bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Solvent Composition for Absorption-Based Acid Gas Removal Unit on Gas Sweetening Process
Authors: Faqih Mochammad , Omar Madiah Binti , Wishnuwardana Rafi Jusar , Ismail Nurul Izni Binti , Mohd Zaid Muhammad Hasif Bin , Bingi Kishore
Published: September 2024

The gas sweetening process is essential for removing harmful acid gases, such as hydrogen sulfide (H2S) and carbon dioxide (CO2), from natural gas before delivery to end-users. Consequently, chemical absorption-based acid gas removal units (AGRUs) are widely implemented due to their high efficiency and reliability. The most common solvent used in AGRU is monodiethanolamine (MDEA), often mixed with piperazine (PZ) as an additive to accelerate acid gas capture. The absorption performance, however, is significantly influenced by the solvent mixture composition. Despite this, solvent composition is often determined through trial and error in experiments or simulations, with limited studies focusing on predictive methods for optimizing solvent mixtures. Therefore, this paper aims to develop a predictive technique for determining optimal solvent compositions under varying sour gas conditions. An ensemble algorithm, Extreme Gradient Boosting (XGBoost), is selected to develop two predictive models. The first model predicts H2S and CO2 concentrations, while the second model predicts the MDEA and PZ compositions. The results demonstrate that XGBoost outperforms other algorithms in both models. It achieves R2 values above 0.99 in most scenarios, and the lowest RMSE and MAE values of less than 1, indicating robust and consistent predictions. The predicted acid gas concentrations and solvent compositions were further analyzed to study the effects of solvent composition on acid gas absorption across different scenarios. The proposed models offer valuable insights for optimizing solvent compositions to enhance AGRU performance in industrial applications.
Exploring the Impact of Subtle Differences in the Chemical Structure of 1-Alkylsulfates and 1-Alkylsulfonates on Their Interactions with Human Serum Albumin
Authors: Grabowska Ola , Singh Ankur , Żamojć Krzysztof , Samsonov Sergey A. , Wyrzykowski Dariusz
Published: September 2024

The objective of this study was to examine the interactions between anionic surfactants, specifically 1-alkylsulfonates (KXS) and 1-alkylsulfates (SXS) ions, with human serum albumin (HSA). A combination of experimental techniques, including isothermal titration calorimetry (ITC), steady-state fluorescence spectroscopy (SF), and molecular dynamics-based approaches was employed to gain a comprehensive understanding of these processes. It has been demonstrated that the subtle variations in the charge distribution on the anionic surfactant headgroups have a significant impact on the number of binding sites, the stoichiometry of the resulting complexes, and the strength of the interactions between the surfactants and the protein. Additionally, we established that the affinity of the investigated ligands to specific regions on the protein surface is governed by both the charge of the surfactant headgroup and the length of the aliphatic hydrocarbon chain. In summary, the findings highlight the crucial role of charge distribution on surfactant functional groups in the binding mode and the thermodynamic stability of surfactant–protein complexes.
Development of a Method for the Determination of Rifaximin and Rifampicin Residues in Foods of Animal Origin
Authors: Fan Li-Ping , Tao Qi , Wang Xiao-Qiao , Xu Xiao-Hui , Yang Ya-Jun , Li Jian-Yong
Published: September 2024

Rifaximin and rifampicin are good broad-spectrum antimicrobials. The irrational use of antimicrobial drugs in veterinary clinics could threaten public health and food safety. It is necessary to develop a reliable detection method of the residue for enhancing the rational supervision of the use of such drugs, reducing and slowing down the generation of bacterial resistance, and promoting animal food safety and human health. So, this study developed an LC-MS/MS method for the detection of rifaximin and rifampicin residues in animal-origin foods. The residual rifaximin and rifampicin of homogenized test materials were extracted with acetonitrile-dichloromethane solution or acetonitrile in the presence of anhydrous sodium sulfate and vitamin C, purified by dispersible solid phase extraction, determined by LC-MS/MS, and quantified by the internal standard method. The specificity, sensitivity, matrix effect, accuracy, and precision of the method were investigated in the edible tissues of cattle, swine, or chicken. In addition, the stability of the standard stock solution and the standard working solution was also investigated. The method was suitable for the muscle, liver, kidney, fat, milk, and eggs of cattle, swine, or chicken, as well as fish and shrimp. The specificity of the method was good, and the detection of the analytes was not affected by different matrices. Both the LOD and LOQ of the two analytes were 5 μg/kg and 10 μg/kg, respectively. The results of matrix effects in each tissue were in the range of 80–120%; there were no significant matrix effects. The average accuracy of rifaximin and rifampicin in different foodstuffs of animal origin was between 80% and 120%, and the method precision was below 20% (RSD). The proposed method showed good performance for determination, which could be employed for the extraction, purification, and detection of residual rifaximin and rifampicin in edible animal tissues. The pretreatment procedure of tissue samples was simple and feasible. The method was highly specific, stable, reliable, and with high sensitivity, accuracy, and precision, which met the requirements of quantitative detection of veterinary drug residues.
Ag/Mo Doping for Enhanced Photocatalytic Activity of Titanium (IV) Dioxide during Fuel Desulphurization
Authors: Hamza Zahraa A. , Dawood Jamal J. , Jabbar Murtadha Abbas
Published: September 2024

