bluuebunny/crossref_metadata_2025 huggingface dataset:
Agave mapisaga aqueous extract shows in vitro and in vivo activity on murine prostate cancer cells
Authors:   Universidad Nacional Autonoma de Mexico, Hernandez-Peralta Pablo , Garcia-Espejo David A ,   Universidad Nacional Autonoma de Mexico, Gracia-Mora Maria I ,   Universidad Nacional Autonoma de Mexico, Velasco-Velasquez Marco A ,   Universidad Nacional Autonoma de Mexico, Cobos-Marin Laura ,   Universidad Nacional Autonoma de Mexico
Published: September 2022

Plants are a source of multiple antineoplastic treatments. However, the effect of many species used in traditional medicine has yet to be demonstrated. In this work, the taxonomic identification of Agave mapisagawas made and a high-performance liquid chromatography-mass spectrometry (HPLC-MS) study suggested the presence of the aglycone hecogenin, which is part of compounds such as agavoside C and cantalasaponin 4. The antineoplastic activity of an aqueous extract was tested in vitroand in vivoon PEC-Src epithelial murine prostate cancer cells. In vitrostudy revelead a significant chemosensivity at 0.125mg/100μL(p=0.0001). Also, in in vivo, using an isotransplantation model with 1x106cells subcutaneously, it was observed that the group treated with 50 mg/kg presented a lower tumor implantation compared with the control without treatment (p=0.04).
Use and conservation of medicinal plants obtained from agroecosytems and ecosystems by the Mochó and Kakchikel ethnic groups of southeastern Chiapas, México
Authors:   Colegio de Postgraduados, Trigueros-Vazquez Imna Yolanda , Ruiz-Rosado Octavio ,   Colegio de Postgraduados, Gallardo-Lopez Felipe ,   Colegio de Postgraduados, Solis-Guzman Blanca Flor ,   Universidad Autonoma de Chiapas, Morales-Trejo Fredy ,   Universidad Autonoma Chapingo, Lopez-Romero Gustavo ,   Colegio de Postgraduados
Published: September 2022

Even though the ethnic groups Mochó and Kakchikel of the Sierra Mariscal, Chiapas, Mexico, have formal medical services, they still preserve and use medicinal plants. This research had the aim to identify their conservation practices, by using ethnographic and ethnobotanical methods with direct interviews, participatory observation and a questionnaire; furthermore, a Jaccard ́s similarity index for plant species was estimated. Both groups (97% each) use medicinal plants for various reasons and obtain them mainly from their agroecosystems. Within the Kakchikel territory, 53% are native plants, 43% introduced, while 4% does not have a report; within the Mochó territory 56% are native plants and 44% introduced ones. The similarity index showed 0.33 of shared taxonomic species within both territories (33 out of 131 of total). The Kakchikel use more conservation practices than the Mochó ethnic group, to have their medicinal plants ready available, mainly from their agroecosystems.
Phytochemical and biological study of phenolic components from Geoffroea decorticans stem bark
Authors:   Consejo Nacional de Investigaciones Cientificas y Tecnicas, Pastoriza Ana C , Sgariglia Melina A ,   Universidad Nacional de Tucuman, Soberon Jose R ,   Universidad Nacional de Tucuman, Sampietro Diego A ,   Universidad Nacional de Tucuman
Published: September 2022

The stem bark of Geoffroea decorticans(Gill.ex Hook. etArn.) Burk. was used medicinally to cure several skin affections; however, phytochemical and biological antecedents were not found. Analyses of purified methanolic extract from G. decorticansbark (PFGB), realized by silylation derivatization for GC/MS, C18-CC and HPLC followed by two-dimensional TLC and UV-Vis spectroscopy, allowed to characterize nine phenolic compounds, among these, two methoxy flavonoids. Antibacterial assays of PFGB showed the highest activity (MICs= 125 μg/mL) against Staphylococcus aureus(25923) and Enterococcus faecalis(29212) ATCC strains. Moreover, PFGB showed the highest intracellular antioxidant activity at low concentration (5 μg/mL), evaluated by using the fluorescent DA-H2DCF probe on lymphocyte culture; cytotoxic effects on lymphocytes activated or not by LPS were not observed, through Trypan Blue Exclusion and MTT colorimetric assays.The results obtained from the ethnomedicinal approach of this work contribute to the scientific validation of the vulnerary medicinal use of G. decorticans.
A method for structural reliability analysis of trusses with interval uncertainty of random variables
Authors:   Vologda State University, Soloveva A.A. , Inkov A.E. ,   Vologda State University, Solovev S.A. ,   Vologda State University
Published: September 2022

The article describes a method for the reliability analysis of hinge-rod systems (trusses) with an interval estimation of the variability limits of random variables. In practical tasks of structural reliability analysis, it is often not possible to obtain complete statistical data that is necessary for a probabilistic and statistical approach in accordance with GOST 27751-2014. The use of alternative theories of data analysis makes it possible to obtain a define assessment of reliability with incomplete statistical data without introducing unconfirmed hypotheses about the form and shape of probability distribution functions of random variables. In this paper, it is proposed to use data on the limits of variability of random variables (an interval analysis) to assess the reliability of hinge-rod systems on the truss example. A comparative analysis of the truss reliability is given by two approaches (the classical probabilistic-statistical and the proposed interval approach). By the interval approach, the reliability of the truss is lower due to the fact that the interval estimation takes into account other possible distributions within a given interval that differ from the normal probability distribution. In the case when it is impossible to determine the type of probability distribution, but the limits of variability for random variables are known, the use of the presented method is a more cautious for the safety of truss operation.
Formula for calculation of the deflection of a flat strut bridge with an arbitrary number of panels
Authors:   National Research University “MPEI”, Kirsanov M.N.
Published: September 2022

