bluuebunny/crossref_metadata_2025 huggingface dataset:
The value of inflammation-related indicators in chemotherapy efficacy and DFS of triple-negative breast cancer
Authors: Zhu Jie , Cheng Jiale , Ma Yuyuan , Wang Ying , Zou Zhonghua , Wang Wenjie , Shi Haihua , Meng You
Published: October 2024

Background: Neoadjuvant chemotherapy (NAC) is an important measure for improving the prognosis of early operable Triple-negative breast cancer (TNBC) patients. Inflammation-related indicators can predict the outcome of TNBC patients.
Methods: Kaplan-Meier curves were used to evaluate survival. The correlation between these indicators and NAC efficacy was analyzed using t-tests. Models for univariate and multivariate Cox regression analyses were performed to determine the independent risk factors. A nomogram was used for the prediction of one-, two-, and three-year disease-free survival (DFS).
Results: IL-6, PLR, SII, and Ki-67 levels were associated with neoadjuvant efficacy. IL-6, PLR, SII, Ki-67, and lymphocyte count were associated with DFS. The risk score for each TNBC patient was obtained using LASSO regression analysis to construct a prognostic model. In the prognostic model, patients in the high-risk score group showed worse DFS than those in the low-risk group. Risk score and tumor size were independently correlated with outcomes in multivariate Cox regression analysis. A nomogram was constructed using IL-6, PLR, SII, Ki67, and Miller-Payne (MP) scores. Calibration curves demonstrated good consistency between the actual and predictive values of the nomogram.
Conclusion: A prognostic model was established by combining four prognosis-related indicators in TNBC patients who underwent NAC.
Assessment and Quantitative Analysis of Hip Surrounding Muscles in Children with Developmental Dysplasia of the Hip via Magnetic Resonance Imaging
Authors: Duan Lian , Zhou Weizheng , Li Lianyong
Published: October 2024

Background
The muscles that encase the hip serve a crucial role in both joint stability and functional efficacy, and as developmental dysplasia of the hip (DDH) progresses, the surrounding musculature may undergo specific adaptations that reduce joint stability, thereby exacerbating dislocation. Yet, the exact nature of changes in muscle morphology and quality remains inadequately investigated. This study aims to compare magnetic resonance imaging (MRI) evaluations of the iliopsoas and other hip flexor and extensor muscles in children with unilateral DDH before and after treatment.
Methods
Children with unilateral DDH were included in this study and compared to a matched control group. Using T2-weighted MRI sequences, muscle cross-sectional area (CSA) and fat infiltration (FI) were measured for the iliopsoas, sartorius, rectus femoris, tensor fasciae latae, and gluteus maximus. The cross-sectional area ratio (CSAr) was calculated as the CSA of the affected side divided by the CSA of the healthy side, corresponding to the respective sides in normal controls. For long-term follow-up (≥ 5 years), data from DDH children were analyzed, categorized into groups based on treatment. Comparisons of muscle CSAr and FI at the final follow-up were made against preoperative levels.
Results
Preoperative median CSAr values for the iliopsoas, rectus femoris, and gluteus maximus in DDH children were significantly lower than those of the control group (P < 0.001). FI levels were also higher in the DDH group compared to controls. In the closed reduction group, iliopsoas CSAr increased and FI decreased at the final follow-up compared to preoperative measurements. Conversely, in the open reduction group, iliopsoas CSAr and FI decreased. In the Dega osteotomy group, both iliopsoas CSAr and FI decreased, while CSAr for the sartorius, rectus femoris, and gluteus maximus increased, with also reduced FI.
Conclusion
Children with DDH exhibit varying degrees of muscle atrophy and increased fat infiltration compared to their age-matched healthy counterparts. Aside from the iliopsoas, muscle morphology and fat infiltration in DDH children improved post-treatment compared to pre-treatment levels.
Identification of pyroptosis-related biomarkers in venous thromboembolism
Authors: Han Shengbin , Xu Jingzhe , Wang Lianlin , Wang Jiarong , Yu Chenchen , Guan Hongxi , Ding Shun
Published: October 2024

OBJECTIVE
The study was designed with the aim of excavating diagnostic biomarkers of venous thromboembolism (VTE).
METHODS
The GSE19151 and GSE48000 datasets were subjected into this study. The pyroptosis-related genes (PRGs) were sourced from literature1. Differential expression analysis and WGCNA were applied to identify differential genes related with Pyroptosis (DE-PRGs) in VTE. The possible functions of DE-PRGs were defined by means of enrichment analysis. The biomarkers related with pyroptosis in VTE were determined by plotting receiver operating characteristic (ROC) curve. The gene set enrichment analysis (GSEA) was employed to analyze the correlation between biomarkers and pathways. Finally, the quantificational Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) was proceeded to verify the expression level of the biomarkers in VTE.
RESULTS
A number of 52 DE-PRGs were identified by feat of differential expression analysis and WGCNA. A number of five biomarkers (RPL31, RPL34, RPL9, RPS27L and HINT1) were further screened by ROC curves. GSEA pointed to the linkage of five biomarkers to the ribosome proteins and oxidative phosphorylation signaling transduction, which may cause cell pyrodeath and trigger VTE through mitochondrial pathways. qRT-PCR manifested the expression levels of RPL31, RPL9 and HINT1 were all observably higher in VTE samples than in normal samples.
CONCLUSION
A number of five biomarkers, RPL31, RPL34, RPL9, RPS27L and HINT1, were identified as pyroptosis-related biomarkers in VTE, which provided a basis for understanding VTE pathogenesis and new insights into VTE diagnosis and treatment.
WITHDRAWN: The impact of listing companies in emerging markets on the London Stock Exchange on Financial reporting opacity and sustainable growth rate
Authors: Elmaasrawy Hamada , Tawfik Omar , Lamey Ywana
Published: October 2024

