bluuebunny/crossref_metadata_2025 huggingface dataset:
CAPOEIRA COM A UFPE: LEITURA DA REALIDADE COM RELEVANTES AÇÕES-REFLEXÕES-NOVAS AÇÕES DE EXTENSÃO UNIVERSITÁRIA
Authors: Gerson Kohl Henrique , Trindade Machado Tatiane
Published: September 2023

Aqui relatamos parte da experiência acumulada junto ao projeto de extensão “Capoeira COM a UFPE: gingados transformadores ao ritmo de epistemologias críticas”, de fluxo contínuo, com ciclos interdependentes e dinamizados por diferentes rotinas temporais (diários, semanais, mensais, semestrais, anuais, dentre outros pontuais e/ou processuais), corrobora com a compreensão da indissociabilidade entre ensino, pesquisa e extensão. Estas ações-reflexões-novas ações buscam contribuir para a formação em comunidade através de intervenções que criem, ampliem e/ou consolidem mudanças em prol do bem-estar comum. Destarte, as intervenções seguem predominantemente norteadas pela multirreferencialidade entre diferentes áreas do conhecimento convergindo para duas linhas prioritárias definidas pelo Plano Nacional de Extensão, são elas: Educação e Cultura. O projeto, que tem a Capoeira como eixo estrutural fundamental, por ser uma prática social e configurar-se em uma luta, que se camuflou através da ginga em dança e tem resistido aos vários momentos da nossa sociedade, e como manifestação da cultura brasileira, converge junto aos projetos que buscam consolidar a práxis a partir de uma releitura criteriosa acerca do trato com os conhecimentos inerentes à capoeira, os quais são sustentados por princípios ancestrais que podem contribuir com a qualificação de cada ação-reflexão-nova ação que, neste caso, materializa a totalidade da intencionalidade intitulada “Capoeira COM a UFPE: Gingados Transformadores ao Ritmo de Epistemologias Críticas”. Enfim, corroboramos com todos (as) que queiram somar na produção que junte o saber acadêmico ao saber popular, entendendo que a extensão universitária no projeto em questão contribuiu para formação global e para o entendimento e respeito com as pessoas mais velhas, no que corresponde à idade, mas também a ancestralidade que a capoeira em sua prática carrega.
PRÁTICA DA CAPOEIRA DURANTE A PANDEMIA:
Authors: Schimith Mateus , Abade Sabrina
Published: September 2023

A capoeira enfrentou grandes mudanças socioculturais ao longo dos últimos séculos. Com a chegada da pandemia e da demanda por novas práticas de comportamento, os/as capoeiristas são levados a ressignificar suas ritualísticas e perceber outras abordagens metodológicas para o desenvolvimento do jogo. O artigo tem como objetivo reconhecer o cenário de adaptação da prática da capoeira e identificar caminhos desenvolvidos pela e para a capoeira após o isolamento social. Por meio de uma análise de ações desenvolvidas pela Mestra Sabrina Abade no Grupo de Capoeira Beribazu durante a pandemia, argumenta-se alternativas metodológicas para continuidade da prática.
Adventure Awaits: Exploring Mindfulness Practices During Outdoor Adventures Trips
Authors: Banaag Mike , Stuhr Paul T.
Published: September 2023

An argument can be made that integrating mindfulness practices (MPs) into Outdoor Adventure (OA) programming can help students develop and expand on a variety of social and emotional attributes, such as stress reduction, awareness of the present moment, relationship skills, and maintaining psychosocial equilibrium. However, there is a paucity of empirical inquiry that specifically aims to explore in-depth participant experience using MPs in OA programs. The purpose of this qualitative study was to examine the perceived benefits that MPs provided university students during OA trips. The term Mindful Lived-Outdoor Experience (MLOE) was conceptualized to define a participant’s experience during an OA trip with MPs included. The findings suggest MPs are a beneficial component in adventure programming. The MPs promoted opportunity for participants to reduce stress and socially engage during the OA activity.
Аpplication of Big Data in laboratory medicine. Russian Journal for Personalized Medicine
Authors: Ovchinnikova M. A. , Zhilenkova Yu. I. , Chernysh N. Yu.
Published: September 2023

The term “big data” (Big Data) refers to data sets, covering the excessive difference in differences between databases in the storage, management and analysis of information. The emergence of big data application algorithms has become the consumption of resources that use  resource resources for information processing and computer calculations for the purpose of  big data for statistical processing, analysis, forecasting and decision making. In laboratory  practice, with a large amount of practical digital information, the use of big data is not currently widespread. The purpose of this work is to conduct a retrospective review of the literature  on the use of big data in the field of laboratory medicine in the period 2018–2023. and evaluating the results of practical developments, benefits and achievements associated with big data  analytics in the field of laboratory.
Case of successful surgical treatment of the aorto-bifemoral re-occlusion with both lower limbs dry gangrene formation
Authors: Puzdriak P. D. , Shlomin V. V. , Rzaev E. F. , Zhdanovich K. V. , Shatil M. A. , Voskresensky M. A. , Bondarenko P. B.
Published: September 2023

