bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Inflammatory Approach in Chronic Dialysis Patients with SARS-CoV-2: ATA or PMMA Dialyzers?
Authors: Donati Gabriele , Gasperoni Lorenzo , Napoli Marianna , Scrivo Anna , Zappulo Fulvia , Abenavoli Chiara , Hu Lilio , Angelini Andrea , Di Nunzio Miriam , Tringali Edoardo , Cingolani Alessandra , Marchegiani Beatrice Claudia , Rigotti Angelo , La Manna Gaetano
Published: November 2022

Introduction: High-flux hemodialysis membranes may modulate the cytokine storm of SARS-CoV-2, but their impact on chronic hemodialysis (CHD) patients is unknown. The aim of the study was the evaluation of asymmetric cellulose triacetate (ATA) and polymethylmethacrylate (PMMA) dialyzers on inflammatory markers and clinical outcomes in CHD patients with SARS-CoV-2. Methods: A prospective, observational study on CHD patients with SARS-CoV-2 was carried out. Patients were enrolled from March 2020 to May 2021. Pre- and postdialysis C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) were determined at each session. Patients who underwent on-line hemodiafiltration (OLHDF) with a PMMA dialyzer were compared with those treated with OLHDF with a ATA dialyzer. The primary endpoint was the differences in the reduction ratio per session (RR) of CRP, PCT, IL-6, and IL-6 RR >25%. Results: We consecutively enrolled 74 CHD patients with COVID-19, 48 were treated with ATA membrane, and 26 with PMMA. Median IL-6 RR was higher in the ATA group compared to PMMA (17.08%, IQR −9.0 to 40.0 vs. 2.95%, IQR −34.63 to 27.32). Median CRP RR was 7.77% (IQR 2.47–13.77) in the ATA group versus 4.8% (IQR −2.65 to 11.38) in the PMMA group (p = 0.0017). Median PCT-RR% was 77.38% (IQR 70.92–82.97) in ATA group versus 54.59% (IQR 42.62–63.16) in the PMMA group (p < 0.0001). A multiple logistic regression analysis with IL-6 RR >25% as the outcome including the membrane employed, pre-dialysis IL-6, CRP, PCT, and ferritin showed that ATA led to a higher probability to reach the outcome (OR 1.891, 95% CI 1.273–2.840, p = 0.0018) while higher CRP favors the risk of lower IL-6 RR values (OR 0.910, 95% CI 0.868–0.949, p ≤ 0.0001). Conclusions: In SARS-CoV-2 CHD patients treated with OLHDF, ATA showed a better anti-inflammatory profile, regarding IL-6 RR, compared to PMMA.
Technical and Clinical Outcomes of Using a Single Wide-Caliber Double-Pigtail Stent for Endoscopic Ultrasound-Guided Pancreatic Pseudocyst Drainage: A Multicenter Prospective Study
Authors: Ghoneem Elsayed , Okasha Hussein , Hammouda Mohamed , Gouda Mohamed Fathi , Soliman Reham , Shiha Gamal , Ragab Khaled , Agwa Ramy Hassan
Published: November 2022

Introduction: Endoscopic ultrasound (EUS)-guided pancreatic cysto-gastrostomy/duodenostomy is the current accepted practice for management of symptomatic pancreatic pseudocysts with insertion of two or more double-pigtail (DP) stents. There is no much work on the efficacy of using a single wide-caliber DP stent, aiming to decrease the time, complications, and accessories used in the procedure. Aim of the Work: The aim of this study was to assess technical and clinical outcomes of using a single wide-caliber DP stent in EUSguided pancreatic pseudocyst drainage. Methodology: This multicenter prospective study included 57 patients, from which the 35 patients with symptomatic pancreatic pseudocysts enrolled. Patients with cysts with multiple septations (7 cases) or cyst with >30% necrosis (8 cases) of the cyst content and patients with generalized ascites (4 cases) or patients with major comorbidities (3 cases) were excluded. Patients were followed up within 1 month and 6 months after stent placement to assess complete resolution or a decrease in the sizes of cysts with clinical symptomatic improvement. Results: From 57 patients, 35 patients (19 females/16 males, median age 40 years) with a symptomatic pancreatic pseudocyst were referred for EUS-guided drainage. All used stents were 10 Fr DP plastic stents. The median duration of the whole procedure was 16 min. Technical success was achieved in all cases. Clinical success was encountered in 32 patients (91.4%) without re-accumulation on follow-up. Minor adverse events were encountered in 3 patients (8.6%) including post-procedure abdominal pain (1 case) and fever (2 cases). Conclusion: We suggest that using a wide-caliber single-pigtail stent for EUS-guided cystogastrostomy is safe and effective with short procedure time, with reduced risks from the insertion of another stent(s).
Enhancing Sweat Rate Using a Novel Device for the Treatment of Congestion in Heart Failure
Authors: Aronson Doron , Nitzan Yaacov , Petcherski Sirouch , Bravo Evgeny , Habib Manhal , Burkhoff Daniel , Abraham William T.
Published: November 2022

Background:

Current treatment of fluid retention in heart failure relies primarily on diuretics. However, adequate decongestion is not achieved in many patients. We aimed to study the feasibility and short-term performance of a novel approach to remove fluids and sodium directly from the interstitial compartment by enhancing sweat rate.

