bluuebunny/crossref_metadata_2025 huggingface dataset:
AVALIAÇÃO DAS PROPRIEDADES TERMOANÁLITICAS, MICROESTRUTURAIS E MECÂNICAS DOS FILMES PRODUZIDOS POR BASE DE MATRIZ SPI COM INCORPORAÇÃO DE POLISSACARÍDEOS
Authors: Picolloto Angela Maria , Filho Lucidio Molina , Amado Laíz Ravazzi , Bittencourt Paulo Rodrigo Stival , Silva Keila de Souza
Published: February 2025

O presente trabalho teve como objetivo principal estudar, avaliar, e comparar, a estabilidade térmica das interações entre proteína de soja isolada com três polissacarídeos ajustados em pHs extremos 3 e 11. Resultados sugeriram que a interação de matrizes filmógenas SPI + alginato se mostrou mais termoresistente, com Tonset = 67,7. Tanto a DTG como a DSC foram sensíveis para identificação das temperaturas de maior cinética da desnaturação. A DSC explorou as temperaturas de agregação térmica superiores à 113,0 para as soluções na fase pós-desnaturação, com exceção na mistura SPI + pectina. Após a análise dos resultados termoanáliticos das soluções os filmes preparados foram ajustados em pH 11 e tratados nas temperaturas otimizadas características a partir dos resultados da DTG.  Temperaturas de agregação térmica dos filmes foram identificadas nos perfis exotérmicos DSC dos filmes SPI, SPI + pectina, SPI + alginato e SPI + goma alfarroba sugerindo que com o aquecimento pós-desnaturação as ligações covalentes tendem a se formarem. No entanto, devido a pouca variação da entalpia envolvida nestes fenômenos, os resultados sugeriram fragilidade nas ligações químicas após a gelificacão das proteínas e misturas nos filmes. As micrografias obtidas indicam alterações morfológicas com a temperatura de tratamento térmico. Resultados das propriedades mecânicas demonstram atenuação da magnitude das propriedades mecânicas com o aquecimento
ESTUDO DAS PROPRIEDADES MECANICAS DO CONCRETO COM A INCORPORAÇÃO DE BAMBUSOIDEAE
Authors: Santos Gustavo Soares , Souza Gleicielle dos Santos
Published: February 2025

Com a presente tendência ao esgotamento de recursos naturais, a sociedade busca incessantemente meios de minimizar os impactos causados pelo desenvolvimento. Dentre as técnicas mitigadoras destes impactos destacam-se, principalmente, a busca por novas metodologias, processos menos poluentes e mais eficazes além do uso de materiais alternativos. Partindo destas premissas e na busca por alternativas sustentáveis, esta pesquisa estuda a viabilidade da utilização das fibras vegetais, especificamente as fibras de bambu, na confecção de concretos a fim de obter acréscimos positivos na propriedade resistiva à tração do material confeccionado, otimizando o compósito e diminuindo a deficiência do concreto convencional a resistir a tais esforços de tração. Foram realizados os ensaios de compressão axial, com objetivo analítico em referência ao comportamento resistente aos esforços de compressão do concreto confeccionado com as fibras propostas, e o ensaio de tração por compressão diametral, a fim de analisar os acréscimos obtidos a esta propriedade, constatando a eficiência das fibras através da aplicação de porcentagens que variaram entre 0,5 e 8,00% em relação ao consumo de cimento. Expondo os resultados obtidos, constatou-se nesta pesquisa que as propriedades do concreto reforçado por fibras estabelecem melhor equilíbrio entre 0,5 e 1,00% de fibras aplicadas ao concreto.
ANÁLISE E APLICAÇÃO DO MÉTODO DE NEWTON-RAPHSON NA DETERMINAÇÃO DOS PARÂMETROS DO CIRCUITO EQUIVALENTE DE CÉLULAS SOLARES
Authors: Martins Luís Fabiano Barone
Published: February 2025

Neste estudo, foi avaliado o método de Newton-Raphson para a determinação dos parâmetros do circuito equivalente de células solares, particularmente no contexto do modelo de diodo único composto por cinco parâmetros. Um dos desafios enfrentados foi a dificuldade em encontrar valores iniciais próximos o suficiente da solução para garantir a convergência do método de Newton-Raphson. Para superar essa dificuldade, foi apresentado um procedimento para modelagem e simulação de módulos fotovoltaicos comerciais, que foi cuidadosamente validado por meio da comparação com as curvas corrente-tensão (I-V) fornecidas pelos fabricantes. Nesse contexto, a inovação apresentada nesta metodologia envolveu a proposição de novas equações destinadas a calcular as variáveis iniciais necessárias para a aplicação do método de Newton-Raphson. Além disso, foi introduzida uma constante redutora, a fim de mitigar potenciais problemas de convergência, com a intenção de aprimorar a eficiência do método. Essas abordagens combinadas possibilitaram uma análise detalhada da dinâmica de convergência do método de Newton-Raphson, realçando sua notável capacidade de se aproximar de soluções precisas, mesmo quando confrontado com a dificuldade inerente de encontrar valores iniciais adequados. Essa abordagem se mostrou promissora para a determinação de parâmetros do circuito equivalente de células solares, destacando a necessidade de compreender as complexidades e limitações subjacentes aos modelos teóricos.
GERAÇÃO DE ENERGIA ELÉTRICA A PARTIR DE RESÍDUOS SÓLIDOS URBANOS
Authors: Neves Laura , Evaristo Ronaldo Mendes
Published: February 2025

