bluuebunny/crossref_metadata_2025 huggingface dataset:
Against Latin American Regionalisms: The 1927 Brussels Congress and the Anti-Imperialist League of the Americas
Authors: Mahler Anne Garland
Published: March 2024

This article examines the encounter of activists from the Anti-Imperialist League of the Americas (LADLA) with African, African American, and Asian anticolonial intellectuals through the League Against Imperialism (LAI), founded at the 1927 Brussels Congress. Drawing from LADLA’s newspaperEl Libertador, letters from LADLA leaders, and speeches and resolutions in the LAI archive, it studies how exchanges begun in Brussels influenced debates in radical circles in the Americas. The article builds on extant scholarship and makes two primary interventions. First, it argues that a closer look at LADLA’s participation in the LAI shifts the traditional understanding of interwar Latin American regionalist ideologies, which LADLA rejected in favor of drawing connections to anti-imperialist movements around the world. Second, it argues that the exchange in Brussels influenced LADLA to eventually expand its initial focus on Indigenous struggles to think more critically about Black communities, including Black migrant labor, in political organizing.
The Southwest Silk Road: artistic exchange and transmission in early China
Authors: Elias Hajni
Published: March 2024

In examining wares discovered from the cultures of Sanxingdui and Jinsha and from the former site of the ancient kingdom of Dian in Sichuan and Yunnan provinces, this article highlights a number of shared features and trends that suggest a continued artistic, technological and cultural transmission through time and space. The article aims to supplement established theories on the rich material culture of this region. It will look in particular at the development of its striking bronze metallurgy, largely deriving from the established traditions of the Yellow River valley in China’s Bronze Age. It highlights the function of a dense network of trading routes, referred to in modern scholarship as the “Southwest Silk Road”, as an important facilitator of cultural and artistic exchange and reciprocation from ancient times.
Non-Archimedean population axiologies
Authors: Baker Calvin
Published: March 2024

Non-Archimedean population axiologies – also known as lexical views – claim (i) that a sufficient number of lives at a very high positive welfare level would be better than any number of lives at a very low positive welfare level and/or (ii) that a sufficient number of lives at a very low negative welfare level would be worse than any number of lives at a very high negative welfare level. Such axiologies are popular because they can avoid the (Negative) Repugnant Conclusion and satisfy the adequacy conditions given in the central impossibility result in population axiology due to Gustaf Arrhenius. I provide a novel argument against them which appeals to the way that good and bad lives can intuitively outweigh one another.
How to solve a binary cubic equation in integers
Authors: MASSER DAVID
Published: March 2024

Given any polynomial in two variables of degree at most three with rational integer coefficients, we obtain a new search bound to decide effectively if it has a zero with rational integer coefficients. On the way we encounter a natural problem of estimating singular points. We solve it using elementary invariant theory but an optimal solution would seem to be far from easy even using the full power of the standard Height Machine.
Care burden and support needs of caregivers of infants and children with CHDs and dysphagia
Authors: Norman Vivienne , Zühlke Liesl , Morrow Brenda
Published: March 2024

Dysphagia is common in children with CHDs, resulting in multiple stressors for their caregivers including having a child with a serious medical condition and coping with their child’s feeding needs. However, relatively little is known about caregivers’ perceptions and experiences of the burden of care and support needs for their child with a CHD and dysphagia in low-middle income contexts. This qualitative study investigated the burden of care and support needs identified by parents of children with CHDs and dysphagia in a single centre in South Africa. Semi-structured interviews took place in a tertiary hospital with seven mothers of children with CHDs and dysphagia, followed by content analysis. Participants described four main impacts of their child’s condition, which included worry, the burden of caregiving, emotional responses, and acceptance and coping. The participants were well-supported by speech-language therapists and dieticians, but suggestions for additional support included support groups and using mobile messaging apps for communication with peers and professionals. The study has important implications for understanding challenges faced by caregivers of children with complex needs in low-middle income settings and will be useful to inform and improve holistic healthcare practice for families of children with CHDs and dysphagia.
Evaluation of handgrip strength in children with pulmonary hypertension
Authors: Kavgacı Akif , Kula Serdar , Berber Maraşlı Elif , Zinnuroğlu Murat , Çelik Bülent , Terlemez Semiha , Tunaoğlu Sedef , Oğuz Deniz
Published: March 2024

Background:

Handgrip strength is a crucial indicator of upper extremity muscular strength and is vital for monitoring disorders like cardiac diseases that restrict a patient’s physical activity and result in muscle atrophy. The aim of our study was to evaluate whether muscle strength loss is present in patients with pulmonary hypertension and whether this test can be an alternative to 6-minute walk test.

Materials and methods:

The study included 39 healthy children who were admitted to the outpatient clinic and 16 children with a diagnosis of pulmonary hypertension who were being followed in our centre. We assessed the differences in upper extremity handgrip strength using the Jamar Hydraulic Hand Dynamometer device among both healthy children and those diagnosed with pulmonary hypertension. Moreover, we compared the handgrip strength of pulmonary hypertension patients with significant prognostic indicators such as NYHA class, 6-minute walk test, and pro-brain natriuretic peptide.