The paper demonstrates a clinical case of open surgical re-interventional on the abdominal aorta 8 years later after primary aortofemoral bypass through the right and left retroperitoneal accesses. Severe ischemic damage to the tissues of both lower extremities required repeated vascular reconstruction. The tactics of repeated retroperitoneal intervention on the aorta was chosen, while the access could be expanded to thoracophrenolumbotomy. Due to the pronounced cicatricial process in the retroperitoneal space and intraoperative damage to the ureter, the branches of the prosthesis were performed in an atypical manner.
Wiejska rodzina nauczycielska jako specyficzne środowisko wychowawcze. Na przykładzie (auto)biografii Jana Woskowskiego, łódzkiego socjologa wychowania (1921–2015)
Authors: Dzwonkowska-Godula Krystyna , Średziński Stanisław Andrzej
Published: September 2023

The aim of the article is to present a process of socialisation in a teachers’
family living in rural areas in interwar Poland. These were the times when the
Polish public education was only being created. Rural teachers, like Jan
Woskowski’s parents, belonged to local intellectual elites and were identified as
local leaders and cultural animators. This sociologist of education underlined in
his memoirs their key role in shaping him as a man and a scientist. The educational,
cultural and social activity of his parents inspired him to deal with different
aspects of education in his scientific work. In numerous studies and publications
he undertook such issues as social conditions for the formation of an
institution of school and the teaching profession, their functions in society and
social status of teacher.
The article is based on family stories and diaries written by Jan Woskowski
and his father Stanislaw.
In dogs diagnosed with osteoarthritis, how safe and effective is long-term treatment with bedinvetmab in providing analgesia?
Authors: Kronenberger Katrin
Published: September 2023

To aid interpretation, certain statements in the Knowledge Summary have been clarified. Refer to the full text and PDF for these amendments and corrections.
Analysis and design of algorithms for the manufacturing process of integrated circuits
Authors: Fleytas Sonia , Pinto Diego , Colbes Jose
Published: September 2023

The stage of transporting semiconductor chips from the wafer to the support strip is crucial in the integrated circuit manufacturing process. This process can be modeled as a combinatorial optimization problem where the objective is to reduce the total distance the robotic arm must travel to pick up each chip and place it in its corresponding position within the support structure. This problem is of the pick-and-place type and is NPhard. The (approximate) solution proposals of state-of-the-art methods include rulebased approaches, genetic algorithms, and reinforcement learning. In the present work, one of these methods is analyzed, which models the problem as one of binary integer programming and proposes a genetic algorithm. Based on this analysis, we proposedand evaluated other methods, including a greedy algorithm and a genetic algorithm that improve the state-of-the-art results for test cases usually used in the literature. Additionally, the results obtained from a new ILP model for this problem indicate that the genetic algorithm results are very close to the optimal values.
Rancang Bangun Chatbot Pengaduan Kekerasan Perempuan Anak Dengan Metode Fuzzy String Matching Dan Enhanced Confix Stripping Stemmer
Authors: Billah Al Muhtadi , Wulandari Diah Ayu Retnani , Auliya Yudha Alif
Published: September 2023

Violence against women is a serious issue affecting many individuals in society. In Indonesia, including Kota Probolinggo, the number of cases of violence against women remains high. This research aims to design a chatbot application as a means for reporting violence against women and children (VAWC) in Kota Probolinggo. The application provides an anonymous and safe space for victims to report their complaints without revealing their identities. Additionally, the chatbot delivers information and education about different types of violence against women and preventive measures. The development of the chatbot application utilizes Fuzzy String Matching, Enhanced Confix Stripping Stemmer, and preprocessing methods to enhance data search accuracy and provide appropriate responses to users. The testing results show that the chatbot offers responses with satisfactory accuracy. Leveraging AI technology in the form of a chatbot is expected to provide an effective solution in addressing and preventing violence against women, offering a secure and anonymous platform for victims to report incidents. The application is envisioned to offer better support and assistance to victims of violence.

The chatbot application implements fuzzy string matching, the Levenshtein distance algorithm, and Enhanced Confix Stripping Stemmer to process user input before matching it with the database. During the Enhanced Confix Stripping Stemmer process, sentences are transformed into an array of basic words, enhancing the accuracy of data matching when using fuzzy string matching and the Levenshtein distance algorithm. Testing results indicate a 4.77% difference between manual calculations and the chatbot system. This difference may be attributed to variations in text processing and other factors.
Uma certa pandemia em documentos
Authors: Stigger David Rodrigues
Published: September 2023

O presente trabalho pretende proporcionar condições para uma interpretação da pandemia de Covid-19 entre os povos indígenas no Ceará a partir da análise de múltiplos documentos. Para isso, utiliza-se de um arcabouço teórico-metodológico fundamentado na antropologia de documentos, com foco nos parâmetros metodológicos elaborados pela tradição histórica da micro-história italiana. A pesquisa utilizou-se de documentos produzidos por diferentes sujeitos, como a Federação dos Povos e Organizações Indígenas do Ceará, o Ministério Público Federal e matérias jornalísticas; a fim de compreender os modos pelos quais os povos indígenas no Ceará se organizaram coletivamente para o enfrentamento da pandemia de Covid- 19.
Deciphering the interaction mechanism between copper and polysulfides for enhanced performance and cost-efficiency in quasi-sodium-sulfur batteries
Authors: Song Haobin , Li Tong , He Tingting , Chen Guanghui , Deng Chengjiang , Kong Dezhi , Yan Dong , Yang Hui Ying , Huang Shaozhuan
Published: September 2023

