bluuebunny/crossref_metadata_2025 huggingface dataset:
KMT2D Regulates the NCOA6/THRB Signal Axis through Epigenetic Modification to Promote the Migration and Invasion of Papillary Thyroid Cancer
Authors: Wang Rui , He Yibo , Wang Yi , Xie Shangnao
Published: January 2023

Background: The histone lysine methyltransferase Histone-lysine N-methytransferase 2D (KMT2D) is a common mutated gene in a variety of cancers, including papillary thyroid cancer (PTC). However, the mechanism of KMT2D on the progression of PTC remains unclear. Methods: In this study, quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to evaluate KMT2D expression between human normal cell (Nthy-ori 3-1) and PTC cells (TPC1, IHH-4 and BCPAP). Proliferation, migration and invasion of TPC1, IHH-4 and BCPAP were assessed by Cell Counting Kit-8 (CCK-8), Wound-healing assay and Transwell assay. The mechanism of KMT2D on thyroid papillary cancer was explored with Chromatin immunoprecipitation assay (ChIP), qRT-PCR and Western blotting. Results: The expression of KMT2D in PTC cells was significantly increased. Downregulation of KMT2D significantly decreased the proliferation, migration and invasion of PTC cells, which was correlated with decreased expression levels of H3K4me2, H3K9me2, NCOA6 and THRB. Meanwhile, ChIP assay demonstrated that KMT2D was associated with NCOA6. Conclusions: Study have shown that the downregulation of KMT2D reduces proliferation, migration and invasion of thyroid papillary carcinoma cells through epigenetic modification of NCOA6/THRB signal axis. These results provide a new insight into the role of KMT2D in migration and invasion of PTC.
iTRAQ and PRM-Based Comparative Proteomic Profiling of the Hippocampus in Rat Models of Epilepsy
Authors: Zhao Congcong , Zheng Zhe , Zhu Shisheng , Zhang Li , Zhang Peng , Xiong Hongli , Li Yongguo , Zhu Ying , Zhao Minzhu , Li Jianbo
Published: January 2023

Background: Epilepsy is a disease caused by paroxysmal abnormal supersynchronous electrical activity of brain neurons, and it is also one of the most common illnesses in neurology. Among the causes, hippocampal sclerosis may be one of the main causes of temporal lobe epilepsy. However, the pathogenesis of hippocampal sclerosis in epilepsy remains unclear. Methods: We established an epilepsy model by intraperitoneal injection of pentetrazol (PTZ) into Sprague-Dawley rats, and applied isobaric tags for relative and absolute quantitation (iTRAQ) technology to identify differentially expressed proteins (DEPs) in the hippocampus. We quantified a total of 3782 proteins. DEPs were defined as proteins with a fold change >1.2 (or <0.83) and a Q value (p-adjusted) <0.05. Results: Comparing the epilepsy group and the control group, we identified 170 DEPs, comprising 109 upregulated and 61 downregulated proteins. According to bioinformatics analysis, the DEPs were primarily involved in long-term potentiation, the calcium signalling pathway, aldosterone synthesis and secretion, carbon metabolism, and dopaminergic synapses. Four of these proteins were validated using parallel reaction monitoring (PRM), including Glud1, Atp1a2, Prkcg and Arpc3. Conclusions: Our research results may provide further insight into the molecular pathology of hippocampal injury in epilepsy.
Contemplating on the Nature of Selfhood in DoC Patients: Neurophenomenological Perspective
Authors: Fingelkurts Andrew A. , Fingelkurts Alexander A
Published: January 2023

Medical well-regarded policy recommendations for patients with disorders of consciousness (DoC) are almost exclusively relied on behavioural examination and evaluation of higher-order cognition, and largely disregard the patients’ self. This is so because practically establishing the presence of self-awareness or Selfhood is even more challenging than evaluating the presence of consciousness. At the same time, establishing the potential (actual physical possibility) of Selfhood in DoC patients is crucialy important from clinical, ethical, and moral standpoints because Selfhood is the most central and private evidence of being an independent and free agent that unites intention, embodiment, executive functions, attention, general intelligence, emotions and other components within the intra-subjective frame (first-person givenness). The importance of Selfhood is supported further by the observation that rebooting of self-awareness is the first step to recovery after brain damage. It seems that complex experiential Selfhood can be plausibly conceptualized within the Operational Architectonics (OA) of brain-mind functioning and reliably measured by quantitative electroencephalogram (qEEG) operational synchrony.
Effects of the Left M1 iTBS on Brain Semantic Network Plasticity in Patients with Post-Stroke Aphasia: A Preliminary Study
Authors: Yang Qing , Xu Shuo , Chen Mengye , Deng Panmo , Zhuang Ren , Sun Zengchun , Li Chong , Yan Zhijie , Zhang Yongli , Jia Jie
Published: January 2023

