bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute phase protein and vitamin D concentration in dogs with multicentric lymphoma
Authors: Rocha Michelle do Carmo Pereira , Garnica Taismara Kustro , Fukumasu Heidge , Ramirez Ricardo Andres , Pazzini Josiane Morais , Sueiro Felipe Augusto Ruiz , Paiva Felipe Noleto de , Nardi Andrigo Barboza De
Published: September 2022

Abstract This study aimed to evaluate the serum concentration of vitamin D (25-Hydroxyvitamin D) and acute phase proteins (APPs; alpha-1 acid glycoprotein, haptoglobin, transferrin, ceruloplasmin, albumin, IgA, IgG and alpha-1 - antitrypsin) as potential biomarkers for prognostic and therapy response in dogs with multicentric lymphoma submitted to the CHOP (Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) chemotherapy protocol. Thirteen dogs with multicentric lymphoma classified as high grade by cytology were included in the treatment group (GL), while ten healthy dogs were included in the control group (GC). Serum was collected in the weeks T0, T5 and T10 of CHOP chemotherapy protocol, for the GL group, and in a single collection, for the GC group. All the collected samples were evaluated for the APPs and vitamin D concentrations through electrophoresis and chemiluminescence methods, respectively. Diagnostic and staging tests were performed for all the dogs in the GL group, and included cytopathology, histopathology and immunohistochemistry of the affected lymph node. Of these dogs, 9 achieved a complete response and 4 a partial response to the treatment. Data analysis was performed with the R software. The results demonstrated that serum concentrations of IgA, haptoglobin and α1-acid glycoprotein were significantly different between the groups and also between the different chemotherapy times analyzed (p<0.05), indicating that these proteins can be considered as sensitive biomarkers for lymphoma in dogs. Furthermore, the α1-acid glycoprotein showed prognostic value for the disease, with 63% specificity. However, vitamin D concentration was not correlated with prognosis of the dogs with lymphoma.
Concentração de proteínas de fase aguda e vitamina D em cães com linfoma multicêntrico
Authors: Rocha Michelle do Carmo Pereira , Garnica Taismara Kustro , Fukumasu Heidge , Ramirez Ricardo Andres , Pazzini Josiane Morais , Sueiro Felipe Augusto Ruiz , Paiva Felipe Noleto de , Nardi Andrigo Barboza De
Published: September 2022

Resumo Objetivou-se caracterizar a concentração sérica da vitamina D e das PFAs (Proteínas de Fase Aguda) (alfa-1 glicoproteína ácida, haptoglobina, transferrina, ceruloplasmina, albumina, IgA, IgG e alfa-1 – antitripsina) em cães com linfoma multicêntrico, submetidos ao tratamento quimioterápico com protocolo CHOP (Ciclofosfamida, Doxorrubicina, Vincristina e Prednisona), determinando o valor prognóstico desses marcadores para a doença. Foram avaliadas as concentrações séricas das PFAs, através do método da eletroforese e as concentrações da vitamina D, através da quimioluminescência em dois grupos experimentais, um grupo de 13 cães com linfoma multicêntrico classificados como alto grau pela citologia (GL) durante as semanas T0, T5 e T10 do tratamento com protocolo quimioterápico antineoplásico e em um grupo de 10 animais saudáveis para compor o grupo controle (GC), em coleta única. Para isso, foi realizado o diagnóstico, estadiamento e avaliação de resposta terapêutica dos 13 pacientes com linfoma multicêntrico através de técnicas de citopatologia, histopatologia, imuno-histoquímica do linfonodo periférico acometido. Foi observado que 9 pacientes tiveram resposta completa e 4 pacientes tiveram resposta parcial ao tratamento. Os dados foram analisados através do software R. Os resultados indicam que as diferenças entre as variáveis IgA, haptoglobina e α1-glicoproteína ácida foram significativas entre os grupos, e entre os diferentes momentos da quimioterapia (p< 0,05), indicando que podem ser marcadores sensíveis ao linfoma em cães. A α1-glicoproteína ácida apresentou valor prognóstico para o linfoma, com 63% de especificidade. Porém a vitamina D não apresentou valor prognóstico para o linfoma multicêntrico em cães.
Comparison between the rebound (TD - 8000 portable) and applanation tonometer (Tono-Pen AviaTM) managed by different evaluators for intraocular pressure measurements in rabbits
Authors: Almeida Vinícius Thomaz da Silva , Garcia Cristiane Buzzato , Jorge Adriana Torrecilhas , Paulino Júnior Daniel , Martins João Guilherme , Pereira Poliana Marques , Almeida Júnior Silvio de , Dias Fernanda Gosuen Gonçalves
Published: September 2022

Abstract This study aimed to compare values of intraocular pressure (IOP) by different tonometers and evaluators (veterinary ophthalmologist specialist and veterinary not a specialist). For this, 30 rabbits were used, and in all (n = 60 eyes), the IOP was initially measured with a rebound tonometer (model TD - 8000 portable, Apramed Indústria e Comércio de Equipamentos Médicos Ltda) and, subsequently, with an applanation tonometer (portable model Tono-Pen AviaTM®, Reichert Technologies®, USA). With the two devices, the measurements in mmHg were performed in the central region of the corneas, always performed in the same period, by a professional veterinary ophthalmologist (specialist) and a professional veterinary (not a specialist). Data were statistically compared using the simple analysis of variance test. With the rebound tonometer, IOP ranged from 7 to 14 mmHg when measured by both evaluators; while with the applanation tonometer, from 9 to 15 mmHg by the specialist and from 8 to 16 mmHg by the non-specialist. In the right eyes, the IOP measured by the applanation tonometer by the non-experienced evaluator was statistically lower than the specialist's values; yet, the results of the two evaluators were higher in these same eyes when compared with those of the rebound tonometer. In the left eyes, the IOP measured by the applanation tonometer by the non-experienced evaluator was statistically higher than the specialist's values with the rebound tonometer. Thus, it was possible to infer that, regardless of experience in the area, the applanation tonometer indicated higher mean values of IOP in both eyes and, about the evaluators, the means of the measurements performed by the specialist were higher compared to the non-professional specialist.
Comparação entre o tonômetro de rebote (TD - 8000 portable) e aplanação (Tono-Pen AviaTM) manuseados por diferentes avaliadores para mensurações da pressão intraocular em coelhos
Authors: Almeida Vinícius Thomaz da Silva , Garcia Cristiane Buzzato , Jorge Adriana Torrecilhas , Paulino Júnior Daniel , Martins João Guilherme , Pereira Poliana Marques , Almeida Júnior Silvio de , Dias Fernanda Gosuen Gonçalves
Published: September 2022

