bluuebunny/crossref_metadata_2025 huggingface dataset:
KIFC1: A Reliable Prognostic Biomarker in Rb-positive Triple-negative Breast Cancer Patients Treated With Doxorubicin in Combination With Abemaciclib
Authors: FLEISHER BRETT , WERKMAN CAROLIN , JACOBS BREHANNA , VARKEY JUSTIN , TAHA KAREEM , AIT-OUDHIA SIHEM
Published: August 2022

Background/Aim: Triple-negative breast cancer (TNBC) prevalence and risk of relapse are greatest in African American (AA) patients. Doxorubicin (DOX) and abemaciclib (ABE) synergism in Rb-positive TNBC cells (MDA-MB-231), and antagonism in Rb-negative TNBC cells (MDA-MB-468) have been previously shown. Here, we assessed Kinesin-like protein 1 (KIFC1) as an ethnic-specific prognostic biomarker of the DOX+ABE combination for the Rb-status in TNBC. Materials and Methods: Literature search for TNBC prognostic biomarkers in the AA population was conducted. MDA-MB-231 and MDA-MB-468 cells were exposed over 72 h to four treatment arms: 1) control (medium without drug), 2) DOX at 50% inhibitory concentration in MDA-MB-231 (0.565 μM) and MDA-MB-468 (0.121 μM), 3) ABE alone (2 μM), and 4) DOX+ABE combination at their corresponding concentrations in each cell-line. KIFC1 protein expression and temporal changes were quantified in MDA-MB-231 cells using western blot. Results: KIFC1, Kaiso, and Annexin A2 are literature-identified AA-specific TNBC prognostic biomarkers. KIFC1 was found to be uncorrelated to other proposed biomarkers, suggesting it may predict risk independently of other TNBC biomarkers. In both cell lines, DOX alone did not significantly change KIFC1 expression relative to control. Conversely, ABE reduced KIFC1 expression in MDA-MB-231 but not in MDA-MB-468 cells. The combination DOX+ABE resulted in a greatest reduction in KIFC1 in MDA-MB-231 cells with a more rapid time-to-full inhibition of KIFC1 compared to ABE alone. Conclusion: Change in KIFC1 expression is primarily driven by ABE in Rb-positive TNBC cells. DOX increases ABE speed to achieve a full inhibition of KIFC1 in Rb-positive, yet, without influencing its expression in Rb-negative TNBC cells.
Effect of Bevacizumab on a Human Breast Cancer Model that Exhibited Palbociclib-resistance by RB Knockout
Authors: ISHIKURA NOBUYUKI , SUGIMOTO MASAMICHI , YOROZU KEIGO , KURASAWA MITSUE , WAKITA DAIKO , KONDOH OSAMU
Published: August 2022

Background/Aim: Although CDK4/6 inhibitors have been increasingly used in combination with hormonal agents to treat hormone-receptor positive and human epithelial growth factor receptor 2-negative breast cancer, the mechanism of CDK4/6 inhibitor resistance and its impact on established therapy for post-resistance, especially bevacizumab combined with chemotherapy, are unclear. Materials and Methods: Sensitivity of RB knockout MCF7 clones to CDK4/6 inhibitors was evaluated in vitro. One RB knockout clone was subcutaneously implanted in nude mice and the effects of bevacizumab on volume and microvessel density (MVD) of tumors were investigated. Results: Palbociclib did not exhibit antitumor efficacy against the RB knockout tumor, in contrast to the parental MCF7 xenograft model. Bevacizumab significantly exhibited antitumor efficacy and suppressed the MVD both in RB knockout and parental MCF7 xenograft models. Conclusion: Bevacizumab inhibited tumor growth by suppressing MVD in the CDK4/6 inhibitor-resistant tumor acquired due to RB loss, suggesting its efficacy also in patients after treatment with CDK4/6 inhibitors.
Variants in HOXB13, G132E and F127C, Are Associated With Prostate Cancer Risk in Japanese Men
Authors: KURIHARA SOTA , MATSUI HIROSHI , OHTAKE NOBUAKI , AOKI MASANORI , SEKINE YOSHITAKA , ARAI SEIJI , KOIKE HIDEKAZU , SUZUKI KAZUHIRO , MIYAZAWA YOSHIYUKI
Published: August 2022

Background/Aim: Several studies have reported on the relationship between HOXB13 variants and an increased prostate cancer (PC) risk. To our knowledge there are not many studies on HOXB13 mutations in Japanese patients with prostate cancer, and there many issues remain uninvestigated. We herein clarified the association between HOXB13 genetic variants and PC risk in a Japanese population. Patients and Methods: PC patients were diagnosed at the Gunma University Hospital and affiliated hospitals from 1994 to 2016. Sanger sequencing was performed on the coding regions of the HOXB13 gene in 152 familial PC (FPC) patients. Genotyping was performed on single nucleotide variants (SNVs) found in Sanger sequencing in 230 FPC patients from 152 pedigrees and 197 sporadic PC (SPC) patients and 144 controls. Allelic frequency and clinical data for each variant were studied in cases and controls. Results: G132E and F127C were identified in FPC patients. The frequencies of G132E and F127C were significantly higher compared to the control group (p=0.039). In three families, seven PC patients shared the G132E variant, within second-to-third-degree relatives. It was not possible to clarify to pathogenicity of each SNV alone. Conclusion: We found two significant variants of the HOXB13 gene, G132E, F127C by analyzing and comparing gene samples from PC and non-PC patients. Furthermore, the HOXB13 G132E variant was found significantly increased in the FPC group.
Endometrial Cancer Incidence in Patients With Atypical Endometrial Hyperplasia According to Mode of Management
Authors: BARAKAT ANAS , ISMAIL AEMN , CHATTOPADHYAY SUPRATIK , DAVIES QUENTIN
Published: August 2022

