bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from In Situ Vaccination with CD204 Gene-Silenced Dendritic Cell, not Unmodified Dendritic Cell, Enhances Radiation Therapy of Prostate Cancer
Authors: Guo Chunqing , Yi Huanfa , Yu Xiaofei , Zuo Daming , Qian Jie , Yang Gary , Foster Barbara A. , Subjeck John R. , Sun Xiaolei , Mikkelsen Ross B. , Fisher Paul B. , Wang Xiang-Yang
Published: April 2023

PDF file, 1232K, SRA/CD204-targeted radio-immunotherapy enhances cytolytic activity of effector T cells.
Supplementary Figures 1-6 from Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo
Authors: Dasmahapatra Girija , Lembersky Dmitry , Son Minkyeong P. , Patel Hiral , Peterson Derick , Attkisson Elisa , Fisher Richard I. , Friedberg Jonathan W. , Dent Paul , Grant Steven
Published: April 2023

PDF file - 402K, SFigure 1: Chemical structures of carfilzomib and obatoclax; SFigure 2: Co-treatment with carfilzomib and obatoclax synergistically induces cell death in SUDHL4 cells by Median Dose Effect analysis; SFigure 3: Combined treatment with carfilzomib and obatoclax fails to induce further NF- �B inactivation compared to single agent treatment in SUDHL4 and OCI-LY10 cells; SFigure 4: Co-exposure of SUDHL16 cells to carfilzomib and obatoclax diminishes the association between Mcl-1 and both Bak and Bim while triggering Bak and Bax activation; SFigure 5: Effects of combined treatment with carfilzomib and obatoclax on weight loss and WBC counts in an SUDHL4 xenograft model; SFigure 6: A schematic diagram depicting potential mechanisms underlying synergistic interaction between carfilzomib and obatoclax in DLBCL cells
Supplementary Figure 2 from Caspase-3–Dependent Mitotic Checkpoint Inactivation by the Small-Molecule Inducers of Mitotic Slippage SU6656 and Geraldol
Authors: Riffell Jenna L. , Jänicke Reiner U. , Roberge Michel
Published: April 2023

Supplementary Figure 2 from Caspase-3–Dependent Mitotic Checkpoint Inactivation by the Small-Molecule Inducers of Mitotic Slippage SU6656 and Geraldol
Supplementary Figure Legends 1-3 from Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin
Authors: Neher Tracy M. , Bodenmiller Diane , Fitch Richard W. , Jalal Shadia I. , Turchi John J.
Published: April 2023

PDF file - 39K
Supplementary Figure 1 from Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin
Authors: Neher Tracy M. , Bodenmiller Diane , Fitch Richard W. , Jalal Shadia I. , Turchi John J.
Published: April 2023

PDF file - 166K
Supplementary Figures 1-3 from The Novel Oral Hsp90 Inhibitor NVP-HSP990 Exhibits Potent and Broad-spectrum Antitumor Activities In Vitro and In Vivo
Authors: Menezes Daniel L. , Taverna Pietro , Jensen Michael R. , Abrams Tinya , Stuart Darrin , Yu Guoying Karen , Duhl David , Machajewski Timothy , Sellers William R. , Pryer Nancy K. , Gao Zhenhai
Published: April 2023

PDF file - 212K
Supplementary Figure 1 from Glutathione-Conjugate Transport by RLIP76 Is Required for Clathrin-Dependent Endocytosis and Chemical Carcinogenesis
Authors: Singhal Sharad S. , Wickramarachchi Dilki , Yadav Sushma , Singhal Jyotsana , Leake Kathryn , Vatsyayan Rit , Chaudhary Pankaj , Lelsani Poorna , Suzuki Sumihiro , Yang Shaohua , Awasthi Yogesh C. , Awasthi Sanjay
Published: April 2023

Supplementary Figure 1 from Glutathione-Conjugate Transport by RLIP76 Is Required for Clathrin-Dependent Endocytosis and Chemical Carcinogenesis
Supplementary Figure 5 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Authors: Li Jing , Cao Bo , Liu Xichun , Fu Xueqi , Xiong Zhenggang , Chen Li , Sartor Oliver , Dong Yan , Zhang Haitao
Published: April 2023

Supplementary Figure 5 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Supplementary Figure 5 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Authors: Santer Frédéric R. , Höschele Philipp P.S. , Oh Su Jung , Erb Holger H.H. , Bouchal Jan , Cavarretta Ilaria T. , Parson Walther , Meyers David J. , Cole Philip A. , Culig Zoran
Published: April 2023

Supplementary Figure 5 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Supplementary Figure 4 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Authors: Santer Frédéric R. , Höschele Philipp P.S. , Oh Su Jung , Erb Holger H.H. , Bouchal Jan , Cavarretta Ilaria T. , Parson Walther , Meyers David J. , Cole Philip A. , Culig Zoran
Published: April 2023

Supplementary Figure 4 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Supplementary Figure 1 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Authors: Li Jing , Cao Bo , Liu Xichun , Fu Xueqi , Xiong Zhenggang , Chen Li , Sartor Oliver , Dong Yan , Zhang Haitao
Published: April 2023

Supplementary Figure 1 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Supplementary Materials, Figures 1-7, Tables 1-2 from High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker α-Methylacyl Coenzyme A Racemase (AMACR/P504S)
Authors: Wilson Brice A.P. , Wang Haofan , Nacev Benjamin A. , Mease Ronnie C. , Liu Jun O. , Pomper Martin G. , Isaacs William B.
Published: April 2023

Supplementary Materials, Figures 1-7, Tables 1-2 from High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker α-Methylacyl Coenzyme A Racemase (AMACR/P504S)
Supplementary Table 1 from Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth
Authors: Bansal Ruchi , Tomar Tushar , Östman Arne , Poelstra Klaas , Prakash Jai
Published: April 2023

PDF file, 61K, Blood parameters of B16 tumor-bearing mice.
Supplementary Table 3 from Expression Signatures of the Lipid-Based Akt Inhibitors Phosphatidylinositol Ether Lipid Analogues in NSCLC Cells
Authors: Zhang Chunyu , Elkahloun Abdel G. , Liao Hongling , Delaney Shannon , Saber Barbara , Morrow Betsy , Prendergast George C. , Hollander M. Christine , Gills Joell J. , Dennis Phillip A.
Published: April 2023

