bluuebunny/crossref_metadata_2025 huggingface dataset:
The Embryotoxicity of Alpha-Pinene to the Early Life Stages of Zebrafish (Danio Rerio Hamilton, 1822)
Authors:   Department of Molecular Biology and Genetics, Faculty of Science, Atatürk University, Erzurum 25240, Turkey., Şişman Turgay , Ceylan Zeynep ,   Department of Environmental Engineering, Faculty of Engineering, Atatürk University, Erzurum 25240, Turkey
Published: April 2023

The Alpha-pinene (AP) is produced by pine trees and other plants. The AP exhibits various biological activities such as the development of antimicrobial and antiviral agents, flavors, fragrances, and fungicidal agents. The toxicity data for AP are limited. This study aimed to determine the embryotoxic effects of AP in zebrafish embryos. 1.5 hpf zebrafish embryos were exposed to different concentrations of AP for 72 hours. The LC50 and EC50 values for AP were determined as 441.360 mg/L and 367.795 mg/L, respectively. The embryos were not much affected by AP until hatching. In addition, AP showed teratogenic effects at high doses (320 and 640 mg/L). Typical lesions were an absence of somite (≤48 hpf), lordosis, yolk sac deformity, tail abnormality, cardiac edema, and eye shrinkage (≤ 72 hpf). However, survival rates of zebrafish embryos in the 20, 40, and 80 mg/L AP groups were greater than 80 % during the exposure period. Very low teratogenicity for zebrafish embryos was observed in the 160 mg/L AP group. The results show virtually no embryotoxicity and teratogenicity at 20 and 40 mg/L AP concentrations. No delay in developmental was also observed. Therefore, AP can be considered a safe compound in the concentrations. Keywords: Alpha-pinene, Embryotoxicity, EC50, LC50, Zebrafish
Effects of Biochar and Poultry Manure Amendments on Soil Physical and Chemical Properties, Growth and Sweet Potato Yield in Degraded Alfisols of Humid Tropics
Authors:   Department of Agronomy, Adekunle Ajasin University, P.M.B. 001, Akungba-Akoko, Ondo State, Nigeria, Agbede Taiwo Michael ,   Department of Crop, Soil and Pest Management Technology, Rufus Giwa Polytechnic, P.M.B. 1019, Owo, Ondo State, Nigeria, Oyewumi Adefemi ,   Department of Agricultural Technology, Rufus Giwa Polytechnic, P.M.B. 1019, Owo, Ondo State, Nigeria
Published: April 2023

Information on the impact of biochar and poultry manure on soil characteristics and sweet potato productivity in the humid tropics is lacking. Hence, field experiments were conducted at two locations during the 2019 and 2020 cropping seasons to assess the effects of biochar (B), poultry manure (PM), and their mixture on soil physical and chemical properties, growth and tuber yield of sweet potato (Ipomoea batatas L.) Each year, the experiment consisted of 4 × 3 factorial combinations of biochar (0, 10.0, 20.0 and 30.0 t ha-1) and poultry manure (0, 5.0 and 10.0 t ha-1). The findings revealed that using B and PM alone, as well as in combination, improved soil physical and chemical qualities, as well as sweet potato performance. Significant interactions of B and PM (B × PM) were observed on soil characteristics and sweet potato variables that were measured in both years, showing B’s potential in enhancing PM use efficiency. Pooled over two years, application of the highest dosage of 30.0 t ha-1 B + 10.0 t ha-1 PM significantly increased tuber yield of sweet potato compared with other treatments. The multiple regressions showed that both soil physical (bulk density, porosity and moisture content) and chemical (pH, OC, TN, P, K, Ca, and Mg) properties had a significant impact on sweet potato leaf area and tuber yield. The findings indicated that B and PM have the ability to improve soil quality and sweet potato production. Keywords: Biochar; Poultry manure; Soil properties; Sweet potato; Alfisols
Effect of Long-term Ketogenic Diet on Serum Alanine Transaminase Levels in Mice (Mus musculus)
Authors:   Medical Programme, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia, Meiliana Ismi Dian , Rejeki Purwo Sri ,   Department of Physiology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia., Miftahussurur Muhammad ,   Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia,   Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia, Fasitasari Minidian ,   Department of Nutrition, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang 50112, Indonesia
Published: April 2023

The prevalence of obesity is increasing worldwide over the years. One of the non-pharmacological therapy which is believed to be promote weight loss is ketogenic diet. Nevertheless, the long-term effects which may be caused by this diet are still debating, especially in the liver. This study aimed to determine the effect of long-term ketogenic diet (8 weeks) on serum alanine transaminase (ALT) levels. Twelve male mice were divided into basal diet (BD) and ketogenic diet (KD) group and given intervention for eight weeks adlibitum. Body weight was weighed in pre and post-intervention, while ALT levels were measured only once after eight weeks of intervention. As a result, pre-intervention body weight in the BD group was 25.170 ± 2.858 g and KD group was 27.170 ± 1.329 g (P =0.151). In the post-intervention, body weight in BD and KD group were 44.500 ± 5.244 g and 31.830 ± 5.707 g, respectively (P =0.003). BD group showed a significant difference between pre-and post-intervention body weight (P <0.0001); however, it was not significant in the KD group (P =0.096). After eight weeks, serum ALT levels in BD-fed mice were 90.672 ± 20.786 U/L and in KD-fed mice showed 117.037 ± 19.261 U/L (P =0.046). In conclusion, KD elevated serum ALT levels and attenuated weight gain after 8-week KD supplementation. Keywords: Alanine transaminase, Ketogenic diet, Liver, Mice, Obesity
The Effects of Tok Sen Massage Menu for Relaxation on Muscle Flexibility and Relaxation among Use of Received the Lanna Spa Service for Health Tourism
Authors:   Faculty of Nursing, Chiang Mai University, Chiang Mai 50200, Thailand, Sansiriphun Nantaporn , Deeluea Jirawan ,   Faculty of Nursing, Chiang Mai University, Chiang Mai 50200, Thailand, Krikitrat Preeyakamon ,   Faculty of Nursing, Chiang Mai University, Chiang Mai 50200, Thailand, Klunklin Areewan ,   Panyapiwat Institute of Management, Nonthaburi 11120, Thailand
Published: April 2023

