bluuebunny/crossref_metadata_2025 huggingface dataset:
Socio-Legal Empowerment for Working Women in Bangladesh
Authors: Ahmed Fauzia Erfan , Parajuli Jyotsana , Feldman Anna Lucia
Published: September 2023

Abstract: Violence against working women strikes at the heart of economic empowerment programs—the very programs that are intended to empower them. If economic empowerment is defined as women's control over their income, violence as patriarchal deterrence prevents those women from controlling the money that they have worked so hard to earn. Therefore, women who earn are not inevitably empowered through their participation in the labor force. We argue that economic empowerment cannot be defined in terms of women's labor force participation alone. Gender-based violence sustains patriarchy. As part of the development of sociolegal empowerment theory, we introduce patriarchal deterrence as a new concept, which goes in tandem with patriarchal backlash theory, further clarifying analyses of low female labor force participation. As patriarchal backlash, violence punishes women who have joined the workforce; as patriarchal deterrence, it deters women from even starting to work. Arguing that income generation is insufficient, we present a theory of socio-legal empowerment as a necessary corollary of economic empowerment, which integrates concepts of legal empowerment and social accountability. Our theory has four components, which can be applied to assess a justice system. First is societal embeddedness, which measures how context-specific it is. For example, in Muslim countries, informal justice systems, which utilize feminist interpretations of Islam, are more embedded in local values and therefore more effective. By analyzing feminist interpretations of Islam as an imperative measure of effective justice systems for Muslim communities, we challenge Orientalist binaries of Islam versus women's rights. Second is social accountability, which assesses whether its verdicts and processes have social sanction. Third is its gender transformativeness, or social change potential, which addresses its capacity to build awareness. Fourth is its costs not only in terms of legal expenses but also of physical proximity which eliminates childcare expenses. In sum, we illustrate that earning income, though necessary, is insufficient for women's economic empowerment. Through the analysis of the NGO-ReformedShalish (informal justice system) in Bangladesh, we illustrate how socio-legal empowerment, in theory and practice, is also needed to empower working women.
Organic Transitioning and Queer Topophilia in Paul Takes the Form of a Mortal Girl
Authors: Belmont Cynthia
Published: September 2023

Abstract: Andrea Lawlor's (2017) historical picaresque novel Paul Takes the Form of a Mortal Girl tracks the ephemeral embodiments and identifications of Paul Polydoris, a gender-fluid, shape-shifting anti-hero who adapts to queer environments across the United States during 1993–1995, a time when gay hedonism, lesbian feminism, punk anti-homonormativity, and LGBTQ responses to AIDS combined to make a complex heyday of queer culture. Paul exemplifies "organic" transitioning in that his gender processes complicate the culture/nature binary, resist anthropocentrism, emphasize empathetic interrelation with other organisms, and privilege understanding of the complex involvement of biology, culture, and individual will in transition. Paul's body is an enchanted site of meaning that is created in situ and in which he is then positioned to participate in local culture, moving the concept "sense of place" from green trope to queer fantasy of limitless engendering. Approaching the novel from a queer ecological/ecofeminist perspective, this paper argues that as a magical, marginal bricoleur who assembles performative selves from biological forms and cultural references via passionate liminal engagement with queer spaces, Paul inhabits a self-directed transness that challenges conventional understandings of the "natural" and the "human," modeling a dynamic, queer topophilia.
Mamá Osa in the Mountains: African Ascendientes' Embodiments of Fugitivity and Freedom in the Americas
Authors: Boveda Mildred
Published: September 2023

Abstract: Women who are multiply marginalized find innovative ways to conjure prestige and assert their dignity within oppressive societies. In this essay, I apply a Mami-informed de/colonial approach to analyze the life of one such woman: my grandmother Rosa. In 1936, Rosa (Mamá Osa) moved to the sierras of Sánchez, Samaná, Dominican Republic to resist the anti-Black patriarchy she experienced. By sharing my grandmother's story, I underscore the value of multiply marginalized women being in community with one another as a counterpoint to the liberal goal of integration. I draw parallels between the oral history of her decision to start a new life in the mountains and the written accounts of the sixteenth- and seventeenth-century maroon communities of the Americas. I also examine Dominican feminist writings during my grandmother's era to contextualize her life narrative. In making explicit how past Dominican feminist and pedagogical discourse were inaccessible and marginalizing to freedom-seeking women like my grandmother, I urge scholars who trace knowledge systems around the world to continue to examine the sources of feminist thought.
Anaysis of Interest Rate Spread, Financial Development and Foreign Capital Inflow Nexus in Nigeria
Authors: Orji Anthony , Ogbuabor Jonathan E. , Anthony-Orji Onyinye I. , Monye Ebelechukwu G.
Published: September 2023