Room-temperature Na-S batteries with Al current collectors face the long-standing challenges of poor cycling performance and rate capability due to the serious sodium polysulfides (NaPSs) shuttling and sluggish reaction kinetics. Here, we demonstrate that a high-performance and low-cost quasi-Na-S battery can be realized by using the Cu@carbon nanotube (CNT) cathode host and unconventional Cu current collector (Cu-CC) in an ether electrolyte. Detailed ex-situ characterizations reveal that the Cu@CNT/S was transformed to NaPSs anchoring on Cu7S4 nanocrystals (~11 nm) during the cycling, forming the NaPS@Cu7S4/CNT cathode with robust sulfur immobilization and enhanced Na+ reaction kinetics. Moreover, the chemical interaction between NaPSs and Cu-CC in situ creates a robust Cu-CC/electrode interface with ultra-small resistance (< 4 Ω), greatly improving the electrode stability and charge transfer kinetics. The synergy of efficient NaPSs trapping and favorable Cu/electrode interface endows the quasi-Na-S battery with a moderate discharge plateau (around 1.2~1.75 V), excellent rate capability (396.9 mAh g-1 at 10 A g-1), and ultra-stable cycling performance (nearly no capacity decay over 1190 cycles). These features make it quite suitable for stable and cost-sensitive grid-scale applications.
DETERMINATION OF OPTIMAL PACKAGES OF ENERGY EFFICIENT MEASURES FOR PUBLIC BUILDINGS
Authors: Chernetska Yu. , Borychenko O. , Yehorenko A.
Published: September 2023

The paper is devoted to the problem of improving the energy efficiency of public buildings maintained with funds from the state and/or local budgets. Optimization modeling is proposed as an instument to determine the optimal packages of energy efficiency measures according to the criterion of maximum achieved savings of fuel and energy resources. Approbation of the mathematical model on actual data has shown its practical value - depending on a given budget, the optimal packages of energy efficiency measures for public buildings (on the example of Zaporizhzhia city) are determined. Based on the results of computational experiments, energy efficiency measures with the best and worst ratios of implementation costs and achieved savings of fuel and energy resources were identified. The impact of additional constraints on the composition of an optimal package of energy efficiency measures was shown to make informed and rational decisions on investing in energy efficiency improvement projects for public buildings.
Основні функції управління видавництвом в умовах російсько-української війни
Authors: Шевченко І. Б. , Кір’як В. С.
Published: September 2023

Висвітлено основні зміни у функціонуванні видавничого бізнесу після початку повномасштабного вторгнення рф на територію України. Визначено, що російсько-українська війна вплинула на перехід видавництв на нові формати діяльності, спричинений кризовими явищами в усіх галузях економіки України, обмеженими потужностями виробництв, ускладненими й розосередженими умовами роботи та загальним зниженням купівельної спроможності серед населення, зокрема, на тимчасово окупованих і прифронтових територіях.
Особистісно орієнтований підхід під час підготовки студентів спеціалізації «видавнича справа та редагування»
Authors: Фіялка С. Б. , Гончарук Т. Г.
Published: September 2023

В епоху соціально-культурних трансформацій воєнного часу та зростання масштабів охоплення студентів дистанційною освітою актуалізується особистісна зорієнтованість навчання, яка передбачає використання методів проблемних ситуацій, диференційоване навчання, дискусії тощо. При цьому роль викладача трансформується з традиційного «джерела знань» до тренера, ментора, консультанта. Сучасне навчання має відповідати здібностям, можливостям, мотивації та інтересам кожної особистості; передбачати діалогічність, діяльнісно-творчий характер; бути спрямованим на підтримку індивідуальних запитів здобувача освіти; передбачати альтернативи стандартним шляхам вирішення проблем.
Розробка сувенірної продукції для НН ВПІ КПІ ім. Ігоря Cікорського
Authors: Фісенко Т. В. , Балюн О. О. , Григоренко А. В.
Published: September 2023

Кожна компанія прагне зберігати зв’язок зі своїми клієнтами та аудиторією. Університети не є винятком, оскільки це забезпечує залучення нових студентів і підвищує лояльність до бренду серед працівників та випускників. Під час дослідження було вивчено наукову основу створення, випуску та розповсюдження сувенірної продукції, зокрема для ЗВО. Ці знання були втілені в практичних результатах, а саме — створенні сувенірної продукції для НН ВПІ.
Новітні терміни медіадидактики в структурі розділів спецкурсу «Професійно орієнтовна медіаосвіта»
Authors: Онкович Г. В.
Published: September 2023

У статті розглянуто основні терміни галузі медіадидактики, як то медіаінформаційна грамотність, медіадидактика вищої школи, медіакомпетентність, медіаосвітні технології, медіакультура особистості студента, медіаграмотність, медіакомпетентність та медіаобізнаність, як словотворче гніздо цієї галузі. Простежено історіографію впровадження спецкурсу «Медіаосвіта» на українських теренах. Введено до наукового обігу поняття «професійно орієнтована медіаосвіта», що вперше з’явилося в публікаціях часопису «Вища освіта України».
Проблематика війни в Україні у пресі і медіа Польщі та України: проба огляду
Authors: Янішевський О. О.
Published: September 2023

