bluuebunny/crossref_metadata_2025 huggingface dataset:
De las seriedades de Urania a las zumbas de Talía. Astrología frente a entretenimiento en la censura de los almanaques de la primera mitad del XVIII, Oviedo, IFESXVIII / Ediciones Trea (ACESXVIII, 6), 2021
Authors: Durán López Fernando
Published: December 2022

En la España de la primera mitad del siglo XVIII se experimenta un auge de los almanaques, o pronósticos astrológicos anuales. Este género de impresos sufre profundos cambios que lo hacen evolucionar desde el campo de la ciencia astrológica hacia el de la literatura de entretenimiento o la literatura didáctica. La hipótesis formulada es que tales cambios son una reacción ante el desprestigio de la astrología, en particular la judiciaria, que obliga a reconfigurar la legitimación social e intelectual de los almanaques, reclasificándolos bajo criterios de utilidad y de calidad literaria, en vez de eficacia científica. Este estudio cartografía la clasificación intelectual de los almanaques mediante el análisis de trescientas censuras incluidas como «aprobaciones» en los propios impresos, y pretende igualmente ofrecer un modelo para el uso de estos documentos en los estudios literarios de este periodo.
El arte del reloj en las manos del lector. Impresos de relojería mecánica en el mundo hispánico del siglo XVIII, Oviedo, IFESXVIII / Ediciones Trea (ACESXVIII, 7), 2021
Authors: Uribe Ricardo
Published: December 2022

La consulta del reloj no es una práctica simple ni espontánea, y mucho menos una manía adquirida únicamente por la «disciplina de trabajo y el capitalismo industrial». Esto es lo que nos viene a iluminar el estudio de una serie de impresos que se produjeron y circularon en España y América. Tratados, manuales, artículos de prensa y papeles sueltos que hasta cierto punto revelaron los secretos del relojero, al tiempo que recogieron, acreditaron o refutaron las nociones populares que circulaban en torno al reloj. Con este material se pone en suspenso las hipótesis adoptadas de la historiografía anglosajona, para abrirle espacio a una visión que permite entender cómo diferentes individuos ubicados en ambas partes del mundo, ajenos al régimen fabril y sin otro nexo en común que la posesión de relojes, se vincularon al campo de la cronometría, convinieron en las mismas técnicas y en conjunto configuraron un tiempo sintético a escala global.
Los archivos rioplatenses y su organización: imagen y realidad, Oviedo, IFESXVIII / Ediciones Trea (ACESXVIII, 8), 2021
Authors: Díaz de Zappia Sandra L.
Published: December 2022

Este trabajo estudia la imagen de los archivos rioplatenses entre comienzos del siglo XVII y 1821, cuando se crea el Archivo de la Provincia de Buenos Aires. Para ello se presenta, en primer lugar, un análisis de la imagen del archivo en tanto continente. En segundo, se trata la imagen del archivo en razón de su contenido. Seguidamente, se profundiza sobre su organización considerando la naturaleza del empleo de archivero, la presencia de ayudantes y las tareas que aquél tenía a su cargo. Finalmente, se reseñan los casos en que se aprecia algún tipo de deterioro de los documentos y las iniciativas destinadas a recomponerlos. Complementariamente, se incluye un apéndice con veintiséis textos que representan tanto el marco jurídico regulatorio local existente en el período estudiado como también diversos informes relativos a la organización de los archivos de la región.
La producción del dramaturgo valenciano José Vallés, Oviedo, IFESXVIII / Ediciones Trea (ACESXVIII, 9), 2022.
Authors: Sarrió Rubio Pilar
Published: December 2022

En estas páginas se muestra la vocación teatral de José Vallés, reflejada en las actividades que realizó en el mundo del teatro: actor, músico violinista, apuntador y dramaturgo o poeta. Y también, su vida azarosa, como la de otros miembros del mundo teatral; sus traslados de una ciudad a otra para representar en sus teatros los espectáculos que agradaban al público; y sobre todo, tener que vivir día tras día en lamentables condiciones sin menoscabo de su gran profesionalidad dramática.
A rare case of systemic AL-amyloidosis under the mask of myocardial infarction in the absence of myocardial hypertrophy: case report
Authors: Boldueva Svetlana A. , Evdokimov Dmitriy S. , Rozhdestvenskaya Marina V. , Vinnichuk Sergey A. , Mitrofanova Lyubov B.
Published: December 2022

Systemic amyloidosis is a group of diseases associated with extracellular deposition of fibrillar proteins, resulting in the loss of normal organ structure and function. AL-amyloidosis occurs when amyloid is deposited, consisting of full-length lambda or kappa immunoglobulin light chains, or fragments thereof. This article describes the complexity of timely diagnosis of systemic AL-amyloidosis with a predominant heart lesion in the absence of myocardial hypertrophy on the example of an elderly patient in whom the leading manifestation of the disease was heart failure with a preserved left ventricular ejection fraction.
The role of rs3025058 polymorphism in the development of ischemic stroke in patients with cardiovascular diseases (review)
Authors: Nikulin Dmitry A. , Chernova Anna A. , Nikulina Svetlana J. , Maksimov Vladimir N.
Published: December 2022

