bluuebunny/crossref_metadata_2025 huggingface dataset:
From OFF to ON—Treating OFF Episodes in Parkinson’s Disease
Authors: Olanow C Warren ,   Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Poewe Werner ,   Department of Neurology, Innsbruck Medical University, Innsbruck, Austria, Rascol Olivier ,   Research Network Departments of Clinical Pharmacology and Neuroscience, Toulouse University Hospital, Toulouse, France, Stocchi Fabrizio ,   Department of Neurology, IRCCS San Raffaele Pisana, Rome, Italy
Published: January 2023

In Parkinson’s disease (PD), OFF episodes continue to present a serious burden for patients, and their effective management remains a substantial unmet clinical need. Understanding of the pathophysiology of OFF episodes has advanced in recent years, providing valuable insights for improved treatments. OFF episodes generally appear 3–5 years after starting levodopa treatment, but can begin much earlier. They are characterized by motor symptoms (including tremor, rigidity, slowness, incoordination, and weakness) and are almost always associated with some non-motor symptoms (including psychological symptoms, pain, urinary problems, swallowing difficulties, and shortness of breath). In PD, higher doses of levodopa are associated with increased risk of motor and non-motor complications, which are notable limitations for longterm therapy. Their occurrence is associated with intermittent levodopa delivery and consequent fluctuating plasma levels. These issues can be offset using lower levodopa doses where possible, incremental dose increases, and combinations of levodopa with other pharmacological agents. OFF episodes in PD can be caused by gastroparesis and/or by Helicobacter pylori infection, which delays delivery of levodopa. These issues can be addressed using new formulations for continuous intrajejunal administration. In addition, pen injector, intranasal, and inhaled dosing systems have been studied and may provide relief via non-intestinal routes. Other approaches include deep-brain stimulation, which is effective but is restricted by costs and potential adverse events. This report presents the highlights of a satellite symposium held at the 14th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD™ 2019), Lisbon, Portugal, which discussed the nature of OFF episodes in PD, associated risk factors and the potential of current and future treatments to effectively manage them and increase ON time.
OKUL ÖNCESİ ÖĞRETMENLERİNE YÖNELİK İNOVATİF DÜŞÜNME EĞİLİMİ ÖLÇEĞİNİN GELİŞTİRİLMESİ
Authors: BİLİR Büşra , AKBAŞ Ufuk , DARICA Nilüfer
Published: January 2023

Çalışmanın amacı okul öncesi öğretmenlerine yönelik inovatif düşünme eğilimi ölçeğini geliştirmektir. Araştırmanın modeli temel araştırma olarak planlanmıştır. Araştırmada yer alan katılımcılar, Türkiye’de resmi ve özel anaokullarında çalışan\çalışmayan 787 öğretmendir. Geliştirilen ölçeğin ölçüt bağıntılı geçerliğini test etmek için “Bireysel Yenilikçilik Ölçeği” ve “Değişime Direnç Ölçeği” kullanılmıştır. Verilerin analizinde açımlayıcı faktör analizi (temel eksenler), doğrulayıcı faktör analizi, Spearmen sıra farkları korelasyon kat sayısı, iç tutarlılık anlamındaki güvenirlik için de Cronbach Alfa kat sayısı hesaplanmıştır. Çalışmanın sonucunda 10 maddeden oluşan tek boyutlu bir ölçek geliştirilmiştir. Varyansın %38’ini açıklayan ölçeğin Cronbach α kat sayısı .85’tir. Doğrulayıcı faktör analizi sonuçları model–veri uyumunun sağlandığını göstermektedir (CMIN/DF=2.41, CFI=.98, GFI=.96, NNFI=.97 ve RMSEA=.06) Ölçekten alınan puanlar ile Bireysel Yenilikçilik Ölçeği puanları arasında pozitif yönde orta düzey (.67), Değişime Direnç Ölçeği ile ise negatif yönde orta düzey (-.31) korelasyonlar elde edilmiştir. 14 gün arayla gerçekleştirilen uygulamalardan elde edilen puanlar arasında .92 (p
ÇEVRİMİÇİ ORTAMDA ÖĞRENCİLERİN DERSE KATILIMLARINI VE DERSTE GEÇİRDİKLERİ SÜREYİ ETKİLEYEN FAKTÖRLERİN İNCELENMESİ
Authors: ÖZAYDIN ÖZKARA Betül , TONGUÇ Güray
Published: January 2023

