bluuebunny/crossref_metadata_2025 huggingface dataset:
PURO SANGUE DE CORRIDA: REVISÃO DE LITERATURA
Authors: Leão Lisa Marie Paiva , Saraiva Mariana da Silva , Silva Matheus Marques da , Santos Milena Carnot Madeira , Alves Mônica Soares , Santos Monique Jesus dos , Poncio Alana Camargo
Published: September 2024

O presente estudo tem por finalidade apresentar os principais parâmetros genéticos e não - genéticos para as características de desempenho e habilidades dos equinos da raça Puro Sangue Inglês. Algumas delas se destacando por diversas aptidões, sendo: trabalho, lazer, pelagem exótica e esportiva e sua principal utilização devido à sua grande capacidade de velocidade e resistência em competições como o turfe e o hipismo. Descrevendo o desenvolvimento da raça com o intuito de criar um cavalo esportivo mais veloz e forte, com base no cruzamento genético de outras raças de corridas. Como fontes de variações estudadas, consideraram-se os fatores não-genéticos, sendo: o histórico e sua origem, as características e morfologia, as práticas de manejo reprodutivo, alimentar e sanitário, as particularidades da raça, o impacto econômico e as alterações músculo -esqueléticas e respiratórias. O objetivo deste trabalho é abordar os principais achados sobre determinados conhecimentos sobre a raça Puro Sangue Inglês, a fim de promover uma revisão completa sobre estes animais.
DIAGNÓSTICO E TRATAMENTO DAS LESÕES FIBRO-ÓSSEAS DOS MAXILARES: REVISÃO INTEGRATIVA
Authors: Silva Mariana Roberta Santos , Espíndola Júnior Helber Bezerra , Guimarães Lucas de Melo , Souza Pedro Henrique Pereira de , Ataíde Juliana Perez Leyva , Aragão Tiago Viana de Siqueira , Anjos Clara Beatriz Silva dos , Wanderley Pietra Garrido Costa , Silva João Victor Espíndola
Published: September 2024

Introdução: A lesão fibro-óssea não constitui um diagnóstico específico, mas sim um processo. Elas são classificadas como um grupo de distúrbios da face e da mandíbula, caracterizadas por uma substituição progressiva e variada do osso normal por tecido fibroso contendo material mineralizado neoformado. Destaca-se a relevância de mais estudos acerca das lesões fibro-ósseas dos maxilares, já que é um grupo de distúrbios raros e com diversas formas de apresentação. Objetivo: Analisar e compreender as diferentes formas existentes de diagnóstico, bem como os métodos mais eficazes de tratamento disponíveis para as lesões fibro-ósseas. Metodologia: Foram selecionados artigos científicos em inglês, espanhol ou português, publicados entre 2013 e 2022. Através das plataformas digitais MEDLINE via PubMed, Biblioteca Virtual de Saúde e Scopus via Portal Capes, por contarem com a maior parte das publicações na área da saúde. Resultados e discussão: Da análise realizada, 56 artigos foram encontrados e a amostra final foi composta por 34 artigos. As lesões aparecem como áreas mistas radiolúcidas e radiopacas. A displasia fibrosa é a lesão fibro-óssea mais comum dos maxilares, seguida pelo fibroma ossificante e displasia óssea, com o fibroma ossificante trabecular juvenil sendo raro. Os tratamentos variam de excisão cirúrgica completa a raspagem e recontorno. Conclusão: Um diagnóstico preciso e multidisciplinar é essencial para o tratamento adequado e bom prognóstico. O manejo visa minimizar complicações, com a cirurgia indicada em casos sintomáticos. As lesões têm características e tratamentos específicos. O diagnóstico e o tratamento das lesões fibro-ósseas dos maxilares necessitam de uma avaliação clínica, radiográfica, principalmente a tomografia computadorizada de feixe cônico devido sua alta resolução e menor dose de radiação, e a histopatológica, quando achados clínicos e radiológicos não são conclusivos.
La iniciativa Yasuní-ITT: Del sueño de la moratoria petrolera a la pesadilla de los derechos colectivos
Authors: González Javier Dávalos , Martins Samuel Silveira
Published: September 2024

La iniciativa Yasuní-ITT surgió en el marco de la lucha contra el cambio climático global. Los objetivos de este proyecto fueron conservar la biodiversidad del Parque Nacional Yasuní y preservar la vida de los pueblos no contactados de la Amazonía ecuatoriana, así como desarrollar energías limpias y promover el desarrollo social de esta zona del país. Desde una perspectiva socio-jurídica, este artículo analiza el rol desempeñado por el Estado, las comunidades indígenas y la sociedad civil en lo relativo a los estándares internacionales de los derechos de participación y los derechos de los pueblos indígenas, en particular de la consulta previa, libre e informada. La lucha por la participación en la toma de decisiones sobre este proyecto refleja los importantes retos en la construcción de políticas nacionales y globales en materia socio-ambiental.
Analysis of the effectiveness of equations for calculating pulmonary mechanical power: Integrative review
Authors: Abreu Ludmilla Pinto Guiotti Cintra , Abreu Ronaldo Gonçalves , Luz Glécia Virgolino da Silva
Published: September 2024

