bluuebunny/crossref_metadata_2025 huggingface dataset:
Merged testing for colorectal cancer syndromes and re‐evaluation of genetic variants improve diagnostic yield: Results from a nationwide prospective cohort
Authors: Svensson Sara , Zagoras Theofanis , Aravidis Christos , Askmalm Marie Stenmark , Björck Erik , Borg Åke , Kuchinskaya Ekaterina , Nilbert Mef , Nordling Margareta , Rohlin Anna , Silander Gustav , Lagerstedt‐Robinson Kristina , Gebre‐Medhin Samuel
Published: April 2022

Approximately 5% of patients with colorectal cancer (CRC) have a Mendelian predisposition for the disease. Identification of the disease‐causing genetic variant enables carrier testing and tailored cancer prevention within affected families. To determine the panorama and genetic variation of Mendelian CRC syndromes among referrals at the cancer genetics clinics in Sweden, 850 patients clinically selected for CRC genetic investigation were included in a prospective study that tested for all major hereditary polyposis and nonpolyposis CRC conditions. Genetically defined syndromes were diagnosed in 11% of the patients. Lynch syndrome was predominant (n = 73) followed by familial adenomatous polyposis (n = 12) and MUTYH‐associated polyposis (n = 8); the latter of which two patients presented with CRC before polyposis was evident. One patient with a history of adolescent‐onset CRC and polyposis had biallelic disease‐causing variants diagnostic for constitutional mismatch repair deficiency syndrome. Post‐study review of detected variants of unknown clinical significance (n = 129) resulted in the reclassification of variants as likely benign (n = 59) or as diagnostic for Lynch syndrome (n = 2). Our results reveal the panorama of Mendelian CRC syndromes at the cancer genetics clinics in Sweden and show that unified testing for polyposis and nonpolyposis CRC conditions as well as regular reexamination of sequence data improve the diagnostic yield.
Simplification from tenofovir disoproxil fumarate plus lamivudine or emtricitabine plus ritonavir-boosted protease inhibitor to ritonavir-boosted atazanavir plus lamivudine in virologically suppressed HIV-infected adults with osteopenia: a pilot study
Authors: Blanco José L , Rojas Jhon , de Lazzari Elisa , Inciarte Alexy , Subirana Mar , Callau Pilar , Martinez-Rebollar María , Laguno Montserrat , Mallolas Josep , de la Mora Lorena , Torres Berta , Gonzalez-Cordón Ana , Martinez Esteban
Published: April 2022

Background

Tenofovir disoproxil fumarate, particularly when given with a ritonavir-boosted PI, reduces bone mineral density (BMD) and increases bone turnover markers (BTMs). Ritonavir-boosted atazanavir plus lamivudine is a feasible simplified option. We evaluated whether switching from a triple ritonavir-boosted PI plus tenofovir disoproxil fumarate to a two-drug regimen of lamivudine plus ritonavir-boosted atazanavir would improve BMD.

Methods

Single-arm pilot study. Virologically suppressed patients on tenofovir disoproxil fumarate plus lamivudine or emtricitabine plus ritonavir-boosted PI with low BMD, without previous resistance mutations and/or virological failure to study drugs were switched to 100/300 mg of ritonavir-boosted atazanavir plus 300 mg of lamivudine once daily. The primary endpoint was BMD change by DXA at Week 48.

Results

There were 31 patients, 4 (13%) female, and median age was 40 years. Seven participants (22.5%) had osteoporosis. At 48 weeks, mean (SD) changes in spine and hip BMD were +0.01 (0.03) (P = 0.0239) and +0.013 (0.03) g/cm2 (P = 0.0046), respectively. Mean (SD) T-score changes were +0.1 (0.23) (P = 0.0089) and +0.25 (0.76) (P = 0.0197), respectively. N-telopeptide and urine tenofovir disoproxil fumarate toxicity markers showed significant improvements. One participant withdrew from the study and two were lost to follow-up. There were no virological failures, or serious or grade 3–4 adverse events.

Conclusions

Switching from a tenofovir disoproxil fumarate plus ritonavir-boosted PI triple therapy to a lamivudine plus ritonavir-boosted atazanavir two-drug regimen in virologically suppressed HIV-infected adults with low BMD was safe, increased low BMD and reduced plasma markers of bone turnover and urine markers of tenofovir disoproxil fumarate toxicity over 48 weeks.
An ALS‐associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity
Authors: Nakano Juri , Chiba Kyoko , Niwa Shinsuke
Published: April 2022

KIF5A is a kinesin superfamily motor protein that transports various cargos in neurons. Mutations in Kif5a cause familial amyotrophic lateral sclerosis (ALS). These ALS mutations are in the intron of Kif5a and induce mis‐splicing of KIF5A mRNA, leading to splicing out of exon 27, which in human KIF5A encodes the cargo‐binding tail domain of KIF5A. Therefore, it has been suggested that ALS is caused by loss of function of KIF5A. However, the precise mechanisms regarding how mutations in KIF5A cause ALS remain unclear. Here, we show that an ALS‐associated mutant of KIF5A, KIF5A(Δexon27), is predisposed to form oligomers and aggregates in cultured mouse cell lines. Interestingly, purified KIF5A(Δexon27) oligomers showed more active movement on microtubules than wild‐type KIF5A in vitro. Purified KIF5A(∆exon27) was prone to form aggregates in vitro. Moreover, KIF5A(Δexon27)‐expressing Caenorhabditis elegans neurons showed morphological defects. These data collectively suggest that ALS‐associated mutations of KIF5A are toxic gain‐of‐function mutations rather than simple loss‐of‐function mutations.
Persistence Analysis of a Stochastic Single Species Population Model with Allee Effect
Authors: Xu Chaoqun , Li Guohua
Published: April 2022

