bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a theory-informed questionnaire to assess the acceptability of healthcare interventions
Authors: Sekhon Mandeep , Cartwright Martin , Francis Jill J.
Published: March 2022

Background

The theoretical framework of acceptability (TFA) was developed in response to recommendations that acceptability should be assessed in the design, evaluation and implementation phases of healthcare interventions. The TFA consists of seven component constructs (affective attitude, burden, ethicality, intervention coherence, opportunity costs, perceived effectiveness, and self-efficacy) that can help to identify characteristics of interventions that may be improved. The aim of this study was to develop a generic TFA questionnaire that can be adapted to assess acceptability of any healthcare intervention.

Methods

Two intervention-specific acceptability questionnaires based on the TFA were developed using a 5-step pre-validation method for developing patient-reported outcome instruments: 1) item generation; 2) item de-duplication; 3) item reduction and creation; 4) assessment of discriminant content validity against a pre-specified framework (TFA); 5) feedback from key stakeholders.

Next, a generic TFA-based questionnaire was developed and applied to assess prospective and retrospective acceptability of the COVID-19 vaccine. A think-aloud method was employed with two samples: 10 participants who self-reported intention to have the COVID-19 vaccine, and 10 participants who self-reported receiving a first dose of the vaccine.

Results

1) The item pool contained 138 items, identified from primary papers included in an overview of reviews. 2) There were no duplicate items. 3) 107 items were discarded; 35 new items were created to maximise coverage of the seven TFA constructs. 4) 33 items met criteria for discriminant content validity and were reduced to two intervention-specific acceptability questionnaires, each with eight items. 5) Feedback from key stakeholders resulted in refinement of item wording, which was then adapted to develop a generic TFA-based questionnaire.

For prospective and retrospective versions of the questionnaire, no participants identified problems with understanding and answering items reflecting four TFA constructs: affective attitude, burden, perceived effectiveness, opportunity costs. Some participants encountered problems with items reflecting three constructs: ethicality, intervention coherence, self-efficacy.

Conclusions

A generic questionnaire for assessing intervention acceptability from the perspectives of intervention recipients was developed using methods for creating participant-reported outcome measures, informed by theory, previous research, and stakeholder input. The questionnaire provides researchers with an adaptable tool to measure acceptability across a range of healthcare interventions.
Effective anti-mycobacterial treatment for BCG disease in patients with Mendelian Susceptibility to Mycobacterial Disease (MSMD): a case series
Authors: Mahdaviani Seyed Alireza , Fallahi Mazdak , Jamee Mahnaz , Marjani Majid , Tabarsi Payam , Moniri Afshin , Farnia Parisa , Daneshmandi Zahra , Parvaneh Nima , Casanova Jean-Laurent , Bustamante Jacinta , Mansouri Davood , Velayati Ali Akbar
Published: March 2022

Background

Post-vaccination BCG disease typically attests to underlying inborn errors of immunity (IEIs), with the highest rates of complications in patients with Mendelian susceptibility to mycobacterial disease (MSMD). However, therapeutic protocols for the management of BCG-osis (disseminated) and persistent BCG-itis (localized) are still controversial.

Methods

Twenty-four Iranian patients with MSMD (BCG-osis or BCG-itis), followed from 2009 to 2020 in Tehran, were included in the study. Their medical records were retrospectively reviewed for demographics, clinical features, laboratory findings, and molecular diagnosis. The therapeutic protocol sheets were prepared to contain the types and duration of anti-mycobacterial agents.

Results

BCG disease either as BCG-itis (33.3%) or BCG-osis (66.7%) was confirmed in all patients by positive gastric washing test (54.2%), microbial smear and culture (58.3%), or purified protein derivative (PPD) test (4.2%). The duration between BCG-osis onset and MSMD diagnosis was 21.6 months.

All except three patients were initiated on second-line anti-mycobacterial agents with either a fluoroquinolone (levofloxacin: 15 mg/kg/day, ciprofloxacin: 20 mg/kg/day, ofloxacin: 15 mg/kg/day), aminoglycoside (amikacin: 10–15 mg/kg/day, streptomycin: 15 mg/kg/day), and/or macrolide (clarithromycin: 15 mg/kg/day) along with oral rifampin (10 mg/kg/day), isoniazid (15 mg/kg/day), and ethambutol (20 mg/kg/day). Three patients showed a clinical response to rifampin, despite in vitro resistance. Fourteen (58.3%) patients received also adjuvant subcutaneous IFN-γ therapy, 50 µ/m2 every other day. At the end of survey, most patients (n = 22, 91.7%) were alive and two patients died following BCG-osis and respiratory failure.

Conclusions

We recommend the early instigation of second-line anti-mycobacterial agents in MSMD patients with BCG disease.
Novel bone morphogenetic protein 15 (BMP15) gene variants implicated in premature ovarian insufficiency
Authors: Afkhami Fatemeh , Shahbazi Shirin , Farzadi Laya , Danaei Shahla
Published: March 2022

Background

Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene mutations lead to imperfect protein function and premature ovarian insufficiency. Here we investigated the BMP15 gene variants in a population of Iranian women with premature ovarian insufficiency. We conducted predictive bioinformatics analysis to further study the outcomes of BMP15 gene alterations.

Methods

Twenty-four well-diagnosed premature ovarian insufficiency cases with normal karyotype participated in this study. The entire coding sequence and exon-intron junctions of the BMP15 gene were analyzed by direct sequencing. In-silico analysis was applied using various pipelines integrated into the Ensembl Variant Effect Predictor online tool. The clinical interpretation was performed based on the approved guidelines.

