bluuebunny/crossref_metadata_2025 huggingface dataset:
AMP activated kinase negatively regulates hepatic Fetuin-A via p38 MAPK-C/EBPβ/E3 Ubiquitin Ligase Signaling pathway
Authors: Kothari Vishal , Babu Jeganathan Ramesh , Mathews Suresh T.
Published: May 2022

Fetuin-A (Fet-A) is a liver-secreted phosphorylated protein, known to impair insulin signaling, which has been shown to be associated with obesity, insulin resistance, and incident diabetes. Fet-A interacts with the insulin-stimulated insulin receptor (IR) and inhibits IR tyrosine kinase activity and glucose uptake. It has been shown that high glucose increases Fet-A expression through the ERK1/2 signaling pathway. However, factors that downregulate Fet-A expression and their potential mechanisms are unclear. We examined the effect of AMP-activated protein kinase (AMPK) on high-glucose induced Fet-A expression in HepG2 cells, Hep3B cells and primary rat hepatocytes. High glucose increased Fet-A and phosphorylated (Ser312) fetuin-A (pFet-A) expression, which are known to impair insulin signaling. AICAR-induced AMPK activation significantly down-regulated high glucose-induced Fet-A expression and secretion of pFet-A while treatment with Compound C (AMPK inhibitor), SB202190 (p38 MAPK inhibitor) or p38 MAPK siRNA transfection prevented AICAR-induced downregulation of Fet-A expression. In addition, activation of p38 MAPK, by anisomycin, decreased the hepatic expression of Fet-A. Further, we our studies have shown that short-term effect of AICAR-treatment on Fet-A expression was mediated by proteosomal degradation, and long-term treatment of AICAR was associated with decrease in hepatic expression of C/EBP beta, an important transcription factor involved in the regulation of Fet-A. Taken together, our studies implicate a critical role for AMPK-p38 MAPK-C/EBPb-ubiquitin-proteosomal axis in the regulation of the expression of hepatic Fet-A.
Health versus income amid COVID-19: What do people value more?
Authors: Palma Marco A. , Huseynov Samir , Nayga Rodolfo M.
Published: May 2022

Public efforts to battle COVID-19 have been portrayed as a trade-off between health and the economy in the U.S. public discourse. We investigate how the U.S. general public prioritizes the health and the income dimensions amid COVID-19 using an incentivized instrument with real monetary consequences. We also employ between-subject information treatments highlighting negative health and income consequences of the pandemic. Specifically, participants have to divide monetary contributions between two charitable organizations representing either the health or the income dimension. An overwhelming majority of participants supports both dimensions, with higher monetary contributions to the health dimension (56%) compared to income (44%), but the difference is not large. Only a small fraction of respondents contributes exclusively to the health (10%) or income (5%) dimensions. Increasing the salience of negative health outcomes of COVID-19 raises differential token allocations in favor of the health-oriented charity. This finding is important since the course of COVID-19 will be shaped by the policies governments implement and how the general public reacts to these policies.
Predicting young Chinese consumers’ intentions to purchase Western brands: Structural model analysis
Authors: Long Fei , Bhuiyan Miraj Ahmed , Aziz Norzalita Abd , Rahman Muhammad Khalilur
Published: May 2022

This study aims to investigate how young Chinese consumers make purchase intentions towards Western brands under the influence of two conflicting values and CSR, which is insufficiently discussed in the current literature. Both value-attitude-behavior (VAB) and consumer cultural theories are adopted to construct the research framework. Data was collected from undergraduate students studying at a public university located in Guangzhou via WeChat and Tencent QQ. A total of 314 usable responses were analyzed by the partial least squares structural equation modeling (PLS-SEM). The empirical findings indicated that cosmopolitanism has a significantly positive effect on brand attitudes and purchase intentions; ethnocentrism has a significantly negative effect on purchase intentions, but no significant impact on brand attitudes; and corporate social responsibility (CSR) initiatives positively affect brand attitudes rather than purchase intentions. The results also revealed that brand attitudes mediate the relationship between cosmopolitanism/CSR and purchase intentions, but it does not have a mediating effect on the relationship between ethnocentrism and purchase intentions. These findings provide essential insights to the body of knowledge of international marketing in emerging markets and shed light on understanding how young Chinese consumers make purchase decisions towards Western brands. The results are useful for Western brands to effectively adjust their marketing strategies and advertising/promoting campaigns for business development purposes in the Chinese market.
Macrophage activation syndrome in rheumatic disease: Clinical characteristics and prognosis of 20 adult patients
Authors: Nam So Hye , Ahn Soo Min , Oh Ji Seon , Hong Seokchan , Lee Chang-Keun , Yoo Bin , Kim Yong-Gil
Published: May 2022

Objectives

Macrophage activation syndrome (MAS) is a hyperinflammatory condition that is known to be secondary hemophagocytic lymphohistiocytosis (HLH) in patients with rheumatic disease. The aim of study was to evaluate the clinical manifestations and outcomes in patients with MAS with rheumatic disease.

Materials and methods

We performed a retrospective study of 20 adult patients who were diagnosed with MAS from 2012 to 2020. MAS was classified according to the HLH-2004 criteria. Patients’ information, including clinical features, laboratory findings, and treatment regimens, was collected, and the overall survival rate was estimated by the Kaplan–Meier method.

