bluuebunny/crossref_metadata_2025 huggingface dataset:
An Evaluation of the Autopsy Cases of Carbon monoxide Poisoning in Trabzon Between 2009-2016
Authors: Ketenci Hüseyin Çetin , Karadeniz Hülya , Boz Halil , Beyhun Nazım Ercüment
Published: December 2018

Objective: Carbon monoxide related deaths, which are generally preventable accidents, and more common when compared with other toxic substance consumption, arouse public attention in our country.
Materials and Methods: In this study, the aim is to investigate different features of carbon monoxide poisoning related deaths autopsied in Trabzon in 8-year period of time and demonstrate medico-legal aspects of this issue.
Results: Our study consists of all deaths due to carbon monoxide poisoning and autopsied by Trabzon Morgue Department of the Council of Forensic Medicine of Turkey between 2009 and 2016. Records of a total of 7133 criminal cases who were autopsied between these years were examined and 215 cases who died due to CO poisoning were evaluated for age, sex, the month of the event occurred, origin, death time, CO source and carboxyhemoglobin (COHb) values. 215 criminal cases were constituting 3.01% of 7133 criminal cases who were autopsied within 8 years in Trabzon. 91 of the cases were (42.3%) female and 124 were (57.7%) male and the male/female case ratio was 1.4. Mean age of the cases was 48.8±27.1years. 24.1% of deaths occurred in January 74% at home. CO source was found to be charcoal in 55.3% of cases. Mean COHb level detected in cases was 54.9±17.6%.
Conclusion: Carbon monoxide poisoning is an important social problem in our country as in many developing countries. It is concluded that with their medicolegal experiences and suggestions, forensic medicine specialists can play an important role to manage carbon monoxide poisonings which are mainly...
Dedektif Romanları: Tarihine Sığmayan Geçmişi İle Türkiye’de ve Dünyada Adli Edebiyat
Authors: Ağaoğlu Reyyan , Oral Gökhan
Published: December 2018

Language and discourse constitute a whole; literature, which forms a part of discourse through literary works and suggests an idea about so many facts just like historical, social and psychological events, is studied by other disciplines besides Linguistics; Forensic Science, having a multidisciplinary feature, is one of them. As the detective fiction forms a part of literature, the relationship of this part with Forensic Sciences inevitably remains at the forefront. Throughout the emergence of human beings, crime occupies a place in the life of the mankind and this issue manifests itself in literary works. The detective fiction, formed through crime-criminal-detective triangle, is a source by which Forensic Sciences profit. This study is carried out to investigate developmental stages of the detective fiction by assessing the position of the detective fiction in Turkish and world literature.
In the scope of the study, a literature review was made and developmental stages of the detective fiction in Turkish and world literature were traced. In this regard, a qualitative study was prepared and a chronological schema which reveals the most important and lively works of Turkish and world literature was created.
At the end of the study, it was learned that the detective fiction emerged through police power and the policemen and the detectives, who had left their marks in history, set light to literary works which still remain a mystery.
Conciencia y Derecho: Conferencia pronunciada por el padrino de la promoción anual de la Facultad de Derecho el día de la festividad de San Raimundo de Peñafort = Awareness and Law: Conference given by the sponsor of the annual promotion of the Faculty of Law on the day of the feast of St. Raimundo de Peñafort
Authors: Llamazares Fernández Dionisio
Published: December 2018

La relación entre conciencia y Derecho es mucho más estrecha que la que se reduce a los supuestos de objeción de conciencia. Desde una perspectiva transversal, la conciencia es la columna vertebral de los estudios jurídicos, e incluso de la actividad de todos los operadores  jurídicos. El presente artículo desarrolla tres aspectos de esta relación: la presencia protagonista del derecho de libertad de conciencia en el pacto por la convivencia, base misma del  Derecho; su  presencia igualmente protagonista en la vertebración de las libertades públicas y de los derechos fundamentales (derechos subjetivos); y su papel como principio informador de la estructura y dinamismo del ordenamiento. Finalmente, el artículo concluye subrayando el papel trascendental del derecho a la libre formación de la conciencia como elemento integrante básico y original del derecho de libertad de conciencia.The relationship between the conscience and the law is not limited to cases of conscientious objection. From a transversal perspective, conscience is the backbone of legal studies and the activity developed by legal operators. This paper studies three aspects of the relationship between conscience and Law: the right of freedom of conscience in the social coexistence pact, which in one of the bases of the legal system; the presence of freedom of conscience in the organization of the model of public liberties and fundamental rights; and the role of freedom of conscience as an informing principle of the legal system Finally, the paper concludes underlining the transcendental role of the right to the free formation of conscience, as a basic and original component of the right to freedom of conscience.
La armonización fiscal de los impuestos especiales = The fiscal harmonization of special taxes
Authors: Mata Sierra María Teresa
Published: December 2018

Este artículo doctrinal analiza el estado de la armonización fiscal de los impuestos especiales o accisas, en denominación comunitaria, poniendo de evidencia que todavía queda mucho por hacer.This essay tries to analyze the fiscal harmonization of the Excises duties or accisas, in community name, putting of evidence that still remains great for doing.
À propos du statut constitutionnel de l’assurance vieillesse française = Sobre el estatuto constitucional del seguro francés de vejez= About the constitutional status of French old-age insurance
Authors: Barra Juliano
Published: December 2018

