bluuebunny/crossref_metadata_2025 huggingface dataset:
Movimento feminista e ativismo digital: as repressões online e offline a partir do uso das plataformas digitais pelo movimento
Authors: Mendonça Fernanda , Langner Ariane , Zuliani Cibeli
Published: July 2023

ResumoA internet tem sido vista como uma grande oportunidade de expansão e de divulgação das ações de movimentos sociais. Neste sentido, o trabalho tem como objetivo verificar se é possível afirmar que essa apropriação da internet pelo feminismo vem trazendo repressões e censuras que antes não ocorriam - realizando o contraponto ao entendimento de que a internet só traz benefícios pela facilidade no compartilhamento de informações. Palavras-chave: Feminismo. Ativismo Digital. Novas Tecnologias de Comunicação e Informação. Internet. Repressão.Abstract The internet has been seen as a great opportunity for expansion and dissemination of the actions of social movements. The study aims to see if it can be said that this appropriation of the internet by the feminism has brought repression and censorship that did not occur - doing the counterpoint to the current understanding that the internet only brings benefits because of easy sharing information. Keywords: Feminism. Digital Activism. Internet. New Technologies of Information and Communication. Repression.Â
Desobediências de gênero e pensamentos-cupim a partir das músicas de Linn da Quebrada, Alice Guél e Ventura Profana
Authors: Kleizer Hígor , Vannuchi Maria Lúcia
Published: July 2023

Este artigo aborda as formas como desobediências de gênero são mobilizadas nas músicas de Linn da Quebrada, Alice Guél e Ventura Profana para pensá-las em suas potencialidades de “pensamentos-cupim”, isto é, provocações contradiscursivas que tensionam a pretensa coerência do regime sexo-gênero-desejo e os lugares possíveis às suas dissidências.

PALAVRAS-CHAVE: Desobediências de Gênero. Músicas Brasileiras. Pensamentos-Cupim.
Dysphoria mundi: por uma nova ontologia política comum
Authors: Axt Bryan
Published: July 2023

PRECIADO, P. B. Dysphoria mundi. El sonido del mundo derrumbándose. 560 p. Espanha: Editorial Anagrama, 2022.
Efficacy and safety of a daytime anxiolytic containing technologically processed antibodies to the S100 protein. Overview of clinical studies
Authors: Perez M. , Zavadenko N. N. , Skipetrova L. A. , Smirnov I. I. , Nesterovskiy Yu. E.
Published: July 2023

The review presents the results of clinical studies of the efficacy and safety of Tenoten and Tenoten children’s in the treatment of anxiety, neurotic, stress-related and somatoform disorders and adjustment disorders. Technologically processed antibodies to the S100 protein in Tenoten and Tenoten children’s drugs change the conformation of the S100 protein, which is considered as a pathological link in the development of anxiety states, as well as neurodegenerative diseases. Tenoten is a well-studied daytime anxiolytic that combines a favorable safety profile with high anxiolytic activity. The efficacy of Tenoten in the treatment of anxiety disorders is comparable to that of benzodiazepine drugs. Tenoten has no inhibitory and muscle relaxant effects, does not cause drug tolerance, addiction, "withdrawal" syndrome, as well as drug interactions. Tenoten for children has been shown to be effective in the treatment of anxiety in children, including those with somatic manifestations, attention deficit hyperactivity disorder, and learning disabilities.
Vitamin B12 deficiency and Parkinson’s disease
Authors: Zalyalova Z. A. , Ekusheva E. V.
Published: July 2023

Parkinson’s disease (PD) is a progressive neurodegenerative disease with various clinical manifestations, its origin not always can be explained only by dopamine deficiency. Long-term treatment with levodopa (especially its intraduodenal administration), as well as clinical manifestations of polyneuropathy, cognitive deficits, postural disorders with freezing of gate, REM sleep behavioral disorders, are more often associated with vitamin B12 deficiency. Several reasons for this association and mechanisms of their development are discussed. Early detection of cobalamin deficiency in PD, especially in patients from high-risk groups, makes it possible to stop this pathological condition timely and prevent irreversible changes. Modern data on the use of high-dose (1000 μ g) oral vitamin B12 are presented, it has comparable clinical efficacy and significant advantages, compared with the parenteral form, in terms of the ease of use and the ability to avoid undesirable postinjection reactions.
Safety and tolerability of repetitive transcranial magnetic stimulation: an analysis of over 1200 sessions
Authors: Bakulin I. S. , Zabirova A. Kh. , Poydasheva A. G. , Lagoda D. Yu. , Suponeva N. A. , Piradov M. A.
Published: July 2023

Transcranial magnetic stimulation (TMS) is increasingly used in research and clinical practice, therefore, the issues of its safety and tolerability are especially important. Currently, serious adverse reactions (ARs) are extremely rare. The more common mild ARs that can develop during and after stimulation remain less well understood but may affect procedure tolerance and treatment adherence.

Objective: to study the tolerability and safety of TMS in patients and healthy volunteers.

Material and methods. In a retrospective cohort study using standardized questionnaires, ARs were assessed during and within 24 hours after TMS in patients (n=103) and healthy volunteers (n=74).

Results. In total, the data of 1246 sessions were analyzed. ARs were observed during 56.8% of the analyzed sessions and within 24 hours after in 21.5% of the sessions. In most cases, they were mild and did not affect the intent to continue stimulation. TMS withdrawal due to ARs was reported in six cases (3.3% of participants), three of which experienced severe headache (HA) after stimulation. During stimulation, sleepiness (32.4%) and pain in the stimulation area (20.3%) were most often recorded. The most frequent AR within 24 hours after TMS was HA (13.3% of sessions), its characteristics are described and possible diagnostic criteria are proposed.

