bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Sleep Stage on the Determination of Positional Dependency in Patients With Obstructive Sleep Apnea
Authors: Ryu Somi , Kim Seung Chan , Kim Rock Bum , Lee Byeong Min , Park Sang-Wook , Jeon Yung-Jin , Joo Yeon-Hee , Cho Hyun-Jin , Kim Sang-Wook
Published: June 2024

Objectives. The supine sleep position and the rapid eye movement (REM) stage are widely recognized to exacerbate the severity of obstructive sleep apnea (OSA). Position-dependent OSA is generally characterized by an apnea-hypopnea index (AHI) that is at least twice as high in the supine position compared to other sleep positions. However, this condition can be misdiagnosed if a particular sleep stage—REM or non-REM (NREM)—predominates in a specific position. We explored the impact of the sleep stage on positional dependency in OSA.Methods. Polysomnographic data were retrospectively analyzed from 111 patients with OSA aged 18 years or older, all of whom had an AHI exceeding five events per hour and slept in both supine and non-supine positions for at least 5% of the total sleep time. The overall ratio of non-supine AHI to supine AHI (NS/S-AHI ratio) was compared between total, REM, and NREM sleep. Additionally, a weighted NS/S-AHI ratio, reflecting the proportion of time spent in each sleep stage, was calculated and compared to the original ratio.Results. The mean NS/S-AHI ratio was consistent between the entire sleep period and the specific sleep stages. However, the NS/S-AHI ratios for individual patients displayed poor agreement between total sleep and the specific stages. Additionally, the weighted NS/S-AHI ratio displayed poor agreement with the original NS/S-AHI ratio, primarily due to discrepancies in patients with mild to moderate OSA.Conclusion. The weighted NS/S-AHI ratio may help precisely assess positional dependency.
Challenging the Concept of Statistical Fragility: Is There Any Value Added?
Authors: Hao Kevin A. , Vasilopoulos Terrie , Wright Jonathan O. , Schoch Bradley S.
Published: June 2024

Today, well-designed randomized clinical trials (RCTs) are considered the pinnacle of clinical research, and they inform many practices in orthopaedics. When designing these studies, researchers conduct a power analysis, which allows researchers to strike a balance between (1) enrolling enough patients to detect a clinically important treatment effect (i.e., researchers can be confident that the effect is unlikely due to chance) and (2) cost, time, and risk to patients, which come with enrolling an excessive number of patients. Because researchers will have a desire to conduct resource-efficient RCTs and protect patients from harm, many studies report a p value that is close to the threshold for significance. The concept of the fragility index (FI) was introduced as a simple way to interpret RCT findings, but it does not account for RCT design. The adoption of the FI conflicts with researchers’ goals of designing efficient RCTs that conserve resources and limit ineffective or harmful treatments to patients. The use of the FI may reflect many clinicians’ lack of familiarity with interpreting p values beyond “significant” or “nonsignificant.” Instead of inventing new metrics to convey the same information provided by the p value, greater emphasis should be placed on educating clinicians on how to interpret p values and, more broadly, statistics, when reading scientific studies.
Spatial variations in vegetation fires and emissions in South and Southeast Asia during COVID-19 and pre-pandemic
Authors: Vadrevu Krishna , Eaturu Aditya , Casadaban Emily , Lasko Kristofer , Schroeder Wilfrid , Biswas Sumalika , Giglio Louis , Justice Chris
Published: June 2024

Vegetation fires are common in South/Southeast Asian (SA/SEA) countries. However, few studies focused on vegetation fires and the changes during COVID compared to pre‑pandemic. This study fills an information gap and reports total fire incidences, total burnt area, type of vegetation burnt, and total particulate matter emission variations. Results from the short‑term 2020‑COVID versus 2019‑non‑COVID year showed a decline in fire counts varying from -2.88 to 79.43%. The exceptions in South Asia include Afghanistan and Sri Lanka, and Cambodia and Myanmar in Southeast Asia. The burnt area decline for 2020 compared to 2019 varied from -0.8% to 92% for South/Southeast Asian countries, with most burning in agricultural landscapes than forests. Several patches in S/SEA showed a decrease in fires for the 2020 pandemic year compared to long term 2012–2020 pre‑pandemic record, with Z scores greater or less than two denoting statistical significance. However, on a country scale, the results were not statistically significant in both S/SEA, with Z scores ranging from -0.24 to -1, although most countries experienced a decrease in fire counts. The study highlights variations in fires and emissions useful for fire management and mitigation.
Integrated Insights into Lithofacies, Fracture Networks, and Reservoir Productivity in Basement Reservoirs: A Comprehensive Case Study from the Cauvery Basin, India, Using Well Logs, Petrographic Studies, and Production Logs
Authors: Mogali Phaneendra , Desai Bhawanisingh G.
Published: June 2024

The architecture and heterogeneity of basement rocks can play a crucial role in reservoir evaluation and hydrocarbon exploration. This study focuses on the comprehensive characterization of basement reservoir heterogeneities and fracture networks in the Cauvery Basin using a combination of petrophysical and geochemical analyses. The intricate interplay of lithological variations and chemical alteration processes in basement rocks significantly influences their complex nature.

