bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of COX-2 for Successful Embryo Implantation Process: A Mini-review
Authors: Puspita Ratna Dewi , Rizal Dicky Moch , Syarif Rul Afiyah , Sari Ika Puspita
Published: February 2023

The endometrium undergoes a dynamic proliferation of cells and vascular tissue under the influence of ovarian steroid hormones. Implantation is an essential process in the development of pregnancy, where there is close contact between embryo and uterus, including supposition, adhesion, and invasion. The changes occur in the human endometrium, including endometrial secretion changes, blood vessels, and immune response, leading to the uterine receptivity period. Cyclooxygenase (COX) is an enzyme that plays a role in the metabolic conversion of arachidonic acid to prostaglandins (PG). It is known that Cyclooxygenase-2 (COX-2) plays a key role in the endometrium. COX-2 is essential for blastocyst implantation and decidualization. The deficiency of COX-2, but not COX-1, results in multiple female reproductive failures (including implantation defects). We reviewed the literature on COX-2 and embryonal implantation in the endometrium and its potential mechanisms that lead to physiological implantation. This review aims to identify the essential roles of COX-2 in the successful implantation process, especially in decidualization, implantation, and embryo growth. The regulation of COX-2 expression in endometrial cells is controlled by ovarian steroid hormones (progesterone and estrogen) through the ENaC pathway to regulate the phosphorylation CREB transcription factor. The presentation of COX-2 varies throughout the stage of embryo development.
Application of the theory of planned behavior (TPB) to the analysis of the factors affecting the intention to accept circular economy models of Vietnam consumers
Authors: Nguyễn Hà My
Published: February 2023

The study applies the theory of planned behavior (TPB) in the analysis to understand the acceptance of Vietnamese consumers for circular economy models. The research team conducted a survey of consumers in the Hanoi area to represent Vietnamese consumers. With 327 valid and standard questionnaires obtained, it is found that the scales are meaningful and the independent factors have a positive impact on the dependent variable. Thus, it can be seen that the consumer's intention can be affected by the factors Attitude, Subjective Norm, Perceived behavioral control. From there, businesses can adjust their activities when our country follows the trend of the circular economy
Commatarcha galicicae Tokár & Srnka, sp. nov., and a genus new for Europe (Lepidoptera, Carposinidae)
Authors: Tokár Zdenko , Srnka Ľubomír , Mutanen Marko
Published: February 2023

Commatarcha galicicae Tokár & Srnka, sp. nov. is described from specimens taken in two south-eastern European localities, the Galičica Mountain in North Macedonia, and Dubova in Banat, Romania. The new species belongs to the genus Commatarcha Meyrick, 1935, which is new for the European Lepidoptera fauna. It resembles some Asian species from this genus and also the American species Bondia comonana (Kearfott, 1907) in external characters. In the genitalia of both sexes, it is similar to C. oresbia Diakonoff, 1989 but differs markedly in the colour and pattern of the forewing. The immature stages of the new species are unknown. Colour photographs of the adults and of the habitat are included with illustrations of the female and male genitalia.
A taxonomic revision of Keraunea, including three new species and its phylogenetic realignment with Ehretiaceae (Boraginales)
Authors: Moonlight Peter W. , Cardoso Domingos Benício Oliveira Silva
Published: February 2023

Keraunea is an enigmatic genus of lianescent shrubs endemic to Brazil and found within the Caatinga and Mata Atlântica phytogeographic regions. When first published, Keraunea was included in the Convolvulaceae and there has been considerable recent disagreement about its true family placement on the Angiosperm tree of life. Based on further assessment of morphology and a new comprehensively-sampled combined phylogenetic analysis of nuclear and plastid genes from recently published DNA sequence data, we settle the position of the genus within the Ehretiaceae as sister to the Australian genus Halgania Gaudich. and provide an expanded family description. We recognize five species within Keraunea, three of them newly described here: K. brasiliensis Cheek & Simão-Bianchini, K. bullata Moonlight & D.B.O.S.Cardoso, sp. nov., K. capixaba Lombardi, K. confusa Moonlight & D.B.O.S.Cardoso, sp. nov. and K. velutina Moonlight & D.B.O.S.Cardoso, sp. nov. We also provide a full taxonomic revision of the genus, including a key, descriptions, map of geographical distribution and provisional IUCN threat assessments for all species.
Se rêver mère, rêver son enfant dans le contexte incertain de la précarité
Authors: Riazuelo Hélène , Adda Mélanie , Chaudoye Guillemine
Published: February 2023

Au cours d’une recherche clinique, la parole est donnée à des parents en situation de précarité. Nous proposons deux entretiens enregistrés, l’un pendant la grossesse, l’autre après l’accouchement. Par la mise en récit des expériences passées et actuelles, la construction d’une pensée dans l’après-coup devient possible. Tracer ou retracer une histoire, favorise la relance d’une certaine réflexivité. Dans le discours des participants, les représentations, les rêveries autour du berceau sont multiples. Malgré l’émergence d’éléments traumatiques, d’incertitudes liées à la précarité, les représentations maternelles concernant l’enfant ne sont ni abrasées ni envahies par la situation de précarité.
Valorisons les langues maternelles
Authors: Tessarech Sarah
Published: February 2023

