bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of traditional and complementary medicine for COVID 19 prophylaxis among healthcare professionals and students in Jordan: A cross-sectional study
Authors: Bulatova Nailya , Younes Sara , Arabiyat Majd , Abukaff Ahmad , Madanat Sara , Alqudah Eman , Hamati Anoud , Halawa Farah , Younes Abdallah
Published: October 2022

Introduction

There is inadequate evidence to recommend the use of any traditional and complementary medicine (T&CM) methods such as vitamin, mineral, herbal or other dietary supplements to prevent or treat COVID 19. Members of the medical team are particularly at risk of exposure to high viral load of coronavirus. They have also the best access to professional information regarding disease treatment and prophylaxis and disseminate such knowledge.

The aim of the study was to assess the prevalence of use of T&CM for the prophylaxis of COVID 19 among the healthcare professionals and students in Jordan, along with the most common types and the factors associated with T&CM use.

Methodology

A cross-sectional study of T&CM use was conducted in Jordan using a snowball sampling method to distribute Google Forms and to enrol participants during coronavirus outbreak between June 10, 2021, and August 28, 2021. The study included healthcare professionals or students who consented to participate in the survey. The survey excluded those participants who had filled the questionnaire at least once or were pregnant/breast-feeding at the time of the study. The questionnaire consisted of 29 items, including screening, checkbox, dichotomous, matrix and open-ended questions.

Results

The response rate was 97.1%. Out of 560 study respondents, 359 (64.1%) reported using T&CM for COVID 19 prevention. Vitamins and nutrients were consumed by almost half (48.4%) of study participants, while nonpharmacological methods and herbal remedies were consumed by 35.2% and 25.2%, respectively. The most common source of information regarding T&CM use for COVID 19 prophylaxis included scientific publications (59.5%), followed by disease treatment guidelines (38.0%) and social media (32.3%). Adverse effects were reported by 8.5% and possible adverse effects were reported by another 8.5% of participants. The T&CM use was associated with working in contact with COVID 19 patients (OR: 1.625 (95% CI 1.047–2.523) (P = 0.03) and having a colleague as a source of information (OR: 1.720 (95% CI 1.026–2.883) (P = 0.04).

Conclusions

The prevalence of T&CM use for COVID 19 prevention among healthcare professionals and students in Jordan is high, with a significant proportion of participants reporting adverse effects. There is an urgent need for further research toward efficacy and safety of T&CM in COVID 19 prophylaxis as well as development of appropriate public health policy on this issue specific to each country.
Functional representation of the network organisation of dialysis activities in France: A novel level for assessing quality of care
Authors: Couchoud Cécile , Ecochard René , Prezelin-Reydit Mathilde , Lobbedez Thierry , Bayer Florian ,   in the name of the REIN registry
Published: October 2022

To assess quality of care, groups of care units that cared for the same patients at various stages of end-stage renal disease, might be more appropriate than the centre level. These groups constitute “communities” that need to be delineated to evaluate their practices and outcomes. In this article, we describe the use of an agglomerative (Fast Greedy) and a divisive (Edge Betweenness) method to describe dialysis activities in France. The validation was based on the opinion of the field actors at the regional level of the REIN registry. At the end of 2018, ESRD care in France took place in 1,166 dialysis units. During 2016–2018, 32 965 transfers occurred between dialysis units. With the Edge Betweenness method, the 1,114 French dialysis units in metropolitan France were classified into 156 networks and with the Fast Greedy algorithm, 167 networks. Among the 32 965 transfers, 23 168 (70%) were defined in the same cluster by the Edge Betweenness algorithm and 26 016 (79%) in the same cluster by the Fast Greedy method. According to the Fast Greedy method, during the study period, 95% of patients received treatment in only one network. According to the opinion of the actors in the field, the Fast Greedy algorithm seemed to be the best method in the context of dialysis activity modelling. The Edge Betweenness classification was not retained because it seemed too sensitive to the volume of links between dialysis units.
Pupillary fluctuation amplitude preceding target presentation is linked to the variable foreperiod effect on reaction time in Psychomotor Vigilance Tasks
Authors: Yamashita Jumpei , Terashima Hiroki , Yoneya Makoto , Maruya Kazushi , Oishi Haruo , Kumada Takatsune
Published: October 2022

Understanding temporally attention fluctuations can benefit scientific knowledge and real-life applications. Temporal attention studies have typically used the reaction time (RT), which can be measured only after a target presentation, as an index of attention level. We have proposed the Micro-Pupillary Unrest Index (M-PUI) based on pupillary fluctuation amplitude to estimate RT before the target presentation. However, the kind of temporal attention effects that the M-PUI reflects remains unclear. We examined if the M-PUI shows two types of temporal attention effects initially reported for RTs in the variable foreperiod tasks: the variable foreperiod effect (FP effect) and the sequential effect (SE effect). The FP effect refers to a decrease in the RT due to an increase in the foreperiod of the current trial, whereas the SE effect refers to an increase in the RT in the early part of the foreperiod of the current trial due to an increase in the foreperiod of the previous trial. We used a simple reaction task with the medium-term variable foreperiods (Psychomotor Vigilance Task) and found that the M-PUI primarily reflects the FP effect. Inter-individual analyses showed that the FP effect on the M-PUI, unlike other eye movement indices, is correlated with the FP effect on RT. These results suggest that the M-PUI is a potentially powerful tool for investigating temporal attention fluctuations for a partly unpredictable target.
Effective length correction factor of disc-buckle type scaffolding by considering joint bending stiffness and geometrical size
Authors: Dong Jinfeng , Liu Haiqing , Lei Ming , Chen Zimu , Wang Liang , Guo Lixin , Gong Xiangen , Fang Zhou
Published: October 2022