Purpose: This paper aims to examine the impact of listing firms listed in emerging markets on the London Stock Exchange (LSE) on both financial reporting opacity (FRO) and the sustainable growth rate, as well as the impact of FRO on the sustainable growth rate (SGR).
Design/methodology/approach; Sample of 77 Egyptian Firms was relied on during the period from 2014 to 2023 with a total of 693 observations. The study uses OLS and 2SLS to test research hypotheses.
Findings: The study found that there is a positive relationship between the listing of Firms in emerging markets on LSE and FRO, while there is no relationship between the listing of Firms in emerging markets on LSE and the rate of SGR, while there is a negative relationship between FRO and SGR.
Research limitations; This research is limited to Firms listed on LSE and therefore the rest of the other European stock exchanges are excluded, this research is also limited to Egyptian Firms listed first in the Egyptian Stock Exchange and then listed on LSE and not Firms listed on LSE and then listed on the Egyptian Stock Exchange, as well as the research is limited to analyzing the financial reports of the issuing Firms in the local language
Practical implications: The results of this study are useful to the regulatory and supervisory authorities in developing countries, taking into account the objectives of Firms from listing in emerging markets and that there is a minimum limit for listing in global markets. In addition, current and potential investors should realize that simply listing the company on a foreign stock exchange does not necessarily mean the quality of financial reporting and sustainable growth rates, as well as financial institutions should not rely on the reputation gained by Firms listed on international stock exchanges, but must It do a good audit of the financial reports of Firms listed on international stock exchanges.
Originality/Value; This study is the first of its kind within the limits of researchers' knowledge, which deals with the impact of listing developing country Firms (Egyptian Firms as an example) on SGR, this study is the first of its kind (within the limits of researchers' knowledge), which focuses on listing emerging market Firms (Egyptian Firms as an example) on LSE without other stock exchanges and its impact on FRO and the SGR.
Pisa syndrome induced by discontinuation of low dose sulpiride: a case report
Authors: Koyama Genki , Nakano Masaki , Takata Taketo , Mimura Yu , Uchida Hiroyuki , Funayama Michitaka
Published: October 2024

Background
Pisa syndrome is a type of dystonia characterized by lateral flexion of the trunk, often induced by cholinesterase inhibitors and antipsychotics. Seemingly opposite hypotheses of the underlying mechanism have been proposed: cholinergic-dopaminergic imbalance toward cholinergic dominance and dopamine hypersensitivity associated with long-term antipsychotic administration.
Case presentation:
We herein report a case of a 64-year-old woman presenting with Pisa syndrome immediately after discontinuation of low dose sulpiride. To the best of our knowledge, this is the first case of Pisa syndrome induced by withdrawal of sulpiride, an antipsychotic that preferentially binds to presynaptic dopaminergic receptors at low doses, presumably resulting in increased dopaminergic action.
Conclusions
Our case not only supports the cholinergic-dopaminergic imbalance hypothesis as the mechanism underlying Pisa syndrome, but also suggests the paradoxical dopaminergic effects of sulpiride.
Population Genetic Structure Analysis of Anopheles kleini in the Republic of Korea based on the Mitochondrial COI Gene
Authors: Jung Haneul , Han Bo Gyeong , Ju Jung-Won , Lee Hee-Il , Shin Hyun-Il
Published: October 2024

Background
Anopheles kleini is a competent vector mainly observed in the northern malaria-risk areas of the Republic of Korea (ROK). In this study, the population genetic structure of An. kleini was analyzed for the first time in the ROK using the mitochondrial cytochrome c oxidase subunit Ⅰ (COI) marker.
Methods
The genetic structure of 249 An. kleini from three statistically analyzable regions was analyzed.
Results
Network analysis identified 140 haplotypes organized into three clusters. Cluster Ⅱ was related to An. kleini from eastern Russia and northwestern China. The pairwise genetic distance (FST) values among the populations showed regional genetic differences between Gangwon-do and Gyeonggi-do. Analysis of molecular variance (AMOVA) indicated that individual mosquitoes within the population had a significant influence on the total variation. The neutrality test, using three methods (Fu’s Fs, Fu, and Li’s D, and Fu and Li’s F), indicated that all values were negative, suggesting that An. kleini is an expanding population. An. kleini in Yanggu has a significant difference in genetic distance from other regions.
Conclusion
Based on molecular epidemiology, the spatial population structure of An. kleini is crucial in understanding the characteristics of An. kleini populations.
Diagnosis of Langerhans cell histiocytosis via percutaneous liver biopsy
Authors: Chen Qian-Qian , Zhao Chang , Shao Chun-kui , Zhang Yi-wang , Chen Jian-ning , Li Hai-feng , Liang Qiong
Published: October 2024