Une orthophoniste évoque les a priori tenaces au sujet du bilinguisme et les répercussions dramatiques que cela peut entraîner sur tous les plans du développement de l’enfant. Études scientifiques à l’appui, elle argumente pour un positionnement professionnel soutenant l’usage des langues maternelles. L’auteure aborde également les distinctions entre pseudo-troubles du langage et particularité du développement du langage chez l’enfant bilingue en proposant l’usage de ressources adaptées.
Posterior Capsulotomy Size Affects the Formation of Significant Visual Axis Opacification in Congenital and Developmental Cataract
Authors: Yucel Ozlem Eski , Gul Adem
Published: February 2023

Purpose:

To assess the relationship between posterior capsulotomy size and significant visual axis opacification (VAO) in congenital and developmental cataract.

Methods:

The charts of children aged 7 years and younger who underwent cataract surgery including primary posterior capsulotomy (PPC) and limited anterior vitrectomy between 2012 and 2022 were retrospectively reviewed. Eyes with PPC size smaller than the anterior capsulotomy size were considered as group 1. Eyes with PPC size larger than the anterior capsulotomy size were considered as group 2. Clinical characteristics, the need for Nd:YAG laser treatment or further surgery for significant VAO, and other postoperative complications were compared between the groups.

Results:

Sixty eyes of 41 children were included in the study. The median age at the time of surgery was 5.5 and 3 years in groups 1 and 2, respectively (
P
= .076). Primary intraocular lens implantation was performed in 23 (85.2%) eyes in group 1 and 25 (75.8%) eyes in group 2 (
P
= .364). There was no difference between the groups in terms of postoperative visual acuity (
P
= .983) and refractive errors (
P
= .154). Eight (29.6%) pseudophakic eyes received Nd:YAG laser treatment in group 1, but none of the eyes in group 2 (
P
= .001). Four (14.8%) eyes in group 1 and 1 (3%) eye in group 2 underwent further surgery for VAO (
P
= .100). The need for further intervention for significant VAO was statistically higher in group 1 (44.4% vs 3%,
P
< .001).

Conclusions:

Larger PPC size in pediatric cataract may reduce the need for further intervention for significant VAO.

[
J Pediatr Ophthalmol Strabismus
. 2023;60(6):441–447.]
Comparison of the Ahmed and Baerveldt Glaucoma Drainage Implants in the Treatment of Primary Congenital Glaucoma
Authors: Badawi Abdulrahman H. , Al Owaifeer Adi Mohammed , Mofti Alaa , Al-Shahwan Sami , Al Jadaan Ibrahim , Malik Rizwan
Published: February 2023

Purpose:

To compare the outcomes of the Ahmed glaucoma valve (AGV) (New World Medical, Inc) with the Baerveldt glaucoma implant (BGI) (Johnson & Johnson Vision) in primary congenital glaucoma (PCG).

Methods:

This was a retrospective review of children with PCG who underwent AGV or BGI implantation with a minimum follow-up of 6 months. Main outcome measures were intraocular pressure (IOP), the number of glaucoma medications, success rate, complications, and surgical revisions.

Results:

The study included 153 eyes of 86 patients (120 eyes in the AGV group and 33 eyes in the BGI group), and the mean follow-up period was 58.7 ± 6.9 months in the AGV group and 58.5 ± 5.0 months in the BGI group. At baseline, IOP was lower in the AGV group (33 ± 6.3 vs 36.4 ± 6.1 months;
P
= .004) and the number of glaucoma medications was comparable between groups (3.4 ± 0.9 vs 3.6 ± 0.5 medication;
P
= .183). At 5 years, the mean IOP (18.4 ± 5.0 vs 16.3 ± 2.5 mm Hg;
P
= .004) and number of glaucoma medications (2.1 ± 1.3 vs 1.0 ± 1.0 medication;
P
= .001) were significantly less in the BGI group. Furthermore, the surgical success was 53.4% in the AGV group and 78.8% in the BGI group (
P
= .013).

Conclusions:

Both the AGV and BGI were successful in providing adequate IOP control in patients with PCG. Long-term follow-up showed that the BGI was associated with a lower IOP, fewer glaucoma medications, and a higher success rate.

[
J Pediatr Ophthalmol Strabismus
. 2023;60(6):448–454.]
Design of a control mechanism for the educational management automation system under the Internet of Things environment
Authors: Liu Yuanfu , Liu Yi
Published: February 2023

Since the entrance of the Internet era, management automation has been an inevitable tendency in many areas. Especially, the great progress of Internet of Things (IoT) in recent years has provided more convenience for basic data integration. This also boosts the development of various management automation systems. In this context, this paper takes physical education as the object, and proposes the design of a control mechanism for educational management automation systems under the IoT environment. First, a description with respect to the overall design, detailed design, and database design is given. In addition, a low-consumption flow table batch update mechanism is studied, which packages and distributes the update rules of all nodes to be updated, in order to reduce the communication consumption between the controller and nodes. The results show that the education management automation of the college gymnasium can be well realized by using the optimization control mechanism. It cannot only make reasonable adjustments to college sports resource data, basic equipment, etc., but also improves the quality of resource management of college physical education courses to ensure that college sports resources can be used in all aspects, and further improves the operating efficiency of the sports management system. The automation technology design of the college sports management system can improve the efficiency of college sports management by more than 20%, so as to ensure the comprehensive development of students in physical education courses and promote the rapid improvement of college management level.
Impact of Gender Diversity on the Board of Directors on the Financial Performance of the Chinese Private Water Companies
Authors: Reza Rajibur , Sun Lan
Published: February 2023