Acute cerebrovascular accident (ACC) is a formidable complication of a number of cardiovascular diseases, in a significant percentage of cases leading to disability and mortality. The literature available to us provides information on the role of type 3 matrix metalloproteinase gene (MMP-3) polymorphism in the development of stroke. It is believed that MMP-3 plays an important role in the natural processes of tissue remodeling and pathological processes. The mechanism of regulation of tissue remodeling MMP-3 is based on the activation of procollagenase-1. The associations of the single-nucleotide variant rs3025058 (5A/6A) with the development of ONMK in patients with cardiovascular pathology and risk factors of its development for the implementation of measures of primary prevention of this disease are considered. The article discusses issues related to the role and identification of associations of the single nucleotide variant rs3025058 (5А/6А) with the development of stroke in patients with cardiovascular pathology. When preparing the review, publications were searched in the MEDLINE/PubMed, Scopus, Cochrane Library, PEDro, eLIBRARY databases and Google Scholar. In preparing the literature review, the analysis of publications for the last 15 years is carried out. Represented evidence suggests the need for further study and effective use of the results of the study of the rs3025058 MMP-3 polymorphism for the implementation of primary prevention measures in the development of acute cerebrovascular accident, especially in the families of these patients.
Identification of SNPs and InDels probably associated with the development of spontaneous tumors in radish (Raphanus sativus L.)
Authors: Kuznetsova Ksenia  A. , Dodueva Irina E. , Lutova Lyudmila A.
Published: December 2022

Radish (Raphanus sativus L.) is an agronomically important root crop belonging to the Brassicaceae family. A genetic collection of inbred radish lines, which was based on contrasting genetically determined traits including trait ability to develop tumors, was created at St. Petersburg State University in the middle of the 20th century [1]. Full genetics network controlling this trait still remains unclear [2], and elucidation of its mechanisms can help reveal the key regulators of systemic mechanisms that control cell proliferation and differentiation.

The purpose of this work is to identify single nucleotide polymorphisms (SNPs) and InDels in genes which are candidates for participation in the tumor development process within in the tumor-forming radish line compared to the non-tumor radish line.

We have assembled the genomes of two lines contrasting in the ability to tumorigenesis, annotated them, aligned sequences per assembly, identified candidate genes and differences in the structure of these genes in contrasting radish lines using bioinformatics tools. Bioinformatics data were confirmed by the sequencing by Sanger method.

As a result, in the tumor-forming radish line we identified 151 genes with InDels in their coding regions, which led to various variants of frameshift. Moreover, we detected 39 genes with single nucleotide substitutions (SNPs). According to the gene pathway enrichment analysis, the corresponding genes were classified into the several groups.

Thus, the data obtained will allow us to clarify in more detail the genetic control mechanisms of the tumor development in radish.

The work was supported by the Ministry of Science and Higher Education of the Russian Federation in accordance with the agreement No. 075-15-2022-322.
The MtWOX and MtCLE genes in the regulation of Medicago truncatula somatic embryogenesis
Authors: Efremova Elena  P. , Tvorogova Varvara  E. , Lutova Ludmila  A.
Published: December 2022

Plant somatic cells can be reprogrammed into totipotent embryonic cells that are able to form differentiated embryos in a process called somatic embryogenesis (SE). SE can occur naturally in various plant species and it is widely used for clonal propagation, transformation and regeneration of different crops. This process is regulated by hormone treatment and many proteins, among which WUSCHEL-related homeobox (WOX) transcription factors are believed to play crucial roles. The WOX family is involved in the regulation of a wide range of key developmental programs in different plant organs and tissues. CLE peptides are well-known hormonal regulators of plant development. WOX and CLE genes can be related to each other through feedback regulatory loops.

Our previous studies have shown that MtWOX9-1 stimulates SE in Medicago truncatula [1] and overexpression of the MtWOX9-1 gene increases the expression level of the MtCLE08, MtCLE16, MtCLE18 genes in SE. In this study, we examine the overexpression effect of MtCLE08, 16, and 18 on the expression level of MtWOX9-1 gene and a number of other MtWOX genes, which were shown to change expression in SE according to the transcriptomic data. No significant impact of MtCLE overexpression on any MtWOX gene under study was found.

Our findings could be a helpful point for searching and studying new morphogenetic regulators controlling SE and could have a positive impact on plant biotechnology in improving the transformation and regeneration capacity for other legumes.

The research was supported by grant from the Russian Foundation for Basic Research No. 20-016-00124.
Heterologous expression of β-alanine betaine biosynthesis gene increases Nicotiana tabacum resistance to abiotic stresses
Authors: Degtyarenko Anton I. , Stepochkina Varvara D. , Shkryl Yury N.
Published: December 2022

