bluuebunny/crossref_metadata_2025 huggingface dataset:
LIKE GOLDEN APHRODITE: GRIEVING WOMEN IN THE HOMERIC EPICS AND APHRODITE'S LAMENT FOR ADONIS
Authors: Margulies Zachary
Published: January 2021

One of the more powerful recurring motifs in theIliadis that of the grief-stricken woman lamenting the death of a hero. As with much else in the Homeric epics, these scenes have a formulaic character; when Briseis laments Patroclus, and Hecuba, Andromache and Helen lament Hector, each is depicted delivering a specialized form of speech, specific to the context of a woman's lament. The narrative depiction of grieving women, as well, is formalized, with specific gestures and recurring images that typify these scenes. One element of this depiction that has largely escaped serious consideration is the comparison of a woman in her initial moment of recognition of the corpse to Aphrodite. In this article, I will argue that the allusion is not merely to her beauty but to the myth of Aphrodite and Adonis, specifically the moment of the goddess’ discovery of the death of her mortal lover. As the earliest surviving explicit reference to Adonis in Greek literature appearsc.600b.c.e., this would require a raising of theterminus ante quemfor the transmission of the Adonis myth from the Near East to the mid eighth century.
Hollywood Film behind the Iron Curtain: Cold War Nostalgias inChuck Norris vs Communism(2015)
Authors: GODEANU-KENWORTHY OANA
Published: January 2021

This article focusses on the American reception of a British–Romanian documentary about the black market for VHS Hollywood films in 1980s Romania. The film uses two different registers of nostalgia. On the one hand, it functions as an ostalgic media product that engages Eastern European viewers by building upon a sense of continuity with the socialist past. On the other hand, its surprising success in the American conservative blogosphere reveals the endurance of Cold War exceptionalist tropes. My analysis expands current discussions of post-socialist nostalgia, arguing for the relevance of the concept of ostalgia for the field of American studies.
DAVID HUME AS A PROTO-WEBERIAN: COMMERCE, PROTESTANTISM, AND SECULAR CULTURE
Authors: Schabas Margaret
Published: January 2021

David Hume wrote prolifically and influentially on economics and was an enthusiast for the modern commercial era of manufacturing and global trade. As a vocal critic of the Church, and possibly a nonbeliever, Hume positioned commerce at the vanguard of secularism. I here argue that Hume broached ideas that gesture toward those offered by Max Weber in his famous Protestant Ethic and the Spirit of Capitalism (1904-5). Hume discerned a strong correlation between economic flourishing and Protestantism, and he pointed to a “spirit of the age” that was built on modern commerce and fueled by religious tolerance. The Roman Catholic Church, by contrast, came under considerable attack by Hume, for fostering intolerance and draining and diverting funds. Hume recognized several of the dispositions that later appealed to Weber: an increased work ethic and tendency to frugality, enterprise, and investment in Protestant regions. A neo-Weberian literature now points to additional factors, the spread of literacy and the fostering of a network of trust among strangers, both of which Hume noted. Insofar as modern commerce both feeds upon and fosters more liberties and representative government, Hume also linked these with the advent and spread of Protestantism. My aim is not to suggest that these arguments have merit—there is good reason to question each and every assertion under the historical microscope—but rather to highlight the broader religious and cultural context in which Hume’s economics was broached.
Impact of population density and weather on COVID-19 pandemic and SARS-CoV-2 mutation frequency in Bangladesh
Authors: Sharif Nadim , Dey Shuvra Kanti
Published: January 2021

Coronavirus disease-2019 (COVID-19) has caused the recent pandemic worldwide. Research studies are focused on various factors affecting the pandemic to find effective vaccine or therapeutics against COVID-19. Environmental factors are the important regulators of COVID-19 pandemic. This study aims to determine the impact of weather on the COVID-19 cases, fatalities and frequency of mutations in Bangladesh. The impacts were determined on 1, 7 and 14 days of the case. The study was conducted based on Spearman's correlation coefficients. The highest correlation was found between population density and cases (rs = 0.712). Among metrological parameters, average temperature had the strongest correlation (rs = −0.675) with the cases. About 82% of Bangladeshi isolates had D614G at spike protein. Both temperature and UV index had strong effects on the frequency of mutations. Among host factors, coinfection is highly associated with frequency of different mutations. This study will give a complete picture of the effects of metrological parameters on COVID-19 cases, fatalities and mutation frequency that will help the authorities to take proper decisions.
Association between the dynamics of the COVID-19 epidemic and ABO blood type distribution
Authors: Liu Yuefei , Häussinger Lisa , Steinacker Jürgen M. , Dinse-Lambracht Alexander
Published: January 2021

The coronavirus disease 2019 (COVID-19) pandemic is currently the most critical challenge in public health. An understanding of the factors that affect severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection will help fight the COVID-19 pandemic. This study sought to investigate the association between SARS-CoV-2 infection and blood type distribution. The big data provided by the World Health Organization (WHO) and Johns Hopkins University were used to assess the dynamics of the COVID-19 epidemic. The infection data in the early phase of the pandemic from six countries in each of six geographic zones divided according to the WHO were used, representing approximately 5.4 billion people around the globe. We calculated the infection growth factor, doubling times of infection and death cases, reproductive number and infection and death cases in relation to the blood type distribution. The growth factor of infection and death cases significantly and positively correlated with the proportion of the population with blood type A and negatively correlated with the proportion of the population with blood type B. Compared with the lower blood type A population (<30%), the higher blood type A population (⩾30%) showed more infection and death cases, higher growth factors and shorter case doubling times for infections and deaths and thus higher epidemic dynamics. Thus, an association exists between SARS-CoV-2 and the ABO blood group distribution, which might be useful for fighting the COVID-19 pandemic.
Feeding outcomes after paediatric cardiothoracic surgery: a retrospective review
Authors: Hill Robert , Tey Ching S. , Jung Calvin , Monfort Robert , Pettitt-Schieber Brian , Vaughn William , Hathaway Campbell , Shashidharan Subhadra , Sharp William , Wetzel Martha , Raol Nikhila
Published: January 2021

Background:

Feeding difficulty is a known complication of congenital heart surgery. Despite this, there is a relative sparsity in the available data regarding risk factors, incidence, associated symptoms, and outcomes.

