bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Corticosteroid Injections on Postoperative Infections in Trigger Finger Release
Authors: Kirby David , Donnelly Megan , Catalano Will , Buchalter Daniel , Glickel Steven , Hacquebord Jacques
Published: July 2021

Background

Corticosteroid injections have proven benefit in the treatment of symptomatic trigger finger; however, the immune system and tissue repair modulating properties of corticosteroids justify further consideration in surgical candidates. The aim of this study was to assess the relationship between corticosteroid injections and postoperative infection in trigger finger release.

Methods

A single-center retrospective review was conducted of patients seen from 2010 to 2019 to identify those who underwent trigger finger release with subsequent antibiotic prescription for chart-documented wound infection. A demographic matched cohort of 100 patients was identified for comparison. Preoperative corticosteroid injection history including timing, frequency, and dose was collected for all patients. Patient demographics, comorbidities, and presence of postoperative infection were collected from patient medical records. Superficial infection was defined as those requiring antibiotics for resolution without return to the operating room; deep infection was defined as infections that required irrigation and debridement.

Results

Of 3234 patients who underwent trigger finger release, 58 (1.8%) were identified with postoperative infections, 6 (0.2%) of which were deep infections. History of corticosteroid injection was significantly more common in patients with postoperative infection. Compared with an age-matched, gender-matched, and body mass index–matched cohort, patients with postoperative infection had significantly increased rate of diabetes mellitus at 34.5% to 19% ( P = .04)

Conclusions

While corticosteroid injection in the preoperative period is associated with a higher rate of postoperative infection, the time before surgery and the corticosteroid dose do not appear to have an effect.
Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model
Authors: Hede Kris T. C. , Christensen Bjørn B. , Olesen Morten L. , Thomsen Jesper Skovhus , Foldager Casper B. , Toh Wei Seong , Lim Sai Kiang , Lind Martin C.
Published: July 2021

Objective

This study evaluated the effects of mesenchymal stem cell-extracellular vesicles (MSC-EVs) on chondrocyte proliferation in vitro and on cartilage repair in vivo following bone marrow stimulation (BMS) of focal chondral defects of the knee.

Methods

Six adult Göttingen minipigs received 2 chondral defects in each knee. The pigs were randomized to treatment with either BMS combined with MSC-EVs or BMS combined with phosphate-buffered saline (PBS). Intraarticular injections MSC-EVs or PBS were performed immediately after closure of the surgical incisions, and at 2 and 4 weeks postoperatively. Repair was evaluated after 6 months with gross examination, histology, histomorphometry, immunohistochemistry, and micro-computed tomography (µCT) analysis of the trabecular bone beneath the defect.

Results

Defects treated with MSC-EVs had more bone in the cartilage defect area than the PBS-treated defects (7.9% vs. 1.5%, P = 0.02). Less than 1% of the repair tissue in both groups was hyaline cartilage. International Cartilage and Joint Preservation Society II histological scoring showed that defects treated with MSC-EVs scored lower on “matrix staining” (20.8 vs. 50.0, P = 0.03), “cell morphology” (35.4 vs. 53.8, P = 0.04), and “overall assessment” (30.8 vs. 52.9, P = 0.03). Consistently, defects treated with MSC-EVs had lower collagen II and higher collagen I areal deposition. Defects treated with MSC-EVs had subchondral bone with significantly higher tissue mineral densities than PBS-treated defects (860 mg HA/cm3 vs. 838 mg HA/cm3, P = 0.02).

Conclusion

Intraarticular injections of MSC-EVs in conjunction with BMS led to osseous ingrowth that impaired optimal cartilage repair, while enhancing subchondral bone healing.
Improving Communications With Patients and Families in Geriatric Care. The How, When, and What
Authors: Huang Shirley Chien-Chieh , Morgan Alden , Peck Vanessa , Khoury Lara
Published: July 2021

There has been little published literature examining the unique communication challenges older adults pose for health care providers. Using an explanatory mixed-methods design, this study explored patients’ and their family/caregivers’ experiences communicating with health care providers on a Canadian tertiary care, inpatient Geriatric unit between March and September 2018. In part 1, the modified patient–health care provider communication scale was used and responses scored using a 5-point scale. In part 2, one-on-one telephone interviews were conducted and responses transcribed, coded, and thematically analyzed. Thirteen patients and 7 family/caregivers completed part 1. Both groups scored items pertaining to adequacy of information sharing and involvement in decision-making in the lowest 25th percentile. Two patients and 4 family/caregivers participated in telephone interviews in part 2. Interview transcript analysis resulted in key themes that fit into the “How, When, and What” framework outlining the aspects of communication most important to the participants. Patients and family/caregivers identified strategic use of written information and predischarge family meetings as potentially valuable tools to improve communication and shared decision-making.
A qualitative study about the mental health and wellbeing of older adults in the UK during the COVID-19 pandemic
Authors: McKinlay A. R. , Fancourt D. , Burton A.
Published: July 2021

Objectives

The objective of this study was to examine factors that threatened and protected the wellbeing of older adults living in the UK during social distancing restrictions due to the COVID-19 pandemic.

