bluuebunny/crossref_metadata_2025 huggingface dataset:
RYR1-Related Rhabdomyolysis: A Spectrum of Hypermetabolic States Due to Ryanodine Receptor Dysfunction
Authors: Kruijt Nick , den Bersselaar Luuk Van , Snoeck Marc , Kramers Kees , Riazi Sheila , Bongers Coen , Treves Susan , Jungbluth Heinz , Voermans Nicol
Published: August 2021

:

Variants in the ryanodine receptor-1 gene (RYR1) have been associated with a wide range of neuromuscular conditions, including various congenital myopathies and malignant hyperthermia (MH). More recently, a number of RYR1 variants, mostly MH-associated, have been demonstrated to contribute to rhabdomyolysis events not directly related to anesthesia in otherwise healthy individuals. This review focuses on RYR1-related rhabdomyolysis in the context of several clinical presentations (i.e., exertional rhabdomyolysis, exertional heat illnesses and MH), and conditions involving a similar hypermetabolic state, in which RYR1 variants may be present (i.e., neuroleptic malignant syndrome and serotonin syndrome). The variety of triggers that can evoke rhabdomyolysis, on their own or in combination, as well as the number of potentially associated complications, illustrates that this is a condition relevant to several medical disciplines. External triggers include but are not limited to strenuous physical exercise, especially if unaccustomed or performed under challenging environmental conditions (e.g., high ambient temperature or humidity), alcohol/illicit drugs, prescription medication (in particular statins, other anti-lipid agents, antipsychotics and antidepressants) infection, or heat. Amongst all patients presenting with rhabdomyolysis, genetic susceptibility is present in a proportion, with RYR1 being one of the most common genetic causes. Clinical clues for a genetic susceptibility include recurrent rhabdomyolysis, creatine kinase (CK) levels above 50 times the upper limit of normal, hyperCKemia lasting for 8 weeks or longer, drug/medication doses insufficient to explain the rhabdomyolysis event, and positive family history. For the treatment or prevention of RYR1-related rhabdomyolysis, the RYR1 antagonist dantrolene can be administered, both in the acute phase or prophylactically in patients with a history of muscle cramps and/or recurrent rhabdomyolysis events. Aside from dantrolene, several other drugs are being investigated for their potential therapeutic use in RYR1-related disorders. These findings offer further therapeutic perspectives for humans, suggesting an important area for future research.
Perspectives on Fragment-based Drug Discovery: A Strategy Applicable to Diverse Targets
Authors: Li Qingxin , Kang Congbao
Published: August 2021

Fragment-Based Drug Discovery (FBDD) is a strategy to develop potent lead molecules
and is frequently used in drug discovery projects of the pharmaceutical industry. This method starts
from identifying a small-molecule fragment, which usually binds weakly to the target and follows
with a hit-to-lead step in which the fragment is grown into potent molecules that bind tightly to the
target to affect its function. Quite a few drugs and compounds in clinical trials are developed using
this approach, making FBDD a powerful strategy in drug discovery. FBDD can be applied to multiple
targets and the hit rate in screening can be used in target druggability assessment. In this minireview,
we provide a summary of the development of FBDD. In addition to giving a brief summary
of the methods used in fragment screening, we highlight some methods that are critical in fragment
growth. Biophysical methods and careful chemical modification of the fragments are the key elements
in FBDD. We show several strategies that can be utilized in FBDD. We emphasize that
NMR spectroscopy such as 19F-NMR and 1H-15N-HSQC experiment and X-ray crystallography are
important in FBDD due to their roles in fragment screening and understanding the binding modes
of the fragment hits, which provides a strategy for fragment growth.
Synthesis of Chromen-1-phenylpropan-1-one Derivatives and their Antidepressant/ Anticonvulsant Activities
Authors: Zhang Shan-Shan , Liu Wei-Hua , He Zhi-Wen , Tan Qiu-Wan , Guan Li-Ping
Published: August 2021

Background:

Coumarin and chalcone are important secondary plant metabolites that exhibit
a range of biological activities. Accordingly, the synthetic derivatives and analogs of these molecules
have attracted attention as potential pharmacological agents

Objective:

This study aims to study new antidepressants with high biological activity and low side
effects, and to provide a basis for the treatment of epilepsy and depression.

Method:

In this study, a series of chalcone derivatives containing a coumarin moiety (2a–2s) were
designed, synthesized, and evaluated using classic antidepressant and anticonvulsant mouse models.

Results:

Forced swimming test results revealed that all but one of the compounds tested significantly
decreased immobility time at a dose of 10 mg/kg and exhibited some antidepressant activities. Furthermore,
compounds 2a, 2c, 2h, and 2k exhibited relatively high antidepressant effects in a dosedependent
manner from 10 to 30 mg/kg. Maximal electroshock seizure tests showed that compounds
2a, 2b, 2c, 2h, 2l, 2r, and 2s exhibited anticonvulsant activities at a dose of 30 mg/kg.