Methods:

In this retrospective chart review, patients aged 0–18 years who underwent congenital heart surgery at a single institution between January and December, 2017 were reviewed. Patients with feeding difficulties before surgery, multiple surgeries, and potentially abnormal recurrent laryngeal nerve anatomy were excluded. Data collected included patient demographics, feeding outcomes, post-operative symptoms, flexible nasolaryngoscopy findings, and rates of readmission within a 1-year follow-up period. Multivariable regression analyses were performed to evaluate the risk of an alternative feeding plan at discharge and length of stay.

Results:

Three-hundred and twenty-six patients met the inclusion criteria for this study. Seventy-two (22.09%) were discharged with a feeding tube and 70 (97.22%) of this subgroup were younger than 12 months at the time of surgery. Variables that increased the risk of being discharged with a feeding tube included patient age, The Society of Thoracic Surgeons–European Association for Cardio-Thoracic Surgery score, procedure group, aspiration, and reflux. Speech-language pathology was the most frequently utilised consulting service for patients discharged with feeding tubes (90.28%) while other services were not frequently consulted. The median length of stay was increased from 4 to 10 days for patients who required an enteral feeding tube at discharge.

Discussion:

Multidisciplinary management protocol and interventions should be developed and standardised to improve feeding outcomes following congenital heart surgery.
Midodrine treatment in children with recurrent vasovagal syncope
Authors: Bagrul Denizhan , Ece Ibrahim , Yılmaz Arzu , Atik Fatih , Kavurt Ahmet Vedat
Published: January 2021

Background:

Vasovagal syncope is the most common cause of syncope in childhood and its treatment is not at a satisfactory level yet. We aimed to investigate patients who were diagnosed with vasovagal syncope, did not benefit from conventional treatment, received midodrine treatment, and to evaluate their response to midodrine treatment.

Methods:

Files of 24 patients who were diagnosed with recurrent vasovagal syncope, did not benefit from non-pharmacological treatments, and received midodrine treatment during June 2017–October 2019 were retrospectively analysed.

Results:

In total, 24 patients received a treatment dose of midodrine at 5 mg/day (2.5 mg BID) included in the study. The mean number of syncope was 5.75 ± 2.67 prior to treatment. Following treatment, the mean number of syncope was 0.42 ± 0.89. It was observed that syncope episodes did not recur in 17 patients, but it recurred in 4 out of 7 patients in the first 3 months of the treatment and did not recur in the following months. The episodes improved in two patients with an increase in the treatment dose, but the syncope episodes continued in only one patient.

Conclusion:

It was concluded that midodrine treatment was effective and safe in adolescents with recurrent vasovagal syncope.
Junctional tachycardia due to multisystem inflammatory syndrome in children with SARS-CoV-2 infection in a 12-year-old female
Authors: Man Singh Jaikaran , Palting Rachel L. , Bratincsak Andras
Published: January 2021

A 12-year-old girl presented with fever and signs of systemic inflammation, and was found to have junctional tachycardia. She was subsequently diagnosed with Multisystem Inflammatory Syndrome in Children and treated with intravenous immunoglobulin and steroids, which led to resolution of the arrhythmia.
AN OPTIMAL LINEAR FILTER FOR ESTIMATION OF RANDOM FUNCTIONS IN HILBERT SPACE
Authors: HOWLETT PHIL , TOROKHTI ANATOLI
Published: January 2021

Let
$\boldsymbol{f}$
be a square-integrable, zero-mean, random vector with observable realizations in a Hilbert space H, and let
$\boldsymbol{g}$
be an associated square-integrable, zero-mean, random vector with realizations which are not observable in a Hilbert space K. We seek an optimal filter in the form of a closed linear operator X acting on the observable realizations of a proximate vector
$\boldsymbol{f}_{\epsilon } \approx \boldsymbol{f}$
that provides the best estimate
$\widehat{\boldsymbol{g}}_{\epsilon} = X \boldsymbol{f}_{\epsilon}$
of the vector
$\boldsymbol{g}$
. We assume the required covariance operators are known. The results are illustrated with a typical example.
The chronic uncertainty of American Indian property rights
Authors: Alston Eric , Crepelle Adam , Law Wilson , Murtazashvili Ilia
Published: January 2021

Property institutions should ideally provide economic actors with certainty that their local choices about investment will not be unsettled by shifting political economic equilibria. We argue that for this to occur, political autonomy, administrative and enforcement capacity, political constraints, and accessible legal institutions are each necessary. A comparison of the evolution of property rights for settlers and American Indians in the United States shows how political and legal forces shape the evolution of property institutions. American Indians, who had property institutions before Europeans arrived, could not defend their land from Europeans and later Americans due to lacking military capacity. Settlers' property rights were relatively secure because the government had sufficient autonomy and capacity to broadly define and enforce their rights, political institutions constrained the government from expropriating settlers' property, and legal institutions provided a forum for settlers to adjudicate and defend their rights in court. Native Americans, in contrast, had systematically inconsistent and often expropriative policy treatment by the government. Although tribes have technically been sovereign since the 1970s, tribal governments continue to lack sufficient political and legal autonomy and capacity to define and enforce property institutions in response to evolving local conditions.
Return to Work and Quality of Life in Disease-Free Adult Patients with Soft-Tissue and Bone Sarcoma of the Extremity
Authors: Kollár Attila , Müller Sabrina , Limacher Andreas , Briner Irene , Klenke Frank , Bernhard Jürg
Published: January 2021