Based on the theory of sway frame column, the equation of the effective length factor was derived in this paper. Combined with the characteristics of semi-rigid joints, the linear stiffness correction factor of horizontal bar was introduced, and the equation of effective length correction factor was obtained. By using MATLAB programming method, the three-dimensional relationship between the effective length correction factor and the influencing factors was obtained, and the entire process of the stability bearing capacity of the disc-buckle type high support system was described in detail, which improves the stability calculation theory of the high support system. The influence of setting parameters, joint bending stiffness, geometrical size, and material properties on the effective length correction factor is studied. Simultaneously, the joint bending stiffness of semi-rigid joints is determined. The area of the effective length correction factor is analyzed to optimize the design of the setting scheme using horizontal bars and vertical poles of different sizes. The results show that the lift height significantly affects the effective length correction factor during the load bearing process; the factor decreases with increasing lift height. Large transverse and longitudinal distances influence this rule during the initial load bearing. When the joint bending stiffness is less than 100 (kN·m)/rad, the effective length correction factor decreases rapidly with an increase in joint bending stiffness. When the joint bending stiffness is greater than 100 (kN·m)/rad, the effective length correction factor is unaffected by the joint bending stiffness. When the joint bending stiffness is large at initiation of loading, the effective length correction factor decreases with an increase in the outer diameter of the horizontal bar. When the joint bending stiffness is small, the effective length correction factor increases with an increase in the section size of the vertical pole. Therefore, the outer diameter of the horizontal bar significantly affects the effective length correction factor, and a larger diameter is more conducive to the overall stability. Furthermore, the elastic modulus effects the effective length correction factor for the unstable support system.
Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis
Authors: Berke Gergő , Gede Noémi , Szadai Letícia , Ocskay Klementina , Hegyi Péter , Sahin-Tóth Miklós , Hegyi Eszter
Published: October 2022

Introduction

Cystic fibrosis transmembrane conductance regulator (CFTR) plays a central role in pancreatic ductal fluid secretion by mediating Cl- and HCO3- ion transport across the apical membrane. Severe CFTR mutations that diminish chloride conductance cause cystic fibrosis (CF) if both alleles are affected, whereas heterozygous carrier status increases risk for chronic pancreatitis (CP). It has been proposed that a subset of CFTR variants characterized by a selective bicarbonate conductance defect (CFTRBD) may be associated with CP but not CF. However, a rigorous genetic analysis of the presumed association has been lacking.

Aims

To investigate the role of heterozygous CFTRBD variants in CP by meta-analysis of published case-control studies.

Materials and methods

A systematic search was conducted in the MEDLINE, Embase, Scopus, and CENTRAL databases for published studies that reported the CFTRBD variants p.R74Q, p.R75Q, p.R117H, p.R170H, p.L967S, p.L997F, p.D1152H, p.S1235R, and p.D1270N in CP patients and controls.

Results

Twenty-two studies were eligible for quantitative synthesis. Combined analysis of the 9 CFTRBD variants indicated enrichment in CP patients versus controls (OR = 2.31, 95% CI = 1.17–4.56). Individual analysis of CFTRBD variants revealed no association of p.R75Q with CP (OR = 1.12, 95% CI = 0.89–1.40), whereas variants p.R117H and p.L967S were significantly overrepresented in cases relative to controls (OR = 3.16, 95% CI = 1.94–5.14, and OR = 3.88, 95% CI = 1.32–11.47, respectively). The remaining 6 low-frequency variants gave inconclusive results when analyzed individually, however, their pooled analysis indicated association with CP (OR = 2.08, 95% CI = 1.38–3.13).

Conclusion

Heterozygous CFTRBD variants, with the exception of p.R75Q, increase CP risk about 2-4-fold.
Comparison of the predictive ability for perinatal acidemia in neonates between the NICHD 3-tier FHR system combined with clinical risk factors and the fetal reserve index
Authors: Pruksanusak Ninlapa , Chainarong Natthicha , Boripan Siriwan , Geater Alan
Published: October 2022

Background

Electronic fetal monitoring alone is a poor screening test for detecting fetuses at risk of acidemia or asphyxia. We aimed to evaluation of predictive ability of the National Institute of Child Health and Human Development (NICHD) 3-tier fetal heart rate (FHR) system combined with the maternal, obstetric, and fetal risk factors for predicting perinatal acidemia, and to compare this with the predictive of the NICHD 3-tier system alone, and the Fetal Reserve Index (FRI).

Methods

A retrospective cohort study was conducted among singleton term pregnant women. Fetal heart rate tracings of the last two hours before delivery were interpreted into the NICHD 3-tier FHR classification system by two experienced obstetricians. Demographic data were compared using the χ2 or Fisher’s exact test for categorical variables and the Student’s t test for continuous variables. Logistic regression model was used to identify factors associated with perinatal acidemia in neonates. The Odds ratios (OR) and probabilities with 95% confidence intervals (CI) were calculated.