In spas in northern Thailand, Tok Sen massage is one aspect of the wisdom of health care in northern communities; it stimulates better functioning of blood circulation, the lymphatic system, and the nervous system, while helping to relieve pain, stiffness, and fatigue in various body parts, due to muscle flexibility and relaxation. This study aimed to examine the effects of Tok Sen massage for relaxation on muscle flexibility and relaxation. A randomized controlled trial enrolled 80 persons who met the inclusion criteria and were willing to participate in the Lanna Spa Service for Health Tourism between January and March 2022. They were randomly assigned to an experimental group (n=40) who received the Tok Sen massage for relaxation, and a control group (n=40) who were instructed to lie down in a comfortable environment without receiving a massage. Data were collected using a demographic form, a muscle flexibility record form, a relaxation assessment form, an automatic blood pressure and pulse monitor, a ruler, and the sit-and-reach tester. Demographic data were analyzed using descriptive statistics. Differences between groups were compared using Fisher's exact test, independent t-test, and the Mann-Whitney U test. The results showed that there was a statistically significant difference between the experimental group and the control group in the flexibility of the lower back muscles, hamstring muscles, hip muscles, shoulders, scapula, chest, and arm muscles (P < .01), and in relaxation (P < .001). The findings support the effectiveness of the Tok Sen massage menu on promoting muscle flexibility and relaxation. Keywords: Tok Sen massage, Muscle flexibility, Relaxation
Prediction of Outcome of Newly Onset Cerebrovascular Stroke in HCV Infected Patients
Authors: Atti Gadallah Abdelnaser Abdel , Abdelaziz Hany Abdelbary , Mousa Waleed Abdelfattah , Lashin Mohamed Elsaeed , Al-Abyad Mostafa Ahmed , Mohamed Anwar Abdelaleem
Published: April 2023

Chronic Vascular Diseases (CVD) is a major health burden. Hepatitis C Virus (HCV) infection has been implicated in the development of carotid artery atherosclerosis and has recently been associated with poor prognosis in stroke patients. The purpose of this study is to predict the result of de novo cerebrovascular accidents in HCV-infected patients and to look for variables that may predict it. Case control, prospective study had been carried out on two groups, Group (A) of 32 HCV infected patients presented with newly onset cerebrovascular stroke and Group (B) of 32 patients with cerebrovascular stroke without HCV infection. After meticulous history taking and neurological examination for all patients, those presenting with cerebrovascular stroke confirmed by computerized tomography (CT) or Magnetic resonance imaging (MRI) of brain were included in this study. These patients were followed up for 2 weeks and then extended follow up for 3 months was done. The outcome and predictors of prognosis had been documented and estimated statistically. Hb, platelets, albumin, cholesterol, and Na showed significant decreases in the HCV patients than in the free group. However, direct bilirubin, total bilirubin, international normalized ratio (INR), and HbA1C showed significant increases in the case group. Age, National institute of health stroke scale (NIHSS), and Diabetes Mellitus (DM) showed significant increases in poor prognosis in HCV cases, whereas HDL showed a significant decrease. NIHSS, abnormal carotid intima thickness (CIT), and abnormal pulse showed significant increases in control group with poor prognosis. Regarding fate, no significant difference was found between HCV patients and the control group. Regarding prognosis by three-month Modified rankin score (MRS) a significant decrease in the HCV patient group in comparison to the free group. We found there is a significant association between chronic HCV infections and Ischemic Stroke severity and bad prognosis.
Curcumin Alleviates Thioacetamide-Induced Kidney Toxicity in Rats: Enhancing Antioxidant System, and Attenuating Oxidative Stress, DNA Damage, and Inflammation
Authors: Radwan Aliaa M. , Karhib Mustafa , A. Fatoh Shahenda , Tousson Ehab
Published: April 2023