Background: The left primary motor area (M1) stimulation has recently been revealed to promote post-stroke aphasia (PSA) recovery, of which a plausible mechanism might be the semantic and/or the mirror neuron system reorganization, but the direct evidence is still scarce. The aim of this study was to explore the functional connectivity (FC) alterations induced by the left M1 intermittent theta burst stimulation (iTBS), a new transcranial magnetic stimulation paradigm, in the semantic and mirror neuron systems of PSA patients. Methods: Sixteen PSA patients accepted the left M1 iTBS and underwent a resting-state functional magnetic resonance image (fMRI) scanning before and immediately after the first session of iTBS, of which six underwent another fMRI scanning after twenty sessions of iTBS. Three brain networks covering the semantic and the mirror neuron systems were constructed using the fMRI data, and the FC alterations following one-session iTBS were investigated in the networks. Additional seed-based FC analyses were conducted to explore the longitudinal FC patterns changes during the course of multi-session iTBS. The Aphasia quotient of the Chinese version of the western aphasia battery (WAB-AQ) was used to assess the severity of the language impairments of the participants. The relationship between the longitudinal WAB-AQ and network FC changes was analyzed by Spearman’s correlation coefficients in the multi-session iTBS sub-group. Results: Decreased FCs were noted in the bilateral semantic rather than in the mirror neuron networks following one-session of iTBS (p < 0.05, network based statistical corrected). Longitudinal seed-based FC analyses revealed changing FC ranges along the multi-session iTBS course, extending beyond the semantic networks. No significant relationship was found between the longitudinal WAB-AQ and network FC changes in the multi-session iTBS sub-group. Conclusions: The left M1 iTBS might induce FC changes in the semantic system of PSA patients. Clinical Trial Registration: This research was registered on the Chinese Clinical Trial Registry website (http://www.chictr.org.cn/index.aspx), and the registration number is ChiCTR2100041936.
Experiment ended
Authors: Evans Isabelle
Published: January 2023

The Cost of Science: An Ethical Dilemma
Experiment ended
Authors: Zhang Wei
Published: January 2023

The Cost of Science and Ethical Considerations
Insufficient Funding for Scientific Research in Vietnam
Authors: Han YouAI
Published: January 2023

Insufficient Funding for Scientific Research in Vietnam
PERKEMBANGAN ANTROPOLOGI HUKUM DI INDONESIA
Authors: Novita
Published: January 2023

Antropologi hukum merupakan salah bidang ilmu hukum yang masih sangat jarang diketahui oleh masyarakat luas. Orang lebih mengenal antropologi sebagai bidang ilmu yang dekat dengan peristiwa sejarah dan budaya dan karena itu tidak mungkin memiliki kaitan dengan ilmu hukum. Namun inilah hukum, bidang ilmu yang sangat luas dan mencakup hampir seluruh aspek kehidupan manusia.
Q’kay: a manager for the quality assessment of large neuroimaging studies
Authors: Savary Elodie , Provins Céline , Sanchez Thomas , Esteban Oscar
Published: January 2023

Despite substantial efforts toward improving the tools to carry out the visual assessment of quality, as well as automation, the quality control (QC) of imaging data remains an onerous, yet critical step of analysis workflows, especially within large-scale studies. Indeed, the reliability and reproducibility of results can be improved by implementing QC checkpoints throughout the workflow (Niso et al. 2022, Provins et al. 2023). Here, we introduce Q’kay, a web service to deploy rigorous QC protocols on large datasets leveraging the individual reports generated by tools like MRIQC (Esteban et al., 2017) and fMRIPrep (Esteban et al., 2019).
Bearded Pig (Sus barbatus)
Authors: Kurz David , Malim Peter , Goossens Benoit
Published: January 2023

This chapter is a postprint that provides an overview of the bearded pig (Sus barbatus) in Sabah, including background, taxonomy, natural history, cultural significance, distribution, and conservation. The chapter also includes a status update of the impact of African Swine Fever (ASF) on local collapse of bearded pig populations across Sabah in 2020 and 2021. This chapter was published by WWF-Malaysia in the Wildlife Atlas of Sabah: maps and conservation, edited by Dr. Glyn Davies.
Liputan EBC Expo 2022
Authors: Nabila Noor Anisa
Published: January 2023

Pemeran usaha merupakan strategi pemasaran yang paling efektif untuk dilakukan dan di ikuti, khusus nya bagi pelaku bisnis UMKM, dimana pameran usaha dapat mempromosikan dan memperkenalkan produk, serta dapat meningkatkan penjualan.
The Benefits of Incorporating Insects into Human Diets Exploring the Cost and Ethics of Science
Authors: Han YouAI
Published: January 2023

The Benefits of Incorporating Insects into Human Diets Exploring the Cost and Ethics of Science
Cara Menghadapi Resesi dalam Menjalankan Bisnis
Authors: Angelina Priskila
Published: January 2023

Akhir-akhir ini, resesi 2023 menjadi perbincangan yang ramai dimana resesi bisa terjadidi negara manapun termasuk negara Indonesia. Sebelumnya, para ekonom dunia sudahmemprediksi bahwa resesi akan terjadi besar-besaran pada tahun 2023 mendatang. BankDunia mengetahui penyebab terjadinya resesi 2023 yang dimana berasal dari bank sentral diseluruh dunia secara bersamaan yang menaikan suku bunga dan memiliki pemicu lainnyaseperti pandemic Covid-19 melanda dan konflik Rusia-Ukraina. Hal tersebut yang membuatberbagai negara kesulitan dalam rantai pasokan komoditas yang diperlukan.
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Authors: sumardi vezy harni
Published: January 2023

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FILSAFAT HUKUM MENJADI SUMBER DASAR ILMU HUKUM
Authors: FAKHRIZAL JOHNNY
Published: January 2023

1. Epistemologi dalam Filsafat, Epistemologi berasal dari kata Yunani, yaitu epistememe yang artinya pengetahuan dan logos adalah perkataan, pikiran, ilmu. Epistemologi bermaksud secara kritis mengkaji pengandaian-pengandaian dan syarat-syarat logis yang mendasari dimungkinkannya pengetahuan serta mencoba memberi pertanggungjawaban rasional terhadap klaim kebenaran dan objektivitasnya. 2. Rasionalisme adalah faham filsafat yang menyatakan bahwa akal (reason) adalah alat terpenting untuk memperoleh pengetahuan dan menetes pengetahuan. Jika empirisme mengatakan bahwa pengetahuan diperoleh dengan alam mengalami objek empiris, maka rasionalisme mengajarkan bahwa pengetahuan diperoleh dengan dengan cara berpikir. Alat dalam berpikir itu adalah kaidah-kaidah logis atau aturan-aturan logika.
Teacher Collaboration and Professional Learning: Examining Professional Development During a National Education Reform
Authors: Richter Eric , Fütterer Tim , Meyer André , Eisenkraft Arthur , Fischer Christian
Published: January 2023

