bluuebunny/crossref_metadata_2025 huggingface dataset:
Jinekolojik endokaviter brakiterapi uygulamalarında bilgisayarlı planlama ve TLD dozimetrisi ölçümlerinin karşılaştırılması
Authors: Olacak Nezahat , Özsaran Zeynep
Published: June 2024

Amaç: Opere/inopere serviks ve endometrium kanserli hastaların endokaviter brakiterapi tedavisinde rektum ve mesane dozlarının dozimetrik değerlendirilmesidir.
Gereç ve Yöntem:10 inopere, 12 opere serviks ve endometrium kanserli hastaların endokaviter brakiterapi tedavilerinde rektumdaki dozları ölçmek için, thermolüminisans dozimetre (TLD) içeren rektal prob yerleştirildi. Mesane dozlarını belirlemek için mesane boynuna foley sonda (balon) ve tabanına bir zincir yerleştirildi. Hastaların simülatörde çekilen radyografileri üzerinde aplikatör noktaları, vajen, mesane ve rektum noktaları belirlenip brakiterapi tedavi planlama sisteminde doz dağılımları hesaplatıldı. Rektumda 4 noktada hesaplanan ve TLD ile ölçülen dozlar yüzde fark olarak karşılaştırıldı. Mesane boynundaki doz, tabanındaki en yüksek doz ile istatistiksel olarak karşılaştırıldı.
Bulgular: Rektum için, opere ve inopere hastalarda iki teknik arasındaki farklar; sırasıyla, maksimum %17,68 ve %17,96, minimum %0,38 ve %0,20, ortalama R1: %5,62, R2: %4,22, R3: %5,96, R4: %7,58 ve R1: %6,73, R2: %4,36, R3: %4,34, R4: %7,53 olarak belirlendi. Mesane boynu ile tabanındaki maksimum doz noktası arasındaki fark opere hastalarda anlamlı (p=0,0037) iken, inopere hastalarda anlamsız bulundu (p=0,3863).
Sonuç: Rektumda hesaplanan ile ölçülen dozlar arasındaki fark klinik açıdan önemli değildir. Rektal komplikasyonlar için dozlar birçok noktada belirlenmelidir. Mesane boynunda belirlenen doz mesane komplikasyonları için yeterli değildir, mesane tabanında da dozlar belirlenmelidir.
Two fighters against oxidative stress in peripheral organs in Parkinson's Disease: Brain-derived neurotrophic factor and hydrogen sulfide
Authors: Tezcan Yavuz Berna , Şirin Cansın , Tomruk Canberk , Hacıoğlu Gulay , Cırrık Selma , Güleç Peker Emine Gülçeri , Takır Selçuk
Published: June 2024

Aim: Parkinson's disease, which is a neurodegenerative disorder, has adverse consequences on peripheral organs as well as the brain. This study aims to investigate the effects of brain-derived neurotrophic factor and hydrogen sulfide on liver, kidney, stomach and intestine in Parkinson's disease model created in mice. Materials and Methods: To assess the achievement of the Parkinson's disease model and the effects of brain-derived neurotrophic factor and hydrogen sulfide on this model, animals in all groups were subjected to motor behavior tests. Oxidative stress in peripheral organs was determined biochemically by measuring total oxidant and total antioxidant levels. It was also evaluated histologically in terms of tissue damage and cellular degeneration. Results: According to the motor behaviour tests it was revealed that hydrogen sulfide increased motor performance and coordination against Parkinson's disease and decreased bradykinesia. Experimental Parkinson's Disease and inhibition of the brain-derived neurotrophic factor caused cellular changes in the liver, kidney, and intestine indicating oxidative stress-induced degeneration. It was revealed that hydrogen sulfide protects the histological structure especially in the liver and intestinal tissue and supports the process by increasing the antioxidant capacity in the liver and decreasing the oxidant capacity in the intestine. Conclusion: Brain-derived neurotrophic factor and hydrogen sulfide have different but generaly protective effects on oxidative stress in peripheral organs due to Parkinson's disease.
The effect of Glycyrrhiza glabra extracts on inhibiton of 3Clpro
Authors: Canbay Erhan , Kocamanoğlu Meltem , Fedacı Cemrehan , Çopur Öznur , Ünlü Murat , Akçay Yasemin , Y. Sözmen Eser
Published: June 2024

The Sars-CoV-2 virus causes the COVID-19 disease, which is characterized by high mortality rate and symptoms such as severe acute respiratory failure. However, it has been proven that the 3-chymotrypsin-like protease (3Clpro) enzyme, which plays a key role in the replication of the Sars-CoV-2 virus, can be inhibited by certain natural compounds with a flavonoid structure. Flavonoids interact with the active site of the enzyme, resulting in enzyme inhibition. In this project, the aim was to determine the inhibitory concentrations of flavonoid molecules on 3Clpro and obtain the most effective extracts of licorice root (Glycyrrhiza Glabra L.), which is known to contain high levels of these molecules. The goal of our project is to investigate the effects of extracts obtained from licorice root using different extraction methods on the inhibition of the 3Clpro enzyme and their potential role in the treatment of Sars-CoV-2 virus infection. In our study, the phenolic content of these natural products was determined for the first time using LC MS/MS, and the inhibitory effect of these natural product extracts on the 3Clpro enzyme was also studied for the first time. When licorice root extracts were evaluated in terms of antioxidant parameters, the highest TEAC, FRAP, and DPPH levels were observed particularly in ethanol extracts. The extracts that showed the highest inhibition effect for the 3-CLpro enzyme of licorice root were respectively obtained by soaking at 80°C for 6 hours, soaking in an ultrasound bath for 20 minutes, soaking in water at 40°C for 24 hours, soaking in 60% ethanol, and soaking in 80% ethanol. The most studied bioactive compounds of licorice root in the literature are glycyrrhizin, glycyrrhetinic acid, isoliquiritin, and isoflavones. However, in this study, the phenolic acid and flavonoid content, which are not widely covered in the literature, were also examined. Among the compounds studied in licorice root, the most abundant compounds were found to be apigenin, pelargonin, cyanidin, maleic acid, ethyl ferulate, and chlorogenic acid
Palyatif Bakım Ünitesinde Ölüm Sürecindeki Müdahale ve Bakımda Hemşireleri Etkileyen Faktörler: Fenomenolojik Çalışma
Authors: Demirci Güngördü Nuray , Akbal Yağmur , Üstün Çağatay , Başaran Ayşe
Published: June 2024