Results

By gene screening of BMP15, we discovered p.N103K, p.A180T, and p.M184T heterozygous variants in 3 unrelated patients. The p.N103K and p.M184T were not annotated on gnomAD, 1000 Genome and/or dbSNP. These mutations were not identified in 800 Iranians whole-exome sequencing that is recorded on Iranom database. We identified the p.N103K variant in a patient with secondary amenorrhea at the age of 17, elevated FSH and atrophic ovaries. The p.M184T was detected in a sporadic case with atrophic ovaries and very high FSH who developed secondary amenorrhea at the age of 31.

Conclusions

Here we newly identified p.N103K and p.M184T mutation in the BMP15 gene associated with idiopathic premature ovarian insufficiency. Both mutations have occurred in the prodomain region of protein. Despite prodomain cleavage through dimerization, it is actively involved in the mature protein function. Further studies elucidating the roles of prodomain would lead to a better understanding of the disease pathogenesis.
Individuals who report having benefitted from dialectical behaviour therapy (DBT): a qualitative exploration of processes and experiences at long-term follow-up
Authors: Gillespie Conall , Murphy Mike , Kells Mary , Flynn Daniel
Published: March 2022

Background

Qualitative research in the area of DBT is limited, particularly at follow-up. The current study explored the follow-up experiences of individuals who previously received a diagnosis of borderline personality disorder and self-report having benefitted from DBT at the time of treatment.

Methods

Individuals who completed 12 months of standard DBT and were a minimum of two years post-completion were recruited. Individual semi-structured interviews were completed with a total of twelve participants.

Results

A thematic analysis generated three main themes which indicated that participants found DBT had a positive impact on their lives in the years after the programme and enabled further development; gave them control over their lives and the ability to manage setbacks and difficult situations; and contributed to healthier and more meaningful relationships with others.

Conclusions

The findings of this study indicated that DBT contributed positively to the participants’ lives and helped advance their recovery in the years after the programme.

Despite the positive impact of DBT, participants required further support in the years following the intervention. Clinical and research implications of these findings are discussed.
Seismic Soundoff: Persuading the decision makers
Authors: Geary Andrew
Published: March 2022

In this episode, Laura Bandura discusses her 2022 Distinguished Lecture, “Quantifying the business impact of seismic technology to deepwater exploration.” Bandura describes how to communicate technological value and expertise to decision makers. Other topics include how to tie work to financial metrics, the power of simplicity and brevity, and how geoscientists can better understand decision makers. Hear the full episode at https://seg.org/podcast/post/13672 .
Oligometastatic Disease in the Liver: The Role of Interventional Oncology
Authors: Adnan Ather , Sheth Rahul Anil , Tam Alda
Published: March 2022

Oligometastatic disease represents a clinically discrete intermediate stage of cancer progression and is an expanding area of research. While surgical metastatectomy has been recognized for decades as an effective treatment option in select patients, options for metastasis-directed therapy have broadened in scope with advancements in the armamentarium of non- and minimally invasive modalities. Recent preclinical studies investigating the immunology surrounding liver metastases demonstrate treatment resistance to immunotherapy in affected patients and show how locoregional therapy has the ability to overcome this resistance. In this paper, we review advancements in our understanding of oligometastatic disease, metastasis-directed therapy, effect of liver metastasis on response to immunotherapy, and the burgeoning role of image-guided interventions in complementing cancer immunotherapy at the exciting crossroads of interventional oncology and immuno-oncology.
Cercetari privind influenta unor factori ecologici si tehnologici asupra recoltei si a calitatii la grau
Authors: Ρούση Βασιλική
Published: March 2022

Το σιτάρι είναι μια σημαντική καλλιέργεια στην Ελλάδα, καλύπτοντας περίπου 700.000 εκτάρια, εκ των οποίων το 70% της έκτασης καλλιεργείται με Σίτο σκληρό, Triticum durum, που χρησιμοποιείται για ζυμαρικά και το υπόλοιπο με Σίτο μαλακό Triticum aestivum vulgare , που χρησιμοποιείται για παραγωγή άρτου και ζωοτροφών. Η μέση απόδοση που καταγράφηκε την τελευταία δεκαετία στην Ελλάδα ήταν μεταξύ 1900-300kg/στρέμμα με τις δυνατότητες των τρεχουσών ποικιλιών. Το 1,4% της συνολικής έκτασης καλλιεργείται με βιολογικό σιτάρι, το οποίο αποτελεί και μέρος της ερευνητικής κατεύθυνσης. Στις ευρωπαϊκές χώρες, η Ρουμανία είναι μεταξύ των μεγαλύτερων καλλιεργητών σίτου που καλλιεργεί περίπου 2 εκατομμύρια εκτάρια με μέσο όρο 2000-3500 kg/ha (κάτω από τις πιθανές κλιματικές συνθήκες στη χώρα, θα μπορούσε να έχει κατά μέσο όρο περίπου 6000 kg/ha. Η επιλογή ποικιλίας και η λίπανση είναι σημαντικοί παράγοντες για την επίτευξη υψηλών αποδόσεων και ως εκ τούτου η αιτιολογική σκέψη και η κατεύθυνση της διενέργειας της παρούσας έρευνας. Η έρευνα διεξήχθη παράλληλα, στην Ελλάδα και τη Ρουμανία. Στην Ελλάδα στόχος της έρευνας ήταν η καλλιέργεια σιταριού που συμβάλλει στο οικολογικό σύστημα, χρησιμοποιώντας μόνο οργανικά λιπάσματα (σύμφωνα με τον κανονισμό (ΕΟΚ) αριθ. 2092/91 του Συμβουλίου).Στη Ρουμανία, οι ερευνητικοί στόχοι ήταν να βοηθήσουν στον προσδιορισμό της δομής των Ελληνικών ειδών και ποικιλιών, αναζητώντας τρόπο να βελτιστοποιήσουν τη λίπανσή τους, συνδυάζοντας τα αποτελέσματα αυτών των σημαντικών τεχνολογικών δεσμών στην ποιότητα των σιτηρών. Έρευνες στην Ελλάδα, που διεξήχθησαν στον πειραματικό κύκλο 2008-2010, έχουν αναδείξει τη δυνατότητα απόκτησης βιολογικού ψωμιού σιταριού και ζυμαρικών, με δείκτες ανώτερης ποιότητας. Τα αποτελέσματα της συγκομιδής που ελήφθησαν στο πειραματικό πεδίο στην Ελλάδα έδειξαν ότι ποικιλίες του είδους Triticum aestivum vulgare και ποικιλίες που ανήκουν στο είδος Triticum durum υπό εφαρμογή οργανικής λίπανση, αντέδρασαν με θετικά οικονομικά αποτελέσματα.
Σύνθεση και χαρακτηρισμός συμπλόκων ενώσεων Ru και εφαρμογές τους σε αντιδράσεις μεταφοράς υδρογόνου και σε αντιδράσεις α,β-αλκυλίωσης
Authors: Ζαχαρόπουλος Νικόλαος
Published: March 2022

