bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomarkers for the Diagnosis and Surveillance of Cancer
Authors: Thakur Sharad , Kapoor Payal , Dutta Rahul , Thakur Kshema
Published: September 2023

Cancer remains one of the leading causes of death worldwide. Cancer management has been a daunting task for both health professionals and patients throughout the journey. Screening of cancer at the right time/stage remains the most critical part of the riddle. Certain molecules that characterize cancer, known as ‘biomarkers,’ come out to be the most useful in this journey. The National Institute of Health defines a biomarker as “a characteristic used to measure and evaluate objectively normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention”. These have proven to be often easily available agents employing minimally invasive methods. Biomarkers have played crucial roles in screening, asymptomatic and early-stage detection, monitoring of the treatment therapy and eventual follow-up to check upon a probable re-lapse or metastasis. A cancer biomarker can be any of the biomolecules such as protein, DNA, RNA, proteoglycans, immunological compounds, salivary biomarkers and endogenous peptides. With the refinement in high-throughput techniques, the list of the types of biomolecules and the number of potential biomarkers is only increasing, with volatile organic compounds from the breath (breath biopsy) adding to the list. In this chapter, we shall put effort into reviewing this otherwise very vast topic. The chapter will outline various types of biomarkers, the journey so far with clinically approved cancer biomarkers, the challenges being faced, and conclude with future perspectives.
Animal Models used in Cancer Research: Role of Transgenic Animals
Authors: Palaq  , Singh Sumit , Diksha  , Sharma Sonali , Gupta Shallina
Published: September 2023

In spite of the existence of many chronic diseases, cancer is still one of the major distresses for public health and is also the second largest major concern of death. The data collected from the last 50 years of research showed that very few cancers are curable, and the fear factor related to this disease is still unaltered. Victorious bench-tobedside transformation of basic methodical findings about cancer into therapeutic involvements for patients relies on the appropriate selection of animal experimental models. Animal models play an important role in studying the genetics and biology of human cancers as well as the preclinical examination of various cancer therapeutics and cancer prevention. In this chapter, we will review the imperative animal models such as spontaneous tumour models, chemically induced tumour models, radiationinduced tumour models, etc., along with other animal models, such as porcine, canines, etc., used for immuno-oncological research. In addition, the role of transgenic animals in cancer research will also be discussed.
Stem Cell Models: Novel Experimental Approach for Testable Alternatives against Therapy-resistant Breast and Colon Cancer
Authors: Telang Nitin
Published: September 2023

Breast and colon cancer represent the leading causes of mortality in developed countries. The treatment options for these organ site cancers differ depending on the status of hormone/growth factor receptors in molecular subtypes that exhibit altered expression of oncogenes/tumor suppressor genes and growth factormediated molecular pathways. Conventional cytotoxic chemo-endocrine therapy traditionally includes the use of anthracyclin, taxol, cisplatin, anti-estrogens, antifolates and DNA anti-metabolites. Additionally, the use of molecular pathway-specific small molecule inhibitors represents evidence-based targeted therapy. Long-term conventional or targeted therapy using pharmacological agents is frequently associated with systemic toxicity, acquired tumor resistance and the emergence of drug-resistant cancer stem cells. These limitations are associated with the progression of the therapyresistant disease. Natural products such as dietary phytochemicals, their respective bioactive agents, botanicals, nutraceuticals and nutritional herbs are widely used in complementary and alternative medicine in women for estrogen-related issues, osteoporosis and breast diseases. Unlike conventional or targeted chemo-endocrine therapeutics, natural products, mainly due to their low systemic toxicity, may not lead to acquired tumor resistance and therefore, represent testable alternatives against therapy-resistant cancer. These aspects emphasize a need to develop reliable experimental approaches, and specific and sensitive biomarkers that facilitate the identification of effective testable alternatives against therapy-resistant cancer. Models for drug-resistant stem cells have been developed and characterized from the parental breast and colon carcinoma-derived cell lines, as well as from the cell lines derived from genetically predisposed colon cancer models. These stem cell models are characterized by the quantifiable expression status of select stem cell-specific cellular and molecular markers.Mechanistically distinct natural products have documented growth-inhibitory effects on parental cell lines. Some of these agents also exhibit stem cell targeted growth inhibitory efficacy. Recognizing clinical evidence for the role of estrogens in breast and colon cancer, future investigations include the development of tumor organoid models of therapyresistant breast and colon cancer from female patient-derived xenografts. These investigations support a scientifically robust rationale to provide clinical translatability for patient-derived preclinical data. This chapter summarizes the evidence relevant to experimental models systems, natural products and efficacy of lead compounds as stem cell-targeted testable alternatives against breast and colon cancer. Collectively, discussed evidence and its clinical relevance support the hypothesis that natural products may benefit patients that are diagnosed for therapy resistant cancers.
Nano-based Nutraceuticals and their Applications: Food Safety, Regulation and Challenges
Authors: Jayakar Varsha , Lokapur Vinayak , Shantaram Manjula
Published: September 2023

