bluuebunny/crossref_metadata_2025 huggingface dataset:
Initial Studies on the Effect of the Rice–Duck–Crayfish Ecological Co-Culture System on Physical, Chemical, and Microbiological Properties of Soils: A Field Case Study in Chaohu Lake Basin, Southeast China
Authors: Yan Jun , Yu Jingwei , Huang Wei , Pan Xiaoxue , Li Yucheng , Li Shunyao , Tao Yalu , Zhang Kang , Zhang Xuesheng
Published: January 2023

Rice–duck and rice–crayfish co-culture patterns can increase soil productivity and sustainability and reduce the use of chemical pesticides and fertilizers, thereby reducing the resulting negative environmental impacts. However, most studies have focused on the rice–duck and rice–crayfish binary patterns and have ignored integrated systems (three or more), which may have unexpected synergistic effects. To test these effects, a paddy field experiment was carried out in the Chaohu Lake Basin, Hefei city, Southeast China. Four groups, including a rice–duck–crayfish ecological co-culture system (RDC), idle field (CK), single-season rice planting system (SSR), and double-season rice planting system (DSR), were established in this study. The results showed that the RDC improved the soil physical properties, fertility, humus content, and enzyme activity. In the RDC system, the soil total nitrogen content ranged from 8.54% to 28.37% higher than other systems in the 0-10 cm soil layer. Similar increases were found for soil total phosphorus (8.22–30.53%), available nitrogen (6.93–22.72%), organic matter (18.24–41.54%), urease activity (16.67–71.51%), and acid phosphatase activity (23.41–66.20%). Relative to the SSR treatment, the RDC treatment reduced the total losses of nitrogen and phosphorus runoff by 24.30% and 10.29%, respectively. The RDC also did not cause any harm to the soil in terms of heavy metal pollution. Furthermore, the RDC improved the yield and quality of rice, farmer incomes, and eco-environmental profits. In general, the RDC can serve as a valuable method for the management of agricultural nonpoint-source pollution in the Chaohu Lake area and the revitalization of the countryside.
Urban Itineraries with Smartphones to Promote an Improvement in Environmental Awareness among Secondary School Students
Authors: Álvarez-Herrero Juan-Francisco
Published: January 2023

Our world is undergoing a series of changes that are taking it to an unsustainable situation. In addition to alerting the population, we must seek education towards a more sustainable world. This research proposes the realization in Alcoy (Spain) of some urban itineraries with mobile devices and with secondary school students, in order to promote an improvement in awareness and action on environmental problems. This activity aims, among other objectives, through informal learning and outside the classroom, to raise awareness among secondary school students about the environmental problems that threaten us. With the completion of a questionnaire, after carrying out these urban itineraries, the results of 214 students confirm that, with this type of activity, there is a notable improvement in the level of awareness and concern for environmental problems. It is also detected that men prefer these types of environmental awareness tests, compared to women, who prefer tests that have a more creative and artistic theme. It is worth continuing to propose this type of activity among students and improve their approach by forecasting, planning, and improving the training of the teachers involved in it.
“Maybe it’s Not Just the Food?” A Food and Mood Focus Group Study
Authors: Lee Megan F. , Angus Douglas , Walsh Hayley , Sargeant Sally
Published: January 2023

Epidemiological and intervention studies in nutritional psychiatry suggest that the risk of mood disorders is associated with what we eat. However, few studies use a person-centred approach to explore the food and mood relationship. In this qualitative study of 50 Australian participants, we explored individuals’ experiences with food and mood as revealed during focus group discussions. Using a thematic template analysis, we identified three themes in the food and mood relationship: (i) social context: familial and cultural influences of food and mood, (ii) social economics: time, finance, and food security, and (iii) food nostalgia: unlocking memories that impact mood. Participants suggested that nutrients, food components or food patterns may not be the only way that food impacts mood. Rather, they described the social context of who, with, and where food is eaten, and that time, finances, and access to healthy fresh foods and bittersweet memories of foods shared with loved ones all impacted their mood. Findings suggest that quantitative studies examining the links between diet and mood should look beyond nutritional factors and give increased attention to the cultural, social, economic, and identity aspects of diet.
Preliminary Assessment of the Quality of Life and Daily Burden of Caregivers of Persons with Special Needs: A Questionnaire-Based, Cross-Sectional Survey
Authors: Cardoso Andréa Lanzillotti , Silva-Junior Geraldo Oliveira , Bastos Luciana Freitas , Cesar Ana Luiza Medeiros , Serrano Leila Goes , Dziedzic Arkadiusz , Picciani Bruna Lavinas Sayed
Published: January 2023