The problem of finding an analytical solution to the problem of deflection of a planar model of a bridge truss with two fixed hinged supports is posed. Formulas are derived for the dependence of deflection, reactions of supports and forces in characteristic rods on the number of panels in the structure. Maple computer mathematics operators are used. The deflection is sought by the Maxwell-Mohr formula. A series of individual solutions obtained for trusses with a successively increasing number of panels are generalized to an arbitrary number of panels. A picture of the distribution of forces on the truss rods is obtained. It is shown that the change of force signs in the truss chords does not depend on its geometrical parameters, but depends only on the number of panels.
MÉTODOS LÚDICOS CREATIVOS EN EL PROCESO DE ANIMACIÓN A LA LECTURA EN ENTORNOS VIRTUALES
Authors:   Universidad San Gregorio de Portoviejo, Briones-Cevallos Karla-Esther , Vélez-Villavicencio Carlina
Published: September 2022

The development of creative playful methods in the process of encouraging reading in virtual environments is a priority process that benefits and contributes to the acquisition of skills and abilities of children in initial education from the representative theoretical aspects of Montessori. , Reggio Emilia, Condemarín among others. In the present study, the objective was to analyze the benefits of creative playful methods of encouraging reading in the virtual environments of children from initial education centers in the canton of Portoviejo, Ecuador. Through reliable theoretical sources, which enriched the study of the variables. The research design was based on a quantitative, bibliographical, exploratory approach, applying the survey instrument aimed at teachers and parents; in addition to an interview with an expert in encouraging reading in early childhood. The research population was made up of parents or representatives, directors and teachers of initial education centers. When identifying the application of creative playful methods in virtual environments that teachers have, it was possible to determine that the vast majority know and apply them, but work should be done so that a significant achievement is reached in the application of said methods in the classroom. virtual context of initial education posing an important challenge in the development of skills and abilities of boys and girls.
Educación de postgrado para fisioterapeutas en el Ecuador
Authors:   Pontificia Universidad Católica del Ecuador, Rosas-Mora Mónica
Published: September 2022

The purpose of this paper is to examine the offer of postgraduate programs for the area of ​​physiotherapy in Ecuador in order to show the status and sufficiency of it. Costs, modality, duration of the offer and location are reviewed. At the same time, it analyzes the reality of the academic training of physiotherapists. The sample used to carry out the study consisted of 100 physiotherapists. Measurements and interventions to obtain data consisted of a survey. It is shown that the universities that offer these programs require more projection and follow-up regarding the positioning of these professionals in the face of the demands of the national and global environment.
LAS POTENCIALIDADES DE LOS NEXOS ENTRE LOS OBSERVATORIOS JURÍDICOS Y LAS UNIVERSIDADES PARA LA INVESTIGACIÓN Y LA DOCENCIA
Authors:   Universidad Laica Vicente Rocafuerte, Pérez-Leyva Carlos-Manuel , Franco-Cortázar Cristina-Elizabeth , García-Lara María-Elena
Published: September 2022

The Organization of American States (OAS), in 2015, published the book called: Public Policy Observatories in the Americas, a guide for their design and implementation in our public administrations (Organization of American States, 2015). Said manual highlights the importance of the creation of legal observatories for the transmission of knowledge, through the dissemination of studies, statistics and publications that achieve the unification of cases and the exchange of experiences, with the purpose of generating in the viewer a vision criticism and analysis of reality that makes it a protagonist, contributing to society in the execution of ideas and projects, duly supported by the analyzes that one or more observatories have provided. In this sense, it is a challenge, typical for these times, of digital transformation and access to massive information, to potentiate the figure of legal observatories in universities, cradles of scientific research. For this reason, this article has as a substantial purpose to explain the main characteristics of the existing observatories in national and international universities and to justify their relevance for the academy, both in strengthening research and in improving teaching and education of citizens. The methodology used in this research work is of a qualitative approach with an explanatory character, since it seeks to offer a look at the different current legal observatories to discover the inherent elements and principles that guide these knowledge centers. In this way, it will be possible, from the deductive method, to prioritize the need to establish a link between legal observatories and universities in the paradigm of scientific-academic research.
Nivel de fragilidad en adultos mayores a través del test de Barber: Caso Clínica Integral Universitaria
Authors:   RED PANAMGERO, Flores-Cerqueda Sergio , Castañeda-Colin Adilene ,   Secretaría de Desarrollo Social del Gobierno del Estado de México, De Jesús-Madero Ana-Karen
Published: September 2022

