bluuebunny/crossref_metadata_2025 huggingface dataset:
Cross-reactivity reduced dengue virus serotype 2 vaccine does not confer cross-protection against other serotypes of dengue viruses
Authors: Galula Jedhan Ucat , Yang Chung-Yu , Davis Brent S. , Chang Gwong-Jen J. , Chao Day-Yu
Published: November 2018

The four serotypes of dengue virus (DENV) cause the most important rapidly emerging arthropod-borne disease globally. The humoral immune response to DENV infection is predominantly directed against the immunodominant cross-reactive weakly neutralizing epitopes located in the highly conserved fusion peptide of ectodomain II of envelope (E) protein (EDIIFP). Antibodies recognizing EDIIFP have been shown to associate with immune enhancement in an ex vivo animal model. In this study, we explored how prime-boost strategies influence the immunogenicity of a cross-reactivity reduced (CRR) DENV-2 vaccine with substitutions in EDIIFP residues (DENV-2 RD) and found that mice in various DENV-2 RD prime-boost immunizations had significantly reduced levels of EDIIFP antibodies. In addition, heterologous DENV-2 RD DNA-VLP prime-boost immunization induced higher and broader levels of total IgG and neutralizing antibodies (NtAbs) although IgG titers to DENV-2 and 3 were statistically significant. Consistently, mice from DENV-2 RD DNA-VLP prime-boost immunization were fully protected from homologous DENV-2 lethal challenge and partially protected (60% survival rate) from heterologous lethal DENV-3 challenge. Our results conclude that the CRR DENV-2 RD vaccine requires a multivalent format to effectively elicit a balanced and protective immunity across all four DENV serotypes.

Importance

The low vaccine efficacy of the live-attenuated chimeric yellow fever virus-DENV tetravalent dengue vaccine (CYD-TDV) is unexpected and there is an urgent need to develop a next generation of dengue vaccine. Antibodies against the fusion peptide in envelope protein (E) ectodomain II (EDIIFP) can potentially induce a severe disease via antibody-dependent enhancement (ADE) of infection. This study evaluated different formats of an EDIIFP-modified DENV-2 vaccine (DENV-2 RD) in its capability of inducing a reduced EDIIFP antibodies, and sculpting the immune response towards an increased DENV complex-reactive neutralizing antibodies (CR NtAb). The results from this study confirmed the poor correlate of neutralizing assay with protection as suggested by the results of CYD-TDV clinical trials. There is a urgent need to develop a biological correlate with protection while evaluating the efficacy of the next generation dengue vaccine.
Islet macrophages shift to a reparative state following pancreatic beta-cell death and are a major source of islet IGF-1
Authors: Nackiewicz D. , Dan M. , Speck M. , Chow S. Z. , Chen Y.C. , Pospisilik J. A. , Verchere C. B. , Ehses J. A.
Published: November 2018

Macrophages play a dynamic role in tissue repair following injury. Here we found that following streptozotocin (STZ)-induced beta-cell death, mouse islet macrophages expressed increasedIgf1, decreased proinflammatory cytokine expression, and transcriptome changes consistent with macrophages undergoing efferocytosis and having an enhanced state of metabolism. Macrophages were the major, if not sole, contributors to islet IGF-1 production. Adoptive transfer experiments showed that macrophages can maintain insulin secretionin vivofollowing beta-cell death with no effects on islet-cell turnover. IGF-1 neutralization during STZ-treatment decreased insulin secretion without affecting islet-cell apoptosis or proliferation. Interestingly, high fat diet (HFD) combined with STZ further skewed islet macrophages to a reparative state. Finally, islet macrophages fromdb/dbmice also expressed decreased proinflammatory cytokines and increasedIgf1mRNA. These data have important implications for islet biology and pathology and show that islet macrophages preserve their reparative state following beta-cell death even during HFD feeding and severe hyperglycemia.
Mismatch repair disturbs meiotic class I crossover control
Authors: Cooper Tim J. , Crawford Margaret R. , Hunt Laura J. , Marsolier-Kergoat Marie-Claude , Llorente Bertrand , Neale Matthew J.
Published: November 2018

Sequence divergence, mediated by the anti-recombinogenic activity of mismatch repair (MMR), forms a barrier to meiotic recombination and in turn the formation of viable gametes. However, rather than MMR acting as a non-specific impediment to meiotic recombination, here we provide evidence that at regions of greater sequence divergence MMR preferentially suppresses interfering (class I) crossovers (COs). Specifically, as measured in twoSaccharomyces cerevisiaehybrids containing thousands of DNA-sequence polymorphisms, removal of MMR components increases both the frequency of CO formation and the uniformity of the observed CO distribution. At fine scale, CO positions are skewed away from polymorphic regions in MMR-proficient cells, but, critically, not when members of the class I CO pathway,MSH4orZIP3, are inactivated. These findings suggest that class I COs are more sensitive to heteroduplex DNA arising during recombination. Simulations and analysis of Zip3 foci on meiotic chromosomes support roles for Msh2 both early and late in the class I CO maturation process. Collectively, our observations highlight an unexpected interaction between DNA sequence divergence, MMR, and meiotic class I CO control, thereby intimately linking the regulation of CO numbers and their distribution to pathways contributing to reproductive isolation and eventual speciation.
Millimetre wave radiation activates leech nociceptors via TRPV1-like receptor sensitisation
Authors: Romanenko S. , Harvey A. R. , Hool L , Begley R. , Fan S. , Wallace V. P.
Published: November 2018