Methods

Semi-structured telephone or video interviews with 20 adults aged over 70. Purposive sampling methods were used to increase diversity within the group. Transcripts were analysed using reflexive thematic analysis.

Results

Participants described potential threats to their wellbeing during the pandemic, including fears for mortality, grieving normal life, and concerns for the future. Participants also described activities and behaviours that helped to protect their mental health, including adopting a slower pace of life, maintaining routine, socialising, and using past coping skills. Many participants drew on their resilience and life experience to self-manage fear and uncertainty associated with the pandemic, using their time during lockdown to reflect or organise end-of-life affairs.

Discussion

This study provides UK-based evidence that while some older adults experienced challenges during the first wave of COVID-19, many were resilient throughout social distancing restrictions despite early reported concerns of mental health consequences among the older adult population. Our findings highlight the importance of maintaining access to essentials to promote feelings of normality and use of social support to help reduce uncertainty in times of pandemics.
Understanding factors relevant to poor sleep and coping methods in people with schizophrenia
Authors: Chang Yen-Ching , Chang Megan C. , Chang Yun-Jou , Chen Ming-De
Published: July 2021

Background

Sleep disruption is pervasive in people with schizophrenia, but few studies have explored their sleep experiences. This study aims to identify factors relevant to sleep problems and explore coping methods used by community-dwelling people with schizophrenia.

Methods

Eighteen participants with schizophrenia were recruited from three mental health centers in Taiwan. They completed a semi-structured interview and the Pittsburgh Sleep Quality Index (PSQI) assessment. The Person-Environment-Occupation model offered a framework to assess factors related to sleep. Thematic analysis was used for the qualitative data analysis.

Results

Factors related to sleep were classified under person, environment, and occupation domains. The person domain included three subthemes: psychiatric symptoms, unpleasant emotions, and frustration about sleep. The environment domain included three subthemes: sensory intrusions from the environment, quality of bedding, and roommates. The occupation domain included sleep interruption and sleep preparation. There were notable discrepancies in sleep quality between the participants’ narratives and their PSQI global scores. Regarding coping methods for poor sleep, sleep medication was the primary strategy while some participants also used other strategies, such as modifying the environment, adjusting routines, or engaging in activities that improve sleep quality.

Conclusions

Psychiatric symptoms and nightmares were identified as unique sleep disruptions in people with schizophrenia, and poor economic status was also found to impact their sleep. The sleep quality of people with schizophrenia tends to be poor, as identified by the PSQI, even though they may have positive perceptions of their sleep quality. Our participants appeared to prefer to take hypnotics to address their sleep problems, which may be due to limited knowledge about alternatives. Mental health professionals are encouraged to receive training in the application of non-pharmacological approaches to support their clients’ issues related to sleep.
The Group Nurturance Inventory — initial psychometric evaluation using Rasch and factor analysis
Authors: Johansson Magnus , Biglan Anthony
Published: July 2021

Background

This paper describes the development and psychometric evaluation of a behavioral assessment instrument primarily intended for use with workgroups in any type of organization. The instrument was developed based on the Nurturing Environments framework which describes four domains important for health, well-being, and productivity; minimizing toxic social interactions, teaching and reinforcing prosocial behaviors, limiting opportunities for problem behaviors, and promoting psychological flexibility. The instrument is freely available to use and adapt under a CC-BY license and intended as a tool that is easy for any group to use and interpret to identify key behaviors to improve their psychosocial work environment.

Methods

Questionnaire data of perceived frequency of behaviors relevant to nurturance were collected from nine different organizations in Sweden. Data were analyzed using confirmatory factor analysis, Rasch analysis, and correlations to investigate relationships with relevant workplace measures.

Results

The results indicate that the 23-item instrument is usefully divided in two factors, which can be described as risk and protective factors. Toxic social behaviors make up the risk factor, while the protective factor includes prosocial behavior, behaviors that limit problems, and psychological flexibility. Rasch analysis showed that the response categories work as intended for all items, item fit is satisfactory, and there was no significant differential item functioning across age or gender. Targeting indicates that measurement precision is skewed towards lower levels of both factors, while item thresholds are distributed over the range of participant abilities, particularly for the protective factor. A Rasch score table is available for ordinal to interval data transformation.

Conclusions

This initial analysis shows promising results, while more data is needed to investigate group-level measurement properties and validation against concrete longitudinal outcomes. We provide recommendations for how to work in practice with a group based on their assessment data, and how to optimize the measurement precision further. By using a two-dimensional assessment with ratings of both frequency and perceived importance of behaviors the instrument can help facilitate a participatory group development process. The Group Nurturance Inventory is freely available to use and adapt for both commercial and non-commercial use and could help promote transparent assessment practices in organizational and group development.
Association of depressive symptoms and risk of knee pain: the moderating effect of sex
Authors: Hu Haiyan , Liu Wenjun , Liu Yang , Pan Jay , Zheng Xiaozuo
Published: July 2021

Background

Depression has been shown in some studies to be associated with knee pain. Females were widely recognized as more vulnerable to depression and knee pain than males. However, the role of sex in this correlation was under-researched. This study aimed to investigate the association between depressive symptoms and subsequent knee pain, as well as whether and how sex would moderate this association based on a four-wave (Wave 1 in 2010–2011, Wave 2 in 2013, Wave 3 in 2015, and Wave 4 in 2018) longitudinal study among middle-aged and elderly Chinese adults.