This study addresses the categorization of frailty in the elderly at the Clínica Integral Universitaria, from a gerontological approach, proposing a new tool for its classification. In addition to analyzing and evaluating the situation in which the patient finds himself, proposing alternatives to provide a better quality gerontological intervention and establish a multidisciplinary work, strengthening the bonds of brotherhood as health professionals. According to the results of the investigation, frailty will become a problem for the elderly population, so the following intervention tools are proposed that will allow the gerontologist to take the appropriate measures to improve the patient's quality of life. The main purposes are to promote research and for the result to be a proposal that serves as a basis for future work on the subject of frailty in the elderly, as well as to encourage our students to reflect their own identity as professionals, expanding their panorama of the area of study and work.
The Managerial Enforcement of Covid-19 Protocols of Faculty of Education Students in Enugu State University of Science and Technology, Agbani, Nigeria
Authors: Elechi Catherin Nkiru , Oboqua Ekpenyong David , Ukwuaba Loretta Chika , Odenigbo Veronica Ngozi
Published: September 2022

This study investigated the managerial enforcement of Covid-19 protocols of faculty of education students in Enugu State University of Science and Technology, Agbani, Nigeria. Three research questions were formulated. Descriptive survey research design was adopted for the study. It samples the study was 689 respondents selected from the ten departments of faculty of Education using simple and accidental random sampling techniques. The instrument used for the study was 26-items, modified likert scale type questionnaire titled “Managerial Enforcement of COVID-19 protocols and Faculty of Education Questionnaire (MECPFEQ)” was used for data collection. the instrument was dully validated by experts and its reliability method. Data collected were analysed using mean scores and standards deviation. The findings from the results revealed that there is a great extent in the university management enforcement of Covid-19 protocols in the study area. Based on the findings, it was recommended among other that there should be regular supervision of all staff, students, visitors, task force and security personnel to ensure that there is consistent compliance to prescribed laws for quality service delivery.
Implementation of Educational Policy for Socio – Economic and Political Emancipation in Nigeria
Authors: Adesua Veronica Olubunmi
Published: September 2022

: The study examined the influence of the implementation of Nigerian Educational Policy on socio – economic and political emancipation in Nigeria. It specifically examined how the implementation of the policy could socially, economically and politically assist in the emancipation of people i.e. the Nigerian citizens. The study revealed that educational policies in Nigeria are capable of making an average Nigerian, self – reliant economically and socially. It further revealed that proper implementation of the policy could improve the political awareness and participation of the citizens. It was concluded that Nigerian educational policy paved way for socio-economic and political emancipation; however, effective and proper implementation brings development to Nigeria. Educational policies in Nigeria should be tailored to suit the social, economic and political aspirations of Nigerians. The problems militating against effective implementation of educational policies were highlighted. Based on the conclusions of the study, it was recommended that the challenges facing the effective implementation of educational policies should be addressed by government and all stakeholders. Since teachers are the implementers of educational policies, qualified teachers should be employed, trained and retrained on how to implement national educational policy in such a way that socio – economic and political emancipation would be achieved. Policy makers and educational experts need to work together to design national policies that would give way to economically self – reliant citizens, they need to work as partners in progress with teachers to ensure that the policy is implemented accordingly, also the cultural backgrounds of all ethnic groups in Nigeria should be taken into consideration whenever educational policies are reviewed.
Tentative SWOT Analysis on Business Leadership in China’s Greater Bay Area
Authors: Yan LI
Published: September 2022

This paper serves as a wake-up call for business leaders in China’s newly established Guangdong-Hong Kong-Macao Greater Bay Area to review their strengths, weaknesses, opportunities, and threats (SWOT) for them to survive and succeed in a volatile environment. The survey used in the study was intended to examine the impact of such factors as leadership traits and personal dispositions including the cultural heritage of Confucianism in business settings. In addition, it was devised to find out whether foreign language skills matter in this regard. Subsequently, companies and institutions are called upon to establish a mechanism to cultivate a talent pool and identify potential leaders in this area.
ANALYSIS OF HEPATITIS B TRANSMISSION POTENTIAL IN THE FAMILY OF PATIENTS USING HBsAg RAPID SCREENING TEST
Authors: M.Kes Dr Laksmyn Kadir , Setiawan I Made Ari
Published: September 2022

Hepatitis B virus (HBV) is the cause of liver disease, found in human body fluids such as saliva, vaginal fluids, semen, and blood. HBV can be transmitted through sex, sharing syringes, baby-mother intercourse, and touching involving bodily fluids. The novelty of this study is that it analyzes the potential for hepatitis B transmission using the HBsAg Rapid Screening Test. The purpose of this study was to analyze the potential for transmission of hepatitis B to the families of patients with patients. This research uses a quantitative method with a descriptive type. The examination used was the immunochromatographic method on venous blood samples of 22 families. The results of the study showed that there were households where one member was detected as HBsAg positive, and 18 other households were HBsAg negative. Transmission of Hepatitis B Virus (HBV) in the family is as much as 9.09% with the family status of parents and children. It is suspected that children who contracted HBV were the result of close contact that lasted for quite a long time, which allowed HBV particles to move. Moreover, the child lives in the same house with the mother, who takes care of him. The conclusion of this study is that the patient's family who has close contact with hepatitis B sufferers can be infected with hepatitis B.Keywords: Virus; Hepatitis B; Immunochoromatography.
ANALYSIS OF OCCUPATIONAL STRESS ON NURSES IN TOTO KABILA REGIONAL GENERAL HOSPITAL
Authors: Nurfadillah Ayu Rofia , S. Lalu Nur Ayini
Published: September 2022