ABSTRACT: The world has gone through various economic crises in the past century, and their effects have had varying implications on the economies of countries all over the world. In a bid to help stabilise economies all over the world, various measures have been put in place. Some of these measures include regulations and policies by the Bretton Woods institutions (World Bank and International Monetary Fund) and their agencies. The idea behind these measures is to ensure sustainable growth and development among member states and other countries of the world. Some of these policies include the privatization and liberalization policies of the Bretton Woods institutions as well as other policies bordering on such economic and social benefits for people all over the world. The Nigerian economy in our contemporary time can be described as passing through a rather 'volatile' phase with respect to interest rate, financial development and foreign capital inflow. Thus, this study investigated the impact of interest rate spread and financial development on foreign capital inflow in Nigeria. Several studies have been carried out using different methodologies, such as; co-integration equation, multivariate vector auto regressive (VAR) model and vector error correction technique. Each methodology used was in line with the objective of the research in question. However, to achieve its objective, this paper adopted the Classical Linear Regression Model. The results of the study showed that financial development has a positive impact on foreign capital inflow, while interest rate spread on the other hand, was also found to have a positive impact on foreign capital inflow. Other control variables such as market capitalization and treasury bills rate were also found to positively affect foreign capital inflow, while the all share index had a negative impact on foreign capital inflow. Some economists have opined that the Nigerian economy is currently going through a phase of recession. In order for large scale investments to be made within the country, there is a need for foreign participants to be attracted to the Nigerian economy and pull their resources, both financial and non-financial into the country (but, not without regulation). However, for these investors to have confidence to make investments in the Nigerian economy, there has to be a high degree of economic stability in the country. This can be supported by enacting and implementing policies that can enhance the quality of interest rates spread and financial development within the country. The policy implication here involves enhancing financial development through sound policies and adopting competitive interest rates, could increase the rate of foreign inflow into the economy. In view of this, it is also recommended that government policies should target interest rate competitiveness, financial and economic development as well as sustainability.
Domestic Borrowing and the Nigerian Economy: A Bayesian VAR Analysis
Authors: Alenoghena Raymond Osi , Aghughu Adolphus Arhotomhenla , Odior Ernest Simeon
Published: September 2023

ABSTRACT: The Nigerian government has borrowed for more than three decades to fund the growing fiscal deficit based on a weak tax revenue base. After the repayment of the country's foreign loans in 2006, the borrowing structure has been dominated by domestic loans. Between 2006 and 2020, domestic borrowing has grown by more than 800 per cent. This study examines the effect of domestic borrowing on Nigeria's macroeconomic variables from 1975 to 1980. The variables examined against the effect of domestic borrowing include economic growth, financial development (broad money supply and credit to private sector), external borrowing, interest rate, inflation, industrial production, private investment, trade openness and population growth rate. The study utilised the Bayesian Vector Autoregressive (BVAR) model. The BVAR approach gives more realistic estimations than other VAR models as it considers prior information steady states during analysis. The study also adopts the Cholesky impulse response function and variance decomposition approach in the investigation. The study found a long-run equilibrium relationship between domestic borrowing and other macroeconomic variables. Also, domestic borrowing positively and significantly affected economic growth, industrial production and inflation. However, domestic borrowing negatively and significantly affects trade openness. Although the effect of domestic borrowing on the financial development variables (broad money supply and credit to the private sector) is negative, it is insignificant. The Bayesian VAR impulse response simulation demonstrates that the fiscal policy shock from domestic borrowing impacts the macroeconomic variables in line with the estimated regression results. As a follow-up, the variance decomposition results show that the decomposition of the shocks from government domestic borrowing is borne more by external borrowing, broad money supply and interest rate in the order of magnitude. The study recommends a restriction in monetary policy to benchmark and closely checkmate the aggressive spending from domestic borrowing. Also, the Nigerian government should improve investment in infrastructure to enhance private sector productivity and expand taxes revenue base to mitigate the reliance on borrowing as a source of funding for fiscal deficit. Furthermore, the country's productivity must be coordinated by the government to expand the sources of foreign exchange earnings to enhance stability in the country's external sector.
Energy Demand and the Potential Role of Imported Liquefied Natural Gas (LNG) in Bangladesh
Authors: Islam Shahidul , Ghosh Subhadip , Wang Youke
Published: September 2023