Methods

Seventeen thousand seven hundred eight participants were recruited and followed in the China Health and Retirement Longitudinal Study (CHARLS). Ten thousand four hundred fifty-one entered the final analysis based on the inclusion and exclusion criteria. Knee pain was assessed by self-report. Depressive symptoms were evaluated using the validated 10-item Center for Epidemiological Studies-Depression Scale (CESD-10). Cox proportional hazards models were used to calculate hazard ratios with 95% confidence intervals (CIs) after controlling potential confounders to examine the association between depressive symptoms and subsequent incident and persistent knee pain. Non-linear association of depressive symptoms score (CESD-10) and risk of knee pain was also investigated via applying 3-knotted restricted cubic spline regression. An interaction term of depressive symptoms status and sex was added to investigate the moderating effect of sex on the relationship between depressive symptoms status and the risk of knee pain.

Results

The median follow-up time was seven years for all the outcomes. Participants with depressive symptoms were 1.45 times (95% CI: 1.34–1.56) and 2.16 times (95% CI: 1.85–2.52) more likely to develop the incident and persistent knee pain after multivariable were adjusted, compared with those without depressive symptoms. There was a non-linear association between CESD-10 score and risk of knee pain. Compared with females, males had an enhanced correlation between depressive symptoms status and knee pain (multivariable-adjusted HR: 1.22, 95% CI: 1.05–1.42 and HR: 1.57, 95% CI: 1.14–2.17 for the incident and persistent knee pain, respectively).

Conclusion

Depressive symptoms are independently associated with an excess risk of knee pain, with a stronger correlation for males than females among middle-aged and elderly Chinese adults.
A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs
Authors: Meurs Kathryn M. , Montgomery Keith , Friedenberg Steven G. , Williams Brian , Gilger Brian C.
Published: July 2021

Background

Superficial chronic corneal epithelial defects (SCCEDs) are spontaneous corneal defects in dogs that share many clinical and pathologic characteristics to recurrent corneal erosions (RCE) in humans. Boxer dogs are predisposed to SCCEDs, therefore a search for a genetic defect was performed to explain this susceptibility. DNA was extracted from blood collected from Boxer dogs with and without SCCEDs followed by whole genome sequencing (WGS). RNA sequencing of corneal tissue and immunostaining of corneal sections from affected SCCED Boxer dogs with a deletion in the NOG gene and affected non-Boxer dogs without the deletion were performed.

Results

A 30 base pair deletion at a splice site in Noggin (NOG) (Chr 9:31453999) was identified by WGS and was significantly associated (P < 0.0001) with Boxer SCCEDs compared to unaffected non-Boxer dogs. NOG, BMP4, MMP13, and NCAM1 all had significant fold reductions in expression and SHH was significantly increased in Boxers with the NOG deletion as identified by RNA-Seq. Corneal IHC from NOG deletion dogs with SCCEDs had lower NOG and significantly higher scores of BMP2.

Conclusions

Many Boxer dogs with SCCED have a genetic defect in NOG. NOG is a constitutive protein in the cornea which is a potent inhibitor of BMP, which likely regulate limbal epithelial progenitor cells (LEPC). Dysregulation of LEPC may play a role in the pathogenesis of RCE.
Severe stunting and its associated factors among children aged 6–59 months in Ethiopia; multilevel ordinal logistic regression model
Authors: Muche Amare , Dewau Reta
Published: July 2021

Background

In Ethiopia, stunting is the most common form of undernutriton. Identifying the determinants of severe stunting among children is crucial for public health interventions to improve child health. Therefore, this study aimed to identify the determinants of severe stunting among under-five children in Ethiopia.

Methods

A community-based cross-sectional study design was employed. A two stage stratified cluster sampling technique was used. A multilevel ordinal logistic regression model was fitted to identify independent determinants. Adjusted odds ratio (AOR) and median odds ratio (MOR) with its 95% confidence interval atp-value< 0.05 were used to declare statistical significance.

Results

The result of this study showed that about 18% of the children were severely stunted. Being male increased the severity of stunting in children by 26% adjusted odds ratio (AOR): 1.26 (95% CI: 1.09–1.46), compared to female sex; over-weight mothers increased the severity of stunting in their children AOR: 3.43 (95% CI: 2.21–5.33) compared to normal BMI mothers; and children from middle, poorer, and poorest wealth index households were 1.84 (95% CI:1.27–2.67), 2.13 (95% CI, CI:1.45–3.14) and 2.52 (95% CI,1.72–3.68). In contrast, severe stunting was reduced by 62% (AOR: 0.38, 95% CI: 0.20–0.74) and 48% (AOR = 0.52, 95% CI: 0.37–0.72) in children of educated mothers compared to children of uneducated mothers and children of underweight mothers compared with those children of normal BMI mothers respectively. For each one-unit increase in maternal height, there is a 5% significant reduction in the child’s odds of being severely stunted. After controlling for other factors, the effect of predictors on the likelihood of stunting in high risk clusters increased by a median odds ratio (MOR) of 1.83 (95% CI: 1.69–2.00).