A produção crescente de resíduos sólidos urbanos (RSU) tornou-se um desafio para as administrações públicas, devido ao aumento da população. A implementação efetiva de um sistema de reciclagem enfrenta vários obstáculos, associados ao nível de desenvolvimento, hábitos e situação econômica da população, assim como à disponibilidade de tecnologias e infraestruturas adequadas. O tratamento e a disposição final dos RSU são etapas cruciais de gestão, determinando não apenas o destino desses resíduos, mas também seus impactos. A persistência de lixões em áreas urbanas e sua influência na saúde e no ambiente são preocupações significativas. Quando gerenciados adequadamente, esses resíduos podem ser uma fonte viável de energia elétrica, seja por meio da incineração ou da digestão anaeróbica, por exemplo. Este estudo, realizado como uma revisão integrativa no período de maio a outubro de 2023, selecionou cinco artigos publicados em português entre 2007 e 2016 após critérios de análise. Seu objetivo é esclarecer os problemas na gestão dos RSU no Brasil, as formas de tratamento, disposição final e os métodos de recuperação energética para a geração de eletricidade. A busca por informações foi conduzida no Google Acadêmico, Scielo e sites como o do Ministério do Meio Ambiente. A Política Nacional de Resíduos Sólidos visa promover práticas sustentáveis na produção e disposição final, porém é necessário aumentar os investimentos em pesquisa, infraestrutura e capacitação para aproveitar o potencial energético dos RSU. Em 2022, apenas 6% desses resíduos foram tratados como fonte de energia, enquanto mais de 29 mil toneladas foram destinadas a aterros controlados e lixões.
PROJETO DE UMA BANCADA DIDÁTICA BALL AND BEAM PARA ENSINO DE TÉCNICAS DE CONTROLE
Authors: Lemke André Wille , Evald Paulo Jefferson Dias de Oliveira
Published: February 2025

A implementação de um controlador nem sempre é uma tarefa simples. Embora haja inúmeros livros sobre introdução aos sistemas de controle ou fundamentos de sistemas realimentados, muitas vezes assimilar essa teoria e colocá-la em prática não é tão trivial quanto realizar uma simulação numérica devido às particularidades da implementação em um microcontrolador. Desta forma, implementar tais técnicas de controle em um sistema real durante as aulas é uma forma assertiva de compreender como implementar essas estratégias e reter esse conhecimento de forma efetiva. Entretanto, protótipos que emulam sistemas industriais são caros, o que muitas vezes inviabiliza essas práticas. Portanto, esse artigo apresenta o projeto de uma bancada didática de baixo custo para aprendizado de técnicas de controle. A bancada em questão é um sistema barra-bola (ball and beam), frequentemente utilizada como exemplo nos livros de controle clássico. Os componentes principais dessa bancada são um microcontrolador STM32, que possui um microprocessador ARM Cortex M3 de 32 bits, um motor de passo, um sensor óptico de proximidade, além de uma bola e uma barra composta de material acrílico. Essa bancada permite a implementação de diversas técnicas de controle clássicas e modernas, sendo um recurso para enriquecer o ensino de sistemas de controle em diversas disciplinas das engenharias.
ÁLGEBRA DE HOPF PROVENIENTE DE ESTRUTURAS PARCIAIS
Authors: Martini Grasiela
Published: February 2025

Nos trabalhos de (MAJID, 2000) e (TAKEUCHI, 1981) foi definido o conceito de par combinado envolvendo biálgebras (álgebras de Hopf) e, com isso, foi construído novas estruturas de biálgebras (álgebras de Hopf), sob certas condições adicionais. Seguindo o mesmo intuito de gerar exemplos de álgebras de Hopf, neste trabalho definimos par combinado parcial, envolvendo neste caso, ações e coações parciais, generalizando assim, tanto o trabalho de Takeuchi quanto o de Majid. Por meio desse conceito, além de construir álgebras de Hopf exibimos uma ferramenta que nos proporciona uma família de exemplos.
Burgers' PINNs with implicit Euler Transfer Learning
Authors: Biesek Vitória , Konzen Pedro Henrique de Almeida
Published: February 2025

Burgers’ equation is a well-established test case in mathematical analysis and numerical simulations of convective-diffusive Partial Differential Equations (PDEs). In our study, we focus on the viscous Burgers equation with initial and Dirichlet boundary conditions. In this work, we present an alternative Physics-informed Neural Network with an implicit Euler transfer learning approach to solve the Burgers’ equation. The solution is sought as a sequence of Multilayer Perceptrons (MLPs), one per time step. As an iterative procedure, a first MLP learns the initial condition. Having an MLP that estimates the solution of a given time, its knowledge is transferred to a new MLP that learns the solution at a next time step by training to minimize the residual of the implicit Euler scheme. The methodology is discussed and applied to three classical test cases. In the first, we discuss the determination of the network architecture. We observe the problem of a false stationary state and present a strategy to overcome this issue. The second is a shock wave and the third is a rarefaction problem. The proposed approach allows us to deal with smaller neural network architectures in comparison to the classical PINN approaches. This has the potential to enhance computational performance.
Mapeamento das capacidades de pesquisa sobre a Mata Atlântica no Brasil:
Authors: Caballero Rivero Alejandro , Lazzarotto Freitas Juliana , Santos Raimundo Nonato Macedo dos , Silva Fábio Mascarenhas e
Published: February 2025