This paper considers a stochastic single species population model with the Allee effect. We mainly analyze the persistence of population, and obtain the strictly critical conditions of persistence and extinction of population: When [Formula: see text], the population will go extinct in probability; when [Formula: see text], the stochastic model possesses a unique stationary distribution which implies that the population is permanent. The obtained results are finally verified through numerical simulations.
Bivariate Kumaraswamy Distribution Based on Conditional Hazard Functions: Properties and Application
Authors: Mohammed B. I. , Hossain Md. Moyazzem , Aldallal R. A. , Mohamed Mohamed S.
Published: April 2022

A new class of bivariate distributions is deduced by specifying its conditional hazard functions (hfs) which are Kumaraswamy distribution. The interest of this model is positively, negatively, or zero correlated. Properties and local measures of dependence of the bivariate Kumaraswamy conditional hazard (BKCH) distribution are studied. The estimation of type parameters is considered by used the maximum likelihood and pseudolikelihood of the new class. A simulation study was performed to inspect the bias and mean squared error of the maximum likelihood estimators. Finally, an application is obtained to clarify our results with the maximum likelihood and pseudolikelihood. Also, the results are used to compare BKCH distribution with bivariate exponential conditionals (BEC) and bivariate Lindley conditionals hazard (BLCH) distributions.
The compliance of nutrition claims on pita bread in Lebanon and risk on public health: a cross-sectional study
Authors: Bedran Priscilla , Bou-Mitri Christelle , Merhi Samar , Doumit Jacqueline , Fares Jessy El Hayek , Farhat Antoine G.
Published: April 2022

Background

Mislabeling is a type of fraud, that can lead to major health concerns, especially when used on staple foods like bread. This study aimed to assess the compliance of nutrition claims on pre-packaged Pita bread in Mount Lebanon with national (LIBNOR; NL 661:2017) and international (CODEX; CAC/GL -2–1985) standards.

Methods

A cross-sectional study was conducted and Lebanese bread samples (n = 75) were collected from all the registered bakeries in Mount Lebanon directorate (n = 25). The claim compliance assessment was based on values of the nutrition facts panel and standard nutrient analyses, following official methods.

Results

Of all assessed breads, 84% carried nutrition claims, and 25.3% carried health claims. Among nutrition claims, 70.7% had non-addition claims, 56.0% had nutrient content claims, and 1.3% had comparative claims. The results showed a high prevalence of nutrition claims with majority non-compliant. Based on the nutrition facts panel, only 32.4% of the sugar related claims, 45.5% of the fiber claims, and 54.4% of salt claims were eligible to make those statements. Based on the chemical nutrient analyses, only 47.0% of sugar claims, 16.1% of fiber claims, and 37.5% of salt claims were compliant. All the claims related to protein (n = 7) were compliant.

Conclusions

These results suggest the urgent need to develop clear guidelines for the effective implementation of the current standard; in order to prevent mislead consumers from making poor decisions at the point-of-sale, which might affect their overall health and efforts towards proper nutrition.
Angiographic analysis on posterior fossa hemorrhages and vascular malformations beyond aneurysms by CT angiography and digital subtraction angiography
Authors: Vignesh S. , Prasad Surya Nandan , Singh Vivek , Neyaz Zafar , Phadke R. V. , Mehrotra Anant , Mishra Prabhakar
Published: April 2022

Background

Posterior fossa malformations are less common than supratentorial malformations, but hemorrhages in posterior fossa are more serious due to presence of vital structures within this region. Most common cause of bleed in posterior fossa apart from hypertension is aneurysms but other vascular malformations are also there which cause hemorrhage. Here we discuss other causes of posterior fossa bleed beyond aneurysms.

Results

A total of 80 patients were evaluated: 47 (58.8%) had aneurysms, 29 (36.3%) had arteriovenous malformations, one each had developmental venous anomaly and brainstem cavernoma. Thirty vascular malformations were detected, of which 18 (62.1%) were pial arteriovenous malformations (AVMs), 11 (37.9%) were dural arteriovenous fistulas (dAVF), and one had developmental venous anomaly (DVA). Six patients of AVM underwent both DSA and CTA, and CTA could correctly diagnose only 2 of 4 pial AVMs detected by DSA. Among two dAVFs detected by DSA, CTA could demonstrate dAVF only in one patient.

Conclusion

CTA could be used as alternative to DSA in diagnosis and characterizing aneurysms in posterior fossa but for AVMs, 3D-CTA cannot replace DSA; however potential of time-resolved CTA (TR-CTA) appears promising.
Local Consistency Reinforcement for Enhancing Web Service Composition
Authors: AlQabasani Ahad , Hassine Ahlem Ben , Bramantoro Arif , AlMunchi Asma
Published: April 2022

Composing Web services to fulfill a user query remains one of the most challenging research problems due to its importance to the world economy. Several composition techniques have been proposed, but these techniques are becoming more and more expensive due to the tremendous growth of data over the internet, the intensive use of services, and the continuous changes of available services. The workflow-based Web service composition problem is an NP-complete problem, due mainly to the property of the workflow structuring the composition and the diversity of underlying constraints. Reinforcing local consistency is one of the well-known pre-processing techniques to reduce the complexity of most NP-complete problems. These techniques are mainly dedicated to binary constraint satisfaction problems. Therefore, only few researchers devoted their efforts toward reinforcing some level of local consistency on Web service composition problems that can be semantically defined in the Ontology Web Language for Web Services (OWL-S) control structure based constraints. The main goal of this paper is to propose a novel approach for reinforcing a reasonable level of local consistency, node and arc-consistency on any Web service composition problems. It is expected to provide a more up-to-date and realistic representation of any Web service composition problems without any user interactions, but with the ability to cope with any types of user’s query, such as incomplete, ambiguous, and others. This is due to the existence of several novel rules for reinforcing node and arc-consistency on all types of control structure constraints. Experiments were performed on random problems of different levels of complexity to evaluate the performance of the proposed approach.
Semantic Relation Extraction from Cultural Heritage Archives
Authors: Buranasing Watchira , Lilakiataskun Woraphon
Published: April 2022