ABSTRACT: The rapid economic progress of Bangladesh is associated with a swiftly rising demand and energy consumption. Future economic growth will undoubtedly require a proportionate increase in energy availability within affordable prices. Bangladesh is inherently energy-scarce and heavily dependent on imported energy, primarily fossil fuels. Several approaches and strategies were attempted over time to mitigate the energy shortage. Some of them were reasonably successful, while others failed. In this study, we first examine the historical developments of the energy sector in Bangladesh since its independence and then use three approaches – triple exponential smoothing, vector autoregression, and the Cochrane-Orcutt AR(1) process to forecast the energy demand. Data for this study were taken from various sources, including British Petroleum, International Gas Union, International Energy Agency, Bangladesh Bureau of Statistics, World Bank, Petrobangla, and Energy Information Agency of the United States. As expected, each model predicts an exponential growth of energy demand in Bangladesh. We then explored the possibilities of mitigating such projected energy demand. Various studies show that Bangladesh has some potential for producing energy from renewable sources, i.e., solar, hydro, wind, wave, and others. However, such possibilities are limited, and many are still in their infancy. Although an increase in renewable energy is desirable from an environmental perspective, it alone will not meet Bangladesh's growing energy demand. At least in the short term, Bangladesh must rely on imported fossil energy. Among the fossil energy sources, LNG is by far the cleanest. With the development of technology, liquefaction, transportation, and regasification, LNG production, transportation, and use are becoming less expensive. Progressively more natural gas-producing countries are joining LNG production and export, contributing to the market's competitiveness. Though historically tied to the oil market, LNG markets are becoming more and more independent because of the increasing number of participants from both the demand and supply sides. Given that both its global price and negative impact on the environment are relatively lower than other fossil fuels, imported LNG should be the fuel of choice for Bangladesh. Government policies should focus on both importing LNG and expanding renewable energy resources.
Wage Differentials in the Post Liberalized Labor Market in Paksitan
Authors: Hakro Ahmed Nawaz , Ghulam Yaseen , Jaffry Shabbar , Shah Vyoma
Published: September 2023

ABSTRACT: In this paper, we investigate the wage differentials that exist in the post-liberalized labor market in Pakistan. The increasing wage differential contradicts standard labor theories and models. The literature also confirms the existence of wage differentials across different labor markets both in industrialized and non-industrialized countries. The firms compensate the workers both on their observable and unobservable characteristics. The mincer equation used in its semi-logarithmic decomposed form to derive wage differentials. The weighted adjusted standard deviation technique is used for further decomposition of the level and regional variations in sectoral wage gaps, as suggested by Horrace and Oaxaca. The sectoral heterogeneity, skill characteristics and regional dispersions derived by using the micro labor force data sets spread over thirty years. The results confirm the existence of inter-industry wage differentials. However, the size varies across the regions, levels of education, and types of occupations. A substantial difference in the wage gap observed in firms both in the formal and informal sectors. The financial services firms pay higher than the average national wage followed by firms in utility services, the services sector, and the mining sector. The firms in the agricultural sector pay lower than the average national wage. The dispersion in wages has risen to the magnitude of almost 25 percent over the last three decades. Firms pay higher wages to high-skill workers, while industries requiring jobs with low skills pay lower wages. The wage differentials in various regions are attributable to the persistent and relative backwardness of provinces. The high-skilled occupations in general are likely to have more benefits than those involving low-skilled workers. Individual and household characteristics account for almost 50 percent of variation regardless of the sectoral affiliation. The increase in the minimum wage, with targeted social policies in educational attainment, increased participation of women, and provision of social services in the informal sector may reduce the gap in wage difference.
Income Convergence in Southern Africa: A Nonlinear Time-Varying Framework
Authors: Nzimande Ntokozo Patrick
Published: September 2023

ABSTRACT: Convergence is considered a fundamental economic mechanism and a necessary condition for achieving industrial development and market integration as well as socio-economic cohesion in the Southern African Development (SADC) region. The former is the explicit objective of the SADC, as formulated in its Regional Indicative Strategic Development Plan (RISDP). "[A] key priority under this pillar will be ensuring macroeconomic convergence, increased cooperation, and investment". Despite convergence being a crucial ingredient for the proposed integration in the region, there has been limited research on the subject in Africa, particularly, SADC. To bridge this gap, this study sought to investigate per capita income convergence or lack thereof, in the SADC region over the period 1980 to 2017. To this end, we employed the approach proposed by Phillips and Sul (2008), which not only tests for overall convergence but for the possibility of multiple equilibria as well. Relative to the conventional approaches, this approach is superior in many respects. For instance, this technique requires no prior knowledge about possible convergence clusters, that is, the clusters are endogenously determined. Moreover, it imposes no restraints regarding trend stationarity or stochastic non-stationarity. Consequently, our findings are immune from the inefficiencies linked to unit roots or cointegration tests. The findings of the study suggested no overall convergence in the SADC region, but evidence supporting the existence of five convergence clubs, with each cluster converging to its steady-state equilibrium, and one divergent country, Angola. The first club consisted of only the high-income countries in the region, Seychelles, and Mauritius. The second convergence club had two members as well, South Africa and Botswana, whereas the third club consisted of the Kingdom of Eswatini and Namibia. In the fourth club, the identified members are Comoros, which is not included in the previous study because it was recently admitted into the bloc, Lesotho, Malawi, Mozambique, Tanzania, Zambia, and Zimbabwe, while in the fifth club, the members are the Democratic Republic of Congo and Madagascar. The findings of this study have in-depth implications for the development policies in the SADC region. These findings suggest that the region should consider adopting and implementing policies that would explicitly target low-income countries to promote convergence, and thus, create a conducive environment for the proposed monetary union in the SADC bloc.
Determinants of Youth Financial Inclusion and Their Willingness to Become Entrepreneurs in Tanzania
Authors: Kazungu Khatibu , Njau Frank E.
Published: September 2023

