bluuebunny/crossref_metadata_2025 huggingface dataset:
Ovarian clear cell carcinoma with or without endometriosis origin in a single institution cohort
Authors: Sun Mingming , Jiang Wei
Published: February 2023

Background
As ovarian clear cell carcinoma (OCCC) has distinct clinical features, biology, genetic characteristics and mechanisms of pathogenesis, and whether the origin of endometriosis or not affects the prognosis of OCCC remains controversial.
Methods
We retrospectively collected medical records and follow-up data of patients with OCCC treated at the Obstetrics and Gynecology Hospital of Fudan University from January 2009 to December 2019. Further, we divided patients into 2 groups. Group 1: non-endometriosis origin; Group 2: endometriosis origin. Clinicopathological characteristics and survival outcomes were compared between the 2 groups.
Results
A total of one hundred and twenty-five patients with ovarian clear cell carcinoma were identified and included. In the overall patients’ population, the 5-year overall survival was 84.8%, the mean overall survival was 85.9 months. The results of the stratified analysis showed that early stage (FIGO stage I/II) OCCC had a good prognosis. The results of univariate analyses indicated that a statistically significant relationship between overall survival (OS) and FIGO stage, lymph node metastasis, peritoneum metastasis, chemotherapy administration methods, Chinese herbal treatment, molecular target therapy. As for progression-free survival (PFS), a significant relationship between PFS and child-bearing history, largest residual tumor size, FIGO stage, tumor maximum diameter, lymph node metastasis was found, respectively. FIGO stage and lymph node metastasis are common poor prognostic factors affecting OS and PFS. The multivariate regression analysis revealed that FIGO stage (p = 0.028; HR, 1.944; 95% CI, 1.073–3.52) and treatment by Chinese herbs (p = 0.018; HR, 0.141; 95% CI, 0.028–0.716) were identified as influencing factors with regard to survival. The presence or absence of lymphadenectomy did not affect OS of 125 OCCC patients (p = 0.851; HR, 0.825; 95% CI, 0.111–6.153).
Mean curvature flow solitons from the symmetry group viewpoint
Authors: Han Xu , Hou Zhonghua
Published: February 2023

The symmetry group of the mean curvature flow in general ambient Riemannian manifolds is determined, based on which we define generalized solitons to the mean curvatureflow. We also provide examples of homothetic solitons in non-Euclidean surfaces and prove that all the affine solutions to the mean curvature flow are self-similar solutions.
Geochemistry and P-T pseudosection modelling of two-pyroxene mafic granulite from Sonapahar, Shillong Meghalaya Gneissic Complex (SMGC), India: Implication for tectono-metamorphic evolution
Authors: Mahanta B. , Prakash D. , Kumar M. , Singh S. , Pandey R. K. , Singh C. K.
Published: February 2023

Granulites exposed in high-grade regional metamorphic belts and exhumed as xenoliths in basaltic pipes are considered as window into the deep crust thus play a key role in constraining models of crustal processes and evolution. Understanding granulites not only helps us place limits on the nature and composition of the lower crust in the existing continents, but it also sheds light on the crucial tectonic and chemical processes that lead to the accretion and eventual stabilisation of present crust dynamics, which in turn endorse continental growth. The study area, Sonapahar situated in the central portion of Shillong Meghalaya Gneissic Complex (SMGC) contain rich assemblage of different metamorphic rocks ranging from amphibolite to granulites. Unlike pelitic granulite, which receive much attention throughout the world, this work primarily focus in constraining the metamorphic evolution of two-pyroxene mafic granulite, which lack proper documentation hereto. Here we construct for the first time the P-T evolution of two-pyroxene mafic granulite from the Sonapahar, SMGC. Metamorphic P-T conditions estimated for the mafic granulite using conventional thermobarometer and winTWQ shows temperature in excess of 800 OC and pressure of about 9 kbars, stand for high temperature granulite facies metamorphism. The metamorphic evolution path continuing from prograde, peak to post-peak is obtained by constructing P-T pseudosection using Perple_X software in NCKFMASHTO system. Result suggest a clockwise P-T evolution path, thus signify isothermal decompression and indicate rapid upliftment prior to cooling of the tectonically thickened crust. Geochemical study of trace and REE, further suggest protolith is of tholeiite basalt in nature that is derive from hybrid (VAB+MORB) tectonic setting.
Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq
Authors: Kim Hugo , Saikia Junmi , Monte Katlyn , Ha Eunmi , Romaus-Sanjurjo Daniel , Sanchez Joshua , Moore Andrea , Hernaiz-Llorens Marc , Chavez-Martinez Carmine , Agba Chimuanya , Li Haoyue , Lusk Daniel , Cervantes Kayla , Zheng Binhai
Published: February 2023

