bluuebunny/crossref_metadata_2025 huggingface dataset:
Recalcitrant Grover’s Disease Successfully Managed with Dupilumab and Naltrexone in a Middle-Aged Woman: A Case Study
Authors: Beiter Kaylin , Behnam Christy , Shields Bridget
Published: July 2023

Introduction: Grover’s disease, or transient acantholytic dermatosis, is a common benign papulovesicular disorder that often affects elderly men. It is typically managed with topical therapeutics in this population. We present here an uncommon case of Grover’s disease, occurring in a relatively younger patient, that was recalcitrant to typical therapeutics modalities.
Case Report: A 45-year-old woman presented to our clinic with a several month history of discrete, pink, ill-defined pruritic papules on her torso with sparing of her extremities. Grover’s disease was diagnosed based on her clinical presentation and subsequently biopsy-confirmed. She failed multiple topical medications, oral acitretin, and only experience minimal relief when transitioned to Naltrexone. Dupilumab was added to her regimen, with rapid improvement. She was eventually transitioned down to dupilumab monotherapy, and has remained clear since. 
Conclusion: Grover’s disease is not common among middle-aged women. Novel therapies, such as biologics, have been efficacious in elderly (especially male) populations with this condition. Our case demonstrates the importance of attempting new treatment modalities such as dupilumab for patients with recalcitrant disease. Novel application of these biologic treatments may be needed in particular for atypical cases, such as when patients do not fit the known epidemiologic profile.
Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor, in Moderate to Severe Plaque Psoriasis: Efficacy by Baseline Demographic and Disease Characteristics in the Phase 3 POETYK PSO-1 and PSO-2 Trials
Authors: Gooderham Melinda , Spelman Lynda , Imafuku Shinichi , Romanelli Marco , Merola Joseph F. , Armstrong April W. , Colston Elizabeth , Banerjee Subhashis , Scharnitz Thomas , Blauvelt Andrew
Published: July 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the US and other countries for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. In the POETYK PSO-1 (NCT03624127) and PSO-2 (NCT03611751) trials, deucravacitinib was superior to placebo and apremilast in patients with moderate to severe plaque psoriasis. This analysis evaluated deucravacitinib efficacy by baseline characteristics.

Methods: Efficacy endpoints, including ≥75% reduction from baseline in Psoriasis Area and Severity Index (PASI 75) and static Physician’s Global Assessment score of 0 (clear) or 1 (almost clear) (sPGA 0/1), were evaluated at Week 24 by baseline subgroups including weight, sex, and PASI in the pooled PSO-1 and PSO-2 population, and at Week 52 in PSO-1 patients who received continuous deucravacitinib treatment from Day 1.

Results: In the pooled PSO-1 and PSO-2 population, deucravacitinib (n=843) was more efficacious than apremilast (n=422) at Week 24 across subgroups defined by baseline weight (<90 kg: PASI 75, 69.8% vs 43.8%, sPGA 0/1, 60.2% vs 34.2%; ≥90 kg: PASI 75, 55.4% vs 31.5%, sPGA 0/1, 45.9% vs 25.6%), sex (male: PASI 75, 59.3% vs 33.7%, sPGA 0/1, 49.6% vs 24.7%; female: PASI 75, 70.4% vs 45.2%, sPGA 0/1, 60.9% vs 39.4%), and PASI (≤20: PASI 75, 61.6% vs 38.6%, sPGA 0/1, 53.5% vs 32.4%; >20: PASI 75, 64.7% vs 37.0%, sPGA 0/1: 53.2% vs 27.1%). Consistent efficacy was observed through Week 52 in patients who received continuous deucravacitinib treatment in PSO-1 (n=332), regardless of baseline characteristics.

Conclusion: Deucravacitinib demonstrated consistent efficacy for up to 52 weeks regardless of baseline characteristics in patients with moderate to severe plaque psoriasis.

 

Acknowledgments

This study was sponsored by Bristol Myers Squibb

Writing and editorial assistance was provided by Liz Rockstein, PhD, of Peloton Advantage, LLC, an OPEN Health company, funded by Bristol Myers Squibb
Safety of Tazarotene 0.045% Lotion and Hyperpigmentation Improvements in Black Participants With Moderate-to-Severe Acne
Authors: Cook-Bolden Fran , Stein Gold Linda , Baldwin Hilary , Callender Valerie , Alexis Andrew , Bhatia Neal , Zeichner Joshua , Tanghetti Emil , Guenin Eric
Published: July 2023

Introduction: Post-inflammatory hyperpigmentation (PIH) that results from acne in patients with skin of color may be more distressing than the acne itself, and likely impacts patients with higher skin phototypes more greatly than those with lower skin phototypes. Topical retinoids, a mainstay of acne treatment, can also reduce hyperpigmentation. For example, significant PIH improvements with a cream formulation of the retinoid tazarotene (0.1%) were observed following 16 weeks of treatment in patients with acne. However, skin irritation and other skin reactions may limit use of some tazarotene gel and cream formulations. A hydrating, lower-dose tazarotene 0.045% lotion formulation utilizes polymeric emulsion technology to allow for more efficient delivery of tazarotene into dermal layers while reducing potential for skin irritation. This pooled, post hoc analysis evaluates safety of tazarotene 0.045% lotion and its effect on hyperpigmentation in Black individuals with acne.

Methods: In two identical phase 3 randomized, double-blind, vehicle-controlled, studies (NCT03168321; NCT03168334), participants aged ≥9 years with moderate-to-severe acne (Evaluator's Global Severity Score of 3/4) were randomized (1:1) to once-daily tazarotene 0.045% or vehicle lotion for 12 weeks. Safety evaluations included adverse events (AEs) reports and investigator-assessed hyperpigmentation (4-point scale: 0 [none] to 3 [severe]). Post hoc analyses were based on participants’ self-identification of race, including ‘Black or African American’ (herein referred to as Black).

