bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards consistency in dietary pattern scoring: standardising scoring workflows for healthy dietary patterns using 24-h recall and two variations of a food frequency questionnair
Authors: Arnoldy Lizanne , Gauci Sarah , Lassemillante Annie-Claude M. , Verster Joris C. , Macpherson Helen , Minihane Anne-Marie , Scholey Andrew , Pipingas Andrew , White David J.
Published: January 2024

Healthy dietary patterns such as the Mediterranean diet (MeDi), Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) have been evaluated for their potential association with health outcomes. However, the lack of standardisation in scoring methodologies can hinder reproducibility and meaningful cross-study comparisons. Here we provide a reproducible workflow for generating the MeDi, DASH and MIND dietary pattern scores from frequently used dietary assessment tools including the 24-h recall tool and two variations of FFQ. Subjective aspects of the scoring process are highlighted and have led to a recommended reporting checklist. This checklist enables standardised reporting with sufficient detail to enhance the reproducibility and comparability of their outcomes. In addition to these aims, valuable insights in the strengths and limitations of each assessment tool for scoring the MeDi, DASH and MIND diet can be utilised by researchers and clinicians to determine which dietary assessment tool best meets their needs.
Do Preliminary References Increase Public Support for European Law? Experimental Evidence from Germany
Authors: Cheruvu Sivaram , Krehbiel Jay N.
Published: January 2024

Explanations for the successful expansion and consolidation of the European Union and its legal system have long emphasized the importance of domestic courts’ sending preliminary references to the Court of Justice. Key to many of these theoretical accounts is the claim that domestic courts are better equipped than the Court of Justice to compel national governments to comply with EU law. Integrating insights from the comparative judicial politics literature into the context of the EU's preliminary references system, we provide a theoretical and empirical foundation for this claim by arguing that incorporating domestic courts into the EU legal process enhances public support for expansive judicial interpretations of EU law. We go on to argue, however, that this transfer of legitimacy depends on citizens’ views of the national and European courts. We support our argument with evidence from a preregistered survey experiment fielded in Germany.
When and How Proactivity Impacts Vitality
Authors: Pingel Ruta , Fay Doris
Published: January 2024

Abstract: Employee proactivity has been shown to have beneficial and detrimental effects on employees’ well-being. Drawing on self-determination theory, the present research identifies a moderator shaping these effects and sheds light on the process through which proactivity benefits well-being. Results of a time-lagged study with two measurement points ( N = 120) separated by a biweekly interval revealed that the relationship between proactivity and vitality depends on the level of autonomous motivation. Specifically, when autonomous motivation for proactivity was high, there was a positive association, when autonomous motivation was low, the relationship was negative. Notably, the direct effect of proactivity on vitality 2 weeks later was nonsignificant. A laboratory experiment ( N = 68) replicated the positive effect of autonomously motivated proactivity on vitality and identified autonomy need satisfaction as the mechanism through which this beneficial effect unfolds. Our research emphasizes the role of autonomous motivation in shaping the well-being outcomes of proactivity.
Detection of viable oral bacteria of the patient on the surgical mask of dentists
Authors: Gund Madline Priska , Naim Jusef , Lang Janina , Hannig Matthias , Gärtner Barbara , Halfmann Alexander , Boros Gabor , Rupf Stefan
Published: January 2024

Introduction and aim

Bioaerosols contaminate the personal protective equipment (PPE), especially masks. The PPE harbors microorganisms from various sources. However, no previous studies have investigated the specific sources of bacteria found on used masks and their correlation with those from the treated patient.

Setting, design, material and methods

Intraoral samples from the patient were collected prior to dental aerosol-producing treatments using a nylon flock fiber swab. After treatment, the practitioner’s mask was imprinted onto agar plates.

Main outcome methods

Following cultivation, colony forming units were counted and identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). After the samples were analyzed, the intraoral samples as well as the mask samples were assessed for the presence of identical species, which were subsequently quantified.

Results

126 treatments were included. One species match occurred most frequently (26.2%), followed by two (11.9%%) and three or more (3.97%). In the intraoral samples, Neisseria subflava occurred most often, within mask samples Staphylococcus epidermidis were detected most. Staphylococcus aureus could be cultivated three times more often in intraoral samples than on the mask.

Discussion and conclusion

Oral microorganisms originating from the patient’s oral cavity can be found on the outside of masks. When using PPE during treatments, it should therefore always be in mind that potentially pathogenic microorganisms may land on the mask becoming a source of for itself.
HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis
Authors: Yang Kexi , Li Juntao , Zhu Jinghan , Chen Yuqi , He Yuxin , Wang Jiayu , Shen Kanger , Wang Kun , Shi Tongguo , Chen Weichang
Published: January 2024