Digital preservation technologies are now being increasingly adopted by cultural heritage organizations. This cultural heritage data is often disseminated in the form of digital text through a variety of channels such as Wikipedia, cultural heritage archives, etc. To acquire knowledge from digital data, the extraction technique becomes an important part. However, in the case of digital text, which has characteristics such as ambiguity, complex grammar structures such as the Thai language, and others, it makes it more challenging to extract information with a high level of accuracy. We thus propose a method for improving the performance of data extraction techniques based on word features, multiple instance learning, and unseen word mapping. Word features are used to improve the quality of word definition by concatenating parts of speech (POS) and word position is used to establish the accurate definition of a word and convert all of this into a vector. In addition, we use multiple instance learning to solve issues where words do not fully express the meaning of the triple. We also cluster the particular word to find the predicate word by removing words that are irrelevant between the subject and the object. The difficulty of having a new set of words that have never been trained before can be overcome by using unseen word mapping with sub-word and nearest neighbor word mapping. We conducted several experiments on a cultural heritage knowledge graph to show the efficacy of the proposed method. The results demonstrated that our proposed technique outperforms existing models currently utilized in relation to extraction systems. It can achieve excellent accuracy since its precision, recall, and F1 score are 0.89, 0.88, and 0.89, respectively. Furthermore, it also performed well in terms of unseen word prediction, precision, recall, and F1 score, which were 0.81, 0.87, and 0.84, respectively.
Death and life through the tourist’s gaze: Reflections on Gianfranco Rosi’s Boatman
Authors: Bollington Lucy
Published: April 2022

This article examines Gianfranco Rosi’s first documentary Boatman (1993) from the perspective of the touristic gaze deployed by the film in its portrayal of the sacred city of Benares, India, and the activities that take place there on the banks of the River Ganges, from washing to funerary rites. I situate the film in relation to persistent ethical questions regarding documentary encounters with death, arguing that Rosi’s self-reflexive alignment with – and interrogation of – several touristic gazes opens a set of primarily political concerns. These are elucidated in dialogue with the thought of philosopher Roberto Esposito on biopolitics and the ‘immunitarian’ paradigm. Through this lens, the documentary’s self-conscious adoption of touristic perspectives may be understood as revealing and challenging an exoticizing fantasy, animated by contagion and immunity, that frames Benares as a space exempt from the modern biopolitical impulse to protect the boundaries of individuals from the shared fabric of the commons.
Intimate disclosure: Below Sea Level and documentary humanism
Authors: Rhodes John David
Published: April 2022

Gianfranco Rosi’s mode of filmmaking apprehends the human ‘subject’ of documentary cinema in its uncertainty and unpredictability. Rosi’s cinema can be situated in the context of observational cinema, and like other filmmakers working in this vein, he focuses his camera on human subjects who we come to know across his films’ duration. In Below Sea Level (2009), Rosi focuses on the lives of people living marginal existences, on the edges of society, in a desert in southern California. These people disclose themselves (and are disclosed by Rosi’s shooting and editing) in an elliptical fashion that frustrates the desire for complete knowledge about their lives. In this method of intimate disclosure, in which there is a refusal to coax reassuring certainties from the people encountered in making this film, Rosi demonstrates the possibility of a humanist documentary cinema, insofar as ‘human’ in ‘humanist’ refers to an unpredictable becoming.
Acting across Borders: Mobility and Identity in Italian Cinema, Alberto Zambenedetti (2021)
Authors: Leavitt IV Charles L.
Published: April 2022

Review of: Acting across Borders: Mobility and Identity in Italian Cinema, Alberto Zambenedetti (2021)

Edinburgh: Edinburgh University Press, 256 pp.,

ISBN 978-1-47443-986-2, h/bk, $105.00
Mario Garbuglia luce sulla scena: Ricordi di cinema e teatro, Dani Massidda (ed.) (2021)
Authors: Keating Carla Mereu
Published: April 2022

Review of: Mario Garbuglia luce sulla scena: Ricordi di cinema e teatro, Dani Massidda (ed.) (2021)

Modena: Palombi Editori, 160 pp.,

ISBN 978-8-86060-916-8, p/bk, €15.00
Semi-fragile watermarking with recovery capabilities for HGI compression method
Authors:   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Bavrina A.Y. ,   Samara National Research University, Fedoseev V.A. ,   Samara National Research University,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS
Published: April 2022

The article proposes a new semi-fragile watermarking system with the ability of tamper localization and recovery after distortions, adapted for the HGI image compression method. The system uses a hierarchical image structure when embedding and replaces the stage of post-interpolation residuals quantization with a special quantizer based on quantization index modulation. As a result, the protected image becomes resistant to HGI compression with an adjustable quality parameter. The proposed watermarking system allows an image to be restored after distortions with an acceptable quality. In this case, the authentication part and the recovery part operate at different hierarchical levels. The developed watermark system, compatible with the HGI compression method, may be used to protect remote sensing images and medical images from malicious distortion.
Isolasi dan Identifikasi Escherichia coli Babi Penderita Porcine Respiratory Disease Complex Serta Uji Sensitivitas Terhadap Antibiotik
Authors: Pratanto Aditya , Suarjana I Gusti Ketut , Gelgel Ketut Tono Pasek
Published: April 2022

Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi Escherichia coli dari babi penderita Porcine Respiratory Disease Complex (PRDC) serta untuk mengetahui pola kepekaan E. coli terhadap kanamycin, doxycycline dan kotrimoksazol. Bakteri E. coli juga merupakan indikator resistensi antimikrob karena mampu menghasilkan Extended Spectrum Broad Lactamase (ESBL). Sampel dalam penelitian ini adalah swab nasal babi yang menunjukkan gejala klinis PRDC yang diambil sebanyak 21 sampel. Sampel diambil dari dua kabupaten di Bali yaitu Kabupaten Badung dan Kabupaten Tabanan. Isolasi E. coli dilakukan pada 21 media Eosin Methylene Blue Agar yang selanjutnya dikultur pada Sheep Blood Agar. Kemudian dilakukan dengan penegasan identifikasi bakteri melalui Pewarnaan Gram dan uji biokimia. Selanjutnya dilakukan uji sensitivitas E. coli terhadap kanamycin, doxycycline dan kotrimoksazol menggunakan metode modifikasi Kirby-Bauer dengan difusi cakram. Penelitian ini bersifat observasional dan data hasil penelitian yang diperoleh dianalisis secara deskriptif kualitatif. Hasil penelitian menunjukkan bahwa dari 21 isolat ditemukan empat (19%) isolat terdapat E. coli beta hemolitik. Hasil uji sensitivitas terhadap kanamycin empat isolat sensitif (100%). Uji sensitivitas terhadap doxycycline empat isolat resistan (100%). Uji sensitivitas terhadap kotrimoksazol satu isolat intermedier (25%) dan tiga isolat resistan (75%). Ditemukan E. coli ? hemolitik yang berpotensi patogen pada saluran pernapasan babi penderita PRDC dan isolat E. coli sensitif terhadap kanamycin dan resistan terhadap doxycycline dan kotrimoksazol.
Madu Trigona Mampu Menghambat Pertumbuhan Jamur Curvularia sp. yang Diisolasi dari Anjing
Authors: Patabang Denselina Lilis , Suartha I Nyoman , Sudipa Putu Henrywaesa
Published: April 2022

Curvularia sp. merupakan jamur dermatiaceae atau jamur dengan pigmen hitam yang menyebabkan berbagai macam penyakit pada hewan. Peningkatan invasi dan proliferasi jamur Curvularia sp. diakibatkan oleh penggunaan bahan kimia secara berlebihan. Oleh karena itu, dibutuhkan alternatif lain dalam mengobati penyakit jamur yaitu dengan obat herbal. Madu trigona mengandung senyawa flavonoid dan polyphenol karena lebah trigona dapat mengumpulkan nektar dari bagian bunga. Tujuan dari penelitian ini adalah untuk mengetahui tentang efektivitas madu trigona dalam menghambat pertumbuhan jamur Curvularia sp. Penelitian ini bersifat eksperimental menggunakan rancangan acak lengkap terhadap enam perlakuan yaitu madu trigona konsentrasi 20%, 25%, 30% dan 100%, kontrol positif dan kontrol negatif terhadap biakan jamur Curvularia sp. pada media Sabouraud Dextrose Agar. Madu trigona kemudian di uji sensitivitasnya dengan teknik lubang sumuran pada media Sabouraud Dextrose Agar dan dilihat hingga terbentuknya zona hambat. Terbentuknya hambatan di sekitar lubang sumuran yang tidak ditumbuhi jamur menunjukkan hasil positif dan zona hambat dapat diukur. Data kemudian dianalisis dengan menggunakan sidik ragam. Hasil dari penelitian menunjukkan bahwa madu trigona konsentrasi 20%, 25%, 30% dan kontrol negatif tidak menghasilkan zona hambat (0 mm). Madu trigona konsentrasi 100% menghasilkan zona hambat sebesar 2,14 mm, sedangkan kontrol positif menghasilkan zona hambat sebesar 5,15 mm. Madu trigona yang dapat menghambat pertumbuhan jamur Curvularia sp. yaitu madu dengan konsentrasi 100%.
Penambahan Tepung Belatung Lalat Black Soldier pada Pakan Meningkatkan Persentase Punggung dan Tidak untuk Karkas dan Recahan Karkas Ayam Pedaging
Authors: Paraningtyas Alya Diasti , Sulabda I Nyoman , Sumadi I Ketut
Published: April 2022

Tepung belatung/maggot telah banyak digunakan sebagai bahan substitusi pakan ternak, karena dapat menggantikan tepung ikan. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan tepung belatung/maggot black soldier fly pada pakan komersial terhadap persentase karkas dan recahan karkas pada ayam pedaging. Sebanyak 24 ekor ayam pedaging berumur satu hari atau day old chick/DOC dibagi empat perlakuan, masing-masing mendapat perlakuan P0 (tanpa tepung belatung/maggot), P1 (1% tepung belatung/maggot), P2 (2% tepung belatung/maggot), dan P3 (3% tepung belatung/maggot). Pakan perlakuan diberikan mulai hari ke-14 sampai hari ke-35. Hasil menunjukkan bahwa persentase karkas 75,43% sampai 77,78%, persentase dada 35,69% sampai 37,45%, persentase paha 30,73% sampai 32,02%, persentase sayap 10,41% sampai 10,74%, dan persentase punggung 17,44% sampai 19,44%. Uji statistika menunjukkan bahwa tidak ada perbedaan yang nyata antar perlakuan. Disimpulkan bahwa penambahan tepung belatung/maggot ke dalam ransum komersial tidak berpengaruh terhadap persentase bobot karkas, bobot dada, bobot paha, dan bobot sayap kecuali persentase bobot punggung.
Kadar Glukosa Darah Sapi Bali Jantan Pascatransportasi ke Rumah Potong Hewan Pesanggaran Denpasar
Authors: Dewi Ni Luh Putu Yunita Listiana , Sulabda I Nyoman , Dharmawan Nyoman Sadra
Published: April 2022