Results:

The mean dominant handgrip strength was 20.8 ± 12 kg in the patient group and 21.6 ± 12.4 kg in the control group (p = 0.970). Handgrip strength was shown to be negatively connected with pro-brain natriuretic peptide (r = −0.565, p = 0.023) and positively correlated with 6-minute walk test (r = 0.586, p = 0.022) during the patient group evaluation.

Conclusion:

Six-minute walk test needs a customised physical area (30 m of a straight hallway) and trained personnel for applying the test. The handgrip strength test, a different muscle strength indicator, can be used to more clearly and simply indicate the decline in patients’ ability for effort. Additionally, it was found in our study that handgrip strength decreased as pro-brain natriuretic peptide levels rose, a crucial measure in the monitoring of pulmonary hypertension.
The interaction of central and peripheral processing in L2 handwritten production: Evidence from cross-linguistic variations
Authors: Fu Yang , Álvarez Carlos J. , Bermúdez-Margaretto Beatriz , Afonso Olivia , Wang Huili , Domínguez Alberto
Published: March 2024

The current study explores the interplay between central and peripheral processes in second language (L2) handwriting among bilinguals with diverse orthographic backgrounds. Our investigation delves into the cross-linguistic transfer effect in Spanish–English and Chinese–English bilinguals, emphasizing lexical frequency and phoneme-grapheme (P-O) consistency in spelling-to-dictation and immediate copying tasks. Results reveal that the interaction between central and peripheral processes in L2 handwritten production is shaped by the bilinguals' native language (L1) orthographic characteristics. Spanish–English bilinguals exhibited sensitivity to P-O consistency and the spread of this effect from central to peripheral processes throughout both tasks. Conversely, Chinese–English bilinguals showed heightened sensitivity to lexical frequency during orthographic planning and motor execution, particularly in the immediate copying task. In a broader context, these findings suggest that the parallel and cascading coordination of the L2 writing system is modulated by cross-linguistic variations. The implications of our findings hold relevance for handwriting production and bilingualism research.
Evaluating Datalog Tools for Meta-reasoning over OWL 2 QL
Authors: QURESHI HAYA MAJID , FABER WOLFGANG
Published: March 2024

Metamodeling is a general approach to expressing knowledge about classes and properties in an ontology. It is a desirable modeling feature in multiple applications that simplifies the extension and reuse of ontologies. Nevertheless, allowing metamodeling without restrictions is problematic for several reasons, mainly due to undecidability issues. Practical languages, therefore, forbid classes to occur as instances of other classes or treat such occurrences as semantically different objects. Specifically, meta-querying in SPARQL under the Direct Semantic Entailment Regime uses the latter approach, thereby effectively not supporting meta-queries. However, several extensions enabling different metamodeling features have been proposed over the last decade. This paper deals with the Metamodeling Semantics (MS) over OWL 2 QL and the Metamodeling Semantic Entailment Regime (MSER), as proposed in Lenzerini et al. (2015, Description Logics) and Lenzerini et al. (2020, Information Systems 88, 101294), Cima et al. (2017, Proceedings of the 7th International Conference on Web Intelligence, Mining and Semantics, 1–6). A reduction from OWL 2 QL to Datalog for meta-querying was proposed in Cima et al. (2017, Proceedings of the 7th International Conference on Web Intelligence, Mining and Semantics, 1–6). In this paper, we experiment with various logic programming tools that support Datalog querying to determine their suitability as back-ends to MSER query answering. These tools stem from different logic programming paradigms (Prolog, pure Datalog, Answer Set Programming, Hybrid Knowledge Bases). Our work shows that the Datalog approach to MSER querying is practical also for sizeable ontologies with limited resources (time and memory). This paper significantly extends Qureshi and Faber (2021, International Joint Conference on Rules and Reasoning, Springer, 218–233.) by a more detailed experimental analysis and more background.
Hayek's extended mind: on the (im)possibility of Austrian behavioural economics
Authors: Dekker Erwin , Remic Blaž
Published: March 2024

Recent work has argued for a Hayekian behavioural economics, which combines Austrian economics with behavioural economics as developed by Kahneman, Thaler, Sunstein, and others. We suggest that this hybrid is misguided because it relies on individual cognitivism. This view of cognition is incompatible with the Hayekian view of cognition which treats rationality as an emergent phenomenon of social interaction in an institutional environment. This Hayekian view, which we call epistemic institutionalism, is compatible with an alternative prominent perspective in psychology, that of the extended mind, sometimes known as 4E cognition. We demonstrate how the Hayekian perspective on individualism, the price system, and the evolution of rules can be connected to the extended mind programme, through concepts such as the coupling of the individual and their environment, cognitive off-loading, and affordances. We suggest that this alternative combination of Austrian economics and psychology provides a more fruitful way forward, especially because it foregrounds the processes of learning, error-correction, and institutional orders, rather than choice, bias, and individual rationality. To explain why Austrian economists have been receptive to behavioural economics, we distinguish epistemic institutionalism from the (radical) subjectivist approach, which shares key assumptions of individual cognitivism.
Combining 77–81 GHz MIMO FMCW radar with frequency-steered antennas: a case study for 3D target localization
Authors: Kwiatkowski Patrick , Orth Alexander , Pohl Nils
Published: March 2024