In this study, openhole log data acquired in the basement section from wells within the Cauvery Basin were analyzed. These log data were correlated with core studies to understand the lithofacies heterogeneities present within the basement reservoir. Furthermore, fracture data obtained from resistivity image log data were examined to understand the distribution and properties of fractures in relation to lithofacies heterogeneities. Notably, a higher fracture density was observed in the mafic-rich sections compared to the felsic-rich sections. The integration of resistivity image log data with lithofacies contributed to the understanding of the reservoir architecture. Additionally, elemental spectroscopy logging facilitated geochemical analysis, providing measurements of the elemental composition of basement, which were incorporated into the study. Production logging (PL) was performed in the study wells to ascertain the production from the basement reservoir. This analytical approach augmented the characterization of the basement reservoir and contributed to a holistic understanding of its properties.

This study emphasizes the role of conducting a thorough analysis of petrophysical log responses in conjunction with detailed core studies to characterize basement reservoirs. The study successfully differentiated two distinct lithofacies units within the Cauvery Basin’s basement reservoirs: mafic-mineral-dominated and felsic-mineral-dominated and their impact on reservoir heterogeneities. Production log data validated hydrocarbon contributions primarily from felsic rocks, underscoring the importance of lithological variations.
Youth migration during war: Triggers of positive aspirations and preservation of human resources in Ukraine
Authors: Vasyltsiv Taras , Lupak Ruslan , Mulska Olha , Levytska Olha , Baranyak Ihor
Published: June 2024

Russia’s full-scale invasion of Ukraine has become an existential challenge and a trigger of the migration crisis. The study aims to identify migration intentions of youth and factors for the preservation of the young population in Ukraine (a case study of university youth). The study conducts a sociological survey using a Google Forms questionnaire. The sample was formed by the method of three-stage selection: (1) quotas for the share of undergraduate and graduate students; (2) the higher education institutions in Ukraine were selected by the criterion of the number of students and specialties; and (3) field of knowledge. The sample size is calculated based on the resampling method and included 2,200 people from all regions in Ukraine (except Donetsk, Luhansk, Zaporizhzhia, and Dnipropetrovsk oblasts). The study reveals that 10% of students plan to go abroad in the near future before graduation, 30% plan to stay in Ukraine only if the socio-economic situation improves after the end of the war, and 28.3% plan to migrate after graduation. The reasons for positive migration aspirations among students are socio-economic and security issues (14.9% can find a job abroad in the short term, 11.1% see the lack of further prospects in Ukraine even after the end of the war). Monitoring of youth migration processes across two vectors – current volumes and potential aspirations – can serve as an information and analytical basis for the development of a new vision of the country’s migration security strategy to preserve human resources in Ukraine.
Understanding and Implementation of Islamic Law: Study of the Unrecorded Polygyny Phenomenon in Karawang Regency
Authors: Waluyo Kasja Eki , Syafe’i Rachmat , Aen I Nurol , Saebani Beni Ahmad
Published: June 2024

The practice of polygamy is still a polemic to this day, with pros and cons both from human rights activists and from polygamy practitioners themselves. This research aims to examine the phenomenon of polygyny in Karawang Regency from the perspective of Islamic law and laws for justice; the social conditions that occur in Karawang further impact family welfare, such as household harmony, economic conditions, early marriage, and even polygamy. Polygamy has increased in Karawang in the form of polygyny. A lack of understanding about fairness in polygynous marriages in Karawang society supports the problems that arise from the occurrence of polygyny. The approach used in this research is an empirical juridical approach, or field research, examining applicable legal provisions and what happens in society. The results of the research show that the understanding of husbands and wives who practice polygyny in Karawang regarding Law No. 1 of 1974 regarding marriage varies, and some need help understanding the law, especially those relating to polygynous marriages. Some need help understanding law no. 1 of 1974, limited public understanding of Law no. 1 1974 concerning marriage is due to a lack of public interest. Also, because socialization regarding this law is uneven, especially regarding polygynous marriages, the public is more interested in using Islamic law.
The Typologies of Islamic Thought: Mapping The Contemporary Intellectual Movements in Indonesia
Authors: Amin Faizal
Published: June 2024

The continuity and change of reformation ideas in the history of the Islamic intellectual movement necessitate a systematic categorization. This article endeavors to present a fresh framework for classifying Islamic thought, drawing inspiration from Fazlur Rahman’s categories of revivalist, classical modernist, neo-revivalist, and neo-modernist. More specifically, this article  examines a reclassification of Islamic thought and elaborates on its implications for the contemporary historical narrative of the Islamic intellectual movement within the Indonesian context. By undertaking a comprehensive literature review and employing a descriptive methodology for data collection and analysis, this article found out eight categories or typologies characterizing contemporary Islamic intellectual movements in Indonesia: (1) the revivalist movement, (2) the classical modernist movement, (3) the neo-revivalist movement, (4) the neo-modernist movement, (5) the traditionalist movement, (6) the neo-traditionalist movement, (7) the post-modernist movement, and (8) the post-traditionalist movement. These typologies commence with the emergence of classical modernism juxtaposed against classical traditionalism as the turning point of the dialectical progression of Indonesian Islamic intellectualism. Each typology has undergone a transformative process and metamorphosis within a dynamic scientific dialectic.
Phytoconstituents-Based Nanotherapeutic Approach for the Effective Management of Joint Inflammatory Condition: Arthritis
Authors: Kharbanda Jyotsna , Mazumder Rupa , Bhardwaj Snigdha , Mazumder Avijit , Mishra Rakhi , Mishra Rashmi , Kumar Bimlesh
Published: June 2024

