bluuebunny/crossref_metadata_2025 huggingface dataset:
Өспүрүмдөрдүн Кибер Зомбулукка Каршы Сезгичтик Деңгээлдерин Аныктоочу Шкаласын Иштеп Чыгуу
Authors: Özerbaş Mehmet Arif , Ysmanova Gulnur
Published: January 2025

Изилдөөнүн максаты өспүрүмдөрдүн кибер зомбулукка каршы сезгичтик деңгээлин аныктоо үчүн жарактуу жана ишенимдүү шкала иштеп чыгуу болуп саналат. Изилдөөнүн фокус-группасын 2023-2024-окуу жылында Бишкек шаарында мамлекеттик мектептердин 7, 8, 9, 10 жана 11-класстарында билим алган 451 окуучу түзгөн. Өспүрүмдөрдүн кибер зомбулукка каршы сезгичтик деңгээлин аныктоочу шкала иштеп чыгуу үчүн эки фокус группадан маалымат топтолгон. Биринчи фокус-группаны түзгөн 281 окуучудан алынган маалыматтар боюнча ачыктоочу фактордук анализ жана ички ырааттуулук анализи жасалган. Үч жумадан кийин экинчи фокус-группадан маалымат чогултулуп, тастыктоочу фактордук анализи жасалган. 16 пункттан турган шкала боюнча тастыктоочу фактордук анализи үчүн 170 окуучудан маалымат чогултулган. Ачыктоочу фактордук анализдин жыйынтыгында “Кибер зомбулукка каршы сезгичтик” шкаласында орун алган пункттар “Коргонуу”, “Адеп” жана “Маалыматтуулук” болуп 3 көмөкчү группага бөлүнгөн. Пункттардын фактордук жүктөрү .47 менен .80 арасында өзгөрөөрү аныкталган. Ал эми ишенимдүүлүк анализинин натыйжасында жалпы шкаланын ишенимдүүлүк деңгээли .73 болуп табылган. Тастыктоочу фактордук анализинин натыйжасында Хи-квадратынын (2) мааниси 181.98, ал эми эркиндик деңгээли (df) 98 болуп табылган. Хи-квадраты/эркиндик деңгээли 1.86 болуп аныкталып, эң сонун болгон көрсөткүчтү көрсөткөн. Шкаланын ылайыктуулук индекстери RMSEA:0.05 болуп эң сонун ылайыктуулук коэффициенттин, калган ылайыктуулук индекстери CFI:0.92, GFI:0.93, AGFI:0.90, IFI:0.92, TLI:0.90 түзүп, жакшы деңгээлдеги ылайыктуулукту көрсөткөн. Жасалган анализдердин жыйынтыгына таянып, иштелип чыккан шкала- өспүрүмдөрдүн кибер зомбулукка каршы сезгичтик деңгээлдерин аныктоодо колдонулуучу ишенимдүү жана жарактуу курал катары колдонула аларын айта алабыз.
Küresel Güvenlik Girişimi’nin Orta Asya’da Çin-Rusya İlişkilerine Etkisi
Authors: Alperen Ümit
Published: January 2025

Çin Devlet Başkanı Xi Jinping’in 2022’de ilan ettiği ‘Küresel Güvenlik Girişimi’ (KGG), Pekin’in bölgesel ve küresel güvenliğe yaklaşımında önemli bir sistematik değişime işaret etmektedir. Küresel düzeyde artan Çin-ABD rekabeti, Rusya’nın Ukrayna’yı işgali, Orta Asya’da ortaya çıkan güvenlik boşluğu gibi gelişmeler Pekin’in küresel ve bölgesel güvenlik yaklaşımını etkilemektedir. Bu gelişmeler karşısında Çin ulusal çıkarlarını korumak için küresel ve bölgesel güvenlik yönetişiminde aktif rol oynamaya çalışmaktadır. Bu çalışma, Çinli karar alıcıların KGG bağlamında neden Orta Asya’da daha etkin bir güvenlik rolü oynamak istedikleri ve bu durumun bölgede Çin-Rusya ilişkilerine muhtemel etkilerini incelemektedir. Bu makale, Rusya’nın Batıyla yaşadığı sorunlar nedeniyle Çin’in Orta Asya güvenliğinde oynamak istediği etkin role sessiz bir rıza gösterse de orta ve uzun vadede iki aktör arasında sorunlara yol açabileceği savunulmaktadır. Bu çerçevede, Çin’in Orta Asya’da potansiyel gelişmiş güvenlik rolüne bütüncül ve detaylı bir bakış açısı geliştirilmesi hedeflenmektedir. Böylece Çin’in Orta Asya’da oynamak istediği güvenlik rolünün de muhtemel sınırları belirlenmeye ve Rusya’yla bölgedeki ilişkilerine nasıl yansıyacağı analiz edilmeye çalışılmaktadır.
Targeting the membrane-proximal domain of CD33 to maximize the efficacy of natural killer cell-based immunotherapies
Authors: Lim Sheryl Y. T. , Cole Frances M. , Laszlo George S. , Lunn-Halbert Margaret C. , Huo Jenny , Li Junyang , Kehret Allie R. , Walter Roland B.
Published: January 2025

Not available.
Tác động của chuyển đổi số tới tăng trưởng kinh tế địa phương tại Việt Nam
Authors: Lê Hải Trung , Trần Trung Dũng , Lương Minh Hương , Lê Minh Thúy
Published: January 2025