Conclusion. ARs can occur during and after a TMS session and are mild in most cases. TMS-induced HA, which is the most common AR within 24 hours after TMS, can be considered a distinct type of secondary HA, the pathogenesis of which requires further study.
Inflammatory biomarkers and growth factors in patients with chronic cerebrovascular disease after coronavirus infection
Authors: Kuznetsova E. B. , Voskresenskaya O. N. , Zakharova N. B. , Kuznetsov N. S.
Published: July 2023

Objective: to study the level of inflammatory biomarkers and growth factors in the peripheral blood of patients with chronic cerebrovascular disease (CCVD) and anamnesis of coronavirus infection COVID-19.

Material and methods. The study included patients with CCVD (n=41), 26 of them had a documented anamnesis of coronavirus infection within 4 months before inclusion in the study, 15 people did not have COVID-19. The control group consisted of 20 apparently healthy individuals of the same age. Neuroimaging was performed using a Philips Achieva 1.5 T device. Pro-inflammatory cytokines were determined in blood serum – tumor necrosis factor α (TNF α ), interleukin 6 (IL6), IL18, interferon γ (IFN γ ); chemokines – monocytic chemoattractant protein 1 (MCP-1), IL8; growth factors – vascular endothelial growth factor type A (VEGF-A), transforming growth factor β 1 (TGF β 1).

Results. In patients with CCVD, compared with the control group, an increase in the level of proinflammatory cytokines (TNF α , IL6, IL18), chemokines (MCP1 and IL8), a decrease in the concentration of IFN γ , and divergent changes in the content of growth factors (VEGF-A and TGF β 1) were noted. Patients who recovered from COVID-19 showed an increase in the level of IL6 and a decrease in the level of IFN γ compared with those who had not been ill, which indicates a persistently high activity of immunoinflammatory processes and an insufficient humoral immune response.

Conclusion. Postponed coronavirus infection COVID-19 aggravates the existing endothelial dysfunction and intravascular inflammation in patients with CCVD, which may probably require changes in their treatment and prevention strategies in the future.
Prediction of restoration of swallowing function in patients with ischemic stroke and neurogenic dysphagia
Authors: Borzdyko A. A. , Ershov V. I. , Gumalatova N. V. , Lozinskaya T. Yu. , Lutsai E. D.
Published: July 2023

Objective: to determine prognostic characteristics of the restoration of swallowing function in patients with ischemic stroke (IS) of various pathogenetic subtypes.

Material and methods. The study included 110 patients (64 men and 46 women aged 44–89 years) with dysphagia in the acute period of IS. The SSS-TOAST criteria were used to diagnose the pathogenetic subtype, and the MASA scale was used to determine the presence and severity of dysphagia. To predict the probability of switching to self-feeding depending on the severity of dysphagia, a non-linear regression method was used using the least squares method.

Results. Patients with cardioembolic stroke subtype were initially characterized by a greater degree of dysphagia in comparison with patients with atherothrombotic stroke subtype in groups comparable in severity (p<0.05). In the cardioembolic subtype of IS, the probability of switching patients to self-feeding on the 21st day in groups with dysphagia severity from 105 to 135 points on the MASA scale was lower than in the atherothrombotic subtype of IS (p<0.05).

Conclusion. Patients with cardioembolic strokes are characterized by more severe initial dysphagia and a worse prognosis for recovery of swallowing function compared to patients with atherothrombotic strokes.
Clinical effectiveness and safety of prolonged release form of alimemazine in patients with generalized anxiety disorder
Authors: Azimova Ju. E. , Sivolap Yu. P. , Ishchenko K. A.
Published: July 2023

The prolonged release tablets form of alimemazine is seen as a promising agent for the long-term treatment of generalized anxiety disorder (GAD).

Objective: to investigate the efficacy and safety of therapy with alimemazine (Teraligen® retard, prolonged release film-coated tablets) in patients with GAD.

Material and methods. The study design was a multicentre, open-label, non-comparative clinical trial (CT) with two doses of alimemazine 20 and 40 mg (Teraligen® retard, prolonged-release film-coated tablets). 129 patients diagnosed with GAD (criteria according to the ICD-10 classification), 86 women and 43 men were included, mean age 38.0±11.1 years. The level of anxiety, assessed by the Hamilton HARS scale, at Week 0 (Visit 1) was 24.8±7.3 points.

Results. By Week 6, the level of anxiety statistically significantly decreased to a mean score of 10.8±6.6, while the dynamics of the mean score relative to baseline was -14.0±6.27 (p<0.0001). The proportion of patients with a decrease in the total score on the HARS scale by 50% or more compared with the initial value was: after 1 week of therapy – 10.3% (n=13); after 3 weeks of therapy – 60.5% (n=75; compared to baseline, p<0.0001); after 6 weeks of therapy – 69.4% (n=86; compared to baseline, p<0.0001). The therapy was well tolerated, among the adverse events (AEs) patients noted: morning sleepiness (7.8%; n=10); dry mouth (7.8%; n=10); general weakness (4.7%; n=6). Other AEs (dizziness, headache, impaired concentration, muscle weakness, memory impairment, tinnitus, tachycardia) were much less common. From the side of the liver, no AEs were detected, including changes in the activity of liver enzymes.

