bluuebunny/crossref_metadata_2025 huggingface dataset:
Pendekatan TaRL terintegrasi Social Emotional Learning (SEL) dengan model PBL untuk meningkatkan minat dan hasil belajar siswa
Authors: Fajri Nur Lailatul , Nurita Tutut , Muslimah Mar’atul
Published: January 2025

Penelitian dilatar belakangi oleh minat serta hasil belajar siswa yang rendah pada pembelajaran IPA. Proses pembelajaran IPA belum sepenuhnya dapat memenuhi kebutuhan dan minat siswa sehingga menyebabkan hasil belajar siswa rendah. Pengajaran menggunakan pendekatan Teaching at The Right Level (TaRL) terintegrasi Social Emotional Learning (SEL) dengan model PBL dapat memfasilitasi berbagai karakteristik dan minat belajar siswa. Penelitian yang dilakukan bertujuan untuk mengetahui peningkatan minat belajar dan hasil belajar pada pelajaran IPA materi Unsur, Senyawa dan Campuran. Jenis penelitian menggunakan Penelitian Tindakan Kelas (PTK) yang dilakukan sebanyak dua siklus dengan tiap siklus mengandung empat tahapan yakni perencanaan, pelaksanaan, pengamatan, kemudian diakhiri dengan refleksi. Data minat belajar diperoleh melalui angket minat belajar sedangkan data hasil belajar diperoleh dari tes tertulis yang kemudian dianalisis secara kuantitatif dan kualitatif. Hasil penelitian menunjukkan rerata persentase minat belajar siswa sebelum tindakan adalah 73,85% (cukup) kemudian meningkat menjadi 79,97% (sangat tinggi) setelah pemberian tindakan. Pada hasil belajar diperoleh peningkatan dengan rerata nilai sebesar 71,87 dengan ketuntasan belajar sebesar 77,42% pada siklus I dan menjadi 82,19 pada siklus II dengan ketuntasan belajar 90,32%. Oleh karena itu, pendekatan TaRL terintegrasi SEL dengan model PBL dapat meningkatkan minat dan hasil belajar siswa.
Heterosis dan Heterobeltiosis Pertumbuhan dan Hasil 29 Genotipe Melon (Cucumis melo L.)
Authors: Puspitasari Wiwit , Susilo Edi , Togatorop Eny Rolenti
Published: January 2025

Nilai heterosis dan heterobeltiosis merupakan parameter genetik yang bisa digunakan untuk menentukan calon hibrida unggul. Nilai heterosis dapat diduga melalui perbandingan nilai rata-rata F1 dengan nilai rata-rata kedua tetua dan perbandingan nilai rata-rata F1 dengan nilai rata-rata tertinggi salah satu tetua. Penelitian ini bertujuan untuk mengetahui nilai heterosis dan heterobeltiosis persilangan 29 genotipe melon. Bahan genetik yang digunakan dalam penelitian adalah 29 genotipe melon. Penelitian menggunakan Rancangan Acak Kelompok Lengkap (RAKL) faktor tunggal dan diulang sebanyak 3 kali. Karakter yang diamati adalah  diameter batang, panjang daun, umur panen, panjang buah, diameter buah, bobot buah, ketebalan daging buah, dan tingkat kemanisan buah. Persilangan yang menghasilkan nilai heterosis dan heterobeltiosis yang tinggi adalah G29xG4 untuk karakter panjang buah, diameter buah dan bobot buah, G9xG4 untuk karakter panjang buah, diameter buah dan ketebalan daging buah, G29xG9 dan G38xG4 untuk karakter panjang buah dan tingkat kemanisan buah, G4xG38 untuk karakter panjang buah dan ketebalan daging buah,  G29xG40 untuk karakter bobot buah dan ketebalan daging buah, serta G40xG4 dan G38xG40 untuk karakter bobot buah.
Efektivitas Model Pembelajaran Learning Cycle 5E terhadap Peningkatan Motivasi Belajar Peserta Didik Materi Koloid di SMA Muhammadiyah 7 Yogyakarta
Authors: Muryadi  , Sulistyaningsih  , Ainun Nisa Syarafina , Rahmawan Setia
Published: January 2025

Penggunaan model pembelajaran Learning Cycle 5E dapat meningkatkan motivasi belajar, hasil belajar, serta keterampilan kognitif dan sosial siswa secara keseluruhan. Penelitian ini bertujuan untuk mengetahui peningkatan motivasi belajar siswa kelas XI MIPA 1 SMA Muhammadiyah 7 Yogyakarta pada mata pelajaran kimia setelah menerapkan model pembelajaran Learning Cycle 5E pada materi koloid. Penelitian ini menggunakan metode penelitian tindakan kelas dengan dua siklus pembelajaran. Subjek penelitian adalah siswa kelas XI MIPA 1 SMA Muhammadiyah 7 Yogyakarta tahun pelajaran 2023/2024. Sumber data penelitian berasal dari guru dan siswa yang didapatkan melalui proses observasi, wawancara, dan angket. Pengambilan data dilakukan dengan menggunakan metode angket. Berdasarkan data yang diperoleh, diketahui bahwa penerapan model pembelajaran Learning Cycle 5E terbukti dapat meningkatkan motivasi belajar siswa di mana pada siklus I rata-rata motivasi peserta didik sebesar 72,23% meningkat menjadi 76,00% pada siklus II. Oleh karena itu, dapat disimpulkan bahwa model Learning Cycle 5E menjadi salah satu upaya yang dapat diterapkan oleh guru untuk meningkatkan motivasi belajar siswa, terutama pada mata pelajaran kimia sehingga dapat meningkatkan prestasi belajar peserta didik.
Pengaruh Model Pembelajaran Case Based Learning Berbantuan Ar terhadap Hasil Belajar dan Keterampilan Proses Sains Siswa di SMA Negeri 13 Samarinda
Authors: Parung Yasthin , Herliani Herliani , Maasawet Elsje Theodora , Rambitan Vandalita Maria Magdalena
Published: January 2025