Pulmonary mechanical power (MP) was interpreted as the force applied by the ventilator to displace a volume of air within the lungs, deforming the epithelium and cellular endothelium, per unit of time, expressed dimensionally in Joules per second (J/s) or Joules per minute (J/min). This applied force generates energy, and the degree of energy transfer can lead to direct damage to the alveolar capillary membrane and mechanotransduction, which is the conversion of a mechanical stimulus into biochemical and molecular signals; in addition to being dependent on the ventilatory parameters adjusted at the bedside. MP is important because it is a ventilator parameter that has been associated with mortality. Therefore, the objective of this review is to analyze the effectiveness of the equations for calculating pulmonary mechanical power. This is a comprehensive integrative review, with searches in the following databases: BVS (BIREME), BVS (LILACS), CINAHL (EBSCO), Cochrane Library, Embase, IEEEXplore, PEDro, PubMed/MEDLINE, SciELO, ScienceDirect, Scopus, and Web of Science (Clarivate Analytics). Eight eligible articles were found that proposed MP calculations. It was observed that studies on this topic began in 2016 with an equation proposed by Gattinoni, with the number of studies being relatively small, although MP is a variable associated with mortality. Six distinct equations were identified, three used in controlled volume and three in controlled pressure. It can be concluded that the calculation of MP is important for lung protection, can be used at the bedside without interruption of ventilation, and should be part of clinical practice. Finally, the simplified equations are more practical to apply and are highly accurate when compared to the gold standard of measurement.
Benefits of using a theatrical play to promote knowledge about Health and Environmental Awareness in the Rocinha Favela
Authors: Alves Mariana Pace , dos Santos Talita Suelen Carvalho
Published: September 2024

Enabling access to knowledge means promoting equality for all individuals. Creating strategies to address issues related to health and the environment is a necessity to achieve the sustainable development goals that are fundamental to human well-being, equity, social justice, and improving quality of life. The objective of this study was to verify the benefits of using a play, entitled Na Trilha do Autocuidado, structured and presented to one hundred residents of the Rocinha favela/RJ. It is the report of an experience in August 2024. The play took place at the Rocinha Park Library, lasting twenty minutes, followed by a conversation circle with the audience. The play was written by a health professional and produced by the Sociocultural Association Semearte, which aims to contribute to the human and artistic development of children, adolescents, and young people in situations of social risk through culture. The results, recorded through empirical observations and written and verbal reports after the play, demonstrated greater knowledge about topics related to health and the environment, such as: doing more physical activity, eating healthily, avoiding smoking, developing self-knowledge and taking better care of the environment. We believe that the content transmitted through the play and the discussion group promotes positive changes in the way individuals take care of themselves, adopting an active role, taking control of their health and adopting attitudes that preserve the environment. When individuals identify healthy and sustainable behaviors and begin to demonstrate them, they also impact their surroundings and become multipliers of the information they have learned.
Personalization of NSAID prescription in Dentistry: Patient safety
Authors: Costa William Filipin , de Arruda Matheus Henrique Beltrame , Iwaki Fernanda Vessoni , Lança Henrique Fuzeti , Pavan Nair Narumi Orita
Published: September 2024

In dentistry, the management of inflammation following dental procedures primarily involves NSAIDs, such as ibuprofen and diclofenac, but it is crucial to consider comorbidities such as hypertension and diabetes when prescribing these medications. Paracetamol is preferred in cases where NSAIDs are contraindicated, especially in pregnant women, and personalized treatment is essential to ensure safety and efficacy.
Approach to hypodermoclysis in geriatric palliative care
Authors: dos Santos Cristiele Rodrigues , Honório Gizele Soares Marques , Camargos Izabella Coelho Ribeiro , Cardoso Ludmila Melo , de Souza Marilza Alves
Published: September 2024

This study consists of an integrative review on the use of hypodermoclysis in palliative care for elderly patients, focusing on geriatric nursing practice. Objective: Aspects such as puncture sites, device fixation techniques, management and post-insertion care of the catheter were discussed. Method: Methodological steps were used and articles published between 2014 and 2024 in the MEDLINE, LILACS and BDENF databases were selected. Results: The results highlighted hypodermoclysis as a safe and effective technique for the administration of medications and fluids, especially in patients with swallowing difficulties or compromised venous access. Final considerations: Hypodermoclysis is a safe and effective technique for administering medications in elderly patients, especially in palliative care. It is practical, less invasive and offers greater comfort, promoting treatment adherence and patient satisfaction. The study reviewed its advantages and applications, highlighting it as a viable alternative to intravenous administration, especially in elderly patients. However, it identified gaps in knowledge that indicate the need for further research, especially to develop protocols that allow greater autonomy for nursing.
Desafios e estratégias no manejo cirúrgico de emergências em câncer colorretal: Uma revisão sistematica
Authors: Oliveira Carlos Walmyr de Mattos , Silva Luís Carlos de Paula e , Dias Gabriel Calegari , Guimarães Edilson Misael , Valentim Laenne Ágata , Lins Washington Wallace Souza , de Magalhães Daniel Costa , Campos Antônio Lopes , Gonçalves Rodrigo Vitorino , Dias Ana Laura Matos Moreira , Silva Rafael Carvalho de Oliveira , Silva Karina Mitsuzumi Ono
Published: September 2024