Resumo Este estudo teve como objetivo comparar os valores da pressão intraocular (PIO) por diferentes tonômetros e avaliadores (veterinário oftalmologista especialista e veterinário não especialista). Para isso, foram utilizados 30 coelhos, em todos (n = 60 olhos), a PIO foi medida inicialmente com um tonômetro de rebote (model TD - 8000 portable, Apramed Indústria e Comércio de Equipamentos Médicos Ltda) e, posteriormente, com um tonômetro de aplanação (portable model Tono-Pen AviaTM®, Reichert Technologies®, USA). Com os dois aparelhos, as medidas em mmHg foram realizadas na região central das córneas, sempre no mesmo período, por um profissional oftalmologista veterinário (especialista) e um profissional veterinário (não especialista). Os dados foram comparados estatisticamente por meio do teste de análise de variância simples. Com o tonômetro de rebote, a PIO variou de 7 a 14 mmHg quando medida por ambos os avaliadores; enquanto com o tonômetro de aplanação, de 9 a 15 mmHg pelo especilista e de 8 a 16 mmHg pelo não especialista. Nos olhos direitos, a PIO medida pelo tonômetro de aplanação pelo avaliador não experiente foi estatisticamente inferior aos valores do especialista; ainda, os resultados dos dois avaliadores foram maiores nestes mesmos olhos quando comparados com os do tonômetro de rebote. Nos olhos esquerdos, a PIO medida pelo tonômetro de aplanação pelo avaliador não experiente foi estatisticamente superior aos valores do especialista com o tonômetro de rebote. Assim, foi possível inferir que, independente da experiência na área, o tonômetro de aplanação indicou maiores valores médios de PIO em ambos os olhos e, em relação aos avaliadores, as médias das medidas realizadas pelos especialistas foram maiores em relação ao não especialista.
ESTUDOS SOBRE O PROCESSO DE SÂNDI VOCÁLICO EXTERNO - DESTAQUE PARA A ELISÃO - NO PORTUGUÊS ARCAICO
Authors: CANGEMI Ana Carolina
Published: September 2022

Este estudo tem como objetivos principais o mapeamento e análise de processos de sândi vocálico externos nas cantigas religiosas portuguesas (Cantigas de Santa Maria) de Afonso X, o Sábio (século XIII). Os processos de sândi que ocorrem através da junção de palavras constituem elisão, ditongação, crase (MASSINI-CAGLIARI, 2005, para o português arcaico). Por meio deste trabalho e de um corpus não explorado (especialmente quanto aos temas linguísticos - SNOW, 1987; MASSINI-CAGLIARI, 2005), pretende-se contribuir para o alcance de um conhecimento mais profundo da história da prosódia portuguesa no período do seu reconhecimento como língua “independente” em relação ao latim.
Safety elements and understanding of guidelines at discharge from Neonatal Intensive Care Units
Authors: Pucca Bruna Gomes , Ribeiro Mara Regina Rosa , Acosta Aline Marques , Costa Diovane Ghignatti da , Milioni Kelly Cristina , Oliveira João Lucas Campos de
Published: September 2022

ABSTRACT Objective: To compare safety elements and the understanding of guidelines at discharge from the Neonatal Intensive Care Unit between public and private hospitals. Method: Cross-sectional study, developed in two Neonatal Intensive Care Units in the Midwest of Brazil. The Checklist for patient safety in preparing for discharge from the Neonatal Intensive Care Unit and the Assessment Scale of Patient Understanding about Discharge Guidelines were used for a sample (n=105) of caregivers of newborns. Descriptive and inferential statistical analysis was performed. Results: The Checklist item “skin care and body hygiene” had greater conformity in the private sector (96.9%) than in the public sector (73.2%) (p-value<0.000) and the understanding of discharge guidelines had an overall mean of 62.9±8.3 points, with no significant difference between the locations. Conclusion: Compliance with safety elements and understanding of guidelines at discharge were equal among hospitals.
Mycorrhizal effects on glomalin-related soil protein and chlorophyll contents in coffee plants in the Peruvian Amazon
Authors: Solis Reynaldo , Vallejos-Torres Geomar , Arévalo Luis , Caceres Benjamin
Published: September 2022

ABSTRACT The inoculation of vegetatively propagated coffee plants with arbuscular mycorrhizal fungi (AMF) prior to field establishment may positively influence the plant growth and physiology. This study aimed to evaluate the AMF effects on the glomalin-related soil protein and chlorophyll contents in vegetatively propagated coffee plants inoculated in a greenhouse and transplanted to an open field, in the Peruvian Amazon. The experiment consisted of eight treatments, in a 2 × 4 factorial design, being two coffee varieties (Caturra and Pache) and four AMF inocula (control, Moyobamba, El Dorado and Huallaga). The inocula were collected from organic coffee crops and named according to the province from which they were collected. The mycorrhizal colonization and chlorophyll content were statistically higher in the plants inoculated with AMF, if compared to the non-inoculated plants, while the glomalin-related soil protein content ranged from 61.6 to 69.1 mg g-1 and showed no statistically significant differences among the inocula, although the Moyobamba inoculum showed to be numerically superior. The effect of the coffee variety was not statistically significant among the variables under study.
Prediction of the natural distribution, habitat and conservation of Stryphnodendron pulcherrimum (Willd.) Hochr. in response to global climate change
Authors: Tomaz Jennifer Souza , Bezerra Caroline de Souza , Aguiar Ananda Virginia de , Wrege Marcos Silveira , Lopes Maria Teresa Gomes
Published: September 2022

