bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of early application of heparin on coronary blood flow during primary percutaneous coronary intervention
Authors: Shi Shutian , Zhen Lei , Wang Mei , Wang Chunmei , Ai Hui , Que Bin , Nie Shaoping
Published: September 2023

Purpose: To investigate the efficacy and safety of unfractionated heparin (UFH) anticoagulant administered upstream in the ambulance or emergency room during primary percutaneous coronary intervention (pPCI) for patients with acute ST-segment elevation myocardial infarction (STEMI).Methods: The study included STEMI patients who received either early UFH subcutaneously (SC) (n = 163) or intraoperative UFH (SC) during pPCI (n = 476) between January 2017 to August 2018. Baseline characteristics, infarct-related artery (IRA) status, and procedural characteristics were analyzed. The primary endpoint was thrombolysis in myocardial infarction (TIMI) flow grade 2 - 3 before intervention. The secondary endpoints were time from first medical contact to guidewire passage, postoperative TIMI 3 flow grade, acute stent thrombosis, and in-hospital bleeding events.Results: Baseline characteristics were similar between the groups, with no significant difference in IRA location. Both groups underwent coronary angiography, with most patients receiving pPCI. The primary endpoint occurred in 18.1 % of patients in intraoperative UFH group and 27.6 % in the early UFH group, with a significant difference between the groups (p < 0.05). There was no significant difference in postoperative TIMI 3 flow grade or acute stent thrombosis, but bleeding events (BARC 2-5) were similar between groups (1.1 % in intraoperative group and 1.8 % in early UFH group, p > 0.05)Conclusion: Early upstream administration of UFH anticoagulation in STEMI patients improves coronary artery potency before pPCI, and early use of fixed-dose UFH is safe and does not increase major bleeding complications.
Efficacy of the combination of valsartan and hydrochlorothiazide in the treatment of hypertensive heart disease
Authors: Zhou Xin , Chu Yuefeng
Published: September 2023

Purpose: To investigate the effectiveness of the combination of valsartan and hydrochlorothiazide in managing hypertensive heart disease.Methods: From August 2020 to October 2022, the case data of 120 patients in Lu’an Hospital of Anhui Medical University, Lu’an, China were analyzed retrospectively. Based on the different treatment options, 54 patients with hypertensive heart disease who received valsartan alone (80 mg, once daily) for 3 months were placed in control group (CG), while 66 patients who received valsartan combined with Systolic blood pressure (SBP), therapeutic effect, diastolic blood pressure (DBP), and incidence of adverse effects were also recorded for CG and SG.Results: In the SG, there were significant reductions in SBP, DBP, LVMI and LVPWT compared to CG, while EF showed significant increase after treatment (p < 0.05). In both groups, SBP, DBP, LVMI and LVPWT decreased significantly after treatment compared to pre-treatment values, but EF however showed a significant increase (p < 0.05). In the SG, there was a significant increase (p < 0.05) in the total effective rate compared to CG and there was also a significant reduction (p < 0.05) in the total incidence of adverse effects compared to CG.Conclusion: Valsartan combined with hydrochlorothiazide is more effective in treating patients with hypertensive heart disease than valsartan monotherapy alone. However, the combination treatment should be subjected to further clinical trials prior to its introduction into clinical practice.
Meta-analysis of the effectiveness of Euodia rutaecarpa Benth acupressure and Wendan decoction in the treatment of vertigo
Authors: Wu Tianying , Zheng Qiang , Niu Shuxian
Published: September 2023

Purpose: To systematically assess the efficacy and safety of combining Euodia rutaecarpa Benth acupressure with Wendan decoction for the treatment of vertigo, thereby establishing a theoretical framework for informed clinical practice.Methods: Computer-based search was conducted in PubMed, Embase, Scopus, Web of Science, and Cochrane databases to identify randomized controlled literature pertaining to efficacy and safety of Euodia rutaecarpa Benth acupressure in combination with Wendan decoction for management of vertigo. The experimental group received an intervention of Euodia rutaecarpa Benth acupressure combined with Wendan decoction. Articles that met set inclusion and exclusion criteria were screened and evaluated for quality based on Cochrane Quality Rating Scale. Baseline data, intervention data and outcome indicators of included studies were also extracted. Meta-analysis was performed using RevMan 5.4 software.Results: The difference in symptom scores between groups was statistically significant (RR = -0.04, 95 % CI (-0.3, 0.23), p = 0.78). Meta-analysis of the outcome indicators showed heterogeneity at p < 0.0001, I2 = 91 %. I2 = 91 > 50 %. There was a statistically significant difference (p < 0.05) between groups in terms of total treatment efficiency (RR = 0.31, 95 % CI (-0.25, 0.88), p = 0.28). Heterogeneity of vertigo degree score showed p < 0.0001, I2 = 98 %. I2 = 98 % > 50 %, SMD = 2.34, 95 % CI (0.69, 3.99), p = 0.53.Conclusion: The combination of clinical Euodia rutaecarpa Upright acupressure and Wendan decoction demonstrates significant clinical effectiveness in treating vertigo as evidenced by improvement of all indicators. Moreover, this treatment approach exhibits a high level of safety.
Uso de Google Trends como herramienta infodemiológica en el campo de la Salud Laboral
Authors: Palomo Llinares Ruben , Sanchez Tormo Julia
Published: September 2023

