bluuebunny/crossref_metadata_2025 huggingface dataset:
ПСИХОЛОГІЧНІ ОСОБОЛИВОСТІ ТЬЮТОРА ЯК СКЛАДОВА ПРОФЕСІЙНОЇ КОМПЕТЕНТНОСТІ ВЧИТЕЛІВ ЗАКЛАДІВ СЕРЕДНЬОЇ ОСВІТИ
Authors: Крикуненко Марія , Коляда Наталія
Published: October 2023

Розвиток освіти в Україні вимагає впровадження нових форм і методів роботи з учнями. Підготовка високопрофесійних спеціалістів повинна здійснюватися з урахуванням набутого зарубіжного досвіду з використанням ефективних сучасних інноваційних технологій. Значне поширення у світі концепцій розвивального навчання, особистісно-центрованої освіти, контекстного та модульного навчання, а також ігор актуалізували необхідність перегляду уявлень про навчання, новий статус і роль учителя.
EXPERIMENTAL DEVELOPMENT OF THE METHOD OF SEAMLESS CONNECTION OF THE DURA MATER USING HIGH-FREQUENCY BIPOLAR ELECTRIC WELDING AND SUBSTANTIATION OF ITS GREATER TIGHTNESS, COMPARED TO THE TRADITIONAL METHOD OF CONNECTION USING SUTURE MATERIAL
Authors: Zabolotnyi Dmytro , Kvasha Olena
Published: October 2023

One of the main tasks of surgical treatment of patients with frontal sinus neoplasms with intracranial spread is to seal the subdural space, which is achieved by hermetically connected dura mater. The purpose of this study was to investigate the structure of the tissues of the dura mater and dura mater-fascia junction using bipolar electric welding. The obtained data shows, that electric welding provided a stable advantage in the tensile strength and tightness of the electric welded connection, compared to the connection using suture material. The value of the tensile strength for the connection of the DM with the DM was established - 32.795±0.1 (increase in strength compared to the suture connection by 1.35 times) mm Hg, for the connection of the DM with the aponeurosis of the skull 30, 71±0.37 (1.26 times increase in strength compared to the suture connection), for the connection of DM with the fascia lata was 29.67±0.33 mmHg. (increase in strength compared to a seam connection by 1.22 times). Also the methods of light microscopy and infrared spectroscopy were used. When evaluating the results, no β-structured aggregates were observed in the tissue samples under study. There was minimal traumatic damage to the adjacent dura mater tissue and minimal thermal damage from vaporisation. Pacchioni granulations, venous pial, and cortical vessels of the dura mater were preserved. The study observed complete identity of the wave values of amide A, B, amide I, II spectra; preservation of amide A, B peaks. Preservation and curvature of the N-H arm and O=C-N band were changed within acceptable limits. The findings indicate the absence of β-structured protein aggregates in the junction area, which excludes the possibility of fibrous structures and, as a result, does not contribute to the formation of a meningeal scar. The structure of the collagen protein in the junction area is normal, altered but intact, with preservation of its functions. This indicates the feasibility of using the method of high-frequency bipolar electric welding for surgical closure of defects of the dura mater, as an alternative to closure with suture material
МЕДИКАМЕНТОЗНІ УРАЖЕННЯ ПЕЧІНКИ – У ФОКУСІ НЕСТЕРОЇДНІ ПРОТИЗАПАЛЬНІ ЗАСОБИ
Authors: Коморовський Роман , Гладких Федір
Published: October 2023

Медикаментозне ураження печінки є частим диференціальним діагнозом у пацієнтів з гострим ураженням печінки без явної етіології. Гепатотоксичність частіше виявляють під час постмаркетингових досліджень або навіть набагато пізніше [1–3]. Понад 1200 препаратів зареєстровані як потенційні гепатотоксичні. Медикаментозний гепатит є основною причиною печінкової недостатності, зокрема при передозуванні парацетамолу (близько 50%).
Stylized Facts From Prices at Multi-Channel Retailers in Mexico
Authors:   , Solórzano Diego
Published: October 2023

Using data gathered through web scraping techniques, this paper characterizes product categories' frequency, size and dispersion of price changes in eight retail chains in Mexico, and compare them with price statistics stemming from brick and mortar stores data of the same retailers. Notably, between 2016 and 2019, prices observed in brick and mortar stores (offline) change more frequently than those observed on websites (online). However, given a price change, online prices tend to exhibit larger price changes than their offline counterparts. In 2020, period affected by the pandemic, the above relationship across sales channel holds, while the frequency of price changes increased roughly by the same magnitude in both sales channels and the average size of price adjustments did not change relative to previous years. Results from this paper highlight the importance of recognizing the differences between survey and web scraped data.
UTILITY OF OBSTETRIC NATIONAL EARLY WARNING SYSTEM IN EARLY IDENTIFICATION AND MANAGEMENT OF MATERNAL COMPLICATION IN ANTENATAL WOMEN ADMITTED IN B.R.D. MEDICAL COLLEGE GORAKHPUR
Authors: Ankita Ankita , Vijayalakshmi Vijayalakshmi , Aditya Vani , Sharma Santosh , Bano Khutaija , Tiwari HarishChandra
Published: October 2023