Due to new applications such as wireless communications, security scanning, and imaging the presence of artificially generated high frequency (30-300 GHz) millimetre-wave (MMW) signals in the environment is increasing. Although safe exposure levels have been set by studies involving direct thermal damage to tissue, there is evidence that MMWs can have an impact on cellular function, including neurons. Earlier in vitro studies have shown that exposure levels well below the recommended safe limit of 1mW/cm2 cause changes in the action potential (AP) firing rate, resting potential, and AP pulse shape of sensory neurons in leech preparations, as well as alter neuronal properties in rat cortical brain slices; these effects differ from changes induced by direct heating. In this paper we examine continuous MMW power (up to 80 mW/cm2 at 60 GHz) and evaluate the responses in the thermosensitive primary nociceptors of the medicinal leech (genus Richardsonianus Australis). The results show that MMW exposure causes an almost two-fold decrease in the threshold for activation of the AP compared with conductive heating (3.6±0.4 mV vs. 6.5±0.4 mV respectively). Our analysis suggests that MMW exposure mediated threshold alterations are not caused by enhancement of voltage gated sodium and potassium conductance. Moreover, it appears that MMW exposure has a modest suppressing effect on membrane excitability. We propose that the reduction in AP threshold can be attributed to sensitization of the TRPV1-like receptor in the leech nociceptor. In silico modelling supported the experimental findings. Our results provide evidence that MMW exposure stimulates specific receptor responses that differ from direct conductive heating, fostering the need for additional studies.
Robust and Interpretable PAM50 Reclassification Exhibits Survival Advantage for Myoepithelial and Immune Phenotypes
Authors: Mathews James C. , Nadeem Saad , Levine Arnold J. , Pouryahya Maryam , Deasy Joseph O. , Tannenbaum Allen
Published: November 2018

We introduce a classification of breast tumors into 7 classes which are more clearly defined by interpretable mRNA signatures along the PAM50 gene set than the 5 traditional PAM50 intrinsic subtypes. Each intrinsic subtype is partially concordant with one of our classes, and the 2 additional classes correspond to division of the classes concordant with the Luminal B and the Normal intrinsic subtypes along expression of the Her2 gene group. Our Normal class shows similarity with the myoepithelial mammary cell phenotype, including TP63 expression (specificity: 80.8% and sensitivity: 82.8%), and exhibits the best overall survival (89.6% at 5 years). Though Luminal A tumors are traditionally considered the least aggressive, our analysis shows that only the Luminal A tumors which are now classified as myoepithelial have this phenotype, while tumors in our luminal class (concordant with Luminal A) may be more aggressive than previously thought. We also find that patients with Basal tumors surviving to 48 months exhibit favorable survival rates when certain markers for B-lymphocytes are present and poor survival rates when they are absent, which is consistent with recent findings.
Notch-Mediated Polarity Decisions in Mechanosensory Hair Cells
Authors: Jacobo A. , Dasgupta A. , Erzberger A. , Siletti K. , Hudspeth A. J.
Published: November 2018

The development of mechanosensory epithelia, such as those of the auditory and vestibular systems, results in the precise orientation of mechanosensory hair cells and consequently directional sensitivity. After division of a precursor cell in the zebrafish’s lateral line, the daughter hair cells differentiate with opposite mechanical sensitivity. Through a combination of theoretical and experimental approaches, we show that Notch1a-mediated lateral inhibition produces a bistable switch that reliably gives rise to cell pairs of opposite polarity. Using our mathematical model of the process, we predict the outcome of several genetic and chemical alterations to the system, which we then confirm experimentally. We show that Notch1a downregulates the expression of Emx2, a transcription factor known to be involved in polarity specification, and acts in parallel with the planar-cell-polarity system to determine the orientation of hair bundles. By analyzing the effect of simultaneous genetic perturbations to Notch1a and Emx2 we infer that the generegulatory network determining cell polarity includes undiscovered polarity effectors.
Relationship between Parathyroid Hormone Levels and Hazards of Fracture, Vascular Events and Death in Stage 3 and 4 Chronic Kidney Disease
Authors: Geng Sinong , Kuang Zhaobin , Peissig Peggy L. , Page David , Maursetter Laura , Hansen Karen E.
Published: November 2018

Background and Objectives:

Chronic kidney disease (CKD) affects ∼20% of older adults and secondary hyperparathyroidism (HPT) is a common condition in these patients. Studies have linked HPT to a greater risk of fractures, vascular events and mortality. However, the optimal parathyroid hormone (PTH) level needed to minimize these events remains uncertain.