Bài viết đánh giá tác động của chuyển đổi số, thể hiện qua chỉ số sẵn sàng cho phát triển và ứng dụng công nghệ thông tin và truyền thông (ICT index) của Bộ Thông tin và Truyền thông, đến tăng trưởng kinh tế tại các tỉnh thành Việt Nam. Sử dụng dữ liệu dạng bảng của 63 tỉnh thành tại Việt Nam trong giai đoạn 2018-2022, kết quả cho thấy chuyển đổi số có tác động tích cực đối với tăng trưởng kinh tế của các tỉnh thành trong giai đoạn nghiên cứu. Cụ thể, việc gia tăng mức độ sẵn sàng về nguồn nhân lực và ứng dụng công nghệ thông tin trong khu vực công cho thấy tác động tích cực tới tốc độ tăng trưởng kinh tế của các tỉnh thành. Dựa trên các kết quả định lượng, nhóm nghiên cứu đưa ra một số hàm ý chính sách đối với các cơ quan quản lý nhà nước, chính quyền địa phương và các doanh nghiệp.
Pengaruh Customer Experience dan Persepsi Harga terhadap Minat Beli Ulang Aplikasi Streaming Disney+ Hotstar
Authors: Rahmadhani Novia Rizky , Wardhani Nuruni Ika Kusuma
Published: January 2025

The research intends  to explore as well as assess the impact of customer experience also price perception on repurchase interest for the Disney+ Hotstar streaming service. This study was conducted with 110 respondents, all of whom were Disney+ Hotstar customers living in Surabaya. The purposive sampling approach was employed, and the study was quantitative. The data will be measured and analyzed using SmartPLS. The study explains that: (1) Customer Experience has a significant impact on repurchase interest for the Disney+ Hotstar streaming service, and (2) Price Perception positively influences repurchase interest.
ANALISIS BRANDED CONTENT VIDEO (BCV) SEBAGAI STRATEGI MARKETING UNTUK GENERASI Z DI JABODETABEK
Authors: Jannah Fani Nur , Amorza Sabrina , Pinontoan Vintasya Hilda Kauri
Published: January 2025

This study aims to analyze the impact of branded content videos on the purchasing interest of Generation Z. This research is conducted because, according to BPS, Generation Z will become the most populous generation by 2030, a phenomenon often referred to as the demographic bonus. Therefore, a study is needed to understand the characteristics of Generation Z to develop a digital marketing strategy, particularly in creating branded content videos (BCV) on social media. This research uses a qualitative method with descriptive analysis. The unit of analysis is Generation Z individuals who frequently use social media for shopping and are often exposed to promotional videos of products marketed on social media. The results of this study show that branded content videos that are relatable, high-quality, objective, organic, and beneficial are more appealing to Generation Z than videos by influencers or celebrities promoting a product, especially evident in advertising videos that overtly market products.
EVALUATION OF THE EFFECTIVENESS RATIO FOR THE ALLOCATION OF VILLAGE FUNDS
Authors: Andriyani Fitriya , Ardhiarisca Oryza , Pramista Titis Wangi Anggun
Published: January 2025

Purpose: The purpose of this study is to evaluate how well ADD is working in Gentong Village, Taman Krocok District, Bondowoso Regency, to execute village development. Methods: The method used for this research is qualitative research with a case study approach. Analysis data: The data analysis technique uses the effectiveness ratio number. Result and discussions: The results showed that the use of ADD in Gentong Village, Taman Krocok District, was effective in increasing village development. Conclusion: ADD has been used to build bridges, roads, public toilets (MCK), and the Clean Water/Pamsimas Program. However, there are still challenges in using ADD in Gentong Village, Taman Krocok District, such as disagreements in the field and delays in center funding disbursements. Based on the results of this study, it is suggested that the village government and the community increase their participation in the process of planning and monitoring the use of ADD. In addition, efforts are also needed in more effective ADD financial management and increased coordination between the village government and other stakeholders.
Langer’s Axillary Arch: A Frequently Missed Axillary Anomaly That Can Alter the Outcome of Breast Cancer Management- Case Series
Authors: Alazhri Jamila , Al-Malki Noor , Al-Ajmi Sara , Lathy Hala El
Published: January 2025

The axillopectoral muscle known as Langer's axillary arch (LAA), is considered the most common anatomical variation of the axilla. The muscular fibers typically originate from latissimus dorsi (LD) muscle, crossing over the axillary neurovascular bundle to insert deep to the insertion of pectoralis major muscle. Although it is frequently missed, surgeons must be attentive to its existence during axillary surgery or LD flap breast reconstruction. LAA fibers should be excised to expose the axillary nodes, vessels and nerves. Failure to identify this anomaly can jeopardize the LD flap vascularity, and can reduce the accuracy of retrieving sentinel lymph nodes, increase the false negative rate, and result in under staging and/or under treatment of the axilla in breast cancer patients. Consequently, altering the decision for adjuvant treatment like chemotherapy or radiation therapy, which would affect the patient’s survival outcome.

In the present series, we report 7 cases of the LAA, and describe the surgical findings during axillary surgery for each case, paying special attention to the tips to identifying LAA, its different subtypes, and its clinical implication in breast cancer patients, and summarize existing literature.
Risk Factors Associated with the Onset of Diabetes Mellitus in Patients with A History of Gestational Diabetes at The University Hospital of Kinshasa
Authors: A Tandu Umba , R Mbungu Mwimba , P Kahindo Muyayalo , A Mbangama Muela , J Lumaya Ambis , N Mwimba Mbungu , Sambwa Kelele Goy , P Lukunda Diansambu , B Kinkenda Nsiangangu
Published: January 2025

Background: Gestational diabetes mellitus (GDM) is a disorder of glucose tolerance occurring or first diagnosed during pregnancy, whatever the treatment required and its evolution after delivery. Its prevalence varies between 5 and 17% depending on the setting. 15 to 60% of those who develop gestational diabetes progress to type 2 diabetes, and are therefore at major risk of developing type 2 diabetes, hence the importance of identifying the risk factors associated with this conversion, so that preventive measures can be taken.