Pendidikan saat ini mengedepankan peserta didik untuk aktif berpartisipasi dalam proses pembelajaran. Revolusi industri 4.0 memengaruhi pendidikan 4.0, yang melibatkan penggunaan teknologi digital, atau cyber system, dalam proses belajar. Dengan penggunaan teknologi tersebut memungkinkan proses pembelajaran berlangsung tidak terbatas ruang dan waktu, dengan arti proses pembelajaran tidak hanya diruang kelas dan pada saat jam belajar. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Case Base Learning berbantuan media Augmented Reality terhadap hasil belajar dan keterampilan proses sains pada materi sistem reproduksi siswa kelas XI SMA Negeri 13 Samarinda. Jenis penelitian yang digunakan oleh peneliti adalah quasy eksperimen dengan rancangan penelitian yaitu the one group pretest-posttest design. Adapun hasil analisis data yang diperoleh yaitu rata rata nilai pretest siswa adalah 50,13 dan posttest adalah 87,26 nilai N-gain yaitu sebesar 0,74 dengan kategori tinggi. Sehingga, dinyatakan terdapat pengaruh model pembelajaran case base learning terhadap hasil belajar dan keterampilan proses sains siswa kelas XI SMA Negeri 13 Samarinda.
model integrasi kearifan lokal (ikarme) dalam melatihkan keterampilan komunikasi ilmiah mahasiswa
Authors: Siagian Asister Fernando , Purba Jon Roi Tua , Saragih Richsya Octrasima
Published: January 2025

Penelitian ini bertujuan untuk mevalidasi model pembelajaran IKARME dalam melatihkan keterampilan komunikasi ilmiah mahasiswa. Penelitian ini menggunakan penelitian pengembangan melalui desain studi validasi dengan menguji dua kriteria yaitu validitas isi dan validitas konstruk. Validasi melibatkan tiga orang pakar melalui kegiatan Focus Group Discussion (FGD). Hasil penelitian menunjukkan bahwa model IKARME valid dan reliabel. Hal ini berdasarkan perhitungan yang menggunakan rumus Aiken, bahwa nilai V pada setiap butir instrumen 0,75 ≤ V ≤ 1 dengan kategori sangat valid dan koefisien reliabilitas untuk setiap aspek validitas berada rentang 100% sehingga hasil validitas yang dikembangkan reliabel. Disimpulkan bahwa model IKARME dinyatakan valid baik dari segi validitas isi dan validitas konstruk untuk dapat meningkatkan keterampilan komunikasi ilmiah mahasiswa.
Pengaruh model pembelajaran Terintegrasi Problem Based Learning dan Numbered Head Together Terhadap Hasil Belajar dan Berpikir Kritis Ssiswa Kelas X SMA Negeri 16 Samarinda
Authors: Indriani Yeni , Kurniawati Zenia Lutfi , Masitah  , Lumowa Sonja V.T
Published: January 2025

Penelitian tindakan kelas ini bertujuan untuk mengetahui hasil belajar dan berpikir kritis siswa kelas X SMA Negeri 16 Samarinda dengan Model Pembelajaran Terintegrasi Problem Based Learning (PBL) dan Numbered Head Together (NHT). Jenis penelitian yang digunakan oleh peneliti adalah quasi eksperimen dengan rancangan penelitian yaitu the one group pretest-posstest design. Adapun hasil analisis data dari uji hipotesis yaitu uji Independent Sample t-Test pada hasil berpikir kritis dengan taraf signitifikansi 5%. Hasil ini menunjukkan nilai sig. 2 tailed sebesar (0,001 < 0,05) atau thitung (3.687) > ttabel (2.01063) dan uji Analisis yang digunakan adalah uji Independent Sample t-Test pada hasil belajar dengan taraf signitifikansi 5%. Hasil ini menunjukkan nilai sig. 2 tailed sebesar (0,000 < 0,05) atau thitung (3.268) > ttabel (2.01063).Hal ini memperkuat bahwa terdapat pengaruh model pembelajaran terintegrasi problem based learning (PBL) dan numbered head together (NHT) terhadap hasil belajar dan berpikir kritis siswa kelas X SMA Negeri 16 Samarinda.Kata kunci : Problem Based Learning , Numbered Head Together, Hasil Belajar, Berpikir Kriti
Indonesia
Authors: Budiyatno  , Suseno Nyoto , Aththibby Arif Rahman
Published: January 2025

Penelitian ini bertujuan untuk mengembangkan Lembar Kerja Peserta Didik (LKPD) berbasis STEM dengan pendekatan Problem Based Learning (PBL) terhadap keterampilan proses sains dan kemampuan berpikir kritis siswa dalam pembelajaran IPA di SMP Abadi Perkasa. Model pengembangan yang digunakan adalah ADDIE, yang mencakup lima tahap: Analisis, Desain, Pengembangan, Implementasi, dan Evaluasi. Validasi produk dilakukan oleh ahli bahasa, materi, dan media, menunjukkan reliabilitas yang baik dengan nilai Cronbach’s Alpha ≥ 0,7. Implementasi LKPD dilakukan pada siswa kelas IX di SMP Abadi Perkasa, dengan uji coba menunjukkan peningkatan keterampilan siswa yang signifikan. Hasil analisis N-gain mencapai rata-rata 0,56, yang dikategorikan sebagai "sedang," yang menunjukkan adanya peningkatan keterampilan proses sains dan kemampuan berpikir kritis siswa. Data angket respon siswa menunjukkan efektivitas LKPD, dengan skor rata-rata 3,56 dan persentase efektivitas sebesar 89,1%, yang masuk dalam kategori “efektif.” Hasil penelitian ini menunjukkan bahwa penerapan LKPD berbasis STEM dengan pendekatan PBL memberikan dampak positif pada pembelajaran IPA, terutama dalam materi listrik dinamis, dengan memperkuat keterampilan proses sains dan kemampuan berpikir kritis siswa melalui pendekatan pembelajaran yang lebih kontekstual dan interaktif.
Kemampuan Literasi Sains Peserta Didik pada Materi Bentuk-bentuk Energi Melalui E-LKPD Berdiferensiasi dengan Bantuan Wizer.Me
Authors: Listyani Eustakia Frida , Sanita Yustina Yeyen , Dua Riong Maria Bernadetha , Wajong Alfonsus
Published: January 2025

