bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Efficacy and Risk Factors for Failure of Balloon Dilation for Benign Ureteral Stricture
Authors: Wang Bing , Gao Wenzhi , Yang Kunlin , Liu Honglei , Han Yangjun , Diao Mingxin , Zuo Chao , Zhang Minghua , Diao Yingzhi , Li Zhihua , Li Xinfei , Wang Gang , Zhang Peng , Wang Chunji , Xiao Chunjuan , Huang Chen , Gu Yaming , Li Xuesong
Published: February 2023

This study aimed to investigate the efficacy of balloon dilation in ureteral stricture and to analyze the risk factors for the failure of balloon dilation, which will hopefully provide some reference for clinicians to develop treatment plans. We retrospectively analyzed 196 patients who underwent balloon dilation between January 2012 and August 2022, 127 of whom had complete baseline and follow-up data. General clinical data, perioperative data, balloon parameters at the time of surgery, and follow-up results were collected from the patients. Univariate and multivariate logistic regression analyses were performed for the risk factors for surgical failure in patients undergoing balloon dilatation. The success rates of balloon dilatation (n = 30) and balloon dilatation combined with endoureterotomy (n = 37) for lower ureteral stricture at 3 months, 6 months, and 1 year were 81.08%, 78.38%, and 78.38% and 90%, 90%, and 86.67%, respectively. The success rates of balloon dilation at 3 months, 6 months, and 1 year in patients with recurrent upper ureteral stricture after pyeloplasty (n = 15) and primary treatment (n = 30) were 73.33%, 60%, and 53.33% and 80%, 80%, and 73.33%, respectively. The success rates of surgery at 3 months, 6 months, and 1 year for patients with recurrence of lower ureteral stricture after ureteral reimplantation or endoureterotomy (n = 4) and primary treatment with balloon dilatation (n = 34) were 75%, 75%, and 75% and 85.29%, 79.41%, and 79.41%, respectively. Multivariate analysis of the failure of balloon dilation showed that balloon circumference and multiple ureteral strictures were risk factors for balloon dilation failure (OR = 0.143, 95% CI: 0.023–0.895, p = 0.038; OR = 1.221, 95% CI: 1.002–1.491, p = 0.05). Balloon dilation combined with endoureterotomy in lower ureteral stricture had a higher success rate than balloon dilation alone. The success rate of balloon dilation in the primary treatment of the upper and lower ureter was higher than that of balloon dilation in the secondary treatment after failed repair surgery. Balloon circumference and multiple ureteral strictures are risk factors for balloon dilation failure.
Analysis of the Curative Effect of Temporomandibular Joint Disc Release and Fixation Combined with Chitosan Injection in the Treatment of Temporomandibular Joint Osteoarthrosis
Authors: Wu Chuan-Bin , Sun Hai-Jiang , Sun Ning-Ning , Zhou Qing
Published: February 2023

Objective: Temporomandibular joint osteoarthritis (TMJ-OA) is common in clinic. The purpose of this study was to evaluate the efficacy of disc release, fixation and chitosan injection in the treatment of TMJ-OA. Methods: From March 2021 to March 2022, 32 patients who underwent the unilateral reduction and fixation of temporomandibular joint disc release were retrospectively studied. All patients were diagnosed with TMJ-OA and were treated with chitosan injection. This group of patients was analyzed by the visual analog scale (VAS) for pain and improvement of maximum comfortable mouth opening before treatment and 6 months after treatment. A paired t-test was used to evaluate the treatment effect, and p < 0.05 indicated that the difference was statistically significant. Results: All 32 patients were successfully treated by surgery and chitosan injection in the second week after operation. The duration of disease in this group ranged from 1 to 10 months, with an average of 5.7 months. After 6 months of follow up, 30 patients were satisfied with the treatment and two were unsatisfied. The difference in the treatment effect was found to be statistically significant (p < 0.05). Conclusions: Temporomandibular joint disc release and fixation combined with chitosan injection is effective in the treatment of TMJ-OA.
Blade Augmentation in Nailing Proximal Femur Fractures—An Advantage despite Higher Costs?
Authors: Böhringer Alexander , Cintean Raffael , Eickhoff Alexander , Gebhard Florian , Schütze Konrad
Published: February 2023