In this paper, we introduce a compact 6 × 8 channel multiple-input multiple-output frequency-modulated continuous-wave radar system capable of determining the three-dimensional positions of targets despite utilizing a linear virtual array. The compact system, containing two cascaded radar transceiver ICs, has 48 virtual channels. We conduct a direction of arrival estimation with these virtual channels to determine the azimuth angle. To overcome the spatial limitation of the linear array, we use frequency-steered transmit antennas, which vary their main lobe direction during the frequency chirp, allowing the elevation angle to be determined by using a sliding window fast Fourier transform algorithm. In this study, we present the system’s concept along with the associated signal processing. By taking measurements in different scenarios, each with differently placed corner reflectors, we investigate the capability of the system to separate adjacent targets concerning range, azimuth, and elevation. These measurements are additionally employed to point out the design trade-offs inherent to the system.
Broadband packaging solution in embedded wafer level ball grid array technology for D-band PMCW radar
Authors: Bekker Elizabeth , Gramlich Georg , Valenziano Luca , de Oliveira Lucas Giroto , Antes Theresa , Zwick Thomas , Bhutani Akanksha
Published: March 2024

A system-in-package for a wideband digital radar, in D-band, requires broadband, high-gain antennas combined with broadband chip-to-package and package-to-printed circuit board (PCB) interconnects. This paper demonstrates a wideband, low-loss quasi-coaxial signal transition, and a novel electric split ring resonator (eSRR)-based antenna-in-package (AiP) with a modified reflector concept, for improved gain, in embedded wafer level ball grid array (eWLB) technology. A complete chip-to-package-to-PCB interconnect is also demonstrated by combining the quasi-coaxial transition with a chip-to-package interconnect. The quasi-coaxial signal transition has the largest impedance bandwidth among ball grid array-based quasi-coaxial signal transitions. For the modified reflector concept, a horn-shaped cavity is micromachined in the PCB substrate and remetallized with aerosol-jet printing, placing the reflector 0.25λ from the antenna. The antenna gain is improved with up to 5.3 dB. The AiP with the horn-shaped reflector is the single element with the highest gain, in eWLB technology, above 100 GHz.
The developmental origins of health and disease and intergenerational inheritance: a scoping review of multigenerational cohort studies
Authors: Tan Jie , Zhang Zifang , Yan Lijing L. , Xu Xiaolin
Published: March 2024

Epidemiologic research has increasingly acknowledged the importance of developmental origins of health and disease (DOHaD) and suggests that prior exposures can be transferred across generations. Multigenerational cohorts are crucial to verify the intergenerational inheritance among human subjects. We carried out this scoping review aims to summarize multigenerational cohort studies’ characteristics, issues, and implications and hence provide evidence to the DOHaD and intergenerational inheritance. We adopted a comprehensive search strategy to identify multigenerational cohorts, searching PubMed, EMBASE, and Web of Science databases from the inception of each dataset to June 20th, 2022, to retrieve relevant articles. After screening, 28 unique multigenerational cohort studies were identified. We classified all studies into four types: population-based cohort extended three-generation cohort, birth cohort extended three-generation cohort, three-generation cohort, and integrated birth and three-generation cohort. Most cohorts (n = 15, 53%) were categorized as birth cohort extended three-generation studies. The sample size of included cohorts varied from 41 to 167,729. The study duration ranged from two years to 31 years. Most cohorts had common exposures, including socioeconomic factors, lifestyle, and grandparents’ and parents’ health and risk behaviors over the life course. These studies usually investigated intergenerational inheritance of diseases as the outcomes, most frequently, obesity, child health, and cardiovascular diseases. We also found that most multigenerational studies aim to disentangle genetic, lifestyle, and environmental contributions to the DOHaD across generations. We call for more research on large multigenerational well-characterized cohorts, up to four or even more generations, and more studies from low- and middle-income countries.
Anaesthesia and brain development: a review of propofol-induced neurotoxicity in pediatric populations
Authors: Zhang Weixin , Liu Qi , Wang Junli , Liu Li
Published: March 2024

With the advancement of medical technology, there are increasing opportunities for new-borns, infants, and pregnant women to be exposed to general anaesthesia. Propofol is commonly used for the induction of anaesthesia, maintenance of general intravenous anaesthesia and sedation of intensive-care children. Many previous studies have found that propofol has organ-protective effects, but growing evidence suggests that propofol interferes with brain development, affecting learning and cognitive function. The purpose of this review is to summarize the latest progress in understanding the neurotoxicity of propofol. Evidence from case studies and clinical studies suggests that propofol has neurotoxicity on the developing brain. We classify the findings on propofol-induced neurotoxicity based on its damage mechanism. We end by summarizing the current protective strategies against propofol neurotoxicity. Fully understanding the neurotoxic mechanisms of propofol can help us use it at a reasonable dosage, reduce its side effects, and increase patient safety.
Evaluation of Leaf‐To‐Canopy Upscaling Approaches for Simulating Canopy Carbonyl Sulfide Uptake and Gross Primary Productivity
Authors: Chen Bin , Wang Pengyuan , Wang Shaoqiang , Liu Zhenhai , Croft Holly
Published: March 2024