Conclusions

The magnitude of severe childhood stunting was still high with regional variation in Ethiopia. Child age, sex, maternal height, age, education and household wealth index as well as administrative regions were significantly associated factors with severe stunting. Significant interventions shall be implemented at the individual, household and community levels in order to reduce the problem.
Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status
Authors: Babapour Mofrad Rosha , Scheltens Philip , Kim SangYun , Kang Sungmin , Youn Young Chul , An Seong Soo A. , Tomassen Jori , van Berckel Bart N. M. , Visser Pieter Jelle , van der Flier Wiesje M. , Teunissen Charlotte E.
Published: July 2021

Objective

We assessed the performance of plasma amyloid oligomerization tendency (OAβ) as a marker for abnormal amyloid status. Additionally, we examined long-term storage effects on plasma OAβ.

Methods

We included 399 subjects regardless of clinical diagnosis from the Amsterdam Dementia Cohort and European Medical Information Framework for AD project (age, 63.8 ± 6.6; 44% female). Amyloid status was determined by visual read on positron emission tomography (PET; nabnormal = 206). Plasma OAβ was measured using the multimer detection system (MDS). Long-term storage effects on MDS-OAβ were assessed using general linear models. Associations between plasma MDS-OAβ and Aβ-PET status were assessed using logistic regression and receiver operating characteristics analyses. Correlations between plasma MDS-OAβ and CSF biomarker levels were evaluated using Pearson correlation analyses.

Results

MDS-OAβ was higher in individuals with abnormal amyloid, and it identified abnormal Aβ-PET with an area under the curve (AUC) of 0.74 (95% CI, 0.67–0.81), especially in samples with a storage duration < 4 years. Combining APOEe4 and age with plasma MDS-OAβ revealed an AUC of 81% for abnormal amyloid PET status (95% CI, 74–87%). Plasma MDS-OAβ correlated negatively with MMSE (r = − 0.29, p < .01) and CSF Aβ42 (r = − 0.20, p < 0.05) and positively with CSF Tau (r = 0.20, p = 0.01).

Conclusions

Plasma MDS-OAβ combined with APOEe4 and age accurately identifies brain amyloidosis in a large Aβ-confirmed population. Using plasma MDS-OAβ as a screener reduced the costs and number of PET scans needed to screen for amyloidosis, which is relevant for clinical trials. Additionally, plasma MDS-OAβ levels appeared affected by long-term storage duration, which could be of interest for others measuring plasma Aβ biomarkers.
Viewpoint robust knowledge distillation for accelerating vehicle re-identification
Authors: Xie Yi , Shen Fei , Zhu Jianqing , Zeng Huanqiang
Published: July 2021

Vehicle re-identification is a challenging task that matches vehicle images captured by different cameras. Recent vehicle re-identification approaches exploit complex deep networks to learn viewpoint robust features for obtaining accurate re-identification results, which causes large computations in their testing phases to restrict the vehicle re-identification speed. In this paper, we propose a viewpoint robust knowledge distillation (VRKD) method for accelerating vehicle re-identification. The VRKD method consists of a complex teacher network and a simple student network. Specifically, the teacher network uses quadruple directional deep networks to learn viewpoint robust features. The student network only contains a shallow backbone sub-network and a global average pooling layer. The student network distills viewpoint robust knowledge from the teacher network via minimizing the Kullback-Leibler divergence between the posterior probability distributions resulted from the student and teacher networks. As a result, the vehicle re-identification speed is significantly accelerated since only the student network of small testing computations is demanded. Experiments on VeRi776 and VehicleID datasets show that the proposed VRKD method outperforms many state-of-the-art vehicle re-identification approaches with better accurate and speed performance.
Antifungal potential of cinnamon essential oils against Phytophthora colocasiae causing taro leaf blight
Authors: Hong Zhang , Talib Kalhoro Muhammad , Mujtaba Kalhoro Ghulam , Dabin Hou , Yahya Faqir , Congying Zhou , Fukai Wang
Published: July 2021

Background

Taro leaf blight, caused by a severely destructive oomycete fungusPhytophthora colocasiae, is responsible for threatening yield loss worldwide. The pathogen has the ability to germinate and spread rapidly to other plants during favorable conditions resulting in acute decline and even death, causing 100% crop loss. Farmers usually rely on highly toxic systemic fungicides to control the disease, which is effective, but residual effects and resistance of these agrochemicals is still a concern. Recently as returning to nature people tend to use chemical-free products, especially edible stuff produced in organic agriculture. Therefore, the use of bio-pesticides and phytochemicals is gaining special attention by scientists as they are ecofriendly non-hazardous, sustainable, and potent alternatives to control many virulent plant pathogens The present research was conducted to assess the antifungal potential of cinnamon essential oils againstP.colocasiae.

