bluuebunny/crossref_metadata_2025 huggingface dataset:
Interval Metastases After Neoadjuvant Chemoradiotherapy for Patients with Locally Advanced Esophageal Cancer: A Multicenter Observational Cohort Study
Authors: van der Zijden Charlène J. , van der Sluis Pieter C. , Mostert Bianca , Nuyttens Joost J. M. E. , van Lanschot J. Jan B. , Spaander Manon C. W. , Valkema Roelf , Coene Peter Paul L. O. , Dekker Jan Willem T. , Fiets Willem E. , Hartgrink Hendrik H. , Hazen Wouter L. , Kouwenhoven Ewout A. , Nieuwenhuijzen Grard A. P. , Rosman Camiel , van Sandick Johanna W. , Sosef Meindert N. , van der Zaag Edwin S. , Lagarde Sjoerd M. , Wijnhoven Bas P. L.
Published: July 2024

Background

Despite trimodality treatment, 10% to 20% of patients with esophageal cancer experience interval metastases after surgery. Restaging may identify patients who should not proceed to surgery, as well as a subgroup with limited metastases for whom long-term disease-control can be obtained. This study aimed to determine the proportion of patients with interval metastases after neoadjuvant chemoradiotherapy (nCRT) and to evaluate treatment and survival.

Methods

Patients who had cT2-4aN0-3M0 esophageal cancer treated with nCRT were identified from a trial database. Metastases detected up to 14 weeks after nCRT on 18F-FDG-PET/CT or during surgery were categorized as oligometastases (≤3 lesions located in one single organ or one extra-regional lymph node station) or as non-oligometastases. The primary outcome was the proportion of patients with metastases after nCRT. The secondary outcomes were overall survival (OS) and the site and treatment of metastases.

Results

Between 2013 and 2021, 973 patients received nCRT, and 10.3% had interval metastases. Of 100 patients, 30 (30%) had oligometastases, located mostly in non-regional lymph nodes (33.3%) or bones (26.7%). The median OS of this group was 13.8 months (95% confidence interval [CI] 9.2–27.1 months). Of 30 patients, 12 (40%) with oligometastases underwent potentially curative treatment, with a median OS of 22.8 months (95% CI 10.4–NA). The patients with non-oligometastases underwent mostly systemic therapy or BSC and had a median OS of 9 months (95% CI 7.4–10.9 months).

Conclusions

Interval metastases were detected in about 10% of patients after nCRT, underscoring the importance of re-staging with 18F-FDG-PET/CT for those who proceed to surgery. A favorable survival might be accomplished for a subgroup of patients with oligometastases.
INNOVATIVE STRATEGIES FOR THE DEVELOPMENT OF THE UNIVERSITY'S ECOSYSTEM IN THE AGE OF DIGITAL TRANSFORMATION
Authors: Kiriliuk Olga M. , Zakharova Valeria D.
Published: July 2024

With increasing competition and a rapidly changing world, universities are forced to continuously improve their ecosystems. This is necessary to attract talented students and researchers, as well as to maintain a high level of academic reputation. All these changes are reflected in the development strategies of the university's ecosystems, contributing to their qualitative growth in the new reality.
In the era of the digital economy and the rapid development of information technology, universities are faced with the need to rethink their development strategies and adapt to new challenges. This is necessary to maintain competitiveness and achieve high results.
The authors consider innovative strategies for the development of university ecosystems as a tool to increase their efficiency in the era of digital transformation.
The purpose of the study: analysis of existing innovative strategies used by universities to develop their ecosystem in an era of digital transformation.
Materials and methods: the theoretical and methodological basis of the study is the results of the analysis of the works of domestic scientists, specialists in the field of strategic development of the university ecosystem. The conducted research is based on general and special methods of scientific knowledge: a systematic approach, methods of grouping, classification.
Results: the article accumulates information on the implemented innovative strategies for the development of the university ecosystem in the process of digital transformation.
Practical implications: the main results of the work carried out in terms of the study of trends and prospects for the development of the university's ecosystems are of interest to both theorists and practitioners, since the developed recommendations and strategies can be fully used in its work.
MECHANISM FOR MANAGING ORGANIZATIONS IN CONDITIONS OF IMPLEMENTING CHANGES
Authors: Chernyakova Maria M. , Zlotin Alexey V.
Published: July 2024

The article discusses the features of change management, which is a complex and diverse process and requires an integrated approach. Modern organizations, to improve their efficiency, use a combination of management mechanisms that are adapted to the type and scale of change.
Purpose: development of recommendations for effective change management in the organization.
Methods and materials. The work is based on the general scientific method of analysis and synthesis. Graphical methods were used to present the research results.
Research results. Important distinctive features of modern management of organizations are the consideration of fundamental values, such as taking into account key processes in the internal environment, dependence on external processes and management of organizations.
Scope of results. The article provides practical recommendations for organizations seeking to effectively manage change, identifies the importance of an individual approach, adapting management mechanisms in the context of change and the need for constant assessment and adaptation.
THE USE OF MODERN TECHNOLOGIES TO REDUCE THE COSTS OF LOGISTICS COMPANIES
Authors: Vergezova Ksenia S. , Platonova Anastasia A. , Zhulkova Julia N.
Published: July 2024

