bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Pharmacokinetic Evaluation of a Bioavailable Curcumin Formulation Curene® with Curcumin Formulation Containing Turmeric Volatile Oil and Standard Curcuminoids 95% in Healthy Human Subjects
Authors: Panda Sanjib Kumar , - Somashekara , Parachur Vivek A. , Mohanty Nilima , Swain Tathastu , Sahu Sailaja
Published: July 2019

Background: Curcumin, a major active component of turmeric, which is one of the most studied botanicals for its numerous health benefits and higher safety profile. In spite of its potent clinical health benefits, its applications are circumscribed due to its poor bioavailability. The current study was carried out to compare the oral bioavailbility of newly developed bioavailable curcumin formulation Curene® with Curcumin formulation containing turmeric volatile oil (CP-01) and Standard Curcuminoids 95% in healthy human volunteers.Methods: In this current open-label, randomized, three treatments, single oral dose, single period, parallel, comparative pharmacokinetics study, 12 healthy male volunteers participated. The test product Curene® (T), reference products CP-01(Reference treatment-R1) and Standard Curcuminoids 95% (Reference treatment-R2) were orally administrated as a single dose of 3 grams per subject. Plasma samples were withdrawn from each subject at predetermined timepoints and samples were analyzed by LC-MS/MS. Results: Based on the pharmacokinetics data, the relative bioavailability (Free Curcumin; AUC0-t) of Curene® was found to be ~112.7 times more when compared to the standard Curcuminoids (R2).Conclusion: The oral bioavailability of Curene® was found to be significantly higher compared to CP-01and Standard Curcuminoids (95%) furthermore, it was also found to be safe in healthy human subjects under the study conditions.
Effects of probiotics and synbiotic on lipid profiles in adults at risk of type 2 diabetes: A double-blind randomized controlled clinical trial
Authors: Kassaian Nazila , Feizi Awat , Aminorroaya Ashraf , Ebrahimi Maryam Tajabadi , Norouzi Atsa , Amini Masoud
Published: July 2019

Background: The use of probiotics and/or prebiotics as an effective means of regulating gut microbiota may have a beneficial effect on metabolic disorders.Aims: This study was designed to assess the ability of probiotics and synbiotic to modify lipid profiles in subjects with prediabetes who are at risk of diabetes and cardiovascular diseases.Methods: In a randomized double-blind placebo-controlled clinical trial, 120 pre-diabetic adults aged 35-70 years from the first-degree family of type 2 diabetic patients were recruited and randomly equally assigned to consume 6 g/d either probiotic or synbiotic or placebo supplements for 6 months. The probiotics used were Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium lactis, and Bifidobacterium longum. Food record, physical activity, anthropometric measures and lipid profiles were assessed repeatedly at baseline, and 3- and 6-month supplementation.Results: Probiotics and synbiotic were effective in reduction of serum triglycerides after 6 months of intervention (SMD=- 10.6 and -9.4 respectively). Compared with the placebo, synbiotic resulted in a significant reduction in serum triglyceride levels (MD±SE: -9.4 ± 6.6 mg/dl vs. +13.2±6.8 mg/dl, p=0.02). Serum total-, LDL-, and HDL-cholesterol were statistically unaffected by probiotic or synbiotic.Conclusion: The results of this study showed that supplementation with probiotic and especially synbiotic could decrease the concentration of triglyceride in prediabetic adults. This finding could warrant future studies to determine the therapeutic and preventive effects of these supplements in individuals at risk of diabetes and cardiovascular diseases.Keywords: probiotic; synbiotic; prediabetes; lipid; lipoprotein
Smart urban governance: An urgent symbiosis?
Authors: Jiang Huaxiong , Geertman Stan , Witte Patrick
Published: July 2019

Over the past decade, two dominant perspectives prevail on the governance of smart cities. From a public administration perspective, ‘smart governance’ emphasizes the importance of technology-based tools in transforming government institutions. From an urban planning perspective, the governance of smart cities focuses on the institution interaction with spatial challenges. Within this backdrop, these perspectives can learn from each other to arrive at new transformative smart governance approaches. This paper proposes a specific urban planning perspective on smart governance, labeled as ‘smart urban governance’. It is aiming specifically at the transformative governance of the socio-spatial context of urban challenges associated to smart cities via technological innovations and opening up new possibilities for city transformation. To this end, the meaning of smart urban governance is conceptualized from three dimensions: purposes, components and contexts. Based on a systematic literature review, these three dimensions are integrated into one holistic framework. A case illustration was applied to demonstrate the use and advantages of this framework. From this, this paper concludes that smart urban governance, by explicitly taking into account the specific socio-spatial context, can improve our understanding of the urban challenges associated to smart cities and contribute to its appropriate and ‘smart’ governance.
Anthocyanins in processed red raspberries on the US market,
Authors: Wu Xianli , Sun Jianghao , Ahuja Jaspreet , Haytowitz David B. , Chen Pei , Burton-Freeman Britt , Pehrsson Pamela R.
Published: July 2019

BACKGROUND:

Red raspberries contain high concentrations of anthocyanins (ACNs). Consumption of red raspberries has steadily increased in the US because of their potential health effects. Processed red raspberry products are widely used in commercial applications, but their ACN contents are largely unknown.