Teacher collaboration is an important feature of job satisfaction and self-efficacy of teachers. Moreover, the collaboration of teachers is important for adopting professional changes, as professional development (PD) activities that include opportunities for collaboration have been shown to support teachers in improving classroom practice, leading to higher student performance. Situated in the context of the Advanced Placement (AP) reform in the United States, we investigated the perceived importance of opportunities to collaborate with colleagues as a rationale to participate in PD (N = 3,725 teachers). Using descriptive and regression analyses, we found that the opportunity to collaborate with colleagues was a primary rationale why teachers selected PD activities. While this rationale is only slightly related to school and teacher characteristics, we found it to be particularly related to PD characteristics. Specifically, opportunities to collaborate with colleagues were important to teachers in selecting informal face-to-face PD activities. We conclude that collaborative structures benefit all forms of teacher professional development.
FILSAFAT HUKUM MENEGAKAN ALIRAN DASAR ILMU HUKUM
Authors: Gusmawati Ila
Published: January 2023

Dari uraian tersebut diatas kami sebagai penulis dapat menarik kesimpulan yakni bahwa di dalam tiap-tipa aliran itu terdapat sesuatu yang dapat dibenarkan serta dapat diambil manfaatnya serta aliran sistem hukum terbukalah yang meletakkan persoalan undang-undang, hakim, dan hukum ini secara lebih tepat sebagaiman yang telah dijelakan oleh Prof. Achmad sanusi diatas.Berdasarkan pandangan ini, maka hukum perdata merupakan bagian dari subsistem dari hukum nasional oleh karena itu asas hukum perdata harus sesuai dan seirama denagn asas hukum nasional. ilsafat hukum adalah cabang filsafat, yaitu filsafat tingkah laku atau etika,yang mempelajari hakikat hukum. Dengan perkataan lain, filsafat hukum adalah ilmu yang mempelajari hukum secara filosofis. Jadi objek filsafat hukum adalah hukum, dan objek tersebut dikaji secara mendalam sampai kepada inti atau dasarnya, yang disebut hakikat.Dalam pemikiran filsafat hukum yang terus berkembang sepanjang zaman, menyebabkan keragaman pola dan ukuran nilai dan idelitas dalam hubungannya dengan normativitas dan faktisitas dari dalam dunia hukum, dan terutama apabila dihubungkan dengan naluri manusia untuk mencari jalan keluar dari kesulitan dan permasalahan dalam kehidupannya, akan melahirkan berbagai aliran dalam filsafat hukum. Secara urut aliran-aliran hukum tersebut menunjukan sebuah dealegtika. Dialegtika tersebut muncul disamping karena unsur kedinamikaan manusia juga karena hukum sendiri secara teoritis dapat ditinjau beberapa konsep/perspektif hukum, sehingga memunculka beragam pemikiran,karena memang berbeda sudut pandangnya.
The applicability of G-BASE stream sediment geochemistry as a combined geological mapping, and prospective exploration tool for As-Co-Cu-Ni mineralisation across Cumbria, UK.
Authors: Eskdale Adam , Johnson Sean , Gough Amy
Published: January 2023

Stream sediment geochemistry is a useful tool to analyse the geochemistry of the local geology within the source catchment area. This has significant applicability within the field of mineral exploration where understanding regional lithological geochemistry is needed, facilitating the identification of critical metal deposits. Successful identification of these deposits is essential to help tackle the deficit of these metals supply chains, especially for cobalt. This is in order to meet future carbon-neutral technological demand as part of global initiatives towards a more environmentally sustainable society. We make use of the UK Geochemical Baseline Survey of the Environment (G-BASE) dataset to demonstrate that stream sediment geochemical data has the potential to be used as a useful tool for isolating potential Energy Critical Elements (ECEs) in host rocks across the UK Lake District. We reduced the dimensionality of the G-BASE stream sediment data, creating geochemical maps that identify a combination of volcanic, sedimentary, and plutonic lithologies lining up geological boundaries from established 50k scale geological maps of the area. This was conducted through a combined statistical and mapping approach within QGIS and ioGAS. Furthermore, we identified average ore metal concentrations (Ag, As, Bi, Co, Cu, Mo, Ni, Sn, Zn) for the Skiddaw Group and the Borrowdale Volcanic Group, two established host groups for As-Co-Cu-Ni mineralisation. Average concentrations of Co in the Skiddaw have been modelled to be 63.26 ppm, and in the Borrowdale volcanics to be 26.86 ppm. These values, combined with As, Cu, and Ni modelled concentrations, and other available exploration-related data (structural maps, underlying batholith topography, mining history etc.) have allowed us to identify 10 prospective areas of interest for possible As-Co-Cu-Ni mineralisation across these two lithological groups. This workflow has strong applicability within critical metal exploration in other, more prospective regions across the globe.
An 8-week Compassion and Mindfulness-based Exposure Therapy Program effectively improves Posttraumatic Stress Symptoms
Authors: Kummar Auretta Sonia , Correia Helen , Tan Jane , Fujiyama Hakuei
Published: January 2023

