bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH KOMPENSASI TERHADAP KINERJA GURU PADA YAYASAN PENDIDIKAN WASKITO
Authors: Gandung Muhammad
Published: May 2019

ABSTRAKTujuan penelitian untuk mengetahui kompensasi yang diberikan Yayasan Pendidikan Waskito serta untuk mengetahui kinerja guru Yayasan Pendidikan Waskito dan seberapa besar pengaruh kompenasi terhadap kinerja guru Yayasan Pendidikan Waskito. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif hal ini dimaksudkan untuk menghitung dari angket data kompensasi yang diterima guru sebagai variabel bebas (X) yang sudah diketahui dan menghitung angket data kinerja karyawan sebagai variabel tetap (Y) yang belum diketahui dari hasil angket yang disebarkan ke guru, salah satu metode yang digunakan oleh penulis adalah dengan menggunakan model-model matematika dan statistik. Dengan mentabulasi perolehan kuesioner yang kemudian menggunakan analisis korelasi product moment, Validias, Reabilitas, Determinasi dan Uji Signifikansi. Berdasarkan hasil yang diperoleh dan sudah diolah terlebih dahulu melalui perhitungan korelasi antara kompensasi terhadap kinerja karyawan diperoleh nilai rxy determinasi sebesar 0,708 dengab korelasi determinasi sebesar 50% sedangkan 50% dipengaruhi oleh faktor lain. Kemudian dari perhitungan uji keberartian Koefisien Korelasi (Uji-t) diperoleh nilai t hitung = 3,304 dan t tabel = 2,000. Ternyata t hitung > t tabel. Dengan demikian Ho ditolak, artinya terdapat hubungan yang berarti antara Kompensasi dan Kinerja Guru. Berdasarkan hasil tanggapan responden yang diperoleh dalam penelitian maka dapat diketahui bahwa kompensasi yang diberikan oleh Yayasan Pendidikan Waskito telah dilaksanakan dengan baik sehingga kinerja guru semakin membaik. Kebijakan tersebut hendaknya dipertahankan oleh perusahaan agar semangat kerja para guru tetap tinggi sehingga tujuan Yayasan Pendidikan Waskito dan keinginan para guru dapat tercapai dengan baik. Kata kunci : Kompensasi, Kinerja
Manufacture of a fast neutron detector using EJ-301 liquid scintillator
Authors: Phan Chuan Van , Nguyen Hoa Duc , Nguyen Hai Xuan , Nguyen Tan Duy
Published: May 2019

A fast neutron detector using the EJ- 301 scintillator was manufactured for study on detecting fast neutrons and gamma-rays. Detector characteristics include the energy linearity, the efficiency response and the neutron/gamma discrimination were guaranteed for neutron detection in the energy range from 50 to 3000 keVee. The ability discrimination of neutrons/gamma-rays of the detector was evaluated by the charge comparison (CC) method using an 252Cf source. The total efficiencies when measured on 22Na, 137Cs, 60Co and 252Cf sources were obtained 17.8%, 3.9%, 9.8% and 14.8%, respectively. The Figure of Merit (FoM) values of CC method were 0.4–1.55 for the range of energy 50–1000 keVee (keV electron equivalent).
Impacts of the thickness on the electron mobility of gallium and hydrogen co– doped zinc oxide thin films
Authors: Pham Anh Thanh Tuan , Hoang Dung Van , Nguyen Truong Huu , Phan Thang Bach , Tran Vinh Cao
Published: May 2019

this work, impacts of the thickness on electron mobility of Ga and H2 co-doped ZnO (HGZO) thin films were investigated. The HGZO films were prepared on glass substrate by using magnetron sputtering from ceramic Ga-doped ZnO (GZO) target in the gas mixture of argon and hydrogen. Based on the Hall measurement, the mobility enhanced fastly from 44.6 to 53.4cm2/Vs with the increasing thickness from 350 to 900 nm, then tends to be saturated at ~55cm2/Vs with further thickness. Most of the films achieve the mobility of >50cm2/Vs, which is very high value for sputtered TCOs thin films. The thicknessdependent mobility is explained in term of grain boundary scattering. The improvement of crystalline quality reduced grain boundary scattering, which lead to the fast increase in mobility of the films with 350–900nm in thickness. When the thickness increased more than 900nm, however, the appearance of many defects increased scattering centers and saturates the mobility. Furthermore, the results showed the HGZO films with optimum thickness of 800nm obtained low resistivity (5.3 10-4􀁛cm), high average transmittance (83.3%) in the wide wavelength range of 400–1100nm, and the highest figure of merit (10.3 103􀁛-1cm-1) corresponding to high mobility (51.1cm2/Vs).
Fireproof behavior of polyurethane foam based on waste poly(ethylene terephthalate) using aluminum hydrogen phosphonate flame retardant
Authors: Pham Tram Tran Thi Ai , Hoang Quy Thi Dong
Published: May 2019

Poly(ethylene terephthalate) is a widely used polymer in the blow molding bottles, electron industry, texiile industry and can be recycled to synthesize new materials such as polyurethane foam (PUf) and unsaturated polyester (UP). One of them, PUf has many desirable properties such as low thermal conductivity, low density, excellent dimensional stability, high strength-to-weight ratio, low moisture permeability and low water absorption. However, PUf is a highly flammable material. In this study, aluminum hydrogen phosphonate (AHP) was synthesized in order to investigate their flame retarding performances for PUf. UL-94 V-1 was obtained at 15 phr loading of AHP. The incorporation of flame retardant increased the fireresistant property of PUf. In addition, other properties such as density, foam structure, and water and moisture absorption were also investigated.
Hydrothermal synthesis of gold nanoparticles and metal organic framework hybrid structure
Authors: Nguyen Hien Thi Thu , Le Hai Thi , Nguyen Trang Thi Minh , Nguyen Hien Minh , Pham Thi Tan
Published: May 2019