Background: Proximal femoral fractures occur with increasing incidence, especially in the elderly. Commonly used implants for surgical treatment are cephalomedullary nails. To increase stability, a perforated femoral neck blade can be augmented with cement. The study investigated whether this results in a relevant clinical advantage and justifies the higher cost. Materials and methods: This is a single-center retrospective study of 620 patients with proximal femur fractures treated with cephalomedullary nailing. Between January 2016 and December 2020, 207 male and 413 female patients were surgically treated with a proximal femur nail (DePuy Synthes) using a perforated blade and cement augmentation in cases with severe osteoporosis. Primary outcome measures were the rate of cut-out, tip apex distance and the positioning of the blade in the femoral head. Secondary outcome measures were the implant costs and operating times. Results: Of the 620 femoral neck blades, 299 were augmented with cement. A total of six cut-outs were seen in the first 3 months after the operation. There were three in the cement-augmented group (CAB = cement-augmented blade) and three in the conventional group (NCAB = non-cement-augmented blade). There was a significant positive correlation between age and augmentation, with a mean difference of 11 years between the two groups (CAB 85.7 ± 7.9 vs. NCAB 75.3 ± 15.1; p < 0.05). There was no difference in the tip-apex distance (CAB 15.97 vs. 15.69; p = 0.64) or rate of optimal blade positions between the groups (CAB 81.6% vs. NCAB 83.2%; p = 0.341). Operation times were significantly longer in the cemented group (CAB 62.6 21.2 min vs. NCAB 54.1 7.7 min; p < 0.05), and the implant cost nearly doubled due to augmentation. Conclusion: When the principles of anatomic fracture reduction, optimal tip-apex distance and optimal blade position are combined with cement augmentation in cases of severe osteoporosis, a cut-out rate of less than 1% can be achieved. Nevertheless, it should be noted that augmentation remains expensive and prolongs surgery time without definite proof of mechanical superiority.
Intra-Articular Injections into the Inferior versus Superior Compartment of the Temporomandibular Joint: A Systematic Review and Meta-Analysis
Authors: Chęciński Maciej , Chęcińska Kamila , Turosz Natalia , Sikora Maciej , Chlubek Dariusz
Published: February 2023

This systematic review and meta-analysis aimed to validate the hypothesis that intra-articular injections into the inferior temporomandibular joint compartment are more efficient than analogous superior compartment interventions. Publications reporting differences between the above-mentioned techniques in the domains of revealing articular pain, decreasing the Helkimo index, and abolishing mandibular mobility limitation were included. Medical databases covered by the Bielefeld Academic Search Engine, Google Scholar, PubMed, ResearchGate, and Scopus engines were searched. The risk of bias was assessed using dedicated Cochrane tools (RoB2, ROBINS-I). The results were visualized with tables, charts, and a funnel plot. Six reports describing five studies with a total of 342 patients were identified. Of these, four trials on a total of 337 patients were qualified for quantitative synthesis. Each eligible report was at moderate risk of bias. From 19% to 51% improvement in articular pain, 12–20% lower Helkimo index, and 5–17% higher maximum mouth opening were observed. The evidence was limited by the small number of eligible studies, discrepancies regarding the substances used, possible biases, and the differences in observation times and scheduled follow-up visits. Despite the above, the advantage of inferior over superior compartment temporomandibular joint intra-articular injections is unequivocal and encourages further research in this direction.
Dyslipidemia Treatment and Lipid Control in US Adults with Diabetes by Sociodemographic and Cardiovascular Risk Groups in the NIH Precision Medicine Initiative All of Us Research Program
Authors: Akbarpour Meleeka , Devineni Divya , Gong Yufan , Wong Nathan
Published: February 2023

Real-world data on lipid levels and treatment among adults with diabetes mellitus (DM) are relatively limited. We studied lipid levels and treatment status in patients with DM across cardiovascular disease (CVD) risk groups and sociodemographic factors. In the All of Us Research Program, we categorized DM as (1) moderate risk (≤1 CVD risk factor), (2) high risk (≥2 CVD risk factors), and (3) DM with atherosclerotic CVD (ASCVD). We examined the use of statin and non-statin therapy as well as LDL-C and triglyceride levels. We studied 81,332 participants with DM, which included 22.3% non-Hispanic Black and 17.2% Hispanic. A total of 31.1% had ≤1 DM risk factor, 30.3% had ≥2 DM risk factors, and 38.6% of participants had DM with ASCVD. Only 18.2% of those with DM and ASCVD were on high-intensity statins. Overall, 5.1% were using ezetimibe and 0.6% PCSK9 inhibitors. Among those with DM and ASCVD, only 21.1% had LDL-C < 70 mg/dL. Overall, 1.9% of participants with triglycerides ≥ 150 mg/dL were on icosapent ethyl. Those with DM and ASCVD were more likely to be on high-intensity statins, ezetimibe, and icosapent ethyl. Guideline-recommended use of high-intensity statins and non-statin therapy among our higher risk DM patients is lacking, with LDL-C inadequately controlled.
Clinical Profile of Patients with Idiopathic Pulmonary Fibrosis in Real Life
Authors: Morena Diego , Fernández Jesús , Campos Carolina , Castillo María , López Guillermo , Benavent María , Izquierdo José Luis
Published: February 2023