Objectives: This study aims to identify the risk factors associated with the onset of type 2 diabetes in women with a history of gestational diabetes at the University Hospital of Kinshasa.

Methods: This study will be a retrospective cohort conducted at the University Hospital of Kinshasa among women with a history of gestational diabetes from January 2013 to December 2023. Women with a history of gestational diabetes will be recruited from the delivery room registers at University Hospital of Kinshasa. Their data will be collected in their files, and they will be contacted for type 2 diabetes screening. Delivery and breastfeeding data 6 weeks after delivery, anthropometric data, physical activity, diet and rhythm will be analysed.

Conclusion: At the end of this study, the rate and time of conversion of gestational diabetes to type 2 diabetes, as well as the factors associated with this outbreak, will be known in our setting, providing us with variables on which we can act to reduce the progression of gestational diabetes to diabetes mellitus.
The role of large language models in the peer-review process: opportunities and challenges for medical journal reviewers and editors
Authors: Lee Jisoo , Lee Jieun , Yoo Jeong-Ju
Published: January 2025

The peer review process ensures the integrity of scientific research. This is particularly important in the medical field, where research findings directly impact patient care. However, the rapid growth of publications has strained reviewers, causing delays and potential declines in quality. Generative artificial intelligence, especially large language models (LLMs) such as ChatGPT, may assist researchers with efficient, high-quality reviews. This review explores the integration of LLMs into peer review, highlighting their strengths in linguistic tasks and challenges in assessing scientific validity, particularly in clinical medicine. Key points for integration include initial screening, reviewer matching, feedback support, and language review. However, implementing LLMs for these purposes will necessitate addressing biases, privacy concerns, and data confidentiality. We recommend using LLMs as complementary tools under clear guidelines to support, not replace, human expertise in maintaining rigorous peer review standards.
ON THE ISSUE OF THE APPLICATION OF MANDATORY METHODS OF PROTECTING THE RIGHT OF OWNERSHIP OF REAL ESTATE IN CIVIL CIRCULATION
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russia, GORBUNOVA E.S. , KOROTKOVA M.V.
Published: January 2025

The purpose of the research. The article deals with the problems of applying mandatory methods of protecting the ownership of real estate in the conditions of the existence of the principle of their priority. The essence, purpose and result of the application of compulsory claims in the protection of real estate rights are analyzed, doctrinal approaches to the definition of lawsuits of obligations, their correlation (competition) with property lawsuits are also considered. The purpose of the study is to establish and identify the features of mandatory claims, as well as the possibility of their application in certain cases, for example, in the case of the return of property to the lessor upon termination of the lease agreement. It is necessary to solve the problem of subordination of property and mandatory requirements, since there is a "deformation" of traditional property remedies in the Russian legal system.

Results. As a result of the conducted research, the author comes to the conclusion, that despite the consolidation of the principle of the priority of the law of obligations, judicial practice requires the development of clear criteria that make it possible to distinguish between proprietary and binding methods of protecting property rights. In this regard, the author proposes to provide such criteria concerning the method of violation or challenge of the right, the nature of the violated right, the observance of the right to claim, the properties of the subject of the dispute. The author concludes that it is necessary to introduce the institution of ownership protection into Russian legislation, aimed at restoring the violated situation and not requiring a complex process of proving ownership of real estate.
CURRENT TRENDS AND PROSPECTS FOR THE DEVELOPMENT OF THE FOREIGN EXCHANGE MARKET OF THE RUSSIAN FEDERATION IN THE CONTEXT OF SANCTIONS PRESSURE
Authors:   Russian Academy of National Economy and Public Administration under the President of the Russian Federation, Moscow, Russian Federation, IEVLEVA YEVGENIA O. , DROBYSHEVSKY SERGEY M. , ANISHCHENKO EVGENY V. ,   Lomonosov Moscow State University, Moscow, Russian Federation
Published: January 2025

The article examines the factors, features and trends in the development of foreign trade payments as an integral part of the global foreign exchange market in the context of global financial imbalances, deglobalization processes and the sanctions regime against Russia. Special attention is paid to alternative calculation mechanisms in foreign trade transactions, as well as to the characteristics of the channels of influence of the current conditions of the functioning of the Russian foreign exchange market on the strategy of monetary policy. Given the fact that the development of foreign trade payments has become one of the key areas of financial market development, it is extremely important to actively work with foreign regulators and market participants, based on the priority of building foreign economic activity on market principles, in terms of financial services activities, giving priority to the use of the Russian ruble and other national currencies in international settlements. The article also analyzes and identifies, in the author's opinion, the most effective methods of work to overcome existing limitations and create conditions for the development of an international settlement system that fully meets the challenges and needs «in the era of modern times».
THE ROLE OF THE STRATEGY FOR THE DEVELOPMENT OF THE MINERAL RESOURCE BASE OF THE RUSSIAN FEDERATION IN IMPROVING STRATEGIC PLANNING OF SUBSOIL USE: LEGAL ASPECT
Authors:   National University of Oil and Gas «Gubkin University», Moscow, Russian Federation, AGAFONOV VYACHESLAV B.
Published: January 2025

