bluuebunny/crossref_metadata_2025 huggingface dataset:
Arabic Sentiment Analysis for ChatGPT Using Machine Learning Classification Algorithms: A Hyperparameter Optimization Technique
Authors: Nasayreh Ahmad , Mamlook Rabia Emhamed Al , Samara Ghassan , Gharaibeh Hasan , Aljaidi Mohammad , Alzu'bi Dalia , Al-Daoud Essam , Abualigah Laith
Published: January 2024

In the realm of ChatGPT's language capabilities, exploring Arabic Sentiment Analysis emerges as a crucial research focus. This study centers on ChatGPT, a popular machine learning model engaging in dialogues with users, garnering attention for its exceptional performance and widespread impact, particularly in the Arab world. The objective is to assess people's opinions about ChatGPT, categorizing them as positive or negative. Despite abundant research in English, there is a notable gap in Arabic studies. We assembled a dataset from X (formerly known as Twitter), comprising 2,247 tweets, classified by Arabic language specialists. Employing various machine learning algorithms, including Support Vector Machine (SVM), Logistic Regression (LR), Random Forest (RF), and Naïve Bayes (NB), we implemented hyperparameter optimization techniques such as Bayesian optimization, Grid Search, and random search to select the best hyperparameters that contribute to achieving the best performance. Through training and testing, performance enhancements were observed with optimization algorithms. SVM exhibited superior performance, achieving 90% accuracy, 88% precision, 95% recall, and 91% F1 score with Grid Search. These findings contribute valuable insights into ChatGPT's impact in the Arab world, offering a comprehensive understanding of sentiment analysis through machine learning methodologies.
BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes
Authors: Alcober-Boquet Lucia , Kraus Nico , Huber Lisa Sophie , Vutukuri Rajkumar , Fuhrmann Dominik C. , Stross Claudia , Schaefer Liliana , Scholich Klaus , Zeuzem Stefan , Piiper Albrecht , Schulz Marcel H. , Trebicka Jonel , Welsch Christoph , Ortiz Cristina
Published: January 2024

17-β-Hydroxysteroid dehydrogenase 13 (HSD17B13) is a lipid droplet protein primarily expressed in the liver hepatocytes. HSD17B13 is associated with the clinical outcome of chronic liver diseases and is therefore a target for the development of drugs. Here, we demonstrate the promising therapeutic effect of BI-3231 as a potent inhibitor of HSD17B13 based on its ability to inhibit triglyceride accumulation in lipid droplets (LDs), restore lipid metabolism and homeostasis, and increase mitochondrial activity in vitro.
Functional asymmetry of the urea transporter UT-B in human red blood cells
Authors: Leifelt Jonas , Dziegiel Morten Hanefeld , Brahm Jesper
Published: January 2024

The kinetics of urea transport in red blood cells was determined by means of a combination of four methods that ensures a high time resolution. In the present study, we disclose that the urea transporter UT-B functions highly asymmetric being channel-like with no saturation under conditions of net efflux and saturable under conditions of net influx and self-exchange in the concentration range 1–1,000 mM (pH 7.2 and 25–38 °C).
Taube Menschen in Deutschland: Mental Health Literacy und Einschätzung der Angebote des psychiatrisch-psychotherapeutischen Versorgungssystems – eine Online-Studie
Authors: Ricke Antonia , Klusmann Hannah , Heinrich Manuel , Haering Stephanie , Blecker Meike Katharina , Knaevelsrud Christine , Schumacher Sarah
Published: January 2024

Hintergrund: Taube Menschen begegnen als sprachliche Minderheit im psychiatrisch-psychotherapeutischen Versorgungssystem zahlreichen Barrieren. Mental Health Literacy (MHL), die für Erkennen, Behandlung und Hilfesuchverhalten bei psychischen Störungen essenziell ist und den Umgang mit Belastungen prägt, wurde bei Tauben Menschen bislang nicht untersucht. Material und Methoden: Taube Menschen (n = 390) wurden online zur MHL und der Einschätzung der Angebote des psychiatrisch-psychotherapeutischen Versorgungssystems befragt. Dafür wurde eine in deutsche Gebärdensprache übersetzte Version des Mental Health Literacy Questionnaire genutzt. Der Einfluss des Spracherwerbszeitpunktes und der Gebärdensprache als natürlicher Erstsprache auf die MHL wurden mithilfe von Welch-Tests und Cohens d untersucht. Ergebnisse: Das durchschnittliche Alter der Teilnehmenden war 32,6 Jahre (SD = 11,0) und ein Großteil (69%) bezeichnete sich als weiblich. In Bezug auf den Ertaubungszeitpunkt wurden 78,7% der Teilnehmenden Taub/schwerhörig geboren und 14,1% sind vor dem vierten Geburtstag ertaubt. Ein früher Spracherwerb (p >0,001) sowie das Erlernen einer Gebärdensprache als Erstsprache (p = 0,02) waren mit einer höher ausgeprägten MHL assoziiert. Die Zufriedenheit mit dem Versorgungssystem bezüglich verschiedener Aspekte (z. B. Eingebundenheit in Behandlung) wurden beschrieben. Diskussion: Die MHL bei Tauben Menschen ist erhöht, wenn ein früher Spracherwerb gegeben ist sowie eine Gebärdensprache als Erstsprache erlernt wurde. Daraus abgeleitet sind gesellschaftliche und gesundheitspolitische Anstrengungen notwendig, um einen frühen Spracherwerb und den Zugang zu Gebärdensprache für Taube Kleinkinder zu ermöglichen. Als zusätzliche Maßnahmen können mögliche Defizite der MHL mit einer erleichterten Zugänglichkeit zu psychischen Gesundheitsinformationen vermindert werden. Dabei könnten die Verfügbarkeit von Informationsmaterialien in Gebärdensprache und die Verbesserung der Ausbildung für Taubes Personal und Gebärdensprachdolmetschende eine wichtige Rolle spielen.
Microdeletion 1p32p31 Presenting with Moyamoya Disease and Incomplete Hippocampal Inversion
Authors: Pires de Oliveira-Sobrinho Ruy , Bispo Luciana Mota , Heleno Julia Lôndero , Rojas Ayala Fernanda Rocha , Reis Fabiano , Vieira Társis Paiva , Steiner Carlos Eduardo
Published: January 2024