HOOK3, a member of the human hook microtubule-tethering protein family, has been implicated in the progression of cancer. However, the role of HOOK3 in the pathogenesis of gastric cancer (GC) remains incompletely understood. In this study, we investigated the expression of HOOK3 protein in GC tissues using immunohistochemistry (IHC). The findings of our study indicate that the expression levels of HOOK3 in GC tissues were relatively low. Furthermore, a significant negative association was seen between HOOK3 expression and the prognosis of patients with GC. The suppression of HOOK3 resulted in a notable increase in the proliferation, migration, invasion, and survival of GC cells. Conversely, the overexpression of HOOK3 had the opposite impact, reducing these cellular processes. Moreover, in vivo tests have shown evidence that the overexpression of HOOK3 significantly inhibited the formation of tumors and the spread of GC cells to the lungs. In a mechanistic manner, the analysis of RNA-seq data demonstrated that the knockdown of HOOK3 resulted in a notable increase in the expression of vascular endothelial growth factor A (VEGFA) in GC cells. Furthermore, the upregulation of VEGFA counteracted the impacts of HOOK3 upregulation on the proliferation, migration, invasion, and survival of GC cells. Furthermore, it was revealed that specificity protein 1 (SP1) exhibited the ability to bind to the promoter region of VEGFA. Moreover, the overexpression of SP1 successfully counteracted the inhibitory impact of HOOK3 overexpression on the expression of VEGFA in GC cells. In summary, the results of our study indicate that HOOK3 has a role in inhibiting the growth, migration, invasion, and survival of GC cells by modulating the SP1/VEGFA pathway. These findings contribute significant knowledge to our understanding of the underlying mechanisms involved in the development of GC.
Recent progress in photoreactive crosslinkers in polymer network materials toward advanced photocontrollability
Authors: Masai Hiroshi , Nakagawa Tomoki , Terao Jun
Published: January 2024

Photochemically adaptable polymer materials, which change shape and physical properties under light irradiation, are widely used in the fields of medicine, electronics, and engineering due to their precise and remote processability. This processability is attributed to the photocleavage of chemical bonds introduced into the polymer materials. In particular, the efficient photolytic cleavage of the crosslinking points in the network induces rapid softening and degradation of the materials. Recently, diverse designs of light-responsive units have been developed to fabricate various photocontrollable materials with low-energy, rapid, and reversible photoreactivity. Furthermore, multiple stimuli-responsive materials have been demonstrated to control photodegradation reaction rates and photoreactivity by combining light with another stimulus, leading to advanced photocontrollable capabilities. This paper reviews the recent progress in developing photochemically adaptable polymer network materials by designing photoresponsive units, focusing on the chemical structures of cleavable moieties.
Variable swelling behavior of and drug encapsulation in a maleimide-modified hyaluronic acid nanogel-based hydrogel
Authors: Yabuuchi Kohei , Katsumata Toru , Shimoboji Tsuyoshi , Hashimoto Yoshihide , Kimura Tsuyoshi , Akiyoshi Kazunari , Kishida Akio
Published: January 2024

Hyaluronic acid (HA) has garnered much attention in the development of novel hydrogels. Hydrogels, as drug delivery systems, are very important in tissue engineering applications. In this study, we developed a novel HA nanogel containing a cholesterol and maleimide derivative (HAMICH) and its corresponding crosslinked hydrogel (HAMICH gel) to encapsulate drugs for their subsequent release. HAMICH gels self-assemble into nanoparticles via hydrophobic interactions. Dynamic light scattering analysis of HAMICH revealed that the particle size tended to decrease with increasing degree of cholesterol moiety substitution. The HAMICH gel was prepared through a Michael addition reaction between HAMICH and pentaerythritol tetra(mercaptoethyl)polyoxyethylene. The concentration of HAMICH needed for gelation depends on the degree of cholesterol moiety substitution; the higher the substitution degree is, the greater the concentration of HAMICH needed. The HAMICH gel exhibited less swelling and a smaller volume change than the gel with an unmodified cholesterol moiety in phosphate-buffered saline (pH 7.4). The HAMICH gel displayed enhanced peptide and protein trapping abilities without hydrogel swelling, suggesting its potential as a HA hydrogel for biomedical applications.
Anomalous enhancement of thermoelectric power factor in multiple two-dimensional electron gas system
Authors: Uematsu Yuto , Ishibe Takafumi , Mano Takaaki , Ohtake Akihiro , Miyazaki Hideki T. , Kasaya Takeshi , Nakamura Yoshiaki
Published: January 2024

Toward drastic enhancement of thermoelectric power factor, quantum confinement effect proposed by Hicks and Dresselhaus has intrigued a lot of researchers. There has been much effort to increase power factor using step-like density-of-states in two-dimensional electron gas (2DEG) system. Here, we pay attention to another effect caused by confining electrons spatially along one-dimensional direction: multiplied 2DEG effect, where multiple discrete subbands contribute to electrical conduction, resulting in high Seebeck coefficient. The power factor of multiple 2DEG in GaAs reaches the ultrahigh value of ~100 μWcm−1K−2at 300 K. We evaluate the enhancement rate defined as power factor of 2DEG divided by that of three-dimensional bulk. The experimental enhancement rate relative to the theoretical one of conventional 2DEG reaches anomalously high (~4) in multiple 2DEG compared with those in various conventional 2DEG systems (~1). This proposed methodology for power factor enhancement opens the next era of thermoelectric research.
The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell
Authors: Lee Jeong Han , Perez-Flores Maria C. , Park Seojin , Kim Hyo Jeong , Chen Yingying , Kang Mincheol , Kersigo Jennifer , Choi Jinsil , Thai Phung N. , Woltz Ryan L. , Perez-Flores Dolores Columba , Perkins Guy , Sihn Choong-Ryoul , Trinh Pauline , Zhang Xiao-Dong , Sirish Padmini , Dong Yao , Feng Wayne Wei , Pessah Isaac N. , Dixon Rose E. , Sokolowski Bernd , Fritzsch Bernd , Chiamvimonvat Nipavan , Yamoah Ebenezer N.
Published: January 2024