The paper is concerned with the possibilities of using innovative technologies at enterprises in the logistics industry. During the studying of this topic the authors of the article come to the conclusion that introduction of modern technologies presented in this article should not be limited exclusively to enterprises in the logistics industry. They can be used in different industries and fields of activity well. In examining the problem the authors point out that the practical realization of these techniques in combination can lead to significant positive structural changes in the company, to increase the motivation of employees to further use the implemented technologies and constantly search for new ways to reduce costs. In general, it can increase the efficiency of the company significantly.
Purpose. The aim of the research is to study modern technologies which are used at enterprises of the logistics and other industries. The objectives of the study are to determine their main directions.
Methodology. The article applies theoretical analysis, generalization of scientific literature, content analysis, systematization.
Results. There are directions of research in logistics by both foreign authors and domestic researchers. The authors point tо significant potential for their implementation in the modern period. It is the basis for further research in this area.
Practical implications. The scope of the results: managers of enterprises operating in the logistics industry can use the materials of the presented research. They can use it to make the choice of building the company development strategy and solving more specific tasks for example during personnel training.
What role do environmental factors play in the development of neurodegenerative diseases? A narrative review
Authors: Kuszneruk Julia , Chawrylak Katarzyna , Kłusek Magdalena , Kubas Maria , Krzemińska Katarzyna
Published: July 2024

Introduction and purposes: Degenerative diseases of the nervous system, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS). Environmental influences are significant contributors to the development of these conditions. The primary objective of this research was to examine key environmental factors that are suspected of their impact on the development of diseases, specifically lifestyle, medical conditions, diet and exposure to environmental pollution.
 
Materials and Methods: A systematic literature search was conducted using PubMed and Google Scholar. The search employed terms such as 'Alzheimer's disease,' 'Parkinson disease,' 'amyotrophic lateral sclerosis,' 'environment,' 'pollution,' 'diet,' 'traumatic brain injury,' 'alcohol,' 'obesity,' 'lifestyle factors'. The search included articles published from 2014 to 2024.
 
Results: Among environmental factors with regard to lifestyle choices, a healthy diet has a protective effect against these diseases, while alcohol consumption was not clearly categorised as harmful or protective. Among past illnesses, an increase in AD, PD after head injury was confirmed, but more research is required as to the impact on ALS incidence. Lipid metabolism disorders affect ALS morbidity, for the AD and PD, studies do not reach consensus. Similarly, with regard to body weight, studies do not clearly indicate whether it is relevant. On the contrary, when it comes to pollution, a lot of studies showed a correlation.
 
Conclusion: In summary, research studies varied in size and quality, so caution must be exercised in drawing conclusions. This review suggests that there is a relationship with the environment, and future research may focus on exploring these connections.
influence of physical activity on the health and treatment of schizophrenia patients
Authors: Kuśmierczyk Katarzyna , Jurga Marta , Karkos Patrycja , Kras Marta , Gastoł Bartłomiej , Mikołap Karolina , Staroń Arkadiusz , Ciołkosz Michał , Sztemberg Elena , Grajnert Filip
Published: July 2024

Schizophrenia is a chronic and severe mental illness that affects multiple areas of life. Patients with schizophrenia are prone to developing serious and even fatal disorders when it comes to their physical health. They have a higher mortality risk and an average of 14,5 years of potential life lost compared to the general population. Physical activity decreases mortality, reduces cardiovascular risk, and improves mental health. Within this article, we explore the topic of physical activity and its influence on the physical and mental health of schizophrenia patients and their treatment.
Swimmer’s ear: Prevention, Diagnosis, Treatment, and Management Strategies for Athletes
Authors: Lipska Julia , Hamerska Julia , Hamerska Laura , Bocianiak Bogumił , Antczak Joanna , Kajka Anna , Fenrych Urszula , Wojtczak Karolina , Skupińska Olga , Ruta Damian
Published: July 2024

Otitis externa, commonly known as a swimmer’s ear, is an inflammation of the external auditory canal, often caused by bacterial infection, primarily affecting individuals engaged in water activities. Acute otitis externa is the most prevalent form among swimmers, characterized by symptoms such as ear pain, itching, and discharge. This article explores the epidemiology, anatomy, pathogenesis, diagnosis, and treatment of otitis externa, highlighting the condition's prevalence in warm, humid climates and its exacerbation by water exposure.
Differential diagnosis is crucial to distinguish a swimmer's ear from other ear conditions, such as acute otitis media. Preventive measures, particularly for athletes, include the use of earplugs, drying ears after water exposure, and avoiding ear trauma. Treatment typically involves topical antibiotics, with the addition of corticosteroids to reduce inflammation and pain. Severe cases may require oral antibiotics or surgical intervention.
Complications of untreated otitis externa might lead to hearing loss and could be life-threatening. Early diagnosis and appropriate treatment are vital to avoid severe outcomes and ensure optimal recovery for athletes and other affected individuals.
Aim
The aim of this study is to gather and analyse the current state of knowledge about the pathogenesis, symptoms, diagnosis and the treatment of swimmer’s ear.
Methods
The study contains data available in freely accessible databases like PubMed, the National Library of Medicine, Google Scholar. While searching the keywords such as swimmer’s ear, otitis externa, swimming hygiene, ear infections were used. Articles were selected based on their title, abstract and were written in English.
Dangers in the use of systemic and local drugs expressed in eye disorders – a literature review
Authors: Ziemba Paweł , Janocha Aleksandra , Jerzak Aneta , Jakubowska Katarzyna
Published: July 2024