Materials and methods

The essential oils from cinnamon bark were extracted using microwave-assisted hydrodistillation equipment, and then their chemical constituents were evaluated using ATR FTIR spectroscopy. The antifungal potential of essential oil was assessed against mycelium, sporangia, zoospore, leaf necrosis, and corms lesions under laboratory conditions at, 0.156, 0.312, 0.625, 1.25, 2.5, 5.0 mg/mL concentrations. Hymexazol was used as positive control and no essential oil as negative control, while each treatment have three replications and experiment repeated twice.

Results

The main component of oil was identified as cinnamaldehyde. The pathogen isolated from infected taro leaves was identified asP.colocasiaeand then was used as a test fungus in the current study. Repeated experiments show maximum inhibition percentage of mycelial growth, zoospore germination, and sporulation of the fungus were observed at 0.625 mg/mL, whereas leaf necrosis was 100% inhibited at 1.25 mg/mL concentration.

Conclusion

This research can be a reference for easy, cost-effective and environment-friendly management and control of taro leaf blight with phytochemicals and plant essential oil derivatives.

Graphic abstract
Potential drug–drug interactions in patients with cardiovascular diseases: findings from a prospective observational study
Authors: Akbar Zarka , Rehman Sundas , Khan Asad , Khan Amjad , Atif Muhammad , Ahmad Nafees
Published: July 2021

Background

Patients with cardiovascular diseases (CVD) are at high risk of experiencing drug–drug interactions (DDIs). The objective of this study was to evaluate the frequency, level and risk factors associated with potential-DDIs (pDDIs) in hospitalized CVD patients at cardiology departments of two tertiary care hospitals in Quetta, Pakistan.

Methods

In the current prospective observational study, a total of 300 eligible CVD inpatients were evaluated for pDDIs using Lexicomp Interact®. The pDDIs were classified into class A (no known interaction); B (no action needed); C (monitor therapy: it is documented that the benefits of an interaction outweigh the risk, appropriately monitor therapy in order to avoid potential adverse outcomes); D (consider therapy modification: it is documented that proper actions must be taken to reduce the toxicity resulting from an interaction); X (avoid combination: the risk of an interaction outweighs the benefits and are usually contraindicated). Multivariate binary logistic regression analysis was used to find factors associated with the presence of Class-D and/or X pDDIs. A p-value < 0.05 was considered statistically significant.

Results

With a median of 8.50 pDDIs per patient, all patients (100%) had ≥ 1 pDDIs. Out of total 2787 pDDIs observed, 74.06% (n = 2064) were of moderate and (n = 483) 17.33% of major severity. Class C pDDIs were most common (n = 1971, 70.72%) followed by D (n = 582, 20.88%), B (n = 204, 7.32%) and X (n = 30, 1.08%). Suffering from cardiovascular diseases other than myocardial infarction (OR 0.053, p-value < 0.001) and receiving > 12 drugs (OR 4.187, p-value = 0.009) had statistical significant association with the presence of class D and/or X pDDIs.

Conclusion

In the current study, pDDIs were highly prevalent. The inclusion of DDI screening tools, availability of clinical pharmacists and paying special attention to the high-risk patients may reduce the frequency of pDDIs at the study sites.
Optimization of extraction conditions and evaluation of Manilkara zapota (L.) P. Royen fruit peel extract for in vitro α-glucosidase enzyme inhibition and free radical scavenging potential
Authors: Karle Pravin P. , Dhawale Shashikant C. , Navghare Vijay V. , Shivpuje Shivraj S.
Published: July 2021

Background

Most of the edible portions like peel and skin of some fruits is discarded while consuming it, though they are rich in several health beneficial phytochemicals or nutrients. Many reports from literature are about fruit pulp of (Sapota) Manilkara zapota (L) P. Royen having high radical scavenging and antioxidant potential, but the studies relating to peel extracts are scanty. Regardless of its commendable phytoconstituents which could have free radical scavenging potential, this fruit peel is as yet still needed to be assessed for in vitro antidiabetic prospects. Hence, the present study aims at evaluating in vitro free radical scavenging and α-glucosidase enzyme hindrance abilities of this fruit peel.

Results

With a maximum considerable % extractive yield (18.90%) in 70% ethanol, this study has demonstrated that 70% ethanolic extract of Manilkara Zapota (L.) P. Royen Fruit Peel (MZFP) has the highest in vitro free radical scavenging potential as compared to extracts of other solvents viz. n-hexane, chloroform, acetone, absolute ethanol, and water by DPPH and H2O2 assays. In order to optimize the extraction condition parameters, MZFP sample evaluated with three different concentrations of ethanol (40%, 70%, 100%), extraction times (6 h, 9 h, 12 h), and temperatures (40 °C, 50 °C, 60 °C) to get the highest radical scavenging potential. The MZFP when extracted with 70% ethanol, at 50 °C for 12 h, showed higher DPPH (IC50 = 0.34 and 88.42% inhibition at 1 mg/ml) and H2O2 (IC50 = 32.69 and 65.78% inhibition at 50 μg/ml) radical scavenging potential than absolute and 40% ethanolic extracts, when ascorbic acid was used as a reference standard. While further evaluation for in vitro α-glucosidase enzyme inhibition, 70% ethanolic MZFP extract demonstrated high inhibition activity (IC50 = 104.23 ± 1.75 μg/ml) than absolute ethanolic extract (IC50 = 111.65 ± 1.57 μg/ml) with a significant difference (p < 0.05), when acarbose was taken as reference inhibitor (IC50 = 86.93 ± 0.74 μg/ml).