Design, setting, participants and measurements:

We assessed relationships between baseline serum PTH levels and the subsequent 10-year probability of clinical fractures, vascular events and death in stage 3 and 4 CKD patients. We used Marshfield Clinic Health System electronic health records to analyze data from adult CKD patients spanning from 1985 to 2013. We required ≥2 PTH measurements at baseline and used ICD-9 codes to identify medical conditions, fractures, vascular events and death. In multivariate models, we assessed relationships between serum PTH and the three clinical outcomes, controlling for age, gender, co-morbidities and osteoporosis medication.

Results:

7594 subjects had a mean age of 68±13 years and 55% were women. Fractures, vascular events and death occurred in 19%, 60% and 29% of the cohort, respectively. In multivariate models including the whole cohort regardless of PTH assay, the probability of fracture, vascular events and death were minimized at a PTH of 23, 50 and 50 pg/mL. Below these cutpoints, the probability of fractures and death dramatically increased. When confining the analysis to patients measured using a 2ndgeneration PTH assay (n=5108), the hazards of fracture, vascular events and death were minimized at a PTH of zero, 60 and 58 pg/mL. Any of these clinical outcomes was minimized at a baseline PTH of 58 pg/mL.

Conclusions:

Our study suggests that parathyroid hormone levels around 60 pg/mL might reduce the risk of fractures, vascular events and death in CKD patients. Additional epidemiologic studies and randomized clinical trials are needed to confirm these findings.
Functional role ofpax6in eye and central nervous system development in the annelidCapitella teleta
Authors: Klann Marleen , Seaver Elaine C.
Published: November 2018

The transcription factor Pax6 is an important regulator of early animal development. Loss of function mutations ofpax6in a range of animals results in a reduction or complete loss of the eye, a reduction of a subset of neurons, and defects in axon growth. There are no studies focusing on the role ofpax6during development of any lophotrochozoan representative, however, expression ofpax6in the developing eye and nervous system in a number of species suggest thatpax6plays a highly conserved role in eye and nervous system formation. We investigated the functional role ofpax6during development of the marine annelidCapitella teleta. Expression ofpax6transcripts inC. teletalarvae is similar to patterns found in other animals, with distinct subdomains in the brain and ventral nerve cord as well as in the larval and adult eye. To perturbpax6function, two different splice-blocking morpholinos were used. Larvae resulting from injections with either morpholino show a reduction of thepax6transcript, and development of both the larval eyes and the central nervous system architecture are highly disrupted. Preliminary downstream target analysis confirms disruption in expression of some components of the retinal gene regulatory network, as well as disruption of genes involved in nervous system development. Results from this study, taken together with studies from other species, reveal an evolutionarily conserved role forpax6in eye development, and in neural specification and development.
PTPN22 interacts with EB1 to regulate T cell receptor signaling
Authors: Zhang Xiaonan , Bai Bin , Wang Tao , Zhao Jiahui , Zhang Na , zhao Yanjiao , Wang Xipeng , Yu Yang , Wang Bing
Published: November 2018

PTPN22 has been reported as an important negative regulator of T cell signaling. Here we identified EB1 as an associated protein of PTPN22 via 2-hybrid and mass spectrometry screening.

Recently the phosphorylation of EB1 has been proved in the regulation of T cell receptor (TCR) mediated signaling pathway. Our results shown that PTPN22 interacted with EB1 through the P1 domain of PTPN22, and regulated the Y247 phosphorylation site of EB1. The subsequent results suggest that PTPN22 interacts with EB1 and regulate the phosphorylation of EB1, which results in the regulation of the expression of T cell activation markers of CD25 and CD69, and the phosphorylation levels of the T cell signaling molecules, such as ZAP-70, LAT and Erk, ultimately resulting in NFAT transcription factors entering the nucleus and regulating the secretion of cytokine IL-2. This newly identified interaction between PTPN22 and EB1 may play an important role in TCR signal pathways.
Selection of trait-specific markers and multi-environment models improve genomic predictive ability in rice
Authors: Bhandari Aditi , Bartholomé Jérôme , Cao Tuong-Vi , Kumari Nilima , frouin Julien , Kumar Arvind , Ahmadi Nourollah
Published: November 2018