Background: Maternal mortality is still a major challenge for health systems, while severe maternal
complications are the primary causes of maternal death. Our study aimed to determine utility of obstetric
national early warning system (ONEWS) in early identication and management of maternal complication in antenatal
women. This case-control study conducted on 400 women admitted to department of Obs and gynae mor Methods: e than or
equal to 34weeks pregnant after taking informed written consent. In group-A risk scoring of each patient was done as per
ONEWS scoring system whereas in group-B frequency of observation, monitoring and necessary action was taken according to
existing hospital protocol. Patient managed by ONEWS system have longer hospital-stay than controls Results: (p=.0015).
6.50% patients from study group and 14.50% of controls needed critical-care (p=0.091), patients followed with ONEWS had
early detection of trigger parameter which leads to early detection and management which decreases critical-care need. Mean
ICU stay was less for cases than controls. Commonest cause of mortality was hypertensive disorder of pregnancy and
associated complication (1 in case, 3 in control) followed by post-partum hemorrhage with DIC.(41.0%) of cases and (55.0%) of
control s developed CAMO (p<0.001), indicate that ONEWS leads to early detection of trigger parameter which decreases
CAMO. Use of ONEWS leads to homogeneous distribution of monitoring which decreases implementation Conclusion:
variation. ONEWS is simple bedside tool without need of high cost and maintenance equipment and can be implemented by
nurse or junior resident, thus reduces wastage of manpower.
DETERMINANTS OF CAESAREAN SECTION AND ITS OUTCOMES: A CROSSSECTIONAL STUDY
Authors: Taranum Arshiya , Devi Pati Lakshmi , Param Koolath Mangalya , Muntazeem. G Muhammad
Published: October 2023

Caesarean section delivery (CS) is a major life-saving obstetric surgical intervention for mothers and
babies from pregnancy and childbirth related complications. However, the CS deliveries conducted due
to reasons beyond a medical emergency may lead to different type of complications during post-natal period and may lead to
various kinds of gynaecological morbidities. Objective: To study the socio-demographic factors affecting the preference of CS
,the indications and the immediate and delayed complications of CS deliveries. Methods: This hospital-based descriptive,
cross-sectional study was conducted over a period of one year from May 2021 to June 2022 in the Urban health centre of a
Tertairy care Hospital. Data of Patients who delivered by CS was collected, for the socio-demographic prole, its indications
and complications. Results: Previous LSCS was the leading indication for CS (38.9%) followed by fetal distress 79 (22.3%) and
others. Among the immediate complications, difculty in breastfeeding was the commonest in (45.91%),followed by post
operative fever (35.2%). Among the delayed complications, backache was the commonest seen in (60%) followed by Lower
abdominal pain (49.2%). Conclusion: Even though there are some serious and many minor complication associated with CS ,
women who are voluntarily choosing CS deliveries are from private health facilities than in public health facilities,majority
from urban areas with good education status.
WATERWORLD: A HYDRO-MOLECULAR HYPOTHESIS OF NEUROCOMPUTATION
Authors: Sfera Adonis
Published: October 2023

Proteins are the building blocks of life which are encoded in
the genome and regulated by the environment via epigenomic
modulation. These biomolecules possess Transformers-like
abilities to instantly change shape, assemble and
disassemble, birthing compounds with different biological
functions. Proteins also present with origami-like capabilities
of folding along specic lines, engendering functional or
prion-like pathological entities. These properties enable a
multitude of physiological processes in the living world,
ranging from endocrine control and immunity to memory and
self-awareness. Furthermore, biomolecules are endowed with
other equally amazing qualities including, linking to each
other in Lego-like fashion, electronic conductance and
generation of allosteric or vibration "bar codes" which may
enable long term potentiation and memory. In addition,
proteins may facilitate synchronization of neuronal ring
rates among anatomically distant areas of the CNS, a
phenomenon believed necessary for consciousness. In this
article we hypothesize that global molecular networks are
physiologically turned "on" during wakefulness and "off"
during sleep by the extracellular space water, accounting for
the difference in neurocomputation modes during the two
circadian states.
LONG-TERM METABOLIC CONSEQUENCES OF COVID-19: A RETROSPECTIVE COHORT STUDY ON NEW ONSET DIABETES MELLITUS, HYPERTENSION, AND DYSLIPIDEMIA
Authors: Hussain Nazar , Ahmed Arshad , Sharma Sheetal , Badyal Kulbhushan , Majid Majid
Published: October 2023

Background: The COVID-19 pandemic caused by SARS-CoV-2 has raised concerns about its potential
impact beyond acute respiratory symptoms. Emerging evidence suggests an alarming trend of newonset metabolic disorders, including diabetes mellitus, hypertension, and dyslipidemia, following recovery from COVID-19.
Understanding the underlying mechanisms and risk factors is essential for devising preventive strategies and interventions.
Methods: A retrospective cohort study was conducted using electronic health records (EHRs) of adult patients diagnosed with
COVID-19 between January 2020 and December 2021. Patients with pre-existing metabolic disorders were excluded. Data
collected included demographic information, COVID-19 severity, inammatory markers, comorbidities, and medications used
during hospitalization. Results: Among 380 patients, 26.3% developed new-onset diabetes, 39.5% experienced new-onset
hypertension, and 34.2% developed new-onset dyslipidemia post-COVID-19 recovery. Age, COVID-19 severity, inammatory
markers, and pre-existing comorbidities were identied as signicant risk factors associated with new-onset metabolic
disorders. Conclusion: This study emphasizes the importance of understanding the complex relationship between COVID-19
and metabolic health to develop effective preventive and therapeutic strategies. Addressing underlying health conditions and
inammation modulation may hold promise for mitigating long-term health implications post-COVID-19. This research
contributes valuable insights to safeguard the well-being of individuals in the aftermath of the pandemic.
EFFECTIVENESS OF LAUGHTER THERAPY ON LEVEL OF STRESS AMONG ELDERLY PEOPLE RESIDING IN SELECTED OLD AGE HOME”: A QUASI EXPERIMENTAL STUDY.
Authors: Shende Swati , Barbatkar Siddheshwari , Azad Suman
Published: October 2023