Results: Of 1,614 participants randomized in the two phase 3 studies, 262 (16%) self-identified as Black. The safety population comprised 253 Black participants. The most common TEAEs with tazarotene 0.045% lotion were at the application site: pain (6.6%), exfoliation (5.0%), and dryness (3.3%). No Black participants reported application site irritation or dermatitis with tazarotene lotion. Hyperpigmentation rates in Black participants, which were high at baseline, decreased by week 12 with tazarotene treatment (40.5% to 31.4%) compared to vehicle (37.9% to 37.2%).

Conclusions: Acne regimens that maximize efficacy while mitigating irritation is key to managing acne in patients with skin of color, given the higher pigmentary alteration risk in melanin-rich skin. Tazarotene 0.045% lotion was safe and well tolerated in Black participants, with no application-site irritation or dermatitis after 12 weeks of once-daily treatment. Tazarotene also led to improvements in hyperpigmentation, an inflammation-associated sequala of acne. As PIH can take longer than 12 weeks to resolve with treatment, additional improvements in hyperpigmentation may be expected with continued tazarotene 0.045% lotion use.

Support: Ortho Dermatologics.
Impact of Age or Sex on Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.1%/Adapalene 0.15% Gel in Participants with Moderate-to-Severe Acne
Authors: Stein Gold Linda , Kircik Leon , Werschler William , Baldwin Hilary , Callender Valerie , Green Lawrence , Sadick Neil , Sugarman Jeffrey , Draelos Zoe , Tanghetti Emil , Bhatia Neal
Published: July 2023

Introduction: IDP-126 (clindamycin phosphate 1.2%/benzoyl peroxide [BPO] 3.1%/adapalene 0.15%) polymeric mesh gel is the first triple-combination, fixed-dose topical acne treatment in development. IDP-126 demonstrated superior efficacy to vehicle and component dyads, with good safety/tolerability, in a phase 2 and two phase 3 studies of participants with moderate-to-severe acne. The objective of this analysis was to assess the impact of age or sex on efficacy and safety/tolerability of IDP-126 gel.

Methods: This post hoc analysis evaluated effect of age or sex on efficacy/safety of IDP-126 using data pooled from two phase 3, double-blind, randomized, 12-week studies (NCT04214639, N=183; NCT04214652, N=180). Participants aged ≥9 years with moderate-to-severe acne were randomized 2:1 to once-daily IDP-126 gel or vehicle gel. Data were analyzed by age (pediatric [9-17 years]: n=178; adult [≥18 years]: n=185) or sex (females: n=212; males: n=151). Endpoints included ≥2-grade reduction from baseline in Evaluator’s Global Severity Score and clear/almost clear skin (treatment success) and least-squares mean percent change from baseline in inflammatory and noninflammatory lesion counts. Treatment-emergent adverse events (TEAEs) were also assessed.

Results: At week 12, over half of pediatric and almost half of adult IDP-126-treated participants achieved treatment success (52.7% and 45.9%, respectively) versus one-fourth with vehicle (24.0% and 23.5%; P<0.01, both). Results by sex were similar (IDP‑126 vs vehicle: females: 53.7% vs 23.0%; males: 43.1% vs 24.6%; P<0.05, both). IDP‑126 provided >70% reductions in inflammatory and noninflammatory lesions in all subgroups, versus 41%-63% with vehicle (P≤0.001, all). Differences between sex or age groups were not statistically significant. Most TEAEs were of mild-moderate severity in all groups.

Conclusions: Fixed-dose, triple-combination IDP-126 gel was efficacious and well tolerated in participants with moderate-to-severe acne, regardless of age or sex, with approximately half of participants achieving clear/almost clear skin.

Funding: Ortho Dermatologics
Formulation and Evaluation of Probiotics Properties of Lactobacillus with Antimicrobial Activities
Authors: Patil Abhinandan , Tamboli Firoj , Gaikwad Dinanath , Mudalkar Pralhad , Alaskar Kamal
Published: July 2023

This study emphasizes exhibiting probiotics activities of Lactobacillus, formulation as granules, synthesizing nanoparticle by using Lactobacillus and demonstrating antimicrobial activity. Probiotics are not only microbes present in milk but also as are functional food to heal diseases. Four different isolates were obtained from sheep milk. These microbe’s growth profile was observed in different animal milk, and some biochemical studies were conducted. All four isolates were tested against gram positive and negative microorganisms like Salmonella typhi, Escherichia coli, Proteus vulgaris, Enterococcus faecalisis, Staphylococcus aureus etc. The nanoparticles of TiO2 was developed by using LAB via green synthesis. Granules of probiotics were prepared by using maltodextrin as agent by a lyophilization drying technique. The flow properties were studied for the prepared granule as formulation. The colony forming unit observed in case milk of buffalo was higher (12* X 109 CFU ± 2.5) which was observed in the other milking animals milk. The four isolates were identified as Lactobacillus (LAB) by Gram staining, motility catalase activity, along with other biochemical assays. The mimicking in-vitro simulation study showed higher survival rate in the intestine, demonstrated by bile salt studies. Microbes as a whole showed a good zone of inhibition as compared to the supernatant. Finally, these isolates have proven to be a good probiotic candidate that can be used as a natural antibiotic agent as a nutraceutical nominee. Granules exhibit good flow properties in case of all LAB formulations. The green synthesis of nanoparticles from LAB was observed at the absorption band at 405 to 410 nm using the UV method. LAB extracted from sheep milk was proven in the current investigation exhibiting as a potential candidate for the future probiotic antibacterial agent that resists GI environment.
A Critical Study on the Synthetic Medication Pattern in the Management of Rheumatoid Arthritis
Authors: V.S Chauhan , Avijit Mazumder , Shobhini Chandel
Published: July 2023