The growth of functional foods has gotten a lot of attention as people become more aware of the relationship between nutrition and human health. Several problems are identified, including discovering beneficial phytochemicals, establishing acceptable consumption levels, and producing suitable food delivery matrices and product compositions. Many nanotechnology-derived processes and materials have the potential to provide innovative solutions in many of those foreparts. Nanotechnology works with materials on the atomic and molecular levels to create structures smaller than 100 nanometers in one dimension. Food nanotechnology could be a comparatively recent area that has opened up an entire world of new applications in the food industry. The applications comprise better taste, color, flavor, texture, and consistency of foodstuffs, the bioavailability of nutraceuticals, increased absorption and health supplements, food antimicrobial developments, food packaging materials with better quality, mechanical barrier, and antimicrobial properties, nano-sensors for traceability and observing the condition of food during transport and storage, encapsulation of food constituents or additives. This chapter briefly reviews the role of nanotechnology in functional foods and its applications, and food safety, regulation, and challenges are discussed.
Corona als (gemiste) kans
Authors: Evers David , de Hollander Guus
Published: September 2023

Sinds het begin van de pandemie speculeren stadsgeografen, ruimtelijke economen en planologen over de mogelijke gevolgen voor steden. Zal corona een nieuwe periode van de-urbanisatie inluiden? Betekent dit het einde van files of het openbaar vervoer? Zijn er in de toekomst nog winkels in onze binnensteden of laten we alles via platforms bezorgen? Tegelijkertijd wordt er volop nagedacht over hoe deze crisis gebruikt kan worden om noodzakelijke hervormingen of zelfs transities te versnellen: corona als ‘kans’. Na een paar jaar hebben we meer zicht op wat er feitelijk is gebeurd. Wat voor beleid is daadwerkelijk gevoerd om de gevolgen van de pandemie te verzachten en zijn hierbij inderdaad ‘kansen gegrepen’? Op basis van recent ESPON-onderzoek worden de ervaringen in de regio Amsterdam besproken in het licht van de EU herstelfondsdoelstellingen om sociaaleconomische achterstanden te verminderen (just), de samenleving met respect voor de natuur duurzamer te maken (green) of slim verder te digitaliseren (smart). Op het oog lijkt hiervoor maar weinig aandacht te zijn geweest in Nederland. Dat komt deels door de vergaande centralisatie in Nederland en door het generieke karakter van het beleid om de negatieve gevolgen van corona te verzachten. Op lokaal niveau wordt echter wel degelijk aan deze transities gewerkt bij de crisisbestrijding, maar dan wel vaak ingepast in bestaande strategieën. Zo worden kansen (weliswaar wat verborgen) toch min of meer benut.
Regional peculiarities of the Zrubna/Timber-grave culture tribes’ calendar system
Authors: Zabavin Viachesiav , Nebrat Serhii
Published: September 2023

The article presents the results of the study on the burial of the Zrubna/Timber-Grave culture (Late Bronze Age) from the mound near the village of Komyshuvate in the North Azov Area in the south of Donetsk Region of Ukraine. The article deals with issues related to some peculiarities of the material and spiritual culture of the ancient population of the Azov steppes, their social organization and funeral rites. Ceramic vessels are the most common category of equipment in the funerary inventory of the Zrubna/Timber-grave culture graves. Finds of pottery with extraordinary ornaments, which researchers interpret as pictograms, proto-literacy, and plot drawings, have always been of particular interest. The calendar ornamentation on the pots of the Zrubna/Timber-grave culture deserves special attention. The pot with the ornamentation, which, according to the authors, was of a calendar nature, comes from burial 1 of barrow 4 of the Komyshuvate cemetery. A detailed analysis of the ornamentation on the pot from this burial allowed us to suggest that the cyclic composition depicted on the ceramic vessel records recurring time periods that were important to the ancient population. Perhaps the ornament also reflects the regional peculiarities of the calendar system of the Zrubna/Timber-grave culture tribes: annual and lunar cycles with the time of transition from the old to the new year.
Construction of regional myths: a case study of the Greeks of the North Azov Sea region
Authors: Arabadzhy Svitlana
Published: September 2023

The article examines the process of constructing the mythological image of the Russian Empire as a "saviour of Christians" who were resettled from the Crimean peninsula to the North Azov Sea region, which became the basis for the formation of a historical myth in the region. The paper uses the analysis of various sources: orders, letters, reports, rescripts, descriptive and statistical materials, messages, etc. to consider the main stages of creating and maintaining this image and its articulation at different levels. The author proves that the positioning of Russia's special mission to protect the Christian population of the peninsula began from the moment the Russian Empire decided to resettle Christians from the territory of the Crimean Khanate. The Russian Empire assumed a leading role in the protection of “co-religionists” justifying themselves by unbearable religious oppression and the difficult situation of the Greeks, Armenians, Georgians and all those who practiced Orthodox Christianity in a Muslim state. To strengthen its role and emphasize the importance of its “mission” the Russian Empire created and spread the image of the Crimean Khanate as a despotic state that oppressed the Christian population in every possible way and limited their religious and social rights almost to the point of destruction. Their extremely difficult situation forced the Crimean Christians to appeal to the Russian Empress to resettle them on the territory of the Orthodox Empire. This was the official version of the resettlement of the Christians used at all levels and became the basis for the construction of the myth.
The official image of the empire as the “savior” of the Christians was actively spread at first through the works of priests and representatives of the church. The special role of the leader of the Crimean Christians – Metropolitan Ignatius of Gotfey and Kafay was constructed. His actions are compared with the actions of the Old Testament Prophet Moses. In the second half of the 19th and early 20th centuries, this image was replicated by educators, doctors, and researchers of history. At this stage, the author observes the fixation of the official image of the Russian Empire as the “savior” of Christians. It was inconsistent with the memories of the Greeks and their descendants who survived the resettlement and strove to return to the Crimean Peninsula. At the same time, the “logical chain” of the regional myth about the founding of Mariupol by Metropolitan Ignatius and the first commemorative practices in his honor was built. All this laid the foundation for the final formation of the myth of the imperial city of Mariupol.
Dupuytrenova kontraktura - bolest Vikinga u suvremenom svijetu
Authors: Mitrović Vivien
Published: September 2023

