bluuebunny/crossref_metadata_2025 huggingface dataset:
No short polynomials vanish on bounded rank matrices
Authors: Draisma Jan , Kahle Thomas , Wiersig Finn
Published: February 2023

We show that the shortest non‐zero polynomials vanishing on bounded‐rank matrices and skew‐symmetric matrices are the determinants and Pfaffians characterising the rank. Algebraically, this means that in the ideal generated by all ‐minors or ‐Pfaffians of a generic matrix or skew‐symmetric matrix, one cannot find any polynomial with fewer terms than those determinants or Pfaffians, respectively, and that those determinants and Pfaffians are essentially the only polynomials in the ideal with that many terms. As a key tool of independent interest, we show that the ideal of a very general ‐dimensional subspace of an affine ‐space does not contain polynomials with fewer than  terms.
Evaluation of Resonance Frequency and Micromotion to Achieve Implant Stability Using Vibroacoustic Resonance Frequency Analysis: A Mathematical Model
Authors: Khened Vineet , Dhok Kanad , Pradhan Mahesh , Dhatrak Pankaj
Published: February 2023

Dental implants are surgically implanted into the patient's jaw to replace a missing tooth. The implant should have adequate time to integrate with bone before being subjected to masticatory force to avoid early failure. Resonance frequency analysis (RFA) is one of the approaches for determining an implant system's primary stability in terms of micromotion. This research aims to create a two degrees-of-freedom (DOF) mathematical model for dental prostheses based on the vibroacoustic RFA approach. In vibroacoustic system, a loudspeaker or buzzer is used as an input and the displacement of implant is measured using RFA. A sinusoidal force is used which produces a combination of translational and rotational motion of the implant system. While adjusting the input frequency from 4000 to 12,000 Hz, is used with the help of matlab which later computes the implant system's subsequent micromotion and resonance frequency. matlab is used to visualize the resonance frequency, which is 6658.38 Hz in case of rotational motion and 8138 Hz in translational motion. The micromotion was 1.2692 × 10−11 m in case of translational motion and 6.91088 × 10−9 radians in case of rotational motion. When there is less micromotion, a higher resonance frequency suggests more excellent osseointegration. For the evaluation of implant stability, a mathematical model is a primary approach that can be implemented to design a stability device using vibroacoustic RFA.
Evaluation of Soft Mist Inhaler Aerosol Velocity, Size, and Deposition Inside the Mouth—A Computational Fluid Dynamics Study
Authors: Sadeghi Taha , Pakzad Leila , Fatehi Pedram
Published: February 2023

Respiratory diseases debilitate more than 250 million people around the world. Among available inhalation devices, the soft mist inhaler (SMI) is the most efficient at delivering drugs to ease respiratory disease symptoms. In this study, we analyzed the SMI performance in terms of the aerosol's velocity profiles, flow pattern, size distribution, and deposition by employing computational fluid dynamics (CFD) simulations. We modeled two different simplified mouth geometries, idealized mouth (IM), and standard mouth (SM). Three different locations (x = 0, x = 5, and x = 10 mm) for the SMI nozzle orifice were chosen along the mouth cavity centerlines, followed by two different SMI nozzle angles (10 deg and 20 deg) for IM geometry. A flowrate of 30 L/min was applied. The simulation results were evaluated against experimental data. It was found that the SMI could be simulated successfully with a level of error of less than 10%. The inhalation flowrate significantly impacted the aerosol's velocity profile and deposition efficiency on both the IM and SM walls. The lowest particle deposition on the mouth wall occurred when a fixed flowrate (30 L/min) was applied inside both geometries, and the SMI nozzle position moved forward to x = 10 mm from the IM and SM inlets. An increase in the SMI nozzle angle increased particle deposition and decreased the deposition fraction for particles with a diameter above 5 μm inside the IM.
Mechanical Erosion Investigation in Solid Rocket Motor Nozzle Through Droplet Breakup and Surface Tension Influence
Authors: Abousabae Mohamed , Amano Ryoichi S.
Published: February 2023

Erosion prediction of the solid propellent nozzle is vital for its design process. This erosion is caused by the impingement of agglomerated aluminum/aluminum oxide particles on the nozzle walls. Thus, a multi-phase numerical model is established based on the Eulerian–Lagrangian approach to model the aluminum particles burning inside the combustion chamber and simulate the mechanical erosion of the nozzle. The numerical model is validated against numerical and experimental results from the literature. Then it is simplified by eliminating the aluminum particles burning process as they do not reach the nozzle. The simplified model will be further used in modeling the agglomerates’ breakup and predicting the mechanical erosion for aluminum particles with lower surface tension. The results showed that applying the Reitz–Diwakar breakup model reduces the erosion rate by 6.2–24% depending on the injected droplets. In addition, it was found that a decrease in the erosion rate by 1–4.5% can be achieved by reducing the aluminum additive’s surface tension by 15%.
Multiclass Reinforced Active Learning for Droplet Pinch-Off Behaviors Identification in Inkjet Printing
Authors: Li Zebin , Segura Luis Javier , Li Yifu , Zhou Chi , Sun Hongyue
Published: February 2023

