bluuebunny/crossref_metadata_2025 huggingface dataset:
A Highly Compact Sext-band Bandpass Filter with Simple Structure and Wide Bandwidth
Authors: Bai Lei , Zhuang Yiqi , Zeng Zhibin
Published: March 2023

A highly compact sext-band bandpass filter (BPF) is investigated in this paper, which adopts quad-section stepped impedance resonators (SIRs) along with a series of multiple open stubs. This quad-section SIRs are constructed by tri-section SIR loaded L-shaped resonator. To achieve compact size, the filter utilizes tri-section SIR and is embedded in the double L-shaped resonators. Aseries of multiple open stubs are introduced to improve fractional bandwidth and the return loss. A sext-band BPF centering at 1.12, 2,12, 2,78, 5,59, 6.59 and 8.97 GHz has been designed and fabricated. This highly compact sext-band with wide bandwidth and simple structure is constructed on Rogers 4350 with a dielectric constant of 3.66 and a height of 0.508mm. The overall size of the fabricated filter  is 0.15λ g × 0.16λ g . Good agreements are observed between the simulated and measured results.
Novel point mutation and intronic mutations of RB1 gene in retinoblastoma patients in Indonesia
Authors: Umar Batari Todja , Rimayanti Ulfah , Pagarra Halimah , Budu  , Massi Nasrum , Muhiddin Habibah Setyawati
Published: March 2023

BACKGROUND Retinoblastoma (RB) is an inherited disorder caused by the RB1 gene mutation in retinal cells or germline mutation. Identifying the specific mutation is crucial for prognosis, inheritance risk assessment, and treatment planning. This study aimed to identify the germline mutation in the RB1 gene in patients with RB and their parents from the eastern part of Indonesia.

METHODS This observational analytic study recruited patients with RB and their parents between 2016 and 2018 at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. The normal control subjects were children from the outpatient clinic at the Department of Ophthalmology, Universitas Hasanuddin Hospital. Ophthalmic examinations and peripheral blood tests were performed in RB patients, their parents, and control subjects. Genomic DNA was isolated from blood leukocytes and amplified using conventional PCR. Hotspot exons 8, 10, 14, 17, and 22 were screened for mutations using the Sanger method.

RESULTS There were 21 patients with RB (16 unilateral and 5 bilateral) and 14 normal subjects. Of the 184 variations detected in RB patients, 164 were also found in normal subjects. 19 intronic mutations in introns 10, 16, 17, and 21, and 1 novel missense mutation in exon 17 were identified. Parental testing revealed 8 substitutions in exon 17 and 5 intronic mutations in introns 16 and 17 of the parents. None of the variations in exons were passed to their children.

CONCLUSIONS This study found a novel missense mutation in exon 17 of the RB1 gene.
Highly efficient method for cutting position selection of an x-ray mono-capillary lens based on an improved SCA-CSA algorithm
Authors: Huang Yi , Zhang Zhaofei , Deng Chuanlu , Chen Zhenyi , Yang Hai , Hu Chengyong , Zhang Xiaobei , Wang Tingyun
Published: March 2023

In order to efficiently select the optimal cutting position of x-ray mono-capillary lenses, an improved sine cosine algorithm-crow search algorithm (SCA-CSA) algorithm is proposed, which combines the sine cosine algorithm with the crow search algorithm, with further enhancements. The fabricated capillary profile is measured using an optical profiler; then the surface figure error for interest regions of the mono-capillary can be evaluated using the improved SCA-CSA algorithm. The experimental results indicate that the surface figure error in the final capillary cut region is about 0.138 µm, and the runtime is 2.284 s. When compared with the traditional metaheuristic algorithm, the particle swarm optimization algorithm, the improved SCA-CSA algorithm, enhances the surface figure error metric by two orders of magnitude. Furthermore, the standard deviation index of the surface figure error metric for 30 runs also improves by more than 10 orders of magnitude, demonstrating the superior performance and robustness of the algorithm. The proposed method provides significant support for the development of precise cuttings of mono-capillaries.
Does the Complex Group Index Satisfy the Kramers-Kronig Relations in Linear Optics?
Authors: Shabdurasulov Kirill
Published: March 2023

By combining the formula for the group complex refractive index with the Kramers-Kronig relations connecting the real and imaginary parts of the complex susceptibility in the context of linear optics, we rigorously prove the existence of the Kramers-Kronig relation for the imaginary part of the group refractive index, and non-existence of the relation for the real part. We briefly discuss the various theoretical implications this result.
Maternal perception of fetal movements: Views, knowledge and practices of women and health providers in a low-resource setting
Authors: Weller Katinka , Housseine Natasha , Khamis Rashid S. , Meguid Tarek , Hofmeyr G. Justus , Browne Joyce L. , Rijken Marcus J.
Published: March 2023