Background: The aims were to assess the clinical and histopathological characteristics of Langerhans cell histiocytosis (LCH) based on percutaneous liver biopsy and to improve the technique’s diagnostic accuracy.
Methods: Data from seven patients were collected. The clinicopathological features and immunophenotypes of hepatic LCH in the biopsied tissues were evaluated .
Results: Five men and two women (median age: 21 years) were included. The clinical presentations and imaging findings were unremarkable. In terms of the histological findings, multifocal and solitary lesions were detected in six patients and one patient, respectively. All lesions were located in the portal area and exhibited either enlarged or normal portal tracts. In four patients, Langerhans cells (LCs) were distributed either in clusters or scattered among mixed populations of inflammatory cells.LC invasion of the bile duct epithelium was detected in all but one patient; that individual presented with sclerosing cholangitis (SC) in the absence of LCs. One patient had a similar inflammatory myofibroblastic tumor (IMT) or inflammatory pseudotumor-like follicular dendritic cell (FDC) tumor. One patient had suppurative cholangitis with abscess formation, accompanied by a small degree of LC invasion into the bile duct epithelium.
Conclusions: The morphology of liver LCHs varied among patients. Bile duct epithelial damage accompanied by eosinophilic infiltration, a history of extrahepatic LCH, or central diabetes insipidus are clues that LCH may be present; however, H&E staining and IHC are crucial for its diagnosis. LCH should be differentiated from hepatic parasitic infections, primary SC, inflammatory pseudotumor-like FDC tumors, and inflammatory myofibroblastoma.
Falcon anti-quantum attack scheme based on 8-qubits channel RSP
Authors: Peng Kexin , Du Siyu
Published: October 2024

Quantum secure communication is divided into two key branches: quantum teleportation and quantum state remote preparation. The objective of quantum state remote preparation is to leverage classical communication and quantum entanglement for creating known quantum states at remote locations. Given that these known quantum states encompass amplitude coefficients, transmitting them over classical channels poses a security risk. This proposed solution emulates a scenario of three-party controlled remote preparation involving sender Alice, receivers Bob and Charlie, and controller Eve sharing an 8-bit quantum transmission channel. The plan entails preparing a dual quantum transmission channel at Bob and a triple quantum transmission channel at Charlie, followed by employing linear independent measurements and single quantum measurements, respectively. This approach effectively facilitates a positive operation at the receiving end to restore the original quantum state, ensuring secure quantum transmission. Furthermore, the solution integrates the Falcon post-quantum encryption algorithm for identity authentication on the amplitude coefficients, thereby thwarting potential information theft and tampering by malicious third parties. Through security analysis, efficiency comparisons, and validation via quantum simulators and Falcon code experiments, this solution notably enhances the efficiency of quantum state remote preparation while upholding performance integrity on classical channels. By enabling secure transmission on the channel, it enhances resilience against intermediary attacks.
Rapid Verbal Persuasion to Increase Influenza Vaccine Uptake: Protocol for a Randomized Hybrid Type 2 Effectiveness -Implementation Trial
Authors: Liu Siyuan , Gao Lan , Jin Yingying , Chen Jiangyun , Wu Dadong , Cai Yiyuan , Wang Tao , Huang Sanhao , Yan Ciling , Wang Run , Xu Dong (Roman)
Published: October 2024

Background
While influenza vaccines are the most effective measure for preventing influenza, uptake rates in China remain relatively low. Rapid Verbal Persuasion (RVP), due to its highly rapid fashion, involving just 1–2 minutes, has a strong evidence base in promoting behavior change. Despite this, it is underused or rarely evaluated in the context of vaccination. Additionally, the success of RVP implementation in vaccination clinics hinges on the motivation of the vaccination staff, which remains critical even with stable contextual factors. Multifaceted incentive-based implementation strategies, which aim to enhance motivation to promote the implementation of evidence-based practices, could be advantageous. This study protocol outlines an implementation-effectiveness hybrid type 2 design to evaluate the effectiveness of both the incentive-based implementation strategies on implementation outcomes and RVP on increasing influenza vaccination rates.
Method
This study will be conducted as a two-tiered cluster of randomized controlled trials over three months. Initially, 32 vaccination clinics will be randomly allocated to one of two study arms: (a) implementation of RVP or (b) no implementation. At the end of the study period, differences in influenza vaccination status between the intervention and control groups will be compared (primary outcome). Subsequently, a cluster randomized factorial trial will be conducted, involving 16 clinics implementing RVP. This trial will aim to compare the impact of various implementation strategies (different combinations of incentives) on fidelity in RVP implementation (Primary outcome). Data collection for the primary outcomes will include unannounced exit interviews. Modified Poisson regression models and generalized linear mixed-effects models will be utilized to analyze the association between primary outcomes and interventions.
Conclusion
The study aims to enhance the influenza vaccination rate in China by developing financial and non-financial incentives that allow vaccination staff to deliver RVP with greater motivation. Furthermore, the evidence generated from this multi-center trial will assist policymakers in improving current incentive systems within immunization services.
Number Line Estimation: another view in the light of the ACE, Arithmécole, and ELFE data.
Authors: Fischer Jean-Paul
Published: October 2024

