bluuebunny/crossref_metadata_2025 huggingface dataset:
Potensi FuMA stem cells, kombinasi fukoidan dan Bone Marrow Stem Cells (BMSCs), sebagai penatalaksanaan mutakhir pada Infark Miokard Akut
Authors: Sista Satyarsa Agung Bagus , Arta Suryantari Sang Ayu , Arya Gumilang Putu Gupta , Ayu Dewi Ni Nyoman
Published: April 2020

Introduction: Acute myocardial infarction (AMI) is the leading cause of death worldwide. One of the causes of high morbidity and mortality is progressive and irreversible nature of the disease and current treatments are still not optimal in resolving these problems. Thus, this paper aims to describe the potential effect of combination of fucoidan and bone marrow stem cells (namely FuMA stem cells) as the novel management of AMI.Method: The method used in our paper was literature searching by including the keywords of AMI, BMSCs, and fucoidan.Result: Fucoidan from brown seaweed has shown a great potential effect as anti-inflammatory, anti-coagulant, anti-atherogenic, anti-oxidant, and anti-fibrotic. It limits the infarct area and increases SDF-1, CXCR4 and Akt expression as well as LVEF. However, fucoidan has not been able to regenerate cardiomyocyte cells in AMI. It takes a combination of BMSCs that have been shown to prevent the expansion of infarction area and improve post-infarction function.Conclusion: Thus, FuMA stem cells hold a great potential novel therapy for AMI. Further studies are needed to unveil the potential of FuMA stem cells in AMI management.
The risk of atopic dermatitis in post-term gestational age at Sanglah Hospital Denpasar: A preliminary study
Authors: Ardinata Made , Kumara Wati Ketut Dewi , Artana Wayan Dharma , Santosa Hendra , Witarini Komang Ayu
Published: April 2020

Backgrounds: Several studies reported that Atopic Dermatitis (AD) increases with gestational age. Prolong dominancy of Th2 activity during gestation might contribute to the risk of atopic disease in infancy or beyond the period. This study aimed to evaluate the risk AD in post-term gestational age.Methods: A prospective observational study was conducted among 73 living births at Sanglah Hospital Denpasar from December 2015 to January 2016 period. Infants were classified into 2 such as exposed (post-term) and non exposed (term and preterm) group. Parents-follow up by phone was carried out in 1 until 2 months interval. The study was finished once AD diagnosed, subject died or lost to follow up. Statistical analysis was carried out using SPSS ver. 20 software whereas P-value > 0.05 was considered significant.Results: About 20 (233%) infants were preterm, 36 (49.3%) a term, and 17 (23,3%) post-term. The median value of follow up duration was 28 (14-35) days. Based on AD, there were total 24 cases which divided into 15(62.5%), 8(33.3%) and 1(4.17%) cases of AD in post-term, aterm, and preterm respectively. The incidence rate of AD in post-term was 88.2% while in non-post-term the incidence rate was 16.1%. The relative risk (RR) of AD in post-term was 5.47 (95% CI 2.94-10.23; P = 0.001)Conclusion: Post-term is 5.47 times more likely to develop AD compared with aterm and preterm infant. In addition, the incidence rate of AD in post-term infant was 88.2% at Sanglah Hospital Denpasar
Persentase remaja pengguna rokok pada klien klinik napza di Rumah Sakit Umum Pusat Sanglah Denpasar
Authors: Purnamasari Ade , Diniari Ni Ketut Sri , Wahyuni Anak Ayu Sri
Published: April 2020

Introduction: Smoking is a major cause of preventable death worldwide, and is a major risk factor for six of the eight leading causes of death, namely ischemic heart disease, cerebrovascular disease, lower respiratory infections, chronic pulmonary obstructive disease, tuberculosis and lung cancer. This study aims to determine the percentage of cigarette use, the characteristics of age for the first time smoking, and the percentage of use of cigarettes, alcohol, and other substances in PTRM Sandat clients Sanglah Hospital.Method: This study was conducted at PTRM Sandat Sanglah Hospital in August to October 2015 using a descriptive cross-sectional design.Results: The results of this study showed 100% of respondents smoked at a young age with 76% of respondents having a daily smoking status. The data obtained showed that the majority of smoking clients in the age of 13-15 years were 56% and 42% smoked at 16-19 years old. Judging from alcohol consumption, all study respondents consumed alcohol and 74% of respondents consumed marijuana. Of the total respondents, 60% consumed benzodiazepine and 62% of respondents took amphetamines. As many as 66% of respondents took halucinogen drugs and were responsive who consumed opioids by 36%.Conclusion: Percentage of cigarette use in PTRM Sandat clients Sanglah Hospital one hundred percent positive using cigarettes with most having daily smoking status and all starting smoking in their teens. Smoking on PTRM Sandat clients at Sanglah General Hospital when teenagers become gateways for other drug use.
Korelasi kadar leptin serum terhadap derajat penyakit dermatitis atopik
Authors: Ariwangsa Gde Ngurah Arya , Wardhana Made , Rusyati Luh Made Mas
Published: April 2020

Background: Atopic dermatitis (AD) is a chronic and residual skin inflammatory disease in which the symptoms include intense itching, chronic exacerbations and remissions, with multifactorial etiologies. The role of leptin in DA is closely related to polarization of T cells towards Th1 cells resulting in the release of pro-inflammatory cytokines.Methods: A cross-sectional study was conducted among 30 atopic dermatitis patients at Sanglah General Hospital in the period of July-August 2018. The leptin examination was carried out using the ELISA method. Data analysis were performed using SPSS version 25.0 software with the Spearman correlation test to determine the relationship between levels of serum leptin and the severity of atopic dermatitis based on SCORAD.Results: Most of the respondents were females (66.7%) with an average leptin level was 25.75 + 18.21 pg/dL. The results showed a significant negative correlation between the level of serum leptin and the severity of DA (SCORAD) (r: -0.127; p: 0.043). However, there was a significant positive correlation between pH of the skin and SCORAD (r: 0.810 and p: <0.001).Conclusions: There is a negative correlation between level of serum leptin and SCORAD but it has a strong positive correlation between the pH of the skin and SCORAD.
Perbedaan kadar antitrombin III pada sepsis neonatal kultur darah positif dan kultur darah negatif
Authors: Siridian Prima Indah , Loesnihari Ricke , Tjipta Guslihan Dasa
Published: April 2020