An inflammatory condition known as arthritis affects one or more joints in the body. The pathophysiology of rheumatoid arthritis (RA), a diverse ailment with a complicated and still poorly known pathogenesis, involves many different cell types in the destruction of the joints. Due to this complexity, clinical course and severity vary widely amongst patients and genetic and/or environmental factors may also impact them. In addition to the conventional synthetic disease-modifying anti-rheumatic drugs, biologics have demonstrated efficacy and safety in symptomatic relief, reducing bone loss, and maintaining the function, which has considerably improved the treatment of rheumatoid arthritis. Since current drugs periodically fail, only substantially treat the ailment or have unfavorable side effects. There are still unmet treatment requirements in rheumatoid arthritis despite the availability of a wide range of therapeutic choices and their combinations. Unfortunately, the ‘nonresponse’ pathways are still not fully understood, although they most definitely have to do with the covert variability of the pathophysiology of the disease. In this research, we will narrate the current and upcoming biological treatments and their cellular aims.
Exploring the Potential of Eclipta alba: A Promising Approach for Hair Treatment Management through 5-Alpha Reductase Inhibition
Authors: Chakraborty Arpan , Bhattacharjee Arka , Mondal Baishakhi , Chakraborty Manas , Mukhopadhyay Goutam , Ghosh Maitrish , Majumder Alpana
Published: July 2023

A class of medications known as 5 alpha reductase (5α-reductase or 5αR) inhibitors is used to treat male pattern hair loss and benign prostatic hyperplasia. This study shows that Eclipta alba has 5αR inhibitory action that is helpful in the treatment of androgenic diseases. For 5αR enzyme inhibition evaluation, E. alba was extracted using methanol and petroleum ether. Further phytochemical screening can be done. Phytosterols test negatively found in methanol extract during phytochemical screening but positive in petroleum ether extract of E. alba. HPTLC data of different extracts was performed based on the phytochemical screening found. According to the HPTLC analysis, petroleum ether extract of E. alba contained 0.11% of β-sitosterol, while the methanolic extract had a higher concentration of 4.75%. The inhibitory activity of these plant extracts against 5αR was examined in comparison to the commonly used 5αR inhibitor, finasteride. IC50 measurements for petroleum ether extract of E. alba and β-sitosterol (a chemical biomarker derived from the plant material) were established as 150.76 ± 4.56 and 77.09 ± 3.07 μg/mL, correspondingly. These results indicate their potential as compelling contenders worthy of deeper exploration regarding their anti-androgenic properties. The notable abundance of β-sitosterol in the petroleum ether extract of E. alba enhances its potential for significant biological activity, particularly in terms of inhibiting the 5αR enzyme.
Rare lung cancer subtype discovery by bone metastases: Synchronous traits
Authors: El Alami Souhail , Laraichi Ayoub , Abakka Mehdi , El Ghoul Naoufal , El Aouni Soukaina , Bennis Azzelarab , Zaddoug Omar , Zine Ali , Benchakroun Mohammed , Tanane Mansour , Bouabid Salim
Published: July 2023

This study investigates the synchronous traits of a rare lung cancer subtype, specifically Large Cell Neuroendocrine Carcinoma (LCNEC), discovered through bone metastases. Bone metastases are a common occurrence in lung cancer, significantly impacting the quality of life and survival of patients. Synchronous bone metastasis (SBM), defined as bone metastases diagnosed within three months of lung cancer diagnosis, and metachronous bone metastasis (MBM), diagnosed more than three months after lung cancer diagnosis, exhibit distinct clinicopathological characteristics, therapeutic sensitivities, and prognostic outcomes. This article presents a visual case discussion of a 64-year-old male patient who experienced a pathological fracture of the proximal femur, leading to the incidental discovery of LCNEC through bone biopsy. Further imaging and diagnostic tests confirmed the presence of a primary lung tumor and bone metastases. The treatment approach for LCNEC remains challenging due to limited data and varying outcomes reported in the literature, however our patient received cisplatin with etoposide chemotherapy following fracture management. The findings emphasize the importance of recognizing rare lung cancer subtypes, such as LCNEC, through bone metastases and tailoring individualized treatment plans.
İç göç ve ekonomik büyüme arasındaki ilişkinin mekansal analizi: Türkiye örneği (2008-2020)
Authors: YÜRÜK Burcu , BATMAZ Türker
Published: July 2023

İç göç, ülkenin demografik yapısını ve ekonomisini etkileyen önemli bir faktör olarak karşımıza çıkmaktadır. Türkiye’ de son yıllarda iş imkanları, eğitim, sağlık hizmetleri vb. temel ihtiyaçlarla yaşanan iç göç; nüfus, işgücü piyasası, üretim yapısı vb. nedenlerle ekonomik büyüme üzerinde etkili olmaktadır. Bu nedenle, bölgelerin ekonomik ve sosyal açıdan gelişmişliğin sağlanması ve iç göçün sürdürülebilir bir şekilde yönetilmesi iç göç ve ekonomik büyüme arasındaki ilişkinin incelenmesini gerekli kılmaktadır. Bu çalışmada, Türkiye’ de Düzey-1 Bölgeleri (12 Bölge) arasında yaşanan iç göçün bölgelerin ekonomik büyümesine etkisinin analiz edilmesi amaçlanmaktadır. Bu amaç doğrultusunda, 2008-2020 dönemine Düzey-1 Bölgelerinde alınan- verilen göç ile ekonomik büyüme değişkenleri kullanılarak iç göçün ekonomik büyüme üzerindeki etkisi mekansal panel veri analiz yöntemleri kullanılarak analiz edilmektedir. Elde edilen ampirik bulgularda; alınan göç miktarı ile bölgenin ekonomik büyümesi arasında istatistiksel olarak anlamlı bir ilişki tespit edilememiştir. Ancak, verilen göç miktarındaki artışın bölgenin ekonomik büyümesini istatistiksel olarak negatif bir etkilediğini söylemek mümkündür. Verilen göç artışının bölge ekonomik büyümesi üzerindeki negatif etkilerinin azaltılması için üretim, istihdam, yatırım, eğitim, sağlık vb. göçe neden olan konularda bölge özelinde iyileştirici politikaların geliştirilmesi gerekmektedir.
2021 YKS yerleştirmelerinde Niğde Ömer Halisdemir Üniversitesi Siyaset Bilimi ve Uluslararası İlişkiler Bölümüne yerleşen öğrenci sayısındaki düşüşün nedenleri
Authors: TUTAN Melih Nadi , ÖZTÜRK Kübra , DÜĞEN Turgay
Published: July 2023