Methods:

We used a device designed to enhance fluid and salt loss via the eccrine sweat glands. Skin temperature in the lower body was increased from 35 °C to 38 °C, where the slope of the relationship between temperature and sweat production is linear. The sweat evaporates instantaneously, thus avoiding the awareness of perspiration. The primary efficacy endpoint was the ability to increase skin temperature to the desired range. A secondary efficacy endpoint was a clinically meaningful hourly sweat output, defined as ≥150 mL/h. The primary safety endpoint was any procedure-related adverse events.

Results:

We studied 6 normal subjects and 18 patients with congestion. Participants underwent 3 treatment sessions of up to 4 hours. Skin temperature increased to a median of 37.5 °C (interquartile range, 37.1–37.9 °C) with the median core temperature increasing by 0.2 °C (interquartile range, 0.1–0.3 °C). The median hourly weight loss during treatment was 215 g/h (interquartile range, 165–285; range, 100–344 g/h). In 80% of treatment procedures, the average sweat rate was ≥150 mL/h. There were no significant changes in hemodynamic variables or renal function and no procedure-related adverse events.

Conclusions:

Enhancing sweat rate was safe and resulted in a clinically meaningful fluid removal and weight loss.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04578353.
In Defense of Modular Thinking
Authors: Wyble Brad
Published: November 2022

In this issue, Pessoa emphasizes the importance of viewing neural activity from a perspective that functional networks form dynamically in a way that dramatically changes the functional contribution of individual brain areas. In this response, I argue that we should strive toward pluralism in understanding neural activity at both the emergent network and modular levels, on the bases that a purely emergent understanding would be incomplete, and that there are computational advantages to anatomically stable modularity.
Machine Learning for Ranking Factors of Global and Regional Protest Destabilization with a Special Focus on Afrasian Instability Macrozone
Authors: Medvedev Ilya , Ustyuzhanin Vadim , Zinkina Julia , Korotayev Andrey
Published: November 2022

Based on the experience of previous studies, the authors use machine learning methods at two levels for evaluating predictors of instability. First, they analyze the factors that lead to instability in general; second, they focus on the factors that influence the intensity of instability. Their analysis relies on data on mass protest destabilization. The system for assessing predictors of nonviolent destabilization is modernized and a two-level model is developed for ranking the factors of instability. After that, using Shapley vectors, all predictors within the final model are estimated and quantified. The authors analyze several subsamples: the world as a whole, the World System core and periphery, and the Afrasian instability macrozone. The result shows that the division of the original database into world-system zones, as well as specifying the Afrasian zone as a separate entity makes sense. The results obtained through machine learning are further cross-validated with more traditional regression models.
Oblique Paths to Truth – Myth and Bodily Elements in Simone Weil, Jeanne Hersch and María Zambrano
Authors: Severini Piergiacomo
Published: November 2022

The aim of this paper is to analyze in which way Simone Weil, Jeanne Hersch and María Zambrano relaunch bodily elements both in the rational search for truth and in the language they use for expressing it. In particular, the focus is on these women philosophers’ reflection on well-known myths and mythical stories which show how bodily elements precede consciousness and reason. In these stories, it emerges the impossibility of knowing the Truth directly through the objects and the necessity of elaborating indirect paths to transcendent truth. This paper should shed light on the endeavour to reintegrate the human bind to the marginal world, which is peculiar to women philosophers in the History of Philosophy, thus indicating a path to the human search for meaning that is alternative to the mainstream Western male philosophical one.
PATMOS-x Version 6.0: 40 Years of Merged AVHRR and HIRS Global Cloud Data
Authors: Foster Michael J. , Phillips Coda , Heidinger Andrew K. , Borbas Eva E. , Li Yue , Menzel W. Paul , Walther Andi , Weisz Elisabeth
Published: November 2022

A new version of the PATMOS-x multidecadal cloud record, version 6.0, has been produced and is available from the NOAA National Centers for Environmental Information. A description of the processes and methods used for generating the dataset are presented, with a focus on the differences between version 6.0 and the previous version of PATMOS-x, version 5.3. The new version appears both to be more stable, with less intersatellite variability, and to have more consistent polar cloud detection, phase distribution, and cloud-top height distribution when compared against the MODIS EOS record. Improvements in consistency and performance are attributed to the addition of multidimensional variables for cloud detection, constraining cloud retrievals to radiometric bands available throughout the record, and the addition of data from the HIRS instrument.