Conclusion. Prolonged release alimemazine tablets 20 mg and 40 mg for six weeks resulted in a statistically significant reduction in anxiety levels, with at least two-thirds of patients experiencing more than half their anxiety. The effect increases with each week as you continue to take the drug. The prolonged release form of alimemazine is well tolerated, the treatment of GAD with the drug is effective and safe and may represent a rational alternative to antidepressant therapy.
Monozygotic twins with concordant female-to-male gender dysphoria with different temperament characteristics: a case report
Authors: Bidaki R. , Salimi Z. , Naderi Deh Ghotbadini R. , Amiri Gavar S. , Dehghani F.
Published: July 2023

Gender Dysphoria (GD) is defined as a marked incongruence between one’s experienced/expressed gender and assigned gender that the individual feels a strong desire for having the sex characteristics of the other gender. Twin studies could be helpful in making decisive conclusion on the relative role of genetics and environment on GD. Therefore, we hereby present a case of monozygotic twins with concordant female-to-male GD. Seventeen-year-old twins are introduced in this case report. The second pair attended to our clinic for psychiatric evaluation. She was suffering from GD by overwhelmed desire for having masculine features, wearing their cloths, and at the same time revolting being a girl. Although she preferred spending time with male friends, she was sexually attracted to females. Although the first pair had similar characteristics of GD, she presented apposite temperament. While temperament has been considered to be genetically inherited, the incidence of GD in our cases with different temperaments raises the question about genetic role in inheriting temperament and GD. Further twin studies will help understanding the extent of genetic influence on these features.
Mental disorders during the pandemic of a new coronavirus infection: clinical features
Authors: Vysokova V. A. , Tyuvina N. A. , Maksimova T. N. , Prokhorova S. V.
Published: July 2023

Objective: to study the clinical features of mental disorders during the COVID-19 epidemic in those who turned to psychiatrist for the first time, as well as in patients with already diagnosed mental illness.

Material and methods. We examined 100 patients who turned to psychiatrist due to deterioration of their mental state on the background of a pandemic. Of these, 50 were new cases (1st group; 23 women and 27 men, mean age 34 years) and 50 were cases with previously diagnosed mental disorders (2nd group; 25 women and 25 men, mean age 37 years). 80% of patients of the 1st group, 54% of patients of the 2nd group had coronavirus infection. Anxiety and depressive disorders prevailed in the 1st group, endogenous diseases prevailed in the 2nd group: bipolar affective disorder, recurrent depressive disorder, schizophrenia. The study was conducted by the clinical method using a specially designed map; the severity of depression was assessed using the Montgomery-Asberg Depression Rating Scale, and the severity of anxiety was assessed using the Hamilton Anxiety Rating Scale.

Results. The clinical picture of primary and recurrent depressive episodes after infection was characterized by the presence of motor and associative retardation, severe apathy, hypersomnia and lack of sleep, fatigue, increased appetite, and complaints of impaired attention and memory. Depression in SARS-CoV-2 survivors was characterized by anxiety, anhedonia, irritability, somatic complaints, and hypochondriacal inclusions. Anxiety symptoms in those who were not ill included severe anxiety, reaching agitation, disturbed sleep with frequent awakenings, irritability, somatic complaints, and hypochondriacal fixation on one’s condition. In recovering patients, anxiety was accompanied by control of somatic functions, cognitive impairments, and fear of retention or even intensification.

Conclusion. The results obtained indicate the existing differences between the mental disorders that first appeared and worsened during the pandemic, as well as the differences in the structure of the depressive and anxiety syndrome depending on the presence or absence of coronavirus infection.
Promoting Exclusive Breastfeeding in Sokoto: The Role of Counseling, Parental Support, and Health Education
Authors: Musa Shamsuddin , Sarkingobir Yusuf , AI Umar , Abubakar Abdullahi Mukhtar
Published: July 2023

Purpose – This study aims to investigate exclusive breastfeeding (EBF) in Sokoto.
Design/methods/approach – A survey type of 300 respondents was used; data were analyzed with frequency counts/percentages and an X2 test.
Findings – All respondents were female (100.0%), aged 26-35 (100.0%). The majority of the participants were single (66.7%) and unemployed (66.7%), with a secondary school education (66.7%). However, 33.3% of the participants were married, were civil servants, and had tertiary education. The study revealed that the majority (66.7%) had received breastfeeding counseling during antenatal care. All respondents (100.0%) received proper guidance/counseling at home on exclusive breastfeeding. Fathers (66.7%) and mothers (33.3%) supported exclusive breastfeeding. The respondents reported exclusively breastfeeding their child for the first six months after delivery (100.0%), and weaning occurred between 19-24 months. The reasons for avoiding exclusive breastfeeding were the sickness of the mother (66.7%) and insufficient milk (33.3%). All respondents (100.0%) agreed that exclusive breastfeeding improved the baby’s health, and health awareness encourages breastfeeding (100.0%).
Research implications/limitations – This study provides a limit in the form of maximum exclusive breastfeeding for children aged 24 months.
Practical implications – The study suggests that counseling, support from parents, and health awareness can improve exclusive breastfeeding, and healthcare providers should provide such services during antenatal care while promoting the practice through health education campaigns.
Originality/value – This study highlights the importance of counseling, parental support, and health education in promoting exclusive breastfeeding and improving the health of infants in Sokoto.
Paper type Research paper
Die Wirtschaft Polens in der Krisenlage, unter besonderer Berücksichtigung der räumlichen Aspekte
Authors: Potrykowski Marek
Published: July 2023

In der Nachkriegszeit erlebte Polen zu wiederholten Malen wirtschaftliche Schwierigkeiten. Der letzte Zusammenbruch der Wirtschaft ist aber tiefgehender und umfassender als die früheren. Darüber hinaus ist er in hohem Maße räumlich bedingt, obwohl die Ursachen und Folgen der Krise eher in den Schwächen der sektoralen Wirtschaftsstrukturen zu sehen sind. Das Organisationsmodell der Wirtschaft Polens wurde durch einen hohen Zentralisierungsgrad und Dominanz des staatlichen Sektors gekennzeichnet. Die Rolle der Raumplanung war für die Raumgestaltung unbedeutend. Zur Zeit hat Polen eine große Chance, dieses Modell radikal zu ändern. Die Richtungen der Wirtschaftsumgestaltung enthält das Programm der neuen Regierung (Schaffung neuer Eigentumsverhältnisse, Einführung der Marktmechanismen, Umgestaltung des Finanzsystems). Die Verwirklichung dieses Programms erfordert Unterstützung von außen, denn die polnische Wirtschaft muß sich zum Weltmarkt öffnen.
Die Belange der Landschaftspflege und des Naturschutzes im Raumordnungsverfahren
Authors: Strunz Joachim
Published: July 2023

