bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Penerapan Anggaran Berbasis Kinerja dan Pertanggungjawaban Belanja Terhadap Kualitas Laporan Akuntabilitas Kinerja Pegawai Instansi Pemerintah (LAKIP) Badan Pengelola Pajak dan Retribusi Daerah Pemerintah Kota Medan
Authors: Fauziah Fauziah
Published: June 2021

Penelitian ini dilakukan untuk menguji pengaruh penganggaran berbasis kinerja dan penerapan sistem pertanggungjawaban belanja terhadap kualitas laporan pertanggungjawaban kinerja instansi pemerintah daerah, instansi perpajakan dan penerimaan negara Kota Medan secara bersamaan. Sampel dalam Artikel ini adalah Pegawai Badan Pengelolaan Pajak dan Retribusi Daerah Pemerintah Kota Medan yang berjumlah 79 responden. Jenis data yang digunakan dalam Artikel ini adalah data mentah. Alat analisis yang digunakan dalam Artikel ini meliputi uji validitas dan reliabilitas alat Artikel, uji hipotesis klasik dan uji hipotesis dengan analisis linier berganda. Pengujian hipotesis membuktikan bahwa penerapan anggaran berbasis kinerja berdampak positif dan signifikan terhadap kualitas laporan akuntabilitas kinerja instansi pemerintah sampai batas tertentu, sedangkan pertanggungjawaban belanja secara parsial berpengaruh positif dan tidak signifikan terhadap Kualitas Laporan Akuntabilitas Kinerja Instansi Pemerintah Badan Pengelola Pajak dan Retribusi Daerah Pemerintah Kota Medan.
Pengaruh PAD, DAU, dan SILPA terhadap Perilaku Oportunistik Penyusunan Anggaran pada Pemerintahan Daerah Kabupatan dan Kota di Provinsi Sumatera Utara
Authors: Sitompul Novian Paisal
Published: June 2021

Penelitian ini bertujuan untuk menguji dan mengetahui pengaruh PAD, DAU dan SILPA terhadap perilaku oportunistik penyusunan anggaran pada pemerintahan daerah Kabupaten dan Kota Di Provinsi Sumatera Utara. Populasi dalam penelitian ini adalah seluruh pemerintahan daerah Kabupaten dan Kota Di Provinsi Sumatera Utara. Metode pengambilan sampel yang digunakan adalah purposive sampling. Berdasarkan kriteria sampel maka jumlah sampel dalam penelitian sebanyak 15 Kabupaten dan Kota Di Provinsi Sumatera Utara. Metode pengumpulan data dalam penelitian ini adalah menggunakan data sekunder. Data yang digunakan yaitu realisasi APBD yang meliputi PAD, DAU, SiLPA, belanja pendidikan, kesehatan, pekerjaan umum, hibah dan bantuan sosial tahun 2011–2016. Teknik analisis yang digunakan adalah analisis regresi berganda. Hasil penelitian menunjukkan bahwa PAD secara parsial tidak berpengaruh signifikan terhadap perilaku oportunistik penyusunan anggaran pada pemerintahan daerah Kabupaten dan Kota Di Provinsi Sumatera Utara. DAU secara parsial berpengaruh signifikan terhadap perilaku oportunistik penyusunan anggaran pada pemerintahan daerah Kabupaten dan Kota Di Provinsi Sumatera Utara. Silpa secara parsial berpengaruh signifikan terhadap perilaku oportunistik penyusunan anggaran pada pemerintahan daerah Kabupaten dan Kota Di Provinsi Sumatera Utara. PAD, DAU dan Silpa secara simultan berpengaruh signifikan terhadap perilaku oportunistik penyusunan anggaran pada pemerintahan daerah Kabupaten dan Kota di Provinsi Sumatera Utara.
Pengaruh Keputusan Investasi, Profitabilitas, Ukuran Perusahaan terhadap Nilai Perusahaan dengan Struktur Modal sebagai Variabel Intervening pada Perusahaan Properti dan Real Estate yang Terdaftar di BEI
Authors: Nasution Rizkya Paulita
Published: June 2021