Plant genetic modification in order to increase their tolerance to various abiotic stresses has been of exceptional importance in recent years. Heterologous expression of glycine betaine (GB) biosynthetic genes leads to increased salt and drought tolerance in various plant species by maintaining the osmotic balance with the environment and stabilizing the quaternary structure of complex proteins. However, GB biosynthesis in transgenic plants is limited by choline availability. Members of the Plumbaginaceae family accumulate -alanine betaine (AB) instead [1]. The synthesis of AB is not limited by the availability of choline, as it follows the methylation pathway of the aproteinogenic amino acid -alanine.
For the first time, we have generated Nicotiana tabacum plants expressing the -alanine N-methyltransferase (LlBANMT) gene of Limonium latifolium. Transgenic plants were much less affected by such abiotic stresses as increased salinity, excessive illumination, and low temperature. The experimental Nicotiana tabacum lines had lower rates of chlorophyll degradation under stress conditions compared to the control plants. LlBANMT expression also resulted in less biomass loss under stress conditions, which was associated with higher activities of reactive oxygen species detoxification systems and healthier cell membranes. The presented data demonstrate for the first time the protective properties of LlBANMT heterologous expression and shed light on the mechanisms of its action.
Prospects for the use of natural transgenic cultivated peanut (Arachis hypogaea L.) in breeding
Authors: Bemova Viktoriya D. , Matveeva Tatiana M.
Published: December 2022

Common peanut (Arachis hypogaea L.), or peanut, is an annual herbaceous plant from the legume family (Fabaceae). Russia is one of the largest buyers of peanuts, and at the same time, in the south of the country, a number of zones meet the requirements for the cultivation of this crop. However, at present there are no commercial peanut crops in Russia, and selection work is almost not carried out. It is necessary to identify a new source material for breeding and breeding new high-yielding varieties. In the genomes of species of the genus Arachis, homologues of agrobacterial opine synthase genes, cucumopine synthase (cus) and deoxyfructosylglutamine synthase (mas2`), have been identified. The expression of these genes can affect the economically valuable traits of the plant, since the synthesis of various opines affects the composition of the microbiome in the rhizosphere. We have analyzed the expression of the cus gene in various organs of 9 peanut lines from the VIR collection, which have different geographical origin, belong to different cultivar types, and differ in morphological characters. As a result of the analysis, the organ-specific expression was shown; samples were identified that were contrasting in terms of the level of cus gene expression, including those with a high level of expression in the roots (kk-168, 416, 751). For the first time, data were obtained on the work of the cus gene at different stages of plant development on accessions k-168 and k-1157. An increase in the level of expression in the roots during flowering was revealed; during seed germination, the expression is lower. Further analysis and search for a correlation between the expression level of the cus gene and the manifestation of economically valuable traits in peanuts can provide new material for creating promising varieties.
The studies were carried out using the equipment of the resource center of the Science Park of Saint Petersburg State University Development of molecular and cellular technologies.
This work was supported by the Russian Science Foundation grant No. 21-14-00050.
Komagataella phaffii yeast as a model organism in biotechnology and fundamental research
Authors: Rumyantsev Andrey M. , Sidorin Anton V. , Ianshina Tatiana M. , Petrova Kristina D. , Ishtuganova Valeriia V. , Sambuk Elena V. , Padkina Marina V.
Published: December 2022

The choice of a model organism in biology is based on various factors, such as practical significance and ease of manipulation. Saccharomyces cerevisiae yeast is one of the most widely used and well-studied eukaryotic models. However, developments in NGS, proteomics, metabolomics and gene editing methods allow other species to become the object of fundamental research. A good example of such emerging model organisms is the yeast Komagataella phaffii.

K. phaffii belongs to a unique group of eukaryotic methylotrophs that can use methanol as the sole source of carbon and energy. On the other hand, K. phaffii seems to be more characteristic of the common ancient yeast ancestors than the rapidly evolving S. cerevisiae. Comparative studies between S. cerevisiae and K. phaffii will shed light on the mechanisms of evolution of metabolic pathways and regulatory systems. Such studies are accelerated by the practical importance of K. phaffii as a common microbial production host in biotechnology.

In our studies, we demonstrate that some amino acids greatly affect gene expression in K. phaffii [1]. Transcriptome analysis revealed drastic changes in gene expression when proline was present in the media. About 18.9% of total protein-coding genes were differentially expressed, including genes involved in methanol utilization [2]. Our results show that the unique methanol metabolism pathway is regulated not only by methanol, but also by other carbon sources. Therefore, our findings suggest that the regulation of methanol metabolism pathway is integrated into other cellular regulatory networks. Methanol metabolism, acquired by K. phaffii during evolution, is tightly associated with nitrogen an amino acid metabolism.
Development of a transgenic tissue visualization system in representatives of Fabaceae
Authors: Kozlov Nikolai V. , Simonova Veronika Y. , Krasnoperova Elizaveta Y. , Potsenkovskaia Elina A. , Tvorogova Varvara E. , Lutova Ludmila A.
Published: December 2022

Plant organisms are the objects of green biotechnology, which have been used by humans in various areas of life. The family of legumes (Fabaceae) that is being studied in this work is not an exception here. It is a very diverse family widespread throughout the globe.

Barrel medic (Medicago truncatula) and common pea (Pisum sativum), members of the legume family, were selected in this study for the development of an vital imaging system for transgenic tissues. As a part of the work, we tested an imaging system with post-mortem staining based on the GUS reporter, as well as a system for vital detection of transgenic tissue with fluorescent proteins GFP and DsRed. At this stage, vital imaging systems based on betalain and anthocyanin staining of transgenic tissues are designed and currently being adapted to the model objects under study.

