bluuebunny/crossref_metadata_2025 huggingface dataset:
A rare case of iliopsoas hematoma in a patient with von Willebrand disease
Authors: Kawarat Vikas , Javid Mohamed , Swaminathan Shanthi Ponnandai , Ross Kannan
Published: February 2020

Iliopsoas hematoma is a serious complication that can occur in bleeding disorders, most commonly hemophillia but it can also be seen in von Willebrand disease (vWD) in less frequency. This can cause muscle pain, muscle dysfunction and sometimes even femoral nerve palsy. Iliopsoas hematomas can be diagnosed by the usage of ultrasonography, computed tomography (CT) or magnetic resonance imaging (MRI). Here we report a case of a 20-year-old boy who presented to us with complaints of pain in the right lower quadrant, flank, and inguinal region for a week. He was diagnosed with vWD type 3 when he was 10 years old. The symptoms started after he had tried to kick start his motorbike vigorously. Clinical examination revealed the patient to be in an anti-pain posture and to have tenderness at sites where he complained of pain. A subsequent CT scan showed that there was an iliopsoas hematoma of size 10×6 cm. The patient was managed conservatively with factor replacement and physiotherapy following which there was amelioration in the symptoms and the patient recovered well.
Managing laryngotracheal trauma: 3 year experience at a tertiary hospital in North India
Authors: Munjal Manish , Kaur Japneet , Rishi Porshia , Singh Harjinder , Tuli Nitika , Munjal Shubham
Published: February 2020

Background: Laryngotracheal trauma includes life threatening injuries that are encountered by emergency care physicians, trauma surgeons and ENT surgeons. These injuries can occur in the most remote areas or in the busiest metropolitan setting. Earlier intervention is vital in order to reduce the mortality and morbidity associated with insult to the aerodigestive tract and surrounding structures.

Methods: This is a retrospective study of 21 patients who presented to the emergency department of Dayanand Medical College and Hospital, Ludhiana, for management of injuries to aerodigestive tract over a period of 3 years from January 2016 to December 2019.  

Results: Twenty-one patients were seen with acute injuries to the airway in the emergency department. There were 12 males and 9 female patients out of which there were 10 men and 5 women, 3 girls and 2 boys ranging in age from 9 to 60 years. Although most of these injuries occurred as a result of blunt trauma, 6 were due to penetrating injuries out of which 2 were due to homicidal assault. Stridor was the most common finding followed by surgical emphysema. Twelve patients were in acute respiratory distress requiring emergency procedures to secure the airway. All patients underwent successful repair of the injuries. All patients except 1 had a good airway.

Conclusions: Laryngotracheal injury is rare but very crucial and life-threatening surgical emergency. Timely intervention is crucial in the management of laryngotracheal trauma in order to prevent complications.
A comparative study of endoscopic septoplasty and conventional septoplasty
Authors: Deshmukh Kiran A. , Ambiger Rashmi T.
Published: February 2020

Background: The aim of the study was to study the advantages and disadvantages of endoscopic septoplasty and conventional septoplasty and to co-relate the two procedures in terms of intra-operative visualization, duration of surgery, procedural difficulties, hospital stay and complications.

Methods: It is a prospective study done during November 2017 to April 2019 on 50 patients with symptomatic deviated nasal septum. Patients were randomly divided into conventional septoplasty and endoscopic septoplasty groups of 25 each. Surgery was performed as according to the division. Followed up on 1st week, 15th day, 1st month and 3rd month.  

Results: In endoscopic septoplasty group, septal pathology, precise correction of the pathology, with less complications were seen. Hospital stay and duration of surgery were significantly less in endoscopic group.

Conclusions: For minimal and posterior deviations of the septum, endoscopic septoplasty is better, whereas for anterior deviations, conventional septoplasty could be better choice.
Arthroscopic repair of rotator cuff tears: analysis and functional outcome
Authors: Jacob Rejo V. , Girotra Prateek , Prashanth Kumar K.
Published: February 2020

Background: Rotator cuff injuries are common injuries occurring around the shoulder with an incidence ranging from 5 to 39%. Rotator cuff tears can be either partial thickness or full thickness. If remains untreated, may lead to persistent shoulder pain, functional limitation and decreased quality of life. In the present study, we assess the functional outcome following arthroscopic repair of rotator cuff tears. We also assess the various parameters affecting the functional outcome following repair.

Methods: 15 patients with rotator cuff tears were subjected to this study. Preoperative evaluation of the American Shoulder and Elbow Surgeons (ASES) shoulder score and University of California and Los Angeles (UCLA) shoulder score was done. Arthroscopic rotator cuff repair using single row repair with suture anchors was done. The patients were followed up at 6 weeks, 3 months and 6 months where ASES score and UCLA score were assessed.

Results: Of the 15 patients, 14 had supraspinatus tear, 2 patients had infraspinatus tear and 2 patients had subscapularis tear. According to UCLA scoring system 22% patients had excellent, 43% patients had good results, 23% patients had fair results and 12% patients had poor results. ASES score also showed progressive improvement at subsequent follow ups at 3 and 6 months.

Conclusions: From our present study we conclude that arthroscopic rotator cuff repair is a good modality showing excellent functional outcome with less morbidity, minimal postoperative pain, better cosmesis and early resumption of daily routine activities.