Pouvons-nous affirmer l’existence d’un régime juridique constitutionnel pour les retraites de base française? Quelle est l’importance de la jurisprudence du Conseil constitutionnel en matière d’assurance vieillesse? Comment, en effet, le Conseil constitutionnel appréhende-t-il les changements de la législation des retraites dans un sens moins favorable aux assurés à l’aune de la théorie du cliquet anti-retour? Les retraites de base de la sécurité sociale peuvent-elles être perçues à partir de la notion de droit de propriété? Comprendre l’existence ou non d’un statut constitutionnel concernant les prestations de retraite en France permettra d’établir quelques réponses à partir de l’analyse de la jurisprudence de son Conseil constitutionnel.Can we affirm the existence of a constitutional regime for the French retirement system? What is the importance of the jurisprudence of the «Conseil constitutionnel»? How does the “Conseil constitutionnel” apply the anti-return theory (théorie du cliquet anti-retour)? Can pensions be qualified from the concept of property rights? The answers of the existence or not of a constitutional regime for the French retirement system can be found in the decisions of the «Conseil constitutionnel».
Los estudios de derecho en Alemania: un ejemplo de formación jurídica al margen del sistema de Bolonia = The studies of law in Germany: An example of legal formation at the margin of the Bologna system
Authors: García Mosquera Marta
Published: December 2018

Una de las principales características del denominado "proceso de Bolonia" consiste en ordenar los estudios universitarios a partir de dos fases principales: Grado y Máster. En Alemania, sin embargo, los estudios de Derecho no se han sometido a este proceso, sino que han optado por mantener esencialmente su estructura tradicional. El trabajo pretende dar a conocer los rasgos fundamentales de la formación jurídica en Alemania y reflexionar sobre las consecuencias básicas que de ahí se derivan para las principales profesiones jurídicas: judicatura, fiscalía y abogacía.One of the main characteristics of the so-called "Bologna process" consists of implementing the two-tier structure in university studies: Bachelor and Master. Nevertheless German did not join the Bologna Process in law studies, but have chosen to essentially keep their previous traditional structure. The paper aims to raise awareness of the fundamental features of legal education in Germany and to reflect on the basic consequences that derive from this for the main legal professions: the judiciary, the prosecutor's office and the attorney.
Hacia la “parlamentarización” de los Presupuestos Generales del Estado: visión crítica de la sentencia del Tribunal Constitucional 34/2018, de 12 de abril
Authors: Alonso García María Nieves
Published: December 2018

Hacia la “parlamentarización” de los Presupuestos Generales del Estado
Entre a doutrina da situação irregular e a da proteção integral: o conceito de vulnerabilidade e a aplicação de medidas socioeducativas a partir da jurisprudência do Superior Tribunal de Justiça
Authors: Motta Costa Ana Paula , Safi Sofia De Souza Lima , Pamplona Roberta Silveira
Published: December 2018

A partir da problematização da noção de vulnerabilidade social enquanto possível herança da doutrina da situação irregular, o presente trabalho estuda a utilização desse termo nos processos de ato infracional, buscando verificar em quais situações ele é utilizado. Tal trabalho justifica-se diante da mudança de paradigma que ocorreu no olhar sobre a juventude a partir do Estatuto da Criança e do Adolescente. Para tanto, foi realizada uma pesquisa nas decisões do Superior Tribunal de Justiça que tratavam do tema. Primeiramente, foi realizada uma classificação inicial em que se percebeu que o aspecto do jovem mais utilizado nas decisões que definiram uma situação de vulnerabilidade era o envolvimento com outros atos infracionais ou o “envolvimento tidos como moralmente escusos”. Constatou-se, ainda, a utilização do termo como forma de abarcar situações abstratas da vida dos jovens. Por fim, verificou-se que a situação de vulnerabilidade pode servir de fundamento para a aplicação de uma medida socioeducativa mais gravosa.
La centralidad del parlamento. Una teoría crítica de sus funciones
Authors: Villadangos María Esther Seijas
Published: December 2018

La defensa del carácter esencial del Parlamento en las sociedades democráticas contemporáneas es compatible con la propuesta de la necesidad de su reforma. En este trabajo se analiza esa relación paradójica, desarrollando un especial interés en las siguientes propuestas. El objetivo fundamental de cualquier reforma que se postule sobre el Parlamento ha de ceñirse a reivindicar su mayor protagonismo en la esfera pública y en la política. En lo que concierne a la función legislativa cabe postular una reforma sustantiva y otra procesal. Sustantivamente, el Parlamento debe recuperar el protagonismo legislativo, reduciendo la intervención del ejecutivo en la función normativa, estableciendo unos límites más estrictos cuantitativamente y cualitativamente a la excepcionalidad reguladora del ejecutivo. Procesalmente, hemos de señalar la necesidad de limitar los procedimientos de lectura única, que han de vincularse a cuestiones sencillas y marcadas por el consenso mayoritario. Vinculada a esa función legislativa se analizará la presupuestaria. El papel de los Parlamentos en la tramitación presupuestaria tiene que cualificarse. La función de integración debe ser prioritaria en un contexto de Parlamentos fragmentados. Desde ella ha de potenciarse el papel de los Parlamentos en la resolución de conflictos, incluidos los territoriales. La participación, el Parlamento participado, es el referente de cualquier otra reforma. Su presencia es transversal a la modificación de todas las funciones especificadas. Es decir, el protagonismo del Parlamento como baluarte de la esencia del Estado democrático del siglo XXI.
Numerical simulation of low liquid flow in a mixer consisting of two centrifugal swirlers
Authors: Semkin E. V.
Published: December 2018

