bluuebunny/crossref_metadata_2025 huggingface dataset:
Reuse of stone working enterprise slurry in geopolymer and concrete products
Authors: Shamrai Volodymyr , Leonets Iryna , Melnyk-Shamrai Viktoriia , Patseva Iryna , Naumov Yaroslav
Published: December 2024

Purpose is to assess influence by fine stone working refuse (FSWR) on physicomechanical characteristics of geopolymer and concrete materials for future development of efficient methods of the FSWR reuse.

Methods. Geopolymer mixtures and concrete samples differing in FSWR proportions were applied for the research. Mechanical compression testing was performed with the samples, which helped assess influence by different number of FSWR on material strength. Totally, 16 polymer and 18 concrete samples were prepared.

Findings. The research has analyzed the possibility of FSWR application while manufacturing concrete and geopolymer materials to reuse industrial waste, and mitigate its environmental impact. The research is intended to identify FSWR effect on physicomechanical characteristics of materials, and develop techniques for their reuse. FSWR addition loses geopolymer strength: if content is 25% then strength is 20 MPa; if the content is 50% then strength drops down to 5.3 MPa. As for concrete, partial sand replacement by FSWR decreases strength insignificantly (from 37.42 to 36.6 MPa if FSWR content is 20%). Geopolymers with 25% of FSWR are suitable for low-load structures; in turn, concrete mixtures containing FSWR can be applied without significant strength decrease.

Originality. . For the first time, optimal fine refuse concentration of strong natural stone from Zhytomyr Region has been identified. The concentration is up to 25%. It provides acceptable compression strength with no significant decrease in technical characteristics.

Practical implications are as follows. Compliance with optimal FSWR proportions in composition of geopolymer and concrete mixtures makes it possible to reduce cost of raw materials; decrease FSWR amount; and support the closed economy principles in the construction industry.
On the use of remote sensing data to study the geological structure and forecast mineral resources of the Shu-Ile suture
Authors: Baibatsha Adilkhan , Vyazovetsky Yuriy , Kembayev Maxat , Rais Sayat , Agaliyeva Bakytgul
Published: December 2024

Purpose. This article focuses on analyzing the geodynamic processes that underline the formation of the Shu-Ile ore zone. The study is based on the principles of plume tectonics, which have gained widespread recognition in the geological community in recent decades.

Methods. The article considers the main aspects of the plume-tectonic concept, including the mechanisms of mantle material flows and their impact on regional geological processes. Special attention is paid to analyzing tectonic and magmatic events associated with forming the Shu-Ile ore zone within plume-tectonic mechanisms.

Findings. The study highlights the critical role of mantle plumes in influencing the geodynamic evolution of the Shu-Ile ore zone. Geochemical and geophysical evidence reveals the composition and characteristics of magmatic rocks, demonstrated a direct link between mantle plume processes and ore potential in the region. The findings underscore how mantle-derived material flows have significantly contributed to the formation of geological structures and mineral resources.

Originality. The study results offer a new perspective on the geological history of the Shu-Ile ore zone, emphasizing the significance of plume tectonics as a critical factor in the geodynamic processes involved in ore deposit formation.

Practical implications. This research is practical for geological studies and forecasting promising ore deposits in this region. It may serve as a basis for further research on plume tectonics and its influence on forming geological structures and mineral resources.
Evaluation of sugarcane clones for high yield and good ratooning ability for east coast zone of India
Authors: Ganapathy Subbarayan , Ravichandran Venugapal
Published: December 2024

The present investigation was undertaken with the objective of evaluation and identification of sugarcane clones for high yield, quality and its contributing traits in plant and ratoon crops. The study consists of three evaluation trials viz., Advanced Varietal Trial- plant-I (AVT-I), Advanced Varietal Trial-Plant-II (AVT-II) and AVT- Ratoon. All the three experiments consists of five test clones viz., CoA 12321, CoA 12322, CoA 12323, CoOr 12456 and CoV 12356 and three standards (Co 6907, CoC 01061, CoA 92081). Observations were recorded for number of tillers (x1000/ha), number of millable cane (x1000/ha), stalk length (cm), stalk diameter (cm), single cane weight (kg), cane yield (t/ha), brix (%), purity (%), sucrose (%), CCS (%) and CCS yield (t/ha). The results revealed that, among the test clones CoA 12322 and CoA 12321 registered the higher cane yield and CCS yield. The clone CoV 12356 recorded better performance for quality traits viz., sucrose per cent, purity per cent and CCS per cent.  Hence these three clones may be promoted for further evaluation trial and could be released as new sugarcane variety suitable for east coast zone of India.
Bangladesh J. Bot. 53(4): 1001-1009, 2024 (December)
Preparation, Characterization and In vitro Evaluation of Solid Dispersion Formulation of Clopidogrel Using Hydrophilic Polymers
Authors: Hossain ASM Monjur Al , Koly Fahima Jannat , Roy Sajib Chandra , Kumar Uttom , Hasanuzzaman Md , Islam Dipa
Published: December 2024

Clopidogrel bisulfate is a BCS class II drug with low water solubility leading to problematic dissolution behavior for oral drug delivery. The solid dispersion method was used to investigate the improvement of the dissolution profile of clopidogrel. Solid dispersions of clopidogrel were formulated using two polymers, PEG 6000 and poloxamer 188, at varying ratios through physical mixing and solvent evaporation techniques. A low-cost UV-Vis spectroscopic analytical method was developed at a λmax of 219 nm and validated following ICH guidelines. The dissolution of clopidogrel from solid dispersion improved significantly compared to pure drug, fitting most of the kinetics into the Korsmeyer-Peppas model. Comparisons showed that the binary solid dispersion formulation with clopidogrel: poloxmaer 188 at a ratio of 1:5 made via solvent evaporation method had the highest drug dissolution of 90.38% after 60 minutes, whereas the dissolution of pure clopidogrel was only about 66.67% in HCl media at pH 2. Characterization of prepared solid dispersions using FTIR, DSC, TGA and SEM confirmed the conversion of clopidogrel from crystalline to amorphous form.
Dhaka Univ. J. Pharm. Sci. 23(2): 123-134, 2024 (December)
Development of a Sustained-Release Oral Tablet of Tyrosine Kinase Inhibitor Imatinib Using Full Factorial Design
Authors: Faruk Omar , Shill Diponkor Kumar , Hossain A S M Monjur Al , Rouf Abu Shara Shamsur , Kumar Uttom
Published: December 2024