Background/Aim: It is well established that around one-third of patients with atypical endometrial hyperplasia (AEH) go on to develop endometrial cancer (EC). Patients and Methods: This retrospective cohort study included 119 patients recruited from the University Hospitals of Leicester from 01/01/2015 to 01/01/2020 with a diagnosis of AEH by endometrial biopsy. Patients were divided into two groups according to the management modality: Primary surgery (n=99), and conservative treatment (n=20). The aim of this study was to determine the incidence of EC in patients with AEH in University Hospitals of Leicester, UK, and to explore the reasons why patients with AEH opted for conservative management. Results: EC was diagnosed in 34.4% of patients with AEH managed by primary surgery. Moreover, the incidence of EC in patients with AEH managed conservatively was 25%. The main reason for opting for conservative management was that patients were unfit for surgery when assessed in the high-risk Anaesthetic Clinic (35%). Conclusion: AEH is a pre-malignant lesion that has high risk of EC regardless of the mode of management. Total hysterectomy is the safest first line of treatment in AEH due to the high risk of concurrent EC and progression to EC. Currently, there is no reliable follow-up intervention to distinguish between concurrent EC and progression of AEH. Adequate discussion and counselling are essential when discussing conservative management for women with complex AEH. Patients should be counselled regarding the high risk of developing concurrent EC and risk of progression to EC.
Effect of Applying a Real-Time Medical Record Input Assistance System With Voice Artificial Intelligence on Triage Task Performance in the Emergency Department: Prospective Interventional Study
Authors: Cho Ara , Min In Kyung , Hong Seungkyun , Chung Hyun Soo , Lee Hyun Sim , Kim Ji Hoon
Published: August 2022

Background

Natural language processing has been established as an important tool when using unstructured text data; however, most studies in the medical field have been limited to a retrospective analysis of text entered manually by humans. Little research has focused on applying natural language processing to the conversion of raw voice data generated in the clinical field into text using speech-to-text algorithms.

Objective

In this study, we investigated the promptness and reliability of a real-time medical record input assistance system with voice artificial intelligence (RMIS-AI) and compared it to the manual method for triage tasks in the emergency department.

Methods

From June 4, 2021, to September 12, 2021, RMIS-AI, using a machine learning engine trained with 1717 triage cases over 6 months, was prospectively applied in clinical practice in a triage unit. We analyzed a total of 1063 triage tasks performed by 19 triage nurses who agreed to participate. The primary outcome was the time for participants to perform the triage task.

Results

The median time for participants to perform the triage task was 204 (IQR 155, 277) seconds by RMIS-AI and 231 (IQR 180, 313) seconds using manual method; this difference was statistically significant (P<.001). Most variables required for entry in the triage note showed a higher record completion rate by the manual method, but in the recording of additional chief concerns and past medical history, RMIS-AI showed a higher record completion rate than the manual method. Categorical variables entered by RMIS-AI showed less accuracy compared with continuous variables, such as vital signs.

Conclusions

RMIS-AI improves the promptness in performing triage tasks as compared to using the manual input method. However, to make it a reliable alternative to the conventional method, technical supplementation and additional research should be pursued.
Using Normative Language When Describing Scientific Findings: Protocol for a Randomized Controlled Trial of Effects on Trust and Credibility
Authors: Agley Jon , Xiao Yunyu , Thompson Esi E , Golzarri-Arroyo Lilian
Published: August 2022

Background

Trust in science and scientists has received renewed attention because of the “infodemic” occurring alongside COVID-19. A robust evidence basis shows that such trust is associated with belief in misinformation and willingness to engage in public and personal health behaviors. At the same time, trust and the associated construct of credibility are complex meta-cognitive concepts that often are oversimplified in quantitative research. The discussion of research often includes both normative language (what one ought to do based on a study’s findings) and cognitive language (what a study found), but these types of claims are very different, since normative claims make assumptions about people’s interests. Thus, this paper presents a protocol for a large randomized controlled trial to experimentally test whether some of the variability in trust in science and scientists and perceived message credibility is attributable to the use of normative language when sharing study findings in contrast to the use of cognitive language alone.

Objective

The objective of this trial will be to examine if reading normative and cognitive claims about a scientific study, compared to cognitive claims alone, results in lower trust in science and scientists as well as lower perceived credibility of the scientist who conducted the study, perceived credibility of the research, trust in the scientific information on the post, and trust in scientific information coming from the author of the post.

Methods

We will conduct a randomized controlled trial consisting of 2 parallel groups and a 1:1 allocation ratio. A sample of 1500 adults aged ≥18 years who represent the overall US population distribution by gender, race/ethnicity, and age will randomly be assigned to either an “intervention” arm (normative and cognitive claims) or a control arm (cognitive claims alone). In each arm, participants will view and verify their understanding of an ecologically valid claim or set of claims (ie, from a highly cited, published research study) designed to look like a social media post. Outcomes will be trust in science and scientists, the perceived credibility of the scientist who conducted the study, the perceived credibility of the research, trust in the scientific information on the post, and trust in scientific information coming from the author of the post. Analyses will incorporate 9 covariates.