Objective: The objective of this study is to define the real-life clinical profile and therapeutic management of patients with idiopathic pulmonary fibrosis using artificial intelligence. Methods: We have conducted an observational, retrospective, non-interventional study using data from the Castilla-La Mancha Regional Healthcare Service (SESCAM) in Spain between January 2012 and December 2020. The Savana Manager 3.0 artificial intelligence platform was used to collect information from electronic medical records by applying natural language processing. Results: Our study includes 897 subjects whose diagnosis was compatible with idiopathic pulmonary fibrosis; 64.8% were men, with a mean age of 72.9 years (95% CI 71.9–73.8), and 35.2% were women, with a mean age of 76.8 years (95% CI 75.5–78). Patients who had a family history of IPF (98 patients; 12%) were younger and predominantly female (53.1%). Regarding treatment, 45% of patients received antifibrotic therapy. Patients who had undergone lung biopsy, chest CT, or bronchoscopy were younger than the patient population in whom these studies were not completed. Conclusions: This study has used artificial intelligence techniques to analyze a large population over a 9-year period and determine the situation of IPF in standard clinical practice by identifying the patient clinical profile, use of diagnostic tests and therapeutic management.
Renal and Endocrine Responses to Arm Exercise in Persons with Cervical Spinal Cord Injury
Authors: Mukai Yuki , Kawasaki Takashi , Kamijo Yoshi-ichiro , Furusawa Kazunari , Ibusuki Tatsuru , Sakurai Yuta , Nishimura Yukihide , Umemoto Yasunori , Tajima Fumihiro
Published: February 2023

The aim of this study was to assess renal functions and endocrine responses to arm exercise in persons with cervical spinal cord injury (CSCI) under euhydrated conditions (free drinking of water), and to determine the physiological effects of exercise on renal function in these subjects. Eleven CSCI individuals (spinal lesions between C6 and C8, American Spinal Injury Association impairment scale A) and nine able-bodied (AB) persons rested for 30 min before performing 30 min arm-crank ergometer exercises at 50% of their maximum oxygen consumption, followed by 60-min of rest/recovery. Urine and blood samples were collected before and immediately after the exercise and recovery period. The CSCI patients showed no increase in plasma adrenaline and plasma renin activity compared with the AB controls, but showed similar changes in plasma aldosterone and the plasma antidiuretic hormone in response to the exercise. Creatinine clearance, osmolal clearance, free water clearance, and the fractional excretion of Na+ did not change during exercise in both groups of subjects, however free water clearance in the CSCI group was higher than in the AB group throughout the study. These findings suggested that activated plasma aldosterone without an increase in adrenaline or renin activity during exercise in CSCI individuals may reflect an adaptation to the disturbance of the sympathetic nervous system to compensate for renal function. As a result, no adverse effects of exercise on renal function in CSCI patients were observed.
COVID-19-Related Neuropathic Pain: A Systematic Review and Meta-Analysis
Authors: Williams Laura , Zis Panagiotis
Published: February 2023

Introduction: SARS-CoV-2, responsible for the coronavirus disease (COVID-19) pandemic, may impact other systems apart from the respiratory system, including the nervous system. In this systematic review, we aimed to establish the prevalence and determinants of neuropathic pain amongst COVID-19-infected individuals. Methodology: A literature search in the PubMed database was performed and 11 papers were eligible for inclusion in this systematic review and meta-analysis. Results: The pooled prevalence of COVID-19-related neuropathic pain was 6.7% (95% CI: 4.7–9.5%) for hospitalised patients during the acute phase and 34.3% (95% CI: 14.3–62%) for long COVID patients. The identified risk factors for COVID-19-related neuropathic pain development included depression, COVID-19 severity and azithromycin use. Conclusions: Neuropathic pain is a very common symptom in long COVID, indicating the urgency for further research in this direction.
Asymmetric Intrastromal Corneal Ring Segments with Progressive Base Width and Thickness for Keratoconus: Evaluation of Efficacy and Analysis of Epithelial Remodeling
Authors: Benlarbi Abdelmajid , Kallel Sofiene , David Clementine , Barugel Raphael , Hays Quentin , Goemaere Isabelle , Cuyaubere Roxane , Borderie Marie , Borderie Vincent , Bouheraoua Nacim
Published: February 2023

Purpose: The aim of this study is to describe visual outcomes and epithelial remodeling following the implantation of asymmetric intracorneal ring segments (ICRSs) of variable thickness and base width for the management of duck-type keratoconus. Methods: A prospective observational study of patients with duck-type keratoconus was conducted. All patients received one ICRS AJL PRO + implant (AJL Ophthalmic). We analyzed demographic and clinical data, anterior segment optical coherence tomography (AS-OCT) data and Scheimpflug camera images obtained with a Placido disc MS-39 (CSO, Firenze, Italy) one and six months after surgery to determine keratometric and aberrometric outcomes and epithelial remodeling. Results: We studied 33 keratoconic eyes. ICRS implantation significantly improved both corrected distance visual acuity (CDVA) and uncorrected distance visual acuity at six months, as assessed with the logMAR (minimum angle of resolution) system, from 0.32 ± 0.19 to 0.12 ± 0.12 (p < 0.001) and from 0.75 ± 0.38 to 0.37 ± 0.24 (p < 0.001), respectively. Overall, 87% of implanted eyes gained ≥ 1 line of CDVA, and 3% of patients (n = 1) lost one line of CDVA; 55% of eyes attained a manifest refraction spherical equivalent between +1.50 and −1.50 D. Epithelial remodeling was greater at the wider and thicker end (+11.33 µm ± 12.95; p < 0.001 relative to the initial value) than at the narrower and thinner end (+2.24 µm ± 5.67; p = 0.01). Coma aberration was significantly reduced from 1.62 ± 0.81 µm to 0.99 ± 0.59 µm (p < 0.001). Conclusions: AJL-PRO + ICRS implantation for duck-type keratoconus improves refractive, topographic, aberrometric and visual parameters and induces progressive epithelial thickening along the segment.
Application of an Intraoperative Limb Positioner for Adjustable Traction in Both-Column Fractures of the Acetabulum: A Technical Note with Clinical Outcome
Authors: Kim Joon-Woo , Oh Chang-Wug , Park Kyeong-Hyeon , Hong Won-Ki , Yoon Sung-Hyuk , Lee Gwang-Sub , Oh Jong-Keon
Published: February 2023