Carbonyl sulfide (COS) measurements provide an important mechanism for quantifying the terrestrial carbon and water cycles. Terrestrial photosynthesis can be inferred from vegetative uptake of COS due to the shared diffusion pathway of COS and CO2 into the chloroplasts. However, the efficacy of different leaf‐to‐canopy upscaling approaches for estimating plant COS uptake and photosynthesis at the canopy scale remains uncertain. In this study, the daytime canopy COS uptake rate (Fcosc) and gross primary productivity (GPP) were simulated using big leaf (BL), two big leaf (TBL) and two leaf (TL) upscaling approaches in the Boreal Ecosystem Productivity Simulator terrestrial biosphere model for two forest sites. We found that TL and TBL performed better than BL in estimating GPP as evaluated by the eddy covariance derived GPP at the studied sites. BL overestimated GPP and canopy stomatal conductance to COS (Gs_cos), resulting from the overestimation of canopy intercepted solar radiation. The positive biases of GPP by TBL could be attributed to the positive biases in GPP of shaded leaves by TBL. The results in this study demonstrate the improved accuracy in using TL for estimating GPP at the canopy scale. Improved leaf‐to‐canopy upscaling approach in terrestrial biosphere models will improve the accuracy of canopy COS uptake and GPP estimation on regional to global scales.
Different Response of the Ionospheric TEC and EEJ to Ultra‐Fast Kelvin Waves in the Mesosphere and Lower Thermosphere
Authors: Sun Ruidi , Gu Sheng‐Yang , Dou Xiankang , Qin Yusong , Wei Yafei
Published: March 2024

We studied the response of ionospheric total electron content (TEC) and equatorial electrojet (EEJ) to the ultra‐fast Kelvin wave (UFKW) at the equator in the mesosphere using zonal wind data obtained from TIMED Doppler Interferometer (TIDI), EEJ data over the monitoring station Jicamarca (12°S, 77°W) and global TEC maps. The least squares fitting method is utilized to perform a spectral analysis of zonal wind, EEJ and TEC. Our analysis results demonstrate that UFKW events can be divided into four categories: (a) UFKW events with both TEC and EEJ response; (b) UFKW events with TEC response but without EEJ response; (c) UFKW events with EEJ response but without TEC response; (d) UFKW events without neither TEC response nor EEJ response. The first type of UFKW events occur the most often and is generally thought to generate a response in EEJ at approximately 105–110 km through the dynamo effect. The polarization electric field associated with EEJ then produces a response in the ionospheric TEC through the fountain effect. The lack of EEJ response in the second type of UFKWs may be due to the influence of eastward background winds. We found that all UFKW events with EEJ response have a response in TEC. The fourth type of UFKWs have smaller amplitudes, shorter vertical wavelengths and longer periods, which make them more likely to dissipate and cannot propagate to higher altitudes. These UFKWs cannot propagate to the altitude of EEJ and produce a response in EEJ, much less in TEC.
Predicting Ecosystem Net Primary Productivity by Percolation Theory and Optimality Principle
Authors: Hunt Allen G. , Sahimi Muhammad , Ghanbarian Behzad , Poveda German
Published: March 2024

The basic partitioning of precipitation P into evapotranspiration ET and run‐off Q is known as the “central problem of hydrology.” ET depends primarily on precipitation, P, and potential evapotranspiration, PET, which are connected by the biological process of photosynthesis. Photosynthesis is the fundamental step underlying the productivity of plant ecosystems. An important measure of plant productivity is the creation of plant biomass, which is quantified by net primary productivity, NPP. NPP is most parsimoniously related simply to the evapotranspiration, ET. The dependence of NPP (ET) appears to be in the form of a power law with an upper limit derived from the maximum plant‐available solar energy accessible on Earth. However, theoretical, rather than phenomenological, treatments relating ET and its complementary variable, run‐off (P − ET ≡ Q) to climate variables that measure the available energy (PET) and available water (P) (known as the water balance) are, at best, scarce, and their continued application to predicting NPP (P, PET) even more so. One theory developed recently to predict the water balance is based on determining how to divide P into Q and ET in such a way as to maximize NPP. Substitution of the resulting optimized ET (P, PET) into the function NPP (ET) then yields NPP (P, PET). We investigate the possibility that this new theoretical framework, which yields ET(P, PET) based on ecological optimality and percolation theory, can predict the dependence of NPP (P, PET). If the prediction of NPP (P, PET) is verified, this result may lead to significant progress in other areas, including the problem of the chief causes of geographical variability of species richness.
The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma
Authors: Lantermans Hildo C. , Ma Fangxue , Kuil Annemieke , van Kesteren Sanne , Yasinoglu Sevtap , Yang Guang , Buhrlage Sara J. , Wang Jinhua , Gray Nathanael S. , Kersten Marie José , Treon Steven P. , Pals Steven T. , Spaargaren Marcel
Published: March 2024