Results

This study will be conducted without using any external funding mechanisms.

Conclusions

If there is a measurable effect attributable to the inclusion of normative language when writing about scientific findings, it should generate discussion about how such findings are presented and disseminated.

Trial Registration

Open Science Framework n7yfc; https://osf.io/n7yfc

International Registered Report Identifier (IRRID)

PRR1-10.2196/41747
ORTA KADEME YÖNETİCİLERİNİN STRATEJİK DAVRANIŞLARI ÜZERİNE İŞ DOYUMU VE DUYGUSAL BAĞLILIĞIN ETKİSİ
Authors: TÜRKAY Oğuz , ATASOY Burak
Published: August 2022

Amaç: Orta kademe yöneticilerin stratejik davranışları, üstlerine ve astlarına yönelik sergilenen ve aslında işletmenin en üst karar otoritesiyle en alt uygulama birimini birbirine bağlayan kritik bir dizi davranış kalıbını kapsamaktadır. Bu araştırmanın amacı, orta kademe yöneticilerin sergilemeleri beklenen bu davranışların ortaya çıkmasında onların iş doyumu ve duygusal bağlılıklarının etkilerini belirlemektir. Yöntem: Araştırmanın çalışma evreni İstanbul’da yer alan (S class, 2 ve 3*, 4*, 5*) konaklama işletmelerinin orta kademe yöneticileridir. 2017 yılında kolayda örneklem tekniğinden yararlanılarak 391 katılımcıdan veri elde edilmiştir. Verilerin analizi sürecinde SPSS Amos yazılımından yararlanılmıştır.Bulgular: Konaklama işletmelerinde çalışan orta kademe yöneticilerin ast ve üstlerine yönelik stratejik davranışlarında iş doyumu ve duygusal bağlılıklarının etkisi olduğu tespit edilmiştir. Sonuç: Konaklama işletmelerinde orta kademe yöneticiler, misafirler ile doğrudan temas halinde olma yanında, astlardan aldıkları bilgiyi tepe yönetime ulaştırma, üst yönetimin politikalarının astlarca benimsenmesini sağlama ve uygulamaların da üst yönetim adına denetimini yapma gibi stratejik roller üstlenmektedir. Orta kademe yöneticilerin görevlerini icra ederken, iş koşullarının tatmin edici olmasının kuruma olan bağlılığını arttırdığı sonucuna ulaşılmıştır. Yöneticilerin yüksek iş doyumu ve kurumsal bağlılığının ast ve üstlere yönelik davranışlarını açıkladığı görülmüştür. Otel işletmelerinin örgütsel hedeflerine erişmesi açısından orta kademe yöneticilerini desteklenmesi, iş doyumu ve duygusal bağlılıklarını artıracak çözümler geliştirmesi ve bu yöneticilere bu kapsamda çeşitli olanakların sağlanması önemli görülmektedir.
Continuous Glucose Monitoring to Optimize Management of Diabetes in Patients with Advanced CKD
Authors: Galindo Rodolfo J. , de Boer Ian H. , Neumiller Joshua J. , Tuttle Katherine R.
Published: August 2022

Treatment of patients with diabetes and CKD includes optimizing glycemic control using lifestyle modifications and drugs that safely control glycemia and improve clinical kidney and cardiovascular disease outcomes. However, patients with advanced CKD, defined as eGFR <30 ml/min per 1.73 m2 or kidney disease treated with dialysis, have limitations to the use of some preferred glucose-lowering medications, are often treated with insulin, and experience high rates of severe hypoglycemia. Moreover, hemoglobin A1c accuracy decreases as GFR deteriorates. Hence, there is a need for better glycemic monitoring tools. Continuous glucose monitoring allows for 24-hour glycemic monitoring to understand patterns and the effects of lifestyle and medications. Real-time continuous glucose monitoring can be used to guide the administration of insulin and noninsulin therapies. Continuous glucose monitoring can overcome the limitations of self-monitored capillary glucose testing and hemoglobin A1c and has been shown to prevent hypoglycemic excursions in some populations. More data are needed to understand whether similar benefits can be obtained for patients with diabetes and advanced CKD. This review provides an updated approach to management of glycemia in advanced CKD, focusing on the role of continuous glucose monitoring in this high-risk population.
Quorum Quenching Potential of Biogenic Silver Nanoparticles against Chromobacterium violaceum 4212
Authors: Anju S. , Sarada J.
Published: August 2022

The Chromobacterium violaceum is a gram-negative facultative anaerobic bacterium that is known to cause human infections in lungs, liver, brain, spleen lymph nodes and urinary tract. It has Acyl Homoserine Lactone (AHL) regulated virulence features like violacein pigment production, swarming motility, biofilm formation and haemolysis. Bacterial pathogens form biofilms in natural as well as medical implants due to a complex signalling – “Quorum Sensing” (QS). QS builds an interaction among the cells, which increases the proliferation and mechanisms necessary for invasion into the host. Instead of using only bactericidal agents for infection control, suppression of QS by Quorum Quenching agents (QQ) can overcome limitations of currently used antimicrobial substances. In the present study biogenic silver nanoparticles (BSNPs) synthesized from selected five plant extracts were screened against Chromobacterium violaceum MCC 4212 for QQ potential. Biofilm inhibition of 91.8% and dispersal of 81.33% was found to be exhibited by BSNPsmade from extracts of Garcinia and Trachyspermum. Swarming nature was inhibited by 66% while there was complete inhibition of haemolysis by BSNPs. Therefore, the BSNPs synthesized were found potential to control the pathogenicity of C. violaceum 4212 as an antibiofilm agent.
A Modified Maximum Power Point Tracking with Constant Power Generation Using Adaptive Neuro-Fuzzy Inference System Algorithm
Authors: Sudiharto Indhana , Prasetyono Eka , Budikarso Anang , FitriaDevi Safira
Published: August 2022

