bluuebunny/crossref_metadata_2025 huggingface dataset:
A CRITICAL STUDY ON THE CONTROVERSY OF ABHIDHAMMA ACCORDING TO HISTORICAL AND TRADITIONAL APPROACH
Authors: Medhacitto Tri Saputra
Published: August 2024

ABSTRACT
This research provides a critical examination over the controversy surrounding the history of Abhidhamma based on historical background and written tradition. It is a library research which was done by collecting and scrutinizing data from the Tipitaka and its commentaries, combined with articles and books written by Buddhist scholars. Abhidhamma which is traditionally understood as higher teaching taught by the Buddha, reveals controversies among Buddhist scholars. They questioned the historical authenticity of Abhidhamma as the words of the Buddha, since they found several incompatibilities when looking at the historical background of the development of Buddhist literature. Kathāvatthuppakaraṇa, one of the seven books of Abhidhamma Piṭaka, is strong evidence that the book was compiled by Ven. Mogaliputtatissa Thera in the end of the third Buddhist council long after the parinibbāna of the Buddha. However, the written tradition as reported in the commentaries asserts that Abhidhamma should be accepted as Buddhavacana. Bhikkhu Buddhaghosa Thera in his commentaries consistently tried to highlight the Abhidhamma as higher teachings that should be acknowledged as Buddhavacana. This research sheds light on how the history of Abhidhamma is perceived on through the lenses of history and written tradition.
RELIGIOUS NATURALISM IN CHAN BUDDHISM WITH SPECIAL REFERENCE TO THE BLUE CLIFF RECORD
Authors: Wang Baoyu , Beliatte Metteyya
Published: August 2024

This paper delves into the interplay of religious naturalism and Chan Buddhism, emphasizing its manifestation within the Blue Cliff Record. Beginning with a contextualization of the research, the study identifies a gap in the comprehension of naturalism in this seminal text. Religious naturalism is conceptualized as the belief in nature's entirety, negating the need for the supernatural. By comparing religious naturalism with Buddhist tenets, parallels emerge, particularly the shared accentuation on nature, experiential understanding, and non-dualism. The Blue Cliff Record, a creation under Chan Master Yuanwu Keqin from the Song Dynasty, emphasizes tenets such as the renunciation of attachments and the appreciation of inherent Buddha-nature. A significant portion of the analysis is dedicated to the portrayal of flowers within the text, symbolizing principles harmonious with religious naturalism, including simplicity and self-realization through lived experiences. The dissertation concludes by revisiting its objectives, accentuating the nuanced differences between religious naturalism and Chan Buddhism, and emphasizing the potential for future interdisciplinary dialogues and research.
PENERAPAN KEPEMIMPINAN TRANSFORMASIONAL DALAM MENDUKUNG EFEKTIVITAS KINERJA ORGANISASI
Authors: Muhammad Arief Rachman  , Dewi Kurniawati
Published: August 2024

Kepemimpinan memiliki peran yang besar dalam memajukan dan mendukung kinerja sebuah organisasi. Dalam praktiknya, suatu organisasi akan berjalan dengan lebih baik dan terarah apabila mendapat dukungan penuh dari seorang pemimpin. Pemimpin dalam sebuah organisasi berperan dalam merumuskan visi, misi dan sasaran organisasi. Selain itu, pemimpin juga berperan dalam menentukan berbagai macam strategi pencapaian dari target organisasi serta mampu mengarahkan anggota-anggotanya dalam upaya pencapaian tujuan organisasi tersebut. Metode penelitian yang digunakan adalah kualitatif melalui studi pustaka (library research). Teknik pengumpulan data yang digunakan adalah dengan cara menghimpun dan menganalisis segala hal baik dari buku, artikel, maupun jurnal yang membahas terkait dengan komunikasi organisasi dan kepemimpinan. Berdasarkan hasil penelusuran yang telah dilakukan oleh penulis, maka didapati bahwa kepemimpinan transformasional sangat berperan penting dalam mendukung kinerja sebuah organisasi.
PENGARUH IKLIM KOMUNIKASI ORGANISASI TERHADAP PENINGKATAN KINERJA APARATUR SIPIL NEGARA
Authors: Pasaribu T B Reinhard , Dewi Kurniawati
Published: August 2024

Iklim komunikasi menjadi unsur yang penting dalam kegiatan organisasi terutama pada organisasi pemerintahan.  Perubahan iklim komunikasi organisasi ini dapat memengaruhi kinerja dan produktivitas Aparatur Sipil Negara (ASN). Artikel ini membahas pengaruh iklim komunikasi organisasi terhadap peningkatan kinerja ASN. Metode yang digunakan pada penulisan artikel ini adalah metode kualitatif melalui studi referensi (reference study). Berdasarkan hasil analisis yang dilakukan oleh penulis ditemukan bahwa iklim komunikasi organisasi memiliki pengaruh yang signifikan terhadap peningkatan kinerja pegawai sehingga diperlukan iklim komunikasi yang kondusif yang berarti aman dan terkendali untuk mendukung peningkatan kinerja pegawai.
ANALISIS PERSONAL BRANDING PRATAMA ARHAN MELALUI MEDIA SOSIAL INSTAGRAM PADA AKUN INSTAGRAM @Pratamaarhan8
Authors: Faikoh Faikoh Umairoh
Published: August 2024