Abstract. Treatment of extremital sarcoma patients may be associated with significant functional disabilities and psychosocial distress affecting return to work (RtW) and quality of life (QoL). In this exploratory study we prospectively investigated the RtW rate, explored biomedical and psychosocial predictors of RtW, and compared generic QoL with Swiss population norms. Forty people (89 %) returned to work. Full-time employment before sarcoma diagnosis, high educational level, and low tumor grade showed an increased probability of RtW. The median age was lower in patients who returned to work, and they reported less fear of progression. Generic QoL (SF-36) was reduced in almost all dimensions when compared to a normative Swiss population. Physical functioning and fear of progression have to be addressed in the rehabilitation process.
Special Collection on Open Collaboration Across Geosciences
Authors: Goldman Amy , Emani Sujata , P�rez-Angel Lina , Rodr�guez-Ramos Josu� , Stegen James , Fox Peter
Published: January 2021

Join open writing teams to collaborate on commentaries for a special collection describing approaches that embody synthesis, cross-disciplinary integration, and open science across geosciences.
A modular and controllable T cell therapy platform for acute myeloid leukemia
Authors: Benmebarek Mohamed-Reda , Cadilha Bruno L. , Herrmann Monika , Lesch Stefanie , Schmitt Saskia , Stoiber Stefan , Darwich Abbass , Augsberger Christian , Brauchle Bettina , Rohrbacher Lisa , Oner Arman , Seifert Matthias , Schwerdtfeger Melanie , Gottschlich Adrian , Rataj Felicitas , Fenn Nadja C. , Klein Christian , Subklewe Marion , Endres Stefan , Hopfner Karl-Peter , Kobold Sebastian
Published: January 2021

Targeted T cell therapy is highly effective in disease settings where tumor antigens are uniformly expressed on malignant cells and where off-tumor on-target-associated toxicity is manageable. Although acute myeloid leukemia (AML) has in principle been shown to be a T cell-sensitive disease by the graft-versus-leukemia activity of allogeneic stem cell transplantation, T cell therapy has so far failed in this setting. This is largely due to the lack of target structures both sufficiently selective and uniformly expressed on AML, causing unacceptable myeloid cell toxicity. To address this, we developed a modular and controllable MHC-unrestricted adoptive T cell therapy platform tailored to AML. This platform combines synthetic agonistic receptor (SAR) -transduced T cells with AML-targeting tandem single chain variable fragment (scFv) constructs. Construct exchange allows SAR T cells to be redirected toward alternative targets, a process enabled by the short half-life and controllability of these antibody fragments. Combining SAR-transduced T cells with the scFv constructs resulted in selective killing of CD33+ and CD123+ AML cell lines, as well as of patient-derived AML blasts. Durable responses and persistence of SAR-transduced T cells could also be demonstrated in AML xenograft models. Together these results warrant further translation of this novel platform for AML treatment.
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders
Authors: Delhaye Sébastien , Bardoni Barbara
Published: January 2021

Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and cGMP. They are members of a family of proteins that includes 11 subfamilies with different substrate specificities. Their main function is to catalyze the hydrolysis of cAMP, cGMP, or both. cAMP and cGMP are two key second messengers that modulate a wide array of intracellular processes and neurobehavioral functions, including memory and cognition. Even if these enzymes are present in all tissues, we focused on those PDEs that are expressed in the brain. We took into consideration genetic variants in patients affected by neurodevelopmental disorders, phenotypes of animal models, and pharmacological effects of PDE inhibitors, a class of drugs in rapid evolution and increasing application to brain disorders. Collectively, these data indicate the potential of PDE modulators to treat neurodevelopmental diseases characterized by learning and memory impairment, alteration of behaviors associated with depression, and deficits in social interaction. Indeed, clinical trials are in progress to treat patients with Alzheimer’s disease, schizophrenia, depression, and autism spectrum disorders. Among the most recent results, the application of some PDE inhibitors (PDE2A, PDE3, PDE4/4D, and PDE10A) to treat neurodevelopmental diseases, including autism spectrum disorders and intellectual disability, is a significant advance, since no specific therapies are available for these disorders that have a large prevalence. In addition, to highlight the role of several PDEs in normal and pathological neurodevelopment, we focused here on the deregulation of cAMP and/or cGMP in Down Syndrome, Fragile X Syndrome, Rett Syndrome, and intellectual disability associated with the CC2D1A gene.
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities
Authors: Schmidt Marlene F. , Gan Zhong Yan , Komander David , Dewson Grant
Published: January 2021