Results

Twenty patients (18 women, 35.6 ± 18.3 years) who met the HLH-2004 criteria also fulfilled the 2016 EULAR/ACR/PRINTO classification criteria for MAS, and HScore was higher than 169 (mean, 241.1). Fourteen patients with systemic lupus erythematosus and 6 patients with adult-onset Still’s disease were included. All patients were treated initially with corticosteroids, and 16 patients required additional immunosuppressants. The overall survival at 3 and 6 months was 75.2% and 64.3%. In survivors, renal impairment was less common (7.7% versus 71.4%, p = 0.007), the levels of AST (364.0 versus 81.0 IU/L, p = 0.019) and LDH (1346.0 versus 343.0IU/L, p = 0.014), and platelet count (90.0 versus 43.0 × 109/L, p = 0.02) were higher in compared to non-survivors. Nine patients had opportunistic infections, five of whom died during admission.

Conclusion

The mortality of patients with MAS associated with rheumatic disease remains high. Renal impairment, levels of AST and LDH, and platelet count might be associated with prognosis.
Voice activated remote monitoring technology for heart failure patients: Study design, feasibility and observations from a pilot randomized control trial
Authors: Shara Nawar , Bjarnadottir Margret V. , Falah Noor , Chou Jiling , Alqutri Hasan S. , Asch Federico M. , Anderson Kelley M. , Bennett Sonita S. , Kuhn Alexander , Montalvo Becky , Sanchez Osirelis , Loveland Amy , Mohammed Selma F.
Published: May 2022

Background

Heart failure (HF) is a serious health condition, associated with high health care costs, and poor outcomes. Patient empowerment and self-care are a key component of successful HF management. The emergence of telehealth may enable providers to remotely monitor patients’ statuses, support adherence to medical guidelines, improve patient wellbeing, and promote daily awareness of overall patients’ health.

Objective

To assess the feasibility of a voice activated technology for monitoring of HF patients, and its impact on HF clinical outcomes and health care utilization.

Methods

We conducted a randomized clinical trial; ambulatory HF patients were randomized to voice activated technology or standard of care (SOC) for 90 days. The system developed for this study monitored patient symptoms using a daily survey and alerted healthcare providers of pre-determined reported symptoms of worsening HF. We used summary statistics and descriptive visualizations to study the alerts generated by the technology and to healthcare utilization outcomes.

Results

The average age of patients was 54 years, the majority were Black and 45% were women. Almost all participants had an annual income below $50,000. Baseline characteristics were not statistically significantly different between the two arms. The technical infrastructure was successfully set up and two thirds of the invited study participants interacted with the technology. Patients reported favorable perception and high comfort level with the use of voice activated technology. The responses from the participants varied widely and higher perceived symptom burden was not associated with hospitalization on qualitative assessment of the data visualization plot. Among patients randomized to the voice activated technology arm, there was one HF emergency department (ED) visit and 2 HF hospitalizations; there were no events in the SOC arm.

Conclusions

This study demonstrates the feasibility of remote symptom monitoring of HF patients using voice activated technology. The varying HF severity and the wide range of patient responses to the technology indicate that personalized technological approaches are needed to capture the full benefit of the technology. The differences in health care utilization between the two arms call for further study into the impact of remote monitoring on health care utilization and patients’ wellbeing.
Becoming metrics literate: An analysis of brief videos that teach about the h-index
Authors: Maggio Lauren A. , Jeffrey Alyssa , Haustein Stefanie , Samuel Anita
Published: May 2022

Introduction

Academia uses scholarly metrics, such as the h-index, to make hiring, promotion, and funding decisions. These high-stakes decisions require that those using scholarly metrics be able to recognize, interpret, critically assess and effectively and ethically use them. This study aimed to characterize educational videos about the h-index to understand available resources and provide recommendations for future educational initiatives.

Methods

The authors analyzed videos on the h-index posted to YouTube. Videos were identified by searching YouTube and were screened by two authors. To code the videos the authors created a coding sheet, which assessed content and presentation style with a focus on the videos’ educational quality based on Cognitive Load Theory. Two authors coded each video independently with discrepancies resolved by group consensus.

Results

Thirty-one videos met inclusion criteria. Twenty-one videos (68%) were screencasts and seven used a “talking head” approach. Twenty-six videos defined the h-index (83%) and provided examples of how to calculate and find it. The importance of the h-index in high-stakes decisions was raised in 14 (45%) videos. Sixteen videos (52%) described caveats about using the h-index, with potential disadvantages to early researchers the most prevalent (n = 7; 23%). All videos incorporated various educational approaches with potential impact on viewer cognitive load. A minority of videos (n = 10; 32%) displayed professional production quality.

Discussion

The videos featured content with potential to enhance viewers’ metrics literacies such that many defined the h-index and described its calculation, providing viewers with skills to recognize and interpret the metric. However, less than half described the h-index as an author quality indicator, which has been contested, and caveats about h-index use were inconsistently presented, suggesting room for improvement. While most videos integrated practices to facilitate balancing viewers’ cognitive load, few (32%) were of professional production quality. Some videos missed opportunities to adopt particular practices that could benefit learning.
Using molecular network analysis to explore the characteristics of HIV-1 transmission in a China-Myanmar border area
Authors: Zhang Yuying , Dai Jie , Li Zhengxu , Ma Yanling , Chen Huichao , Dong Lijuan , Jin Xiaomei , Yang Min , Zeng Zhijun , Sun Pengyan , Hu Anyan , Chen Min
Published: May 2022

Background

The China-Myanmar border area is considered a hot spot of active HIV-1 recombination in Southeast Asia. To better understand the characteristics of HIV-1 transmission in this area, a cross-sectional HIV-1 molecular epidemiological survey was conducted in Baoshan Prefecture of Yunnan Province.