The results of this study may be useful for subsequent attempts to solve the problem of the low efficiency of transformation of P. sativum. Moreover, such a system should be useful in the study of gene regulatory networks and factors that regulate the process of induction and subsequent development of somatic embryos. In addition, it can be used to track the dynamics of expression of genes of interest on living objects, while studying other fundamental and biotechnological processes.

The study is supported by the Russian Foundation for Basic Research (20-016-00124).
Evolution and epidemiology of global populations of nursery-associated Agrobacterium
Authors: Weisberg Alexandra , Davis II Edward , Tabima Javier , Putnam Melodie , Miller Marilyn , Belcher Michael , Grünwald Niklaus , Ream Walt , Lai Erh-Min , Kuo Chih-Horng , Loper Joyce , Chang Jeff
Published: December 2022

Agrobacterium tumefaciens is unique in that it can facilitate the interkingdom transfer of DNA and genetically modify its plant host. While Agrobacterium has been coopted for use in the genetic modification of plants, it is also a major pathogen, causing crown gall disease in the nursery, orchard, and vineyard industries. Pathogenicity in Agrobacterium is the result of two components. First is the Ti plasmid, which carries virulence genes and the transferred T-DNA region. The second component is the chromosome of Agrobacterium, which comprises diverse bacterial lineages and multiple species-level groups. The Ti plasmid can be transferred from strain to strain, diversifying the pathogen and complicating efforts to understand its epidemiology. This system provides an opportunity to study transmission of plasmids and their impact on disease persistence and spread. However, the movement of plasmids, and diversity of chromosomal lineages, means that conventional methods of using whole genome SNPs to track outbreaks are not sufficient, and new techniques must be developed. Additionally, Ti plasmids, like Agrobacterium, are genetically diverse and represent multiple plasmid types. Using a framework of 200 sequenced Agrobacterium genomes isolated from around the world, and a previously developed model of Ti plasmid types, we modelled their epidemiology. Key to this study was that we first separately analyzed plasmids and strain. Combining results revealed links between nurseries, potential horizontal transfer of the plasmid between strains within nurseries, global spread of plasmids, and long-term persistence of plasmids in the agricultural system. Agricultural practices have the potential to promote the diversification of pathogens and the emergence of new pathogen lineages.
Legal aspects of new genetic technologies
Authors: Bruskin Sergey A.
Published: December 2022

The development of genomic editing technologies has significantly intesificated the shortcomings of the legal regulation for genetic technologies as in general and as for new technologies of genetic engineering in particular. Because of imperfected legislation for genetic engineering, and in some cases because of its archaism, new genomic technologies, such as genetic editing technologies, which are growth drivers in science, could not be drivers in the economics. The outdated terms and concepts framework and the legal indetermination of using the products based on new genetic technologies (including genome editing) are barriers to achieving the goals to ensure the technological independence of Russia.

The basis of the current legal regulation system of genetic engineering in Russia is a focus to the process and technologies, i.e. methods of the product producing. This means that the changes within genetic information is not important, but only the method of development is. Such way of regulation provides a priori chronic lag in legislation, which could finally lead to technological lag as whole country. The transition to a product-oriented system, when the analysis of base of genetic information changes makes possible to clearly answer to the question of the methods used for this, will allow us to avoid the shortcomings within development of synthetic biology methods indicated earlier, as now as in the future.
Investigating Injection Pressure as a Predictor to Enhance Real-Time Forecasting of Fluid-Induced Seismicity: A Bayesian Model Comparison
Authors: Feng Yu , Mignan Arnaud , Sornette Didier , Gao Ke
Published: December 2022

Fluid-induced seismicity is now a growing concern in the spotlight and managing its risks entails a probabilistic forecast model suited to real-time applications, which commonly relies on the operational parameter of injection rate in a nonhomogeneous Poisson process. However, due to potential injectivity change, gas kicks, and other processes, injection rate may not provide as robust a proxy for the forcing process as injection pressure, which embodies fluid–rock interactions. Hence, we present a Bayesian approach to prospective model comparison with parameter uncertainties considered. We tested nine geothermal stimulation case studies to comprehensively demonstrate that injection pressure is indeed the main physical predictor of induced seismicity relative to injection rate, and when combined with the latter as predictors, can give the best-performing model and robustly enhance real-time probabilistic forecasting of induced seismicity. We also discussed the implications of our results for seismic risk management and potential directions for further model improvement.
2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma
Authors:   Korean Liver Cancer Association (KLCA) and National Cancer Center (NCC) Korea
Published: December 2022

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the fourth most common cancer among men in South Korea, where the prevalence of chronic hepatitis B infection is high in middle and old age. The current practice guidelines will provide useful and sensible advice for the clinical management of patients with HCC. A total of 49 experts in the fields of hepatology, oncology, surgery, radiology, and radiation oncology from the Korean Liver Cancer Association-National Cancer Center Korea Practice Guideline Revision Committee revised the 2018 Korean guidelines and developed new recommendations that integrate the most up-to-date research findings and expert opinions. These guidelines provide useful information and direction for all clinicians, trainees, and researchers in the diagnosis and treatment of HCC.
Al-Musykilât Fî Dirâsati Al-Imla’ Lada Thullâbi Al-Jâmi’ah Wa Tahlîluhâ
Authors: Syamsiyah Barid
Published: December 2022

