bluuebunny/crossref_metadata_2025 huggingface dataset:
Possibilities of non-drug correction of menopausal disorders in women with metabolic syndrome: focus on prothrombogenic potential of the blood and pro-inflammatory status
Authors: Berihanova R. R. , Minenko I. A.
Published: May 2019

Aim. To study the dynamics of hemostasis, markers of systemic inflammation on the background of non-drug correction of menopausal disorders in women with metabolic syndrome (MS).

Material and methods. Three hundred thirty women 45-50 years old with MS and menopausal disorders are divided into 5 groups. Basic treatment received all women. In the study group and comparison groups, the following were included in the treatment program: physiotherapy exercises, drinking balneotherapy, oral multivitamins and minerals, as well as physical factors in various combinations (vibrotherapy, chromotherapy, melotherapy, aromatherapy, aero ionotherapy). The concentration of fibrinogen, C-reactive protein (CRP), hemostasis parameters were determined in dynamics.

Results. After 6 months of use of all medical complexes with physiotherapy in patients with menopausal syndrome of mild severity, a significant increase in the level of international normalized ratio (INR) was observed from 0,99 to 1,04, fibrinogen level regressed by 14,6-15,4%, CRP by 16,3-20,5% (p<0,05). In patients with climacteric syndrome of moderate severity, the best results were achieved when using the complex with a full set of all the listed factors: an increase in the INR level from 0,97 to 1,01, a decrease in the level of fibrinogen by 14,6%, and the CRP level — by 19,6% (p<0,05).

Conclusion. Polymodal programs, including physiotherapy, improve hemostasis, provide reducing the level of inflammatory markers. In moderate climacteric disorders, the priority is given to the program with simultaneous use of vibrotherapy, chromotherapy, melotherapy, aromatherapy and aeroionotherapy.
Determinantes del uso del crédito de vivienda por parte de los hogares bogotanos
Authors: Camelo Rincón Milton Samuel , Amaya Cárdenas Johnny Steven , Parra Guzmán John Fredy
Published: May 2019

El crédito hipotecario es reconocido en Colombia como una de las herramientas más utilizadas para obtener vivienda propia. Esta investigación identifica los principales determinantes del crédito hipotecario, y estima la influencia de factores como la educación, el ingreso y el empleo en la probabilidad de hacer uso efectivo de tal crédito por parte de los hogares bogotanos. Con tal propósito, se realiza una descripción del marco normativo del acceso a la vivienda y las condiciones de financiación establecidas por las principales entidades bancarias. Posteriormente, y con base en los datos recolectados por la encuesta multipropósito, realizada en 2014, para Bogotá, se estima un modelo Logit para establecer la probabilidad de uso del crédito para la compra de vivienda. Los resultados sugieren que la edad, el ingreso y la estabilidad laboral influyen significativamente sobre la decisión de uso de crédito; sin embargo, el factor más importante está dado por el nivel de educación.
Cell biology and histology in medicine: perception on education and student performance
Authors: Mantovani Ana Laura Sandoval , Lima Alba Regina De Abreu , Brienze Sérgio Luís Aparecido , Dos Santos Emerson Roberto , Fucuta Patrícia da Silva , André Júlio César
Published: May 2019

The subjects areas of Cellular Biology and Histology, which underpin the microscopic field of Morphology and are included in the first years of the curriculum in a Medical course, are the pillars of medical education  and for the clinical reasoning of future professionals. This study aimed to trace a teaching profile of Cellular Biology and Histology in the Medical courses which had participants in the selection process to fill vacancies by transfer, for the undergraduate course in the Medical School of São José do Rio Preto (FAMERP)  in 2017. This was a quantitative and qualitative cross-sectional study and 132 academics participated. The results showed that, in most Higher Education Institutions, these disciplines are taught theoretically and practically. In the comparison between the theoretical performance of the students of traditional and active teaching-learning methodology, a higher number of hits in Histology and a better final grade were observed in the traditional. The deficiency pointed out by the students was a lack of laboratory sessions with viewing histological glass slides with light microscopes. Also, the aspect of teachers’ pedagogical practice and dynamic classes was shown to be fundamental to the students' interest, as well as to better satisfaction’s index in learning these areas. Furthermore, integrating these disciplines with the clinical practice of Medicine has proved to be relevant for academics, who feel more instigated to knowledge. In the present study, it was detected a better use in relation to the Histology by the students of the courses of traditional methodology, compared to those of active methodology and in this way the analysis done can to collaborate for the enrichment and reaffirmation of the fruits of the comparison of teaching-learning methodologies.
Proceso de enseñanza aprendizaje para la proyección social en el programa de ingeniería mecánica de la Universidad Libre
Authors: SÁNCHEZ RODRÍGUEZ MARTHA CECILIA , MÁRQUEZ LASSO ISMAEL , MAGO RAMOS MARÍA GABRIELA
Published: May 2019

