bluuebunny/crossref_metadata_2025 huggingface dataset:
Accurate prediction of gaseous isotopes Xe and Kr concentrations from the burnup of nuclear fuel using simple regression algorithm
Authors: Nafee Sherif S. , Al-Ramady Amir M. , Mohamed Nader M. , Alshammari Manal F.
Published: July 2023

Mathematical techniques for modeling and simulating dangerous or complex systems, such as nuclear technology systems, often require high-performance computing to process and analyze available data. In this paper, simple and quick method to support studies and research related to nuclear fuel is presented. This reasonably simple method helps to predict different concentrations of actinides and fission products in nuclear fuels without the need for expensive specialized programs and highly-trained researchers. The great importance of this approach is the speed of predicting the components of nuclear fuel concentrations, which in turn leads to quick decision-making, such as the possibility of operating fuel at higher burnup values, predicting the amount of gases resulting from nuclear fission (which may accumulate and cause problems in nuclear fuel such as volume swells), and other important decisions in nuclear fuel technology. The predicted equations have been generalized for higher values of burnup and compared with comparable results from MCNP codes. The equations deduced in calculating the different concentrations of xenon and krypton isotopes resulting from fission in burnup of nuclear fuel showed very precise results with discrepancies (magnitude of an error between the data points and the corresponding predicted ones) less than 2%. The suggested method offers a great advantage for researchers, which are the use one of any simple or common computational programs available to most researchers and do not need much experience to deal with, such as MATLAB, Excel that are easy to use for regression analyses. In this paper, the advantages of the proposed method are explained along with the limitations of its use.
Práticas discursivas contra a naturalização das desigualdades
Authors: Masquio de Souza Felipe , Oliveira Sargentini Vanice Maria
Published: July 2023

O objetivo deste artigo é discutir como as práticas discursivas que alimentam um dispositivo, na acepção de Foucault, atuam na naturalização das desigualdades. Desenvolve-se a análise de um discurso aparentemente homogêneo da campanha e da ação solidária da empresa Açúcar Guarani, em material divulgado nas redes sociais em 2022, a propósito de nomes tradicionais de doces, considerados politicamente incorretos e ofensivos às chamadas minorias. Com base nos postulados revisitados da Análise do Discurso foucaultiana, cotejando textos verbais e não verbais da campanha, foi possível perceber como a heterogeneidade está presente de forma simultânea num dispositivo colonial e decolonial. A análise apontou ainda que é no discurso em que são conflagradas as contradições entre as práticas sociais. Para isso, no que diz respeito à mulher e à mulher negra, analisou-se também os movimentos de interdição dos dizeres, o politicamente correto e o lugar de fala como movimentos correlatos da noção de “liberdade de expressão”, amplamente divulgada em nosso século nos países do mundo ocidental.
Combined use of non-steroidal anti-inflammatory drugs and symptomatic slow-acting drugs in musculoskeletal diseases
Authors: Karateev A. E. , Lila A. M. , Parfenov V. A. , Khokhlova M. N. , Strakhov M. A.
Published: July 2023

Musculoskeletal diseases, such as osteoarthritis (OA), nonspecific back pain (NBP), and periarticular soft tissue pathology (PSTP – tendinitis, enthesitis, bursitis, etc.) are one of the most common reasons for visiting general practitioners. The treatment of this pathology is based on the complex use of drugs and non-drug methods for maximum pain control and lost function restoration. Considering the common pathogenesis of musculoskeletal pain in OA, NBP, and PSTP, it is advisable to base the therapy of these diseases on a single algorithm. Of course, when prescribing treatment, one should take into account "red flags" (symptoms of life threatening diseases), features of the clinical course, patient's psycho-emotional condition, and comorbid diseases.

Development of a unified tactic for the treatment of musculoskeletal pain will significantly reduce the time spent on a diagnostic search and the choice of adequate therapy, which will facilitate the work of a general practitioner. Thus, non-drug approaches (patient education, kinesiotherapy, psychotherapeutic methods, etc.), non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic slow-acting drugs (SYSADOA) seem to be the most rational approach in the debut of the treatment of OA, NBP and PSTP. Among NSAIDs, celecoxib seems to be one of the optimal drugs in terms of efficacy and safety, and among SYSADOAs – diacerein. There is evidence that the combined use of these drugs may increase their analgesic and anti-inflammatory potential.
Association of TNFAIP3 (rs10499194) and TNF-α (rs1800629) gene polymorphisms with susceptibility to systemic lupus erythematosus with juvenile onset and its clinical phenotypes in the Russian pediatric population
Authors: Krylov M. Yu. , Kaleda M. I. , Samarkina E. Yu.
Published: July 2023

Numerous recent studies have shown that TNFAIP3 and TNF-α gene polymorphisms are associated with susceptibility to certain autoimmune and inflammatory diseases, including systemic lupus erythematosus (SLE), systemic scleroderma, rheumatoid arthritis, psoriasis, etc. However, the results of studies on associations between these polymorphisms and the risk of developing SLE in children are ambiguous and few in number.

Objective: to test the hypothesis of a possible association between the rs10499194 polymorphism of the TNFA1P3 gene and the rs1800629 polymorphism of the TNF-α gene with susceptibility to juvenile SLE (jSLE) and its clinical phenotypes in the Russian pediatric population.