Although Bruton’s tyrosine kinase (BTK) inhibitors (BTKi) have significantly improved patient prognosis, mantle cell lymphoma (MCL) is still considered incurable due to primary and acquired resistance. We have recently shown that aberrant expression of the Src-family tyrosine kinase hematopoietic cell kinase (HCK) in MCL correlates with poor prognosis, and that genetic HCK perturbation impairs growth and integrin-mediated adhesion of MCL cells. Here, we show that KIN-8194, a dual inhibitor of BTK and HCK with in vivo activity against Myd88-L265P-driven diffuse large B-cell lymphoma and Waldenström Macroglobulinemia, has a potent growth inhibitory effect in MCL cell lines and primary MCL cells, irrespective of their sensitivity to BTKi (ibrutinib and acalabrutinib). In BTKi-resistant cells this is mediated by inhibition of HCK, which results in repression of AKT-S6 signaling. In addition, KIN-8194 inhibits integrin-mediated adhesion of BTKi-sensitive and insensitive MCL cells to fibronectin and stromal cells in an HCK-dependent manner. Finally, we show that MCL cells with acquired BTKi resistance retain their sensitivity to KIN-8194. Taken together, our data demonstrate that KIN-8194 inhibits growth and integrin-mediated adhesion of BTKi-sensitive MCL cells, as well as MCL cells with primary or acquired BTKi resistance. This renders KIN-8194 a promising novel treatment for MCL patients.
Regulation of HOX gene expression in AML
Authors: Khan Irum , Amin Mohammed A. , Eklund Elizabeth A. , Gartel Andrei L.
Published: March 2024

As key developmental regulators, HOX cluster genes have varied and context-specific roles in normal and malignant hematopoiesis. A complex interaction of transcription factors, epigenetic regulators, long non-coding RNAs and chromatin structural changes orchestrate HOX expression in leukemia cells. In this review we summarize molecular mechanisms underlying HOX regulation in clinical subsets of AML, with a focus on NPM1 mutated (NPM1mut) AML comprising a third of all AML patients. While the leukemia initiating function of the NPM1 mutation is clearly dependent on HOX activity, the favorable treatment responses in these patients with upregulation of HOX cluster genes is a poorly understood paradoxical observation. Recent data confirm FOXM1 as a suppressor of HOX activity and a well-known binding partner of NPM suggesting that FOXM1 inactivation may mediate the effect of cytoplasmic NPM on HOX upregulation. Conversely the residual nuclear fraction of mutant NPM has also been recently shown to have chromatin modifying effects permissive to HOX expression. Recent identification of the menin-MLL interaction as a critical vulnerability of HOX-dependent AML has fueled the development of menin inhibitors that are clinically active in NPM1 and MLL rearranged AML despite inconsistent suppression of the HOX locus. Insights into context-specific regulation of HOX in AML may provide a solid foundation for targeting this common vulnerability across several major AML subtypes.
Medication adherence halves COPD patients’ hospitalization risk – evidence from Swiss health insurance data
Authors: Bischof Anja Y. , Cordier Johannes , Vogel Justus , Geissler Alexander
Published: March 2024

Medication adherence is vital for patients suffering from Chronic Obstructive Pulmonary Disease (COPD) to mitigate long-term consequences. The impact of poor medication adherence on inferior outcomes like exacerbations leading to hospital admissions is yet to be studied using real-world data. Using Swiss claims data from 2015-2020, we group patients into five categories according to their medication possession ratio. By employing a logistic regression, we quantify each category’s average treatment effect of the medication possession ratio on hospitalized exacerbations. 13,557 COPD patients are included in the analysis. Patients with high medication adherence (daily medication reserve of 80% to 100%) are 51% less likely to incur exacerbation following a hospital stay than patients with the lowest medication adherence (daily medication reserve of 0% to 20%). The study shows that medication adherence varies strongly among Swiss COPD patients. Furthermore, high medication adherence immensely decreases the risk of hospitalized exacerbations.
An Integrated Multi-Source Dataset for Measuring Settlement Evolution in the United States from 1810 to 2020
Authors: Ahn Yoonjung , Leyk Stefan , Uhl Johannes H. , McShane Caitlin M.
Published: March 2024

Understanding changes in the built environment is vital for sustainable urban development and disaster preparedness. Recent years have seen the emergence of a variety of global, continent-level, and nation-wide datasets related to the current state and the evolution of the built environment, human settlements or building stocks. However, such datasets may face limitations like incomplete coverage, sparse building information, coarse resolution, and limited timeframes. This study addresses these challenges by integrating three spatial datasets to create an extensive, attribute-rich sequence of settlement layers spanning 200 years for the contiguous U.S. This integration process involves complex data processing, merging property-level real estate, parcel, and remote sensing-based building footprint data, and creating gridded multi-temporal settlement layers. This effort unveils the latest edition (Version 2) of the Historical Settlement Data Compilation for the U.S. (HISDAC-US), which includes the latest land use and structural information as of the year 2021. It enables detailed research on urban form and structure, helps assess and map the built environment’s risk to natural hazards, assists in population modeling, supports land use analysis, and aids health studies.
The mechanisms underlying conditioning of phantom percepts differ between those with hallucinations and synesthesia
Authors: del Rio Magdalena , Kafadar Eren , Fisher Victoria , D’Costa Rhys , Powers Albert , Ward Jamie
Published: March 2024