Background: The chromosome 1p32p31 deletion syndrome is a contiguous gene disorder with a variable phenotype characterized by brain malformations with or without urinary tract defects, besides neurodevelopmental delay and dysmorphisms. An expanded phenotype was proposed based on additional findings, including one previous report of a patient presenting with moyamoya disease. Case Presentation: The authors report a patient presenting with early neurodevelopmental delay, hydrocephalus, renal malformation, and dysmorphisms. After presenting with a sudden choreic movement disorder, the neuroimaging investigation revealed an ischemic stroke, moyamoya disease, and bilateral incomplete hippocampal inversion. Chromosomal microarray analysis revealed a deletion of 13.2 Mb at 1p31.3p32.2, compatible with the contiguous gene syndrome caused by microdeletions of this region. Discussion/Conclusion: This is the second report of a patient who developed Moyamoya disease and the first to describe bilateral incomplete hippocampal inversion in this microdeletion syndrome.
Hemoadsorption contribution in failing Fontan pediatric heart transplantation
Authors: Pace Napoleone Carlo , Aidala Enrico , Cascarano Maria Teresa , Deorsola Luca , Iannandrea Stefania , Longobardo Annalisa , Bonaveglio Enrico , Zanin Mattia , Peruzzi Licia
Published: January 2024

Background A systemic inflammatory response is triggered in patients undergoing cardiothoracic surgery with cardiopulmonary bypass. This response is particularly evident in pediatric patients, especially if of low weight and after undergoing long cardio-pulmonary by-pass (CPB), and can severely impair surgical result.
Objectives Adsorptive blood purification techniques have been proposed to limit this systemic inflammatory response. To test its efficacy, we added the hemoadsorption filter Jafron HA 380 to CPB in a very compromised pediatric patient who underwent heart transplantation.
Method A 10-year-old single ventricle patient previously treated with Fontan operation was listed for heart transplantation due to the evidence of failing Fontan condition. He experienced many episodes of cardiac arrest and underwent heart transplantation in very compromised general and hemodynamic conditions. The hemoadsorption filter Jafron HA 380 was used for all the duration of CPB and the inflammatory biomarker Interleukin 6 (IL-6) was assayed.
Results Post-operative outcome was uneventful and comparable to that of an elective pediatric heart transplantation. The Interleukin 6 (IL-6) levels showed an impressive post-operative reduction and after 2 days the IL-6 level was comparable with a typical uneventful post-transplant course.
Conclusions The use of hemoadsorption filter can contribute to improve pediatric transplant results especially in very high-risk patients.
Intraneural Ulnar Nerve Ganglion: A Surgical Case Report of a 10-cm-Long Recurring Ganglion Cyst in the Forearm
Authors: Reiser Daniel , Szallasi Arpad , Sagerfors Marcus
Published: January 2024

Introduction: Intraneural ganglions are benign and rare mucinous cysts that originate within peripheral nerves and typically can lead to symptoms and signs of peripheral neuropathy. The most common location is the peroneal nerve, and the second most common location is the ulnar nerve. Case Presentation: We present a case of a 53-year-old man who presented with increasing numbness in the ulnar aspect of the left hand and decreasing hand strength. MRI showed an intraneural ganglion, and as the patient had clinically progressive symptoms, a decision was made for surgical excision. The patient was symptom-free after the procedure and had no neurological deficits. Eighteen months later, the patient contacted us again as his symptoms had returned. A new MRI showed ganglion recurrence. Due to progressive clinical symptoms, another attempt was made to remove the ganglion surgically. Paraffin immunostains excluded other diagnoses like synovial cyst, posttraumatic neuronal cyst, Tarlov cyst, mesothelial cyst, and cystic lymphangioma. At follow-up 3 months postoperatively, the patient was symptom-free and had normal neurological findings. Conclusion: Intraneural ganglion should be considered as a differential diagnosis of a cystic mass close to a nerve. For surgery, we favor less radical methods, such as simple decompression.
Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma
Authors: Walach Margarete Teresa , Nitschke Katja , Groß-Weege Matthias , Großhans Johannes , Wildner Lukas , Pause Luca , Jarczyk Jonas , Wessels Frederik , Neuberger Manuel , Kowalewski Karl-Friedrich , Kriegmair Maximilian Christian , Popovic Zoran V. , Gaiser Timo , Worst Thomas Stefan , Nuhn Philipp
Published: January 2024