China is facing an acute portable water problem and presents a picture of severe supply constraints. Thus, China's water crisis offers attractive business opportunities for foreign water companies as well as domestic private water companies. Hence, the private sector participation in the Chinese water sector is a hot topic. This chapter investigates the impact of gender diversity on board of directors on the financial performance of the Chinese private water companies using ordinary least squares (OLS) and unbalanced panel (random effects) regression models, which are estimated as the baseline approach on a sample of 19 Chinese private water companies for the period of 2010-2017. The OLS and random effects results show that number of women on board (WB), percent of women on board (%WB), number of female executives (FE), and percent of female executives (%FE) affect the Chinese water companies' financial performance. The results of this chapter are important for researchers, regulators, and policymakers to benefit from policies that encourage board varieties at an individual water company level.
Mindfulness-based Therapy for management of Female Sexual Dysfunction and Psychological Well-being
Authors: Gupta Kavita , Patel Ashok Kumar
Published: February 2023

Female sexual dysfunction (FSD) is a common disease that affects many women, and there are few therapeutic options available. Female sexual dysfunction is a progressive and prevalent illness that affects more women as they get older. Reduced vaginal lubrication, soreness and discomfort during intercourse, a decreased sense of excitement, and difficulties achieving orgasm are all common signs of female sexual dysfunction. Only a small percentage of women seek medical help. In comparison to the vast amount of study and treatment for erectile dysfunction in men, female sexual dysfunction has received far less attention, with treatment mostly consisting of psychological therapy. The aim of the chapter is to provide the most current knowledge on female sexual dysfunction, advances in basic science addressing this dysfunction, and explore developing therapeutic options.
Consequences of Stress
Authors: Sharmen Haiqa , Baloch Akhtar , Faridi Adnan
Published: February 2023

The purpose of this chapter is to investigate the consequences of occupational stress on human life. The present report aims to find out several behavioral, organizational, and medical health issues related to organizational stress. The purpose of this work is to develop a theoretical integrative consensus in the field of stress modes. The current study is designed as a systematic review. Subjective relevance to study keywords (stress, stress management, chronic stress, community stress, group stress, stress growth, stress adverse effects, stress sources, stress phases, stress categories) published by academic and/or scientific resources are used as inclusion criteria. Content analysis is used to gather data. The goal of this work is to provide a theoretical unity of approach in stress research. According to the findings, more research is needed into additional areas of stress, such as social, emotional, gender-related, ethnic, or physical consequences of stress along with specific professions, such as teaching, pilots, accountants, and so on.
Investigating the Effect of Coping Strategies and Resilience Towards Stress Among Single Mothers in Terengganu, Malaysia
Authors: Talib Jasmi Abu , Mohamad Zakaria , Raji Nurul Atiqah Ab , Saputra Jumadil , Husain Zuhda , Yusof Raba'Aton Adawiah Mohd , Ramley Fazliyaton , Dagang Mazidah Mohd , Noor Marhaini Mohd
Published: February 2023

Single mothers must play double roles as mothers and the head of the family. They must deal with many challenges to survive. Thus, this study aims to investigate the effect of coping strategies, and resilience on stress among single mothers in Terengganu, Malaysia. This quantitative study involved 328 single mothers in the Kuala Nerus of Terengganu. The data was collected purposively through surveys questionnaire. This study found that resilience has a negative and significant effect on stress. Besides that, the coping strategies (e.g., problem-centred behavior and avoidant behavior) have a significant effect on single mother stress. Social-supported behavior and emotion-centred behavior do not have a significant effect on stress. In conclusion, this study has identified the level of coping strategies, resilience, and stress. Also, the authors indicated that resilience has negative effects and coping strategies (e.g., problem-centred behavior and avoidant behavior) have positively affected single mothers' stress in Terengganu, Malaysia. A few recommendations were proposed based on the findings.
Technostress Among Academics in Higher Education During the COVID-19 Pandemic
Authors: Wong Evelyn Mei Ling , Leow Kenneth , Leow Serena
Published: February 2023

The adoption of new technologies has revolutionized teaching and learning in higher education institutions (HEIs) in the last few decades, particularly during the recent pandemic crisis. Although the adoption of technology affords many benefits and conveniences to educators and students, increasing evidence has highlighted the escalating stressors connected to the adoption of technologies in and beyond classrooms for academics. This phenomenon is also coined as technostress, which refers to a “disease of adaptation” caused by an individual's failure to cope with technological change in a healthy way. The struggle to adapt to technological changes can directly or indirectly impact academics' physical health, mental and psychological well-being, and job performance. Therefore, this chapter aims to 1) understand what is technostress, (2) identify sources of technostress, (3) examine technostress in higher education (HE), and (4) highlight strategies to mitigate technostress.
Applications of Watermarking in Different Emerging Areas
Authors: Kumar Lalan , Kumar Ayush , Kumar Shravan , Kumar Indrajeet
Published: February 2023