Old age is inevitable. Nobody can stop the aging process of the human body. But it is possible to keep the
mind agile and active to a great extent. Stress management is a wide spectrum of techniques and
psychotherapies aimed at controlling a person's level of stress. Laughter provides good exercise to organs and enhances blood
supply. Background: Mental health play's vital role in older age as at any other time of life. The most common emotional
disorder in the elderly population is stress. Laughter therapy is very effective to reduce the stress level of elderly residents of old
age home. Objectives: 1. To assess the Effectiveness of Laughter therapy on level of stress among elderly people residing in
selected old age home. 2. To assess the pre-test level of stress among elderly people residing in selected old age home. 3. To
assess the post-test level of stress among elderly people residing in selected old age home. 4. To evaluate the effectiveness of
laughter therapy on level of stress among elderly people residing in selected old age home. 5. To associate the level of stress
with selected demographical variables. Methodology: A quasi experimental one group pre-test post -test design used for the
study.it was conducted over 60 elderly people by using non probability convenient sampling technique. Result: Assessment
was done by semi structure questionnaire on demographic variable and standardized perceived stress scale on level of stress,
analysis reveals that, comparison of pretest and post-test stress scores of elderly people. Mean, standard deviation and mean
difference values are compared and student's paired 't' test is applied at 5% level of signicance. The tabulated value for n=60-
1 i.e., 59 degrees of freedom was 2.00. The calculated 't' value i.e., 8.03 are much higher than the tabulated value at 5% level of
signicance for overall stress score of elderly people which is statistically acceptable level of signicance. Hence it is
statistically interpreted that the Laughter Therapy on stress score among elderly people was effective. also reveals that there is
association post-test stress score with age (in years), gender and duration of stay in old age home. Conclusion: It is statistically
interpreted that, laughter therapy is effective on level of stress among elderly people residing in selected old age home.
COST-BENEFIT ANALYSIS OF USING BLOCKCHAIN TO REFINE THE PROCESS OF INTERNATIONAL TRADE
Authors: Dongmei Li
Published: October 2023

In September 2016, a new nancial technology company under Barclays completed the world's rst
letter of credit trade nancing transaction using blockchain technology. This new transaction method can
shorten the trade process to as little as 4 hours from 7 to 10 days originally. This transaction is regarded as a simpler, safer, and
faster way of future international trade transactions. This research conducted questionnaire interviews with professionals in
charge of international trade business in domestic banks. The expected values provided by these respondents with professional
knowledge and experience were used as samples. After the data were aggregated, t-value verication was performed and the
cost was calculated. The benets method analyzes the efciency and benets it can bring, and it is hoped that the empirical
results of this research can provide useful references for banks or enterprises.
SJÖGREN'S SYNDROME: A RARE CASE REPORT
Authors: shil Rahul
Published: October 2023

Background: Sjögren's syndrome (SS) is a form of autoimmune exocrinopathy that affects the lacrimal
and salivary glands. This causes the glands to gradually degrade, resulting in the disease's two
signature symptoms, dry eyes and dry mouth. Rarely, a few cases of Sjögren's syndrome (SS) have been reported from the
Indian subcontinent. As a result, this condition is not frequently encountered in our region. Even though the disease is
uncommon, early detection is crucial to preventing future consequences. The aim of this paper is to emphasize the treatment
protocol, diagnostic measures, and management of Sjögren's syndrome. Case Presentation: A 40-year-old female was
brought to St. John's Medical College Hospital with the complaint of hypothyroidism for 2 months, and she was taken T.
thyronorm 100 mcg OD. Currently presented with fever, chills, and rigors since 2 months, at around 4-5 pm, then developed a
high-grade fever, which was resolved on T. Dolo, followed by profuse sweating, asymptomatic between fever spikes. Previously
presented with generalized mayalgia and cough since 1 month with moderate whitish expectoration and no diurnal or postural
variation, which was resolved 1 week ago. The patient also complained about a weight loss of 5 kg over 2 months and bilateral
calf pain after climbing stairs. Further examination revealed that anti-SSA and RO52 antibodies were positive, and the occular
SICCA with polyarthralgia was also present, which supported the diagnosis of Sjögren's syndrome. The prevalence Outcome:
of Sjögren's syndrome is rare in the hospital, even in tertiary care rheumatology clinics. Therefore, more research is needed to
have a better understanding of preventive and curative approaches regarding Sjögren's syndrome
SPINAL CORD DISEASES IN AYURVEDA – A REVIEW
Authors: Begum Masuma , Baishya Anup , Sarma Tikendrajit
Published: October 2023

