bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Oleuropein, Derived from Olives, in Human Skin Fibroblast Cells: Investigating the Underlying Molecular Mechanisms of Cytotoxicity and Antioxidant and Anti‐Inflammatory Activities
Authors: Asghariazar Vahid , Vahidian Fatemeh , Karimi Arash , Abbaspour-Ravasjani Soheil , Mansoori Behzad , Safarzadeh Elham
Published: August 2024

Oleuropein is the main compound in olives, producing a relatively bitter taste for unprocessed and raw olives. It has been dramatically applied in herbal and traditional medicine and contains several biological functions, anti‐inflammatory effects, antimicrobial characteristics, and anticancer and antioxidant activities. The present study dealt with the cytotoxic effect, reactive oxygen species (ROS) suppressor, and wound‐healing activity of oleuropein on normal skin cells. Oleuropein’s cytotoxic and apoptotic effects were evaluated using MTT, flow cytometry, and DAPI staining. Moreover, oleuropein’s possible free radical scavenging properties were studied through several methods, including the 2, 2‐diphenyl‐1‐picrylhydrazyl (DPPH) and ABTS tests. The scratch assay was performed for wound‐healing features, and qRT‐PCR evaluated the expression of apoptosis‐associated genes. Oleuropein was found to have a cytotoxic effect on skin cells at higher exposure doses. Apoptosis was induced in the flow cytometry histogram of the cells treated with oleuropein. The results also revealed the strong anti‐inflammation and antioxidant effect of oleuropein. They suggested that more studies are necessary to assess the possible pharmacological use of oleuropein to prevent or decrease skin‐related diseases.
Figure 5 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
Authors: Chehade Hussein , Gogoi Radhika , Adzibolosu Nicholas K. , Galoforo Sandra , Fehmi Rouba-Ali , Kheil Mira , Fox Alexandra , Kim Seongho , Rattan Ramandeep , Hou Zhanjun , Morris Robert T. , Matherly Larry H. , Mor Gil , Alvero Ayesha B.
Published: August 2024

The noncanonical Wnt pathway is activated upon loss of BRCA1. A, Model of the noncanonical Wnt signaling pathway. B, ID8 mouse ovarian cancer cells were treated with 100 ng/mL Wnt3A followed by immunofluorescence for F-actin (green). DAPI staining is shown in blue. Red arrows point to F-actin filaments. Images show both green and DAPI channels. C, Biological processes related to filament and microtubule polymerization are differentially regulated in BRCA1mt vs. BRCA2mt and HRwt ovarian tumors. DAPI, 4′,6′-diamidino-2-phenylindole.
Figure 3 from mTORC1-Driven Protein Translation Correlates with Clinical Benefit of Capivasertib within a Genetically Preselected Cohort of PIK3CA-Altered Tumors
Authors: Sobsey Constance A. , Froehlich Bjoern C. , Mitsa Georgia , Ibrahim Sahar , Popp Robert , Zahedi Rene P. , de Bruin Elza C. , Borchers Christoph H. , Batist Gerald
Published: August 2024

Statistical analysis of targeted protein quantitation in capivasertib-sensitive (green) and capivasertib-resistant (red) HR+PIK3CA-altered breast cancer cell lines. A, Schematic of experimental design for phase II of the study. B, Heatmap of protein concentrations quantified by MRM-MS with hierarchical clustering. C, Cell line sensitivity to capivasertib, expressed as IC50 (D) Protein concentrations in capivasertib-sensitive vs. capivasertib-resistant cells (E) PCA (left) and PLS-DA plot (right). F, Top 22 features ranked by VIP scores, presented with the direction of change in capivasertib-resistant vs. capivasertib cell lines as compared to NCB vs. CB patient tumors.
Figure 1 from mTORC1-Driven Protein Translation Correlates with Clinical Benefit of Capivasertib within a Genetically Preselected Cohort of PIK3CA-Altered Tumors
Authors: Sobsey Constance A. , Froehlich Bjoern C. , Mitsa Georgia , Ibrahim Sahar , Popp Robert , Zahedi Rene P. , de Bruin Elza C. , Borchers Christoph H. , Batist Gerald
Published: August 2024

Statistical analysis of targeted and global proteome comparing protein expression in analyzed FFPE tumor tissues from the CB (green) and NCB (red) groups. A, Schematic of experimental design for phase I of the study. B, Results of targeted quantitation by iMALDI-MS. Boxplots of protein concentrations in the CB (green) vs. NCB (red) groups. Each point represents one patient tumor, averaged for multiple slides. P-values are given for a two-tailed t test. C, Heatmap of 50 selected proteins with highest differential expression between groups showing their normalized LFQ abundances across both analyzed batches. n = 23. Arbitrary identifiers are included for the purpose of identifying replicates from the same tumor. D, Volcano plot showing the fold change (log2FC) of all protein expression features vs. P-value (−log10P). E, PCA. Proximity of sample replicates originating from the same patients is indicated with a (dashed yellow line). F, Features ranked by VIP based on their contribution to the discrimination between the CB and NCB groups in the PLS-DA. The arrows on the right of the VIP Feature list show relative expression of that protein in the NCB group vs. the CB group.
Data from mTORC1-Driven Protein Translation Correlates with Clinical Benefit of Capivasertib within a Genetically Preselected Cohort of PIK3CA-Altered Tumors
Authors: Sobsey Constance A. , Froehlich Bjoern C. , Mitsa Georgia , Ibrahim Sahar , Popp Robert , Zahedi Rene P. , de Bruin Elza C. , Borchers Christoph H. , Batist Gerald
Published: August 2024