These days enormous amounts of information is at almost everyone's disposal with a single click of a button, and that too on a hand held device. Data can be present in various forms like still images, and slides of pictures like a video of GIF, over various websites present on the Internet. Because of the excessive use of this data, it also becomes important to secure it as it can be duplicated, transformed, stolen, tampered, or misused pretty easily. Recently, there has been a spike increase in the use of medical images in various E-health applications. In order to counter these potential threats, a number of watermarking techniques are being developed. A watermark is embedded in an image or document in the form of an image or pattern that can be used to authenticate the integrity of the image in question. As time goes by, the complexity of the problems that we are dealing with also keeps on increasing.
Expectations, Culture, and Adaptation to Higher Education Institutions by First-Year Students
Authors: Aloka Peter Jo , Opondo Christine Mwajuma , Ooko Mary
Published: February 2023

This chapter analyzed expectations, culture, and adaptation to higher education institutions by first-year students. By adopting a conceptual review as framework, data were obtained from published literature. The results presented in the chapter indicated that most first-year students have unrealistic expectations and that the university culture often presents new and confusing expectations to the majority of first-year students. Moreover, many students are still starting their experience with either high or unrealistic expectations for what to expect during their first year of university. It is recommended that the managers of universities should develop more positive alignment between perceived expectations and levels of student satisfaction with the quality of their experience.
Adapting to the Academic Environment
Authors: Suditu Mihaela , Safta Cristina-Georgiana
Published: February 2023

The present study is based on the desire to investigate the possible relationship between the level of adaptation of the students to the university environment and the registration of academic performance. The working hypothesis is, if the level of adaptation to the university environment is high then the level of performance increases. Operationally, the concept of adaptation integrates the following dimensions: motivation, application, performance, satisfaction, academic environment. For the present research, the authors consider only the first subscale of Student Adaptation to College Questionnaire, respectively the academic adaptation, reflected, in turn, in the following indicators: motivation, application, performance, academic environment. The correlation of the data—for the above-mentioned subscales—will generate a qualitative analysis of the degree of satisfaction of students and how it is reflected in academic achievement. The obtained results will allow building strategies to streamline the approach of academic integration with effects on increasing performance.
Peer Support and Adjustment Among First-Year Students at University
Authors: Otieno Kennedy
Published: February 2023

Peer support and adjustment among first-year students at university will help them overcome difficulties they face in their academic journey. The challenges facing first-year students at the university include home sickness, freedom of transition to university life, time management, budgeting, partying, and the cost of education. The current study adopted literature review as the methodology in order to analyze secondary data. The researcher sought to objectively and rationally review empirical studies from reputable education sites such as Google Scholar, Educational Resources Information Center (ERIC), and JSTOR. The data were analyzed qualitatively by using content analysis where only the main ideas of the key findings were considered. The study established that parental and peer support received among first-year students have contributed towards their adjustment at universities.
Mediatization of the Task in the Teaching/Learning of French as a Foreign Language
Authors: El Abidine Mohammed Zine , Nejjari Amel , Khaldi Mohamed
Published: February 2023

At a time when the use of information and communication technologies for teaching (ICTE) is spreading and pedagogical platforms are multiplying, a remarkable challenge corroborates this reflection, that is the integration of these ICTE in the teaching and learning of French as a foreign language. ICTE is crucial because it is an important element that influences educational and organizational practices. The chapter proposes to address the issues related to the contribution of ICTE in the teaching/learning of French as a foreign language starting from the approach centered on “the task” and on “the pedagogical scenario.” French as a foreign language submits students to a remarkable challenge when they consider the use of information and communication technologies in their teaching. From this perspective, the main objective is to conduct research on the use of ICT in order to propose mediated tasks in the actional perspective favored by the common European framework of reference for languages (CEFR).
Emulsifiers in diets with energy reduction for laying hens
Authors: Oliveira Marllon José Karpeggiane de , Geraldo Adriano , Lemke Sara Santana Ramos , Valentim Jean kaique , Fassani Édison José , Carvalho Jordanna Barbosa Ferreira De , Miranda Diogo Alvarenga , Silva Eliane Aparecida
Published: February 2023