In dem nachstehenden Beitrag wird die These vertreten, daß die Meßgenauigkeit, mit der die Belange des Naturschutzes und der Landschaftspflege im Raumordnungsverfahren von den Fachstellen des Naturschutzes erfaßt werden, verbessert werden sollte. Um genauer messen zu können, bedarf es in diesem Fachbereich genauerer Maßstäbe.Um dieses Ziel zu erreichen, sollten Ansätze im Fachbereich Naturschutz, regionale Leitbilder auszuarbeiten, weiterentwickelt werden. Mehr differenzieren und mehr quantifizieren ist das Verhaltensgebot für diesen Fachbereich.Es ist einfach nicht gut, wenn allgemeine Ziele des Naturschutzes innerhalb eines Raumordnungsverfahrens erst konkretisiert werden müssen. Es ist viel besser, wenn ein möglichst konkretes naturschützerisches Zielsystem mit Prioritäten bereits vorliegt. Ein solches Zielsystem hätte überdies den hoch einzuschätzenden Vorteil, daß naturschützerische Äußerungen von Außenstehenden leichter nachvollziehbar wären und damit auch auf mehr Verständnis und mehr Akzeptanz stießen.
Siedlungsstrukturforschung und -planung auf dem Gebiet der DDR
Authors: Scherf Konrad
Published: July 2023

Zunächst werden Ergebnisse der Siedlungsstrukturforschung und -planung unter den bisherigen gesellschaftlichen und Planungsbedingungen in der DDR dargestellt. Dabei werden Beziehungen zu Strukturveränderungen auf dem Lande, zur politisch-administrativen Territorialgliederung sowie zu räumlichen Konzentrations- und Umverteilungsprozessen innerhalb der Siedlungsstruktur untersucht. Theoretische und methodische Ausführungen zur Siedlungsstrukturplanung beziehen sich auf die Anwendung des Zentrale-Orte-Prinzips, auf die Trennung von Stadt- und Gebietsplanung, auf Siedlungsnetzkonzeptionen auf regionaler Ebene, Siedlungskategorien und Stufen der infrastrukturellen Ausstattung sowie auf systemtheoretische Forschungs- und Planungsansätze.Ausgehend von den sich seit Herbst 1989 vollziehenden grundsätzlichen gesellschaftlichen Veränderungen werden Gedanken über die künftige Siedlungsstrukturentwicklung, -planung und -forschung geäußert. Dabei werden Bezüge zur Marktwirtschaft und kommunalen Selbstverwaltung sowie zur Verwaltungsund Gebietsreform hergestellt. Der Analyse und Bestimmung zentraler Orte und ihrer Verflechtungsbereiche (Einzugsgebiete), der Untersuchung der Siedlungsstruktur in agglomerierten Räumen und Gebieten tiefgreifenden Strukturwandels wird besondere Aufmerksamkeit geschenkt. Abschließend wird für eine enge Verbindung von Raumordnung, Stadt- und Regionalplanung durch die Schaffung einer integrierten Gebietsplanung plädiert.
Bewertungsgrundlagen für die Raum- und Umweltplanung durch Umweltinformationssysteme
Authors: Du Bois Wolfgang
Published: July 2023

Zur Erhöhung der Effizienz des Umweltschutzes in öffentlichen Verwaltungen müssen verstärkt DV-gestützte Umweltinformationssysteme eingesetzt werden. Die Komplexität der Vorgänge in der Umwelt und die Folgen der menschlichen Eingriffe können nicht ausreichend sachgerecht mit “Papier und Bleistift" abgeschätzt werden.Am Beispiel des Umweltinformationssystems UMWISS des Umlandverbands Frankfurt (UVF) (1) wird dargestellt, wie sich Bewertungsgrundlagen für die Raum- und Umweltplanung verbessern lassen, welche grundsätzlichen Überlegungen beim Aufbau solcher Systeme zu berücksichtigen sind und welche allgemeinen System-Strukturen zu beachten sind. An den sektoralen Bereichen Lärmminderung, Liftreinhaltung und Bodenschutz werden die Wirkungsweisen und Arbeitsergebnisse erläutert.
Raumordnung und Recht
Authors: Goppel Konrad
Published: July 2023