ABSTRACT Stryphnodendron pulcherrimum is a species used medicinally among traditional Amazonian communities for its bactericidal activity and anti-inflammatory properties. Despite being adapted to rustic environments, there is no information regarding how climate change might affect the species occurrence. The present study aimed to evaluate the natural distribution of S. pulcherrimum in the current period and how its potential geographic distribution may be affected in response to future climate change scenarios in Brazilian phytogeographic domains. A total of 19 bioclimatic variables were used from the WorldClim database. Four algorithm models (Climate Space Model, Envelope Score, Niche Mosaic and Environmental Distance - present) and one software (Open Modeller - future) were used to verify the potential occurrence of S. pulcherrimum in five Brazilian domains (Amazon, Cerrado, Caatinga, Atlantic Forest and Pantanal) and three intervals (2009-2019 - present; 2020-2050 and 2051-2070 - future). There were losses of areas favorable to the occurrence of S. pulcherrimum in the Amazon, Cerrado and Pantanal, and global climate change may affect its natural distribution especially in the Atlantic Forest and Amazon. In the Amazon, the species may be totally extinct, in the worst scenario, by 2070.
Alteration of the organic matter fractions in soil cultivated with sugarcane in the Cerrado-Amazon transition zone
Authors: Ferreira Esvanio Édipo da Silva , Nascimento Elisamara Caldeira do , Silva Adeilson Nascimento da , Soares Keller Regina , Weber Oscarlina Lúcia dos Santos
Published: September 2022

ABSTRACT The use of agroindustrial wastes, such as vinasse, may alter the soil chemical and physical characteristics. This study aimed to evaluate the total organic carbon and total nitrogen in a soil and the distribution of carbon and nitrogen in the sand and clay granulometric fractions, in three management systems (with and without vinasse application and with burning for harvest, in comparison with primary/native forest coverage), regarding fertilization and harvesting of sugarcane, in the Midwest region of Brazil. The use of organic wastes in the sugarcane production system may promote, even in a short time frame, conservation and improvement of the soil quality by the addition and maintenance of organic carbon. The use of vinasse favors the increase of the total organic carbon and total nitrogen in the soil, in the clay fraction, at all evaluated depths. The system with burning results in lower total carbon levels in the sand fraction, in comparison with the clay fraction, and, even with the sugarcane harvest employing burning, the most recalcitrant organic matter is associated with the clay fraction.
Influence of irrigation, cladode size, harvest time and addition of citric acid on the properties of cactus mucilage
Authors: Oliveira Franquielle Ribeiro de , Fonseca Kelem Silva , Jardim Alexandre Maniçoba da Rosa Ferraz , Souza Jheizon Feitoza do Nascimento , Viégas Ellen Karine Diniz , Silva Anderson Rodrigo da , Simões Adriano do Nascimento
Published: September 2022

ABSTRACT Cactus is a highly resistant crop, and offers benefits in its mucilage for the industry due to its physicochemical properties. This study aimed to analyze the effect of irrigation managements, harvest time, cladode size and citric acid addition during the processing on the agro-industrial yield and physicochemical properties of mucilage extracted from cladodes of Nopalea cochenillifera Miúda clone cultivated under rainfied and irrigated conditions. The yield, soluble solids content, titratable acidity, pH, K+ and Na+ contents, and the electrical conductivity were measured in the mucilage. The management practices in the field resulted in changes in the studied phytochemicals. For the rainfied cultivation, the night harvest of the biggest cladodes increased the K+ and soluble solids contents. The addition of citric acid to the mucilage extraction resulted in higher amounts of soluble solids, titratable acidity and electrical conductivity and lower pH values. The highest water availability promoted higher mucilage yields.
Cidades inteligentes e sustentáveis: percepções sobre a cidade de Curitiba/PR a partir dos planos plurianuais de 2014 a 2021
Authors: Santos Évani Larisse dos , Franz Nádia Mara , Simão Angelo Guimarães , Ternoski Simão , Silva Christian Luiz da , Santos Gilson Ditzel
Published: September 2022

Resumo As opções de planejamento público das cidades materializadas nos Planos Plurianuais estão, muitas vezes, pautadas em brandings urbanos (rótulos) que nem sempre refletem as necessidades sociais e soluções de problemas, como a redução da vulnerabilidade. É preciso que as cidades, além de inteligentes, sejam sustentáveis e centradas nas pessoas. Nesta perspectiva o objetivo deste estudo é analisar se os Planos Plurianuais propostos pela Prefeitura Municipal de Curitiba/PR para o período de 2014 a 2021 refletem os conceitos adotados de smart city (cidades inteligentes) e de cidades sustentáveis. O estudo é exploratório e descritivo, com abordagem qualitativa, e se figura como estudo de caso da cidade de Curitiba/PR em que são analisados os planos plurianuais e sua relação aos rótulos de cidade inteligente e de cidade sustentável, refletindo em programas e projetos de alcance as necessidades sociais, econômicas e ambientais. Os resultados indicam que Curitiba nos PPAs analisados se aproximam mais do branding de cidade sustentável, sendo percebido em 89,47% dos programas, já o rótulo de smart city contempla apenas três dos 19 programas propostos no período avaliado.
Modelagem LUTI das decisões locacionais de diferentes grupos socioeconômicos: determinantes e inter-relações
Authors: Assis Rebeca Froés de , Loureiro Carlos Felipe Grangeiro , Sousa Francelino Franco Leite de Matos
Published: September 2022