Thioacetamide (TAA), well-known as a toxic agent and has been reported to be nephrotoxic due to oxidative stress induction and proinflammatory markers increase. Curcumin has been shown in various studies to have antioxidant and anti-inflammatory properties. This study aimed to investigate the ameliorative effect of curcumin against TAA-induced kidney toxicity in rats. In this study, 28 male albino rats were used, and kidney toxicity was induced by intraperitoneal injection of TAA at a dose of 200mg/kg, twice a week for 8 weeks then the rats were treated with curcumin at a dose of 200mg/kg, orally, daily for 2 weeks. Kidney functions in all the experimental groups as well as oxidative stress (MDA), catalase (CAT), and superoxide dismutase (SOD) were determined. In addition, DNA damage and the expression status of both proinflammatory cytokine (TNFα) and proliferating cell nuclear antigen (PCNA) were evaluated. Further, light microscopic studies were performed on kidney specimens. Our results demonstrated that TAA had a nephrotoxic effect, as evidenced by significantly increase in kidney functions as well as substantially increase in renal MDA associated with reduction in CAT and SOD antioxidant enzymes compared to control group. The administration of curcumin ameliorates the oxidative stress and upregulate the antioxidant parameters. Further, a signification increases in DNA damage, TNFα, and PCNA expression was seen in TAA-group which was then alleviated by curcumin treatment. In conclusion, the ameliorative effect of curcumin could be attributed to its ability to minimize oxidative stress, renal cell injury, and cytokine release.
Overexpression of MicroRNA 21 in Cervical Carcinoma with Lymph Node Metastasis
Authors: NW Armerinayanti , IM Bakta , IG Alit Artha , IAI Wahyuniari , Widodo Samuel
Published: April 2023

Cervical carcinoma being the second common cancer in women in Indonesia, as well as in Bali, and mostly patients are diagnosed at an advanced stage with having metastases. The lymphatic pathway (lymph nodes) is the most frequent route for cervical cancer metastases. MicroRNA is a novel invention for predicting the biological behavior of cervical carcinoma and has the potential to act as the foundation for targeted therapy for cervical cancer. Several microRNA profiles, including microRNA 21, microRNA 126, and microRNA 143, were discovered to regulate the biological activity of cervical cancer. However, no studies have established a correlation between the expression of one of these microRNAs and the incidence of lymph node metastases in cervical cancer. This study aims to analyze whether overexpression of microRNA 21 is a risk factor for lymph node metastases in cervical cell carcinoma. Collected data was descriptively analyzed using the chi-square test with a p-value<0.05 and 95% CI. The results showed that microRNA 21 was significantly overexpressed in cervical carcinomas with lymph node metastases compared to those without lymph node metastases, representing a 19-fold increased risk for lymph node metastases. This can be influenced by the activity of microRNA 21 on several signaling pathways, such as Phosphatase and Tensin Homolog (PTEN), Programmed Cell Death Protein 4 (PDCD4), and Tissue inhibitor of metalloproteinase 3 (TIMP3), that affect the progression, invasion capacity, and metastasis of tumor cells.
Beam pattern control for graphene-based patch array antenna with radio-over-fiber systems by using modulation instability phenomenon
Authors: Azizpour Rasul , Zakeri Hassan , Moradi Gholamreza
Published: April 2023

This paper presents a beam control system for a graphene-based phased array antenna (PAA) using the proposed radio-over-fiber (RoF) in the THz and sub-THz bands. The generated pulses are modulated by the Mach-Zehnder modulator (MZM) and, by using the special design of the fiber under modulation instability (MI), can be amplified at the sideband of the carrier. Finally, changing the length of the compensating fiber in the bit-control system makes it possible to control the PAA beam pattern. Improving the bias voltage (V
π
) of the MZM, simplicity of the RoF system structure, and increasing the spontaneous gain caused by the MI phenomenon are the advantages of the proposed system. Therefore, it is an acceptable candidate for the beam control applications system. Also, the patch antenna is based on graphene and has a new structure. This antenna consists of radiation patches in an octagonal shape and a microstrip feed line. The antenna operates with appropriate radiation features, with gains of 12 dB and returns losses of less than -10 dB at 700 GHz bandwidth. All simulations are performed using the CST Microwave Studio and the Optiwave software.
Remote sensing of human skin temperature by AI speckle pattern analysis
Authors: Ben David Ofir , Beiderman Yevgeny , Agdarov Sergey , Beiderman Yafim , Zalevsky Zeev
Published: April 2023

Analysis of dynamic differential speckle patterns, scattered from human tissues illuminated by a laser beam, has been found by many researchers to be applicable for noncontact sensing of various biomedical parameters. The COVID-19 global pandemic brought the need for massive rapid-remote detection of a fever in closed public spaces. The existing non-contact temperature measurement methods have a significant tradeoff between the measurement distance and accuracy. This paper aims to prove the feasibility of an accurate temperature measurement system based on speckle patterns analysis, enabling the sensing of human temperature from an extended distance greater than allowed by the existing methods. In this study, we used speckle patterns analysis combined with artificial intelligence (AI) methods for human temperature extraction, starting with fever/no fever binary classification and continuing with temperature measurement at higher resolution.
Online learning of the transmission matrix of dynamic scattering media
Authors: Valzania Lorenzo , Gigan Sylvain
Published: April 2023

Following recent advancements in wavefront shaping, optical methods have proven crucial for imaging and light control in multiply scattering media, such as biological tissues. However, the stability times of living biological specimens often prevent such methods from providing insights into relevant functioning mechanisms in cellular and organ systems. Here, we present a recursive and online optimization routine, borrowed from time series analysis, to optimally track the transmission matrices of dynamic scattering media over arbitrarily long time scales. It operates in a memory-efficient manner while preserving the advantages of both optimization-based routines and transmission-matrix measurements. Because it can be readily implemented in existing wavefront shaping setups featuring amplitude and/or phase modulation and phase-resolved or intensity-only acquisition, it could enable efficient optical investigations of living biological specimens.
300  km ultralong fiber optic DAS system based on optimally designed bidirectional EDFA relays
Authors: Fan Cunzheng , Li Hao , Zhang Keqing , Liu Huanhuan , Sun Yixiang , Liu Haoguang , Yan Baoqiang , Yan Zhijun , Liu Deming , Shum Perry Ping , Sun Qizhen
Published: April 2023