Die Raumordnung zeigt naheliegende Affinitäten zu einer Reihe von Fachbereichen. Vom fachlichen Selbstverständnis und Instrumentarium aus gesehen zum Städtebau, von der historischen Aufgabenstellung her betrachtet zur Wirtschaft, nach moderner gesellschaftlicher Gewichtung zur Ökologie und unter ästhetischen Aspekten zur Harmonie- und Gestaltungsidee des Landschaftsgartens im 18. Jahrhundert. Eine umstrittene Beziehung der Raumordnung ist die zum Recht. Das Schlagwort der "Verrechtlichung" der Raumordnung ist nicht zu akzeptieren. Die Verbindung der Raumordnung als staatliche Aufgabenstellung mit dem Recht ist notwendig und keineswegs außergewöhnlich. Dies gilt besonders für eine Aufgabenstellung, die gezwungen ist, als neutraler Mittler staatliche Fachbelange gegeneinander abzuwägen und damit im Einzelfall auch bei der Abwägung unterliegen zu lassen.Die Verbindung mit dem Recht ist freilich nicht problemlos, soweit sich die Raumordnung zur Durchsetzung ihrer generellen Festlegungen in Form der Ziele verbindlicher Normen bedient. Naturgemäß muß einer von Unwägbarkeiten der Zukunft abhängigen und damit flexiblen Planung die Einbindung in notwendigerweise starre, auf verläßlichen Bestand ausgerichtete Rechtsnormen widerstreben. Der systembedingte Konflikt ist über den Zwang zur ständigen Überprüfung und Fortschreibung zu mildern, aber nicht völlig aufzulösen.Die notwendige Verbindung von Raumordnung und Recht wird durch die These überhöht, daß die Ordnung des Raumes sogar als Wurzel des Rechts schlechthin betrachtet werden kann. Dies gilt sowohl für die historische Entwicklung des Rechts aus der Ordnung und Gliederung des Raumes als auch für die sprachgeschichtliche Ableitung des griechischen Nomos (Gesetz) von nemein, das nicht nur "Weiden", sondern auch das "Gerechte Verteilen" von Weideland, also von Raum und Fläche bedeutet.
Wohnkosten, Haushaltsvermögen und Förderungseffizienz
Authors: Deutsch Edwin , Schöpp Wolfgang
Published: July 2023

Die vorliegende Studie legt theoretische Überlegungen und emprisches Material zum Thema der Finanzierungskraft der Haushalte im Wohnwesen vor. Der Begriff der Finanzierungskraft umfaßt die Lebenszykluseinkommen, die ererbte bzw. übertragene Vermögensausstattung sowie komplementäre Vermögensbestandteile wie die Kreditwürdigkeit durch Ausbildung und Beruf, und auch intangible Komponenten wie die Zugehörigkeit zu bestimmten Schichten mit unterschiedlicher Information über den Zugang zum Wohnungsmarkt. Es wird argumentiert, daß in einer Welt mit unterschiedlichen Vermögensausstattungen stets die Tendenz besteht, daß die Wohnungsanbieter die Haushalte mit Vermögensvorteilen an sich binden. Das soziale Problem des Wohnens wird darin erblickt, daß Haushalte ohne ausreichende Vermögensausstattung sowohl im Rahmen einer freien Wohnungsmarktwirtschaft als auch, aufgrund ökonomischer und sozialer Ineffizienzen, bei ausgeprägter angebotsseitiger Staatsintervention vom Wohnungsmarkt ausgeschlossen werden. Es wird vorgeschlagen, ein Subjekthilfe System nach dem Muster einer negativen Einkommensteuer zu implementieren, während geeignete Anreize benötigt werden, daß eine Vielfalt von Angebotstypen die langfristige Wohnraumversorgung für aufeinanderfolgende Generationen sicherstellt. Zum Beleg dient ausführliches Material über die Wohnsituation in Österreich.
Altlastenproblematik im Rahmen der Bauleitplanung
Authors: Schröter Frank
Published: July 2023

Wird der Begriff Altlasten im Rahmen der Bauleitplanung benutzt, so darf er nicht mit den Bodenbelastungen, die üblicherweise unter diesem Begriff summiert werden, gleichgesetzt werden. Altlasten im Rahmen der Bauleitplanung sind nahezu sämtliche Bodenbelastungen, von denen möglicherweise eine Beeinträchtigung der Umwelt zu erwarten ist. Die im Baugesetzbuch enthaltene Verpflichtung, “erheblich mit umweltgefährdenden Stoffen belastete Böden” zu kennzeichnen, läßt eine Reihe von Fragen offen. Einflußfaktoren auf die Erheblichkeitsschwelle, eine Liste umweltgefährdender Stoffe und die Planzeichen der Kennzeichnung in Bebauungsplänen müssen bundeseinheitlich definiert und angewandt werden.Die Erheblichkeitsschwelle, bei deren Überschreitung eine Altlast im Bauleitplan gekennzeichnet werden muß, ist neben der Toxizität noch von mehreren anderen Faktoren abhängig. Generell sollte sie jedoch im Bereich des vorbeugenden Schutzes angesiedelt werden. Die Inhalte der zeichnerischen Kennzeichnung sollten über die bloße Hinweisfunktion hinausgehen und z.B. auch Nutzungseinschränkungen und Ursachen der Bodenbelastung beinhalten.Der vorliegende Beitrag erläutert wesentliche Einflußfaktoren auf die Kennzeichnung und stellt Definitionsansätze zur Diskussion.
Modernisierung der Fertigung, das dominante Instrument der einzelbetrieblichen Technologieförderung in Baden-Württemberg
Authors: Hahn Roland , Gaiser Arne
Published: July 2023

Dominantes einzelbetriebliches Wirtschaftsförderkonzept des Landes Baden-Württemberg ist das Modernisierungsprogramm. Sowohl innovierende Unternehmen der Wachstumsbranchen und der traditionellen Branchen als auch Unternehmen in Agglomerationsräumen und in ländlichen Räumen wurden gefördert. Unterschiede zwischen Stadt- und Landkreisen ergeben sich hinsichtlich der durchschnittlichen Mittelzuweisungen je Unternehmen und der Bewilligungsdichten.
Nichtadministrative Gebietsgliederungen und -kategorien für die Regionalstatistik
Authors: Görmar Wilfried , Irmen Eleonore
Published: July 2023