Amaç: Bu araştırmada, palyatif bakım ünitesinde görev yapan hemşirelerin ölüm sürecindeki bakımında müdahale ve bakımlarını etkileyen faktörler değerlendirildi.
Gereç ve Yöntem: Araştırmanın çalışma grubunu bir eğitim ve araştırma hastanesinin palyatif bakım ünitesinde görev yapan ve araştırmaya katılmayı kabul eden 22 hemşire oluşturdu. Araştırma, Mart 2017- Ağustos 2017 tarihleri arasında yapıldı ve nitel fenomenolojik yöntem kullanıldı. Veriler araştırmacılar tarafından hazırlanan “Bilgi Formu” ve “Yarı Yapılandırılmış Soru Formu” ile toplandı. Verilerin değerlendirilmesinde içerik analizi yöntemi kullanıldı.
Bulgular: Araştırmaya katılan hemşirelerin yaş ortalaması 33.05±7.20 olup, %77.3’ü kadındı. Palyatif bakım ünitesinde çalışma süreleri (ay) 37.2±18.8’di. Üç tema elde edildi. Bunlar “ölüme bakış açısının değişmesi”, “ölüm anındaki müdahale ve bakım sürecinde hemşirelere hasta yakınları tarafından çıkarılan zorluklar” ve “palyatif bakım ünitesindeki mevcut yapılandırmada yaşanılan sorunlar”.
Sonuç: Palyatif bakım ünitesinde çalışan hemşirelerin ölüm sürecine ilişkin görüşlerinin değiştiği ve müdahalelerde değişen koşulların sorunlar oluşturduğu tespit edildi.
Ege Üniversitesi Tıp Fakültesi Öğrencilerinde Çölyak Hastalığı Taraması Ve Çölyak Farkındalığı Çalışması
Authors: Ergün Pelin , Yarar Kenan Yigit , Sertoz Ruchan , Bor Serhat
Published: June 2024

Amaç: Dünya genelinde yaklaşık %1’lik bir prevelansa sahip olan çölyak hastalığı, ülkemizde de sık görülmekte ancak tanıda gözden kaçabilmektedir. Asemptomatik çölyak hastalığının yetişkin bireylerde daha sık görülmesi de tanıyı zorlaştırmaktadır. Bu nedenle çölyak hastalığının farkındalığını arttırmak ve hastalığının farkında olmayan bireylerin tanı almasını sağlamak amacıyla Ege Üniversitesi Tıp Fakültesi bünyesinde bir anket ve bilgilendirme çalışması düzenlenmiştir.
Gereç ve Yöntem: Çalışmamızda yaklaşık 550 tıp fakültesi öğrencisine ayrıntılı çölyak semptom anketi uygulanmış ve semptom pozitifliği belirlenen 110 birey Ege Üniversitesi Tıp Fakültesi Gastroenteroloji Kliniği’ne davet edilmiştir.
Bulgular: Davetler sonucunda yalnızca 36 kişi kliniğimize ziyaret gerçekleştirmiştir. Bu ziyaretler esnasında hastaların anemnezleri sonrası serumlarında çölyak antikorları incelenmiştir. Çalışma sonucunda çölyak ilişkili klinik bulgular ve riskler göstermelerine rağmen hiçbir hastada çölyak serolojisine rastlanmamıştır. Bu kişilerin ilerleyen dönemlerde semptom pozitifliği devam etmesi durumunda tekrar kliniğe davet edilmeleri planlanmıştır. Ayrıca bu kişilerin çölyak dışı gluten intoleranslarının olabileceği düşünülmüştür.
Sonuç: Ülkemizde tıp fakültesi öğrencileri arasında ilk defa gerçekleştirilen çölyak semptom taraması çalışmasının, ilerleyen dönemlerde merkez kampüs kapsamında genişletilerek tekrarlanması planlanmaktadır. Bunların dışında, yapılan bu çalışma ile tıp fakültesi öğrencilerinin sahip olduğu birçok hastalık ve tıbbi şikâyetin sıklıklarına yönelik veriler elde edilmiştir.
Restless Limbs and Bladder: An Atypical Variant of Restless Legs Syndrome Case Report
Authors: Kılboz Bekir Burak , Tıraş Raziye
Published: June 2024

Restless Legs Syndrome (RLS) primarily affects the legs, but atypical variants involving other body parts have been described. We present a 42-year-old patient presented with 10-year history of urinary urgency along with pain, numbness, and itchiness in the right hand and foot, which worsened and started affecting the left side over the past six months. The symptoms occurred predominantly at night, improved with urination and movement, and affected daily activities. Symptoms completely resolved with pramipexole treatment. The diagnostic criteria for RLS acknowledge atypical variants involving various body parts. Reported cases include genital, bladder, abdominal, bowel, head, oral, and phantom limb variants. Clinicians should consider therapeutic testing, such as with low-dose dopamine agonists, when there is a high clinical suspicion.
Accessory inferior pancreatic artery and aberrant left colic artery: a case report
Authors: Gülcan Melisa , Demirçubuk İbrahim , Köseoğlu Melek , Bilge Okan
Published: June 2024

