bluuebunny/crossref_metadata_2025 huggingface dataset:
Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition
Authors: Thorpe Chavaunne T. , Peffers Mandy J. , Simpson Deborah , Halliwell Elizabeth , Screen Hazel R. C. , Clegg Peter D.
Published: February 2016

Tendon is a simple aligned fibre composite, consisting of collagen-rich fascicles surrounded by a softer interfascicular matrix (IFM). The composition and interactions between these material phases are fundamental in ensuring tissue mechanics meet functional requirements. However the IFM is poorly defined, therefore tendon structure-function relationships are incompletely understood. We hypothesised that the IFM has a more complex proteome, with faster turnover than the fascicular matrix (FM). Using laser-capture microdissection and mass spectrometry, we demonstrate that the IFM contains more proteins and that many proteins show differential abundance between matrix phases. The IFM contained more protein fragments (neopeptides), indicating greater matrix degradation in this compartment, which may act to maintain healthy tendon structure. Protein abundance did not alter with ageing, but neopeptide numbers decreased in the aged IFM, indicating decreased turnover which may contribute to age-related tendon injury. These data provide important insights into how differences in tendon composition and turnover contribute to tendon structure-function relationships and the effects of ageing.
Zebrafish as a Model to Investigate Dynamin 2-Related Diseases
Authors: Bragato Cinzia , Gaudenzi Germano , Blasevich Flavia , Pavesi Giulio , Maggi Lorenzo , Giunta Michele , Cotelli Franco , Mora Marina
Published: February 2016

Mutations in the dynamin-2 gene (DNM2) cause autosomal dominant centronuclear myopathy (CNM) and dominant intermediate Charcot-Marie-Tooth (CMT) neuropathy type B (CMTDIB). As the relation between these DNM2-related diseases is poorly understood, we used zebrafish to investigate the effects of two different DNM2 mutations. First we identified a new alternatively spliced zebrafish dynamin-2a mRNA (dnm2a-v2) with greater similarity to human DNM2 than the deposited sequence. Then we knocked-down the zebrafish dnm2a, producing defects in muscle morphology. Finally, we expressed two mutated DNM2 mRNA by injecting zebrafish embryos with human mRNAs carrying the R522H mutation, causing CNM, or the G537C mutation, causing CMT. Defects arose especially in secondary motor neuron formation, with incorrect branching in embryos injected with CNM-mutated mRNA and total absence of branching in those injected with CMT-mutated mRNA. Muscle morphology in embryos injected with CMT-mutated mRNA appeared less regularly organized than in those injected with CNM-mutated mRNA. Our results showing, a continuum between CNM and CMTDIB phenotypes in zebrafish, similarly to the human conditions, confirm this animal model to be a powerful tool to investigate mutations of DNM2 in vivo.
Creep turns linear in narrow ferromagnetic nanostrips
Authors: Leliaert Jonathan , Van de Wiele Ben , Vansteenkiste Arne , Laurson Lasse , Durin Gianfranco , Dupré Luc , Van Waeyenberge Bartel
Published: February 2016

The motion of domain walls in magnetic materials is a typical example of a creep process, usually characterised by a stretched exponential velocity-force relation. By performing large-scale micromagnetic simulations and analyzing an extended 1D model which takes the effects of finite temperatures and material defects into account, we show that this creep scaling law breaks down in sufficiently narrow ferromagnetic strips. Our analysis of current-driven transverse domain wall motion in disordered Permalloy nanostrips reveals instead a creep regime with a linear dependence of the domain wall velocity on the applied field or current density. This originates from the essentially point-like nature of domain walls moving in narrow, line- like disordered nanostrips. An analogous linear relation is found also by analyzing existing experimental data on field-driven domain wall motion in perpendicularly magnetised media.
Exact quantum Bayesian rule for qubit measurements in circuit QED
Authors: Feng Wei , Liang Pengfei , Qin Lupei , Li Xin-Qi
Published: February 2016

Developing efficient framework for quantum measurements is of essential importance to quantum science and technology. In this work, for the important superconducting circuit-QED setup, we present a rigorous and analytic solution for the effective quantum trajectory equation (QTE) after polaron transformation and converted to the form of Stratonovich calculus. We find that the solution is a generalization of the elegant quantum Bayesian approach developed in arXiv:1111.4016 by Korotokov and currently applied to circuit-QED measurements. The new result improves both the diagonal and off-diagonal elements of the qubit density matrix, via amending the distribution probabilities of the output currents and several important phase factors. Compared to numerical integration of the QTE, the resultant quantum Bayesian rule promises higher efficiency to update the measured state and allows more efficient and analytical studies for some interesting problems such as quantum weak values, past quantum state and quantum state smoothing. The method of this work opens also a new way to obtain quantum Bayesian formulas for other systems and in more complicated cases.
High production of CH4 and H2 by reducing PET waste water using a non-diaphragm-based electrochemical method
Authors: Kim Nam-Gyu , Yim Kwang-Jin , Kim Chan-Soo , Song Dong-Keun , Okuyama Kikuo , Han Min-ho , Kim Young-hoo , Lee Sung-Eun , Kim Tae-Oh
Published: February 2016