Supplementary Table 3 from Expression Signatures of the Lipid-Based Akt Inhibitors Phosphatidylinositol Ether Lipid Analogues in NSCLC Cells
Supplementary Figure 5 from The NEDD8-Activating Enzyme Inhibitor, MLN4924, Cooperates with TRAIL to Augment Apoptosis through Facilitating c-FLIP Degradation in Head and Neck Cancer Cells
Authors: Zhao Liqun , Yue Ping , Lonial Sagar , Khuri Fadlo R. , Sun Shi-Yong
Published: April 2023

PDF file - 163K
Supplementary Figure Legends 1-3 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Authors: Scaltriti Maurizio , Serra Violeta , Normant Emmanuel , Guzman Marta , Rodriguez Olga , Lim Alice R. , Slocum Kelly L. , West Kip A. , Rodriguez Varenka , Prudkin Ludmila , Jimenez José , Aura Claudia , Baselga José
Published: April 2023

Supplementary Figure Legends 1-3 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Supplementary Figure 1 from The Bcl-2/Bcl-XL/Bcl-w Inhibitor, Navitoclax, Enhances the Activity of Chemotherapeutic Agents In Vitro and In Vivo
Authors: Chen Jun , Jin Sha , Abraham Vivek , Huang Xiaoli , Liu Bernard , Mitten Michael J. , Nimmer Paul , Lin Xiaoyu , Smith Morey , Shen Yu , Shoemaker Alexander R. , Tahir Stephen K. , Zhang Haichao , Ackler Scott L. , Rosenberg Saul H. , Maecker Heather , Sampath Deepak , Leverson Joel D. , Tse Chris , Elmore Steven W.
Published: April 2023

PDF file - 78K
Supplementary Movie from Time-Course Imaging of Therapeutic Functional Tumor Vascular Normalization by Antiangiogenic Agents
Authors: Zhang Qingbei , Bindokas Vytas , Shen Jikun , Fan Hanli , Hoffman Robert M. , Xing H. Rosie
Published: April 2023

Supplementary Movie from Time-Course Imaging of Therapeutic Functional Tumor Vascular Normalization by Antiangiogenic Agents
Supplementary Methods, Figures 1-3, Movie Legend from Time-Course Imaging of Therapeutic Functional Tumor Vascular Normalization by Antiangiogenic Agents
Authors: Zhang Qingbei , Bindokas Vytas , Shen Jikun , Fan Hanli , Hoffman Robert M. , Xing H. Rosie
Published: April 2023

Supplementary Methods, Figures 1-3, Movie Legend from Time-Course Imaging of Therapeutic Functional Tumor Vascular Normalization by Antiangiogenic Agents
Supplementary Figure Legends 1-7 from Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells
Authors: Natoni Alessandro , Murillo Laura S. , Kliszczak Anna E. , Catherwood Mark A. , Montagnoli Alessia , Samali Afshin , O'Dwyer Michael , Santocanale Corrado
Published: April 2023

PDF file - 77K
Supplementary Methods, Figures 1-5 from Reduced Expression of the Androgen Receptor by Third Generation of Antisense Shows Antitumor Activity in Models of Prostate Cancer
Authors: Zhang Yixian , Castaneda Stephen , Dumble Melissa , Wang Maoliang , Mileski Mary , Qu Zhengxing , Kim Steven , Shi Victoria , Kraft Patricia , Gao Ying , Pak Jenny , Sapra Puja , Bandaru Raj , Zhao Hong , Vessella Robert L. , Horak Ivan D. , Greenberger Lee M.
Published: April 2023

PDF file - 304K
Supplementary Figure 3 from Antitumor Activity of Saracatinib (AZD0530), a c-Src/Abl Kinase Inhibitor, Alone or in Combination with Chemotherapeutic Agents in Gastric Cancer
Authors: Nam Hyun-Jin , Im Seock-Ah , Oh Do-Youn , Elvin Paul , Kim Hwang-Phill , Yoon Young-Kwang , Min Ahrum , Song Sang-Hyun , Han Sae-Won , Kim Tae-You , Bang Yung-Jue
Published: April 2023

PDF file - 173K, Induction of Bim by saracatinib treatment
Supplementary Figure 2 from Antitumor Activity of Saracatinib (AZD0530), a c-Src/Abl Kinase Inhibitor, Alone or in Combination with Chemotherapeutic Agents in Gastric Cancer
Authors: Nam Hyun-Jin , Im Seock-Ah , Oh Do-Youn , Elvin Paul , Kim Hwang-Phill , Yoon Young-Kwang , Min Ahrum , Song Sang-Hyun , Han Sae-Won , Kim Tae-You , Bang Yung-Jue
Published: April 2023

PDF file - 215K, mRNA and protein expression level of integrin �8 in gastric cancer cell lines
Supplementary Table 1 from Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib
Authors: Giles Keith M. , Kalinowski Felicity C. , Candy Patrick A. , Epis Michael R. , Zhang Priscilla M. , Redfern Andrew D. , Stuart Lisa M. , Goodall Gregory J. , Leedman Peter J.
Published: April 2023

PDF - 197KB, Supplementary Table S1. List of genes upregulated in HN5-ER cells relative to HN5 cells.
Supplementary Figure 4 from Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity In Vivo
Authors: Budhraja Amit , Gao Ning , Zhang Zhuo , Son Young-Ok , Cheng Senping , Wang Xin , Ding Songze , Hitron Andrew , Chen Gang , Luo Jia , Shi Xianglin
Published: April 2023

PDF file - 1.9MB
Supplementary Figure 3 from GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L–Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells
Authors: Schwartz-Roberts Jessica L. , Shajahan Ayesha N. , Cook Katherine L. , Wärri Anni , Abu-Asab Mones , Clarke Robert
Published: April 2023

Supplementary Figure 3 PDF file - 89K, Caspase inhibition fails to abrogate GX-mediated apoptosis
Supplementary Figure 1 from GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L–Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells
Authors: Schwartz-Roberts Jessica L. , Shajahan Ayesha N. , Cook Katherine L. , Wärri Anni , Abu-Asab Mones , Clarke Robert
Published: April 2023

Supplementary Figure 1 PDF file - 3511K, BCL2 is elevated in antiestrogen-resistant breast cancer
Supplementary Table 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Authors: Hasenstein Jason R. , Shin Ho-Chul , Kasmerchak Kelsey , Buehler Darya , Kwon Glen S. , Kozak Kevin R.
Published: April 2023

PDF file, 109K, Toxicity of paclitaxel-containing micelles and Triolimus.
Supplementary Figure 2 from Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
Authors: Ueno Koji , Hirata Hiroshi , Majid Shahana , Yamamura Soichiro , Shahryari Varahram , Tabatabai Z. Laura , Hinoda Yuji , Dahiya Rajvir
Published: April 2023

