bluuebunny/crossref_metadata_2025 huggingface dataset:
Lumbo-Pelvic Rhythm Monitoring Using Wearable Technology with Sensory Biofeedback: A Systematic Review
Authors: García-Jaén Miguel , Sebastia-Amat Sergio , Sanchis-Soler Gema , Cortell-Tormo Juan Manuel
Published: March 2024

As an essential lower-back movement pattern, lumbo-pelvic rhythm (LPR) during forward trunk flexion and backward return has been investigated on a large scale. It has been suggested that abnormalities in lumbo-pelvic coordination are related to the risk of developing low back disorders. However, considerable differences in the approaches used to monitor LPR make it challenging to integrate findings from those investigations for future research. Therefore, the aim of this systematic review was to summarize the use of wearable technology for kinematic measurement with sensory biofeedback for LPR monitoring by assessing these technologies’ specific capabilities and biofeedback capacities and exploring their practical viability based on sensor outcomes. The review was developed following the PRISMA guidelines, and the risk of bias was analyzed using the PREDro and STROBE scales. PubMed, Web of Science, Scopus, and IEEEXPLORE databases were searched for relevant studies, initially returning a total of 528 articles. Finally, we included eight articles featuring wearable devices with audio or vibration biofeedback. Differences in protocols and limitations were also observed. This novel study presents a review of wearable tracking devices for LPR motion-mediated biofeedback for the purpose of correcting lower back posture. More research is needed to determine the long-term effectiveness of these devices, as well as their most appropriate corresponding methodologies.
Cross-Cultural Adaptation and Validation of the Portuguese Version of the Multidimensional Scale of Dating Violence 2.0 in Young University Students
Authors: Tarriño-Concejero Lorena , Cerejo Dalila , Arnedillo-Sánchez Socorro , Praena-Fernández Juan Manuel , García-Carpintero Muñoz María Ángeles
Published: March 2024

Background: Dating violence has become a problem of social relevance with short- and long-term health consequences. Nurses are in a privileged position to detect and address this problem in health facilities and as school nurses in schools, providing health education and detecting this violence correctly. Aim: The aim of this study was to evaluate the cross-cultural validation of the Portuguese version of the Multidimensional Scale of Dating Violence-Short (MSDV 2.0). Methods: A validation investigation was carried out in two phases: (1) cross-cultural adaptation of the items and content validation of the Portuguese version of MSDV 2.0 and (2) psychometric validation. Results: Phase (1): The items of the original version include a cross-cultural translation from Spanish to Portuguese and analysed by a group of experts in gender violence and by the authors of the original scale, then a back translation was made and again reviewed by the experts. Young university students also participated for face validity, and a pilot test was carried out. Phase (2): Confirmatory factor analysis was performed using the robust maximum-likelihood estimation method, which confirmed the five-dimensional structure, obtaining good fit rates (chi-square significance (χ2) = 187.860 (p < 0.0001); root mean square error of approximation (RMSEA) = 0.049; comparative fit index (CFI) = 0.937; Tucker–Lewis index (TLI) = 0.923). Reliability analysis indicated adequate internal consistency (Cronbach’s alpha (α) = 0.88 to 0.70). Finally, scores of the Portuguese versions MSDV 2.0 were correlated, as expected, positively with the Depression, Anxiety, and Stress Scale (DASS-21) (r = 0.36 to 0.16) and negatively with the Medical Outcomes Study Questionnaire Short Form 36, Health Survey (SF-36) (r = −0.30 to −0.14). Conclusions: To date, it is the only instrument that measures dating violence in a multidimensional way validated in the Portuguese university context.
Perceptions of the Conditions and Barriers in Implementing the Patient Blood Management Standard by Anesthesiologists and Surgeons
Authors: Kazamer Andrea , Ilinca Radu , Stanescu-Spinu Iulia-Ioana , Lutescu Dan Adrian , Greabu Maria , Miricescu Daniela , Coricovac Anca Magdalena , Ionescu Daniela
Published: March 2024

Patient Blood Management (PBM) as a multidisciplinary practice and a standard of care for the anemic surgical patient is playing an increasingly important role in reducing transfusions and optimizing both clinical outcomes and costs. The success of PBM implementation depends on staff awareness and involvement in this approach. The main objective of our study was to explore physicians’ perceptions of the conditions for implementing PBM in hospitals and the main obstacles they face in detecting and treating anemic patients undergoing elective surgery. This cross-sectional descriptive study includes 113 Romanian health units, representing 23% of health units with surgical wards nationwide. A 12-item questionnaire was distributed to the participants in electronic format. A total of 413 questionnaires representing the perceptions of 347 surgeons and 66 anesthesia and intensive-care specialists were analyzed. Although a lack of human resources was indicated by 23.70% of respondents as the main reason for not adhering the guidelines, the receptiveness of medical staff to implementing the PBM standard was almost 90%. In order to increase adherence to the standard, additional involvement of anesthesia and intensive-care physicians would be necessary from the perception of 35.70% of the responders: 23.60% of surgeons and 18.40% of hematologists.
Changes in Baropodometric Evaluation and Discomfort during the Workday in Assembly-Line Workers
Authors: Rabal-Pelay Juan , Cimarras-Otal Cristina , Lacárcel-Tejero Belén , Alcázar-Crevillén Andrés , Villalba-Ruete José Antonio , Berzosa César , Bataller-Cervero Ana Vanessa
Published: March 2024