Regarding photocatalytic oxidative desulphurization (PODS), titanium oxide (TiO2) is a promising contender as a catalyst due to its photocatalytic prowess and long-term performance in desulphurization applications. This work demonstrates the effectiveness of double-doping TiO2 in silver (Ag) and molybdenum (Mo) for use as a novel catalyst in the desulphurization of light-cut hydrocarbons. FESEM, EDS, and AFM were used to characterize the morphology, doping concentration, surface features, grain size, and grain surface area of the Ag/Mo powder. On the other hand, XRD, FTIR spectroscopy, UV-Vis, and PL were used for structure and functional group detection and light absorption analysis based on TiO2’s illumination properties. The microscopic images revealed nanoparticles with irregular shapes, and a 3D-AFM image was used to determine the catalyst’s physiognomies: 0.612 nm roughness and a surface area of 811.79 m2/g. The average sizes of the grains and particles were calculated to be 32.15 and 344.4 nm, respectively. The XRD analysis revealed an anatase structure for the doped TiO2, and the FTIR analysis exposed localized functional groups, while the absorption spectra of the catalyst, obtained via UV-Vis, revealed a broad spectrum, including visible and near-infrared regions up to 1053.34 nm. The PL analysis showed luminescence with a lower emission intensity, indicating that the charge carriers were not thoroughly combined. This study’s findings indicate a desulphurization efficiency of 97%. Additionally, the promise of a nano-homogeneous particle distribution bodes well for catalytic reactions. The catalyst retains its efficiency when it is dried and reused, demonstrating its sustainable use while maintaining the desulphurization efficacy. This study highlights the potential of the double doping approach in enhancing the catalytic properties of TiO2, opening up new possibilities for improving the performance of photo-oxidative processes.
Persulfated Ascorbic Acid Glycoside as a Safe and Stable Derivative of Ascorbic Acid for Skin Care Application
Authors: Jesus Ana , Correia-da-Silva Marta , Confraria Catarina , Silva Sílvia , Brites Gonçalo , Sebastião Ana I. , Carrascal Mylène , Pinto Madalena , Cidade Honorina , Costa Paulo , Cruz Maria T. , Sousa Emília , Almeida Isabel F.
Published: September 2024

The pursuit of cosmetic ingredients with proven efficacy and safety that meet consumer needs drives the advancement of new products. Ascorbic acid (AA) is utilized in cosmetic products, predominantly for its potent antioxidant properties. Nonetheless, its instability compromises its efficacy. In this work, ascorbyl 2-O-glucoside persulfate (AAGS) was synthesized, characterized, and evaluated regarding its safety profile and potential bioactivities and the results were compared to AA and its glycoside AAG. Pre-formulation studies were performed to assess the stability of the compounds and their compatibility with typical excipients commonly used in topical formulations. AAGS did not affect the metabolic activity of keratinocyte, macrophage, and monocyte cell lines, up to 500 µM. AAGS also exhibited a non-prooxidant and non-sensitizing profile and anti-allergic activity by impeding the allergen-induced maturation of THP-1 cells. When compared to AA and AAG, AAGS was shown to be more stable at pH values between 5 and 7, as well as superior thermostability and photostability. AAGS demonstrated higher stability in metal solutions of Fe(II) and Mg(II) than AA. AAGS demonstrated similar DPPH radical scavenging activity compared to AA. These results provide useful information for the development of new AA derivatives, highlighting AAGS as a novel cosmetic ingredient.
Exploring the Impact of VR Scaffolding on EFL Teaching and Learning: Anxiety Reduction, Perceptions, and Influencing Factors
Authors: Huang Hsiang Ling
Published: September 2024

This study examined the use of virtual reality (VR) scaffolding in English as a Foreign Language (EFL) instruction, focusing on its effects on speaking anxiety and learner perceptions and the need for tailored assessment methods. The study involved 34 Taiwanese university medical students and utilized quantitative and qualitative questionnaires. The quantitative results indicated a significant reduction in speaking anxiety and positive perceptions of VR-assisted learning. Qualitative findings revealed that students experienced dual anxieties related to language and technology during VR learning and nervousness during performance evaluations in a VR setting. This study highlights the importance of creating interactive scaffolding that considers individual learner differences and supports personalized learning experiences. It also underscores the necessity of adopting assessment strategies that align with VR environments’ unique, immersive nature in language instruction. Our findings contribute to the growing body of research on VR applications in language learning, offering valuable insights for educators and researchers aiming to leverage this innovative technology in the EFL context.
Tunable Plasmon Resonance in Silver Nanodisk-on-Mirror Structures and Scattering Enhancement by Annealing
Authors: Hatsuoka Ryohei , Yamasaki Kota , Wada Kenji , Matsuyama Tetsuya , Okamoto Koichi
Published: September 2024