Dupuytrenova kontraktura (DK) dobro je poznata, česta benigna fibromatoza dlana koju karakterizira kronična progresivna fibroza palmarne fascije s fleksijskim deformitetima prstiju. Ova idiopatska bolest poznata od doba Vikinga prisutna je u čak 8 % svjetske populacije, češća je u muškaraca te u njezinoj etiologiji bitnu ulogu igra naslijeđe koje pokazuje varijabilnu ekspresiju. Patogeneza DK još uvijek nije u potpunosti razjašnjena, a uključuje nastanak kolagenih čvorića koji progrediraju u fibrozne tračke na mjestima najvećeg pritiska između dermisa i fascije. Dijagnoza se najčešće lako ustanovi samim kliničkim pregledom, a liječenje može biti konzervativno i kirurško. Konzervativno liječenje preporučuje se kod pacijenata koji imaju simptome blažeg stupnja i nemaju kontrakture, dok kirurško liječenje ostaje zlatni standard te se provodi kod pacijenata koji zbog nastale kontrakture imaju limitiranu funkciju šake i/ili fleksiju proksimalnog interfalangealnog zgloba od ≥15 stupnjeva i/ili metakarpofalangealnog zgloba od ≥ 30 stupnjeva. Cilj ovog preglednog rada je prikazati najnovije spoznaje vezane za Dupuytrenovu bolest koje se temelje na rezultatima sustavnih pregleda i metaanaliza.
Ultrazvuk dijafragme i njegova primjena u kliničkoj praksi
Authors: Posavec Anja Ljilja , Huzjan Korunić Renata , Piskač Živković Nevenka
Published: September 2023

Ultrazvuk dijafragme dijagnostička je metoda kojom se može utvrditi dijafragmalna disfunkcija ili paraliza. Dijafragmalna disfunkcija može uzrokovati otežano disanje i intoleranciju napora. Rijetko se utvrđuje u kliničkoj praksi te prava incidencija nije poznata. Javlja se u nekih neuromišićnih bolesti poput multiple skleroze, amiotrofične lateralne skleroze, poliomijelitisa, lezije N. phrenicusa te u nekih bolesti vezivnog tkiva, plućnim bolestima ili idiopatski. Za razliku od ranije upotrebljavanih metoda procjene dijafragmalne funkcije poput elektromiografije, mjerenja transdijafragmalnog tlaka i fluoroskopije, ultrazvuk je neinvazivna i jednostavna pretraga koja ne izlaže bolesnike ionizirajućem zračenju. Cilj je ovog rada opisati pregled dijafragme ultrazvučnom metodom te primjenu ultrazvuka u kliničkoj praksi uz pregled literature.
Metal Pollution Index and Related Health Risks of Consumers of Lipsticks Available on the Market in the Republic of Croatia
Authors: Modrić Dora , Tomić Linšak Dijana , Glad Marin , Mežnarić Silvestar , Linšak Željko , Broznić Dalibor
Published: September 2023

Cilj: Budući da tragovi metala nisu deklarativno navedeni na kozmetičkim proizvodima, posebice ruževima za usne, nameće se potreba za utvrđivanjem njihove prisutnosti i analizom toksikoloških učinaka. Ovim istraživanjem analizirala se prisutnost i raspodjela metala Cr, Cd, Ni, Pb te Cu i Zn u ruževima za usne. Materijali i metode: Analizirano je 100 uzoraka ruževa za usne različitih proizvođača ovisno o zemlji proizvodnje (Europska unija - EU, Kina, Ujedinjeno Kraljevstvo – UK i nepoznato podrijetlo). Udjeli metala određeni su analitičkom tehnikom ICP-MS. Rezultati: Rezultati skupnih podataka ukazuju na dominaciju Pb u opterećenosti metalima (indeks IOM) uzoraka ruževa za usne, kod uzoraka proizvođača EU-a dominira utjecaj Pb i Zn, dok kod proizvođača s područja Kine najjači utjecaj na IOM ima Cr. Predloženi linearni prediktivni model ukazuje na to da u skupnim uzorcima i onima s različitih područja dominaciju ostvaruje Cd, iako i Pb ima znatnu ulogu kao opterećujući metal. Ni je prisutan kao toksikant u svim uzorcima osim onih s područja Kine, dok Cr znatnu ulogu ima jedino kod proizvođača iz EU-a. Uspoređujući sa zakonskom regulativom, udjeli analiziranih metala niži su od utvrđenih maksimalno dopuštenih koncentracija (MDK) za pojedine metale, osim uzoraka proizvođača s područja Kine gdje je detektiran viši udio Ni od propisanih vrijednosti MDK. Zaključci: Rezultati studije pokazuju da, bez obzira na sadržaj toksičnih metala u kozmetičkim proizvodima, treba obratiti pažnju na dugoročan period njihove primjene te slab indeks eliminacije iz organizma. Poradi sigurnosti primjene kozmetičkih proizvoda nameće se potreba za kontinuiranim praćenjem opterećenosti teškim metalima, kao i redovitom kontrolom generiranih zdravstvenih rizika pri uporabi takvih proizvoda.
Najčešći razlozi odbijanja dobrovoljnih darivatelja krvi Hrvatskog zavoda za transfuzijsku medicinu u Zagrebu i Kliničkog zavoda za transfuzijsku medicinu u Osijeku tijekom 2021. godine
Authors: Rebrina Matea , Halilović Edin
Published: September 2023

