bluuebunny/crossref_metadata_2025 huggingface dataset:
Usefulness of Kaloderm® in Finger Tip Necrosis : A Case Report
Authors: Yoon Chung-Min , Lee Seung Cheol , Choi Ji-An
Published: January 2022

We experienced a case of crush injury of the hand for which we performed a flap surgery and treated the necrotic parts placement using cultured allogeneic keratinocytes (Kaloderm®) with good results.

The patient was a 31-year-old woman whose left middle finger was caught in a door, causing a crush injury. Although primary repair was performed, a 2 × 2.5-cm-sized necrosis developed, and a V-Y advancement flap was performed after the removal of dead tissues. However, a 1 × 2-cm-sized partial necrosis occurred and was treated using Kaloderm®.

After the use of Kaloderm®, the patient’s wound was healed, and no complications, except for mild pain, were observed for 1 year after the surgery.

If a necrotic site appears after flap placement of fingertip, its treatment is difficult. If used well, Kaloderm® may be a good option for necrosis of the fingertips and other areas that are difficult to cure.
The Roles of Human Endogenous Retroviruses (HERVs) in Inflammation
Authors: Ko Eun-Ji , Cha Hee-Jae
Published: January 2022

Human endogenous retroviruses (HERVs) are ancient, currently inactive, and non-infectious due to recombination, deletions, and mutations in the host genome. However, HERV-derived elements are involved in physiological phenomena including inflammatory response. In recent studies, HERV-derived elements were involved directly in various inflammatory diseases including autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Sjogren’s syndrome. Regarding the involvement of HERV-derived elements in inflammation, two possible mechanisms have been proposed. First, HERV-derived elements cause nonspecific innate immune processes. Second, HERV-derived RNA or proteins might stimulate selective signaling mechanisms. However, it is unknown how silent HERV elements are activated in the inflammatory response and what factors and signaling mechanisms are involved with HERV-derived elements. In this review, we introduce HERV-related autoimmune diseases and propose the possible action mechanisms of HERV-derived elements in the inflammatory response at the molecular level.
La construction sociale de la profession enseignante
Authors: Lelis Isabel
Published: January 2022

Ce texte a comme objectif de mettre en lumière l’identité sociale des enseignants, forgée dans des processus de socialisation familiale, scolaire et professionnelle. Il s’agit de présenter, à partir d’histoires de vie d’institutrices, les significations attribuées à la profession dans des contextes de sélection sociale et scolaire. En s’appuyant sur des contributions de la sociologie, cette recherche a exploré la constitution de l’habitus chez les enseignants et enseignantes, les stratégies développées au sein de trajectoires ayant comme but la conquête de titres scolaires, les entrées informelles dans la profession, ainsi que le poids de la formation initiale et de l’école, en tant que locus de travail, dans la façon dont les enseignants et enseignantes vivent leur travail. En tenant compte du fait que la représentation sociale de l’enseignement, au moment de l’émergence d’une école de masse, a été modifiée, mettant ainsi en évidence des processus de déqualification des enseignants et enseignantes, cette étude remet en question les images de passivité, de négligence et d’incompétence technique qui leur sont attribuées par le pouvoir public et l’université. Elle suggère aussi qu’il est possible de travailler la dimension de la personne de l’enseignant, celle de l’organisation scolaire et celle de la profession comme étant une dimension collective, et ce, par la voie de politiques publiques répondant davantage aux besoins concrets du corps enseignant.
Au-delà des renforcements intrinsèques
Authors: Hargreaves Andy
Published: January 2022

Les enseignants ne travaillent ni pour l’argent, ni pour les vacances. Malgré toutes les contraintes du métier, en définitive, les enseignants oeuvrent pour les enfants. Ce sont les enfants et la vie de la classe qui constituent la récompense primordiale des enseignants; c’est souvent même la seule. Ce fait est soutenu par cette recherche. En effet, l’auteur étudie la relation pédagogique, telle que perçue par les enseignants, et ce que les enseignants du primaire et du secondaire en retirent. Ce sont les émotions associées et produites par l’enseignement, ainsi que leurs effets sur l’enseignement, qui sont au centre de l’étude. Celle-ci s’appuie sur trois enquête réalisées par entrevues auprès d’enseignants ontariens du primaire et du secondaire. L’analyse révèle que les enseignants valorisent beaucoup la relation affective avec leurs élèves et l’attachement ressenti de part et d’autre; ils estiment qu’une compréhension emphatique des élèves est un ingrédient essentiel d’un bon enseignement et que les émotions doivent être reconnues et intégrées. De plus, la dimension affective influence l’enseignement dispensé, sa planification et sa structuration. Enfin, l’étude met en lumière des différences significatives dans la place faite aux émotions entre le primaire et le secondaire.
La conceptualisation de la tâche en didactique des langues secondes : l’enseignement des langues basé sur la tâche et l’approche actionnelle
Authors: Payant Caroline , Michaud Gabriel
Published: January 2022

L’apprentissage d’une nouvelle langue par l’entremise des tâches suscite l’intérêt de plusieurs chercheurs et a été conceptualisé selon deux orientations, à savoir l’enseignement des langues basé sur les tâches (ELBT) (Task-based language teaching) et l’approche actionnelle. Le présent article vise à décrire dans un premier temps ces deux importantes approches pour voir en quoi elles se recoupent ou non et, dans un deuxième temps, à présenter des options didactiques quant à la façon d’élaborer des tâches pédagogiques qui peuvent répondre aux besoins des apprenants.
L’intégration des unités phraséologiques à l’intérieur de l’approche par les tâches : l’expérience du projet Rêver en français
Authors: Bejarano Javier , Duchemin Marie
Published: January 2022