The persistence of posttraumatic stress symptoms (PTSS) can be debilitating. However, many people experiencing such symptoms may not qualify for, or may not seek, treatment. Potentially contributing to ongoing residual symptoms of PTSS is emotion dysregulation. Meanwhile, the research area of mindfulness and compassion has grown to imply emotion regulation as one of its underlying mechanisms, yet, its efficacy on emotion regulation in PTSS cohort is unknown. Here, we investigated the effectiveness of an 8-week Compassion- oriented and Mindfulness-based Exposure Therapy (CoMET) for individuals with PTSS using a waitlist control design. A total of 28 individuals (27 females, age range = 18-39 years) participated in the study (17 CoMET; 11 control). Following CoMET, participants reported significant decreases in PTSS severity (from clinical to non-clinical levels), emotion dysregulation, and experiential avoidance, as well as significant increases in mindfulness, self-compassion, and quality of life. Enhanced emotion regulation also mediated the relationship between increases in mindfulness and self-compassion with decreases in PTSS severity, while the waitlist control showed no changes, except for significant increases in difficulties with emotion regulation. Electroencephalogram-based brain network connectivity analysis revealed an increase in alpha-band connectivity following CoMET in a network that includes the amygdala, suggesting that CoMET successfully induced changes in functional connectivity between brain regions that play a crucial role in emotion regulation. In sum, the current study demonstrated promising intervention outcomes of CoMET in effectively alleviating the symptoms of PTSS via enhanced emotion regulation.
The Exceptions and the Rules in global musical diversity
Authors: Passmore Sam , Savage Patrick E.
Published: January 2023

Global music diversity is a popular topic for both scientific and humanities researchers, but often for different reasons. Scientific research typically focuses on the generalities through measurement and statistics, while humanists typically emphasize exceptions using qualitative approaches. But these two approaches need not be mutually exclusive. By using a quantitative approach to identify musical outliers, and a qualitative discussion of the most unusual songs, we can tie together scientific, and humanities approaches to unite knowledge on musical diversity. Objectively defining unusual music is a delicate task, having historically been subject to Eurocentric approaches. Using the Global Jukebox, a dataset containing almost 6,000 songs from over 1,000 societies coded on 37 “Cantometric'' variables of musical style, we designate the unusualness of a song as the frequency of its coded variables relative to their regional frequency. Using quantitative metrics to identify outliers in musical diversity, we present a qualitative discussion of some of the most unusual individual songs (from a Panpipe ensemble from Kursk, Russia), and a comparison of unusual repertoires from Malay, Kel Aïr, and Moroccan Berber musical cultures. We also ask whether unusual music is the result of unusual social organisation, cultural isolation, or as a marker of inter-societal pressures. There is weak evidence that the unusualness of music is predicted by kinship organisation and cultural isolation, but these predictors are heavily outweighed by finding that unusual songs are best predicted by knowing the society they come from - evidence that quantitatively supports the existence of musical style.
Predicting and Preventing Gun Violence: An Experimental Evaluation of READI Chicago
Authors: Bhatt Monica , Heller Sara , Kapustin Max , Bertrand Marianne , Blattman Christopher
Published: January 2023

Gun violence is the most pressing public safety problem in American cities. We report results from a randomized controlled trial (N = 2, 456) of a community-researcher partnership called the Rapid Employment and Development Initiative (READI) Chicago. The program offered an 18-month job alongside cognitive behavioral therapy and other social support. Both algorithmic and human referral methods identified men with strikingly high scope for gun violence reduction: for every 100 people in the control group, there were 11 shooting and homicide victimizations during the 20-month outcome period. Fifty-five percent of the treatment group started programming, comparable to take-up rates in programs for people facing far lower mortality risk. After 20 months, there is no statistically significant change in an index combining three measures of serious violence, the study’s primary outcome. Yet there are signs that this program model has promise. One of the three measures, shooting and homicide arrests, declines 65 percent (p = 0.13 after multiple testing adjustment). Because shootings are so costly, READI generates estimated social savings between $182,000 and $916,000 per participant (p = 0.03), implying a benefit-cost ratio between 4:1 and 18:1. Moreover, participants referred by outreach workers—a pre-specified subgroup—show enormous declines in both arrests and victimizations for shootings and homicides (79 and 43 percent, respectively) that remain statistically significant even after multiple testing adjustments. These declines are concentrated among outreach referrals with higher predicted risk, suggesting that human and algorithmic targeting may work better together.
The increasing association between child poverty and children in out-of-home care - an ecological longitudinal analysis of Finnish municipalities in the period 1992-2021
Authors: Hiilamo Aapo , Keski-Säntti Markus , Niemelä Mika , Ristikari Tiina
Published: January 2023

BackgroundInternational evidence indicates that child poverty increases the risk of child welfare intervention needs but Finland, paradoxically, has low child poverty rates and high child welfare intervention rates. We investigate the extent to which the rate of social assistance use in families with children, as a proxy for child poverty, can be associated with the rate of children in out-of-home care in Finnish municipalities. MethodsData on the annual rate of social assistance use and out-of-home care were drawn from national registers for 216 Finnish municipalities from 1992 to 2021. Linear regression models were utilised to investigate the extent to which the social assistance use rate explained child out-of-home care rates, both spatially and temporally, across municipalities and years while adjusting for the unemployment rate. ResultsThe rate of out-of-home care increased from some 700 to 1600 per 100 000 children over the period 1992-2021. A percentage point higher rate of the social assistance use was associated with 44-72 more children placed in out-of-home care per 100 000 children, net of the unemployment rate. This association was stronger in more recent time periods. A smaller association was observed within municipalities over time: a percentage point increase in social assistant use was linked to some 4-25 more children placed in out-of-home care per 100 000 children. ConclusionOut-of-home care is increasingly concentrated in Finnish municipalities with high rates of families receiving social assistance. Preventative child welfare interventions are therefore required in areas with higher rates of economic difficulties among families.
Personalizatsiia v otsenke effektivnosti deiatel'nosti klassnogo rukovoditelia
Authors: Nikolina Vera Viktorovna , Loshchilova Anna Aleksandrovna
Published: January 2023