O manejo cirúrgico das emergências associadas ao câncer colorretal é complexo e desafiador, afetando até um terço dos pacientes com essa condição. Complicações como obstrução intestinal, perfuração e sangramento são comuns e frequentemente envolvem estadiamento avançado e características desfavoráveis do tumor, o que pode elevar a morbidade e a mortalidade. Este artigo revisa a literatura sobre estratégias cirúrgicas para essas emergências, analisando estudos publicados entre 2000 e 2024. A obstrução intestinal, que pode ocorrer em até 29% dos pacientes, exige decisões rápidas, com abordagens variando conforme a localização: obstruções proximais à flexura esplênica geralmente são tratadas com ressecção ileocólica direita e anastomose, enquanto obstruções distais podem requerer colostomia em alça ou ressecação de Hartmann. A perfuração e o sangramento gastrointestinal são críticos e demandam cirurgia urgente para evitar complicações graves, como peritonite e choque séptico. A tomografia computadorizada (TC) desempenha um papel crucial no planejamento cirúrgico devido à sua alta sensibilidade e especificidade. A laparoscopia, embora ainda menos utilizada em situações emergenciais, apresenta vantagens em termos de menor perda sanguínea e recuperação mais rápida em comparação com a cirurgia aberta. No entanto, sua eficácia em emergências requer mais validação. A abordagem cirúrgica deve ser personalizada, levando em consideração a localização do tumor, o estado clínico do paciente e os recursos disponíveis para otimizar os resultados clínicos e oncológicos.
Risk perception and tolerance of family farming managers
Authors: Duarte Daura Helena Jales Dantas , Morais Eulita de Souza , Siqueira Elisabete Stradiotto , Nobre Fábio Chaves , Nobre Liana Holanda Nepomuceno
Published: September 2024

Objective: to analyze the relationships between the constructs of perception and tolerance, perceived by rural property managers. Theoretical framework: based on literature through family farming and tolerance to risk and uncertainty in agriculture. Method: A survey was conducted with 137 farmers. This is a quantitative study of a descriptive nature. Data were collected through a questionnaire and reveal that the behavior of the interviewees is restricted to actions that do not place them in situations of financial risk. Results and conclusion: In the analysis of the averages of the risk behavior factor, the results revealed that risk perception precedes risk tolerance, and the relationship between the constructs is inverse, in which managers perceive more risk in a situation in which they have a lower tendency to incur risks. In this context, the greater the perceived risk, the less likely the manager will be to carry out the business. The findings allowed for a broader understanding of the relationships between the risk constructs within the decision-making process. In general, family farming managers show signs of the need to manage finances more efficiently and in most cases seek to improve these practices. Research implications: the implications of this study for the management of family farming show that managers perceive risk situations and have a low willingness to take this risk (risk tolerance). Originality/value: broadens understanding of the tolerance to financial risk of families who live off family farming.
Abiotic factors and the growth of cyanobacteria in surface water reservoirs in the state of Pernambuco
Authors: Regis Andreia Souza , da Silva Ronaldo Faustino , de Oliveira Fabio Henrique Portella Corrêa , de Oliveira Eduardo José Alécio
Published: September 2024

Objective: Analyze the relationship between physical-chemical and climatic abiotic factors in relation to the occurrence of cyanobacteria genera in surface water reservoirs used for public supply in the state of Pernambuco. Literature Review: Information is presented on cyanobacteria and the consequences of the release of untreated effluents on the eutrophication of surface waters with effects on the growih of cyanobacteria and consequences for aquatic organisms and humans and the climate in regions of Pernambuco where water reservoirs are located, Method: Quali-quantitative descriptive and exploratory approach to the analysis of abiotic variables (pH, CE., Turbidity, Color, Calcium, Magnesium, Chlorides, Sulfate, Nitrogen, Phosphate, Alkalinity, Hardness, Iron, Manganese, Aluminum and rainfall) and biotic (Cyanobacteria density), collected from the Pernambuco Sanitation Company — COMPESA. The samples were from eutrophic freshwater reservoirs in Pernambuco collected between 2010 and 2020. Results and Discussion: The most frequent genus of cyanobacteria was Raphidiopsis/Cylindrospermopsis, found abundantly in all reservoirs, where the increase in color, turbidity and pH were positively correlated with the presence of Microcystis and Raphidiopsis/Cylindrospermopsis, and negatively with the increase in toughness. A positive correlation was also observed between hardness and the increase in Planktorhrix density. Research Implications: Generate guidelines for drinking water supply presenting tools for understanding abiotic conditions that influence the growth of cyanobacteria, in order to outline control or services, ‘mitigation strategies in ETAs. Originality/Value: Generate useful information in the evaluation of abiotic parameters and cyanobacteria density, observed over a long period (10 years), showing positive/negative correlations in surface waters used for human consumption.
Evaluating the Impact of Modern Laser Technologies on Dentistry in European Union Countries
Authors: Chertov Sergiy , Тatarina Olha , Karkimbayeva Gulshakhar , Rysbayeva Zhanagul , Dovzhuk Natela
Published: September 2024

