bluuebunny/crossref_metadata_2025 huggingface dataset:
A felelős vállalat szindróma
Authors: Angyal Ádám
Published: April 2021

A cikk a felelős vállalati magatartás gondolatának elterjesztéséhez kíván hozzájárulni. Ennek érdekében a szerző bemutatja a társadalmi felelősség értelmezési kereteit, dimenzióit. Összegyűjtötte a felelős viselkedésre vonatkozó értékelési, mérési rendszereket és mindazokat a nemzetközi dokumentumokat, amelyek meghatározzák a társadalmi felelősség kereteit. Végezetül több változatban is bemutatja, hogy mit is szoktak felelős magatartás alatt érteni, milyen viselkedés jellemző a társadalmilag felelős vállalkozásokra. Anélkül, hogy a különféle vállalati felelősség meghatározások részleteibe mélyedne, megfogalmazza, hogy mit ért e fogalom alatt. Az üzleti gyakorlatban a felelős vállalati magatartás a társadalmi célok eléréséhez való hatékony hozzájárulás.
A vezetői számvitel alkalmazásának szükségessége a mezőgazdaságban
Authors: Zárda Nóra
Published: April 2021

Napjainkban a mezőgazdasági vállalkozások vezetésében már elengedhetetlen a controlling és az ahhoz szorosan kapcsolódó vezetői számvitel alkalmazása. A hosszú távú eredményes működéshez és a versenyképességhez nélkülözhetetlen a jövőorientált vezetői gondolkodás és a jól előkészített, gyors döntések meghozatalának képessége. A vezetői számvitel nélkülözhetetlen szerepet játszik a vállalatok sikereiben, alkalmazása egyértelműen növeli a jövedelmezőséget (Kittredge, 2004). Alkalmazása ezenkívül hozzásegíti a vállalkozásokat egyéb alapvető céljaik – mint például a megfelelő készletezés, hatékony erőforrás-felhasználás, fizetőképesség fenntartása, nyereséges gazdálkodás – eléréséhez is (Sabján – Sutus, 2003). A mezőgazdaság, a biológiai és természeti tényezőknek köszönhetően, egy speciálisan kockázatos nemzetgazdasági ág, amely jelentős kezdeti tőkeberuházást igényel, ezért itt különös szükség van a megfelelő pénzügyi és stratégiai tervezésre és a vállalkozás jövőbeni helyzetének megbízhatóbb ismeretére.
Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis
Authors: Kanmura Shuji , Morinaga Yuko , Tanaka Akihito , Komaki Yuga , Iwaya Hiromichi , Kumagai Kotaro , Mawatari Seiichi , Sasaki Fumisato , Tanoue Shiroh , Hashimoto Shinichi , Sameshima Yoichi , Ono Yohei , Ohi Hidehisa , Ido Akio
Published: April 2021

INTRODUCTION:

DEFA1A3 encodes human neutrophil peptides (HNPs) 1–3 and has multiple copy number variations (CNVs). HNPs are associated with innate immunity. Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disorder, is a life-threatening condition, and predictive markers of UC severity are needed. This study investigated the relationship between DEFA1A3 CNV and UC severity.

METHODS:

This study enrolled 165 patients with UC. The relationship between DEFA1A3 CNV and disease severity was analyzed based on Mayo score, patient characteristics, and treatment methods. In addition, serum and stimulated neutrophil-derived HNP concentrations were also measured in patients with high and low DEFA1A3 CNV.

RESULTS:

DEFA1A3 CNV was significantly correlated with Mayo score and white blood cell count (R = 0.46, P < 0.0001; R = 0.29, P = 0.003, respectively), and only high copy numbers of DEFA1A3 were independent factors for severe UC (P < 0.001, odds ratio: 1.88, 95% confidence interval, 1.34–2.61). The number of severe UC patients with high DEFA1A3 CNV was significantly greater than those with low CNV. We confirmed the associations between DEFA1A3 and UC severity using a validation cohort. In addition, the HNP concentration in high-copy number patients was significantly higher after neutrophil stimulation than that in low-copy number patients.

DISCUSSION:

This study demonstrated that there is a correlation between DEFA1A3 copy number and severity in patients with UC. In addition, neutrophils from UC patients with higher DEFA1A3 CNV had high reactivity of secretion of HNPs after stimulation. DEFA1A3 CNV may be a novel severity marker and a potential therapeutic target for UC.
Identification of High-Risk Patients With Nonalcoholic Fatty Liver Disease Using Noninvasive Tests From Primary Care and Endocrinology Real-World Practices
Authors: Younossi Zobair M. , Pham Huong , Felix Sean , Stepanova Maria , Jeffers Thomas , Younossi Elena , Allawi Hussain , Lam Brian , Cable Rebecca , Afendy Mariam , Younoszai Zahra , Afendy Arian , Rafiq Nila , Alzubaidi Nahrain , Ousman Yasser , Bailey Marc , Chris Zik , Castillo-Catoni Maria , Fozdar Pratima , Ramirez Maria , Husain Mehreen , Hudson Evis , Schneider Ingrid , Golabi Pegah , Nader Fatema
Published: April 2021

INTRODUCTION:

We aimed to identify high-risk nonalcoholic fatty liver disease (NAFLD) patients seen at the primary care and endocrinology practices and link them to gastrohepatology care.