Results

A total of 674 pregnant women were enrolled in this study. Using the NICHD 3-tier FHR categories I and II combined with the selected risk factors (AUC 0.62) had a better performance for perinatal acidemia prediction than the NICHD 3-tier FHR alone (AUC 0.55) and the FRI (AUC 0.52), (P<0.01). Improvement of predicting perinatal acidemia was found when NICHD category I was combined with preeclampsia or arrest disorders of labor (OR 3.2, 95% CI 1.30‒7.82) or combined with abnormal second stage of labor (OR 6.19, 95% CI 1.07‒36.06) and when NICHD category II was combined with meconium-stained amniotic fluid (OR 4.73, 95% CI 2.17‒10.31).

Conclusions

The NICHD 3-tier FHR categories I or II combined with selected risk factors can improve the predictive ability of perinatal acidemia in neonates compared with the NICHD 3-tier system alone or the FRI.
Stakeholder engagement in a hypertension and diabetes prevention research program: Description and lessons learned
Authors: Shrestha Archana , Tamrakar Dipesh , Shrestha Bhawana , Karmacharya Biraj Man , Shrestha Abha , Pyakurel Prajjwal , Spiegelman Donna
Published: October 2022

Background

Stakeholder engagement is important from the management point of view to capture knowledge, increase ownership, reduce conflict, encourage partnership, as well as to develop an ethical perspective that facilitates inclusive decision making and promotes equity. However, there is dearth of literature in the process of stakeholder engagement. The purpose of this paper is to describe the process of increasing stakeholder engagement and highlight the lessons learnt on stakeholder engagement while designing, implementing, and monitoring a study on diabetes and hypertension prevention in workplace settings in Nepal.

Methodology

We identified the stakeholders based on the 7P framework: Patients and public (clients), providers, payers, policy makers, product makers, principal investigators, and purchasers. The identified stakeholders were engaged in prioritization of the research questions, planning data collection, designing, implementing, and monitoring the intervention. Stakeholders were engaged through focus group discussions, in-depth interviews, participatory workshops, individual consultation, information sessions and representation in study team and implementation committees.

Results

The views of the stakeholders were synthesized in each step of the research process, from designing to interpreting the results. Stakeholder engagement helped to shape the methods and plan, and process for participant’s recruitment and data collection. In addition, it enhanced adherence to intervention, mutual learning, and smooth intervention adoption. The major challenges were the time-consuming nature of the process, language barriers, and the differences in health and food beliefs between researchers and stakeholders.

Conclusion

It was possible to engage and benefit from stakeholder’s engagement on the design, implementation and monitoring of a workplace-based hypertension and diabetes management research program in Nepal.
MALDI-TOF MS: An effective tool for a global surveillance of dengue vector species
Authors: Rakotonirina Antsa , Pol Morgane , Raharimalala Fara Nantenaina , Ballan Valentine , Kainiu Malia , Boyer Sébastien , Kilama Sosiasi , Marcombe Sébastien , Russet Sylvie , Barsac Emilie , Vineshwaran Rama , Selemago Malia Kaleméli , Jessop Vincent , Robic Geneviève , Girod Romain , Brey Paul T. , Colot Julien , Dupont-Rouzeyrol Myrielle , Richard Vincent , Pocquet Nicolas
Published: October 2022

Dengue, Zika and chikungunya viruses cause significant human public health burdens in the world. These arboviruses are transmitted by vector mosquito species notably Aedes aegypti and Aedes albopictus. In the Pacific region, more vector species of arboviruses belonging to the Scutellaris Group are present. Due to the expansion of human travel and international trade, the threat of their dispersal in other world regions is on the rise. Strengthening of entomological surveillance ensuring rapid detection of introduced vector species is therefore required in order to avoid their establishment and the risk of arbovirus outbreaks. This surveillance relies on accurate species identification. The aim of this study was to assess the use of the Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS) as a tool for an international identification and surveillance of these mosquito vectors of arboviruses. Field-mosquitoes belonging to 8 species (Ae. aegypti, Ae. albopictus, Aedes polynesiensis, Aedes scutellaris, Aedes pseudoscutellaris, Aedes malayensis, Aedes futunae and Culex quinquefasciatus) from 6 countries in the Pacific, Asian and Madagascar, were included in this study. Analysis provided evidence that a MALDI-TOF database created using mosquitoes from the Pacific region allowed suitable identification of mosquito species from the other regions. This technic was as efficient as the DNA sequencing method in identifying mosquito species. Indeed, with the exception of two Ae. pseudoscutellaris, an exact species identification was obtained for all individual mosquitoes. These findings highlight that the MALDI-TOF MS is a promising tool that could be used for a global comprehensive arbovirus vector surveillance.
Endoscopic ultrasound-guided tissue acquisition for splenic lesions: A systematic review and meta-analysis of diagnostic test accuracy
Authors: Pan Xiao , Huang Shu , Gan Peiling , Shi Lei , Xia Huifang , Zeng Xinyi , Zhang Han , Lü Muhan , Zhou Xian , Tang Xiaowei
Published: October 2022

Background and aims

At present, it is difficult and risky to diagnose splenic lesions by conventional needle biopsy using computed tomography (CT) or ultrasound (US). Endoscopic ultrasound (EUS)-guided tissue acquisition is increasingly being used as a new technique to determine the tissue diagnosis of splenic lesions. Therefore, our goal was to determine the efficacy and safety of EUS-guided tissue acquisition for splenic lesions.

