bluuebunny/crossref_metadata_2025 huggingface dataset:
Parameters of the UNIQUAC model for describing the vapor-liquid phase equilibrium of D2-T2, D2-DT, DT-T2 hydrogen isotope mixtures
Authors: Korotkova T. G.
Published: January 2023

Objectives. Determination of the parameters of the binary energy interaction of the (UNIversal QUAsiChemical) UNIQUAC model on the basis of mathematical processing of experimental literature data on the phase equilibrium of hydrogen isotopic mixtures D2-T2, D2-DT, DT-T2 to calculate the activity coefficients of the components D2, DT, and T2.

Methods. The method of successive approximations was used in junction with the “from stage to stage” method, which consists in calculating a single evaporation process on a theoretical plate.

Results. Equations were written for calculating the activity coefficients of hydrogen isotopes on the basis of the Sherwood theory as applied to binary D2-T2, D2-DT, DT-T2 and ternary D2-DT-T2 hydrogen isotope mixtures. The graphical dependences of the activity coefficients and separation coefficients of mixtures D2-T2, D2-DT, and DT-T2 are compared in the range of the concentration of a highly volatile component from 0 to 100 mol % at atmospheric pressure for three options: ideal mixtures; non-ideal mixtures using the Sherwood theory; non-ideal mixtures on the basis of the UNIQUAC model. The dependences of the separation coefficients a were found to be similar for all binary isotopic mixtures. However, when considering mixtures as ideal, a increases.

According to Sherwood's theory, a remains a practically constant value, which is independent of the composition of the mixture. The UNIQUAC model predicts a decrease in a with an increase in the concentration of a less volatile component in the mixture. The profile of the distribution of hydrogen isotopes D2, DT, and T2 of a three-component mixture D2-DT-T2, along the height of a distillation column operating in a closed mode was calculated for three variants. It was accepted that: pressure along the height of the column is constant and equal to atmospheric 760 mm Hg. Art.; number of theoretical plates 21; concentration of components in the liquid phase on the first plate (stage), in mol %: XD₂ = 65; XDT= 10; XT₂= 25; the accuracy of calculating the composition of the vapor phase is 10-10.

Conclusions. The parameters of the binary energy interaction of the UNIQUAC model of hydrogen isotopic mixtures D2-T2, D2-DT, and DT-T2 are determined. The UNIQUAC model is adequate in relation to experimental data on the coefficient of separation. Due to systematic deviations in the theoretical Sherwood and ideal models, they are not suitable for further calculations of phase equilibrium of isotopic mixtures of hydrogen D2-T2, D2-DT, DT-T2, and D2-DT-T2.
Gobernanza democrática en la nueva política de cooperación al desarrollo de la Unión Europea
Authors: De la Cruz Prego Fernando , Iribarren Iosu
Published: January 2023

En las últimas décadas la Unión Europea (UE) ha sufrido notables transformaciones que han afectado a su política exterior y por extensión a su política de cooperación al desarrollo. El nuevo enfoque de la Unión Europea implica importantes cambios, entre otros, en la sectorialización de su ayuda exterior. Este artículo analiza los efectos, tanto cuantitativos como cualitativos, que estos cambios pueden tener en el sector de la gobernanza democrática. Los resultados muestran que no se han producido cambios sustanciales, salvo por un enfoque reforzado de este tipo de programas en el ámbito bilateral y en que su dimensión más instrumental (“calidad institucional”) se concentra en los programas de ayuda financiera. La evolución de un incierto contexto internacional y la definición de las nuevas prioridades presupuestarias de la Unión en el año 2024 serán los factores determinantes que consoliden, o no, estas dinámicas.
Sickle cell disease phenotype. Relationship of haplotypes and polymorphisms in the β cluster, BCL11A and HBS1L-MYB. Pilot study
Authors: Ropero P. , Peral M. , Sánchez-Martínez L.J. , Rochas S. , Gómez-Álvarez M. , Nieto J.M. , González F.A. , Villegas A. , Benavente C.
Published: January 2023

Sickle cell disease (SCD), despite being a monogenic disease, presents a highly variable phenotype that essentially depends on the amount of fetal hemoglobin (HbF), constituting the main modulator of the disease. The variation of HbF levels between patients is genetically regulated.
HbF determines both the phenotype of the disease and the response to treatment with the main drug used, hydroxyurea. Researchers’ efforts have focused on discovering the genetic factors responsible for its variation; mainly describing the haplotypes of the β cluster and SNPs in three different loci: BCL11A, HBS1L-MYB and the β-globin cluster.
Objective: To determine, in a cohort of patients with SCD, the possible relationship between the number of SNPs and haplotypes with higher levels of HbF. A positive association could explain why certain haplotypes, such as Senegal or Arab-Indian, have higher levels. of HbF and less severe disease.
Methods: To verify this hypothesis, the characterization of the haplotypes was carried out using the PCR-RFLP technique and the genotyping of three SNPs representative of the three loci with the greatest association with the variation of HbF: XmnI (rs7482144), BCL11A (rs4671393) and HBS1L-MYB (rs9376092).
Results: A greater number of SNPs has been reported in the haplotypes related to higher HbF and a lower number in those with less HbF, although only the SNP XmnI (rs7482144) has shown a statistically significant association.
Conclusions: A direct relationship between haplotypes and the number of SNPs has been found, reporting that haplotypes with higher levels of HbF and thus a less severe phenotype, had a greater number of SNPs. Thus, the Benín and Bantu haplotypes traditionally associated with poor prognosis are the ones that have shown a lower number of mutated SNPs.
Penggunaan Media Sosial untuk Keselamatan Berkendara dalam upaya Membangun Kesadaran Tertib Berlalu Lintas pada Desa Telaga Murni,Kec.Cikarang Barat, Kab.Bekasi
Authors: Rahmawati Roselina , Pangesti Rendy Dwi , Mahbub Jamal , Isnubroto Danang
Published: January 2023

