bluuebunny/crossref_metadata_2025 huggingface dataset:
Mediating Effect and Suppressing Effect: Intermediate Mechanism of Urban Land Use Efficiency and Economic Development
Authors: Zhong Xueli , Li Yongfeng
Published: May 2023

The limited nature of land supply determines that improving land use efficiency is an inherent requirement for economic development. The aim of this study was to quantitatively examine its impact. Most current studies have explored the quantitative relationship between urban land use efficiency (ULUE) and economic development, but less attention has been given to the mechanism of action of both. In this study, we construct an analysis framework for the mechanism of ULUE in promoting economic development from three aspects: economic scale, economic structure, and economic quality, and we quantitatively investigate its impact on economic development and intermediate action mechanism through a mediating effect model on the basis of measuring ULUE by using a super-efficiency SBM-undesirable model. Based on the analysis of the panel data of 56 cities in the Yellow River Basin (YRB), the results show that, first, ULUE has formed an ideal positive driving effect on economic development, and its influence mechanism has obvious heterogeneity in cities with different geographical locations and resource endowments. Second, ULUE affects economic development through three channels: economic scale-up effect, economic structure optimization effect, and economic quality enhancement effect, and there are two different mechanisms of mediating effect and suppressing effect. Finally, variables such as investment intensity of urban construction land and social benefit act as suppressing effects, while variables such as economic output density of urban land, industrial structure, employment structure, economic benefit, and environmental benefit play partial mediating effects. These evidence-based findings can provide practical guidance for solving the dilemma of a lack of economic development momentum and inefficient land use in a country or region.
The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Authors: Rahnea-Nita Roxana-Andreea , Stoian Alexandru-Rares , Anghel Rodica-Maricela , Rebegea Laura-Florentina , Ciuhu Anda-Natalia , Bacinschi Xenia-Elena , Zgura Anca-Florina , Trifanescu Oana-Gabriela , Toma Radu-Valeriu , Constantin Georgiana Bianca , Rahnea-Nita Gabriela
Published: May 2023

Introduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of hyponatremia in cancer patients, occurring most frequently in patients with small cell lung cancer. However, this syndrome occurs extremely rarely in patients with non-small cell lung cancer. The results of the clinical trials have revealed that immuno-oncological therapies are effective for long periods of time, providing hope for long survival and with a good quality of life. Case Presentation: We present the case of a female patient who was 62 years old at the time of diagnosis in 2016 who underwent surgery for a right pulmonary tumor (pulmonary adenocarcinoma) and subsequently underwent adjuvant chemotherapy. The patient had a left inoperable mediastinohilar relapse in 2018, which was treated using polychemotherapy The patient also had an occurrence of progressive metastasis and a syndrome of inappropriate antidiuretic hormone secretion (SIADH) in 2019 for which immunotherapy was initiated. The patient has continued with immunotherapy until the time this study began to be written (April 2023), the results being the remission of hyponatremia, the clinical benefits and long-term survival. Discussion: The main therapeutic option for SIADH in cancer patients is the treatment of the underlying disease, and its correction depends almost exclusively on a good response to oncological therapy. The initiation of immunotherapy at the time of severe hyponatremia occurrence led to its remission as well as the remission of the other two episodes of hyponatremia, which the patient presented throughout the evolution of the disease, demonstrating an obvious causal relationship between SIADH and the favorable response to immunotherapy. Conclusions: Each patient must be approached individually, taking into account the various particular aspects. Immunotherapy proves to be the innovative treatment that contributes to increasing the survival of patients with metastatic non-small cell lung cancer and to increasing their quality of life.
Microstructure and Mechanical Properties of Weaving Wire and Arc Additive Manufactured AZ91 Magnesium Alloy Based on Cold Metal Transfer Technique
Authors: Zhang Zhongrui , Shen Junqi , Bi Ji , Hu Shengsun , Zhen Yahui , Bu Xianzheng
Published: May 2023

Based on the cold metal transfer (CMT) technique, a deposited wall of AZ91 magnesium alloy was fabricated by weaving wire and arc additive manufacturing (WAAM), the shaping, microstructure, and mechanical properties of the sample with the weaving arc were characterized and discussed by compared with the sample without the weaving arc, and the effects of the weaving arc on grain refinement and property enhancement of the AZ91 component by CMT-WAAM process were investigated. After introducing the weaving arc, the effective rate of the deposited wall could be increased from 84.2% to 91.0%, and the temperature gradient of the molten pool could be reduced with an increase in constitutional undercooling. The equiaxed α-Mg grains became more equiaxial due to the dendrite remelting, and the β-Mg17Al12 phases distributed uniformly induced by the forced convection after introducing the weaving arc. Compared to the deposited component fabricated by the CMT-WAAM process without the weaving arc, the average ultimate tensile strength and elongation of the component by weaving the CMT-WAAM process both increased. The weaving CMT-WAAM component showed isotropy and has better performance than the traditional cast AZ91 alloy.
Highly Efficient ITO-Free Quantum-Dot Light Emitting Diodes via Solution-Processed PEDOT:PSS Semitransparent Electrode
Authors: Ma Jin Hyun , Kim Min Gye , Jeong Jun Hyung , Park Min Ho , Ha Hyoun Ji , Kang Seong Jae , Kang Seong Jun
Published: May 2023