Prolonged standing at work is associated with health risks. The appearance of lower-limb and lower-back discomfort is one of the most prevalent factors in prolonged standing workers. The aim of this research was to evaluate the effect of an eight-hour workday on foot pressure and musculoskeletal discomfort in standing workers. Thirty-six assembly-line workers (six women) were recruited to participate in a cross-sectional study to assess foot pressure and surface, foot, knee, and lower-back discomfort before and after a real workday. Baropodometry outcomes (surface and pressure) were evaluated by the pressure platform SensorMedica and musculoskeletal discomfort was evaluated by Cornell’s Musculoskeletal Discomfort Questionaire. Total foot surface (p = 0.01) and foot discomfort (p = 0.03) increased significantly at the end of the workday. Prolonged standing during 8 h workday increased the foot discomfort and total foot surface in assembly-line workers. No foot pressure variable (forefoot, rearfoot, or total) was significantly modified after the workday in assembly-line workers.
Health Literacy and Self-Care in Patients with Chronic Illness: A Systematic Review and Meta-Analysis Protocol
Authors: Magi Camilla Elena , Bambi Stefano , Rasero Laura , Longobucco Yari , El Aoufy Khadija , Amato Carla , Vellone Ercole , Bonaccorsi Guglielmo , Lorini Chiara , Iovino Paolo
Published: March 2024

Self-care plays a critical role in symptom recognition, management, and risk factor modification for patients with chronic illnesses. Despite its significance, self-care levels in this population are generally poor. Health literacy (HL) is pivotal for promoting effective self-care, yet the association across specific chronic illnesses remains fragmented and conflicting. Therefore, a systematic review and meta-analysis will be conducted. Inclusion criteria encompass quantitative studies involving adult patients with at least one chronic illness reporting on the association between a measure of HL and one or more elements of self-care behaviors as outcomes. Databases to be searched include PubMed, CINAHL, APA PsycINFO, Embase, Web of Science, and Cochrane Central Register of Controlled Trials. The studies will undergo risk of bias and certainty of evidence assessment using ROBINS-E and GRADE. Extracted data will include authors, publication date, aim(s), study location, design, sample characteristics, chronic illness type, study length, HL, and self-care measures. Understanding the link between HL and self-care can aid healthcare providers in implementing strategies to enhance health-promoting behaviors, contributing valuable insights to the scientific community and fostering nuanced discussions. This protocol ensures methodological transparency, stimulates discourse, and paves the way for informed interventions to improve overall health outcomes.
An Importance-Performance Analysis of Korean Middle School Students’ Health Management Awareness during the Post-COVID-19 Era Depending on Sex
Authors: Kim Chul-Min , Huang Yi-Hang , Zhou Tong , Kim Min-Jun , Youn Hyun-Su
Published: March 2024

This study aimed to conduct importance-performance analyses (IPAs) based on Korean middle school students’ health management awareness during the post-coronavirus disease 2019 (COVID-19) era. Data were collected from 867 Korean middle school students (13–15 years old) via online and offline surveys between May and June 2023. Frequency analysis, reliability analysis, IPA based on the entire student group, and IPA depending on sex were carried out with the collected data, which revealed the following. First, regardless of sex, the IPA results indicated that four factors of mental health were located in the third quadrant, with one factor of the same variable in the fourth quadrant. The three factors of disease management were located in the third quadrant. Regarding physical activity, two factors were located in the first quadrant, one in the second quadrant, and one in the third quadrant. Regarding sleep management, two factors were located in the second quadrant, one in the third quadrant, and one in the first quadrant. Regarding eating management, two factors were located in the third quadrant and one in the fourth quadrant. Regarding the social distancing variable, all four factors were located in the third quadrant. Regarding hygiene management, two factors were located in the first quadrant, one in the third quadrant, and one in the fourth quadrant. Furthermore, the IPA results indicated sex differences in regular sports and vigorous movement activities associated with physical activity. Additionally, a sex difference was observed in regular diet associated with eating management. This study proposed possible measures for encouraging middle school students to recognize the importance of health and increase their health-related performance during the COVID-19 endemic phase.
A Conceptual Study on Characterizing the Complexity of Nutritional Interventions for Malnourished Older Adults in Hospital Settings: An Umbrella Review Approach
Authors: Wong Alvin , Huang Yingxiao , Banks Merrilyn D. , Sowa P. Marcin , Bauer Judy D.
Published: March 2024