Media sosial adalah adalah alat komunikasi yang digunakan oleh pengguna dalam proses sosial. Keselamatan menurut Tim Redaksi Kamus Bahasa Indonesia (2008)  adalah merujuk pada suatu kondisi yang selamat dalam hal ini kondisi yang terbebas dari bahaya. Pengabdian kepada masyarakat ini mempunyai tujuan untuk menyelenggarakan Sosialisasi Keselamatan Berkendara Sebagai Upaya Membangun Kesadaran Tertib Berlalu Lintas Bagi Masyarakat Melalui Media Sosial. Kegiatan sosialisasi berupa ceramah ini dihadiri oleh 40 peserta. Diikuti oleh 27 orang ibu rumah tangga, 10 orang anak sekolah dan 3 orang balita. Dengan hal ini tampaklah sebanyak 68% kegiatan dihadiri oleh masyarakat usia produktif yang aktif dalam menggunakan internet untuk mengakses media sosial, yaitu ibu rumah tangga. Diharapkan peran aktif ibu rumah tangga yang telah mengikuti sosialisasi agar dapat mengedukasi keluarga selanjutnya untuk dapat menggunakan media sosial dengan baik. Adapun media sosial yang dapat diakses oleh masyarakat dalam hal keselamatan Berkendara dalam upaya Membangun Kesadaran Tertib Berlalu Lintas adalah Media sosial “rsaindonesia”, Media sosial “road_safety”, Media sosial “jddcroadsafety”, dan lain – lain.
Pemberdayaan UMKM “Kusuma Wijaya” Poncokusumo, Kabupaten Malang Melalui Penyediaan Infrastruktur Berupa Rak Besi Susun
Authors: Qosim Nanang , Emzain Zakki F , Monasari Ratna , Mufarrih AM , Raharjo Nain D , Safarudin Yanuar Mahfudz
Published: January 2023

Sarana yang representatif merupakan hal penting untuk menunjang kegiatan usaha di bidang penjualan kebutuhan pokok. Tampilan produk yang menarik tentu akan menarik minat konsumen untuk membeli. Usaha mikro, kecil dan menengah (UMKM) memiliki peran besar dalam perkonomian rakyat di Jawa Timur, tak terkecuali di Kabupaten Malang. Keberadaan UMKM selama ini mampu menjadi sumber nafkah masyarakat, terutama di pedesaan. Kelompok tenaga usaha mandiri “Kusuma Wijaya” merupakan UMKM yang beranggotakan masyarakat prasejahtera di desa Wonorejo, Kecamatan Poncokusumo. Karena keterbatasan modal untuk memulai usaha, anggota kelompok UMKM ini hanya menggunakan sarana seadanya untuk malaksanakan kegiatan usaha. Salah satu yang paling nampak adalah dengan meletakkan produk mereka di meja atau lantai teras. PPM ini dilakukan untuk merevitalisasi sarana UMKM tersebut melalui pembuatan rak besi siku berlubang untuk display produk sembako. Adanya kegiatan PPM ini diharapkan mampu mendorong pelaku UMKM untuk meningkatkan pendapatan usaha mereka. Ketersediaan sarana yang representatif sebagai tempat display produk, diharapkan dapat meningkatkan ketertarikan atau minat konsumen, serta memudahkan pelaku UMKM dalam menunjang kegiatan usaha mereka. Dalam kegiatan PPM ini telah dilakukan beberapa tahapan kegiatan yaitu survei lapangan, pembuatan alat, pelatihan penggunaan dan pernyerahan alat. Kegiatan PPM ini sejalan dengan Renstra PPM Polinema yaitu pemberdayaan koperasi dan UMKM melalui penyediaan insfrastruktur.
Histological Studies of Snails at Different Periods of Their Life Activity
Authors: Danilova I. S. , Fotina T. I. , Danilova T. M.
Published: January 2023

Large species of terrestrial mollusks are used for human consumption and are bred for this purpose. They have become a part of national cuisine in many countries. Histology is used in many fields of humane and veterinary medicine. Its main essence is that this method can diagnose the presence of formations and inclusions. It is used to determine this process's structure and stage of development. Samples of different tissues can be used as material for histological examination. The specialist analyzes and describes the histological preparations obtained after processing the material. Thus, we proposed a histological method of studying snails. This method can provide the data of snails’ state as a whole. Snails of the species Helix aspersa maxima, Helix aspersa muller, and Helix pomatia were the material for the study. Ten snails of each species were selected for the experiment at different periods: immediately after hibernation, five days after wakening, 14 days after wakening, and at the time of their active life – in July. First, we conducted histological studies of snails during their active life, i.e., in the summer months. Therefore, for this purpose, snails for the experiment were taken in July. It was determined that if the snail eats and has an everyday life, its digestive gland generally consists of digestive tubules separated by intertubular connective tissue containing hemolymphatic sinuses and hemocytes. Thus, in our research, we studied the structure of the digestive gland. A circular muscle layer surrounds each tubule. There are three different cell types in the epithelium lining the tubules of the digestive glands, which differentiate into digestive cells, calcium cells, and excretory cells. Digestive cells are the most numerous cellular component of the tubular epithelium of the digestive gland. Basally located nuclei of digestive cells have a round or oval shape. During the rest period, the digestive gland of snails is characterized by a complete loss of digestive function and the transformation of digestive cells into excretory ones. Metabolic products are not excreted into the environment. When they accumulate, they fill all cavities in the body of snails, namely the lumens of glandular tubules, excretory ducts, stomach, and intestines. Food intake in snails increases the level of metabolism. It stimulates the differentiation of digestive cells, the functional activity of excretory cells, and the volume of excretory products. It leads to the complete liberation of the digestive tract from accumulated excretion products during the rest period. The structure of the digestive gland is completely restored.
New opportunities in the paper and nonwovens industries with foam-assisted web forming and chemical application
Authors: OKSANEN ANTTI , HJELT TUOMO , LEHMONEN JANI , RANTANEN TIMO , ASIKAINEN JAAKKO , SALMINEN KRISTIAN
Published: January 2023

