bluuebunny/crossref_metadata_2025 huggingface dataset:
Recommendations for Internal Communication to Strengthen the Employer Brand: A Systematic Literature Review
Authors: Santos Sara , Augusto Luísa , Ferreira Sónia , Espírito Santo Pedro , Vasconcelos Maria
Published: October 2023

The increasingly intense competition in organisations means that they have to develop strategies to differentiate themselves. One of these strategies consists of using internal communication to improve the company’s attractiveness to outside talent and increase its attractiveness to its existing employees. However, this relationship still needs to be studied in the existing literature. This review aims to find and understand the main recommendations to be used in internal communication to improve employer branding. Nine open access scientific articles published between 2013 and 2023 on Scopus and Web of Science, written in English, met the inclusion criteria. Internal communication has been proven to play a crucial role in employer branding. The review presents a series of guidelines that can be incorporated into internal communication to strengthen the employer brand. These relate to communication qualities, knowing how to listen to and respect employees, maintaining responsiveness, providing feedback and the flow of company-related information, and choosing the appropriate communication channels. This study contributes to the ongoing scientific community by summarising and exploring the literature from the past decade. Its findings enhance our understanding of this field of study and strongly advocate for future research.
Visual Detection of Lost Ear Tags in Breeding Pigs in a Production Environment Using the Enhanced Cascade Mask R-CNN
Authors: Wang Fang , Fu Xueliang , Duan Weijun , Wang Buyu , Li Honghui
Published: October 2023

As the unique identifier of individual breeding pigs, the loss of ear tags can result in the loss of breeding pigs’ identity information, leading to data gaps and confusion in production and genetic breeding records, which can have catastrophic consequences for breeding efforts. Detecting the loss of ear tags in breeding pigs can be challenging in production environments due to factors such as overlapping breeding pig clusters, imbalanced pig-to-tag ratios, and relatively small-sized ear tags. This study proposes an improved method for the detection of lost ear tags in breeding pigs based on Cascade Mask R-CNN. Firstly, the model utilizes ResNeXt combined with a feature pyramid network (FPN) as the feature extractor; secondly, the classification branch incorporates the online hard example mining (OHEM) technique to improve the utilization of ear tags and low-confidence samples; finally, the regression branch employs a decay factor of Soft-NMS to reduce the overlap of redundant bounding boxes. The experiment employs a sliding window detection method to evaluate the algorithm’s performance in detecting lost ear tags in breeding pigs in a production environment. The results show that the accuracy of the detection can reach 92.86%. This improvement effectively enhances the accuracy and real-time performance of lost ear tag detection, which is highly significant for the production and breeding of breeding pigs.
Comparison of Fruit Parameters and Elemental Composition of Commercial Varieties of Blackberries
Authors: Ladyzhenskaya Olga , Aniskina Tatiana , Kryuchkova Viktoriya , Simakhin Maxim
Published: October 2023

Blackberries are a valuable crop that has a positive effect on human health due to its fruits’ antioxidant and antihyperglycemic properties. The main goal of the research was to compare the fruit parameters of modern blackberry varieties. The experiment involved six varieties of blackberries: ‘Natchez’, ‘Loch Tay’, ‘Brzezina’, ‘Black Gem’, ‘Heaven Can Wait’, and ‘Ouachita’. The data were collected in 2021–2022 in the Rostov region of Russia. On one hectare, 3000 plants with trellises were planted. To prevent winter damage, the plants were covered for the winter period with a non-woven covering material with a density of 60 g/m2. To assess the quality of the fruits, harvesting was carried out from seven to nine in the morning once every 5–6 days. The results showed that the most productive varieties are the ‘Loch Tay’ (4.8 kg/bush), ‘Black Gem’ (4.2 kg/bush), ‘Heaven Can Wait’ (3.9 kg/bush), and ‘Ouachita’ (3.8 kg/bush) varieties. The heaviest fruits are as follows: ‘Natchez’ (13.3 g), ‘Black Gem’ (11.2 g), and ‘Ouachita’ (10.3 g). The varieties with the highest amount of sugar are the following: ‘Black Gem’ (14.7 Brix), ‘Ouachita’ (13.4 Brix), ‘Loch Tay’ (12.9 Brix), and ‘Heaven Can Wait’ (11.6 Brix). In terms of the combination of the parameters, the most promising varieties for industrial production in this region are the ‘Ouachita’, ‘Black Gem’, ‘Loch Tay’, and ‘Heaven Can Wait’ varieties. Medium and strong relationships were established between the parameters of the fruits and the elemental composition of the leaves. During the study, we also developed systems of equations for predicting the parameters of a berry based on the content of one or another macro and microelement of a leaf; these systems are suitable for both the manual calculations in nurseries and the correcting of programs for the automated determination of fruit quality and the calculation of productivity in large industrial farms. The obtained data will make it possible to increase the blackberry production area in Russia from 4.34% to 22.06% in various growing regions.
First Detection of Theileria sinensis-like and Anaplasma capra in Ixodes kashmiricus: With Notes on cox1-Based Phylogenetic Position and New Locality Records
Authors: Numan Muhammad , Alouffi Abdulaziz , Almutairi Mashal M. , Tanaka Tetsuya , Ahmed Haroon , Akbar Haroon , Rashid Muhammad Imran , Tsai Kun-Hsien , Ali Abid
Published: October 2023