Material and methods. Both polymorphisms were studied by allele-specific real-time polymerase chain reaction in 63 children (15 boys and 48 girls) with a confirmed diagnosis of jSLE, whose mean age was 12.3±3.2 years (3–17 years), and the mean duration of the disease was 4.1±2.4 years. Data on the frequency of genotypes and alleles of the corresponding TNFA1P3 and TNF-α gene polymorphisms in 309 healthy unrelated blood donors over the age of 18 years (20–45 years) were used as controls.

Results and discussion. The study showed that the frequency of the rs10499194T mutant allele of the TNFA1P3 gene in patients with jSLE was significantly lower compared to the control (20.6 and 30.7%; p=0.023), and its carriage slightly reduced the risk of developing SLE (odds ratio, OR 0.58; 95% confidence interval, CI 0.32–1.05, p=0.053). The frequency of the rs1800629A mutant allele of the TNF-α gene was slightly higher in jSLE compared with controls (38.1 and 26.2%, respectively; p=0.056), and its carriage slightly increased the risk of developing SLE (OR 1.73; 95% CI 0.93–3.16; p=0.056). An analysis of the frequency distribution of the rs10499194 genotypes in groups of patients with and without arthritis revealed significant differences (p=0.003). Carrying genotypes with the mutant T allele (CT+TT genotypes) in jSLE significantly reduced the risk of developing of arthritis (p=0.003). At the same time, the risk of arthritis in carriers of at least one C allele was 3.76 times higher than in carriers of the other allele (p=0.006). No relationship was found between the rs1800629 TNF-α gene polymorphism and the clinical phenotypes of jSLE.

Conclusion. The rs10499194T mutant allele statistically significant reduces the risk of arthritis development as one of the clinical manifestations of jSLE, and the rs1800629A mutant allele of the TNF-α gene is associated with a tendency to increase the risk of jSLE.
The role of trigger factors in the development of systemic sclerosis (clinical case)
Authors: Menshikova I. V. , Pak Y. V. , Petrukhnova M. F. , Mochalova O. I.
Published: July 2023

A clinical case of the development of rapidly progressive systemic sclerosis after repeated coronavirus infection is described. The contribution of occupational hazards, the oncological process and radiation therapy to the pathogenesis of this disease is discussed. Hydropericardium was a feature of the clinical picture, as well as rare immunological markers of the late onset of systemic sclerosis.
Simulation for formation process of atomic orbitals by the finite difference time domain method based on the eight-element Dirac equation
Authors: Mutoh Hideki
Published: July 2023

Using the finite difference time domain (FDTD) method based on the eight-element Dirac equation, we found that a stable Dirac field wave packet with low velocity can be created without explicit consideration of Zitterbewegung (the rapid oscillatory motion of elementary particles), which is difficult in one-dimensional simulations. Furthermore, we successfully simulated the formation process of atomic orbitals for the first time without any physical approximations by calculating the eight-element Dirac field propagation in the central electric force potential. Initially, a small unstable orbital appears, which rapidly grows and results in a large stable orbital with a radius equal to the Bohr radius divided by the atomic number, as given by the solution of the Schrödinger equation. The FDTD calculation based on the conventional four-element Dirac equation cannot produce such reasonable orbitals owing to the spatial asymmetry of the

4
×
4

4\times 4

Dirac matrices. This method has the potential to be used for transient analyses of not only atomic or molecular orbitals but also interactions among elementary particles.
Demographic and clinical factors associated with psychological wellbeing in people with chronic, non-specific musculoskeletal pain engaged in multimodal rehabilitation: –a cross-sectional study with a correlational design
Authors: Wiitavaara Birgitta , Rissén Dag , Nilsson Annika
Published: July 2023

Objectives

To investigate which demographic and clinical factors were associated with psychological wellbeing in working-aged people in multimodal rehabilitation for musculoskeletal disorders.

Methods

116 participants met the criteria for inclusion: persistent or intermittent pain for at least three months; pain that adversely impacts daily life; potential for active change despite pain; no co-morbidity or condition that will hinder participation in the rehabilitation program. Primary outcome was psychological wellbeing and independent measures were general, physical and mental health, pain intensity, limitations in daily life, depression and sleep.

Results

The results show decreased odds of psychological wellbeing for persons rating high on depression. The results remained significant after adjusting for sex and age. Being a woman increased the odds of high psychological wellbeing. Logistic regression showed that psychological wellbeing was not significantly associated with pain intensity; sleep; functional limitations; general, physical, or mental health. None of the other independent variables was significantly associated with high vs. low psychological wellbeing.

Conclusions

Depression turned out to be significantly related to psychological wellbeing, contrary to pain and limitations in daily life. If further studies with larger, random samples can confirm these results, this knowledge may be important both in clinical settings and in future research.
Analysis of resin and fatty acids enriched in papermaking process waters
Authors: Valto Piia , Knuutinen Juha , Alén Raimo , Rantalankila Mikko , Lehmonen Jani , Grönroos Antti , Houni Juha
Published: July 2023

The applicability of a special pilot-scale installation (Short Circulation Device) was studied for demonstrating the enrichment of selected resin and fatty acids in process waters when increasing water reuse during the manufacture of paper. The traditional gas chromatography with flame ionization detection (GC-FID), turbidity, and online sample enrichment (solid phase extraction, SPE) for atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) measurements were used for the analysis of the resin and fatty acids. The data from all the measurements with unbleached thermomechanical pulp (TMP) process waters were in a good agreement, and correlation coefficients (R2) > 0.9 were obtained in each case. Rapid information about the levels of wood extractives in papermaking process waters is of great importance, and it offers a suitable way to predict oncoming pitch problems. It was concluded that the routine control of the extractives level in papermaking process waters is possible by all these methods.
Problems of Legal Qualification and Application of Servitudes over Land for Building Use
Authors: Juzikienė Renata
Published: July 2023