 
Efficacy of ultrathin epidermal grafting followed by narrow band ultraviolet B therapy for stable vitiligo: a novel therapy
Authors: Kamcharla Lakshmi , Tadi Sahitya , Darla Rakesh , Sidhabathuni Nageswaramma
Published: February 2020

Background: Different surgical techniques in the form of tissue or cellular grafting procedures are used alone or in combination with narrow band ultraviolet B (NBUVB) to treat stable vitiligo resistant to medical treatment. The aim of the study was to assess the cosmetic results obtained with combination therapy of ultrathin split-thickness skin grafts and adjuvant NBUVB therapy in resistant, stable vitiligo.

Methods: Forty patients of stable vitiligo were treated with ultrathin split-thickness grafting and the patients were then put on NBUVB therapy. Extent of repigmentation and final cosmetic outcome at the recipient as well as donor sites were assessed.

Results: The initial evidence of repigmentation was noted in the second week after starting NBUVB. Results showed 85% of patients had more than 90% repigmentation and the overall cosmetic results at the recipient site was good to excellent in 90% patients at the end of NBUVB treatment. Perigraft halo of depigmentation was seen in five patients (12%) on the recipient site. Hypertrophic scarring was seen in two patients at the donor site.

Conclusions: Ultrathin split-thickness skin grafting, when combined with NBUVB therapy, leads to better cosmetic outcome with faster onset of repigmentation in resistant and stable vitiligo.
Tactile Collider: A new approach to the communication of fundamental science to visually impaired people
Authors: Appleby Rob , Edmonds Chris , Watson Robyn
Published: February 2020

There is a large public interest in topics such as the Large Hadron Collider and the Higgs boson, primarily communicated to school children and the wider public using visual methods. As a result, visually impaired audiences of all ages often have difficulty accessing the scientific
communication and may not be culturally involved in the scientific process. Tactile Collider aims to address this issue and has developed new methods of engaging visually impaired children and adults in science by the creation of the Tactile Collider model. This model has been developed with
visual impairment (VI) experts and consultations, and implemented in a national touring event called Tactile Collider, visiting VI schools and centres around the country between 2017 and 2019. This paper describes the model and its development, and the use of the model to curate Tactile Collider
events in 2017 and 2018. We present a quantitative and qualitative analysis of three 2018 events, showing the effectiveness of the approach and the engagement of the audience. The broader applicability is discussed.
Empatía y Diseño en un contexto de inmigración
Authors: Martinez Azaro Victoria
Published: February 2020

Elaborando sobre conceptos del lenguaje como elemento que construye, constituye, forma y determina valores personales y sociales, este artículo cuestiona ideas en cuanto a la producción creativa y su relación con procesos sustentables de empatía. Adoptando una mirada de auto reflexión sobre la base de elementos presentes en la producción de la obra de la autora, como diseñadora de Indumentaria y artista plástica, se pone en evidencia la tensión y conflicto entre sentimientos de dislocación y su relación con intereses teóricos que han informado los procesos creativos de la autora. Una exploración teórica a su producción creativa como inmigrante Latina en Nueva Zelanda y el desplazamiento en cuanto a su autopercepción informan la base de este escrito.
Diseño de indumentaria: Nuevas estrategias de enseñanza y modelos de innovación en el marco del consumo de moda
Authors: Fiorini Verónica
Published: February 2020

Este artículo se propone abordar ciertos cambios en los modelos metodológicos que se desarrollan en el campo de la enseñanza del proyecto en indumentaria. El impacto de las transformaciones socioculturales en los modelos de consumo, la emergencia de otras lógicas de producción de los mensajes y discursos comunicacionales en el campo de la moda son aspectos que obligan a revisar las concepciones disciplinares en la educación en diseño y en el campo profesional. Hay dos aspectos claves que se analizarán en este trabajo: los modos de pensar y enseñar el diseño y sus objetos resultantes en su relación con las experiencias de consumo que proponen en tanto valor-signo (Baudrillard). El contexto contemporáneo, incierto y fluctuante también traza un panorama de alta complejidad. La emergencia de las identidades locales, en un mundo altamente globalizado, merece ser revisado, en tanto redefine la lógica del campo disciplinar (Bourdieu) y los discursos que son legitimados en el mismo (Verón).
Fases y redes en la metodología del Design Thinking
Authors: Ketlun María del Mar
Published: February 2020

En nuestro mundo de formas y dentro de la profesión del diseño existe un universo que nos rodea, que rota constantemente, una especie de mapa de constelaciones creado por diversos puntos que parecen ser todos centrales. Pensándolo desde figuras geométricas, notamos que tienen significado en sí mismas, y encontramos en ellas personas, objetos e ideas, triángulo que gira motivado por las ganas de crear significados. La disciplina del diseño actualmente intenta estar un paso al frente en cuanto a innovación se trata, y nos encontramos frente a la pregunta ¿cómo innovamos si nos dicen que todo está inventado? La respuesta podrá ser: lo inventado puede reinventarse. Para comprobar esto, se recorren distintas formas y áreas visuales, entrecruzando estas constelaciones con diversas técnicas para motivarnos a crear desde el Design Thinking, utilizando lo que percibimos y conocemos, logrando representar conceptos y estableciendo una correspondencia entre los componentes del problema según características estructurales, superficiales, objetivos del razonador y exigencias del entorno, con “personas” como factor clave en la metodología del Design Thinking, para lograr salir de la idea de uno mismo y generar empatía con la gente.
La evolución de los modelos de enseñar-aprender diseño en el nuevo escenario generacional
Authors: Galbusera Testa Carmen Inés
Published: February 2020