Tyrosine kinase inhibitors (TKIs) have dramatically improved the outcomes for patients with leukemia. The conventional immediate-release tablets of imatinib exhibit fluctuating plasma levels. The aim of this study was to develop sustained-release tablets of imatinib to maintain a steadier plasma drug concentration. A 32 fullfactorial design was used for the formulation optimization. The percentages of povidone K30 and methocel K15M were selected as independent variables and drug released after 24h in pH 6.8 phosphate buffer was chosen as a response. Statistical analysis of the response followed by empirical evaluation identified an optimum formulation that involved the use of 1.2% of povidone K30 and 3% of methocel K15M. The optimized formulation released 99.38% of the drug in vitro at pH 6.8 phosphate buffer after 24 hours, with an error of -0.353% to the predicted response and followed first-order release kinetics. The findings of this study enabled us to propose a new imatinib tablet dosage form for a more effective and patient-compliant leukemia therapy.
Dhaka Univ. J. Pharm. Sci. 23(2): 135-143, 2024 (December)
Evaluation of in vitro Cytotoxic and Anticancer Activities of Selected Plant Extracts Growing in Bangladesh
Authors: Suchana Lutfunnahar , Rahman M Oliur , Rashid Mohammad A , Sultan Md Zakir , Hassan Md Abul
Published: December 2024

Abstract not available
Dhaka Univ. J. Pharm. Sci. 23(2): 201-204, 2024 (December)
World Hypertension Day 2024 and unveiling the hidden challenge: Endocrine hypertension
Authors: Fariduddin Md
Published: December 2024

Abstract not available
J Assoc Clin Endocrinol Diabetol Bangladesh, July 2023;3(2): 38-39
Spontaneous hypoglycemia: A narrative review
Authors: Rahman Md Ashiqur , Islam Md Hasanul , Khan Murshed Ahamed , Fariduddin Md
Published: December 2024

Hypoglycemia is a common medical problem and is mostly iatrogenic in patients with diabetes mellitus. In contrast, spontaneous hypoglycemia is relatively uncommon and poses a significant diagnostic challenge. A definitive diagnosis can be made for spontaneous hypoglycemia by using a systematic approach. After confirming the presence of a hypoglycemic disorder, a detailed history should be taken which often suggests a specific underlying cause and can guide further testing. A complete hypoglycemic blood panel must be analyzed (Plasma glucose, insulin, C-peptide, proinsulin, Beta-hydroxybutyrate, sulphonylurea screen, insulin autoantibody) during a spontaneous event or after provoked by a fasting test/mixed meal challenge test, and patients must be categorized based on their clinical status (seemingly well and unwell).
J Assoc Clin Endocrinol Diabetol Bangladesh, July 2024;3(2): 58-64
Pencegahan Bullying di Lingkungan Sekolah melalui Pembentukan Polisi Kecil sebagai Upaya Optimalisasi Kesehatan Mental Anak
Authors: Khasanah Nopi Nur , Jannah Ghina Muhibbatul , Abdillah Ajid , Silviani Vicky Nurul , Listianah Liya Maya , Setyawan Muhamad Andri
Published: December 2024

The social environment of MI Al-Mahmud Kumpulrejo in recent years has been identified as having cases of verbal bullying. The school has tried to prevent verbal bullying by giving sanctions and education in every lesson, but there are still cases of bullying. The solution offered is the Formation of Petty Police to reduce verbal bullying through peer group and peer counselor methods. One of the tasks of the Petty Police is to help create a safe and comfortable school environment by maintaining order and security in the school, as well as reporting to teachers or providing counseling if cases of bullying are found so that prevention and handling can take place more quickly. The formation of the Petty Police was attended by 12 students who were selected based on criteria that had been determined together with the teacher. The PKM activities showed decreased cases of verbal bullying in the school environment through the active role of the Petty police, who carried out their duties well. In conclusion, the formation of the petty police was considered quite effective in efforts to optimize children's mental health in schoolsABSTRAKLingkungan sosial MI Al-Mahmud Kumpulrejo dalam beberapa tahun terakhir teridentifikasi memiliki kasus bullying verbal. Pihak sekolah telah melakukan upaya pencegahan bullying verbal melalui pemberian sanksi dan edukasi di setiap pembelajaran, namun masih terdapat kasus bullying verbal di sekolah. Solusi yang ditawarkan ialah Pembentukan Polisi Kecil untuk menurunkan kasus bullying verbal melalui metode peer group dan peer counselor. Salah satu tugas Polisi Kecil adalah membantu menciptakan lingkungan sekolah yang aman dan nyaman dengan menjaga ketertiban dan keamanan di sekolah, serta melaporkan ke guru atau melakukan konseling  jika ditemukan kasus bullying agar pencegahan dan penanganannya dapat berlangsung lebih cepat. Pembentukan Polisi Kecil diikuti oleh 12 siswa yang dipilih berdasarkan kriteria yang telah ditentukan bersama guru. Hasil kegiatan PKM menunjukan adanya penurunan kasus bullying verbal di lingkungan sekolah melalui peran aktif dari polisi kecil yang telah menjalankan tugasnya dengan baik. Kesimpulan, pembentukan polisi kecil dinilai cukup efektif dalam upaya optimalisasi kesehatan mental anak di sekolah.
Analisis Kesenjangan Kualitas Pelayanan PPS Belawan Dalam Implementasi Penerimaan Negara Bukan Pajak (PNBP) Pascaproduksi
Authors: Manoppo Anneke Karinda Sherly , Ruchimat Toni , Natsir Moh.
Published: December 2024