Nursing is a very stressful job because a nursing service provider has a longer duration with patients and is required to provide quality services quickly, precisely, and carefully in complex circumstances or conditions. In addition, nurses are often burdened with other additional tasks and often carry out activities that are not their functions, such as handling administration, finance, and others. Nurses have higher stress levels than other professionals in hospitals. The novelty of this study is because it examines work stress on nurses at TOTO KABILA Hospital. The purpose of this study was to analyze work stress on nurses at Toto Kabila Hospital. The research design used a cross-sectional design, with a research sample of 116 nurses. Analysis of the data used is the chi-square test. The results showed that nurses who had a less heavy workload and experienced moderate work stress were 17 respondents (54.8%) and those who experienced severe work stress were 14 respondents (45.2%). At the same time, nurses with a heavy workload and moderate work stress are 22 respondents (25.9%), and among experts with serious work stress, as many as 63 respondents (74.1%). For good interpersonal relationships, 2 respondents (9.1%) experienced work stress, and 20 respondents (90.9%). Meanwhile, interpersonal relationships that experienced moderate work stress were 37 respondents (39.4%), and severe work stresses 57 respondents (60.6%). The conclusion is that there is a relationship between the workload and interpersonal relationships of nurses with the work stress of nurses at Toto Kabila Hospital, with a value of 0.05. Suggestions are expected that the nurses of RSUD Toto Kabila can manage their working time well, use time effectively in order to complete their work on time, and can find the best solution for every problem faced so as to reduce the workload that results in work stress.
De otras revistas
Authors: Luis Aida
Published: September 2022

De otras revistas
Disparidad en la provisión de servicios de salud
Authors: Vargas Pedro
Published: September 2022

Para algunos, “el final del orden liberal traería el caos, su continuación, significaría el sufrimiento económico inacabable” La polarización conceptual no se queda allí, frente a las realidades que cada día se dan en los 5 continentes. Entregarle todo al mercado, no lleva al bienestar, sino que lo frustra. El mercado necesita de la rectoría del Estado con responsabilidad social.
La disponibilidad de servicios, atención de la enfermedad, la promoción de la salud, la mortalidad por enfermedades, la optimización de los estándares de vida, en las democracias socialistas, está íntimamente ligada a la promoción de los derechos humanos; en los autoritarismos, a la no observación de esos derechos, a la capitalización de la ciudadanía, al secuestro de la sociedad civil por el partido único.
Desafío diagnóstico
Authors: Levy Zafrani Jacqueline
Published: September 2022

Paciente femenina de 1 año de edad con antecedentes de síndrome de Down, hipotiroidismo congénito y leucemia mieloide aguda (LMA), que se presenta en la consulta externa con lesiones cutáneas nodulares eritematosas, algunas blandas y otras firmes, no dolorosas ni pruriginosas en brazo y piernas. Se encuentra en quimioterapia activa en fase de consolidación, siendo su última hospitalización 2 semanas previas por neutropenia profunda y fungemia asociada a catéter venoso central (CVC) por Candida tropicalis. Fue tratada 42 días con antifúngicos y retiro de catéter, con hemocultivos negativos antes de su egreso. Actualmente se encuentra recibiendo sus últimas semanas de quimioterapia ambulatoria para entrar en remisión. Hemograma sin neutropenia.

Resto del examen físico sin hallazgos relevantes, paciente afebril y de buen ánimo, cardiopulmonar bien, abdomen con leve hepatomegalia.

Se realiza ultrasonido abdominal con hallazgo de múltiples lesiones hipoecoicas hepatoesplénicas.
Is [Y/Mg] a Reliable Age Diagnostic for FGK Stars?
Authors: Berger Travis A. , van Saders Jennifer L. , Huber Daniel , Gaidos Eric , Schlieder Joshua E. , Claytor Zachary R.
Published: September 2022

Current spectroscopic surveys are producing large catalogs of chemical abundances for stars of all types. The yttrium-to-magnesium ratio, [Y/Mg], has emerged as a candidate age indicator for solar twins in the local stellar neighborhood. However, it is unclear whether it is a viable age diagnostic for more diverse stellar types, so we investigate [Y/Mg] as an age indicator for the FGK-type planet host stars observed by Kepler. We find that the [Y/Mg] “Clock” is most precise for solar twins, with a [Y/Mg]/age slope of m = −0.0370 ±0.0071 dex Gyr−1 and σ
Age = 2.6 Gyr. We attribute the lower precision compared to literature results to nonsolar twins contaminating our solar twin sample and recommend a 1.5 Gyr systematic uncertainty for stellar ages derived with any [Y/Mg]–Age relation. We also analyzed the [Y/Mg] Clock as a function of T
eff,

log
g

, and metallicity individually and find no strong trends, but we compute statistically significant [Y/Mg]–Age relations for subsamples defined by ranges in T
eff,

log
g

, and metallicity. Finally, we compare [Y/Mg] and rotation ages and find statistically similar trends as for isochrone ages, although we find that rotation ages perform better for GK dwarfs while isochrones perform better for FG subgiants. We conclude that the [Y/Mg] Clock is most precise for solar twins and analogs but is also a useful age diagnostic for FGK stars.
Three-dimensional Magnetothermal Simulations of Magnetar Outbursts
Authors: De Grandis Davide , Turolla Roberto , Taverna Roberto , Lucchetta Elisa , Wood Toby S. , Zane Silvia
Published: September 2022