Methods

In total, 708 newly reported HIV-1 cases in Baoshan Prefecture from 2019 to 2020 were included in this study. HIV-1 gag, pol and env genes were sequenced, and the spatial and demographic distributions of HIV-1 genotypes were analyzed. The characteristics of HIV-1 transmission were investigated using the HIV-1 molecular network method.

Results

In the 497 samples with genotyping results, 19 HIV-1 genotypes were found, with URFs being the predominant strains (30.2%, 150/497). The main circulating HIV-1 strains were mostly distributed in the northern area of Baoshan. URFs were more likely identified in Burmese individuals, intravenous drug users and those younger than 50 years old. CRF08_BC was more likely detected in farmers and those of Han ethnicity, CRF01_AE in the young and those of Han ethnicity, and CRF07_BC in the subpopulation with junior middle school education and higher. Moreover, CRF118_BC and CRF64_BC were more likely found in the subpopulation aged ≥40 years and ≥50 years, respectively. Among 480 individuals with pol sequence detection, 179 (37.3%) were grouped into 78 clusters, with Baoshan natives being more likely to be in the network. The proportion of the linked individuals showed significant differences when stratified by the regional origin, marital status, age and county of case reporting. In the molecular network, recent infections were more likely to occur among nonfarmers and individuals aged below 30 years.

Conclusions

HIV-1 genetics has become complex in Baoshan. HIV-1 molecular network analysis provided transmission characteristics in the local area, and these findings provided information to prioritize transmission-reduction interventions.
Asymptotic behavior of solutions to the multidimensional semidiscrete diffusion equation
Authors: Slavík Antonin
Published: May 2022

We study the asymptotic behavior of solutions to the multidimensional diffusion (heat) equation with continuous time and discrete space. We focus on initial-value problems with bounded initial data, and provide sufficient conditions for the existence of pointwise and uniform limits of solutions.
Aquatic Macroinvertebrates as Bio-indicators for the Assessment of Water Quality of the Vaughan Pond, Ghana
Authors: Hotor Prince , Atsu Dzidzornu Kwaku
Published: May 2022

The study was conducted to assess the water quality of the Vaughan Pond using the Hilsenhoff's Family Biotic Index (FBI) from February to April 2019 at (6) sampling stations. Physiochemical parameters were measured at the six stations. Macroinvertebrates were sampled using a 500Î¼m mesh size net. Altogether, 864 individuals from 38 families and 13 Orders were sampled.
Celebraciones centenarias. La construcción de una memoria nacional.
Authors: D'Amato Castillo Guissepe
Published: May 2022

Reseña del libro "Celebraciones centenarias. La construcción de una memoria nacional" escrito pro Raúl Román Romero.
Escoceses en Barranquilla
Authors: González Malabet María Auxiliadora
Published: May 2022

Migración escosesa a Barranquilla siglo XX.
Elise o Reclús a su paso por Barranquilla en 1855
Authors: Vidal Ortega Antonino
Published: May 2022

Memorias viajeras de Eliseo Reclús a su paso por Barranquilla
Analysis and Impact of Online Celebrity Brand Equity on Purchase Intention of Fans on Social Media
Authors: Utomo Mohammad Burhan , Hidayat Anas
Published: May 2022

This research aims to determine the impact of online celebrity brand equity on  purchase intention of fans on social media. The testing used 250 respondents. The sampling technique used purposive sampling. This research used Structural Equation Modeling (SEM) Analysis tool which was developed to test research hypotheses which was processed by using AMOS version 24. The variables used in this research were brand awareness, brand image, brand loyalty, purchase intention, and perceived quality. The results of the analysis indicated that brand awareness had positive and significant effect on brand image, brand awareness had positive and significant effect on brand loyalty, brand image had positive and significant effect on brand loyalty, brand loyalty had positive and significant effect on purchase intention, brand loyalty that supported purchase intention will be stronger with perceived quality.
Bestandsentwicklung in der Webarchivierung – Einsatzmöglichkeiten für Methoden der Digital Humanities
Authors: Schmid Katharina , Schoger Astrid , Weimer Konstanze
Published: May 2022

Die Auswahl archivwürdiger Websites für kuratierte Webarchivsammlungen ist ein ressourcenintensiver Prozess. Methoden der Digital Humanities, insbesondere der Text- und Linkanalyse, können gewinnbringend zur Unterstützung der Bestandsentwicklung in der selektiven Webarchivierung angewendet werden. In diesem Beitrag wird ein im Rahmen eines DFG-Projekts entwickeltes und an der Bayerischen Staatsbibliothek prototypisch umgesetztes Verfahren vorgestellt. Die Möglichkeiten und Herausforderungen des Einsatzes computergestützter Methoden beim Bestandsausbau in der Webarchivierung werden bewertet.
Quality changes of repeatedly fried palm oil and extracted oil from fried loach
Authors: Zheng Jie , Long Yuanyuan , Chen Wen , Zhi Wenli , Xu Tingting , Wang Lin , Hu Aijun
Published: May 2022