Introduction: The aim was to evaluate the prognostic value of altered Cyclin A2 (CCNA2) gene expression in upper tract urothelial carcinoma (UTUC) and to assess its predictive potential as a prognostic factor for overall survival (OS) and disease-free survival. Methods: 62 patients who underwent surgical treatment for UTUC were included. Gene expression of CCNA2, MKI67, and p53 was analyzed by quantitative reverse transcriptase polymerase chain reaction. Survival analyses were performed using the Kaplan-Meier method and the log-rank test. For Cox regression analyses, uni- and multivariable hazard ratios were calculated. Spearman correlation was used to analyze correlation of CCNA2 expression with MKI67 and p53. Results: The median age of the cohort was 73 years, and it consisted of 48 males (77.4%) and 14 females (22.6%). Patients with high CCNA2 expression levels showed longer OS (HR 0.33; 95% CI: 0.15–0.74; p = 0.0073). Multivariable Cox regression analyses identified CCNA2 overexpression (HR 0.37; 95% CI: 0.16–0.85; p = 0.0189) and grading G2 (vs. G3) (HR 0.39; 95% CI: 0.17–0.87; p = 0.0168) to be independent predictors for longer OS. CCNA2 expression correlated positively with MKI67 expression (Rho = 0.4376, p = 0.0005). Conclusion: Low CCNA2 expression is significantly associated with worse OS. Thus, CCNA2 might serve as a potential biomarker in muscle-invasive UTUC and may be used to characterize a subset of patients having an unfavorable outcome and for future risk assessment scores.
An Inquiry-Based Learning Module for General Mathematics: Its’ Development and Evaluation
Authors: Lumabit April Mae C. , Sagge, Jr. Roberto G.
Published: January 2024

The goal of this developmental research was to develop and evaluate an Inquiry-Based Learning Module for General Mathematics for Grade 11 students. It was conducted at two secondary schools with one hundred forty-one Grade 11 students and four mathematics teachers as respondents. The study used the descriptive-evaluative method to describe and evaluate the developed module using the questionnaire-checklist in gathering data. The development of the module utilized the modified model by Borg and Gall, which includes the inspection of the curriculum guide, planning, product development and designing assessment instrument, development of the instructional materials, validation of mathematics teachers and experts, revisions, limited trial to students and the finalization of the instructional material. The respondents were asked to evaluate the worktext on the following aspects:  objectives, contents, activities, style and presentation, organization, creativity, and assessment. The result shows that the developed module with respect to objectives, contents, activities, style and presentation, organization, creativity, and assessment was verbally interpreted as "very good". Generally, the respondents evaluated the developed module as "very good". This means that the developed module very satisfactorily meets the standards with very few revisions. Thus, the researcher recommends the use of the developed inquiry-based learning module for General Mathematics for Grade 11 teachers and students to facilitate teaching and learning.
Emmanuelles tropicais: apropriações brasileiras, conservadorismo e transgressão
Authors: Monteiro Tiago José Lemos , Cánepa Laura Loguercio
Published: January 2024

A proposta deste artigo é discutir um período crítico para a indústria cultural brasileira no processo de urbanização e modernização do país (a década de 1970) por meio da observação dos modos de circulação de um grupo de filmes que dialogou com tendências internacionais do cinema por meio da prática do “similar nacional”. No caso, interessa à pesquisa os filmes brasileiros derivativos do clássico do cinema erótico Emmanuelle, de 1974: Emmanuelle Tropical (1977), de J. Marreco; Emmanuello...o belo (1978), de Nilo Machado; e A Filha de Emmanuele, dirigido em 1980 por Osvaldo de Oliveira.
Os realismos do true crime: estratégias narrativas dos episódios-piloto da série ficcional (HBO) e da série documental (Netflix) The Staircase
Authors: Fontoura Marina Burdman da , Helich Tatiana , Figueiredo Vera Lúcia Follain de
Published: January 2024

Recentemente, duas produções audiovisuais foram lançadas no serviço de streaming, inspiradas no caso real do julgamento do romancista americano Michael Peterson, acusado de matar a esposa Kathleen Peterson: a série The Staircase, pela HBO, em 2022, e a série documental de mesmo nome, pela Netflix, em 2018. A partir dos episódios-piloto, tenciona-se pensar a construção narrativa de ambas, entendendo que se utilizam de recursos das linguagens documental e ficcional para referenciar o crime e gerar no espectador um efeito de realidade. Para isso, objetiva-se refletir sobre manifestações contemporâneas do realismo e como elas, ao lado do uso de estratégias narrativas do gênero policial, tornam-se formas de engajar o espectador, que assume um papel de detetive na trama. Pretende-se, assim, indagar como cada um dos pilotos adota pontos de vista diferentes, fazendo uso das lacunas deixadas pelo caso real para construir suas próprias versões sobre o crime.
Copiando O Homem que Copiava: intertextualidades, fragmentos e autoria
Authors: Silva Eduardo Miranda
Published: January 2024

