bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge, attitude and practice towards Hepatitis B infection of people in part of Jigawa State, Nigeria
Authors: Yakudima Ismaila Ibrahim , Magaji Yunusa , Abdulkarim Ishaq Aliyu
Published: May 2022

This study analyzed Knowledge, Attitude/Perception and Practice of the people toward hepatitis B infection in four local governments of Ringim Emirate, Jigawa State. The data were obtained using questionnaire instrument and organized and processed in SPSS version 20 and analyzed using descriptive statistics and inferential statistics. The result shows that very few (4.9%) people showed good level of knowledge of the infection, and only very few (3.4%) show knowledge of good practice. The result also shows correlation coefficient of 0.917 indicated a positive correlation between knowledge scores. The findings also revealed that there is no statistically significant different between educational level and knowledge of Hepatitis B (p=.336). However, there is statistically significant difference, (p=.000) among other items of socio- demographic characteristics. The study suggested that public health education is needed to improve knowledge, attitude and practice on hepatitis B. Implementation of community mass media health education programme to raise the awareness and the knowledge about hepatitis B using all forms of media especially radios. Health care providers who are involved in the hepatitis control programme need to set schedule to provide education, increase awareness of contact case screening, early identifying and treating hepatitis infection especially hepatitis B. This will help to in prevention and controlling of the infection.
Estimation of time independent Cox proportional hazard model with correlated unordered categorical covariates
Authors: Onatunji Adewale Paul , Olalude Oladapo Ayokomi , Oladimeji Luqman Abiola
Published: May 2022

Many studies have been carried out since the development of Cox model(1972). Little or no attention on the performance of Cox model with correlated unordered categorical data exists in literature. The paper is aimed at investigating the behavior of the parameter estimates and the model under varied collinearity ( p =0.2, 0.6, 0.9) between discrete independent variablse. Two discrete independent data were generated using binomial distribution with the considered levels of collinearity for sample size of 10, 30, 100 and 500.Survival time was generated with estimated baseline hazard function. The paper shows that regression coefficients with small standard errors are statistically significant when samplesize is large at low collinearity as against small sample size. There is evidence of non proportional hazard assumptions when there exists collinearity between unordered categorical data. Moreso, Cox model is statistically significant at all levels of collinearity considered for varied sample size except when sample size is 30 in the study.
Evaluation of Land use and Land Cover Changes in the Gold Mining Enclaves of Zamfara Sahel, Nigeria
Authors: Ado S.J. , Ejidike B.N. , Adetola B. , Olaniyi O.E.
Published: May 2022

Understanding land use and land cover changes and their underlying dynamics is critical to land reclamation and biodiversity management in mining enclaves and deceleration of desertification in the vast Zamfara Sahel of Northwestern Nigeria. This paper presents a quantitative analysis of land cover changes in the gold mining enclaves of Anka, Bukkuyum and Maru Local Government Areas in Zamfara State, Nigeria. Data were aggregated from field trips, remote sensing and geographical information system technologies and archives. Data and satellite images from three time periods of 1987, 2002 and 2020 were used for the analysis. The images were captured on yearly degradation rates of LULC classes within 100m, 200m and 300m of protected areas. Five LULC classes were identified and twenty-five transition classes were mapped out using GIS technology. Analysis shows bare ground/ built-up/rock outcrop LULC class expanded as mining activities had deleterious impacts on the land cover of the enclaves.
Effect of Boiling, Oven Drying and Roasting On the Proximate Composition and Microbial Loads of Cane Rat
Authors: Adebowale T.K. , Akintunde O.A. , Oduntan O.O. , Fakunle K.B.
Published: May 2022

The study examined the effect of proximate composition, mineral and microbial loads of cane rat (Thryonomys swindarianus) meat of different processing methods. Three (3) live adult cane rats were purchased from reputable cane rat domestication farm in Abeokuta and transported to the wildlife laboratory of the Federal University of Agriculture where the samples were slaughtered and subjected roasting, boiling and oven drying. Small piece of each processed cane rat meat was extracted and placed in sterile plastic containers for proximate, mineral and microbial loads for three (3) consecutive days. The standard procedure described by Holt et al., (1994) method was used for the analysis of moisture content, crude protein, total available carbohydrate and ash. Data obtained were subjected to analysis of variance using least significant difference to separate the means and line graph was used for the microbial count. The results showed that from day 1 to day 3 oven dried meat had the highest ash, F. extract, C. protein and C. fat content compared with other processing methods. In the same vein, high potassium, iron and magnesium content was recorded in oven dry cane rat. Furthermore, there are presence of Staphylococcus aureus, Bacillus spp, Salmonella spp and Escherichia coli in the meat samples which can cause serious health problems. To encourage sustainable utilization of bush meat consumption in urban and rural areas, oven dried bush meat is the most appropriate method of processing, this should be used and encourage by the seller.
Norcantharidin alleviates cyclophosphamide induced immunosuppression and leukopenia in mice through NF κB pathway
Authors: Wang Guochuan , Zhou Xiaolu , Yang Mei , Ma Xiaoyu , Liu Xin
Published: May 2022

Purpose: To investigate the effect of norcantharidin (NCTD) on cyclophosphamide (CY)-induced immunosuppression and leukopenia in mice.

Methods: Cyclophosphamide (80 mg/kg/day) was intraperitoneally administered to mice from day 1 to 3 and day 9, and from day 4 to 10, NCTD (1, 2 and 4 mg/kg) was intraperitoneally administered. The counts of white blood cells (WBC), red blood cells (RBC) and platelets (PLT) in peripheral blood were determined, followed by the evaluation of mouse spleen and thymus indices. Histopathological examination was performed using hematoxylin-eosin (H & E) staining. In addition, the serum levels of immunoglobulins and cytokines were determined using enzyme-linked immunosorbent assay (ELISA), while plenetic T lymphocyte subsets were assessed by flow cytometry. The expression levels of p65, p-p65, IκBα, and p-IκBα in spleen tissues were determined by immunoblotting.