Inkjet printing (IJP) is one of the promising additive manufacturing techniques that yield many innovations in electronic and biomedical products. In IJP, the products are fabricated by depositing droplets on substrates, and the quality of the products is highly affected by the droplet pinch-off behaviors. Therefore, identifying pinch-off behaviors of droplets is critical. However, annotating the pinch-off behaviors is burdensome since a large amount of images of pinch-off behaviors can be collected. Active learning (AL) is a machine learning technique which extracts human knowledge by iteratively acquiring human annotation and updating the classification model for the pinch-off behaviors identification. Consequently, a good classification performance can be achieved with limited labels. However, during the query process, the most informative instances (i.e., images) are varying and most query strategies in AL cannot handle these dynamics since they are handcrafted. Thus, this paper proposes a multiclass reinforced active learning (MCRAL) framework in which a query strategy is trained by reinforcement learning (RL). We designed a unique intrinsic reward signal to improve the classification model performance. Moreover, how to extract the features from images for pinch-off behavior identification is not trivial. Thus, we used a graph convolutional network for droplet image feature extraction. The results show that MCRAL excels AL and can reduce human efforts in pinch-off behavior identification. We further demonstrated that, by linking the process parameters to the predicted droplet pinch-off behaviors, the droplet pinch-off behavior can be adjusted based on MCRAL.
Implementation of Precision Machine Tool Thermal Error Compensation in Edge-Cloud-Fog Computing Architecture
Authors: Zhang Lin , Ma Chi , Liu Jialan , Gui Hongquan , Wang Shilong
Published: February 2023

The implementation of precision machine tool thermal error compensation in edge-cloud-fog computing architecture has the potential to control the thermal error. However, the challenges faced by the successful implementation are described as follows: The data collection and transfer efficiency are low, and the control accuracy is not deficient. To address these challenges, a hardware design scheme is proposed for the high-performance intelligent gateway node based on the low-power processor architecture of ARM Cortex-A7. Moreover, a new transformer-improved-gate long short-term memory model is proposed, and then it is embedded into edge-cloud-fog computing architecture. With the implementation of gear profile grinding machine thermal error compensation in edge-cloud-fog computing architecture, the maximum values of the tooth profile tilt deviation are reduced from 17.4 μm to 5.4 μm and from 17.9 μm to 5.8 μm for the left and right tooth flanks, respectively. Moreover, the maximum values of the tooth profile deviation are reduced from 18.9 μm to 6.1 μm and from 18.2 μm to 5.8 μm for the left and right tooth flanks, respectively. Compared with the traditional collection mode, the response delay of the designed intelligent gateway in the acquisition mode is reduced by 40%.
What happens under the flexor tendons of the fingers in dactylitis?
Authors: Naredo Esperanza , Largo Raquel , Olivas-Vergara Otto , Herencia Carmen , Mateos-Fernández Myriam , García-de-Pereda-Notario Carlos Miquel , Mérida-Velasco José Ramón , Herrero-Beaumont Gabriel , Murillo-González Jorge
Published: February 2023

Aim: Tenosynovitis is one of the most frequently described inflammatory lesions in psoriatic dactylitis. The aim of the study was to assess by ultrasound the distribution of content within the synovial sheath of the finger flexor tendons in a cadaveric experimental model of tenosynovitis and to describe anatomically the elements of the space between the flexor tendons and the palmar aspect of the proximal phalanx of the fingers.Material and method: Silicone was injected under ultrasound guidance into the digital flexor sheath of the index finger of a hand specimen. Ultrasound images of the distribution of the filling of the flexor synovial space with the injected material were obtained. These images were compared with images from patients with psoriatic dactylitis. The palmar regions of the hand and fingers were dissected to check the distribution of the injected silicone in the synovial cavity. Additionally, we dissected the 2nd to 5th fingers of five cadaveric hands, including the one used for the experiment.Results: During the injection of the substance, we observed an increasing homogeneous hypoechoic band around the flexor tendons that differed from the images of patients. Dissection of the specimen showed the injected silicone distributed throughout the digital flexor sheath to the distal interphalangeal joint. In addition, we provided an illustrated anatomical description of the elements located between the flexor tendons and the palmar aspect of the proximal phalanx, the inflammation of which could simulate flexor tenosynovitis.Conclusion: The observations of this study may contribute to a better understanding of the anatomical structures involved in PsA dactylitis.
Multiparameter estimation of continuous-time quantum walk Hamiltonians through machine learning
Authors: Gianani Ilaria , Benedetti Claudia
Published: February 2023

The characterization of the Hamiltonian parameters defining a quantum walk is of paramount importance when performing a variety of tasks, from quantum communication to computation. When dealing with physical implementations of quantum walks, the parameters themselves may not be directly accessible, and, thus, it is necessary to find alternative estimation strategies exploiting other observables. Here, we perform the multiparameter estimation of the Hamiltonian parameters characterizing a continuous-time quantum walk over a line graph with n-neighbor interactions using a deep neural network model fed with experimental probabilities at a given evolution time. We compare our results with the bounds derived from estimation theory and find that the neural network acts as a nearly optimal estimator both when the estimation of two or three parameters is performed.
Physical Activity Para Report Card for Children and Adolescents With Disabilities in Lithuania
Authors: Pozeriene Jurate , Emeljanovas Arūnas , Ostaseviciene Vida , Skucas Kestutis , Bradauskiene Kristina , Mizeras Renatas , Packeviciute Ausrine , Venckuniene Kristina , Pokvytyte Vaida , Reklaitiene Diana , Ng Kwok
Published: February 2023