There are many different kinds of ‘phantom’ percepts but it is unknown whether they are united by common mechanisms. For example, synaesthesia (e.g., numbers evoking colour) and hallucinations appear conceptually and phenomenologically similar: both result in a percept that does not have an environmental correlate. Here, people with synaesthesia (n = 66) performed a conditioned hallucinations paradigm known to be sensitive to hallucination susceptibility, and we asked whether synaesthetes would show the same behavioural profile as hallucinators in this task. Repeated pairing of checkerboards with tones, and gratings with colours encourages the participant to draw on prior knowledge when asked to report on the presence of the difficult-to-detect target stimulus. Synaesthetes show increased modelled expectancies for the stimulus association across the board, resulting in a higher number of detections at all stimulus intensities. This is in contrast to the pattern observed in hallucinators, who weigh their prior beliefs more strongly than controls, giving rise to more conditioned hallucinations. Results indicate that fundamentally different perceptual processes may be at the core of these seemingly similar experiences.
Silver molybdate: an excellent optical limiting material under nanoregime for photonic device application
Authors: Binish B. , Lokesh B. , Veer Yukesh , Peters Silda , Abith M. , Girisun T. C. Sabari , Rahulan K. Mani
Published: March 2024

There is a mounting demand for nonlinear optical materials with superior optical limiting performance which has a noticeable impact on protecting the delicate optical components from laser-induced damage. Transition metal molybdates have garnered attention in the nonlinear optics field due to their outstanding optical and luminescent properties, which give rise to widespread applications in next-generation optoelectronics devices. The structural confirmation of the as prepared silver molybdate nanoparticles were made by XRD and Raman spectroscopy analysis. The linear optical properties and the band gap of the synthesized material were studied using UV–Visible and photoluminescence spectroscopy. SEM analysis revealed the pebble like morphology of the silver molybdate nanostructures. The nonlinear responses of the samples were studied using open aperture z-scan approach with Nd:YAG pulsed laser (532 nm, 9 ns, 10 Hz). The sample exhibits reverse saturable absorption pattern attributed to the two photon absorption (2PA) mechanism. The obtained OL threshold value is in the order of 1012 which is suitable for fabricating optical limiters in nano second pulsed laser regime.
Bioinformatics analysis and experimental validation revealed that Paeoniflorigenone effectively mitigates cerebral ischemic stroke by suppressing oxidative stress and inflammation
Authors: Wu Zhiyan , Tang Xingrong
Published: March 2024

Inflammation and oxidative stress are becoming more recognized as risk factors for ischemic stroke. Paeoniflorigenone (PA) has diverse pharmacological effects that include anti-inflammatory and antioxidant properties. However, the specific mechanisms by which PA affects cerebral ischemic stroke have not been studied. Our objective was to investigate the potential targets and mechanisms of PA in preventing cerebral ischemic stroke. We obtained the potential targets of PA from the SwissTargetPrediction, Super-PRED, and SEA Search Server databases. The GSE97537 dataset was utilized to identify gene targets related to ischemic stroke. The overlapping targets were imported into the STRING database to construct a protein–protein interaction network, and enrichment analyses were conducted using R software. Rats were pretreated with PA for three weeks before undergoing MCAO and reperfusion. H&E staining, ELISA, and qRT-PCR analyses were then performed to explore the potential mechanisms of PA. In the study, we identified 439 potential targets for PA and 1206 potential targets for ischemic stroke. Out of these, there were 71 common targets, which were found to be primarily associated with pathways related to oxidative stress and inflammation. The results from animal experiments showed that PA was able to improve nerve function and reduce inflammatory cytokines and oxidative stress in the MCAO-induced ischemic stroke model. Additionally, the expression of core genes in the MCAO + HPA group was significantly lower compared to the MCAO group. Our study revealed that the potential mechanisms by which PA prevents ischemic stroke involve oxidative stress and inflammation. These findings provide important theoretical guidance for the clinical use of PA in preventing and managing ischemic stroke.
A ketogenic diet rich in fish oil is superior to other fats in preventing NNK-induced lung cancer in A/J mice
Authors: Elisia Ingrid , Yeung Michelle , Kowalski Sara , Shyp Taras , Tee Jason , Hollman Serena , Wong Amy , King Janette , Dyer Roger , Sorensen Poul H. , Krystal Gerald
Published: March 2024

Given that ketogenic diets (KDs) are extremely high in dietary fat, we compared different fats in KDs to determine which was the best for cancer prevention. Specifically, we compared a Western and a 15% carbohydrate diet to seven different KDs, containing either Western fats or fats enriched in medium chain fatty acids (MCTs), milk fat (MF), palm oil (PO), olive oil (OO), corn oil (CO) or fish oil (FO) for their ability to reduce nicotine-derived nitrosamine ketone (NNK)-induced lung cancer in mice. While all the KDs tested were more effective at reducing lung nodules than the Western or 15% carbohydrate diet, the FO-KD was most effective at reducing lung nodules. Correlating with this, mice on the FO-KD had low blood glucose and the highest β-hydroxybutyrate level, lowest liver fatty acid synthase/carnitine palmitoyl-1a ratio and a dramatic increase in fecal Akkermansia. We found no liver damage induced by the FO-KD, while the ratio of total cholesterol/HDL was unchanged on the different diets. We conclude that a FO-KD is superior to KDs enriched in other fats in reducing NNK-induced lung cancer, perhaps by being the most effective at skewing whole-body metabolism from a dependence on glucose to fats as an energy source.
The prevalence, clinical reasoning and impact of non-standard anti-tuberculosis regimens at the initial prescription
Authors: Chen Rou-Tsern , Liu Chih-Yu , Lin Shu-Yung , Shu Chin-Chung , Sheng Wang-Huei
Published: March 2024