Background. Numerous experimental or empirical papers using a number line estimation task have already been published. In this task, the participant must indicate the position of a number (e.g., 12) on a line bounded by two numbers (e.g., 0 and 100). However, the authors of these articles mainly sought to model the representation of numbers based on data obtained from participants.
Methods. This research draws on data from three French studies, each involving several thousand primary students, with an educational perspective. These data made it possible to investigate questions that have rarely been addressed, such as the singularity of this task and the asymmetry of the influence of the bounds. More importantly, they have enabled a systematic analysis of students' errors with the task presented in the form of multiple choice.
Results. Qualitative principal component and automated classification analyzes show some singularity of the number line task (in its multiple-choice exercise, at least). The asymmetry of the influence of the two bounds argues against the two main models in the literature—the logarithmic model and the linear model. The analysis of the approximately 100,000 students' erroneous choices reveals that they do not completely respect their distance to the correct choice: The expected order of choice through genuine estimation, that is first the correct number, then the nearest wrong number, then the middle wrong number and lastly the farthest wrong number, was not respected in more than half of the 46 number line estimation items. Furthermore, young children exhibited under-comprehension by confounding the magnitude of the target number with its position value, and educators or school authorities do not clearly understand the task or its modeling.
Conclusions. No model predicts all the observations, often original or curious, that we have made. Moreover, for theoretical reasons, we believe that the search for such a model is somewhat vain. In addition, we are sceptic about using the task for anything other than student assessment, given the distortions and difficulties that emerge from the children's erroneous choices, and from the practices of teachers and their supervisors also discussed in the article.
Reproductive Donors’ Needs and Preferences in the Process of Embryo and Gamete Donation: A Mixed-methods Systematic Review of the Current Evidence
Authors: Iranifard Elnaz , Roudsari Robab Latifnejad , Amirian Malihe , Zagami Samira Ebrahimzadeh
Published: October 2024

Background
Reproductive donation is a challenging task, in which donors’ needs are sometimes neglected. To provide reproductive donors with a well-structured, evidence-based and donor-centered care, it is important to acknowledge their needs. This study aimed to synthesize current evidence regarding donors’ needs and preferences.
Methods
This mixed-methods systematic review (MMSR) was conducted based on the recommended approach for MMSR by the Joanna Briggs Institute’s manual for data synthesis. The databases of ISI, PubMed, and Scopus were searched using the keywords of "egg donor", "sperm donor", "ovum donor", "gamete donor", "embryo donor", desire, expectation, preference, and need; without a time limit, up to September 2024. All the original research articles regarding reproductive donors’ needs, written in the English language were included in the study. Quality assessment was carried out using JBI tools for cross-sectional, cohort and qualitative studies. Data was integrated and synthesized by convergent integrated approach.
Results
Through data synthesis of 34 eligible articles, seven categories of reproductive donors’ needs emerged. These categories included 1) Need for support, 2) Informational needs, 3) Need for counseling, 4) Requirements for financial policies, 5) Preference towards recognition of donors’ rights, 6) Need for preserving donors’ dignity and respect, and 7) Desire for improvement of socio-cultural beliefs and public stigma of reproductive donation.
Conclusion
Various reproductive donors’ needs are not completely met by the current care provided by fertility clinics. Healthcare policymakers and fertility clinics must consider donors’ needs and preferences in policymaking and/or clinical practice to provide the service that donors deserve.
Registration:
The protocol of this systematic review is registered in PROSPERO (CRD42024588821).
Active compound profiling in fraction 49 of a secondary metabolite extract from Streptomyces hygroscopicus subsp. Hygroscopicus as antimalaria drug using LCMS, molecular docking, and molecular dynamics
Authors: Ardiyanti Sawitri Aji , Farahdina Afifah Aulia , Fitri Loeki Enggar , Widodo Nashi
Published: October 2024

Background Antimalarial resistance in Indonesia is caused by mutations at the drug target sites and biochemical changes in drug receptors. Previous research indicates that only fraction 49 of Streptomyces hygroscopicus Subsp. Hygroscopicus (S. hygroscopicus) is effective as an antimalarial agent in in vitro tests.Methods The active compounds of secondary metabolites from S. hygroscopicus were identified using LCMS. The binding of compounds to target proteins (PfK13, PfPM2, and PfAMA-1) underwent molecular dynamic simulations to estimate the stability and flexibility of the binding through the dynamic structure of the molecules.Results The LCMS analysis identified four compounds with the fastest retention times (indicating increased non-polarity): Dibutyl phthalate, Dihydroyashabushiketol, Dibenzylamine, and Sedanolide. These compounds meet drug-likeness criteria (Lipinski’s rule and Veber’s rule) and exhibit binding affinity values similar to the control for each target protein. Hydrogen and hydrophobic bonds formed between the compounds and targets show similarities with the bonds formed between the target proteins and their respective control ligands. The stability and flexibility of the molecular structures of the active compounds were assessed using molecular dynamics. Dihydroyashabushiketol exhibited the highest binding affinity and demonstrated a stable and flexible structure toward the target proteins PfK13 and PfAMA-1.Conclusion Dihydroyashabushiketol exhibits the highest binding affinity values in almost all target proteins compared to the other compounds, suggesting that Dihydroyashabushiketol has the potential as an antimalarial agent. The compound demonstrates a stable and flexible structure towards the target proteins PfK13 and PfAMA-1, but not towards the PfPM2 protein.
Optimizing Waste Management: The Impact of Pre-treatment on Black Soldier Fly Larvae for Sustainable Protein Sourcing
Authors: HERVE MUBE KUIETCHE , Lionel Gagueng F. , Daniel Dzepe , Ndomou Serge. C. H. , Chia Shaphan Y. , Raphael Kana Jean , Augustave Kenfack , Rousseau Djouaka , Ndindeng Sali A.
Published: October 2024