Significance Statement

The PATMOS-x project produces multidecadal cloudiness records from polar-orbiting satellites. Version 6.0 combines imager and sounder data from 15 satellites and shows significant improvements in accuracy and stability.
Improving Confidence in Model-Based Probable Maximum Precipitation: How Important is Model Uncertainty in Storm Reconstruction and Maximization?
Authors: Tarouilly Emilie , Cannon Forest , Lettenmaier Dennis P.
Published: November 2022

We analyze uncertainty in model-based estimates of probable maximum precipitation (PMP) as used in dam spillway design. Our focus is on model-based PMP derived from Weather Research and Forecasting (WRF) Model reconstructions of severe historical storms, amplified by the addition of moisture in the boundary conditions [so-called relative humidity maximization (RHM)]. By scaling moisture and predicting the resulting precipitation, the model-based approach arguably is more realistic than currently used techniques [documented in NOAA’s Hydrometeorological Reports (HMRs)], which assume that precipitation scales linearly with moisture. Despite the important improvement this represents, model-based PMP is subject to several sources of uncertainty that have slowed adoption in operational settings. We analyze an ensemble of PMP simulations that reflect recognized sources of uncertainty including the following: 1) initial condition error, 2) choice of physics parameterizations, and 3) upscale propagating model errors. We apply this ensemble approach to the Feather River watershed (Oroville Dam) in California for the storms of February 1986 and January 1997, which produced some of the largest floods on record at that location, after carrying out in-depth evaluations of model reconstructions. Differences in the maximized 72-h precipitation totals across the 56 ensemble members we produced for each storm are modest, ranging from ±7% of ensemble mean. Our results suggest that while model-based PMP estimates should be interpreted as a range of values, model uncertainty appears to be relatively small for the major atmospheric river–driven flood events we investigated.
Two Minutes for Roughing: A National Analysis of Ice Hockey Injuries from American Trauma Centers
Authors: Owattanapanich Natthida , Schellenberg Morgan , Emigh Brent , Grigorian Areg , Martin Matthew J. , Inaba Kenji
Published: November 2022

Background

Hockey is a high-impact sport that carries a risk of injury. No national-level studies defining the burden of injury in this sport have yet been performed. This study sought to analyze patient demographics, injury types and severity, and outcomes after trauma sustained while playing hockey.

Methods

Retrospective analysis of hockey-related injuries was performed using the National Trauma Data Bank (NTDB) (2007-2018). Patients were identified based on ICD-9 and -10 codes without exclusions. Demographics, clinical/injury data, and outcomes were examined using univariate analysis. Subgroup analysis was performed by patient sex.

Results

Hockey injuries (n = 306) comprised <1% of the NTDB. Median age was 15 years [IQR 13-25] (range 5-71). Most patients (n = 279, 91%) were male. Lower extremities were the most frequently injured body region (n = 88, 29%). Head injuries occurred in 19% (n = 57). Facial injuries occurred in 6% (n = 17). Tooth loss was infrequent (n = 2, 1%). One (<1%) death occurred after a hockey-related brain injury. Clinical/injury data between male and female hockey players were comparable apart from a significantly higher rate of upper extremity fractures among the female cohort (22% vs 4%, P < .001).

Conclusion

Perceptions that hockey players may frequently sustain head, face, and tooth injuries from collisions, fighting, or stick/puck impacts were not supported by this national-level study, in which lower extremity fractures were the most common injury. While hockey injury prevention equipment has primarily focused on head/face protection (eg, helmets and mouthguards), this analysis suggests increased focus on extremity protective measures is warranted.
Factors affecting the need of postoperative blood transfusion in elderly patients with intertrochanteric hip fracture
Authors: Cho Myung-Rae , Cho Young-Jae , Song Suk-Kyoon
Published: November 2022

Introduction:

We investigated the risk factors that increased the frequency of blood transfusions in elderly patients with intertrochanteric hip fractures to determine blood transfusion risk before surgery and to take selective precautionary measures in the group at high risk for transfusion to ensure safe surgery.

Materials and methods:

We retrospectively reviewed the electronic medical records of 203 patients who underwent surgical fixation of intertrochanteric hip fractures from January 2015 to December 2020. We hypothesized that patient sex, age, body mass index, preoperative hemoglobin, preoperative platelet count, glomerular filtration rate (GFR), preoperative albumin level, American Society of Anesthesiologist score, intraoperative blood loss, duration of surgery, method of anesthesia, and time from injury to surgery would affect the need for blood transfusion. Student's t-test, Chi-squared test, and the one-way analysis of variance test were used to determine whether differences between variables in the transfusion and non-transfusion groups were significant.

Results:

Unstable fractures ( P = 0.002), general anesthesia ( P = 0.028), lower preoperative hemoglobin levels ( P < 0.001), and lower GFRs ( P < 0.001) were identified as related to blood transfusions in univariate analysis. In multivariate logistic analysis, the need for allogeneic blood transfusion in unstable fractures was approximately 2.949 times higher than in stable fractures ( P = 0.009). The risk in general anesthesia patients was about 2.953 times higher than in spinal anesthesia patients ( P = 0.007). In addition, the need for allogeneic blood transfusion increased by about 1.293 times as preoperative hemoglobin levels decreased by 1 g/dL ( P = 0.017) and increased by about 1.017 times as the GFR decreased by 1 mL/min/1.7m2 ( P = 0.006).