The defining trait of magnetars, the most strongly magnetized neutron stars (NSs), is their transient activity in the X/γ-bands. In particular, many of them undergo phases of enhanced emission, the so-called outbursts, during which the luminosity rises by a factor ∼10–1000 in a few hours to then decay over months/years. Outbursts often exhibit a thermal spectrum, associated with the appearance of hotter regions on the surface of the star, which subsequently change in shape and cool down. Here we simulate the unfolding of a sudden, localized heat injection in the external crust of an NS with a 3D magnetothermal evolution code, finding that this can reproduce the main features of magnetar outbursts. A full 3D treatment allows us to study for the first time the inherently asymmetric hot spots that appear on the surface of the star as the result of the injection and to follow the evolution of their temperature and shape. We investigate the effects produced by different physical conditions in the heated region, highlighting in particular how the geometry of the magnetic field plays a key role in determining the properties of the event.
NuSTAR Observations of Intrinsically X-Ray Weak Quasar Candidates: An Obscuration-only Scenario
Authors: Wang Chaojun , Luo B. , Brandt W. N. , Alexander D. M. , Bauer F. E. , Gallagher S. C. , Huang Jian , Liu Hezhen , Stern D.
Published: September 2022

We utilize recent NuSTAR observations (co-added depth ≈55–120 ks) of PG 1001+054, PG 1254+047, and PHL 1811 to constrain their hard X-ray (≳5 keV) weakness and spectral shapes and thus to investigate the nature of their extreme X-ray weakness. These quasars showed very weak soft X-ray emission, and they were proposed to be intrinsically X-ray weak, with the X-ray coronae producing weak continuum emission relative to their optical/UV emission. However, the new observations suggest an alternative explanation. The NuSTAR 3–24 keV spectral shapes for PG 1001+054 and PHL 1811 are likely flat (effective power-law photon indices

Γ

eff

=

1.0

−
0.6

+
0.5

and

Γ

eff

=

1.4

−
0.7

+
0.8

, respectively), while the shape is nominal for PG 1254+047 (Γeff = 1.8 ± 0.3). PG 1001+054 and PHL 1811 are significantly weak at hard X-ray energies (by factors of ≈26–74 at rest-frame 8 keV) compared to the expectations from their optical/UV emission, while PG 1254+047 is only hard X-ray weak by a factor of ≈3. We suggest that X-ray obscuration is present in all three quasars. We propose that, as an alternative to the intrinsic X-ray weakness + X-ray obscuration scenario, the soft and hard X-ray weakness of these quasars can be uniformly explained under an obscuration-only scenario. This model provides adequate descriptions of the multiepoch soft and hard X-ray data of these quasars, with variable column density and leaked fraction of the partial covering absorber. We suggest that the absorber is the clumpy dust-free wind launched from the accretion disk. These quasars probably have super-Eddington accretion rates that drive powerful and high-density winds.
Plaskett’s Star and Its Environment
Authors: Davidge T. J.
Published: September 2022

Astrometric information from GAIA DR3 is used to examine the environment around the massive binary system Plaskett’s Star (PS). PS is found to be embedded in a stellar grouping that has distinct kinematic and spatial distributions. Based on the characteristics of these neighboring stars, it is suggested that PS may have formed during the earliest phases of star formation in the neighboring cluster NGC 2244—if so, then PS likely has an age in excess of ∼5 million years.
Efficacy of Alendronate in Preventing Periprosthetic Bone Loss after Implantation of a Primary Hip Endoprosthesis
Authors: Shabani Ilir , Samardziski Milan , Kamnar Viktor , Atanasov Nenad , Bogojevska-Doksevska Milena , Popovska Danica , Belchishta Anila
Published: September 2022

Total hip arthroplasty (THA) is now the gold standard for the surgical treatment of coxarthrosis. The appearance of bone loss after implantation of the hip endoprosthesis over time reduces the primary stability of the implant and leads to progressive looseningof the implant, or periprosthetic fracture, which are considered to be the most common causes of hip revision.
The aim of this study is to evaluate the value of alendronate application in reducing periprosthetic osteolysis reduction after implantation of total cementless hip endoprosthesis.
The study analyzed 50 patients operated on with implantation of a cementless total hip arthroplasty (THA). The first group of 25 patients recieved oral alendronate, calcium and vitamin D3 postoperatively. The second group of 25 patients were examined and followed postoperatively without any therapy.
Patients were examined by RTG and DXA methods at 6, 12 and 18 months.
The study showed a difference in the values of bone mineral density (BMD) and bone mineral content (BMC) in the interval of 6,12 and 18 months, using the DXA method.
Alendronate therapy after total hip implantation reduces periprosthetic bone loss, maintains  bone mineralization and strengthens the implant
Do Tumor Locations and Stages at Diagnosis Predict the 5-Year Survival Outcome in Patients with Colorectal Cancer?
Authors: Niam Muhammad S. , Nastiti Novia Ayuning , Dradjat Respati S. , Rudijanto Achmad , Sujuti Hidayat
Published: September 2022

BACKGROUND: Globally, colorectal cancer (CRC) ranks as the third most common cancer. CRC cases are generally discovered at a more advanced stage, so the patients’ life expectancy is low. The prognostic factors that affect the survival outcome in CRC patients are still limited.

AIM: This study aimed to identify factors associated with the 5-year overall survival of CRC patients at Dr. Saiful Anwar Regional General Hospital, Malang.

