bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Strategic Variables for the Development and Sustainability of Fos-Food Restaurant Business in the Pandemic Era; MICMAC Approach
Authors: Wati Lina Asmara , Lestariadi Riski Agung , Supriyadi Supriyadi , Safii Muhammad Permana Hendra
Published: January 2023

Talk about smart cities, the community's independence to open a business and drive the local economy is a concrete form in the community, which is useful in the current state. Even though in this Covid-19 pandemic condition, the life of a business is not easy, especially the seafood culinary business. A restaurant business requires a business development strategy that will determine the business's long-term future—this culinary tourism development and sustainability strategy. The MICMAC method functions analytically to solve systematic problems by developing sustainability strategies in industrial areas. So in this study, researchers will research Strategic Variable Analysis for the Development and Sustainability of the Fos-Food Restaurant Business in the Pandemic Era; MICMAC approach. This study uses primary and secondary data and uses the MICMAC method. The results of this study are: (1). The strategic factor analysis of Fos-Food Restaurant development has 11 strength variables, seven weakness variables, six opportunity variables, and eight threat variables. Based on the weighting and scores carried out, the total score for internal factors was 3.17 and for external factors was 3.07. (2). The research analyzed Fos-Food's development strategies and programs from the SWOT diagram, SWOT matrix, SWOT quadrant strategy analysis, and MICMAC analysis. The strategy analysis shows that the position of this restaurant is currently still in quadrant IV. Then the MICMAC analysis shows that judging from the indirect influence graph of each relationship between variables, the variables that have the greatest value are the variables: Financial and Accounting, Technological Environment, and Buyer/Customer Power.
Antibacterial Activity of Red Galangal (A. purpurata) Extract on the Growth of E. tarda Bacteria
Authors: Hidayati Desy Amalia , Prajitno Arief , Sulistyawati Titik Dwi , Pratama Giri , Nilakandhi Tania
Published: January 2023

This study aimed to analyze the antibacterial activity of red galangal extract (Alpinia purpurata) against the growth of E. tarda. This aims of this study was to determine the antibacterial compounds and the antibacterial effectiveness of red galangal extract (A. purpurata) against the growth of E. tarda bacteria. Antibacterial activity test was carried out by MIC test and disc test. The MIC test used doses of 1 ppm, 10 ppm, 100 ppm, 500 ppm, and 1000 ppm with incubation for 24 hours. The disc test used doses of 100 ppm, 200 ppm, 300 ppm, 400 ppm, 500 ppm and a positive control of 5 ppm chloramphenicol and a negative control without treatment. Photochemical test of red galangal extract (A. purpurata) contains flavonoid compounds, alkaloids, tannins, triterpenoids, and saponins. The results of the disc test showed that the highest inhibitory diameter was 7.55 mm at a dose of 500 ppm and was bacteriostatic because it decreased its inhibitory zone after 48 hours of incubation. The highest inhibitory effectiveness was 56.56% at a dose of 500 ppm after 24 hours of incubation.
The Utilization of Ketepeng Cina (Cassia alata L.) Leaves Ethanol Extract as a Prevention of Argulus japonicus Infestation to Gourami Fish (Osphronemus gouramy)
Authors: Pradipta Yudin Ardha , Kismiyati Kismiyati , Wulansari Putri Desi
Published: January 2023

This study aims to determine the benefits and optimal concentration of ketepeng cina leaves (Cassia alata L.) ethanol extract to prevent A. japonicus infestation in gourami fish. This research was conducted in May - August 2019. The research method used is the experimental method. This research design used Complete by Randomized Design (CRD ) with four concentration i.e. Control (P0), 209 ppm (P1), 418 ppm (P2), and 627 ppm (P3). Data was analyzed using Analysis of Variance (Anova) and then followed by Duncan’s Multiple Range Test (DMRT). The results showed that adding ketepeng cina leaves (Cassia alata L.) ethanol extract can prevent Argulus japonicus infestation on gourami fish at the concentration 627 ppm.
FORMULASI DAN EVALUASI EKSTRAK KULIT BATANG SECANG (Caesalpinia sappan L) SEBAGAI PEWARNA PADA SEDIAAN BLUSH ON GEL PATI KENTANG (Amylum solanni L)
Authors: Hanawara Neta
Published: January 2023

Blush on adalah jenis kosmetika dekoratif yang dapat digunakan untuk meningkatkan estetika dalam tata rias wajah. Tujuan penelitian ini adalah untuk memformulasi dan evaluasi sediaan blush on dalam bentuk semi padat menggunakan pati kentang sebagai gelling agent dan kulit batang secang sebagai pewarna. Kulit kayu secang yang mengandung pigmen braizilin,brailien dan senyawa flavonoid yaitu antosianin dalam jumlah yang besar sebagai pewarna. Pati kentang yang digunakan sebagai gelling agent memiliki nilai swelling power dan viskositas tinggi dibandingkan dengan pati lainnya. Pada formulasi konsentasi ekstrak kulit batang secang dibagi dalam 3 formula 1%, 3%, dan 6%. Tiap formula dilakukan pengujian selama 4 minggu pengujian yang dilakukan meliputi organleptik, homogenitas, pH, daya sebar, viskositas, , freeze thaw. Dari data hasil penelitian pada evaluasi sediaan blush on gel menunjukan stabilitas fisik blush on gel tidak mengalami perubah pada uji organoleptik, homogen tidak terdapat gumpalan, memiliki daya sebar 5 – 7,9 cm, pH yang dihasilkan 6,38 – 6,89, viskositas 2131 – 3029 cPs  dan tidak terjadi pemisahan fase. Berdasarkan hasil yang diperoleh dapat disimpulkan ekstrak kulit batang secang dapat digunakan sebagai pewarna alam pada sediaan kosmetik.
Artikel Text FORMULASI DAN EVALUASI SEDIAAN PEWARNA RAMBUT EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus Polyrhizus)
Authors: Farhanah Aulia
Published: January 2023