The study assessed perception, knowledge, and practices regarding maternal perception of fetal movements (FMs) among women and their healthcare providers in a low-resource setting. Semi-structured interviews, questionnaires and focus group discussions were conducted with 45 Zanzibar women (18 antenatal, 28 postpartum) and 28 health providers at the maternity unit of Mnazi Mmoja Hospital, Zanzibar, Tanzania. Descriptive and thematic analyses were conducted to systematically extract subthemes within four main themes 1) knowledge/awareness, 2) behavior/practice, 3) barriers, and 4) ways to improve practice. Within the main themes it was found that 1) Women were instinctively aware of (ab)normal FM-patterns and healthcare providers had adequate knowledge about FMs. 2) Women often did not know how to monitor FMs or when to report concerns. There was inadequate assessment and management of (ab)normal FMs. 3) Barriers included the fact that women did not feel free to express concerns. Healthcare providers considered FM-awareness among women as low and unreliable. There was lack of staff, time and space for FM-education, and no protocol for FM-management. 4) Women and health providers recognised the need for education on assessment and management of (ab)normal FMs. In conclusion, women demonstrated adequate understanding of FMs and perceived abnormalities of these movements better than assumed by health providers. There is a need for more evidence on the effect of improving knowledge and awareness of FMs to construct evidence-based guidelines for low resource settings.
Sous-vide processing of silver carp: Effect of processing temperature and cold storage duration on the microbial quality of the product as well as modeling by artificial neural networks
Authors: Hosseini Seyed Vali , Pero Milad , Hoseinabadi Zahra , Tahergorabi Reza , Kazemzadeh Shirin , Santos Alemán Ricardo , Abrahan Marcia Fuentes Jhunior , Montero Fernández Ismael , Calderon David P. , Feas Sanchez Xesus
Published: March 2023

Silver carp (Hypophthalmichthys molitrixi) was processed by sous-vide method at different temperatures (60, 65, 70, and 75°C). Then, the microbiological quality of the processed samples was monitored during cold storage (4°C) for 21 days. The target microorganisms were Enterobacteriaceae, Lactic Acid bacteria (LAB), Pseudomonas, Psychrotrophs, and total viable count (TVC). In samples processed at 75°C, the presence of Enterobacteriaceae, Pseudomonas and Psychrotrophs were not detectable up to 15 days of storage and lactic acid bacteria were not detectable even at the end of the storage period. A radial basis function neural network (RBFNN) model was established to predict the changes in the microbial content of silver carp. In this step, the relationship between processing temperature and storage duration on microbial growth was modeled by ANNs (artificial neural networks). The optimal ANN topology for modeling Enterobacteriaceae, Pseudomonas, and Psychrotroph contained 9 neurons in the hidden layer, but it contained 15 and 14 neurons for TVC and LAB, respectively. By experimenting with the temperature of -80°C, it was revealed that the obtained ANN model has a high potential for prediction.
Mental health and gender-based violence: An exploration of depression, PTSD, and anxiety among adolescents in Kenyan informal settlements participating in an empowerment intervention
Authors: Friedberg Rina , Baiocchi Michael , Rosenman Evan , Amuyunzu-Nyamongo Mary , Nyairo Gavin , Sarnquist Clea
Published: March 2023

Objective

This study examines the prevalence of depression, anxiety, and post-traumatic stress disorder (PTSD) among adolescents attending schools in several informal settlements of Nairobi, Kenya. Primary aims were estimating prevalence of these mental health conditions, understanding their relationship to gender-based violence (GBV), and assessing changes in response to an empowerment intervention.

Methods

Mental health measures were added to the final data collection point of a two-year randomized controlled trial (RCT) evaluating an empowerment self-defense intervention. Statistical models evaluated how past sexual violence, access to money to pay for a needed hospital visit, alcohol use, and self-efficacy affect both mental health outcomes as well as how the intervention affected female students’ mental health.

Findings

Population prevalence of mental health conditions for combined male and female adolescents was estimated as: PTSD 12.2% (95% confidence interval 10.5–15.4), depression 9.2% (95% confidence interval 6.6–10.1) and anxiety 17.6% (95% confidence interval 11.2% - 18.7%). Female students who reported rape before and during the study-period reported significantly higher incidence of all mental health outcomes than the study population. No significant differences in outcomes were found between female students in the intervention and standard-of-care (SOC) groups. Prior rape and low ability to pay for a needed hospital visit were associated with higher prevalence of mental health conditions. The female students whose log-PTSD scores were most lowered by the intervention (effects between -0.23 and -0.07) were characterized by high ability to pay for a hospital visit, low agreement with gender normative statements, larger homes, and lower academic self-efficacy.

Conclusion

These data illustrate a need for research and interventions related to (1) mental health conditions among the young urban poor in low-income settings, and (2) sexual violence as a driver of poor mental health, leading to a myriad of negative long-term outcomes.
Rotational fishing enables biodiversity recovery and provides a model for oyster (Ostrea edulis) habitat restoration
Authors: Kennon Naomi A. , Robertson-Jones Alexander , Jemmett Sebastian , Hugh-Jones Tristan , Bell Michael C. , Sanderson William G.
Published: March 2023