Öğrencilerin derste var olması ya da kayıtlı olan dersleri takip etmesi olarak nitelendirilen katılım kavramı uzaktan eğitim ortamında son derece önemlidir. Katılımı etkileyen farklı faktörler olduğu görülmektedir. Bu faktörler arasında öğretmen, öğretim yöntemi, öğrencilerin bireysel özellikleri, ders süresi gibi ögeler bulunmaktadır. Katılımının ise öğrenci başarısı, performansı ve dersi bırakması gibi önemli alanları etkilediği görülmektedir. Bu çalışma pandemi döneminde zorunlu olarak uzaktan eğitim ile ders almak durumunda kalan öğrencilerin online ders platformundaki kayıtlarının incelenerek, derslere katılımları ile ilgili eğilimlerini belirlemeyi amaçlamaktadır. Öğrencilerin genel katılım eğilimleri belirlenirken derste kalma süreleri, ders, bölüm, cinsiyet ve dersin sunum şekli değişkenlerine göre incelenmiştir. Derse gecikme süresi ile derste kalma süresi arasında ilişki olup olmadığı araştırılmıştır. Araştırma sonucunda ilk haftalarda derslere katılımın daha fazla olduğu, ilerleyen haftalarda katılım sayısının hep daha düşük kaldığı görülmüştür. Bölüme göre katılım sürelerinin farklılık gösterdiği Hukuk, Maliye ve Tarım Makineleri bölümlerinde okuyan katılımcıların uzaktan eğitim derslerinde uzun süre kalmadıkları görülmüştür. Cinsiyete göre katılım süresi değişmezken, senkron olarak devam eden TBTK derslerinde katılım süresinin, video takibi olan derslere göre daha uzun sürdüğü belirlenmiştir. Öğrencilerin derste kalma süresi ile derse gecikme süresi arasında orta düzeyde ve negatif yönde anlamlı bir ilişki olduğu görülmüştür. Çalışma sonunda öğrencilerin katılımının ilerleyen haftalarda azalmaması için bu konunun nedeninin belirlenmesi, farklı derslerde yeni çalışmaların gerçekleştirilmesi önerilmektedir.
Effect of different methods for estimation of evapotranspiration and water deficit in soil on the growth rates of conilon clonal coffee
Authors: Gaspar Schwan Matheus , Brioschi Andreão Gabriel , Carolo Freitas Maria Eduarda , Steill de Oliveira Pedro Henrique , Fialho dos Reis Edvaldo
Published: January 2023

The water deficit is considered one of the main problems in coffee culture around the world. As a way to get around this problem, producers all over the world adopt the practice of irrigation. However, in the most cultivated areas, a rational irrigation management is not carried out, resulting in excessive or insufficient applications. Based on this, the present work aimed to evaluate the effect of different methods of evapotranspiration estimative and water deficit levels on the growth rates of the clonal conilon coffee. The experiment was conducted in a greenhouse, in a 2 x 3 factorial scheme with the factor evapotranspiration in 2 levels (Penman-Monteith (PM) and Hargreaves & Samani (HS), and the factor water deficit in 3 levels (80%, 50% and 30% of Evapotranspiration of Reference (ETo)) in a completely randomized design. From the results obtained, it was observed that the evapotranspiration estimation method and the water deficit levels had an effect on the growth rates and free assimilation rate of the clonal conilon coffee tree, with the highest growth values in plants irrigated with 80% of ETo by the HS method, and higher assimilation values in plants irrigated with 80% of ETo by the PM method.
Hand washing and hand hygiene in medical practice and day to day life
Authors: Bhattacharya Sayan
Published: January 2023

Hand washing and hand hygiene are very important things to remember in the hospital practice as well as daily life. Hand hygiene can be performed by soap or hand sanitizer. Hand hygiene can lead to drastic reduction in transmission of infections and also drug resistant bugs, and is thus also a good way to combat AMR or antimicrobial resistance in the community as well as in hospital setting. Hand hygiene can be maintained by hand washing or hand scrubbing, and both these things are important, depending on the hospital setting. Hand wash can be social, surgical and antiseptic. Hand hygiene can also be made more popular in the masses by a number of methods and educational activities. Compliance to hand hygiene among people is not always very great, even among the healthcare providers, and this should be a matter of concern. Hence hand hygiene assumes some importance, and is now considered a "do-it yourself vaccine". This topic is discussed less but is very important.
Association between vaginal microbiota dysbiosis with asymptomatic UTI in pregnant woman and adverse pregnancy outcome- A case report
Authors: Swarna S. R. , Vidyameena R , Bharathi T , Jeyakumari D
Published: January 2023

The vaginal microbiota dysbiosis [Bacterial vaginosis (BV)] is a condition in which the predominant Lactobacillus spp is replaced by anaerobic bacteria like and in the women of reproductive age group due to several factors. The women with BV are at a greater risk of acquiring urinary tract infection (UTI). The association of bacterial vaginosis and asymptomatic UTI in pregnant women pose risk for both mother and foetus. Here, a case of adverse pregnancy outcome in pregnant woman with BV and asymptomatic UTI is reported.
Abdominal examination: Invaluable clinical findings and their interpretations
Authors: Bhattacharjee Prosanta Kumar
Published: January 2023

A thorough history, which may continue till the end of the consultation, helps the clinician understand the possible disease condition, its severity, and the overall physical & mental status of the patient. Physical examination, which practically starts as soon as the doctor meets the patient, builds upon these observations. After completing the general examinations attention should be directed to the examination of all the systems with special emphasis on the system related to his complaints i.e., an abdominal examination in case the patient has abdominal complaints. Assimilation of the clinical observations will enable one to arrive at a probable diagnosis.
A comparative study of college students’ attitudes before and after the introduction of Fuzhou tea-picking opera into course
Authors: Liu Fen , Manoharan Pravina , Li Wen
Published: January 2023