Le but de cet article est de faire part d’une des spécificités du projet Rêver en français, dont l’objectif est le soutien à l’apprentissage du français chez des étudiants internationaux inscrits aux études supérieures. À l’intérieur d’ateliers conçus selon les principes de l’approche basée sur les tâches et mis sur pied afin de répondre aux intérêts et aux besoins déclarés par les étudiants, les connaissances lexicales sont priorisées. Dans le but de construire ces dernières, jugées essentielles à la réalisation des tâches, les apprenants sont invités à s’engager dans des prétâches interactives et dynamiques mettant l’accent sur l’exposition à des mots individuels et à des unités phraséologiques d’utilisation fréquente chez les locuteurs natifs (p. ex. : débarquer de l’autobus, argent comptant). Étant donné les caractéristiques propres aux unités phraséologiques ainsi que les difficultés d’appropriation que ces dernières peuvent causer, trois traitements pédagogiques ont été retenus : 1) la présentation des unités phraséologique en tant qu’entités indivisibles, 2) la mise en évidence de l’input et 3) la fréquence d’exposition. Dans cet article, nous exposons la démarche de conception des prétâches et nous l’illustrons à l’aide d’une sélection de trois prétâches tirées du projet facilitant la réalisation d’une tâche principale.
Nunavut Urban Futures: Vernaculars, Informality and Tactics (Research Note)
Authors: Sheppard Lola
Published: January 2022

The Canadian Arctic, and Nunavut in particular, is one of the fastest-growing regions per capita in the country, raising the question as to what might constitute an emerging Arctic Indigenous urbanism. One of the cultural challenges of urbanizing Canadian North is that for most Indigenous peoples, permanent settlement, and its imposed spatial, temporal, economic, and institutional structures, has been antithetical to traditional ways of life and culture, which are deeply tied to the land and to seasons. For the past seventy-five years, architecture, infrastructure, and settlement form have been imported models serving as spatial tools of cultural colonization that have intentionally erased local culture and ignored geographic specificities. As communities in Nunavut continue to grow at a rapid rate, new planning frameworks are urgently needed. This paper outlines three approaches that could constitute the beginning of more culturally reflexive planning practices for Nunavut: (1) redefining the northern urban vernacular and its role in design; (2) challenging the current top-down masterplan by embracing strategies of informal urbanism; and (3) encouraging planning approaches that embrace territorial strategies and are more responsive to geography, landscape, and seasonality.
Vulnerability and Volition in the Testamentary Law of Undue Influence and Captation
Authors: Campbell Angela
Published: January 2022

This article examines how contemporary analyses of vulnerability theory are reflected in legal approaches to undue influence and captation in the Canadian common law of wills and estates and in the Civil Code of Québec in the law of succession. Critical theorists point to the risks of assuming that vulnerability lies exclusively with the elderly and persons with disabilities. The equation risks oversimplifying matters, which could compromise the equality and dignity of members of these groups. There is also a risk of overlooking the harm that may be suffered by those who are victims of social or economic oppression. A more nuanced approach posits that vulnerability is a common human trait that cuts across social identities and experiences.

Due to prevailing assumptions about vulnerability, this article hypothesizes that challenges to wills based on undue influence and captation will most often occur when the testator is elderly and/or has a disability at the time of execution of the will. Canadian common law and Quebec civil law jurisprudence are examined to assess this hypothesis. This analysis reveals that certain conditions do give rise to triggers heightened judicial scrutiny of wills, but that they do not in and of themselves determine legal outcomes. The case law thus suggests a moderate—but tempered—risk that courts will draw presumptions about age and capacity when assessing the presence of undue influence or captation. Perhaps more significant is the absence of challenges to wills involving young and healthy testators. Jurists might therefore wonder whether we are at risk of overlooking some cases of untoward conduct due to the conceptual associations we make between age, incapacity and vulnerability.
Des enjeux des audiences à distance
Authors: Piquet Hélène
Published: January 2022

Cette étude porte sur les Orientations quant aux audiences en mode semi-virtuel que la Cour du Québec a publiées le 30 novembre 2020, lesquelles s’inscrivent dans un courant mondial de réflexion sur la dématérialisation de la justice. La Cour du Québec a axé son travail sur deux enjeux indissociables. Le premier, analysé à la lumière de l’architecture judiciaire, a pour objet une rectification des représentations que les justiciables se font de la justice dans le contexte des audiences à distance. La Cour du Québec mobilise, à cette fin, la symbolique judiciaire du palais de justice et du juge. Le second enjeu, porteur d’innovation conceptuelle, vise à assurer que l’audience à distance en est une de qualité. Dans ce but, la Cour du Québec a établi des critères qui permettront au juge de choisir le mode d’audience approprié à chaque affaire (MAACA).
La primauté de l’efficacité dans l’administration d’une justice en crise : solutions judiciaires dans une perspective nord-américaine
Authors: Chaffai-Parent Shana , Piché Catherine
Published: January 2022