El enseñar-aprender diseño plantea desafíos en el contexto del paradigma global actual. Las generaciones de Baby-Boomers (1945-60) y X (1961-79), formadas en tiempos de guerra fría, son los organizadores didácticos de las generaciones NET o de nativos digitales: Millenials (1980-1993), Z (1994-2009) y Touch (2010-hoy). Los cambios cuantitativos y cualitativos se producen a velocidad acelerada en las dimensiones económicas, políticas, sociales, ambientales, tecnológicas y simbólicas desde fines del S.XX e inicios del XXI. Nuevas modalidades de enseñanza/aprendizaje producto de cambios generacionales, invitan a la reflexión crítica.
A World in Flux. Introduction
Authors: Faerm Steven
Published: February 2020

El estado actual del mundo está en movimiento. A nivel mundial, las comunidades y las personas están experimentando cambios tremendos, inestabilidad, transición, movilidad e incertidumbre. En medio de este tenue futuro, ¿cómo responden los artistas, los diseñadores y los educadores? Cómo podemos preparar y fortalecer nuestro futuro a través de medios pragmáticos o teóricos? ¿Cuál es el papel del diseño, el diseñador y la educación del diseño en estados de flujo tan pronunciados? Es con este deseo de examinar, cuestionar y proponer nuevos conocimientos sobre el estado actual de flujo global que presentamos a nuestra revista. Los autores consideran el paisaje contemporáneo desde perspectivas diversas y ofrecen especulaciones y perspectivas en pedagogía, desarrollo estudiantil, educación de diseño, emprendimiento, economía, sistemas de diseño, globalización / localización, sostenibilidad, medios comerciales, sociología y práctica / industria del diseño.
China: Hyper-Consumerism, Abstract Identity
Authors: Cyr Marie Genevieve
Published: February 2020

Es el siglo 21 el siglo chino? La occidentalización ha cambiado casi todas las facetas de la vida en China, a excepción de la política (Wu, 2009). Esto ha creado confusión masiva, entusiasmo, rebelión, romanticismo e idealismo. Las industrias manufactureras de la década de 1990 continuaron dominando la aceleración del consumismo en el siglo XXI y crearon, más que nunca, un mundo de identidad extrañamente gigante y abstracto que se auto creó y se mantuvo. Este artículo examina la política del deseo abstracto, el hiper consumismo y la noción de fantasía en la industria de la moda china. Hoy, cientos de “hipermercados” gigantes que se encuentran en toda China están dedicados a la distribución de “cosas” falsas. Estos emblemas comerciales se han convertido en una parte integral del paisaje visual y social de China. El mercado de productos falsificados que utilizan imá- genes de marcas occidentales (ej., logotipos) ha crecido durante siglos hasta convertirse en una gran estructura abstracta de estilos de vida con marcas falsas y diseño integral. El aumento global del hiperconsumo le dio a China la última oportunidad de crear una nueva identidad para sí misma mientras se importa el sueño del lujo: The Buying Power. Este documento se centra en abstraer la noción de hiperconsumismo e interrogar la relación entre la publicidad visual, su materialidad y su representación en el mercado global. ¿Cómo contribuye la publicidad a la producción de bienes de consumo? ¿Podemos crear una visión cíclica de nuevos materiales? ¿Cómo se crea, se desplaza, se transforma y se consume el valor del lujo a través del espacio y el tiempo?
Immersion in the Workplace: A Unique Model for Students to Engage in Real-World Service Design
Authors: Sebek Anezka , Jones John
Published: February 2020

Desde 2015, Fjord and Parsons School of Design han estado colaborando para crear una alternativa mutuamente beneficiosa para el sistema de pasantías, al sumergir a los estudiantes de posgrado en Diseño y Tecnología en los Estudios de Diseño Inmersivo de Fjord, durante una semana. Los Estudios de Diseño en Fjord operan desde el trabajo directo con el cliente y son un vehículo perfecto para involucrar a los estudiantes en la investigación de diseño estructurado, centrado en el ser humano. La misión del programa de inmersión Fjord / Parsons es influir en el futuro del diseño, dar forma a los futuros diseñadores y propulsar la innovación en el diseño de servicios de Fjord. Para los estudiantes de Parsons, la experiencia como miembros contribuyentes de un equipo de diseño de servicios es un beneficio inusual. Mientras que los programas de pasantías tradicionales de meses pueden ser una carga para los recursos de la compañía o una experiencia de aprendizaje improductiva para los estudiantes, el Programa de inmersión Fjord / Parsons es una excelente oportunidad y una alternativa de capacitación para involucrar a los estudiantes en un trabajo significativo, logrando así una investigación valiosa de diseño para Fjord. Este documento analiza seis casos de estudiantes graduados de Parsons que se beneficiaron con este programa.
On Vibrational and Dynamic Characteristics of Engines with Deactivated Cylinders
Authors: Yamanin A.I.
Published: February 2020

