interpreted this most important position of the Greek thinker in different ways. Nevertheless, the main remarks can be reduced to two: (1) the good was conceived by Plato as something moral and therefore mixed with the existing, (2) the good subordinates the being, brings it under fitness.
Perbandingan Pengaruh Latihan Ladder In Out Dengan 40-yard Lateral Shuffel Terhadap Peningkatan Kelincahan
Authors: Rahmawan Dani , Maryati Sri , Nursasih Isna Daniyati
Published: December 2023

This study aims to determine the increase in agility. The research method uses a pre-experimental design. The population used was the male students of MTs Negeri 1 Pangandaran who took part in volleyball extracurricular activities, totaling 30 people. The sampling technique used was the total sampling technique. The test instrument or measuring tool used is the shuttle run test. Based on data analysis using SPSS series 24, the results of data processing consist of 1. Ladder-in-out exercises have a significant effect on increasing body agility in students of MTs Negeri Pangandaran. The 40-yard lateral shuffle exercise has a significant effect on increasing body agility in MTs Negeri Pangandaran students. 3. There is no significant difference in the effect of the ladder in out exercise and the 40-yard lateral shuffle exercise on increasing body agility in students of MTs Negeri Pangandaran. Conclusion: Ladder in-out exercise with 40-yard lateral shuffel exercise to increase body agility in students of MTs Negeri Pangandaran.
Pengaruh Latihan Explosive Push-up Dengan Drop and Catch Push-up Terhadap Peningkatan Daya Tahan Otot Lengan
Authors: Romdoni Doni , Sutisna Nana , Rustiawan Hendra
Published: December 2023

The perseverance of the arm muscles that are focused on changes in the increment that comes from the impact of hazardous push-ups and drop and catch push-ups. Balebat Volleyball Club, Kawali Locale, Ciamis Regime is the exploration area. There are 20 players who are utilized as exploration objects. The exploration strategy applied is the free trial plan. The estimation apparatus utilized is push-ups. The outcomes got are: 1. Unstable push-up preparation fundamentally affects positive changes in arm muscle perseverance of Balebat Volleyball Club understudies, Kawali Locale, Ciamis Regime. 2. The drop-and-catch push-up practice fundamentally affects positive changes to the arm muscle perseverance of understudies of the Balebat Volleyball Club, Kawali Locale, and Ciamis Regime. 3. There is a massive contrast between dangerous push-ups and drop-and-catch push-ups for positive changes in arm muscle perseverance. Conclusion. There are contrasts in certain progressions from the impact of hazardous push-ups and drop and catch push-ups on muscle perseverance information on the ITH segment.
Potential Maternal Risk Factors for Low Birth Weight in Indonesia: A Systematic Review
Authors: Nurwati Yuni , Hardinsyah Hardinsyah , Marliyati Sri Anna , Santoso Budi Iman , Anggraini Dewi
Published: December 2023

This review was conducted with the aim of summarizing the articles on the potential maternal risk factors for Low Birth Weight (LBW) in Indonesia. All observational studies conducted in Indonesia between 2010 and 2022 were thoroughly reviewed in this study. The articles were retrieved from "PubMed", "ScienceDirect", "Web of Science", and "Garuda". The retrieval was supplemented by snowball sampling technique. This review was constructed according to the PRISMA guidelines and the quality of the articles was assessed according to the STROBE guidelines. Of the 129 articles, only 12 articles met the inclusion criteria. Maternal variables such as education (50%), household wealth (33.3%), nutritional status (33.3%), age (25%), pregnancy complications (25%), marital age (16.7%), gestational weight gain (16.7%), ANC visit (16.7%), weight at third trimester (16.7%), twin birth (16.7%), birth interval (16.7%), iron supplementation (8.3%), parity (8.3%), and anemia status (8.3%) were found to be the risk factors for LBW incidence. This review found that almost all potential maternal risk factors contributing to LBW are preventable. It may help policy makers to design a more effective LBW prevention intervention and early risk identification for pregnant women. Appropriate follow-up by health workers for clinical intervention will also help to improve their pregnancy outcomes.
Validation of a Questionnaire on Knowledge and Barriers of Breast Milk Expression among Mothers of Premature Infants
Authors: Wan Nor Wan Haiera , Mohamad Noraini , Saddki Norkhafizah , Mat Yudin @ Badrin Zainab , Tengku Ismail Tengku Alina , Sulaiman Zaharah , Ibrahim Nor Rosidah
Published: December 2023