We present a study on the potential use of sulfuric acid-treated poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) as a viable alternative to indium tin oxide (ITO) electrodes in quantum dot light-emitting diodes (QLEDs). ITO, despite its high conductivity and transparency, is known for its disadvantages of being brittle, fragile, and expensive. Furthermore, due to the high hole injection barrier of quantum dots, the need for electrodes with a higher work function is becoming more significant. In this report, we present solution-processed, sulfuric acid-treated PEDOT:PSS electrodes for highly efficient QLEDs. The high work function of the PEDOT:PSS electrodes improved the performance of the QLEDs by facilitating hole injection. We demonstrated the recrystallization and conductivity enhancement of PEDOT:PSS upon sulfuric acid treatment using X-ray photoelectron spectroscopy and Hall measurement. Ultraviolet photoelectron spectroscopy (UPS) analysis of QLEDs showed that sulfuric acid-treated PEDOT:PSS exhibited a higher work function than ITO. The maximum current efficiency and external quantum efficiency based on the PEDOT:PSS electrode QLEDs were measured as 46.53 cd/A and 11.01%, which were three times greater than ITO electrode QLEDs. These findings suggest that PEDOT:PSS can serve as a promising replacement for ITO electrodes in the development of ITO-free QLED devices.
Heat Treatment Optimization for a High Strength Al–Mn–Sc Alloy Fabricated by Selective Laser Melting
Authors: Liu Hongyu , Zhang Hao , Meng Liju , Li Yulong , Cao Sheng
Published: May 2023

A selective laser-melted Al–Mn–Sc alloy with 99.9% relative density has been obtained in this work through systematic process optimization. The as-fabricated specimen had the lowest hardness and strength, but the highest ductility. The aging response has shown that 300 °C/5 h is the peak aged condition, and it had the highest hardness, yield strength, ultimate tensile strength, and elongation at fracture. Such a high strength was attributed to the uniformly distributed nano-sized secondary Al3Sc precipitates. A further increase in aging temperature to 400 °C resulted in an over-aged condition, which contained a reduced volume fraction of secondary Al3Sc precipitates and resulted in a reduced strength.
Preparation, Characterization, and Chemically Modified Date Palm Fiber Waste Biomass for Enhanced Phenol Removal from an Aqueous Environment
Authors: Siva Kumar Nadavala , Asif Mohammad , Poulose Anesh Manjaly , Al-Ghurabi Ebrahim H. , Alhamedi Shaddad S. , Koduru Janardhan Reddy
Published: May 2023

The date palm tree is extensively cultivated in Middle Eastern countries such as Saudi Arabia, generating a large amount of waste in the form of leaves, seeds, and fibrous materials. This study examined the feasibility of using raw date palm fiber (RDPF) and NaOH chemically modified date palm fiber (NaOH–CMDPF) obtained from discarded agricultural waste for the removal of phenol in an aqueous environment. The adsorbent characterization was performed by using different techniques, i.e., particle size analysis; elemental analyzer (CHN); and BET, FTIR, and FESEM-EDX analysis. The FTIR analysis revealed the presence of various functional groups on the surface of the RDPF and NaOH–CMDPF. The results showed that chemical modification by NaOH increased the phenol adsorption capacity that was well-fitted by the Langmuir isotherm. Higher removal was obtained with NaOH–CMDPF (86%) than with the RDPF (81%). The RDPF and NaOH–CMDPF sorbents’ maximum (Qm) adsorption capacities were more than 45.62 mg/g and 89.67 mg/g and were comparable to the sorption capacities of various other types of agricultural waste biomass reported in the literature. The kinetic studies confirmed that the adsorption of phenol followed the pseudo-second-order kinetic process. The present study concluded that the RDPF and NaOH–CMDPF were eco-friendly and cost-effective in promoting sustainable management and the reuse of the Kingdom’s lignocellulosic fiber waste material.
Investigation of Microstructure and Mechanical Properties of SAC105 Solders with Sb, In, Ni, and Bi Additions
Authors: Gao Yaxin , Bian Xilei , Qiu Xingbao , Jia Yandong , Yi Jun , Wang Gang
Published: May 2023

Low Ag lead-free Sn-Ag-Cu (SAC) solders have attracted great interest due to their good drop resistance, high welding reliability, and low melting point. However, low Ag may lead to the degradation of the mechanical properties. Micro-alloying is an effective approach to improving the properties of SAC alloys. In this paper, the effects of minor additions of Sb, In, Ni, and Bi on microstructure, thermal and mechanical properties of Sn-1 wt.%Ag-0.5 wt.%Cu (SAC105) were systematically investigated. It is found that the microstructure can be refined with intermetallic compounds (IMCs) distributed more evenly in the Sn matrix with additions of Sb, In, and Ni, which brings a combined strengthening mechanism, i.e., solid solution strengthening and precipitation strengthening, leading to the tensile strength improved of SAC105. When Ni is substituted by Bi, the tensile strength is further enhanced with a considerable tensile ductility higher than 25%, which still meets the practical demands. At the same time, the melting point is reduced, the wettability is improved, and the creep resistance is enhanced. Among all the investigated solders, SAC105-2Sb-4.4In-0.3Bi alloy possesses the optimized properties, i.e., the lowest melting point, the best wettability, and the highest creep resistance at room temperature, implying that element alloying plays a vital role in improving the performance of SAC105 solders.
Numerical Investigation of the Fractional Oscillation Equations under the Context of Variable Order Caputo Fractional Derivative via Fractional Order Bernstein Wavelets
Authors: Rayal Ashish , Joshi Bhagawati Prasad , Pandey Mukesh , Torres Delfim F. M.
Published: May 2023

