bluuebunny/crossref_metadata_2025 huggingface dataset:
Internalizing Nationalism Awareness in Early Childhood Islamic Education Institution with The Spirit of Aswaja an-Nahdliyah
Authors: Istiyani Dwi , Wibowo A.M.
Published: December 2020

This study aims at describing and analyzing the internalization of national awareness through raudlotul athfal (RA; an Islamic early childhood education institution) with the spirit of Aswaja an-Nahdliyah. Aswaja an-Nahdliyah is an ideology adopted by Nahdlatul Ulama, a major Islamic religious organization in Indonesia. This study argues that the internalization of the national awareness needs to be instilled from early age to anticipate the inﬂuence of globalization which is feared to erode the original character of a nation. Within the study, the qualitative method was adopted in order to answer two research questions: (1) how Islamic early childhood educational institutions develop nationalism awareness through the teachings of Ahlusunnah wal Jamaah; and (2) how the institutions construct the awareness of nationalism through the teachings of Ahlusunnah wal Jamaah. The results of the study show that the internalization of nationalism awareness through Islamic early childhood education institutions with the Aswaja an-Nahdliyah’s spirit has been carried out through curriculum content which has been systematically arranged in each research subject with the principle of considering early childhood characteristics. At the same time, the results of the study also show that the construction of nationalism awareness in the Islamic early childhood education institutions can be seen in Islamic holidays and national activities which were held on the Islamic early childhood institutions.
Rereading the Concept of Nusyūz in Islamic Marriage Law with Qira'ah Mubādalah
Authors: Nisa' Khoirotin , Muslih Muslih , Hapsin Abu
Published: December 2020

Islam exists in order to uphold justice. Likewise with families, where there are often unfair relationships between husband and wife, there are so many obstacles which can threaten the harmony of marriage. So far the issue of nusyūz is often connected to the wife and the Compilation of Islamic Law (KHI) conﬁrms this. How Islamic law regulates nusyūz and how the perspective of qira'ah mubādalah about this nusyūz is are the main questions of this study. This study uses normative legal research method with descriptive technique. Data collection was carried out by literary study and then they were analyzed qualitatively by the deductive method. The results of this study are as follow: Nusyūz according to Islamic law (KHI) is conceptualized as a wife's disobedience to her husband, such as reluctance to have intercourse, surly in front of her husband, leaving the house without the husband's permission and others which make the husband dislike. If nusyūz occurs then it is resolved by: giving advice, separating beds, and hitting. Mubādalah as a method of interpretation of texts which is reciprocal, in terms of family relations between husband and wife, deﬁnes nusyūz as disobedience to household commitments so it applies to husband and wife. Nusyūz settlement by beating is considered as an act of violence so it should not be done. Inviting reconciliation to return to commitment is the best way according to QS. An Nisa': 128.
CLINICAL ASSESSMENT OF URINATION IN YOUNG CHILDREN
Authors: Deryugina L. A. , Otpuschennikova T. V.
Published: December 2020

The aim of the study was to study the formation of urination in young children, taking into account perinatal factors. Material and methods. the pattern of urination was studied in 42 patients at the stages of antenatal observation, after birth during the first year of life and at the age of three. Clinical evaluation of urination was performed in young children using a developed qualimetric table that takes into account the volume of the bladder and frequency of urination, the nature of urination, the presence of urge to urinate and behavioral reactions. At the age of three, a qualimetric table was used to evaluate E. L. Vishnevsky’s urination (2001). The observation group consisted of 42 patients whose urination pattern was studied at the stages of antenatal observation, during the first year of life and at the age of three. The features of the course of the antenatal and postnatal period of children’s development were taken into account: pregnancy complications, fetal pathological conditions, features of the morpho-functional state of infants, and neurological comorbidities. Results. According to the results of clinical evaluation of urination in children at 3 years of age, 3 groups of children were identified: with “Mature”,”delayed formation of “Mature” type of urination”, as well as “dysfunctional type of urination”. Conclusions. the manifestations of “maturity of urination” in infants at the age of 1 year are the compliance of hydrodynamic indicators with age standards, the formation of continuous urination, signs of controlling behavior: behavioral reaction to the urge, the absence of” missing urine “during the day, during daytime and nighttime sleep, “urination on request”. The “delay in the formation of mature urination type”, the formation of “dysfunctional urination type “ revealed the determining influence of the pathological course of the antenatal period of child development, the implementation of signs of pathological fetal urination, the presence of neurological symptoms and signs of morpho-functional immaturity of the postnatal period. “Dysfunctional urination” was manifested by: a decrease in the capacity of the bladder and the discrepancy between the hydrodynamic characteristics of the age parameters; monotony of the volume characteristics of the bladder during the day; imperative contractions of the bladder, that is, the presence of “wet gaps” between urination; urination during sleep; as well as a delay or lack of urge to urinate, behavioral responses and neatness skills.
PECULIARITIES OF SURGICAL TREATMENT OF LUMBOSACRAL DISC HERNIATION
Authors: Gornaeva L. S. , Rumyantseva G. N.
Published: December 2020