This study aimed to develop and validate a Malay language questionnaire to assess mothers' knowledge in providing breast milk for premature infants, and barriers to breast milk expression while the infants are in the Neonatal Intensive Care Unit (NICU). Two tertiary hospitals in Kelantan, Malaysia participated in this cross-sectional study. Relevant items of knowledge and barriers were identified through a literature search, clinical observations, and expert opinion. Ten breastfeeding experts validated the content of the knowledge and barriers to breast milk expression questionnaire.The effectiveness of the questionnaires was tested for face validity among ten mothers, followed by reliability tests comprising 50 mothers who gave birth prematurely. The 20 knowledge items and 16 barrier items have an Item-level Content Validity Index (I-CVI) of 0.99, indicating good relevance of the knowledge and barrier items. The knowledge and barrier questionnaires had Item-level Face Validity Indexes (I-FVIs) of 1.00 and 0.99, respectively, suggesting clear and comprehensible items. The questionnaires obtained a Cronbach alpha score of 0.726 for knowledge and 0.736 for barriers, showing that they are reliable tools for assessing knowledge and breast milk expression barriers. The validity and reliability of the newly developed Malay version of the questionnaire have been established for evaluating breastfeeding knowledge and barriers to expressing breast milk among mothers with premature infants.
Geophagia in Nigeria: Perceptions and Practices of Pregnant Mothers versus Possible Health Outcomes
Authors: Onyenweaku Eridiong Ogbonna
Published: December 2023

This study aimed at ascertaining the perceptions and practices of pregnant mothers on geophagia, as well as highlighting possible health outcomes. For the cross-sectional survey, a structured questionnaire was designed, content-validated by experts, pre-tested and used for data collection. The questionnaires were administered to 200 pregnant mothers at health care facilities in southern Nigeria (particularly in Calabar and Onitsha), who consented to be part of the study. The findings of this study show that about 75% of the pregnant mothers admitted to consuming edible clays both during and after pregnancy with 60% of them stating that it was a safe practice during pregnancy. Also, the results show that income level and educational attainment significantly (p<0.05) influenced the perception and practices of the respondents regarding geophagia. Of the 2 edible clays explored in this study, kaolin clay was more popularly consumed than bentonite clay. With regards to respondents’ health status, none of them admitted to developing anaemia or any chronic disease during pregnancy. In conclusion, edible clays are still commonly consumed by women in Southern Nigeria, irrespective of age and exposure. Scientific reports show that these clays contain appreciable amounts of certain anti-nutrients and heavy metals, hence it is necessary to create awareness on the possible dangers related to their increased consumption, particularly during pregnancy.
Hands-on neuroendovascular practice for nonselective undergraduate medical students increases interest and aspirations in pursuing neurosurgery as a specialization
Authors: Michiwaki Yuhei , Yamane Fumitaka , Itokawa Hiroshi , Tanaka Tatsuya , Shimoji Kazuaki , Matsuno Akira
Published: December 2023

Background:

The number of medical students aspiring to become neurosurgeons has decreased worldwide, mainly due to poor work-life balance among neurosurgeons; therefore, recruiting students for neurosurgery is essential to ensure the availability and appropriate quality of neurosurgical treatment. This study aimed to evaluate the efficacy of hands-on neuroendovascular practice for nonselective undergraduate medical students to determine whether this increases their interest in neurosurgery and contributes to their aspirations of becoming neurosurgeons.

Methods:

Hands-on neuroendovascular practice for mechanical thrombectomy was performed by undergraduate 5th-year medical students during their 2-week clinical rotation in the Department of neurosurgery at our university hospital between April 2021 and March 2023. After the neurosurgery practice, a questionnaire about their understanding of neurosurgery and aspirations for this specialization before and after the practice was anonymously completed by all students.

Results:

Overall, 153 students completed the questionnaire. Of these, 140 (91.5 %) showed increased interest in neurosurgery after participating in the hands-on practice. Through this practice, the number of students who considered neurosurgery as their first choice or one of their specialty choices increased from 8 (5.2%) to 12 (7.8%) (P= 0.3534) and from 19 (12.4%) to 52 (34.0%) (P< 0.0001), respectively. Furthermore, the number of students with no aspiration to become neurosurgeons decreased from 95 (62.1%) to 43 (28.1%) (P< 0.0001).