Foam-assisted web forming and chemical application technologies have great potential to improve manufacturing efficiency and product quality in the paper and nonwovens industries. In this study, the benefits of foam forming and foam-assisted application of chemicals were demonstrated in a pilot machine trial. Uniform high-bulk webs of unrefined bleached softwood kraft pulp (BSKP) and viscose fibers were manufactured by foam forming. It was shown that foam formed low-grammage and high-bulk viscose fiber webs can be strengthened by foam-assisted application of latex onto the wet web. Correspondingly, foam-assisted application of carboxymethyl cellulose (CMC) and anionic polyacrylamide (A-PAM) improved the strength of the foam formed low-grammage and high-bulk BSKP web. Overall, the pilot machine results indicated that material cost savings could be achieved and a high-performance product could be manufactured with foam-based technologies.
El fenómeno de la migración; una discusión conceptual sobre el derecho de los seres humanos a migrar
Authors: De León Vargas Georgina Isabel
Published: January 2023

En el presente texto se pretende estudiar al fenómeno de la migración como un movimiento social, económico y político, desde un abordaje conceptual tendiente a analizar el derecho de los seres humanos a la movilización libre autónoma y espontanea por los diferentes territorios del mundo, en aras de búsquedas de oportunidades de progreso y el mejoramiento de la calidad de vida, así como estudiar la responsabilidad de los Estados receptores de migrantes en su calidad de garante de los Derechos fundamentales del ciudadano que migra, se contextualiza igualmente el flagelo migratorio venezolano en Colombia y las garantías que estos tienen en el territorio colombiano.
Os Povos Originários No Brasil e o Marco Temporal para Demarcação de Terras como Retrocesso
Authors: Tibiriçá Amaral Sérgio , De Toledo Pennacchi Tibiriçá Amaral Maria Fernanda
Published: January 2023

A tese do “marco temporal” defende que somente os povos indígenas que comprovarem que possuíam as terras ou que seus ancestrais as habitavam em 05 de outubro de 1988, data da promulgação da Constituição, teriam direito a demarcação das terras. Essa tese, não leva em conta as diversas etnias, povos, línguas e culturas que existem espalhadas pelo Brasil. Além do mais, o conceito de posse para os povos indígenas é completamente diferente do conceito de posse trazido pelo Código Civil, pois, para o indígena, a conservação da terra é um modo de vida, que garante a subsistência e preservação da cultura indígenas, através da preservação da floresta. Diferentemente, do conceito trazido pelo Código Civil, que mercantiliza a terra para exploração de seus recursos naturais. É preciso lembrar que essas terras pertencem aos povos originários, eles são os reais donos das terras brasileiras, de modo que, não há que se falar em reintegração de posse em favor dos fazendeiros, e, ainda, caso houvesse uma eventual privatização das terras indígenas, esses povos deveriam ser indenizados, além de receber pela exploração econômica de suas terras. Portanto, é preciso distinguir os tipos de terras ancestrais, e a importância de sua regularização. Além do mais, a jurisprudência da Corte Interamericana corrobora o entendimento de que não deve existir um marco temporal para a ocupação indígena, tendo em vista que, ela é anterior a criação do próprio Estado Brasileiro.
Aportes del Derecho Romano a la tradición jurídica de occidente
Authors: Carrillo De La Rosa Yezid , Carrillo Velásquez Alfonso Fernando , Cano Andrade Ricardo Andrés
Published: January 2023

El presente texto aborda, a modo de ensayo, una revisión analítico-histórica del Derecho Romano y sus aportaciones sustanciales en la tradición jurídica de occidente. Así, sustenta la tesis de que existen otras instituciones y conceptos que han transcendido los contenidos del derecho privado para irradiar la práctica judicial y las instituciones básicas de la cultura jurídica en occidente.
The Statutes of the Youth Confraternity of the Purification of the Virgin Mary and of Saint Zenobius in Florence, 1444–ca. 1742
Authors: Newbigin Nerida
Published: January 2023

The illuminated statutes of the Florentine youth con­fraternity of the Purificazione, now in the Lilly Library of the University of Indiana, were approved by Archbishop Antoninus in 1448. They set out the key concerns of the confraternity: good governance in order to foster moral and spiritual rectitude in the brethren, entry into and departure from the group, duties towards the sick, the dying and the dead, and proper forms of devotion on ordinary Sundays and feast days. The Purificazione statutes also prescribe the performance of a rappresentazione for the confraternity’s principal feast day. The statutes are translated here for the first time.
Türkçeyi Yabancı Dil Olarak Öğrenen Öğrencilerin Türkçe Öğrenme Tutumları İle Türkçe Öğrenmeye Yönelik Motivasyon Engelleri Arasındaki İlişkiler
Authors: İNALÖZ Ahmet Buğra , YILMAZ Kürşad
Published: January 2023