En la actualidad, la obtención de datos basados en el uso de la Web se está convirtiendo en una de las principales fuentes de información para el análisis, la detección y el pronóstico de enfermedades. Por tanto, el enfoque infodemiológico puede brindar grandes oportunidades para la extracción de datos e información de salud generados directamente por los usuarios, ayudando a conseguir una mejor predicción del comportamiento humano en todos los ámbitos de la salud…
A Bioinformatics Approach to Male Infertility, MicroRNAs, and Targeted Genes
Authors: KAYA Murat
Published: September 2023

Purpose: Infertility affects nearly 12% of couples worldwide, with a male factor being the primary or contributory reason in around 50% of cases. MiRNAs are essential post-transcriptional regulators in the spermatogenesis process, and dysregulated miRNAs have been shown to have harmful effects on male fertility. However, it is unclear which miRNAs are associated with infertility-related genes. The aim of this study is, to utilize various bioinformatics approaches, to identify miRNAs that may have a role in the regulation of infertility-related genes.

Materials and Methods: The study first selected genes associated with infertility from the Male Infertility Knowledge Base (MIK) database. Pathway analysis of the defined genes, PPI interaction, and hub proteins related to these genes were revealed by the Elsevier pathway collection database and Enrichr tool. Following that, miRNAs that can influence infertility-related genes were determined, and the influence of the miRNA-target gene connection on male infertility was established bioinformatically using various in silico tools like miRPathDB 2.0 tool, StarmiR, and miRNet.

Results: Male infertility associated 21genes were selected from the MIK database and 15 miRNAs were identified that are most likely to regulate these genes bioinformatically. 10 hub proteins related to defined male infertility genes were analyzed.

Conclusion: Our bioinformatic study results indicate that miR-34a-5p dysregulation may contribute to infertility through CREM, LAMP3, AGBL5, FOXM1 genes and and also miR-335-5p may cause infertility via the CFAP65, CFTR, and GAPDHS genes.
AWARENESS AND PREVALENCE OF TRADITIONAL AND COMPLEMENTARY MEDICINE IN PATIENTS, APPLICATION TO ORTHOPEDICS AND TRAUMATOLOGY OUTPATİENT CLINIC
Authors: HOROZ Levent , ÇAKMAK Mehmet Fevzi
Published: September 2023

Introduction: This study aimed to determine the awareness of complementary and alternative medicine practices and the frequency of treatment usage among patients admitted to an orthopedic outpatient clinic. Method: Patients who presented to the orthopedics outpatient clinic of the University Hospital between November 15 and December 30, 2022, were invited to participate in this study. A questionnaire containing 16 questions about eight different traditional and complementary approaches, designed to determine patients' knowledge of and attitudes toward each of these practices, was administered by the responsible physician through face-to-face interviews. The questionnaires were administered to 637 volunteers. The results were recorded, and statistical analysis was applied. Results: The volunteers were % 54.7 male and 45.3.2% female participants. The mean age of the participants was 41.52 ± 16,349. It was determined that gender (p=0.3) and education level (p=0.207) did not affect awareness of traditional treatment. However, it was determined that the settlement area affected the awareness of traditional treatment (p< 0.05). It has been revealed that the age group with the highest awareness is young adults between 20-30. Conclusions: The popularity of traditional treatment methods and applications is increasing daily. Despite this, it was observed that awareness was low among patients who applied to the orthopedics outpatient clinic. There is a need to train professional health service providers so that the public can access such treatment approaches and increase social awareness.
基于气候政策覆盖度看地方政府低碳策略
Authors: Lin Jiaying , Qiu Shiyong , Liu Siyi , Liu Daizong
Published: September 2023

本研究旨在填补城市气候政策评估的空白，为中国城市制定气候行动规划和政策提供参考和借鉴。通过借鉴“城市清洁能源计分卡”的框架，研究梳理了12个样本城市的气候政策，并提出了评估国内外城市气候政策覆盖度的指标体系，包括城市层面的倡议、建筑政策、交通政策、能源和水务公用事业、地方政府运营、绿色金融和废弃物管理等7个领域、57项指标。研究发现政策覆盖度较高的城市具有明确的分领域目标和规划，并能形成协同作用。金融手段和人才队伍建设对城市的低碳发展至关重要，有待进一步提升。城市的低碳策略选择受多个因素影响，但整体上城市比国家更有气候雄心。本研究为促进国内外城市间的相互学习以推动低碳转型提供了重要参考。
Recurrent Pregnancy Loss, Ayurveda - A Ray of Hope
Authors: Ashok Lamani  , G. Ramadevi
Published: September 2023

Motherhood is a dream of every woman. The fulfilment of this dream is a big challenge to clinicians and the couple, as many couple face problems in conception. The continuation of pregnancy after conception is also a challenge in present era. Pregnancy loss is often associated with physical, psychological and social deprivement. Couple becomes more depressive when there is recurrent pregnancy loss complicated with metabolic disorders. Here Ayurveda plays a very important role to combat with such ailments.
Methods: The patient was treated with Shodhana Karma followed by oral medications for 3 months.
Results: The patient conceived after 3 months of oral medication. She was under regular antenatal care and Ayurveda management throughout her gestational period. Pregnancy was uneventful till 35weeks 3days and delivered vaginally a healthy female baby of 2550grams.
Efficacy of Deepana-Pachana, Swedana and Shamana Chikitsa in Juvenile Idiopathic Arthritis (JIA)
Authors: Bhatt Lalit Mohan  , Agrawal Neeraj  , Chandravanshi Lowkesh  , Dushyant
Published: September 2023