Este artigo aborda a questão da cópia no âmbito do debate acerca de noções como autoria, originalidade e perda da centralidade da figura do autor a partir da descoberta da existência de uma adaptação não autorizada envolvendo o filme indiano Currency, de 2009, dirigido pelo cineasta Swathi Bhaskar, e o longametragem brasileiro O Homem que Copiava, de 2003, roteirizado e dirigido por Jorge Furtado. A partir da retomada de questões intertextuais contidas na obra de Furtado e da conhecida relação do diretor com o cânone literário, pretende-se discutir o fragmento e a montagem contemplados na obra brasileira. Também se objetiva analisar a mise en abyme, que extrapola o circuito ficcional diante da reação irônica e lúdica de Jorge Furtado ao saber de um copiador que plagiou seu filme sobre um copiador.
#ANJO: Explorando a produção e o consumo de memoriais a vítimas de crimes reais em plataformas de redes sociais
Authors: Biadeni Bianca Souza , Castro Gisela Grangeiro da Silva
Published: January 2024

Este artigo investiga a produção de narrativas em homenagem às vítimas de crimes, compartilhadas em plataformas digitais. Debateu-se o consumo simbólico da morte e do luto por meio de produtos comunicacionais, mobilizando no referencial teórico autores dos estudos da midiatização e do consumo. Utilizou-se a Análise de Conteúdo e a Análise Discursiva Comunicacional para examinar três perfis memoriais dedicados à mesma pessoa, com o objetivo de discernir os processos de produção de conteúdo e avaliar as dinâmicas de interação nesses espaços, bem como as possíveis motivações subjacentes. Compreender essas produções como um componente integral da linguagem social contemporânea nos permite pensar os produtos e processos comunicacionais que fazem parte das inquietantes questões do mundo em que vivemos.
Justiça com a própria câmera: imagens vigilantes e cultura participativa nas mídias
Authors: Polydoro Felipe da Silva
Published: January 2024

Discute-se aqui o avanço do fenômeno da vigilância participativa nas mídias, tendo como objeto de análise produtos do jornalismo policial. Parte-se da hipótese de que, nas quatro décadas aqui englobadas, a ênfase na relação com a audiência passou da disciplinarização repressiva para a criação de agentes privados de justiça. O desenvolvimento da argumentação enfoca quatro produtos de diferentes períodos: o programa radiofônico de Gil Gomes (1977-1988), o televisivo Linha Direta (1999-2007) e os telejornais Cidade Alerta e Brasil Urgente (2020-2023). Nos casos mais recentes, há a incorporação de variadas imagens vigilantes na construção de um olhar policial homogêneo, que simultaneamente transfere funções securitárias ao espectador privado e intensifica o imaginário do medo que sustenta a necropolítica de segurança. Nota-se ainda o transbordamento crescente no papel e no lugar social de três instâncias – as mídias, a audiência e as instituições de justiça.
Os referenciais geoculturais na crítica jornalística de cinema: um estudo de caso a partir de Bacurau
Authors: Rocha Vinícius Oliveira , Aguiar Sonia
Published: January 2024

Este artigo busca demonstrar como os referenciais geoculturais e contextos político-ideológicos em que se inserem os críticos de cinema influenciam os argumentos que utilizam em suas análises. Essa abordagem toma como base um estudo de caso do filme brasileiro Bacurau, codirigido por Kleber Mendonça Filho e Juliano Dornelles, e toma como procedimento metodológico a Análise Temática. Para isso, elegeu-se como corpus um conjunto de 52 críticas jornalísticas do filme escritas em português, inglês e francês, veiculadas em diferentes plataformas. Recorte de uma pesquisa mais ampla, os resultados da análise evidenciam como os críticos buscam legitimar suas posições de saber diante da obra fílmica, a partir de construções discursivas amparadas em certas estratégias recorrentes de referências subjetivas, contextuais e cinematográficas.
Espaços de coexistência, identidade de pessoas pretas e representações visuais
Authors: Drigo Maria Ogécia , Souza Luciana Coutinho Pagliarini de , Pimenta Maria Alzira de Almeida
Published: January 2024

Visando contribuir para a compreensão do potencial de representações visuais para gerar espaços de convivência com o outro e mostrar facetas do processo de construção da identidade de pessoas pretas, apresentamos resultados de pesquisa que trata da alteridade em relação a representações visuais em livros didáticos do ensino fundamental. Apresentamos definições e classificações de signos na perspectiva da semiótica peirceana; assim como reflexões sobre a razão negra, na perspectiva de Mbembe, e análises de representações visuais extraídas de livros de Geografia inseridos na amostra da pesquisa. Valendo-nos da semiótica peirceana buscamos identificar em tais representações visuais o posicionamento em relação ao outro e a gradação entre xenofobia e xenofilia, bem como verificar se elas se reportam a facetas do processo de construção da identidade de pessoas pretas, tal como propõe Mbembe.
Estudar o que se vive, estudar o que não se vive: a subjetividade de sujeitos-pesquisadores nos estudos sobre estigma
Authors: Martino Luis Mauro Sá , Marques Ângela Cristina Salgueiro
Published: January 2024