Ixodes ticks transmit Theileria and Anaplasma species to a wide range of animals. The spreading of ticks and tick-borne pathogens has been attributed to transhumant herds, and research on these uninvestigated issues has been neglected in many countries, including Pakistan. Recently, we used internal transcribed spacer (ITS) and 16S ribosomal DNA partial sequences to genetically characterize Ixodes kashmiricus ticks and their associated Rickettsia spp. However, the data on its cox1 sequence and associated Theileria spp. and Anaplasma spp. are missing. This study aimed to genetically characterize I. kashmiricus based on the cox1 sequence and their associated Theileria spp. and Anaplasma spp. The I. kashmiricus ticks were collected from small ruminants: sheep (Ovis aries) and goats (Capra hircus) of transhumant herds in district Shangla, Dir Upper and Chitral, Khyber Pakhtunkhwa (KP), Pakistan. Out of 129 examined hosts, 94 (72.87%) (56 sheep and 38 goats) were infested by 352 ticks, including adult females (175; 49.7%) followed by nymphs (115; 32.7%) and males (62; 17.6%). For molecular analyses, 121 ticks were subjected to DNA isolation and PCR for the amplification of the cox1 sequence for I. kashmiricus, 18S rDNA for Theileria spp. and 16S rDNA sequences for Anaplasma spp. The obtained cox1 sequence showed 89.29%, 88.78%, and 88.71% identity with Ixodes scapularis, Ixodes gibbosus, and Ixodes apronophorus, respectively. Phylogenetically, the present cox1 sequence clustered with the Ixodes ricinus complex. Additionally, the 18S rDNA sequence showed 98.11% maximum identity with Theileria cf. sinensis and 97.99% identity with Theileria sinensis. Phylogenetically, Theileria spp. clustered with the T. cf. sinensis and T. sinensis. In the case of Anaplasma spp., the 16S rDNA sequence showed 100% identity with Anaplasma capra and phylogenetically clustered with the A. capra. PCR-based DNA detection targeting the amplification of groEL and flaB sequences of Coxiella spp. and Borrelia spp., respectively, was unsuccessful. This is the first phylogenetic report based on cox1 and new locality records of I. kashmiricus, and the associated T. sinensis-like and A. capra. Significant tick surveillance studies are needed in order to determine the epidemiology of Ixodes ticks and their associated pathogens.
Climate Adaptation and Drift Shape the Genomes of Two Eel-Goby Sister Species Endemic to Contrasting Latitude
Authors: Lü Zhenming , Liu Tianwei , Liu Yantao , Wang Yuzhen , Liu Jing , Liu Bingjian , Gong Li , Liu Liqin
Published: October 2023

Deciphering the role of climate adaptation in generating genetic divergence and hence speciation is a central question in evolution. Comparisons of genomes of closely related species spanning selective climate gradients are particularly informative in discerning the signatures of selection and thereby providing valuable information concerning the role of climate adaptation in speciation. Here we re-sequenced 99 genomes of the two sister eel-goby species Odontamblyopus lacepedii and O. rebecca, which are endemic to tidal mudflats spanning contrasting latitude gradients, to estimate the influence of divergent climate selection on shaping genome-wide patterns of divergence. The results indicated that genome-wide differentiation between the two species was evident (genome-wide FST = 0.313). Against a background of high baseline genomic divergence, 588 and 1202 elevated divergent loci were detected to be widespread throughout their genomes, as opposed to focused within small islands of genomic regions. These patterns of divergence may arise from divergent climate selection in addition to genetic drift acting through past glacial segregation (1.46 million years ago). We identified several candidate genes that exhibited elevated divergence between the two species, including genes associated with substance metabolism, energy production, and response to environmental cues, all putative candidates closely linked to thermal adaptation expected from the latitude gradient. Interestingly, several candidates related to gamete recognition and time of puberty, and also exhibited elevated divergence, indicating their possible role in pre-zygote isolation and speciation of the two species. Our results would expand our knowledge on the roles of latitude climate adaptation and genetic drift in generating and maintaining biodiversity in marine teleosts.
Implications of ZnO Nanoparticles and S-Nitrosoglutathione on Nitric Oxide, Reactive Oxidative Species, Photosynthetic Pigments, and Ionomic Profile in Rice
Authors: Lourenço Isabella Martins , Freire Bruna Moreira , Pieretti Joana Claudio , Reis Roberta Albino dos , Soares Nicolas Martins , Santos Marcelo da Luz , Batista Bruno Lemos , Seabra Amedea Barozzi , Lange Camila Neves
Published: October 2023