Οι καταλυτικές αντιδράσεις υδρογόνωσης με μεταφορά σε ακόρεστα υποστρώματα είναι μια εξαιρετική εναλλακτική μέθοδος σύνθεσης κορεσμένων προϊόντων σε ήπιες συνθήκες. Επιπλέον, οι καταλυτικές αντιδράσεις α,β-αλκυλίωσης είναι αντίδρασεις σύζευξης που ακολουθούν τις αρχές της οικονομίας ατόμου, καθώς το μοναδίκο παραπροϊόν είναι το νερό. Υπάρχει συνεχής ανάγκη στη ανάπτυξη νέων καταλυτικών συστημάτων για τις δύο αυτές διεργασίες. Σε αυτή τη Διδακτορική Διατριβή συντεθήκαν νέοι πρόδρομοι καταλύτες του Ru(II) με χημικό τύπο [Rup-cymene)LCl]X, X= PF6- και [Ru(p-cymene)Cl3]- και τύπου [RuL(PPH3)2Cl2]. Ως υποκαταστάτες L επιλεχτήκαν παράγωγα της 2,2΄πυριδυλο-κινολίνης και της 2,2΄-δικινολίνης. Οι νέες ενώσεις χαρακτηρίστηκαν με φασματοσκοπικές τεχνικές και με κρυσταλλογραφία ακτίνων-Χ.Οι νέοι πρόδρομοι καταλύτες εξετάστηκαν σε αντιδράσεις υδρογόνωσης με μεταφορά, για την αναγωγή υποστρωμάτων αρωματικών κετονών, χρησιμοποιώντας την 2-προπανόλη ως δότη «υδρογόνου» και ισχυρή βάση. Οπου ήταν δυνατό έγινε σύνθεση του ενεργού καταλύτη και προτάθηκε πιθανός μηχανισμός της αντιδρασης.Ακόμα, μελετήθηκε η δράση τους ως καταλύτες και στις αντιδράσεις α- αλκυλίωσης πρωτοταγών αλκοολών με κετόνες, καθώς και σε αντιδράσεις β-αλκυλίωσης δευτεροταγών αλκοολών με πρωτοταγείς αλκοόλες. Οι καταλυτικές διεργασίες έγιναν σε διαλύτη τολουόλιο, παρουσία ισχυρής βάσης.
Flexible Sub-bands F-OFDM Configured for Spectrum Efficiency Enhancement in 5G System
Authors:   Coll. of Electronics Eng. Ninevah University, Ninevah, Iraq, Ali Dia M. , Yahya Zhraa Zuheir
Published: March 2022

The new product of wireless communication systems, the Fifth generation (5G), promises higher data rates and Spectrum Efficiency (SE) enhancements to support the communication of heterogeneous services. The Filtered-OFDM (F-OFDM) technique was proposed as the strongest candidate waveform for the physical layer in 5G to fulfill these requirements. In F-OFDM, the whole band is split into narrow sub-bands, each filtered by a digital Finite Impulse Response (FIR) filter with different specifications to increase the spectrum utilization and allow for asynchronous transmission. This paper proposes a novel F-OFDM design waveform for the first time with four sub-bands in equal and unequal sub-band sizes of seven kinds of window sinc filters and a variety of numerology designs to observe SE enhancement using Matlab-Simulink Software. Simulation results show that F-OFDM can reduce Out-Of-Band Emission (OOBE) and achieve SE of about (5%-6%) higher than conventional OFDM for equal and unequal sized sub-bands, respectively, by optimizing the guard band between the designed sub-bands, which achieves 5G guard band requirements.
Optimal Interference for Device to Device Communication Underlaying Cellular Network
Authors:   School of Electronics and Telecommunications, Hanoi University of Science and Technology, No1 Dai Co Viet, Hai Ba Trung, Hanoi, 10000, Vietnam, Van Nguyen Ngoc
Published: March 2022