MATERIALS AND METHODS: This study used a retrospective cohort design and obtained data from patients diagnosed with CRC at Dr. Saiful Anwar Regional General Hospital Malang between January and December 2015. The 5-year prognosis factors, tumor clinical characteristics, disease progression, and demographic details were analyzed using Kaplan Meier and Cox regression.

RESULTS: Kaplan–Meier analysis showed differences in the survival function based on surgery (p = 0.028) and stages (p = 0.002). There were no differences in the survival function based on gender (p = 0.455), age (p = 0.484), tumor location (p = 0.114), carcino embryonic antigen (0.459), histopathology (p = 0.842), tumor recurrence (p = 0.268), chemotherapy response (p = 0.06), and response description (p = 0.086). Based on the Cox proportional hazard regression, the tumor stage was the only variable that affected the risk of mortality (p = 0.014) with an HR value of 3.500 (CI 95%).

CONCLUSION: The tumor stage is a significant predictor of survival, suggesting that higher stages may require more attention and more aggressive treatment than lower stages.
Alternatives of Risk Prediction Models for Preeclampsia in a Low Middle-Income Setting
Authors: Kusuma Raden Aditya , Nurdiati Detty Siti , Wilopo Siswanto Agus
Published: September 2022

Abstract
Objectives:  To  develop prediction models for the first-trimester prediction of PE (PE) using the established biomarkers including maternal characteristics and history, mean arterial pressure (MAP), uterine artery Doppler pulsatility index (UtA-PI ), and Placental Growth Factor (PlGF)) in combination with Ophthalmic artery Doppler peak ratio (PR).
Methods:  This was a  prospective observational study in women attending a first-trimester screening at 11-14 weeks’  gestation. Maternal characteristics and history, measurement of MAP, ultrasound examination for UtA-PI measurement, maternal ophthalmic PR Doppler measurement, and serum  PlGF collection were performed during the visit. Logistic regression  analysis was used to determine if the maternal factor had a significant contribution in predicting PE. The Receiving Operator Curve (ROC) analysis was used to determine the area under the curve  (AUC), positive predictive value  (PPV), negative prefictive value (NPV) and positive screening cut-off in predicting the occurrence of PE at any gestational age.
 
Results: Of the 946 eligible participants, 71 (7,49%) subjects were affected by PE. Based on the ROC curves, optimal high-risk cutoff value for prediction of preeclampsia at any gestational age for model 2 (primary care model) in this Indonesia study population were 63% with the sensitivity and specificity of 71.8% and 71.2%, respectively. Both sensitivity and specificity for model 3 (complete model) were 70.4% and 74.9%, respectively for the cutoff value 58%. The area under the curve of model 2, model 3 was 0.7651 (95% CI: 0.7023-0.8279)) and 0.7911 (95% CI: 0.7312-0.8511), respectively, for predicting PE. In addition, PPV and NPV for model 2 were 16.8% and 96.9%, respectively. PPV and NPV for model 3 were 18.55 and 96.9%, respectively.
 
Conclusion: The prediction models of preeclampsia vary depending upon healthcare resource. Complete model is clinically superior to primary care model but it is not statistically significant.  Prognostic models should be easy to use, informative and low cost with great potential to improve maternal and neonatal health in Low Middle Income Country settings.
Quand l’aspiration à la démocratie passe par les signes écologiques : le cas de l’Iran et de la résistance par les chiens
Authors: Salimikouchi Ebrahim
Published: September 2022

En Iran d’aujourd’hui, on est le témoin des partis pris environnementaux solidaires et d’autres repères moins visibles d’une période d’activisme éco-politique. Un activisme dans lequel on cherche malgré tout la responsabilité de construire ensemble un espace meilleur. La participation de gens dans les enjeux de cette écorésistance démontre que ce mouvement s’esquisse de plus en plus pour une nouvelle défense de la vie, de la liberté, de la polyphonie. On y cherche une société plus favorable à une démocratie participative et délibérative. Cette nouvelle prise de conscience se consolide surtout grâce à la présence des femmes avec leurs « couleurs », « chiens » et « bicyclettes ». Ignorée, dépréciée ou moquée par le système économique et politique, cette présence écologique est révélatrice d’un souci patient et civil pour devenir inaliénable. Des fragments visuels de cette présence s’accumulent et donnent une intensité sémiotique à l’expérience d’être là et de rester sensible. Une jeune femme qui traverse la rue avec sa bicyclette ou tenant un petit chien contre elle, est une sorte d’autoportrait d’une revendication socio-politique. Sa présence graphique et responsable est avant tout annonciatrice de la possibilité d’intervenir autrement et avec une nouvelle allure transformante. Fondé sur une approche sémiotico-phénoménologique, l’article présent étudie la révolution de ces signes écologiques envahissant l’espace public et résistant contre l’emprise de toutes nouvelles formes de l’autoritarisme.
La politique chez Kant : une doctrine du droit appliquée
Authors: Rimoux Frédéric
Published: September 2022