Renewable energy is being used to lessen the consumption of fossil fuels. Solar energy is a common source of renewable energy. Solar energy is the most promising source of energy due to its long-term sustainability and availability. The output power of solar panels is strongly influenced by the intensity of sunlight and the temperature of the solar panels. Maximum Power Point Tracking (MPPT) control, which aims to optimize the output power of solar panels, is commonly used to increase the efficiency of solar panels. However, MPPT control often causes overvoltage disturbance in systems directly connected to the load. To limit the output power of solar panels, additional Constant Power Generation (CPG) control is required. In this research, a solar panel system will be created to supply submersible DC pumps without any energy storage devices. DC-DC SEPIC Converter is designed with MPPT control combined with CPG control to limit the output power of the converter using the Adaptive Neuro-Fuzzy Inference System method by 150 watts. When the output power of the solar panel is less than the power limit, then MPPT mode will work. While CPG mode works when the PV output power is greater than the limit power. The results of this research showed that the system can provide optimal power generated by solar panels in MPPT mode by increasing efficiency by up to 33.04% and CPG mode can limit power to 150 Watts to avoid overvoltage disturbance at load.
Light-Fidelity as Next Generation Network Technology: A Bibliometric Survey and Analysis
Authors: Safitri Cutifa , Galina Mia , Simatupang Joni Welman
Published: August 2022

This paper delivers a systematic review and a bibliometric survey analysis of Light-Fidelity (Li-Fi) indoor implementation in Next Generation Network (NGN). The main objective of this study is to design a communication network based on NGN-Li-Fi for the indoor implementation which aims to increase user Quality of Service (QoS). The main merits and contributions of this study are the thorough and detailed analysis of the review, both in literature surveys and bibliometric analysis, as well as the discussion of the implementation model challenges of Li-Fi in both indoor and outdoor environments. The issue articulated in an indoor communication network is the possibility of intermittent connectivity due to barriers caused by line-of-sight (LOS) between the LED transmitter and receiver, handover due to channel overlap, and other network reliability issues. To realize the full potential and significant benefits of the Next Generation Network, challenges in indoor communication such as load-balancing and anticipating network congestion (traffic congestion) must be addressed. The main benefit of this study is the in-depth investigation of surveys in both selected critical literatures and bibliometric approach. This study seeks to comprehend the implications of Next Generation networks for indoor communication networks, particularly for visible light communication channels.
The survey of Chinese parents' awareness of the characteristics and identification of the gifted and the gifted education
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yoo Minhee , Zhu Shu Hui , Lee Shin-dong
Published: August 2022

Objectives The purpose of this study is to provide basic data and implications for gifted education in China by identifying the degree of awareness of Chinese parents about the characteristics of gifted children, gifted children indentify, gifted education according to the general characteristics of parents. Methods To this end, ‘wenjuanxing’ (https://www.wjxcn/jq/101862383.aspx) surveyed 1,028 parents of Foreign Language School A in Anqing City, Anhui Province and School B in Wufu City, Anhui Province. For the collected data, percentage and frequency analysis was performed on the general characteristics of Chinese parents, and a chi-square test was performed to analyze the results of Chinese parents' perceptions of gifted characteristics and giftedness identify and gifted education according to general characteristics. Results The results of this study are comprehensively summarized as follows. First, in Chinese parents' perceptions of giftedness, parents recognized ‘children with excellent academic performance and high intelligence’ as gifted, and viewed ‘high intelligence’ as the greatest characteristic of gifted children. And area of gifted children, the highest question was about ‘what characteristics gifted children exhibit’, and they recognized that ‘both genetic and environmental factors are important’ in order to develop giftedness. Second, regarding the identification of gifted children, it was recognized that ‘3 - 5 years old’ was the most appropriate time to identify gifted children. Lastly, in the perception of gifted education, fathers and mothers agreed on the perception that gifted education is ‘education to cultivate creative thinkers’, but they showed a difference of opinion on the necessity of gifted education. As for the reason why it was necessary, it was confirmed that there was a common view that ‘Gift education is necessary for the development of potential’, but opinions differed as to the reason why it was not necessary. In addition, 86.6% of the survey subjects expressed their intention to participate in parenting education in order to make their children gifted, but the reason why they would receive parental education was had different opinions. Conclusions Chinese parents did not have a diverse understanding of gifted children and gifted education. To this end, there is a need to manage important issues such as public education and national standards for gifted education and establishment of an education system.
A Study of College English Reading Class Teaching Method: Focusing on Cooperative Learning
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yeo Sooyeon
Published: August 2022