Reefs formed byOstrea edulis, the European native oyster, are among many biogenic habitats that have declined globally. European oyster habitats are now rare, and undisturbed examples have not been described. As more is understood of the ecosystem services provided by the reefs, oyster restoration efforts are on the rise, becoming a more prominent component of Europe’s portfolio of marine conservation practices. It is therefore important to establish the relationship between the development of oyster reefs and their associated biotic community if the biodiversity benefits are to be accurately predicted and the progress of restoration projects assessed. The Loch Ryan oyster fishery in Southwest Scotland is the last of its type and uses a rotational harvest system where different areas are fished each year and then left for six years before they are fished again. This provided an opportunity to study the effect of oyster reef development and biodiversity gain at different stages of habitat recovery. In this study three treatments were surveyed for faunal biodiversity, oyster shell density and oyster shell percentage cover. Treatments were plots that had been harvested one year before, two years before, and six years before the study. The treatments were surveyed with SCUBA using a combination of video transects and photo quadrats. Oyster shell density, oyster shell percent cover and macrofaunal biodiversity differed significantly between treatments, with the highest values observed in the six-year treatment. Shell density was 8.5 times higher in the six-year treatment compared to the one-year treatment, whilst Shannon-Wiener’s diversity was 60.5% higher, and Margalef’s richness 68.8% higher. Shell density and percent cover had a significant positive relationship with macrofaunal biodiversity. This is probably due to the provision of increased structural complexity in the matrix of live and dead oyster shells. Projecting forward the trend of biodiversity increase in relation to time since disturbance indicates that full recovery would take approximately ten years in which time diversity (Shannon-Wiener) would probably have doubled. The findings from the present study indicate the probable biodiversity benefits of oyster habitat restoration and a cost-effective metric (shell density) to judge progress in restoration projects.
Longitudinal trajectories of functional recovery after hip fracture
Authors: Dakhil Shams , Saltvedt Ingvild , Benth Jūratė Šaltytė , Thingstad Pernille , Watne Leiv Otto , Bruun Wyller Torgeir , Helbostad Jorunn L. , Frihagen Frede , Johnsen Lars Gunnar , Taraldsen Kristin
Published: March 2023

Background

There is limited evidence regarding predictors of functional trajectories after hip fracture. We aimed to identify groups with different trajectories of functional recovery the first year after hip fracture, and to determine predictors for belonging to such groups.

Methods

This longitudinal study combined data from two large randomized controlled trials including patients with hip fracture. Participants were assessed at baseline, four and 12 months. We used the Nottingham Extended Activities of Daily Living (NEADL) as a measure of instrumental ADL (iADL) and Barthel Index for personal ADL (pADL). A growth mixture model was estimated to identify groups of patients following distinct trajectories of functioning. Baseline characteristics potentially predicting group-belonging were assessed by multiple nominal regression.

Results

Among 726 participants (mean age 83.0; 74.7% women), we identified four groups of patients following distinct ADL trajectories. None of the groups regained their pre-fracture ADL. For one of the groups identified in both ADL outcomes, a steep decline in function was shown the first four months after surgery, and none of the groups showed functional recovery between four and 12 months after surgery.

Conclusions

No groups regained their pre-fracture ADL. Some of the patients with relatively high pre-fracture function, had a steep ADL decline. For this group there is a potential for recovery, but more knowledge and research is needed in this group. These findings could be useful in uncovering groups of patients with different functioning after a hip fracture, and aid in discharge planning.
Morphological characteristics convey social status signals in captive tree sparrows (Passer montanus)
Authors: Lee Ju-Hyun , Sung Ha-Cheol
Published: March 2023

In social animals that form flocks, individuals compete or cooperate to gain access to shared resources. In particular, group-foraging individuals frequently engage in aggressive interactions with conspecifics, including threat displays and physical attacks, in order to acquire food resources. Here, we investigated social interactions in flocks of captive tree sparrows (Passer montanus) to observe the formation of dominance hierarchies. We also examined correlations between social status and morphological traits to identify which physical traits act as indicators of dominance. To do so, we recorded aggressive behaviours (attacks and threats) of tree sparrows caught in two distinct regions in the Republic of Korea (Gwangju and Gurye). After merging the two groups, we examined dominance structures using David’s scores for one month, and we recorded 1,051 aggressive interactions at a feeder in a group of 19 individuals. Using the number of aggressions and attack and threat behaviours, we tested whether morphological traits and sex influenced dominance structures. Aggressions were significantly more frequent in males than in females. However, no significant difference was observed the frequency of between- and within-sex aggression. In addition, differences in the frequency of aggression behaviours were observed between capture-site groups. Dominance structure was significantly correlated with certain morphological traits; specifically, the frequency of attacking behaviours was correlated with bill-nose length, and the frequency of threat displays was correlated with sex and badge size. These results suggest that social signals are closely related to morphological traits that are used to form dominance hierarchies in tree sparrow flocks.
Habitat associations of red-listed epiphytic lichens in Finland
Authors: Nirhamo Aleksi , Pykälä Juha , Jääskeläinen Kimmo , Kouki Jari
Published: March 2023

The Finnish red list shows that the epiphytic lichen flora of Finnish forests is highly threatened and declining steeply. Red lists provide limited information on the habitat associations of threatened species, which could be relevant in informing management and conservation measures. We used documented empirical data and expert assessments to determine for each red-listed (IUCN categories Near Threatened, NT; Vulnerable, VU; Endangered, EN; Critically Endangered, CR; Regionally Extinct, RE) epiphytic lichen species of Finland the following key habitat associations: host tree species, substrate type, habitat type, geographical distribution, preferred microclimate, and minimum required forest and tree age. The most important host tree species were Picea abies (L.) H. Karst. and Populus tremula L. Other tree species of high importance included Sorbus aucuparia L. and Salix caprea L. One fourth of red-listed epiphytic lichens were primarily lignicolous. Most species required old-growth forests (required by 41% of species) or old trees (52%), but many species required only mature forests (36%) or trees (35%). The microclimatic preferences of most red-listed epiphytic lichens consisted of high or intermediate light availability and humidity. Most species whose status had deteriorated were dependent on deciduous trees. The continuous availability of old deciduous trees (especially Populus, Salix and Sorbus) requires special attention in both managed and protected forests. Red-listed epiphytic lichens would be aided by increased forest protection or transitioning to less intensive management regimes.
Család és politika az Anjou-korban
Authors: Farkas Csaba
Published: March 2023