In this study, we evaluated the surface plasmon characteristics of periodic silver nanodisk structures fabricated on a dielectric thin-film spacer layer on a Ag mirror substrate (NanoDisk on Mirror: NDoM) through finite difference time domain (FDTD) simulations and experiments involving actual sample fabrication. Through FDTD simulations, it was confirmed that the NDoM structure exhibits two sharp peaks in the visible range, and by adjusting the thickness of the spacer layer and the size of the nanodisk structure, sharp peaks can be obtained across the entire visible range. Additionally, we fabricated the NDoM structure using electron beam lithography (EBL) and experimentally confirmed that the obtained peaks matched the simulation results. Furthermore, we discovered that applying annealing at an appropriate temperature to the fabricated structure enables the adjustment of the resonance peak wavelength and enhances the scattering intensity by approximately five times. This enhancement is believed to result from changes in the shape and size of the nanodisk structure, as well as a reduction in grain boundaries in the metal crystal due to annealing. These results have the potential to contribute to technological advancements in various application fields, such as optical sensing and emission enhancement.
Systematic Study of Reaction Conditions for Size-Controlled Synthesis of Silica Nanoparticles
Authors: Vörös-Horváth Barbara , Salem Ala’ , Kovács Barna , Széchenyi Aleksandar , Pál Szilárd
Published: September 2024

This study presents a reproducible and scalable method for synthesizing silica nanoparticles (SNPs) with controlled sizes below 200 nm, achieved by systematically varying three key reaction parameters: ammonium hydroxide concentration, water concentration, and temperature. SNPs with high monodispersity and controlled dimensions were produced by optimizing these factors. The results indicated a direct correlation between ammonium hydroxide concentration and particle size, while higher temperatures resulted in smaller particles with increased polydispersity. Water concentration also influenced particle size, with a quadratic relationship observed. This method provides a robust approach for tailoring SNP sizes, with significant implications for biomedical applications, particularly in drug delivery and diagnostics. Using eco-friendly solvents such as ethanol further enhances the sustainability and cost-effectiveness of the process.
A Hybrid Perovskite-Based Electromagnetic Wave Absorber with Enhanced Conduction Loss and Interfacial Polarization through Carbon Sphere Embedding
Authors: Lian Xuehua , Yao Yao , Xiong Ziming , Duan Yantao , Wang Jianbao , Fu Shangchen , Dai Yinsuo , Zhou Wenke , Zhang Zhi
Published: September 2024

Electronic equipment brings great convenience to daily life but also causes a lot of electromagnetic radiation pollution. Therefore, there is an urgent demand for electromagnetic wave-absorbing materials with a low thickness, wide bandwidth, and strong absorption. This work obtained a high-performance electromagnetic wave absorption system by adding conductive carbon spheres (CSs) to the CH3NH3PbI3 (MAPbI3) absorber. In this system, MAPbI3, with strong dipole and relaxation polarization, acts dominant to the wave absorber. The carbon spheres provide a free electron transport channel between MAPbI3 lattices and constructs interfacial polarization loss in MAPbI3/CS. By regulating the content of CSs, we speculate that this increased effective absorption bandwidth and reflection loss intensity are attributed to the conductive channel of the carbon sphere and the interfacial polarization. As a result, when the mass ratio of the carbon sphere is 7.7%, the reflection loss intensity of MAPbI3/CS reaches −54 dB at 12 GHz, the corresponding effective absorption bandwidth is 4 GHz (10.24–14.24 GHz), and the absorber thickness is 2.96 mm. This work proves that enhancing conduction loss and interfacial polarization loss is an effective strategy for regulating the properties of dielectric loss-type absorbing materials. It also indicates that organic-inorganic hybrid perovskites have great potential in the field of electromagnetic wave absorption.
Neuroprotective Properties of Rutin Hydrate against Scopolamine-Induced Deficits in BDNF/TrkB/ERK/CREB/Bcl2 Pathways
Authors: Sreelatha Inturu , Choi Ga-Young , Lee In-Seo , Inturu Omkaram , Lee Hyun-Sook , Park Yea-Na , Lee Cheol-Won , Yang Inkyou , Maeng Sungho , Park Ji-Ho
Published: September 2024

Background/Objectives: Alzheimer’s disease (AD) is an age-related degenerative brain disorder characterized by a progressive decline in cognitive function and memory. This study aimed to evaluate whether rutin hydrate (RH) has neuroprotective effects in an AD-like learning and memory impairment rat model induced by scopolamine (SCO). Methods: The rats were administered with RH (100 mg/kg) and SCO (1.5 mg/kg) and underwent behavioral tests, including the Morris water maze test, Y-maze test, and passive avoidance test, to evaluate their learning and memory abilities. Additionally, long-term potentiation (LTP) was induced to observe changes in the field excitatory postsynaptic potential (fEPSP) activity. Results: RH treatment attenuated the SCO-induced shortening of step-through latency in the passive avoidance (PA) test, increased the percentage of alternation in the Y-maze, and increased the time spent in the target zone in the Morris water maze (MWM). Moreover, RH increased the total activity of fEPSP following theta burst stimulation and attenuated the SCO-induced blockade of fEPSP. RH also ameliorated the SCO-induced decrease in the expression levels of the BDNF, TrkB, ERK, CREB, and Bcl-2 proteins and the increase in the Bax protein level in the rat hippocampus. This demonstrates that RH has beneficial neuroprotective effects in the brain, improving learning, memory, and synaptic plasticity in rats. Conclusions: Our results highlight the molecular and cellular mechanisms through which RH exerts its neuroprotective effects in the prevention and treatment of learning and memory deficit disorders. RH could potentially be used as a therapeutic strategy for the restoration of learning and memory function and the prevention of the progression of AD.
Immunostimulatory Effects of Gamisoyosan on Macrophages via TLR4-Mediated Signaling Pathways
Authors: Jeong Yun Hee , Li Wei , Yang Hye Jin , Choi Jang-Gi , Oh You-Chang
Published: September 2024

