bluuebunny/crossref_metadata_2025 huggingface dataset:
Aydın Veteriner Hekimleri Odası’nın tarihi, yapısı ve işleyişi
Authors: KOÇ Aysun
Published: May 2020

Türk Veteriner Hekimleri Birliği 6343 sayılı kanun kapsamında 1954 yılında kurulmuştur. Türkiye’de aynı yıl içinde 16 veteriner hekimler odası kurulmuş ve faaliyetlerine başlamıştır. Veteriner hekim odaları, sınırları içerisinde en az 30 veteriner hekimin görev yaptığı illerde ya da birkaç ilin birleştirilmesiyle oluşturulan bölgelerde kurulmuşlardır. Oda kurulmadan önce Aydın’da hizmet veren veterinerler, İzmir Bölgesi Veteriner Hekimleri Odasına bağlı olarak çalışmalarını sürdürmüşlerdir. Takip eden yıllar içerisinde Aydın’da çalışan veteriner hekimlerin sayısının 30’u geçmesi üzerine, Adnan Menderes Üniversitesi Veteriner Fakültesi kurucu dekanı Prof. Dr. Necdet Güzel’in başkanlığında 1994 yılında Aydın Veteriner Hekimleri Odası kurulmuştur. Bu araştırmanın amacı, yirmi beş yıl önce 35 üye ile kurulup bugün 525 üye sayısına ulaşan Aydın Veteriner Hekimleri Odası’nın günümüze kadar olan tarihsel gelişimi ve faaliyetleri hakkında bilgi vermek ve ayrıca Ege Bölgesi ve tüm ülkede veteriner hekimlik mesleği ile ilgili katkılarını ortaya koymaktır.
Consciousness for animal welfare: A trial of multidisciplinary education.
Authors: ŞAFAK Etkin , SARAL Begüm , SALGIRLI DEMİRBAŞ Yasemin , ÖZTÜRK Hakan , EMRE Mehmet
Published: May 2020

Cats and dogs have been living with humans for centuries in various conditions and for various reasons. Various factors such as different housing conditions, owner’s expectations and attitudes may affect the well-being of domestic animals. It is the responsibility of Veterinarians to ensure that the environment meets their needs, which further determines the welfare levels of animals. In order to meet the needs of different pets, the products used for pets should be designed in line with these needs. It can be suggested that products that fully meet the needs of pets are possible only with a multidisciplinary education model including design and veterinary behavior. In this study, a multidisciplinary education model was used for the 3rd-grade industrial design students at the Department of Industrial Product Design, Middle East Technical University in the autumn 2018-2019 Semester to develop design solutions for improving the well-being of cats and dogs as well as their owners. 30 design students attended the program. They divided into 9 teams according to the species, and environment they chose. Two lecturers from the Faculty of Veterinary Medicine gave lectures about the emotional needs of dogs and cats to the design students and supervised them during the design process. As a result, significant improvements were detected in the awareness of the industrial design students of biological, emotional and behavioral needs of cats and dogs. Thirty different products with ideas targeting different problems such as dental health, drug application, grooming were designed by different teams. Most of the end products were scored between good (75-79) and outstanding (90-100) by the instructors from the Faculty of Veterinary Medicine. The results of this study show that multidisciplinary education and the exchange of information between different professions have a significant impact on product development success to improve the quality of life in animals.
A Note on the Stability of Some Functional Equations on Certain Groupoids
Authors: Senasukh Jedsada , Saejung Satit
Published: May 2020

In this paper, we show that the stability of Cauchy set-valued functional equations and of Jensen set-valued functional equations can be derived from the stability of the corresponding equations in single-valued version.
Study of the Stability of a Viscous Solution of Naftifin Hydrochloride with a Combination of Polyethylene Glycols for External Use
Authors: Kosenkova S. I. , Krasnyuk I. I. , Krasnyuk (jr.) I. I. , Belyatskaya A. V. , Stepanova O. I. , Mazyarkin E. V. , Korochkina T. V. , Kharitonov Yu. Ya.
Published: May 2020

Introduction. An innovative antifungal viscous solution based on naftifine hydrochloride with a combination of polyethylene glycols (PEG) was developed in the laboratory of Sechenov University. The developed preparation intended for external use. The active ingredient – naftifine hydrochloride has a wide spectrum of action against fungi cause onychomycosis. The polyethylene glycols are included in the developed dosage form of provide the necessary viscosity of the solution (for accurate application and retention in the field of application). The paper presents the results of a study of the stability of a viscous solution of naftifine hydrochloride with a combination of PEG for external use. Over the entire shelf life, the drug must retain the full its chemical, physical, biopharmaceutical and pharmacological properties.

Aim. Determination of stability and expiration date of the shelf life of the developed solution of naftifine hydrochloride for external use, intended for the treatment of mycosis of the nail.

Materials and methods. Naftifine hydrochloride solution, «Millipor» filter, UV spectrophotometry, potentiometry pH, capillary viscometry.

Results and discussion. In the course of the study, the shelf life of the developed alcohol solution of naftifin hydrochloride with a combination of PEG was experimentally determined. The stability of the dosage form was determined by accelerated aging at a temperature of 40 ± 2 °C, in vivo at a temperature of no higher than 25 °C; and in a refrigerator at a temperature of 8 ± 2 °C. Assessment of the stability of the alcohol solution of naftifine hydrochloride was carried out according to the following indicators: the volume of the contents of the bottle, appearance, pH, quantitative content of the active substance, viscosity.

