bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Harga Iuran dan Sanksi terhadap Lama Keterlambatan Pembayaran Iuran Program Jaminan Kesehatan Nasional
Authors: Ariska Rinda Minanti , Nuria Shinta , Budiarto Wasis
Published: August 2024

Latar Belakang: Peserta Jaminan Kesehatan Nasional atau JKN di Indonesia mencapai 252.235.864 dengan cakupan 93,05%. Jawa Timur menjadi salah satu provinsi yang belum mencapai Cakupan Kesehatan Universal dengan cakupan kepesertaan yakni sebesar 88,6%. Untuk Jawa Timur Kota/Kabupaten didalamnya yang telah mencapai Cakupan Kesehatan Universal berjumlah 8 dengan jumlah peserta tidak aktif paling banyak berada di Kota Surabaya yakni sebanyak 591.273 atau 67,5%.
Tujuan: Tujuan dalam penelitian ini untuk mengetahui pengaruh harga iuran dan sanksi terhadap lama keterlambatan pembayaran iuran.
Metode: Jenis penelitian yang dipakai ialah penelitian deskriptif dengan desain cross-sectional, dan sampel penelitian ialah sebanyak 107 peserta program JKN dari kelompok bukan Penerima Bantuan Iuran (Non-PBI) dan pernah atau sedang mempunyai tunggakan iuran JKN di tahun 2022 di Kota Surabaya.
Hasil: Hasil penelitian menunjukan bahwa variabel harga iuran JKN berpengaruh secara signifikan dengan lama katerlambatan (α < 0,05) dengan odds ratio sebesar 0,39 dan CI 95% (-1,892 s/d -0,010). Variabel bentuk sanksi juga berpengaruh signifikan terhadap lama keterlambatan pembayaran iuran JKN (α < 0,05) dengan odds ratio sebesar 0,32 dan CI 95% (-2,068 s/d -0,201).
Kesimpulan: Terdapat pengaruh yang signifikan antara harga iuran JKN dan sanksi terhadap lama keterlambatan pada pembayaran iuran JKN, diharapkan peserta JKN dari kelompok non-PBI dapat mengakses layanan JKN untu mengetahui regulasi JKN dan dapat membayar iuran tepat waktu agar status kepesertaan tetap aktif.
Literature Review: Hubungan Tingkat Pengetahuan, Motivasi dan Sikap terhadap Tindakan Tidak Aman (Unsafe Action) pada Tenaga Kerja
Authors: Putri Marisa Adilla , Fatah Mohammad Zainal
Published: August 2024

Latar Belakang: Tahun 2011 National Safety Council (NSC) menyatakan 88% kecelakaan kerja diakibatkan tindakan tidak aman (unsafe Behavior). Tindakan tidak aman (unsafe action) yaitu tindakan berisiko yang diterapkan para pekerja dengan berbagai sebab yang melatarbelakanginya. Faktor perilaku memiliki peranan yang sangat penting terhadap kejadian kecelakaan kerja.
Tujuan: Tujuan dari penelitian adalah mengetahui hubungan antara pengetahuan, motivasi, dan sikap terhadap tindakan tidak aman pada tenaga kerja.
Metode: Penelitian ini menggunakan metode telaah artikel ilmiah dengan kata kunci pengetahuan, motivasi, sikap, dan perilaku aman pada database google scholar dan PubMed.
Hasil: Hasil dari telaah artikel ilmiah memakai database google scholar dan PubMed menunjukkan terdapat 6 (enam) artikel yang selaras pada kriteria ekslusi dan inklusi, dengan kisaran tahun terbit antara 2018-2023. Artikel yang ditelaah menggunakan bahasa Indonesia dengan jenis penelitian kuantitatif yang menggunakan analisis uji bivariat chi-square.
Kesimpulan: Berdasarkan 6 kajian artikel yang digunakan, peneeliti menemukan terdapat hubungan antara pengetahuan, motivasi, serta sikap terhadap tindakan tidak aman pada tenaga kerja.
Hubungan Kegemukan dengan Prestasi Akademik pada Remaja: Literature Review
Authors: Paramudhita Fiska Azzahra
Published: August 2024

Latar Belakang: Remaja di usia pertumbuhan membutuhkan asupan zat gizi yang lebih besar, karena ketidakseimbangan antara asupan zat gizi dengan kecukupan zat gizi yang dianjurkan akan menjadi salah satu penyebab dari permasalahan gizi yang terjadi pada remaja. Obesitas, kekurangan energi kronis dan anemia merupakan permasalahan gizi yang paling sering terjadi pada remaja di Indonesia. Prestasi akademik menjadi indikator utama untuk mengetahui kemampuan siswa, serta menjadi salah satu penentu kualitas dan tujuan utama dari pendidikan. Terdapat sejumlah faktor yang mempengaruhi prestasi akademik pada remaja, yaitu kesehatan fisik, psikologis (yang sehat, motivasi kestabilan psikoemosional, lingkungan sekolah, kelas keluarga. Salah satu unsur yang memiliki peranan penting dalam mempengaruhi kualitas sumber daya manusia, yaitu kesehatan dan gizi. Dengan demikian, gizi dan status gizi yang terpenuhi menghasilkan sumber daya manusia berkualitas.
Tujuan: Literature review bertujuan untuk menganalisis hubungan antara kegemukan dengan prestasi akademik pada remaja.
Metode: Penelitian ini dilakukan dengan desain literature review yang diperoleh dari artikel jurnal nasional dan internasional dengan isi sesuai topik yang dibahas, berupa original article, full text, open access dan dipublikasikan dalam rentang 10 tahun terakhir, serta proses penelusuran artikel jurnal melalui Google Scholar, Science Direct, Elsevier dan PubMed.
Hasil: Berdasarkan 10 artikel jurnal yang ditemukan sebagian besar artikel jurnal menyatakan bahwa terdapat korelasi pada kegemukan dengan prestasi akademik pada remaja.  Remaja berstatus gizi yang baik akan menerima materi dan berpikir yang baik, serta memperoleh prestasi akademik yang baik pula, karena kecerdasan dan kemampuan dalam menangkap materi dapat dipengaruhi oleh status gizi seseorang. Namun, terdapat sejumlah faktor lainnya yang mempengaruhi prestasi akademik pada remaja, selain status gizi.
Kesimpulan: Berdasarkan analisis yang dilakukan, diperoleh kesimpulan bahwa terdapat hubungan antara kegemukan dengan prestasi akademik pada remaja. Selain itu, kegemukan menjadi salah satu faktor pengaruh prestasi akademik.
Literature Review: Strategi Penurunan Asupan Natrium Melalui Pengurangan Garam untuk Mencegah Hipertensi
Authors: Prasodjo Regita Adjeng , Farapti Farapti
Published: August 2024