Introduction. In pediatric practice, herniated discs that require surgical treatment are quite rare (0.5% of all surgical interventions for degenerative spinal diseases). At the same time, there is a tendency to the increase in the number of diagnosed intervertebral disc extrusions in adolescents. Despite of good effectiveness of the standard microdiscectomy, new techniques for removing a herniated disc are being developed to improve results in the postoperative period. Material and methods. The paper presents outcomes of surgical treatment of 59 patients with herniated discs, including 22 children. A comparative characteristics of two techniques was made: traditional microdiscectomy where a hernial component is removed and advanced microdiscectomy where an additional foraminotomy is made under the control of endoscopic technique. The discussed modified surgical treatment was patented (patent for invention No. 2687020 dated 06.05.2019). The authors have compared the effectiveness of these techniques at immediate and long-term periods in all operated patients. Rezults. The number of excellent and good results for the proposed method was higher than 95%, than for the traditional method - 88,9% . Conclusion. The proposed technique improves outcomes of surgical treatment of a herniated disc by eliminating compression of the spinal nerve root in the initially narrow foraminal opening and by expanding the latter under the control of endoscopy with a minimal risk of postoperative complications.
CRITERIA OF EFFICIENCY OF INGUINAL HERNIOTOMY IN CHILDREN UNDER VARIOUS TECHNIQUES
Authors: Stolyar A. V. , Aksel'rov M. A. , Mal'chevskiy V. A.
Published: December 2020

Purpose. To improve outcomes of congenital inguinal hernia treatment in children by improving a technique of extracorporal herniorrhaphy and by ligature guide modification. Outcomes after surgeries performed with different techniques were assessed by the level of postoperative pain and by the quality of life. Material and methods. Outcomes were analyzed in 60 children operated on for inguinal hernia with 3 different approaches: Duhamel, LASSO, LOD . The intensity of postoperative pain syndrome was assessed 4 hours after surgery and on the next postoperative day. The quality of life was assessed in 24 patients out of 60 on the next postoperative day. Results. The analysis on distribution to normality for postoperative pain did not reveal any statistical differences on sex, age and diagnosis. Boys (average age 69.6 - 84 months) prevailed. In 4 hours after the surgery, patients who had laparoscopic intervention had less number of scores in comparison to those who had open herniorrhaphy. There were no difference in laparoscopic groups. On the next postoperative day, pain syndrome in all groups was about the same. The quality of life in patients differed only by their physical status and by the total number of scores; and these parameters were higher in LOD group (32.8 scores versus 89.4 scores). Conclusion. A modified LOD technique improves the quality of life in operated patients. Four hours after laparoscopic herniorrhaphy, a pain syndrome is less pronounced.
POTENTIALS FOR VIDEO-ENDOSCOPIC REMOVAL OF LYMPHANGIOMAS OF THE SOFT TISSUES IN NEWBORNS
Authors: Nurmeev I. N. , Zikova M. A. , Mirolubov L. M. , Podshivalin A. A.
Published: December 2020

Introduction. Lymphangiomas (lymphatic malformations) are benign vascular formations that develop from the lymphatic vessels and locate at the intermediate position between tumor and malformation [1,2,3]. The lack of unified algorithm in the treatment of lymphangiomas and a variety of operative and conservative techniques used with a high percentage of relapses leave the problem of treating lymphangiomas open. Material and methods. This article demonstrates outcomes of surgical treatment of lymphangiomas in soft tissues in newborns after they were treated with a technique developed and patented by the authors (Patent No 2711257 dated 15.01.2020*). The technique for treating lymphangiomas with video endoscopic component allows to simultaneously and radically remove tumors in children (including newborns) with minimally invasive approach. 10 surgical interventions were performed with the discussed technique. Results. In all cases the result was a complete radical simultaneous removal of soft tissue lymphangiomas under video control. The proposed curative technique is considered to be the most reasonable one due to its radical nature and good cosmetic effect when removing superficially located lymphangiomas. Discussion. A persistent high risk of recurrences dictates a search for the improvement of existing techniques and for the optimal combination of various tactics in treating lymphangiomas. In these group of patients, an important strategy is to have a personalized approach in each case. In our experience, a surgical intervention is the only technique for treating lymphangiomas of superficial location. This technique leads to simultaneous and radical removal of pathological formations within healthy tissues. Conclusions. Mostly important advantages of the discussed technique for treating lymphangiomas are: 1) A proper visualization of the formation and its complete removal what reduces the risk of relapses and lymphorrhea in the postoperative period. 2) Minimal tissue damage which leads to more rapid rehabilitation, less intensity of postoperative pain as well to less anesthesia support and less recovery period after surgery. 3) Better cosmetic effects.
SURGICAL CORRECTION OF TRUNK BALANCE IN SPINAL DEFORMITIES AND IN INSTABILITY OF HIP JOINTS
Authors: Chelpachenko O. B. , Zherdev K. V. , Fisenko A. P. , Butenko A. S. , Yatsyk S. P. , Dyakonova E. Yu. , Chelpachenko O. E.
Published: December 2020

