bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kesesuaian Air Sumber untuk Budidaya Udang di Kecamatan Purwodadi, Kabupaten Purworejo
Authors: Setyawan Arief Rahmat , Purnama Setyawan , Sudarmadji Sudarmadji
Published: July 2021

Kecamatan Purwodadi merupakan kawasan yang diarahkan sebagai wilayah pertambakan udang karena ketersediaan areal pesisir yang luas dan sumber air yang memadai. Kesesuaian lokasi merupakan faktor penting pada budidaya udang, karena dapat mempengaruhi kesuksesan dan keberlanjutan suatu tambak. Pengukuran kualitas parameter perairan terhadap komoditas budidaya perlu dilakukan untuk mengetahui tingkat kesesuaiannya terhadap komoditas yang dibudidayakan. Penelitian bertujuan untuk mengetahui kesesuaian air tanah di kawasan pertambakan Kecamatan Purwodadi, Kabupaten Purworejo. Penelitian dilakukan dengan membandingkan nilai kualitas air sumber dengan baku mutu yang ada dengan menggunakan 10 sumur sumber tambak udang. Hasil pengamatan terhadap kualitas air tanah pada sumur sumber tambak di kawasan pertambakan Kecamatan Purwodadi menunjukan dari 10 parameter yang digunakan, terdapat 4 parameter yang tidak sesuai dengan baku mutu air sumber untuk budidaya udang vanname yaitu oksigen  terlarut (6 sumur sumber), chemical oxygen demand (COD) (8 sumur sumber), nitrit (5 sumur sumber), dan amonia (3 sumur sumber). Berdasarkan tingkat kualitas air sumur sumber, mayoritas sumur sumber tidak memenuhi kriteria dengan hanya sumur 5 yang memenuhi baku mutu, dan sumur 3 serta 4 yang paling tidak memenuhi kriteria (4 parameter tidak memenuhi baku mutu). Pemilihan lokasi sumur sumber dan pengecekan kualitas sumur sumber diperlukan untuk mendapatkan air sumber yang memenuhi ambang batas serta penerapan teknologi dalam budidaya perlu dilakukan untuk menjaga kualitas air budidaya.
Peta Biodiversitas Zooplankton di Area Pesisir Utara dan Selatan Madura, Jawa Timur
Authors: Zakiyah Umi , Mulyanto Mulyanto
Published: July 2021

Kelimpahan serta biodiversitas zooplankton sangat tergantung pada keberadaan fitoplankton sebagai makanan utamanya. Fitoplakton berperan penting sebagai produsen primer di perairan. Keberadaan fitoplankton sendiri selain bergantung faktor fisika-kimiawi perairan, juga nutrien seperti  nitrat dan fosfat. Penelitian ini bertujuan untuk memetakan sebaran biodiversitas zooplankton serta faktor yang mempengaruhinya di pesisir utara dan selatan Madura, Jawa Timur. Lokasi pengambilan sampel dilakukan secara purposive di Pantai Pasongsongan, Sumenep dan pantai Pantai Branta Pamekasan di tiga stasiun yang berbeda. Pengukuran parameter kualitas air dilakukan secara in situ dan ex situ, dan analisis biodiversitas zooplankton dilakukan dengan indeks biologi meliputi indeks keanekaragaman, indeks dominansi dan juga dilakukan analisis distribusi spasial menggunakan QGIS Las Palmas 3.10.2 untuk mengetahui peta distribusi kelimpahan nitrat, fosfat, fitoplankton dan zooplankton. Hasil penelitian menunjukkan bahwa kandungan nitrat di pesisir utara Madura berkisar 0,0973 - 0,1124 ppm, sedikit lebih rendah dari pantai selatan Pamekasan yang berkisara antara 0,008 - 0,11 ppm. Konsentrasi fosfat berkisar antara 0,0388 - 0,0685 ppm di pantai utara dan 0,05 - 0,06 ppm di pantai selatan. Selama penelitian ditemukan zooplankton sebanyak 19 genera dari 7 filum. Sub kelas yang paling banyak ditemukan adalah Copepoda dari filum Arthopoda. Densitas zooplankton berkisar antara 48,408 - 57,325 Ind./L di pesisir utara Madura dan antara 210,191 - 314,650 Ind./L di pesisir selatan. Sebaran tertinggi zooplankton didapatkan pada stasiun satu di setiap lokasi sampling baik di pesisir utara maupun selatan Madura. Hal ini sesuai dengan data densitas fitoplankton yang juga menunjukkan nilai yg tinggi di stasiun tersebut. Nilai indeks keanekaragaman yang diperoleh di pesisir selatan sedikit lebih tinggi yaitu berkisar antara 1,6 - 2,05, dibandingkan nilai di pesisir utara berkisar antara  1,2 - 1,4 meskipun nilai tersebut termasuk kedalam kategori keanekaragaman sedang.  Hal ini diikuti nilai indeks dominansi berkisar antara 0,17 - 0,39 di pesisir utara  dan selatan berkisar antara 0,3 – 0,4 atau dengan kata lain tidak ada genus zooplankton yang mendominasi. Berdasarkan peta sebaran biodiversitas zooplankton disimpulkan bahwa pesisir selatan memiliki biodiversitas zooplankton yang relatif lebih rendah dengan dominansi relatif lebih tinggi dibandingan dengan pesisir utara Madura yang memiliki biodiversitas lebih tinggi dan dominansi spesies yangg lebih  rendah.
Peningkatan Ketahanan Benih Ikan Nila Salin (Oreochromis niloticus) terhadap Penyakit Streptococcosis Melalui Vaksinasi Induk
Authors: Rahmi Rahmi , Nisaa Khairun , Akmal Akmal , Mardiana Mardiana , Chadijah Andi , Salam Nur Insana
Published: July 2021