Latar Belakang: Prevalensi hipertensi mengalami peningkatan secara global dari tahun ke tahun. Faktor resiko utama terjadinya hipertensi adalah gaya hidup dan pola makan tinggi natrium. Natrium dalam pangan banyak bersumber dari garam. Garam merupakan salah satu bahan yang biasa ditambahkan dalam makanan untuk meningkatkan rasa makanan. Dalam 1 gram garam mengandung 40% natrium dan 60% klorida. Pembatasan natrium melalui pengurangan garam perlu diterapkan untuk mencegah terjadinya hipertensi.
Tujuan: Literatur review ini bertujuan untuk mengetahui strategi-strategi yang diterapkan di berbagai negara untuk mengurangi rata-rata asupan natrium harian melalui pengurangan garam.
Metode: Pencarian artikel menggunakan database PubMed dan ScienceDirect dengan hasil skrinning artikel yang sesuai dengan kriteria ditemukan 5 artikel. Setelah artikel tersebut didapatkan, dilakukan penilaian artikel hingga mencapai tahap pembuatan literatur review
Hasil: Terdapat 5 artikel yang membahas mengenai strategi penerapan pembatasan natrium harian melalui pengurangan garam yang telah diterapkan di berbagai negara.  Strategi-strategi tersebut antara lain pendidikan gizi pada masyarakat, pemajakan garam, pelabelan, dan logo kandungan garam tinggi pada kemasan, dan reformulasi pangan.
Kesimpulan: Berbagai strategi di beberapa negara tergolong efektif untuk membatasi natrium harian melalui pengurangan garam. Pendidikan gizi pada masyarakat efektif untuk menambah pengetahuan dan pemahaman yang mendorong perubahan perilaku pengurangan konsumsi garam, pemajakan garam memberikan efek pada penurunan tingkat penjualan produk pangan kemasan tinggi garam oleh konsumen, pelabelan, dan logo kandungan garam tinggi pada kemasan membantu konsumen membuat pilihan konsumsi pangan rendah garam, dan reformulasi pangan digunakan sebagai cara untuk meningkatkan kemudahan akses pangan rendah garam.
Analisis Evaluasi Sensorik pada Formulasi Produk Sosis dengan Substitusi Bahan Pengganti Kulit Ayam: Literature Review
Authors: Afifah Lyna Nur , Adi Annis Catur
Published: August 2024

Latar Belakang: Sosis ayam merupakan salah satu produk daging yang paling banyak diproduksi dengan biaya produksi yang rendah, menggunakan teknologi yang sederhana dan peralatan yang minim. Cukup banyak penelitian yang mengembangkan produk sosis ayam dengan substitusi bahan kulit ayam dengan bahan lain seperti serat pangan dan produk sampingan dari pemotongan ayam lainnya.
Tujuan: Menganalisis kualitas sosis ayam dari sisi sensorik produk yang mengalami subsitusi bahan baku kulit ayam dengan bahan lain berdasarkan penelitian formulasi yang sudah ada.
Metode: Penelitian ini menggunakan metode penelusuran kepustakaan atau literature review dan berasal dari beberapa sumber database jurnal, yaitu Google Scholar, PubMed, Science Direct dengan kriteria artikel yang membahas tentang pengembangan produk makanan sosis ayam dengan bahan kulit ayam.
Hasil: Berdasarkan hasil pencarian pustaka didapatkan hasil 4 penelitian yang meneliti analisis sensorik dari produk sosis ayam setelah bahan baku kulit ayam disubstitusi dengan bahan lain.
Kesimpulan: Perbedaan hasil analisis sensori pada keempat penelitian tersebut dipengaruhi oleh bahan yang digunakan untuk men-substitusi kulit ayam. Selain itu perbedaan pemilihan dan penilaian dari panelis dipengaruhi oleh persepsi setiap individu terhadap produk yang diberikan perlakuan.
Systematic Review: Tobacco Control and Coronary Artery Disease
Authors: Santoso Audia Fijratullah , Farida Bunga , Ninda Gina Fitri , Hibatullah Faiz Nur , Sari Nur Mufida Wulan , Saleem Haitam Thaleb , Martini Santi , Mahmudiono Trias
Published: August 2024