Kegiatan transportasi umumnya dapat mengakibatkan stres sehingga memengaruhi perubahan fisiologis pada ternak termasuk kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui kadar glukosa darah sapi bali pascatransportasi. Sampel darah diambil dari sapi bali yang baru datang setelah transportasi. Pengambilan sampel darah dilakukan dengan menggunakan venoject dengan jarum berukuran 21G pada vena jugularis dari 20 ekor sapi bali jantan di Rumah Potong Hewan Pesanggaran Denpasar. Darah yang telah diambil ditampung dalam tabung berisi antikoagulan Ethylene Diamine Tetraacetic Acid (EDTA), lalu dihomogenkan dan disimpan dalam coolbox. Pengujian sampel langsung dilakukan dengan menggunakan glukometer Nesco Multicheck 1. Pemeriksaan dilakukan sebanyak tiga kali untuk memperoleh rata-rata kadar glukosa darah pada setiap ekor sapi, data yang diperoleh kemudian dianalisis secara deskriptif, dan hasilnya disajikan dalam bentuk range dan simpangan baku. Hasil penelitian menunjukkan bahwa kadar glukosa darah sapi bali jantan pascatransportasi di RPH Pesanggaran Denpasar adalah 50,67 mg/dL ± 13,25. Hasil tersebut lebih rendah bila dibandingkan dengan data kisaran kadar glukosa darah sapi bali jantan yang ada yaitu dengan kadar 68,96-72,81 mg/dL. Rendahnya hasil tersebut dapat disebabkan oleh proses transportasi yang dilakukan.
Bakteri Klebsiella sp. Asal Babi Penderita Porcine Respiratory Disease Complex Resistan Terhadap Ampicillin dan Peka Sulfamethoxazole-Trimethoprim dan Kanamycin
Authors: Nazara Agustina Lesmauli , Suarjana I Gusti Ketut , Gelgel Ketut Tono Pasek
Published: April 2022

Penelitian ini dilakukan untuk mengetahui bagaimana pola kepekaan bakteri Klebsiella sp. asal babi penderita Penyakit Respirasi Kompleks pada Babi atau Porcine Respiratory Disease Complex (PRDC) terhadap antibiotik ampicillin, sulfamethoxazole-trimethoprim dan kanamycin. PRDC adalah penyakit saluran pernapasan pada babi yang disebabkan oleh multimikrob, salah satunya adalah bakteri Klebsiella sp. Klebsiella sp. merupakan bakteri Gram negatif yang mempunyai kemampuan memproduksi enzim Extended Spectrum Beta Lactamase (ESBL) yang menyebabkan resistansi terhadap antibiotik golongan beta-lactam. Penelitian ini menggunakan sampel isolat bakteri Klebsiella sp. bersifat ? hemolitik sebanyak tiga sampel yang telah diisolasi dan diidentifikasi secara konvensional dengan uji primer dan uji biokimiawi. Metode yang digunakan adalah metode difusi cakram menurut Kirby-Bauer dengan membuat suspensi bakteri yang kekeruhannya sesuai standar McFarland 0,5. Kemudian dilanjutkan dengan mengukur diameter killing zone (mm) yang terbentuk pada masing-masing paper disc. Data yang diperoleh dianalisis secara deskriptif dan disesuaikan dengan tabel standar diameter killing zone masing-masing antibiotik. Pola kepekaan yakni resistan, intermediet, dan sensitif disajikan dalam tabel persentase. Hasil yang diperoleh dari tiga sampel Klebsiella sp. menunjukkan yakni ketiga sampel resistan terhadap ampicillin 100%, terhadap sulfamethoxazole-trimethoprim sensitif 100%, dan terhadap kanamycin sensitif 100%. Klebsiella sp. resistan terhadap ampicillin, dan ketiga sampel sensitif terhadap sulfamethoxazole-trimethoprim dan kanamycin.
Bakteri Escherichia coli pada Limbah Peternakan Babi di Kabupaten Badung Jauh Melampaui Baku Mutu Coliform Provinsi Bali
Authors: Sousa Rojelio Dias Trindade , Suada I Ketut , Suarjana I Gusti Ketut
Published: April 2022