Conclusion:

Accordingly, compounds 2a, 2c, and 2h showed promise as antidepressant adjunct
therapy agents for treating depression in patients with epilepsy. Chromatographic neurochemical
analysis of the mouse brain tissue revealed that the antidepressant effects of the compounds may be
mediated by an increase in serotonin level.
Value of Magnetic Resonance Cholangiopancreatography in Santorinicele
and Wirsungocele
Authors: Zhao Xinzhu , Wan Xing , Luo Min , Du Mu , Xie Qiuxia , Zou Qian , Mei Yingjie , Liu Yubao
Published: August 2021

Background:

Former studies showed that magnetic resonance cholangiopancreatography
(MRCP) is useful in diagnosing the presence of santorinicele; however, few studies have evaluated
MRCP in diagnosing wirsungocele and the association between pancreatitis and santorinicele
or wirsungocele. The purpose of the study was to explore the performance of MRCP in diagnosing
santorinicele and wirsungocele and investigate the potential association among pancreatitis, pancreas
divisum, and santorinicele or wirsungocele.

Method:

Sixty-five patients (mean age, 55.68 years; range, 11-82 years) with santorinicele or wirsungocele
were included and sorted into two groups: the santorinicele group (n = 48) and the wirsungocele
group (n = 17). All patients underwent MRCP. The images were evaluated for the appearance
and size of santorinicele or wirsungocele. The diagnostic sensitivity of MRCP was assessed.
Additionally, whether two groups are correlated with pancreas divisum or pancreatitis were
investigated.

Result:

The sensitivity of MRCP in detecting santorinicele and wirsungocele showed no difference
(68.8% and 76.5%, respectively). The proportion of patients who developed pancreatitis in
santorinicele and wirsungocele groups were 60.4% and 11.8%, respectively (p < 0.05). Pancreas divisum
accounted for 77.1% and 11.8% of the patients in the santorinicele and wirsungocele groups,
respectively (p < 0.05). Patients with santorinicele and pancreas divisum tended to be older when
they acquired pancreatitis.

Conclusion:

MRCP could be an alternative imaging method to detect cystic dilation of the pancreatic
duct. Pancreatitis is more common in patients with santorinicele than in those with wirsungocele.
Moreover, santorinicele is more closely associated with pancreatitis than with pancreas divisum.
Studies on Sodium Lauryl Sulphate-supported Thorium (IV) Phosphate: A
New Surfactant-supported Cation Exchange Resin, Useful in Water
Purification
Authors: Somya Amita , Singh Mamata
Published: August 2021

Background:

With the increasing population and decreased quality of drinking water,
new materials and methods for the purification of water need to be developed. This study aims to
present a solution from pollution by proposing the synthesis method of sodium lauryl sulphate
(SLS)-supported thorium (IV) phosphate (ThP), its characterisation and disquisition of analytical
applications by executing dual separations of calcium.

Methods:

SLS ThP was synthesised by the sol-gel method. The synthesised exchanger was characterised
by physicochemical methods, such as powdered X-ray diffraction, scanning electron microscopy,
thermo-gravimetric-differential thermal analysis, EDAX and Fourier transform-infrared
study. Also, its competency towards the ion exchange processes and in analytical chemistry was
verified.

Results:

The prominent characteristic of SLS-supported ThP was its high ion exchange capacity for
sodium ions (3.10 meq/g), which is almost 2.5 times more than the exchange capacity of ThP, i.e.,
1.3 meq/g. The material resulted in a fibrous sheet that is thermally and mechanically stable but
poorly crystalline and shows selectivity towards Ca2+ and Hg2+ ions.

Conclusion:

The synthesised cation exchange material is thermally stable, showing drastically high
exchange capacity and selectivity towards Hg2+ and Ca2+ metal ions, which might be because of the
use of an anionic surfactant, SLS, while the synthesis of ThP plays a key role in enhancing the exchange
capacity and adsorption of specific metals. Therefore, based on the results obtained, the
above-said materials have applications in water purification processes and environmental pollution
control where removal of Hg2+ and Ca2+ is essential.
Advances and Challenges in Kidney Organoids
Authors: Sabapathy Vikram , Costlow Gabrielle , Venkatadri Rajkumar , Dogan Murat , Kumar Sanjay , Sharma Rahul
Published: August 2021

:

The advent of organoids has renewed researchers' interest in in vitro cell culture systems.
A wide variety of protocols, primarily utilizing pluripotent stem cells, are under development
to improve organoid generation to mimic organ development. The complexity of organoids generated
is greatly influenced based on the method used. Understanding the process of kidney organoid
formation gives developmental insights into how renal cells form, mature, and interact with the adjacent
cells to form specific spatiotemporal structural patterns. This knowledge can bridge the gaps
in understanding in vivo renal developmental processes. Evaluating genetic and epigenetic signatures
in specialized cell types can help interpret the molecular mechanisms governing cell fate. In
addition, development in single-cell RNA sequencing, 3D bioprinting and microfluidic technologies
has led to better identification and understanding of a variety of cell types during differentiation
and designing of complex structures to mimic the conditions in vivo. While several reviews
have highlighted the application of kidney organoids, there is no comprehensive review of various
methodologies specifically focusing on kidney organoids. This review summarizes the updated differentiation
methodologies, applications, and challenges associated with kidney organoids. Here
we have comprehensively collated all the different variables influencing the organoid generation.
Microwave-assisted C-C, C-O, C-N, C-S Bond Formation and Multicomponent Reactions Using Magnetic Retrievable Nanocatalysts
Authors: Yadav Manavi , Dutta Mahima , Tanwar Pema , Jain Reena , Srivastava Anju , Sharma Rakesh K.
Published: August 2021