Introduction. Restoration of trunk balance is the basic task in surgical correction of spinal deformities and in hip joint instability of various etiology. Purpose. To analyze and to define the relevance of roentgen-anatomical parameters of spine-pelvis relationships for surgical correction of deformities in the thoracolumbar spine and of hip joint instability of dysplastic and neurogenic etiology. Material and methods. An X-ray analysis of parameters of the frontal and sagittal spine-pelvis balance was performed in 220 patients with dysplastic and neurogenic deformities of the thoracic and lumbar spine (n = 98) and with instability of hip joints (n = 122) but who were able to walk. They were operated in the neuro-orthopedic department with orthopedics in National Medical Research Center for Children’s Health. The reference group included 60 relatively healthy children without any scoliotic deformities of the spine and with stable hip joints. Dynamics of changes in X-ray parameters was analyzed using findings of orthostatic spondylograms from the indicated groups of children. The obtained data were compared with reference values. Results. The trial performed has revealed typical changes in spine-pelvis relationship parameters in patients with hip joint instability and spine deformities and in the reference group . The researchers also found out relations between various parameters of the trunk balance before and after surgical correction. Conclusion. While planning a surgical correction of trunk balance in spinal deformities, one should take into account parameters of spine-pelvis relationships, such as PI, SS, PT, SVA deviation and the mid-sacral line; and in case of hip joint instability - local roentgen-angulometric parameters of the femoral and acetabular components of instability. This is due to the fact that the lower the level of reconstructive surgical manipulation is located, the greater effect it has at the frontal and sagittal balance of the trunk.
TREATMENT OF AN OPEN OMPHALOMESENTERIC DUCT IN NEWBORNS
Authors: Rekhviashvili M. G. , Yakovleva A. A. , Kruglyakov A. Yu. , Chusov K. P. , Kozlov M. Yu. , Syt'kov V. V.
Published: December 2020

This article describes two clinical cases of surgical treatment of children with an unobliterated bile duct. The first boy, aged 21 day, was admitted to the hospital with complaints of constant “wetness” in the umbilicus area and a lack of effect of conservative treatment. The fistulography showed communication with the iliac lumen what confirmed involution violation of the omphalomesenteric duct and the formation of complete umbilicus fistula. An unobliterated bile duct was incised and umbilical ring plasty with a surgical stapler was made under general anesthesia. The second child, aged 10 days, was transferred from a cardiosurgical hospital after the staged correction of a congenital heart defect. He had the intussusception of small intestine loops through the umbilical ring, with signs of ischemia. In anamnesis few days before, a yellow-green discharge from the umbilical wound was noted. The additional examination revealed that it was a complication of unobliterated complete omphalomesenteric fistula. Transumbilical incision and resection of intestinal necrotic area with further anastomosis were made; revision and sanitation of abdominal organs and layer-by-layer suturing of the wound were performed too. The postoperative course was uneventful. The described clinical cases demonstrate that primary care specialists (especially of non-surgical profile) have to be cautious about pathological processes in the umbilical region in newborns. If the conservative treatment is ineffective and in order to verify the diagnosis, consultation with a pediatric surgeon is recommended. If the X-ray contrast fistulography is indicated, it should be performed at a specialized hospital.
A MODIFIED ANTERIOR SAGITTAL APPROACH IN A H-TYPE RECTOVESTIBULAR FISTULA
Authors: Novozhilov V. A. , Stepanova N. M. , Petrov E. M.
Published: December 2020

A rectovestibular / rectovaginal fistula with a normally formed anus, so-called H-type (H-type fistula), is rather rare anorectal malformation which causes a serious problem for surgical correction of the defect. A surgical correction in infancy is associated with technical difficulties because of specific anatomical relationships and perineum topography in this age group. Thus, an improved surgical access which allows to get good anatomical and functional results and a worthy quality of life in such patients in future is a relevant issue. The authors describe a clinical case of successful treatment of H-type rectovestibular fistula with improved perineal access in a 1-year old child.
THE FIRST EXPERIENCE OF PNEUMOVESICOSCOPIC URETERAL REIMPLANTATION IN CHILDREN UNDER 2 YEARS OF AGE
Authors: Karpachev S. A. , Zorkin S. N. , Gurskaya A. S. , Tarzyan A. O. , Bayazitov R. R. , Zhamynchiev E. K. , Galuzinskaya A. T.
Published: December 2020

Actuality. To date, there are few publications focused on pneumovesicoscopic ureteral reimplantation in young children. The article is devoted to surgical interventions in this age group. Material and methods. Surgical interventions on small volume bladder have significant technical difficulties. The authors assessed potentials for performing pneumovesicoscopic ureteral reimplantation by the Cohen technique in 14 children under 2 with various obstructive uropathies. Results. In all children, surgical interventions were performed according to preoperative plans. There were no conversions to an open procedure. As it has been found out, patient’s age and bladder volume were not limiting factors for this type of intervention. Conclusion. The pneumovesicoscopic ureteral reimplantation in young children is a hi-tech procedure which requires a unique equipment and a highly qualified surgical team. To reduce the procedure duration, further experience and more information are needed.
MULTISPIRAL COMPUTED AND MAGNETIC RESONANCE IMAGING OF THORACOLUMBAR SPINE INJURY IN CHILDREN
Authors: Akhadov T. A. , Melnikov I. A. , Iskhakov O. S. , Bozhko O. V. , Kostikova T. D. , Manzhurtsev A. V. , Ublinsky M. V. , Meshcheryakov S. V. , Maksutov A. A.
Published: December 2020