Türkiye’de üniversite yerleştirmeleri, özellikle bazı bölümlerde öğrenci sayısının düşüşüne tanıklık etmiştir. Niğde Ömer Halisdemir Üniversitesi (NÖHÜ), Siyaset Bilimi ve Uluslararası İlişkiler (SBUİ) bölümü de, bazı vakıf ve çoğu Anadolu’da yer alan devlet üniversitelerinin SBUİ bölümlerinde olduğu gibi bu olgudan etkilenmiştir. Bu bağlamda çalışmanın amacı; 2021 Yükseköğretim Kurumları Sınavı’nda (YKS) NÖHÜ SBUİ bölümünün tecrübe ettiği bu olgunun nedenlerini araştırmış olmakla birlikte, SBUİ öğrencilerinin üniversite tercihlerini şekillendiren olumlu ve/veya olumsuz motivasyonları açığa çıkararak çözüm önerilerinde bulunmaktır. Bu amaçla NÖHÜ, SBUİ bölümünün karakteristiklerini hem üniversite şehri hem taban başarı sıralaması açısından yansıtabileceği düşünülen ve 2021 YKS sonucunda 10’un üzerinde öğrencinin yerleşmiş olduğu üniversitelerin SBUİ bölümlerindeki, üniversitelerine ikamet ettikleri şehirden ayrılarak gelmiş 1. sınıf öğrencilerinden çalışma grubu oluşturularak yarı-yapılandırılmış mülakatlar ile veriler toplanmış ve nitel içerik analizi (qualitative content analysis) ile analiz edilmiştir. Çalışmanın sonucunda öğrencilerin şehir yakınlığı ve imajını, bölüm dersleri ve iş imkanlarını, aile ve sosyal çevre tavsiyelerini birincil olarak önemsedikleri, akademik kadroların yetkinliği ve yabancı dil gelişimi imkanlarını da diğer faktörler olarak gördükleri saptanmıştır.
İran bölge analizi: Toplum, kültür, ekonomi, politika, strateji ve uluslararası ilişkiler
Authors: ATEŞ ÇİFTÇİ Eylül Beyza
Published: July 2023

Küreselleşmenin etkileriyle beraber öne çıkan uluslararası siyaset, incelenecek ve araştırma yürütülecek alan çalışmalarının sayısını da arttırmıştır. Son 10-15 yıldır hem Türkiye’de hem de tüm dünyada oldukça fazla ilgi gören İran araştırmaları üzerine belirli konularda çokça detaylı çalışma yapılmış, merkezler kurulmuştur. Ortadoğu’nun önemli devletlerinden biri olan İran, 1979 İslam Devrimi sonrasında bölgesel ve uluslararası düzende adından çokça söz ettiren bir ülke haline dönüşmüştür. Tarihsel süreç içerisinde de pek çok imparatorluğa ev sahipliği yapan bir coğrafyaya sahip olması sebebiyle İran bugün halen bölgesel ve küresel güç mücadelelerinin değişim ve dönüşümüne etki eden konumda bulunmaktadır.
Formation of modern professional stereotypes of teachers as a condition for the formation of a resilient rural school
Authors: Ефремова-Шершукова Н. А. , Пивоварова А.В. , Сартакова Е.Е.
Published: July 2023

В статье обосновывается понятие резильентности, доказывается тезис о том, что степень резильентности школы обуславливается профессиональной деятельностью учителя, сформированными в педагогическом коллективе общепринятыми алгоритмами реализации конкретных трудовых функций, в том числе в области управления качеством образования на педагогическом уровне, взаимодействия с другими участниками образовательных отношений и участниками отношений в сфере образования. Приводится анализ результатов исследования уровня сформированности профессиональной компетентности учителей сельских школ, целью которого было выявить группы профессиональных стереотипов педагогической деятельности учителей сельских школ Томской области. Обосновывается связь научных понятий «резильентность» и «Профессиональные педагогические стереотипы», описываются основания для систематики стереотипов педагогов сельских школ.

The article substantiates the concept of resilience, proves the thesis that the degree of school resilience is determined by the professional activities of the teacher, the generally accepted algorithms for the implementation of specific labor functions, formed in the teaching staff, including in the field of education quality management at the pedagogical level, interaction with other participants in educational relations and participants in relations in the field of education. An analysis of the results of a study of the level of formation of professional competence of teachers in rural schools is given, the purpose of which was to identify groups of professional stereotypes of pedagogical activity of teachers in rural schools in the Tomsk region. The connection between the scientific concepts of "resilience" and "Professional pedagogical stereotypes" is substantiated, the grounds for the systematics of stereotypes of rural school teachers are described.
The model of formation of competence of social interaction in the conditions of distance learning in the Chinese audience of students
Authors: Иньчжоу П.
Published: July 2023

Педагогика в Китае имеет легендарное прошлое, насчитывающее тысячелетия. Конфуцианство долгое время было центральным элементом китайской педагогики с акцентом на чрезмерное образование и личностный рост. Кроме того, акцент был сделан на культивировании культурной утонченности и эстетической чувствительности. В настоящее время в китайской педагогике происходят изменения и развитие. Стремление к совершенствованию и реформе китайской образовательной структуры необходимо для того, чтобы идти в ногу с новыми требованиями и вызовами. Акцент на превосходной педагогике также имеет первостепенное значение, поскольку это может привести к повышению качества образования и способствовать развитию личности учащегося. Китай активно занимается научными исследованиями и новаторскими образовательными методами. Подготовка педагогических кадров является важнейшим компонентом китайской педагогики. В стране существует отточенная система профессионального образования, гарантирующая первоклассное обучение и развитие учащихся. Наряду с этим инновационные технологии произвели революцию в китайской педагогике и языковом образовании, особенно в русском. Следовательно, инновации китайской педагогики стали жизненно важными для прогресса в области образования и обучения в стране.