The article examines some features of dynamics of engines with shut-off cylinders. This technology can promote reduction of fuel consumption and emission of toxic substances with exhaust fumes at partial speed and loading modes. However, the dynamics of such engines have hardly been considered in previous works. Using calculations (solid state modeling, simulation of motion using software for studying dynamics of mechanisms, as well as the finite element method), the indicators of uniformity of stroke and torque, vibration displacement and vibration velocity of various points of the structure at low- and high-frequency vibration are determined. It is shown that when deactivating a different number of cylinders, the uniformity of the engine torque worsens (to a varying degree) and the load on the crankshaft bearings increases. The average quadratic values of vibration velocity of the bearings at low-frequency vibration and the vibration velocity of the lateral walls of the housing parts at high-frequency vibration increases as well. While engines with deactivated cylinders definitely have advantages in efficiency and environmental performance, they do not improve vibrational and dynamic characteristics, which is particularly evident at low rotational speeds of the shaft and at small loads.
The Selection of Parameters and Design of an Air Turbine Unit for Flue Gas Heat Recovery of a 16 MW Gas Turbine Unit for Gas Pumping Units
Authors: Manushin E.A. , Melnikov A.I.
Published: February 2020

The introduction of combined turbine units is a promising method to increase fuel efficiency (pumped natural gas) and improve the environmental performance of the gas turbine units (GTU) that are used to drive superchargers of gas pumping units (GPU). Such an installation consists of the main GTU operating on natural gas and an additional air turbine unit (ATU). The latter utilizes the heat of the combustion products leaving the gas turbine unit in a heat exchanger, behind which cooled air is mixed with flue gases. The efficiency of heat recovery is determined by solving a complex technical and economic problem of selecting the optimal weight-and-size parameters of the heat exchanger. When retrofitting a gas pumping unit, it is advisable to use a GTU that is slightly different in design and parameters as the basic gas turbine unit. The ATU does not have an operating equivalent. Its parameters should ensure achieving the maximum fuel efficiency factor of the combined installation, with acceptable weight-and-size parameters of the ATU and the heat exchanger. As an example of developing the GTU-ATU type installations, an option of modernizing a GTU for a 16 MW GPU is proposed, which constitutes the basis of the Gazprom fleet. A combined GTU-ATU is designed to include the main 16 MW GTU and an additional 1 MW ATU to drive the electric generator. The fuel efficiency factor of the GTU-ATU installation reaches 39.3%. The design of the developed ATU is simple and reliable. Plate-ribbed surfaces PlR-2/PlR-2 are used to achieve the optimum mass-and-weight and hydraulic parameters of the heat exchange. A layout of the units of the combined installation is proposed, in which acceptable hydraulic resistance in the pipelines is provided. The feasibility study shows that the project is economically feasible. The environmental effect of modernization using an ATU is characterized by a significant decrease in the temperature of flue gases and concentration of harmful emissions by 1.3 times.
EVALUATION OF HYPERGLYCEMIA IMPACT ON OUTCOMES OF ACUTE CORONARY SYNDROME IN ELDERLY AND SENILE PATIENTS
Authors: Pushkin A. S. , Akhmedov T. A. , Volchkov V. A. , Rukavishnikova S. A. , Kim S. V.
Published: February 2020

Acute coronary syndrome (ACS) in elderly and senile patients has a number of features and requires special attention to providing medical care. These patients is associated with significant comorbidity and atypical symptoms in the course of the disease. Diabetes mellitus is a common background disease in patients with ACS.A retrospective cohort study was performed, 2945 patients with ACS were examined. Patients were divided into three age groups: group 1 - patients aged 18 to 63 years; group 2 - patients aged 64 to 75 years; group 3 - patients older than 75 years. Number of patients with glucose concentrations above 11.1 mmol/L is significantly higher in elderly and senile groups than in group of patients from 35 to 59 years old. The number of patients with impaired renal function after administration of a contrast medium in the study group with ACS increased with increasing age. Significant difference was revealed between the middle and senile age groups, as well as between the elderly and senile age groups. An increase in the relative number of patients with fatal outcomes in groups with a significant increase in glucose levels was revealed. The connection between the pathological level of glucose and repeated myocardial infarction is proved. Conclusion. The presented statistical picture suggests a particularly high risk of recurring cardiovascular events among patients with ACS and pathological glucose levels. The correlation between the number of deaths and glucose levels during the initial examination allows the use of glucose tests as an additional criterion in the stratification of risks and outcomes in patients with ACS.
Control bio-inspirado para un actuador elástico por medio del algoritmo de aprendizaje por retroalimentación del error
Authors: González-Vargas José , Rios-Mora Mario , Moreno Juan C. , Pons-Rovira José Luis
Published: February 2020

El presente documento abarca la mejora del esquema de control de los actuadores de rigidez variable (VSA), presentes en la articulación de la rodilla de un robot bípedo llamado Binocchio, desarrollado por el grupo de Neuro-rehabilitación del Instituto Cajal. El diseño de dicho robot se basó en varias características biológicas presentes en los seres humanos como por ejemplo la visco-elasticidad de los músculos. Para controlar estos actuadores de manera robusta y eficiente no es suficiente el uso de estrategias de control clásico basados en modelos, debido a que estos métodos no son capaces de tomar en cuenta todas las no-linealidades intrínsecas del actuador debido a su estructura mecánica y a su naturaleza elástica. Por ello se adaptó un método bio-inspirado de control conocido como Feedback Error Learning (FEL) que utiliza una red neuronal para aprender el modelo inverso sin ningún conocimiento a priori de los parámetros del actuador. Seguidamente se procedió a realizar pruebas de control para validar su implementación. Finalmente, fue posible adaptar el FEL para el control de los VSA, lo que incidió en una mejora significativa en el rendimiento de los controladores de trayectoria. Pruebas de robustez y de estabilidad permitieron validar el uso del FEL como una alternativa viable para el control de los actuadores.
Importancia de los recursos interpretativos autoguiados, como promotores de la conservación de los recursos naturales
Authors: Calvo-Vargas Indira María
Published: February 2020