Backgrounds: The prevalence of cigarette consumption in Indonesia has reached a level that is cause for concern. Currently, more than one-third (36.3%) of Indonesia's population is classified as smokers. The World Health Organization (WHO) ranks Indonesia as the third-largest cigarette market in the world, after China and India. In fact, the prevalence of adult male smoking in Indonesia is the highest (68.8%) in the world, so tobacco consumption has many negative impacts on health, one of which is the main cause of non-communicable diseases (NCDs), such as coronary artery disease (CAD). Tobacco control is one of the efforts that can be made to prevent non-communicable diseases, namely coronary heart disease. Coronary artery disease is a pathological condition that arises due to the accumulation of atheroma in the blood vessels that supply blood to the heart, causing narrowing of the coronary arteries.
Objectives: The aim of this study is to identifying tobacco as the main cause of non-communicable diseases such as coronary artery disease and tobacco control policies
Methods: The method of this study is a literature review using PRISMA as a guide. Articles obtained from databases such as PubMed and Google Scholar with specific relevant keywords “tobacco AND coronary artery disease”, “tobacco AND Non-communicable disease”, “tobacco control”, and “tobacco policy”. Article restricted to only original study within 2019 until 2023.
Results: Tobacco control and prevention efforts that can be carried out regarding NCDs according to the 30 articles are controlling media by a massive pictorial warning; prohibition advertising, promotion, and sponsorship; controlling the price of tobacco by increasing the excise, tax, and selling price; restriction on smoking area, and smoking cessation therapy in a health facility that covered by insurance. Nicotine replacement therapy could be the choice for smoking cessation in CAD patients.
Conclusions: Since limited research on smoking cessation therapy, especially in patients with CAD, it is necessary to develop various therapeutic methods that are easier, affordable, and safe.
Kajian Literatur: Gambaran Implementasi Rekam Medis Elektronik di Rumah Sakit Indonesia berdasarkan Permenkes Nomor 24 Tahun 2022 tentang Rekam Medis
Authors: Izza Ania Al , Lailiyah Syifa'ul
Published: August 2024

Latar belakang: Pada mulanya, seluruh dokumen rekam medis di Rumah Sakit dikelola secara konvensional (manual/tertulis). Namun, seiring berkembangnya kemajuan teknologi informasi dan komunikasi serta didukung adanya kebijakan baru tentang Rekam Medis yang tertuang dalam Peraturan Menteri Kesehatan Republik Indonesia Nomor 24 Tahun 2022 Tentang Rekam Medis dan himbauan langsung dari Kementerian Kesehatan Republik Indonesia, kini rekam medis mulai beralih dari yang semula konvensional menjadi berbasis elektronik.
Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran implementasi Rekam Medis Elektronik (RME) di rumah sakit Indonesia.
Metode: Penelitian ini menggunakan studi kajian literatur dengan penelusuran artikel menggunakan metode Preferred Reporting Items for Systematic Review & Meta-Analyses (PRISMA). Artikel yang digunakan merupakan artikel nasional dengan pencarian melalui google scholar menggunakan kata kunci Bahasa Indonesia, yaitu tantangan dan implementasi RME di rumah sakit; tantangan atau hambatan RME di rumah sakit Indonesia. Kata kunci dalam Bahasa Inggris, yaitu challenges OR barriers to medical record in Indonesian Hospitals; challenges AND implementation of medical record in Indonesian Hospitals. Kriteria inklusi yaitu artikel dengan topik tantangan/hambatan/kendala implementasi rekam medis elektronik di rumah sakit Indonesia, berupa penelitian kuantitatif atau kualitatif maupun kombinasi keduanya, berbahasa Indonesia atau Bahasa Inggris yang dipublikasikan antara 2016-2023. Adapun kriteria eksklusi yaitu artikel dalam bentuk systematic review, literature review atau pengabdian masyarakat.
Hasil: Tantangan, kendala, maupun hambatan yang dialami oleh rumah sakit Indonesia dalam menyelenggarakan rekam medis elektronik seperti terkait dengan Sumber Daya Manusia (SDM), sarana dan prasarana, kelompok resisten, koneksi jaringan, belum tersedia Standar Operasional Prosedur (SOP) tetap, sistem yang terkadang eror, finansial, serta keamanan komputer dan sistem.
Kesimpulan: Implementasi Rekam Medis Elektronik (RME) di rumah sakit Indonesia jika dilihat berdasarkan 19 artikel yang telah dilakukan analisis menunjukkan adanya ketidaksiapan rumah sakit dalam menyelenggarakan RME. Hal tersebut ditunjang dengan adanya tantangan, kendala, maupun hambatan yang dialami selama proses penerapan Rekam Medis Elektronik (RME). Pemerintah sebaiknya meninjau langsung perihal tantangan, kendala, maupun hambatan yang terjadi sehingga kebijakan yang dikeluarkan dapat dijalankan dengan baik oleh seluruh rumah sakit di Indonesia.
Hubungan Pengetahuan dan Sikap dengan Konsumsi Sugar-Sweetened Beverages pada Wanita Usia Produktif
Authors: Setyanurlia Anggita Rifky , Sumarmi Sri
Published: August 2024