Despite the recognized benefits of physical activity (PA) for children and adolescents with disabilities (CAWD), collective information on this is lacking in Lithuania. The purpose of this study was to investigate the current “state of the nation” PA levels of CAWD, based on the 10 indicators from the Active Healthy Kids Global Alliance Global Matrix 4.0 methodology. Scientific articles, practical reports, and published theses related to the 10 indicators from the Global Matrix 4.0 on CAWD age 6–19 years were reviewed, and data were converted to grades from A to F. (A) Strengths, Weaknesses, Opportunities, and Threats analysis was carried out to interpret the grades by four experts. Data on organized sport participation (F), school (D), community & environment (D), and government (C) were available. Data on other indicators are largely missing yet are needed for policymakers and researchers to be aware of the current state of PA among CAWD.
Microscale combinatorial stimulation of human myeloid cells reveals inflammatory priming by viral ligands
Authors: Reyes Miguel , Leff Samantha M. , Gentili Matteo , Hacohen Nir , Blainey Paul C.
Published: February 2023

Cells sense a wide variety of signals and respond by adopting complex transcriptional states. Most single-cell profiling is carried out today at cellular baseline, blind to cells’ potential spectrum of functional responses. Exploring the space of cellular responses experimentally requires access to a large combinatorial perturbation space. Single-cell genomics coupled with multiplexing techniques provide a useful tool for characterizing cell states across several experimental conditions. However, current multiplexing strategies require programmatic handling of many samples in macroscale arrayed formats, precluding their application in large-scale combinatorial analysis. Here, we introduce StimDrop, a method that combines antibody-based cell barcoding with parallel droplet processing to automatically formulate cell population × stimulus combinations in a microfluidic device. We applied StimDrop to profile the effects of 512 sequential stimulation conditions on human dendritic cells. Our results demonstrate that priming with viral ligands potentiates hyperinflammatory responses to a second stimulus, and show transcriptional signatures consistent with this phenomenon in myeloid cells of patients with severe COVID-19.
Single-Ascending-Dose, Food-Effect, and Multiple-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Pangenotypic Anti-Hepatitis C Virus Drug Holybuvir in Healthy Chinese Subjects
Authors: Cao Yuran , Wu Xiaojie , Wang Zhiqiang , Huang Yuxian , Wu Junzhen , Cao Guoying , Yu Jicheng , Wang Jingjing , Yang Haijing , Zhang Wenhong , Zhang Jing
Published: February 2023

Holybuvir is a novel pangenotypic hepatitis C virus NS5B inhibitor. This first in-human study aimed to evaluate the pharmacokinetics (PK), safety, and tolerability of holybuvir and its metabolites and the effect of food on the PK of holybuvir and its metabolites in healthy Chinese subjects.
Evidence of the evolution of the East Antarctic Ice Sheet on the continental slope and rise sedimentary record: Insights from the Sabrina Coast, East Antarctica
Authors: Donda Federica , Romeo Roberto , Leitchenkov German , Gei Davide , Rosenthal Yair , Leventer Amy , Lodolo Emanuele , Noble Taryn L. , Post Alexandra , O’Brien Philip E. , Opdyke Bradley N. , Olivo Elisabetta
Published: February 2023

Deciphering how the Antarctic Ice Sheet has responded to past climate warming is critical to understanding its sensitivity and role in current and future climate change. In this context, knowledge of the evolution of the Antarctic Ice Sheet in catchments with large potential sea-level contributions plays a key role. The Sabrina Coast of East Antarctica lies seaward of the second largest, but least known, subglacial basin on Earth, the Aurora Subglacial Basin. It is part of the East Antarctic Ice Sheet and drains to the Sabrina Coast via the Totten Glacier, the third largest drainage system in East Antarctica. Our refined, comprehensive seismic stratigraphic analysis of a large multichannel seismic data set collected in this sector of the Antarctic margin shows that sediments deposited on the continental slope and rise of the Sabrina Coast retain a well-preserved record of variations in glacial and oceanographic dynamics. Isobath and isopach maps evidence a complex, asymmetric evolution of the Sabrina slope and rise, with the western sector being the main sediment depocenter since the emplacement of the East Antarctic Ice Sheet, as indicated by the up to 4-km-thick glacial-related sequences and inferred sedimentation rates of up to 300 m/m.y. However, significant sediment accumulation also occurs in the eastern area, particularly in the western levees of the canyons. Our findings highlight the potential of this region for deep ocean drilling that will provide an unprecedented history of the dynamics of the marine-based ice sheet in the Aurora Subglacial Basin and its sensitivity to climate change under different background climate conditions.
Supplemental Material: Syntectonic sediment loading and fold-thrust belt structural architecture: An example from the central Appalachians (USA)
Authors: Evans M.A.
Published: February 2023

Table S1: Fluid-inclusion data and estimated overburden.
Incidence of and risk factors for suspected and definitive glaucoma after bilateral congenital cataract surgery: a 5-year follow-up
Authors: Wang Jinghui , Wu Xianghua , Wang Qiwei , Zhou Fengqi , Chen Hui , Chen Wan , Lin Duoru , Zhang Xiayin , Wang Ruixin , Chen Jingjing , Liu Zhenzhen , Lin Zhuoling , Li Xiaoyan , Li Jing , Han Ying , Liu Yizhi , Lin Haotian , Chen Weirong
Published: February 2023

Aims

To report the incidence and associated risk factors for developing suspected and definitive glaucoma after bilateral congenital cataract (CC) removal with a 5-year follow-up.