The left colic artery generally emerges from the inferior mesenteric artery and then divides into ascending and descending branches. Arterial supply of the pancreas is provided by the superior mesenteric artery and the celiac trunk. During a routine cadaver dissection in a male body donor, two anatomical variations in the arterial pattern of the pancreas and colon were observed. An anomalous common trunk, originating from the superior mesenteric artery, gave rise to two branches: an accessory inferior pancreatic artery to the head of the pancreas, and the aberrant left colic artery. A comprehensive knowledge of vascular variations of this region is valuable in visceral surgery and interventional radiology. Hence, this case report may provide further anatomical knowledge for vessel management in the pancreas and colon surgical procedures.
Peran Guru dalam Membangun Toleransi dan Menangkal Intolerasi di Kalangan Siswa [The Role of Teachers in Building Tolerance and Countering Intolerance among Students]
Authors: Debora Theresiana , Dwikristanto Yanuard Putro
Published: June 2024

Indonesia is a country with a diverse society. Diversity can bring conflict to society, but tolerance is essential to maintaining it. Education is a key starting point for fostering tolerance. This requires teachers to carry out their role in instilling moral values in society based on the correct philosophical foundation. As the image and likeness of God, despite having fallen into sin and experiencing severe damage, humans still have a will and mind that is the basis for humans to be both tolerant and intolerant. This article aims to explore the philosophical role of Christian teachers as mentors, examining how they foster tolerance and intolerance in the classroom. The method used in writing is a literature review. The conclusion is that Christian teachers can use tolerant and intolerant attitudes correctly in the classroom through motivation, spontaneous advice with love, examples of Christ's love, and classroom habits that teach students to love each other and appreciate the work of others while hating sin.

BAHASA INDONESIA ABSTRACT:

Indonesia adalah negara dengan masyarakat yang beragam. Keberagaman ini sering kali menimbulkan konflik di masyarakat. Namun, toleransi merupakan hal yang penting untuk menjaga keberagaman, yang dapat dimulai dari dunia pendidikan. Hal ini menuntut guru untuk menjalankan perannya dalam menanamkan nilai-nilai moral dalam masyarakat dengan berlandaskan pada landasan filosofis yang benar. Sebagai gambar dan rupa Allah, meskipun telah jatuh ke dalam dosa dan mengalami kerusakan yang parah, manusia masih memiliki kehendak dan pikiran yang menjadi dasar bagi manusia untuk bersikap toleran dan intoleran dengan benar. Artikel ini bertujuan untuk memberikan gambaran mengenai peran guru Kristen sebagai pembimbing dalam menumbuhkan sikap toleransi dan intoleransi di dalam kelas secara filosofis. Metode yang digunakan dalam penulisan adalah tinjauan pustaka. Kesimpulan yang diperoleh adalah guru Kristen dapat menggunakan sikap toleran dan intoleransi dengan benar di dalam kelas melalui motivasi, nasihat spontan dengan kasih, teladan kasih Kristus, dan kebiasaan di dalam kelas yang mengajarkan siswa untuk saling mengasihi dan menghargai karya orang lain serta membenci dosa.
Analiza środków prawnych pozwalających na dokonanie waloryzacji umowy zamówienia publicznego
Authors: Bochenek Maciej
Published: June 2024

W artykule przedstawiono środki prawne, które pozwalają na dokonanie waloryzacji zamówienia publicznego. Autor obejmuje analizą zarówno środki prawne zawarte w ustawie kodeks cywilny, jak i te zawarte w ustawie prawo zamówień publicznych. Artykuł szczegółowo opisuje przesłanki stosowania klauzul waloryzacyjnych, klauzuli rebus sic stantibus i dokonywania zmian w umowie zamówienia publicznego w przypadkach wskazanych w umowie. Część artykułu poświęcona została na przedstawienie i ocenę zmian wprowadzonych Tarczą Prawną w zakresie waloryzacji zamówień publicznych.
A finalidade do homem: ensaio de comentário da q. 6, a. 2 da Suma Teológica de Tomás de Aquino
Authors: Fernandes João Victor , Maciel Josemar de Campos
Published: June 2024

O trabalho que segue objetiva ser um comentário de um artigo da Suma Teológica de Santo Tomás de Aquino (ST, I, q. 6, a. 2), que se enuncia mediante a pergunta: “Tem o sumo bem a ideia de fim último?”. A partir desse artigo, estruturar-se-á uma orientação para a discussão do problema ético e filosófico do fim último do ser humano. Para dar conta da tarefa, o método empregado será o da construção de um ensaio discursivo, baseado no cruzamento de fontes obtidas através da orientação hipertextual que vai acontecendo nas leituras e na identificação de áreas de estudo e comentadores. Na medida do possível, espelha-se também a estrutura dialética da construção argumentativa, típica da literatura sumística medieval.
Docência, currículo e negritude: caminhos (re)existentes de afeto e dissidência na prática alfabetizadora
Authors: Batista Patrícia Barros Soares , Ribeiro Bruna D´Carlo Rodrigues de Oliveira , Cavalcanti Ana Paula Campos
Published: June 2024

O currículo, compreendido como um território e lócus de disputa de poder, configura-se como uma instância colonizada e colonizadora ao evidenciar e legitimar saberes e práticas arraigados em padrões hegemônicos opressores assentados em bases brancocêntricas. Buscando (re)construir uma outra lógica diante desse cenário, a escola, ao optar por caminhos de resistência, configura-se como um espaço de reconhecimento e valorização da diversidade por meio de interpelações pedagógicas, éticas e políticas dissidentes. Este artigo apresenta, por meio de cartas (auto)narrativas, reflexões sobre as práticas curriculares afrocentradas nos anos iniciais do ensino fundamental. A experiência de docentes negras de uma escola federal de educação básica tem evidenciado, por meio das ações vinculadas ao projeto de ensino e pesquisa Áfricas e Eu, a abertura de frestas curriculares para a valorização e emancipação da negritude, rompendo com a lógica da coisificação (Césaire, 2020) dos corpos e dos saberes africanos e afro-brasileiros. Concluímos que evidenciar o protagonismo e a potência negra nas práticas de leitura, escrita e oralidade junto a crianças em processo de alfabetização é um ato de (re)existir diante das estruturas e padrões de poder desumanizadores. Assim, caminhos são abertos para que vozes outras ecoem e constituam narrativas de emancipação das diferentes formas de existir no mundo, tendo como matriz primeira a humanização a partir de um currículo afrocentrado e afetuoso.
Modos de aprontar na academia: escrevivências e fabulações curriculares
Authors: Oliveira Iris Verena
Published: June 2024