Este estudo tem como objetivo geral mapear as capacidades de pesquisa existentes no Brasil sobre a Mata Atlântica. Como objetivos específicos, identificar e caracterizar a produção científica sobre o bioma, bem como os programas de pós-graduação e os grupos de pesquisa envolvidos com pesquisa sobre esse domínio, descrevendo suas áreas de concentração e linhas de pesquisa. Realiza uma análise bibliométrica da produção coletada da base SciELO e da Biblioteca Digital de Teses e Dissertações. A seguir, realiza uma análise cientométrica dos programas de pós-graduação e dos grupos envolvidos com pesquisas sobre esse bioma, a partir dos dados coletados da Plataforma Sucupira e do Diretório dos Grupos de Pesquisa. A produção científica em artigos, teses e dissertações tem crescido de forma substancial a partir da década dos anos 2000. Identifica-se um núcleo consistente de capacidades de pesquisa, conformado por instituições e pesquisadores que se concentram prioritariamente na grande área das Ciências Biológicas e na região Sudeste Brasileira. Observa-se um crescimento expressivo dos programas, áreas de concentração e linhas de pesquisa sobre a Mata Atlântica na pós-graduação brasileira, com capacidades de pesquisa importantes nos temas mais diretamente relacionados com o bioma, tais como Ecologia e Biodiversidade, mas também em outros temas. Adicionalmente, capacidades de pesquisa sobre a Mata Atlântica também foram identificadas nos grupos de pesquisa, concentradas, principalmente, nas Ciências Biológicas (Ecologia, Zoologia, Botânica), mas também nas Ciências Exatas e da Terra (Química, Geociências) e Ciências Agrárias (Agronomia).
Expansão da Pós-Graduação ou concentração da excelência? Desigualdades regionais persistentes no Brasil
Authors: Tischer Wellington , Turnes Valério Alecio
Published: February 2025

Este artigo analisa a descentralização do sistema de educação superior brasileiro com foco na distribuição regional e da excelência dos programas de pós-graduação. Nas últimas duas décadas, as políticas públicas têm focado a expansão de número de programas de pós-graduação, com destaque para as instituições federais de ensino superior. A partir dos dados disponibilizados pelo Sistema de Informação Georreferenciada, observou-se que houve uma desconcentração relativa dos programas de pós-graduação para novos campi no interior que contrasta com as capitais dos estados que aumentaram em termos de densidade e importância em termos de excelência, enquanto programas de pós-graduação em cidades do interior continuam dispersos e fragmentados. A região Sudeste ainda apresenta os melhores indicadores de pesquisa e pós-graduação, especialmente no estado de São Paulo, onde três universidades estaduais apresentam a maior diferenciação no sistema. Os Planos Nacionais de Pós-Graduação (1975-2010) têm focado a redução das desigualdades regionais e incremento de qualidade da pós-graduação. No entanto, o presente trabalho avalia que alguns programas de pós-graduação atingiram um nível alto de excelência em lugares centrais, enquanto as assimetrias permanecem intactas no interior do sistema. Os resultados sugerem que poderá haver ajustes e acomodações nas instituições de ensino superiores públicas e privadas para enfrentar um período de austeridade ainda maior no financiamento público pelo governo federal.
20D-Dynamic Representation of Protein Sequences Combined with K-means Clustering
Authors: Bielińska-Wąż Dorota , Wąż Piotr , Błaczkowska Agata
Published: February 2025

Objective:

The objective of this research is to demonstrate that alignment-free bioinformatics
approaches are effective tools for analyzing the similarity and dissimilarity of protein
sequences. All numerical parameters representing sequences are expressed analytically, ensuring
precision, clarity, and efficient processing, even for large datasets and long sequences. Additionally,
a novel approach for identifying previously unknown virus strains is introduced.

Methods:

A novel approach is proposed, integrating the unique features of our newly developed
method, the 20D-Dynamic Representation of Protein Sequences, with the K-means clustering algorithm.
The sequences are represented as clouds of material points in a 20-dimensional space
(20D-dynamic graphs), with their spatial distribution being unique to each protein sequence. The
numerical parameters, referred to as descriptors in molecular similarity theory, represent quantities
characteristic of dynamic systems and serve as input data for the K-means clustering algorithm.

Results:

Examples of the application of the approach are presented, including projections of the
20D-dynamic graphs onto 3D spaces, which serve as a visual tool for comparing sequences. Additionally,
cluster plots for the analyzed sequences are provided using the proposed method.

Conclusion:

It has been demonstrated that the 20D-Dynamic Representation of Protein Sequences,
combined with the K-means clustering algorithm, successfully classifies subtypes of influenza
A virus strains.
Modeling the Physico-Chemical Characteristics of Benzenes through the Application of Zagreb Rho Indices
Authors: Çiftçi İdris
Published: February 2025

The exploration of Quantitative Structure-Property Relationship (QSPR) frameworks
utilizes topological indices to clarify the chemical and physical attributes of molecular entities.
In the current investigation, we initially identified the rho degree of a vertex in conjunction with
the Zagreb rho indices associated with connected graphs, marking a notable progression within
the field of (chemical) graph theory. We demonstrate that there are correlations exceeding 0.94
between the Zagreb rho indices and the physicochemical properties of benzenes, which encompass
boiling point, pi-electron energy, molecular weight, polarization, molecular volume, and
relative formula mass. Our results reveal that the correlation coefficients between the Zagreb rho
indices and the established degree-based topological indices of benzenes exceed 0.93. Additionally,
we performed structural sensitivity and abruptness analyses of these novel indices and
compared them with alternative topological indices. The results and analyses provide evidence
that Zagreb rho indices are pertinent to QSPR research initiatives.
Innovative Horizons in Drug Design: Exploring the Synthesis and
Medicinal Properties of Heterocyclic Schiff Bases. A Review
Authors: Khan Yousaf , Sarfraz Hina , Rehman Wajid , Khan Momin , Rasheed Liaqat , Rahman Khursheed Ur
Published: February 2025