Methods

Secondary analysis of a prospective longitudinal cohort study. Bilateral CC patients who had undergone cataract surgery between January 2011 and December 2014 at Zhongshan Ophthalmic Centre were recruited. Suspected glaucoma was defined as persistent ocular hypertension requiring medical treatment. Definitive glaucoma was defined as accompanied by the progression of glaucomatous clinical features. According to postoperative lens status in 5 years follow-up: 130 eyes in the aphakia group; 219 in the primary intraocular lens (IOL) implantation group and 337 in the secondary IOL implantation group. The Kaplan-Meier survival and Cox regression analyses were used to explore the cumulative incidence and risk factors for suspected and definitive glaucoma.

Results

Three hundred fifty-one children (686 eyes) with bilateral CCs were enrolled in the study. The mean age at surgery was 1.82±2.08 years, and the mean follow-up duration was 6.26±0.97 years. Suspected and definitive glaucoma developed at a mean time of 2.84±1.75 years (range 0.02–7.33 years) postoperatively. The cumulative incidence of suspected and definitive glaucoma was 9.97% (35 of 351 patients), including 6.12% (42 eyes) for definitive glaucoma and 2.48% (17 eyes) for suspected glaucoma. Microcornea (HR 4.103, p<0.0001), CC family history (HR 3.285, p=0.001) and initial anterior vitrectomy (HR 2.365 p=0.036) were risk factors for suspected and definitive glaucoma. Gender, age at surgery, intraocular surgery frequency, length of follow-up and frequency of neodymium-doped yttrium aluminumaluminium garnet laser were non-statistically significant. Primary IOL implantation was a protective factor (HR 0.378, p=0.007).

Conclusions

Identifying suspected and definitive glaucoma after bilateral CC surgery can lower the risk of secondary blindness in children. Patients with related risk factors need to pay more attention and thus reach early intervention and treatment during clinical practice. Primary IOL implantation may be a potential protective factor, need more clinical trials to be verified.

Trial registration number

NCT04342052.
Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study
Authors: Beyer Georg , Kasprowicz Florian , Hannemann Anke , Aghdassi Ali , Thamm Patrick , Volzke Henry , Lerch Markus M , Kühn Jens-Peter , Mayerle Julia
Published: February 2023

Objective

Changes of the pancreaticobiliary ducts herald disease. Magnetic resonance cholangiopancreatography (MRCP) allows accurate duct visualisation. Data on reliable upper reference ranges are missing.

Design

Cross-sectional whole body MRI data from the population-based Study of Health in Pomerania were analysed. The width of the common bile duct (CBD) and the pancreatic duct (PD) was determined. We aimed to describe the distribution of physiological duct diameters on MRCP in a population of healthy subjects and to identify factors influencing duct size.

Results

After excluding pre-existing pancreaticobiliary conditions, CBD and PD diameters from 938 and 774 healthy individuals, respectively, showed a significant increase with age (p<0.0001) and exceeded the conventional upper reference limit of normal in 10.9% and 18.2%, respectively. Age-dependent upper reference limits of duct diameters were delineated with non-parametric quantile regression, defined as 95th percentile: for CBD up to 8 mm in subjects <65 years and up to 11 mm in subjects ≥65 years. For the PD reference diameters were up to 3 mm in subjects <65 years and up to 4 mm in subjects ≥65 years.

Conclusions

This is the first population-based study delineating age-adjusted upper reference limits of CBD and PD on MRCP. We showed that up to 18.2% of healthy volunteers would have needed diagnostic workup, if the conventional reference values were used. The utilisation of the adapted reference levels may help to avoid unnecessary investigations and thus to reduce healthcare expenditure and test-related adverse events.
Risk of myocardial infarction after invasive outpatient procedures
Authors: Sen Abhijit , Gémes Katalin , Svensen Christer , Varmdal Torunn , Jonsson Magnus , Janszky Imre , Möller Jette
Published: February 2023

Objective

To assess the short-term risk of acute myocardial infarction (AMI) associated with procedures performed at outpatient specialised hospital clinics.

Methods

In this case-crossover, population-based study, we identified first-time AMI cases aged ≥40 years via patient registries and linked them to their surgical intervention in Norway (2008–2016) and Sweden (2001–2014), respectively. The number of individuals with AMI who underwent procedures 0–7 days (hazard period) prior to the AMI diagnosis was compared with cases who were exposed 29–36 days (control period) before the AMI. A total of 6176 patients with AMI who underwent a procedure either during the defined hazard or control period contributed to the analyses. ORs with 95% CIs were computed using conditional logistic regression.

Results

The mean age of the total population was 74.7 years and 64.6% were male. The relative risk was higher following procedures performed under general/regional anaesthesia for gastrointestinal endoscopy (ORsummary, 4.23, 95% CI 1.58 to 11.31), vascular (ORsummary, 3.12, 95% CI 1.10 to 8.90), urological/gynaecological (ORsummary, 2.30, 95% CI 1.50 to 3.53) and orthopaedic (ORsummary,1.78, 95% CI 1.30 to 2.44) procedures, and for ENT (ear, nose and throat) and mouth procedures (ORsummary,1.53, 95% CI 1.19 to 1.99) performed under local anaesthesia.