La conception de la politique de Kant suscite aujourd’hui des débats controversés. Elle est souvent perçue comme hostile à l’expérience, dédaigneuse de la prudence, et peu ouverte à la faculté de juger, lorsqu’elle n’est pas contestée dans son existence même. Prolongeant les efforts de réhabilitations entrepris ces dernières années, nous soutenons au contraire que la théorie de la politique comme « doctrine du droit appliquée » occupe une place essentielle dans la philosophie pratique de Kant en assurant le passage des purs principes de droit dans la réalité. Cette fonction de médiation, qui affirme la réalisabilité de l’idéal, en même temps que sa fragilité, évite deux écueils également funestes, celui d’une absorption de la politique dans la morale et le droit, et celui de son autonomie. La conciliation hiérarchisée à laquelle elle parvient entre propositions déontiques et considérations conséquentialistes, nous semble pouvoir éclairer encore les débats contemporains.
Pour sortir de l’impasse
Authors: Gago Verónica , Bousenna Youness
Published: September 2022

L’intellectuelle et activiste argentine Verónica Gago analyse la brutalité du néolibéralisme avec un prisme féministe qui en révèle la violence jusque dans l’intime. En écho à son essai La Puissance féministe (Divergences, 2021), elle cerne deux tendances accentuées par la crise liée à la pandémie : une prédation financière sur les plus précaires grâce à une logique d’endettement croissant, qui justifie ensuite leur exploitation toujours plus poussée par le travail. Par-delà sa force analytique, le féminisme offre aussi des moyens d’action pour une remise en cause profonde de cet ordre, avance Verónica Gago membre du collectif anti-féminicide Ni Una Menos (« Pas une de moins »), qui défend la grève comme outil privilégié de transformation radicale.
Pour sortir de l’impasse
Authors: Le Brun Annie , Armanda Juri
Published: September 2022

À partir de la récente vente à prix d’or d’une œuvre d’art numérique, Annie Le Brun et Juri Armanda poursuivent leur réflexion sur les images et leur accaparement par le capital entamée dans Ceci tuera cela (Stock, 2021). Ladite œuvre, assemblage de cinq mille images, incarne une production du rien révélatrice de ces nouveaux « marchés du vide » créés par le capitalisme actuel qui, du « zéro émissions » au « sans gluten », colonisent tous les pans de notre vie. À cette nouvelle éthique de consommation pseudo-écologique, les deux essayistes opposent la beauté inappropriable de la nature, en laquelle ils appellent à puiser une force de liberté pour résister à l’asservissement marchand.
El Decreto sobre las Restricciones del hierro en la edificación. La norma olvidada
Authors: Pons-Poblet Josep Maria , Arboix-Alió Alba
Published: September 2022

En el año 1936, se inició en España uno de los periodos más luctuosos de su historia reciente; la Guerra Civil. La contienda, que duró hasta el 1 de abril de 1939, conllevó un abundante número de muertos y heridos, así como una destrucción generalizada. Finalizada ésta, el régimen se encontró con la tarea de la reconstrucción nacional. Este hecho implicaba la utilización de unos recursos materiales que, en muchos casos, eran difíciles de obtener. Fuere el caso de los materiales férricos. Con la finalidad de regular el empleo del hierro en las construcciones, en julio de 1941 el Gobierno de la Nación aprobaría el Reglamento sobre las restricciones del hierro en la edificación. Los técnicos responsables tuvieron que implementar sus obras teniendo presente estas restricciones impuestas. Año 2021. Ochenta años después el presente trabajo rememora la génesis, las principales disposiciones así como las consecuencias que conllevaría esta norma.
Les cartes géologiques du département de Loire-Inférieure
Authors: Rétif Pascal
Published: September 2022

La cartographie géologique de détail commence en France au début du XIXe siècle avec les cartes départementales, œuvres d’érudits locaux et d’ingénieurs des mines. La Loire-Inférieure a ainsi été cartographiée successivement par le premier conservateur du Muséum de Nantes, François-René Dubuisson (1763-1836) en 1832, puis par un ingénieur des mines, Joseph Durocher, en 1854 (inédite) et finalement en 1861 par Frédéric Cailliaud (1787-1869) successeur de Dubuisson au Muséum. L'étude de ces trois cartes successives d'un même département permet de discuter leurs conditions d’élaboration et de préciser les discours géologiques de leurs auteurs.
La logique d'une enquête historique : étude d'un manuscrit inédit de Jean-Etienne Guettard sur la formation des coquilles dans les montagnes
Authors: Crépin-Obert Patricia
Published: September 2022

Le plaisir de l’historien des sciences réside parfois dans la découverte d’une archive inattendue, non pas celle d’une idée visionnaire ou d’une expérience cruciale mais celle des errements d’une pensée préscientifique dans l’histoire de la géologie. C’est le cas d’un manuscrit du fonds ancien de Jean-Étienne Guettard au Muséum d’histoire naturelle de Paris. Il consiste en une réponse aux Singularités de la nature de Voltaire (1768). L’enquête historique a déroulé le fil d’une controverse sur l’origine des fossiles au cœur des montagnes. L’intérêt historique par la notoriété des deux académiciens est certain. Mais au-delà, l’étude épistémologique révèle la tension entre la construction d’un problème paléontologique et la récurrence d’obstacles épistémologiques, illustrant le pouvoir du questionnement et de l’argumentation. Nous démontrons combien les arguments mobilisés par les deux protagonistes mettent en opposition le factuel obtus de Guettard et l’heuristique abusive de Voltaire. La caution de l’empirisme dans la démarche des naturalistes du XVIIIe siècle est reconsidérée.
In the Beginning was a Strike. Undocumented Workers’ Strikes and the Appropriation of Conflictual Routines
Authors: Zougbédé Emeline
Published: September 2022