Objectives The purpose of this study is to investigate the effectiveness of cooperative learning in university English reading classes: how it affects students' learning motivation, class satisfaction, and academic achievement. Methods For the purpose, this study conducted an experimental study on a total of 70 college students for 10 weeks. Thirty-four of them took the English reading classes using cooperative learning as an experimental group. The other thirty-six took the English reading classes in a traditional way. For the study, data were collected from each group and their responses were analyzed through statistics. Results The experimental class showed that intrinsic motivation, class satisfaction, and academic achievement were statistically significant. As a result of analyzing each sub-factor of class satisfaction, among the four factors, the interest, suitability, and satisfaction showed significant differences. Also, in the experimental class, it had a statistically significant effect on academic achievement in the final exam. Conclusions These results show that cooperative learning in college English reading classes has a significant influence on learners' learning motivation, class satisfaction, and learning achievement. These findings can help improve teachers' teaching styles by applying cooperative learning effectively in English learning.
The Effects of Parental resilience and Family Strength on Young Children's Social Competence
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Sung Suk
Published: August 2022

Objectives This study was conducted to analyze how the parental resilience and family strength of the parents influences children’s social competence. Methods For this study, 215 young children at an age of 4~5 were surveyed on parental resilience, family strength and social competence. Results According to the results of this study, there was a correlation between parental resilience and the children’s social Competence. In addition, regression analysis on this subject showed that parental resilience had meaningful effects on the children’s social Competence. Second, family strength had a relevant correlation with children’s social competence and further regression analysis on this subject showed that family strength gave a relevant explanation of children’s social competence. In other words, it was confirmed that family strength had relevant effects on children’s social competence. Conclusions Based on these results, it can be affirmed that to enhance children’s social competence, the pursuit of parental resilience and family strength should be accompanied.
Development of Blended Learning Instruction Materials in NCS-based Home Appliance Hardware Development Subject
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Choi Hyo-Sun , Yoo Hyun-Seok
Published: August 2022

Objectives The purpose of this study is to develop blended learning instruction materials for ‘Detailed circuit diagram drawing’ section using Google Classroom in the NCS-based home appliance hardware development subject, and to investigate the effect on the academic achievement of specialized high school students. Methods In this study, the development direction and learning goals of class materials were set through the analysis of curriculum, job duties, and learners, and a plan for using Google Classroom was devised. Instruction materials that can be applied to specialized high school practical classes were developed, Based on the NCS learning module, this class material presented practical information, relational knowledge, design drawings, and self-checklist, and was developed to enable learners to learn by level and self-directed learning. In this study, academic achievement was evaluated by applying the heterogeneous control group after test to two classes of technical high schools. Results As a result of analyzing the effect of the instructional materials developed in this study on academic achievement, there was a significant improvement in academic achievement only in the subgroup in the cognitive domain. On the other hand, in the psychodynamic domain, the academic achievement of the median and subgroups improved, and in the affective domain, there was a significant effect on the students in the middle group. In all areas of academic achievement, there was no significant effect for the students in the upper group. Conclusions The blended learning instructional material developed in this study ‘Create a detailed circuit diagram’ is more effective for the middle-class and lower-class students in terms of academic achievement compared to the traditional instruction-oriented classes.
Conocimientos y actitudes sobre interrupción voluntaria del embarazo en estudiantes de una Universidad de Cartagena (Colombia)
Authors: Saldarriaga-Genes Guillermina , Ruidiaz-Gómez Keidis Sulay , Cortés-Marchán María Margarita , Guerrero-Martínez Daniela , Salas-Diaz Erika Isabel , Hernández-Bello Ladini
Published: August 2022

Introducción: La interrupción voluntaria del embarazo es un asunto político que polariza las opiniones y genera controversias entre el sector salud, social, económico y cultural. Objetivo: Determinar el nivel de conocimiento y actitudes sobre la interrupción voluntaria del embarazo en estudiantes de dos programas de Ciencias de la Salud de Cartagena. Materiales y métodos: Estudio descriptivo transversal, se aplicó el cuestionario adaptado por Marceliano y Medrano a 231 estudiantes de Enfermería y Medicina, los datos se analizaron obteniendo frecuencias relativas y absolutas. Resultados: El nivel de conocimiento de los estudiantes fue alto con 92,20% (213). Sin embargo, el 37,2% (86) no sabía cuáles eran las tres causales para que el aborto no se considere un delito. El 56,7% asume actitudes negativas hacia firmar una petición para legalizar el aborto y el 18,8% considera que si una mujer se realiza un aborto debe ir a la cárcel. Conclusión: El nivel de conocimiento de los estudiantes de medicina y enfermería es alto, sin embargo, los patrones muestran desconocimiento sobre las causales de legalización del aborto de acuerdo con la norma vigente y una variabilidad de actitudes positivas y negativas ante la interrupción voluntaria del embarazo.
Quinta arremetida de COVID-19 y el uso de mascarillas en espacios abiertos y cerrados
Authors: Fuertes-Bucheli José Fernando , Peláez-Martínez Juan David , Martínez-Niño María del Mar , Aguilar-Gonzalez Ana María , Dorris Madeline , Ferro Beatriz E. , Pacheco Robinson
Published: August 2022