Global trends are marked by the presence of social media. One of them is Instagram which can be used as a place to build a person's personal branding. In this research, personal branding is also a very important part for athletes, especially the U-23 Pratama Arhan national team soccer players. This research aims to determine Pratama Arhan's personal branding through the social media Instagram and the interactions that occur therein through the features on Instagram. This research is descriptive qualitative in nature with the main key informant being the Instagram account @pratamaarhan8. Data collection was carried out by documenting interviews with followers and literature studies related to personal branding. Researchers tried to analyze the social media account instagram@pratamaarhan8 in building personal branding with eight concepts coined by Peter Montoya, namely: Specialization, Leadership, Personality, Difference, Visibility, Unity, Firmness, good name. The results of this research, Pratama Arhan succeeded in building  personal branding through his Instagram social media by utilizing several features on Instagram and the eight personal branding concepts coined by Peter Montoya.
PROBLEMATIKA ETIKA KOMUNIKASI PRIVASI PADA FILM "UNLOCKED" TAHUN 2023
Authors: Mulzakir  , Syafruddin Pohan  , Al Hafizh M  , Eliza Dwi Anggraeni
Published: August 2024

Penelitian ini bertujuan untuk menginvestigasi representasi dan dilema etika komunikasi privasi dalam film Korea "Unlocked," yang populer di platform streaming Netflix. Dalam cerita yang intens dan menegangkan, film ini mengisahkan Lee Na Mi, seorang pekerja kantor biasa,yang kehilangan ponselnya dan harus berhadapan dengan konsekuensi serius ketika ponselnya diretas oleh Oh Jun Yeong, seorang peretas psikopat. Pendekatan penelitian menggunakan metode analisis semiotika Roland Barthes dan analisis konten untuk mengidentifikasi elemen-elemen semiotik dalam film yang berkaitan dengan etika komunikasi privasi, melalui 3 tahapan yaitu denotasi, konotasi dan Mitos. Peneliti mengumpulkan 9 adegan dari film ini yang menggambarkan pelanggaran Komunikasi Privasi. Hasil penelitian mengungkap bagaimana film ini menggunakan tanda-tanda visual, dialog, dan narasi untuk menyampaikan pesan-pesan kompleks tentang hak privasi individu dalam era digital yang semakin canggih. Ditemukan 6 poin pelanggaran privasi, yaitu: 1). penyerahan sandi pengguna ponsel pribadi dengan alasan kebutuhan perbaikan ponsel, 2). pemasangan kamera dan aplikasi ilegal pada ponsel tanpa izin yang digunakan untuk menguntit aktivitas keseharian 3). peretasan data pribadi mulai dari kode pengaman pintu rumah, PIN ATM hingga sandi media, 4). memasuki rumah korban peretasan tanpa izin 5). Mengambil uang dari ATM orang lain tanpa izin, 6). berpura-pura menjadi orang lain dan melakukan provokasi dengan mengunggah informasi palsu.
SURROGACY: THE LEGISLATION OF THE RUSSIAN FEDERATION AND THE KINGDOM OF SPAIN
Authors: KLENIKOVA A.V. , VIADER D.
Published: August 2024

The article analyzes the legislation of the Russian Federation and the Kingdom of Spain regulating registration of surrogacy. The legal problems of registering children in Spain born to a surrogate mother in another state are highlighted. The author focuses on the European practice of recognizing paternity and motherhood of genetic parents in order to ensure the child interests. However, Western countries require a court decision of the country in which the child was born in favor of the genetic parents, which contradicts the family legislation of the Russian Federation.
ANALISIS PROSES REKRUTMEN, SELEKSI KARYAWAN, DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN PT. ANHONG MEDIA INTERNATIONAL
Authors: Christon Christon , Saputra Asron
Published: August 2024

This study aims to investigate the influence of the recruitment process, employee selection, and work discipline on employee performance at PT. Anhong Media International in Kota Batam. Employing a quantitative approach, the research utilized a saturated sampling technique, involving the entire population of 107 individuals working at PT. Anhong Media International, located at di Kompleks Pertokoan Gading Mas, Sungai Panas Kota Batam, Kepulauan Riau. Data collection was conducted through an online questionnaire employing a Likert scale. The collected data underwent comprehensive analysis using SPSS 26, encompassing descriptive statistical tests, data quality assessments, classical assumption tests, influence tests, and hypothesis testing. The multiple linear regression results revealed that the recruitment process (X1) holds a significant 25.8% impact on employee performance (Y1), employee selection (X2) influences employee performance (Y1) by 17.9%, and work discipline (X3) contributes to employee performance (Y1) by 25.5%. The combined effect of the recruitment process, employee selection, and work discipline on employee performance at PT. Anhong Media International is determined to be 25.8%, as indicated by the coefficient of determination (R2).
Modelagem computacional baseada em Dinâmica de Sistemas do processo de qualificação da gestão do SUS em saúde bucal
Authors: Umeda Josely Emiko , Passos Guttenberg Ferreira , Uchida Tânia Harumi , Tsuzuki Fernanda Midori , Lolli Luiz Fernando , Pucca Junior Gilberto Alfredo , Fujimaki Mitsue
Published: August 2024

Este estudo teve como objetivo apresentar uma modelagem computacional baseada em Dinâmica de Sistemas (DS) para avaliar a estimativa de qualificação profissional dos participantes do “Curso de Qualificação da Gestão do SUS em Saúde Bucal” do Paraná. O formulário de inscrição Google Drive foi utilizado para a coleta de dados quanto ao número de profissionais de saúde participantes dos 4 ciclos do Curso. Os dados foram tabulados em planilhas do Excel® e aplicados na modelagem DS utilizando o Programa Vensim DSS 6.3. A validação foi realizada com a análise de sensibilidade de 50.000 simulações, considerando 3 situações: cenário real de participação no Curso, melhor cenário (20% acima do real) e pior cenário (20% abaixo do real). Os resultados apontaram para o aumento exponencial de conhecimentos dos participantes ao alcançar o último ciclo. A análise de sensibilidade de 50.000 simulações demonstrou que a modelagem proposta foi consistente e robusta. Conclui-se que a modelagem DS foi adequada e as capacitações permanentes dos profissionais de saúde em formato de onda formativa do curso ao longo dos ciclos contribuíram para o crescimento exponencial do conhecimento.
Avaliação de custos e eficiência de meios de cultura para Xanthomonas citri subsp. citri direcionados para estudos in vitro
Authors: Nocchi Paula Thaís Requena , Zanutto Carlos Alexandre , Guedes Terezinha Aparecida , Nunes William Mário de Carvalho
Published: August 2024