Optical fiber distributed acoustic sensing (DAS) based on phase-sensitive optical time domain reflectometry (φ-OTDR) is in great demand in many long-distance application fields, such as railway and pipeline safety monitoring. However, the DAS measurement distance is limited by the transmission loss of optical fiber and ultralow backscattering power. In this paper, a DAS system based on multispan relay amplification is proposed, where the bidirectional erbium-doped fiber amplifier (EDFA) is designed as a relay module to amplify both the probe light and the backscattering light. In the theoretical noise model, the parameters of our system are carefully analyzed and optimized for a longer sensing distance, including the extinction ratio (ER), span number, span length, and gain of erbium-doped fiber amplifiers. The numerical simulation shows that a bidirectional EDFA relay DAS system can detect signals over 2500 km, as long as the span number is set to be more than 100. To verify the effectiveness of the scheme, a six-span coherent-detection-based DAS system with an optimal design was established, where the cascaded acoustic-optic modulators (AOMs) were used for a high ER of 104 dB. The results demonstrate that the signal at the far end of 300.2 km can be detected and recovered, achieving a high signal-to-noise ratio of 59.6 dB and a high strain resolution of 51.8pε/Hz at 50 Hz with a 20 m spatial resolution. This is, to the best of our knowledge, a superior DAS sensing distance with such a high strain resolution.
Identifizierung von Wertpotenzial für digitale Services von B2B-Fertigungsunternehmen am Beispiel eines Küchengeräteherstellers
Authors: Jonas Claudius , Watkowski Laura , Link Janina , Buck Christoph
Published: April 2023

Traditionelle Business-to-Business-Fertigungsunternehmen sehen sich einem wachsenden Bedarf an digitalen Services konfrontiert, die ihre physischen Produkte ergänzen. Da die meisten digitalen Services große Datenmengen generieren, bieten sie nicht nur wertvolles Potenzial für Kunden zur Unterstützung bei der Nutzung der digitalen Services, sondern auch für den Anbieter, um die Bedürfnisse und das Verhalten ihrer Kunden besser zu verstehen. Da sich die Wertschöpfungsmechanismen digitaler Services grundlegend von denen physischer Produkte unterscheiden, sind die Preisgestaltung und die Entwicklung nachhaltiger Geschäftsmodelle eine Herausforderung für produzierende Unternehmen. Es bedarf im Gegensatz zu einem kostenbasierten Preisansatz einer wertorientierten Preisgestaltung, wozu anfangs das Wertpotenzial eines digitalen Service erfasst werden muss. Anhand des Falls des Industrieküchengeräteherstellers Kitchenwise stellen wir einen methodischen Ansatz vor, wie Unternehmen digitale Serviceangebote identifizieren können, die das physische Produktportfolio ergänzen und dadurch von einer wertorientierten Preisgestaltung profitieren. So zeigen wir, wie Kitchenwise durch die Einbindung interner und externer Stakeholder eine angemessene und akzeptierte Preisspanne für seine digitalen Services definieren konnte.
Entwicklung und Evaluation einer gamifizierten Design Thinking Methode für die frühe Phase des Innovationsmanagements
Authors: Härer Florian , Herzwurm Georg
Published: April 2023

Das Innovationsmanagement wird für Unternehmen immer bedeutsamer und insbesondere die frühe Phase des Innovationsprozesses, welche aber aufgrund des volatilen Umfeld einige Herausforderungen besitzt. Der folgende gestalterische Forschungsbeitrag versucht diese Probleme aufzugreifen und mittels eines situativen Theorieansatzes zu lösen. Dafür wurde durch den Aspekt von Gamification eine neue Methode auf der Grundlage von Design Thinking systematisch und wissenschaftlich konstruiert. In einer Einzelfallstudie aus der Automobilbranche konnten durch drei verschiedene Durchläufe die neue Methode im Feld angewendet und mit den teilnehmenden Personen evaluiert werden. Die Ergebnisse zeigen einerseits auf, dass die neue Methode für die Entwicklung von Ideen genutzt werden kann und einige identifizierte Gestaltungsprobleme gelöst werden konnten. Andererseits, besitzt die Methode aber weiteren Forschungsbedarf, um die Qualität der frühen Phase des Innovationsprozesses noch weiter zu verbessern.
Control of stereocilia length during development of hair bundles
Authors: Krey Jocelyn F. , Chatterjee Paroma , Halford Julia , Cunningham Christopher L. , Perrin Benjamin J. , Barr-Gillespie Peter G.
Published: April 2023