The corticospinal tract (CST) is clinically important for the recovery of motor functions after spinal cord injury. Despite substantial progress in understanding the biology of axon regeneration in the central nervous system (CNS), our ability to promote CST regeneration remains limited. Even with molecular interventions, only a small proportion of CST axons regenerate1. Here we investigate this heterogeneity in the regenerative ability of corticospinal neurons following PTEN and SOCS3 deletion with patch-based single cell RNA sequencing (scRNA-Seq)2,3, which enables deep sequencing of rare regenerating neurons. Bioinformatic analyses highlighted the importance of antioxidant response and mitochondrial biogenesis along with protein translation. Conditional gene deletion validated a role for NFE2L2 (or NRF2), a master regulator of antioxidant response, in CST regeneration. Applying Garnett4, a supervised classification method, to our dataset gave rise to a Regenerating Classifier (RC), which, when applied to published scRNA-Seq data, generates cell type- and developmental stage-appropriate classifications. While embryonic brain, adult dorsal root ganglion and serotonergic neurons are classified as Regenerators, most neurons from adult brain and spinal cord are classified as Non-regenerators. Adult CNS neurons partially revert to a regenerative state soon after injury, which is accelerated by molecular interventions. Our data indicate the existence of universal transcriptomic signatures underlying the regenerative abilities of vastly different neuronal populations, and further illustrate that deep sequencing of only hundreds of phenotypically identified CST neurons has the power to reveal new insights into their regenerative biology.
Genotype-Environment Interaction in ADHD: Genetic Predisposition Determines the Extent to Which Environmental Influences Explain Variability in the Symptom Dimensions Hyperactivity and Inattention
Authors: Schwabe Inga , Jović Miljan , Rimfeld Kaili , Allegrini Andrea G. , Berg Stephanie M. van den
Published: February 2023

Although earlier research has shown that individual differences on the spectrum of the attention deficit hyperactivity disorder (ADHD) are highly heritable, emerging evidence suggests that symptoms are associated with complex interactions between genes and environmental influences. This study investigated whether a genetic predisposition for the symptom dimensions hyperactivity and inattention determines the extent to which unique-environmental influences explain variability in these symptoms. To this purpose, we analyzed item-level scores of 2168 twin pairs who completed both the Strengths and Difficulties Questionnaire (SDQ) and the Strength and Weaknesses of ADHD Symptoms and Normal Behavior (SWAN) questionnaire. To maximize the psychometric information to measure ADHD symptoms, psychometric analyses were performed to investigate whether the items from the two questionnaires can be combined to form two longer subscales. In the estimation of genotype-environment interaction, we corrected for error variance heterogeneity in the measurement of ADHD symptoms through the application of item response theory (IRT) measurement models. Results indicated that unique-environmental influences were more important in creating individual differences in both hyperactivity and inattention for twins with a genetic predisposition for these symptoms than for twins without such a predisposition.
A note on equality-constrained continuous optimization within the quantum approximate optimization framework
Authors: Zhang Yabin , Stokes James , Gorisch David , Jayakumar Paramsothy , Veerapaneni Shravan
Published: February 2023

The possibility of controlling the evolution of a quantum wavepacket to achieve optimization of a high-dimensional continuous function has been proposed and subsequently experimentally demonstrated in optical quantum hardware. In this short note we clarify how existing proposals for constrained continuous optimization are subject to instabilities which result from a Hamiltonian whose spectrum is unbounded in both directions. In addition we offer an alternative algorithm which is free from instabilities with potentially improved shot efficiency.
Data mining-based analysis of the application traits and dispensing patterns of borneol containing patented Chinese medicines
Authors: Zhong Ye , Qi Yue , Jiang Zhilan , Hu Yongsheng , Wu Chunxing , Wang Bolong , Zhang Xiao , Wang Zetian
Published: February 2023

Background: To give references for the clinical application of borneols and innovative medication development, as well as to reveal the dose pattern of patent Chinese medicines that contain borneols.
Methods: The database of proprietary Chinese medicines on Drugwise.com was searched for internal and external prescriptions that contained borneols and the diseases they treat. The frequency, taste, prescription, and association rules of the drugs were then analyzed using Microsoft Office Excel 2019 and SPSS Modeler 18.0 software, and the association rule display graphs were created using Origin21.0 software.
Results: The Chinese medicines with the highest frequency of borneol dispensing in
internal prescriptions were Niuhuang, Licorice, Zhu Sha, Musk, and Scutellaria, etc. The main treatment categories were primarily brain diseases and heart diseases, etc. There were 528 prescriptions for internal Chinese patent medicines containing borneols and 387 prescriptions for external Chinese patent medicines included. Menthol, camphor, frankincense, angelica, safflower, and other Chinese herbal remedies were used in combination with borneols more frequently in external prescriptions. Body ailments like paralysis, tumors, sores, ulcers, etc. were the primary treatment categories.
Conclusion: Both the internal and exterior borneol prescriptions have a cold and warm character, as well as a pungent and bitter flavor. The external prescriptions are mostly classified into the liver, heart, and spleen meridians, and are frequently combined with heat-clearing and blood-activating drugs to treat rheumatic paralysis and sores and ulcers. The internal prescriptions are mostly classified into the heart, liver, and lung meridians. They are often combined with sedative and detoxifying drugs to treat stroke, pediatric shock, and angina pectoris.
Empirical Green’s Function Simulations Toward Site-Specific Ground Motion Prediction for Kopili Fault of NER India
Authors: Bora Nilutpal , Das Sandip
Published: February 2023