O cancro cítrico, causado pela bactéria Xanthomonas citri subsp. citri é uma das doenças mais importantes da citricultura. O estudo das condições de isolamento e manutenção de isolados de X. citri subsp. citri, o conhecimento de sua exigência nutricional e escolha de um meio de cultura eficiente para seu desenvolvimento é imprescindível para posteriores estudos in vitro, como no estudo de sua diversidade genética. Assim, o objetivo deste trabalho foi avaliar a eficiência de 8 diferentes meios de cultura na manutenção de isolado de X. citri subsp. citri proveniente de cultura pura (isolado Xcc 306) obtida junto ao acervo de culturas puras do Fundo de Defesa da Citricultura (Fundecitrus). Este isolado foi cultivado nos meios Nutriente Agar (NA), Manitol Glutamate Yeast (MGY), Kado (D5), 523, Luria Bertani (LB), Dextrose Yeast Glutamate (DYGS), Yeast Dextrose Carbonate (YDC) e Wilbrink (WB). Todos os isolados apresentaram diferença de crescimento nos meios de cultura estudados, entretanto, o meio D5 não se mostrou eficiente. O meio MGY foi o mais eficiente e com o menor custo dentre os meios de cultura estudados.
Complicações pulmonares em pacientes com doença falciforme
Authors: Carvalho Wagner de , Santos Oliveira Sabrina , Pereira Ribeiro Lucas Ian , Pereira Cassiano Dainára Carla , Paes Silva Mariana , Debortoli de Carvalho Luciana , Conceição da Guarda Caroline , Aleluia Milena Magalhães
Published: August 2024

A doença falciforme (DF) é uma desordem genética que através de uma mutação de ponto resulta na hemoglobina S (HbS) e culmina em uma série de manifestações clínicas, como fenômenos vaso-oclusivos e alterações pulmonares. Este artigo tem como objetivo realizar uma revisão bibliográfica narrativa acerca dos mecanismos fisiopatológicos e clínicos da DF, em relação às alterações pulmonares apresentadas pelos pacientes. As principais complicações cardiopulmonares são síndrome torácica aguda, pneumonia e hipertensão pulmonar, cuja etiologia pode também estar relacionada a uma série de infecções virais e bacterianas. Diversos mediadores inflamatórios encontram-se elevados na exacerbação da doença falciforme, em especial a substância P, que age como marcador dos episódios de vaso-oclusão. O tratamento com hidroxiureia reduz os níveis de HbS; e a fisioterapia respiratória evita perdas funcionais e mantém a oxigenação tecidual em níveis satisfatórios. Desta forma, é notório a importância de monitorizar os níveis de HbS em indivíduos com doença falciforme periodicamente.
NeoPain: aplicativo móvel para avaliação da dor em recém-nascidos internados
Authors: Silva Henrique Gleison , Andrade Adriana da Silva Barros , Bezerra Sandra Marina Gonçalves , Calçada Dario Brito
Published: August 2024

A dor é um fenômeno complexo, especialmente quando se trata de neonatos, exigindo uma avaliação cuidadosa e estratégias de tratamento eficazes. Este estudo metodológico descritivo de desenvolvimento experimental teve como foco a construção de um aplicativo móvel, denominado NeoPain, com abordagem quantitativa. O processo foi dividido em três etapas: revisão integrativa de literatura sobre escalas de avaliação e intervenções não farmacológicas para alívio da dor, validação de conteúdo por um comitê de especialistas e desenvolvimento do software. O aplicativo foi desenvolvido utilizando a ferramenta de prototipação Figma, com ênfase nos princípios de UI/UX para proporcionar a melhor experiência aos usuários. Na programação, optou-se pelo uso do Flutter, um framework da Google que utiliza a linguagem Dart para criar aplicativos móveis nativos.
Desafios docentes no ensino de Biologia: diagnóstico sobre o perfil de professores, conteúdos complexos e fatores limitantes da área
Authors: Costa Arnaldo Ferreira da , Souza Diego Nathan do Nascimento , Bezerra Nicholas Morais , Marques Regina Célia Pereira , Lima Leandro Alves de , Santos Pablo de Castro
Published: August 2024

Este trabalho teve como objetivos identificar o perfil dos professores de Biologia, os conteúdeos considerados mais complexos e os principais fatores limitadores para o ensino de Ciências Biológicas no ensino médio. A pesquisa diagnóstica foi desenvolvida através de questionário estruturado com 15 professores efetivos e temporários da disciplina de biologia, de 15 escolas que fazem parte da 14° Diretoria Regional de Educação e Cultura - DIREC, do Estado do Rio Grande do Norte. Em relação a formação acadêmica dos professores, constatou-se que cerca de 34% não são formados na área específica da disciplina, nenhum possui pós-graduação concluída e mais da metade (53,3%) possuem somente até 10 anos de docência. Já em relação aos conteúdos considerados mais complexos para lecionar, pôde-se observar que os mais citados foram: bioquímica com 31%, biofísica com 23% e genética com 19%, e além disso foram apontadas as principais causas das dificuldades, que foi o fato desses conteúdos possuírem um alto grau de abstração, grande quantidade de termos específicos e dificuldade de contextualização.
impact of the COVID-19 pandemic on nursing practices and patient care
Authors: Alanazi Dhiyaa Munawer , Alonaz Reem Saleh , Alanazi Mohammed Ali , Alqubaysi Hissah Abdulkarim , Alotaibi Bader Majed , Alshammari Abrar Fayadh , Alzuhair Noor Abdulaziz , Alenizi Amal Alhumidy , Alenezi Saleh Zuwayel , Alshammari Albandari Khudhayr , Al Enazi Sami Mohammed , Almanna Mohammad Abdullah , Alaboush Khalid Salem , Alanizi Fayez Khalaf
Published: August 2024

