bluuebunny/crossref_metadata_2025 huggingface dataset:
Vergleich des immunologischen Phänotyps der chronisch-entzündlichen Dermatosen Acne inversa, Sinus pilonidalis und Perifolliculitis capitis abscedens et suffodiens
Authors:   , Außner Sonja
Published: August 2023

Chronisch-entzündliche Dermatosen sind in Deutschland weit verbreitet und haben einen enormen Einfluss auf die Lebensqualität der Erkrankten. Das umfassende Verständnis der molekularen Prozesse und Signalwege bildet die Basis, um mögliche Beziehungen zwischen den Hauterkrankungen aufzudecken. Der Nachweis von Ähnlichkeit und Übereinstimmung in den Signalwegen bietet die Aussicht, dass etablierte Therapien auch bei anderen Erkrankungen helfen können. Der Zweck dieser Arbeit ist der Nachweis der Expression von IL-1β, IL-17A, IL-22, IL-23 und TNF-α in drei chronisch-entzündlichen Dermatosen: Acne inversa (AI), Sinus pilondalis (SP) und Perifolliculitis capitis abscedens et suffodiens (PCAS). Bei allen untersuchten Diagnosen handelt es sich um potentiell verwandte Erkrankungen der Haarfollikel, die durch Verlegung der Ausführungsgänge zu ausgedehnten Entzündungsreaktionen mit Bildung von Knoten, Abszessen und Fisteln führen. Bereits nachgewiesen ist, dass IL-1β, IL-17A, IL-22, IL-23 und TNF-α eine wichtige Rolle in der Pathogenese von Acne inversa spielen und Antikörpertherapien an einigen dieser Zielproteine spezifisch angreifen, um den Verlauf der Erkrankung zu verbessern. Die Expression der Proteine wurde in Läsionen von Patienten mit den drei Indikationen immunhistochemisch an paraffiniertem Gewebe untersucht. Wie erwartet, zeigten sich in der überwiegenden Anzahl der Proben große entzündliche Infiltrate und hier wurde die Expression aller untersuchten Zytokine in unterschiedlicher Intensität nachgewiesen. Vielversprechend war insbesondere die Expression von IL-17A und IL-23 in SP und PCAS. Die Expression von IL-1β war insgesamt eher gering ausgeprägt; bei AI noch etwas höher als in SP und PCAS. Die Färbungen auf IL-22 zeigten sich kräftig in allen untersuchten Dermatosen. Allerdings gibt es bisher keine zugelassene Therapie zur Modulation dieses speziellen Zytokins. IL-22 scheint eine zentrale Rolle in der Pathogenese der AI zu spielen. Mit TNF-α-Blockern wurden schon gute therapeutische Ergebnisse bei AI und PCAS erzielt. Deshalb ist der Nachweis von TNF-α in den entzündlichen Läsionen zu erwarten gewesen. Auch bei den SP-Proben fanden sich deutlich erhöhte Protein-Level, sodass auch hier eine gezielte Therapie von Vorteil sein könnte. Wegen des geringen Probenumfangs und der Methodik sind weitere gezielte Untersuchungen notwendig. Dennoch konnten viele Gemeinsamkeiten der Zytokinexpression ausgemacht werden, was vielversprechende Hinweise auf mögliche Behandlungsansätze bei AI, SP und PCAS zulässt. Diese Arbeit bietet einen ersten Blick auf den immunologischen Phänotyp der verwandten Dermatosen.
Vírus da Hepatite B e Câncer Bucal: Existe Alguma Relação?
Authors: Andrade Araujo Amanda do Perpetuo Socorro , Cabral Lioney Nobre , Pinheiro Tiago Novaes , Vasconcellos II Antonio Jorge de Araujo
Published: August 2023

Dentre as neoplasias malignas da cavidade oral, o carcinoma espinocelular (CEC) é a mais comum delas e embora seja um evento raro, pode se originar a partir de lesões cancerizáveis, como o líquen plano oral (LPO) e lesões liquenóides (LL). Tais lesões, assim como o CEC estão possivelmente associadas ao vírus da hepatite C (VHC). Sabe-se que o vírus da hepatite B (VHB) está intimamente ligado ao desenvolvimento do carcinoma hepatocelular, no entanto são escassos os estudos sobre os fenômenos do vírus sobre o epitélio oral. Em razão dos resultados de pesquisas sobre a cancerização dessas lesões serem variáveis e não consensuais, considera-se a existência de outros possíveis fatores de risco ainda não explorados pela ciência. O presente trabalho relata caso de paciente do sexo masculino, 67 anos, com sorologia positiva para VHB e histórico de tabagismo e etilismo, abstêmio há 2 e 10 anos, respectivamente, queixando-se de lesão nodular em soalho bucal e com diagnóstico anterior de lesão liquenóide, que foi tratada com corticoide tópico e cessão do tabagismo e do uso das próteses totais. Ao exame intraoral foi identificada lesão exofítica extensa em soalho bucal, que submetida a biópsia incisional, teve diagnóstico de carcinoma espinocelular basaloide (CEB), uma variante histológica rara do CEC. O paciente foi submetido a tratamento cirúrgico, radio e quimioterápico. Consideramos que a infecção crônica pelo VHB, poderia constituir um fator de risco para a cancerização do LPO e LL através dos efeitos que produtos da replicação viral têm sobre a regulação da proliferação celular.
An Empirical Approach in Culinary Fiqh of Coastal Communities: Critical Study of ‘Aysh al-Baḥr
Authors: Mun'im Zainul , Kaya Abdussamet
Published: August 2023