We report a hydrothermal synthesis of a hybrid structure between gold nanoparticles and a metal organic framework, ZIF-8 (abbreviated as Au@ZIF-8). Au nanoparticles encapsulated in polyvinylpyrrolidone (PVP) was employed as seeds to grow the framework of ZIF-8. We controlled the position and concentrations of Au nanoparticles on ZIF-8 crystal by adjusting the volume of Au nanoparticles dissolved in DI water during the growth of ZIF-8. Morphology, structure, distribution of the hybrid structure were investigated by transmission microscope, powder xray diffraction, and diffuse reflectance UV-Vis spectroscopy. We tested out catalytic properties of Au@ZIF-8 through the reaction of 2-nitrophenol and NaBH4.
Investigation a clean up procedure for chlorophenols in soil by ultrasonic and solid phase extraction
Authors: Doan Truong Vinh , Le Vinh Xuan , To Hien Thi , Ngo Thuan Thi
Published: May 2019

Chlorophenol is a group of toxic and presistent compounds in soil. Investigation on an appropriate procedure is very important to quantify all chlorophenol congeners. All parameters in ultrasonic combined with soild phase C18 extraction (SPE_C18), and then high performance liquid chromatography/ UV detector were selected and optimised. Various soil samples contaminated by chlorophenols containing from 0.67% to 2.36% of organic matter and clay content from 1.37%–22.30% were selected and examined. The results showed that a group of 3–chlorophenol, 3,4–dichlorophenol, 3,5–dichlorophenol, 3,4,5– trichlorophenol, 2,3,4,6–tetrachlorophenol, 2,3,4,5– tetrachlorophenol, pentachlorophenol contaminated in soils has high recovery efficiencies (>70%) with low standard devitation (<7%). This method is suitable to analyze chlorophenol in soil with limit of detection (LOD) about 0.2mg/kg and limit of quantification (LOQ) about 1mg/kg. This research is helpful in risk assessment of chlorophenols contaminated in soil and suitable in Vietnam.
Population aging and inhabitant consciousness of community development: a case study of the rural area in Thua Thien Hue Province, Vietnam
Authors: Bui Thu Thi , Kazunobu Tsutsui , Do Huong Thi Viet
Published: May 2019

Population aging, which is a global phenomenon, has strongly impacted the social lives of many societies around the world. In which, Japan and Vietnam are two of the twenty countries with the largest older population in the world. The “Kaso”- depopulation, has been occurring in rural Japan since the 1960s and has had negative impacts on community development. Vietnam in general, and Thua Thien Hue Province in particular is revealed to be in the beginning period of the “aging phase” - one of the Kaso signs. This paper attempts to clarify (1) how the extent of “Kaso” in Japan occurs in the study area of Vietnam; and (2) how is the inhabitant consciousness on daily life, socioeconomic development status and the concern of local people on the future development of rural community in context of projected population aging. Based on preliminary typology analysis of the demographic statistics (total population, aging population structure) of Thua Thien Hue at the commune level during the period of 1989-2012, two rural communes with aging population characters were chosen for further analysis through household questionnaires. The research result demonstrated that there has been similar to the initial situation of Kaso in rural Japan. However, the deep analysis result indicated that the presence of rural people’s negative consciousness of community development is not strong. Those preliminary results enable to emphasize significant importance on providing implicit information on the negative consciousness of rural people regarding the future of rural Vietnam.
Rural Sustainability in the Face of Climate Change: Consultation and Adaptation in Australia’s South West Corner
Authors: Jones Roy
Published: May 2019

The Margaret River region is within a biodiversity ‘hot spot’ and is an agricultural region famous for its premium wine production and wine, gastronomic and ecotourism. These activities are vulnerable to climate change, especially to reductions in rainfall and runoff. The region has experienced demographic growth as the wine and tourism industries have expanded, and as an educated and affluent population of retirees, second home owners, ‘electronic cottagers’ and alternative lifestylers has moved into the area. Two projects, a local study as part of a national evaluation of the adaptation of tourist areas to climate change and a more focused identification of vulnerable locations and activities were supported by local government, business and community organisations and several adaptive strategies were identified. The success of these projects can in part be attributed to the relatively high levels of both education and environmental awareness possessed by the local population as a matter of happenstance. Nevertheless, the original contention of this paper is that these initiatives also allow communities like Margaret River to take on the role of front-runners, providing demonstrations and learning opportunities on how to manage the transition to sustainability and guidance on how such methods might be adapted in other rural areas facing the challenges of climate change.
Spatial and socio-economic transformation of transhumance in gerger district (Southeast Turkey)
Authors: BAKIRCI Muzaffer
Published: May 2019

Turkey has gone into a rapid process of transformation especially starting with the 80s. Un on trolled migration from rural areas to urban areas since this date, not only led rural areas to be emptied to a great extent, but also caused emergence of various structural problems in urban areas. One of the forms of living in Turkey that were affected the most by the change and transformation experienced in rural areas is transhumance. Seminomadic animal husbandry carried out in almost all regions of Turkey and the lifestyle related to this face radical changes. The Gerger district, located in southeast Turkey, is one of the areas that experienced this process of change most noticeably. Transhumance, which has been carried out for centuries here continuously, faces significant spatial, economic and socio-cultural transformations. In spatial transformation, regression of animal husbandry activities based on natural environment conditions and occasional emergence of agricultural production become prevalent, while significant differentiations take place in types of residences. Animal husbandry, which used to be a main economic activity in the past, disappeared in dramatic rates and is almost no longer an activity that brings income, which indicates economic transformation; again, loss of influence of a set of social rules that used to be followed precisely and disappearing of some traditions indicate sociocultural transformation.
Festival related to water Southeast Asia
Authors: Le Diep Thi Ngoc
Published: May 2019