Penelitian bertujuan untuk menghasilkan benih ikan nila salin yang tahan terhadap penyakit streptococcocis melalui vaksinasi induk. Vaksin yang digunakan dalam penelitian ini adalah bakteri Streptococcus sp. yang dilemahkan dengan formalin 3% (v/v). Penelitian ini dilaksanakan pada Juni-September.  Vaksin diinjeksikan pada indukan TKG 2 sebanyak 0,4 mL/kg (konsentrasi 1x109 CFU/mL). Penelitian terdiri dari tiga perlakuan yaitu indukan diinjeksi dengan phosphate buffered saline (PBS) (K), indukan diinjeksi vaksin satu kali (A1), dan indukan diinjeksi vaksin sebanyak dua kali dengan selang waktu dua minggu (A2). Benih yang dihasilkan dari masing-masing perlakuan, diuji tantang melalui perendaman dengan bakteri Streptococcus sp. 107 CFU/mL selama 30 menit pada 10, 15, dan 20 hari setelah penetasan. Parameter yang diamati adalah penetasan telur, aktivitas lisozim, kematian benih setelah uji tantang, dan persentase kelangsungan hidup relatif (RPS) benih. Hasil penelitian menunjukkan bahwa daya tetas telur pada perlakuan A2 (92,21%) secara nyata lebih tinggi (P<0,05) dibandingkan perlakuan induk lainnya, serta aktivitas lisozim (99,47-197,89 U/mL) sampai dengan hari ke-20. Angka kematian pada perlakuan A2 (2,34-45,21%) secara signifikan lebih rendah (P<0,05) dibandingkan perlakuan lain sampai hari ke-20. Nilai RPS indukan A2 tidak berbeda nyata (P>0,05) dengan perlakuan benih dari indukan A1 pada hari ke sepuluh tetapi lebih tinggi pada hari ke 20.
Kajian Molekuler Ikan Oreochromis spp. dari Perairan Daratan Merauke-Papua, Berdasarkan DNA Mitokondria Fragmen Gen Sitokrom Oksidase Subunit I
Authors: Saleky Dandi , Sianturi Reny , Dailami Muhammad , Kusuma Aradea Bujana
Published: July 2021

Pemanfaatan perikanan secara lestari sangat diperlukan agar sumberdaya perikanan yang ada saat ini bisa terus dimanfaatkan dan juga dalam rangka pemulihan stok perikanan yang telah rusak. Ikan nila (Oreochromis niloticus) dan ikan mujair (Oreochromis mossambicus) secara luas telah dikenal sebagai salah satu spesies ikan air tawar yang penting dalam perikanan budidaya. Penelitian ini dilakukan dengan tujuan identifikasi spesies ikan Oreochromis spp. dari perairan daratan Merauke dengan menggunakan marka gen COI. Amplifikasi DNA dengan gen COI menghasilkan panjang sekuen DNA 656 bp dengan hasil identifikasi adalah O. niloticus dan O. mussambicus dengan tingkat kemiripan 100 % pada masing-masing spesies. Berdasarkan analisis filogenetik dan jarak genetik, sekuen DNA yang dianalisis membentuk clade sesuai dengn hasil indentfikasi dengan jarak genetik 0,000 - 0,002 pada ikan nila dan 0,000 pada ikan mujair. Analisis keragaman genetik ditemukan hanya 1 haplotype dari kedua jenis ikan tersebut. DNA barcode dan filogenetik dapat digunakan dalam mengidentifikasi spesies dalam pengelolaan dan konservasi.
Evaluierung des COMET-Programms
Authors:   Technopolis Group - Austria, Warta Katharina , Dudenbostel Tobias , Calatrava Moreno María del Carmen , Guadagno Francesca , Zingerle Simon , Skok Sandra , Grill Harald
Published: July 2021

Technopolis wurde im Mai 2020 vom Bundesministerium für Klimaschutz, Umwelt, Energie, Mobilität, Innovation und Technologie (BMK) und dem Bundesministerium für Digitalisierung und Wirtschaftsstandort (BMDW) mit der Evaluierung des COMET-Programms beauftragt. Die vorliegende Evaluierung bezieht sich auf die 25 aktuell existierenden Zentren. Der Fokus der Evaluierung liegt auf der Charakterisierung der COMET-Zentren und auf dem Monitoring- und Kennzahlensystem von COMET. Im Jahr der Corona-Pandemie wurden die Methoden angepasst, Interviews mit Stakeholdern und den Zentren wurden meist per Videocalls oder telefonisch geführt, geplante on-site Visits sowie internationale Workshops konnten nicht durchgeführt werden. Zentrale Quellen der Evaluierung sind eine Befragung der Zentren und der Unternehmens- und Wissenschaftspartner sowie die Datenbasis der FFG, die wir durch diverse Harmonisierungsschritte für neuwertige Auswertungen nutzbar machten. Dies umfasst insbesondere einen historischen Rückblick sowie eine Cluster- und Netzwerkanalyse. Die Auswartungen sind in zwei Dashboards angelegt, das Dashboard zur COMET-Befragung ist anonymisiert und daher öffentlich zugänglich.
Epithelial sodium channel (ENaC) in GtoPdb v.2021.2
Authors: Hanukoglu Israel
Published: July 2021