Conclusions

Overall results indicated that MZFP 70% ethanolic extract exhibited promising in vitro radical scavenging and α-glucosidase enzyme inhibition potential. Thus, suggesting further studies with isolated phytochemicals from peel to explore its potentials for antidiabetic activity through in vitro α-glucosidase enzyme inhibition.
Minority status, stigma, prejudice and bullying: growing up in jeopardy
Authors: Skuse David
Published: July 2021

Stigma and alienation are suffered by many individuals with mental health disorders, in societies around the world. Rejection is all the more common among those who have intellectual disabilities or who are from ethnic minorities. In this issue, three papers consider the suffering experienced by patients with vulnerabilities that militate against their being in receipt of the psychiatric care they assuredly deserve.
Achievements and challenges in psychiatric education and training in Sri Lanka
Authors: Hapangama Aruni , Kuruppuarachchi K.A.L.A. , Hanwella Raveen
Published: July 2021

When compared with other Asian countries, psychiatric education and training in Sri Lanka has made significant developments during the past two decades, such as introducing psychiatry as a separate final year subject in the undergraduate medical curricula. However, further developments in psychiatric training in medical education are needed.
The Hard-Boiled Anthropocene and the Infrastructure of Extractivism
Authors: Rowan Jamin Creed
Published: July 2021

This essay suggests that hard-boiled crime fiction in the United States has developed the kind of “deep infrastructural ethic” that John Durham Peters says is present in much modern thought. The essay attempts to illuminate the genre’s infrastructural ethic and its corresponding affordance for environmental critique by tracing its expressions through a sample of significant texts in the hard-boiled and noir canons, and by concluding with a sustained reading of Paolo Bacigalupi’s The Water Knife (2015). These readings demonstrate that hard-boiled narratives enable readers to perceive the ways in which extractivist infrastructures are frequently built upon and facilitate the exploitation of both human and environmental resources. Hard-boiled texts help readers see capitalism’s extractivist infrastructure as a type of material and intellectual entrapment that ultimately undermines the common good and the planetary commons. Further, this essay argues that hard-boiled crime fiction attends to what AbdouMaliq Simone calls “infrastructures of relationality” and thus points a way out of the material and metaphysical entrapments of an extractivist economy’s infrastructure. The infrastructures of relationality that emerge in a world in which climate crises have broken down the infrastructures of capitalism provide a platform from which individuals can practice a mode of collective thinking and being that offers an alternative to the alienation upon which extractivism depends. In short, the hard-boiled genre is not only one of the Anthropocene’s earliest cultural responders but is also a vital genre for making sense of our contemporary situation in a deeper stage of the Anthropocene.
Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older Adults
Authors: BLANKENSHIP JENNIFER M. , WINKLER ELISABETH A. H. , HEALY GENEVIEVE N. , Dempsey PADDY C. , BELLETTIERE JOHN , OWEN NEVILLE , DUNSTAN DAVID W.
Published: July 2021

National guidelines recommend physically active interruptions to sitting time; however, the characteristics of these interruptions are broadly stated and ill-defined. A robust methodology for population surveillance for such interruptions is needed.

Purpose

To describe the frequency and characteristics (i.e., duration, stepping time, and estimated intensity) of all interruptions and physically active interruptions to adults’ free-living sitting time (i.e., transitions from sitting to upright posture) across segments of the population.

Methods

Australian Diabetes, Obesity and Lifestyle study participants (321 men; 406 women; mean ± standard deviation, 58.0 ± 10.3 yr) wore the activPAL3™ for ≥1 valid day. The characteristics of interruptions from laboratory studies demonstrating health benefits were selected to define active interruptions (≥5 min upright and/or ≥2 min stepping) and ambulatory interruptions (≥2 min stepping). The frequency and characteristics of all, active, and ambulatory interruptions were described and compared by age, sex, diabetes status, and body mass index.

Results

Adults averaged 55.0 ± 21.8 interruptions per day, but only 20.3 ± 6.7 were active and 14.0 ± 5.4 were ambulatory. Median (25th, 75th percentile) duration was 2.6 min (0.9, 7.8 min), stepping time was 0.8 min (0.3, 2.0 min), and estimated energy expenditure was 4.3 metabolic equivalents (MET)·min−1 (1.4, 12.5 MET·min−1). Those who were older, had obesity, or had diabetes had significantly (P < 0.05) fewer interruptions of all types and less stepping time during active interruptions than their counterparts (Cohen’s d < 0.2).