Fried loach is a kind of popular flavor food. The effects of repeated frying on peroxide value (PV), acid value (AV), P-anisidine value (P-AV), total polar components (TPC) and free fatty acids (FFA) of palm oil and extracted oil from fried loach (EOL) were studied. The loach was fried in palm oil at 170 °C for 3 min and the frying was repeated 10 times. The oil from fried loach was collected and analyzed. The results showed that the TPC of palm oil exceeded the standard limit (3 mg/g) when frying 10 times. The PV and TPC of EOL were unqualified after 9 and 4 times frying (19.17 meq O2/kg and 31% respectively). The AV of the EOL reached 2.46 mg/g after 9 times frying. Palm oil has better frying performance than EOL because of its balanced proportion of saturated and unsaturated fatty acids. Palm oil can be used for 9 times frying, while the EOL has been damaged after 4 times.
“A Triumph for Women” in Progressive Era Los Angeles: Socialist-Feminism, Coalition Building, and Independent Partisanship in the Political Career of Councilwoman Estelle Lawton Lindsey
Authors: Katz Sherry J.
Published: May 2022

In June 1915, socialist-feminist Estelle Lawton Lindsey became the first woman elected to the city council of a major metropolis in the United States. While Lindsey ran as a “woman’s candidate,” she won her seat on the Los Angeles City Council by constructing a broad and diverse electoral coalition. Although organized womanhood (largely white and middle class) constituted the heart of her coalition, she garnered significant backing from many reform constituencies, including trade unionists, socialists, progressive reformers, and African American community leaders. Lindsey turned coalition building into a successful electoral strategy for two major reasons. First, although Lindsey was a socialist, she ran for city council as an independent, adopting an independent partisanship, resting between the gendered political cultures of her day, that likely broadened her support among both female and male voters. Second, the structure of the city council election, in which candidates ran in a nonpartisan, at-large, and multimember district race, made the election of women like Lindsey possible in this period. Once elected, Lindsey championed measures tied to the goals of the electoral coalition that had embraced her candidacy and worked with coalition groups (especially women’s clubs) on specific policies. Despite robust support and collaboration for two years, Lindsey’s electoral coalition ultimately fragmented and doomed her reelection bid in 1917.
Skeletal muscle RUNX1 is related to insulin sensitivity through its effect on myogenic potential
Authors: Stefanowicz Magdalena , Nikołajuk Agnieszka , Matulewicz Natalia , Strączkowski Marek , Karczewska-Kupczewska Monika
Published: May 2022

Objective

Skeletal muscle is the major site of insulin action. There are limited data on the relationship between insulin action and skeletal muscle myogenic/regenerative potential. RUNX1 is a transcription factor which plays a role in muscle development and regeneration. The aim of our study was to assess the role of skeletal muscle myogenic/regenerative potential in the development of insulin resistance through the studies on RUNX1 transcription factor.

Design

This study is a cross-sectional study. Experimental part with myoblast cell line culture.

Methods

We examined 41 young healthy volunteers, 21 normal weight and 20 with overweight or obesity. Hyperinsulinemic-euglycemic clamp and vastus lateralis muscle biopsy were performed. In L6 myoblast and human skeletal muscle myoblasts (hSkMM) cell cultures, RUNX1 was silenced at two stages of development. Cell growth, the expression of markers of myogenesis, nuclei fusion index, Akt phosphorylation and glucose uptake were measured.

Results

Skeletal muscle RUNX1 expression was decreased in overweight/obese individuals in comparison with normal-weight individuals and was positively related to insulin sensitivity, independently of BMI. Runx1 loss-of-function at the stage of myoblast inhibited myoblast proliferation and differentiation and reduced insulin-stimulated Akt phosphorylation and insulin-stimulated glucose uptake. In contrast, Runx1 knockdown in myotubes did not affect Akt phosphorylation, glucose uptake and other parameters studied.

Conclusions

Myogenic/regenerative potential of adult skeletal muscle may be an important determinant of insulin action. Our data suggest that muscle RUNX1 may play a role in the modulation of insulin action through its effect on myogenesis.
Dose–exposure–IGF-I response of once-weekly somapacitan in adults with GH deficiency
Authors: Kildemoes Rasmus Juul , Hollensen Christian , Biller Beverly M K , Johannsson Gudmundur , Takahashi Yutaka , Rasmussen Michael Højby
Published: May 2022

Objective

Growth hormone (GH) replacement therapy in patients with adult growth hormone deficiency (AGHD) is individually titrated due to variable dose–responses among patients. The aim of this study was to provide clinical guidance on dosing and titration of the novel long-acting GH derivative somapacitan based on analyses of somapacitan dose–insulin-like growth factor I (IGF-I) responses in AGHD patients.

Design

Analyses of dosing information, 4364 somapacitan concentration samples and 4880 IGF-I samples from 330 AGHD patients treated with somapacitan in three phase 3 trials.

Methods

Pharmacokinetic/pharmacodynamic modelling was used to evaluate starting dose groups by age and oral oestrogen therapy, characterise the dose–IGF-I response in the overall AGHD population and patient subgroups, predict the IGF-I response to dose changes and simulate missed dosing.