Conclusion. Based on the studies, it is recommended to store the naftifine hydrochloride solution at room temperature not higher than 25 °C, in a dark place. It is also allowed to store the solution of naftifine hydrochloride in a refrigerator at a temperature of 8 ± 2 °C.
Development of the Composition and Technology of a Granular Dosage form Based on a Thick Milk Thistle Extract and Ademetionine
Authors: Pisarev D. I. , Novikov O. O. , Zhilyakova E. T. , Boyko N. N. , Abramovich R. A. , Potanina O. G. , Lazar S. , Sayed Ahmad A. , Nasser R.
Published: May 2020

Introduction. The creation of rational combined medicines with hepatoprotective activity is an urgent task of medicinal science. Ademetionin shows pharmacological ef-fectiveness in cytolysis, cholestasis, synthetic insufficiency. Silybin, in turn, is effective in cytolysis, synthetic insufficiency, mesenchymal inflammation, fibrosis and pathological regeneration. Thus, the combination of these substances covers almost the entire set of clinical and morphological syndromes of liver damage and has a wide range of effects in various liver pathologies.

Aim. The purpose of this study was to develop a combined granular dosage form containing a thick extract of milk thistle, ademetionin and analytical support for this process.

Materials and methods. To obtain a thick extract from the fruits of Silybum marianum L. a traditional percolation method was used in a battery of 3 diffusers. Extractant removal was performed using a rotary evaporator IR-1M3 under vacuum. For the analysis of silybin in the obtained thick extract from the fruit of S. marianum L. the method of HPLC was used. Validation evaluation of the method was performed according to generally accepted parameters.

Results and discussion. A modular combined dosage form based on a thick extract of S. marianum L. and ademethionine was developed. Lactose was introduced as an auxiliary agent. The quality of pellets was evaluated according to generally accepted criteria. The validation parameters of the manufactured dosage form were determined using the HPLC method. Accuracy and precision were determined by the method of additives in a series of 9 experimental samples of granules. The results of determining the linearity, precision and correctness of the method for determining silybin and ademetionin in a combined model drug form showed correct results.

Conclusion.Thus, a combined granular dosage form containing a thick extract of milk thistle, ademetionin, has been developed. Analytical support of this process using the HPLC method was performed. Validation studies of the developed methodology were carried out. The field of application of the obtained results is practical pharmacy. Further research should concern the conduct of a set of pharmacological tests.
The Study of Pharmacokinetics Parameters of Morphine Hydrochloride, Long-acting Tablets in Cancer Patients with Severe Chronic Pain Syndrome
Authors: Ezhova E. A. , Kotelnikova I. G. , Teteneva A. V. , Butuzova D. V. , Tetenev K. F.
Published: May 2020

Introduction. Effective drug therapy for cancer patients with chronic pain syndrome (CPS) of high intensity is one of the priorities of modern healthcare. Currently, non-narcotic and narcotic analgesics are used for pain relief according to a three-steps scheme. In the absence of contraindications, it is preferable to prescribe medications per os and prolonged forms, which will allow the patient to maintain selfcare and comfort.

Aim. To study the pharmacokinetic properties of a drug with a prolonged mechanism of action «Morphine hydrochloride», in a film-coated tablet formof a dosage 30 mg, in cancer patients with severe CPS.

Materials and methods. For the analysis of the pharmacokinetics of the studied drug after single and multiple doses of 20 patients who received 10- day analgesic therapy with the studied drug «Morphine hydrochloride», long-acting film-coated 30 mgtablets. manufacturer FSUE Moscow Endocrine Plant, Russia. Route of administration: per os. The study duration was 17 days: screening duration up to 7 days; duration of therapy up to 10 days.

Results and discussion. The concentration of morphine in plasma was determined by HPLC-tandem mass spectrometry, within 12 hours after taking the study drug (1 of long-acting, film-coated tablet 30 mg). The following pharmacokinetic parameters were obtained on Day 5: T1/2 – 6.08 ± 4.37 hours and 14.46 ± 30.86 hours, Tmax – 2.5 ± 1.86 hours, Cmax – 43.91 ± 27.24 ng/ml. Values of pharmacokinetic parameters averaged over all days are presented. It was found that T1/2 for the studied drug T1/2 is 9.21 ± 14.94 hours, Tmax 2.87 ± 2.36 hours. The average maximum concentration (Cmax) on the day of the study drug was 36.52 ng/ml.

Conclusion. As a result of the study of pharmacokinetics, it was found that the drug «Morphine hydrochloride», long-acting tablets film-coated with a of 30 mg was found in serum after oral administration after 15 minutes and reaches a maximum concentration in the blood in 3 hours, the half-life is on average 9 hours, the maximum concentration is 36.52 ng/ml.
Results of the Estimation of Biosimilarity of RinLiz® (LLC «GEROPHARM», Russia) and Humalog® (Lilly France, France) Using the Method of the Hyperinsulinemic Eulygemic Clamp on Healthy Voluntary
Authors: Mayorov A. Yu. , Fedotov I. A. , Drai R. V. , Avdeeva O. I. , Makarenko I. E.
Published: May 2020

Introduction. Insulin is the most effective hypoglycemic agent currently used in the clinical practice. Compared with recombinant human insulin, insulin lispro have a blood glucose profile that is much closer to physiological. The clinical trials program of insulin bioassays includes pharmacology studies: pharmacokinetics (PK), pharmacodynamics (PD), and a clinical safety study.

Aim. To compare PK and PD of RinLiz® U100, solution for intravenous and subcutaneous administration (LLC «GEROFARM», Russia) and Humalog® U100, solution for intravenous and subcutaneous administration (Lilly France, France) in hyperinsulinemic euglycemic clamp.

Materials and methods. This was randomized double-blind, two-arm crossover study in 28 healthy volunteers (NCT03604575). The studied preparations were injected before the clamp with a dose of 0.3 U/kg once subcutaneously in the area of subcutaneous fat in the anterior abdominal wall. During the study, regular blood sampling was performed; the amount of insulin lispro was determined by ELISA in the samples. The results of the determination were used to calculate the PK parameters and construct the curves «concentration – time». Based on the measurement of glycemia, the glucose infusion rate was adjusted. These data were used to calculate the PD parameters. The comparability of the studied drugs was considered proven if 90 % confidence intervals (CI) for the ratio of geometric mean PK parameters Cins. max and AUCins. 0-8 and 95 % CI for the ratio of geometric mean PD parameters GIRmax and AUCGIR0-8,5 were in the range of 80–125 %. Statistical data processing and presentation of the results was carried out using software packages R 3.4.2.