Peternakan babi merupakan salah satu usaha yang potensial untuk dikembangkan sebagai komoditas ekspor, sumber protein, dan sumber pendapatan keluarga. Limbah babi berasal dari campuran sisa-sisa pakan, minuman, urin, feses, serta air cucian bekas memandikan babi. Limbah babi yang mengandung bakteri E. coli menyebabkan pencemaran terhadap lingkungan di sekitarnya. Tujuan penelitian ini untuk mengetahui jumlah bakteri E. coli yang terdapat pada limbah peternakan babi di Kabupaten Badung, Provinsi Bali. Penelitian ini merupakan penelitian observasional dan pemilihan lokasi peternakan dilakukan secara purposive sampling. Lokasi pengambilan sampel di kecamatan Petang, Abiansemal, Mengwi dan Kuta Utara. Jumlah peternakan yang menjadi sampling di setiap kecamatan adalah sebanyak tiga peternakan. Volume sampel limbah yang diambil disetiap peternakan sebanyak 500 mL, selanjutnya dari tiga peternakan tersebut dilakukan komposit menjadi satu sampel. Media yang digunakan untuk menumbuhkan bakteri E. coli adalah media Eosin Metilene Blue Agar (EMBA). Sampel yang ditumbuhkan dalam media EMBA di setiap kecamatan sebanyak 0,1 mL dengan menggunakan metode sebar (spread plate method). Analisis data dalam penelitian ini dilakukan secara deskriptif kualitatif. Hasil penelitian menujukkan bahwa terdapat bakteri E. coli dalam limbah peternakan babi di Kecamatan Petang sebesar 90 x 107CFU/mL, Abiansemal 33 x 107 CFU/mL, Mengwi 11 x 107 CFU/mL dan Kuta Utara 9 x 107 CFU/mL. Dapat disimpulkan bahwa limbah peternakan babi di Kecamatan Petang, Abiansemal, Mengwi, dan Kuta Utara Kabupaten Badung, Propinsi Bali mengandung bakteri E. coli yang jumlahnya melebihi standar baku mutu.
Strategi Komunikasi Persuasif OJESA (Ojek Sahabat Wanita) Palembang dalam Meningkatkan Loyalitas Konsumen di Era Pandemi Covid-19
Authors: Hamandia Muhammad Randicha , Santi Eka Dian Novita
Published: April 2022

Penelitian ini berjudul “Strategi Komunikasi Persuasif Ojesa (Ojek Sahabat Wanita) Palembang Dalam Meningkatkan Loyalitas Konsumen Di Era Pandemi Covid19”. Strategi komunikasi persuasif adalah suatu proses perencanaan untuk mempengaruhi pendapat, sikap dan tindakan komunikan menggunakan manipulasi psikologis sehingga komunikan tersebut bertindak seolah keinginannya sendiri. Teori yang digunakan dalam penelitian ini adalah theory of reasoned action (Teori tindakan beralasan). Tujuan yang hendak dicapai dalam penelitian ini adalah untuk mengetahui bagaimana strategi komunikasi persuasif Ojesa dalam meningkatkan loyalitas konsumen di era pandemi Covid-19 dan untuk mengetahui apasaja faktor penghambat dan pendukung komunikasi persuasif Ojesa dalam meningkatkan loyalitas konsumen di era pandemi Covid-19. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif yang mendapatkan informasi melalui teknik pengumpulan data observasi, wawancara, dan dokumentasi. Hasil dari penelitian ini dapat dilihat dari customer yang merasa senang, nyaman, dan puas dalam menggunakan Ojesa. Strategi tersebut sangat efeketif dalam mengubah pendapat, sikap dan tindakan konsumen Ojesa. Dengan adanya strategi komunikasi persuasif berupa tindakan beralasan, maka tidak hanya Ojesa yang mendapat loyalitas konsumen, tetapi konsumen Ojesa juga merasa Ojesa memberikan pelayanan yang lebih dari nyaman kepada konsumen.
Exploring Resident Physician Wellness at an Allopathic Medical School in West Virginia: A Qualitative Study
Authors: Sedney, MD, MA Cara , Dekeseredy, MScN, RN Patricia , Elmo Rebecca , Sofka, MD Sarah
Published: April 2022

Introduction Social support is key to wellness, especially during times of stress and uncertainty. The working climate, including the multidisciplinary medical community, provides both positive and negative wellness experiences. The purpose of this study is to explore residents' concepts of wellness and the influence of programs, faculty, peers, and nursing and ancillary staff. Methods An email with a link to the REDCap survey was sent to each resident (n=450) in the medical school at West Virginia University, asking them to give examples of ways their wellness has been supported (or not) by faculty members, their program, co-residents, and nursing and ancillary staff. The residents returned 51 completed surveys (11% response rate). Seven residents participated in a face to face interview. A content analysis using Hale's adaptation of resident wellness (based upon Maslow's Hierarchy of Needs) as the theoretical framework was conducted on the data. Results Positive wellness elements frequently focused on time, supportive actions, and social connection. Negative examples impacting wellness included feeling disrespected, not being included in decision making, conflicts, and feeling unappreciated. Suggestions from the residents often described low-cost interventions such as being included and feeling part of the team. Conclusion The participants described how all healthcare team members could support resident wellness in various domains. Peers, support staff in the hospital environment, faculty supervisors, and the overall program can contribute to the basic physiologic needs, safety, belonging, esteem, and self-actualization of resident learners through social support.
Molecular diversity estimates of Pakistani citrus rootstocks
Authors: Noreen Ammara
Published: April 2022

Quality rootstocks are mandatory to fortify and boost up the citrus industry. Traditionally, Pakistani citrus industry is based on two rootstocks (rough lemon and sour orange), and consequently facing many biotic and abiotic constraints. Characterization and evaluation of new rootstocks is also essential to expand the citrus genetic resources for better utilization and to improve future breeding programmes. In this study thirteen rootstocks were assessed based on twenty-five morphological traits (quantitative and qualitative) whereas genetic diversity was evaluated by using forty RAPD markers. Results manifested huge morphological diversity in Sachian Citromello, Citromello 1452, Yuma citrange and Benton rootstocks. Thirteen RAPD markers proved reliable and effective tool and showed significant amplification, producing a total of 286 fragments with 61.53% polymorphism. Moreover, RAPD markers showed the individuality of all the studied rootstocks and highlighted the similarities and dissimilarities among them. Findings of this study will provide basis for further investigations looking to the improvement of citrus rootstocks. Results are also valuable for future rootstock breeding programs, particularly in release of superior and trustworthy new rootstocks for Pakistani citrus industry. The combination of such kinds of morphological and molecular markers is highly powerful tool in accomplishing detailed analysis of Citrus phylogeny and origin.
A Novel Design for Low-Power, High Performance and Space Efficient Address Decoder for SRAM
Authors: Foziya Lone , Ojha Er. Ritesh Kumar
Published: April 2022