Regarding clinically-concerning non-standard initial anti-tuberculous (TB) regimens, few studies have examined their prevalence, risk factors and impacts. We recruited patients with drug susceptible TB and non-standard initial anti-TB regimens (NSTB group) and matched them with patients with standard initial regimens (STB group) in a 1:1 ratio. The risk factors and outcomes were analyzed. During the 11-year study period, we analyzed 50 (3.7%) patients with NSTB from a total set of 1337 patients with drug-susceptible TB. Pyrazinamide (60%) was the drug most commonly not prescribed in the NSTB group, followed by ethambutol (34%). Multivariable logistic regression identified independent risk factors as underlying eye disease (adjusted odds ratio [aOR]: 8.869; 95% CI 2.542–30.949; p = 0.001), gout/hyperuricemia (aOR: 4.012 [1.196–13.425]; p = 0.024), and liver disease (aOR: 12.790 [3.981–41.089]; p < 0.001). The NSTB group had longer treatment durations (281 ± 121 vs. 223 ± 63 days; p = 0.003) and more occurrences of treatment interruption (26% vs. 8%; p = 0.021) than the STB group. In conclusion, NSTB occurs in around 3.7% of patients and is associated with longer treatment and more treatment interruption. The risk factors might include underlying liver and eye diseases, and gout. Further studies to improve non-standard initial regimens and prevent negative outcomes are warranted.
Experimental and numerical study of the mixed lubrication under the action of magnetic ionic liquid additives
Authors: Liu Ze , Yan Zhijun , Wu Shibo , Sun Haocheng , Zhang Shengwei
Published: March 2024

In this paper, the tribological characteristics of an oil-soluble magnetic fluid additive under mixed lubrication are studied by experiments and numerical simulation. [bmim][FeCl4] is dissolved in CF10W-40 lubricating oil as a magnetic liquid additive, and its friction coefficient is tested by a point contact friction tester at different temperatures, rotational speeds and magnetic field intensities. The transition condition of lubrication state is obtained through analyzing the Stribeck curves based on the experiments, and the strength model of boundary film is established accordingly. A mixed lubrication model is established by substituting the boundary film strength model and the surface roughness model into the hydrodynamic lubrication model based on Reynolds equation. The results show that the magnetic solution as an additive can obviously reduce friction and wear, and the effect is more obvious under the condition of magnetic field. The boundary film strength model can accurately reflect the transition characteristics of lubrication state in the presence of boundary film, and the mixed lubrication model based on boundary film strength model can more precisely reflect the tribological characteristics of friction pairs, so this study provides a new theoretical method for the related research on the influence of boundary film on lubrication characteristics.
Study of the influence of tributyrin-supplemented diets on the gut bacterial communities of rainbow trout (Oncorhynchus mykiss)
Authors: Louvado A. , Coelho F. J. R. C. , Palma M. , Magnoni L. J. , Silva-Brito F. , Ozório R. O. A. , Cleary D. F. R. , Viegas I. , Gomes N. C. M.
Published: March 2024

Dietary supplementation with triglyceride tributyrin (TBT), a butyrate precursor, has been associated with beneficial effects on fish health and improvements in the ability of carnivorous fish to tolerate higher levels of plant-based protein. In this study, we aimed to investigate the effects of a plant-based diet supplemented with TBT on the structural diversity and putative function of the digesta-associated bacterial communities of rainbow trout (Oncorhynchus mykiss). In addition to this, we also assessed the response of fish gut digestive enzyme activities and chyme metabolic profile in response to TBT supplementation. Our results indicated that TBT had no significant effects on the overall fish gut bacterial communities, digestive enzyme activities or metabolic profile when compared with non-supplemented controls. However, a more in-depth analysis into the most abundant taxa showed that diets at the highest TBT concentrations (0.2% and 0.4%) selectively inhibited members of the Enterobacterales order and reduced the relative abundance of a bacterial population related to Klebsiella pneumoniae, a potential fish pathogen. Furthermore, the predicted functional analysis of the bacterial communities indicated that increased levels of TBT were associated with depleted KEGG pathways related to pathogenesis. The specific effects of TBT on gut bacterial communities observed here are intriguing and encourage further studies to investigate the potential of this triglyceride to promote pathogen suppression in the fish gut environment, namely in the context of aquaculture.
Relationships between perception of black triangles appearance, personality factors and level of education
Authors: AL-Omiri Mahmoud K. , Atieh Danial Waleed Ahmad , Al Nazeh Abdullah A. , Almoammar Salem , Bin Hassan Saeed Awod , Alshadidi Abdulkhaliq Ali F. , Aldosari Lujain Ibrahim N. , Aljehani Ahmad , Shat Naji M. , Lynch Edward
Published: March 2024