The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents.
Neuromorphic hardware for somatosensory neuroprostheses
Authors: Donati Elisa , Valle Giacomo
Published: January 2024

In individuals with sensory-motor impairments, missing limb functions can be restored using neuroprosthetic devices that directly interface with the nervous system. However, restoring the natural tactile experience through electrical neural stimulation requires complex encoding strategies. Indeed, they are presently limited in effectively conveying or restoring tactile sensations by bandwidth constraints. Neuromorphic technology, which mimics the natural behavior of neurons and synapses, holds promise for replicating the encoding of natural touch, potentially informing neurostimulation design. In this perspective, we propose that incorporating neuromorphic technologies into neuroprostheses could be an effective approach for developing more natural human-machine interfaces, potentially leading to advancements in device performance, acceptability, and embeddability. We also highlight ongoing challenges and the required actions to facilitate the future integration of these advanced technologies.
NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations
Authors: Yang Liang , Ruan Zifeng , Lin Xiaobing , Wang Hao , Xin Yanmin , Tang Haite , Hu Zhijuan , Zhou Yunhao , Wu Yi , Wang Junwei , Qin Dajiang , Lu Gang , Loomes Kerry M. , Chan Wai-Yee , Liu Xingguo
Published: January 2024

Aging in mammals is accompanied by an imbalance of intestinal homeostasis and accumulation of mitochondrial DNA (mtDNA) mutations. However, little is known about how accumulated mtDNA mutations modulate intestinal homeostasis. We observe the accumulation of mtDNA mutations in the small intestine of aged male mice, suggesting an association with physiological intestinal aging. Using polymerase gamma (POLG) mutator mice and wild-type mice, we generate male mice with progressive mtDNA mutation burdens. Investigation utilizing organoid technology and in vivo intestinal stem cell labeling reveals decreased colony formation efficiency of intestinal crypts and LGR5-expressing intestinal stem cells in response to a threshold mtDNA mutation burden. Mechanistically, increased mtDNA mutation burden exacerbates the aging phenotype of the small intestine through ATF5 dependent mitochondrial unfolded protein response (UPRmt) activation. This aging phenotype is reversed by supplementation with the NAD+ precursor, NMN. Thus, we uncover a NAD+ dependent UPRmt triggered by mtDNA mutations that regulates the intestinal aging.
Higher local Ebola incidence causes lower child vaccination rates
Authors: Das Upasak , Fielding David
Published: January 2024

Ebola is a highly infectious and often fatal zoonotic disease endemic to West and Central Africa. Local outbreaks of the disease are common, but the largest recorded Ebola epidemic originated in Guinea in December 2013, spreading to Liberia, and Sierra Leone in the following year and lasting until April 2016. The epidemic presented a serious challenge to local healthcare systems and foreign aid agencies: it degraded services, caused the loss of healthcare professionals, disrupted the economy, and reduced trust in modern healthcare. This study aims to estimate the extent to which variation in one long-term measure of the quality of local healthcare (the child vaccination rate) is a consequence of local variation in the intensity of the epidemic. Applying a “difference-in-differences” model to household survey data from before and after the epidemic, we show that in 2018–2019, overall rates of vaccination for BCG, DPT, measles, and polio are lower in Guinean and Sierra Leonean districts that had a relatively high incidence of Ebola; statistical analysis indicates that this is a causal effect. The effects of the epidemic on access to healthcare have been local effects, at least in part.
Decoration of Ag nanoparticles on CoMoO4 rods for efficient electrochemical reduction of CO2
Authors: Ray Schindra Kumar , Dahal Rabin , Ashie Moses D. , Bastakoti Bishnu Prasad
Published: January 2024

Hydrothermal and photoreduction/deposition methods were used to fabricate Ag nanoparticles (NPs) decorated CoMoO4 rods. Improvement of charge transfer and transportation of ions by making heterostructure was proved by cyclic voltammetry and electrochemical impedance spectroscopy measurements. Linear sweep voltammetry results revealed a fivefold enhancement of current density by fabricating heterostructure. The lowest Tafel slope (112 mV/dec) for heterostructure compared with CoMoO4 (273 mV/dec) suggested the improvement of electrocatalytic performance. The electrochemical CO2 reduction reaction was performed on an H-type cell. The CoMoO4 electrocatalyst possessed the Faraday efficiencies (FEs) of CO and CH4 up to 56.80% and 19.80%, respectively at  − 1.3 V versus RHE. In addition, Ag NPs decorated CoMoO4 electrocatalyst showed FEs for CO, CH4, and C2H6 were 35.30%, 11.40%, and 44.20%, respectively, at the same potential. It is found that CO2 reduction products shifted from CO/CH4 to C2H6 when the Ag NPs deposited on the CoMoO4 electrocatalyst. In addition, it demonstrated excellent electrocatalytic stability after a prolonged 25 h amperometric test at  − 1.3 V versus RHE. It can be attributed to a synergistic effect between the Ag NPs and CoMoO4 rods. This study highlights the cooperation between Ag NPs on CoMoO4 components and provides new insight into the design of heterostructure as an efficient, stable catalyst towards electrocatalytic reduction of CO2 to CO, CH4, and C2H6 products.
A systematic review and meta-analysis of the relationship between magnesium levels and malaria severity
Authors: Kotepui Kwuntida Uthaisar , Mahittikorn Aongart , Wilairatana Polrat , Masangkay Frederick Ramirez , Kotepui Manas
Published: January 2024