Resumo Os modelos LUTI são reconhecidamente utilizados durante a formulação de políticas e intervenções de transportes e uso do solo. Em comparação aos modelos tradicionais de tráfego, eles buscam simular as decisões locacionais a partir de mudanças nos níveis de acessibilidade. Admite-se que lugares com maior acessibilidade se tornam mais atrativos, possuindo maiores chances de se desenvolverem em termos de ocupação. Na prática, essa dinâmica pode envolver diversos fenômenos, tais como segregação e fragmentação, devido às oscilações no valor do solo decorrentes de alterações no ambiente construído. Nessa perspectiva, entende-se que a adoção desses modelos em avaliações ex-ante deve revelar o desencadeamento de externalidades, sobretudo do ponto de vista social. Diante disso, este artigo se propõe a investigar até que ponto essas ferramentas representam e simulam as determinantes e as inter-relações das decisões locacionais de diferentes grupos socioeconômicos, de modo a permitir que as avaliações de intervenções em transportes revelem processos socioespaciais. Para tanto, buscou-se representar as decisões e as inter-relações mencionadas a partir de esforços de revisão bibliográfica (contribuições fenomenológicas conceituais). Na sequência, analisamos o modelo TRANUS com base nas representações desenvolvidas, concluindo que suas formulações matemáticas limitam a acreditação desse tipo de ferramenta analítica (contribuição metodológica).
Experiências de gravidez e puerpério de mulheres em hemodiálise: um estudo qualitativo
Authors: Faria-Schützer Débora Bicudo , Borovac-Pinheiro Anderson , Rodrigues Larissa , Surita Fernanda Garanhani
Published: September 2022

Resumo Introdução: Existem particularidades da doença renal crônica (DRC) em mulheres e seu tratamento. A biologia das mulheres as expõe a fatores de risco mais elevados para DRC e tanto a gravidez quanto o puerpério implicam um ônus adicional à saúde renal. Complicações na gestação podem causar ou piorar a DRC. Objetivo: Explorar as experiências de mulheres com DRC submetidas à hemodiálise em relação ao seu histórico reprodutivo. Métodos: Este estudo consistiu em desenho clínico-qualitativo com entrevistas individuais semiestruturadas e questões abertas. A seleção da amostra foi intencional e de acordo com o critério de saturação teórica. A análise de dados foi realizada com base nos sete passos da análise clínico-qualitativa de conteúdo e validada pelo Nvivo11. Este estudo foi realizado em uma clínica pública de hemodiálise do Sistema Único de Saúde brasileiro. Resultados: Foram entrevistadas 12 mulheres em hemodiálise. Os resultados da análise revelaram três categorias: 1) Associação da gravidez com DRC; 2) Nebulosidade em relação ao diagnóstico e à história reprodutiva; 3) Ser mulher e fazer hemodiálise. Conclusões: Nosso estudo mostrou a importância de considerar as especificidades da DRC em mulheres, sugerindo que estas questões são importantes para o diagnóstico e a adesão ao tratamento. A consideração do histórico de vida reprodutiva permite promover de forma holística a saúde das mulheres submetidas à hemodiálise, incluindo aspectos de saúde mental.
Conhecimento da população sobre a doença renal crônica, seus fatores de risco e meios de prevenção: um estudo de base populacional em Fortaleza, Ceará, Brasil
Authors: Albuquerque Ana Carolina Rattacaso Marino de Mattos , Pinto Gustavo Neves , Pereira Gabriel Araújo , Silva Luísa Falcão , Fontenele Thaís Azevedo Souza , Oliveira Juliana Gomes Ramalho de , Silva Junior Geraldo Bezerra da
Published: September 2022

Resumo Introdução: A doença renal crônica (DRC) vem aumentando de forma significativa. Há evidências de que grande parte da população não tem conhecimento suficiente sobre o assunto. Objetivo: Investigar na população geral o nível de conhecimento sobre a DRC, seus fatores de risco e meios de prevenção. Métodos: Foi realizado estudo transversal na população de Fortaleza, Ceará, Brasil, entre 2017 e 2020, com aplicação de um questionário sobre DRC, fatores de risco e prevenção. Resultados: Foram entrevistados 735 voluntários, com média de idade de 38 anos, dos quais 55% eram do sexo feminino. Apenas 17,2% responderam corretamente ao conceito de DRC, e 5,8% sabiam o conceito de creatinina. A baixa ingestão hídrica foi o fator de risco mais citado pelos entrevistados (79,3%). Os principais fatores de risco e as causas diretas de DRC (diabetes e hipertensão) foram mencionados com menor frequência (13,2% e 15,1%, respectivamente). Os homens tiveram maior acerto com relação aos fatores de risco e às formas de prevenção da DRC. Os entrevistados com idade mais avançada responderam mais corretamente às perguntas sobre a definição de DRC (n = 22; 28,6%) e creatinina (n = 7; 9,0%). No que diz respeito à escolaridade, em todas as perguntas houve correlação estatisticamente significativa (p < 0,05). Conclusão: Há um baixo nível de conhecimento sobre a DRC na população geral. Maior nível de escolaridade associa-se a um melhor conhecimento. São necessárias mais ações de educação em saúde para que a população conheça melhor a DRC e consequentemente possa adotar medidas de prevenção e controle mais adequadas.
Desfechos de crianças com síndrome nefrótica idiopática córtico-resistente: um estudo observacional de centro único
Authors: Mishra Om P. , Sidar Minketan , Batra Vineeta V. , Prasad Rajniti , Singh Ankur , Abhinay Abhishek , Mishra Akash , Yadav Ashish K.
Published: September 2022