Introducción: La pandemia COVID-19 demanda permanentes adaptaciones en la gestión según la situación epidemiológica.  Objetivo: Analizar el comportamiento epidemiológico de COVID-19 en Cali (Colombia) post levantamiento de obligatoriedad de usar mascarillas en ambientes abiertos y cerrados, entre marzo 1 y julio 11 de 2022. Materiales y métodos: Estudio observacional descriptivo de casos de COVID-19 e incidencia acumulada (IA) para 7 días, con dos hitos temporales: desistimiento del uso mandatorio de mascarillas en ambientes abiertos y cerrados, usando datos publicados por el Instituto Nacional de Salud. Se evaluó la tendencia temporal con la prueba no paramétrica Mann-Kendall. Resultados: Se demostraron diferencias entre el primer y segundo hito: 922 casos en 75 días versus 12.037 en 59 días; Tau=-0,22 versus 0,57, S=-608 versus 968, Var(S)=47.574,66 versus 233.280,66; pendiente de Sen=-0,10 (IC95%: -0,18 y -0,03) versus 7,39 (IC95%: 5,23 y 8,88). Luego del segundo hito, la IA aumentó con tendencia positiva (S=23, p=0,006). Conclusiones: El aumento significativo de casos de COVID-19 y de IA coincidió con el levantamiento de la medida de usar mascarillas en espacios cerrados. Por tanto, se apoya el regresar al uso de mascarillas en espacios cerrados, reforzar la gestión infodémica, promover la vacunación y acrecentar la ventilación natural.
Genetic profile and characteristics of HIV-1 drug resistance mutation in the Krasnodar region over the 2014 to 2019
Authors: Antonova А. А. , Tumanov А. S. , Lebedev А. V. , Kozyennova Е. V. , Glinkina L. N. , Kulagin V. V. , Shemshura А. B. , Lebedev P. V. , Khoteleva L. V. , Bobkova M. R.
Published: August 2022

Objective.Molecular genetic analysis of AIDS-1, having spread in the territory of Krasnodar region over the 2014 to 2019, including analysis of drug resistance mutationMaterials and methods.The study used the collection of samples, obtained from 478 HIV-infected people, living in the territory of Krasnodar region over the 2014 to 2019; out of them 155 received antiretroviral therapy (ART). Genotyping of the obtained samples was carried out with the further phylogenetic analysis, including detailed analysis of identified unique recombinant forms of HIV-1.Results.It is shown that HIV-1 sub-subtype A6 (80,5%) continues dominating in the territory of Krasnodar region, genetic variant B (9,2%) is the second most common one. Also 11 unique recombinant forms (URFs) were discovered, 10 out of which are the result of A6 and B genetic variants recombination. Drug resistance mutations were registered with 114 patients, received ART (73,6%); primary mutations — M184V and A62V. Provisional indicator of transmissible drug resistance in the population of naïve patients is 4,6% (15/323); primary mutations — K103N и G190S.Conclusion.The analysis of genetic profile and HIV-1 drug resistance mutation is carried out in the territory of Krasnodar region over the 2014 to 2019.
Сlinical features of disorders of reproductive health and sexual behavior in women with HIV
Authors: Leschenko О. Ya. , Genich Е. V.
Published: August 2022

Objective. The research of clinical features, reproductive health and sexual disorders with women of childbearing age, involved in HIV epidemic.Materials and methods. Cross-sectional, cohort, clinical sociological research of gynecological pathology and comorbid conditions among 85 women with HIV infection. The results of sociological research by anonymous survey among 50 women and 35 men of reproductive age with HIV infection are presented. The research was held using a questionnaire, based on WHO thematic map-questionnaire (WHO project №88093).Results and discussion. The main group with HIV infection and reproductive disorders contains 27 women (median age 30,8±2,9). The comparison group consisted of 23 women with HIV infection without reproductive disorders (median age 31,4±7,1). The frequency of medical abortion appeared twice as often in the group of HIV-infected women with reproductive disorders. Statistically significant differences in occurrence of chronically related diseases: ENT organs, gastritis/duodenitis, pancreatitis, cystitis, pyelonerphritis, viral hepatitis (В, С), Papilloma Viral Infection in the compared groups has not been identified. The women with HIV infection and reproductive disorders experienced inflammatory disease of pelvic organs, provoked by chlamydia, gonorrhea, trichomoniasis, syphilis twice as often. Statistically significant differences in occurrence of hysteromyoma, chronic cervicitis, chronic endometritis, vulvovaginal candidiasis, cervical intraepithelial neoplasia haven’t been detected. Menstrual function analysis among the women with HIV infection and reproductive disorders identified a considerable predominance of secondary amenorrhea, opsomenorrhea, secondary oligomenorrhea and dysmenorrhea. The women with HIV infection and reproductive disorders experienced hyperprolactinemia syndrome 3 times as often. The men were married more often than the women, had regular sexual intercourse, were not interested in their partners’ pregnancy. The most common method of contraception for women as well as for men was contraception sheath and rejected sexual intercourse. However, 20% and 26% men and women with HIV infection, who had sexual intercourse, didn’t use any methods of contraception. The main reason for both men and women to refuse pregnancy planning was unsatisfactory financial situation and having current HIV infection.Conclusion. Early diagnosis of menstrual disorders, prevention of abortion and sexually transmitted diseases, and also early infertility treatment are necessary for women with HIV infection. Apart from medical care, medical workers should take into account social and psychological needs to help patients with HIV improve their quality of living, including sexual and reproductive health.
Epidemiology of tuberculosis combined with HIV infection, in the constituent entities of the Russian Federation with a low rate of tuberculosis prevalence
Authors: Lapshina I. S. , Tsybikova E. B. , Kulpesova M. A.
Published: August 2022