On the basis of theoretical analysis, the essence and specifics of personalization, its capabilities in evaluating the effectiveness of the class teacher, key methodological approaches and theoretical provisions are revealed, the concept and typology of personal trajectories of the professional and personal development of the class teacher are presented and substantiated, the methodology for evaluating the effectiveness of the class teacher as a way to identify professional deficits, opportunities and resources for further professional development.
Programma-trenazhior rascheta nadezhnosti odnokonturnykh sistem avtomaticheskogo regulirovaniia
Authors: Sizova Nina Alekseevna , Osmakov Nikita Aleksandrovich , Elkov Sergei Anatolevich
Published: January 2023

The chapter describes the developed program has been developed that allows you to design single-loop automatic control systems, calculate their reliability, while simultaneously checking the user's knowledge in the field of design and ability to navigate in modern technical automation systems. When developing the program, modern software was used, namely «Visual Studio». While using the program, the user designs single-circuit automatic control systems according to such parameters as: temperature, pressure, level, flow. After designing each of the systems, the program allows the user to calculate its reliability. During the use of the program by the user, at each of its stages, if the user does not have enough knowledge, the program reports this, stops working and sends him to study the theoretical material. After completing the work, the user, through the program, must save to the computer an image with all the results obtained during the execution of the work, on which it will be indicated in the form of a watermark that all the work has been done correctly. The image can be saved to the path specified by the user in the «PNG» format. To run the program, you need a computer with Windows 7 or newer operating system, NET.Framework version 4.5 or newer. The program is portable, does not require installation, which allows it to be easily scaled to an audience with several computers, it is also worth noting that the program is small, for the time being, the size of the program is less than 5 MB, which allows it to be sent to students who are unable to attend classes via the Internet.
Obuchenie inoiazychnoi monologicheskoi rechi budushchikh uchitelei inostrannogo iazyka v raznourovnevykh gruppakh
Authors: Novoklinova Anna Vladimirovna , Valko Olga Vladimirovna
Published: January 2023

The authors presented an approach to teaching foreign language monolog speech to students in multi-level groups, including numerous ones. These skills acquire particular relevance within the professional teachers’ training context: later on they teach speaking skills to their ESL students. The approach is based on video lectures hosted by TED, which are used as reference texts for students to build their own monologs. The authors outlined the principles and presented the algorithm of work. The important components are listening to the lecture (exposure to example) and redoing the speaking.
Relationship between Mental Health and Quality of Life among Health Care Workers during COVID-19 Pandemic in Vietnam
Authors: D. Nguyen Chinh
Published: January 2023

Background: The COVID-19 pandemic has serious consequences around the world, especially in the healthcare system. With a crucial role in the pandemic, mental health and quality of life among health care workers (HCWs) needs to be addressed. Purposes: The study aimed to describe mental health and the health-related quality of life among HCWs and explore the relationship between mental health and quality of life among HCWs during the COVID-19 pandemic. Methods: A cross-sectional study was conducted from 6 April to 19 April 2020 at nine hospitals in Vietnam. The questionnaire included participant's characteristics, health-related quality of life (HRQoL), Patient Health Questionnaire (PHQ), and Generalized Anxiety Disorder (GAD). De-pression and anxiety were defined as PHQ scoregreater than or equal to 10 and GAD scoregreater than or equal to 8, respectively. Descriptive, bivariate, and multiple regression analyses were used to analyze the data with a significant level at p less than 0.05. Results: A total of 3,757 HCWs were enrolled in the study. Proportions of de-pression and anxiety were 4.5 Percentage and 3.1 Percentage, respectively. The overall mean score of HRQoL was 73.4 ± 14.9 (possible score range from 0 to 100). Protective factors of HRQoL consisted of physical activity, ability to pay for medication, gender, and social status, while its risk factors included suspected COVID-19 symptoms, smoking status. HRQoL was associated with depression (B(95 PercentageCI) = -8.15 (-10.76 to -5.55) and anxiety (B(95 PercentageCI) = -6.87 (-9.99 to -3.75)), p less than0.001. Conclusion: There was a relationship between mental health and the health-related quality of life among HCWs. Integration of healthy lifestyles and psychological support can help improve mental health and quality of life for HCWs during the pandemic.
To The Question of Active Sports During the Period of Menstrual Bleeding
Authors: Anatolyevich Bugaevsky Konstantin
Published: January 2023

The article presents the results of a study aimed at identifying the individual characteristics of the self-functioning and physical activity of athletes engaged in different sports, with their active sports, during menstrual bleeding. The results of anonymous questionnaire and additional interviews were studied and analyzed. The relationship between the timing of professional sports, the level of sports skills, durability and volume of physical exertion, is actively engaged in sports during menstrual bleeding. According to the results of the study, practical conclusions were made, and practical recommendations are given.
Synthesis of dibenzoylmethane-flavonoid hybrids as potential uv filters. Hybrids of chalcones
Authors: Svarc Federico
Published: January 2023