OBJECTIVE:

Types of ACNs and their contents in common processed red raspberries (frozen, juice concentrate and puree) on the US market were investigated.

METHOD:

ACN were analyzed and quantified in thirty-four nationally representative processed red raspberry samples by HPLC-MS.

RESULTS:

Seven cyanidin or pelargonidin glycosides were detected and quantified. Each individual samples contained 4 to 5 of them. Cyanidin-3- O-sophoroside and cyanidin-3- O-glucoside were found to be the major ACNs in all samples, while the minor ACNs varied among different samples. Total ACN contents ranged from 13.88±1.21 to 38.43±2.75 mg/100 g for frozen red raspberries, 30.96±5.34 to 65.29±3.37 mg/100 g for red raspberry juice concentrates, and 10.89±0.94 to 27.11±1.15 mg/100 g for red raspberry puree samples.

CONCLUSION:

The types of ACNs varied slightly but the contents varied considerably between different samples. The sources (national brand vs. store brand, domestic or imported) and processing method (seeded or seedless) did not appear to be major influential factors when multiple samples were included in the comparison.
Time course of blueberry ingestion on measures of arterial stiffness and blood pressure
Authors: McAnulty Lisa S. , Collier Scott R. , Pike Julieanne , Thompson Kyle L. , McAnulty Steven R.
Published: July 2019

BACKGROUND:

Blueberries possess anthocyanins which exert cardiovascular benefits but little is known about the timeframe of these benefits.

OBJECTIVES:

Examine effects of blueberry (BB) or placebo (PL) on variables of blood pressure (BP), augmentation index (AIx), and pulse wave velocity (cPWV) each week for three weeks for chronic assessment and within 1 h and 2 h to assess acute effects in sedentary individuals.

METHODS:

Participants (N = 22), 40 to 70 years old were randomized into BB ( n = 10) or PL ( n = 12). Baseline values were obtained, participants consumed 38 g BB or PL/d for three weeks, and BP, AIx, and cPWV were measured weekly. At the end of week three, 38 g of BB or PL were ingested and acute measures taken at one and two hours post-consumption.

RESULTS:

Chronic and acute ingestion resulted in significant Treatment-Time Interaction for systolic BP (SBP) ( p = 0.030 and p = 0.017, respectively) with BB group being lower. Diastolic pressures were not affected. Chronic and acute Time ( p = 0.029 and p = 0.021, respectively), but not Treatment or Interaction, effects existed for AIx. Acute Time effects existed for cPWV ( p = 0.020) but not for Treatment or Interaction.

CONCLUSIONS:

Change in SBP was not mediated by vessel distensibility but was likely due to an unknown physiologic factor not examined.
Hubungan Tingkat Kecemasan dan Nilai Objective Structure Clinical Examination (OSCE) Blok Mahasiswa Kedokteran
Authors: Novitasari Andra , Lahdji Aisyah
Published: July 2019

Keberhasilan mahasiswa dalam proses pembelajaran tampak dari prestasi belajarnya. Prestasi belajar secara tidak langsung dipengaruhi oleh gangguan perasaan seperti kecemasan yang dirasakan oleh individu. Prestasi belajar mencakup tiga aspek kemampuan yaitu kognitif, afektif dan psikomotor. Salah satu bentuk prestasi belajar yang lengkap menilai ketiga aspek tersebut adalah Objective Structural Clinical Examination (OSCE). Pada pendidikan kedokteran, OSCE dapat dilakukan secara rutin sesuai dengan tema proses pembelajaran melalui kegiatan OSCE Blok. Tujuan penelitian adalah untuk mengetahui hubungan tingkat kecemasan dalam menghadapi OSCE dengan nilai OSCE Blok mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Semarang. Penelitian ini merupakan jenis penelitian analitik assosiatif dengan pendekatan cross sectional. Populasi penelitian adalah mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Semarang tahap sarjana tahun ajaran 2018/2019 yang melaksanakan OSCE Blok. Pengambilan sampel menggunakan metode total sampling. Test Anxiety Questionnaire dari Nist dan Diehl digunakan untuk mengukur tingkat kecemasan dan nilai OSCE sebagai hasil prestasi belajar mahasiswa. Hasil analisis korelasi person diperoleh hasil sign. (2- tailed) 0.645 >0.05, yang berarti tidak terdapat hubungan yang signifikan antara variabel tingkat kecemasan dan nilai OSCE mahasiswa.
Evaluasi Pencapaian Tujuan Pembelajaran Kuliah Kedokteran Melalui Kuis Online Dalam Kelas
Authors: Purwoko Mitayani
Published: July 2019