Developing high yielding rice varieties that are tolerant to drought stress is crucial for the sustainable livelihood of rice farmers in rainfed rice cropping ecosystems. Genomic selection (GS) promises to be an effective breeding option for these complex traits. We evaluated the effectiveness of two rather new options in the implementation of GS: trait and environment-specific marker selection and the use of multi-environment prediction models. A reference population of 280 rainfed lowland accessions endowed with 215k SNP markers data was phenotyped under a favorable and two managed drought environments. Trait-specific SNP subsets (28k) were selected for each trait under each environment, using results of GWAS performed with the complete genotype dataset. Performances of single-environment and multi-environment genomic prediction models were compared using kernel regression based methods (GBLUP and RKHS) under two cross validation scenario: availability (CV2) or not (CV1) of phenotypic data for the validation set, in one of the environments. The most realistic trait-specific marker selection strategy achieved predictive ability (PA) of genomic prediction was up to 22% higher than markers selected on the bases of neutral linkage disequilibrium (LD). Tolerance to drought stress was up to 32% better predicted by multi-environment models (especially RKHS based models) under CV2 strategy. Under the less favorable CV1 strategy, the multi-environment models achieved similar PA than the single-environment predictions. We also showed that reasonable PA could be obtained with as few as 3,000 SNP markers, even in a population of low LD extent, provided marker selection is based on pairwise LD. The implications of these findings for breeding for drought tolerance are discussed. The most resource sparing option would be accurate phenotyping of the reference population in a favorable environment and under a managed drought, while the candidate population would be phenotyped only under one of those environments.
Crystallization of Ge2Sb2Te5 and nitrogren-doped Ge2Sb2Te5 phase-change-materials thin films studied by in situ combined X-ray scattering techniques
Authors: Fillot Frédéric , Sabbione Chiarra , Pierre François , Hippert Françoise , Noé Pierre
Published: November 2018

The phase change from the amorphous to crystalline state which occurs upon thermal annealing in prototypical Ge2Sb2Te5 and nitrogen-doped Ge2Sb2Te5 phase-change-materials (PCM) thin films is studied by concomitant, complementary and combined in situ and ex situ X-ray diffraction (XRD) and X-ray reflectivity (XRR) techniques. It is demonstrated that combined in situ X-ray scattering techniques allow accurate investigation and clarification of the structural, morphological and mechanical variations occurring in the films upon crystallization. The crystallization process is correlated with volume shrinkage (densification and thickness reduction) and with structural change with a tensile strain build-up. The comparison of Ge2Sb2Te5 and nitrogen-doped Ge2Sb2Te5 reveals a significant slowdown of the crystallization process, induced by the incorporation of nitrogen. However, the mechanisms involved in the phase change are not strongly modified by the incorporation; rather, the crystallization process is inhibited because of the presence of nitrogen. In this way, different stages of the crystallization process can be observed. The combined XRD/XRR analysis gives new insights on the stress components built up in phase-change materials. First, at the early stage of crystallization, a large hydrostatic tensile stress builds up in the PCM thin film. Afterwards, concomitant grain growth, viscous flow, densification and thickness accommodation are observed, which lead to a partial stress relaxation in the PCM films. This combined characterization technique offers a new approach that may further our understanding of the phase change involved.
Sharing powder diffraction raw data: challenges and benefits
Authors: Aranda Miguel A. G.
Published: November 2018

Scientific data are as important as scientific publications. If this statement holds true, why are we not routinely sharing scientific data? The tools are now out there, for instance Zenodo and related repositories. It could be a lack of motivation of researchers derived from an apparent lack of short-term reward. Here the author will try to show the importance of sharing ready-to-analyse raw powder diffraction data with immediate benefits for authors and for the wider community. Moreover, it is speculated that sharing curated scientific data may have more important medium-term benefits, including credibility and not least reproducibility. Raw data sharing is coming.
Aging as a topic in a business magazine: an opportunity or threat for management?
Authors: Salminen Hanna Maria , Wang Qian , Aaltio Iiris
Published: November 2018

Purpose

Recently, research on aging in the work-life context from the perspective of how to manage, support and retain an aging workforce has increased among management scholars, and therefore is contributing to the current societal need to extend work careers. The purpose of this paper is to analyze the articles discussing aging in the work-life context in the Finnish business magazine Talouselämä (Economic Life) during the years 2002–2017.

Design/methodology/approach

A total of 81 articles were included in the analysis. They were classified into seven themes as a result of a content analysis. Three levels of discussions on aging were identified: societal, organizational and individual. These levels were further analyzed in order to revel what kind of issues have been emphasized or overlooked. The results were discussed in the context of Finnish work life.

Findings

The findings showed that aging has been presented in a passive and deterministic (or at least neutral) tone. Most of the articles focused on the consequences and actions related to an aging workforce at the societal level. At the individual level, aging was mainly discussed in terms of changes related to work ability and functioning, with aging individuals as the actors responsible for managing and controlling the effects of their own aging process. The organizational-level discussion on aging was limited and narrow, mostly lacking any discussion of the role of organizations as responsible actors or from the perspective of Corporate Social Responsibility (CSR).