Introduction: Malnutrition is a widespread and intricate issue among hospitalized adults, necessitating a wide variety of nutritional strategies to address its root causes and repercussions. The primary objective of this study is to systematically categorize nutritional interventions into simple or complex, based on their resource allocation, strategies employed, and predictors of intervention complexity in the context of adult malnutrition in hospital settings. Methods: A conceptual evaluation of 100 nutritional intervention studies for adult malnutrition was conducted based on data from a recent umbrella review (patient population of mean age > 60 years). The complexity of interventions was categorized using the Medical Research Council 2021 Framework for Complex Interventions. A logistic regression analysis was employed to recognize variables predicting the complexity of interventions. Results: Interventions were divided into three principal categories: education and training (ET), exogenous nutrient provision (EN), and environment and services (ES). Most interventions (66%) addressed two or more of these areas. A majority of interventions were delivered in a hospital (n = 75) or a hospital-to-community setting (n = 25), with 64 studies being classified as complex interventions. The logistic regression analysis revealed three variables associated with intervention complexity: the number of strategies utilized, the targeted areas, and the involvement of healthcare professionals. Complex interventions were more likely to be tailored to individual needs and engage multiple healthcare providers. Conclusions: The study underlines the importance of considering intervention complexity in addressing adult malnutrition. Findings advocate for a comprehensive approach to characterizing and evaluating nutritional interventions in future research. Subsequent investigations should explore optimal balances between intervention complexity and resource allocation, and assess the effectiveness of complex interventions across various settings, while considering novel approaches like telehealth.
The Combination of High-Light Efficiency Pruning and Mulching Improves Fruit Quality and Uneven Maturation at Harvest in Camellia oleifera
Authors: Si Yuanyuan , Lu Yifan , Bai Qian , Sun Yongjiang , Su Shuchai
Published: March 2024

Camellia oleifera Abel is rich in oil, which is beneficial to human health. Seasonal drought and uneven canopy microclimate distributions result in low yields and picking efficiencies. To reveal the features of fruit development in the canopy and evaluate the impact of pruning on the canopy microclimate and fruit parameters, a field experiment was carried out in Zhuzhou, Hunan. The C. oleifera tree canopy was divided into four positions: inside the upper canopy (UI); inside the lower canopy (LI); outside the upper canopy (UO); and outside the lower canopy (LO). A combination of high-light efficiency tree pruning and mulching with camellia shells and weedproof film (CPM) was tested and compared with mulching (M). Compared with temperature and humidity, canopy light intensity is a key climate factor that affects the development of Camellia oleifera fruits. CPM improved the canopy light distribution and increased the light intensity inside the canopy of C. oleifera. There was no significant difference in the fruit cracking rate among the four canopy positions in the CPM treatment, which indicated that the fruit maturation period tended to be consistent across the canopy positions. Treatment with CPM resulted in 24.14% and 4.11% greater yield and oil content ratios, respectively, than the treatment with M. The fresh weight of the fruits from LO was the lowest, and the fatty acid accumulation was the lowest due to the poor light availability. CMP increased fruit quality, particularly in LI, which was 41.92%, 36.36%, 13.21%, and 12.79% greater in terms of fresh weight, yield, fresh seed rate, and oil content, respectively, than M. Unfortunately, there was no discernible difference in fatty acid components between CPM and M. Our research suggested that pruning combined with the mulching of organic material is an effective way to alleviate seasonal drought and uneven fruit maturation in C. oleifera trees, further increasing yield and fruit quality.
Potassium and Magnesium in American Ginseng Roots as Key Factors in Monitoring Soil Quality, Yield, and Quality: Screening, Prediction, and Validation
Authors: Qian Jiaqi , Sun Hai , Shao Cai , Liang Hao , Cao Weiyu , Lv Bochen , Zhang Yayu
Published: March 2024

Understanding the key roles of nutrient elements in soil–plant systems are essential for herbal medicine production and sustainable development. However, the ecological relationships between soil quality and nutrient elements, yield, saponins, or other active compounds in American ginseng remain unclear. In this study, 20 soil indicators, 10 root nutrient indicators, 9 quality indicators, and yields were investigated. The minimum dataset was constructed by principal component analysis, key factors were screened by correlation analysis and PLS-PM analysis, and the prediction model was constructed using linear fitting and tested by a validation test. The minimum dataset, constructed based on principal component analysis, comprised five indicators: SOM, TP, AK, AMg, and ACa. Correlation analysis, PLS-PM analysis, and linear fitting showed that K and Mg were the key factors relating soil quality to the yield and quality of American ginseng and that when AMg was 0.21 g/kg and AK was 0.30 g/kg, soil organic matter was 27%, total phosphorus was 1.19 g/kg in soil, K content in roots was 15.63 g/kg, Mg content was 1.91 g/kg, and the K/Mg of 8.85 could balance American ginseng yield and quality. In predicting and validating the model, predicting the DW, total ginsenoside, Rb1, Rb2, Rc, and Rd of American ginseng using K/Mg were reliable. This study provides a scientific basis for nutrient regulation, selecting planting sites, assessing soil quality, and predicting and evaluating American ginseng quality.
Detection of Hardening in Mangosteens Using near-Infrared Hyperspectral Imaging
Authors: Workhwa Saranya , Khanthong Thitirat , Manmak Napatsorn , Thompson Anthony Keith , Teerachaichayut Sontisuk
Published: March 2024