Assembly of the hair bundle, the sensory organelle of the inner ear, depends on differential growth of actin-based stereocilia. Separate rows of stereocilia, labeled 1 through 3 from tallest to shortest, lengthen or shorten during discrete time intervals during development. We used lattice structured illumination microscopy and surface rendering to measure dimensions of stereocilia from mouse apical inner hair cells during early postnatal development; these measurements revealed a sharp transition at postnatal day 8 between stage III (row 1 and 2 widening; row 2 shortening) and stage IV (final row 1 lengthening and widening). Tip proteins that determine row 1 lengthening did not accumulate simultaneously during stages III and IV; while the actin-bundling protein EPS8 peaked at the end of stage III, GNAI3 peaked several days later—in early stage IV—and GPSM2 peaked near the end of stage IV. To establish the contributions of key macromolecular assemblies to bundle structure, we examined mouse mutants that eliminated tip links (Cdh23v2JorPcdh15av3J), transduction channels (TmieKO), or the row 1 tip complex (Myo15ash2).Cdh23v2J/v2JandPcdh15av3J/av3Jbundles had adjacent stereocilia in the same row that were not matched in length, revealing that a major role of these cadherins is to synchronize lengths of side-by-side stereocilia. Use of the tip-link mutants also allowed us to distinguish the role of transduction from effects of transduction proteins themselves. While levels of GNAI3 and GPSM2, which stimulate stereocilia elongation, were greatly attenuated at the tips ofTmieKO/KOrow 1 stereocilia, they accumulated normally inCdh23v2J/v2JandPcdh15av3J/av3Jstereocilia. These results reinforced the suggestion that the transduction proteins themselves facilitate localization of proteins in the row 1 complex. By contrast, EPS8 concentrates at tips of allTmieKO/KO,Cdh23v2J/v2J, andPcdh15av3J/av3Jstereocilia, correlating with the less polarized distribution of stereocilia lengths in these bundles. These latter results indicated that in wild-type hair cells, the transduction complex prevents accumulation of EPS8 at the tips of shorter stereocilia, causing them to shrink (rows 2 and 3) or disappear (row 4 and microvilli). Reduced rhodamine-actin labeling at row 2 stereocilia tips of tip-link and transduction mutants suggests that transduction’s role is to destabilize actin filaments there. These results suggest that regulation of stereocilia length occurs through EPS8 and that CDH23 and PCDH15 regulate stereocilia lengthening beyond their role in gating mechanotransduction channels.
Shortcomings of reusing species interaction networks created by different sets of researchers
Authors: Brimacombe Chris , Bodner Korryn , Michalska-Smith Matthew , Poisot Timothée , Fortin Marie-Josée
Published: April 2023

Given the requisite cost associated with observing species interactions, ecologists often reuse species interaction networks created by different sets of researchers to test their hypotheses regarding how ecological processes drive network topology. Yet, topological properties identified across these networks may not be sufficiently attributable to ecological processes alone as often assumed. Instead, much of the totality of topological differences between networks—topological heterogeneity—could be due to variations in research designs and approaches that different researchers use to create each species interaction network. To evaluate the degree to which this topological heterogeneity is present in available ecological networks, we first compared the amount of topological heterogeneity across 723 species interaction networks created by different sets of researchers with the amount quantified from non-ecological networks known to be constructed following more consistent approaches. Then, to further test whether the topological heterogeneity was due to differences in study designs, and not only to inherent variation within ecological networks, we compared the amount of topological heterogeneity between species interaction networks created by the same sets of researchers (i.e., networks from the same publication) with the amount quantified between networks that were each from a unique publication source. We found that species interaction networks are highly topologically heterogeneous: while species interaction networks from the same publication are much more topologically similar to each other than interaction networks that are from a unique publication, they still show at least twice as much heterogeneity as any category of non-ecological networks that we tested. Altogether, our findings suggest that extra care is necessary to effectively analyze species interaction networks created by different researchers, perhaps by controlling for the publication source of each network.
Spatio-temporal six-year retrospective study on dermatophytosis in Rio de Janeiro, Southeast Brazil: A tropical tourist locality tale
Authors: Brito Simone Cristina Pereira , Pinto Márcia Ribeiro , Alcântara Lucas Martins , Reis Nathália Faria , Durães Thiago Lacerda , Bittar Christina Teresa Machado , de Oliveira Jeferson Carvalhaes , da Rocha Elisabeth Martins da Silva , Dantas Machado Ricardo Luiz , Souza e Guimarães Ricardo José de Paula , Baptista Andréa Regina de Souza
Published: April 2023

Trichophyton,Microsporum,NannizziaandEpidermophytongenera cause dermatophytosis, the most common and highly contagious infectious skin disease. Rio de Janeiro is one of the most visited cities in the Southern Hemisphere, located in the most visited state of Brazil. This retrospective study investigated epidemiological and laboratorial aspects of dermatophytosis in Rio de Janeiro state, Brazil, by using spatiotemporal analysis. More than half of all individuals were infected by one or more dermatophytes. A variation between 18 and 106 years-old of the studied population was verified, and women more frequently affected. Patients were more frequently infected byTrichophytonspp., most of themT.rubrum, followed byT.mentagrophytes.M.canisandN.gypseawere more frequently isolated in the age group between 40 and 60 years old, whileT.rubrumpredominates among younger patients. All species presented homogeneous distribution whileT.tonsuransappears to be restricted to the Rio de Janeiro capital andE.floccosumto the municipality of Macaé (190 Km apart from RJ). Rio de Janeiro state presented spatial clusters of dermatophytosis with high density in Guanabara Bay (E.floccosum,M.canis,N.gypsea,T.tonsurans) and Niterói (T.rubrum,T.mentagrophytes) but low density in Macaé (E.floccosum). Significant spatiotemporal clusters on dermatophytosis cases were detected in distinct municipalities (p-value ≤ 0.05). The Vulnerability Index (r = 0.293) and Demographic Density (r = 0.652) distributed according to neighborhoods in Niterói were direct related with dermatophytosis cases whereas Income (r = -0.306) was inversely correlated (p-value ≤ 0.05). The dermatophytosis spatiotemporal distinct distribution after two major international events in Rio de Janeiro, Brazil, highlight the pressing need for specific measures of its prevention and controlling. This is particularly relevant in touristic tropical localities which must consider both socio-economical and traveler’s medicine variables.
Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
Authors: Bressan Clarisse da Silveira , Teixeira Maria de Lourdes Benamor , Gouvêa Maria Isabel Fragoso da Silveira , de Pina-Costa Anielle , Santos Heloísa Ferreira Pinto , Calvet Guilherme Amaral , Lupi Otilia , Siqueira Andre Machado , Valls-de-Souza Rogério , Valim Clarissa , Brasil Patrícia
Published: April 2023

