bluuebunny/crossref_metadata_2025 huggingface dataset:
Well-Posedness of the Two-Dimensional Compressible Plasma-Vacuum Interface Problem
Authors: Morando Alessandro , Secchi Paolo , Trakhinin Yuri , Trebeschi Paola , Yuan Difan
Published: June 2024

We consider the two-dimensional plasma-vacuum interface problem in ideal compressible magnetohydrodynamics (MHD). This is a hyperbolic-elliptic coupled system with a characteristic free boundary. In the plasma region the 2D planar flow is governed by the hyperbolic equations of ideal compressible MHD, while in the vacuum region the magnetic field obeys the elliptic system of pre-Maxwell dynamics. At the free interface moving with the velocity of plasma particles, the total pressure is continuous and the magnetic field on both sides is tangent to the boundary. The plasma-vacuum system is not isolated from the outside world, since it is driven by a given surface current which forces oscillations onto the system. We prove the local-in-time existence and uniqueness of solutions to this nonlinear free boundary problem, provided that at least one of the two magnetic fields, in the plasma or in the vacuum region, is non-zero at each point of the initial interface. The proof follows from the analysis of the linearized MHD equations in the plasma region and the elliptic system for the vacuum magnetic field, suitable tame estimates in Sobolev spaces for the full linearized problem, and a Nash–Moser iteration.
Patients with Periprosthetic Femoral Hip Fractures are Commonly Classified as Having Osteoporosis Based on DXA Measurements
Authors: Ritter Jacob , Alimy Assil-Ramin , Simon Alexander , Hubert Jan , Ries Christian , Rolvien Tim , Beil Frank Timo
Published: June 2024

Periprosthetic femoral hip fractures are subject to an increasing incidence and are often considered to be related to osteoporosis. However, there are no available studies that have determined the frequency of osteoporosis in affected patients using gold standard dual-energy X-ray absorptiometry (DXA). In this retrospective comparative study, we analyzed the DXA results of 40 patients with periprosthetic femoral hip fractures who were treated surgically in our department. DXA measurements were performed at the total hip and the lumbar spine to determine bone mineral density T-scores. Data were compared to two age-, sex-, and BMI-matched control groups in which patients underwent DXA prior to aseptic revision surgery for other causes or primary THA (consisting of 40 patients each). The mean T-score in the periprosthetic fracture cohort was significantly lower (− 1.78 ± 1.78) than that of the aseptic revision (− 0.65 ± 1.58, mean difference − 1.13 [95% CI − 1.88 to − 0.37]; p = 0.001) and the primary THA cohort (− 0.77 ± 1.34, mean difference − 1.01 [95% CI − 1.77 to − 0.26]; p = 0.005). Accordingly, osteoporosis was detected more frequently (45%) in the fracture cohort compared to patients undergoing aseptic revision (12.5%) and primary THA (10%). In conclusion, almost half of the patients with periprosthetic femoral hip fractures have osteoporosis according to DXA measurements. A regular assessment of bone health in THA enables identification of patients with osteoporosis who likely benefit from initiation of osteoporosis medication and cemented stem fixation.
Inter-island nesting dynamics and clutch survival of green turtles Chelonia mydas within a marine protected area in the Bijagós Archipelago, West Africa
Authors: Raposo Cheila , Rebelo Rui , Catry Paulo , Ferreira-Airaud Maria Betânia , Barbosa Castro , Garcia Tumbulo Bamba , Regalla Aissa , Sampaio Manuel Sá , Patrício Ana Rita
Published: June 2024

Understanding spatial heterogeneity in reproductive success among at-risk populations facing localised threats is key for conservation. Sea turtle populations often concentrate at one nesting site, diverting conservation efforts from adjacent smaller rookeries. Poilão Island, Bijagós Archipelago, Guinea-Bissau, is a notable rookery for green turtles Chelonia mydas within the João Vieira-Poilão Marine National Park, surrounded by three islands (Cavalos, Meio and João Vieira), with lower nesting activity. Poilão’s nesting suitability may decrease due to turtle population growth and sea level rise, exacerbating already high nest density. As the potential usage of secondary sites may arise, we assessed green turtle clutch survival and related threats in Poilão and its neighbouring islands. High nest density on Poilão leads to high clutch destruction by later turtles, resulting in surplus eggs on the beach surface and consequently low clutch predation (4.0%, n = 69, 2000). Here, the overall mean hatching success estimated was 67.9 ± 36.7% (n = 631, 2015–2022), contrasting with a significantly lower value on Meio in 2019 (11.9 ± 23.6%, n = 21), where clutch predation was high (83.7%, n = 98). Moderate to high clutch predation was also observed on Cavalos (36.0%, n = 64) and João Vieira (76.0%, n = 175). Cavalos and Meio likely face higher clutch flooding compared to Poilão. These findings, alongside observations of turtle exchanges between islands, may suggest a source-sink dynamic, where low reproductive output sink habitats (neighbouring islands) are utilized by migrants from Poilão (source), which currently offers the best conditions for clutch survival.
Pairwise machine learning-based automatic diagnostic platform utilizing CT images and clinical information for predicting radiotherapy locoregional recurrence in elderly esophageal cancer patients
Authors: Zhang An-du , Shi Qing-lei , Zhang Hong-tao , Duan Wen-han , Li Yang , Ruan Li , Han Yi-fan , Liu Zhi-kun , Li Hao-feng , Xiao Jia-shun , Shi Gao-feng , Wan Xiang , Wang Ren-zhi
Published: June 2024

Objective

To investigate the feasibility and accuracy of predicting locoregional recurrence (LR) in elderly patients with esophageal squamous cell cancer (ESCC) who underwent radical radiotherapy using a pairwise machine learning algorithm.