Introduction. Spinal injury in pediatric practice is met relatively rare; spinal fractures in children do not exceed 5%, and the incidence rate does not exceed 5:100000. However, spinal injuries have a high rate of fetal outcomes (up to 5-10%), and have significant long-lasting negative effects. Therefore, to timely detect such injuries is extremely important for determining treatment tactics, preventing secondary damage to nerve structures and preventing the formation of spinal deformity. Purpose. To assess and compare CT and MRI potentials for developing a diagnostic algorithm in children with thoracolumbar spine injury. Material and methods. 4355 patients, aged 6 months - 17 years, with thoracolumbal spine injury were included into the study . All patients had radiography of the thoracic or lumbar spine and MRI of three spinal sections. Multispiral computed tomography ( MSCT) was performed with Brilliance 16 and 64 scanners. Information on the thoracolumbal spine picture obtained by scanning the chest and abdomen was assessed using findings of frontal and sagittal and 3D reformatted images. MRI was performed on Achieva 3 T scanner; multi-planar T1-, T2-weighted images of (WI) TSE and STIR images in axial, frontal and sagittal projections with a slice thickness of 2-4 mm were obtained. A special spinal 32 channel coil was used. Results. To compare the effectiveness of CT and MRI techniques in the diagnostics of thoracolumbar spinal injury, a sampling of 95 patients was selected. The number of injuries (total and their distribution by the type of injury) was defined using the sample findings. The total number of detected injuries was: only by MRI = 325; only by CT = 228; MRI + CT = 199. By the results of McNemar test, it has been found out that MRI detects statistically significantly better explosive fractures of the vertebrae, ruptures of the posterior longitudinal ligament (PLL) and yellow ligament (YL), ruptures of third column ligaments, herniated discs, epidural and sublingual hematomas, hematomyelia, complete and partial ruptures of the spinal cord and its edema; CT has superiority in detecting fractures of posterior vertebral elements. Conclusion. Currently, MSCT remains a key imaging technique in the diagnostics of acute spinal injuries in most cases in children and adults. Our findings confirm that MRI - in the absence of standard absolute contraindications - can serve as a worthy alternative for assessing damages of the vertebral bodies, ligaments, intervertebral discs, spinal cord and its roots in the acute stage of injury, yielding only in detecting injuries in vertebra posterior elements. The absence of ionizing radiation is also one of MSCT advantages which makes its use preferable for spinal injury diagnostics in children, both for primary and for control examinations.
ARTHROSCOPIC TREATMENT OF HEMATOGENOUS PATELLA OSTEOMYELITIS IN A 12-YEAR OLD CHILD
Authors: Mitish V. A. , Medinskiy P. V. , Basargin D. Yu. , Agayants A. O. , Dvornikova M. A. , Berezhnaia M. A. , Dmitrienko D. M.
Published: December 2020

Introduction. A rare disease in pediatric population - acute hematogenous osteomyelitis of the patella - is presented in the article by the authors. Diagnostic approaches and specificity in choosing a curative modality are described as well. A purulent focus in the patella was treated arthroscopically. Satisfactory outcomes in the shortest possible period were achieved due to the combined curative modality: antibiotic therapy, flow-lavage drainage of the joint and early rehabilitative measures. Purpose. To demonstrate potentials of modern diagnostic and endosurgical techniques for treating acute hematogenous osteomyelitis of the patella of rare location. Material and methods. In February 2017, a 12-year-old boy with acute hematogenous osteomyelitis of the right patella was examined and treated at the department of purulent surgery of the Research Institute of Emergency Pediatric Surgery and Trauma (CRIEPST). A complex of diagnostic techniques included laboratory (clinical analysis of blood and urine, biochemical blood test) and instrumental (ultrasound diagnostics of knee joints, computed tomography) examinations. Conservative treatment included antibacterial, anti-inflammatory and symptomatic therapy . Surgical debridement of the osteomyelitis focus in the knee joint was made arthroscopically. Results. Given the obtained data, the diagnosis of acute hematogenous osteomyelitis of the right patella was put. Location of the process, purulent effusion in the joint cavity and damaged articular surface of the patella urged surgeons to decide on the endosurgical treatment: arthroscopic cleansing of the purulent-necrotic focus of the patella and sanitation of the knee joint cavity. In the postoperative period, the child had medicamentous therapy, apparatus therapy, hyperbaric oxygenation therapy. The right lower limb was immobilized with a posterior plaster cast for 7 days. The joint was washed with physiological saline solution for 5 days, after which the drainage was left for passive aspiration for another two days. Standing-up position with crutches and emphasis on the low legs were achieved on the 7th postoperative day. On the 14th postoperative day, the child was discharged home in a satisfactory state. Catamnestic examination 4 months later revealed that the right knee joint was not externally changed, movements in the joint were in full range. Ultrasound examination did not reveal any pathology either. MRI examination revealed an area with reparative signs at the site of operated purulent focus which looked like a partial replacement of the bone defect. Conclusions. The arthroscopy is a minimally invasive and effective technique for surgical treatment of intra-articular purulent foci in acute hematogenous osteomyelitis of the patella.
Self-efficacy and identity statuses in students of Iran
Authors: Asayesh Mohammad Hassan , Vakili Mohsen
Published: December 2020