Introduction and purpose
Medications that have been available for many years are commonly used to treat various illnesses. However, nearly all of them can also have toxic effects on other organs, including the eyes, in addition to their therapeutic benefits. In this review, we discuss chosen drug-induced eye disorders, their specific clinical characteristics, and the mechanisms by which certain drugs can damage the ocular system. Isotretinoin and certain chemotherapy drugs are known to contribute to the development of dry eye syndrome. Atimalarial drugs, amiodarone, nonsteroidal anti-inflammatory drugs and chlorpromazine cause the formation of corneal deposits. Prolonged use of glucocorticoids leads to the development of characteristic posterior subcapsular cataracts. The development of cataracts can also be caused by the use of antipsychotic medications. Paradoxically, drugs used topically to treat glaucoma or other eye diseases may trigger an acute attack of angle-closure glaucoma.
Materials and methods The methodology for conducting literature search involved utilizing medical subject headings terms to explore PubMed. Search terms included: “drug-induced dry eye disease”, “drug-induced cataract”, “drug-induced glaucoma”, “drug-induced corneal damage”.
Conclusions Educating patients about the potential ocular side effects of newly introduced treatment is crucial so that they can quickly consult an ophthalmologist if symptoms occur. Adjusting the dosage or discontinuing the drug may alleviate ocular symptoms, but these changes must be considered in light of the overall risk posed by the underlying disease. Every treatment should aim to offer the patient maximum benefits while minimizing any adverse impact on their quality of life.
High-Intensity Interval Training - health benefits and risks - literature review
Authors: Plizga Jakub , Jaworski Arkadiusz , Grajnert Filip , Gluszczyk Agnieszka , Surma Alicja , Cecot Jakub , Parfianowicz Agnieszka , Zarzecki Konrad , Mandryk Miłosz , Holdun Nazar
Published: July 2024

High-Intensity Interval Training (HIIT) has become a prominent exercise modality known for its efficiency and effectiveness in improving various health outcomes. This review critically examines the positive and negative health aspects of HIIT, focusing on its impact on cardiovascular health, metabolic function, weight management, psychological well-being, and life expectancy. Evidence suggests that HIIT significantly enhances cardiovascular health by improving VO2 max, reducing blood pressure, and enhancing endothelial function. Metabolically, HIIT improves insulin sensitivity, glucose metabolism, and lipid profiles, while effectively reducing visceral fat and enhancing mitochondrial function. In terms of weight management, HIIT promotes fat loss and muscle maintenance, contributing to favorable body composition. Psychologically, HIIT has been shown to reduce symptoms of anxiety and depression, improve cognitive function, and enhance overall mental health. It has also a positive effect on chronic pain conditions. Emerging studies indicate that HIIT may reduce mortality risk and extend life expectancy by improving cardiovascular and metabolic health. Despite these benefits, HIIT also presents risks such as a higher incidence of musculoskeletal injuries, potential adverse cardiac events in high-risk individuals, and the risk of overtraining and burnout. Special populations, including older adults, children, adolescents, and individuals with chronic conditions, can benefit from HIIT, but modifications and precautions are necessary to ensure safety and effectiveness. The review underscores the importance of individualized HIIT program design, thorough assessment, and continuous monitoring to maximize benefits while minimizing risks. Future research should focus on long-term effects, optimal protocols for diverse populations, and personalized HIIT approaches to enhance safety and efficacy.
Mental health in the focus of social work
Authors: Plakhova Olena ,   V. N. Karazin Kharkiv National University
Published: July 2024

The article updates the problem of preserving the mental health of Ukraine population under conditions of war. The author emphasizes that mental health affects not only emotions, behavior, communication, but also thinking, decision-making process, and social well-being of people. The author notes that in Ukraine, the potential of social work in the field of mental health is not sufficiently used in comparison with international practice. Although there are many methods of prevention of mental health disorders and its preservation in social work. These are social rehabilitation, counseling, crisis intervention, social support, etc. Social work involves assistance in recognizing mental health difficulties (needs audit), establishing contact, direct support, referral for professional help and tracking of its getting. A social worker (social assignment manager, case manager) connects people with activities and services in the local community that can help improve their mental health and well-being. The author of the article provides examples of the activities of social workers in the field of mental health support, which have become widespread in the USA, and which can be useful for the domestic practice of social work. It is clinical social work that aims to solve the problems of people with mental illness and treat their condition. School social work, which provides practical help to children and adolescents with existing and potential mental problems. Substance abuse social work specializing in the diagnosis and treatment of addiction. Social work with military personnel, their family members, and veterans to preserve their mental health.
Strategies for improving psycho-emotional state and resilience skills formation in socially vulnerable groups during the state of war in Ukraine
Authors: Tashkinova Oksana ,   Pryazovskyi State Technical University, Rohovska Olha , Radionova Tetiana ,   Pryazovskyi State Technical University,   National social service service in Donetsk region
Published: July 2024