Methods

The 130 datasets enrolled were randomly divided into a training set and a testing set in a 7:3 ratio. Clinical factors were included and radiomics features were extracted from pretreatment CT scans using pyradiomics-based software, and a pairwise naive Bayes (NB) model was developed. The performance of the model was evaluated using receiver operating characteristic (ROC) curves and decision curve analysis (DCA). To facilitate practical application, we attempted to construct an automated esophageal cancer diagnosis system based on trained models.

Results

To the follow-up date, 64 patients (49.23%) had experienced LR. Ten radiomics features and two clinical factors were selected for modeling. The model demonstrated good prediction performance, with area under the ROC curve of 0.903 (0.829–0.958) for the training cohort and 0.944 (0.849–1.000) for the testing cohort. The corresponding accuracies were 0.852 and 0.914, respectively. Calibration curves showed good agreement, and DCA curve confirmed the clinical validity of the model. The model accurately predicted LR in elderly patients, with a positive predictive value of 85.71% for the testing cohort.

Conclusions

The pairwise NB model, based on pre-treatment enhanced chest CT-based radiomics and clinical factors, can accurately predict LR in elderly patients with ESCC. The esophageal cancer automated diagnostic system embedded with the pairwise NB model holds significant potential for application in clinical practice.
The VISTA/VSIG3/PSGL-1 axis: crosstalk between immune effector cells and cancer cells in invasive ductal breast carcinoma
Authors: Olbromski Mateusz , Mrozowska Monika , Piotrowska Aleksandra , Smolarz Beata , Romanowicz Hanna
Published: June 2024

A checkpoint protein called the V-domain Ig suppressor of T cell activation (VISTA) is important for controlling immune responses. Immune cells that interact with VISTA have molecules, or receptors, known as VISTA receptors. Immune system activity can be modified by the interaction between VISTA and its receptors. Since targeting VISTA or its receptors may be beneficial in certain conditions, VISTA has been studied in relation to immunotherapy for cancer and autoimmune illnesses. The purpose of this study was to examine the expression levels and interactions between VISTA and its receptors, VSIG3 and PSGL-1, in breast cancer tissues. IHC analysis revealed higher levels of proteins within the VISTA/VSIG3/PSGL-1 axis in cancer tissues than in the reference samples (mastopathies). VISTA was found in breast cancer cells and intratumoral immune cells, with membranous and cytoplasmic staining patterns. VISTA was also linked with pathological grade and VSIG3 and PSGL-1 levels. Furthermore, we discovered that the knockdown of one axis member boosted the expression of the other partners. This highlights the significance of VISTA/VSIG3/PSGL-1 in tumor stroma and microenvironment remodeling. Our findings indicate the importance of the VISTA/VSIG3/PSGL-1 axis in the molecular biology of cancer cells and the immune microenvironment.
Oligo-residual disease in PD-1/PD-L1 inhibitor-treated metastatic non-small cell lung cancer: incidence, pattern of failure, and clinical value of local consolidative therapy
Authors: Zhang Jinmeng , Gao Jie , Jiang Shanshan , Mao Jiuang , Chu Li , Chu Xiao , Yang Xi , Li Yida , Guo Tiantian , Zhou Yue , Xu Dayu , hu Jie , Chu Qian , Ni Jianjiao , Zhu Zhengfei
Published: June 2024

Objectives

To investigate the feasibility and potential clinical value of local consolidative therapy (LCT) in PD-1/PD-L1 inhibitor-treated metastatic non-small cell lung cancer (NSCLC).

Materials and methods

PD-1/PD-L1 inhibitor-treated metastatic NSCLC patients with measurable disease in three academic centers were screened and those with adequate follow-up were included. Oligo-residual disease (ORD) was defined as residual tumors limited to three organs and five lesions evaluated at the best response among patients with partial response or stable disease after PD-1/PD-L1 inhibitors. Oligometastatic and multiple-metastatic disease (OMD/MMD) were similarly classified at baseline. Locoregional interventions, administered after effective treatment of PD-1/PD-L1 inhibitors and before initial disease progression, were defined as LCT. Patterns of initial progressive disease (PD) were classified as involving only residual sites (RP), only new sites (NP), or a combination of both (BP).

Results

Among the 698 patients included, ORD was documented in 73 (47.1%) of 155 patients with baseline OMD and 60 (11.0%) of 543 patients with baseline MMD. With a median follow-up of 31.0 (range, 6.0–53.0) months, 108 patients with ORD developed initial PD, with RP, NP, and BP occurring in 51 (47%), 23 (21.3%), and 34 (31.5%), respectively. Among the 133 patients with ORD, those receiving LCT (n = 43) had longer progression-free survival (HR = 0.58, 95% CI 0.40–0.85, p = 0.01) and overall survival (HR = 0.49, 95% CI 0.30–0.79, p < 0.0001).

Conclusion

ORD occurs with a clinically relevant frequency among PD-1/PD-L1 inhibitor-treated metastatic NSCLC patients and LCT may provide extra survival benefits in those with ORD.
Clinical outcomes and biomarker exploration of first-line PD-1 inhibitors plus chemotherapy in patients with low PD-L1-expressing of gastric or gastroesophageal junction adenocarcinoma
Authors: Sun Yu-Ting , Lu Shi-Xun , Lai Ming-Yu , Yang Xia , Guan Wen-Long , Yang Li-Qiong , Li Yu-Hong , Wang Feng-Hua , Yang Da-Jun , Qiu Miao-Zhen
Published: June 2024

Background

The beneficial effects of first-line programmed death-1 (PD-1) inhibitors plus chemotherapy in patients with low programmed death-ligand 1 (PD-L1)-expressing advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma are controversial.