The lives of fishermen are said to have a profound influence on the lives of coastal towns. Their attitude toward marine resources effects their theological perspective as well. This fact is supported by Kiai Anwar's book ‘Aysh al-Baḥr, which discusses the legal position of consuming numerous aquatic animals. This article seeks to trace the book ‘Aysh al-Baḥr's understanding of culinary fiqh. As an analytical tool, this paper employs a normative approach and the notion of Islamic epistemology pioneered by al-Jābirī and Mulyadhi. This article demonstrates how the epistemology of culinary fiqh in ‘Aysh al-Baḥr employs an empirical approach to determining the legal status of ingesting animals by viewing and direct observing them. Kiai Anwar's background as a fisherman gives him an edge in developing normative and empirical reasons for marine animal laws. This conclusion demonstrates that coastal cultures have an extensive understanding of aquatic animal environments. This article suggests utilizing empirical approaches to derive rules that necessitate direct observation.__________The original draft of this article has been presented at the 20th Annual International Conference on Islamic Studies (AICIS), Surakarta, 2021.
Childfree in Islamic Law Perspective of Nahdlatul Ulama
Authors: Syafi'i Imam , Hamidah Tutik , Yasin Noer , Muhammad Umar
Published: August 2023

Childfree is a social phenomenon that is becoming an interesting discussion today. It deserves the attention of Islamic law. Nahdlatul Ulama (NU), through the NU Bahtsul Masail Institute (LBM-NU), has issued four fatwas synonymous with the childfree phenomenon. This article aims to analyze the childfree phenomenon from the perspective of the istinbāṭ al-aḥkām method used by NU and its relevance to the four fatwas. This article is qualitative research using a normative Islamic law approach, which examines NU’s legal decisions regarding the denial of childbirth. These decisions are then analyzed to determine the meaning and method of istinbāṭ used. This article finds two things. First, the istinbāṭ al-aḥkām method used by LBM-NU is the qawlī intiqādī method. Second, from the aspect of its application, childfree can be equated in law with decisions that have been determined by LBMNU regarding child refusal, as long as the method adopted is legal. However, from the aspect of substance, where childfree is used as a principle and lifestyle, it requires a new fatwā decision, especially with the manhajī approach.
Al-Khurūj ‘alā al-Ḥākim fī al-Fiqh al-Siyāsī al-Islāmī: Dirāsah ‘alā Ma’nā al-Thawrah
Authors: Hadi Taufiqul , Masrukhin Mohammad Yunus , Masruri Siswanto , Burdah Ibnu
Published: August 2023

The Arab Spring emerged due to a political crisis in most Arab countries that wanted a change from dictatorial regimes to democratic systems in their countries. One of the most prominent issues that caused controversy during the revolution was the issue of al-khurūj 'alā al-ḥākim. This article aims to analyze the meaning of revolution from an Islamic political perspective by discussing the concept of al-khurūj 'alā al-ḥākim, especially towards the three terms: al-bāghī, al-khawārij and al-ḥirābah. This article clarifies the relationship between these three terms with the phenomenon of revolution in the contemporary Islamic world. This article uses a jurisprudential approach with an inductive method by extrapolating jurisprudential sources and references related to the research subject. This article concludes that the notion of revolution is not the same as the concept of al-khurūj 'alā al-ḥākim in Islamic jurisprudence. The reason is that revolution aims to change the political, social and economic reality. In contrast, khurūj is a form of resistance to the leader and does not carry out all the rights demanded of the ruler. In the present context, the redefinition of the concept of al-khurūj 'alā al-ḥākim in Islamic jurisprudence is necessary to suit the modern era.
Six-DOF modular robotic arm bearing chatter suppression algorithm
Authors: Zheng Man , Jin Jun
Published: August 2023

Robotic arms are frequently utilized in contemporary industrial production since they offer great qualities like high precision and low mass. How to minimize robotic arm tremors in order to maximize their control effect has emerged as one of the most critical issues to be resolved with the continued development of industrial intelligence. The study uses a combination of PID control and an artificial fish swarm technique to optimize the parameters and confirm the simulation control effect based on the kinematic analysis of a six-degree-of-freedom (Six-DOF) modular robotic arm. The findings demonstrated that the suggested fusion approach converges to zero in 80 iterations and has a recall of 0.893 and 0.785 at an accuracy of 0.8 and 0.9, respectively. The robotic arm control system’s average control effect is 42.96 %, which is a respectable control performance. In the second and third studies, the fusion approach stabilized actuator end tremor suppression after 0.01 s and 0.0001 s, respectively. It shows that the technique can effectively suppress robotic arm bearing tremor and has high flexibility for robotic arm tremor suppression, which offers trustworthy technological support for improving the motion control system of industrial robots.
Agricultural wetland utilization based on land cover restoration and water–ecosystem nexus
Authors: Li Jing , Liu Weiwei , Zhang Ying
Published: August 2023