Results: Administration of NCTD (1, 2 and 4 mg/kg) increased blood cell counts, and alleviated injuries on splenocytes and thymocytes in CY-treated mice, accompanied by decline in spleen and thymus indices. NCTD ameliorated CY-induced immunosuppression by inhibiting the cytokines but increased the immunoglobulins. CD4+ and CD8+ T lymphocyte expressions were enhanced, especially at the high dose of NCTD (4 mg/kg). Besides, NCTD at high doses (2 and 4 mg/kg) significantly activated NF-κB pathway.

Conclusion: Administration of NCTD alleviates CY-induced leukopenia and immunosuppression in mice through activation of NF-κB pathway, thus providing a lead for the potential treatment of chemotherapy-induced leukopenia and immunosuppression.
Effect of amifostine on pulmonary contusion from blunt chest trauma in rats
Authors: Acıpayam Ahmet , Eser Nadire , Yaylalı Aslı Eryılmaz , Tülüce Kerim , Yoldaş Atilla , Tolun Fatma İnanç
Published: May 2022

Purpose: To investigate the efficacy of different doses of amifostine (AMI) and dexamethasone (DXM) on bilateral pulmonary contusion in rats.

Methods: Forty-two Sprague Dawley rats were divided into six groups of seven animals each (control, pulmonary contusion (PC), PC + AMI 400 mg/kg, PC + AMI 200 mg/kg, PC + AMI 400 mg/kg + DXM, and PC + DXM-treated groups). RelAssay commercial kit was used to determine total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) activity associated with blunt trauma induced pulmonary damage were determined by enzyme-linked immunosorbent assay (ELISA). Blood gas was determined using a blood gas analyzer, while histopathological examinations were performed on the tissues by hematoxylin and eosin (H & E) staining method.

Results: Significant improvement in biochemical parameters and histopathological findings were observed in the groups treated with dexamethasone and high-dose amifostine (400 mg/kg; p < 0.05). However, low-dose amifostine (200 mg/kg) and a combination of dexamethasone with amifostine (400 g/kg) was ineffective in balancing the biochemical changes due to trauma (p > 0.05).

Conclusion: High-dose amifostine combined with dexamethasone mitigates trauma-induced damage in rat by preventing the elevation of key inflammatory markers. Further preclinical and clinical studies are required to determine the efficacy of amifostine in humans and to compare its activity with other agents.
KLK4 affects the biological behavior of oral squamous cell carcinoma through Wnt/β catenin and PI3K/Akt signaling pathways
Authors: Fang Yihong , Ouyang Qiming , Zheng Zhi , Wang Jin
Published: May 2022

Purpose: To investigate the effect of kallikrein 4 (KLK4) on oral squamous cell carcinoma (OSCC), and its mechanism of action.

Method: Human tongue SCC cell line TCA-8113 was cultured, and the interference fragment and irrelevant sequence fragment of KLK4 gene were designed and synthesized. These fragments were constructed into pgcsi-h1 plasmid. Then, the TCA-8113 cells were cultured for 24 h, followed by transfection, after which TCA-8113-NC and TCA-8113-siKLK4 cells were obtained. The mRNA expression of KLK4 was determined using quantitative real-time-polymerase chain reaction (PCR). Proliferative potential was assessed using MTT method, while apoptosis was determined by flow cytometry. Furthermore, cell migration was evaluated by scratch test, and Transwell cell invasion experiment was used to determine cell invasion. Immunoblot assay was applied to determine the expressions of E- and N-cadherins, vimentin, uPA, Wnt1, β-Catenin, p-pi3k and p-Akt.

Result: Compared with TCA-8113-nc, the expression of KLK4 in TCA-8113-siKLK4 cells was significantly down-regulated, while, relative to TCA-8113-NC, TCA-8113-siKLK4 cells had significantly reduced cell proliferation, invasion and migration, and enhanced apoptosis (p < 0.05). Moreover, there was significant up-regulation of E- and N-cadherins, vimentin, uPA, Wnt1, β-Catenin, p-pi3k and p-Akt in TCA-8113-siKLK4 group, relative to TCA-8113-NC (p < 0.05).

Conclusion: KLK4 enhances the multiplication, metastasis and invasive potential of OSCC cells, but suppresses apoptotic changes via activation of Wnt/β-catenin/PI3K/Akt signal route. The potential of Kallikrein-4 as biomarker for OSCC cells should be determined in suitable animal models.
Determination of allyl isothiocyanate from Hedyotis herbacea and its in silico screening for wound healing activity
Authors: Babu K Anand , Sivakrishnan S , Jasemine S
Published: May 2022

Purpose: To determine the bio-active constituents from the chloroform leaf extract of Hedyotis herbacea, and the wound healing activity of its phytoconstituents.

Methods: A gas chromatographic-mass spectrophotometer (GC-MS) was used to isolate and characterize the plant’s chloroform extract. In order to verify the effectiveness of the isolated allyl isothiocyanate, it was docked with key enzymes needed for the healing process of wounds, such as p50 NF-κB, Interleukin-6 (IL-6), COX-2, TNF-α, Interleukin-1β, MMP-9, FGF-2, FGF2/FGF2-FGFR1, IGF1R, and TGF-β1 by using AUTODOCK VINA.