The purpose of the present study is to analyse the relationship between identity status and self-efficacy. The statistical population included all graduate students employed at the Training Centre of Ayatollah Khatami in the city of Yazd in 2009. The sample consisted of 122 students who were selected by convenience sampling. The chosen research method is descriptive correlational. Bennion and Adams’ Extended Objective Measure of Ego Identity Status and the Self-Efficacy Scale were used for measuring the identity statuses and self-efficacy. The results of this study show that there is a positive significant relationship between achieved identity status, self-efficacy (p < 0.01) and diffused identity; there is a negative significant relationship between diffused identity status and self-efficacy (p < 0.05); and there is a negative significant relationship between foreclosure identity status and self-efficacy (p < 0.01). According to this study, for providing qualified forces, the training centres can employ forces by detecting identity statuses and self-efficacy of volunteers.
 
Keywords: Identity, identity status, students, self-efficacy.
Relationship between personality factors and marital conflict resolution strategies among spouses in Abuja Municipal Area Council FCT Abuja
Authors: Ojeme Maria Chika
Published: December 2020

This study examined the relationship between personality factors and marital conflict resolution strategies among spouses in (AMAC) Federal Capital Territory Abuja. Two research questions and corresponding hypotheses were raised to guide this study. The personality factors such as educational qualification and length of marriage were the focus of this study. Samples of a hundred respondents consisting of 50 young and aged married couples, selected using the purposive sampling technique. The research questions were analysed using Pearson Product Moment correlation while the hypotheses were tested using the significance of Pearson (r) at 0.05 level of significance using t-test. The findings revealed that there is a significant relationship; between educational qualification and conflict resolution strategies of married people, also; between the length of marriage and conflict resolution strategies of married people. The study recommended that couples to be should get to understand each other in the area of likes and dislikes, ideologies and personality make-ups.
 
Keywords: Personality factors, marital conflict resolution strategies and spouses.
Transitional Justice: extension of the laws of reparation and the case of insilio in the Argentine Republic
Authors:   Universidad de Buenos Aires, Facultad de Derecho. Argentina, Cifre Puig Agustín Túpac ,   Universidad Nacional de Moreno. Argentina,   Universidad Nacional de Avellaneda. Argentina
Published: December 2020

This article presents a chronological timeline focused on the reparation policies carried out in Argentina since the end of the last military dictatorship in 1983 to the present. It illustrates their origin, starting with some few sectorized acknowledgments by public sector institutions until becoming a diverse regulation able to cover several cases. Such reparation policies have extended the compensation time frame, and by means of judicial interpretation, even the margins of the law. Finally, in the context of the expansion of reparation policies in Argentina, it is necessary to ask whether internal exile should be considered as a case that needs to be regulated, taking into account the loss of rights and the damage inflicted on those who suffered it. For this purpose, a series of interviews with different victims were conducted.
Configuration of the economic structure of La Pampa
Authors:   Universidad Nacional de La Pampa. Argentina, Ravier Adrián
Published: December 2020

The aim of this article is to define conceptually and quantitatively the economic structure of La Pampa. The scope of this research covers general characteristics of its territory, population and production, opening it in primary, secondary and tertiary production, and its consequent exports. Some social indicators, such as employment and income, or poverty and destitution are also analyzed.
7 Failure
Authors: Harding Rebecca , Gurowich Tim , Carter Kristen
Published: December 2020

Reflecting about 7.1. Failure (2017).
Can Manipulation of Soil Microbiota Enhance, Stabilize and Sustain Cannabinoid Production?
Authors: Ahmed Bulbul , Hijri Mohamed
Published: December 2020

Cannabis is one of the oldest cultivated crops in the history for food, fiber and drugs for thousands of years. Extension of cannabis genetic variation developed in a wide- ranging choice of varieties with various complementary phenotypes and secondary metabolites. Cannabis grow practices is very diverse, especially indoor cultivation factors, such as different lighting conditions, pot size, humidity, fertilizers. These growth factors influence a lot on the production of cannabinoids. For medical or pharmaceutical purposes, ratio of CBD or THC is very important. Plants traits and metabolic compounds are related to various conditions produced by microbes. Investigating this crosstalk between plants and microbes can play a vital role not only for stimulating the biosynthetic and signaling pathways of the host plants for the production of agronomically or pharmaceutically essential metabolic compounds but also against pathogens. This study emphasis on decoding the crosstalk between cannabis and associated microbes in the belowground environmental niches that would unravel the complexity of stabilizing cannabinoid production.
FYN, SARS-CoV-2, and IFITM3 in the Neurobiology of Alzheimer’s Disease: A Regulatory Feedback Loop Governing Tau and Aβ Pathology
Authors: Vavougios George , Breza Marianthi , Nikou Sofia , Krogfelt Karen
Published: December 2020