O texto trata sobre modos de aprontar a pesquisa em educação, especialmente no campo do currículo, a partir do conceito de escrevivências, da escritora Conceição Evaristo (2020). Seu fio condutor são fabulações curriculares (Hartman, 2022) que articulam práticas pedagógicas na escola e na universidade, a partir da experiência de ensino e orientação em um mestrado profissional em Educação. A condição diferenciada do Programa permite colocar em questão as concepções de lócus, objeto e pesquisado. O diálogo com as intelectuais negras Beatriz Nascimento (2022) e Sueli Carneiro (2023) possibilita a discussão sobre o conceito de epistemicídio, que se dá via desgaste de alguns debates, além da separação entre obra e autoria. Através de demandas curriculares apresentadas por estudantes da educação básica, proponho modos de fazer pesquisa inspirados nas escrevivências docentes.
Eating Habits and Age at Menarche in Junior High School Female Students in DKI Jakarta Province in 2023
Authors: Christanti Stefani , Syafiq Ahmad , Fikawati Sandra
Published: June 2024

Background: The age at menarche tends to be younger in the last few decades, even though earlier or later menarche can impact physical and psychological health. Nutritional factors, including eating habits, are important and modifiable predictors of menarche age. 
Objectives: To analyze eating habits’ effect on the menarche age by considering factors of nutritional status, level of physical activity, psychological state, and socioeconomic conditions.
Methods: A cross-sectional study was conducted on 420 female students from 15 junior high schools in DKI Jakarta Province in May 2023. Eating habits were measured using the Semi-FFQ questionnaire, while the menarche age and other factors were obtained through interviews, questionnaires, and weight and height measurements.
Results: The menarche age ranged from 8.92 years to 14.33 years, with an average of 11.74 years. Respondents tend to consume carbohydrates, fat, protein, sugar, and salt ≥100% RDA. However, 70.7% of respondents have <100% RDA fiber eating habits. Low fiber diet (<29 grams/day) is significantly related to earlier menarche age based on the T-test (p=0.006) or logistic regression test after controlling for eating habits of fat, protein, and salt (p=0.047) with OR=0.569 (95% CI 0.325-0.993). The analysis also found that nutritional status and socioeconomic conditions were related to the menarche age.
Conclusions: Low fiber diet has a 1.76 times chance of menarche earlier than high fiber diet. A balanced nutritional intake, including vegetables and fruit as a source of fiber, is recommended to support adolescent growth and development, puberty, and general health.
 
Keywords: age at menarche, eating habits, fiber, junior high school female students
Peran Ayah terhadap Kejadian Stunting pada Balita di Perdesaan
Authors: Sugianti Elya , Putri Berliana Devianti , Buanasita Annas
Published: June 2024

Latar Belakang: Stunting masih menjadi isu permasalahan global yang belum terselesaikan. Peranan ibu ditemukan menjadi penyebab yang dominan terhadap kejadian stunting. Namun sejauh ini, peranan ayah dalam peningkatan kejadian stunting belum banyak diulas pada penelitian terdahulu.
Tujuan: Penelitian ini bertujuan untuk menganalisis peranan ayah terhadap kejadian stunting pada balita di perdesaan.
Metode: Penelitian menggunakan desain case control. Penelitian dilakukan di Kabupaten Jombang. Sebanyak 158 sampel usia 24-59 bulan dilibatkan pada penelitian ini. Analisis data menggunakan uji chi-square, fisher exact dan regresi logistik
Hasil: Ayah yang berpendidikan rendah berpeluang 2,407 kali lebih tinggi meningkatkan risiko balita menjadi stunting (p=0,010; OR=2,407). Ayah dengan jumlah keluarga lebih dari empat orang berpeluang 1,971 kali lebih tinggi memiliki balita stunting  (p=0,042; OR=1,971) dibandingkan ayah dengan jumlah anggota kurang dari 4 orang.
Kesimpulan: Pelibatan ayah dalam pengasuhan anak penting untuk mencegah balita dari stunting. Edukasi gizi sebaiknya tidak hanya berfokus kepada ibu balita, akan tetapi juga kepada ayah balita. Perbaikan ekonomi keluarga pada rumah tangga dengan jumlah anggota besar penting untuk memperbaiki status gizi balita.
Sensory Test and Poximate Analysis Content Test of Porang Flour (Amorphophallus Muelleri) and Tempe Flour Flakes
Authors: Tarigan Novriani , Tarigan Fifi Nurjannah , Sherlina Sherlina , Hasibuan Yolanda Oktaviani , Saragih Meysalina
Published: June 2024

Background: Porang is local food that contains glucomannan beneficial for accelerating satiety. Therefore, they are good food for diets.
Objectives: To determine the chemical and sensory content of flakes formulated from porang flour and tempe flour.
Methods: This study used a Completely Randomized Design, three treatments and three repetition. The sensory test was conducted on 50 students of Medan Health Polytechnic. Proximate test was conducted to measure the levels of carbohydrate, protein, fat, water, ash, crude fiber, and glucomannan. Data were analyzed with Analysis of Variance (ANOVA). Furthermore, Multiple Range Test (DMRT) was conducted at 5% and calcium oxalate.
Results: The sensory test results showed that the color of flakes in treatments 1, 2, and 3 was different, and treatment 3 was the most preferred. The flavor was also different between treatments, and treatment 1 was the most preferred. However, the aroma and texture of porang flour and tempeh flakes did not change after processing. The highest levels of water, ash, protein, fat, crude fiber and breakability were in treatment 3, while the highest levels of carbohydrate, glucoman and calcium oxalate were in treatment 1. The higher proportion of porang flour resulted in better or higher glucoman levels, but with increased calcium oxalate levels. Further studies need to be carried out, in order to produce low and consumable calcium oxalate levels that fulfill the health requirements.
Conclusions: Porang flour and tempe flour influenced the sensory test and chemical content test.
Associations of Fast-Food Consumption Patterns, Sugar-Sweetened Beverages, and Fibre Intake with Blood Cholesterol in Young Adult
Authors: Sari Hesti Permata , Sulistyaning Afina Rachma , Wicaksari Sifa Aulia , Putri Windi Prisria , Widyaningtyas Elok
Published: June 2024