Results and discussion. In the course of CI comparative PK and PD of RinLiz® and Humalog®, it was revealed that they have comparable PK and PD profiles. The CI for the logarithmically converted ratios of the values of the PK parameters was Cins. max 85.99–96.85 % and AUCins. 0-8 90.58–97.28 %, the PD of the parameters were 95.64–118.94 for GIRmax and 96.5–121.36 for AUCGIR0-8.5, all the CIs correspond to the set the boundaries of 80–125 % to establish comparability between RinLiz® and the original drug.

Conclusion. The results demonstrated the high degree of similarity of RinLiz® U100 and Humalog® U100 in terms of PK, PD profiles and safety.
Development and Validation of Valganciclovir and its Active Metabolite Ganciclovir Determination in Human Plasma by HPLC-UV Method
Authors: Komarov T. N. , Shohin I. E. , Miskiv O. A. , Bogdanova D. S. , Aleshina A. V. , Medvedev Yu. V. , Bagaeva N. S.
Published: May 2020

Introduction. Viral infections are a serious problem that occurs during the use of immunosuppressants in preparation for organ transplantation and in the postoperative period. Cytomegalovirus (CMV) infection is one of the main causes of diseases in people with weakened immune systems. It has a direct impact on one’s body and makes it more likely to reject a transplanted organ. Antiviral drugs are used to treat and prevent this infectious disease. Valganciclovir is a prodrug whose active metabolite is ganciclovir. Valganciclovir is the drug of choice in the treatment of CMV infections. Currently, there are no researches on the matter of simultaneous determination of both valganciclovir and ganciclovir in human blood plasma by means of high-performance liquid chromatography (HPLC) with ultraviolet detection. This research delivers a thorough description of development and validation of a particular method for simultaneous determination of valganciclovir and ganciclovir in the plasma after sample preparation by the method of protein precipitation.

Aim. The aim of this study is to develop method for the quantitative determination of valganciclovir and its active metabolite ganciclovir in human plasma by HPLC-UV for pharmacokinetic studies.

Materials and methods. Quantitative determination of tadalafil in plasma by HPLC-UV. A sample was prepared using protein precipitation.

Results and discussion. This method was validated by next validation parameters: selectivity, matrix effect, calibration curve, accuracy, precision, lower limit of quantification, carry-over and stability.

Conclusion. The method of the quantitative determination of valganciclovir and its active metabolite ganciclovir in human plasma was developed and validated by HPLC-UV. The analytical range of the was 5,0–1000,0 ng/ml for valganciclovir and 100,0–10000,0 ng/ml for ganciclovir in plasma. Method could be applied to determination of valganciclovir and ganciclovir in plasma for PK and BE studies.
Immunogenicity Assessment of Pegfilgrastim in Patients with Breast Cancer
Authors: Medvedev Yu. V. , Kolganova M. A. , Sas O. A. , Komarov T. N. , Fisher E. N. , Shohin I. E. , Ammour Yu. I.
Published: May 2020

Introduction. Neutropenia, which is an abnormally low concentration of neutrophils in the blood, is one of the common side effects in patients receiving radio- or chemotherapy. Neutropenia usually leads to higher risks of severe bacterial and fungal infections. Such medicines as colonystimulating factor filgrastim (and its conjugates) are used to prevent and treat neutropenia in oncology patients. Immunogenicity is a potential concern for any biological product, thus, its assessment is one of the most critical necessities during the development and registration of such products.

Aim. The main aim of this study was to validate the ELISA method for anti-pegfilgrastim antibodies detection in human serum samples and to apply the validated method to pegfilgrastim drugs immunogenicity assessment.

Materials and methods. To assess pegfilgrastim immunogenicity, the commercial ELISA kit «PEGylated Filgrastim (Neulasta®) ADA ELISA» was used for screening, confirmatory and titer assay. Moreover, to confirm the chosen commercial kit suits the study aims it was revalidated. The absorbance values were obtained using plate immunoassay analyzer Stat Fax 3200, plate washing was performed using an automatic twochannel plate washer.

Results and discussion. The ELISA method for anti-pegfilgrastim antibodies determination in human serum samples was validated and applied to the analytical part of the comparative, multicenter, blind, randomized study of pegfilgrastim efficacy and safety in patients with breast cancer, receiving myelosuppressive chemotherapy. Human serum samples were first screened for anti-drug antibodies, then «screening positive» samples were analyzed in confirmatory assay with % inhibition calculation for each sample. The «confirmed positive» samples were further characterized in titer assay.

Conclusions. The ELISA method for anti-pegfilgrastim antibodies determination in human serum samples was successfully validated and applied for pegfilgrastim drugs immunogenicity assessment.
Polycomplex Carrier for Buccal Mucoadhesion Delivery of Metronidazole
Authors: Moustafine R. I. , Budnikov V. V. , Abdullina S. G. , Nasibullin Sh. F. , Saleev R. A.
Published: May 2020

Introduction. One of the well-known requirements for buccal drug delivery systems is the demonstration of mucoadhesive properties of the carrier, ensuring retention on the mucosa for a long time with the gradual release of the included drug. It should be noted that one of the advantages of buccal systems compared with oral ones is the absence of the «first pass effect» through the liver.

Aim. To carry out a physicochemical and pharmaceutical research of the interpolyelectrolyte complex (IPEC), obtained on the basis of pharmaceutically acceptable polymers – Eudragit® EPO and Noveon® AA-1, in comparison with the physical mixture and individual polymers, as a mucoadhesive delivery system of metronidazole for the treatment of periodontal diseases.