The epithelial sodium channels (ENaC) are located on the apical membrane of epithelial cells in the kidney tubules, lung, respiratory tract, male and female reproductive tracts, sweat and salivary glands, placenta, colon, and some other organs [9, 13, 22, 21, 42]. In these epithelia, Na+ ions flow from the extracellular fluid into the cytoplasm of epithelial cells via ENaC. The Na+ ions are then pumped out of the cytoplasm into the interstitial fluid by the Na+/K+ ATPase located on the basolateral membrane [36]. As Na+ is one of the major electrolytes in the extracellular fluid (ECF), osmolarity change initiated by the Na+ flow is accompanied by a flow of water accompanying Na+ ions [6]. Thus, ENaC has a central role in regulating ECF volume and blood pressure, primarily via its function in the kidney [37]. The expression of ENaC subunits, hence its activity, is regulated by the renin-angiotensin-aldosterone system, and other factors involved in electrolyte homeostasis [37, 30]. In the respiratory tract and female reproductive tract, large segments of the epithelia are composed of multi-ciliated cells. In these cells, ENaC is located along the entire length of the cilia that cover the cell surface [15]. Cilial location greatly increases ENaC density per cell surface and allows ENaC to serve as a sensitive regulator of osmolarity of the periciliary fluid throughout the whole depth of the fluid bathing the cilia [15]. In contrast to ENaC, CFTR (ion transporter defective in cystic fibrosis) is located on non-cilial cell-surface [15]. In the vas deferens segment of the male reproductive tract, the luminal surface is covered by microvilli and stereocilia projections with backbones composed of actin filament bundles [42]. In these cells, both ENaC and the water channel aquaporin AQP9 are localized on these projections and also in the basal and smooth muscle layers [42]. Thus, ENaC function is also essential for the clearance of respiratory airways, transport of germ cells, fertilization, implantation, and cell migration [15, 22].
Formylpeptide receptors in GtoPdb v.2021.2
Authors: Bäck Magnus , Boulay François , Chiang Nan , Dahlén Sven-Erik , Dahlgren Claes , Drazen Jeffrey , Evans Jilly F. , Gerard Craig , Murphy Philip M. , Parmentier Marc , Quinn Mark , Rovati G. Enrico , Serhan Charles N. , Shimizu Takao , Wang Ji Ming , Ye Richard D. , Yokomizo Takehiko
Published: July 2021

The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [196]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLP) and endogenous ligands such as lipoxin A4 (LXA4), 15-epi-lipoxin A4, annexin I , cathepsin G, amyloid β42, serum amyloid A and spinorphin, derived from β-haemoglobin. FPR1 also serves as a plague receptor for selective destruction of human immune cells by Y. pestis [135]. The FPR1/2 agonists 'compound 17b' and 'compound 43' have shown cardiac protective functions [149, 64].
Cytochrome P450 in GtoPdb v.2021.2
Authors: Burns Kathryn , Helsby Nuala Ann
Published: July 2021

The cytochrome P450 enzyme superfamily (CYP), E.C. 1.14.-.-, are haem-containing monooxygenases with a vast range of both endogenous and exogenous substrates. These include sterols, fatty acids, eicosanoids, fat-soluble vitamins, hormones, pesticides and carcinogens as well as drugs. Listed below are the human enzymes, their relationship with rodent CYP enzyme activities is obscure in that the species orthologue may not metabolise the same substrates. Some of the CYP enzymes located in the liver are particularly important for drug metabolism, both hepatic and extrahepatic CYP enzymes also contribute to patho/physiological processes. Genetic variation of CYP isoforms is widespread and likely underlies a proportion of individual variation in drug disposition. The superfamily has the root symbol CYP, followed by a number to indicate the family, a capital letter for the subfamily with a numeral for the individual enzyme. Some CYP are able to metabolise multiple substrates, others are oligo- or mono- specific.
Galanin receptors in GtoPdb v.2021.2
Authors: Gundlach Andrew L. , Ryan Philip J.
Published: July 2021

Galanin receptors (provisional nomenclature as recommended by NC-IUPHAR [57]) are activated by the endogenous peptides galanin and galanin-like peptide. Human galanin is a 30 amino-acid non-amidated peptide [52]; in other species, it is 29 amino acids long and C-terminally amidated. Amino acids 1-14 of galanin are highly conserved in mammals, birds, reptiles, amphibia and fish. Shorter peptide species (e.g. human galanin-1-19 [21] and porcine galanin-5–29 [170]) and N-terminally extended forms (e.g. N-terminally seven and nine residue elongated forms of porcine galanin [22, 170]) have been reported. More recently, the newly-identified peptide, spexin (SPX), has been reported to activate human GAL2 and GAL3 (but not GAL1) receptors in heterologous expression systems; and to alter GAL2/3 receptor-related behaviours in animals [89].
Two P domain potassium channels in GtoPdb v.2021.2
Authors: Baggetta Austin M. , Bayliss Douglas A. , Czirják Gábor , Enyedi Péter , Goldstein Steve A.N. , Lesage Florian , Minor, Jr. Daniel L. , Plant Leigh D. , Sepúlveda Francisco , Winn Brenda T.
Published: July 2021

The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-forming α-subunit contains two pore loop (P) domains and two subunits assemble to form one ion conduction pathway lined by four P domains. It is important to note that single channels do not have two pores but that each subunit has two P domains in its primary sequence; hence the name two P domain, or K2P channels (and not two-pore channels). Some of the K2P subunits can form heterodimers across subfamilies (e.g. K2P3.1 with K2P9.1). The nomenclature of 4TM K channels in the literature is still a mixture of IUPHAR and common names. The suggested division into subfamilies, described in the More detailed introduction, is based on similarities in both structural and functional properties within subfamilies and this explains the "common abbreviation" nomenclature in the tables below.
Voltage-gated calcium channels in GtoPdb v.2021.2
Authors: Catterall William A. , Perez-Reyes Edward , Snutch Terrance P. , Striessnig Jörg
Published: July 2021