The paper describes a procedure of numerical simulation of operating fluid (water) discharge into the air environment through the hydraulic paths of a mixer composed of two low-flow coaxial swirl injectors. The method is based on a two-velocity model of a two-phase liquid flow and determining the interface interaction resistance coefficient versus the Reynolds number in the course of solution. The Reynolds number is calculated from the relative velocity of the liquid components forming the two-phase flow. The paper investigates variations in the mixer spray pattern versus two characteristic dimensions reckoned among the key parameters to calculate the coefficient of interface interaction resistance. Algorithms of calculating the coefficient of interface interaction resistance are proposed. The results of modeling liquid mixing and film flow breakdown within and beyond the mixer hydraulic paths for different values of the characteristic dimensions are presented. It is shown that we can achieve the conformity of the calculation results obtained by using the proposed method with the cold flow data by selecting the values of characteristic dimensions with reference to which interface interaction resistance coefficients are determined. Further works are projected.
Características dos materiais utilizados como barreira cervical na revascularização pulpar: uma revisão integrativa
Authors: Valença Jussara Santos , Prado Maira
Published: December 2018

Objetivo: realizar uma revisão integrativa sobre as características dos materiais utilizados como barreira cervical na revascularização pulpar, abordando a bioatividade e biocompatibilidade, bem como as desvantagens inerentes ao seu uso. Material e Métodos: foram feitas buscas, em inglês e português, nas plataformas PubMed e o Google Acadêmico. Foram utilizadas as seguintes palavras-chave: (revascularização da polpa OR regeneração da polpa) e (Biodentina OR Endosequence OR MTA Angelus OU Mistura Enriquecida com Cálcio OU ProRoot MTA) e (desenho OU descoloração) e (Biodentina OU Endosequence OU MTA Angelus OU Mistura Enriquecida com Cálcio OU ProRoot MTA). Os critérios de inclusão foram: artigos publicados de 2008 a 2018, estudos in vitro, estudos clínicos, revisão de literatura e relato de casos. Os critérios de exclusão foram: artigos que não abordar o tema da revascularização. Resultados: a busca eletrônica encontrou 337 artigos. Após a análise do título, 81 artigos foram selecionados para a leitura dos resumos, e 66 artigos foram excluídos de acordo com os critérios de inclusão. Após a leitura completa dos 15 artigos, 2 foram excluídos por não abordarem o tema deste estudo. Os periódicos foram encontrados: Dental Materials, International Endodontic Journal, Journal of Applied Oral Science, Journal of Dentistry of Tehran University of Medical Sciences, Journal of Endodontia e Revista de Ciências Médicas, de 2010 a 2017. Conclusão: materiais biocerâmicos utilizados como barreira cervical mostraram bioatividade e redução da toxicidade. Como um inconveniente para o seu uso, descoloração coronária é relatada in vitro devido ao MTA, Biodentine e Endosequence, e in vivo apenas devido ao MTA. Além disso, mineralizado tecido pode se formar dentro do canal radicular, possivelmente devido à bioatividade desses materiais.
Peri-Implant Diseases: an update for dentistry
Authors: Soares Álvaro Cavalheiro , Filgueiras Andreza Maria De Oliveira , Azevedo Viviane Vargas de , Benevides Marcus Vinicius Rêgo , Santos Bruna Michalski dos , Bastos Luciana Freitas , Faria Marcelo Daniel Brito , Ramos Ruth Tramontani , Cantisano Marilia Heffer
Published: December 2018

Objetivo: este estudo tem como objetivo apresentar e descrever as principais alterações patológicas, benignas e malignas da mucosa peri-implantar. Material e Métodos: uma revisão integrativa da literatura foi realizada utilizando os seguintes descritores: patologia peri-implantar; implante dentário de lesão reativa; implante dentário de carcinoma; implante dentário de doença peri-implantar; lesão reativa por implante dentário; carcinoma oral de células escamosas ao redor de implantes dentários; doença peri-implantar; patologia; para a elaboração da estratégia de busca nas bases de dados PubMed, LILACS, MEDLINE e SciElo para obtenção das produções científicas. Resultados: condições como mucosite peri-implantar e peri-implantite são pouco relatadas na literatura, o que dificulta a estimativa de sua real prevalência. Dentre as lesões reativas benignas, destacam-se o granuloma piogênico e o granuloma periférico de células gigantes, descritos como os mais frequentemente associados aos implantes. Em relação à neoplasia, foram publicados casos de hemangioma e CECO, sugerindo uma possível influência do implante no desenvolvimento dessas condições. Conclusão: a ocorrência de diversas patologias associadas a implantes dentários foi observada na literatura, o que demonstra a importância de um exame clínico detalhado, associado, em determinadas situações, a exame histopatológico para um diagnóstico acurado e manejo adequado das diversas doenças peri-implantares
Impact of long-term therapy with eprosartan on the structural and functional state of the heart and large vessels and on the autonomic regulation of circulation in patients with arterial hypertension
Authors: Yakovleva O. I. , Mamontov O. V. , Yakovlev A. N. , Vakhromeyeva N. V. , Konradi A. O.
Published: December 2018