La Interpretación Ambiental es una rama de la Educación Ambiental no formal caracterizada por revelar la importancia de un significado. Intenta crear un sentido de pertenencia en la audiencia y facilita un mensaje poderoso, capaz de incentivar a un cambio de comportamiento en el público y revelando la importancia de la conservación del recurso interpretado. La interpretación ambiental tiene sus inicios a finales del siglo XIX con la creación de parques nacionales en América del Norte. En América Latina, se realiza Interpretación Ambiental en las Islas Galápagos desde 1960, mientras que en Costa Rica surge de la mano de la creación de las primeras Áreas Silvestres Protegidas en la década de 1970. A pesar del poco desarrollo conceptual y material bibliográfico disponible, la Interpretación Ambiental ha venido abriéndose paso como facilitadora del mensaje de la conservación del recurso natural y cultural en el país, a través de diferentes recursos interpretativos. En nuestro país, el Parque Nacional Volcán Poás utilizó exitosamente la Interpretación Ambiental como herramienta para la conservación. Asimismo el Parque Nacional Carara ha desarrollado recursos interpretativos accesibles para todo tipo de público sin importar su edad, formación académica o capacidad especial, gracias a la creación en el año 2012 de un sendero universal. Por tanto, este artículo busca informar al lector acerca de la IA desde su significado conceptual hasta sus orígenes en el campo nacional e internacional y se muestran ejemplos de casos representativos de instrumentos interpretativos en el país, demostrando la importancia de estos recursos como promotores de la conservación del recurso natural.
Inmovilización de la proteína fotoactiva bacteriorodopsina sobre óxido de zinc Aplicación en Celdas Solares Bio-Sensibilizadas
Authors: Martínez-Brenes Alejandro , Chaves-Villarreal Claudia
Published: February 2020

En este proyecto se construyeron fotoánodos para celdas solares sensibilizadas utilizando la proteína fotoactiva bacteriorodopsina (BR). El objetivo fue utilizar la proteína como sustituyente a los colorantes comunes a base de Ru, que son costosos y tóxicos. Los sustratos se prepararon recubriendo vidrio conductor con nanopartículas de óxido de zinc (ZnO-NPs). La proteína se inmovilizó en estos sustratos para completar un fotoánodo capaz de capturar la energía solar y transformarla en energía eléctrica. Las técnicas de dropcasting (DC), funcionalización química con feniltrietoxisilano (PTES) y la sedimentación electroforética (SE) fueron optimizadas para inmovilizar la proteína. Mediante espectroscopia de absorción ultravioleta-visible (UV-Vis) se demostró que la proteína conservaba su función fotoactiva después de la inmovilización. La resistencia y tasa de transferencia de carga del fotoánodo en el electrolito fue comparada por medio de impedancia electroquímica. Para los tres métodos se encontraron valores relativamente altos (105 Ω) en comparación con datos reportados para tintes de rutenio. El desempeño de los fotoánodos preparados por DC y SE en celdas solares sensibilizadas se determinó por cronopotenciometría bajo iluminación. Se encontró que la capa molecular de PTES permite inmovilizar la proteína en periodos más cortos de tiempo pero introduce una resistencia eléctrica adicional en el sistema, por lo que no es apropiada para el sistema fotoelectroquímico estudiado. Los fotoánodos preparados por SE permite obtener el fotovoltaje más alto (16 mV) y la tasa de transferencia electrónica más veloz, mientras que usando la técnica DC se midieron fotovoltajes de tan solo 1 mV. Estas respuestas sugieren que la orientación de la proteína en el ZnO es determinante en la fotorespuesta de la celda, ya que bajo el campo eléctrico aplicado durante SE la proteína se orienta según su dipolo eléctrico, mientras en el DC, la orientación es aleatoria. En base a los resultados obtenidos, se recomienda controlar mejor el espesor de la capa de la proteína, utilizar un electrolito más afín a la naturaleza de esta biomolécula y disminuir la rugosidad de la capa de ZnO para producir fotoánodos que transformen la energía solar de forma más eficiente.
A onipresença da essência dos princípios de processo sob a perspectiva da metafísica
Authors: Ferrão André Munhoz de Argollo , Cezare José Felicio Ribeiro De
Published: February 2020

Por uma abordagem sistêmica, transdisciplinar e orientada a processos, este texto foi desenvolvido para apresentar a presença inerente da essência de princípios de processo nas áreas de conhecimento como Ciências Humanas e Ciências Exatas. Devido as suas diferenças na percepção de como a realidade pode ser, este trabalho apresenta a ligação de um processo físico - exemplificando a produção de um objeto - com um processo metafísico, demonstrado pelos sistemas de crenças e filosofias do budismo tibetano e do budismo zen. Estabelecendo-se a relação entre os processos físicos e metafísicos mediante alguns dos princípios utilizados durante as aulas de Abordagem Sistêmica e Pensamento orientado a processos, inspirados nos princípios que orientam os estudos da Sociedade Europeia para o Pensamento do Processo. Agregando o pensamento de Whitehead, Russell, Jung, Sidarta, Morin e Krishnamurti.
Implementación y uso de software libre para la docencia de la fotogrametría en el ámbito universitario = Implementation and use of free software for the teaching of photogrammetry in the University field
Authors: López-Medina José Antonio , Pérez Zapata Carlos , Martin Romero Jose Luis
Published: February 2020