Kemampuan literasi sains merupakan kompetensi yang harus dimiliki peserta didik di abad ke-21 untuk menghadapi tantangan global. Indikator yang menggambarkan kemampuan literasi sains meliputi, mengidentifikasi isu ilmiah, menjelaskan fenomena ilmiah, dan menggunakan bukti ilmiah. Penelitian ini bertujuan untuk mendeskripsikasn kemampuan literasi sains peserta didik melalui E-LKPD berdiferensiasi dengan bantuan wizer.me pada materi bentuk-bentuk energi. Metode penelitian yang diterapkan pada penelitian ini adalah kualitatif dengan pendekatan deskriptif. Subjek penelitian terdiri dari 23 peserta didik kelas X1 SMA Negeri 1 Waigete. Instrumen yang digunakan berupa angket untuk mengklasifikasi gaya belajar masing-masing peserta didik, essaytest sebanyak 3 butir soal untuk mengukur kemampuan sains peserta didik dan wawancara bebas untuk mendalami kemampuan peserta didik. Hasil penelitian menunjukan ketercapaian kemampuan literasi sains sebesar 43,5% dalam predikat “sangat baik”, 30,43% “baik” dan 26,1% “cukup”. Rata-rata pencapaian pada setiap indikator, 86,59% untuk mengidentifikasi isu ilmiah, 84,78% untuk menjelaskan fenomena ilmiah dan 78,26 % untuk indikator menggunakan bukti ilmiah.
YEŞİL LİMANLAR VE PERFORMANSLARI: KUMPORT LİMAN ÖRNEĞİ
Authors: Çelik Yeliz , Yorulmaz Murat
Published: January 2025

Deniz yolu taşımacılığı, büyük hacimli malları tek seferde taşıyabilmesi, hızları nedeniyle daha az yakıt tüketmesi, uzun mesafede daha ekonomik olması ve dolasıyla operasyonel maliyetleri azaltan bir taşımacılık türü olması sebebiyle diğer taşımacılık türlerine göre daha fazla tercih edilmektedir. Ülkeler tarafından daha fazla tercih edilen deniz taşımacılığının en önemli unsurlarından biri de limanlardır. Okyanus ve iç ulaşım hatlarını birleştiren küresel ulaşım ağında kilit nokta olan yüklerin ve insanların bir yerden bir yere ulaşımını sağlayan bünyesinde çeşitli yükleme ve boşaltma donanımları bulunan alt yapı ve üst yapılarıyla çeşitli uygulamaları gerçekleştirebilen teknolojik ve karmaşık bir varlıktır. Yeşil liman ise sürdürülebilirliğe teşvik eden fosil yakıtlara bağımlılığı azaltan kirletici emisyonları minimuma indiren çevre dostu ve rekabetçi bir politika belirleyen bir liman kompleksidir. Bu doğrultuda çalışmada, yeşil liman kavramı irdelenmiş, yeşil limanların performansını etkileyen kriterler literatür araştırması yardımı ile belirlenmiştir. Belirlenen bu kriterlerin ağırlıklandırılması ise sektör raporları ve liman sürdürülebilirlik raporlarındaki sayısal değerler kullanılarak entropi yöntemiyle yapılmıştır. Belirlenen kriter ağırlıkları ile TOPSIS yöntemi kullanılarak Kumport Limanı’nın yıllara göre performans sıralaması oluşturulmuştur. Tüm bu analizlerin sonucunda ‘’Emisyon Miktarı (tCO2/TEU)’’ kriteri en önemli kriter olarak belirlenirken ‘’Yıllık Elleçlenen TEU Miktarı’’ kriteri önemi diğerlerine göre daha az olan kriter olarak tespit edilmiştir. 2020 yılında Kumport Limanı’nın yeşil performansı olarak en üst düzeyde çıkarken 2022 yılında ise performansı ise diğer yıllara kıyasla daha düşük çıkmıştır. Mevcut literatür incelendiğinde, bu çalışma için belirlenen kriterler ile entropi ile TOPSIS metodolojisinin birlikte kullanıldığı ve bir limanın yıllar bazında yeşil liman performans değerlendirilmesinin yapıldığı araştırma tespit edilememiştir. Yapılan çalışma ile literatürde bu eksikliğin giderilmesi beklenmektedir.
Sosyal Hizmet Öğrencilerinde Etik Karar Verme Becerileri: Öz-Şefkat ve İyi Oluş ile İlişkisinin İncelenmesi
Authors: Salman Özlem , Reha Navid
Published: January 2025