Salah satu jenis sediaan kosmetik yang digemari adalah pewarna rambut. Sediaan pewarna rambut adalah sediaan kosmetika yang digunakan dalam tata rias rambut untuk mewarnai rambut asalnya atau dengan warna lain. Tujuan penelitian ini ialah untuk memformulasi dan evaluasi sediaan pewarna rambut ekstrak kulit buah naga sebagai pewarna. Kulit buah naga memiliki unsur senyawa pewarna alami yang tinggi atau yang disebut antosianin, selain itu juga mengandung vitamin E yang  tinggi, Vitamin C, Vitamin A. Pada formulasi konsentrasi ektrak kulit buah naga dibagi menjadi 3 formula yaitu F1= 8%, F2 = 10%,  dan F3 = 12%. Evaluasi yang  dilakukan pada penelitian ini berupa pengujian organoleptik yang dinilai oleh dosen ahli dan pegujian pH. Hasil dari uji organoleptik ialah mendapatkan hasil kestabilan yang baik serta penelitian sediaan ini menghasilkan warna rambut dari merah tua hingga merah gelap. Penelitian ini menunjukan bahwa konsentrasi yang menghasilkan warna terbaik ialah formula 2 yang  menghasilkan warna merah keungu-unguan pada rambut. Dan pada uji pH menunjukan angka 4,5-5,0 sesuai dengan pH kulit rambut normal, berdasarkan hasil uji tersebut sediaan pewarna rambut ekstak kulit buah naga merah (Hylocereus Polyrizhus) aman digunakan dan dapat disimpulkan bahwa ekstrak kulit buah naga merah dapat digunakan sebagai pewarna alami pada sediaan kosmetik.
Artikel Text FORMULASI DAN EVALUASI SEDIAAN LIPSTIK EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)
Authors: Faradilla Jihan
Published: January 2023

Lipstik merupakan salah satu kosmetika dekoratif yang mana zat warna merupakan salah satu elemen terpenting dari formula lipstik. Penggunaan zat warna sintetik dalam sediaan lipstik dapat menimbulkan efek yang cukup berbahaya bagi kesehatan kulit. Salah satu bahan alternatif yang dapat digunakan yaitu buah naga merah (Hylocereus polyrhizus) sebagai pewarna alami dalam formulasi sediaan lipstik. Buah naga merah memiliki kandungan antioksidan yang tinggi dan juga mengandung pigmen antosianin yang dapat dimanfaatkan sebagai pewarna lipstik alami. Tujuan penelitian ini adalah untuk membuat sediaan lipstik dari ekstrak kulit buah naga merah (Hylocereus polyrhizus) sebagai pewarna alami dengan konsentrasi 5% (F1), 10% (F2), dan 20% (F3), dan mengetahui mutu sediaan lipstik dengan uji organoleptik dan uji pH. Hasil dari uji organoleptik menunjukan bahwa sediaan lipstik mempunyai kestabilan warna yang baik. Pada uji pH menunjukkan bahwa F1, F2, dan F3 memiliki rerata pH berturut-turut 4,6, 4,3, dan 4,1. Berdasarkan hasil uji tersebut, sediaan lipstik dari ekstrak kulit buah naga merah (Hylocereus polyrhizus) aman digunakan dan tidak menimbulkan reaksi negatif pada bibir.
HUBUNGAN LINGKUNGAN KELUARGA DAN MOTIVASI BELAJAR LIFE SKILL (TATA RIAS) SISWA SMP TERBUKA CAKUNG 1 JAKARTA TIMUR
Authors: Rahma Adiharsinta
Published: January 2023

ABSTRAK

Lingkungan keluarga merupakan lembaga pendidikan pertama dan utama. Terdapat faktor yang berpengaruh pada belajar siswa di lingkungan keluarga ialah: (1) Cara orang tua mendidik, (2) Suasana rumah, (3) Keadaan ekonomi keluarga, (4) Pengertian orang tua terhadap anak.  Perbedaan pendapatan keluarga dapat berpengaruh pada fasilitas dan prasarana belajar anak. Life skill Tata Rias memiliki peran penting dalam rangka membekali peserta didik agar dapat hidup secara mandiri. Hal ini bermaksud dapat memberi peluang mengetahui bakat minat siswa dan diharapkan dapat berguna apabila siswa harus terjun langsung ke dunia usaha, karena siswa memiliki pengalaman dan menguasai kompetensi produktif. Penelitian ini bertujuan unntuk mengetahui seberapa besar hubungan antara lingkungan keluarga dengan motivasi belajar life skill Tata Rias siswa SMP Terbuka Cakung 1 Jakarta Timur.

Penelitian ini merupakan penelitian korelasional dengan metode survei. Hasil penelitian ini menunjukan bahwa terdapat pengaruh positif lingkungan keluarga (X) terhadap motivasi belajar (Y) yang ditunjukkan dengan nilai koefisien korelasi (r) sebesar 0,633. Korefisien determinasi (R2) pada penelitian ini memnunjukkkan besar pengaruh lingkungan keluarga (X) terhadap motivasi belajar (Y) sebesat 40,1% dan sisanya sejumlah 59,9% dipengaruhi oleh faktor lain yang tidak diteliti oleh peneliti. Dengan perhitungan regresi linear sederhana diperoleh nilai koefisien regresi lingkungan keluarga (X) terhadap motivasi belajar (Y) sebesar 10,392 yang berarti setiap peningkatn lingkungan keluarga sebesar 1, maka motivasi belajar siswa akan meningkatkan sebesar 10,392. Dengan persamaan regresi dapat ditulis Y = 11.392 + 10.172X.