Zinc is an important nutrient for several plants and humans. Nitric oxide (NO) is a free radical that is important to biological processes that mediate the growth and mitigation of biotic and abiotic stresses in plants. The present study investigated the enzymatic and photosynthetic profile and the accumulation of macro- and microelements in rice plants (Oryza sativa L.) that received foliar treatments of zinc oxide nanoparticles (ZnO NPs), nitric oxide donor (GSNO), and the association of both (GSNO–ZnO NPs). Zinc concentration in rice husks increased by 66% and 68% in plants treated with ZnO NPs and GSNO–ZnO NPs, respectively. The GSNO treatment caused an increase of 25% in the Fe concentration in the rice grains. Only a small disturbance of the antioxidant system was observed, with increases in H2O2, S-NO, and NO2−, mainly in the group treated with GSNO–ZnO NPs; however, the disturbance did not affect the yield, the growth, or vital processes, such as as photosynthetic pigments production. There was an increase in chlorophyll B of 290% and an increase in chlorophyll A of 187% when ZnO NPs was applied. GSNO–ZnO NPs increased chlorophyll B by 345% and chlorophyll A by 345%, indicating that the treatments GSNO, ZnO NPs, and GSNO–ZnO NPs reduced possible oxidative stress and helped as protective treatments.
Antibacterial and Cytotoxic Potential of Latex-Mediated Silver Nanoparticles Using Tabernaemontana ventricosa
Authors: Naidoo Clarissa Marcelle , Naidoo Yougasphree , Dewir Yaser Hassan , Singh Moganavelli , Daniels Aliscia Nicole , Lin Johnson , Alsughayyir Ali
Published: October 2023

The recent developments in nanotechnology have driven researchers towards the application of latex extracts for the green synthesis of silver nanoparticles (AgNPs). In this study, AgNPs were biologically synthesized using latex extracts from Tabernaemontana ventricosa, characterized, and their respective biological activities were assessed. Our results showed prominent silver (Ag) peaks at 410 nm confirmed by UV-vis while the elemental percentage composition (3.89 ± 0.16%) of the AgNPs was verified by EDX. The SEM and HRTEM analysis revealed spherical, ovate, and triangular AgNPs, with diameters ranging from 5.00 nm–17.50 nm; however, larger hydrodynamic diameters were revealed by NTA analysis. The FTIR spectra results displayed several peaks of bending and stretching associated with various functional groups such as alcohols, alkanes, amines, proteins, enzymes, and other biomolecules possibly responsible for the capping, reduction, and functionalization of AgNPs. In addition, the AgNPs showed strong antibacterial activity (diameter of the zone of inhibition) against Escherichia coli (12.67 ± 1.15 mm), Staphylococcus aureus (11.67 ± 0.58 mm), and Pseudomonas aeruginosa (11.33 ± 0.58 mm), with significant cytotoxic activity noted in the HeLa cells (10.52 µg/mL). The study confirmed the successful production of AgNPs and recommends T. ventricosa latex extracts as effective capping agents of nanoparticles (NPs).
Influence of Heterogeneity of Salt Content in Food Structure on the Sensory Profile and Consumer Perception of Beef Burgers
Authors: Głuchowski Artur , Crofton Emily , Baby Limin M. , O’Sullivan Maurice G. , Kerry Joe P. , Hamill Ruth M.
Published: October 2023

Contrast stimuli created between high- and low-taste concentration zones have been shown to enhance the perception of sensory trait intensity. The objective of this study was to determine if layering beef formulations with contrasting salt contents in salt-heterogeneous burger patties could evoke a more intense perception of sensory flavours compared to a burger matched in overall salt content but with a homogeneous salt distribution. The study material consisted of one patty batch with a homogeneous salt distribution (HM 0.7% NaCl) and six patty batches with an average NaCl content of 0.7% but distributed in six different heterogeneous (HT) salt structures. Sensory profiling and consumer tests in a group of 105 Irish residents were performed. The heterogeneity of salt in beef patties produced significant differences (p ≤ 0.05) among formulations in the intensity of salty taste, salty and beefy aftertaste, and taste uniformity. An analysis of the proximate composition of the burgers showed that the raw burgers did not differ in their moisture, protein, or fat contents, while the cooked ones did not differ in their salt contents. The results of a hedonic assessment of beef burgers with varied spatial distributions of salt did not show any significant differences in the liking of any sensory traits. Our data suggest an alternative approach involving preparing burgers with layers of varied salt concentrations with similar sensory experiences while potentially facilitating lower salt inclusion levels.
Natural Language Processing: Recent Development and Applications
Authors: Chang Kuei-Hu
Published: October 2023

Natural Language Processing (NLP) can be categorized into the subfields of artificial intelligence (AI) and linguistics [...]
YOLOv7-3D: A Monocular 3D Traffic Object Detection Method from a Roadside Perspective
Authors: Ye Zixun , Zhang Hongying , Gu Jingliang , Li Xue
Published: October 2023

Current autonomous driving systems predominantly focus on 3D object perception from the vehicle’s perspective. However, the single-camera 3D object detection algorithm in the roadside monitoring scenario provides stereo perception of traffic objects, offering more accurate collection and analysis of traffic information to ensure reliable support for urban traffic safety. In this paper, we propose the YOLOv7-3D algorithm specifically designed for single-camera 3D object detection from a roadside viewpoint. Our approach utilizes various information, including 2D bounding boxes, projected corner keypoints, and offset vectors relative to the center of the 2D bounding boxes, to enhance the accuracy of 3D object bounding box detection. Additionally, we introduce a 5-layer feature pyramid network (FPN) structure and a multi-scale spatial attention mechanism to improve feature saliency for objects of different scales, thereby enhancing the detection accuracy of the network. Experimental results demonstrate that our YOLOv7-3D network achieved significantly higher detection accuracy on the Rope3D dataset while reducing computational complexity by 60%.
The Number of Zeros in a Disk of a Complex Polynomial with Coefficients Satisfying Various Monotonicity Conditions
Authors: Gardner Robert , Gladin Matthew
Published: October 2023