Penerimaan Negara Bukan Pajak (PNBP) merupakan salah satu sumber penerimaan negara yang saat ini keberadaannya menjadi semakin penting. PNBP pasca produksi merupakan hasil reformasi kebijakan yang dihasilkan oleh KKP dalam rangka peningkatan pengelolaan perikanan nasional secara lebih efisien dan berkelanjutan. Penelitian ini bertujuan untuk mengevaluasi kualitas layanan  terhadap pelaksanaan kebijakan PNBP pasca produksi. Penelitian dilakukan melalui observasi dan wawancara dengan responden yaitu pelaku usaha. Metode penentuan responden dilakukan secara purposive sampling dengan jumlah responden sebanyak 60 orang. Analisis data menggunakan analisis gap lima aspek dimensi pelayanan. Pengolahan data analisis gap menggunakan perangkat lunak Microsoft excel. Hasil penelitian berupa informasi kesenjangan kualitas pelayanan melalui persepsi pelaku usaha terhadap penerapan PNBP pasca produksi di PPS Belawan. Hasil analisis gap menunjukkan bahwa terdapat gap yang cukup tinggi pada lima aspek dimensi pelayanan yang dianalisis. Dimensi yang perlu menjadi prioritas utama untuk perbaikan dalam hal kesiapan PPS Belawan dalam implementasi PNBP pasca produksi adalah dimensi tangible dengan nilai gap sebesar -0.80 yang berkaitan erat dengan kesiapan infrastruktur untuk mendukung penerapan PNBP pasca produksi. Urutan prioritas berikutnya adalah dimensi reliable, empathy, assurances, dan responsiveness.
MODEL NAS (NUTRIENTS-ALGAL-SOCIETY): DINAMIKA HARMFUL ALGAL BLOOMS AKIBAT AKTIVITAS ANTROPOGENIK
Authors: Zakia Zulfa Siti , Wijayanto Mirda Prisma
Published: December 2024

HABs (Harmful Algal Blooms) atau ganggang mekar merupakan fenomena terjadinya peningkatan populasi alga di luar kendali (blooming) akibat peningkatan konsentrasi nutrisi di wilayah perairan. Peningkatan nutrisi dapat disebabkan oleh aktivitas antropogenik seperti pencemaran limbah. Dalam penelitian ini, telah dianalisis dinamika HABs akibat aktivitas antropogenik dengan metode pemodelan matematika. Model matematika yang diusulkan selanjutnya disebut sebagai model NAS (Nutrients-Algal-Society). Model NAS terdiri dari tiga variabel yaitu N (Nutrients), A (Algal), dan S (Society). Novelti dari penelitian ini meliputi penentuan titik kesetimbangan, analisis kestabilan titik kesetimbangan, serta skenario optimal pengendalian HABs. Berdasarkan analisis kestabilan, didapatkan bahwa titik kesetimbangan bebas HABs bersifat stabil artinya sistem tidak akan mengalami blooming alga apabila laju pertumbuhan alga lebih kecil dari tingkat kesadaran masyarakat dalam pengendalian HABs. Pengendalian HABs dapat dilakukan dengan menurunkan aktivitas antropogenik seperti mengurangi nutrisi dengan membatasi pencemaran limbah, serta melakukan pengendalian alga sesegera mungkin pada saat fase awal blooming. Skenario terbaik pengendalian HABs dicapai ketika laju pertambahan nutrisi bernilai minimum dan tingkat kesadaran masyarakat bernilai maksimum.
Studi Modifikasi Permukaan Serat Rami untuk Meningkatkan Karakteristik Mekanik Biokomposit PLA Berpenguat Serat Rami
Authors: Hidayah Elok , L. Jamilah Umi , Rosyidah Aminatur , Idiawati Riris
Published: December 2024

Studi berbasis review ini bertujuan untuk mengeksplorasi efektivitas modifikasi permukaan serat rami dalam meningkatkan kinerja biokomposit berbasis PLA. Metode penelitian melibatkan analisis komprehensif terhadap artikel-artikel dari jurnal bertaraf internasional, yang dikumpulkan dari tahun 2015 hingga 2024. Studi analisis dilakukan terhadap artikel yang berfokus pada modifikasi permukaan serat rami, dan aplikasi serat rami hasil modifikasi sebagai penguat biokomposit PLA. Hasil studi terhadap beberapa artikel menunjukkan bahwa alkalisasi menggunakan NaOH diidentifikasi sebagai metode yang paling efektif, karena mampu meningkatkan kekasaran permukaan serat, memperkuat interaksi serat-matriks, dan meningkatkan kristalinitas. Perlakuan lain, seperti aplikasi silane, thermal annealing, dan coupling agent, juga memberikan kontribusi pada ikatan yang lebih baik serta peningkatan sifat mekanik. Hasil penelitian menunjukkan bahwa kombinasi berbagai perlakuan permukaan dapat mengoptimalkan sifat biokomposit rami/PLA, menjadikannya pilihan yang cukup baik untuk aplikasi material berkelanjutan.
SOUNDSCAPES OF DEFIANCE: RESISTANCE IN UKRAINIAN POP MUSIC AFTER THE ONSET OF RUSSIA’S FULL-SCALE INVASION
Authors:   University of Alberta (Edmonton), Zaitseva-Herz Olga
Published: December 2024

Since the beginning of the full-scale Russian invasion in February 2022, the
Ukrainian pop music scene has undergone a profound and rapid transformation, with

artists redefining their music as powerful cultural and political statements. Once main-
ly heavily influenced by global pop trends, Ukrainian musicians now incorporate folk-
loric and ethnic motifs, using them as key symbols of resilience, heritage, and political

resistance. This shift builds upon earlier waves of cultural resurgence that followed

Ukraine’s independence and the 2014 Revolution of Dignity [Sonevytsky 2019]. How-
ever, the 2022 invasion has accelerated the integration of these elements even more,

turning them into prominent markers of national identity and unity within both do-
mestic and international contexts.