Background: It has been reported that chalcones (a family of flavonoids) have activity as UV rays absorbers. Previously we have reported that the compounds2´-hydroxy-4- methoxychalcone and 2´-hydroxy-4-methoxy dibenzoylmethane have the basic properties of UVA filters (both show their maximum absorption in the range 350-370 nm with good photostability) Objective: in this work, we describea new series of chalcone-dibenzoylmethane hybrid candidates as synthetic UV filtersand flavonoids Method: The compounds resultedfrom multi step synthesisstarting from 4-formylbenzoic acid and 2´- hydroxy acetophenone. Purification was done by recrystallization or column chromatography. Results: The compounds were obtained with good yields and characterized by spectroscopy. Conclusion: They are good candidates for UVA filters in cosmetics. Drs. Svarc and Minaberry will performthe corresponding photostability studies.
COVID-19 Risk in Patients with Substance use Disorders at Kuwait Addiction Treatment Center
Authors: Mohamed Yousri Bondok Sameh
Published: January 2023

Background: The COVID-19 pandemic is creating major issues for healthcare and broad social structures, exposing societal vulnerabilities. Patients with substance use disorder are considered at increased risk of COVID-19 and its more serious complications, however data on the impact of COVID-19 are lacking. The study aimed to describe the clinical characteristics and outcomes of COVID-19 on patients with substance use disorders seen at Kuwait addiction treatment center. Method: A cross sectional study was carried including all patients seen in outpatient department and/or admitted in the inpatient wards of Kuwait Addiction Treatment Center, diagnosed as substance use disorder with history of COVID-19 infection during the period from June 2021 to December 2021. Results: Among 660 substance use disorder patients, the mean age was 36± 10.1 years (94%) were men and (91.1%) were Kuwaiti. The main substance used were Opioid in (41.1%) of patients, stimulant in (25.5%) and synthetics in (11.2%) of patients. One or more comorbidities associated to COVID-19 risk were observed in (29 %) of patients. (9.1%) of patients got COVID-19 infection and 61.5% were vaccinated. Conclusion: In spite of the hypothetical risk for COVID-19 among patients with SUD, current study declared low prevalence of COVID -19 infection among patients with SUD.
Ileo-Ileal Intussusception Presenting as Cullen’s Sign: A Case Report
Authors: Shafi Aamir
Published: January 2023

Intussusception is defined as the telescoping of one segment of intestines into another causing intestinal obstruction. This condition although common in children is considered a rare condition in adults and is usually present secondary to a pathological lead point like a neoplasm in adults. It usually presents with non-specific complaints like abdominal pain and as such peri umbilical ecchymosis (Cullen’s sign) has not been seen as a presenting symptom of intussusception. Here we present a rare case of acute abdominal pain with contrast imaging of abdomen revealing ileo ileal intussusception. The patient had periumblical ecchymosis (Cullen s sign) on abdominal examination.
Clinical Symptoms and Risk Factors Associated with Schizophrenic Patients in Yemen
Authors: A. Al-Shamahy Hassan
Published: January 2023

Intussusception is defined as the telescoping of one segment of intestines into another causing intestinal obstruction. This condition although common in children is considered a rare condition in adults and is usually present secondary to a pathological lead point like a neoplasm in adults. It usually presents with non-specific complaints like abdominal pain and as such peri umbilical ecchymosis (Cullen’s sign) has not been seen as a presenting symptom of intussusception. Here we present a rare case of acute abdominal pain with contrast imaging of abdomen revealing ileo ileal intussusception. The patient had periumblical ecchymosis (Cullen s sign) on abdominal examination.
Determinants of Immunization Status Among 12-24 Months Old Children in Ethiopia: Using 2019 Ethiopian Mini Demographic and Health Survey Data
Authors: Animut Metkie Kassahun
Published: January 2023

Background: Vaccination is a global success story, one of the most effective and successful health interventions for health and development, saving the lives of millions of children every year. In 2018, nearly 870,000 Ethiopian children did not receive the life-saving measles, diphtheria, and tetanus vaccines. This study aimed to determine what factors influence children's immunization status in Ethiopia. Methods: Immunization status was examined in a sample of 1843 children aged 12-24 months using data from the 2019 Ethiopian Mini Demographic and Health Survey 2019. Percentages were used to show the prevalence of immunization status among children. The marginal likelihood effect was used to determine the impact of each category of the explanatory variable on one response category of immunization status. Ordinal logistic regression models were constructed, and the best-fitting model was selected to identify significant immunization status variables. Results: The prevalence of immunization status among children was found to be 72.2% (34.2% fully immunized and 38.0% partially immunized), while about 27.8% of children were non-immunized. The fitted partial proportional odds model revealed that child immunization status was significantly associated with region afar (OR = 7.90; CI: 4.78-11.92), family planning use (OR = 0.69; CI: 0.54-0.88), residence (OR = 2.22;CI: 1.60-3.09), antenatal visit (OR = 0.73;CI: 0.53-0.99), and delivery place (OR = 0.65;CI: 0.50-0.84). Conclusions: Vaccinating children was a significant step forward in improving and protecting child health in Ethiopia. The study showed that the prevalence of non-immunized children varied between rural (33.6%) and uneducated mothers (36.6%). As a result, it is agreeable that treatments are better to focus on targeting essential childhood vaccinations by promoting maternal education, antenatal visits, and maternal access to health care.
PELAYANAN DAN INFORMASI CUSTOMER SERVICE BERBASIS BOT TELEGRAM DENGAN ALGORITMA FORWARD CHAINING PADA CV.PRIMGUARD INDONESIA
Authors: Fathurrozi Ahmad , Karimah Fikriyah
Published: January 2023