This article describes an approximation technique based on fractional order Bernstein wavelets for the numerical simulations of fractional oscillation equations under variable order, and the fractional order Bernstein wavelets are derived by means of fractional Bernstein polynomials. The oscillation equation describes electrical circuits and exhibits a wide range of nonlinear dynamical behaviors. The proposed variable order model is of current interest in a lot of application areas in engineering and applied sciences. The purpose of this study is to analyze the behavior of the fractional force-free and forced oscillation equations under the variable-order fractional operator. The basic idea behind using the approximation technique is that it converts the proposed model into non-linear algebraic equations with the help of collocation nodes for easy computation. Different cases of the proposed model are examined under the selected variable order parameters for the first time in order to show the precision and performance of the mentioned scheme. The dynamic behavior and results are presented via tables and graphs to ensure the validity of the mentioned scheme. Further, the behavior of the obtained solutions for the variable order is also depicted. From the calculated results, it is observed that the mentioned scheme is extremely simple and efficient for examining the behavior of nonlinear random (constant or variable) order fractional models occurring in engineering and science.
On Study of the Occurrence of Earth-Size Planets in Kepler Mission Using Spatial Poisson Model
Authors: Yang Hong-Ding , Lee Yun-Huan , Lin Che-Yang
Published: May 2023

The problem of determining the occurrence rate for Earth-size planets orbiting Sun-like stars is emerging in the universe. We propose a methodology based on a spatial Poisson regression model with model parameters being inferred by the Bayesian framework to investigate this occurrence rate. We analyzed an exoplanet sample and its corresponding survey completeness data. Our results suggest that 46% of Sun-like stars have an Earth-size (i.e., 1–2 times Earth radii) planet with an orbital period of 5–100 days. Furthermore, we are also interested in the occurrence rate of Earth analogs hosted by GK dwarf stars (i.e., orbital period of 200–400 days and size 1–2 times Earth radii). After completeness correction, we obtained an occurrence rate of 0.18% based on the proposed methodology.
A Review of System-in-Package Technologies: Application and Reliability of Advanced Packaging
Authors: Wang Haoyu , Ma Jianshe , Yang Yide , Gong Mali , Wang Qinheng
Published: May 2023

The system-in-package (SiP) has gained much interest in the current rapid development of integrated circuits (ICs) due to its advantages of integration, shrinking, and high density. This review examined the SiP as its focus, provides a list of the most-recent SiP innovations based on market needs, and discusses how the SiP is used in various fields. Reliability issues must be resolved if the SiP is to operate normally. Three factors—thermal management, mechanical stress and electrical properties—can be paired with specific examples in order to detect and improve package reliability. This review provides a thorough overview of SiP technology, serves as a guide and foundation for the SiP in package reliability design, and addresses the challenges and potential for further development of this kind of package.
Mandatory Notification of Panton–Valentine Leukocidin-Positive Methicillin-Resistant Staphylococcus aureus in Saxony, Germany: Analysis of Cases from the City of Leipzig in 2019
Authors: Helbig Utta , Riemschneider Constance , Werner Guido , Kriebel Nancy , Layer-Nicolaou Franziska
Published: May 2023

In Germany, Saxony is the only federal state where the detection of a Panton–Valentine Leukocidin (PVL)-positive Methicillin-resistant Staphylococcus aureus (MRSA) has to be notified to the local health authority (LHA). The LHA reports the case to the state health authority and introduces concrete infection control measures. We analyzed isolates from the respective cases in 2019, which were collected in local microbiological laboratories and sent to the National Reference Centre (NRC) for Staphylococci and Enterococci for strain characterization and typing. Antibiotic resistance testing was done by broth microdilution. Molecular characterization was performed using spa and SCCmec typing, MLST, and the PCR detection of marker genes associated with distinct MRSA lineages. Demographic and clinical data of the individual cases were assessed and the LHA performed epidemiological investigations. Thirty-nine (index) persons, diagnosed with a PVL-positive MRSA, were initially reported to the LHA. Most patients suffered from skin and soft-tissue infections (SSTI). For 21 of the index cases, household contacts were screened for MRSA. Seventeen out of 62 contacts were also colonized with a PVL-positive MRSA. The median age of altogether 58 individuals was 23.5 years. In over half of the cases, the home country was not Germany and/or a history of travel or migration was reported. Molecular characterization revealed the presence of various epidemic community-associated MRSA lineages, with “USA300”, including the North American Epidemic (ST8-MRSA-IVa) and the South American Epidemic Clone (ST8-MRSA-IVc), the “Sri Lankan Clone” (ST5-MRSA-IVc), and the “Bengal Bay Clone” (ST772-MRSA-V) being more prevalent. In eight out of nine households, the contact persons were colonized with the same clone as the respective index case, suggesting a close epidemic and microbiological link. The obligation to report PVL-positive MRSA enables us to detect the occurrence of PVL-producing MRSA and its spread in the population as early as possible. Timely detection allows the targeted deployment of reliable anti-infective measures.
Analysis of Etiology of Community-Acquired and Nosocomial Urinary Tract Infections and Antibiotic Resistance of Isolated Strains: Results of a 3-Year Surveillance (2020–2022) at the Pediatric Teaching Hospital in Warsaw
Authors: Wanke-Rytt Monika , Sobierajski Tomasz , Lachowicz Dominika , Seliga-Gąsior Dominika , Podsiadły Edyta
Published: May 2023