Materials and methods. Obtained on the basis of a pair of pharmaceutical polymers (Eudragit® EPO and Noveon® AA-1), two IPEC samples were characterized by elemental analysis, FTIR spectroscopy, and modulated temperature differential scanning calorimetry (mDSC) in comparison with individual polymers and their physical mixtures. The study of swelling ability, bioadhesion and release was carried out in a medium simulating artificial salivary fluid (pH 7.0) at a temperature of 37 ± 0.1 °C. Mucoadhesion of polymer samples and IPEC was studied using a TA.XTplus texture analyzer (Stable Micro Systems, UK). The release of metronidazole (MD) from matrices based on the developed IPEC was studied on a CE 7Smart USP 4 apparatus (Sotax, Switzerland) using the Flow Trough Cell method at a speed a flow of 20 ml/min in an open cycle within 5 hours. The amount of released MD was estimated by UV spectrophotometry on a Lambda 25 instrument (PerkinElmer, USA) at a wavelength of 319 nm.

Results and discussion. As a result of studies on the physicochemical and pharmaceutical properties, there was selected the optimal composition of a polycomplex carrier (IPEC 2) based on Eudragit® EPO and Noveon® AA-1, which is characterized by the required bioadhesive properties and the ability of providing controlled release of drug from the tablet matrix (with weight ratio MD/IPEC-2 1:0.5) in conditions mimicking oral cavity environment, which provides the necessary mode of buccal delivery of metronidazole in accordance with Fick's law of diffusion.

Conclusion. IPEC 2 is a perspective for use as carrier for buccal controlled delivery of metronidazole.
Quantitative Determination of Naltrexone Hydrochloride in a Nasal Spray by High-performance Liquid Chromatography
Authors: Domnina Yu. M. , Suslov V. V. , Kedik S. A. , Vorfolomeeva E. V. , Meleshko A. V.
Published: May 2020

Introduction. Naltrexone, an antagonist of µ-opioid receptors, is promising for the treatment of various autoimmune and oncological diseases when used in doses of 1.5–5 mg/day. To date, there are no medications that provide such dosages of naltrexone.

Aim. Development and validation of a method for the quantitative determination of naltrexone hydrochloride in a nasal spray by high performance liquid chromatography (HPLC).

Materials and methods. As an object of research, a naltrexone hydrochloride nasal spray was used. The quantitative determination of naltrexone in the test sample was developed using a Dionex UltiMate 3000 high-performance liquid chromatograph (Thermo Scientific, USA) equipped with a diode-matrix detector.

Results and discussion. The possibility of using isocratic and gradient chromatographic modes for the quantitative determination of naltrexone hydrochloride in the nasal spray was studied. Based on these results, a new method of determination using the gradient mode is proposed, which allows minimizing the influence of the polymer component in the test sample on the analysis results.

Conclusion. A new technique of high-performance liquid chromatography (HPLC) is proposed that allows identification and quantification of naltrexone hydrochloride in a nasal spray containing a high concentration of water-soluble heat-sensitive poloxamer as a thickener. The developed method was validated according to the parameters: correctness, precision, specificity, linearity.
Helmuth Plessner's Social and Political Thought in Light of his Philosophy of Life
Authors: Chrobak Karol
Published: May 2020

The essay contains an analysis of selected socio-political ideas of Helmuth Plessner. The basic assumption of this study is the existence of a close categorial relationship between Plessner’s reflections in The Limits of Community (1924) and in Die Stufen des Organischen (1928). As the interpretative key, the author uses one of the pivotal concepts of Plessner’s philosophy of life, namely the category of “border.” Showing the adequacy of this category in relation to Plessner’s social and political concepts, the essay addresses the issue of the individual-society relationship, the question of social roles and their possible deviations, and the problem of political leadership.
Inventarisasi Dan Kajian Etnobotani Tanaman Akuatik Di Taman Akuatik Kebun Raya Eka Karya Bali
Authors: A’tourrohman Muhammad
Published: May 2020

Eka Karya Botanic Garden is an ex situ conservation area located in Bali's Biosphere Reserve. As part of the biosphere reserve, the Eka Karya Botanical Garden plays an important role in conservation, research, tourism and education programs. The purpose of this study is to inventory the types of aquatic plants found in the Aquatic Park of the Eka Karya Bali Botanic Garden and to reveal ethnobotanical aspects of the aquatic plants. This study uses an exploration method, with Aquatic Park as a location for sampling and observation. The results of the study showed that 12 aquatic plants were found, namely Nasturtium officinale, Cyperus flabelliformis, C. papyrus, Acorus calamus, Pontederia cordata, Echinodorus paleafolius, Eichhornia crassipes, Nymphaea pubescens, Nymphoides indica, Zantedeschia aethiopica, Hydrilla verticillata, and Pistia stratiotes. Besides being used as food, phytoremediation, handicraft, and ornamental plants, aquatic plants are also useful as herbal medicines such as anti-inflammatory drugs, mouth ulcers, diaphoretics, diuretics, flu, stomach ache, fever, headaches, dysentery, antimicrobials, antioxidants, and so forth. The processing method is by grinding, boiling, chewing, drying, and eaten directly
Keanekaragaman Dan Kelimpahan Serangga Polinator Pada Perkebunan Mentimun (Cucumis sativus L) Desa Waiheru Ambon
Authors: Allifah AF Asyik Nur , Bahalwan Farida , Natsir Nur Alim
Published: May 2020