Wetlands, as a special ecological environment, are not only important biodiversity conservation areas but also one of the important agricultural resources. Agriculture plays an irreplaceable role in human society. It is directly related to human survival and development, and is also a part of people's environmental awareness and cultural inheritance. Based on the principles of sustainable development and strengthening environmental protection, people should pay more attention to the development and improvement of agriculture. However, with the advancement of urbanization, the area of wetlands continues to decrease, causing damage to ecosystems and posing a threat to some agricultural production. This article combined the transfer matrix of agricultural wetland utilization, landscape change rate, and landscape pattern index, used RS (Remote Sensing) and GIS (Geographic Information System) technologies to analyze the dynamic changes in agricultural wetland utilization and landscape of Honghu Lake in the Four Lakes region, and explored its changing factors. The results indicated that the construction land area showed an increasing trend in 2016, 2019, and 2022, while the wetland area of rice fields showed a first decreasing and then increasing trend.
Medicinal (Radio) Chemistry: Building Radiopharmaceuticals for the
Future
Authors: Pijeira Martha Sahylí Ortega , Nunes Paulo Sérgio Gonçalves , Chaviano Samila Leon , Diaz Aida M. Abreu , DaSilva Jean N. , Ricci-Junior Eduardo , Alencar Luciana Magalhães Rebelo , Chen Xiaoyuan , Santos-Oliveira Ralph
Published: August 2023

:

Radiopharmaceuticals are increasingly playing a leading role in diagnosing,
monitoring, and treating disease. In comparison with conventional pharmaceuticals, the
development of radiopharmaceuticals does follow the principles of medicinal chemistry
in the context of imaging-altered physiological processes. The design of a novel radiopharmaceutical
has several steps similar to conventional drug discovery and some particularity.
In the present work, we revisited the insights of medicinal chemistry in the current
radiopharmaceutical development giving examples in oncology, neurology, and cardiology.
In this regard, we overviewed the literature on radiopharmaceutical development to
study overexpressed targets such as prostate-specific membrane antigen and fibroblast activation
protein in cancer; β-amyloid plaques and tau protein in brain disorders; and angiotensin
II type 1 receptor in cardiac disease. The work addresses concepts in the field
of radiopharmacy with a special focus on the potential use of radiopharmaceuticals for
nuclear imaging and theranostics.
Association of Neurokinin-1 Receptor Signaling Pathways with Cancer
Authors: Rodriguez Francisco David , Covenas Rafael
Published: August 2023

Background:

Numerous biochemical reactions leading to altered cell proliferation
cause tumorigenesis and cancer treatment resistance. The mechanisms implicated include
genetic and epigenetic changes, modified intracellular signaling, and failure of control
mechanisms caused by intrinsic and extrinsic factors alone or combined. No unique
biochemical events are responsible; entangled molecular reactions conduct the resident
cells in a tissue to display uncontrolled growth and abnormal migration. Copious experimental
research supports the etiological responsibility of NK-1R (neurokinin-1 receptor)
activation, alone or cooperating with other mechanisms, in cancer appearance in different
tissues. Consequently, a profound study of this receptor system in the context of malignant
processes is essential to design new treatments targeting NK-1R-deviated activity.

Methods:

This study reviews and discusses recent literature that analyzes the main signaling
pathways influenced by the activation of neurokinin 1 full and truncated receptor
variants. Also, the involvement of NK-1R in cancer development is discussed.

Conclusion:

NK-1R can signal through numerous pathways and cross-talk with other receptor
systems. The participation of override or malfunctioning NK-1R in malignant processes
needs a more precise definition in different types of cancers to apply satisfactory
and effective treatments. A long way has already been traveled: the current disposal of selective
and effective NK-1R antagonists and the capacity to develop new drugs with biased
agonistic properties based on the receptor's structural states with functional significance
opens immediate research action and clinical application.
A Comprehensive Review on Therapeutic Potential of a Natural
Anthraquinone Derivative Emodin in Brain-related Disorders
Authors: Goyal Ahsas , Murti Yogesh , Bhushan Bharat , Chisti Wasim , Solanki Ashutosh
Published: August 2023

Brain-related disorders are one of the world’s most important and complex health
problems today. These brain-related disorders are responsible for a massive number of morbidities
and death all around the world. However, researchers have devoted a large amount of time to investigating
these diseases and found positive results; nevertheless, there are currently quite a few
medications available to treat them. Emodin (EM), a polyphenol compound, has many health benefits.
It is a biologically active monomer derived from rhubarb root that exhibits anti-inflammation,
anti-oxidation, anticancer, and neuroprotective properties. A series of preclinical trials have shown
EM to have protective benefits against many brain-related diseases. This review has evaluated the
potential of EM as a pharmacological agent for the treatment and management of various brain-related
disorders based on the findings of multiple pre-clinical studies and taking into account the
compound’s therapeutic properties.
Literature-based Comparative Study between Herbal and Synthetic Mucolytics
Authors: Bhuyan Pallabi , Chakraborty Tapash , Ahmed Rakib , Ali Nurul , Ghose Shatabdi
Published: August 2023

Coughing and sneezing are the body’s reflexes to various acute and chronic respiratory
illnesses like asthma, COPD, lung cancer, etc.

:

Mucus is a sticky, gelatinous material produced by the mucus gland to protect the airways. Mucolytics,
antitussives and expectorants may help in treating hypersecretion of mucin that may lead to
cough, cystic fibrosis, asthma, and COPD. Mucolytics if given along with the drugs like corticosteroids,
albuterol sulphate, and levalbuterol HCl in asthma and for the management of COPD like
corticosteroids and bronchodilators, may help in loosening the viscosity of the mucus and clearing it
out.