Kata Kunci: Motivasi Belajar, Lingkungan Keluarga, Life Skill, Tata Rias
Pemanfaatan Lidah Buaya (Aloe vera) Sebagai Bahan Baku Perawatan Kecantikan Kulit
Authors: Mardiana Mulia Ningsih Ajeng , Ambarwati Neneng Siti Silfi
Published: January 2023

Untuk perawatan kulit wajah lebih aman menggunakan cara perawatan yang tradisional dari bahan-bahan alami. Salah satu bahan alami yang digunakan untuk perawatan kulit wajah yaitu menggunakan tumbuhan lidah buaya (Aloe​ vera​). Berdasarkan hasil studi pustaka yang dilakukan oleh penulis, pemanfaatan dari tanaman lidah buaya (Aloe vera) sebagai salah satu tanaman perawatan kecantikan kulit yang sudah dikenal pemanfaatannya secara turun-temurun. Penulis menemukan lidah buaya dapat dimanfaatkan sebagai perawatan kesehatan dan kecantikan kulit seperti hand body lotion dan juga masker wajah yang alami. Teknik analisis data yang digunakan adalah analisis data kualitatif, dilakukan saat pengumpulan data berlangsung dan setelah selesai pengumpulan data sesuai dengan waktu yang ditetapkan. Mengacu pada model analisis interaktif yang diajukan oleh Miles dan Huberman, yang prosesnya berbentuk siklus yakni memperlihatkan sifat interaktif kolektif data atau pengumpulan data dengan analisis data.
Minat Beli Serum Bulu Mata Melalui Media Sosial Instagram
Authors: Erfina Nurfitria Rifani  , Ambarwati Neneng Siti Silfi
Published: January 2023

ABSTRACT

ERFINA NURFITRIA RIFANI. Interest in Buying Eyelash Serum via Instagram Social Media. Jakarta. Diploma Three Makeup Study Program, Faculty of Engineering, Jakarta State University, 2021.

This study aims to found out how interest in buying eyelash serum through social media for students of the D3 Makeup Program 2019 Jakarta State University. This research was made using quantitative descriptive methods by distributing questionnaires to students of the D3 Makeup program 2019 at Jakarta State University. Based on theoretical studies and data collection conducted in this study, itu produces 81,11%.
Hubungan Tingkat Pengetahuan Kosmetika dengan Perilaku Menghindari Kosmetika yang Mengandung Rhodamin-B
Authors: Karuniawaty Aldes
Published: January 2023

Kosmetik merupakan kebutuhan yang telah lama digunakan dan dikembangkan oleh manusia. Seiring perkembangan zaman penggunaan kosmetikkian meningkat, Mahasiswi sebagai konsumen yang menggunakan produk kosmetika seharusnya memiliki pengetahuan yang baik mengenai kosmetika. Kosmetika yang beredar di pasaran sangat beragam baik merek, jenis, kegunaannya, maupun warna dan bentuknya. Penelitian ini bertujuan untuk Mengetahui Hubungan pengetahuan dengan perilaku menghindari Kosmetika yang mengandung Rhodamin-B. Penelitian ini menggunakan metode penelitian deskriptif dengan pendekatan korelasional serta sampel penelitian ini adalah Mahasiswa Pendidikan Tata Rias angkatan 2018 berjumlah 30 dengan menggunakan random sampling. Data yang digunakan adalah data primer yang didapatkan melalui kuesioner. Uji persyaratan analisis yang digunakan dalam penelitian ini adalah Uji Normalitas Kolmogorov-Smirnov yang menunjukkan nilai probabilitas (Sig.) sebesar 0,080 untuk variabel pengetahuan kosmetika (X) dan 0,198 untuk variabel perilaku menghindari kosmetika yang mengandung Rhodamin-B (Y) perolehan kedua skor tersebut didapat > 0,05 taraf signifikan, sehingga kedua variabel dapat dinyatakan berdistribusi normal. Pengujian hipotesis pada penelitian ini menggunakan uji koefisien korelasi product moment dan uji keberartian koefisien korelasi. Hasil menunjukkan r hitung sebesar 0,625, yang artinya lebih besar dari r tabel yaitu 0,361, yang berarti Ho ditolak dan Ha diterima.Nilai korelasi sebesar 0,625 menunjukkan korelasi yang kuat, hal ini mengacu terhadap Tingkatan Koefisien Korelasi. Dapat disimpulkan bahwa terdapat hubungan positif antara pengetahuan kosmetika dengan perilaku menghindari kosmetika yang mengandung Rhodamin-B.
Persepsi Masyarakat Terhadap Manfaat Akupunktur Untuk Mengatasi Kerontokan Rambut
Authors: Salsabila Nazhifah
Published: January 2023

Penelitian ini bertujuan untuk mengetahui sejauh mana persepsi masyarakat terhadap manfaat akupunktur untuk mengatasi kerontokan rambut. Populasi penelitian ini adalah masyarakat yang terapi akupunktur untuk mengatasi kerontokan rambut dengan jumlah sampel penelitian adalah 30 responden. Penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Metode yang digunakan dalam penelitian ini adalah metode survei. Teknik sampling yang digunakan adalah Purposive Sampling. Instrumen yang digunakan adalah kuesioner tertutup untuk pengumpulan data, guna mendapat gambaran tentang indikator pengetahuan, kebutuhan, dan pengalaman masyarakat terhadap manfaat akupunktur untuk mengatasi kerontokan rambut. Pengujian instrumen dengan uji validitas menggunakan rumus Product Moment. Uji reliabilitas menggunakan rumus Alpha Cronbach. Teknik analisis data dilakukan dengan menggunakan teknik deskriptif kuantitatif dengan presentase. Hasil penelitian ini menunjukkan bahwa persepsi masyarakat terhadap manfaat akupunktur untuk mengatasi kerontokan rambut berdasarkan persepsi pengetahuan termasuk dalam kategori sangat tinggi dengan skor nilai 848, pada persepsi kebutuhan termasuk dalam kategori tinggi dengan skor nilai 699, dan persepsi pengalaman termasuk dalam kategori tinggi dengan skor nilai 1195. Dapat disimpulkan bahwa persepsi masyarakat terhadap manfaat akupunktur untuk mengatasi kerontokan rambut dilihat dari berbagai indikator adalah tinggi (bermanfaat) dimana kerontokan rambut berkurang dan pertumbuhan rambut lebih baik.
PENGEMBANGAN LEARNING MANAGEMENT SYSTEM (LMS) SEBAGAI MEDIA PEMBELAJARAN UNTUK SEKOLAH MENENGAH SEDERAJAT
Authors: Septia Fandy
Published: January 2023