CV Primguard Indonesia is a company engaged in the service of managing vehicle documents or documents. Information related to vehicle management is currently not optimal because it only uses customer service as the information provider, so that shorter information-related inquiries will take a lot of customer service time to explain to the customer. The purpose of this research is to provide convenience for customer service in providing an explanation of simple information that can be transferred by bot service. Meanwhile, customer service will explain information to customers if they need more detailed information. The method used is prototyping. The algorithm used is forward chaining so that it can be display the response according to the existing data. In obtaining data, using interviews, observation, and bibliography methods to produce more accurate data. The results of this research are automated bot-based information services using the telegram application. Telegram provides an API that can be used to develop bots. The bot is made using the PHP programming language, MySQL Server database, and Telegram Bot. The conclusion of this study is the use of telegram bot makes it easy for customers to get information quickly without the need to contact customer service directly if the information is only simple.
Penggunanaan Metoda Fuzzy Logic Tsukamoto Untuk Memprediksi Jumlah Penerimaan Peserta Didik Baru ( Studi Kasus TK. Bina Mulia )
Authors: Khaerudin Muhamad , Warta Joni , Achmad Noeman
Published: January 2023

The Bina Mulia Indonesia Education Foundation, currently overseeing the education of young children, is one of the Kindergartens (TK) in the residential area of Villa Mutiara Jaya, Wanajaya Village, Cibitung District which still has the potential to absorb new students based on the large amount of initial data obtained from the academic year. 2018/2019 to 2021/2022, with conditions in recent years greatly affecting the number of new student admissions which has decreased. In this study, a comparative analysis of the Tsukamoto fuzzy logic algorithm method was used, to predict the number of registrants next year seen from the number of students who graduated and registered from the previous year and compared the calculations using the average. the value of the results obtained in the three Tsukamoto fuzzy methods
Analisa Sentimen Efektifitas Vaksin terhadap Varian COVID 19 Omicron Berbasis Leksikon
Authors: Muhammad Ghudafa Taufik Akbar  , Srisulistiowati Dwi Budi
Published: January 2023

One of the ways to control the spread of COVID-19 is vaccination. However, discussions about the effectiveness of vaccines are still visible, especially in various social media. Not yet finished about this, now a new variant of covid 19 has emerged, namely Omicron. The news through the youtube channel is also sought after and seen by people to find out what this omicron virus looks like and the effectiveness of the vaccine that has been carried out by the community against this new virus. In this study, the detection of public opinion about the effectiveness of vaccination using the Support Vector Machine algorithm. The dataset was taken by crawling the YouTube comments of English news channels and then labeling lexicon-based comments using TextBlob and VADER into positive, negative, and neutral comments. There are differences in the number of positive, negative, and neutral comments with the two text labeling methods, but not too far. The application of the SVM algorithm to the dataset with the comment labeling of the TextBlob method resulted in an accuracy of 63%, while the application of the SVM with the comment labeling of the VADER method resulted in an accuracy of 70%.
Rancang Bangun Aplikasi Jasa Cuci Sofa Berbasis Web Menggunakan Metode Prototype Pada PT. Sinar Berkah Sofa
Authors: Rejeki Sri , Hantoro Kusdarnowo , Achmad Noeman
Published: January 2023

This research was made with the aim of reducing the problems that the company has from ordering washing services which are still done manually and there is no price list contained in this service. Therefore, the author aims to design an Application Using Web-Based Sofa Washing Services Prototype Method. The method used in this study is in the form of data collection by conducting observations, interviews, and literature studies, then for the method of analysis using the prototype method, in an object-based method, namely the Unified Modeling Language (UML) which consists of Use Case Diagrams, Activity Diagrams, and sequence diagrams, Class Diagram. Then to design the program using the Hyper Text Preprocessor (PHP) programming language, Sublime Text 3 as a text editor, MySQL as a database. The results of this study are customers can see the price list without having to ask the service and the ordering process no longer uses manual ordering.
Layanan Pengecekan Judul Buku Menggunakan Algoritma Boyer-Moore pada Perpustakaan SDN Sumur Batu 4 Bantargebang Bekasi
Authors: Isnawati  , Handayani Dwipa , Noeman Achmad
Published: January 2023

Sistem penelusuran judul buku diperpustakaan merupakan salah satu bagian dari pengolahan dan pemanfaatan informasi di SDN Sumur Batu  4 Bantargebang Bekasi masih belum terkomputarisasi, pencarian atau penelusuran manual menyebabkan siswa terdapat kesulitan dalam penelusuran buku dan petugas perpustakaan tidak bisa mengontrol buku secara efisien dari permasalahan sekolah tersebut diperlukan suatu sistem yang dapat memecahkan permasalahan sehingga menghasilkan tujuan meningkatkan efisiensi dalam penelusuran buku, membangun sebuah sistem layanan pengecekan judul buku menggunakan algoritma boyer-moore serta memberikan kemudahan bagi seluruh pengguna dalam memanfaatkan penelusuran buku. Dengan penerapan layanan pengecekan judul buku menggunakan algoritma boyer-moore sebagai algoritma yang paling efisien dan menggunakan metode rapid application development dimulai dari planning, workshop desain rapid application development dan implementasi. Metode pengumpulan data yaitu observasi, wawancara, kuisioner dan studi Pustaka. Diharapkan mampu membantu mempercepat proses penelusuran buku pada perpustakaan serta dapat meningkatkan kepuasan pelayanan perpustakaan bagi pengunjung perpustakaan.
Prediksi Barang Sering dan Jarang Terjual Dengan Menggunakan Algorithma K-Mean Clustering (Studi Kasus Toko Bina Mulia)
Authors: Khaerudin Muhamad , Zaenuddin Imam , Tukino
Published: January 2023