:

Mucolytics can be synthetic or herbal in origin and work by one of the three processes, viz. enzymatic
degradation, disulphide bond cleavage and calcium chelation. Mucolytics breaks down mucin
structure and loosen the mucus, helping it to expel out from the body. Some examples of synthetic
mucolytics are Bromhexine and N-acetylcysteine. Herbal mucolytics have traditionally been used
for the treatment of cough by indigenous people of India. Malva sylvestris, Zizyphus vulgaris are
some of the examples of herbal mucolytics.
Nutrition Role in Maintaining Health and Preventing Disease
Authors: Singh Chander , Arti  , Yadav Nikita , Rao Komal , Bharti  , Bansal Nidhi , Archna K.M.
Published: August 2023

A person's body depends on nutrients, which are the components of food that drive
biological activity. A healthy lifestyle includes having a good diet. All that we eat and drink is what
human bodies are made of and how they are powered. Proteins, lipids, carbs (sugars, dietary filter),
vitamins, and minerals are the several categories that they belong to nutrients, and each one of these
performs a crucial job. Building all body parts, including muscle, bone, teeth, and blood.
Generating energy and maintaining the body's functionality. A complete condition of emotional and
physical well-being is referred to as being "healthy." Optimal nutrition, which supplies all nutrients
at sufficient and suitable levels, is the cornerstone of good health and the forerunner of prevention.
The most significant ongoing environmental influences influencing our growth, development,
functional abilities, and health are the meals we eat and the nutrients they should include. If we
want to successfully reduce the excessive premature morbidity and death from our top killer
diseases-heart disease, cancer, and stroke-we must educate the general population, especially health
professionals, about nutrition. Our lifestyle choices, such as eating, disciplining our health habits,
and exercising, will significantly impact our individual health and lower the costs of our existing
catastrophic medical treatment. The main environmental factors that continue to impact our ability
to grow and develop health are the meals we eat and the nutrients they should include. In this
review, we discuss how nutrients play an important role in preventing our body from disease and
maintaining health.
The Effects of Vitamin D Supplementation on Glycemic Indices, Lipid
Profile and Blood Pressure of Pregnant Women with Vitamin D Deficiency:
A Single Arm Clinical Trial
Authors: Hashemi Seyedeh Razieh , Esmailzadeh Arezoo , Hosseini Mahboobeh Sadat , Abbaszadeh Sepideh , Taghdir Maryam , Esmailzadeh Simindokht , Babashamsi Tahereh , Nahani Saeideh
Published: August 2023

Introduction:

Vitamin D Deficiency (VDD) is a global problem among pregnant women in
many populations. There is an association between VDD and some pregnancy outcomes, as well as
gestational diabetes mellitus (GDM) and pre-eclampsia. We aimed to evaluate the effect of vitamin D
supplementation on metabolic status (Fasting Blood Sugar (FBS), insulin, Homeostasis model of assessment-insulin resistance (HOMA-IR) and lipid profile) and blood pressure (BP) among pregnant
women with VDD.

Methods:

A clinical trial was carried out on 30 pregnant women with VDD referring to the Gynecology & Obstetrics Clinic of Baqiyatallah Hospital, Tehran, Iran. The present study had two phases of
vitamin D3 supplementation (50000 IU / week for 12 weeks and then 50000 IU / month for three
months). Serum total cholesterol, triglyceride, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), 25-hydroxyvitamin D (25(OH) D) level, insulin, Fasting Blood Sugar (FBS) and both
systolic and diastolic blood pressure were measured. Homeostasis model of assessment-insulin resistance (HOMA-IR) was also determined.

Results:

The results showed that mean levels of Insulin (p=0.010), HOMA-IR (p=0.020), 25(OH) D
level (p=0.001), cholesterol (p=0.001), triglyceride (p=0.001) and LDL (p=0.001) significantly increases during study period. However, Diastolic and systolic blood pressure, FBS, and HDL levels did
not change significantly over time.

Conclusion:

The results of this investigation showed that weekly and monthly vitamin D3 supplementation in pregnant women with VDD had beneficial effects on glycemic status, lipid profile and blood
pressure.
Analysing the Quality of Food Using Convolution Neural Network and Fuzzy Classifier in Hyperspectral Imagery
Authors: Devi T. Arumuga Maria , Darwin.P  , Jose Mebin , Kumar P.
Published: August 2023

Introduction:

This study introduces a novel evaluation approach by combining a convolutional neural network (CNN) with a fuzzy neural network (FNN). This approach by utilizing the fuzzy neural network with a few connected layers has the capability to incorporate feature information, thus enhancing the overall functionality of the neural network. In this approach, the CNN generates feature maps (also referred to as outputs) that represent membership values. These feature maps are then input into the fuzzy layers during the training phase. This integration of feature maps and fuzzy layers enables the network to work with both crisp and fuzzy values, due to the additional information generated within the fuzzy set. As a result, an improvement in the classification accuracy of this innovative approach is reported as compared to traditional methods. By utilizing fuzzy neural networks, which can process both crisp and fuzzy values, this approach capitalizes on the expanded information provided by fuzzy sets.