In recent years, the worldwide use of polyethylene terephthalate (PET) has increased exponentially. PET wastewater contains ethylene glycol (EG) and terephthalic acid (TPA). In this study, we present a unique method for producing combustible gases like CH4and H2from PET wastewater by electrochemical reaction of EG and TPA. The non-diaphragm-based electrochemical (NDE) method was used to treat PET wastewater. The electrochemical removal of EG and TPA from PET wastewater was examined and the optimal conditions for their reduction to CH4and H2were determined. Using the proposed system, 99.9% of the EG and TPA present in the PET wastewater samples were degraded to produce CH4and H2, at applied voltages lower than 5 V. The highest Faradaic efficiency achieved for EG and TPA reduction was 62.2% (CH4, 25.6%; H2, 36.6%), at an applied voltage of 0.8 V. Remarkably, CH4was produced from EG decomposition and H2from TPA decomposition. To the best of our knowledge, this is the first reported instance of CH4and H2production from EG and TPA, respectively. The electrochemical reductive treatment will be an important discovery for reducing water contamination and replacing fossil fuels with respect to generating green energy.
Hybrid magnetoresistance in Pt-based multilayers: Effect originated from strong interfacial spin-orbit coupling
Authors: Meng Kangkang , Xiao Jiaxing , Wu Yong , Miao Jun , Xu Xiaoguang , Zhao Jianhua , Jiang Yong
Published: February 2016

The hybrid magnetoresistance (MR) behaviors in Pt/Co90Fe10/Pt, Mn1.5Ga/Pt and Mn1.5Ga/Pt/Co90Fe10/Pt multilayers have been investigated. Both planer Hall effect (PHE) and angle-dependent MR in Pt/Co90Fe10/Pt revealed the combination of spin Hall MR (SMR) and normal anisotropic MR (AMR), indicating the large contribution of strong spin-orbit coupling (SOC) at the interfaces. When Pt contacted with perpendicular magnetic anisotropy (PMA) metal Mn1.5Ga, the strong interfacial SOC modified the effective anomalous Hall effect. The MR in Mn1.5Ga/Pt/Co90Fe10/Pt is not a simple combination of SMR and AMR, but ascribed to the complicated domain wall scattering and strong interfacial SOC when Pt is sandwiched by the in-plane magnetized Co90Fe10 and the PMA Mn1.5Ga.
Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury
Authors: Wu Deqing , Zeng Yue , Fan Yuting , Wu Jianghong , Mulatibieke Tunike , Ni Jianbo , Yu Ge , Wan Rong , Wang Xingpeng , Hu Guoyong
Published: February 2016

Junctional adhesion molecule-C (JAM-C) plays a key role in the promotion of the reverse transendothelial migration (rTEM) of neutrophils, which contributes to the dissemination of systemic inflammation and to secondary organ damage. During acute pancreatitis (AP), systemic inflammatory responses lead to distant organ damage and typically result in acute lung injury (ALI). Here, we investigated the role of rTEM neutrophils in AP-associated ALI and the molecular mechanisms by which JAM-C regulates neutrophil rTEM in this disorder. In this study, rTEM neutrophils were identified in the peripheral blood both in murine model of AP and human patients with AP, which elevated with increased severity of lung injury. Pancreatic JAM-C was downregulated during murine experimental pancreatitis, whose expression levels were inversely correlated with both increased neutrophil rTEM and severity of lung injury. Knockout of JAM-C resulted in more severe lung injury and systemic inflammation. Significantly greater numbers of rTEM neutrophils were present both in the circulation and pulmonary vascular washout in JAM-C knockout mice with AP. This study demonstrates that during AP, neutrophils that are recruited to the pancreas may migrate back into the circulation and then contribute to ALI. JAM-C downregulation may contribute to AP-associated ALI via promoting neutrophil rTEM.
Core–shell Fructus Broussonetia-like Au@Ag@Pt nanoparticles as highly efficient peroxidase mimetics for supersensitive resonance-enhanced Raman sensing
Authors: Li Junrong , Lv Liang , Zhang Guannan , Zhou Xiaodong , Shen Aiguo , Hu Jiming
Published: February 2016

Synthesis of core–shell Fructus Broussonetia-like Au@Ag@Pt nanoparticles via galvanic replacement and reagent reduction.
A fluorescence-based assay for T4 polynucleotide kinase/phosphatase activity based on a terminal transferase-aided photoinduced electron transfer strategy
Authors: Ma Changbei , Jin Shunxin , Wang Jun , Wang Kemin , Liu Haisheng , Wu Kefeng
Published: February 2016

A novel fluorescence method for detection of T4 polynucleotide kinase/phosphatase activity based on a terminal transferase-aided photoinduced electron transfer strategy.
A trace analysis method based on HPLC-MS/MS for the simultaneous determination of residues of the two isomers of pyrisoxazole in tomato fruit and soil
Authors: Zhu He , Jia Fuyan , Ding Qi , Huang Chengtian , Yu Yang , Wang Yuan , Xu Weichang , Ji Mingshan
Published: February 2016

A simple, sensitive and accurate method for the simultaneous determination of residues of the two isomers of pyrisoxazole in tomato fruit and soil was established using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).
Total synthesis of laidlomycin
Authors: Lee Wonchul , Kang Sungkyoung , Jung Byunghyuck , Lee Hee-Seung , Kang Sung Ho
Published: February 2016

The synthesis of laidlomycin is described.
Synthesis and spectral measurements of sulphonated graphene: some anomalous observations
Authors: Maiti Susmita , Kundu Somashree , Ghosh Debasmita , Mondal Somrita , Roy Chandra Nath , Saha Abhijit
Published: February 2016

The present report demonstrates how a sulphonation process, a key route for synthesizing water soluble graphene, can influence the optical behavior of precursor graphene oxide, intermediate reaction products and sulphonated graphene.
Perovskite-structured AMnxB1−xO3 (A = Ca or Ba; B = Fe or Ni) redox catalysts for partial oxidation of methane
Authors: Mishra Amit , Galinsky Nathan , He Feng , Santiso Erik E. , Li Fanxing
Published: February 2016