Introduction: In dentistry, understanding laser wavelength interactions with oral tissues enhances patient management. Over two decades, lasers have been used in dental practices for diagnostics, caries detection, calculus identification, hard tissue cutting, and root canal disinfection. They reduce patient anxiety and the need for anesthesia in hard tissue applications Aim. The objective of this research is to provide a review on how European dentistry has been affected by the use of modern laser technology between 2020 and 2024. This was done by classifying the types of lasers, examining their uses in different dental treatments, investigating the problems that may arise as a result, and appraising the benefits for oral health and patient outcomes. Methods: A systematic literature review was conducted from 2020 to 2024, focusing on modern laser technologies in dentistry within European countries. Using the PRISMA flow diagram, studies were identified, screened, and included based on keywords related to dentistry and laser technologies. Initial searches identified 17,130 records, narrowed down to 27 relevant studies through various criteria. Inclusion required studies to focus on dental laser applications in specified European countries, published between 2020 and 2024, and be peer-reviewed. Results: The review covered studies from 2020 to 2024, highlighting various dental specialties and laser technologies like Erbium, CO2, Diode, Nd, Excimer, and Fiber lasers. Findings indicated lasers improved precision, reduced discomfort, and enhanced patient outcomes with minimal postoperative pain and faster recovery times. Noted risks included thermal damage and specific complications like bleeding and pain. Conclusions: The review highlights lasers' transformative potential in EU dental care, offering precision and improved outcomes. Future research should standardize protocols, assess long-term benefits and risks, focus on safety, and integrate patient-centered outcomes to enhance the evidence base supporting laser technologies in routine dental care.
A conceptual framework for enhancing product standardization in Nigeria’s manufacturing sector
Authors: Ifeanyi Chukwunonso Okeke  , Edith Ebele Agu  , Onyinye Gift Ejike  , Chikezie Paul-Mikki Ewim  , Mobolaji Olalekan Komolafe
Published: September 2024

The manufacturing sector in Nigeria plays a pivotal role in the nation's economic development. However, the industry faces significant challenges related to product quality and standardization. This review presents a conceptual framework designed to enhance product standardization within Nigeria’s manufacturing sector. Product standardization is critical for ensuring quality, safety, and consumer satisfaction, which in turn drives economic growth and global competitiveness. The proposed framework encompasses several key components. First, it emphasizes the importance of establishing clear standards and regulations that align with international best practices. This involves collaboration between government bodies, industry stakeholders, and standardization organizations to develop comprehensive guidelines that address various aspects of manufacturing processes. Second, the framework advocates for strengthening regulatory enforcement to ensure compliance with established standards. This includes implementing robust inspection mechanisms and penalties for non-compliance. Furthermore, the framework highlights the need for capacity building within the sector. This involves investing in training and development programs to enhance the technical skills of the workforce and improve the operational efficiency of manufacturing units. Additionally, it suggests leveraging technology and innovation to support standardization efforts. Adopting advanced manufacturing technologies and digital tools can streamline processes and improve product consistency. The framework also proposes the establishment of a national quality assurance system that integrates feedback from consumers and industry experts. This system would facilitate continuous improvement by addressing emerging challenges and incorporating new insights. Lastly, the framework calls for collaborative partnerships between public and private sectors to foster a culture of quality and standardization. By addressing these components, the framework aims to provide a comprehensive approach to enhancing product standardization in Nigeria’s manufacturing sector. This, in turn, is expected to improve product quality, boost consumer confidence, and enhance the sector's competitiveness on a global scale.
Developing a regulatory model for product quality assurance in Nigeria’s local industries
Authors: Ifeanyi Chukwunonso Okeke  , Edith Ebele Agu  , Onyinye Gift Ejike  , Chikezie Paul-Mikki Ewim  , Mobolaji Olalekan Komolafe
Published: September 2024