Penelitian ini menggunakan Metode penelitian dan pengembangan (Research and Development) juga didefinisikan sebagai penelitian yang secara sengaja, sistematis, bertujuan/diarahkan untuk mencaritemukan, merumuskan, memperbaiki, mengembangkan, menghasilkan, menguji keefektifan produk, model, metode/strategi/cara, jasa, prosedur tertentu yang lebih unggul, baru, efektif, efisien, produktif, dan bermakna. Model pengembangan yang digunakan adalah model pengembangan 4D, 4D model ini terdiri dari 4 tahap utama yaitu, define (pendefinisian), design (perencanaan), development (pengembangan), dan disseminate (penyebaran). Learning Management System (LMS) dikembangkan sebagai media pembelajaran menggunakan open source yang telah tersedia. Diharapkan dapat menarik perhatian siswa, memberikan motivasi pada siswa, dan disesuaikan dengan minat siswa sehingga diharapkan informasi yang disampaikan melalui media tersebut dapat ditangkap oleh siswa dan diujicobakan pada proses belajar mengajar untuk melihat kepraktisan penggunaan Learning Management System (LMS). LMS mempunyai ruang lingkup administrasi, penyampaian materi, penilaian, monitoring, dan komunikasi. Materi-materi dalam kompetensi pedagogik dan profesional, yang dibuat dengan kemasan multimedia (teks, animasi, video, sound) yang ada dalam LMS akan mempercepat (akselerasi) penguasaan ilmu pengetahuan dan teknologi yang dapat meningkatkan kualitas pembelajaran secara optimal.
Emerging Minimally Invasive Percutaneous Procedures for Periacetabular Osteolytic Metastases
Authors: Ibe Izuchukwu , Dussik Christopher M. , Callan Alexandra K. , Barr Jennifer , Lee Francis Y.
Published: January 2023

➤ Periacetabular osteolytic skeletal metastases are frequently associated with pain and impaired ambulatory function. Minimally invasive techniques allow for the restoration of ambulation without interrupting critical systemic cancer therapy.

➤ The open surgical management of massive periacetabular osteolytic lesions, such as by curettage, internal fixation, or complex total hip reconstruction, is associated with blood loss, hospitalization, rehabilitation, and complications such as infection or delayed wound-healing.

➤ Minimally invasive percutaneous procedures have become increasingly popular for the management of periacetabular osteolytic metastases by interventional oncologists and orthopaedic surgeons before complex open surgical procedures are considered.

➤ Minimally invasive procedures may include various methods of cancer ablation and reinforcement techniques. Minimally invasive procedures may entail cancer ablation, polymethylmethacrylate (PMMA) cement reinforcement, balloon osteoplasty, percutaneous screw fixation, or combinations of the aforementioned techniques (e.g., ablation-osteoplasty-reinforcement-internal fixation [AORIF]).
Pengaruh kemajuan teknologi informasi terhadap perkembangan akuntansi
Authors: Fauzi Eric , Visar Sinatrya Muhammad , Daru Ramdhani Nanda , Ramadhan Ruhuphy , Muhammad Rasid Safari Zaid
Published: January 2023

Technology that develops rapidly causes significant changes in the accounting field. These changes require accountants to continue to follow developments and improve their competence. Historically, the development of accounting has been divided into three eras, starting from the farming era and then the industrial era to the present, namely the information age. The more advanced information technology (IT), the more influence it will have on the accounting field. One of the effects of IT progress can be seen in the development of accounting information systems (AIS) in terms of processing data, internal control, and increasing the amount and quality of information in financial reporting. The development of computer-based AIS in producing financial reports also has an impact on the audit process. Although at first it gave the accounting profession a sense of worry, the development of IT in the end provided new opportunities for the accounting profession. The new opportunities that can be achieved include computer-based information system audits, computer-based information system consultants and web trust audits. Advances in IT brought significant changes to the development of accounting and also brought many benefits for both employees and companies.
Analisis perbandingan PSAK 55 dan PSAK 71 pada PT bank negara indonesia (persero) Tbk
Authors: Fatiha Kurniadi Aulia , Ayu Rahmanissa Lathifah , Hasnah Rosydah Leila , Astari Angraini Putri , Rudila Putri Yolanda
Published: January 2023

This study aims to examine the comparison of PSAK 55 and PSAK 71 and their impact and implementation on PT Bank Negara Indonesia (BNI) Tbk. The descriptive qualitative method which is explanatory research with a literature study approach and content analysis is the research method used. In this study, secondary data is the data used which takes data and information from the annual financial statements of Bank BNI sourced from the BEI website. The results of the study are the impact of the enactment of PSAK 71 which lies in the measurement and grouping of financial assets, as well as the calculation of CKPN which was originally calculated based on historical data to be forward looking.
Precambrian–Cambrian Transition at the Igarka Uplift (Northwestern Siberian Platform)
Authors: Marusin V.V. , Kochnev B.B. , Karlova G.A. , Izokh O.P. , Sarsembaev Zh.A. , Ivanova N.A.
Published: January 2023

—The Precambrian–Cambrian transition is one of the most fundamental evolutionary turnovers in the Earth’s history. However, in many cases precise identification and correlation of this crucial boundary in lithologically contrasting sections is complicated, even if the whole spectrum of biostratigraphic and chemostratigraphic methods is applied. The Precambrian–Cambrian transitional strata of the Igarka Uplift (Sukharikha Formation) perfectly illustrate this problem. This unit has arguably one of the most detailed carbonate carbon isotope curves for this time interval (at least within the Siberian Platform). However, an extremely poor paleontological record previously reported from the Sukharikha Formation makes identification of major stratigraphic boundaries highly debatable. We present a detailed study of the Sukharikha and overlying Krasnyi Porog formations in three sections (Sukharikha River, Kulyumbe River, and Khantaisko-Sukhotungusskaya-1 well). Our chemostratigraphic and biostratigraphic data provide a correlation basis for these sections and identify the Cambrian boundary in terms of both the International Chronostratigraphic Chart and General Stratigraphic Scale of Russia. We show that lithologic boundaries and levels of the local first appearance of Tommotian small skeletal fossils are diachronous within the Igarka paleobasin. The latter is putatively caused by paleoecology of the early Cambrian biota and by taphonomic factors. Our data specify the location of the Tommotian Stage (sensu lato)/Cambrian Stage 2 boundary in other key Precambrian–Cambrian transitional sections of the Siberian Platform.
Plan de negocios para la venta de Eco-Bungalows en contenedores marítimos en Lima Metropolitana
Authors:   , Cabezas Vilchez Corali , Mendoza Garcia Francisca del Rosario , Crovetti Vidales Roberto Eugenio , Berrocal Pachas Jim Sebastian , Mamani Quispe Karen Yessenia
Published: January 2023