Schiff bases are an important scaffold for designing drug development. They are characterized
by having a carbon-nitrogen double bond. This double bond is synthesized by different synthetic
schemes by both the aromatic and aliphatic chains. Bases inspired chemists due to their versatile
importance in drug discovery and drug development. A large number of drugs are designed
through the heterocyclic Schiff base moieties. This review highlighted the importance of Schiff bases
concerning their bioactive importance in drug design. Moreover, amide-iminol tautomerism is a
significant tool for the high biological importance of Schiff bases due to the presence of the C=N
bond. Furthermore, the reported synthesized heterocyclic scaffolds Schiff bases have a wide range
of biological importance. Due to this different biological importance, such as antimicrobial, anticonvulsant,
analgesic, antioxidant, antimalarial, anti-inflammatory, anticancer, antidiabetic, and antileishmanial
properties, the researcher has shown their interest by synthesizing different heterocyclic
Schiff bases. In this review article, biologically active heterocyclic Schiff bases were reviewed
intensively concerning drug design and drug development.
Targeted Management: Unlocking the Crucial Role of PROTACs in Cancer Treatment
Authors: Gupta Priyanka , Dutta Sumit , Kumar Prashant , Kaushik Monika , Ashique Sumel , Bhowmick Mithun
Published: February 2025

Targeted Protein Degradation (TPD) offers a solution, eliminating disease-related proteins and overcoming challenges associated with unintended toxicity and lack of precision. PROTACs (Proteolysis Targeting Chimeras) represent an innovative strategy for the specific degradation of tar-get proteins through the UPS (Ubiquitin–Proteasome System). In comparison to conventional protein inhibitor medications, PROTAC offers advantages in terms of efficacy, selectivity, and the ability to overcome drug resistance in cancer treatment, contributing novel perspectives to the field of anti-cancer drug discovery. Proteins play vital roles in an organism’s health, and misfolded contributes to diseases like neurodegenerative disorders and cancer. Cells maintain protein balance through quality control systems, primarily the UPS and autophagy. Protac, a Targeted Protein Degradation (TPD) strategy, utilizes UPS, employing small molecules to induce targeted protein degradation. PROTAC exhibits promise in preclinical studies and clinical trials for diverse cancers. Notable examples in-clude breast cancer, where PROTAC targets CDK4/6 (cyclin-dependent kinase) and Estrogen Recep-tors (ER), prostate cancer, addressing Androgen Receptor (AR) degradation, hematologic malignan-cies, focusing on AURORA-A and CDKs, and NSCLC (Non-Small-Cell Lung Cancer), targeting Estimated Glomerular Filtration Rate (EGFR), and KRAS. Despite their potential, PROTAC faces challenges, including compensatory protein expression in response to targeted therapies. This com-prehensive review explores recent advancements in PROTAC and related technologies, emphasizing the mechanisms and structures of PROTAC and their applications in proteins targeting cancer.
Monitoring based on Risk Assessment Effects on Lung Cancer in Iran
Authors: Keramatinia Aliasghar , Mohseni Maryam , Davoudi-Monfared Esmat , Ghadyani Rezvaneh , Tavirani Mostafa Rezaei , Mozafari Javad Khaje , Masjedi Mohammad Reza , Movafagh Abolfazl
Published: February 2025

Background:

Lung cancer (LC) is considered the leading type of cancer in the world. Similar
to other countries, smoking is known as the main reason for this disease. The present study aims
to assess the critical factors and risk assessment of LC in Iran.

Materials and Method:

Eligible studies were identified in Web of Science, Google Scholar, GLOBOCAN
data base, PubMed, Science Direct, Scopus, ScieLo, and HAL to find the relevant ones published
up to September 2024. Then, the relevant studies were analyzed using the keywords such as
“risk factor or lung cancer” and “lung cancers or lung tumor”. Finally, the supplementary studies
were addressed by the data provided by the Health Department at the Ministry of Health and Medical
Education of the Islamic Republic of Iran.

Results:

Smoking cigarette increases the cases which are at risk as secondhand smokers. The pattern
of smoking in Iran is increasing, especially among women at young ages. There is scattered and
vague information about gas, air pollution, nutrition and obesity, genetics, occupational exposure, and
lifestyle in LC.

Conclusion:

Smoking is regarded as the most vital risk factor for LC. However, other risk factors
exist, which should be considered in this disease. This study seeks to present the promise of prevention,
as well as providing suggestions to healthcare workers.

conclusion:

Although, the most important risk factor for lung cancer is smoking, there are other most risk factors effect that must be considered in lung cancer. It is obvious in this discussion here.
A Biochemical Investigation of the Prevalence of Hypercalcemia and
Thiazide-Related Hypercalcemia in Patients
Authors: Masoodi Shariq Rashid , Bhat Moomin Hussain , Najar Imtiyaz Ahmed , Khan Mosin S. , Bhat Javaid Rasool , Patyar Sazal , Arora Poonam , Kumar Manish
Published: February 2025

Objective:

Hypercalcemia allied with thiazide diuretics is a widely acknowledged
clinical presentation. Hence, the purpose of this investigation was to ascertain the prevalence of
hypercalcemia and hypercalcemia linked to thiazides and to evaluate serum phosphorous, 25-
hydroxyvitamin D, and parathyroid hormone (PTH).

Methods:

This prospective, cross-sectional research study involved all patients, including
outpatients, and was conducted over a 12-month period. Between December 2017 and December
2018, an aggregate of 373 patients were enrolled. All patients with hypercalcemia (albumincorrected
serum calcium > 10.8 mg/dL) had their medical information put on a proforma,
together with the results of any tests (such as parathyroid hormone (PTH), 25-hydroxyvitamin D,
and serum phosphorus).