Caregivers of persons with special needs (PSN) experience a variety of burdens and elevated levels of stress and anxiety throughout their lives, leading to a physical, psychological, emotional, social, and financial overload. This analytical study with a cross-sectional design and a quantitative approach aimed to appraise quality of life (QoL), reflecting the daily workload of informal family caregivers of PSN. Methods: Four structured, validated questionnaires were utilised: sociodemographic, WHOQOL-bref, Zarit Burden Interview, and Functional Independence Measure Scale in 60 anonymous volunteered respondents. Results: The informal caregivers were middle-aged mothers (81.7%), married (55%), stay-at-home spouses (60%) with high school degrees (51.6%), providing a care for their relatives with special needs for more than 20 years (41.8%). Most of the PSN were diagnosed with autistic spectrum disorder (ASD, 61.8%), had a wide spectrum of intellectual deficits, and required constant support for their basic needs. They were mainly adolescent males without physical limitations (83.4%) on disorder-specific medications (90%). The study revealed that those caregivers had a median perception of QoL considering four essential domains, with a highest score recorded for the physical domain (64.3 +/− 16.1 SD). A moderate burden level prevailed, revealing neither a correlation between the workload expressed by caregivers and the patient’s functional capacity, nor in the performance of daily self-care tasks (Spearman correlation test p > 0.05), apart from the environmental domain (mild correlation = 0.335, p < 0.05). Conclusions: The reported average level of overload associated with QoL of informal caregivers exists, affecting a vast proportion of the respondents. The absence of a direct association between workload and the functional capacity/daily self-care tasks can be related to the significant personal dedication of family caregivers, regardless of their socioeconomic status.
Determinants of Sleep Quality: A Cross-Sectional Study in University Students
Authors: Schmickler Johanna Marie , Blaschke Simon , Robbins Rebecca , Mess Filip
Published: January 2023

When entering the university setting, poor sleep quality is reportedly prevalent among students and has been linked to a range of adverse health outcomes, including reduced academic performance. Moreover, determinants of sleep quality are not yet fully understood. This study was designed to (1) assess the prevalence of poor sleep quality and (2) identify determinants of sleep quality in German university students. In total, 1,684 undergraduate and graduate students (50.6% female, mean age 22.87 ± 3.15 years) from multiple academic disciplines completed a cross-sectional online survey assessing socio-demographic, health, and study-related indicators and sleep quality using the Pittsburgh Sleep Quality Index (PSQI). In our sample, 820 (48.7%) met the PSQI cut-off score (>5) for poor sleep quality. Multiple regression analysis showed that older age, being a business student, lower subjective social status, poorer self-rated health, stress, exhaustion, and poor academic performance significantly predicted poor sleep quality. Our findings document a high prevalence of poor sleep quality among university students and suggest that business students, especially, might be exposed to a greater risk for poor sleep quality. Furthermore, the results of this study are valuable for academic staff to develop tailored interventions to promote healthy sleep-in university students.
Silencing the Rainbow: Prevalence of LGBTQ+ Students Who Do Not Report Sexual Violence
Authors: Tillewein Heather , Shokeen Namrata , Powers Presley , Rijo Sánchez Amaury J. , Sandles-Palmer Sasha , Desjarlais Kristen
Published: January 2023

Previous research on sexual violence suggests that there is a higher likelihood of students from LGBTQ+ community experiencing sexual violence and not reporting it. This study investigates various types of sexual violence experienced by the LGBTQ+ students and the prevalence of reporting it. The study further determines why different types of sexual violence are not being reported. This study uses a LGBTQ+ scholarship survey data conducted in 2019. Using Pearson’s chi square analysis, the study investigates the relationship between who experienced various kinds of sexual violence and those who do not report it. The study provides descriptive analysis of reasons for not reporting sexual violence across different types of sexual violence. The results show that there is a statistically significant relationship between those who experienced various kinds of sexual violence and those who do not report it. In addition, the study illustrates mistrust in support services and fear of embarrassment as the major reasons resulting in non-reporting behaviors. In conclusion, the study illustrates high prevalence for various types of sexual violence against LGBTQ+ students as well as high underreporting. Study results have implications for health professionals and institutions to focus efforts in making school environments safe and inclusive for LGBTQ+ students.
The Impact of Non-Physical Education Teachers’ Perceptions on the Promotion of Active and Healthy Lifestyles: A Cross-Sectional Qualitative Study
Authors: Gomes Lúcia , Martins João , Ramos Madalena , Carreiro da Costa Francisco
Published: January 2023

(1) Background: In accordance with the socio-ecological model of physical education (PE), school-based interventions to promote physical activity (PA) will only be successful if a change occurs in the perceptions and attitudes of all. This study sought to analyze non-PE teachers experiences in PE and how these experiences relate to the value they attribute to PE, sports and PA, and the impact of teachers’ perceptions on promoting active lifestyles in the school’s context. A mixed-method study was adopted. (2) Methods: A survey about the perceptions in PE was applied to 297 teachers (58 male). From this sample, 24 teachers were selected for three focus groups considering their experiences in PE (e.g., good experiences, bad experiences). MaxQda was used for the inductive qualitative data analysis. (3) Results: Teachers who have had good experiences in PE value the role of PE and sports. Teachers who have had bad experiences do not value the importance of PE or sports. (4) Conclusions: The results support the importance of having good experiences in PE to generate positive attitudes. Thus, teachers who have had bad experiences in PE may constitute barriers that will hinder the promotion of an educational climate that promotes PA and active lifestyles in schools.
Exploring Syrian Refugees’ Access to Medical and Social Support Services Using a Trauma-Informed Analytic Framework
Authors: Moayerian Neda , Stephenson Max , Abu Karaki Muddather , Abbadi Renad
Published: January 2023