Results

The analyses supported the clinical recommendations of higher starting doses for younger patients and women on oral oestrogen replacement therapy. For patients switching from daily GH treatment, the mean maintenance dose ratio between somapacitan (mg/week) and somatropin (mg/day) was predicted to be 8.2 (observed interquartile range of 6.7–9.1). Simulations of IGF-I SDS profiles confirmed the appropriate time for IGF-I sampling to be 3–4 days after somapacitan dosing and supported somapacitan administration with up to 3 days delay in case of missed dosing. Subgroup analyses characterised the dose–exposure–IGF-I response in patient subgroups and indicated that dose requirements are mainly influenced by sex and oral oestrogen treatment.

Conclusions

This study extends the knowledge of the somapacitan dose–IGF-I response and provides information on clinical dosing of once-weekly somapacitan in patients with AGHD.
Pancreatic neuroendocrine neoplasms: survival trend analysis of a comprehensive center
Authors: Coelho Sara , Costa Cláudia , Santos Ana Paula , Souteiro Pedro , Oliveira Joana , Oliveira Júlio , Azevedo Isabel , Torres Isabel , Bento Maria José
Published: May 2022

Objectives

Therapeutic options for pancreatic neuroendocrine neoplasia (Pan-NEN) have increased over the last decade. We aim to understand the evolution of the prognosis of patients with diagnosis of Pan-NEN within a 12-year period, considering the implementation of new treatments.

Methods

This study is a retrospective cohort study of patients diagnosed with Pan-NENs between 2006 and 2017. Survival outcome estimates were calculated by Kaplan–Meier method. The impact of baseline clinicopathological characteristics on survival was explored with the use of Cox proportional hazard model.

Results

Of the 97 patients, 77 (79.9%) had well-differentiated neuroendocrine tumor (NET) according to WHO 2010 classification, and 52 (53.6%) had localized or locoregional disease. There were no differences between clinicopathological characteristics and survival outcomes when comparing patients diagnosed between 2006–2011 and 2012–2017. Neuroendocrine carcinoma – HR 2.76, 95% CI 1.17–6.55 – and stages III and IV at diagnosis were independent poor prognostic factors – HR 6.02, 95% CI 2.22–16.33 and HR 6.93, 95% CI 2.94–16.32, respectively.

Conclusions

The new therapeutic approaches did not induce better survival outcomes on Pan-NEN in recent years. This is possibly due to the indolent nature of NET grades 1 and 2, even metastatic, allowing patients to be submitted to new target therapies along their disease course.
Endometriosis in transmasculine individuals
Authors: Ferrando Cecile A
Published: May 2022

Lay summary

Transmasculine people are assigned female at birth but identify as male. These patients often are prescribed testosterone therapy as part of their transition. This treatment can affect ovulation and stop menstrual periods. Endometriosis is a common condition that causes pelvic pain in some people born with female pelvic organs. Not a lot is known about transmasculine people and how often endometriosis affects them. Testosterone should help treat if not reduce the incidence of endometriosis. This commentary looks at the current literature in order to help clarify existing knowledge gaps. Transmasculine patients who present for hysterectomy as a surgery to help them affirm themselves in their self-identified gender sometimes report pelvic pain symptoms as well. There are many reasons why patients report pain before surgery, and this can be related to endometriosis, even though this diagnosis is less expected in this group. Providers caring for transmasculine patients should be aware of this.
КОНЦЕПТУАЛЬНЕ ОСМИСЛЕННЯ ОСОБЛИВОСТЕЙ УПРАВЛІННЯ ІННОВАЦІЙНИМ РОЗВИТКОМ ДЕРЖАВИ В СУЧАСНИХ УМОВАХ
Authors: Ситник Г. , Зубчик О. , Орел М.
Published: May 2022

Вступ. При вирішенні проблеми забезпечення інноваційного розвитку держави домінують фінансово-економічні та технологічні аспекти, а концептуальному осмисленню особливостей управління цим розвитком не надано належної уваги.Проблематика. Траєкторія інноваційного розвитку держав є турбулентною через нелінійну природу управління цим розвитком, тому концептуальне осмислення особливостей зазначеного управління є чинником ефективної інноваційної політики.Мета. Концептуальне осмислення особливостей управління інноваційним розвитком держави в сучасних умовахдержавотворення.Матеріали й методи. Аналітичний аналіз нормативних актів і наукових праць з використанням контент-аналізу,структурно-функціонального, системного, компаративного, абстрактно-логічного методів.Результати. Передумовою вирішення проблем інноваційного розвитку держави є запровадження підходу, який передбачає подолання її інституційної слабкості, враховує презумпцію нестабільності та невизначеності її буття. Запропоновано під цим розвитком розуміти впровадження нових політико-управлінських процесів, моделей і технологій, які забезпечують прийнятний рівень національної безпеки. Показано, що політичні технології можуть маніпулювати суспільною свідомістю при виборі пріоритетів вказаного розвитку, а його нелінійна динаміка зумовлює необхідність зміни цілей, методів і технологій в діяльності суб’єктів управління та забезпечення збалансованості між йогополітичною та адміністративною компонентами.Висновки. Стратегічним імперативом зменшення технологічних розривів між державами є врахування турбулентності траєкторії їхнього інноваційного розвитку, яка зумовлена нелінійною природою управління ним, тому інноваційна політика та механізми її імплементації мають враховувати нестійкість та невизначеність буття держави.
ПРОЦЕС ВАКУУМНОГО АКТИВОВАНОГО ДИФУЗІЙНОГО ХРОМУВАННЯ СТАЛЕЙ 15Х12ВНМФ і 20Х1М1Ф1ТР
Authors: Руденький Сергій , Карцев Микола , Корнєєв Олександр , Кунченко Олексій , Кунченко Юрій , Маринін Володимир , Коваленко Володимир , Бортницька Маргарита , Рижова Тетяна , Ляшенко Ігор , Мартиненко Людмила
Published: May 2022