Methods

We conducted a retrospective analysis of patients with G/GEJ adenocarcinoma who had undergone first-line treatment with PD-1 inhibitors plus chemotherapy between October 2017 and May 2022. The primary outcomes were objective response rate (ORR) and progression-free survival (PFS). SPSS software V27.0 was used for data analysis.

Results

Of 345 enrolled patients, 290 had measurable lesions. The overall ORR was 59.3%. PD-L1 status was available in 171 patients, and 67.8% of them were considered as low PD-L1 expression level (combined positive score (CPS) < 5). Patients with PD-L1 CPS < 5 showed a lower response rate (51.1% vs 70.8%, P = 0.024) and a worse PFS (P = 0.009) compared to those with PD-L1 CPS ≥ 5. In the PD-L1 low-expression cohort, patients with non-diffuse type, GEJ cancer, synchronous metastasis, distant lymph node metastasis, liver metastasis, non-peritoneal metastasis, and HER2 positive were significantly associated with higher response rates to PD-1 inhibitors plus chemotherapy (P < 0.05). The presence of peritoneal metastasis (P = 0.028) and diffuse type (P = 0.046) were identified as independent predictors of poor PFS in multivariate analysis of the PD-L1 CPS < 5 subgroup. When evaluated for correlation with overall survival (OS) in the PD-L1 low-expression subgroup, peritoneal metastasis was found to be the only independent prognostic factor of an increased risk of death (hazard ratio: 2.31, 95% CI 1.09–4.90; P = 0.029).

Conclusions

PD-L1 CPS ≥ 5 is significantly associated with improved response and extended PFS in G/GEJ cancer patients treated with a combination of PD-1 inhibitors and chemotherapy. Specific subgroups within the low PD-L1-expressing population, such as those with non-diffuse-type tumors and without peritoneal metastases, may also benefit from immunotherapy combined with chemotherapy.
Efficacy and safety of anti-PD-1/PD-L1-based dual immunotherapies versus PD-1/PD-L1 inhibitor alone in patients with advanced solid tumor: a systematic review and meta-analysis
Authors: Chen Yueying , Han Hedong , Cheng Jing , Cheng Qinpei , Zhu Suhua , Zhan Ping , Liu Hongbing , Song Yong , Lv Tangfeng
Published: June 2024

Introduction

Numerous randomized controlled trials (RCTs) have investigated PD-1/PD-L1 inhibitor-based combination therapies. The debate surrounding the potential additive clinical benefits of combination of two immune-oncology (IO) therapies for cancer patients persists.

Methods

Both published and grey sources of randomized clinical trials that compared anti-PD-1/PD-L1-based immunotherapy combinations with monotherapy in patients with advanced or metastatic solid tumors were encompassed. The primary outcome was progression-free survival (PFS), and secondary outcomes included objective response rate (ORR), overall survival (OS) and treatment-related adverse events (TRAEs).

Results

Our analysis encompassed 32 studies comprising 10,341 patients, which covered 12 distinct immune-oncology combination regimens. Across all patients, the immunotherapy combinations exhibited the capability to enhance the ORR (OR = 1.23 [95% CI 1.13–1.34]) and extend PFS (HR = 0.91 [95% CI 0.87–0.95]). However, the observed enhancement in OS (HR = 0.96 [95% CI 0.91–1.01]) was of no significance. Greater benefits in terms of PFS (HR = 0.82 [95% CI 0.72 to 0.93]) and OS (HR = 0.85 [95% CI 0.73 to 0.99]) may be particularly pronounced in cases where PD-L1 expression is negative. Notably, despite a heightened risk of any-grade TRAEs (OR = 1.72 [95% CI 1.40–2.11]) and grade greater than or equal to 3 TRAEs (OR = 2.01 [95% CI 1.67–2.43]), toxicity was generally manageable.

Conclusions

This study suggests that incorporating an additional immunotherapy agent with PD-1/PD-L1 inhibitors can elevate the response rate and reduce the risk of disease progression, all while maintaining manageable toxicity. However, there remains a challenge in translating these primary clinical benefits into extended overall survival.
Inhibition of glycolysis enhances the efficacy of immunotherapy via PDK-mediated upregulation of PD-L1
Authors: Zhang Ruizhi , Mao Gan , Tang Yu , Li Chong , Gao Yisong , Nie Wenxiang , Song Tianyu , Liu Suao , Zhang Peng , Tao Kaixiong , Li Wei
Published: June 2024

Background

Immunotherapy for gastric cancer remains a challenge due to its limited efficacy. Metabolic reprogramming toward glycolysis has emerged as a promising avenue for enhancing the sensitivity of tumors to immunotherapy. Pyruvate dehydrogenase kinases (PDKs) play pivotal roles in regulating glycolysis. The importance of PDKs in the context of gastric cancer immunotherapy and their potential as therapeutic targets have not been fully explored.

Methods

PDK and PD-L1 expression was analyzed using data from the GSE66229 and The Cancer Genome Atlas (TCGA) cohorts. Additionally, the Immune Checkpoint Blockade Therapy Atlas (ICBatlas) database was utilized to assess PDK expression in an immune checkpoint blockade (ICB) therapy group. Subsequently, the upregulation of PD-L1 and the enhancement of anticancer effects achieved by targeting PDK were validated through in vivo and in vitro assays. The impact of PDK on histone acetylation was investigated using ChIP‒qPCR to detect changes in histone acetylation levels.