:

Arthritis, a prevalent inflammatory joint condition, presents challenges for effective
therapeutic interventions, with conventional treatments often limited in efficacy and associated
with adverse effects. Recent years have witnessed a growing interest in exploring natural compounds,
particularly phytoconstituents, renowned for their anti-inflammatory and joint-protective
properties. This review aims to illuminate the potential of employing nanotherapeutic approaches
with phytoconstituents for enhanced arthritis management. The integration of nanotechnology
with phytoconstituents emerges as a promising strategy, addressing limitations in traditional arthritis
treatments. Nanocarriers like liposomes and nanoparticles provide a platform for targeted drug
delivery, improving the bioavailability of phytoconstituents. Furthermore, the combined effects of
phytoconstituents can be leveraged to target multiple pathways in arthritis pathogenesis, including
inflammation, oxidative stress, and cartilage degradation. Key phytoconstituents, such as curcumin,
resveratrol, and quercetin, exhibit anti-inflammatory and immunomodulatory properties. Nevertheless,
their therapeutic potential is often impeded by challenges like poor solubility, stability,
and bioavailability. Nanocarriers offer solutions by enhancing pharmacokinetics and enabling sustained
release, thereby boosting overall therapeutic efficacy. The review explores the mechanisms
underlying the anti-arthritic effects of phytoconstituents and their nanoformulations, including the
modulation of pro-inflammatory cytokines, inhibition of matrix metalloproteinases, and reduction
of oxidative stress. In summary, the integration of phytoconstituents with nanotechnology presents
a promising avenue for developing targeted and effective arthritis therapies. This comprehensive
review serves as a valuable resource for researchers, clinicians, and pharmaceutical developers
seeking innovative approaches to address the intricate challenges associated with arthritis management.
Harvesting Health: Phytochemicals in Cognitive Impairment Therapy
Authors: Jain Sanidhya , Mazumder Avijit , Das Saumya , Tyagi Pankaj Kumar , Chaitanya MVNL
Published: June 2024

Mild Cognitive Impairment (MCI) is swiftly emerging as a prevalent clinical concern
within the elderly demographic. Willoughby spearheaded the pioneering investigation into the
evolution of memory decline spanning from the age of 20 to 70. Employing a computerized
substitution examination, he pinpointed a zenith in memory prowess at the age of 22, signifying
the shift from infancy, succeeded by a gradual decline in later years in 1929. Cognitive impairment
impacts various facets, encompassing cognition, memory, perceptual acuity, and linguistic
proficiency. Compelling evidence indicates that genetic, dietary, and metabolic factors influence
the trajectory of cognitive decline in this patient cohort. In addition to the widely recognized
influence of the Mediterranean diet on cognitive function, numerous studies have delved
into the potential impact of diverse phytochemicals on cognitive deterioration. Many of these
compounds are renowned for their inflammation reducer or free-radical scavenger properties,
coupled with their commendable acceptability and defense profiles. Phytochemicals sourced
from medicinal plants play an essential role in upholding the intricate chemical equilibrium of
the brain by modulating receptors linked to crucial inhibitory neurotransmitters. Across the annals
of historical medicinal traditions, a multitude of plants have been cataloged for their efficacy
in mitigating cognitive disorders. This study presents a concise examination of distinct medicinal
herbs, highlighting their neuroprotective phytochemical components such as fatty acids,
phenols, alkaloids, flavonoids, saponins, terpenes, and beyond. The principal objective of this
inquiry is to meticulously inspect and provide discernment into the extant evidence concerning
phytochemicals exhibiting clinically demonstrable effects on cognitive decline
Mechanistic Review on the Role of Gut Microbiota in the Pathology of
Cardiovascular Diseases
Authors: Usman Iqra , Anwar Aamir , Shukla Shivang , Pathak Priya
Published: June 2024

Cardiovascular diseases (CVDs), which stand as the primary contributors to illness and
death on a global scale, include vital risk factors like hyperlipidemia, hypertension, diabetes, and
smoking, to name a few. However, conventional cardiovascular risk factors offer only partial insight
into the complexity of CVDs. Lately, a growing body of research has illuminated that the
gut microbiome and its by-products are also of paramount importance in the initiation and progression
of CVDs. The gastrointestinal tract houses trillions of microorganisms, commonly known as
gut microbiota, that metabolize nutrients, yielding substances like trimethylamine-N-oxide (TMAO),
bile acids (BAs), short-chain fatty acids (SCFAs), indoxyl sulfate (IS), and so on. Strategies
aimed at addressing these microbes and their correlated biological pathways have shown
promise in the management and diagnosis of CVDs. This review offers a comprehensive examination
of how the gut microbiota contributes to the pathogenesis of CVDs, particularly atherosclerosis,
hypertension, heart failure (HF), and atrial fibrillation (AF), explores potential underlying
mechanisms, and highlights emerging therapeutic prospects in this dynamic domain.
AUTHENTICITY AND UNIQUENESS OF ASINAN BOGOR AS A DISTINCTIVE CULINARY DELIGHT OF BOGOR CITY
Authors: Putri Ardaneswara , Ramdhani Rafy , Rosalia Melva , Arraniri Fahma Faradisa , Kurnia Insan , Rahayu Kania Sofiantina
Published: June 2024