Traction of the ipsilateral leg is usually required to facilitate fracture reduction while operating both-column acetabular fractures. However, it is challenging to maintain constant traction manually during the operation. Herein, we surgically treated such injuries while maintaining traction using an intraoperative limb positioner and investigated the outcomes. This study included 19 patients with both-column acetabular fractures. Surgery was performed after the patient’s condition had stabilized, at an average of 10.4 days after injury. The Steinmann pin was transfixed to the distal femur and connected to a traction stirrup; subsequently, the construct was affixed to the limb positioner. A manual traction force was applied through the stirrup and maintained with the limb positioner. Using a modified Stoppa approach combined with the lateral window of the ilioinguinal approach, the fracture was reduced, and plates were applied. Primary union was achieved in all cases at an average of 17.3 weeks. The quality of reduction at the final follow-up was found to be excellent, good, and poor in 10, 8, and 1 patients, respectively. The average Merle d’Aubigné score at the final follow-up was 16.6. Surgical treatment of both-column acetabular fracture using intraoperative traction with a limb positioner yields satisfactory radiological and clinical outcomes.
Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment
Authors: Nicol Vanina , Verdaguer Claire , Daste Camille , Bisseriex Hélène , Lapeyre Éric , Lefèvre-Colau Marie-Martine , Rannou François , Rören Alexandra , Facione Julia , Nguyen Christelle
Published: February 2023

Chronic low back pain (cLBP) is a public and occupational health problem that is a major professional, economic and social burden. We aimed to provide a critical overview of current international recommendations regarding the management of non-specific cLBP. We conducted a narrative review of international guidelines for the diagnosis and conservative treatment of people with non-specific cLBP. Our literature search yielded five reviews of guidelines published between 2018 and 2021. In these five reviews, we identified eight international guidelines that fulfilled our selection criteria. We added the 2021 French guidelines into our analysis. Regarding diagnosis, most international guidelines recommend searching for so-called yellow, blue and black flags, in order to stratify the risk of chronicity and/or persistent disability. The relevance of clinical examination and imaging are under debate. Regarding management, most international guidelines recommend non-pharmacological treatments, including exercise therapy, physical activity, physiotherapy and education; however, multidisciplinary rehabilitation, in selected cases, is the core treatment recommended for people with non-specific cLBP. Oral, topical or injected pharmacological treatments are under debate, and may be offered to selected and well-phenotyped patients. The diagnosis of people with cLBP may lack precision. All guidelines recommend multimodal management. In clinical practice, the management of individuals with non-specific cLBP should combine non-pharmacological and pharmacological treatments. Future research should focus on improving tailorization.
Effect of Digitalis on ICD or CRT-D Recipients: A Systematic Review and Meta-Analysis
Authors: Zhuo Wen , Liu Hualong , Fu Linghua , Fan Weiguo , Hong Kui
Published: February 2023

Background: Digitalis has been widely utilized for heart failure therapy and several studies have demonstrated an association of digitalis and adverse outcome events in patients receiving implantable cardioverter defibrillators (ICDs) or cardiac resynchronization therapy defibrillators (CRT-Ds). Hence, we conducted this meta-analysis to assess the effect of digitalis on ICD or CRT-D recipients. Methods: We systematically retrieved relevant studies using the Cochrane Library, PubMed, and Embase database. A random effect model was used to pool the effect estimates (hazard ratios (HRs) and 95% confidence intervals (CIs)) when the studies were of high heterogeneity, otherwise a fixed effect model was used. Results: Twenty-one articles containing 44,761 ICD or CRT-D recipients were included. Digitalis was associated with an increased rate of appropriate shocks (HR = 1.65, 95% CI: 1.46–1.86, p < 0.001) and a shortened time to first appropriate shock (HR = 1.76, 95% CI: 1.17–2.65, p = 0.007) in ICD or CRT-D recipients. Furthermore, the all-cause mortality increased in ICD recipients with digitalis therapy (HR = 1.70, 95% CI: 1.34–2.16, p < 0.01), but the all-cause mortality was unchanged in CRT-D recipients (HR = 1.55, 95% CI: 0.92–2.60, p = 0.10) or patients who received ICD or CRT-D therapy (HR = 1.09, 95% CI: 0.80–1.48, p = 0.20). The sensitivity analyses confirmed the robustness of the results. Conclusion: ICD recipients with digitalis therapy may tend to have higher mortality rates, but digitalis may not be associated with the mortality rate of CRT-D recipients. Further studies are required to confirm the effects of digitalis on ICD or CRT-D recipients.
“I Have Eight Different Files at Eight Different Places”: Perspectives of Youths and Their Family Caregivers on Transitioning from Pediatric to Adult Rehabilitation and Community Services
Authors: Kokorelias Kristina M. , Lee Tin-Suet Joan , Bayley Mark , Seto Emily , Toulany Alene , Nelson Michelle L. A. , Dimitropoulos Gina , Penner Melanie , Simpson Robert , Munce Sarah E. P.
Published: February 2023