Mangosteens can develop a postharvest physiological disorder, called “hardening”, which affects their marketability and is not detectable using visual inspection. The hardening disorder of mangosteens was determined by firmness value using the texture analyzer. Near-infrared hyperspectral imaging (NIR-HSI) in the region of 935–1720 nm was tested as a possible rapid and non-destructive method to detect this disorder. The spectra from a region of interest of mangosteens were acquired and used for analysis. Calibration models for firmness of a similarly sized group and a mixed-size group were established using partial least squares regression (PLSR) and support vector machine regression (SVMR). Chemometric algorithms were investigated in order to determine the optimal conditions for establishing the models for firmness. The optimum model was obtained when the fruit were graded into similarly sized groups. Using partial least squares regression (PLSR), the correlation coefficient of prediction (Rp) was 0.87 and the root mean square error of prediction (RMSEP) was 6.25 N. The predictive images for firmness of the fruit were created by interpreting predicted firmness visualized as colors in every pixel. From the data, it was concluded that NIR-HSI can potentially be used to visualize hardening of individual mangosteens based on their predictive images.
Effects of Gibberellic Acid on Soluble Sugar Content, Organic Acid Composition, Endogenous Hormone Levels, and Carbon Sink Strength in Shine Muscat Grapes during Berry Development Stage
Authors: Li Xiujie , Cai Zhonghui , Liu Xueli , Wu Yusen , Han Zhen , Yang Guowei , Li Shaoxuan , Xie Zhaosen , Liu Li , Li Bo
Published: March 2024

The phytohormone gibberellic acid (GA3) is widely used in the table grape industry. However, there is a paucity of information concerning the effects of GA3 on fruit quality and sink strength. This study investigated the effects of exogenous GA3 treatments (elongating cluster + seedless + expanding, T1; seedless + expanding, T2; expanding, T3; and water, CK) on the content of sugars, organic acids, and endogenous hormones and sink strength. Results showed that T2 treatment displayed the highest fructose and glucose levels at 100 days after treatment (DAT), whereas its effect on tartaric acid, malic acid, and citric acid concentrations at 80 and 100 DAT was relatively weak. Under GA3 treatments, GA3, IAA, and CTK contents increased, whereas ABA content decreased at 1, 2, 4, 8, and 48 h. Analysis of sugar phloem unloading revealed that T2 treatment exhibited the highest values during softening and ripening stages. Our findings indicate that appropriate GA3 application can positively influence sink strength by regulating sink size and activity, including berry size enlargement, sugar phloem unloading, and sugar accumulation in grape sink cells.
Prediction of Weekly Price Trend of Garlic Based on Classification Algorithm and Combined Features
Authors: Sun Feihu , Meng Xianyong , Zhang Hongqi , Wang Yue , Liu Pingzeng
Published: March 2024

To promote the sustainable development of the garlic industry and provide a reference for the prediction of agricultural product price trends, this study used the garlic price in Jinxiang, China as the research object. First, the feature combination De was obtained by extracting the sequence obtained using VMD decomposition. Then, the De_Vo combined feature was constructed by combining the volatility feature Vo. Classification algorithms, such as logistic regression, SVM, and XGBoost, were used to classify and predict the garlic price trend. The results showed that the prediction results based on the combined features were better than those based on the single De or Vo features. In the binary classification prediction, the accuracy values for LR, SVM, and XGBoost were 62.6%, 71.4%, and 72.9%, respectively. Among them, the XGBoost algorithm performed better than the LR and SVM algorithms in the three-class, four-class, and five-class predictions.
Human-Following Strategy for Orchard Mobile Robot Based on the KCF-YOLO Algorithm
Authors: Huang Zhihao , Ou Chuhong , Guo Zhipeng , Ye Lei , Li Jin
Published: March 2024

Autonomous mobile robots play a vital role in the mechanized production of orchards, where human-following is a crucial collaborative function. In unstructured orchard environments, obstacles often obscure the path, and personnel may overlap, leading to significant disruptions to human-following. This paper introduces the KCF-YOLO fusion visual tracking method to ensure stable tracking in interference environments. The YOLO algorithm provides the main framework, and the KCF algorithm intervenes in assistant tracking. A three-dimensional binocular-vision reconstruction method was used to acquire personnel positions, achieving stabilized visual tracking in disturbed environments. The robot was guided by fitting the personnel’s trajectory using an unscented Kalman filter algorithm. The experimental results show that, with 30 trials in multi-person scenarios, the average tracking success rate is 96.66%, with an average frame rate of 8 FPS. Additionally, the mobile robot is capable of maintaining a stable following speed with the target individuals. Across three human-following experiments, the horizontal offset Error Y does not exceed 1.03 m. The proposed KCF-YOLO tracking method significantly bolsters the stability and robustness of the mobile robot for human-following in intricate orchard scenarios, offering an effective solution for tracking tasks.
Effect of Different LED Light Wavelengths on Production and Quality of Pleurotus ostreatus Grown on Different Commercial Substrates
Authors: De Bonis Marina , Locatelli Silvia , Sambo Paolo , Zanin Giampaolo , Pecchia John A. , Nicoletto Carlo
Published: March 2024