This paper takes the music class of Fuzhou Preschool Normal College, Jiangxi Province, China as a case study to analyze the different attitudes of students to the traditional Chinese opera—Fuzhou tea-picking opera which has been introduced into the music class of the school, thus affecting the cultural inheritance effect. A total of 150 non-music major local college students were selected from three classes to carry out the music course inheritance practice for four months in Fuzhou Preschool Normal College. This study was divided into three stages, (a) student assessment, (b) teaching the lesson, (c) feedback and assessment. The aim of this study was to study the perceptions of students from Fuzhou Preschool Normal College, Jiangxi Province, China towards the art from of Fuzhou tea-picking opera, and to explore the factors affecting the learning attitudes of these students. Mixed-methods design was employed within the study. The study found that the implementation of the course significantly improved students’ positive attitude towards Fuzhou tea-picking opera. The implementation of the course played a positive role in promoting the inheritance of the tea-picking opera. Although this is a study on the inheritance of traditional Chinese music course, the ideas of course design and research results are applicable to other traditional Chinese music, and even to other countries which have needs for the inheritance of traditional music.
White matter alterations in amnestic mild cognitive impairment: a tract-based spatial statistics study
Authors: ÇAVUŞOĞLU Berrin , ADA Emel , EMEK SAVAŞ Derya Durusu , YENER Görsev
Published: January 2023

Purpose: To compare white matter (WM) structural alterations between the subjects with amnestic mild cognitive impairment (MCI) which is a transitional state to Alzheimer's Disease (AD) and healthy elderly controls.

Methods: Diffusion tensor imaging (DTI) scans of 20 subjects with amnestic MCI and 20 healthy control groups who are matched by age, gender, and education with the MCI group between 2011 and 2016 were examined by in this retrospective study. WM structural integrity was analyzed using tract based spatial statistics (TBSS) for voxel-based differences in fractional anisotropy (FA) between the two groups.

Results: Fractional anisotropy was found significantly lower in the forceps minor, the body and genu of the corpus callosum, the right anterior thalamic radiation, the right cingulum, the right inferior fronto-occipital fasciculus, the right superior longitudinal fasciculus, and the right superior corona radiata in the MCI group than the control group.

Conclusion: TBSS analysis is a promising method to examine structural WM integrity. These findings suggested that the DTI measurements may be useful for the detection of preclinical changes in AD.
Bir Üniversite Hastanesi Psikiyatri Kliniğinde Elektrokonvülsif Terapi Uygulanmış Hastaların Sosyodemografik ve Klinik Özelliklerinin Retrospektif Olarak İncelenmesi
Authors: TIRAŞ İrem , SOĞUCAK Suna , ERDOĞAN Ali , KULAKSIZOĞLU Burak
Published: January 2023

GİRİŞ VE AMAÇ:Bu çalışmada bir üniversite hastanesi psikiyatri kliniğinde yatarak tedavi gören hastalarda elektrokonvülsif terapi (EKT) uygulamaları ile ilgili sosyodemografik ve klinik özelliklerin ortaya koyulması amaçlanmıştır YÖNTEM VE GEREÇLER:1 Ocak 2014 – 31 Aralık 2019 yılları arasında yatarak tedavi gören 3589 hastadan EKT uygulanan 301 hasta çalışmaya dahil edilmiştir. Hastaların sosyodemografik ve klinik özellikleri retrospektif olarak değerlendirilmiştir. BULGULAR:Kliniğimizde 6 yıllık dönemde yatarak tedavi gören 3589 hastadan 301’ine (%8,3) EKT uygulandığı saptandı. Hastaların 198’i (%65,8) kadın, 103’ü (%34,2) ise erkekti. Hastalara ortalama 8,64±2,43 seans EKT uygulandığı saptandı. Hastaların %87,7’sinin tam veya kısmi fayda gördüğü %12,3’ünün ise hiç fayda görmediği saptandı. EKT uygulamasının en sık duygudurum bozukluğu tanısı almış hastalara (%77,4), ikinci sıklıkta psikotik bozukluğu olan hastalara (%16,9) yapıldığı görüldü. Hastaların 44’ünde (%14,6) komplikasyon meydana geldiği ve bu komplikasyonların en sık konfüzyon, baş ağrısı ve unutkanlık olduğu görüldü. TARTIŞMA VE SONUÇ:Bu çalışma EKT’nin etkili, güvenilir ve yan etki riski oldukça düşük bir tedavi olduğunu göstermiştir.
48,XY,+7,+21 AND 47,XX,+16 FETAL KARYOTYPES IN A CASE WITH RECURRENT PREGNANCY LOSS
Authors: KOCABEY Mehmet , BORA Elçin , ERÇAL Murat Derya , ÇANKAYA Tufan
Published: January 2023

Early pregnancy loss is the outcome of approximately 10% of clinically recognized pregnancies and chromosomal abnormalities are the underlying reason in 50%. In this report we discussed aneuploidy mechanisms and management options based on a couple with recurrent aneuploidies. Thirty-five-year-old female was referred with spontaneous abortion. Quantitative Fluorescent PCR was consistent with trisomy 21 but karyotyping revealed double trisomy of 48,XY,+7,+21. During follow-up, another abortion was diagnosed as 47,XX,+16. Peripheral blood analysis revealed a borderline mosaic 46,XX[95]/45,X[5] karyotype. Her physical examination was normal but abdominal ultrasonography revealed accessory spleen and double ureter in left kidney. We excluded Robertsonian translocations, structural aberrations or trisomic mosaicism as a cause but the borderline 45,X mosaicism may be the triggering factor by decreasing oocyte reserve. Presence of urinary malformation indicates that genitourinary mosaicism may be higher, although ovarian biopsy cannot be performed to determine it. Genetic counseling is vital in management of such cases.
Paraservikal Blok Altında Yapılan Düşük Basınçlı Endometrial Biyopsilerde Başarısızlık Nedenlerinin Araştırılması
Authors: ARI Sabahattin Anıl , ŞENKAYA Ayşe Rabia , KARACA İbrahim , ÖZTEKİN Deniz
Published: January 2023

Amaç

Ofis şartlarında uygulanması sebebi ile popüler hale gelen pipelle endometrial biyopsi sonrası histopatolojik tanı için yeterli materyal elde edilememesi tekniğin olumsuz yönü olarak öne çıkmaktadır. Çalışmanın amacı pipelle biyopsi başarısızlığının nedenlerini ortaya koymak olarak belirlenmiştir.