Introduction: The number of young adults (youth) living with childhood-onset disabilities, and requiring transitional support to adult community and rehabilitation services, is increasing. We explored facilitators and barriers to accessing and sustaining community and rehabilitation services during the transition from pediatric to adult care. Methods: A qualitative descriptive study was conducted in Ontario, Canada. Data were collected through interviews with youth (n = 11) and family caregivers (n = 7). The data were coded and analyzed using thematic analysis. Results: Youth and caregivers face many types of transitions from pediatric to adult community and rehabilitation services, e.g., those related to education, living arrangements, and employment. This transition is marked by feelings of isolation. Supportive social networks, continuity of care (i.e., same care providers), and advocacy all contribute to positive experiences. Lack of knowledge about resources, changing parental involvement without preparation, and a lack of system responses to evolving needs were barriers to positive transitions. Financial circumstances were described as either a barrier or facilitator to service access. Conclusions: This study demonstrated that continuity of care, support from providers, and social networks all contribute markedly to the positive experience of transitioning from pediatric to adult services for individuals with childhood-onset disabilities and family caregivers. Future transitional interventions should incorporate these considerations.
Biomedical Applications of Blow-Spun Coatings, Mats, and Scaffolds—A Mini-Review
Authors: Mobaraki Mohammadmahdi , Liu Meichen , Masoud Abdul-Razak , Mills David K.
Published: February 2023

Human tissues and disease models require well-defined biomimetic microenvironments. During the past decade, innovative developments in materials science, microfabrication, and polymer science have provided us with the ability to manipulate cellular microenvironments for regenerative medicine and tissue engineering applications. Solution blow spinning is a facile fiber fabricating method that requires a simple apparatus, a concentrated polymer solution within a volatile solvent, and a high-pressure gas source. Commercially available airbrushes, typically used for painting and cosmetic makeup, have successfully generated a range of nanofibers and films. Applications under investigation are similar to electrospinning and include enzyme immobilization, drug delivery, filtration, infection protection, tissue engineering, and wound healing. This review will discuss fiber fabrication methods before a more detailed discussion of the potential of blow-spinning in biomedical applications.
The Effect of Pulse Current on Electrolytically Plating Nickel as a Catalyst for Grafting Carbon Nanotubes onto Carbon Fibers via the Chemical Vapor Deposition Method
Authors: Tanaka Kazuto , Kyoyama Shuhei
Published: February 2023

Carbon nanotubes (CNTs) can be directly grafted onto the surface of carbon fibers using the chemical vapor deposition method, in which nanometer-order nickel (Ni) particles, serving as catalysts, are plated onto the surface of carbon fibers via electrolytic plating. In our previous studies, in which a direct current (DC) was used to electrolytically plate Ni onto carbon fibers as a catalyst, the site densities and diameters of Ni particles increased simultaneously with the plating time, making it difficult to independently control the site densities and diameters of the particles. On the other hand, pulse current (PC) plating is attracting attention as a plating technique that can control the deposition morphology of nuclei. In this study, we clarify the effect of the parameters of the PC on the particle number per unit area (site density) and the particle diameters of Ni particles plated onto the surface of carbon fibers, using the PC to electrolytically plate Ni. Electrolytically plating Ni onto carbon fibers (via PC) after the removal of the sizing agent enable Ni particles with sparser site densities and larger diameters to be plated than those plated via DC. Using Ni particles with sparse site densities, it is shown that CNTs with sparse site densities can be grafted.
Developing an Echocardiography-Based, Automatic Deep Learning Framework for the Differentiation of Increased Left Ventricular Wall Thickness Etiologies
Authors: Li James , Chao Chieh-Ju , Jeong Jiwoong Jason , Farina Juan Maria , Seri Amith R. , Barry Timothy , Newman Hana , Campany Megan , Abdou Merna , O’Shea Michael , Smith Sean , Abraham Bishoy , Hosseini Seyedeh Maryam , Wang Yuxiang , Lester Steven , Alsidawi Said , Wilansky Susan , Steidley Eric , Rosenthal Julie , Ayoub Chadi , Appleton Christopher P. , Shen Win-Kuang , Grogan Martha , Kane Garvan C. , Oh Jae K. , Patel Bhavik N. , Arsanjani Reza , Banerjee Imon
Published: February 2023