High oxygen carrying capacity, lack of loosely bound lattice oxygen, and preferential surface segregation of Ba make BaMnxB1−xO3 (B = Ni or Fe) based redox catalysts suitable for chemical looping reforming of methane with high syngas yield and coke resistance.
Plant polyphenols alter a pathway of energy metabolism by inhibiting fecal Bacteroidetes and Firmicutes in vitro
Authors: Xue Bin , Xie Jinli , Huang Jiachen , Chen Long , Gao Lijuan , Ou Shiyi , Wang Yong , Peng Xichun
Published: February 2016

This study investigated the effect of plant polyphenols on faecal microbiota metabolizing oligosaccharides. The results show that plant polyphenols can change the pathway of degrading FOS or even energy metabolism in vivo by altering gut microbiota composition.
Sc20C60: a volleyballene
Authors: Wang Jing , Ma Hong-Man , Liu Ying
Published: February 2016

A stable volleyball-like molecular cluster,VolleyballeneSc20C60, was identified. It possesses relatively high symmetry and a hollow space that can be used to accommodate other atoms or molecules for the purpose of studying fundamental chemistry.
Fabrication and optical enhancing properties of discrete supercrystals
Authors: Tebbe Moritz , Lentz Sarah , Guerrini Luca , Fery Andreas , Alvarez-Puebla Ramon A. , Pazos-Perez Nicolas
Published: February 2016

Discrete gold nanoparticle crystals with tunable size and morphology are fabricatedviaa fast and inexpensive template-assisted method.
Simple assembly of polysubstituted pyrazoles and isoxazoles via ring closure–ring opening domino reaction of 3-acyl-4,5-dihydrofurans with hydrazines and hydroxylamine
Authors: Chagarovskiy Alexey O. , Budynina Ekaterina M. , Ivanova Olga A. , Rybakov Victor B. , Trushkov Igor V. , Melnikov Mikhail Ya.
Published: February 2016

A general approach to 2-(pyrazolyl-/isoxazolyl-)ethanols based on the Brønsted acid-initiated reaction of 3-acyl-4,5-dihydrofurans with hydrazines or hydroxylamine was developed.
Six- and seven-coordinate Fe(ii) and Zn(ii) compounds ligated by unsymmetric xanthene-based ligands: characterization and magnetic properties
Authors: Haas Ruth M. , Arshad Muhammad , Anthony James , Altmann Philipp J. , Pöthig Alexander , Köhler Frank H. , Hess Corinna R.
Published: February 2016

We present new ligand platforms for pentagonal bipyramidal metal complexes, and the characterization of the corresponding Zn(ii)- and Fe(ii)-containing compounds.
Following Ramachandran: exit vector plots (EVP) as a tool to navigate chemical space covered by 3D bifunctional scaffolds. The case of cycloalkanes
Authors: Grygorenko Oleksandr O. , Babenko Pavlo , Volochnyuk Dmitry M. , Raievskyi Oleksii , Komarov Igor V.
Published: February 2016

An approach to analysis and visualization of chemical space covered by disubstituted scaffolds, which is based on exit vector plots (EVP), is used for analysis of cycloalkane. Four clearly defined regions (α, β, γ and δ) are found in their EVP.
Preventive effect of carob (Ceratonia siliqua L.) in dextran sulfate sodium-induced ulcerative colitis in rat
Authors: Rtibi Kaïs , Jabri Mohamed-Amine , Selmi Slimen , Sebai Hichem , Marie Jean-Claude , Amri Mohamed , Marzouki Lamjed , El-Benna Jamel
Published: February 2016

Inflammation and oxidative stress are a common mechanism of many gastrointestinal diseases such ulcerative colitis.
Enhanced microwave absorption properties of ferroferric oxide/graphene composites with a controllable microstructure
Authors: Zhang Rui , Huang Xiaoxiao , Zhong Bo , Xia Long , Wen Guangwu , Zhou Yu
Published: February 2016

With experimentally controlled structures from ring-like, flower-like to solid spheres for nanoparticles, the Fe3O4/graphene composites show excellent microwave absorption properties.
A targeted agent with intercalation structure for cancer near-infrared imaging and photothermal therapy
Authors: Li Chunyang , Liang Ruizheng , Tian Rui , Guan Shanyue , Yan Dongpeng , Luo Jiaoyang , Wei Min , Evans David G. , Duan Xue
Published: February 2016

A new targeted photothermal agent is synthesized by co-intercalation of indocyanine green (ICG) and folic acid (FA) into the layered double hydroxide (LDH), which can be potentially used in cancer NIR imaging and photothermal therapy (PTT) field.
One-pot synthesis of graphene/zinc oxide by microwave irradiation with enhanced supercapacitor performance
Authors: Guo Yanzhen , Chang Binbin , Wen Ting , Zhao Chunmei , Yin Hang , Zhou Yannan , Wang Yonggang , Yang Baocheng , Zhang Shouren
Published: February 2016

A facile one-step microwave irradiation method is developed to synthesize a composite of graphene and zinc oxide, which is quick and environmentally friendly.
A monolithic three-dimensional macroporous graphene anode with low cost for high performance microbial fuel cells
Authors: Huang Lihua , Li Xiufen , Ren Yueping , Wang Xinhua
Published: February 2016

Monolithic 3D-G which is inflexible and has a macroporous structure, crumpled matrix, good conductivity and low cost enhanced the electrogenesis of a MFC.
Insights into the deactivation mechanism of metal carbide catalysts for dry reforming of methane via comparison of nickel-modified molybdenum and tungsten carbides
Authors: Yao Zhiwei , Jiang Jun , Zhao Yu , Luan Fubing , Zhu Jiang , Shi Yan , Gao Haifeng , Wang Haiyan
Published: February 2016