This article investigates how contemporary Ukrainian musicians incorporate the
Ukrainian language, folk elements, and visual symbols to express national identity
and resilience during wartime. I hypothesize that elements associated with heritage

and the traditional Ukrainian culture – such as folk singing styles, traditional instru-
ments, and ethnic visual markers – are increasingly used in pop music as forms of

cultural resistance since the beginning of the full scale invasion in February 2022.

This integration serves not only as an assertion of identity but also as a means of pre-
serving and strengthening Ukraine’s cultural legacy in the face of existential threats.
Mykhailo Tymofiiv – an Ethnoorganolgist (on the Anniversary of the Artist, Researcher, and Educator)
Authors:   Lviv National Music Academy named after Mykola Lysenko, Pavliv Yarema
Published: December 2024

This article highlights the key milestones in the creative biography of the promi-
nent multi-instrumentalist, Honored Master of Ukraine, educator, composer, researcher,

and collector of folk musical instruments, Mykhailo Tymofiiv (b. 1944). The analysis

of the artist’s professional activities is framed through the examination of his scho-
larly contributions, research, performing, reconstructive, and pedagogical achieve-
ments, ultimately defining his role in Ukrainian ethnoorganology. Special attention is

given to the familial atmosphere and traditional environment in which the musician
grew and developed. Mykhailo Tymofiiv refined and expanded the experience of a
traditional pipe player and master instrument maker. His innovations regarding the

tonal capabilities of the Hutsul traditional pipe „frilka”, particularly its chromaticiza-
tion, were inspired by Tymofiiv’s deliberate effort to play this instrument in the aca-
demic concert and educational context.

Drawing on the repertoire foundation of arranged folklore, Mykhailo Tymofiiv
nurtured a cohort of distinguished pipe players who have achieved prominence as
concert performers. As a researcher, he conducts studies of musical instruments from

the Hutsul and Pokuttia regions, focusing on their structural, tonal, acoustic, and tech-
nical and performance parameters, as well as their genesis, development, and contem-
porary functionality. The specifics and varieties of fingering techniques for playing

Hutsul aerophones in relation to the music performed on them remain a constant

theme in Tymofiiv’s conference presentations, lectures, and master classes. The schol-
ar has made a significant contribution to the study of traditional Hutsul violin music.

In 1975, he recorded, on his personal reel-to-reel tape recorder, solo and duet perfor-
mances by the traditional violinist Ivan Meniv (“Meniuk”) from Kosmach (1910–

1984). М. Tymofiiv has also gathered extensive materials on the traditional musicians
of the village of Myshyn.
Today, the ethnoorganologist places particular emphasis on the following aspects
of musical instrument research: 1) exploring the tonal and tuning possibilities of the
most archaic aerophones preserved in the various folk traditions; 2) reconstructing

bone flutes from the Late Paleolithic era, discovered during archaeological excava-
tions in Molodovo, Chernivtsi region; 3) improving the system of fingering notation

for pipe (sopilka/frilka) music.
Analytical materials on the use of immersive technologies in secondary education institutions
Authors: Burov O. Yu. , Lytvynova Svitlana , Nosenko Yu. G. , Sukhih Alisa
Published: December 2024

The analytical materials analyze the state of use of immersive technologies in international space (scientific interest of foreign researchers in the problem, dynamics of the market of immersive technologies in education in the global context). An analysis of the state of use of immersive technologies in general secondary education of Ukraine is proposed (current immersive developments, educational activities of UNICEF and Ukrainian educational hubs, cultural and educational activities with immersive technologies), the results of a survey of Ukrainian teachers on the use of immersive technologies in educational activities are presented. Challenges, trends and prospects for the implementation of immersive technologies in general secondary education institutions are identified. The presented materials can be used by scientists, postgraduate students, doctoral students, lecturers, researchers, teachers of general secondary education institutions.
Digital transformation of open scientific and educational environments: monograph
Authors: Bondarenko O. V. , Burov O. Yu. , Vakaliuk T. A. , Ivanova Svitlana , Karnishina D. A. , Kondratova L. G. , Lytvynova Svitlana , Luparenko Liliia , Mariienko Maiia , Mintii I. S. , Nechypurenko P. P. , Novytska T. L. , Ovcharuk Oksana , Oleksiuk V. P. , Pinchuk Olga , Prydacha T. V. , Selivanova T. V. , Semerikov Serhii , Soroko Nataliia , Spirin Oleg , Starova T. V. , Fadieeva N. P. , Shyshkina Mariia , Yatsyshyn Anna
Published: December 2024

The monograph was prepared for the 25th anniversary of the founding of the Institute for Digitalisation of Education (until 2022 – the Institute of Information Technologies and Learning Tools) of the National Academy of Educational Sciences of Ukraine. The results of selected scientific research by scientists at the institute on the problems of digitization of education and the field of pedagogical sciences are presented. International approaches to the digitalization of education and trends in its digital transformation and digital development are outlined. The publication is addressed to scientific and scientific-pedagogical workers, teachers, heads of educational institutions, graduate students, doctoral students, and a wide range of people interested in the digital transformation processes of education and pedagogical science of Ukraine.
Impacts of Emotional Intelligence on Job Satisfaction and Job Performance of Employees: Evidence From Bangladesh
Authors: Karim Zahidul , Hossain Saha Iqbal , Shahid Sumaya Fatema Binte
Published: December 2024