This paper presents a comprehensive regulatory model for enhancing product quality assurance within Nigeria's local industries. As Nigeria's industrial sector continues to expand, the need for robust quality assurance mechanisms has become increasingly critical. Current challenges include inconsistent quality standards, inadequate enforcement of regulations, and limited industry compliance, which undermine product reliability and consumer trust. This study proposes a regulatory framework designed to address these issues by integrating international best practices with localized strategies. The proposed model emphasizes three core components: regulatory standards, enforcement mechanisms, and industry collaboration. First, the model advocates for the establishment of clear, standardized quality benchmarks tailored to the unique needs of local industries. By adopting globally recognized standards and adapting them to local contexts, the model aims to enhance the consistency and reliability of products manufactured in Nigeria. Second, the model outlines a multi-tiered enforcement strategy, including regular inspections, certification processes, and penalties for non-compliance. It suggests leveraging technological advancements, such as digital tracking systems and automated quality checks, to improve monitoring efficiency and reduce the potential for corruption. Third, the model highlights the importance of fostering collaboration between regulatory bodies, industry stakeholders, and consumer organizations. By promoting dialogue and cooperation, the model seeks to create a supportive ecosystem where best practices are shared, and feedback mechanisms are established to continuously refine quality standards. The regulatory model presented herein is designed to be dynamic and adaptable, capable of evolving in response to emerging industry trends and technological advancements. It aims to not only address current quality assurance challenges but also to set a foundation for sustained industrial growth and consumer protection. By implementing this model, Nigeria's local industries can achieve higher standards of product quality, enhance consumer confidence, and contribute to the broader goal of economic development.
A policy model for regulating and standardizing financial advisory services in Nigeria’s capital markets
Authors: Ifeanyi Chukwunonso Okeke  , Edith Ebele Agu  , Onyinye Gift Ejike  , Chikezie Paul-Mikki Ewim  , Mobolaji Olalekan Komolafe
Published: September 2024

This paper presents a policy model for regulating and standardizing financial advisory services in Nigeria’s capital markets, addressing the urgent need for structured oversight to enhance market integrity and investor protection. The model proposes a comprehensive regulatory framework that integrates stringent standards for financial advisors, uniform guidelines for service delivery, and robust compliance mechanisms to ensure adherence to best practices. It emphasizes the establishment of a central regulatory body responsible for setting and enforcing standards, alongside a system of periodic audits and performance evaluations to maintain high-quality advisory services. Key components of the proposed policy include the development of a certification process for financial advisors, mandatory training programs, and the implementation of transparent disclosure requirements to aid investors in making informed decisions. The model also advocates for leveraging technological advancements, such as digital platforms for real-time monitoring and data analytics, to streamline regulatory processes and enhance transparency in financial advisory practices. The policy model aims to address existing gaps in regulatory oversight by providing clear guidelines and enforcement mechanisms to prevent conflicts of interest, ensure ethical conduct, and foster investor confidence. By aligning Nigeria’s capital markets with international best practices and integrating technological solutions, the model seeks to create a more resilient and trustworthy financial advisory environment. Expected outcomes include improved service quality, increased investor protection, and enhanced market efficiency. The model’s implementation will contribute to greater market stability and confidence, supporting sustainable growth in Nigeria’s capital markets. This approach not only addresses current regulatory challenges but also positions Nigeria as a leader in financial advisory standards within the global financial community.
A digital service standardization model for Nigeria: The role of NITDA in regulatory compliance
Authors: Mobolaji Olalekan Komolafe  , Edith Ebele Agu  , Onyinye Gift Ejike  , Chikezie Paul-Mikki Ewim  , Ifeanyi Chukwunonso Okeke
Published: September 2024

The digital transformation in Nigeria has accelerated the need for effective standards and regulations to ensure quality and interoperability of digital services. The National Information Technology Development Agency (NITDA) plays a crucial role in this context by overseeing regulatory compliance and fostering a conducive environment for digital innovation. This review presents a comprehensive model for digital service standardization tailored to Nigeria's unique socio-economic and technological landscape. The proposed model emphasizes the importance of regulatory frameworks established by NITDA in promoting consistency, reliability, and security across various digital platforms and services. The model outlines key components necessary for effective standardization, including policy formulation, compliance monitoring, and stakeholder engagement. It integrates best practices from international standards while adapting them to local needs and challenges. Central to the model is the role of NITDA in developing and enforcing standards that align with global benchmarks, thereby ensuring that Nigerian digital services are competitive and secure. A significant aspect of the model is its focus on regulatory compliance, which is vital for maintaining the integrity of digital services and protecting user data. The review discusses how NITDA's regulatory initiatives address common issues such as data privacy, cybersecurity, and service quality. By examining case studies and industry feedback, the review highlights the impact of NITDA's efforts on improving the overall digital service ecosystem in Nigeria. The model also addresses the need for continuous evaluation and adaptation of standards in response to technological advancements and emerging threats. It proposes mechanisms for regular updates and revisions to standards, ensuring that they remain relevant and effective. Additionally, the review explores the role of collaborative partnerships between NITDA, industry stakeholders, and academic institutions in advancing digital service standardization. The proposed digital service standardization model provides a structured approach to enhancing regulatory compliance and fostering a robust digital environment in Nigeria. It underscores the pivotal role of NITDA in driving these efforts and offers a framework for ongoing improvement and adaptation to the dynamic digital landscape.
Historia del Teatro y el Cine en Huelva : Cien años del Gran Teatro (1923-2023)
Authors: Sugrañes Andivia Jesús E.
Published: September 2024