The Ni–WC catalyst showed more stable DRM activity than the Ni–Mo2C catalyst.
Simple salts of abundant metals (Fe, Bi, and Ti) supported on montmorillonite as efficient and recyclable catalysts for regioselective intramolecular and intermolecular hydroalkoxylation reactions of double bonds and tandem processes
Authors: Notar Francesco Irene , Cacciuttolo Bastien , Pascu Oana , Aymonier Cyril , Pucheault Mathieu , Antoniotti Sylvain
Published: February 2016

Montmorillonites doped with metal cations are efficient and recyclable catalysts for hydroalkoxylation reactions and amenable to flow chemistry.
Impact of carbon nanotubes on the mobility of sulfonamide antibiotics in sediments in the Xiangjiang River
Authors: Su Chang , Zeng Guang-Ming , Gong Ji-Lai , Yang Chun-Ping , Wan Jia , Hu Liang , Hua Shan-Shan , Guo Yan-Yan
Published: February 2016

Carbon nanotubes could limit the mobility of sulfonamide antibiotics in sediment and such an impact was affected by adsorption affinity.
Microwave-enhanced aqueous biphasic dehydration of carbohydrates to 5-hydroxymethylfurfural
Authors: Wrigstedt P. , Keskiväli J. , Repo T.
Published: February 2016

We describe herein an efficient microwave-assisted aqueous biphasic dehydration of carbohydrates to 5-hydroxymethylfurfural (HMF).
A hydrogenated hydroxy-terminated butadiene–acrylonitrile copolymer-based polyurethane elastomer with improved mechanical properties and aging resistance
Authors: Zou Rui , Tan Jing , Liu Kun , Liang Lu , Cheng Xingwang , Zhang Xu , Zhang Liqun , Yue Dongmei
Published: February 2016

A hydrogenated hydroxy-terminated butadiene–acrylonitrile copolymer (HHTBN)-based polyurethane elastomer (PUE) was prepared by using HHTBN as the soft segments in a casting method.
Effects of tailoring and dehydrated cross-linking on morphology evolution of ordered mesoporous carbons
Authors: Zhang Jiaxi , Liu Dandan , Song Huiyu , Liang Zhenxing , Guo Xuefeng , Du Li , Liao Shijun
Published: February 2016

Self-templated in situ construction of organic mesoporous carbon materials through tailoring of micelles and by dehydrated cross-linking effects.
Microstructure, vibrational and visible emission properties of low frequency ultrasound (42 kHz) assisted ZnO nanostructures
Authors: Pandiyarajan Thangaraj , Mangalaraja Ramalinga Viswanathan , Karthikeyan Balasubramanian , Sepulveda-Guzman Selene , Mansilla Héctor D. , Contreras David , Escalona Néstor , Gracia-Pinilla M. A.
Published: February 2016

Size and shape tuneable ZnO nanostructures were prepared by a low frequency ultrasound (42 kHz) route using various organic solvents as the reaction media.
Synthesis and applications of large-area single-layer graphene
Authors: Lin Xiao-Hong , Gai Jing-Gang
Published: February 2016

The progresses in syntheses of large-area single-layer graphene and applications in membrane separation are summarized in this review.
Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes
Authors: Ghosh Arun K. , Reddy Bhavanam Sekhara , Yen Yu-Chen , Cárdenas Emilio L. , Rao Kalapala Venkateswara , Downs Deborah , Huang Xiangping , Tang Jordan , Mesecar Andrew D.
Published: February 2016

Structure-based design and syntheses of potent and highly selective BACE2 inhibitors are described.
Oriented assembly of invisible probes: towards single mRNA imaging in living cells
Authors: Li Xiang-Ling , Zhang Zhuo-Lei , Zhao Wei , Xia Xing-Hua , Xu Jing-Juan , Chen Hong-Yuan
Published: February 2016

We construct a LSPR sensor by invisible oriented probes with zero background for genetic material sensitive detection in living cells.
Interface-induced crystallization and nanostructure formation of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) in polymer blend films and its application in photovoltaics
Authors: Zhong Yufei , Suzuki Kaori , Inoue Daishi , Hashizume Daisuke , Izawa Seiichiro , Hashimoto Kazuhito , Koganezawa Tomoyuki , Tajima Keisuke
Published: February 2016

Nanorod-shaped crystals of PCBM grew in polymer blend films from the interface of pre-crystallized PCBM films.
Molecular surface functionalization to enhance the power output of triboelectric nanogenerators
Authors: Wang Sihong , Zi Yunlong , Zhou Yu Sheng , Li Shengming , Fan Fengru , Lin Long , Wang Zhong Lin
Published: February 2016

For the enhancement of triboelectric nanogenerator’s output performance, the method of using self-assembled monolayers to functionalize surfaces is introduced.
Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing
Authors: Hajiali Hadi , Summa Maria , Russo Debora , Armirotti Andrea , Brunetti Virgilio , Bertorelli Rosalia , Athanassiou Athanassia , Mele Elisa
Published: February 2016

Electrospun nanofibers of alginate containing lavender essential oil with antimicrobial and anti-inflammatory properties for the treatment of UV-induced skin burns.
Nanosheet-pore topographical titanium substrates: a biophysical regulator of the fate of mesenchymal stem cells
Authors: Xu Kui , Shen Xinkun , Chen Weizhen , Mu Caiyun , Jiang Chao , Zhao Yongchun , Cai Kaiyong
Published: February 2016

Sub-micrometer nanosheet-pore topographic titanium substrates are fabricated with a distinct effect on the adhesion and osteogenic differentiation of MSCs in vitro.
Inflammatory and immuno-reactivity in mice induced by intramuscular implants of HSNGLPL peptide grafted-polyurethane
Authors: Xiao Jiangwei , Huang Cao , Shi Dandan , Zhu Rong , Gu Ruicai , Wang Huan , Wu Gang , Liao Hua
Published: February 2016