Gereç ve Yöntem

İzmir Bakırçay Üniversitesi Kadın Hastalıkları ve Doğum Anabilim Dalı’nda 2019-2022 yılları arasında pipelle biopsi işlemi uygulanan olgular planlanan retrospektif çalışmaya dahil edilmiştir. Belirlenen olguların yaş, boy, kilo, vücut kitle endeksi, gebelik ve doğum sayıları ile doğum tipleri, işlemin tıbbi gerekçesi, işlem öncesi endometrial duvar kalınlıkları, ek hastalıkları, biyopsi başarısızlık nedenleri kaydedilmiştir.

Bulgular

Çalışmaya 317 hasta alınmıştır. Olguların median yaşı 45 (min: 35 maks:88) olarak saptanmıştır. Ortalama VKI 25,06 (±3,7) olarak bulunmuştur. Materyal alınabilen 315 hastanın 266’sına (%84,4) histopatolojik tanı konulmuştur. 49 (%15,6) hastaya materyal yetersizliği nedeni ile histopatolojik tanı konulamamıştır. Tek değişkenli lojistik regresyon analizinde ileri yaş (OR 0,83, %95 CI 0,79-0,88, p=0,001), PMVK endikasyonu (OR 20,8, %95 CI 10-43,4, p=0,001), endometrial kalınlığın
Galactosemia: Not To Be Missed Cause of Neonatal Jaundice
Authors: AKYILDIZ Can , ÜÇÜNCÜ EGELİ Tuğba , ARMAĞAN Coşkun , AYDOĞAN Ayça
Published: January 2023

A case representing neonatal jaundice that includes direct and indirect hyperbilirubinemia was diagnosed with classical galactosemia. Even though she was initially approached as a neonatal sepsis case, after the cessation of her milk consumption, jaundice resolved, and the diagnosis was made and supported by additional diagnostic tools. It has been shared to emphasize the importance of assessment and urgent management of the disease during the neonatal period.
Diagnosing Soft Skills in Primary School Students within the Context of the New Ukrainian School Reform
Authors: Linnik Olena
Published: January 2023

The paper presents findings of the study conducted on soft skills (transversal skills) in Ukrainian primary school students. The study sample encompasses students representing 150 schools of various types, including experimental schools involved in piloting of the new State Standard of Primary Education. Six students were randomly selected among third graders (aged 8-9) from each school. The study employed such methods as case study, observation, content analysis and survey. Their combination allowed for a comprehensive investigation of primary school students’ soft skills.
The findings have shown that students’ best-developed skills are those belonging to personal and social domains, namely collaboration and copying with emotions. The weakest skills are related to cognitive domain and include critical and systemic thinking, reading comprehension, ability to logically argue for one’s position. Students in pilot schools have revealed certain advantage over other students in such skills as ability to articulate thoughts orally and in writing, creativity, initiative, collaboration, and problem-solving.        
The study of the formation of cross-cutting skills of students was carried out using the case method, observation method, content analysis and questionnaires.
To determine the level of formation of each end-to-end skill, a methodology was developed, which was based on taking into account the results of the group's performance of both tasks (cognitive and creative) and expert observations of the implementation process.
The Technology of Forming the Professional Culture of Future Teachers: from Reflection to Creativity
Authors: Halchenko Viktoriia , Skoryk Tamara , Bartienieva Iryna , Nozdrova Oksana , Shtainer Tetiana , Snyatkova Tetyana
Published: January 2023

The authors devoted their article to the theoretical study of the formation of children's personal and collective culture in the training of future teachers. In particular, we studied the combination of neuropsychological and cultural-educational aspects in the formation of personal and collective culture as an acquired psychological structure based on the nature-defined deep functions.
The aim of the article was a theoretical analysis of related neuroscientific and educational approaches, formulation of components of professional culture of future educators on the basis of this analysis and development of the author's comprehensive program "The wheel of professionalism of a future teacher". To achieve this goal, the authors used theoretical methods of systematic analysis of the literature, comparison, extrapolation of pedagogical provisions to the neuroscientific plane; structuring and systematization of methodological provisions (components of professional culture of future educators). Among the empirical methods - explication and creative development of didactic material (integrated program) and elements of sociological research (survey) to find out the students' satisfaction with the implemented program.
The relevance of the article lies in the significant discrepancy between the content of higher pedagogical education of future educators (particularly in Ukraine) and the reality of pedagogical activity, which does not take into account the general cognitive imitation and imitative mechanisms of learning culture.
As a result, the neurocognitive and pedagogical reasoning for the development of the program was carried out. We also identified the main criteria for the formation of professional culture (spiritual-creative, cognitive, motivational-value, reflexive-perceptive, instrumental) and modeled a comprehensive program of formation of the basics of professional culture of future educators of educational institutions, which consists of training work on each of the components. The main result is the materialization of the program itself and the determination of a high degree of satisfaction with the students among whom it was implemented.
Significance of the article. The formulated patterns of formation of professional culture and development of the culture of students on the principle of imitation are universal, and each of the above components is illustrated by specific practical and activity material, which may serve as recommendations for improving both the formation of future educators, and educational work in a preschool institution.
Neuro-Pedagogical Aspects of Forming the Professional Competence of Elementary School Teachers and Their Interaction with Students
Authors: Nikulochkina Olena , Теslenko Tetiana , Kokhanko Oksana , Sevastiuk Mariana , Yankovska Inna , Teletska Liudmyla
Published: January 2023