Microwave-assisted organic synthesis has been perceived as one of the most powerful
and sustainable tools to accomplish expeditious organic synthesis through a greener way on account
of its specific features, including targeted heating, reaction homogeneity, rapidity, possible
modifications of activation parameters, improved selectivity, yield and purity, along with simpler
work-up. Another rapidly growing field for the development of the green and sustainable protocol
is the application of magnetic nanocatalysts. They not only meet the need for facile recovery from
the reaction media after completion of a reaction but also provide the best attributes of nanotechnology
along with the elimination of auxiliary substances and catalyst loss, thereby making the overall
process clean, fast and cost-effective. Thus, the amalgamation of magnetic nanocatalysts and microwave
irradiation presents an ideal blend for the development of sustainable methods in synthetic
organic chemistry. Amidst various bond forming reactions, carbon-carbon (C-C) and carbon-
heteroatom (C-X, where X= O, N, S) bond formations are essentially used to devise privileged
molecular scaffolds for synthetic organic and medicinal chemistry. This review gives a succinct
overview of the synthesis and application of various modified magnetic nanocomposites as taskspecific
catalysts for microwave assisted C-C and C-X bond formation reactions in recent years.
Da Esquina Ao Escritório: Uma Análise Sobre A Ausência De Mulheres Transexuais No Mercado De Trabalho Formal Em Goiás
Authors: Rodrigues Gonçalves João Vitor , Simancas Trujillo Ricardo Antonio
Published: August 2021

The aim of this study is to analyze the absence of transsexual women in organizations, based on testimonials that seek to combine the existing relationship between transsexuals and the working world in Goiás. The intention was to give visibility to the main difficulties encountered by transsexuals when trying to enter into the market, in order to contribute to the discussion about alternatives that may promote their insertion. The results indicate that the lack of public policies and the unpreparedness of companies are considered the determining factors that reaffirm their exclusion in the labor market. The methodological approach focuses on literature review and document analysis. As a result of COVID-19, the testimonials were built in a virtual way, using active technologies. In summary, it is necessary to propose actions that ensure the participation of transsexuals from the elaboration to the implementation of business strategies and public policies that could help and guarantee the insertion of transsexual women in the market.
Alcance de la S.A.S. en el derecho societario a la luz del principio de la libertad contractual
Authors: Ortiz Cano María Isabel
Published: August 2021

This article analyzes the legal incentives and obstacles included in the Law 1258/2008 which regulates the Simplified Joint Stock Company type in the colombian legal system. Given the fact that there are a lot of subsidiary rules and very few imperative rules in this Law, allowing the shareholders to create their own rules. For this reason the text contrasts the Simplified Joint Stock Company regulation with the rules of other companies typified in the Colombian Commercial Code, regarding the principle of contractual freedom and its historical development in the corporate law. Furthermore, the text measures the overall scope of the Simplified Joint Stock Company type in the colombian legal system within more than a decade of its existence.
Effectiveness of Text Messaging Interventions on Blood Pressure Control Among Patients With Hypertension: Systematic Review of Randomized Controlled Trials
Authors: Tam Hon Lon , Wong Eliza Mi Ling , Cheung Kin , Chung Siu Fung
Published: August 2021

Background

Controlling blood pressure (BP) is an international health concern, and high BP is a major contributor to cardiovascular disease mortality. Evidence has shown that educational interventions directed at patients potentially improve BP control and adherence to medications and lifestyle modifications. In addition, a text messaging intervention has a potential effect on BP control; however, the dosage of a text messaging intervention has not been determined in previous reviews, resulting in difficult application in practice.

Objective

This review aimed to identify the effectiveness of a text messaging intervention on hypertension management with a specific focus on the dosage of text messaging and the type of additional interventions with text messaging.

Methods

A systematic review was conducted and reported on in accordance with PRISMA guideline. Participants were aged 18 years and older and diagnosed with primary hypertension. The included studies used text messaging as a component of the intervention. We searched for randomized controlled trials published until June 30, 2020, from the following health-related electronic databases: Embase, Medline, CINAHL Complete, PsycINFO, and Scopus. Data were extracted for qualitative synthesis and meta-analysis. The Physiotherapy Evidence Database Scale was used to assess the methodological quality of each study, and the quality of the included studies was assessed independently by two authors.

Results

Twelve studies met the inclusion criteria. The overall methodological quality was fair (mean score 5.75). The frequency of text message delivery varied from daily to biweekly. Health education was identified in 4 studies as an additional intervention with text messaging. The overall results showed that the text messaging intervention significantly reduced systolic BP (SBP) but not diastolic BP (DBP). There was no significant difference in BP reduction between studies that lasted 6 months or less and those that lasted more than 7 months. Seven studies that lasted 6 months or less involving 1428 patients with hypertension were pooled for further meta-analysis. Text messages delivered at a lower frequency (once per week or less) had a small effect on SBP reduction (effect size 0.35, P<.01) and DBP reduction (effect size 0.28, P=.01). In addition, the use of a text messaging intervention halved the odds of uncontrolled BP among patients with hypertension in 6 months (odds ratio 0.46, P=.02).