Spinal cord diseases are major health issues faced from time to time. Due to the modernization of our
lifestyle, now-a-days spinal cord diseases especially cervical and lumbar disc diseases are increasing
day by day. As the spine controls body's vital functions, it is absolutely necessary to keep spine healthy. In Ayurveda there is no
clear cut description about spinal cord diseases but there are some similar descriptions available in context of Vatavyadhi. It is
one of the most prevailing disease now-a-days. Every one or two person in a family suffers from different types of pain related
disorder mainly musculoskeletal or neurological. The three important causes for spinal cord disease are Dhatukshaya,
Margavaran and Abhighat. The aim of this study is to analyze the different spinal cord diseases mentioned in ayurveda.
ELLIS VAN CREVELD SYNDROME – A RARE CASE REPORT IN A NEONATE
Authors: Renjana S , Mehta Sharad
Published: October 2023

Background : Ellis-van Creveld (EVC) syndrome is a genetic disorder with autosomal recessive transmission with
mutation in EVC and EVC2 gene .It clinically presents with polydactyly, short stature, fine sparse hair, hypoplastic
fingernails, natal teeth, enamel hypoplasia , hypodontia, and malocclusion. Heart defects, especially abnormalities of
atrial septation, have been found in about 60% of cases. In this article, we present a rare case of E Case Presentation: llis
Van Creveld syndrome in a 4 day old male neonate with suckling difficulty, polydactyly and uvular shift . It Conclusion:
is important to diagnose such syndromes early in life so that they can be provided with symptomatic care and support as
well as appropriate surgeries when required. Here, we present a case report of a 4 day old male neon Summary ate who
was brought by his relatives with difficulty in sucking milk . On examination, he had polydactyly in both hands and left
leg . On oral examination, he had labiogingival frenum hypertrophy and uvular shift to right side . USG brain showed
grossly dilated lateral ventricle. He was advised to be on regular follow up for monitoring the development of any
skeletal abnormalities and for oral surgeries.
A DENTIST'S GUIDE FOR GETTING EQUIPPED FOR MEDICAL EMERGENCIES
Authors: Kaur Abhiroop , Bhagat Tamanna , Deswal Supriya
Published: October 2023

A medical emergency is an unannounced threat to a person's life that needs to be dealt with a quick response. A medical
emergency can occur at any time and place, even in a dental clinic. Even though the possibility of a medical emergency
in a dental setting is unlikely, it is not insignificant and cannot be ignored because it can be life-threatening emergency
or even prove fatal. Most of the emergencies can be handled with basic life support, however, some others may also
require specialized pharmacological therapy. Aim of this paper is to review all the medical emergencies that can be
encountered in dental settings, how to deal with them and basic equipment and medications which should be available
in a dental clinic. This paper also highlights the significance of medical history and how we can prevent them to occur.
LIMBERG FLAP FOR PILONIDAL SINUS IN CHILDREN- OUR EXPERIENCE
Authors: Rajan Madhumittha , Sundaram Jegadeesh , Agarwal Prakash
Published: October 2023

Aim Pilonidal sinus is benign yet a condition with significant morbidity and a high chance of recurrence even after
surgical intervention. Out of the multiple procedures described, the Limberg flap provides aesthetic outcomes with less
chance of recurrence. Though this is a well-known procedure in adults, here we describe our institutional experience of
the Limberg flap in the paediatric age group and its outcome. Materials And Methods We reviewed all pilonidal sinus
cases operated in our institute from August 2017 to December 2022. The age, gender, presenting complaints, duration of
surgery, operative time, complications, and recurrence rates were recorded. All patients were followed up at 3, 6, and 9-
month intervals after surgery. ResultsA total of 32 patients were operated during this period. All patients underwent the
Limberg flap technique. Out of 32 patients, 20 were boys and 12 were girls. All the patients were overweight and the
average BMI was 27.8. The common presenting complaints were single sinus without discharge, pain, and multiple
sinuses with serous or pus discharge. The duration of hospital stay ranged from 7 days to 15 days. 5 patients had postoperative complications like seroma and superficial wound infection. At the end of 9 months, one patient had a
recurrence. ConclusionWe found that the Limberg flap technique for pilonidal sinus provides good cosmetic outcomes
with low recurrence rates.
IRON DEFICIENCY ANAEMIA: GLOBAL HEALTH CONCERN
Authors: Thorat Sandhya
Published: October 2023

Introduction: Deficiency of iron is common cause of anaemia that results in iron deficiency anaemia. Low birth weight
premature babies, entirely breastfed infants, children, adolescents, pregnant and lactating women, menopausal women,
elderly people are at risk of development of iron deficiency anaemia. To understand iron deficiency Objective:
anaemia scientifically with special emphasis on “self-care” for preventing and controlling iron deficiency anaemia.
Methodology: Textbooks, WHO global database, PUBMED database, scientific research papers published in journals
are studied for basic understanding of iron deficiency anaemia and role of self-care in iron deficiency anaemia. Results
and Discussion: The study revealed dietary deficiency of iron is an important cause of iron deficiency anaemia.
Conclusion: Health care professionals should be aware of early detection of iron deficiency and prevention of iron
deficiency anaemia through health education on “self-care “
PAIN MANAGEMENT IN PEDIATRIC PATIENTS WITH CANCER
Authors: Saavedra José Francisco Echeverría , Gaibor Diana Carolina Lombeida , Conza Juan Carlos González , Ayala Katherine Paola Pedraza
Published: October 2023