Introduction IFITM3, an innate immune protein linked to COVID-19 severity, has recently been identified as a novel γ-secretase modulator. Independent research has shown that IFITM3 may facilitate SARS-CoV-2 neurotropism in an ACE2-independent manner. In a previous study, we had detected perturbations in IFITM3 networks in both the CNS and peripheral immune cells donated by AD patients.The purpose of this study is to explore the transcriptomic evidence of the SARS-CoV-2 / IFITM3 / AD interplay, validating previous findings from our group. Methods Exploratory analyses involved meta-analysis of bulk and single cell RNA data for IFITM3 and FYN differential expression. For confirmatory analyses, we performed gene set enrichment analysis (GSEA) on an AD gene signature from AD Consensus transcriptomics; using the Enrichr platform, we scrutinized COVID-19 datasets for significant, overlapping enriched biological networks. Results Bulk RNA data analysis revealed that IFITM3 and FYN were differentially expressed in two CNS regions in AD: the temporal cortex (AD vs. Controls, adj.p-value=1.3e-6) and the parahippocampal cortex (AD vs. controls, adj.p-value=0.012). Correspondingly, single cell RNA analysis of IFITM3 and FYN revealed that it was differentially expressed in neuronal cells donated from AD patients (astrocytes, microglia and oligodendrocyte precursor cells), when compared to controls. Discussion IFITM3 and by extent FYN were found as interactors within biological networks overlapping between AD and SARS-CoV-2 infection. SARS-CoV-2 SARS-CoV-2-mediated IFITM3 induction would mechanistically result in increased Aβ production. FYN recruitment by viral processes results in abrogation of both fusion of IFITM3 vesicles with lysosomes; immunoevasion, by FYN-mediated impairment of autophagy would then serve to promote impaired detoxification from Aβ, while propagating Tau pathology in an IFITM3-independent manner.
The Oral Anticoagulants Administration in Elderly Patients with Geriatric Syndromes: What's New?
Authors: Vorobyeva N. M. , Tkacheva O. N.
Published: December 2020

The administration of oral anticoagulants in elderly patients with geriatric syndromes such as senile asthenia syndrome, falls and high risk of falls, dementia, polymorbidity, polypharmacy are discussed in the article. The evidence base for the anticoagulants taking in patients with atrial fibrillation aged ≥75, ≥80, ≥85 and ≥90 years, in patients with atrial fibrillation and various geriatric syndromes, as well as in elderly patients with venous thromboembolic complications and frailty syndrome is presented. Most studies indicate significant advantages of direct oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) over the vitamin K antagonist warfarin in elderly patients with geriatric syndromes. An updated version of the FORTA consensus document, which aims to optimize the prescription of medicines for the elderly, is also presented. Apixaban has a FORTA-A safety class and is the safest oral anticoagulant in elderly patients.
The Impact of the E-Learning Module on Remediation of Misconceptions in Modern Physics Courses
Authors: Halim A. , Soewarno Soewarno , Elmi Elmi , Zainuddin Zainuddin , Huda I. , Irwandi Irwandi
Published: December 2020

The misconception in mastering physics concepts occurs in basic physics and is also found in advanced physics, such as Modern Physics or Quantum Physics. Efforts to remediate misconceptions have been done manually or offline but are often constrained at too long an interval between identification activities and remediation actions. Through the advancement of online learning systems, E-learning media, these obstacles can easily be overcome. This article will discuss one way of remediation using Moodle-based E-Learning modules. A total of 2 classes (45 students) were randomly selected for the experimental group and two classes (64 students) for the control group. The experimental group used a representative module based on E-Learning as a remediation treatment, while the control group used a conventional module. The results of the validation of the material and the design of the E-Learning modules were obtained as very feasible to use. Data collection uses a two-tier Modern Physic Diagnostic Test or MPDT (Modern Physic Diagnostic Test) of 30 items combined with the CRI (Certainty of Response Index) index. It is carried out twice, namely before and after treatment. The N-Gain normality analysis results showed the percentage of misconception reduction was more significant in the experimental group than in the control group. Important note obtained by implementing E-Learning is more appropriate to be used simultaneously between conventional face-to-face and E-Learning.
A Meta-Analytic Reliability Generalization Study of the Oxford Happiness Scale in Turkish Sample
Authors: ÖZDEMİR Vildan , YILDIRIM Yıldız , TAN Şeref
Published: December 2020

The purpose of this study was to analyze the meta-analytical reliability generalization of short form and long form of the Oxford Happiness Scale (OHS) for Turkish sample. In addition, how different moderator variables affect reliability coefficients was examined. A number of criteria have been set to determine the studies to be included in meta-analysis. Of 95 Cronbach’s Alpha coefficients obtained from 92 studies that were selected according to criteria were included in the meta-analysis. In the data analysis, reliability generalization based on meta-analysis was used. The effect of moderator variables on variability in reliability estimations as effect size was examined by Analog ANOVA. As a result of the research, it was found that the mean alpha was .81 for overall studies; .76 for the short form and .87 for the long form of OHS. In addition, it was concluded that number of items had a statistically significant effect on the reliability estimation in terms of heterogeneity of true effect sizes, and sample type had a statistically significant effect on the reliability estimation for OHS (long-form). But sample type had no effect on the reliability estimation for OHS-S (short-form), and field of study had no effect for both short and long form reliability estimates.
LIVING HADIS PADA TRADISI TAWASUL DAN TABARUK DI MAKAM SUNAN BONANG LASEM REMBANG
Authors: Huda Nur
Published: December 2020