У статті подано огляд ринку польської преси в контексті подій в Україні протягом 2022 року. Зазначається, що польська преса (передусім друкована), як і польська держава в цілому на офіційному рівні, не залишилася осторонь проблем українського народу, активно включилася в дискурс допомоги Україні на рівні заангажованих коментувань подій, наведення об’єктивних фактів війни, побуту біженців, соціальних комунікацій з польськими громадянами. Підкреслюється, що польська преса миттєво реагує на усі виклики, проблеми, що постають у тісній взаємодії та співжитті ще донедавна віддалених одні від одних людей.
Медіапроєкти психологічної підтримки дітей під час війни
Authors: Галілейська O. O.
Published: September 2023

Актуальність медіапроєктів психологічної підтримки дітей є беззаперечною, адже війна росії проти України все ще триває. Метою нашого дослідження є охарактеризувати медіапроєкти, як комунікаційні інструменти, серед яких інформаційний комікс для дітей у воєнний час, медіапроєкт у відеоформаті «Психологічна турбота від Світлани Ройз», «Поруч», «Діти Героїв», «Show and Tell» та онлайн-посібник «Коли світ на межі змін: стратегії адаптації.
OSINT Time Series Forecasting Methods Analysis
Authors: Lande Dmytro , Feher Anatolii
Published: September 2023

Time series forecasting is an important niche in the modern decision-making and tactics selection process, and in the context of OSINT technology, this approach can help predict events and allow for an effective response to them. For this purpose, LSTM, ARIMA, LPPL (JLS), N-gram were selected as time series forecasting methods, and their simple forms were implemented based on the time series of quantitative mentions of nato, himars, starlink and cyber threats statings obtained and generated using OSINT technology. Based on this, their overall effectiveness and the possibility of using them in combination with OSINT technology to form a forecast of the future were investigated.
THE STRATEGIC AND SECURITY CONCEPT FOR THE COUNTRIES OF SOUTHEAST EUROPE
Authors: m m
Published: September 2023

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Türkiye’de Finansal Gelişmenin İmalat Sanayi ve İnşaattan Kaynaklanan CO2 Emisyonları Üzerindeki Etkisi: Fourier ADL Yaklaşımından Kanıtlar
Authors: KOÇAK Sinem
Published: September 2023

Bu çalışmanın amacı, finansal gelişmenin imalat sanayi ve inşaattan kaynaklanan CO2 emisyonları üzerindeki uzun dönemli etkisini Fourier ADL yaklaşımını ve tam değiştirilmiş en küçük kareler (FMOLS) tahmincilerini kullanarak incelemektir. Türkiye ekonomisi için 1985-2014 döneminin analiz edildiği çalışmada yıllık veri setinden yararlanılmıştır. Çalışmayı literatürden farklılaştıran özellik, analizin sektörel bazdaki CO2 emisyonlarına odaklanırken diğer taraftan da Türkiye ekonomisi için değişkenler arasındaki ilişkiyi ileri bir ekonometrik yaklaşım çerçevesinde ilk kez araştırıyor olmasıdır. Fourier ADL yaklaşımından elde edilen bulgular, değişkenler arasında eş-bütünleşme ilişkisinin varlığını ortaya koymaktadır. FMOLS yönteminden elde edilen uzun dönem tahminleri ise finansal gelişmenin, imalat sanayi ve inşaattan kaynaklanan CO2 emisyonları üzerindeki etkisinin negatif ve istatistiksel olarak anlamlı olduğunu göstermektedir. Elde edilen tüm bu bulgular, finansal gelişmenin Türkiye örneğinde imalat sanayi ve inşaattan kaynaklanan CO2 emisyonlarını azaltarak çevre kalitesinin artmasına katkı sunduğunu kanıtlar niteliktedir.
ENHANCED DIAGNOSTIC TECHNIQUES FOR MARINE DIESEL ENGINES: ACHIEVING IMO DECARBONIZATION COMPLIANCE
Authors: Varbanets R. , Minchev D. , Savelieva I. , Rodionov A. , Mazur T. , Psariuk S. , Bondarenko V.
Published: September 2023

This paper discusses hardware-based methods for monitoring the operational parameters of marine diesel engines and online mathematical modeling techniques (digital twins) for calculating the emissions of CO2, NOx, soot, and other harmful pollutants. It is demonstrated that measuring and analyzing the engine's vibrational diagrams in parallel with gas pressure diagrams in the cylinders allows the evaluation of the actual fuel injection and gas distribution timings. The obtained data is used to refine the mathematical model of the engine's working process, which determines the engine's indicator parameters and power, as well as the emission of harmful substances that need to be monitored in compliance with current IMO requirements. The authors have accumulated experience in using the discussed hardware-based methods for diagnosing marine engines during operation. The hardware and software methods discussed have been implemented into a real-time system for in-service diagnostics of marine engines. The system is designed based on a modern dual-core controller with high performance and low power consumption, incorporating a high-speed ADC with sufficient capability to monitor the working process with a 0.1-degree crankshaft rotation resolution for all types of marine main and auxiliary engines. The system also utilizes wireless data transmission technology. A contemporary Android/iOS smartphone or tablet serves as the computational and graphical component of the system. This real-time system enables the utilization of all the advantages of parallel pressure and vibroacoustic analysis, including real-time determination of key operating parameters, identification of top dead center position, and evaluation of fuel delivery and gas distribution phases. Additionally, it harnesses the benefits of employing a digital twin—an online mathematical model of the engine cylinder's working process. These solutions will enhance diagnostic quality and, ultimately, improve the operational efficiency of marine engines by reducing operational costs and extending the period of reliable, trouble-free operation.
APPLICATION OF VACUUM SUCTION CASTING OF IRON-CARBON ALLOYS FOR THE PRODUCTION OF ENGINE PARTS
Authors: Klymenko L.P. , Pryshchepov O.F. , Andrieiev V.I. , Shchesiuk O.V. , Sluchak O.I. , Bolan Kong
Published: September 2023