Synthetic peptide-based polyurethanes (PUs), introduced as bioactive agents and possessing impressive properties, have emerged as attractive functional biomaterials for tissue regeneration.
Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments
Authors: Paul Arghya , Manoharan Vijayan , Krafft Dorothee , Assmann Alexander , Uquillas Jorge Alfredo , Shin Su Ryon , Hasan Anwarul , Hussain Mohammad Asif , Memic Adnan , Gaharwar Akhilesh K. , Khademhosseini Ali
Published: February 2016

We report the development of a nanoclay-rich bioactive hydrogel for bone regeneration therapy applications.
Design of noncentrosymmetric perovskites from centric and acentric basic building units
Authors: Young Joshua , Lalkiya Parth , Rondinelli James M.
Published: February 2016

We present a detailed crystal-chemistry approach to lift inversion symmetry in inorganic crystals.
Lanthanide metal–organic frameworks assembled from a fluorene-based ligand: selective sensing of Pb2+ and Fe3+ ions
Authors: Li Liang , Chen Qiang , Niu Zhigang , Zhou Xinhui , Yang Tao , Huang Wei
Published: February 2016

A series of fluorene-based Ln-MOFs with 3D neutral network are reported. Eu-MOF can act as the highly sensitive sensor to Pb2+ and Fe3+ ions in aqueous solution by fluorescence enhancement and quenching, respectively. The dynamic and static quenching constants of Fe3+ are obtained.
Long-term performance of a 200 liter modularized microbial fuel cell system treating municipal wastewater: treatment, energy, and cost
Authors: Ge Zheng , He Zhen
Published: February 2016

A modularized microbial fuel cell system can effectively treat primary effluent and use the produced energy to offset part of its energy consumption.
Highly-sensitive Eu3+ ratiometric thermometers based on excited state absorption with predictable calibration
Authors: Souza Adelmo S. , Nunes Luiz A. O. , Silva Ivan G. N. , Oliveira Fernando A. M. , da Luz Leonis L. , Brito Hermi F. , Felinto Maria C. F. C. , Ferreira Rute A. S. , Júnior Severino A. , Carlos Luís D. , Malta Oscar L.
Published: February 2016

Thermally excited state absorption in Eu3+ is used to propose a new ratiometric luminescent thermometer with a predicted calibration factor.
A search for blues brothers: X-ray crystallographic/spectroscopic characterization of the tetraarylbenzidine cation radical as a product of aging of solid magic blue
Authors: Talipov Marat R. , Hossain Mohammad M. , Boddeda Anitha , Thakur Khushabu , Rathore Rajendra
Published: February 2016

Identification of ‘blues brothers’ formed upon slow decomposition of solid magic blue led to the design of a more robust oxidant named ‘blues cousin’.
One synthesis: two redox states. Temperature-oriented crystallization of a charge transfer {Fe2Co2} square complex in a {FeIILSCoIIILS}2 diamagnetic or {FeIIILSCoIIHS}2 paramagnetic state
Authors: De Siddhartha , Jiménez Juan-Ramón , Li Yanling , Chamoreau Lise-Marie , Flambard Alexandrine , Journaux Yves , Bousseksou Azzedine , Lescouëzec Rodrigue
Published: February 2016

The reaction of [FeIII(Tp)(CN)3]− with [CoII(vbik)2(S)2]2+ leads selectively to the crystallization of cyanide-bridged diamagnetic {FeIILSCoIIILS}2 charge-transfer complexes at 5 °C or paramagnetic {FeIIILSCoIIHS}2 ones at 35 °C.
Inhibition studies of Helicobacter pylori urease with Schiff base copper(ii) complexes
Authors: You Zhonglu , Liu Mingyang , Wang Cunfang , Sheng Guihua , Zhao Xinlu , Qu Dan , Niu Fang
Published: February 2016

Nine new copper(ii) complexes derived from various Schiff bases were prepared. Five complexes show effective urease inhibitory activities. Complex5has the most effective activity against urease, with a mixed competitive inhibition mechanism.
Gold/gallium-catalyzed annulation of 1,3-dicarbonyl compounds and cyclopropylacetylenes for synthesis of substituted cyclopentenes
Authors: Dong Boliang , Xi Yumeng , Su Yijin , Akhmedov Novruz G. , Petersen Jeffrey L. , Shi Xiaodong
Published: February 2016

An efficient synthesis of substituted cyclopentenes through gold/gallium-catalyzed annulation of 1,3-dicarbonyl compounds and cyclopropylacetylenes is achieved.
Synthesis of eugenol-based multifunctional monomers via a thiol–ene reaction and preparation of UV curable resins together with soybean oil derivatives
Authors: Dai Jinyue , Jiang Yanhua , Liu Xiaoqing , Wang Jinggang , Zhu Jin
Published: February 2016

Eugenol-based multifunctional monomers with high reactivity and low viscosity were proved to be effective monomers to enhance the properties of soybean oil-based UV-coatings.
Highly stable poly(ethylene glycol)-grafted alkaline anion exchange membranes
Authors: Yang Congrong , Wang Suli , Ma Wenjia , Zhao Shixiong , Xu Ziqi , Sun Gongquan
Published: February 2016

PEG-grafted SEBS-based alkaline anion exchange membranes show excellent mechanical, thermal and chemical stability. The ion-conducting channels are enlarged by PEG-grafting, significantly enhancing the conductivity.
Reliability assessment of HV substations equipped with fault current limiter considering changes of failure rate of components
Authors: Yousefi Hossein , Mirzaie Mohammad , Aminifar Farrokh
Published: February 2016