Abstract
Capivasertib is a potent selective inhibitor of AKT. It was recently FDA approved in combination with fulvestrant to treat HR+, HER2-negative breast cancers with certain genetic alteration(s) activating the PI3K pathway. In phase I trials, heavily pretreated patients with tumors selected for activating PI3K pathway mutations treated with capivasertib monotherapy demonstrated objective response rates of <30%. We investigated the proteomic profile associated with capivasertib response in genetically preselected patients and cancer cell lines. We analyzed samples from 16 PIK3CA-mutated patient tumors collected prior to capivasertib monotherapy in the phase I trial. PI3K pathway proteins were precisely quantified with immuno-Matrix-Assisted Laser Desorption/Ionization-mass spectrometry (iMALDI-MS). Global proteomic profiles were also obtained. Patients were classified according to response to capivasertib monotherapy: “clinical benefit (CB)” (≥12 weeks without progression, n = 7) or “no clinical benefit (NCB)” (progression in <12 weeks, n = 9). Proteins that differed between the patient groups were subsequently quantified in AKT1- or PIK3CA-altered breast cancer cell lines with varying capivasertib sensitivity. The measured concentrations of AKT1 and AKT2 varied among the PIK3CA-mutated tumors but did not differ between the CB and NCB groups. However, analysis of the global proteome data showed that translational activity was higher in tumors of the NCB vs. CB group. When reproducibly quantified by validated LC-MRM-MS assays, the same proteins of interest similarly distinguished between capivasertib-sensitive versus -resistant cell lines. The results provide further evidence that increased mTORC1-driven translation functions as a mechanism of resistance to capivasertib monotherapy. Protein concentrations may offer additional insights for patient selection for capivasertib, even among genetically preselected patients.
Significance:
Capivasertib’s first-in-class FDA approval demonstrates its promise, yet there remains an opportunity to optimize its use. Our results provide new evidence that proteomics can stratify genetically preselected patients on clinical benefit. Characterization of the same profile in cell lines furnishes additional validation. Among PIK3CA-altered tumors, increased mTORC1-driven translation appears to confer intrinsic resistance. Assessing mTORC1 activation could therefore prove a useful complement to the existing genetic selection strategy for capivasertib.
Machine learning-based anomaly detection for smart home networks under adversarial attack
Authors: Rejito Juli , Stiawan Deris , Alshaflut Ahmed , Budiarto Rahmat
Published: August 2024

As smart home networks become more widespread and complex, they are capable of providing users with a wide range of applications and services. At the same time, the networks are also vulnerable to attack from malicious adversaries who can take advantage of the weaknesses in the network's devices and protocols. Detection of anomalies is an effective way to identify and mitigate these attacks; however, it requires a high degree of accuracy and reliability. This paper proposes an anomaly detection method based on machine learning (ML) that can provide a robust and reliable solution for the detection of anomalies in smart home networks under adversarial attack. The proposed method uses network traffic data of the UNSW-NB15 and IoT-23 datasets to extract relevant features and trains a supervised classifier to differentiate between normal and abnormal behaviors. To assess the performance and reliability of the proposed method, four types of adversarial attack methods: evasion, poisoning, exploration, and exploitation are implemented. The results of extensive experiments demonstrate that the proposed method is highly accurate and reliable in detecting anomalies, as well as being resilient to a variety of types of attacks with average accuracy of 97.5% and recall of 96%.
Improving support vector machine and backpropagation performance for diabetes mellitus classification
Authors: Prastyo Angga , Sutikno Sutikno , Khadijah Khadijah
Published: August 2024

Diabetes mellitus is a glucose disorder disease in the human body that contributes significantly to the high mortality rate. Various studies on early detection and classification have been conducted as a diabetes mellitus prevention effort by applying a machine learning model. The problems that may occur are weak model performance and misclassification caused by imbalanced data. The existence of dominating (majority) data causes poor model performance in identifying minority data. This paper proposed handling the problem of imbalanced data by performing the synthetic minority oversampling technique (SMOTE) and observing its effect on the classification performance of the support vector machine (SVM) and Backpropagation artificial neural network (ANN) methods. The experiment showed that the SVM method and imbalanced data achieved 94.31% accuracy, and the Backpropagation ANN achieved 91.56% accuracy. At the same time, the SVM method and balanced data produced an accuracy of 98.85%, while the Backpropagation ANN method and balanced data produced an accuracy of 94.90%. The results show that oversampling techniques can improve the performance of the classification model for each data class.
Development of learning videos for natural science subjects in junior high schools
Authors: Siswosuharjo Partono , Al-Bahra Al-Bahra , Sunaarya Po Abas
Published: August 2024