Background: The COVID-19 pandemic, which began in late 2019, rapidly escalated into a global crisis, profoundly affecting healthcare systems worldwide. Nurses, as frontline workers, faced significant challenges due to the overwhelming number of COVID-19 cases, strained resources, and heightened stress levels. Despite numerous publications addressing these issues, there is a need for a systematic review to synthesize credible findings and better understand the challenges faced by nurses. Aim: This review aims to examine the impact of the COVID-19 pandemic on nursing practices and patient care, focusing on the major challenges encountered by nurses during the pandemic and the implications for nursing practice. Methods: A narrative review was conducted based on a literature search that identified 22 relevant studies, including quantitative surveys, qualitative studies, and mixed-methods research. Thematic analysis was employed to identify and synthesize recurring themes from the studies, focusing on physical and mental exhaustion, PPE-related challenges, psychosomatic disturbances, and effective mitigating strategies. Results: Key themes identified include severe physical and mental exhaustion among nurses, challenges with PPE shortages and usability, widespread psychosomatic disturbances, and various factors that could alleviate these challenges. Nurses experienced significant stress, anxiety, and physical discomfort due to extended work hours and inadequate PPE.
Recent innovations in oral drug delivery systems: Examining current challenges and future opportunities for enhanced therapeutic efficacy
Authors: Almansour Mohammed Ahmed , Aldosary Mubarak Saad , Almegbel Maysam Taysir , Alsubaie Sultan Abdullah , Alzahrani Ahlam Mohammed
Published: August 2024

Introduction: Oral drug delivery remains a cornerstone of therapeutic administration due to its ease of use and broad patient acceptance. However, delivering drugs orally poses significant challenges due to the complex and hostile environment of the gastrointestinal tract (GIT), including anatomical, biochemical, and physiological barriers. Aim: This article aims to explore recent innovations in oral drug delivery systems, focusing on addressing current challenges and identifying future opportunities for enhancing therapeutic efficacy. Methods: The study reviews advancements in oral drug delivery systems, including novel nanomedicines, microfabricated devices, and targeted delivery technologies. It synthesizes research findings from recent literature to highlight the evolution of these technologies and their impact on drug delivery. Results: Recent innovations include nanoparticles, microemulsions, and microfabricated devices, which enhance drug stability, targeting, and bioavailability. Nanoparticles, such as liposomes and solid lipid nanoparticles, protect drugs from the GIT environment and improve their absorption. Microfabricated devices, such as microneedles and micropatches, offer controlled and targeted drug release. Additionally, advancements in smart drug delivery systems, such as pH-sensitive and enzyme-responsive systems, provide precise control over drug release. Conclusion: Advances in oral drug delivery systems have significantly improved the ability to overcome GIT barriers, enhancing the effectiveness of oral medications.
Effect of current density variation in the electrocoagulation process for the treatment of brewery wastewater
Authors: Sachett Felipe Henrique , Duarte Jocelei , Silvestre Wendel Paulo , Baldasso Camila
Published: August 2024

Breweries generate substantial amounts of wastewater, typically ranging from 3 L to 10 L per liter of beer produced. This wastewater possesses acidic characteristics and carries a high organic load, making it a suitable candidate for electrocoagulation (EC) treatment. EC treatment uses aluminum electrodes to generate an on-site coagulating agent, reducing the concentration of solids, organic load, and color in the wastewater. In this study, the present data were used to compare the efficiencies of different current densities (CD) applied to the EC process for treating raw brewery wastewater (RBW). The RBW underwent treatment with aluminum electrodes, with a CD of 12.00 A∙cm-2 and 13.23 A∙cm-2. The raw and treated samples were analyzed, and the data was analyzed statistically. Both CDs demonstrated effectiveness in reducing pollutant content. The process successfully reduced turbidity (99.9 %). Furthermore, the process effectively removed color across all wavelengths analyzed. The treatment process also showed promise in removing solid content, with a maximum removal efficiency of 84.5 % for suspended solids. Statistical analysis of the collected data indicates that treatment with a CD of 13.23 A∙cm-2 was more effective in treating brewery wastewater without significantly increasing the concentration of Al3+. The data presented in this study strongly supports the proposed treatment's efficacy in reducing pollutant concentrations in brewery wastewater.
Galectin-3, Matrix Metalloproteinase-3 and TLR-2 Receptor as Novel Biomarkers in the Diagnosis of Rheumatoid Arthritis
Authors: Hameed Muna Rashid , Khaleel Fayhaa Muqdad , Gorial Faiq Isho
Published: August 2024