En la docencia de una disciplina tan específica, como lo es la fotogrametría terrestre y aérea, es común mostrar al alumno programas con los que realizar las tareas encomendadas en clase. Usualmente, estos programas de pago tienen un coste muy elevado, tanto para la universidad como para el alumno, que no permite acceder más que a demos limitadas en el tiempo y en la exportación de resultados. Con el presente trabajo, ponemos de manifiesto que es relativamente sencillo implementar un método de docencia basado en los softwares libres, que mostraran al alumno el camino para iniciarse en la fotogrametría y resolver todas las tareas de su formación como profesional.AbstractIn the teaching a specific discipline, such as terrestrial and aerial photogrammetry, it is common to show the student programs with which to perform the tasks entrusted to the class. Usually, these payment programs have a very high cost, both for the university and for the student, who cannot access more than demos limited in time and in the export of results. With the present work, we show that it is relatively easy to implement a teaching method based on free software, which will show the student the path he starts in photogrammetry, and with whose use he can start and solve all the tasks of his training as engineer
Assédio Moral como estratégia de gestão no serviço público
Authors: Schlindwein Vanderleia Dal Castel
Published: February 2020

Este artigo tem como objetivo desvelar os novos mecanismos de gestão da administração pública contemporânea: a utilização do assédio moral como estratégia de gestão. As mudanças em cena são baseadas na excelência e produtividade, engajam todos os trabalhadores aos valores e interesses da instituição, por meio das normas, metas, sistemas de controle e avaliações dos processos. O estudo, de caráter qualitativo, baseou-se em cinco depoimentos de trabalhadores que tiveram histórias de afastamento no trabalho por transtornos mentais e comportamentais e duas entrevistas com gestores de uma instituição pública. Como procedimento ético, foi apresentado o Termo de Consentimento Livre e Esclarecido/TCLE, bem como o estudo foi aprovado pelo Comitê de Ética em Pesquisa da universidade. Como análise, as entrevistas foram interpretadas com base na análise temática. Conclui-se que as novas ferramentas de gestão impõem uma violência simbólica, difusa e gradual, submete os trabalhadores voluntariamente à nova ordem de gerenciamento por meio de mecanismos de controle e coerção caracterizando assédio moral.
AGTR2, One Possible Novel Key Gene for the Entry of 2019-nCoV into Human Cells
Authors: Cui Qinghua , Cui Chunmei , Huang Chuanbo , Zhou Wanlu , Ji Xiangwen , Zhang Fenghong , Wang Liang , Zhou Yuan
Published: February 2020

Recently, it was confirmed that ACE2 is the receptor of 2019-nCoV, the pathogen causing the recent outbreak of severe pneumonia in China. It is confused that ACE2 is widely expressed across a variety of organs and is expressed moderately but not highly in lung, which, however, is the major infected organ. It remains unclear why it is the lung but not other tissues among which ACE2 highly expressed is mainly infected. We hypothesized that there could be some other genes playing key roles in the entry of 2019-nCoV into human cells. Here we found that AGTR2 (angiotensin II receptor type 2), a G-protein coupled receptor, has interaction with ACE2 and is highly expressed in lung with a high tissue specificity. More importantly, simulation of 3D structure based protein-protein interaction reveals that AGTR2 shows a higher binding affinity with the Spike protein of 2019-nCov than ACE2 (energy score: -15.7 vs. -6.9 [kcal/mol]). Given these observations, we suggest that AGTR2 could be a putative novel gene for the the entry of 2019-nCoV into human cells but need further confirmation by biological experiments. Finally, a number of compounds, biologics and traditional Chinese medicine that could decrease the expression level of AGTR2 were predicted.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF PADU PADAN UNTUK MENINGKATKAN HASIL DAN EFEKTIFITAS BELAJAR PADA MATA PELAJARAN AUTOCAD KELAS XI TEKNIK GAMBAR BANGUNAN DI SMK NEGERI 5 SURAKARTA TAHUN ANGKATAN 2015/2016
Authors: Ratnasari Listiyani Desy , Rahmawati Anis , Roemintoyo Roemintoyo
Published: February 2020

Tujuan penelitian ini adalah untuk memperoleh peningkatan hasil belajar dan efektifitas belajar siswa dalam mata pelajaran AutoCad setelah dilakukan penerapan pembelajaran kooperatif padu padan antara tipe Student TeamsAchievment Divisions (STAD), Make a Match, dan Numbered Heads Together (NHT) pada Kelas XI Teknik Gambar Bangunan SMK Negeri 5 Surakarta tahun angkatan 2015/2016. Penelitian ini merupakan penelitian tindakan kelas. Penelitian ini dilaksanakan dalam 2 siklus. Sumber data berasal dari guru dan peserta didik. Teknik pengumpulan data dengan metode observasi, dokumentasi, tes, dan wawancara. Hasil penelitian disimpulkan bahwa, (1) penggunaan model pembelajaran padu padan dapat meningkatkan hasil belajar siswa pada ranah kognitif, persentase ketuntasan pra tindakan 54,84%, pada siklus I 61,54%, sedangkan pada siklus II meningkat menjadi 81,48%, (3) Ranah afektif pada pra tindakan, siswa yang mendapat predikat baik (B) sebanyak 64,5% pada siklus I meningkat menjadi 84,61%, pada siklus II mengalami peningkatan 92,59% berpredikat baik (B), (4) Ranah Psikomotorik juga mengalami peningkatan yaitu pada pra tindakan persentase ketuntasan siswa sebesar 54,84% pada siklus I sebesar 69,23% dan pada siklus II menjadi 96,30%. (2) penggunaan model pembelajaran kooperatif padu padan dapat meningkatkan efektifitas belajar yang awalnya pada pra tindakan siswa kurang berpartisipasi dalam pembelajaran, perlahan siswa memperhatikan guru dalam menjelaskan materi, siswa lebih berani bertanya dan mengemukakan pendapatnya dalam pembelajaran dan diskusi kelompok.