Neurodegenerative diseases are characterised by progressive damage to the nervous system including the selective loss of vulnerable populations of neurons leading to motor symptoms and cognitive decline. Despite millions of people being affected worldwide, there are still no drugs that block the neurodegenerative process to stop or slow disease progression. Neuronal death in these diseases is often linked to the misfolded proteins that aggregate within the brain (proteinopathies) as a result of disease-related gene mutations or abnormal protein homoeostasis. There are two major degradation pathways to rid a cell of unwanted or misfolded proteins to prevent their accumulation and to maintain the health of a cell: the ubiquitin–proteasome system and the autophagy–lysosomal pathway. Both of these degradative pathways depend on the modification of targets with ubiquitin. Aging is the primary risk factor of most neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. With aging there is a general reduction in proteasomal degradation and autophagy, and a consequent increase of potentially neurotoxic protein aggregates of β-amyloid, tau, α-synuclein, SOD1 and TDP-43. An often over-looked yet major component of these aggregates is ubiquitin, implicating these protein aggregates as either an adaptive response to toxic misfolded proteins or as evidence of dysregulated ubiquitin-mediated degradation driving toxic aggregation. In addition, non-degradative ubiquitin signalling is critical for homoeostatic mechanisms fundamental for neuronal function and survival, including mitochondrial homoeostasis, receptor trafficking and DNA damage responses, whilst also playing a role in inflammatory processes. This review will discuss the current understanding of the role of ubiquitin-dependent processes in the progressive loss of neurons and the emergence of ubiquitin signalling as a target for the development of much needed new drugs to treat neurodegenerative disease.
Glucose metabolism characteristics and TLR8-mediated metabolic control of CD4+ Treg cells in ovarian cancer cells microenvironment
Authors: Xu Rui , Wu Ming , Liu Shuna , Shang Wenwen , Li Rong , Xu Juan , Huang Lei , Wang Fang
Published: January 2021

Immunotherapy is expected to become the most promising new treatment for ovarian cancer owing to its immunogenicity. However, immunosuppression in the tumor microenvironment is a major obstacle to the efficacy of tumor therapy. Studies have found different metabolism ways of regulatory T cells (Tregs) in the cancer environment may be related to the immunosuppression and Toll-like receptor 8 (TLR8) can reverse the suppression function of Tregs. But it is still unclear that if the TLR8-mediated function reversal is associated with the change of glucose metabolism of Tregs. It was found that the positive expression rates of Glut1, HIF-1α, and Ki67 in CD4+ Treg cells of OC were significantly higher than that in benign ovarian tumor and HC, and also significantly higher than that in CD4+ Teffs of OC. What’s more, compared with CD4+ Teff group, CD4+ Tregs highly expressed seven genes and three proteins related to glucose metabolism and had higher levels of glucose uptake and glycolysis. After activating TLR8 signal of CD4+ Tregs, the proliferation level of naive CD4+ T cells was higher than that of the control group. At the same time, the expression levels of eight genes and five proteins related to glucose metabolism in CD4+ Treg cells with TLR8 activated were decreased and levels of glucose uptake and glycolysis were also lower. Furthermore, TLR8 signaling also downregulated the mTOR pathway in CD4+ Tregs. CD4+ Tregs pretreated with 2-deoxy-d-Glucose (2-DG) and galloflavin also attenuated the inhibition of Teffs proliferation. Although CD4+ Tregs pretreated with 2-DG and galloflavin before activating TLR8 signal had no significant difference compared with the group only treated with inhibitors, which suggested TLR8-mediated reversal of CD4+ Treg cells inhibitory function in ovarian cancer cells co-cultured microenvironment had a causal relationship with glucose metabolism.
Roles of HDAC3-orchestrated circadian clock gene oscillations in diabetic rats following myocardial ischaemia/reperfusion injury
Authors: Qiu Zhen , Ming Hao , Lei Shaoqing , Zhou Bin , Zhao Bo , Yu Yanli , Xue Rui , Xia Zhongyuan
Published: January 2021

The circadian clock is closely related to the development of diabetes mellitus and cardiovascular disease, and disruption of the circadian clock exacerbates myocardial ischaemia/reperfusion injury (MI/RI). HDAC3 is a key component of the circadian negative feedback loop that controls the expression pattern of the circadian nuclear receptor Rev-erbα to maintain the stability of circadian genes such as BMAL1. However, the mechanism by which the HDAC3-orchestrated Rev-erbα/BMAL1 pathway increases MI/RI in diabetes and its relationship with mitophagy have yet to be elucidated. Here, we observed that the clock genes Rev-erbα, BMAL1, and C/EBPβ oscillations were altered in the hearts of rats with streptozotocin (STZ)-induced diabetes, with upregulated HDAC3 expression. Oscillations of Rev-erbα and BMAL1 were rapidly attenuated in diabetic MI/R hearts versus non-diabetic I/RI hearts, in accordance with impaired and rhythm-disordered circadian-dependent mitophagy that increased injury. Genetic knockdown of HDAC3 significantly attenuated diabetic MI/RI by mediating the Rev-erbα/BMAL1 circadian pathway to recover mitophagy. Primary cardiomyocytes with or without HDAC3 siRNA and Rev-erbα siRNA were exposed to hypoxia/reoxygenation (H/R) in vitro. The expression of HDAC3 and Rev-erbα in cardiomyocytes was increased under high-glucose conditions compared with low-glucose conditions, with decreased BMAL1 expression and mitophagy levels. After H/R stimulation, high glucose aggravated H/R injury, with upregulated HDAC3 and Rev-erbα expression and decreased BMAL1 and mitophagy levels. HDAC3 and Rev-erbα siRNA can alleviate high glucose-induced and H/R-induced injury by upregulating BMAL1 to increase mitophagy. Collectively, these findings suggest that disruption of HDAC3-mediated circadian gene expression oscillations induces mitophagy dysfunction, aggravating diabetic MI/RI. Cardiac-specific HDAC3 knockdown could alleviate diabetic MI/RI by regulating the Rev-erbα/BMAL1 pathway to restore the activation of mitophagy.
ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis
Authors: Deng Xiaofeng , He Yu , Miao Xiongying , Yu Bo
Published: January 2021