Amidst escalating global urbanization and population growth, the necessity to revolutionize food systems and redefine waste management strategies has become paramount. This study aimed to contribute to the evolution of protein resource diversification within animal feed and offer a sustainable solution for organic waste management using black soldier fly larvae (BSFL) in Bafia, Cameroon. A survey characterized waste production in both restaurants and households to assess their quantity and quality. Subsequently, collected organic wastes were subjected to two pre-treatments: heating (60°C) and fermentation (4 days), while another batch was used fresh as feeding substrates for BSFL in comparison to a broiler starter diet in a 17 days larval feeding experimental period. Throughout the study period, various parameters were evaluated, including physicochemical properties of substrates, bioconversion and growth parameters, life cycle traits of adult BSF, and the nutritional composition of the larvae. The survey revealed a significant disparity in food waste disposal practices: while 98% of restaurants disposed of waste indiscriminately, 95% of households reported using food waste as fertilizer.In the experimental phase, heat treatment exhibited the highest substrate temperature and pH levels throughout the experimental period. Larvae reared on heated substrates showed superior daily weight gain (0.05g/larva/day) and bioconversion rate (41.76%) compared to other substrates. Additionally, larvae from heat-treated substrates had highest lipid (35%) and protein (29.89%) contents compared to all other organic waste treatments, although his protein content remained lower than that of the chick’s starter diet, which had a higher value (37.53%). Notably, flies from larvae reared on heated substrates emerged two days earlier than those from other treatments. These early-emerging adults lived longer and produced more eggs than their counterparts. This study has revealed a stark contrast in the disposal practices of food waste between restaurants and households in Bafia. The findings underscore the potential of utilizing waste, especially after heat pre-treatment, to produce high-quality black soldier fly larvae, offering a promising avenue for sustainable protein sourcing in animal feed while addressing organic waste management challenges.
Eccentricity excitation equation and its underlying mechanism: Orbital precession mechanism
Authors: Dai Yong-Feng
Published: October 2024

This study addresses the problem of orbit formation in planetary (including planet−moon), binary, and hierarchical triple systems by proposing an eccentricity excitation equation and investigating its underlying mechanism. The study introduces a synchronous orbit radius ratio and investigates the relationship between the semi-major axes and synchronous orbit radius ratios of known eccentric systems with similar mass ratio orders of magnitude and spin–orbit angles to discover the eccentricity excitation equation. In an eccentric system with a mass ratio order of magnitude higher than −7.5217, the semi-major axis exhibits a power-law distribution relationship with the product of mass ratio and square of rotation period ratio. By assuming that a gravitational field rotates along with the host celestial body, this study extends Einstein’s equivalence principle to analyze the mechanism underlying the eccentricity excitation equation. A frame exists in local physical space of a rotating gravitational field, which replaces gravity and exhibits a free-fall acceleration toward the host and an acceleration from an initial zero velocity to current velocity of the gravitational field. This frame can be divided into two subframes, one of which can be replaced by the drag force. The orbital eccentricity results from the combined effect of two drag forces caused by the gravitational field rotation of the primary and secondary bodies in a system. Moreover, a power-law relationship exists between the orbital velocity forming the semi-major axis caused by the drag force due to the gravitational field rotation of the secondary body and the ratio of the two drag forces. Orbital precession is driven by the drag force acting on the secondary body only in the aphelion region and is positively correlated with the eccentricity.
Modeling Regional Determinants of Early Motherhood in Colombia and its impact during COVID-19 pandemic
Authors: RAMIREZ FABIAN A DAVILA , Cala-Viteri Favio
Published: October 2024

Introduction: Early motherhood, defined as occurring in women under 19 years of age, poses significant social challenges with immediate and long-term consequences. This study focuses on early fertility rates (early motherhood) in Colombia and examines their relationship with social and demographic factors.
Methods: Departmental-level data from Colombia's Social Protection Information System (RUAF) and the National Administrative Department of Statistics (DANE) were cleaned and aggregated from 2018-2023. This allowed the estimation of the overall fertility rate, infant fertility rate, and adolescent fertility rate by department and year. A model was constructed to estimate the influence of recognized risk factors such as low educational attainment (% of undereducated population), poverty level (% of population under subsidized health schemes, current GDP), employment rates (% of workforce participation), violence against women (% of female deaths, both general and violent), and infant mortality. The model was refined to improve performance by removing variables with low contributions to early motherhood.
Results: Fertility indicators focusing on early fertility in Colombia were described. Regions that should be prioritized for early fertility prevention strategies were identified because of their increase in the early pregnancy rate during the pandemic. Significant risk factors included the percentage of the population under subsidized health schemes, GDP per capita, percentage of violent deaths, percentage of female deaths, and percentage of deaths among those <18 years of age.
Conclusions: We identified regions that should be prioritized for early fertility prevention strategies, highlighting areas particularly vulnerable to increased early fertility rates during the pandemic. These findings reveal the effects of relaxed public health measures alongside the social and demographic factors needed for targeted interventions. Further research is necessary to quantify the impact of specific interventions on early fertility rates.
(Notwendige) Kompetenzen in digital vernetzten Welten für Teilhabe und souveränes Handeln
Authors: Knop Karin
Published: October 2024