Background: This study aimed to analyze the immunostimulatory activity of gamisoyosan (GSS) on the activation of macrophages in RAW 264.7 cells and its underlying mechanisms. Methods: The effects of GSS on the secretion of nitric oxide (NO), immunomodulatory mediators, cytokines and mRNAs, and related proteins were assessed using the Griess assay, Western blotting, quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and H2DCFDA, respectively. The level of phagocytosis was determined by the neutral red method while the immune function of GSS was determined using adhesion and wound-healing assays. Results: GSS-treated macrophages significantly increased the production of NO, immunomodulatory enzymes, cytokines, and intracellular reactive oxygen species without causing cytotoxicity. GSS effectively improved macrophage immune function by increasing their phagocytic level, adhesion function, and migration activity. Mechanistic studies via Western blotting revealed that GSS notably induced the activation of the Toll-like receptor (TLR) 4-mediated mitogen-activated protein kinase, nuclear factor-κB, and protein kinase B signaling pathways. Conclusions: Overall, our results indicated that GSS could activate macrophages through the secretion of immune-mediated transporters via TLR4-dependent signaling pathways. Thus, GSS has potential value as an immunity-enhancing agent.
A Cross-Sectional Study of Pre-Prepared Foods Knowledge, Attitudes, and Practices of College Students in Central China
Authors: Wumaierjiang Reyisaimu , Xu Yijia , Wang Lei , Guo Taotao , Chen Guoxun , Li Rui
Published: September 2024

Objectives: This study aimed to investigate knowledge, attitudes, and practices related to pre-prepared foods among college students in Central China. Methods: From the end of May 2024 to June 2024, we completed a cross-sectional study using an online questionnaire. A total of 1676 questionnaires were distributed online, and 1566 valid questionnaires were collected. Data were analyzed using Kruskal–Wallis tests or Wilcoxon rank-sum tests for univariate analysis. A multiple linear regression model was employed with knowledge, attitudes, and practices scores as dependent variables to identify factors associated with the scores on pre-prepared food knowledge, attitudes, and practices. Results: The survey results showed that 56.7% of the participants had high knowledge scores, 4% of the participants had high attitudes scores, and only 0.4% of the participants had high practices scores. Multiple linear regression analysis showed that ethnicity, the number of children in the family, academic qualifications, and monthly living expenses were associated with college students’ knowledge of pre-prepared foods (p < 0.05). Gender and the satisfaction with school catering services were associated with college students’ attitudes of pre-prepared foods (p < 0.05). Gender, knowledge and attitudes were associated with practices of pre-prepared foods (p < 0.05). Conclusions: College students have a relatively high level of knowledge of pre-prepared foods. However, they have more negative attitudes and practices towards pre-prepared foods, and the overall KAP levels are low.
Macular Pigment Optical Density as a Measurable Modifiable Clinical Biomarker
Authors: Masri Abdul , Armanazi Mohammed , Inouye Keiko , Geierhart Dennis L. , Davey Pinakin Gunvant , Vasudevan Balamurali
Published: September 2024

Background: Carotenoids are present throughout retina and body its dense deposition leads to an identifiable yellow spot in the macula. Macular pigment optical density (MPOD) measured in the macula is vital to macular well-being and high-resolution visual acuity. MPOD has also been associated with various health and disease states. We sought to review the literature on this topic and summarize MPODs role as a measurable modifiable clinical biomarker, particularly as a measure of the eye’s antioxidant capacity in the context of oxidative damage and retinal ischemia. Methods: A literature review collated the articles relevant to MPOD, carotenoid intake or supplementation, and their influence on various health and disease states. Results: Literature reveals that MPOD can serve as a reliable biomarker for assessing the retinal defense mechanisms against oxidative stress and the deleterious effects of excessive light exposure. Elevated MPOD levels offer robust protection against the onset and progression of age-related macular degeneration (AMD), a prevalent cause of vision impairment among the elderly population. MPOD’s implications in diverse ocular conditions, including diabetic retinopathy and glaucoma, have been explored, underscoring the real need for clinical measurement of MPOD. The integration of MPOD measurement into routine eye examinations presents an unparalleled opportunity for early disease detection, precise treatment planning, and longitudinal disease monitoring. Conclusions: Longitudinal investigations underscore the significance of MPOD in the context of age-related ocular diseases. These studies show promise and elucidate the dynamic nuances of MPOD’s status and importance as a measurable, modifiable clinical biomarker.
Changes in Food Waste among a Sample of U.S. Consumers after Beginning Anti-Obesity Medication
Authors: Mansouri Jamil , Roe Brian E.
Published: September 2024