Esta investigación trata del proceso de enseñanzaaprendizaje de la Ingeniería Mecánica, enfocado dentro del marco de la proyección social enriquecida con una Cátedra de Emprendimiento que realiza la Universidad Libre de forma interdisciplinar, donde inicialmente los estudiantes asisten a la misma, y luego; estas competencias las concretan a través de un proyecto que debe tener carácter innovador acercando al estudiante hacia el emprendimiento social, cuya fundamentación requiere un enfoque técnico. Los estudiantes del programa de Ingeniería Mecánica, llevaron a cabo una investigación relacionada con el manejo de plástico de botellas desechadas por consumidores que inicialmente tienen una disposición para su recolección, y luego, podrán transformarse para su uso posterior, a través de equipos especiales diseñados por los estudiantes participantes como materia prima derivada, teniendo como resultado mejoras medioambientales contribuyendo con elementos que puedan aprovecharse como subproductos para la industria. Con una metodología técnica de transformación tecnológica en cada fase realizada, cuyos resultados fueron presentados en el VII ELEVATOR PITCH, como modelo de emprendimiento y cuya implementación es la orientación que persigue por parte de los alumnos participantes, mejorando las competencias en el área de Ingeniería Mecánica, específicamente, en Diseño y Manejo de Materiales como aporte a la tecnología y al compromiso con el desarrollo de la Ingeniería en Colombia.
Práticas Estratégicas de Internacionalização de Programas de Pós-Graduação: Estudo de Caso em uma Universidade Pública do Sul do Brasil
Authors: Neves Thayse Kiatkoski , Lavarda Rosalia Aldraci Barbosa , Martins Cibele Barsalini
Published: May 2019

A perspectiva da estratégia como prática social surgiu como uma das alternativas às pesquisas tradicionais na área de estratégia organizacional, passando a explicar a estratégia como algo que as pessoas fazem no seu dia a dia e não como uma propriedade das organizações. A internacionalização da pós-graduação brasileira se constitui em uma das principais metas do Sistema Nacional de Pós-Graduação. Nesse sentido, a perspectiva da estratégia como prática social pode ser utilizada para compreender as microdinâmicas relacionadas às estratégias de internacionalização dos programas de pós-graduação, como são efetivamente implementadas as ações e quem são os atores responsáveis por tais implementações. A partir da análise de programas stricto sensu considerados de excelência, segundo os critérios da CAPES, este estudo buscou compreender como se desenvolvem na prática cotidiana as estratégias de internacionalização de programas de pós-graduação stricto sensu de uma universidade pública federal que obtiveram nota máxima na Avaliação Trienal 2013 da CAPES. Adotou-se a metodologia qualitativa, a partir de um estudo de caso conduzido entre programas de uma universidade pública do sul do Brasil. Os resultados evidenciaram o papel de destaque assumido pelos docentes no processo de internacionalização dos programas. Também pode-se verificar que a estratégia acontece rotineiramente a partir do desenrolar das ações cotidianas dos programas abrangidos pelo estudo.
Estudo de Caso do Impacto de Ações Coletivas no Centro Musical Stop
Authors: Novo Jéssica , Silva Susana Costa e , Verdelho Vitor
Published: May 2019

O Centro Musical Stop tornou-se em três décadas a maior comunidade de músicos em Portugal, um fenómeno que tem vindo a ser estudado a nível nacional. No entanto, apesar do cluster que se formou neste espaço, não têm existido ações visíveis para promover o Stop e potencializar o crescimento dos músicos ali instalados.Torna-se, assim, relevante analisar este fenómeno ao nível das relações de cooperação existentes e da possibilidade de criação de ações coletivas com impacto positivo em clusters criativos não organizados. Para isso, recorreu-se à teoria das redes industriais e relações de cooperação, que têm sido objeto de estudo pelo Industrial Marketing and Purchasing Group.Este estudo de caso é uma investigação descritiva, que analisa os grupos: bandas e músicos; estúdios de produção; locais de atuação; e outros atores relevantes. Utilizaram-se entrevistas semiestruturadas numa amostra representativa da realidade em apreço.Nas conclusões são sugeridas ações coletivas para o crescimento e promoção do Stop como centro musical e de redes criativas semelhantes, com base no trabalho desenvolvido.
Çocuk ve adölesanlarda vücut kitle indeksi ortalama trombosit hacmini etkiler mi?
Authors: KARAKURT Neslihan , PELTEK KENDİRCİ Havva Nur
Published: May 2019

Amaç: Çocukluk çağındaki
obezite ile ortalama platelet volümünün (MPV) ilişkisini araştıran çalışmalar
daha çok adölesan dönemi içermektedir. Daha küçük yaştaki çocuklardaki
obezitenin MPV’ye etkisi ve yaşa göre zayıf hastalarda MPV değişiklikleri
tanımlanmamıştır.Bu çalışmanın birinci sonlanım noktası obez, yaşa göre normal ve
düşük VKİ’ne sahip çocuk ve adölesanlarda MPV değerlerinin incelenmesidir.Gereç ve Yöntemler: Üç yıllık hastane verilerinden
yararlanılarak çocuk endokrinoloji polikliniğine başvuran hastaların dosyaları
retrospektif incelendi. Hastalar vücut kitle indekslerine göre obes, normal ve
zayıf olarak gruplara ayrıldı. Grupların MPV değerleri kıyaslandı. Bulgular: Çalışmaya
dahil olan 261 çocuğun yaş ortalamaları 11,2± 3,7 (min:1,0, max:17,8) olup
%37,9 ‘u (n=99)  obez, %27,6’sı (n=72)
yaşa göre zayıf, %34,5 ‘i (n=90) ise normal ağırlıkta (kontrol grubu) bulundu.
Tüm hastaların hemoglobin ve MPV değerleri normal aralıkta olup obez ve kontrol
gruplarında yaşa göre zayıf gruba göre yüksek bulundu. Ayrıca insülin
direnci olan/ olmayanlar arasında da MPV değerleri arasına istatistiksel olarak
anlamlı bir fark tespit edilemedi.