Drawing on trait emotional intelligence theory, this study explores the interplay of emotional intelligence (EI), job satisfaction (JS), and job performance (JP) in Bangladesh. Analyzing data from 402 employees and managers across various organizations, SEM analysis via WarpPLS and regression in SPSS reveal significant findings: EI positively influences both JS and JP. Moreover, JS partially mediates the EI-JP relationship. The study underscores the nuanced relationships among EI, JS, and JP, offering insights for scholars and managers into optimizing workplace dynamics. These findings contribute to understanding and leveraging emotional intelligence in enhancing job satisfaction and performance across diverse organizational settings.
Seismic response of monopile-supported wind turbine systems: combination laws for kinematic and inertial interaction
Authors: Ng Chun Hei
Published: December 2024

The dynamic soil structure interaction imposes both kinematic and inertial interactions on monopile-supported wind turbines. The two effects can be calculated individually, but there is no clear guidance in the current design standard for combining them. A theoretical study using the finite element method to model a simplified single degree of freedom system
has been conducted to analyse the phase relationship between the two effects and obtain the combination laws through parametric studies using the enhanced hysteresis control soil constitutive model. The results show that when the fundamental frequency of the soil is smaller than the superstructure, an in-phase relationship is observed. Monopile’s bending moments from the two loadings have different signums. Considering the inertial loading alone with an additional 5% modification is sufficient to capture the maximum bending moment and the profile. When the natural frequency of the soil is larger than the superstructure, an out-of-phase relationship is observed. The kinematic loading has a significant domination on the lower part of the pile. The worst-case scenario can be obtained when both loadings are combined using the simple addition rule. These findings enable engineers to combine two loadings in a simple manner, avoiding performing the lengthy dynamic time-history numerical analysis and facilitating an efficient design.
ECZANE VE AKTARLARDA SATILAN BAZI SUSAM YAĞI ÖRNEKLERİ ÜZERİNDE KALİTE KONTROL ÇALIŞMALARI
Authors: Şahin Halilibrahim Aykut , Kaya Gülen İrem
Published: December 2024

Amaç: Sabit yağlar; doğal kaynaklardan elde edilen ve vücutta dahilen ve haricen çeşitli fizyolojik etkilere sebep olan karışımlardır. Sabit yağlar elde edildiği bitkiye bağlı olarak serbest yağ asitleri, bunların gliserol esterlerini, aromatik bileşikler, fenolik bileşikler, fitosteroller ve vitaminler gibi bileşenleri içerirler. Piyasada satılan sabit yağların kaynağına ve kalitesine dair doğru bilgiye ulaşmak her zaman mümkün olmamaktadır. Fitoterapide terapötik ajan olarak ve aromaterapide taşıyıcı yağ olarak, farmakope kalitesinde olan sabit yağlar tercih edilmelidir. Sabit yağlardan biri olan susam yağı fitoterapide dahilen kabızlık, özellikle de diskezi tedavisinde kullanılırken, haricen romatizmal ağrılarda masaj yağı olarak ve cilt kuruluğuna bağlı rahatsızlıklarda yumuşatıcı olarak kullanılmaktadır. Bu çalışmamızda etkileri ve fitoterapide kullanımlarından yola çıkılarak, eczane ve aktarlarda satılan bazı susam yağı örneklerinin Türk Farmakopesi 2017’ye uygunluğunun değerlendirilmesi hedeflenmiştir.
Gereç ve Yöntem: Bu çalışmada eczane ve aktarlarda satılan 6 farklı ticari susam yağ örneği üzerinde Türk Farmakopesi 2017’de susam yağı için belirtilen; genel özelliklerden, asit değeri, peroksit sayısı, % sabunlaşmayan madde miktarı, bağıl yoğunluk ve kırılım imleci tayinleri yapılmıştır. Çalışmamızda ayrıca yağın içindeki alkali safsızlıklar ve yabancı yağ olarak pamuk tohumu yağı arama testleri yürütülmüştür. Bunun yanında susam yağı örnekleri ile farklı yağ örnekleri ince tabaka kromatografisi (İTK) yöntemiyle karşılaştırılmıştır.
Sonuç ve Tartışma: Piyasadan temin edilen numunelerle yapılan farmakope analizleri sonucunda elde edilen veriler ışığında; analizi yapılan susam yağı örneklerinden 2 tanesinin farmakopede belirtilen bütün kalite değerlerine uyduğu görülmektedir. Hiçbir yağ örneğinde alkali safsızlık ve pamuk tohumu yağı tespit edilmemiştir. İTK ile yapılan çalışmada bir susam yağı örneğinin farklı bir yağ ile karıştırılmış olabileceği sonucuna varılmıştır. Örnek olarak temin edilip çalışılan susam yağlarının yapılan farmakope analizleri sonuçları, piyasadaki pek çok susam yağının farmakope kalitesinde olmadığını ortaya konmuştur.
POLİDOPAMİN TEMELLİ NANOSİSTEMLERİN İLAÇ TAŞIYICI SİSTEM OLARAK VE TEDAVİ POTANSİYELLERİ
Authors: Turan Ayhan Eda , İlbasmış Tamer Sibel
Published: December 2024