X Premio de Estudios Onubenses, 2013. Historia del teatro y el cine en Huelva, es una investigación cuyo objetivo ha sido contar la bella relación los onubenses con las representaciones teatrales y posteriormente, con la industria del celuloide. Realizando un itinerario desde el siglo XVI hasta la actualidad, trazaremos un camino en el que recorremos la evolución urbanística de la ciudad, las reivindicaciones sociales a través de la prensa y la figura de ilustres onubenses que fueron artífices de que la ciudad, otorgara a los ciudadanos espacios donde disfrutar de este gran arte. Teatros como el Colón, el Mora o el Real Teatro, serán algunos de los grandes templos de Talía de los que hablaremos. También se encontrarán en las páginas de este trabajo las distintas salas de cines y la evolución de estas, desde pequeños cines de verano en las calles hasta llegar a las salas multicines actuales. Finalmente, haremos un especial hincapié, en el único teatro que ha sobrevivido hasta nuestros días, en el año de su centenario: El Gran Teatro.
Passiflora edulis Sims leaves ameliorate inflammation and prevent cartilage degradation in osteoarthritic rats by suppressing cytokines, nitric oxide, and matrix metalloproteinase-9
Authors: Sandhiutami Ni Made Dwi , Desmiaty Yesi , Fahleni Fahleni , Muslimawati Ravina , Sari Fania
Published: September 2024

Context: Treatment for osteoarthritis focuses on controlling pain, lowering inflammation, delaying cartilage deterioration, and minimizing impairment. Aims: To evaluate the bioactivity of leaf extract 'markisa' (Passiflora edulis, MLE) as an in vitro radical scavenger, and an in vivo edema reducer and pro-inflammatory mediators in an osteoarthritis rat model. Methods: MLE was prepared by an ultrasonication method with ethanol. First, the in vitro antioxidant activity of MLE was assessed with ABTS reagent, and the total phenolics (TPC) and flavonoid (TFC) contents were determined. Furthermore, in vivo tests were conducted. Wistar rats were induced osteoarthritis by intraarticular injections of sodium iodoacetate (13.5 mg/kg BW) and observed for one month. MLE was administered orally to animal models in doses of 100, 200, and 400 mg/kg BW every day for two weeks. Body weight and knee edema enlargement were observed every week. At week 6th, all animals were sacrificed for evaluation of spleen weight, hematology analysis (leukocyte and lymphocyte number), and pro-inflammatory mediators assay (NO, IL-6, TNF-α, and MMP-9). Results: This study showed that MLE has antioxidant capacity 13.26 ± 0.7 mol TE/g, TPC 8.17 ± 0.03 mg GAE/g, and TFC 3.28 ± 0.3 mg QE/g. In vivo tests showed that MLE-treated rats had reduced knee edema, hematological improvement (decreased NO, IL-6, and TNF-α), spleen enlargement, and protection against cartilage degradation by decreasing MMP-9. Conclusions: These findings suggest that MLE therapy has the potential to restore the state of osteoarthritic rats to normal, with varying degrees of dose-dependent improvement.
Bioinformatic investigation of Lytechinus variegatus coelomic fluid peptides as multiple oncogenic proteins inhibitors of colorectal cancer
Authors: Rita Rauza S. , Cuandra Kevin N. , Khairani Salsabila P. , Putera Rizky E. , Amalia Vella , Shofiy Alifya R. , Wahyudi Dhyani P. , Yustian Ahmad R. , Nabila Dinda P. , Maharani Malya C. S. , Kahar Andi A. D.
Published: September 2024

Context: Colorectal cancer (CRC) remains a significant global health challenge despite advances in treatment modalities. The coelomic fluid of Lytechinus variegatus emerges as a rich source of bioactive peptides with the potential as a new therapeutic anticancer agent. Aims: To analyze the toxicity, allergenicity, and potential of L. variegatus coelomic fluid peptides as multitarget inhibitor agents of CRC cancer cells through an in silico study. Methods: Ten peptides from L. variegatus coelomic fluid were processed using UCSF Chimera software to model the three-dimensional structure. ToxinPred and AllerTop web servers were used to analyze the toxicity and allergenicity of peptides, respectively. The 3D structures of EGFR, AKT1, GSK3B, VEGFR2, and JAK3 were retrieved from the PDBJ database. MOE Software was used to perform molecular docking. Results: Peptide 4 binds to the ATP binding pocket of GSK3B protein with the strongest binding affinity value (-8,68 kcal/mol). The docking results between EGFR and peptides showed that peptide 10 binds to the ATP binding pocket with the lowest binding affinity (-9.52 kcal/mol). Peptide 2 binds to the ATP binding pocket of AKT1 with the lowest binding affinity value (-9.16 kcal/mol). Peptide 3 has the lowest binding affinity value of the JAK3 ATP binding pocket (-8,67 kcal/mol). Peptide 7 binds to the ATP binding pocket of VEGFR2 with the strongest binding affinity (-9,67 kcal/mol). Conclusions: The L. variegatus peptides have the potential as multitarget anti-CRC agents by inhibiting the activity of GSK3B, EGFR, AKT1, JAK3, and VEGFR2 proteins through the ATP competitive inhibitor action based on in silico study.
Exploring Biosurfactants: Sustainable Solutions for Overcoming Antimicrobial Resistance and Drug Adverse Effects
Authors: Sivakumar K.K. , Najmusaqib Syed , Magrey Ashiq Hussain , Senthil A. , Fatma Sabeen , Majumder Jayeeta , Gangopadhyay Sourav , Biswas Susmi
Published: September 2024