Abstract: We discover the optimum decoder structure for fast low-power SRAMS. The results are ideal when the decoder is designed as a binary tree without the precoder. We find that skewed circuits with self-resetting gates work well, and we explore some basic scaling algorithms for minimal delay and power in the SRAM data path. Signal oscillations on high capacitance nodes like bit lines and data lines are decreased, resulting in low power operation. Clocked voltage sense amplifiers are required for low sensing power, and accurate construction of their sense clock is required for high-speed operation. By restricting bit line and NO line swings, we examine tracking circuits to aid in the development of the sense clock and allow timed sense amplifiers. The tracking circuits successfully use a replica memory cell and a replica bit line to track the memory cell's delay throughout a wide variety of manufacturing and operating conditions. The results of two different prototypes' experiments are reported. Finally, we investigate the speed and power development trends of SRAMs as a function of size and technology, discovering that if the connection delay is negligible, the SRAM delay grows as the logarithm of its size. Wire delay becomes increasingly important for SRAMs after the fifth generation. The wire delay worsens as the process shrinks, requiring wire redesign to keep the wire delay proportionate to the gate delay. Hierarchical SRAM topologies provide enough of array space for fat Wires and may be used to control time. Throughout the procedure, the wire delay for 4Mb and smaller designs diminishes. Keywords: SRAMs, High Performance, Delay, Clock, Decoder
Face and Eye Detection for Interpreting Malpractices in Examination Hall
Authors: Patil Vaibhavi , Patil Sakshi , Ganjegi Krishna , Chandratre Pallavi
Published: April 2022

Abstract: One of the most difficult problems in computer vision is detecting faces and eyes. The purpose of this work is to give a review of the available literature on face and eye detection, as well as assessment of gaze. With the growing popularity of systems based on face and eye detection in a range of disciplines in recent years, academia and industry have paid close attention to this topic. Face and eye identification has been the subject of numerous investigations. Face and eye detection systems have made significant process despite numerous challenges such as varying illumination conditions, wearing glasses, having facial hair or moustache on the face, and varying orientation poses or occlusion of the face. We categorize face detection models and look at basic face detection methods in this paper. We categorize face detection models and look at basic face detection methos in this paper. Then we’ll go through eye detection and estimation techniques. Keywords: Image Processing, Face Detection, Eye Detection, Gaze Estimation
Fitverse: A Fitness Assistant Application using Flutter
Authors: Shetty Siddharth , Padyal Mehul , Tikam Gauresh , Patil Ashwini
Published: April 2022

Abstract: With reference to this document, it describes the process and components of the development of the project. A fitness schedule is any behavioral pattern that one often and regularly does, by and large automatically; and Fitverse- the fitness assistant application, is a tool that aids the user in their fitness journey by providing them with customized diet recommendations and workout schedules. It also monitors if and when you complete your desired diet and fitness targets and acts as a guide in one’s journey to achieve the aspired fitness goals. Turning good behaviors into habits makes them our default, automatic choices of action. This all but eliminates the willful effort required to repeat them. It aids users with their fitness journey by being the virtual fitness trainer. Fitverse is an android-based application built using Flutter that helps in achieving fitness goals and building concrete habits. The Prototype Model is used to develop this system along with iterative software development model. As for the software used to develop this system is Visual studio code and programming language used is Dart with Firebase as the database. This technology can transform the current daunting task to develop a fitness schedule or a habit and make it more efficient and easier. Keywords: Dart language, Flutter, Iterative Software Development Model, Prototype Model, Firebase
Ecological and Biophysical Characterization of a Reclaimed Forest over Degraded Land of Haryana: Learning from Conservation Strategies
Authors: Singh Dharmendra , Nanda Krishma , Arya S , Darshana *
Published: April 2022

Forests play an important role in land management and environmental
sustainability via their ecological and biophysical characteristics.
These characteristics were assessed in a reclaimed forest developed over
saline, barren wasteland well known as Saraswati Wildlife Sanctuary
(SWS) to understand its ecological development, future threats, and
potential environmental benefits. We computed tree community
characteristics such as density, basal area, diversity, and species
composition using a tree dataset from 36 plots of 0.1 ha. A total of
1,711 individuals of 8 families, 10 genera, and 12 species were
recorded. Myrtaceae, Fabaceae, and Moraceae families were found
dominating in the area. Prosopis juliflora showed the highest
(142.50) Importance Value Index (IVI). The tree density varied from 435
ha to 767 ha .
Shannon–Weiner Index (H’), Simpson’s Diversity Index, Margalef Index,
and Evenness Index, were recorded as 1.39, 0.68, 1.48, and 0.56
respectively. The average total biomass and carbon stock were estimated
to be 344.3 tonnes/ha and 161.8 tonnes/ha. The total biomass of forest
was 14,88,674 tons and carbon stock 6,99,677 tons in 2020. A total of
279 ha of forest blanks were identified using Sentinel-2 satellite data
showing the existing potential of afforestation. Observations indicated
that the system is of less diversity, early aged, and at
anthropogenic/pathogenic risk due to its evenness and monospecific
nature, and requires exhaustive mixed plantation with suitable species
over open/blank areas immediately. We learn that the strategic planning
of reclamation through afforestation in a semi-arid environment with
similar conditions must focus on a complex community.
An integrated approach to developing an anthrax-free model area in Bangladesh
Authors: Sarker Md Shahjahan , Shahid Md. Ahosanul Haque , Mahmud Md. Muket , Kabir Ajran , Rahman Md. Bahanur , 2 Md. Asaduzzaman Sarker , Parvin Ratna , Nazir KHM Nazmul Hussain
Published: April 2022