Even after arrival in new countries, refugees may be exposed to traumatic events. This state is exacerbated by contextual stressors, including the resettlement process, asylum proceedings and threats of deportation. This paper is rooted in a trauma-informed framework. We interviewed 16 male Syrian refugee migrant workers employed on a Jordanian farm during crop harvesting season to explore the quality and level of medical care and mental health services they received in light of the framework’s principal dimensions (e.g., safety, trust, intersectionality). We found that this vulnerable group of individuals is living a marginal and marginalized existence and depends on the goodwill of the growers for whom they work to treat them with a modicum of dignity and respect. Second, their itinerancy makes it difficult for this population to take advantage of available medical and mental health services at the nation’s major refugee camps. Finally, our interlocutors preferred their current lives, as isolating and limiting as they are, as superior to full-time residence in the camps, because they perceive their present way of life as according a measure of dignity, self-direction and autonomy they could not enjoy in the camps.
Mental Health and Homelessness in the Community of Madrid (Spain): The Impact of Discrimination and Violence
Authors: de la Fuente-Roldán Iria Noa , Corchado-Castillo Ana Isabel , Dorado-Barbé Ana
Published: January 2023

The aim of this study was to analyze the impact of experiences of violence and discrimination on mental health among people in situations of homelessness (PSH). For this purpose, a quantitative, descriptive, and correlational investigation was conducted by conducting a survey with 603 PSH living in the Community of Madrid (Spain). The results show high levels of mental health impairment, as well as approximately half of the participants having experienced discrimination and violence in the course of their homelessness. Perceived experiences of discrimination are associated with higher levels of mental health impairment (OR = 0.458; p = < 0.001; 95% IC 0.31–0.68). This deterioration is also related to a negative self-assessment of the general state of health among participants (OR = 0.262; p = < 0.001; 95% IC 0.12–0.57). However, impaired mental health is not associated with experiences of violence. The findings also indicate that there are intersections in terms of being female, young, and foreign that result in greater psychological impairment and a higher risk of experiencing violence and discrimination. This study provides an insight into the PSH experiences in relation to mental health, violence, and discrimination and the need to implement actions aimed at improving their psychosocial wellbeing from the perspective of respect for citizens’ rights.
Persistent Organic Pollutants (POPs) in Sardine (Sardinella brasiliensis): Biomonitoring and Potential Human Health Effects
Authors: Massone Carlos German , dos Santos Allan Amendola , Ferreira Pedro Gonçalves , Carreira Renato da Silva
Published: January 2023

Organochloride (OC) and polychlorinated biphenyl (PCB) concentrations were determined in the muscle tissue of fifty sardine samples (Sardinella brasiliensis) sampled off the south-east Brazilian shelf. The aim herein was to investigate OCs and PCBs composition profile, bioaccumulation potential and human risks. The concentrations of 18 organochlorine pesticides (OCPs) were below the method limit of quantification in most samples (ca. 94%), with few detected, namely δ-HCH, γ-HCH, Endosulfan I and II, Endosulfan Sulphate, DDE, Dieldrin, Endrin, Endrin Aldeide, Endrin Cetone and Metoxyclor. The median concentration for the Σ41 PCBs was 2.32 ng g−1, ranging from values below the limit of quantification (<LOQ) to 37.2 ng g−1. Based on the analyzed samples, the concentrations reported herein do not represent a risk for human consumption according to both national and international guidelines, nor do OC and PCB bioaccumulation in sardines appear to be a concern at the moment. These findings, although preliminary, represent a baseline for future comparisons of the quality of an important source of protein available to the poorest Brazilian population strata.
Let’s Talk about Sex… and ADHD: Findings from an Anonymous Online Survey
Authors: Young Susan , Klassen Larry J. , Reitmeier Shayne D. , Matheson Jake D. , Gudjonsson Gisli H.
Published: January 2023

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity and impulsivity. A dearth of studies have investigated psychosexuality in this population, often with few (predominantly male) participants. We recruited individuals with and without ADHD via an anonymous online survey distributed electronically by ADHD support organizations and social media. We investigated sexual history; interests and practices; and relationships. Of 1392 respondents, we classified an ‘ADHD’ group (n = 541; 30.5% male) and compared them to individuals of similar ages without ADHD, (‘Other’ group; n = 851; 37.6% male). The ADHD group (both males and females) had a significantly higher preference for same-sex or either-sex partners; and higher rates of electronic sexual exchanges, masturbation, and sexually transmitted diseases. They were more adventurous in sexual interests and practices and substantially less satisfied with their partners, both sexually and generally. Within the ADHD group, significant sex differences emerged: females had younger onset of sexual activities, used contraception less frequently, had more sexual partners and practiced more infidelity. Sexual interests differed between the sexes, but females more commonly acted on them, whereas males did not. Findings suggest both sexes engage in risky sexual behaviors, perhaps driven by impulsivity, but risk is substantially greater for females with ADHD.
Relationship between Strength and Professional Quality of Life of Nurses Working Hospital Emergency Departments
Authors: Córdova-Martínez Alfredo , Pérez-Valdecantos Daniel , Caballero-García Alberto , Bello Hugo J. , Roche Enrique , Noriega-González David
Published: January 2023