Em nossas atividades de orientação de pesquisa, com frequência somos interpelados por estudantes interessados em estudar processos de estigmatização derivados de suas próprias vivências. A presença de sujeitos vinculados a grupos historicamente estigmatizados em cursos de graduação e pós-graduação coloca, para docentes e discentes, o desafio de repensar as práticas de pesquisa coloca, para docentes e discentes, o desafio de repensar as práticas de pesquisa: como articular o respeito às vivências dos sujeitos pesquisadores atravessados por experiências de estigmatização com os rigores e prazos acadêmicos? Este texto nasce das atividades de orientação, na observação assistemática, mas constante, dos desafios trazidos no encontro de subjetividades desse espaço acadêmico. Trabalha-se em três eixos: (1) aspectos do conceito de estigma; (2) suas implicações na constituição de sujeitos pesquisadores; e (3) os deslocamentos teóricos decorrentes desse processo. O pano de fundo é a experiência do ensino de Comunicação.
Media education and the limits of “literacy”: Ecological orientations to performative platforms
Authors: Nichols T. Philip , LeBlanc Robert Jean
Published: January 2024

Recently, talk of “fake news” – and its relation to wider epistemic crises, from climate denialism to the creep of global ethnonationalism – has renewed attention to media literacy in education. For some, revived discussions of media literacy offer protection (e.g., strategies for identifying and critiquing media bias and misinformation). For others, they offer empowerment (e.g. equipping youth to produce media messages that challenge misinformation or represent marginalized perspectives). In this article, we consider how such approaches, while often generative, retain a focus of media pedagogy that centers the actions of individual humans – namely, “literacies”, or practices associated with the interpretation or creation of media texts.
A indústria fonográfica digital: transformações e tendências da nova economia da música sob a lógica de plataformização
Authors: Zincone Rafael
Published: January 2024

Esta resenha é sobre o livro A indústria fonográfica digital: formação, lógica e tendências de Leonardo De Marchi. A obra apresenta uma análise densa da reestruturação e diversas transformações da indústria fonográfica a partir da década de 2010. A principal preocupação do autor é entender como se formou e como opera a indústria fonográfica digital como um todo. Tal esforço se manifesta também na intenção de observar possíveis desdobramentos (tendências) dessa nova lógica de produção, distribuição e consumo de música gravada. Nessa síntese referente à pesquisa de vários anos, o autor destaca um alinhamento do modus operandi da economia da música plataformizada à lógica do mercado financeiro – o que apresenta desafios não só teóricos, mas políticos diante de novos desafios da produção cultural e musical.
O uso social das mídias pelo campo da educação: uma análise do processo de reformulação da plataforma YouTube Edu (2022-2023)
Authors: Escudero Camila , Palanch Wagner , Vieira Aline
Published: January 2024

Este artigo relata aspectos metodológicos do processo de reestruturação da plataforma YouTube Edu, a partir da análise de mais de mil novos vídeos, em uma interface entre educação e comunicação. Busca-se compreender: (1) formas de produção de conteúdo; (2) características dos sujeitos produtores; e (3) circulação e oferta de conteúdo educativo em ambiente digital. De abordagem qualiquantitativa, a técnica de pesquisa utilizada foi a pesquisa-ação. Os resultados mostram que não há um modelo único de produção de conteúdo educativo para plataformas digitais no Brasil, e seus usos seguem critérios de circulação, princípios colaborativos e formatação estabelecidos pela plataforma. Foram evidenciados progressos relacionados a aspectos de diversidade, gênero e inclusão e formação acadêmica do professor, e necessidades de avanço em questões de exclusão social e protagonismo do estudante.
Do museu à reportagem à sala de aula: a transposição didática de reportagens baseadas em fontes museológicas
Authors: Profeta Guilherme Augusto Caruso
Published: January 2024

Este artigo intencionou registrar, por meio de observação docente, a utilização de reportagens jornalísticas baseadas na interlocução com museus (históricos/arqueológicos e/ou de história natural) como prática educativa em sala de aula, de modo a contribuir para a compreensão deste processo de múltiplas transposições didáticas. Para atingir tal fim, discutiu-se a função social/educacional dos museus e do jornalismo em articulação com a educação escolar. Duas sessões de observação foram conduzidas: uma durante uma aula de História do Brasil cujo tema foi decolonização, e outra durante uma aula de Biologia cujo tema foi a ação humana na perda da biodiversidade. Como resultado, destaca-se que a utilização das reportagens permitiu aos docentes extrapolar os respectivos currículos, incluindo discussões sobre tópicos socialmente agudos do presente.
“Isso te incomoda?”: relações possíveis entre educação sexual e ficção televisiva seriada com base na série Feras
Authors: Hergesel João Paulo , Mattos Geórgia de
Published: January 2024

Educação sexual é um tema polêmico no cotidiano escolar brasileiro; entretanto, nota-se na produção audiovisual contemporânea o surgimento de narrativas que fomentam o olhar crítico do espectador sobre assuntos relacionados a gênero e sexualidade. Esse artigo tem como objetivo entender o modo como a ficção televisiva seriada pode motivar discussões em torno da educação sexual no cenário contemporâneo brasileiro, tendo como objeto de estudo a série Feras (2019), com enfoque no empoderamento feminino, e adotando a metodologia qualitativa e prioritariamente bibliográfica. Os principais resultados apontaram que a representação na série não reforça os padrões e normas de gênero, mas valoriza as diferenças identitárias, enquanto identidades assertivas, que preconizam uma possível transformação sociocultural.
Confronting Loneliness with Devotion
Authors: Metzger Gaudenz Urs
Published: January 2024