Antimicrobial resistance (AMR) poses a significant global health threat, necessitating the exploration of alternative strategies to combat microbial pathogens. Biosurfactants, natural compounds produced by microorganisms, have emerged as promising candidates due to their diverse biological activities and sustainable properties. This review aims to provide a comprehensive overview of biosurfactants' potential as sustainable solutions for overcoming AMR and mitigating drug adverse effects. We discuss the mechanisms of action of biosurfactants against microbial pathogens, highlighting their ability to disrupt cell membranes, inhibit biofilm formation, and modulate immune responses. Furthermore, we explore the biocompatibility and eco-friendly nature of biosurfactants, underscoring their advantages over synthetic drugs. However, challenges such as limited scalability and variability in production hinder their widespread adoption in pharmaceutical applications. We propose interdisciplinary research efforts to address these challenges and optimize the use of biosurfactants in combating AMR and minimizing drug adverse effects. Through collaborative initiatives and innovative approaches, biosurfactants hold immense promise as sustainable alternatives to conventional antimicrobial agents, paving the way for a healthier and more resilient future.
Aspirin Versus Enoxaparin for Deep Vein Thrombosis Prevention After Orthopedic Surgery: A Review of Efficacy and Safety
Authors: Sayed A Mahmud  , Anura Manandhar  , Ghadeer Sabir  , Hala Abdeldady  , Adoum Oumar Abakar  , Ravindra Reddy Gangavarapu  , Iana Malasevskaia
Published: September 2024

Deep vein thrombosis (DVT) is a significant complication following orthopedic surgery. This review evaluates the comparative efficacy and safety of aspirin and enoxaparin for DVT prophylaxis in this patient population. A comprehensive literature search identified relevant randomized controlled trials (RCTs), retrospective studies, and systematic reviews with meta-analyses comparing these two medications. The findings regarding aspirin's efficacy compared to enoxaparin are mixed. While some studies suggest comparable effectiveness in preventing DVT, others indicate a potential advantage for enoxaparin. However, aspirin offers advantages in terms of ease of administration (oral medication), potentially lower bleeding risk, and potentially improved patient satisfaction and adherence. Drawing definitive conclusions is limited by heterogeneity among the included studies. Variations in patient populations, surgical procedures, and follow-up durations hinder a more conclusive comparison. Additionally, the potential for bias in some studies necessitates a cautious interpretation of the results. This review also has limitations, as it does not explicitly appraise the methodological quality of each included study. Despite these limitations, aspirin emerges as a potentially viable alternative, and perhaps even an excellent option, for DVT prophylaxis after orthopedic surgery in specific scenarios. However, limitations within the current evidence necessitate further research with standardized protocols and rigorous methodological evaluation. Individualized approaches that consider patient-specific risk factors and surgical procedures are crucial. If future research confirms aspirin's efficacy and safety profile, its ease of use and potential benefits could lead to it becoming a preferred option for DVT prophylaxis.
Backyard Buoys: Meeting Needs of Coastal, Indigenous Communities Through Co-Design and Co-Production
Authors:   University of Washington, Northwest Association of Networked Ocean Observing Systems, Newton Jan , Wisdom Sheyna , Iwamoto Melissa , Carini Roxanne , Watson Jordan , Boulay Sebastien , Mactavish Duncan , Hagen Jennifer , Schumacker Joe , Rudolph Dua , deBrum-Kattil Dolores , Tuaua Pua , Brown Eric , Burch Scott , Hopson Jr. John , Evans Jenny
Published: September 2024

The Backyard Buoys project (https://backyardbuoys.org/) enables Indigenous and coastal communities to gather and use wave data to enhance their blue economies and hazard protections. These communities have been historically underserved, and climate change is making weather and wave predictability even harder. Leveraging low-cost, scalable marine technology in partnership with regional ocean observing networks, Backyard Buoys offers a system for community-managed ocean buoys and data access to complement Indigenous Knowledge. These innovations include a sustainable process for community-led implementation and stewardship of affordable ocean buoys along with co-designed and co-produced mobile and web-based applications (apps) that render data easy to access and understand.
Soledad conyugal de una mujer mayor mexicana: aproximación desde la teoría fundamentada
Authors: Serrano Ceña Alba , González Tovar José , Monroy Velasco Iris Rubí
Published: September 2024

El siguiente estudio de caso de una mujer adulta mayor mexicana con sentimientos de soledad tiene como objetivo explorar las experiencias de vida que propiciaron este sentimiento, las estrategias de manejo y/o disminución y, los efectos sobre su salud. Se utiliza el método biográfico narrativo, ubicado dentro de la investigación cualitativa, a través de una entrevista semiestructurada en profundidad que mediante la narración de experiencias, ideas y aprendizajes se extrae el objeto de estudio. Los resultados muestran cómo nace este sentimiento por la falta de apoyo familiar en la infancia, manteniéndose en la relación conyugal. El afrontamiento con actividades laborales, sociales y familiares repercuten positivamente, mientras que la última junto con la falta de apoyo impactan sobre su salud física.
The Impact of Trade Policies on International Marketing Strategies
Authors: Owusu Samuel Ening , Peyravi Bahman
Published: September 2024