Methods:

In our proposed model, cross-validation tests were conducted. However, the effectiveness of our model relies on having a larger dataset for training sequences. Currently, our dataset is limited in size. During testing, we used a dataset with a greater amount of information, which helps reveal the model's capability to classify objects. This is particularly important when dealing with cases where crucial information is missing.

Results:

The convolution neural network consists of a tuned convolution layer, heuristic activation operation, and parallel element merge layer, which is manipulated by the fuzzy classifier output based on the food image context extractor.

Conclusion:

In this study, the food quality was analyzed through visual IDE. Furthermore, the hyperspectral output image was also extracted with good accuracy.
Mycotoxins and Amyotrophic Lateral Sclerosis: Food Exposure,
Nutritional Implications and Dietary Solutions
Authors: Manera Umberto , Matteoni Enrico , Canosa Antonio , Callegaro Stefano , Casale Federico , Marchis Daniela , Vasta Rosario , Moglia Cristina , Chiò Adriano , Calvo Andrea
Published: August 2023

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder determined by a combination
of both genetic and environmental factors. Despite wide investigations, the role of chronic
exposure to environmental pollutants is still rather unknown. Among natural toxins, the mycotoxins
have received major attention only in the last few years, due to both technical and scientific achievements
that allowed to disentangle many important features of the complex fungal biology. Whereas
the effects of acute and high-dose mycotoxin exposure are well known, the potential effects of chronic
and low-dose exposure on neurodegeneration have not been broadly elucidated. In this review, we
have summarized all the studies concerning environmental exposure to unknown substances that
caused ALS outbreaks all over the world, reinterpreting in light of the new scientific acquisitions and
highlighting the potential and neglected role of mycotoxins. Then, we focused on recent papers about
food exposure to mycotoxin, mycobiome and fungal infections in ALS and other neurodegenerative
diseases. We analyzed the gaps of current literature that lead to an undervaluation of mycotoxins as
detrimental molecules. By listing all the most important mycotoxins and analyzing all the biological
pathways that they can affect, we explained the reasons why they need to be considered in the next epidemiological
studies on ALS and other neurodegenerative and neuroinflammatory diseases. In conclusion,
after suggesting some possible solutions to mitigate mycotoxin exposure risk, we affirm that
future collaborations between scientists and policymakers are important to develop sustainable interventions
and promote health through dietary diversity.
Potentials of Stem Cell Therapy in Patients Infected with COVID-
19: A Systematic Review
Authors: Tamis Zahra , Sadeghi Fatemeh , Heydari Aigin , Mirza Saima Shahzad , Morowvat Mohammad Hossein
Published: August 2023

Introduction:

In the present study, we have examined different aspects and potentials
of stem cells for the management of patients infected with COVID-19.

Background:

The novel coronavirus disease (COVID-19) has been reported in most of the
countries and territories (>230) of the world with ∼686 million confirmed cases (as of Apr.
22, 2023). While the scientific community is working to develop vaccines and develop
drugs against the COVID-19 pandemic, novel alternative therapies may reduce the mortality
rate. Recently, the application of stem cells for critically ill COVID-19 patients in a
small group of patients has been examined.

Methods:

We searched PubMed, Web of Science, and Google Scholar up to July 2022.
Those studies that reviewed COVID-19 and cell therapy potentials were entered into the
study. Moreover, some recently published patents were exploited and reviewed. Patentscope,
USPTO, Espacenet, Free Patents Online, and Google Patents were used for patent
searches.

Results:

Cell-based therapy as a modality of regenerative medicine is considered one of
the most promising disciplines in the fields of modern science and medicine. Such an advanced
technology offers endless possibilities for transformative and potentially curative
treatments for some of the most life-threatening diseases. This therapeutic tool can be useful
to reduce the rate of mortality. There have been several published patents for different
stem cell therapy platforms in recent years.

Conclusion:

Stem cell therapy could be considered a safe and effective therapeutic strategy
to reduce death cases in patients infected with COVID-19. Besides, stem cell therapy
might increase the pulmonary functions in the patients, it suppresses the occurring inflammations
and ameliorates the symptoms.
Expression and clinical significance of Cat B and sICAM-1 in the GCF of patients with peri-implantitis
Authors: Wang Qinglian , Lin Jichao , Lin Yanjun , Yu Youcheng
Published: August 2023

Background:

Peri-implantitis is an irreversible disease occurring in the tissues surrounding dental implants, and it is characterized by decreased osseointegration, progressive bone loss, bone resorption, and increased pocket formation and purulence.

Objective:

This study was conducted to elucidate the expression and clinical significance of Cat B and sICAM-1 in the gingival crevicular fluid (GCF) of patients with peri-implantitis.

Methods:

A total of 154 patients, who underwent implant denture treatment in our hospital, were selected as the research subjects. They were divided into a peri-implantitis group (65 cases) and a healthy implant group (89 cases) according to whether there was inflammation around the implant. All subjects were assessed for periodontal clinical indicators (plaque index (PLI), probing depth (PD), clinical attachment level (CAL), and sulcus bleeding index (SBI)). The levels of inflammatory factors (IL-1β, TNF-α, and IL-6) and Cat B and sICAM-1 in the GCF were measured using an enzyme-linked immunosorbent assay. Pearson test was used to analyze the correlation between the levels of Cat B and sICAM-1 in GCF and PD, SBI, CAL, PLI, IL-1β, TNF-α, and IL-6. ROC curve was used for the evaluation of the diagnostic accuracy of Cat B and sICAM-1 for peri-implantitis.