Juvenile Idiopathic Arthritis (JIA) is a type of most common chronic inflammatory rheumatic disease with very little clarity about etiology and pathology. Main clinical findings: A 16-year-old adolescent female girl with the complaint of pain and swelling in knee joint bilaterally, difficulty in walking, restricted movement and pain in wrist, ankle and interphalangeal joints, morning stiffens in hand and wrist joints. Diagnosis: This case of Juvenile Polyarticular (RF positive) arthritis was diagnosed as Amavata (symptoms suggest pravridhavastha). Interventions: Treatment given for 3 months in a duration dependent pattern. Deepana, Pachana followed by Snehan, Rechana and Baluka sweda, Upnah was done along with oral medications. Outcome:  Patient felt relief in pain, swelling of joints reduced, restriction of joint movement was reduced, Lakshana of Ama like Anorexia, Fatigue, Heaviness and Laziness were also relieved. Conclusion: This paper is an attempt to explore effectiveness of Ayurvedic treatment in case of JIA.
Role of Abhrakadi Yogam in the Management of Type II Diabetes Mellitus
Authors: Krishna G.S  , L. Mahadevan  , Kasthuri Nair.A  , Arun Pratap
Published: September 2023

Diabetes Mellitus is a metabolic disorder predominantly affecting carbohydrate metabolism, characterized by high blood sugar levels (hyperglycemia). It occurs either due to insufficient secretion of insulin by the pancreas or when cells don’t respond to the insulin being produced. Type 2 diabetes is the most prevalent form of diabetes accounting for about 90% of the total diabetic population. Maintaining a healthy diet, engaging in regular physical activity, and prioritizing mental well-being are the key factors to maintaining proper bodily metabolism. Sedentary lifestyles and hereditary factors primarily contribute to the development of type 2 diabetes by causing metabolic imbalances. In Ayurveda, descriptions of Prameha particularly Madhumeha show close similarities with type 2 diabetes mellitus. According to Ayurveda, all diseases stem from improper functioning of Agni, often interpreted as metabolic errors seen in diabetes. Madhumeha is a condition characterized by vitiation of Tridosha and 10 Dushya. Correcting the Agni and restoring the normalcy of Dosha and Dhatu is necessary for managing Diabetes. Here a literary review is done in evaluating the potential mode of action of Abhrakadi Yogam mentioned in Yogaratnakara, Prameha Chikitsa having Deepana, Srotosodhana, Vatanulomana, Rasayana, Pramehaghna properties in the management of Type 2 diabetes mellitus.
Pilot Survey of the Diagnosis and Management of Heart Failure in Primary Care: A Singaporean Perspective
Authors: Soon SR , Yong R , Chew ZH , Lee JMJ , Lam CSP
Published: September 2023

Introduction: The diagnosis and management of congestive heart failure at the primary care level is difficult. Despite advances in medical therapy, namely angiotensin-converting enzyme inhibitors and β-blockers, congestive heart failure remains a common cause of hospital visits. The extent to which these advances have been implemented in primary care is uncertain. We therefore sought to assess current practice patterns of primary care physicians and identify obstacles to optimal diagnosis and management of congestive heart failure in Singapore.
Materials and Methods: Telephone interviews of 100 primary care physicians using structured questionnaires.
Results: Primary care physicians diagnose congestive heart failure based on the presence of breathlessness (92.5%), lung crackles (52.5%), peripheral oedema (55.0%) and findings on chest radiography (76.8%). Only 1 in 3 mentioned raised jugular venous pressure as a useful diagnostic sign. Echocardiography was not commonly obtained (5%), mainly due to inaccessibility. While many (47.5%) were aware of the importance of angiotensin-converting enzyme inhibitors, few (16.2%) knew of the impact of β-blockers on morbidity and mortality. Instead, diuretics were thought to be most important for prolonging survival in congestive heart failure (47.5%). The main obstacle to widespread angiotensin-converting enzyme inhibitors usage was dry cough. Patient compliance (57.5%) and cost (82.5%) were the main obstacles to optimising care.

Conclusions: Local primary care physicians diagnose congestive heart failure using non-specific symptoms and signs. Obstacles to optimal congestive heart failure management were identified. We hope our results will lead to strategies to improve patient care.
Integrated Hydroxyapatite Implant and Non-integrated Implants in Enucleated Asian Patients
Authors: Chuah CT , Chee SP , Fong KS , Por YM , Choo CT , Luu C , Seah LL
Published: September 2023

Introduction: This study compares the outcome and complications of integrated hydroxyapatite implant and non-integrated orbital implants following enucleation in Asian patients.

Materials and Methods: This is a retrospective study of enucleated patients with coralline hydroxyapatite implants versus non-integrated implants (acrylic, glass and silicone) at the Singapore National Eye Centre from January 1991 to December 2000. The outcomes measured were implant migration, extrusion, socket infection, conjunctival dehiscence and implant exposure. Statistical analysis was done using the 2-sample t-test.