Conclusion:

Low preoperative hemoglobin levels, low GFRs, general anesthesia, and unstable fractures in elderly patients with intertrochanteric hip fractures increased the risk of blood transfusion.
Variations of Gender Gaps in the Labour Market Outcomes of Graduates across Fields of Study: A (Combined) Test of Two Theories
Authors: Galos Diana Roxana , Kulic Nevena
Published: November 2022

Unequal gender outcomes in occupational success unravel through different channels in higher education. Using the AlmaLaurea dataset comprised of 80% of Italian graduates and 98 fields of study, this article investigates whether men and women receive similar returns on employment and earnings when choosing the same field of study. Two complementary perspectives are applied – Kanter’s theory of relative numbers and the status theory of gender – to examine the quantitative and qualitative differences between fields. The results show that the most gender ‘balanced’ fields of study are the most gender unequal in terms of earnings and employment. Separate analyses demonstrate that the status of a field interacts with its gender composition, and gender gaps in female-intensive nurturing fields shrink faster with an increasing proportion of women, albeit at higher absolute levels compared with non-nurturing fields. Therefore, nurturing fields of study should not necessarily be considered as levelling gender inequality in the labour market.
Nurturing student ethnic identity through culturally responsive music teaching in China
Authors: Guan Tao , Luo Ning , Matsunobu Koji
Published: November 2022

A multicultural approach has been advocated in school music education in China to heighten the sense of ethnic identity among students from diverse backgrounds, but research has shown that inadequate teaching approaches have been a major challenge in implementing multiculturalism. To facilitate students’ development of their sense of ethnic and cultural identity, international educators have advocated the use of culturally responsive teaching (CRT), which can provide Chinese teachers with pedagogical guidance to put multiculturalism into practice. A mixed methods intervention approach was adopted to explore the impact of CRT on the ethnic identities of Yi, Han, Mongolian and Tibetan students in a multi-ethnic school in Sichuan Province, China. The quantitative results revealed that after participating in the CRT music course, the students demonstrated statistically significant improvement across the four dimensions of ethnic identity. The qualitative findings attributed the improvement in the students’ ethnic identities to the use of ethnic music and native languages, multiple roles of the local music teacher and collective musical engagement. This study contributes to research on pedagogical strategies that help facilitate cultural diversity in school music education in China, and it serves as a reference for the use of CRT worldwide.
Efficacy and safety of aquatic exercise in knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials
Authors: Xu Zhen , Wang Yidi , Zhang Yue , Lu Yifan , Wen Yuhong
Published: November 2022

Objective

To examine the efficacy and safety of aquatic exercise for people with knee osteoarthritis.

Data sources

PubMed, Web of Science, Embase, CENTRAL, CNKI and WanFang databases were searched from 1966 to September 2022.

Review methods

Randomized controlled trials evaluating aquatic exercise for people with knee osteoarthritis compared with no exercise and land-based exercise were included. The Grading of Recommendations Assessment, Development and Evaluation system was used to evaluate the certainty of evidence.

Results

Twenty-two studies with 1394 participants were included. Compared with no exercise (13 trials with 746 participants), low-to high-certainty evidence revealed that aquatic exercise yielded significant improvements in patient-reported pain (SMD −0.58, 95% CI −0.82 to −0.33), stiffness (SMD −0.57, 95% CI −1.03 to −0.11) and physical function (SMD −0.35, 95% CI −0.52 to −0.18) immediately postintervention. A sustained effect was observed only for pain at three months postintervention (SMD −0.48, 95% CI −0.91 to −0.06). The confidence intervals demonstrated that the pooled results do not exclude the minimal clinically important differences. There were no significant differences between the effects of aquatic exercise and land-based exercise (13 trials with 648 participants) on pain (SMD −0.12, 95% CI −0.29 to 0.04), stiffness (SMD −0.17, 95% CI −0.49 to 0.16) or physical function (SMD −0.13, 95% CI −0.28 to 0.02). No study reported a serious adverse event in relation to aquatic exercise.

Conclusion

Aquatic exercise provides a short-term clinical benefit that is sustained for at least three months postintervention in terms of pain in people with knee osteoarthritis.
Paeniclostridium sordellii–associated peripartum metritis in goats
Authors: Gonzalez-Astudillo Viviana , Asin-Ros Javier , Moore Janet , Uzal Francisco A. , Navarro Mauricio A.
Published: November 2022

Paeniclostridium sordellii is involved in enteric and histotoxic infections in several animal species. In humans, P. sordellii has been linked to gynecological disease, an association not previously investigated in animals. To unveil a potential association of P. sordellii with veterinary reproductive disease, a retrospective search of the database of the California Animal Health and Food Safety Laboratory System (1990–2020) was conducted and identified 9 cases of goats with P. sordellii-associated metritis or endometritis that were confirmed by immunofluorescence antibody test and/or bacterial isolation, and often co-colonized by Escherichia coli. Six of 9 does were also copper deficient. Polymerase chain reaction (PCR) on formalin-fixed, paraffin-embedded uterine tissue identified the sordellilysin gene in all 9 cases, and the lethal toxin gene in 4. Our findings suggest goats could be predisposed to P. sordellii-associated endometritis/metritis and toxemia when co-infected with E. coli. The role of mineral deficiencies influencing vulnerability to puerperal bacterial infections in goats is possible but remains undetermined. To our knowledge, this is the first report documenting the association of P. sordellii with veterinary gynecological disease.
Free rider recognition—A missing link in the Baldwinian model of music evolution
Authors: Podlipniak Piotr
Published: November 2022