For agricultural countries, people's lives depend entirely on the chance of nature, especially on water. Water is therefore an important sacred element for the farmer. Southeast Asians see rain - water as the most important factor in their crops, their lives, and water. Rain is also the manifestation of the heart of heaven, of the gods. So far, agricultural peoples have formed beliefs to pray for the power of the gods to support human beings. This belief is expressed through rituals, waterrelated festivals, typical of the festival praying rain down and pray for the sun. On the basis of the intimate relationship between the ecological environment and the festival, this article focuses on research festivals related to water in Southeast Asia to contribute to the deconstruction of sacred rituals during festival. Through rituals during the festival, human behavior can be seen in relation to the natural environment of the rice agriculture farmers. The main research method of this article: system method - structure, comparison method, interpretation method; Theoretical approach of the paper is ecological theory and structural theory.
Space and aboriginal Australians in Urban Areas
Authors: Nguyen Tin Ly Trong
Published: May 2019

Space is regarded not simply as a backdrop against which social processes are played out, but also as a means for the realisation of interest and power relations, and an outlet of a community’s identity, which in turn shapes that identity. In the case of Aboriginal Australians, who live in the land that is originally of their ownership but later largely occupied by European people, the utilisation of space for indicating their presence, therefore promoting their interest, and space influence upon them, can be seen in Australian urban areas. The Aboriginal might increase their visibility variously in residential areas, at their own buildings, or via drawings along roads in their settlements. These efforts notwithstanding, the marking of space by the white people is seemingly dominant, and the Aboriginal are prone to think that they are excluded in some measure from urban social activities.
PTM AND CELL CYCLE GATING MECHANISMS DEVIATED FOR PROGRESSION OF CANCER
Authors: Beeram Eswari
Published: May 2019

Post translational modifications like phosphorylation, Glycosylation and ADP ribosylation serves as biomarkers and are mainly involved in regulation of signalling pathways, cell polarity and cell cycle progression. So, this review helps in finding the biomarkers in understanding of cancer genome and also the deviations observed in gating mechanisms. Mucin 3 is mainly involved in EMT transition and Phosphorylation is also required for effective complex formation between catenin and cadherin. Hyaluron acts as medium for the tumors cells and aids in their movement and responsible for metastatic development. Epigenetic modification like methylation is helpful for cancerous genome to develop additional mutations for survival of the genome.

Key words: Cyclin D, PTMs, Gating, Glycosylation, Phosphorylation.
ASSESSMENT OF MEDICATION EFFICACY ON DETERMINANTS OF PSYCHIATRIC ILLNESS AMONG DIABETES MELLITUS PARTICIPANTS
Authors: Alex Akza K , DR Bharathi , GR Nataraj , Mathew Adarsh , SM Tejaswini
Published: May 2019

Introduction: The prevalence of Diabetes Mellitus (DM) among adults has been increased considerably across the globe, and has contributed a substantial proportion in annual mortality rate. Diabetes and psychiatric disorders are having such an interface that they both influence each other in several ways.

Objectives: The study was conducted to assess the prevalence, determinant factors, prescription pattern, efficacy and adverse reactions in diabetic patients associated with psychiatric illness in a tertiary care hospital.

Materials and Methods: A prospective observational study was carried out for a period of ten months in General Medicine and Psychiatric Department, Basaveswara Medical College Hospital and Research centre, Chitradurga.

Results: In this study, a total of 101 diabetic patients with or without co-morbidities were enrolled in the study. Among them, 27 in-patients were associated with psychiatric illness which was considered as co-morbid condition. The prevalence of psychiatric illness with diabetes mellitus was found to be 26.7% which is highly significant with the p-value (0.00). A higher prevalence was noticed with age group 41-50 years and with male gender. The common determinant factors of psychiatric illness in diabetic patients were being women, having no income, being at the age of menopause, having no physical activity, being illiterate and being single or widowed.  Among the anti-diabetic drug prescriptions, there was a higher percentage of use of insulin and the most commonly prescribed drug was combination of Glimepride + Metformin (sulfonylurea and biguanide). The most commonly prescribed anti-psychotic drugs were chlordiazepoxide and alprazolam. Conclusion: The study reveals a high prevalence of psychiatric illness in diabetic patients with determinant factors of psychiatric illness in diabetic patients were being women, having no income, being at the age of menopause, having no physical activity, being illiterate and being single or widowed.

Key Words: Prevalence; Determinant factors; Diabetes mellitus; Psychiatric illness
Intratumoral Morphological Heterogeneity of Breast Cancer As an Indicator of the Metastatic Potential and Tumor Chemosensitivity
Authors: Gerashchenko T. S. , Zavyalova M. V. , Denisov E. V. , Krakhmal N. V. , Pautova D. N. , Litviakov N. V. , Vtorushin S. V. , Cherdyntseva N. V. , Perelmuter V. M.
Published: May 2019