En el presente Business Plan, se va a presentar los siguientes capítulos que conforman el proyecto de inversión para la idea de negocio “VENTA DE ECO-BUNGALOWS EN CONTENDEDORES MARÍTIMOS EN LIMA METROPOLITANA”, que se va a desarrollar en el giro de construcción e inmobiliario. El siguiente Business Plan, es el resultado de un profundo análisis de los factores tanto internos y externos del sector actual, que permiten identificar cuáles eran los principales “insights” o variables claves de mercado. Así mismo, a partir de la elaboración de cada capítulo, se pudieron establecer las estrategias generales y específicas para cumplir con los objetivos trazados a corto plazo y largo plazo, con la finalidad de poder alcanzar un retorno de inversión en el menor tiempo posible que genere alto valor en el tiempo para nuestros inversionistas. Las estrategias sugeridas en el planeamiento se centran en apalancarse del diseño innovador, funcional a partir de la implementación de contenedores marítimos de 20´ST y 40´HC con alto valor de reutilización y tiempos cortos de entrega, como ventaja competitiva principal a diferencia de los principales competidores que ofrecen estructuras convencionales. Por último, el plan de negocio a continuación está elaborado con miras a crecer de forma sostenible, innovadora y rentable por arriba del sector, el cual está teniendo una demanda contraria debido a factores tales como el déficit de construcción a nivel país, costos por materiales convencionales, y tiempos prolongados en ser los propietarios y/o usuarios.
Plan de negocio para la producción, comercialización y exportación de maca gelatinizada al mercado de Estados Unidos
Authors:   , Cabrera Pacheco Daniella Roxana , Derteano Gomez Priscilla , Morante Palacios Yanara Maritriny , Gamarra Flores Rody Justo , Paredes Fuentes Joel Victor Eusebio
Published: January 2023

En el presente trabajo desarrollaremos un plan de negocio de producción, comercialización y distribución de maca gelatinizada ejecutado en San Juan de Lurigancho, específicamente en Santa María de Huachipa, donde daremos a conocer nuestro producto que es la Maca Gelatinizada, constituido como empresa de nombre Maca Gelato S.A.C. El producto de distribución indirecta de 2°grado será exportado a EE.UU, los distribuidores establecen los principales puntos estratégicos como son los supermercados, minimarket’s y ferias orgánicas. En la parte inicial de nuestra investigación desarrollamos la propuesta de negocio, identificando el mercado objetivo y ajustando los parámetros necesarios para cubrir la demanda del producto. En el capítulo 2, efectuamos el análisis del entorno, tanto a nivel interno como externo. Continuando con el siguiente capítulo, nos concentramos en el Plan Estratégico de nuestro emprendimiento, estableciendo su visión, misión, valores, objetivos, su estrategia y las ventajas competitivas. En el cuarto capítulo, estructuramos a Maca Gelato con un minucioso Estudio de Mercado, en donde establecemos a EEUU como nuestro mercado potencial, ya que exportaremos maca gelatinizada e implica búsqueda de certificaciones actuales para ingresar a nuevos mercados extranjeros. En el capítulo quinto, estableceremos el Marketing Mix y las estrategias a efectuar, donde enfatizamos la estrategia a usar para posicionarnos en los mercados extranjeros. En el capítulo sexto y séptimo detallaremos cuáles son los procesos y actividades que ejecutaremos seguido por el costo de capital humano estableciendo nuestra estructura organizacional, las políticas de sueldos establecidas y el coste por área. Posteriormente, en el capítulo octavo detallamos los aspectos legales y tributarios. Seguido del capítulo noveno detallando el plan de TI y la mejor propuesta de ERP. Finalmente, el capítulo décimo, mostramos el plan financiero que brinda la viabilidad del proyecto, los costos, la rentabilidad, la generación de utilidades luego de cumplir las deudas de inversión.
Identificación de bacterias de la familia Enterobacteriaceae en pollos de engorde suplementados con diferentes aditivos comerciales
Authors:   , Pacsi Muñoz Elizabeth Katherine
Published: January 2023

Con el objetivo de determinar los patógenos bacterianos oportunistas de la familia Enterobacteriaceae aislados en pollos de engorde suplementados con un diferentes aditivos comerciales, se emplearon 320 pollos machos (Cobb 500) que fueron alojados aleatoriamente en 4 tratamientos, con 4 repeticiones y 20 pollos por repetición. Los tratamientos experimentales fueron los siguientes; dieta control que contenía una basal estándar sin aditivos (DCSA), dieta basal con extracto de plantas (DEP), dieta basal con probióticos (DPB) y dieta con antibiótico promotor de crecimiento (DAPC). Las evaluaciones se realizaron en tres 3 fases; de 1 a 10 días, de 11 a 20 días y de 20 a 42 días de edad. Al final de cada fase fueron sacrificados 2 pollos por repetición. Se realizó el aislamiento bacteriano directamente de la mucosa intestinal del intestino delgado. Las muestras se tomaron por duplicado, se aislaron usando protocolos de aislamiento microbiológico establecidos para enterobacterias de la familia Enterobactereaceae. Las muestras fueron procesadas en agar Mac Conkey y XLD (xilosa, lisina, desoxicolato) e identificadas con pruebas bioquímicas correspondientes; para las muestras del aislamiento para hallar Salmonella spp. fueron previamente sembradas en caldo de cultivo RVS (Rappaport – Vassiliadis – Soya) y luego procesadas en agar XLD (xilosa, lisina, desoxicolato) además se evaluó el crecimiento tardío según la metodología empleada para esta enterobacteria. Las enterobacterias encontradas fueron; Enterobacter spp., Escherichia Coli y Proteus spp. En este estudio no hubo presencia de Salmonella spp. Los resultados mostraron que los pollos del grupo DEP y DPB presentaron menor porcentaje de bacterias intestinales, seguida del grupo de aves con la dieta DCSA. A los 10 días de edad las aves DEP y DPB presentaron 0% de Enterobacter spp
Plato’s Theory of the Elemental Bodies in the Timaeus
Authors:   RAS Institute of Philosophy, Volkova Nadezhda P.
Published: January 2023