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that activates arthritogenic immune responses, along with many of the systemic inflammatory cascades that result in synovitis and the progressive irreversible destruction of affected joints. Studies have demonstrated the pathogenic role of some biomolecules and autoantibodies in RA disease. Some other markers, like erythrocyte sedimentation rate (ESR), acute phase reactant protein (CRP), and rheumatoid factor (RF), have also been used successfully to diagnose and treat RA. These are the anticyclic citrullinated peptide (ACPA) autoantibody, tumor necrosis factor-alpha (TNFα), and interleukin 1 and 6 (IL-1, IL-6). Many others are still under study. In this review, we focused on a few biomolecules that could either directly or indirectly contribute to the pathogenesis of RA, aiming to demonstrate their diagnostic characteristics and capacity to forecast the disease. These are Galectin-3 (Gal-3), matrix metalloproteinase-3 (MMP-3) and toll-like receptor 2 (TLR-2). After reviewing peer-reviewed studies from 24 years ago, we concluded that these markers could potentially serve as prognostic factors for RA disease activity in the future and have reasonable diagnostic power. We believe that combining these markers with traditional ones could enhance the accuracy and clarity of clinical diagnosis, as well as track the effectiveness of current therapies.
Anti-IL-4Rα monoclonal antibody (CM310) in patients with chronic rhinosinusitis with nasal polyps (CROWNS-2): Rationale and design of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Authors: Shen Shen , Yan Bing , Wang Ming , Wu Di , Wang Chengshuo , Zhang Luo
Published: August 2024

Background:

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease that affects a large proportion of the global population. The treatment of CRSwNP, especially eosinophilic CRSwNP (ECRSwNP), has always been of great obstacle. Our previous phase 2 trial showed that CM310, a monoclonal antibody that targets interleukin-4 receptor alpha, was both safe and effective in reducing the size of nasal polyps, improving symptom scores, and increasing the quality of life for those with severe ECRSwNP.

Objective:

This phase 3 trial aims to evaluate the efficacy, safety, pharmacokinetic, pharmacodynamic, and immunogenicity of CM310 in participants with CRSwNP.

Result:

The CROWNS-2 is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 trial. The study consisted of a screening/run-in period (up to 4 weeks), a treatment period (24-week double-blind treatment period plus 28-week maintenance period), and a safety follow-up period (8 weeks). The study planned to enroll 180 participants with CRSwNP (at least 60% of ECRSwNP) to receive CM310 300 mg/placebo every 2 weeks (Q2W) subcutaneously for a total of 12 doses in double-blind treatment period and 300 mg CM310 Q2W subcutaneously for a total of 14 doses in maintenance period. Enrolled participants continued to use mometasone furoate nasal spray throughout the study. The primary endpoints are a change from baseline in nasal polyp score and nasal congestion score at week 24 between CM310 and placebo in both ECRSwNP and CRSwNP.

Conclusion:

The CROWNS-2 is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical study to evaluate the efficacy and safety of CM310 in patients with CRSwNP.

Trial registration:

NCT05436275.
Genetic variability in Jatropha curcas and prediction of oil contents on the basis of seed traits
Authors: Pant K. , Gupta Tara , Gupta R. , Kumar Dinesh
Published: August 2024

The study on Jatropha curcas was conducted in Himachal Pradesh to estimate the genetic variability for the plant morphological characters, seed traits and nursery growth parameters among the different seed sources. The characters number of fruits/tree, number of seeds/tree and oil content on seed basis had high genotypic coefficient of variation, heritability and genetic advance; indicating importance of these characters for selection tools. Results also revealed that Seed viability and germination energy has no significance for selection because of low genetic estimates. Nineteen characters of Jatropha curcas were classified in to four factors contributing to 89.79 % of total variation. Oil contents and seed germination can be best estimated by using quadratic model on the basis of different seed traits.
Animal’s Gaze in Sinha’s Animal’s People
Authors: Mansur Visam , Mansour Ashraf Waleed
Published: August 2024

The article critically studies Indra Sinha's Animal’s People by critiquing Animal, a deformed young man born in the aftermath of the Bhopal disaster. Narrated by Animal himself via tapes transcribed by an Australian journalist, the novel explores themes of animality, identity, and representation. The article draws on a variety of scholarly perspectives, including ecocriticism, postcolonial criticism, posthumanism, and others to uncover the complexities of Animal's character. Drawing on the insights of Julietta Singh, Justin Omar Johnston and Andrew Mahlstedt, among many other scholars, the paper critiques common interpretations of Animal as the voice of the oppressed and offers a new perspective on his character. The paper argues that Animal's voyeuristic gaze is not compatible with typical animal behavior, but rather affirms Animal’s compromised morality as a deformed human being. Despite his efforts to establish his animality, Animal's actions betray macho human tendencies and challenge the idea that he is the appropriate figure to represent animals and ecology at large.
Exploring the Role of English Literature in Developing Cultural Competence among ESL Students
Authors: Julia Pedaveti , Jeyanthi B
Published: August 2024

The study of English literature is a fascinating and effective technique for teaching English. It combines language instruction with literary analysis, contextualizing language, raising cultural awareness, honing critical thinking skills, expanding vocabulary and knowledge, boosting interpersonal skills, and enhancing writing ability. Teachers can enhance students' learning experience in English as a second language by employing these strategies: selecting appropriate texts, integrating reading practices, designing literacy exercises, assessing aesthetic aspects, and creating writing projects. The use of English literature in language studies fosters students' language development in relevant and real-world contexts, leading to a greater understanding of the language and its cultural nuances. Furthermore, culture affects values, beliefs, rituals, and behaviors and is reflected in language, dress, food, materials, and social institutions of a group (“Purnell, 2002”) qtd in (Sharifi et al., 2019). This understanding underscores the importance of integrating cultural elements into language instruction to provide students with a holistic view of language and its sociocultural context. Additionally, this approach allows us to examine how literature and language resources portray people of various origins, identities, demographics, and competences, seamlessly integrating diverse perspectives into the educational framework. This research involves investigating how a more varied educational environment affects student motivation, self-esteem, and the ability to communicate across cultures.
Emotional Consequences of Gender-Based Violence: Influences on Ratnamala’s Decision-Making in The Story of Felanee
Authors: Boruah Bhagirath , Bari Rachel
Published: August 2024