Emulsifiers in animal diets are an interesting and effective strategy for nutritionists to improve the digestion of dietary lipids and, consequently, provide better performance. This study aimed to evaluate the effect of the supplementation of diets with emulsifier based on mono- and diglycerides (120 g t-1 of feed) associated with different energy levels (2,775; 2,725; 2,675 and 2,625 kcal of metabolizable energy kg-1 of feed) on performance and egg quality of Hisex Brown laying hens. The laying hens were distributed in 50 experimental plots with eight birds each. A completely randomized design with five treatments and ten replicates/treatments was used. The treatments in this study were: control diet (C) with 2,775 kcal of metabolizable energy (ME) kg-1 of feed; C + E: diet C supplemented with an emulsifier (E) at 120 g t-1 of feed; diet C with reduction of 50 kcal ME and supplemented with E (NC50 + E); diet C with reduction of 100 kcal ME and supplemented with E (NC100 + E); and diet C with reduction of 150 kcal ME and supplemented with E (NC150 + E). All diets had the same inclusion level of degummed soybean oil (2%). There was no influence of the treatments on the performance and quality of the eggs (p >0.05). The current study has shown that diets supplemented with emulsifiers based on mono- and diglycerides (120 g t-1) allows reducing the metabolizable energy level up to 150 kcal kg-1 of feed, without impairment on performance and egg quality of Hisex Brown laying hens
Fabrication of Vinyl Functionalised Multiwalled Carbon Nanotubes for the Removal of Organic Pollutant
Authors: Sreelakshmi T.R. , Sajini T. , Mathew Beena
Published: February 2023

A novel and convenient approach for the fabrication of vinyl functionalized multiwalled carbon nanotube (MWCNT) as a sorbent for organic pollutant is described in this article. In this method, the purified MWCNT is functionalized via a non-covalent strategy using 9-vinyl anthracene, fluorescent active species. The synthesised nanotube was characterised using various techniques such as Fourier transform infrared spectroscopy (FT-IR), UV-Vis. spectroscopic analysis, scanning electron microscopy (SEM), X-ray diffraction technique (XRD), thermogravimetric analysis (TGA), transmission electron microscopy (TEM) and Raman spectroscopy. Effects of concentration, pH and time for the functionalization of MWCNTs were investigated through photoluminescence (PL) studies. The resulting vinyl functionalized MWCNT will act as a promising adsorbent for organic pollutants like p-chlorobenzoic acid.
The Energy Potential of Glassy Volcanic Rock for Cellular Glass Production
Authors: Sahakyan Emma , Kalantaryan Marine
Published: February 2023

A thermodynamic model for cellular glass pore-formation has been developed on the basis of natural volcanic silicate and aluminosilicate glasses. The energy expenses for heating the materials, chemical reactions, breaking the structural bonds of water hydrates, evaporation of the released water, and pore formation of the glass mass are determined sequentially. The enthalpy and Gibbs energy of the complex gas-forming agent HNO3 + SiC are calculated.
Tricuspid Regurgitation Etiologies, Current Diagnostic Methods, and Management
Authors: Al Haroun Retaj , Dashti Raja , Rajan Rajesh , Al Jarallah Mohammed , AI Mulla Khalid , Al Balool Joud , Kobalava Zhanna Davidona , Talukder Suprateeka , Evbayekha Endurance Osas , Tse Gary , Huang Helen
Published: February 2023

Tricuspid regurgitation (TR) is a common finding. Any changes to the components of the tricuspid valve (TV), such as the tricuspid annulus, valve leaflets, papillary muscles, and chordae tendinae can lead to TR. This valvular disease has recently sparked interest after it was long forgotten. This paper examines the anatomy of the TV, etiology of TR, and critically appraises the diagnostic methods used to assess the TV and the current medical treatment options for TR. This paper aims to give a detailed review of TR in hopes that more research will be conducted to help better assess patients with tricuspid regurgitation.
GATA-binding Protein 4 Promotes Neuroinflammation and Cognitive Impairment in Aβ1–42 Fibril-infused Rats through Small Nucleolar RNA Host Gene 1/miR-361-3p Axis
Authors: Liu Lidan , Peng Yanhui , Liu Wenping , Xu Jiajun , Li Dali , Li Xiuwen
Published: February 2023

Aging with dysregulated metabolic and immune homeostasis stimulates pyroptosis, neuroinflammation, and cellular senescence, thus contributing to etiopathogenesis of Alzheimer's disease. GATA-binding protein 4 (GATA4) functions as a transcriptional factor in response to DNA damage, and is associated with neuroinflammation and cellular senescence. The role of GATA4 in Alzheimer's disease was investigated. GATA4 was elevated in hippocampus of Aβ1–42 fibril-infused rats. Injection with shRNA targeting GATA4 reduced escape latency with increase of time in target quadrant and number of platform crossings in Aβ1–42 fibril-infused rats. Moreover, knockdown of GATA4 ameliorated morphological changes of hippocampus and reduced amyloid plaque deposition in Aβ1–42 fibril-infused rats. Silence of GATA4 repressed neuroinflammation and apoptosis in Aβ1–42 fibril-infused rats. Loss of GATA4 in Aβ1–42 fibril-infused rats reduced the expression of specificity protein 1 (Sp1) to downregulate long noncoding RNA small nucleolar RNA host gene 1 (SNHG1) and upregulated miR-361-3p. Loss of SNHG1 ameliorated learning and memory impairments in Aβ1–42 fibril-infused rats. Overexpression of Sp1 attenuated GATA4 silence-induced decrease of escape latency, increase of time in target quadrant, and number of platform crossings in Aβ1–42 fibril-infused rats. In conclusion, silence of GATA4 ameliorated cognitive dysfunction and inhibited hippocampal inflammation and cell apoptosis through regulation of Sp1/SNHG1/miR-361-3p.
Protocatechuic Acid Reduces H2 O2-induced Migration and Oxidative Stress of Fibroblast-like Synoviocytes in Rheumatoid Arthritis by Activating Nrf2-Keap1 Signaling Pathway
Authors: Liu Yan , Zhang Yucheng , Zhang Keke , Wang Yue
Published: February 2023