Urinary tract infections (UTIs) remain the most common infections diagnosed in outpatients and hospitalized patients. This study was designed to determine the patterns of antibiotic resistance and the prevalence of uropathogens causing UTIs in pediatric patients hospitalized between 1 January 2020 and 31 December 2022 at Teaching Hospital in Warsaw. The most frequent species isolated from urine samples were E. coli (64.5%), Klebsiella spp. (11.6%), and Enterococcus spp. (6.1%). UTIs caused by Enterobacter spp., Enterococcus spp., and Klebsiella spp. were significantly more common in children younger than three months of age than in children older than three months (p < 0.001). Trimethoprim and trimethoprim–sulfamethoxazole were the least active compounds against Enterobacterales with the resistance of E. coli, Klebsiella spp., P. mirabilis, and Enterobacter spp. in the range of 26.7/25.2%, 48.4/40.4%, 51.1/40.4%, and 15.8/13.2% respectively. Ampicillin was also found to have resistance rates for E. coli of 54.9% and P. mirabilis of 44.7%. Cefalexin and cefuroxime were highly active towards Enterobacterales except for Klebsiella spp., in which the resistance level reached 40%. Regarding third- and fourth- generation cephalosporins, resistance in E. coli and P. mirabilis was observed in approximately 2–10% of the isolates, but in Klebsiella spp. and Enterobacter spp. ranged over 30%. The resistance of Enterobacterales to carbapenems, nitrofurantoin, and fosfomycin was below 1%. The quinolones resistance was very high for Klebsiella spp. (31.1%) and P. mirabilis (29.8%) and three times lower for E. coli (11.9%), P. aeruginosa (9.3%), Enterobacter spp. (2.6%), and E. faecalis (4.6%). Resistance to multiple antibiotic classes was identified in 396 Enterobacterales strains, 394 of which were multi-drug resistant (MDR) and 2 were extensive drug-resistant (XDR). In the case of E. coli, 30% of isolates were MDR, with the proportion of strains having this exact resistance pattern similar in all of the analyzed years; no E. coli XDR strains were isolated. The number of Klebsiella spp. MDR strains was much higher in 2022 (60%) than in 2021 (47.5%). In the analyzed time, only one strain of K. pneumonia XDR, producing New Delhi metallo-β-lactamase, was isolated. Monitoring infection trends is essential to improve control and limit the rise of bacterial resistance.
Flowable Mixtures of Treated Soils for Repairing Damage Caused by Burrowing Animals
Authors: Nocilla Alessandra , Bassi Agnese , Rosso Alessandro , Turla Giada , Zimbardo Margherita
Published: May 2023

The adoption of flowable mixtures of treated soils is suggested as a sustainable solution for repairing the damage caused by burrowing animals in the Po River embankments. Soil from damaged sites is proposed to be mixed with lime or cement, other additives, and water in order to obtain mixtures with an adequate compromise between viscosity—which is crucial for flowing the mixture into the hole with site machines—and shrinkage that might occur over time according to the hole boundary conditions. Injections of soil-treated mixtures must guarantee hydraulic and mechanical continuity with the existing embankment and reduce shrinkage phenomena that frequently occur with cement–bentonite grout, which is commonly used for this purpose. This study presents an interdisciplinary experimental programme in the search for the best formulation among several recipes of mixtures of soils, collected from four embankments of Po River or its tributaries and treated with lime or cement, different percentages of water, and other additives. The mixtures, after soil classification and viscosity determinations, were then used to create samples for which shrinkage and erosion susceptibility were estimated, respectively, through a non-standard volume measurement procedure and crumb tests. An abacus will be then proposed in order to give, as a first estimation, applicative indications on the best recipe among the investigated mixtures.
Determination of Glycerol, Propylene Glycol, and Nicotine as the Main Components in Refill Liquids for Electronic Cigarettes
Authors: Kubica Paweł
Published: May 2023

Refill liquids for electronic cigarettes are an important area of research due to the health safety and quality control of such products. A method was developed for the determination of glycerol, propylene glycol, and nicotine in refill liquids using liquid chromatography, coupled with tandem mass spectrometry (LC-MS/MS) in multiple reaction monitoring (MRM) mode with electrospray ionisation (ESI). Sample preparation was based on a simple dilute-and-shoot approach, with recoveries ranging from 96 to 112% with coefficients of variation < 6.4%. Linearity, limits of detection and quantification (LOD, LOQ), repeatability, and accuracy were determined for the proposed method. The proposed sample preparation and the developed chromatographic method using hydrophilic interaction liquid chromatography (HILIC) were successfully applied for the determination of glycerol, propylene glycol, and nicotine in refill liquid samples. For the first time, the developed method using HILIC-MS/MS has been applied for the determination of the main components of refill liquids in a single analysis. The proposed procedure is rapid and straightforward and is suitable for quick determination of glycerol, propylene glycol, and nicotine. The nicotine concentrations corresponded to the labelling of samples (it varied from <LOD—11.24 mg/mL), and the ratios of propylene glycol to glycerol were also determined.
Revealing the Combined Effect of Active Sites and Intra-Particle Diffusion on Adsorption Mechanism of Methylene Blue on Activated Red-Pulp Pomelo Peel Biochar
Authors: Wei Fang , Jin Shenglong , Yao Chunyi , Wang Tianhao , Zhu Shengpu , Ma Yabiao , Qiao Heng , Shan Linxi , Wang Rencong , Lian Xiaoxue , Tong Xiaoqiang , Li Yan , Zhao Qiang , Song Weiguo
Published: May 2023