Results: The GC-MS isolated and identified 425 compounds in the screened extract, out of which 29 compounds were shown to have significant pharmacological activity. The allyl isothiocyanate compound present in the extract was shown to have the ability to repair skin damage. In silico analysis revealed that allyl isothiocyanate interacts efficiently with the active site of residues of amino acids found in the crucial proteins which are involved in wound healing process.

Conclusion: Hedyotis herbacea contains allyl isothiocyanate, which has wound-healing properties. Other unexplored phytocompounds in the extract might also contribute to the wound-healing activity of the plant. This should be further evaluated in order to access more wound-healing properties of the plant.
Effect of general anesthesia with different doses of remimazolam on the depth of sedation and respiratory function in patients
Authors: Liu Zhijie , Zhao Xing , Chen Yongxue , Gao Yang
Published: May 2022

Purpose: To investigate the effect of general anesthesia using different doses of remimazolam on the depth of sedation and respiratory function in patients.

Methods: From August 2019 to May 2021, 120 patients admitted to Handan Central Hospital for general anesthesia were randomly assigned to propofol group (positive control) given the drug at a dose of 1.5 mg/kg, and three groups were given remimazolam (R) at a dose of 0.2 mg/kg (R1), 0.3 mg/kg (R2), or 0.4 mg/kg (R3) via intravenous injection. relation between Modified Observer Alertness/Sedation Scale (MOAA/S) scores and BIS was determined and recorded for the three remimazolam groups of patients. Systolic blood pressure, diastolic blood pressure, heart rate and oxygen saturation (SpO2) levels were recorded. The Bruggrmann Comfort Scale (BCS) scale [8] was used at 4 score grades to assess the comfort level of the patients.

Results: The Modified Observer Alertness/Sedation Scale (MOAA/S) scores were positively correlated with Bispectral index (BIS); the higher the anesthesia dose, the higher the MOAA/S scores and BIS values of the patients. Patients in groups R1, R2, and R3 had significantly higher systolic blood pressure, diastolic blood pressure, heart rate, and oxygen saturation (SpO2) at T2 than those in the propofol group (p < 0.05). Groups R1 and R2 exhibited considerably greater PAW values at T3 than the propofol group, whereas R3 had significantly lower PAW values at T3. There was significantly more incidence of bradycardia and hypotension in the propofol group than in the other three groups (p < 0.05).

Conclusion: General anesthesia with remimazolam at a dose of 0.3 mg/kg has no effect on respiratory function and hemodynamics, but it produces positive sedation and a high safety profile. However, more clinical trials are necessary prior to its application in clinical practice.
Patients’ satisfaction with treatment using anti rheumatic drugs, and their adherence to medication: A non interventional, cross sectional study among some Chinese outpatients
Authors: Zhang Huying , Gu Yurong , Chen Lu , Zhu Jinwei , Luo Chao , Zhou Weijun
Published: May 2022

Purpose: To determine satisfaction with treatment and adherence to medication amongst Chinese patients with rheumatoid arthritis.

Methods: This cross-sectional study enrolled 398 rheumatoid arthritis (RA) patients who filled out questionnaire during outpatient consultation. The Chinese version of the Treatment Satisfaction Questionnaire (C-TSQM-II) was used to evaluate treatment satisfaction, while the Chinese Compliance Questionnaire for Rheumatology (threshold ≤ 80) and the medication possession ratio (MPR) were used for the assessment of adherence to medication.

Results: In all medications, treatment satisfaction was higher in the mild subgroup and the moderate subgroup than in the severe subgroup (p < 0.05). Treatment satisfaction scores with respect to biological disease-modifying anti-rheumatic drugs (bDMARDs) were significantly lower in patients in the severe subgroup than in those in the moderate subgroup, with respect to convenience and global satisfaction (p < 0.05). Moreover, for bDMARDs therapies, treatment satisfaction was higher in the moderate subgroup than in the severe subgroup in all four areas examined (p < 0.05). The Chinese Compliance Questionnaire score showed that 156 patients (39 %) were adherent to medication, while 242 patients (61 %) were not. Results from MPR indicate that 310 patients (78 %) were adherent to medication, while 68 patients (22 %) were not. In the mild group, 96.5 % of patients were adherent to all medications, and 94.4 % were adherent to bDMARDs. 

Conclusion: Patients were most likely unable to distinguish amongst disease progression, disease-induced damage, and other causes of pain or discomfort. Treatment satisfaction and medication adherence were higher in patients with mild rheumatoid arthritis.
Mesenchymal stem cells facilitate gastric cancer cell growth and oxaliplatin resista nce via upregulation of SMARCA5
Authors: Nie Yongli , Guo Jun , Chen Jun , Wang Yanyan
Published: May 2022

Purpose: To evaluate the role of mesenchymal stem cells (MSCs) in gastric cancer (GC), and reveal its underlying mechanisms.

Methods: Expression of SMARCA5 was quantified in GES-1, AGS and MKN45 cell lines. In MSCs-GC co-cultured cells, cell viability was assessed using cell counting kit-8 (CCK-8) assay, and colony formation were performed to determine cell proliferation. The invasion of the MSCs-GC cells was evaluated by Transwell assay. The levels of vimentin, snail and slug, as well as Wingless-Int (Wnt)/β-catenin related proteins β-catenin, Axin, c-myc, and matrix metalloproteinase (MMP)-7 were determined using immunoblotting. Oxaliplatin was added to GC cells, and the effect of siSMARCA5 on cell sensitivity to oxaliplatin was investigated after transfection with SMARCA5 siRNA into MSCs-GC cells.