The use of vacuum suction casting technology for iron-carbon alloys for the production of internal combustion engine parts will improve their quality and wear resistance, preserve metal, and reduce emissions. The technology is widely used for non-ferrous alloys. At the same time, its implementation for iron-carbon alloys (including cast iron) in modern engine construction requires careful scientific and practical preparation. Problematic tasks arise when improving the pneumatic system of vacuum suction (large volumes of gas release), the stability of the metal pipeline (thermal overload in a high-temperature cast iron melt), and the stabilization of the casting microstructure (high-speed crystallization). The authors suggest using a specialized titanium alloy VT3-1 for the metal pipeline, for which the article calculates thermal loads during cyclic operation in the “Deep – take-out” mode for the use of cast irons of the SCH25 and VCH50-1.5 grades. For reliable operation of the metal pipeline and the absence of solidification of the melt on its inner surface, a thermal calculation method was develop, which allows determining the time of heat removal of overheating of the melt according to the diameter of the metal pipeline. The pneumatic system of the vacuum unit is supplement with a patented gas jet ejector, which, in combination with a powerful shop compressed air system, provides a full gas outlet. Applying the developed law of change in the discharge between atmospheric pressure and pressure in the mold cavity, the authors of the article regulate the rate of crystallization of castings, which makes it possible to form much smaller phases of perlite in the microstructure and reduce the presence of Ferrite. At the Enterprise "Pervomaiskdizelmash" using vacuum casting technology, blanks of guide bushings of engine valves 6CHN25/34 made of cast iron SCH25 and VCH50-1,5, as well as oils of piston rings made of cast iron VCH50-1,5 were obtained. The obtained parts showed an increased service life by 15-30%. Vacuum casting technology is recommend for iron-carbon alloys in the production of engine parts.
Evaluation of healthcare professionals' knowledge on breastfeeding
Authors: BRAHAM Amira , JDI Imene BEN , ZOUKAR Olfa , BERGAOUI Haifa , CHERIF Amani
Published: September 2023

Background
Less than half of infants are exclusively breastfed for the first six months of life. This raises questions about the role of support provided to breastfeeding mothers in helping them address everyday questions and challenges.
Methods
Our study aimed to evaluate healthcare professionals' knowledge on breastfeeding. Methodology: This was a descriptive study conducted among healthcare professionals. Data collection was done using a questionnaire, and the data were gathered, coded, and entered into SPSS software version 20.
Results
Our study included 86 healthcare professionals, including midwives (n = 39), midwifery students (n = 33), medical interns (n = 10), and obstetrics and gynecology residents (n = 4). The evaluation of knowledge on hygiene and dietary rules yielded an average score of 0.53. The theme related to complications occurring in mothers and infants had an average score of 0.55 out of 1 (0.1; 0.9). Regarding the benefits of breastfeeding, only 49% were aware of the benefits for the mother, compared to 42.3% for the baby. A mean score of 0.51 was attributed to knowledge about treatments that can be taken during breastfeeding.
Conclusions
The successful implementation and continuation of breastfeeding require the collective efforts of various stakeholders, particularly healthcare professionals. Our study highlighted a lack of knowledge among the surveyed healthcare professionals regarding breastfeeding.
Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons
Authors: Tomita Taisuke , Yoshida Fumiaki , Nagatomo Ryota , Kimura Misaki , Shun Shiyori , Nao Yosuke , Takatori Sho , Ito Genta , Utsunomiya Shun , Ogawa Koichi , Maeda Kazuma , Takemoto Hiroshi , Lichtenthaler Stefan
Published: September 2023

Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impaired social communication and repetitive behaviors. In recent years, a pharmacological mouse model of ASD involving maternal administration of valproic acid (VPA) has become widely used. Newborn pups in this model show an abnormal balance between excitatory and inhibitory (E/I) signaling in neurons and exhibit ASD-like behavior. However, the molecular basis of this model and its implications for the pathogenesis of ASD in humans remain unknown. Using quantitative secretome analysis, we found that the level of leucine-rich repeat and immunoglobulin domain-containing protein 2 (Lingo2) was upregulated in the conditioned medium of VPA model neurons. This upregulation was associated with excitatory synaptic organizer activity. The secreted form of the extracellular domain of Lingo2 (sLingo2) is produced by the transmembrane metalloprotease ADAM10 through proteolytic processing. sLingo2 was found to induce the formation of excitatory synapses in both mouse and human neurons, and treatment with sLingo2 resulted in an increased frequency of miniature excitatory postsynaptic currents in human neurons. These findings suggest that sLingo2 is an excitatory synapse organizer involved in ASD, and further understanding of the mechanisms by which sLingo2 induces excitatory synaptogenesis is expected to advance our understanding of the pathogenesis of ASD.
A new probability adjustment method for combining conflicting evidences: application in classifiers combination
Authors: Jebari Chaker , Jin LeSheng , Yager Ronald R.
Published: September 2023