Motivated by results on the location of the zeros of a complex polynomial with monotonicity conditions on the coefficients (such as the classical Eneström–Kakeya theorem and its recent generalizations), we impose similar conditions and give bounds on the number of zeros in certain regions. We do so by introducing a reversal in monotonicity conditions on the real and imaginary parts of the coefficients and also on their moduli. The conditions imposed are less restrictive than many of those in the current literature and hence apply to polynomials not covered by previous results. The results presented naturally apply to certain classes of lacunary polynomials. In particular, the results apply to certain polynomials with two gaps in their coefficients.
Evaluation of Ten Fresh Snow Density Parameterization Schemes for Simulating Snow Depth and Surface Energy Fluxes on the Eastern Tibetan Plateau
Authors: Li Wenjing , Luo Siqiong , Wang Jingyuan , Wang Yuxuan
Published: October 2023

Snow cover on the Tibetan Plateau has a shallow depth, plaque distribution, and repeated ablation. The applicability of the snow parameterization scheme in the current land surface process model on the TP needs to be further tested using observational data. In this paper, using the land surface process model CLM4.5 and ten fresh snow density parameterization schemes characterized by temperature, wind speed, and relative humidity, three discontinuous snow processes in Maqu, Madoi, and Yakou and two continuous snow processes in Madoi and Yakou were simulated. By comparing the simulated snow depth with the observed, it was found that this model can clearly describe repeated snow accumulation and ablation processes for the discontinuous snow cover process. The KW scheme, compared with the original Anderson scheme, performed the best regarding snow depth simulation. However, all schemes overestimated the melting rate of snow, and were not able to simulate continuous snow accumulation. The simulation effect of the Schmucki scheme on radiation and energy flux under discontinuous snow cover was significantly improved compared with other scheme. None of schemes performed perfectly, so future studies that focus on the simulations of snow depth, radiation flux, and energy flux under continuous snow cover for accurate and wide applications are recommended.
Generalized Refinements of Reversed AM-GM Operator Inequalities for Positive Linear Maps
Authors: Ren Yonghui
Published: October 2023

We shall present some more generalized and further refinements of reversed AM-GM operator inequalities for positive linear maps due to Xue’s and Ali’s publications.
Comparison of Antibody Responses against Two Molecules from Ascaris lumbricoides: The Allergen Asc l 5 and the Immunomodulatory Protein Al-CPI
Authors: Ahumada Velky , Zakzuk Josefina , Aglas Lorenz , Coronado Sandra , Briza Peter , Regino Ronald , Ferreira Fátima , Caraballo Luis
Published: October 2023

Immunity to Ascaris lumbricoides influences the pathogenesis of allergic diseases. Antibody responses to its proteins have been found to be associated with asthma presentation; however, helminth products that induce immunosuppression have been reported, which also raise specific antibodies. We aimed to evaluate antibody responses (IgE, IgG4 and IgG) to two A. lumbricoides molecules, Asc l 5 and Al-CPI (an anti-inflammatory Cysteine Protease Inhibitor), in an endemic population, exploring their relationships with the infection and asthma. The two molecules were produced as recombinant proteins in E. coli expression systems. Specific antibodies were detected by ELISA. Lower human IgE, but higher IgG4 and IgG antibody levels were observed for Al-CPI than for rAsc l 5. The IgE/IgG4 isotype ratio was significantly higher for Asc l 5 than for Al-CPI. In humans Al-CPI did not induce basophil activation as has been previously described for Asc l 5. In mice, Al-CPI induced fewer IgE responses, but more IgG2a antibody titers than rAsc l 5. Our results suggest that these molecules elicit different patterns of immune response to A. lumbricoides.
Biological Applications of Synthetic Binders Isolated from a Conceptually New Adhiron Library
Authors: D’Ercole Claudia , De March Matteo , Veggiani Gianluca , Oloketuyi Sandra , Svigelj Rossella , de Marco Ario
Published: October 2023

Background: Adhirons are small (10 kDa) synthetic ligands that might represent an alternative to antibody fragments and to alternative scaffolds such as DARPins or affibodies. Methods: We prepared a conceptionally new adhiron phage display library that allows the presence of cysteines in the hypervariable loops and successfully panned it against antigens possessing different characteristics. Results: We recovered binders specific for membrane epitopes of plant cells by panning the library directly against pea protoplasts and against soluble C-Reactive Protein and SpyCatcher, a small protein domain for which we failed to isolate binders using pre-immune nanobody libraries. The best binders had a binding constant in the low nM range, were produced easily in bacteria (average yields of 15 mg/L of culture) in combination with different tags, were stable, and had minimal aggregation propensity, independent of the presence or absence of cysteine residues in their loops. Discussion: The isolated adhirons were significantly stronger than those isolated previously from other libraries and as good as nanobodies recovered from a naïve library of comparable theoretical diversity. Moreover, they proved to be suitable reagents for ELISA, flow cytometry, the western blot, and also as capture elements in electrochemical biosensors.
Extracellular Vesicles Derived from Osteogenic-Differentiated Human Bone Marrow-Derived Mesenchymal Cells Rescue Osteogenic Ability of Bone Marrow-Derived Mesenchymal Cells Impaired by Hypoxia
Authors: Wang Chenglong , Stöckl Sabine , Pattappa Girish , Schulz Daniela , Hofmann Korbinian , Ilic Jovana , Reinders Yvonne , Bauer Richard J. , Sickmann Albert , Grässel Susanne
Published: October 2023