Calcium (Ca2+) channels are voltage-gated ion channels present in the membrane of most excitable cells. The nomenclature for Ca2+channels was proposed by [127] and approved by the NC-IUPHAR Subcommittee on Ca2+ channels [70]. Most Ca2+ channels form hetero-oligomeric complexes. The α1 subunit is pore-forming and provides the binding site(s) for practically all agonists and antagonists. The 10 cloned α1-subunits can be grouped into three families: (1) the high-voltage activated dihydropyridine-sensitive (L-type, CaV1.x) channels; (2) the high- to moderate-voltage activated dihydropyridine-insensitive (CaV2.x) channels and (3) the low-voltage-activated (T-type, CaV3.x) channels. Each α1 subunit has four homologous repeats (I-IV), each repeat having six transmembrane domains and a pore-forming region between transmembrane domains S5 and S6. Voltage-dependent gating is driven by the membrane spanning S4 segment, which contains highly conserved positive charges that respond to changes in membrane potential. All of the α1-subunit genes give rise to alternatively spliced products. At least for high-voltage activated channels, it is likely that native channels comprise co-assemblies of α1, β and α2-δ subunits. The γ subunits have not been proven to associate with channels other than the α1s skeletal muscle Cav1.1 channel. The α2-δ1 and α2-δ2 subunits bind gabapentin and pregabalin.
Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2
Authors: Annett Stephanie , Robson Tracy
Published: July 2021

Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [59], and family members have been targetted for immunosuppressant effects.
Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2
Authors: Ahlers-Dannen Katelin E. , Alqinyah Mohammed , Bodle Christopher , Bou Dagher Josephine , Chakravarti Bandana , Choudhuri Shreoshi P. , Druey Kirk M. , Fisher Rory A. , Gerber Kyle J. , Hepler John R. , Hooks Shelley B. , Kantheti Havish S. , Karaj Behirda , Layeghi-Ghalehsoukhteh Somayeh , Lee Jae-Kyung , Luo Zili , Martemyanov Kirill , Mascarenhas Luke D. , McNabb Harrison J. , Montañez-Miranda Carolina , Ogujiofor Osita W. , Phan Thi Nhu Hoa , Roman David L. , Shaw Vincent , Sjögren Benita , Spicer Mackenzie M. , Squires Katherine E. , Sutton Laurie , Wendimu Menbere , Wilkie Thomas M. , Xie Keqiang , Zhang Qian , Zolghadri Yalda
Published: July 2021

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins stabilize the transition state for GTP hydrolysis on Gα and thus induce a conformational change in the Gα subunit that accelerates GTP hydrolysis, thereby effectively turning off signaling cascades mediated by GPCRs. This GTPase accelerating protein (GAP) activity is the canonical mechanism of action for RGS proteins, although many also possess additional functions and domains. RGS proteins are divided into four families, R4, R7, R12 and RZ based on sequence homology, domain structure as well as specificity towards Gα subunits. For reviews on RGS proteins and their potential as therapeutic targets, see e.g. [225, 529, 578, 583, 584, 742, 753, 444, 10].
Life Treasure Blood Portal by Using Java
Authors: Khan Danish
Published: July 2021

A blood bank is a place where we grater blood as a result of blood donation, stored and preserved for later use in blood transfusion no doubt. There are many online web-based blood bank management systems to satisfy the requirement of donor and receivers. There we are going to modify the existing System as this paper includes the key features, merits and demerits in existing web-based blood bank. This study shows the comparison between various existing systems and provides more idea to improve the existing system In this paper, we present s “Life Treasure Blood Portal” that is a based-on java. To develop this system, we are using different kind of technology, like html, Ajax, JSP, CSS, bootstrap, Servlet , Java-Script, JDBC. This system will monitor the record of blood donation in real-time and given the analytical report like which city has more number of blood donor, which any has more number of blood receiver which blood group is more donated etc. So, there I am going to introduce this system and in at the end I will conclude.
Research and Implementation of Mobile Advertising System Based on Location Service
Authors: Karale Prof. Ankita
Published: July 2021

A Location Based Mobile Advertising is an information and entertainment service, accessible through Smartphones through the ability to use the location of mobile phones. Marketers should be allowed to publish and classify ads according to the consumer interests. If information is not available voluntarily in the short term, Then the consumers Interest may be lost in order to purchase the products. They need to find more information and location without having to make a lot of effort. The Location-Based Mobile Advertising service allows customers to receive advertiser details such as their Location, discounts, and product descriptions. This service also provides information about the nearest tourist destinations according to their location.
Router1x3 Protocol Design Implementation and Verification with Virtual Cut through Mechanism for Network on Chip (NoC)
Authors: . Shambhavi
Published: July 2021

Hundreds of processors and memory cores are implemented on a single substrate called the System on Chip (SoC). The SoC with bus-based architecture has restrictions on the processing speed of the system and as the design becomes complex and the issue of scalability arises. Hence NoC is designed to enhance the scalability, data reliability, and processing speed with low power consumption by decoupling communication from computations [1]. Using NoC the IP cores of SoC are connected through on-chip routers and send data to each other through packet switching. The router is a processing chip that decides the right path for data transmission, hence the efficient design of the router is essential to enhance the performance and throughput of the system [2]. To reduces latency through the switch, the Virtual cut-through mechanism is a packet switching technique, in which the switch starts forwarding a packet as soon as the destination address is processed by header. Hence the present work focuses on a router input-output protocol design with the Virtual Cut-through mechanism for closed-loop communication. Router 1x3 has a single input port and three output ports. The architecture of Router 1x3 with sub-modules such as FIFO, FSM, Synchronizer, and Register is designed analyzed and verified using Verilog, System Verilog language, and Universal Verification Methodology(UVM). And it is also implemented on Xilinx 14.5 IDE with Spartan-6- XC6SLX45 FPGA.
Evolution and Characteristics of Bag-Valve-Mask Ventilation During Pandemic: A Review of the Literature
Authors: Bhoyar Ankit D.
Published: July 2021