Crise d’importance mondiale, la pandémie de COVID-19 a entraîné un ralentissement des activités de la société civile, de l’économie et de la justice. Face à l’incertitude générée, les tribunaux ont été ralentis, sinon paralysés, en plus de devoir mettre en place une justice d’urgence par processus hybrides ou spéciaux. Dans un tel contexte, la recherche de mesures d’efficacité devient vitale. Le présent article contribue donc à la réflexion entreprise sur l’efficacité du système judiciaire en temps de pandémie et de post-pandémie. La crise sanitaire semble avoir encouragé une évolution rapide de l’organisation des services judiciaires. Cette évolution fera-t-elle place à une transformation durable et profonde de la justice civile? Le présent article fera état de mesures et de pratiques exemplaires établies au Québec, et ailleurs au Canada et en Amérique du Nord, visant à promouvoir l’efficacité au chapitre de l’administration de la justice et l’adjudication des litiges, et à réduire les délais judiciaires. Précisément, trois catégories de mesures et pratiques seront abordées, soit les mesures de gestion efficace des instances (Partie I), les modes privés de règlement des différends intégrés à l’activité des tribunaux étatiques (Partie II) et les mesures technologiques (Partie III). Nous verrons que chaque système de justice civile recherche le délicat équilibre entre les garanties procédurales fondamentales, la qualité et l’efficacité de la justice. Nous conclurons l’article sur la question des contours d’un système de justice civile efficace et accessible.
Gabrielle Roy, pionnière en paroles et en gestes
Authors: Harvey Carol J.
Published: January 2022

Cet article met en valeur certains aspects de la vie et de l’oeuvre de Gabrielle Roy, la célèbre romancière manitobaine, qui font d’elle une pionnière. Dans sa vie, Roy fait preuve d’une indépendance rare à son époque en refusant le rôle stéréotypé accordé aux femmes de sa génération. Elle part seule en Europe et voyage un peu partout au Canada comme journaliste et reporter. Quant à son oeuvre, elle est reconnue dès Bonheur d’occasion comme originale. De plus, dans bon nombre de ses romans, par les paysages et les personnages qu’elle décrit, Roy est parmi les premiers écrivains à faire connaître le Manitoba français et à inscrire les immigrants de diverses nationalités dans la littérature canadienne. En paroles et en gestes, Roy est digne de figurer parmi ces femmes du Manitoba français qui sont de véritables pionnières.
Monitoring Services to Support Continuous Curriculum Engineering
Authors: Rudzajs Peteris , Kirikova Marite
Published: January 2022

Continuous and rapid developments in science and technology have raised a challenge for compliance between the learning content provided by study programs and (1) the actual state of art in the domains the programs are addressing and (2) the actual needs of companies that will employ the graduates of these programs. To achieve such compliance continuously, the digitalization of learning content (curriculum) engineering could provide supporting tools that facilitate awareness of incompliance, which is the first step in introducing changes in the learning content. In this article we discuss how such awareness, regarding the needs of companies, can be supported by a service system that monitors the gap between educational demand and offer. The proposed service system provides possibilities for automatic, semi-automatic and manual analysis of texts representing the educational demand, versus the texts representing the educational offer. The implementation of the service system has been demonstrated, having been applied at university. The experiments showed that the system can provide valuable information for educational content development, but its maintenance and incorporation in study process management and curriculum engineering still require additional research.
Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells
Authors: La Greca Alejandro , Bellora Nicolás , Le Dily François , Jara Rodrigo , Nacht Ana Silvina , Quilez Oliete Javier , Villanueva José Luis , Vidal Enrique , Merino Gabriela , Fresno Cristóbal , Tarifa Reischle Inti , Vallejo Griselda , Vicent Guillermo , Fernández Elmer , Beato Miguel , Saragüeta Patricia
Published: January 2022

Estrogen (E2) and Progesterone (Pg), via their specific receptors (ERalpha and PR), are major determinants in the development and progression of endometrial carcinomas, However, their precise mechanism of action and the role of other transcription factors involved are not entirely clear. Using Ishikawa endometrial cancer cells, we report that E2 treatment exposes a set of progestin-dependent PR binding sites which include both E2 and progestin target genes. ChIP-seq results from hormone-treated cells revealed a non-random distribution of PAX2 binding in the vicinity of these estrogen-promoted PR sites. Altered expression of hormone regulated genes in PAX2 knockdown cells suggests a role for PAX2 in fine-tuning ERalpha and PR interplay in transcriptional regulation. Analysis of long-range interactions by Hi-C coupled with ATAC-seq data showed that these regions, that we call ‘progestin control regions’ (PgCRs), exhibited an open chromatin state even before hormone exposure and were non-randomly associated with regulated genes. Nearly 20% of genes potentially influenced by PgCRs were found to be altered during progression of endometrial cancer. Our findings suggest that endometrial response to progestins in differentiated endometrial tumor cells results in part from binding of PR together with PAX2 to accessible chromatin regions. What maintains these regions open remains to be studied.
Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells
Authors: Ng Wai Hoe , Johnston Elizabeth K , Tan Jun Jie , Bliley Jacqueline M , Feinberg Adam W , Stolz Donna B , Sun Ming , Wijesekara Piyumi , Hawkins Finn , Kotton Darrell N , Ren Xi
Published: January 2022

The extensive crosstalk between the developing heart and lung is critical to their proper morphogenesis and maturation. However, there remains a lack of models that investigate the critical cardio-pulmonary mutual interaction during human embryogenesis. Here, we reported a novel stepwise strategy for directing the simultaneous induction of both mesoderm-derived cardiac and endoderm-derived lung epithelial lineages within a single differentiation of human-induced pluripotent stem cells (hiPSCs) via temporal specific tuning of WNT and nodal signaling in the absence of exogenous growth factors. Using 3D suspension culture, we established concentric cardio-pulmonary micro-Tissues (μTs), and expedited alveolar maturation in the presence of cardiac accompaniment. Upon withdrawal of WNT agonist, the cardiac and pulmonary components within each dual-lineage μT effectively segregated from each other with concurrent initiation of cardiac contraction. We expect that our multilineage differentiation model will offer an experimentally tractable system for investigating human cardio-pulmonary interaction and tissue boundary formation during embryogenesis.
A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease
Authors: Timmons James A , Anighoro Andrew , Brogan Robert J , Stahl Jack , Wahlestedt Claes , Farquhar David Gordon , Taylor-King Jake , Volmar Claude-Henry , Kraus William E , Phillips Stuart M
Published: January 2022

Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; however, barriers include uncertainty whether in vitro transcriptomic assays yield quantitative pharmacological data, or how to optimise assay design to best reflect in vivo human disease. We developed a clinical-based human tissue IR signature by combining lifestyle-mediated treatment responses (>500 human adipose and muscle biopsies) with biomarkers of disease status (fasting IR from >1200 biopsies). The assay identified a chemically diverse set of >130 positively acting compounds, highly enriched in true positives, that targeted 73 proteins regulating IR pathways. Our multi-gene RNA assay score reflected the quantitative pharmacological properties of a set of epidermal growth factor receptor-related tyrosine kinase inhibitors, providing insight into drug target specificity; an observation supported by deep learning-based genome-wide predicted pharmacology. Several drugs identified are suitable for evaluation in patients, particularly those with either acute or severe chronic IR.
Systematic investigation of the link between enzyme catalysis and cold adaptation
Authors: Stark Catherine , Bautista-Leung Teanna , Siegfried Joanna , Herschlag Daniel
Published: January 2022

Cold temperature is prevalent across the biosphere and slows the rates of chemical reactions. Increased catalysis has been predicted to be a dominant adaptive trait of enzymes to reduced temperature, and this expectation has informed physical models for enzyme catalysis and influenced bioprospecting strategies. To systematically test rate enhancement as an adaptive trait to cold, we paired kinetic constants of 2223 enzyme reactions with their organism’s optimal growth temperature (TGrowth) and analyzed trends of rate constants as a function of TGrowth. These data do not support a general increase in rate enhancement in cold adaptation. In the model enzyme ketosteroid isomerase (KSI), there is prior evidence for temperature adaptation from a change in an active site residue that results in a tradeoff between activity and stability. Nevertheless, we found that little of the rate constant variation for 20 KSI variants was accounted for by TGrowth. In contrast, and consistent with prior expectations, we observed a correlation between stability and TGrowth across 433 proteins. These results suggest that temperature exerts a weaker selection pressure on enzyme rate constants than stability and that evolutionary forces other than temperature are responsible for the majority of enzymatic rate constant variation.
Human-robot interaction: the impact of robotic aesthetics on anticipated human trust
Authors: Pinney Joel , Carroll Fiona , Newbury Paul
Published: January 2022

Background

Human senses have evolved to recognise sensory cues. Beyond our perception, they play an integral role in our emotional processing, learning, and interpretation. They are what help us to sculpt our everyday experiences and can be triggered by aesthetics to form the foundations of our interactions with each other and our surroundings. In terms of Human-Robot Interaction (HRI), robots have the possibility to interact with both people and environments given their senses. They can offer the attributes of human characteristics, which in turn can make the interchange with technology a more appealing and admissible experience. However, for many reasons, people still do not seem to trust and accept robots. Trust is expressed as a person’s ability to accept the potential risks associated with participating alongside an entity such as a robot. Whilst trust is an important factor in building relationships with robots, the presence of uncertainties can add an additional dimension to the decision to trust a robot. In order to begin to understand how to build trust with robots and reverse the negative ideology, this paper examines the influences of aesthetic design techniques on the human ability to trust robots.

Method

This paper explores the potential that robots have unique opportunities to improve their facilities for empathy, emotion, and social awareness beyond their more cognitive functionalities. Through conducting an online questionnaire distributed globally, we explored participants ability and acceptance in trusting the Canbot U03 robot. Participants were presented with a range of visual questions which manipulated the robot’s facial screen and asked whether or not they would trust the robot. A selection of questions aimed at putting participants in situations where they were required to establish whether or not to trust a robot’s responses based solely on the visual appearance. We accomplished this by manipulating different design elements of the robots facial and chest screens, which influenced the human-robot interaction.

Results

We found that certain facial aesthetics seem to be more trustworthy than others, such as a cartoon face versus a human face, and that certain visual variables (i.e., blur) afforded uncertainty more than others. Consequentially, this paper reports that participant’s uncertainties of the visualisations greatly influenced their willingness to accept and trust the robot. The results of introducing certain anthropomorphic characteristics emphasised the participants embrace of the uncanny valley theory, where pushing the degree of human likeness introduced a thin line between participants accepting robots and not. By understanding what manipulation of design elements created the aesthetic effect that triggered the affective processes, this paper further enriches our knowledge of how we might design for certain emotions, feelings, and ultimately more socially acceptable and trusting robotic experiences.
Género y ficción televisiva: ¿Nuevas feminidades y masculinidades en la serie mexicana Club de Cuervos?
Authors:   Universidad de Guadalajara (México), Contreras Tinoco Karla , Alfaro-Beracoechea Laura ,   Universidad de Guadalajara (México)
Published: January 2022