Background: Fetal and neonatal hemostatic systems are dynamic. Coagulation and inhibitors of coagulation factors are progressively synthesized by the fetus which begins after 34 weeks of pregnancy and at the initial hours after birth. The neonatal hemostatic system generally shifts towards hypercoagulability. During sepsis, this hypercoagulability is exacerbated by an imbalance of coagulation and inhibitors of coagulation factors including antithrombin III. This study aimed to determine differences of antithrombin III levels in neonatal sepsis positive blood cultures (proven sepsis) and negative blood cultures (unproven sepsis).Methods: The subjects of this study were 26 patients of neonatal sepsis, which consisted of 13 positive blood cultures and 13 negative blood cultures. Levels of antithrombin III were examined by chromogenic methods. Examination of blood cultures of gram-positive bacteria using manual method and gram-negative bacteria using semiautomatic method. Data analysis uses an independent t test.Results: Antithrombin III levels in neonatal sepsis patients positive blood culture (73,23 Â± 21,62) didnâ€™t differ significantly compared to negative blood cultures (65,63 Â± 20,81) with p = 0,370 (p> 0,05). The bacterial pattern that caused neonatal sepsis were Staphylococcus sp. (84,6%), CoNS (81,8%), Staphylococcus aureus (18,2%)}, Salmonella spp (7,7%) and Klebsiella pneumoniae ssp pneumoniae (7,7%). The sensitivity pattern of Staphylococci to cefoxitin to determine resistence, found 5 Methicillin-resistant Staphylococci (MRS) and 1 Meticillin-resistant Staphylococcus aureus (MRSA). Conclusion: There were no significant differences of antithrombin III levels in neonatal sepsis positive blood cultures and negative blood cultures.
Laparoscopic pyelolithotomy in treating extra-renal pelvic calculi at Sanglah General Hospital: a case series
Authors: Kurniawan AS Made , Santosa Kadek Budi
Published: April 2020

Background: This study aims to describe our initial experience in treating extra-renal pelvic calculi using retroperitoneal laparoscopic pyelolithotomy techniques in Urology Division, Department of Surgery, Sanglah hospital, Bali.Case Description: There were seven patients enrolled with extra-renal pelvic calculi in this study whereas two of them accompanied by calyx inferior secondary stones. All the patients underwent retroperitoneal laparoscopic pyelolithotomy with DJ Stent applied. The operating time was improving in each procedure, with average time was 110 minutes, VAS at the first day post-operative was 1-2, a drain was removed on the second day, one of them was extended until the sixth day, most patients was discharged on postoperative day 3. All patients were stented for 3 to 4 weeks; The stents were removed with office cystoscopy. All patients were stone free on follow-up imaging.Conclusion: Retroperitoneal laparoscopic pyelolithotomy is a safe alternative for the management of pelvic renal calculi with minimal post-operative pain and shorter length of stay.
Perbedaan parameter analisa gas darah (AGD) pada mixing sampel sesuai dan tidak sesuai standar Clinical and Laboratory Standards Institute (CLSI)
Authors: Kusuma Diah Ayu , Rachmawati Banundari
Published: April 2020

Pendahuluan: Analisis Gas Darah (AGD) merupakan bagian penting untuk mendiagnosis dan mengelola status oksigenasi dan keseimbangan asam basa pasien. Instalasi Gawat Darurat (IGD) dan perawatan intensif (ICU) menggunakan AGD sebagai bagian tak terpisahkan dari penilaian status klinis pasien. Dalam pemeriksaan AGD khususnya, pengumpulan dan penanganan spesimen darah arteri yang tidak tepat dapat menghasilkan hasil yang keliru. Pada pemeriksaan AGD salah satu kesalahan pra-analitik adalah mixing sampel yang tidak sesuai standar. Tujuan penelitian ini adalah membuktikan adanya perbedaan hasil parameter AGD antara sampel yang dilakukan mixing sesuai dengan standar Clinical and Laboratory Standards Institute (CLSI) dan yang tidak sesuai standar CLSI.Metode: Ini merupakan studi observasional analitik potong lintang. Subjek penelitian adalah pasien usia 25-50 tahun yang dirawat di ICU RSUP Dr. Kariadi Semarang dan dilakukan pemeriksaan AGD. Analisis statistik menggunakan paired T-test dan Wilcoxon test. Dikatakan terdapat perbedaan bermakna apabila nilai p < 0.05.Hasil: Terdapat perbedaan bermakna pada parameter pO2 (p < 0.001), SO2 (p Â Â Â Â Â < 0.001), Â dan natrium (p = 0.038) antara sampel yang dilakukan mixing sesuai standar CLSI dan tidak sesuai standar CLSI. Tidak terdapat perbedaan bermakna pada parameter pH, pCO2, Hb, Hct, HCO3-, dan BE antara sampel yang dilakukan mixing sesuai standar CLSI dan tidak sesuai standar CLSI.Simpulan: Terdapat perbedaan bermakna pada parameter untuk menilai status oksigenasi antara mixing sampel sesuai dengan CLSI dan tidak sesuai CLSI. Mixing sampel yang benar diperlukan untuk mendapatkan hasil yang dapat dipertanggungjawabkan.
Hubungan resting metabolic rate (RMR) dan komposisi tubuh dengan kadar HbA1c pada obesitas
Authors: Lovita Inggrid , Hendrianingtyas Meita , Triwardhani Ria
Published: April 2020