Owing to the increasing electricity load demand on one hand and in order to have a reliable electric network on the other hand, constructions of new transmission lines and generation sources are extremely essential. Such expansions, however, raise the fault current level which can even exceed the maximum short‐circuit level rating of the circuit breakers (CBs). High fault current, in addition to the adverse effect on the CB function, can damage other substation equipment suddenly or over the time. To this end, severity of the fault current is a key factor in the substation reliability assessment. In this context, fault current limiters (FCLs) which are employed to decline the fault current level need to be precisely modelled and their impact should be extensively studied. In this study, the effect of FCL on the failure rate of substation equipment is first investigated. A computational technique for assessing the substation reliability is accordingly devised. As the location of FCL installation in a given substation or in substations with different arrangements would not be the same, various credible configurations are incorporated here. The results show that from the perspective of reliability indices, double‐bus double‐breaker and one breaker and a half configurations are more suitable for FCL installation.
Overview of Facial Plastic Surgery and Current Developments
Authors: Chuang Jessica , Barnes Christian , Wong Brian
Published: February 2016

Facial plastic surgery is a multidisciplinary specialty largely driven by otolaryngology but includes oral maxillary surgery, dermatology, ophthalmology, and plastic surgery. It encompasses both reconstructive and cosmetic components. The scope of practice for facial plastic surgeons in the United States may include rhinoplasty, browlifts, blepharoplasty, facelifts, microvascular reconstruction of the head and neck, craniomaxillofacial trauma reconstruction, and correction of defects in the face after skin cancer resection. Facial plastic surgery also encompasses the use of injectable fillers, neural modulators (e.g., BOTOX Cosmetic, Allergan Pharmaceuticals, Westport, Ireland), lasers, and other devices aimed at rejuvenating skin. Facial plastic surgery is a constantly evolving field with continuing innovative advances in surgical techniques and cosmetic adjunctive technologies. This article aims to give an overview of the various procedures that encompass the field of facial plastic surgery and to highlight the recent advances and trends in procedures and surgical techniques.
Atomic scale understanding of magnetic properties in Ni50Fe35Co15
Authors: Herojit Singh L. , Govindaraj R. , Ravishankar C. , Rajagopalan S. , Amarendra G.
Published: February 2016

Mössbauer spectroscopic studies have been carried out at different temperatures across ferromagnetic to paramagnetic transition in Ni50Fe35Co15 and the evolution of hyperfine parameters such as centre shift and magnetic hyperfine fields with temperature has been studied. Mössbauer spectrum obtained at 300 K in Ni50Fe35Co15 exhibiting fcc crystal structure is a six line pattern with the mean value of the hyperfine field close to 33 Tesla. Ferromagnetic to paramagnetic transition has been observed to occur in this system around 895 K matching with that of magnetization results. Debye temperature of this nickel rich alloy is deduced to be around 470 K matching with that of Ni. Effect of prolonged annealing at 750 K on the magnetic property is also investigated with respect to the thermal stability of the alloy .
Analytically solvable chaotic oscillator based on a first-order filter
Authors: Corron Ned J. , Cooper Roy M. , Blakely Jonathan N.
Published: February 2016

A chaotic hybrid dynamical system is introduced and its analytic solution is derived. The system is described as an unstable first order filter subject to occasional switching of a set point according to a feedback rule. The system qualitatively differs from other recently studied solvable chaotic hybrid systems in that the timing of the switching is regulated by an external clock. The chaotic analytic solution is an optimal waveform for communications in noise when a resistor-capacitor-integrate-and-dump filter is used as a receiver. As such, these results provide evidence in support of a recent conjecture that the optimal communication waveform for any stable infinite-impulse response filter is chaotic.
High performance of SDC and GDC core shell type composite electrolytes using methane as a fuel for low temperature SOFC
Authors: Irshad Muneeb , Siraj Khurram , Raza Rizwan , Javed Fayyaz , Ahsan Muhammad , Shakir Imran , Rafique Muhammad Shahid
Published: February 2016

Nanocomposites Samarium doped Ceria (SDC), Gadolinium doped Ceria (GDC), core shell SDC amorphous Na2CO3 (SDCC) and GDC amorphous Na2CO3 (GDCC) were synthesized using co-precipitation method and then compared to obtain better solid oxide electrolytes materials for low temperature Solid Oxide Fuel Cell (SOFCs). The comparison is done in terms of structure, crystallanity, thermal stability, conductivity and cell performance. In present work, XRD analysis confirmed proper doping of Sm and Gd in both single phase (SDC, GDC) and dual phase core shell (SDCC, GDCC) electrolyte materials. EDX analysis validated the presence of Sm and Gd in both single and dual phase electrolyte materials; also confirming the presence of amorphous Na2CO3 in SDCC and GDCC. From TGA analysis a steep weight loss is observed in case of SDCC and GDCC when temperature rises above 725 °C while SDC and GDC do not show any loss. The ionic conductivity and cell performance of single phase SDC and GDC nanocomposite were compared with core shell GDC/amorphous Na2CO3 and SDC/ amorphous Na2CO3 nanocomposites using methane fuel. It is observed that dual phase core shell electrolytes materials (SDCC, GDCC) show better performance in low temperature range than their corresponding single phase electrolyte materials (SDC, GDC) with methane fuel.
Evolution of interface chemistry and dielectric properties of HfO2/Ge gate stack modulated by Gd incorporation and thermal annealing
Authors: He Gang , Zhang Jiwen , Sun Zhaoqi , Lv Jianguo , Chen Hanshuang , Liu Mao
Published: February 2016