The article explores the issue of implementing and realizing strategies for improving the psycho-emotional state and forming resilience skills in socially vulnerable groups during the state of war in Ukraine. An analysis of the results of nationwide research on the psycho-emotional state of Ukrainians conducted during the period from 2022 to 2024 is provided. It is established that socially vulnerable groups of the population, such as internally displaced persons, war veterans, people with disabilities, and others, face significant difficulties associated with deteriorating psycho-emotional states and adapting to stressful situations. The paper discusses various aspects related to effective stress management strategies and psycho-emotional reactions that can be beneficial for these population groups. The article emphasizes that ensuring psychological resilience of the population, especially representatives of vulnerable groups, is a key task for contemporary Ukrainian social policy. The article discusses possible ways to support and develop resilience skills that can have a positive impact on the psycho-emotional state and overall quality of life of these groups. Special attention is paid to the introduction of a new psychosocial service for resilience building. The importance of implementing innovative educational programs for auxiliary professions specialists to ensure quality psychosocial support to the population and formation of resilience skills is underscored. Special attention is given to the analysis of decentralization and provision of psychosocial services at the level of territorial communities through the establishment of Resilience Centers. This allows ensuring the accessibility and quality of services for the local population. Analysis of these issues will help broaden the understanding of mental health problems in the population and provide more effective support for those who need it most.
Current directions of socio-pedagogical work with families in armed conflict conditions
Authors: Kharchenko Liudmyla ,   State Institution Luhansk Taras Shevchenko National University, Shabaeva Nataliia ,   State Institution Luhansk Taras Shevchenko National University
Published: July 2024

The article deals with an important problem of today – the search for actual areas of socio-pedagogical work with families in conditions of armed conflict. A special place in the context of this issue is occupied by the figure of a social pedagogue, because a specialist in the socio-pedagogical sphere of activity works with families who have lost relatives, housing, were separated from loved ones or were forced to leave their homes, were under shelling, temporary occupation, suffered torture and violence. Among the current directions of socio-pedagogical work with families in the armed conflict, we included - the study of the potential possibilities of the family and the influence of external factors on it for further work; interaction with various state institutions and public organizations on issues of assistance to victims of armed conflict; informing the participants of the educational process about the activities of formal (state) and informal organizations (charity funds), which help overcome the consequences of the war; control over the education of children and adolescents from the families of forced migrants; teaching parents specific ways and techniques of working with a child in times of crisis and emergency situations (consequences of rocket fire – destruction of residential buildings, infrastructure, fire, power supply restrictions, etc.). Individual and/or family online/offline consultations, lectures, therapy groups, child-parent communication clubs, family group meetings, youth clubs, dialogue groups, training sessions on the development of life skills, telephone counseling should be the forms of implementation of the outlined areas of social and pedagogical work; methods – persuasion, suggestion, example, training, creation of educational situations, encouragement, approval, selfeducation. The advantage of these forms and methods of work is that they are completely independent, depending on the situation, they can be carried out both stationary and remotely.
Benchmarks for developing future socionomic professionals’ pedagogical reflection via foreign language training
Authors:   Khmelnytskyi National University, Kravchyna Tetiana
Published: July 2024

In today’s globalized society, the demand for professionals equipped with both specialized knowledge and comprehensive intercultural communication skills is at an all-time high. This is particularly true in the field of socionomics, where understanding social and economic dynamics across cultures is crucial. The integration of foreign language training into the development of pedagogical reflection presents a novel approach to preparing future socionomic professionals for the challenges of a multicultural world. Despite the clear need for enhanced intercultural competence among future professionals, current educational models often compartmentalize language learning and professional training, overlooking the potential synergies between linguistic skills and pedagogical reflection. This gap limits students' ability to effectively apply theoretical knowledge in diverse cultural contexts and hinders their development as globally competent professionals. The study proposes a set of benchmarks aimed at integrating foreign language training with the development of pedagogical reflection in socionomic education. The essential components encapsulated within these benchmarks are: intercultural competence, advanced cognitive and metacognitive abilities, reflective practice in foreign language training, language proficiency as a tool for pedagogical innovation, professional development and lifelong learning. The integration of foreign language training with pedagogical reflection not only enhances the linguistic and cultural competence of future socionomic professionals but also fosters a deeper, more nuanced understanding of their field. By adopting this comprehensive approach, educational institutions can better prepare students for the complexities of working in a globalized socio-economic landscape, ultimately contributing to more effective and empathetic professional practices.
Make the most of pupil premium funding to tackle disadvantage
Authors: Shaw Nancy , Burls Kate
Published: July 2024