 
Kata Kunci : Model Pembelajaran Kooperatif Padu Padan
Total flavonoids of Chinese herb Rhizoma Drynariae alleviates bone loss in caged laying hens
Authors: Huang Jie , Yu Zhengwang , Tong Xiaofeng , Zhang Lei , Hu Yanping , Zhou Zhongxin
Published: February 2020

Background: Caged layer osteoporosis (CLO) is a common bone metabolic disease and is threatening the modern poultry industry. The objective of this study was to evaluate effects of total flavonoids of Rhizoma Drynariae (TFRD), a Chinese herbal extract, on bone health, egg quality and production performance in caged laying hens. Totals of 144 Lohmann pink-shell laying hens of 32-wk-old were randomly allocated to 4 groups. The control (CON) group was fed a basal diet, the low calcium diet (LCD) group was fed a low calcium diet, and the TFRD1 and TFRD2 groups were fed LCD supplemented with 0.5 and 2.0 g/kg TFRD, respectively. The experiment lasted 9 wks.
Results: Supplying 2.0 g/kg TFRD produced protective effects on calcium deficiency-induced bone loss in caged laying hens, including enhanced femur bone mineral density (P < 0.05), improved bone microarchitecture deterioration, reduced serum levels of alkaline phosphatase and tartrate resistant acid phosphatase activities (both P < 0.05) and osteocalcin content (P < 0.05), down-regulated mRNA expressions of receptor activator of nuclear factor kappa-B ligand (RANKL) (P < 0.01) and up-regulated runt related transcription factor 2 (RUNX2) and osteoprotegerin (OPG) levels (both P < 0.01). Furthermore, compared to LCD group, 2.0 g/kg TFRD treatment had lower malondialdehyd levels (P < 0.01), and higher total antioxidant capacity (P < 0.05) and glutathione peroxidase (P < 0.05) activities, which contributed to the protective effects of bone loss. TFRD supplementation did not affect egg quality while 2.0 g/kg TFRD treatment improved laying rate (P < 0.05) and decreased feed conversion ratio (P < 0.05).
Conclusions: These findings suggested that TFRD has beneficial effects on bone health and production performance in caged laying hens, which can be used for the prevention of CLO.
Interdependence of producers’ adoption decision of agronomic Practices in maize production; evidence from northwest Ethiopia
Authors: Dessie Abebe Birara , Abate Tadie Mirie , Mekie Taye Melese
Published: February 2020

The authors have withdrawn this preprint from Research Square.
Prevalence of Yellow fever virus infection and associated factors among acute febrile patients in Arbaminch districts, Southern Ethiopia
Authors: Eshetu Daniel , Alemayehu Tsegaye , Wube Temesgen bizuayehu
Published: February 2020

Yellow fever is a rapidly emerging arthropod-borne viral infection, which causes considerable illness and death worldwide. However, little is known regarding the epidemiology of yellow fever virus infection in Ethiopia where mosquito-borne diseases like malaria are common. This study aimed to determine the seroprevalence of yellow fever virus infection and its associated factors among febrile illness in Arbaminch districts in Southern Ethiopia. An institution-based cross-sectional study was conducted in a consecutive group of 529 acute febrile patients between May to August 2016. Data on socio-demographic, environmental and clinical signs and symptoms were collected using structured questionnaires. Serum was used to detect anti-yellow fever virus IgG and/or IgM using indirect Immunofluorescent assay (Euro immune Biochip mosaics, Lübeck, Germany). A logistic regression analysis was done using SPSS V-20 (IBM Corp, 2012). P-value < 0.05 was taken as statistically significant. Of the tested 529 serum samples 14.9% and 7.2% were positive for anti-yellow fever IgG and IgM respectively. Among IgG positive patients, males accounted for 15.04% and female 14.85%. Yellow fever exposure was more in the younger age group; participants age less than 20 years (26.80%), followed by those in the age group above 60 years (26.47%). Further, the prevalence of yellow fever exposure among urban residents was 37.14%. Of the assessed risk factors, only constitutional symptoms were significantly associated with the Yellow fever virus (AOR = 0.28, 95% CI 0.30- 0.72.P < 0.011). The laboratory finding of this study shows, the level of exposure to yellow fever among febrile cases is relatively high; however, clinical diagnosis of febrile patients is a common practice in the study area. Therefore, Domestication and routine performance of yellow fever virus differential diagnosis will help to address the phenomenon of the virus.
Resistance profile from Staphylococcus aureus and Pseudomonas aeruginosa Obtained from tracheostomized children
Authors: Almeida Juliana Afonso de , Barros Caroline Espíndola de , Ayres Gustavo Henrique da Silva , Silva Mariana Helena e , Liberal Andressa Santos , Batista Marcos Antonio , Gomes Raylane Pereira , Filho Arlindo Rodrigues Galvão , Silva Carla Afonso da , Wastowski Isabela Jubé , Carneiro Lilian Carla , Avelino Melissa Ameloti Gomes
Published: February 2020