It was found that the concept of modernization of Ukrainian education, especially primary education in the reform "New Ukrainian School", puts forward new social requirements for school education, requires the introduction of innovative learning technologies in the educational process, the basis of which is ultramodern teaching methodology, progressive didactic tools, psychological and neuro-pedagogical theories.
Justified the use of innovative technologies as a means of forming professional competence, which is associated with a rejection of stereotypes in education, goes beyond existing standards of education and personal development of the student; creates new standards for personal, creative, individual focus of the teacher, allows the application of new neuro-pedagogical technologies.
The most effective innovative methods of teaching and professional development of teachers of junior classes of the New Ukrainian school, created taking into account the achievements of neuro-pedagogy are highlighted, namely: game, problem-oriented, team-oriented, project-based methods, the portfolio method, information and communication technologies.
Activation of cognitive activity of students, taking into account their individual neuro-didactic characteristics affecting the degree of their involvement in the educational process was investigated.
Force feedback use when moving load by a pair of manipulators
Authors: Sorokin N.F. , Gavryushin S.S.
Published: January 2023

The paper considers problem of joint cargo transfer by a pair of manipulators. In accordance with the compliant control paradigm, a solution is proposed that includes the force feedback counteracting the increase in forces in the load-manipulator system. Using tensor representation and screw calculus, the one-dimensional problem is generalized to the multidimensional case. Computer model of the system under study was built and computational experiments were carried out using the Gazebo robotic simulation package. The results obtained confirm the prospects of the position force approach to solving the group control problems.
Identificación de proteínas de unión al ácido salicílico en el transcriptoma de Citrus latifolia infectado con Candidatus Liberibacter asiaticus
Authors: Santillán-Mendoza Ricardo , Rodríguez-Peralta Erick Daniel , Estrella-Maldonado Humberto José , Rodríguez-Quibrera Cynthia Guadalupe , Matilde-Hernández Cristian , Adame-García Jacel , González-Oviedo Nelly Abigail , Flores-de la Rosa Felipe Roberto
Published: January 2023

La producción de limón persa (LP) es importante para el estado de Veracruz, México. Sin embargo, se ve afectada por el Huanglongbing (HLB), causada por Candidatus Liberibacter asiaticus (CLas), un patógeno biotrófico obligado. LP presenta un cierto nivel de tolerancia al HLB, por tanto, resulta relevante estudiar su respuesta de defensa mediada por ácido salicílico (SA). Tres genes con capacidad de participar en la ruta de respuesta por SA, conocidos como NtSABP, han sido identificados en Nicotiana tabacum; sin embargo, se desconoce la presencia y actividad de dichos genes en LP en respuesta al HLB. En este trabajo se identificaron proteínas homólogas tipo SABP en el transcriptoma de LP y se determinó su grado de expresión diferencial durante la infección con CLas. Se realizó un tBLASTn en el transcriptoma de LP usando como modelo secuencias de las proteínas SABP de cinco diferentes especies, incluyendo N. tabacum. Se reconstruyó y comparó el modelo 3D de las proteínas SABP de N. tabacum y C. latifolia. Con los análisis de tBLASTn, la reconstrucción filogenética y la estructura tridimensional se logró identificar el homólogo directo de cada gen NtSABP en LP. Interesantemente, los genes ClSABP1, ClSABP2 y ClSABP3 mostraron represión en plantas infectadas con CLas. En LP hay al menos un homólogo para cada gen NtSABP. Durante la infección por CLas, estos genes se encuentran ligeramente reprimidos.
Management of Dry Root Rot of Mungbean Caused by Macrophomina phaseolina Through Organic Amendments, Plant Extracts and Bio-agents
Authors: . Anupriya , Chawla Nitin , Ghasolia M.K. , . Prahlad , Bagri R.K. , Godika Shailesh , Ghasolia R.P.
Published: January 2023

Background: Mungbean [Vigna radiata (L.) Wilczek], commonly recognized as green gram, is the most significant and advanced pulse crop grown in Rajasthan. Dry root rot is one of the important diseases of mungbean caused by M. phaseolina, which is responsible for 30 to 40 per cent disease incidence with huge yield loss during seedling to mature stages. Methods: The experiments were conducted for two consecutive years during kharif 2020 and 2021 for managing the disease through organic amendments, plant extracts and bio-agents viz., Trichoderma harzianum (10 g/kg seeds), garlic extract (15%), neem cake (0.5 t/ha) and mustard cake (0.5 t/ha) alone and in combinations through seed as well as soil applications. Result: Our investigations cleared that the maximum disease reduction and highest seed yield were reported by treating the seeds with T. harzianum @10 g/kg seed + soil application of mustard cake @ 0.5 t/ha followed by seed treatment with T. harzianum @ 10 g/kg seed + soil application of neem cake @ 0.5 t/ha. In view of consumer health, present findings may be helpful for growers to get extra benefits by producing organic mungbean.
Revisión de las políticas de Costa Rica hacia una agricultura climáticamente inteligente (1990-2020)
Authors: Montenegro Hidalgo Enrique , Rodríguez Lizano Víctor , Rodríguez Barillas María Fernanda , Losilla Solano Luis Vinicio
Published: January 2023