METHODS:

Using the electronic health record, patients who either had the diagnosis of type 2 diabetes or had 2 of 3 other metabolic risk factors met criteria for inclusion in the study. Using noninvasive fibrosis tests (NITs) to identify high risk of fibrosis, patients who met the NIT prespecified criteria were referred to gastrohepatology for clinical assessment and transient elastography.

RESULTS:

From 7,555 patients initially screened, 1707 (22.6%) met the inclusion criteria, 716 (42%) agreed to enroll, and 184 (25.7%) met the prespecified NIT criteria and eligibility for linkage to GE-HEP where 103 patients (68 ± 9 years of age, 50% men, 56% white) agreed to undergo linkage assessments. Their NIT scores were APRI of 0.38 ± 0.24, FIB-4 of 1.98 ± 0.87, and NAFLD Fibrosis Score of 0.36 ± 1.03; 68 (66%) linked patients had controlled attenuation parameter >248 dB/m, 62 (60%) had liver stiffness <6 kPa, and 8 (8%) had liver stiffness >12 kPa. Liver stiffness for the overall group was 6.7 ± 4.2 kPa, controlled attenuation parameter 282 ± 64 dB/m, and FAST score 0.22 ± 0.22. Linked patients with presumed advanced fibrosis had significantly higher body mass index (36.4 ± 6.6 vs 31.2 ± 6.4 kg/m2, P = 0.025) and higher NIT scores (APRI 0.89 ± 0.52 vs 0.33 ± 0.14, FIB-4 3.21 ± 2.06 vs 1.88 ± 0.60, and NAFLD Fibrosis Score 1.58 ± 1.33 vs 0.25 ± 0.94).

DISCUSSION:

By applying a simple prespecified multistep algorithm using electronic health record with clinical risk factors and NITs followed by transient elastography, patients with nonalcoholic fatty liver disease seen in PCP and ENDO practices can be easily identified.
Consumers' Attitude Towards Eco Friendly Textile Products
Authors: Matičič Zver Manca , Vukasović Tina
Published: April 2021

Care for the environment is directly connected to consumer behaviour. The authors summarize in their research the findings of different authors who have examined various aspects of socially responsible consumption, green consumption and ethical consumer behaviour. Their results have shown that consumers contribute to active environmental problem solving by selecting and purchasing environment-friendly textile products. Today’s consumers have started to act more ethically and responsibly when purchasing and considering the products they need. The goal of this paper is to explore Slovenian consumers' perception of eco-friendly textile products, to investigate underlying attitudes and perceptions, and consumers’ willingness to buy eco-friendly textile products in the future. Research questions focus on knowledge about eco-friendly textile products, attitudes, perception and purchasing behaviour as it relates to eco-friendly textile products. Slovenian consumers express a positive attitude towards eco-friendly textile products. They perceive eco-friendly textile products as products with a certificate, as produced in an eco-friendly manner, as products with a higher price than conventional products and as sustainable products. The most important factor when purchasing eco-friendly textile products is the label ''product with certificate'' or ''certified product'', as consumers buy eco-friendly textile products labelled as such. Respondents intend to purchase eco-friendly textile products in the future. The results of this research could be used in planning the further development of the eco-friendly textile products market. Overall positive attitudes toward eco-friendly textile products should be reinforced, while consumers can be influenced through targeted advertising. The results of this research can be used to plan further marketing activities.
Influence of Needle-punching Parameters for the Preparation of Polypyrrole-coated Non-woven Composites for Heat Generation
Authors: Maity Subhankar , Pandey Shivangi , Kumar Alok
Published: April 2021

This work deals with the preparation and characterization of electrically conductive needle-punched non-woven composites for heat generation. Electro-conductive non-woven composites were prepared through the in situ chemical polymerization of pyrrole with FeCl3 (oxidant) and p-toluene sulfonic acid (dopant). A two-stage double-bath process was adopted for the in situ chemical polymerization of pyrrole. The effect of parameters such as fibre fineness, needle-punching density and depth of needle punching on a polypyrrole add-on, and surface resistivity were studied by employing the Box-Behnken response surface design. It was observed that fibre fineness was the most influential parameter of the polypyrrole add-on. The lowest surface resistivity of the polypyrrole coated sample (200 g/m2, prepared with a punch density of 200 punch/cm2, a punching depth of 6 mm and fibre fineness of 2.78 dtex) was found to be 9.32 kΩ/□ with a polypyrrole add-on of 47.93%. This non-woven composite demonstrated good electrical conductivity and exhibited Joule’s effect of heat generation. Due to the application of a 30 V DC power supply, the surface temperature of the non-woven composite rose to 55 ºC from a room temperature of 37 ºC. Optical and electron microscopy images of the non-woven composites showed that PPy molecules formed a uniform coating on the non-woven surface. FTIR studies evidenced the coating of PPy on a polyester surface. These coated non-woven composites were highly electrically conductive and practically useful for the fabrication of heating pads for therapeutic use.
A multimodal approach to intraoperative neuromonitoring of the spinal cord during spinal deformity correction
Authors: Buzunov A. V. , Vasyura A. S. , Dolotin D. N. , Sergunin A. Yu. , Novikov V. V.
Published: April 2021

Objective. To analyze the results of a multimodal approach in intraoperative neurophysiological monitoring during surgical correction of spinal deformities.