The purpose of this study was to determine the development procedure and the feasibility of learning media for whiteboard animation in Natural Sciences subjects at SMP Padindi, Tangerang Regency. This study uses a research and development (R&D) approach. The development model in this study is the analysis design development implementation evaluation (ADDIE) model. The feasibility test is carried out by means of individual testing (one to one) on 3 experts, namely material experts, learning experts, and media experts, as well as 3 students. In addition, a small group test was also carried out on 9 students. The results showed that: i) the material expert test was 87.5%, the learning expert was 85%, the media expert was 84.44%, 3 students were 88.84%, and the small group was 90%; and ii) this whiteboard animation learning media is suitable for use based on the results of media trials by experts and students.
Clustering man in the middle attack on chain and graph-based blockchain in internet of things network using k-means
Authors: Nuzulastri Sari , Stiawan Deris , Satria Hadipurnawan , Budiarto Rahmat
Published: August 2024

Network security on internet of things (IoT) devices in the IoT development process may open rooms for hackers and other problems if not properly protected, particularly in the addition of internet connectivity to computing device systems that are interrelated in transferring data automatically over the network. This study implements network detection on IoT network security resembles security systems from man in the middle (MITM) attacks on blockchains. Security systems that exist on blockchains are decentralized and have peer to peer characteristics which are categorized into several parts based on the type of architecture that suits their use cases such as blockchain chain based and graph based. This study uses the principal component analysis (PCA) to extract features from the transaction data processing on the blockchain process and produces 9 features before the k-means algorithm with the elbow technique was used for classifying the types of MITM attacks on IoT networks and comparing the types of blockchain chain-based and graph-based architectures in the form of visualizations as well. Experimental results show 97.16% of normal data and 2.84% of MITM attack data were observed.
Acoustic echo cancellation system based on Laguerre method and neural network
Authors: Nguyen Duy-Thao , Nguyen Thanh-Nghia
Published: August 2024

Acoustic echo cancellation (AEC) is a fundamental requirement of signal processing to increase the quality of teleconferences. In this paper, a system that combines the Laguerre method with neural networks is proposed for AEC. In particular, the signal is processed using the Laguerre method to effectively handle nonlinear transmission line system. The results after applying the Laguerre method are then fed into a neural network for training and acoustic echo cancellation. The proposed system is tested on both linear and nonlinear transmission lines. Simulation results show that combining the Laguerre method with neural networks is highly effective for AEC in both linear and nonlinear transmission lines system. The AEC results obtained by the proposed method achieves a significant improvement in nonlinear transmission lines and it is the basis for building a practical echo cancellation system.
Implementation of automation configuration of enterprise networks as software defined network
Authors: Prasetyo Lindo , Prihandi Ifan , Rifqi Muhammad , Budiarto Rahmat
Published: August 2024

Software defined network (SDN) is a new computer network configuration concept in which the data plane and control plane are separated. In Cisco system, the SDN concept is implemented in Cisco Application Centric Infrastructure (Cisco ACI), which by default can be configured through the main controller, namely the Application Policy Infrastructure Controller (APIC). Conventional configuration on Cisco ACI creates problems, i.e.: the large number of required configurations causes the increase of time required for configuration and the risk of misconfiguration due to repetitive works. This problem reduces the productivity of network engineers in managing Cisco system. In overcoming these problems, this research work proposes an automation tool for Cisco ACI configuration using Ansible and Python as an SDN implementation for optimizing enterprise network configuration. The SDN is implemented and experimented at PT. NTT Indonesia Technology network, as a case study. The experimental result shows the proposed SDN successfully performs multiple routers configurations accurately and automatically. Observations on manual configuration takes 50 minutes and automatic configuration takes 6 minutes, thus, the proposed SDN achieves 833.33% improvement.
Assessing community pharmacists' thoughts on telepharmacy in Bali province
Authors: Widowati I Gusti Ayu Rai , Suryaningsih Ni Putu Aryati , Sutema Ida Ayu Manik Partha , Adrianta Ketut Agus
Published: August 2024

Telepharmacy describes the use of technology in interactions between pharmacists and patients. Given that telepharmacy is the most recent development in the delivery of digital pharmacy services, the question of how prepared pharmacists are to provide high-quality services frequently comes up and receives attention. The purpose of this study was to determine the viewpoints of pharmacists in telepharmacy services. From February to April 2023, a cross-sectional survey was done using a Google form. The study population included 111 pharmacists in charge of network pharmacies in Bali Province. Their thoughts were assessed using a credible and reliable questionnaire created by the researchers. The questions were split into two sections: a professional demographic items, and a section describing the perspectives, benefits, and challenges of telepharmacy. To get a more detailed or comprehensive response, open-ended questions were added. In general, especially during a pandemic, pharmacists were aware of being involved in remote services (non-face-to-face interaction) and telepharmacy services. This study makes clear that pharmacists' involvement is essential for creating a long-distance relationship between them and their patients. Therefore, pharmacists should learn how crucial communication is to increase patient satisfaction.
Pre-clinical experiences among nursing students of reputable Islamic university in the capital city of Indonesia
Authors: Jamaludin Jamaludin , Rahmanda Mutiara Eka , Rahman Handono Fatkhur
Published: August 2024