Methods

We performed a systematic review and meta-analysis to evaluate the pooled sensitivity and specificity of EUS-guided tissue acquisition for the diagnosis of splenic lesions using Metadisc. The Quality Assessment of Diagnostic Accuracy Studies Questionnaire, a quality assessment tool, was used to scrutinize the quality of the studies.

Results

Six eligible studies between January 2000 and June 2022 were identified, and a total number of 62 patients (aged range from 19 to 84) were enrolled. One patient was excluded because of insufficient specimens. The pooled sensitivity and specificity of included studies were 0.85 [95% confidence interval (CI), 0.73–0.93] and 0.77 (95% CI, 0.46–0.95), respectively. The pooled positive likelihood ratio (LR) was 2.38 (95% CI, 1.24–4.57), the pooled negative LR was 0.31 (95% CI, 0.17–0.55), the pooled diagnostic odds ratio (DOR) was 8.67 (95% CI, 2.80–26.82), the area under the summary receiver operating characteristic (SROC) curve was 0.8100 (Standard Error 0.0813).

Conclusion

EUS-guided tissue acquisition is a safe technique with high sensitivity in the diagnosis of splenic lesions. However, because of the small sample sizes, more studies with more cases are needed to further validate these results.
Effects of different weaning times on the stress response and the intestinal microbiota composition of female forest musk deer (Moschus berezovskii) and their fawns
Authors: Li Yimeng , Shi Minghui , Zhang Baofeng , Wu Jiahui , Wang Yichen , Li Mengqi , Wu Yining , Hu Xin , Hu Defu , Huang Zhixin , Wronski Torsten
Published: October 2022

The effects of mother-infant separation (i.e., weaning) on the physiology, psychology and nutrition of mammalian infants have attracted much attention. Forest musk deer (FMD) is a first-class protected species in China and listed endangered in the IUCN Red List. The captive breeding population is not only an important source for restocking of wild resources, but also a necessary way to supply the market with legal musk. So far, there is no scientific basis for the appropriate separation time of FMD females and their infants. Therefore, we used metagenome sequencing and enzyme-linked immunosorbent assays to study changes in the fecal cortisol concentration, as well as the intestinal microbiome composition and function of females and fawns at three different separation times, i.e., after 80 days, 90 days and 100 days. The results showed that the increment of the cortisol concentration in female FMD increased with increasing lactation time. The increment of cortisol concentration in infant FMD was highest in the 80 days weaning group, but there was no significant difference between the 90 days and the 100 days separation time. Based on the annotation results of COG, KEGG and CAZy databases, the abundance of different functions annotated by the intestinal microbiome of mothers and fawns of the 90 days weaning group changed slightly after separation. Based on the above results, the separation of mother and infant FMD is recommended after 90 days, i.e., the separation time that triggered the lowest rate of weaning stress and that supported a relatively stable gastro-intestinal physiology.
Information about confirmatory studies required for new drugs conditionally approved by Health Canada: A cross-sectional study
Authors: Lexchin Joel
Published: October 2022

Background

Health Canada conditionally approves new drugs using its Notice of Compliance with conditions (NOC/c) policy. Under this policy Qualifying Notices (QNs) list confirmatory studies that need to be conducted to confirm the drug’s efficacy. This study examines the depth of information about methodology and patient demographics in the confirmatory studies. It also compares the outcomes (surrogate or clinical) used to approve the drugs with the outcomes proposed in the confirmatory studies.

Methods

A list of drugs approved under the NOC/c policy and their QNs were sourced from two previous publications as well as Health Canada’s NOC/c website. Patient demographics and study methodology in the confirmatory studies listed in the QNs was recorded and counted. The primary outcome used to approve new drugs was recorded from Health Canada’s Summary Basis of Decision website and compared to the type of outcome for studies mentioned in the QNs.

Results

Seventy-eight drugs were approved using a NOC/c from the time the first drug was approved under the program in July 1998 until May 18, 2022. QNs were missing or all information was redacted for 3 drugs, the remaining 75 QNs listed 154 studies (median of 2 studies per QN, interquartile range 1,3). The outcome, randomization and blinding could not be determined for any study in 43 (57.3%), 36 (48.0%) and 42 (56.0%) QNs, respectively. No study gave the distribution of men and women and the number of patients was given in 23 (14.9%) studies. The expected time of completion of the studies was available for 36 (23.4%) out of 154 and information to identify studies was present for 77 (50.0%), absent for 23 (14.9%) and unclear for 26 (16.9%). Surrogate outcomes were used to approve 54 (84.4%) of 64 drugs. Eight (14.8%) confirmatory studies for these 54 drugs used clinical outcomes, 15 (27.8%) used surrogate outcomes and outcomes were unknown for 31 (57.4%). Specifically for oncology drugs, 44 were approved with surrogate outcomes and one with a clinical outcome. Eight (18.2%) of the 44 oncology drugs approved with surrogate outcomes had confirmatory studies that used clinical outcomes, 14 (31.8%) used surrogate outcomes and the outcome could not be determined for 22 (50.0%). The sole oncology drug approved with a clinical outcome had a confirmatory study with a surrogate outcome.