PDF file - 2.9MB
Supplementary Figure 3 from Inhibition of p38 MAPK-Dependent Excision Repair Cross-Complementing 1 Expression Decreases the DNA Repair Capacity to Sensitize Lung Cancer Cells to Etoposide
Authors: Tsai Min-Shao , Weng Shao-Hsing , Chen Huang-Jen , Chiu Yu-Fan , Huang Yu-Ching , Tseng Sheng-Chieh , Kuo Ya-Hsun , Lin Yun-Wei
Published: April 2023

PDF file - 402K
Supplementary Figure 1 from Inhibition of p38 MAPK-Dependent Excision Repair Cross-Complementing 1 Expression Decreases the DNA Repair Capacity to Sensitize Lung Cancer Cells to Etoposide
Authors: Tsai Min-Shao , Weng Shao-Hsing , Chen Huang-Jen , Chiu Yu-Fan , Huang Yu-Ching , Tseng Sheng-Chieh , Kuo Ya-Hsun , Lin Yun-Wei
Published: April 2023

PDF file - 765K
Supplementary Information from An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735
Authors: Hook Kenneth E. , Garza Scott J. , Lira Maruja E. , Ching Keith A. , Lee Nathan V. , Cao Joan , Yuan Jing , Ye Jingjing , Ozeck Mark , Shi Stephanie T. , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G. , Pavlicek Adam
Published: April 2023

PDF file - 312K, DLDA gene expression classifier.
Supplementary Table and Supplementary Figures 1 through 8 from Inhibition of Wee1 Sensitizes Cancer Cells to Antimetabolite Chemotherapeutics In Vitro and In Vivo, Independent of p53 Functionality
Authors: Van Linden Annemie A. , Baturin Dmitry , Ford James B. , Fosmire Susan P. , Gardner Lori , Korch Christopher , Reigan Philip , Porter Christopher C.
Published: April 2023

PDF - 1164KB, Supplemental Table 1: Inhibition of Wee1 inhibits proliferation of AML cells independent of known molecular abnormalities. Supplemental Figure 1: AML cells are sensitive to MK1775 independent of p53 functionality. Supplemental Figure 2: MK1775 sensitizes AML cells to cytarabine independent of p53 function. Supplemental Figure 3: MK1775 sensitizes AML cells to cytarabine independent of p53 function. Supplemental Figure 4: MK1775 inhibits phosphorylation of CDK1, but does not cause widespread unscheduled mitosis. Supplemental Figure 5: Treatment with MK1775 does not sensitize AML cells to doxorubicin. Supplemental Figure 6: Treatment of AML cells with cytarabine and MK1775 is synergistic independent of p53 function in an isogenic model. Supplemental Figure 7: Treatment of lung cancer cells with antimetabolites and MK1775 is synergistic. Supplemental Figure 8: MK1775 and cytarabine is more effective than cytarabine alone in vivo.
Supplementary Video 4 from Low-Dose Metronomic Oral Dosing of a Prodrug of Gemcitabine (LY2334737) Causes Antitumor Effects in the Absence of Inhibition of Systemic Vasculogenesis
Authors: Francia Giulio , Shaked Yuval , Hashimoto Kae , Sun John , Yin Melissa , Cesta Carolyn , Xu Ping , Man Shan , Hackl Christina , Stewart Julie , Uhlik Mark , Dantzig Anne H. , Foster F. Stuart , Kerbel Robert S.
Published: April 2023

AVI file - 5.9MB
Supplementary Figure 4 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Authors: Bhola Neil E. , Freilino Maria L. , Joyce Sonali C. , Sen Malabika , Thomas Sufi M. , Sahu Anirban , Cassell Andre , Chen Ching-Shih , Grandis Jennifer R.
Published: April 2023

PDF file, 106KB, AR-12 decreases cyclin D1 expression.
Supplementary Figure 1 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Authors: Bhola Neil E. , Freilino Maria L. , Joyce Sonali C. , Sen Malabika , Thomas Sufi M. , Sahu Anirban , Cassell Andre , Chen Ching-Shih , Grandis Jennifer R.
Published: April 2023

PDF file, 38KB, PDK1 siRNA prevents BK-induced growth in UMSCC-1 cells.
Supplementary Figure Legends 1-2 from Low-Dose Metronomic Oral Dosing of a Prodrug of Gemcitabine (LY2334737) Causes Antitumor Effects in the Absence of Inhibition of Systemic Vasculogenesis
Authors: Francia Giulio , Shaked Yuval , Hashimoto Kae , Sun John , Yin Melissa , Cesta Carolyn , Xu Ping , Man Shan , Hackl Christina , Stewart Julie , Uhlik Mark , Dantzig Anne H. , Foster F. Stuart , Kerbel Robert S.
Published: April 2023

PDF file - 64K
Supplementary Figure 1 from Low-Dose Metronomic Oral Dosing of a Prodrug of Gemcitabine (LY2334737) Causes Antitumor Effects in the Absence of Inhibition of Systemic Vasculogenesis
Authors: Francia Giulio , Shaked Yuval , Hashimoto Kae , Sun John , Yin Melissa , Cesta Carolyn , Xu Ping , Man Shan , Hackl Christina , Stewart Julie , Uhlik Mark , Dantzig Anne H. , Foster F. Stuart , Kerbel Robert S.
Published: April 2023

PDF file - 100K
Supplementary Figure Legend from EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics
Authors: Arcila Maria E. , Nafa Khedoudja , Chaft Jamie E. , Rekhtman Natasha , Lau Christopher , Reva Boris A. , Zakowski Maureen F. , Kris Mark G. , Ladanyi Marc
Published: April 2023

PDF file - 64K
Supplementary Table 3 from YM155 Reverses Cisplatin Resistance in Head and Neck Cancer by Decreasing Cytoplasmic Survivin Levels
Authors: Kumar Bhavna , Yadav Arti , Lang James C. , Cipolla Michael J. , Schmitt Alessandra C. , Arradaza Nicole , Teknos Theodoros N. , Kumar Pawan
Published: April 2023

PDF file, 1581KB, HNSCC cell line characteristics.
Supplementary Methods and Figure Legend from A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells
Authors: Lim Yi Chieh , Roberts Tara L. , Day Bryan W. , Harding Angus , Kozlov Sergei , Kijas Amanda W. , Ensbey Kathleen S. , Walker David G. , Lavin Martin F.
Published: April 2023

PDF file, 139K.
Supplementary Figure 5 from A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells
Authors: Lim Yi Chieh , Roberts Tara L. , Day Bryan W. , Harding Angus , Kozlov Sergei , Kijas Amanda W. , Ensbey Kathleen S. , Walker David G. , Lavin Martin F.
Published: April 2023