This review explores pain management in pediatric cancer patients, emphasizing morphine usage. Balancing the
unique challenges of this population, the study discusses tailored approaches, including dose titration, administration
routes, monitoring, and addressing adverse effects. Morphine's effectiveness in alleviating moderate to severe pain is
acknowledged, but careful consideration of dosing, adverse events, and the risk of tolerance and withdrawal is
highlighted.A multidisciplinary approach involving oncologists,pain specialists,and palliative care teams is advocated.
By optimizing morphine use while addressing potential complexities, this review contributes to the holistic pain
management of pediatric cancer patients,enhancing their quality of life.
El rezago de la productividad industrial en Venezuela en perspectiva mundial. Renta petrolera y la deuda externa como mecanismos de compensación.
Authors: Delgado Gonzalez Pedro Emilio
Published: October 2023

El presente trabajo argumenta que para comprender las condiciones objetivas de valorización del capital en Venezuela, hay que considerar los cambios tecnológicos ocurridos a escala mundial, asociados a la informatización de los procesos productivos que lograron elevar la productividad de los capitales que producen para el mercado mundial, mientras que en Venezuela el capital se ha acumulado produciendo a pequeña escala para el mercado nacional, siendo la apropiación de renta petrolera el principal mecanismo de compensación de sus elevados costos. La sobrevaluación cambiaria es el principal mecanismo de apropiación. Asimismo, la insuficiencia de la renta obliga a buscar en la deuda externa un flujo de riqueza que permita sostener la economía nacional.
Parcerias Público-Privadas na Administração Penitenciária Brasileira: um comparativo entre o presídio público e o privado
Authors: Aguire Tatiana Sisti , Santos Iracildo Silva
Published: October 2023

O estudo trata das parcerias público-privadas na administração penitenciária do Brasil apresentando panorama comparativo entre os presídios públicos e privados. O objetivo de foi de analisar as Parcerias Público-Privadas na Administração Penitenciária Brasileira, fazendo um comparativo entre os presídios públicos e os privados, avaliando se a Parceria Público-Privada é mais eficiente em relação a Administração Pública. O problema da pesquisa se pautou em descobrir como as parcerias público-privadas podem tornar as penitenciárias mais eficientes em relação a Administração Pública? A metodologia utilizada foi realizada por meio de método exploratório e descritivo, com a técnica da pesquisa bibliográfica em diversas fontes de tratam do tema e análise de dados do Depen – Departamento Penitenciário Nacional. A partir do diálogo com os autores e os dados apresentados foi possível constatar que a parceria público-privada é mais eficiente do que a Administração Pública, em especial pela política de investimentos que possibilita redução de custos operacionais, qualidade nos serviços prestados, maior número de vagas oferecidas e maior número de pessoas estudando, aspectos fundamentais para a ressocialização e reinserção dos presos em sociedade.
A kecskeméti főtér fejlődéstörténete és zöldinfrastruktúra szerepének változása
Authors: Erdélyi Regina , Sallay Ágnes
Published: October 2023

Kecskemét urbanizációs folyamatában a főtér mindig is kiemelt szerepet játszott, a téren történő minden város-építészeti beavatkozás hosszútávon is érezteti hatását. A város közösségi élete javarészt itt zajlik, melyhez a történelem során kialakult épület- és téregyüttes mutatós és méltó keretet ad. Szabadtér-rendszerének és térfalainak alakulása mindig társadalmi és gazdasági szinergiák hatására történt, és igazolható, hogy Kecskemét történelmi központjában a társadalom fejlődésével együtt járóváltozások az építészeti és tájépítészeti térformálásban is megjelentek. Jellemző, hogy térszerkezeti és térhasználatimódosulások maguk után vonták a települési zöldinfrastruktúra egyes elemcsoportjainak fokozatos megjelenését a főtéri téregyüttesben.
From Glands to Nerves: Hypothyroidism’s Underexplored Influence on Neurological Well Being-A Narrative Review
Authors: R Nithya , P Abi Monika A , Abirami S , A Aarthi
Published: October 2023

Hypothyroidism is a clinical health condition in which the thyroid gland secretes insufficient levels of the thyroid hormones T3 and T4, resulting in high thyroid stimulating hormone (TSH) readings. The thyroid gland plays a key role in the development of the central nervous system. These hormones are essential for brain development and function. It has been found that thyroid disorders are among the most common diseases in worldwide. Thyroid disorders are one of the primary causes of cognitive decline, including Alzheimer's disease (AD). In this review, we had discussed about the various neurological complications that develops due to hypothyroidism.
Open Trauma of the Abdomen by Weapons at the Reference Health Center of Commune I of Bamako
Authors: I Diarra, , S Dembélé, K. , M Drame, B. , M Sanogo, , Y Sylla, , C Tounkara, , S Kassogue , M Koné, , B Keita, , S Coulibaly, , B,T Dembélé , L Kanté , A Togo,
Published: October 2023