Conclusions

This review found that a text messaging intervention was effective in BP control. One-way text messaging delivered in a weekly manner was suggested to be effective and required fewer resources. Future studies should use different forms of text message and be integrated into other interventions to improve adherence behaviors and BP control among patients with hypertension.
Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review
Authors: Lang Michael , Lemieux Sébastien , Hébert Josée , Sauvageau Guy , Zawati Ma'n H
Published: August 2021

Background

This study aims to identify a novel potential use for web portals in health care and health research: their adoption for the purposes of rapidly sharing health research findings with clinicians, scientists, and patients. In the era of precision medicine and learning health systems, the translation of research findings into targeted therapies depends on the availability of big data and emerging research results. Web portals may work to promote the availability of novel research, working in tandem with traditional scientific publications and conference proceedings.

Objective

This study aims to assess the potential use of web portals, which facilitate the sharing of health research findings among researchers, clinicians, patients, and the public. It also summarizes the potential legal, ethical, and policy implications associated with such tools for public use and in the management of patient care for complex diseases.

Methods

This study broadly adopts the methods for scoping literature reviews outlined by Arskey and O’Malley in 2005. Raised by the integration of web portals into patient care for complex diseases, we systematically searched 3 databases, PubMed, Scopus, and WestLaw Next, for sources describing web portals for sharing health research findings among clinicians, researchers, and patients and their associated legal, ethical, and policy challenges. Of the 719 candidate source citations, 22 were retained for the review.

Results

We found varied and inconsistent treatment of web portals for sharing health research findings among clinicians, researchers, and patients. Although the literature supports the view that portals of this kind are potentially highly promising, they remain novel and are not yet widely adopted. We also found a wide range of discussions on the legal, ethical, and policy issues related to the use of web portals to share research data.

Conclusions

We identified 5 important legal and ethical challenges: privacy and confidentiality, patient health literacy, equity, training, and decision-making. We contend that each of these has meaningful implications for the increased integration of web portals into clinical care.
A Compassion-Focused Ecological Momentary Intervention for Enhancing Resilience in Help-Seeking Youth: Uncontrolled Pilot Study (Preprint)
Authors: Rauschenberg Christian , Boecking Benjamin , Paetzold Isabell , Schruers Koen , Schick Anita , van Amelsvoort Thérèse , Reininghaus Ulrich
Published: August 2021

BACKGROUND

Digital interventions offer new avenues for low-threshold prevention and treatment in young people. Ecological momentary interventions (EMIs) represent a powerful approach that allows for adaptive, real-time, and real-world delivery of intervention components in daily life by real-time processing of ecological momentary assessment (EMA) data. Compassion-focused interventions (CFIs) may be particularly amenable to translation into an EMI to strengthen emotional resilience and modify putative risk mechanisms, such as stress sensitivity, in the daily lives of young help-seeking individuals.

OBJECTIVE

This study aims to investigate the feasibility, safety, and initial therapeutic effects of a novel, accessible, transdiagnostic, ecological momentary CFI for improving emotional resilience to stress (EMIcompass).

METHODS

In this uncontrolled pilot study, help-seeking youth with psychotic, depressive, or anxiety symptoms were offered the EMIcompass intervention in addition to treatment as usual. The EMIcompass intervention consisted of a 3-week EMI (including enhancing, consolidating, and EMA-informed interactive tasks) administered through a mobile health app and three face-to-face sessions with a trained psychologist intended to provide guidance and training on the CFI exercises presented in the app (ie, training session, follow-up booster session, and review session).

RESULTS

In total, 10 individuals (mean age 20.3 years, SD 3.8; range 14-25) were included in the study. Most (8/10, 80%) participants were satisfied and reported a low burden of app usage. No adverse events were observed. In approximately one-third of all EMAs, individuals scored high on stress, negative affect, or threat anticipation during the intervention period, resulting in real-time, interactive delivery of the CFI intervention components in addition to weekly enhancing and daily consolidating tasks. Although the findings should be interpreted with caution because of the small sample size, reduced stress sensitivity, momentary negative affect, and psychotic experiences, along with increased positive affect, were found at postintervention and the 4-week follow-up. Furthermore, reductions in psychotic, anxiety, and depressive symptoms were found (r=0.30-0.65).

CONCLUSIONS

Our findings provide evidence on the feasibility and safety of the EMIcompass intervention for help-seeking youth and lend initial support to beneficial effects on stress sensitivity and mental health outcomes. An exploratory randomized controlled trial is warranted to establish the feasibility and preliminary evidence of its efficacy.