Aims:Increased left ventricular (LV) wall thickness is frequently encountered in transthoracic echocardiography (TTE). While accurate and early diagnosis is clinically important, given the differences in available therapeutic options and prognosis, an extensive workup is often required to establish the diagnosis. We propose the first echo-based, automated deep learning model with a fusion architecture to facilitate the evaluation and diagnosis of increased left ventricular (LV) wall thickness. Methods and Results: Patients with an established diagnosis of increased LV wall thickness (hypertrophic cardiomyopathy (HCM), cardiac amyloidosis (CA), and hypertensive heart disease (HTN)/others) between 1/2015 and 11/2019 at Mayo Clinic Arizona were identified. The cohort was divided into 80%/10%/10% for training, validation, and testing sets, respectively. Six baseline TTE views were used to optimize a pre-trained InceptionResnetV2 model. Each model output was used to train a meta-learner under a fusion architecture. Model performance was assessed by multiclass area under the receiver operating characteristic curve (AUROC). A total of 586 patients were used for the final analysis (194 HCM, 201 CA, and 191 HTN/others). The mean age was 55.0 years, and 57.8% were male. Among the individual view-dependent models, the apical 4-chamber model had the best performance (AUROC: HCM: 0.94, CA: 0.73, and HTN/other: 0.87). The final fusion model outperformed all the view-dependent models (AUROC: HCM: 0.93, CA: 0.90, and HTN/other: 0.92). Conclusion: The echo-based InceptionResnetV2 fusion model can accurately classify the main etiologies of increased LV wall thickness and can facilitate the process of diagnosis and workup.
The Role of Artificial Intelligence in Echocardiography
Authors: Barry Timothy , Farina Juan Maria , Chao Chieh-Ju , Ayoub Chadi , Jeong Jiwoong , Patel Bhavik N. , Banerjee Imon , Arsanjani Reza
Published: February 2023

Echocardiography is an integral part of the diagnosis and management of cardiovascular disease. The use and application of artificial intelligence (AI) is a rapidly expanding field in medicine to improve consistency and reduce interobserver variability. AI can be successfully applied to echocardiography in addressing variance during image acquisition and interpretation. Furthermore, AI and machine learning can aid in the diagnosis and management of cardiovascular disease. In the realm of echocardiography, accurate interpretation is largely dependent on the subjective knowledge of the operator. Echocardiography is burdened by the high dependence on the level of experience of the operator, to a greater extent than other imaging modalities like computed tomography, nuclear imaging, and magnetic resonance imaging. AI technologies offer new opportunities for echocardiography to produce accurate, automated, and more consistent interpretations. This review discusses machine learning as a subfield within AI in relation to image interpretation and how machine learning can improve the diagnostic performance of echocardiography. This review also explores the published literature outlining the value of AI and its potential to improve patient care.
LiDAR-Based Sensor Fusion SLAM and Localization for Autonomous Driving Vehicles in Complex Scenarios
Authors: Dai Kai , Sun Bohua , Wu Guanpu , Zhao Shuai , Ma Fangwu , Zhang Yufei , Wu Jian
Published: February 2023

LiDAR-based simultaneous localization and mapping (SLAM) and online localization methods are widely used in autonomous driving, and are key parts of intelligent vehicles. However, current SLAM algorithms have limitations in map drift and localization algorithms based on a single sensor have poor adaptability to complex scenarios. A SLAM and online localization method based on multi-sensor fusion is proposed and integrated into a general framework in this paper. In the mapping process, constraints consisting of normal distributions transform (NDT) registration, loop closure detection and real time kinematic (RTK) global navigation satellite system (GNSS) position for the front-end and the pose graph optimization algorithm for the back-end, which are applied to achieve an optimized map without drift. In the localization process, the error state Kalman filter (ESKF) fuses LiDAR-based localization position and vehicle states to realize more robust and precise localization. The open-source KITTI dataset and field tests are used to test the proposed method. The method effectiveness shown in the test results achieves 5–10 cm mapping accuracy and 20–30 cm localization accuracy, and it realizes online autonomous driving in complex scenarios.
High Cognitive Ability and Mental Health: Findings from a Large Community Sample of Adolescents
Authors: Lavrijsen Jeroen , Verschueren Karine
Published: February 2023

Whereas it has sometimes been asserted that the intellectually gifted would be more prone to develop mental health problems, empirical studies generally do not seem to support such claims. However, much of the available research has relied on preselected samples, introducing risks for sample selection bias. This study scrutinized the relationship between intellectual giftedness (defined as high cognitive ability) and mental health in a large, non-selective sample of early adolescents (n = 3409; 49.6% boys; Mage = 12.5 years). Using a standardized intelligence test (CoVaT-CHC) to identify participants with a high cognitive ability (IQ ≥ 120; n = 403), we compared self- and parent-reported levels of emotional problems, conduct problems, hyperactivity/inattention, and self-reported worry and global self-esteem between high and average ability adolescents. Findings indicated that adolescents with a high cognitive ability were not at increased risk of psychological maladjustment; if any, differences were in favor of the high ability group. However, adolescents who had been formally identified as gifted (i.e., who had received a gifted label) did report worse adjustment for a number of outcomes.
Impacts of Cognitive Factors on Creativity Quality in Design: Identification from Performances in Recall, Association and Combination
Authors: Yin Yuan , Zuo Haoyu , Childs Peter
Published: February 2023