Background: Obesity occurs due to an imbalance intake and energy expenditure. The cause of obesity is low energy expenditure whereas the resting metabolic rate (RMR) is the largest component of energy expenditure of the body. The factors that influence RMR are body composition, age, sex and hormonal status. Body composition measured as fat mass and free fat mass (FFM). Body fat increase in obesity can cause insulin resistance which will increase blood glucose levels. This study aims to determine the correlation between RMR and body composition (fat mass and FFM) with HbA1c levels increase as a parameter of diabetes mellitus in obesity.Methods: Cross sectional study design to 38 subjects young adults obese. Resting metabolic rate and body composition (fat mass and FFM) measured with Omron Karada scan HBF 375. HbA1c measured with ion-exchange HPLC method. Statistical analysis using the Spearmanâ€™s correlation test (p<0.05)Result: HbA1c mean of 5.4% is still a normal value of HbA1c. There were no correlation between RMR and HbA1c (p = 0.768), fat mass with HbA1c (p = 0.102) and FFM with HbA1c (p = 0.843).Conclusion: RMR and body composition (fat mass and FFM) are not associated with HbA1c levels in obese young adults.
Perbedaan kadar ureum, natrium, kalium dan klorida pra dan pasca hemodialisa pada pasien dengan penyakit ginjal kronik
Authors: Anwar Syaiful , Ariosta Ariosta
Published: April 2020

Background: Chronic Kidney Disease (CKD) is a progressive and irreversible damage to kidney function (GFR < 60 ml / minute / 1.73 m2). The function of the kidneys is to maintain stability, electrolyte level, osmolarity of extracellular fluid and excrete products such as urea, uric acid, and creatinine. CKD disrupts electrolyte fluid balance and uremia, thus requiring renal replacement therapy in the form of dialysis or kidney transplantation. Different levels of urea, sodium, potassium, and chloride pre- and post-hemodialysis can be a consideration for the management of hemodialysis in CKD patients. This study aimed to determine the difference in urea, sodium, potassium, and chloride pre- and post-hemodialysis in CKD patients.Method: This was a cross-sectional analytical observational study of pre- and post hemodialysis conducted from September to October 2018. Normally distributed data were analyzed using the paired t-test, while data that were not normally distributed were analyzed using the Wilcoxon test. It was considered significant when the p-value was < 0.05.Results: There was a total of 50 patients consisting of 30 males (60.0%) and 20 females (40.0%). The mean age of the patients was 51.10 Â± 7.48 years. The level of pre-hemodialysis urea (161.96 Â± 53.80 mg / dL) was significantly different from post-hemodialysis (120.70 Â± 40.84 mg / dL). The level of pre-hemodialysis sodium (134.5 mmol / L) was significantly different from post-hemodialysis (140 mmol / L). The level of pre-hemodialysis potassium (5.6 mmol / L) was significantly different from post-hemodialysis (4.6 mmol / L). The level of pre-hemodialysis chloride (100 mmol / L) was significantly different from post-hemodialysis (96 mmol / L). Conclusion: There was a significant difference in urea, sodium, potassium, and chloride between pre- and post-hemodialysis (p < 0.05).
Hubungan petanda inflamasi dan hemoglobin pada obesitas di Fakultas Kedokteran Universitas Diponegoro periode Mei-September 2018
Authors: Wijayanti Emelia , Retnoningrum Dwi , Hendrianintyas Meita
Published: April 2020

Introduction: Obesity is one of global epidemic health problems. Obesity has been suggested to be associated with a state of chronic low-grade inflammation, which is characterized by abnormal cytokine production, increased acutephase reactants and activation of inflammatory signaling pathways. NLR (neutrofil to lymphocyte ratio) a simple and reliable indicator of inflammation, have been reported to be associatied with metabolyc syndrom, insulin resitence, and obeity in more study. Ferritin is a marker of inflammation contribute in obesity, and have been reported that ferritin is a marker of inflammation rather than iron status in overweight and obese people. Relationship between anemia and obesity may be due to fat a ccumulation and chronic inflammation in adipose tissue can be decreased iron absorbtion.Methods: Cross-sectional study of 50 obesity subject, based on Riskesdas criteria, on Mei â€“ September 2018. Marker of inflammation is ferritin serum was measured by ELISA (enzyme linked immunosorbent assay), and NLR and haemoglobin was perfomed from haematology analyzer. Spearman test was perfomed for analyzing data with p <0,05 was significantResults: No correlation between NLR and haemoglobin, r= 0,067 and p= 0,642, and significant strong positive correlation between ferritin and haemoglobin, r= 0,630 and p < 0,000.Conclusion: There was no correlation between NLR and haemoglobin, and there was significant strong positive correlation between ferritin and haemoglobin in obesity. Future research need to observe with evaluate hepcidin, other iron status parameter and marker of inflammation.
Hubungan jenis packed red cell (PRC) yang ditransfusikan dengan reaksi transfusi febrile non haemolytic transfusion reaction (FNHTR)
Authors: Kamilah Dinda , Widyaningrum Dian
Published: April 2020