To examine the effects of eprosartan on the remodelling of the heart and large vessels, on endothelial dysfunction and autonomic circulatory regulation in patients with hypertensive disease, thirteen patients were included into the study: Doppler echocardiographic study and evaluation of left ventricular diastolic function were performed on a Vingmed CFM800 apparatus: the thickness of the carotid intima-media complex and the diameter of the brachial artery were determined on the same apparatus using a 7.5-MHz transducer in the reactive hyperemia test. Automatic balance was evaluated by the spectral assay of cardiac rhythm variations. The cardiopulmonary component of baroreflex was also tested. Blood pressure normalized in 3 patients following 24 weeks of therapy with eprosartan in a daily dose of 600 mg. Two patients were excluded due to therapeutic inefficiency. In the remaining patients, the antihypertensive effect was incomplete. The mass of the left myocardial myocardium decreased by 10.8%. there was an increase in brachial arterial dilatation in the reactive hyperemia test. The variations of cardiac rhythm were not significantly changed, the baroreflex tended to be decreased. Thus, long-term eprosartan therapy improves the structural and functional state of the heart and vessels and fails to affect the autonomic regulation of circulation.
Obstructive sleep apnea syndrome is a risk factor for arterial hypertension
Authors: Kalinkin A. L.
Published: December 2018

The obstructive sleep apnea syndrome (OSAS) is a risk factor for cardiovascular diseases The results of epidemiological, observational, and experimental studies support the fact that OSAS is of considerable importance in the development of arterial hypertension via chronic sympathetic activation and sleep-induced neurohumoral changes OSAS is of prime importance in the development of refractory AH CPAP therapy not only eliminates sleep-induced obstructive respiratory impairments, but frequently lowers blood pressure in hypertensive patients, and improves the prognosis of cardiovascular diseases
May the development of type 2 diabetes mellitus be prevented: Results of the Stop-NDDM sudy
Authors: Chazova I. Ye.
Published: December 2018

There are about 150 million patients with diabetes mellitus (DM) in the world and their number will double by 2025. The occurrence of a complete clinical picture of type DM follows a period of glucose intolerance (GI). Enhancing insulin sensitivity and thus affecting GI may prevent the development of type 2 DM and reduce a risk of cardiovascular events. Acarbose (glucobay) is one of the drugs that affect insulin resistance. In the Stop-NDDM study enrolled patients with NI and obesity treated with acarbose for 3 years, the relative risk of type 2 DM decreased by 25% as compared with that in the placebo group. Active therapy caused a reduction in the relative risk of myocardial infarction by 91%, myocardial revascularization procedures by 39%, cerebrovascular disorders and stroke by 44%, and cardiovascular death by 45%.
Effects of indapamid retard on cardiovascular remodeling processes in patients with arterial hypertension
Authors: Ivanenko V. V. , Semenova N. V. , Ryazanceva N. V. , Legkiy A. V. , Anisimova I. P. , Lopatin Yu. M.
Published: December 2018

The aim of this study was to evaluate the effect of the thiazide-like diuretic indapamid retard on cardiovascular remodeling processes in patients with arterial hypertension. The study included 20 previously untreated patients (mean age 51,7 ± 2,7 years) with Stages I - П arterial hypertension and a disease history of 2 to 6 years. The duration of indapamid retard therapy was 2 to 6 months. In patients with arterial hypertension, indapamid retard therapy leads to a decrease in left ventricular myocardial weight and to a larger number of more patients with arterial hypertension with the normal geometry of the left ventricle. There was a significant decrease in the rale of pulse wave primarily in the arteries of elastic type. By having a high antihypertensive efficacy, excellent tolerance, metabolic neutrality, indapamid retard produced a significant effect on remodeling processes of the heart, large and middle arteries in patients with arterial hypertension.
Magnesium homeostasis in patients with arterial hypertension and coronary heart disease: potentialities of correction with magnesium preparations
Authors: Levina O. I. , Makarov V. L. , Churina S. K.
Published: December 2018

Twenty-one patients with coronary heart disease, functional classes I-II angina pectoris concurrent with moderate arterial hypertension were examined. Magnesium preparations were studied for their effect on blood pressure values, ECG parameters, and exercise tolerance during a bicycle ergometric test, as well as serum lipid profile and some membranous ion-transporting systems in the red blood cells. Exogenous magnesium was not found to have any effect on blood pressure. The administration of magnesium preparations promotes a decrease in urinary excretion of magnesium and an increase in its intracellular concentration, positively affects its homeostasis and the metabolism of other elements related to the development of vascular abnormalities.
Combined pharmacotherapy for arterial hypertension in patients with type 2 diabetes mellitus
Authors: Ametov A. S. , Demidova T. Yu. , Smagina L. V.
Published: December 2018