Results

Our analysis revealed a notable negative correlation between PD-L1 and PDK expression. Downregulation of PDK led to a significant increase in PD-L1 expression. PDK inhibition increased histone acetylation levels by promoting acetyl-CoA generation. The augmentation of acetyl-CoA production and concurrent inhibition of histone deacetylation were found to upregulate PD-L1 expression in gastric cancer cells. Additionally, we observed a significant increase in the anticancer effect of PD-L1 antibodies following treatment with a PDK inhibitor.

Conclusions

Downregulation of PDK in gastric cancer cells leads to an increase in PD-L1 expression levels, thus potentially improving the efficacy of PD-L1 immune checkpoint blockade therapy.
Reliability of glenoid measurements performed using Multiplanar Reconstruction (MPR) of Magnetic Resonance (MRI) in patients with shoulder instability
Authors: Nizinski Jan , Kaczmarek Agata , Antonik Bartosz , Rauhut Sebastian , Tuczynski Piotr , Jakubowski Filip , Slawski Julian , Stefaniak Jakub , Lubiatowski Przemyslaw
Published: June 2024

Purpose

Measurement of glenoid bone loss in the shoulder instability can be assessed by CT or MRI multiplanar imaging and is crucial for pre-operative planning. The aim of this study is to determine the intra and interobserver reliability of glenoid deficiency measurement using MRI multiplanar reconstruction with 2D assessment in the sagittal plane (MPR MRI).

Methods

We reviewed MRI images of 80 patients with anterior shoulder instability with Osirix software using MPR. Six observers with basic experience measured the glenoid, erosion edge length, and bone loss twice, with at least one-week interval between measurements. We calculated reliability and repeatability using the intra-class correlation coefficient (ICC) and minimal detectable change with 95% confidence (MDC95%).

Results

Intra and Inter-observer ICC and MDC95% for glenoid width and height were excellent (ICC 0,89-0,96). For erosion edge length and area of the glenoid were acceptable/good (ICC 0,61-0,89). Bone loss and Pico Index were associated with acceptable/good ICC (0,63 -0,86)) but poor MDC95% (45 - 84 %). Intra-observer reliability improved with time, while inter-observer remained unchanged.

Conclusion

The MPR MRI measurement of the anterior glenoid lesion is very good tool for linear parameters. This method is not valid for Pico index measurement, as the area of bone loss is variable. The pace of learning is individual, therefore complex calculations based on MPR MRI are not resistant to low experience as opposed to true 3D CT
Managing prostate cancer after proctocolectomy and ileal pouch-anal anastomosis: feasibility and outcomes of single-port transvesical robot-assisted radical prostatectomy
Authors: Pedraza Adriana M. , Ferguson Ethan L. , Ramos-Carpinteyro Roxana , Mikesell Carter , Chavali Jaya S. , Soputro Nicolas , Almassi Nima , Weight Christopher , Gorgun Emre , Kaouk Jihad
Published: June 2024

Introduction

Patients with proctocolectomy and ileal pouch-anal anastomosis (PC-IPAA) face unique challenges in managing prostate cancer due to their hostile abdomens and heightened small bowel mucosa radiosensitivity. In such cases, external beam radiation therapy (EBRT) is contraindicated, and while brachytherapy provides a safer option, its oncologic effectiveness is limited. The Single-Port Transvesical Robot-Assisted Radical Prostatectomy (SP TV-RARP) offers promise by avoiding the peritoneal cavity. Our study aims to evaluate its feasibility and outcomes in patients with PC-IPAA.

Methods

A retrospective evaluation was done on patients with PC-IPAA who had undergone SP TV-RARP from June 2020 to June 2023 at a high-volume center. Outcomes and clinicopathologic variables were analyzed.

Results

Eighteen patients underwent SP TV-RARP without experiencing any complications. The median hospital stay was 5.7 h, with 89% of cases discharged without opioids. Foley catheters were removed in an average of 5.5 days. Immediate urinary continence was seen in 39% of the patients, rising to 76 and 86% at 6- and 12-month follow-ups. Half of the cohort had non-organ confined disease on final pathology. Two patients with ISUP GG3 and GG4 exhibited detectable PSA post-surgery and required systemic therapy; both had SVI, multifocal ECE, and large cribriform pattern. Positive surgical margins were found in 44% of cases, mostly Gleason pattern 3, unifocal, and limited. After 11.1 months of follow-up, no pouch failure or additional BCR cases were found.

Conclusion

Patients with PC-IPAA often exhibit aggressive prostate cancer features and may derive the greatest benefit from surgical interventions, particularly given that radiation therapy is contraindicated. SP TV-RARP is a safe option for this group, reducing the risk of bowel complications and promoting faster recovery.
Palliative (farewell) culture in shared housing arrangements
Authors: Walter Carola , Lex Katharina
Published: June 2024

Background

Shared housing arrangements (SHA) are alternatives to long-term care facilities for care-dependent people. The collective perspective of nursing professionals working in SHA in dealing with death and dying is missing in recent studies. This study aimed to investigate the perspective of professionals concerning a palliative (farewell) culture in SHA.

Methods

In this study two group discussions were conducted with nurses and nursing assistants working in SHA. Data were analyzed using the documentary method, with the aim of working out the professional orientation framework concerning a collective palliative culture.