Background: One of the components of blood cells are often used for transfusions is Packed Red Cell (PRC). Blood components transfusion may continues with rapid or delayed transfusion ractions. The most transfusion reactionsÂ  was fever (55%) or febrile non haemolytic transfusion reaction (FNHTRs). The cause of these events is associated with allogenic leucocytes (the ability to differentiate self cells and non-self cells based on the human leukocyte antigen (HLA) on the cell surface) and release of proinflammatory cytokines such as IL-1, IL-6, IL-8, TNFÎ±, Cell-free DNA (cfDNA), histone and the duration of blood storage. Methods: Cross-sectional study on 41.177 patients who received a PRC transfusion with the FNHTR transfusion reaction in Hospital Blood Bank Dr. Kariadi Semarang, duringÂ  January 2017 to July 2018. Pearson Chi Square test for expected frequency more than 5. The Kolmogorov smirnov and Shapiro-wilk test were used to evaluate normality of the data. Mann-Whitney test to analyze the difference, p < 0,05 was considered as significant.Results: The incidence of FNHTR was lower in patients who received leukodepleted PRC (11 patients) than non leukodepleted PRC (124 patients). There were differences in body temperature in the incidence of FNHTR between the two groups 38.10 C (38-39) VS 38.40 C (38 â€“ 39.2) with p = 0,046.Conclusions:There were relationship between the incidence of FNHTR with the transfusion with leukodepleted PRC and non leukodepleted PRC.
The oxidative-stress level determine patientâ€™s outcomes with a severe head injury at Sanglah General Hospital, Denpasar, Indonesia
Authors: Wirawan I Made Bagus , Golden I Nyoman , Niryana I Wayan
Published: April 2020

Background: In secondary brain injury, oxidative stress will occur due to a balance disorder between pro-oxidants with antioxidants. The antioxidant activity that is often used to assess oxidative stress, such as malondialdehyde (MDA), is superoxide dismutase (SOD) and glutathione peroxidase (GPx). This study aims to evaluate the level of oxidative stress, reflected by the MDA serum level and SOD level to determine the outcomes of patients with severe head injury.Method: A cross-sectional analytic study was conducted among 40 patients with severe head injury within 24 hours post-trauma at Emergency Ward, Surgery Department, Sanglah General Hospital Denpasar from January - June 2017. MDA and SOD levels were assessed using ELISA at Clinical Pathology Laboratory, Sanglah General Hospital. Data were analyzed using SPSS ver. 16 software. Results: This study found significant differences on elevated MDA levels (p-value < 0.05) in patients who died or had a persistent vegetative state, patients with severe disability and those with a good recovery/moderate disability. The statistical analysis also found a significant difference in MDA serum levels among patient with severe disability and patients with a good recovery/moderate disability (P=0,028). Meanwhile, there was no significant correlation between SOD serum levels and patients outcome (P>0.05).Conclusion: Increased MDA serum levels is a significant factor in predicting outcomes of patients with severe head injury.
Hubungan kadar leptin terhadap parameter trombosit pada pasien dengan obesitas
Authors: Fajaryani Dwi , Hendrianingtyas Meita , Retnoningrum Dwi
Published: April 2020

Background: Obesity is excessive and abnormal fat accumulation thus harmful to health. Increase in body mass index (BMI) in obesity, also accompanied by increase hormon which synthesized and released by adipose tissue informs the brain for controlling hunger and food intake that is Leptin. Leptin plays a role in chronic inflammatory process of obesity. Leptin receptor was detected in human platelets and high concentration of leptin reported to promote platelet aggregation. The platelet parameters examination is a cheap, easy, and routinly done in daily basis, which consist of platelet counts, mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT), which indicates platelet proliferation. The aim of research was to look the relationship of leptin with thrombocyte parameter in obesity people.Methods: Cross sectional study of 45 obese adults, based on RISKESDAS criteria Â with Â BMI>27, on Mei-September 2018 was done. Venous blood collected in EDTA and plain tube. The EDTA sample was used for complete hematological examination to obtain platelet parameters by Hematology analayzer with impendace method. Serum from plain tube used for leptin examination was measured by ELISA. Data were analyzed by Pearson and Spearman correlation test. P-value < 0,05 was consideres as significant.Results: There is no correlation between leptin and platelet count (r=0,051, p=0,740), MPV (r=0,021, p=0,891), PDW (r=-0,093, p=0,541),Â  P-LCR (r=0,082,Â  p=0,593), and PCTÂ  (r=0,079, p=0,605).Â Conclusion: There is no correlation between leptin and platelet parameters in obesity. Further studies need to be done with adding another characteristic such as inflammation markers, metabolic syndrome parameters and platelet activation
Gambaran pengetahuan, sikap, dan perilaku tentang vaginal hygiene terhadap kejadian keputihan patologis pada siswi kelas 1 di SMA Negeri 1 Denpasar periode Juli 2018
Authors: Pradnyandari Ida Ayu Cintya , Surya I Gede Ngurah Harry Wijaya , Aryana Made Bagus Dwi
Published: April 2020

Introduction: Leucorrhea was a prolonged problem that has been experienced by women, especially teenagers. Teenagers are part of a population that are at risk. Pathological leucorrhea which is not prevented and handled properly can cause various disease and have a fatal end. This research aimed to know how were the knowledge, attitudes, and behavior of vaginal hygiene towards pathological leucorrhea phenomenon on first grade female students in 1 Senior High School of Denpasar City. Method: This research was a descriptive study with cross-sectional method. The research subject was 106 first grade female students in 1 Senior High School of Denpasar City. The data were collected on 26th of July 2018. This research used primary data from the questionnaire that had been filled out.Result: The results showed that the level of knowledge about vaginal hygiene was 99,9% good and 0,1% bad. The level of attitudes about vaginal hygiene was 100% good. The level of behavior about vaginal hygiene was 98,2% good and 1,8% bad.Conclusion: Most of the student in Senior High School 1 Denpasar have a good level of knowledge, attitude, and behavior towards vaginal hygiene.
The correlation between serum magnesium level and blood pressure in patient with chronic kidney disease
Authors: Yanti Maulida Devi , Suromo Lisyani Budipradigdo
Published: April 2020