Pedagogy in China has a legendary past dating back thousands of years. Confucianism has long been a central element of Chinese pedagogy with an emphasis on excessive education and personal growth. In addition, emphasis was placed on cultivating cultural sophistication and aesthetic sensitivity. Currently, changes and development are taking place in Chinese pedagogy. Striving for improvement and reform of the Chinese educational structure is necessary in order to keep up with new requirements and challenges. The emphasis on excellent pedagogy is also of paramount importance, as it can lead to an improvement in the quality of education and contribute to the development of the student's personality. China is actively engaged in scientific research and innovative educational methods. The training of teaching staff is an essential component of Chinese pedagogy. There is a well-honed system of vocational education in the country, which guarantees first-class education and development of students. Along with this, innovative technologies have revolutionized Chinese pedagogy and language education, especially in Russian. Consequently, the innovations of Chinese pedagogy have become vital for the progress in education and training in the country.
Stratification, Segregation and Streaming within Schools
Authors: Ryan Thomas
Published: July 2023

Herein the culturally related human action of grouping people is examined as a phenomenon that has existing for many years in our global society. Today grouping people can be understood and labelled as stratification, segregation and streaming and can most readily be observed within schools and educational institutions. These grouping efforts and actions are addressed in related literature as sorting, tracking and categorization that may be at times tacit in classrooms and educational programs; nonetheless there are often life-long implications for streaming each student. Some education theorists may believe educators can sort students via assessment and evaluation of student academic ability however such attempts can be quite problematic, causing feelings of exclusion, marginalization and rejection. Academic ability is currently much more than a score on a summative assessment as academic ability has many social (home, community, engagement) and education elements (pre-school, instruction quality, class size, test bias). This iterative review illuminates issues, problems and concerns that may lead to possible resolutions for educators when grouping students.
SUPPLY AND DEMAND ANALYSIS OF BURUNG BATU BEACH TOURISM OBJECT IN SINGKAWANG, WEST KALIMANTAN
Authors: Erni Yuniarti , Indah Fitriani Meta , Iman Sumantri , B Soeryamassoeka S , R Hernovianty F
Published: July 2023

Singkawang City West Kalimantan Province has one of the natural attractions of the beach is Batu Burung Beach. The attraction of this object is the panorama of the beach with granite stones which is based on the history as the gathering place of birds. The attraction of Batu Burung Beach has not been the main destination for tourists, because it has not been developed properly and realized optimally. The factor that hinders the development of tourist attractions is marketing so that not many tourists know about the existence of this attraction. This research purposed to analyse the potential of supply and demand tourist attractions Batu Burung Beach. The research method used is quantitative method and supported by qualitative method. The analysis method that used to analyse potential supplies is ODTWA analysis, while to analyse potential demands is using descriptive analysis. The results of research on Batu Burung Beach attractions show that it is worth developing as a beach tourist destination. Based on the recapitulation of the value of potential objects and tourist attractions, the beach got a potential value index of 77.33% which falls into the category worth to be developed. The criteria that requires follow-up actions so that this object can be in priority scale and developed into a beach tourist attraction is marketing. While the potential demand criteria that require follow-up actions is the need for the expansion of tourist attraction areas, widening of the entrance, procurement of sign boards, the addition of shelters, the expansion of toilets and prayer rooms, the addition of food stalls, and the procurement of social media and information brochures. Batu Burung Beach tourism object with this handling is expected to be developed into an alternative beach tourist destination in Singkawang City.
THAN HOẠT TÍNH TỪ VỎ TRẤU: TỔNG HỢP, ĐẶC TRƯNG VÀ ỨNG DỤNG TRONG HẤP PHỤ Cr(III) VÀ Pb(II) TỪ DUNG DỊCH NƯỚC
Authors: Nguyễn Thanh Bình , Nguyễn Nho Dũng , Hà Công Văn , Trần Thanh Thảo , Hà Khánh Linh , Nguyễn Mậu Thành
Published: July 2023

Trong nghiên cứu này, chúng tôi đã điều chế than hoạt tính (AC) từ vỏ trấu bằng phương pháp hoạt hoá hoá học với NaOH và kết hợp với siêu âm. Sản phẩm được phân tích bằng phân tích nhiệt trọng lượng (TGA), nhiễu xạ tia X (XRD), hiển vi điện tử quét (SEM) và quang phổ phân tán năng lượng tia X (EDX). Quá trình hấp phụ – giải hấp phụ được sử dụng để xác định diện tích bề mặt (Brunauer – Emmett – Teller, BET). Vật liệu có cấu trúc carbon vô định hình; quá trình nhiệt phân vỏ trấu (than hoá) diễn ra ở khoảng 450 °C; vật liệu có cấu trúc xốp phát triển tốt với kích thước lỗ khác nhau; diện tích bề mặt tối đa khoảng 1673 m2·g–1 thu được từ mẫu kích hoạt bằng siêu âm trong 30 phút (AC30). Mô hình đẳng nhiệt Langmuir đã được áp dụng để mô tả đường đẳng nhiệt hấp phụ của các ion kim loại bằng AC30. Kết quả cho thấy AC30 là một chất hấp phụ tiềm năng để loại bỏ Cr(III) và Pb(II) từ dung dịch nước. Khả năng hấp phụ tối đa là 23,1 mg·g–1 đối với Cr(III) và 41,5 mg·g–1 đối với Pb(II).
TỔNG HỢP BẤT ĐỐI XỨNG CÁC DẪN XUẤT XÚC TÁC Ru(II)-DIALKYL-PHEOX TỪ CÁC DẪN XUẤT QUANG HOẠT (S)-2-AMINO-PHENYLETHANOL SỬ DỤNG TRONG PHẢN ỨNG TẠO VÒNG BA (CYCLOPROPANATION)
Authors: Lê Thị Loan Chi , Iwasa Seiji
Published: July 2023