CLINICALTRIAL
Investigating the Use of Digital Health Technology to Monitor COVID-19 and Its Effects: Protocol for an Observational Study (Covid Collab Study) (Preprint)
Authors: Stewart Callum , Ranjan Yatharth , Conde Pauline , Rashid Zulqarnain , Sankesara Heet , Bai Xi , Dobson Richard J B , Folarin Amos A
Published: August 2021

BACKGROUND

The ubiquity of mobile phones and increasing use of wearable fitness trackers offer a wide-ranging window into people’s health and well-being. There are clear advantages in using remote monitoring technologies to gain an insight into health, particularly under the shadow of the COVID-19 pandemic.

OBJECTIVE

Covid Collab is a crowdsourced study that was set up to investigate the feasibility of identifying, monitoring, and understanding the stratification of SARS-CoV-2 infection and recovery through remote monitoring technologies. Additionally, we will assess the impacts of the COVID-19 pandemic and associated social measures on people’s behavior, physical health, and mental well-being.

METHODS

Participants will remotely enroll in the study through the Mass Science app to donate historic and prospective mobile phone data, fitness tracking wearable data, and regular COVID-19–related and mental health–related survey data. The data collection period will cover a continuous period (ie, both before and after any reported infections), so that comparisons to a participant’s own baseline can be made. We plan to carry out analyses in several areas, which will cover symptomatology; risk factors; the machine learning–based classification of illness; and trajectories of recovery, mental well-being, and activity.

RESULTS

As of June 2021, there are over 17,000 participants—largely from the United Kingdom—and enrollment is ongoing.

CONCLUSIONS

This paper introduces a crowdsourced study that will include remotely enrolled participants to record mobile health data throughout the COVID-19 pandemic. The data collected may help researchers investigate a variety of areas, including COVID-19 progression; mental well-being during the pandemic; and the adherence of remote, digitally enrolled participants.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/32587
Public Health Surveillance Systems in the Eastern Mediterranean Region: Bibliometric Analysis of Scientific Literature (Preprint)
Authors: Saad Randa K , Al Nsour Mohannad , Khader Yousef , Al Gunaid Magid
Published: August 2021

BACKGROUND

The Eastern Mediterranean Region (EMR) hosts some of the world’s worst humanitarian and health crises. The implementation of health surveillance in this region has faced multiple constraints. New and novel approaches in surveillance are in a constant state of high and immediate demand. Identifying the existing literature on surveillance helps foster an understanding of scientific development and thus potentially supports future development directions.

OBJECTIVE

This study aims to illustrate the scientific production, quantify the scholarly impact, and highlight the characteristics of publications on public health surveillance in the EMR over the past decade.

METHODS

We performed a Scopus search using keywords related to public health surveillance or its disciplines, cross-referenced with EMR countries, from 2011 to July 2021. Data were exported and analyzed using Microsoft Excel and Visualization of Similarities Viewer. Quality of journals was determined using SCImago Journal Rank and CiteScore.

RESULTS

We retrieved 1987 documents, of which 1927 (96.98%) were articles or reviews. There has been an incremental increase in the number of publications (exponential growth, R2=0.80) over the past decade. Publications were mostly affiliated with Iran (501/1987, 25.21%), the United States (468/1987, 23.55%), Pakistan (243/1987, 12.23%), Egypt (224/1987, 11.27%), and Saudi Arabia (209/1987, 10.52%). However, Iran only had links with 40 other countries (total link strength 164), and the biggest collaborator from the EMR was Egypt, with 67 links (total link strength 402). Within the other EMR countries, only Morocco, Lebanon, and Jordan produced ≥79 publications in the 10-year period. Most publications (1551/1987, 78.06%) were affiliated with EMR universities. Most journals were categorized as medical journals, and the highest number of articles were published in the Eastern Mediterranean Health Journal (SCImago Journal Rank 0.442; CiteScore 1.5). Retrieved documents had an average of 18.4 (SD 125.5) citations per document and an h-index of 66. The top-3 most cited documents were from the Global Burden of Diseases study. We found 70 high-frequency terms, occurring ≥10 times in author keywords, connected in 3 clusters. COVID-19, SARS-CoV-2, and pandemic represented the most recent 2020 cluster.

CONCLUSIONS

This is the first research study to quantify the published literature on public health surveillance and its disciplines in the EMR. Research productivity has steadily increased over the past decade, and Iran has been the leading country publishing relevant research. Recurrent recent surveillance themes included COVID-19 and SARS-CoV-2. This study also sheds light on the gaps in surveillance research in the EMR, including inadequate publications on noncommunicable diseases and injury-related surveillance.