The reason why people have different creativity quality levels may depend on their different performances relating to other cognitive factors that are important for creativity. This study was designed to identify the performance of three cognitive factors (recall, association, and combination) that a designer may use in a creative process and then identify how the differing performance for these cognitive factors will affect creativity quality levels. Seventy-one participants were recruited to undertake a design task and complete a semi-structured interview. The results indicate that, in a creative design process, similar performances in recall, association, and combination can result in differences in creativity quality level.
A Control Method for Water Cannon of Unmanned Fireboats Considering Wind and Ship Motion Disturbances
Authors: Gao Diju , Xie Weixi , Bao Chunteng , Liu Bin , Zhuang Jiaxing
Published: February 2023

In order to realize accurate and fast firefighting at sea, a control method for water cannons of unmanned fireboats considering wind and ship motion disturbances is presented. This method combines information fusion, computer vision, and prediction technology based on neural network. Firstly, a prediction model of the jet trajectory of the fire water cannon considering the disturbances of constant horizontal wind is established, and the effective range of the water cannon’s angles under the target working environment is obtained. Secondly, fusing the visual recognition information and predicted ship motion attitudes information, a double adaptive fuzzy controller is designed to compensate for the disturbances caused by the change in ship motion attitudes. Meanwhile, the online particle swarm optimization (PSO) is applied to fuzzy control to improve operational accuracy while enhancing the ability to adapt to environmental changes. The proposed control method was experimentally verified. As a result, the adaptive fuzzy controller based on the PSO can self-adjust the parameters to adapt to the changes in the working environment within 0.6 s, and the efficiency is improved by about 20%∼50% compared with the traditional fuzzy control. The double adaptive fuzzy control can reach a stable and effective working state within 10 simulation steps, and the RMSE of the drop point error is only 3 ×10−3 m for 40 simulation steps after stabilization, which can effectively resist disturbances and improve efficiency and control accuracy. The control method can provide a practical reference for engineering applications of water cannon control of unmanned fireboats.
Normal Operating Performance Study of 15 MW Floating Wind Turbine System Using Semisubmersible Taida Floating Platform in Hsinchu Offshore Area
Authors: Tong Hoi-Yi , Lin Tsung-Yueh , Chau Shiu-Wu
Published: February 2023

This study predicted the motion response and power performance of a floating wind turbine system equipped with a semisubmersible Taida platform, an IEA 15 MW wind turbine, and a 3 × 2 mooring design in the Hsinchu offshore area in the Taiwan Strait. The hydrodynamic properties were calculated using ANSYS-AQWA and STAR-CCM+. The motion equations were solved by OrcaFlex to obtain the motion response and generator power, as well as the dynamics of the mooring system and aerodynamics of the wind turbine. The waves were assumed to share the same direction as the wind. This study compared the mean values and standard deviations of the motion response, generator power, and mooring line tension between the potential- and viscous-flow approaches by considering the combination of seven wind directions and four current directions under two wave conditions in the Hsinchu offshore area. The numerical prediction shows that the viscous effect has a larger impact on the hydrodynamic properties in the heave, roll, and pitch motions. The angle between the leading mooring line of the system and dominant wind direction in the Taiwan Strait, which comes from the northeast, should be from 120° to 180° in order to deliver a relatively favorable performance of the system.
Dynamic Biobanking for Advancing Breast Cancer Research
Authors: Abdollahyan Maryam , Gadaleta Emanuela , Asif Millahat , Oscanoa Jorge , Barrow-McGee Rachel , Jones Samantha , Jones Louise J , Chelala Claude
Published: February 2023

Longitudinal patient biospecimens and data advance breast cancer research through enabling precision medicine approaches for identifying risk, early diagnosis, improved disease management and targeted therapy. Cancer biobanks must evolve to provide not only access to high-quality annotated biospecimens and rich associated data, but also the tools required to harness these data. We present the Breast Cancer Now Tissue Bank centre at the Barts Cancer Institute as an exemplar of a dynamic biobanking ecosystem that hosts and links longitudinal biospecimens and multimodal data including electronic health records, genomic and imaging data, offered alongside integrated data sharing and analytics tools. We demonstrate how such an ecosystem can inform precision medicine efforts in breast cancer research.
Differences between Squamous Cell Carcinomas of the Base of the Tongue and the Tonsils in Prevalence of HPV16 Infection, Its Type, and Clinical Features
Authors: Biesaga Beata , Mucha-Małecka Anna , Janecka-Widla Anna , Małecki Krzysztof
Published: February 2023

Regarding attempts to find de-escalation methods of treatment for patients with HPV16-positive squamous cell carcinoma of the oropharynx (OPSCC), there is an urgent need to identify new prognostic factors which allow physicians to differentiate the prognosis of these patients. The aim of the study is to compare the incidence of transcriptionally active HPV16 infection and its type as well as other epidemiological, clinical, and histopathological features between SCC of the base of the tongue (BOTSCC) and tonsils (TSSCC). The analysis was performed in a group of 63 patients with OPSCC, for which, in our earlier studies, we assessed transcriptionally active HPV16 infection and its type (viral load and viral genome status). Transcriptionally active HPV16 infection was significantly more common in TSSCC (96.3%) than in BOTSCC (3.7%). Patients with TSSCC had significantly higher disease-free survival rates (84.1%) than those with BTSCC (47.4%); the same was true in the subgroup with HPV16 positivity. The obtained results are an important indication for further research on the development of new prognostic and/or predictive factors for patients with HPV16-positive squamous cell carcinomas of the oropharynx.
The Role of Molecular Imaging in Personalized Medicine
Authors: Salih Suliman , Elliyanti Aisyah , Alkatheeri Ajnas , AlYafei Fatima , Almarri Bashayer , Khan Hasina
Published: February 2023