Tujuan penelitian menganalisis apakah keputusan investasi, profitabilitas dan ukuran perusahaanberpengaruh terhadap nilai perusahaan dengan struktur modal sebagai variabel intervening pada Perusahaan Properti Dan Real Estate yang terdaftar di BEI. Data yang digunakan adalah laporan tahunan dari masing-masing perusahaan sampel, yang dipublikasikan melalui website www.idx.go.id. Metode analisis yang digunakan dalam penelitian ini adalah metode asosiatif, dengan pengujian asumsi klasik dan analisis jalur. Metode pengambilan sampel yang digunakan adalah puposive sampling dengan total sampel sebanyak 10 perusahaan Property & Real Estate yang terdaftar di BEI dan data dari tahun 2014 –2017. Hasil penelitian ini menunjukkan bahwa keputusan investasi tidak berpengaruh signifikan terhadap struktur modal. Profitabilitas dan ukuran perusahaanberpengaruh signifikan terhadap struktur modal pada Perusahaan Properti Dan Real Estate yang terdaftar di BEI, baik secara parsial dan simultan. Keputusan investasi berpengaruh signifikan terhadap nilai perusahaan. Profitabilitas, ukuran perusahaan dan struktur modal tidak berpengaruh signifikan terhadap nilai perusahaan pada Perusahaan Properti Dan Real Estate yang terdaftar di BEI. Keputusan investasi tidak berpengaruh terhadap nilai perusahaan dengan melalui struktur modal pada Perusahaan Properti Dan Real Estate yang terdaftar di BEI.Profitabilitasberpengaruh terhadap nilai perusahaan dengan melalui struktur modal pada Perusahaan Properti Dan Real Estate yang terdaftar di BEI. Ukuran perusahaan berpengaruh terhadap nilai perusahaan dengan melalui struktur modal pada Perusahaan Properti dan Real Estate yang terdaftar di BEI.
Studi Kepustakaan Penerapan Value Based Management Dalam Perusahaan
Authors: Sembiring Aprianta Raskami
Published: June 2021

Sekarang ini fokus dalam penciptaan nilai telah meningkat diseluruh dunia dalam beberapa tahun terakhir ini, kekuatan yang mendorong dibalik perubahan ini yaitu lingkungan yang lebih kompetitif dan aktivisme investor yang meningkat yang menyebabkan investor individu dan institusi mengharapkan tingkat kinerja yang lebih baik. Tujuan : Adapun tujuan dari penelitian ini untuk mengetahui penerapan value based management yang dilakukan perusahaan untuk memaksimalkan kekayaan pemegang saham. oleh sebab itu dalam rangka menciptakan nilai bagi pemegang saham, diperlukan pertumbuhan perusahaan dengan nilai tambah strategi pertumbuhan melebihi modal tambahan yang telah diinvestasikan oleh pemegang saham. Metodologi Penelitian : jenis penelitian yang digunakan peneliti adalah menggunakan penelitian studi kepustakaan dengan mengambil data dari buku, makalah atau artikel, jurnal dan sebagainya. Laporan penelitian ini disusun dengan prinsip kesederhanaan dan kemudahan karena mengingat keterbatasan kemampuan peneliti yang belum mampu melakukan kajian pustaka secara mendalam dan mendetail. Pembahasan : Value Based Management merupakan pendekatan untuk mengelola dimana perusahaan membangun, mempromosikan dan mempraktekkan nilai organisasi bersama. Economic Value Added merupakan penciptaan nilai bagi pemegang saham dengan elemen dasar capital employed, Financial Strategy Matrix merupakan matriks yang digunakan untuk membantu mengevaluasi dan mengendalikan keuangan perusahaan. Market Value Added digunakan untuk menilai sukses tidaknya perusahaan dalam menciptakan nilai bagi pemegang saham. Growth Value Map merupakan alat diagnosis yang digunakan untuk menaksir strategi dan menggambarkan strategi dalam penciptaan nilai. Kesimpulan : Pengukuran peningkatan kemakmuran pemegang saham yang paling langsung adalah harga pasar saham. jika harga saham mengalami peningkatan, maka kita akan mengatakan bahwa kemakmuran pemegang saham meningkat dan begitu juga sebaliknya.
KEDUDUKAN PERJANJIAN DALAM KITAB UNDANG-UNDANG HUKUM PERDATA DALAM SENGKETA KONSUMEN
Authors: Istiawati Sri
Published: June 2021