The paper analyses the problems of legal qualification and practical application of servitude over land for building use. The doubts regarding the suitability of the servitude to resolve disputes between different owners of a plot of land and a building on it are raised. The reasonableness of the differences in the scope and compensation calculation of the servitude over land for use of the building determined on different grounds is analysed. Proposals for solving the problems raised in the article are made, the possibility of legal requalification and the legal consequences of it are analysed.
The use of the young schema questionnaire - long version (YSQ-L3): a systematic review of literature on interventions
Authors: Ferronatto Felipe Gonçalves , Anawate Muniz Tavares Maria Eduarda , Rospide Eduarda Baldissera , Borba Maria Eduarda , Valadão Leal João Antônio , Silva Oliveira Margareth da
Published: July 2023

chema Therapy is an approach that was initially used to treat personality disorders. However, over time, studies have shown that its use could also be extended to acute disorders. One way to investigate its effectiveness is by using the Young's Schema Questionnaire (YSQ), which investigates the Early Maladaptive Schemas (EMSs) of individuals. Through a Systematic Review of articles published from 2003 to 2019, this article proposes the investigation of interventions in Schema Therapy using the YSQ- Long Version (YSQ-L3). The bases investigated were SCOPUS, Pubmed and Psycinfo. Interventions were found in personality, mood and personality disorders. The studies were carried out both on individuals individually and in groups, but most of them were mixed. In all studies there was a decrease in psychopathological symptoms and EMSs. This denotes the importance of instrument validation studies and adaptation of protocols based on Schema Therapy for use in Brazil.
MICROMORPHOLOGICAL AND MORPHOSCOPIC PARAMETERS OF SAND GRAINS AS INTERPRETATION INDICATION OF THE GENESIS OF KINBURNSKA ARENA
Authors:   Volodymyr Vynnychenko Central Ukrainian State University, Kropyvnytskyi, Ukraine, Kryvulchenko A. S.
Published: July 2023

The Кіnburnska arena is one of the seven sand massifs of the Oleshkivsky Sands (Oleshia). In order to clarify the genesis of the relief forms of the Kinburngska аrena and in general the formation of the territory of the Oleshkivsky Sands, a map-scheme of the types of relief forms of the Kinburnska arena is presented for the first time. Another goal of this research was to find out the priority of fluvial or аeolian processes in the formation of arena landforms. In this regard, for the first time, micromorphological and morphoscopic studies of sand grains from deposits of hilly landforms were conducted here. The typology of landforms showed the geomorphological diversity of the arena and evidenced the manifestation of specific, here and there unique landforms. Unique for the territory of Europe here are discrete parallel ridges of the south of the arena, which are a manifestation of giant ripples (diluvial dunes). The author examines their formation in the context of the diluvial paradigm, in particular in relation to fluvioglacial processes at the end of the Pleistocene and flood-overflow processes in the Holocene. The specific formations of the arena here include ridges and depressions formed as a result of the flow of water masses from the water area of the Dniprovsko-Buzkyi liman to the Black Sea (western part of the arena), as well as its Yagorlytskyi Bay (eastern part of the arena). The analysis of the parameters of sand grains from the deposits of various geocomplexes of the Kinburnska arena showed the predominance of weakly rolled grains, as well as the dominance of bugor and bugor-stepped texture of the surface sand grains with almost universal development of micro- and nanoforms on their surface. The typology of the relief forms of the arena and the interpretation of the parameters of the analyzed sand grains proved the dominant role of fluvial processes in the formation of the relief of sandy deposits of the Kinburnska arena and the subordinate importance of aeolian processes.
Effect of Palmito cheese processing on sensory characteristics and degree of liking
Authors: Marín-Fonseca Andrea , Víquez-Barrantes Diana , Cordero-García Marcia
Published: July 2023

Introduction. The production of regional food with local and cultural identity has become an attractive business for small-scale producers because it allows them to market their products highlighting local ingredients and traditional processing that reflects the know-how of each region. One example is Pasta filata cheese. Objective. To identify sensory characteristics and level of liking for Costa Rican Pasta filata cheeses (Palmito cheese). Materials and methods. The project was carried out at the facilities of the University of Costa Rica, during 2015. Nineteen samples of Costa Rican Palmito cheese were used, with fourteen of them being produced by artisanal producers and five by industrial producers. The methodology of Generic Quantitative Descriptive Analysis (QDA) was followed, with ten trained judges defining twenty-one attributes. Agglomerative Hierarchical Clustering (AHC) and Principal Component Analysis (PCA) were conducted to relate the samples to their attributes. Acceptance testing was performed with one hundred consumers. Consumer AHC and external preference mapping were applied to correlate the results of the liking with those of the QDA. Results. Significant differences (p<0,05) among samples were obtained in the QDA for all attributes. The samples were grouped into three clusters based on similarity attributes. The PCA showed one group, primarily consisting of traditional cheeses, clustered by attributes such as acid and salty flavor, firmness, moisture, and stringy appearance. Another group, corresponding to refrigerated, pasteurized, and unpasteurized cheeses, had a higher intensity of yellow color, greasy texture, softness, and less stringy appearance. A final group, composed of one sample, had a lettuce flavor. Conclusion. Through the external preference mapping, it was concluded that consumers like the majority of industrial Palmito cheeses, but they prefer traditional ones with characteristics such as stringy and creamy flavor.
Inconsistencia e interpretaciones en falacias referenciando los transmétodos decoloniales planetarios-complejos
Authors: Rodriguez Milagros Elena
Published: July 2023