Sonuç: Çalışmamızda
literatürden farklı olarak MPV değerinin zayıf çocuklarda normal kiloda ve obez
olanlara göre düşük, ancak hepsinde de normal aralıkta olduğunu saptadık.
İnsülin direncinin MPV değerlerine etkisi olmadığını gösterdik. MPV
değerlerinin klinik uygulamalarda yeri ile ilgili daha çok çalışmaya ihtiyaç
vardır.
Challenges and visions in school music education: Focusing on Chinese and Lithuanian realities
Authors: Lasauskiene Jolanta , Sun Youdi
Published: May 2019

This article focuses on music education in Chinese and Lithuanian schools, especially on the latest reforms of the national music curriculum for basic and general education. Due to the original reasons and historical development in the east and west, the philosophies of educations are different, resulting in differences in concepts of education, goals of education, methods of education, roles of teachers and students. The process of collecting information for music education in Lithuania and China will be explained in order to gain insight into specific issues related to each country. The resulting similarities and differences between Chinese and Lithuanian school music education are reported, and suggestions for basic and teacher education improvement are discussed. Most importantly, the findings of this study have highlighted that the notions of school music education in Lithuania and China are insignificantly different.

Keywords: Chinese general music education, music curriculum, music activities, Lithuanian general music education.
Validation of a questionnaire to measure job expectations and interests in university students
Authors: Jimenez Miguel Angel Fernandez , Rodriguez Esther Mena , Carrillo Victoria del Rocio Gomez
Published: May 2019

The establishment of the European Higher Education Area has promoted an attempt to design a syllabus that is more related to the world of work. There is evidence to suggest that the transfer of skills that should be acquired by students throughout their university courses is not carried out in an appropriate way that prepares them for working life. In view of this, it is essential to understand university studentsâ€™ perceptions and assessments of relevant aspects of their entry into the labour market. To this end, an instrument was designed to evaluate university studentsâ€™ perception and assessment of future employment. In order to verify the reliability and measurement validity of the questionnaire, a pilot study was carried out with a sample of a total of 220 university students. The analyses carried out have proved the quality of the instrument in terms of adequate reliability and measurement validity.

Keywords: Evaluation questionnaire, labour insertion, labour expectations, reliability, validity.
School choice and private schooling: a comparative case-study between Greece and Sweden
Authors: Farazouli Alexandra
Published: May 2019

Over the past three decades, privatisation and school choice have been introduced and embodied in the vocabulary of several national education policies. This study aiming to examine the phenomenon of private schooling and the factors that affect parental school choice outlined a comprehensive framework of the national policies about private schools and school choice in Greece and Sweden. The case study design of the research provided an in-depth exploration of the two national contexts, enriching the study with empirical data. Twenty semi-structured interviews with education professionals and parents from both countries shed light on the reasons behind the school choice towards private schools. Regarding the findings of the research, several kinds of educational inequalities and social segregation were identified because of the fact that not all parents have access to school choice under equal terms.

Keywords: School choice, private education, human capital theory, human rights theory, capability approach
How does cyberbullying affect the values of university youth?: Its' analysis in terms of education and mental health
Authors: Isik Burcin , Ozdemir Nurgul
Published: May 2019

Cyberbullying is a systematic abuse of power which occurs through the use of information and communication technologies (ICTs). Research on cyberbullying shows that cyberbullying and victimisation have very serious negative effects on the value judgements, social, academic and emotional lives of young people. Persons exposed to cyberbullying include intense sadness and depression, feelings of fear and shame, tense experience, high or very low alertness, low interest in ICTs tools, problematic behaviours, decrease in school success, use of harmful substances or inconvenience, crime, substance abuse, frustration, anger, anxiety, loss of motivation, academic failure, school absenteeism and problems that can lead to suicide. The studies on cyberbullying will encourage young people to recognise this concept and use the technology in the right direction to cope with cyberbullying situations.