El objetivo de este estudio es analizar las características identitarias, roles, ámbitos de actuación y estereotipos de género en la serie de ficción televisiva mexicana Club de Cuervos (2015), proyectada en un servicio de streaming. De manera independiente, dos jueces realizaron un análisis de su contenido, basado en un modelo representacional temático de la primera temporada. En los resultados destaca que los personajes hombres se presentan como consejeros, exitosos, propositivos, abnegados e hipersexualizados. Asimismo, tienen mayor presencia en el espacio público y establecen más homosocialidad. Las mujeres, en cambio, se presentan como amorosas, tiernas, hipersexualizadas, aparecen más en el espacio privado y tienen más relaciones heterosociales. Se discuten las implicancias de las diferencias entre género en las varias categorías y de las nuevas masculinidades en la representación de los hombres mexicanos. Se concluye que la serie intenta romper con las masculinidades y feminidades hegemónicas en características identitarias, presentando nuevos modelos de masculinidad en distintos personajes. También reproduce roles y figuras de una identidad de género constituida por el ser para otros y subordinada a los hombres.
La representación del suicidio en los medios portugueses entre 2013 y 2017
Authors:   Universidad de Minho, Araújo Rita , Lopes Felisbela ,   Universidad de Minho
Published: January 2022

El suicidio es una de las principales causas de muerte en el mundo desarrollado y está condicionado por varios factores (Gandy & Terrion, 2015). Los medios de comunicación no son una de las variables más sensibles, pero podrían ser un medio eficaz de prevención. Por eso, es importante comprender qué tipo de cobertura periodística se realiza a este nivel . En este artículo, buscamos analizar la prensa diaria portuguesa de cobertura nacional en la segunda década del siglo XXI. Con una muestra de 14.243 textos de salud publicados en diarios, identificamos los contenidos acerca de enfermedades (4651) y analizamos en profundidad los textos que se enfocaban en el suicidio: 74. Llegamos a la conclusión de que los periodistas podrían, a través de su trabajo, ser un freno o una alerta en relación a un comportamiento de riesgo que, en algunos casos, resulta fatal, para evitar, por ejemplo, títulos sensacionalistas o mencionar estructuras de apoyo para los que necesitan ayuda en este nivel. Los periodistas están fracasando en ese aspecto.
Representación fotográfica de las atletas en la prensa deportiva digital española durante los Juegos Olímpicos de Río
Authors:   Universidad de Granada (España), Muñoz-Muñoz Ana M , Salido-Fernández Juana ,   Universidad de Granada (España)
Published: January 2022

Este artículo estudia la representación de las imágenes femenina y masculina en la prensa deportiva digital española durante los Juegos Olímpicos de Río 2016 para desvelar si existe un encuadre visual diferenciado de género. Se analiza el contenido de 3738 noticias a través de ocho variables: género del protagonista, cantidad y tamaño de las fotografías, tipo de deporte, contenido de las imágenes, acción del protagonista, presencia de sesgos o estereotipos de género y sus tipologías. Los hallazgos muestran una infrarrepresentación en la cobertura visual del deporte femenino y su trivialización mediante un encuadre noticioso ambivalente: aunque de forma general no ofrece un contexto diferenciado de género, tiende a representar a las deportistas en mayor medida en disciplinas consideradas apropiadas en función de su sexo y de una forma pasiva. Asimismo, se ha encontrado una cierta presencia de sesgos y estereotipos de género mediante marcos de sexualización y belleza, imágenes degradantes y mayor énfasis en las emociones, en la maternidad y la vida familiar femeninas. Todo ello puede sesgar la percepción de la audiencia, que puede valorar el deporte femenino como menos relevante que el masculino.
Vejez y radio en la pandemia: el caso de la Cadena SER y Radio Nacional de España
Authors:   Universidad de Sevilla (España), Guarinos Virginia , Martín-Pena Daniel ,   Universidad de Extremadura
Published: January 2022

Uno de los temas informativos generados de forma global por la crisis pandémica COVID-19 es el referente al contagio y fallecimiento de la población de más de 65 años. Dicho foco ha sido tratado en España por todos los medios de comunicación. En el marco de los Estudios etarios, esta investigación analiza la presencia y representación de la vejez en la radio española durante el confinamiento y la resignificación de un estereotipo de vejez activa que había sido sustituido en los medios informativos, la ficción y la publicidad en las dos últimas décadas por una imagen de la edad dorada relacionada con el envejecimiento activo. Se estudian las programaciones radiofónicas de la Cadena SER, la emisora privada con la mayor audiencia según el Estudio General de Medios, y de Radio Nacional de España durante cuatro días señalados del confinamiento: el día del inicio del estado de alarma en el país, el comienzo de la fase 0 de desconfinamiento y otros dos días intermedios relacionados con la emergencia en las residencias de mayores. Se analiza un total de 14 programas, 41 ediciones y 118 horas de radio. Los resultados muestran la existencia de contenidos de edadismo positivo, tanto en la representación de la vejez, de nuevo anclada en la dependencia, la fragilidad, la enfermedad y la muerte, como en el nivel de presencia del tema.
Digital Leisure: An Opportunity for Intergenerational Well-Being in Times of Pandemic?
Authors: Alonso Ruiz Rosa Ana , de Jubera Ocón Magdalena Sáenz , Valdemoros San Emeterio María Ángeles , de León Elizondo Ana Ponce
Published: January 2022