Asinan bogor, commonly known as Bogor salty pickles, represents a traditional delicacy of Bogor, Indonesia, consisting of processed vegetables and fruits consumed raw alongside various additional ingredients.  This research aims to delve into the uniqueness of asinan bogor.  The study was conducted through surveys interviews, and questionnaires administered to 40 asinan Bogor sellers in Bogor City.  Sellers unanimously recognize asinan bogor as a Bogor traditional dish.  Sellers exhibit the highest level of knowledge concerning raw materials, with history being their least familiar aspect.  While no main ingredients are obligatory, specific components hold priority, such as bean sprouts for vegetables pickled; and mango, water guava, and jicama for fruits pickled.  Mandatory seasoning ingredients include ground red chili, salt, and water.  The composition of asinan ingredients varies based on consumer preferences.  Antanan is rarely utilized as a primary ingredient, whereas salted mustard green epitomizes Chinese cuisine.  Currently, the serving of asinan bogor is predominantly in plastic packaging, deviating from on-site consumption, particularly for souvenir packaging.  The paramount uniqueness of the asinan bogor lies in the gravy.
The impact of teacher training on the delivery of quality education: A study of schools in Mogadishu, Somalia
Authors:   Faculty of Education, SIMAD University, Mogadishu, Somalia, Idris Mohamed Osman Abdi , Mohamed Mohamed Jama ,   Faculty of Education, SIMAD University, Mogadishu, Somalia, Hussein Abdikadir Abdullahi ,   Faculty of Education, SIMAD University, Mogadishu, Somalia, Mohamed Mohamedamin Omar ,   Faculty of Education, SIMAD University, Mogadishu, Somalia, Omar Abukar Mukhtar ,   Faculty of Education, SIMAD University, Mogadishu, Somalia
Published: June 2024

Today, improving the quality of education is central to Africa’s strategic goal of catching up with industrialized nations. This study focused on the effects of pre-service and in-service teacher training on the quality of education in private and public schools in the Mogadishu Benadir region of Somalia. The research used a quantitative approach, collecting data through a questionnaire distributed to a significant sample of individuals. Non-probability sampling was utilized, targeting teachers and school principals who were readily accessible and selected purposefully. The study involved 145 participants, including both principals and teachers from private and public schools in the region. Factor analysis was used to examine the relationship between pre-service and in-service teacher training and the provision of quality education. The findings indicated that both pre-service and in-service training are crucial investments for enhancing educational quality, with correlation coefficients of 0.648 and 0.660, respectively, showing a positive relationship with the quality of education. The study demonstrates the significant positive impact of teacher training on educational quality and suggests further research is needed to explore how this training aligns with educational curriculum and standards.
Os stilettos de Patty
Authors: Carpani Stefano
Published: June 2024

O trabalho tem como objetivo apresentar o caso clínico de Patty cuja imaturidade está relacionada com o fato de ainda não ter nascido, vivendo em estado embrionário, não separada de sua mãe e subjugada ao complexo feminino, revelando um vínculo secreto que é conscientemente expresso no uso de esmalte e salto alto, e inconscientemente expresso através do sonho inicial, com Isis, símbolo da integração que permite a libertação. Para isso evoca as lições dos sociólogos Beck e Bauman, da psicanalista junguiana Kulkarni e outros. Retoma a teoria junguiana sobre a homossexualidade, a natureza não patológica da homoafetividade, registra que nada é mais obstrutivo ao desenvolvimento do que a persistência em um estado inconsciente. Propõe que a ligação entre a psique e o impacto influenciam-se reciprocamente, explicita as várias visões de individuação, enfatiza o quesito da libertação no processo de individuação.
Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities
Authors: Mega Obukohwo Oyovwi , Abosede Oreoluwa Oyelere , Comfort Odewale O. , Opeyemi Olanike Afolabi
Published: June 2024

Infertility affects millions globally, with 10-15% of couples experiencing unexplained cases. Despite advancements in medicine, the cause remains unknown, causing emotional distress. Recent research suggests a genetic basis for this issue. This review aims to provide a better understanding of the underlying genetic factors contributing to unexplained infertility and potentially identify genetic markers that could aid in the diagnosis and treatment of this condition. A literature review was conducted to understand the genetic basis of unexplained infertility. Relevant articles from databases like PubMed and Google Scholar were analyzed, covering topics like genetics, chromosomal abnormalities, genetic markers, and fertility, resulting in 50 articles. The literature review revealed that there is a strong correlation between unexplained infertility and chromosomal abnormalities. Several studies have reported an increased rate of chromosomal abnormalities in couples with unexplained infertility compared to those with normal fertility. Around 10% of couples with unexplained infertility had chromosomal abnormalities, with the most common being translocations. A higher rate of chromosomal abnormalities in couples with unexplained infertility who had a history of recurrent miscarriages. The review reveals a significant genetic component to unexplained infertility, with chromosomal abnormalities in affected couples indicating underlying genetic factors. Further research is needed to identify specific genetic markers for diagnosis and treatment, potentially leading to personalized treatment options. Genetic counseling and testing should be considered for couples with recurrent miscarriages to identify potential abnormalities and provide appropriate support.
A Patient-Driven Mobile Health Innovation in Cystic Fibrosis Care: Comparative Cross-Case Study
Authors: Mazzocato Pamela , Luckhaus Jamie Linnea , Malmqvist Castillo Moa , Burnett Johan , Hager Andreas , Oates Gabriela , Wannheden Carolina , Savage Carl
Published: June 2024

Background

Patient-driven innovation in health care is an emerging phenomenon with benefits for patients with chronic conditions, such as cystic fibrosis (CF). However, previous research has not examined what may facilitate or hinder the implementation of such innovations from the provider perspective.