Clinical trainings were employed in the nursing sciences in order to provide student’s experiences in applying nursing care according to the theory. They required to accomplish some competencies depending on their study levels. Students would also experience the possible barriers and challenge during clinical trainings. However, there were limited number of research which explored these experiences, especially in nursing students. This study aimed to explore the experiences of nursing students in performing fundamental nursing pre-clinical activities. This research conducted qualitative study with phenomenological approach. This study involved 5 nursing students according to inclusive criteria. Data collection method used in-depth interview techniques. The obtained data were analysed further using Colaizzi test. The collected data identified six themes of student’s experiences, such as student’s understanding about pre-clinic, their experiences during preclinic, theoretical gaps with hospital procedures, some barriers in clinical practice, student’s expectation, and obtained support during pre-clinic trainings. Pre-clinical trainings allowed nursing students to gain various medical experience and knowledge regarding nursing care. They could implement and compare the nursing theory with actual conditions in the hospital and society living. This topic needed to assess further about the benefits of pre-clinic trainings.
Spatio-temporal analysis of pulmonary tuberculosis in Astambul District, South Kalimantan, Indonesia 2020-2021
Authors: Rosadi Dian , Agustina Novita , Haji Darise Lasari Hadrianti , Fakhriadi Rudi , Fadillah Noor Ahda , Ali Indra Haryanto
Published: August 2024

Respiratory tuberculosis (TB) remains a significant global health concern and ranks among the top 10 leading causes of death worldwide, following human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Globally, it is estimated that 1.2 billion people are at risk of being infected with tuberculosis, and Indonesia is the country that contributes the third-highest number of TB cases worldwide, behind China and India. Tuberculosis is still a significant issue in South Kalimantan, notably in Banjar Regency. This study is a descriptive study that intends to identify respiratory TB clusters spatially and temporally in Astambul District during 2020–2021 with the SatScan application, which is visualized as a map of respiratory TB clusters using the Quantum GIS 3.28 application. Data on respiratory TB cases collected from the Banjar District Health Office were examined using retrospective space-time scan statistics, employing a Poisson probability model for analysis. This study found 4 respiratory TB clusters, and 2 of them had significant results, namely in 2020 (RR=6.90, p-value=0.000030) and 2021 (RR=5.27, p-value=0.00003). Factors that affect these clusters are population density, the physical condition of houses, humidity levels, and the availability of health facilities.
Patient safety culture as a mediator between healthcare personnel's psychological empowerment and patient outcome
Authors: Sutanto Eldaa Prisca Refianti , Antonio Ferdi , Massie Roy G.A.
Published: August 2024

Preventing healthcare errors and reducing damage are becoming the basic concepts of patient safety development. Healthcare personnel need to be more careful and minimize complications that can occur during patient care. Psychological empowerment is important to support a safety culture and patient outcomes. This study investigates the relationship between psychological empowerment (PE) and patient outcome (PO) mediated by patient safety culture (PSC). A cross-sectional survey study was conducted in private hospitals accredited by Joint Commission International. A total of 150 healthcare personnel as participants who met the requirements were obtained by distributing the questionnaires in March 2023. Significant results in mediating patient safety culture have been analyzed using partial least square-structural equation modeling (SEM). The dimensionality of PE and PSC was assessed by a new method that is a disjoint two-stage approach. The role of PSC was found to fully mediate the positive relationship between psychological empowerment and patient outcome (=0.436, p-value 0.05). This study contributes to growing the value of developing a safety culture and the function of psychological empowerment in healthcare staff to enhance patient outcomes.
Spatial analysis of environmental sanitation and stunting incidents
Authors: Tanjung Risnawati , Lestrina Dini , Sinaga Jernita
Published: August 2024

Environmental factors such as sanitation and hygiene, drinking water sources, quality of drinking water, and ownership of latrines are indirect factors causing stunting. This study aims to analyze the distribution of stunting and environmental sanitation factors that cause stunting in Dairi District, North Sumatra, Indonesia. The case-control design was carried out with 172 toddlers. The distribution pattern of stunting and the association of patient characteristics and environmental risk factors was carried out using the Geographic Information System. Data on healthy clean-living behavior was collected using a questionnaire, and microbiological laboratory tests measured water quality. The spatial analysis uses an average nearest-neighbor overlay. The association of characteristics and risk factors with the incidence of stunting was analyzed using chi-square and logistic regression. The average nearest neighbor analysis shows that the nearest neighbor index is 0.19 ( 0.05) are unrelated to stunting. The pattern of distribution of cases tended to be in clusters, and no relationship was found between population density and the incidence of stunting. The findings of this study provide a new understanding that health promotion to prevent stunting does not only focus on fulfilling nutrition but also on healthy clean-living behavior and water quality.
Factors of susceptibility to online romance scam in Malaysia: unraveling the complex pathways
Authors: Purwaningrum Evi Kurniasari , Ho Yi Ming , Imawati Diana , Prihadi Kususanto Ditto , Talib Mansor Abu
Published: August 2024