Penelitian ini bertujuan untuk mengetahui problematika pembelajaran imla’ dan pemberian solusinya pada mahasiswa PBA di IAIN Salatiga. Penelitian ini merupakan penelitian kualitatif lapangan dengan menggunakan metode observasi, wawancara  dan dokumentasi dalam pengumpulan sumber data. Teknik Analisis data penelitian menggunakan teknik analisis deskriptif. Adapun hasil penelitian menunjukkan bahwa problematika pembelajaran imla’ disebabkan oleh beberapa faktor yaitu faktor internal dan faktor eksternal. Faktor internal meliputi siswa, guru, materi dan metode pembelajaran. Adapun faktor eksternal meliputi faktor pembelajaran imla’ meliputi kaidah-kaidah pembelajaran imla’. Adapun  dalam mengatasi  problematika pada pembelajaran imla’ mahasiswa yaitu memperbanyak kosakata dan latihan menulis, perhatian yang  lebih pada kaidah-kaidah imla’ baik secara teori maupun praktek, menentukan materi  imla’ dari yang mudah dan yang sulit  serta pentingnya pengajar yang profesional yang ahli dalam pembelajaran imla’.
Developing Arabic Educational Games in ‘Arabiyah Lil Athfal Entrepreneurship Course Using Project-Based Learning
Authors: Muslimah Maziyyatul
Published: December 2022

Arabic educational games proven to have the advantages of making learning more entertaining also enhancing students' interest and excitement for learning Arabic. In light of these benefits, studies suggest that Arabic language teachers should receive training in the design, planning, implementation, and evaluation of educational games in order to enrich learning and teaching experiences, activate learner's role, and benefit from educational games to achieve targeted direct knowledges. However, there is a paucity of research on teaching prospective Arabic teachers to build Arabic instructional games, particularly in the entrepreneurial context. Using qualitative methods, this study aims to indicate the project-based learning approach utilized to create Arabic instructional games as part of Arabiyah lil Athfal Entrepreneurship course in State Islamic University (IAIN) of Kediri, East Java, Indonesia. It is found that project-based learning in Arabiyah Lil Athfal's class satisfied several defined criteria: centrality, driving question, constructive investigations, autonomy, and realism. The project was demonstrated to be a substantial component of the course and worthy of being regarded core.
Contemporary relevance of OTT platforms in the entertainment world with special reference to Indian cinema industry
Authors: Kaitharath Thankachan Jose , Nirmal Shruti
Published: December 2022

OTT platforms has increased craze in the youth and the larger audience attention due to variety in the content which focus not only on entertainment but also on the information. The major factors contributing the rise of the video streaming platforms are subscription with heavy discounts for the unlimited content, many content based work in the films in the form of documentaries in which information is given in an entertaining way. Another factor helped is the increased usage of smartphones and internet availability in the country. One of the spices of OTT is the web series which is a very trending program format. This study was carried on by the observation method, focus group study & the interview method of the research. The generalized conclusion the researcher got was that the people are more inclined to the OTT platform contents due to the ample of time available to them during COVID-19 pandemic, which worked as an inclined habit into people’s routine.
Changing values of HRM: An alternative to personal development
Authors: Karunakaran N , T. B. Chinnappa
Published: December 2022

World is more competitive, dynamic, uncertain and volatile. Many firms have to compete globally. Global competitiveness and technological innovation shifted economies based on production. Knowledge based capital requires skills and knowledge, an alternative to personal development.
El Patrimonio Vivo del Centro Histórico de Asunción: CHA mbaetee oikovéva gueteri
Authors: Casseb Marcia , Bonomo Umberto , Gambarra Thaise , Abraham Salma , Cristaldo Osvaldo
Published: December 2022

Esta publicación recopila y visibiliza un trabajo de larga trayectoria realizado en el marco del Programa Patrimonio Vivo en Asunción del Paraguay y desarrollado por la mesa interinstitucional de trabajo conformado por el equipo técnico del Banco Interamericano de Desarrollo (BID) y representantes de las instituciones locales (Ministerio Urbanismo Vivienda y Hábitat; Secretaria Nacional de Cultura; Secretaria Nacional de Turismo y Municipalidad de Asunción). Patrimonio Vivo es un programa de carácter multisectorial liderado por el BID con apoyo del Gobierno de España, orientado a impulsar la conservación y puesta en valor del patrimonio urbano material e inmaterial como catalizador para el progreso económico, ambiental y social, y como medio para fortalecer la identidad cultural y el desarrollo urbano sostenible de las ciudades de América Latina y el Caribe. El libro Patrimonio Vivo del CHA contiene parte de la información desarrollada durante el programa y se basa en los contenidos del registro oficial del patrimonio y la información levantada a partir de los talleres participativos desarrollados durante la fase inicial y diagnostica con la participaron gestores culturales, académicos y de la sociedad civil. El material de aprendizaje presenta qué y cuáles son los patrimonios identificados en el Centro Histórico de Asunción (CHA) y alrededores. Juntos revisaremos cómo está y cómo se protege el patrimonio cultural y natural; y finalmente presentaremos las principales estrategias para potenciar las riquezas patrimoniales del CHA. Este libro es una invitación a entender el patrimonio como una oportunidad para recuperar y poner en valor la riqueza y diversidad cultural y natural existente en el CHA, así como la urgencia en construir estrategias para potenciar su salvaguarda.
La evolución de los precios de los servicios de infraestructura en América Latina y el Caribe entre 2012 y 2022
Authors: Brichetti Juan Pablo , Serebrisky Tomás , Solís Ben
Published: December 2022