In orthopedics, musculoskeletal disorders, i.e., non-union of bone fractures or osteoporosis, can have common histories and symptoms related to pathological hypoxic conditions induced by aging, trauma or metabolic disorders. Here, we observed that hypoxic conditions (2% O2) suppressed the osteogenic differentiation of human bone marrow-derived mesenchymal cells (hBMSC) in vitro and simultaneously increased reactive oxygen species (ROS) production. We assumed that cellular origin and cargo of extracellular vesicles (EVs) affect the osteogenic differentiation capacity of hBMSCs cultured under different oxygen pressures. Proteomic analysis revealed that EVs isolated from osteogenic differentiated hBMSC cultured under hypoxia (hypo-osteo EVs) or under normoxia (norm-osteo EVs) contained distinct protein profiles. Extracellular matrix (ECM) components, antioxidants and pro-osteogenic proteins were decreased in hypo-osteo EVs. The proteomic analysis in our previous study revealed that under normoxic culture conditions, pro-osteogenic proteins and ECM components have higher concentrations in norm-osteo EVs than in EVs derived from naïve hBMSCs (norm-naïve EVs). When selected for further analysis, five anti-hypoxic proteins were significantly upregulated (response to hypoxia) in norm-osteo EVs. Three of them are characterized as antioxidant proteins. We performed qRT-PCR to verify the corresponding gene expression levels in the norm-osteo EVs’ and norm-naïve EVs’ parent cells cultured under normoxia. Moreover, we observed that norm-osteo EVs rescued the osteogenic ability of naïve hBMSCs cultured under hypoxia and reduced hypoxia-induced elevation of ROS production in osteogenic differentiated hBMSCs, presumably by inducing expression of anti-hypoxic/ antioxidant and pro-osteogenic genes.
Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction
Authors: Rabkin Simon W. , Wong Chenille N.
Published: October 2023

This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca2+-ATPase, oxidative–nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation.
Clinical Use and Treatment Mechanism of Molecular Hydrogen in the Treatment of Various Kidney Diseases including Diabetic Kidney Disease
Authors: Hirano Shin-ichi , Ichikawa Yusuke , Sato Bunpei , Takefuji Yoshiyasu , Satoh Fumitake
Published: October 2023

As diabetes rates surge globally, there is a corresponding rise in the number of patients suffering from diabetic kidney disease (DKD), a common complication of diabetes. DKD is a significant contributor to chronic kidney disease, often leading to end-stage renal failure. However, the effectiveness of current medical treatments for DKD leaves much to be desired. Molecular hydrogen (H2) is an antioxidant that selectively reduces hydroxyl radicals, a reactive oxygen species with a very potent oxidative capacity. Recent studies have demonstrated that H2 not only possesses antioxidant properties but also exhibits anti-inflammatory effects, regulates cell lethality, and modulates signal transduction. Consequently, it is now being utilized in clinical applications. Many factors contribute to the onset and progression of DKD, with mitochondrial dysfunction, oxidative stress, and inflammation being strongly implicated. Recent preclinical and clinical trials reported that substances with antioxidant properties may slow the progression of DKD. Hence, we undertook a comprehensive review of the literature focusing on animal models and human clinical trials where H2 demonstrated effectiveness against a variety of renal diseases. The collective evidence from this literature review, along with our previous findings, suggests that H2 may have therapeutic benefits for patients with DKD by enhancing mitochondrial function. To substantiate these findings, future large-scale clinical studies are needed.
Association between Maternal and Toddler Appetitive Traits in a Mexican Population
Authors: González-Toribio Jocelyn , Hunot-Alexander Claudia , Vásquez-Garibay Edgar Manuel , Larrosa-Haro Alfredo , Casillas-Toral Erika , Curiel-Curiel Carmen Patricia
Published: October 2023

The Child Eating Behaviour Questionnaire for toddlers (CEBQ-T-Mex) and the Adult Eating Behaviour Questionnaire (AEBQ-Esp) measure appetitive traits (ATs) in children and adults, respectively, both validated for use in Spanish. ATs are inherited variations in appetite, present from birth, that are reasonably stable throughout childhood and can explain why some infants over- or undereat in response to environmental exposures. “Food approach” traits predispose to overweight while “food avoidance” traits provide protection, but little is known about the relationships between parents’ and their toddler’s ATs. The aim was to examine the associations between maternal and toddler appetitive traits, using the AEBQ-Esp and CEBQ-T-Mex, and to examine the associations between ATs and Body Mass Index z-scores (BMIz). Sociodemographic data and the weights and heights of mothers and toddlers (aged 12–36 months) were collected from a teaching hospital in Guadalajara, Mexico. Mothers completed both the AEBQ-Esp and the CEBQ-T-Mex. Direct correlations were found between the ATs of toddlers and their mother (p < 0.005), except for “Slowness in Eating” (SE), and only an inverse correlation was found between the “Satiety Responsiveness” (SR) of toddlers and their BMIz (r = −0.147; p = 0.007). These results suggest that ATs could potentially run in families. These may be useful targets for family-wide interventions to support the development and maintenance of healthy eating behaviours in childhood.
Theoretical Analysis of the Influence of Bearing Plate Position on the Bearing Performance of Soil around the CEP Antipull Force Double Pile
Authors: Qian Yongmei , Sun Lin , Ai Lishuang , Zhou Ying , Li Mingxiao
Published: October 2023