Dempster-Shafer (DS) evidence theory has been widely used in information fusion. However, combining conflicting evidences is still an open question despite the existence of many proposed studies to improve the DS theory combination rule. In this paper we propose an improved probability adjustment method to combine evidences based on their ranks. The idea of our method is to divide each piece of evidence by its rank, assuming that the evidences produced by each source of information are sorted descendingly. The obtained evidences are normalized, averaged and then the DS combination rule is applied. The main objective of our method is to employ the evidence rank to adjust it by giving high support to highly ranked evidences and low support to lowly ranked evidences. Through a numerical example, we proved that the proposed method is more efficient and generates better results that those achieved by many other DS based combination methods. Moreover, we applied our method in combining the outputs generated by multiple single-label classifiers. Using many real-world classification datasets, we compared our method with other DS combination methods, non-learning combination rules and ensemble classifiers. The achieved results shows that our proposed method performs better using most of the datasets.
Projected intensification of subsurface marine heatwaves under climate change
Authors: Konsta Katerina , Doxa Aggeliki , Katsanevakis Stelios , Mazaris Antonios D.
Published: September 2023

Marine heatwaves (MHWs) are periods of abnormally warm ocean temperatures that severely impact marine ecosystems. Although they can propagate beneath the ocean’s surface, MHWs are typically assessed using sea surface temperatures. Here, we investigated the future evolution and depth penetration of MHWs across the Mediterranean basin. Our analysis revealed that MHWs will become more intense and persistent by the end of the century, both on the surface and, especially, in deeper waters. Near the surface, we projected on average 51 annual MHW days and a mean intensity of 1.5°C, whereas at depths below 1000 m, MHWs may occur up to 340 days annually, with an intensity of 0.4°C. These findings highlight that MHWs penetrate deep into the ocean, posing a severe threat to marine life and ecosystems that are often overlooked, particularly in marine subsurface environments.
Synthesis of magnetic Fe3O4@SiO2 nanoparticles decorated with polyvinyl alcohol for heavy metal ion removal from aqueous solution
Authors: Asgharinezhad Ali Akbar Akbar , Esmaeilpour Mohsen , Afshar Majid Ghahraman
Published: September 2023

This work describes Fe3O4@SiO2 core-shell nanoparticles functionalized with polyvinyl alcohol and its application for the removal of Cu(П) and Cd(П) ions by analytical methods under diverse experimental parameters. Surface chemistry and morphology during functionalization of Fe3O4@SiO2 NPs were monitored using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX), vibration sample magnetometer (VSM), transmission electron microscope (TEM), field emission scanning electron microscope (FE-SEM), dynamic light scattering (DLS). The performance of the polyvinyl alcohol modified magnetic nanoparticles for metal ions removal was evaluated by changing five process variables: contact time of adsorbent, temperature, pH, adsorbent dosage and the selective removal. The adsorption isotherm studies of the novel adsorbent in removing heavy metals from wastewater showed that the maximum absorption amounts of Cu(П) and Cd(П) were 1.57 and 0.99 mmol/g at 35 oC. According to the results, the prepared composites possess excellent adsorption efficiency to be applied for the preconcentration of heavy metal ions in the field of water treatment. The Fe3O4@SiO2-TCT-PVA adsorbent is completely separated from the aqueous solution under external magnetic field for five consecutive cycles without significant loss of activity.
Healthcare Performance of Leprosy Management in Peripheral Health Facilities of Dhanusa and Mahottari, Nepal
Authors: Mahato Ram Kumar , Ghimire Uttam , Bajracharya Bijay , KC Binod , Bam Deepak , Ghimire Deepak , Pyakurel Uttam Raj , Hayman David TS , Pandey Basu dev , Das Chuman Lal , Paudel Krishna Prasad
Published: September 2023

Background
The global elimination of leprosy transmission by 2030 is a World Health Organization (WHO) target. Nepal’s leprosy elimination program depends on early case diagnosis and the performance of health workers and facilities. The knowledge and skills of paramedical staff (Leprosy Focal Person, LFP) and case documentation and management by health facilities are therefore key to the performance of health care services.
Methods
The performance of health workers and facilities was evaluated through a combined cross-sectional and retrospective study approach of 31 health facilities and their LFPs in Dhanusa and Mahottari Districts in Madhesh Province, Nepal. An average of 6 patients (paucibacillary, PB, or multibacillary, MB) per health facility registered within the 2018/2019 fiscal year were also enrolled in the study. LFP knowledge (e.g., of the three cardinal signs) and skills (e.g., nerve palpation) and facility processes (e.g., record keeping) were scored (e.g., 0, 1) and then rescaled to a proportion, where 1 is perfect. Internal benchmarking was used to guide performance management.
Results
Overall LFP knowledge and skill scores ranged from 0.16 to 0.63 (median 0.53, 95% confidence interval (CI), 0.46-0.6). Case documentation scores ranged from 0.15 to 0.87 (median 0.37, 95% CI 0.36-0.38), case management scores from 0.38 to 0.79 (median 0.54, 95% CI 0.53-0.55) and overall healthcare scores from 0.36-0.62 (median 0.48, 95% CI 0.47-0.49). Leprosy-related training was significantly related to the knowledge and skills of the health workers. All identified cases (n =187) adhered to the complete treatment and release after treatment (RFT) scheme, out of which 84.5% were satisfied with the service they were provided. Leprosy disability and ear hand and feet (EHF) scores were not significantly reduced in treated patients during the study period, but counseling by LFPs significantly improved cases’ positive beliefsand practices regarding self-care.
Conclusion
Overall leprosy care performance was low (43%) and can be improved by evidenced-based training, onsite coaching, monitoring, and supervision to facilitate leprosy transmission elimination. The results highlight many of the challenges facing leprosy elimination programs.
Elevated expression of Toll-like receptor 7 and its correlation with clinical features in patients with primary Sjogren's syndrome
Authors: Yang Huimin , Sun Chao , Wang Xin , Wang Tao , Xie Changhao , Li Zhijun
Published: September 2023