Sosyal hizmet öğrencilerinin etik karar verme becerileri konusunda donanımlı olmaları büyük önem taşımaktadır; bu doğrultuda, etik karar verme becerileri ile ilişkili faktörlerin belirlenmesi de oldukça önemlidir. Bu araştırmanın amacı, öz-şefkat ve sosyo-psikolojik iyi oluş faktörlerinin etik karar verme becerileri ile ilişkisini incelemektir. Nicel bir yaklaşımla yürütülen bu çalışmada, orantılı tabakalı örnekleme yöntemiyle ön lisans, lisans ve yüksek lisans düzeyinde öğrenim gören 150 sosyal hizmet öğrencisi araştırma örneklemini oluşturmuştur. Veri toplama araçları olarak Nathanson ve Giffords Sosyal Hizmet Etik Ölçeği, Öz-Şefkat Ölçeği, Psikolojik İyi Oluş Ölçeği ve Sosyo-Demografik Bilgi Formu kullanılmıştır. Bulgular, öğrencilerin öz-şefkatlerinin bilinçlilik alt boyutunun etik ikilem çözme becerisini yordama gücüne sahip olduğunu göstermiştir. Ayrıca, öz-şefkatin öz-sevecenlik ve paylaşım bilinci boyutlarının sosyo-psikolojik iyi oluşu yordayabildiği saptanmıştır. Sosyo-psikolojik iyi oluşun da etik ikilem çözme becerilerini yordadığı belirlenmiştir. Bu doğrultuda, sosyal hizmet öğrencilerine mesleki yetkinlik kazandırmaya yönelik etik beceri eğitiminin yanı sıra, öz-şefkat ve iyi oluşu artırmaya yönelik psiko-eğitim programlarının tasarlanması durumunda etik karar verme becerilerinin de gelişebileceği öngörülmektedir.
A Practical Exploration of Work-Family Balance
Authors: Cooper Joy , Davis Larry
Published: January 2025

This paper analyzes the dimensions of work and family interrole conflicts and modified a process developed by Yavas, Babakus, and Karatepe (2008). The effects of work-family conflict (WFC), family-work conflict (FWC), and stress on intent to stay (ITS) with an organization were analyzed and tested. The paper (a) presents and tests a revised version of the work-family and family-work conflict model and provides support for associated hypotheses; (b) investigates how constructs of FWC, WFC, stress, and ITS to stay with an organization are related in keeping with the model; and (c) presents and discusses the results. Four implications for human resource development practice emerged as well as implications for theory and future research.
Consumption Subsidies Revisited
Authors: Sakuma Itsuo
Published: January 2025

The Japanese government launched the “GO TO Travel” campaign in late July, 2020 amid the COVID-19 pandemic to rescue beleaguered tourism industries by subsidizing travel expenses by 35%. The Cabinet Office, responsible for compiling national account statistics in Japan, determined that these subsidies should be treated as individual final consumption expenditures of the general government. This treatment implies that defrayal of these subsidies by the government was regarded as “consumption subsidies,” by using the term proposed by Jean-Claude Roman in 1985. However, the SNA in its 1993 version and in its 2008 version did not incorporate this concept. So, the Cabinet Office’s treatment is against the present SNA’s recommendations, though she changed the treatment by the end of November 2021. However, it may be worth reconsidering the concept and its treatment. In this paper, the author will review the discussion to clarify the key points involved.
Guyana in 2025: The Confluence of a Possible Dénouement of Its Centuries-Long Territorial Dispute and Its Newfound Oil Wealth
Authors: Sohn Ira
Published: January 2025

In recent years Guyana has been featured in the news disproportionally. This paper begins with a short overview of the country’s vital statistics, followed by a brief review of Guyana’s political and economic pre- and post-independence history, incorporating a synopsis of its longstanding territorial dispute with its neighbor, Venezuela. The paper highlights Guyana’s recent recognition as a potentially large oil-producing nation, whose economy since 2020 has recorded the highest growth rate in the world. In 2023, real Gross Domestic Product (GDP) increased by 33%. With the government committed to deploying the country’s newfound wealth towards modernizing the economy and increasing living standards for all its citizens, Guyana’s vulnerability to the “Dutch disease” and the “resource curse” are discussed along with the technical support provided by the International Monetary Fund and the World Bank who are assisting with the country’s development program.
Comparative Analysis of Regional Economic Conditions in South Texas, Including Business Manager, Local Resident, and University Student Perceptions
Authors: Krueger Thomas M.
Published: January 2025

This report focuses on comprehensive documentation concerning regional economic indicators for Kleberg County, Texas, located in the Coastal Bend Region along the Gulf of Mexico. It is compared to two other South Texas counties, Texas, and United States for perspectives. The benchmark counties were chosen on the basis of their level of tourism, which is a key economic driver in the region. The research is of value to Journal of Applied Business & Economics readers from elsewhere because it is an example of regional economic analysis. Part 1 presents a broad range of demographic data, while Part 2 focuses on economic conditions. Demographic characteristics and economic conditions. Part 3 presents opinions of local business managers, residents and students regarding economic conditions, including preferred government spending. This report builds on the base of economic information is designed to provide decision-makers a valuable economic tool for strategic planning.
My IRA: Making Up Ground or Cashing It in?
Authors: Chen Bing , Stafford Frank P. , Yang Xiaohui
Published: January 2025

We interpret participation in Individual Retirement Accounts (IRAs) in the United States over time from both an economic and socio-behavioral perspective. We report an IRA plateau with about 33% of families aged 30-64 participating during 1999 – 2007. The participation rate has fallen steadily to about 23% in recent years. From an economic perspective, expectations of greater non-pension retirement resources appear to induce a decline in IRA participation. Greater current resources lead to more persistent pension participation. In terms of social factors, we observe notable gender differences in the composition of IRAs.
Strategic Partnerships of Nonprofit Organizations: A Comprehensive Literature Review
Authors: Hoglund Janna , Pann Katrina , Bonds Jill , Beaty Tami , Maranga Kennedy
Published: January 2025