Latar Belakang: Konsumsi minuman manis atau Sugar-Sweetened Beverages (SSB) merupakan kebiasaan yang umum dilakukan masyarakat dengan anggapan bahwa minuman SSB sebagai minuman masyarakat atau social drink. Tingkat konsumsi SSB pada wanita usia produktif dapat dipengaruhi oleh tingkat pengetahuan dan sikap dalam mengonsumsi SSB. Apabila pengetahuan dan sikap positif terhadap konsumsi SBB dan kesehatan maka seseorang akan mencermati kualitas dan kuantitas makan dan minuman yang dikonsumsi. Kontrol glikemik diperlukan dalam mengontrol kadar glukosa darah berdasarkan diet yang meliputi jenis dan jumlah makanan dan minuman yang dikonsumsi.
Tujuan: Penelitian ini bertujuan untuk menganalisa hubungan pengetahuan dan sikap dengan konsumsi Sugar-Sweetened Beverages (SSB) pada wanita usia produktif di Kota Surabaya.
Metode: Penelitian ini merupakan jenis penelitian deskriptif kuantitatif dengan design penelitian cross sectional. Sampel penelitian terdiri dari 125 responden wanita usia produktif berusia 18-30 tahun yang diambil dengan teknik pengambilan sampel bebas (accidental sampling). Pengumpulan data terdiri dari karakteristik responden yaitu umur, pendidikan, pendidikan, kuesioner pengetahuan responden terkait konsumsi SSB, kuesioner sikap dalam konsumsi SSB, dan SQ-FFQ (Semi Quantitative-Food Frequency Questionnare). Data yang dikumpulkan dianalisis dengan analisis statistik uji Chi-Square untuk menguji hubungan antara variabel independent dan variabel dependent dengan signifikansi kepercayaan 95% (α=0,05).
Hasil: Hasil penelitian menunjukkan bahwa tidak terdapat hubungan yang bermakna antara pengetahuan (p=0,504) dan sikap (p=0,332) dengan konsumsi Sugar-Sweetened Beverages (SSB).
Kesimpulan: Responden wanita usia produktif memiliki pengetahuan baik, sikap positif terhadap konsumsi Sugar-Sweetened Beverages (SSB), mengonsumsi SSB dalam jumlah yang rendah (<2x per minggu), rata-rata konsumsi energi total/hari dan rata-rata konsumsi gula/hari dari konsumsi SSB telah sesuai dengan rekomendasi. Namun, beberapa responden dengan pengetahuan dan sikap positif masih mengonsumsi SSB dalam jumlah tinggi. Pengetahuan dan sikap belum tentu menjadi faktor utama yang memberikan pengaruh terhadap konsumsi SSB. Faktor determinan pemilihan makanan dan minuman dapat diteliti lebih lanjut untuk mengetahui faktor-faktor pendukung konsumsi SSB.
Analisis Time Series ARIMA untuk Memprediksi Jumlah Peserta KB Baru Pasca Persalinan di Jawa Timur
Authors: Diningestu Rohyatul Fadhila , Mahmudah Mahmudah
Published: August 2024

Latar Belakang: Metode peramalan yang masih digunakan saat ini adalah time series. Analisis time series digunakan untuk menganalisis data dengan mempertimbangkan faktor waktu. ARIMA (Autoregressive Integrated Moving Average) merupakan model time series yang tidak mengharuskan adanya pola tertentu dalam data. Jumlah peserta KB (Keluarga Berencana) baru pasca persalinan di Jawa Timur mengalami penigkatan dan penurunan.
Tujuan: Penelitian ini untuk memprediksi jumlah peserta KB baru pasca persalinan di Jawa Timur.
Metode: Penelitian ini menggunakan metode penelitian non-reaktif. Data sekunder yang digunakan merupakan jumlah peserta KB baru pasca persalinan di Jawa Timur pada bulan Januari 2017 hingga Desember 2021. Data ini diperoleh dari website BKKBN.
Hasil: Dalam penelitian ini, metode ARIMA menghasilkan model terbaik yaitu ARIMA (1,1,1) dengan nilai parameter AR (1) sebesar 0,413, nilai parameter MA (1) sebesar 0,914. Nilai MSE (Mean Square Error) yang di hasilkan sebesar 935.384, nilai MAPE (Mean Absolute Persentage Error) sebesar 4.671.
Kesimpulan: Hasil prediksi jumlah peserta KB baru pasca persalinan di Jawa Timur pada tahun 2022 mengalami peningkatan setiap bulannya. Pada bulan Januari dengan 14.523 peserta, dan pada bulan Desember meningkat dengan jumlah 15.127 peserta. Program KB tetap dijalankan untuk tetap meningkatkan pengguna KB pasca persalinan dimasa yang akan datang.
Flow cytometry for extracellular vesicle characterization in COVID-19 and post-acute sequelae of SARS-CoV-2 infection
Authors: Fanelli Marialaura , Petrone Vita , Chirico Rossella , Radu Claudia Maria , Minutolo Antonella , Matteucci Claudia
Published: August 2024

Infection with SARS-CoV-2, the virus responsible for COVID-19 diseases, can impact different tissues and induce significant cellular alterations. The production of extracellular vesicles (EVs), which are physiologically involved in cell communication, is also altered during COVID-19, along with the dysfunction of cytoplasmic organelles. Since circulating EVs reflect the state of their cells of origin, they represent valuable tools for monitoring pathological conditions. Despite challenges in detecting EVs due to their size and specific cellular compartment origin using different methodologies, flow cytometry has proven to be an effective method for assessing the role of EVs in COVID-19. This review summarizes the involvement of plasmatic EVs in COVID-19 patients and individuals with Long COVID (LC) affected by post-acute sequelae of SARS-CoV-2 infection (PASC), highlighting their dual role in exerting both pro- and antiviral effects. We also emphasize how flow cytometry, with its multiparametric approach, can be employed to characterize circulating EVs, particularly in infectious diseases such as COVID-19, and suggest their potential role in chronic impairments during post-infection.
Narrative Cycles: What Drove Postwar Stock Market Dynamic?
Authors: Milovidov V.
Published: August 2024