Background
The labial salivary glands (LSGs) are important for the diagnosis, evaluation of therapeutic efficacy, and genetic analyses of primary Sjogren's syndrome (pSS). In autoimmune diseases, the recognition of self nucleic acids and viral RNA and DNA through endogenous Toll-like receptor(TLR) triggers the production of type I IFN and pro-inflammatory cytokines, leading to the occurrence and progression of the disease. Here, we detected the expression of TLR7 in LSGs and analyse its correlation with clinical features and serum cytokines in pSS patients.
Methods
LSGs and serum samples were obtained from 56 pSS patients and 19 non-SS patients (non-pSS patients). The expression of TLR7 in the LSGs was evaluated with immunohistochemistry. The serum levels of interferon-α (IFN-α) and interleukin-6 (IL-6) were quantified by ELISA. Laboratory parameters were measured by clinical standard laboratory techniques.
Results
TLR7-positive cells in pSS were localized in the ductal epithelial cells and lymphocytes of LSGs. The expression of TLR7 was upregulated in pSS patients compared with controls. Patients with anti-Ro52 antibody positivity showed higher TLR7 levels than those who were negative but not those with anti-Ro60 and anti-SSB. TLR7 levels were positively associated with the levels of IgG, IgA, ANA, IL-6, IFN-α and serum globulin but were not associated with IgM, C3, C4, or rheumatoid factor (RF) in serum.
Conclusion
TLR7 may be involved in the inflammatory response and the production of antibodies in pSS and plays an important role in local and systemic pSS manifestations. This research showed that TLR7 is involved in pSS pathogenesis.
Increased levels of APOA4 in cord blood in maternal major depressive disorder
Authors: Matsuo Seiko , Moriyama Yoshinori , Ushida Takafumi , Imai Kenji , Tano Sho , Miki Rika , Yoshida Kosuke , Yokoi Akira , Kajiyama Hiroaki , Kotani Tomomi
Published: September 2023

Background: Prenatal maternal depression affects neurodevelopment in the offspring. This study aimed to investigate the cord blood profile of mothers with major depressive disorder (MDD).
Methods:Liquid chromatography-tandem mass spectrometry (LC-MS) was performed using umbilical cord blood from women with MDD and gestational age-matched controls (Control). The levels of several differentially expressed proteins in cord blood were compared between the two groups using enzyme-linked immunosorbent assays.
Results: The proteomic profiles of cord blood differed between the MDD and Control groups, including the pathways on regulation of plasma lipoprotein particle levels and synapse organisation. Only apolipoprotein A4 (APOA4) levels were significantly increased in the cord blood of the MDD group. APOA4 levels in the maternal serum were also significantly higher in the MDD group than in the control group (p <0.05). APOA4 levels were higher in cord blood than in maternal serum.
Conclusions: APOA4, a biomarker of depression, was increased in neonates at birth exposed to maternal MDD in utero. Thus, our results suggest that the risk of MDD in children born to MDD mothers might be related to increased APOA4 levels at birth, although further studies are required.
Meta-analysis of the Diagnostic Value of exosomal microRNA in Renal Cell Carcinoma
Authors: Qingru Li , Jing Tian , Binyi Li
Published: September 2023

Aim
This study aims to evaluate the feasibility of using extracellular vesicle-derived miRNA as a biomarker for the diagnosis of renal cell carcinoma through meta-analysis.
Methods
Clinical studies on the diagnosis of renal cell carcinoma using extracellular vesicle-derived miRNA were retrieved from various databases including PubMed, Web of Science, Cochrane Library, Embase ,CNKI, Wanfang Database, VIP Database and SinoMed. After screening and extracting relevant data, the included articles’ quality were assessed with QUADAS-2 tool. Meta-disc 1.4 software was used to analyze the heterogeneity of threshold/non-threshold effects in the included literature, and use Stata MP 16.0 to calculate sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, area under the curve, diagnostic odds ratio and publication bias.
Results
A total of 11 articles were included. Results showed that the Spearman correlation coefficient was 0.319 (P = 0.075 > 0.05), indicating no threshold effect. The pooled sensitivity was 0.73 (95%CI: 0.68–0.78), pooled specificity was 0.81 (95%CI: 0.76–0.85), pooled positive likelihood ratio was 3.80 (95%CI: 3.02–4.77), pooled negative likelihood ratio was 0.33 (95%CI: 0.28–0.40), and the diagnostic odds ratio was 11.48 (95%CI: 8.27–15.95). The area under the curve was 0.84 (95%CI: 0.80–0.87). There was no publication bias detected in this study.
Conclusion
The expression levels of extracellular vesicle miRNAs hold an important value in the diagnosis of renal cell carcinoma. However, due to the limited number of included studies and heterogeneity among them, further clinical research is necessary.
Inhibition of E. coli and C. albicans with a Dietary Women’s Health Formulation
Authors: Robins Howard , Kamarei A. Reza , Finkelstein Eric
Published: September 2023