Device to Device (D2D) communication can effectively improve the spectrum eficiency and reduce the load of Base Station in cellular networks. However, when D2D users and cellular users share the wireless channels, it will bring signal interference for the cellular networks. In order to achieve mutual interference between users and base stations, and increase the spectrumutilization efficiency and energy utilization efficiency, this paper proposes a method control algorithm based on bearnforrning and interference alignment in D2D communication underlaying cellular networks. Simulation results show that the proposed algorithm can effectively reduce the interference of the BS transrnitting signal for D2D pais and significantly improve system capacity. Furthermore, D2D communication is more applicable to short-range links.
The Shell Motif in the Culture and Architecture of the Ancient Town of Marina el-Alamein in Egypt
Authors: Bąkowska-Czerner Grażyna , Czerner Rafał
Published: March 2022

At the archaeological site of Marina el-Alamein in Egypt, many monuments and everyday objects feature motifs related to Aphrodite and her cult. One recurring theme is the seashell that lamps are often decorated with. In one case, it accompanies the depiction of the goddess herself. This article collects oil lamps with the image of a scallop shell from the research of the Polish-Egyptian Conservation Mission, as well as already published specimens from earlier archaeological research. It has been noted to date that this motif is one of the most common on lamps found in Marina el-Alamein. Shells also appear on architectural elements – in the finials of niches with a religious purpose, located in the main reception halls of houses. In such aediculae they are well exposed, but the use of shells does not arise from the shape of the architectural framing. Therefore, other reasons, possibly symbolic ones, for including this motif in decoration should be considered.
Mapping Metal Rich Roman Cyprus: The Case for Object-Centred Approaches
Authors: Hussein Ersin
Published: March 2022

This paper makes the case for developing ongoing research on Roman Cyprus’s metal profile by integrating object-centred approaches. It does so by focusing on the British Museum’s Cypriot collection as it contains a significant number of metal artefacts. The paper opens with a brief overview of key ancient evidence and the impact of recent, multidisciplinary approaches before introducing the collection and the data assembled for this case study. Assessment of this body of evidence highlights the benefits of undertaking systematic study of metalware related to Cyprus. A museological approach that focuses on the materiality of objects will also demonstrate how lines of enquiry can be developed to enhance current investigations of mining, metallurgy, and metal consumption across the island as well as shed further light on the role and cultural value of metals. This has huge implications for the study of Roman Cyprus and the wider Roman Mediterranean.
Colonnaded Hall in Kourion: How the Oecus Corinthius Was Interpreted in the Roman Houses of Cyprus
Authors: Pensabene Patrizio , Gasparini Eleonora
Published: March 2022

This contribution analyses the architecture of the public reception area of a house in Kourion, on the southern coast of Cyprus. Known as the Early Christian House due to the discovery of a later phase, characterised above all by mosaics, the house, which is only partially excavated, boasts architectural features that date back to the Hellenistic era. These sprang from official Alexandrian models that subsequently spread across the Mediterranean. In territories such as Cyprus, where ties with the Ptolemaic Kingdom were close, this new form of architectural expression continued to flourish, with transformations and elements of innovation, even during the Imperial Age. In the Early Christian House this phenomenon is particularly evident in a colonnaded room in which the model defined by Vitruvius, the Oecus Corinthius appears. In this particular instance, the style is embellished with the use of simplified capitals and angular heart-shaped pillars of the Doric order. The architectural elements of the house are analysed here in order to provide a stylistic and chronological framework what contribute to the reconstruction of the history of the early Imperial phase of the building.
El reglamento (UE) 650 de 2012 de sucesiones internacionales y el paradigma forum/ius. Una mirada a su proceso de creación y a su desarrollo jurisprudencial
Authors: Alarcón Palacio Yadira Elena
Published: March 2022

Se estudia el proceso de unificación que sufrió la UE para la adopción del RES 650/2012 que se convierte en un ejemplo para otros ejercicios de DIPr, deteniéndonos en el paradigma de unificación fórum/ius de la residencia habitual del causante o la ley de su nacionalidad en caso de professio iuris. El recorrido comprende los antecedentes de la Conferencia de la Haya de DIPr como base jurídica para la unificación en materia sucesoria; el proceso en Europa que llevó a la unificación y un análisis de los rasgos que caracterizan los factores de atribución de competencia y de determinación de la ley aplicable. Se concluye que el gran logro de un instrumento de esta naturaleza sólo se compara con el reto de su implementación que pasa por el reconocimiento del Certificado Sucesorio Europeo (CSE) en los 25 países, así como su adaptabilidad a otros reglamentos de materias conexas como el Reglamento de regímenes matrimoniales (RREM, 2016/1103) y la cobertura de otros fenómenos sociales emergentes, retos para los cuales jugará un papel determinante la jurisprudencia del TJEU.
Pemanfaatan Teknologi Informasi Dan Komunikasi Dalam Supervisi Pembelajaran Di SDN Kabupaten Minahasa Utara
Authors: Pondaag Marshela , Rawis Joulanda A.M , Wullur Mozes Markus
Published: March 2022