Objective

The aim of this study was to explain variations in the adoption of a patient-driven innovation among CF clinics.

Methods

A comparative multiple-case study was conducted on the adoption of a patient-controlled app to support self-management and collaboration with health care professionals (HCPs). Data collection and analysis were guided by the nonadoption, abandonment, spread, scale-up, and sustainability and complexity assessment tool (NASSS-CAT) framework. Data included user activity levels of patients and qualitative interviews with staff at 9 clinics (n=8, 88.9%, in Sweden; n=1, 11.1%, in the United States). We calculated the maximum and mean percentage of active users at each clinic and performed statistical process control (SPC) analysis to explore how the user activity level changed over time. Qualitative data were subjected to content analysis and complexity analysis and used to generate process maps. All data were then triangulated in a cross-case analysis.

Results

We found no evidence of nonadoption or clear abandonment of the app. Distinct patterns of innovation adoption were discernable based on the maximum end-user activity for each clinic, which we labeled as low (16%-23%), middle (25%-47%), or high (58%-95%) adoption. SPC charts illustrated that the introduction of new app features and research-related activity had a positive influence on user activity levels. Variation in adoption was associated with providers’ perceptions of care process complexity. A higher perceived complexity of the value proposition, adopter system, and organization was associated with lower adoption. In clinics that adopted the innovation early or those that relied on champions, user activity tended to plateau or decline, suggesting a negative impact on sustainability.

Conclusions

For patient-driven innovations to be adopted and sustained in health care, understanding patient-provider interdependency and providers’ perspectives on what generates value is essential.
Influence of Model Evolution and System Roles on ChatGPT’s Performance in Chinese Medical Licensing Exams: Comparative Study
Authors: Ming Shuai , Guo Qingge , Cheng Wenjun , Lei Bo
Published: June 2024

Background

With the increasing application of large language models like ChatGPT in various industries, its potential in the medical domain, especially in standardized examinations, has become a focal point of research.

Objective

The aim of this study is to assess the clinical performance of ChatGPT, focusing on its accuracy and reliability in the Chinese National Medical Licensing Examination (CNMLE).

Methods

The CNMLE 2022 question set, consisting of 500 single-answer multiple choices questions, were reclassified into 15 medical subspecialties. Each question was tested 8 to 12 times in Chinese on the OpenAI platform from April 24 to May 15, 2023. Three key factors were considered: the version of GPT-3.5 and 4.0, the prompt’s designation of system roles tailored to medical subspecialties, and repetition for coherence. A passing accuracy threshold was established as 60%. The χ2 tests and κ values were employed to evaluate the model’s accuracy and consistency.

Results

GPT-4.0 achieved a passing accuracy of 72.7%, which was significantly higher than that of GPT-3.5 (54%; P<.001). The variability rate of repeated responses from GPT-4.0 was lower than that of GPT-3.5 (9% vs 19.5%; P<.001). However, both models showed relatively good response coherence, with κ values of 0.778 and 0.610, respectively. System roles numerically increased accuracy for both GPT-4.0 (0.3%‐3.7%) and GPT-3.5 (1.3%‐4.5%), and reduced variability by 1.7% and 1.8%, respectively (P>.05). In subgroup analysis, ChatGPT achieved comparable accuracy among different question types (P>.05). GPT-4.0 surpassed the accuracy threshold in 14 of 15 subspecialties, while GPT-3.5 did so in 7 of 15 on the first response.

Conclusions

GPT-4.0 passed the CNMLE and outperformed GPT-3.5 in key areas such as accuracy, consistency, and medical subspecialty expertise. Adding a system role insignificantly enhanced the model’s reliability and answer coherence. GPT-4.0 showed promising potential in medical education and clinical practice, meriting further study.
Digital Gamification Tool (Let’s Control Flu) to Increase Vaccination Coverage Rates: Proposal for Algorithm Development
Authors: Lopes Henrique , Baptista-Leite Ricardo , Hermenegildo Catarina , Atun Rifat
Published: June 2024

Background

Influenza represents a critical public health challenge, disproportionately affecting at-risk populations, including older adults and those with chronic conditions, often compounded by socioeconomic factors. Innovative strategies, such as gamification, are essential for augmenting risk communication and community engagement efforts to address this threat.

Objective

This study aims to introduce the “Let’s Control Flu” (LCF) tool, a gamified, interactive platform aimed at simulating the impact of various public health policies (PHPs) on influenza vaccination coverage rates and health outcomes. The tool aligns with the World Health Organization’s goal of achieving a 75% influenza vaccination rate by 2030, facilitating strategic decision-making to enhance vaccination uptake.

Methods

The LCF tool integrates a selection of 13 PHPs from an initial set proposed in another study, targeting specific population groups to evaluate 7 key health outcomes. A prioritization mechanism accounts for societal resistance and the synergistic effects of PHPs, projecting the potential policy impacts from 2022 to 2031. This methodology enables users to assess how PHPs could influence public health strategies within distinct target groups.