Se analizan algunas inconsistencias e interpretaciones en falacias ocurridas referenciando los transmétodos decoloniales planetarios-complejos en algunas investigaciones. Aprovechamos el transmétodo la deconstrucción rizomática que abre un abanico de posibilidades en la indagación. Se evidencian posturas y errados uso de los transmétodos en la pesquisa de algunos autores; una forzada relacionalidad. La reconstrucción pone en escena la utilización en un número considerable de investigadores del legado transmetódico decolonial planetario-complejo. La decolonialidad planetaria y así los transmétodos no denigran persona alguna su acogida es planetaria, se promueve con ellos la solidaridad, el amor por la humanidad; como en las Sagradas Escrituras.
Cybernetyka a deformacja demokracji
Authors: Sala Jolanta , Tańska Halina
Published: July 2023

Artykuł wskazuje możliwości wypracowania podejścia stosującego potencjał cybernetyki do modelowania procesów społeczno-ekonomicznych i politycznych w celu interdyscyplinarnej dyskusji dotyczącej współczesnych kryzysów w kontekście nierówności społecznych i wzrostu gospodarczego. Wybrany został interdyscyplinarny dorobek nauk politologicznych, społecznych i ekonomicznych, który umożliwia podjęcie badania zjawisk i procesów społeczno-gospodarczych oraz uzyskanie wyników o znakomitej zgodności z rzeczywistością zachowując minimalizujący wpływ subiektywnej interpretacji.Do próby modelowania rzeczywistości wyabstrahowano procesy deformacji demokratycznego państwa, która jest atrakcyjnym tematem dyskusji i publikacji kolejnych pokoleń od czasów Arystotelesa. Założono za N. Urbinati, iż współcześnie cywilizacyjne znaczenie poznawcze tych procesów świadczy o respektowaniu społecznego instynktu samozachowawczego, a w konsekwencjio konieczności podniesienia rangi obiektywizmu. Inspirujące modele opisowe N. Urbinati stanowią podstawę systemowego wyabstrahowania badanego okresu przebiegu procesów demokratycznych od kryzysów powstałych w XIX wieku w wyniku pierwszej rewolucji przemysłowej, poprzez dwie wojny światowe w XX wieku w kontekście międzynarodowych ustaleń po ich zakończeniu, poprzez powrót do demokracji w Polsce po zmianach ustrojowych od lat dziewięćdziesiątych XX wieku, do obecnie trwającej czwartej rewolucji przemysłowej zwanej Przemysł 4.0 (ang. Industry 4.0).Artykuł nie stanowi systematycznej prezentacji uzyskanych szczegółowych wyników, gdyż przywołane zostały tylko te najbardziej spektakularne zjawiska świadczące o różnych deformacjach, wynaturzeniach lub transformacjach demokracji (w praktyce lub teorii) w kontekście metodycznym. Wykorzystany został dorobek metodyczny cybernetyki społecznej, cybernetyki ekonomicznej, a także informatyki i ekonomiki informacji. Przyjęto pragmatyczną skuteczność koncepcyjnej perspektywy systemu sztucznej inteligencji (AI) na najwyższym poziomie abstrakcji.
Branża wypożyczalni samochodów w dobie pandemii COVID-19 – pragmatyzm w zarządzaniu
Authors: Gierczak-Korzeniowska Beata
Published: July 2023

Celem artykułu jest identyfikacja inicjatyw oraz rozwiązań stosowanych przez wypożyczalnie samochodów w czasie pandemii COVID-19. Prezentowane w tekście analizy dotyczą wyników badania przeprowadzonego w agencjach wynajmu samochodów zlokalizowanych w Porcie Lotniczym im. Václava Havla w Pradze. W części teoretycznej przeprowadzono kwerendę literatury, natomiast do opracowania części empirycznej wykorzystano kwestionariusz ankiety. Przeprowadzone badania pokazały, że wybuch pandemii COVID-19 w istotny sposób zahamował i ograniczył rozwój oraz funkcjonowanie branży wypożyczalni samochodów. W badanych agencjach odnotowano 50% spadek liczby zamówień. Straty doprowadziły do ograniczania kosztów, które przełożyły się na zwolnienia lub zmiany umów z pracownikami. Dokonano zbycia aktywów niezwiązanych z podstawową działalnością firmy oraz podjęto współpracę z innymi podmiotami, aby zdywersyfikować źródła dochodu i potencjalnych klientów w czasie obostrzeń pandemicznych. Istotnej zmianie uległa także kategoria klienta wypożyczalni samochodów, a co za tym idzie, modele mobilności podróżnych korzystających z usług wypożyczalni samochodów. Pojawiły się wydatki na bezpieczeństwo i ochronę zdrowia pracowników i klientów, które stanowiły dodatkowe obciążenie dla przedsiębiorstw. Wyniki badań mogą stanowić źródło informacji dla agencji, które w przyszłości mogą być narażone na podobne i trudne sytuacje.
ADOÇÃO POR CASAIS HOMOAFETIVOS
Authors: Biasibetti Francielli , Crippa Anelise
Published: July 2023