We report new findings for producing broad-band ground motion time histories (1–19 Hz) of a future earthquake in a sedimentary basin based on the application of extended rupture modelling together with the use of empirical Green's functions (EGFs). This technique is used to model a MW 6.0 earthquake in Kopili fault zone (KFZ) north-eastern India (NER). We ran simulations for a sediment site (VS30 = 360 to 760 m/s) and a rock site (VS30 = 760 to 1500 m/s) to obtain the ground motion, which are then compared with a number of ground motion prediction equations (GMPEs). These GMPEs agree with the simulated ground motion amplitude, confirming that once we have precise source terms, the artificial ground-motions generated from earthquake scenarios of a specific site may be employed for seismic design safety in that given site. This work may open the door to additional in-depth, site-specific research in this area.
Functional and effective connectivity underlying semantic verbal fluency
Authors: Arrigo Isabella Velloso , Silva Pedro Henrique Rodrigues , Leoni Renata Ferranti
Published: February 2023

Semantic verbal fluency (SVF) impairment is present in several neurological disorders. Although activation in SVF-related areas has been reported, how these regions are connected and their functional roles in the network remain divergent. We assessed SVF static and dynamic functional connectivity (FC) and effective connectivity using functional magnetic resonance imaging in healthy participants. We observed activation in the inferior frontal (IFG), middle temporal (pMTG) and angular gyri (AG), anterior cingulate (AC), insular cortex, and regions of the superior, middle, and medial frontal gyri (SFG, MFG, MidFG). Our static FC analysis showed a highly interconnected network for task and resting state. Increased connectivity of AC with the pMTG and AG was observed for the task. The dynamic FC analysis provided circuits with connections similarly modulated across time and regions related to category identification, language comprehension, word selection and recovery, word generation, inhibition of speaking, speech planning, and articulatory planning of orofacial movements. Finally, the effective connectivity analysis provided a network that best explained our data, starting at the AG and going to the pMTG, from which there was a division between the ventral and dorsal routes. The SFG and MFG regions were connected and modulated by the MidFG, while the inferior regions formed the ventral route. Therefore, we successfully assessed the SVF network exploring regions associated with the entire processing, from category identification to word generation. The methodological approach can be helpful for further investigation of the SVF network in neurological disorders.
Study on wear resistance of implant abutment using different surface treatment methods
Authors: Wang Fang , Gu Hongzheng , Yang Bin , Zhu Zhen , Li Yongjian
Published: February 2023

Abrasion often happened in abutment screw during the operation of dental implant, and it often resulted in reduction of tightness between the abutment and the implant, which always caused the connection failure at last. The purpose of this in vitro study was to research the wear resistance of implant abutment screw under different surface treatment methods, and to find appropriate method to increase the wear resistance of implant abutment screw. Titanium abutments which were treated by low-temperature surface nitriding and low-temperature magnetron sputtering with TiN coating respectively were the experimental groups, and the untreated titanium implants and related abutments were used as the control groups. Wear resistance was obviously increased after low-temperature surface nitriding and low-temperature magnetron sputtering.
CAE-VLAD-Net: A Loop Closure Detection System for Mobile Robots Using Convolutional Auto-Encoders Network with VLAD
Authors: Liu Yanli , Li Yawei , Zhang Heng , Xiong Neal
Published: February 2023

A critical part of visual SLAM is visual loop closure detection. It can solve the problem of trajectory drift caused by long time movement of mobile robots. The traditional loop closure detection system can not accurately detect the real closed loop. Factors such as different viewpoints, different lighting conditions and dynamic feature occlusion can seriously affect the positioning accuracy of mobile robots. Deep learning is made significant strides in computer visual in recent years, offering a fresh approach to the closing loop detection challenge. In this paper, We build a loop closure algorithm based on CAE-VLAD-Net (Convolutional Auto-Encoder-Vector of Locally Aggregated Descriptors-Network) model, which can solve these problems. This algorithm combines the characteristics of convolutional neural networks and stacked auto-encoders in deep learning, extracts features of continuous dense data collected by sensors, and applies them in loop closure based on key frames. We conduct comprehensive tests on various datasets, demonstrating that our method performs better than the state-of-the-art approach.
Muscle Dysmorphic Disorder Inventory (MDDI): Translation and Validation of an Arabic-language version
Authors: AlGhareeb Muneera , Almutawa Yaser Mansoor , Karaidi Noor , Albalawi Rima , Aldwsri Alreem , Helmy Mai , Alenezi Ahmad F. , Trabelsi Khaled , Ghazzawi Hadeel Ali , Jahrami Haitham
Published: February 2023