Pollinator insects are insects that play a role in pollination, namely intermediaries pollinating plants. The purpose of this study was to determine the abundance and diversity of insects pollinators in the Cucumber (Cucumis sativus L) Plantation of Waiheru Village, Baguala District, Ambon City. Sampling was done by purposive sampling using a yellow glue trap (Yellow sticky trap). The customer observations are made in visual control. Observation starts at 07.00 WIT until 18.00 WIT which is divided into 3 time periods, namely: 07.00-10.00 WIT, 11.00-14.00 WIT and 15.00-18.00 WIT. The data obtained were analyzed using the diversity index (H ') according to Shannon and Wiener. The results showed that the total abundance of pollinator insects in vegetable plantations was 1220 individuals, consisting of 3 orders and 5 families. Insect families that play a role in the process of pollination are Family Apidae, Formicidae, Syrpidae, Muscidae and Papilionidae. The highest abundance of insects is dominated by the Formicidae Family while the lowest abundance is the Papilionidae Family. Value insect pollinator diversity found among the sites that H '= 1.21 which indicates that the level of diversity of insect pollinators on plantations Cucumber (Cucumis sativus L) in the Waiheru Village, Baguala District, Ambon City in the medium category.
Mycological Characterization Of White Pustule Symptom On Ipomea Reptans Poir Leaves In Bogor-Indonesia
Authors: Putra Ivan Permana , Amelya Mega Putri
Published: May 2020

Ipomoea reptans Poir. (Convolvulaceae) is one of the favorite vegetables consumed by Indonesian citizens. However, the plant is commonly infected by white pustule symptom of particular pathogen on it’s leaves. The pustule known as white blister, is common disease in I. reptans Poir. leaves in Indonesia. Even so, till time, there was no microscopic description of this pathogen ever provided in previous reports in Indonesia. This study aimed to provide the biological information on the morphological and microscopic characteristics of the certain pathogen. The result revealed that the microorganism was Albugo ipomeae-aquaticae Sawada with brief characteristics in the following result.
Analisis Kemampuan Akumulasi Polyfosfat pada Tiap Fase Pertumbuhan Isolat Bakteri Toleran Uranium
Authors: Mutmainnah Heni , Rijal Muhammad
Published: May 2020

Polyphosphate is a straight chain biopolymer consisting of tens to hundreds of phosphate residues that are linked by high energy phosphoanhydride bonds, polyphosphate plays an important role in the bioremediation process of uranium waste, especially in the process of uranium metal precipitation in bacterial cells. Some bacteria are known to have the potential to interact with uranium through redox transformation and bioprecipitation by releasing inorganic phosphate to bind uranium in the environment. Inorganic phosphate results from degradation of polyphosphates that accumulate in cells. This study aims to determine the ability of uranium-tolerant bacteria to accumulate polyphosphates during their growth phase. Measurements were made in 5 growth phases, namely the lag phase, the logarithmic phase, the beginning of the stationary phase, the stationary phase, and the stationary end. Quantitative analysis of polyphosphate accumulations was carried out using the Olsen & Dean method. The test results are known that the uranium-tolerant bacterial isolat is able to accumulate the most optimal polyphosphate in the stationary phase, especially at the 48th hour and the lowest polyP accumulation is found in the initial stationary phase at the 24th hour.
DESKRIPSI KEPEMIMPINAN KEPALA DESA GAPURA KECAMATAN WATUKUMPUL KABUPATEN PEMALANG
Authors: Sulistiyo Heru
Published: June 2020

Leadership Description of the Head of the Gapura Village, Watukumpul District, Pemalang Regency. The practice of democracy has legitimized village leadership through village head elections. This legitimacy is a social asset that strengthens the village head to lead the village. Although in practice the implementation of government duties is certainly not enough if it only relates to public recognition, it requires administrative capabilities. At the concept and theory level, sometimes the village head cannot define in detail and measurably, but basically the nature of leadership values has been taken with simple patterns. Therefore, a combination of the two is needed so that the wheels of government can be implemented properly. The purpose of this study was to find out the leadership of the village head, to provide input to the District Head and Pemalang District Government about the leadership of the village head, and to provide an empirical picture to the readers as material for the study of governmental science development. This study uses a descriptive approach to describe existing phenomena, both natural and human engineering. The results show that at the empirical level the leadership values have been largely carried out by the Head of the Gapura Village, but the concepts of leadership in theoretical studies are still needed in addition to regulatory guidelines to complement the capacity of a village head
Early Effects of the COVID-19 Pandemic on Physical Activity and Sedentary Behavior in U.S. Children
Authors: Dunton Genevieve , Do Bridgette , Wang Shirlene
Published: May 2020

Background: COVID-19 restrictions such as closure of schools and parks, and the cancellation of youth sports and activity classes around the U.S may prevent children from achieving recommended levels of physical activity. Method: Parents of U.S. children (ages 5-13) completed an online survey between April 25-May 16, 2020 assessing their child’s physical activity (PA) and sedentary behavior (SB), perceived changes in PA and SB, and locations for PA. Results: Children (N = 211) were 53% female and 13% Hispanic. Parents of older vs. younger children perceived greater decreases in PA and greater increases in SB from the pre- (Feb 2020) to -early-COVID-19 (April-May 2020) periods. Children were more likely to perform PA at home or on neighborhood streets during the early- vs pre-COVID-19 periods. Conclusion: Short-term changes in PA and SB in reaction to COVID-19 may become permanently entrenched, leading to increased risk of obesity and diabetes in children.
ANALISIS TINGKAT KERUGIAN KEHILANGAN AIR PADA PROSES DISTRIBUSI SPAM UNS
Authors: Wulaningtyas Enggar Wahyu , Prakoso Ferry Dimas , Ariyani Meidi Putri , Pradipta Muhammad Iriandru , Yuniaristanto Yuniaristanto , Sutopo Wahyudi
Published: May 2020

As time goes by, there are more problems regarding the quantity and quality of water in Indonesia. One of these problems was found at Sebelas Maret University (UNS), precisely at Sistem Penyediaan Air Minum UNS (SPAM UNS). In serving its customers, SPAM UNS provides water tap and water dispenser facilities. However, there are still many weaknesses in the distribution of water. This is due to the frequent occurrence of pipe leaks and it takes a long time to find the location of the leak. As a result, financial losses experienced are quite large. The purpose of this study is to reduce losses by using the District Meter Area (DMA) concept to determine the area coverage (zoning) and the Analytical Hierarchy Process (AHP) method to determine the location of new reservoirs as a follow up of the zoning system. By implementing the DMA concept and the AHP method, SPAM UNS is able to reduce financial losses. The results obtained are making a new reservoir feasible because the value of the construction is almost the same as the initial loss value experienced by the UNS SPAM distribution network
ANALISIS PENINGKATAN PRODUKSI DENGAN RANCANG BANGUN ALAT PEMOTONG PADA PROSES PACKING
Authors: Sirait Ganda , Susanti Elva
Published: May 2020