Вступ. Сталі 15Х12ВНМФ і 20Х1М1Ф1ТР використовують в машинобудуванні як матеріал деталей турбін, для підвищення робочих температур яких необхідно поліпшити жаростійкість їхньої поверхні.Проблематика. Підвищення корозійної стійкості поверхні сталей можливо через нанесення захисного шару. Однозначно сказати, яке покриття й метод його формування на конкретній сталі забезпечить достатнє підвищення жаростійкості поверхні цього матеріалу, практично неможливо. Раніше сталі 15Х12ВНМФ і 20Х1М1Ф1ТР не захищали методом вакуумного хромування в парах хлористого натрію.Мета. Дослідити процес вакуумного активованого хромування сталей 15Х12ВНМФ і 20Х1М1Ф1ТР і його вплив на характеристики зразків з них.Матеріали й методи. Зразки для досліджень виготовляли зі сталей 15Х12ВНМФ і 20Х1М1Ф1ТР. Випробування на кавітаційне й абразивне зношування провадили на стендах, а на жаростійкість — в муфельній печі на повітрі. Для досліджень поверхні зразків використовували металографічні методи й рентгенофлуоресцентний аналіз (РФА).Результати. Зразки зі сталей15Х12ВНМФ і 20Х1М1Ф1ТР хромували методом вакуумного насичення в парах хлористого натрію при температурах 1070 і 1100 °С та тривалості процесу 4 і 10 год. Встановлено, що після хромування при кавітаційному і абразивному діянні зразки із цих сталей за зносостійкістю дещо поступаються вихідним зразкам. З’ясовано, що при хромуванні зразків на їхній поверхні утворюється дифузійний шар товщиною 50—130 мкм залежно від умов обробки. Вміст хрому в поверхневому шарі досліджуваних сталей змінюється, відповідно, в межах 56—82 ваг. % і 81—93 ваг. %, залежно від параметрів процесу насичення. Проведено порівняльні випробування цих зразків на жаростійкість на повітрі при температурі 900 °С. Встановлено, що жаростійкість хромованих зразків значно перевершує стійкість вихідних.Висновки. Дослідження процесу вакуумного активованого хромування зразків зі сталей 15Х12ВНМФ і 20Х1М1Ф1ТР показали, що така обробка значно підвищує жаростійкість цих матеріалів порівняно з вихідними.
Modelagem Matemática, BNCC e a prova do ENEM de 2019: confluências e reflexões
Authors: De Oliveira Lozada Claudia , De Oliveira Lozada Anneliese
Published: May 2022

Neste trabalho fazemos uma análise das questões da prova de Matemática e suas Tecnologias do Exame Nacional do Ensino Médio - ENEM 2019 que ensejam a modelagem matemática. Para tanto, tecemos considerações sobre as habilidades e competências previstas pela Base Nacional Comum Curricular e a Matriz de Referência do ENEM para verificar as confluências, assim como para uma melhor análise utilizamos a pesquisa qualitativa e classificamos as questões de acordo com uma tipologia, fornecendo deste modo parâmetros balizadores acerca das articulações dos conhecimentos para a resolução das questões.  Os resultados desta pesquisa demonstraram que há um quantitativo considerável de questões do ENEM 2019 que ensejam a modelagem matemática, sendo que houve uma preponderância do tipo 4, que são questões que podem ser resolvidas intuitivamente ou elaborando um modelo matemático, assim como uma prevalência do nível fácil nas questões analisadas e interdisciplinaridade com seis componentes curriculares da Educação Básica. Desta forma, trazemos uma nova reflexão sobre as modelagens matemáticas existentes, em especial, a modelagem matemática por meio de situações-problema e como o professor pode trabalhá-la nas aulas de Matemática, a partir de questões do ENEM.
Exploring the factors affecting pre-service science teachers’ actual use of technology during teaching practice
Authors: Habibi Akhmad , Razak Rafiza Abdul , Yusop Farrah Dina , Muhaimin Muhaimin , Asrial Asrial , Mukminin Amirul , Jamila Asih
Published: May 2022

The primary objective of the research reported on here was to decide whether a combined framework of the theory of planned behaviour (TPB) and technological pedagogical and content knowledge (TPACK) could be a valid and reliable model to predict Indonesian pre-service science teachers’ (PSTs’) actual use of technology (AUT) during teaching practice. A survey instrument consisting of attitudes (ATs), subjective norms (SN), perceived behavioural control (PBC), technological pedagogical knowledge (TPK), technological content knowledge (TCK), technological pedagogical content knowledge (TPCK), and AUT was adapted from previous studies and validated through face and content validity. Thereafter, the instrument was piloted to 135 PSTs and validated through exploratory factor analysis (EFA). The sample (n = 457) completed the instrument during the main data collection. The data analysis was done through the steps of partial least square structural equation modelling (PLS-SEM), t-test, and analysis of variance (ANOVA). Through the measurement model phase, the combined framework was reported to be reliable and valid. SN was the strongest predictor (β = .445) of AUT, followed by PBC (β = .281). Meanwhile, AT, TPK, TCK, and TPCK were reported to be insignificant. Additionally, significant differences regarding AUT were reported based on gender and institution. An insignificant relationship emerged based on information and communication technology (ICT) -based courses.
Development of mathematical model of P-102 waste heat boiler for modes of joint operation with GTU-6P gas turbine unit
Authors: Shelygin B.L. , Pankov S.A. , Gorshenin S.D. , Ledukhovsky G.V. , Kokulin l.A.
Published: May 2022