ABSTRACT: Over the last decade or so, Tanzania's economy has registered a significant growth in the rate of financial inclusion. The level of financial exclusion has consistently declined from 55% to 28% between 2009 and 2017 respectively. Moreover, the percentage of the adult population using formal financial services has almost quadrupled between 2009 and 2017. However, available statistics also illustrate that the participation of youth population in the formal banking, insurance, credit and savings products and services remain abysmally low. Furthermore, less than 50 percent of youth borrow from formal financial institutions. Indeed, lack of access to finance is frequently singled out as the major obstacle among youth to engage in entrepreneurial activities. Although much has been done to address financial inclusion, relatively little is known about the determinants of youth financial inclusion as well as the impact of financial inclusion on youth's willingness to engage in entrepreneurship in Tanzania. This study uses World Bank Financial Inclusion Index, (2018) to examine both the determinants of financial inclusion and the effects of financial inclusion on youth willingness to engage in entrepreneurial activities in Tanzania. In doing so, we employ propensity scores matching (PSM) and the treatment effects models. Financial inclusion is measured by using three indicators namely; "formal account", "formal savings" and "formal credit". The results from the logit PSM regression indicate that being employed increases the likelihood of having a current account or a savings account in a formal financial institution amongst the young people. In the case of formal account and formal saving, attaining a secondary education level increases the probability of having a formal account and a formal saving account relative to those with primary education. The estimated results from the Average Treatment Effect, whose computation is built on the propensity scores and the kernel matching algorithm show that having a formal current account, formal saving account and access to formal credit services positively affect the willingness of youths to engage into entrepreneurship. The policy implication is that government policy that enhances expansion of credit to youth remains paramount as a panacea to engage youth in entrepreneurial activities.
Public vs. Private Education and the Labor Market Disparities in Nepal: Evidence From the Blinder-Oaxaca Decomposition
Authors: Kapri Kul Prasad , Ghimire Shankar , Dulal Rajendra
Published: September 2023

ABSTRACT: The debate between private and public education is a widely discussed issue in personal and policy forums globally. In Nepal, private schools have grown significantly due to the perceived advantages associated with them. This paper tests if there are significant differences in labor-market outcomes for individuals educated in private schools compared to those educated in public schools. Research Methodology and Data: We employ nationally representative household survey data from the Nepal Living Standards Survey (NLSS III), conducted by the Central Bureau of Statistics (CBS) Nepal in 2010/11, utilizing the Living Standards Measurement Survey (LMSS) methodology developed by the World Bank. We apply the Blinder-Oaxaca decomposition method to examine the relationship between educational attainment and four distinct measures of labor-market outcomes: labor force participation, employment status, job security, and wage income. Initially, we estimate these outcomes separately for individuals in private education and those in public education. Subsequently, we calculate and analyze whether the disparities in estimated values can be attributed to differences in education. Our findings reveal significant labor-market disparities between individuals participating in private education and those in public education. Those with private education display lower rates of labor force participation and reduced employment rates, suggesting fewer working hours. However, those employed within this group enjoy more secure salaried positions. Furthermore, private education is linked to higher wage incomes, primarily attributable to longer educational periods. The Blinder-Oaxaca decomposition demonstrates that most of these disparities are associated with variations in educational backgrounds. Consequently, the results highlight the role of segregated education in contributing to labor-market inequality, emphasizing the impact of private schools in exacerbating economic disparities in Nepal. The findings underscore the significance of educational attainment in ameliorating disparities between individuals educated in public and private schools. To address these issues, policymakers should concentrate on strategies aimed at increasing the duration of education for public school students, such as providing free, quality higher education. By narrowing the educational gap between private and public institutions, the nation can work towards diminishing wage and job security disparities, fostering a more equitable society. These findings also have relevance for countries grappling with similar socio-economic challenges, initiating essential policy discussions.
Role of Subsidiary Autonomy and Embeddedness in Subsidiary Knowledge Development: Emerging Economy Perspective
Authors: Shukran Khaled , Nazri Mohammad , Mustamil Norizah Binti
Published: September 2023

ABSTRACT: This study examines the factors contributing to developing subsidiary knowledge in Malaysian foreign subsidiaries. Prior research on subsidiaries in multinational corporations has either concentrated on transferring knowledge from headquarters to subsidiaries or vice versa, ignoring the factors associated with subsidiary knowledge development through embedded relationship factors. Although embedded relations are essential for developing knowledge, the direction is most important for developing subsidiary knowledge. The significance of subsidiary knowledge development, subsidiary autonomy, and external and internal embeddedness has been poorly illuminated by prior research. This is because the perception of knowledge development is emphasized from the headquarters' perspective, while the subsidiary functions as a passive recipient. Using the resource-based and network theories, we argue that subsidiary development depends on the subsidiary's autonomy practice and the level of engagement or network relations between external and internal network partners. Our research shows that subsidiary autonomy and external embeddedness are the most significant predictors of subsidiary knowledge development. Internal embeddedness in subsidiary knowledge development is inconsistent with the theoretical assumptions for subsidiary autonomy and external embeddedness. In regression analysis, the survey results of 170 foreign-owned subsidiaries in Malaysia validate our hypotheses. According to the results of this study, subsidiary autonomy and external and internal embeddedness are the most significant predictors of subsidiary knowledge development. This study's findings have implications for subsidiary administrators in developing nations and multinational corporations. While subsidiaries are developing their knowledge, multinationals need to consider how much autonomy to offer them in this process. When subsidiaries are able to make independent decisions, embedded relationships will increase, and knowledge will be more likely to develop. This specific knowledge eventually contributes to the knowledge base of the MNE.
The Variation Between Subjective and Objective Class Positions in South Africa. The Distance Between Perception and Reality
Authors: Kirsten Frederich , Biyase Mduduzi , Botha Ilse , Pretorius Marinda
Published: September 2023

