bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-inflammatory and immunomodulatory effects of polysaccharide extracted from Wuguchong (maggot) on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice
Authors: Peng Fangli , Zong Junwei , Zhao Tianqi , Shi Peng , Lu Ming , Qu Xueling , Han Xin , Zhao Lin , Jia Zhuqiang , Wang Shouyu
Published: March 2023

Atopic dermatitis (AD) is an inflammatory, heterogeneous, chronic skin disorder characterized by recurrent eczematous lesions and intense pruritus, and the pathophysiology mechanism of AD is known for immune dysregulation and inflammatory responses. Wuguchong (maggot) has been widely used in the wound field and found with pharmacological properties of the anti-inflammatory and immunomodulatory function. Recently, some polysaccharides were proven to have beneficial effects on AD skin lesions in mice and humans. However, the effect of the polysaccharide extracted from Wuguchong (PEW) on AD remains to be investigated. In the present study, we examined the anti-inflammatory and immunomodulatory effects of PEW on AD and explored the potential mechanisms. Balb/c mice were orally administrated with PEW to evaluate the therapeutic effect of PEW on 2,4-dinitrochlorobenzene (DNCB)-induced AD. Oral PEW administration significantly ameliorated the lesions and symptoms in AD mice, such as the ear thickness and ear swelling degree, epidermal and dermal thickness, and the infiltration of mast cells. In addition, PEW treatment decreased the levels of serum IgE and histamine, the frequencies of Th1 and Th17 cells, as well as the mRNA expression levels of Th1 and Th17 cytokines and nuclear transcript factors (IFN-γ, T-bet, IL-17A, and ROR-rt). Furthermore, the activation of the NF-κB pathway and the phosphorylation of MAPKs (p38, ERK, and JNK) were significantly suppressed by PEW treatment. Taken together, our study suggests that PEW exerts anti-inflammatory and immunomodulatory effects through inhibition of Th1 and Th17 responses and downregulation of NF-κB and MAPK pathways, PEW would be developed as a promising immune therapy for AD.
Metabolic power and energy expenditure in the German Bundesliga
Authors: Venzke Jan , Weber Hendrik , Schlipsing Marc , Salmen Jan , Platen Petra
Published: March 2023

The aims of the study were to analyze metabolic power (MP) and MP derived parameters for different positions in the German Soccer Bundesliga and to evaluate if classification of high-intensity is more suited using the metabolic power approach instead of using traditional speed-based methods. 1,345 video match analysis (25 Hz) datasets from 380 players in 96 matches of the German first Bundesliga were gathered by an automatic player tracking system. Displacement (speed, acceleration, distance) and energetic (MP, energy expenditure) variables were determined. Intensity was classified utilizing conventional thresholds. Metabolic and running profiles were compared among six positional groups and between the halves of the match respectively (one-way ANOVA). Further, time spent, distance covered and energy expended at high speed (>15.5 km h−1) and high acceleration (>2 m s−2) were compared to those at high MP (>20 W kg−1) (one-way ANOVA) for evaluating if metabolic power is more suited to describe intensity in team sports. Main findings are that central-attacking midfielders (CAM) and central midfielders (CM) expended more energy (CAM: 59.8 ± 4.2 kJ kg−1; CM: 59.6 ± 3.6 kJ kg−1) and covered more distance (CAM: 11,494 ± 765 m; CM: 11,445 ± 638 m) than all other positions (p < 0.001). In the whole group of players, less time (t) and less energy were expended (EE) in high speed (t: 302 ± 84 s; EE: 10.1 ± 2.9 kJ kg−1) and at high acceleration zones (t: 147 ± 24 s; EE: 5.5 ± 1.2 kJ kg−1) when compared to high MP zone (t: 617 ± 141 s; EE: 20.0 ± 4.4 kJ kg−1) (p < 0.001). Furthermore, players covered more distance at high MP (2,464 ± 597 m) than at high speed (1,638 ± 458 m) and much less at high acceleration (359 ± 67 m) (p < 0.001). The higher activity profiles of CAM and CM compared to the other positions indicate the need for higher developed physiological performance in players of these positions. High intensity activities should be interpreted differently when using MP and displacement parameters as indicators of high intensity in soccer.
Differentiation of Andean and Mesoamerican accessions in a proposed core collection of grain amaranths
Authors: Blair Matthew W. , Londoño Jorge M. , Buitrago-Bitar María A. , Wu Xingbo , Brenner David M.
Published: March 2023