Results

The LCF project began in February 2021 and is scheduled to end in December 2024. The model creation phase and its application to the pilot country, Sweden, took place between May 2021 and May 2023, with subsequent application to other European countries. The pilot phase demonstrated the tool’s potential, indicating a promising increase in the national influenza vaccination coverage rate, with uniform improvements across all targeted demographic groups. These initial findings highlight the tool’s capacity to model the effects of PHPs on improving vaccination rates and mitigating the health impact of influenza.

Conclusions

By incorporating gamification into the analysis of PHPs, the LCF tool offers an innovative and accessible approach to supporting health decision makers and patient advocacy groups. It enhances the comprehension of policy impacts, promoting more effective influenza prevention and control strategies. This paper underscores the critical need for adaptable and engaging tools in PHP planning and implementation.

International Registered Report Identifier (IRRID)

RR1-10.2196/55613
Measuring adult health and well-being outcomes associated with nature contact in parks and other forms of protected areas: a scoping review protocol (Preprint)
Authors: Bueddelfeld Jill , Reining Catherine E. , Lavallee Loraine , Brady Ryan , Groulx Mark W. , Lemieux Christopher James
Published: June 2024

BACKGROUND

Growing evidence shows various health and well-being benefits from nature contact in parks and other forms of protected areas. Methods to measure these outcomes lack systematic identification, critical appraisal, and synthesis.

OBJECTIVE

This scoping protocol details the methodology for a scoping review of the instruments that measure health and well-being linked to nature contact in protected areas, including their psychometric properties.

METHODS

A multidisciplinary team will conduct the review following PRISMA-ScR guidelines. Eight databases will be searched for peer-reviewed literature measuring the mental health and well-being outcomes associated with direct nature contact in protected areas among adults over 18 years of age. All retrieved sources will be screened using clearly identified inclusion/exclusion criteria. Psychometric properties of instruments used in included studies will be analyzed.

RESULTS

The scoping review will provide an organized summary of quantitative and qualitative instruments for measuring mental health and well-being outcomes, offering a starting point from which to critically examine the validity and consistency of such methods, helping researchers choose the best tool to assess outcomes.

CONCLUSIONS

Findings will aid in identifying the strengths and weaknesses of current measurement approaches to mental health and well-being outcomes of nature contact and may be used to guide future research on this topic.

CLINICALTRIAL

n/a
¿El agua de lluvia sin tratar es apta para su consumo?
Authors: García-Martínez Rocío , Calvo-Ramos Daniela , Muñoz-Torres Carolina , Carrillo-Chávez Alejandro , Hernández-Solís José , López-Carrasco Moisés
Published: June 2024

La escasez de agua amenaza el desarrollo la calidad de vida y la salud de los habitantes del mundo. El fenómeno de cambio climático ha acelerado exponencialmente el problema de sequias prolongadas, periodos de lluvia más cortos o lluvias intensas. La necesidad de captar la lluvia y utilizarla para su consumo, aumenta la presión sobre los países para que implementen prácticas más sostenibles e innovadoras. El objetivo general de este trabajo consistió en estudiar la composición química de agua de lluvia colectada durante el periodo 2015-2019 en el Observatorio Atmosférico de la UNAM (Ciudad Universitaria UNAM, Ciudad de México) y en el Observatorio Atmosférico Altzomoni (Parque Nacional Izta-Popo, Estado de México), pertenecientes a la Red Universitaria de Observatorios Atmosféricos (RUOA) del Instituto de Ciencias de la Atmósfera y Cambio Climático. Se obtuvo el factor de enriquecimiento (FE) utilizando, como valor de referencia análisis químicos de relación metal/Al y ión/Ca, obtenidos a partir de la concentración promedio ponderada de los metales analizados. Los FE altos sugirieron que, en general, los metales tienen un origen antropogénico ligado al cambio de uso de suelo y a la deforestación indiscriminada de sitios boscosos adyacentes a los sitios de estudio. Las concentraciones de Al, Cd, Fe, Pb y V fueron consistentes con una contribución antropogénica importante, debido probablemente al transporte desde diferentes ciudades del país, y a la contribución intrínseca de cada sitio de muestreo. El estudio de la persistencia, la presencia y la permanencia de metales pesados en agua de lluvia es necesario para promover proyectos actuales y futuros sobre su tratamiento y uso.
Recurso didáctico sobre química prebiótica: herramientas prácticas para comprender el origen de la vida
Authors: Valderrama-Méndez Ana Elisa , Castillo-Alcalá Luan Xanath , Villafañe-Barajas Saúl Alberto
Published: June 2024

El origen de la vida sigue siendo un enigma a pesar de los grandes avances científicos en las últimas décadas en las áreas de investigación de química prebiótica, astrobiología, geología espacial, biología molecular, entre muchas otras. En este trabajo, se explora cómo la química prebiótica, a través del estudio de la interacción entre minerales y moléculas orgánicas, ofrece pistas sobre los procesos que podrían haber conducido al surgimiento de la vida. Se propone un recurso didáctico que aborda los pasos interconectados que precedieron al surgimiento de las primeras formas de vida, desde la síntesis hasta la adquisición de propiedades emergentes en polímeros orgánicos. Este material educativo busca facilitar la comprensión del origen de la vida a través de una presentación accesible y clara de conceptos complejos, fomentando el aprendizaje activo y la reflexión sobre los procesos fundamentales involucrados.
Manejo endodóntico conservador en paciente con carcinoma metastásico. Revisión y reporte de caso
Authors: Mendiburu-Zavala Celia Elena del Perpetuo Socorro , Baeza-Denis Pamela , Carrillo-Mendiburu Josué , Peñaloza-Cuevas Ricardo
Published: June 2024