Perkembangan dan pemanfaatan teknologi informasi dan komunikasi (TIK) untuk pendidikan dapat memungkinkan pembaharuan pada sistem pendidikan menjadi meningkat. Akibat minimnya infrastruktur seperti laboratorium komputer dan penguasaan TIK di kondisi SDN di Minahasa Utara saat ini, guru mengalami beberapa kendala dalam implementasi proses pendidikan dan pengajaran (TIK) di sekolah, Guru memberikan pengajaran/pelatihan TIK bagi guru di SDN Kabupaten Minahasa Utara melalui kegiatan transfer ilmu dan menggunakan TIK saat aktifitas belajar. Metode yang digunakan adalah ceramah, diskusi, dan pelatihan. Diajarkan Aplikasi yang adalah flash, e-learning, dan learning management system merupakan pengenalan Microsoft Word dan lebihdalam. Sesudah mengikuti kursus ini, para guru akan mendapatkan pengetahuan dan pengertian tentang berbagai aplikasi TIK dan akan termotivasi untuk menguasai dan memaksimalkan pemanfaatan TIK untuk KMB di kelas..
Evaluasi Kompetensi Guru SMA di Manggelewa Dompu
Authors: Haryadi Didit , Islamiah Muarif
Published: March 2022

Kualitas kompetensi guru dapat mempengaruhi kualitas pendidikan.  Adapun tujuan dari penelitian ini adalah (1) untuk mengetahui Kompetensi Pedagogik (2) untuk mengetahui kompetensi sosial (3) untuk mengetahui kompetensi kepribadian dan (4) untuk mengetahui kompetensi profesional Guru di SMA Negeri 1 Manggelewa.

Penelitian ini merupakan jenis penelitian Evaluasi. Penelitian evaluasi di gunakan karena di dalam penelitian memuat evaluasi yang berkaitan kompetensi guru di SMA Negeri 1 Manggelewa. subjek penelitian adalah Guru di SMA Negeri 1 Manggelewa yang berjumlah 20 orang. Teknik pengumpulan data berupa Angket dengan skala likert 1 sampai dengan 4  dan dibantu wawancara untuk mendapatkan informasi awal atau kondisi empiris sekolah. Teknik analisis data yang digunakan adalah deskriptif kuantitaf  dengan menggunakan analisa deskriptik atau statistik deksriptik. Cara menarik kesimpulan adalah dengan melihat hasil dari tiap komponen dan membandingkan dengan tabel presentase dari bukunya Prof. Sugiyono sehingga dapat ditarik kesimpulan tiap kompenen atau Kompetensi kurang baik atau sangat baik

Dari penelitian dapat di simpulkan (1) Kompetensi Pedagogik di SMA Negeri 1 Manggelewa sangat baik berdasarkan deskripsi data yang sudah dilakukan dengan presentase 85 % (2) Kompetensi Sosial di SMA Negeri 1 Manggelewa sangat baik berdasarkan deskripsi data yang sudah dilakukan dengan presentase 88 % (3) Kompetensi Kepribadian di SMA Negeri 1 Manggelewa sangat baik berdasarkan deskripsi data yang sudah dilakukan dengan presentase 88 % (4) Kompetensi Profesional di SMA Negeri 1 Manggelewa sangat baik berdasarkan deskripsi data yang sudah dilakukan dengan presentase 85 %. Secara keseluruhan Kompetensi Guru di SMA Negeri 1 Manggelewa sangat baik.
Kinerja Dosen Di Lingkungan Politeknik Negeri Manado Ditinjau Dari Aspek Supervisi Direktur
Authors: Hosang Merci , Rawis Joulanda A.M , Wullur Mozes Markus , Rotty Viktory N. J
Published: March 2022

Penelitian ini bertujuan untuk mengetahui efektivitas pengawasan direktur terhadap prestasi kerja Institut Teknologi Negeri Manado. Populasi penelitian ini adalah 100 orang dosen Institut Teknologi Negeri Manado. Semua teknik pengambilan sampel digunakan dalam penelitian ini, dan semua 100 anggota populasi digunakan sebagai partisipan. Pengumpulan data survei ini dengan kuesioner. Teknik analisis data menggunakan regresi linier dengan taraf signifikansi 5%. Hasil penelitian menunjukkan bahwa pengaruh efektif pengawasan direktur berpengaruh positif sangat signifikan terhadap prestasi kerja Institut Teknologi Negeri Manado. Hal ini diperkuat dengan hasil perhitungan statistik yaitu kontribusi efektif pengawasan direksi sebesar 23,6%. Artinya 72,4% berkontribusi secara simultan dari faktor lain. Guru memegang peranan vital dalam keberhasilan proses pendidikan dan pembelajaran sebagai elemen terpenting dari proses pendidikan dan pembelajaran kampus. Dalam penelitian saat ini, peneliti antusias mempelajari kinerja guru di lingkungan.
Evaluation of a nurse-led intervention to improve adherence to secondary prevention of rheumatic heart disease
Authors: Thomas Nisha , Kaur Sukhpal , Saxena Anita
Published: March 2022

Background/Aims

Rheumatic heart disease is a major health concern in India. Secondary prevention following acute rheumatic fever can prevent disease escalation, but adherence rates are often low. This study evaluated whether a nurse-led intervention could effectively increase adherence rates to secondary prevention and reduce rheumatic symptoms in this patient group.

Methods

A total of 60 patients were randomly assigned to either an intervention or control group. The control group received standard treatment, while the intervention group received a 25-minute education session with a nurse, along with text message or phone call reminders before they were due for treatment. Participants also completed a rheumatic morbidity index scale survey over 12 months to record their symptoms. A two-way sample t-test was used to compare adherence rates and symptom incidence in both groups.

Results

Patients in the intervention group had significantly better adherence rates to their medication, receiving 11–17 of the total 18 injections over the 12-month period, compared to 6–12 in the control group. They were also less likely to experience symptoms of rheumatic heart disease or require emergency hospitalisation.