Results: Twenty-one patients had the hydroxyapatite implant and 38 non-integrated implants (27 acrylic, 9 glass and 2 silicone). The mean duration of follow-up was 2.7 years and 4 years for the hydroxyapatite implant and non-integrated implants respectively. Three patients with pre-existing severe socket contracture before enucleation surgeries were excluded from the study. Four cases of implant migration, 4 cases of implant extrusion and 3 cases of socket infection were encountered; all were sockets fitted with non-integrated implants. There was a higher rate of conjunctival dehiscence for sockets with hydroxyapatite implants (6 out of 21) compared to sockets with non-integrated implants (3 out of 35). This was statistically significant (P = 0.048).

Conclusion: Implant complications of migration, extrusion and socket infection were found in non-integrated implants and none in coralline hydroxyapatite implants, which had a significantly higher rate of conjunctival dehiscence. Most of these were easily managed with only a small number progressing to implant exposure.
Contact Lens Microbial Keratitis and Prior Topical Steroid Use: A Disaster in the Making?
Authors: Wang JC , Su D , Lim L
Published: September 2023

Introduction: To review the best-corrected visual acuity, ulcer size, microbiological profile and morbidity of contact lens-related microbial keratitis with and without prior topical steroid use.

Materials and Methods: Retrospective case review of admitted cases of contact lens-related microbial keratitis in a tertiary hospital. Data pertaining to demographics, pre-admission treatment with or without topical steroids, ulcer size, duration of admission, Gram stain and culture results as well as the final best-corrected visual acuity were recorded. Patients are classified into 3 groups: Group 1 received no treatment prior to presentation, Group 2 received topical antibiotics only from their general practitioners and Group 3 prescribed both topical antibiotics and steroids.

Results: Forty-six cases were enrolled in the study, 41.3% had prior topical steroids (all dexamethasone) in combination with antibiotics. None of them had topical steroids alone. Large ulcers were associated with steroid use, odds ratio = 7.74 [95% confidence interval (CI), 1.18-50.56] and positivity of Gram stains odds ratio = 7.74 [95% CI, 1.18-50.56] whereas loss of more than 2 Snellen lines was associated with Pseudomonas aeruginosa infection, odds ratios of 21.70 [95% CI,2.09-225.03] and presence of central ulcer, 13.51 [95% CI, 2.33-78.3]. Prior topical steroid use was associated with longer duration of symptoms prior to admission but not duration of stay or surgical intervention.

Conclusion: Patients with prior topical combined antibiotics-steroids present slightly later and with larger ulcers. However, the duration of stay, final visual acuity, treatment failure and complication rates were not statistically different from the non-treated group. This might be due to 1) early presentation and therefore early treatment of contact lens-related microbial keratitis and 2) the short duration of use of combined antibiotic-steroid eye drops.
Behcet’s Disease: Experience in a Tertiary Rheumatology Centre in Singapore and a Review of the Literature
Authors: Cheng YK , Thong BY , Chng HH
Published: September 2023

Introduction: The only reported study on Behcet’s disease (BD) in Singapore found that only 15% of 34 BD patients managed at a tertiary dermatology centre had arthritis and 6% had eye complications with no other systemic manifestations. The aim of our study was to characterise the clinical manifestations and outcome of patients with BD at a tertiary rheumatology centre in Singapore.

Materials and Methods: The International Study Group (ISG) and the O’Duffy (OD) criteria were used. The demographics, manifestations and outcome of our patients with BD were recorded.

Results: Thirty-seven patients were included in our study. Twenty-three (62.2%) satisfied both ISG and OD criteria. Fourteen (37.8%) did not fulfil the ISG criteria but fulfilled the OD criteria and of these 6 were the incomplete form and 8 the complete form. The male to female ratio was 1:1.1. The mean age of onset of disease was 32.7 years (range, 15 to 58 years). The commonest presentations were recurrent oral ulcers (37, 100%), genital ulcers (24, 64.9%), joint (21, 56.8%) and cutaneous manifestations (18, 48.6%). The most common systemic manifestations were arthritis (16, 43.2%), gastrointestinal manifestations (15, 40.5%) and uveitis (13, 35.1%). There were 2 cases of Neuro Behcet’s and 2 cases of venous thrombosis. Visual impairment from uveitis was the commonest cause of morbidity. There were no deaths in our series of BD.

Conclusion: BD is a relatively rare rheumatologic condition in Singapore. However, because its systemic complications are not rare, early diagnosis and prompt treatment are essential.
Posters
Authors: Congreso Argentino de Reumatología Comité Científico
Published: September 2023

Posters presentados durante el 56° Congreso Argentino de Reumatología del 4 al 7 de octubre de 2023, en Centro de Convenciones Salta, Ciudad de Salta, Argentina.
Avaliação remota da maturação em soja por imagens de drones
Authors:   , Donato Lucas Titonelli Ferreira
Published: September 2023