Artificial lighting, primarily employed in crop production, can also be applied to the cultivation of edible mushrooms to enhance productivity and quality. While UV radiation has predominantly been investigated in post-harvest treatments for edible mushrooms, the utilization of different light wavelengths during the cultivation phase remains largely unexplored for many mushroom species. This study aimed to assess the impact of three different light wavelengths 450 nm (B), 610 nm (R), and a combination of these two wavelengths (R + B) on the productive characteristics and quality of Pleurotus ostreatus, cultivated using three straw-based commercial substrates. It was observed that, except for yield, artificial light influenced mushroom growth. Specifically, the application of R light appeared to promote mycelium growth, whereas B light contributed to increase the diameter of fruiting bodies. Additionally, the concentration of vitamin D2 was higher under both B and R+B light treatments. Interestingly, the light treatments did not affect yield but impacted diameter and various chemical attributes such as EC, total soluble solids, and titratable acidity. In conclusion, exposure to different lighting affected Pleurotus ostreatus physiology and nutritional content.
‘Juxiangyuan’ Seedless Orange: A New Mutant with Male and Female Sterility
Authors: Zhang Feng , Wang Qinggang , Luo Jianming , Gentile Alessandra , Long Guiyou , Deng Ziniu , Li Dazhi , Li Na
Published: March 2024

Seedless is a highly valued commercial characteristic in the citrus industry, both for fresh consumption and for processed markets. In this study, the ‘Succari Sweet Orange’ (WT) and its seedless mutant ‘Juxiangyuan’ (MT), which originated from a bud mutation, were selected to study the formation of a citrus seedless phenotype. Microscopic analysis of MT’s floral organs, including anther and ovary cross-sections, provides insights into its seedless phenotype compared to the original seeded cultivar. Additionally, pollen features, viability, and in vitro germination were examined to determine the cause of seedlessness. MT exhibited significant developmental deformities in both male and female gametes, with pollen grain analysis indicating a high rate of deformity (41.48%), low viability (9.59%), and minimal in vitro germination (9.56%). Hybridization experiments were conducted to assess male and female sterility and pollen incompatibility. Both WT and MT exhibited parthenocarpic development. Notably, MT fruit produced with an average of 3.51 seeds pollinated to WT, despite severe pollen abortion of MT. MT, however, produced seedless fruit through self-breeding or cross-breeding with other varieties, demonstrating stable female sterility. Despite reduced pollen quantity and viability in the seedless mutant ‘Juxiangyuan’, its seedlessness primarily stems from female sterility. This study contributed to a deeper understanding of seedless formation in ‘Juxiangyuan’ and provided valuable information relevant to its commercial cultivation.
Fuzzy Finite Elements Solution Describing Recession Flow in Unconfined Aquifers
Authors: Tzimopoulos Christos , Papadopoulos Kyriakos , Samarinas Nikiforos , Papadopoulos Basil , Evangelides Christos
Published: March 2024

In this work, a novel fuzzy FEM (Finite Elements Method) numerical solution describing the recession flow in unconfined aquifers is proposed. In general, recession flow and drainage problems can be described by the nonlinear Boussinesq equation, while the introduced hydraulic parameters (Conductivity K and Porosity S) present significant uncertainties for various reasons (e.g., spatial distribution, human errors, etc.). Considering the general lack of in situ measurements for these parameters as well as the certain spatial variability that they present in field scales, a fuzzy approach was adopted to include the problem uncertainties and cover the disadvantage of ground truth missing data. The overall problem is encountered with a new approximate fuzzy FEM numerical solution, leading to a system of crisp boundary value problems. To prove the validity and efficiency of the new fuzzy FEM, a comparative analysis between the proposed approach and other well-known and tested approximations was carried out. According to the results, the proposed FEM numerical solution agrees with Karadinumerical method for the crisp case and is in close agreement with the original analytical solution proposed by Boussinesq in 1904 with the absolute reduced error to be 4.6‰. Additionally, the possibility theory is applied, enabling the engineers and designers of irrigation, drainage, and water resources projects to gain knowledge of hydraulic properties (e.g., water level, outflow volume) and make the right decisions for rational and productive engineering studies.
Measuring Community Response to Noise—Factors Affecting the Results of Annoyance Surveys
Authors: Gjestland Truls
Published: March 2024

Social surveys are conducted to determine how annoyed people are in a certain noise situation. The results are typically presented as exposure–response curves showing the percentage of the area population that are highly annoyed as a function of the noise exposure level. It is a well-known fact that the survey results are not only dependent on the accumulated noise exposure, DNL, DENL, or similar, but also on various other factors such as maximum levels, exposure patterns, noise spectra, etc. A re-analysis of previously reported surveys shows that the results are also, to a large extent, dependent on survey-specific factors like the wording of the annoyance questions, how the questionnaires are presented, response scales, methods of scoring highly annoyed, etc. This paper discusses and quantifies the influence of such factors and suggests ways of comparing results from surveys that have been conducted according to different protocols and different analysis methods.
Community Transport’s Dual Role as a Transport and a Social Scheme: Implications for Policy
Authors: Ravensbergen Léa , Schwanen Tim
Published: March 2024