Experts from the Education Endowment Foundation explain how latest guidance on the pupil premium is is an opportunity for schools to review how funding is used and introduce a tiered model of spending
Shifting power in youth justice
Authors: Burns Samantha , Creaney Sean
Published: July 2024

Youth justice services need to adopt a more collaborative approach with young people, say experts
STC assurance visits
Authors: Stephenson Jo
Published: July 2024

Ofsted's Yvette Stanley answers 10 key questions from Jo Stephenson about how new assurance inspections for secure training centres will work and the improvements they will bring for children
Nonstandard Finite Difference Time Domain Methodology to Simulate Light Propagation in Nonlinear Materials
Authors: Cole James B.
Published: July 2024

We extend the nonstandard (NS) finite difference time domain (FDTD) methodology, originally developed to solve Maxwell’s equations in linear materials, to nonlinear ones. We validate it by computing harmonics generation in a nonlinear dielectric and comparing with theory. The methodology also applies to the quantum electrodynamics that describes the interaction of charged particles with electromagnetic fields, and also to the Ginzburg-Landau model of superconductivity.
Impact Evaluation of an External Point Source to a Generalized Model of the Human Neck
Authors: Varvari Anna A. , Karatzidis Dimitrios I. , Ohtani Tadao , Kanai Yasushi , Kantartzis Nikolaos V.
Published: July 2024

A methodical approach for assessing the effects of an external point source to a non-spherical model of the human neck is presented in this paper. The neck model consists of multilayered spheres to represent the skin, fat, muscle tissues, thyroid, and esophagus. The novel geometry enables the formulation of dyadic Green’s functions to accurately calculate the electric fields, considering the suitable surface boundary conditions and the superposition principle. Numerical outcomes for a Hertz dipole (i.e., a wireless network antenna) at the frequency of 2.4 GHz certify the benefits of the technique and elaborately describe the responsiveness of the neck/thyroid to the selected source.
Wideband Low-Profile Fabry-Perot Cavity Antenna with Metasurface
Authors: Song Xueyan , Dong Ang , Li XuPing , Zhang YunQi , Lin Haoyuan , Yang Hailong , Li Yapeng
Published: July 2024

A novel Fabry-Perot cavity (FPC) antenna with metasurface is presented, which can achieve broad bandwidth and low profile. Traditional FPC antennas, with rectangular microstrip antennas as feeds, have limited impedance bandwidth and struggle to make a compromise in the gain bandwidth and maximum gain value. To obtain wide bandwidth, the FPC antenna proposed in this paper utilizes a feed antenna loaded with parasitic patches. To widen impedance bandwidth and gain bandwidth and reduce the profile, a positive phase gradient partially reflective surface (PRS) and an artificial magnetic conductor (AMC) are located above and below the feed antenna, respectively. The phase property of the PRS and AMC also brings in a more smooth gain value curve. To further increase gain values, four metal reflector plates are located around the proposed antenna. The overall dimension of the antenna is 2.5λ0×2.5λ0×0.25λ0 (λ0 is the free space wavelength at 7.5 GHz). Simulated results show that the resonant cavity antenna proposed in this letter exhibits an impedance bandwidth of 13.3% (7–8 GHz) and a 3 dB gain bandwidth of 14.3% (7.02–8.10 GHz). The maximum gain in the whole operating band is 14.5 dBi. The measured results are in good agreement with the simulated ones.
Neuroblastom i Wilmsov tumor - standard liječenja
Authors: Stepan Giljević Jasminka
Published: July 2024

The paper presents the basic characteristics and standard of treatment for neuroblastoma and Wilms tumor. The age at which these tumors appear is related to an earlier age. Neuroblastoma occurs slightly more often in boys, while nephroblastoma occurs slightlymore often in girls. The localization and stage of the disease define the clinical presentation. Neuroblastoma occurs more often as a metastatic disease with the possibility of developing a paraneoplastic syndrome, while Wilms tumor occurs more often as a localized disease. After the initial diagnosis, which determines the stage and risk of the disease, neoadjuvant chemotherapy is started. After the reevaluation, an operation follows, followed by postoperative chemotherapy. Nephrectomy is still used in the operative treatment of unilateral Wilms tumor. The residual kidney tissue is preserved in the bilateral Wilms tumor and an individual approach is implemented. Low-risk neuroblastoma can be treated with observation, chemotherapy, and surgery. Megatherapy and autolo-gous stem cell transplantation are used in the treatment of high-risk neuroblastoma, followed later by immunotherapy and retinoid therapy. Radiotherapy is used in advanced stages of Wilms tumor and in high-risk neuroblastoma. The use of the radioactive isotope meta-iodobenzylguanidine (MIBG) is also possible in the treatment of neuroblastoma. Rapid diagnosis and intensity of treatment defined by the risk of tumor disease with the use of appropriate supportive therapy are the basis of care for neuroblastoma and Wilms tumor.
Uloga kirurgije u liječenju solidnih tumora dječje dobi
Authors: Keretić Dorotea , Car Andrija , Mesić Marko , Kralj Rok , Petračić Ivan , Miljanović Vrđuka Veronika , Višnjić Stjepan
Published: July 2024