Discussion

QNs contain little information about the methodology or patient demographics of confirmatory studies. Confirmatory studies with surrogate outcomes were used almost one-third of the time to validate efficacy in drugs initially approved using surrogate outcomes. Health Canada needs to develop a template about what information regarding confirmatory studies should be contained in a QN and rethink its use of confirmatory studies using surrogate outcomes. All the data were gathered by a single individual possibly introducing unintended biases.
Multi-site fungicides suppress banana Panama disease, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4
Authors: Cannon Stuart , Kay William , Kilaru Sreedhar , Schuster Martin , Gurr Sarah Jane , Steinberg Gero
Published: October 2022

Global banana production is currently challenged by Panama disease, caused by Fusarium oxysporum f.sp. cubense Tropical Race 4 (FocTR4). There are no effective fungicide-based strategies to control this soil-borne pathogen. This could be due to insensitivity of the pathogen to fungicides and/or soil application per se. Here, we test the effect of 12 single-site and 9 multi-site fungicides against FocTR4 and Foc Race1 (FocR1) in quantitative colony growth, and cell survival assays in purified FocTR4 macroconidia, microconidia and chlamydospores. We demonstrate that these FocTR4 morphotypes all cause Panama disease in bananas. These experiments reveal innate resistance of FocTR4 to all single-site fungicides, with neither azoles, nor succinate dehydrogenase inhibitors (SDHIs), strobilurins or benzimidazoles killing these spore forms. We show in fungicide-treated hyphae that this innate resistance occurs in a subpopulation of "persister" cells and is not genetically inherited. FocTR4 persisters respond to 3 μg ml-1 azoles or 1000 μg ml-1 strobilurins or SDHIs by strong up-regulation of genes encoding target enzymes (up to 660-fold), genes for putative efflux pumps and transporters (up to 230-fold) and xenobiotic detoxification enzymes (up to 200-fold). Comparison of gene expression in FocTR4 and Zymoseptoria tritici, grown under identical conditions, reveals that this response is only observed in FocTR4. In contrast, FocTR4 shows little innate resistance to most multi-site fungicides. However, quantitative virulence assays, in soil-grown bananas, reveals that only captan (20 μg ml-1) and all lipophilic cations (200 μg ml-1) suppress Panama disease effectively. These fungicides could help protect bananas from future yield losses by FocTR4.
The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance
Authors: Helble Jennifer D. , McCarthy Julie E. , Sawden Machlan , Starnbach Michael N. , Hu Linden T.
Published: October 2022

The Lyme disease bacterial pathogen,Borrelia burgdorferi, establishes a long-term infection inside its mammalian hosts. Despite the continued presence of the bacteria in animal models of disease, inflammation is transitory and resolves spontaneously. T cells with limited effector functions and the inability to become activated by antigen, termed exhausted T cells, are present in many long-term infections. These exhausted T cells mediate a balance between pathogen clearance and preventing tissue damage resulting from excess inflammation. Exhausted T cells express a variety of immunoinhibitory molecules, including the molecule PD-1. FollowingB.burgdorferiinfection, we found that PD-1 and its ligand PD-L1 are significantly upregulated on CD4+T cells and antigen presenting cell subsets, respectively. Using mice deficient in PD-1, we found that the PD-1/PD-L1 pathway did not impact bacterial clearance but did impact T cell expansion and accumulation in the ankle joint and popliteal lymph nodes without affecting B cell populations or antibody production, suggesting that the PD-1/PD-L1 pathway may play a role in shaping the T cell populations present in affected tissues.
Dem Rebound-Effekt auf der Spur: Einblicke in die Ergebnisse der Forschung zu Rebound-Effekten aus sozial-ökologischer Perspektive
Authors: Thorn Michaela , Schulz Thomas , Wilhelm Ralph
Published: October 2022

Die Steigerung der Energie- und Ressourceneffizienz gilt als Schlüssel für eine erfolgreiche Klimaschutzpolitik. Die Wirksamkeit von Effizienzmaßnahmen wird in vielen Bereichen allerdings durch Rebound-Effekte infrage gestellt. Forschungsprojekte einer sozial-ökologischen
Fördermaßnahme des Bundesministeriums für Bildung und Forschung (BMBF) zur umfassenden Untersuchung von Rebound-Effekten haben die bisher vorwiegend ökonomischen Forschungsansätze deutlich erweitert und zeigen neue Perspektiven auf. Sie liefern neue Erkenntnisse über
Rebound-Effekte und Maßnahmen zu ihrer Eindämmung.
Javanese Culture Maintenance throughTheTradition of Cutting Natural Dreadlock Hair of Dieng’s Children
Authors: Sundari Wiwiek
Published: October 2022