Cilj: Prikazati najčešće razloge odbijanja potencijalnih darivatelja krvi po spolu i usporediti ih između gradova Osijeka i Zagreba. Ispitanici i metode: Istraživanje je provedeno po principu retrospektivne studije tijekom 2021. godine iz baze podataka Hrvatskog zavoda za transfuzijsku medicinu u Zagrebu i Kliničkom zavodu za transfuzijsku medicinu u Osijeku. Korišten je χ2-test, dok je statistička analiza napravljena pomoću programskog sustava MedCalc (inačica 14.12.0, MedCalcSoftware) uz razinu značajnosti od P < 0,05. Rezultati: Hrvatski zavod za transfuzijsku medicinu u Zagrebu kao najčešći razlog odbijanja potencijalnih darivatelja krvi navodi sniženu koncentraciju hemoglobina zbog koje je odbijeno 7 119, od kojih 2 583 (36 %) muškarca i 4 536 (64 %) žena. Također, Klinički zavod za transfuzijsku medicinu u Osijeku odbio je najviše potencijalnih darivatelja krvi zbog snižene koncentracije hemoglobina, njih 660, od kojih 235 (36 %) muškaraca i 425 (64 %) žena. Nakon obrade podataka nema statistički značajne razlike u odbijanju potencijalnih darivatelja krvi zbog hemoglobina u Zagrebu i Osijeku uspoređujući ih po spolu (P = 0,729). Zbog krvnog tlaka odbijenih potencijalnih darivatelja krvi u Zagrebu bilo je 3 855, 2 375 (62 %) muškaraca i 1 480 (38 %) žena. Odbijenih potencijalnih darivatelja krvi zbog krvnog tlaka u Osijeku je bilo 369, 141 (38 %) muškarac i 228 (62 %) žena. Statistički značajna razlika u odbijanju potencijalnih darivatelja krvi zbog krvnog tlaka u gradovima po spolu postoji (P < 0,001). Zaključak: Najčešći razlozi odbijanja dobrovoljnih darivatelja krvi tijekom 2021. godini u Hrvatskom zavodu za transfuzijsku medicinu u Zagrebu i Kliničkom zavodu za transfuzijsku medicinu u Osijeku jesu snižena koncentracija hemoglobina te krvni tlak kod obaju spolova.
Distress Scores During Radiotherapy for Lung Cancer: Course and Prognostic Factors
Authors: RADES DIRK , DELIKANLI CANSU , JANSSEN STEFAN , BOHNET SABINE , YU NATHAN Y.
Published: September 2023

Background/Aim: Cancer treatment can lead to significant distress. We investigated the course of distress during radiotherapy (RT) for lung cancer. Patients and Methods: Data of 159 patients receiving RT for lung cancer were investigated for change of distress scores during RT. Five characteristics were analyzed including age, sex, Karnofsky performance score, intent of RT, and receipt of previous RT. Additional analyses were performed in patients with pre-RT scores ≤5 points. Results: Mean pre-RT and post-RT distress scores were 5.5 (±2.6) and 4.7 (±2.6), respectively. No characteristic was significantly associated with mean change or increase of distress. In patients with pre-RT scores ≤5 points, non-significantly higher rates of increased distress were found for age ≤64 years, female sex, and Karnofsky performance score 90-100. Conclusion: Distress is reduced during a course of RT for lung cancer. This may reflect a reduction in anticipatory distress after first-hand experience.
Effect of different types and levels of phosphorous fertilizers on kinetics of phosphorous release in the soil
Authors: H. Habeeb Kahraman , Hasan Odhafa Abdul Kareem , Kareem Hashim H.
Published: September 2023

A field experiment was carried out in one of the fields of Diwaniya
governorate for the agricultural season 2019 to study the effect of adding organic
fertilizer and sources of phosphate fertilizer during the growth stages of the maize
plant (Zea mays. L) and its reflectance on growth and productivity of the plant.
The experiment was conducted according to the design of the (split-split plots
and included two levels of the organic fertilizer(L1-L0) standing for (0- 1.5 tons)
and three sources of the following fertilizers: Tri super phosphate TSP, DiAmmonium phosphate DAP and Urea UP) as add to control treatment (p0) symbolized by p1, p2, p3, respectively. The seeds of maize (Zea mays. L) Behoth
5018s cultivar were planted in a 25 kg/H range. The kinetics of phosphorous in
the soil were studied. The phosphorus release rate was determined during the
stages of plant growth, and the best equation in describing the mechanism of desorption in the stages of plant growth (25, 50, 75, 100 and 125 days). The results
showed that all used equations (first-order, diffusion and Elovich) have described
the mechanism of phosphorous release from a solid phase to the soil solution. All
equations gave a highly significant correlation (r) between released phosphorous
in the stages of Plant growth. The first-order equation surpassed other equations
describing the mechanism of phosphorous release in the soil. The values of the
coefficient of phosphorous release rate (KP) ranged between (0.0045 - 0.004 mg.
p. kg-1
. Day-1
) for the equation of first- -order, where the results showed that the
linear relationship between the amount of released phosphorous as a function of
time for the equation of first-order, is the best equation in describing the release,
which indicates the interest in the amount and timing of addition of p fertilizers
during the stages of plant growth, according to what was shown in the kinetic
equations.
Keywords: Phosphorous desorption, fertilizers, maize, kinetic equations, soil solution.
Home-Based Connected Devices Combined With Statistical Process Control for the Early Detection of Respiratory Exacerbations by Patients With Cystic Fibrosis: Pilot Interventional Study With a Pre-Post Design (Preprint)
Authors: Le Roux Enora , Ursino Moreno , Milovanovic Ivana , Picq Paul , Haignere Jeremie , Rault Gilles , Pougheon Bertrand Dominique , Alberti Corinne
Published: September 2023