Results: SMARCA5 was highly expressed after co-culture with MSCs (p < 0.001). The MSCs facilitated the proliferation of GC cells, and enhanced cell invasion as well as migration (p < 0.001) compared with untreated cells. MSCs also promoted epithelial–mesenchymal transition (EMT) by increasing production of vimentin, snail, and slug (p < 0.001). The MSCs decreased the sensitivity of GC cells to oxaliplatin, while the knockdown of SMARCA5 reversed the effect (p < 0.001). Furthermore, MSCs up-regulated β-catenin, c-myc, and MMP-7 levels, but downregulated Axin expression compared with untreated cells (p < 0.001). However, siSMARCA5 blocked these processes compared with si-NC group (p < 0.001).

Conclusion: MSCs facilitate GC cell growth and oxaliplatin resistance by upregulating SMARCA5 and activating Wnt/β-catenin signaling. This may provide an alternative treatment target for patients with GC.
NR4A1 alleviates the toxicity in neural stem cells induced by propofol in early life by regulating AMPK pathway
Authors: Zhu Miaomiao , Hu Jing , Gao Baofeng , Liu Changlin , Li Huiqing , Zhang Zengzhen
Published: May 2022

Purpose: To examine the association of propofol (PRO) with related key genes that may serve as potential biomarkers for alleviation of PRO-induced toxicity in neural stem cells (NSCs).

Methods: Differentially expressed genes (DEGs) were screened based on GEO database, using the analysis platform of Metaboanalyst, GEO2R, DAVID and Ehbio. NSCs were purchased and treated with 3 μM of propofol (PRO). NR4A1 was transfected into NSCs, and the NR4A1 expression, apoptosis-related protein and AMPK pathway-related protein were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting. Cell viability and apoptosis were evaluated by methylthiazolyldiphenyl-tetrazolium bromid (MTT) assay and flow cytometry.

Results: A total of 278 DEGs were analyzed on GSE106799 microarray, and finally screened for differentially expressed down-regulated gene, NR4A1, which is a hubgene. NR4A1 expression decreased in PRO-induced NSCs. Furthermore, NR4A1 attenuated the PRO-induced decrease in the viability of NSCs and the increase in apoptosis. Moreover, NR4A1 increased p-AMPK/AMPK level.

Conclusion: NR4A1 attenuates the toxicity in NSCs induced by PRO by regulating AMPK pathways, and thus provides a theoretical basis for the treatment of nerve damage caused by anesthetics.
Universal Horn Sentences and the Joint Embedding Property
Authors: Bodirsky Manuel , Rydval Jakub , Schrottenloher André
Published: May 2022

The finite models of a universal sentence $\Phi$ in a finite relational
signature are the age of a structure if and only if $\Phi$ has the joint
embedding property. We prove that the computational problem whether a given
universal sentence $\Phi$ has the joint embedding property is undecidable, even
if $\Phi$ is additionally Horn and the signature of $\Phi$ only contains
relation symbols of arity at most two.
Topographical change assessment of tidal flats in Ha Long - Cam Pha, Quang Ninh using Landsat
Authors: Pham Lan Thi , Tong Son Si , Le Ha Thu Thi , Do Toan Van , Mai Han Ngoc Thi ,   Faculty of Geomatics and Land Administration, Hanoi University of Mining and Geology, Vietnam  University of Science and Technology of Hanoi, Vietnam  Co Do National Resources and Environmental office, Can Tho City, Vietnam  Tan Cuong Construction Consulting and Map Surveying Co., Ltd, Vietnam
Published: May 2022

Assessment of landform change in tidal flat is crucial for ecological environment protection, coastal erosion prevention and development likelihood for local people. Multi-temporal remote sensing images are useful data to detect the change of tidal flat. This study aims to assess intertidal topographic changes by comparing digital elevation model (DEM) from 1988 to 2014. The DEMs were generated from Landsat images from 1988÷1990; 2000÷2001 and 2013÷2014 using the waterline method. Correlation between DEM in 2013÷2014 and field data reached the value R of 0.821. The area variation of tidal flat topography is presented by spatial indicators. (1) the change of area of tidal flat such as high tidal flat, middle tidal flat, and low tidal flat using overlay analysis. (2) volume change of tidal flat were detected by subtraction from DEMs. The area of tidal flat decreased 25.56 ha which shows erosion from 1988÷2001. Overall, 1000m3 of sediment deposited on the high tidal flat was indicated.
Empirical observations of the yield of logs from trees of the boreal region
Authors: Kärenlampi Petri P.
Published: May 2022

The yield of sawlogs and plywood logs from boreal trees is discussed. First, taper curves are used to compute geometric (maximal) sawlog and plywood log contents. Then, a quality reduction is implemented, according to previously published models. Finally, the outcome is verified using empirical observations. Regarding spruce trees, the different estimates of sawlog content agree. In the case of birch and pine trees, the estimates differ. The sawlog and plywood log yield from large trees is greater than prognosticated one, probably due to missing over-aged trees in the empirical data.  The yield of sawlogs and plywood logs from small trees is smaller than prognosticated one, most of the empirical data originating from thinnings with a focus on the quality of the remaining trees. The sawlog content of individual trees from clearcutting displays a skew distribution around the expected value. The distribution in thinning trunks shows a binary component, with a large proportion of trees with zero sawlog content. Keywords: sawlog; plywoodlog; Picea abies; Betula species; Pinus sylvestris
Weight loss of logwood piles stored under winter conditions in Poland
Authors: Jakubowski Marcin , Praczyk Maciej
Published: May 2022