Optimal quality of professional life can allow coping with stressful situations and avoiding fatigue. This is instrumental in jobs undergoing very demanding situations, such as nurses working in Emergency Departments. In this study, we investigated the relationship between functional and physiological indicators and the quality of professional life in nurses of Emergency Departments of two public hospitals. Fifty-nine professionals participated in the study. Cortisol (an indicator of stress) and post-test lactate (an indicator of fatigue) were analyzed in saliva and in the blood, respectively, at the beginning and at the end of the morning shift. The CVP-35 survey (Spanish version of the QPL-35 questionnaire) was used to assess the quality of professional life. Post-dynamometry circulating lactate levels increased significantly; meanwhile, salivary cortisol decreased in participants at the end of the working shift. Regarding dynamometry, no significant changes were observed. CVP-35/QPL-35 scores did not show significant changes in participants from both hospitals in all dimensions analyzed. In conclusion, nurses participating in the study displayed adaptation to stress accompanied by an acceptable level of professional quality of life. However, certain fatigue appears at the end of the working day. Altogether, results suggest that a better organization must be implemented at work, improving ergonomic, safe, and healthy conditions.
Family–SEN School Collaboration and Its Importance in Guiding Educational and Health-Related Policies and Practices in the Hungarian Minority Community in Romania
Authors: Dan Beáta Andrea , Kovács Karolina Eszter , Bacskai Katinka , Ceglédi Tímea , Pusztai Gabriella
Published: January 2023

Special education practice allows for the educational principles of parental involvement, pointing to a common dialogue on health issues and general well-being. Special education professionals primarily empower the families of children with atypical development by relying on the organizational factors of individual support and services. The decision-making/partnering factors of the educational and general health processes, on the other hand, receive less attention. The present study aims to explore the place of the parent–school relationship within the framework of a special educational institution in Romania. Involving Hungarian special education teachers (N = 12) from Romania, we analyze the school involvement of the parents of students with special educational needs in Bihor County, Romania, concerning their children’s academic achievement and well-being. The qualitative research data were recorded through semistructured interviews and were organized through deductive categorization, as well as being analyzed thematically using Atlas.ti. The results highlighted the essential elements of the parent–school relationship, e.g., communication practices, active inclusion programs, support services, and peer acceptance plans. We believe it is important to emphasize that, in the study, families frequently better understood their child’s situation and health-related issues and advocated more effectively for the recognition of their rights. However, as an active player in everyday education, the teacher can better organize development activities for the child’s specific needs and plan complex habilitation/rehabilitation. To sum up, a parent–educator team approach can result in more successful educational and health outcomes, as well as a more accepting social image in the cognitive, emotional, and social development fields.
Associations between Different Ozone Indicators and Cardiovascular Hospital Admission: A Time-Stratified Case-Crossover Analysis in Guangzhou, China
Authors: Zhang Xiangxue , Maji Kamal Jyoti , Wang Zhuoqing , Yang Fiona Fan , Wang Guobin , Cheng Changxiu
Published: January 2023

Epidemiological studies reported that ozone (O3) is associated with cardiovascular diseases. However, only few of these studies examined the impact of multiple O3 indicators on cardiovascular hospital admissions. This study aimed to explore and compare the impacts of different O3 indicators on cardiovascular hospital admissions in Guangzhou, China. Based upon the data on daily cardiovascular hospital admissions, air pollution, and meteorological factors in Guangzhou from 2014 to 2018, a time-stratified case-crossover design model was used to analyze the associations between different O3 indicators and cardiovascular hospital admissions. Moreover, the sensitivities of different age and gender groups were analyzed for the whole year and different seasons (i.e., warm and cold). During the warm season, for the single-pollutant model, the odds ratio (OR) value of cardiovascular hospital admissions was 1.0067 (95% confidence interval (CI): 1.0037, 1.0098) for every IQR increase in MDA8 O3 at a lag of five days. The effect of O3 on people over 60 year was stronger than that on the 15–60 years age group. Females were more sensitive than males to O3 exposure. These results provided valuable references for further scientific research and environmental improvement in Guangzhou. Given that short-term O3 exposure poses a threat to human health, the government should therefore pay attention to prevention and control policies to reduce and eliminate O3 pollution and protect human health.
Evaluation of Undergraduate Learning Experiences in Pediatric Dentistry during the COVID-19 Pandemic
Authors: Pawlaczyk-Kamieńska Tamara , Opydo-Szymaczek Justyna , Torlińska-Walkowiak Natalia , Buraczyńska-Andrzejewska Beata , Andrysiak-Karmińska Kinga , Burchardt Dorota , Gerreth Karolina
Published: January 2023