RESUMO Introdução: A síndrome nefrótica idiopática córtico-resistente (SNICR) apresenta desfechos variáveis em crianças. O objetivo principal deste estudo foi avaliar a taxa de remissão cumulativa. Os objetivos secundários foram avaliar fatores que afetam status de remissão, sobrevida da função renal e efeitos adversos de medicamentos. Métodos: Foram incluídos 114 pacientes com SNCR. Utilizou-se protocolo de tratamento baseado em inibidores de calcineurina juntamente com prednisolona e inibidor da enzima conversora de angiotensina. Os pacientes foram acompanhados durante 5 anos. Resultados: A idade mediana foi 4,5 anos; 53,5% dos casos tinham entre 1 e 5 anos. 62 pacientes (54,4%) estavam em estágio inicial; 52 (45,6%) em estágio tardio da SNCR. A TFGecr mediana foi 83,5 mL/min/1,73 m2 na apresentação. Dos 110 pacientes, 63 (57,3%) alcançaram remissão [remissão completa 30 (27,3%), remissão parcial 33 (30%)], e 47 (42,7%) não apresentaram remissão. A sobrevida da função renal foi 87,3%; 14 casos (12,7%) progrediram para DRC (G3-8, G4-3, G5-1, G5D-2). A duração mediana do acompanhamento foi 36 meses (IIQ 24, 60). Idade no início, ciclosporina/tacrolimus, TFGecr e histopatologia (DLM/GESF) não afetaram a remissão. Igualmente, status de remissão, além da idade no início, protocolo de medicamentos e histopatologia não afetaram significativamente a função renal por 5 anos. Observou-se hipertensão, fácies cushingoide, baixa estatura, catarata e obesidade em 37,7; 29,8; 25,5; 17,5; e 0,7% dos casos, respectivamente. Conclusão: Aproximadamente metade dos casos alcançou remissão. Idade no início, uso de ciclosporina/tacrolimus e lesão histopatológica não afetaram o status de remissão nem a sobrevida da função renal a curto prazo na SNICR.
Preemptive kidney transplantation: why, when, and how?
Authors: Moura Ana Flávia , Moura-Neto José A. , Requião-Moura Lucio R. , Pacheco-Silva Álvaro
Published: September 2022

ABSTRACT Among renal replacement therapies, preemptive kidney transplantation (PKT) presents the best clinical, social, and economic results. However, it is still infrequently chosen as first therapy for patients with irreversible kidney failure. Initiatives in different parts of the world were developed to identify the reasons why PKT is still not widely used and to facilitate the access of patients with end-stage kidney disease to the advantages associated with it. This article addresses the main advantages and difficulties of PKT and discusses when it should be indicated and how to prepare potential recipients for PKT.
Transplante renal preemptivo: por que, quando e como?
Authors: Moura Ana Flávia , Moura-Neto José A. , Requião-Moura Lucio R. , Pacheco-Silva Álvaro
Published: September 2022

Resumo Entre as terapias renais substitutivas, o transplante renal preemptivo (TRP) apresenta os melhores resultados clínicos, sociais e econômicos. No entanto, ainda é raramente escolhido como primeira terapia para pacientes com falência renal irreversível. Foram desenvolvidas iniciativas em diferentes partes do mundo para identificar as razões pelas quais o TRP ainda não é amplamente utilizado e para facilitar o acesso de pacientes com doença renal em estágio terminal às vantagens associadas ao mesmo. Este artigo aborda as principais vantagens e dificuldades do TRP e discute quando ele deve ser indicado e como preparar potenciais receptores para o TRP.
Performance and carcass and meat quality of crossbred sheep confined with and without access to artificial shade
Authors: FERRO Diogo Alves da Costa , AQUINO Lídia Mendes de , FERRO Rafael Alves da Costa , SILVA Bruna Paula Alves da , SANTOS Klayto José Gonçalves dos , SANTOS Aracele Pinheiro Pales dos , BUENO Claúdia Peixoto , PAULA Raiany Soares de
Published: September 2022

ABSTRACT The aim of this study was to evaluate the performance and carcass and meat quality of sheep in an intensive production system with and without artificial shade available. Twenty Santa Inês × Dorper crossbred lambs were allotted to two collective stalls, one of which was covered with a black polypropylene shade net with 80% light interception, providing 2.5 m2 shade animal-1. Performance was evaluated by measuring initial weight, final weight, carcass yield, average daily weight gain, and total weight gain. Carcass and meat traits were evaluated based on the variables of fatness, conformation, loin-eye area, subcutaneous fat thickness, marbling, texture, pH, temperature, and color. Performance and carcass and meat traits were similar between the animals reared in stalls with and without shade available. The groups with and without access to shade showed initial weights of 26.52 and 25.37 kg, final weights of 35.59 and 34.76 kg, carcass yields of 45.73 and 45.50%, loin-eye areas of 14 .11 and 13.61 cm2, and marbling scores of 4.78 and 4.44, respectively. Subcutaneous fat thickness (2.02 cm), texture (3.67), and fatness (2) values were equal for both groups. Based on the results, artificial shading did not affect the performance or carcass and meat quality of the sheep.
Optimization of blueberry flour processing and anthocyanin extraction
Authors: Biasi Vanessa , Huber Eduardo , Barreto Pedro Luiz Manique
Published: September 2022

Abstract The objective of this work was to determine the ideal conditions for the processing of flour and extraction of anthocyanins from blueberries (Vaccinium corymbosum). A central composite design (CCD) with response surfaces was used. For the processing of blueberry flour, different dehydration temperatures (53ºC-67ºC) and times (43.18-48.82 hours) were used. The extraction of anthocyanins was performed with ethanol solutions (15-85% v/v) at different pH values (1.0-4.0). ). The total monomeric anthocyanin content was 1,538.39±25.63 mg 100 g-1 (0.89 desirability value) for fresh blueberries in the optimal extraction condition (53.5% ethanol, 2.5 pH) and 3,101.04±11.57 mg 100 g-1 (0.96 desirability value) for blueberry flour in the optimum processing condition (53ºC, 46 hours). The optimized extraction and dehydration of blueberries provide high levels of anthocyanins in the samples.
Resistance of common bean lines to Sclerotinia sclerotiorum isolates under different environmental conditions
Authors: Abreu Mariana Junqueira de , Leite Monik Evelin , Ferreira Alex Naves , Pereira Rafael , Pereira Fernanda Aparecida Castro , Souza Elaine Aparecida de
Published: September 2022