Phosphoric acid-activated biochar has been proven to be a promising adsorbent for pollutant removal in an aqueous solution. It is urgent to understand how surface adsorption and intra-particle diffusion synergistically contribute to the adsorption kinetic process of dyes. In this work, we prepared a series of PPC adsorbents (PPCs) from red-pulp pomelo peel under different pyrolysis temperatures (150–350 °C), which have a broad specific surface area range from 3.065 m2/g to 1274.577 m2/g. The active sites on the surface of PPCs have shown specific change laws of decreasing hydroxyl groups and increasing phosphate ester groups occurring as the pyrolysis temperature rises. Both reaction models (PFO and PSO models) and diffusion models (intra-particle diffusion models) have been applied to simulate the adsorption experimental data to verify the hypothesis deduced from the Elovich model. PPC-300 exhibits the highest adsorption capacity of MB (423 mg/g) under given conditions. Due to its large quantities of active sites on the external and internal surfaces (1274.577 m2/g), a fast adsorption equilibrium can be achieved within 60 min (with an initial MB concentration of 100 ppm). PPC-300 and PPC-350 also exhibit an intra-particle-diffusion-controlled adsorption kinetic process with a low initial MB concentration (100 ppm) or at the very beginning and final stage of adsorption with a high initial MB concentration (300 ppm) at 40 °C, considering that the diffusion is likely hindered by adsorbate molecules through internal pore channels at the middle stage of adsorption in these cases.
Cattail-Grass-Derived Porous Carbon as High-Capacity Anode Material for Li-Ion Batteries
Authors: Li Hui , Song Lingyue , Huo Dongxing , Yang Yu , Zhang Ning , Liang Jinglong
Published: May 2023

Cattail-grass-derived porous carbon as high-capacity anode materials were prepared via high-temperature carbonization and activation with KOH. The samples exhibited different structures and morphologies with increasing treatment time. It was found that the cattail grass with activation treatment—1 (CGA-1) sample obtained at 800 °C for 1 h presented excellent electrochemical performance. As an anode material for lithium-ion batteries, CGA-1 showed a high charge–discharge capacity of 814.7 mAh g−1 at the current density of 0.1 A g−1 after 400 cycles, which suggests that it has a great potential for energy storage.
Synthesis and Application of Porous Carbon Nanomaterials from Pomelo Peels: A Review
Authors: Liu Zixuan , Yang Qizheng , Cao Lei , Li Shuo , Zeng Xiangchen , Zhou Wenbo , Zhang Cheng
Published: May 2023

Advanced carbon nanomaterials have been widely applied in various fields such as microelectronics, energy storage, catalysis, adsorption, biomedical engineering, and material strengthening. With the increasing demand for porous carbon nanomaterials, many studies have explored obtaining porous carbon nanomaterials from biomass, which is highly abundant. Pomelo peel, a type of biomass rich in cellulose and lignin, has been widely upgraded into porous carbon nanomaterials with large yield and significant applications. Here, we systematically review the recent progress in pyrolysis, activation, and applications of synthesizing porous carbon nanomaterials from waste pomelo peels. Moreover, we provide a perspective on the remaining challenges and potential future research directions.
On the Gas-Phase Interactions of Alkyl and Phenyl Formates with Water: Ion–Molecule Reactions with Proton-Bound Water Clusters
Authors: Diedhiou Malick , Mayer Paul M.
Published: May 2023

Ion–molecule reactions between the neutral ethyl- (EF), isopropyl- (IF), t-butyl- (TF) and phenyl formate (PF) and proton-bound water clusters W2H+ and W3H+ (W = H2O) showed that the major reaction product is water loss from the initial encounter complex, followed ultimately by the formation of the protonated formate. Collision-induced dissociation breakdown curves of the formate–water complexes were obtained as a function of collision energy and modeled to extract relative activation energies for the observed channels. Density functional theory calculations (B3LYP/6-311+G(d,p)) of the water loss reactions were consistent with reactions having no reverse energy barrier in each case. Overall, the results indicate that the interaction of formates with atmospheric water can form stable encounter complexes that will dissociate by sequential water loss to form protonated formates.
Connection between Celiac Disease and Systemic Lupus Erythematosus in Children—A Development Model of Autoimmune Diseases Starting from What We Inherit to What We Eat
Authors: Lupu Vasile Valeriu , Jechel Elena , Mihai Cristina Maria , Mitrofan Elena Cristina , Lupu Ancuta , Starcea Iuliana Magdalena , Fotea Silvia , Mocanu Adriana , Ghica Dragos Catalin , Mitrofan Costica , Munteanu Dragos , Salaru Delia Lidia , Morariu Ionela Daniela , Ioniuc Ileana
Published: May 2023