Purpose: To analyze the outcomes of the management of open trauma to the abdomen by weapons. Methodology: This was a prospective, descriptive study from February 2019 to January 2020. Results: We performed 418 surgeries with 7.65% (32 cases) of open trauma to the abdomen by weapons. The average age was 31.38 years with extremes of 7 to 54 years. The male sex was the most represented 90% or a ratio of 9. The majority of our patients were injured overnight at home or in nightclubs. The assault was criminal with knives in the majority of cases. Abdominal pain and evisceration were the main reasons for consultation. Physical examination and X-ray of the unprepared abdomen (ASP) made the diagnosis. Laparotomy was performed in all our patients with simple consequences. Conclusion: Since the advent of the socio-political crisis in Mali, the proliferation of weapons has encouraged criminal attacks. Their management is complex often multidisciplinary is still controversial between laparotomy from the outset and non-operative treatment.
Pyoderma Gangrenosum: A Promising Therapeutic Protocol
Authors: Bakhil Ayoub , Koualla Sara , Ribag Yasmina , M’FA Keith Sandy , hafidi Nawfal EL , Benbachir Adam , Khalfi, Lahcen , Hamama Jalal , khatib Karim EL
Published: October 2023

Pyoderma gangrenosum (PG) is a medical disease characterized by the appearance of a rapidly expanding loss of skin substance in the absence of any infection and aggravated by any form of trauma. The management is difficult and requires the association of a medical treatment and a covering gesture if necessary. Through a clinical observation we will demonstrate the contribution of a therapeutic protocol associating the injection of platelet rich plasma associated with hyaluronic acid with a treatment by negative pressure in the acceleration of the cicatrization of a loss of substance related to a recurrent PG.
Staff Retention and Organizational Performance in Kasese District in Western Uganda
Authors: Deusdedit Byabashaija , Enos Rwasheema , Habert Baluku
Published: October 2023

The pragmatic study evaluated the association between Staff Retention and Organizational performance in Kasese District in Western Uganda. The inquiry study utilized a cross sectional survey research design with quantitative and qualitative mockups. A sample of 148 participants were carefully chosen from 240 individuals using a table developed by Morgan & Kreijcie (1970). Information was assembled by means of questionnaires and interview schedules. Data was appraised using frequencies, percentages, Pearson linear correlation coefficient (PLCC) for quantitative measurements and thematic analysis was engaged for organizing qualitative proof. The study verdicts came up with a significant relationship between Staff retention and Organizational Performance in Kasese District in Western Uganda. The project team concluded that Staff Retention is vital for increasing the productivity of an organization especially in local governments because it conventions with issues to do with stability of tenure of office. If the employees are well retained in an organization, they can be a source of motivation for socio-economic development of local governments at large. From the research project results, the academics recommended that Staff Retention in Kasese district sub-national government in Uganda should continuously put in place better conditions of work such as descent accommodation, free medical care, payment of overtime allowances and giving scholarships for those who want go for further studies. This can be done through putting in place operational committees to make sure that government policies on staff retention are well cherished and implemented. The government of Uganda should increase on the budget meant to facilitate staff retention function in Human Resource Department so that a big number of local government employees can be retained for effective service delivery in Kasese District local government.
Functional & Clinical Outcomes of Posterior Decompression & Transforaminal Lumbar Interbody Fusion (TLIF) Using Cage and Bone Graft Combined with Stabilization in Lumbar Spondylolisthesis
Authors: Khan Md. Sahidur Rahman , Harun Muhammad Eusuf , Rayhan Md. Ferdous , Naher kamrun , Hasan S M Zubaer , Rahaman Md. Syedur , Khan Md. Tanvir Ahasan Juglol
Published: October 2023

Introduction: Posterior decompression and transforaminal lumbar interbody fusion (TLIF) using cage and bone graft is a surgical technique for treating lumbar spondylolisthesis. This procedure aims to relieve spinal pressure and stabilize the affected vertebral segments. Aim of the study: The aim of this study was to assess the clinical and functional outcomes of posterior decompression & transforaminal lumbar interbody fusion (TLIF) using cage and bone graft combined with stabilization in lumbar spondylolisthesis. Methods: This prospective observational study was carried out at NITOR, Dhaka, Bangladesh, during the period from January 2020 to December 2021. Total 15 patients with degenerative lumbar spondylolisthesis were included in this study. Result: The study assessed 15 patients undergoing surgery for spondylolisthesis, primarily aged 40-49, with a mean age of 46.4 years. Gender distribution was 40% male, 60% female. Pre-operative spondylolisthesis was mostly at L4/L5 (60%) and L5/S1 (40%). Post-op data showed significant reductions in slip angle and VAS scores for back and leg pain (all P<0.05). Foraminal and disc space height increased. Fusion rate was 86.66% per Hackenberg criteria. Motor deficit improved from 33.3% to 6.7% post-op. According to Macnab criteria, 73% had excellent functional outcomes and 26.66% experienced minor complications; no major complications were recorded. Conclusion: As observed from the result of this study, degenerative lumber spondylolisthesis can be treated with posterior decompression and transforaminal lumbar interbody fusion by using cage and bone graft with spinal stabilization. This method enhances neurological recovery, reduces pain and makes the patients able to return to work comfortably.
Association of Melasma with Thyroid Disorders
Authors: Tekou Ayman , Labbene Imen
Published: October 2023