Penelitian ini bertujuan untuk mengetahui kedudukan perjanjian  dalam penyelesaian sengketa konsumen menurut Kitab Undang-Undang Hukum Perdata dan juga untuk memahami implementasi undang-undang tersebut di masyarakat. Adapun teknik yang digunakan dalam pengumpulan data melalui penelitian normatif, kemudian hasil data tersebut dianalisis menggunakan metode penelitian kepustakaan , kemudian hasil data tersebut dianalisis menggunakan metode kepustakaan dari berbagai buku, sumber bacaan, perundang-undangan. Selanjutnya dianalisis secara kualitatif. Kesimpulan  yang dihasilkan bahwa ditinjau dari aspek yuridis Kitab Undang-undang Hukum Perdata telah memberikan perlindungan hukum terhadap perjanjian konsumen di ranah sengketa konsumen, akan tetapi jika dilihat dari sisi implementasi peraturan tersebut, tujuan dari perlindungan konsumen menurut Kitab Undang-undang Hukum Perdata belum terlaksana dengan cukup baik sehingga masyarakat pada umumnya juga belum terlalu memahami kewajiban pelaku usaha untuk memberikan hak konsumen yang telah tercantum dalam peraturan perundang-undangan tersebut.
Respon Pemberian Pgpr (Plant Grwth Promoting Rhizobacteria) Dengan Dosis Dan Lama Perendaman Terhadap Pertumbuhan Mucuna Bracteata
Authors: Ardiansyah Irfan , Agustina Nur Ariyani
Published: June 2021

Penelitian ini memiliki tujuan untuk memahami dampak pertumbuhan Mucuna bracteata setelah pemberian PGPR (Plant Growth Promoting Rhizobacteria) dengan dosis dan waktu perendaman yang berbeda. Penelitian ini memanfaatkan metode eksperimental dengan rancangan acak kelompok pola faktorial. Faktor pertama adalah dosis PGPR dengan 4 taraf: 0 ml (K0), 5 ml (K1), 10 ml (K2), 15 ml (K2) dan faktor kedua adalah waktu perendaman dengan 4 taraf: 0 menit (P0), 30 menit (P1), 60 menit (P2), 90 menit (P3). Data dianalisis memanfaatkan sidik ragam (Analysis of Variance) dengan signifikan 5 %. Berdasarkan hasil analisa data yang diperoleh bahwa pemberian larutan PGPR memiliki dampak nyata atas jumlah daun, berat kering akar serta berat segar akar. Pemberian larutan PGPR dengan lama perendaman tidak menghasilkan dampak nyata atas berat kering akar, berat segar akar, berat kering tajuk, berat segar tajuk, jumlah daun, panjang sulur, jumlah daun, serta panjang akar. Interaksi antara pemberian larutan PGPR dan waktu perendaman tidak memiliki dampak nyata atas pertumbuhan Mucuna bracteata (berat kering akar, berat segar akar, berat kering tajing, berat segar tajuk, jumlah daun, panjang sulur, jumlah daun, serta panjang akar).
Treatment of direct oral anticoagulants in patients with liver cirrhosis and portal vein thrombosis
Authors: Chun Ho Soo , Choe A Reum , Lee Minjong , Cho Yuri , Kim Hwi Young , Yoo Kwon , Kim Tae Hun
Published: June 2021

Although patients with cirrhosis are known to be in a state of “rebalance” in that pro- and anticoagulant factors increase the risk for both bleeding and thrombosis, the prevalence of portal vein thrombosis (PVT) in patients with cirrhosis can be up to 26%. Therefore, physicians should consider anticoagulation for the prevention and management of PVT in patients with cirrhosis who are at high risk of PVT. Vitamin K antagonist or low molecular weight heparin is suggested as the standard treatment for PVT in cirrhosis. With the advent of new direct-acting oral anticoagulants (DOACs), there is a paradigm shift of switching to DOACs for the treatment of PVT in patients with cirrhosis. However, the safety and efficacy of DOACs in the treatment of PVT was not well-known in patients with cirrhosis. Therefore, this review focused on the current knowledge about the efficacy, safety concerns, and hepatic metabolism of DOACs in patients with cirrhosis and PVT.
AN EMPIRICAL STUDY FOR LIFE INSURANCES: A CASE STUDY OF PILIYANDALA REGION
Authors: Jads Lakshani , Nadn Napagoda
Published: June 2021

Life insurance is a very significant financial
contract due to uncertainty of human life. It pave the way
for policy holders to plan the future as their beneficiaries
safely. However, the insurance industry plays a huge role
in both private and public sector as a result of
globalization and commercialization. Therefore, a vital
competition is exists between private insurance companies
in order to expand their businesses all over the world and
to gain more profits. Hence, insurance companies often
tend to offer different modes of life insurances to gladden
customers. In the study, it has been considered the three
main life insurances which are; whole life insurance, Term
life insurance and Endowment life insurance. The aims of
this study are to explore the impact of various
demographic factors on customers life insurance
investment decision and predict policy holder’s behaviors.
This research is significant to understanding existing
market trends, develop new trading stations and facing
market competition. Multinomial logistics regression was
used to analyse the secondary data. The results of the quest
indicates that the age, marital status, monthly income,
gender, and monthly instalment are significant factors for
purchasing a life insurance. Furthermore, endowment life
insurance is the most efficient life insurance category in
Piliyandala region. However, the insurer is able to form
new explorations by conducting this research for other
regions
The Formation of Innovative Development Strategy in Competitive Environment of the Construction Industries
Authors: Kalmuratov B. , Bekturdiev M.
Published: June 2021