Peningkatan jumlah penduduk di wilayah penyangga ibu kota yang pesat berpengaruh terhadap pola hidup masyarakat di wilayah tersebut termasuk di kabupaten Bekasi. Demikian juga dengan pertumbuhan usaha masyarakat kecil dan menengah, salah satunya adalah toko koperasi bina mulia. Penelitian ini dibuat untuk menentukan jenis barang mana saja yang sering terjual dan jenis barang mana saja yang jarang terjual. Algoritma yang digunakan yaitu K-Means Clustering, di mana data dikelompokkan berdasarkan karakteristik yang sama akan dimasukkan ke dalam kelompok yang sama dan set data yang dimasukkan ke dalam kelompok tidak tumpang tindih. Informasi yang ditampilkan berupa kelompok – kelompok nama produk dan jumlah terjual dalam satu minggu selama dua bulan yaitu bulan April dan Mei sebagai sample. Hasil penelitian ini akan membantu pihak Toko dalam menganalisa jenis barang mana yang sering dan yang jarang terjual. Software yang digunakan untuk membantu pengelompokan ini adalah Rapid Miner.
Perancangan ChatBot Pendaftaran Siswa Dengan Telegram BOT Design a Chatbot for Student Registration Using Telegram BOT
Authors: Priambodo Harry , Muhajirin Adi
Published: January 2023

Meningkatnya angka korban covid-19 kian hari membuat kita semakin sadar akan pentingnya protokol kesehatan dari memakai masker, menjaga jarak, selalu cuci tangan, menghindari kerumunan,dan lain lain. Tercatat pada tanggal 19 Mei 2022 sudah ada 6 juta masyarakat indonesia terkonfirmasi positive Covid-19, Namun pada tahun ajaran baru SDN Sriamur 02 masih menerapkan pendaftaran ditempat, dan karena meningkatnya tingkat calon siswa dari tahun ketahun membuat kewalahan petugas admin sekolah, dari hasil observasi awal wali murid SDN Sriamur 02 mayoritas layanan aplikasi yang di gunakan ialah layanan Chatting , selain dapat di pakai dimana saja juga lebih hemat dalam pemakaian kuota internet, oleh karena itu dengan demikian peneliti mendapat kan satu ide untuk membuat Bot yang berjalan pada aplikasi Telegram Messenger yang dapat membantu dalam hal pendaftaran calon siswa, dimana model pengembangan yang akan digunakana peneliti adalah Extreame Programming merupakan sebuah model pengembangan perangkat lunak yang mencoba menyederhanakan berbagai tahapan dalam proses pengembangan tersebut sehingga menjadi lebih adaptif dan fleksibel, Sehingga metode Extreme Programming (XP) lebih mengedepankan proses pengembangan yang lebih responsive terhadap kebutuhan, Penelitian yang dilakukan menghasilkan sebuah sistem yang siap digunakan kapanpun dimanapun selama 24jam dan berhasil melakukan salah satu protokol di era pandemi yaitu social distancing , dan sebuah dataset calon siswa yang disimpan pada database Googlesheet.
Sistem Informasi Pengarsipan Surat Masuk dan Keluar dengan Algoritma Sequential Search di Kelurahan Bahagia
Authors: Aji Tri Furkan Sarjono , Mugiarso  , Ramdhania Khairunnisa Fadhilla
Published: January 2023

Pada Kelurahan Bahagia ditemui permasalahan pengelolaan arsip, terutama pengarsipan surat masuk dan keluar, tepatnya pada pencarian serta penyajian informasi surat, seringkali mengalami keterlambatan dan kesulitan dalam mencari arsip surat tersebut. Penelitian ini, bertujuan untuk membantu Kelurahan Bahagia dalam mengatasi permasalahan arsip surat tersebut, dengan merancang dan mengembangkan sistem informasi pengarsipan surat masuk dan keluar menggunakan metode Rapid Applciation Development (RAD) dan menggunakan algoritma sequential search untuk membantu pencarian informasi surat menjadi lebih cepat dan mudah.  Hasil dari penenlitian ini adalah Sistem informasi pengarsipan surat masuk dan keluar yang dapat membantu mengatasi permasalahan pengarsipan surat di Kelurahan Bahagia.
Rancang Bangun Sistem Informasi Administrasi
Authors: Saputra Naufal Malik Hadi , Srisulistiowati Dwi Budi , Kusmara Hadi
Published: January 2023

SMPN 290 adalah salah satu satuan pendidikan dengan dengan jenjang SMP di Marunda, Kec. Cilincing, Kota Jakarta Utara, DKI Jakarta. Dalam menjalankan kegiatannya, SMPN 290 berada di bawah kementrian pendidikan dan kebudayaan. Berdasarkan wawancara yang dilakukan kepada narasumber SMP Negeri 290 saat ini belum adanya sistem pengarsipan data surat masuk dan surat keluar. Hal ini dapat menimbulkan beberapa aspek kesalahan baik dari pihak sekolah maupun bagian administrasi tersebut, seperti efektif untuk mendata surat yeng keluar maupun yang masuk. Untuk mempermudah pendataan surat masuk mauoun surat keluar maka dirancang sebuah aplikasi sistem informasi administrasi. Dengan adanya aplikasi ini sistem informasi administrasi ini, dapat mempermudah staf bagian arsip disekolah dan dapat meminimalisir kehilangan dan kerusakan sebuah data pengarsipan surat.

 

Kata Kunci : Administrasi, Surat Masuk, Surat Keluar