Conclusion

This large population-based register study from two countries suggests that outpatient procedures are generally safe with regard to the postoperative risk of AMI. However, some procedures, such as gastrointestinal endoscopy, vascular procedures and urological/gynaecological procedures may increase the risk of AMI by twofold or threefold within the first 8 days after the procedures. Further studies are warranted to assess whether the effect is modified by cardiovascular medication or other clinical factors.
Predictive value of the TRI-SCORE for in-hospital mortality after redo isolated tricuspid valve surgery
Authors: Dreyfus Julien , Bohbot Yohann , Coisne Augustin , Lavie-Badie Yoan , Flagiello Michele , Bazire Baptiste , Eggenspieler Florian , Viau Florence , Riant Elisabeth , Mbaki Yannick , Eyharts Damien , Sénage Thomas , Modine Thomas , Nicol Martin , Doguet Fabien , Le Tourneau Thierry , Tribouilloy Christophe , Donal Erwan , Tomasi Jacques , Habib Gilbert , Selton-Suty Christine , Radu Costin , Lim Pascal , Raffoul Richard , Iung Bernard , Obadia Jean-Francois , Audureau Etienne , Messika-Zeitoun David
Published: February 2023

Objectives

The TRI-SCORE reliably predicts in-hospital mortality after isolated tricuspid valve surgery (ITVS) on native valve but has not been tested in the setting of redo interventions. We aimed to evaluate the predictive value of the TRI-SCORE for in-hospital mortality in patients with redo ITVS and to compare its accuracy with conventional surgical risk scores.

Methods

Using a mandatory administrative database, we identified all consecutive adult patients who underwent a redo ITVS at 12 French tertiary centres between 2007 and 2017. Baseline characteristics and outcomes were collected from chart review and surgical scores were calculated.

Results

We identified 70 patients who underwent a redo ITVS (54±15 years, 63% female). Prior intervention was a tricuspid valve repair in 51% and a replacement in 49%, and was combined with another surgery in 41%. A tricuspid valve replacement was performed in all patients for the redo surgery. Overall, in-hospital mortality and major postoperative complication rates were 10% and 34%, respectively. The TRI-SCORE was the only surgical risk score associated with in-hospital mortality (p=0.005). The area under the receiver operating characteristic curve for the TRI-SCORE was 0.83, much higher than for the logistic EuroSCORE (0.58) or EuroSCORE II (0.61). The TRI-SCORE was also associated with major postoperative complication rates and survival free of readmissions for heart failure.

Conclusion

Redo ITVS was rarely performed and was associated with an overall high in-hospital mortality and morbidity, but hiding important individual disparities. The TRI-SCORE accurately predicted in-hospital mortality after redo ITVS and may guide clinical decision-making process (www.tri-score.com).
From alchemy to personalised medicine: the journey of laboratory medicine
Authors: Verna Roberto
Published: February 2023

This review summarises the long period in which man has approached nature to understand its powers, and has tried to control it through physical and chemical, and also magical, practices. From the attempt to manage nature to the development of primordial drugs and medical practices and later to achieve modern biomedical science, laboratory practices always played a pivotal role. Over the years and centuries, the laboratory has acquired more and more importance in the improvement of health.

In addition to the well-known importance of laboratory medicine in the early diagnosis and appropriateness, the discoveries of the last 50 years have also given the Laboratory a decisive role in regenerative and personalised medicine.

This paper examines the evolution of the laboratory and is not meant to be a treatise on the history of medicine. The goal is to highlight the moments of the transition from magic and alchemy to laboratory science.

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Roberto Verna is President of the World Association of Societies of Pathology and Laboratory Medicine and President of the Academy for Health and Clinical Research.
Occupational risk factors associated with lower urinary tract symptoms among female workers: a systematic review
Authors: Yoo Hyoungseob , Kim Jae Yoon , Lee Yu Min , Kang Mo-Yeol
Published: February 2023

A systematic review was performed aiming to identify the various occupational risk factors of lower urinary tract symptoms (LUTS) among female workers. A systematic, comprehensive literature search of PubMed, Embase and Cochrane Library databases was conducted to identify studies published until 24 November 2021, evaluating the possible occupational risk factors of LUTS among female workers. Two reviewers assessed all articles retrieved through a computerised search for eligibility using predetermined criteria. Data on the first author, publication year, country, study design, participants, identified occupational risk factors, outcome variables and main results were extracted from the selected articles. The Newcastle–Ottawa Quality Assessment Scale guidelines were adopted to estimate the quality scores. Overall, our search yielded a total of 16 articles suitable for review. The occupational risk factors identified in the studies were strenuous physical demand and activity, prolonged sitting, occupational stress, shift work, limited use of the toilet at work and other occupational environments (eg, an unclean and uncomfortable workplace, dangerous job and probability of accidents, feeling pressed for time and awkward position for long periods). The findings of this review may raise awareness regarding the risk of LUTS among female workers with these factors. From an occupational health perspective, the implementation of tailored prevention strategies based on these occupational factors may prevent female workers from developing LUTS.