In current work, effects of rapid thermal annealing (RTA) on the interface chemistry and electrical properties of Gd-doped HfO2 (HGO)/Ge stack have been investigated systematically. It has been demonstrated that the presence of GeOx interfacial layer between HfGdO and Ge is unavoidable and appropriate annealing can improve metal-oxide-semiconductor device characteristics such as interface state density, accumulation capacitance, frequency dispersion, and leakage current. The involved leakage current conduction mechanisms for metal-oxide-semiconductor (MOS) capacitors based on sputtered HGO/Ge gate stacks with optimal annealed temperature also have been discussed in detail. As a result, the Al/HGO barrier height and the band offset of HGO/Ge gate stack have been determined precisely.
Tripogon loliiformis elicits a rapid physiological and structural response to dehydration for desiccation tolerance
Authors: Karbaschi Mohammad Reza , Williams Brett , Taji Acram , Mundree Sagadevan G.
Published: February 2016

Resurrection plants can withstand extreme dehydration to an air-dry state and then recover upon receiving water. Tripogon loliiformis (F.Muell.) C.E.Hubb. is a largely uncharacterised native Australian desiccation-tolerant grass that resurrects from the desiccated state within 72 h. Using a combination of structural and physiological techniques the structural and physiological features that enable T. loliiformis to tolerate desiccation were investigated. These features include: (i) a myriad of structural changes such as leaf folding, cell wall folding and vacuole fragmentation that mitigate desiccation stress, (ii) potential role of sclerenchymatous tissue within leaf folding and radiation protection, (iii) retention of ~70% chlorophyll in the desiccated state, (iv) early response of photosynthesis to dehydration by 50% reduction and ceasing completely at 80 and 70% relative water content, respectively, (v) a sharp increase in electrolyte leakage during dehydration, and (vi) confirmation of membrane integrity throughout desiccation and rehydration. Taken together, these results demonstrate that T. loliiformis implements a range of structural and physiological mechanisms that minimise mechanical, oxidative and irradiation stress. These results provide powerful insights into tolerance mechanisms for potential utilisation in the enhancement of stress-tolerance in crop plants.
Preantral follicle density in ovarian biopsy fragments and effects of mare age
Authors: Alves K. A. , Alves B. G. , Gastal G. D. A. , Haag K. T. , Gastal M. O. , Figueiredo J. R. , Gambarini M. L. , Gastal E. L.
Published: February 2016

The aims of the present study were to: (1) evaluate preantral follicle density in ovarian biopsy fragments within and among mares; (2) assess the effects of mare age on the density and quality of preantral follicles; and (3) determine the minimum number of ovarian fragments and histological sections needed to estimate equine follicle density using a mathematical model. The ovarian biopsy pick-up method was used in three groups of mares separated according to age (5–6, 7–10 and 11–16 years). Overall, 336 preantral follicles were recorded with a mean follicle density of 3.7 follicles per cm2. Follicle density differed (P < 0.05) among animals, ovarian fragments from the same animal, histological sections and age groups. More (P < 0.05) normal follicles were observed in the 5–6 years (97%) than the 11–16 years (84%) age group. Monte Carlo simulations showed a higher probability (90%; P < 0.05) of detecting follicle density using two experimental designs with 65 histological sections and three to four ovarian fragments. In summary, equine follicle density differed among animals and within ovarian fragments from the same animal, and follicle density and morphology were negatively affected by aging. Moreover, three to four ovarian fragments with 65 histological sections were required to accurately estimate follicle density in equine ovarian biopsy fragments.
Cross-linguistic lexical and syntactic co-activation in L2 sentence processing
Authors: Hopp Holger
Published: February 2016

This study investigates under which conditions the L1 syntax is activated in L2 on-line sentence comprehension. We study whether cross-linguistic syntactic activation of the L1 word order is affected by lexical activation of the first language (L1) by virtue of cognate words. In two eye-tracking experiments, German-English bilinguals and English natives read English sentences containing reduced relative clauses whose surface word order partially overlaps with German embedded clauses. The verbs used were either German-English cognates or matched control verbs. The results show lexical cognate facilitation and syntactic co-activation of L1 word order, with the latter being moderated by proficiency and cognate status. Critically, syntactic co-activation is found only with English control words. We argue that fleeting co-activation of the L1 syntax becomes measurable under higher demands of lexical processing, while cognate facilitation frees resources for inhibition of the L1 syntax and target-like syntactic processing.
Coreference and discourse coherence in L2
Authors: Grüter Theres , Rohde Hannah , Schafer Amy J.
Published: February 2016

Discourse-level factors, such as event structure and the form of referential expressions, play an important role in native speakers’ referential processing. This paper presents an experiment with Japanese- and Korean-speaking learners of English, investigating the extent to which discourse-level biases that have gradient effects in L1 speakers are also implicated in L2 speakers’ coreference choices. Results from a story continuation task indicate that biases involving referential form were remarkably similar for L1 and L2 speakers. In contrast, event structure, indicated by perfective versus imperfective aspect, had a more limited effect on L2 speakers’ referential choices. The L2 results are discussed in light of existing accounts of L1 reference processing, which assume that referential choices are shaped by speakers’ continually updated expectations about what is likely to be mentioned next, and argued to reflect L2 speakers’ reduced reliance on expectations.
Discy dwarf disruption and the shape of the Galactic halo
Authors: Gibbons S. L. J. , Belokurov V. , Erkal D. , Evans N. W.
Published: February 2016