Material and Methods. The paper describes a variant of intraoperative neurophysiological monitoring of the spinal cord and nerve root functions which was used in the correction of scoliotic deformity of the spine in 138 patients. Surgery was performed in 83 patients aged 10 to 17 years and in 55 patients older than 17 years. The average age of patients was 20.23 ± 8.3 years. There were 41 male and 97 female patients. The primary scoliotic curve was localized in the thoracic spine in 90 cases, in the thoracolumbar spine in 27 cases, and in the lumbar spine in 21 cases.

Results. In the early postoperative period, two patients developed neurological deficit, the electrophysiological predictors of which were recorded during intraoperative neurophysiological monitoring. In one case, the deficit gradually regressed completely due to the measures taken by the operating team during surgery; in the second case, a persistent neurological deficit in the form of lower paraplegia persisted, despite the measures taken during the surgical treatment. In other cases, intraoperative neurophysiological monitoring did not reveal any changes in the spinal cord and nerve roots, which in the early postoperative period would lead to the appearance or aggravation of motor deficit.

Conclusion. A multimodal approach to intraoperative neurophysiological monitoring provides an operating surgeon with an objective assessment of the state of the spinal cord and nerve roots at any stage of surgery, which allows timely identification and elimination of the causes of their damage, thereby reducing the likelihood of neurological deficit development or aggravation in the postoperative period.
Cervical intervertebral disc denervation during rotator cuff tendon plasty
Authors: Peleganchuk A. V. , Leonova O. N. , Alekperov A. A.
Published: April 2021

Objective. To analyze the effect of denervation of intervertebral discs in the cervical spine on the results of surgical treatment of patients with injuries to rotator cuff tendons of the shoulder joint.

Material and Methods. Study design: descriptive hypothesis-generating study. The study included patients requiring surgical treatment of rotator cuff tear.  Two groups were identified: Group A included 28 patients who underwent plastic repair of rotator cuff tear with additional denervation of intervertebral discs, and Group B – 30 patients who underwent only plastic surgery for rotator cuff tear. The intensity of pain according to the VAS, functional activity due to neck pain (NDI), functionality of the shoulder joint (UCLA), and the degree of intervertebral disc degeneration according to MRI were assessed, and the effectiveness of treatment was determined. Statistical calculations were performed using the RStudio program.

Results. In the group of patients with denervation of intervertebral discs, a more pronounced decrease in the intensity of pain syndrome at 3, 6, and 12 months (p < 0.001; p < 0.001; and p = 0.002), a more proportion of effectively treated patients at 3 months (p = 0.003), and significant increase in functional activity according to NDI at 3, 6 and 12 months of follow-up period (p < 0.001; p = 0.010; and p = 0.045) were observed.

Conclusions. There is an underestimation of the role of degenerative cervical spine pathology in the occurrence of shoulder joint pain. In the case of rotation cuff plasty the additional denervation reduces the intensity of pain syndrome in the shoulder joint in the postoperative period.
Posterior approach to ventrally and dorsally located spinal meningiomas
Authors: Grygoriev G. B. , Cherebillo V. Yu. , Goranchuk D. V.
Published: April 2021

Objective. To analyze the outcomes of posterior approach in the surgery of intradural extramedullary meningiomas located ventrally and dorsally in relation to the spinal cord denticulate ligaments.

Material and Methods. The study included 29 patients with spinal intradural meningiomas operated on using posterior approach. Patients were divided depending on the tumor location relative to the denticulate ligaments into ventral (n = 13) and dorsal (n = 16) groups. The surgery duration, the degree of tumor resection, clinical outcomes, the presence and nature of complications, and the frequency of recurrence were assessed.

Results. The average follow-up period was 29 (6 to 61) months. Total tumor removal was performed in 93.1 % of cases: 11 cases (84.6 %) in ventral group and 16 cases (100.0 %) in dorsal group. The average duration of surgery was 136 minutes for dorsal meningiomas and 181 minutes for ventral meningiomas (p < 0.05). Complications in the form of CSF leakage were registered in two patients (6.9 %). In 11 (84.6 %) patients with ventral meningiomas and 15 (93.7 %) patients with dorsal meningiomas, an improvement or preservation of neurological functions at the pre-surgery level was observed. Recurrences were observed in two patients (6.9 %).

Conclusion. Patients with spinal meningiomas have a favorable neurological outcome and a low recurrence rate. Surgery is more complicated in patients with ventral meningiomas. In most cases, unilateral posterior approach is applicable for both ventral and dorsal meningiomas.
Spine surgery in children: past, present and future
Authors: Dubousset J.
Published: April 2021

In accordance with almost 55 years of experience in pediatric spine surgery, it is easy for me to describe the evolution of surgical technique, as well as indications for surgical interventions that were initially performed without the use of any instrumentation (which now are still occasionally considered as useful) through the anterior and posterior approaches, and with postoperative immobilization with plaster braces. The first types of really effective instrumentations were created sequentially by Harrington and Luque, and in parallel with their development, the pedicle screws (Roy-Camille) were introduced into practice. We had to wait another 20 years before the segmental 3D strategy and CD instrumentation appeared, which remain the basis of  modern spinal technologies to this day, regardless of the type of anchoring elements (hooks, screws, universal clamps or hybrid structures). For the present and the future, early interventions remain indicated for local pathological foci, which are usually the result of congenital anomalies with or without spinal cord compression. But for extended deformities, especially of thoracic localization, plaster and removable braces remain a good choice, regardless of the etiology and the presence or absence of pelvic tilt. When such methods did not give the desired result, a lot of efforts were made using various technologies to preserve the growth potentials of the spinal column without impairing respiratory function. At the same time, it was obvious that the incidence of complications was high, and the need for a final fusion was often stated. Hence the emergence of bipolar minimally invasive technologies with very promising results and significant number of patients who developed a spontaneous bone block, made the fusion surgery meaningless. As for older children and adolescents, the race to achieve maximum Cobb angle correction is becoming more controversial. It has been convincingly shown that it is much more important for the future, from the point of view of spinal function, to achieve 3D dynamic balance, which is determined by intervertebral discs located cranial and caudal to the area of surgical fusion.
Cardiovascular health indicators in soccer exercise during adolescence: systematic review
Authors: Nunes Heloyse Elaine Gimenes , Faria Evelinn Amarilha , Martinez Paula Felippe , Oliveira-Júnior Silvio Assis de
Published: April 2021