BACKGROUND

Currently, patients with cystic fibrosis do not routinely monitor their respiratory function at home.

OBJECTIVE

This study aims to assess the clinical validity of using different connected health devices at home to measure 5 physiological parameters to help prevent exacerbations on a personalized basis from the perspective of patient empowerment.

METHODS

A multicenter interventional pilot study including 36 patients was conducted. Statistical process control—the cumulative sum control chart (CUSUM)—was used with connected health device measures with the objective of sending patients alerts at a relevant time in order to identify their individual risk of exacerbations. Associated patient education was delivered. Quantitative and qualitative data were collected.

RESULTS

One-half (18/36) of the patients completed the protocol through the end of the study. During the 12-month intervention, 6162 measures were collected with connected health devices, 387 alerts were sent, and 33 exacerbations were reported. The precision of alerts to detect exacerbations was weak for all parameters, which may be partly related to the low compliance of patients with the measurements. However, a decrease in the median number of exacerbations from 12 months before the study to after the 12-month intervention was observed for patients.

CONCLUSIONS

The use of connected health devices associated with statistical process control showed that it was not acceptable for all patients, especially because of the burden related to measurements. However, the results suggest that it may be promising, after adaptations, for early identification and better management of exacerbations.

CLINICALTRIAL

ClinicalTrials.gov NCT03304028; https://clinicaltrials.gov/study/NCT03304028
Performance assessment of wheat genotypes based on the superiority index using additive main and multiplicative interaction effects and BLUP analysis
Authors: Verma Ajay , Singh Gyanendra Pratap
Published: September 2023

The simultaneous use of additive main and multiplicative interaction effects (AMMI) and best linear unbiased predictors (BLUP) has been reflected in the multi-location evaluation of trials for number of crops. The additional advantages of both these approaches would be combined in superiority index (SI) to have an edge over the commonly used approaches. The promising wheat genotypes had been considered under multi location trails in Peninsular zone of India during the cropping seasons of 2018-2019 and 2019-2020. The highly significant environmental effects contributed 44.1% & 35.3% of total sum of squares in the AMMI analysis, 20.6% & 26.2% were augmented by G × E interaction, while 10.8% & 7.5% were contributed by the genotypes.Wheat genotypes of UAS3001, MACS6222, GW322, and DDW48 expressed their superiority in BLUP values. Superiority indexes and adaptability measures had identified WHD964 and DDW48 genotypes for the second year of study. More than 75% variations among the considered measures were due to the first two interaction principal components (IPCA’s) under Biplot analysis. Number of superiority index measures were clustered with adaptability measures in the same quadrant. Superiority index, the weighted measure of yield and consistent performance of genotypes would be more appropriate for stability and adaptabilities studies.
Improving basil productivity in coastal sandy soil Yogyakarta by balanced Urea-ZA (N-S) fertilizers and application of soil amendment to increase fertilization effectiveness
Authors: Wulandari Cahyo , Yuwono Nasih Widya , Pravasta Yudhistira Galang , Lestari Sri
Published: September 2023

Basil is a plant that can be cultivated in Psamment (coastal sandy soil). Basil requires nitrogen (N) and sulfur (S), so the N-S balance is needed to obtain optimal results. Psamment contains low colloid, causing nutrients to be barely bound and easily lost. Zeolite and biochar can be a solution. This study aimed to determine the composition and frequency of fertilization, as well as the use of soil amendment for basil growth. This research consisted of two interrelated studies arranged in a Randomized Complete Block Design. The research was conducted in Bugel, Panjatan, Kulon Progo, and the analysis was performed at the Soil Department Laboratory, Faculty of Agriculture, Universitas Gadjah Mada. The first study consisted of two factors, namely Urea-ZA composition (0:0, 60:40, 70:30, 80:20, 90:10, and 100:0) and frequency of fertilization (every 1 and 2 weeks). The application of Urea-ZA (80:20) gave the best fresh-dry weight, N-S content, and N-S uptake of basil, and this result was used as the reference for the second study. The second study consisted of two factors, namely Urea-ZA fertilizer doses (50%, 75%, and 100%), and types and doses of soil amendment (without amendment, zeolite 7.5 t/ha, zeolite 15 t/ha; biochar 7.5 t/ha, and biochar 15 t/ha). It can be concluded that soil amendments application improved the chemical properties of psamment, fresh-dry weight, N-S content, and N-S uptake of basil. Furthermore, biochar and zeolite could increase the effectiveness of fertilization, so the dose of Urea-ZA fertilizer could be reduced until 50%.
Del pecado como símbolo racional entre Pelagio y Agustín según Paul Ricoeur
Authors: Mariano Da Rosa Luiz Carlos
Published: September 2023