Background: Hypercholesterolemia, defined as cholesterol levels of 200 mg/dl or above, is often attributable to lifestyle shifts, including changes in dietary habits, particularly noticeable in young adults.
Objectives: This study seeks to establish the relationship between patterns of fast food and sugar-sweetened beverage (SSB) consumption, dietary fiber intake, and blood cholesterol levels in young adults.
Methods: An observational, cross-sectional study was conducted on 100 participants, selected through purposive sampling. The selection criteria included age between 18-25, non-smokers, no prior diagnosis of dyslipidemia or CHD, no family history of dyslipidemia, and not currently on a diet. The Food Frequency Questionnaire (FFQ) was used to gather data on fast food and SSB intake, dietary fiber intake was assessed through food records, and cholesterol levels were measured using the Easy Touch GCU tool. The chi-square likelihood test and Spearman rank were used to analyze the data.
Results: The study revealed that 48% of participants had cholesterol levels of ≥200 mg/dl. Descriptive analysis showed that 46% of participants frequently consumed fast food, 53% frequently consumed SSBs, and all participants had a daily fiber intake of less than 25 g. Bivariate analysis revealed significant correlations between cholesterol levels and patterns of fast-food consumption (p-value=0.000), SSB intake (p-value=0.000), and dietary fiber intake (p-value=0.019), all with a negative directional correlation.
Conclusions: Young adults with cholesterol levels of ≥200 mg/dl were predominantly those who frequently consumed fast food and SSBs, and had a low intake of dietary fiber.
The Income Tax of Breadwinner Wives in Indonesia: Law and Economics Approach
Authors: Johan Arvie
Published: June 2024

The inequality of employment opportunities between women and men in Indonesia is quite worrying: the low employment of women, the low income of women, the minimum number of women who reach the top of their careers, and the majority of women are positioned as housekeepers. Inequality attracts the issue of income tax of breadwinner wives. The income tax regulations already accommodate equality between men and women, but various groups including the Indonesia Minister of Finance consider this regulation to be insufficient. This article analyzes imposition of income tax on women in relation to the discrepancies of breadwinner roles between women and men. This article applies a law and economics approach, focusing on the importance of efficiency in order to maintain gender-neutral equality. The result, is that the approach in the context of income tax is applicable in Indonesia by introducing the concept of imputed income based on provincial minimum wage, and by applying lower tax income rate for breadwinner wives. The introduction of imputed income based on provincial minimum wage requires regulatory support from the national social security system in order to include non-wage workers. This article concludes that the key to solving inequality problem in income tax regulation is the parity in price or value between husbands and wives, either in the role of homemaker or breadwinner. As suggestion, imputed income must be complemented with the imposition of lower rates on the income of working wives, as the roles of husbands as breadwinner and wives as breadwinner are in close substitution. Consequently, the bargaining power of wives for the role of breadwinners is stronger.
Legal Protection for Third Parties in Good Faith on Actio Pauliana Litigation in Bankruptcy Proceedings
Authors: Wiguna I Nyoman , Andaretna Laila Maghfira , Budianto Michael Christian , Vala Tanaya Anindhita
Published: June 2024

Actio Pauliana in bankruptcy, as stipulated under Law Number 37 of 2004, empowers the Curator to seek the annulment of transactions undertaken by the bankrupt debtor, causing harm to the bankrupt estate. Actio Pauliana requires proof that a third party, the debtor's transaction partner is proven to not have acted in good faith, as outlined in the law. However, the legislation lacks clarity on the criteria safeguarding third parties in good faith against Actio Pauliana claims. This research employs a doctrinal research method involving a statute, conceptual, case, and comparative approach. The novelty of this research expounds upon and elucidates the need for amendments to Law Number 37 of 2004, particularly concerning the criteria protecting third parties in good faith. These criteria could be differentiated based on the third parties' position in bankruptcy and the nature of the objects constituting the bankrupt estate, including tangible and intangible movable objects, unregistered objects, immovable objects, and/or registered objects. Furthermore, proposed improvements to the law include refining provisions related to creditors' right to file Actio Pauliana lawsuits, affirming a one-year period rather than a deadline, and addressing timelines within Actio Pauliana lawsuits. Actio Pauliana claims should only be submitted after the debtor's bankruptcy declaration, excluding the Suspension of Debt Payment Obligations (PKPU) process. In conclusion, the research proposes possible solutions, such as the issuance of a Regulation (Perma) or a Circular Letter (SEMA) by the Supreme Court, containing the essential improvements to Law Number 37 of 2004.
Copper Supplementation in Young Wistar Rats
Authors: Kitala–Tańska Klaudia , Hanć Anetta , Juśkiewicz Jerzy , Majewski Michał
Published: June 2024

Supplementation with 200% of the recommended daily dietary quantity of copper modified vascular contraction and relaxation through increased reactive oxygen species (ROS) and prostaglandin formation, which modified the antioxidant status of middle–aged rats. In this study, young (1 month old) male Wistar rats (n/group = 10) received a diet supplemented with 6.45 mg copper/kg (100%—Group A) for 8 weeks. The experimental group received 12.9 mg copper/kg of diet (200%—Group B). Experimental supplementation with 200% copper increased the copper concentration in the blood, liver, and kidneys; increased the ROS concentration in the aortic rings; and enhanced the sensitivity of the aortic rings to acetylcholine. We observed increased participation of nitric oxide (NO) derived from inducible NO synthase (iNOS) in vascular contraction and a decreased net effect of vasodilator prostanoids derived from cyclooxygenase–2 (COX–2) in vascular relaxation. Supplementation with 200% copper was less significant than expected after previous studies conducted with middle–aged rats.
Development of an Adaptive Fuzzy Integral-Derivative Line-of-Sight Guidance Law for Bathymetric LiDAR Onboard USV
Authors: Zhou Guoqing , Wu Jinhuang , Gao Ke , Song Naihui , Jia Guoshuai , Zhou Xiang , Xu Jiasheng , Wang Xia
Published: June 2024