Today, the practice of religion is strongly influenced by digitalisation, in not only everyday life but also liminal situations such as dying. Apps, social networks, and virtual church services offer believers opportunities for participation when their mobility is impaired due to ageing and severe illness. This short-term ethnography explores Bible (e-)reading and (religious) encounters in a palliative care unit of a Swiss hospital, drawing on in-depth interviews, participant observation, and documentary photography. Using the case of a devout Protestant, who was chosen as a case study from a sample of 12 terminally ill patients, I will investigate 1) the existential issues involved in the dying process, 2) how Bible (e-)reading alleviates these issues, and 3) the networks and encounters with which the practice is connected. The results show that anticipation of death in conjunction with personality and social issues bestow a complex emotional tone on the Christian’s end-of-life journey. Bible reading, performed both through mobile mediation and face-to-face with companions, is an avenue through which to gain strength and hope in this difficult situation. Another important finding is that the devotional practice involves an exchange of gifts, which transposes the practice into a moral economy of compassion and care.
Islam during the Time of Pandemics: Islamic Arab Scholars’ Framing of covid-19
Authors: Galal Ehab
Published: January 2024

In the Arab countries, restrictions on events and gatherings due to covid-19 have as elsewhere affected religious practices. Mosques and churches have been closed temporarily and religious authorities have taken part in public discussions about the meaning and way of dealing with covid-19. In this context, the article explores the interaction between state and religion by analysing the arguments used by Muslim authorities to legitimize or challenge the Arab states’ politics towards covid-19 in the spring 2020. The scientific and secular arguments of the states are met by three positionings among Muslim authorities: Those who based on religious dogma agree with and confirm the states’ approach to covid-19; those who argue that religion gives all the answers; and those who discard and distrust the states’ motives and dealings. Accordingly, handling the covid-19 in the Arab countries repeats frequent positions in the continuing discussion on religion in Arab societies.
“You Can’t Fight What’s Already Happening, Right?”: A Case Study of Christian Live-Streaming
Authors: Anderson LaRisa Denise
Published: January 2024

Since the onset of covid-19, live-stream has become a popular addition to contemporary church technologies. This case study includes interviews with six church leaders representing two churches of varying sizes, demographics, and resources in Austin, Texas, in 2019. This study applies Heidi Campbell (2010)’s Religious-Social Shaping of Technology (rsst) framework to the operationalization of community on live-stream compared to physical gatherings. Interview data and observational field notes were thematically analyzed following the four tenets of rsst. Findings show both churches use live-stream to serve three self-identified audiences: (1) members with accessibility needs, (2) the unchurched who need an introduction to Christianity, and (3) an imagined community of “burned” ex-churchgoers who still desire connection. Live-stream was unilaterally deployed to (1) meet people where they are, (2) promote healthy discourse, and (3) expand the church. Implications for deploying technology in churches without critically examining affordances, disconnection, and organizational mission are discussed.
Reinterpretation of Social Media as Resource for Ministry and Missionary Work
Authors: Grishaeva Ekaterina I. , Shumkova Valeria A.
Published: January 2024

Previous studies have primarily analysed religious media practitioners (rmp s) as authoritative figures who either challenge or project online traditional religious authorities. However, the routinised internet becomes more of a resource used by rmp s to communicate religious message. Given this, our study focuses on rmp s agency manifestation when they mobilize the internet as a resource. We conceptualize agency as related to structure (Sewell, 1992) and unfolding across time (Emirbayer and Mische, 1998). Our analysis is based on two cases from the Russian Orthodox Church. We argue that religious socialization (internalized schemas and access to resources) empowers rmp s agency and shapes the format of media project (traditionalist ministry or modernist missionary work). It affects the way rmp s ‘manoeuvre’ between Orthodox and media schemas while working on social media – they either reproduce the bounded community space or stimulate open discussions. In both cases rmp s’ knowledge endows them with certain power over hierarchy.
Fit and Viable Determinants of Gamification in Christian Religious Studies in Developing Economy Context
Authors: Akuetteh Alfred Patterson , Kolog Emmanuel Awuni , Boateng Richard , Egala Sulemana Bankuoru
Published: January 2024

Gamification has been utilized in bible applications for religious learning activities to create excitement and encourage positive behavioral outcomes. However, there is a noticeable gap in the effectiveness and viability of gamified bible applications, particularly among Ghanaian Christian faiths. In this study, we explored the fit and viability of gamification in Christian religious studies. Based on the Fit-Viability Theory, we analyzed data from 432 respondents from various Christian denominations in Ghana using structural equation modelling. Our findings revealed that Task and Technology Characteristics, Economic, Organizational, and individual Christian Doctrines significantly influence the adoption and use of gamified Bible applications in a developing country context.
Multicultural and Intercultural Education in Hong Kong: Insights from a Minority-Majority Secondary School
Authors: Ma Peicong , Bhowmik Miron , Lin Jason Cong , Jackson Liz
Published: January 2024

This case study explored how the principles of multicultural and intercultural education are reflected in a minority-majority Hong Kong secondary school (that is, a school where most students are ethnic minorities). The findings suggest that the school illustrates several aspects of multicultural and intercultural education, especially content integration, prejudice reduction, equity pedagogy, and democratic deliberation, particularly in relation to school-based material, teacher sensitivity, and dialogical reasoning. The main hurdles discovered are language learning difficulties and an unsupportive social environment. This study contributes to literature on the development of multicultural and intercultural education in Hong Kong and offers directions for generalizable future research.
Eugenia lavradensis (Myrtaceae), a new species from the Brazilian Amazon
Authors: TULER AMÉLIA CARLOS , SOBRAL MARCOS , AMORIM GABRIELA
Published: January 2024