Results

Nurses enable a palliative (farewell) culture. This leads to the fact that hospice services are not used in these SHA. The distance to relatives as well as a short dying process or incomplete dying support can make a successful palliative culture difficult. Depending on the conscious assumption of responsibility for a palliative culture in the nursing concept of SHA, death and dying are discussed at an early stage with the relatives and care-dependent people.

Discussion

The constantly progressing palliative culture in SHA is based on nurses’ experiences, general practitioners (GP) and relatives. The family carers’ role is ambiguous. If they do what they are supposed to do from the professional nurses’ point of view and are closely connected to the nurses, they are viewed positively and as enablers of a palliative culture. If family carers’ responsibilities are not communicated and they are not in close contact with professional nurses, they are viewed as opponents of a palliative culture. The GPs are seen as enablers of a palliative culture in both discussions. A timely discussion on what might happen in the end of life phase, formalized or not, helps all involved groups to be prepared.
Automated detection of cognitive impairment in clinical practice
Authors: Busch Robyn M. , Hogue Olivia , Postle Abagail F. , Floden Darlene P.
Published: June 2024

Objective

Cognitive impairment is now recognized as an impending public health crisis. About one-third of adults are concerned about their cognition, and the prevalence of objective cognitive impairment is much higher among those with neurological disorders. Existing screening tools are narrowly focused on detecting dementia in older adults and must be clinician-administered and scored, making them impractical for many neurology practices. This study examined the utility of a brief, self-administered, computerized cognitive screening tool, the Brief Assessment of Cognitive Health (BACH), in identifying cognitive impairment in adults.

Methods

912 adults (ages 18–84) completed BACH and a neuropsychological battery. Multivariable models were developed to provide a BACH index score reflecting the probability of cognitive impairment for individual patients. Predictive accuracy was compared to that of the Montreal Cognitive Assessment (MoCA) in a subset of 160 older adults from a Memory Disorders clinic.

Results

The final multivariable model showed good accuracy in identifying cognitively impaired individuals (c = 0·77). Compared to MoCA, BACH had superior predictive accuracy in identifying older patients with cognitive impairment (c = 0·79 vs. 0·67) as well as differentiating those with MCI or dementia from those without cognitive impairment (c = 0·86 vs. c = 0·67).

Conclusions

Results suggest that cognitive impairment can be identified in adults using a brief, self-administered, automated cognitive screening tool, and BACH provides several advantages over existing screeners: self-administered; automatic scoring; immediate results in health record; easily interpretable score; utility in wide range of patients; and flags for treatable factors that may contribute to cognitive complaints (i.e., depression, sleep problems, and stress).
Shortfalls of free autologous internal limiting membrane transplantation for highly myopic refractory macular holes in a long term follow-up
Authors: Carlà Matteo Mario , Mateo Carlos
Published: June 2024

Background

The aim of this study is to evaluate long-term anatomical and functional outcomes of autologous internal limiting membrane (ILM) transplantation in refractory highly myopic macular holes (HMMHs).

Methods

Retrospective interventional analysis of 13 eyes with refractory HMMH undergoing autologous ILM transplantation with gas tamponade. Best-corrected visual acuity (BCVA, Snellen), optical coherence tomography and fundus photography were scheduled at baseline and every follow-up visit (1, 3, 6, 12, 18, 24 months and the most recent). Preoperatively, we collected minimum linear diameter (MLD) and basal diameter (BD). Post-operatively, rates of external limiting membrane (ELM)/ellipsoid zone (EZ) restoration, excessive gliosis and subfoveal retinal pigmented epithelium (RPE) atrophy were evaluated.

Results

Average AXL was 31.45 ± 2.07 mm and mean follow-up was 47.2 ± 31.4 months. Anatomical success was reached in 7/13 eyes (54%), while 2 cases showed persisting HMMH, 2 cases had early recurrence and 2 cases late recurrence. BCVA went from 0.19 ± 0.18 to 0.22 ± 0.20 at final follow-up (p = 0.64), improving in 5/13 eyes (38%). One eye showed continuous ELM and EZ lines, while another eye showed an irregular ELM but no EZ. Post-operatively, 5 eyes (71%) developed progressive atrophy of the subfoveal RPE, while excessive gliosis was reported in 3 eyes (43%). Furthermore, one patient developed post-operative chronic macular edema-like changes in the perifoveal area.

Conclusion

Autologous ILM transplantation showed controversial anatomical outcomes and and poor visual results in refractory HMMH. Moreover, progressive subfoveal patchy atrophy and excessive gliosis are possible post-operative complications.
Small cell neuroendocrine carcinoma and poorly differentiated rhabdomyosarcomas of the urinary bladder in adults—A comparative analysis in favor of a common histogenesis
Authors: Bahlinger Veronika , Stoehr Robert , Hartmann Arndt , Hes Ondřej , Agaimy Abbas
Published: June 2024