The shape of the Galactic dark halo can, in principle, be inferred through modelling of stellar tidal streams in the Milky Way halo. The brightest and the longest of these, the Sagittarius stream, reaches out to large Galactocentric distances and hence can deliver the tightest constraints on the Galaxy's potential. In this contribution, we revisit the idea that the Sagittarius Stream was formed from a rotating progenitor. We demonstrate that the angle between the disc's angular momentum and the progenitor's orbital angular momentum does not remain constant throughout the disruption. Instead, it undergoes a dramatic evolution caused, in part, by the changes in the progenitor's moment of inertia tensor. We show that, even in a spherical potential, the streams produced as a result of a discy dwarf disruption appear to be ‘precessing’. Yet, this debris plane evolution is illusory as it is solely caused by the swaying and wobbling of the progenitor's disc. Stream plane precession is therefore not an unambiguous indicator of asphericity of the dark halo.
A Human Factors Engineering Study of the Medication Delivery Process during an Anesthetic
Authors: Yang Yushi , Rivera Antonia Joy , Fortier Christopher R. , Abernathy James H.
Published: February 2016

AbstractAbstract

In a work system analysis using human factors principles conducted in the operating rooms and pharmacy of a single large academic medical center, prefilled syringe were associated with simpler use and fewer system vulnerabilities compared with self-filled syringe. Use of prefilled syringe might improve the safety of perioperative medication delivery if these findings are confirmed in larger multicenter studies.

Background

Prefilled syringes (PFS) have been recommended by the Anesthesia Patient Safety Foundation. However, aspects in PFS systems compared with self-filled syringes (SFS) systems have never been explored. The aim of this study is to compare system vulnerabilities (SVs) in the two systems and understand the impact of PFS on medication safety and efficiency in the context of anesthesiology medication delivery in operating rooms.

Methods

This study is primarily qualitative research, with a quantitative portion. A work system analysis was conducted to analyze the complicated anesthesia work system using human factors principles and identify SVs. Anesthesia providers were shadowed: (1) during general surgery cases (n = 8) exclusively using SFS and (2) during general surgery cases (n = 9) using all commercially available PFS. A proactive risk assessment focus group was followed to understand the risk of each identified SV.

Results

PFS are superior to SFS in terms of the simplified work processes and the reduced number and associated risk of SVs. Eight SVs were found in the PFS system versus 21 in the SFS system. An SV example with high risk in the SFS system was a medication might need to be “drawn-up during surgery while completing other requests simultaneously.” This SV added cognitive complexity during anesthesiology medication delivery. However, it did not exist in the PFS system.

Conclusions

The inclusion of PFS into anesthesiology medication delivery has the potential to improve system safety and work efficiency. However, there were still opportunities for further improvement by addressing the remaining SVs and newly introduced complexity.
The use of pembrolizumab for the treatment of metastatic uveal melanoma
Authors: Kottschade Lisa A. , McWilliams Robert R. , Markovic Svetomir N. , Block Matthew S. , Villasboas Bisneto Jose , Pham Anthony Q. , Esplin Brandt L. , Dronca Roxana S.
Published: February 2016

Uveal melanoma is a rare type of melanoma, with only five to seven cases per one million persons diagnosed each year. Patients with metastatic melanoma of uveal origin tend to have lower response rates on traditional therapies. Herein we report our experience with 10 patients with metastatic uveal melanoma (MUM) who received pembrolizumab. Eligible patients were more than or equal to 18 years old, had unresectable MUM, progressed on prior ipilimumab therapy, had good performance status (Eastern Cooperative Oncology Group of 0 or 1), and adequate organ and marrow function. Patients could have central nervous system disease, but needed to be clinically stable. Patients were treated with 2 mg/kg pembrolizumab intravenously over 30 min every 3 weeks until disease progression, unacceptable toxicity, or for up to 2 years. Between April 2014 and October 2014, we treated a total of 10 patients with MUM with pembrolizumab. Median age was 65 years, with 70% being female. As of the data cutoff date of 14 May 2015, median progression-free survival was 18 weeks (range 3.14–49.3 weeks), with four patients still currently receiving therapy. Of eight evaluable patients, there was one complete response, two partial responses, and one patient with stable disease. Four patients had rapidly progressive disease. Toxicities were as expected and were usually grade 1/2 in nature. Although this cohort of patients was small, to our knowledge this is the first such report of outcomes in uveal melanoma patients being treated with anti-PD1 therapy. In the absence of a clinical trial, treatment with pembrolizumab appears to be a viable option for patients with MUM.
Aquaporin 1 protein expression is associated with BRAF V600 mutation and adverse prognosis in cutaneous melanoma
Authors: Imrédi Eleonóra , Tóth Béla , Doma Viktória , Barbai Tamás , Rásó Erzsébet , Kenessey István , Tímár József
Published: February 2016

Despite experimental findings suggesting the prognostic significance of Aquaporin 1 (AQP1) in human melanoma, no published clinical data are available. We studied the expression of AQP1 protein in cutaneous melanoma, correlated our findings with standard histological and genetic markers, and long-term clinical follow-up. Our study evaluated the AQP1 protein expression in 78 melanoma patients, representing two predefined risk cohorts using the immune labeling technique with commercially available anti-AQP1 antibodies on routinely formalin-fixed and paraffin-embedded tumor tissue samples. BRAF V600E mutation analyses were carried out successfully in 70 patients using PCR and restriction fragment length polymorphism analyses, followed by confirmatory analysis with the Sanger sequencing technique. AQP1-expressing melanoma cells were found in 52 cases (66.7%, median H-score=124.24). Significantly higher AQP1 H-scores (P=0.047) were found in the ‘high-risk’ patients. No correlations were found with the established histological markers, such as mitotic index (P=0.42), Clark level (P=0.95), and Breslow thickness (P=0.51). BRAF V600 mutation analyses were successful in 89%, and showed a two times higher mutation frequency in the ‘high-risk’ group. The BRAF V600 mutations were significantly associated with AQP1 expression (P=0.014). Long-term follow-up indicated a reduced progression-free survival (P=0.036) and overall survival (P=0.017) for the AQP1-positive cutaneous melanoma patients. AQP1 expression is likely to be associated with an adverse prognosis in cutaneous melanoma.