Mass casualty incidents such as those that are being experienced during the novel coronavirus disease (COVID-19) pandemic can overwhelm local healthcare systems, where the number of casualties exceeds local resources and capabilities in a short period of time. The introduction of patients with worsening lung function as a result of COVID-19 has strained traditional ventilator supplies. To bridge the gap during ventilator shortages and to help clinicians triage patients, manual resuscitator devices can be used to deliver respirations to a patient requiring breathing support. For patients who require ventilatory support, manual ventilation is a vital procedure. It has to be performed by experienced healthcare providers that are regularly trained for the use of bag-valve-mask (BVM) in emergency situations. We will present, a historical view on manual ventilation’s evolution throughout the last decades. Artificial ventilation has developed progressively and research is still going on to improve the actual devices used. Throughout the past years, a brand-new generation of ventilators was developed, but little was done for manual ventilation. Manual ventilation through BVM can be replaced by automatic ventilation which illustrates that the Tidal Volume vs. Time graph of the automated system is similar to the graph produced by manual operation of the BVM and to the graph produced by a human subject. The use of an automatic manually operated device may improve ventilation efficiency and decrease the risk of pulmonary overdistention, while decreasing the ventilation rate.
Arduino Based Home Automation using TV Remote
Authors: Mounika K
Published: July 2021

House control and monitoring system using Bluetooth and infrared. In Bluetooth with android smart phone connectivity and for accessing and controlling devices and appliances remotely using Android based Smart phone applications. In IR-based house Appliances Control System is a control system using which the user can control different home appliances with a remote controller. The future system does not require a dedicated server PC with respect to similar systems and offers a novel communication protocol to monitor and control the house environment with more than just the switching functionality. House automation using Bluetooth is a residence incorporating a communications network that connects the electric home equipment and offerings letting them be remotely controlled, monitored or accessed. house automation System includes different approaches to achieve multiple objectives range from enhancing consolation in day by day existence to permitting a greater unbiased existence for aged and handicapped people. The system design is based on Arduino Microcontroller using C/C++, language software, Bluetooth and infrared (IR) which is used in different monitoring and control processes. This project the combination hardware and software implementation of a multiple form control system for house automation, combines both hardware and software technologies. The system results show that it can be classified as comfortable, secure, private, economic and safe house automation in addition to its great flexibility and Reliability.
In Silico Prediction and Evaluation of the Selected Microbial Strain with Prebiotic Properties
Authors: Shree Aditya
Published: July 2021

Probiotics are useful bacteria which helps the human body when taken in adequate amount to improve the overall health as well as prevention of various illnesses. Probiotics can be used in treating many diseases ranging from respiratory tract infections to gastrointestinal diseases. Lactobacilli species are omnipresent in the environment and they also play an important role in food and other industries. Besides the environment they are also part of intestinal, oral and vaginal microbiome. In this study we have considered the Lactobacillus casei BL23 strain and compared with the other majorly commercialized strains and found that they are almost similar to the former strain. The genome of the BL23 was sequenced using a combination of pyro-sequencing and short gun sequencing. The CRISPR array is identified by using the CRISPR finder tool. The present study analysed the genome completely for the presence of antibiotic resistance that acquired as a defence mechanism and tried to forward the study and apply it in the food safety. In-silico analysis of Lactobacillus casei BL23 genome sequence resulted in CRISPR as immune or defence mechanism against the foreign elements. There is only one array and 21 spacers. The genome sequence data clearly showed that there are no plasmids present in this strain. The result obtained suggested that Lactobacillus casei BL23 can be utilised in food industry as it facilitate its application as a probiotic or starter culture in food industries and considered to be save as it is free of virulence determinants.
Teknik pemodelan untuk mengurangi perilaku mengganggu pada anak
Authors: Andina Noor Latifah
Published: July 2021

The client is a 7 year old boy who complains of disturbing his friends and relatives at home. The results of the assessment through interviews, observations, psychological tests (CPM) and the Destructive Behavior Disorder Rating Scale (DBD) found that clients have problems with disruptive behavior, with a background problem in learning the wrong way from their environment. The goal of the intervention is to reduce the client’s disruptive behavior. The intervention given is Symbolic Modeling Technique using video and role play. The results of the intervention show a decrease in the client’s disruptive behavior and are used as guidelines or new, more positive patterns.
Reality Therapy untuk meningkatkan penyesuaian diri remaja dengan gangguan major depressive disorder
Authors: Ady Intan Novantin Citra
Published: July 2021

The subject is an 18-year-old prisoner who was diagnosed with Major Depressive Disorder. The assessments used include interviews, observations, WARTEGG tests, SSCT tests, and Graphic tests. The results of the assessment show that the subject is a person who is difﬁcult to adjust to a new environment, cannot accept his current life and wants to commit suicide. The intervention given was Reality Therapy which consisted of seven sessions. The purpose of this intervention is to help the subject to realize his own needs and make the right decisions for him. The results of the intervention showed that the subject became more accepting of his life in prison and could more calmly carry out activities in prison.
Analisis pendapatan usaha industri kerupuk amplang di Kecamatan Tungkal Ilir Kabupaten Tanjung Jabung Barat
Authors: Alfarisyi Salman , Hodijah Siti , Nurhayani Nurhayani
Published: July 2021