The article is devoted to the study of the role of the Strategy for the Development of the mineral resource base of the Russian Federation until 2050, approved by Decree of the Government of the Russian Federation dated 07/11/2024 No. 1838-r, in improving the legal support for strategic planning of subsurface use in modern conditions of sanctions restrictions applied to the Russian Federation. As a result of the analysis of the provisions, norms, principles, meanings and goals of the new Strategy, the conclusion is proved that strategic planning in the field of subsoil use is currently developing very dynamically, allowing for all possible challenges, risks and threats to be taken into account, which is one of the most effective indicators of achieving the basic goals of state strategic planning. Meanwhile, it is noted that the implementation of the new Strategy for the development of the mineral resource base of the Russian Federation until 2050 is impossible without a conceptual revision of existing documents of state strategic planning in the field of energy development, environmental protection and environmental safety, including in the Arctic zone of the Russian Federation, as well as in the field of prevention and liquidation of natural and technogenic nature.
Mempertahankan Karakter Budaya Islam Masyarakat Desa Ujungwatu Donorojo Jepara Di Tengah Globalisasi
Authors: Muhammad Jodi Prasetiyo  , Abi Amar Zubair  , Dany Miftah M.Nur  , Rofiq Faudy Akbar
Published: January 2025

Perkembangan pesat di era revolusi industri 5.0, yang dikenal sebagai Society 5.0, membawa dampak signifikan terhadap berbagai aspek kehidupan, termasuk budaya dan agama. Penelitian ini bertujuan untuk mengeksplorasi dampak revolusi industri 5.0 dan globalisasi terhadap karakter budaya Islam di Desa Ujungwatu, Donorojo, Jepara. Permasalahan yang diangkat mencakup bagaimana masyarakat setempat beradaptasi dengan perubahan yang terjadi akibat globalisasi, serta bagaimana mereka mempertahankan nilai-nilai budaya Islam di tengah arus modernisasi. Metode yang digunakan dalam penelitian ini adalah etnografi, yang melibatkan pengumpulan data melalui observasi, wawancara, dan analisis dokumen untuk memahami praktik budaya dan keagamaan masyarakat. Hasil penelitian menunjukkan bahwa masyarakat Desa Ujungwatu menunjukkan sinkretisme antara ajaran Islam dan budaya lokal, yang tercermin dalam berbagai ritual dan tradisi, seperti sedekah bumi dan sedekah laut. Selain itu, arsitektur dan seni Islam di desa ini juga mencerminkan pengaruh lokal yang kuat. Masyarakat berupaya mempertahankan karakter budaya Islam melalui pendidikan yang komprehensif, akulturasi yang bijaksana, dan sikap kritis terhadap perubahan. Meskipun globalisasi membawa tantangan, masyarakat Desa Ujungwatu berhasil menjaga keseimbangan antara tradisi Islam dan modernitas, serta memastikan bahwa nilai-nilai budaya Islam tetap relevan di era yang terus berubah.
A community’s practice: A case study of professional development among vocational and arts teachers
Authors: Annerberg Anna , Göthberg Martin
Published: January 2025

Since considerable resources are invested in the professional development of teachers, there is an urgent need to investigate various models. In Sweden, schools often use thoroughly structured continuing professional development packages for teachers – with pre-set goals, methods, and questions to discuss. The aim of the present study is to gain knowledge about how professional development is constituted in a specific teacher community, within the context of teaching and assessing practical knowing. A group of arts and vocational teachers at a Swedish upper secondary school voluntarily engaged in a year-long developmental Teacher Community (TC), in which explorative talk about teaching is central. Podcasts created in teams of two after peer observations and group meetings are analysed at multiple levels to identify what they talk about and how. Based on the analyses of the explorative discussions, we used the theory of Communities of Practice to understand specific features of the practice of the teachers’ professional development. The main result is that, while the teachers are building a strong common platform for professional development through their TC, the learning processes are solitary journeys and their individual professional responsibility. One of the characteristics of the interaction within the TC is the absence of critical approaches to peers, which is often prompted as a prerequisite by previous research. Instead, with esteem as characteristic for the explorative discussions, the TC demonstrates complex reasoning on professional identity and an eagerness to learn more from others about teaching practical knowing. Finally, we suggest alternatives to overly structured CPD packages with pre-set goals and methods.
Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens
Authors: Zhang Shi-Yan , Zhuo Ying , Li Bu-Ren , Jiang Ying-Ying , Zhang Jie , Cai Na , Yang Lin
Published: January 2025

Background

This study aimed to assess the distribution of bacteremia pathogens in elderly patients, examine the impact of gender on pathogen distribution, and evaluate the predictive value of routine blood parameters for diagnosing bacteremia.

Methods

A retrospective analysis was conducted on 151 elderly patients (≥60 years old) admitted to Fuding Hospital, Fujian University of Traditional Chinese Medicine between October 2022 and June 2023. Comprehensive routine blood tests and blood cultures were performed. The diagnostic efficacy of routine blood parameters, including white blood cell (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red blood cell distribution width (RDW), was evaluated using receive operating characteristic (ROC) curve analysis. Patients were categorized into either the culture-positive group (82 cases) or the culture-negative group (69 cases) according to blood culture results.