Focusing on sin in Pelagius as a possibility of exercising freedom and individual responsibility, this paper points out the defense of neutrality, involving the creation of the human being and his capacity for good and evil, emphasizing the freedom of  will and its absolute indeterminacy, linking sin to choice. Therefore, by attributing the condition of locus of the establishment of the existential ethical-logical experience, involving the exercise of freedom, to will, Pelagius opposes the thesis of original sin as a psycho-biological, intellect-affective, and volitional-consciential inheritance transmitted by the human archetype in Adam for his offsprings. Thus, pointing to will as the cause of sin in a movement that converges to end its imputation to the agent as a holder of will in exercise, the text shows that Augustine paradoxically affirms the human tendency to practice evil as a result of Adamic inheritance, which imposes on its posterity the condition of absolute depravity and inescapable guilt, insofar as the human being is constituted as such in a state of holy innocence in a process that attributes to sin the condition of a product of human choice through the exercise of their freedom and full conscience. Finally, the paper examines sin as a rational symbol between Pelagius and Augustine, according to Paul Ricoeur, who affirms the need for a process able to deconstruct the concept due to the emergence of the orthodox intention as a straight and ecclesial meaning.
A Retrospective Seroprevalence Study of Dengue, Chikungunya and Co-Infection virus: a Hospital Based Study from Theni, Tamil Nadu
Authors: Gopinath R. , Dhanasezhiyan A. , Krishnapriya S. , Prasanth S. Mathan , Thangam G. Sucila
Published: September 2023

Viral-borne diseases have recently gained significant public health importance in the current world. The Viral Research and Diagnostic Laboratory (VRDL) located at Government Theni Medical College (GTMC), Theni, Tamil Nadu, conducts the diagnosis of common virus infections. The purpose of this study is to investigate the seroprevalence of dengue (DENV) and chikungunya (CHIKV) virus infections, as well as their co-infection, in people who have clinical symptoms. From January 2018 to June 2023, serum samples were collected from clinically suspected patients at the tertiary care hospital in Theni, Tamil Nadu. DENV and CHIKV were detected using an enzyme-linked immunosorbent assay (ELISA) in all of the samples. A total of 16,997 cases were enrolled, out of which 11264/2971(26.3%) tested positive for Dengue IgM, 1395/288 (20.6%) for Dengue NS1 Ag, 19/3(15.7%) for IgG, followed by 4319/3388(8.9%) of CHIKV IgM. Fever (n = 16598, 97.6%) was the most prevalent clinical characteristic in all probable dengue and chikungunya patients. Other symptoms were chills (n = 11252, 66.1%), arthralgia (n = 10245, 60.2%), headache (n = 11354, 66.8%), and joint pain (n = 11256, 66.2%). The findings showed a lesser likelihood of acquiring both DENV and CHIKV infections at the same time; however, the risk is still not trivial. This study investigates the clinical presentation of Dengue-Chikungunya patients. The rising prevalence of dengue and chikungunya, as well as their co-infection, need thorough monitoring of endemic areas and good patient care management.
vigencia del mito como función psíquica activa en la búsqueda inconsciente de sentido
Authors: Ramírez Giraldo Augusto César , Gutiérrez Marín Jiminson Eduardo
Published: September 2023

Este texto brinda un aporte al esclarecimiento por la pregunta sobre la vigencia del mito como función psíquica activa en la búsqueda inconsciente de sentido para la vida del hombre actual, que se asume alejado de todo pensamiento mítico y ritual, y que habita un contexto en el que la razón es el único criterio de verdad. El texto se enfoca, por lo tanto, en analizar el poder e influencia de esta realidad anímica en el mundo consciente, y en pensar si tiene este fenómeno imaginal alguna utilidad en el proceso civilizador o, al contrario, el mito es más bien un lastre, una simple quimera que dificulta la comprensión y aceptación de las complicadas condiciones de existencia hoy, y si ocuparse de este universo imaginal y simbólico cumple con las expectativas y deseos inconscientes del hombre actual de encontrar sentido y significado a su existencia. La investigación se apoya metodológicamente en la fenomenología psíquica propuesta por Carl Jung, además se nutrirá en gran medida de los aportes teóricos y conceptuales del filósofo rumano Mircea Eliade. En el mundo racional, el inconsciente del hombre actual no cesa de presentar innumerables mitos y símbolos, dado que el ser humano como tal nunca se halla del todo desprendido del mundo imaginal, pues continuamente los individuos son influenciados de forma inconsciente por modelos de conducta mitológicos ancestrales, que siguen latentes en lo más profundo del ser humano.
Experimental Study of Electro Discharge Machining (EDM) on Mild Steel (E-250) using Copper Electrode
Authors: Pratap Raj , Yadav Dr. S. K. S.
Published: September 2023

Abstract: Electro-discharge machining is used for machining different types of hard materials which are electrically conductive and these materials are particularly challenging to manufacture using any other machining method. In electro-discharge machining electrical energy is transformed into thermal energy which is approximately 8000 to 12000 degrees Celsius and due to high thermal energy material melting and vaporising. In electro-discharge machining, three types of electrode materials are used which are copper, brass and graphite, Of all three materials, graphite has the highest electrical conductivity and brass has the lowest electrical conductivity. Electro-discharge machining process suitable for generating complex shapes and profiles. In this paper, a Copper electrode was used for machining mild steel (E-250) and analysed the MRR and Ra with a variation of discharge current keeping other variables constant and studying the consequence of different discharge currents on MRR and Ra.
Are Quantum Computers Threat to Privacy?
Authors: Surdi Ishan Rahul
Published: September 2023