Objective: The objective of this paper is to present the spectrum of surgical procedures that we perform for the purpose of treating oncological patients and the role of surgeons in oncological treatment.Methods: The PubMed medical database was searched with reference to the basic literature in pediatric surgery.Results: By searching and excluding, 18 recent works were considered along with 2 pediatric surgery books on the topic of surgical treatment of solid tumors in childhood. There were no exclusion parameters.Conclusion: The role of surgery in pediatric oncology during the 20th century changed it is position starting from the first and only option for small patients to it is place in the worldwide accepted treatment protocols. The surgical techniques we use in the diagno-sis and treatment of childhood tumors continuously evolve according to a specific type of tumor. Methods that were also previously acceptable are now becoming more and more meticulous to preserve the patient’s quality of life and fertility. Surgical techniques include tumor biopsy methods, surgery of tumor`s primary site (extirpation of tumors, resection of organs or organ systems), staging of tumors according to anatomic extension, operations for disease relapse and metastases, and palliative and supportive procedures. The role of surgery in the prophylaxis of oncological disease is also well defined for various predisposing syndromes and diseases. The most important aspect of surgical oncological treatment is strict adherence to and familiarity with the protocol for a certain type of tumor, as well as a multidisciplinary and individual approach to the pediatric oncologic patient.
Metode nuklearne medicine u dijagnostici i lije?enju neuroblastoma visokog rizika ? prikaz slu?aja
Authors: Gladić Nenadić Vedrana , Rajacic Nada
Published: July 2024

Neuroblastoma is childhood’s most common extracranial solid tumor, with a broad spectrum of biological conduct. The high-risk disease encompasses a significant portion of childhood cancer mortality. Nuclear medicine methods, including disease risk categorization, are essential in the diagnostic process. However, nuclear medicine has its place as a segment of the multidisciplinary treatment of high-risk diseases, too. In this article, a patient diagnosed with high-risk neuroblastoma due to age and metastases is presented, with an accent on the role of nuclear medicine and a multidisciplinary approach in diagnostic and therapeutic procedures.
ODREĐIVANJE PROGNOSTIČKOG RIZIKA TUMORSKE BOLESTI KOD DJECE SA SOLIDNIM TUMORIMA
Authors: Jakovljević Gordana
Published: July 2024

Ista tumorska bolest  kod različitih bolesnika   može imati  različitu prognozu, odnosno dužinu preživljenja. S ciljem individualizacije terapije i poboljšanja liječenja pedijatrijskih malignih tumora, intenzitet i vrsta liječenja iste tumorske bolesti kod razičitih bolesnika  mo?e biti različita. Razlike u liječenju određene su stupnjem rizika, odnosno prognostičkim čimbenicima rizika. Prognostički čimbenici rizika utječu na ishod liječenja i preživljenje.
Mjesto zbrinjavanja djetetasa solidnim malignim tumorom u Hrvatskoj
Authors: Bilić Ernest , Jelic Matej
Published: July 2024

Malignant diseases in the paediatric population are rare and account for only 0.5% of all newly diagnosed malignant diseases. In Croatia, 105 to 125 children are diagnosed with malignant diseases every year. As in most countries of the European Union, they are the second most common cause of death in this age group, after accidents. Treatment outcomes for children with malignant diseases in Croatia are comparable to those in other countries of the European Union. Due to the small number of patients, only slightly more than one hundred new patients per year, it would be necessary to centralize the treatment of all high-risk patients. Such children should be treated in two centers, one of which would be a center for solid tumors and the other a center for haematological neoplasms. Such an approach would probably allow an additional improvement in treatment outcomes with practically same resources.
Entangled places of the anthropocene – A journey
Authors: Berendt Zuzanna
Published: July 2024

What I would like to propose within this text is an imaginary journey to three places: Amanda Piña’s Climatic Dances (2020), Katharina Joy Book’s and Ester Koncz’s Tornado Watch (2021) and Agata Siniarska’s Den (2022). These are places of complex topography – performances that were shown on particular stages, but also referred to and drew on the qualities of other locations. These are places produced by movement – movement of bodies, objects, sounds, rays of light, thoughts and imaginations. These are also places that do not exist at this very moment in the way they existed when bodies and objects moved through them while being perceived by the audience. But perhaps some of them will reappear; it’s all a matter of the right circumstances. From each of these places I learned something about what a place is when it ceases to be an abstract, humanistic idea of space. Every one of them produces a certain kind of ecognosis.
New tactics and strategies for the development of the independent cultural scene
Authors: Tanurovska-Kjulavkovski Biljana
Published: July 2024

In hereby republished chapter from Biljana Tanurovska-Kjulavkovski’s book*, the work of the nongovernmental organisations in North Macedonia in relation to the public space will be observed. Space(s) will be regarded as environments where established processes are realised or actions are effectuated – made visible. In the past (the period between 2000 and 2010) I identified two strategies of development of organisations in the independent sector: 1. creation of new spaces, and 2. creation of temporary platforms within institutions. From 2010, another approach and trend can be identified – networking or affiliations and development of co-governing models (public-private-civil partnerships).
Appendiceal Adenocarcinoma Presenting as Palpable Breast Masses
Authors: Swied Muhammed Yaman , Al Turk Yahia , Maitar Michael
Published: July 2024