Improving company productivity and efficiency in empowering human resource assessment is fulfilled to achieve company goals. one factor that can be done is the development of more effective equipment. Plastic cutting tools in the product packaging process are still simple, less efficient and less effective. The value engineering method is used as a method for selecting an alternative modification to a modified cutting tool and analyze it. At the analysis stage, two alternative modifications were modified from the improvement engine, where the initial design is used as a benchmark in performance evaluation. The result of tool design is the reduction in the number of defective products by 20.68% to 3.1% and The result of the cutting tool design is that there is an average increase in production 246 products per day.
Formulation of gel containing clotrimazole-loaded nanoparticles
Authors: Ho Hoang Nhan , Hoang Ngoc Tuan , Le Thi Minh Nguyet
Published: June 2020

Background: Clotrimazole (CLO) is an imidazole derivative with antifungal activities. The conventional dosage forms for oral or topical administration have some disadvantages such as drug adverse reaction for long-term use, repeated doses daily due to short half-life. The aim of this study was to prepare gel containing CLO-loaded nanoparticles to increase drug solubility, enhance bioavailability, especially for a sustained drug release.

Materials and methods: Eudragit RS 100 nanoparticles were prepared by the nanoprecipitation method, then was mixed with gel forming excipient. Gel containing CLO-loaded nanoparticles was characterized in terms of appearance, pH, particle size, PDI, encapsulation efficiency (EE), in vitro drug release.

Results: The best formulation of gel containing 1% of CLO-loaded nanoparticles with 0.3% of Carbopol 934P, 5% of glycerin was smooth, homogenous, and particle size, PDI, EE, drug release of 154.6 ± 3.6 nm, 0.153 ± 0.011, 67.62 ± 0.89%, 51.46 ± 1.10% (after 24 hours).

Conclusion: Gel containing CLO-loaded nanoparticles is a promising drug delivery system for the topical treatment of fungal infections.

Key words: clotrimazole, Eudragit RS 100, fungal infection, nanoparticle, topical treatment
Perancangan Ulang Tata Letak Fasilitas Produksi UKM Eko Bubut dengan Kolaborasi Pendekatan Konvensional 5 S dan Systematic Layout Planning (SLP)
Authors: Rahmawan Alfian , Adiyanto Okka
Published: May 2020

Pengaturan tata letak (layout) pabrik merupakan salah satu masalah yang sering dijumpai bahkan tidak dapat dihindari dalam dunia industi kecil maupun besar. UKM Eko Bubut merupakan UKM yang bergerak di bidang kerajinan kayu, UKM Eko Bubut ini memproduksi perlengkapan alat makan dari kayu berupa mangkok, piring, nampan, sendok, dan lain-lain Permasalahan yang dihadapi UKM Eko Bubut adalah pada tata letak lantai produksi yang tidak tertata rapi, dan tidak mempertimbangkan urutan proses pembuatan produk. Terdapat banyak departemen yang tidak tertata dengan baik, alat bantu / tools tidak ditata tetapi dibiarkan berserakan di area kerja. Bahan baku dan produk setengah jadi tidak tertata secara rapi dan banyak berserakan di area kerja. Kondisi ini mengakibatkan terganggunya aliran material masuk dan keluar pada setiap departemen sehingga jarak material handling menjadi lebih besar selain itu juga terdapat back tracking pada proses pembuatan mangkok kayu. Pendekatan yang dilakukan dalam mengatasi permasalahan pada UKM Eko Bubut yaitu dengan menerapkan pendekatan 5S dan metode Systematic Layout Planning (SLP). Pendekatan 5S digunakan untuk melakukan perencanaan layout supaya tertata rapi, ringkas, serta menciptakan kondisi kerja yang baik untuk pekerja. Metode Systematic Layout Planning (SLP) dipilih karena digunakan untuk merancang ulang layout lantai produksi dengan tujuan dapat meminimalkan material handling dengan mempertimbangkan aliran material. Setelah dilakukan pengolahan data menggunakan perancangan tata letak dengan dan metode Systematic Layout Planning (SLP), maka didapatkan 5 alternatif layout dengan jarak perpindahan material dan nilai OMH yang berbeda-beda. Layout alternatif yang dipilih berdasarkan nilai jarak perpindahan dan OMH terkecil yaitu layout alternatif 5 dengan total jarak perpindahan sebesar 71,4 meter dan OMH sebesar Rp. 31.338,-
Pemanfaatan Teknologi untuk Mendukung Kegiatan Belajar Secara Mandiri (Studi Kasus: Penggunaan Podcast oleh Mahasiswa di Kota Palangkaraya)
Authors: Norhayati Norhayati , Jayanti Sherly
Published: May 2020

Penelitian ini bertujuan untuk mengetahui sejauh mana pemanfaatan teknologi oleh para mahasiswa di kota Palangkaraya. Teknologi yang menjadi fokus disini adalah podcast. Podcast merupakan audio dan video yang marak digunakan sebagai sarana penyampaian informasi. Informasi yang diberikan sangat beragam, hal ini tergantung dari narasumber atau pembicara dalam topik podcast tersebut. Metode yang digunakan dalam penelitian ini adalah metode deskriptif studi. Data-data dikumpulkan dengan menggunakan lembar kuisioner semi terbuka and wawancara semi terstruktur. Analisa data yang dilakukan oleh peneliti adalah analisis persentase. Sehingga kemudian hasil analisis tersebut dijabarkan secara jelas guna menggambarkan keadaan objek secara konkrit dan riil. Hasil dari penelitian ini menyatakan bahwa 97% mahasiswa di kota Palangkaraya telah mengenal dan menggunakan podcast sebagai sarana untuk mendapatkan informasi terkait dengan bidang ilmunya masing-masing. Akan tetapi beberapa dari mereka masih mengalami kendala dalam memahami podast yang berbahasa Inggris.
Effect of Herringbone Technique on Studentsâ€™ Reading Comprehension through Narrative Text at MTs PAB 1 Helvetia, Medan
Authors: Losi Rizky Vita
Published: May 2020