This review analyzed the studies that evaluated cardiovascular health indicators (blood pressure, waist circumference, heart rate, glucose index and lipid blood) in recreational soccer players during adolescence, and identify possible associated factors. The search was performed in the electronic databases (PubMED, SciELO, LILACS, Scopus, SPORTDiscus and Web of Science). Inclusion criteria were: population composed of children and/or adolescents (10–19 years or average age up to 19 years); studies adolescents engaged in recreational soccer regularly and observational studies with cross-sectional or longitudinal design. The process of analysis of studies involved reading titles, abstracts and full texts. After these phases, seven articles were eligible. Regarding the design, all studies were cross-sectional. Of the total studies included, five presented moderate methodological quality values and two presented low methodological quality values, according to National Heart, Lung, and Blood Institute instrument. The most cardiovascular health indicators used in recreational soccer players during adolescence was waist circumference; three studies analyzed heart rate, two evaluated blood pressure, one analyzed insulin resistance and none of the included studies analyzed lipid profile. Factors associated were analyzed in four studies, being that sedentary time and body mass index (BMI) present association with at least one indicator of cardiovascular health.
Liraglutide combined with intense lifestyle modification in the management of obesity in adolescents
Authors: Apperley Louise J. , Gait Lucy , Erlandson-Parry Karen , Laing Peter , Senniappan Senthil
Published: April 2021

Objectives

Childhood obesity is a public health concern worldwide, with rates continuing to rise, despite preventive measures. Lifestyle modification remains the mainstay in the treatment of patients with excessive weight, but unfortunately, this is not always successful. Options for medical management of obesity in the paediatric population are limited.

Methods

Seven adolescents (all girls, mean age 14.9 years) with a body mass index (BMI) above 98th percentile and serious complications secondary to obesity were offered an intense weight management programme. The participants were reviewed by a multidisciplinary team every two weeks for advice and support, and treated with daily subcutaneous injections of liraglutide (dose range 1.2–3.0 mg). Scores for anxiety and depression were evaluated using the Revised Child Anxiety and Depression Scale.

Results

The results showed a significant weight loss over the three months with an average reduction of 5.4 kg (4.2%; 95% CI 1.93–8.78; p=0.0087). The mean drop in BMI was 2.1 kg/m2, which is statistically significant (95% CI 0.973–3.199; p=0.0037). Resolution of complications (raised intracranial pressure and steatohepatitis) was noted following weight loss. Anxiety and depressive symptoms improved over the three-month intervention course, especially features of separation anxiety disorder. Liraglutide was well tolerated by all patients.

Conclusions

Liraglutide medication, alongside a dedicated multidisciplinary team guided lifestyle therapy, is effective and safe in the treatment for excessive weight in adolescents, leading to the reversal of the complications related to obesity and improvement in the psychological symptoms.
The utility of reverse phenotyping: a case of lysinuric protein intolerance presented with childhood osteoporosis
Authors: Avci Durmusalioglu Enise , Isik Esra , Ayyildiz Emecen Durdugul , Goksen Damla , Ozen Samim , Onay Huseyin , Kose Melis , Atik Tahir , Darcan Sukran , Cogulu Ozgur , Ozkinay Ferda
Published: April 2021

Objectives

Childhood osteoporosis is often a consequence of a chronic disease or its treatment. Lysinuric protein intolerance (LPI), a rare secondary cause of the osteoporosis, is an autosomal recessive disorder with clinical features ranging from minimal protein intolerance to severe multisystemic involvement. We report a case diagnosed to have LPI using a Next Generation Sequencing (NGS) panel and evaluate the utility of reverse phenotyping.

Case presentation

A fifteen-year-old-boy with an initial diagnosis of osteogenesis imperfecta, was referred due to a number of atypical findings accompanying to osteoporosis such as splenomegaly and bicytopenia. A NGS panel (TruSight One Sequencing Panel) was performed and a novel homozygous mutation of c.257G>A (p.Gly86Glu) in the SLC7A7 gene (NM_001126106.2), responsible for LPI, was detected. The diagnosis was confirmed via reverse phenotyping.

Conclusions

Reverse phenotyping using a multigene panel shortens the diagnostic process.
Is overweight/obesity a risk factor for atopic allergic disease in prepubertal children? A case–control study
Authors: Vehapoglu Aysel , Cakın Zeynep Ebru , Kahraman Feyza Ustabas , Nursoy Mustafa Atilla , Toprak Ali
Published: April 2021

Objectives

It is unclear whether body weight status (underweight/normal weight/overweight/obese) is associated with allergic disease. Our objective was to investigate the relationship between body weight status (body mass index; BMI) and atopic allergic disease in prepubertal children, and to compare children with atopic allergic diseases with non atopic healthy children.