Keywords: Cyberbullying, university youth, education, mental health, technology
An investigation of L2 motivational self-system and intercultural communicative competence of pre-service English teachers': Kazakhstani perspective
Authors: Gelisli Yucel , Kazykhankyzy Lazura
Published: May 2019

This study aimed to explore the relationship between L2 motivational self-system (ideal L2 self and ought to L2 self) and intercultural communicative competence (ICC) among pre-service teachers of English in Kazakhstan. Moreover, the predicting effect of ought to self and ideal self on participants ICC was examined. Quantitative methods of data analysis were used to analyse the data. The ICC scale developed by the researcher and L2 motivational self-system scale developed by Taguchi, Magid and Papi were used to collect the data. The data were collected from 307 major student-teachers' of English language teaching departments from Akhmet Yassawi and Auezov South Kazahstan State Universities. Descriptive analyses (means, standard deviations), Mann - Whitney U test, one-way analysis of variance, Kruskal - Wallis H test, Spearman rank-order correlation coefficient and regression analysis were performed to analyse the data.
Keywords: ICC, L2 motivational self-system, pre-service English teachers.
Effects of Resistance and Combined training on Vascular Function in Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials
Authors: Dos Santos Araujo João E. , Nunes Macedo Fabrício , Sales Barreto André , Viana dos Santos Márcio R. , Antoniolli Angelo R. , Quintans-Junior Lucindo J.
Published: May 2019

BACKGROUND: Cardiovascular disease (CVD) is the main cause of mortality in type 2 diabetes (T2D). Exercise can reduce the risk factors associated with CVD in T2D patients. However, research evaluating its beneficial effects in these patients has used different measurement protocols
and types of exercise, complicating comparison. AIM: To assess the effects of resistance training (RT) and combined training (CT) on the vascular function of T2D patients. METHODS: A database search (MEDLINE, Scopus, and Web of Science) was performed to identify relevant articles
that were published up to August 2017. Only original studies evaluating the effects of RT or CT interventions on vascular function in T2D patients were included. The articles were reviewed independently by at least three reviewers. The Cochrane guidelines were used to assess the methodological
quality of the studies. Fourteen studies were finally included. Two studies only used RT and twelve studies used CT as intervention strategy. RESULTS and CONCLUSIONS: The results show that resistance training is a useful means for primary treatment of vascular diseases and maintenance
of vascular function in T2D patients. However, more studies are necessary to gain full knowledge of the beneficial effects and to identify tailored exercise plans to optimize these benefits. The information provided in this review may help to improve current treatment of vascular diseases
in T2D patients and to design future studies.
It’s not you, it’s the design - common problems with patient monitoring reported by anesthesiologists: a mixed qualitative and quantitative study.
Authors: Tscholl David , Handschin Lucas , Rössler Julian , Weiss Mona , Spahn Donat R. , Nöthiger Christoph B.
Published: May 2019

BACKGROUND
Patient monitoring is critical for perioperative patient safety as anesthesiologists routinely make crucial therapeutic decisions from the information displayed on patient monitors. Previous research has shown that today's patient monitoring has room for improvement in areas such as information overload and alarm fatigue. The rationale of this study was to learn more about the problems anesthesiologists face in patient monitoring and to derive improvement suggestions for next-generation patient monitors.

METHODS
We conducted a two-center qualitative/quantitative study. Initially, we interviewed 120 anesthesiologists (physicians and nurses) about the topic: common problems with patient monitoring in your daily work. Through deductive and inductive coding, we identified major topics and sub themes from the interviews. In a second step, a field survey, a separate group of 25 anesthesiologists rated their agree- or disagreement with central statements created for all identified major topics.

RESULTS
We identified the following six main topics: 1. "Alarms," 2. "Artifacts," 3. "Software," 4. "Hardware," 5. "Human Factors," 6. "System Factors," and 17 sub themes. The central statements rated for the major topics were: 1. “problems with alarm settings complicate patient monitoring.” (96% agreed) 2. “artifacts complicate the assessment of the situation.” (56% agreed) 3. “information overload makes it difficult to get an overview quickly.” (56% agreed) 4. “problems with cables complicate working with patient monitors.” (88% agreed) 5. “factors related to human performance lead to critical information not being perceived.” (64% agreed) 6. “Switching between monitors from different manufacturers is difficult.” (88% agreed). The ratings of all statements differed significantly from neutral opinion (all p<0.03).

CONCLUSION
This study provides an overview of the problems anesthesiologists face in patient monitoring. Some of the issues, to our knowledge, were not previously identified as common problems in patient monitoring, e.g., hardware problems (e.g., cable entanglement and worn connectors), human factor aspects (e.g., fatigue and distractions), and systemic factor aspects (e.g., insufficient standardization between manufacturers). An ideal monitor should transfer the relevant patient monitoring information as efficiently as possible, prevent false positive alarms, and use technologies designed to improve the problems in patient monitoring.
Propofol attenuated the effect of TNF-α on occludin expression by inhibiting HIF-1α/VEGF/VEGFR-2/ERK signaling pathway in hCMEC/D3 cells
Authors: Zhang Yue , Ding Xiaowei , Miao Changhong , Chen Jiawei
Published: May 2019