This study explores the dynamic interplay between trade rules and worldwide marketing tactics, with the goal of elucidating the varied influence of global economic regulations on multinational firms. The research takes a mixed-methods approach, focusing on various industries and geographical locations and includes qualitative studies of trade regulations as well as quantitative assessments of their consequences for marketing tactics. The extensive literature analysis establishes a theoretical framework by investigating how tariff reductions, non-tariff obstacles, and free trade agreements affect market entrance tactics, supply chain resilience, and digital marketing adaptations. The study investigates the changing character of trade policies, recognizing their temporal and spatial dynamics, and evaluating their impact on enterprises of various sizes. The study design is guided by ethical concerns, which ensure the confidentiality of sensitive information and obtaining participants' informed consent. The research intends to provide significant insights on the flexibility of worldwide marketing strategies in the face of changing trade environments by admitting potential limits and offering a comprehensive schedule and budget. The intended outcomes include contributions to academic knowledge and practical applications that will assist firms, governments, and stakeholders in managing the difficulties of the worldwide economy. In all, this study adds to the current discussion about the junction of trade policy and international marketing, encouraging a better knowledge of the difficulties and possibilities in today's linked and ever-changing global economy. ‍
The Impact of Trade Policies on International Marketing Strategies
Authors: Sargsyan Anzhela , Peyravi Bahman
Published: September 2024

We discuss the opportunities and challenges that are faced when businesses consider expanding into Armenia. Armenia has experienced multiple economic growths, exceeding 12% in 2022 and solidifying its position as the fastest growing economy among former Soviet countries. However, despite the economic boom, businesses venturing into Armenia encounter a complex regulatory environment with a growing tech industry, lack of government bureaucracy, limited market size, limited trading process, as well as corruption remains an issue. Armenia's successful companies like PicsArt, Krisp and Softconstruct are the future growth for Armenian Tech, as they help foreign investors to see the positive image and will help to operate its expansions in the Armenian market and globally. Coca- Cola HBC Armenia's aim is to become a leading beverage partner for every consumer. Therefore, Coca-Cola HBC Armenia's strategies were to have anti-bribery training and foster partnerships to promote and navigate foreign markets in Armenia. The study needs more research on business expansion in Armenia, as the study had limitations. Overall, Armenia presents opportunities and challenges expanding into the Armenian market. Armenia's economy will grow much harder and more successful. ‍
Block Programming vs Codding: The Benefits and Drawbacks
Authors: Igumenov Aleksandr , Marinuškinas Jevgenijus
Published: September 2024

The demand for creating diverse programs is increasingly prominent in the computer market and the flourishing realm of mobile devices. Furthermore, mobile phones have become essential work tools and are extensively used in various activities, including work, entertainment, education, IoT. Consequently, there is a growing need for modern, versatile, and efficient tools to facilitate the creation of such programs. Presently, this issue is particularly relevant as the development of these programs primarily relies on programmers with specialized education and experience who possess the requisite skills to work with specific tools. The scarcity of such skilled professionals in the labour market compounds the problem, making it expensive, challenging, or nearly impossible to hire them. One possible solution to fix this situation is the adoption of alternative application development software that do not demand extensive programming knowledge, such as visual programming software. This software has the potential for a new breed of programmers who do not have knowledge in low-level programming languages. This article aims to provide a systematic review of evaluation of the possibilities of visual and traditional programming environment software for learning and development purposes.
IMPACT OF CORPORATE GOVERNANCE ON INTELLECTUAL CAPITAL EFFCIENCY - EVIDENCE FROM SRI LANKAN BANKING SECTOR
Authors: Weerasinghe  , Thilakasiri
Published: September 2024

The study explores the intricate link between Corporate Governance (CG) factors and Intellectual Capital (IC) efficiency within the Sri Lankan banking sector. It delves into the impact of variables such as Board Size (BSIZE), Board Activity (BACT), Board Independence Composition (BIND), Audit Committee Size (AUDS), and Frequency of Audit Committee Meeting (AUDM) on Intellectual Capital, treating the latter as the dependent variable. For the five years between 2018 and 2022, the research technique comprises a thorough investigation of banking sector company in Sri Lanka, excluding three banks. The goal of the study is to obtain understanding of the connection between CG variables and IC efficiency through secondary data analysis using data from stock market transactions and audited financial statements.
The main analytical tools are descriptive statistics and regression modeling, which enable a detailed comprehension of the relationship between CG dynamics and IC efficiency. Through a detailed examination of these variables across time and across different financial institutions, the study seeks to illuminate the ways in which CG practices impact the creation and application of IC in the banking industry. In the conclusion, the results of this study are important not only for scholars but also for professionals and decision-makers in the banking sector in Sri Lanka. The study provides significant insights that can guide strategic decision-making, governance reforms, and resource allocation within banking institutions, ultimately leading to improved organizational efficiency and long-term sustainability. This is achieved by revealing the complex relationships between Corporate Governance and Intellectual Capital.