Grain amaranths are made up of three New World species of pseudo-cereals with C4 photosynthesis from the dicotyledonous family Amaranthaceae and the genus Amaranthus. They originate in two ecoregions of the Americas, namely, the inter-Andean valleys of South America and the volcanic axis and lowlands of Mexico and Central America. These correspond to two centers of domestications for Andean and Mesoamerican crops, with one cultivated species found in the first region and two found in the latter region. To date, no core collection has been made for the grain amaranths in the United States Department of Agriculture (USDA) germplasm system. In this study, our objective was to create a core for the 2,899 gene bank accessions with collection site data by town or farm site of which 1,090 have current geo-referencing of latitude and longitude coordinates. We constituted the core with 260 genotypes of Amaranthus, which we evaluated with 90 single-nucleotide polymorphism markers. Our goal was to distinguish between Andean and Mesoamerican gene pools of amaranths, including the cultivated species and three possible progenitor or wild relative ancestors along with two more species in an outgroup. Population structure, clustering, and discriminant analysis for principal components showed that Andean species Amaranthus caudatus and Amaranthus quitensis shared fewer alleles with Mesoamerican species Amaranthus cruentus and Amaranthus hypochondriacus, compared to each group individually. Amaranthus hybridus was a bridge species that shared alleles with both regions. Molecular markers have the advantage over morphological traits at quickly distinguishing the Andean and Mesoamerican cultivars and have the added benefit of being useful for following inter-species crosses and introgression.
Global education movement: English as a second language teachers’ perceptions of integrating volatility, uncertainty, complexity, and ambiguity elements in lessons
Authors: Yaccob Nur Syafiqah , Yunus Melor Md , John Dexter Sigan
Published: March 2023

Education evolves and progresses globally in a technology-driven world, highlighting the integration of VUCA elements of volatility, uncertainty, complexity, and ambiguity in lessons. Learners are molded to equip themselves with the world and real-life knowledge in their readiness to adapt to the VUCA world. Global education consists of preparing learners for the VUCA world. This study aimed to investigate the current English as a Second Language (ESL) teaching practices and the ESL teachers’ incorporation of VUCA elements in ESL lessons. This study was conducted quantitatively using a survey questionnaire. This study was administered to 30 ESL teachers from different secondary schools in a district in Malacca. The results from the questionnaire revealed that the ESL participants had positive perceptions toward the adaptation of VUCA in the current ESL lessons. Most of the ESL teachers agreed that they adapted VUCA elements into the activities during lessons, although some showed uncertainty about their knowledge and understanding of VUCA. From the high agreement levels in the findings, it can be concluded that the ESL teachers agreed that VUCA elements through problem-based, digital-based, collaborative, and challenging activities in English lessons are beneficial to assist students’ meaningful and autonomous learning. Based on these findings, implications were made for enhancing ESL teachers’ knowledge, understanding, and skills in adapting VUCA in lessons in response to global education demand.
Barriers and facilitators for smoking cessation in chronic smokers with atherosclerotic cardiovascular disease enrolled in a randomized intervention trial: A qualitative study
Authors: Getz Vilde , Munkhaugen John , Lie Hanne C. , Dammen Toril
Published: March 2023

Objectives

Smoking is common in patients with cardiovascular disease. Despite strong recommendations for cessation and the existence of efficacious pharmacological and behavioral interventions, cessation rates remain low. Therefore, in this study, we explore perceived facilitators and barriers to smoking cessation in patients with atherosclerotic cardiovascular disease who have participated in a cessation intervention study.

Methods

Participants (N = 10) from the intervention arm of a randomized controlled study with access to free cessation support and pharmacological aids completed a semi-structured, in-depth telephone interview after a 6-monthfollow-up between October 2021 and July 2022. The interviews were audio recorded, transcribed, and analyzed according to principles of thematic analysis.

Results

The mean age was 65.7 (range: 55–79) years, and three of the 10 participants were women. Among the participants, five had quit smoking, three had relapsed, and two were persistent smokers. The themes identified encompassed barriers and facilitators to cessation, both including individual and contextual factors. Barriers included the upsides of smoking, difficult life situations, addiction to smoking, smoking in social circles, perceived lack of support and understanding from health professionals. Facilitators included intrinsic motivation, concerns about the health condition, financial implications, specific behavioral strategies, positive influence from the social environment, and helpful components of the cessation intervention.

Conclusion

Smokers with cardiovascular disease who have attended a cessation intervention study report several facilitators weighted against barriers, interacting with the intention to cease smoking. The most important potentially modifiable factors of significance for cessation identified may be addressed through motivational interviews and focus groups with other smokers.
The effectiveness of gluten-free dietary interventions: A systematic review
Authors: Poslt Königová Michaela , Sebalo Vňuková Martina , Řehořková Petra , Anders Martin , Ptáček Radek
Published: March 2023

Celiac disease is a chronic autoimmune gastroenterological disorder in which the digestion of gluten leads to damage and constant inflammation in the small intestine. Moreover, there are associated physical and mental health problems related to celiac disease, i.e., a lower health-related quality of life and increased depression and anxiety symptoms. The only effective treatment for celiac disease is lifelong adherence to a gluten-free diet. However, researchers suggest that strict adherence to a gluten-free diet ranges from 42 to 80%, depending on the definition and method of assessment that was utilized. This review examines interventions designed for those who need to adhere to life-long dietary measures and their success in terms of increasing gluten-free dietary adherence and improving their health-related quality of life. In April 2022, the Scopus, Web of Science, PubMed and ProQuest databases were searched using the following terms: “coeliac disease” OR “celiac disease” AND “gluten free diet” AND “intervention” AND “health related quality of life” AND “diabetes.” Eight studies were suitable for this review. The studies were used to analyze different intervention techniques and their impact on gluten-free dietary adherence, quality of life, and the reasons for dietary nonadherence. The studies revealed statistically significant improvements in the knowledge base regarding celiac disease and the gluten-free diet, dietary adherence and quality-of-life satisfaction immediately after the intervention and at a three-month follow-up. Some studies were also focused on behavioral and cognitive aspects of nonadherence to dietary measures.
From digital museuming to on-site visiting: The mediation of cultural identity and perceived value
Authors: Deng Yuanbing , Zhang Xinhui , Zhang Bowen , Zhang Bei , Qin Jing
Published: March 2023