Practical implications

Organizations could take a more active and broader role in terms of supporting the longer working careers of older employees. Professional magazines could deal more with “age-aware” research as it relates to organizations, especially the potential and opportunities of the aging workforce. Aging research could promote media level publishing and applications of knowledge.

Originality/value

Few critically oriented management studies have investigated how aging is presented and discussed in business magazines.
Translating emotional insights from hospitality employees’ comments
Authors: Young Lisa M. , Gavade Swapnil Rajendra
Published: November 2018

Purpose

The purpose of this paper is to use the data analysis method of sentiment analysis to improve the understanding of a large data set of employee comments from an annual employee job satisfaction survey of a US hospitality organization.

Design/methodology/approach

Sentiment analysis is used to examine the employee comments by identifying meaningful patterns, frequently used words and emotions. The statistical computing language, R, uses the sentiment analysis process to scan each employee survey comment, compare the words with the predefined word dictionary and classify the employee comments into the appropriate emotion category.

Findings

Employee responses written in English and in Spanish are compared with significant differences identified between the two groups, triggering further investigation of the Spanish comments. Sentiment analysis was then conducted on the Spanish comments comparing two groups, front-of-house vs back-of-house employees and employees with male supervisors vs female supervisors. Results from the analysis of employee comments written in Spanish point to higher scores for job sadness and anger. The negative comments referred to desires for improved healthcare, requests for increased wages and frustration with difficult supervisor relationships. The findings from this study add to the growing body of literature that has begun to focus on the unique work experiences of Latino employees in the USA.

Originality/value

This is the first study to examine a large unstructured English and Spanish text database from a hospitality organization’s employee job satisfaction surveys using sentiment analysis. Applying this big data analytics process to advance new insights into the human capital aspects of hospitality management is intriguing to many researchers. The results of this study demonstrate an issue that needs to be further investigated particularly considering the hospitality industry’s employee demographics.
Which can affect more? Cause marketing or cause-related marketing
Authors: Heidarzadeh Hanzaee Kambiz , Sadeghian Mona , Jalalian Saeed
Published: November 2018

Purpose

The purpose of this study is to investigate the effects of corporate social responsibility on customer satisfaction, loyalty and repurchase with or without cause-related marketing or cause marketing across Islamic companies.

Design/methodology/approach

An experimental survey of Iranian university students was conducted to investigate the customer satisfaction, loyalty and purchase intention with companies using social marketing methods such as corporate social responsibility along with cause marketing and cause-related marketing. A total of 400 usable surveys were obtained in SRBIA University of Tehran, while possessing the greatest ability to consume more hoteling services companies and mobile producers beyond Iranian students.

Findings

The results indicated that through an experimental research by including social marketing in products or service companies such as mobile producers and hotel services companies in Iran (as an Islamic country), there are same levels of loyalty and repurchase intentions, but different levels of customer’s satisfaction. Furthermore, the authors found out there is no significant difference regarding the effect of cause marketing and cause-related marketing on loyalty and repurchase intentions. Also, it is different on customer’s satisfaction given the company type.

Research limitations/implications

The sampling frame for this research was limited to students in one of Iran capital city universities. The results are not exactly generalized to all the populations for Iranian product or service consumers. Also, the sampling methods used in this research might have generated bias due to time and resources constraints. So, it is recommended for future studies to consider broader samplings more than university students and beyond only the consumers of international product or service companies.

Originality/value

No study has used corporate social responsibilities to explain customer satisfaction while providing cause marketing and cause-related marketing as corporate social marketing in service companies influencing the customer loyalty and repurchase intentions.
An improved INS/PDR/UWB integrated positioning method for indoor foot-mounted pedestrians
Authors: Fan Qigao , Jia Jie , Pan Peng , Zhang Hai , Sun Yan
Published: November 2018

Purpose

The purpose of this paper is to relate to the real-time navigation and tracking of pedestrians in a closed environment. To restrain accumulated error of low-cost microelectromechanical system inertial navigation system and adapt to the real-time navigation of pedestrians at different speeds, the authors proposed an improved inertial navigation system (INS)/pedestrian dead reckoning (PDR)/ultra wideband (UWB) integrated positioning method for indoor foot-mounted pedestrians.

Design/methodology/approach

This paper proposes a self-adaptive integrated positioning algorithm that can recognize multi-gait and realize a high accurate pedestrian multi-gait indoor positioning. First, the corresponding gait method is used to detect different gaits of pedestrians at different velocities; second, the INS/PDR/UWB integrated system is used to get the positioning information. Thus, the INS/UWB integrated system is used when the pedestrian moves at normal speed; the PDR/UWB integrated system is used when the pedestrian moves at rapid speed. Finally, the adaptive Kalman filter correction method is adopted to modify system errors and improve the positioning performance of integrated system.