Community transport comprises diverse local, not-for-profit, and primarily volunteer-run transport schemes that operate across the United Kingdom. These schemes support the travel needs of thousands of people, most of whom are older, live in rural areas, and have few other transport options. Further, this transport sector is unique in that most schemes are designed, created, and run by older people themselves. And yet, community transport has thus far received relatively little attention in both policy and research. Using semi-structured interviews with community transport providers in Oxfordshire, this paper proposes community transport as a practice guided by phronesis and argues that it has been made to hold a dual role as both a transport and a social scheme. The transport it provides is unique in being made low-cost, flexible, and functionally accessible. It has also been made into a social scheme as it helps those with few other options, provides benefits that extend beyond the transport realm, and fosters community. Though this dual role means that community transport has many cross-sectoral benefits, this type of service provision is found to be overlooked in both national and local policy, which has enabled the constitutive role of phronesis in community transport. Given this, there are challenges ahead for the sector in both ensuring its sustainability and maintaining its ability to respond closely to users’ needs.
A Needs Assessment Approach for Adolescent and Young Adult Sexual and Gender Diverse Cancer Survivors
Authors: Ghazal Lauren V. , Johnston Hailey , Dodd Elisabeth , Ramachandra Yasmine , Giallourakis Nicholas , Fulginiti Kayla , Kamen Charles
Published: March 2024

Sexual and gender diverse (SGD) adolescent and young adult (AYA) cancer survivors are an increasing and vulnerable group with unique needs that often remain unmet in the healthcare system. This paper describes the conceptualization and development of a community-based organization dedicated to serving SGD AYAs, in addition to reporting on the results of a community-led needs assessment. A total of 56 SGD AYA community members completed the online survey. Most participants were between the ages of 26 to 33, identified as white, cisgender, bisexual women, and had hematologic malignancies. Identified unmet needs of SGD AYAs included the following: sexual health and family planning; gender affirmation; financial stability; and emotional support. Areas within the community organization were identified as gaps, areas of expansion, and assets. Results highlight the role of community and academic partnerships in improving cancer care delivery for SGD AYA cancer survivors.
Relational Coordination at the Primary–Secondary Care Interface: Insights from a Cross-Sectional Survey in the South Tyrolean Healthcare System
Authors: Wiedermann Christian J. , Barbieri Verena , Engl Adolf , Piccoliori Giuliano
Published: March 2024

Understanding the dynamics of teamwork and communication among healthcare professionals is crucial in the face of evolving healthcare challenges. This study assessed relational coordination among healthcare professionals in the South Tyrolean healthcare system in Italy, focusing on communication and teamwork dynamics in a cross-sectional survey. Using the validated Relational Coordination Survey (RCS) instrument and 525 completed online responses, the questionnaire aimed to understand the implications of different levels of relational coordination ratings by general practitioners, hospital physicians, nurses, and administrative personnel (response rate 26%). The demographics of the participants revealed a predominance of female professionals (64%), with an average age of 50 and 18 years of service. The resulting RCS scores varied significantly across professional groups, with nurses reporting the highest within-group scores, indicating moderate coordination, and administrators reporting the lowest scores, reflecting areas of weak coordination. Between-group relational coordination was generally perceived as weak across professional groups, with the least weakness observed between general practitioners and nurses. German or Italian language and health district affiliation emerged as significant factors influencing relational coordination ratings, highlighting the need for differentiated understanding and strategies in multilingual and diverse regional settings. Assessments of interdisciplinary feedback and referral practices highlight the variation in teamwork and communication weaknesses and underscore the need for targeted interventions to improve relational coordination. This study provides insights into the complexity of relational dynamics in health care settings. This suggests that improving relational coordination through tailored strategies could significantly improve team effectiveness, quality of patient care, and overall system efficiency.
Heavy Metals Content and Health Risk Assessment in Airborne Particulate from the Calabria Region, Southern Italy
Authors: Caridi Francesco , Paladini Giuseppe , Messina Maurizio , Majolino Domenico , Venuti Valentina
Published: March 2024

This study is focused on the determination of the heavy metals content in airborne particulate matter (PM) with a diameter lower than 10 µm (PM10) deposited on quartz microfiber filters and collected in four representative selected sites of the Calabria region, southern Italy. In particular, data on the content of Cd, Ni, and Pb in PM10 (i.e., those metals whose limit values, in terms of concentration, are reported in the Italian Legislation) were obtained through inductively coupled plasma mass spectrometry (ICP-MS) measurements after acid extraction with microwaves and filtration. Results showed that the average concentration of investigated metals decreases as Ni > Pb > Cd for all analyzed samples, and concentration values are lower than the limit values reported in the Italian legislation in all cases. Moreover, in order to assess the health risk related to their presence in the environment, the potential non-carcinogenic hazard for the investigated heavy metals was evaluated by calculating the hazard index (HI) for children and adults. Results indicated that the calculated HI values were lower than the safety limit in all cases, thus indicating a negligible non-carcinogenic health risk. In addition, the potential carcinogenic hazard for the investigated metals was estimated through the total cancer risk index (Risktotal). Obtained results were also lower than the limit value for children and adults in this case, and, therefore, the carcinogenic health risk caused by heavy metals in the analyzed PM10 samples could be considered to be unremarkable.
Factors Associated with Insured Children’s Use of Physician Visits, Dentist Visits, Hospital Care, and Prescribed Medications in the United States: An Application of Behavioral Model of Health-Services Use
Authors: Cheng Tyrone C. , Lo Celia C.
Published: March 2024