Introduction

Museums use digital resources to provide online services to the public, and a “digital museuming” boom has started. The mechanism of online museum visiting and its impact on willingness to visit on site has become an important issue of widespread concern. Therefore, based on the theory of presence and cognitive-emotional-behavioral theory, this paper introduces perceived value and cultural identity as mediating variables to explore the influence of the digital museuming experience on the willingness to visit on site from the audience’s perspective.

Method

Questionnaires were distributed, using the snowball sampling method, and 429 valid questionnaires were returned.

Results

The empirical test presents the following results: (1) virtual reality technology multi-dimensionally expands the digital museuming experience; (2) immersion, interaction and available experience promote willingness to visit on-site; (3) hedonic experience in the process of digital museuming cannot be ignored; and (4) perceived value and cultural identity play a mediating role.

Discussion

User experience of visiting virtual museums, perceived value and cultural identity influence user willingness to visit museums in the field, but perceived value does not enhance the user’s cultural identity, maybe due to the inability of the online experience to increase the depth of the experience.
The nature and persistence of the effects of posthypnotic suggestions on food preferences: The final report of an online study
Authors: Zahedi Anoushiravan , Öznur Akalin Renin , Lawrence Johanna E. , Baumann Annika , Sommer Werner
Published: March 2023

The persistence of food preferences, which are crucial for diet-related decisions, is a significant obstacle to changing unhealthy eating behavior. To overcome this obstacle, the current study investigates whether posthypnotic suggestions (PHSs) can enhance food-related decisions by measuring food choices and subjective ratings. After assessing hypnotic susceptibility in Session 1, at the beginning of Session 2, a PHS was delivered aiming to increase the desirability of healthy food items (e.g., vegetables and fruit). After the termination of hypnosis, a set of two tasks was administrated twice, once when the PHS was activated and once deactivated in counterbalanced order. The task set consisted of rating 170 pictures of food items, followed by an online supermarket where participants were instructed to select enough food from the same item pool for a fictitious week of quarantine. After 1 week, Session 3 mimicked Session 2 without renewed hypnosis induction to assess the persistence of the PHS effects. The Bayesian hierarchical modeling results indicate that the PHS increased preferences and choices of healthy food items without altering the influence of preferences in choices. In contrast, for unhealthy food items, not only both preferences and choices were decreased due to the PHS, but also their relationship was modified. That is, although choices became negatively biased against unhealthy items, preferences played a more dominant role in unhealthy choices when the PHS was activated. Importantly, all effects persisted over 1 week, qualitatively and quantitatively. Our results indicate that although the PHS affected healthy choices through resolve, i.e., preferred more and chosen more, unhealthy items were probably chosen less impulsively through effortful suppression. Together, besides the translational importance of the current results for helping the obesity epidemic in modern societies, our results contribute theoretically to the understanding of hypnosis and food choices.
Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance
Authors: Zheng Nanxi , Ou Yangpan , Li Huabing , Liu Feng , Xie Guojun , Li Ping , Lang Bing , Guo Wenbin
Published: March 2023

Objective

Sleep disturbances (SD) are commonly found in patients with major depressive disorder (MDD). This study aims to explore the influence of SD symptoms on clinical characteristics in patients with MDD and to investigate the shared and distinct fractional amplitude of low-frequency fluctuation (fALFF) patterns in these patients with or without SD symptoms.

Methods

Twenty-four MDD patients with SD symptoms (Pa_s), 33 MDD patients without SD symptoms (Pa_ns) and 32 healthy controls (HCs) were included in this study. The fALFF and correlation analyses were applied to analyze the features of imaging and clinical data.

Results

Pa_s showed more severe anxiety and depression than Pa_ns. Compared with Pa_ns, Pa_s exhibited increased fALFF value in the left precuneus. Patients shared abnormal fALFF in the frontal-occipital brain regions. There was a positive correlation between fALFF values of the left precuneus and sleep disturbance scores (r = 0.607, p = 0.0000056734) in all patients in addition to a negative correlation between fALFF values of the left MOG/cuneus and HAMD-17 total scores (r = −0.595, p = 0.002141) in Pa_s. The receiver operating characteristic (ROC) results of the fALFF could be used to discriminate Pa_s from Pa_ns with a specificity of 72.73% and a sensitivity of 70.83%.

Conclusion

Pa_s displayed more serious anxiety and depression symptoms. Patients shared abnormal fALFF in the frontal-occipital brain regions, which may be a common characteristic for MDD. And increased fALFF value in the left precuneus might be a specific neuroimaging feature of MDD patients with SD symptoms.
Adverse childhood experiences affect the health of middle-aged and older people in China: The multiple mediating roles of sleep duration and life satisfaction
Authors: Yin Haojie , Qiu Xueying , Zhu Yan , Yang Qing
Published: March 2023

Background

Although a significant amount of literature has examined the association between childhood adversity and adverse health outcomes, which may be affected by sleep duration and life satisfaction. However, this relationship has not been researched in the Chinese population. This study aimed to assess the association between childhood adversity and health outcomes, with sleep duration and life satisfaction as mediators.