In this study I examine two families in the Angevin era between 1308
(Szécsi’s first appearance in the elite) to 1359 (death of Lack from
kindred Hermán). They had baronial dignities at royal court: Lackfi’s were
masters of horses (from 1326 until 1396), many members of the Szécsi family
were the stewards under reign Charles I and Louis I of Hungary. I analysed
these two families and I focused to the first and second generation. In the
end we can see which were differences between them and their king’s
personal policy with elite. In the elite there was main changes between
first years and the middle of the 14th century.
A huszita betörés a Magyar Királyságba 1428 februárjában
Authors: Kis Iván
Published: March 2023

In my paper I analyze a raid led by the Hussites to the north-west region of the Hungarian Kingdom in February 1428. According to the previous opinion of the historiography of the topic, the route of the campaign was the following: after leaving Bohemia, and crossing the Lesser Carpathians, the Bohemians marched toward Bratislava, and, while attacking and burning down smaller settlements along the way, they turned to Nagyszombat then back to Bohemia. In my study, I examine the relevant charters, letters, and narrative sources of the raid, and I present the information about the defensive actions taken by the king and the magnates of Hungary in the 1420s against the Hussites. Furthermore, I summarize the warfare strategies of the Hussites, including the phenomenon of the so-called “small wars.” By the demonstration of the mentioned aspects, I intend to present a new interpretation concerning the Bohemian raid in 1428. My opinion is that Hussites, after they crossed the Lesser Carpathians in early February, marched not on Bratislava, but they split into two parts. The main troop of the army marched on Nagyszombat and conducted war activities there for the next two weeks. Only a small group of Hussites left toward Bratislava; the latter’s strategy was only rapid predation, accompanied by arson, in order to divide the Hungarian defensive contingents.
Ultrasonographic Transmural Healing in Crohn's Disease
Authors: Zorzi Francesca , Rubin David T. , Cleveland Noa Krugliak , Monteleone Giovanni , Calabrese Emma
Published: March 2023

Therapeutic targets in Crohn's disease (CD) have evolved greatly over the past several decades to include endoscopic improvement along with clinical remission. Yet CD is characterized by transmural damage, and there is increasing evidence of improved outcomes associated with transmural healing. Intestinal ultrasonography is a noninvasive, highly accurate imaging modality that provides real-time results and can assess for transmural healing in CD. In this review, we present the definition of transmural healing by ultrasonography, its comparison with other imaging modalities and with endoscopy, the efficacy of diverse therapies on achieving transmural healing, and data on patient outcomes in those achieving transmural healing. This review can guide clinicians who care for patients with inflammatory bowel disease on the added value of achieving transmural healing and its eventual incorporation as a target of therapy.
Memorias visuales del conflicto armado y la paz en Colombia (2002-2016)
Authors: Amador-Baquiro Juan Carlos
Published: March 2023

El conflicto armado y las iniciativas de paz han sido fenómenos recurrentes en la memoria del pasado reciente en Colombia. Existen iniciativas de tipo periodístico, artístico y político que han registrado parte de los acontecimientos relacionados con estas realidades. En el marco de estas iniciativas, la fotografía de prensa y el arte visual han representado estos hechos como testimonio, huella, ilustración y ficción de lo ocurrido, intentando mostrar aquello de lo que no se puede hablar (Bal, 2014). Además de exponer los hechos ocurridos mediante un lenguaje cercano a las personas, las imágenes pueden favorecer la sensibilización, la reflexión y la toma de posición en las audiencias, aunque también pueden propiciar la sobrerrepresentación, la saturación y la banalización de los acontecimientos (Sontag, 2004). En este contexto de discusión, emergió este libro, el cual indagó las narrativas visuales sobre el conflicto armado y la paz que han sido puestas en circulación, a través de dos diarios de divulgación nacional y cuatro artistas visuales, en el periodo 2002-2016, así como sus relaciones con la configuración de memorias del pasado reciente en Colombia. Para tal efecto, se analizó un corpus de cerca de 120 imágenes por medio de una metodología de tipo iconológico que exploró los atributos de las narrativas visuales frente a las condiciones políticas, sociales, económicas y culturales en las que surgieron estas producciones semióticas. Luego de presentar cada una de las imágenes seleccionadas en los cuatro periodos convulsos ejercidos por los presidentes Álvaro Uribe y Juan Manuel Santos, y de proceder a la sistematización y la interpretación de la información, se organizó la escritura de los hallazgos en cinco capítulos que fueron estructurados en dos grandes momentos (2002 a 2007 y 2008 a 2016) y tres grandes ejes temáticos: narrativas visuales del conflicto armado; narrativas visuales de paz; y memoria y arte visual.
Current aspects of the wound process treatment using dressings (bandages)
Authors: Shmatenko O. P. , Davtian L. L. , Prykhodko T. V. , Kuchmistova O. F. , Tarasenko V. О. , Коziko N. O. , Voronenko D. V. , Osodlo V. V.
Published: March 2023