The aim of the study was to analyze students’ opinions on the learning outcomes they achieved during clinical classes in pediatric dentistry. The classes were run in various periods: before the SARS-CoV-2 coronavirus pandemic (onsite classes), in the first months of the pandemic (online classes), and in the following months of the pandemic (onsite classes with additional infection control and administrative changes in patients’ admission procedures). Material and methods. The research was conducted among fifth-year dentistry students at Poznan University of Medical Sciences. Students who completed the entire course and passed the diploma exam in pediatric dentistry were asked to complete the anonymous questionnaire providing their opinion. Results. The research results showed that, in the students’ opinion, clinical classes—regardless of their form—allowed them to achieve the knowledge necessary to perform pediatric dental procedures. However, the students appreciated onsite classes significantly more compared to information and communication technologies (ICT) classes in gaining practical skills and social competence. Conclusions. (1) The significant limitations introduced because of the SARS-CoV-2 pandemic impacted the development and implementation of modern online teaching techniques, which may very well be applied to convey theoretical knowledge after the pandemic has ended. (2) Skills and social competence, indispensable in the future dental practice of dental students, can only be obtained during onsite classes. (3) Medical universities should design standards of teaching to enable them to address a possible epidemiological threat in the future, which will enable rapid response and safe continuation of practical dental education during a pandemic.
Self-Assessed Threshold Temperature for Cold among Poultry Industry Workers in Thailand
Authors: Laohaudomchok Wisanti , Phanprasit Wantanee , Konthonbut Pajaree , Tangtong Chaiyanun , Sripaiboonkij Penpatra , Ikäheimo Tiina M. , Jaakkola Jouni J. K. , Näyhä Simo
Published: January 2023

The self-assessed threshold temperature for cold in the workplace is not well known. We asked 392 chicken industry workers in Thailand what they regard as the cold threshold (CT) and compared subgroups of workers using linear and quantile regressions by CT sextiles (percentiles P17, P33, P50, P67, and P83, from warmest to coldest). The variables of interest were sex, office work, and sedentary work, with age, clothing thermal insulation, and alcohol consumption as adjustment factors. The mean CT was 14.6 °C. Office workers had a 6.8 °C higher mean CT than other workers, but the difference ranged from 3.8 °C to 10.0 °C from P17 to P83. Sedentary workers had a 2.0 °C higher mean CT than others, but the difference increased from 0.5 °C to 3.0 °C through P17–P83. The mean CT did not differ between sexes, but men had a 1.6–5.0 °C higher CT at P17–P50 (>20 °C) and a 5.0 °C lower CT at P83 (<10 °C). The CT was relatively high at warm (≥10 °C), dry (relative humidity <41%), and drafty (air velocity > 0.35 m/s) worksites. We conclude that office, sedentary, and female workers and those working at warm, dry, and draughty sites are sensitive to the coldest temperatures, whereas male workers are sensitive even to moderate temperatures.
The Role of Social Media in Internalizing Body Knowledge—A Cross-Sectional Study among Women with Different Food Preferences
Authors: Krupa-Kotara Karolina , Grajek Mateusz , Rozmiarek Mateusz , Malchrowicz-Mośko Ewa , Staśkiewicz Wiktoria , León-Guereño Patxi , Aguirre-Betolaza Aitor Martínez , Castañeda-Babarro Arkaitz
Published: January 2023

Virtual spaces, such as social media, give people a platform to exchange their opinions, experiences, and knowledge. Social media’s ubiquitous usefulness has led to people relying, in whole or in part, on the information they learn online. As a result, a person’s perception of his or her own body and their self-worth has started to be influenced by what other people think of them and by the information found on social media. Modern people’s lifestyle, particularly their eating habits and exercise habits, exhibits a similar tendency. The purpose of this study was to evaluate the relationships occurring between factors related to the use and internalization of body image knowledge contained in social media and the factors shaping self-assessment and self-esteem in women following a vegetarian diet. An authority-validated questionnaire was used to determine the level of use and attitudes of respondents toward social media, e.g., SATAQ and BES. Associations about the potential negative impacts of the knowledge provided by social media on the development of body image and self-esteem were shown. It is interesting to observe that women who practice vegetarianism have less pressure on their appearance. This may be because vegetarianism is a lifestyle that is currently actively promoted online. Education is required on the connection between the use and internalization of social media knowledge and the development of healthy self-esteem and body evaluation.
The Healthcare Relationship during the Second Wave of the COVID-19 Pandemic: A Qualitative Study in the Emergency Department of an Italian Hospital
Authors: Cipolletta Sabrina , Previdi Sara , Martucci Simona
Published: January 2023

The COVID-19 pandemic had an impact not only on people’s lives but also on the healthcare system. This study aimed to investigate the healthcare relationship in the Emergency Department (ED) of a hospital in northern Italy, during the second wave of the COVID-19 pandemic. The participants (N = 43) consisted of 16 nurses, 6 doctors from the hospital ED, and 21 patients who accessed this department. Semi-structured interviews were carried out and a thematic analysis was conducted. The findings suggest that the COVID-19 pandemic brought both positive and negative changes to the healthcare relationship that are linked to changes in the organization of the ED and to participants’ various experiences of the pandemic. The changes in this relationship should be monitored because they could have long-term effects on healthcare professionals’ wellbeing, treatment outcomes, and the healthcare system. The findings from this study could be used to understand these changes and inform intervention strategies to improve the healthcare relationship.
Effect of a High-Intensity Circuit Training Program on the Physical Fitness of Wildland Firefighters
Authors: Gutiérrez-Arroyo Jorge , García-Heras Fabio , Carballo-Leyenda Belén , Villa-Vicente José G. , Rodríguez-Medina Juan , Rodríguez-Marroyo Jose A.
Published: January 2023