Magnesium is associated with Plasmodium infections and malaria severity. This systematic review and meta-analysis was conducted to synthesize the link between Plasmodium infections and magnesium levels for improved clinical guidance and therapeutic interventions in malaria-affected regions. A systematic literature search was conducted across multiple databases, including ProQuest, Scopus, Embase, Ovid, MEDLINE, PubMed, and Google Scholar. The risk of bias in the selected studies was assessed using the Joanna Briggs Institute critical appraisal tools. A thematic synthesis was employed to demonstrate the magnesium levels across selected studies, for analyzing and grouping based on geographic regions, age demographics, and clinical manifestations of malaria. Meta-analyses determined differences in magnesium levels between individuals with malaria, uninfected controls, and patients with different clinical severities of malaria. The effect sizes from individual studies were pooled using the random-effects model. Out of 2533 records identified, 13 studies were included in the review. The thematic synthesis revealed complex and varied results, with studies showing different magnesium levels in malaria patients across different geographies, age groups, and clinical presentations. The meta-analysis indicated elevated magnesium levels in malaria patients compared with uninfected controls (P < 0.01, Hedges’ g: 1.94, 95% CI 0.86–3.03, I2: 98.38%, 9 studies). No statistically significant difference was observed in magnesium levels between patients with severe and nonsevere malaria (P: 0.34, Hedges’ g: 0.62, 95% CI − 0.64–1.88, I2: 91.46%, 2 studies). A significant increase in magnesium levels was seen in patients with malaria who died compared with those who survived (P < 0.01, Hedges’ g: 0.39, 95% CI 0.13–0.64, I2: 3.39%, 3 studies). This systematic review and meta-analysis presented relationship between magnesium levels and malaria. While the meta-analysis indicated a general trend of increased magnesium levels in patients with malaria, the substantial heterogeneity and instability of the results hint toward a rich yet uncharted territory requiring more research depth. The intricate interplay between magnesium levels and malaria beckons a multidimensional approach in future studies.
Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy
Authors: Nakashima Ryuta , Hosoda Ryusuke , Tatekoshi Yuki , Iwahara Naotoshi , Saga Yukika , Kuno Atsushi
Published: January 2024

It has been reported that autophagic activity is disturbed in the skeletal muscles of dystrophin-deficient mdx mice and patients with Duchenne muscular dystrophy (DMD). Transcriptional regulations of autophagy by FoxO transcription factors (FoxOs) and transcription factor EB (TFEB) play critical roles in adaptation to cellular stress conditions. Here, we investigated whether autophagic activity is dysregulated at the transcription level in dystrophin-deficient muscles. Expression levels of autophagy-related genes were globally decreased in tibialis anterior and soleus muscles of mdx mice compared with those of wild-type mice. DNA microarray data from the NCBI database also showed that genes related to autophagy were globally downregulated in muscles from patients with DMD. These downregulated genes are known as targets of FoxOs and TFEB. Immunostaining showed that nuclear localization of FoxO1 and FoxO3a was decreased in mdx mice. Western blot analyses demonstrated increases in phosphorylation levels of FoxO1 and FoxO3a in mdx mice. Nuclear localization of TFEB was also reduced in mdx mice, which was associated with elevated phosphorylation levels of TFEB. Collectively, the results suggest that autophagy is disturbed in dystrophin-deficient muscles via transcriptional downregulation due to phosphorylation-mediated suppression of FoxOs and TFEB.
Comprehensive genomic exploration of class III peroxidase genes in guava unravels physiology, evolution, and postharvest storage responses
Authors: Gull Shaista , Ali Muhammad Moaaz , Ejaz Shaghef , Ali Sajid , Rasheed Majeeda , Yousef Ahmed Fathy , Stępień Piotr , Chen Faxing
Published: January 2024