Melasma, a common hyperpigmentation disorder, has been a subject of increasing interest due to its potential association with thyroid disorders. This systematic review and meta-analysis aimed to assess the relationship between melasma and thyroid function indicators, including thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), and thyroid antibodies, particularly anti-thyroid peroxidase (anti-TPO) and antithyroglobulin antibody. A comprehensive search across multiple databases identified 39 relevant studies for analysis. The systematic review and meta-analysis were ultimately conducted based on the data extracted from these 39 selected studies. The meta-analysis revealed significant differences in thyroid function indicators between individuals with melasma and control groups. Melasma patients exhibited higher TSH levels (SMD = 0.33, 95% CI: 0.18, 0.47) and lower T4 levels (SMD = -1.50, 95% CI: -2.96, -0.04). However, no significant difference in T3 levels was observed (SMD = -0.01, 95% CI: -0.20, 0.19). Notably, the presence of anti-TPO antibodies was significantly associated with melasma (Fisher = 26.80, P = 0.020). Gender-specific analyses revealed more pronounced thyroid function differences among women with melasma, suggesting potential hormonal influences. Melasma predominantly affects women and often exhibits exacerbations during pregnancy, indicating a complex interplay between sex hormones and thyroid function in pigmentation regulation. These findings have clinical implications for dermatologists and endocrinologists. Dermatologists should consider thyroid evaluation in melasma patients, especially in cases with treatment resistance. For endocrinologists, melasma could serve as a cutaneous marker for underlying thyroid dysfunction, particularly in women. Further research is needed to elucidate the mechanisms underlying this association and its temporal aspects. Longitudinal studies could provide insights into whether thyroid ........
Outcomes of Conservative Treatment of Uncomplicated Acute Appendicitis in Children
Authors: Rashid Mohammad Syfur , Hossain Mitali , Morshed G. M. , Islam K. M. Shaiful , Islam Md. Majedul , Tablu Abdul Hanif
Published: October 2023

Background: Pediatric healthcare is evolving, with acute appendicitis being a common issue. Traditionally, appendectomy has been the standard treatment. However, recent literature suggests that conservative antibiotic treatment could be a viable option, particularly for uncomplicated cases in children. Aim of the study: The aim of the study was to evaluate the outcomes of conservative treatment for uncomplicated acute appendicitis in children. Methods: From July 2017 to March 2019, a prospective observational study was conducted at Dhaka Medical College Hospital, Bangladesh, involving 62 children with uncomplicated acute appendicitis. They received conservative treatment, including supportive care, for five days. Patients who responded positively within 24 hours continued for at least five days before discharge and underwent a 6-month follow-up. Results: The study encompassed 62 patients, with a mean age of 8.95 years, and a slight male predominance (61.3% male, 38.7% female). Clinical findings revealed a notable decrease in pain intensity (9.42 to 0.77), temperature (101.02º to 98.90º), and inflammatory markers (CRP: 28.13 ± 11.56 mg/L to 9.78 ± 7.50 mg/L) from admission to day 5. The mean duration of hospital stay was 5.26 ± 0.63 days. Remarkably, 95.1% of patients successfully recovered with conservative treatment, while 4.9% required surgery as part of their treatment course. Conclusion: This study found some potential benefits of conservative treatment for uncomplicated acute appendicitis in children. Significant improvements in clinical parameters and a high success rate emphasize its potential as a viable alternative to surgery in select cases, warranting further exploration in pediatric healthcare practices.
Evaluation of Visual Inspection of Cervix with Acetic Acid in Detecting Precancerous Lesions
Authors: Begum Asma , Rahman Mohammad Moshiour , Akhter Sumyia , Afroz Sharmin , Begum Amena
Published: October 2023

Background: Cervical cancer is a major public health problem in Bangladesh without widespread organized cervical screening programs. The acetic acid visual inspection of the cervix (VIA) is an efficient, low-cost screening test that can be paired with easy treatment procedures for early cervical lesions provided by skilled health workers. To evaluate the effect of any prevention program on cervical cancer incidence and mortality rates, women aged 25 to 50 must be adequately covered. VIA is a cost-saving method of screening, according to mathematical modeling of the expenses of various screening procedures in Bangladesh. Methods: Total 100 eligible woman who randomly came to the VIA centre of BSMMU were examined by VIA detection of well defined, opaque, acetowhite lesions close to the squamocolumner junction or in transitional zone or dense acetowhitening of ulcero proliferative growth on the cervix constitute a positive VIA Those who had abnormal results in screening test and those who had clinically suspicions lesion were sent for colposcopic evaluation and directed biopsy were taken from colposcopically suspected area. The final diagnosis was based on histology. Results: Healthy cervix was in 11 cases (11%) suspected inflammation was 4 cases (4%), CIN-I was 58 cases (58%), CIN-II was in 14 cases (14%), CNN-III was in 10 cases (10%), and invasive carcinoma was in 3 case (3%). Out of 100 patients biopsied, cervical intraepithelial neoplasia found among 81% cases of which CIN was in 52.5%, CIN II was in 17% and CIN III was in 8.5%. Invasive carcinoma found in 3% and inflammation was in 4% cases. Conclusion: VIA was as effective as colposcopy at detecting various grades of intraepithelial cervix lesions. Here, VIA was suitable for the diagnosis, follow-up care, and epidemiological research of cervical cancer, as well as for the detection of precancerous lesions in low resource settings.
Complete Removable Prosthesis Stabilized on Implants: Interest and Use of the Locator® Attachment
Authors: Wafa Mami , Wadii Bembli , Nihel Charfi , Rim Bibi , Nadia Frih
Published: October 2023

The complete removable denture retained by implants is a widely used therapeutic option, recognized for its functional and psychological esthetic rendering. Currently, the practitioner has an arsenal of retention systems at his disposal (axial attachments, anchor bars...) and since 2000, the Locator® attachment has been added to the large number of axial attachments. Thus, this article proposes to describe it and to expose, through two clinical cases, the process of its placement.
Resection of Multirooted Teeth: A Still Valid Treatment of Periodontal Disease - with Representative Cases
Authors: Azouni Khalid G.
Published: October 2023