Purpose
The term muscle dysmorphia (MD) refers to the pathological desire to increase lean muscle mass coupled with a persistent belief that one is not muscular enough. The disorder was recently classified under the umbrella of obsessive-compulsive disorder in DSM-5. The individuals social view and sense of self-worth are impacted by MD. Consequently, functional impairment occurs. The assessment of MD is made with the muscle dysmorphia Disorder Inventory (MDDI). The purpose of the study is to validate the Arabic version of the MDDI ensuring the availability of the instrument in Arabic-speaking nations.
Methods
1118 participants (58% female, average age 28 years) participated in the translation of MDDI through an internet-based survey.
Results
Based on multigroup confirmatory factor analysis (CFA), the three-factor structure of the English MDDI was replicated, independent of gender (TLI = 0.85, CFI = 0.90, RMSEA = 0.09). The reliability was evaluated via Cronbach's α and McDonald's ω for the total MDDI scale and the sub-scales. Cronbach´s alpha was 0.71 for DFS, 0.71 for AI and 0.82 for FI, and 0.70 for the MDDI total score. Men and women showed differences in three subscales of the MDDI (DFS, AI, FI). McDonald's Omega showed an Al of (0 .72) DFS (0.72) FI (0.83) and total MDDI (0.82).
Conclusion
The MDDI-13 Arabic translation proved to be valid. Thus, the results are consistent with using the measure in Arabic-speaking nations.
Level of evidence:
Level V descriptive cross-sectional study.
Big Data and Personal Information Privacy in Developing Countries: A Case of Kenya
Authors: Wambiri Daniel , Masinde Johnson , Mugambi Frankline
Published: February 2023

This study investigated the relationship between big data and personal information privacy in Kenya, a developing country where the use of big data has grown rapidly in recent years. The study aimed to assess the effectiveness of current data protection laws and policies, identify challenges faced by individuals and organizations in protecting their data privacy, and suggest ways to strengthen data protection frameworks and enhance public awareness of data privacy issues. The study used a mixed-methods approach, including a survey of 500 participants, 20 interviews with key stakeholders, and a review of 50 relevant documents.Based on the findings from the survey, interviews, and document review, the study found that there was a lack of awareness about the risks associated with sharing personal information online, and a need for greater public education and awareness-raising campaigns. The study also found that while individuals may be willing to trade their personal information for tangible benefits, they are also concerned about how their data is being used and by whom. Additionally, the legal and regulatory frameworks related to data privacy in Kenya were weak and fragmented, highlighting the need for stronger legal and regulatory frameworks and greater education and training for stakeholders. The study identified the need for cross-sectoral collaboration among government institutions, legal experts, industry representatives, and citizens to develop more nuanced and balanced policies and practices. The study has important implications for policymakers, industry representatives, and civil society organizations in Kenya and beyond, including the need for greater public education, stronger legal and regulatory frameworks, and greater dialogue and collaboration among stakeholders in the field.
A Deep Learning Method for Automatic Reliability Prediction of CR-VANETs
Authors: Bahramnejad Somayeh , Movahhedinia Naser , Naseri Amineh
Published: February 2023

Reliability is a critical issue in vehicular networks. A Deep Learning (DL) method is proposed in this study to automatically predict the reliability of Cognitive Radio Vehicular Networks (CR-VANETs) ignored in the previous research. First, a dataset is generated based on a previously proposed method for the reliability assessment of CR-VANETs. Then, a model is proposed to predict the networks' reliability using the DL method and compared with other machine learning methods. While machine learning methods have been applied in vehicular networks, they have not been used for reliability prediction. The proposed DL model is utilized in this research to predict CR-VANETs' reliability. Based on the results, the DL model outperforms other machine learning methods for reliability prediction. The correlation coefficient and root mean square error of the test data for the DL model are 0.9862 and 0.0381. These results indicate the CR-VANETs' reliability prediction accurately using the proposed method.
Environmental Risk Factors Contributing to the Transmission of COVID-19 in Zambia: A Cross-sectional study in Lusaka district
Authors: Chishimba Kennedy , Libonda Liyali , Velu Rachel Milomba , Kamboyi Harvey K. , Hakoonde Titus , Bumbangi Flavien Nsoni
Published: February 2023

Background: A propagative increase in SARS-CoV-2 transmission has been witnessed in Zambia since the index case was reported in March 2020. Although sociocultural factors including movement patterns, people’s livelihood, and way of life have been demonstrated to influence SARS-CoV-2 transmission dynamics, the role of environmental risk factors has not been adequately documented. The aim of the study was to investigate environmental risk factors contributing to the transmission dynamics of SARS-CoV-2 in Zambia using a cross-sectional study
Results: The positivity rates were 10.5 % cell phones, 5.3% door knobs, 2.7% remote controls and 2.6% beddings. All the other surfaces came out negative. The sex proportion of the respondents was 55% and 45% males and females respectively. Regarding occupancy density, 37.5% (15/40) resided in a 2 to 3-roomed house, 32.5% (13/40) resided in a 4 to 7 roomed house and 30% (12/40) resided in > 7-roomed house. Of the 40 respondents, 75% (30/40) used recyclable face masks while 25% (10/40) used non-recyclable face masks. For the non-recyclable face masks, 30% of the respondents indicated incineration as a disposal method. A correlation coefficient of 0.25 was documented for the association between occupancy density and surface contamination.
Conclusions: The study revealed that most environmental surfaces particularly mobile phones were rarely disinfected and were most likely to contribute to the transmission of SARS-CoV-2 in the community. Furthermore, the majority of the respondents used recyclable face masks which are easily washable. However, those who used non-recyclable face masks disposed of them indiscriminately which has the potential of contaminating the environment and further lead to the transmission of SARS-CoV-2.
The effect of exercise on breast cancer-related lymphedema
Authors: Yanxue Lian , Sandhu Simran , Yamikani Asefa , Gupta Ananya
Published: February 2023