Honeycomb (Nidus vespae) is traditional Chinese medicine and can treat rheumatoid arthritis (RA), and protocatechuic acid (PCA) is a bioactive component of honeycomb. This study aimed to investigate whether PCA could reduce the H2O2-induced migration and oxidative stress of RA fibroblast-like synoviocytes (RA-FLSs). H2O2-induced RA-FLSs were used to simulate the in vitro model of RA. The viability, apoptosis, migration, invasion, and oxidative stress of RA-FLSs were detected by Cell Counting Kit-8 (CCK-8), terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, wound healing, transwell assays, DCFDA staining, and malonaldehyde and superoxide dismutase enzyme-linked immunosorbent assay kits. The expression of migration and invasion-related proteins and Nrf2/Keap1 signaling pathway-related proteins was analyzed by western blotting. As a result, PCA suppressed the viability, migration, invasion, and oxidative and promoted apoptosis of H2O2-induced RA-FLSs by activating the Nrf2/Keap1 signaling pathway. ML-385, an Nrf2 inhibitor, could enhance the viability, migration, invasion, and oxidative and inhibited apoptosis of H2O2-induced RA-FLSs. In conclusion, PCA reduced H2O2-induced migration and oxidative stress of RA-FLSs by activating the Nrf2-Keap1 signaling pathway.
Health Effects of Fifth-Generation Technologies
Authors: Ramakrishnan Mani , Athikary Kunal G.
Published: February 2023

The advancement of telecommunication technology is vital for our wireless connectivity and networking across the world, but not at the expense of the lives of other organisms because their extinction follows us. This review article highlighted the various communication systems and technologies implemented and their implications. The relevant keywords used for this review, including fifth generation (5G), electromagnetic radiation (EMR), telephone tower, 5G impacts on lives, 5G impacts on human health, animals, and birds, were used for inclusive search on trustworthy citation databases listed in Scopus, PubMed, Web of Science, and Google Scholar from 1993 to 2022. The findings revealed that the radiations range between radio frequency and electromagnetic frequency is causing detrimental effects on different species including their fertility and fetus development. Experts reported that birds use the earth's EMR to navigate in their flight, but when they are exposed to weak or microwave radiation from the telecommunication towers, they deviate from their path, confused, and even die from telephone tower collisions. The new movement in protecting the bird population from EMR is creating an awareness of "air as a habitat" for birds, and research reports show that it is experimentally proven, that such radiations affect the birds' lives in many ways. Authors believe that these critical surveillance data would create awareness among the readers and researchers about the consequences to human health due to the extensive use of new generation telecommunication and networking technologies. The World Health Organization mentioned the harmful effects of EMR in their report. It shows that a diffuse collection of symptoms such as headaches, anxiety, suicide and depression, nausea, fatigue, and loss of libido may be caused due to low levels of exposure to EMR at home.
Herpes endotheliitis following laser-assisted in situ keratomileusis and photorefractive keratectomy
Authors: Moshirfar Majid , Ziari Melody , Peterson Christian , Kelkar Neil , Ronquillo Yasmyne , Hoopes Phillip
Published: February 2023

Herpes endotheliitis is a less common manifestation of herpes keratitis, and characteristic examination findings include corneal edema and the presence of keratic precipitates. Infection may be primary or secondary to herpes virus reactivation following exposure to a potential trigger such as physiologic stress or environmental factors. Ocular surgery, including laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK), can trigger reactivation in patients with or without a documented history of previous herpes infection. We present two patients with visually insignificant stromal scarring who denied a previous history of herpetic disease and developed herpes endotheliitis following LASIK and PRK. We demonstrate the importance of an appropriately thorough preoperative evaluation and further workup of any corneal abnormalities, even if such findings initially appear inconsequential.
Comparison of Holmium
Authors: Kuo Chih-Chun , Kuei Chia-Hao , Liao Chun-Hou , Lin Yu-Hua
Published: February 2023

Purpose:

To evaluate the use of the Holmium: Yttrium-aluminum-garnet (YAG) laser versus the conventional dorsal-slit procedure for adult male circumcision.

Materials and Methods:

From January 2020 to December 2020, 60 adult men diagnosed with as having phimosis and received circumcision were enrolled. Patients received either Holmium: YAG laser circumcision or conventional circumcision. In this study, we assessed the difference between the groups.

Results:

Although the operative time and blood loss decreased more in the Holmium: YAG laser circumcision group than in the conventional circumcision group (P < 0.001), a longer short-term delay in wound healing was observed in the laser circumcision group than in the conventional circumcision during the follow-up course (20.0% vs. 3.3%, P = 0.04). Our results also demonstrated no significant difference between the two groups in pain control, postoperative prepuce edema, prepuce redundancy, infection, or hematoma occurrence (P > 0.05). Microscopy findings of the resected prepuce in the Holmium: YAG laser circumcision group demonstrated a high percentage of coagulated small capillaries near the cutting edge.