Breast cancer (BC) demonstrates considerable intratumoral morphological heterogeneity. The aim of this work was to evaluate the relationship among different morphological structures, the rate of metastasis, and efficacy of neoadjuvant chemotherapy (NAC) in NAC-treated (n = 427) and NAC-nave (n = 249) BC patients. We also studied the involvement of an epithelial-mesenchymal transition (EMT) in the development of the intratumoral morphological heterogeneity of BC. We found a significant association between the intratumoral morphological heterogeneity and the rate of BC metastasis and response to NAC, which, in most cases, correlated with the presence of alveolar and trabecular structures. In particular, the rate of lymph node metastasis in tumors containing alveolar and trabecular structures was higher compared to that in tumors lacking such structures. NAC-treated patients with alveolar and trabecular structures had a high distant metastasis rate and a low metastasis-free survival rate. Furthermore, alveolar and trabecular structures were found to be associated with a lack of response to NAC. Interestingly, the association between alveolar structures and a high distant metastasis rate was found only in NAC-unresponsive patients, whereas the association between trabecular structures and an increased distant metastasis was revealed in responders. Alveolar structures were associated with chemoresistance only in patients with lymph node metastases, whereas trabecular structures were associated with chemoresistance only in patients without lymph node metastases. In general, increased intratumoral morphological diversity correlated with considerable chemoresistance and a high metastasis rate of BC. We found variable expressions of epithelial (EPCAM and CDH1) and mesenchymal (ITGA5, ITGB5, CDH2, CDH11, TGFb2, ZEB1, MMP2, DCN, MST1R) markers and, thus, different EMT manifestations in different morphological structures. Therefore, intratumoral morphological heterogeneity of BC may serve as an indicator of the metastatic potential and tumor chemosensitivity.
Differentiation of Human Pluripotent Stem Cells into Mesodermal and Ectodermal Derivatives Is Independent of the Type of Isogenic Reprogrammed Somatic Cells
Authors: Philonenko E. S. , Shutova M. V. , Khomyakova Е. А. , Vassina Е. М. , Lebedeva О. S. , Kiselev S. L. , Lagarkova М. А.
Published: May 2019

Induced pluripotent stem cells (iPSCs) have the capacity to unlimitedly proliferate and differentiate into all types of somatic cells. This capacity makes them a valuable source of cells for research and clinical use. However, the type of cells to be reprogrammed, the selection of clones, and the various genetic manipulations during reprogramming may have an impact both on the properties of iPSCs and their differentiated derivatives. To assess this influence, we used isogenic lines of iPSCs obtained by reprogramming of three types of somatic cells differentiated from human embryonic stem cells. We showed that technical manipulations in vitro, such as cell sorting and selection of clones, did not lead to the bottleneck effect, and that isogenic iPSCs derived from different types of somatic cells did not differ in their ability to differentiate into the hematopoietic and neural directions. Thus, the type of somatic cells used for the generation of fully reprogrammed iPSCs is not important for the practical and scientific application of iPSCs.
Dual Active Site in the Endolytic Transglycosylase gp144 of Bacteriophage phiKZ
Authors: Chertkov O. V. , Armeev G. A. , Uporov I. V. , Legotsky S. A. , Sykilinda N. N. , Shaytan A. K. , Klyachko N. L. , Miroshnikov K. A.
Published: May 2019

Lytic transglycosylases are abundant peptidoglycan lysing enzymes that degrade the heteropolymers of bacterial cell walls in metabolic processes or in the course of a bacteriophage infection. The conventional catalytic mechanism of transglycosylases involves only the Glu or Asp residue. Endolysin gp144 of Pseudomonas aeruginosa bacteriophage phiKZ belongs to the family of Gram-negative transglycosylases with a modular composition and C-terminal location of the catalytic domain. Glu115 of gp144 performs the predicted role of a catalytic residue. However, replacement of this residue does not completely eliminate the activity of the mutant protein. Site-directed mutagenesis has revealed the participation of Tyr197 in the catalytic mechanism, as well as the presence of a second active site involving Glu178 and Tyr147. The existence of the dual active site was supported by computer modeling and monitoring of the molecular dynamics of the changes in the conformation and surface charge distribution as a consequence of point mutations.
Search for Modified DNA Sites with the Human Methyl-CpG-Binding Enzyme MBD4
Authors: Yakovlev D. A. , Kuznetsova A. A. , Fedorova O. S. , Kuznetsov N. A.
Published: May 2019

The MBD4 enzyme initiates the process of DNA demethylation by the excision of modified DNA bases, resulting in the formation of apurinic/apyrimidinic sites. MBD4 contains a methyl-CpG-binding domain which provides the localization of the enzyme at the CpG sites, and a DNA glycosylase domain that is responsible for the catalytic activity. The aim of this work was to clarify the mechanisms of specific site recognition and formation of catalytically active complexes between model DNA substrates and the catalytic N-glycosylase domain MBD4cat. The conformational changes in MBD4cat and DNA substrates during their interaction were recorded in real time by stopped-flow detection of the fluorescence of tryptophan residues in the enzyme and fluorophores in DNA. A kinetic scheme of MBD4cat interaction with DNA was proposed, and the rate constants for the formation and decomposition of transient reaction intermediates were calculated. Using DNA substrates of different lengths, the formation of the catalytically active complex was shown to follow the primary DNA binding step which is responsible for the search and recognition of the modified base. The results reveal that in the primary complex of MBD4cat with DNA containing modified nucleotides, local melting and bending of the DNA strand occur. On the next step, when the catalytically competent conformation of the enzyme-substrate complex is formed, the modified nucleotide is everted from the double DNA helix into the active center and the void in the helix is filled by the enzymes amino acids.
Huntington’s Disease: Calcium Dyshomeostasis and Pathology Models
Authors: Kolobkova Yu. A. , Vigont V. A. , Shalygin A. V. , Kaznacheyeva E. V.
Published: May 2019

Huntingtons disease (HD) is a severe inherited neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and mental impairment. At the molecular level, HD is caused by a mutation in the first exon of the gene encoding the huntingtin protein. The mutation results in an expanded polyglutamine tract at the N-terminus of the huntingtin protein, causing the neurodegenerative pathology. Calcium dyshomeostasis is believed to be one of the main causes of the disease, which underlies the great interest in the problem among experts in molecular physiology. Recent studies have focused on the development of animal and insect HD models, as well as patient-specific induced pluripotent stem cells (HD-iPSCs), to simulate the diseases progression. Despite a sesquicentennial history of HD studies, the issues of diagnosis and manifestation of the disease have remained topical. The present review addresses these issues.
At the Interface of Three Nucleic Acids: The Role of RNA-Binding Proteins and Poly(ADP-ribose) in DNA Repair
Authors: Alemasova E. E. , Lavrik O. I.
Published: May 2019