Objective. Analysis of the main epidemiological indicators characterizing the situation of tuberculosis combined with HIV infection in the Kaluga region for the period from 2015 to 2019.Materials and methods. For the analysis, was used information on 1159 newly diagnosed patients with tuberculosis, those who arenot infected with HIV infection, and 106 newly diagnosed patients with tuberculosis combined with HIV infection in the Kaluga region for the period from 2015 to 2020.Results. In the constituent entities of the Russian Federation, where the incidence of tuberculosis is declining annually, the registration of cases of tuberculosis combined with HIV infection is due to the spread of tuberculosis among HIV-infected contingents registered in AIDS centers.The main reasons for this situation are the late detection of tuberculosis among patients with HIV infection, when the course of the disease becomes widespread and low adherenceofpatients with HIV infectionto treatment antiretroviral drugs.
Gender specificities of neurodymanic processes and development of mental disorders with the HIV-infected
Authors: Khalezova N. B. , Rozhkov V. P. , Khobaysh M. А. , Zakharova N. G. , Kissin M. Ya. , Neznanov N. G. , Soroko S. I. , Belyakov N. А.
Published: August 2022

Objective. The study of gender specificities in adaptive transformation of regular neurodynamic (EEG) processes and also the development of maladaptation and mental disorders among men and women with HIV infection.Materials and methods. The research includes 46 men and 54 women, aged 18 and 60, on follow-up care in St. Petersburg Center of AIDS who didn’t get antiretroviral therapy. Clinical infectious, clinical psychiatric, experimental psychological, instrumental functional diagnostics (EEG). To describe neurodymanic processes, EEG spectral analysis was applied, as well as based on graph theory analysis of the structure of interaction (mutual transition of opposite) between wave components of basic EEG rhythms.Results and discussion. In the group of HIV-infected women the rate of mental illness is higher than in the men’s one. It is revealed the men and women have progressing frequency-dependent EEG changes due to neurotic, stress-related and organic mental disorders. Developing of HIV-encephalopathy among the women is accompanied by the growth of spectral power fluctuation in beta range and among the men — in alfa range of EEG frequency. These changes were most pronounced in the frontal and posttemporal areas both with the men and women that may reflect growing pathological process in structures of limbic system. Comparing to men, HIVinfected women have a higher EEG organization, characterized by high-frequency (beta) core formation of functional EGG rhythm interaction, representing decrease in the plasticity level of self-regulation process and developing stable pathological condition.Conclusion. Тhere are gender differences of psychic reaction on HIV infection, thus, it is necessary to have a personalized approach to patient care, taking into account a higher demand of women in psychocorrectional and psychopharmacological help.
Тhree similar cases of plasmablastic lymphoma in HIV-infected persons
Authors: Klimova N. V. , Gaus А. А. , Ramzina А. О. , Bazhuhina I. V.
Published: August 2022

X-ray morphological and clinical picture with three cases of plasmablastic lymphoma among HIV-infected with a distinctive localization of neoplastic process in the head-neck area is observed. Plasmablastic lymphoma is quite a rare pathology, characterized by extremely aggressive course of the disease and multiplicity of damage. Due to this fact, it represents a medical issue, as late diagnosis of the tumor leads to a high frequency of relapse and, accordingly, to poor prognosis.
On the procedure for referring citizens 18 years and older with HIV-AIDS for medical and social examination (to help a practicing doctor)
Authors: Ugleva E. M. , Yamschikova T. Yu.
Published: August 2022

The article discusses the main points of the form 088/u «Referral for medical and social examination (MSE) by a medical organization: drawn up by specialists of medical organizations (MO), when sending citizens for medical and social examination, causing difficulties in filling out for specialists of the MO and containing the greatest informative for MSE.
Analisa kepuasan konsumen terhadap kinerja pramusaji di titik temu coffee seminyak kuta bali
Authors: Dananjaya Anak Agung Ngurah
Published: August 2022

Penelitian ini bertujuan untuk mengetahui tingkat kepuasan konsumen Restoran Titik Temu Coffee Seminyak. Serta, untuk mengetahui indikator kinerja pramusaji yang perlu mendapatkan prioritas pelayanan di Titik Temu Coffee dalam meningkatkan kepuasan konsumen. Penelitian ini dilakukan di Titik Temu Coffee Seminyak, Bali. Penelitian ini di lakukan dari bulan Januari hingga Mei 2021. Jenis penelitian adalah deskripstif. Populasi adalah pelanggan Titik Temu Coffee Seminyak dengan sampel sebanyak 30 orang, Analisis yang digunakan adalah metode analisis data service servqual dan Importance-Performance Analysis, Dari Hasil Penelitian ini maka didapatkan kepuasan konsumen terhadap kinerja pramusaji di Titik Temu Coffee sebesar 78,7% yang artinya konsumen puas terhadap kinerja pramusaji pada Titik Temu Coffee. Atribut yang perlu ditingkatkan yaitu ketepatan waktu, kemandirian dan kualitas kerja.
Rereading Dystopia Literature: From E. Zamyatin's We to G. Orwell's 1984
Authors:   Institute of Foreign Literature, Kim Yeonkyung
Published: August 2022

This paper tries to reread three masterpieces of Dystopia Literature: E. Zamyatin's We, A. Huxley's Brave New World, and G. Orwell's 1984. First, We is examined as a kind of theoretical manifesto (dialectics of 'freedom and happiness') of this genre. Special attention is paid to the intrigue of Mephi (I-330), D-503's ‘betrayal', peculiarities of 'One State' (Utopia-Dystopia), 'Benefactor,' etc. The third chapter is dedicated to reading Brave New World. The novel shows serious thoughts on how to resolve such three problems as difference (class), sexuality (family egoism), and death. After that is followed the analysis of 1984 as an ideal Dystopia SF novel. This research focuses not only on political system but also on Winston Smith's rebellion and tragic catastrophe. In conclusion, this study hopes to study the 'former' Soviet SF such as the Strugatsky Brothers' novels.
Human rights and Humanism in Win Lyovarin’s True Blue
Authors:   Institute of Foreign Literature, Choi Nanoak
Published: August 2022