Methods

A total of 14,693 subjects aged 45 and over from the 2018 China Health and Retirement Longitudinal Study (CHARLS) were included. Taking childhood adversity as the independent variable, the health level of middle-aged and older individuals as the dependent variable, and sleep time and satisfaction as the mediating factors, Mplus 8.0 software was used to establish a structural equation model (SEM) to analyze the link between childhood adversity and health level and to explore the mediating effect of target mediators between childhood adversity and health level.

Results

In this study, childhood adversity was positively associated with depression symptoms, activities of daily living (ADL), and the number of chronic diseases (r = 0.116, 0.026 and 0.050, respectively, P < 0.001). Associations between adverse childhood experiences (ACEs) and depressive symptoms, ADL, and number of chronic diseases were mediated by sleep duration and life satisfaction, respectively.

Conclusion

Adversity experienced in childhood can affect the health status of middle-aged and older people. By ensuring adequate sleep and improving life satisfaction, health outcomes can be improved, and the negative effects of childhood adversity can be reduced.
Volumetric assessment of individual thalamic nuclei in patients with drug-naïve, first-episode major depressive disorder
Authors: Chibaatar Enkhmurun , Watanabe Keita , Okamoto Naomichi , Orkhonselenge Nasanbadrakh , Natsuyama Tomoya , Hayakawa Gaku , Ikenouchi Atsuko , Kakeda Shingo , Yoshimura Reiji
Published: March 2023

Introduction

Despite the previous inconsistent findings of structural and functional abnormalities of the thalamus in patients with major depressive disorder (MDD), the disruption of the thalamic nuclei in the pathophysiology of this disorder has not yet been adequately studied. Therefore, we investigated the volumetric changes of thalamic subregions and their nuclei in drug-naïve, first-episode MDD patients. We also investigated the association between HAM-D scores, a clinical scale frequently used to evaluate the severity of depression and thalamic nuclei volumes in MDD patients.

Methods

This study included 76 drug-naïve MDD patients and an equal number of healthy subjects. Magnetic resonance imaging (MRI) data were obtained using a 3T MR system and thalamic nuclei volumes were evaluated using FreeSurfer ver.7.11. The volumetric differences were compared by one-way analysis of covariance (ANCOVA) and to ensure that effects were not accounted for by other factors, age, sex, and ETICV variables were included as covariates.

Results

We observed significant volume reductions of the left whole thalamus (p < 0.003) and several thalamic nuclei mostly on the left side in the MDD group compared with healthy controls (HCs). Furthermore, we have revealed weak negative correlations between several thalamic nuclei volumes and HAM-D total and subscale scores.

Discussion

This is the first research study to investigate alterations of the various thalamic nuclei volumes in MDD patients compared with HCs. Moreover, we first analyzed the association between individual thalamic nuclei volumes and HAM-D subscale scores. Though our study may be restricted at certain levels, especially by the demographic difference between the two groups, they possibly contribute at a preliminary level to understanding the thalamic structural changes at its subregions in patients with drug-naïve, first-episode MDD.
Fungal infections in pediatric patients with acute myeloid leukemia in a tertiary hospital
Authors: Ávila Montiel Diana , Saucedo Campos Alberto , Avilés Robles Martha , Murillo Maldonado Marco Antonio , Jiménez Juárez Rodolfo , Silva Dirzo Marisol , Dorantes Acosta Elisa
Published: March 2023

Introduction

Acute leukemia accounts for more than 30% of all pediatric cancer cases, and of these, 15–20% are acute myeloid leukemia (AML). Children who super from AML are more likely to develop infections due to the humoral and cellular immune deficits generated by the disease and its treatment. The incidence of fungal infections is underestimated; reports show that up to 75% of fungal infections go undiagnosed until autopsy. In only 30 years, the incidence of invasive candidiasis has increased by 40-fold. Thus, the high morbidity and mortality associated with fungal infections in hematological patients make it necessary to adopt preventive measures.

Methods

This work aimed to retrospectively identify pediatric patients with acute myeloid leukemia and invasive fungal diseases (IFDs) in a Latin American tertiary care hospital. A retrospective analysis of 36 clinical records of pediatric patients diagnosed with AML from 2007 to 2017 was carried out.

Results

One hundred and twenty-nine hospitalizations were associated with infectious events. Thirteen patients in our study presented 15 infectious events associated with IFDs (11.6%). Two patients died because of complications related to IFDs (15.3%). The most frequent IFD type was aspergillosis, which was observed in 7 cases, followed by Candidemia, which was observed in 4 cases. The most frequent clinical manifestations were fever and respiratory distress.