This study analyses how the emotional consequences of gender-based violence (GBV) shape Ratnamala's decision to elope with Kinaram in Arupa Patangia Kalita's novel, The Story of Felanee (2011). Focusing on the sociocultural practices of 1940s Assam, this research reveals how GBV, particularly the oppressive norms of widowhood prevalent in Ratnamala's patriarchal, upper-caste Hindu community, profoundly impacts her emotional landscape and ultimately fuels her act of resistance through elopement. By integrating the decision-making framework of Ernst and Paulus with Damasio's Somatic Marker Hypothesis and Kahneman and Tversky's Prospect Theory, this paper provides a nuanced understanding of the interplay between GBV, emotional responses, and Ratnamala's pursuit of autonomy and happiness.
Understanding Saudi EFL Learners’ Perspectives on the Efficacy of the Flipped Learning Model: Problems and Prospects
Authors: Jamshed Mohammad , Albedah Fatimah , Allehyani Badr , Warda Wahaj Unnisa
Published: August 2024

The study assesses Saudi EFL learners’ perspectives on the efficacy of the flipped learning model, problems and challenges, and opportunities and prospects in Saudi Arabia. 261 respondents from different levels of the undergraduate program at the College of Science and College of Business Administration, Prince Sattam bin Abdulaziz University, Al-Kharj, KSA, were selected using a random sampling method. A questionnaire, with the adoption of modified items from some previous studies, was designed to collect the data. As the research looks at how specific independent variables (gender, year of study, and parents’ professional profile) shape the dependent variable (perspective/perceptions), the data was evaluated quantitatively (utilizing descriptive statistics). The findings revealed that Saudi EFL learners considered flipped classrooms an excellent alternative mode of instruction. In addition, it was observed that this approach to learning encountered certain challenges, such as lack of motivation, learners' incapacity to maintain self-discipline, and unmonitored instruction. It was also revealed that flipped classrooms in Saudi Arabia had considerable prospects due to its young tech-savvy population and its well-advanced infrastructure for learning. One-way ANOVA analysis found no significant statistical difference among the respondents based on their demographic profile. The study implies that issues related to motivation, self-regulated learning, and the learners' failure to stay disciplined in flipped classrooms must be addressed to make it an effective alternative mode of instruction.
Ludicidade, Experiência Estética, Videogames
Authors: Ferreira Emmanoel
Published: August 2024

A partir de diálogo com autores da filosofia pragmatista, dos game studies e da comunicação, este artigo tenciona compreender a relação entre experiência estética e mídias lúdicas, em particular os videogames, no que esta relação se distingue das experiências estéticas proporcionadas por mídias diversas, como a literatura, a música, o cinema e as artes em geral. Para melhor compreender esta relação, propõe-se a apresentação e o desenvolvimento de três eixos (ou chaves) epistemológicas, quais sejam: i) estética e agência; ii) estética e apropriação; iii) estética e política. Ademais, o presente artigo tenciona apresentar e comentar obras selecionadas de videogames, a fim de ilustrar a relação entre experiência estética e ludicidade em cada um daqueles respectivos eixos.
Sociologia dos jogos eletrônicos
Authors: Da Costa Everton Garcia
Published: August 2024

A indústria de jogos eletrônicos apresentou um crescimento massivo nas últimas duas décadas. Estima-se que, atualmente, cerca de 40% da população mundial jogue com frequência em ao menos um tipo de dispositivo – entre os mais jovens, esse percentual mais que dobra. As receitas movimentadas globalmente pelos jogadores de videogames são maiores do que as geradas pelos mercados do cinema e da música somados. Esses dados revelam que os videogames estão no centro da indústria do entretenimento. Todavia, embora sejam mídias em franca ascensão, as quais conectam bilhões de pessoas em todo o mundo e principal referência cultural para a juventude contemporânea, os jogos eletrônicos ainda não receberam a devida atenção por parte dos sociólogos. O objetivo deste artigo, justamente, consiste em investigar os motivos por trás do pouco interesse da sociologia pelo universo dos videogames. Mais que isso, defende-se o argumento de que, considerando os diversos aspectos sociais, simbólicos, ideológicos, as relações de poder, enfim, que permeiam os games, torna-se fundamental o desenvolvimento de um subcampo do pensamento sociológico dedicado à investigação dos jogos eletrônicos.
A gestão da (in)segurança ante a (des)estruturação do laço social em O som ao redor
Authors: Haiden de Lacerda Gustavo
Published: August 2024

Por meio do referencial teórico da Análise de Discurso materialista, em articulação com a Psicanálise freudo-lacaniana, este artigo analisa a gestão da (in)segurança por meio das (não) relações com a alteridade no filme O som ao redor. Tendo em vista as formas de materialização discursiva da (in)segurança no material fílmico, considerando uma estrutura social em constante (des)enlace, o movimento analítico enfoca a inserção de personagens crianças em meio às violências cotidianas do circuito familiar e social em que estão inscritas. O percurso de análise delineia cenas-limites catalizadoras de conflitos que culminam na relação violenta com o (O)outro, o qual se marca como uma presença ameaçadora que, ao perturbar a trama aparentemente estável da estrutura social, aponta para a insegurança não apenas direcionada para fora, mas que constitui de dentro.
Elevated Titanium Levels After Revision Total Hip Caused by Previously Unreported Mechanism
Authors: Josephson Brian G. , Damron Timothy A.
Published: August 2024

Introduction:

Metallosis from total hip arthroplasty is usually due to trunnionosis and is associated with elevated serum cobalt and chromium levels. Titanium levels usually remain normal.