Application of the power plant based on GTU-6P gas turbine engine and P-102 waste heat boiler is a proven example of an effective technical solution to modernize existing industrial boiler houses and low-capacity combined heat and power plants. To improve the power plant, as well as to prove the effectiveness of its use under conditions of various power facilities, a mathematical model is needed. This model is the result of the synthesis of mathematical models of a gas turbine plant and a waste heat boiler. P-102 waste-heat boiler as an object of modeling has significant features, since it allows both autonomous operation and operation with the utilization of heat of GTU-6P flue gases. The purpose of this study is to develop a mathematical model of P-102 waste heat boiler for joint operation with GTU-6P in the adjustment range limits of loads. The mathematical model of the waste heat boiler is developed using the TRAKT software package. The development of a mathematical description for a rapid assessment of the plant efficiency indicators is carried out using the methods of regression analysis of data. The indicators of accuracy of the mathematical model are evaluated by comparison with experimental data. Experimental data is obtained under the operating conditions of the power plant of the type under consideration. The authors have developed a mathematical model of P-102 waste heat boiler in joint operation with GTU-6P gas turbine engine. The performance of the equipment is described with an accuracy acceptable for practical calculations. The mathematical model developed in the TRAKT software package makes it possible to solve the problems of mode optimization of a power plant. The calculation results obtained using this model differ from the operational data by an average of 2,2 %. The mathematical description for the rapid assessment of the plant efficiency indicators is characterized by the uncertainty of 6,3 %.
Improving the efficiency of emergency control systems for future-oriented connection of sources of distributed generation
Authors: Kondrashova Yu.N. , Gazizova O.V. , Malafeev A.V.
Published: May 2022

Improvement of energy-intensive technological processes of industrial enterprises requires increasing the reliability and efficiency of power supply of consumers. In this regard, one of the priority areas associated with introduction of the sources of distributed generation is mainstreamed in energy industry. This trend has both beneficial and negative impacts. It makes difficult to control normal, emergency, and post-emergency modes of power supply systems of enterprises of ferrous metallurgy. When new sources of distributed generation are introduced under the conditions of complex closed-loop power supply system, it is necessary to assess the level of short-circuit currents to check the electrical equipment and residual voltages across the busbars of the consumers of ferrous metallurgy. Also, it is necessary to determine the critical time of generators dropping and evaluate the stability in case of isolated operation. An algorithm has been developed for automated search of a dividing point in case of an emergency and isolated operation depending on the power balance to maintain stability. It is based on a combination of the method of successive network reduction and step-by-step method. To improve the reliability of essential consumers, the authors have developed an algorithm for automatic search for the dividing point during operation of emergency control system depending on the power balance to maintain stability. The authors have developed proprietary software to assess the effectiveness of emergency automation equipment of multi-level complex closed-loop power supply system of metallurgical enterprise. Performed calculations and analysis of emergency and post-emergency modes are designed to develop a comprehensive approach of a set of measures to ensure the reliability and stability of essential consumers in the mode of automatic search.
Primary Ewing sarcoma of the mesentery: An extremely uncommon case
Authors: S Patra , P Trivedi , BR Nagarjun
Published: May 2022

Ewing sarcoma usually arises in the bones of children. Extra-skeletal Ewing sarcoma commonly occurs in soft tissue and rarely involves other organs of the body. The mesentery besides the intestine is an extremely uncommon location. The diagnosis poses a challenge as other malignant small round cell tumors come in the differential diagnosis in this location. Early histopathological diagnosis and immunohistochemical confirmation are crucial to outline an appropriate treatment plan. Expression of membranous CD99 and nuclear FLI-1 and NKX2.2 are fairly specific for diagnosis. The molecular study is reserved for difficult cases. Prognosis is poor in an extra-skeletal location in older individuals.
Pre-treatment with lignocaine and ondansetron for prevention of pain on propofol injection: A prospective, double blinded, randomised comparative study
Authors: H Rayasam , RR Tumulu , PK Tumulu , T Garg
Published: May 2022

Background: Propofol is widely used for induction and maintenance of anaesthesia as well as for intensive care unit (ICU) sedation. One of its persistent side effects that still remains of concern today is the vascular pain associated with its injection. It causes significant distress to the patient and interfere with smooth induction of anaesthesia. Various pharmacological and nonpharmacological interventions have been done to eliminate pain on propofol injection (POPI). In this study we compared lignocaine and ondansetron in decreasing POPI during intravenous induction of anaesthesia. Material and methods: One hundred adult patients belonging to American society of Anaesthesiology (ASA) physical status I and II, scheduled for elective surgeries under general anaesthesia were selected and randomly allocated in to two groups. Group 1 received intravascular injection of lignocaine 0.1 mg/kg and Group 2 received injection ondansetron 0.1mg/kg as pre-treatment. A tourniquet was put before giving the pre-treatment followed by injection propofol for both the groups. Patients were assessed for pain during injection of propofol. Heart rate, blood pressure, and oxygen saturation were recorded at peri-induction and postoperatively. Results: The results showed no pain following propofol injection in 54% (Group 1, lignocaine group) and 60% (Group 2, ondansetron group); moderate pain in 10% in both the groups; severe pain in 2% (Group 1) and 6% (Group 2), of the patients. No significant haemodynamic changes were observed in both the groups. Conclusion: Pre-treatment with ondansetron is as effective as lignocaine in reducing POPI.
Cutaneous metastasis of invasive ductal carcinoma on FNAC: A case report
Authors: A Kaushik , U Joshi , P Pant , G Rizvi , HS Pandey
Published: May 2022