Discussion

Mortality due to IFD can be prevented with effective pharmacotherapy. An appropriate antifungal prophylaxis strategy still needs to be developed through larger prospective studies in Latin America.
Workplace aggression against healthcare workers in a Spanish healthcare institution between 2019 and 2021: The impact of the COVID-19 pandemic
Authors: Díaz Aitor , Utzet Mireia , Mirabent Joan , Diaz Pilar , Ramada Jose Maria , Serra Consol , Benavides Fernando G.
Published: March 2023

Objectives

Describe the incidence of first aggressions among healthcare workers (HCWs) before and during the COVID-19 pandemic in a Spanish healthcare institution, according to workers' socio-occupational characteristics and analyze the impact of the pandemic on it.

Methods

A cohort involving HCWs who worked in the institution for at least 1 week each year from 1 January 2019 to 31 December 2021. Adjusted relative risks (aRR) were estimated using generalized estimating equations and negative binomial models to calculate the differences in WPA between the different time periods. All analyses were stratified by gender.

Results

Among women, the incidence was 6.8% (6.0; 7.8) during the pre-COVID-19 period, 6.0% (5.2; 7.0) during the COVID-19 baseline and 5.1% (4.3; 5.9) during the COVID-19 endline; and 4.6% (3.4; 6.1), 5.3% (4.1; 6.8) and 4.4% (3.5; 5.8), respectively, among men. Among men, the incidence of WPA was 4.6 (3.4; 6.1), 5.3 (4.1; 6.8), and 4.4% (3.5; 5.8), respectively. These incidences were significantly higher among male nurses and aides [11.1 (8.0; 15.4), 12.3 (8.9; 16.6), and 9.3% (6.5; 13.3) during each period] and psychiatric center workers [women: 14.7 (11.2; 19.0), 15.4 (11.8; 19.8), and 12.4% (9.2; 16.6); men: 12.3 (7.2; 20.0), 17.8 (11.6; 26.2), and 14.3% (8.8; 22.4)]. Among women, the risk of WPA was 23% lower in the post-COVID-19 period compared to before the pandemic [aRR = 0.77 (0.64; 0.93)], while the risk during the COVID-19 baseline was not significantly different [aRR = 0.89 (0.74; 1.06)].

Conclusions

The COVID-19 pandemic led to an unexpected decrease in first-time WPA against HCWs. However, ~5% of HCWs experienced at least one incidence of aggression in the last follow-up year. Healthcare managers should continue to increase the prevention of aggression against HCWs, especially among vulnerable groups with a higher level of incidence.
The alternate-form reliability study of six variants of the Brief Visual-Spatial Memory Test-Revised and the Hopkins Verbal Learning Test-Revised
Authors: Cai Yumei , Yang Tianlong , Yu Xin , Han Xue , Chen Gong , Shi Chuan
Published: March 2023

Introduction

The revised Hopkins Verbal Learning Test-Revised (HVLT-R) and the Brief Visual-Spatial Memory Test-Revised (BVMT-R) are two widely used test involving verbal and visual learning and memory. In the two tests, six different versions are assembled, respectively, to prevent learning effects. Currently, no researchers have compared the six versions of the two tests. Thus, their usefulness in clinical studies requiring multiple follow-ups is limited. In this work, we confirm the equivalence of six HVLT-R and BVMT-R versions.

Methods

20 people completed all six HVLT-R and BVMT-R versions, while 120 people were randomly assigned to complete one of the six versions of each test. The Intelligence Quotient (IQ) level is measured using the short version of the Wechsler Adult Intelligence test. R4.2.0 is used for statistical analysis. The K-Related sample test (a non-parametric test) is used to observe the differences in test scores among the 20 subjects. The one-way Analysis of Variance (ANOVA) test is utilized to analyze the differences in test scores among the 120 subjects. The scores on different versions are compared using two similar sample tests. The HVLT-R Total Learning, the HVLT-R Delayed Recall, the BVMT-R Total Learning, and the BVMT-R Delayed Recall are indexes for comparison. Version and test scores are used as research factors, while different versions are used as research levels.

Results

The results suggest that HVLT-R and BVMT-R versions 3, 5 and 6 are equally difficult, and relatively easy compared to versions 1, 2 and 4. HVLT-R versions 3, 5, and 6 show good reliability and can be used interchangeably when testing word learning ability or short-term memory; BVMT-R Versions 3, 5, and 6 show acceptable reliability and can be can be used interchangeably.

Discussion

In the study of multiple follow-ups, it is a must to avoid discrepant versions and choose other equivalent versions. The results from this study could be used as a guide for upcoming studies and clinical applications in China.
Assessing the impact of urban greenspace on physical health: An empirical study from Southwest China
Authors: Seyler Barnabas C. , Luo Han , Wang Xiuli , Zuoqiu Sophia , Xie Yao , Wang Yuan
Published: March 2023

Introduction

As the world becomes increasingly urbanized and human-nature contact declines, urban greenspace's impact on human health has garnered growing interest across academic disciplines. Various definitions and multiple indicators of greenspace have been utilized, with most studies finding an overall positive association between greenspace and health. Nevertheless, studies directly comparing how different greenspace indicators impact different disease types have been limited. Moreover, to verify the robustness of conclusions drawn, studies should compare multiple measures of greenspace across various spatial scales. Thus, a more comprehensive analysis is necessary to help inform future study design, especially in determining which greenspace indicators would be most useful in data-limited areas.