The United States is considered the world’s leading center of economic power, which, in particular, is determined by the role played by the U.S. stock market in the world economy. Largely due to the capacity of this market, the U.S. dollar plays the role of the dominant world currency. The state of the U.S. financial market is important for global financial stability. This determines the importance of finding the factors that determine the dynamics of the U.S. stock market. In this article, the author offers his chronology of post-war financial cycles in the United States and analyses them in light of the changing social narratives that accompanied these cycles. Reviewing the literature on financial cyclicality and financial bubbles, the author argues that the efficient market hypothesis can be enriched by research from behavioral finance. As the author suggests, stock prices may reflect not only economic and financial information, but also a broader set of information signals. The author proposes to consider narratives as such information signals that can be used by investors in the decision-making process. In conditions of mass influx of retail investors into the market, the importance of narratives as information signals increases and their connection with market dynamics becomes even clearer. The author sets the boundaries of three long-term periods of market development (1949–1974, 1974–2003, 2003–2021) and then analyses these periods to identify distinct phases of market growth and decline. In order to identify such phases, the author uses a simple rule of decreasing minima: in the case of a general growth trend of the stock index, interrupted by its short-term falls (corrections), its minimum value after each correction is greater than the minimum value of the previous correction. The moment when the index falls below the previous minimum value can be considered as the end of the upward phase of the market. According to the chronology of financial cycles proposed by the author, in the entire post-war period there is an alternation of long-term and shortterm periods of growth of stock market quotations. By analyzing their variability, the author concludes that there are relatively stable market patterns that can be repeated in the future. At the same time, the author notes that the influence of non-economic events, in particular geopolitical conflicts and crises, sudden shocks such as a pandemic, weakens the predictive nature of historical cyclicality. In the author’s opinion, under these conditions, the importance of analyzing narratives as information signals increases significantly, as they usually reflect all the key events and phenomena that attract people’s attention.
The Impact of Celebrity News on Entertainment Industry Stock Prices
Authors: Widuri Alexandra , Husodo Zaäfri Ananto
Published: August 2024

South Korea’s entertainment industry has gained global popularity. However, the competition between entertainment companies is intense, requiring strategies to ensure their survival, such as imposing restrictions on their artists to maintain their public image and trust. This study examined the impacts of celebrity news and activities on the stock returns of six major entertainment companies listed on the Korea Exchange (KRX) from 2018 to 2021. Using the Fama/French 3 Factors Model regression, the study investigated the presence of abnormal returns. The findings indicate that comebacks and debuts elicit positive reactions and generate significant abnormal returns. Award acceptances and military service also elicit positive reactions but do not generate significant abnormal returns. Conversely, dating news, internal scandals, and national scandals elicit negative reactions, with only national scandals generating significant abnormal returns. These results imply that entertainment companies and investors should actively manage and monitor celebrity news to make informed decisions.
The Impact of Environmental, Social and Governance (ESG) Practices on the Financial Performance of Green Companies in Malaysia: An Empirical Analysis
Authors: Zainuddin Zaemah , Wahab Norazlina Abd. , Shari Wahidah , Bahaman Muhamad Abrar , Yusof Rosylin Mohd
Published: August 2024

This study examines the relationship between Environmental, Social, and Governance (ESG) performance and the financial performance of green companies in Malaysia. Analyzing 280 observations from 56 green companies listed in Bursa Malaysia from 2016 to 2020, the study employs rigorous regression analysis. The results indicate that ESG performance does not significantly influence the financial performance of these green companies. Instead, total sales and liability significantly impact both Return on Asset (ROA) and Return on Equity (ROE). These findings suggest that, despite the growing emphasis on ESG in the business sphere, other internal factors may have a more substantial effect on financial outcomes. While ESG considerations may not directly financial performance, their importance for social welfare and sustainable resource management remains indisputable.
Determinants of Islamic Banks’ Stability in Malaysia and Indonesia
Authors: Saddam Siti Zaitun  , Jaafar Mohamad Nizam , Muhamat Amirul Afif , Nizam Nurien Syahirah Mohd , Halim Nurin Aqilah
Published: August 2024

The economic prosperity of any nation relies on its banking sector, which serves as the linchpin of the economy. This paper investigates key bank specific factors influencing the stability of Islamic banks in Malaysia and Indonesia from 2012 to 2021. Using panel data analysis, the study identifies the fixed effect model as the optimal approach. The subsequent fixed effect regression analysis highlights the significance of the cost-to-income ratio in determining financial stability for both Malaysian and Indonesian Islamic banks. Notably the study reveals that the non-performing loan ratio is the primary stability indicator in Malaysia, while Indonesian counterparts prioritize maintaining a robust capital adequacy ratio. The study recommends vigilant regulatory oversight of capital adequacy and prudent expense management to safeguard banks against instability, fostering sustained financial health and success.
Dependable Automated Approach for Measuring the Retrograde Superior Ramus Screw Corridor in Pelvic Fracture Fixation
Authors: Zhao Jing-Xin , Chen Hua , Dong Mingjie , Ju Fujiao , Lyu Houchen , Zhang Li-Cheng , Tang Pei-Fu
Published: August 2024

Background:

Precise measurement of the intraosseous corridor within the superior pubic ramus is essential for the accurate percutaneous placement of a retrograde superior ramus screw (SRS). However, conventional manual measurement methods are often subjective, leading to variations in results among observers. Our goal was to develop an automated and dependable method for determining the retrograde SRS corridor.

Methods:

We developed an automated technique that utilized a computed tomography (CT) image-based search algorithm to identify the retrograde SRS corridor with the maximum diameter. We evaluated the reliability of this automated approach in comparison to a manual method using 17 pelves. Subsequently, we used both methods to measure the diameter, length, and orientation of the retrograde SRS corridor in 204 pelves in a Chinese population and assessed the intra- and interobserver agreement of each method by calculating the root-mean-square error (RMSE) and constructing Bland-Altman plots. We determined the screw applicability (percentages of hemipelves that could be treated with specific sizes of screws) for each method. Additionally, we investigated potential factors influencing the corridor, such as sex, age, height, and weight, through regression analysis.

Results:

The intra- and interobserver intraclass correlation coefficients (ICCs) for the automated method (0.998 and 0.995) were higher than those for the manual approach (0.925 and 0.918) in the assessment of the corridor diameter. Furthermore, the diameter identified by the automated method was notably larger than the diameter measured with the manual method, with a mean difference and RMSE of 0.9 mm and 1.1 mm, respectively. The automated method revealed a significantly smaller corridor diameter in females than in males (an average of 7.5 and 10.4 mm, respectively). Moreover, use of the automated method allowed 80.6% of the females to be managed with a 4.5-mm screw while a 6.5-mm screw could be utilized in 19.4%, surpassing the capabilities of the manual method. Female sex had the most substantial impact on corridor diameter (β = −0.583).