CLINICALTRIAL
Algoritmos y pandemia. Tres claves emergentes para futuros análisis sobre opinión pública
Authors: Avaro Dante Adalberto
Published: August 2021

Este trabajo analiza la creciente importancia que han tenido los ecosistemas de gestión de la atención durante la etapa pandémica. Se afirma que la consolidación de los sistemas de inteligencia artificial descansa en su capacidad de producir efectos reales, es decir, en su capacidad de “agencia”. Finalmente, se argumenta que la demanda por una mayor regulación de dichos sistemas está limitada a la propia identidad de aquello que requiere ser regulado: los códigos y algoritmos. Esto abre nuevos desafíos tanto para la política pública como para las futuras investigaciones en el campo de la opinión pública.
Pandemia de COVID-19 y abstencionismo en las elecciones municipales del estado de Hidalgo
Authors: Lizama Carrasco Guillermo
Published: August 2021

En este artículo se explora la relación entre el abstencionismo electoral y la pandemia de covid-19 en las elecciones municipales del estado de Hidalgo en 2020. Para ello, se plantea como pregunta: ¿el riesgo colectivo producto de la pandemia de covid-19 provocó una menor participación electoral? La interrogante se debe a que las tasas de contagiados y de fallecimientos por el virus SARS-CoV-2 generan riesgo en la sociedad y, por ende, altos costos para los electores. Para responder a esta pregunta, se emplea una metodología cuantitativa a través de medidas de asociación entre variables (prueba t de Student, correlación de Pearson y coeficiente de determinación). Los resultados se analizan desde el enfoque sociológico del comportamiento electoral e indican preliminarmente que no existe una relación estadística significativa entre la pandemia y la participación; tampoco se observan diferencias importantes en las tasas de abstencionismo comparadas con  aquellas de la elección municipal de 2016.
Plastic Pollution by COVID-19 Pandemic: An Urge for Sustainable Approaches to Protect the Environment
Authors: Bansal Megha , Sharma Jai Gopal
Published: August 2021

COVID-19 pandemic has created a prolonged impact globally and destructed the life all over the world. The necessary use of personal protective equipments, masks, gloves and other plastic products has to some extent reduced transmission of virus. However, the impact of plastic waste generated worldwide due to the pandemic has affected the environment globally. The coronavirus disease (COVID-19) has destructed and altered every part of life and environment globally. Potential impacts on the environment are seen due to the transmission of virus as well as a slowdown in economic activities as lockdown prevails. Increased biomedical waste, improper usage and disposal of surgical masks, disinfectants, gloves, and increasing plastics wastes from domestic households continuously endangers environment. Not only it has an impact on environment, but also deteriorates human health in the future. Global environmental sustainability is necessitated to overcome the plastic pollution problem and facilitate strategies to recycle and reuse plastics products. This review highlights the influence of COVID-19 on wastes generated by plastic products along with environmental challenges and repercussions. Also, measures to combat the plastic pollution problem have to be implemented for future protection and safety of the environment.
Servicios ecosistémicos y su valoración económica ¿Una armonización viable?
Authors:   Corporación Universitaria Remington, Flórez-Flórez Claudia Patricia
Published: August 2021

El trabajo que se ofrece a continuación parte del concepto de servicios ecosistémicos y recursos naturales, cuya afectación por actividades antrópicas busca ser valorada de manera directa o indirecta mediante indicadores y registros económicos que conduzcan a una visibilización financiera del impacto ambiental, esto como insumo para la toma de decisiones en la gestión empresarial y el fortalecimiento del sistema integral de gestión. Es un documento que presenta una revisión bibliográfica de diversos estudios que buscan integrar la valoración económica ambiental y la gestión de los recursos naturales. Se aborda la problemática que incluye, no solo el concepto de servicios ecosistémicos en general, sino también el concepto de servicios ecosistémicos urbanos, con el fin de resaltar un sector con clara incidencia en las condiciones de vida humana por la alta concentración poblacional y por los elevados niveles de generación de residuos y emisión de contaminantes. De la mano del concepto de servicios ecosistémicos, se describen las tendencias y planteamientos que a nivel global se han divulgado como instrumentos de medición que permiten aproximarse a una cuantificación de los impactos sobre los recursos naturales que se derivan de los procesos productivos: análisis del ciclo de vida (ACV), contabilidad de costos del flujo de materiales (CCFM), orientaciones para la medición y evaluación en términos económicos, entre otros instrumentos.
Competencias generales del gerente estratégico de las universidades privadas del estado Zulia
Authors:   Corporación Universitaria Remington, Muñoz-Ruiz Jorge Armando , Amarís López Néstor Enrique
Published: August 2021

En esta investigación se analizan las competencias generales del gerente estratégico de las universidades privadas del estado Zulia, trabajo que se fundamentó en los postulados teóricos de Marafuschi (2014), Hill y Col (2011), Braidot (2010), Blanchard (2010), Alles (2009), Garrido (2009), Robbins (2009) y Mintzberg (1999). En este estudio, tipificado como descriptivo, no experimental, transeccional y de campo, los datos se recolectaron a través de un cuestionario con escalamiento de frecuencias, sometido al juicio de expertos y cuya fórmula alfa de Cronbach fue de 0,92, lo que la ubica en una categoría de muy elevada confiabilidad. El análisis de los resultados demostró la presencia, con un alto nivel, de algunas competencias generales en el líder estratégico de las universidades privadas objeto de estudio, específicamente, las relacionadas con la dirección estratégica, el liderazgo, la toma de decisiones, la gestión de recursos tecnológicos y el manejo de conflictos, fueron aquellas habilidades con mayor frecuencia observables en las decisiones ejecutivas tomadas en los centros de estudios superiores, sin embargo, se observaron dos competencias: el desarrollo de personas y la gestión de recursos financieros, cuyo comportamiento fue moderado, lo cual constituye una situación a mejorar. En relación con el desarrollo de personas, los hallazgos obtenidos demostraron la necesidad de que la gerencia estratégica enfoque su atención hacia la gestión de los recursos humanos necesarios para ejecutar las actividades del plan estratégico; en este mismo orden de ideas, sobre esta competencia, se determinó la poca frecuencia con que la gerencia educativa evalúa periódicamente el rendimiento del equipo de trabajo, requisito fundamental para el establecimiento de la mejora continua como política organizacional. Del mismo modo, en los resultados obtenidos se hace evidente la necesidad de que la gerencia fortalezca las acciones para obtener los recursos financieros e insumos para la ejecución del plan estratégico, así como establecer medidas de control interno necesarios para optimización de tales recursos dentro de la organización. Ambas situaciones son fundamentales para que el plan estratégico, pasé de ser un ideal a un plan de acción que permitiría el alcance de los objetivos institucionales.
Design and Implementation of Career Counselling System
Authors: Gupta Aashi
Published: August 2021