Our work focuses on the natural drying of woods in winter. It aimed to compare the natural drying process of three wood species: Scots pine as coniferous species, sessile oak as ring-porous species with a marked heartwood and silver birch as a sapwood species with a diffuse-porous structure. The research was carried out in central Poland. We collected logs from a 41-year-old stand destined for thinning. We stacked the logs randomly in one pile. The experiment took place between November 30, 2016 and April 4, 2017. All the samples were measured individually every two days throughout the experiment. We found logs lost weight during the experiment, especially pine (12% of total mass), less so oak and birch (7%). We recorded the biggest decrease during the last month (in spring). The wood’s moisture content decreased the most in pine and the least in oak heartwood. The stepwise regression model explains the impact of weather at 58%. Relative humidity was the most significant factor (0.58), followed by temperature and wind. We observed that weight loss and diameter are related to different degrees in the tested species, which probably depends on the sapwood area. Our observations show that natural wood drying in winter is a slow process that speeds up in the spring. Keywords: natural drying, woodpiles, wood storage, moisture content.
Social Practice and the Exchange of Metals and Metallurgical Knowledge in 2nd Millennium Central Asia
Authors: Stöllner Thomas , Gontscharov Anton
Published: May 2022

The current article discusses the Bronze Age metal evidence in Central Asia based on a vast study of metals of Kazakh origin in order to better understand what Chernykh once called the West-Asian-Metallurgical Province (WAMP). Based on typological studies it became obvious that typologies do not sufficiently help to understand the distribution patterns of Bronze Age metals in regard to their social  nor their economic background. The authors therefore propose an anthropological and theoretical approach that allows the  exploration of the practice of exchange within steppe communities based on provenance studies of metals using elemental and Pb-isotope data. These data have been analysed within a research project carried out with Kazakhstan partners between 2004 and 2014.  For the first time, a selection of data are presented that support some of the general interpretations of exchange modes between the  Petrovka Early Bronze Age and the Late Bronze Age. Especially during the second millennium, it seems that the exchange pattern of  metals had changed from single high valued items to a larger scale trade, which included metal transport as well. It is suggested that  although the practice of exchange modes between the steppe communities change to larger scale metal exchange during the 2nd half  of the 2nd millennium BC, most of the social background still remained similar in comparison to the earlier periods.
Educación Socioemocional y Formación Docente
Authors: García Pérez Jorge Luis , Garza Ruíz Bertha Alicia
Published: May 2022

Se presenta un estudio con enfoque cualitativo y bajo una metodología de investigación-acción cuyo objetivo fue diseñar e implementar una estrategia de innovación que favorezca a la formación docente en el área de Educación Socioemocional a través de las redes sociales. El alcance del estudio es exploratorio y correlacional. Se creó una página de Facebook en donde se crearon y compartieron videos de carácter informativo sobre la materia en cuestión. Los videos fueron reproducidos en 15 estados de México con un total de 11,091 reproducciones. Para medir el impacto de la estrategia se implementó un grupo focal con cuatro docentes de un centro educativo de educación primaria, mismo que fue analizado a través de la herramienta Atlas.ti. Se concluye que a través de las redes sociales se pueden implementar estrategias de formación docente y que estas pueden lograr alcance e impacto entre la comunidad educativa.

Abstract

Research is presented containing a qualitative approach under an action research methodology aimed at the design and implementation of an innovation strategy favoring teacher training in the area of socioemotional education by means of social networks. The scope of this study is exploratory and correlational. A Facebook account was created where informative videos on the subject in question were created and shared. The videos were reproduced in 15 states in Mexico with a total of 11 091 reproductions. To measure the impact of the strategy, a focus group was implemented which consisted of four teachers from an elementary school in Nuevo Leon, Mexico. The results were analyzed using ATLAS.ti tool. It was concluded that by means of social networks teacher training strategies can be implemented and may achieve coverage and impact the educational community.
Dondurulmuş Deniz Ürünlerinde Vibrio spp.’nin İlmiğe Dayalı İzotermal Amplifikasyon (Loop Mediated Isothermal Amplification, LAMP) Yöntemiyle Belirlenmesi
Authors: DOĞRUER Yusuf , TELLİ A. Ezgi , TELLİ Nihat , BİÇER Yusuf
Published: May 2022

Bu çalışmada, deniz ürünleri kaynaklı enfeksiyonlarda en yaygın etkenlerden olan Vibrio spp.’nin yüksek risk grubunu oluşturan Vibrio parahaemolyticus, V. vulnificus ve V. cholerae’nın yüksek özgüllük, verimlilik ve hızlılık içeren yeni bir yöntem olan İlmiğe Dayalı İzotermal Amplifikasyon (Loop Mediated Isothermal Amplification, LAMP) yöntemiyle tespit edilmesi amaçlandı.

Araştırma materyali olarak, süpermarketler ve balık hallerinde satışa sunulan dondurulmuş deniz ürünleri (hamsi filetosu, bütün hamsi, dondurulmuş balık köfte, ahtapot, karides, kalamar, akivades midyesi, midye eti, kabuklu midye, uskumru filetosu, sardalya, surimi çubuk, vongole midyesi, çıtır kalamar halkaları, kaya levreği n = 212) toplandı. Klasik kültür yöntemiyle örneklerin izolasyonu için ISO / TS 21872-1: 2007 ve ISO 21872-2: 2007 prosedürleri kullanıldı. Şüpheli izolatlardan DNA ekstraksiyonu gerçekleştirildi. Daha sonra izolatlar Vibrio spp. için gyrB1 gen bölgesinin amplifikasyonu ile genus spesifik PCR reaksiyonu kullanılarak doğrulandı. Pozitif örneklerde turbidite bazlı Real-Time LAMP gerçekleştirildi. Bu amaçla, sırasıyla V. parahaemolyticus, V. vulnificus ve V. cholerae'nin saptanması için toxR, vvHA ve ompW hedef gen bölgeleri için tasarlanmış LAMP primer setleri kullanıldı.