Root resection is an old dental treatment modality that is still currently used in the management of periodontal disease affecting multirooted teeth with furcations. This article explores this dental treatment modality, its history, and its use. This concept of dental treatment is illustrated by some representative cases done in a periodontal practice within primary healthcare settings with some learned lessons explained.
An Improved XShanker Distribution with Applications to Rainfall and Vinyl Chloride Data
Authors: Etaga Harrison O. , Nwankwo Mmesoma P. , Oramulu Dorathy O. , Obulezi Okechukwu J.
Published: October 2023

This article is an improvement on the XShanker distribution having a single parameter which is the scale parameter and also in the class of Lindley distributions. It is named Double XShanker following the approach that generated it. The distributional properties which include the non-central moment with the associated statistics, the moment generating function, characteristic function, mean residual life function, stress-strength reliability function, Bonferroni and Lorenz curve functions, odd function, stochastic ordering, distribution of order statistics, and Reny entropy. The parameter was estimated using the method of maximum likelihood. Some visualizations based on theoretical values were presented. Some statistics were computed from theoretical values with convergence behavior recorded. A simulation study was conducted with 1000 samples of different sizes and the behavior observed is that as sample size increases the estimates decrease indicating precision. Data on rainfall and Vinyl chloride were used to validate the usefulness of the suggested distribution.
Incidental Finding of Mounier-Kuhn Syndrome
Authors: J Hamdane. , J Ait si Abdessadeq.
Published: October 2023

Tracheobronchomegaly (TBM) or Mounier - Kuhn syndrome is a rare disorder of uncertain etiology characterized by marked dilatation of the trachea and bronchi and recurrent lower respiratory tract infection. We report the case of a 56-year-old male presenting with a chronic cough.
The Hidden Economic Consequences of Migraine to the UK Government: Burden-of-Disease Analysis Using a Fiscal Framework
Authors: Martins Rui , Large Samuel , Russell Rachel , Surmay Gary , Connolly Mark
Published: October 2023

Background: Migraine is a highly prevalent and incapacitating neurological disorder associated with the highest global disability burden in people aged 15 to 49 years. Europe has the fourth-highest prevalence of migraine, after North America, South America, and Central America, and above Asia and Africa. Migraine leads to relatively modest direct healthcare expenditure but has substantial indirect costs due to reduced productivity. Methods: The economic burden of migraine was estimated in comparison with the general population of the United Kingdom (UK) using an analytical fiscal modeling framework applying the government cost perspective. Published measures of migraine’s impact on labor participation were applied to rates of economic activity/inactivity of the general population. The model estimates lifetime changes to earnings from employment, direct and indirect taxes paid, and financial support requirements over the life course. Incremental differences between those affected and unaffected by migraine are reported as net fiscal consequences to public accounts. Fiscal costs are reported as the discounted average per capita over a 20-year time horizon and for the entire annual UK cohort with prevalent migraine. Results: People affected by migraine are more likely to be absent from work, unemployed, and disabled, and to retire early. A 44-year-old individual affected by migraine was associated with £19 823 in excess fiscal costs to the UK government, £1379 per year living with the condition, compared with someone not affected by the disease. Annually, migraine was estimated to represent £12.20 billion to the public economy, approximately £130.63 per migraine episode. The model predicted annual productivity losses in the health and social care workforce to be £2.05 billion and total annual productivity losses to be over £5.81 billion. Conclusions: This fiscal analysis monetizes the occupational consequences of migraine to the UK government, both in terms of lost tax revenue and transfer payments. The findings are substantial and useful to characterize disease severity and to inform the body of evidence considered by decision makers appraising the cost-effectiveness of health technologies.
A rare case of high risk multisystem Langerhans Cell Histiocytosis in infant
Authors: Sulaiman Seerwan Hamadameen , Demir Halit
Published: October 2023

Objective: Langerhans cell histiocytosis (LCH) stands as the most common histiocytic disorder. It is categorized into single-system single site, single-system multi-site, and multisystem types, with or without involvement of risk organs. Clinical presentation exhibits considerable variability, contingent upon the affected organ systems. Given its rarity, diverse locations, and varying severity, there are currently no established treatment guidelines for LCH.
Case Presentation: We documented the case of a 5-month-old male diagnosed with Langerhans cell histiocytosis (LCH), presenting with high-risk multisystem organ involvement and concurrent unifocal bone involvement. Bone marrow aspiration revealed infiltration by multinucleated giant cells within the marrow. Skin biopsy demonstrated Langerhans cell proliferation with epidermotrophism and the characteristic reniform nucleus resembling a coffee bean. The patient was treated following the histiocytosis protocol, which included daily oral prednisone and 6-mercaptopurine, in addition to weekly intravenous vinblastine and methotrexate administered every two weeks. Unfortunately, the patient displayed limited response during the initial phase of treatment and, tragically, passed away during the eighth week of therapy.
Conclusion: Langerhans cell histiocytosis (LCH) is a rare disease characterized by variable disease presentations and is associated with significant morbidity and mortality. Timely recognition of clinical manifestations and risk factors, coupled with appropriate treatment, is crucial to reduce mortality and long-term complications associated with the condition.