Results:

Out of 373 subjects, 7 (2%) were hypercalcemic. The mean corrected calcium levels in
the normo-calcemic group were 9.46 ± 0.60 mg/dL (95% CI, 9.4 – 9.5), and that in the hypercalcemic
group were 11.68 ± 0.82 mg/dL (95% CI, 10.9 – 12.4). Of the seven cases of hypercalcemia,
2 patients (28.6%) had thiazide-associated hypercalcemia (TAH) along with primary
hyperparathyroidism (PHPT). Of the remaining 5 hypercalcemia patients, two more had PHPT,
and one (14.3%) had hypervitaminosis D, whereas no cause was mentioned in the remaining 2
patients. Among the 4 PHPT patients, corrected calcium was slightly higher in those with TAH
vs those without TAH, though the difference was statistically insignificant (11.32 ± 0.43 vs 11.14
± 0.39 mg/dL; P > 0.7).

Conclusion:

TAH is the second primary cause of asymptomatic hypercalcemia after PHPT.
Thus, close coordination between the clinicians, pharmacology, pharmacovigilance, and the biochemistry
department may help in identifying these cases.
A Path to the Formation Mechanism of Propolis Nanoparticles, their Cytotoxicity on 3T3 Fibroblasts, Metastatic Murine B16F10 Cells, and their In vivo Irritability in Animals
Authors: González-Masís Jeimmy , Gonzalez-Paz Rodolfo J. , Ureña Yendry Regina Corrales , Guerrero Simón , González-Camacho Sara , Mora-Ugalde Nohelia , Baizán-Rojas Mónica , Loaiza Randall , Vega-Baudrit José Roberto , Cubero-Sesin Jorge M.
Published: February 2025

Background:

Natural products, such as propolis, are an important source of biologically active compounds
with the potential to treat health disorders. Propolis is a well-known waxy resin recognized for its
antimicrobial, immunomodulatory, and cytotoxic effects.

Objective:

In this study, we aimed to clarify the formation mechanism of propolis nanoparticles from the perspective
of their stability and chemical composition. By evaluating the light absorption behaviour of the nanoparticles
formed in different media and quantifying the polyphenols, we show that they are superficially hydrophobic nanoparticles
with the capacity to encapsulate some polar compounds.

Methods:

Biological activity was evaluated by in vitro cell viability performed on NIH/3T3 fibroblasts incubated
with 10, 100, and 1000 μg/mL of propolis nanoparticles for 48 hours.

Results:

The results show that nanoparticles are cytocompatible, with a proliferation effect. In contrast, the results
of the viability of metastatic murine B16F10 cells indicate that a dose with a concentration of 5 μg/mL in the cell
culture media is sufficient to stop the abnormal cell growth, having an antitumor effect. This effect might be related
to the flavonoids present in the propolis nanoparticles. In vivo dermal irritability tests on New Zealand rabbits show
that propolis nanoparticles' aqueous dissolution was non-irritant.

Conclusion:

According to the results obtained from this study, reducing the size of raw propolis down to nanoparticles
and dispersing them in water solvents enhance its positive effects. The superficially hydrophobic propolis
nanoparticles encapsulate active compounds such as polyphenols and flavonoids, which also confirms their ability
to generate selective effects on the cells, depending on their nature.
Oxidative Stress in Cardiovascular Diseases: Mechanisms and Exploring Advanced Therapies
Authors: - Dushyant , - Balram , Singh Gurvirender , Kumar Nitish , Narwal Smita , Dhingra Ashwani K.
Published: February 2025

The recognition of oxidative stress as a factor influencing the development and progression
of cardiovascular diseases (CVDs) is growing. By producing such reactive oxygen species
(ROS) in diverse areas within cells, including mitochondria and Nicotinamide Adenine Dinucleotide
Phosphate Hydrogen (NADPH)-oxidases, they end up causing damage through the
oxidation of lipids, proteins, and DNA. ROS indicates the beginning of inflammatory responses
and endothelial dysfunction, which are necessary to produce obstructions in blood vessels and
decreased blood vessel function. The fact that oxidative stress plays a significant role in CVD
development draws more attention to the need for novel therapies that aim to correct redox imbalances.
Therefore, natural polyphenols and antioxidants like vitamin C or E have shown their
efficacy in lowering levels of ROS and protecting against the damage caused by oxidative stress.
Anyone attempting to cure CVDs should focus on improving the safety and efficacy of antioxidant
treatments and identifying which patients will benefit from them the most. This paper discusses
not only advanced treatments but also the role played by oxidative stress in such CVD as
high blood pressure, hypercholesterolemia, and ischemic heart disease.
Treating Cardiovascular Disorders with Personalized Medicine
Authors: Garg Ishu , Kumar Harish , Verma Madhu , Chauhan Iti , Panwar Vishal
Published: February 2025