Purpose: This review will provide an overview of the current state of knowledge by 1) evaluating the feasibility and safety of exercise as a treatment for patients with breast cancer-related lymphedema (BCRL), and 2) exploring the effects of different exercises on patients with BCRL.
Method: A systematic literature review of relevant studies published before 30 June 2022 was performed using three scientific databases PubMed, Embase, and Scopus.
Result: A total of 611 articles were found. Eventually, 15 articles fulfilled the inclusion criteria and were used for this literature review. A total of 5 different exercises, consisting of yoga, Pilates, resistance exercise, aquatic-based exercise, and complex exercise of aerobic and resistance training are included.
Conclusion: The review shows that these exercises are safe for patients with BCRL. Some measurable effects of exercises on lymphedema and some possible reasons/theories are shown.
Implications for Cancer Survivors: Although only yoga, Pilates, and resistance exercise may improve the severity of lymphedema based on the measurement of limb volume, all 5 exercise modes can help improve lymphedema symptoms to some extent. The improvement of symptoms may cause the increased quality of life (QoL) in symptom and physical functioning domains, leading to increased emotional and social function.
INFORMATION INTERNET RESOURCES IN THE SYSTEM OF PROVISION OF TRANSPARENCY OF PUBLIC AND LOCAL FINANCES
Authors: Zakharkin O. , Zakharkina L. , Kwilinski O. , Chukhno R.
Published: February 2023

The use of Internet information resources has become an integral part of the effective implementation of the principles of publicity and transparency of financial relations at the level of public, local, corporate and personal finance. The need for transparency of financial relations and the main goals of its implementation are enshrined in the Strategy for Digital Development, Digital Transformations, and Digitization of Public Financial Management until 2025 and approval of the action plan for its implementation, which was approved by the Cabinet of Ministers on November 17, 2021. This determines the relevance of research in this area. The aim of the work is to study the current state of implementation of digital technologies and resources aimed at ensuring the transparency of financial relations at the public and local levels. The article analyzes recent research and publications on the use of digital information technologies and resources in ensuring the transparency of financial relations and found that most researchers consider digital Internet resources as a key factor in implementing such transparency at the public and local levels. The analysis showed that the most widespread in Ukraine is the use of Internet information resources in the field of transparency of the budget process, taxation, and transparency of local finances. Today, the official source of public finance at the state and local levels is the web portal "Open budget", which was launched in 2018 at the initiative of the Ministry of Finance of Ukraine. The work also covered the activities of the official state web portal "Spending", which covers data on the targeted use of budget funds. The functional capabilities of the electronic office of the taxpayer are considered, which allows for an increase in the level of transparency in the tax sphere. The functional features and content of the website of Transparency International Ukraine, which is accredited by the global movement Transparency International and the information resource "Search and Analytical System .007", allows obtaining open data revealing the use of public funds, were also analyzed.
ANALYSIS OF THE POSSIBILITIES OF APPLICATION OF QUEST TECHNOLOGIES IN PROFESSIONAL ORIENTATION WORK
Authors: Rybalchenko S. , Balahurovska I. , Zahoruiko K. , Balahurovska A.
Published: February 2023

The development of modern Ukrainian education requires the use of fundamentally new tools of activity in the educational process. Focusing on the formation of a personality capable of independently solving situational tasks and making the most effective decisions is the task of a modern, competent teacher. A correctly chosen profession and the development of the necessary competencies and practical skills in the selected activity of each person form a developed and educated society. Such a society strives for growth in all social processes of the country, which in modern conditions needs highly qualified and modern specialists. Quest (web-quest) technology is one of the effective tools for the comprehensive development of students.
The paper describes the approaches of scientists to defining the essence and features of the quest (web-quest) technology. The forms of quests that solve various tasks with the help of the Internet, help students' personality development and help in career guidance activities are considered. Ways of implementing this tool in educational activities, which are aimed at creating conditions for high-quality training and career guidance activities that contribute to the correct choice of the future specialty of each member of society, are analyzed. The importance of using communication technologies when using the described technology is emphasized.
The article discusses the main tasks of the technology quest, the implementation of which ensures the development of the student's intellectual abilities and forms the necessary professional competencies for a particular activity. The role of the quest in the career guidance activities of education representatives is also considered.
The main competencies that develop during the use and implementation of quest technology in students and students have been studied. It was also analyzed how the combination of play and learning contributes to the effective interaction of the student with all elements of the educational process and the achievement of high results in education.
The pedagogical goals of implementing educational quests are described, contributing to the correct choice of a person's future specialty and practical training in the chosen activity.
Bioactivity of Hawthorn (Crataegus monogyna) and Heather (Calluna vulgaris) Leaf Tinctures: An Optimization Study Using Response Surface Methodology
Authors: KARAMAN Safa
Published: February 2023