The interactions between species-specific predispositions and cultural plasticity in the development of human musical behavior have recently become the rationale for a possible Baldwinian origin of human musicality. In the previously suggested Baldwinian scenarios of music origin, social bonding has been indicated as the crucial adaptive value that became the main cause of the co-evolutionary process that led to our musicality. However, the adaptive value of social bonding does not explain the cultural variability of musical expressions that enabled the Baldwinian evolution of musicality. The main aim of this article is to show that free rider recognition, along with social bonding and signaling commitment, could have been a possible adaptive function of hominin musical rituals. In the proposed scenario, free rider recognition became a “flywheel” of the arms race between deception and cooperation. As a result, the interplay between the canalization and plasticity of musical learning became a part of music evolution. This process created a cultural niche in which hominin vocal learning was specialized in the imitation of discrete pitch and rhythm.
Optimization and prediction of incremental sheet forming parameters of Titanium grade 5 sheet using a response surface methodology and artificial neural network
Authors: C Veera Ajay , S Elangovan , AS Kamaraja , K Karthik Kumar , S Pratheesh Kumar
Published: November 2022

Single point incremental forming (SPIF) is an advanced, flexible, and cost-effective approach for producing complicated sheet metal objects quickly. Because of its low equipment cost, the process is best suited toward low or medium quantity batch production as the conventional stamping method remains cost-effective only for mass manufacture. During SPIF formation of titanium grade 5 materials, a response surface methodology and artificial neural network (ANN) model was created to optimize and estimate wall angle (Ømax) and average surface roughness ( Ra). The ANN model is developed using feed forward back propagation networks. Various combinations of transfer functions and number of neurons were used to create the ANNs (3- n-1, 3- n-2). The confirmation runs have been used to ensure that the ANN anticipated and practical findings have been in agreement. The generated ANN model (3- n-1) was capable of accurately forecasting the results of the experiment, with an overall R-value and Mean Square Error (MSE) of 0.99987 and 0.010905 for Ra, and 0.99999 and 0.00700 for wall angle. The best 3- n-2 models has an average R-value of 0.99992 and MSE of 0.05532, respectively. As a consequence of rapid ANN modeling technique, it became discovered that technical effort inside the SPIF process could be decreased.
The experimental assessment of carbon nanotubes incorporation on the tensile and impact properties of fiber metal laminate fabricated by jute/basalt fabrics-aluminum layers: As hybrid structures
Authors: Mirzamohammadi Sadegh , Eslami-Farsani Reza , Ebrahimnezhad-Khaljiri Hossein
Published: November 2022

In this work, the simultaneous effect of different stacking sequences of basalt/jute fibers and adding the various weight fractions of carbon nanotubes (CNTs) on the mechanical features of fiber metal laminates (FMLs) under the tensile and impact conditions was assessed. According to the results, the FML had the highest performance under the mechanical tests, when the jute layers were sandwiched by the basalt fibers. In contrast, by sandwiching the basalt fibers with the jute fibers, the FML showed the weakest performance just under the tensile test. This configuration had the moderate performance under the impact test. Incorporating 0.3 wt.% CNTs in all configurations caused to reach the highest improvement in the tensile strength, elastic modulus and impact energy, which were 301 MPa, 50.9 GPa, and 12.3 J, respectively. Reinforcing an adhesion between skin/core and enhancing the mechanical properties of composite core were the effective factors for improving the tensile properties. The delamination of layers, fibrillation of jute fibers, creation of imprint phenomenon, and pull out the basalt fibers were the characterized wasting mechanisms under the impact conditions.
Complete effect decomposition for an arbitrary number of multiple ordered mediators with time-varying confounders: A method for generalized causal multi-mediation analysis
Authors: Tai An-Shun , Lin Sheng-Hsuan
Published: November 2022

Causal mediation analysis is advantageous for mechanism investigation. In settings with multiple causally ordered mediators, path-specific effects have been introduced to specify the effects of certain combinations of mediators. However, most path-specific effects are unidentifiable. An interventional analog of path-specific effects is adapted to address the non-identifiability problem. Moreover, previous studies only focused on cases with two or three mediators due to the complexity of the mediation formula in a large number of mediators. In this study, we provide a generalized definition of traditional path-specific effects and interventional path-specific effects with a recursive formula, along with the required assumptions for nonparametric identification. Subsequently, a general approach is developed with an arbitrary number of multiple ordered mediators and with time-varying confounders. All methods and software proposed in this study contribute to comprehensively decomposing a causal effect confirmed by data science and help disentangling causal mechanisms in the presence of complicated causal structures among multiple mediators.
Development and Validation of the Disclosure Expectancy Scale
Authors: Clapp Joshua D. , Gray Matt J. , Litz Brett T. , Lang Ariel J. , Sowers Alexandria F.
Published: November 2022