Background/Objectives: Glucagon-like peptide-1 agonists (GLP1As) are increasingly prescribed to treat obesity. While studies document how these medications impact dietary habits, their relationship to consumer food waste is unexplored. Approximately one-third of all food is wasted, which creates substantial economic and environmental damage. The purpose of this study is to assess how consumers alter food waste after beginning GLP1As and to identify factors associated with this relationship. Methods: Retrospectively reported changes in the amount of food wasted since beginning a GLP1A are gathered from a sample of 505 U.S. consumers via a self-administered online survey. Regression analysis yields associations between changes in post-GLP1A-uptake food waste and the length and type of medication use, medication side effects, post-uptake changes in dietary habits, and respondent characteristics. Results: A total of 25% of respondents agree they waste more food since beginning the medication, while 61% disagree. Respondents are significantly less likely to agree with this statement if they have been on the medication a longer time and are significantly more likely to agree if they reported experiencing nausea since beginning the medication. Dietary changes consistent with more vegetable intake are also significantly associated with less waste. Conclusions: Uptake of a novel class of anti-obesity medications may significantly affect food waste patterns. With the potential for widespread adoption of such medications, and given the societal import of reducing food waste, understanding the interaction of these two consumer trends is critical for projecting their joint impact on the food system and for equipping new GLP1A users to limit food waste.
Association between Remnant Cholesterol and Metabolic Syndrome among Chinese Adults: Chinese Nutrition and Health Surveillance (2015–2017)
Authors: Li Fusheng , Yuan Hongtao , Cai Shuya , Piao Wei , Nan Jing , Yang Yuxiang , Zhao Liyun , Yu Dongmei
Published: September 2024

Background: Remnant cholesterol (RC) is highly associated with several chronic diseases. However, the relationship between RC and Metabolic syndrome (MetS) remains unclear. The study’s objective is to illustrate the relationship of RC to MetS. Methods: The data were collected from the Chinese Nutrition and Health Surveillance (2015–2017), which included personal, household and dietary information. A total of 65,618 residents aged 20 years or older from 31 provinces in mainland China were included in this study. RC was calculated by the equation RC = TC − (LDL-C + HDL-C). The criteria for MetS were based on the 2020 Chinese Type 2 Diabetes Prevention and Treatment Guidelines. Logistic regression models were used to analyse the relationship between RC and MetS and every MetS component. The receiver operating characteristic (ROC) curve was established to evaluate the accuracy of RC in identifying MetS, and the area under the curve (AUC) and the best threshold were calculated. Results: The weighted RC level of Chinese residents aged 20 years or older was 0.48 mmol/L. Participants with high RC levels were likely to be elderly, have a higher prevalence of MetS, higher total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), hba1c, and lower high-density lipoprotein cholesterol (HDL-C). Sex, body mass index (BMI), education status, household yearly income per capita, marital status, area of the country, residence location, smoking status, fruit intake and sleep time had statistical differences in the RC group (p < 0.05). The OR of MetS gradually increased with an increase in the RC quartile (p < 0.01), and higher quartiles of RC (Q4) suggested the highest MetS risk. The prevalence of each MetS component gradually increased with an increase in the RC quartile. The ROC curve found that to identify MetS, the AUC and best threshold of RC were 0.71 and 0.52 mmol/L, respectively. Conclusions: RC had a positive association with MetS and each MetS component. The accuracy in identifying MetS was higher in RC than in other indexes. The current study could provide new scientific evidence for the early prevention and control of MetS.
Plant-Derived as Alternatives to Animal-Derived Bioactive Peptides: A Review of the Preparation, Bioactivities, Structure–Activity Relationships, and Applications in Chronic Diseases
Authors: Sun Li , Liu Jinze , He Zhongmei , Du Rui
Published: September 2024

Background/Objectives: At present, a large number of bioactive peptides have been found from plant sources with potential applications for the prevention of chronic diseases. By promoting plant-derived bioactive peptides (PDBPs), we can reduce dependence on animals, reduce greenhouse gas emissions, and protect the ecological environment. Methods: In this review, we summarize recent advances in sustainably sourced PDBPs in terms of preparation methods, biological activity, structure–activity relationships, and their use in chronic diseases. Results: Firstly, the current preparation methods of PDBPs were summarized, and the advantages and disadvantages of enzymatic method and microbial fermentation method were introduced. Secondly, the biological activities of PDBPs that have been explored are summarized, including antioxidant, antibacterial, anticancer and antihypertensive activities. Finally, based on the biological activity, the structure–activity relationship of PDBPs and its application in chronic diseases were discussed. All these provide the foundation for the development of PDBPs. However, the study of PDBPs still has some limitations. Conclusions: Overall, PDBPs is a good candidate for the prevention and treatment of chronic diseases in humans. This work provides important information for exploring the source of PDBPs, optimizing its biological activity, and accurately designing functional foods or drugs.
The Influence of Adherence to a Mediterranean Diet on Decompensation in Patients with Chronic Heart Failure
Authors: Jiménez-Torres Jose , Jiménez-Juan Carlos , Villa-Martínez Ana , Gutiérrez-García Marta , Moreno-Gaviño Lourdes , Aparicio-Santos Reyes , Romero-Muñoz Ángela , Goncet-Cansino M. José , Barón-Franco Bosco , Bernabeu-Wittel Máximo
Published: September 2024