Thailand, formerly an absolute monarchy, was polarized due to the conflicts between the royal advocates who demanded a return to the existing system and those who advocated the need for a democratic system during the 1932 Constitutional Revolution and the 1933 Boworadet Rebellion. Win Lyovarin’s novel True Blue portrays the reality of the civil wars in Thailand as well as the political prisoners who were defeated during the turbulent period from 1933 to 1944. This study aims to find out the situation in Thailand where ideological conflicts had escalated into a civil war and human rights and humanism in the novel. This fictional work is about high-born royalty and intellectuals, who have been incarcerated as political prisoners, and contains ideas relating to their actions of resistance. The ideological conflicts that arose from the hopes of creating a better social system, the problems of human rights, the conditions and driving forces of human life, and the desire for humanism are sorely needed even today.
Acceptance of War Tanka and Japanese History Awareness
Authors:   Institute of Foreign Literature, Park Jiyoung
Published: August 2022

This study discusses the pattern in which war memories by Tanka poem relate to the public's history awareness. As a result of comparing of Showa Manyoshu with the exhibition contents of Yushkan and ShowaKan, it is found out that the composition of the editing is divided like a gallery in the memorial, and each Tanka was arranged by case to produce historical narratives. Tanka is directly used as an exhibition historical material for the memorial. Yushkan analyzes that Waka representing ‘Yamatogokoro’ and the Tanka of the fallen soldiers were exhibited to induce empathy of visitors. Meanwhile, Chiran Peace Museum gives meaning to the Last Tanka of the tokkō pilots as a message of peace for Japan's future. It says that Tanka is accepted in the logic of these memorial and produces history awareness associated with emotions.
INTERROGATIVE MOOD IN EXPOSITORY TEXTS FROM SCHOOL TEXTBOOKS
Authors: TRUSHCHELEV PAVEL N.
Published: August 2022

The article adopts a sociopragmatic approach to the study of expository text and considers it as a mode of educational interaction. The purpose of the study is to provide a sociopragmatic investigation of interrogative mood in expository texts. The material of the study is (Russian) expository texts from secondary school textbooks in Biology, Geography, History, Russian Language, Social Sciences, and Physics. By making the discourse analysis of text material and by drawing heavily on Relevance theory, the author illuminates five types of questions the textbooks include: expository questions, speculative questions, guess questions, exam questions, and rhetorical questions. The article describes four educational functions of interrogative mood in expository texts: increasing text-based interest, unfolding problem-based exposition, text structuring, and knowledge-building.
Evaluación de la deserción a nivel superior: dimensiones que inciden en carreras universitarias
Authors: Marrón Ramos Domingo Noé , Reyes Valenzuela Rigoberto , González Torres Arturo , Juárez Rodríguez Rubén , Mendoza Montero Fátima Yaraset
Published: August 2022

El propósito de este trabajo es examinar las variables que prevalecen en la deserción universitaria de dos carreras de educación superior. Para lograr el objetivo se aplicó un instrumento confiable y validado. Esta investigación se llevó a cabo en tres etapas. La primera consistió en las bases teóricas; la segunda comprendía la aplicación del estudio, y la tercera abarcó el examen de los datos. Los hallazgos muestran que la herramienta utilizada es válida para medir el propósito del análisis. Destaca que las variables latentes en la deserción universitaria son: Gestión universitaria, Vocación y apoyo y Exigencia y compañerismo. Asimismo, se concluye que existe un contraste significativo entre las dos carreras universitarias.
Investigation of Prospective Teachers’ Use of Mobile Technologies in Teaching Activities
Authors: Fatih Sapanca Hamza , Sami Kaya Omer , Taşpolat Ata , Tezer Murat
Published: August 2022

The purpose of this research is to examine the pre-service teachers’ use of mobile technologies in teaching activities. In this study, the survey method, one of the research methods, was used. The 199 prospective teachers studying at the Faculty of Education, a private university in Northern Cyprus, were included in the workgroup of the research. The 5-point Likert-type scales were used to measure the frequencies of using mobile technologies in instructional activities, motivation, and attitudes towards mobile technologies, competencies in mobile technology use, and its social effects. It was found that social factors had the lowest effect on the use of mobile technologies. Additionally, no gender-based difference was found in the mobile use frequency, motivation, attitude, competency, and social impact of prospective teachers. Moreover, the frequency, motivation, attitudes, competency, and social impact levels of students from the Department of Computer and Instructional Technologies are significantly higher than those departments from Guidance and Psychological Counselling, Special Education, Music Teaching, Elementary School Mathematics Teacher Education, Department of Pre-School Teaching, Classroom Teaching Department, Social Sciences Teacher Education, Turkish Language Teaching. It was concluded that having problems for mobile learning activities that can be used in the scope of mobile learning significantly influences the frequency of use, motivation, attitude, competency, and social impact of the students. Along with this, it was found that the following factors, given in order of importance, are influential on the frequency of the use of mobile technologies by prospective teachers in instructional activities: motivation, attitude, competency, and social impact.