Kuliah di fakultas kedokteran saat ini menganut sistem problem based learning dimana materi diberikan dalam sistem modul atau blok. Materi kuliah hanya diberikan dalam 100 menit. Jumlah kuliah bervariasi antara 20-24 kuliah per blok oleh dosen pengampu yang berbeda-beda. Banyak cara yang digunakan untuk mengetahui sejauh mana sasaran pembelajaran kuliah dapat tercapai, salah satunya dengan kuis. Tujuan penelitian ini adalah untuk menilai pencapaian tujuan pembelajaran suatu kuliah melalui permainan. Untuk mencapai tujuan pembelajaran kuliah Central Dogma, dosen menggunakan kuis online pada akhir sesi kuliah hari pertama (T1). Kuis online kemudian diberikan kembali pada hari ketujuh pascates pertama (T2). Skor T1 dan skor T2 kemudian dibandingkan. Hasil uji Wilcoxon signed ranks menunjukkan nilai p=0,493, yang berarti bahwa tidak ada perbedaan skor yang bermakna antara skor T1 dan T2. Skor T2>T1 sebesar 32,9% dan T1=T2 sebesar 30,5%. Simpulan, meskipun tidak ada perbedaan skor yang bermakna, namun persentase skor T2<T1 cukup rendah (36,6%). Mahasiswa juga merasakan hal yang menyenangkan terkait kuis online dalam proses pembelajaran. Saran, penggunaan kuis online atau permainan lainnya perlu semakin sering dipergunakan dalam kuliah untuk meningkatkan pencapaian tujuan pembelajaran.
КОНСОЛІДОВАНІ БЮДЖЕТ ПІВНІЧНОГО РЕГІОНУ В УМОВАХ ЕКОНОМІЧНОЇ КРИЗИ
Authors: Гаджиев Ю. А.
Published: July 2019

One of important tasks of overcoming the crisis and sustainable economic growth of the country and its regions is formation and effective use of financial resources in the budgetary sphere. The purpose of the research is to analyze the formation of income and the direction of expenditures in the context of the economic crisis and offer practical recommendations to ensure the balance and stability of the consolidated budget of the Republic of Komi (RK). The object of the research is the monetary and economic relations of the formation and use of funds of the consolidated budget in order to fulfill its obligations and ensure the economic growth of the region. Methods used of the research are analysis and synthesis, induction and deduction, logical and historical method, scientific abstraction and statistical comparison. The hypothesis of the research is the possibility of ensuring the balance and stability of the consolidated budget of the RK in the long term. The statement of basic materials. The analysis of the dynamics and structure of real revenues and expenses of the consolidated budget of the Republic of Komi in 2013-2017. The reasons for the fall and the growth of real incomes and expenses, changes of their structure and especially sharp increase of the debt load of the budget are revealed. Level of imbalance of the budget is shown and recommendations on ensuring balance of the consolidated budget of the region are defined. Originality and practical significance of the research is the fact that the balance and stability of the consolidated budget of the region is considered as the main tool for ensuring sustainable economic growth and improving the welfare of the population of the region. Conclusions of the research are the possibility of restoring the balance and stability of the consolidated budget of the Republic of Komi in the crisiscondotions by increasing the volume of tax revenues, especially property tax, reducing the debt service outlays – reducing the amount of accumulated public and municipal debt.
ДОКУМЕНТУВАННЯ РЕЗУЛЬТАТІВ ДІЯЛЬНОСТІ ВНУТРІШНЬОГО АУДИТУ БАНКУ
Authors: Долінська О. М.
Published: July 2019

The article deals with the need to document of an assurance engagement of internal auditors of the bank and the organization of this process by the internal audit department. The purpose of the research is to analyze the latest requirements for documenting the results of the internal audit work in accordance with the International Standards for the Professional Practice of Internal Auditing. The object of research – the documents of an assurance engagement of internal auditors. The methods used of the research: analysis and synthesis, induction, methods of scientific knowledge. The hypothesis of research: a professional judgment is formed on documented provides receiving audit evidence for individuals who use an assessment of the activities of the internal audit department for specific purposes. The statement of basic material: the results of the analysis identify the documents used by the internal auditor to substantiate the findings of the audit findings. On the basis of the organization of the documentation process, the documents that selected to the implementation of an assurance engagement of internal auditors at each stage of the internal audit are selected and grouped. The originality and practical significance of the research is to develop of documents that will improve the organization and execution of an assurance engagement of internal auditors and will provide an evidence base for the results in the audit report. Conclusions of the research. Established that the implementation of documentation provides receiving audit evidence for the development of recommendations for decrease of risk and risk management, improving the system of internal control of banking activities and promoting the improvement of governance.
ФІНАНСОВЕ ЗАБЕЗПЕЧЕННЯ РОЗВИТКУ ПІДПРИЄМСТВ АПК: ТЕНДЕНЦІЇ, ПРОБЛЕМИ, ПРІОРИТЕТИ
Authors: Костирко Л. А. , Соломатіна Т. В.
Published: July 2019