Background: Chronic heart failure (CHF) is a major health problem, representing the main cause of hospitalization in people over 65 years of age. Several studies have associated the Mediterranean diet with a cardioprotective function, improving prognoses in patients with high cardiovascular risk. Our main objective is to determine whether higher adherence to the Mediterranean diet is associated with a lower severity of CHF, based on the number of decompensations and disease complications. Methods: This study was a single-center retrospective cohort study conducted at the Virgen del Rocío Hospital (Seville). Adherence to a Mediterranean diet was determined by the Mediterranean Diet Adherence Screener (MEDAS) in patients with chronic heart failure in a state of clinical stability, the number of decompensations in the 12 months before inclusion, cardiac biomarkers (NT-proBNP and CA125), evaluation of dyspnea, and quality of life assessment according to NYHA and KCCQ scales and analytical profiles. Results: Seventy-two patients were included (35 with high adherence to the Mediterranean diet and 37 with low adherence). The mean age was 81.29 ± 0.86 years. A trend towards fewer decompensations (1.49 ± 0.14 vs. 1.92 ± 0.17, p = 0.054) and lower NT-proBNP values (2897.02 ± 617.16 vs. 5227.96 ± 1047.12; p = 0.088) was observed in patients with high adherence compared to those with low adherence to the Mediterranean diet. Conclusions: Our results suggest that patients with CHF and high adherence to the Mediterranean diet have a tendency towards an improved cardiac profile, indicated by fewer decompensations and lower NT-proBNP levels. Future clinical trials are needed to substantiate these hypotheses.
Relationship between Food Habits, Nutritional Status, and Hormone Therapy among Transgender Adults: A Systematic Review
Authors: Sousa Ivo P. , Amaral Teresa F.
Published: September 2024

Background/Objectives: The current gender-specific nutritional assessment methods for the transgender population may not cover the unique physiological characteristics of the gender transition process. Considering the potential effects of hormone therapy (HT), it has become relevant to review current evidence on the nutritional status of the transgender population. This systematic review aims to provide an updated report of the characteristics of the nutritional status, including food habits, and eating disorders in transgender individuals undergoing HT. Methods: Five databases were researched (PubMed, Web of Science, Scopus, Scielo, and Cochrane Library) from database inception to May 2024. The PRISMA 2020 statement was used. Studies focusing on adult transgender individuals (18 to 65 years old) that included outcomes related to nutritional status, HT, and food habits were considered for this review. The NOS and NIH tools were chosen to perform the risk of bias and quality assessment. Results: A total of 122 studies were identified, and 27 were included in this review. These studies comprised sixteen cohorts, seven cross-sectional, and four case studies, with a combined number of 8827 participants. BMI was the most referenced parameter, varying between low weight and overweight. High food insecurity frequency, restricted eating behaviors, high fat intake, and low levels of vegetable, grain, and fruit consumption were also observed. Conclusions: While nutritional status was perceived as a relevant factor when administering HT, the relationship between HT with both nutritional status and food habits has been insufficiently explored and warrants further research.
Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression
Authors: Messing Melina , Torres Jacob A. , Holznecht Nickolas , Weimbs Thomas
Published: September 2024

Understanding chronic kidney disease (CKD) through the lens of evolutionary biology highlights the mismatch between our Paleolithic-optimized genes and modern diets, which led to the dramatically increased prevalence of CKD in modern societies. In particular, the Standard American Diet (SAD), high in carbohydrates and ultra-processed foods, causes conditions like type 2 diabetes (T2D), chronic inflammation, and hypertension, leading to CKD. Autosomal dominant polycystic kidney disease (ADPKD), a genetic form of CKD, is characterized by progressive renal cystogenesis that leads to renal failure. This review challenges the fatalistic view of ADPKD as solely a genetic disease. We argue that, just like non-genetic CKD, modern dietary practices, lifestyle, and environmental exposures initiate and accelerate ADPKD progression. Evidence shows that carbohydrate overconsumption, hyperglycemia, and insulin resistance significantly impact renal health. Additionally, factors like dehydration, electrolyte imbalances, nephrotoxin exposure, gastrointestinal dysbiosis, and renal microcrystal formation exacerbate ADPKD. Conversely, carbohydrate restriction, ketogenic metabolic therapy (KMT), and antagonizing the lithogenic risk show promise in slowing ADPKD progression. Addressing disease triggers through dietary modifications and lifestyle changes offers a conservative, non-pharmacological strategy for disease modification in ADPKD. This comprehensive review underscores the urgency of integrating diet and lifestyle factors into the clinical management of ADPKD to mitigate disease progression, improve patient outcomes, and offer therapeutic choices that can be implemented worldwide at low or no cost to healthcare payers and patients.
Examining Differences in Health-Related Technology Use between Millennial and Older Generations of Caregivers
Authors: Gallagher Virginia T. , Reilly Shannon E. , Martin David , Manning Carol , Shaffer Kelly M.
Published: September 2024

Background/Objective: Caregivers from the Millennial generation are an emerging and understudied group of unpaid care providers in America who may benefit from digitally delivered support. To inform the design/tailoring of interventions for this group, we aimed to understand how Millennials may differ from other generations of caregivers regarding digital health-related technology use. Methods: Using the Health Information National Trends Survey (HINTS), Version 6, we conducted a cross-sectional study comparing health technology access and use across four generations of unpaid caregivers (n = 545; Millennials, Gen X, Baby Boomers, and Silent Generation) of adults with chronic conditions using chi-square and Kruskal–Wallis non-parametric tests. Results: Compared to Baby Boomer and Silent Generation caregivers, Millennial caregivers more frequently reported having a cellular internet connection, using a wearable activity device, a health/wellness mobile application, choosing telehealth appointments for convenience, and most frequently used social media in general and to view health-related videos (ps < 0.005). Additionally, Millennials were more likely to report possessing a smartphone (compared to Gen X and Silent Generation) and more frequently used social media for peer interaction about health (compared to all older generations; ps < 0.005). Conclusion: Millennials differ from older generations of caregivers regarding health-related technology access and use, which may have implications for intervention design and tailoring.
Present but Absent—Nurses’ Experiences of How a Hospital Design with Only Single Bedrooms and the Technological Shift Affect Nursing
Authors: Roos Anne Karine Østbye , Grøndahl Vigdis Abrahamsen , Helgesen Ann Karin
Published: September 2024