Rezension zu
Cousseran, Laura, Achim Lauber, Simon Herrmann, und Nils Brüggen. 2023. Kompass: Künstliche Intelligenz und Kompetenz 2023. Einstellungen, Handeln und Kompetenzentwicklung im Kontext von KI. Herausgegeben vom JFF – Institut für Medienpädagogik in Forschung und Praxis. München: kopaed. 16,80 €. https://doi.org/10.5281/zenodo.10058587.
und
Schober, Maximilian, Katja Berg, und Nils Brüggen. 2023. KI als «Wunscherfüller»? Kompetenzen von Kindern im Umgang mit algorithmischen Empfehlungssystemen. Qualitative Studie im Rahmen von «Digitales Deutschland». Herausgegeben vom JFF – Institut für Medienpädagogik in Forschung und Praxis. München: kopaed. 14,80 €. https://doi.org/10.5281/zenodo.10171263.
Strategic Management of a Company’s Employer Brand: Experience of International Companies
Authors: Trunina Iryna , Pryakhina Kateryna , Bilyk Maryna
Published: October 2024

This article examines the strategic management of employer branding in multinational companies and its significantly positive impact on talent acquisition and retention. In today’s competitive global marketplace, a robust employer brand is essential for organisations aiming to distinguish themselves and retain top talent. The concepts of employer brand development, talent acquisition, and employee loyalty assessment are challenging to monitor in the current domestic business environment. This raises the question of how companies with successful employer brands have developed their strategies and continue to sustain them in the marketplace.Therefore, the aim of this study is to develop strategic directions for the formation of the employer brand and its further alignment on the basis of the synthesis of successful practices from international technology companies. The employer brand diagnostic procedureincludes three steps. The first step includes a general analysis of the employer brand of companies, such as the international companies Apple, Google and Microsoft, and a research roadmap of the mission and goals of the employer brand of international companies. The second step is to monitor the components of the employer’s internal and external brand. The third step is to assess employee loyalty with eNPS. It is argued that organisations should integrate the mission, vision and objectives of their employer brand and HR strategy with the overall mission, vision and strategy of the company. This alignment is critical to developing a cohesive corporate culture and, as a result, developing a clear employer brand value proposition. Managing employee loyalty is a critical aspect of employer brand monitoring, as it is necessary to maintain a positive work environment and establish effective external communication to nurture employer brand ambassadors. The developed strategic directions, which are based on the positive practices of international companies with developed employer brands, have practical applications for companies that want to manage the value proposition of their employees and align their employer brand identities.
Financial Justification for the Use of Innovative Digital Marketing Tools
Authors: Tataryntseva Yuliia , Manoylenko Oleksandr , Shmatko Nataliia
Published: October 2024

This article presents a comprehensive study aimed at analysing the impact of innovative digital marketing tools on the promotion of dairy products. This study is relevant because of the rapid dynamics of the digital environment and the need for enterprises to adapt to new marketing trends. The article investigates the feasibility of using innovative digital marketing tools in accordance with the segments of the target audience on the basis of the definition of their values. The main problem is the lack of scientific justification for the choice of innovative digital marketing tools for potential audiences, as well as the analysis of the feasibility of digital marketing costs. The hypothesis of the study is that, on the basis of the analysis of the values of consumer groups, as well as the analysis of the feasibility of marketing costs, it is possible to select the most relevant innovative digital marketing tools. The main purpose of the study is to justify the use of innovative digital marketing tools on the basis of consumer values, as well as to justify the feasibility of digital marketing costs on the basis of the analysis of financial statements. The methodology included cluster analysis of the target audience and analysis of financial ratios. One of the key stages of the study was the cluster analysis of the target audience, which allowed us to identify different consumer segments with different needs and values. Three clusters of consumer audiences in the dairy industry were identified, the corresponding values of customers in the clusters were substantiated, and recommendations for identifying innovative digital marketing tools were proposed, taking into account the feasibility of the marketing costs of the enterprise. The key coefficients for making informed management decisions on the feasibility of digital marketing costs are allocated. By analysing these coefficients, an enterprise can assess its financial capabilities and make a decision on how to invest in innovative digital marketing tools. This allows enterprises to make informed decisions about investing in digital marketing, minimizing financial risk and increasing the chances of successful implementation of marketing strategies. This study significantly adds to the body of knowledge in the field of digital marketing by offering a scientifically based approach to the selection of innovative marketing tools on the basis of the analysis of consumer value and the financial feasibility of costs. The practical application of the research results lies in the ability of dairy enterprises to promote their products online on the basis of a thorough selection of innovative digital marketing tools, reducing financial risk. This creates a basis for further research in the field of digital marketing, particularly in the context of the integration of innovative digital marketing tools and their impact on consumer behaviour.
Effect of Storage Temperature on Fruit Hardness and Anthocyanin Biosynthesis in Red Peeled Banana (Musa acuminata Hongmeiren)
Authors: Huang Yuji , Kou Ping , Luo Jie , Chen Chunling , Li Jinman , Lai Zhongxiong , Miao Lixiang , Chen Yiting
Published: October 2024