Methods

Chengdu, the capital city of Sichuan Province, is West China's largest and most urban city, being typical of other large cities in lower to middle-income countries (LMICs). With twenty county-level jurisdictions spanning various degrees of urbanization, Chengdu's landscape heterogeneity and large population make it ideal for studying greenspace's impact on public health. This study took Chengdu as a case study to assess the association and potential impact of three traditional measures of greenspace (Normalized Difference Vegetation Index, Enhanced Vegetation Index, and Fractional Vegetation Cover) and urban ratio (% of population being urban) on hospitalization rates and medical expenses paid for three major disease categories (circulatory system diseases, neoplasms, and respiratory system diseases).

Results and discussion

We found greenspace did have a significant impact on public health, but this relationship differed by disease type. Greenspace exhibited significant positive association with respiratory diseases, but insignificant negative associations with the other disease categories. Urban ratio showed significant negative association with greenspace abundance. The higher the urban ratio (e.g., less greenspace), the more money was paid on medical expenses. This relationship was found not only in terms of urban ratio being positively correlated with medical expenses, but also in that all three greenspace indicators were negatively correlated with medical expenses. Consequently, in future health outcome studies, urban ratio could be an acceptable negative indicator of greenness in LMICs where urban ratio is likely to imply less greenness.
Deep treasury management for banks
Authors: Englisch Holger , Krabichler Thomas , Müller Konrad J. , Schwarz Marc
Published: March 2023

Retail banks use Asset Liability Management (ALM) to hedge interest rate risk associated with differences in maturity and predictability of their loan and deposit portfolios. The opposing goals of profiting from maturity transformation and hedging interest rate risk while adhering to numerous regulatory constraints make ALM a challenging problem. We formulate ALM as a high-dimensional stochastic control problem in which monthly investment and financing decisions drive the evolution of the bank's balance sheet. To find strategies that maximize long-term utility in the presence of constraints and stochastic interest rates, we train neural networks that parametrize the decision process. Our experiments provide practical insights and demonstrate that the approach of Deep ALM deduces dynamic strategies that outperform static benchmarks.
Hand rehabilitation based on the RobHand exoskeleton in stroke patients: A case series study
Authors: Barria Patricio , Riquelme Matías , Reppich Hannah , Cisnal Ana , Fraile Juan-Carlos , Pérez-Turiel Javier , Sierra David , Aguilar Rolando , Andrade Asterio , Nuñez-Espinosa Cristian
Published: March 2023

Introduction: The RobHand (Robot for Hand Rehabilitation) is a robotic neuromotor rehabilitation exoskeleton that assists in performing flexion and extension movements of the fingers. The present case study assesses changes in manual function and hand muscle strength of four selected stroke patients after completion of an established training program. In addition, safety and user satisfaction are also evaluated.

Methods: The training program consisted of 16 sessions; two 60-minute training sessions per week for eight consecutive weeks. During each session, patients moved through six consecutive rehabilitation stages using the RobHand. Manual function assessments were applied before and after the training program and safety tests were carried out after each session. A user evaluation questionnaire was filled out after each patient completed the program.

Results: The safety test showed the absence of significant adverse events, such as skin lesions or fatigue. An average score of 4 out of 5 was obtained on the Quebec User Evaluation of Satisfaction with Assistive Technology 2.0 Scale. Users were very satisfied with the weight, comfort, and quality of professional services. A Kruskal-Wallis test revealed that there were not statistically significant changes in the manual function tests between the beginning and the end of the training program.

Discussion: It can be concluded that the RobHand is a safe rehabilitation technology and users were satisfied with the system. No statistically significant differences in manual function were found. This could be due to the high influence of the stroke stage on motor recovery since the study was performed with chronic patients. Hence, future studies should evaluate the rehabilitation effectiveness of the repetitive use of the RobHand exoskeleton on subacute patients.

Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT05598892?id=NCT05598892&draw=2&rank=1, identifier NCT05598892.
SHIELD DRIVE Science Center: Efforts in diversification and inclusion in heliophysics
Authors: Buxner Sanlyn , Gross Nicholas , Opher Merav , Wong Joyce , Richardson John
Published: March 2023

We present the broader impacts effort of the NASA SHIELD DRIVE Science Center, summarizing both phase I and now phase II efforts. The purpose of the broadening impact efforts are to address the overall lack of diversity in the space physics workforce through intentional programming intended to increase inclusiveness and explicit support for emerging and early career researchers. Specific efforts include an online repository of testimonials of diverse early career researchers, SHIELD webinars highlighting the human side of eminent scientists, support for REU students at different institutions, and a yearly heliophysics summer school. We also discuss efforts to support heliophysics scientists through community building events and ongoing training. The SHIELD Drive Science Center’s overall broadening impact goal is to train and mentor the next-generation of team-based heliophysicists while accelerating knowledge integration, transfer, and communication across traditional boundaries.
Determining vulnerable households and food groups sensitive to price and income increase from the perspective of food security: Evidence from Iran
Authors: Banaie Elahe , Mojaverian Seyed Mojtaba , Mirzaei Abbas
Published: March 2023