Sonuç olarak, klasik kültür metodu kullanılarak analiz edilmiş 212 (% 16,98) örnekten 36'sının Vibrio spp. ile kontamine olduğu tespit edildi. LAMP reaksiyonu sonuçlarına göre, Vibrio spp. pozitif izolatların içerisinde V. parahaemolyticus ve V. vulnificus'un oranı sırasıyla 13/36 (% 36.1) ve 2/36 (% 5.5) olarak tespit edildi. Analiz edilen örneklerin hiçbirinde V. cholerae tespit edilmedi. Bu bağlamda, dondurulmuş deniz ürünlerinde V. parahaemolyticus ve V. vulnificus gibi patojenik suşların varlığı halk sağlığı açısından riskli olarak kabul edildi.
STUDENT LEARNING MOTIVATION IN ONLINE BASED PHYSICS LEARNING AT SMAN 1 AMANDRAYA
Authors: Buulolo Febrius , Pardede Hebron , Silaban Bajongga
Published: May 2022

Penelitian ini bertujuan untuk mendeskripsikan motivasi belajar peserta didik pada pembelajaran fisika berbasis online sekolah menengah atas negeri 1 Amandraya. Metode penelitian yang digunakan adalah kuantitatif deskriptif dengan populasi seluruh peserta didik dan guru. Sampel penelitian ini terdiri 85 peserta didik dan 2 guru yang dipilih menggunakan teknik purposive sampling. Pengumpulan data penelitian menggunakan angket melalui Google Form dan Whatsapp diberikan kepada 43 item untuk peserta didik dan 15 item untuk guru. Hasil penelitian motivasi belajar fisika peserta didik diperoleh dan dianalisis berdasarkan respon peserta didik dan guru, yaitu pada indikator pada cita-cita dan aspirasi peserta didik tergolong baik, kemampuan peserta didik tergolong cukup baik, kondisi peserta didik tergolong baik,  upaya guru dalam membelajarkan peserta didik tergolong sangat baik, kondisi lingkungan peserta didik tergolong baik, fasilitas belajar peserta didik tergolong cukup baik. Keseluruhan indikator motivasi belajar fisika berdasarkan respon peserta didik dan guru pada pembelajaran fisika berbasis online tergolong baik.
Theoretical approach of oral communication competency
Authors: Alaudinova Dilnoza
Published: May 2022

This article deals with the one of the main language skill oral communication. As we know oral communication is very important for every language learner. So far a lot of methods and ways have been researched by scientists around the world. For the purposes of the general education competency assessment, the oral communication competency involves the ability to ethically and responsibly use verbal and nonverbal communication.
Ўзбекистонда авиация транспорти тарихи (1950–1980 йй.)
Authors: Тўхтабаев Аъзамжон
Published: May 2022

Мазкур мақолада 1950–1980 йилларда Ўзбекистонда авиатранспорт тарихи ёритилган. Унда Иккинчи жаҳон урушидан сўнг фуқаролик авиацияси тизимида амалга оширилган ислоҳотлар манбалар асосида ўрганилди. Кўриб чиқилган давр оралиғида кўплаб маҳаллий ва халқаро ҳаво қатновлари йўлга қўйилганлиги аниқланди. Ҳаво транс-порти орқали йўловчи ва юк ташиш ҳажми ортиб бориши кузатилди. Республика бўйича ҳаво қатновлар йўналиш-лари ва узунлиги бўйича маълумотлар келтирилган. Собиқ СССР бўйича ҳаво транспортида йўловчи ташиш бўйича статистик рақамлар берилди. Шунингдек, қатновларни амалга оширган авиатранспортлар ҳақида маълумот берилган.
Awareness Regarding Diabetes Risk Factors, Prevention and Management among Community Members in Diyala/Baqubah
Authors: Abdul Karim Rania Ayad , Habib Huda Adnan
Published: May 2022

Background: Background: Diabetes mellitus is a life-threatening disease. Global prevalence of diabetes mellitus is increasing rapidly providing a worrying indication and major threat to global health unless interventions are created through community awareness and knowledge regarding different aspect of DM.
Aims: To assess the level of awareness regarding diabetes risk factors, prevention and management among community members in Baqubah city and to identify any association between awareness level and some variables.
Methods: Across sectional study was carried out from the 1st of January - 30th of November 2019 in all primary health care centers (six centers) in center of Baqubah city. A convenient sample of 400 participants who attended the health centers during the study period and eligible to inclusion criteria were included. Data were collected vie direct interview with a structural questionnaire that include personal data, questions regarding knowledge, regard diabetes definition, prevention, risk factor, management and control.
Results: Good diabetes awareness were reported among 50% of studied. A significant statistical association were found between good awareness and age of 20-30years, more than secondary school education, high family income and positive family history of diabetes with the following (52, 34, 35 & 68) % respectively.
Conclusion: Good diabetes awareness was dominant and was significantly associated with middle age group, higher education and positive family history of diabetes. an educational health programs that tackles area of weakness about awareness of diabetes mellitus need to be implemented on the governmental level.
MİMARİ, TEKSTİL, HEYKEL, PERFORMANS: HEIDI BUCHER VE MEKÂNIN TENİ
Authors: Asyalı Büyükerman Fulya
Published: May 2022