In this cross-sectional study, we delve into the multifaceted realm of online scam victimization by investigating a diverse array of individual factors that may predispose adults to fall prey to online scams. The central objective of this research is to ascertain the strongest predictor among the following variables: loneliness and the sense of mattering and to elucidate the moderating effect of social media engagement (SME) on the relationship between these predictors and online romantic scam (ORS) susceptibility (OSS). A sample of 380 adults aged 18 to 65 years (M=33.4) participated in this study to respond to demographic questionnaires and scales of the respective variable. The results suggested that the direct effect of relationship satisfaction on ORS susceptibility is not significant without the serial mediation roles of loneliness and mattering at a high level of SME. Further implications, limitations, and suggestions are discussed.
Cognitive behavior therapy intervention on adolescents to decrease anxiety problem study: the role of serotonin
Authors: Nancye Pandeirot Marjory , Husni Amin , Sawitri Dian Ratna
Published: August 2024

The existence of demands that occur simultaneously causes some adolescents to be unable to adapt properly, especially the condition of adolescents who experience changeable emotions, are unstable, easily stressed, feel anxious, depressed, and feel helpless. Cognitive behavior therapy (CBT) is a form of psychotherapy that can be used for adolescent emotional problems. The purpose of this study is to prove that CBT interventions can increase serotonin levels and reduce adolescent anxiety levels. The research population is adolescents with anxiety problems in the city of Surabaya. The research sample is 32 respondents with techniques systematic sampling. Inclusion criteria include: i) adolescents aged 12–18 years, ii) experiencing mental emotional anxiety problems as measured by a score with self-reporting questionnaire (SRQ-29), and iii) being willing to participate in the research and get permission from parents. Data collection using an instrument in the form of a Taylor Manifest Anxiety Scale (TMAS). The data have been analyzed by the Wilcoxon test. The results show that there were significant differences in serotonin levels and anxiety levels before and after the intervention given CBT. The average value of serotonin levels in the posttest was higher than the pretest (p=0.001) and the average value of anxiety levels in the posttest was lower than the pretest (p=0.043) indicating that giving CBT interventions was able to significantly reduce anxiety levels. CBT interventions are proven to increase serotonin levels and reduce adolescent anxiety levels. By changing the form of thought and the resulting consequences, the intensity of the subject's anxiety decreases.
Prevalence and determinants associated with adolescent idiopathic scoliosis: results of screening in Surakarta, Indonesia
Authors: Ramadhani Alinda Nur , Romadhoni Dea Linia , Awanis Almas
Published: August 2024

Scoliosis is defined as a vertebral deformity characterized by a lateral deviation of at least 10° with vertebral rotation. Adolescent idiopathic scoliosis is generally found in children aged 10-18 years. Changes in the scoliosis curve are influenced by various etiologic factors including age, sex, growth factors, curve location and biomechanical factors. The study was conducted to determine the prevalence of adolescent iidophatic scoliosis in school students aged 12-15 years in Surakarta city. Physical examination using Adam's forward bending test, scoliometer and risk factor questionnaire. The research subjects were 325 people with an age range of 12-15 years. Research subjects are included in the adolescent idiopathic scoliosis category if the Adam's forward bending test is positive and the scoliometer value is >10°. The highest prevalence of adolescent idiopathic scoliosis was found in school children aged 14 years. The prevalence of adolescent idiopathic scoliosis is higher in female (3.4%) than male students (0.3%). Determining factors that might influence the onset of adolescent idiopathic scoliosis including age, gender, biomechanical factors, habits or lifestyles factors and physical activity.
Peer support and healthy lifestyle among adolescents in urban areas in Indonesia
Authors: Rachmawati Praba Diyan , Krisnana Ilya , Kurnia Iqlima Dwi , Quraniati Nuzul , Arief Yuni Sufyanti , Danasari Titis Mustikowati , Rithpo Pratuma
Published: August 2024

Unhealthy lifestyles among adolescents in urban areas are still a problem. Peers are role models in adolescent's lifestyle. However, little is known about the peer support in eating behavior, sedentary lifestyle and physical activities, which thus needs to be explored. This study aims to analyze the relationship between peer support and adolescent lifestyle. This study used a cross-sectional design with a sample size of 105 adolescents using proportional stratified random sampling. Data were collected by questionnaire. The Spearman rho test was performed to identify the relationship between peer support within a sedentary lifestyle and eating behavior, while to identify the relationship between peer support and physical activity using pearson, the level of significance was determined as p≤0.05. The results showed that there was a relationship between peer support and eating behavior (p=0.012; r=0.243) as well as adolescents' physical activity (p=0.001; r=0.324). There is no relationship between peer support and a sedentary lifestyle both on weekdays (p=0.181; r=0.131) and on weekends (p=0.735; r=0.033). The results show that peers have an important role in improving healthy lifestyle patterns in adolescents, especially in eating behavior and physical activity, so peer involvement interventions to improve healthy lifestyles in adolescents are recommended.
Loneliness in overseas students: reviewed from father nurturance
Authors: Sanjaya Ersa Lanang , Dorkas Mopheta Audiola
Published: August 2024