Phát triển dược phẩm mới chứa đồng phân đối quang tinh khiết đang là một hướng mới của ngành công nghiệp dược thế giới trong những năm gần đây. Các chất xúc tác bất đối xứng đóng một vai trò không thể thiếu trong quá trình tổng hợp các sản phẩm đối quang tinh khiết. Chất xúc tác bất đối xứng Ru(II)-pheox đã được công bố có hiệu quả cho các phản ứng tạo ra các đồng phân đối quang tinh khiết. Trong nghiên cứu này, một quy trình tổng hợp bất đối xứng các dẫn xuất của Ru(II)-dialkyl-pheox được đề xuất. Quy trình bao gồm quá trình tổng hợp bất đối xứng các dẫn xuất oxazoline từ tiền chất và tạo phức giữa ruthenium và các phối tử oxazoline. Với quy trình này, bốn dẫn xuất bất đối xứng Ru(II)-dialkyl-pheox đã được tổng hợp thành công với hiệu suất cao (>60%).
Sample decomposition to determine microplastics in parts of mullets
Authors: Tran Thi Ai My , Phan Thi Thuy Hang , Tran Anh Tuan , Luong Quang Doc , Vo Van Quy
Published: July 2023

In this study, a 10% KOH solution was used to decompose the meat, skin, and digestive system of mullets. The factors in each experiment are as follows: 1) VKOH:mmeat is 10/1 (mL·g–1), incubated at 25 °C for 72 h; VKOH:mskin is 15/1 (mL·g–1), incubated at 40 °C for 72 h; VKOH:mdigestive system is 20/1 (mL·g–1), incubated at 40 °C for 72 h. The actual sample images display microplastics in the surveyed parts of the mullets with different shapes and colours.
ИЗЛУЧЕНИЕ, ВОЗНИКАЮЩЕЕ ПРИ ЗАХВАТЕ СВОБОДНОГО ЭЛЕКТРОНА В КАНАЛИРОВАННОЕ СОСТОЯНИЕ
Authors: Калашников Н. П. , Ольчак А. С.
Published: July 2023

При влете заряженной частицы в монокристалл происходит перестройка плоской волновой функции свободного электрона в суперпозицию локализованных волновых функций дискретных состояний движения в режиме каналирования.  Перестройка волновой функции электрона из свободного в каналированное состояние может произойти упруго, но может и сопровождаться квазихарактеристическим переходным электромагнитным излучением, возникающим на границе кристалла. Это переходное излучение дополняет хорошо известный тип излучения, возникающий в глубине кристалла при переходах каналированных частиц между дискретными состояниями квазисвязанного поперечного движения. Цель статьи – сравнение интенсивностей этих двух типов излучения.
International cooperation in the conditions of the NCTS joint transit system : in Ukrainian dimension
Authors: Fostolovych Valentyna , Mykhalchyshyna Larysa , Simanaviciene Zaneta
Published: July 2023

The purpose of the study was to determine the main aspects of simplifying conditions and creating prospects for international cooperation in terms of Ukraine's participation in the NCTS joint transit system. Examining the data of the State Customs Service of Ukraine and the State Statistics Service of Ukraine, the intensive work of the subjects of the regime of the joint transit system during the period of NCTS in Ukraine was noted. Confirm the need to simplify the conditions for the international movement of goods, analysis of the growth dynamics of Ukraine's foreign trade. According to the results of the research, it was revealed that by applying the provisions of the Convention, the prevention of fraud with accompanying documents is implemented, the security of international transportation is increased and uniform forms of customs control are recognized by all 36 participating countries.
After analyzing the benefits for the subjects of the customs regime, a decrease in the cost of customs procedures was noted; saving time on the duration of customs procedures; unloading checkpoints in queues; acceleration of the flow of trade in the international trade system.
The whole model of work in the NCTS system is an innovative approach and needed a lot of work and transformation of the work of both the State Customs Service of Ukraine itself and the regulation of regulatory support. The condition of mandatory financial guarantee and sealing of all movements became the basis for the development of a new mechanism for the implementation of these procedures that meet the requirements of the Convention. 
The practical application of the processed results is carried out in stages. To date, the implementation of appropriate IT solutions based on MASP-C is already being implemented. Gradually, the technology of administration of customs payments is being improved and the Customs Code of Ukraine is being brought into line with the Customs Code of the EU.
Clinical outcome of patients with diabetes mellitus infected by SARS-COV-2
Authors: Barros Nara Regina Batista , Mascarenhas André Neves , Barros Junior Francisco de Souza , Barros de Vasconcelos Beatriz , Sousa Tainá Maria Oliveira , Carvalho Ana RaquelBatista de
Published: July 2023

Introduction: Diabetes, a chronic metabolic disease with high prevalence in Brazil, is a risk factor for severe SARS COV-2 infection. The relationship between previous glycemic control and the prognosis of patients hospitalized with COVID-19 is not fully understood. Objective: analyze the clinical outcome of patients with diabetes mellitus infected by SARS-COV-2. Outlining: A retrospective analysis of medical records was carried out using the Trakcare electronic system of all diabetic patients hospitalized with a confirmatory diagnosis of pneumonia due to COVID-19 in the medical clinic ward of HRAN, from June to August 2021, who, upon admission, performed the glycated hemoglobin test and analyzed it using the SPSS software (20.0). Results: A sample of 52 patients was obtained during the study period. Most patients are female, with a mean age of approximately 58 years. The comorbidity most associated with the participants was systemic arterial hypertension, with most diabetics presenting good prior glycemic control, represented by HbA1c ≤ 7%. The lethality found was 7.7%. Implications: The study shows a high lethality of diabetic patients infected by COVID 19, but no statistical significance was found for HbA1c levels with the increase in length of stay, use of non-rebreathing mask, need for invasive mechanical ventilation or lethality
Factores de riesgo y complicaciones neurológicas en los pacientes con VIH/sida
Authors: Borja Santillán Maritza Alexandra , Coronel Reyes Axel Wladimir , Cobeña Carrillo Nicole Andreina
Published: July 2023