Results:

Patients in the peri-implantitis group presented increased PD, SBI, CAL, PLI, and levels of IL-1β, TNF-α, IL-6, Cat B, and sICAM-1 in GCF in comparison to those in the healthy implant group (P < 0.05). Pearson test exhibited that the levels of Cat B and sICAM-1 in the GCF were positively correlated with PD, SBI, CAL, PLI, IL-1β, TNF-α, and IL-6. ROC analysis revealed that the area under the curve for Cat B and sICAM-1 levels alone and in combination were 0.798, 0.741, and 0.829, respectively, with sensitivity of 58.46%, 55.38%, and 73.85% and the specificity of 91.01%, 89.89%, and 84.27%, respectively.

Conclusion:

Our study demonstrates that Cat B and sICAM-1 are upregulated in the GCF of patients with peri-implantitis and correlate with the inflammation level and the degree of disease, and have a predictive value in the development of peri-implantitis.

Other:

Cat B and sICAM-1 have certain diagnostic abilities for peri-implantitis. However, further experiments with a larger number of subjects are necessary to elucidate whether these molecules could be served as vital biomarkers of peri-implantitis.
Secure Patient Data Monitoring and Efficient Routing Optimization using
a Hyperelliptic Curve Cryptography with Fuzzy-based Priority in WBSN
Authors: Mariappan Dinesh Babu , Saminathan R. , Baalamurugan K.M.
Published: August 2023

Aims and Background:

Wireless Body Sensor Network (WBSN) technology is one of
the major research areas in the medical and entertainment industries. A wireless sensor network
(WSN) is a dense sensor network that senses environmental conditions, processes, and outgoing
data at the sink node. A WBSN develops patient monitoring systems that provide the flexibility and
mobility needed to monitor patient health. In data communications, it is difficult to find flexible optical
routing paths, switching capabilities, and packet processing in the composition of optical networks.
Information-centric networks (ICNs) are a new network model and are different from information-
centric models. The priority of the information-centric model is the communication network.

Objectives:

In the existing literature, such methods are typically developed using computationally
expensive procedures, such as bilinear pairing, elliptic curve operations, etc., which are unsuitable
for biomedical devices with limited resources. Using the concept of hyperelliptic curve cryptography
(HECC), we propose a new solution: a smart card-based two-factor mutual authentication
scheme. In this new scheme, HECC’s finest properties, such as compact parameters and key sizes,
are utilized to enhance the real-time performance of an IoT-based TMIS system.

Methodology:

A fuzzy–based Priority Aware Data Sharing (FPADS) method is introduced to
schedule the priority data and monitor the transmission length. The child node adjusts the transmission
speed of the cluster head with the help of a fuzzy logic controller (FLC).

Results:

The proposed model estimated the traffic load of the child node and the priority of the different
amounts of data to be transmitted. The principle of scheduling data packets to be developed is
based on the precedence of the data with the lowest transmit length in the network.

Conclusion:

The proposed FPADS performance increases in terms of scheduling time utilisation,
traffic distribution, and mean delay. Simulations have been done using NS2, and the outcomes have
shown that the proposed methodology is efficient and improves the overall QoS of the system.
Buffer Management Techniques in Delay Tolerant Networks: A
Comprehensive Survey
Authors: Singh Savita , Verma Ankita
Published: August 2023

This paper aims to provide a comprehensive study of the underlying buffer management
issues and challenges in developing an efficient DTN routing protocol. Our aim is to begin with the
discussion of buffer management schemes in DTNs in full generality and then dive in-depth, covering
aspects of buffer management. Buffer strategies are used to determine which packets need to be
forwarded or dropped. This paper will focus on the variety of buffer management strategies available,
providing a comprehensive survey and analysis. We have also conducted an empirical analysis
using simulator ONE to analyze the buffering time in various primary routing protocols such as
Epidemic, Spary-and-wait (SNW), Prophet, Encounter based Routing (EBR) and Inter-Contact
Delay and Location Information based Routing (ICDLIR). For these algorithms, it is also observed
how varying the buffer size effect the delivery probability and overhead.
A Review of Software and Mobile Apps to Support the Clinical Diagnosis of Hansen Disease (Preprint)
Authors: Costa Wilbert Dener Lemos , de Oliveira Alan Maicon , Aguilar Guilherme José , dos Santos Luana Michelly Aparecida Costa , dos Santos Luiz Ricardo Albano , Donato Dantony de Castro Barros , Foresto Felipe , Frade Marco Andrey Cipriani
Published: August 2023

UNSTRUCTURED

This scoping review indicates a lack of scientific articles that specifically explore software and mobile applications designed to assist in the clinical diagnosis of leprosy, and our findings have provided insights into the available tools, their usage methods, and the benefits offered by health technologies.
Perceived Patient Workload and Its Impact on Outcomes During New Cancer Patient Visits: Analysis of a Convenience Sample (Preprint)
Authors: Elkefi Safa , Asan Onur
Published: August 2023

BACKGROUND

Studies exploring the workload in health care focus on the doctors’ perspectives. The ecology of the health care environment is critical and different for doctors and patients.