Background: Increased blood pressure is one of the complications from hemodialysis in Chronic Kidney Disease (CKD) patients. Magnesium is an electrolyte which is a calcium antagonist in regulating blood pressure. This study aims to prove the correlation of serum magnesium level with blood pressure in CKD patientsMethods: A cross-sectional study was conducted on 30 CKD patients in Dr. Kariadi Hospital, Semarang during Septemberâ€“October 2018. The serum magnesium level was measured with spectrophotometry method, blood pressure with a sphygmomanometer. Statistical analysis used Pearson and Spearman correlation test.Result: There is a significant correlation between serum magnesium level and systolic blood pressure with p< 0,001 and r=-0,737 and correlation between serum magnesium level and diastolic blood pressure with p=0,011 and r=-0,457Conclusion: There is a strong negative correlation of serum magnesium level with systolic blood pressure and moderate negative correlation of serum magnesium level with diastolic blood pressure in this study. Further studies are needed to analyze the influential factors of blood pressure.
Turnaround time pelayanan darah rujukan di bank darah RSUP Dr. Wahidin Sudirohusodo sebelum dan sesudah implementasi sistem informasi manajemen darah
Authors: Simbolon Erika Rosaria , Muhiddin Rachmawati , Arif Mansyur
Published: April 2020

Background: Blood Information Management System or SIMERAH is the system information which allows blood bank officers at Dr. Wahidin Sudirohusodo hospital to check blood supply in Blood Transfusion Unit. Before SIMERAH implementation, referral blood service was done by directly giving the patientâ€™s family a blood request form to PMI without blood supply information. Referral blood service after SIMERAH implementation requires blood bank officers to order blood before referring patients to PMI. This study aims to compare Turnaround Time (TAT) of referral blood before and after SIMERAH implementation.Methods: The population of this study has been all patients receiving referral blood service to PMI since January 2017 to June 2017 (before SIMERAH implementation) and January 2018 to June 2018 (after SIMERAH implementation). Statistical analysis conducted were descriptive statistics and paired t-test.Results: The average TAT at Dr. WahidinSudirohusodo Hospitalâ€™s Blood Bank before SIMERAH implementation was 6,10 hours. The average TAT after SIMERAH implementation was 4,37 hours. There was 25,2 % decrease of average TAT after SIMERAH implementation at Dr. Wahidin Sudirohusodo Hospitalâ€™s Blood Bank. There were significant decreases of TAT in January, February, March, May, and June (p<0.05). There was a decrease of TAT in April but not statistically significant (p>0.05).Conclusion: SIMERAH was significantly decrease TAT in Dr. Wahidin Sudirohusodo Hospitalâ€™s Blood Bank.
Faktor risiko yang mempengaruhi length of stay pasien kanker solid dengan febrile neutropenia pasca kemoterapi neoadjuvant/terapeutik di Ruang Isolasi RSUP Sanglah, Bali
Authors: Natawidjaja Ronald , Manuaba Ida Bagus Tjakra Wibawa , Adiputra Putu Anda Tusta
Published: April 2020

Background. Febrile neutropenia is a common complication in patient undergoing chemotherapy. Length Of Stay (LOS) is an important marker for disease severity and use of medical resources in febrile neutropenia. This study was done to find the risk factor affecting length of stay in solid cancer patients with febrile neutropenia post neoadjuvant/therapeutic chemotherapy.Method. This is a case control study without matching. Age â‰¥ 60 years, (Absolute Neutrofil Count) ANC level < 1,5 Î¼L , comorbid,Â  Hb level <10 gr/dl, and albumin < 3 gr/dl, were related to LOS ( â‰¤ 5 days and > 5 days). Univariate (chi square) and multivariate (logistic regression) were used to analyse the statistic.Results. Forty six patients met inclusion-exclusion criteria were included in this study. ANC level in all patients were < 1,5 Î¼L (100%). Hb level <10 gr/dl is statistically significant (P<0.05), whereasÂ  age â‰¥ 60 years, and comorbid, albumin level < 3 gr/dl were not is statistically significant (P>0.05).Conclusion. Hb level < 10 gr/dl is the risk factor for LOS > 5 days in solid cancer patients with febrile neutropenia post neoadjuvant/therapeutic chemotherapy.
Karakteristik kanker kulit di Rumah Sakit Umum Pusat Sanglah Denpasar tahun 2015-2018
Authors: Wardhana Made , Darmaputra I Gusti Nyoman , Adhilaksman I Gde Nengah , Pramita Nyoman Yoga Maya , Maharis Ricky Fernando , Puspawati Made Dwi , Karmila I Gusti Ayu Agung Dwi , Praharsini I Gusti Agung Ayu , Indira I Gusti Ayu Agung Elis , Suryawati Nyoman
Published: April 2020

Latar belakang: Prevalesi kanker kulit semakin meningkat di seluruh dunia. Walaupun insiden tertinggi pada kelompok berkulit putih, namun mengetahui epidemiologi dan tren penyakit dari kanker kulit diperlukan agar dapat menentukan pencegahan dan penanganan yang tepat.Tujuan: Untuk mengetahui karakteristik kanker kulit pada pasien yang telah dilakukan skin flap di Departemen Dermatologi dan Venereologi RSUP Sanglah.Metode: Penelitian ini merupakan studi deskriptif retrospektif dari catatan medis semua penderita kanker kulit yang memperoleh tindakan skin flap sejak Januari 2015 sampai dengan Desember 2019. Sampel diambil melalui total sampling. Karakteristik yang tercatat meliputi jenis kanker, jenis kelamin, umur, tipe kulit, pekerjaan, dan jenis flap yang dilakukan. Data yang terkumpul dianalisis secara deskriptif dengan program SPSS Ver21.Hasil: Terdapat 41 pasien kanker kulit yang memperoleh tindakan skin flap, terdiri dari 43,9% (n=16) BCC, 54,6% (n=10) melanoma, 21,9% (n=9) SCC, 9,8% (n=4) jenis kanker lain. Jenis flap yang umum digunakan yaitu simple advancement. Lokasi kanker paling umum ditemukan pada wajah dan kejadian kanker paling tinggi terjadi pada usia â‰¥50 tahun dan bekerja di luar ruangan.Simpulan: Kasus kanker tertinggi yaitu BCC dengan usia lebih dari 50 tahun dan bekerja di luar ruangan sebagai karakteristik paling umum pada semua kasus kanker.
Cognitive impairment in cerebral toxoplasmosis with pre-HAART HIV infection: a case report
Authors: Gunawijaya Dico , Kusumastuti Dian , Putra Widya , Ekasari Nurlina
Published: April 2020