Conclusions

Free-living interruptions were often less active than interruptions performed in effective acute laboratory studies and their content varied widely between population groups. Monitoring all interruptions, as well as those that are more active, is advisable to provide a comprehensive understanding of free-living sedentary behavior.
Managerial Style and Attention
Authors: Dessein Wouter , Santos Tano
Published: July 2021

Is firm behavior mainly driven by its environment or rather by the characteristics of its managers? We develop a cognitive theory of manager fixed effects, where the allocation of managerial attention determines firm behavior. We show that in complex environments, the endogenous allocation of attention exacerbates manager fixed effects. Small differences in managerial expertise then may result in dramatically different firm behavior, as managers devote scarce attention in a way that amplifies initial differences. In contrast, in less complex environments, the endogenous allocation of attention mitigates manager fixed effects. Firm owners prefer “managers with style” only in complex environments. (JEL D21, D23, G34, M10, M31, M54)
Analysis of potential ECB effects from AI CP exposure
Authors: Kozyukov Aleksandr , Chubunov Pavel , Zolnikov Konstantin , Skvortsova Tatyana , Zhuravleva I.
Published: July 2021

The nature of the effect of radiation on a solid depends on the type, kinetic energy, mass and charge of the particles that make up this radiation, as well as on the mass, atomic number and density of the material. The article deals with the issues related to the physical models of the impact of ionizing radiation from outer space on the components of spacecraft equipment.
History and Recent Advances in Microsurgery
Authors: Yoo Hyokyung , Kim Byung Jun
Published: July 2021

Since the late 19th century, microsurgery has achieved many miracles in history of surgery. With the development of microsurgical instruments and techniques, especially the first operating microscope invented by Carl Zeiss in 1953, the limitations steadily decreased and finally reached a limitless level of today’s supermicrosurgery. The chronological history of microsurgery can be divided into four periods: the beginning period of the late 19th to early 20th century when the essential microsurgical tools and concepts were established; the successful replantation of amputated extremities in the 1960s; the development of various kinds of flap in the 1980s; and the fully-matured period of today. This article reviews the milestones in the history of microsurgery, evaluates the recent advances, as well as microsurgery in Korea.
Bottleneck Resources, Market Relatedness, and the Dynamics of Organizational Growth
Authors: Chang Sungyong , Eggers J. P. , Keum D. Daniel
Published: July 2021

Entering a new product market requires assembling a bundle of resources. Because missing a single resource can foil the entire entry effort, we argue that bottleneck resources—those most difficult to obtain or sell externally—anchor the direction of firm growth. We characterize market resources as bottlenecks to product market entry, because they are (on average) more challenging to obtain and sell than technological resources, and we articulate why the importance of market resources varies with the strength of external markets for technology. Using cross-industry data linking firms’ product portfolios with patents, we find resource dynamics whereby market resources drive the strategic decision to enter, and firms fill technological gaps using both internal research and development and external acquisitions (joint ventures and alliances). Our study underscores the importance of resources for firm growth dynamics and specifically highlights market resources as the bottleneck that constrains and directs the direction of product market entry.
Dual-broadband and single ultrawideband absorbers from the terahertz to infrared regime
Authors: Barzegar-Parizi Saeedeh , Ebrahimi Amir , Ghorbani Kamran
Published: July 2021

This paper presents the design and analysis of broadband metamaterial absorbers with single and dual absorption bands from terahertz to infrared frequencies. The absorbers are made of a composite graphene/metallic structure. A metallic patch array is printed on a ground-plane-backed dielectric slab. A graphene patch array is stacked on top of the metallic array, whereas a dielectric spacer separates the graphene and patch spacer from each other. The tunable property of the graphene surface conductivity at terahertz frequencies together with the complex permittivity of metal at the infrared regime are used to design broadband absorbers from the terahertz to infrared regime. The design is based on the combination and excitation of the plasmon polaritons of graphene and metallic patterned arrays at terahertz and infrared frequency bands, respectively. Two broad absorption bands occur from 4.56–9.02 THz and 16.95–60.23 THz with the fractional bandwidths of 67% and 112%, respectively. Furthermore, by a proper design of the parameters, a single ultrawide absorption spectra from 6.6–58.13 THz can be achieved with a fractional bandwidth 160%. In order to validate the simulation results, a circuit model-based analysis is developed, where the patterned arrays are modeled as the surface admittances, and the dielectric spacers are modeled by transmission line stubs. The results obtained by the full-wave simulations in the high-frequency structure simulator are in good agreement with the circuit model results. The absorbers show great stability with respect to the incidence angle for both the transverse electric and transverse magnetic waves.
Design and analysis of a multi-core whispering gallery mode bio-sensor for detecting cancer cells and diabetes tear cells
Authors: Chakrabarti Kisalaya , Obaidat Mohammad S. , Mostufa Shahriar , Paul Alok Kumar
Published: July 2021