Previous control methods developed by our research team cannot satisfy the high-accuracy requirements of unmanned surface vessel (USV) path-tracking during bathymetric mapping because of the excessive overshoot and slow convergence speed. For this reason, this study developed an adaptive fuzzy integral-derivative line-of-sight (AFIDLOS) guidance law for USV path-tracking control. Integral and derivative terms were added to counteract the effect of the sideslip angle, with which the USV could be quickly guided to converge to the planned path for bathymetric mapping. To obtain a high-accuracy of the look-ahead distance, a fuzzy control method was proposed. The proposed method was verified using simulations and outdoor experiments. The results demonstrate that the AFIDLOS guidance law can reduce the overshoot by 79.85%, shorten the settling time by 55.32% in simulation experiments, and reduce the average cross-track error by 10.91%, and can ensure a 30% overlap of neighboring strips of bathymetric LiDAR outdoor mapping when compared with the traditional method.
Entanglement and Generalized Berry Geometrical Phases in Quantum Gravity
Authors: CIRILO-LOMBARDO Diego J , SANCHEZ Norma G.
Published: June 2024

A new formalism is introduced that makes it possible to elucidate the physical and geometric content of quantum spacetime. It
is based in the Minimum Group Representation Principle (MGRP). Within this framework new results for entanglement and geometrical/topological phases are found and implemented in cosmological and black hole space-times.
Our main results here are:
{\bf(i)} We find the Berry phases for inflation and for the cosmological perturbations and express them in terms of the observables, as the spectral scalar and tensor indices, $n_S$ an $n_T$, and the tensor to scalar ratio $r$. The Berry phase for de Sitter inflation is imaginary with the sign describing the exponential acceleration.
{\bf(ii)} The pure entangled states in the minimum group (metaplectic) $Mp(n)$ representation for quantum de Sitter space-time and black holes are found. {\bf(iii)} For entanglement, the relation between
the Schmidt type representation and the
physical states of the $Mp(n)$ group
is found: This is a {\it new non-diagonal} coherent state
representation complementary to the known
Sudarshan diagonal one. {\bf(iv)} Mean value generators of $Mp(2)$ are
related to the adiabatic invariant and topological charge of the spacetime (matrix element of the
transition $-\infty < t < \infty$). {\bf(v)} The basic {\it even} and {\it odd} $n$-sectors of the Hilbert space are intrinsic to the quantum spacetime and its discrete levels (in particular continuum for $n \rightarrow \infty$), they do not require any extrinsic generation
process as the standard Schrodinger cat
states, and are {\it entangled}. {\bf(vi)} The gravity or cosmological domains in one side and another of the Planck scale are {\it entangled}. Examples: The quantum primordial trans-Planckian de Sitter vacuum and the classical late de Sitter vacuum today; the central quantum gravity reqion and the external classical gravity region of black holes. The classical and quantum dual gravity regions of the space-time are entangled. {\bf(vii)} The general classical-quantum gravity duality is associated to the Metaplectic $Mp(n)$ group symmetry which provides the complete full covering of the phase space and of the quantum space-time mapped from it.
Examination of the Effect of Dimethyl Trisulfide in Acute Stress Mouse Model with the Potential Involvement of the TRPA1 Ion Channel
Authors: Göntér Kitti , Dombi Ágnes , Kormos Viktória , Pintér Erika , Pozsgai Gábor
Published: June 2024

Polysulfides are endogenously produced in mammals and generally associated with protective functions. Our aim was to investigate the effect of dimethyl trisulfide (DMTS) in a mouse model of acute stress. DMTS activates transient receptor potential ankyrin 1 (TRPA1) channels and leads to neuropeptide release, potentially that of substance P (SP). We hypothesize that DMTS might inhibit the degrading enzymes of endocannabinoids, so this system was also investigated as another possible pathway for mediating the effects of DMTS. Trpa1 gene wild type (WT) and knock out (KO) mice were used to confirm the role of the TRPA1 ion channel in mediating the effects of DMTS. C57BL/6J, NK1 gene KO, and Tac1 gene KO mice were used to evaluate the effect of DMTS on the release and expression of SP. Some C57BL/6J animals were treated with AM251, an inhibitor of the cannabinoid CB1 receptor, to elucidate the role of the endocannabinoid system in these processes. Open field test (OFT) and forced swim test (FST) were performed in each mouse strain. Tail suspension test (TST) was performed in TRPA1 WT and KO animals. C-FOS immunohistochemistry was carried out on TRPA1 WT animals. DMTS treatment increased the number of highly active periods and decreased immobility time in the FST in WT animals, but had no effect on Trpa1 KO mice. DMTS administration induced neuronal activation in stress-related brain areas such as the locus coeruleus, dorsal raphe nucleus, lateral septum, paraventricular nucleus of the thalamus, and paraventricular nucleus of the hypothalamus. DMTS may have a potential role in the regulation of stress-related processes, and the TRPA1 ion channel may also be involved in mediating the effects of DMTS. DMTS can be an ideal candidate for further study as a potential remedy in stress-related disorders.
HE INFLUENCE OF THE COVID-19 PANDEMIC ON THE DIVERTICULAR DISEASE COMPLICATIONS TREATMENT
Authors:   Kazan State Medical University, KARPUKHIN OLEG Yu. , PANKRATOVA YULIA S. ,   Kazan State Medical University, SHAKIROV RAIS R. ,   Republican Clinical Hospital, Kazan, CHERKASHINA MALIKA I. ,   Republican Clinical Hospital, Kazan
Published: June 2024