This study aims to analyze the socio-economic characteristics of entrepreneurs and the amplang cracker industry business, the magnitude of the amplang cracker industry business income, and the factors that affect the income of the amplang cracker industry entrepreneur in Tungkal Ilir District, Tanjung Jabung Barat Regency. The research method used in this study is a survey method, with descriptive analysis and quantitative analysis. Based on the results of data processing using the OLS method in multiple linear regression equations, the results obtained are: The socio-economic characteristics of all amplang cracker industry entrepreneurs are 83.33 percent with a high school graduate/equivalent. The average number of dependents and the number of workers is 4 people. The average net income of Rp. 15,753,334,- per month. Simultaneously, the variables of production costs, the amount of production, and the workforce have a significant effect on the business income of the amplang cracker industry. Partially shows that production costs, and the amount of production have a positive and significant effect on the business income of amplang crackers. Meanwhile, labor has no significant effect on the business income of the amplang cracker industry.
Keywords: Production, Labor, Revenue of amplang crackers industry
Pengaruh pendapatan asli daerah, dana alokasi umum, dan dana alokasi khusus terhadap pertumbuhan ekonomi Kabupaten/Kota Provinsi Jambi
Authors: Anjelina Pebby , Zamzami; Zamzami; , Nurhayani Nurhayani
Published: July 2021

This study aims, (1) To analyze the development of regional original income, general allocation funds, special allocation funds, and economic growth of Jambi Province Regency/City (2) To determine the effect of regional original income, general allocation funds, and special allocation funds on the economic growth of the Regency / City of Jambi Province partially and simultaneously. Data sourced from the Central Statistics Agency of Jambi Province and the Directorate General of Fiscal Balance with panel data analysis method and using descriptive analysis tools. Based on the results of data processing, the following results are obtained: first, the average development of regional original income variables, general allocation funds, special allocation funds, and economic growth fluctuates from year to year. second, (1) Regional original income and special allocation funds have a negative and significant impact on the economic growth of districts/cities in Jambi Province. (2) The general allocation fund has a negative and insignificant effect on the economic growth of districts/cities in Jambi Province.

Keywords: Economic growth, Local revenue, General allocation funds, Special Allocation funds Province.
Faktor-faktor yang mempengaruhi ekspor pala Indonesia ke Vietnam
Authors: Novidayanti Vivi , Hodijah Siti , Mustika Candra
Published: July 2021

The purpose of this study was to analyze the factors that influence Indonesia's nutmeg exports to Vietnam, with the variables of exchange rates, international prices, and Vietnam's gross domestic product. The data analysis method used is descriptive and quantitative methods, the data analysis tool used is the OLS (Ordinary Least Square) method. Includes annual data for 38 years, with secondary data sourced from the Directorate General of Plantations, Bank Indonesia, and the World Bank as research objects. The data analysis technique is multiple linear regression, partial hypothesis testing using the t-test, and simultaneously using the F-test with a significant level of 5%. Based on the results, it can be concluded that partially the exchange rate (NT) has a positive and significant effect on export volume (VE); international price (HI) has a negative and significant effect on export volume (VE), and Vietnam's gross domestic product (GDP) has a positive and significant impact on the export volume (VE) of Indonesian nutmeg.
Keywords: Export volume, Exchange rate, International price, Gross domestic product.
Analisis produktivitas unit usaha pada industri kecil pandai besi di Desa Koto Padang Kecamatan Tanah Kampung Kota Sungai Penuh
Authors: Ramadhani Elsya , Hari Prihanto Purwaka , Hardiani Hardiani
Published: July 2021

This study aims to analyze the productivity of business units and to analyze the effect of business capital, working capital, and labor on the productivity of business units in small blacksmith industries in Koto Padang Village, Tanah Kampung Subdistrict, Sungai Penuh City. This research is quantitative research and the type of data used in this study is primary data in the form of cross-section data on productivity levels, business capital variables, working capital, and labor. The sample in this study amounted to 43 respondents with the instruments used in the form of questionnaires and interviews. The data obtained were processed using SPSS20 with multiple linear regression analysis methods. The results of the study with a significant level of 10%, the business capital variable obtained a significant level of 0.060 with a significant value less than 0.1, meaning that business capital affects productivity. The working capital variable obtained a significant level of 0.037 with a significant value less than 0.1, meaning that working capital affects productivity. And the labor variable obtained a significant level of 0.288 with a significant value greater than 0.1, which means that the number of workers does not affect productivity.
Keywords: Productivity, Business capital, Working capital, Labor.
Analisis faktor-faktor yang mempengaruhi ekspor CPO provinsi Jambi ke Malaysia
Authors: Hardianto Usman , Hodijah Siti , Nurjanah Rahma
Published: July 2021

The purpose of the study was to determine and analyze the development of production, exchange rates, CPO prices, Malaysian GDP, and Jambi Province CPO exports to Malaysia and the effect of production, exchange rates, CPO prices, Malaysian GDP on Jambi Province CPO exports to Malaysia. The data used in this study is secondary data in the form of time series data for 2000-2017. The results show that the average development of Jambi Province CPO exports to Malaysia is 4.10% per year, Jambi Province CPO production is on average 4, 10% per year, the average exchange rate is 2.64% per year, the average CPO price is 8.63% per year, and Malaysia's GDP is 4.89% per year on average. Based on the results of multiple linear analyses, it can be concluded that CPO production, CPO prices, exchange rates, and Malaysian GDP together affect the volume of Jambi Province's CPO exports to Malaysia. While partially production and GDP have a negative and insignificant effect on Jambi Province's CPO exports to Malaysia, the exchange rate and CPO prices positively and significantly impact Jambi Province's CPO exports to Malaysia.
Keywords: Production, Price, Exchange rates, Gross Domestic Product
Analisis faktor - faktor yang mempengaruhi ekspor minyak kelapa sawit di Indonesia Tahun 2000-2019
Authors: Advent Roni , Zulgani Zulgani , Nurhayani Nurhayani
Published: July 2021

This research aims to analyze the development and contribution of the  investment labor, and GDP mining sector in the Bungo Distric,  The research was using Ordinary Least Square (OLS) method.  The result of this study indicates that, during the period of 2008-2017investement, labor and GDP mining sector in the Bungo Distric is experiencing developments that fluctuate, with an average of  GDP mining sector in the Bungo Distric 12,7 percent an annual, investmen 29,8 percent an annual and 2,6 percent to labor. Investmen contribution in the formation of the GDP mining sector in the Bungo Distric an average 45,2 percent. From the results of the regression shows independent variables simultaneously investment and labor effect on the dependent variables. While a partial workforce affects the PDRB while investments are not over the period of 2008-2017 years.