The article is devoted to research of problems and substantiation of priority directions of financial support of development of agrarian enterprises. The purpose of the research is to analyze the current state, tendencies for identifying problems and priorities of financial support for the development of agribusiness enterprises. The object of research - the tools of financial support for the development of agrarian enterprises. Methods used in the research: logical-content, methods of scientific knowledge, induction, analysis and synthesis. The hypothesis of research: priority sources of financing for the development of enterprises of agroindustrial complex: state support, lending, investment, mergers / acquisitions, stock instruments. The statement of the basic material: according to the results of the analysis of the state and trends of development of enterprises of the agricultural sector, the priority directions of its financial support were determined. Based on the study of world experience of resource subsidy models, the possibility of adapting key support models for separate segments of the agrarian enterprises activity, taking into account the peculiarities of their management, is shown. At this stage, the reform of the agrarian sector requires state support in the form of introducing privileges for innovative development and lending. Financing of innovations at domestic agrarian enterprises is usually carried out at its own expense in small volumes. The originality and practical significance of the research is to justify the tools for improving financial support for the development of agrarian enterprises, which combine tax incentives for innovation, leasing programs, innovation-oriented loans, venture financing, stock mechanisms, land mortgages, market instruments. Conclusions of the research: improving financial support will help to improve the system of state support by stimulating the development of particularly significant segments of the agro-sector for the region and the country as a whole.
ІНВЕСТИЦІЇ ЯК КЛЮЧОВИЙ ФАКТОР ПІДВИЩЕННЯ КОНКУРЕНТОСПРОМОЖНОСТІ АПК ПІВНІЧНОГО РЕГІОНУ
Authors: Мустафаев А. А.
Published: July 2019

Activation of the investment activity of the agro-industrial complex of the Komi Republic is a key factor in increasing the competitiveness of its industries and enterprises. The purpose of the research is to reveal the role and value of investments in ensuring the competitiveness of the agro-industrial complex. The subject of the research is the identification of various aspects of the object under investigation, associated with sectoral properties, territorial features and natural-economic conditions of management. The methods used in the research: analysis and synthesis, systems approach, methods of operations research, generalization, historical and logical method, scientific abstractions, tabular methods. The hypothesis of the research is the formation of some arguments to increase the scale of the introduction of innovative components, increase the competitiveness of the agro-industrial complex for the future. The statement of the basic main material. The main focus is on providing agricultural enterprises with high-quality tangible and intangible assets.During the years of reforms in the agricultural sector of the region, normal conditions for the effective functioning of enterprises were not created. The reasons for this were the lack of financial resources and the incomplete autonomy of doing business, as well as the low level of competitiveness of the products produced, the lack of competitive advantages. The lack of incentives to produce high-quality products and the excessively weak development of financial and investment relations led to an unequal inter-sectoral distribution of monetary and material and technical resources of the regional agro-industrial complex. The originality and practical significance of the research lies in the fact that, based on production and market positions, the categories of "investment" and "competitiveness" of the agro-industrial complex should be considered both in a single context and separately. The conclusions of research are that the larger and better resource potential agricultural enterprises have, the easier they are able to ensure high competitiveness.
ІННОВАЦІЙНІ ІНСТРУМЕНТИ РОЗВИТКУ РЕГІОНАЛЬНОГО ТУРИЗМУ
Authors: Зеленко О. О. , Перепелиця Ю. Р.
Published: July 2019

Ukraine, having lost its positive image as a country safe for traveling, faced the problem of its restoration. It is necessary to start from the own population, which instead of native regions of permanent residence preferring to have vacation on abroad resorts. Therefore, the search of innovative tools for the restoration of regional tourism is an urgent problem for most regions of Ukraine. The purpose of the research – definition of modern problems and systematization of relevant innovative tools for the development of regional tourism, taking into account the existing conditions for the functioning of the national tourism industry. The object of the research: theoretical and applied aspects concerning application of relative innovative tools for the development of tourism industry at the regional level. The methods of the research: systematic approach, structural-logical and statistical analysis, synthesis and generalization. The hypothesis of the research: envisages the use of the approach by which the development of tourism at the regional level should be fully harmonized with the overall strategy of the territory and state development strategy taking into account the needs of all stakeholders. The statement of basic materials. Overview of previous research and current trends of national tourism industry development in the context of certain territories and regions has allowed to identify six main problems and three groups of topical innovative tools for the development of regional tourism, among them: the introduction of the social dialogue concept and the formation of social partnership on its basis; branding of the area as an effective tool for managing the image of the territory; using technology "product placement" and IT innovations. The originality and practical significance of the research: the presented proposals are especially relevant for the old industrial regions and separated depressed territories, for which the development of the tourism industry on the basis of its own tourist flows will overcome the systemic socio-economic crisis. Conclusions. The proposed innovative tourism development tools at the regional level are not absolute innovations for Ukraine, but their distribution should have a lasting character for all without exception areas, which will solve most of the identified problems.
КОРЕКТУВАННЯ ІНДИКАТОРІВ РЕСУРСНОЇ ЕФЕКТИВНОСТІ НА ПРИКЛАДІ ОСОБЛИВО ОХОРОНЮВАНИХ ПРИРОДНИХ ОБ'ЄКТІВ
Authors: Тихонова Т. В. , Щенявский В. А.
Published: July 2019