PDF file, 340K, Rad51 foci formation to measure homologous recombination repair in glioma initiaitng cells.
Supplementary Figure 4 from A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells
Authors: Lim Yi Chieh , Roberts Tara L. , Day Bryan W. , Harding Angus , Kozlov Sergei , Kijas Amanda W. , Ensbey Kathleen S. , Walker David G. , Lavin Martin F.
Published: April 2023

PDF file, 159K, Long-term growth of neurosphere cultures following IR treatment.
Supplementary Methods from Peptidomimetic Src/Pretubulin Inhibitor KX-01 Alone and in Combination with Paclitaxel Suppresses Growth, Metastasis in Human ER/PR/HER2-Negative Tumor Xenografts
Authors: Anbalagan Muralidharan , Ali Alaa , Jones Ryan K. , Marsden Carolyn G. , Sheng Mei , Carrier Latonya , Bu Yahao , Hangauer David , Rowan Brian G.
Published: April 2023

PDF file, 55K.
Supplementary Figure 5 from Peptidomimetic Src/Pretubulin Inhibitor KX-01 Alone and in Combination with Paclitaxel Suppresses Growth, Metastasis in Human ER/PR/HER2-Negative Tumor Xenografts
Authors: Anbalagan Muralidharan , Ali Alaa , Jones Ryan K. , Marsden Carolyn G. , Sheng Mei , Carrier Latonya , Bu Yahao , Hangauer David , Rowan Brian G.
Published: April 2023

PDF file, 30K, Standard curve for number of human cells in mouse organs and quantification of micro-metastasis in KX-01 and doxorubicin combination treatment using real-time PCR for a human-specific α-satellite DNA sequence of the centromere region of human chromosome 17.
Supplementary Figure 3 from Peptidomimetic Src/Pretubulin Inhibitor KX-01 Alone and in Combination with Paclitaxel Suppresses Growth, Metastasis in Human ER/PR/HER2-Negative Tumor Xenografts
Authors: Anbalagan Muralidharan , Ali Alaa , Jones Ryan K. , Marsden Carolyn G. , Sheng Mei , Carrier Latonya , Bu Yahao , Hangauer David , Rowan Brian G.
Published: April 2023

PDF file, 388K, The body weights of mice were measured either once in a week or 10 days after treatment with vehicle, KX-01, PAX and KX-01 + PAX. Tumors obtained from tumor xenograft studies were fixed, paraffin embedded and sectioned. The slides were stained for H&E.
Supplementary Figures 1-8 from NMS-P937, an Orally Available, Specific Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies
Authors: Valsasina Barbara , Beria Italo , Alli Cristina , Alzani Rachele , Avanzi Nilla , Ballinari Dario , Cappella Paolo , Caruso Michele , Casolaro Alessia , Ciavolella Antonella , Cucchi Ulisse , De Ponti Anna , Felder Eduard , Fiorentini Francesco , Galvani Arturo , Gianellini Laura M. , Giorgini Maria L. , Isacchi Antonella , Lansen Jaqueline , Pesenti Enrico , Rizzi Simona , Rocchetti Maurizio , Sola Francesco , Moll Jürgen
Published: April 2023

PDF file - 1.2MB
Supplementary Figure 5 from Combining PARP-1 Inhibition and Radiation in Ewing Sarcoma Results in Lethal DNA Damage
Authors: Lee Hae-June , Yoon Changhwan , Schmidt Benjamin , Park Do Joong , Zhang Alexia Y. , Erkizan Hayriye V. , Toretsky Jeffrey A. , Kirsch David G. , Yoon Sam S.
Published: April 2023

PDF - 65KB, Growth of SK-N-MC flank tumors in athymic nude mice treated with 12-15 Gy.
Supplementary Figure Legends 1-2 from Autophagy Inhibition Synergistically Enhances Anticancer Efficacy of RAMBA, VN/12-1 in SKBR-3 Cells, and Tumor Xenografts
Authors: Godbole Abhijit M. , Purushottamachar Puranik , Martin Marlena S. , Daskalakis Constantine , Njar Vincent C.O.
Published: April 2023

PDF file - 69K
Supplementary Table 2 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Authors: Allen Wendy L. , Turkington Richard C. , Stevenson Leanne , Carson Gail , Coyle Vicky M. , Hector Suzanne , Dunne Philip , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 321K, List showing 2544 genes that are uniquely altered following SN38 treatment over time in HCT116 p53wild-type cells only. Genes have been normalised and filtered as stated in the materials and methods
Supplementary Methods from Induction of Endoplasmic Reticulum Stress by Sorafenib and Activation of NF-κB by Lestaurtinib as a Novel Resistance Mechanism in Hodgkin Lymphoma Cell Lines
Authors: Holz Meike Stefanie , Janning Angela , Renné Christoph , Gattenlöhner Stefan , Spieker Tilmann , Bräuninger Andreas
Published: April 2023

PDF file - 65K
Supplementary Table 1 from A 71-Gene Signature of TRAIL Sensitivity in Cancer Cells
Authors: Chen Jun-Jie , Knudsen Steen , Mazin Wiktor , Dahlgaard Jesper , Zhang Baolin
Published: April 2023

PDF file - 84K, Supplement I.
Supplementary Figure 9 from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 1.2MB
Supplementary Figure Legend from The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models
Authors: Mizuma Masamichi , Rasheed Zeshaan A. , Yabuuchi Shinichi , Omura Noriyuki , Campbell Nathaniel R. , de Wilde Roeland F. , De Oliveira Elizabeth , Zhang Qing , Puig Oscar , Matsui William , Hidalgo Manuel , Maitra Anirban , Rajeshkumar N.V.
Published: April 2023

PDF file, 94K.
Supplementary Figure 2 from The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models
Authors: Mizuma Masamichi , Rasheed Zeshaan A. , Yabuuchi Shinichi , Omura Noriyuki , Campbell Nathaniel R. , de Wilde Roeland F. , De Oliveira Elizabeth , Zhang Qing , Puig Oscar , Matsui William , Hidalgo Manuel , Maitra Anirban , Rajeshkumar N.V.
Published: April 2023

PDF file, 186K, Baseline gene expression profiles identify signatures of response to single agent MRK-003 and the combination of MRK-003 and GEM.
Supplementary Table 2 from Molecular Predictors of Sensitivity to the Insulin-like Growth Factor 1 Receptor Inhibitor Figitumumab (CP-751,871)
Authors: Pavlicek Adam , Lira Maruja E. , Lee Nathan V. , Ching Keith A. , Ye Jingjing , Cao Joan , Garza Scott J. , Hook Kenneth E. , Ozeck Mark , Shi Stephanie T. , Yuan Jing , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G.
Published: April 2023