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Long-run and Short-run Dynamic Linkages Among Capacity Utilization, Inflation and Per Capita Income: Theoretical and Empirical Enquiries for Panel of Countries
Authors: Chatterjee Tonmoy , Bhattacharjee Kinkini , Das Ramesh Chandra
Published: January 2024

Traditional macroeconomic theory explains inflation as the result of excess demand surpassing the full employment level of supply. However, achieving full employment doesn’t necessarily mean that the production system is operating at its maximum capacity. When production falls short of its potential, this underutilization is commonly observed in imperfect markets, and it can be one of the factors contributing to inflation. Additionally, excess capacity can have adverse effects on the overall economic system, potentially leading to lower income generation. In light of these considerations, this study develops a theoretical model that incorporates capacity utilization, inflation and per capita GDP (PCGDP) as the key indicators. It empirically investigates whether there are long-term associations and short-term dynamics among these variables in a panel of 28 countries (14 from developed and 14 from developing regions) over the period 2003–2019. The findings reveal that there are clear long-term relationships among the variables. In the short term, capacity utilization and PCGDP are found to influence inflation in the developed countries, but this relationship is not observed in developing countries. Conversely, PCGDP is influenced by capacity utilization and inflation rates in developing economies. Interestingly, there are no causal relationships observed in the panel of all the countries.
Hidden Coronary Artery Ostium and Sudden Death
Authors: Tan Luzern , Heath Karen , Byard Roger W.
Published: January 2024

A 1-week-old girl died suddenly and unexpectedly. At autopsy the major finding was of a right dominant coronary artery circulation with an inapparent left coronary artery ostium. After careful examination, an anomalous origin of the left coronary artery was found with the ostium located in the non-coronary cusp immediately adjacent to the commissure of the non- and left coronary cusps. The ostium was of small caliber with an obliquely oriented artery (<45°) with no ostial ridges. The artery coursed anteriorly past the left coronary cusp between the aorta and the left atrial appendage to then follow its usual course inferiorly along the anterior aspect of the left ventricle. The reminder of the autopsy was unremarkable. Death was, therefore, attributed to an anomalous and hypoplastic left coronary artery (and ostium) with an acute angle of take-off. Tracing coronary arteries in the very young may be technically difficult due to their small size, thus identifying the location of ostia is important. This may be difficult when the ostium was located close to a commissure.
First Reported Histologically and Molecularly Confirmed Bilateral High-Grade Serous Ovarian Adenocarcinoma Metastasized to Placental Decidua of the Membranes
Authors: El Emrani Salma , Nooij Linda S. , Lap Chiara C. M. M. , van der Meeren Lotte E.
Published: January 2024

A 43-year-old female presented with blood loss and persistent abdominal pain at 14 weeks of gestation. Ultrasound examination and subsequent magnetic resonance imaging (MRI) revealed bilateral multicystic uterine adnexa. Exploratory laparotomy was performed at 17 weeks of gestation and bilateral serous ovarian adenocarcinoma FIGO stage IIIC was diagnosed. Complete cytoreductive surgery (CRS) was not feasible at that moment. Nine days after the exploratory laparotomy, immature rupture of membranes and contractions occurred and she delivered a premature boy after 19 weeks of gestation. Pathological examination of the placenta revealed that her ovarian cancer metastasized to the membranes. We describe the first case of ovarian cancer metastasized to the decidua of the placental membranes with histological, immunohistochemical, and molecular confirmation. This case highlights the importance of conscientious evaluation of placenta and membranes in pregnant women with ovarian cancer.
Periapical Pathologies Treated with Conservative Approach
Authors: Khan Mohammad Imran , Arif Khushboo , Khare Abhisheik , Mishra Pradyumna
Published: January 2024

Periapical pathologies are encountered routinely on an endodontically compromised tooth which may or may not be painful. The lesions resulting from few millimeters to centimeters can be a cyst, granuloma or an abscess combinedly comprising up to more than 90% of all periapical lesions. Various methods can be used for the treatment of the periapical lesions using modern endodontic techniques including endodontic microscopes, ultrasonic irrigation tips, intra canal calcium hydroxide medicaments, advanced cleaning and shaping endodontic files and advanced obturation techniques. The goal of the endodontic treatment is to provide a complete aseptic environment with complete sealing of root canal and coronal restoration with absolute eradication of any microbial growth for successful resolution of the lesions. We are reporting here multiple cases where we used calcium hydroxide as an intra-canal medicament for its antibacterial properties and intra-canal medicament for the treatment of periapical lesions.
Bizarre Electrocardiogram in an Elderly Man
Authors: Mondal Sudipta , Raja Dinesh P , Vijay Jyothi
Published: January 2024

We present a bizarre electrocardiogram that needs critical evaluation to avoid unnecessary investigations.
Experimental and density functional theory studies on some metal oxides and the derived nanoclusters: a comparative effects on human ferritin
Authors: Al-Garawi Zahraa S. , Ismail Ahmad H. , Hillo Duaa H. , Öztürkkan Füreya Elif , Necefoğlu Hacali , Mohamed Gehad G. , Abdallah Abanoub Mosaad
Published: January 2024