One of the integral methods for assessing resource efficiency is the adjustment of net savings, which includes indicators reflecting consumption of fixed capital, depreciation, education costs, environmental protection costs and the value of specially protected natural areas (PAs), depletion of natural capital and damage to public health from habitat pollution. The purpose of the research is to assess the contribution of protected areas based on the value of their ecosystem services, taking into account the consideration of regional destinations of tourist and recreational services. The object of the research is the most significant specially protected natural objects of the Komi Republic. Methodological basis. To determine the economic value of regulating and cultural services, the methods of market indirect assessment, compensatory costs and travel expenses were used. Evaluation of the effectiveness of the tourist destination on recreational PAs resources was based on a combination of the target approach, including indicators of the contribution of the destination to the GRP, the growth of tourist flow, value added and an assessment of the volume of network interaction of tourism subjects. The hypothesis was the assumption of reducing the contribution of the value of protected areas to the region's GRP over a long study period, which means low efficiency in the use of natural capital. The statement of basic materials. Received the contribution of protected areas to gross savings, GRP for the period 2000-2018. An approach to assessing the tourist and recreational services of protected areas has been implemented, taking into account the implementation of a regional / local destination, integrated logistics, tourism resources and products aimed at reducing transaction costs, increasing production capacity, volume and quality of investment, reducing losses in the value chain and distribution, improving the quality of the tourist product, reducing the cost of improving and developing new products. The quality of the functioning of the food chain of destination has been determined. The originality of the research lies in the comprehensive consideration of protected areas as a resource for the regional economy. Conclusion of the research. The analysis carried out and the calculations carried out will make it possible in the future to determine the reserves and ways to achieve eco-efficiency in the use of the natural capital of the territories of special protection and development of tourism in PAs.
ПИТАННЯ ДЕРЖАВНОГО УПРАВЛІННЯ ВІДНОСНО ПІДВИЩЕННЯ ЙОГО ЕФЕКТИВНОСТІ
Authors: Asadullina N. R.
Published: July 2019

In the article there considered the issues of theoretical underlying reasons of public administration as an element of management system of society, the issues of combination of self-management and public management, in dependence of forms of participation of the state in economy from head institutions. The purpose of the research is the mapping of the main directions of public management and administration, in order to find ways to improve its efficiency and effec-tiveness. The object of research – the process of public administration in the country of state-owned objects, as well as ways to improve its efficiency. The methods used in the research – logical, comparative, analytical, scientific and methodological. The hypothesis of the research is the ways to improve the efficiency of public administration depend on the qualifications of management personnel and feedback from the local population. The statement of basic materials. The economic conversions which carried out in Uzbekistan have beck directed to dismantling of the institutes resisting to the market, and active formation of the new institutional struc-tures inherent in preferentially market public systems. Gradualness and sequence of the re-formatory steps excluding shock components for economy and population and providing a necessary social insurance of transformational risks are the feature of transformational model of Uzbekistan. The originality and practical significance of the research. The choice of model of public admin-istration in economy is inevitably connected by geopolitical priorities and ideas of the place of the country in the modern world. It means that exert impact on institutes of management and an assessment of management efficiency and political factors which are in turn subdivided on internal political are, first of all, support by the population of the idea of the state independence. Conclusions of the research. Further improvement of public admin-istration assumes improvement of legal base of administrative activity (from a position of in-terests of public servants), necessary guaran-tees and incentives, standardization of their activity as most complex, responsible and skilled work, and maximum informatization of administrative decisions. Such approach as-sumes formation of special legislation on pub-lic service, development of the quality stand-ards of state services, electronic forms of low-cost and transparent forms of interaction with economic entities and citizens.
PENGELOLAAN PEMBELAJARAN MENGHAFAL AYAT AL-QUR’AN SECARA CEPAT DENGAN STRATEGI PERMAINAN CROSSWORD PUZZLE
Authors: Khardi Syarifuddin
Published: July 2019

One of the learning strategies that can be applied to the subjects of Islamic Education and Budi Pekerti is the strategy of crossword puzzle. This strategy allows learners to learn optimally, because this strategy is one model of active learning, fun and resembles the play of words through composing verses of mufradat into a whole verse. The purpose of this material is as an answer to the teachers so that learners more quickly memorize the verses of the Qur'an on the subjects of Islamic Education and Character especially on the aspects of the Qur'an. From the results of the description that the application of learning with crossword puzzle strategy is very helpful for teachers and students in memorizing Qur'anic verses according to the material on aspects of the Qur'an and greatly give positive and significant influence with learning outcomes, the learning model of crossword This puzzle can be used as a teacher model of learning in class.

Keywords. Learning Model, Crossword Puzzle, Learning Result
MENGINTEGRASIKAN MANAJEMEN SUMBER DAYA MANUSIA DI MADRASAH
Authors: Noor Wahyudin
Published: July 2019

Human resource management is part of organizational management that is supposed to focus on human resources. Observing the importance of the role of human resources in the organization of this madrasah, at least is to reconciling the development of the work environment that occurs-especially in the world of Islamic education today, so that madrasah should be able to pay attention to the importance of human resource management programs through the practice of integrating human resources management including human resource planning, recruitment, selection, orientation and placement, training and development, job assessment and compensation into planning, management and control of madrasah organizations related to allocation and human resource development in madrasah

Keywords. Management, Human Resource Development, Madrasah.
MANAJEMEN LABORATORIUM DALAM UPAYA MENINGKATKAN MUTU PEMBELAJARAN
Authors: Nurhadi Arisal
Published: July 2019