RNA-binding proteins (RBPs) regulate RNA metabolism, from synthesis to decay. When bound to RNA, RBPs act as guardians of the genome integrity at different levels, from DNA damage prevention to the post-transcriptional regulation of gene expression. Recently, RBPs have been shown to participate in DNA repair. This fact is of special interest as DNA repair pathways do not generally involve RNA. DNA damage in higher organisms triggers the formation of the RNA-like polymer - poly(ADP-ribose) (PAR). Nucleic acid-like properties allow PAR to recruit DNA- and RNA-binding proteins to the site of DNA damage. It is suggested that poly(ADP-ribose) and RBPs not only modulate the activities of DNA repair factors, but that they also play an important role in the formation of transient repairosome complexes in the nucleus. Cytoplasmic biomolecules are subjected to similar sorting during the formation of RNA assemblages by functionally related mRNAs and promiscuous RBPs. The Y-box-binding protein 1 (YB-1) is the major component of cytoplasmic RNA granules. Although YB-1 is a classic RNA-binding protein, it is now regarded as a non-canonical factor of DNA repair.
Structure Modeling of Human TyrosylDNA Phosphodiesterase 1 and Screening for Its Inhibitors
Authors: Gushchina I. V. , Nilov D. K. , Zakharenko A. L. , Lavrik O. I. , Švedas V. K.
Published: May 2019

The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) represents a potential molecular target for anticancer therapy. A human Tdp1 model has been constructed using the methods of quantum and molecular mechanics, taking into account the ionization states of the amino acid residues in the active site and their interactions with the substrate and competitive inhibitors. The oligonucleotide- and phosphotyrosine-binding cavities important for the inhibitor design have been identified in the enzymes active site. The developed molecular model allowed us to uncover new Tdp1 inhibitors whose sulfo group is capable of occupying the position of the 3-phosphate group of the substrate and forming hydrogen bonds with Lys265, Lys495, and other amino acid residues in the phosphotyrosine binding site.
Role of the Inserted α-Helical Domain in E. coli ATP-Dependent Lon Protease Function
Authors: Kudzhaev A. M. , Andrianova A. G. , Dubovtseva E. S. , Serova O. V. , Rotanova T. V.
Published: May 2019

Multidomain ATP-dependent Lon protease of E. coli (Ec-Lon) is one of the key enzymes of the quality control system of the cellular proteome. A recombinant form of Ec-Lon with deletion of the inserted characteristic -helical HI(CC) domain (Lon-dHI(CC)) has been prepared and investigated to understand the role of this domain. A comparative study of the ATPase, proteolytic, and peptidase activities of the intact Lon protease and Lon-dHI(CC) has been carried out. The ability of the enzymes to undergo autolysis and their ability to bind DNA have been studied as well. It has been shown that the HI(CC) domain of Ec-Lon protease is required for the formation of a functionally active enzyme structure and for the implementation of protein-protein interactions.
Bacteriolytic Activity Of Human Interleukin-2, Chicken Egg Lysozyme In The Presence Of Potential Effectors
Authors: Levashov P. A. , Matolygina D. A. , Ovchinnikova E. D. , Atroshenko D. L. , Savin S. S. , Belogurova N. G. , Smirnov S. A. , Tishkov V. I. , Levashov A. V.
Published: May 2019

The bacteriolytic activity of interleukin-2 and chicken egg lysozyme in the presence of various substances has been studied. Glycine and lysine do not affect the activity of interleukin-2 but increase that of lysozyme, showing a bell-shape concentration dependence peaking at 1.5 mM glycine and 18 mM lysine. Arginine and glutamate activate both interleukin-2 and lysozyme with a concentration dependence of the saturation type. Aromatic amino acids have almost no effect on the activity of both interleukin-2 and lysozyme. Aromatic amines, tryptamine, and tyramine activate interleukin-2 but inhibit lysozyme. Peptide antibiotics affect interleukin and lysozyme similarly and exhibit maximum activity in the micromolar range of antibiotics. Taurine has no effect on the activity of interleukin-2 and lysozyme. Mildronate showed no influence on lysozyme, but it activated interleukin-2 with the activity maximum at 3 mM. EDTA activates both interleukin-2 and lysozyme at concentrations above 0.15 mM.
Pengembangan Modul Pedoman Guru dalam Mendesain Instrumen Penilaian Matematika Berbasis Pemecahan Masalah Matematika
Authors: Kurniawan Antok , Rusdi M , Marzal Jefri
Published: May 2019

This study aims to determine the process, specifications, and teacher's perception of developing a teacher guidance module in making mathematical assessment instruments based on mathematical problem-solving. This study uses the Research and Development method which is used to produce certain products, namely teacher guidance modules. The development model used in this study is the development model that Marshall et al. (2009), Tryon and Bishop et al (2012) and Rusdi (2018) combined by researchers into references. The steps consist of the problem and need analysis, literature review, product design, validity, practitioner trials. The research subjects in this development were two validators consisting of material expert validators, instrument design expert test validators, and five practitioners. The type of data taken in this study is qualitative data. The instrument used in the study was an open questionnaire. The process stages in developing are (a) Analysis of problems and needs, (b) literature review, (c) product design, (d) validity, (e) trial practitioners. The product specifications developed in the module are that there are three chapters on introduction, concepts, and procedures accompanied by examples by using types of problem-solving, namely problem-solving design and story problem. Teacher's perception in the teacher guidance module is positive, of the five practitioners recommending that it be used as a guide in making problem-solving problems.
Upaya Meningkatkan Hasil Belajar IPS dengan Menggunakan Model Pembelajaran Course Review Horay
Authors: Ramli Muhamad , Isnawati Isnawati
Published: May 2019