Results

No significant differences in age and gender were found between the culture-positive and culture-negative groups. The primary bacterial pathogens of bacteremia in the elderly were Escherichia coli, Klebsiella pneumoniae and Streptococcus. Elderly female patients demonstrated a significantly higher culture positivity rate for E. coli compared to their male counterparts (P = 0.021). The areas under the ROC curve (AUC) for the four parameters were as follows: WBC, 0.851 (95% confidence interval (CI) 0.790 - 0.912); NLR, 0.919 (95% CI 0.875 - 0.963); PLR, 0.609 (95% CI 0.518 - 0.700); and RDW was 0.626 (95% CI 0.563 - 0.717).

Conclusions

E. coli was identified as the predominant pathogenic microorganism causing bacteremia in the elderly, with a significantly higher culture positivity rate among female patients. Routine blood parameters (WBC, NLR, PLR, and RDW) demonstrated a predictive potential for diagnosing bacteremia in elderly patients.
The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects
Authors: Zhang Sijie , Bian Wenxuan , Wang Yan , Shen Min , Qian Yu , Dai Hao , Zheng Shuai , Fu Qi , Xu Kuanfeng , Yang Tao , Jiang Hemin
Published: January 2025

Objective

This study aims to investigate the associations between MTNR1B rs724030 A>G variant and prediabetes risk, along with their correlations with clinical features, including plasma glucose and serum insulin levels during oral glucose tolerance test (OGTT), islet function, insulin resistance, and plasma lipid levels. In particular, we investigated whether there are sex dimorphisms in the impact of this variant on islet function/insulin resistance.

Methods

We included 3415 glucose-tolerant healthy and 1744 prediabetes individuals based on OGTT. Binary logistic regression was performed to evaluate the relationships between rs724030 in MTNR1B and prediabetes under the additive model. Additionally, multiple linear regression was utilized to investigate the associations between this variant and glycemic-related quantitative traits and lipid levels.

Results

While no association was observed between the rs724030 variant in MTNR1B and prediabetes risk in the overall cohort (P > 0.05), we found the G allele of this variant was associated with higher fasting and 30-minute plasma glucose levels, decreased Insulinogenic Index (IGI), and oral disposition index (DIo) (P = 0.009, 0.001, 0.001, and 0.007, respectively) in the normal glucose tolerance (NGT) individuals with normal BMI levels. Furthermore, we also found significant associations between this variant and IGI, corrected insulin response (CIR), and DIo (All P < 0.001) in female individuals whose waist-to-hip ratio (WHR) is greater than 0.85, with considerable heterogeneity (Phet = 0.009, 0.030, and 0.049, respectively) to male participants in the NGT individuals, but not in the impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) individuals. Additionally, no association was observed between this variant and insulin clearance (All P > 0.05).

Conclusions

The MTNR1B rs724030 variant contributes to glycemic traits and islet function, and its effects have sex dimorphisms in the NGT individuals after stratifying by WHR. All these findings provide a basis for accurately assessing islet function in healthy populations and offer a new perspective on precision prevention.
Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity
Authors: Dai Yuanquan , Yuan Zheng , Fan Weisen , Lin Zhiheng
Published: January 2025

Patients with adenomyosis not only experience a decrease in quality of life as a result of dysmenorrhea and severe monthly flow but they are also rendered infertile. Pregnancy rates are still low among women with adenomyosis, even with assisted reproduction. According to the current study, endometrial receptivity is primarily responsible for the lower conception rate among patients with adenomyosis. Decidualization of endometrial stromal cells is the fundamental requirement for endometrial receptivity and the maintenance of a normal pregnancy, even though endometrial receptivity is made up of a variety of cells, including immune cells, endometrial epithelial cells, and endometrial stromal cells. Our overview reveals that endometriosis deficiencies are present in patients with adenomyosis. These flaws may be linked to aberrant pathways in endometrial stromal cells, such as PI3K/Akt, JAK2/STAT3, and hedgehog. Correcting the abnormal expression of molecules in endometrial stromal cells in the endometrium of patients with adenomyosis may become the focus of research to improve endometrial receptivity and increase the pregnancy rate.
The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function
Authors: Majumdar Shubhabrata , Echelibe Hilda , Bettini Maria , Bettini Matthew L.
Published: January 2025

Introduction

Chimeric antigen receptor (CAR) expressing T-cells have shown great promise for the future of cancer immunotherapy with the recent clinical successes achieved in treating different hematologic cancers. Despite these early successes, several challenges remain in the field that require to be solved for the therapy to be more efficacious. One such challenge is the lack of long-term persistence of CD28 based CAR T-cells in patients. Although, CD28 based CAR T-cells elicit a robust acute anti-tumor response, they are more prone to early exhaustion, terminal differentiation and cell death due to their strong signaling patterns. Hence attenuation of signaling strength in CD28 based CARs is an accepted strategy to improve long-term CAR T-cell function and persistence in patients. Previous studies with the conventional T-cell receptor (TCR) have suggested that manipulation of CD3 immunoreceptor tyrosine-based activation motif (ITAM) sequences can alter TCR signaling strength. Based on these studies, we have designed 2nd generation murine anti-CD19 CD28 based CARs with restricted CD3ζ ITAM sequence diversity while maintaining a multiplicity of three. They are called ζAAA, ζBBB and ζCCC based on which CD3ζ ITAM they express. The goal of the study is to understand the non-redundant signaling properties of the individual CD3ζ ITAMs and their effect on CAR T-cell function. We hypothesized that the individual CD3ζ ITAMs will exhibit unique signaling properties in the ITAM restricted CARs which may allow for optimization of CAR signaling and improve CAR T-cell persistence and function.