Abstract: Quantum computers work in a fundamentally different way from classical computers. Each qubit is in a superposition of 0 and 1 and can be used to store information. Quantum computers have the potential to revolutionize many industries. They can solve exponentially more difficult problems than conventional computers in seconds. Encryption is the process of turning plain text into ciphertext using a key. By measuring the quantum register we can find the marked number. Grover's algorithm can be used to solve a variety of problems related to finding an item in an unsorted database, such as cryptography, optimization, or machine learning. The main limitation of Grover's algorithm is that it is probabilistic. This means that there is a chance that the algorithm will not find the highlighted item after a certain number of iterations. However, the probability that the algorithm does not find the highlighted element decreases exponentially with the number of iterations. The Grover algorithm is a powerful quantum algorithm with many potential applications. However, it is still only a theoretical algorithm and has not been implemented on actual quantum computers. .. Many challenges must be overcome before the Grover algorithm can be used to solve real-world problems
Safety and Theft Detection in Autonomous Vehicles
Authors: S Jayasurya , N Dr. Shankaraiah
Published: September 2023

Abstract: The proposed work revolves around bolstering automotive cybersecurity and safety through a comprehensive strategy that encompasses various technological facets. The workflow commences with an advanced accident detection mechanism, facilitated by a set of IoT components such as bump switches, buzzers, ESP32 modules, switches, and device sensors. Upon detecting an accident, these components collaborate to promptly notify relevant entities, potentially minimizing the aftermath of collisions. Furthermore, the incident data is securely stored in the cloud, ensuring its availability for subsequent analysis and response coordination. The crux of this work lies in its application of machine learning algorithms—K-Means and Support Vector Machine (SVM) to tackle cybersecurity challenges. These algorithms undertake the vital task of classifying different types of cyber attacks. By learning patterns from labelled datasets, the algorithms become adept at identifying and categorizing various cyber threats. This classification empowers the system to swiftly recognize and respond to potential attacks, mitigating potential damages and risks to the vehicle's security. Another noteworthy feature of this work is its proactive stance against theft. Through a network of IoT components including switches and sensors, the system is primed to detect any unauthorized tampering or theft of vehicle parts. In such instances, the system triggers immediate notifications to relevant parties, thereby facilitating swift intervention and recovery measures. This real-time response capability greatly enhances the security of the vehicle and its components.
Emerging TPACK & Digitalization in Education for Sustainable Development: Voices of Secondary Education Teachers
Authors: Setoningsih Dian Asmi
Published: September 2023

One of the frameworks used nowadays to incorporate technology into the teaching and learning process is technological pedagogical and content knowledge (TPACK). The investigation of teachers' TPACK, specifically their comprehension, process, and obstacles in a classroom context, has not received much research, though. In order to better understand TPACK and digitalization in the secondary education classroom, this study will examine it from the viewpoints of teachers. The information was gathered from three teachers who were at Thursina IIBS Malang, East Java, Indonesia. The study's methodology included a qualitative study. The researchers used a triangulation of data sources, including interviews, observations, and documents, to collect their responses. The verbatim transcriptions of the interviews data were followed by a thematic analysis. The results of the current study reveal four key issues, including teachers' understanding of TPACK, the acquisition of TPACK, teacher perceived level of digital literacy and teachers' challenges with TPACK. The teachers utilized a variety of ways to acquire TPACK, and they had different perspectives on TPACK. However, applying TPACK presented many benefits for the teachers. The results of this study may have an impact on how teachers should proceed with their professional development.
Arabic–English Pocket Dictionary (Cory) Based on Symbolic Art to Increase Arabic Vocabulary Mastery in Elementary School
Authors: Kiki Safitri  , Nurhidayati  , Mahliatussikah Hanik , Pabiyah Toklubok@Hajimaming
Published: September 2023

The purpose of this study is to describe the Arabic–English Pocket Dictionary (Cory) Based on Symbolic Art to increase Arabic vocabulary mastery in elementary school. To find out how Cory is implemented and increased, this research uses classroom action research methods. Classroom action research (CAR) is a research method whose implementation is carried out to find out problems in the learning process as well as steps that teachers can take to improve the quality of learning, which refers to the research implementation process, consisting of four stages, namely (1) Planning, (2) Actualing, (3) Observation, and (4) Reflecting (reflecting in general on the research process). This must be done in at least two cycles if it shows the target that has been determined. The research process was carried out in two cycles. The results of the first and second cycle post-tests obtained an average score of 76 and 95, respectively, with learning completeness results in each cycle of 70% and 100%. Thus, the percentage increase in student learning outcomes is 30%.
La prensa feminista ante el problema de la mortalidad infantil y la labor de las instituciones de beneficencia: Acción Femenina y La Mujer Nueva
Authors: Neves Guzmán Camila
Published: September 2023