Although the disclosure of traumatic experiences is believed to influence trajectories of post-trauma recovery, less is known about individual differences that affect survivors’ motivation to share. The current project describes the development and evaluation of the Disclosure Expectancy Scale (DExS), a novel instrument intended to assess survivors’ expectations about the potential risks and benefits of disclosure. Items targeting both positive and negative expectancies were generated based on existing research and the authors’ clinical experience with various survivor populations. Preliminary analyses in trauma-exposed undergraduates ( N = 359) offer support for hypothesized positive and negative expectancy dimensions with evidence for the convergent and discriminant validity of scores. Subsequent evaluation in active-duty, help-seeking military personnel ( N = 35) provides further evidence of validity based on correlations with relevant clinical measures. A final regression demonstrating unique effects of initial disclosure expectancies on post-traumatic stress disorder (PTSD) severity following trauma-focused treatment highlights the predictive validity of DExS scores.
Homeopathic Manganum in the Management of Post Dural Puncture Headache, A Case Series
Authors: Ivanenko Ekaterina , Belagaje Amritha , Mahesh Seema , Vithoulkas George
Published: November 2022

Post-dural puncture headache (PDPH) is a functional condition caused by disruption of the dural membrane with low cerebrospinal fluid pressure, affecting 4% to 11% of the patients who undergo procedures where the spinal canal is purposefully punctured. It has a significant impact on the quality of life of those affected. We present 12 cases diagnosed with PDPH, unresponsive to usual treatment, who were treated with classical homeopathy. Nine of the 12 cases showed complete recovery, while the remaining 3 cases showed partial improvement. The author has stressed on the importance of pathology-based prescriptions, in his teachings and also the importance of appreciating the pathology as emphasized in homeopathic literature. The homeopathic remedy Manganum helped in the improvement of 9 of the 12 cases, with promising results. Further controlled studies are needed to determine the role and mechanism of PDPH resolution via homeopathic Manganum.
Money is no object: Money, cryptocurrency, fiction
Authors: Haynes Paul
Published: November 2022

Georg Simmel depicts money as an evolving entity that will continue to evolve to a state of ‘perfect money’ disconnected from any external guarantor of value. This article examines some of the different approaches to substantial value underpinning money, suggesting that they represent different types of fictional underwriting. Money is then contrasted with cryptocurrency, suggesting that their respective value is not only derived from different fictions but from different standards of value as major and minor currency. This analysis suggests that far from evolving into a fully abstract and functional instrument for creating stable social relationships, the divergence in currencies and currency fictions is a force for overturning such ‘expedient’ stability.
Motor Cognitive Dual-Task Testing to Predict Future Falls in Multiple Sclerosis: A Systematic Review
Authors: Abou Libak , Peters Joseph , Fritz Nora E. , Sosnoff Jacob J. , Kratz Anna L.
Published: November 2022

Background

Mobility and cognitive impairments are often associated with increased fall risk among people with multiple sclerosis (PwMS). However, evidence on the concurrent assessment of gait or balance and cognitive tasks (dual-task) to predict falls appears to be inconsistent.

Objective

To summarize the ability of gait or balance dual-task testing to predict future falls among PwMS.

Methods

Seven databases including PubMed, Embase, Web of Science, Scopus, CINHAL, SPORTDiscuss, and PsycINFO were searched from inception to May 2022. Two independent reviewers identified studies that performed a dual-task testing among adults with multiple sclerosis and monitored falls prospectively for at least 3 months. Both reviewers also evaluated the quality assessment of the included studies.

Results

Eight studies with 484 participants were included in the review. Most studies (75%) indicated that dual-task testing and dual-task cost did not discriminate prospective fallers (⩾1 fall) and non-fallers (0 fall) and were not found as predictors of future falls. However, dual-task cost of walking velocity (OR = 1.23, 95% CI 0.98-4.45, P = .05) and dual-task of correct response rate of serial 7 subtraction (OR = 1.34, 95% CI 1.04-3.74, P = .02) were significantly associated with increased risk of recurrent falls (≥2 falls). Pattern of cognitive-motor interference was also associated with an increased risk of falling. All studies presented with strong quality.

Conclusion

The scarce evidence indicates that dual-task testing is not able to predict future falls among PwMS. Further research with more complex motor and cognitive tasks and longer-term fall monitoring is required before dual-task testing can be recommended as a predictor of future falls in this population.
Energy conservation, minimum steps, and adaptations when needed: A scoping review
Authors: Omura Kátia Maki , Augusto de Araujo Costa Folha Otavio , Moreira Paula Silva , da Silva Bittencourt Estéfanny , Seabra Adriene Damasceno , Cardoso Marcelo Marques
Published: November 2022

Background/objective

Although many therapeutic approaches use energy conservation, only a few effectively report the steps involved. Thus, it is intended to identify energy conservation practices to be organized in flexible and adaptable stages.

Methods

A scoping review was carried out, whose search strategies were applied in seven databases (CINAHL, Cochrane Library, Portal BVS, PsycINFO, PubMed, Scopus, and Web of Science) following guidelines by Arksey and O’Malley on the Rayyan software. Searches were carried out from January 2010 to December 2020. Inclusion of refered publications with different study designs, participation of adults with or by demands of energy conservation, joint protection, and control of fatigue and/or pain. Exclusion of productions without an occupational therapist or involving merely pharmacological or surgical therapeutic strategies.

Results

653 articles were identified, after the selection and eligibility steps, 30 articles were full review, 18 articles were included and 635 excluded. Energy conservation studies have been increasingly focusing on neurological and systemic diseases, especially regarding symptoms of fatigue and pain. The findings were arranged in six strategies whose interventions are essentially based on guidelines and setting goals for patients, client-centered approach. Merely supervised interventions are less frequent. The number of sessions is closed, but the duration of treatment is not yet.