Leisure activities shared by grandparents and grandchildren provide important benefits. The health and humanitarian crisis caused by the coronavirus (COVID-19) pandemic has made it necessary to use digital tools to alleviate the lack of contact between adults and children. This paper had as its aim to identify the digital leisure shared by grandparents and their pre-adolescent grandchildren (10–12 years old) before and during the pandemic, as well as its contribution to intergenerational well-being from a holistic paradigm, ultimately aiming to determine whether that digital leisure constitutes an experience of human development for young and old people alike. The sample was made up of 153 grandparents of 10-to-12-year-old children living in the north of Spain. Alongside the use of an ad hoc questionnaire, descriptive and inferential analyses were carried out. Most intergenerational leisure activities ceased to be performed during the lockdown, except for those that could be carried out remotely, thanks to information and communication technologies, which ensured the continuity of social and family interactions. Technological connectivity between generations provided greater support to communication and meaningful relationships, additionally facilitating active aging processes.
Antimutagenic Activity of Cassia Auriculata Linn Fractions along with Anticancer Activity in Male Albino Mice
Authors: Kewatkar Shailesh M. , Bhusari Dipak V , Chakolkar Madhav , Joshi Amit , Jain Shirish P. , Raj Chanchal Navin
Published: January 2022

Background: In recent years, there has been a surge in interest in studying plant-derived materials and their impact on DNA. Herbal products include a number of natural substances that may help protect cells against mutagen-induced cell damage.

Aim: The purpose of this research was to assess the genotoxic effects of Cassia Auriculata Linn flavonoids (CAF) and Cassia Auriculata Linn saponin (CAS) rich fractions on mouse bone marrow cells utilizing chromosomal aberration test and micronucleus assay.

Methodology: The suppressive impact of CAF and CAS on 7, 12-dimethylbenz (α) anthracene (DMBA) and Croton oil induced skin tumor promotion in mice with topical administration twice weekly for 18 weeks is also investigated in this work. Three dosages of 100 and 200 mg/kg body weight were used. Single oral dosages of CAF and CAS Fraction at the three levels did not enhance the number of micronucleate polychromatic erythrocytes in the micronucleus experiment.

Result: In mice bone marrow cells, a single oral treatment of CAF and CAS fraction revealed no significant alterations in mitotic indices or chromosomal aberration induction. The clastogenicity of CYP was considerably decreased by pretreatment with CAF and CAS fraction. As a result, it can be stated that CAF and CAS fraction had no genotoxic impact on mouse bone marrow cells.

Conclusions: The portions of Cassia Auriculata have been shown to be non-genotoxic and non-clastogenic at the quantities utilized in this investigation. CAF and CAS Fraction might possibly be a promising skin tumor promotion reducing agent, according to this research.
Milk Fortification with Vitamin A & D: A Need of the Hour in India
Authors: Babu B. Kishore , Sai T. Pavan
Published: January 2022

Micronutrient deficiency is caused by a diet deficient in important vitamins and minerals, and it continues to be a serious public health issue for many low- and middle-income countries' populations. Vitamin A and D deficiency is extremely common in India, affecting both young children and adults. With 146.3 million tonnes of milk produced annually, India is the world's largest producer, yet only around 9% of the milk is fortified with vitamins and minerals.

Milk fortification is one of the treatments for vitamin deficiency. Milk is one of the most nutrient-dense foods available. In India, it is a staple dish that is consumed by people of all age groups. Regular consumption of fortified milk led to an 18% reduction in diarrhoea, a 26% reduction in pneumonia, 7% fewer days with a high fever, and 15% fewer days sick with severe sickness. Out of 416 LLPD produced, about 198.4 LLPD gets fortified currently in India, reaching about 121 million people.  There is still a significant gap between production and fortification. Governments must take appropriate steps to improve milk fortification and make India a healthy country.
Orchestrated Yolk–Shell Nanohybrids Regulate Macrophage Polarization and Dendritic Cell Maturation for Oncotherapy with Augmented Antitumor Immunity
Authors: Zhao Xiaoyi , Guo Kangli , Zhang Kai , Duan Shun , Chen Meiwan , Zhao Nana , Xu Fu‐Jian
Published: January 2022

The protumoral and immunosuppressive tumor microenvironments greatly limit the antitumor immune responses of nanoparticles for cancer immunotherapy. Here, the intrinsic immunomodulatory effects of orchestrated nanoparticles and their ability to simultaneously trigger tumor antigen release, thereby reversing immunosuppression and achieving potent antitumor immunity and augmented cancer therapy, are explored. By optimizing both the composition and morphology, a facile strategy is proposed to construct yolk–shell nanohybrids (Fe3O4@C/MnO2‐PGEA, FCMP). The intrinsic immunomodulatory effects of FCMP are utilized to reprogram macrophages to M1 phenotype and induce the maturation of dendritic cells. In addition, the chemical, magnetic, and optical properties of FCMP contribute to amplified immunogenic cell death induced by multiaugmented chemodynamic therapy (CDT) and synergistic tumor treatment. Taking advantage of the unique yolk–shell structure, accurate T1‐T2 dual‐mode magnetic resonance imaging can be realized and CDT can be maximized through sufficient exposure of both the Fe3O4 core and MnO2 shell. Potent antitumor effects are found to substantially inhibit the growth of both primary and distant tumors. Furthermore, the strategy can be extended to the synthesis of other yolk–shell nanohybrids with tailored properties. This work establishes a novel strategy for the fabrication of multifunctional nanoplatforms with yolk‐shell structure for effective cancer therapy with immunomodulation‐enhanced antitumor immunity.
Fundamental Loading‐Curve Characteristics of the Persistent Phosphor SrAl2O4:Eu2+,Dy3+,B3+: The Effect of Temperature and Excitation Density
Authors: Delgado Teresa , Gartmann Nando , Walfort Bernhard , LaMattina Fabio , Pollnau Markus , Rosspeintner Arnulf , Afshani Jafar , Olchowka Jacob , Hagemann Hans
Published: January 2022