With the development of large-scale projects such as high-rise buildings, deep-sea platforms, bridges, etc., these construction facilities are affected by many factors such as environment and geological conditions, which put forward higher requirements for pile-bearing capacity. Compared with the straight-hole grouted piles, the CEP (concrete expanded-plate) piles have an increased bearing plate, which has stronger resistance to pullout under the action of axial tension. The location of the bearing plate is the main factor affecting the bearing capacity of a CEP pile. This study simulates and analyzes CEP double piles on ANSYS software (Ansys R19.0 versions) under ideal conditions, designs five types of model piles with different bearing plate positions, and divides them into six groups for simulation. Finally, a complete model of the two-pile system is established. It is obtained that when the bearing plate is in the same position, the longer the pile length above the bearing plate, the greater the ultimate bearing capacity of the CEP double piles; when the bearing plates of a double pile are at different positions, the antipull-force-bearing capacity of the double pile mainly depends on the pile with a smaller pile length above the bearing plate, and determines the calculation mode of a CEP double-pile antipull-force-bearing capacity at different bearing plate positions, so as to provide a theoretical basis for the design and application of CEP pile foundations in large building structures in the future.
Spatial Feature Analysis of the Beijing Forbidden City and the Shenyang Imperial Palace Based on Space Syntax
Authors: Zhang Dongxu , Shan Xuyang , Zhang Xinyi , Chen Hao , Zheng Yingsheng
Published: October 2023

As two of the most complete existing examples of royal architecture and cultural World Heritage Sites in China, the Beijing Forbidden City and the Shenyang Imperial Palace are distinctive in terms of their spatial organization. This study used the relational diagram method of space syntax theory to quantitatively analyze the spaces of these two palaces. Furthermore, the characteristics of these spaces were explored by comparing the integration and depth value of each palace space, as well as the differences in architectural culture between the different times and nationalities that they reflect. The results show that in the Forbidden City, office space had the lowest degree of spatial enclosure (depth value), while living space had the highest spatial enclosure. Moreover, there was little difference in accessibility (integration value) among office space, living space, and recreation space. In the Shenyang Imperial Palace, the accessibility of office space, living space, and recreation space showed a decreasing trend, while their spatial enclosure showed an increasing trend. The depth values of office space, living space, and recreation space were higher in the Beijing Forbidden City than in the Shenyang Imperial Palace by 245%, 109%, and 35%, respectively. The integration value of office space was 22.2% higher in the Shenyang Imperial Palace than in the Forbidden City, while the integration values of living space and recreation space were higher in the Forbidden City than in the Shenyang Imperial Palace by 13.9% and 49.2%, respectively. The degree of enclosure of the recreation spaces in both palaces was very strong, indicating that the royal family paid attention to privacy during their leisure activities. In the process of use, the functional conversion of different palaces in the Forbidden City significantly improved the accessibility of both the emperor’s living space and the minister’s office space and simultaneously strengthened the connection between these two spaces. Factors in the construction sequence led to the unreasonable accessibility of recreation space in the Shenyang Imperial Palace.
Proton Therapy for Advanced Juvenile Nasopharyngeal Angiofibroma
Authors: Hoeltgen Line , Tessonnier Thomas , Meixner Eva , Hoegen Philipp , Kim Ji-Young , Deng Maximilian , Seidensaal Katharina , Held Thomas , Herfarth Klaus , Debus Juergen , Harrabi Semi
Published: October 2023

Purpose: To provide the first report on proton radiotherapy (PRT) in the management of advanced nasopharyngeal angiofibroma (JNA) and evaluate potential benefits compared to conformal photon therapy (XRT). Methods: We retrospectively reviewed 10 consecutive patients undergoing PRT for advanced JNA in a definitive or postoperative setting with a relative biological effectiveness weighted dose of 45 Gy in 25 fractions between 2012 and 2022 at the Heidelberg Ion Beam Therapy Center. Furthermore, dosimetric comparisons and risk estimations for short- and long-term radiation-induced complications between PRT plans and helical XRT plans were conducted. Results: PRT was well tolerated, with only low-grade acute toxicities (CTCAE I–II) being reported. The local control rate was 100% after a median follow-up of 27.0 (interquartile range 13.3–58.0) months. PRT resulted in considerable tumor shrinkage, leading to complete remission in five patients and bearing the potential to provide partial or complete symptom relief. Favorable dosimetric outcomes in critical brain substructures by the use of PRT translated into reduced estimated risks for neurocognitive impairment and radiation-induced CNS malignancies compared to XRT. Conclusions: PRT is an effective treatment option for advanced JNA with minimal acute morbidity and the potential for reduced radiation-induced long-term complications.
Linkage between Psychological Factors and Response to Immune Checkpoint Inhibitor Therapy: A Preliminary Study
Authors: Cohen Miri , Shamay Yosi , Czamanski-Cohen Johanna , Shulman Katerina , Keren Rosenberg Shoshana , Abu-Amna Mahmoud , Turgeman Ilit , Merkin Livshits Ludmila , Birenboim Revital , Dines Monica , Bar-Sela Gil
Published: October 2023