This article draws from in-depth research for the doctoral dissertation “Successful Strategic Partnerships of Nonprofit Organizations: A Case Study.” Serving as a synthesis and sharing some of the content from this dissertation, it offers a comprehensive review of existing literature on the nature and dynamics of strategic partnerships within the nonprofit sector. The article begins by defining strategic partnerships, examining the diverse forms they can take, and exploring the motivations behind their formation. It further delves into the tangible benefits these partnerships can offer and addresses the common challenges organizations encounter in their collaborative efforts. Additionally, key success factors that enhance the effectiveness of these alliances are highlighted, as well as insights into why some partnerships fail to yield intended outcomes. With a particular emphasis on partnerships led by nonprofit leaders, this review underscores how thoughtful and well-constructed collaborations can amplify the missions of nonprofit organizations, streamline resource usage, and generate a broader community impact.
Analysis of the General Aviation Jet Industry: Competition, Concentration, and Forecasts With an Eye on Labor Markets
Authors: Jacobs Jesse , Catlett Rob
Published: January 2025

This paper examines the global production and delivery of business jets, focusing on trends and shifts in industry concentration using the Herfindahl-Hirschman Index (HHI). After analyzing the concentration trend, we use ARIMA models to forecast production and industry structure through 2026 and estimate the impact of changing concentration on employment. Although estimates indicate increasing concentration in the large jet sector, a potential increase in deliveries and growing GDP could offset the higher HHI. The findings offer valuable information for policymakers and analysts interested in capital-intensive industries while contributing to broader discussions on market competition and labor dynamics.
Fintechs and Banking: A Note on Neobank Risks
Authors: Brown Jason , Casey K. Michael , McMurtrey Mark
Published: January 2025

The fintech industry has made rapid inroads into banking in the last several years. Pundits tout that it will improve efficiencies while giving consumers broader choices in developing their banking portfolios. Others posit that it will erode bank profitability and that its success is tied to monetary policy. Our research focuses on an overlooked aspect of fintech: neobanks, sometimes called a challenger bank, that allow customer access to apps and software that streamline online and mobile banking. This paper will cover a brief history of fintechs, fintech advantages, and finally, discuss some of the risks of neobanking.
Valuation Considerations of Stock Based Compensation: A Case Study of Semiconductor Firms
Authors: Russell Engel  , Lyons Bridget
Published: January 2025

Equity research analysts and investors remain divided on the treatment of stock-based compensation (SBC) in firm valuation, particularly in discounted cash flow (DCF) and earnings multiples techniques. Many firms and analysts exclude SBC, viewing it as a non-cash expense, while others argue this leads to overvaluation. SBC usage is especially high in the tech sector. This study examines five large semiconductor firms, analyzing SBC levels, its treatment in adjusted earnings, and its impact on share dilution, valuation multiples, and free cash flow calculations. Findings indicate that SBC treatment significantly affects valuation, particularly within the semiconductor industry.
Evaluating Technical Trading Strategies in US Stocks: Insights From Data-Snooping Test
Authors: Wang Yifei , Chen Yidong , Tian Hongyu , Wayne Zane
Published: January 2025

Our comprehensive evaluation examines the in-sample and out-of-sample effectiveness of technical trading strategies for Apple Computer Inc (AAPL), Microsoft Corp (MSFT), and Nvidia Corp (NVDA) over the period from January 2000 to December 2022. Utilizing advanced methods such as reality checks and stepwise tests, we address the potential data-snooping bias—a scenario where apparently profitable strategies might arise by chance rather than through genuine predictive accuracy. Despite rigorous analytical techniques, our findings indicate an inability to identify any technical trading strategies that yield consistent profits in both the in-sample and out-of-sample periods. Further analysis, with a specific cutoff established in February 2016 and incorporating corrections for data snooping, consistently demonstrates the unprofitability of these strategies. This highlights a significant challenge in financial markets: the intrinsic difficulty in identifying technical trading strategies that can consistently produce profitable outcomes over time. Our conclusions underscore the complexities inherent in technical analysis and the substantial obstacles in deriving actionable insights for stock market trading based on technical trading frameworks.
Macro-effecten in het aansprakelijkheidsrecht
Authors:   , van Deursen Stijn
Published: January 2025

The role and position of the judge are constantly evolving. Due to dissatisfaction with the (lack of) solutions from the Dutch government to societal issues, interest groups are increasingly using the courtroom as an arena to achieve (their desired) societal changes. Consider recent cases on climate change, the export of aircraft components by the Netherlands to Israel, or the Dutch asylum system. Such cases have far-reaching societal consequences. At the same time, judges are expected to complement the legislature by further developing the law — for example, by interpreting rules and filling in open norms. People and businesses subsequently adjust their behavior based on the results of such judicial lawmaking. Here too, the consequences of a judicial decision extend beyond the individual dispute.

As a result of the foregoing, judges are increasingly confronted with the potential societal consequences of their rulings. In such cases, macro consequences arise. But what should judges do with such potential effects of their judgments? If a judge wishes to consider macro-effects in their decision-making, this raises complex questio. For instance, how can they obtain relevant information beyond the parties involved when they have to base their judgment solely on the input of the litigating parties? And how far can they go in considering macro-effects without encroaching on the political domain?

This research aims to provide judges with a compass to navigate between the domains of society, the litigating parties, and politics in tort cases where macro consequences may arise
Prediction of Akute Kidney Injury Development in Critically Ill Septic Patients Based on NGAL Determination
Authors: Klementa V , Petejova N , Zadrazil J , Horak P , Proskova J , Langova K , Klementova O , Kanova M , Martinek A , Sigutova R , Stejskal D
Published: January 2025