Background: Hospitals are complex environments that bring together diverse aspects of technology, society, medicine, and architecture. The aim of this qualitative study was to examine how a hospital design with originally only single bedrooms and technological innovations affect nursing. Methods: Twelve interviews were conducted with registered nurses working in a hospital in Norway. Data were analyzed using conventional content analysis. Results: Results show that a layout with single bedrooms allows nurses to be present and improve patient care, but also complicates patient monitoring, leading to adverse events and patient isolation. Nurses may struggle to find colleagues, experiencing loneliness at work. Additionally, the use of technology, long corridors, and poorly positioned clinical support spaces can contribute to nurses’ mental and physical absence. Conclusions: This study provides knowledge that nurses working in a hospital environment designed with single bedrooms must modify their workflow and communication strategies. Technological advancements are necessary to support nurses’ presence and patient safety, and systems and clinical support spaces must be adequately adapted. Technologically advanced hospitals with only single bedrooms can make nurses feel both present and absent in patient care. This understanding holds significance in practical terms, offering insights to guide future hospital design and nursing practices.
Advancing Management of Oral Lesion Patients with Epidermolysis Bullosa: In Vivo Evaluation with Optical Coherence Tomography of Ultrastructural Changes after Application of Cord Blood Platelet Gel and Laser Photobiomodulation
Authors: Gambino Alessio , Sindici Ezio , Astesano Simona , Basiglio Lucia , Vallone Valeria , Arduino Paolo Giacomo
Published: September 2024

Background: Inherited epidermolysis bullosa (EB) is a group of genetic disorders with skin fragility and blistering. The use of Cord Blood Platelet Gel (CBPG) in combination with laser photobiomodulation (PBM) leads to a reduction in lesions. The aim of this study is to evaluate clinical and morphometric changes with Optical Coherence Tomography (OCT) during GPC-PBM therapy. Methods: OCT scanning before the first session (T0), with relative measurement of the thicknesses of the epithelium (EP) and lamina propria (LP), and three consecutive sessions (once daily for 3 days) of CBPG and PBM applications were performed. A new OCT scan at the end of the three sessions (T1) and a week after (T2) were performed. All OCT scans were compared with the values of healthy reference tissues of the same site. Results: A statistically confirmed increase in EP thickness and a decrease in LP thickness with a progressive reduction in inflammatory content were highlighted. This case series did not have recurrences in the treated sites, or adverse reactions to therapy. Conclusions: This study shows the advantages of OCT monitoring in evaluating the effects of therapy at an ultrastructural level with a possibility of obtaining objective, precise, and repeatable measurements with an atraumatic device.
Campylobacter coli Prosthetic Joint Infection: Case Report and a Review of the Literature
Authors: Jonckheere Stijn , Mairesse Celestin , Vandecandelaere Patricia , Vanbiervliet Jens , Terryn Wim , Somers Jan , Prevost Benoit , Martiny Delphine
Published: September 2024

Prosthetic joint infections caused by Campylobacter are uncommon, with the majority of cases being attributed to C. fetus. This case report represents the third instance of a prosthetic hip infection caused by C. coli following an episode of gastroenteritis and, notably, in an immunocompetent patient. The infection was successfully managed by surgical debridement and lavage with retention of the prosthesis and 12 weeks of antibiotics. Furthermore, we present the first whole-genome sequence of a Campylobacter strain responsible for prosthetic joint infection and offer a comprehensive review of the literature on such infections.
Dietary Nutrient Evaluations in a Cohort of Dogs with Aminoaciduric Canine Hypoaminoacidemic Hepatopathy Syndrome Inform Dietary Targets for Protein, Fat, Sodium, and Calcium
Authors: Rowe John C. , Luo Emmy , Cline Martha G. , Astor Michael , Loftus John P.
Published: September 2024

Aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) is a rare syndrome affecting dogs. Nutritional management is a pillar of optimal treatment. Currently, there are no specific published data to inform dietary nutrient composition selections for treating affected dogs. Thus, our goal was to establish nutrient targets for the dietary management of ACHES by comparing nutrient profiles of commercial and home-cooked diets fed to dogs after diagnosis and determine if different nutrient inclusions were associated with survival. This retrospective cohort study evaluated nutrient profiles of commercial diets (n = 10) and home-cooked diets (n = 8) fed to dogs with ACHES. Associations between dietary nutrient inclusions and survival duration were determined using Cox proportional hazard analysis. Home-cooked diets were significantly (p < 0.001) higher in dietary protein and several amino acids than commercial diets. Risks of death were significantly (p < 0.05) lower with increasing dietary protein (hazard ratio 0.92 [CI 0.82–1.0]) and sodium (hazard ratio 0.02 [CI < 0.01–0.38]) and higher for dietary fat (hazard ratios 1.15 [CI 1.02–1.37]). An increased risk of death with increasing dietary calcium did not achieve significance (p = 0.067, hazard ratio 9.92 [CI 1.02–201.0]). These results were used to recommend target dietary nutrient ranges, in g/1000 kcal, of 90–130 for protein, 20–40 for fat, 0.7–1.8 for sodium, and 1.0–2.8 for calcium for dietary ACHES management.
Mechanistic Exploration of Smilax glabra Roxb. in Osteoarthritis: Insights from Network Pharmacology, Molecular Docking, and In Vitro Validation
Authors: Ilyas Sidra , Baek Chae Yun , Manan Abdul , Choi Yeojin , Jo Hee-Geun , Lee Donghun
Published: September 2024