Peroxidases (PRXs) play multifaceted roles in plant growth, development, and stress responses. Here, we present a comprehensive analysis of the PRX gene family in guava, a globally significant fruit. In the guava genome, we identified 37 PRX genes, a number lower than that of Arabidopsis, suggesting a distinctive gene family expansion pattern. Phylogenetic analysis unveiled close relationships with Arabidopsis PRXs, with 12 PgPRX genes forming ortholog pairs, indicating a specific expansion pattern. Predictions placed most PRX proteins in the chloroplast and extracellular regions. Structural analysis of PgPRX proteins revealed commonalities in domain structures and motif organization. Synteny analysis underscored the dynamic role of segmental duplication in the evolution of guava's PRX genes. We explored the dynamic expression of PgPRX genes across guava tissues, exposing functional diversity. Furthermore, we examined changes in peroxidase levels and gene expressions during postharvest fruit storage, providing insights for preserving fruit quality. This study offers an initial genome-wide identification and characterization of Class III peroxidases in guava, laying the foundation for future functional analyses.
Analysis of vitamin D receptor binding affinities of enzymatically synthesized triterpenes including ambrein and unnatural onoceroids
Authors: Ueda Daijiro , Matsuda Natsu , Takaba Yuka , Hirai Nami , Inoue Mao , Kameya Taichi , Abe Tohru , Tagaya Nao , Isogai Yasuhiro , Kakihara Yoshito , Bartels Florian , Christmann Mathias , Shinada Tetsuro , Yasuda Kaori , Sato Tsutomu
Published: January 2024

Onoceroids are a rare family of triterpenes. One representative onoceroid is ambrein, which is the main component of ambergris used as a traditional medicine. We have previously identified the onoceroid synthase, BmeTC, in Bacillus megaterium and succeeded in creating ambrein synthase by introducing mutations into BmeTC. Owing to the structural similarity of ambrein to vitamin D, a molecule with diverse biological activities, we hypothesized that some of the activities of ambergris may be induced by the binding of ambrein to the vitamin D receptor (VDR). We demonstrated the VDR binding ability of ambrein. By comparing the structure–activity relationships of triterpenes with both the VDR affinity and osteoclastic differentiation-promoting activity, we observed that the activity of ambrein was not induced via the VDR. Therefore, some of the activities of ambergris, but not all, can be attributed to its VDR interaction. Additionally, six unnatural onoceroids were synthesized using the BmeTC reactions, and these compounds exhibited higher VDR affinity than that of ambrein. Enzymatic syntheses of onoceroid libraries will be valuable in creating a variety of bioactive compounds beyond ambergris.
Efficient synthesis of novel thiadiazolo[2,3-b]quinazolin-6-ones catalyzed by diphenhydramine hydrochloride-CoCl2⋅6H2O deep eutectic solvent
Authors: Korbekandi Mehri Moeini , Mohammadpoor-Baltork Iraj , Moghadam Majid , Tangestaninejad Shahram , Mirkhani Valiollah , Notash Behrouz
Published: January 2024

In this research, a new Lewis acid-based deep eutectic solvent (LA-DES) was synthesized using diphenhydramine hydrochloride and CoCl2·6H2O, (2[HDPH]:CoCl42−), and identified by FT-IR and 1HNMR techniques. The physicochemical properties of this LA-DES, such as thermal behavior, thermal stability, and solubility in common solvents were also investigated. The catalytic ability of 2[HDPH]:CoCl42− was ascertained in the efficient synthesis of a novel array of thiadiazolo[2,3-b]quinazolin-6-one scaffolds via a one-pot three-component reaction of dimedone/1,3-cyclohexanedione, aldehydes, and 5-aryl-1,3,4-thiadiazol-2-amines/3-(5-amino-1,3,4-thiadiazol-2-yl)-2H-chromen-2-one under solvent-free conditions. This catalyst was also successfully utilized for the synthesis of mono- and bis-thiadiazolo[2,3-b]quinazolin-6-ones from dialdehydes or bis-1,3,4-thiadiazol-2-amine. The simplicity of enforcement, short reaction time, avoidance of toxic organic solvents, scalability of the synthesis procedure, excellent atom economy, high reaction mass efficiency, and low E-factor are other outstanding advantages of this newly developed method. Furthermore, due to the convenient recovery and reuse of LA-DES, this protocol is economically justified and environmentally friendly.
Exploring the pathogenesis and key genes associated of acute myocardial infarction complicated with Alzheimer’s disease
Authors: Liu Chaosheng , Pan Fuzhi , Sun Zhiyu , Chen Ziyu , Wang Junjie
Published: January 2024

Despite mounting evidence linking Acute Myocardial Infarction (AMI) to Alzheimer’s disease (AD), the shared mechanism of these two conditions’ occurrence remains unclear. This research aims to delve deeper into the molecular process of the occurrence of the two diseases. We retrieved the gene expression profiles of AD (GSE5281) and AMI (GSE66360) from the Gene Expression Omnibus database. Then, a total of 22 common differentially expressed genes (DEGs) including one downregulated gene and 21 upregulated genes were chosen for further analysis. Following the discovery of the common DEGs between AMI and AD, we performed protein–protein interaction analysis and hub gene identification analysis. Next, ten important hub genes were identified. Additionally, the key genes were identified by the least absolute shrinkage and selection operator and support vector machine‐recursive feature elimination and multivariable logistic regression analysis. The BCL6 was identified to be the most connected with AMI and AD. Finally, the BCL6 gene was validated in the GSE40680 (AMI) and GSE122063 (AD) datasets. Our research indicates that AMI and AD share a comparable pathophysiology. The Hub genes, especially BCL6, were essential in developing AMI and AD. In addition, these hub genes and shared pathways can offer fresh perspectives for additional mechanism investigation.
The Mediator kinase module enhances polymerase activity to regulate transcriptional memory after heat stress in Arabidopsis
Authors: Crawford Tim , Siebler Lara , Sulkowska Aleksandra , Nowack Bryan , Jiang Li , Pan Yufeng , Lämke Jörn , Kappel Christian , Bäurle Isabel
Published: January 2024