The review provides information concerning the assortment of modern wound dressings (bandages) which are presented on the pharmaceutical market. The studied group of dressings varies widely in chemical composition and active pharmaceutical ingredients. It has been determined that the development of modern wound dressings provides for the realization of a complex effect on the wound process, which is achieved by the multi-layer structure of the dressing (bandages) with clearly defined functions of each component – the contact layer reduces adhesion to the wound surface; sorption layer provides irreversible sorption, retention and inactivation of wound exudate; pharmacologically active layer influences the main factors of wound process pathogenesis; outer isolating membrane generates wound occlusion.
Conclusions. The events of recent years which related to the Anti-terrorist operation / the Joint Forces Operation in Ukraine indicate the unresolved problem of combat surgical trauma treatment. This is an important issue for the Medical services of the Armed Forces and the health care system of Ukraine. This necessitates expanding the range of wound dressing (bandages) with combined action for military medicine. It has been determined that the treatment in the purulent-necrotic phase of the wound process, it is advisable to use wound dressings with strong osmotic and antibacterial activity and low adhesion to the wound surface. In the second phase of the wound process, it is advisable to use wound dressings with moderate osmotic activity and a combination of antibacterial and reparative properties. In the final phase of the wound process, wound dressings should prevent drying of the wound surface as well as protect and stimulate the growth of granulations.
Obstructive sleep apnea syndrome in children as a multi-disciplinary problem (a review)
Authors: Kuznietsova O. D. , Nedelska S. M. , Kuznietsov А. А.
Published: March 2023

Aim. To analyze the data of modern scientific literature about the etiology, risk factors, pathogenesis, diagnosis and treatment of obstructive sleep apnea (OSA) in children.
Results. The prevalence of OSA in children is about 1–5 %, with a peak incidence between the ages of 2 and 6 years. The main risk factors for OSA include adenotonsillar hypertrophy, obesity, and craniofacial anomalies. Nocturnal and daytime symptoms are clinically distinguished. Nocturnal ones include snoring, mouth breathing, pauses in breathing, restless sleep, enuresis and sweating; daytime symptoms are nasal obstruction, mouth breathing, morning headache, drowsiness, violation in attention concentration and hyperactivity. Nocturnal polysomnography is the gold standard for the diagnosis of OSA, in the absence of which the use of screening systems is possible, in particular – cardiorespiratory monitoring. The apnea/hypopnea index ≥1 per hour is considered a diagnostic criterion for mild OSA in children and differs from that in adults ≥5. Among the most effective treatments for OSA are adenoidectomy, CPAP therapy, intranasal corticosteroids, leukotriene receptor antagonists, and lifestyle modification in obesity is obvious.
Conclusions. The problem of OSA syndrome is underestimated, and the vigilance of physicians as well as diagnostic opportunities of treatment and prevention facilities in Ukraine are quite low. Nocturnal polysomnography or screening diagnostic methods (cardiorespiratory monitoring) should be used in case of suspected OSA. Therapeutic measures for apnea are primarily aimed at eliminating etiological and risk factors. The presence of OSA in children with adenoids is an absolute indication for their removal.
Lymphoproliferative disorder – Castleman’s disease with early childhood-onset in a child (a clinical case)
Authors: Mukvich O. M. , Vdovina N. M. , Klymniuk H. I. , Omelchenko L. I. , Hridina T. A. , Matsiuk N. B.
Published: March 2023

Castleman’s disease (angiofollicular lymphoma, giant lymph node hyperplasia, Castleman’s pseudotumor) is an understudied orphan lymphoproliferative disease with a long period of asymptomatic course and a high risk of malignancy, and variability of its clinical features can cause difficulties in diagnosis.
The aim of the study. To acquaint clinicians and increase the effectiveness of early diagnosis and treatment of Castleman’s disease (CD) in children to prevent malignancy and improve prognosis.
Results. The article presents a clinical case of CD in a 3.5-year-old boy with a long history of fever, stunted growth, sweating, arthralgia, anemia, high laboratory inflammatory factors, elevated IL-6. There was a complex diagnostic search except for infectious, immunodeficiency, autoimmune conditions. The diagnosis of hyaline-vascular type of CD was confirmed by immunohistochemical examination after lymph node excisional biopsy. Rapid positive dynamics was noted after radical removal of the lymph node conglomerate. At follow-up after 8 months, the patient met criteria for clinical and laboratory remission.
Conclusions. Castleman’s disease should be included in the search algorithm for lymphoproliferative diseases. Determining the role of genetic mutations in interferon regulatory factor (IRF8) is of scientific interest to clarify the etiology of this disease.
Frequency of night eating syndrome and melatonin levels in the urine of adolescents
Authors: Sorokman T. V. , Khlunovska L. Yu.
Published: March 2023