O presente trabalho tem por escopo abordar a possibilidade da adoção por casais homoafetivos como um surgimento de uma nova família. Através de questões abordadas pela doutrina brasileira, com base e fundamentos nos preceitos previstos na Constituição Federal de 1988, leis ordinárias e análise jurisprudencial. Nos últimos anos o conceito de família passou por diversas mudanças e avanços, assim, veio o surgimento do termo pluralismo familiar. Consigo, houve o reconhecimento da existência de outras estruturas familiares modificando o entendimento de que família era apenas aquela constituída através do matrimônio. Necessário e relevante aprender as conquistas referentes ao conhecimento da união estável e do casamento entre pessoas do mesmo sexo, tendo em vista que esse reconhecimento possibilitou a esses casais pleitear a adoção conjunta. A adoção traz consigo a possibilidade de crianças que vivem em casas de apoio, descrentes de serem adotadas, terem a possibilidade de formar uma família. Devem-se destacar inúmeras situações de crianças e adolescentes em nosso país a espera de um lar, e por esse motivo a adoção deve ser divulgada, incentivada, e tratada como um ato de amor e comprometimento com o próximo. A adoção homoafetiva ainda não possui um amparo na legislação vigente, apenas tem entendimentos e julgados tratando sobre o tema. Desse modo, abrem margem para diversas polêmicas e discussões em função desse assunto, seja no âmbito jurídico como também no âmbito social. A união entre casais do mesmo sexo vem aumentando gradativamente e segundo a legislação brasileira não há nenhum impedimento quanto à adoção por parte desses casais. Importante, no entanto, que o judiciário, a sociedade e demais envolvidos levem sempre em consideração o interesse da criança e o adolescente, dos quais necessitam de um lar e de afeto, e que a mera opção sexual do indivíduo jamais seja ferida pelo julgamento equivocado e preconceituoso.
Competencia en cuidado espiritual en enfermería: Revisión integrativa de literatura
Authors: Torres Contreras Claudia Consuelo , Vargas Escobar Lina María , Triana Rodríguez Jorge Yecid , Cañon-Montañez Wilson
Published: July 2023

Introducción: El cuidado espiritual puede considerarse un elemento central de la filosofía del cuidado holístico. Objetivo: Identificar investigaciones de intervención con perspectivas y estrategias educativas para el desarrollo de competencias en cuidado espiritual. Materiales y métodos: Revisión de la literatura en el período 2001-2021 de las bases de datos PubMed, ProQuest, Scopus, Lilacs y BVS (Biblioteca Virtual en Salud). Se siguieron las recomendaciones PRISMA y se basaron en parámetros definidos por Whittemore y Knafl para la identificación de problemas, búsqueda bibliográfica, evaluación y análisis de datos. Resultados: se encontraron 10 artículos de intervención publicados. Los entrenamientos relacionados con el desarrollo de habilidades para el cuidado espiritual fueron realizados en programas de formación superior del personal de enfermería. Las estrategias de instrucción son cursos específicos, sesiones cortas o programas a lo largo del plan de estudios. Las intervenciones muestran efectos sobre las habilidades y conocimientos. La espiritualidad individual de los estudiantes predice la capacidad de brindar atención espiritual. Conclusiones: Hay evidencia de estrategias para desarrollar la competencia de estudiantes y profesionales de enfermería en cuidado espiritual, aún son escasas las publicaciones sobre el tema, por lo que se necesitan nuevas y más rigurosas estrategias para desarrollar competencia en este enfoque de la disciplina de enfermería.
Prognostic significance of NT-proBNP and sST2 biomarkers in patients with post-myocardial infarction heart failure after a coronavirus infection
Authors: Kalashnikova N. M. , Zaitsev D. N. , Govorin A. V. , Chistyakova M. V. , Balzhitov B. T.
Published: July 2023

Aim. To determine the prognostic significance of N-terminal pro-brain natriuretic peptide (NT-proBNP) and soluble ST2 (sST2) in patients with post-myocardial infarction heart failure after a coronavirus disease 2019 (COVID-19)

Material and methods. Three following groups were formed: in patients of group I (main), who underwent inpatient treatment for COVID-19, the cause of heart failure (HF) was prior Q-wave myocardial infarction; in patients of group II (comparison) without COVID-19, the cause of HF was prior Q-wave myocardial infarction; Group III (comparison) — patients with HF of ischemic origin without postinfarction cardiosclerosis and COVID-19. Statistical processing was carried out using the software package IBM SPSS Statistics Version 26.0.

Results. The patients of all three groups included in the present study were comparable. After 6 months in group I, HF course worsening was recorded. In patients of groups I and II, an increase in NYHA HF class from 2 to 3 and 4 was recorded, in contrast to patients of group III, among whom the number of patients with class 3 HF decreased by 25% due to compensation to class 2. Patients of the studied groups, who had elevated serum levels of NT-proBNP and sST2, had more pronounced structural and functional myocardial disorders than patients with normal levels of these biomarkers. Using analysis of adverse cardiovascular events, such as recurrent myocardial infarction, cerebrovascular accident, hospitalization due to coronary artery disease, decompensated HF, which required hospitalization, a predictive model was developed using a neural network. There were following most important factors of the developed model: age, level of NT-proBNP and sST2, lung involvement according to computed tomography.