Conclusions

A nurse-led intervention is an effective method of reducing pressure on hospital services and increasing treatment adherence among patients receiving secondary prevention treatment for rheumatic heart disease.
Study of Seasonal, Spatial Deviation and Pollution Indices of Ground Water by Tannery Activities in Vaniyambadi, Vellore district, Tamilnadu, India
Authors: S. Vasanthan S. Vasanthan , A. Murugesan A. Murugesan , A. Selvam A. Selvam
Published: March 2022

The purpose of this study was to investigate the physicochemical properties and the presence of heavy metals in groundwater samples. This study was carried out on the site of a tanneries of Vaniyambadi Taluk in the Vellore district. Evaluate the pollution index and risk assessment to assess the suitability of groundwater for human consumption. The information absorbed Physico-chemical properties and heavy metals like., Copper, Chromium, Lead, Zinc, Nickel, Aluminum, Cadmium contamination of groundwater samples. Flame AAS (Atomic Absorption Spectrometer) method used to assess the heavy metals concentration, The metal strength of groundwater in the area of the tanneries is rather high. As a result of the analysis, it was found that the chromium concentration was quite high in the groundwater samples from the tanneries, and the strengths of copper, chromium, lead, zinc, nickel, aluminum, and cadmium metals were also found slightly higher in groundwater in the tannery area. The calculated pollution indices, the Contamination Index (CI) and the Environmental risk Index (IER) for heavy metals, indicate that the majority of the groundwater samples studied are in severely contaminated areas. All physicochemical properties are within the normal range and metal contamination of groundwater is responsible for maintaining the harmfulness of crops and household needs.
Sol Gel Synthesis and Characterization of Strontium Titanates
Authors: Ramanjeet Kaur Ramanjeet Kaur , Anand K Tyagi Anand K Tyagi
Published: March 2022

Pure strontium titanates have been successfully fabricated in this work via sol gel route. The obtained powders were calcined at various temperatures and effects of calcination and sintering on phase development, crystallite size, lattice parameters, microstructure etc. were investigated by XRD and SEM techniques. The development of phase with temperature has been investigated using DTA/TG technique. The dielectric and electrical parameters were analyzed and effects of temperature and frequency variation on these parameters were studied.
Visible Light Degradation of Rose Bengal Dye with a Novel WO2/ZnMoO4 Nanocomposite as Photocatalyst
Authors: Sudhakar. C Sudhakar. C , Devi. R Devi. R , Nikhil. S Nikhil. S , Kalyani. P Kalyani. P , Suganthi. A Suganthi. A , Rajarajan. M Rajarajan. M
Published: March 2022

The fabrication of WO2/α-ZnMoO4 nanocomposite using a novel chemical aqueous technique is described in this research. This treatment is mild, easy to use, affordable, and successful. The samples were described using XRD, FT-IR, SEM, EDX, and UV-DRS as they were created. The WO2/α-ZnMoO4 is seen in the visible portion of the DRS (Diffuse Reflectance Spectroscopy). The structural and morphological features of the generated WO2/α-ZnMoO4 nanocomposite were examined using SEM. The photocatalytic activity of WO2/α-ZnMoO4 nanocomposite for the Rose Bengal degradation was investigated in depth under visible light. The WO2/α-ZnMoO4 nanocomposite had the best photodynamic performance (59 percent to 96 percent of RB degradation). Adsorption of Rose Bengal came next. Using a kinetic pseudo-first order kinetics, the samples' exceptional stability was tested four times under visible light using photodegradation RB. The relationship between structure of the WO2/α-ZnMoO4 nanocomposite and photocatalytic activity, are investigated. As a result, the method of preparation throws light on the photocatalytic destruction of organic pollutants using WO2/α-ZnMoO4 nanocomposite.
Association between the Orthopaedic Trauma Society classification of open fractures and economic costs
Authors: Png May Ee , Petrou Stavros , Bourget-Murray Jonathan , Knight Ruth , Trompeter Alex J. , Costa Matt L.
Published: March 2022

Aims

The aim of this study was to investigate the relationship between the Orthopaedic Trauma Society (OTS) classification of open fractures and economic costs.

Methods

Resource use was measured during the six months that followed open fractures of the lower limb in 748 adults recruited as part of two large clinical trials within the UK Major Trauma Research Network. Resource inputs were valued using unit costs drawn from primary and secondary sources. Economic costs (GBP sterling, 2017 to 2018 prices), estimated from both a NHS and Personal Social Services (PSS) perspective, were related to the degree of complexity of the open fracture based on the OTS classification.

Results

Adjusted mean total NHS and PSS costs were £13,785 following treatment of complex fractures and £3,550 following treatment of simple fractures, where the open fracture wound is closed at the end of the first wound debridement, generating a mean difference of £10,235 (95% confidence interval £8,074 to £12,396).