A nivel internacional, el desarrollo de las políticas ambientales durante las últimas cuatro décadas se ha dado de forma consecutiva a través de épocas que sugieren una ruta a seguir para transformar la agricultura hacia una agricultura climáticamente inteligente. Sin embargo, surge la pregunta de ¿Cómo han evolucionado las políticas agropecuarias y ambientales de Costa Rica con respecto al marco temporal conceptual que se ha presentado internacionalmente en las últimas décadas? Para responder a esta interrogante, este manuscrito identifica un marco temporal internacional de políticas públicas ambientales para el periodo comprendido entre los años 1990 y 2020 que es contrastado con la evolución de la política agropecuaria y ambiental de Costa Rica para dicho periodo. Los hallazgos muestran que sí existe concordancia en el desarrollo de algunas políticas agroambientales con el marco temporal internacional desarrollado. Esto ha propiciado el establecimiento de un marco institucional y jurídico que le han permitido a Costa Rica construir una imagen país con una orientación de preocupación por el ambiente que es reconocida a nivel internacional. No obstante, esto no ha sido así en todas las ocasiones, ya que algunas políticas han sido desarrolladas en respuesta a presiones y tendencias internacionales que no responden a la época de desarrollo ambiental propia. Esto evidencia la necesidad de realizar mayores esfuerzos en busca de una mejor coherencia en el desarrollo de políticas agropecuarias y ambientales que permitan la construcción de una agenda de largo plazo en aras de procurar una transformación haca una verdadera Agricultura Climáticamente Inteligente.
Percepciones de las personas productoras de café ante el impacto de COVID-19 en Los Santos, Costa Rica
Authors: Díaz Porras Rafael , Delgado Ballestero Antonio , Picado Umaña Wilson , Madigosky Stephen
Published: January 2023

La crisis sanitaria provocada por COVID-19 ha generado una serie de retos para distintos sectores productivos a nivel mundial y Costa Rica no fue la excepción. Este estudio mide las percepciones acerca del impacto provocado por COVID-19 en el sector cafetalero, el cual ha tenido que adaptarse a las nuevas limitaciones planteadas por dicha crisis, sopesar las fluctuaciones en los mercados internacionales y los cambios en las políticas migratorias. El objetivo es indagar en las principales preocupaciones de las personas productoras de café ante la crisis. Para ello, se realizó una encuesta que evaluó el grado de preocupación de las personas caficultoras sobre temas relativos a la producción y al desarrollo del sector, concentrando su atención en las condiciones productivas y laborales actuales y futuras. La encuesta se llevó a cabo en la Zona de Los Santos, formada por los cantones de Dota, Tarrazú y León Cortés, entre septiembre y octubre de 2020, previo a la temporada de cosecha. Las 119 personas productoras fueron seleccionados mediante la técnica de “bola de nieve”. Dicha encuesta estuvo compuesta por preguntas cerradas en una escala de Likert de cinco opciones y 34 preguntas, cuyas respuestas daban acuerdo o desacuerdo con las afirmaciones planteadas. Mediante el análisis de factores, los resultados indican que, entre las principales preocupaciones de las personas caficultoras, se encuentran el temor al aumento en los costos de producción debido a las regulaciones sanitarias, el comportamiento de los mercados del café y el posible faltante de mano de obra necesaria para la cosecha debido a las restricciones migratorias.
THE TRANSFORMATION OF RETAIL CREDIT FINANCING IN THE WAKE OF THE CRISES IN HUNGARY
Authors:   Ph.D., Associate Professor, Keleti Károly Faculty of Business and Management, Óbuda University, Budapest, Hungary, Csiszárik-Kocsir Ágnes
Published: January 2023

The money abundance that preceded the 2008 crisis brought about a number of distortions in the value judgements of economic actors and their attitudes towards money. Unlimited liquidity generated a huge supply of credit, which all economic players exploited beyond their means. The crisis-induced downturn caused huge problems in the repayment of loans. Tens of thousands of families and businesses have faced problems in surviving, caused by increased credit burdens. As a consequence, attitudes towards credit changed significantly after the crisis. For the Hungarian households too, excessive borrowing before the crisis caused huge problems. In Hungary, the problem was not only with the volume of credit, but also with its denomination. The proliferation of foreign currency lending and the exchange rate risk that it entailed was a huge challenge for tens of thousands of families, which they could only overcome with state support. The aim of this study is to examine the borrowing of households in Hungary over a number of years, looking in particular at its composition and the types of credit. In this study, the analysis was based on the household stock data of the Hungarian National Bank. The aim of the work is to show the trends and changes in Hungarian household borrowing in the wake of the crises. The analysis reveals the effects of the crises, which can be reduced by increasing financial awareness. The study provides a good basis for strengthening the financial culture of Hungarian households, which areas limit future irresponsible borrowing and provide a good shield against crises in the financial field.
THE INFLUENCES OF BANK-FIRM RELATIONSHIPS IN CREDIT ACCESS OF SMES
Authors:   Ph.D., Department of International Trade and Business, Doğuş University, İstanbul, Turkey, Civelek Mehmet
Published: January 2023