A comprehensive investigation into the green synthesis of metal oxide nanoparticles (NPs) has garnered significant attention due to its commendable reliability, sustainability, and environmentally friendly attributes. Green synthesis methods play a crucial role in mitigating the adverse effects associated with conventional approaches employed for nanostructure preparation. This research endeavors to examine the impact of ginger plant extract-assisted green synthesis of metal oxides NPs on the serum ferritin levels of anemic diabetic patients in vitro, focusing specifically on α-Fe2O3 and ZnO NPs. Sixty diabetic volunteers with anemia (35–50 years) and thirty healthy volunteers were enrolled as controls. The assessment was conducted using the VIDAS Ferritin (FER) assay. Photoluminescence (PL) spectroscopy measurements were performed to elucidate the intrinsic and extrinsic transitions of these NPs, affirming the successful formation of α-structured iron oxide. Density functional theory (DFT) calculations were carried out at the B3LYP/6-311++G(d,2p) level of theory to investigate the geometry optimization and molecular electrostatic potential maps of the NPs. Furthermore, TD-DFT calculations were employed to explore their frontier molecular orbitals and various quantum chemical parameters. The binding affinity and interaction types of ZnO and α-Fe2O3 NPs to the active site of the human H-Chain Ferritin (PDB ID: 2FHA) target were determined with the help of molecular docking. Results unveiled the crystalline structure of ZnO and the α-structure of α-Fe2O3. Analysis of the frontier molecular orbitals and dipole moment values demonstrated that ZnO (total dipole moment (D) = 5.80 µ) exhibited superior chemical reactivity, biological activity, and stronger molecular interactions with diverse force fields compared to α-Fe2O3 (D = 2.65 µ). Molecular docking of the metal oxides NPs with human H-chain ferritin provided evidence of robust hydrogen bond interactions and metal-acceptor bonds between the metal oxides and the target protein. This finding could have a great impact on using metal oxides NPs-ferritin as a therapeutic protein, however, further studies on their toxicity are required.

Graphical abstract
Cellograph: a semi-supervised approach to analyzing multi-condition single-cell RNA-sequencing data using graph neural networks
Authors: Shahir Jamshaid A. , Stanley Natalie , Purvis Jeremy E.
Published: January 2024

With the growing number of single-cell datasets collected under more complex experimental conditions, there is an opportunity to leverage single-cell variability to reveal deeper insights into how cells respond to perturbations. Many existing approaches rely on discretizing the data into clusters for differential gene expression (DGE), effectively ironing out any information unveiled by the single-cell variability across cell-types. In addition, DGE often assumes a statistical distribution that, if erroneous, can lead to false positive differentially expressed genes. Here, we present Cellograph: a semi-supervised framework that uses graph neural networks to quantify the effects of perturbations at single-cell granularity. Cellograph not only measures how prototypical cells are of each condition but also learns a latent space that is amenable to interpretable data visualization and clustering. The learned gene weight matrix from training reveals pertinent genes driving the differences between conditions. We demonstrate the utility of our approach on publicly-available datasets including cancer drug therapy, stem cell reprogramming, and organoid differentiation. Cellograph outperforms existing methods for quantifying the effects of experimental perturbations and offers a novel framework to analyze single-cell data using deep learning.
Comparative physiological and transcriptome analysis between potassium-deficiency tolerant and sensitive sweetpotato genotypes in response to potassium-deficiency stress
Authors: Jin Rong , Yan Mengxiao , Li Guanghua , Liu Ming , Zhao Peng , Zhang Zhe , Zhang Qiangqiang , Zhu Xiaoya , Wang Jing , Yu Yongchao , Zhang Aijun , Yang Jun , Tang Zhonghou
Published: January 2024

Background

Sweetpotato is a typical ‘‘potassium (K+) favoring’’ food crop, which root differentiation process needs a large supply of potassium fertilizer and determine the final root yield. To further understand the regulatory network of the response to low potassium stress, here we analyze physiological and biochemical characteristics, and investigated root transcriptional changes in two sweetpotato genotypes, namely, - K tolerant “Xu32” and - K susceptible“NZ1”.

Result

We found Xu32 had the higher capability of K+ absorption than NZ1 with better growth performance, higher net photosynthetic rate and higher chlorophyll contents under low potassium stress, and identified 889 differentially expressed genes (DEGs) in Xu32, 634 DEGs in NZ1, 256 common DEGs in both Xu32 and NZ1. The Gene Ontology (GO) term in molecular function enrichment analysis revealed that the DEGs under low K+ stress are predominately involved in catalytic activity, binding, transporter activity and antioxidant activity. Moreover, the more numbers of identified DEGs in Xu32 than that in NZ1 responded to K+-deficiency belong to the process of photosynthesis, carbohydrate metabolism, ion transport, hormone signaling, stress-related and antioxidant system may result in different ability to K+-deficiency tolerance. The unique genes in Xu32 may make a great contribution to enhance low K+ tolerance, and provide useful information for the molecular regulation mechanism of K+-deficiency tolerance in sweetpotato.

Conclusions

The common and distinct expression pattern between the two sweetpotato genotypes illuminate a complex mechanism response to low potassium exist in sweetpotato. The study provides some candidate genes, which can be used in sweetpotato breeding program for improving low potassium stress tolerance.