Este trabajo plantea que Acción Femenina y La Mujer Nueva defendieron los derechos de las madres obreras producto de su doble explotación y los estragos causados por la mortalidad infantil. A partir del análisis de estos medios de comunicación se examina el discurso feminista en torno a la maternidad y la mortalidad infantil infiriendo que a las madres obreras les correspondió la doble labor de los cuidados y el trabajo productivo por la subordinación a la que estaban sometidas en una sociedad “altamente androcéntrica”. Ante el problema de la mortalidad infantil, ambos periódicos criticaron la labor de las instituciones de beneficencia de carácter privado caracterizada como “parcelada y poco metódica” y, también, denunciaron la ausencia del Estado en materia de protección materno infantil.
Strategi Bimbingan Manasik Haji dalam Meningkatkan Keterampilan Jamaah Haji pada Kantor Kementerian Agama Kota Banda Aceh
Authors: Ridwan Ridwan
Published: September 2023

In the implementation of the Hajj and Umrah pilgrimages, surges or increases always occur in Indonesia every year, and are the cause of the emergence of a complex problem. there are many problems within the scope of hajj and umrah, such as the lack of a guiding role by the guide, resulting in the ignorance of the pilgrims about the Hajj and Umrah Organizing Law. The purpose of this study was to determine the Hajj ritual guidance strategy for the Office of the Ministry of Religion of the City of Banda Aceh and the factors that support and hinder the strategy of guidance for the Hajj rituals in improving the skills of pilgrims at the Office of the Ministry of Religion of the City of Banda Aceh. This research was conducted with a field study using a qualitative descriptive method. Data collection techniques were carried out through interviews, observation and documentation. The results of the study show that the Strategy for guidance on Hajj rituals of the Office of the Ministry of Religion of the City of Banda Aceh in improving the skills of pilgrims by implementing a management strategy which includes 4 stages, the first is planning (planning). The second is organizing, the third is actuating, the fourth is supervision. Factors that support the existence of competent Hajj ritual guides, Have a legal umbrella, availability of adequate facilities and infrastructure, Inhibiting factors, there is a profile of pilgrims whose education level is elementary school, there is an advanced age for pilgrims so that their physical condition decreases, and has an effect on the lack of concentration of pilgrims pilgrimage in the implementation of Hajj ritual guidance
Crianças nas mídias: uma análise das conversações no Twitter sobre o caso Balenciaga
Authors: Othon Renata Alves de Albuquerque , Luisa Ochi Flexor Carina , Da Costa Gustavo
Published: September 2023

Este artigo tem como objetivo mapear e compreender as conversações no Twitter em torno da campanha publicitária acusada de pedofilia e exploração sexual infantil veiculada pela marca Balenciaga em novembro de 2022. Para tanto, utilizou-se como arcabouço teórico as contribuições da Sociologia da Infância no que diz respeito aos sentimentos de inocência e proteção socialmente construídos e aos direitos das crianças recém-conquistados. A partir da metodologia da análise de redes sociais, investigou-se o recorte temporal de 01 de novembro a 31 de dezembro de 2022, com ênfase nos dias 27 a 30 de novembro. Os resultados apontam para a efemeridade e superficialidade do debate, que não trouxe preocupações efetivas com os direitos das crianças no âmbito da campanha em questão e/ou no que tange à exploração comercial do público infantil.
Anaerobic fungi: the effective warriors in biomass degradation and fermentation
Authors: Kovács Kornél L. , Kovács Etelka , Szűcs Csilla , Bagi Zoltán , Rákhely Gábor
Published: September 2023

Substantial wealth of knowledge about anaerobic fungi has accumulated in
recent years, which may guide the attention of the
biotechnology-oriented scientists towards the possible exploitation of
their fascinating capabilities. Very efficient, unique and complex
enzyme systems of anaerobic fungi play determining role in the
conversion of lignocellulosic fodder to milk and meat in mammalian
herbivores. Mitigation of the concomitant greenhouse gas emission by
ruminants is a major environmental, climate change issue. In turn,
controlled management of the inter-kingdom syntrophic co-operations
among the eukaryotic anaerobic fungi, bacteria and archaea can lead to
the production of valuable bio-fuels, e.g. bio-methane, bio-hydrogen,
bio-ethanol, and organic acids, the latter could serve as building
blocks in numerous biosynthetic processes in circular bioeconomy.
Exploiting Protein Language Models for the Precise Classification of Ion Channels and Ion Transporters
Authors: Ghazikhani Hamed , Butler Gregory
Published: September 2023

This study presents TooT-PLM-ionCT, a holistic framework that exploits
the capabilities of six diverse Protein Language Models (PLMs) -
ProtBERT, ProtBERT-BFD, ESM-1b, ESM-2 (650M parameters), and ESM-2 (15B
parameters) - for precise classification of integral membrane proteins,
specifically ion channels (ICs) and ion transporters (ITs). As these
proteins play a pivotal role in the regulation of ion movement across
cellular membranes, they are integral to numerous biological processes
and overall cellular vitality. To circumvent the costly and
time-consuming nature of wet lab experiments, we harness the predictive
prowess of PLMs, drawing parallels with techniques in natural language
processing. Our strategy engages six classifiers, embracing both
conventional methodologies and a deep learning model, to segregate ICs
and ITs from other membrane proteins, as well as differentiate ICs from
ITs. Furthermore, we delve into critical factors influencing our tasks,
including the implications of dataset balancing, the effect of frozen
versus fine-tuned PLM representations, and the potential variance
between half and full precision floating-point computations. Our
empirical results showcase superior performance in distinguishing ITs
from other membrane proteins and differentiating ICs from ITs, while the
task of discriminating ICs from other membrane proteins exhibits results
commensurate with the current state-of-the-art.