PDF file - 51K, Figitumumab potency in 93 cell lines annotated by normalized mRNA expression of selected IGF pathway genes.
Supplementary Table 1 from A High-Throughput Panel for Identifying Clinically Relevant Mutation Profiles in Melanoma
Authors: Dutton-Regester Ken , Irwin Darryl , Hunt Priscilla , Aoude Lauren G. , Tembe Varsha , Pupo Gulietta M. , Lanagan Cathy , Carter Candace D. , O'Connor Linda , O'Rourke Michael , Scolyer Richard A. , Mann Graham J. , Schmidt Christopher W. , Herington Adrian , Hayward Nicholas K.
Published: April 2023

XLS file - 50K, Confirmation panel assay design.
Supplementary Methods from Inducible Silencing of Protein Kinase D3 Inhibits Secretion of Tumor-Promoting Factors in Prostate Cancer
Authors: LaValle Courtney R. , Zhang Liyong , Xu Shuping , Eiseman Julie L. , Wang Q. Jane
Published: April 2023

PDF file, 83KB.
Supplementary Figure 3 from Inducible Silencing of Protein Kinase D3 Inhibits Secretion of Tumor-Promoting Factors in Prostate Cancer
Authors: LaValle Courtney R. , Zhang Liyong , Xu Shuping , Eiseman Julie L. , Wang Q. Jane
Published: April 2023

PDF file, 457KB, The effect of PKD3 on cell migration is mediated through secreted factors in PC3 cells.
Supplementary Figure Legend from Identification and Characterization of MEL-3, a Novel AR Antagonist That Suppresses Prostate Cancer Cell Growth
Authors: Helsen Christine , Marchand Arnaud , Chaltin Patrick , Munck Sebastian , Voet Arnout , Verstuyf Annemieke , Claessens Frank
Published: April 2023

PDF file, 54KB.
Supplementary Figure 3 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
Authors: Liu Yi , Cao Yanyan , Zhang Weihe , Bergmeier Stephen , Qian Yanrong , Akbar Huzoor , Colvin Robert , Ding Juan , Tong Lingying , Wu Shiyong , Hines Jennifer , Chen Xiaozhuo
Published: April 2023

PDF file, 168KB, Intracellular ATP concentrations under different doses of extracellular ATP. time-dependence of extracellular ATP rescue of WZB117-treated cancer cells, and WZB117-induced autophagy.
Supplementary Figure 2 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
Authors: Liu Yi , Cao Yanyan , Zhang Weihe , Bergmeier Stephen , Qian Yanrong , Akbar Huzoor , Colvin Robert , Ding Juan , Tong Lingying , Wu Shiyong , Hines Jennifer , Chen Xiaozhuo
Published: April 2023

PDF file, 149KB, Body weight and blood glucose levels of tumor-bearing mice treated by WZB117.
Supplementary Figure 1 from Identification and Characterization of MEL-3, a Novel AR Antagonist That Suppresses Prostate Cancer Cell Growth
Authors: Helsen Christine , Marchand Arnaud , Chaltin Patrick , Munck Sebastian , Voet Arnout , Verstuyf Annemieke , Claessens Frank
Published: April 2023

PDF file, 25KB, AR-level in ClARE and SelARE.
Supplementary Figure 1 from Thermal Targeting of an Acid-Sensitive Doxorubicin Conjugate of Elastin-like Polypeptide Enhances the Therapeutic Efficacy Compared with the Parent Compound In Vivo
Authors: Moktan Shama , Perkins Eddie , Kratz Felix , Raucher Drazen
Published: April 2023

PDF file, 51KB, Tumor weight of the animals treated with equimolar dose of SynB1-ELP1-Dox and free Dox.
Supplementary Figure 6 from Reversing Effect of Ring Finger Protein 43 Inhibition on Malignant Phenotypes of human Hepatocellular Carcinoma
Authors: Xing Chunyang , Zhou Wuhua , Ding Songming , Xie Haiyang , Zhang Wu , Yang Zhe , Wei Bajin , Chen Kangjie , Su Rong , Cheng Jun , Zheng Shusen , Zhou Lin
Published: April 2023

PDF file - 7954K, Histology and IHC analysis of HCC xenografts. (a, b) Hematoxylin-eosin-stained sections of xenograft tumors (magnification �400). Mitotic cells (arrows) were quantified in five randomly chosen high-power fields (n=5, *p = 0.04). (c, d) CD31 stained sections of xenograft tumors (Original magnification �200). Microvessels (arrows) were quantified in five randomly chosen high-power fields (n=5, *p = 0.01). (e, f) Tumor sections measured by TUNEL staining (Original magnification �200). TUNEL-positive cells (arrows) were quantified in 5 randomly chosen high-power fields (n=5, *p = 0.03). (g, h) RNF43 stained sections of xenograft tumors.
Supplementary Figures 1-6 from Hsp90 Inhibitors Promote p53-Dependent Apoptosis through PUMA and Bax
Authors: He Kan , Zheng Xingnan , Zhang Lin , Yu Jian
Published: April 2023

PDF - 480KB, Figure S1. Levels of AKT, p-ERK and ERK change following 17AAG treatment; Figure S2. PUMA but not Bim is required for 17AAG-induced apoptosis in HCT 116 cells; Figure S3. PUMA is required for apoptosis induced by other Hsp90 inhibitors; Figure S4. p21 induction suppresses 17AAG-induced apoptosis; Figure S5. p53-KO HCT 116 cells are resistant to apoptosis induced by other Hsp90 inhibitors; Figure S6. 17AAG induces XBP1 splicing but XBP1 siRNA did not affect PUMA induction by 17AAG.
Supplemental Figure 3 from A Novel Monoclonal Antibody to Secreted Frizzled-Related Protein 2 Inhibits Tumor Growth
Authors: Fontenot Emily , Rossi Emma , Mumper Russell , Snyder Stephanie , Siamakpour-Reihani Sharareh , Ma Ping , Hilliard Eleanor , Bone Bradley , Ketelsen David , Santos Charlene , Patterson Cam , Klauber-DeMore Nancy
Published: April 2023

SFRP2 MAb binds to both human and mouse recombinant SFRP2 protein.
Supplementary Table 1 from A Recombinant Immunotoxin against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity
Authors: Weldon John E. , Xiang Laiman , Zhang Jingli , Beers Richard , Walker Dawn A. , Onda Masanori , Hassan Raffit , Pastan Ira
Published: April 2023