La infección por el VIH es una patología crónico-infecciosa trasmisible que produce la depleción continua y sostenida de linfocitos CD4, se la asocia a elevadas tasas de morbimortalidad. El presente trabajo de investigación se realizó en el “Hospital de Infectología José Daniel Rodríguez Maridueña” ubicado en la ciudad de Guayaquil en el periodo enero del 2019 a diciembre del 2021, cuyo objetivo fue determinar los factores de riesgo y las complicaciones neurológicas que más frecuentemente presentaron los pacientes con diagnóstico de VIH SIDA. La metodología del estudio es retrospectivo, descriptivo y transversal, con enfoque cuantitativo, diseño de investigación no experimental y correlacional. Se trabajó con 345 pacientes; 77.1% fueron varones, 28.4% tuvieron entre 25 -31 años, 78.3% secundaria, 96.2% de los casos fueron mestizos, 73.6% fueron de procedencia urbana, los niveles de cd4 fue de menos de 50 cel/mm3 en un 35,9%, la etiología parasitaria se presentó en 43.2% mientras que la micótica en 23.8%; la toxoplasmosis cerebral estuvo en el 42.3% de los pacientes, la criptococosis meníngea en 17.1% y la tuberculosis meníngea en 15.7%.
Regulación sanitaria y calidad en el laboratorio clínico, garantizando la precisión y seguridad de los resultados de diagnóstico
Authors: Hermosa López Angie Lisbeth , Villa Cedeño Katherine Pierina , Uribe Risco Valeria Alexandra , Marín Solorzano César Omar
Published: July 2023

Garantizar la seguridad y la atención del paciente es una de las principales razones por las que la calidad y la precisión de los resultados de laboratorio clínico son de suma importancia. Las medidas de garantía de calidad en los laboratorios clínicos tienen como objetivo minimizar los errores y garantizar que los pacientes reciban resultados de prueba precisos y confiables. Al adherirse a estrictos protocolos de control de calidad, los laboratorios pueden mejorar la atención al paciente y prevenir daños potenciales causados ​​por resultados incorrectos o engañosos. En consecuencia, el objetivo de la presente investigación consiste en plasmar aspectos fundamentales relacionados con la regulación sanitaria y el control de calidad en el laboratorio clínico, los cuales son aspectos garantes de la precisión y la seguridad de los resultados de diagnóstico. La investigación se realizó bajo una metodología de tipo documental bibliográfica, bajo la modalidad de revisión. En el laboratorio clínico es evidente la necesidad de contar con un sistema de gestión de la calidad y de competencia técnica, por cuanto es el lugar que da origen a la gran mayoría de las decisiones médicas. En ese sentido, resulta fundamental que los laboratorios clínicos, cumplan con toda la regulación sanitaria, ya sea internacional o nacional, obtengan sus certificaciones y acreditaciones; y de esta forma, contribuyan con la ciencia médica ofreciendo los mejores resultados de laboratorio.
Medicina interna en la era digital: innovaciones y avances en el diagnóstico de enfermedades sistémicas
Authors: Zambrano García José Carlos , Figueroa Moran Glenda Verónica , Salazar Escobar Jessica Fernanda , Espinoza Bone Maria José
Published: July 2023

La Medicina Interna, al igual que todo el sector sanitario, está al compás de los nuevos avances que está habiendo en el ámbito tecnológico. Las nuevas herramientas, dispositivos, terapias y modos de actuación van innovando, con un peso creciente de las nuevas tecnologías. El médico internista desempeña un papel fundamental en la atención de las enfermedades sistémicas, en donde pueden, especialmente, tener una visión integral del paciente. El diagnóstico temprano de cualquier de estas enfermedades aumenta la posibilidad de una intervención temprana y mejor pronóstico. En consecuencia, la presente investigación tiene el propósito de plasmar las generalidades de la revolución tecnológica en el sector salud y las innovaciones y avances en el diagnóstico de enfermedades sistémicas. La investigación se realizó bajo una metodología de tipo documental bibliográfica, bajo la modalidad de revisión. La introducción de técnicas de imagen avanzadas ha revolucionado el diagnóstico de enfermedades sistémicas, entre ellas la resonancia magnética (RM), la tomografía computarizada (TC) y la angiografía por resonancia magnética (ARM). Asimismo, el desarrollo del diagnóstico molecular también ha tenido un impacto significativo en el diagnóstico de enfermedades sistémicas. Por último, el uso de IA en imágenes médicas ha permitido una interpretación más precisa y eficiente de las imágenes médicas, lo que lleva a un diagnóstico y tratamiento más rápidos. Estos avances en el diagnóstico de las enfermedades sistémicas han permitido que se detecte la enfermedad más temprano, por ende, el inicio del tratamiento preciso de enfermedades sistémicas, lo que ha llevado a mejores resultados para los pacientes.
Optimalisasi Potensi Wisata Melalui Edusport Tourism di Telaga Ngrejek Gunung Kidul untuk Mewujudkan Desa Wisata
Authors: Santoso Nurhadi , Setyaningrum Ratna Kumala , Masri Masri , Wiyanto Agus
Published: July 2023