Method

We subjected the ITAM restricted CAR T cells to various conditions of in vitro stimulation using CD19+ tumor cells or CD19-coated magnetic beads. Immunoblotting and flow cytometry based Ca2+ signaling assays were used to quantify signaling differences. Functional differences were studied using in vitro cytotoxicity, degranulation and cytokine expression assays. CAR T cell exhaustion and differentiation were studied using an in vitro exhaustion assay.

Results

We observed that ζAAA CARs had stronger signaling strength compared to ζBBB and ζCCC CARs. The signaling differences were reflected in their functional activation profiles with T-cells expressing ζAAA CARs having a strong activation profile and ζCCC CARs having a weak activation profile. ζCCC CAR T cells were less prone to differentiation and exhaustion.

Discussion

Since, weaker signaling ζCCC CARs favored less cell death, exhaustion and differentiation, they might be better candidates for improving long term survival and persistence of CAR T cells in patients.
Case report: Detection and treatment of a rare submucosal gland duct adenoma of the esophagus
Authors: Zhou Yu , He Daoxing , Huang Zhigang , Chen Zhaoyi , Zhou Zheng , Duan Hui , Xu Jie
Published: January 2025

This article reports a rare case of esophageal submucosal gland duct adenoma (ESGDA). The patient was found to have this tumor after undergoing endoscopy in an outpatient clinic due to occasional tingling while eating. White light endoscopy revealed the tumor as a dumbbell-shaped bulge, and ultrasound endoscopy revealed it as a hypoechoic mass located in the submucosal layer. The tumor was successfully resected by endoscopic mucosal dissection with no postoperative recurrence and a good prognosis. In conjunction with literature analysis, the diagnosis of ESGDA relies mainly on endoscopic and pathologic examinations, and its histologic features are highly specific. Despite the rarity of ESGDA, accurate histologic evaluation is essential to avoid misdiagnosis. Complete endoscopic resection is an effective treatment with a favorable long-term prognosis. Further studies remain necessary to reveal its pathogenesis.
Mapping QTLs for early leaf spot resistance and yield component traits using an interspecific AB-QTL population in peanut
Authors: Gomis J. , Sambou A. , Nguepjop J. R. , Tossim H. A. , Seye M. , Djiboune R. , Sambakhe D. , Loko D. , Conde S. , Alyr M. H. , Bertioli D. J. , Leal-Bertioli S. C. M. , Rami J. F. , Kane A. , Fonceka D.
Published: January 2025

Early leaf spot (ELS), caused by Passalora personata (syn. Cercospora arachidicola), is a highly damaging peanut disease worldwide. While there are limited sources of resistance in cultivated peanut cultivars, wild relatives carry alleles for strong resistance, making them a valuable strategic resource for peanut improvement. So far, only a few wild diploid species have been utilized to transfer resistant alleles to cultivars. To mitigate the risk of resistance breakdown by pathogens, it is important to diversify the sources of resistance when breeding for disease resistance. In this study, we created an AB-QTL population by crossing an induced allotetraploid (IpaCor1), which combines the genomes of the diploid species Arachis ipaënsis and A. correntina, with the susceptible cultivar Fleur11. A. correntina has been reported to possess strong resistance to leaf spot diseases. The AB-QTL population was genotyped with the Axiom-Arachis 48K SNPs and evaluated for ELS resistance under natural infestation over three years in Senegal. Marker/trait associations enabled the mapping of five QTLs for ELS resistance on chromosomes A02, A03, A08, B04, and B09. Except for the QTL on chromosome B09, the wild species contributed favorable alleles at all other QTLs. One genomic region on chromosome A02 contained several relevant QTLs, contributing to ELS resistance, earliness, and increased biomass yield, potentially allowing marker-assisted selection to introduce this region into elite cultivars. This study’s findings have aided in diversifying the sources of resistance to ELS disease and other important agronomic traits, providing another compelling example of the value of peanut wild species in improving cultivated peanut.
Single nucleotide polymorphism-based visual identification of Rhodiola crenulata using the loop-mediated isothermal amplification technique
Authors: Hao Li , Shi Xin , Wen Shiyu , Yang Caiye , Chen Yaqi , Yue Samo , Chen Jiaqiang , Luo Kexin , Liu Bingliang , Sun Yanxia , Zhang Yi
Published: January 2025

Introduction

Rhodiola crenulata (Hook.f. & Thomson) H.Ohba, a member of the Crassulaceae family, is a traditional Chinese medicine recognized as the original source of Rhodiolae Crenulatae Radix et Rhizoma in the 2020 edition of the China Pharmacopoeia. It has been widely used in both Asia and Europe to enhance stress resistance and reduce fatigue. However, the classification of Rhodiola species can lead to confusion, raising safety concerns in the herbal medicine market.

Methods

The cleaved amplified polymorphic sequence (CAPS) RT-PCR was used to identify the single nucleotide polymorphism (SNP) sites, based on which the loop-mediated isothermal amplification (LAMP) was employed to develop the method in Rh. crenulata identification. The specific loop backward primers, reaction temperature, reaction time, and color indicators were screened and optimized.

Results

Single nucleotide polymorphism (SNP) sites were identified between Rh. crenulata and two closely related species. Based on the identified SNP sites, the optimal real-time fluorescence LAMP system to identify Rh. crenulata was constructed with the most efficient specific loop backward primers, reaction temperature. The final detection system exhibited a sensitivity of up to 1,000 copies of the target DNA, maintaining a constant reaction temperature of 62°C within 35 minutes. To facilitate visualization, we incorporated two color indicators, hydroxy naphthol blue (HNB) and neutral red (N-red), into the reaction system.