Gebietsgliederungen und -typisierungen sind für die räumliche Planung, Forschung und Politik eine wichtige Arbeitsgrundlage. Sie dienen der Erfassung und Beobachtung wesentlicher räumlicher Zusammenhänge und Entwicklungen. Die Raumbeobachtung als ein Instrument der Politikberatung ist auf geeignete nichtadministrative räumliche Bezugssysteme angewiesen. Neben fachpolitischen und -wissenschaftlichen Regionsabgrenzungen und -typisierungen sind dabei stets auch räumliche Bezugssysteme gefragt, die für komplexere Fragestellungen und Entwicklungsprozesse einen vergleichbaren und leicht handhabbaren Rahmen bilden können. Die siedlungsstrukturelle Gebietstypisierung der Bundesforschungsanstalt für Landeskunde und Raumordnung (BfLR) ist in diesem Sinne angelegt und hat sich in den alten Ländern für die Zwecke der Raumbeobachtung bewährt. Eine Modifizierung und Erweiterung unter Berücksichtigung der spezifischen Situation und Entwicklung in den neuen Ländern wird in diesem Beitrag näher vorgestellt.
Leitlinien und Leitbilder für eine ökologisch orientierte Regionalplanung
Authors: Schmidt Albert
Published: July 2023

In dem Beitrag wird eingangs das Planungssystem von Landes- und Regionalplanung in der Bundesrepublik Deutschland erläutert und werden ökologische Planinhalte bzw. deren rechtliche Grundlagen anhand nordrhein-westfälischer Beispiele dargestellt. Als Konsequenz aus den wachsenden Ansprüchen an den Freiraum wird eine stärker ökologisch orientierte Regionalplanung gefordert, die geeignet sein muß, neben den traditionellen Koordinierungs- und Abstimmungsfunktionen auch eine Mittlerfunktion bei Konflikten zwischen Ökologie und Ökonomie zu erfüllen. Um dieses Ziel zu erreichen, wird vorgeschlagen, daß Landes- und Regionalplanung ihre raumbedeutsamen Ziele und Erfordernisse aus einem landesweiten Landschaftsprogramm und eigenständigen Landschaftsrahmenplänen als umfassende Fachkonzepte für Natur und Landschaft ableiten. Für Nordrhein-Westfalen bietet die inhaltliche Grundlage dafür das neue naturschutzpolitische Programm "Natur 2000 in NRW”. Die möglichst umfassende Integration landschaftsrahmenplanerischer Zielvorstellungen in den Regionalplan setzt voraus, daß der Landschaftsrahmenplan umsetzungsorientiert konzipiert wird und sich sein Inhalt möglichst auf räumlich präzise darstellbare Planungsziele beschränkt.
Open Government Data in Pandemic Disease: Encouraging Spatial Policy-Making in East Java and Jakarta
Authors: Imawan Arga Pribadi , Fathurrahman Rifqi
Published: July 2023

This article aims to elaborate on whether the openness of spatial data by the government has an implication for the formulation of government policies. The case was taken in two provinces, namely the East Java provincial and the Special Capital Region (DKI) Jakarta. The case study method was conducted by referring to a database of documents, journals, news and books relating to the spatial data visualization and provincial government policies. ArcGis application is also used as one method of presenting data. As a result of the elaboration by using the concept of models open government data (OGD) and spatial policy-making, this article discovers facts that models of OGD in East Java are at the four-stage which is data integration between government and social data. However, DKI Jakarta shows the stage of OGD models is in integration government data stage. Both provincial showed that the policy-formulation for Covid-19 are not based on spatial data. Therefore, it can be assumed policy for handling Covid-19 is not effective. Both of provinces shows continually increasing cases of Covid-19 positive patients. These two provinces are predicated as the highest level of Covid-19 cases in Indonesia. From a practical point of view, Indonesia needs to implementing spatial data-based policies to break the Covid-19 chain, as this kind of policy orientation has been successfully implemented by Taiwan which has been successful tackling Covid-19.
Type 1 diabetes management in a competitive athlete: A five‐year case report
Authors: Cannataro Roberto , Cione Erika , Cerullo Giuseppe , Rondanelli Mariangela , Micheletti Piero , Crisafulli Oscar , Micheli Matteo Levi , D'Antona Giuseppe
Published: July 2023

Type I diabetes has an incidence of 15 per 100,000 people. Though it is a metabolic disorder, it can be seen in top, even professional athletes. Physical activity is recommended to manage diabetes, but there is a lack of specific knowledge on diabetes management and exercise from dedicated medical staff. This bias leads to suboptimal diabetes management, causing frequent hyper and hypoglycemia, a dysregulation of glycated hemoglobin, blood glucose out of control, and consequent needs to often intervene with extra insulin or carbohydrates. For 5 years, we followed a highly competitive male Caucasian athlete Vovinam Viet Vo Dao, with type I diabetes, aged 17. We monitored his glycated hemoglobin, the insulin drug administered, and glycemia blood level averages. We obtained, over time, a decrease in glycated hemoglobin by almost −22% and insulin administered by −37.33%, and average blood glycemia levels diminished by almost −27%. In addition, we carried out bioimpedance analysis and stratigraphy on the abdomen. Federation trainers supervised all physical training; we recorded an improvement in the general condition, underlined in particular by an increase in phase angle (from bioimpedance) of +17%.
Using STEAM and Bio-Inspired Design to Teach the Entrepreneurial Mindset to Engineers
Authors: Bosman Lisa , Shirey Katherine L.
Published: July 2023