This article examines laboratory management in an effort to improve the quality of learning in schools, how to plan, implement, and evaluate laboratory management in schools. Planning of the laboratory in the school by looking at the needs of goods and budget. This planning can be done at the end of each semester by means of coordination meetings between laboratory heads, infrastructure representatives, and principals. Implementation of the laboratory includes procurement, storage, structuring, inventation, use, and maintenance. Procurement is done in accordance with existing needs and adjusted to school budget. Storage is done by making the codes and placed sessuai with place and its usefulness. The arrangement is done according to the encoding per cabinet or shelf or locker or storage warehouse. Inventory is done by taking notes of newly arrived items by giving a code or sticker. Use of laboratory facilities and infrastructure is used in accordance with the needs and usefulness of each item. Maintenance by repairing lightly damaged goods and removal for heavily damaged items. The evaluation of the management of the laboratory in an effort to improve the quality of learning in schools is done by coordination meeting at the end of the year between the head of the laboratory, the vice principal of the facilities and prsasarana, and the principal.

Keywords. Infrastructure Facility, Laboratory, Quality of Learning
EKSISTENSI PENDIDIKAN ISLAM PASCA REFORMASI
Authors: Wasehudin Wasehudin
Published: July 2019

The money crisis is a bitter history for the Indonesian nation, but in the end it can be diverse Law of National Education System Number 20 Year 2003 and Government Regulation Number 55 Year 2007 formally there is general education with Islamic education institute. This was reinforced after the Signing of a Joint Decree (SJD) of five ministers (Ministry of Education and Culture, Ministry of State Apparatus Empowerment and Bureaucracy Reform, Ministry of Home Affairs, Ministry of Finance and Ministry of Religious Affairs) should be a bright signal for the existence of institutional education in Indonesia Islamic education institutions, but unfortunately the fate of this joint decree together with the previous joint decree. Experts agree that education has a very important role in creating human resources as a determinant of the nation's future toward a just, prosperous and prosperous society. After the monetary crisis of 1997, the leaders of the Indonesian nation realized that education is an agent of change for the progress of a nation.
PENINGKATAN KUALITAS PEMBELAJARAN SERTA AKTIFITAS BELAJAR SISWA PADA PELAJARAN PKN MELALUI PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE BERMAIN KOCOK DADU DI SMP NEGERI 5 KOTA SERANG
Authors: Komariah Komariah
Published: July 2019

Teaching and learning activities at school should be interesting and funny, student activities as learning is always enthusiastic in following each subject. But the reality in the field shows another, learning activities that should attract, full of activities, creativity and bright ideas that do not exist, there is only a passive class hanayalah. Teachers are the spearhead in the success of teaching and learning process, therefore teachers are required to be able to innovate and master the various methods in delivering learning meteri that will be conveyed to the students. Lack of variation in the model of learning is one of the factors lazy students in following the teaching and learning process resulting in the level of mastery of student learning. To cultivate the spirit, cheerfulness in learning and not boring required a method of learning such as "shake the dice" as one of the active learning model, is essentially a traditional game with the aim that students in implementing learning is not saturated because this learning invites students to play while learning.

Keywords. Learning Activity, Learning Model, Beat Dice
IMPLEMENTASI PELIBATAN DAN PEMBERDAYAAN DALAM KUALITAS PADA ORGANISASI PELAJAR MADRASAH ALIYAH SWASTA
Authors: Wibowo Akhmad Ari , Supriyanto Achmad , Timan Agus
Published: July 2019

Abstrak. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana implementasi pelibatan dan pemberdayaan dalam kualitas pada IPM di MA Muhammadiyah 1 Malang. Penelitian ini menggunakan paradigma kualitatif dengan metode observasi, wawancara dan dokumen untuk mengetahui implementasi pelibatan dan pemberdayaan dalam kualitas pada lembaga tersebut. Didapatkan bahwa madrasah mengimplementasikan pelibatan dan pemberdayaan dalam kualitas pada organisasi pelajarnya. Proses implementasi dilakukan dengan membentuk budaya organisasi yang baik pada organisasi pelajar melalui empat tahap yaitu (1) menciptakan lingkungan yang mendukung, (2) menentukan target dan mengatasi penghambat, (3) menerapkan dan menggunakan sarana pendukung, (4) menilai, menyesuaikan dan memperbaikinya. Dalam pelaksanaannya, digunakan trial-error-fix sehingga dapat dilakukan evaluasi secara berkelanjutan. Implementasi pelibatan dan pemberdayaan ini dirasa membawa dampak positif pada diri peserta didik dan pada budaya organisasi pelajar tersebut.