Findings

The algorithm presented in this paper improves performance of indoor pedestrian integrated positioning system from three aspects: in the view of different pedestrian gaits at different speeds, the zero velocity detection and stride frequency detection are adopted on the integrated positioning system. Further, the accuracy of inertial positioning systems can be improved; the attitude fusion filter is used to obtain the optimal quaternion and improve the accuracy of INS positioning system and PDR positioning system; because of the errors of adaptive integrated positioning system, the adaptive filter is proposed to correct errors and improve integrated positioning accuracy and stability. The adaptive filtering algorithm can effectively restrain the divergence problem caused by outliers. Compared to the KF algorithm, AKF algorithm can better improve the fault tolerance and precision of integrated positioning system.

Originality/value

The INS/PDR/UWB integrated system is built to track pedestrian position and attitude. Finally, an adaptive Kalman filter is used to improve the accuracy and stability of integrated positioning system.
The University Club
Authors: Delbaere Marjorie , Klassen Brooke , Hess Brooklyn
Published: November 2018

Synopsis

The case was written to help students understand the value that a product or service can offer a consumer in terms of helping them accomplish important tasks and overcome obstacles. It is intended to help students understand the link between marketing strategy and different business models.

Research methodology

The case was written after two of the co-authors assisted the organization with developing a marketing strategy and communications plan. The details in the case were gathered through personal interviews with staff as well as document analysis, including marketing documents, financial statements and strategic plans.

Relevant courses and levels

This case is suitable at the undergraduate level in third and fourth year marketing courses or strategy courses where all students have completed, at minimum, an introductory level marketing course. It can also be used in graduate-level business administration courses that focus on marketing strategy and positioning.
Vodafone-Idea merger: emergence of a telecom giant amidst predatory price wars
Authors: Kittilaksanawong Wiboon , Kandaswamy Sinduja
Published: November 2018

Synopsis

The Indian telecom market was witnessing a fierce price war, especially from an aggressive entry of a new player Reliance Jio Infocomm Limited (Jio) with a predatory pricing strategy. To react to the increasingly intense rivalry and maintain top positions, the second and third largest telecom operator like Vodafone India and Idea Cellular Limited (Idea) decided to merge together. The combined entity would become the largest wireless carrier in India. Was the merger the right competitive strategy for Vodafone India and Idea to fight against the wars? What synergies could the merger bring about? Given Vodafone India and Idea agreed to maintain their respective brands after the merger, would the two brands compete and cannibalize each other’s market share? As the Indian telecom industry was undergoing the liberalization of airwaves, how should the merged entity overcome potential regulatory hurdles? If this mega merger went through, what could be the impacts on the Indian telecom industry? If not, how should the companies move forward with the competition?

Research methodology

This case study research is based on published information of the focal companies and their operating environment. The case is written in such a way that can be depicted by related theoretical perspectives available from leading journals and books. There is no disguise of any actual persons or entities and no personal relationship between the authors and the organizations or individuals mentioned in the case.

Relevant courses and levels

The case study is intended for senior undergraduate and graduate level business school students in courses, including mergers and acquisitions, competitive strategies, industry analysis and marketing strategies.

Theoretical bases

The case is grounded on the industrial organization and resource-based theories, where the actions and reactions of competitors in the market are driven by their awareness, motivation and capability toward the competitive situation. Leveraging on a highly competitive and consolidated, unique Indian telecom market, the authors analyze competitive situations of the industry, evaluate potential synergistic benefits and market power from the merger of competitors, and give recommendations for the merged entity to overcome regulatory hurdles in the industry that is undergoing deregulation and to move forward with effective strategies to compete and strengthen market positions in such industry environment.
Board diversity and stakeholder management: the moderating impact of boards’ learning environment
Authors: Fernandez Whitney Douglas , Thams Yannick
Published: November 2018

Purpose

This paper aims to draw on insights from team learning theory and stakeholder theory to examine the influence of board composition on firms’ stakeholder management practices. The authors posit that board diversity is likely to enhance stakeholder management by shaping organizational goals by placing emphasis on the interests of a wide variety of stakeholders and providing firms with relevant knowledge to enhance their ability manage these interests. The authors further theorize on the moderating role of boards’ learning environment, which they conceptualized as an important complementary governance-related factor, likely to further boards’ ability to enhance stakeholder management.

Design/methodology/approach

The authors test these predictions using the generalized estimating equations (GEE) technique on a panel of S&P 500 firms observed from 2001 to 2011.

Findings

The findings provide evidence that more diverse boards in terms of gender, nationality and race/ethnicity are generally associated with more effective stakeholder management. Further, the findings also suggest that boards’ co-working experience moderates the relationship between gender and national diversity and stakeholder management.