This analytical cross-sectional study evaluated the perception of black triangles (BT) and examined the relationships between the perception of BT, personality factors, different educational backgrounds and demographic factors. 435 participants were included and divided into four groups: dentists, clinical (4th and 5th year) dental students, pre-clinical (3rd year) dental students, and laypeople. Participants’ perception of the attractiveness of smile profiles of maxillary and mandibular anterior dentition with BT was rated using a ten-point VAS scale with 0 being the least, and 10 being the most attractive smile profile. The personality was assessed using the NEO-FFI personality questionnaire. The smile profile with multiple large BT was rated the least attractive for the maxillary (mean = 3.6) and mandibular (mean = 3.9) tested profiles. The smile profile without BT was rated the most attractive for the maxillary (mean = 9.1) and mandibular (mean = 8.8) tested profiles. The dental professionals perceived the maxillary smile profile with multiple large BT as less attractive than the non-dental participants (t = − 2.715, P = 0.007). Being a male, having dental education, having lower Neuroticism scores, as well as having higher Openness, Agreeableness, Conscientiousness, and Extraversion scores predicted and contributed more towards perceiving various tested smile profiles as more attractive. These findings show that black triangles negatively impacts the perception of smile attractiveness, and that personality traits and having dental education impact the perception of smile attractiveness for smiles with black triangles.
Clinical features and associated factors of coexisting intracerebral hemorrhage in patients with cerebral small vessel disease: a cross-sectional study
Authors: Gao Yuan , Zong Ce , Liu Hongbing , Zhang Ke , Yang Hongxun , Wang Yunchao , Li Yusheng , Song Bo , Xu Yuming
Published: March 2024

Intracerebral hemorrhage (ICH) is generally considered to be closely related to cerebral small vessel disease (CSVD), leading to a poor prognosis. However, the coexistence of ICH in general CSVD patients and related factors remain underreported. In our cross-sectional study, we screened 414 CSVD patients from a database at the Department of Neurology, First Affiliated Hospital of Zhengzhou University (September 2018 to April 2022). Imaging biomarkers of CSVD and coexisting ICH lesion were assessed. Factors associated with coexisting ICH in CSVD were determined using multivariate logistic regression analysis. ICH was observed in 59 patients (14.3%). Multivariate logistic regression showed that previous history of ischemic stroke or transient ischemic attack (OR 5.189, 95%CI 2.572–10.467, P < 0.001), high-grade perivascular space in the basal ganglia (n > 10) (OR 2.051, 95%CI 1.044–4.027, P = 0.037) and low adjusted calcium-phosphorus product (OR 0.728 per 1 [mmol/L]2 increase, 95%CI 0.531–0.998, P = 0.049) were associated with coexisting ICH in CSVD patients. The considerable proportion of coexisting ICH and revelation of associated factors in general CSVD patients alert physicians of the potential risk of the reoccurrence of ICH, and might have a significant impact on therapeutic strategies.
Comparison between epileptic seizure prediction and forecasting based on machine learning
Authors: Costa Gonçalo , Teixeira César , Pinto Mauro F.
Published: March 2024

Epilepsy affects around 1% of the population worldwide. Anti-epileptic drugs are an excellent option for controlling seizure occurrence but do not work for around one-third of patients. Warning devices employing seizure prediction or forecasting algorithms could bring patients new-found comfort and quality of life. These algorithms would attempt to detect a seizure’s preictal period, a transitional moment between regular brain activity and the seizure, and relay this information to the user. Over the years, many seizure prediction studies using Electroencephalogram-based methodologies have been developed, triggering an alarm when detecting the preictal period. Recent studies have suggested a shift in view from prediction to forecasting. Seizure forecasting takes a probabilistic approach to the problem in question instead of the crisp approach of seizure prediction. In this field of study, the triggered alarm to symbolize the detection of a preictal period is substituted by a constant risk assessment analysis. The present work aims to explore methodologies capable of seizure forecasting and establish a comparison with seizure prediction results. Using 40 patients from the EPILEPSIAE database, we developed several patient-specific prediction and forecasting algorithms with different classifiers (a Logistic Regression, a 15 Support Vector Machines ensemble, and a 15 Shallow Neural Networks ensemble). Results show an increase of the seizure sensitivity in forecasting relative to prediction of up to 146% and in the number of patients that displayed an improvement over chance of up to 300%. These results suggest that a seizure forecasting methodology may be more suitable for seizure warning devices than a seizure prediction one.
High-throughput analysis of the Trypanosoma cruzi minicirculome (mcDNA) unveils structural variation and functional diversity
Authors: Gómez-Palacio Andrés , Cruz-Saavedra Lissa , Van den Broeck Frederik , Geerts Manon , Pita Sebastián , Vallejo Gustavo A. , Carranza Julio C. , Ramírez Juan David
Published: March 2024

Trypanosoma cruzi causes Chagas disease and has a unique extranuclear genome enclosed in a structure called the kinetoplast, which contains circular genomes known as maxi- and minicircles. While the structure and function of maxicircles are well-understood, many aspects of minicircles remain to be discovered. Here, we performed a high-throughput analysis of the minicirculome (mcDNA) in 50 clones isolated from Colombia’s diverse T. cruzi I populations. Results indicate that mcDNA comprises four diverse subpopulations with different structures, lengths, and numbers of interspersed semi-conserved (previously termed ultra-conserved regions mHCV) and hypervariable (mHVPs) regions. Analysis of mcDNA ancestry and inter-clone differentiation indicates the interbreeding of minicircle sequence classes is placed along diverse strains and hosts. These results support evidence of the multiclonal dynamics and random bi-parental segregation. Finally, we disclosed the guide RNA repertoire encoded by mcDNA at a clonal scale, and several attributes of its abundance and function are discussed.