ABSTRACT: The study is an exploratory attempt to assess the relationship between individuals' objective class position and subjective social positions in the South African hierarchy. While objective class dynamics have received much attention in South Africa, less is known about the subjective social position individuals place themselves. The study aims to make use of the International Social Survey Program (ISSP) dataset and assess the relationship between objective and subjective class positions in South Africa. The results show considerable variation between objective and subjective class positions, with a strong middling tendency among all objective class groups in South Africa. The study also shows that this middling tendency has increased in the last decade in South Africa, predominantly due to individuals overestimating their social positions. With a large share of South Africans living close or below the poverty line, there is a clear biasedness of South Africans placing themselves in the middle of society, deviating from their lower objective position. The study further measures the variation between objective and subjective social positions to create a novel class scheme of inflated, deflated, and concordant class perceptions. These biased perceptions are then compared to socio-economic characteristics, showing that gender, race, and education are closely related to bias perceptions in South Africa. Furthermore, the increasing nature of high inequality and social unrest events in South Africa prompts the study also to assess the different social and political attitudes by varying objective and subjective class schemes. The results show that among the subjective class identification, individuals in higher perceived class positions tend to be less angered towards inequality, have lower redistribution preferences, and perceive a weaker conflict between the rich and the poor. These results confirm the impact perceived social positions and biased perceptions could have on social and political attitudes in South Africa. Attitudes that have been considered relevant in voting behavior and social policy formulation models. The results of the paper provides some vital information for policy makers on the dynamics behind subjective class and bias perceptions in South Africa.
Photoacoustic elasto-viscography and optical coherence microscopy for multi-parametric ex vivo brain imaging
Authors: Yang Fen , Ding Wenguo , Fu Xinlei , Chen Wei , Tang Jianbo
Published: September 2023

Optical coherence microscopy (OCM) has shown the importance of imaging ex vivo brain slices at the microscopic level for a better understanding of the disease pathology and mechanism. However, the current OCM-based techniques are mainly limited to providing the tissue’s optical properties, such as the attenuation coefficient, scattering coefficient, and cell architecture. Imaging the tissue’s mechanical properties, including the elasticity and viscosity, in addition to the optical properties, to provide a comprehensive multi-parametric assessment of the sample has remained a challenge. Here, we present an integrated photoacoustic elasto-viscography (PAEV) and OCM imaging system to measure the sample’s optical absorption coefficient, attenuation coefficient, and mechanical properties, including elasticity and viscosity. The obtained mechanical and optical properties were consistent with anatomical features observed in the PAEV and OCM images. The elasticity and viscosity maps showed rich variations of microstructural mechanical properties of mice brain. In the reconstructed elasto-viscogram of brain slices, greater elasticity, and lower viscosity were observed in white matter than in gray matter. With the ability to provide multi-parametric properties of the sample, the PAEV-OCM system holds the potential for a more comprehensive study of brain disease pathology.
Mandatory membership of community-based mutual health insurance in Senegal: A national survey
Authors: Ridde Valéry , Gaye Ibrahima , Ventelou Bruno , Paul Elisabeth , Faye Adama
Published: September 2023

With the low adherence to voluntary mutual health insurance, Senegal’s policymakers have sought to understand the feasibility of compulsory health insurance membership. This study aims to measure the acceptability of mandatory membership in community-based mutual health insurance (CBHI) and to understand its possible administrative modalities. The study consists of a national survey among a representative population sample selected by marginal quotas. The survey was conducted in 2022 over the phone, with a random composition method involving 914 people. The questionnaire measured the socio-economic characteristics of households, their level of acceptability concerning voluntary and compulsory membership, and their level of confidence in CBHIs and the health system. Respondents preferred voluntary (86%) over mandatory (70%) membership of a CBHI. The gap between voluntary and compulsory membership scores was smaller among women (p = 0.040), people under 35 (p = 0.033), and people with no health coverage (p = 0.011). Voluntary or compulsory membership was correlated (p = 0.000) to trust in current CBHIs and health systems. Lack of trust in the CBHI management has been more disadvantageous for acceptance of the mandatory than the voluntary membership. No particular preference emerged as the preferred administrative channel (e.g. death certificate, identity card, etc.) to enforce the mandatory option. The results confirmed the well-known challenges of building universal health coverage based on CBHIs—a poorly appreciated model whose low performance reduces the acceptability of populations to adhere to it, whether voluntary or mandatory. Suppose Senegal persists in its health insurance approach. In that case, it will be essential to strengthen the performance and funding of CBHIs, and to gain population trust to enable a mandatory or more systemic membership.
Analyzing influence of COVID-19 on crypto & financial markets and sentiment analysis using deep ensemble model
Authors: Washington Patrick Bernard , Gali Pradeep , Rustam Furqan , Ashraf Imran
Published: September 2023