An integrated approach was sought to establish an anthrax-free model,
where there will be no anthrax in an anthrax-prone area of Bangladesh.
The integrated approach included regular vaccination, increased public
awareness, rapid confirmation, and prompt disposal, setting up an
effective surveillance system, developing an emergency prevention
system, enforcing regulations, and enhancing veterinary services’
collaboration. Before the research work, a study area reported anthrax
in cattle or humans almost every one or two years. The location remains
Jamtoil village in Kamarkhanda Upazila of Sirajganj district located
between 24°18’ and 24°27’ north latitudes and amidst 89°35’ and 89°42’
east longitudes. Numerous interventions that included both social and
laboratory work were implemented from 2017 to 2020. After rigorously
implementing the study works, it showed that most community members
(97.5%) were aware of the nature, occurrence, public health importance,
and management of the disease. The risky habits and attitudes of the
farmers toward the slaughtering of sick cattle reduced significantly
(<85%). Vaccination coverage expanded from 40 to 85%, and
the percentage of farmers who can presumptively diagnose anthrax by its
notable clinical findings has increased from 30% to 85%. A PCR-based
confirmation protocol was applied. Soil samples were collected to
examine the pathogenic spores of Bacillus anthracis, and
researchers developed a map so that the farmers in the area would be
more cautious about grazing their cattle. A steering committee was
formed with the administration, law enforcement agency, local
government, livestock, health department, and political elites. This
committee periodically reviewed the progress of research work. At the
beginning of the investigation, the score was 18, but after implementing
research interventions, it increased to 100 out of 120. The locals set
up a slaughterhouse in that region, and people slaughtered their animals
after examining their animals by qualified veterinarians. As a result of
all these works, the model area has been free of anthrax infection for
four years. The research finding concluded that the integrated approach
is an efficient, effective, and suitable method to establish an
anthrax-free model area where there will be no anthrax outbreak.
An Application of The PROMETHEE Method To Select The Best Response for Carbon Fibre Reinforced Plastic Drilling in Machining Operations
Authors: Oke Sunday Ayoola , Odusoro Salome Ifeoluwa
Published: April 2022

The manufacture of carbon fibre reinforced plastic (CFRP) composites from carbon fibres fused with epoxy matrix, deploying the hand layup method has raised considerable attention. Within this research domain, drilling with various tools such as coated and uncoated drills is of great significance. Unfortunately, the use of intuition and experience to select the best parameter in the drilling operation has been known to be less efficient, causing the inadequate distribution of drilling resources to actualize the effectiveness of drilling parameters. Energy wastages are also associated with the present practice of intuition in drilling process. In this study, a novel approach of PROMETHEE I and II are presented to avoid ineffectiveness in drilling resource distribution and select the best drilling operations parameters. The proposed method utilizes experimental data from the literature to verify the method's performance. This study helps in reducing waste due to the inadequate distribution of drilling operations sources. PROMETHEE analyses the drilling parameters of the CFRP composites using preference functions that map the differences among alternatives during machining judgments. Out of the six responses examined, the best response is exit delamination with a weight of 0.059, surface roughness with a weight of 0.031emerged as the second position, torque weighing 0.003 took the 3rd position while the last position is entry delamination, weighing -0.102.
The impact of coronavirus on mental health and welfare of the elderly
Authors: Papageorgiou Athina , Skitsou Alexandra , Charalambous George
Published: April 2022

Extreme distancing during quarantine and social isolation in periods of serious infections, such as COVID-19, affected society and the social life of the population worldwide, changing cultural habits while it was found to be associated with mental and social health problems such as depression and anxiety. It was found that the elderly is
the portion of the population that is at greater risk in the COVID-19 epidemic and if they get sick, they have a greater risk of dying. This group is particularly vulnerable to infections due to a weakened immune system, comorbidities, including respiratory diseases, hypertension, diabetes and coronary heart disease. The balance that has been accomplished in the past between age-related disorders and good quality of life and health is now under high pressure. It is therefore very important to protect the elderly and if isolation can reduce the transmission of the disease and save their lives, it should be implemented, in order to maintain their quality of life as much as possible.
Compliance with the instructions and recommendations of the WHO and other national, regional, international organizations can significantly reduce the risk of spreading the disease. This study examines the impact of the coronavirus pandemic on the elderly and how this disease has affected their mental health and well-being. Our goal is also to comprehend the factors associated with depressive symptoms in older people during the disease.
The Structure of Space and its Impact on Interplanetary Travel and Answers to Fundamental Cosmological Questions
Authors: Sobolewska Natalia Julia , Sobolewska Joanna Paulina , Sobolewski Marek Juliusz , Sobolewski Michał Amadeusz , Sobolewski Dariusz Stanisław
Published: April 2022

The article presents the far-reaching implications of the theory entitled "Theory of Space" (Sobolewski D. S., Theory of Space, 2016) (Sobolewski D. S., Theory of Space, 2017) (Sobolewski D. S., Theory of Space, 2022 - new unpublished edition) and of the publication "New Generations of Rocket Engines" (Sobolewska, Sobolewska, Sobolewski, Sobolewski, & Sobolewski, 2021). Among others, it presents the shape of curved space in E4 for selected planets of the solar system and the Sun, taking into account boundary hypersurfaces  and gravitational interactions. The existence of space tunnels was analysed and the perspective of new technologies enabling interplanetary travel was outlined. Furthermore, due to the revealed structure of space, cosmological issues including the existence of other Universes and possible effects of their interactions are addressed. The constant Gdańsk was also introduced GGdańsk which, together with the introduced equation, makes it possible to determine the maximum immersion depth of an astronomical object of mass M.