Plants are often exposed to recurring adverse environmental conditions in the wild. Acclimation to high temperatures entails transcriptional responses, which prime plants to better withstand subsequent stress events. Heat stress (HS)-induced transcriptional memory results in more efficient re-induction of transcription upon recurrence of heat stress. Here, we identified CDK8 and MED12, two subunits of the kinase module of the transcription co-regulator complex, Mediator, as promoters of heat stress memory and associated histone modifications in Arabidopsis. CDK8 is recruited to heat-stress memory genes by HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2). Like HSFA2, CDK8 is largely dispensable for the initial gene induction upon HS, and its function in transcriptional memory is thus independent of primary gene activation. In addition to the promoter and transcriptional start region of target genes, CDK8 also binds their 3ʹ-region, where it may promote elongation, termination, or rapid re-initiation of RNA polymerase II (Pol II) complexes during transcriptional memory bursts. Our work presents a complex role for the Mediator kinase module during transcriptional memory in multicellular eukaryotes, through interactions with transcription factors, chromatin modifications, and promotion of Pol II efficiency.
Multifunctional molecularly imprinted nanozymes with improved enrichment and specificity for organic and inorganic trace compounds
Authors: Ge Zhanyi , Zhao Yilin , Li Jiayi , Si Zhaobo , Du Wenbo , Su Haijia
Published: January 2024

The Fe3O4 molecularly imprinted peroxidase nanozymes were developed by modelling the substrate channels of natural enzymes with controlled selectivity.
Magnetic micromotors crossing lipid membranes
Authors: Ramos Docampo Miguel A. , Hovorka Ondrej , Städler Brigitte
Published: January 2024

Nano/micromotors are self-propelled particles that show enhanced motion upon being triggered by a stimulus.
Electroosmotic flow spin tracers near chemical nano/micromotors
Authors: Cui Donghao , Yan Zuyao , Chen Xiaowen , Liu Jiayu , Wang Wei
Published: January 2024

We report the first experimental observation of tracer spinning in place alongside chemically powered individual nano/micromotors.
Palladium catalyzed remote-meta-C–H functionalization of aniline scaffolds
Authors: Srinivas Dasari , Satyanarayana Gedu
Published: January 2024

Here, we report on a microwave-assisted accelerated meta-C–H olefination of aniline derivatives using a simple aliphatic end-on nitrile assembly. Notably, the protocol shows broad substrate compatibility with remarkable regio-selectivity.
Correction: A combined crystallography and DFT study on ring-shaped cucurbit[n]urils: structures, surface character, and host–guest recognition
Authors: Zhu Guoxun , You Ao , Song Huacan , Li Zhengquan
Published: January 2024

Correction for ‘A combined crystallography and DFT study on ring-shaped Cucurbit[n]urils: structures, surface character, and host–guest recognition’ by Guoxun Zhu et al., RSC Adv., 2022, 12, 10014–10019, https://doi.org/10.1039/D2RA00797E.
Porous organic framework membranes based on interface-induced polymerisation: design, synthesis and applications
Authors: Liu Lin , Yu Ruihe , Yin Liying , Zhang Ning , Zhu Guangshan
Published: January 2024

Interfacial polymerisation has become an important method for the preparation of porous organic framework (POF) membranes. We summarise the strategies and applications in forming POF membranes induced by different interfaces.
Advancing Rice Yield Forecasting and Crop Assessment in Kazakhstan’s Kyzylorda Region: A Multisource Satellite Data Approach
Authors: Bekmukhamedov Nurlan , Karabkina Natalya , Kurbanova Rekhangul , Koshim G. Asyma , Yegizbayeva Asset , Ilyas Sana
Published: January 2024

The monitoring and prediction of rice yields are essential across various domains, including agriculture, environmental conservation, ecology, agricultural insurance, and land resource management. The central districts of Kazakhstan’s Kyzylorda region, encompassing 70% of the total rice cultivation area, are of particular importance for ensuring national food security. This study focuses on the central Kyzylorda region, specifically the Syrdarya, Zhalagash, and Karmakshi districts, which serve as the primary hub for rice cultivation in Kazakhstan. The primary objective is to advance remote sensing techniques tailored to evaluate crop conditions and forecast rice yields, accounting for the region’s unique soil and climatic attributes. The research methodology involves comprehensive analysis of Sentinel-2 and Landsat-8 satellite data, harmonized with ground-truth information. This analysis encompasses the latest rice crop data for 2020 and precise sowing dates. Extensive field surveys were conducted to gather crucial data on growth, development, crop health, and productivity under specific agrometeorological conditions. The study provides a detailed flowchart outlining the sequential processing of remote sensing data and ground-based information, with a primary focus on forecasting rice yields in the central Kyzylorda districts for 2020. Rigorous satellite data analysis established robust correlations between the Normalized Difference Vegetation Index (NDVI) and various crop conditions, directly linked to rice yield, with high precision (R2 values ranging from 0.82 to 0.91). Validation exercises, cross-referencing satellite data with real-time field data, further enhanced accuracy. The research outcomes have extensive applications, benefiting agriculture, environmental preservation, ecology, insurance, statistics, and land management. This study underscores the significance of addressing critical challenges across various sectors through multifaceted findings.
Trash Collection Gadget: A Multi-Purpose Design of Interactive and Portable Solution for Beach Cleanup
Authors: Jin Xiayi
Published: January 2024