Keywords : Investment, Labor, GDP mining sector
The impact of board characteristics on earnings management
Authors: Aleqab Mahmoud Mohmad , Ighnaim Maha Mohammad
Published: July 2021

This study explores the effect of the board of directors’ characteristics on real earnings management in Jordanian non-financial companies listed on the Amman Stock Exchange. The sample size is 131 companies during the period of 2015–2017. The study uses a board of directors’ size, board members’ independence, board members’ financial experience, number of board meetings, membership in more than one board, and the ownership of board members of company shares to represent the board of directors’ characteristics. Real earnings management is measured using the Roychowdhury model (2006). A multiple regression analysis (panel data) is used to investigate the effect of the board of directors’ characteristics on real earnings management. The study found a negative and statistically significant impact for both: board members’ independence and board members’ financial experience on earnings management through real activities against the previous studies’ findings, this research measured the impact of real activities. On the other hand, the study did not find any statistically significant effect of the additional earnings management variables through actual activities
La Reforma Universitaria en la Institución Rosalina. El caso de la Universidad Autónoma de Sinaloa, 1966-1969
Authors: Sánchez Parra Sergio Arturo , Gil Pérez Anderson Paul
Published: July 2021

El presente artículo explica los procesos históricos que se desarrollaron en la Universidad Autónoma de Sinaloa (uas) en el periodo de la Reforma Universitaria a mediados de los años sesenta del siglo xx. Se propone que esta serie de reformas fueron inspiradas en el Manifiesto Liminar de la Universidad de Córdoba, Argentina, en 1918, con sus particulares adaptaciones al contexto regional de México. De ahí que los cambios académicos y administrativos impulsados por la Federación de Estudiantes Universitarios Sinaloenses (feus), con el aval de la rectoría de Rodolfo Monjaraz Buelna (1966-1970), hayan fortalecido dimensiones como la autonomía universitaria, el cogobierno, la vinculación de la uas con la sociedad y la modernización académica.
La enseñanza de la historia regional en Argentina: una mirada desde los actuales diseños curriculares de la provincia de Corrientes
Authors: Zapata Horacio Miguel Hernán , Portalis Antonia Elizabet
Published: July 2021

A partir del cruce de perspectivas de la historiografía, la didáctica y la enseñanza de las ciencias sociales, el artículo analiza el lugar que ocupa la historia regional en los Diseños Curriculares Jurisdiccionales vigentes en la provincia de Corrientes (Argentina) en el marco de las transformaciones de su sistema educativo a partir de la sanción de la nueva Ley Nacional de Educación (Ley Nº 26.206). El análisis de los contenidos específicos y de los distintos argumentos para su inclusión permiten sostener que la enseñanza del pasado regional detenta una centralidad innegable en los documentos curriculares oficiales, aunque su conceptualización aún conserva y reproduce los parámetros de la historiografía provincial más clásica y tradicional.
Discurso para el acto de recepción del título magíster honoris causa en Historia
Authors: De los Ríos Tobón Ricardo
Published: July 2021

En una ceremonia celebrada el viernes 27 de noviembre de 2020, la Universidad Tecnológica de Pereira entregó el título Magíster Honoris Causa en Historia al historiador Ricardo de los Ríos Tobón, como un reconocimiento a sus aportes al desarrollo de la historia regional del centro-occidente colombiano y a la conformación de entidades dedicadas a la promoción y divulgación del conocimiento histórico. Su discurso es una síntesis de su vida al servicio de la historia.
Sodium channel blockers in the management of long QT syndrome: a system review and meta-analysis
Authors: Yang Ying , Lv Tingting , Li Siyuan , Zhang Ping
Published: July 2021

Background: β-blockers are first-line therapy in patients with long QT
syndrome (LQTS). However, β-blockers had genotype dependent efficacy
(LQT1>LQT2>LQT3). Sodium channel blockers have
been recommended as add-on therapy for LQT3 patients. However, the
effect of sodium channel blockers in all LQT patients remains unknown.
Methods: We conducted a systematic electronic search of PubMed, Embase
and the Cochrane Library. Fixed effects model was used to assess the
effect of sodium channel blockers on QTc, cardiac events (CEs), and the
proportion of QTc≥500 ms and QTc≤460 ms in LQTS patients. Results:
Pooled analysis of 14 studies with 213 LQTS patients showed that sodium
channel blockers significantly shortened QTc by nearly 50 ms (MD -49.43,
95%CI -57.80 to -41.05, P<0.001), reduced the incidence of
CEs (OR 0.12, 95%CI 0.04 to 0.32, P<0.001) and the proportion
of QTc≥500 ms (OR 0.15, 95%CI 0.09 to 0.26, P<0.001), and
increased the proportion of QTc≤460 ms (OR 18.00, 95%CI 7.49 to 43.26,
P<0.001). Sodium channel blockers significantly shortened QTc
both in LQT3 and non-LQT3 patients, while the QTc shortening effect in
LQT3 was superior to that in non-LQT3 (57.39 ms vs. 36.61 ms).
Mexiletine, flecainide, and ranolazine all significantly shortened QTc,
and the QTc shortening effect by mexiletine was the best (60.70 ms vs.
49.08 ms vs. 50.10 ms). Conclusions: sodium channel blockers can be
useful both in LQT3 and non-LQT3 patients. Mexiletine, flecainide and
ranolazine significantly shortened QTc in LQTS patients, and the QTc
shortening effect by mexiletine was the best.
Non-reductive Homolytic Scission of Endoperoxide Bond for Activation of Artemisinin: The Bi-radical Perspectives
Authors: Sharma Shikha , Ali Ehesan
Published: July 2021