Javanese culture is one of many great cultures in the world possessing seven universal elements of culture covering the complex systems of belief, social organization, knowledge, language, art, livelihood, and living tools. The languageitself has been used for ages and taught in some countries for quite some time as it has its own orthography, grammar, politeness levels, and dictionary. To preserve the culture, Javanese people supported by the government put various efforts such us teaching the culture, practicing the culture, and documenting parts of the culture that has no longer being used. This research appliedDundees’s folklore research method and Sania’s research on culture maintenance to show how Dieng people along with Banjarnegara’s local government preservethe culture through the tradition of cutting the natural dreadlock hair of particular Dieng’schildren. The result shows that this sacred ceremonyutilize the seven universal elements of Javanese cultureItmeans that tradition can be one of the ways to preserve culture so that it does not have to be threatened, replaced, or even extinct. Keywords: Javanese culture, culture maintenance, tradition, cutting children’s dreadlock hair, Dieng.
Idiomatic Expression in The American Sitcom Series “Fresh Off The Boat” Directed By Nahnatchka Khan
Authors: Permatasari Ayunda , Ocktarani Yesika Maya , Mutmainnah Yulia
Published: October 2022

This research aims to classify the form and meaning of idiomatic expressions in the American Sitcom entitled “Fresh Off the Boat”. This research focus on seasons 5 and 6 that released on 2019 and 2020. The data of this research is in the form of utterances which contains idiomatic expressions uttered by three main characters, Eddie Huang, Louis Huang, and Jessica Huang. The researcher uses descriptive qualitative method to analyze the research finding. From those series, there are 93 idiomatic expressions based on theory proposed by Adam Makkai, they are 21 Phrasal Verb Idioms, 50 Tournure Idioms, 1 Irreversible Binomial Idiom, 18 Phrasal Compound Idioms, and 3 Incorporating Verb Idioms. From those data, the researcher compares the lexical and contextual meaning of idiomatic expressions in the utterances. Based on the research’s finding, several idiomatic expressions have the same lexical and contextual meaning. However, the contextual meaning dominated the meaning of idiomatic expressions in this series because an idiomatic expression cannot be seen lexically or based on the dictionary meaning. It should be seen based on the context of the idiomatic expression is used because sometimes, it carried figurative meaning.  Keywords: idiom; form of idiomatic expressions; meaning of idiomatic expression.
The Analysis of Social Deixis Used in the Downton Abbey and Made in Dagenham Movies Set in the Twentieth Century
Authors: Chandra Oktiva Herry
Published: October 2022

Communication plays an essential role for humans in making great conversations where some addressee forms are used by the speakers to give respect to others. The researcher discusses how 20th-century society represents the usage of the addressee form in showing honor or relationship to their interlocutors using social deixis theory by Levinson and social dimensions by Holmes. The study aims to demonstrate the social deixis types used and its reference meaning and explain how external factors influence social deixis forms in Downton Abbey and Made in Dagenham movies set in 20th century. This study focuses on the pragmatic approach conveying the use of linguistic choices by all movie characters. The research design includes the descriptive qualitative type. In collecting the data, the researcher uses non-participatory observation. This research shows that the relational and absolute social deixis type existed in the movie characters' utterances in 20th-century society. However, the Authorized Speaker type of absolute social deixis is not found in both movies. Beside that, this study discovers all components of social dimensions that could figure the social factors which influenced the characters' addressee forms: solidarity, relative status, formality, and two functional scales.Keywords: social deixis, pragmatics, movie, social dimension, social factor
Radical Act and Political Withdrawal in Han Kang’s The Vegetarian
Authors: Ningtyas Sulistya
Published: October 2022

The multi-interpreted narrative of Han Kang’s novel The Vegetarian is developed on an allegory. In this study, the allegory is seen as the meaning of freedom where the subject chooses to resist social intervention through the radical Act and political withdrawal — two main practices of action in the Žižek study. This study aims to examine the practices of action demonstrated by the protagonist that resulted from her childhood trauma. By applying Žižek’s theory of radical politics, the results of the study revealed the radical Act of being a vegetarian taken by the main character as her criticism of the violent environment. Further, the subject’s political withdrawal from living as a normal human indicates that she has gone beyond the radical Act. Even though the subject collapses in her effort to transform to become a tree, her courage to start taking this action in the first place confirms that she has value as an authentic subject.Keywords: vegetarian; trauma; Žižek study; radical Act; political withdrawal; The Vegetarian
Pengaruh Kualitas Produk, Harga, dan Promosi terhadap Keputusan Pembelian pada Provider Indihome PT Telkom Witel Semarang
Authors: Putri Thalia Salsadilla Amanda , Budiatmo Agung , Purbawati Dinalestari
Published: October 2022