Bu araştırmada Türkçeyi yabancı dil olarak öğrenen öğrencilerin Türkçe öğrenme tutumları ile Türkçe öğrenmeye yönelik motivasyon engelleri arasındaki ilişkilerin belirlenmesi amaçlanmıştır. Katılımcıların görüşleri ilk önce betimlemiş, çeşitli değişkenlere göre karşılaştırılmış, son olarak da iki değişken arasındaki ilişki belirlenmeye çalışılmıştır. İlişkisel tarama modelindeki araştırmanın örnekleminde 342 üniversite öğrencisi bulunmaktadır. Araştırmanın verileri “Türkçe Öğrenme Tutum Ölçeği” ve “Türkçeyi Yabancı Dil Olarak Öğrenenlere Yönelik Motivasyon Engelleri Anketi” ile toplanmıştır. Verilerin analizinde betimsel istatistikler, t-testi, tek yönlü varyans analizi ve Pearson korelasyon katsayısı kullanılmıştır. Elde edilen sonuçlara göre, katılımcılar yüksek düzeyde bir Türkçe öğrenme tutumuna sahiptir. Katılımcılar sıra ile en yüksek tutuma bilişsel, duyuşsal ve devinişsel boyutlarda sahiptir. Katılımcıların, bilişsel, duyuşsal ve devinişsel tutumları cinsiyete; duyuşsal tutumları eğitim alanına göre farklılaşmaktadır. Öğrenciler genel olarak düşük düzeyde bir motivasyon engeli hissetmektedir. En çok motivasyon engeli hissedilen konular sırasıyla, öğretmenlerin yetkinliği ve öğretme stilleri, öğrencilerin hisleri ile ilgili engeller, iletişim engelleri ve yetersiz materyal kullanımı ile ilgilidir. Katılımcıların öğrencilerin hisleri ile ilgili engeller, iletişim engelleri ve motivasyon engelleri toplam puandaki görüşleri cinsiyete; öğrencilerin hisleri ile ilgili engeller ve motivasyon engelleri toplam puandaki görüşleri ana dile; yetersiz materyal kullanımı ile ilgili görüşleri eğitim alanına göre istatistiksel olarak farklılaşmaktadır. Katılımcıların Türkçe öğrenme tutumu ve alt boyutları ile motivasyon engelleri ve alt boyutları arasında orta ve düşük düzeyde, ters yönde, anlamlı ilişkiler vardır.
Metafor ve Olgusal Gerçeklik Olarak Kripto Para Algısı
Authors: TECİM Erhan , YILMAZ Fatih , KARAKOYUNLU Murat
Published: January 2023

Ekonomik küreselleşme kripto varlıklar ile çok farklı bir niteliğe bürünmekte bireyler tarafından farklı şekillerde algılanabilmektedir. Bu nedenle, bu araştırma kripto varlıkların, yatırımcılar açısından ne ifade ettiğini ve bu bağlamda kamu otoritesinin nasıl konumlandığını ortaya çıkarmayı amaçlamaktadır. Bu araştırmanın temel problemi kripto varlıklar bireyler tarafından nasıl algılanmakta ve metaforik olarak nasıl temsil edilmektedir şeklindedir. Bu bağlamda kamu otoritesi, köşeyi dönme fikri, bireysel yatırım tercihleri, kripto paraya bakış ve dini tercihler şeklinde beliren temalar eşliğinde kripto varlıklara yönelik metaforik algılar ortaya konulmuştur. Uygun örnekleme tekniğinin benimsendiği bu araştırmada karma yöntem kullanılmıştır. Araştırmanın nicel verileri sabit format anket tekniği ile; nitel verileri ise açık uçlu görüşme tekniği kullanılarak Google formlar aracılığıyla gerçekleştirilmiştir. Nicel veri analizi esnasında temel istatistiki teknikler kullanırken; nitel veriler içerik analizi tekniği ile çözümlenmiştir. Çalışmanın en temel bulgusu olarak; kripto varlıklara karşı temel bir güvensizlik olduğu, yatırım amacı olarak kripto varlıkların klasik varlıklardan çok sonra yer aldığı ve genel olarak kumar şeklinde algılandığı ifade edilebilir.
Türk Kamu Yönetiminin Yakın Dönem Tarihsel Gelişimi Üzerine Değerlendirmeler
Authors: BAYANSAR Reha , ÖZER Mehmet Akif
Published: January 2023

Bu makalede Türk Kamu Yönetimini’nin yakın dönem tarihsel süreci değerlendirilmekte ve değişime ne kadar hazır olduğu sorgulanmaktadır. Bilindiği gibi son yıllarda dünyada yaşanan gelişmeler, kamu yönetiminin de yeniden sorgulanmasına neden olmuş; bu bağlamda yirminci yüzyılın başından itibaren kabul edilen teorilerin ve uygulanan yöntemlerin yerine özel sektör yönetim teknikleri ve pratikleri ile daha çok ortak paydada buluşan yeni kamu yönetimi anlayışının kendine yer bulmasına tanıklık edilmiştir. 1980 sonrası Türkiye’de yaşanan gelişmeler de dünya üzerinde yaşanan bu gelişmelerden bir hayli etkilenildiğini de gözler önüne sermektedir. Çalışmada bu kapsamda, Türkiye özelinde, kamu yönetimi disiplininin doğuşu, gelişimi ve bugününü iç ve dış faktörlerin etkileri dikkate alınmak suretiyle değerlendirilecektir. Öncelikle Osmanlı’dan günümüze Türk Kamu Yönetiminin köklerine bakılacak, ardından Cumhuriyetin ilanından sonra yaşanan gelişmeler ele alınacaktır. Bu teorik zemin oluşturma çabasından sonra, ülkede çok partili dönemde yaşanan gelişmeler, kamu yönetiminde reformlar süreci, yabancı uzman raporları, Devlet Planlama Teşkilatı’nın kurulması, bu dönemde yapılan projeler, 1980 sonrası yapısal dönüşüm politikaları ve son dönem kamu yönetimi reformları ayrıntılı bir değerlendirmeye tabi tutulacaktır.
Probiotics in dermatological and cosmetic products – application and efficiency
Authors: Hyseni Edita , Glavas Dodov Marija
Published: January 2023