Amaç: Polidopamin (PDA), dopamin monomerinin oto-oksidasyon ve polimerizasyon sürecinin son ürünüdür. PDA, özellikle fototermal dönüşüm yeteneği, ilaç bağlama kapasitesi, çok yönlü adezyon ve biyoadezyon yeteneği, pH değişimine duyarlı olma özelliği ve yüksek biyouyumluluk ile biyomedikal alanlarda büyük potansiyel göstermiştir. Ayrıca taşıdığı üstün özellikler, PDA temelli nanopartikülleri ilaç taşıyıcı sistemler ve tedaviler için potansiyel hale getirmiştir. Bu derlemede, PDA'nın, polimerizasyon mekanizmalarının ve PDA temelli nano-sistemlerin çeşitli hastalıkların tanı ve tedavisindeki potansiyellerinin kapsamlı bir şekilde değerlendirilmesi, özellikle PDA'nın tıp ve eczacılık alanındaki rolünün belirgin hale getirilmesi amaçlanmaktadır.
Sonuç ve Tartışma: Yapılan literatür araştırmalarında; üstün özellikleriyle PDA temelli nanosistemlerin, birçok alanda tanı ve tedavi için umut vadedici sistemler olduğu görülmüştür. PDA nanopartiküllerin partikül büyüklüğü, stabilitesi, ilaç salım optimizasyonu, biyodağılım ve uzun vadeli toksisite analizi gibi konularda çalışmalar her geçen gün artmaktadır. PDA'nın metabolizma ve biyodegradasyon mekanizmalarının anlaşılması gibi tam olarak netleştirilememiş bilgilerin aydınlatılmasıyla bu sistemlerin tanı ve tedavide etkin olarak yer alabileceği düşünülmektedir.
SJÖGREN SENDROMUNDA GÜNCEL İLAÇ TEDAVİSİ
Authors: Öztürk Aybüke , Uzunhisarcıklı Ebru
Published: December 2024

Amaç: Bu derleme çalışmasında Sjögren (Sikka) sendromuna ilişkin bugüne kadar elde edilen bulgulara ve tedavi yöntemlerine odaklanılması amaçlanmıştır. Bu bağlamda Sjögren sendromunun epidemiyolojisi, klinik bulguları, tanı yöntemleri ve tedavisine yönelik, çoğunlukla gözlemsel, açık etiketli ve randomize klinik çalışmalardan elde edilen mevcut kanıtlar ile Pilokarpin ve Sevimeline gibi muskarinik agonistler, antimalaryaller (Hidroksiklorokin); Metotreksat, Leflunomid, Azatioprin, Sülfasalazin, Mikofenolik asit ve Siklosporin gibi geleneksel biyolojik olmayan hastalığı modifiye eden antiromatizmal ilaçlar (DMARD'ler); ve aralarında alkilleyici ajan Siklofosfamid ve B hücrelerini hedef alan anti-CD20 antikoru Rituksimab'ın da bulunduğu diğer güçlü ajanlardan bahsedilmiştir.
Sonuç ve Tartışma: Hastalar, tanıyı doğrulamak ve hastalığın derecesini belirlemek için kapsamlı bir tedavi öncesi değerlendirmeye tabi tutulmalı ve buna göre terapötik yaşam tarzı değişiklikleri ile farmakolojik ajanlardan yararlanmalıdır. Orta ve şiddetli tutulumu olan hastalar genellikle klinik tabloya, dokulara ve etkilenen organ sistemine bağlı olarak immünsüpresiflerin ve biyolojik ajanların kullanımı da dahil olmak üzere sistemik tıbbi tedaviye ihtiyaç duymaktadırlar.
ЛІНІЯ АРПАДА – ОБОРОННА СПОРУДА У СХІДНИХ КАРПАТАХ ЧАСІВ ДРУГОЇ СВІТОВОЇ ВІЙНИ
Authors: Куцька Олеся Миколаївна
Published: December 2024

Дослідження розкриває підготовку гітлерівських військ до оборони по лінії Арпада та Червоної Армії до Східно-Карпатської операції; описує процес будівництва угорськими військами фортифікаційних споруд у Карпатах та особливості їх розміщення на території; визначає результативність бойових дій сторін у гірсько-лісовій місцевості наприкінці серпня – жовтні 1944 року та роль лінії Арпада в їх реалізації. З’ясовано: Червона Армія не прорвала оборону в Карпатах, а подолала гори, рухаючись за відступаючою 1-ю угорською армією. Обхід радянськими військами лінії Арпада не можна вважати її невдачею у горах. Це стратегічний маневр, який відбувся внаслідок невдалих штурмів укріплень противника 4-м Українським фронтом поряд із результативним наступом 1-го та 2-го Українських фронтів на інших напрямках
Practices and Challenges of Environmental Sustainability in Tourism: Insights from Malino, Indonesia
Authors: Jasman
Published: December 2024

This study aims to evaluate the implementation of environmental aspects in sustainable tourism development in Malino, Tinggimonjong District, Gowa Regency, using a quantitative descriptive method. Data collection was conducted through surveys to gather information on the application of environmental criteria in the area. Data analysis was performed using spatial overlay techniques to assess the extent of criterion implementation and identify areas needing improvement. The findings indicate that Malino has implemented 20 out of 27 relevant environmental criteria. These include waste management, greenhouse gas emission control, and eco-friendly transportation. However, some areas still require improvement, particularly regarding infrastructure and supporting services. The study also highlights the challenge of balancing tourism development with environmental conservation. Effective environmental management is crucial for ensuring tourism sustainability. The main conclusion is the need for better spatial planning and improved management practices to protect natural areas from negative impacts and ensure the long-term sustainability of tourism development in Malino.
A Quantitative Study on Culinary Tourism: The Effect of Service Quality on Purchase Decision Through Trust and Word of Mouth
Authors: Andika Isma  , Alisyahbana Andi Naila Quin Azisah , Rahmawati Rahmawati
Published: December 2024