The purpose of this community service is to raise awareness among the community regarding the existing potential of Ngrejek Lake and to optimize the tourism management by the youth organization (karang taruna) and the community empowerment group (Pokdasawisma), through providing assistance in terms of Edu-Sport Tourism and promoting the "overflowing market" as part of the enchantment of the tourism that can be managed by the local residents. The implementation method involves delivering materials about community-based tourism (Pokdarwis) and Edu-Sport Tourism. The delivery pattern of the materials is more focused on presentation, discussion, and question and answer sessions, with the aim of developing Ngrejek Lake as a recreational area and Edu-Sport Tourism destination for the local community. The primary subjects of this target are the 23 members of the youth organization and the 7 village officials. Prior to the material delivery, a pretest is conducted, followed by a post-test after the implementation, specifically assessing the development of Ngrejek Lake as a recreational area and Edu-Sport Tourism destination. The pretest results show that the average understanding of the village officials regarding tourism village development is 49.43, and the average post-test result is 55.14. Similarly, the pretest results for the youth organization members show an average understanding of 51.35, with an average post-test result of 54.96. The comprehension of tourism village development has improved for both the village officials and the youth organization members in the efforts to develop Ngrejek Lake as a recreational area and Edu-Sport Tourism destination.ABSTRAKTujuan pengabdian ini adalah meningkatkan kesadaran masyarakat terhadap potensi yang ada di Telaga Ngrejek, serta untuk mengoptimalkan pengelolaan wisata oleh karang taruna dan Pokdasawisma dengan memberikan pendampingan mengenai Edu-Sport Tourism juga sosialisasi pasar tumpah sebagai bagian dari pesona wisata yang bisa dikelola olah warga. Metode pelaksanaan berupa penyampaian materi tentang Pokdarwis, dan Edu-Sport Tourism. Pola penyampaian materi lebih bersifat pemaparan materi, diskusi dan tanya jawab dalam pengembangan Telaga Ngrejek sebagai tempat rekreasi dan Edu-Sport Tourism bagi warga masyarakat. Subjek sasaran pertama ini karang taruna yang berjumlah 23 orang dan perangkat desa ada 7 orang. Sebelum pelaksanaan penyampaian materi dilakukan pretest dan sesudah pelaksanaan dilakukan postest tentang pengembangan Telaga Ngrejek untuk tempat rekreasi dan Edu-Sport Tourism. Hasil pretest pemahaman desa wisata pegawai perangkat desa dengan rerata 49,43 dan rerata postestnya 55,14. Sedangakan hasil pretest pemahaman desa wisata karang taruna dengan rerata 51.35 dan rerata postestnya 54.96. Pemahanan pengembangan desa wisata baik pegawai perangkat desa dan karang taruna meningkat dalam upaya pengembangan Telaga Ngrejek menjadi tempat rekerasi dan Edu-Sport Tourism.
Alih Kode dan Campur Kode dalam Saluran Youtube Tasya Farasya
Authors: Khofifah Nur , Ripai Ahmad , Utami H. R.
Published: July 2023

The purpose of this study is to describe the form and factors that influence the occurrence of code switching and code mixing. The method used in this study is a qualitative descriptive method. The data collection technique in this study is the free-of-talk (SBLC) listening technique. Presentation of data in descriptive form using ordinary words. The results of this study are the first, the type of code switching that occurs in Tasya Farasya's YouTube channel. Second, the types of code mixing that occur on Tasya Farasya's YouTube channel are divided into two, namely internal code mixing and external code mixing. Third, the factors that cause code switching include; ) speakers; (2) interlocutor; (3) limited language equivalents; (4) maintain prestige; and (5) the custom of a particular field. The factors that cause code mixing include (1) changing the topic of conversation (2) limited language equivalents; (3) speakers; (4) speech partners; and (5) maintain prestige. Circumstances based on the place and atmosphere as well as the object of the conversation change in various situations with the interlocutorKeywords: code switching, code mixing, speech eventsAbstrak Tujuan penelitian ini adalah mendeskripsikan wujud dan faktor yang mempengaruhi terjadinya alih kode dan campur kode. Metode yang digunakan dalam penelitian ini ialah metode deskriptif kualitatif. Teknik pengumpulan data pada penelitian ini ialah teknik simak bebas libat cakap (SBLC). Penyajian data dalam bentuk dekriptif dengan menggunakan kata-kata biasa. Hasil penelitian ini ialah pertama ialah, jenis alih kode yang terjadi dalam saluran YouTube Tasya Farasya. Kedua, jenis campur kode yang terjadi dalam saluran YouTube Tasya Farasya terbagi menjadi dua, yaitu campur kode ke dalam dan campur kode ke luar. Ketiga, faktor-faktor penyebab terjadinya alih kode meliputi; 1) penutur; (2) lawan tutur; (3) keterbatasan padanan bahasa; (4) menjaga gengsi; dan (5) kebiasaan bidang tertentu. Adapun faktor-faktor penyebab terjadinya campur kode meliputi (1) perubahan topik pembicaraan (2) keterbatasan padanan bahasa; (3) penutur; (4) mitra tutur; dan (5) menjaga gengsi. Keadaan yang didasarkan pada tempat dan suasana serta objek pembicaraan berubah dalam berbagai situasi dengan lawan tutur. Kata kunci: alih kode, campur kode, peristiwa tutur
Nilai-Nilai Pendidikan dalam Novel Nebula Karya Tere Liye sebagai Muatan Materi Belajar Sastra di SMA
Authors: Safiyah Mustika Arum , Umaya Nazla Maharani
Published: July 2023

The purpose of this study is to describe the educational values in Tere's novel Nebula. The collection method used in this study is a descriptive method with a qualitative approach. Qualitative approach that contains narrative not numbers. descriptive method is shown to describe the educational values in the novel Nebula by Tere Liye as a material for studying literature in high school. The results of the research in the novel Nebula by Tere Liye as a material for learning literature found several educational values, including the value of moral education with 35 data, social education value with 29 data, cultural education value with 14 data, and aesthetic education value with 6 data.ABSTRAKTujuan dari penelitian ini yaitu mendeskripsikan nilai nilai pendidikan dalam novel Nebula karya Tere. Metode pengumpulan daya yang digunakan dalam penelitian ini adalah  metode deskriptif dengan pendekatan kualitatif. Pendekatan kualitatif, yaitu berisi narasi bukan angka-angka. metode deskriptif ditunjukkan untuk mendeskripsikan nilai-nilai pendidikan dalam novel Nebula karya Tere Liye sebagai muatan materi belajar sastra di SMA. Hasil penelitian dalam novel Nebula karya Tere Liye sebagai muatan materi belajar sastra ditemukan beberapa nilai-nilai pendidikan, di antaranya adalah nilai pendidikan moral 35 data, nilai pendidikan sosial 29 data, nilai pendidikan budaya 14 data, dan nilai pendidikan estetika 6 data.