Background
Two common infections in women are urinary tract infections (UTIs) and vaginal candidiasis (VC). The focus of this research project was to counter the root causes of these two infections, namely, Escherichia coli (E. coli) and Candida albicans (C. albicans).
Purpose
The purpose of this research project was to develop a dietary formulation for women’s health that inhibits both E. coli and C. albicans.
Materials & Methods
We designed a propriety blend of five strains of Bifidobacteria, ten strains of Lactobacilli, and organic cranberry powder. For the carriers, we chose a proprietary blend of organic red fruit and vegetable juices. The probiotics were added to a sterilized blend of juice and cranberry powder. Three strains of E. coli and two strains of C. albicans were used in this study.
Results
While E. coli in the control sample showed a typical growth curve for microorganisms, E. coli growth was completely inhibited in the test sample from days 1 to 5. Similarly, while C. albicans in the control sample showed overwhelming uncountable growth, C. albicans growth in the test sample was reduced by 70% on day 1 and was completely inhibited from day 2 to day 5.
Conclusion
The results of this in vitro study indicate that E. coli O157:H7 and C. albicans (the microorganisms responsible for UTI and VC) were completely inhibited by a healthy dietary formulation for women. These findings have advanced our knowledge of the inhibition of two pathogens responsible for two common medical problems in women.
Peripheral blood DNA methylation analysis reveals epigenetic marks associated with hereditary breast and ovarian cancer risk
Authors: Paniagua Felipe Vaca , Cruz Miguel Ruiz de la , Gregorio Héctor Martínez , Díaz-Velásquez Clara , Ambriz-Barrera Fernando , Resendiz-Flores Norma , Gitler Rina , Rojo-Castillo María , Pradda Didier , oliver Javier , Perdomo Sandra , Gómez-García Eva , De-La-Cruz-Montoya Aldo , Terrazas Luis , Torres-Mejía Gabriela , Hernández-Hernández Fidel de la Cruz
Published: September 2023

Background. Only a fraction of 15-20% of hereditary breast and ovarian cancer (HBOC) patients carry pathogenic coding genetic variants. Therefore, other pathogenic molecular mechanisms could explain the etiopathology of the syndrome. Aberrant germline DNA methylation in tumor suppressors has been reported in HBOC.
Methods. We aimed to discover novel methylation marks associated with HBOC risk in 231 incident cases negative for pathogenic variants and 156 healthy controls using peripheral blood DNA, through methylation analysis by targeted bisulfite sequencing (NGS-Illumina) on 18 tumor suppressor gene promoters (330 CpG sites).
Results. Increased methylation levels were detected in the promoters of EPCAM (p=0.00088), ATM (p=0.0074), and RAD51C (p=0.018). Four specific sites were linked to an increased risk of HBOC, FANCI (cg89786999) OR:1.64 (95%CI:1.3-2.0), PALB2 (cg23652916) OR=1.65 (95%CI:1.4-1.9), MSH2 (cg47630224) OR:1.93 (95%CI:1.5-2.4), and EPCAM (cg47596828) OR= 2.93 (95%CI:2.1-4.1). The biomarker capacity of the four sites showed an area under the curve (AUC) of 0.758, high specificity and sensitivity. Comparison with three well-established cohorts revealed that MSH2 cg47630224 methylation was associated with 3-fold increased HBOC risk (AUC: 0.892, sensitivity: 0.90, specificity: 0.89).
Conclusions. Four novel DNA methylation CpG sites were associated with HBOC risk, suggesting potential application as biomarkers in patients without detectable coding mutations.
Restored oxbow wetlands within an agricultural landscape: using physical and biological characteristics to evaluate impacts of tile drainage input
Authors: Leberg Samuel , Osterhaus Dylan , Pierce Clay , Stewart Timothy
Published: September 2023

Oxbow wetlands have been restored in the Midwestern United States to sequester sediment and nutrients originating from agricultural activities and to provide habitat for wetland-dependent species. Intensive agriculture may have adverse impacts on oxbow functions, especially if wetlands receive water inputs from subsurface drainage systems (e.g., tile drainage). To explore the influence of tile drainage on oxbow wetland ecology, we quantified relationships between physical and biotic variables in 12 Iowa, USA oxbows over a two-year period. Six oxbows received direct water inputs from tile drainage (multipurpose oxbows), whereas remaining sites did not (non-tiled oxbows). In each oxbow, we measured physical variables and documented taxonomic composition, diversity, and abundance of macrophytes, macroinvertebrates, and fishes. Although water temperature was lower in multipurpose oxbows, values for remaining physical variables were similar across sites. No significant difference was detected for any biotic variable across oxbow type. Across field seasons, 44 invertebrate taxa were observed in both oxbow types with an average richness of 18.6 in non-tiled oxbows and 17.5 in tile-fed oxbows. We sampled 35 fish species, with an average richness of 8.2 in non-tiled oxbows and 11.4 in multipurpose oxbows. A total of 2682 Topeka shiner were found in both non-tiled and multipurpose oxbows. Non-metric multidimensional scaling revealed that potential physical determinants of macrophyte, invertebrate, and fish abundance were unrelated to tile drainage. Our results suggest that tile drainage has negligible ecological impact on multipurpose oxbows in agricultural landscapes and does not cause physical or biological characteristics to differ significantly between oxbow types.