This study aims to investigate the effect of service quality on purchasing decisions on culinary tourism, by considering the role of Trust and Word of Mouth as mediating variables. This study uses a quantitative approach of descriptive research and explanatory research that describes the relationship between variables with a population of all visitors to Makassar City's typical restaurants or stalls which are the main destinations for culinary tourism. Data analysis in this study PLS-SEM Warp Analysis and Sobel Test. The results showed that: 1) Directly Service Quality, Trust, Word of Mouth have a significant effect on Purchase Decision. 2) Indirectly Service Quality, Trust, Word of Mouth have a significant effect on Entreprenurial Intention. Based on the results of this study, it is known that consumers feel that joining a community or group can fulfill the information needs needed related to culinary tourism, then with the spread of word of mouth and good trust, it will increase the reputation of a place of Makassar City Restaurant or Warung which is the target of culinary tourists so that it needs to be given more attention in terms of service quality.
Code-Switching in Podcast: A Case Study of Boy William and Cinta Laura
Authors: Sadimah Fitri , Afriliani
Published: December 2024

In Indonesian society, code switching has become a popular communication method among celebrities. In addition to being a simple means of expressing specific ideas, some speakers find that code-switching facilitates more natural communication. This study aims to examine the various code-switching techniques used by Boy William in his podcast with Cinta Laura. They employ code switching in their conversation, which will be the primary focus of this study. Specifically, it will investigate the variety of code-switching techniques used in Boy William and Cinta Laura's exchange and how each user employs them when conversing. A quantitative descriptive method is employed in this study. This study's findings demonstrate four different forms of code switching. Nine code switching data were discovered during the study, including two inter-sentential, two intra-sentential, three emblematic, and two establishing continuities with the previous speaker data. The code switching is happened to highlight the utterance, explaining the information, and giving examples.
Multi-User Digital Platform for Data Mining, Decisions’ Roots Design and Decisions’ Root-Based Neural Networks Training - D2D.Platform
Authors: Alekseev Aleksandr
Published: December 2024

The multi-user digital platform is described, primarily performed for data mining and decision-making support. The discussed platform was named as "Data to Decisions" or shortly D2D.Platform. In spite of the same name discussed platform is differed from the "Data to Decisions Portal and Dashboard" of the U.S. General Services Administration. The main purpose of the suggested digital platform is development of decisions’ roots – graphical tool for decision making support, and training of decisions' root-based neural networks – new type of incompletely connected neural networks. Besides data mining function of the D2D.Platform, the last one is also a no-code integrated development environment and a database management system.
Disentangling emotional source memory: a mega-analysis on the effects of emotion on item-context binding in episodic long-term memory
Authors: Ventura-Bort Carlos , Katsumi Yuta , Wirkner Janine , Wendt Julia , Schwabe Lars , Hamm Alfons O. , Dolcos Florin , Weymar Mathias
Published: December 2024

Introduction

It has long been known that highly arousing emotional single items are better recollected than low arousing neutral items. Despite the robustness of this memory advantage, emotional arousing events may not always promote the retrieval of source details (i.e., source memory) or associated neutral information.

Methods

To shed more light on these effects, we pooled data from seven different studies (N = 333) to investigate the role of emotion on item-context binding in episodic memory, as well as potential interacting factors (e.g., encoding instructions, type of retrieval task, or acute stress). In all studies, participants incidentally encoded common neutral objects (i.e., items), overlaid on different pleasant, neutral, or unpleasant background scenes (i.e., contexts). One week later, the encoded objects were presented intermixed with new ones and memory for item and source contextual details was tested, also considering the contribution of recollection and familiarity-based processes.

Results

Linear mixed models revealed a recollection-based retrieval advantage for unpleasant and pleasant source contextual details compared to neutral ones. Bayes hypothesis-testing analysis further indicated decisive evidence in favor of a relevant role of emotional arousal and recollection in source contextual memory. Regarding item memory, linear mixed models revealed enhanced recollection-based memory for items encoded in pleasant contexts compared to their neutral and unpleasant counterparts. However, Bayes analysis revealed strong to moderate evidence for models without affective category (or its interactions), indicating that the affective category of contexts in which objects were paired during encoding had little influence on item memory performance.

Discussion

The present results are discussed in relation to existing evidence and current neurobiological models of emotional episodic memory by also emphasizing the role of predictive processing as a useful conceptual framework to understand the effects of emotion on memory for source details and associated neutral information.
An Analytical Network Process (ANP) Approach to the Public Policy Innovation Strategy Model
Authors: Putra Cahyono Jordan
Published: December 2024

This study explores the innovation model and the role of public policy in tourism development within Pamekasan Regency, utilizing the Analytical Network Process (ANP) approach. It primarily seeks to identify and rank key factors that affect the effectiveness of tourism policy and offer strategic recommendations for improving its development. The research adopts a mixed-method approach that encompasses qualitative insights, including expert interviews and extensive literature reviews, as well as quantitative data collected through a structured questionnaire based on ANP administered to experts, managers, and public decision makers in the tourism sector. Results indicate that, among others, human capital is the most important component of tourism development, followed by institutional/bureaucratic improvements, then accessibility. This emphasis on human capital is in line with endogenous growth theory, which underlines the role played by people in driving economic prosperity. On the other hand, institutional improvement promotes efficient policies for promoting tourism, while accessibility, although ranked lower, still remains crucial for enhancing visitors’ experiences. The recommendations for strategy consist of rigorous training for personnel in the tourism sector, the easing of license and permit procedures, and the development and enhancement of transportation and communication networks. The aim of these strategies is to promote a balanced and sustainable growth within the tourism industry. The study’s rigorous empiricism and theoretical framework offer strong support for the suggested strategies and make theoretical and application-level contributions to tourism management. In this research, by connecting the research results to the endogenous growth theory and supporting the results with a literature review, useful information and strategic solutions for international policymakers and stakeholders in Pamekasan Regency are provided.
Analyzing Instagram Engagement to Forecast Domestic Tourist Trips in Lake Toba and North Sumatra
Authors: Nurmawati Erna , Sugiyarto Teguh , Artiari Navika , Rahmawati Adelina
Published: December 2024