Purpose: The levels of tight junction proteins (TJs), especially occludin correlate with blood-brain barrier (BBB) disruption caused by central nervous system (CNS) inflammation during perioperative period. It has been reported that propofol, the most commonly used anesthetic, could inhibit inflammation response in CNS. In this study, we investigated the effects of TNF-α and propofol on occludin expression in human cerebral microvascular endothelial cell line, D3 clone (hCMEC/D3 cells), and explored the underlying mechanisms.
Methods: The hCMEC/D3 cells were treated with propofol, followed by TNF-α. The expression and phosphorylation of Hif-1α, VEGF, VEGFR-2, ERK and occludin were measured by Western blot analysis. The in vitro cell viability of hCMEC/D3 cells was measured by cell counting kit-8.
Results: TNF-α (10 ng/ml, 4 h) significantly decreased the expression of occludin, which was attenuated by propofol (25 μM). TNF-α induced Hif-1α/VEGF/VEGFR-2/ERK signaling pathway, while propofol could inhibit it. In addition, the inhibitors of Hif-1α, VEGF, VEGFR-2, and ERK could reduce the effect of TNF-α on occludin expression.
Conclusion: TNF-α could decrease the expression of occludin via Hif-1α/VEGF/VEGFR-2/ERK signaling pathway, which was attenuated by propofol.
Using multi-temporal analysis to classify monthly precipitation based on maximal overlap discrete wavelet transform
Authors: Roushangar Kiyoumars , Alizadeh Farhad
Published: May 2019

In the present study, a hybrid methodology was proposed in which temporal pre-processing and spatial classification approaches were used in a way to take advantage of multiscale properties of precipitation series. Monthly precipitation data (1960–2010) for 31 rain gauges were used in the proposed classification approaches. Maximal overlap discrete wavelet transform (MODWT) was used to capture the time–frequency attributes of the time series and multiscale regionalization was performed by using self-organizing maps (SOM) clustering model. Daubechies 2 function was selected as mother wavelet to decompose the precipitation time series. Also, proper boundary extensions and decomposition level were applied. Different combinations of the wavelet (W) and scaling (V) coefficients were used to determine the input dataset as a basis of spatial clustering. Four input combinations were determined as single-cycle and the remaining four combinations were determined with multi-temporal dataset. These combinations were determined in a way to cover all possible scales captured from MODWT. The proposed model's efficiency in spatial clustering stage was verified using Silhouette Coefficient index. Results demonstrated superior performance of MODWT-SOM in comparison to historical-based SOM approach. It was observed that the clusters captured by MODWT-SOM approach determined homogenous precipitation areas very well (based on physical analysis).
New Mechanistic Insight on the PIM-1 Kinase Inhibitor AZD1208 Using Multidrug Resistant Human Erythroleukemia Cell Lines and Molecular Docking Simulations
Authors: Marques Maiara Bernardes , González-Durruthy Michael , da Silva Nornberg Bruna Félix , Oliveira Bruno Rodrigues , Almeida Daniela Volcan , de Souza Votto Ana Paula , Marins Luis Fernando
Published: May 2019

Background:

PIM-1 is a kinase which has been related to the oncogenic processes like cell survival, proliferation, and multidrug resistance (MDR). This kinase is known for its ability to phosphorylate the main extrusion pump (ABCB1) related to the MDR phenotype.

Objective:

In the present work, we tested a new mechanistic insight on the AZD1208 (PIM-1 specific inhibitor) under interaction with chemotherapy agents such as Daunorubicin (DNR) and Vincristine (VCR).

Materials and Methods:

In order to verify a potential cytotoxic effect based on pharmacological synergism, two MDR cell lines were used: Lucena (resistant to VCR) and FEPS (resistant to DNR), both derived from the K562 non-MDR cell line, by MTT analyses. The activity of Pgp was ascertained by measuring accumulation and the directional flux of Rh123. Furthermore, we performed a molecular docking simulation to delve into the molecular mechanism of PIM-1 alone, and combined with chemotherapeutic agents (VCR and DNR).

Results:

Our in vitro results have shown that AZD1208 alone decreases cell viability of MDR cells. However, co-exposure of AZD1208 and DNR or VCR reverses this effect. When we analyzed the ABCB1 activity AZD1208 alone was not able to affect the pump extrusion. Differently, co-exposure of AZD1208 and DNR or VCR impaired ABCB1 activity, which could be explained by compensatory expression of abcb1 or other extrusion pumps not analyzed here. Docking analysis showed that AZD1208 is capable of performing hydrophobic interactions with PIM-1 ATP- binding-site residues with stronger interaction-based negative free energy (FEB, kcal/mol) than the ATP itself, mimicking an ATP-competitive inhibitory pattern of interaction. On the same way, VCR and DNR may theoretically interact at the same biophysical environment of AZD1208 and also compete with ATP by the PIM-1 active site. These evidences suggest that AZD1208 may induce pharmacodynamic interaction with VCR and DNR, weakening its cytotoxic potential in the ATP-binding site from PIM-1 observed in the in vitro experiments.

Conclusion:

Finally, the current results could have a pre-clinical relevance potential in the rational polypharmacology strategies to prevent multiple-drugs resistance in human leukemia cancer therapy.
Applications of Bioorthogonal Chemistry in Tumor-Targeted Drug Discovery
Authors: Liu Gang , Wold Eric A. , Zhou Jia
Published: May 2019

:
Cirrhotic Cardiomyopathy: The Interplay Between Liver and Cardiac Muscle. How Does the Cardiovascular System React When the Liver is Diseased?
Authors: Dourakis Spyros P. , Geladari Eleni , Geladari Charalampia , Vallianou Natalia
Published: May 2019

:

It is widely known that liver cirrhosis, regardless of the etiologies is accompanied by severe
hemodynamic changes. The principal pathophysiological mechanisms are the hyperdynamic
circulation with increased cardiac output, heart rate along with reduced systemic vascular resistance.
Thus, counteractive mechanisms may develop that eventually lead to systolic as well as diastolic dysfunction
and rhythm disturbances, in order to keep a steady homeostasis in the human body.