The need for addressing global and societal problems is stronger than ever, as demonstrated by the UN Sustainable Development Goals and National Academy of Engineering Grand Challenges. However, engineering undergraduate students rarely get to experience engaging with the associated real-world projects and challenges. This has the potential to result in attenuation from engineering education and career pathways. This study aimed to overcome this issue by reaching the United States’ untapped future engineering workforce via an engineering educator professional development “train-the-trainer” program. This train-the-trainer program guided engineering educators to apply evidence-based pedagogical methods (e.g., backward course design) to couple entrepreneurial mindset (EM) development with STEAM (science, technology, engineering, arts, math) and bio-inspired design in an effort to improve the retention of underrepresented engineering students via a transdisciplinary, humanistic approach. This study employed a mixed methods approach including retrospective post-then-pre items based on perceived learning gains, rating the overall satisfaction with the program, and open-ended questions to better understand what went well, what did not go so well, and what can be improved. From a practical perspective, this study shows that integrating STEAM (with a specific focus on the arts) into the engineering classroom promotes problem-solving and critical thinking across disciplines. Here, applying STEAM principles encourages diverse perspective taking and making by bridging paradigms and theoretical frameworks across a variety of humanities and technical disciplines. As a result, combining STEAM with bio-inspired design and the EM has the capacity to increase engagement and broaden participation among students traditionally underrepresented in engineering, including females and minoritized populations.
Mnemonic ‘Boundary Objects’ and Postcolonial Restitution
Authors: Zolkos Magdalena
Published: July 2023

Drawing on new materialist and object-centered historical criticism, this article analyses colonial and post-colonial discourses of the Greenlandic figurines of the mythical being of ill-wishing and revenge, tupilak (plural form: tupilait). It focuses on three tupilak figures, made in 1905/1906 by a shaman Mitsivarniannga on a request of a Danish ethnographer William Thalbitzer, which today are part of the Danish National Museum collections. In the early 20th century, Greenlandic tupilait (and Inuit cultural production in general) were an object of fascination among European collectors, artists, and the general public. Asking what these objects had come to mean in (and for) Europe, this article points to marginalized Greenlandic narratives of Mitsivarniannga’s tupilat, and builds a critical narrative of these objects as material effects of the disruptions of indigenous community and sustenance by Western colonialism. Drawing on critical insights from the current post-colonial restitution debates, it problematizes the differential political-economic conditions and relations of power, under which the colonial acquisitions and procurements took place. The article argues that cultural heritage items, such as the three tupilat, are mnemonic ‘boundary objects’ that can potentially forge links between disparate memories of colonialism in Denmark and Greenland.
How I live [participate] now: Re-negotiating social belonging and linguistic participation in book-group discussions
Authors: Granqvist Angelica
Published: July 2023

This paper focuses on how Gabriella, an upper-secondary student in Sweden, re-negotiated social belonging and linguistic participation in book-group discussions involving students in the school subjects Swedish and Swedish as a second language. Gabriella immigrated to Sweden due to forced migration. As a Swedish language learner, she worried that her language proficiency was regarded as insufficient by her peers. Within the frame of linguistic ethnography, and with the aim of identifying Gabriella’s trajectory of participation in book-group discussions over time, audio-recorded group discussions about the novel How I live now, interview data, and observational fieldnotes were analyzed by means of an epistemic stance analysis. Building on learning as participation, it was possible to unfold how Gabriella went from a passing participant to a driving force. Her trajectory of participation was spurred by the content of the novel and a sense of epistemic responsibility to share her first-hand experience of war, while her classmates responded with silence. From an educational perspective, this paper emphasizes the importance of classrooms as contact zones where students are not only provided with rich opportunities to gather around literature that stirs up questions of what it means to be human, but more importantly, it accentuates the need for literary education to include responsive practices to help students accommodate each other as co-learners.
A novel approach to enhancing the Klobuchar algorithm to mitigate the effect of ionospheric delay errors on static single-frequency receivers
Authors: Elshambaky Hossam Talaat
Published: July 2023

The demand for real-time high-precision positioning for global navigation satellite system applications is difficult to satisfy. In this regard, a single-frequency receiver is found to play an important role in overcoming this challenge, especially in developing countries where economic factors are a major restriction. Hence, the development of built-in models, such as the Klobuchar model, is an important objective for single-frequency users to mitigate the effect of ionospheric delay errors in real-time applications. Accordingly, this study aims to devise a new approach to enhance the behavior of the Klobuchar model and increase its efficiency in resolving the aforementioned problem. The new approach seeks to enhance the behavior of the Klobuchar model without refining or increasing its coefficients. To eliminate the ionospheric delay disturbance, the proposed methodology applies normalization and filtration processes to the raw ionospheric delay probability distribution estimated by the unified least squares technique. A final assessment of the new method for enhancing the Klobuchar behavior in predicting the precise position of a single-frequency static receiver under different weather conditions around the globe is presented in this paper.
Crushing performance and optimization of bio-inspired multi-cell columns
Authors: Öztürk İsmail
Published: July 2023

Multi-cell columns inspired by diatom algae have been examined regarding crashworthiness. Crushing simulations have been conducted for AA2024-T351, B1500HS-O25, and a combination of these materials. The highest specific energy absorption and lowest peak crushing force value were obtained with a homogenous AA2024-T351 column. Single and multi-objective optimization studies have been conducted with this column to find the best design. This design could be used in crash-box-like structures in automotive design.
A multi-strategy boosted prairie dog optimization algorithm for global optimization of heat exchangers
Authors: Gürses Dildar , Mehta Pranav , Sait Sadiq M. , Kumar Sumit , Yildiz Ali Riza
Published: July 2023

In this article, a new prairie dog optimization algorithm (PDOA) is analyzed to realize the optimum economic design of three well-known heat exchangers. These heat exchangers found numerous applications in industries and are an imperative part of entire thermal systems. Optimization of these heat exchangers includes knowledge of thermo-hydraulic designs, design parameters and critical constraints. Moreover, the cost factor is always a challenging task to optimize. Accordingly, total cost optimization, including initial and maintenance, has been achieved using multi strategy enhanced PDOA combining PDOA with Gaussian mutation and chaotic local search (MSPDOA). Shell and tube, fin-tube and plate-fin heat exchangers are a special class of heat exchangers that are utilized in many thermal heat recovery applications. Furthermore, numerical evidences are accomplished to confirm the prominence of the MSPDOA in terms of the statistical results. The obtained results were also compared with the algorithms in the literature. The comparison revealed the best performance of the MSPDOA compared to the rest of the algorithm. The article further suggests the adaptability of MSPDOA for various real-world engineering optimization cases.
BCL2L13 protein prevents apoptosis in acute myeloid leukemia cells
Authors: Kim Ju-Heon , Kim Hyeng-Soo , Lee Sanggyu
Published: July 2023

Objectives

The B cell lymphoma-2 (BCL-2) protein group is essential for regulating apoptosis. BCL2L13 harbors all BH domains present in the BCL-2 protein family in addition to a BHNo domain comprising 250 amino acids at its C-terminal. BCL2L13 is highly expressed in AML and is involved in apoptosis. We investigated the possibility of discovering BCL2L13 as a treatment target for acute leukemia.