Methods

A prospective cross sectional study of 707 prepubertal children aged 3–10 years was performed; the participants were 278 atopic children with physician-diagnosed allergic disease (allergic rhinitis and asthma) (serum total IgE level >100 kU/l and eosinophilia >4%, or positivity to at least one allergen in skin test) and 429 non atopic healthy age- and sex-matched controls. Data were collected between December 2019 and November 2020 at the Pediatric General and Pediatric Allergy Outpatient Clinics of Bezmialem Vakıf University Hospital.

Results

Underweight was observed in 11.6% of all participants (10.8% of atopic children, 12.2% of healthy controls), and obesity in 14.9% of all participants (18.0% of atopic children, 12.8% of controls). Obese (OR 1.71; 95% CI: 1.08–2.71, p=0.021), and overweight status (OR 1.62; 95% CI: 1.06–2.50, p=0.026) were associated with an increased risk of atopic allergic disease compared to normal weight in pre-pubertal children. This association did not differ by gender. There was no relationship between underweight status and atopic allergic disease (OR 1.03; 95% CI: 0.63–1.68, p=0.894).

Conclusions

Overweight and obesity were associated with an increased risk of atopic allergic disease compared to normal weight among middle-income and high-income pre pubertal children living in Istanbul.
Selected types of corrosion degradation of pipelines
Authors: Hagarová M.  , Cervová J. , Jaš F.
Published: April 2021

The paper deals with corrosion degradation of gas pipeline.
Pipelines play very important role as means transporting
gas media over long distances from producers to end-users.
Gas pipelines present a risk of potential corrosion degradation
that can result in their failure. Corrosion on internal surfaces
of steel pipes takes place in CO2, H2S, H2O and chloride environment.
Degradation of steel results in loss of mechanical
properties, reduction in thickness and ultimate perforation and
failure. Corrosion is the electrochemical process that involves
the fl ow of electrical currents on a micro or macro scale. For
corroding steel, the anodic and the cathodic reactions produces
the electrochemical cell. Corrosion protection of internal
pipeline surface is based mainly on chemical composition of
gas and the use of inhibitors. Corrosion protection of the external
steel surface of the product line involves coatings and
cathodic protection.
„Ut unum sint“ – eine bleibende Herausforderung nach 25 Jahren
Authors: Neumann Burkhard
Published: April 2021

In seiner 1995 veröffentlichten Enzyklika „Ut unum sint“ über den Einsatz für die Ökumene macht Papst Johannes Paul II. deutlich, dass sich die römisch-katholische Kirche mit dem II. Vatikanischen Konzil „unumkehrbar“ auf den Weg der Ökumene begeben hat. Vor allem die von ihr ausdrücklich angestoßene Debatte über ein ökumenisch tragfähiges Petrusamt ist bis heute nicht überholt, sondern weiterhin aktuell. Darüber hinaus führt die Enzyklika etwa mit der Betonung des gegenseitigen Lernens, ihrer Theologie des Dialogs oder dem Verweis auf die Ökumene der Märtyrer über die Aussagen des Konzils hinaus und bleibt so eine Herausforderung für den ökumenischen Weg nicht nur der römisch-katholischen Kirche.
The Effect of Mentoring on Employee Job Performance in the Nigerian Service Sector
Authors: Oladimeji Moruff Sanjo , Sowemimo Olatunji Zacchaeus
Published: April 2021

The business world is changing due to the occupational climate and a large proportion of business executives that are bound to retire in the nearest future leading to an anticipated great loss of knowledge and performance. The paper seeks to evaluate job performance by considering the effect of mentoring on employee performance in the Nigerian service sector. Research focuses on finding out the level at which exposure, counseling, and role modelling affect employee performance in the Nigerian service sector.
Psychological Capital (PsyCap) Resources and its Relations with Creative Self-efficacy in Entrepreneurship Students
Authors: Savickaitė-Kazlauskė Evelina
Published: April 2021

This study aims to analyse Psychological Capital (PsyCap) and creative self-efficacy of students participating in the entrepreneurship program. The theory of the paper analyses the development and significance of concepts. Quantitative research focuses on finding out the levels of PsyCap and creative self-efficacy, comparing PsyCap data to a representative sample, comparing all results with the current job status and their entrepreneurial intentions.
Effects of calcium silicate synthesized in situ on Fiber loading and paper properties
Authors: An Yongzhen , Liu Haitang , Liu Jing , Li Xuexiu , Li Jie , Chen Lin , Jin Xin , Xu Yan , Zhao Zhiqiang , Song Shunxi , Hui Lanfeng , Liu Zhong , Huang Yingjian
Published: April 2021

The in-situ synthesis of calcium silicate in the fiber can not only meet the requirements for high loading of paper, but also make up and improve the reduction of paper performance caused by filling. In this investigation, the effects of pulp type, beating degree, fiber ratio, reaction time, rotational speed, dosage of lime milk and dispersant on calcium silicate loading and paper properties were investigated. The results showed that when the beating degree was 40 °SR, the ratio of softwood and hardwood pulp was 1:1, the reaction time was 60 min, the rotation speed was 600 r·min−1, the dosage of lime milk was 1.33 times of the theoretical amount, and the dosage of cationic polyacrylamide was 0.3 % (absolutely dry pulp), the ash content of hand-made sheet was 41.2 %, and the loading amount of calcium silicate was 26.3 %. Under this condition, the comprehensive performance of paper was the best.
Synthesis of a new organic probe 4-(4 acetamidophenylazo) pyrogallol for spectrophotometric determination of Bi(III) and Al(III) in pharmaceutical samples
Authors: Ammar Jumana W. , Khan Zainab A. , Ghazi Marwa N. , Naser Naser A.
Published: April 2021