Acute kidney injury (AKI) is a consequence of several diseases that can severely damage kidney function. It is a frequent complication of hospitalization and very common in critically ill patients because of other serious illnesses, such as septic conditions. New diagnostic options, including renal biomarkers, may help in early diagnosis. Our study included 46 patients, 31 with AKI and 15 without AKI on admission. Blood samples were collected on the first, fourth, and seventh days of treatment, and in addition to basic biochemical parameters, neutrophil gelatinase-associated lipocalin (NGAL) levels in serum were also examined. Data from the first and seventh day were used for statistical analysis. On the first follow-up day, NGAL values were categorized according to an optimal cut-off value of 290 µg/l. We demonstrated that if NGAL levels were higher, the risk of renal injury increased approximately 16 times. Other results showed that NGAL levels were moderately correlated with serum creatinine (r = 0.613, p < 0.0001), procalcitonin (PCT) (r = 0.627, p < 0.0001), and AKI stage (r = 0.589, p < 0.0001). There was also a significant positive correlation with SOFA (Sequential Organ Failure Assessment) score (r = 0.395, p = 0.007). Early diagnosis and treatment are crucial in managing AKI and preventing further kidney damage. NGAL levels can increase within a few hours after injury, making it a useful tool for early AKI detection and diagnosis.
ECO-ENZYME SUPPORTS HOUSEHOLD ORGANIC WASTE MANAGEMENT IN ANGGANA VILLAGE KUTAI KARTANEGARAEAST KALIMANTAN DI DESA ANGGANA KUTAI KARTANEGARAKALIMANTAN TIMUR
Authors: Supriningrum Risa , Siska Dea , Thesya Bella Micha , Putri Nabilla Julia Deswita
Published: January 2025

Sampah masih menjadi permasalahan masyarakat Indonesia. Pengelolaan sampah oleh pemerintah belum berjalan dengan baik, kurang maksimalnya pengelolaan menjadikan sampah tidak memiliki nilai. Di sisi lain masyarakat kurang memiliki kesadaran untuk mengelola sampah , sehingga nilai guna dari sampah itu sendiri tidak ada. Untuk itu dilakukan kegiatan pengabdian masyarakat yang bertujuan mengajak masyarakat meningkatkan kesadaran akan pentingnya mengelola sampah secara mandiri atau kelompok, terutama sampah organik rumah tangga melalui pembuatan eco enzim. Eco enzim merupakan larutan fermentasi dari limbah organik, dengan sejuta manfaat. Sasaran kegiatan ini adalah ibu PKK desa Anggana, Kutai Kartanegara, Kalimantan Timur. Metode yang digunakan adalah penyuluhan dilanjutkan demonstrasi pembuatan eco enzim. Hasil dari kegiatan adalah terjadinya peningkatan pemahaman peserta terhadap eco enzim. Peserta akan melakukan pengelolaan sampah organik rumah tangga secara mandiri ataupun berkelompok.
Edukasi Bahaya Bahan Kimia dan Workshop Pembuatan Sabun Cuci Piring dari Lidah Buaya (Aloe vera)
Authors: Imtihani Hilya Nur , Prasetya Rahmad Aji , Arifiyana Djamilah , Wahyuni Putri
Published: January 2025

Lidah buaya (Aloe vera) memiliki banyak manfaat, salah satunya karena mengandung saponin, yang memiliki sifat membersihkan dan antiseptik. Lidah buaya dapat digunakan untuk membuat sabun yang dapat membunuh bakteri dan melembutkan kulit. Tujuan dari Kegiatan Pengabdian Masyarakatkali ini adalah untuk memberikan workshop dan informasi tentang bahaya bahan kimia dan cara pembuatan sabun dari lidah buaya sebagai antiseptik alami. Kegiatan dilakukan di daerah Gubeng Surabaya dengan 32 peserta. Setelah dilakukan pretest dan posttest, data diolah secara statistik dan didapatkan Asymp. Sig. (2-tailed) = 0,000 (<0,05) artinya terdapat perbedaan antara nilai pretest dan posttest artinya dapat dikatakan bahwa pemaparan materi mempengaruhi wawasan warga.
Self-reported food allergies in early childhood in rural Australia
Authors: Weber Heinrich C. , Bassett Gaylene L. , Sohal Sukhwinder S. , Prior Sarah J.
Published: January 2025

Introduction

The prevalence of childhood food allergies is escalating, with Australia notably affected. Research primarily originates from urban centres, leaving rural areas underrepresented. This study examines food allergy prevalence among 1,052 grade 1 and 2 children in regional and rural Tasmania.

Method

Diagnosis relied on validated parental self-reports and identified anaphylaxis by symptoms coupled with breathing difficulties.

Results

The median participant age was 8.1 years. Food allergy prevalence stood at 8.5% (n = 89), with cow's milk, peanuts/nuts, and eggs as primary allergens. Anaphylaxis prevalence was 18.0% (n = 16) of participants with food allergies, predominantly triggered by peanuts/nuts, eggs, and shellfish.

Conclusion

The study delves into reactions to non-allergenic foods and associated avoidance leading to increased morbidity. This report contributes valuable insights to the insufficiently documented landscape of food allergy prevalence, shedding light on a poorly described aspect.
Model-based fed-batch cultivation of Viola odorata plant cells exhibiting antimalarial and anticancer activity
Authors: Babu R. , Veeramani Manokaran , Aadinath Wallepure , Muthuvijayan Vignesh , Singh Shailja , Srivastava Smita
Published: January 2025

Introduction

Viola odorata is a medicinal plant used in the indigenous systems of medicine in India, to treat respiratory tract disorders. V. odorata natural plant source is limited in availability. Bioprocess principles can be applied to develop sustainable methods for the commercial production of high-quality V. odorata plant biomass.

Methods

To this effect, the in vitro culture conditions of V. odorata were rationally optimized to increase the biomass production up to 21.7 ± 0.8 g DW L−1 in 12 days in shake flasks. In the current study, a modified stirred tank reactor and a balloon-type bubble column reactor were used to improve the biomass production at the batch reactor level. Sufficient nutrient feeding strategies were developed using first principle-based mathematical modelling to overcome substrate inhibition and achieve higher cell density in the reactor. In addition, bioreactor-cultivated biomass extracts (aqueous/alcoholic) were tested for various bioactivities like hemolytic, cytotoxic, anti-inflammatory, and antiplasmodial.