Celiac disease (CD) and systemic lupus erythematosus (SLE) are two diseases intensively studied in all age groups, with an increasing incidence at the global level, possibly due to the increased awareness of the diseases and their accurate diagnosis and as a consequence of the new research and innovation technologies that have appeared in medicine. The first is a controllable condition found in approximately 1% of the entire population in the form of a reaction to environmental stimuli affecting individuals with genetic susceptibility, causing gluten intolerance, gastrointestinal and extradigestive symptoms, starting from subclinical stages and culminating in severe malabsorption. On the other hand, lupus is an autoimmune disease with chameleon-like symptoms and found mainly in the female sex, which leaves its clinical mark on most organs, from the skin, eyes, and kidneys to the cardiovascular, pulmonary, neurological, osteoarticular, and hematological systems. Current studies focus on the correlation between celiac disease and other autoimmune pathologies such as autoimmune thyroiditis (Hashimoto and Graves–Basedow), type I diabetes, and systemic lupus erythematosus. The current review aims to present a summary of the data from the specialized literature regarding the intercurrents between celiac disease and lupus by analyzing the most recent studies published on PubMed.
Contribution of Fruits and Vegetables to the Household Food Security Situation of Rural Households in Limpopo
Authors: Sithole Zoleka , Siwela Muthulisi , Ojo Temitope Oluwaseun , Hlatshwayo Simphiwe Innocentia , Kajombo Richard Jack , Ngidi Mjabuliseni Simon Cloapas
Published: May 2023

Food insecurity continues to be a burden for many South Africans. The production and consumption of fruits and vegetables have a potential role in improving household food security and are considered one of the critical pathways for reducing food insecurity and malnutrition levels in the country. This paper set out to determine the effect of fruits and vegetables on the food security status of rural households in the Limpopo province. Data (secondary) for this study were collected from 2043 respondents who were selected through stratified random selection based on the population size of the district municipalities in Limpopo. This study used a quantitative research approach, and data were analyzed using a descriptive analysis, the household food insecurity access scale (HFIAS), and a Poisson regression model with an endogenous treatment model. The findings revealed that gender and involvement in agricultural production had a positive significant relationship with the consumption of fruits and vegetables, while disability grants had a negative impact. Age, household size, and receiving a disability grant had a positive significant impact on determining the household food insecurity status; however, gender had a negative significant relationship. This study concluded that the consumption of fruits and vegetables considerably influenced the food security status of the household. There is a need for government officials and local leaders to provide food security interventions that prioritize women and elders. These may include promoting household production and consumption of diversified fruits and vegetables.
Lifestyle and Dietary Patterns during the COVID-19 Lockdown in Bahrain: A Web-Based Cross-Sectional Study
Authors: Ahmed Jamil , AlSaleh Aseel , Almarabheh Amer J. , Ismail Leila Cheikh , Almuqahwi Aysha A. M. , AlOmer Hussa W. A. , AlAlhareth Ibrahim M. , Albader Sabiha J. M. , Alhajeri Saad S. , Al Dhaheri Ayesha S.
Published: May 2023

Lifestyle factors such as dietary habits, perceived weight, sleep, and physical activity worsened during the COVID-19 pandemic. Through this study, we aimed to understand the impact of COVID-19 on these lifestyle factors in Bahrain. A cross-sectional study was conducted among 1005 adult Bahrainis. Data were collected online using a structured and validated questionnaire for the assessment of eating habits, physical activity, and lifestyle during the COVID-19 pandemic. Participants were snowballed through those who agreed to answer the online questionnaire. There was a higher consumption of fast food, and a higher dependence on takeaways during the COVID-19 pandemic. About 63.5% of the participants consumed >4 meals per day, compared to 36.5% before the COVID-19. About 30% reported consumption of sugar sweetened beverages from two to three times a day. Weight loss was predominantly observed in persons exercising 1–3 times a week. The consumption of sugar-sweetened beverages was also high, with about 19% reporting drinking sweet beverages once every day, 10.6% from two to three times a day, and 40.4% from one to four times a week. A higher proportion of the participants reported poor sleep quality during the pandemic (31.2%) compared to before (12.2%), and 39.7% of the participants reported feeling lazy. Screen time use also doubled during the pandemic, with participants spending more than five hours per day on screens for entertainment, which went from 22.4% before to 51.9% during the pandemic. The lifestyle and dietary habits changed drastically for our study participants during the pandemic. The increased reliance on processed fast food instead of healthier options is a challenge to be tackled in any future pandemic situation. Future research needs to focus on strategies to promote healthier lifestyle modifications during situations such as the COVID-19 pandemic.
Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors
Authors: Sapian Syaifuzah , Ibrahim Mze Asma Ali , Jubaidi Fatin Farhana , Mohd Nor Nor Anizah , Taib Izatus Shima , Abd Hamid Zariyantey , Zainalabidin Satirah , Mohamad Anuar Nur Najmi , Katas Haliza , Latip Jalifah , Jalil Juriyati , Abu Bakar Nur Faizah , Budin Siti Balkis
Published: May 2023