Introduction

Acute febrile illnesses (AFI) are a frequent chief complaint in outpatients. Because the capacity to investigate the causative pathogen of AFIs is limited in low- and middle-income countries, patient management may be suboptimal. Understanding the distribution of causes of AFI can improve patient outcomes. This study aims to describe the most common etiologies diagnosed over a 16-years period in a national reference center for tropical diseases in a large urban center in Rio de Janeiro, Brazil.

Methods

From August 2004-December 2019, 3591 patients > 12 years old, with AFI and/or rash were eligible. Complementary exams for etiological investigation were requested using syndromic classification as a decision guide. Results. Among the 3591 patients included, endemic arboviruses such as chikungunya (21%), dengue (15%) and zika (6%) were the most common laboratory-confirmed diagnosis, together with travel-related malaria (11%). Clinical presumptive diagnosis lacked sensitivity for emerging diseases such as zika (31%). Rickettsia disease and leptospirosis were rarely investigated and an infrequent finding when based purely on clinical features. Respiratory symptoms increased the odds for the diagnostic remaining inconclusive.

Conclusions

Numerous patients did not have a conclusive etiologic diagnosis. Since syndromic classification used for standardization of etiological investigation and presumptive clinical diagnosis had moderate accuracy, it is necessary to incorporate new diagnostic technologies to improve diagnostic accuracy and surveillance capacity.
Water sources and composition of dissolved gases and bubbles in a saline high Arctic spring
Authors: Andersen Dale T. , McKay Christopher P. , Pollard Wayne H. , Marinova Margarita M.
Published: April 2023

We investigate the water sources for a perennial spring, “Little Black Pond,” located at Expedition Fiord, Axel Heiberg Island in the Canadian High Arctic based on dissolved gases. We measured the dissolved O2 in the likely sources Phantom Lake and Astro Lake and the composition of noble gases (3He/4He, 4He, Ne,36Ar, 40Ar, Kr, Xe), N2, O2, CO2, H2S, CH4, and tritium dissolved in the outflow water and bubbles emanating from the spring. The spring is associated with gypsum-anhydrite piercement structures and occurs in a region of thick, continuous permafrost (400–600 m). The water columns in Phantom and Astro lakes are uniform and saturated with O2. The high salinity of the water emanating from the spring, about twice sea water, affects the gas solubility. Oxygen in the water and bubbles is below the detection limit. The N2/Ar ratio in the bubbles and the salty water is 89.9 and 40, respectively, and the relative ratios of the noble gases, with the exception of Neon, are consistent with air dissolved in lake water mixed with air trapped in glacier bubbles as the source of the gases. The Ne/Ar ratio is ~62% of the air value. Our results indicate that about half (0.47±0.1) of the spring water derives from the lakes and the other half from subglacial melt. The tritium and helium results indicate that the groundwater residence time is over 70 years and could be thousands of years.
How do caves breathe: The airflow patterns in karst underground
Authors: Gabrovšek Franci
Published: April 2023

Caves and their surrounding fracture systems in the vadose zone of karst regions host a unique atmospheric environment. Understanding the airflow patterns in caves is critical to understanding the properties of the subsurface atmosphere and the chemical interactions between air, water, and rock. The most common driver of airflow in caves is the density difference between the subsurface and the outside air, known as the chimney effect. Observations show that seasonal airflow patterns in caves also depend on the geometry of passages. In this work, I present and use a numerical model of a passage embedded and thermally coupled to a rock mass to study the relationship between the airflow pattern and passage geometry. As the outside air enters the subsurface, it approaches thermal equilibrium with the rock mass along a characteristic relaxation length. This determines the temperature and density contrast between the inside and outside air, and the resulting pressure difference, which drives the airflow. In passages with non-uniform outlines and/or cross-sections, the relaxation length may depend on the flow direction, resulting in different airflow velocities in cold and warm periods for the same absolute temperature difference between the massif and the external temperature. In a passage with a V-shaped longitudinal profile, the airflow is triggered by instability which causes the feedback between the relaxation length and airflow velocity. The airflow pattern can also be altered by snow and ice. Heat transfer in the rock and the thermal inertia of the rock also change the relaxation lengths and cause hysteresis in the curve presenting the airflow velocity vs. temperature difference.
experiência do “Águas de menino”:
Authors: Silva Renata de Lima , Falcão José Luiz Cirqueira
Published: April 2023