Substantial evidence has accumulated showing that psychological distress affects immune regulation, the response to cancer treatment, and survival. The effect of psychological parameters on the effectiveness of immune checkpoint inhibitor (ICI) treatment has not yet been studied. This preliminary study aimed to (a) examine the associations between psychological factors and responses to ICI treatment and (b) assess the associations between psychological factors and blood measures of sPD-1, sCTLA-4, and cytokines that may alter the effect of ICI treatment. The participants were 62 individuals with advanced cancer, aged 18 years or older, who were candidates for ICI treatment as a new line of treatment. The participants answered questionnaires and provided blood samples and medical data prior to the start of ICI treatment and 3 months after. Perceived health status was positively associated with better responses to ICI treatment. In the subsample of participants with biomarkers, worse health-related quality of life was associated with higher IL-6 and sCTLA-4; emotional distress and sleep difficulties were associated with higher sCTLA-4; and better perceived health was associated with lower IL-6 and TNFα. sPD-1 was not associated with psychological measures. This preliminary study found for the first time that some psychological measures could be linked to responses to cancer treatment, possibly via pro-inflammatory cytokines and sCTLA-4.
Modeling the Effects of Local Atmospheric Conditions on the Thermodynamics of Sobradinho Lake, Northeast Brazil
Authors: Afonso Eliseu Oliveira , Chou Sin Chan
Published: October 2023

The objective of this work was to study climate variability and its impacts on the temperature of Sobradinho Lake in Northeast Brazil. Surface weather station data and lake measurements were used in this study. The model applied in this work is FLake, which is a one-dimensional model used to simulate the vertical temperature profile of freshwater lakes. First, the climate variability around Sobradinho Lake was analyzed. Observations showed a reduction in precipitation during 1991–2020 compared to 1981–2010. To study climate variability impacts on Sobradinho Lake, the years 2013, 2015, and 2020 were selected to characterize normal, dry, and rainy years, respectively. In addition, the months of January, April, July, and October were analyzed for rainy months, rainy–dry transitions, dry months, and dry–rainy transitions. Dry years showed higher incoming solar radiation at the surface and, consequently, higher 2 m air temperatures. A characteristic of the normal years was more intense surface winds. October presented the highest incoming solar radiation, the highest air temperature, and the most intense winds at the surface. The lowest incoming solar radiation at the surface was observed in January, and the lightest wind was observed in April. To assess the effects of these atmospheric conditions on the thermodynamics of Sobradinho Lake, the FLake model was forced using station observation data. The thermal amplitude of the lake surface temperature (LST) varied by less than 1 °C during the four months. This result was validated against surface lake observations. FLake was able to accurately reproduce the diurnal cycle variation in sensible heat fluxes (H), latent heat fluxes, and momentum fluxes. The sensible heat flux depends directly on the difference between the LST and the air temperature. During daytime, however, Flake simulated negative values of H, and during nighttime, positive values. The highest values of latent heat flux were simulated during the day, with the maximum value was simulated at 12:00 noon. The momentum flux simulated a similar pattern, with the maximum values simulated during the day and the minimum values during the night. The FLake model also simulated the deepest mixing layer in the months of July and October. However, our results have limitations due to the lack of observed data to validate the simulations.
The Use of Vacuum Devices as Adjuvant Therapy before and after Penile Curvature Surgery in Patients Affected by La Peyronie’s Disease: Results from a Comparative Study
Authors: Cai Tommaso , Capece Marco , Ceruti Carlo , Tiscione Daniele , Puglisi Marco , Verze Paolo , Gontero Paolo , Palmieri Alessandro
Published: October 2023

Background: Peyronie’s disease (PD) represents a challenging urological disease, due to not optimal post-operative surgical outcomes. We aim to retrospectively evaluate if vacuum erection device (VED) treatment before penile curvature surgery is able to improve post-operative surgical outcomes. Methods: All enrolled patients were assigned to the following groups: (a) the treatment group: VED treatment (three times per week) starting 3 months before surgery and (three times per week) one month after surgery; and (b) the control group: VED treatment (three times per week) one month after surgery. Follow-up urologic visits were scheduled for 3 and 6 months after surgery, and the two groups were compared. Results: A total of 38 patients were enrolled (median age 67 years, 57–74, IQR): 20 in the treatment group and 18 in the control group. At the follow-up visits, the two groups were different in terms of IIEF-5 (26 vs. 24; p = 0.02), “yes” to SEP2 and 3 (85% vs. 55%; p < 0.001, 85% vs. 50%; p < 0.001, respectively), and PDQ (−16 vs. −11; p = 0.03). Complete correction of penile curvature was achieved in 36 patients (94.7%). In the treatment group, no hourglass deformity was reported, whereas one patient reported a mild hourglass deformity in the control group. In the treatment group, we obtained a longer total penile length (median +1.5 cm). The overall satisfaction rate was 98% in the treatment group and 96% in the control group. Conclusions: The VED treatment before penile curvature surgery in patients affected by PD was able to improve surgical outcomes.
Case Study on the Performance of High-Flowing Steel-Fiber-Reinforced Mixed-Sand Concrete
Authors: Geng Haibin , Zhang Yanyan , Wang Huijuan , Zhong Hao , Li Changyong , Li Fenglan
Published: October 2023