Discussion

Collectively, we developed a simple, rapid, specific, sensitive, and visible method to distinguish Rh. crenulata from other two Rhodiola species and Rh. crenulata hybrids. This approach has significant potential for applications in pharmaceutical industry.
Takeaway food consumption and depressive symptoms in Chinese university students: mediating effects of physical activity
Authors: Tan Jianyu , Wang Rui , Su Zhewei , Kong Yiting , Ran Pan , Greenshaw Andrew , Hong Su , Zhang Qi , Wang Wo , Ai Ming , Kuang Li
Published: January 2025

Background

The consumption of takeaways is becoming increasingly prevalent. Despite this, the relationship between takeaway food consumption and depressive symptoms in Chinese populations has not been clarified. Furthermore, the factors that mediate the association between takeaway frequency and depressive symptoms are unknown.

Methods

Questionnaires were employed to collect data from 6,417 new students at Chongqing Medical University in the autumn of 2023, including sociodemographic information, takeaway frequency, physical activity levels (measured by the International Physical Activity Questionnaire Short Form), and depressive symptoms (measured by the Patient Health Questionnaire-9). Multiple linear regression and mediation analysis were performed. Multiple imputations were used to fill in missing data through sensitivity analyses.

Results

Among 6417 participants, 2,606 (40.6%) students ordered takeaway at least once a week, with 235 (3.7%) of them ordering takeaway food every day. Takeaway frequency was significantly associated with depressive symptoms (β=0.034, P=0.006), and physical activity partially mediated this relationship (95% bootstrap confidence interval=0.0024, 0.0371).

Conclusions

The study highlights the negative relationship between takeaway frequency and emotional well-being, emphasizing the need to focus on the emotional health of frequent takeaway food consumers. Moreover, our study suggests that increased physical activity may alleviate takeaway-induced mood-related outcomes.
Impact of Low Light on Photosynthetic Characteristics, Antioxidant Activity, and Yield of Brassica napus L.
Authors: Hu Yue , Javed Hafiz Hassan , Liu Li , Liu Yalong , Yang Xiaohui , Xu Feifei , Liu Ying , Peng Xiao , Wu Yongcheng
Published: January 2025

Low light is an abiotic stress that has a significant impact on crop growth. However, the impact of low light on rapeseed yield has not been well documented. Our study aims to examine the potential effects of low light on the photosynthesis antioxidant capacity and yield composition of leaves by simulating low light environments. According to the study results, low light reduces key photosynthetic enzymes and sucrose synthase activity in rapeseed leaves, leading to a decrease in leaf carbohydrate accumulation. The reduced number of pods per plant and the number of pods per grain are the direct factors leading to the decrease in rapeseed grain yield, while the increase in grain weight compensates for some of the yield loss. In addition, low light increased the content of malondialdehyde in leaves and altered the activities of catalase (CAT) and superoxide dismutase (SOD). Low light inhibits photosynthesis in leaves, reduces leaf productivity, and leads to a decrease in yield. High-yielding varieties have stronger antioxidant capacity and lower production of malondialdehyde. By revealing the effects of low light on the photosynthesis and antioxidant capacity of rapeseed leaves, this studyprovide new insights into the composition of low light affecting rapeseed grain yield and explain significant guidance for the planting and management of different rapeseed varieties in low light areas.
The Erythrocyte Sedimentation Rate (ESR) in Veterinary Medicine: A Focused Review in Dogs and Cats
Authors: Diamanti Daniela , Pieroni Carolina , Pennisi Maria Grazia , Marchetti Veronica , Gori Eleonora , Paltrinieri Saverio , Lubas George
Published: January 2025

The erythrocyte sedimentation rate (ESR) measures the rate at which erythrocytes aggregate and sediment in a fixed time in an anticoagulated blood tube and is expressed as a speed (mm/h). The ESR is still widely used in human medicine mainly as a modified or alternate method to the original Westergren. In veterinary medicine, it was employed in the 1940s–1960s after which it was gradually abandoned or rarely employed. More papers using the Westergren method have been published in dogs rather than in cats. In recent years, the test has regained importance. This narrative review describes the principle of ESR, which is related to the increase in a few acute response proteins such as fibrinogen, immunoglobulin M, and α2-macroglobulin which act to aggregate RBCs. Reference intervals were established for dogs and cats for the original and modified Westergren method. The ESR is mainly used to detect inflammatory conditions derived from infection, urinary or orthopedic disorders, and also miscellaneous diseases. The application of the modified ESR is supported by appropriate reference intervals; however, further studies are needed to assess the influence of age, sex, and breed both for dogs and cats.
A 32 μm2 MOS-Based Remote Sensing Temperature Sensor with 1.29 °C Inaccuracy for Thermal Management
Authors: Yang Ruohan , Banahene Kwabena Oppong , Gadogbe Bryce , Geiger Randall , Chen Degang
Published: January 2025