Conclusion:

The holmium laser seems to be a concrete and feasible option for circumcision. Although patients undergoing holmium laser circumcision benefit from less blood loss and a rapid surgery compared to the conventional procedure, there is a higher risk of poor wound healing in short-term follow-up.
Spatial and Temporal Diversity Variation in the Anopheles Communities in Malaria-Endemic Regions of Colombia
Authors: Naranjo-Díaz Nelson , C. Hernández-Valencia Juan , F. Gómez Giovan , M. Correa Margarita
Published: February 2023

This study aimed to evaluate at a temporospatial scale, the influence of anthropogenic land cover changes in the Anopheles species community composition and diversity in two Colombian malaria-endemic regions, Bajo Cauca and Pacific. To determine variations over time, mosquitoes were collected in two time periods; land cover types were characterized on orthorectified aerial photographs, and landscape metrics were estimated for each locality and period. A temporal dissimilarity analysis to evaluated species replacement and the nestedness species loss/gain showed the influence of the species loss or gain component on Anopheles species assemblage (23%). The relationship between land cover variation and Anopheles beta diversity, evaluated by regression analysis, showed the effect of forest variation in the Anopheles community (βsim and forest r2 = 0.9323; βsne and forest r2 = 0.9425). Furthermore, a canonical correspondence analysis showed that the land cover types associated with Anopheles species presence were bare soil, shrub, wet areas, and forest. Results demonstrated the impact of land cover changes attributed to human activities on Anopheles population dynamics, over time; this was evidenced as species loss or gain, which was specific to each locality. Notably, the main malaria vectors were dominant in most localities over time, suggesting their tolerance to anthropogenic transformations; alternatively, the environmental changes are providing adequate ecological conditions for their persistence. Finally, the data generated are relevant for understanding the impact that environmental change may have on the dynamics of the neotropical malaria vectors. Thus, this research has potential implications for vector control interventions.
Fractional Abel Differential Equation Application in Edge Detection: FADEED
Authors: Nithyadevi N. , Prakash P.
Published: February 2023

There is a long history of perturbed implementations of Abel differential equations in dynamics, linear systems with stochasticity, modeling approaches, and linear algebra. Numerous research has been undertaken, the bulk of which have focused on Abel differential equation techniques and the use of the Abel differential equation using the variation iteration method. Edges define boundaries and are hence of primary relevance in image processing. Edge detection removes unnecessary data, noise, and frequencies from a picture while maintaining crucial structural aspects. To extract edges based on canny, the suggested technique employs fractional Abel differential equation (FADE) logic. In this case, a picture is used with the windowing technique and is submitted to a series of Abel differential equations. The purpose of this research is to assess the performance of a FADE system in edge detection. The results produced by the linear canny operator are compared to those obtained with pictures with substantial contrast variation. This experimental investigation will provide a faster procedure and a better output image than the current methods. The main goal of the proposed technique is to use the edge points and the information they collect for edge identification, resulting in faster and more accurate results. For all of the experimental experiments, MATLAB software was employed.
Students’ Perceptions of the Effectiveness and Challenges of Online EFL Assessment in Libya during the Covid-19 Pandemic
Authors: Baresh Eman Fathia
Published: February 2023

Online platforms have been embraced in the teaching and learning of English as a second and foreign language in almost every country in the world.  Many studies have found out that the online medium is effective in the ESL/EFL teaching and learning. However, the area or assessment is still a challenge to many teachers and students in ESL/EFL teaching and learning. Therefore, this study investigates the Libyan undergraduates’ perceptions of online assessment. A survey research design is adopted for the study. Data were collected from 105 Libyan undergraduates from six universities using a questionnaire. The data were analysed using descriptive statistical analysis. The findings reveal that the students have positive perceptions towards online assessment because it is convenient, flexible and give instant feedback. In addition, the findings show that the online assessment motivates them to learn subject matter. They prefer the online assessment than the traditional assessment because online assessment is suitable for all subjects and students respectively. It enhances technical skills as well as self-learning skills. Many Libyan undergraduates are motivated and aware of the benefit of online assessment. On the other hand, the findings indicate that the students perceive online assessment to facilitate cheating among students.
Roman Analysis of Tenggelamnya Kapal Van Der Wijck by Hamka through Critical Literature Approach
Authors: Ahmad Ridhai Asis  , Burhanuddin
Published: February 2023

This study aims to describe the results of the analysis of the Roman Tenggelamnya Kapal Van Der Wijck by Hamka. This research approach used a critical literacy approach to criticize the meaning or purpose of the author expressing his message through a symbolic romance. The results of this study indicated that : (1) Hamka presented events through the theme of an unsuccessful love story/unacceptable love story which critically symbolized the desire for independence of the natives of colonialism that had not been conveyed ; (2) The plot used combines the loose groove and the back-and-forth groove which critically symbolizes a long and winding to struggle ; (3) The point of view used was third person singular which was a feature of the author's symbolic expression that criticized government associability ; (4) The characters of the novel created by the author symbolized by the indigenous context at that time critically symbolizing fighters and allies as well as invaders that were always in conflict ; (5)  The message conveyed was a moral message that focused on the character of Zainuddin who struggled on differences of ethnicity, customs, and ideology which critically symbolized the struggle which in context at that time was not yet fully independent from colonialism
Breast Screening in Singapore: Implications for Pathology
Authors: Tan Puay-Hoon
Published: February 2023