Wildland firefighting implies high physical and psychological demands for the personnel involved. Therefore, good physical fitness can help increase the work efficiency of wildland firefighters (WFFs) and safeguard their health. High-intensity circuit training (HICT) could be a good alternative to improve the physical condition of WFFs since it stands out for its functionality and economy. Therefore, the objective of this study was to analyze the effects of HICT on the WFFs’ physical fitness. The study involved 9 WFFs (8 males and 1 female; 29.8 ± 2.8 years; 175.6 ± 6.7 cm) who completed a training program and 9 WFF candidates (8 males and 1 female; 24.7 ± 6.6 yr, 176.5 ± 7.0 cm) as a control group. WFFs performed an 8-week HICT program (two weekly training sessions). The training sessions lasted approximately 45 min and were performed at an intensity >80% of maximal heart rate and RPE values >7.5. At the beginning and the end of the intervention, subjects’ physical fitness (i.e., aerobic capacity, cardiorespiratory endurance, muscular resistance and explosive strength) was assessed through different tests. After completing the training program, WFFs had significantly increased (p < 0.05) the speed at which the ventilatory thresholds were determined (12.4 ± 13.9 and 5.7 ± 7.3% for the ventilatory and respiratory compensation thresholds, respectively) and also their abdominal (31.2 ± 17.2%), lumbar (34.1 ± 13.5%) and upper limb (13.3 ± 16.0%) strength. Moreover, improvements (p < 0.05) in the explosive strength of legs (7.1 ± 5.8%) and performance in a specific physical employment test (12.2 ± 6.1%) were observed. In conclusion, the results of this study show that an 8-week high-intensity circuit training program could be an effective and safe method to improve WFFs’ physical fitness and performance.
Spatiotemporal Evolution of Carbon Emissions According to Major Function-Oriented Zones: A Case Study of Guangdong Province, China
Authors: Zhu Jiang , Li Xiang , Huang Huiming , Yin Xiangdong , Yao Jiangchun , Liu Tao , Wu Jiexuan , Chen Zhangcheng
Published: January 2023

Studying the spatiotemporal evolution of carbon emissions from the perspective of major function-oriented zones (MFOZs) is crucial for making a carbon reduction policy. However, most previous research has ignored the spatial characteristics and MFOZ influence. Using statistical and spatial analysis tools, we explored the spatiotemporal characteristics of carbon emissions in Guangdong Province from 2001 to 2021. The following results were obtained: (1) Carbon emissions fluctuated from 2020 to 2021 because of COVID-19. (2) Over the last 20 years, the proportion of carbon emissions from urbanization development zones (UDZs) has gradually decreased, whereas those of the main agricultural production zones (MAPZs) and key ecological function zones (KEFZs) have increased. (3) Carbon emissions efficiency differed significantly among the three MFOZs. (4) Carbon emissions from coastal UDZs were increasingly apparent; however, the directional characteristics of MAPZ and KEFZ emissions were not remarkable. (5) Carbon transfer existed among the three kinds of MFOZs, resulting in the economy and carbon emissions being considerably misaligned across Guangdong Province. These results indicated that the MFOZ is noteworthy in revealing how carbon emissions evolved. Furthermore, spatiotemporal characteristics, especially spatial characteristics, can help formulate carbon reduction policies for realizing carbon peak and neutrality goals in Guangdong Province.
Big Data Management Algorithms, Deep Learning-Based Object Detection Technologies, and Geospatial Simulation and Sensor Fusion Tools in the Internet of Robotic Things
Authors: Andronie Mihai , Lăzăroiu George , Iatagan Mariana , Hurloiu Iulian , Ștefănescu Roxana , Dijmărescu Adrian , Dijmărescu Irina
Published: January 2023

The objective of this systematic review was to analyze the recently published literature on the Internet of Robotic Things (IoRT) and integrate the insights it articulates on big data management algorithms, deep learning-based object detection technologies, and geospatial simulation and sensor fusion tools. The research problems were whether computer vision techniques, geospatial data mining, simulation-based digital twins, and real-time monitoring technology optimize remote sensing robots. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were leveraged by a Shiny app to obtain the flow diagram comprising evidence-based collected and managed data (the search results and screening procedures). Throughout January and July 2022, a quantitative literature review of ProQuest, Scopus, and the Web of Science databases was performed, with search terms comprising “Internet of Robotic Things” + “big data management algorithms”, “deep learning-based object detection technologies”, and “geospatial simulation and sensor fusion tools”. As the analyzed research was published between 2017 and 2022, only 379 sources fulfilled the eligibility standards. A total of 105, chiefly empirical, sources have been selected after removing full-text papers that were out of scope, did not have sufficient details, or had limited rigor For screening and quality evaluation so as to attain sound outcomes and correlations, we deployed AMSTAR (Assessing the Methodological Quality of Systematic Reviews), AXIS (Appraisal tool for Cross-Sectional Studies), MMAT (Mixed Methods Appraisal Tool), and ROBIS (to assess bias risk in systematic reviews). Dimensions was leveraged as regards initial bibliometric mapping (data visualization) and VOSviewer was harnessed in terms of layout algorithms.
Landslide Susceptibility Assessment in the Japanese Archipelago Based on a Landslide Distribution Map
Authors: Kohno Masanori , Higuchi Yuki
Published: January 2023