Since many SMEs (small and medium-sized enterprises) lack internal resources, they usually look for external credits that banks are the main providers of. However, most of those businesses’ main concern is to gain credit access since these businesses are not very efficient when minimizing information asymmetries between them and their lenders. Thus, relationship lending that includes close interactions, long-term relationships, and, close ties between SMEs and banks might reduce information asymmetries and might provide easier credit access conditions for SMEs. In this regard, this research aims to investigate the positive association between the length of the relationship, the closeness of communication, the house bank status, and access to bank credit. In line with this selected purpose, the researcher created an online questionnaire and collected data from 479 SMEs operating in Turkey. To examine the specified relationships, the researcher performed Binary Logistic Regression analyses. The results confirm the positive relationships between the variables of relationship lending and access to finance. Therefore, SMEs focusing on socializing and networking activities with banks might receive advantages to gain easier credit access conditions. The reasons for these results might be related to cultural, and executive-firm-specific characteristics, including the structure of society, the sectoral experiences, and the length of doing business, respectively.
Rationale for the Need to Introduce Interactive Cases in the Practice of Training Managers
Authors:   University of Tyumen, Kazantseva Svetlana M.
Published: January 2023

The main purpose of the article is to substantiate the need to change the concept of training managers. On the basis of practical experience, the difficulties that arise when mastering the skills necessary for future professional activity are formulated. The limitations of the applied teaching methods are revealed: cases, business games, discussions and internships. The essence of the new teaching methodology "interactive case" is determined, its technology is described. A demonstration of an example of using an interactive case in the practical work of a teacher is given. The project is implemented by the winner of Master's Program Faculty Grant Competition of the Vladimir Potanin Fellowship Program.
The Russian Traditional Family: Socio-philosophical Analysis and Comprehension Prospects for Preservation and Development
Authors:   Institute of Socio-Political Research — Branch of the Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences (ISPR FCTAS RAS), Rostovskaya Tamara K. , Egorychev Alexander М.
Published: January 2023

The article considers the problems related to the evolution of the Russian traditional family. Scientific directions on this problem are defined; historical stages concerning its development are revealed; the peculiarities inherent in the Russian traditional family and its family relations are revealed. The authors clearly defined their scientific and political position concerning the need to preserve the historical traditional meanings and values inherent in the Russian family and the development of modern family policy on their basis. According to the results of the study, the authors present promising provisions concerning the preservation, strengthening and development of traditional values of the Russian family.
Morphological and agronomical characterization of pineapple plants derived from vitro culture
Authors: Yeo Mohamed Anderson , Gogbeu Dan Gbongue Lucien , Yeo Navigué Abou , Kouakou Tanoh Hilaire , Coulibaly Lacina
Published: January 2023

In Côte d'Ivoire, pineapple occupies a prominent place after the coffee and cocoa binomial in exports. The country has long been the leading producer of smooth Cayenne in the European market. However, this dynamism is hampered by the lack of good quality rejects. To overcome this constraint, various methods of in vitro regeneration of plantlets have been initiated. Micro propagation and somatic embryogenesis allow massive production of plants of good sanitary quality. However, acclimatization of the vitro plants is a critical phase. This study was conducted to assess the growth parameters and success rate of vitro plants during acclimatization, as well as the growth potential of vitro plants in the field. To do so, the plants resulting from micropropagation and somatic embryogenesis were evaluated in greenhouse, shade and field. Plants from the mother suckers were used as controls in the field. After acclimatization, a 98% survival rate of the vitro plants was observed. In the field, the vitro plants behaved differently. The growth parameters of plants from somatic embryogenesis were significantly higher than those from micropropagation and plants from mother suckers. In addition, controlling acclimatization is an important asset for mass disposal of pineapple plants for the renewal of the Ivorian orchard. Thus, to develop pineapple cultivation in Ivory Coast, it would be interesting to use juvenile offspring from vitro cultures, in particular from somatic embryogenesis.
Cultivation and practice of entrepreneurial ability of horticulture students in the perspective of innovation and entrepreneurship
Authors: Yao Zhen , Hou Shu-wang , Wu Li-xue , Zhao Yi-chen , Liu Chun-yan
Published: January 2023