Kata Kunci.  Madrasah; Kualitas; Organisasi Siswa Intra Sekolah; Ikatan Pelajar Muhammadiyah; Pelibatan dan Pemberdayaan.
PERAN KURIKULUM KULLIYATUL MU’ALLIMIN AL-ISLAMIYAH (KMI) GONTOR 9 DAN DISIPLIN PONDOK DALAM MENUMBUHKEMBANGKAN KARAKTER SANTRI
Authors: Budi Abdul Mufid Setia , Apud Apud
Published: July 2019

This study aims to describe the curriculum of Kulliyatul Muallimin al-Islamiyyah Gontor and cottage discipline in developing the santri character, which includes: the application of a curriculum developed in the modern Gontor boarding school, the application of cottage discipline during santri living in dormitory environments, and the formation of santri characters as a result of the implementation of the KMI curriculum and cottage discipline. This study is a field research with a qualitative-descriptive approach. The results showed that (1) Kont Gontor 9 curriculum is an integration between the curriculum of scientific competence and character formation that is implemented in the totality of santri's life for 24 hours, (2) Gontor 9 cottage discipline is a standard rule of santri activity while staying in the cottage which includes time discipline, place discipline, activity discipline, self discipline, and (3) KMI curriculum in this case there is a written curriculum and hidden curriculum which acts as a guideline in the process of developing the character of santri through curricular, cochurricular, extracurricular programs designed in 24-hour activities.

Keywords. Kulliyatul Mu'allimin Al-Islamiyah curriculum, discipline, character.
The degree of cumulation of the “Bendamin” drug in the body of white rats
Authors: Varkholiak I. S. , Gutyj B. V.
Published: July 2019

Repeated introduction into the body of an animal of a medicinal substance can lead to its accumulation in the tissues of the body. Therefore, knowledge of the cumulative properties of substances or conditions that may lead to cumulations, are especially important for understanding the pathogenesis of intoxication, because this phenomenon often lies at the basis of acute and chronic poisoning. The purpose of the work was to study the degree of cumulation of the “Bendamin” preparation in the body of white rats. The properties of the cumulative drug were studied in 12 white rats weighing 150–160 g. Rats were divided into 2 groups: control and experimental. To determine the cumulative properties of Bendamin, it was administered to laboratory animals starting at a dose of 0.1 DL50, with a sequential increase in the dose of 1.5 times every 4 days. It was found that the cumulative coefficient of Bendamin was 8.31 units, indicating that the drug does not exhibit cumulative effects. In determining the mass coefficients of the internal organs in the animals of the experimental group, the tendency to increase the weight and liver mass coefficients was determined, respectively, by 5.2 and 5.1%. The weight ratio of the heart of the animals of the experimental group increased by 5.7% relative to the control group. After studying the morphological parameters of blood of rats at 24 days of the experiment for studying the cumulative properties of the “Bendamin” drug, an increase in the number of erythrocytes to 6.13 ± 0.27 T/L, white blood cells to 8.42 ± 0.54 G/L and hemoglobin up to 132.4 ± 2.44 g/l. In the analysis of leukocyte profile in rats, there was a decrease in the number of eosinophils and monocytes, respectively, at 1.1 and 1.3% relative to the control group. The number of lymphocytes in the blood of the experimental group of rats increased by 1.5%, while neutrophils by 0.9% compared to the control. When studying the level of total protein, its small increase was determined by 5.2%. The activity of aminotransferases in the blood serum of experimental rats on the 24th day of the experiment for the study of cumulative properties of the drug also increased by 13 and 8% relative to the control group. Also, creatinine and total bilirubin levels in their rat blood were decreased by 3.1 and 8.8%, respectively.
Application of aflubine in the treatment scheme for pigs with respiratory syndrome
Authors: Rybachuk Zh. V. , Galatyuk O. Ye. , Romanyshyna T. O.
Published: July 2019

The article investigates into changes of clinical parameters and leukograms of pigs with respiratory syndrome in comparison with the use of unprotected antibiotics penicillins (amoxicillin suspension 15%), third generation cephalosporins (ceftracone) and complex therapy (ceftracone in combination with oral administration of aflubin). In pigs, many pathogens (bacteria and viruses) parasitize, which can affect the upper respiratory tract. Failure to observe the rules for the use of antibiotics for the treatment of animals leads to the formation of resistant forms of microorganisms. Therefore, the introduction of treatment regimens that simultaneously have a polyvectoral action and stimulate the functioning of the body systems (as well as the work of homeopathy), allows you to achieve a positive therapeutic effect more quickly. In a private household where pigs are kept fattened, the disease of pigs with respiratory syndrome is registered, mostly in 14–28 days after purchase. In such animals, body temperature increased to 41.0–41.1 degrees Celsius, fever, weakness, lack of appetite, animals buried in the litter, and in the leukoformula, a slight increase (by 4.8% excess of the upper physiological limit) of lymphocytes and a slight decrease in segmental nuclei neutrophils (by a maximum 1.2% below the minimum physiological level). From pigs with respiratory syndrome, on the principle of analogues, formed three groups of 4 animals. For treatment, the first group used emulsion amoxicillin 15% from the rate of 1 cm3/10 kg of body weight of the animal, the second - ceftriaxone (20 mg/kg body weight 2 times a day for 3–5 days), the third – with ceftriaxone aflubin at the expense 10 drops (0.5 cm3/60 kg body weight for 3 days). Pigs eagerly consumed the drug when we took the drug into the syringe and orally, inserting the cannula for the lower lip. Based on randomized controlled trials, the simultaneous use of ceftriaxone intramuscularly and oral administration of Aflubine every 4 hours (during the first day), and subsequently with an interval of 12 hours for 3 days, contributes to complete clinical healing within the first day after commencing the use of drugs and shortens the treatment period pigs in 2 times, than the introduction of only ceftraxone. Oral use of aflubin in pigs administered intramuscularly amoxicillin provided cure for the next 12 hours, manifested by the restoration of appetite. Consequently, administration of aflubine with ceftriaxone and amoxicillin provides a reduction in the duration of pigs’ treatment with respiratory syndrome, which will reduce the use of antibiotics. Therefore, we consider it expedient to introduce into the schemes of this homeopathic remedy treatment in the therapy of pigs with symptoms of the infectious etiology respiratory system.
Acute and subacute toxicity of the drug based on tylosin tartrate
Authors: Patereha I. P. , Kushnir V. I. , Zhyla M. I. , Dubin O. M.
Published: July 2019