The Effect of Herringbone Technique on Studentsâ€™

Reading Comprehension through Narrative Text

at MTs PAB 1 Helvetia, Medan

 

Rizky Vita Losi

Universitas Pembangunan Panca Budi

rizkyvitalosi@pancabudi.ac.id

 

Abstract

This research dealt with Herringbone technique which was proposed by Deegan (2006). The aim of this research was to know whether Herringbone technique was effective to be applied on studentsâ€™ reading comprehension through narrative text. The sample of this research was grade VIII-E students which consisted of 31 students at MTs PAB 1 Helvetia, Medan. The data of this research was studentsâ€™ reading comprehension score on pre-test and post-test. The data was analyzed by using Paired Sample T-Test formula which was calculated by SPSS 2.2. From the data analysis, it was found that the T-Test value was higher than the T-Table value (10,085 > 2,042). It showed that the alternative hypothesis (Ha) was accepted and the null hypothesis (Ho) was rejected. It also showed that there was a significance effect after applying Herringbone technique on studentsâ€™ reading comprehension through narrative text at MTs PAB 1 Helvetia, Medan.

 

Keywords:  herringbone technique, studentsâ€™ reading comprehension, paired sample t-test formula
MEKANISME CORPORATE GOVERNANCE TERHADAP KINERJA KEUANGAN PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BEI
Authors: Alfian Nurul
Published: May 2020

Implementationof good corporate governance can be considered as a way to improve the image of the bank declined, protect the interests of stakeholders and improve regulatory compliance to applicable law and ethics in the banking industry in improving the banking system is healthy. This research was conducted to examine the mechanism of corporate governance (managerial ownership, institutional ownership, and corporate audit committee) that affect the performance of financial statements. The research method use multiple linear regression analysis and the sampling technique use purposive sampling method. The results of this study present that there is a significant influence of managerial ownership, institutional ownership and corporate audit committee on financial performance.
Şarkılarla Değerler Eğitiminin Okul Öncesi Çocukların Farkındalık Düzeyine Etkisi
Authors: GÜL Gülnihal , MİNTAŞ Seda , ENGÜR Doruk
Published: May 2020

Bu çalışmada, okul öncesi dönemde şarkılarla değerler eğitiminin çocukların farkındalık düzeyine etkisinin belirlenmesi amaçlanmıştır. Bu amaç doğrultusunda 2018-2019 eğitim/öğretim yılında Bursa’da yer alan, kolay ulaşılabilir örnekleme yöntemiyle seçilmiş bir okul öncesi kurumdaki çocuklardan oluşan çalışma grubuyla ön test – son test statik gruplu deneysel bir çalışma yürütülmüştür. Çalışma kapsamında önce değerler ve bu değerlere ilişkin şarkı dağarcığı belirlenmiştir. Değerlerin belirlenmesinde 3 alan uzmanına Okul Öncesi Eğitim Programında yer verilen değerleri içeren bir liste verilmiş ve uzmanlardan bu değerlerin öğretiminde kullanılabilecek şarkı önerileri istenmiştir. En çok önerilen dört değer ve bu değerlerin öğretilmesine uygun şarkılar çalışma kapsamına alınmıştır. Belirlenen değerlerle ilgili çocukların farkındalık düzeylerini tespit etmek amacıyla “Resimli Kartlar Testi” geliştirilmiş ve bu test ile deney ve kontrol gruplarının ön test puanları belirlenmiştir. Daha sonra belirlenen dağarcık ile 8 hafta boyunca deney grubuyla çalışılmış ve uygulama sonrasında iki gruba tekrar aynı test uygulanarak son test puanları belirlenmiştir. Ön test ve son test arasındaki değişime ilişkin olarak Wilcoxon işaretli sıralama testi ve gruplar arasındaki farkların belirlenmesinde Mann-Whitney U testi kullanılmıştır. Analizler sonucunda grupların arkadaşlık, güven ve yardımseverlik alt boyutları ile toplam puanlarındaki gelişmeleri arasında deney grubu lehine anlamlı fark (p<.05) olduğu belirlenmiştir.
İlkokul Matematik Ders Kitaplarında Sosyal Değerler
Authors: ŞAHİN Ömer , TUĞRUL Kübra
Published: May 2020