In the current research, two medicinal important plants namely hawthorn (Crataegus monogyna) and heather (Calluna vulgaris) leaf were used for the tincture production according to central composite rotatable design and the produced tinctures were subjected to bioactive analysis to reveal the optimum manufacturing conditions. As response, total phenolic content and radical scavenging performance of the produced tinctures were analyzed. The levels of total phenolics and radical scavenging performance activity of the hawthorn and heather tinctures ranged between 2996.9-5415.8 mg GAE/L and 5514.9-13923.6 mg GAE/L and 26.9-71.9 and 51.0-94.1%, respectively. Effect of both liquid/solid ratio and ethanol concentration affected the bioactivity of the samples. Optimization process revealed that the optimum levels for the highest total phenolic content and antiradical activity were 4.03 mL/g for liquid/solid ratio and 67.07% for ethanol level for the hawthorn tincture and 4.03 mL/g for liquid/solid ratio and 53.77% for ethanol level for the heather tincture. The results of the current work revealed that the processing variables had important effect on the bioactivity of the tinctures.
Waste Characterızatıon of Karaman Provınce and Determınatıon and Comparıson of Indıvıduals' Waste Approaches
Authors: ARGUN Yusuf Alparslan , BİLGİN Melayib
Published: February 2023

The most basic building block of solid waste management is to determine the amount of waste generated by individuals in a day. As it can be understood from here, the most important issue in solid waste management is individuals. Therefore, all kinds of waste management studies should be based on the individual. In our study, a questionnaire was applied to 1 263 people residing in Karaman. In addition, according to income levels, 5 pilot regions were determined and characterization studies were carried out in different time periods. Of the wastes generated as a result of characterization, 45.08% of kitchen wastes, 3.41% of park and garden wastes and 30.36% of recyclable wastes. Only 18.6% of the recyclable waste potential is collected with the existing system. Within the framework of the survey, the rate of those who collect recyclable waste separately is 21%. In addition, it is understood from the survey study that individuals do not know what type of waste is produced in their homes. In this framework, waste collection and evaluation suggestions were presented by determining the waste potentials with the characterization study and the individual attitudes with the survey study.
Numerical Simulation of Coherent Extreme Ultraviolet Radiation by Considering Simple Hydrogen Atomic Potential
Authors: SAYRAÇ Muhammed
Published: February 2023

In this study, the ionization of a single electron exposed to an intense laser field is computed, and the nonlinear dipole response of a single electron is obtained. The ionization of a single electron exposed to an intense laser field can be computed using the strong field approximation (SFA), also known as the Keldysh theory. This method is based on the idea that the laser field is so strong that it can ionize the electron by tunneling through the Coulomb barrier. In this paper, the Xe, Ne, and H2 gas species are modeled since they have simple atomic systems. All gas species have relative or close ionization potentials. Ultra-short pulse duration (50 fs) is accepted because of the shorter time scale than the electron energy-lattice transfer. The ionization potentials of gas species result in the Keldysh parameter being smaller than one. The electron dipole oscillation spectra of these gas species are simulated by calculating the dipole spectrum considering the Lewenstein model. The electron propagation under the different wavelengths is simulated. The effects of the different driving wavelengths have noticeable effects on the enhancement and the extension of the extreme ultraviolet radiation signal.
Operating in international markets through cross-border e-commerce: A practitioners’ perspective
Authors:   St. Petersburg State University, Chen Shenglong
Published: February 2023

As the global business environment continuously evolves, the cross-border e-commerce becomes an essential part of international markets. This research analyzes practitioners’ perception of the cross-border e-commerce as an emerging channel to expand and operate in the global market and explores the platform structural performance determinants. We conducted the content and statistical analyses based on 35 interviews and constructed database of 150 observed companies. Deploying the springboard approach as the theoretical underpinning, we find the cross-border e-commerce optimal for companies to respond to the global turmoil in the short term and to achieve internationalization in the long term which serves as the most desirable option for firms to conduct cross-border commercial activities. The personalization in multiple language choices, reliable payment system settings, and clear website privacy commitment are the major factors. The diversity of language settings has the most significant positive influence on the cross-border e-commerce performance. This research contributes to the literature on the internationalization of firms and operation strategy in the global market enhancing the knowledge of operating crossborder e-commerce through the comparison with conventional internationalization paradigms and the examination of specific platform setting factors. International entrepreneurs can also benefit by understanding the practical specifications of the cross-border e-commerce and looking at platform structural performance determinants. The managerial implication suggested in this paper can be applied in their strategic decision-making which enhances a firm performance and helps to engage with the global economy.
Empedocles on the Inheritance of Parental Traits by Offspring
Authors:   S. I. Vavilov Institute for the History of Science and Technology of the Russian Academy of Sciences (St Petersburg branch), Pimenova Aleksandra A.
Published: February 2023