Abstract The objective of this work was to evaluate the reaction of common bean (Phaseolus vulgaris) lines to Sclerotinia sclerotiorum, the aggressiveness of the isolates, and the inheritance of resistance to white mold, under two environmental conditions. The experiments were carried out under field and greenhouse conditions. In each one, four isolates were inoculated in 14 common bean lines using the straw-test inoculation method and severity on plants. No common bean line with a high level of resistance to white mold was identified, and most of the lines were moderately resistant to the pathogen. In general, the BRS Campeiro, BRS Radiante, BRSMG Talismã, and Ouro Negro cultivars stand out for resistance. Under field conditions, the UFLA 3 isolate discriminates well the lines, while, under greenhouse conditions, UFLA 26 and UFLA 92 are the most aggressive isolates. Furthermore, according to the genetic study, most of the observed variation can be attributed to horizontal resistance, although a small part is associated with vertical resistance.
Digital imaging outperforms traditional scoring methods for spittlebug tolerance in Urochloa humidicola hybrids
Authors: Hernández Luis , Espitia Paula , Cardoso Juan Andrés
Published: September 2022

American spittlebug species (Hemiptera: Cercopidae) are major pests in Urochloa humidicola (syn. Brachiaria humidicola) cultivars in the neotropics. The U. humidicola breeding program of the Alliance Bioversity-CIAT aims to increase tolerance to spittlebugs. To develop tolerant U. humidicola genotypes, adequate screening methods are needed. Currently, visual scores of plant damage by spittlebugs is the standard method to screen for variation in plant tolerance. However, visual scoring is prone to human bias, is of medium throughput and relies on the expertise of well-trained personnel. In this study, estimations of plant damage from SPAD measurements and digital images with visual scoring from an inexpert evaluator and visual scoring from an expert were compared. This information should inform if different methods could be implemented in the U. humidicola breeding program. Time needed to evaluate damage was recorded for each method. Lin’s correlation coefficient, Pearson’s correlation coefficient and broad sense heritability values were calculated. Damage estimated from digital images showed the highest throughput (twice as fast as visual scoring from an expert), high correlations with visual scoring (r>0.80, P<0.0001) and heritability values for plant damage as good or better (>0.7) than those obtained by visual scoring from an expert. Results indicate that digital imaging could improve the efficiency of phenotyping in breeding for increased tolerance to spittlebugs in U. humidicola.
Yörüklerde Müzik ve Boğaz Çalma
Authors: ERGUN Levent
Published: September 2022

Yörükler bugün ağırlıklı olarak Anadolu’nun Güneybatı bölgesinde yerleşik olarak yaşam sürmektedir. Osmanlı İmparatorluğu döneminde geleneksel yaşam biçimleri olan göçebe hayvancılık yaparak yaşayan Yörüklerin uygulanan iskân politikaları ve ekonomik koşullar yüzünden giderek yerleşik yaşama geçtikleri ancak bazı toplulukların göçebe ve yarı göçebe yaşam tarzını sürdürdükleri görülür. Günümüzde Yörüklerin neredeyse tamamı yerleşik olarak yaşamakla birlikte oldukça az sayıdaki Yörük yarı göçebe ve göçebe olarak hayvancılık yapmaktadır. Yörüklerin, toplumsal örgütlenme biçimleri dünya üzerindeki diğer pastoral yaşam süren topluluklara benzer biçimde aşiretler ve soy grupları biçiminde düzenlenir. Bununla birlikte kendilerini tanımlamada üyesi oldukları aşiret, oba ya da soy grubunu özellikle vurgularlar.
Göçebe yaşam ve hayvancılığın etkileri Yörük müziğinde de kendini gösterir. Yörüklerin kullandığı kaval, düdük, sipsi, kemane ve üç telli gibi çalgılar küçük, hafif ve kolay taşınabilirdir ve söz konusu çalgılarla icra edilen repertuvarları da yine yaşam biçimleri ve hayvancılığa uygunluk gösterir. Sözgelimi yayık soğudan, çömlek kırdıran ve Karakoyun efsanesi gibi bu yaşama ilişkin öyküleri bulunan parçalar bunlar arasında sayılabilir. Erkek koyun çobanları hayvanlara ilişkin bir repertuvarı genellikle kaval ve düdük gibi üfleme çalgılarla hayvanların yakınında seslendirir. Genç kız ve kadınlar tarafından farklı bağlamlarda icra edilen vokal boğaz çalma pratiğinde seslendirenin bağlı olduğu aşiret, soy grubu ve obayı temsil eden tek bir ezgi söz konusudur. Aynı topluluk içinde değişik sözlerle seslendirilen ve farklı havalar olarak algılanan parçalar yine topluluğa ait aynı ezgi ile seslendirilir. Bazı parçaların sözleri bir başka Yörük topluğu tarafından olduğu gibi kullanılabilir ancak ezgi kendilerine ait olan boğaz ezgisidir. Yani boğaz çalma pratiğinin görüldüğü her topluluğun kendine özgü bir ezgisi vardır. Bu durum Yörüklerin kendilerini tanımlamada öne çıkardıkları etnik kimliği vurgulamanın müziksel bir yoludur. Bu makale 1995-2002 yılları arasında Antalya, Isparta, Burdur, Mersin, Adana, Konya, Karaman, Denizli, Manisa, İzmir ve Sakarya’da Yörüklerle yapılan alan çalışmasında gözlem ve görüşme yoluyla elde edilen verilere dayanır.
Effects of Expressive Writing through Self-Distancing on Emotion and Pain Outcomes in Individuals Who Use Emotional Suppression
Authors: Lee Soojin , Cho Sungkun
Published: September 2022