Nos programas de melhoramento de soja, uma das tarefas executadas em campo é estimação do número de dias do plantio até a maturação, no qual define-se a recomendação de uma determinada cultivar por meio dos grupos de maturação. Essa atividade demanda uma elevada mão de obra e visitas frequentes aos experimentos avaliados. Além de ser uma atividade dispendiosa, a fenotipagem humana possui uma chance considerável de erro na classificação das parcelas. Com o objetivo de melhorar a execução dessa função, este estudo buscou analisar e validar uma metodologia para avaliação remota da maturação em soja com uso de câmera RGB acopladas ao drones de baixo custo. Através de índices vegetativos, ambientes modelos estatísticos e extração de pixels nas parcelas, foi possível verificar quais combinações apresentam maior correlação comparadas as realizadas por profissionais em campo. Coletou-se dados em solo de 90 parcelas em 3 ambientes para realizar comparação com o estimado pela metodologia proposta. A combinação dos índices GLI (greeness leaf index) e NGRDI (normalized red green difference index) com o modelo de regressão local não paramétrica, LOESS (Locally estimated scatterplot smoothing), e extração da mediana dos pixels, revelou uma forte correlação de Pearson quando comparados à maturação aferida em campo (r = 0,84 - 0,94 para GLI. r = 0,81 - 0,93 para NGRDI). Outro parâmetro que contribuiu para validação da metodologia foi o RMSE (root-mean-square error), que apresentou valores consideravelmente baixos (RMSE GLI = 1.24 - 1.66, RMSE NGRDI = 1.30 - 2.04). Também foi possível identificar que um dos ambientes gerou menores correlações, sendo possível associar esse menor desempenho à presença de plantas invasoras e falhas de germinação nas parcelas analisadas. Dessa forma, a metodologia se mostrou confiável, com uma boa acurácia e alta precisão, porém é necessário se atentar as condições do ambiente a nível de parcela experimental. Palavras-chave: UAV. Glycine max. Sensoriamento remoto aéreo. Fenotipagem de alto rendimento. Melhoramento vegetal
The Influence of Firm Size, Capital Structure and Profitability on Firm Value in Food and Beverage Sub-Sector Manufacturing Companies Listed on the Indonesia Stock Exchange
Authors: Nurhandari R.A. Lutfiah , Fatimah Fatimah , Choiriyah Choiriyah
Published: September 2023

This study aims to determine the effect of company size, capital structure and profitability on company value in food and beverage manufacturing companies listed on the Indonesia Stock Exchange (IDX). The samples used were 14 from 27 populations using a purposive sampling technique with a research period of 8 years, 2015-2022. The analysis technique used is multiple linear regression. The study results show that company size, capital structure and profitability significantly affect firm value in food and beverage companies on the Indonesia Stock Exchange. Partially, capital structure impacts a firm value; profitability significantly affects firm value, while firm size has no significant impact on firm value
Bridging Policy and Practice: An In-depth Exploration of How the DepEd Child Protection Policy Influences Teacher Discipline Strategies
Authors: Mag-atas Johjen D. , Carmona Beverly M.
Published: September 2023

This paper employed a qualitative ethnographic approach aimed at capturing the nuanced experiences of elementary and secondary school teachers in Marikina City in their natural classroom settings and sought to unravel the intricate web of relationships between policy and practice. The DepEd Child Protection Policy, a foundational document in the Philippine educational system, provides educators with direction in the teaching-learning process. It is important to pay great attention to the intricate and dynamic process of comprehending how this policy is implemented in actual classroom settings. For this reason, the study attempted to determine the significance of how the DepEd Child Protection Policy influences teacher discipline strategies by using the emic perspective of ethnographic research. The proponents arranged a focus group discussion in which thirteen teacher-informants took part. It was revealed in the study that the DepEd Child Protection Policy is essential for protecting children from abuse, but concerns about its strictness have led to a potential impact on teachers. Teachers face challenges in implementing the policy, such as fear of consequences and balancing classroom autonomy and parental involvement. Clear communication, consistent rule implementation, and strong relationships with students, parents, and guardians are crucial for creating a safe and inclusive learning environment. Lastly, it suggested expanding the study's sample size in order to get additional information from primary and secondary teachers as well as to incorporate the viewpoints of students and parents in order to validate the instructors' answers.
The Impact of Taxation in Combating Corruption and Promoting Sustainable Development Goals in Nigeria
Authors: T Omotehinse , E. T Esenohor , G. A Okoh
Published: September 2023

The role of taxes in combating corruption is studied, as is their potential contribution to Nigeria's progress towards the SDGs. Corruption has become a major roadblock to the country's progress, preventing both economic growth and social progress. This essay delves into the interplay between taxation, corruption, and long-term progress and stresses the value of an effective tax system in promoting openness, accountability, and economic development in Nigeria. This research builds on previous studies in the field to provide new insights into how the country's tax system might be improved to reduce corruption and boost sustainable growth. According to the data, taxes still play a critical role in setting the course for a brighter future. Nigeria can pave the way for economic prosperity, fairness, and societal progress by acknowledging taxes as a tool to combat corruption and promote sustainable development. This can contribute to a more just and stable global order.
Document verification system at college level using Blockchain
Authors: Sakshi Asode  , Tejaswini Dumbare  , Achal Ghadge  , Samiksha Thombare
Published: September 2023

Blockchain technology promises to be hugely trending and empowering in education domain computing applications. The digital is becoming an integral part of modern life. So as the use of the digital world increases there are more chances of decrease is the security level. So more the use of digitization more the frauds and less the security. In some cases of personal data, leakage has brought back into the focus the security issues with the different identity sharing mechanisms. A customer is expected to provide his identity for authentication by different agencies. So the document verification process deals with the identification of the user. And in turn, provides the required security. The document verification procedures which are used by the colleges are completely dependent on the encryption. This system can be efficient by using Blockchain technology, which has the potential to automate a lot of manual processes and it is also resistant to hacks of any sort. The immutable blockchain block and its distributed ledger is the perfect complement to the process of document verification. With the addition of smart contacts, fraud detection can be automated..
The Creative Edge
Authors: Fletcher Mary C.
Published: September 2023