Abstract. Introduction. The COVID-19 pandemic affected not only the organization of the entire healthcare system, but also made adjustments to the diagnosis and treatment of a wide range of diseases, including diverticular disease. Aim. Analysis of the results of inpatient care for patients with acute diverticulitis during the COVID-2019 pandemic. Material and methods: From 2017 to January 2022, 244 patients with diverticular disease were treated in coloproctology clinic. During the pandemic period (March 2020 – December 2021) there were 15 patients with COVID-2019 associated pneumonia who developed complications of diverticular disease. Results and discussion. An increase of hospitalizations of patients with complicated forms of the disease was established, while patients with uncomplicated diverticular disease were hospitalized less frequently. There was also a decrease in the number of reconstructive surgeries in 2020. The most informative diagnostic tool that allows to verify complicated forms of diverticular disease and determines further treatment tactics, especially in the COVID -19 pandemic, is X-ray computed tomography with intravenous contrast, which was performed in 53.3% of patients. The number of urgent surgical interventions increased, including in patients with COVID - 2019. During the pandemic, minimally invasive interventions began to be performed more often, allowing the patient to be treated as gently as possible. Moreover, drainage of abscess under ultrasound guidance is currently becoming a popular procedure even with large abscesses (>3 cm). This technology should be considered as bridge operation before a radical intervention, which implementation should be carried out after the stabilization of the general condition of the patient. Diffuse peritonitis in COVID-positive patients continues to be considered as an indication for emergency laparotomy. At the same time, Hartmann-type operations should be performed, refusing the extended intestinal resection and primary anastomosis. Conclusion. The COVID - 19 pandemic has made adjustments to the organization of medical care for patients with diverticular disease. In this regard, it is advisable to conduct interdisciplinary multicenter research in order to study the influence of the pandemic on the course of the disease and take early measures to minimize the negative consequences of the pandemic
ANALYSIS OF THE DIAGNOSIS AND TREATMENT OF PATIENTS WITH COVID-19 AT A TEMPORARY INFECTION HOSPITAL DEPLOYED IN A MULTIDISCIPLINARY CITY HOSPITAL
Authors:   Kazan State Medical University, VIZEL ALEXANDER A. , KHADEEVA VASILY Z. ,   City Clinical Hospital № 12, Kazan, VIZEL IRINA YU. ,   Kazan State Medical University, AMIROV NAIL B. ,   Kazan State Medical University, SAUBANOVA KARINA O. ,   Kazan State Medical University, VIZEL LEONID A. ,   Kazan (Volga Region) Federal University
Published: June 2024

Abstract. Introduction. The novel coronavirus infection COVID-19, caused by SARS-COV-2, has been a global health problem for three years now. A new challenge is virus mutations that change clinical manifestations and response to therapy. Aim. The aim of the workwas to assess the condition of patients with COVID-19 treated in a temporary infectious diseases hospital deployed in a non-infectious multidisciplinary hospital and to identify factors influencing the outcomes of this disease through a retrospective analysis of clinical observations. Material and methods. An analysis of the condition of 92 patients with COVID-19 (ICD-10 codes U07.1 and U07.2) treated in a temporary infectious diseases hospital deployed on the basis of a multidisciplinary hospital is presented. To collect information, the COVIZ program was designed with subsequent export of depersonalized data to the SPSS-18 statistical package. 64 patients recovered and 28 had a fatal outcome. Results and discussion. The work results showed a change in the routing of patients, with a predominance of only patients with a severe course in the hospital. The more frequent prescription of glucocorticosteroids and anti-cytokine drugs also changed the data processing results due to the small number of «control» groups that did not receive these drugs in the hospital. The use of anti-cytokine therapy (levilimab or olokizumab) was more effective in patients younger than 60 years, but in general, 89.1% of those who recovered received these drugs, and 75% of those who died. The data obtained confirmed the high efficiency of early use of subcutaneous anticoagulants and the low efficiency of antibiotic therapy at the stages before the intensive care unit. The frequency of prescribing antibacterial drugs in the dead was 76.8%, and in those who recovered - 57.8%, while later than 8 days from the onset of the disease they were prescribed in 81.8% and 45.9% of cases, respectively (χ² = 7.357; d.f.=1, p<0.01, TcF=0.006, OR=5.294 CI 1.499-18.695). Conclusion. It was concluded that the clinical picture and the effectiveness of ongoing therapy require constant monitoring and analysis to optimize the updated treatment regimens for COVID-19.
Perspectiva econômica do mercado de inovação em tecnologia assistiva: cenário nacional e projeções mundiais
Authors: Rodrigues Amanda , Texeira Caio Henrique , Moraes Antonio , Santos Vagner
Published: June 2024

Objetivo: A tecnologia assistiva (TA) busca suprir ou reduzir o impacto das deficiências na execução de tarefas da vida cotidiana. Embora muitas pessoas necessitem de TA, em 2021, a OMS estimou que apenas uma em cada dez pessoas tinha acesso a ela. Com a oferta retraída e a demanda em alta, observou-se um movimento mundial crescente de inovações em TA e a abertura de um cenário de oportunidades para esse mercado. O objetivo deste artigo é avaliar o mercado de TA no Brasil e as projeções futuras, no cenário mundial. Métodos: A pesquisa foi realizada em três etapas. Primeiramente, foi realizado um estudo bibliográfico do Livro Branco da Tecnologia Assistiva no Brasil (2017), para reconhecimento dos desafios do mercado brasileiro. Em seguida, foi realizado um estudo sobre o cenário de crédito nacional, com foco em financiamento de TA. Para compreensão do mercado mundial, foi realizada uma pesquisa nos sites de análise de mercado de TA. Resultados: Há escassez de TA no Brasil. Os principais fornecedores são pequenas e médias empresas, e são escassos os incentivos fiscais e de crédito, assim como os investimentos em pesquisa, desenvolvimento e inovação. Em escala mundial, o mercado de TA foi avaliado em US$ 21,95 bilhões de dólares em 2022, devendo atingir o valor de US$ 31,22 bilhões de dólares até o ano de 2030. Conclusão: O mercado mundial de TA está em franca expansão e apresenta grande potencial de abertura para novos mercados. Esse cenário reflete um momento de oportunidades de negócio para as empresas nacionais.
Análise de custo-utilidade da gosserrelina no tratamento de pacientes com leiomioma: uma perspectiva do Sistema Único de Saúde
Authors: Prota Francisco , Pachnicki Jan Pawel , Santana Pamela , Donke Pedro , Okumura Lucas , Massaoka Mariana , Wollinger Thiago Luiz , Ogata Gabriel , Nita Marcelo
Published: June 2024