Career counselling is a most effective aspect of life, it can make one's career or can break it, which eventually leads to a break in life. With the advent of a Covid-19 pandemic, students are not able to choose their career according to worth so guidance/counselling is most imp. This software allows students, passing from the school, to stay in touch and get personal assistance on choosing their colleges and career with the help of seniors or pass-out students. Using this new system, not only the students would be able to differentiate between the pros and cons of different colleges, but they will also be able to get mentorship in a familiar and localized manner. The application will be helpful, informative, and beneficial for a vast majority of students and has the potential of easing student’s lives in diverse ways with the help of their seniors.
Job Portal Indication Using NodeMCU
Authors: Awasthi Ayush
Published: August 2021

At this time jobs are the big reason of concern, it is not possible for the every job seeker to view the newspaper daily. Job seekers have to go to the agency and check the available jobs at the agency .People have to visit different places for the jobs which is much time consuming and costly. So to acquire a one this project consists of a website which is hosted and helpful in finding a job but the Indicator system here gives a boom to this project. A hardware device which works on Node MCU ESP8266 contains a LED for indication as well as a LCD display which will display jobs in seconds on submission , it will helps in reducing workload for the person sitting on admin side as well as we can use it on big screens over the public places for thousands of job seekers.
A Comparative Study on Applications of Novel Drug Delivery System for Herbal Formulations
Authors: Patel Deep
Published: August 2021

For plant actives and extracts, novel drug delivery systems (NDDS) have made great strides in the past few years. Bioactive and plant extracts have been used to create a variety of novel herbal formulations, including polymeric nanoparticles, nanocapsules, liposomes, phytosomes, nanoemulsions, microspheres, transferosomes, and ethosomes. There are a number of advantages that the novel formulations have over conventional formulations, including improved solubility, bioavailability, protection from toxicity, enhancement of pharmacological activity, improved tissue distribution of macrophages, sustained delivery, and protection from physical or chemical degradation, among others. A review of the current state of herbal formulation development, including preparation method, active ingredient type, size, entrapment efficiency, route of administration and biological activity is highlighted in the present work.
COMPARATIVE EVALUATION OF STRUCTURAL AND FUNCTIONAL CHANGES IN THYROID GLAND AFTER IMPLEMENTATION OF INTEGRATED YOGA MODULE (IYM) AS ADJUNCT THERAPY VERSUS CONVENTIONAL LEVOTHYROXINE THERAPY IN HYPOTHYROID FEMALES
Authors: Tiwari M
Published: August 2021

Thyroid disorders have become quite common worldwide over the past few decades. Symptoms of thyroid dysfunction are non-specific and extremely prevalent in the general population. Hypothyroid is the most prevalent thyroid dysfunction and more so in females. Despite the problem being so common, there is no proper treatment modality to control this condition. Many of the as an as have a powerful effect on one or more of the endocrine glands. Practicing some of the specific as an as stimulates the activity thyroid gland and its functions. Hence this study is proposed to generate evidence for yogic practices as an adjunct modality for patients of hypothyroid. The objective of this study is to evaluate the structural and functional changes occurring in patients with hypothyroid as a result of the practice yogic module. The effectiveness of adjunct therapy and the quality of life of patients will also be assessed. 120 female patients of hypothyroid will be randomly allotted to an experimental and control group with 60 patients in each group. Group A will be made to follow the yogic practice module designed along with the conventional treatment whereas Group B will continue with regular conventional treatment. We anticipate that the Yogic module works as an effective adjunct treatment for patients of hypothyroidism and can be used as the first line of treatment in newly diagnosed cases of hypothyroid. Integrated yoga Module will be the new inclusion in the therapeutic model of hypothyroid and also can be studied in different endocrine disorders.
A REVIEW OF AYURVEDIC MANAGEMENT FOR DANDRUFF (DARUNAKA)
Authors: Wairagade S
Published: August 2021