Conclusions:

The automated method exhibited better reliability than the manual method in measuring the retrograde SRS corridor, and showed a larger corridor diameter for screw placement. Females had a significantly smaller corridor diameter than males. Given the intricate nature of the automated approach, which entails utilizing different software and interactive procedures, our current method is not readily applicable for traumatologists. We are working on developing integrated software with the goal of providing a more user-friendly solution for traumatologists in the near future.

Level of Evidence:

Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Origin and evolution of groundwater in the Goharzamin mine area using hydro-geochemical and isotopic analyses
Authors: Saberinasr Amir , Kalantari Nasrollah , Ghelichpour Hassan , Morsali Massoud
Published: August 2024

Determining the source of groundwater infiltrating mine pits is one of the most interesting challenge for mining engineers and designers. The uncontrolled groundwater flow will delay the planned schedule and have a negative impact on extraction costs and mining operations. Determining the groundwater source by hydrochemical and isotopical interpretations in the Goharzamin iron mine, located in south-central Iran, plays a significant role in comprehending hydrochemical and hydrogeological processes and designing an effective dewatering system in this mining area. Through three phases of groundwater sample collection from seepages and boreholes, a total of 75 samples were gathered for analysis, including 12 samples containing heavy metals and stable isotopic data (D and 18O), 5 samples containing 14C and 13C, and another 5 samples containing 3H data. Results indicated that all samples belonged to saline and brackish water categories (EC > 4 mS cm− 1), with a predominant sequence of Cl−-SO42−-HCO3−-NO3−, and Na+-Ca2+-Mg2+-K+ for anions and cations, respectively. Conservative tracers (Cl, Br, and B) and stable isotopes demonstrated that Kheirabad Salt Lake (located approximately 13 km north of the mine) is unlikely to be the source of groundwater. Radiocarbon and tritium age dating suggested that the majority of groundwater in the mining area was infiltrated during the Holocene and late Pleistocene epochs (paleowater) rather than being replenished by recent rainfall. Hydrochemical variations observed in samples collected during the wet season are generally attributed to the mixing of surface water and groundwater at fractures around the mine pit.
Amniocentesis not only increases the miscarriage risk but also causes long-term adverse perinatal outcomes
Authors: Golbasi Hakan , Bayraktar Burak , Golbasi Ceren , Omeroglu Ibrahim , Kuyucu Melda , Alkan Kaan Okan , Can Sevim Tuncer , Ekin Atalay
Published: August 2024

Background
This study aimed to evaluate the short- and long-term pregnancy outcomes of pregnant women who underwent amniocentesis.
Methods
In this retrospective cohort study, pregnancy outcomes of 2044 pregnant women who underwent amniocentesis and 7668 pregnant women who underwent non-invasive prenatal testing (NIPT) as a control group were evaluated using single center data. Perinatal outcomes of 377 amniocentesis and 2063 NIPT cases, whose birth data were available, were analyzed. Structural and genetic anomalies, maternal additional diseases and multiple pregnancies were excluded from the study. Pregnancy and perinatal outcomes, including fetal loss, preterm birth (PTB), pregnancy-induced hypertensive diseases (PIHD), low birth weight (LBW), small for gestational age (SGA), and low APGAR scores (< 7) were evaluated.
Results
Miscarriage (< 24 weeks) (0.68%) and intrauterine fetal demise (> 24 weeks) (0.88%) were significantly higher in amniocentesis cases (p = 0.005 and p < 0.001, respectively). PTB (< 37 weeks), extremely PTB (< 28 weeks), and late PTB (34–37 weeks) were higher in amniocentesis cases (p < 0.001, p = 0.011, and p < 0.001, respectively). Adverse neonatal outcomes, including SGA, LBW, and low APGAR scores (1st and 5th minutes), were higher in amniocentesis cases (p < 0.001, p = 0.014, and p < 0.001, respectively). There was no significant difference in PIHD between the two groups (p = 0.287).
Conclusions
Our findings showed that, apart from fetal loss, amniocentesis may lead to adverse perinatal outcomes such as PTB, LBW, SGA and low APGAR scores. However, further studies evaluating long-term pregnancy outcomes associated with the procedure are needed.
Disease prediction model: An efficient machine learning- based DNA classifier
Authors: MATHUR GARIMA
Published: August 2024

When it comes to health care, everyone is always eager to identify diseases in their early stages, but doing so might be difficult because of the lack of knowledge on the patterns of specific diseases since DNA contains most of the genetic blueprints, DNA sequence classification can be used to predict the existence of certain conditions accurately. There are several machine-learning techniques available to classify DNA sequences. Traits from known diseases are extracted to train the model for new, unknown diseases. The expansion of patients' access to digital platforms for early disease diagnosis through knowledge transfer to artificial neural networks eliminates the need for clinical equipment. To analyze the model, DNA samples of four well-known viruses—human respiratory viruses, lung cancer viruses, and papilla-maviruses (HPV)—are gathered from Genbank (NCBI). These samples are then compared with five existing methods using seven different parameters—specificity, accuracy, Matthews correlation coefficient, recall, precision, F1-score, area under the receiver operating characteristic (ROC) curve (AUROC), and area under the Precision-Recall (PRC) curve (AUPRC)—to facilitate the analysis of the model. The outcome demonstrates that the proposed work provides significantly better precision and accuracy than the prior best results, where precision has increased by more than 5.124% and accuracy has increased by about 15.9%.
Choledocholithiasis as a Cause of Spontaneous Common Bile Duct Perforation: From Myths to Reality. A Case Report
Authors: González Camila Arias , Gómez Paula María Jaramillo , Ospina David Alejandro González , Garces Álvaro Andrés Duarte , Duque Sergio Iván Hoyos
Published: August 2024