Conclusion. Modern biomarkers NT-proBNP and sST2 have sufficient predictive value to determine the risk of adverse events in HF.
Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography
Authors: Ilov N. N. , Stompel D. R. , Boytsov S. A. , Palnikova O. V. , Nechepurenko A. A.
Published: July 2023

Aim. To study the mortality rate of acute decompensated heart failure (ADHF) in patients with heart failure with reduced ejection fraction (HFrEF) within a year after implantation of cardioverter-defibrillator (ICD), to evaluate the potential of its prediction using transthoracic echocardiography.

Material and methods. The study included 384 patients with NYHA class 3-4 heart failure with left ventricular ejection fraction (LVEF) ≤35%, who were scheduled for ICD implantation for the primary prevention of sudden cardiac death (SCD). After ICD implantation, enrolled patients were followed up for a year to record the primary endpoint of death due to ADHF.

Results. During the 1-year follow-up, the primary endpoint was recorded in 38 patients (10%). A univariate logistic regression identified 14 echocardiographic parameters with the highest predictive potential (p<0,1) associated with the studied endpoint. Based on multivariate regression analysis, a prognostic model was developed, which included three factors with the highest statistical significance: LVEF, right atrial (RA) medial-lateral size, and pulmonary artery systolic pressure. The diagnostic efficiency of the model was 78,7% (sensitivity, 82,4%; specificity, 78,3%). A decrease in LVEF ≤28% and an increase in (RA) medial-lateral size ≥3,9 cm were found to be independent predictors of the studied endpoint.

Conclusion. Approximately 10% of HFrEF patients selected for ICD implantation for primary prevention of SCD die due to ADHF during the 1-year follow-up. Transthoracic echocardiography has potential to predict this outcome.
Right ventricular dysfunction as a predictor of complicated course in left heart surgery
Authors: Golukhova E. Z. , Slivneva I. V. , Skopin I. I. , Farulova I. Yu. , Pirushkina Yu. D. , Murysova D. V. , Marapov D. I. , Volkovskaya I. V.
Published: July 2023

Aim. To analyze the right ventricular (RV) functionality in a cohort of heterogeneous cardiac surgical patients with left-sided valvular heart disease and determine the contribution of RV dysfunction in the complicated postoperative period according to echocardiography.

Material and methods. A single-center prospective study of patients with left heart defects operated on in 2022 was conducted. Age ranged was 20-81 years, with a median age of 58 years. The study was conducted on a PHILIPS EPIQ CVx system using an X5-1 probe.

Results. To estimate the risk of a complicated postoperative period depending on various indicators of RV systolic function assessment, ROC-analysis was performed. The ROC curve of the RV free wall longitudinal strain (RV FW LS) was characterized by the highest AUC value among other RV functional measures, equal to 0,81±0,06 (95% confidence interval (CI): 0,68-0,93), p<0,001. A value of 20% was selected as the cut-off point of RV FW LS for predicting a complicated postoperative period. The RV FW LS <20% was 19,2 times more likely to develop a complicated course (95% CI: 5,64 to 65,50), compared with the RV FW LS group ≥20%; p<0,05. The odds of heart failure (HF) in the RV FW LS <20% group were 22,78 times higher (95% CI: 5,90 to 88,04), compared with the RV FW LS ≥20% group; p<0,05.

Conclusion. The RV FW LS <20% can be considered an independent predictor of complicated postoperative period with a multiple increase in the risk of complications, mainly the risk of heart failure. The assessment of RV FW LS can significantly help in risk stratification, being the reason for the reclassification of a number of patients in the high-risk group with a possible modification of surgical strategy.
Prediction of in-hospital mortality in patients with ST-segment elevation acute myocardial infarction after percutaneous coronary intervention
Authors: Geltser B. I. , Shahgeldyan K. I. , Domzhalov I. G. , Kuksin N. S. , Kokarev E. A. , Kotelnikov V. N. , Rublev V. Yu.
Published: July 2023

Aim. Development of models for predicting in-hospital mortality (IHM) in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) based on multivariate logistic regression (MLR).

Material and methods. This retrospective cohort study of 4735 electronic health records of patients (3249 men and 1486 women) with STEMI aged 26 to 93 years with a median of 63 years who underwent PCI was performed. Two groups of persons were identified, the first of which consisted of 321 (6,8%) patients who died in the hospital, while the second — 4413 (93,2%) patients with a favorable PCI outcome. To develop predictive models, univariate logistic regression (ULR) and MLR were used. Model accuracy was assessed using 3 following metrics: area under the ROC curve (AUC), sensitivity, and specificity. The end point was represented by the IHM score in STEMI patients after PCI.

Results. Statistical analysis made it possible to identify factors that are linearly associated with IHM. ULR was used to determine their weight coefficients characterizing the predictive potential. IHM predictive algorithms based on GRACE scale predictors, represented both by ULR model and by 5 factors in continuous MLR model, had acceptable predictive accuracy (AUC — 0,83 and 0,86, respectively). The MLR model had the best quality metrics, the structure of which, in addition to 5 GRACE factors, included left ventricular ejection fraction (LVEF) parameters and white blood cell (WBC) count (AUC — 0,93, sensitivity — 0,87, specificity — 0,86) . The greatest contribution to endpoint was associated with the Killip class and LVEF, and the smallest contribution was associated with WBC and the age of patients.