This article focuses on problems of interpretation of Plato’s theory of the elemental bodies in the Timaeus. The purpose of the study is to present Plato’s doctrine of the elements as particles consisting of primary triangles. Our special attention will be given to the following topics. First, to the question of the pre-cosmic state of the elemental bodies, namely: (1) whether the elements were qualities of the receptacle or independent powers (δυνάμεις), (2) what language of description Plato considers preferable (i.e. whether it is worth calling them by names “fire”, “water”, etc.), (3) whether the elements were images of forms and (4) had a corpuscular structure. Second, to the question concerning primary triangles from which the surfaces of the elemental bodies are constructed: (1) are they bodies or not, (2) in what relation do they stand with the nature of the receptacle, and (3) whether they differ in size. And third, to the question of the correspondence of the forms of the elements with their natural properties. We show that (1) the elements were always thought of by Plato as images of intelligible forms and had a corpuscular structure, (2) that all the secondary properties of the elements are reduced to their geometric structure, (3) that the primary triangles are the same bodies as the elements, (4) that the primary triangles are not identical with the receptacle and (5) differ from each other in species but do not vary in size within each species.
The Reality of the Jews (Fragments)
Authors: Goldberg Oscar
Published: January 2023

Goldberg, Oskar. “The Reality of the Jews (Fragments).” Translated and commented by Konstantin Yu. Burmistrov. History of Philosophy Yearbook / Istoriko-filosofskii ezhegodnik 37 (2022): 417–433. (In Russian)
"One -step method" laparoscopic bile tube detection+laparoscopic cholecystectomy treatment
Meta analysis of gallbladder stones with gallbladder chassis stones
Authors: Ding Wei , Yan Sheng
Published: January 2023

Objective
Analyze the "one -step method" laparoscopic biliary tube detection (LCBDE) combined with laparoscopic gallbladder sinking (LC) to treat the effects and safety of gallbladder stones with bile stones (CBDS).
Methods
Retrieve Chinese and English databases, collect LCBDE combined with LC to treat gallbladder stones with clinical random control research (RCT). Essence The ending indicators include CBD clearing stones, transit opening rates, stones residual rates, stones recurrence rates, postoperative complications, and postoperative hospitalization.
Results
This study has been included in 21 documents. Two groups of CBD Qingshi (OR = 0.78, 95%CI: 0.49, 1.25), stones residue rate (or = 0.73, 95%CI: 0.34, 1.56) There is no statistical difference. The recurrence rate of "one -step method" is significantly lower than the "two -step method" (or = 0.37, 95%CI: 0.20, 0.69), the total incidence of complications was significantly lower (or = 0.66, 95%CI: 0.52, 0.84), shorter after surgery (WMD =−1.07D, 95%CI:−2.00,−0.14).
Conclusion
The "one -step method" LCBDE combined with LC treatment of gallbladder stones and CBDS effects are equivalent to ERCP/EST sequential LC, but their postoperative complications have fewer complications. Patients recovery after surgery are a more ideal choice.
Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis
Authors: Lavine Kory , Amrute Junedh , Luo Xin , Penna Vinay , Bredemeyer Andrea , Yamawaki Tracy , Yang Steven , Kadyrov Farid , Heo Gyu , Shi Sally , Lee Paul , Koenig Andrew , Kuppe Christoph , Jones Cameran , Kopecky Benjamin , Hayat Sikander , Ma Pan , Terada Yuriko , Fu Angela , Furtado Milena , Kreisel Daniel , Stitziel Nathan , Li Chi-Ming , Kramann Rafael , Liu Yongjian , Ason Brandon
Published: January 2023

Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction. However, the molecular mechanisms driving immune-fibroblast crosstalk in human cardiac disease remains unexplored and there are currently no therapeutics to target fibrosis. Here, we performed multi-omic single-cell gene expression, epitope mapping, and chromatin accessibility profiling in 38 donors, acutely infarcted, and chronically failing human hearts. We identified a disease-associated fibroblast trajectory marked by cell surface expression of fibroblast activator protein (FAP), which diverged into distinct myofibroblasts and pro-fibrotic fibroblast populations, the latter resembling matrifibrocytes. Pro-fibrotic fibroblasts were transcriptionally similar to cancer associated fibroblasts and expressed high levels of collagens and periostin (POSTN), thymocyte differentiation antigen 1 (THY-1), and endothelin receptor A (EDNRA) predicted to be driven by a RUNX1 gene regulatory network. We assessed the applicability of experimental systems to model tissue fibrosis and demonstrated that 3 different in vivo mouse models of cardiac injury were superior compared to cultured human heart and dermal fibroblasts in recapitulating the human disease phenotype. Ligand-receptor analysis and spatial transcriptomics predicted that interactions between C-C chemokine receptor type 2 (CCR2) macrophages and fibroblasts mediated by interleukin 1 beta (IL-1β) signaling drove the emergence of pro-fibrotic fibroblasts within spatially defined niches. This concept was validated through in silico transcription factor perturbation and in vivo inhibition of IL-1β signaling in fibroblasts where we observed reduced pro-fibrotic fibroblasts, preferential differentiation of fibroblasts towards myofibroblasts, and reduced cardiac fibrosis. Herein, we show a subset of macrophages signal to fibroblasts via IL-1β and rewire their gene regulatory network and differentiation trajectory towards a pro-fibrotic fibroblast phenotype. These findings highlight the broader therapeutic potential of targeting inflammation to treat tissue fibrosis and restore organ function.
Bioactive multi-protein adsorption enables targeted mast cell nanotherapy
Authors: Du Fanfan , Rische Clayton , Li Yang , Vincent Michael , Krier-Burris Rebecca , Qian Yuan , Yuk Simseok , Almunif Sultan , Bochner Bruce , Qiao Baofu , Scott Evan
Published: January 2023