Background: Dementia can be caused by infection in the central nervous system, primarily by HIV infection. The majority of the symptoms are short-term memory impairment accompanied by concentration and motoric deceleration. Opportunistic infections of Toxoplasma gondii often accompanies and aggravates the cognitive impairment that occurs.Case: Male, 55-year-old, complained by the family to be forgetful and hard to concentrate since last two weeks and got worse over time. The daily activities of the patient were often disturbed. The awareness, cranial nerve, motor function, sensory, and autonomic were within normal limits. Laboratory tests showed reactive IgG anti-toxoplasma (4520.00 IU / mL) and CD4 128 cells/ÂµL. A non-contrast head CT-Scan showed multiple ill-bordered hypodense lesions with broad peripheral edema in left cerebral hemispheres. Test of cognitive function with MoCA-Ina scored 13 and MMSE scored 19.Discussion: Dementia in HIV manifests as a collection of symptoms of cognitive and motor impairment that interfere with daily activities. The pathogenesis is thought to be caused by interactions with viral proteins and secondary inflammation. Chronic toxoplasmosis is associated with the incidence of dementia in HIV, which usually occurs when CD4 <200 cells/ÂµL. The underlying pathology of inflammation responsible for neurotransmitter modulation and oxidative stress. HAART administration related to a risk reduction of dementia in HIV. High penetrating antiretroviral lowers viral load better, so it can reliably reduce inflammation while slowing the progression of cognitive impairment.Conclusion: HIV infection often leads to dementia, either with or without opportunistic infections. Currently, HAART is the only therapy, accompanied by education and follow-up of the patient's cognitive function.
Uji efektivitas ekstrak etanol air kelopak bunga Hibiscus sabdariffa linn terhadap profil lipid tikus hiperlipidemia
Authors: Putra Ode Mahesa , Jawi I Made , Satriyasa Bagus Komang
Published: April 2020

Introduction: Cardiovascular disease is still the biggest cause of death in the world. Many factors that play a role in the development of this disease, one of them is Hiperlipidemia. The situation can be handled using conventional medicines, but there are concerns about the side effects of conventional medicines. Hibiscus Sabdariffa L. (roselle) is rich in polyphenols, anthocyanins, flavonoids which can be used as drugs for the prevention of cardiovascular diseases that have biological activities such as antihypertensive, antimutagenic, chemopreventive, antioxidant, anticonvulsant, anxiogenic, CNS-depressant, serotoninergic activity, reducing damage from oxidative liver, anti-inflammatory and hypoglycemic activity. This study aims to evaluate the effects of roselle ethanol extract as a hypolipidemic agent.Method: This study used an experimental design, using wistar mouse divided into five groups: C1 received aquadest intervention, C2 (simvastatin 0.2g / kg / day), I1 (100mg / kg / day roselle extract), I2 (200 mg / kg / day roselle extract), and I3 (300 mg / kg / day roselle extract) mice was given hypercholesterol oil feed for two weeks preceeding drugs intervention, then intervention was given for eight weeks and analyzed on mouse lipid profile component.Result: There were significant differences in total cholesterol, triglyceride, LDL, and HDL values among the intervention groups (p = 0.000). The lowest total cholesterol belonging to the C2 group (117.83 Â± 6.36) was followed by I3 (143.66 Â± 11.75), the lowest triglyceride belonging to the C2 group (284.83 Â± 7.46) was followed by I3 (306.84 Â± 8.61), the lowest LDL was owned by the group C2 (104.50 Â± 4.37), followed by I3 (120.50 Â± 2.42), the highest HDL belonging to the C2 group (44.80 Â± 3.16 followed by I3 group (38.02 Â± 3.40).Conclusion: The ethanol extract at 300mg / kg / day gave better improvement of lipid profile rather than roselle ethanol extract 100mg / kg / day, 200 mg / kg / day, and aquadest control, but still not able to provide better improvement than simvastatin.
Hubungan lingkar perut dengan kadar gula darah puasa pada mahasiswa Fakultas Kedokteran Universitas Udayana angkatan 2014
Authors: Wijaya Alvin , Wande Nyoman , Wirawati Ida Ayu Putri
Published: April 2020

Introduction: Diabetes Mellitus is a metabolic disease characterized by elevated blood sugar levels, either caused by a disturbance of insulin secretion, insulin resistance or both. Obesity is one of the risk factors of diabetes mellitus. The incidence of diabetes mellitus increases from year to year, but the data that discusses the association of risk factors with diabetes mellitus itself, especially obesity is minimum. The purpose of this study is to determine the association of abdominal circumference with fasting blood sugar levels at students of Udayana University Faculty of Medicine class of 2014.Method: This research is an analytical research conducted at Udayana University Faculty of Medicine Campus, Denpasar. Data obtained in the form of primary data in the form of abdominal circumference to see the status of obesity and fasting blood sugar to see the status of diabetes mellitus. Data were analyzed using SPSS program.Result: The results showed that there was not significant negative association between abdominal circumference with fasting blood sugar levels at Udayana University, Faculty of Medicine students class of 2014. However, this association is not statistically significant because diabetes mellitus influenced by many factors other than obesity. In addition, it can be seen that the characteristics of the population did not describe the population of diabetes mellitus or obesity, thus affecting associations that have been described in some literature and the concept of author thinking. But indeed the association of anthropometric risk factors (abdominal circumference) has a greater value than other risk factors.Conclusion: There was a negative correlation between abdominal circumference and fasting blood sugar but not significant statistically
The correlation between demography and clinical status based on WHO staging in MSM HIV patients at Bali Medical Centre
Authors: Nair Dhanesh Sukumar , Sutarsa I Nyoman , Sawitri A A Sagung , Kartika Sari Komang Ayu
Published: April 2020