Conclusion

Following previous work correlating clinical outcomes with the OTS classification of open fractures, this study suggests that the new OTS classification also correlates with economic costs estimated from alternative study perspectives. Cite this article: Bone Joint J 2022;104-B(3):408–412.
Surgeons and pregnancy
Authors: Dean Erin
Published: March 2022

Surgeons are twice as likely to experience difficulties with pregnancy and childbirth. Erin Dean looks at how we can make the experience of surgeons easier.
Lights, camera, operate!
Authors: Kerstein Ryan
Published: March 2022

Our Techonologist looks at cutting edge camera technology being used to operate by surgeons.
A call for action: time to eradicate sexual assault and harassment from the surgical workplace
Authors: Pegna V , Grossman R , Cuming T
Published: March 2022

The Bulletin has ignited the conversation around sexual assault in surgery, resulting in an avalanche of personal testimonies and calls for action to change surgical culture. Victoria Pegna et al detail the steps they have planned to tackle the problem.
COP26: The eternally weak pulse of climate diplomacy, and what needs to change
Authors: Harris Paul G.
Published: March 2022

COP26 was noteworthy for a shift in attitude toward the kind of worldwide action that is essential to address the climate crisis effectively. More governments and industries are saying the right things. However, like the 25 preceding COPs, COP26 failed to reach agreement that will soon cut global GHG pollution, let alone prevent dangerous climate change. It was another example of the trudging negotiations and tenuous promises that have characterized climate diplomacy over three decades. To avoid decades more of plodding climate diplomacy, something needs to change. The twenty-sixth conference of the parties (COP26) to the United Nations Framework Convention on Climate Change (UNFCCC), which met in Glasgow, Scotland, last November, was billed as the most important episode in climate diplomacy since the 2015 Paris Agreement. In the event, it was another example of the trudging negotiations and tenuous promises that have characterized climate diplomacy over three decades.
Factors that mediate the relationships between household socio-economic status and childhood Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents: A systematic review
Authors: Markham Wolfgang A. , Spencer Nicholas
Published: March 2022

Background

ADHD is one of the most prevalent mental health disorders among children and adolescents. Household socio-economic status (SES) in early childhood is inversely related to ADHD later in childhood or adolescence. We conducted a systematic review to examine psychological, social and behavioural factors that mediate these relationships (PROSPERO Registration number: CRD42020182832).

Methods and findings

We searched Medline, EMBASE, PsychINFo, and Web of Science from inception until May 2020. Both authors independently reviewed abstracts and identified papers for inclusion. We sought primary observational studies (cohort, cross-sectional and case control studies) of general population-based samples of children and adolescents aged 18 and under that investigated potential mediators of the relationships between SES and ADHD. Studies based upon non-general population-based samples, twins or biochemical/physiological changes were excluded. Direct and indirect effects derived from standard validated mediation analysis were extracted for potential mediators. We assessed risk of bias using a modified NIH tool and synthesised quantitative data without meta-analysis according to the (SWiM) protocol because of heterogeneity between included studies.

Family adversity, paternal and maternal ADHD symptoms, Home Learning Environment, breastfeeding duration and a combined fine motor and language score at age 2 may lie on the SES-ADHD pathway. Evidence concerning the influence of maternal depression/anxiety and adverse parenting was inconsistent across studies. There was no evidence that mother’s health-related behaviour, family characteristics, child’s consumption of fizzy drinks or other developmental characteristics at birth/during infancy lie on the SES-ADHD pathway. Publication bias may have been introduced by our decision not to search grey literature, not to approach study authors and limit the search to the English language.

Conclusions

Evidence for mediation of the SES-ADHD pathway in childhood/adolescence is under-researched. Maternal mental health, family adversity, parenting and health-related behaviours warrant further research based on longitudinal data and employing the most advanced mediation analysis methods.
Strategies to improve access to cognitive behavioral therapies for anxiety disorders: A scoping review
Authors: Carrier Jean-Daniel , Gallagher Frances , Vanasse Alain , Roberge Pasquale
Published: March 2022

Background

Strategies to improve access to evidence-based psychological treatments (EBPTs) include but are not limited to implementation strategies. No currently available framework accounts for the full scope of strategies available to allow stakeholders to improve access to EBPTs. Anxiety disorders are common and impactful mental conditions for which EBPTs, especially cognitive-behavioral therapies (CBT), are well-established yet often hard to access.

Objective

Describe and classify the various strategies reported to improve access to CBT for anxiety disorders.

Methods

Scoping review with a keyword search of several databases + additional grey literature documents reporting on strategies to improve access to CBT for anxiety disorders. A thematic and inductive analysis of data based on grounded theory principles was conducted using NVivo.

Results

We propose to classify strategies to improve access to CBT for anxiety disorders as either "Contributing to the evidence base," "Identifying CBT delivery modalities to adopt in practice," "Building capacity for CBT delivery," "Attuning the process of access to local needs," "Engaging potential service users," or "Improving programs and policies." Each of these strategies is defined, and critical information for their operationalization is provided, including the actors that could be involved in their implementation.

Implications

This scoping review highlights gaps in implementation research regarding improving access to EBPTs that should be accounted for in future studies.
Identifying beneficiaries for sustainable development in low- and middle-income countries
Authors: Roy Arindam
Published: March 2022

Implementation projects on sustainable development have already triggered the global transfer of funds through multi-lateral agencies. The selection of beneficiaries at the local level is an intriguing problem in the developmental sector and does not have a single-window solution. In absence of equitable selection, a fraction of beneficiaries might be benefitted over and over again and the rest remain deprived. The proposed opinion will discuss the challenges of selecting beneficiaries in the developing countries and shade lights in some of the probable solutions which can be used. The present opinion also suggest measures needs to be taken by funding agency, and implementing agency to create more transparent framework and assure maximal utilization of available funds.
Novel ecosystemic awareness: Singing-dancing-laughing with Earth
Authors: Weig Doerte
Published: March 2022