PROSPERO registration number

CRD42022316728.
Universal, selective and indicated interventions for supporting mental health at the workplace: an umbrella review of meta-analyses
Authors: Miguel Clara , Amarnath Arpana , Akhtar Aemal , Malik Aiysha , Baranyi Gergő , Barbui Corrado , Karyotaki Eirini , Cuijpers Pim
Published: February 2023

The current umbrella review aimed to assess and summarise evidence on universal, selective and indicated interventions for mental health at the workplace. This umbrella review forms one of the evidence reviews which were commissioned by the WHO to develop global guidelines on mental health at work. We conducted systematic searches in five bibliographic databases (PubMed, Embase, PsycINFO, Cochrane and Global Medicus Index) and included meta-analyses of randomised trials examining psychosocial, physical activity and lifestyle interventions delivered to all general workers (universal interventions), at-risk workers (selective interventions) and workers already experiencing symptoms of mental disorders (indicated interventions). We included outcomes from seven domains: symptoms of mental health conditions, positive mental health, quality of life, work-related outcomes, substance use, suicide-related outcomes and potential adverse effects. We identified 16 meta-analyses producing 66 pooled effect sizes of the examined interventions, mostly on symptoms of mental health conditions (n=43 pooled effect sizes) (eg, burnout, insomnia, stress) and positive mental health (n=15) (eg, well-being). Most of the evidence on universal, selective and indicated interventions was focused on psychosocial interventions, showing small to moderate effects across the various outcomes. Certainty levels according to GRADE (Grading of Recommendations Assessment, Development and Evaluation) were low to very low in almost all of the examined outcomes. The results of existing meta-analyses are promising for the use of preventative and early treatment interventions in the workplace. However, the quality and certainty of the evidence were very modest, and further research on the effectiveness of these interventions is warranted.
Postharvest handling and vase life of cut sunflower
Authors: Kalinowski Jennifer , Moody Erin P. , Dole John M.
Published: February 2023

The sunflower ( Helianthus annuus L.) is a commercially important cut flower requiring research into postharvest factors such as recutting, water uptake, stem number, cooling rate, and storage temperature to maximize vase life. Stems of 'Sunbright' sunflowers were either recut before or after a drying period up to 48 h. Water uptake, stem quality, and microbial counts were determined 4 days after rehydration. Water potential was determined on five corresponding leaves per treatment. The effects of stem number per vase were evaluated with either 1, 3, 5, or 10 stems. Effects of cooling rate were determined by temperatures of 5 °C for 3 days in the dark, 5 °C for 2 days in the dark preceded by 24 h at either 20 °C with light or 32 °C in a shaded area outdoors, or were maintained in a shaded area at 32 °C for 3 days. Hydration and storage temperature effects were determined by either transferring to a postharvest environment, 20 °C cooler for 2 h, immediate storage for 2 days at 5 °C, or 3 days at 5 °C after recutting the basal stem. Allowing stems to dry up to 48 h reduced vase life by 2.3 days or less. Vase life was unaffected by harvesting into water or by the number of stems in a vase but was affected by temperature such that the longest vase life of 13.2 days occurred when stems were stored for 3 days at 5 ± 0.5 °C followed by postharvest evaluation at 20 ± 1 °C.
Neutron capture cross section of $$^{83}$$Kr
Authors: Fiebiger Stefan , Baramsai Bayarbadrakh , Couture Aaron , Krtička Milan , Mosby Shea , O’Donnell John , Reifarth René , Rusev Gencho , Ullmann John , Weigand Mario , Wolf Clemens
Published: February 2023

The neutron capture cross section of $$^{83}$$

83

Kr has been measured via the time-of-flight technique between 25 meV and 500 keV. The experiment used the DANCE array at the Los Alamos National Laboratory. Maxwellian Averaged Cross Sections have been derived for a range of stellar temperatures and are found to be in good agreement with previous data. The impact of the new cross sections on stellar nucleosynthesis has been investigated.
Accelerator techniques and nuclear data needs for ion beam analysis of wall materials in controlled fusion devices
Authors: Rubel Marek , Primetzhofer Daniel , Petersson Per , Charisopoulos Sotirios , Widdowson Anna
Published: February 2023

A brief overview of ion beam analysis methods and procedures in studies of materials exposed to fusion plasmas in controlled fusion devices with magnetic confinement is presented. The role of accelerator techniques in the examination and testing of materials for fusion applications is emphasised. Quantitative results are based on robust nuclear data sets, i.e. stopping powers and reaction cross-sections. Therefore, the work has three major strands: (i) assessment of fuel inventory and modification of wall materials by erosion and deposition processes; (ii) equipment development to perform cutting-edge research; (iii) determination of nuclear data for selected ion-target combinations. Advantages and limitations of methods are addressed. A note is also given on research facilities with capabilities of handling radioactive and beryllium-contaminated materials.
MHD Marangoni convection heat transfer of Ag-Cu hybrid nanofluid under a stretching/shrinking sheet with the effect of suction
Authors: Jaafar A’isyah , Jamaludin Anuar , Nazar Roslinda , Pop Ioan
Published: February 2023

This paper examines the heat transfer characteristics of magnetohydrodynamics (MHD), suction, and Marangoni convection under the stretching/shrinking Ag–Cu hybrid nanofluid surface flow. First, the governing partial differential equations (PDEs) were transformed into ordinary differential equations (ODEs), and the numerical result was obtained using the boundary value problem solver (bvp4c) in MATLAB. The development of the Nusselt number, the velocity profile and the temperature profile was plotted, discussed and inspected. Next, this paper undergoes stability analysis and heat transfer rate comparison between water, nanofluid and hybrid nanofluid. The dual solutions were observed, and the upper branch solution is determined to be stable. Compared to water, the heat transfer rates of Ag–Cu hybrid nanofluid and Cu nanofluid were accelerated by 2.84% and 2.75%, respectively.
Computational study of blood hemodynamic in ICA aneurysm with coiling embolism
Authors: Mirzaei Poueinak Milad , Abdollahi Seyyed Amirreza , Alizadeh As’ad , Youshanlui Mahya Ahmadpour , Zekri Hussein , Gerdroodbary M. Barzegar
Published: February 2023