Conclusions

The signs of pain and fatigue are confirmed as indicators of energy conservation strategies, this delivery can be condensed from planning and organization, priorities, activity analysis, balance between activity and rest, outsourcing of tasks and physical/environmental adaptation.

Trial Registration, OSF

https://osf.io/rsyq4.
How to coach: A review of theoretical approaches for the development of a novel coach education framework
Authors: Smith Kevin , Burns Con , O’Neill Cian , Duggan John D , Winkelman Nick , Wilkie Matthew , Coughlan Edward K
Published: November 2022

Coaching behaviours often derive from sporting traditions, instinct and previous experiences. Practitioners tend to follow traditional, inherited methods rather than adopt new evidence-based approaches associated with athlete development. This article reviews literature relating to theoretical constructs of a novel coach education framework (CEF) developed by the Irish Rugby Football Union. The three constructs included are: self-determination theory (SDT), explicit learning theories (ELT) and implicit learning theories (ILT). A total of 82 publications met the inclusion criteria (SDT: n = 18, ELT: n = 28, ILT: n = 36). This review supports the efficacy of these constructs in isolation for promoting effective coaching practices and provides a justification for future implementation of the framework and its evaluation. This framework may have the potential to address a shortfall in current coach education formats, which have traditionally focused on What content should be used for athlete development as opposed to How practitioners can coach more effectively.
Netrin-1 Secreted by Human Osteoarthritic Articular Chondrocytes Promotes Angiogenesis in Vitro
Authors: Akoum Joulnar , Corvol Marie-Thérèse , Tahiri Khadija , Anract Philippe , Biau David , Borderie Didier , Étienne François , Rannou François , Nguyen Christelle
Published: November 2022

Objective

Netrin-1 expression in articular cartilage is correlated with osteoarthritic changes. We aimed to investigate the contribution of Netrin-1 secreted by human osteoarthritic articular chondrocytes to angiogenesis process in vitro.

Design

Human articular chondrocytes were extracted from non-osteoarthritic ( n = 10) and osteoarthritic ( n = 22) joints obtained from surgical specimens and incubated for 24 hours. Medium conditioned by non-osteoarthritic and osteoarthritic articular chondrocytes were collected. Human umbilical vein endothelial cells (HUVEC) were treated with control and conditioned medium and assessed using assays for cell adherence, migration, and tube formation. Netrin-1 expression and secretion was compared between non-osteoarthritic and osteoarthritic chondrocytes by qPCR, Western blot, and ELISA. The role of chondrocyte-secreted Netrin-1 on HUVEC functions was assessed by immunological neutralization using an anti-Netrin-1 monoclonal antibody.

Results

As compared with medium conditioned by non-osteoarthritic chondrocytes, medium conditioned by osteoarthritic chondrocytes permitted tube formation by HUVEC. Both non-osteoarthritic and osteoarthritic chondrocytes expressed Netrin-1 at the RNA and protein levels. At the RNA level, Netrin-1 expression did not differ between non-osteoarthritic and osteoarthritic chondrocytes. At the protein level, Netrin-1 appeared as a full protein of 64 kDa in non-osteoarthritic chondrocytes and as two cleaved proteins of 55 kDa and 64 kDa in osteoarthritic chondrocytes. Immunological neutralization of endogenous Netrin-1 reduced the pro-angiogenic and pro-inflammatory transcriptional profile of HUVEC treated with the medium conditioned by osteoarthritic chondrocytes, as well as their capacities to form tubes.

Conclusions

Medium conditioned by osteoarthritic chondrocytes permits tube formation by HUVEC in vitro. This permissive effect is mediated by Netrin-1.
Computed Tomographic 3-Dimensional Virtual Dissection Aiding in Diagnosis and Surgical Planning of a Rare Form of Obstructed Supracardiac Total Anomalous Pulmonary Venous Connection With an Unusual Scimitar-Like Arrangement
Authors: Leone David M. , Gruber Peter J. , Pesce Meredith , Lee Madonna , Brown Cary , Ghiroli Stephen , Steele Jeremy M.
Published: November 2022

We present a case of a newborn with a rare presentation of obstructed supracardiac total anomalous pulmonary venous connection who required emergent cannulation to extracorporeal membrane oxygenation (ECMO). Computed tomographic angiography of the heart was performed and using novel virtual dissection techniques aided in surgical planning and guidance. Computed tomographic angiography can be successfully performed in neonates with complex congenital heart disease on ECMO without adjustment of flows to aid in surgical management and novel virtual dissection techniques aid in complex anatomical delineation and spatial orientation with noncardiac structures. The preoperative imaging in this case allowed for appropriate and detailed presurgical planning and contributed to the excellent outcome of this patient.
Long-term risk of relapse in immune-mediated thrombotic thrombocytopenic purpura and the role of anti-CD20 therapy
Authors: Doyle Andrew J. , Stubbs Matthew J. , Dutt Tina , Lester Will , Thomas Will , van Veen Joost , Hermans Joannes , Cranfield Tanya , Hill Quentin A. , Clark Amanda , Bagot Catherine , Austin Steven , Westwood John-Paul , Thomas Mari , Scully Marie
Published: November 2022