Concerns about household food security of developing countries has been greatly intensified with rising food prices derives from various causes, such as market failure, climate change, political instability, the presence of poor financial institutions, and emerging challenges. It is very important, the development and evaluation of required policy responses such as income compensation policy to cope with foodstuff price increases. It is necessary to pay attention to different household groups regarding income, occupation, and urban/rural conditions in order to evaluate the effects of shocks and policies according to the different responses of households. This paper employes a multimarket equilibrium simulation model and evaluates the effect of price hikes with/without households' nominal income compensation policy on the calorie intake of different household groups. To this end, Iranian households that have suffered from severe food inflation and their nominal income compensation policy has always been the focus of government officials were investigated. First, we noticed that poor rural households with government occupations bear the brunt of ensuing the price hike of foodstuffs. Second, we found that households food security is highly reliant on the price of livestock products compared to other foodstuffs. Finally, we concluded that income compensation policy plays the role of a threat to food security for some households and a driver for others. Therefore, based on the different responses of households to foodstuff price and income increase, we recommended the design of more precise interventions in the market of foodstuff in a more targeted and efficient manner.
Ornithological and molecular evidence of a reproducing Hyalomma rufipes population under continental climate in Europe
Authors: Keve Gergő , Csörgő Tibor , Benke Anikó , Huber Attila , Mórocz Attila , Németh Ákos , Kalocsa Béla , Tamás Enikő Anna , Gyurácz József , Kiss Orsolya , Kováts Dávid , Sándor Attila D. , Karcza Zsolt , Hornok Sándor
Published: March 2023

Reports on adult Hyalomma ticks in certain regions of the Carpathian Basin date back to the 19th century. These ticks were thought to emerge from nymphs dropping from birds, then molting to adults. Although the role of migratory birds in carrying ticks of this genus is known from all parts of Europe, in most countries no contemporaneous multiregional surveillance of bird-associated ticks was reported which could allow the recognition of hotspots in this context. From 38 passeriform bird species 956 ixodid ticks were collected at seven locations in Hungary. Tick species were identified as Ixodes ricinus (n = 598), Ixodes frontalis (n = 18), Ixodes lividus (n = 6), Haemaphysalis concinna (n = 321), and D. reticulatus (n = 1). All 12 Hyalomma sp. ticks (11 engorged nymphs and 1 unengorged larva) were identified as H. rufipes based on three mitochondrial markers. This species was only found in the Transdanubian region and along its southeastern border. The Common Blackbird and the European Robin were the two main hosts of I. ricinus and I. frontalis, whereas H. concinna was almost exclusively collected form long-distance migrants. The predominant hosts of H. rufipes were reed-associated bird species, the Sedge Warbler and the Bearded Reedling, both in their nesting period. This study provides ornithological explanation for the regional, century-long presence of adult Hyalomma ticks under continental climate in the Transdanubian Region of the Carpathian Basin. More importantly, the autochthonous occurrence of a H. rufipes population was revealed for the first time in Europe, based on the following observations: (1) the bird species infested with H. rufipes are not known to migrate during their nesting period; (2) one larva was not yet engorged; (3) the larva and the nymphs must have belonged to different local generations; and (4) all H. rufipes found in the relevant location were identical in their haplotypes based on three maternally inherited mitochondrial markers, probably reflecting founder effect. This study also demonstrated regional and temporal differences in tick species carried by birds.
Modifications of the PI3K/Akt/mTOR axis during FeHV-1 infection in permissive cells
Authors: Ferrara Gianmarco , Longobardi Consiglia , Damiano Sara , Ciarcia Roberto , Pagnini Ugo , Montagnaro Serena
Published: March 2023

FeHV-1 is the causative agent of infectious rhinotracheitis in cats. The relationship between viral infection and the PI3K/Akt/mTOR pathway, as well as its function in crucial physiological processes like as autophagy, apoptosis or the IFN induction cascade is known for other varicelloviruses. However, there is no information on whether autophagy is activated during FeHV-1 infection nor on how this infection modifies PI3K/Akt/mTOR pathway. In this work, we aim to elucidate the involvement of this pathway during cytolytic infection by FeHV-1 in permissive cell lines. Using a phenotypic approach, the expression of proteins involved in the PI3K/Akt/mTOR pathway was examined by Western blot analysis. The findings demonstrated the lack of modifications in relation to viral dose (except for phospho-mTOR), whereas there were changes in the expression of several markers in relation to time as well as a mismatch in the time of activation of this axis. These results suggest that FeHV-1 may interact independently with different autophagic signaling pathways. In addition, we found an early phosphorylation of Akt, approximately 3 h after infection, without a concomitant decrease in constitutive Akt. This result suggests a possible role for this axis in viral entry. In a second phase, the use of early autophagy inhibitors was examined for viral yield, cytotoxic effects, viral glycoprotein expression, and autophagy markers and resulted in inefficient inhibition of viral replication (12 h post-infection for LY294002 and 48 h post-infection for 3-methyladenine). The same markers were examined during Akt knockdown, and we observed no differences in viral replication. This result could be explained by the presence of a protein kinase in the FeHV-1 genome (encoded by the Us3 gene) that can phosphorylate various Akt substrates as an Akt surrogate, as has already been demonstrated in genetically related viruses (HSV-1, PRV, etc.). For the same reasons, the use of LY294002 at the beginning of infection did not affect FeHV-1-mediated Akt phosphorylation. Our findings highlight changes in the PI3K/Akt/mTOR pathway during FeHV-1 infection, although further research is needed to understand the importance of these changes and how they affect cellular processes and viral propagation.
How Optimal Transport Can Tackle Gender Biases in Multi-Class Neural Network Classifiers for Job Recommendations
Authors: Jourdan Fanny , Kaninku Titon Tshiongo , Asher Nicholas , Loubes Jean-Michel , Risser Laurent
Published: March 2023