The term “probiotics” has first been used in 1907 by Elie Metchnikoff. Since then, probiotics have been part of research not only in regards of digestive health, but also inflammatory diseases. Lately, there has been an increased interest of probiotic’s effects in skincare. The management of atopic dermatitis, acne, psoriasis, photo aging, skin cancer, intimate care, oral care, wound healing is getting harder each passing day, due to increased antibiotic resistance and other side effects of conventional therapy. Therefore, new ingredients have been investigated and probiotics have been proved to be effective in treating various skin conditions.
This review aims to evaluate the scientific evidence on topical and oral probiotics, and to evaluate the efficacy of cosmetic and dermatological products containing probiotics. Many studies have shown that skin and gut microbiome alterations have an important role in skin health. Although this is a new topic in dermatology and cosmetology, there have been some promising results in lots of research studies that the use of probiotics in cosmetic products may help improve the patient’s outcome. While oral probiotics have been shown to promote gut health, which influences the host immune system and helps treat different skin diseases, the mechanism of action of topical probiotics is not yet fully understood. Although the number of commercial probiotic cosmetic products released in the market is increasing and most of the studies have not shown any serious side effect of probiotics, further studies, in larger and heterogeneous groups are needed.
Teaching a Child with Autism to Identify 2D Objects to Increase Receptive Language
Authors: Mahmood Arshad , Mian Irfan , Toneatto Tony
Published: January 2023

Receptive language was targeted in a skill acquisition program to teach a six-year-old boy with autism to receptively identify 2D objects. The program involved teaching a set target list with various objects categorized under various everyday functions in the child’s life. The child was taught to identify objects in an array of three presented in front of the student. The program was run daily; generally, the trials were broken up into two sessions over the course of the morning. Once the child mastered the set of three objects, he would move to the next set of three objects. Mastered target objects were put onto maintenance schedules. The results demonstrate data from baseline, pretesting of a set of targets and skill acquisition over several weeks.
A Review of Genetics in Chronic Pain
Authors: Bilal Qarni , Meenal Agarwal , Mayank Gupta , Nick Knezevic Nebojsa , Alaa Abd-Elsayed
Published: January 2023

Chronic pain impacts up to 50 million Americans yearly, where hundreds of billions of dollars are spent annually treating pain. The burden on health care systems and patients emphasizes our need to further investigate chronic pain. In recent years, the advent of advanced genome sequencing technologies has enabled us to identify variations in genomic regions which might contribute to susceptibility to pain as well as individuals’ response to treatment. The purpose of this review is to better understand the complex and multifactorial pathophysiology of chronic pain. A deeper understanding of the genetics of chronic pain could have wide implications in the diagnosis of pain pathologies as well as pain management therapy. Methods: This review conducted a literature analysis on the genetics of chronic pain. The PubMed® search engine was used to research key words “chronic pain”, “pain management”, “pharmacogenomics”, “gene therapy”, and “individualized medicine”. This paper’s research focused on investigating studies that conducted hypothesis-free genetic studies and genome-wide association studies (GWAS). Data from our literature search was compiled into this review and analyzed to discuss strengths and weaknesses of the current literature, and to discuss future avenues of research. Results: Many gene loci and mutations were identified as being associated with chronic pain pathologies. Results from pertinent genetic studies as well as online gene databases were compared to one another to isolate significant associations between genetics, pharmacogenomics, and pain management therapy. Discussion: When reviewing the literature searches, we found that although individual studies found significant associations between specific genes and chronic pain pathologies, the results from these studies were unable to be replicated on a larger scale. The genetic data associated with chronic pain has yet to be replicated consistently in different studies on subjects of different ethnicities, geographical distributions, and socioeconomic statuses. Further research into the genetics of chronic pain is needed to make generalizable conclusions and implement them in clinical practice.
Perkembangan Lembaga Pendidikan Islam Kontemporer
Authors: Fiandi Arif , Ilmi Darul
Published: January 2023

Teachers have a very large contribution to the success of learning in schools. In addition, the teacher also plays a very important role in helping the development of students to achieve their life goals optimally. In the classroom the teacher carries out two main activities, namely teaching and learning activities and class management. Teaching activities are essentially the process of organizing and organizing the environment around students. Classroom management is a series of actions taken by the teacher in an effort to create positive, productive and innovative learning environment conditions so that the teaching and learning process can run according to its objectives. In other words, classroom management is an effort to empower class potential through a set of teacher skills to create a conducive, positive, and productive learning climate and control it if there is a disruption in learning to optimize the learning process so that satisfactory results can be obtained.
Psoriasis and Comorbidities
Authors: Kılıç Arzu , Cakmak Seray
Published: January 2023

Psoriasis is a chronic inflammatory disease which is a result of complex interactions between genetic, environmental, and immunological factors. Psoriasis is now accepted as a systemic disorder accompanied by comorbidities rather than simply a cutaneous disease. Psoriasis has been associated with a number of systemic diseases such as diabetes mellitus, obesity, hypertension, metabolic syndrome, cardiovascular mortality, psoriatic arthritis, Crohn’s disease, ulcerative colitis, pulmonary disease, psychiatric disorders, and malignancies referred to as comorbidities. Although the causal relationship between comorbidities and psoriasis has not been completely clarified yet, it seems that shared genetic susceptibility, common environmental factors, and/or overlapping inflammatory pathways may be potential biological links underlying this association. The presence of comorbid diseases is important since it is associated with a significantly reduced life span and a significant deterioration in life quality. It is also important to keep in mind that the comorbidities and drugs used to treat them have an impact on the choice of antipsoriatic treatment. Besides, systemic treatment of psoriasis with certain drugs may impact the comorbid conditions. Therefore, it is necessary for physicians to recognise these concomitant diseases early and to arrange management options. In this article, the current literature about psoriasis-associated comorbidities and treatment approaches will be discussed.
Skin Reactions Secondary to Anticancer Agents
Authors: Fabbrocini Gabriella , Izzo Rosanna , Panariello Luigia , Monfrecola Giuseppe
Published: January 2023