Pembelajaran yang terlaksana hanya satu arah sehingga peserta didik kurang aktif dan hasil belajar menjadi rendah, maka dari itu penelitian ini bertujuan untuk: (1) mendeskripsikan peningkatan aktivitas belajar peserta didik pada saat menggunakan model pembelajaran Course Review Horay, (2) mendeskripsikan peningkatan hasil belajar IPS setelah menggunakan model pembelajaran course review horay. Subjek penelitian ini adalah peserta didik kelas IV SDN 2 Ruwung Buyung Kecamatan Cempaga Hulu. Metode yang digunakan adalah Penelitian Tindakan Kelas (PTK). Hasil penelitian didapatkan bahwa: (1) terjadi peningkatan hasil belajar pada peserta didik kelas IV SDN 2 ruwang buyung kecamatan cempaga hulu setelah menggunakan model pembelajaran coursey review horay, (2) peningkatan hasil belajar peserta didik dapat dilihat dari hasil belajar pada siklus I sebanyak 46,42% peserta didik yang tuntas dan pada siklus II sebanyak 89,28% peserta didik yang tuntas.
Upaya Meningkatkan Kemampuan Menulis Karangan Tema Lingkungan dengan Menggunakan Media Alam Sekitar
Authors: Afrom Ichyatul , Ulpah Maria
Published: May 2019

Penelitian ini bertujuan untuk : (1) mendeskripsikan aktivitas kemampuan menulis karangan peserta didik dengan menggunakan media alam sekitar, dan (2) mendeskripsikan peningkatan kemampuan menulis karangan tema lingkungan dengan menggunakan media alam sekitar. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) dengan subjek penelitiannya yaitu peserta didik kelas V di SD Negeri 5 Menteng Palangka Raya tahun pelajaran 2014/2015. Analisis data menggunakan analisis data kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa: (1) ada peningkatan kemampuan menulis karangan tema lingkungan dengan menggunakan medi alam sekitar, dan (2) peningkatan kemampuan menulis karangan tema lingkungan dengan menggunakan media alam sekitar ditunjukan dengan nilai rata-rata 57,11 sebelum perlakuan, kemudian siklus I ketuntasannya meningkat menjadi 65,38% dengan nilai rata-rata73,42 dan siklus II seluruh peserta didik kelas V SDN -5 Menteng tuntas dengan pencapaian ketuntasan klasikal 100% dan rata-rata nilai 82,5.
Penggunaan Media Gambar Pecahan dalam Meningkatkan Hasil Belajar Matematika
Authors: Orhan Orhan , Norhayati Micke
Published: May 2019

Penelitian ini bertujuan untuk (1) mendeskripsikan aktivitas belajar matematika dengan penggunaan media gambar, dan (2) mendeskripsikan peningkatan hasil belajar matematika dengan menggunakan media gambar. Metode penelitian yang digunakan adalah Penelitian Tindakan Kelas (PTK). Subjek penelitiannya adalah peserta didik kelas IV SD Negeri 1 Tanjung Jaringau tahun Ajaran 2014-2015. Teknik analisis data yang digunakan ada dua macam yaitu kuantitatif dan kualitatif. Hasil penelitian menunjukkan bahwa: (1) ada peningkatan aktivitas belajar Matematika dengan menggunakan media gambar. (2) ada peningkatan hasil belajar Matematika dengan menggunakan media gambar, peningkatan hasil belajar dapat dilihat dari nilai rata-rata data awal yaitu 40 dengan ketuntasan belajar secara klasikal yaitu 19%. Siklus I hasil belajar yang diperoleh yaitu 55 dengan ketuntasan klasikal 69%. Siklus II hasil belajar yang diperoleh yaitu 68 dengan ketuntasan klasikal 94%.
Upaya Meningkatkan Hasil Belajar Matematika melalui Penggunaan Media Manipulatif
Authors: Rahmaniati Rita , Hijriah Nurul
Published: May 2019

Tujuan yang ingin dicapai dalam penelitian ini adalah (1) untuk mendeskripsikan aktivitas belajar peserta didik dalam pembelajaran matematika dengan menggunakan media manipulatif, (2) untuk mendeskripsikan peningkatan hasil belajar matematika dengan menggunakan media manipulatif. Jenis penelitian ini adalah penelitian tindakan kelas (PTK). Subjek dalam penelitian ini adalah peserta didik kelas IV SDN 2 Kereng Bangkirai. Teknik pengumpulan data dalam penelitian ini yaitu tes, observasi, dan teknik analisis data dalam penelitian ini adalah kuantitatif-kualitatif. Hasil penelitian menunjukan bahwa (1) ada peningkatan aktivitas belajar peserta didik, dan (2) ada peningkatan hasil belajar matematika dengan menggunakan media manipulatif pada peserta didik kelas IV SDN 2 Kereng Bangkirai Tahun Pelajaran 2014/2015 dengan nilai ketuntasan klasikal yaitu 100%.
Upaya Meningkatkan Hasil Belajar IPA dengan Menerapkan Model Pembelajaran Guided Discovery
Authors: Diplan Diplan , Mulia Sari
Published: May 2019

Penelitian ini bertujuan untuk : (1) mendeskripsikan aktivitas belajar IPA peserta didik dengan menerapkan model pembelajaran Guided Discovery, dan (2) mendeskripsikan peningkatan hasil belajar IPA peserta didik setelah menerapkan model pembelajaran Guided Discovery. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) dengan subjek penelitiannya yaitu peserta didik kelas V SDN 7 Selat Hulu Kuala Kapuas. Analisis data menggunakan analisis data kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa: (1) model pembelajaran Guided Discovery dapat meningkatkan aktivitas belajar IPA peserta didik, dan (2) peningkatan hasil belajar IPA dengan model pembelajaran Guided Discovery ditunjukkan dengan perolehan nilai rata-rata 67,70 pada siklus I meningkat menjadi 87,08 pada siklus II. Ketuntasan belajar secara klasikal juga mengalami peningkatan dengan nilai 79,2% pada siklus I meningkat menjadi 100% pada siklus II
Peningkatan Hasil Belajar Matematika Menggunakan Model Pembelajaran Berbasis Masalah pada Peserta Didik
Authors: Najihi Aidin , Novianti Eka
Published: May 2019

Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar peserta didik dalam pembelajaran matematika dengan menggunakan model pembelajaran berbasis masalah.Metode penelitian yang digunakan dalam penelitian ini adalah metode Penelitian Tindakan Kelas (PTK). Penelitian ini menggunakan lembar observasi dan angket. Observasi dilakukan untuk mengamati aktivitas guru, peserta didik, dan pengelolaan pembelajaran..Hasil penelitian menunjukkan bahwa ada peningkatan hasil belajar peserta didik pada saat proses pembelajaran matematika dengan menggunakan model pembelajaran berbaisis masalah pada peserta didik. Hal ini ditunjukan dari data pratindakan sebelum menggunakan model pembelajaran berbasis masalah dimana ketuntasan belajar pra test sebesar 26%, kemudian pada post test I sebesar 52% masih belum mencapai 60%. Maka di lanjutkan pada siklus II dan hasilnya semua peserta didik telah mampu mencapai KKM 6.00, serta ketuntasan belajar post test II sebesar 100%. Berdasarkan data tersebut maka setelah dilakukan pembelajaran matematika menggunakan model pembelajaran berbasis masalah terjadi peningkatan hasil belajar peserta didik sebesar 74% dari nilai awal ketuntasan belajar pra test sebesar 26%.
Penggunaan Media Objek untuk Meningkatkan Hasil Belajar IPA Peserta Didik
Authors: Miftahurrizqi Miftahurrizqi , Masroah Masroah
Published: May 2019

Penelitian ini bertujuan untuk mengetahui keberhasilan penggunaan media objek dilihat dari hasil belajar peserta didik kelas V SDN-6 Langkai Palangkaraya Tahun Pelajaran 2012/2013 dan melihat apakah ada peningkatan hasil belajar peserta didik dengan menggunakan media objek yang sebelumnya masih dibawah nilai ketuntasan minimal belajar (KKM). Metode penelitian yang digunakan dalam penelitian ini adalah penelitian tindakan kelas (PTK). Populasi penelitian berjumlah 22 orang peserta didik yang sekaligus dijadikan sampel penelitian. Teknik analisis data yang digunakan untuk menghitung keberhasilan belajar peserta didik menggunakan rumus persentase yaitu 100% dimana melihat peningkatan dari siklus I dan siklus II. Hasil penelitian menunjukan bahwa : penggunaan media objek sangat efektif untuk meningkatkan hasil belajar IPA peserta didik kelas V SDN-6 Langkai Palangkaraya Tahun Pelajaran 2012/2013. Hasil ini dapat dibuktikan dengan perolehan nilai rata-rata setiap siklus semakin meningkat. Pada siklus I nilai rata-rata yang diperoleh adalah 77,27% dengan kategori baik tapi masih ada peserta didik yang belum tuntas dan akan dilanjutkan pada siklus II hasil belajar IPA peserta didik terlihat sangat meningkat dengan perolehan nilai rata-rata 86,81% pada kategori sangat baik.
Perbedaan Hasil Belajar Matematika Menggunakan Media Gambar dengan Media Konkret pada Pelajaran Geometri
Authors: Wulandari Annisa , Rahmawati Fery
Published: May 2019

Penelitian ini bertujuan untuk mengetahui ada tidaknya perbedaan hasil belajar matematika yang pada pembelajarannya menggunakan media konkret dengan media gambar pada peserta didik kelas VI SDN 5 Pahandut Palangka Raya Tahun pelajaran 2012/2013. Metode dalam penelitian ini menggunakan metode Eksperimen dan teknik pengumpulan data dengan menggunakan instrument berupa tes. Populasi penelitian ini adalah seluruh peserta didik kelas VI SDN 5 Pahandut Palangkaraya, yang berjumlah 40 orang peserta didik. Penelitian ini merupakan penelitian populasi. Teknik analisis data yang digunakan adalah uji t. Berdasarkan uji hipotesis diperoleh thit sebesar 2,17 sedangkan ttab pada taraf signifikansi 5% sebesar 1,690. Dengan demikian thit lebih dari dibandingkan ttab yaitu 2,17 > 1,690, maka Ho ditolak. Jadi terdapat perbedaan hasil belajar matematika antara yang menggunakan media gambar dan media konkret peserta didik kelas VI SDN 5 Pahandut Palangkaraya.
Penggunaan Media Tiga Dimensi dalam Meningkatkan Hasil Belajar Matematika Peserta Didik
Authors: Setyawan Dedy , Fitriadi Muhammad
Published: May 2019

Penelitian ini bertujuan untuk mengetahui bagaimana peningkatan hasil belajar matematika kelas IV/B SDN-3 Kereng Bangkirai setelah menggunakan media tiga dimensi. Metode yang digunakan peneliti adalah menggunakan rancangan Penelitian Tindakan Kelas (PTK). Populasi penelitian berjumlah 26 peserta didik yang sekaligus dijadikan sebagai sampel penelitian. Teknik analisis data didasarkan pada hasil siklus saat proses pembelajaran. Hasil penelitian menunjukkan bahwa : Penggunaan media tiga dimensi dapat meningkatkan hasil belajar Matematika peserta didik kelas IV/B SDN-3 Kereng Bangkirai tahun pelajaran 2012/2013. Hal ini dapat dibuktikan dengan perolehan nilai rata-rata setiap siklus semakin meningkat. Pada siklus I nilai rata-rata yang diperoleh yaitu 66,06 dengan kriteria tingkat keberhasilan pembelajaran tercapai. Sedangkan pada siklus II nilai rata-rata yang diperoleh 92,31 dengan kriteria tingkat keberhasilan pembelajaran sangat tercapai.
Pemanfaatan Teknologi Gadget Sebagai Media Pembelajaran
Authors: Putra Chandra Anugrah
Published: May 2019