OBJECTIVE

In this study, we explore the patient workload among newly diagnosed patients with cancer during their first visit and its impact on the patient’s perceptions of the quality of care (their trust in their doctors, their satisfaction with the care visits, their perception of technology use).

METHODS

We collected data from the Hackensack Meridian Health, John Theurer Cancer Center between February 2021 and May 2022. The technology use considered during the visit is related to doctors’ use of electronic health records. A total of 135 participants were included in the study. Most participants were 50-64 years old (n=91, 67.41%). A majority (n=81, 60%) of them were White, and only (n=16, 11.85%) went to graduate schools.

RESULTS

The findings captured the significant effect of overall workload on trust in doctors and perception of health IT use within the visits. On the other hand, the overall workload did not impact patients’ satisfaction during the visit. A total of 80% (n=108) of patients experienced an overall high level of workload. Despite almost 55% (n=75) of them experiencing a high mental load, 71.1% (n=96) reported low levels of effort, 89% (n=120) experienced low time pressure, 85.2% (n=115) experienced low frustration levels, and 69.6% (n=94) experienced low physical activity. The more overall workload patients felt, the less they trusted their doctors (odds ratio [OR] 0.059, 95% CI 0.001-2.34; P=.007). Low trust was also associated with the demanding mental tasks in the visits (OR 0.055, 95% CI 0.002-2.64; P<.001), the physical load (OR 0.194, 95% CI 0.004-4.23; P<.001), the time load (OR 0.183, 95% CI 0.02-2.35; P=.046) the effort needed to cope with the environment (OR 0.163, 95% CI 0.05-1.69; P<.001), and the frustration levels (OR 0.323, 95% CI 0.04-2.55; P=.03). The patients’ perceptions of electronic health record use during the visit were negatively impacted by the overall workload experienced by the patients (OR 0.315, 95% CI 0.08-6.35; P=.01) and the high frustration level experienced (OR 0.111, 95% CI 0.015-3.75; P<.001).

CONCLUSIONS

The study’s findings established pathways for future research and have implications for cancer patients’ workload. Better technology design and use can minimize perceived workload, which might contribute to the trust relationship between doctors and patients in this critical environment. Future human factors work needs to explore the workload and driving factors in longitudinal studies and assess whether these workloads might contribute to unintended patient outcomes and medical errors.
Strengthening Mental Health and Resilience Through Schools: Protocol for a Participatory Design Project (Preprint)
Authors: Kegelaers Jolan , Baetens Imke , Soyez Veerle , Van Heel Martijn , Van Hove Lisa , Wylleman Paul
Published: August 2023

BACKGROUND

Mental health problems are a main contributor to the global burden of disease in children and young people within urban environments. In response, the potential of both school- and sport-based mental health promotion interventions has been advocated. However, there exists limited insights into how sport-based interventions can be integrated within school environment. Moreover, there is a need to consider children and young people’s specific needs, challenges, and motivations when designing novel mental health promotion interventions.

OBJECTIVE

The Strengthening Mental Health and Resilience Through Schools (SMARTS) project aims to co-design an evidence-informed school-sport-based mental health promotion program. Specific objectives include (1) co-designing a multicomponent program, integrating sport sessions with class-based sessions, and complementing with educational modules for teachers and parents; (2) exploring how the mental health program can be implemented most effectively within the Brussels school system; and (3) conducting preliminary process and outcome testing of the program.

METHODS

A participatory design framework will be adopted to develop the program. This framework involves end users throughout the entire study process, from problem identification to intervention delivery and evaluation, while at the same time ensuring program development remains directly informed by the available scientific evidence.

RESULTS

Participant recruitment will commence in September 2023. The full project will be completed by March 2027.

CONCLUSIONS

With this intervention, we aim to provide a direct contribution to the promotion of children and young people’s mental health within the Brussels school context. At a broader level, conducting and documenting this large participatory design project can, hopefully, inspire other researchers to tailor their mental health programs to specific populations.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/49670
The Impact of Food Delivery App Usage on Teenagers' Body Composition: An Empirical Study in the UAE (Preprint)
Authors: Alneyadi Shaikha , Alneyadi Fatima
Published: August 2023

BACKGROUND

Background: The global COVID-19 pandemic triggered a surge in the popularity of food delivery apps, reshaping food consumption patterns. However, the impact of these apps on individuals' health, particularly teenagers' body composition, remains an area of inquiry. While prior research suggested a potential connection, no statistically significant association was established.

OBJECTIVE

Objective: This study aimed to investigate the extent of the impact of food delivery app usage on the body composition of teenagers in the UAE, seeking to ascertain whether a statistically significant relationship exists between these variables.

METHODS

Methods: Employing a comprehensive approach, this research integrated quantitative and qualitative methodologies. A structured quantitative questionnaire was administered to a sample of 300 teenagers representing diverse regions of the UAE. Additionally, in-depth semi-structured interviews were conducted with seven female participants to provide nuanced insights.

RESULTS

Results: The study findings indicated a lack of statistically significant correlation between teenagers' body composition and their use of food delivery apps (p > 0.05). Among the participants, 48% reported using food delivery apps, while 52% did not engage with these platforms. The mean body mass index (BMI) of app users was 21.8 (95% CI: 21.3-22.3), while non-users exhibited a mean BMI of 21.6 (95% CI: 21.1-22.1). The p-value for the BMI comparison was 0.654, suggesting no significant difference. Qualitative analysis revealed a range of factors influencing app usage, including convenience, taste preference, and social norms.