Introduction: Spontaneous common bile duct (CBD) perforation is a rare complication of choledocholithiasis. Typically, it's diagnosed during surgery, particularly exploratory laparotomy, in patients experiencing acute abdomen. Case description: We present a case of a 16-year-old female with no prior medical history except for a cesarean section two months prior, who presented to the emergency department with abdominal pain. During surgery, we diagnosed spontaneous CBD perforation due to choledocholithiasis and described the treatment. Discussion: Due to its low incidence, diagnosis of spontaneous CBD perforation is often delayed, leading to increased morbidity and mortality. Symptoms vary, and diagnostic imaging is nonspecific. Treatment choice between conservative and surgical approaches depends on patient hemodynamic stability, perforation characteristics, and CBD condition. Surgical options include bile duct repair or reconstruction. Conclusion: Spontaneous CBD perforation is rare and usually diagnosed during surgery. Treatment ranges from conservative measures to bile duct reconstruction.
Outcomes after revision of anatomic total shoulder arthroplasty to reverse shoulder arthroplasty and comparison between cemented or metal-backed glenoid in platform systems.
Authors: Zampeli Frantzeska , Kazum Efi , Gomez Alejandro , Valenti Philippe
Published: August 2024

Background
The objective of this study is to report the outcomes after revision of anatomical total shoulder arthroplasty (ATSA) to reverse shoulder arthroplasty (RSA) and to compare between groups depending on the primary ATSA glenoid implant type, cemented polyethylene (PE) versus a convertible metal-backed (MB). The hypothesis was that the outcomes would differ between patients treated with ATSA with PE and MB implants in favor of the platform system.
Methods
Group A included ten cases of convertible MB glenoid that were revised due to instability (six cases), posterosuperior rotator cuff tear (RCT) (two cases), subscapularis rupture (one case) and polyethylene dissociation (one case); Group B included ten cases of cemented PE that were revised due to glenoid loosening (six cases), RCT (two cases), dislocation (one case), and painful stiffness (one case). Active motion, Constant score, subjective shoulder value, Simple Shoulder Test and pain (VAS) were evaluated at minimum follow-up of two years. Student’s t test and Mann-Whitney tests were used for statistical analysis. Level of significance α=0.05.
Results
For the entire study cohort, postoperative results were improved compared to the preoperative state (p<0.05) at mean follow-up 60 months (24-188). Group A demonstrated improved postoperative pain levels compared to Group B (VAS 0.1 vs 1.9; p=0.004). No other differences were detected between the two groups (p>0.05). One complication occurred in Group B where one patient was re-operated for RSA instability with a good final functional outcome.
Conclusions
ATSA to RSA conversion resulted in improved functional outcomes. Post RSA motion and functional outcomes did not differ between the two groups with exception of reduced pain levels for patients treated with a convertible MB ATSA system.
Level of evidence: III; retrospective comparative study; treatment study
Comparison of the antiarrhythmic effects between hawthorn special extract WS® 1442 and magnesium/potassium using data from clinical practice in Germany: a retrospective cohort study
Authors: Wyss Christophe , Gündling Peter , Kostev Karel
Published: August 2024

Background: Hawthorn special extract WS® 1442 has beneficial effects on the cardiovascular system. Experimental studies showed an antiarrhythmic effect of the substance. We therefore investigated antiarrhythmic effects of WS® 1442 compared with magnesium/potassium in a large collective of outpatients.
Methods: Using the IQVIA® Disease Analyzer (DA) database, we included 4,550 patients with a prescription of WS® 1442 and 4,550 matched patients with Tromcardin® prescriptions (all registered products under the trademark Tromcardin® that are magnesium and potassium supplementing foods for special medical purposes) who were followed for 5 years after the index date. The incidence of various cardiac arrhythmias (atrial fibrillation and flutter (AFF), tachycardia, and other cardiac arrhythmias) was recorded. Cox regression models were used to evaluate the potential association between both drugs and arrhythmias.
Results: The cumulative incidence of AFF was significantly lower among patients with WS® 1442 prescription compared to patients with magnesium/potassium prescriptions (10.8% vs. 16.4%, p<0.001). WS® 1442 prescription was significantly associated with a lower incidence of AFF compared to magnesium/potassium (HR: 0.71; 95%CI: 0.64-0.80; p<0.001). The cumulative incidence of tachycardia was significantly lower with WS® 1442 compared to magnesium/potassium (8.3% vs. 9.4%, p<0.001). Similarly, the cumulative incidence of other cardiac arrhythmias was significantly lower among WS® 1442 patients compared to patients with magnesium/potassium (10.2% vs. 14.8%, p<0.001).
Conclusion: In a large collective of outpatients, intake of WS® 1442 was associated with a significantly lower incidence of atrial fibrillation, tachycardia, and other cardiac arrhythmias compared to magnesium/potassium, indicating its potential in treating and preventing such conditions.
Sphk1/S1P pathway promotes blood-brain barrier breakdown after intracerebral hemorrhage through inducing Nlrp3-mediated endothelial cell pyroptosis
Authors: Guo Fu-You , Feng Mengzhao , An Yuan , Qin Qi , Fong Iat-Hang , Zhang Kaiyuan , Wang Fang , Song Dengpan , Li Mengyuan , Yu Min , YEH Chi-Tai , Chang Junlei
Published: August 2024

Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and limited therapeutic options. The blood-brain barrier (BBB) disruption post-ICH exacerbates secondary brain injury, highlighting the need for targeted therapies to preserve BBB integrity. This study aims to investigate the role of the Sphk1/S1P pathway in BBB breakdown following ICH and to evaluate the therapeutic potential of Sphk1 inhibition in mitigating this disruption. Using a combination of human patient samples, mouse models of ICH, and in vitro cellular assays, this study assesses the expression of Sphk1/S1P and its impact on BBB integrity. The Sphk1 inhibitor PF543 is utilized to explore the pathway's role in modulating Nlrp3-mediated endothelial cell pyroptosis. SiRNA targeting Sphk1 is utilized to examine the suppression of pyroptosis in brain endothelial cells (bEnd.3) following the knockdown of Sphk1. The results indicate significant upregulation of Sphk1/S1P in the peri-hematomal brain tissue after ICH, which correlates with increased BBB permeability. Pharmacological inhibition of Sphk1 with PF543 attenuates BBB leakage, reduces hematoma volume, and improves neurological outcomes in mice. Mechanistic insights reveals that Sphk1 inhibition preserves tight junction proteins and decreases endothelial transcytosis, stabilizing the BBB. Furthermore, Sphk1/S1P is shown to promote Nlrp3-mediated endothelial cell pyroptosis, with the protective effects of Sphk1 inhibition mediates through the ERK1/2 signaling pathway. The Sphk1/S1P pathway plays a critical role in ICH-induced BBB breakdown, and its inhibition presents a promising therapeutic strategy for ICH management. Targeting this pathway may offer a novel approach to reduce secondary brain injury and improve patient outcomes following ICH.
E. coli mediated Acute Suppurative Thyroiditis with Thyroid abscess in a patient with Urosepsis: Case report
Authors: Chakravarty Sharmistha , John Raima M , Ghosh Amritava
Published: August 2024

Introduction: Thyroid abscesses are rare modalities of infectious pathology of the thyroid gland. The thyroid is highly resistant to infection due to high iodine content, capsule, and rich vascularity. Acute suppurative thyroiditis represents less than 1% of thyroid diseases, but if present, could potentially lead to a life-threatening endocrine emergency.
Case Presentation: A 62 year-old elderly diabetic lady presented with complaints of sudden onset anterior neck swelling and difficulty in swallowing for a week. She had a history of Urinary Tract Infection leading to Acute Kidney Injury and Urosepsis twenty days back, which was managed conservatively by antibiotics. Bacteraemia from the urosepsis spread to thyroid gland leading to Acute Suppurative Thyroiditis and thyroid abscess. Patient developed acute onset painful enlargement of thyroid gland. Incision and drainage of the neck abscess was done along with left thyroid lobectomy and tracheostomy. She developed left vocal cord paresis postoperatively, but the hoarseness improved after three months. Regular dressing and parenteral antibiotics against E. coli resulted in complete wound healing in two weeks.
Conclusion: We found an association of urinary tract infection with thyroid abscess which was confirmed by E.coli positivity in thyroid abscess pus culture report and previous urine culture reports. In cases of acute suppurative thyroiditis with thyroid abscess, the primary source of infection should be searched and meticulously treated because in majority of cases it occurs due to bacteriological spread from a distant site in the body.
Histopathology and proteomics are synergistic for High-Grade Serous Ovarian Cancer platinum response prediction
Authors: Csabai István , Kilim Oz , Olar Alex , Biricz András , Madaras Lilla , Pollner Péter , Szallasi Zoltan , Sztupinszki Zsofia
Published: August 2024

Patients with High-Grade Serous Ovarian Cancer (HGSOC) exhibit varied responses to treatment, with 20–30% showing de novo resistance to platinum-based chemotherapy. While hematoxylin-eosin (H&E) pathological slides are used for routine diagnosis of cancer type, they may also contain diagnostically useful information about treatment response. Our study demonstrates that combining H&E-stained Whole Slide Images (WSIs) with proteomic signatures using a multimodal deep learning framework significantly improves the prediction of platinum response in both discovery and validation cohorts. This method outperforms the Homologous Recombination Deficiency (HRD) score in predicting platinum response and overall patient survival. The study sets new performance benchmarks and explores the intersection of histology and proteomics, highlighting phenotypes related to treatment response pathways, including homologous recombination, DNA damage response, nucleotide synthesis, apoptosis, and ER stress. This integrative approach has the potential to improve personalized treatment and provide insights into the therapeutic vulnerabilities of HGSOC.
Malaria Dynamics in Iran:Insights fromAutochthonous and Asymptomatic
Authors: Sadeghi Fatemeh , Nodez Seyed Mohsen Mohebbi , Khosravani Mousa
Published: August 2024

The global efforts to eradicate malaria infection are continuing. Certain countries were declared free status, while others ended up in the control or elimination phase. Primary data were collected from Hormozgan province CDC surveillance and control programs between April 2018 and May 2023. Health professionals entered the data of malaria patients into Microsoft Excel and separated them into two categories: public data (demographic and socioeconomic) and clinical symptoms relevant to our community, such as age, sex, nationality, occupation, residential status, and parasite species. More time was spent organizing them to run an accurate statistical test in SPSS. The study included 289 cases: 87.5% male, and 12.5% female; Most of them were 11–29 years old. Vivax malaria was found in 78.9% of the total study population, Afghans, Pakistanis, and Iranians (as autochthonous cases) with percentages of 56.7%, 30.8%, and 12.5%, respectively. In 2023, the number of cases reached its peak, especially in Jask County. 94.1% received treatment and 45.7% were asymptomatic. Imported malaria can indeed contribute to maintain malaria transmission among native populations and potentially increase autochthonous malaria cases. Their movement needs to be strictly monitored. To identify asymptomatic, a cost-effective approach that would be readily accessible to every spot is requested.