The importance of the blood flow feature on the hemorrhage of the cerebral aneurysm is confirmed by surgeons and scientists. In this paper, the effects of blood hemodynamics on the growth and rupture of the Internal Carotid Intracranial (ICA) are fully investigated. This study tries to demonstrate the blood feature inside the ICA at different time stages. Besides, the effect of coiling on blood characteristics is extensively studied in this research. Computational Fluid dynamic (CFD) is used for the analysis of the blood hemodynamics on the wall shear stress and pressure distribution within the aneurysm. Obtained results indicate that reducing the coiling porosity from 0.89 to 0.79 declines maximum WSS by about 26% and 61% for [Formula: see text] and 0.45, respectively, at the peak systolic stage. Our findings show that decreasing the porosity (or increasing coiling fraction) would decrease the maximum OSI by more than 55% in high blood viscosity of [Formula: see text].
Research Progress of Traditional Chinese Medicine Monomers in Reversing Multidrug Resistance of Breast Cancer
Authors: Wang Shuya , Yang Shuangyu , Yang Xiaojia , Deng Dan , Li Jie , Dong Mingqing
Published: February 2023

Breast cancer is a malignant disease with an increasing incidence. Chemotherapy is still an important means for breast cancer treatment, but multidrug resistance (MDR) greatly limits its clinical application. Therefore, the high-efficiency MDR reversal agents are urgently needed. Traditional Chinese medicine (TCM) monomers have unique advantages in reversing chemotherapeutic MDR because of its low toxicity, high efficiency, and ability to impact multiple targets. This review firstly summarizes the major mechanisms of MDR in breast cancer, including the reduced accumulation of intracellular chemotherapeutic drugs, the promoted inactivation of intracellular chemotherapeutic drugs, and the enhanced damage repair ability of DNA, etc., and secondly highlights the research progress of 15 kinds of TCM monomers, including curcumin, resveratrol, emodin, apigenin, tetrandrine, gambogic acid, matrine, paeonol, schisandrin B, [Formula: see text]-elemene, astragaloside IV, berberine, puerarin, tanshinone IIA, and quercetin, in reversing MDR of breast cancer. This review also provides the suggestion for the future research of MDR reversal agents in breast cancer.
Quercetin Inhibits Intrahepatic Cholangiocarcinoma by Inducing Ferroptosis and Inhibiting Invasion via the NF-κB Pathway
Authors: Song Yinghui , Zhang Zhihua , Chai Qin , Zheng He , Qi Yuchen , Xia Guoyi , Yu Zhangtao , Yang Ranzhiqiang , Huang Junkai , Li Yuhang , Peng Chuang , Jiang Bo , Liu Sulai
Published: February 2023

Intrahepatic cholangiocarcinoma (ICC) is a rare, highly fatal hepatobiliary malignancy, with very limited treatment options and, consequently, a poor prognosis. Recently, emerging evidence has suggested the potential of quercetin (QE) for use in cancer therapy. The purpose of this study is to investigate whether QE could inhibit ICC. The effects of QE on the proliferation, apoptosis, and invasion of ICC were analyzed in vitro. The inhibitory effect of QE on ICC was also verified in vivo. The RNA sequence was applied to explore the mechanism of QE. Functional verification was also performed after RNA sequencing using activators and inhibitors of nuclear factor-kappa-B (NF-[Formula: see text]B) and ferroptosis. The results showed that QE could inhibit the proliferation and survival of ICC cells, induce the arrest of ICC cells in the G1 phase, promote the apoptosis of ICC cells, and inhibit the invasion of ICC cells. Furthermore, QE could promote ferroptosis in ICC cells by inhibiting the NF-[Formula: see text]B pathway. In conclusion, QE is a new ferroptosis inducer and NF-[Formula: see text]B inhibitor that can not only induce ferroptosis, but also inhibit the invasion of ICC cells, providing a prospective strategy for the treatment of ICC.
CAN CONSUMER CREDIT STIMULATE CONSUMER CONFIDENCE? EVIDENCE FROM THE TIME-VARYING ASPECT
Authors: SU CHI-WEI , PECULEA ADELINA DUMITRESCU , WANG KAI-HUA
Published: February 2023

This study discusses the nexus between consumer credit (CC) and consumer confidence (CF) in the case of China with a bootstrap rolling-window causality test. The new empirical results demonstrate that CC improves CF in specific periods by loosening liquidity constraints and increasing consumer power temporarily. Meanwhile, a negative link is also found, which can be explained by policy adjustment and financial instabilities. On the contrary, CF negatively influences CC in some periods, reflecting consumers’ attitudes toward the future would change borrowing behaviors. But this relationship would be disrupted by government intervention and public events such as the COVID-19 pandemic. The contribution is that time-varying, multiple-directional and dynamic causalities are captured, which enriches the theoretical framework between CC and CF. Therefore, the government must design and adjust loaning policies against specific circumstances and transmit positive signs to consumers. Future study needs to pay attention to different types of CC and try to reveal their heterogeneous influences on CF. In addition, the effect evaluation for CC policy is also another focus in the next research.
Numerical investigations of stochastic Newell–Whitehead–Segel equation in (2+1) dimensions
Authors: Ahmed Nauman , Yasin Muhammad Waqas , Iqbal Muhammad Sajid , Akgül Ali , Rafiq Muhammad , Raza Ali , Baber Muhammad Zafarullah
Published: February 2023