The antihypertensive effects and tolerance of a fixed low-dose combination of the angiotensin-converting enzyme (ACE) inhibitor perindopril, 2 mg, and the diuretic indapamide, 0.025 mg (noliprel), were studied in patients with mild and moderate arterial hypertension associated with diabetes mellitus. The patients' mean age was 51.36 ± 6.11 years, Hblc was 7.86 ± 1.73 %. The antihypertensive effects were evaluated from the results of daily blood pressure monitoring following 16 weeks of therapy. It was found that noliprel exerted a multidirectional corrective effect on the daily blood pressure (BP): it provided a significant optimal BP lowering during a clay on a long-term basis; significantly normalized the pressure load index in day- and night-time; significantly diminished the baseline increased systolic and diastolic BP variabilities during a day. normalized the impaired two-phase BD profile. The efficiency of treatment was 100 %, as evidenced by clinical BP and diurnal BP profile; the achievement of targeted BP was 88 % by the end of therapy. During therapy with the agent, stable glycemia control preserved and there was no negative effect on the lipid spectrum, which permits the use of the drug in patients with arterial hypertension concurrent with metabolic disorders.
Pharmacoepidemiology of hypertensive disease in the Ulyanovsk Region
Authors: Serov V. A. , Ruzov V. L. , Gorbunov V. I. , Movchan Ye. V. , Drapova D. P.
Published: December 2018

To study the pharmacoepidemiology of hypertensive disease (HD) in the Ulyanovsk Region, as well as its conformity to the present state-of-the-art, prescriptions were analyzed by examining the outpatient medical records of hypertensive patients treated in different therapeutic-and-prophylactic institutions of Ulyanovsk and its Region. A total of 681 outpatient medical records were analyzed. The treatment of hypertensive patients in the Ulyanovsk Region is up to the present-day recommendations. The basic classes of antihypertensive agents prescribed by the physicians of the Ulyanovsk Region were angiotensin-converting enzyme inhibitors used in 84,6% of the cases, diuretics in 66.1%, calcium antagonists and ß-adrenoblockers in 28,2 and 27,8%, respectively. In the Ulyanovsk Region, the proportion of long-acting antihypertensive agents prescribed to patients with HD was found to remain low as compared with the results of the PIFAGOR study, which is mainly accounted for by economical causes.
Diagnosis of intrapsychic conflicts in young patients with arterial hypertension
Authors: Kodochigova A. I. , Kirichuk V. F. , Kucherov M. G. , Gerasimova I. K.
Published: December 2018

Patients’ responses, mainly a high anxiety, have a great impact on the development of arterial hypertension (AH) and its complications The capacities of the current projective procedure - psychogeometnc testing - to identify psychoemotional disorders in young patients with AH in relation to the severity of disease had not been studied, which was the purpose of the present study The psychogeometnc test was used to examine 138 persons, including 95 young patients with AH, who presented all three degrees of the severity of disease, and 43 control persons who were clinically healthy The patients with AH of varying severity were found to be psychologically heterogeneous in all three subgroups, there were contradictory intrapersonal trends that might lead to the formation of an intrapsychic conflict and increase the level of their anxiety This assumes a differential approach to psychologically correcting the psychoemotional disorders detected in young patients with AH of various severity
Arterial hypertension in patients with chronic bronchopulmonary diseases: The heart as a target organ is the focus of the problem
Authors: Barsukov A. V. , Kazantsev V. A. , Talantseva M. S. , Nikolayev A. V. , Kurganova T. A.
Published: December 2018

Fifty-seven patients with grade 1 essential hypertension concurrent with chronic obstructive bronchitis or bronchial asthma were examined. They were found to have characteristics of the daily blood pressure profile, such as a high load due to pressure and its inadequate nocturnal lowering. The concentric type of left ventricular hypertrophy (LVH) is typical of the vast majority of persons of this category. The patients with a high LVH concentricity have more significant imbalance of autonomic cardiac rhythm regulation with the preponderance of myocardial sympathetic impact while those with low LVH concentricity showed higher aldosterone secretion.
Vasoactive factors in the preeclampsia pathogenesis
Authors: Reznic V. ..
Published: December 2018

Preeclampsia-eclampsia is still one oi the leading causes of maternal and fetal morbidity and mortality. Despite active research for many years, the etiology of this disorder exclusive to human pregnancy is enigma. Recent evidence suggests there may be several underlying causes or predispositions leading to the signs of hypertension, proteinuria and edema, findings that allow us to make ithe diagnosis of the «syndrome» of preeclampsia. Despite improved prenatal care, severe preeclampsia and eclampsia still occur. Although understanding of the pal pathophysiology of there disordes has improved, treatment has not changed significantly in over 30 years. Although postponement of delivery in selected women with severe preeclampsia improves fetal outcome to a degree, this is not done without risk to the mot her. The search for the underlying cause of this disorder and for a clinical marker to predict those women who will develop preeclampsia-eclampsia is ongoing, with its prevention the ultimate goal. Moreover, prospective longitudinal studies are needed to better assess the role of circulating angiogenic factors for the identification women at high risk of preeclampsia and the early diagnosis of disease.
Safety, effect anti tolerance of metoprolol in the treatment of elderly and old patients of cardiological profile
Authors: Vologdina I. ..
Published: December 2018