This study is the first to examine factors in the utilization of physician services, dentist services, hospital care, and prescribed medications focusing exclusively on insured children in the United States. Data describing 48,660 insured children were extracted from the 2021 National Survey of Children’s Health. Children in the present sample were covered by private health insurance, public health insurance, or other health insurance. Logistic regression results showed self-reported health to be negatively associated with physician visits, hospital-care use, and prescription use, but teeth condition to be positively associated with dentist visits. Physician visits were associated negatively with age, Hispanic ethnicity, Asian ethnicity, family income at or below 200% of the federal poverty level, and other health insurance, but positively with parental education and metropolitan residency. Dentist visits were associated positively with girls, age, and parental education, but negatively with Asian ethnicity and public health insurance. Use of hospital care was associated negatively with age and Asian ethnicity, but positively with parental education and public health insurance. Use of prescriptions was associated positively with age, Black ethnicity, parental education, and public health insurance, but negatively with Hispanic ethnicity, Asian ethnicity, and family income at or below 200% of the federal poverty level. Implications included the expansion of public health insurance, promotion of awareness of medicine discount programs, and understanding of racial/ethnic minorities’ cultural beliefs in health and treatment.
Transcriptomic Changes in Cisplatin-Resistant MCF-7 Cells
Authors: Ruiz-Silvestre Araceli , Garcia-Venzor Alfredo , Ceballos-Cancino Gisela , Sánchez-López José M. , Vazquez-Santillan Karla , Mendoza-Almanza Gretel , Lizarraga Floria , Melendez-Zajgla Jorge , Maldonado Vilma
Published: March 2024

Breast cancer is a leading cause of cancer-related deaths among women. Cisplatin is used for treatment, but the development of resistance in cancer cells is a significant concern. This study aimed to investigate changes in the transcriptomes of cisplatin-resistant MCF7 cells. We conducted RNA sequencing of cisplatin-resistant MCF7 cells, followed by differential expression analysis and bioinformatic investigations to identify changes in gene expression and modified signal transduction pathways. We examined the size and quantity of extracellular vesicles. A total of 724 genes exhibited differential expression, predominantly consisting of protein-coding RNAs. Notably, two long non-coding RNAs (lncRNAs), NEAT1 and MALAT, were found to be dysregulated. Bioinformatic analysis unveiled dysregulation in processes related to DNA synthesis and repair, cell cycle regulation, immune response, and cellular communication. Additionally, modifications were observed in events associated with extracellular vesicles. Conditioned media from resistant cells conferred resistance to wild-type cells in vitro. Furthermore, there was an increase in the number of vesicles in cisplatin-resistant cells. Cisplatin-resistant MCF7 cells displayed differential RNA expression, including the dysregulation of NEAT1 and MALAT long non-coding RNAs. Key processes related to DNA and extracellular vesicles were found to be altered. The increased number of extracellular vesicles in resistant cells may contribute to acquired resistance in wild-type cells.
Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide, and Glucagon Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Medication in New Liver Disease Nomenclature
Authors: Chrysavgis Lampros G. , Kazanas Spyridon , Bafa Konstantina , Rozani Sophia , Koloutsou Maria-Evangelia , Cholongitas Evangelos
Published: March 2024

Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins that regulate postprandial glucose regulation, stimulating insulin secretion from pancreatic β-cells in response to food ingestion. Modified GLP-1 receptor agonists (GLP-1RAs) are being administered for the treatment of obesity and type 2 diabetes mellitus (T2DM). Strongly related to those disorders, metabolic dysfunction-associated steatotic liver disease (MASLD), especially its aggressive form, defined as metabolic dysfunction-associated steatohepatitis (MASH), is a major healthcare burden associated with high morbidity and extrahepatic complications. GLP-1RAs have been explored in MASH patients with evident improvement in liver dysfunction enzymes, glycemic control, and weight loss. Importantly, the combination of GLP-1RAs with GIP and/or glucagon RAs may be even more effective via synergistic mechanisms in amelioration of metabolic, biochemical, and histological parameters of MASLD but also has a beneficial impact on MASLD-related complications. In this current review, we aim to provide an overview of incretins’ physiology, action, and signaling. Furthermore, we provide insight into the key pathophysiological mechanisms through which they impact MASLD aspects, as well as we analyze clinical data from human interventional studies. Finally, we discuss the current challenges and future perspectives pertinent to this growing area of research and clinical medicine.
The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies
Authors: Chatzikalil Elena , Stergiou Ioanna E. , Papadakos Stavros P. , Konstantinidis Ippokratis , Theocharis Stamatios
Published: March 2024