Objetivos: Gosserrelina é indicada para mulheres com leiomioma, por reduzir o risco associado às complicações clínicas. Este trabalho realizou uma análise de custo-utilidade comparando o uso e o não uso de gosserrelina em pacientes com leiomioma sob a perspectiva do Sistema Único de Saúde. Métodos: Um modelo de árvore de decisão foi estruturado para reproduzir o impacto clínico e econômico do uso de gosserrelina antes da miomectomia, cujo comparador seria o não uso de gosserrelina em pacientes elegíveis. Foram considerados: custos médicos diretos e eventos clínicos como complicações intra-hospitalares e tempo de internação. A razão de custo-utilidade incremental é representada pelo custo incremental da gosserrelina por anos de vida ajustado pela qualidade (QALY). Resultados: Em um cenário em que o acesso à gosserrelina é de 51% das pacientes, o custo incremental foi de R$ 629,08. Pacientes no grupo gosserrelina apresentaram um incremento de 0,0261 no QALY. A razão de custo-utilidade incremental foi de R$ 24.019,26 por QALY, ficando abaixo do limiar adotado pelo Ministério da Saúde. Ao variar o percentual de pacientes que recebem gosserrelina para 80% antes de um procedimento cirúrgico, houve um aumento de QALY para 0,5013, reduzindo custos de complicações e a razão de custo-utilidade incremental para R$ 10.581,07 por QALY. No cenário em que 100% das pacientes utilizam gosserrelina, há um aumento de QALY para 0,8290, reduzindo custos de complicações e a razão de custo-utilidade incremental para R$ 10.288,28 por QALY. Conclusão: O uso de gosserrelina possui custo-utilidade favorável, considerando os parâmetros utilizados nesta modelagem econômica. Quando o acesso à gosserrelina é maior, há um decremento expressivo no custo por QALY.
Network meta-analysis of pembrolizumab as monotherapy and in combination with chemotherapy for first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma
Authors: Mojebi Ali , Ramakrishnan Karthik , Ayers Dieter , Keeping Sam , Borse Rebekah , Chirovsky Diana
Published: June 2024

Pembrolizumab monotherapy or in combination with chemotherapy is approved as first-line treatment in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) based on improved overall survival (OS) versus EXTREME regimen in the KEYNOTE-048 trial. The clinical outcomes of pembrolizumab were compared with other recommended first-line treatments in R/M HNSCC in this study through a Bayesian network meta-analysis. A systematic literature review was conducted in July 2022, from which six trials that matched the KEYNOTE-048 patient eligibility criteria were included in the network. The OS and progression-free survival (PFS) outcomes were compared in the approved pembrolizumab indication (i.e., total population for pembrolizumab in combination with chemotherapy and combined positive score [CPS] ≥ 1 population for pembrolizumab monotherapy). A significant OS improvement was observed for pembrolizumab in combination with chemotherapy and pembrolizumab monotherapy versus EXTREME regimen (hazard ratio, 95% credible interval: 0.72, 0.60-0.86; 0.73, 0.60-0.88), platinum+5- FU (0.58, 0.43-0.76; 0.58, 0.44-0.78), and platinum+paclitaxel (0.53, 0.35-0.79; 0.53, 0.35-0.81), respectively. A non-significant numeric trend in OS improvement was observed versus the TPEx regimen. PFS was comparable with most first-line treatments and was improved versus platinum+5-FU (0.48, 0.36-0.64; 0.59, 0.45-0.79). Additional analyses in higher CPS subgroups also showed consistent results. Overall, our study results showed an improvement in OS outcomes versus alternative first-line treatments, consistent with the findings of the KEYNOTE-048 trial. These data support using pembrolizumab as a suitable firstline treatment option in R/M HNSCC.
Role of the Water–Rock System in the Formation of the Composition of Radon Water of the Tulinskoe Field (Novosibirsk)
Authors: Novikov D.A. , Pyryaev A.N. , Sukhorukov V.P. , Maksimova A.A. , Derkachev A.S. , Sukhorukova A.F. , Dultsev F.F. , Chernykh A.V. , Khvashchevskaya A.A. , Medeshova N.A.
Published: June 2024

––We present the first results of comprehensive isotope-geochemical studies of mineral radon waters of the Tulinskoe field (Novosibirsk), aimed at identifying their stages of interaction with the host rocks. By geochemical coefficients Ca/Na, Ca/Mg, Ca/Si, Mg/Si, Na/Si, Si/Na, rNa/rCl, and SO4/Cl, the studied waters are assigned to fracture–vein waters of granitoids. The indices of carbonate mineral saturation of the radon waters show their oversaturation with aragonite, calcite, and dolomite. The waters are also saturated with diaspore, ferrohydrite, gibbsite, and kaolinite, which leads to the deposition of these minerals as secondary phases. In the thermodynamic diagrams, the points of the activities of the radon water components are localized mainly in the stability fields of clay minerals (kaolinite and Na-, Ca-, and Mg-montmorillonites), layered silicates (talc), and zeolites (laumontite). A few points fall in the stability field of silicates (Mg-chlorite). The studied waters of the Tulinskoe field are neutral fresh, with Si = 6.41–9.02 mg/dm3. According to the results of thermodynamic calculations, the radon waters of the Tulinskoe field are in equilibrium with carbonate minerals and hydromicas. Following the classification by S.L. Shvartsev, they are assigned to the Si-Na geochemical type.