76 elderly patients with cardiac heart disease (CHD) (31 male and 45 female) were included in the study. Mean age was 81.6 ± 3.4 (from 76 to 89) years. All investigated patients had stable angina pectoris (I-III class). The duration of disease was 8-15 years. The patients were hypertensive (mean arterial pressure 164.5 ± 5.8 / 100 ± 4.3 mm Hg) and had clinical symptoms of heart failure (II class by NYHA). The mental status was evaluated by variety specific tests. The quality of life was assessed by using questionnaire scale SF-36 Health Stains Survey. All subjects were treated by nitrates. ACE-inhibitors and diuretics. Patienis were divided into 2 groups, clinical data and demographies signs of witch, were comparable. 29 patients (1 group) received Metocard 25-100 mg per day. 27 patients were included in control group. Patients of 1 group demonstrated more pronounced increase of distance in test with 6-minutes walking. The depression level after treatment period was significantly reduced in patients of 1 group compare with control group and it's precede level (Camilton scale). Evaluation of quality of life following treatment period shewed statistically significant improvement of number indexes of scale SF-36 Health Status Survey.
Does hypertension during pregnancy contribute to female metabolic syndrome?
Authors: Tkacheva O. N. , Razgulaeva N. F. , Guseva K. Y. , Samsonenko N. S. , Mishina I. E. , Barabashkina A. V. , Maksimenko L. P. , Mokeeva I. P.
Published: December 2018

The aim of the study was to assess metabolic abnormalities in women with different patterns of hypertension during pregnancy in a prospective long-term observational study. 38 females were followed for 10 years after pregnancy. 16 females with normal pregnancy served as a control group. It is shown than hypertension during pregnancy predispose to blood pressure stabilization, target organ damage as well as metabolic disturbances and can predispose to metabolic syndrome manifestation. Maternal weight before pregnancy, and weight increase during pregnancy are predictors of future metabolic syndrome. It was shown also that enalapril 5-20 mg per day can significantly reduce blood pressure and improve metabolic glucose and lipid parameters in such women.
Pharmacoeconomics in management of hypertension and heart failure
Authors: Fillipenko N. G. , Povetkin C. V.
Published: December 2018

The review describes result of pharmacoecomic analysis of treatment of hypertension and heart failure with ACE inhibitors. It is shown that cost-effectiveness analysis can reveal economic advantages of several drugs that seem to be more expensive compared to other representatives of the same drug class.
Analysis of polymorphisms of renin-angiotensin system and bradykinin receptor genes in children and adolescents with primary arterial hypertension
Authors: Obraztsova G. I. , Glotov A. S. , Stepanova T. V. , Ivashchenko T. E. , Kovalev Y. R.
Published: December 2018

We inspected 179 children and adolescents aged 9-17 years with primary arterial hypertension (AH) and 158 schoolchildren aged 7-17 years. All the hypertensive children underwent 24 hour ABPM. Family history of all the children was studied in particular of cardiovascular diseases. The 19-83G/A polymorphism of renin gene (REN), the M235T polymorphism of the angiotensinogen gene (AGT), the I/D polymorphism of angiotensin converting gene (ACE), the Al 166C polymorphism of angiotensin II type 1 receptor (AGTR1) gene, the C3123A polymorphism of angiotensin II type 2 receptor gene (AGTR2), I/D and T/С polymorphisms of the bradykinin receptor 2 gene (BKR2), were analyzed. We found out the significant increase of A allele and genotype AA of 19-83G/A polymorphism of gene REN frequencies of the children with stable AH in comparison with control group. In the group of children with stable hypertension - in comparison with the group of children, who has white coat hypertension and labile AH, we found out statistically significant prevalence of T allele the M235T polymorphism of the gene AGT. Distribution of I/D polymorphisms frequencies for ACE and BKR genes was similar in children and adolescents with primary AH compared to control group. The children with AH, who had relatives with coronary disease, had significant increase of A allele and genotype AA polymorphism A1166C of gene AGTR1 frequencies. We did not find out significant differences in distribution of A and С alleles of C3123A polymorphism of gene AGTR2 between the hypertensive children and control group. The males with AH had significant distribution difference of alleles polymorphism T58C gene BKR2 with allele С increase.
The properties of twenty-four-hours blood pressure profile in patients with hypertonic encephalopathy and chronic heart failure
Authors: Geraskina L. A. , Mashin V. V. , Fonjakin A. V.
Published: December 2018

The aim of this study was in evaluation of twenty-four-hours blood pressure profile parameters in patients with hypertonic encephalopathy and chronic heart failure. 113 patients with hypertonic encephalopathy (39 males, 74 females, mean age 53±13.2 years) were investigated. Chronic heart failure was confirmed in 101 patients (89.4%). There aren’t any essential discrepancies between patients with different stages of hypertonic encephalopathy . Chronic heart failure was associated with elevation of pulse blood pressure more than 53 mm Hg and increase of «non-dipper» and «night-peaker» patients. The same changes of blood pressure profile were related with heart failure progression and intensity of neurological disturbances.
Efficacy and tolerability of rilmenidine and its combination with amlodipine in different ages (according to ALTAIR study)
Authors: Shalyakhto E. V. , Conrady A. O.
Published: December 2018

The aim of the study was to evaluate efficacy and tolerance of rilmenidine and its combination with amlodipine in different age groups from ALTAIR study population. Rilmenidine therapy resulted insignificant reduction of blood pressure in all ages as well as had good tolerability. In conclusion, analysis of ALTAIR data indicates that Imidazoline agonists, in particular rilmenidine, can be administrated for hypertension treatment in patients of all ages.
New perspectives of improvement of compliance - results of open study of adherence of patients to treatment with fixed in one blister combinations of enalapril and indapamide
Authors: Sviryaev Yu. V. , Zvartau N. E. , Rotari O. P. , Emelyanov I. V. , Avdonina N. G. , Conrady A. O.
Published: December 2018