Pediatric neoplasms represent a complex group of malignancies that pose unique challenges in terms of diagnosis, treatment, and understanding of the underlying molecular pathogenetic mechanisms. Erythropoietin-producing hepatocellular receptors (EPHs), the largest family of receptor tyrosine kinases and their membrane-tethered ligands, ephrins, orchestrate short-distance cell–cell signaling and are intricately involved in cell-pattern morphogenesis and various developmental processes. Unraveling the role of the EPH/ephrin signaling pathway in the pathophysiology of pediatric neoplasms and its clinical implications can contribute to deciphering the intricate landscape of these malignancies. The bidirectional nature of the EPH/ephrin axis is underscored by emerging evidence revealing its capacity to drive tumorigenesis, fostering cell–cell communication within the tumor microenvironment. In the context of carcinogenesis, the EPH/ephrin signaling pathway prompts a reevaluation of treatment strategies, particularly in pediatric oncology, where the modest progress in survival rates and enduring treatment toxicity necessitate novel approaches. Molecularly targeted agents have emerged as promising alternatives, prompting a shift in focus. Through a nuanced understanding of the pathway’s intricacies, we aim to lay the groundwork for personalized diagnostic and therapeutic strategies, ultimately contributing to improved outcomes for young patients grappling with neoplastic challenges.
Insect Antimicrobial Peptides as Guardians of Immunity and Beyond: A Review
Authors: Zhou Lizhen , Meng Guanliang , Zhu Ling , Ma Li , Chen Kangkang
Published: March 2024

Antimicrobial peptides (AMPs), as immune effectors synthesized by a variety of organisms, not only constitute a robust defense mechanism against a broad spectrum of pathogens in the host but also show promising applications as effective antimicrobial agents. Notably, insects are significant reservoirs of natural AMPs. However, the complex array of variations in types, quantities, antimicrobial activities, and production pathways of AMPs, as well as evolution of AMPs across insect species, presents a significant challenge for immunity system understanding and AMP applications. This review covers insect AMP discoveries, classification, common properties, and mechanisms of action. Additionally, the types, quantities, and activities of immune-related AMPs in each model insect are also summarized. We conducted the first comprehensive investigation into the diversity, distribution, and evolution of 20 types of AMPs in model insects, employing phylogenetic analysis to describe their evolutionary relationships and shed light on conserved and distinctive AMP families. Furthermore, we summarize the regulatory pathways of AMP production through classical signaling pathways and additional pathways associated with Nitric Oxide, insulin-like signaling, and hormones. This review advances our understanding of AMPs as guardians in insect immunity systems and unlocks a gateway to insect AMP resources, facilitating the use of AMPs to address food safety concerns.
Assessing Animal Models to Study Impaired and Chronic Wounds
Authors: Saeed Shayan , Martins-Green Manuela
Published: March 2024

Impaired healing wounds do not proceed through the normal healing processes in a timely and orderly manner, and while they do eventually heal, their healing is not optimal. Chronic wounds, on the other hand, remain unhealed for weeks or months. In the US alone, chronic wounds impact ~8.5 million people and cost ~USD 28–90 billion per year, not accounting for the psychological and physical pain and emotional suffering that patients endure. These numbers are only expected to rise in the future as the elderly populations and the incidence of comorbidities such as diabetes, hypertension, and obesity increase. Over the last few decades, scientists have used a variety of approaches to treat chronic wounds, but unfortunately, to date, there is no effective treatment. Indeed, while there are thousands of drugs to combat cancer, there is only one single drug approved for the treatment of chronic wounds. This is in part because wound healing is a very complex process involving many phases that must occur sequentially and in a timely manner. Furthermore, models that fully mimic human chronic wounds have not been developed. In this review, we assess various models currently being used to study the biology of impaired healing and chronic non-healing wounds. Among them, this paper also highlights one model which shows significant promise; this model uses aged and obese db/db−/− mice and the chronic wounds that develop show characteristics of human chronic wounds that include increased oxidative stress, chronic inflammation, damaged microvasculature, abnormal collagen matrix deposition, a lack of re-epithelialization, and the spontaneous development of multi-bacterial biofilm. We also discuss how important it is that we continue to develop chronic wound models that more closely mimic those of humans and that can be used to test potential treatments to heal chronic wounds.
Non-Thermal Plasma Reduces HSV-1 Infection of and Replication in HaCaT Keratinocytes In Vitro
Authors: Sutter Julia , Brettschneider Jascha , Wigdahl Brian , Bruggeman Peter J. , Krebs Fred C. , Miller Vandana
Published: March 2024

Herpes simplex virus type 1 (HSV-1) is a lifelong pathogen characterized by asymptomatic latent infection in the trigeminal ganglia (TG), with periodic outbreaks of cold sores caused by virus reactivation in the TG and subsequent replication in the oral mucosa. While antiviral therapies can provide relief from cold sores, they are unable to eliminate HSV-1. We provide experimental results that highlight non-thermal plasma (NTP) as a new alternative therapy for HSV-1 infection that would resolve cold sores faster and reduce the establishment of latent infection in the TG. Additionally, this study is the first to explore the use of NTP as a therapy that can both treat and prevent human viral infections. The antiviral effect of NTP was investigated using an in vitro model of HSV-1 epithelial infection that involved the application of NTP from two separate devices to cell-free HSV-1, HSV-1-infected cells, and uninfected cells. It was found that NTP reduced the infectivity of cell-free HSV-1, reduced viral replication in HSV-1-infected cells, and diminished the susceptibility of uninfected cells to HSV-1 infection. This triad of antiviral mechanisms of action suggests the potential of NTP as a therapeutic agent effective against HSV-1 infection.