Tuntutan dan kebutuhan masyarakat yang semakin meningkat seperti sandang, pangan, dan papan terus melambung tinggi sama seperti melambungnya kemajuan teknologi dan informasi saat ini. Yang dimana keterkaitan dan interaksi manusia dengan teknologi sudah dijadikan hal nya seperti kebutuhan pokok dan kebutuhan setiap saat, salah satu contoh keterikatan manusia dengan teknologi yang saat ini terus berkembang dan menjadi dunia persaingan sendiri untuk perusahaan dan developer teknologi, salah satu nya adalah teknologi gadget. Gadget merupakan perangkat elektronik kecil yang memiliki fungsi khusus di setiap jenis nya untuk memudahkan pekerjaan dan kebutuhan manusia menjadi lebih praktis dan efisien. Tidak seperti hal nya manusia yang mempunyai teknologi canggih hanya dimiliki kaum strata atas, lain dengan teknologi mini elektronik yang sekarang hampir dimiliki kaum mayoritas menengah maupun bawah yaitu teknologi gadget.
Perbedaan Hasil Belajar IPA dilihat dari Penggunaan Media Konkret dengan Media Audio-Visual pada Peserta Didik Kelas IV SDN-1 Panarung Palangkaraya
Authors: Desy Desy , Diplan Diplan
Published: May 2019

This study aims to determine whether or not there are differences in learning outcomes of science seen from the use of concrete media with audio-visual media in fourth-grade students of SDN 1 Panarung 2015/2016 Academic Year. The research method in this study is a quantitative correlation. The results of the study show that there are differences in learning outcomes of science seen from the use of concrete media with audio-visual media in fourth-grade students of SDN 1 Panarung 2015/2016 Academic Year. with a count of t count of 6.012 and t table of 2,000 at N = 59 with a significant level of 5% for 2 tails which means tcount> t table or 6.012> 2,000.
Upaya Meningkatkan Hasil Belajar Peserta Didik dengan Menggunakan Media Audio Visual pada Pelajaran Bahasa Indonesia Kelas V SDN-5 Menteng Palangka Raya
Authors: Gunawan Hendri , Khunaifi A'am Rifaldi
Published: May 2019

This study aims to determine whether or not there is an increase in activity and learning outcomes of students in Indonesian language lessons, the subject of listening to population density using audio grade V media in Menteng-5 Elementary School Palangkaraya. The research method used in this study is the Classroom Action Research (CAR) method. With the number of research subjects 28 students. There was an increase in the activity of students when the learning process of Indonesian Language especially listening to news using Audio Visual media in class V students of SDN-5 Menteng Palangkaraya this was evidenced by the results of the average activity of students namely 3.65 while the average activity teacher is 3.64. There has been an increase in learning outcomes after being distributed using audiovisual media listening to the news on Indonesian language lessons for students in the fifth-grade of Menteng-5 SDN Palangkaraya. This can be seen from the learning outcomes of students, in the first cycle that is 73.03 and the classical completeness is 60.71% and in the second cycle it increases to 81.25 and the classical completeness is 100%.
Upaya Meningkatkan Hasil Belajar IPA menggunakan Model Pembelajaran Direct Instruction (DI) Berbantuan Media Audio Visual pada Peserta Didik
Authors: Cancie Cancie , Permadi Ade Salahuddin
Published: May 2019

This research aims to improve the learning outcomes of science and describe the learning activities of students by using Direct Instruction learning models assisted by Audio Visual media on students. The research method used in this study was classroom action research (PTK). The research subjects were 27-grade SDN 3 Panarung students. The technique of collecting data uses observation and tests. The results of the study show that the learning activities of students become good. Teacher activities in the first cycle averaged 2.4 categories quite well and the second cycle averaged 3.5 good categories, while the activities of students in the first cycle averaged 2.6 categories enough and the second cycle averaged 3.1 categories well. There is an increase in science learning outcomes using the Direct Instruction (DI) learning model assisted by Audio Visual media in fourth grade students of SDN-3 Panarung Palangka Raya 2016/2017 school year with the results of analysis on the Pratindakan classical completeness which is 40.7% with an average value 65, the first cycle of classical completeness is 74% with an average value of 72, and classical completeness in cycle II is 100% with an average value of 87.5
Upaya Meningkatkan Hasil Belajar IPA menggunakan Model Picture and Picture dengan Media Animasi di SDS Muhammadiyah Selat Tahun Pelajaran 2016/2017
Authors: Budiono Muhamad Faisal , Najihi Aidin
Published: May 2019

This study aims to improve learning outcomes and describe the learning activities of Va SDS Muhammadiyah Selat students using Animation media. The subjects in this study consisted of 27 students, 14 men, and 13 women. Data collection techniques used were observation and tests. Data analysis uses qualitative and quantitative data analysis. The results of this study indicate that the use of animation media can improve the learning outcomes of science students in VA class SDS Muhammadiyah Straits of Kuala Kapuas. This is based on the results of research with the acquisition of values in the learning activities that have been carried out for two cycles, it can be concluded that: The use of poster media can improve student learning outcomes, this can be seen from the pre-action average = 40.55 with classical completeness 7.40 %, the average cycle I = 45 with classical completeness 22.27% and cycle II = 72 with classical completeness 88.88%.