Though danger prediction and countermeasures for landslides are important, it is fundamentally difficult to take preventive measures in all areas susceptible to dangerous landslides. Therefore, it is necessary to perform landslide susceptibility mapping, extract slopes with high landslide hazard/risk, and prioritize locations for conducting investigations and countermeasures. In this study, landslide susceptibility mapping along the whole slope of the Japanese archipelago was performed using the analytical hierarchy process (AHP) method, and geographic information system analysis was conducted to extract the slope that had the same level of hazard/risk as areas where landslides occurred in the past, based on the ancient landslide topography in the Japanese archipelago. The evaluation factors used were elevation, slope angle, slope type, flow accumulation, geology, and vegetation. The landslide susceptibility of the slope was evaluated using the score accumulation from the AHP method for these evaluation factors. Based on the landslide susceptibility level (I to V), a landslide susceptibility map was prepared, and landslide susceptibility assessment in the Japanese archipelago was identified. The obtained landslide susceptibility map showed good correspondence with the landslide distribution, and correlated well with past landslide occurrences. This suggests that our method can be applied to the extraction of unstable slopes, and is effective for prioritizing and implementing preventative measures.
CircAMOTL1 RNA and AMOTL1 Protein: Complex Functions of AMOTL1 Gene Products
Authors: Sadlak Joanna , Joshi Ila , Prószyński Tomasz J. , Kischel Anthony
Published: January 2023

The complexity of the cellular proteome facilitates the control of a wide range of cellular processes. Non-coding RNAs, including microRNAs and long non-coding RNAs, greatly contribute to the repertoire of tools used by cells to orchestrate various functions. Circular RNAs (circRNAs) constitute a specific class of non-coding RNAs that have recently emerged as a widely generated class of molecules produced from many eukaryotic genes that play essential roles in regulating cellular processes in health and disease. This review summarizes current knowledge about circRNAs and focuses on the functions of AMOTL1 circRNAs and AMOTL1 protein. Both products from the AMOTL1 gene have well-known functions in physiology, cancer, and other disorders. Using AMOTL1 as an example, we illustrate how focusing on both circRNAs and proteins produced from the same gene contributes to a better understanding of gene functions.
The Critical Impact of Sphingolipid Metabolism in Breast Cancer Progression and Drug Response
Authors: Corsetto Paola Antonia , Zava Stefania , Rizzo Angela Maria , Colombo Irma
Published: January 2023

Breast cancer is the second leading cause of cancer-related death in women in the world, and its management includes a combination of surgery, radiation therapy, chemotherapy, and immunotherapy, whose effectiveness depends largely, but not exclusively, on the molecular subtype (Luminal A, Luminal B, HER2+ and Triple Negative). All breast cancer subtypes are accompanied by peculiar and substantial changes in sphingolipid metabolism. Alterations in sphingolipid metabolite levels, such as ceramides, dihydroceramide, sphingosine, sphingosine-1-phosphate, and sphingomyelin, as well as in their biosynthetic and catabolic enzymatic pathways, have emerged as molecular mechanisms by which breast cancer cells grow, respond to or escape therapeutic interventions and could take on diagnostic and prognostic value. In this review, we summarize the current landscape around two main themes: 1. sphingolipid metabolites, enzymes and transport proteins that have been found dysregulated in human breast cancer cells and/or tissues; 2. sphingolipid-driven mechanisms that allow breast cancer cells to respond to or evade therapies. Having a complete picture of the impact of the sphingolipid metabolism in the development and progression of breast cancer may provide an effective means to improve and personalize treatments and reduce associated drug resistance.
Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells
Authors: Tominaga Kaoru , Sakashita Eiji , Kasashima Katsumi , Kuroiwa Kenji , Nagao Yasumitsu , Iwamori Naoki , Endo Hitoshi
Published: January 2023

Epigenetic regulation via epigenetic factors in collaboration with tissue-specific transcription factors is curtail for establishing functional organ systems during development. Brain development is tightly regulated by epigenetic factors, which are coordinately activated or inactivated during processes, and their dysregulation is linked to brain abnormalities and intellectual disability. However, the precise mechanism of epigenetic regulation in brain development and neurogenesis remains largely unknown. Here, we show that Tip60/KAT5 deletion in neural stem/progenitor cells (NSCs) in mice results in multiple abnormalities of brain development. Tip60-deficient embryonic brain led to microcephaly, and proliferating cells in the developing brain were reduced by Tip60 deficiency. In addition, neural differentiation and neuronal migration were severely affected in Tip60-deficient brains. Following neurogenesis in developing brains, gliogenesis started from the earlier stage of development in Tip60-deficient brains, indicating that Tip60 is involved in switching from neurogenesis to gliogenesis during brain development. It was also confirmed in vitro that poor neurosphere formation, proliferation defects, neural differentiation defects, and accelerated astrocytic differentiation in mutant NSCs are derived from Tip60-deficient embryonic brains. This study uncovers the critical role of Tip60 in brain development and NSC maintenance and function in vivo and in vitro.
Neurons, Nose, and Neurodegenerative Diseases: Olfactory Function and Cognitive Impairment
Authors: Fatuzzo Irene , Niccolini Giovanni Francesco , Zoccali Federica , Cavalcanti Luca , Bellizzi Mario Giuseppe , Riccardi Gabriele , de Vincentiis Marco , Fiore Marco , Petrella Carla , Minni Antonio , Barbato Christian
Published: January 2023