Aim. The aim is to study the frequency of night eating syndrome (NES) and its correlation with melatonin levels in the daily urine of adolescents.
Materials and methods. Primary screening of 486 adolescents (15–18 years) with complaints of eating disorders, overweight, obesity, which included a survey (test “Depressive Disorders in Adolescents”, Night Eating Questionnaire (NEQ), Dutch Eating Behaviour Questionnaire (DEBQ) and anthropometry (BMI) was conducted. In the second stage, a sample of 56 adolescents (11.5 %) who met the NES criteria of DSM-5 (main group) and 50 adolescents who did not have NES (comparison group) was formed. The urine concentration of 6-sulfatoxymelatonin (6-COMT) was determined by enzyme immunoassay (Buhlmann 6-Sulfatoxymelatonin ELISA Kit, Switzerland).
Results. Deficit of body weight had 3 (8.8 %) of adolescent boys, 20 (58.8 %) were overweight, 1 (2.9 %) – obese and only 10 (29.4 %) had the average normative values of body weight; among female adolescents, 1 (4.5 %) – body weight deficit and obesity, 10 (45.5 %) – overweight and average normative indicators. According to the DEBQ, restrictive eating behaviors were identified in 15 (26.8 %) adolescents; in 30 (53.6 %) adolescents – emotional and in 11 (19.6 %) adolescents – external. The mean score of the NEQ was 28.4 ± 2.2 and positively correlated with BMI (r = +0.62, P < 0.05). Participants who exceeded the screening threshold for NES (n = 56, 11.5 %) had increased BMI (P < 0.01), likelihood of overweight/obesity (P = 0.001), consumption of sugary drinks (P < 0.001), daytime sleep less than twice a week (P < 0.01), shorter sleep duration (P < 0.01), high and moderate levels of depression, lower levels of melatonin, which were inversely correlated with the results of the NEQ (r = -0.68, P < 0.05).
Conclusions. The prevalence of NES among teenagers was 11.5 %. Among the types of eating behavior, the most common was the emotional type (53.6 %). Adolescents with NES had a significantly higher total depression score (96.7 ± 8.06, P < 0.001) and a lower level of 6-COMT (22.89 ± 3.44, P < 0.001), which was inversely correlated with the degree of NES (r = -0.68, P < 0.05), BMI (r = -0.74; P < 0.01) and depression level (r = -0.65; P < 0.01).
Results of surgical treatment of distal biceps tendon ruptures
Authors: Lisunov M. S. , Holovakha M. L. , Kozhеmiaka M. O.
Published: March 2023

Rupture of the distal biceps tendon is an injury that most often affects men of working age, so the time and quality of rehabilitation is of great socio-economic importance. Conservative treatment in most cases is impractical, as it leads to a significant increase in treatment time and period of incapacity and does not provide a satisfactory recovery of functions. The main problems of surgical treatment of the distal biceps tendon rupture of the shoulder are considered in the article. Today, there are many methods of surgical treatment, including anchor fixation to the hump of the radial bone; fixation of the distal biceps tendon by using an oval-shaped cortical button fixator, etc. The article presents the main methods of treatment, their advantages and disadvantages.
The aim of the study. To improve the results of surgical treatment of distal biceps brachii tendon rupture by reducing the recovery time and reducing the proportion of complications using a modified technique of button fixation.
Materials and methods. The study was performed by retrospective analysis of the surgical treatment results of 35 patients with fresh rupture of the distal biceps tendon, who were divided into two groups – operated with anchor fixator (n = 15) and cortical button fixator (n = 20). Functional outcomes were assessed by the DASH scale in 3 days, 2 weeks, 6 weeks and 3 months after the intervention; pain intensity was measured by the Visual Analogue Scale (VAS) after 3 days and 2 weeks at rest, after 6 weeks and 3 months – during exercise; the time of surgery was evaluated.
Results. There was a statistically significant improvement in the DASH score at 6 weeks and 3 months after intervention in the cortical fixator group (P = 0.008 and P = 0.003, respectively). Cortical fixation surgery required less surgical time (P = 0.0016) and was accompanied by less pain in the early postoperative period (P = 0.0015).
Conclusions. Surgical intervention with the proposed method takes less operating time, requires a shorter period of immobilization, is accompanied by lower risks for loss of the retainer stability. Features of the proposed intervention technique avoid heterotopic ossification. Early onset of active movements can accelerate the functional restoration of the injured limb. Surgical intervention with the proposed method requires less surgical access, accompanied by lower pain intensity in the early postoperative period.
The association between the skeletal muscle state, lipid metabolism disorders and the development of insulin resistance in children with type 1 diabetes mellitus
Authors: Lezhenko H. O. , Pashkova O. Ye. , Chudova N. I.
Published: March 2023