In recent decades, new chemotherapeutic agents have been introduced in cancer therapy. The skin is often the target for the toxicity of these drugs. Skin side-effects may decrease the compliance and the quality of life of these patients. To cure and to prevent these side-effects dermatologists can cooperate with oncologists. In this paper we propose a brief review of the main toxic skin events caused by chemotherapeutic agents, in particular linked to the epidermal growth factor receptor (EGF-R) inhibitor.
IL-12/23 in IBD: Making the Best Use of Available Evidence
Authors: Fricker Janet
Published: January 2023

Prof Ghosh presented data from the UNITI studies exploring ustekinumab in primary or secondary nonresponders to TNF agonists (UNITI-1) and conventional therapy failures (UNITI-2). The data demonstrate that ustekinumab shows higher efficacy in patients who have failed conventional therapy compared to those who have failed anti-TNF therapy. Further sub-studies showed similar efficacy for ustekinumab 90 mg every 8 weeks (q8w) and ustekinumab 90 mg every 12 weeks (q12w) subcutaneous (SC) regimens, except for in patients with high inflammatory burdens, who did better with q8w regimens. No new safety signals were identified for ustekinumab between Week 96 and Week 156, with overall rates of adverse events and serious adverse events being comparable to placebo. Rates of antibody formation remained low.

Dr Raine described two case studies involving Crohn’s disease patients treated with ustekinumab. The first case described a female patient with luminal Crohn’s disease who had secondary nonresponse to an anti-TNF with signs of intestinal and systemic inflammation.

The second case considered a patient with bio-naïve luminal Crohn’s disease who had a previous history of opportunistic infections (coughs, colds, and recurrent herpes simplex).

Prof Armuzzi presented the results of the induction part of the UNIFI study, which randomised patients with moderate-to-severe ulcerative colitis (UC) to placebo, ustekinumab 130 mg, or a weight-tiered ustekinumab dose (˜6 mg/kg). Results showed clinical remission at Week 8 was 5.3% for placebo, 15.6% for ustekinumab 130 mg intravenous (IV) (p<0.001), and 15.5% for ustekinumab at ˜6 mg/kg IV (p<0.001). Furthermore, ustekinumab IV induced clinical response and endoscopic and mucosal healing, improved health related quality of life, and had an adverse event profile consistent with known safety profiles.
Ice-Assisted Transcatheter Closure of Interatrial Shunts: Ten-Year Follow-Up
Authors: Gianluca Rigatelli Gianluca Rigatelli , Dell’Avvocata Fabio , Giordan Massimo , Magro Beatrice , Osti Sabrina , Rafagnato Paola , Tiribello Antonella , Tiberio Lorella , Buson Claudia , Cardaioli Paolo
Published: January 2023

Background. Intracardiac echocardiography (ICE) is rapidly becoming a necessary tool in the catheterisation laboratory. We sought to prospectively evaluate the effectiveness of ICE-aided transcatheter closure of interatrial shunts.

Methods. In a prospective 10-year registry, we enrolled 378 patients (mean age 48±13.7 years, 214 females) who had been referred to three different centres for catheter-based closure of interatrial shunts. All patients were screened with transoesophageal echocardiography (TOE) before the operation. Eligible patients underwent ICE study with mechanical Ultra-ICE probe (Boston Scientific Corp, USA) and closure attempt.

Results. After the ICE study and measurements, 23 patients did not proceed to transcatheter closure due to: unsuitable rims, atrial myxoma not diagnosed by pre-operative TOE, or inaccurate TOE measurement of defects more than 40 mm. The remaining 355 patients underwent transcatheter closure: TOE-planned device type and size were modified in 175 patients (49.3%). There were no cases of aortic or atrial erosion, device thrombosis, or atrioventricular valve inferences. Globally the rates of procedural success, pre-discharge occlusion, and major complications rate were: 99.1%, 93.3%, and 0%, respectively. On mean follow-up of 9.1±2.3 years, the follow-up occlusion rate was 98.7% with no long-term complications.

Conclusions. ICE-aided transcatheter closure of interatrial shunts appears to be safe and effective in adult patients thus, eventually minimising device size over and underestimation, and potential complications of balloon sizing and general anaesthesia.
Same-Day Discharge After Transcatheter Aortic Valve Replacement
Authors: Crepy D’Orleans Charles Crepy , Keegan Patricia , Devireddy Chandan M. , Grubb Kendra J.
Published: January 2023

Transcatheter aortic valve replacement (TAVR) has been established as an alternative to surgical aortic valve replacement in select patients with severe aortic stenosis. Next-day discharge (NDD) after TAVR allow patients rapid mobilisation to return home. A minimalist pathway using NDD has been shown to be effective and safe in carefully selected patients. Following the COVID-19 pandemic and earlier reports of same-day discharge (SDD) after TAVR, in 2020 several institutions modified NDD protocols to carefully select patients for discharge the same day. These protocols maximised efficiency and resource utilisation while minimising COVID-19 exposures, hospital length of stay, and healthcare-associated costs, both to the institution and to the patient. In this literature review, the authors discuss the precedent for SDD after TAVR, investigate the pressure for efficiency amidst a global pandemic, and assess the safety and feasibility of SDD as seen across multiple healthcare systems.
Acute Bacterial Skin and Skin Structure Infections: Advantages and Disadvantages of Early Discharge and Outpatient Parenteral Antibiotic Therapy
Authors: Roberts Eleanor
Published: January 2023