Transform your library from a place of information into a place for inspiration. Library facilitators of art-based creativity sessions will learn how to choose materials and art experiences appropriate for young people from toddlers to teens and for intergenerational groups. In the modern world, innovative and creative individuals have a distinct advantage: the creative edge. The Creative Edge explains how you can design and conduct art-based creativity programming in your library. Written by a library creativity specialist, this book is the result of the author's many years of experience facilitating art groups for all ages. Her programs have achieved national recognition and will serve as a guide for others to establish art-based creativity sessions. In this book, she incorporates research that documents the importance of creativity as an essential component of childhood development and connects it to library learning goals, including literacy. Creativity research can be applied in libraries and at other public institutions to develop programs that will meet the needs of the next generation. The book includes many practical elements, such as lists for recommended art materials, step-by-step instructions on setup and procedures, and ideas inspired by picture book illustrations that connect to story time themes. The Creative Edge teaches readers how to provide programs that promote child-led exploration, experiential learning, innovative thought, and creative confidence.

Offers a guide for creativity programming for librarians, teachers, program coordinators, and college students

Teaches how to facilitate open-ended creativity programs for children of all ages and caregivers

Describes how to design story time art groups linking art and literacy inspired by picture book illustrations
On Making a Limited Edition Jewelry Pin in Honor of the Tenth Anniversary of the Academy of Watercolor and Fine Arts of Sergey Andriaka
Authors: Kolesnikov D. A. , Eremenko V. A.
Published: September 2023

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Landscape in Leningrad Porcelain Art of the “Thaw” Period
Authors: Shik I. A.
Published: September 2023

Landscape became one of the dominant genres of Leningrad porcelain art of the “Thaw” era, reflecting the peculiarities of Soviet culture in the second half of the 1950s – 1960s with its characteristic desire to explore new spaces, changes in the appearance of cities, as well as mass construction. Thus, it is not coincidental that such well-known Leningrad porcelain artists as Vladimir Gorodetsky, Nina Slavina, Antonina Semenova, Larisa Grigoryeva, Tamara Bezpalova-Mikhaleva, Lidia Lebedinskaya among others created landscape compositions. When interpreting landscapes in a “modern style”, they often strived to convey the “overall impression of the depicted” through the use of iconic motifs, allowing the viewer’s imagination to independently complete the image. Landscapes could be of a stylized, graphic nature or, on the contrary, could be characterized by a picturesque freeness. In some cases, landscape came closer to abstraction, symbolically conveying the image of a particular season. Artists often used a tiered type of composition in their interpretation of urban and suburban landscapes, combining the conciseness of a linear drawing and bright, expressive color, or, by contrast, making it almost monochrome. The image of Leningrad was transformed in the porcelain art of the “Thaw” period in accordance with the principles of the “modern style”: strict classical style was combined with modernist generalization and stylization. The theme of new construction was attractive for the artists as well: they depicted graphic images of houses under construction, cranes, and industrial structures. Landscape compositions were distinguished by a harmonious combination of shape and design. Artists often sought to emphasize the features of the form, arranging the composition accordingly while placing special visual accents. Porcelain artists often left most of the surface of objects unpainted, accentuating the beauty and sonorous whiteness of porcelain as a material or using it as an element of an artistic image. At the same time, artists actively applied the technique of colored overglaze, often supplemented by line painting or cleaning, and also experimented with unpredictable effects from the spreading of paints, similar to experiments with colored glazes in “Thaw” ceramics. The coloristic solution of the paintwork was extremely laconic: usually no more than two or three colors were used.
Association of health literacy and physical activity with physical fitness level among adults
Authors: Jayakumar Ramya , Tanaji Methre Seema , Namdeorao Patil Ashwini
Published: September 2023

Introduction and Aim: ‘Health is wealth’ is the best quote heard but the importance of it is realized only when health is lost. This study aims to assess the knowledge of health information, physical activity level among the adults and correlate this with their physical fitness.
 
Methods: Healthy adults were recruited from the general population through simple random sampling. Physical activity, health literacy, muscle strength, endurance and flexibility were assessed using International Physical Activity Questionnaire (IPAQ), Health Literacy Survey European Questionnaire 16, hand grip test, curl up test, sit and reach test respectively. Data analysis was performed using Primer of Biostatistics (Version 7) statistical software.
 
Results: A total of 51 participants (36 females) with an average age of 34 years and BMI of 24.2 kg/m2 were recruited in the study. Health literacy (HL) score was found to be inadequate in 15% and limited in 37% of the studied population. Majority (62%) had low levels of physical activity. We found a strong association of health literacy, with physical activity and muscle strength, muscle endurance, flexibility and physical fitness index (p = 0.000 for all).
 
Conclusion:  The health literacy was good, though the physical activity scores indicated more inactive people. Majority had normal muscle strength and average to above average level of flexibility, but muscle endurance was greatly affected owing to an unacceptable physical fitness index. The study demonstrates significant association between health literacy, physical activity, and physical fitness level among adults. Adequate health literacy is necessary to comprehend and utilize health information.
In vitro anticancer efficacy of Cyperus rotundus (L.) on breast adenocarcinoma cells via the induction of DNA fragmentation and apoptosis
Authors: Nidugala Hema , Prabhu Ashwini , Avadhani Ramakrishna , B. Ravishankar
Published: September 2023

Introduction and Aim: Cyperus rotundus (L.), commonly known as nutgrass, has been in use in Indian medicine traditional system against several ailments. This investigation was performed to assess the in vitro antineoplastic activity of extracts prepared from water and ethanol with C. rotundus rhizomes.
 