Conclusion:

Hands-on neuroendovascular practice for nonselective undergraduate medical students effectively increased their interest in neurosurgery specialization and their desire to become neurosurgeons. Therefore, this practice can help recruit medical students for neurosurgery specialization.
A Case Study on Personalized Art Education for Learners with Developmental Disabilities
Authors:   Society for Art Education of Korea, PARK Jinhee , KIM Sunah
Published: December 2023

Personalized learning is increasingly in demand to meet the diversity of learners in education field. Therefore, this study aimed to explore and analyze personalized art education plans for learners with devel-opmental disabilities, through cases that respects their diversity in terms of characteristics, levels, needs, and aptitudes. The following research results were derived from the case of this study, which applied a cyclical process of learner understanding, learner-centered curriculum design, learner-led lesson im-plementation, process-centered assessment, and communication and reflection of learning outcomes, cen-tering learners as the subject who lead the lesson and as a source of information. First, personalized art education, which prioritizes understanding of learners, can be useful for disabled learners with a wide range of individual diversity as well as disability types and characteristics. Second, art education can en-able meaningful learning by respecting the world they express with their own unique visual language. Third, various and continuous process-centered assessment methods can prevent disabled learners from receiv-ing unreasonable grades. Personalized art education for disabled learners requires a system and support to design and utilize level-based and overall curriculum, beyond the concerns and efforts of individual teachers. Future research should focus on the methodology of art education that respects the diversity of learners and ways to materialize personalized art education.
A Study on the Direction of Future Art Education: An Aesthetic Experience in Art Curriculum
Authors:   Society for Art Education of Korea, RYU Jiyeong
Published: December 2023

The purpose of this paper is to pursue art educational meaning and direction of future by understanding aesthetic experience in the aesthetic practice of human beings who encounter art. I regard art as a prac-tice or act rather than a specific object, incident or thing. I hope to further clarify its aesthetic significance and its perspective on the educational aspect. Today, art is a culture that has unique characteristics that distinguish it from other academic disciplines such as society, politics, and economics, and it serves to broaden the horizon of understanding of the nature of the human spirit. Examine human aesthetic practice based on experience with art, and examine the meaning and character of 'aesthetic' as an educational ac-tivity of human beings surrounding art, treating art as a kind of human practical form as visual art. Aesthetic experience is the practice in which the object and the subject communicate with each other vigorously, and the practice is not a passive process of accepting the aesthetic attributes of the object, but a concrete practice. Aesthetic experience is differentiated from everyday human practice and has the power to re-flectively reflect on history and society, the world and myself. Through such aesthetic experiences, practical forms of aesthetic situations can be discovered and educational outcomes that are meaningful to human beings can be derived.
"France bouge". Et la Suisse ? Réflexion sur des formes linguistiques différentes de publicités françaises et suisses utilisant l'argument national
Authors: Genoud Isabelle
Published: December 2023

[pas de résumé]
Effect of Interfacial Potential on Elementary Exciton Processes in InP-based Core/shell Quantum Dots
Authors: Inada Kazuki , Eguchi Daichi , Tamai Naoto
Published: December 2023

Suppression of Auger recombination rate in semiconductor quantum dots (QDs) is essential for various applications such as LEDs and lasers. We investigate the effect of interfacial potential on Auger recombination processes in InP-based core/shell quantum dots (c/s QDs) using femtosecond transient absorption spectroscopy (fs-TAS). We have synthesized c/s QDs with diverse interfacial potentials: steep ones (InP/ZnS and InP/ZnSe QDs) and a smoothed counterpart (InP/ZnSexS1-x/ZnS QDs). The steady-state absorption and luminescence spectra obtained from aliquots extracted during the synthesis of InP/ZnSexS1-x/ZnS QDs and the EDS line profile revealed the formation of a compositional gradient shell (smoothed interfacial potential). The Auger recombination processes in InP/ZnSexS1-x/ZnS QDs QDs were ~ 8 times slower than those in InP/ZnS QDs in the same volume. These suppressions can be explained by the effective electron wavefunction penetration from the core into the shell and reduced carrier momentum in the final state resulted from the smoothed interfacial potential. These findings provide an important guideline for the rational design of the interfacial potentials in InP-based c/s QDs for various applications such as LED and laser devices.
Encoding prior knowledge in ensemble refinement
Authors: Köfinger Jürgen , Hummer Gerhard
Published: December 2023