:

Literally, blunted contractile responsiveness to physical or pharmacological stress, impaired diastolic
relaxation and electrophysiological changes, primarily QT interval prolongation, do occur
progressively in a cirrhotic patient with no known preexisting cardiac disease. This condition is
identified as cirrhotic cardiomyopathy (CCM), an entity different from that seen in alcoholic cardiac
muscle disease.

:

For the past decades, clinicians did study and attempt to understand the pathophysiology and clinical
significance of this process. Indeed, various factors have been identified acting at the molecular
and cellular level.

:

Electrocardiography, echocardiography and various serum biomarkers are the main tools that help
healthcare practitioners to point to the correct diagnosis.

:

Noteworthy, the subjects that suffer from cirrhotic cardiomyopathy may progress to heart failure
during invasive procedures such as surgery, insertion of a transjugular intrahepatic portosystemic
shunting (TIPS) and liver transplantation. Besides, several studies have illustrated that CCM is a
contributing factor, or even a precipitant, of hepatorenal syndrome (HRS), a conceivable reversible
kidney failure in patients with liver cirrhosis and ascites.

:

The treatment is the same as it is in the patients with liver cirrhosis and heart failure and there is no
particular treatment for cirrhotic cardiomyopathy. Hence, it is of utmost importance to clearly comprehend
the pathophysiology of this disease in order to design more accurate diagnostic tools and
definitive treatments in a way to prevent the complications of cirrhosis and overt heart failure.

:

The objective of this review is to describe in a comprehensive way the pathological alterations that
occur in the cardiovascular system of cirrhotic patients. It will also point the limitations that remain in
the diagnosis and treatment strategies and more importantly, this review will alert the clinicians in the
modern era to further observe and record additional pathological changes in this subset of patients.
A Marine-based Meriolin (3-Pyrimidinylazaindole) Derivative (4ab) Targets PI3K/AKT /mTOR Pathway Inducing Cell Cycle Arrest and Apoptosis in Molt-4 Cells
Authors: Chashoo Gousia , Singh Umed , Singh Parvinder P. , Mondhe Dilip M. , Vishwakarma Ram A.
Published: May 2019

Background:

Cyclin-dependent kinases play a central role in the control of cell division
and therefore it is not surprising that cancer exhibits some features that disturb the normal controls
over the cell cycle. Previous studies related to the development of 3-Pyrimidinylazaindole (Meriolin)
derivatives as novel Cyclin dependent kinase inhibitors highlighted 4ab as the most potent inhibitor.

Objective:

The main objective of the current study was to understand the mode of cell death and the
effect of 4ab on major cellular networking pathways in cancer.

Method:

Preliminary apoptotic studies were carried out using flowcytometer and electron microscope.
The effect on cellular signalling was studied via western blotting.

Results:

4ab was found to inhibit the enzymatic activity of CDK2. The inhibition of CDK2 activity
was found to be associated with the down-regulation of P-cdc-25 and arrest of cells in G0-G1 phase of
the cell cycle in lymphoblastic leukemia cells. Further, 4ab was found to affect AKT-mToR pathway
by down-regulating the expression of major proteins including P-m-TOR (2448), P110α, P-AKT
(S473) and P-p-70S6K.

Conclusion:

Current study shows that the potent anticancer potential of 4ab is mediated via cellular
apoptosis, dysregulation of mitochondrial membrane potential and arrest of G1 phase in Molt-4 cells.
Further, target-based studies showed the effect of 4ab on one of the major cellular signalling pathways
deregulated in cancer.
IDENTIFICATION AND ASSESSMENT OF HIGH-PRODUCTIVITY PLANT PRODUCTION PLANNING PROCESS RISKS
Authors: Skorniakova E. A. , Sulaberidze V. Sh. , Boreysho A. S. , Luginya V. S.
Published: May 2019

Analysis of production planning process was done: model of process described with applying of IDEF0 methodology, problems of production planning process listed and also risks of developed process identified. Risk assessment conducted by two methods – critical level ranking by experts and FMEA. Calculation results of Kendall coefficient of concordance and Spearmen criterion showed consistency of expert opinions and comparability of the level of assessed risks criticality. The most critical risks include risks related with mistakes in provided data and created plan and also risk of provided data unreliability. A key way of identified risks elimination is automating of studied process. After development of automated planning system and implementation of all methods for risks elimination or minimization, risk of wrong data entry into the system was assessed by HRA method.
SYNTHESIS OF TWO-POINT PARTIALLY COHERENT MODEL, PROVIDING SPECIFIED CORRELATION CHARACTERISTICS OF ANGULAR NOISE, BASED ON ITS EQUIVALENCE OF THREE-POINT NON-COHERENT MODEL WITH SEPARABILITY OF SPATIAL AND TEMPORAL COORDINATES
Authors: Podkopayev A. O. , Stepanov M. A.
Published: May 2019