Introducción: el carcinoma es definido como una neoplasia maligna que se forma a partir del tejido epitelial, de etiología desconocida y multifactorial, relacionada con los hábitos de consumo de tabaco y alcohol; de rápido crecimiento, destrucción tisular local y capacidad para hacer metástasis. Objetivo: presentar el manejo endodóntico conservador en un paciente con carcinoma metastásico. Presentación del caso:  paciente masculino de 69 años, maya-hablante que acudió para valoración y tratamiento de los dientes 32 (con corona fenestrada) y 33, ambos sintomáticos. Durante la anamnesis refirió haber sido fumador y alcohólico, estar bajo tratamiento analgésico por dolor de masa indurada en la cadena ganglionar cervical izquierda, otitis media crónica y otorrea crónica, sin dolor ni fiebre, de un año de evolución. A la inspección clínica extraoral, se palpó la región ganglionar cervical izquierda agrandada e indurada, extendiéndose hasta el área submandibular y preauricular. Manifestó odinofagia leve y disfagia. Se diagnosticó periodontitis apical crónica (32) y necrosis pulpar parcial aséptica (33). Se realizó tratamiento de ambos dientes sin anestesia, aislamiento atraumático, apertura, tope apical, técnica de instrumentación StepBack, irrigación del conducto con hipoclorito de sodio (NaClO) al 5% para desinfección y conformación, secado y colocación de hidróxido de calcio (Ca(OH)₂), y sellado con resina. No se realizó obturación con gutapercha. Posterior al tratamiento endodóntico se realizó la interconsulta con oncología, donde se realizó biopsia del nódulo cervical izquierdo por aspiración con aguja fina, y se diagnosticó metástasis de carcinoma poco diferenciado con extensa necrosis. Se localizó tumor primario: carcinoma en laringe, por medio de ultrasonido con contraste. Conclusiones: El manejo fue conservador, por sospecha de la condición neoplásica que el paciente presentaba.
Grafoplastia y dactilopintura: revisión y planificación para la apertura lúdico-didáctica en la educación inicial
Authors: Álvarez-Galeano Manuel Felipe , García-Barros Nathaly Paulina , Crespo-Crespo Walter Benigno , Maza-Guillermo Erika Adriana
Published: June 2024

Esta investigación se apoya en la necesidad de fortalecer la educación artística, a partir del desarrollo estratégico de las técnicas grafoplásticas y la dactilopintura en el nivel Inicial de Ecuador, como herramienta de dinamización del pensamiento creativo, desde el resultado sustraído de los instrumentos curriculares y guías de la carrera de Educación Inicial de la Universidad Católica de Cuenca. Para tal fin, se tiene el objetivo de ponderar aportes de varios estudios, por medio de una sistematización propicia en función de la lúdica, para proceder con el diseño de una planificación pedagógica. Se opta por una metodología de enfoque cualitativo, corte no-experimental y de razonamiento deductivo-inductivo. Los resultados se organizan en una primera etapa de bosquejo teórico según el criterio de relevancia. Se procede con una secuenciación dividida en cinco sesiones de 30 minutos cada una, apoyada en los contenidos, destrezas y resultados de aprendizaje desagregados del Currículo Nacional.
Web-CMS based as teaching materials to improve students’ digital literacy
Authors: Setyasih Bina Rahayu , Supriyatin S. , Isfaeni Hanum
Published: June 2024

Technology advances and the profusion of information resources has the need to be accompanied by the students’ digital literacy and critical thinking skills. Website is the example of technological advances that are still rarely used as Content Management System (CMS) in learning. The purpose of this research is to develop website-based teaching materials to increase students’ digital literacy on material about cell. Research and development (R&D) conducted used ADDIE model. The development produces website-based teaching materials (Power Web Cell) which are later tested for the feasibility and the effectiveness in improving digital literacy of grade XI student on cell material. The product effectiveness test was caried out on 30 grade XI students who were selected using simple random sampling technique. The data was retrieved from digital literacy questionnaires measuring five areas. Hypothesis testing was conducted using paired sample t-test on pretest and posttest results. The results show that the developed Power Web Cell is feasible based on its feasibility tests’ result and is effective in improving students’ digital literacy. The content presented addresses more current issues and provides more interactive features, is recommended on developing website.
Analisis Hukum Permohonan PKPU atas Dasar Setoran Modal terhadap PT. X
Authors: Jennifer Andrea  , Marianus Yohanes Gaharpung  , Sylvia Janisriwati
Published: June 2024