Originality/value

While corporate governance research surveys many strategic implications of board composition, limited attention has been paid to the interplay of board characteristics with stakeholder management. This study is among the first to the authors’ knowledge to explore the impact of board diversity on stakeholder management using team learning research, thus drawing attention to the role of boards’ co-working experience in shaping their ability to impact firms’ outcomes.
The mechanics of predator–prey interactions: First principles of physics predict predator–prey size ratios
Authors: Portalier Sébastien M. J. , Fussmann Gregor F. , Loreau Michel , Cherif Mehdi
Published: November 2018

Robust predictions of predator–prey interactions are fundamental for the understanding of food webs, their structure, dynamics, resistance to species loss, response to invasions and ecosystem function. Most current food web models measure parameters at the food web level to predict patterns at the same level. Thus, they are sensitive to the quality of the data and may be ineffective in predicting non‐observed interactions and disturbed food webs. There is a need for mechanistic models that predict the occurrence of a predator–prey interaction based on lower levels of organization (i.e. the traits of organisms) and the properties of their environment.

Here, we present such a model that focuses on the predation act itself. We built a Newtonian, mechanical model for the processes of searching, capturing and handling of a prey item by a predator. Associated with general metabolic laws, we predict the net energy gain from predation for pairs of pelagic or flying predator species and their prey depending on their body sizes.

Predicted interactions match well with data from the most extensive predator–prey database, and overall model accuracy is greater than the allometric niche model.

Our model shows that it is possible to accurately predict the structure of food webs using only a few mechanical traits. It underlines the importance of physical constraints in structuring food webs.

A plain language summary is available for this article.
Functional responses of avian frugivores to variation in fruit resources between natural and fragmented forests
Authors: Quitián Marta , Santillán Vinicio , Bender Irene M. A. , Espinosa Carlos Iván , Homeier Jürgen , Böhning‐Gaese Katrin , Schleuning Matthias , Lena Neuschulz Eike
Published: November 2018

Partner choice in species interaction networks, that is, between frugivorous birds and fruiting plants, is largely determined by matching of functional traits. However, the composition of functional traits in plant communities changes along land‐use gradients. Understanding how flexible consumers react to changes in the trait composition of resources is crucial to project consequences for ecosystem functions, such as seed dispersal.

We investigated the ability of birds to consume fruits with different sets of traits in natural and fragmented tropical montane forests across an elevational gradient. We developed a novel, trait‐based approach to quantify the functional shifts of consumers between resources with different functional traits. We expected the degree of functional shifts to be associated with bird traits related to food choice, such as bill width and degree of frugivory, as well as foraging behaviour, such as wing shape and foraging stratum.

We sampled the plant–frugivore networks at three elevations and two habitat types (natural and fragmented forest) and measured the functional traits for each plant and bird species. We calculated the trait space of the plant community at each elevation and projected the interacting birds into it. Finally, we calculated the functional shift, which is the trait‐based distance between the preferred fruit resources in the two habitat types for each bird species.

We found differences in the functional trait space of the fruiting plant community between natural and fragmented forests across all elevations. Birds' observed functional shifts between habitat types at each elevation were generally larger than the shifts expected by null models. Wing shape was the most important trait related to the functional shifts across the elevational gradient, whereas bill width, degree of frugivory, foraging stratum and phylogeny were not important.

We conclude that birds with pointed wings respond flexibly to changes in the trait composition of fruit resources, probably due to the high mobility of these species. Our results emphasize that linking species interaction networks and functional trait analyses yield new insights into how consumer species respond to changes in biotic factors and can improve projections of how human impacts modify trophic interactions and associated ecosystem functions.

A plain language summary is available for this article.
Population responses of farmland bird species to agri‐environment schemes and land management options in Northeastern Scotland
Authors: Daskalova Gergana N. , Phillimore Albert B. , Bell Matthew , Maggs Hywel E. , Perkins Allan J.
Published: November 2018

The decline of farmland birds across Europe is a well‐documented case of biodiversity loss, and despite land stewardship supported by funding from agri‐environment schemes (AES), the negative trends have not yet been reversed.

To investigate the contribution of AES towards farmland bird conservation, we compared abundance of five farmland bird species across 13 years and 53 farms (158 farm years = AES, 72 farm years = non AES) in Northeastern Scotland (UK), a region with relatively mixed farmland.

Between 2003 and 2015, on both AES and control farms, skylark (Alauda arvensis) showed a nonsignificant decline, and tree sparrow (Passer montanus) and yellowhammer (Emberiza citrinella) nonsignificant increases, whereas reed bunting (Emberiza schoeniclus) and linnet (Carduelis cannabina) populations remained relatively stable.

We did not detect a significant association between AES and avian abundance or population trends for any of these species, but there were positive associations with some AES management options.

Possible explanations for the lack of a significant AES‐bird abundance association include poor uptake of the best AES options for farmland birds, suboptimal implementation, spill‐over effects from AES onto control farms, and the relatively good state of farmland habitats outwith AES in Northeastern Scotland.