Cardiovascular diseases (CVDs) represent a broad spectrum of diseases afflicting the heart and blood vessels and remain a major cause of death and disability worldwide. CVD progression is strongly associated with risk factors, including hypertension, hyperglycemia, dyslipidemia, oxidative stress, inflammation, fibrosis, and apoptosis. These risk factors lead to oxidative damage that results in various cardiovascular complications including endothelial dysfunctions, alterations in vascular integrity, the formation of atherosclerosis, as well as incorrigible cardiac remodeling. The use of conventional pharmacological therapy is one of the current preventive measures to control the development of CVDs. However, as undesirable side effects from drug use have become a recent issue, alternative treatment from natural products is being sought in medicinal plants and is gaining interest. Roselle (Hibiscus sabdariffa Linn.) has been reported to contain various bioactive compounds that exert anti-hyperlipidemia, anti-hyperglycemia, anti-hypertension, antioxidative, anti-inflammation, and anti-fibrosis effects. These properties of roselle, especially from its calyx, have relevance to its therapeutic and cardiovascular protection effects in humans. This review summarizes the findings of recent preclinical and clinical studies on roselle as a prophylactic and therapeutic agent in attenuating cardiovascular risk factors and associated mechanisms.
Biomimetic Theranostic Agents with Superior NIR-II Photoacoustic and Magnetic Resonance Imaging Performance for Targeted Photothermal Therapy of Prostate Cancer
Authors: Liu Ling , Yang Shangpo , Zheng Ziliang , Li Qingshuang , Liu Chenchen , Hu Dehong , Liu Zhou , Zhang Xiaoping , Zhang Ruiping , Gao Duyang
Published: May 2023

The accurate diagnosis and treatment of prostate cancer at an early stage is crucial to reduce mortality rates. However, the limited availability of theranostic agents with active tumor-targeting abilities hinders imaging sensitivity and therapeutic efficiency. To address this challenge, we have developed biomimetic cell membrane-modified Fe2O3 nanoclusters implanted in polypyrrole (CM-LFPP), achieving photoacoustic/magnetic resonance dual-modal imaging-guided photothermal therapy of prostate cancer. The CM-LFPP exhibits strong absorption in the second near-infrared window (NIR-II, 1000–1700 nm), showing high photothermal conversion efficiency of up to 78.7% under 1064 nm laser irradiation, excellent photoacoustic imaging capabilities, and good magnetic resonance imaging ability with a T2 relaxivity of up to 48.7 s−1 mM−1. Furthermore, the lipid encapsulation and biomimetic cell membrane modification enable CM-LFPP to actively target tumors, leading to a high signal-to-background ratio of ~30.2 for NIR-II photoacoustic imaging. Moreover, the biocompatible CM-LFPP enables low-dose (0.6 W cm−2) photothermal therapy of tumors under 1064 nm laser irradiation. This technology offers a promising theranostic agent with remarkable photothermal conversion efficiency in the NIR-II window, providing highly sensitive photoacoustic/magnetic resonance imaging-guided prostate cancer therapy.
Biopharmaceutical Assessment of Mesh Aerosolised Plasminogen, a Step towards ARDS Treatment
Authors: Vizzoni Lucia , Migone Chiara , Grassiri Brunella , Zambito Ylenia , Ferro Baldassare , Roncucci Paolo , Mori Filippo , Salvatore Alfonso , Ascione Ester , Crea Roberto , Esin Semih , Batoni Giovanna , Piras Anna Maria
Published: May 2023

Acute respiratory distress syndrome (ARDS) is a severe complication of lung injuries, commonly associated with bacterial, fungal and viral infections, including SARS-CoV-2 viral infections. ARDS is strongly correlated with patient mortality and its clinical management is very complex, with no effective treatment presently available. ARDS involves severe respiratory failure, fibrin deposition in both airways and lung parenchyma, with the development of an obstructing hyaline membrane drastically limiting gas exchange. Moreover, hypercoagulation is related to deep lung inflammation, and a pharmacological action toward both aspects is expected to be beneficial. Plasminogen (PLG) is a main component of the fibrinolytic system playing key roles in various inflammation regulatory processes. The inhalation of PLG has been proposed in the form of the off-label administration of an eyedrop solution, namely, a plasminogen-based orphan medicinal product (PLG-OMP), by means of jet nebulisation. Being a protein, PLG is susceptible to partial inactivation under jet nebulisation. The aim of the present work is to demonstrate the efficacy of the mesh nebulisation of PLG-OMP in an in vitro simulation of clinical off-label administration, considering both the enzymatic and immunomodulating activities of PLG. Biopharmaceutical aspects are also investigated to corroborate the feasibility of PLG-OMP administration by inhalation. The nebulisation of the solution was performed using an Aerogen® SoloTM vibrating-mesh nebuliser. Aerosolised PLG showed an optimal in vitro deposition profile, with 90% of the active ingredient impacting the lower portions of a glass impinger. The nebulised PLG remained in its monomeric form, with no alteration of glycoform composition and 94% of enzymatic activity maintenance. Activity loss was observed only when PLG-OMP nebulisation was performed under simulated clinical oxygen administration. In vitro investigations evidenced good penetration of aerosolised PLG through artificial airway mucus, as well as poor permeation across an Air–Liquid Interface model of pulmonary epithelium. The results suggest a good safety profile of inhalable PLG, excluding high systemic absorption but with good mucus diffusion. Most importantly, the aerosolised PLG was capable of reversing the effects of an LPS-activated macrophage RAW 264.7 cell line, demonstrating the immunomodulating activity of PLG in an already induced inflammatory state. All physical, biochemical and biopharmaceutical assessments of mesh aerosolised PLG-OMP provided evidence for its potential off-label administration as a treatment for ARDS patients.
Influence of Polymer Concentration on Drying of SPION Dispersions by Electrospinning
Authors: Dragar Črt , Rekar Žan , Potrč Tanja , Nemec Sebastjan , Kralj Slavko , Kocbek Petra
Published: May 2023