The past decade has appreciated personalized medicine as a novel medical approach
that deals with all practices that are tailored to individual patients. Personalized treatment or personalized
cardiology for cardiovascular disorders is an emerging medicine system for related
patients. Personalized cardiology is solely based on genomics and proteomics; molecular diagnostics
and biomarkers of the cardiovascular system link diagnosis with therapy. Bioinformatics
is useful in CVD risk stratification and might improve risk-estimating algorithms. Personalized
cardiology involves 3D printing, pharmacotherapy, surgery, lifestyle modifications, and combinations
thereof. Understanding the pathology of CVD and identifying causative factors at the
individual level can provide opportunities for developing personalized medicine. Since it offers
novel avenues for diagnosing, preventing, and treating CVD, molecular genetics has made a substantial
contribution to the field of molecular cardiology. Nonetheless, there are still a lot of obstacles
to overcome from the standpoints of science and policy. These obstacles can be avoided
using evidence-based procedures, clinical applications, biomarker-based detection techniques,
comprehensive concepts, and understanding. Targeted therapies may be developed as a result of
improved disease classification and a better knowledge of the individual differences in pathology.
Cardiovascular disorders, like hypertension, angina, or ischemic heart, a condition of reduced
blood flow to the heart, coronary artery disease or damaged blood vessels, myocardial infarction
or resisted blood flow to the myocardium, and cardiac arrhythmia or irregular cardiac cycles are
the primary targets for personalized cardiology. The current review discusses various parameters
for personalizing the treatment of cardiovascular disorders.
The Impact of Aquatic Programme Activities on the Quality of Life for People with Disabilities in the Western Cape, South Africa
Authors: Botha Johane , Connelly Hannah Kate , Haydricks Monique Rose , Johannes Malema Makhaya
Published: February 2025

Introduction

Aquatic activities have been shown to enhance an individual's independence in functionality and contribute to an improved overall quality of life. The benefits that aquatic activities offer during rehabilitation or recreation have often been overlooked or underestimated for those with physical disabilities. Engaging in leisure, recreation, and physical activities, specifically water-based activities, can improve a person with disabilities’ body composition, mobility, and overall quality of life.

Aim of the Study

This study aimed to investigate the impact of aquatic program activities on the quality of life of people with disabilities in the Western Cape.

Methods

This study used quantitative research methods that used a cross-sectional design. A total of 39 participants over the age of 18 years who participated in aquatic activities completed the questionnaire on Google Forms. The researchers explained the study details to the participants and clarified any questions before administering the questionnaire. Descriptive statistics were used to report the data for an individual's quality of life.

Results

Results of this study report that individuals engaging in multiple aquatic activities or participating more frequently tended to have higher Quality of Life scores. The current study demonstrated that participation in aquatic activities enhances the individual's feelings of independence about their functionality. Aquatic activities offer numerous benefits that improve the overall well-being of the individual.

Conclusion

The results contribute to the growing understanding of the positive effects of aquatic interventions, advocating for their inclusion in rehabilitation, recreational, and wellness programmes for individuals with disabilities.
Reducing Low Birth Weight through Integrated Learning Groups: A Pregnancy Education House Approach
Authors: Kurniasari Lia , Nugraheni Sri Achadi , Kartasurya Martha Irene , Agushybana Farid
Published: February 2025

Background

Low birth weight remains a significant public health concern, as it increases the risk of morbidity and mortality in newborns. In Indonesia, pregnant women are encouraged to attend health-monitoring classes, though not all can participate.

Objective

This research aimed to develop an intervention model to enhance existing pregnant women’s classes, called “Rumah Dila” (pregnancy education house).

Methods

A quasi-experimental research was conducted with pre- and post-tests involving 60 pregnant women in the intervention group and 60 in the control group. The Rumah Dila program was implemented over six months, from the second to third trimesters. The program's impact was measured by improvements in maternal health behaviors, birth weight, and infant length.

Results

Wilcoxon and paired sample t-tests revealed significant increases in knowledge, attitudes, and practices in both groups (p=0.001). The Cohen's d effect sizes for knowledge, attitudes, and practices were 1.861, 2.341, and 1.853, respectively. Meanwhile, the effect sizes for birth weight (0.511) and infant length (0.593) indicated a substantial impact on maternal behaviors and a moderate impact on delivery outcomes.

Conclusion

This research study demonstrates that well-monitored support from early pregnancy to delivery is essential to reducing the incidence of low birth weight and low birth length.
Design and Development of Magnetically Retrievable Nanohybrid Catalyst for the Green Synthesis of Paracetamol
Authors: Biswas Pranay , Amin Gahul , Ganai Sintu , Mukherjee Puspal , Bose Debasree , Sarkar Rajib
Published: February 2025

Paracetamol is one of the most prescribed drugs, which requires a global production of
over 200,000 tons/year. The production of paracetamol at the industrial level still relies on multistep
methodologies utilizing stoichiometric amounts of oxidizing and reducing agents and corrosive reagents,
which demands a sustainable protocol for the synthesis of paracetamol. In this article, we
aimed to develop a magnetically retrievable nanohybrid catalyst for the synthesis of paracetamol
under mild and green reaction conditions for up to five cycles. Fe3O4 nanoparticles were synthesized
by the reaction between FeCl2 and the ammoniacal solution of p-nitrophenol. Pd(0) particles were
embedded into the nanoparticle so that it could be used as a magnetically retrievable catalyst. This
hybrid catalyst was successfully utilized in the synthesis of paracetamol in a one-pot reaction with
high yield and efficacy within a short time, demonstrating that the nanohybrid catalyst offers advantages
in the synthesis of drug leads for industrial purposes.
Advancing Clinical Chatbot Validation Using AI-Powered Evaluation With a New 3-Bot Evaluation System: Instrument Validation Study
Authors: Choo Seungheon , Yoo Suyoung , Endo Kumiko , Truong Bao , Son Meong Hi
Published: February 2025

Background

The health care sector faces a projected shortfall of 10 million workers by 2030. Artificial intelligence (AI) automation in areas such as patient education and initial therapy screening presents a strategic response to mitigate this shortage and reallocate medical staff to higher-priority tasks. However, current methods of evaluating early-stage health care AI chatbots are highly limited due to safety concerns and the amount of time and effort that goes into evaluating them.