A modern development discusses the synthesis and validity of simple, sensitive, and versatile spectrophotometric methods for Bi(III) and Al(III) determination in pharmaceutical formulations have been conducted. In the present paper, 4-(4 acetamidophenylazo) pyrogallol has been synthesized as a new organic compound, 4-APAP, by coupling pyrogallol in a regulated pH medium with diazotized p-aminoacetanilide. 4-APAP was identified by methods of FT-IR, 1H-NMR, 13C-NMR, and thermal analysis (thermogravimetry and differential scanning calorimetry). Solvatochromic activity was also studied in solvents with different polarities. The Kamlet and Taft linear solvation energy relationship was used to correlate shifts in UV-Visible spectra of 4-APAP with Kamlet-Taft parameters (α, β, and π*). The optimum assay conditions showed linearity from 0.3–13 to 0.5–11 μg·mL−1 for Bi(III) and Al(III), respectively. Molar absorptivity values were 3.365 × 104 and 0.356 × 104 L·mol−1·cm−1 for Bi(III) and Al(III), with similar Sandell's sensitivity measures of 0.006 and 0.008 μg·cm−2. Detection limits and quantification limits were 0.013 and 0.043 μg·mL−1 for Bi(III), respectively, and 0.018 and 0.059 μg·mL−1 for Al(III) with the relative standard deviation for determination of both metal ions using 4-APAP probe being <2.0%. The validity, accuracy, and efficiency of the approaches were demonstrated by the determination of Bi(III) and Al(III) in different formulations.
Parasitic architecture
Authors: Baroš Tomáš , Katunský Dušan
Published: April 2021

This paper could be considered as a general overview of current examples of realization, research, in architecture which could be called parasitic. Also, as an outline of possible new perspectives on current issues through the biomimicry design philosophy. The aim was also to clearly articulate the intent of the research I am dealing with while opening up a discourse on the subject.
Drought indices and trend analysis
Authors: Nagy Patrik , Zeleňáková Martina
Published: April 2021

In recent times, extremely dry seasons have been occurring more and more often in the eastern Slovakia, alternating with extremely wet seasons like torrential floods from extreme rainfall. Trend of reconnaissance drought index (RDI) and streamflow drought index (SDI) was evaluated in the paper using the Mann-Kendall test. The indices were evaluated at six climatic and river stations in the eastern Slovakia. The Mann-Kendal test results showed that the trend in the SDI index is not significant in 5 stations and only in one station the trend is significant. In the RDI index the trend is not significant in four stations and the trend is significant in two stationshe abstract is to indicate the subject of the paper, how the author proposes to develop the subject and its overall objective, aim or outcome.
Evaluation of biological activities ofBarbarea integrifoliaand isolation of a new glucosinolate derivated compound
Authors: Badem Merve , Sener Sıla Ozlem , Kanbolat Seyda , Korkmaz Nuriye , Yildirmiş Sermet , Ozgen Ufuk , Aliyazicioglu Rezzan , Salva Emine , Kaban Kübra , Kandemir Ali , Calıs İhsan
Published: April 2021

The aim of the present study is to determine the potent biological activities and carry out isolation studies onBarbarea integrifolia. The antioxidant capacity of the species was evaluated by total phenolic content, FRAP, CUPRAC, and DPPH radical scavenging activity. Anticancer activity studies were performed by MTT assay in MDA-MB-231, MCF-7, Hep3B, PC-3, A549, HCT116, L-929 cell lines. It was observed that the remaining aqueous fraction has higher total phenolic content while higher activity in the CUPRAC and FRAP assays was displayed for the methanolic extract and chloroform fraction. The extracts showed anticancer activity as compared with vincristine. It was observed that chloroform fraction has the highest anticancer activity on MCF-7 cell line, while ethyl acetate fraction has the highest anticancer activity on Hep-3B and A549 cell lines. Methanolic extract has the highest anticancer activity on HCT116 and MDA-MB-23 cell lines. The isolation studies have been performed using several chromatographic methods. The chemical structures of compounds have been identified by means of1H NMR,13C NMR, 2D-NMR, and MS. Five major compounds, one steroid (β-Sitosterol), one phenolic acid (Rosmarinic acid), one flavonol heteroside (kaempferol 7-O-α-l-rhamnoside-3-O-β-d-(2-O-β-d-glucosyl)-β-d-glucoside), and two glucosinolates (Gluconasturtiin, Gluconasturtiin choline salt) have been isolated.
Projections of the urban and intra-urban scale thermal effects of climate change in the 21st century for cities in the Carpathian Basin
Authors: Gál Tamás , Skarbit Nóra , Molnár Gergely , Unger János
Published: April 2021