On the basis of ethnographic research into the case of four strikes between 2017 and 2019, this article examines the labour strikes of undocumented workers, supported and organised by the Confédération générale du travail (CGT). For a long time, these strikes appeared to be “improbable mobilisations”. This article aims to shed light on them by revealing the extent to which they stem from the appropriation of conflictual routines. The strikes delineate an institutional landscape that integrates the issue of undocumented workers into an economic, social and regulatory framework, by putting it on the trade union and political agenda. While removing certain obstacles to the collective protest for undocumented workers, the appropriation of conflictual routines allows the accumulation of activist resources, and the opening of spaces of negotiation. Thus, the recent labour strikes by undocumented migrants appear less improbable and more characteristic of strategic action, in the absence of genuine labour migration policies.
Bundled Bispectral Index Monitoring and Sedation During Paralysis in Acute Respiratory Distress Syndrome
Authors: Abraham Sunitha , Lussier Bethany L.
Published: September 2022

Background

Clinical assessments of depth of sedation are insufficient for patients undergoing neuromuscular blockade during treatment of acute respiratory distress syndrome (ARDS). This quality initiative was aimed to augment objective assessment and improve sedation during therapeutic paralysis using the bispectral index (BIS).

Methods

This quality improvement intervention provided education and subsequent implementation of a BIS monitoring and sedation/analgesia bundle in a large, urban, safety-net intensive care unit. After the intervention, a retrospective review of the first 70 admissions with ARDS assessed use and documented sedation changes in response to BIS.

Results

Therapeutic neuromuscular blockade was initiated for 58 of 70 patients (82.8%) with ARDS, of whom 43 (74%) had BIS monitoring and 29.3% had bundled BIS sedation-titration orders. Explicit documentation of sedation titration in response to BIS values occurred in 27 (62.8%) of those with BIS recordings.

Conclusions

BIS sedation/analgesia bundled order sets are underused, but education and access to BIS monitoring led to high use of monitoring alone and subsequent sedation changes.
An Interprofessional Approach to Mobilizing Patients With COVID-19 Receiving Extracorporeal Membrane Oxygenation
Authors: Sheasby Jenelle , Krais Suzanne , Do Monica , Hall Amy , Pace Holland , Myers David P. , George Timothy J.
Published: September 2022

Objective

To assess survival outcomes with the intervention of an interprofessional mobilization program for patients with COVID-19 who were receiving venovenous extracorporeal membrane oxygenation (VV-ECMO).

Design

Preintervention and postintervention retrospective cohort study.

Methods

Survival outcomes of nonmobilized, adult patients (n = 16) with COVID-19 who were receiving VV-ECMO (May 2020 through December 2020) were compared with those of 26 patients who received a mobility care plan (January 2021 through November 2021). In the preintervention group, full sedation and paralysis were used. In the postintervention group, an early mobilization strategy involving interprofessional collaboration was introduced.

Results

The postintervention group had improved survival (73.1% vs 43.8%; P < .04); fewer days of receiving paralytics, fentanyl, and midazolam (P < .01 for all); but more days of dexmedetomidine, morphine, and ketamine administration (P < .01 for all). Concomitantly, more patients in the postintervention cohort received oral or transdermal analgesics, oral anxiolytics, and oral antipsychotics (P < .01 for all), and also required more VV-ECMO cannula adjustments (P = .03).

Conclusion

Early mobilization of patients with COVID-19 who were receiving VV-ECMO improved survival rates but led to more cannula adjustments.
Effect of oral premedication of midazolam, ketamine, and dexmedetomidine on pediatric sedation and ease of parental separation in anesthesia induction for elective surgery
Authors: Zarei Aref , Modir Hesameddin , Mahmoodiyeh Behnam , Kamali Alireza , Zamani-Barsari Farzad
Published: September 2022

Objective:

To compare effect of midazolam, dexmedetomidine, and ketamine as oral premedication on pediatric sedation and ease of parental separation anxiety in anesthesia induction.

Methods:

This multicenter, prospective, randomized, double-blind, clinical trial focused on a pediatric population aged 2-7 years (n=153) with the American Society of Anesthesiologists I-II who required elective surgery. The patients were stratified into three intervention groups: midazolam, ketamine, and dexmedetomidine. Hemodynamic parameters (blood pressure, heart rate, and oxygen saturation) every 5 min until induction of anesthesia along with non-hemodynamic factors, comprised of sedation score before the administration and at the time of being separated from the parents, as well as parental separation anxiety scale, acceptance of anesthesia induction, and side effects were recorded and compared.

Results:

No statistically significant difference in oxygen saturation, heart rate, blood pressure, duration of surgery, time to achieve an Aldrete score of 9-10, or sedation score was noted in the study groups. More patients in the dexmedetomidine and midazolam groups could better ease parental separation anxiety than the ketamine group (P=0.001). Moreover, fewer patients accept anesthesia induction (P=0.001) and more had side effects in the ketamine group (P=0.047).

Conclusions:

Our findings indicate that compared to the ketamine group, dexmedetomidine and midazolam are better in easing parental separation anxiety and accepting induction of anesthesia with fewer side effects. Dexmedetomidine and midazolam may be considered better choices. However, the final choice hinges on the patient's specific physical condition and the anesthesiologist's preference.

Clinical registarion:

This study is registered in the Iranian Registry Clinical Trial center with the clinical trial code of IRCT20211007052693N1.