Conclusion. The predictive accuracy of the developed MLR models was higher than that of the GRACE score. The model with the structure represented by 5 fac­tors GRACE, LV EF and WBC had the highest quality metrics.
Clinical and economic analysis of empagliflozin therapy in patients with heart failure across the ejection fraction range
Authors: Nedogoda S. V. , Salasyuk A. S. , Barykina I. N. , Lutova V. O. , Popova E. A.
Published: July 2023

Aim. To evaluate the cost-effectiveness of empagliflozin therapy in patients with heart failure (HF) across the ejection fraction (EF) range in the Russian Fe­­deration.

Material and methods. An analysis of the cost of HF management was carried out and an analytical decision-making model was built in MS Excel, which makes it possible estimating the costs of HF management with empagliflozin from the state position.

Results. Taking into account the direct costs of adverse events, as well as indirect costs, the potential economic benefit of empagliflozin use for 766028 HF patients with low EF could be RUB 7,6-7,8 billion per year of therapy, while for 5790280 patients with HF with moderately reduced and preserved EF — RUB 27,6-29,6 billion per year of therapy. The potential economic benefit of empagliflozin for 664960 patients with HF immediately after hospitalization for an HF exacerbation could be RUB 1,4-1,6 billion per year of therapy, allowing to prevent 69438 deaths and 60822 repeated exacerbations of HF.

Conclusion. Empagliflozin is the optimal regimen for the treatment of patients with HF across the entire EF range, both with and without type 2 diabetes, both in terms of clinical efficacy of treatment and economic feasibility.
Systematic review of training methods for conversational systems: the potential of datasets validated with user experience
Authors: Abrantes Carolina , Camargo Juliana , Nunes José , Antunes Maria João , Mealha Óscar , Nóbrega Luís
Published: July 2023

The increasing maturity of artificial intelligence technologies such as Machine Learning algorithms, Natural Language Processing (NLP), Automatic Speech Recognition (ASR) and Natural Language generation are changing the way users interact with technology. Specifically, as voice interactions are becoming commonplace, it is important to understand how such systems are being trained. This systematic review investigates how human data is collected for training conversational agents, with specific interest on data sets directly obtained from human participation in real contexts of need and use. The work reported in this article was supported by PRISMA guidelines and search procedures were led in Scopus, Web of Science and ProQuest, in English and within the last 15-years (2005-2020), with pre-defined criteria to get a detailed holistic perspective of practices published until July 2020. From both search iterations, a total of 22 papers were considered for this review. The main contributions from these papers reveal a common use of learning from demonstration/observation and crowdsourcing methods, in system training and dataset cataloguing, alongside handwriting and sentence labelling and Wizard-of-Oz based studies.
Humidophila davydovae (Bacillariophyta), a New Diatom Species to Science
Authors: Genkal S. I. , Gabyshev V. A.
Published: July 2023

The study of algological material, from tundra lakes adjacent to the territories in the Ust-Lena Reserve (Yakutia, Russia), using a scanning electron microscopy revealed a new diatom species to science, Humidophila davydovae sp. nov. The new species has morphological similarities with other species of the genus, H. schmassmannii, but differs in shape of the valve and the central field, leaf length, width, and the number of striae.
Análisis de la estructura factorial del desafío bebras 2021 en Uruguay y resultados preliminares
Authors: Urruticoechea Alar , Oliveri Andrés , Koleszar Victor
Published: July 2023

Hoy en día la tecnología forma parte de la mayoría de las actividades cotidianas personales. En el ámbito educativo, concretamente, las herramientas tecnológicas son utilizadas como facilitadoras del aprendizaje. Esto, junto a la necesidad de facilitar herramientas variadas para formar a los estudiantes, generando, en muchos países, un cambio del paradigma educativo, pasando de una educación contenidista a una educación por competencias. Por ello el PC ha ganado relevancia a nivel internacional. El Pensamiento Computacional refiere al conjunto de competencias para la expresión y resolución de problemas utilizando la lógica de la programación. En el ámbito educativo la adquisición de estas competencias permitirá a los niños hacer frente a un futuro cada vez más tecnológico. Para conocer el estado de adquisición de estas competencias es necesario tener instrumentos de medida validados. Esta investigación pretende verificar la estructura teórica del desafío Bebras aplicado en Uruguay durante 2021 y a partir de esta realizar un análisis preliminar de la situación. Para ello, a las respuestas de 20,393 participantes en Bebras de 5° y 6° de Educación Pública, se le aplicó un Análisis Factorial Confirmatorio, Pruebas T de Student y ANOVAs. Los principales resultados obtenidos son: La estructura factorial coincide con la definición teórica de cada ítem. Existen diferencias estadísticamente significativas por género (p.valor < .05), grado (p.valor <.01) y nivel sociocultural (F(5, 2730) = 42 ; p.valor <.00). Se puede concluir que existe una estructura factorial que se asemeja a la teórica, esto contradice a las investigaciones que afirman que Bebras no posee la estructura factorial, y que los resultados del análisis de los factores concuerdan con las investigaciones que analizan tanto las diferencias de rendimiento por género como por nivel sociocultural.
Resiliencia académica en la enseñanza superior: un estudio de caso
Authors: Dobrianskyj Weber Lidia Natalia , Angst Pasqualotto Rosana
Published: July 2023