Methods

We reduced the expression of BCL2L13 in Mono Mac 6 (MM6) cells using shRNA and overexpressed BCL2L13 in THP-1 cells. MM6 and THP-1 cells were treated with staurosporine (STS) to confirm the role of BCL2L13 in apoptosis.

Results

In acute myeloid leukemia (AML) cells, BCL2L13 is involved in inhibiting apoptosis as evidenced by its strikingly augmented expression in these cells. BCL-2 was downregulated and cleaved Caspase 3, and sphingosine-1-phosphate phosphatase 1 (SGPP1) was upregulated when MM6 cells with knockdown BCL2L13 were treated with STS, which significantly increased their apoptosis. Furthermore, mitochondrial membrane potential decreased in MM6 cells in response to the downregulation of BCL2L13. In BCL2L13-depleted MM6 cells, the amount of cytochrome c increased in the cytoplasm. The THP-1 cells overexpressing BCL2L13 and treated with STS showed a significant decrease in the expression of genes related to apoptosis induction, resulting in decreased apoptosis.

Conclusion

BCL2L13 inhibits apoptosis in AML, and BCL2L13-specific inhibition might serve as a new strategy for treating this condition.
Comprensión textual en la resolución de problemas matemáticos
Authors: Gibert Delgado Rosario del Pilar , Naranjo Vaca Gregory Edison , Gorina Sánchez Alexander
Published: July 2023

La enseñanza de la Matemática apoyada en la resolución de problemas es un enfoque didáctico con aceptación a nivel internacional. Sin embargo, se reporta que estudiantes universitarios aún tienen dificultades que les impiden tener éxito en esta actividad, siendo la comprensión del problema una de las etapas críticas. En consecuencia, el objetivo fue valorar la efectividad de la comprensión textual en la carrera de Educación Básica de la Universidad de Machala, Ecuador, a partir de la aplicación de una metodología que prioriza el uso de claves semánticas en la resolución de problemas matemáticos. La metodología permitió desarrollar acciones y aplicar criterios evaluativos para la identificación y descripción de claves semánticas y la generalización de su significado matemático en la enseñanza de la resolución de problemas matemáticos. Se concluye que la metodología aplicada está en condiciones de contribuir al perfeccionamiento de la enseñanza de la Matemática vía resolución de problemas, en lo fundamental, desde la comprensión textual.
Mobile craftspeople and orientalising transculturation in seventh-century BC Iberia
Authors: Blanco-González Antonio , Padilla-Fernández Juan Jesús , Dorado-Alejos Alberto
Published: July 2023

During the early first millennium BC, Phoenician peoples settled the Iberian coasts instigating cultural innovations known as the orientalising; indigenous communities of the interior have long been considered as passively dependent on, or isolated from, these developments. Recent excavations at the Early Iron Age village of Cerro de San Vicente in central Spain, however, have yielded domestic contexts that prompt reconsideration of this relationship. The authors use settlement layout, architecture and locally made tablewares to identify heterarchical organisation around virilocal and bilateral kinship and hybrid practices that attest to adoption of know-how and practices from distant places. Emphasis is placed on the role of embodied craftworking skills and female mobility in transculturation processes.
Understanding Gender-Based Violence Service Delivery in CDC-Supported Health Facilities: 15 Sub-Saharan African Countries, 2017–2021
Authors: Kanagasabai Udhayashankar , Valleau Christopher , Cain Meagan , Chevalier Michelle S. , Hegle Jennifer , Patel Pragna , Benevides Regina , Trika Joseph B. , Angumua Carrine , Mpingulu Minlangu , Ferdinand Kamanga , Sida Fikirte , Galloway Katelyn , Kambona Caroline , Oluoch Patricia , Msungama Wezi , Katengeza Hans , Correia Della , Duffy Meghan , Cossa Raquel Maria Violeta , Coomer Rachel , Ayo Adeola , Ukanwa Chioma , Tuyishime Elysee , Dladla Sibongile , Drummond Jennifer , Magesa Daniel , Kitalile Jane , Apondi Rose , Okuku Jackson , Chisenga Tina , Cham Haddi J.
Published: July 2023

Gender-based violence (GBV) is a complex issue deeply rooted in social structures, making its eradication challenging. GBV increases the risk of HIV transmission and is a barrier to HIV testing, care, and treatment. Quality clinical services for GBV, which includes the provision of HIV postexposure prophylaxis (PEP), vary, and service delivery data are lacking. We describe GBV clinical service delivery in 15 countries supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Centers for Disease Control and Prevention. Through a descriptive statistical analysis of PEPFAR Monitoring, Evaluation, and Reporting (MER) data, we found a 252% increase in individuals receiving GBV clinical services, from 158,691 in 2017 to 558,251 in 2021. PEP completion was lowest (15%) among 15–19-year-olds. Understanding GBV service delivery is important for policy makers, program managers, and providers to guide interventions to improve the quality of service delivery and contribute to HIV epidemic control.