COVID-19 affected the world’s economy severely and increased the inflation rate in both developed and developing countries. COVID-19 also affected the financial markets and crypto markets significantly, however, some crypto markets flourished and touched their peak during the pandemic era. This study performs an analysis of the impact of COVID-19 on public opinion and sentiments regarding the financial markets and crypto markets. It conducts sentiment analysis on tweets related to financial markets and crypto markets posted during COVID-19 peak days. Using sentiment analysis, it investigates the people’s sentiments regarding investment in these markets during COVID-19. In addition, damage analysis in terms of market value is also carried out along with the worse time for financial and crypto markets. For analysis, the data is extracted from Twitter using the SNSscraper library. This study proposes a hybrid model called CNN-LSTM (convolutional neural network-long short-term memory model) for sentiment classification. CNN-LSTM outperforms with 0.89, and 0.92 F1 Scores for crypto and financial markets, respectively. Moreover, topic extraction from the tweets is also performed along with the sentiments related to each topic.
Effects of tai chi on postural balance and quality of life among the elderly with gait disorders: A systematic review
Authors: Xu Fan , Soh Kim Geok , Chan Yoke Mun , Bai Xiao Rong , Qi Fengmeng , Deng Nuannuan
Published: September 2023

Background

Tai Chi is good for improving the physical fitness of older adults. But few studies have reported the effects of Tai Chi on the postural balance and quality of life of older adults with gait disorders.

Objective

This review aimed to assess the influence of tai chi on postural stability and quality of life in older adults with abnormal gait.

Method

According to the literature retrieval principles, the works published from the inception date to May 2023 were retrieved, including the following databases: PubMed, Scopus, Web of Science, China National Knowledge Infrastructure, EBSCOhost, and Google Scholar. Subsequently, literature screening and quality assessment were performed.

Results

A total of 16 randomized controlled trials were included in this study, Tai Chi intervention can affect populations with Parkinson’s disease (PD), no exercise, mild cognitive impairment (MCI), chronic stroke, sedentary, fear of falling, or history of falling. Postural instability is associated with balance, gait, the Unified Parkinson’s Disease Rating Scale Motor Subscale 3 (UPDRS III), mobility, lower body strength, and falls. Only two articles looked at quality of life. The Yang style is the most commonly used in the intervention. Nonetheless, most studies were performed on female participants, hence, more research on older male populations is needed.

Conclusion

Tai Chi intervention benefits postural balance in patients with gait disorders. 12 weeks is the most common intervention period for patients with gait disorders. The frequency of intervention is seven articles twice a week, and the intervention time is about 60 minutes. The Tai Chi intervention methods in this study involve Yang Style, Sun Style, Taoist Tai Chi, and Health Qigong Tai Chi, but the Yang Style Tai Chi intervention is the most widely used.
Failure characteristics of rocks with non-persistent joints under local load
Authors: Cheng Hui , Zhao Hongbao
Published: September 2023

Jointed rocks under local load are ubiquitous in civil engineering. The instability and failure of jointed rocks are fatal to engineering safety. This paper numerically investigated the effects of loading area and joint angle on the strength dividing points, energy evolution, and crack distribution characteristics of non-persistent jointed rocks. The results demonstrated that the closer the absolute value of joint angle to 45° and the smaller the loading area, the lower the strength dividing points of rocks. The curves of rock joint angle versus total energy at peak and of elastic energy versus amplitude of post-peak abrupt energy change render a W-shape distribution. Meanwhile, compared with joint angle, loading area has more influence on rock energy input. The larger the loading area, the higher the crack fractal dimension, the crack entropy, and the penetration rate. Tensile cracks outnumber shear cracks when jointed rocks are damaged, and shear cracks increases significantly at the post-peak stage.
Synergistic combination of doxorubicin with hydralazine, and disulfiram against MCF-7 breast cancer cell line
Authors: Lafi Zainab , Alshaer Walhan , Gharaibeh Lobna , Alqudah Dana A. , AlQuaissi Baidaa , Bashaireh Banan , Ibrahim Abed Alqader
Published: September 2023