The development of internet-based technology at this time has begun to develop following the progress of the times, this makes telecommunications service providers make an increase to consumers so that consumers have high purchasing decisions. Purchasing decisions are one of the keys to increasing product sales in a company. There are many factors in improving purchasing decisions, namely the quality of products offered by a company must have good quality, in addition to product quality, a company must also consider price, if rising prices will affect customer considerations to make purchasing decisions for the products or services offered. In addition to product quality and price, promotion also has a close relationship with high purchasing decisions. The results showed that the product quality category was stated to be very good. The price category is known to be affordable. Promotion category is declared good. Product quality is declared high. From the results of data analysis, it is known that product quality, price, and promotion have a positive and significant influence on the purchasing decision variables.Perkembangan teknologi berbasis internet pada saat ini sudah mulai berkembang mengikuti kemajuan jaman, hal ini menjadikan perusahaan penyedia layanan telekomunikasi melakukan sebuah peningkatan kepada konsumen agar para konsumen mempunyai keputusan pembelian yang tinggi. Keputusan pembelian merupakan salah satu kunci untuk dapat meningkatkan penjualan produk dalam suatu perusahaan. Ada banyak faktor dalam meningkatkan keputusan pembelian, yaitu kualitas produk yang ditawarkan oleh suatu perusahaan harus mempunyai kualitas yang baik, selain kualitas produk suatu perusahaan juga harus mempertimbangkan harga, jika naiknya harga akan mempengaruhi pertimbangan pelanggan untuk melakukankeputusan pembelian atas produk atau jasa yang ditawarkan. Selain kualitas produk dan harga, promosi juga memiliki hubungan yang erat dengan tingginya keputusan pembelian. Hasil penelitian menunjukkan bahwa kategori kualitas produk dinyatakan sangat baik. Kategori harga diketahui dinyatakan terjangkau. Kategori promosi dinyatakan baik. Kualitas produk dinyatakan tinggi. Dari hasil analisi data diketahui bahwa kualitas produk, harga, dan promosi memiliki pengaruh yang positif dan signifikan terhadap variabel keputusan pembelian.
Pengaruh Tingkat Pendapatan, Tingkat Pendidikan, dan Kepercayaan terhadap Pengambilan Keputusan Investor Milenial dalam Berinvestasi di Masa Pandemi Covid-19 (Studi pada Komunitas Investor Tjuanmuda)
Authors: Kristina Anna Tince , Hadi Sudharto P , Wijayanto Andi
Published: October 2022

The Covid-19 pandemic that has paralyzed many countries economic enforced new motivation for the millennial generation in managing their finances. Data obtained from the IDX shows an increase in the number of investors during the Covid-19 pandemic, which dominated by the millennial generation, amid the weakening economy in Indonesia. This study aims to provide a description of  factors influence millennial investor decision making in investing during the COVID-19 pandemic. In this study the influencing factors, namely income level, education level, and confidence. The theory used in this study is based on the theory of investor behaviour by Baker & Ricciardi. The type of this research is quantitative explanatory with purposive sampling technique. Data was collected through a questionnaire from 58 respondents who join the investor community named Tjuanmuda. Linear regression analysis using SPSS for windows version 26 is used to process the data. The results of this study indicate the influence of income level, education level, and confidence on investment decision making simultaneously, but partially education level has no effect on decision making. Pandemi Covid-19 yang melumpuhkan ekonomi banyak negara telah mendorong motivasi baru bagi generasi milenial dalam menata keuangan mereka. Data yang diperoleh BEI menunjukan peningkatan jumlah investor selama pandemi Covid-19 yang didominasi oleh generasi milenial, di tengah melemahnya perekonomian di Indonesia. Penelitian ini bertujuan untuk mengidentifikasi faktor apa saja yang mempengaruhi pengambilan keputusan investor millenial dalam berinvestasi di masa pandemi Covid-19. Dalam penelitian ini faktor yang mempengaruhi, yakni tingkat pendapatan, tingkat pendidikan, dan kepercayaan. Teori yang digunakan pada penelitian ini berlandaskan pada teori perilaku investor dari Baker & Ricciardi (2014). Tipe penelitian ini ialah kuantitatif eksplanatif dengan teknik pengambilan sampel menggunakan purposive sampling. Pengumpulan data dilakukan melalui kuesioner terhadap 58 responden yang tergabung dalam komunitas investor bernama Tjuanmuda. Analisis data yang digunakan ialah analisis regresi linier menggunakan SPSS untuk windows versi 26. Hasil dari penelitian ini menunjukan adanya pengaruh tingkat pendapatan, tingkat pendidikan, dan kepercayaan terhadap pengambilan keputusan secara simultan, namun secara parsial tingkat pendidikan tidak berpengaruh terhadap pengambilan keputusan.
Community-Based Organisation in a Transition Society: The Case of Balinese Ormas Conflict
Authors: Sudama I Nyoman , Sembiring Meliala Adrianus Eliasta
Published: October 2022

Transitions in Balinese society as a result of internal conflict are critical opportunities to discover solutions for a better future for the society. The problem is how to investigate the conflict as part of the Balinese transitional development stages. Thus, the objective of this research is to answer that problem by examining the irregular transition stages of mass organization, also known as ‘ormas’ in Bahasa Indonesia, as a Balinese Community-Based Organisation (CBO) to get a better insight into Balinese society's transformation. This research employs a mixed method covering quantitative and qualitative descriptive data analysis. The qualitative data is collected by employing explorative key informant interviews while a survey of 519 respondents in six regions including Tabanan, Gianyar, Badung, Karangasem, Buleleng, and Denpasar is the source of quantitative data. The analysis presents the early stage of Balinese ‘ormas’ development followed by major issues and contradictions of the ‘ormas’ based on Balinese community perceptions. The main finding is that there were distortions in ‘ormas’ life cycles that hid their comparative advantages to become an ideal CBO. This paper concludes that ‘ormas’ transformation is the important step toward ideal CBO as part of Balinese community development. Therefore, adopting Lewin’s change model with general practical steps as well as some policing practices can support the future development of Balinese CBOs for a better contribution to Balinese communities.
Innovation Capability Models to Improve the Competitiveness of Creative Industrial Products
Authors: Farida Naili , Pradhanawati Ari , Taufiq Mochamad
Published: October 2022