The compound SrAl2O4:Eu2+,Dy3+ is currently one of the best‐performing persistent phosphors and numerous studies have been performed to understand the mechanisms involved in its afterglow process. One aspect which so far has received only limited attention is the dependence of loading curve characteristics on dopant concentrations. Herein, a detailed study of the loading curves of SrAl2O4:Eu2+,Dy3+ as a function of composition, sample temperature, and pump intensity is presented, completed by emission decay and quantum yield measurements. The observed emission decays can be described using the Inokuti−Hirayama equation for a Dexter energy transfer (ET) process. As the Dexter ET rate and the electron transfer rate have a similar radial dependence, the Inokuti−Hirayama equation can also describe the electron transfer process involved for the trapping process. These observations indicate that in this persistent phosphor, the trapping process is a local process; however, different types of traps appear to present different “Dexter” critical radii R0. This electron transfer is also temperature dependent, which requires further investigations.
Synergistic Catalysis of Co‐Zr/CNx Bimetallic Nanoparticles Enables Reductive Amination of Biobased Levulinic Acid
Authors: Wu Pei‐dong , Li Hu , Fang Zhen
Published: January 2022

Bimetallic synergy and carbon–nitrogen doping can contribute to enhanced catalytic activity due to the strong electronic state and unique geometrical structure. In this work, a series of biomass‐derived Co‐M bimetallic CN doped catalysts (Co‐M@Chitosan‐X; M = Zr, Ni, Fe, Cu, In; X denotes the molar percentage of M) are prepared via simple oil bath reflow and annealing. The Co‐Zr@Chitosan‐X catalysts are determined to contain alloys (Co‐Zr), metal‐carbon bonds (Co‐C, Zr‐C), metal‐nitrogen bonds (Co‐N, Zr‐N), and metal oxides (Co3O4, ZrO2) through a series of characterizations, in which graphite‐coated alloys and metal oxides are found to be the catalytically active species. The doping of the second metal results in a significant enhancement for the number of active sites in the catalyst, and the d‐band center is shifted toward a deviation from the Fermi energy level. Among the tested catalysts, Co‐Zr@Chitosan‐20 exhibits superior catalytic activity for the reductive amination of biobased levulinic acid to 5‐methyl‐2‐pyrrolidone in 99.3% selectivity and 92.8% yield. This non‐noble metal bimetallic synergistic catalytic protocol opens an avenue for efficiently producing biomass‐derived nitrogenous chemicals.
Cyanine‐Doped Lanthanide Metal–Organic Frameworks for Near‐Infrared II Bioimaging
Authors: Liang Tao , Guo Zhi , He Yifan , Wang Yanying , Li Chunya , Li Zhen , Liu Zhihong
Published: January 2022

Developing metal–organic frameworks (MOFs) with strong near‐infrared II (NIR‐II, 1000–1700 nm) emission is significant for biomedical research but highly challenging. So far there are no MOFs reported for NIR‐II imaging in vivo due to their poor NIR‐II emission efficiency. Herein, a strategy is proposed to prepare MOFs with strong NIR‐II emission, by integrating NIR dye IR‐3C and Ln3+ (Ln = Yb, Nd, and Er) into a same framework. IR‐3C with high photon‐absorption ability harvests the excitation photons and transfers energy to Ln3+ via a resonance energy transfer pathway, significantly enhancing the NIR‐II emission of Ln3+. The as‐obtained Er‐BTC‐IR exhibits excellent NIR‐IIb (1500–1700 nm) emission efficiency in aqueous phase and good biocompatibility after surface modification, which provides advanced bioimaging performance in vivo. It is able to clearly delineate the vessels, spine, and lymph of mice, and also to differentiate the vessels with acute vascular inflammation. This strategy paves the way to the preparation of NIR‐II emissive MOFs and will promote their bioapplication.
Spherical Ni3S2/Fe‐NiPx Magic Cube with Ultrahigh Water/Seawater Oxidation Efficiency
Authors: Luo Xu , Ji Pengxia , Wang Pengyan , Tan Xin , Chen Lei , Mu Shichun
Published: January 2022

The rational construction of earth‐abundant and advanced electrocatalysts for oxygen evolution reaction (OER) is extremely desired and significant to seawater electrolysis. Herein, by directly etching Ni3S2 nanosheets through potassium ferricyanide, a novel self‐sacrificing template strategy is proposed to realize the in situ growth of NiFe‐based Prussian blue analogs (NiFe PBA) on Ni3S2 in an interfacial redox reaction. The well‐designed Ni3S2@NiFe PBA composite as precursor displays a unique spherical magic cube architecture composed of nanocubes, which even maintains after a phosphating treatment to obtain the derived Ni3S2/Fe‐NiPx on nickel foam. Specifically, in alkaline seawater, the Ni3S2/Fe‐NiPx as OER precatalyst marvelously realizes the ultralow overpotentials of 336 and 351 mV at large current densities of 500 and 1000 mA cm–2, respectively, with remarkable durability for over 225 h, outperforming most reported advanced OER electrocatalysts. Experimentally, a series of characterization results confirm the reconstruction behavior in the Ni3S2/Fe‐NiPx surface, leading to the in situ formation of Ni(OH)2/Ni(Fe)OOH with abundant oxygen vacancies and grain boundaries, which constructs the Ni3S2/Fe‐NiPx reconstruction system responsible for the remarkable OER catalytic activity. Theoretical calculation results further verify the enhanced OER activity for Ni3S2/Fe‐NiPx reconstruction system, and unveil that the Fe‐Ni2P/FeOOH as active origin contributes to the central OER activity.
Influence of Nanoscale Charge Trapping Layer on the Memory and Synaptic Characteristics of a Novel Rubidium Lead Chloride Quantum Dot Based Memristor
Authors: Das Ujjal , Sarkar Pranab Kumar , Das Dip , Paul Bappi , Roy Asim
Published: January 2022