Neste artigo, tratamos das experiências pedagógicas comunitárias desenvolvidas nos anos 2018 e 2019 no projeto “Águas de Menino”, situado na região norte de Goiânia, Goiás. A Capoeira Angola constitui a temática central do projeto, a partir da qual são problematizadas questões étnico-raciais, intergeracionais, de classe e de gênero. “Fundo de quintal” constitui uma metáfora que implica a existência de um espaço físico e simbólico que viabiliza a experiência comunitária por intermédio de processos de compartilhamento de saberes. O projeto vem se concretizando como espaço de afirmação identitária, de politização e de colaboração em que os fundamentos da Capoeira Angola e de outras manifestações afro-brasileiras são vivenciadas numa dimensão popular, em que pensamento, sentimento e ação se interpenetram assentados num contexto de valorização da ancestralidade, da corporeidade, da oralidade, da afetividade, da vivacidade cultural e da justiça sociocognitiva. Com isso, a ação do “Águas de Menino” pode ser compreendida como uma possibilidade de enfrentamento à colonialidade do saber e se instaura como uma proposta de educação de fundo de quintal que atua em uma perspectiva decolonial.
Narrativas de estudos sobre o campo aditivo na extensão universitária
Authors: Leite Vania Finholdt Angelo , Trotte Leticia Pacheco de Mello , Martins Fernanda Medeiros Alves Besouchet
Published: April 2023

O texto analisa os registros dos participantes de um curso de extensão, realizado em uma universidade pública, identificando o que os estudantes aprenderam durante o curso com a seguinte questão: Quais são os saberes pedagógicos apontados pelos participantes nos registros do seu processo de aprendizagem? Apoiamo-nos na teoria dos Campos Conceituais de Vergnaud (1990) e em Smole (2007) com a proposta de discutir e analisar situações de aprendizagem cujas estruturas encontram-se no campo aditivo. Tivemos como público-alvo: os graduandos de Pedagogia, professores da Educação Infantil, do Ensino Fundamental e Coordenadores Pedagógicos. Esse curso foi proposto pela demanda apontada pelos participantes de uma atividade de extensão que acontece uma vez por mês na universidade. Eles solicitaram do nosso grupo de pesquisa a realização de um curso de extensão com essa temática. Notamos que eles se apropriaram do planejamento, do papel do professor como mediador, organizador de situações e intervenções que proporcionem a aprendizagem da criança. Além desses, o mais significativo é o fato de ressignificarem sua relação com a matemática. Isso é fundamental para que possam ensiná-la planejando aulas mais significativas, considerando os conhecimentos, saberes e não saberes de seus alunos.
Fasilitas Pejalan Kaki bagi Penyandang Disabilitas pada Jalur Pedestrian di Lapangan Merdeka Kota Bengkulu
Authors: Dwi Oktavallyan Saputri
Published: April 2023

Jalur Pedestrian Lapangan Merdeka Kota Bengkulu merupakan salah satu salah satu elemen ruang publik yang yang semestinya mampu memberikan rasa kenyamanan, keamanan, dan kemudahan bagi semua orang, termasuk para penyandang disabilitas.. Maka diperlukan studi dan analisis mengenai kondisi jalur pedestrian taman kota Lapangan Merdeka khususnya bagi pengguna disabilitas. Penelitian akan dilakukan dengan pengamatan langsung pada objek penelitian, yaitu jalur pedestrian Lapangan Merdeka Bengkulu, dengan pendataan dan analisa terhadap variabel fasilitas pedestrian baik ukuran, permukaan, area istirahat, pencahayaan, drainase, ram, tangga, dan rambu/marka. Hasil yang didapatkan bahwa jalur pedestrian Lapangan Merdeka Kota Bengkulu, terkait fasilitas bagi penyandang disabilitas masih memiliki beberapa kekurangan baik dari kualitas maupun keberagaman. Sehingga jalur pedestrian Lapangan Merdeka Kota Bengkulu belum sepenuhnya ramah terhadap penyandang disabilitas. Perlu dilakukannya evaluasi lebih lanjut oleh pemegang wewenang terhadap jalur pedestrian agar dapat digunakan semua kalangan, baik pengguna anak-anak, lansia, maupun penyandang disabilitas.
Kajian Ruang Kepegawaian Di Gedung Komisi Nasional Disabilitas Dalam Konsep Desain Inklusif
Authors: Harahap Rachmita Maun , Permatasasi Chandrarezky , Hayati Arina , Bararatin Kirami
Published: April 2023

The purpose of the study is to identify the design aspects of working environment based on the experience of people with disability. The first floor of Komisi Nasional Disabilitas (KND) workspace which used by National Commission for Disabilities as its secretariat, will be the priority case of this study. The study examine how to implement the inclusive design concept in the workplace focus on realizing equal opportunities in the implementation of Respect, Protection and Fulfillment of the Rights of Persons with Disabilities. The research use qualitative approach, include the use of methods such as in-depth interviews, participant observation, architectural and interior elements’ measurement based on Universal Design and Deaf Space principles. Quantitative approach is also applied by using questioners’ assessment for measuring values of environment by way of comparison with the regulations of Universal Design and Deaf Space guidelines. The results shows that personal experience of people with disability plays important role to evaluate their environment. The meaning of inclusive and accessible environment can be vary based on the participants’ interpretation. Yet during the participant observation, the study reveals that the building and interior spaces of KND have not been designed to meet the principles of universal design and deaf space. The participants mostly have done some physical adjustment and spatial/furniture arrangements to meet their personal conditions, needs, and preference to carry out their daily activities independently.  In conclusion, this research proposes design parameters from the perspective of the participants elaborated with the principles Universal design and Deaf Space in effort to increase inclusivity for all users.
Multilingualism and Indigenous School Education in Brazil: past, present and future challenges
Authors:   Universidad de Cádiz, de Oliveira Carolina Miranda , Figueira-Cardoso Samuel ,   University of Warsaw
Published: April 2023