The article presents the results of a study of the acute and subacute toxicity of the drug TILOTAR (a water-soluble powder for oral administration) made on the basis of tilmicosin. As a result of the research it was found that the drug “TILOTAR” refers to the 4th class of toxicity, that is, to low-toxic substances. After intragastric administration of the drug to white mice and rats at doses of 2500, 5000, 7500 mg/kg, all animals remained alive. Short-term inhibition was recorded in laboratory animals, which were given the drug at the maximum dose. Further changes in the clinical state of the animals of the experimental groups were not observed. The study of subacute toxicity of the drug “TILOTAR” showed that 14-day administration of a therapeutic dose of the drug leads to a decrease in erythropoiesis, the appearance of old forms of erythrocytes, damage to hepatocytes, the appearance of eosinophils, γ-globulins, a decrease in protein biosynthesis, increased kidney function. The introduction of a 10-fold dose within 14 days reduced the body weight of the rats, leading to abnormalities in the liver and kidneys, and a decrease in the mass of the spleen. An increase in urea blood concentration and a decrease in creatinine may indicate impaired renal function in animals that were given a tenfold dose of the drug, and an increase in the level of α- and γ-globulins against the background of a decrease in body weight of rats indicates an overload of the body’s immune system. In rats of the therapeutic group, homeostasis was maintained by enhancing kidney function, accompanied by a decrease in the number of erythrocytes due to young forms and the appearance of mature erythrocytes with a high level of hemoglobin (MCH), some destruction of hepatocytes (high level of alkaline phosphatase activity) while reducing the amount of albumin, an increase in relative levels of α- and γ-globulins. In the conducted experiments it was established that the macroscopic and microscopic structure of the internal organs of rats, while studying the subacute toxicity of the drug “TILOTAR”, was preserved, no macroscopic changes were revealed. In rats receiving a 10-fold therapeutic dose of the drug for 14 days, focal protein dystrophy of the liver and kidneys was histologically established.
State of the organism of the same year scaly carp infected by Eudiplozoon nipponicum
Authors: Fedorovych O. V. , Gutyj B. V.
Published: July 2019

One of the least studied monogeneses doses, for today, there is diplopic zoonosis of carp. Previously, it was believed that there is only one fish parasitize bothrium – Diplozoon paradoxum. However, in recent years it has been discovered and described already more than 10 species of pathogens of diplozoons, in particular Eudiplozoon nipponicum. Outbreaks of this disease are increasingly beginning to be recorded in fish ponds farms of the western region of Ukraine. Moreover, more often than in others in the amount of this parasite occurs in young fish. In view of the above, the purpose of our research was to investigate the degree of infestation of the same year scaly carp with the mentioned ectoparasite and study the changes that occur in morphological and biochemical composition of blood, intensity of peroxide processes, as well as the state of antioxidant and immune systems in invasive fish. The research was carried out in the garden and fish farms of the State Enterprise “Rybhosp"Galitskyi” (renamed LLC “Rybgosp “Burshtynskyi”) Ivano-Frankivsk region and FG “Dobrotvir fish factory” of Lviv region with the same year scaly carp. Two experiments were selected for the experiment groups of the same yaer of scaly carp (control – non-invasive fish and experimental – invasive with Eudiplozoon nipponicum) in 6 specimens of fish in each group of weights bodies 45–47 g. In experimental fish they were studied their infestation with ectoparasites, as well hematological parameters, protein content of the blood, peroxide intensity processes, the state of antioxidant and immune systems of non-invasive and invasive specimens. During the parasitological examination of both experimental fish farms was detected infestation in scaly carp caused by ectoparasites Epidipalous nipponicum. In May there was a pick of infected the same year scaly carps (2.87 and 3.10 eggs/fish). Infected fish, compared to non-invasive fish, there were significant changes in hematological parameters. In particular, in the blood of parasites affected by fish the number of erythrocytes decreased (P < 0.001), the hemoglobin content (P < 0.001) and hematocrit and increased number of leucocyte (P < 0.001).The infected scaly carp the above-mentioned parasite pressed by the protein-synthesizing function of the organism, as indicated a high (P < 0.001) reduction in total protein, albumin and α-globulins in the blood serum, there is a depression in them humoral links of non-specific resistance and antioxidant system activity protection, and the content of products of peroxide oxidation of lipids in their hepatopancreas significantly increases.