Acute pancreatitis (AP), an acute inflammatory process, can be difficult to diagnose. Activating transcription factor 4 (ATF4) has been reported to participate in the pathogenesis of AP. Additionally, histone deacetylases (HDACs) are shown to be closely related to the development of a variety of diseases, including inflammation disease. In our study, we tried to highlight the role of ATF4 in AP through regulation of HDAC1. Firstly, we validated the effect of ATF4 on pancreatic acinar cell proliferation, apoptosis, and inflammation through in vitro experiments on cellular models of caerulein-induced AP. Next, we examined the correlation between ATF4 and HDAC1, and between HDAC1 with neutral endopeptidase (NEP) and kruppel-like factor 4 (KLF4). Finally, the regulatory role of ATF4 in AP was further assessed by determination of pathological conditions, biochemical indicators and inflammation through in vivo experiments on caerulein-induced AP mouse models. After AP induction, highly expressed ATF4 was observed, and silencing ATF4 could promote pancreatic acinar cell proliferation and inhibit apoptosis. ATF4 could bind to the HDAC1 promoter and upregulate its expression in AP. Moreover, HDAC1 could increase KLF4 expression by inhibiting NEP expression. Functionally, silencing ATF4 could suppress AP through regulation of NEP-mediated KLF4 via downregulation of HDAC1. Above all, our study uncovered the promotive role of ATF4 in AP through upregulation of HDAC1.
Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1/Cofilin-1 signaling
Authors: Wang Jie , He Zhiwei , Xu Jian , Chen Peng , Jiang Jianxin
Published: January 2021

An accumulation of evidence indicates that long noncoding RNAs are involved in the tumorigenesis and progression of pancreatic cancer (PC). In this study, we investigated the functions and molecular mechanism of action of LINC00941 in PC. Quantitative PCR was used to examine the expression of LINC00941 and miR-335-5p in PC tissues and cell lines, and to investigate the correlation between LINC00941 expression and clinicopathological features. Plasmid vectors or lentiviruses were used to manipulate the expression of LINC00941, miR-335-5p, and ROCK1 in PC cell lines. Gain or loss-of-function assays and mechanistic assays were employed to verify the roles of LINC00941, miR-335-5p, and ROCK1 in PC cell growth and metastasis, both in vivo and in vitro. LINC00941 and ROCK1 were found to be highly expressed in PC, while miR-335-5p exhibited low expression. High LINC00941 expression was strongly associated with larger tumor size, lymph node metastasis, and poor prognosis. Functional experiments revealed that LINC00941 silencing significantly suppressed PC cell growth, metastasis and epithelial–mesenchymal transition. LINC00941 functioned as a molecular sponge for miR-335-5p, and a competitive endogenous RNA (ceRNA) for ROCK1, promoting ROCK1 upregulation, and LIMK1/Cofilin-1 pathway activation. Our observations lead us to conclude that LINC00941 functions as an oncogene in PC progression, behaving as a ceRNA for miR-335-5p binding. LINC00941 may therefore have potential utility as a diagnostic and treatment target in this disease.
Snai1-induced partial epithelial–mesenchymal transition orchestrates p53–p21-mediated G2/M arrest in the progression of renal fibrosis via NF-κB-mediated inflammation
Authors: Qi Ruochen , Wang Jiyan , Jiang Yamei , Qiu Yue , Xu Ming , Rong Ruiming , Zhu Tongyu
Published: January 2021

Renal fibrosis is the common feature of all progressive kidney diseases and exerts great burden on public health worldwide. The maladaptive repair mechanism of tubular epithelial cells, an important mediator of renal fibrogenesis, manifests with partial epithelial–mesenchymal transition (EMT) and cell cycle arrest. The aim of this study is to investigate the possible correlation between partial EMT and cell cycle arrest, and elucidate the underlying mechanism. We examined human kidney allograft samples with interstitial fibrosis and three mice renal fibrosis models, unilateral ureter obstruction (UUO), ischemia–reperfusion injury, and Adriamycin nephropathy. The partial EMT process and p53–p21 axis were elevated in both human allograft with interstitial fibrosis, as well as three mice renal fibrosis models, and showed a time-dependent increase as fibrosis progressed in the UUO model. Snai1 controlled the partial EMT process, and led to parallel changes in renal fibrosis, G2/M arrest, and inflammation. p53–p21 axis arrested cell cycle at G2/M, and prompted partial EMT and fibrosis together with inflammation. NF-κB inhibitor Bay11-7082 disrupted the reciprocal loop between Snai1-induced partial EMT and p53–p21-mediated G2/M arrest. We demonstrated the reciprocal loop between partial EMT and G2/M arrest of TECs during renal fibrogenesis and revealed NF-κB-mediated inflammatory response as the underlying mechanism. This study suggests that targeting NF-κB might be a plausible therapeutic strategy to disrupt the reciprocal loop between partial EMT and G2/M arrest, therefore alleviating renal fibrosis.
Gridded fossil CO2 emissions and related O2 combustion consistent with national inventories 1959–2018
Authors: Jones Matthew W. , Andrew Robbie M. , Peters Glen P. , Janssens-Maenhout Greet , De-Gol Anthony J. , Ciais Philippe , Patra Prabir K. , Chevallier Frederic , Le Quéré Corinne
Published: January 2021