PDF file - 71K, In vitro cytotoxicity summary
Supplementary Figure 3 from A Recombinant Immunotoxin against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity
Authors: Weldon John E. , Xiang Laiman , Zhang Jingli , Beers Richard , Walker Dawn A. , Onda Masanori , Hassan Raffit , Pastan Ira
Published: April 2023

PDF file - 204K, Pharmacokinetics of SS1-LR/GGS/8M in mice
Supplementary Figure 2 from Poly(β-amino ester) Nanoparticle Delivery of TP53 Has Activity against Small Cell Lung Cancer In Vitro and In Vivo
Authors: Kamat Chandrashekhar D. , Shmueli Ron B. , Connis Nick , Rudin Charles M. , Green Jordan J. , Hann Christine L.
Published: April 2023

PDF file - 25 KB, The transfection efficiency of 456 polymers in two non-transformed human lung fibroblast cell lines.
Supplementary Figure Legend from Effect of Small-Molecule–Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody
Authors: Orcutt Kelly Davis , Rhoden John J. , Ruiz-Yi Benjamin , Frangioni John V. , Wittrup K. Dane
Published: April 2023

PDF file, 64KB.
Supplementary Table 1 from CDK-4 Inhibitor P276 Sensitizes Pancreatic Cancer Cells to Gemcitabine-Induced Apoptosis
Authors: Subramaniam Dharmalingam , Periyasamy Giridharan , Ponnurangam Sivapriya , Chakrabarti Debarshi , Sugumar Aravind , Padigaru Muralidhara , Weir Scott J. , Balakrishnan Arun , Sharma Somesh , Anant Shrikant
Published: April 2023

PDF file, 709KB, The list of primers used for Real Time RT-PCR are shown in this table.
Supplementary Figure 4 from Synergistic Targeting of PI3K/AKT Pathway and Androgen Receptor Axis Significantly Delays Castration-Resistant Prostate Cancer Progression In Vivo
Authors: Thomas Christian , Lamoureux Francois , Crafter Claire , Davies Barry R. , Beraldi Eliana , Fazli Ladan , Kim Soojin , Thaper Daksh , Gleave Martin E. , Zoubeidi Amina
Published: April 2023

PDF - 132KB, Effect of AZD5363 on nuclear translocation of AR
Supplementary Figure 3 from Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib
Authors: Kalous Ondrej , Conklin Dylan , Desai Amrita J. , O'Brien Neil A. , Ginther Charles , Anderson Lee , Cohen David J. , Britten Carolyn D. , Taylor Ian , Christensen James G. , Slamon Dennis J. , Finn Richard S.
Published: April 2023

PDF file, 75K, Dacomitinib response is marginally inversely correlated with relative HER3 mRNA levels.
Supplementary Figure 2 from microRNA-9 Targets Matrix Metalloproteinase 14 to Inhibit Invasion, Metastasis, and Angiogenesis of Neuroblastoma Cells
Authors: Zhang Huanyu , Qi Meng , Li Shiwang , Qi Teng , Mei Hong , Huang Kai , Zheng Liduan , Tong Qiangsong
Published: April 2023

PDF file, 19KB, MMP-14 directly regulated the VEGF expression in NB cells.
Supplementary Figure 1 from microRNA-9 Targets Matrix Metalloproteinase 14 to Inhibit Invasion, Metastasis, and Angiogenesis of Neuroblastoma Cells
Authors: Zhang Huanyu , Qi Meng , Li Shiwang , Qi Teng , Mei Hong , Huang Kai , Zheng Liduan , Tong Qiangsong
Published: April 2023

PDF file, 60KB, Distribution of miR-9 in the NB tissues.
Supplementary Figure Legend from Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening
Authors: Rickles Richard J. , Tam Winnie F. , Giordano Thomas P. , Pierce Laura T. , Farwell Melissa , McMillin Douglas W. , Necheva Antoaneta , Crowe David , Chen Mei , Avery William , Kansra Vikram , Nawrocki Steffan T. , Carew Jennifer S. , Giles Francis J. , Mitsiades Constantine S. , Borisy Alexis A. , Anderson Kenneth C. , Lee Margaret S.
Published: April 2023

PDF file, 85KB.
Supplementary Figure 1 from Induction of the Transcriptional Repressor ZBTB4 in Prostate Cancer Cells by Drug-Induced Targeting of MicroRNA-17-92/106b-25 Clusters
Authors: Kim KyoungHyun , Chadalapaka Gayathri , Pathi Satya S. , Jin Un-Ho , Lee Ju-Seog , Park Yun-Yong , Cho Sung-Gook , Chintharlapalli Sudhakar , Safe Stephen
Published: April 2023

PDF file, 42K, Data mining for ZBTB4 expression.
Supplementary Table 1 from Quantitative Proteomic Profiling Identifies Protein Correlates to EGFR Kinase Inhibition
Authors: Kani Kian , Faca Vitor M. , Hughes Lindsey D. , Zhang Wenxuan , Fang Qiaojun , Shahbaba Babak , Luethy Roland , Erde Jonathan , Schmidt Joanna , Pitteri Sharon J. , Zhang Qing , Katz Jonathan E. , Gross Mitchell E. , Plevritis Sylvia K. , McIntosh Martin W. , Jain Anjali , Hanash Samir , Agus David B. , Mallick Parag
Published: April 2023

PDF file, 3.66MB, Proteomic data table. Tabular list of proteomic data from the 2 hr and 16 hour gefitinib treated experiments. Whole cell lysate (WCL), cell-surface (SUR), and SPEG/GC.
Supplementary Figure S2 from miRNA-100 Inhibits Human Bladder Urothelial Carcinogenesis by Directly Targeting mTOR
Authors: Xu Chuanliang , Zeng Qinsong , Xu Weidong , Jiao Li , Chen Yanqiong , Zhang Zhensheng , Wu Chengyao , Jin Taile , Pan Anyin , Wei Rongchao , Yang Bo , Sun Yinghao
Published: April 2023

PDF file - 150KB, MicroRNA target significant GO. The high-enrichment GOs targeted by the interested miRNAs: the vertical axis is the GO category and the horizontal axis is the -log2 treated of the P values of the enrichment of GO.
Supplementary Figure 2 from Quantitative Proteomic Profiling Identifies Protein Correlates to EGFR Kinase Inhibition
Authors: Kani Kian , Faca Vitor M. , Hughes Lindsey D. , Zhang Wenxuan , Fang Qiaojun , Shahbaba Babak , Luethy Roland , Erde Jonathan , Schmidt Joanna , Pitteri Sharon J. , Zhang Qing , Katz Jonathan E. , Gross Mitchell E. , Plevritis Sylvia K. , McIntosh Martin W. , Jain Anjali , Hanash Samir , Agus David B. , Mallick Parag
Published: April 2023