Proteins readily and often irreversibly adsorb to nanomaterial surfaces, resulting in denaturation and loss of bioactivity1,2. Controlling this process to preserve protein structure and function has remained an elusive goal that would enhance the fabrication and biocompatibility of protein-based bioactive nanomaterials3-7. Here, we demonstrate that poly(propylene sulfone) (PPSU)8 nanoparticles support the controlled formation of multi-component enzyme and antibody coatings while maintaining their bioactivity. Simulations indicate that hydrophobic patches9 on protein surfaces induce site-specific dipole relaxation on PPSU surfaces to noncovalently anchor proteins without disrupting hydrogen bonding or protein structure. As proof-of-concept, a nanotherapy for enhanced antibody-based targeting of mast cells and inhibition of anaphylaxis3,4 is demonstrated in a humanized mouse model. The ratio of co-adsorbed anti-Siglec-610,11 and anti-FcεRIα antibodies is systematically optimized to effectively inhibit mast cell activation and degranulation. Protein immobilization on PPSU surfaces therefore provides a simple and rapid platform for the development of targeted nanomedicines.
An Optical Logic Gate Based On 2-Dimensional Photonic Crystals with High Operating Contrast Ratio And Fast Response Time
Authors: DERDOUR ROUMAISSA , Lebbal Mohamed Redha , Mouetsi Souheil
Published: January 2023

An optimized all-optical "NAND" logic gate is studied analytically. The particular characteristic of this logic gate is that it is based on photonic crystals, it consists of a resonator coupled with two waveguides on a silicon substrate. The operating wavelength is equal to 1.55µm which represents the telecommunication wavelength, the switching power of the optical logic gate studied is 1.693 kw /µm2 its response is independent of the response of the resonator when the power intensity of the optical waves is lower than the resonance wavelength, the light will be coupled in the waveguides, in the opposite case the light propagates in the waveguide of the bus.
Serum zinc in patients with colorectal cancer might contribute to the prediction of tumor clinical staging scores： a prospective single-center clinical study
Authors: Zhang Chenlong , Zhang Yumei , Wang Yujie , Guo Kaihang , Li Pengfei , Zhang Chunfang , An Hanxiang , Huang Lairong
Published: January 2023

Background: Diagnosis for colorectal cancer is infrequently diagnosed and not accurate staging. Trace elements may be involved in the whole process of intestinal tumors. Can trace elements be used to predict condition and staging scores for colorectal cancer?
Methods: Patients(n=74) and the control group (n=32) were enrolled. Data from the first acceptance were recorded including age, gender, clinical staging scores of tumors, and tumor biomarkers. The serological specimens were tested for magnesium, iron, copper, zinc, calcium, and selenium with ICP-MS. T-test was used to analyze serum trace elements in patients and the control group, and LASSO regression was executed to screen which factors contributed most to clinical staging scores.
Results: The level of copper in the control group is lower than in the patients (p=0.0004, ∆mean±SEM=210.7±57.79, and 95%CI=96.14to325.4). For the other five trace elements in the control group is higher than in the patients, respectively manganese (p=0.0003, ∆ mean±SEM=-1.658±0.4470, 95%CI=-2.544to-0.7713), iron (p=0.0343, ∆ mean=-0.3672±0.1712, 95%CI=-0.7068to-0.02761), zinc (p=0.0059, ∆ mean=-0.1348±0.04794, 95%CI=-0.2298to-0.03968), calcium (p<0.0001, ∆ mean=-15.10±3.482, 95%CI=-22.00to-8.195), selenium (p=0.0216, ∆mean=-12.23±5.242, 95%CI=-22.62to-1.832). The results of LASSO regression show variables selected are Ca125 （ coefficient=5.8e-04 ） , Ca199 （coefficient=7.4e-05）, zinc（coefficient=-0.2047） ， and intercept（3.1951）, which are regarded as the most contributing to the clinical staging scores， the coefficients for other factors are zero.
Conclusions: Ca125 and Ca199 are positively contributing to the clinical staging scores, and zinc is negatively correlated with them. Therefore, we suggest that serum zinc might be used to predict the clinical staging scores of patients with colorectal cancer.
Native microbiome dominates over host factors in shaping the probiotic genetic evolution in the gut
Authors: Jiang Shuaiming , Zhang Chengcheng , Han Zhe , Ma Wenyao , Wang Shunhe , Huo Dongxue , Cui Weipeng , Zhai Qixiao , Huang Shi , Zhang Jiachao
Published: January 2023

Probiotics often acquire adaptive mutations in vivo gaining new functional traits through gut selection. However, it remains challenging to separate microbiome and host contribution to such selective pressures. Here, we tracked and compared the temporal genetic evolution of representative probiotic strains in germ-free (GF) and specific-pathogen-free (SPF) mice. Notably, host only elicited < 15 probiotic mutations, < 0.25% of those derived from both factors that was never captured by other experimental evolution studies, indicating that keen microbial competitions exhibited the predominant evolutionary force in shaping probiotic genetic composition (> 99.75%). Furthermore, native microbiome consistently drove a more rapid and divergent genetic evolution of probiotic strains in seven days of colonization than host factors did. Our study further laid a theoretical foundation for genetically engineering probiotics for better gut adaptation through in vitro artificial gut ecosystems without the selection pressures derived from host factors.
Non-invertible higher-categorical symmetries
Authors: Bhardwaj Lakshya , Bottini Lea E. , Schäfer-Nameki Sakura , Tiwari Apoorv
Published: January 2023