Whispering gallery modes (WGM) have revolutionized the field of optical sensors. This paper presents a design and simulation of a novel structure called a “multi-core whispering gallery mode (WGM)” based on multiple evanescent waves coupling for detecting cancer cells and diabetes tear cells. This work is totally simulation based, and the simulation is done by a finite element method based simulation tool. From the simulation, it is expected that the proposed sensor exhibits a sensitivity of 650 nm/RIU, 666.67 nm/RIU, and 642.285 nm/RIU, respectively, for the detection of cancerous Basal, HeLa, and MDB-MB-231 cells. In addition, it is also capable of detecting affected diabetes tear cells from healthy tear cells with a sensitivity of 650 nm/RIU. To the best of our knowledge, the resultant sensitivity of the proposed sensor is probably the highest compared to other WGM based bio-sensors till now.
Evaluation of the paw withdrawal latency for the comparison between tramadol and butorphanol administered locally, in the plantar surface of rat, preliminary study
Authors: Interlandi Claudia , Leonardi Fabio , Spadola Filippo , Costa Giovanna Lucrezia
Published: July 2021

The aim of the study was to evaluate the analgesic efficacy of tramadol compared to butorphanol administered locally in ventral surface of the hind paw of rats. Prospective, randomized experimental study; twenty-one adult male Wistar rats were selected. Heart rate (beats minute-1), respiratory rate (breaths minute-1), and paw withdrawal latency (onset of radiant heat until paw withdrawal/seconds) were measured prior (T0) and after (T5, T10, T15, T20) intraplantar injection with saline solution 0,9% (group S), butorphanol 1 mg kg-1 (group B), and tramadol 1 mg kg-1 (group T). Shapiro-Wilk normality test and Friedman test were used to analyze the data expressed by median and range. Statistical significance was set at p < 0.05. Statistical analysis of heart rate showed that there were significant differences between groups at different monitoring times. There were no significant differences in respiratory rate after intraplantar injection in any of the treatment groups. The paw withdrawal latency values at T5, T10, and T15 minutes after intraplantar injection in the group B were significantly higher compared to baseline value and to the values of the other groups. The paw withdrawal latency were no significant changes in the measurements of intragroup in S and T. Intraplantar administration of butorphanol provides a good analgesia and significantly increases paw withdrawal latency compared to tramadol. Intraplantar injection of butorphanol could be useful and safe and safe technique to achieve local analgesia for minor surgical procedures in rats.
Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging
Authors: Alballa Tmader , Boone Edward L. , Ma Liangsuo , Snyder Andrew , Moeller F. Gerard
Published: July 2021

Past investigations utilizing diffusion tensor imaging (DTI) have demonstrated that cocaine use disorder (CUD) yields white matter changes, primarily in the corpus callosum. By applying Bayesian model averaging using multiple linear regression in DTI, we demonstrate there may exist relationships between the impaired white matter and glutamic acid decarboxylase (GAD) polymorphisms. This work explored the two-way and three-way interactions between GAD1a (SNP: rs1978340) and GAD1b (SNP: rs769390) polymorphisms and years of cocaine use (YCU). GAD1a was associated with more frontal white matter changes on its own but GAD1b was associated with more midbrain and cerebellar changes as well as a greater increase in white matter changes in the context of chronic cocaine use. The three-way interaction GAD1a|GAD1b|YCU appeared to be roughly an average of the polymorphism two-way interactions GAD1a|YCU and GAD1b|YCU. The three-way interaction demonstrated multiple regions including corpus callosum which featured fewer significant voxel changes, perhaps suggesting a small protective effect of having both polymorphisms on corpus callosum and cerebellar peduncle.
Arthroplasty implants and materials: Cost awareness and value perception
Authors: Gardezi Mursal , Ottesen Taylor D. , Tyagi Vineet , Sherman Josiah J. Z. , Grauer Jonathan N. , Rubin Lee E.
Published: July 2021

Arthroplasty procedures are commonly performed and contribute to healthcare expenditures seen in the United States. Surgical team members may make selections among implants and materials without always knowing their relative cost. The current study reports on a survey aimed to investigate the perceptions of an academic group about the relative cost and value of commonly used operating room implants and materials related to joint arthroplasty cases using 10 matched pairs of items. Of the 124 persons eligible to take the survey, 102 responded (response rate of 82.3%) including attendings, fellows, residents, physician assistants (PAs), advanced practice registered nurses (APRNs) and registered nurses (RNs). On average for the ten pairs of items, the more expensive items were correctly selected by 90.2+/-13.9% (mean+/- standard deviation) of respondents with a range from 54.9% to 100%. Of note, the cost differences were significantly overestimated for 8/10 item pairs. The majority of respondents perceived the more expensive item as the item with the higher clinical value for 9/10 item pairs. Most arthroplasty attendings (91.3%) indicated willingness to use the less expensive item of two similar items. Nonetheless, 17.9% of fellows, residents, PAs, APRNs and RNs indicated that they would not feel comfortable suggesting using the less expensive item. Although attending arthroplasty surgeons stated a desire to consider costs, a knowledge deficit with regards to identifying the extent of cost differences was identified, and a significant portion of the surgical support team reported being hesitant to suggest less expensive options.