The aim of this review is to discuss the impact of breast screening on pathology. The advent of the national mammographic screening programme in Singapore has led to changes in the manner in which breast specimens are handled in the pathology laboratory, an increased detection of borderline lesions which pose diagnostic challenges, the occurrence of specific issues regarding core biopsies, and the need for awareness of histologic artefacts associated with preoperative needling procedures. There are also economic and workload implications, in addition to the essential requirement for quality assurance and educational programmes to maintain high professional standards. A multidisciplinary approach and commitment to continual professional upgrading are key to surmounting the pathologic challenges brought about by breast screening. Key words: Borderline lesions, Quality assurance, Radiologic calcifications, Workload
Cluster of Staphylococcus aureus and Dengue Co-infection in Singapore
Authors: Chai Louis YA , Lim Poh-Lian , Lee Cheng-Chuan , Hsu Li-Yang , Teoh Yee-Leong , Lye David CB , Krishnan Prabha , Leo Yee-Sin
Published: February 2023

Introduction: Singapore saw a resurgence of dengue infections in 2005. Concurrent bacterial co-infections in dengue is rare.
Clinical Picture: We report a cluster of serious methicillinsusceptible Staphylococcus aureus (MSSA) bacteraemia or severe soft tissue infection in 5 epidemiologically linked construction workers presenting with dengue and non-resolving fever.
Treatment: Surgical intervention was indicated in 4 of the 5 patients despite appropriate antistaphylococcal therapy.
Outcome: All but 1 patient were eventually discharged. Clonality and Panton-Valentine leucocidin genes were not demonstrated. Epidemiological investigations suggested that occupational contact dermatitis could have predisposed the patients to this opportunistic co-infection.
Conclusion: Clinicians need to be vigilant to unusual manifestations of dengue which may signal a concomitant aetiology.

Key words: Dengue epidemic, Dermatitis
Peripartum Acute Anterior ST Segment Elevation Myocardial Infarction: An Uncommon Presentation of Acute Aortic Dissection
Authors: Omar Abdul Razakjr , Goh Wei-Ping , Lim Yean-Teng
Published: February 2023

Introduction: Atherosclerotic coronary artery thrombosis is the most common cause of acute myocardial infarction.

Clinical Picture: A 30-year-old lady presented with acute peripartum massive anterior ST segment myocardial infarction and cardiogenic shock. This was due to acute Stanford type A aortic dissection with the intimal flap occluding the left coronary ostium. The initial diagnosis was not apparent. Echocardiography confirmed the diagnosis.

Treatment and Outcome: She underwent emergency surgical repair (Bentall procedure). Pathology confirmed underlying idiopathic cystic medial degeneration.

Conclusion: A high index of clinical suspicion is required in acute myocardial infarction presenting without traditional cardiovascular risk factors.

Key words: Acute anterior myocardial infarction, Cystic medial degeneration
Clear Cell Carcinoma of Minor Salivary Gland – Case Report
Authors: Ponniah Irulandy , Kumar Palani Suresh , Karunakaran Kaliappan
Published: February 2023

Introduction: Clear cell carcinoma is a rare low-grade carcinoma that almost exclusively occurs in the minor salivary glands. This tumour is one of the new additions in the recent World Health Organization (WHO) classification of salivary gland tumours.

Clinical Picture: A 50year-old woman presented with a gradually enlarging painless submucosal mass of 3 months’ duration over the left side of the palate.

Treatment and Outcome: A preoperative diagnosis of primary clear cell carcinoma of salivary gland with focal surface epithelial dysplasia was rendered after thorough clinical examination to rule out renal origin. The lesions were excised with wide surgical margins and 3 years into the postoperative period, the patient was disease-free.

Conclusion: We report a case of clear cell carcinoma of intra-oral minor salivary gland and draw comparisons with metastatic clear cell carcinoma of renal origin.

Key words: Hyalinising stroma, Renal cell carcinoma
Remembering the Musi – SilkAir Flight MI 185 Crash Victim Identification
Authors: Tan Peng Hui , Wee Keng Poh , Sahelangi Peter
Published: February 2023

On 19 December 1997, SilkAir Flight MI 185, a Boeing B737-300 airliner crashed into the Musi River near Palembang, Southern Sumatra, enroute from Jakarta, Indonesia to Singapore. All 104 passengers and crew onboard were killed. Of the human remains recovered, 6 positive identifications were made, including that of one Singaporean. Two of the identifications were by dental records, 2 by fingerprints, 1 by age estimation and 1 by personal effects. This paper describes the crash victim identification of Flight MI 185. The authors were part of an Indonesia-Singapore forensic team deployed for 3 weeks in Palembang to assist the Indonesian authorities in human remains identification.

Key words: Boeing 737, Dental radiology, Disaster victim identification, Forensic odontology