Rhabdomyosarcoma (RMS) of the urinary bladder in adults and elderly is an exceptionally rare neoplasm that displays poorly differentiated solid (alveolar-like) small cell pattern, frequently indistinguishable from small cell neuroendocrine carcinoma (SCNEC). However, the histogenesis of RMS and SCNEC and their inter-relationship have not been well studied and remained controversial. We herein analyzed 23 SCNEC and 3 small round cell RMS of the bladder for neuroendocrine (synaptophysin + chromogranin A) and myogenic (desmin + myogenin) marker expression and for TERT promoter mutations. In addition, the RMS cohort and one SCNEC that was revised to RMS were tested for gene fusions using targeted RNA sequencing (TruSight Illumina Panel which includes FOXO1 and most of RMS-related other genes). Overall, significant expression of myogenin and desmin was observed in one of 23 original SCNEC justifying a revised diagnosis to RMS. On the other hand, diffuse expression of synaptophysin was noted in 2 of the 4 RMS, but chromogranin A was not expressed in 3 RMS tested. TERT promoter mutations were detected in 15 of 22 (68%) SCNEC and in two of three (67%) assessable RMS cases, respectively. None of the four RMS cases had gene fusions. Our data highlights phenotypic and genetic overlap between SCNEC and RMS of the urinary bladder. High frequency of TERT promoter mutations in SCNEC is in line with their presumable urothelial origin. In addition, the presence of TERT promoter mutation in 2 of 3 RMS and lack of FOXO1 and other gene fusions in all 4 RMSs suggest a mucosal (urothelial) origin, probably representing extensive monomorphic rhabdomyoblastic transdifferentiation in SCNEC.
Long-term outcomes and prognosis of neuroendocrine neoplasms of the head and neck: a cohort from a single institution
Authors: Shi Xinqi , Huang Xiaodong , Wang Kai , Qu Yuan , Chen Xuesong , Wu Runye , Zhang Ye , Zhang Jianghu , Luo Jingwei , Wang Jingbo , Yi Junlin
Published: June 2024

Background

Neuroendocrine neoplasm is a rare cancer of head and neck. This study aimed to evaluate clinical features, treatment outcomes, and prognostic factors of neuroendocrine neoplasm of head and neck treated at a single institution.

Methods

Between Nov 2000 and Nov 2021, ninety-three patients diagnosed with neuroendocrine neoplasms of head and neck treated at our institution were reviewed retrospectively. The initial treatments included chemotherapy (induction, adjuvant, or concurrent) combined with radiotherapy in 40 patients (C + RT group), surgery followed by post-operative RT in 34 (S + RT group), and surgery plus salvage therapy in 19 patients (S + Sa group).

Results

The median follow-up time was 64.5 months. 5-year overall survival rate (OS), progression-free survival rate (PFS), loco-regional relapse-free survival free rate (LRRFS) and distant metastasis-free survival rate (DMFS) were 64.5%, 51.6%, 66.6%, and 62.1%, respectively. For stage I–II, the 5-year LRRFS for patients’ treatment regimen with or without radiotherapy (C + RT and S + RT groups versus S + Sa group) was 75.0% versus 12.7% (p = 0.015) while for stage III–IV, the 5-year LRRFS was 77.8% versus 50.0% (p = 0.006). The 5-year DMFS values for patients with or without systemic therapy (C + RT group versus S + RT or S + Sa) were 71.2% and 51.5% (p = 0.075). 44 patients (47.3%) experienced treatment failure and distant metastasis was the main failure pattern.

Conclusions

Radiotherapy improved local–regional control and played an important role in the management of HNNENs. The optimal treatment regimen for HNNENs remains the combination of local and systemic treatments.
On the Dominant of the Multicut Polytope
Authors: Chimani Markus , Juhnke Martina , Nover Alexander
Published: June 2024

Given a graph $$G=(V,E)$$

G
=
(
V
,
E
)

and a set $$S \subseteq \left( {\begin{array}{c}V\\ 2\end{array}}\right) $$

S
⊆

V

2

of terminal pairs, the minimum multicut problem asks for a minimum edge set $$\delta \subseteq E$$

δ
⊆
E

such that there is no s-t-path in $$G -\delta $$

G
-
δ

for any $$\{s,t\}\in S$$

{
s
,
t
}
∈
S

. For $$|S|=1$$

|
S
|
=
1

this is the well known s-t-cut problem, but in general the minimum multicut problem is NP-complete, even if the input graph is a tree. The multicut polytope $$\textsc {MultC}^\square (G,S)$$

M

U
L
T
C

□

(
G
,
S
)

is the convex hull of all multicuts in G; the multicut dominant is given by $$\textsc {MultC}(G,S)=\textsc {MultC}^\square (G,S)+\mathbb {R}^E_{{\ge 0}}$$

M

U
L
T
C

(
G
,
S
)

=
M

U
L
T
C

□

(
G
,
S
)

+

R

≥
0

E

. The latter is the relevant object for the minimization problem. While polyhedra associated to several cut problems have been studied intensively there is only little knowledge for multicut. We investigate properties of the multicut dominant and in particular derive results on liftings of facet-defining inequalities. This yields a classification of all facet-defining path- and edge inequalities. Moreover, we investigate the effect of graph operations such as node splitting, edge subdivisions, and edge contractions on the multicut-dominant and its facet-defining inequalities. In addition, we introduce facet-defining inequalities supported on stars, trees, and cycles and show that the former two can be separated in polynomial time when the input graph is a tree.
Machine learning assisted discovery of effective viscous material laws for shear-thinning fiber suspensions
Authors: Sterr Benedikt , Hrymak Andrew , Schneider Matti , Böhlke Thomas
Published: June 2024

In this article, we combine a Fast Fourier Transform based computational approach and a supervised machine learning strategy to discover models for the anisotropic effective viscosity of shear-thinning fiber suspensions. Using the Fast Fourier Transform based computational approach, we study the effects of the fiber orientation state and the imposed macroscopic shear rate tensor on the effective viscosity for a broad range of shear rates of engineering process interest. We visualize the effective viscosity in three dimensions and find that the anisotropy of the effective viscosity and its shear rate dependence vary strongly with the fiber orientation state. Combining the results of this work with insights from literature, we formulate four requirements a model of the effective viscosity should satisfy for shear-thinning fiber suspensions with a Cross-type matrix fluid. Furthermore, we introduce four model candidates with differing numbers of parameters and different theoretical motivations, and use supervised machine learning techniques for non-convex optimization to identify parameter sets for the model candidates. By doing so, we leverage the flexibility of automatic differentiation and the robustness of gradient based, supervised machine learning. Finally, we identify the most suitable model by comparing the prediction accuracy of the model candidates on the fiber orientation triangle, and find that multiple models predict the anisotropic shear-thinning behavior to engineering accuracy over a broad range of shear rates.
A general-purpose IGA mesh generation method: NURBS Surface-to-Volume Guided Mesh Generation
Authors: Kuraishi Takashi , Takizawa Kenji , Tezduyar Tayfun E.
Published: June 2024