Bali yang mempunyai nilai jual di bidang pariwisata memperkenalkan konsep wisata budaya dalam Peraturan Daerah Bali Nomor 5 Tahun 2020 tentang Standar Penyelenggaraan Pariwisata Budaya Bali tepatnya pada Pasal 1 Angka 12 yang menyatakan bahwa â€œWisata budaya Bali adalah Wisata Budaya Baliâ€. pariwisata berbasis budaya Bali yang dijiwai oleh filosofi Tri Hita Karana yang bersumber dari nilai budaya dan kearifan lokal Sad Kerthi serta berlandaskan Taksu Baliâ€. pariwisata berbasis budaya Bali harus berorientasi pada kualitas, sehingga diperlukan penataan yang komprehensif sesuai dengan visi pembangunan daerah Bali dan juga berorientasi pada keberlanjutan dan daya saing yang juga memerlukan standar penyelenggaraan pariwisata berdasarkan Tri Hita Karana. Perkembangan di Bali terlihat perubahan yang sangat besar, mengingat Bali merupakan destinasi wisata favorit dan juga salah satu pulau idaman yang ingin ditinggalkan oleh wisatawan baik domestik maupun mancanegara. Hal ini mengakibatkan krama (warga) desa yang tinggal di Bali tidak lagi hanya dihuni oleh krama (warga) asli Bali yang mempunyai ciri-ciri homogen tetapi telah berubah menjadi masyarakat yang heterogen. Hal ini tentunya menambah suku, ras dan agama bahkan negara yang memiliki komunitas atau krama berbeda yang tinggal di Bali. Dampaknya juga bisa menjadi pintu masuk budaya asing karena banyaknya wisatawan asing yang tinggal dan kesehariannya di Legian. Hal ini apabila tidak mendapat perhatian khusus dan tidak ada upaya penyaringan atau penyaringan budaya maka dikhawatirkan dapat merusak budaya asli Bali yang dipertahankan selama ini. Hal ini juga akan berdampak pada keberlangsungan wisata budaya yang dicanangkan pemerintah Bali.
Implementasi Perijinan Minimarket di Kota Denpasar
Authors: Ni Made Puspasutari Ujianti  , A. A. Sagung Laksmi Dewi  , Luh Putu Suryani  , Anak Agung Alit Ista Damayanti  , Made Sadhu Arta Kori
Published: June 2024

Perubahan gaya hidup dan pola konsumtif masyarakat kota yang bergeser menginginkan kemudahan dan serba praktis menyebabkan semakin maraknya pertumbuhan minimarket di kota besar khsusunya Kota Denpasar. Untuk mengantisipasi hal tersebut, Pemerintah Kota Denpasar telah membuat kebijakan Peraturan Walikota yang ditetapkan pada tahun 2009 yang diharapkan dapat mengatasi masalah penataan dan pembinaan pasar tradisional, pusat perbelanjaan, dan toko modern di Kota Denpasar. Pelaksanaan Penataan dan Pembinaan Pasar Tradisional, Pusat Perbelanjaan, dan Toko Modern di Kota Denpasar berdasarkan Peraturan Walikota Denpasar Nomor 9 Tahun 2009 wajib mengacu pada Rencana Tata Ruang Wilayah, dan Rencana Detail Tata Ruang termasuk Peraturan Zonasinya, pemenuhan syarat administrasi sebelum izin minimarket diterbitkan. Prosedur  dalam menerbitkan izin untuk minimarket di Kota Denpasar dilakukan oleh lintas instansi yakni Dinas Perijinan, Dinas Perindustrian dan Perdagangan, dan Dinas Pekerjaan Umum. Setelah izin diterbitkan Tim Teknis melakukan pengawasan untuk memastikan bahwa izin yang diterbitkan telah dilaksanakan sesuai dengan peruntukannya. Dalam pelaksanaan Peraturan Walikota Nomor 9 Tahun 2009 tentang Penataan dan Pembinaan Pasar Tradisional, Pusat Perbelanjaan dan Toko Modern ini belum dapat dikatakan berjalan dengan baik, hal ini dapat di lihat dari masih banyaknya minimarket yang berdisi tidak sesuai dengan Rencana Tata Ruang Wilayah Kota Denpasar. Hal ini dikarenakan masih adanya kepentingan yang mempengaruhi pelaksanaan kebijakan penataan minimarket ini. Kepentingan yang mempengaruhi kebijakan (interest affected) berkaitan dengan berbagai kepentingan yang mempengaruhi suatu implementasi kebijakan.
Childrenâ€™s Position on a Defective Marriage (Fasid) in Terms Establishment of Inheritance Right as an Effort for Legal Certainty
Authors: Haris Ivo Junia Imako
Published: June 2024

Marriage in the legal system in Indonesia is said to be valid if it is carried out according to each religion and belief and must be registered based on the applicable provisions. To avoid the occurrence of a defective marriage (fasid), then when a marriage has been carried out based on religion and belief, then the marriage must be registered. this is to avoid any legal consequences that will arise especially for children born in said marriage to the legal status and position of children born in defective marriages (fasid) as heirs. The purpose of this research is to find out the position of children born from broken marriages in terms of determining inheritance rights. This type of this research is normative, which is legal research conducted through library research. The findings of this study indicate that the legal status of children born from defective marriages (fasid) are children out of wedlock which the legal status is recognized by both parents and are not children born from acts of adultery. Regarding the right to inherit a child out of wedlock from a defective marriage (fasid) which has been proven through a DNA test to have a biological relationship with the father and his fatherâ€™s family, the father and his fatherâ€™s family as the heir can provide a testamentary grant through a legal act of a will grant which is proven by a notarial deed as a form of inheritance rights but the share may not exceed 1/3 of the heirâ€™s inheritance.