Materials and Methods: Toxic effects induced by the C. rotundus extracts on MCF-7 breast adenocarcinoma cells was evaluated using Sulphorhodamine- B (SRB) Assay, Trypan blue assay, Hoechst nuclear staining assay, Acridine Orange-Ethidium bromide (AO-EB) differential fluorescence staining assay and DNA fragmentation assays.
 
Results: The results of SRB assay indicated the IC50 value of aqueous extract as 510.887 µg/mL and that of ethanol extract as 122.98 µg/mL. Trypan blue assay also indicated the similar results, wherein ethanol extract exerted higher cytotoxicity compared to the aqueous extract. MCF-7 cells treated with aqueous and ethanol extracts of C. rotundus rhizomes were exposed to Hoechst staining and AO-EB nuclear staining assays, wherein and ethanol extract induced clear apoptotic bodies in the tested cells. Further, the cells were treated with the ethanol extract and DNA fragmentation was confirmed by DNA ladder assay. MCF-7 cells administered with ethanol extract were subjected to DNA fragmentation assay for assessing the apoptosis induction nature of the extract.
 
Conclusion: Results from our study indicate a promising approach into the possibility of developing C. rotundus ethanol extract into an effective anticancer moiety after appropriate pre-clinical and clinical validations.
Surface roughness and bacterial adhesion on composite materials: an in vitro comparative evaluation
Authors: Sengupta Ishani , Ballal Mamatha , Mahesh Saahithya , Acharya Shashi Rashmi
Published: September 2023

Introduction and Aim: Despite being popular, composite materials frequently degrade, and cause secondary caries in the oral cavity. Studies suggest that surface characteristics, particularly surface roughness, can impact the functionality, durability, and biofilm formation of these materials. This study was carried out to evaluate and compare the surface roughness of nano-ceramic restorative and bulk-fill flowable composite materials and their bacterial adhesion properties using Streptococcus mutans.
 
Materials and Methods: 16 disks of each composite type, Ceram x SphereTEC one universal nano-ceramic restorative material and SDR flow plus bulk-fill flowable material were fabricated and grouped as A and B, respectively. 2D surface roughness of the samples were recorded using Contact Profilometer. For bacterial adhesion test, samples were incubated in a culture of S. mutans overnight. Adhered bacteria were determined by spread plate technique, colonies were enumerated and reported as CFU/mL. Kolmogorov-Smirnov and Shapiro-Wilk tests helped determine normality distribution of surface roughness, and statistical significance was analysed using Independent-samples t test. Bacterial adhesion was analysed using Mann-Whitney U test.
 
Results: Surface roughness values were found to be normally distributed, and the difference between the two groups was noted to be statistically significant (p<0.05). However, there was no statistical difference between bacterial adhesion amongst the two materials (p>0.05).
 
Conclusion: Surface roughness value of the nano-ceramic restorative material was lower than that of bulk-fill flowable resin material albeit, the two composites did not show a significant difference in terms of bacterial adherence.
Decision tree analysis for the management of vesiculobullous lesions
Authors: K. V. Swathi , G. Maragathavalli
Published: September 2023

A mucocutaneous condition known as a vesiculobullous lesion is characterized by the presence of fluid-filled vesicles and bullae. Bullae and vesicles typically have different sizes. Bullae have a diameter greater than 5–10 mm, whereas vesicles have a diameter of less than 5–10 mm. Infectious etiologies such herpes simplex, varicella zoster infection, hand, foot, and mouth disease, herpangina, and measles can cause vesiculobullous lesions. Additionally, immunobullous conditions including pemphigus vulgaris, pemphigoid, dermatitis herpetiformis, linear IgA disease, or inherited conditions like epidermolysis bullosa may be to blame. The management of common vesiculobullous disorders is reviewed using a decision tree analysis based on etiopathogenesis, clinical characteristics, and diagnostic criteria. A decision tree has been formulated based on predominantly vesicular and predominantly bullous lesions with specific lesions in each category based on recent scientific evidence. This decision tree will guide the clinicians for effective management of the vesiculobullous lesions in the dental office. The timely recognition and management of these lesions is very essential as they can compromise the quality of life due to their chronicity and frequent recurrence in nature.
Genetic mutation rs972283 of the KLF14 gene and the incidence of gastric cancer
Authors: Bresam Sabah , Majid Abd Ulameer Alhumairi Rasha , M. Hade Istikrar , Abdullah Laftaah Al-Rubaii Bahaa
Published: September 2023

Introduction and Aim: Genetic factors and family gene clustering constitute an important ratio for gastric cancer. Kruppel Like Factor 14 (KLF14) gene has a carcinogenic role and a clear role in metabolic diseases, but how this gene regulates these metabolic traits is still obscure. Previous studies proposed that the accumulation of single nucleotide polymorphisms (SNPs) in KLF14 may be associated with gastric cancer. The current study aimed to investigate whether single nucleotide polymorphisms (SNP) rs972283 in KLF14 is associated with an increased risk of gastric cancer in the Iraqi population.
 