Synthesis and applications. We documented a weak effect size of participation in agri‐environment schemes on farmland bird abundance. We therefore recommend future monitoring studies be designed after consulting a power analysis. Among different land management options, we found that species‐rich grasslands, water margins, and wetland creation enhanced breeding bird abundance, highlighting the importance of relatively undisturbed herbaceous or grassland vegetation for farmland conservation.
Combining optimization and simulation modelling to measure the cumulative impacts of prescribed fire and wildfire on vegetation species diversity
Authors: Chick Matthew P. , York Alan , Sitters Holly , Di Stefano Julian , Nitschke Craig R.
Published: November 2018

Growth‐stage optimization (GSO) offers a new approach to biodiversity conservation in fire‐prone regions by estimating the optimal distribution of vegetation growth stages that maximize a species diversity index. This optimal growth‐stage structure provides managers an operational goal explicitly linked to a positive conservation outcome but does not define the fire regime needed to achieve it.

We paired GSO with LANDIS II, a landscape succession and disturbance simulation model, to (a) estimate the optimal growth‐stage structure that maximized vegetation diversity in a south‐east Australian heathy woodland, (b) define the fire regime needed to achieve it, and (c) determine the cumulative effects of different fire‐regime scenarios on vegetation diversity over a 60‐year period. Scenarios included 0%, 2%, 5%, and 10% of the landscape burnt per year by prescribed fire only, or in combination with three alternative wildfire regimes. Furthermore, we investigated the differences in the optimal growth‐stage structure relating to above‐ground, soil seedbank, and total (above and soil seedbank) diversity datasets.

The growth‐stage structure that maximized total vegetation diversity comprised approximately even proportions of all stages. In contrast, separately analysed above‐ground and soil seedbank data resulted in a greater proportion of younger and older growth‐stages, respectively.

Scenarios including 5% prescribed burning per year (with and without wildfire) resulted in diversity values within 1.5% of the theoretical maximum value. Scenarios including 2% and 10% prescribed fire resulted in diversity values 8%–12% and 1.5%–5% lower than the maximum, respectively. Scenarios without prescribed fire caused diversity to fall 30%–70%. Trends across the 60 years showed that wildfire depressed diversity and subsequent prescribed fire drove recovery within 15 years. The largest threat to vegetation diversity was the absence of fire.

Synthesis and applications. Combining growth‐stage optimization and simulation modelling is a powerful way of defining a conservation‐based fire management goal and identifying the prescribed fire regime needed to achieve it. We demonstrated that vegetation diversity in heathy woodland was increased by prescribed fire, with and without the cumulative effect of wildfire, and declined sharply when fire was excluded. Our method provides a flexible platform for developing long‐term fire management strategies that seek to balance human safety and biodiversity conservation. Including both plants and animals in GSO will help land managers meet the needs of multiple taxa.
Biogeographical scenarios modulate seagrass resistance to small‐scale perturbations
Authors: Tuya Fernando , Fernández‐Torquemada Yolanda , Zarcero Jesús , del Pilar‐Ruso Yoana , Csenteri Ina , Espino Fernando , Manent Pablo , Curbelo Leticia , Antich Adriá , de la Ossa José A. , Royo Laura , Castejón Inés , Procaccini Gabriele , Terrados Jorge , Tomas Fiona
Published: November 2018

Seagrasses constitute a key coastal habitat world‐wide, but are exposed to multiple perturbations. Understanding elements affecting seagrass resistance to disturbances is critical for conservation. Distinct biogeographical scenarios are intrinsically linked with varying ecological and evolution backgrounds shaped across millennia.

We addressed whether the resistance (change in shoot abundances) and performance (change in leaf morphology and growth) of the seagrass Cymodocea nodosa to a local stressor, light reduction, varied across three regions (Southeast Iberia, the Balearic Sea, and the Canaries) within the temperate northern Atlantic realm. We hypothesized that distinct biogeographical scenarios, in terms of distinct ecological/environmental conditions and genetic diversity of meadows, would affect seagrass resistance and performance, with flow‐on effects on associated epifauna. The same experiments, in terms of shading intensities, timing and duration, were replicated at three seagrass meadows within each region.

Results demonstrated inter‐regional variation in the resistance and performance of C. nodosa. Under moderate and high shading, shoot abundance was abruptly decreased, relative to controls, in the Canaries with concurrent, but less accentuated, changes in leaf morphology and no changes in growth. In the other two regions, however, moderate and high shading had a negligible effect on shoot abundance, leaf morphology, and growth. Shading had no overall effect over the total abundance and assemblage structure of epifauna; these faunal attributes, however, varied between regions. Low seagrass resistance at the Canaries is linked with the peripheral distribution of the species there, favouring isolation and decreased genetic diversity.

Synthesis. Different biogeographical scenarios shape seagrass resistance to local perturbations. From a conservation perspective, if resistance differs among biogeographical scenarios, universal conservation rules for seagrasses are challenging.