To improve the physical stability of nanoparticle dispersions, several methods for their transformation into stable and easily dispersible dry products have been investigated thus far. Recently, electrospinning was shown to be a novel nanoparticle dispersion drying method, which addresses the crucial challenges of the current drying methods. It is a relatively simple method, but it is affected by various ambient, process, and dispersion parameters, which impact the properties of the electrospun product. The aim of this study was, thus, to investigate the influence of the most important dispersion parameter, namely the total polymer concentration, on the drying method efficiency and the properties of the electrospun product. The formulation was based on a mixture of hydrophilic polymers poloxamer 188 and polyethylene oxide in the weight ratio of 1:1, which is acceptable for potential parenteral application. We showed that the total polymer concentration of prior-drying samples is closely related to their viscosity and conductivity, also affecting the morphology of the electrospun product. However, the change in morphology of the electrospun product does not affect the efficiency of SPION reconstitution from the electrospun product. Regardless of the morphology, the electrospun product is not in powder form and is therefore safer to handle compared to powder nanoformulations. The optimal total polymer concentration in the prior-drying SPION dispersion, which enables the formation of an easily dispersible electrospun product with high SPION-loading (65% (w/w)) and fibrillar morphology, was shown to be 4.2% (w/v).
Robust Inclusion Complex of Topotecan Comprised within a Rhodamine-Labeled β-Cyclodextrin: Competing Proton and Energy Transfer Processes
Authors: Di Nunzio Maria Rosaria , Douhal Abderrazzak
Published: May 2023

Monitoring the biological fate of medicaments within the environments of cancer cells is an important challenge which is nowadays the object of intensive studies. In this regard, rhodamine-based supramolecular systems are one of the most suitable probes used in drug delivery thanks to their high emission quantum yield and sensitivity to the environment which helps to track the medicament in real time. In this work, we used steady-state and time-resolved spectroscopy techniques to investigate the dynamics of the anticancer drug, topotecan (TPT), in water (pH ~6.2) in the presence of a rhodamine-labeled methylated β-cyclodextrin (RB-RM-βCD). A stable complex of 1:1 stoichiometry is formed with a Keq value of ~4 × 104 M−1 at room temperature. The fluorescence signal of the caged TPT is reduced due to: (1) the CD confinement effect; and (2) a Förster resonance energy transfer (FRET) process from the trapped drug to the RB-RM-βCD occurring in ~43 ps with 40% efficiency. These findings provide additional knowledge about the spectroscopic and photodynamic interactions between drugs and fluorescent functionalized CDs, and may lead to the design of new fluorescent CD-based host–guest nanosystems with efficient FRET to be used in bioimaging for drug delivery monitoring.
Modeling Lattice Matched Dilute Nitride Triple and Quadruple Junction Solar Cells on Virtual SiGe Substrate
Authors: Navruz Tugba S.
Published: May 2023

A lattice matched triple junction solar cell (TJSC) structure with a GaAs0.58 P0.42 top cell and bandgap tunable GaNxAs1-x-zPz middle and bottom cells on virtual SiGe substrate is proposed in this study. SiGe/Si substrate is preferred as it is a low-cost substrate and because it provides a lattice constant at which bandgap tunable dilute nitride materials that are appropriate for highly efficient multijunction solar cells can be obtained. By changing the nitrogen content in GaNxAs1-x-zPz, the bandgap of the middle and bottom subcells is adjusted to the optimum values. The bandgap of the top cell is constant at 1.95 eV. Three models with different values of surface recombination velocities and Shockley–Read–Hall recombination lifetimes are applied to the presented TJSC structure. Peak efficiencies of 48.9%, 40.6% and 33.7% are achieved at EG2 = 1.45 eV and EG3 = 1.04 eV for Model 1, EG2 = 1.45 eV and EG3 = 1.15 eV for Model 2, and EG2 = 1.5 eV and EG3 = 1.17 eV for Model 3, respectively. A fourth bandgap adjustable GaNxAs1-x-zPz junction is inserted into the system and a significant improvement is obtained under high sun concentration for Models 1 and 2. The presented original results are very promising because the variable bandgaps provide very efficient absorption of incoming spectrum.
Plant Glucosinolate Content and Host-Plant Preference and Suitability in the Small White Butterfly (Lepidoptera: Pieridae) and Comparison with Another Specialist Lepidopteran
Authors: Badenes-Pérez Francisco Rubén
Published: May 2023

Glucosinolates are used in host-plant recognition by insects specialized on Brassicaceae, such as Pieris rapae L. (Lepidoptera: Pieridae). This research investigated the association between P. rapae oviposition and larval survival and host-plant glucosinolate content using 17 plant species in which glucosinolate content had previously been determined. Two-choice oviposition tests (comparing each plant species to Arabidopsis thaliana L.) and larval survival experiments showed that indolic glucosinolate content had a positive effect on oviposition preference and larval survival in P. rapae. In the host plants tested, the effects of indolic glucosinolates on oviposition preference and of glucosinolate complexity index and aliphatic glucosinolates without sulfur-containing side chains on total oviposition were smaller on P. rapae than on Plutella xylostella L. (Lepidoptera: Plutellidae), another lepidopteran specialized on glucosinolate-containing plants. This study suggests that high indolic glucosinolate content could make crop plants more susceptible to both P. rapae and P. xylostella, but this effect seems to be greater for P. xylostella. Additionally, as some differences in oviposition and larval survival between P. rapae and P. xylostella occurred in some individual plants, it cannot be concluded that bottom-up factors are always similar in these two specialist insects.