The tourism industry is well known as one booster for economic development. The advance of the tourism industry will lead to the improvement of other economic sectors. Therefore, the Indonesian government is taking steps to ensure the development of its tourism industry by launching 10 super-priority destinations (DSP). Despite numerous efforts and interventions, evidence suggests that the demand for the tourism industry in certain DSPs remains unsatisfied. This also holds true for Lake Toba in North Sumatra. Therefore, it is important to understand how to promote the destination site effectively and increase the number of domestic visitors. This study is aimed at assessing the impact of digital marketing through Instagram to determine the number of domestic tourist trips. The engagement rate (ER) on Instagram posts represents the impact of digital marketing. The result reveals that the topic 'cultural tourism and its activities that develop the economy' has the highest average ER, reaching 692.48. Further analysis reveals that the LSTM model, with independent variables TPK, GTI, and ER on the topic of 'ticket information and vacation packages', is the most effective model for predicting the number of domestic tourist trips to North Sumatra. This analysis emphasizes the crucial role of digital marketing to shape the demand for the tourism industry. The conclusion is based on the significant influence of the Google Trends Index (GTI) and ER on Instagram posts, which serve as a gauge for domestic visitor numbers. The related stakeholders must consider this aspect to sustain its business.
Contribuições dos estudos de discurso na análise da comunicação em plataformas digitais
Authors: Dos Reis Ruth de Cássia , Zanetti Daniela
Published: December 2024

O propósito deste artigo é discutir a contribuição dos estudos de discurso no contexto da comunicação contemporânea, a construção de corpora e estratégias de análise dos processos discursivos em ambiente on-line. Marcado pelas mídias sociais, o ecossistema comunicacional da atualidade coloca em cena uma miríade de atores que se movimentam numa trama de múltiplas conexões e têm nas suas textualidades uma das formas de produção do social. Inicialmente, são apresentadas as principais contribuições teóricas dos estudos de discurso que são apropriadas pelo campo da Comunicação, incluindo autores como Foucault, Pêcheux, Fairclough, Dijk, Laclau, Mouffe, Paveau entre outros. Numa segunda parte, são discutidos alguns dilemas metodológicos e procedimentos possíveis de coleta e análise dos dados. Tendo a revisão bibliográfica como caminho metodológico, bem como a experiência no desenvolvimento de trabalhos de análise do discurso em ambientes digitais, apresentamos reflexões sobre os desafios de pesquisa e destacamos a importância da conexão entre o trabalho humano desempenhado pelo pesquisador e o trabalho maquínico desenvolvido por softwares na obtenção de resultados profícuos para análise do discurso em mídias sociais digitais.
Elementos para uma produção audiovisual intercultural: estudo de caso sobre a série Índio Presente
Authors: Panis Kaseker Mônica , Nakamura Gallassi Adriana
Published: December 2024

Apresentamos reflexões sobre como os processos de autorrepresentação midiática indígena provocam transformações na forma como os comunicadores não indígenas se relacionam com a temática, em especial os que atuam na produção audiovisual, a partir de um estudo de caso da série Índio Presente. Essa série foi lançada em 2017 e veiculada em TVs universitárias ou educativas regionais e nacionais, além de disponibilizada na plataforma digital Futura Play, pertencente ao Canal Futura, até 2020. Trata-se de 13 episódios que abordam, a cada edição, um equívoco que permeia a visão do senso comum sobre os povos originários. Índio Presente foi produzida por não indígenas para o público não indígena e traz em seu conteúdo entrevistas com autoridades e “personagens agentes”, tanto indígenas como não indígenas. A metodologia envolve revisão bibliográfica sobre a representação imagética dos povos indígenas, mapeamento dos estereótipos construídos historicamente nessas representações e análise da narrativa e das fontes ouvidas na série Índio Presente. Conclui-se que o giro decolonial não representa somente a autorrepresentação, mas o deslocamento e descentramento causados na prática dos comunicadores não indígenas ao desenvolver uma produção intercultural sobre os povos indígenas.
Desinformação e economia política nas plataformas digitais
Authors: Jesus-Silva Thiago Henrique de
Published: December 2024

Este artigo investiga o papel das plataformas digitais, como Facebook, YouTube e WhatsApp, na disseminação de desinformação, fraudes publicitárias e teorias da conspiração, à luz da Economia Política da Desinformação (EPD). O objetivo principal é entender como o modelo de negócios dessas plataformas, focado no engajamento e lucro, amplifica a desinformação. Utilizando uma análise de conteúdo sobre relatórios de desinformação climática, fraudes digitais e golpes, a pesquisa mapeia padrões comuns nas plataformas digitais, identificando os principais atores e mecanismos envolvidos. O processo metodológico baseou-se na categorização de dados extraídos de documentos fornecidos pelo NetLab e no uso de tabelas para identificar as principais palavras-chave e padrões. Os resultados mostram que a monetização do engajamento nas plataformas digitais cria incentivos econômicos que favorecem a disseminação de desinformação, colocando em risco a integridade da informação e exacerbando a polarização política. Conclui-se que a desinformação é não apenas uma questão de erro ou mal-entendido, mas parte de uma estratégia estrutural que privilegia os interesses econômicos das grandes plataformas. A pesquisa sugere a necessidade de regulamentação dessas plataformas e de políticas públicas voltadas para a contenção da desinformação.