Tawasul dan Tabaruk merupakan tradisi yang sudah banyak dipraktekkan oleh masyarakat muslim pada saat berdoa di makam. Kedua tradisi ini juga sering disalahpahami sebagai praktek yang menjerumuskan kepada kemusyrikan. Penelitian ini bertujuan untuk mengungkap aspek living hadis pada tradisi tawasul dan tabaruk warga Desa Bonang di makam Sunan Bonang dengan menggunakan metode deskriptif induktif, dan menganalisisnya dengan teori tindakan sosial Max Weber. Penelitian ini menghasilkan beberapa temuan. Pertama, tradisi ini merupakan suatu living hadis. Kedua, berdasarkan tipe tindakan tradisional, para pelaku tradisi ingin terus menerus menghormati Sunan Bonang dengan cara melestarikan tradisi yang sudah dilakukan secara turun temurun. Ketiga, tindakan afektif, memperlihatkan bahwa para pelaku memiliki ikatan emosional dengan para tokoh agama dan waktu pelaksanaan (malam Jumat). Keempat, tindakan instrumental rasional, para pelaku secara sadar mampu melaksanakan tradisi tersebut, baik dari aspek sumber daya manusia maupun aspek finansial. Kelima, rasionalitas nilai, pelaku ingin meniru perilaku tokoh-tokoh agama dan membiasakan diri bersedekah sekaligus ingin menanamkan nilai solidaritas jamaah.

 

[Tawasul and Tabaruk Traditions in Sunan Bonang’s Tomb Lasem Rembang: A Study of Living Hadith. Tawasul and tabaruk are traditions that have been widely practiced by Muslim communities when praying at the grave. These two traditions are also often misunderstood as practices that lead to idolatry. This study aims to reveal aspects of the living hadith in the tradition of tawasul and tabaruk of the people of Bonang Village in the Sunan Bonang tomb by using the inductive descriptive method, and by analyzing it through Max Weber's theory of social action. This study yielded several findings. First, this tradition is a living hadith. Second, based on the type of traditional action, traditional actors want to continue to respect Sunan Bonang by preserving traditions that have been carried out from generation to generation. Third, affective action shows that peoples have an emotional bond with religious leaders (ulama) and the time of implementation (Thursday night). Fourth, rational instrumental action, where the actors are consciously able to carry out the tradition, both from the human resource and financial aspects. Fifth, value rationality, the people want to imitate the behavior of religious figures and get used to giving alms at the same time wants to instill the value of solidarity among the jama'a.]
Implementation of Self-Assessment on The Formative Test in Chemistry Using Feedback Clue
Authors: Siswaningsih Wiwi , Susetyo Budi , Pujiastuti Zakiyah
Published: December 2020

This study aims to describe the compliance every stage of self-assessment implementation of upper secondary school students on the topic of salt hydrolysis formative test by using feedback instructions (clue), the ability of students to conduct self-assessment on the salt hydrolysis formative test by using feedback instructions, as well as the ability of self-assessment on the formative salt hydrolysis test to be used as feedback of upper secondary school students. This research was conducted by using a descriptive method that involved 27 eleventh graders who took the Science program. The research was conducted in six stages with different compliance in every stage. The compliance category of the students’ motivation and self-assessment training stage was good, the implementation stage of a formative test using feedback instructions (clue) was good, the implementation stage of self-assessment was very good, the stage of communicating the results for feedback (ideal criteria implemented) was very good, and the stage of utilizing the results was very good. In the implementation of self-assessment, most students could carry out self-assessment well. Besides, it has also known that students were satisfied with the feedback given by using the self-assessment rubric and they got benefits in the form of feedback clue from the self-assessment rubric. This result showed that self-assessment helped educators in providing feedback to the student.
Failure Rates of Autograft and Allograft ACL Reconstruction in Patients 19 Years of Age and Younger
Authors: Cruz Aristides I. , Beck Jennifer J. , Ellington Matthew D. , Mayer Stephanie W. , Pennock Andrew T. , Stinson Zachary S. , VandenBerg Curtis D. , Barrow Brooke , Gao Burke , Ellis Henry B.
Published: December 2020

Background:

Graft choice for pediatric anterior cruciate ligament reconstruction (ACLR) is determined by several factors. There is limited information on the use and outcomes of allograft ACLR in pediatric patients. The purpose of this systematic review and meta-analysis was to quantify reported failure rates of allograft versus autograft ACLR in patients ≤19 years of age with ≥2 years of follow-up. We hypothesized that there would be higher rates of failure for allograft compared with autograft ACLR in this population.