Results

Experimental validation of the fed-batch model-predicted strategy resulted in a two-fold enhancement in biomass production (32.2 g DW L−1) at the bioreactor level. Biomass extracts showed no hemolytic activity up to 4 mg mL−1 concentrations. Further, the stirred tank cultivated biomass extract displayed cytotoxicity against Caco2 - colon carcinoma cell lines, exhibiting an IC50 of 1.5 ± 0.1 mg mL−1. In vitro experiments also indicated the anti-inflammatory property in the bioreactor cultivated plant biomass extracts. As a new application, the biomass extracts also demonstrated up to 80% inhibition of malarial parasite growth in vitro. Additionally, when administered alongside artesunate (1.8 mg kg−1d−1), the plant extracts (400 mg kg−1d−1) effectively controlled parasite growth in vivo.

Discussion

It is to be noted that a first report on fed-batch cultivation of V. odorata cell suspension culture in lab-scale bioreactors and on the antiplasmodial activity of the V. odorata plant extracts. Overall, the bioactive potential of the in vitro-generated plant biomass extracts is similar to that in the natural plant biomass extracts.
Coordinating multiactivity transitions in dance rehearsals: spatial configurations and instructional practices
Authors: Krug Maximilian
Published: January 2025

This study explores the mechanisms behind activity transitions in dance rehearsals, focusing on how participants manage multiactivities in instructional situations. The research uses multimodal conversation analysis to examine the spatial configurations and interactional practices of a professional choreographer and two nonprofessional dancers. The analysis reveals how participants create activity transitions, mobilize resources, and maintain continuity across activities, emphasizing the crucial role of spatial positioning and timing in managing transitions. By maintaining one activity while introducing others, participants effectively coordinate multiple activities without disrupting the rehearsal’s flow. The findings contribute to an understanding of multiactivity in social interactions and offer practical insights for instructional practices in dance and other embodied activities.
Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study
Authors: Wang Kaiwen , Lou Yu , Tian Shunjie , Tao Zhihui
Published: January 2025

Objective

The aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study.

Methods

Based on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testosterone, estradiol, and IBD in a European population, we performed two-sample bidirectional MR analyses using single nucleotide polymorphisms (SNPs) as instrumental variables. We used inverse variance weighting (IVW), weighted median, weighted mode, and MR-Egger to assess bidirectional causality between sex hormones and IBD.

Results

There was no causal relationship between sex hormones and IBD in women (P > 0.05), and there was a causal and positive correlation between SHBG and testosterone and IBD in men.The OR for SHBG was 1.22 (95% CI: 1.09-1.37, P = 0.0004), and for testosterone was 1.20 (95% CI: 1.04-1.39, P = 0.0145).IBD did not significantly interact with female sex hormones but resulted in a decrease in SHBG (OR = 1.02, 95% CI: 1.00-1.04, P = 0.0195) and testosterone (OR = 1.01, 95% CI: 1.00 -1.02, P = 0.0200) in men.

Conclusion

There is no causal relationship between female sex hormones and IBD, but male SHBG and testosterone are positively correlated with the risk of IBD and IBD promotes elevated levels of SHBG and testosterone in males, suggesting that sex hormones play different roles in IBD patients of different sexes.
Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference
Authors: Golounina Olga , Minniakhmetov Ildar , Salakhov Ramil , Khusainova Rita , Zakharova Ekaterina , Bychkov Igor , Mokrysheva Natalia
Published: January 2025

Molecular therapy uses nucleic acid-based therapeutics agents and becomes a promising alternative for disease conditions unresponsive to traditional pharmaceutical approaches. Antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) are two well-known strategies used to modulate gene expression. RNA-targeted therapy can precisely modulate the function of target RNA with minimal off-target effects and can be rationally designed based on sequence data. ASOs and siRNA-based drugs have unique capabilities for using in target groups of patients or can be tailored as patient-customized N-of-1 therapeutic approach. Antisense therapy can be utilized not only for the treatment of monogenic diseases but also holds significant promise for addressing polygenic and complex diseases by targeting key genes and molecular pathways involved in disease pathogenesis. In the context of endocrine disorders, molecular therapy is particularly effective in modulating pathogenic mechanisms such as defective insulin signaling, beta-cell dysfunction and hormonal imbalances. Furthermore, siRNA and ASOs have the ability to downregulate overactive signaling pathways that contribute to complex, non-monogenic endocrine disorders, thereby addressing these conditions at their molecular origin. ASOs are also being studied worldwide as unique candidates for developing therapies for N-of-1 therapies. The sequence-specific ASOs binding provides exceptional accuracy in N-of-1 approaches, when the oligonucleotide can be targeted to a patient’s exact mutant sequence. In this review we focus on diseases of the endocrine system and discuss potential RNA-targeted therapeutic opportunities in diabetes mellitus, including monogenic beta cell diabetes, and obesity, including syndrome obesity and monogenic obesity, as well as in non-monogenic or complex endocrine disorders. We also provide an overview of currently developed and available antisense molecules, and describe potentials of antisense-based therapeutics for the treatment of rare and «ultrarare» endocrine diseases.
A holistic approach is needed for women with an inflammatory arthritis in the different phases around pregnancy; the results of the CAPRI study
Authors: van Steensel – Boon A. J. , Wintjes H. M. , Röder E. , Smeele H. T. W. , Kranenburg - van Koppen L. J. C. , Dolhain R. J. E. M. , Perez-Garcia L. F.
Published: January 2025

Introduction

Women with inflammatory arthritis (IA) face significant challenges throughout preconception, pregnancy, and postpartum phases, including concerns about disease management and medication safety. The Reproductive Rheumatology care pathway at Erasmus University Medical Center integrates specialized care from rheumatologists and specialized nurses to address both medical, nursing, practical and emotional needs during these phases. This study evaluates patient satisfaction, identifies unmet needs, and explores opportunities for enhancing support within this integrated care model.