Objective

This study introduces a novel 3-bot method for efficiently testing and validating early-stage AI health care provider chatbots. To extensively test AI provider chatbots without involving real patients or researchers, various AI patient bots and an evaluator bot were developed.

Methods

Provider bots interacted with AI patient bots embodying frustrated, anxious, or depressed personas. An evaluator bot reviewed interaction transcripts based on specific criteria. Human experts then reviewed each interaction transcript, and the evaluator bot’s results were compared to human evaluation results to ensure accuracy.

Results

The patient-education bot’s evaluations by the AI evaluator and the human evaluator were nearly identical, with minimal variance, limiting the opportunity for further analysis. The screening bot’s evaluations also yielded similar results between the AI evaluator and human evaluator. Statistical analysis confirmed the reliability and accuracy of the AI evaluations.

Conclusions

The innovative evaluation method ensures a safe, adaptable, and effective means to test and refine early versions of health care provider chatbots without risking patient safety or investing excessive researcher time and effort. Our patient-education evaluator bots could have benefitted from larger evaluation criteria, as we had extremely similar results from the AI and human evaluators, which could have arisen because of the small number of evaluation criteria. We were limited in the amount of prompting we could input into each bot due to the practical consideration that response time increases with larger and larger prompts. In the future, using techniques such as retrieval augmented generation will allow the system to receive more information and become more specific and accurate in evaluating the chatbots. This evaluation method will allow for rapid testing and validation of health care chatbots to automate basic medical tasks, freeing providers to address more complex tasks.
The Impact Of Communication Apprehension Levels On Objective Structured Clinical Examination Performance Among Medical Students
Authors: Ramli Muhammad Rizaldi , Pamungkasari Eti Poncorini , . Maryani , Budiastuti Veronika Ika
Published: February 2025

Background: By definition, communication apprehension is the discomfort or nervousness felt when interacting or preparing to interact with others. OSCE, on the other hand, evaluates students' clinical skills through various simulated scenarios. Communication apprehension might impact students' clinical abilities assessed in OSCE, given that these skills also rely on effective communication.Aims: This research aims to explore how the level of communication anxiety correlates with students OSCE performance.Methods: This research involved 201 participants from the Faculty of Medicine at UNS. Data was gathered using the PRCA-24 questionnaire to gauge communication apprehension levels, alongside OSCE scores as secondary data. The relationship between these variables was examined using linear regression analysis.Results: At a significance level of α = 0.05, a significant correlation was found between communication apprehension and OSCE scores. This was supported by a p-value of 0.002 and a coefficient of determination (R squared) of 0.048.Conclusion: It was observed that communication apprehension levels had an impact on OSCE scores.
Keragaman Karakteristik Pembungaan dan Hasil Beberapa Hibrida Semangka (Citrullus lanatus Thunb. Matsum. & Nakai) Hasil Persilangan Puncak
Authors: Aswat Amarilla , Dewi Hayati PK , Sutoyo Sutoyo , Gustian Gustian , Hidayat Cecep Taupik , Kuswandi Kuswandi
Published: February 2025

Varietas semangka hibrida memiliki produktivitas dan keseragaman yang tinggi sehingga diminati oleh konsumen. Penelitian ini bertujuan untuk mengevaluasi beberapa hibrida hasil persilangan antara galur inbrida dengan varietas Serif Saga Agrihorti (SSA) sebagai tetua jantan. Percobaan menggunakan rancangan acak kelompok (RAK) dengan tiga ulangan, melibatkan 12 hibrida hasil topcross dan Serif Saga Agrihorti (SSA) sebagai satu varietas pembanding. Semua genotipe ditanam di lapangan dengan mengikuti praktik agronomi semangka yang standar. Karakteristik yang diamati meliputi waktu berbunga jantan dan betina, umur panen, serta diameter dan bobot buah, ketebalan kulit buah, tingkat kemanisan, dan jumlah biji fertil dan biji steril. Data dianalisis menggunakan ANOVA dilanjutkan dengan uji BNT (Beda Nyata Terkecil). Variabilitas genotipik dan fenotipik, heritabilitas dan koefisien korelasi genotipik dan fenotipik  karakter, diestimasi berdasarkan partisi nilai ragam dari ANOVA. Hasil penelitian menunjukkan variabilitas genetik yang luas pada karakter umur berbunga jantan dan betina, serta bobot buah. Nilai duga heritabilitas yang tinggi diperoleh pada karakter umur berbunga jantan dan betina, bobot buah, diameter buah dan jumlah biji fertil. Empat genotipe hibrida yaitu G1, G6, G8, dan G10, menunjukkan bobot buah dan tingkat kemanisan yang lebih tinggi dibandingkan varietas SSA. Berdasarkan heritabilitas yang tinggi pada karakter bobot buah, maka keempat hibrida ini berpotensi untuk dikembangkan menjadi varietas semangka hibrida baru atau dimanfaatkan sebagai populasi dasar untuk perakitan varietas bersari bebas.
Pengaruh Jenis Media Tanam terhadap Pertumbuhan, Hasil dan Kandungan Flavonoid Ciplukan (Physalis peruviana L.)
Authors: Putri Aidha Rusita , Respatie Dyah Weny , Purwantoro Aziz
Published: February 2025