Bananas (Musa spp.) are a popular tropical fruit grown worldwide and are typically harvested when 70% to 80% plump. Postharvest storage is crucial for maintaining fruit quality, with temperature playing a key role due to banana sensitivity to low temperatures. Red peeled bananas, such as the cultivar Hongmeiren, stand out for their unique red peel and pink pulp when ripe. These bananas offer nutritional benefits and are rich in anthocyanins compared with yellow bananas. This study focused on the hardness change, anthocyanin content, and the expression of related genes in red peeled bananas at different temperatures. Results showed that pulp hardness reached an edible state after 4 days at 19 and 25 °C, with stability thereafter. Storage time at 10 °C was longer and anthocyanin content remained stable across temperatures. Gene expression analysis indicated that genes including MaPAL, MaCHS, MaCHI, MaDFR, and MaANS related to anthocyanin synthesis were highly expressed at 10 °C, potentially preserving anthocyanin content and fruit appearance. Although higher anthocyanin content was observed at 19 and 25 °C, black spots appeared on the fruit peel after 8 days, affecting its quality. After 30 days of storage at 10 °C, a significant number of black spots appeared on the peel of the fruit, leading to a gradual loss of its nutritional value. This study indicates that red peeled bananas can be stored for longer periods while maintaining their appearance quality at 10 °C, as opposed to 19 and 25 °C. Hence, it is recommended to store red peeled bananas at low temperatures, especially following ethylene treatment or during periods of high temperatures.
Application of Arbuscular Mycorrhizal Fungi for Improved Growth and Acclimatization of Micropropagated Fegra Fig (Ficus palmata Forssk.) Plantlets
Authors: Dewir Y. H. , Al-Aizari A. A. , Al-Obeed R. S. , Alshahrani T. S. , Habib M. M. , Malik J. A. , Al-Qarawi A. A. , Alwahibi M. S.
Published: October 2024

Fegra fig (Ficus palmata) is an important fruit-yielding crop and potential rootstock for grafting Ficus carica. The acclimatization phase is a pivotal step during the micropropagation of plants. During this study, the mycorrhization of micropropagated fegra fig plants with two arbuscular mycorrhizal fungi (AMF; Gigaspora margarita and Gigaspora albida) to enhance their growth and survival during the acclimatization stage was investigated. The AMF were mixed in equal proportions and the acclimatizing fegra fig plantlets were treated for 8 weeks. The leaf pigments, i.e., chlorophyll a [2.56 mg·g−1 fresh weight (FW)], chlorophyll b (1.08 mg·g−1 FW), total chlorophyll (3.67 mg·g−1 FW), and carotenoid (1.34 mg·g−1 FW), of AMF-treated plants were higher than those of non-AMF plants. The number of stomata per unit was higher in the AMF-treated plants (16.00), the density of stomata per unit area (88.40 mm2) of AMF-treated plants was similar to that of non-AMF treated plants, and the number of epidermal cells (79.00) was higher in the AMF-treated plants. The AMF-treated plants were taller and had more leaves, a greater leaf area, and higher shoot FW and dry weight. The AMF-treated plants also had the greatest total root length values, greatest surface areas of roots, and greatest total root volume and diameter compared to those of non-AMF plants. Additionally, the AMF-treated plants had a 100% survival rate, whereas a survival rate of 95% was recorded for non-AMF plants. These findings emphasize the importance of biological acclimatization of micropropagated fegra fig plants with AMF.
The Analysis of the Fetal Abdominal Wall and Gastrointestinal Tract Abnormalities in a Single Tertiary Center
Authors: Bolluk Gökhan , Oğlak Süleyman Cemil , Çetinkaya Merih , Turan Bakirci Isıl , Demirali Oyhan , Cok Mehmet , Turhan Karakus Handan , Onur Yasin , Yilmaz Emine Zeynep
Published: October 2024

OBJECTIVE: We aimed to evaluate the fetuses with gastrointestinal anomalies and anterior abdominal wall defects detected in the prenatal period in our clinic and to analyze their perinatal outcomes.
STUDY DESIGN: This retrospective study analyzed the data of 67 cases evaluated by the perinatology department of the Basaksehir Cam and Sakura City Hospital between January 2021 and May 2023 with a diagnosis of fetal anterior abdominal wall and gastrointestinal tract abnormalities.
RESULTS: A total of 67 cases were included in our study with a mean maternal age of 26.4 ± 3.1 years and a median gestational week of first assessment at our center of 22 weeks (12-39 weeks). The most common anterior abdominal wall malformations were omphalocele (n=29, 43.3%) and gastroschisis (6 cases, 9.0%), and the most common fetal gastrointestinal tract anomalies were duodenal atresia (n=10, 14.9%), dilated bowel (n=5, 7.4%), and intestinal atresia (n=4, 5.9%). While genetic testing was carried out in 18 cases (27%), chromosomal abnormality was found in 6 (9.0%) cases. Termination of pregnancy was performed in 6 cases (9.0%). Postnatally, surgery was performed in 49 cases (73.1%) with a diagnosis of postpartum omphalocele, duodenal atresia, gastroschisis, intestinal and anal atresia. An uneventful surgical course was recorded for 47 cases that underwent surgery.
CONCLUSION: The most common abdominal wall defects are omphalocele and gastroschisis, and the most frequent gastrointestinal anomalies are small bowel abnormalities (duodenal atresia, dilated bowel, intestinal atresia) in our study cohort. These abnormalities might be an isolated anomaly or part of a syndrome or associated with chromosomal abnormalities. The prognosis for infants with gastrointestinal malformation depends on the presence of associated anomalies or karyotype anomalies.
Ganga, GAP, and lockdown: potential threats to the biodiversity of the river
Authors: Rai Prabhakar , Kumar Joseph Stanley Yogesh , Sen Arya
Published: October 2024