In Brazil, only with the Federal Constitution of 1988 is indigenous peoples guaranteed the right to use their languages and cultures. However, since colonization, many languages have disappeared. The number of speakers of these languages has decreased, and different stages and language policies have promoted the Portuguese language at the expense of indigenous languages. All these factors to different sociolinguistic situations, current challenges in language teaching and learning, as scenarios of monolingualism in an indigenous language, continuum bilingualism, and non-speaking communities of an indigenous language. However, with revitalization, actions occur in the Brazilian context. We resorted to assumptions derived from studies on multilingualism, language policy, and language pedagogies. Based on these assumptions, this article aims to reflect on the moments and movements of indigenous school education and language policies in Brazil’s multilingual and multicultural country. This study is qualitative interpretive research based on a literature review in an integrative approach of theoretical perspectives concerned with the topic.
We look past that’: Linguistic repertoires and ideologies of Business Studies teachers at a South African High School
Authors:   Stellenbosch University, Oostendorp Marcelyn , Williams van Zyl Sasha
Published: April 2023

This paper reports on the linguistic repertoires and language ideologies of a small group of Business Studies teachers at a high school in Cape Town, South Africa. Using language portraits and focus group interviews to collect data, we found through a thematic analysis that teachers talked about their own repertoires as performative, playful, and innovative. By contrast, the repertoires of their students are not described in the same manner. Instead, the teachers either erase big parts of their students’ linguistic repertoires or see “accents” and African languages as deficient. African languages are seen as not suitable to use as a language of teaching and learning and is constructed as hampering rather than facilitating educational progress. We use the notion of chronotope to explain how the school as an institution shapes the different narratives evoked around repertoires. Finally, we discuss the implications of our findings for teacher pedagogy.
Two Endovascular Stent Graft Repairs Needed for an Extrathoracic Aortic Graft: Distant Complications After an Original Open Repair for a Gunshot Wound to the Chest
Authors: Kiely Kate , Arko Frank
Published: April 2023

Although the management of traumatic injuries to the thoracic aorta has shifted toward endovascular management, the historical standard of care is open reconstruction. Choosing to reoperate when faced with a complication from a prior open repair can be challenging; endovascular management can be a reasonable option in this situation. This report describes a 54-year-old man with a remote history of open surgery for a traumatic injury to the descending thoracic aorta who underwent endovascular aortic stent graft placement for coverage of extrathoracic graft extension with pseudoaneurysm formation and distal embolization. He returned a year later with a type IIIb endoleak with rupture into the posterolateral chest wall. A sec ond endovascular approach was used to successfully reline the graft and exclude the rupture.
The Foreign Trade Factor of the Force Majeure Economy: A Spatial Manoeuvre
Authors:   Economic Research Institute FEB RAS, Minakir Pavel
Published: April 2023

This paper considers the role of foreign trade interactions in forming a new macroeconomic equilibrium and equilibrium in the commodity market in the context of massive sanctions. The author analyzes the relations between the tools and conditions for maintaining foreign trade dynamics, and the role and proportion of traditional and new commodity markets in adapting to sanctions regimes. It is shown that in 2022 the spatial reformatting of foreign markets for Russian importers and exporters was more characteristic of import supplies. It is concluded that amid extraordinary financial and economic turmoil of 2022, which suddenly hit not only the Russian economy, but the entire global economy, the Russian economic system, for all its losses, held on to acceptable parameters, and foreign trade played an important role in this. It was determined that the instruments used in 2022 to reformat the spatial structure of markets could be substantially weakened over a long period
Human Capital of Rural Regions of Modern China
Authors:   Saint-Petersburg State University, Petrov Alexander , Zhi Jingkai ,   Saint-Petersburg State University, Baynova Maria ,   Moscow Financial and Industrial University ‘Synergy’, Petrova Ariadna ,   Institute of History, Saint-Petersburg State University
Published: April 2023

The purpose of the article is to analyze the results of actual theoretical and empirical studies of the process of accumulation of human capital in rural regions of China at the present stage of economic development. The PRC is still a country with a large proportion of the population living and working in rural regions. That is why the sustainability of the development of these regions and the country’s economy as a whole is largely determined by the peculiarities of the development of the labor resources of Chinese villages. The process of accumulation of human capital in rural regions plays an important role in China’s economic and social policy, as well as in solving the problem of ‘sannun’. The process of accumulation of human capital is influenced by three groups of interrelated factors: urbanization with Chinese characteristics, the level and quality of life, infrastructure and socio-institutional environment. The results of a comprehensive analysis of the influence of these groups of factors led to the conclusion that an elementary increase in public investment in the agricultural sector and rural regions of the PRC against the background of the development of free market relations, urbanization and income differentiation is not enough to ensure conditions for sustainable economic development and solving this problem. The role of human capital in the development of rural regions of China will increase only with the provision of opportunities to create an effective infrastructure and a favorable socio-institutional environment for its accumulation