PDF file, 321KB, Protein levels changes associated with EGFR targeted and non-EGFR targeted drugs.
Supplementary Figure 1 from Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival
Authors: Wilsker Deborah , Chung Jon H. , Pradilla Ivan , Petermann Eva , Helleday Thomas , Bunz Fred
Published: April 2023

PDF file - 74K, Effect of CDK2 on DNA replication fork dynamics. Replicating DNA was sequentially labeled with CIdU (red) and IdU (green), and the length of double-labeled DNA fibers were measured via confocal microscopy. (A) Distribution of fork rates in unperturbed HCT116 cells and the CDK2-/- derivative cell line. (B) Average fork rates in HCT116 parental and CDK2-/- cells. ** denotes significance (One-tailed paired Student's t-test, p<009). (C) Proportion of labeled fibers that represent replication origins and terminations. Colored arrows represent orientation of replicons.
Supplementary Materials and Methods from Inhibiting Aurora Kinases Reduces Tumor Growth and Suppresses Tumor Recurrence after Chemotherapy in Patient-Derived Triple-Negative Breast Cancer Xenografts
Authors: Romanelli Angela , Clark Anderson , Assayag Franck , Chateau-Joubert Sophie , Poupon Marie-France , Servely Jean-Luc , Fontaine Jean-Jacques , Liu Xiaohong , Spooner Edward , Goodstal Samantha , de Cremoux Patricia , Bièche Ivan , Decaudin Didier , Marangoni Elisabetta
Published: April 2023

PDF file - 108 KB, This file provides additional details on methods and protocols.
Supplementary Figure Legends from Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways
Authors: Aarts Marieke , Bajrami Ilirjana , Herrera-Abreu Maria T. , Elliott Richard , Brough Rachel , Ashworth Alan , Lord Christopher J. , Turner Nicholas C.
Published: April 2023

This file contains the legends for Supplementary Figures S1-S6.
Data Supplement from NEO212, Temozolomide Conjugated to Perillyl Alcohol, Is a Novel Drug for Effective Treatment of a Broad Range of Temozolomide-Resistant Gliomas
Authors: Cho Hee-Yeon , Wang Weijun , Jhaveri Niyati , Lee David Jungpa , Sharma Natasha , Dubeau Louis , Schönthal Axel H. , Hofman Florence M. , Chen Thomas C.
Published: April 2023

Supplementary Figure Legends
Supplementary Figure Legends from Transcriptomic and Protein Expression Analysis Reveals Clinicopathological Significance of Bloom Syndrome Helicase (BLM) in Breast Cancer
Authors: Arora Arvind , Abdel-Fatah Tarek M.A. , Agarwal Devika , Doherty Rachel , Moseley Paul M. , Aleskandarany Mohammed A. , Green Andrew R. , Ball Graham , Alshareeda Alaa T. , Rakha Emad A. , Chan Stephen Y.T. , Ellis Ian O. , Madhusudan Srinivasan
Published: April 2023

Supplementary Figure S1: BLM m RNA and breast cancer (external validation cohort). Supplementary Figure S2: Western blots and immunohistochemistry. Supplementary Figure S3: BLM protein expression and survival. Supplementary Figure S4: BLM-Rad51 co-expression and survival. Supplementary Figure S5: BLM-Rad51 co-expression and survival in ER+ breast cancers.
Supplementary Tables 1 through 3 and Supplementary Figures 1 through 6 from The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers
Authors: van der Lee Miranda M.C. , Groothuis Patrick G. , Ubink Ruud , van der Vleuten Monique A.J. , van Achterberg Tanja A. , Loosveld Eline M. , Damming Désirée , Jacobs Daniëlle C.H. , Rouwette Myrthe , Egging David F. , van den Dobbelsteen Diels , Beusker Patrick H. , Goedings Peter , Verheijden Gijs F.M. , Lemmens Jacques M. , Timmers Marco , Dokter Wim H.A.
Published: April 2023

Table S1. Summary of status of tumors used in cell line and patient-derived xenograft models. Table S2. SYD985 and T-DM1 IC50, 95% confidence interval and % efficacy values from the in vitro cytotoxicity assays as depicted in Figure 1B. Table S3. Pharmacokinetic parameters for ADC (SYD985 and T-DM1) in BT-474-tumor-bearing mice after a single i.v. bolus injection of ADC. Figure S1. In vitro cytotoxicity. Figure S2. A-G HER2 expression in BT-474. Figure S3. HER2 cell surface expression quantified on a panel of 8 cell lines using the DAKO Qifikit. Figure S4. In vitro cytotoxicity. Figure S5. In vitro bystander killing. Figure S6. Mean ADC (SYD985 conjugated antibody) concentrations in plasma in carboxylesterase CES1c knock-out (-/-) , CES1c heterozygeous (+/-) and CES1c wild type (+/+) mice, after single i.v. bolus injection of SYD985 at 5 mg/kg (+/- SEM, n = 3).
Supplementary Methods, Figure Legends 1-2 from Context Dependence of Checkpoint Kinase 1 as a Therapeutic Target for Pancreatic Cancers Deficient in the BRCA2 Tumor Suppressor
Authors: Hattori Hiroyoshi , Skoulidis Ferdinandos , Russell Paul , Venkitaraman Ashok R.
Published: April 2023

Supplementary Methods, Figure Legends 1-2 from Context Dependence of Checkpoint Kinase 1 as a Therapeutic Target for Pancreatic Cancers Deficient in the BRCA2 Tumor Suppressor
Supplementary Figure 3 from miR200c Attenuates P-gp–Mediated MDR and Metastasis by Targeting JNK2/c-Jun Signaling Pathway in Colorectal Cancer
Authors: Sui Hua , Cai Guo-Xiang , Pan Shu-Fang , Deng Wan-Li , Wang Yu-Wei , Chen Zhe-Sheng , Cai San-Jun , Zhu Hui-Rong , Li Qi
Published: April 2023

Supplementary Figure 3: Supplementary data for Figure 3 of the manuscript.
Supplementary Figure 2 from miR200c Attenuates P-gp–Mediated MDR and Metastasis by Targeting JNK2/c-Jun Signaling Pathway in Colorectal Cancer
Authors: Sui Hua , Cai Guo-Xiang , Pan Shu-Fang , Deng Wan-Li , Wang Yu-Wei , Chen Zhe-Sheng , Cai San-Jun , Zhu Hui-Rong , Li Qi
Published: April 2023