When was the last time you danced and sang together with other people, just for the joy of it? As the COVID pandemic exacerbates mental health issues, we are seeing also a rise in so-called eco-anxiety. Awareness of humans forming part of larger ecologies can no longer be ignored as a medically relevant topic. Can contemporary eco-somatic practices contribute to shifting eco-anxieties, and to shaping human awareness of ecosystemic diversity and embeddedness? Singing–dancing together are time-honoured ways of maintaining and restoring individual or group health and happiness, and engendering embeddedness. Drawing on research with egalitarian Baka groups in Central Africa and with shifting–sliding fascia connective tissues, the proposition made here is to activate singing–dancing–laughing, not only as a method of somatic vocal training or pedagogy, but also as a way of shaping community and honouring ecosystemic nestedness. Through this, we may further come to appreciate Earth as co-guider in eco-somatic practices.
Models and Algorithms for Social Distancing in Order to Stop the Spread of COVID-19
Authors: Popa Alexandru
Published: March 2022

Currently there are many attempts around the world to use computers, smartphones, tablets and other electronic devices in order to stop the spread of COVID-19. Most of these attempts focus on collecting information about infected people, in order to help healthy people avoid contact with them. However, social distancing decisions are still taken by the governments empirically. That is, the authorities do not have an automated tool to recommend which decisions to make in order to maximize social distancing and to minimize the impact for the economy.

In this paper we address the aforementioned problem and we design an algorithm that provides social distancing methods (i.e., what schools, shops, factories, etc. to close) that are efficient (i.e., that help reduce the spread of the virus) and have low impact on the economy.

On short: a) we propose several models (i.e., combinatorial optimization problems); b) we show some theoretical results regarding the computational complexity of the formulated problems; c) we give an algorithm for the most complex of the previously formulated problems; d) we implement and test our algorithm.
Dense Languages and Non Primitive Words
Authors: Koga Toshihiro
Published: March 2022

In this paper, we are concerned with dense languages and non primitive words. A language L is said to be dense if any string can be found as a substring of element of L. In 2020, Ryoma Syn'ya proved that any regular language with positive asymptotic density always containsinfinitely many non-primitive words. Since positive asymptotic density implies density, it is natural to ask whether his result can be generalized for a wider class of dense languages. In this paper, we actually obtain such generalization.
General Systems Theory and Remanufacturing / Teoría general de sistemas y remanufactura
Authors: Rodrigues Glauco Oliveira , Schuch Crislei Daiana Oliveira Siqueira , Antunes Marcelo Cassanta , Piovesan Carlos
Published: March 2022

The general systems theory emerged from the works of the Austrian biologist Ludwig von Bertalanffy, published between 1950 and 1968. This theory has as its main purpose, to analyze the nature of systems and the interrelationship between these systems and different spaces, as well as the interrelationship of its parts. It also analyzes the fundamental laws of systems. Remanufacture, in turn, is an industrial process that consists of the steps of dismantling the discarded or already used product, the remanufacturing process includes the steps of cleaning its parts, repairing, or replacing damaged parts. This article aims to analyze the prose academic productions of the last ten years. Bibliometric analysis was performed through the Web of Science platform. : La teoría general de sistemas surgió a partir de los trabajos del biólogo austriaco Ludwig von Bertalanffy, publicados entre 1950 y 1968. Esta teoría tiene como objetivo principal analizar la naturaleza de los sistemas y la interrelación entre estos sistemas y diferentes espacios, como así como la interrelación de sus partes. También analiza las leyes fundamentales de los sistemas. La remanufactura, a su vez, es un proceso industrial que consiste en los pasos de desmantelar el producto desechado o ya usado, el proceso de remanufactura incluye los pasos de limpiar sus partes, reparar o reemplazar las partes dañadas. Este artículo tiene como objetivo analizar las producciones académicas en prosa de los últimos diez años. El análisis bibliométrico se realizó a través de la plataforma web of Science.
Marketing de Guerrilha do Twitter / Guerrilla Marketing on Twitter
Authors: Korczagin Daiana , Cembranel Priscila
Published: March 2022

O objetivo da pesquisa foi analisar a percepção dos consumidores de ambas as empresas a respeito das influências do marketing de guerrilha na rede social Twitter. O estudo se desenvolveu por meio de abordagem qualitativa, procedimento de análise da rede social e técnica de questionário para contribuir com o gap de pesquisa a respeito das práticas de marketing de guerrilha na rede social Twitter e como suas abordagens contundentes buscam gerar chamar a atenção dos consumidores. Aborda a influência da estratégia de marketing de guerrilha - criada inicialmente para as mídias tradicionais - adaptada para atrair clientes e usuários na cibercultura por meio de “memes” nas redes sociais. Os resultados demonstram que o marketing de guerrilha influencia os usuários devido às estratégias baseadas em publicações competitivas, por falar dos alimentos de forma interativa e devido a criatividade, inovação, engajamento e diversão das publicações das empresas. Assim, contribui com a literatura ao demonstrar a percepção dos usuários da rede social Twitter e fornece insights para práticas de divulgação nas redes sociais e como adotar a estratégia de marketing de guerrilha.Abstract: The objective of the research was to analyze the perception of consumers from both companies regarding the influences of guerrilla marketing on the social network Twitter.The study was disseminated through a qualitative approach, a social network analysis procedure and a technical questionnaire to respond to the research gap regarding guerrilla marketing practices on the Twitter social network and how its forceful options seek to attract the attention of consumers. It addresses the influence of the guerrilla marketing strategy - initially created for traditional media - adapted to attract customers and users in cyberculture through “memes” on social networks. The results demonstrate that guerrilla marketing influences users due to clinics based on competitive publications, talking about food in an interactive way and due to creativity, innovation, engagement and fun of company publications. So, contributes to the literature by demonstrating the perception of users of the social network Twitter and offers insights into outreach practices on social media and how to adopt the guerrilla marketing strategy.