Beach pollution has become a pressing environmental concern with increased human activities. It calls for innovative solutions that can not only address the problem but also engage and educate individuals in the long run. Herein, a prototype robotic cleanup system was introduced in this project in response to such a requirement. The project aims to design and develop a playful and user-friendly robotic system to accompany families and children during beach visits while actively gathering land rubbish or marine debris. The device is made up with three primary components, including a control system, a collection system, and a rubbish storage container. The control system receives operation instruction from cell phones through Bluetooth connection to direct the moving mode of the device. The collection system is equipped with plastic spikes and conveyor belts that can pick up and deposit trash into the storage container. The entire system is featured to be a portable “beach buddy” that only takes up one cubic foot of space, allowing for easy transportation and operation. The performance of the beach buddy was evaluated both on the land and in the water, showing promise for collection of rubbish under various circumstances. By combining entertainment, portability, and environmental consciousness, the design of robotic “beach buddy” in this study is expected to promote both ecological awareness and a sense of responsibility among users.
Flight Simulation Assessment of a Novel FW-MR Hybrid Agriculture Drone
Authors: Mazlan Mukhriz , Nasir Rizal E.M. , Ma’arof M.I.N.
Published: January 2024

Agriculture is a sector in Malaysia where the usage of drones has been widespread throughout seeding, surveying, and crop spraying. It has been well known that the current usage of drones in pineapple farms specifically in Malaysia can be further improved upon. This novel design combines the long flight capabilities of fixed-wing aircraft with the efficiency of the common multirotor UAV hence it is a hybrid of both. The methodology of this research uses flight simulations to extract the data concerned with its flying quality such as coefficient of lift, drag, and moments. This research evaluates the longitudinal stability within the computationally simulated data extracted from a mission-profiled flight. The aim of this is the understanding of practical uses as well as the modification needed prior to manufacture.
Considering the Beacon technology, a Green and eco-friendly revolution in the Moroccan Commercial Malls for a proximity marketing strategy
Authors: Lemsieh Hafsa , Abarar Ibtissam
Published: January 2024

Proximity marketing is becoming an important strategy that enables linking retailers and consumers to enhance the customer experience. This marketing action aims to consider the customer location to provide a significant information at the right moment and space. Beacon technology is a real advancement in this domain of study. Beacons are a small device-wireless communication that allow detecting the presence of a person in the store through the low-energy Bluetooth signals and deliver impressive offers to visitors’ mobile phone from their area or product proximity inside the store. The objective is to offer an in time individual experience and interact efficiently with visitors. This paper presents a quantitative empirical study that aims to analyze the results of embodying the beacon technology in the large Moroccan commercial malls. For this, an online questionnaire was prepared to assemble consumers’ feedback regarding the use of this proximity marketing action. The results of this empirical study will help notifying marketers in their strategies by coming up with quantitative data collection that analyzes the customer perception of this technology, consequently, Moroccan malls may consider this relevant proximity marketing strategy in the future decisions to improve the customer experience for a long-term loyalty.
Review on the Development of Wing-In-Ground Crafts
Authors: Pua’at Afifi.A , Zhahir Amzari , Ahmad Mohamed Tarmizi , Hassan Aziz
Published: January 2024

This paper focuses on the development of Ground Effect Craft (GEC). The ultimate objective of this paper is to comprehensively outline all publicly disclosed and well-known GECs. The scope of this paper encompasses a review of the design challenges and architectures associated with GECs that have been prevalent for more than 60 years. It delves into research, development, and enhancements of existing GECs throughout their history. In conclusion, considering current technological advances, GECs present substantial opportunities and potential to evolve into a viable mode of transportation, effectively bridging the gap between aircraft and ships. The incentive to overcome the economic challenges associated with fabricating and operating GECs is worthwhile, encouraging exploration and development toward a commercially viable GEC.
Moroccan perceptions of environmental volunteering
Authors: Abdulwahid Asma , Abdelghani Chafik
Published: January 2024

This study aimed to discover the perceptions of Moroccans about environmental volunteering; the study is an understudied area of research that would be one of the valuable researches for practitioners in the voluntary sector who wish to create tailored programs. We found that understanding the prevailing views on environmental volunteering is not always straightforward; it is a relationship between humans about their natural environment, which is shaped by local beliefs, and socioeconomic, religious, and cultural factors. Environmental volunteering in Morocco involves conducting environmental education, workshops in schools, and environmental protection, as well as participating in projects carried out by teacher organizations for environmental education and sustainable development.
Review of Implementing the Internet of Things (IoT) for Robotic Drones (IoT Drones)
Authors: Hajjaj Sami Salama Hussen , Moktar Muhammad Hafizuddin , Weng Leong Yeng
Published: January 2024