The aim of the study was to evaluate the adherence of patients to treatment with new fixed in one blister combinations of enalapril and indapamide. 115 patients participated in the study. In conclusion, analysis revealed high efficacy of studied combinations, which can be partly explained by high compliance of patients.
Acetazolamide in the treatment of sleep apnea m adults and childi en
Authors: Bikova O. V. , Kusenkova L. M. , Maslova O. I. , Boyko A. N.
Published: December 2018

Obstructive sleep apnea syndrome (OSA) is life-threatening condition in adults and children. Prevalence of OSA in adult and pediatric population is not well-established as not all patients have clear clinical picture. In Britain prevalence of OSA syndrome is comparable to asthma disease. Acetazolamide can cause metabolic acidosis, which can stimulate pulmonary ventilation and proposed to be effective in treatment of sleep breathing disturbances. Acetazolamide is widely used to therapeutic treatment of central OSA in adults and children. In adults administration of this drug can have problems of tolerance if administrated chronically. Alternatively, in children, OSA is usually transitory condition is early childhood what allow to treat it with acetazolamide effectively.
The calculation of spontaneous arterial barorexlex sensitivity via joint analysis of arterial blood pressure and heart ratebeat-to-beat fluctuation
Authors: Bogachev M. I. , Mamontov O. V. , Conrady A. O. , Ulyanitskiy Y. D.
Published: December 2018

Autonomic dysfunction is associated with negative prognosis in cardiovascular patiens and several other pathologies. Arterial baroreflex sensitivity is an important marker of autonomic regulation. Present work is devoted to the new approach to spontaneous baroreflex estimation, which permit to improve quality of the continious blood pressure and ECG monitoring analysis. The method of combined estimation of probability density of blood pressure and R-R intervals is proposed in this article, which improves efficacy of use of date records due to the increased number of included beats in calculation. This method is appeared to have better reproducibility and, probably, sensitivity for autonomic dysfunction diagnosis compared to traditional approaches. Moreover, offered method allow to measure additional arterial barorexlex characteristics. Thus, the calculation of barorexlex sensitivity combined probability density allows to wide the sphere of spontaneous baroreflex estimation, including changeable conditions.
Remodeling of cardiovascular system and function of parathyroid glands in patients with arterial
hypertension
Authors: Iskenderov B. G. , Burmistrova L. F. , Berenshtein N. V. , Lokhina T. V. , Abramova G. N.
Published: December 2018

Features of structural and functional remodeling of the left ventricular and brachial artery and parathyroid hormone blood levels are studied in 95 patients with arterial hypertension. It was shown that increased parathyroid hormone blood levels correlate with increased frequency and evidence of remodeling of left ventricular and brachial artery, also significant decrease in diastolic function and endothelium-dependent vasodilatation. 21.6 % of hypertensive patients have asymptomic of parathyroid hormone hyper secretion. Pathological type of circadian blood pressure profile was observed in these patients.
Comparison of efficacy of fixed combinations of verapamil SR+ trandolapril and captopril + HCTZ in high risk hypertensive patients
Authors: Nedogoda S. V. , Chalabi Т. A. , Tsoma V. V. , Brel U. A.
Published: December 2018

The blinded randomized study the clinical effecacy and tolerability during 6 month therapy with one of two fixed combinations Tarka (verapamil SR+trandolapril) and Capozide (captopril+HCTZ) were compared patients (20 patients at every group) with arterial hypertension who did not achiev target blood pressure on monotherapy. Tarka was more effective decreased of left ventricular hypertrophy and improved vascular elasticity. Tarka also had better T/P coefficient. Tarka improved glucose level, Capozide worsen potassium levels.
Cognitive functions and neurodinamics status in hypertensive patients of young and miaal age
Authors: Smakotina S. A. , Trubnicova O. A. , Ananko Yu. V. , Zykov M. V. , Plehanova L. P. , Barbarash O. L.
Published: December 2018

41 arterial hypertensive (AH) men of 38-59 years old without adequate previous research. Cognitive function (simple and complex visual-motor reactions) was evaluated with computer Status PF Program. Cognitive disturbances (CD) in AH patient of young and mature age revealed. At the same time the level of AH and its duration are connected with CD nature by U-form dependence. Maximal CD develops in patients with AH duration less then 1 and more than 10 years. More optimal cognitive function parameters are revealed in 40-50 years old patients and 5-10 years AH duration. The absence of adequate night arterial pressure decrease is associated with CD, too.
Combination antihypertensive therapy with amlodipine and rilmenidine (according to ALTAIR Study data)
Authors: Shlyakhto E. V. , Konradi A. O.
Published: December 2018

The manuscript addresses subanalysis of ALTAIR Study population being on combination therapy of rilmenidine and amlodipine. The efficacy and safety of such combination is shown. Possible decrease in side effects caused by rational drug combination is discussed, as well as positive metabolic changes and body mass reduction is documented in this subgroup. This allows to recommend such combination of antihypertensive drugs for patients with concomitant pathology including so-called metabolic syndrome.
Application of an angiotensin)converting enzyme inhibitor zofenopril in patients with paroxismal form of atrial fibrillation
Authors: Tatarskyi B. A.
Published: December 2018