This paper introduces a compact NMOS-based temperature sensor designed for precise thermal management in high-performance integrated circuits. Fabricated using the TSMC 180 nm process with a 1.8 V supply, this sensor employs a single diode-connected NMOS transistor, achieving a significant size reduction and improved voltage headroom. The sensor’s area is 32 µm2 per unit, enabling dense integration around thermal hotspots. A novel voltage calibration method ensures accurate temperature extraction. The measurement results demonstrate three-sigma errors within ±0.1 °C in the critical range of 75 °C to 95 °C and +1.29/−1.08 °C outside this range, confirming the sensor’s high accuracy and suitability for advanced thermal management applications.
Healthcare Workers’ Attitudes Toward Older Adults’ Nutrition: A Descriptive Cross-Sectional Study in Italian Nursing Homes
Authors: Zanini Milko , Catania Gianluca , Di Nitto Marco , Delbene Lara , Ripamonti Stefania , Musio Maria Emma , Bagnasco Annamaria
Published: January 2025

Background: Malnutrition is a widespread issue among older people, significantly impacting health outcomes. Nutritional interventions can improve health, but their success often depends on the attitudes and knowledge of healthcare workers. Aim: This study assesses healthcare workers’ attitudes toward older people’s nutrition using the validated Italian version of the Staff Attitudes to Nutritional Nursing Geriatric care scale (SANN-G), focusing on staff in nursing homes in Northern Italy. Methods: A cross-sectional study was conducted with 1789 healthcare workers from 41 facilities. The SANN-G questionnaire measured attitudes across five dimensions: nutritional norms, habits, assessment, intervention, and individualization. Data were collected online and on paper, with descriptive and inferential statistical analyses (chi-square and ANOVA) performed using R software (R-4.4.2 for Windows). Results: Most healthcare workers were female (68.59%) and aged 41–50 (33.31%), with nursing assistants comprising 35.83%. Only 23.48% scored positively on the SANN-G scale, with most exhibiting neutral or negative attitudes. Healthcare workers who attended a malnutrition course were more likely to exhibit positive attitudes toward nutrition, particularly in the dimension of norms, assessment, intervention, and individualization. Younger healthcare workers, with the role of nurses and who attended a course on malnutrition, were more likely to have positive attitudes, while older healthcare workers and with the role of physicians tended to show neutral or negative attitudes. Conclusions: Education on malnutrition improves healthcare workers’ attitudes toward older adults’ nutrition, especially among younger nurses. The low percentage of positive attitudes (23.48%) underscores the need for broader education programs to enhance nutritional care quality.
Effects of Resistance Training on Executive Functions of Cognitively Healthy Older Adults: A Systematic Review and Meta-Analysis Protocol
Authors: Jerez-Salas Felipe , Campos-Jara Christian , Araya Sierralta Sergio , Jerez-Mayorga Daniel , Ramirez-Campillo Rodrigo , Contreras-Díaz Guido , Carrasco-Alarcón Vanessa , Martínez-Cortés Hugo , Arellano-Roco Cristián , Hernández-Cifuentes Victoria , Contreras-Osorio Falonn
Published: January 2025

Background/Objectives: Aging involves a series of changes in non-pathological age-related conditions, some of which impact the cognitive functioning of older adults. Executive functions are cognitive skills that are often affected in this process, although they have been shown to improve after physical exercise interventions. This protocol aims to describe the procedures that will be carried out in a systematic literature review, including a meta-analysis of the effects of resistance interventions on the main dimensions of executive function in cognitively healthy older adults compared to active or passive control groups. Methods: The PRISMA-P guidelines will be followed. Eligibility criteria will be organized based on the PICOS strategy (older adults with normal cognition ≥60 years; chronic resistance interventions ≥4 weeks; active or passive control group; direct measures of executive function). The PubMed, EBSCO, Scopus, and Web of Science databases will be used. The risk of bias and quality of evidence will be measured using RoB2 and GRADE, respectively. The DerSimonian–Laird random effects model will be used for the meta-analysis. The effect size will be calculated using Hedges’ g with a 95% confidence interval and p < 0.05 to indicate statistical significance. Discussion: The results of the proposed review may be useful to justify the design and implementation of treatment plans based on resistance training for the prevention and management of cognitive changes typical of aging among older adults. PROSPERO registry: CRD42024571127.
The Effects of the Mamanet Cachibol League Intervention Program on Perceived Health Status, Mental Health, and Healthy Lifestyle Among Arab Women
Authors: Eines Karin , Tesler Riki , Birk Ruth , Giladi Ariela , Dunsky Ayelet , Alian Nada , Gonen Limor , Barak Sharon
Published: January 2025

Background: The Israeli Mamanet Cachibol League (MCL) is a community-oriented athletic program serving mothers through non-competitive recreational sports participation. This study aimed to assess the effects of the MCL on perceived health status, mental health (happiness, depression, social capital), and healthy lifestyle behaviors (physical activity and nutrition). Methods: This is an experimental study with a sample of 231 women (174 in the experimental group and 57 in the control). Participants completed questionnaires in November 2023 (T1) and then in August 2024 (T2). The questionnaire included questions on sociodemographic characteristics, perceived health status, mental health (happiness, depression, social capital), and healthy lifestyle behaviors (physical activity and nutrition). Results: At T1, the MCL participants reported better mental health (higher subjective happiness and social capital and lower depressive symptoms) than the control group. Over time, participation in the MCL led to significant improvements in mental health (reductions in depression and increases in subjective happiness and social capital). The participants showed substantial improvements in healthy lifestyle behaviors, with moderate effect sizes (effects size > 0.5) observed across these areas. Sociodemographic factors influenced the outcomes, with variations in health perception and physical activity linked to marital status and education level. Conclusions: Participation in the MCL program was associated with better mental health at baseline and significantly improved over time compared to the control group. The MCL participants also showed gains in healthy lifestyle behaviors, highlighting the importance of tailored interventions.