Background: Emotions are closely related to pain outcomes, and maladaptive emotional regulation strategies such as suppression can exacerbate pain. The purpose of this study was to empirically investigate the effects of expressive writing on emotions and pain outcomes of individuals who use emotional suppression.Methods: Forty university students with an emotional suppression scale score of more than one standard deviation participated in this study. There were 20 students in the expressive writing group and 20 students in the control group. For the expressive writing group, emotions (negative emotions and state anxiety) and pain experiences (threshold, tolerance, intensity, and pupil diameter measured during cold pressure tasks) were assessed before and after a writing intervention.Results: The expressive writing group had lower post-negative affect than pre-negative affect and lower post-state anxiety than the control group. However, there were no significant differences between groups in pain outcomes and self-distancing.Conclusions: These findings suggest that expressive writing can help individuals express and experience negative emotions and anxiety more healthily.
Aktas—an “Ephemeral” Upper Paleolithic Site in North Kazakhstan
Authors:   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Anoikin A. A. ,   Altai State University, Klementiev A. M. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences,   Institute of the Earth’s Crust, Siberian Branch, Russian Academy of Sciences, Zotkina L. V. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences,   ZooSCAn International Research Laboratory, CNRS – IAET SB RAS, IRL 2013, Kurbanov R. N. ,   Lomonosov Moscow State University,   Institute of Geography, Russian Academy of Sciences, Kharevich V. M. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Bocharova E. N. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Taimagambetov Z. K. ,   National Museum of the Republic of Kazakhstan
Published: September 2022

В статье представлены данные, полученные на новом этапе исследований верхнепалеолитической стоянки Актас, первые работы на которой были проведены в 1982-1983 гг. Памятник расположен в Северном Казахстане, где палеолитические объекты очень редки. В работе приводятся материалы по стратиграфии, палеонтологии, археологии и хронологии стоянки. На памятнике выделены шесть литологических слоев, два из которых (3 и 4) содержат многочисленные фаунистические остатки. Хронология объекта построена на серии ОСЛ-дат. Установлено, что накопление слоя 2 происходило в интервале ~20-12 тыс. л.н., слои 3 и 4 формировались ~50-30 тыс. л.н. На памятнике найдено изделие из камня — скребло из «импортного» кремня. Основу ископаемого фаунистического комплекса составляют копытные — плейстоценовая лошадь Equus ferus, шерстистый носорог Coelodonta antiquitatis и горный баран Ovis ammon. Часть костных остатков несет следы преднамеренной фрагментации и разделки с помощью каменных орудий. С учетом этого, а также особенностей тафоценоза (видовой состав, отсутствие следов деятельности хищников и др.), расположения и стратиграфии стоянки сделан вывод о том, что данное скопление палеофауны могло сформироваться только в результате антропогенной деятельности. Единичные свидетельства пребывания человека позволяют рассматривать Актас только как «эфемерную» стоянку, фиксирующую заселение данной территории в позднеплейстоценовое время, без каких-либо культурных определений. Материалы памятника соответствуют стоянкам типа kill-site — местам разделки и потребления охотничьей добычи. На данный момент это единственная стоянка подобного типа в исследуемом регионе. Малочисленность каменных артефактов не позволяет определить культурную принадлежность ее материалов. Однако возраст памятника свидетельствует о том, что северные районы Казахстана были заселены уже в начале МИС3, что соответствует начальным этапам верхнего палеолита.
Classic Samarra Painted Pottery from Yarim Tepe I, the Neolithic of Northern Iraq
Authors:   Institute of Archaeology, Russian Academy of Sciences, Petrova N. Y.
Published: September 2022

В статье рассматривается классическая самаррская расписная керамика из слоя Стандартной Хассуны поселения Ярым-тепе I (Северный Ирак). Выявлены две группы импортных изделий. Первая представлена материалами Классической Самарры, связанными, вероятнее всего, с Центральной Месопотамией, вторая — импортами самаррской керамики, имеющими западное происхождение. Предполагается, что самаррская керамика служила предметом импорта не только в направлении из центра в различные части периферии, но и из одной части периферии в другую. Рассматривается гипотеза о формировании самаррской общности периода Классической Самарры на основе симбиоза двух более ранних культурных традиций — периода Протохассуны в Северной Месопотамии и неолитических традиций, связанных по происхождению с центральной частью Загроса.
Chinese Coins from the Early Medieval Cemetery Gorny-10, Northern Altai
Authors:   Altai State University, Seregin N. N. , Tishin V. V. ,   Institute for Mongolian, Buddhist and Tibetan Studies, Siberian Branch, Russian Academy of Sciences, Stepanova N. F. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences
Published: September 2022

В статье представлены результаты изучения представительной серии китайских монет, обнаруженных в ходе раскопок погребений некрополя Горный-10. Данный памятник, расположенный на Северном Алтае, исследовался экспедициями Алтайского государственного университета в 2000-2003 гг. Монеты найдены в восьми объектах (мог. 6, 18, 44-46, 48, 62, 66). Публикуемая коллекция, уникальная для археологических комплексов Северной и Центральной Азии с точки зрения состава и разнообразия изделий, насчитывает 29 экз., относящихся к различным группам. Наряду с довольно распространенными за пределами Китая монетами у-чжу и кай-юань тун-бао обнаружены весьма редкие — чан-пин у-чжу и у-синь да-бу. Нумизматическая характеристика находок позволила сделать ряд заключений о датировке отдельных объектов и всего памятника. Нижняя дата сооружения большинства захоронений (мог. 6, 45, 46, 48, 62, 66) не может быть ранее 581 г., о чем свидетельствует обнаружение суйских монет у-чжу. Погребения 18 и 44, в которых найдены экземпляры кай-юань тун-бао, совершены позже 30-х гг. VII в. н.э. С учетом имеющихся дополнительных данных (отсутствие поздних выпусков кай-юань тун-бао, результаты радиоуглеродного анализа) объекты некрополя Горный-10 датируются концом VI — VII в. н.э. Установлено, что монеты обнаружены только в женских и детских погребениях памятника. Судя по зафиксированному расположению, рассматриваемые изделия являлись частью комплекса украшений головы, были элементами декора пояса, а также использовались в качестве подвесок и амулетов.
In vitro Evaluation of Antigenotoxic Effects of Phloridzin
Authors: SARİMAHMUT Mehmet , VEKSHARİ Sindi , DEMİRBAG KARAALİ Merve , CELİKLER Serap
Published: September 2022