Disease relapse is recognized as a risk in immune-mediated thrombotic thrombocytopenic purpura (iTTP) after treatment of the acute presenting episode. Identification of patients at risk of relapse and its patterns are yet to be clearly established. We reviewed patients with iTTP having had >3 years of follow-up over 10 years in the United Kingdom to identify patient characteristics for relapse, assess relapse rates and patterns, and response to anti-CD20 therapy in those with a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) relapses (ADAMTS13 activity of <20% without thrombocytopenia). We identified 443 patients demonstrating relapse rates of 40% at 5-year follow-up. At 10-year follow-up, no difference in relapse was observed irrespective of whether rituximab was used at acute presentation (P = .39). Black Caribbean ethnicity increased the risk of disease relapse in the British population. There was a distinct population of patients (6%) that relapsed early with subsequent frequent relapses occurring on average within 2 years (average time to relapse in subgroup, 1.7 years). Overall, nearly 60% of relapses described were ADAMTS13 relapses, with subsequent treatment reducing the risk of progression to clinical relapses. We demonstrate that iTTP diagnosed in the latter part of the study period had lower rates of clinical relapses (22.6% vs 11.1%, P = .0004) with the advent of regular monitoring and preemptive rituximab. In ADAMTS13 relapses, 96% responded to anti-CD20 therapy, achieving ADAMTS13 activity of >20%. Anti-CD20 therapy was demonstrated to be an effective long-term treatment regardless of relapse pattern and there was no loss of this treatment response after subsequent treatment episodes.
Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings
Authors: Garcia Jacqueline S. , Flamand Yael , Penter Livius , Keng Michael , Tomlinson Benjamin K. , Mendez Lourdes M. , Koller Paul , Cullen Nicole , Arihara Yohei , Pfaff Kathleen , Wolff Jacquelyn O. , Brunner Andrew M. , Galinsky Ilene , Bashey Asad , Antin Joseph H. , Cutler Corey , Ho Vincent , Jonas Brian A. , Luskin Marlise R. , Wadleigh Martha , Winer Eric S. , Savell Alexandra , Leonard Rebecca , Robertson Taylor , Davids Matthew S. , Streicher Howard , Rodig Scott J. , Ritz Jerome , Wu Catherine J. , DeAngelo Daniel J. , Neuberg Donna , Stone Richard M. , Soiffer Robert J.
Published: November 2022

Two articles in this week’s issue focus on the use of ipilimumab and decitabine for patients with myelodysplasia (MDS) and acute myeloid leukemia (AML) before and after hematopoietic stem cell transplantation (HSCT) for high-risk disease. In the first article, Garcia et al report on the results of a phase 1 trial of the combination in 54 patients, demonstrating overall response rate of 52% in patients who are HSCT-naïve and 20% in patients post-HSCT; responses are usually short-lived. In the second article, Penter and colleagues characterize gene expression responses to therapy and conclude that decitabine acts directly to clear leukemic cells while ipilimumab acts on infiltrating lymphocytes in marrow and extramedullary sites. Responses are determined by leukemic cell burden and by the frequency and phenotype of infiltrating lymphocytes. Increasing bone marrow regulatory T cells is identified as a potential contributor to checkpoint inhibitor escape.
Lung hyperinflation and flow limitation in chronic airway obstruction
Authors: Pellegrino R , Brusasco V
Published: November 2022

We reasoned that if flow limitation plays an important role in lung hyperinflation, then bronchodilatation should be associated with a decrease of functional residual capacity (FRC) only in subjects breathing under conditions of flow limitation. This hypothesis was tested in 33 subjects with chronic airway narrowing due to asthma or chronic obstructive pulmonary disease (COPD). Flow limitation during tidal breathing was inferred from the impingement of the tidal flow-volume loop on the flow recorded during submaximally forced expiratory manoeuvres initiated from end-tidal inspiration. At baseline, flow limitation during tidal breathing was present in seven asthmatic (Group 1) and eight COPD subjects (Group 2), but absent in 11 asthmatic (Group 3) and seven COPD subjects (Group 4). FRC (mean+/-SEM) was similar in the four groups (range 117+/-7 to 134+/-6% of predicted). Inhalation of salbutamol (200 microg) caused significant increments of the forced expiratory volume in one second (FEVI) (range 6+/-1 to 21+/-8% of baseline) and forced expiratory flows at 30% of baseline forced vital capacity (V'30) (range 58+/-13 to 235+/-93% of baseline) in all groups. In groups with flow limitation during tidal breathing at baseline the FRC measured by plethysmography decreased significantly (12+/-2% in Group 1, and 9+/-2% in Group 2), and the inspiratory capacity (IC) measured by spirometry increased significantly (17+/-3% in Group 1 and 7+/-3% in Group 2). This was associated with flow limitation disappearing at the volume of baseline end-tidal expiration. In Groups 3 and 4 neither FRC nor IC changed significantly. The breathing pattern was not modified in any group after salbutamol. These findings suggest that flow limitation may contribute to generation of lung hyperinflation both in asthma and chronic obstructive pulmonary disease. We speculate that the increment of functional residual capacity could be triggered by dynamic airway compression downstream from the flow-limiting segment.