The NURBS Surface-to-Volume Guided Mesh Generation (NSVGMG) is a general-purpose mesh generation method, introduced to increase the scope of isogeometric analysis in computing complex-geometry problems. In the NSVGMG, NURBS patch surface meshes serve as guides in generating the patch volume meshes. The interior control points are determined independent of each other, with only a small subset of the surface control points playing a role in determining each interior point. In the updated version of the NSVGMG we are introducing in this article, in the process of determining the location of an interior point in a parametric direction, more weight is given to the closer guides, with the closeness measured along the guides in the other parametric directions. Tests with 2D and 3D shapes show the effectiveness of the NSVGMG in generating good quality meshes, and the robustness of the updated NSVGMG even in mesh generation for complex shapes with distorted boundaries.
Artificial neural network evaluation of concrete performance exposed to elevated temperature with destructive–non-destructive tests
Authors: Demir Tuba , Duranay Zeynep Bala , Demirel Bahar , Yildirim Busra
Published: June 2024

In this study, it is aimed to predict the performance of concretes obtained by using supplementary cementitious materials (SCM) before and after high temperature using artificial neural network. Thus, in addition to contributing to sustainable development and circular economy by using waste materials in concrete production, predicting concrete strength using artificial neural network without the need for experimental studies will provide a great advantage in practice. In addition, it will also contribute to the literature in terms of determining the optimum amount of metakaolin to be used with fly ash in concrete production. Metakaolin, silica fume and fly ash were used as SCM in different proportions in concrete mixes. Accordingly, a total of 22 concrete series were prepared, one of which was the control series. Porosity, ultrasonic pulse velocity, pressure and tensile strength tests were applied to the series at the end of 7th, 28th and 90th curing periods before high temperature. In order to determine the strength losses after elevated temperature, porosity and compressive strength tests were applied at temperatures of 400, 600 and 800 °C. Mineral additive series showed positive mechanical properties up to 20%. However, it has been observed that the use of fly ash after a certain rate causes a decrease in strength. After elevated temperature, strength loss was observed in all series due to the increase in temperature, while it was observed that the rate of being affected by elevated temperature decreased as the percentage of metakaolin increased. Optimum mineral additive usage percentages were determined as 10% fly ash and 15% metakaolin. On the other hand, the use of mineral additives above the optimum level caused the performance of the concrete to decrease. Then, the concrete compression strengths obtained at 7th, 28th, and 90th days and at 400, 600 and 800 °C temperatures are taken as the outputs of the ANN. The artificial neural network provided the closest results to experimental data. Moreover, to prove the predictive performance of ANN, a comparative analysis was made with GPR, SVM and LR and the smallest value of the RMSE value is obtained with the ANN model. Finally, a fivefold cross-validation criteria was used to objectively present the performance of the model.
Fluctuations and failure in granular materials: theory and numerical simulations
Authors: La Ragione Luigi , Recchia Giuseppina , Darve Felix , Nicot Francois , Wautier Antoine
Published: June 2024

We consider a dense aggregate of elastic, frictional particles isotropically compressed and next uniaxial strained at constant pressure. We show how failure can be predicted if fluctuations in the kinematics of contacting particles are introduced. We focus on the second order work and the possibility that at some stressed states it becomes negative under proper perturbations. Our analysis involves both a theoretical model and numerical simulations based upon the distinct element method (DEM). The theoretical model deals with contacting particles with incremental relative displacements that deviate from the average deformation in order to ensure their equilibrium. Because of this, the macroscopic stiffness tensor of the aggregate, that relates increments in stress with increments in strain, does not have the major symmetry. Consequently, in the hardening regime, we predict stressed states in which the second order work vanishes. The model seems transparent, and it makes clear and illustrative the role played by the fluctuations introduced in the kinematics of contacting particles in relation to the vanishing of second order work in an aggregate of compressed particles. The comparison with numerical simulations data supports the model.

Graphical Abstract

Statistical representation of the aggregate: conditional average.
Are lateralized and bold fish optimistic or pessimistic?
Authors: Berlinghieri F. , Rizzuto G. , Kruizinga L. , Riedstra B. , Groothuis TGG. , Brown C.
Published: June 2024