The paper considers approaches developed for the synthesis of a two-point geometric model that emits correlated signals and forms angular noise with given spectral-correlation properties, based on its equivalence of a three-point model that emits noncorrelated signals. Analytical relationships have been obtained that allow us to determine the spectral correlation characteristics of the signals supplied to the emitters of the two-point partially coherent model. The basis for the synthesis of a two-point model, emitting correlated signals, is a three-point model, emitting non-correlated signals. The considered models can replace a one-dimensional object that has the property of separating the spatial and temporal variables in functions that determine the distribution of the density of the auto- and cross-correlation quadrature components of the echo signal over the object. In this case, all points of the object being replaced reflect echoes with the same spectral and correlation properties. The obtained theoretical results are confirmed by digital modeling. The obtained probability density distributions of the angular noise and their correlation functions coincide for the two considered models.
CONNECTION OF ANGULAR DIMENSIONS OF SIMULATED DISTRIBUTED OBJECTS WITH PARAMETERS OF DISTRIBUTION OF THEIR ANGULAR NOISE
Authors: Artyushenko V. V. , Nikulin A. V.
Published: May 2019

Fluctuations of the apparent center of radiation near their expectation during the irradiation of distributed objects with probing signals from radar stations have been observed by scientists for many decades. An expression describing the statistical nature of such fluctuations is known in the literature. These fluctuations are called angular noise. With all this, there is still no expression connecting the angular dimensions of the object and the distribution parameters of its angular noise. This expression is necessary to predict the angular size of distributed objects in problems of simulating reflections from them. In the article, the problem indicated above is solved in two ways. When using the first method, it is possible to obtain an unambiguous relationship between the angular size of the object and the distribution parameters of its angular noise, but for each new object it is necessary to re-derive this relationship, which is not always possible. When using the second method, the probability is used with which the fluctuating apparent center of radiation of a signal reflected from a distributed object falls within the boundaries of this object. This method has no disadvantage of the first one. The results presented in this article were confirmed by means of mathematical modeling.
SIMULATION OF ECHO SIGNALS OF TWO-POSITION SYSTEMS USING COHERENT EMITTERS
Authors: Sabitov T. I. , Kiselev A. V.
Published: May 2019

The paper deals with the task of simulating echo signals of a radar system for two-position systems. Relations have been obtained for calculating the coordinates of the emitters of a matrix simulator in the form of a system that satisfies the conditions of in-phase conditions of signals at two receiving points. The condition of signal synchronization is achieved when the difference in distance from the emitters of the matrix to the receiving points is an integer number of wavelengths. Based on the obtained relations, an iterative algorithm for the formation of a matrix of coherent emitters has been developed, which allows synthesizing matrices of any sizes. An example of the implementation of the iterative algorithm showed that by selecting the values of the distances from the matrix emitters to the receiving points, the emitters can be located almost on one line. The obtained theoretical results are confirmed by numerical simulation data.
SPEECH RECOGNITION BASED ON CONVOLUTION NEURAL NETWORKS
Authors: Belorutsky R. Yu. , Zhitnik S. V.
Published: May 2019

The problem of recognizing a human speech in the form of digits from one to ten recorded by dictaphone is considered. The method of the sound signal spectrogram recognition by means of convolutional neural networks is used. The algorithms for input data preliminary processing, networks training and words recognition are realized. The recognition accuracy for different number of convolution layers is estimated. Its number is determined and the structure of neural network is proposed. The comparison of recognition accuracy when the input data for the network is spectrogram or first two formants is carried out. The recognition algorithm is tested by male and female voices with different duration of pronunciation.
ALGORITHM FOR CALCULATING SURFACES OF BIFOCAL LENS ANTENNAS
Authors: Nikulina Yu. S.
Published: May 2019

An algorithm is proposed that makes it possible to calculate the coefficients of power polynomials approximating the illuminated and shadow surfaces of bifocal lens antennas. The algorithm is based on providing equality of electrical lengths of rays passing from the focus points through lens body and its edge and on the assumption that the phase front is flat and is inclined at a determined angle relative to the main optical axis of the lens on the aperture of the lens antenna. For each of the rays an expression was written that determines its electrical length. The electrical length of the rays depends on the points coordinates of the illuminated and shadow surface of the lens, in which they are refracted. The analytical solution of the obtained equation is difficult. Therefore, it is proposed to determine the exact coordinate values by numerical methods. The proposed algorithm determines in series the three points lying on the illuminated and shadow surfaces. The coordinates of the points are used to form systems of equations whose solutions are the coefficients of power polynomials approximating the illuminated and shadow surfaces of the lens antenna. The algorithm does not impose restrictions on the relative dielectric constant of the material from which the lens antenna is made.
QUASI-ELLIPTIC MICROSTRIP FILTER
Authors: Razinkin V. P. , Aubakirov K. Ya. , Serikov T. G.
Published: May 2019