Phytochemicals have a vast number of properties contributing to human health by acting on numerous different mechanisms. Phloridzin, a phytochemical mainly found in Malus species, possesses diverse biological activities including anti-diabetic and antioxidative activities. Here, our aim is to explore antigenotoxic potential and proliferative effects of phloridzin on human lymphocytes in vitro by employing chromosome aberration, micronucleus and comet assays. Mitomycin C, both an anticancer and genotoxic agent, was utilized to induce genotoxicity. Phloridzin significantly suppressed the genotoxic effects of mitomycin C at 125-500 µg/mL concentrations in all assays used (p < 0.05). We also revealed that phloridzin and mitomycin C combination had a significantly negative effect on mitotic index (p < 0.05), whereas in general, gender differences did not play a role in manifestation of neither antigenotoxic nor antiproliferative activities of the combination.These results suggest that phloridzin is an antigenotoxic compound and its consumption may interfere with the activity of anticancer drugs that exert their effects based on genotoxic mechanisms.
Chemical and Radiological Characterizations of the Desert Dust Coming from Northern Africa to Batman (Southeastern Turkey)
Authors: IŞIK Ümit , ÇEVİK Uğur , BAL AKKOCA Dicle , OĞUZ Kahraman , DAMLA Nevzat
Published: September 2022

This work investigates the chemical and radiological characterizations of the dust coming from Sahara in North Africa to Batman city in the southeastern region of Turkey on 20 May 2017. According to meteorological maps, the source region of the dust storm that took place in Batman was found to be Libya, which is supported by the NOAA HYSPLIT model’s back trajectory analysis. XRD analyses show that the common minerals of the dust samples are quartz, feldspars, calcite, dolomite, hematite and rutile. Chemical patterns of some major, minor and trace elements in dust samples are generally consistent with those of Saharan Dust composition. The heavy metals in the dust follow the decreasing concentration order: Mn > Zn > Cr >Ni > Cu > Pb. The enrichment factors (EF) of these elements show anthropogenic contamination effects with regard to Zn, Cr and S elements in dust samples. The corresponding values of the radionuclides, the absorbed dose rates in the air and the annual effective doses in the samples were also evaluated and compared to the internationally recommended values. The findings are supposed to be beneficial for tracking and evaluating any environmental pollution inventory in this area.
Some Heterocyclic Hydrazone Compounds: Synthesis, Spectral Characterization and Anticancer Activity Study
Authors: BAŞARAN Eyüp , ÇAKMAK Reşit , ÇINAR Ercan , CEVİK Ozge
Published: September 2022

Cancer is currently ongoing to be a significant health problem threatening human health. Hydrazone compounds constitute a popular class of organic compounds used in novel drug discovery studies in therapy of cancer. In the current study, the preparation and structural characterization of some heterocyclic hydrazone compounds (7-12) and their anticancer capacities against HeLa cervical cancer and MCF-7 breast cancer cell lines were reported. The target compounds were characterized by some spectroscopic techniques (1H NMR, 13C NMR and FT-IR). The in vitro cytotoxic potentials of the target molecules were assessed by using MTT assay against two cancer cell lines. L929 mouse fibroblast cell lines were employed as normal cell. The results displayed that some of the tested molecules had varying anticancer activities. Among the tested compounds, compound 8 indicated anticancer activity against HeLa cells with IC50 value of 34.38 µM. On the other hand, of these tested compounds, compound 11 (IC50 = 26.84 µM) displayed anticancer activity against MCF-7 cells.
Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds
Authors: COŞKUN Göknil , AKLAMUZ Akın , İNCE Ufuk , ÜLGEN Mert
Published: September 2022

Bacterial infection today occupies a tremendous place in world health. The infection diseases were kept under control after the development of penicillin and further studies were performed on the development of new antibacterial agents. However, to date, bacterial resistance caused a big failure in the treatment of infectious disease and therefore, development of new antibacterial agents became important for human health. In the present study, we have designed, synthesized and elucidated the structures of new hydrazide-hydrazone compounds and their hybrid amide derivatives. The structures of the compounds were elucidated with spectroscopic methods and their purity were proven by TLC, HPLC-MS analysis. The antibacterial and antifungal activity studies of the novel molecules were investigated on different strains. Among the synthesized compounds, AA3a and AA4a appeared to show promising antibacterial activity. None of the compounds showed significant antifungal activity on Candida albicans. The drug likeness properties and boiled-egg plot analysis were performed for all of the compounds. The novel molecules showed no violation on Lipinski’s rule of five and all the molecules showed good gastrointestinal absorption properties in the in silico studies.
Generalization of Some Integral Inequalities for Arithmetic Harmonically Convex Functions
Authors: KADAKAL Huriye
Published: September 2022

In this study, by using an integral identity, Hölder integral inequality and modulus properties we obtain some new general inequalities of the Hermite-Hadamard and Bullen type for functions whose derivatives in absolute value at certain power are arithmetically harmonically (AH) convex. In the last part of the article, applications including arithmetic mean, geometric mean, harmonic mean, logarithmic mean and p-logarithmic mean, which are some special means of real numbers, are given by using arithmetic harmonically convex functions.