Heidi Bucher, 1970’lerde kendisiyle özdeşleşen ‘Skinnings’ adlı heykelleri için mimari mekânların duvarlarında lateks ve kumaş ile kalıplamalar yapan ve bunlardan elde ettiği fragmanları birleştirerek heykele dönüştüren bir sanatçıdır. Bucher’ın sanatı, heykellerin üretim sürecinde hem hassasiyet hem de fiziksel güç gerektiren uygulamaların karşıt yapısı ve performatif yönüyle olduğu kadar, mimari ve beden arasındaki melezliği yansıtan plastik sonuçları ile günümüz sanatında da tekrardan ilgi uyandıran bir güncelliğe sahiptir. Zürih’te Uygulamalı Sanatlar Okulu’nda aldığı tekstil eğitiminin ardından önce ipek baskı kolajlar ve kumaş heykeller yapan Bucher, ABD’ye taşınması sonrası o yıllarda çağdaş sanat eğilimlerinin çeşitliliği içinde, hafıza ve metamorfoz kavramları üzerine çalışarak, performans ve mimari mekâna yönelik müdahale içeren heykellere yönelmiştir. Bucher’ın yapıtları, Alman mimar Gottfried Semper'in (1803-1879), mimarlığın kökeninin dokumada yattığını savunan yazılarında; mimarlığın canlı bir zar, ikinci bir ten olarak işlev gördüğü fikrinden derinden etkilendiğini ortaya koyar. Bucher, mimariyi, tekstili ve teni birleştirerek Semper'in teorilerine atıfta bulunur. Bu heykellerin dokusu ve renkleri lateks malzemenin dönüşümüyle yaşlanan ve deforme olmaya başlayan bir bedeni anımsatır: Esnekliğini bir süre korusa da sonunda koyulaşan, kırışan ve sertleşen lateksin değişen görünümü teni andırır. Tenin; benliği kuşatan bir ev ya da kabuk olduğu metaforundan faydalanan Bucher’ın heykellerinde mimari ve beden arasındaki etkileşimin yarattığı melezlik, sürrealist etkiler taşıdığı gibi malzemenin yapısal özelliklerini kullanması, kırılganlık ve geçiciliği görünür kılması ile postminimal bir tavır da yüklenir. Beden ve mekân arasındaki muğlak alanın tanımına özgün bir yaklaşımı olan Bucher’ın ‘ten duvarlı odalar’ etkisi veren lateks heykelleri, hafızanın izlerini ve malzemenin süreç içinde dönüşümü ile metamorfoz temasını görselleştirir.
Nascar and tourism : Analyses based on a scoping review of the literature
Authors: ROULT Romain , AUGER Denis , SARMIENTO Santiago Alejandro Ortegon
Published: May 2022

Many countries, provinces and cities around the world use major sporting events as a catalyst for tourism development. The National Association for Stock Car Auto Racing (NASCAR), through its championships and racing events, has for many years, chosen to integrate itself into capitalist and neoliberal tourism and economic models. As a motorsport industry with strong historical, economic and media roots in American culture and certain values, NASCAR generates a myriad of tourism impacts on the territories hosting these races. This study, therefore, aims, through a scoping review of the scientific literature, to take stock of the scientific knowledge produced on NASCAR and its tourism impacts. This approach allowed the analysis of 28 scientific articles in depth and to draw several analytical conclusions. First of all, an observation was noted regarding a very strong involvement of sponsors and the media in this industry, which undeniably contributes to the creation of forms of sporting imagery around the teams and drivers). These sporting imaginaries undoubtedly colour the partisan cultures and even the fan communities that are created and evolve around and within this sporting ecosystem. The study of the tourist spin-offs of NASCAR has been studied in the scientific literature but appears to be rather limited or circumscribed, and must, therefore, be widely developed empirically.
The relationship of public investments in science and scientometric indicators from the perspective of Croatian universities
Authors: Rajter Miroslav
Published: May 2022

Aim: This study addresses the hypothesis that the invest-ments in science are positively correlated with the indica-tors of productivity and performance of the universities. Methods: A cross-sectional design was used with the datafrom 27 EU countries. The percentage of GDP invested in science in higher education in 2019 and investments ex-pressed as €/inhabitant were used. The criterion variables were total number of publications in Web of Science for 2020; number of publications categorized as article, review or note (ARN); change in the number of publications com-pared to 2016 in total and for Organisation for Economic Co-operation and Development (OECD) research areas; productivity per inhabitant; productivity per researcher; productivity per researcher in higher education system; and number of Academic Ranking of World Universities (ARWU) TOP1000 universities per inhabitant. Descriptive data and Pearson and Spearman correlations were calculat-ed. Additionally, partial Spearman correlations for detailed examinations were used.Results: Most of the productivity indicators were positivelycorrelated to the investment in science. The absolute invest-ment in science in €/inhabitant is more important than in-vestment expressed as the percentage of GDP. Unexpectedly, the correlations between investments and the growth rate in productivity were negative indicating that the less devel-oped countries have achieved a larger growth in productiv-ity in the examined 5-year period. Conclusion: The results indicate that the investments inscience as the percentage of GDP is important, but the ab-solute amount of money also has an important role in the prediction of scientific productivity. However, since the absolute amount of investments is limited in the less developed countries, they should be more focused on buildingthe strategies that capitalize on specific strengths and potentials. This further accentuates the need for science policychange in Croatia with the strategic focus on aligning the re-sources to the expected results.
Pandemic-activated Psychological Growth: Significance of extraversion, self-consciousness and COVID-19 related anxiety
Authors: Łoś Zbigniew , Żurko Magdalena , Słowińska Aleksandra , Senejko Alicja , Madeja-Bień Kamila
Published: May 2022

Background

The sense of threat to health and life in the face of pandemic, accompanied by difficulties imposed by lockdown, may trigger a serious crisis. Among possible consequences of such a crisis may paradoxically be the phenomenon of psychological growth. The aim of this article is to identify predictors of pandemic-activated psychological growth (PPG). The relationships between extraversion, reflective and ruminative self-consciousness and the PPG were the subject of our inquiry. Additionally, a question was posed about the indirect effect of self-consciousness on the PPG through anxiety.