Methods:

Here, we report two rare cases of elevated titanium levels, both with the same mechanism, which is a previously unreported cause of titanium metallosis.

Results:

In these cases, contact between cables and the titanium stem were the source.

Discussion:

Reports of isolated high titanium levels associated with total hip arthroplasty are rare. These cases illustrate a new mechanism from which this situation may arise.
Workers particularly sensitive to cardiovascular risk
Authors: Carlos Álvarez-Fernández , Manuel Vaquero-Abellán , Manuel Romero-Saldaña , Carlos Álvarez-López
Published: August 2024

Background: Of the 607 fatal occupational accidents that occurred in Spain in 2016, 37.9% were due to ischemic heart disease and stroke. Working conditions such as night work, noise or respiratory contaminants were associated with a higher cardiovascular incidence. The aim of the present study was to assess whether health surveillance in workers exposed to these conditions should include assessment of cardiovascular risk. Subjects and methods: A cross-sectional study was conducted in 680 workers in a public administration. The qualification of working conditions was obtained from the company risk assessment and from personal, anthropometric and analytical data, which allowed the assessment of cardiovascular risk in the medical examination performed in 2015. Results: 30.1% of the sample were exposed to these working conditions, with significant differences by sex (37% in men, 11.9% in women, p<0.05). According to REGICOR, 13.2% of those exposed were classified as particularly sensitive to cardiovascular risk. Conclusions: A large percentage of workers are exposed to TC related to a greater prevalence of cardiovascular pathology. The percentage of workers classified as especially sensitive to cardiovascular risk among those exposed suggests that this risk should be assessed in occupational health surveillance when there are working conditions related to cardiovascular pathology.
The Impact of Linguistic Diversity on Intercultural Communication in Nigerian Organizations: A Review
Authors: Kori-Siakpere Ufuoma , Gokeme Oghenetega , Omale Rosemary Ojona , Aniah Aloye Racheal , Ojukwu Prince Majizu , Okache Matthew Okache
Published: August 2024

Nigeria stands out globally for its profound cultural and linguistic diversity, encompassing over 500 distinct languages. Among these, the Hausa, Yoruba, and Igbo languages serve as predominant, with several hundred others classified as minority languages. This diversity not only reflects the country’s ethnic richness but also presents unique challenges and opportunities in organizational settings. However, this study examines deeply into the challenges and opportunities presented by Nigeria’s linguistic diversity within organizational contexts. It explores how language barriers impact daily interactions, teamwork, and overall organizational effectiveness. Drawing from a thorough review of scholarly literature sourced from reputable databases like Scopus, Web of Science, Google Scholar, Semantic Scholar, and ResearchGate, the study identifies prevalent issues and examines potential solutions. By addressing these complexities, the study aims to offer a comprehensive framework for understanding the elaborate dynamics of intercultural communication shaped by linguistic diversity in Nigeria. It emphasizes the critical need for proactive strategies that embrace diversity as a driver of innovation, collaboration, and sustainable organizational growth in today’s interconnected global business landscape. The findings underline the importance of fostering inclusive communication practices, promoting cultural sensitivity, and enhancing language proficiency among employees to effectively navigate and leverage Nigeria’s diverse cultural milieu for organizational success.
WAYS TO REDUCE COMMON IMPERFECTIONS IN
3D PRINTING
Authors:   “Gheorghe Asachi” Technical University of Iasi, Department of Machine Manufacturing Technology,
Blvd. Mangeron, No. 59A, 700050, Iasi, Romania, Mazurchevici Simona-Nicoleta , Catana Maria ,   “Gheorghe Asachi” Technical University of Iasi, Department of Machine Manufacturing Technology,
Blvd. Mangeron, No. 59A, 700050, Iasi, Romania
Published: August 2024

3D printing, or additive manufacturing, has greatly transformed multiple industries by allowing the creation of intricate designs and forms. Nevertheless, despite these advancements, the technology still confronts notable obstacles such as expensive costs, slow printing speeds, restricted part sizes, limited strength and why not imperfections that appear due to equipment, parameter settings or other various reasons. Fused deposition modelling (FDM) is a rapidly expanding technique in the field of additive manufacturing, namely in printing. The performance of the printed parts produced as a result is constrained in comparison to those achieved through alternative manufacturing methods, mostly due to the inherent shortcomings. Therefore, there has been an increased focus on developing strategies to address these limitations in recent years. The primary objective of this study is to identify and examine the primary weaknesses that may arise, as well as to explore the existing techniques for mitigating or reducing them, with the aim of improving the functional characteristics of the printed components.
FIBROTERAPIA COM MODULADORES DE CFTR PARA PACIENTES COM FIBROSE CÍSTICA- ARTIGO DE REVISÃO
Authors: Silva Daniela Diniz Martins da , Chaimowicz Beatriz de Faria , Santos Clara Chagas Barbosa , Pimenta Clara Rubião , Sternick Letícia Ribeiro
Published: August 2024