Appendiceal tumors are rare and are most commonly diagnosed incidentally during surgical removal of the appendix for acute appendicitis. Appendiceal adenocarcinomas are the most common appendiceal cancers, and their metastasis to the breast is extremely uncommon. We report a case of mucinous appendiceal adenocarcinoma presenting with breast metastasis. To the best of our knowledge, there has been only one case published in the literature about appendiceal cancer with metastasis to the breast. Interestingly, our patient's initial presentation was palpable breast masses rather than gastrointestinal symptoms.
Crohn's Disease–Associated Granulomatous Pancreatitis With Exocrine Pancreatic Insufficiency
Authors: Xu Anthony A. , Vincent Sara , Ma Samuel , Catania Vanessa , Zarrin-Khameh Neda
Published: July 2024

Extraintestinal manifestations of inflammatory bowel disease occur commonly and can lead to considerable morbidity. Pancreatic manifestations of inflammatory bowel disease have been reported to be more common in Crohn's disease (CD) than ulcerative colitis. We report a case of granulomatous inflammation in the body of the pancreas with exocrine pancreatic insufficiency, which prompted a diagnosis switch from ulcerative colitis to CD. This is of interest to readers to remind them that pancreatic manifestations can occur and are more common in CD.
Idiopathic Multicentric Castleman Disease With Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Insufficiency, and Organomegaly (TAFRO) Syndrome in a Liver Transplant Recipient
Authors: Mashal Fares A. , Awad Joseph A. , Tillman Benjamin F. , Mosse Claudio A. , Thandassery Ragesh B.
Published: July 2024

Idiopathic multicentric Castleman disease is a rare lymphoproliferative disorder that can be potentially fatal without timely diagnosis and treatment. We describe the first-ever reported occurrence of idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis/renal insufficiency, and organomegaly syndrome in a liver transplant recipient. The diagnosis was challenging as the clinical presentation closely mimicked decompensated cirrhosis, and the profound thrombocytopenia limited tissue diagnosis. However, we were able to establish the diagnosis and treat it effectively. This case report signifies that a high index of suspicion and aggressive treatment can be lifesaving in liver transplant recipients presenting with this rare disorder.
Extraosseous Ewing Sarcoma With Upper Gastrointestinal Bleeding
Authors: Yadav Ajay Kumar , Shrestha Milan , Rajbhandari Sabin , Kafle Roshan , Shrestha Swarup , Khadka Dibas , Poudel Saugat , Paudel Mukesh
Published: July 2024

Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a type of malignancy that usually appears as a tumor in the bone. However, in a few patients with ES/PNET, it can occur outside of the bone. Although extraosseous ES/PNET can appear in various parts of the body, involvement of small bowel is rare. If it does, it can present with vague abdominal pain and gastrointestinal bleeding. This case report presents a 28-year-old gentleman with extraosseous ES/PNET in the duodenum who experienced gastrointestinal bleeding as a presenting symptom.
Endoscopic Deployment of Cardiac Septal Occluder Device to Close an Enterovaginal Fistula
Authors: Edelson Scott F.D. , Edelson Cyrus V. , Jones Jacob , Quiles John G.
Published: July 2024

Enterovaginal fistulas (EF) are a rare, pathologic connection between the small bowel and vagina. EF commonly present with abnormal passage of stool, flatus, and purulence through the vaginal orifice, leading to increased risk of severe infections, and cause extreme discomfort for patients. A 70-year-old woman with a history of urothelial carcinoma was treated surgically, resulting in a persistent symptomatic EF. Her course was complicated by multiple failed surgical attempts to fistula closure. Ultimately, she was deemed a poor surgical candidate. Gastroenterology successfully closed her fistula using a cardiac occluder device. This case highlights an innovative solution to treat patients with refractory fistulas.
Automatic toll collection system using RFID with vehicle classification using convolutional neural network
Authors: Bhanu Teja T , Hari kumar N , Sasi Raja Sekhar D , Shiva Kumar C
Published: July 2024

The need for efficient and secure toll collection systems has prompted the development of advanced technologies that streamline toll collection and enhance traffic management. This paper presents an automatic toll collection system that integrates Radio Frequency Identification (RFID) technology with vehicle classification using convolutional neural network algorithms. The proposed system aims to improve the accuracy and efficiency of toll collection processes while reducing illegal use of Fast-tags (RFID) on unauthorized vehicles. The RFID-based component of the system facilitates contactless payment by detecting vehicles equipped with RFID tags as they approach the toll booth. The system automatically processes the payment, enabling swift passage for vehicles and minimizing delays. To enhance security and accuracy, the system incorporates a vehicle classification module based on Single Shot Detector (SSD) and You Only Look Once (YOLO) models. Cameras capture images of approaching vehicles, which are then processed by CNN algorithms trained to classify vehicles based on features such as type, make, model and Size. This classification enables the system to apply appropriate toll rates according to vehicle category and ensure compliance with toll regulations. The integration of RFID and deep learning technologies provides a robust approach to managing toll collection, minimizing fraud or evasion, and ensuring a seamless experience for drivers. The proposed system also offers valuable data insights for traffic analysis and management, contributing to smarter transportation infrastructure like toll fee SMS services and automatic toll gate opening and closing system. The results demonstrate that the system significantly improves the efficiency and accuracy of toll collection while providing a reliable and secure method for vehicle classification. The proposed system holds potential for widespread adoption, aligning with the growing demand for intelligent transportation solutions.
Securing data transmission by cryptography using Rohit integral transform
Authors: Rohit Gupta  , Rahul Gupta
Published: July 2024