The stochastic Newell–Whitehead–Segel in [Formula: see text] dimensions is under consideration. It represents the population density or dimensionless temperature and it discusses how stripes appear in temporal and spatial dimensional systems. The Newell–Whitehead–Segel equation (NWSE) has applications in different areas such as ecology, chemical, mechanical, biology and bio-engineering. The important thing is if we see the problem in the two-dimensional (2D) manifold, then the whole 3D picture can be included in the model. The 3D space is embedded compactly in the 2D manifolds. So, 2D problems for the Newell–White–Segel equation are very important because they consider the one, two and three dimensions in it. The numerical solutions of the underlying model have been extracted successfully by two schemes, namely stochastic forward Euler (SFE) and the proposed stochastic nonstandard finite difference (SNSFD) schemes. The existence of the solution is guaranteed by using the contraction mapping principle and Schauder’s fixed-point theorem. The consistency of each scheme is proved in the mean square sense. The stability of the schemes is shown by using von Neumann criteria. The SFE scheme is conditionally stable and the SNSFD scheme is unconditionally stable. The efficacy of the proposed methods is depicted through the simulations. The 2D and 3D graphs are plotted for various values of the parameters.
Composite phosphor of a self-organized silica mixed YAG:Ce
Authors: Oishi Masatsugu , Ohta Yuya , Sogabe Tatsuki , Moriga Toshihiro , Shih Shao-Ju
Published: February 2023

Composite powders mixed with yttrium aluminum garnet (YAG:Ce) and SiO2 powders were prepared in a tetraethyl orthosilicate solution of an alkali hydrolysis bath. The state of the composite powders varies depending on the reaction conditions: the amount of ammonium water and the reaction time. The photoluminescence property of the composite powder was the same as that of pure YAG powder, while the quantum efficiency varied depending on the morphologies of the composite powders. The quantum efficiency improved for the composite powder with nano-sized silica particles covering the YAG surface.
A Cross Entropy-Based Approach to Controller Placement Problem with Link Failures in SDN
Authors: Yin Hanmin , Chen Jue
Published: February 2023

The Controller Placement Problem (CPP) is a key research topic in Software Defined Network (SDN), as the communication delay is influenced by the position of controllers and switches. On that basis, the network failures may happen occasionally, which can cause the increase of propagation latency and the reduction of network performance. As a result, it is essential to research the Controller Placement problem for Link Failures (CPLF). In this paper, authors propose a method based on the cross entropy to solve CPP after link failures, and adopt the Halton sequence to reduce the computation overhead of simulating link failures while guaranteeing the accuracy. In the experiments, we measure and compare the worst-case delay among three methods: our proposed cross entropy-based controller placement algorithm, the optimized controller placement algorithm and a greedy-based controller placement algorithm, and conduct experiments on six real network topologies. The experimental results verify that our proposed method can reduce the worst-case delay by [Formula: see text] in comparison with GPA. Moreover, the proposed method can always find optimized controller placement schemes no matter how the network scale or the number of controller varies, with a less than [Formula: see text] error when compared with the optimal solution.
Influence of resonances on the 11B(n, γ)12B reaction rate. Capture to the excited states of 12B
Authors: Dubovichenko S. B. , Burkova N. A. , Tkachenko A. S. , Dzhazairov-Kakhramanov A. V.
Published: February 2023

Based on the framework of the modified potential cluster model (MPCM), with orbital states classified using Young diagrams, we consider the possibility of prediction absentee of experimental data for the total cross-sections of the radiative neutron capture on [Formula: see text]B to the first excited state of [Formula: see text]B at 0.95314[Formula: see text]MeV (2[Formula: see text]), to the second excited state of [Formula: see text]B at 1.67365[Formula: see text]MeV (2−), and prediction absentee of experimental data for the total cross-sections to the third and fourth excited states of [Formula: see text]B at 2.6208[Formula: see text]MeV (1−) and 2.723[Formula: see text]MeV (0[Formula: see text]), for a reaction energy of 10[Formula: see text]meV to 7[Formula: see text]MeV. We calculate the reaction rate for a temperature range of 0.01–10.0 [Formula: see text] on the basis of the obtained cross-sections, which take into account resonances up to 5[Formula: see text]MeV. We then demonstrate that low-lying resonances have a significant impact on the reaction rate of capture. An approximation for the calculated reaction rate is derived based on an analytical formula.
VARIATIONAL PERSPECTIVE TO FRACTAL KAWAHARA MODEL IN MICROGRAVITY SPACE
Authors: YAO SHAO WEN
Published: February 2023

In this study, we present the idea of variational fractal transform method to find the analytical solution for the fractal Kawahara equation that arises in shallow water waves in the microgravity space or with the unsmooth boundary. The fractal semi-inverse method is used to establish a fractal variational formulation of the problem, which provides the analysis of the soliton solution and its physical properties. An example is considered to show that this new scheme is straightforward and efficient, and can be generalized to other nonlinear evolution equations with fractal derivatives performance.