CONCLUSIONS

Conclusions: Contrary to initial assumptions, this study's results highlight a lack of statistically significant association between teenagers' body composition and their use of food delivery apps. The absence of a significant link suggests that other factors, such as genetics, physical activity, and broader lifestyle choices, play a more substantial role in shaping body composition outcomes. Ultimately, while food delivery apps have transformed the food consumption landscape, their direct impact on teenage body composition appears less pronounced. This insight underscores the complex interplay of various factors that contribute to individuals' health and well-being in the digital age.

CLINICALTRIAL

Trial Registration: This randomized controlled trial has been registered with ClinicalTrials.gov under identifier NCT123456.
How to Promote Your Publication (Preprint)
Authors: Mitragotri Suhanee , Chen David , Marzouk Sammer Mohamad , Phan Paul , Abji Noah
Published: August 2023

UNSTRUCTURED

Academic journals are venues that share peer-reviewed research to the medical community, but in order for that research to reach the general public, the complex topics need to be translated into lay findings and promoted to the public. To do so, authors can promote their article in the media, including magazines, blogs, news outlets, and social media, which allows the greater public to have access to accurate medical information. Here, we recommend three key methods to promote your publication: 1) share your research with your scholarly network, 2) write a press release to send to journalists working for magazines or blogs, 3) ensure that your research is easy to access, and 4) publicize your article on social media.
The Role of City Spatial Plan (RTRW) on Regional Development in Depok City (West Java Province)
Authors: Luthfiah Fikhi , Guswandi Guswandi , Anggrahita Hayuning
Published: August 2023

Depok City has a role as one of the buffer cities in the Jakarta Metropolitan Area (JMA). Therefore, it has been projected as a residential area and inter-city connection. The latter encourages development resulting in land conversion. If land conversion occurs uncontrollably, it will pose an environmental threat and affect the economic and social conditions, such as decreasing food security capacity and augmenting exclusion and marginalization of the urban poor. Depok City Government has stipulated local regulation on the City Spatial Plan (RTRW), which controls land resource allocation and reference for spatial planning and regional development to integrate and guide all activities related to development. Therefore, this study aims to analyze the development level in Depok City and the impact of RTRW on the development level in Depok City. This study uses a composite index to determine the regional development level and a chi-square test to see the correlation between RTRW regulation and regional development level. Depok City is developing to the north, south, and southeast. RTRW has encouraged regional development in Depok City, although there exist disparities in development levels throughout the region.
Potential Tourism Attraction of Cokro Cave, Gunungkidul Regency as a Special Interest Tourism Development
Authors: Rohani Elisa Dwi , Baiquni Muhammad , Wijono Djoko , Soeprihanto John
Published: August 2023

Cave tracing activities have now become a special interest in tourist activities with kars cave as a tracing ground. One of the attractions is because of the physical shape of the cave or what is called (speleotherm). Speleotourism has a charm and experience that is different from other tourist destinations because not all regions in Indonesia have karst areas that are ideal to be developed as Speleo tourism areas, one of which is Gunungkidul Regency which has 5 caves which are geosites, one of which is Cokro Cave.  Cokro Cave was first discovered by nature lovers from the Acintyacunyata Speleological Club (ASC) community in 1993, and in 2009 it began to develop into a tourist attraction managed directly by the local community. This study was conducted to explain how the development of special interest tourism occurred in the tourist attraction of Cokro Cave by utilizing the characteristics and uniqueness of the cave, but still paying attention to the preservation of the cave, as well as the role of local communities, government, and tourism development stakeholders. The concept of special interest tourism that can be applied in the Cokro Cave Area is the management of special interest tourism by limiting the number of visitors to maintain the preservation of the context and collaboration with tourist attractions around and with the Pokdarwis (Kelompok Sadar Wisata) management of the Cave Area. Referring to the six criteria of special interest tourism based on experts, it can be seen that the principles of special interest tourism have not been fully fulfilled in the tourist attraction of Cokro Cave, including no periodic studies on the condition of the cave, as well as monitoring the condition of the cave.
Migration Practices in Europe: Economic and Cultural Factors
Authors: Syzdykova Zhibek , Koblandin Kalybek , Medvedev Nikolay
Published: August 2023

This research aimed to identify the economic and cultural factors of migration in Europe within the context of contemporary economic and social realities. To achieve the research objective, a comprehensive multi-stage research project was developed and implemented, incorporating the advantages of statistical analysis, monitoring, rating and summary statistics. The research relied on harmonized and validated statistical data from 48 European countries, divided into four sub-regions, serving as the informational foundation for the study. Using summary statistics on migration factors in the context of economic and cultural factors made it possible to demonstrate the importance of considering cultural human rights in the country’s migration policy. An interpretation of migration practices in Europe by this means enables us to highlight the cultural context as a determining indicator, based on an analysis of objective indicators in the development of migration processes.  Furthermore, the study shows that the high quality of life and cultural attractiveness of the national policy stimulates the migration intentions of a person to seek out countries with more developed economies.The findings of this study hold relevance for policymakers and specialists in public administration, particularly those involved in the regulation and control of migration. Additionally, academic researchers can benefit from the empirical regularities established in this research and the identified prospective avenues for future investigations.