We sketch a procedure to capture general non-invertible symmetries of
a dd-dimensional
quantum field theory in the data of a higher-category, which captures
the local properties of topological defects associated to the
symmetries. We also discuss fusions of topological defects, which
involve condensations/gaugings of higher-categorical symmetries
localized on the worldvolumes of topological defects. Recently some
fusions of topological defects were discussed in the literature where
the dimension of topological defects seems to jump under fusion. This is
not possible in the standard description of higher-categories. We
explain that the dimension-changing fusions are understood as
higher-morphisms of the higher-category describing the symmetry. We also
discuss how a 0-form sub-symmetry of a higher-categorical symmetry can
be gauged and describe the higher-categorical symmetry of the theory
obtained after gauging. This provides a procedure for constructing
non-invertible higher-categorical symmetries starting from invertible
higher-form or higher-group symmetries and gauging a 0-form symmetry. We
illustrate this procedure by constructing non-invertible 2-categorical
symmetries in 4d gauge theories and non-invertible 3-categorical
symmetries in 5d and 6d theories. We check some of the results obtained
using our approach against the results obtained using a recently
proposed approach based on ’t Hooft anomalies.
BRAIN METASTASIS FROM UTERINE CERVICAL CANCER
Authors:   Department of Gynecology Obstetric I, University Hospital Hassan II Fez., Khadija Bouras , Fatiha Ouakka ,   University Sidi Mohammed Ben Abdallah, Fez, Morocco., a Saoudkaram ,   Department of Gynecology Obstetric I, University Hospital Hassan II Fez., Nisserine Mamouni ,   Department of Gynecology Obstetric I, University Hospital Hassan II Fez., Sanae Erraghay ,   Department of Gynecology Obstetric I, University Hospital Hassan II Fez., Chahraza Bouchikhi ,   Department of Gynecology Obstetric I, University Hospital Hassan II Fez., Abdelaaziz Banani ,   University Sidi Mohammed Ben Abdallah, Fez, Morocco.
Published: January 2023

Uterine cervical cancer usually spreads by local extension and through the rich lymphatic network to the retroperitoneal lymph nodes. However, brain metastasis from primary cervical cancer is extremely rare. They are usually seen late in the clinical course and have poor prognosis. We present a52-year-old woman with squamous cell carcinoma of the cervix who developed brain and other multiple metastases after 8-month treatment of the primary disease. The patient showed up neurologic symptoms and received one session of brain radiation therapy and steroids, then she died one month later.
SPATIALLY EXPLICIT ASSESSMENT OF THE SUITABLE AREAS FOR THE THREATENED IROKOS (MILICIA EXCELSA [WELW.] C.C. BERG) CONSERVATION IN BENIN: A COMBINATION OF GEOSTATISTICS AND ECOLOGICAL NICHE MODELING
Authors:   Laboratoire de Biologie Experimentale et Clinique (LaBEC), Ecole Nationale Superieure des Biosciences et Biotechnologie Appliquees (ENSBBA), Universite Nationale des Sciences, Technologies, Ingenierie et Mathematiques (UNSTIM), BP 14 Dassa-Zoume, Benin., Boris Cachon Fresnel , Seblodo Judes Charlemagne Gbemavo Dossou ,   Unite de Biostatistique et de Modelisation (UBM), Ecole Nationale Superieure des Biosciences et Biotechnologies Appliquees (ENSBBA), Universite Nationale des Sciences, Technologies, Ingenierie et Mathematiques (UNSTIM), BP 14 Dassa-Zoume, Benin.,   Laboratoire de Biomathematiques et dEstimations Forestieres, Faculte des Sciences Agronomiques, Universite dAbomey-Calavi, 04 BP 1525, Cotonou, Benin.
Published: January 2023

Although Iroko (Milicia excelsa) is listed endangered and has a great socioeconomic and cultural importance in Benin, there have been few attempts to definition of sustainable conservation strategies for the species. This study explored the spatial patterns of the species and tested if the species distribution may be affected under future climates forecasts. Moran index was used to measure the spatial autocorrelation of the abundance of Iroko. For the niche modeling, records of the species were added to bioclimatic variables (current and future conditions) and soil layers in the maximum entropy algorithm. Results showed overall a spatial dependency between Iroko population according to the density (P < 0.001). The population density seems similar between 0 and 3 km but differ from 3 to 150 km. A slight increase was noted from the present-day distribution to the future forecasts (4.71 % and 6.95 % respectively following the scenarios RCP4.5 and RCP8.5). Urgent conservation actions are needed to safeguard the remnant populations of Iroko in Benin.
VATS VERSUS LAPAROSCOPY TRAUMATIC DIAPHRAGMATIC INJURY REPAIR
Authors:   Essex Cardiothoracic Center, Basildon Hospital, Mid and South Essex EssexTrust - United Kingdom., Asfour Ayman , Hussein Khalil Ahmed ,   Kasr Al Aini, Faculty of Medicine, Cairo University - Egypt., Soliman Mostafa ,   Kasr Al Aini, Faculty of Medicine, Cairo University - Egypt.
Published: January 2023

Introduction:Diaphragmatic injury is usually missed in case of trauma patient, clinical picture is usually masked by other abdominal or thoracic injuries. CXR (chest X ray), abdominal ultrasound have a high rate of missing. High index of suspicion is required to diagnose diaphragmatic injury. Discussion:Comparison between 20 cases of traumatic diaphragmatic injury. Surgery is the only treatment. Different approaches are used, taking advantage of the wide spread practice of minimal invasive surgeryVATS (Video assisted thoracoscopic surgey) and laparoscopy. Overlooked injuries are usually on the right side and after blunt trauma in these cases open surgery is favoured.Prolene stitch repair (primary repair) was the main modality of repair, mesh repair was used in larger tears with poor quality tissues .Quality of life improves remarkably after repair with most patients discharged from hospital within few days. Conclusion:VATS and Laparoscopy show efficiency in both diagnosis and treatment of diaphragmatic injuries. Conversion to open surgery may be needed in case of severe visceral injuries.Combined approach needs good communication between thoracic and general surgeonsOutcome is usually favourable with competent long term repair. Uunfavourable outcome is associated with multiple visceral organ injury and critical pre operative status.