Background: HIV stands for human immunodeficiency virus which is in the category of lentivirus (a subgroup of retrovirus) that causes HIV infection and can lead to acquired immunodeficiency syndrome (AIDS).Â  HIV affects specific cells of the immune system, called CD4 cells, or T cells. Over time, if left untreated, HIV can destroy so many of these cells that the body would not be able to fight off infections and disease. However, with proper medical care, HIV can be controlled. Treatment for HIV is called antiretroviral therapy (ART). It involves taking a combination of HIV medicines (called an HIV regimen) every day. Today, a person who diagnosed with HIV before the disease is far advanced and who gets and stays on ART can live a nearly normal lifespan.Aim: This study aims to investigate and analyze the predictors that influence WHO staging of homosexual MSM HIV patients treated at the BMC hospital in Bali. Indonesia, and to determine the factors that lead to differences in the WHO staging in MSM patients with HIV.Method: This study used a retrospective cohort method using secondary data from BMC Hospital. The sample population for this research is MSM HIV patients treated at the BMC hospital in Bali. Using the total sampling method yielded 271 samples.Result and Conclusion: the HIV incidence is a serious matter in Indonesia. One of the underlying factors for the delayed diagnosis of HIV is the lack of knowledge about the improved prognosis of early ARV treatment and a fear of being stigmatized by the community. Increased availability of HIV testing at hospitals, combined with enhanced knowledge of the prognosis of HIV treatment among crucial affected population, and the community at large and may improve earlier testing.
Pola Kuman dan Uji Kepekaan Antibiotik Pada Pasien Unit Luka Bakar RSUP Sanglah Periode 1 Januari 2016 - 1 Januari 2017
Authors: Junior I Wayan Jorden , Suka Adnyana I Made , Subawa I Wayan , Putri Vivi Paula
Published: April 2020

Background: Burns are a skin injury or injury caused by thermal that causes morbidity or mortality in patients, due to either heat or radiation, electrical and chemical reactions. In burns can occur bacterial growth that will cause an infection, both gram-positive bacteria and gram-negative bacteria. Necessary antibiotics in the treatment of infection by bacteria on burns. The incidence of burns is increasing from year to year, but data in Indonesia that discuss about the number of infections in burns and the use of antibiotics is still small.Aim: The study aims to determine the pattern of germs and antibiotic sensitivity test in patient burn unit at Sanglah Denpasar Hospital period January 2016 - January 2017.Method: This research is a descriptive descriptive cross sectional study conducted at Sanglah Denpasar General Hospital (RSUP). Data obtained in the form of secondary data of medical record of patient period January 2016 - January 2017. Data were analyzed by using SPSS program.Result: The results showed that from 63 patients, found 51.0% gram positive and 49.0% gram negative. In the positive gram found 8 species of bacteria with the most bacteria that is Staphylococcus aureus 15.87% and Strep Î² Haemolyticus 15.87% and gram negative found 3 types of bacteria with the highest number Pseudomonas aeruginosa 30.16%.Conclusion: Antibiotics with the highest resistance were found Amoxicillin 85.7%, Amoxicillin / Sulbactam 81.2% and Ampicillin 87.5% while the highest sensitivity antibotics were Amikacin 82.3%, Meropenem 75.0% and Linezolid 85.7% both on gram negative and gram positive.
Overview of drugs used for the treatment of hypertension for elderly patients in Sanglah General Hospital, Denpasar, Bali
Authors: Pathmanathan Archana Laxmi , Wardana I Nyoman Gede , Widianti I Gusti Ayu
Published: April 2020

Background: Hypertension is one of the most common diseases among elderly patients and it is also known as a silent killer. It could be due to excessive stress which causes the blood pressure to rise. The symptoms could appear, and people could go on for years without having any awareness of their disease. Aim: This research was conducted to determine the prevalence of hypertension cases of elderly patients and the drugs used as a treatment for hypertension in Sanglah Hospital, Denpasar, Bali. The research was carried on in the Sanglah Hospital, Denpasar, Bali as of January until June 2017. Method: In this study, a descriptive cross sectional study method was being used. Result: As the age increases, the number of individuals with hypertension increases. In gender, we could see that the female has a higher prevalence compared to male. In Sanglah, we found that the mostly given drugs are amlodipine and captopril for elderly people as this drug works effectively for the patients. Other drugs such as valsartan, furosemide, and bisoprolol are also offered to patients with hypertension depending on their associated diseases.
Perbandingan asupan makronutrien antara anak obesitas dengan normal pada siswa kelas 4-6 di Sekolah Dasar Santo Yoseph 2 Denpasar tahun 2017
Authors: Pradnyandari Ni Kadek Parswa Diah , Weta Wayan , Sawitri Anak Agung Sagung
Published: April 2020