Participants and procedure

Participants: The study involved 1206 participants aged 18 to 26 years, who declared that the pandemic situation significantly threatens their important life goals.
Procedure: Cross-sectional design. Four online short questionnaire-measures were used: The Ten-Item Personality Inventory (TIPI), The Rumination-Reflection Questionnaire (RRQ), The Current Self-disposition Scale (CSS), and The Post-traumatic Growth Inventory (PTGI).

Results

Extraversion and reflective self-consciousness were direct predictors of higher PPG. Whereas ruminative self-consciousness was directly related to a lower PPG. There was the indirect effect of ruminative self-consciousness on the PPG through the COVID-19 related anxiety.

Conclusions

Although the results do not allow to conclude on the permanence of growth effect, finding the PPG predictors considered as beneficial resources for coping with difficult pandemic circumstances appears to be valuable in the current state of affairs.
Immune and inflammatory cytokines profile in Iraqi patients with acute and chronic myeloid leukemia
Authors: M. J. AL-Khateeb Shatha , Thair Tahir Noor , Al-bayati Ali Abdulateef Hasan
Published: May 2022

Introduction and Aim: Evaluation of the profile of immunological and inflammatory cytokines, IL-6, IL-2 and TNF? in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients compared their level with healthy controls, and assessment of the association of these cytokines with clinical and hematological variables.
 
Patients and Methods: Thirty AML, thirty CML patients, and thirty healthy control individuals were recruited for this study from the National Hematology Center for Research and Treatment in Baghdad for the period of October 2020 to March 2021. Leukemic patients were under chemotherapy. Complete blood picture routine test and cytokines profile test were done. IL-6, IL-2 and TNF-? were quantitatively measured using enzymes linked immunosorbent assay (ELISA) kits.
 
Results: Hematological myeloid cancers affect more males than female, in AML male/female ratio was 17/13 while in CML was 16/14. The range of duration of the disease for both AML and CML was 1-3 years. in both AML group the level of IL-6 59.66 ± 31.99 pg/mL and in CML group 57.07± 16.52 pg/mL were both significantly higher P value < 0.001 than that of control group 37.95± 6.10 pg/mL. TNF? in AML group was significantly higher P value < 0.001 than that of control group. A high significant difference in serum level of IL-2 P value <0.0001 in AML and CML compared to controls.
 
Conclusion: IL-6, TNF? and IL-2 levels were higher in myeloid malignancy groups than controls. Serum cytokines shown to be positively associated with each other and could signify to poor outcome of the myeloid malignancy patients.
Efficacy of herbal medicine for patients with diabetic neuropathies: An updated literature review
Authors: Hutapea Albert Manggading , Simbolon Boyke Marthin
Published: May 2022

Traditional medicine is efficacious to protect complications of diabetes mellitus, such as diabetic neuropathy. Therapy with herbal medicine has been developed for people with diabetes empirically over the years. This literature review aims to assess effect of herbal medicine for patients with diabetic neuropathies. We conducted a literature analysis using articles that were randomized controlled clinical trials (RCTs). Three databases were searched from PubMed, EMBASE, CENTRAL that have been published from January 2000 until October 2021until October 2021 and obtained four articles that met the study criteria. The review analysis results showed a significant effect between Gua Sha therapy, green tea extract, and topical Citrullus colocynthis on reducing diabetic neuropathy pain (p < 0.05). Nutmeg Extracts did not show significant results on diabetes mellitus pain after being treated for four weeks (p = 0.063). The review results in the physical and neural function also showed the significant increase in mean scores. Despite the positive findings, it is too early to conclude on the efficacy of herbal medicine to treat diabetic neuropathy due to the high clinical heterogeneity and the number of sample size  of the study was too small. However, it may be indicative of the effect of herbal medicine in reducing pain in diabetic neuropathy.
Effect of Ayurveda in management of dysbiosis with special reference to Bifidobacterium in children with autism spectrum disorders
Authors: K. S. Dinesh , C. Krishnendhu , Balakrishnan Geethu , Chitra S. Swapna , A. S. Santhi Krishna , M. J. George , Patel Anita
Published: May 2022

Introduction and Aim: The prevalence of autism spectrum disorder has risen in the last two decades. Disruption of homeostasis of several species and genus of bacteria in the gut termed as dysbiosis is having a pivotal role in ASD pathophysiology. Invariable correlations between the behavioral severities of ASD and dysbiosis management have been affirmed through various previous studies. Bifidobacterium make a significant species appraised well in microbial studies linked with ASD. A randomized controlled trial was conducted to assess the efficacy of Ayurveda therapies in improving Bifidobacterial abundance in Autism children.
 
Methodology: The study took place at the VPSV Ayurveda College Kottakkal's outpatient and in-patient units where 60 children with Autism were randomized to two groups. The intervention prolonged 30 days in total, with three rounds of assessment: baseline (0th day), interim (30th day), and final (60thday). Both the test and control groups received conventional multidisciplinary therapies for 60 days and additionally, the test group was given Ayurveda poly-herbal formulations and food and lifestyle instructions for first 30 days. The result was made through GI severity index measurement and 16SrRNA sequencing.
 
Results: After one month of intervention with poly herbal compounds of Ayurveda along with lifestyle guidelines and conventional therapies a statistically significant improvement observed in the relative abundance of Bifidobacterium in intervention group compared to control group.
 
Conclusion: Poly herbal compounds of Vilwadi Gulika and Rajanyadi choornam along with the dietary lifestyle guidelines and multidisciplinary interventions has played a big role in improving Bifidobacteria in autistic children.