The cutaneous metastasis is a late uncommon manifestation of cancer and indicates poor prognosis. The cutaneous metastasis can be a first presentation of underlying malignancy. The FNAC is an easy tool for rapid diagnosis of cutaneous metastasis. A 47-year-old female, known case of invasive ductal carcinoma presented to hospital with history of multiple nodular skin lesions over the body varying in size from 0.5-1.5 cm from past 2 months. The smears were cellular and comprises of loose clusters and singly scattered atypical epithelial cells, displaying moderate degree of pleomorphism with mild amount of cytoplasm, large irregular nucleus with fine to coarse chromatin, inconspicuous to conspicuous nucleoli and occasional atypical mitosis against a lipohemorrhagic background. The diagnosis of metastatic deposits of invasive ductal carcinoma was rendered. The clinical diagnosis of metastatic deposits can be challenges, especially in case of distant metastasis or when the cutaneous metastasis is the first presentation. The cutaneous metastasis can be confused clinically as adnexal lesion. The use of special stains and immunohistochemical markers can aid in diagnosis.
Reseña: Ventura Franch, A. y Iglesias Bárez, M. (Coords.) (2020). Manual de Derecho Constitucional Español con Perspectiva de Género, Vol. I. (Ediciones Universidad de Salamanca)
Authors: Domínguez Miguel
Published: May 2022

Reseña académica al manual coordinado por las profesoras Asunción Ventura y Mercedes Iglesias y auspiciado bajo el amparo e impulso de la Red Feminista de Derecho Constitucional.
On Interests of Parties to Criminal Proceedings
Authors:   Senior Lecturer of the Department of Criminal Procedure of the Ekaterinburg Branch of the Moscow Academy of the Investigative Committee of the Russian Federation, Karkoshko Yury S.
Published: May 2022

In the article, the author attempts to generalize the existing points of view, analyze the provisions of the law and the examples available in law enforcement practice, to understand the content of the interests of participants in the criminal process.
Development of the acmeological potential of the future specialist in physical culture and sports
Authors: Dzhumabaevna Koldasbayeva Bagila , Bagdatovich Doshybekov Aydin , Tleshovich Zhetimekov Yerkin , Kadyrbekovich Nassiyev Yermek , Auelkhanovna Abdraimova Kulmeskhan , Uaidullakyzy Elmira
Published: May 2022

Abstract
The purpose of this research is to activate the potential of the future expert in physical culture and sports, to use it and to investigate the ways of self-development. The research was completed using the phenomenological design. The research was conducted with 50 physical education and sports teacher candidates attending the 1st and 4th grades in the 2021–2022 academic year. During the data collection process, a Semi-Structured Interview Form developed by the researchers and prepared by taking the opinions of three different field experts was applied. The answers were sought from the physical education and sports teacher candidates about their views on self-development, their views on the factors that hinder their self-development, their views on the institutions/organisations they benefited from while developing themselves and the development of their acmeological potential. Grouping method was used for data analysis and individual results were collected in different group environments. According to the results of the research, the situations that prevent the students from developing themselves and the data on the development of the acmeological potential were determined. It is thought that a similar study will contribute to the field.
Keywords: Acmeology, self-development, lifelong learning, physical education and sport.
MAPEAMENTO DOS PRODUTOS E SERVIÇOS TECNOLÓGICOS NA UNIVERSIDADE FEDERAL DO TOCANTINS – UFT
Authors: COSTA BEATRIZ BATISTA , ABREU SOUSA KLEBER
Published: May 2022

O objetivo desse trabalho foi fazer um mapeamento dos produtos e serviços tecnológicos desenvolvidos e ofertados pela Universidade Federal do Tocantins – UFT. Por meio da pesquisa exploratória, dentro da abordagem qualitativa, instrumentalizada por questionário semiestruturado e também pela análise de documentos foi possível mapear os produtos e serviços tecnológicos produzidos pela Universidade, e sua adesão ao perfil das indústrias do estado do estado do Tocantins. Dessa forma, como produtos tecnológicos, pôde- se mapear os registros de patentes e registros de software da Universidade como um todo. Em relação aos serviços tecnológicos, o mapeamento foi realizado nos laboratórios dos campus de Araguaína, Palmas e Gurupi. O estudo trouxe como resultados a constatação das áreas que mais apresentam patentes depositadas, sendo a indústria química, petroquímica e farmacêutica, indústria da construção civil e a indústria da alimentação. Entretanto, chama atenção o baixo nível de articulação entre os laboratórios e as empresas do estado, sendo necessária maior discussão acerca da interação U-E. Acredita-se que esse mapeamento possa ser um instrumento estratégico para auxiliar os gestores da área de inovação na tentativa de interação com o setor produtivo e também no desenvolvimento de políticas institucionais de empreendedorismo e inovação.