This study aims to build a model of innovation capability to increase the competitiveness of embroidery products in Jepara. The respondents in this study were 132 owners of embroidery SMEs. The sampling technique used was purposive sampling and the analysis technique employed Partial Least Square (PLS). Research results show a variety of knowledge, i.e., customer orientation has significant positive effect on innovation capability. Customer orientation and innovation capability significantly affect marketing performance, but competitive finance has no significant effect on marketing performance. In addition, the competitiveness of embroidery products is still low, so there is no impact on marketing performance. The competitive advantage of the product must be unique to the competitors’ embroidery products that have not been able to improve the competitiveness of their embroidery products.
ANALISIS FRAMING BERITA TAWURAN ANTAR PELAJAR DI HARIAN KOMPAS
Authors: Herieningsih Sri Widowati
Published: October 2022

Student brawls occur continuously in various cities, especially in the  Jakarta, the attention of many people, and did not escape the attention of the media. Framing Kompas is a mayor concern in this study.The study conducted by taking a sample 0f 37 news, between 2008 to 2012. The paradigm used is the paradigm of constructivism. The method used is the analysis of the model Entman framing.The results that the Kompas student brawls see that the problem is complexs issue, and not ordinary deliguency, but it leads to crime, a form of deviance. Student brawls, agroup behavior, and other problems caused by unclear, revenge hereditary, in solidarity with friends, as well as maintain the good name of the school, violence derived from the senior students to yunior. Recommendation are offfered to prevent and fight is, sanction, both preventive and repressive, conducted formal and nonformal.
KEPERCAYAAN KONSUMEN TERHADAP NIAT BELI PRODUK FASHION YANG DIPASARKAN MELALUI MEDIA SOSIAL FACEBOOK ( STUDI PADA MAHASISWA S1 FISIP UNDIP SEMARANG )
Authors: Listyorini Sari
Published: October 2022

Businesses increasingly globalized trade with the technology in the application of product marketing . By using the internet, consumers are able to purchase goods or products freely without attachment time. The form of marketing on the Internet is known as e - commerce or electronic commerce. E commerce or electronic commerce is spread, purchasing, sales, marketing goods and services over electronic systems such as the Internet or television, www, or other computer networks such as the social media one. The more rapid development of e-commerce today is strongly influenced by the people's confidence in e –commerce.This study aims to determine consumer confidence ( ablity ,benevolence and integrity) of the purchase intention fashion products on the Facebook social media on student S1 FISIP Undip Semarang .Based on a simple regression analysis showed that the ability ( ability ) sellers a significant effect on consumer purchasing intention of fashion products , benevolence ( kindness ) shop online seller does not significantly influence consumers' purchasing intention of fashion products , integrity ( integrity ) shop online sellers a significant effect on purchase intentions consumer fashion products . The results of multiple regression showed that ablity , benevolence and integrity towards purchase intention poduk fashion on the Facebook social media simultaneously significant effect .Advice can be delivered in this study is an online shop needs to use some social media other than Facebook, need to pay attention to product quality, conformance with product photos, and timeliness need to be considered in serving the wishes of potential customers, need to improve in terms of honesty transaction.
AUDIT KOMUNIKASI LEMBAGA PEMERINTAH KECAMATAN TEMBALANG, KOTA SEMARANG
Authors: Yuliyanto Muchamad
Published: October 2022

Communication plays important role in the operation of an organization. Communication is able to push or block the productivity of an organization. Tembalang district government as organization that provide services to the community need good communication climate that can push members’s productivity to service community. This research aimed to examine the communication models and patterns in Tembalang district government. This research is a qualitative descriptive study. The research data was collected through in-depth interviews. The results showed that communication pattern applied in the organization has been highly affected by communication pattern and leadership style of its chief as the highest commander. Openness, egality, transparent, and giving sample as the applied communication style by the chief has been pushing organization members to respond the communication in an instance or passing through some leader’s levels.
EVALUASI PENERIMAAN CALON PEGAWAI NEGERI SIPIL DAERAH (CPNSD) PEMERINTAH PROPINSI JAWA TENGAH TAHUN 2013
Authors: Herawati Nunik Retno
Published: October 2022

Central Java Provincial Government in 2013 organized a Candidate Registration Regional Civil Servants (CPNSD) on line system. Selection is done by stages: Selection Administration and Basic Competence Test (TKD) through Computer Assisted Test (CAT) with the facilitation of the State Personnel Board (BKN) .The researchers have assumed that the acceptance CPNSD in Regional Government of Central Java Province in 2013 is better than the previous year. In general, the implementation CPNSD 2013 in Central Java Province has been implemented and run better when compared with the previous year CPNSD implementation. Indications are good transparency in the registration stage to the stage of graduation announcements. At the registration stage, the transparency shown by the use of the Internet media that can be accessed by all people. In the explanation, the public can see clearly the requirements and application procedures CPNSD. However, in the online registration is still frequently encountered obstacles such as the presence slowness internet access by prospective applicants CPNSD in Central Java. Acceptance CPNSD in Central Java in 2013 that uses CAT system has many advantages and can minimize cheating because its value can be directly known to be more objective, in addition to the basic competence test execution process faster, practical and efficient which will save costs.