The paper deals with the embryological teaching of Empedocles, the ancient Greek philosopher from Acragas, who lived in the 5th century BC. The article is focused on the mechanisms by which children inherit their parents’ features in the doctrine of Empedocles. The available fragments and evidence on the teachings of early Greek philosophers often provide distorted and sometimes contradictory information. This paper attempts to carefully analyze all the evidence regarding inheritance mechanisms and bring it into an agreement with each other without resorting to abandoning some of the fragments. The most extensive information is provided to us by Censorinus, the 3rd century Roman writer, who in 238 AD wrote the treatise De die natali to congratulate his patron Caerelius on his 49th birthday. The article comments in detail on the testimony of Censorinus (De die natali, 6. 6 = 31 A 81 DK) concerning Empedocles’ views on the inheritance of parental traits by children, as well as the contradictory messages by Aetius (Aët. 5. 11. 1 = A 81) and Aristotle (De gen. an. I, 18, 723a23; IV, 1, 764a1f.; 765a 8 = 31 A 81 DK). The analysis conducted by Erna Lesky in her famous monograph of 1950 was expanded and supplemented in this article. In addition, the study takes into accountthe evidence of cases where children do not resemble their parents. Empedocles justifies these cases by popular superstitions, which were widespread in Europe up to the 20th century.
Four Hooves and a Horn: How (Not) to Poison Alexander the Great
Authors:   University of Belgrade — Faculty of Philosophy, Department of Classics, Tolić Isidora
Published: February 2023

Several ancient authors tell a puzzling story of treason to murder Alexander the Great by presenting him with poison or poisonous water carried in a curious vessel — a hoof of a horse, a mule, or an ass. Porphyry of Tyre, citing Kallimachos and Philo the Paradoxographer, gives us a reason to believe that the mention of hoof-made vessels was a misinterpretation of hornmade chalices, or put otherwise, drinking horns. Presuming that the vessel in question indeed was a drinking horn, we are left with an unusual image — Alexander the Great perished after drinking the poisonous water from the horn of a hornless animal. We can look into the development of this legend and propose its origins by examining mutual features of two distinct traditions — the Greek legend of the river Styx and its lethal streams and the Indo-Iranian tradition of several miraculous features of a unicorn’s horn, attested in Iranian, Indian, and Greek sources. After the survey of relevant sources, we see that the horn from Philo’s story represented a legendary present of Indian rulers intended to save Alexander the Great from harm. Various layers of misapprehension transformed the legendary gift into a device contracted to harm him. This way, the author demonstrates two points: 1) that the story told by Porphyry in Styg. 375F is a part of an Indo-Iranian tradition about unicorns and their miraculous features; and 2) that the legend of Alexander’s poisoning represents a transformed and misinterpreted story of Alexander’s grandest gift.
Cynthia and Propertius, Haemon and Antigone: Prop. 2. 8, 21–24
Authors:   St. Petersburg State University, Rossiyanova Kristina S.
Published: February 2023

The piece deals with the interpretation of Prop. 2. 8. 21–24. These verses seem to be problematic and illogical over the years. In the poem, the speaker, deserted by his beloved Cynthia, imagines himself dead and then describes the heroine’s reaction to this disastrous event. Propertius thinks that she will be happy about his death and defile his grave. Then he suddenly turns to Haemon, who commits suicide in despair of the Antigone’s death, and after that threatens Cynthia to kill her. Firstly, it is incorrect to compare the righteous Antigone with the unfaithful Cynthia. Secondly, the decision to kill the beloved is inept. Some scholarstranspose the verses in order to avoid the incoherence. Others try to interpret the passage, leaving the lines in their initial order, but they usually think that Propertius compares himself with Haemon and Cynthia with Antigone. The author of the article reconsiders gender roles in this comparison and suggests a new interpretation. There are also some examples from the Catullan and Propertian poetry, which show that the gender-inverted comparisons are widely used in ancient literature and especially in Roman love poetry of the 1st century B. C., in which they, probably, are part of a new literary strategy.
The article “Maxim Gorky as an Interpreter of Aristotle. Toward the Theory of Tragic Purification” written in 1929 by a A. A. Gruška a major Moscow Latinist and Wortphilologe of considerable renown writing, the last dean of the Department of History and Philology of Moscow State University, deserves the interest of scholars as a document of an era unhappy for Russian science. This curious verbose piece deals inter alia with the way M. Gorky “revealed through an extraordinary power of his literary prowess the very essence of the psychological process Aristotle understood under catharsis”. Gruška’s sketch went unnoticed in what was left of Classics in the 1920s Russia, the timing being exceptionally ill-chosen for any serious discussion of the kind. Analysing the careless way in which Gruška retells the seemingly pivotal for his article scene from Gorky’s story “Dreariness” (1896), one inadvertently comes to the conclusion that Gorky, Gruška’s favourite in the 1900s, by then had ceased to be of any considerable interest for Gruška, save for a nostalgic trip down the memory lane, while the article was written out of necessity and in haste, incorporating his miscellanea and Lesefrüchte to provide for what should be read between the lines.
Authors:   Department of Classics, Queen’s University, Griffith Robert Drew
Published: February 2023