La resiliencia es la capacidad de una persona, grupo o comunidad para atravesar adversidades, superarlas a pesar de las dificultades encontradas y ser capaz de crecer con ellas. En la enseñanza superior, muchos estudiantes tienen dificultades económicas, dificultades para conciliar trabajo y estudios, son incapaces de comprender los contenidos, además de los problemas familiares que pueden surgir, lo que puede provocar que abandonen el curso que eligieron. La resiliencia académica se define como la capacidad de atravesar las dificultades encontradas en el entorno educativo y superarlas, permitiendo a la persona crecer como resultado de esta situación adversa. Este estudio tuvo como objetivo analizar aspectos relacionados con la resiliencia académica de un estudiante de licenciatura en Física de una universidad pública brasileña que participó en esta investigación. Para mantener el anonimato, se le pidió al estudiante que nombrara una figura importante en su campo, y así se hizo llamar Einstein. Einstein afirmó que encuentra muchas dificultades en la enseñanza superior: falta de apoyo familiar para cursar una carrera universitaria, falta de tiempo para dedicarse al estudio porque necesita trabajar, asignaturas suspendidas que retrasan su graduación y falta de tiempo con su familia. A pesar de estos obstáculos, tiene la intención de terminar el curso para tener una vida mejor que la que cree que tiene hoy. Ha demostrado perseverancia, y el apoyo tanto de profesores como de familiares le impulsa a perseguir su sueño de graduarse. Este es un caso de resiliencia académica, porque a pesar de las adversidades
Atividade física infantil em tempo de pandemia(s): uma ponte para intervenções mais significativas
Authors: Condessa Isabel
Published: July 2023

Nesta comunicação, propomo-nos refletir as alterações educativas a promover tendo em vista o combate de múltiplas pandemias, com impacto na quantidade e qualidade de movimento das crianças da atualidade. Se nos últimos anos, perante a inesperada situação pandémica da COVID – 19, houve adaptações às práticas suportando-se uma educação mais orientada para o indivíduo, com este período cresceram os índices de conforto que se refletiram no aumento de tempo em écran, isolamento social e obesidade. Na escola ou em casa, os profissionais da educação e familiares tem agora que repensar práticas intencionais e significativas, ajustadas às necessidades de novas conquistas de desenvolvimento e aprendizagem - capacidades físicas e motoras, competências específicas de desporto, mas também, socio emocionais. É urgente uma mudança de atitudes para a melhoria de qualidade de vida e bem-estar infantil, preparando a sociedade para uma consciencialização crescente da relevância da Atividade Física, no combate aos comportamentos de adição e ao tempo de sedentarismo. Pretendemos abordaras práticas e reflexões de educadores que, nos últimos 10 anos,em contexto de estágio pedagógico efetuado numa mesma instituição de ensino superior, dedicaram parte da sua intervenção educativa apelando à prática de atividades de movimento significativas para crianças, a maioria, em interdisciplinaridade. Corroboramos aqui, uma perspetiva de formação profissional do educador orientada para a compreensão da importância da prática física – lúdica ou desportiva, numa educação da criança que seja equilibrada, multidimensional, ativa, inclusiva e interativa; e isto, sem nunca esquecer os seus direitos. Este será um verdadeiro contributo para uma educação infantil mais ativa e orientada para uma melhor saúde e bem-estar.
Estudio exploratorio sobre maltrato infantil, regulación emocional y autoestima en una muestra de adolescentes en medidas judiciales
Authors: García Montoliu Carlos , Andreu Casas Marina , Giménez García Cristina , Gil Llario Mª Dolores , Ballester Arnal Rafael
Published: July 2023

La literatura científica recoge un amplio número de investigaciones que destacan el impacto del maltrato infantil, incluyendo el abuso sexual infantil (ASI), sobre la salud mental. Sin embargo, los estudios que exploran y relacionan estas variables en muestras de adolescentes en medidas judiciales todavía son escasos. Por ello, el objetivo principal de esta investigación fue analizar la prevalencia del maltrato infantil en la historia de vida de estos adolescentes, las diferencias de género en diferentes tipos de maltrato y la posible relación entre el maltrato infantil, la regulación emocional y la autoestima. Se administró la adaptación de la Child Abuse and Trauma scale (CAT), la subescala de abuso sexual del Juvenile Victimization Questionnaire (JVQ), la Escala de Dificultades en la Regulación Emocional (DERS) y la escala de Autoestima de Rosenberg (RSE) a 30 adolescentes (22 hombres y 8 mujeres) de entre 15 y 17 años (M=16,33; DT=0,76) de una residencia socioeducativa de Castellón (España). En el caso del CAT, solo se encontraron diferencias de género estadísticamente significativas en el ítem de experiencias sexuales traumáticas pasadas (U=49; p=.009). Las mujeres informaron de más experiencias de este tipo. Sin embargo, en el JVQ no se encontraron diferencias en este sentido. Un 20% de adolescentes informó haber sido víctima de ASI, el 13,6% de los hombres y el 37,5% de las mujeres. Por lo que respecta a la relación entre las variables, se encontró una asociación estadísticamente significativa con signo negativo entre la regulación emocional y la autoestima (r=-.599; p=.009). Conocer en profundidad la relación entre las experiencias de maltrato en la infancia y el desarrollo de problemas de salud mental en adolescentes que han cometido un delito podría ser útil para desarrollar estrategias dirigidas no solo a la reducción de la reincidencia, sino a la mejora de la salud mental de este colectivo.