This study evaluates the pattern of a nighttime climate index namely the tropical nights (Tmin ≥ 20ºC) during the 21st century in several different sized cities in the Carpathian Basin. For the modelling, MUKLIMO_3 microclimatic model and the cuboid statistical method were applied. In order to ensure the proper representation of the thermal characteristics of an urban landscape, the Local Climate Zone (LCZ) system was used as landuse information. For this work, LCZ maps were produced using WUDAPT methodology. The climatic input of the model was the Carpatclim dataset for the reference period (1981–2010) and EURO-CORDEX regional model outputs for the future time periods (2021–2050, 2071–2100) and emission scenarios (RCP4.5, RCP8.5). As results show, there would be a remarkable increase in the number of tropical nights along the century, and there is a clearly recognizable increase owing to urban landform. In the near past, the number of the index was 6–10 nights higher in the city core than the rural area where the number of this index was negligible. In the near future this urban-rural trend is the same, however, there is a slight increase (2–5 nights) in the index in city cores. At the end of the century, the results of the two emission scenarios become distinct. In the case of RCP4.5 the urban values are about 15–25 nights, what is less stressful compared to the 30–50 nights according to RCP8.5. The results clearly highlight that the effect of urban climate and climate change would cause serious risk for urban dwellers, therefore it is crucial to perform climate mitigation and adaptation actions on both global and urban scales.
Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma
Authors: Stenman Adam , Backman Samuel , Johansson Klara , Paulsson Johan O , Stålberg Peter , Zedenius Jan , Juhlin C Christofer
Published: April 2021

Pediatric papillary thyroid carcinomas (pPTCs) are often indolent tumors with excellent long-term outcome, although subsets of cases are clinically troublesome and recur. Although it is generally thought to exhibit similar molecular aberrancies as their counterpart tumors in adults, the pan-genomic landscape of clinically aggressive pPTCs has not been previously described. In this study, five pairs of primary and synchronously metastatic pPTC from patients with high-risk phenotypes were characterized using parallel whole-genome and -transcriptome sequencing. Primary tumors and their metastatic components displayed an exceedingly low number of coding somatic mutations and gross chromosomal alterations overall, with surprisingly few shared mutational events. Two cases exhibited one established gene fusion event each (SQSTM1-NTRK3 and NCOA4-RET) in both primary and metastatic tissues, and one case each was positive for a BRAF V600E mutation and a germline truncating CHEK2 mutation, respectively. One single case was without apparent driver events and was considered as a genetic orphan. Non-coding mutations in cancer-associated regions were generally not present. By expressional analyses, fusion-driven primary and metastatic pPTC clustered separately from the mutation-driven cases and the sole genetic orphan. We conclude that pPTCs are genetically indolent tumors with exceedingly stable genomes. Several mutations found exclusively in the metastatic samples which may represent novel genetic events that drive the metastatic behavior, and the differences in mutational compositions suggest early clonal divergence between primary tumors and metastases. Moreover, an overrepresentation of mutational and expressional dysregulation of immune regulatory pathways was noted among fusion-positive pPTC metastases, suggesting that these tumors might facilitate spread through immune evasive mechanisms.
Visualizing Kitchener: Geocoding Historical Street Information
Authors: Dodsworth Eva , Wieland Markus , Pilozo-Hibbit Nolan
Published: April 2021

When studying and investigating the history of a property or neighbourhood, common resources often sought by researchers include air photos, fire insurance plans and historical maps. These will provide information about what an area looked like, often offering the building’s footprint and surrounding landscape. Timespan studies will no doubt show growth, development and possibly changes to the buildings of interest. But what the rich resources don’t tell the researcher is information about the people connected to those buildings. Who lived or worked there? What did they do for a living? Did they move often? Did they change jobs regularly? These types of questions can’t be answered with just maps alone as they require a detailed census to go along with it. To fill this type of need, Geospatial Centre staff at the University of Waterloo Library embarked on a massive-scale digitization and geo-location city directory project – one that had started in 2019, has involved at least 40 staff members, and still has a couple years to go before completion. This paper will summarize the project thus far, with a focus on the journey of geocoding historical streets.
Concept of system of computer virtual simulation of mobile robototechnical means of technical and environmental events neutralization and solving problems of professional training
Authors:   National Technical University ", A. Koval ,   Kyiv Polytechnic Institute''
Published: April 2021

Today, the problem of virtual design, modeling and testing of mobile robots prior to their direct implementation «in the metal» is quite urgent. The article reviews the technologies used for this purpose and discusses the approach to creating specialized software complexes aimed at solving existing problems in existing technologies. The concept of the program is proposed for modeling problems of structure and behavior of mobile robots with elements of artificial intelligence, intended to support search and rescue operations in a combination of environments (air, ground, underwater) and for the professional training of relevant specialists.
The smart urban transport system based on robotic vechicles
Authors:   Brest State Technical University, V.N. Shuts , A.V. Shviatsova ,   Brest State Technical University
Published: April 2021

This article is devoted to the description of an intelligent urban transport passenger system based on unmanned electric vehicles called infobuses, and the principles of its functioning, namely, a conveyor-cassette method of transporting passengers. The introduction describes the prerequisites for the emergence of new types of transport systems in cities and in particular PRT transport
Analysis of the wagons-tanks technical condition of the chemical industry park
Authors:   Priazovsky State Technical University, V. Voropai , V. Chebanov ,   Institute of artificial intelligence problems of MES and NAS of Ukraine
Published: April 2021

The article brings statistical data on the technical condition of the wagons-tanks of one of the largest enterprises of the Ukrainian chemical industry. The technique of monitoring the technical condition is explained, the classification of damage to wagons-tanks depending on the stages of the life cycle is proposed, the distribution of damage depending on the stages of the life cycle is shown. The information set forth in the article provides the basis for conducting technical diagnostics in order to justify the further term of maintenance
Нелокальне рівняння стану: критичні явища та колективне збудження
Authors: Bulavin L.A. , Gavryushenko D.A. , Sysoev V.M.
Published: April 2021