The present study was conducted to explore the entry point of entrepreneurship education by continuously following and investigating the entrepreneurship team of horticulture majors and exploring the integration of entrepreneurship teaching based on the existing professional curriculum and teaching system. We examined the goals of developing a teaching system for horticulture students' entrepreneurial competence training, and we summarized the entry points for horticulture students' entrepreneurial competence training. We discovered that in curriculum design, teachers should pay more attention to leading and engaging students in entrepreneurial thinking, and that entrepreneurial competency training for team students with goals and targets should be provided.
Choosing optimal treatment organisation strategy for unresectable liver cancer: case of Moscow region
Authors:   Federal State Budgetary Institution «National Medical Research Radiological Centre» of the Ministry of Health of the Russian Federation, Kaprin A. D. , Lyadov K. V. ,   Federal State Budgetary Institution «National Medical Research Radiological Centre» of the Ministry of Health of the Russian Federation, Polushkin V. G. ,   Moscow Rehabilitation Center, Kucherov V. V. ,   A. F. Tsyb’s Medical Radiology research center – branch of the Federal State Budgetary Institution «National Medical Research Radiological Centre» of the Ministry of Health of the Russian Federation, Petrosyan A. P. ,   A. F. Tsyb’s Medical Radiology research center – branch of the Federal State Budgetary Institution «National Medical Research Radiological Centre» of the Ministry of Health of the Russian Federation, Khailova Zh. V. ,   A. F. Tsyb’s Medical Radiology research center – branch of the Federal State Budgetary Institution «National Medical Research Radiological Centre» of the Ministry of Health of the Russian Federation, Ivanov S. A. ,   A. F. Tsyb’s Medical Radiology research center – branch of the Federal State Budgetary Institution «National Medical Research Radiological Centre» of the Ministry of Health of the Russian Federation, Majorov K. V. ,   LLC “BEBIG”
Published: January 2023

Introduction: despite quite low morbidity with up to 6 thousand cases per year in Russia, therapy for unresectable liver tumors is based on costly therapy with tyrosine kinase inhibitors or anti-PD‑1L agents thus leading to extremely high costs per life year saved. In the meantime, transaterial radioembolization (TARE)technique is reported to show better outcomes in this patient group compared to conservative treatment and transarterial chemotherapy (TACT). This article researches strategic options for regionwide treatment programs focused on involving TARE in unresectable liver tumors treatment. Methodology. Epidemiological data provided by national cancer report. Systematic review of literature (not meeting PRISMA criteria) was done for TARE vs. TACT and TARE vs. conservative treatment overall survival. Treatment costs were based on current governmental treatment tariffs for Moscow region. Only direct oncology costs were included without possible complications analysis. The final analysis was done for optimistic, pessimistic and moderate expected numbers of patients eligble for TARE. Results. Optimal treatment strategy implies maximum allowable rate of TARE with patients concentration in selected hospitals. For Moscow region (population of 7,6 million people) estimated yearly benefit of this strategy is 309,3 RUB (USD3,4 million USD) and 284 life years saved based on moderate prognosis.
The relationship between the structure of nutrition and chronic non-communicable diseases
Authors:   Al-Farabi Kazakh National University, Kozhabek L.
Published: January 2023

I n t r o d u c t i o n . The article analyzes modern literary sources and scientific ideas devoted to the study of the role of healthy nutrition and the influence of nutrition factors on health. Proper and healthy nutrition is the basis of a high-quality human life, affects health, longevity and performance. Modern nutrition should not only satisfy the physiological needs of a person for nutrients and energy, but also perform preventive and therapeutic functions. Diets based entirely on the consumption of plant products are becoming increasingly popular due to the many claimed health benefits. Numerous studies conducted in recent years indicate that a plant-based diet with a restriction of animal products is accompanied by a lower risk of developing chronic diseases, and in some nosologies contributes to disease control. The goals and objectives of the prevention of healthy eating are to preserve and strengthen the health of the population, prevent diseases caused by inadequate and unbalanced nutrition. M a t e r i a l s a n d m e t h o d s . A review of the literature on the control of food safety, the fullness and balance of nutrition, compliance with dietary regimes. R e s u l t s . With eating disorders, the ability to withstand adverse environmental influences, stress, increased mental and physical exertion sharply decreases. An imbalance of nutrients, vitamins and minerals in the composition of food leads to metabolic disorders and subsequently to disease. D i s c u s s i o n . Rational nutrition is considered as one of the components of “lifestyle medicine”. At the same time, most researchers emphasize the need for large-scale population-based research in this area in accordance with modern principles of evidence-based medicine. C o n c l u s i o n . The results of numerous studies indicate the significant role of nutrition in the development of various diseases, their prevention and treatment. Nutrition is the basis for all metabolic processes of the human body, therefore, a violation of nutrition contributes to the occurrence of the disease. A healthy diet and a healthy lifestyle are the basis of disease prevention.
Relevance of introducing remote surveillance technologies for high-risk patients suffering with cardiovascular diseases during a pandemic Professional burnout of medical nurses: features of generations
Authors:   Astrakhan State Medical University, Department of Public Health and Health with a PDO course, Murzagalieva A. N.
Published: January 2023

The organization of health support for people with cardiovascular diseases during a pandemic requires limiting direct contact with the patient. It is necessary to introduce/improve technologies for remote monitoring of the condition of high-risk patients with the possibility of prompt response in case of deterioration. The purpose of the work – a detailed study of the possibilities of implementing remote technologies for analyzing the condition of high-risk patients with cardiovascular diseases. Methods and materials: a detailed analysis of literature sources concerning remote monitoring of the condition of persons suffering from cardiovascular diseases and being at high risk was carried out. Particular attention is paid to studies conducted during the pandemic. The study of the state of the issue of interest was carried out by analyzing publications in the databases: Cyberleninka, PubMed, Elibrary, ScienceDirect, Springerlink. Results: the trends in the development of modern technologies for remote analysis of the parameters of the functioning of the cardiovascular system, including pulse rate, blood pressure, and electrocardiographic studies, were determined. Particular attention is paid to assessing the possibilities of counseling the patient through remote communication, options for transmitting data on the patient’s condition, methods of emergency communication.