Cognitive bias is defined as the influence of emotions on cognitive processes. The concept of the cognitive judgement bias has its origins in human psychology but has been applied to animals over the past 2 decades. In this study we were interested in determining if laterality and personality traits, which are known to influence learning style, might also be correlated with a cognitive bias in the three-spined sticklebacks (Gasterosteus aculeatus). We used the judgement bias test with the go/no-go procedure where fish were first trained to discriminate between a black and white card and, after reaching a minimum learning criterion, tested their response to an ambiguous card (grey). Optimistic subjects were expected to have a high expectation of reward associated with an ambiguous stimulus, whereas pessimistic subjects a high expectation of non-reward. We used an emergence and a mirror test to quantify boldness and laterality, respectively. We hypothesised that male, bolder and more strongly lateralized fish would be more optimistic than female, shy and less strongly lateralised fish. We found that males and more strongly lateralized fish were more optimistic than females and less strongly lateralized fish. In addition, bold males were more optimistic than shy males as we predicted, but females showed the opposite pattern. Finally, fish trained on the black colour card learned the training task faster than those trained on a white card. Our results indicate that both laterality and personality traits are linked to animals’ internal states (pessimistic or optimistic outlooks) which likely has broad implications for understanding animal behaviour particularly in a welfare context.
Two Decades of Publications in Journals Dedicated to Autoimmunity: A Bibliometric Analysis of the Autoimmunity Field from 2004 to 2023
Authors: Tao Sha-Sha , Tang Jian , Yang Xiao-Ke , Fang Xi , Luo Qing-Qing , Xu Yi-Qing , Ge Man , Ye Fan , Wang Peng , Pan Hai-Feng
Published: June 2024

To carry out an in-depth analysis of the scientific research on autoimmunity, we performed the first bibliometric analysis focusing on publications in journals dedicated to autoimmunity (JDTA) indexed by science citation index during the period 2004–2023. Using bibliometric analysis, we quantitatively and qualitatively analyzed the country, institution, author, reference and keywords information of publications in JDTA, so as to understand the quantity, publication pattern and publication characteristics of these publications. The co-occurrence networks, clustering map and timeline map were created by CiteSpace and VOSviewer software to visualize the results. The CiteSpace was also used to analyze the strongest citation burst of keywords, which could describe the frequency, intensity and time period of high-frequency keywords, and indicate the research hotspots in the field. A total of 5 710 publications were analyzed, and their annual distribution number was basically stable from 2004 to 2023, fluctuating around 300. The United States and Italy led the way in terms of the number of publications, followed by France and China. For international cooperation, the developed countries represented by the United States cooperate more closely, but the cooperation was localized, reflecting that there was no unified model of autoimmunity among countries. UDICE-French Research Universities had the greatest number of publications. Subsequently, the number of publications decreased slowly with the ranking, and the gradient was not large. Eric Gershwin and Yehuda Shoenfeld stood out among the authors. They had an excellent academic reputation and great influence in the field of autoimmunity. The results of keyword analysis showed that JDTA publications mainly studied a variety of autoimmune diseases, especially SLE and RA. At the same time, JDTA publications also paid special attention to the research of cell function, autoantibody expression, animal experiments, disease activity, pathogenesis and treatment. This study is the first to analyze the publications in JDTA from multiple indicators by bibliometrics, thus providing new insights into the research hotspots and development trends in the field of autoimmunity.
Projection free methods on product domains
Authors: Bomze Immanuel , Rinaldi Francesco , Zeffiro Damiano
Published: June 2024

Projection-free block-coordinate methods avoid high computational cost per iteration, and at the same time exploit the particular problem structure of product domains. Frank–Wolfe-like approaches rank among the most popular ones of this type. However, as observed in the literature, there was a gap between the classical Frank–Wolfe theory and the block-coordinate case, with no guarantees of linear convergence rates even for strongly convex objectives in the latter. Moreover, most of previous research concentrated on convex objectives. This study now deals also with the non-convex case and reduces above-mentioned theory gap, in combining a new, fully developed convergence theory with novel active set identification results which ensure that inherent sparsity of solutions can be exploited in an efficient way. Preliminary numerical experiments seem to justify our approach and also show promising results for obtaining global solutions in the non-convex case.
The Effects of Contextual Interference Learning on the Acquisition and Relatively Permanent Gains in Skilled Performance: A Critical Systematic Review with Multilevel Meta-Analysis
Authors: Ammar Achraf , Trabelsi Khaled , Boujelbane Mohamed Ali , Salem Atef , Boukhris Omar , Glenn Jordan M. , Zmijewski Piotr , Jahrami Haitham A. , Chtourou Hamdi , Schöllhorn Wolfgang I.
Published: June 2024

The paradoxical effects of contextual interference (CI) assume that high CI practices hinder performances during the acquisition phase of learning, while providing more permanent enhancement during the retention phase. This meta-analysis evaluates the possible generalizability of the CI phenomenon in physical education (PE) and sports contexts, with regard to the acute and relatively permanent gains in performance outcomes. A total of 933 records from five electronic databases were screened using the PICOS criteria, of which 36 studies were selected. Outcomes evaluating the performance changes (Δ) from pre-post, post-retention, and pre-retention tests were included. Out of 183 overall pooled outcomes, Δ in only 37 performance outcomes (20%) agreed with the paradoxical CI effects on the acquisition or the relatively permanent gains. No statistically significant overall difference was detected for “Δ pre-post” between low (blocked) (28.9 ± 59.5%) and high (random/serial) (27.9 ± 52.8%) CI (effect size (ES) = 0.1, p = 0.35). An overall significant difference (p = 0.001) in favor of high CI practice was detected in “Δ post-retention.” However, this difference was not large enough (ES =  − 0.35) to produce an overall greater long-term gain following high (24.56 ± 4.4%), compared to low (21.9 ± 9.8%) CI (ES =  − 0.13, p = 0.18). Out of 10 tested variables, only the age significantly moderated both CI effects (p < 0.0001 for both Δ pre-post and Δ pre-retention) and the female proportion significantly moderated only the first CI effect (p = 0.009 for Δ pre-post). These findings found very limited evidence supporting the recommendation to employ high CI practices to gain a longer-term performance advantage, calling into question the generalization of the CI model to PE and sports practices. High-quality follow-up research evaluating alternative motor-learning models are therefore needed.