The encryption and decryption processes to secure data transmission and protection in cryptography are very useful in a communication system for authentication and privacy. Recently, integral transform techniques have been used by many researchers to increase the strength of encryption and decryption processes in cryptography. In this paper, the ability of Rohit integral transform (RIT) is shown for the encryption and decryption processes in cryptography and in general, in the field of data security through practical application.
Revolutionizing industry: the path to sustainable manufacturing
Authors: G. Pungle Ramesh
Published: July 2024

In the Industrial Revolution, manufacturing has been a cornerstone sector. With each industrial revolution, the focus has been on optimizing the utilization of resources, including manpower, machinery, and materials. Industries aim to enhance manufacturing efficiency to meet societal demands, increase profitability, advance technology, and maintain product quality and variety. This paper illuminates the transitions from Industry 1.0 to 5.0, highlighting technological advancements, benefits, and challenges. Challenges encompass adverse environmental impacts, extensive consumption of natural resources for energy, escalating industrial waste, and an imbalanced industrial ecology. Furthermore, this paper delves into the domain of sustainable manufacturing, tracing its evolution across the industrial revolutions. It elucidates how sustainable manufacturing has emerged as a pivotal concept, grounded in industrial ecology principles and the circular economy. These complementary components are instrumental in promoting not only sustainable manufacturing practices but also sustainable development on a broader scale. Through an in-depth examination, this paper aims to separate out the intricate relationship between these concepts, providing insights into their significance and potential to foster a more environmentally conscious and resilient industrial landscape.
Superluminal graviton condensate vacuum
Authors: Markoulakis Emmanouil N.
Published: July 2024

In this study, we argue fundamentally and physically on the nature of the graviton as the only elementary particle in the universe, constituting the fabric of vacuum spacetime and all matter and all energy forms. We demonstrate that the universe's functioning is consistent with the current laws of physics and that a non-tachyonic graviton string-particle carrying superluminal energy exists. The graviton model proposed herein unifies dark energy, quantum gravity, and dressed zero-point vacuum energy field in a single energy manifold. The model provides an alternative interpretation of the vacuum energy, the dark energy, and the cosmological constant value as well as an explanation for the cosmological “coincidence problem”. Our model describes the zero-point vacuum energy as an evaporation product of hidden compacted extra dimensions superluminal energy of the universe, rather than being due to any supersymmetry fine-tuned fields cancellation. Furthermore, the proposed model also predicts how the graviton's superluminal oscillation is ticking down the remaining lifetime of the universe, acting as a cosmological clock. Spacetime should end after a Big Freeze or a Big Rip scenario governed by a global vacuum instantaneous catastrophic event, to which a new cycle of Big Bang follows. Our model explains why the massless spin 2 in-place superluminal vibrating graviton and condensate consisting everything including spacetime must be essentially the only massless cold boson elementary particle and why fundamentally the vacuum is superluminal condensate energy. An experiment with the Atlas detector is proposed to indirectly verify the theory by measuring potential superluminal propagation of dark photons. Essentially, the research reveals that the entire dark sector consists of superluminal energy, making it directly undetectable. Additionally, it suggests that quantum gravity originates from the dark sector.
Experimental study on partial replacement of fine aggregateby lathe steel waste with natural fibre in concrete
Authors: Pooja S Lachyan  , Fajal Mohammad Shaikh  , Vinayak Raghunath Patil  , Saurabh Mahendra Rajguru  , Om Roopchand Pawara  , Ganesh Babasaheb Sathe
Published: July 2024

This topic focused on bettering concrete properties by replacing traditional materials with waste products, like from the steel industry, andincorporating natural fibres. The aim of this research are to mitigating environmental hazards connected with industrial waste while improving concrete performance. The studies investigated the feasibility of using steel lathe waste as a partial replace for fine aggregate inconcrete, along with including coconut Fiber for some reason. Through experimental analysis, the percent of lathe scrap replacement andnatural fibre incorporation is determined to achieve the mechanical properties wanted. The research assesses the compressive, tensile, andflexural strengths, as well workability and consistency of the concrete mixes - important stuff. Additionally, durability and resistance toenvironmental factors are being looked at. Comparative analysis includes figuring out cost-effectiveness with traditional concrete, eventhough it might be obvious. The project's scope includes a rather comprehensive investigation into the benefits and challenges of thesealternative materials, contributing to sustainable construction practices, and minimizing environmental impact.