Methods

This was a cross-sectional study. We designed a customized questionnaire for women 18 years and older who were treated following the Reproductive Rheumatology care pathway and had given birth between 2019 and 2021. These women were invited to fill in the questionnaire. The survey assessed satisfaction with care, challenges experienced, and information needs across preconception, pregnancy, and postpartum phases. Descriptive statistics and paired t-tests were used for data analysis.

Results

Participants reported high satisfaction with care, rating rheumatologists an average of 8.8/10 and specialized nurses 9.2/10. While 78.9% experienced no major issues, some faced problems such as managing disease flares and difficulties around conception. Information needs varied by phase: preconception needs focused on medication safety and fertility, while pregnancy and postpartum concerns included disease management and emotional support. Specialized nurses were pivotal in offering personalized care and practical advice.

Conclusion

The integrated Reproductive Rheumatology care pathway effectively supports women with IA through their reproductive journey. Despite high satisfaction, improvements could be made in personalized care and addressing challenges related to confidence and help acceptance. Future research should investigate the long-term impact of such care pathways on reproductive outcomes and patient well-being.
Bibliometric analysis of research in ethical concerns and dilemmas of digital mental health care in the last two decades
Authors: Sharma Poonam , Wagani Rekha , Varghese Mahima Anna
Published: January 2025

Introduction

Digital mental health care system includes the interventions delivered via digital technologies, such as mobile apps, websites, or virtual reality (VR). A recent upsurge in the digital mental healthcare care services has been observed in the last 5 years. With its core advantage of reaching the unreached, wider coverage, cost and time effectivity, all eyes are on the digital mental health care system. It is definitely a mechanism to cater rising prevalence of mental health concern, stigma towards mental health, accessibility and cost and uplift the psychological wellbeing. Success of the digital mental health care system has been researched world-wide. However, the same is not unaffected by the ethical concerns.

Methods

This study aims to perform a comprehensive bibliometric analysis of scholarly articles on ethical concerns and dilemmas of digital mental health care by utilizing data extracted from the Scopus database from 2000 to 2024 by analysing 123 research articles. Statistical descriptive analysis in combination with performance analysis and co-word analysis was used to understand the research trends, leading countries and country collaborations studying ethical concerns related to digital mental healthcare.

Result and discussion

The first publication appeared in 2000 with zero research till the year 2005. In this decade till 2010 we can observe only 4 publications. Consistent publishing started trending upward through 2018, observing the largest increase during pandemic in 2020 and onwards constituting 100 publications. The United States of America is the leading country studying ethical dilemmas in Digital Mental healthcare, with 42 papers followed by United Kingdom with 23 publications. The most influential peace of research with 490 citations is article co-authored by Barak et al. (2009), which is defining internet-supported therapeutic interventions and related concerns. BMJ Open is noted as the leading journal which is publishing issues concerning Digital Mental Healthcare with 18 publications, followed by Frontiers in Psychiatry and JMIR Mental Health. Analyses reflects that the top cited articles on Digital Mental healthcare are specifically directed on bringing out some of the key concerns of data privacy, emergency response, therapist competency and consent which requires appropriate handling Otherwise they may be cause of distress to client and question the trustworthiness of the Digital Mental Health Care system.

Conclusion

The concerns brought out through this bibliometric analysis could be important guiding principles for online mental health services. Alongside, mental health professionals operating online must have orientation on the ethical concerns surrounding online mental healthcare.
Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model
Authors: Hornikova Tereza , Jelinkova Anna , Jiraskova Zakostelska Zuzana , Thon Tomas , Coufal Stepan , Polouckova Andrea , Kopelentova Eliska , Kverka Miloslav , Makovicky Peter , Tlaskalova-Hogenova Helena , Sediva Anna , Schwarzer Martin , Srutkova Dagmar
Published: January 2025

Background

The dual allergen exposure hypothesis states that sensitization to food antigens occurs through a damaged skin barrier in individuals with no previous oral tolerance to certain foods. However, the resulting allergic reaction could depend on factors such as the host’s genetic predisposition as well as the skin and gut microbiota.

Methods

Specific-pathogen-free BALB/c and C57BL/6 and germ-free (GF) BALB/c mice were epicutaneously sensitized with ovalbumin (OVA) via dorsal tape-stripped skin and challenged with OVA by intragastric gavage. The development of food allergy (FA) symptoms, the Th2 and mast cell immune response and differences in the skin and gut microbiota were investigated.

Results

BALB/c mice, but not C57BL/6 mice, showed severe clinical signs of FA (hypothermia, diarrhea) as well as a stronger serum antibody response and Th2 cytokine secretion in the spleen and jejunum after OVA-treatment. The increased mast cell count correlated with higher MCPT-1 production and histidine decarboxylase mRNA expression in the jejunum of these mice. The 16S rRNA sequencing analysis revealed lower abundance of short-chain fatty acids producing bacteria in the gut microbiome of OVA-treated BALB/c mice. Changes in the β-diversity of the gut microbiome reflect both the genetic background as well as the OVA treatment of experimental mice. Compared to SPF mice, GF mice developed more severe anaphylactic hypothermia but no diarrhea, although they had a higher mast cell count, increased MCPT-1 production in the jejunum and serum, and increased arachidonate 5-lipoxygenase mRNA expression.

Conclusions

We show that the BALB/c mice are a mouse strain of choice for model of adjuvant-free epicutaneous sensitization through the disrupted skin barrier and following food allergy development. Our results highlight the significant influence of genetic background and microbiota on food allergy susceptibility, emphasizing the complex interplay between these factors in the allergic response.