Acute bacterial skin and skin structure infections (ABSSSI) can require long periods of antibiotic therapy. If an ABSSSI is treated while a person is in hospital, this may lead to an extended hospital stay of days or even weeks, even if the patient is in a stable enough medical condition to be discharged to their home environment. As such, inpatient treatment of an ABSSSI can incur high costs for the hospital and tie up beds that could be used for other patients. Michael Wilke from Inspiring-health GmbH, Munich, Germany, and the Medical School Hamburg, Germany, discussed with the EMJ how early discharge may be viable for patients who are medically stable and can either return to the hospital for daily treatment with intravenous (IV) infusions or are able to, reliably, take oral antibiotics. Also available are the long-acting antibiotics oritavancin and dalbavancin. The latter is administered only once via IV infusion. While the cost per dose of dalbavancin is more expensive than most oral or daily/twice daily IV antibiotic regimens, its use can facilitate early discharge, leading to reduced hospital stays and offset cost savings. Due to the administration schedule, the use of long-acting antibiotics circumvents issues with daily medication adherence.
Implications of the First Ex Vivo Gene Therapy Approved for Treating Early-Onset Metachromatic Leukodystrophy
Authors: Boyes Bronwyn
Published: January 2023

Laura Campbell from Orchard Therapeutics, London, UK, opened the session by explaining the objectives of the symposium and providing some background information on metachromatic leukodystrophy (MLD). MLD is a rare and life-threatening inherited disease of the body’s metabolic system. MLD is caused by a mutation in the ARSA gene, which results in the accumulation of fats called sulfatides in the brain and other areas of the body, including the liver, gallbladder, kidneys, and spleen. Over time, the nervous system is damaged and children with MLD experience progressive neurological symptoms, including motor, behavioural and cognitive regression, severe spasticity, and seizures. Patients with MLD gradually lose the ability to move, talk, swallow, eat, and see. MLD is estimated to occur in approximately one in every 100,000 live births.1,2 The prognosis for MLD is extremely poor. Most children within the late infantile (LI) form die by the age of 5 years; the juvenile (JU) form progresses to death within 10–20 years; and those affected by the adult form typically die 25 years following the onset of symptoms.1 Approval of Libmeldy (atidarsagene autotemcel, [arsa-cel]; Orchard Therapeutics, London, UK), a gene therapy containing an autologous CD34+ cell enriched population, which contains haematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human ARSA gene, for the treatment of early-onset MLD,3 opens up tremendous new possibilities for eligible children with MLD faced with this devastating disease, where previously no approved treatment options existed. Libmeldy is the first product approval for Orchard Therapeutics, a global gene therapy leader dedicated to rare diseases through the development of gene therapies.4 Francesca Fumagalli from the Paediatric Immunohematology Unit and Department of Neurology, Ospedale San Raffaele – Telethon Institute for Gene Therapy (OSR-TIGET), Milan, Italy, shared the evidence on the efficacy and safety of Libmeldy in patients with MLD. The clinical trial investigating Libmeldy started more than 10 years ago at OSR-TIGET. Campbell closed the symposium by providing several educational resources to support clinicians managing children with MLD.
Fundamental Principles of Raising an Antitumour Immune Response in Vivo: A Complex Model, a Case Report, and a Perspective
Authors: Scholl Suzy M.
Published: January 2023

In preclinical model systems, the fundamental principles underlying a successful and durable anti-tumour immune response are well demonstrated. In clinical practice, significant successes in Phase III trials have been few over the last decades, but the field has gained tremendous interest following recent advances showing the activity of checkpoint blockade inhibitors. Still, at this time we do not fully understand why some people respond while others do not; nor do we completely understand which clinical and immunological monitoring tools we need to put in place to make immunotherapy a more controlled medical science. Reviewing recent evidence suggests that for a successful and controlled immunotherapy, we may need to juggle with several conditions at the same time; there is a need for the endogenous or exogenous addition of tumour antigens for a favourable tumour microenvironment, and for an immune system which remains actionable towards T cell (effector) activity by checkpoint blockade inhibitors.
Prostate Cancer and Inflammation: The Role of miRNAs
Authors: Davidsson Sabina , Carlsson Jessica
Published: January 2023

Approximately 15-20% of all human cancers are assumed to be a result of infection and chronic inflammation due to a constant supply of cytokines and reactive oxygen species, giving rise to genomic instability and a subsequent tumour development. In recent years, chronic inflammation has also been hypothesised to influence prostate carcinogenesis, since both acute and chronic inflammation is commonly seen in prostatic tissues. The signalling pathways involved in the immune response and tumour development are overlapping with each other, and it has been proposed that miRNAs are a possible link between the two processes. In this review, we are describing some of the miRNAs which could constitute a conceivable link between inflammation and prostate cancer.
Evidence-Based Treatment Planning in mCRC: The Key to Maximising Outcomes
Authors: McEvoy Linda
Published: January 2023

This Roche sponsored satellite symposium was held as part of the European Cancer Congress 2013, and reviewed the current evidence available on treatment options for metastatic colorectal cancer and the application of this evidence to clinical practice.
Differenciating the Depths: A ‘Jungian Turn’ in Deleuze and Guattari Studies
Authors: Maxwell Grant
Published: January 2023

Although it is not clear that Deleuze and Guattari were simply and unambiguously Jungians, they extensively engaged with Jung’s depth psychology in both affirmative and critical ways. It is striking that Deleuze expresses a strong affinity between his work and that of Jung in several texts; Jung’s influence on Deleuze has not tended to be emphasised by scholars, though there is a rapidly growing ‘Jungian turn’ in Deleuze and Guattari studies. This article briefly extracts the influence of Jung on Deleuze and Guattari and, more extensively, explores profound resonances between Deleuze's Difference and Repetition and James Hillman's Re-Visioning Psychology.
Pengembangan UMKM pada Destinasi Wisata Kecamatan Cimenyan Kabupaten Bandung
Authors: Elsye Rosmery
Published: January 2023