The uneven condition of education in Indonesia has led to the phenomenon of overseas students. This phenomenon is an effort made by prospective students to obtain higher quality education or more according to their interests. Students who migrate certainly face bigger challenges, one of which is loneliness. Many studies reveal that the negative impact of feelings of loneliness experienced by a person, so it requires further study. The main objective of this study is to see how father nurturance influences loneliness among overseas students. This study used a quantitative approach with a total of 107 respondents. From this study, it was found that the role of the father has a significant influence on feelings of loneliness experienced by overseas students.
The intercultural caring-coping patterns of disaster-displaced families in temporary shelters
Authors: Gallego Randy Ian Ferenal , Balabagno Araceli Ocampo
Published: August 2024

This integrative research review sought to explore the concepts of caring and coping in the context of the disaster-displacement phenomenon. It intended to describe and characterize the process of human flourishing amidst crisis through the caring and coping experiences of people living temporarily in emergency shelters after having been forcefully displaced following a devastating disaster event. This review adopted the 11-step method introduced by Tawfik and his colleagues in 2019. Three databases were utilized which included CINAHL, PubMed, and ProQuest. Papers needed to be published in English, with full-text availability for their inclusion. A total of 16 references met the inclusion criteria for the final review. To construct a logical and coherent integration of the important points, four categories of themes were developed: i) disaster impacts on daily life patterns and cultural lifeways; ii) caring patterns during disaster displacement; iii) coping patterns during disaster displacement; and iv) cultural learnings for disaster-based practitioners. It was noted that despite the challenges of crises, disaster victims often recover naturally and return to their previous levels of functioning. Resilient caring-coping mechanisms enable people to flourish in adversity, with culture and traditions playing a vital role in shaping their adjustment and adaptation to current circumstances.
Analysis of vaccination policy in the era of the COVID-19 pandemic in Indonesia
Authors: Mustari Nuryanti , Junaedi Junaedi , Parawu Hafiz Elfiansya , Hawing Hardianto , Herman Herman , Syukri Ulfiah , Amri Aqmal Reza
Published: August 2024

This study aims to reflect on the pattern of vaccination policies implemented by the Indonesian government and to analyze public sentiment (pro/con) towards vaccination policies and the government's strategy in formulating democratic policies, prioritizing the aspirations of those affected by the policies adopted. This paper uses qualitative research methods with NVivo 12 Plus as a data processing tool. This study's results indicate that vaccination policies tend to be mandatory in Indonesia with an indirect compulsory application polarization. Hence, the government still uses a coercive and restrictive approach to vaccination programs. In Indonesia, vaccination policy intersects with ethical aspects, especially religious values, resulting in diverse public sentiments.
Family functions to increase breastfeeding self efficacy of adolescent primigravida
Authors: Hidayati Ratna , Huda Moch. Maftuchul , Setyorini Dhiana , Astutik Wahyu Sri
Published: August 2024

Primigravida in adolescence will experience changes in situations that require the ability to adapt to pregnancy, thereby affecting their confidence in breastfeeding their babies. The function of the family is to help prepare the pregnant mother's needs to face the changes of pregnancy, prepare for childbirth and overcome difficulties in breastfeeding. This research aims to determine the function of the family in increasing breastfeeding self-efficacy of adolescent primigravida. Correlational research design, population and sample of 124 teenage primigravida respondents using total sampling technique. The independent variable family function was measured using the family assessment device (FAD) questionnaire and the dependent variable breastfeeding self-efficacy using the breastfeeding self-efficacy scale short form (BSES-SF) questionnaire which was analyzed using the Rho Spearman rank test. The research results showed that almost all respondents (90.3%) had healthy family functions and almost all respondents (83.9%) had high self-confidence. The statistical test results showed a significant p-value of 0.000 (α<0.05) with r=0.746. The function of the family in providing a sense of security and comfort creates a positive attitude among adolescent primigravida towards breastfeeding self-efficacy. Breastfeeding self-efficacy needs to increase breastfeeding success and prevent stunting.
Social networking behaviour and psychological distress among Malaysian undergraduates during the COVID-19 pandemic
Authors: Teh Liang Jing , Wong Su Luan
Published: August 2024

This study investigated the extent of social networking sites usage and its relationship with the undergraduate students’ psychological distress during the COVID-19 pandemic. In this quantitative correlational study, 212 students completed questionnaires assessing their social networking site use and psychological distress. Descriptive analysis revealed that the students were avid users of social networking sites. On average, almost half of the students used social networking sites more than six times per day while more than onethird of them spent more than three hours each day using social networking sites. Findings also showed that entertainment was the primary purpose of social networking site usage, followed by academic, social, and informational uses. Notably, nearly half of the students reported high levels of anxiety, and approximately one-third experienced significant depression and stress. However, correlational analyses found no significant associations between the length, frequency, and all purposes (social, academic, information, or entertainment) of social networking site usage and the levels of depression, anxiety, and stress. These findings suggest a complex interplay between these variables. Given the ever-increasing use of social networking sites and the alarming prevalence of mental distress among students, further studies are needed to delve deeper into this multifaceted relationship.
Self-reported worry and action among Vietnamese citizens during the COVID-19 pandemic in 2021: latent class analysis
Authors: Pham Quoc Hung , Dao Anh Son , Pham Anh Tung
Published: August 2024