Quantification of CO2 fluxes at the Earth’s surface is required to evaluate the causes and drivers of observed increases in atmospheric CO2 concentrations. Atmospheric inversion models disaggregate observed variations in atmospheric CO2 concentration to variability in CO2 emissions and sinks. They require prior constraints fossil CO2 emissions. Here we describe GCP-GridFED (version 2019.1), a gridded fossil emissions dataset that is consistent with the national CO2 emissions reported by the Global Carbon Project (GCP). GCP-GridFEDv2019.1 provides monthly fossil CO2 emissions estimates for the period 1959–2018 at a spatial resolution of 0.1°. Estimates are provided separately for oil, coal and natural gas, for mixed international bunker fuels, and for the calcination of limestone during cement production. GCP-GridFED also includes gridded estimates of O2 uptake based on oxidative ratios for oil, coal and natural gas. It will be updated annually and made available for atmospheric inversions contributing to GCP global carbon budget assessments, thus aligning the prior constraints on top-down fossil CO2 emissions with the bottom-up estimates compiled by the GCP.
Polypyridyl Co complex-based water reduction catalysts: why replace a pyridine group with isoquinoline rather than quinoline?
Authors: Guo Xusheng , Li Chao , Wang Weibo , Hou Yuanjun , Zhang Baowen , Wang Xuesong , Zhou Qianxiong
Published: January 2021

The replacement of a pyridine group of [Co(TPA)Cl]+ by a quinoline or an isoquinoline group was observed to have an opposite effect on H2 evolution.
Fucosyltransferase-specific inhibition via next generation of fucose mimetics
Authors: Martin Kyle C. , Tricomi Jacopo , Corzana Francisco , García-García Ana , Ceballos-Laita Laura , Hicks Thomas , Monaco Serena , Angulo Jesus , Hurtado-Guerrero Ramon , Richichi Barbara , Sackstein Robert
Published: January 2021

A conformationally constrained mimetic of l-fucose has been employed to explore whether glycan mimicry could be utilized to interfere with the catalytic activity of α-1,3-fucosyltransferases.
Manganese-catalyzed selective C–H activation and deuteration by means of a catalytic transient directing group strategy
Authors: Kopf Sara , Neumann Helfried , Beller Matthias
Published: January 2021

A shortcut to ortho-deuterated aldehydes: a catalytic directing group enables the manganese-catalyzed C–H activation and deuteration of benzaldehydes in one step.
Electrochemical characterization and thermodynamic analysis of TEMPO derivatives in ionic liquids
Authors: Wylie Luke , Hakatayama-Sato Kan , Go Choitsu , Oyaizu Kenichi , Izgorodina Ekaterina I.
Published: January 2021

In this study we tailor the reversibility of the reduction process of three TEMPO derivatives – TEMPOL, 4-cyano-TEMPO, and 4-oxo-TEMPO – using ionic liquids.
Bulk supercooled water versus adsorbed films on silica surfaces: specific heat by Monte Carlo simulation
Authors: Puibasset J. , Judeinstein P. , Zanotti J.-M.
Published: January 2021

Does interfacial supercooled water exhibit heat capacity maximum at 225 K?
Advent of alkali metal doping: a roadmap for the evolution of perovskite solar cells
Authors: Kausar Ammarah , Sattar Abdul , Xu Chenzhe , Zhang Suicai , Kang Zhuo , Zhang Yue
Published: January 2021

Metal–halide hybrid perovskites have prompted the prosperity of the sustainable energy field and simultaneously demonstrated their great potential in meeting both the growing consumption of energy and the increasing social development requirements.
Economically detaching transparent and flexible (Al,Ga)N nanowire films with improved photoelectric response in view of ultraviolet photodetectors
Authors: Xing Zhiwei , Zhao Yukun , Bian Lifeng , Zhang Jianya , Zhou Min , Yang Wenxian , Wu Yuanyuan , Jiang Min , Long Junhua , Lu Shulong
Published: January 2021

The (Al,Ga)N nanowire film with good flexibility and transparency has been achieved by a electrochemical procedure with low cost. Detaching such films can enhance the peak responsivity and decrease the decay time of ultraviolet photodetectors.
Nanoconfined growth of lithium-peroxide inside electrode pores: a noncatalytic strategy toward mitigating capacity–rechargeability trade-off in lithium–air batteries
Authors: Dutta Arghya , Ito Kimihiko , Kubo Yoshimi
Published: January 2021

Controlled modification of a mesoporous carbon electrode mitigates the capacity–rechargeability trade-off in Li–air batteries by pore-confined growth of nanocrystalline Li2O2.
Journal of Materials Chemistry A and Materials Advances Editor's choice web collection: “Recent advances in hydrothermal materials synthesis”
Authors: Unterlass Miriam M.
Published: January 2021

Miriam M. Unterlass introduces a Journal of Materials Chemistry/Materials Advances Editor's choice web collection on recent advances in hydrothermal materials synthesis (https://rsc.li/hydrothermal).
Novel dual acceptor (D–D′–A′–π–A) dye-sensitized solar cells based on the triarylamine structure and benzothiadiazole double electron withdrawing unit
Authors: Zheng Peijin , Xu Jian , Peng Fei , Peng Shengming , Liao Junxu , Zhao Hongbin , Li Ledong , Zeng Xiangyan , Yu Heyu
Published: January 2021

Three D–D′–A′–π–A dyes BT4–6 using triarylamine derivatives with varied D′ units as donors were synthesized. The result suggests that the difference of D′ units have significant effects on their physicochemical property and photovoltaic performance.
Microbial engineering for the production of C2–C6organic acids
Authors: Li Yang , Yang Shujie , Ma Danlei , Song Wei , Gao Cong , Liu Liming , Chen Xiulai
Published: January 2021