Los servicios de infraestructura -agua, saneamiento, energía, telecomunicaciones y transporte- son un insumo vital para el desarrollo de las personas. Los precios de estos servicios son variables fundamentales para que los usuarios decidan las cantidades que pueden consumir y para que, en el caso de los proveedores, determinen los estándares de calidad de los servicios y las inversiones que son capaces de ejecutar para aumentar el acceso, entre otros aspectos. Este documento utiliza la información de los Indices de Precios al Consumidor (IPC) de siete países de la región (Argentina, Brasil, Chile, Colombia, México, Perú y República Dominicana) y analiza las variaciones experimentadas por los precios de los servicios de infraestructura en el periodo 2012-2022.
No Time for Later: Rebuilding Macro Buffers in the Southern Cone amid a Revamped Global Financial Landscape
Authors: Rodrigues Bastos Fabiano , Gutiérrez Diego , Queijo Von Heideken Virginia
Published: December 2022

Global financial shocks under a revamped global financial landscape can produce unexpected, multi-faceted, and disruptive implications for emerging market economies. Using the VIX index as a proxy for global financial stress, we argue that Southern Cone macro conditions can undergo significant pressure under adverse global financial shocks. The region needs to start rebuilding macro buffers now -in addition to simultaneously correcting macro imbalances and enhancing policy frameworks- to cope with the emerging global financial environment. International organizations, including multilateral development banks, can play several key roles in supporting the rebuilding of macro buffers.
El potencial del esquema de reciclaje de activos en América Latina y el Caribe y su racionalidad económica bajo un enfoque teórico: tarificar más allá del período de autofinanciamiento
Authors: Muñoz Roberto , Hinojosa Sergio Alejandro , Mascle-Allemand Anne-Laure , Mansilla Patricio , Moraga Enrique
Published: December 2022

Con el apoyo de Gobiernos e instituciones de investigación de América Latina y el Caribe, desde el BID desarrollamos en 2020 la Red de Análisis y Buenas Prácticas en Asociaciones Público-Privadas (Red APP), con el objetivo de mejorar el desarrollo de infraestructura en la región en términos de calidad, sostenibilidad, competitividad, y eficiencia. La Red APP nace con el objetivo de A) conectar las demandas públicas de conocimiento con la investigación aplicada desarrollada (en otras palabras, que los trabajos analíticos en materia de APPs respondan a lo que los desarrolladores de políticas y proyectos quieren saber sobre qué funciona y qué no); B) sistematizar la información: mediante la generación de información sistematizada para el análisis de proyectos, desde las decisiones de inversión hasta las de financiamiento; C) generar y coordinar la evidencia existente: mediante el desarrollo de trabajos analíticos a partir de información pública disponible generada por la red, así como conectar la investigación aplicada regional para potenciar sinergias en la generación de conocimiento. A comienzos de 2020, y partir de una Consulta Pública a Gobiernos de la región, se determinaron una serie de temas de interés comunes en el desarrollo de infraestructura mediante APP en torno a cinco grandes áreas: Regulación e Institucionalidad, Factibilidad y Estructuración de Proyectos Sostenibles, Financiamiento de Proyectos, Gestión de Riesgos y Monitoreo, y Evaluación, Desempeño e Impacto. El presente trabajo “El potencial del esquema de reciclaje de activos en América Latina y el Caribe y su racionalidad económica bajo un enfoque teórico: Tarificar más allá del período de autofinanciamiento" responde a dicha demanda y ha sido seleccionado a través de una convocatoria competitiva de propuestas.
Metodología para el estudio de la movilidad con datos de Facebook: generación de matrices origen-destino en ciudades de América Latina y análisis para Buenos Aires
Authors: Fulponi Juan Ignacio , Moleres Cristian
Published: December 2022