The Ganges River holds a vital status within India as a cornerstone of the nation's ecological and socio-economic fabric. Flowing through diverse terrains like the Himalayas, Gangetic plains, and coastal regions, it fosters an incredibly rich biodiversity, supporting a myriad of life forms ranging from microorganisms to mammals. Beyond its ecological significance, the river sustains the livelihoods of millions, contributing significantly to the economy of northern India. However, rampant human development over recent decades has posed grave threats to its well-being. Pollution from sewage and industrial waste has tainted its waters with heavy metals, posing risks of bioaccumulation and magnification within aquatic life. Infrastructure projects like dams and bridges disrupt natural habitats and impede the migration of aquatic species, further jeopardising the river's ecological balance. Despite these challenges, there have been glimmers of hope, particularly noted during the COVID-19 lockdown when industrial activities ceased, offering the river a temporary reprieve. Moving forward, effective measures are imperative, including reducing industrial and domestic effluent discharge, scrutinising sources of heavy metal contamination, and prioritising the restoration of the river's natural flow. Preserving the Ganges’ ecological integrity is paramount, necessitating concerted efforts to ensure its health and vitality for future generations.
Resilience, Dispositional Hope, and Psychological Well-Being Among College Students: A Systematic Review
Authors: Yan Zheng , Zakaria Ezarina , Akhir Noremy Md , Hassan Nazirah
Published: October 2024

Background

Mental health problems are a typical occurrence for college students. Resilience and dispositional hope are crucial in positive psychology and constitute essential psychological capital that collectively promotes psychological well-being. However, limited evidence exists regarding the interplay of resilience, dispositional hope, and psychological well-being across diverse cultures and countries.

Objective

This study aims to synthesize evidence on how resilience, dispositional hope, and psychological well-being interplay across different cultures among college students.

Methods

Six databases were searched comprehensively, adhering to PRISMA guidelines. Initially, 122 articles were identified, with 26 duplicates removed, leaving 96 papers for further evaluation. Subsequently, two separate reviewers evaluated the titles and abstracts of these papers using predefined inclusion criteria, identifying 39 articles for detailed full-text review. Among these, 9 studies were extracted and subjected to rigorous quality assessment.

Results

The article highlights hope and resilience's protective role against stress, anxiety, depression, and academic burnout. Psychological strengths such as resilience and hope significantly enhance well-being. Cultivating these constructs alongside coping strategies and support systems is vital for flourishing among college students.

Conclusion

This systematic review is the first to comprehensively summarize evidence regarding the interplay between college students' psychological well-being, dispositional hope, and resilience. Future research should employ diverse methods for a nuanced understanding, focusing on cross-cultural comparisons.
Oral and Long-acting Injectable Aripiprazole in Severe Mental Illness and Substance Use Disorder Comorbidity: An Updated Systematic Review
Authors: Santorelli Mario , Miuli Andrea , Pettorruso Mauro , Di Carlo Francesco , De Berardis Domenico , Sensi Stefano L. , Martinotti Giovanni , Clerici Massimo , di Giannantonio Massimo
Published: October 2024

Background:

Co-occurrence of substance use disorders is frequent in patients with mental
health disorders is a condition known as “dual diagnosis”. The use of substances worsens the prognosis
and lowers the quality of life of psychiatric patients. It also increases the risk of hospitalization and
suicide rate.

Objectives:

To assess the effects of aripiprazole therapy on substance use and other psychiatric outcomes
in dually diagnosed patients.

Methods:

We performed a systematic review conducted on 3 databases PUBMED, SCOPUS, and
Web of Science, selecting original studies and analyzing the impact of aripiprazole therapy on dually
diagnosed patients. Six hundred and fifty-five articles were founded and, after removing duplicates
(n = 274) and applying the exclusion criteria, 12 articles were included in our systematic review.

Results:

12 studies were included, among which 6 were Randomized Controlled Trials. The Most frequent
psychiatric diagnosis were schizoaffective disorders, schizophrenia, and bipolar disorders. Alcohol
and cocaine use disorders were the most used substances. Eleven studies showed a clinical improvement
after aripiprazole treatment. 8 studies evaluated craving and found a significant reduction
after treatment with aripiprazole. No definitive conclusions can be drawn on substance usage and
maintenance of abstinence.

Conclusion:

The present findings suggest aripiprazole may be associated with reducing substance craving
and improving depression, psychosis, and schizoaffective disorders in dually diagnosed patients.