The concept of personalized medicine refers to the tailoring of medical treatment to each patient’s unique characteristics. Scientific advancements have led to a better understanding of how a person’s unique molecular and genetic profile makes them susceptible to certain diseases. It provides individualized medical treatments that will be safe and effective for each patient. Molecular imaging modalities play an essential role in this aspect. They are used widely in screening, detection and diagnosis, treatment, assessing disease heterogeneity and progression planning, molecular characteristics, and long-term follow-up. In contrast to conventional imaging approaches, molecular imaging techniques approach images as the knowledge that can be processed, allowing for the collection of relevant knowledge in addition to the evaluation of enormous patient groups. This review presents the fundamental role of molecular imaging modalities in personalized medicine.
Quantitatively Evaluating the Ecological Product Value of Nine Provinces in the Yellow River Basin from the Perspective of the Dual-Carbon Strategy
Authors: Zhang Yang , Ma Zijun , Sun Meng , Song Jianing , Yang Yang , Li Qiang , Jing Ying
Published: February 2023

At the 75th session of the United Nations General Assembly, China formally proposed the goal of achieving carbon peak by 2030 and carbon neutrality by 2060, which is called the dual-carbon strategy. In this study, we incorporated the dual-carbon strategy perspective into ecological product value (EPV) evaluation. The EPV is the sum of the final product and service value provided by regional ecosystems for human production and life. A significant uncertainty exists in evaluating the EPV. To bridge this gap, we explored the quantitative evaluation index system of EPV based on the dual-carbon perspective and conducted an empirical analysis relating to four subindexes (ecological protection, ecological products carbon neutral capacity transformation, ecological value, and ecological product value realization safeguard mechanism). The EPV in nine provinces of the Yellow River basin in 2020 was measured. The results showed that the total evaluation score of EPV realization in the Yellow River basin was relatively low, and the average scores of ecological product protection level, carbon neutrality capacity, value transformation level, and value realization guarantee mechanism were all at a low level. Overall, the protection level of ecological products and the guarantee mechanism to realize the EPV were relatively good. However, the carbon neutrality capacity and the value transformation level were relatively poor. From the spatial perspective, the value realization level of ecological products was roughly upstream region > downstream region > midstream region in the Yellow River basin. Finally, corresponding countermeasures and suggestions are put forward according to the comprehensive evaluation index of EPV realization and analysis of the four subindexes.
Translanguaging Framework for Deaf Education
Authors: Wolbers Kimberly , Holcomb Leala , Hamman-Ortiz Laura
Published: February 2023

In this conceptual article, the authors introduce the Translanguaging Framework for Deaf Education (TFDE), drawing upon two perspectives on language and learning: crip linguistics and critical translanguaging space. The TFDE is a retheorization of the Language Zone, a pedagogical framework for supporting language learning in deaf education, and is designed to support educators to approach language use and users from an asset-oriented perspective. In line with this stance, the TFDE validates the linguistic resources deaf students bring to the classroom and encourages students’ full use of their communicative repertoires for meaning making, while also working to expand their linguistic resources and increase communicative flexibility. Examples of translanguaging pedagogical practices with deaf students, such as coming to a shared understanding, building metalinguistic knowledge, and honing communication for external audiences, are explained and illustrated through classroom scenarios with deaf students. Readers are also provided with tools for critically analyzing the social context to ensure accessible and equitable language environments for deaf students and to protect spaces for the use of minoritized languages such as ASL.
Photobiomodulation with Blue Light on Wound Healing: A Scoping Review
Authors: Prado Thais P. , Zanchetta Flávia Cristina , Barbieri Beatriz , Aparecido Caroline , Melo Lima Maria Helena , Araujo Eliana P.
Published: February 2023

Background: Photobiomodulation consists of inducing healing by irradiating light. This scoping review investigates the effect of blue light on the healing process. Methods: The MEDLINE, Web of Science, Scopus, and CINAHL databases were searched. Two reviewers independently examined the search results and extracted data from the included studies. A descriptive analysis was performed. Results: Twenty-two articles were included. Studies were categorized as in vitro/mixed, preclinical, and clinical. The power density used was 10–680 mW/cm2 in most of the in vitro/preclinical studies, the irradiation time ranged from 5 s to 10 min, and different wavelengths and energy densities were used. In clinical studies, the wavelength ranged from 405 to 470 nm, and the energy density varied from 1.5 to 30 J/cm2. Conclusions: A low energy density (<20 J/cm2) was able to stimulate the different cell types and proteins involved in healing, while a high energy density, 20.6–50 J/cm2, significantly reduced cell proliferation, migration, and metabolism. There is a great variety of device parameters among studies, and this makes it difficult to conclude what the best technical specifications are. Thus, further studies should be performed in order to define the appropriate parameters of light to be used.