Artemisinin is the most successful antimalarial drug against malaria
caused by Plasmodium falciparum. Despite its tremendous success
and popularity in malaria therapeutics, the molecular mechanism of
artemisinin’s activity is still elusive. The activation of artemisinin,
i.e., cleavage of the endoperoxide bond at the infected cell that
generates radical intermediates and the subsequent chemical
rearrangements plays a key role in the antimalarial activities. In this
work, applying state-of-the-art computational techniques based on the
spin-constraint density functional theory (CDFT) along with ab
initio thermodynamics, we have investigated various key steps of the
molecular mechanism of artemisinin. The well-accepted artemisinin
activation process is the reductive heterolytic scission of the
endo-peroxide bond which is followed by subsequent chemical reactions
that propagate via mono-radical intermediates. Adopting CDFT
methodology, here we have investigated the possible alternative
‘biradical’ intermediates and their mechanistic pathways for the
subsequent chemical reactions. The change in Gibbs free energy
associated with the activation of artemisinin through
homolytic-scissoring (biradical) intermediate is quite competitive and
favorable compared to the reductive heterolytic-scissoring (monoradical)
process. This indicates the alternative possibilities for the biradical
activation process. The reported experimental EPR signals for the
biradicals especially for similar anti-malarial drugs like G3-factor
support our observations.
Lidocaine for dinutuximab associated pain? A multicenter retrospective observational cohort study
Authors: Featherly Julianna , Wojnowicz Sarabeth , Steidl Kelly , Burgess Jeni
Published: July 2021

Dinutuximab, an immune-mediated therapy used in the treatment of
high-risk neuroblastoma targets the protein disialoganglioside (GD2)
present on neuroblastoma cells, neurons, and peripheral nerve fibers.
Off target effects could lead to severe nerve pain. Pain regimens
including continuous infusion opioids are required during the first
treatment course. Our institution utilizes a combination of intravenous
(IV) lidocaine infusions and morphine for the treatment of
dinutuximab-associated neuropathic pain. The primary outcome of this
study was to compare morphine equivalents for cycle one of dinutuximab
at an institution that uses IV lidocaine (primary) versus those that do
not (comparison). Secondary outcomes included both dinutuximab infusion
time and safety of IV lidocaine. A retrospective, multi-centered,
electronic chart review was performed at three tertiary academic medical
centers. Patients between 0-18 years of age during their first course of
dinutuximab were included to evaluate the primary outcome of adjuvant
morphine equivalents needed. Total morphine equivalents at the primary
institution were 1.87 mg/kg vs 1.79 mg/kg at the comparison institutions
(p=0.413). Dinutuximab infusion time was significantly lower at the
primary institution: 610.5 minutes vs 676.23 minutes (p=0.046). Only one
patient at the primary institution experienced nausea, vomiting and
paresthesias. This study did not find a statistically significant
difference in morphine equivalents between patients who received IV
lidocaine and those who did not. However, we did find that use of IV
lidocaine resulted in a statistically significant lower dinutuximab
infusion time and that it is a safe adjuvant medication in the treatment
of dinutuximab-associated neuropathic pain.
Tofacitinib versus standard of care treatment in patients with COVID-19: a multicenter non-randomized controlled study
Authors: Moiseev Sergey , Bulanov Nikolay , Zykova Anastasiia , Brovko Michail , Novikov Pavel , Akulkina Larisa , Chichkova Natalia , Trushenko Natalia , Lukina Maria , Sorokin Yuriy , Tao Ekaterina , Filatova Ekaterina , Kitbalyan Aram , Potapov Pavel , Ermolova Lubov , Suvorova Olga , Vaglio Augusto , Kronbichler Andreas , Avdeev Sergey , Fomin Victor
Published: July 2021

This non-randomized controlled study aimed to assess the efficacy of
tofacitinib in reducing the risk of invasive mechanical ventilation or
death in patients with COVID-19. Patients with COVID-19 associated with
reduced oxygen saturation, increased C-reactive protein (≥50 mg/L),
and/or persisting fever were recruited. Tofacitinib was administered in
addition to standard of care therapy. Study outcomes were evaluated
separately in the groups of patients with oxygen saturation at rest
≤93% and >93%. Hazard ratios (HR) with 95% confidence
intervals (CI) were calculated using Cox regression analysis adjusted
for inverse propensity score weighting. Overall, 384 patients with
COVID-19 (212 males; median age 60 years) were included in our study and
were treated with tofactinib (n=131) or standard of care alone (n=253).
The percentages of patients who started mechanical ventilation or died
during hospitalization in the tofacitinib and control groups were 12.5%
(9/72) vs. 14.1% (26/185) among patients who required respiratory
support (HR 0.92, 95% CI 0.33-2.56), and 1.7% (1/59) vs. 4.4% (3/68)
in those with normal oxygen saturation (HR 0.83; 95 CI 0.07-9.44).
Tofacitinib did not reduce the risk of invasive mechanical ventilation
or death in patients with COVID-19, although the analysis of these
outcomes favored tofacitinib.