The aim of the study. To establish a possible association between the skeletal muscles state, changes in lipid metabolism and the development of insulin resistance in children with type I diabetes mellitus.
Materials and methods. 98 children with type 1 diabetes, aged from 11 to 17 years, were examined. Children were divided into 3 groups depending on the state of skeletal muscles: the first group – 22 children without disorders of the muscular system; the second group – 42 children with dynapenia; the third group – 34 patients with diabetic myopathy. The control group – 30 conditionally healthy children. The groups were representative by age, sex, and body mass index.
Children were subjected to examinations of skeletal muscle mass and fat mass, followed by calculation of the skeletal muscle index and body fat percentage, sonomyography of the anterior group of thigh muscles with their thickness determination, measurements of the degree and coefficient of muscle hypotrophy, fasting blood glucose level, serum cholesterol, triglycerides and triglyceride-glucose (TyG) index. Insulin resistance was diagnosed when the TyG index was higher than 4.33 c. u.
Results. It was found that the development of diabetic myopathy, in addition to a decrease in muscle mass, was characterized by a redistribution of the body component composition due an increase in the fat mass proportion. These changes were accompanied by a disturbance of lipid metabolism in the form of increase in serum cholesterol level, triglycerides and TyG index, which was 4.33 c. u. higher in 32.4 % of children with diabetic myopathy, and in 9.5 % of children with dynapenia, while among patients with normal state of the muscular system, the TyG index exceeded the threshold value in no case. Comparison of clinical and laboratory indicators depending on the TyG index level found an increase in the fat mass proportion, a violation of glycemic control, an increase in the daily dose of insulin, appearance of combined hyperlipidemia and the dawn phenomenon in children with an indicator that was higher than 4.33 c. u. All these were indicative of the insulin resistance development.
Conclusions. Skeletal muscle dysfunction in children with type 1 diabetes is a causal risk factor for the development of insulin resistance, a sensitive marker of which is the TyG index. The simplicity of calculating this indicator allows it to be used in daily clinical practice.
Platelet and coagulation hemostasis status in patients with atrial fibrillation depending on warfarin dosing method
Authors: Kolesnyk M. Yu. , Mykhailovskyi Ya. M.
Published: March 2023

The aim. To evaluate indicators of induced platelet aggregation and D-dimer level in patients with atrial fibrillation (AF) depending on the method of warfarin (WF) dosing.
Materials and methods. The study involved 110 patients with AF (mean age 68.72 ± 0.79; men – 57, women – 53). Patients with AF were divided into two groups: the main group – 50 patients with AF and genotype-guided dosing method, the control group – 60 patients with AF and traditional dosing method. CYP2C9, CYP4F2, VKORC1 genetic polymorphisms were determined using multiplex real time polymerase chain reaction, D-dimer concentration – by the method of solid-phase enzyme immunoassay; ADP- and epinephrine-induced aggregation indicators – by the method of G. Born.
Results. The percentage (by 24 %), time (by 3 min 6 s) and rate in 30 s (by 19.5 %/min) of ADP-induced platelet aggregation were significantly lower in patients with AF and genotype-guided WF dosing method. D-dimer concentration in patients of the main and control groups did not differ significantly. However, significantly fewer patients with elevated D-dimer values were registered in the group with genotype-guided WF dosing method compared to the group with traditional dosing method: 0 (0.00 %) vs. 7 (11.67 %) at 500 ng FEU/ml cut-off (χ2 = 4.43, P < 0.05), 1 (2.00 %) vs. 9 (15.00 %) at 390 ng FEU/ml cut-off (χ2 = 4.16, P < 0.05), 0 (0.00 %) vs. 7 (11.67 %) at age-adjusted cut-off (χ2 = 4.43, P < 0.05).
Conclusions. The obtained results may indicate a potentially lower risk of thrombotic events in patients with AF and genotype-guided WF dosing method compared to the group with traditional dosing method, which confirms the benefit of the widespread use of the pharmacogenetic testing in clinical practice.
Bleeding after endoscopic intervention for the major duodenal papilla (a literature review)
Authors: Syvolap D. V.
Published: March 2023

Endoscopic biliary sphincterotomy (EST) is the cornerstone of endoscopic retrograde cholangiopancreatography (ERCP), and bleeding is one of the most common complications after performing EST. The frequency of bleeding after EST varies greatly from 1.0 % to 48.0 %. Clinically, bleeding can range from minor to life-threatening.
The aim of the work was to find out the frequency and risk factors for immediate, delayed and recurrent bleeding after EST, ways of prevention and the most effective methods of treatment for this complication based on the meta-analysis results of recent years.
Conclusions. Bleeding after endoscopic papillosphincterotomy is a common complication with a mortality rate of 1.2–9.0 %. Independent risk factors are liver cirrhosis, duodenal ulcer, end-stage renal failure, hemodialysis, duration of the procedure, prior use of antiplatelet drugs, especially in patients with a low level of platelets (<100,000/μL), and elderly individuals (>80 years). The risk of bleeding after EST does not depend on the size of papillectomy, and the preventive use of proton pump inhibitors does not reduce the risk of bleeding after EST.
The advantages of endoscopic papillary balloon dilatation in reducing the risk of bleeding in patients with liver cirrhosis and in individuals on hemodialysis have been proven. The use of stents (FC-SEMS) is recognized as an effective hemostatic approach to refractory bleeding after EST but is limited in using due to the high cost and additional stent removal procedure. Endoscopic application of peptide hemostatic gel is considered as a third-line hemostatic strategy for bleeding after performing EST.
The role and place of transanal endoscopic resections in rectal cancer
Authors: Nikitenko R. P. , Zaporozhan V. M. , Vorotyntseva K. O. , Koichev Ye. A.
Published: March 2023