El conocimiento de las características y patrones de desplazamiento de las personas en las ciudades es un insumo clave para la definición de políticas públicas de movilidad urbana, especialmente en las grandes áreas metropolitanas. Desafortunadamente, es baja la disponibilidad de datos actualizados y confiables en muchas de las ciudades de América Latina y el Caribe (ALC), y su generación por métodos de estudio tradicionales requieren grandes esfuerzos por parte de los gobiernos locales para su recolección y procesamiento. Por este motivo, investigar nuevas fuentes de información que aprovechen los datos masivos generados por aplicaciones de dispositivos móviles se convierte en un objetivo clave para resolver esta problemática. El Observatorio de Movilidad Urbana de América Latina (OMU) busca dar respuesta esta necesidad de información sólida, confiable y actualizada sobre el transporte y la movilidad urbana en la región. En este trabajo se utilizaron bases de datos de la aplicación Facebook, obtenidos a través del programa Data for Good en colaboración con el Development Data Partnership y el Departamento de Transporte de la Facultad de Ingeniería de la Universidad de Buenos Aires, para elaborar una metodología que genere matrices origen-destino en las grandes áreas metropolitanas de ALC que forman parte del OMU. Estas matrices representan los desplazamientos que realiza la población entre sus residencias y las actividades principales (trabajo, estudio, etc.) durante las horas de la mañana en abril-mayo del año 2022. Además, se realizó un análisis detallado de los resultados obtenidos en la Región Metropolitana de Buenos Aires (RMBA). Se estudió la relación entre las distancias de desplazamiento y variables geográficas y socioeconómicas de la metrópolis, y se comparó los resultados obtenidos con otros datos y estudios disponibles.
Análisis de datos utilizando el lenguaje de programación R: una experiencia de aprendizaje virtual en el aula invertida
Authors: Reu Björn , Duran-Barajas Yovanny , Villamizar-Gómez Zarith Tatiana , Ardila-Hurtado Silvia Fernanda , Remolina-Ayala Juan Camilo , Bolívar-Santamaría Sergio Andrés
Published: December 2022

En años recientes, R se ha vuelto una herramienta indispensable para el análisis de datos en muchas áreas de las ciencias básicas, aplicadas y en la industria. En lugar de aprender múltiples herramientas, los estudiantes pueden utilizar un entorno único para una gran diversidad de métodos de análisis de datos. Más que un lenguaje de programación, R ofrece nuevas vías para la enseñanza de la estadística, debido a que los problemas de análisis de datos pueden ser desarrollados paso a paso y analizados de manera transparente y reproducible, p.ej. usando R Markdown. Esto permite un aprendizaje interactivo y orientado a resolver problemas, combinando la teoría y la práctica.
La Representación Gráfica
Authors: Morales-Dimarco Juan Carlos
Published: December 2022

El Objeto Virtual de Aprendizaje desarrollado hace parte de una estrategia pedagógica que implementa las nuevas tecnologías de información en el desarrollo de los temas de la asignatura “Geometría Descriptiva”, utiliza un conjunto de estrategias didácticas que se integran en un aula virtual de aprendizaje junto con una serie de recursos digitales audiovisuales.
Practicas microbiológicas para farmacia
Authors: Plata-Planidina Diana Mabel
Published: December 2022

Este OVA ha sido diseñado pensando en la dificultad que presentan los estudiantes para entender el desarrollo de las prácticas de laboratorio debido a que los anexos explicativos de cada laboratorio no especifican el procedimiento desarrollado durante la misma. Con el empleo de este material se pretende apoyar el conocimiento de los grupos microbianos y las normas básicas de recolección de las muestras para que el estudiante pueda desarrollar el informe de laboratorio de cada una de las prácticas presentando unas conclusiones que reúnan la importancia de las mismas durante su desempeño como futuro Regente de Farmacia.
A Non-Cooperative Distributed Model Predictive Control Using Laguerre Functions for Large-Scale Interconnected Systems
Authors: Menighed Kamel , Yamé Joseph Julien , Chekakta Issam
Published: December 2022

This paper deals with a new non-cooperative distributed controller for linear large-scale systems based on designing multiple local Model Predictive Control (MPC) algorithms using Laguerre functions to enhance the global performance of the overall closed-loop system. In this distributed control scheme, that does not require a coordinator, local MPC algorithms might transmit and receive information from other sub-controllers by means of the communication network to perform their control decisions independently on each other. Thanks to the exchanged information, the sub-controllers have in this way the ability to work together in a collaborative manner towards achieving a good overall system performance. To decrease drastically the computational load in the small-size optimization problem with a short prediction horizon, discrete-time Laguerre functions are used to tightly approximate the optimal control sequence. For evaluating the proposed distribution control framework, a simulation example is proposed to show the effectiveness of the proposed scheme and its applicability for large-scale interconnected systems. The obtained simulation results are provided to demonstrate clearly that the proposed Non-Cooperative Distributed MPC (NC-DMPC) outperforms Decentralized MPC (De-MPC) and achieves performance comparable to centralized MPC with a reduced computing time. The system performance of the proposed distributed model predictive control is given.
Robust Nonlinear Control Design for the HVAC System Based on Adaptive Sliding Mode Control
Authors: Hassan Maha Raad , Al-Samarraie Shibly Ahmed
Published: December 2022

Control of Heating, Ventilating, and Air Conditioning (HVAC) aims to provide a comfortable environment for human life in terms of temperature and humidity and improve indoor air quality. The HVAC system is multi-input multi-output, where the control design of this system is challenging due to its strong nonlinearity and the coupled influence of both system controllers on the temperature within the thermal zone. The aim of this study is to design a dual-controller for the HVAC system. The first controller is a non-linear feedback controller which is devoted to control the humidity ratio of the thermal zone with the desired characteristic. While for the second one, a robust controller is designed to maintain the desired thermal zone temperature based on the adaptive sliding mode controller (ASMC). Using the ASMC enabled us to design the second controller without the need to know the uncertainty bound on the HVAC system model. Additionally, the stability of the proposed control system was verified using the Lyapunov theory. To construct the sliding variable for the temperature control, the error state which is the difference between the thermal zoon temperature and the desired value and its derivative is needed. Due to the uncertainty in the error state derivative, a robust differentiator was designed using the approximate classical sliding mode differentiator (ACSMD). Finally, the performance of the control system is confirmed via numerical simulation. The results showed the robust ability of the control system to make the humidity and temperature of the thermal area follow the required values and with high accuracy.
A Barrier Function-Based Variable Structure Control for Maglev System
Authors: MohammadRidha Taghreed , Kadhim Mina Qays
Published: December 2022