Describe the prevalence of and factors associated with self-reported worry and actions of Vietnamese citizens during the COVID-19 pandemic in 2021. A secondary data analysis was implemented using a cross-sectional survey conducted in 2021 among 447 adults living in Hanoi City from July to December 2021 and Ho Chi Minh City from May to October 2021. The hidden layers assessment results retained the 3-class model as the best-fitting one in the study. In this model, 28.4% of participants were in Class 2 - "Low Self-reported Worry and Moderate Action" group, 45.9% of the participants were classified into Class 1-"Moderate Self-reported Worry and Low Action" group, and 25.7% in Class 3 - "High Self-reported Worry and High Action" group. The multinomial logistics model showed that worrying about losing the house because of COVID-19 makes the expected participation risk of staying in latent class 1 lower for subjects high in latent class 3 (p<0.05). Our study identified the latent classes of self-protection action and awareness among Vietnamese citizens. The associated factor that impacted the classes was the fear of losing a house.
Sexual violence mitigation in realizing a violence-free campus
Authors: Nursyifa Aulia , Somantri Gumilar Rusliwa , Ery Seda Francisia Saveria Sika
Published: August 2024

Sexual violence occurs in higher education institutions. Sexual violence mitigation studies have a theoretical novelty using Giddens' structuring of the problem of sexual violence. The research aims to determine the relationship between policy stakeholders, lecturers, students, and education staff; know the obstacles and challenges; and know the model of sexual violence mitigation in higher education. The research used qualitative with case studies of three higher education in Indonesia. The informant consisted of 27 respondents: students, lecturers, and education staff. Data collection through interviews, documentation, observation, and focus group discussion (FGD). Data processing using the NVivo 12 Plus application; Publish or Perish; and VOSviewer. Data analysis using: data reduction; present data; and conclusion. This research shows that the relationship is very important between policymakers and lecturers, students, and education staff in efforts to prevent and handle sexual violence. Cooperation of all parties in facing challenges in handling and prevention of sexual violence on campuses that have obstacles, to realize a campus free from violence. This study concludes that realizing a campus that is free from sexual violence can be implemented on campuses in Indonesia. Recommendations for participatory and gender-responsive sexual violence mitigation policy models are applied in higher education in Indonesia.
Self-medication practices among customers at non-pharmacy outlets during COVID-19 pandemic in Indonesia
Authors: Wibowo Yosi Irawati , Kusuma Yana I Gusti Agung Ari , Puspa Sari Gusti Ayu Putu Laksmi , Sunderland Bruce , Setiadi Adji Prayitno
Published: August 2024

A cross-sectional study was performed to describe self-medication practices of customers at kiosks and minimarkets in District X, Indonesia, during COVID-19 pandemic in 2021. A sample of 98 customers from 67 kiosks, and 100 customers from 52 minimarkets were interviewed using a validated questionnaire. Descriptive statistics were used to summarise the findings. Most drugs purchased at kiosks and minimarkets were general sales drugs, i.e., analgesic-antipyretic (64.3% versus 46.0%); however, prescription drug sales were reported (3.1% vs 3.0%, respectively). Kiosk and minimarket customers purchased medications mainly based on the recommendations of non-health workers (69.4% vs. 34.0%, respectively), or electronic media (36.7% vs. 43.0%, respectively). The reasons to choose kiosks or minimarkets included accessibility, personal preferences, and service quality. Most kiosk/minimarket customers had knowledge on the drug brand names and indications, but only some knew the composition (8.16% vs. 29.0%, respectively) or side effects (9.18% vs. 35.0%, respectively). These findings indicated limited quality assurance on self-medication practices at non-pharmacy outlets.
Maternal hair lead and cytokine pro-inflammatory effects in preterm birth
Authors: Qolby Qonita Nur , Dewantiningrum Julian , Pramono Besari Adi , Maharani Nani , Nugraha Eka Djatnika , Muniroh Muflihatul
Published: August 2024

This case-control study analyzed the lead (Pb), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) levels in pregnant women with preterm birth (PTB) in Central Java, Indonesia. Hair samples from 72 pregnant women were collected non-invasively. The prenatal exposure to Pb was determined with the total reflection X-ray fluorescence (TXRF) method. Serum IL-6 and TNF-α were examined using enzyme-linked immunosorbent assays (ELISA). The Pb concentration in hair was slightly higher in women with PTB than those without PTB; however, this difference was not statistically significant. An elevated hair Pb level was not associated with increased PTB risk (OR 24.69, 95% CI 0.93–653.82, p>0.05). A serum TNF-α level ≥27 pg/ml, a serum IL-6 level ≥9 pg/ml, and the spouse’s smoking frequency were significantly associated with increased PTB risk (TNF-α OR 42.25, 95% CI 5.26–339.61; IL-6 OR 22.33, 95% CI 3.12–158.54; spouse’s smoking frequency OR 1.28, 95% CI 1.09–1.5), while the maternal hemoglobin concentration significantly decreased PTB risk (OR 0.43, 95% CI 0.2–0.927). This study demonstrates that maternal hair Pb concentration has no significant relationship with PTB. Serum TNF-α, IL-6, and the spouse’s smoking frequency potentially increased PTB risk, while the maternal hemoglobin level is a protective factor.
Global Leadership Initiative on Malnutrition criteria for predicting surgical site infection in elective laparotomy patients
Authors: Octaviani Pauline , Wulandari Yohannessa , Ibrahim Febiansyah , Andayani Diyah Eka
Published: August 2024