INTRODUÇÃO: A fibrose cística é uma doença genética na qual ocorre uma mutação no gene codificador da proteína CFTR que regula o transporte de cloro na membrana. Com isso, há prejuízo na reabsorção de algumas substâncias, o que acaba prejudicando diversos órgãos. Ainda não há uma cura descoberta mas, recentemente, estão sendo estudados medicamentos moduladores de CFTR, que, quando combinados e aplicados em pacientes homozigotos para o gene F508del, formam uma terapia eficaz para a doença. OBJETIVO: Discorrer sobre a pesquisa acerca da terapia medicamentosa usada no tratamento da doença fibrose cística. MÉTODO: Revisão literária integrativa de artigos dos bancos de dados SciELO, PubMed, NCBI, The New England Journal of Medicine, UpToDate, utilizando como descritores os termos em português e inglês ‘’Cystic Fibrosis’’, ‘’Tezacaftor’’, ‘’Ivacaftor’’ e ‘’CFTR  Modulators’’ em artigos publicados entre 2017 e 2019. RESULTADO: Houve melhora do quadro respiratório com aumento do volume expirado forçado nas duas terapias, sendo que as combinadas ou triplas, (VX-tezacaftor-ivacaftor) se mostraram a mais eficazes. CONCLUSÃO: Com essa revisão, foi possível compreender a relação de eficácia dos remédios ivacaftor e tezacaftor (associados ou não com VX-659 e o VX-445) e observar os efeitos positivos dessa terapia para um melhor prognóstico da fibrose cística, podendo dar esperança de melhora na qualidade de vida de pacientes com essa doença.
GÖÇ VE EKOLOJİK AYAK İZİ ARASINDAKİ İLİŞKİ: BOOTSTRAP ARDL YAKLAŞIMI
Authors: Kapçak Servet
Published: August 2024

Göç eski dönemlerden beri sosyal çevre üzerinde önemli etkilere sahiptir. Özellikle siyasi karışıklıklar ve iklimsel olaylar göçü tetiklemektedir. Küreselleşmeyle birlikte hızlı nüfus artışı çevresel bozulmaları artırmaktadır. Siyasi, sosyal ve politik nedenler ile göç eden insanlar, gittikleri yerlerde çevresel bozulmayı artırabilmektedir. Bu çalışmada temel amaç; göç ile ekolojik arasındaki ilişkiyi Türkiye açısından araştırmaktır. Çalışmada bağımlı değişken ekolojik ayak izi, ana bağımsız değişken göç kavramı ve açıklayıcı değişken ise yenilenebilir enerji tüketimi kullanılmıştır. 1990-2021 dönemi için Bootstrap ARDL yaklaşımı tercih edilmiştir. Değişkenlerin katsayıları arasındaki ilişkiyi değerlendirebilmek için FMOLS tahmincisine başvurulmuştur. Bootstrap ARDL sonuçlarına göre uzun dönemde değişkenler arasında eşbütünleşme olduğu tespit edilmiştir. FMOLS tahmincisi sonuçlarına göre göç sayısında meydana gelebilecek %1’lik bir artış ekolojik ayak izini 0.733142 oranında artırmaktadır. Yenilenebilir enerji tüketiminde meydana gelen %1’lik artış ekolojik ayak izini -8.526182 oranında azaltmaktadır. Bulgular değerlendirilirse göç olgusu çevresel bozulmayı artırırken, yenilenebilir enerji tüketimi çevresel bozulmayı azaltmaktadır.
Distributed Acoustic Sensing Signal Model Under Static Fiber Conditions
Authors: SAM A.ROBERT , PUNITHAVATHY G , AYYAPPAN G.S
Published: August 2024

This paper presents a statistical model for distributed acoustic sensor interrogation units that utilizes laser pulses transmitted into fiber optics. Interactions within the fiber lead to localized acoustic energy, resulting in backscatter, which is a reflection of the light. Explicit equations were used to calculate the amplitudes and phases of backscattered signals. The proposed model accurately predicts the amplitude signal spectrum and autocorrelation, aligning well with experimental observations. This study also explores the phase signal characteristics relevant to optical time-domain reflectometry (OTDR) system sensing applications, demonstrating consistency with the experimental results. The experiments were conducted using Python coding, enabling the analysis of the individual components of the Distributed Acoustic Sensing (DAS) system. The assumptions of the model include the static condition of the fiber, implying the absence of external forces or vibrations. Consequently, no external acoustic disturbances were considered. The backscattered signal comprises a random noise component resulting from intrinsic fiber imperfections, and a coherent component arising from the interplay between the laser pulse and the fiber. Keywords: distributed acoustic sensing, fiber optics, optical time-domain reflectometry, Rayleigh scattering.
Challenges in Accounting for Carbon: Analysis of Accounting Policies of the World's Largest Polluters
Authors: Gomes Sonia M. S. , Ribeiro Maisa S. , Freire Fátima S. , Sardeiro Luciana S. M. , Guessi Alana B.
Published: August 2024

The study's focus was on examining the accounting policies related to carbon credits of the top 100 global GHG emitters, as mentioned by Kouloukoui et al. (2019). Of these 100, only 36 gave access to the CDP questionnaire. We used the model proposed by Lovell et al. (2010) to examine carbon credit accounting choices, employing content analysis with NVivo software and statistical analysis with Stata. The financial statements (FS) and explanatory notes of 247 companies from different countries and sectors, such as oil and gas, mining, coal, transport and marine logistics, and the chemical sector, were analyzed from 2015 to 2021. Finally, nine companies provided information on the accounting treatment for carbon credits. The results indicate a predominance of classification as inventories, followed by intangible assets, measurement at cost, and liabilities accounted for by the excess carbon credits owed about existing assets at market value. We observed significant heterogeneity in accounting policies, which remained over time. The lack of standardization and consistency in reporting methods and the concealment of accounting records in this context make it challenging to compare practices, compromising the evaluation of companies' performance, the decision-making of investors and other agents, and the transparency and accountability of this market. These findings highlight the need for a more coherent and rigorous approach to accounting for carbon credits, especially considering the urgent challenges of climate change.
Reviewer Acknowledgements for Journal of Education and Learning, Vol. 13, No. 4
Authors: Lin Grace
Published: August 2024

Reviewer Acknowledgements for Journal of Education and Learning, Vol. 13, No. 4, 2024