The proper balancing of information from experiment and theory is a long-standing problem in the analysis of noisy and incomplete data. Viewed as a Pareto optimization problem, improved agreement with the experimental data comes at the expense of growing inconsistencies with the theoretical reference model. Here, we propose how to set the exchange rate a priori to properly balance this trade-off. We focus on gentle ensemble refinement, where the difference between the potential energy surfaces of the reference and refined models is small on a thermal scale. By relating the variance of this energy difference to the Kullback-Leibler divergence between the respective Boltzmann distributions, one can encode prior knowledge about energy uncertainties, i.e., force-field errors, in the exchange rate. We highlight the relation of gentle refinement to free energy perturbation theory. A balanced encoding of prior knowledge increases the quality and transparency of ensemble refinement. Our findings extend to non-Boltzmann distributions, where the uncertainty in energy becomes an uncertainty in information.
Long-lasting Cross-linked PLGA-Inspired Nanoparticles from One-pot Nanopolymerization of Precisely Sequenced Short Oligolactoglycolic Acid Dimethacrylates
Authors: Blagojevic Luka , Kamaly Nazila
Published: December 2023

Poly(lactic-co-glycolic acid) (PLGA) is a widely utilized polymer for biomedical applications due to its biocompatibility and degradability in vivo. Traditional methods of fabrication of drug-loaded nanoparticles (NPs) employ the random sequence form of linear PLGA to yield non-crosslinked polymeric NPs that form when the polymer nanoprecipitates out of solution. Given the large-scale use of PLGA-based polymeric drug delivery systems to date, it is crucial to be able to control the ratio and sequence of lactic and glycolic components in the overall drug delivery system, which in turn can impact factors such as stability, drug loading, drug release and degradability. In this work, we present a novel PLGA-inspired NP polymerization technique, which allows the formation of NPs via the cross-linking of precisely sequenced short oligolactoglycolic acid dimethacrylates (OLGADMAs). Following the synthesis of a range of OLGADMAs we successfully generated a library of NPs via this rapid and surfactant-free nanopolymerization method, which permits the simultaneous NP formation and encapsulation of drugs such as dexamethasone. Our results indicate that NPs produced through this nanopolymerization technique with precisely controlled sequences exhibit heightened stability compared to conventionally sequenced and non-sequence controlled PLGA, as evidenced by minimal pH changes over a five-week span. This improved stability is attributed to simultaneous crosslinking and co-polymerization of the OLGADMAs. Moreover, the long-acting NPs demonstrated minimal cytotoxicity and uniform cellular uptake in vitro. We conclude that the ability to precisely regulate the sequence of short PLGA-inspired monomers and employ a unique in situ nanopolymerizing reaction results in exceptionally stable NPs for sustained drug delivery and opens exciting possibilities for the development of a range of long-lasting drug delivery systems with programmable structure and function.
Time resolved photoelectron spectroscopy of iodide-4-thiouracil cluster: the pi/pi star state as a doorway for electron attachment
Authors: Asplund Megan , Koga Masafumi , Wu Ying Jung , Neumark Daniel
Published: December 2023

The photophysics of thiobases — nucleobases in which one or more oxygen atoms are replaced with sulfur atoms — have been shown to vary greatly depending on the location of sulfonation. Not only are direct dynamics of the neutral thiobase impacted, but also the dynamics of excess electron accommodation. In this work, time resolved photoelectron spectroscopy (TRPES) is used to measure binary anionic clusters of iodide and 4-thiouracil, Iˉ4TU. We investigate charge transfer dynamics driven by excitation at 3.88 eV, corresponding to the lowest ππ* transition of the thiouracil, and 4.16 eV, near the cluster vertical detachment energy. The photoexcited state dynamics are probed by photodetachment with 1.55 eV and 3.146 eV pulses. Excitation at 3.88 eV leads to signal from the valence-bound ion only, indicating a charge accommodation mechanism that does not utilize the dipole-bound anion as an intermediate. Excitation at 4.16 eV rapidly gives rise to dipole-bound and valence-bound ion signals, with a second rise in valence-bound signal corresponding to the decay of the dipole-bound signal. The dynamics associated with the low energy ππ* excitation of 4-thiouracil provide clear experimental proof for the importance of localized excitation and electron backfilling in halide-nucleobase clusters.
Organocatalytic Enantioselective Nucleophilic Addition of Indole Imine 5-Methides
Authors: Li Yuxuan , Huang Jing , Han Zhengyu , Huang Hai , Hong Biqiong , Sun Jianwei
Published: December 2023

Despite the enormous developments in the asymmetric transformations of indole imine methides (IIMs), the remote asymmetric induction involving IIMs remains challenging due to the spatial interaction requirement between the substrate and catalyst. Herein we report the first catalytic asymmetric nucleophilic addition to indole imine 5-methide (5-IIM), the only topological isomer of IIMs whose asymmetric addition remains unknown. Considering the challenging remote stereocontrol, high efficiency and respectable enantioselectivity were achieved, providing access to a range of enantioenriched indole-containing triarylmethanes.