Background: Arthritis, a debilitating joint disease, remains a significant global health burden. This study uncovers the therapeutic potential of the medicinal plant Smilax glabra Roxb. (SGR) in attenuating progression of disease by modulating immune responses. Methods: Through computational approaches, key bioactive compounds in SGR were identified by using freely available databases: TCMSP, TCMID, HIT2.0, HERB, and INPUT in order to elucidate their underlying mechanisms of action. Therapeutic targets for the disease have been retrieved by TTD, GeneCard, and OMIM databases. The STRING database was used to analyze the protein–protein interactions (PPI) of intersecting genes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to reveal the functional roles of genes. Mcule was used for molecular docking and binding affinity of compounds and targets were evaluated by DeepPurpose model. ALP activity, cell viability assay, TRAP staining were also performed. Results: A total of 14 active SGR compounds with 59 common targets for arthritis have been identified. These targets have a major role in controlling biological processes such as wound healing, oxygen responses, and chemical stimuli. Molecular docking by Mcule platform demonstrated that quercetin and β-sitosterol showed higher binding energy affinities with TNF, TP53, PTGS2, and JUN as compared to other targets. To explore the complex relationship between compounds and targets, pre-trained Davis and KIBA models were used to predict the affinity values of selected compounds. In MC3T3-E1 cells, ALP activity was significantly increased and bone marrow macrophages (BMM) showed a low number of TRAP-positive cells in SGR-treated cells. Conclusions: Our findings demonstrate that SGR effectively inhibits/regulates inflammatory responses, prevents cartilage degradation, promotes bone regeneration, and can be used as a promising candidate for the development of novel arthritis treatment.
Multidrug Combinations against SARS-CoV-2 Using GS-441524 or Ivermectin with Molnupiravir and/or Nirmatrelvir in Reconstituted Human Nasal Airway Epithelia
Authors: Siegrist Denise , Jonsdottir Hulda R. , Bouveret Mendy , Boda Bernadett , Constant Samuel , Engler Olivier B.
Published: September 2024

Background. The emergence, global spread, and persistence of SARS-CoV-2 resulted in an unprecedented need for effective antiviral drugs. Throughout the pandemic, various drug development and treatment strategies were adopted, including repurposing of antivirals designed for other viruses along with a multitude of other drugs with varying mechanisms of action (MoAs). Furthermore, multidrug treatment against COVID-19 is an ongoing topic and merits further investigation. Method/Objectives. We assessed the efficacy of multidrug treatment against SARS-CoV-2 in reconstituted human nasal epithelia, using combinations of molnupiravir and nirmatrelvir as a baseline, adding suboptimal concentrations of either GS-441524 or ivermectin, attempting to increase overall antiviral activity while lowering the overall therapeutic dose. Results. Nirmatrelvir combined with molnupiravir, GS-441524, or ivermectin at suboptimal concentrations show increased antiviral activity compared to single treatment. No triple combinations showed improved inhibition of SARS-CoV-2 replication beyond what was observed for double treatments. Conclusions. In general, we observed that the addition of a third compound is not beneficial for antiviral activity, while various double combinations exhibit increased antiviral activity over single treatment.
The Multiple Aspects of the Given—Ontological Remarks on Ernst Mach’s Empiricism
Authors: Lindén Jan-Ivar
Published: September 2024

Philosophers often rely on sciences of their own time. This is especially true for scientists writing philosophical works. In the case of Ernst Mach, the scientific references are mainly to physics, physiology, evolutionary biology and—in a somewhat different manner—the new discipline of psychology. Like so many authors in the late 19th century, Mach had extreme confidence in the methods of the natural sciences. However, this trait, often called scientism or positivism, can easily be used in polemical accounts that obscure other aspects of Mach’s thought. Mach is well-known for both his analysis of sensations and his evolutionary conception of perception and knowledge. The tension between the ambition to clarify the empirical basis of perception on the one hand and the focus on the natural origins of human perception on the other hand is, however, considerable. A comparison of these two perspectives can contribute to an ontological understanding of experience that sheds new light on the much-discussed topic of sense data and at the same time clarifies the difference between experience and observation and the role of experimental science in this context. In some respects, Mach seems closer to William James than to his followers in the Vienna circle. The accusation of idealism made by Lenin in his influential critique of positivism overlooks the implications of this naturalist approach but offers the occasion to dwell on the ontological implications of something that can be called natural historicity. Comparisons with Aristotle, Bacon, Descartes and Kant situate the empiricist theory of perception.