Показано, що в широкому iнтервалi змiни термодинамiчних параметрiв термiчне рiвняння стану рiдинної системи набуває нелокальних властивостей. Побудованi на основi нелокального рiвняння стану профiлi густини рiдини дозволяють визначити, що при наближеннi до критичної точки рiдина–пара суттєва змiна густини системи має мiсце у значнiй частинi об’єму. Застосування нелокального термiчного рiвняння стану для замикання рiвнянь класичної гiдродинамiки дозволяє одержати спектр колективних збуджень, подiбний до спектра збуджень у рiдинному гелiї.
Твірна функція моментів для статистики вихідної активності інтегруючого нейрона з втратами
Authors: Vidybida A.K. , Shchur O.V.
Published: April 2021

Дослiджується статистика вихiдної активностi нейрона при його стимуляцiї потоком вхiдних iмпульсiв, що утворюють стохастичний процес Пуассона. В ролi моделi нейрона взято iнтегруючий нейрон з втратами. Знайдено нове представлення функцiї розподiлу ймовiрностей довжин вихiдних мiжiмпульсних iнтервалiв. На його основi обчислено в явному виглядi твiрну функцiю моментiв ймовiрнiсного розподiлу. Остання, за теоремою Куртiса, повнiстю визначає сам розподiл. Зокрема, на основi твiрної функцiї знайдено явнi вирази для моментiв всiх порядкiв. Момент першого порядку збiгається iз знайденим ранiше. Формули для моментiв другого i третього порядкiв перевiрено чисельно шляхом прямого моделювання стохастичної динамiки нейрона з конкретними фiзичними параметрами.
Antigen-presenting cell-derived extracellular vesicles in accelerating atherosclerosis
Authors: Berezin Alexander E , Berezin Alexander A
Published: April 2021

Extracellular vesicles (EVs) are a population of heterogeneous particles that originate from the endosomal system or plasma membrane. Antigen-presenting cells (APCs) produce and release a broad spectrum of EVs involved in the pathogenesis of atherosclerosis. APC-derived EVs contain several bioactive molecules, such as non-coding RNAs, cytokines, chemokines, active proteins, immunomodulatory factors, and growth factors. The review focuses on the role of APC-derived EVs in regulating the transformation of macrophage phenotype, shaping foam cells, driving autophagy and/or inhibiting apoptosis of Th4+ cells, T regulatory cells, endothelial and smooth muscle cells (SMCs), as well as in facilitating oxidative stress in vasculature. APC-derived EVs act as triggers of angiogenesis, neovascularization and inflammation through their participation in microvascular inflammation, angiogenesis, development of atherosclerotic plaques, and modulation of their instability.
Antioxidant and anti-Helicobacter pylori activities of Hericium erinaceus mycelium and culture filtrate
Authors: Thi My Ngan Luong , Thien Vi Nguyen , Thi Mong Tham Doan , Thi Thanh Loan Le , Thanh Ho Pham , Trung Hieu Tran
Published: April 2021

Introduction: Hericium erinaceus is known as a medicinal edible mushroom owing to its antimicrobial, antioxidant, anti-tumor and immunomodulatory effects. Helicobacter pylori infection is one of the major health concerns worldwide due to its high rate in global populations, frequent recurrence, and rapid emergence of drug-resistant strains. The present study aims to investigate antioxidant anti-H. pylori and urease inhibitory activities of solvent fractions from H. erinaceus mycelium and culture filtrate.
Methods: H. erinaceus mycelium was purely cultured in a liquid medium. A polysaccharide fraction was obtained from the culture filtrate by precipitation with ethanol. The mycelium and culture filtrate were extracted by liquid extraction to obtain solvent-soluble fractions. The antibacterial effects of these fractions were determined using paper disc diffusion and broth microdilution assays. Urease inhibition was determined using the salicylate-hypochlorite method. The antioxidant activity of H. erinaceus was evaluated via 2,2,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.
Results: The ethyl-acetate (EtOAc) fractions derived from H. erinaceus culture filtrate (fEtOAc Fr.) and mycelium (mEtOAc Fr.) showed the strongest anti-H. pylori activity with MIC (MBC) of 1.25 – 1.5 (5.0 – 7.5) mg/mL and potential urease inhibitory activity with IC50 of 0.34 – 0.35 mg/mL. In addition, fEtOAc Fr. exhibited the greatest antioxidant activity (IC50, 11.83 mg/mL), which was slightly stronger than that of mEtOAc Fr. (IC50, 14.75 mg/mL). Moreover, our study also found that the water fractions from the culture filtrate (fWater Fr.) and the mycelium (mWater Fr.) displayed considerable inhibitory activities against bacterial urease (IC50, 1.26 – 1.40 mg/mL), although they had low or no anti-H. pylori activities and low antioxidant properties.
Conclusion: The present study revealed that the EtOAC fractions derived from the H. erinaceus mycelium and culture filtrate potentially have anti-H. pylori, anti-urease and antioxidant activities. These results suggest that H. erinaceus mycelium and culture filtrate could be utilized to develop functional foods and nutraceuticals to prevent H. pylori infection. More research is needed to prove the safety of the H. erinaceus mycelium and culture filtrate fractions and their in vivo efficacy in the treatment of H. pylori infection.