Automatic recommendation systems based on deep neural networks have become extremely popular during the last decade. Some of these systems can, however, be used in applications that are ranked as High Risk by the European Commission in the AI act—for instance, online job candidate recommendations. When used in the European Union, commercial AI systems in such applications will be required to have proper statistical properties with regard to the potential discrimination they could engender. This motivated our contribution. We present a novel optimal transport strategy to mitigate undesirable algorithmic biases in multi-class neural network classification. Our strategy is model agnostic and can be used on any multi-class classification neural network model. To anticipate the certification of recommendation systems using textual data, we used it on the Bios dataset, for which the learning task consists of predicting the occupation of female and male individuals, based on their LinkedIn biography. The results showed that our approach can reduce undesired algorithmic biases in this context to lower levels than a standard strategy.
Optimization of the Storage Spaces and the Storing Route of the Pharmaceutical Logistics Robot
Authors: Zhang Ling , Lu Shiqing , Luo Mulin , Dong Bin
Published: March 2023

Auto drug distribution systems are used popularly to replace pharmacists when drugs are distributed in pharmacies. The Cartesian robot is usually used as the recovery mechanism. Under non-dynamic storage location conditions, generally, the selected planning route of the Cartesian robot is definite, which makes it difficult to optimize. In this paper, storage spaces were distributed for different drugs, and the route of storing was broken down into multiple path optimization problems for limited pick points. The path was chosen by an improved ant colony algorithm. Experiments showed that the algorithm can plan an effective storing route in the simulation and actual operation of the robot. The time spent on the route by improved ant colony algorithm sequence (IACS) was less than the time spent of route by random sequence (RS) and the time spent of route by traditional ant colony algorithm sequence (ACS); compared with RS, the optimized rate of restoring time with iacs can improve by 22.04% in simulation and 7.35% in operation. Compared with ACS, the optimized rate of restoring time with iacs was even more than 4.70% in simulation and 1.57% in operation. To the Cartesian robot, the optimization has certain guiding significance of the application on the 3D for improving quality.
A 10-Year Ecological Monitoring of Soils and Triticum aestivum in the Impact Zone of a Power Station
Authors: Chaplygin Victor , Dudnikova Tamara , Mandzhieva Saglara , Minkina Tatiana , Barakhov Anatoly , Nevidomskaya Dina , Rajput Vishnu , Litvinov Yuri , Burachevskaya Marina , Chernikova Natalia , Nazarenko Olga , Barbashev Andrey , Sushkova Svetlana
Published: March 2023

Based on 10 years of environmental monitoring located around the emission zone of an electricity supplier, the main regularities have been studied for the content of heavy metals (HMs), such as Pb, Cd, Zn, Cu, Ni, Mn, and Cr, and 16 priority polycyclic aromatic hydrocarbons (PAHs) in the soils of agricultural landscapes and their accumulation in Triticum aestivum. It has been shown that one of the most significant factors for the pollutants accumulation in soils and plants was the prevailing wind direction on the territory and atmospheric transfer of the dust particles of the enterprise with adsorbed pollutants. As the content of pollutants in the soil increased, their accumulation in Triticum aestivum increased with each season to a level exceeding maximum permissible concentrations (MPC), especially for Pb, Cd, and benzo[a]pyrene (BaP). The unambiguous influx of pollutants from the soil into the roots and further into the aboveground organs of the plant was typical only for Mn, Cr, and BaP, and the accumulation of other studied pollutants can be explained by their foliar influx. It has been established that Triticum aestivum was a more tolerant plant with respect to heavy metals pollution than PAHs.
Tourism Development in the Framework of Endogenous Rural Development Programmes—Comparison of the Case Studies of the Regions of La Vera and Tajo-Salor (Extremadura, Spain)
Authors: Castellano-Álvarez Francisco Javier , Robina Ramírez Rafael , Nieto Masot Ana
Published: March 2023

The promotion of rural tourism is one of the measures that has aroused most expectations in the application of the endogenous rural development programmes promoted by the European Commission at the beginning of the 1990s. Using the case study methodology, this research aims to compare the implementation of the aforementioned measure in two regions which, according to their characteristics, could be considered as antagonistic examples: one, La Vera, has all the conditions to successfully develop its tourism sector; the other, Tajo-Salor, with an adverse climate, lacking in outstanding tourism resources and far from the main centres of demand, could be considered the opposite. The results of the research show the risks inherent in an excessive specialisation in tourism within development strategies. Paradoxically, in La Vera, the concentration of investment in the tourism sector has resulted in a higher number of failed and transferred projects, as well as the dissatisfaction of most of its tourism promoters with the viability of their businesses. In contrast, in Tajo-Salor, the results are more positive, despite the fact that this region has given less relative importance to the tourism sector.