Background The tracheostomized patients exhibit high risks of bacterial infections, because the tracheal tube acts as a gateway to these microorganisms. The objective was to characterize microbiologically the tracheal secretion of tracheostomized children, to evaluate the biofilm formation, and to study the phenotypic and molecular profile of antimicrobial resistance of Staphylococcus aureus and Pseudomonas aeruginosa isolated. Methods The study collected 88 tracheal secretion samples. The material processed by phenotypic tests were performed for bacterial identification. For identification of the biofilm, the Congo red agar test and the plaque microtiter test were used, and the qPCR method was used to resistance verification. Results Were obtained 27 samples of S. aureus and 71 of P. aeruginosa . All S. aureus samples were positive for biofilm formation on Congo red agar test. In antibiogram test, S. aureus showed resistance to seven drugs. Regarding the identification of resistance genes, were amplificated bla Z in 42.8% from S. aureus and mec A in 28.6% of them. Pseudomonas aeruginosa presented resistance to eight drugs. The most frequent chromosomal genes were bla OXA with 66.7% and bla KPC with 58.3%. To plasmidial DNA, was highlighted bla NDM with 58.3% positive. ConclusionThe S. aureus and P. aeruginosa characterization of colonization from lower respiratory tract associated with the use of the device in tracheotomy patients, and the physiology and antimicrobial resistance profile, will help health professionals to choose the most appropriate treatment to be administered in children with tracheotomy, increasing the chances of airway restoration and decannulation.
Cutaneous breast cancer metastases successfully treated using an oxygen flow assisted administration of methotrexate (OFAMTX5%)
Authors: Jouret Gaëlle , Gonne Elodie , Quatresooz Pascale , Reginster Marie-Annick , Collins Patrick , Lebas Eve , Jerusalem Guy , Nikkels Arjen F
Published: February 2020

Introduction: Cutaneous metastases of breast cancer (CMOBC) remain a therapeutic challenge. Recently, oxygen flow assisted topical administration of methotrexate 3% (OFAMTX5%) was proven an efficacious alternative treatment for extramammary Paget’s disease, an in situ mammary adenocarcinoma.
Aim: To evaluate the efficacy and tolerance of OFAMTX5% for the treatment of CMOBC.
Materials and methods: A patient with triple negative breast cancer presented with biopsy proven CMOBC. Two weekly sessions were given for 2 weeks with OFAMTX5% on a site of approximately 40 cm 2 . Skin biopsies were performed before and 2 months after procedure.
Results: Tolerance was excellent with no pain sensations. Two months post procedure the treated area presented a postinflammatory hyperpigmentation. No residual metastases were evidenced on the control skin biopsy.
Discussion: In selected cases of CMOBC OFAMTX5% can represent a non-painfull and efficacious treatment alternative. Larger series should evaluate the place of OFAMTX5% for the treatment of CMOBC.
IKBKE is a critical mediator of TAM-induced breast cancer resistance to BET inhibition
Authors: Qiao Jianghua , Chen Yibing , Mi Yanjun , Jin Huan , Wang Lina , Huang Ting , Li Haolong , Song Yucen , Cao Jun , Wang Qiming , Zou zhengzhi
Published: February 2020

Background: BET inhibitors (BETi) exhibit a strong anti-tumor activity in triple-negative breast cancer (TNBC). However, BETi resistance has been reported in TNBC. The mechanisms of resistance have not been demonstrated. Tumor-associated macrophages (TAMs) are frequently involved in cancer cells resistance to chemotherapy, also associated with poor prognosis in TNBC. However, the role of TAMs in BETi resistance remains unknown. Method: The expression of RNA was evaluated by qRT-PCR. Protein was detected by Western blot, immunofluorescence and Enzyme linked immunosorbent assay (ELISA). Cell viability was detected by Cell Counting Kit-8 (CCK-8). Apoptosis was evaluated by Annexin V-FITC/PI, TUNEL assays and Hoechst 33258 staining. NF-κB activities were detected by luciferase reporter assays. Mice model of breast cancer was established with subcutaneous xenograft tumor. Detailed mechanistic studies were performed by using inhibitors, RNA interference and DNA transfections. Results: Here, we found that BETi JQ1 and I-BET151 exerted anti-tumor effects in TNBC by decreasing IKBKE expression to attenuate NF-κB signaling. BET inhibition was found to downregulate IKBKE levels through BRD2/E2F1 axis. Moreover, we firstly found that TNBC-stimulated TAMs activated NF-κB signaling by upregulating IKBKE expression to enhance breast cancer cells resistance to BETi. The IKBKE levels were also proved to be higher in clinical TNBC tissues than Non-TNBC tissues, suggesting feedback induction of IKBKE expression by TNBC-stimulated TAMs in TNBC. In addition, the induction of IKBKE by TAMs in TNBC cells was identified to be associated with STAT3 signaling, which was activated by TAM-secreted IL-6 and IL-10. Lastly, the combination of inhibitors of BET and STAT3 exerted a synergistic inhibition effects in TAM-cocultured or TAM CM-treated TNBC cells in vitro and in vivo . Conclusion: Altogether, our findings illustrated TNBC-activated macrophages conferred TNBC cells resistance to BETi via IL-6 or IL-10/STAT3/IKBKE/NF-κB axis. Blockade of IKBKE or double inhibition of BET and STAT3 might be a novel strategy for treatment of TNBC.