Penelitian ini dilakukan dengan tujuan mengetahui sejauhmana pengembangan obyek wisata berdampak kepada keberadaan UMKM di Kecamatan Cimenyan. Penelitian ini menggunakan metodelogi kualitatif dengan analisis diskriptif, sumber data diperoleh dari data primer dan sekunder. Data primer data yang diperoleh dari hasil observasi dilapangan secara langsung, mewancarai beberapa nara sumber yang dapat memberikan informasi, data sekunder didapat dari buku-buku pustaka, dokumentasi-dokumentasi, serta Undang-Undang dan peraturan-peraturan terkait dengan Destinasi Wisata, UMKM dan makanan tradisional. Hasil penelitian menunjukkan bahwa pengembangan destinasi wisata di Kecamatan Cimenyan, pengembangannya disesuaikan dengan potensi-potensi obyek wisata yang ada saat ini, dengan menyempurnakan dukungan sarana dan prasarana serta infrastruktur jalan menuju kelokasi wisata di Kecamatan Cimenyan. Guna dapat mempermudah para wisatawan berkunjung kelokasi wisata di Kecamatan Cimenyan Kabupaten Bandung. Dengan disempurnakannya dukungan sarana dan prasarana serta penyempurnaan insfrastruktur jalan, menuju destinasi wisata di Cimenyan, semakin banyak pengunjung yang datang, dan dampaknya, semakin tumbuhnya UMKM-UMKM yang berdagang, untuk menjual produk-produk yang hasilkan dari masyarakat sekitar Cimenyan.
Strategi Pengembangan Pariwisata Berkelanjutan di Hutan Lindung Desa Sesaot Kecamatan Narmada Kabupaten Lombok Barat
Authors: Al Asy’ary Muhammad Shofiyan , Sundari Sri
Published: January 2023

Masih terjadi permasalahan dalam pengembangan pariwisata berkelanjutan di Hutan Lindung Sesaot. Antara lain: (1) Rendahnya kualitas sumber daya manusia; (2) Kurangnya sarana dan prasarana berupa aksesibiltas jalan menuju lokasi yang masih sempit; (3) Masih adanya perambahan hutan secara liar. Tujuan penelitian ini adalah untuk mengetahui bagaimana strategi Dinas Pariwisata Kabupaten Lombok Barat dalam pengembangan pariwisata berkelanjutan di Hutan Lindung Sesaot. Penelitian ini merupakan penelitian kualitatif dengan menggunakan metode deskriptif melalui pendekatan induktif. Teknik pengumpulan data dilakukan dengan cara wawancara, observasi dan dokumentasi. Teknik analisis data yang digunakan adalah analisis SWOT yaitu Strenght (Kekuatan), Weakness (Kelemahan), Opportunities (Peluang), Threats (Ancaman). Berdasarkan hasil penelitian diketahui bahwa pengembangan pariwisata berkelanjutan di Hutan Lindung Sesaot dipengaruhi oleh 6 dimensi yaitu (1) Seleksi mendasar terhadap permasalahan, (2) Menetapkan tujuan dasar dan sasaran strategis, (3) Menyusun perencanaan tindakan, (4) Menyusun rencana pemberdayaan, (5) Mempertimbangkan keunggulan, (6) Mempertimbangkan keberlanjutan. Namun dimensi menetapkan tujuan dan sasaran strategis dan menyusun perencanaan tindakan belum efektif karena masih sulitnya merubah pola pikir masyarakat setempat. Oleh karena itu Dinas Pariwisata Kabupaten Lombok Barat memberdayakan masyarakat setempat dan membuat paket wisata yang dikelola oleh masyarakat setempat. Untuk mendukung hal tersebut, pemerintah Lombok Barat juga telah menyusun regulasi terkait dengan Pariwisata Berkelanjutan.
The Analysis of Aceh Law and Its Relevancy on National Law from Human Right Perspective
Authors: Darma Nagara Muhamad Rizki Nugraha , Hendiyani Mesy Faridah
Published: January 2023

Islamization took place before the era of colonialization in Indonesia. Based on Law Number 22 of 1999, the local government has the authority to conduct some policies and consider the demands of the majority of individuals, for instance, bind them by implementing some Sharia laws, to find the better policy for all groups of people, and do not neglect the demands of the minority. Aceh is one of the provinces which is implementing Sharia law in form of Qanun Jinayat or Aceh regional law. Even though Aceh has the right to establish Sharia law, they have to be integrated into our national law. Up until now, the implementation of the Aceh law led to big attention from the international community, especially from human right activist and scholars. It is still a fruitful discussion among scholars and politicians in Indonesia. In this paper, the author discusses the analysis regarding the relation of Canon Law or Qanun with national law as well as the explanation of the Memorandum of Understanding between the Indonesia government and with Free Aceh Movement (GAM). It results that Qanun is not following Indonesia Law from a human rights perspective.
QUESTÃO DE ESTILO
Authors: Hipólito de Assis Adriana Carolina
Published: January 2023

O presente trabalho tem por objetivo observar a questão do estilo no design de moda ou de qualquer forma de expressão artística no campo do real lacaniano. A moda, assim como o design, são objetos de investimento simbólico, de linguagem cultural que possibilita nas trocas sociais a utilização do estilo como marca identitária, comportamental e de status. O estilo está associado à retórica e à estética. Na concepção lacaniana, o estilo está relacionado a linguagem inconsciente, ao Outro e ao objeto a enquanto causa do desejo. O estilo será ao mesmo tempo o analísta e o designer que busca montar bases para construção de seus objetos, assim como o próprio objeto de arte.