Supplementary Figure 2: Relative expression levels of miR-200c in MDR cells and their parental cells.
Supplementary Figure 1 from miR200c Attenuates P-gp–Mediated MDR and Metastasis by Targeting JNK2/c-Jun Signaling Pathway in Colorectal Cancer
Authors: Sui Hua , Cai Guo-Xiang , Pan Shu-Fang , Deng Wan-Li , Wang Yu-Wei , Chen Zhe-Sheng , Cai San-Jun , Zhu Hui-Rong , Li Qi
Published: April 2023

Supplementary Figure 1: miRNAs in the parental cells with those of MDR cells in colorectal cancer using miRNA microarray.
Supplementary Table S3 from Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma
Authors: Shirota Tomoki , Ojima Hidenori , Hiraoka Nobuyoshi , Shimada Kazuaki , Rokutan Hirofumi , Arai Yasuhito , Kanai Yae , Miyagawa Shinichi , Shibata Tatsuhiro
Published: April 2023

IC50 inhibition values for NVP-AUY922
Supplementary Figure S1 from Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma
Authors: Shirota Tomoki , Ojima Hidenori , Hiraoka Nobuyoshi , Shimada Kazuaki , Rokutan Hirofumi , Arai Yasuhito , Kanai Yae , Miyagawa Shinichi , Shibata Tatsuhiro
Published: April 2023

Disease free survival according to HSP90 expression
Supplementary Table 2 from Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia
Authors: Liao Zhiyong , Gu Lei , Vergalli Jenny , Mariani Samanta A. , De Dominici Marco , Lokareddy Ravi K. , Dagvadorj Ayush , Purushottamachar Puranik , McCue Peter A. , Trabulsi Edouard , Lallas Costas D. , Gupta Shilpa , Ellsworth Elyse , Blackmon Shauna , Ertel Adam , Fortina Paolo , Leiby Benjamin , Xia Guanjun , Rui Hallgeir , Hoang David T. , Gomella Leonard G. , Cingolani Gino , Njar Vincent , Pattabiraman Nagarajan , Calabretta Bruno , Nevalainen Marja T.
Published: April 2023

Supplementary Table 2: Genes regulated by both Stat5-shRNA and IST5-002 in K562 cells, corresponding to the heatmap in Figure 2g.
Supplementary Methods; Supplementary Figures 1 through 9 from Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia
Authors: Liao Zhiyong , Gu Lei , Vergalli Jenny , Mariani Samanta A. , De Dominici Marco , Lokareddy Ravi K. , Dagvadorj Ayush , Purushottamachar Puranik , McCue Peter A. , Trabulsi Edouard , Lallas Costas D. , Gupta Shilpa , Ellsworth Elyse , Blackmon Shauna , Ertel Adam , Fortina Paolo , Leiby Benjamin , Xia Guanjun , Rui Hallgeir , Hoang David T. , Gomella Leonard G. , Cingolani Gino , Njar Vincent , Pattabiraman Nagarajan , Calabretta Bruno , Nevalainen Marja T.
Published: April 2023

Supplementary Methods. Supplementary Figure 1. Chemical structures of the small molecule IST5-002 analogs. Supplementary Figure 2. IST5-002 inhibits phosphorylation of Stat5 in mouse and human breast cancer cells. Supplementary Figure 3. IST5-002 does not have significant inhibitory activity against 50 kinases tested. Supplementary Figure 4. IST5-002 does not affect phosphorylation of Pak1/2. Supplementary Figure 5. IST5-002 inhibits expression of Stat5 target genes in PC cells and in CML cells. Supplementary Figure 6. IST5-002 is not generally cytotoxic as determined by lack of cell death induction in cancer cell lines established from other organs. Supplementary Figure 7. CWR22Rv1 PC cells were inoculated subcutaneously into the flanks of castrated athymic nude mice supplied with sustained-release 5alpha-dihydrotestosterone (DHT)-pellets (n=10/group, 1 tumor/mouse, 1.5 ??107 CWR22Rv1 cells per site, 1 DHT pellet/mouse). Supplementary Figure 8. IST5-0-02 induces apoptosis in CWR22Rv1 tumors grown in nude mice and in clinical PCs cultured ex vivo in organ explant cultures. Supplementary Figure 9. IST5-002 induces extensive apoptotic death of imatinib-sensitive and -resistant CML cells.
Supplementary Figure 2 from Significance of Polypyrimidine Tract–Binding Protein 1 Expression in Colorectal Cancer
Authors: Takahashi Hidekazu , Nishimura Junichi , Kagawa Yoshinori , Kano Yoshihiro , Takahashi Yusuke , Wu Xin , Hiraki Masayuki , Hamabe Atsushi , Konno Masamitsu , Haraguchi Naotsugu , Takemasa Ichiro , Mizushima Tsunekazu , Ishii Masaru , Mimori Koshi , Ishii Hideshi , Doki Yuichiro , Mori Masaki , Yamamoto Hirofumi
Published: April 2023

(A) Representative immunohistochemical analysis of clinical samples. Scale bar: 100 ÃŽÂ¼m. (B) Correlation between mRNA and protein levels of PTBP1 in clinical specimens. PTBP1 low-expression group determined by immunohistochemistry (n = 5) also had significantly lower PTBP1 mRNA levels than the PTBP1 protein high-expression group (n = 11) (P = 0.012).
Supplemental Figure 3 from An Oral Formulation of YK-4-279: Preclinical Efficacy and Acquired Resistance Patterns in Ewing Sarcoma
Authors: Lamhamedi-Cherradi Salah-Eddine , Menegaz Brian A. , Ramamoorthy Vandhana , Aiyer Ramani A. , Maywald Rebecca L. , Buford Adrianna S. , Doolittle Dannette K. , Culotta Kirk S. , O'Dorisio James E. , Ludwig Joseph A.
Published: April 2023

Supplemental Figure 3. The YK-resistant clone (TC71#3)displayed cross resistance to imatinib
Supplementary Table 3 from p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer
Authors: Tentler John J. , Ionkina Anastasia A. , Tan Aik Choon , Newton Timothy P. , Pitts Todd M. , Glogowska Magdalena J. , Kabos Peter , Sartorius Carol A. , Sullivan Kelly D. , Espinosa Joaquin M. , Eckhardt S. Gail , Diamond Jennifer R.
Published: April 2023

Supplementary Table 3: Quantification of total cell counts and average cellular size under conditions depicted in Fig. 4A.