Disulfiram and hydralazine have recently been reported to have anti-cancer action, and repositioned to be used as adjuvant in cancer therapy. Chemotherapy combined with other medications, such as those that affect the immune system or epigenetic cell profile, can overcome resistance with fewer adverse effects compared to chemotherapy alone. In the present study, a combination of doxorubicin (DOX) with hydrazine (Hyd) and disulfiram (Dis), as a triple treatment, was evaluated against wild-type and DOX-resistant MCF-7 breast cancer cell line. Both wild-type MCF-7 cell line (MCF-7_WT) and DOX-resistant MCF-7 cell line (MCF-7_DoxR) were treated with different combination ratios of DOX, Dis, and Hyd followed by measuring the cell viability using the MTT assay. Synergism was determined using a combination index, isobologram analysis, and dose-reducing index. The anti-proliferation activity and mechanism of the triple combination were investigated by apoptosis analysis. The results showed a reduction in the IC50 values of DOX in MCF-7_WT cells (from 0.24 μM to 0.012 μM) and MCF-7_DoxR cells (from 1.13 μM to 0.44 μM) when treated with Dis (0.03μM), and Hyd (20μM) combination. Moreover, The triple combination DOX/Hyd/Dis induced significant apoptosis in both MCF-7_WT and MCF-7_DoxR cells compared to DOX alone. The triple combination of DOX, Dis, and Hyd showed a synergistic drugs combination to decrease the DOX dose needed to kill both MCF-7_WT and MCF-7_DoxR cancer cells and enhanced chemosensitivity to DOX.
Demographic characteristics associated with West Nile virus neuroinvasive disease – A retrospective study on the wider European area 2006–2021
Authors: Riccetti Nicola , Ferraccioli Federico , Fasano Augusto , Stilianakis Nikolaos I.
Published: September 2023

Background

With a case-fatality-risk ranging from 3.0 to >20.0% and life-long sequelae, West Nile neuroinvasive disease (WNND) is the most dangerous outcome of West Nile virus (WNV) infection in humans. As no specific prophylaxis nor therapy is available for these infections, focus is on preventive strategies. We aimed to find variables associated with WNND diagnosis, hospitalisation or death, to identify high-risk sub-groups of the population, on whom to concentrate these strategies.

Methods

We used data from The European Surveillance System–TESSy, provided by National Public Health Authorities, and released by the European Centre for Disease Prevention and Control (ECDC). In two Firth-penalised logistic regression models, we considered age, sex, clinical criteria, epidemiological link to other cases (epi-link), calendar year, and season as potential associated variables. In one model we considered also the rural/urban classification of the place of infection (RUC), while in the other the specific reporting country.

Findings

Among confirmed West Nile Virus cases, 2,916 WNND cases were registered, of which 2,081 (71.4%), and 383 (13.1%) resulted in the hospitalisation and death of the patient, respectively. Calendar year, RUC/country, age, sex, clinical criteria, and epi-link were associated with WNND diagnosis. Hospitalisation was associated with calendar year and RUC/country; whereas death was associated with age, sex and country.

Interpretation

Our results support previous findings on WNND associated variables (most notably age and sex); while by observing the whole population of WNND cases in the considered area and period, they also allow for stronger generalizations, conversely to the majority of previous studies, which used sample populations.
NOP2/Sun RNA methyltransferase 2 is a potential pan-cancer prognostic biomarker and is related to immunity
Authors: Zheng Lemei , Li Mengna , Wei Jianxia , Chen Shipeng , Xue Changning , Duan Yumei , Tang Faqing , Li Guiyuan , Xiong Wei , She Kelin , Deng Hongyu , Zhou Ming
Published: September 2023

Background

NOP2/Sun RNA methyltransferase 2 (NSUN2), an important methyltransferase of m5C, has been poorly studied in cancers, and the relationship between NSUN2 and immunity remains largely unclear. Therefore, the purpose of this study was to explore the expression and prognostic value of NSUN2 and the role of NSUN2 in immunity in cancers.

Methods

The TIMER, CPTAC and other databases were used to analyze the expression of NSUN2, its correlation with clinical stage and its prognostic value across cancers. Moreover, the TISIDB, TIMER2.0 and Sangerbox platform were used to depict the relationships between NSUN2 and immune molecular subtypes, tumor-infiltrating lymphocytes (TILs), immune checkpoints (ICPs) and immunoregulatory genes. Furthermore, the NSUN2-interacting proteins and related genes as well as the coexpression networks of NSUN2 in LIHC, LUAD and HNSC were explored with the STRING, DAVID, GEPIA2 and LinkedOmics databases. Finally, the subcellular location and function of NSUN2 in HepG2, A549 and 5-8F cells were investigated by performing immunofluorescence, CCK-8 and wound healing assays.

Results

Overall, NSUN2 was highly expressed and related to a poor prognosis in most types of cancers and was also significantly associated with immune molecular subtypes in some cancer types. Furthermore, NSUN2 was significantly associated with the levels of ICPs and immunoregulatory genes. In addition, NSUN2 was found to be involved in a series of immune-related biological processes, such as the humoral immune response in LIHC and LUAD and T-cell activation and B-cell activation in HNSC. Immunofluorescence and CCK-8 assays also confirmed that NSUN2 was widely expressed in the nucleus and cytoplasm, and overexpression of NSUN2 promoted the proliferation and migration of HepG2, A549 and 5-8F cells. NSUN2 was also confirmed to positively regulate the expression of PD-L1.