The aim of the work is to improve the algorithm of intraoperative diagnosis of rectal cancer metastasis in order to optimize surgical intervention and reduce the number of intraoperative and postoperative complications.
Materials and methods. 184 operated patients with rectal cancer (RC) were divided into 2 groups: group 1 – patients with stage I RC (T1–2N0M0), and group 2 – stage II RC (T3N0M0), who underwent intraoperative detection and examination of sentinel lymph nodes. The volume and surgical approach depended on the stage and the presence of metastases (MTS).
The average period of postoperative observation was 12–60 months, taking into account early (purulent-septic complications, bleeding, intestinal perforation) and late (recurrent rectal cancer) complications.
Results. The patients of group 1 had no MTS lesions of the sentinel lymph nodes, the surgical intervention was limited to transanal microsurgery due to this fact. Among the complications were the following: bleeding – 2.2 %; intraoperative perforation of the intestinal wall – 5.6 %. No purulent-septic cases, no recurrences of rectal cancer were detected.
In group 2, 36 (38.3 %) out of 94 patients had MTS detected intraoperatively in the sentinel lymph nodes which required a low anterior rectal resection with total mesorectumectomy. Among the complications was bleeding – 6.3 %. No intraoperative perforations of the intestinal wall and no purulent-septic complications were detected. Recurrence of rectal cancer was detected in 12 (12.8 %) patients.
Conclusions. Performing transanal endoscopic resections in patients with stage I RC and especially stage II RC is possible only under the conditions of mandatory intraoperative staining and urgent histological examination of the sentinel lymph nodes. The extent of the surgical intervention is determined on the operating table based on urgent histological examination results. When MTS lesions of the mesorectal sentinel lymph nodes are detected, the operation should be continued with mandatory mesorectumectomy.
Development and Validation of the General Learning Motivation Regulation Scale for Chinese High Middle School Students
Authors: Li Li , Fan Anhua
Published: March 2023

Motivation regulation has a profound effect on the students’ learning and associated achievement. Yet, to date, there is a lack of a brief and valid approach for systematically assessing the regu­lation of learning motivation from the perspective of psychometrics, especially for the high middle school students. This study develops a general scale for quantitatively assessing the learning motiva­tion regulation of high middle students, based on the combination of literature analysis and open‑ended interviews in china General Learning Motivation Regulation Scale for Chinese High Middle School Students (GLMR‑CHMSS). A total of 2,304 questionna­ires of high middle school students were included for item analysis and exploratory factor analysis, and another 2,304 questionnaires of high middle school students were subjected to confirmatory fac­tor analyses and a validation and reliability test. The scale con­sisted of 24‑items that can be divided into four factors: intrinsic motivation regulation, extrinsic motivation regulation, volitional behavioural regulation, and self‑efficacy regulation. As indica­ted by the confirmatory factor analysis with the control group, the four‑factor structure model of the GLMR‑CHMSS fitted well (χ2 /df=7.839, RMSEA=0.054, CFI=0.918, TLI=0.908). In ad­ dition, using academic achievement as the empirical validity crite­rion, the scores of each factor of GLMR‑CHMSS and the scale sco­re were significantly correlated with academic achievement were the reliability indicators. This study show cases a novel and va­lid tool for mesuring the degree of learning motivation regulation of high middle school students in China.
A relook into the life of Hendrick Hamel and various editions of “Hamel’s Journal”
Authors: Goh Cleo
Published: March 2023

It is undisputed that Hamel is known in Korea’s history as a historical character who first introduced Joseon to the West in the 17th century. Prior to the release of Hamel’s Journal, the West had never heard of a country named Joseon. Furthermore, Hamel’s Journal also was significant as one of the only sources of information the West had of Joseon up till the 19th century. However, there are still misunderstandings surrounding the historical significance of Hamel in Korea’s history, and additionally, the impact of Hamel’s Journal in the West is not as well-studied despite having played such an important role. Therefore, this paper aims to first look into the historical significance of Hamel within Korea’s history and resolve the misunderstandings surrounding it. Also, the impact of Hamel’s Journal in the West will be discussed and what its role was in shaping the West’s perspective of Joseon from the 17th century.
Status prawny kobiet w wielkich kodyfikacjach cywilnych XIX wieku
Authors: Materniak-Pawłowska Małgorzata
Published: March 2023

Modern civil law’s roots can be traced back to the 19th century, when its basic institutions were comprehensively regulated in three civil codes: the French Civil Code of 1804, known since 1807 as the Napoleonic Code, the Austrian Allgemeines Burgerliches Gesetzbuch (ABGB) of 1811 and the German Burgerliches Gesetzbuch (BGB) of 1896–1900. In the literature, these codes are commonly referred to as the Great Civil Codifications, as they have been influential in shaping European civil law doctrine from their inception to the present day. Although they were drafted under different political conditions (the French and Austrian Codes originated in 18th-century philosophy of natural law, with its individualistic treatment of private law subjects, while the German Code resulted from the triumph of positivism in the second half of the 19th century), and their original content was subject to far-reaching revisions over the years, their invariable merit lay in creating a legal framework guaranteeing the inviolability of individual rights, based on respect for the individual’s fundamental subjective rights under civil law and respect for the autonomy of the will in their implementation. These rights included: the equality and universality of civil rights; the treatment of marriage as a civil contract; the guarantee of the inviolability of private property; the freedom to shape civil law relations by contract; the autonomy of the will of the individual in disposing his or her succession rights. Yet these rights were accompanied by a whole range of limitations and exclusions, particularly for women, whose legal position in terms of civil rights vis-à-vis men was far from the equality and universality of civil law subjects as declared in each of the aforementioned codes. This handicap was only to be remedied in the century that followed.