Background: Childhood obesity is a disturbance of nutritional status in children with body mass index per age (BMI / U) exceeding> 1 standard deviation (SD) - 2 SD followed by unbalanced diet between intake and output accumulated in excess fat storage. There are some related factors for obesity such as unbalanced diet, lack of physical activity, and the environmental agents.Aim: This research aims to find out the correlation between macronutrient intake with child obesity in grade 4-6 students at Santo Yoseph 2 Denpasar Elementary School.Method: The study was an analytical cross-sectional design with 60 samples obtained from random sampling technique and interviewed with questioner (SQ-FFQ) and then measured the height and weight in the period March-August 2017. Those interview data was processed with Nutriesurvey9Â© and analyzed with SPSS.Result: 60 samples showed the dominant child obesity occurred in male gender (70.0%). The proportion of child obesity by age group was highest at 10-12 years (51.2%). Analysis of the relationship of macronutrient intake with child obesity was obtained for energy intake (p = 0.007), protein (p = 0.009) and fat (p = 0.018) intake was p < 0.05, while carbohydrate (p= 0.074) p > 0.05.Conclusion: This study shows that there is a statistically significant relationship between energy intake, protein, and fat with child obesity. Reversely, carbohydrates, there is no statistically significant association with childhood obesity.
Karakteristik Pasien Melanoma Maligna di Subbagian Bedah Onkologi RSUP Sanglah Tahun 2015-2016
Authors: Paramartha Gusti Ngurah Agung Adi , Niryana I Wayan , Adiputra Putu Anda Tusta
Published: April 2020

Background: Malignant melanoma (MM) is one of the skin malignancies derived from melanocyte cells. It is the most common cause of death, about 75% of all cases of skin cancer. Skin cancer is ranked fourth among the ten most common tumors in Bali.Aim: To know the characteristics of malignant melanoma patients in the sub-section of surgical oncology Sanglah Hospital Year 2015-2016.Method: This study is cross-sectional descriptive research conducted at Sanglah General Hospital in Denpasar. The data obtained in the form of secondary data, patient medical records, as of 2015 till 2016. Data were analyzed using the SPSS program.Result and Conclusion: The results showed that of 11 patients, incidence with the highest proportion of patients with age range 45-59 years number of 4 people (36.3%). The most top gender was women of 6 (54.5%). The highest subtype of Nodular Melanoma (NM) was 7 (63.6%).
Karakteristik ibu hamil dengan hiperemesis gravidarum di RSUP Sanglah Denpasar tahun 2017
Authors: Putri Luh Putu Mahatya Valdini , Wiradnyana A. A. Gede Putra , Darmayasa I Made
Published: April 2020

Background: Hyperemesis gravidarum is severe and over vomiting suffered as of early in pregnancy until 20 weeks of gestation. It may be harmful to the mother's health that can lead to weight loss of more than 5% and cause metabolic disorders. If it does not get proper treatment, it affects complications, even maternal and fetal deaths.Aim: The study aims to generalize the characteristic of pregnant patients who suffered hyperemesis gravidarum in Sanglah General Hospital.Method: This study is a cross sectional retrospective descriptive study with data retrieval on patient records for one year in 2017. This research was conducted at Space Cempaka Obstetrics and Medical Record Division Sanglah Hospital Denpasar.Result and Conclusion: pregnant women with hyperemesis gravidarum based on motherâ€™s age is highest experienced by pregnant women in the age group 20-35 years as many as 6 people (75%). Based on maternal age, pregnant women with hyperemesis gravidarum is highest experienced by pregnant women in the first trimester as many as 5 people (62.5%). As regard with the parity, Â it was highest experienced by pregnant women in the parity group nullipara as many as 4 people (50%). Moreover, maternal education is highest academic of pregnant women who have junior high and high school education, each of them as many as 3 people (37.5%). Based on the job status is highest experienced by pregnant women who work as many as 5 people (62.5%).
Prevalensi anemia pada ibu hamil di Puskesmas IV Denpasar Selatan Tahun 2015
Authors: Christian Yayang , Yasa I Wayan Putu Sutirta
Published: April 2020

Introduction: The prevalence of pregnant women with anemia is quite high in Indonesia up to 63.5%. Though anemia can cause various complications in the fetus and in pregnant women themselves. There is still no data supporting the prevalence of anemia in pregnant women in Bali Province. The purpose of this study was to find the prevalence of anemia in pregnant women in Bali Province, especially the city of Denpasar and complete the data library regarding anemia in preganancy in Indonesia.Method: The research used cross-sectional design, and secondary data collection from medical record of Primary Health Care IV South Denpasar year 2015.Result: Anemia pregnant women amounted to 166 of total 521 pregnant women with 31.9% prevalence, with an average of 43 cases of pregnant women with anemia every month.Conclusion: From the data obtained found the prevalence of pregnant women who suffer from anemia is still relatively high (31.9%).
Karakteristik penderita suspect demam berdarah dengue berdasarkan penurunan trombosit di Instalasi Rawat Inap Puskesmas Tegalalang I tahun 2014-1015
Authors: Wikrama Pande Komang Gede Bayu , Yasa I Wayan Putu Sutirta
Published: April 2020

Introduction: Dengue hemorrhagic fever are found in sub-tropic area and tropical. In the last 50 years, the incident has increased 30 times in the world. World Health Organitation with more than 70 % of the population are at risk of dengueÂ  lives in Asia. In the year 2007, Indonesia is a country of dengue hemorrhagic fever cases in Southeast Asia. Tegalalang is one of the district in Gianyar, which was having an increase in dengue hemorrhagic fever cases. This study aims to determine the characteristics of patients with suspected dengue fever based on a decrease in platelets in Inpatient Unit/Installation of the Puskesmas (Public Health Centre) Tegalalang I in 2014-2015.Methods: Study design using cross sectional model with secondary data from Puskesmas (Public Health Centre) Tegalalang I started in January 2014 to June 2015. In the medical records of observable characteristics by sex, age, occupation, and decreased thrombocytes count began from the day third, fourth, and fifth of the fever.Results: From 92 samples, 62% of men and 38% of women. The most samples between 15-24 years old and students are the most. Average thrombocytes on patients who began to be hospitalized on third day of the fever is 142.76x103/ml. Average thrombocytes on patients who began to be hospitalized on four days of the fever is 123.22x103/ml and average thrombocytes on patients who began to be hospitalized on fifth day of the fever is 88.67x103/ml.Conclusion: It can be concluded that the number of thrombocytes decrease in patients with suspected dengue hemorrhagic fever can occurs on in the fever on day third, fourth and fifth.