Laparotomy surgery patients are at risk for complication including surgical site infections (SSI) which are associated with high morbidity and mortality. Malnutrition has been identified as a risk factor for the occurrence of SSI but preoperative malnutrition identification remains low. The Global Leadership Initiative on Malnutrition (GLIM) has published a new, practical, and easily applicable definition of malnutrition. This study aims to evaluate whether malnutrition according to GLIM criteria is a predictor of SSI in elective laparotomy patients. This prospective cohort study involved 123 subjects aged 18-65 years undergoing elective laparotomy, without diabetes history. Their malnutrition status was assessed using GLIM criteria with bioelectrical impedance analysis (BIA) to evaluate muscle mass. A total 62 subjects were categorized into the malnutrition group and the remaining into nonmalnutrition group and then monitored for the presence of SSI up to 10 days postoperatively. SSI occurred in 13.8% of the subjects. The analysis showed a strong association between malnutrition and SSI in elective post laparotomy (RR 4.6; 95%CI 1.4-15.1; p=0.005). Malnutrition according to GLIM criteria is a significant predictor of SSI in elective post laparotomy patients.
Relationship between anxiety, loneliness, and sleep-disorders with social media addiction among adolescent
Authors: Sarfika Rika , 'Alini Zahratul , Refnandes Randy , Wijaya Nindi Eka , Saifudin I Made Moh. Yanuar
Published: August 2024

In the digital era, social media usage has become an integral part of daily life, particularly among adolescents. This study investigates the relationship between anxiety, loneliness, sleep disorders, and social media addiction among adolescents. A cross-sectional study involving 290 X and XI-grade students utilized standardized instruments: the Bergen Social Media Addiction Scale (BSMAS), Zung Self-Rating Anxiety Scale (SAS/SRAS), UCLA Loneliness Scale Version 3, and Pittsburgh Sleep Quality Index (PSQI). Bivariate analysis was conducted using the Chi-square test (p<0.05). Findings revealed 10.7% severe social media addiction, 21.4% severe anxiety, 4.8% significant loneliness, and 74.5% poor sleep quality. Significant associations were found between anxiety (p=0.013), loneliness (p=0.010), sleep disturbance (p=0.033), and social media addiction. Higher anxiety, loneliness, and poor sleep quality correlate with increased susceptibility to social media addiction among adolescents. This underscores the importance of addressing psychological well-being in interventions aimed at mitigating social media addiction.
Physical fitness and its impact on psychological health during the COVID-19 lockdown
Authors: Sharma Neharika , Singh Prabhdeep , Pore Prasad D
Published: August 2024

Both the countrywide lockdowns as well as the worldwide lockdown and social isolation norms had an immense psychological impact on the population as a consequence of the major change in lifestyle. The present study aimed to determine changes in physical activity during the second lockdown in the Indian population, and the impact of exercise on psychological health during the same time period. The study was conducted through circulation of online questionnaire and data was collected by snowball technique. The type of physical activity done by most people was under the low international physical activity questionnaire (IPAQ) category (56.36%) which increased during lockdown (63.57%). The IPAQ category of moderate activity showed a drop in numbers from 26.46% to 18.56% while high IPAQ scores were almost the same before and during lockdown. People with high and moderate IPAQ scores had a better psychological health status as compared to the Low category.
Knowledge and stigma of depression among adolescents in Indonesia: a cross-sectional study
Authors: Sarfika Rika , Permata Putri Indah , Mailani Fitri , Wijaya Nindy Eka , Saifudin I Made Moh. Yanuar , Efendi Ferry
Published: August 2024

Depression is a prevalent mental health issue among Indonesian adolescents. Adolescents grappling with depression face various challenges, including exclusion, discrimination, educational difficulties, and violations of human rights. Limited knowledge about depression contributes to stigma, which impacts teenagers' reluctance to seek professional help. This study aimed to examine the correlation between adolescents' knowledge and the stigma of depression. Using a cross-sectional framework, this study involved 240 high school students from grades 10, 11, and 12. All participants completed and returned the requisite instruments. Knowledge about depression was assessed using the adolescent depression knowledge questionnaire (ADKQ), while the depression stigma scale (DSS) was used to gauge levels of stigma. The relationship between knowledge and stigma was analysed using the Spearman rank test. The findings indicate that the mean score for adolescents' knowledge about depression was 7.00 (SD=2.72), while the mean score for stigmatisation of depression was 42.02 (SD=8.43). A significant relationship between knowledge and stigma was observed (p<0.0001), characterised by moderate strength and a negative direction (r=-0.45). The study concludes that more excellent knowledge about depression among adolescents is inversely related to the level of the stigma they harbour. It is therefore recommended that mental health nurses in Community Health Centers enhance educational and counselling programs to inform adolescents about depression better. Collaboration between academic institutions and healthcare facilities, along with the development of school-based mental health programs, is imperative for reducing the stigma associated with depression among students.