Organic acids have broad applications in food, pharmaceutical, and chemical industries. Currently, many metabolic engineering strategies have been used to engineer microorganisms for producing value-added chemicals from various renewable feedstocks.
Recent advances in single-benzene-based fluorophores: physicochemical properties and applications
Authors: Kim Jaehoon , Oh Ji Hyeon , Kim Dokyoung
Published: January 2021

The recently reported physicochemical properties and applications of single-benzene-based fluorophores (SBBFs) are summarized.
Pd(ii)-Based polyoxometalate polymers as highly efficient heterogeneous catalysts for Suzuki–Miyaura reactions
Authors: Hou Jiayou , Zhang Lin , Li Yunjing , Xia Yan , Huang Zixuan , Fu Hai , Guo Peipei , Ao Yuhui
Published: January 2021

Five Pd(ii)/polyoxometalate catalysts with a unique atomic arrangement and high Pd loading were synthesized under solvothermal conditions, and their structures were determined by single crystal X-ray diffraction.
Aza-BODIPY encapsulated polymeric nanoparticles as an effective nanodelivery system for photodynamic cancer treatment
Authors: Treekoon Jongjit , Chansaenpak Kantapat , Tumcharern Gamolwan , Zaiman Zain Zurain Syahira , Lee Hong Boon , Kue Chin Siang , Kamkaew Anyanee
Published: January 2021

Novel aza-BODIPY based polymeric nanoparticles were created using simple nanoprecipitation method. The prepared materials can be efficiently applied for breast cancer cell treatment upon NIR light irradiation in cellular and murine model.
Ethyl cyanoacrylate reinforced polyvinylidene fluoride separators for robust lithium ion batteries
Authors: Yang Mengqiu , Liu Yuanpeng , Yuan Botao , Guang Zhaoxu , Liu Jipeng , Dong Liwei , Ji Yuanpeng , Li Qun , Liang Yifang , Dong Yunfa , Hao Sue , Yang Chunhui , He Weidong
Published: January 2021

Herein a composite separator is proposed to realize high mechanical strength, high thermal stability and high electrolyte wettability by incorporating ethyl cyanoacrylate (ECA) into polyvinylidene fluoride (PVDF).
Recent advances in hydride transfer-involved C(sp3)–H activation reactions
Authors: An Xiao-De , Xiao Jian
Published: January 2021

This review summarizes the recent progresses (2016–2020) in the hydride transfer-enabled C(sp3)–H activation according to the reaction types, categorized into the intramolecular/intermolecular C(sp3)–H functionalization, and hydride reduction.
Liquid marble clearance and restorationviagas bubble insertion and bursting
Authors: Lin Eric Shen , Song Zhixiong , Ong Jian Wern , Abid Hassan Ali , Chung Kim Chung Dwayne , Huynh So Hung , Liew Oi Wah , Ng Tuck Wah
Published: January 2021

The introduction of a gas bubble is a simple way to disrupt the apical coating of particles on liquid marbles to introduce additional reagents.
Elastic strain controlling the activity and selectivity of CO2 electroreduction on Cu overlayers
Authors: Du Minshu , Zhao Xin , Zhu Geju , Hsu Hsien-Yi , Liu Feng
Published: January 2021

Elastic strain effects on Cu overlayers toward CO2 electroreduction reaction were studied.
High efficiency nitrogen doping and single atom cobalt anchoringviasupermolecules for oxygen reduction electrocatalysis
Authors: Chen Yuanyuan , Li Xiujuan , Liao Weijie , Qiu Lei , Yang Haitao , Yao Lei , Deng Libo
Published: January 2021

High nitrogen doping efficiency and atomic dispersion of CoN4sites in carbon are achieved by pyrolysis of cyclodextrin-based supermolecules, which exhibits impressive electrocatalytic activity during oxygen reduction reaction.
How oxidation state and lattice distortion influence the oxygen evolution activity in acid of iridium double perovskites
Authors: Retuerto María , Pascual Laura , Piqué Oriol , Kayser Paula , Salam Mohamed Abdel , Mokhtar Mohamed , Alonso José Antonio , Peña Miguel , Calle-Vallejo Federico , Rojas Sergio
Published: January 2021

In view of iridium's scarceness and high cost, Ir-containing catalysts for water electrolyzers should have low loadings and maximal utilization.
Single-atom oxygen reduction reaction electrocatalysts of Fe, Si, and N co-doped carbon with 3D interconnected mesoporosity
Authors: Kim Hee Soo , Lee Chi Ho , Jang Jue-Hyuk , Kang Min Seok , Jin Haneul , Lee Kug-Seung , Lee Sang Uck , Yoo Sung Jong , Yoo Won Cheol
Published: January 2021

ORR activity of Fe, Si, and N co-doped carbons (FeSiNCs) is first reported that DFT calculations reveal the origin of the ORR activity of FeSiNC, presenting excellent ORR activity and single-cell performances in Zn–air battery and AEMFC.
An in-depth insight of a highly reversible and dendrite-free Zn metal anode in an hybrid electrolyte
Authors: Zhang Yuanjun , Zhu Ming , Wu Kuan , Yu Fangfang , Wang Guanyao , Xu Gang , Wu Minghong , Liu Hua-Kun , Dou Shi-Xue , Wu Chao
Published: January 2021

The composition of inactive Zn responsible for the capacity loss is identified and quantified. Based on this result, an environmentally friendly glycerol/water hybrid electrolyte is developed to promote the uniform deposition of the Zn metal.
Mesoporous Rh nanotubes for efficient electro-oxidation of methanol
Authors: Wang Shengqi , Liu Songliang , Wang Ziqiang , Dai Zechuan , Yu Hongjie , Xu You , Li Xiaonian , Wang Liang , Wang Hongjing
Published: January 2021