Magnetic levitation (Maglev) systems are widely employed in the industry especially in mechatronics systems for precise positioning and suspension. They are inherently unstable having nonlinear models with uncertain parameters and exposed to external disturbances. Therefore, high-performance robust control designs are recommended for these systems. An Adaptive Variable Structure Controller based on barrier function (AVSCbf) is designed for the first time in this work to control the displacement of the ball position of a disturbed Maglev system. This approach does not require prior knowledge of the disturbance upper bounds in the design procedure. The state space region defined by the barrier function is designed to be attractive and invariant. This feature is essential to reject disturbances and handle parametric uncertainties. The adaptive law is activated when the state trajectory is initiated outside the invariant set defined by the barrier function. The gain of the VSC is adapted according to an adaptation law, which considers the system input constraints. The control input is constrained to be a bounded positive quantity. The adaptive VSC is only applied during the reaching phase. Once the state reaches the invariant set, the barrier-function-based VSC is applied to confine the state inside it. The resulting overall controller is a chattering-free VSC since the barrier-function based VSC is continuous. The steady-state error is limited to a minimal value by only specifying the barrier function parameter. Numerical simulations are conducted to show the efficiency of the new approach. Three types of VSC controllers for the Maglev system are compared. AVSCbf is compared to the performance of adaptive only VSC without the barrier function (AVSC) and both are designed in this work. AVSCbf is also compared to the classical VSC performance from previous work in the literature. The results of the comparison showed the efficiency of the proposed controller.
Using the Model Reduction Techniques to Find the Low-Order Controller of the Aircraft's Angle of Attack Control System
Authors: Thanh Bui The , Trung Ngo Kien
Published: December 2022

The problem of controlling the angle of attack of the aircraft is one of the difficult and complex problems due to the problems of nonlinear kinematics, variable parameters and uncertainty model. The design of the angle of attack control according to the robustness control algorithm often leads to a higher order robustness controller. Using a higher-order controller has many disadvantages, so it is necessary to have solutions to reduce the order of the controller. This paper presents the idea of designing a low-order controller for the aircraft's angle of attack control system using the order reduction algorithm. In order to meet the requirements of performance and stability when parameters change, the optimal controller of the aircraft's angle of attack is usually of high order. The paper has used order reduction algorithms to reduce the order of high-order angle of attack controller, the results show that: 4th-order controller or 1st-order controller can be used instead of high order controller. Using a low-order controller to control the aircraft's angle of attack shows that the quality of the control system is comparable to that of a high-order controller.
Robust Control Simulation and Implementation for DC Motor
Authors: Ameur Fatima , Ameur Takieddine , Ameur Khadidja
Published: December 2022

The sliding mode controller has been suggested to achieve robust performance against parameter variations and load disturbances. It also offers a fast dynamic response, stable control system and easy hardware-software implementation. This paper focuses the application of this approach to the adjustment of a speed control DC motor, in Matlab Simulink simulation and Arduino hardware implementation, The main goal of this paper is to improve the performances of DC motor controlling by sliding mode. In first the modeling of DC motor is well explained in this paper, is important step for control of system, secondly the basic theory regarding sliding mode controller SMC using Lyapunovis function is presented. Finley the application of SMC using Matlab simulation and Arduino implementation for DC motor, the results show that SMC has a better performance compared to PI which is faster settling time and no overshoot and undershoot, could be used as an alternative controller for the DC Motor.
Сharacteristics calculation procedure for the nonlinear hydraulic chains with pulsating working media
Authors: Shorin V. P. , Shakhmatov E. V. , Gimadiev A. G.
Published: December 2022

The article describes a technique developed by the authors to calculate the static and dynamic errors of the hydraulic chains caused by nonlinear averaging pressure pulsations. Given an example of calculating the deviation of the engine automatic control chain characteristics due to the influence of pressure fluctuations at the output of the fuel pump gear.

Keywords: Nonlinear hydraulic chain, pressure fluctuations, error, calculation method, engine, regulator, startup characteristic, deflection of the characteristics
INCREASING THE SERVICE LIFE OF THE CONSTRUCTIVE ELEMENTS OF THE HYDRO-PNEUMATIC FIXTURES FOR CRAFTS AND FLIGHT-TYPE ENGINES
Authors: Kondrashov Yuri I. , Ermilova Elena N. , Vidyaskina Anna N.
Published: December 2022

The article discusses methods for estimation the loaded deformation state of structural elements of hydro-pneumatic fixtures using modern software application. It also shows a complex approach to the use of constructive and technological methods of increasing the durability of details. The possibility of using the method of diamond burnishing is considered on the example of hardening the surface of the valve body and flang. Also, this method is compared with other known technological methods of surface hardening.