Methods:

PubMed/MEDLINE and Embase databases were systematically searched for literature regarding allograft and autograft ACLR in pediatric/adolescent patients. Articles were included if they described a cohort of patients with average age of ≤19 years, had a minimum of 2 years of follow-up, described graft failure as an outcome, and had a Level of Evidence grade of I to III. Qualitative review and quantitative meta-analysis were performed to compare graft failure rates. A random-effects model was created to compare failure events in patients receiving allograft versus autograft in a pairwise fashion. Data analysis was completed using RevMan 5.3 software (The Cochrane Collaboration).

Results:

The database search identified 1,604 studies; 203 full-text articles were assessed for eligibility. Fourteen studies met the inclusion criteria for qualitative review; 5 studies were included for quantitative meta-analysis. Bone-patellar tendon-bone (BTB) represented 58.2% (n = 1,012) of the autografts, and hamstring grafts represented 41.8% (n = 727). Hybrid allografts (autograft + supplemental allograft) represented 12.8% (n = 18) of all allograft ACLRs (n = 141). The unweighted, pooled failure rate for each graft type was 8.5% for BTB, 16.6% for hamstring, and 25.5% for allograft. Allografts were significantly more likely than autografts to result in graft failure (odds ratio, 3.87; 95% confidence interval, 2.24 to 6.69).

Conclusions:

Allograft ACLR in pediatric and adolescent patients should be used judiciously, as existing studies revealed a significantly higher failure rate for allograft compared with autograft ACLR in this patient population. Additional studies are needed to improve the understanding of variables associated with the high ACLR failure rate among pediatric and adolescent patients.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Disiplin kerja dalam meningkatkan kinerja perawat melalui motivasi sebagai variabel intervening
Authors: Arifah Marro , Safrizal Helmi Buyung Aulia , Fathor A.S
Published: December 2020

This study aims to examine the effect of work discipline in improving nurse performance and to examine the mediating role of motivation. The study used a quantitative approach at the Syarifah Ambami Rato Ebu Bangkalan Regional Hospital. Data collection using a questionnaire to 72 nurses as respondents. The research variables consisted of work discipline, nurse performance and motivation as mediating variables. Data analysis using Path Analysis. The results showed that work discipline has a positive and significant effect on nurses' performance; Work discipline has a positive and significant effect on nurses' motivation, then nurses' motivation has a positive and significant effect on nurses' performance. So motivation plays a role in mediating the effect of work discipline on nurse performance.
An Interim Report on Predicting Pressure Rise due to the Thermal Expansion of Trapped Liquids in Subsea Oil and Gas Equipment
Authors: Somassoundirame Ramechecandane , Nithiyananthan Eswari
Published: December 2020

The objective of the present work is to propose a methodology to predict pressure rise due to the thermal expansion of trapped liquids using computational fluid dynamics (CFD). The present study also provides a comparison between the various methods used for pressure buildup calculations that are widely used in oil and gas industries. A comparison of standard thermodynamic calculations with transient 3D CFD analysis reveals that transient CFD analyses can provide deeper insights on the temperature and velocity fields in trapped volumes. The application of the proposed method is not just restricted to a single component/equipment in the subsea field but can be applied to any trapped volume in subsea equipment. In the present study, the pressure buildup in a downhole (DH) port of a subsea Christmas tree (XT) is presented for demonstration purposes; the same methodology can be extended to other equipment or regions of interest. Because of a lack of literature on the topic of pressure rise due to thermal expansion of trapped fluids, engineers are forced to make several assumptions without knowing the effect of each term or parameter on the final pressure calculated. In this study, the percentage change/variation of the final pressure using the various forms of a standard analytical pressure rise equation is also discussed in detail.
The role of social network support on treatment outcomes for medication for opioid use disorder: a systematic review protocol
Authors: Kumar Navin , Howell Benjamin A. , Alexander Marcus , O'Connor Patrick G.
Published: December 2020

Background Although medications for opioid use disorder (MOUD) models are the most efficacious evidence-based treatment for opioid use disorder, there remains a high percentage of patients experiencing unfavorable treatment outcomes. Greater understanding of how social network support functions with respect to MOUD treatment outcomes may possibly improve treatment outcomes. Social network support are the kinds of support, such as assistance or help, that people receive from friends, family, peers and neighbors, paid or unpaid, in their social network. We aim to provide quality evidence to understand the role of social network support on MOUD treatment outcomes. Methods A systematic review of experimental and observational studies will be conducted. PubMed, MEDLINE, Embase, PsycINFO and Sociological Abstracts will be searched. Primary outcomes will include adherence to MOUD, defined as continuation in or completion of an MOUD program; and opioid use, defined as the percentage of urine samples negative for opioids and/or self-reported drug use. The systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Quality assessments will be conducted using criteria from the Cochrane Handbook. A narrative synthesis will be conducted for all included studies. Discussion This systematic review seeks to provide policymakers, administrators, practitioners and researchers with a systematic and reproducible strategy to query the literature around the role of social network support on MOUD treatment outcomes. Systematic review registration International Prospective Register for Systematic Reviews (PROSPERO), CRD42018095645.