Matro of Pitane’s cento of Homeric verses, The Attic Dinner Party contains a puzzling episode in which the narrator throws sea-urchins, which he has apparently already eaten, among the feet of the slaves, where they clatter “where waves were washing the beach”. The slaves then draw out the spines “from the head”. Following Elena Ermolaeva’s comparison of Matro’s lines to the Unswept Floor mosaic, I suggest that his banquet took place in a normal dining room rather than on a beach or in a room with a window facing one. The floor of this room, being a pebble mosaic, could aptly be called a beach from which the slaves were washing the detritus of the meal, a procedure (as we know from Olynthus) the dining rooms of private houses were expressly designed to facilitate. This interpretation entails reading *λύματ᾽… κλύζεσκον for the manuscripts’ κύματ᾽… κλύζεσκε). The scribal alteration I postulate has the effect — unique in this poem, and therefore suspect — of reproducing an entire Homeric line unaltered. Lastly, the phrase “from the head” does not refer to whence the slaves are pulling the sea-urchin’s spines (for that will be from their own feet), but to where they came from in the first place: a sea-urchin’s head.
Observance by religious employees of the requirements for appearance and business etiquette established by the employer
Authors:   St. Petersburg State University, Nogaylieva Fatima K.
Published: February 2023

In Russia, labor disputes are increasingly arising over the fundamental admissibility of employees observing the norms of the religion they profess, ethical teachings and the possibilities for obliging employers not to interfere with their observance by creating appropriate conditions for the use of labor. Law enforcement practice, in the absence of clear guidelines in the legislation, “disguises” such disagreements as disputes about dismissal for violation of labor laws, ignoring their true discriminatory nature. The article analyzes in detail one of the sections of the designated problem of reconciliation of labor and religion - the observance by religious workers of the requirements for the appearance and rules of business etiquette at the employer. Considering the problem, the author starts from the three main religious needs of the employee, which he seeks to satisfy in a controversial situation of contradiction between the employer's requirements and religious norms. Drawing extensively on materials from foreign practice and analyzing Russian legislation, the author comes to the following conclusions. The ability of an employee to satisfy a need such as the wearing of religious clothing, symbols, or other external manifestation of religious commitment will depend on what regulation is established by the employer in this regard. It also gives an assessment of the so-called policy of religious neutrality, established at the local level. As for the need for an employee to verbally express his religiosity and views, the employer has the right to prohibit such actions if they cause inconvenience to other employees or customers, threaten to lose customers, the image of the employer, and also to prevent proselytism in the team of employees. Finally, an employee for religious reasons may express a desire to refrain from participating in the employer's corporate events: coercion by the employer to the contrary clearly constitutes indirect discrimination.
Comparative legal analysis of the application of the principle of respect for the dignity of the employee
Authors:   Shanghai University of Political Science and Law, Sychenko Elena V. , Bobovnikova Emilia Yu. ,   LLC “Rosmedconsulting”
Published: February 2023

The purpose of this study is to analyze judicial practice on the application of the principle of respect for the dignity of an employee, enshrined in Article 2 of the Labor Code of the Russian Federation. In the absence of special rules on the protection of an employee from psychological harassment, abuse, and pressure on the part of the employer, this principle is the key to building the position of the plaintiffs. Unlike other principles, ensuring the right of workers to protect their dignity is limited to only two sentences of the article, and has no further disclosure neither in labor legislation, nor in the clarifications of higher judicial instances. This paper examines the trends in law enforcement practice and its possible problems by analyzing the practice of Russian courts for the period from 2012 to 2021. This analysis has highlighted a number of enforcement problems: the courts do not distinguish between the principle of respect for the dignity of an employee and the principle of prohibition of discrimination in the sphere of work; there is a formal court approach to considering allegations of psychological harassment and pressure in the workplace; courts apply general rules on the distribution of the burden of proof in cases of psychological harassment.
Central nervous system syndrome associated with Marek’s disease in Hubbard broilers
Authors: Haems K. , Van Brantegem L. , Van Erum J. , Garmyn A.
Published: February 2023

Marek’s disease (MD) has a high economic impact in poultry production worldwide. MD consists of several pathologic syndromes of which the most commonly encountered are lymphoproliferative syndromes such as acute MD. Sporadically, MD leads to central nervous system syndromes characterized by non-neoplastic brain pathology. In this case report, an onset of neurological signs on two different broiler farms, housing ‘slow-growing’ Hubbard JA 757 broilers, is described. On the first farm, clinical signs were observed from 42 days of age onwards and on the second farm, respectively from 42 (stable 1) and 30 days (stable 2) of age onwards. The neurological symptoms consisted of acute central nervous system signs, which started with flaccid neck paralysis. Histopathological examination revealed multifocal perivascular cuffing of CD3 positive mononuclear cells in the brain tissues. These findings pointed towards the development of transient paralysis. qPCR analysis confirmed the diagnosis. In broiler flocks, which only have a limited life span, vaccination is not common practice. In flocks of slow-growing breeds, outbreaks of MD might become more important again. Therefore, vaccination of slow-growing broilers against MD seems recommended.