Ciplukan (Physalis peruviana L.) merupakan salah satu tanaman liar yang memiliki banyak senyawa, salah satunya adalah flavonoid yang berguna bagi kesehatan. Hal ini membuat tanaman ciplukan berpotensi untuk dibudidayakan secara komersial. Salah satu faktor yang berpengaruh dalam budidaya ciplukan adalah pemilihan jenis media tanam yang tepat sehingga tanaman ciplukan dapat memberikan hasil yang optimal. Penelitian ini bertujuan untuk mengetahui pengaruh jenis media tanam terhadap pertumbuhan, hasil dan kandungan flavonoid ciplukan. Penelitian ini dilaksanakan pada bulan Januari - Juni 2022 di Kebun Tri Dharma, Fakultas Pertanian, Universitas Gadjah Mada, Banguntapan, Bantul, Yogyakarta. Hasil penelitian menunjukan bahwa penggunaan jenis media tanam menggunakan vinasse dapat meningkatkan pertumbuhan dan kandungan flavonoid ciplukan. Sedangkan penggunaan pupuk kandang sapi, pupuk kandang kambing, dan vinasse memberikan pengaruh sama baiknya terhadap hasil tanaman ciplukan.
Research on Green Supply Chain Performance Evaluation of Manufacturing Enterprises
Authors: Feng Kaitai
Published: February 2025

This study addresses the environmental and resource challenges by constructing a green supply chain performance evaluation index system for a Chinese manufacturing enterprise (Company M). Based on the balanced scorecard theory and relevant literature, the system includes five first-level indicators (financial value, customer service, supply chain process, development and innovation, low-carbon environmental protection) and 21 second-level indicators. The entropy weight method and grey relational analysis are applied to evaluate Company M’s green supply chain performance from 2013 to 2021. Results show that the performance fluctuates but generally improves, indicating potential for further enhancement. Relevant suggestions are proposed to optimize Company M’s green supply chain performance.
Economic Suitability of Electronic Fare Meters for Tricycle Drivers in Cabanatuan City
Authors: Palma Clarisse S. , Perez Mariel P. , Padama Sherwin R. , Catahan John Paul G. , Balaria Felipe E.
Published: February 2025

This descriptive study investigated the economic suitability of electronic fare meters for tricycle drivers in Cabanatuan City, Philippines, using a stratified random sampling technique and a self-made survey questionnaire. The research found that tricycle drivers in Cabanatuan City generally operate under a distance-based fare structure with varying passenger ridership and daily income levels. While most drivers were aware of electronic fare meters, their perceptions regarding potential benefits and concerns were mixed. Some expressed concerns about upfront costs and fare reductions, while others acknowledged the potential for fairer fares, improved passenger trust, and easier fare collection. Overall, the findings suggest that electronic fare meters could offer economic benefits for tricycle drivers in Cabanatuan City, particularly through increased efficiency and potentially higher income. However, successful implementation requires careful consideration of driver concerns and the development of strategies to address issues like affordability and potential income fluctuations.
Cashless Transactions: Issues and Challenges in India
Authors: Singh Satvir , Choudhary Minakshi
Published: February 2025

In an attempt to curb-out black money, money laundering, and to have a sound economy, the central government of India has embarked on the cashless economy. It is the birth of a new era in the nation with life with digital money. This paper is going to conceptualize the meaning of a cashless system, explains online banking techniques in India, schemes by government to spread the cashless system in India and highlights the challenges of the cashless economy and electronic payment systems. The objective of this study is to examine the significant challenges that are faced by Indians on the way towards cashless. To achieve the objectives of this exploratory type of personal study, interviews will be conducted.
XKFHnet: Xception Kronecker Forward Fractional Net for Intrusion Detection in Cloud
Authors: Lodha D. R. , P.P. Dr Rokade
Published: February 2025

In this new era of on-demand cloud computing, security is crucial. To find breaches in the cloud computing environment, researchers have surveyed a number of intrusion detection methods. The majority of them discuss conventional abuse and anomaly detection methods. By positioning the analysing component outside the virtual machine, usually at the hypervisor, Virtual Machine Introspection techniques are highly useful in identifying various stealth attacks that target user-level and kernel-level processes operating in VMs. Techniques such as Hypervisor Introspection protect the hypervisor and stop a compromised hypervisor from attacking virtual machines that run on it. Through the use of hardware-assisted used in virtualization-enabled technologies, introspection approaches examine the hypervisor. Our paper's primary goal is to present a thorough literature review of the many intrusion detection methods that have been suggested for cloud environments, along with an evaluation of their capacity to detect attacks. To clarify the vulnerabilities in the cloud, we offer a threat model and attack taxonomy. Our taxonomy of IDS techniques offers a thorough analysis of approaches together with their distinguishing characteristics, and it represents the state of the art in classification. In the survey, we have given a thorough understanding of methods based on Virtual Machine Introspection and Hypervisor Introspection. With the help of our study, researchers should be able to start investigating intrusion detection techniques in cloud environments.
Srimad Bhagavad Gita: The Most Influential And Unique Psycho-Spiritual Didactic Literature on Earth
Authors: Bhattacharjee Purushattom
Published: February 2025

The Srimad Bhagavad Gita, one of the cornerstones of Indian philosophy, stands unparalleled as a psycho-spiritual and didactic masterpiece that has influenced millions over centuries. This divine dialogue between Lord Krishna and Arjuna transcends cultural, religious, and geographical boundaries, offering profound insights into human psychology, spirituality, ethics, and the art of living. This article explores the multifaceted dimensions of the Bhagavad Gita, illustrating how it addresses psychological dilemmas, provides spiritual solace, and imparts timeless lessons for a purposeful life. Real-life examples, scientific validations, and literary influences are cited to substantiate its transformative power. Verses from the Gita are cited to substantiate its didactic and transformative essence.