Currently, modern telecommunication and radio-electronic systems widely use wireless information transmission technologies over the radio channel. Therefore, an urgent task is to ensure electromagnetic compatibility of a large number of simultaneously operating radio facilities using high-selective bandpass filters. This paper presents circuit solutions for microstrip filters using incomplete inclusion of loads and communication elements. This construction makes it possible to obtain additional attenuation poles in the near zone of the stop band, which frequencies are determined by the load inclusion factor. It is proposed to include a capacitor in the middle of the microstrip communication line to improve the selective properties. This made it possible to increase the order of the filter at constant dimensions. The frequency characteristics of a high-selective quasi-elliptic filter are given.
Examining Cost Measurements in Production and Delivery of Three Case Studies Using E-Learning for Applied Health Sciences: Cross-Case Synthesis
Authors: Meinert Edward , Alturkistani Abrar , Foley Kimberley A , Brindley David , Car Josip
Published: May 2019

Background

The World Health Report (2006) by the World Health Organization conveys that a significant increase is needed in global health care resourcing to meet the current and future demand for health professionals. Electronic learning (e-Learning) presents a possible opportunity to change and optimize training by providing a scalable means for instruction, thus reducing the costs for training health professionals and providing patient education. Research literature often suggests that a benefit of e-Learning is its cost-effectiveness compared with face-to-face instruction, yet there is limited evidence with respect to the comparison of design and production costs with other forms of instruction or the establishment of standards pertaining to budgeting for these costs.

Objective

To determine the potential cost favorability of e-Learning in contrast to other forms of learning, there must first be an understanding of the components and elements for building an e-Learning course. Without first taking this step, studies lack the essential financial accounting rigor for course planning and have an inconsistent basis for comparison. This study aimed to (1) establish standard ingredients for the cost of e-Learning course production and (2) determine the variance instructional design has on the production costs of e-Learning courses.

Methods

This study made use of a cross-case method among 3 case studies using mixed methods, including horizontal budget variance calculation and qualitative interpretation of responses from course designers for budget variance using total quality management themes. The different implementation-specific aspects of these cases were used to establish common principles in the composition of budgets in the production and delivery of an applied health professional e-Learning course.

Results

A total of 2 case studies reported significant negative budget variances caused by issues surrounding underreporting of personnel costs, inaccurate resource task estimation, lack of contingency planning, challenges in third-party resource management, and the need to update health-related materials that became outdated during course production. The third study reported a positive budget variance because of the cost efficiency derived from previous implementation, the strong working relationship of the course project team, and the use of iterative project management methods.

Conclusions

This research suggests that the delivery costs of an e-Learning course could be underestimated or underreported and identifies factors that could be used to better control budgets. Through consistent management of factors affecting the cost of course production, further research could be undertaken using standard economic evaluation methods to evaluate the advantages of using e-Learning.
A Pain eHealth Platform for Engaging Obese, Older Adults with Chronic Low Back Pain in Nonpharmacological Pain Treatments: Protocol for a Pilot Feasibility Study (Preprint)
Authors: Brooks Amber K , Miller Jr David P , Fanning Jason T , Suftin Erin L , Reid M Carrington , Wells Brian J , Leng Xiaoyan , Hurley Robert W
Published: May 2019

BACKGROUND

Low back pain is a costly healthcare problem and the leading cause of disability among adults in the United States. Primary care providers urgently need effective ways to deliver evidence-based, nonpharmacological therapies for chronic low back pain. Guidelines published by several government and national organizations have recommended nonpharmacological and nonopioid pharmacological therapies for low back pain.

OBJECTIVE

The Pain eHealth Platform (PEP) pilot trial aims to test the feasibility of a highly innovative intervention that (1) uses an electronic health record (EHR) query to systematically identify a phenotype of obese, older adults with chronic low back pain who may benefit from Web-based behavioral treatments; (2) delivers highly tailored messages to eligible older adults with chronic low back pain via the patient portal; (3) links affected patients to a Web app that provides education on the efficacy of evidence-based, nonpharmacological, behavioral pain treatments; and (4) directs patients to existing Web-based health treatment tools.

METHODS

Using a three-step modified Delphi method, an expert panel of primary care providers will define a low back pain phenotype for an EHR query. Using the defined low back pain phenotype, an EHR query will be created to identify patients who may benefit from the PEP. Up to 15 patients with low back pain will be interviewed to refine the tailored messaging, esthetics, and content of the patient-facing Web app within the PEP. Up to 10 primary care providers will be interviewed to better understand the facilitators and barriers to implementing the PEP, given their clinic workflow. We will assess the feasibility of the PEP in a single-arm pragmatic pilot study in which secure patient portal invitations containing a hyperlink to the PEP Web app are sent to 1000 patients. The primary outcome of the study is usability as measured by the System Usability Scale.

RESULTS

Qualitative interviews with primary care providers were completed in April 2019. Qualitative interviews with patients will begin in December 2019.

CONCLUSIONS

The PEP will leverage informatics and the patient portal to deliver evidence-based nonpharmacological treatment information to adults with chronic low back pain. Results from this study may help inform the development of Web-based health platforms for other pain and chronic health conditions.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/14525