Memristors are one of the fastest developing electronic devices in the field of data storage and brain inspired neural computing. As a two terminal device, memristors are numerously utilized as resistive random access memories (RRAM) and energy efficient artificial synapses. Herein, the fabrication of perovskite‐type rubidium lead chloride quantum dots (RPCQDs) is reported as a functional layer in a memristive system. The device, Al/RPCQDs/indium doped tin oxide (ITO), exhibits a cycling‐induced decrease in SET voltage, where Al and ITO work as a top and bottom electrode respectively. However, time dependent self‐recovery to the pristine state is observed in the Al/RPCQDs/ITO device. In contrast, the self‐rejuvenation is suppressed when a buffer capped conducting polymer (BCCP) is incorporated on the ITO layer to make a Al/RPCQDs/BCCP/ITO structure. This customized device structure successfully retains the reproducible bipolar switching behavior without severe deviation in operating voltages, which helps in studying reliable memristive properties. In addition, the Al/RPCQDs/BCCP/ITO memristive device also demonstrates some essential synaptic functions such as pair‐pulse facilitation, long‐term potentiation, and long‐term depression.
Calix[4]pyrrolatostannat(II): Ein Tetraamidozinn(II)dianion als starker, metallzentrierter σ‐Donor
Authors: Ruppert Heiko , Greb Lutz
Published: January 2022

Anionische, metallzentrierte Nukleophile sind Verbindungen mit einzigartigen Reaktivitäten. In dieser Arbeit beschreiben wir die Isolierung und vollständige Charakterisierung des ersten Tetraamidozinn(II)dianions, sein Verhalten als Ligand gegenüber Übergangsmetallen und seine Reaktivität als zinnzentriertes Nukleophil. Experimentelle Werte wie der elektronische Tolman Parameter (TEP) und quantenchemische Berechnungen bescheinigen dem Zinn eine σ‐Donorfähigkeit, welche die von Carbenen oder elektronenreichen Phosphinen übertrifft. Gegenüber Übergangsmetallen kann das Stannat(II) als η1‐ oder η5‐Ligand wirken. Mit Aldehyden reagiert es unter Hydridsubstitution zu wertvollen Acylstannaten(IV). Die reduktive Dehalogenierung von Iodbenzol weist auf zugängliche Redoxwege hin, welche durch die Wechselwirkung mit Halogenbindungen vermittelt werden. Calix[4]pyrrolatostannat(II) [2]2 ist das erste Beispiel niedervalenter p‐Block‐Elementkomplexe der Calix[4]pyrrole.
Superlattice in a Ru Superstructure for Enhancing Hydrogen Evolution
Authors: Zhang Juntao , Mao Xinnan , Wang Suling , Liang Lingling , Cao Maofeng , Wang Lu , Li Gen , Xu Yong , Huang Xiaoqing
Published: January 2022

Superlattices are attracting extensive attention due to their unique properties. Nevertheless, the observations of superlattices are limited to those layered structures with weak interlayered interactions, and the effect of the superlattice in metal‐based nanostructures on catalysis is unexplored yet. We here report a facile wet‐chemical method for synthesizing two‐dimensional Ru multilayered nanosheets (Ru MNSs) with a superlattice. Characterizations reveal that the superlattice is formed by stacking Ru layers with twisted angles from 2° to 30°. Owing to the strong synergy between the adjacent layers, Ru MNSs can serve as an efficient catalyst for the alkaline hydrogen evolution reaction (HER). Theoretical calculations reveal that the superlattice can induce the strain effect, which leads to lattice contraction and weak *H adsorption ability, as a result of improved HER performance. This work sheds new light on the utilization of the superlattice on enhancing catalysis in metal‐based materials.
Self‐Adjusting Metal–Organic Framework for Efficient Capture of Trace Xenon and Krypton
Authors: Niu Zheng , Fan Ziwen , Pham Tony , Verma Gaurav , Forrest Katherine A. , Space Brian , Thallapally Praveen K. , Al‐Enizi Abdullah M. , Ma Shengqian
Published: January 2022

The capture of the xenon and krypton from nuclear reprocessing off‐gas is essential to the treatment of radioactive waste. Although various porous materials have been employed to capture Xe and Kr, the development of high‐performance adsorbents capable of trapping Xe/Kr at very low partial pressure as in the nuclear reprocessing off‐gas conditions remains challenging. Herein, we report a self‐adjusting metal‐organic framework based on multiple weak binding interactions to capture trace Xe and Kr from the nuclear reprocessing off‐gas. The self‐adjusting behavior of ATC‐Cu and its mechanism have been visualized by the in‐situ single‐crystal X‐ray diffraction studies and theoretical calculations. The self‐adjusting behavior endows ATC‐Cu unprecedented uptake capacities of 2.65 and 0.52 mmol g−1 for Xe and Kr respectively at 0.1 bar and 298 K, as well as the record Xe capture capability from the nuclear reprocessing off‐gas. Our work not only provides a benchmark Xe adsorbent but proposes a new route to construct smart materials for efficient separations.