Olfactory capacity declines with aging, but increasing evidence shows that smell dysfunction is one of the early signs of prodromal neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The study of olfactory ability and its role in neurodegenerative diseases arouses much interest in the scientific community. In neurology, olfactory impairment is a potential early marker for the onset of neurodegenerative diseases, but the underlying mechanism is poorly understood. The loss of smell is considered a clinical sign of early-stage disease and a marker of the disease’s progression and cognitive impairment. Highlighting the importance of biological bases of smell and molecular pathways could be fundamental to improve neuroprotective and therapeutic strategies. We focused on the review articles and meta-analyses on olfactory and cognitive impairment. We depicted the neurobiology of olfaction and the most common olfactory tests in neurodegenerative diseases. In addition, we underlined the close relationship between the olfactory and cognitive deficit due to nasal neuroepithelium, which is a direct extension of the CNS in communication with the external environment. Neurons, Nose, and Neurodegenerative diseases highlights the role of olfactory dysfunction as a clinical marker for early stages of neurodegenerative diseases when it is associated with molecular, clinical, and neuropathological correlations.
RNA Extraction from Cartilage: Issues, Methods, Tips
Authors: Pagani Stefania , Maglio Melania , Sicuro Laura , Fini Milena , Giavaresi Gianluca , Brogini Silvia
Published: January 2023

The increase in degenerative diseases involving articular cartilage has pushed research to focus on their pathogenesis and treatment, exploiting increasingly complex techniques. Gene expression analyses from tissue are representative of the in vivo situation, but the protocols to be applied to obtain a reliable analysis are not completely cleared through customs. Thus, RNA extraction from fresh samples and specifically from musculoskeletal tissue such as cartilage is still a challenging issue. The aim of the review is to provide an overview of the techniques described in the literature for RNA extraction, highlighting limits and possibilities. The research retrieved 65 papers suitable for the purposes. The results highlighted the great difficulty in comparing the different studies, both for the sources of tissue used and for the techniques employed, as well as the details about protocols. Few papers compared different RNA extraction methods or homogenization techniques; the case study reported by authors about RNA extraction from sheep cartilage has not found an analog in the literature, confirming the existence of a relevant blank on studies about RNA extraction from cartilage tissue. However, the state of the art depicted can be used as a starting point to improve and expand studies on this topic.
Insight into the Varying Reactivity of Different Catalysts for CO2 Cycloaddition into Styrene Oxide: An Experimental and DFT Study
Authors: Sebaaly Angelo Pio , Dias Hugo , Christ Lorraine , Merzoud Lynda , Chermette Henry , Hoffmann Guillaume , Morell Christophe
Published: January 2023

The cycloaddition of CO2 into epoxides to form cyclic carbonates is a highly sought-after reaction for its potential to both reduce and use CO2, which is a greenhouse gas. In this paper, we present experimental and theoretical studies and a mechanistic approach for three catalytic systems. First, as Lewis base catalysts, imidazole and its derivatives, then as a Lewis acid catalyst, ZnI2 alone, and after that, the combined system of ZnI2 and imidazole. In the former, we aimed to discover the reasons for the varied reactivities of five Lewis base catalysts. Furthermore, we succeeded in reproducing the experimental results and trends using DFT. To add, we emphasized the importance of non-covalent interactions and their role in reactivity. In our case, the presence of a hydrogen bond was a key factor in decreasing the reactivity of some catalysts, thus leading to lower conversion rates. Finally, mechanistically understanding this 100% atom economy reaction can aid experimental chemists in designing better and more efficient catalytic systems.
Immunopharmacological Activities of Luteolin in Chronic Diseases
Authors: Huang Lei , Kim Mi-Yeon , Cho Jae Youl
Published: January 2023

Flavonoids have been shown to have anti-oxidative effects, as well as other health benefits (e.g., anti-inflammatory and anti-tumor functions). Luteolin (3′, 4′, 5,7-tetrahydroxyflavone) is a flavonoid found in vegetables, fruits, flowers, and herbs, including celery, broccoli, green pepper, navel oranges, dandelion, peppermint, and rosemary. Luteolin has multiple useful effects, especially in regulating inflammation-related symptoms and diseases. In this paper, we summarize the studies about the immunopharmacological activity of luteolin on anti-inflammatory, anti-cardiovascular, anti-cancerous, and anti-neurodegenerative diseases published since 2018 and available in PubMed or Google Scholar. In this review, we also introduce some additional formulations of luteolin to improve its solubility and bioavailability.