Dandruff is a common scalp disorder affecting almost half of the population. According to ayurveda, dandruff may be correlated to darunaka which is the most common cause of hair loss. Ayurveda classics dealt the different procedures and medications to treat the disease darunaka (dandruff). As a person with dandruff is more likely to feel down on the social ring, it is more of social concern and affects aesthetic value. Under kshudraroga, acharya sushruta referred to darunaka with symptoms such as rukshata, kandu, sphutana twak, etc. Dandruff may occur due to air pollution, water pollution, altered lifestyle, erratic daily routine, poor hygiene, and immune system, sweating, mental stress, etc., which can lead to many infections of bacteria and fungi. It is a common scalp condition that affects approximately half of the pre-pubertal age population and any gender and ethnicity. At some point in their lives, no population in any geographical area would have openly gone by without being affected by dandruff. The line of care for darunaka in the classics is shiroabhyanga, nasya, shirodhara, shirobasti, shirolepa and siravyadha. A review of ayurvedic management for dandruff (darunaka). Ancient acharyas have stated a multidimensional approach towards the management of darunaka. The multidimensional approach of ayurveda towards management of darunaka in the form of shodhana chikitsa, shamana aushadhis, and sthanika chikitsa along with nidana parivarjana gives satisfactory results to the patient.
Classical causal models cannot faithfully explain Bell nonlocality or Kochen-Specker contextuality in arbitrary scenarios
Authors: Pearl J. C. , Cavalcanti E. G.
Published: August 2021

In a recent work, it was shown by one of us (EGC) that Bell-Kochen-Specker inequality violations in phenomena satisfying the no-disturbance condition (a generalisation of the no-signalling condition) cannot in general be explained with a faithful classical causal model---that is, a classical causal model that satisfies the assumption of no fine-tuning. The proof of that claim however was restricted to Bell scenarios involving 2 parties or Kochen-Specker-contextuality scenarios involving 2 measurements per context. Here we show that the result holds in the general case of arbitrary numbers of parties or measurements per context; it is not an artefact of the simplest scenarios. This result unifies, in full generality, Bell nonlocality and Kochen-Specker contextuality as violations of a fundamental principle of classical causality. We identify, however, an implicit assumption in the former proof, making it explicit here: that certain operational symmetries of the phenomenon are reflected in the model, rather than requiring fine-tuned choices of model parameters. This clarifies a subtle but important distinction between Bell nonlocality and Kochen-Specker contextuality.
Potential Zoonotic Gastrointestinal Nematode Infection from Goat in Sumedang
Authors: Fauziah Nisa , Alhafiz Hazel Faras , Nugraha Naufal Fakhri , Krissanti Ita , Hamda Muhammad Ersyad , Faridah Lia
Published: August 2021

Potential of zoonotic gastrointestinal nematode infection from livestock in Indonesia is still often overlooked. Farms with a risk for nematodes infection would create a risk of infecting the local community with zoonotic gastrointestinal nematodes. This study aimed to assess the risk of gastrointestinal nematodes from goats that have zoonotic potential in Cibeureum Wetan, Sumedang, and to identify the incidence of nematodes infection among goats. This was a cross-sectional study conducted in August to November 2019 with a total of 52 samples of feces collected directly from goat’s rectum to prevent soil contamination. Sampling was performed randomly from goats raised at the Agriculture and Self-Sustaining Village Training Center (Pusat Pelatihan Pertanian dan Pedesaan Swadaya, P4S) Simpay Tampomas, Sumedang, Indonesia. The GPS point of the sampling location was recorded. Samples were then examined using the concentration sedimentation method at the Parasitology Laboratory, Faculty of Medicine, Universitas Padjadjaran. Results showed that 22 of 52 samples were positive for gastrointestinal helminth eggs, contained of Bunostomum sp., Strongyloides sp., Haemmonchus sp., Trichostrongylus sp., Toxocara sp. and Trichuris sp. The nematode parasites found are parasites that often infect goats.
Faktor Sosiodemografi dan Riwayat Klinis Malaria Terhadap Insidensi Malaria di Manokwari
Authors: Lusiyana Novyan , Muhajir Nurlaili Farida
Published: August 2021

Malaria is an endemic disease in Manokwari. Malaria transmission was influenced by sociodemographic and geographic factor. However, clinical manifestation of malaria in endemic area was various from asymptomatic, mild to heavy manifestation. The aim of this study was to identify the incidence, sociodemographic, geographic factors, and clinical manifestation of Plasmodium infection in Manokwari. This was a cross sectional study, in August 2019 in two endemic villages, that is Amban and Wosi village, Manokwari district, West Papua. The number of subject involved in this study was 100. 55 subjects came from Amban and 45 from Wosi village. The sociodemographic characteristics of subject such as age, gender, address, education and occupation were recorded. Blood smear examination and Giemsa staining were performed to identify Plasmodium sp on each subject. Results of this study showed that 3% of population were infected by Plasmodium sp. Plasmodium sp. infection. more experienced by men, higher education level and have a job. The demographic and geographic factors were not related with Plasmodium sp. infection (p > 0.05). All of the subjects who infected with Plasmodium sp. show manifestation such as fever, chills, sweating, nausea/vomitus, and diarrhea. The conclusion of this study is highlighted that socio-demographic and geographical factors are not associated with Plasmodium sp. infection, and Plasmodium infection is characterized by clinical symptoms.