We report a simple dual-template strategy for in situ fabrication of one-dimensional rhodium mesoporous nanotubes towards methanol oxidation.
Promoting sulphur conversion chemistry with tri-modal porous N, O-codoped carbon for stable Li–S batteries
Authors: Wu Dapeng , Liu Jiayi , Chen Junliang , Li Huanhuan , Cao Ruiguo , Zhang Wenchao , Gao Zhiyong , Jiang Kai
Published: January 2021

A tri-modal hierarchical porous carbon framework with N, O dual heteroatom doping is designed and prepared. The synergy between optimized pore size distribution and efficient surface-chemistry confinement of sulfur resulted in quick redox kinetics of lithium polysulfides.
Electronic and crystal structure of bi-intercalated titanium diselenide CuxNiyTiSe2
Authors: Shkvarina E. G. , Merentsov A. I. , Postnikov M. S. , Shkvarin A. S. , Pryanichnikov S. V. , Píš I. , Nappini S. , Bondino F. , Titov A. N.
Published: January 2021

A comprehensive study of the crystal and electronic structure of TiSe2 intercalated with two 3d metals, Cu and Ni, is presented.
Quantitative chiral sensing of organic acids by benzimidazole derivatives through H-bond coassembly
Authors: Zhao Jianjian , Hao Aiyou , Xing Pengyao
Published: January 2021

A H-bonded binary coassembly by benzimidazole derivatives enables highly accurate ee% detection of hydrophilic chiral acids.
Galaxy and Mass Assembly: Group and field galaxy morphologies in the star-formation rate – stellar mass plane
Authors: Pearson W. J. , Wang L. , Brough S. , Holwerda B. W. , Hopkins A. M. , Loveday J.
Published: January 2021

Aims. We study the environment in which a galaxy lies (i.e. field or group) and its connection with the morphology of the galaxy. This is done by examining the distribution of parametric and non-parametric statistics across the star-formation rate (SFR) – stellar mass (M⋆) plane and studying how these distributions change with the environment in the local universe (z < 0.15).

Methods. We determine the concentration (C), Gini, M20, asymmetry, Gini-M20 bulge statistic (GMB), 50% light radius (r50), total Sérsic index, and bulge Sérsic index (nBulge) for galaxies from the Galaxy and Mass Assembly (GAMA) survey using optical images from the Kilo Degree Survey. We determine the galaxy environment using the GAMA group catalogue and split the galaxies into field or group galaxies. The group galaxies are further divided by the group halo mass (Mh)−11 ≤ log(Mh/M⊙) < 12, 12 ≤ log(Mh/M⊙) < 13, and 13 ≤ log(Mh/M⊙) < 14 – and into central and satellite galaxies. The galaxies in each of these samples are then placed onto the SFR-M⋆ plane, and each parameter is used as a third dimension. We fit the resulting distributions for each parameter in each sample using two two-dimensional Gaussian distributions: one for star-forming galaxies and one for quiescent galaxies. The coefficients of these Gaussian fits are then compared between environments.

Results. Using C and r50, we find that galaxies typically become larger as the group mass increases. This change is greater for larger galaxies. There is no indication that galaxies are typically more or less clumpy as the environment changes. Using GMB and nBulge, we see that the star-forming galaxies do not become more bulge or disk dominated as the group mass changes. Asymmetry does not appear to be greatly influenced by environment.
Dossier « L’économie circulaire : modes de gouvernance et développement territorial » – « La méthanisation, oui, mais pas chez moi ! » Une analyse du discours des acteurs dans la presse quotidienne régionale
Authors: Bourdin Sébastien , Jeanne Philippe , Raulin François
Published: January 2021

La transition énergétique est aujourd’hui considérée par les institutions nationales, européennes et internationales comme incontournable. Cependant, le déploiement des énergies renouvelables telles que la méthanisation peut être source de conflit. À partir d’un corpus d’articles issus de la presse quotidienne régionale, nous avons réalisé une analyse lexicométrique du discours des acteurs de la méthanisation afin de mieux comprendre les oppositions locales et d’identifier les leviers pour faciliter l’acceptation sociale. L’étude analyse les craintes et les principales méfiances liées à la méthanisation. Par conséquent, la territorialisation des projets d’unités de méthanisation nécessite de trouver de nouveaux compromis sociaux en conciliant l’intérêt général (la transition énergétique) et les intérêts singuliers (relatifs aux externalités des énergies vertes déployées).
The Complexity of Relationships within Business and the Importance of Common Ground
Authors: Ābeltiņa Anna , Rizhamadze Ketevan
Published: January 2021

In today’s rapidly evolving digital and social media dominated world, traditional marketing approaches are becoming obsolete. Companies are trying to alter the workplace into a vibrant one that enhances the talent of the people and to manage complex relationships inside and outside the organization. The following paper illustrates the complexity of relationships that companies have to handle. It is argued that the embeddedness of relationships plays a crucial role, notably in the business-to-business (B2B) relationship and that finding common ground is pivotal. The nature of the research methodology adopted for this study is primarily quantitative. All analyses are based on secondary data obtained through books, articles, and publications. The findings of the research indicate that the B2B relationship is a complex and multi-layered subject. Furthermore, for conflict resolution, taking into consideration the cultural differences in the decision-making process is fundamental. The presented study is exploratory in nature and therefore cannot be generalized for the general public. The findings are important for managers and entrepreneurs who need to be aware of the complexity of the business-to-business context. Although the nature of the study is exploratory, the study is original because it highlights some vital aspects upon which managers can reflect and dwell on.