Drone and the Internet of Things are different technologies, actively utilised and implemented across various fields. Connectivity is the difference between the IoT drone and the regular drone. IoT drones can receive and transmit data and command signals in real-time while being controlled through the IoT network. By implementing both drone and IoT, the flying IoT (IoT-Drone) is built as a new form of IoT device. This work improves how to use the drone effectively in many aspects; data transferring, data collecting, real-time monitoring, and control. With the emergence of the Internet of Things, Artificial Intelligence, and advanced communication, the IoT drone technology has been utilized in many fields, especially in agriculture and inspection, and discussed in smart cities, logistic delivery, and the military. This paper reviews the IoT drone implementation in those fields and reviews the researchers’ discussion and studies on IoT drone optimization.
Performance Analysis of Heat Recovery System for a Turbofan Engine using Intercooler and Recuperator via Aspen Plus
Authors: Chua I.C, W , Saadon S.
Published: January 2024

Global warming and climate change have been major problems in the present world. Greenhouse gas emissions contribute to global warming in which carbon dioxide being the best known. The aviation sector (excluding aerospace) has contributed to a total of 49.4 billion tons of carbon dioxide emission in 2016 alone. A solution to curb the increase of greenhouse gases has been proposed to temporarily solve this problem while future technological advancements occur. Having a heat recovery system by using heat exchangers in the engine helps to not only improves the performance of the engine but to also reduce temperature of the exhaust gases that will be eliminated as waste heat into the atmosphere. The main objective of the introduction of intercoolers and recuperators is to reduce the thrust specific fuel consumption whilst increasing the thrust and reducing emissions. This research thesis focuses on the analysis of intercooling and recuperation within the aspects of thermodynamics to be integrated into a typical turbofan engine. The analysis will be conducted via process simulation software – Aspen Plus V11 and the data from the software will be exported to Microsoft Excel for post-processing and graph visualization. Three main objectives of the study are to determine whether compression work will be reduced, studying the increase of thrust and performance of the engine with the positioning of heat exchangers and the improvement of TSFC with the integration of heat exchangers. For the first objective, it has been proven that there is a reduction in compression work for the recuperated engine of 7.64% but there is a 13.17% increase in compression work for the intercooled engine. For the second objective, thrust increased in both recuperated and intercooled cycles with 1.14% and 1.31% for the recuperated and intercooled cycles, respectively. Finally for the third objective, a decrease in TSFC for both recuperated and intercooled cycles show that both the heat recovery systems have an improvement of TSFC.
Smart Strategies for Sustainable Aquaculture Development in Morocco: Regulatory Framework, Organizational Innovations, and Socio-economic Implications
Authors: Er-rousse Omar , Qafas Ahlam
Published: January 2024

International conventions on the law of the sea and obligations for the management of marine living resources are fairly recent (United Nations Convention on the Law of the Sea, known as Montego Bay, 1982). Currently, we see that developing countries are suppliers of fish, crustaceans and molluscs to developed countries, which has an impact on their socio-economic level. Our study aims to recognize the conventions and regulatory texts in force (international and national) that affiliate aquaculture with sustainable development; carry out a socio-economic approach to the aquaculture activities mentioned in Morocco; and summarize the challenges facing the aquaculture sector. Based on the pilasters of sustainability, the cornerstone of the blue economy, there is coherence between regulatory scales, while lack of management skills, dysfunctions due to lack of governance and their impact on the environment condition sustainable development. This requires vigilance during the Decade of Ocean Science for Sustainable Development (2021-2030). The Decade of Oceanography for Sustainable Development is a decade of the blue economy’s growth with its three pillars of sustainability: environmental, economic and social. When talking about sustainable development, it is important to understand the similarities between the blue and ocean economies in order to enact environmentally sustainable and inclusive public policies against climate change.
Exploring and Strengthening Energy Concepts through Computer Simulation in Educational Institutions
Authors: Bentaleb Meriem , Boudine Hommane , Slimani Khadija , Tayebi Mohamed
Published: January 2024

In a world increasingly dependent on energy, understanding its fundamental concepts becomes paramount. As we navigate complex global challenges related to sustainability and innovation, educating the younger generation about energy is crucial. Computer simulation learning has emerged as a pivotal tool in optimizing teaching methodologies, particularly when it comes to comprehending and mastering energy-related concepts. This innovative approach provides an immersive experience, allowing students to practically and interactively explore the intricate principles of energy. Focused on the industrial technology associated with energy, this study delves into the application of computer simulation to enhance the understanding of adolescents aged 13 to 16. A sample of students, spanning three classes, underwent electrical circuit manipulation tests utilizing simulation software. Analysis of the results, employing Pearson’s correlation coefficient, revealed a significant enhancement in the comprehension of energy concepts through simulation-based learning. By enabling students to visualize and experiment with various energy-related scenarios.