To promote the efficient utilization of bulk solid wastes, including superfine river sand and fly ash, high-flowing steel-fiber-reinforced mixed-sand concrete (SFRMC) was developed in this study. Superfine river sand and coarse manufactured sand were mixed in a proportion of 4:6 to make the mixed sand. Fly ash, with a content of 30~75%, was blended with 0~12% silica fume on the premise of equivalent activity. The water dosage and sand ratio were adjusted with the volume fraction of steel fiber, which varied from 0.4 to 1.6%, to ensure the high flowability of fresh SFRMC. The mechanical properties, including cubic and axial compressive strengths, modulus of elasticity, splitting tensile strength, and flexural strength and toughness of the SFRMC, were analyzed, accounting for the influences of the contents of fly ash and steel fiber. The predictive formulas for the splitting tensile strength, modulus of elasticity, and flexural strength were proposed by introducing the influencing factors of steel fiber. The SFRMC showed an increased modulus of elasticity with increases in the steel fiber factor, and flexural toughness was enhanced with increased contents of both steel fiber and fly ash.
Study Regarding the Monitoring of Nocturnal Bruxism in Children and Adolescents Using Bruxoff Device
Authors: Crăciun Adriana Elena , Cerghizan Diana , Jánosi Kinga Mária , Popșor Sorin , Bica Cristina Ioana
Published: October 2023

Bruxism is a parafunctional activity represented by the gnashing and clenching of one’s teeth. The aim of this study was to determine the utility of screening and monitoring with a Bruxoff device during nocturnal bruxism in 51 children and adolescents (36 with bruxism and 15 without bruxism) by assessing the variations in the intensity and duration of parafunctional activity in each patient. Bruxoff measurements were recorded for at least 60 min for three consecutive nights for each subject. All the parameters recorded using Bruxoff in the control and the study groups showed a statistically significant difference (p < 0.05). The differences found by comparing the values recorded in the male and female study groups are significant for heart rate, the number of masseter muscle contractions during one night, and mixed contractions. The Bruxoff device proved to be important in diagnosing patients with bruxism in our practice.
Optimal Estimation of Quantum Coherence by Bell State Measurement: A Case Study
Authors: Yuan Yuan , Huang Xufeng , Niu Yueping , Gong Shangqing
Published: October 2023

Quantum coherence is the most distinguished feature of quantum mechanics. As an important resource, it is widely applied to quantum information technologies, including quantum algorithms, quantum computation, quantum key distribution, and quantum metrology, so it is important to develop tools for efficient estimation of the coherence. Bell state measurement plays an important role in quantum information processing. In particular, it can also, as a two-copy collective measurement, directly measure the quantum coherence of an unknown quantum state in the experiment, and does not need any optimization procedures, feedback, or complex mathematical calculations. In this paper, we analyze the performance of estimating quantum coherence with Bell state measurement for a qubit case from the perspective of semiparametric estimation and single-parameter estimation. The numerical results show that Bell state measurement is the optimal measurement for estimating several frequently-used coherence quantifiers, and it has been demonstrated in the perspective of the quantum limit of semiparametric estimation and Fisher information.
AI, Analytics and a New Assessment Model for Universities
Authors: Williams Peter
Published: October 2023

As the COVID-19 pandemic recedes, its legacy has been to disrupt universities across the world, most immediately in developing online adjuncts to face-to-face teaching. Behind these problems lie those of assessment, particularly traditional summative assessment, which has proved more difficult to implement. This paper models the current practice of assessment in higher education as influenced by ten factors, the most important of which are the emerging technologies of artificial intelligence (AI) and learning analytics (LA). Using this model and a SWOT analysis, the paper argues that the pressures of marketisation and demand for nontraditional and vocationally oriented provision put a premium on courses offering a more flexible and student-centred assessment. This could be facilitated through institutional strategies enabling assessment for learning: an approach that employs formative assessment supported by AI and LA, together with collaborative working in realistic contexts, to facilitate students’ development as flexible and sustainable learners. While literature in this area tends to focus on one or two aspects of technology or assessment, this paper aims to be integrative by drawing upon more comprehensive evidence to support its thesis.
Adaptive Active Inertia Control Strategy of MMC-HVDC Systems for Flexible Frequency Support
Authors: Lv Xiaojv , Wang Jialong , Zhang Zhichao , Liu Ziwen , Li Zhaoxia
Published: October 2023

The Modular Multilevel Converter High Voltage Direct Current Transmission (MMC-HVDC) technology is considered to be the most feasible choice for high-voltage and high-power transmission systems, and its flexibility and high controllability provide a new solution for renewable energy grid integration. The MMC topology contains a large number of capacitors, which enables it to provide a certain active inertia support for the connected AC system. Different from a synchronous machine, the active inertia control of an MMC can flexibly adjust a system’s inertia-supporting power by changing the control parameters. By introducing a variation of the Sigmoid function with amplitude-limiting capability, this paper proposes an adaptive active inertia control strategy for the MMC-HVDC system. The proposed scheme adjusts the inertia constant adaptively according to the frequency change rate of the AC system, which can better respond to the frequency recovery performance. Finally, the MMC-HVDC simulation model is established in PSCAD/EMTDC to verify the effectiveness of the proposed control strategy.