Materials and Methods: The SNP was genotyped using tetra primer ARMS-PCR in 101 (79 men and 22 women) gastric cancer patients who did not receive chemotherapy, and 80 healthy controls (53 men and 27 women). All patient samples were taken from the Baghdad Hospital of Gastroenterology and Hepatology laboratories. Patient records included age, sex, histological type, and H. pylori infection status
 
Results: The KLF14 rs972283 genotype was significantly different between the gastric cancer and control groups. The heterozygous AG genotype and A mutant allele were significantly higher in gastric cancer patients compared to controls (56.4% vs 38.7%, p<0.01 and 61% vs 40.6%, p<0.01, respectively). In contrast, the GG wildtype genotype and G wildtype allele were significantly higher in controls (40% vs 11%, p<0.01 and 59.4% vs 39%, p<0.01, respectively). The AA homozygous mutant genotype also showed a weak correlation with increased gastric cancer risk. These results indicate the A allele is a risk factor while the G allele has a protective effect for gastric cancer.
 
Conclusion: the KLF14 polymorphism rs972283 exhibits a significant association with gastric cancer risk in our Iraqi cohort. The SNP may serve as a useful prognostic marker, pending validation in larger studies.
The diagnostic challenge of gastrointestinal tuberculosis mimicking colon cancer: A case report
Authors: Vityala Yethindra , Turdumambetova Gulnura , Yi Lim Jun , Moidunova Nestan , Usubalieva Elnura , Baitelieva Altynai , Vipin
Published: September 2023

Gastrointestinal tuberculosis (TB) accounts for 3.5% of extrapulmonary TB cases and is associated with active or inactive pulmonary TB in 76% of cases. A 53-year-old lady with no prior history of morbidity visited our hospital's department with weakness, an inability to eat, a 39°C fever, no chills, and night sweats that had been present for about six months. Additionally, a colonoscopy revealed a mamelonated mass of a stenotic character in the ascending colon, along with minor mesenteric adenitis, on computed tomography scans of the abdomen and pelvis. The obtained specimen's histological analysis revealed histiocytes and a few large cells producing granulomas without neoplastic features. The colonic biopsy's Löwenstein-Jensen medium culture revealed development of the Mycobacterium TB complex. After receiving therapy for two months with rifampicin, isoniazid, pyrazinamide, and ethambutol, followed by four months with rifampicin and isoniazid, the patient had significantly improved. The current case serves as an example of the difficulty in diagnosing GI TB. The lack of symptoms and occasionally false-positive imaging results reinforce the necessity for increased clinical suspicion.
Characteristics of structural and functional alterations following traumatic brain injury in neurons and glial cells of the sensorimotor cortex
Authors: Mamytova Elmira , Monolov Nurbek , Turganbaev Bakytbek , Toktomametova Anara , Karbozova Kunduz , Kadyrova Aliya , Abaeva Tamara , Zhanganaeva Mira , Chekirbaeva Nursulu , Altynbekova Zhanara
Published: September 2023

Introduction and Aim: Traumatic brain injury (TBI) is regarded as a significant worldwide health issue and a significant contributor to mortality and disability. The objective of this study was to examine the parameters and nature of the regenerative and destructive processes that occur in the rat cerebral cortex depending on the degree and time of the TBI.
 
Materials and Methods: The experiments were carried out on 24 sexless adult mice weighing 180–220 g. The primary group of mice had severe TBI. To assess the severity of the TBI model, histological data, animal survival rates, and motor and cognitive dysfunctions were examined. Both light and electron microscopy were used to study the animal brains in each group.
 
Results: The areas of injury were filled with blood, and microscopic examination revealed that the foci of contusion had destroyed brain tissue in the form of tissue and blood vessel fragments. Most dystrophic neuronal changes in mice with severe TBI between 1 and 21 days after the injury were acute neuronal swelling, hydropic dystrophy of nerve cells with clear cytoplasmic vacuolization, localized and complete chromatolysis, hyperchromatism, and homogeneous cytoplasm.
 
Conclusion: Brain tissue lesions develop in the early stages of a TBI through rapid necrotic cell death.
Pattern of Haematological and Biochemical Parameters of Dengue Virus Infection in Children
Authors: Shahzeen Shumaila , Mehmood Awan Khalid , Azhar Farooq Muhammad , Sonia Chaudhary Sidra , Ali Mohsin , Ejaz Mehwish
Published: September 2023

Objective: This study was conducted to study pattern of clinical, hematological and biochemical parameters in children with dengue fever. Method: A prospective comparative analysis of 120 suspected febrile children was done at social security teaching hospital in Lahore from September to November 2021. The study participants satisfying the inclusion criteria were registered for further assessment. Clinical findings were logged, hematological and biochemical parameters tests were performed. Results: In this study, there were 56.66 % male participants and 43.33 % female participants. The most common clinical manifestation was fever (100%) followed by vomiting 85.4%, abdominal pain 68.75% and body pain / myalgia in 52.08% cases. Most frequent hematological parameter wasthrombocytopenia (93.75%) followed by leucopenia 70.83% and the elevated levels of liver transaminases were seen in 68.75% subjects. Conclusion: This study focuses on the patterns of laboratory parameters of pediatric dengue viral infections .This might prove helpful for the pediatricians to suspect, diagnose and manage the dengue virus infection.