Conclusion

NSUN2 serves as a pan-cancer prognostic biomarker and is correlated with the immune infiltration of tumors.
3D cell-culture strategy for screening novel agents in Fanconi Anemia chemoprevention
Authors: Unger Gretchen , Arij Sanjana , Brown Mary E , Wuetz Beverly , Trembley Janeen , Ondrey Frank
Published: September 2023

Fanconi anemia (FA) patients have DNA repair mutations predisposing them to oral cancers so treatment with non-DNA damaging agents is highly desired. As cancer experimental therapeutics advance towards study paradigms that more carefully mimic physiology, e.g. organoids and spheroids. Presently, we are using a 3D cell culture method emphasizing layers of extracellular matrix (ECM) as FA premalignant lesions retain epithelial architecture. We conducted 3D screening studies using 2 layered geometries: 1) nanofibers coated with 1 ng/mL 2:1 Collagen III/IV (C3C4) then 100 pg/mL 2.75:1 Tenascin C/Fibronectin (TNFN) and 2) polystyrene layered with 50 ug/mL C3C4 then 3.5 ug/mL TNFN. We developed these coatings to maximize lipid raft recovery, a drug transport feature lost in 2D culture. The ECM impact on FA cell drug transport was characterized by comparing effective nuclear delivery of a 20nm nanoencapsulated FITC-labeled RNAi compound (s50-TBG-RNAi3UTR), known to require lipid rafts, to the same oligo formulated with Dotap in a FA HNSCC cell line (FA1). Using confocal microscopy and IMARS software to segment delivery at maximal nuclear intensity into nuclear or endolysosomal compartments, we found, for FA1 cells on ECM, nuclear oligo signal colocalization with nuclear compartment ± coefficient of variation was 62 ± 2.2% for the capsule vs 9.8 ± 8.5% for Dotap oligo. On glass, nuclear delivery was 10 ± 52% for s50 capsule vs 25 ± 32% for Dotap. Endolysosomal compartment sequestration was respectively 28 ± 12, 62 ± 10, 44 ± 19 and 51 ± 15%. This illustrates a relevant decrease in variation in FA cell biology from ECM addition. Next, we studied metformin (Met) and pioglitazone (Pio)(agents in current oral cancer prevention studies) combined with G2/M blockade inhibitors, MK1775 (Wee1 kinase inhibitor) and GSK461364 (PLK inhibitor) in FA1s. Inhibiting G2/M blockade, already induced by FA-derived DNA damage, could promote inappropriate cell division, mitotic catastrophe (MTOC) and death. In initial 2D FA1 growth studies, increased death was observed with Met plus MK1775. 3D studies, in contrast, showed increased cell death for FA1s treated with Pio plus either MK1775 or s50-TBG-RNAiCK2 (RNAiCK2). Confocal mechanistic studies in cells plated on ECM and treated for 18 hours, indicated Pio + MK1775 had inhibited Survivin and ß-catenin upregulation and FA1 cells did proceed into MOC and death. For Pio (PPARg agonist) + RNAiCK2, RXRa was dephosphorylated at S260, enabling its escape from cytosolic sequestration to bind nuclear PPARg, initiating differentiation. Differentiation was indicated by upregulation of panKeratin and Transglutaminase-3. We conclude combination therapies with high interest agents in FA-associated oral cancer can be performed in 3D culture systems and might confirm drug mechanisms of action, thus augmenting other standard methods of cancer drug evaluation and screening (e.g. cell proliferation and clonogenicity).
Different Urbanization Levels Lead to Divergent Responses of Spring Phenology
Authors: Dang Chaoya , Shao Zhenfeng , Huang Xiao , Cheng Gui , Qian Jiaxin
Published: September 2023

Urban vegetation phenology is important for understanding the relationship between human activities on urban ecosystems and carbon cycle. The relationship between urban and rural vegetation phenology and environmental and meteorological factors were studied across urban-rural gradients.
However, the relationship of intra-urban urbanization intensity (UI) gradients on vegetation at the start of season (SOS) is unclear. Here, we used remote sensing data to quantitatively assess the relationship of vegetation SOS to UI gradients at mid-high latitudes in the northern hemisphere.
The results showed that urban area vegetation SOS widely presented earlier than for rural area vegetation. Across the cities we investigated the extent UI gradient was prevalent as a threshold (33.2% ± 2.3%) of surface temperature to SOS advance enhancement and offset.
At low urbanization enhanced surface temperature on sos advances, while at high urbanization offset surface temperature on SOS advances. Overall, UI demonstrated a nonlinear relationship with sos. The results of this study suggest that there may be thresholds of impact on vegetation SOS in
future global climate and environment change processes, where opposite effects can occur below and above thresholds.