In article the received data of pilot research of application of an angiotensin-converting enzyme inhibitor zofenopril in patients with paroxismal form of atrial fibrillation without structural diseases of heart are submitted. It is shown, that prescription of zofenopril in this category of patients is an effective and safe method of treatment. Probable mechanisms of positive influence of a preparation on current of an arrhythmia are discussed.
The captopril and eprosartan influence on hemodynamic parameters in rats with renovascular hypertension
Authors: Gavrikov K. E. , Rubanova N. S. , Chrustaleva R. S. , Tsyrlin V. A.
Published: December 2018

The aim of this investigation is the comparison of captopril and eprosartane influence on the level blood pressure, its variability and baroreceptor reflex in normal rats and rats with vasorenal hypertension. It was shown that hypertensive rats had higher level of blood pressure, heart rate and its variability than normotensive rats. There was no relationship between arterial blood pressure and its variability in normal as well as hypertensive rats. Captopril decreased blood pressure and had no effect on variability of blood pressure. In rats with renovascular hypertension an increased baroreflex and decreased variability of heart rate was note. Eprosartan, as well as captopril, decreased blood pressure, but increased variability of blood pressure in rats with hypertension.
Efficacy and safety of metoprolol-retard in elderly hypertensives
Authors: Turina T. , Grotova A. , Krilova L. , Bukhenski I.
Published: December 2018

Resume Efficacy and tolerability of metoproplol-retard was studied in elderly hypertensive patients compared to standard metoprolol tartrat. The antihypertensive effect, antiagnginal effect and changes of symptoms of heart failure were studied as well as patients compliance and orthostatic intolerance.
Subclinical inflammation and redox
status in untreated patients with type 2 diabetes
mellitus
Authors: Kobalava Z. , Villevalde S. V. , Isikova H. V. , Gudgalis N.
Published: December 2018

Inflammation and oxidative stress play an important role in diabetes type 2 development and its complications. Inflammation is believed to be a connecting point between metabolic changes and cardiovascular diseases. The aim of the study was to investigate inflammation and oxidation as well as adiponectin level in untreated diabetic patients. In 158 patients the level of leucocytes, TNF-alfa, interleukins-1в, 4, and 6 were measured together with adiponectin, maalonic dialdegid, and sulfhydrated radicals. Male gender, dyslipidemia, metabolic syndrome were associated with increased level of uric acid and low level of adiponectin. Lipid and glucose metabolism abnormalities were related to oxidation activity without any association with antioxidation response. Adiponectin level was not related to inflammatory markers. Regression analysis revealed that inflammation markers and oxidative stress are not related to gender, age, smoking status and blood pressure but are determined by lipid and glucose metabolism.
Polymorphisms of renin-angiotensin system genes and endothelial dysfunction in young males with a history of myocardial infarction
Authors: Bekovitch O. , Bazhenova E. , Vakhrameeva N. , Volkova E. V. , Larionova V. , Shlyakhto E. V.
Published: December 2018

We studied relationship between renin-angiotensin system (RAS) gene polymorphisms and parameters of endothelial function in males with history of myocardial infarction in young age. We found endothelial dysfunction in these patients. There were no correlations between certain polymorphic genes and risk of myocardial infarction. At the same time, insertion/deletion polymorphism of the angiotensin-converting enzyme gene was associated with more prominent endothelial dysfunction in males with history of myocardial infarction in young age. These data may confirm influence of RAS gene polymorphism on the endothelial dysfunction.
Homocysteinemia as a risk factor of diabetic nephropathy in children and adolescents
Authors: Shutskaya Zh. V.
Published: December 2018

This article summarizes data on homocysteinemia and its influence on vascular pathologic changes in patients with different diseases including diabetes type 1 and type 2. The role of homocystein as an independent risk factor for diabetic nephropathy in children and adolescents is discussed. The problem of homocysteinemia treatment is reviewed.
Cellular and humoral apoptosis markers in acute coronary syndrome combined with essential hypertension
Authors: Vasina L. V.
Published: December 2018

The aim of this work was to examine the contents of annexin A5, sApo-1/Fas and sBcl-2 and the number of circulating mononuclear cells in apoptosis in order to clarify their role in the pathogenesis of acute coronary syndrome (ACS) combined with arterial hypertension (AH). We examined 83 patients with ACS (47 patients with unstable angina and 36 with myocardial infarction) and 14 healthy individuals. AH has been identified in 15 patients with unstable angina and in 17 with myocardial infarction. The number of viable mononuclear cells was significantly decreased and the number of mononuclear cells at the early stages of apoptosis (annexin A5-positive) was significantly increased as compared to control group in patients with the ACS, especially if combined with AH. At the same time there was a significant increase of sBcl-2 and sApo-1/Fas and annexin A5 in blood of the patients with myocardial infarction compared to patients with unstable angina, especially if combined with AH. The association between the level of sAro-1/Fas, annexin A5 and the number of circulating mononuclear cells at the early stages of apoptosis was shown in the study. Thus, in ACS, especially if combined with AH, enhanced cell apoptosis resulting from hemodynamic abnormal changes leads to activation of antiapoptotic mechanisms aimed at the decrease of the thrombophilia severity by reducing thrombogenic features of endotheliocytes subjected to apoptosis.
Metoprolol is a drug of choice for a patient with cardiovascular pathology
Authors: Lyamina N. P. , Lyamina S. V.
Published: December 2018

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