Bu çalışmanın amacı; ilkokul matematik ders kitaplarında sınıf düzeyi, öğrenme alanı ve yayınevi türüne göre sosyal değerlere nasıl yer verildiğini incelemektir. Çalışmanın amacı doğrultusunda nitel araştırma yöntemlerinden biri olan açıklayıcı-tanımlayıcı durum çalışması kullanılmıştır. Veri toplamanın ilk kısmında; Milli Eğitim Bakanlığı’nın öğretmenlere elektronik doküman sağlayan, www.eba.gov.tr sitesinde yer verilen matematik ders kitapları incelenmiştir. Ders kitaplarında yer alan sosyal değerlerin analiz edilmesinde nitel veri analiz tekniklerinden betimsel analiz tekniği kullanılmıştır. Araştırmada kullanılacak sosyal değerlerin belirlenmesi için literatürde yer alan sosyal değerlere ait sınıflandırmalardan bir çatı oluşturulmuştur. Bu araştırmanın çatısı; sevgi, saygı, sorumluluk, yardımlaşma, hoşgörü, iyilikseverlik, evrenselcilik ve nezaket sosyal değerlerinden oluşmaktadır. Veri toplamanın ikinci kısmında sınıf öğretmenlerinin matematik eğitiminde sosyal değerlere ilişkin görüşlerini almak için yarı-yapılandırılmış görüşmeler gerçekleştirilmiştir. Öğretmenlerle gerçekleştirilen görüşmelerden elde edilen veriler ise içerik analiz tekniği ile analiz edilmiştir. Araştırmanın sonucunda en az sosyal değere birinci sınıf düzeyinde rastlanırken, diğer üç sınıf düzeyinde ise sosyal değerlerin benzer bir şekilde dağıldığı görülmüştür. Ders kitaplarında en fazla sevgi değerine, en az ise hoşgörü değerine yer verildiği sonucuna ulaşılmıştır. Ayrıca en fazla sosyal değere “Sayılar ve İşlemler” öğrenme alanında yer verildiği görülmüştür. Sınıf öğretmenleri ise sosyal değerlere matematik kitaplarında yeterince yer verilmediğini ifade etmişlerdir.
Okul Öncesi Öğretmenlerinin Sanat ve Estetik Değerleri Kazandırma Öz Yeterlik Algılarının İncelenmesi
Authors: AKYILDIZ Salih
Published: May 2020

Bu araştırmanın amacı, okul
öncesi öğretmenlerinin sanat ve estetik değerlerin kazandırılması ile ilgili öz
yeterlik algılarını belirlemek ve yeterlik algılarının bazı değişkenlere göre
değişip değişmediğini incelemektir. Araştırma tarama modeline dayalı olarak
yürütülmüştür. Araştırmanın evreni, Trabzon il ve ilçe merkezlerindeki
okullarda görev yapan 646 okul öncesi öğretmeninden oluşmaktadır. Araştırmanın örneklemi,
küme örnekleme yöntemiyle seçilen 267 okul öncesi öğretmeninden
oluşturulmuştur. Veriler, “Sanat ve Estetik Alan Yeterlik Ölçeği” kullanılarak
toplanmıştır. Verilerin analizinde aritmetik ortalama, frekans, yüzde, bağımsız
gruplar t testi, tek yönlü varyans analizi ve Bonferroni testleri kullanılmıştır. Elde edilen bulgulara göre;
okul öncesi öğretmenlerinin sanat ve estetik alanla ilgili öz yeterlik
algılarının ölçeğin bilgi sahibi olma ve estetik bakma boyutlarında “yeterli”,
sanat uygulamalarına yer verme boyutunda ise “biraz yeterli” düzeyinde olduğu
tespit edilmiştir. Okul öncesi öğretmenlerinin öz yeterlik algılarının çeşitli
değişkenlere göre anlamlı şekilde farklılaştığı görülmüştür. Araştırmada okul
öncesi öğretmenlerinin sanat ve estetik değerlerin çocuklara kazandırılmasında
öz yeterlik algılarının çok yüksek olmadığı, sanat uygulamaları boyutunda ise
nispeten daha düşük olduğu; sanata olan merak ve ilgilerinin öğretmenlerin
sanat ve estetik değerleri kazandırma öz yeterlik algılarını olumlu yönde
etkilediği sonucuna varılmıştır.
Etkili Vatandaşlık Eğitiminde Değerler Eğitimi: Sosyal Bilgiler Öğretmenlerinin Düşünceleri
Authors: KARASU AVCI Emine , FAİZ Melike , TURAN Saim
Published: May 2020

Etkili vatandaşlık; haklarını bilmek, kullanmak,
sorumluluklarının bilincinde olmak, bu sorumlulukları yerine getirmek ve diğer
insanların haklarına saygı duymaktır. Değerler de vatandaşlık anlayışının
oluşturulmasında toplumsal tutum ve beklentileri yansıtmaktadır. Değerleri
benimsemiş bireylere hem etkili vatandaşların yetiştirilmesi hem de toplumsal
devamlılık için ihtiyaç duyulmaktadır. Dolayısıyla değerlerin ve Sosyal
Bilgiler dersinin etkili vatandaş profilinin geliştirilmesinde önemli rolü
bulunmaktadır. Sosyal Bilgiler dersinin temel amacının vatandaşlık eğitimi
olduğu düşünüldüğünde etkili vatandaş profilinin geliştirilmesinde Sosyal
Bilgiler dersinin önemli bir ayağı olan değerler ve değerler eğitiminin önemi
anlaşılmaktadır. Bu araştırmanın amacı etkili vatandaşlık eğitiminde değerler
ve değerler eğitimine yönelik Sosyal Bilgiler öğretmenlerinin düşüncelerini
ortaya koymaktır. Araştırma olgubilim deseninde tasarlanmıştır. Araştırmanın
çalışma grubunu Türkiye’nin çeşitli illerinde görev yapan ve araştırmaya
katılmayı gönüllü olarak kabul eden Sosyal Bilgiler öğretmenleri
oluşturmaktadır. Araştırmada veriler elektronik posta yoluyla gönderilen
yapılandırılmış görüşme formuyla elde edilmiştir. Veriler araştırma soruları
çerçevesinde betimsel analiz yoluyla çözümlenmiştir. Sosyal Bilgiler
öğretmenlerinden elde edilen veriler vatandaşlık ve değerler arasındaki
ilişkiyi değerlerin vatandaşlığın şekillenmesine katkı sağladığı; etkili bir
vatandaşın vatanseverlik, sorumluluk, dürüstlük, çalışkanlık, bilimsellik,
saygı ve eşitlik gibi değerlere sahip olacağı; Sosyal Bilgiler dersinin yine
benzer değerlerle etkili vatandaşlık eğitimine katkı sağladığı ve Sosyal
Bilgiler Öğretim Programı’nda verilen değerlerin etkili vatandaşlık eğitimi
için yeterli olduğu yönündedir.