The article discusses the formation of development strategies for the construction industries. We study the determination of the implementation of the strategy of the construction industry, the dependence of the weight in the industry of the region, stages of its life cycle, the prediction of the development of the eco-world as a whole and the conjuncture of those segments commodity market, with which it is connected with the industrial-economic activity of these industries.
Development Trends of the Cement Industry in Uzbekistan
Authors: Khairova D. , Sayfullaeva M.
Published: June 2021

The article provides an overview and analysis of the cement industry in Uzbekistan. The authors analyzed the volume of construction work, the volume of production and sales of cement products on the exchange, as well as the target parameters of the production of cement products in 2019–2025. Particular attention is paid to the technological process of cement production, in particular dry and wet methods. The advantages and disadvantages of each production technology are presented in detail. The authors reviewed the existing and projected cement manufacturing enterprises in Uzbekistan.
Leading Activity of Young Children, as the Most Important Condition for Mental Development
Authors: Kachikeev T. , Kozhogeldiev A.
Published: June 2021

The importance of taking into account the leading type of activity in creating conditions for the mental development of children is confirmed by scientific research. The theoretical analysis of the study showed that early age is the basis for the further development of the child. The ability of an adult to regulate the cognitive activity of children determines their mental development. If the beginning of cognition is perception, but it is the manipulation of objects that is considered a condition for the development of thinking and speech. Actions with objects in joint activity with an adult help the child deeper cognition of reality. Studies show that in object-related actions, speech is stimulated in a child. Speech development at an early age leads to the better mental development of the child. The features of the leading activity at an early age have been proven by research by many scientists.
Internet Platform as a Didactic Means of Distance Learning Russian Literature
Authors: Asanalieva A.
Published: June 2021

The article is devoted to the problem of creating an Internet platform for teachers of Russian literature; such an Internet platform is considered by the author as an innovative didactic tool that performs all the functions of didactic tools and can be used for distance learning of Russian literature for a group of students; characterizing the available Internet platforms, we can conclude that the proposed options meet the needs of teachers of Russian literature.
Methods and Means Used in Forming the Preschoolers Musical Culture
Authors: Abdykadyrov A.
Published: June 2021

The article discusses information about effective methods and tools used in the formation of signs of musical culture of preschoolers. This should be carried out in a continuous process of education and upbringing. Therefore, it is widely stated that the methods and means set forth in the content of the article can be guided by the organization of each organized educational activity, the conduct of each educational event. As signs of the moral culture of preschoolers were taken: modesty, thrift, restraint, contentment, appropriate use, the tasks of moral education of preschoolers was determined.
Designing and Building the Brazilian Spoken English Learner (BraSEL) Corpus
Authors: Miranda Mateus
Published: June 2021

Despite the benefits to investigating learners' interlanguage through corpora, many are not compiled according to the Common European Framework of Reference (CEFR) levels, making it difficult to establish what learners can do at each stage. Furthermore, learners classify their English knowledge based on their years of experience, many times specifying an unattained level of proficiency. Much has been done on written corpora calibrated to CEFR, but research on calibrated spoken corpora is in its nascence. Taking into account the aforementioned considerations, the aim of this research is to compile the Brazilian Spoken English Learner (BraSEL) Corpus calibrated to the CEFR to further investigate, through a corpus pragmatics approach, what the development of spoken grammar and pragmatic features reveals across the levels. This poster will detail the planning phase of designing the corpus matrix, metadata information, and the task variables for the recording sessions.
Big Data in Sports: Predictive Models for Basketball Player's Performance
Authors: Lee Dae-Jin , Page Garritt L.
Published: June 2021

Aryuna is a platform that allows to perform advanced data analytics of men's professional basketball statistics of the last 16 seasons in more than 25 professional leagues and 71 FIBA tournaments. The complete database consists of more than 37,000 games and upwards of 20,000 players. Based on a historical database, the report aims to: characterize the performance curve, peak and optimal age in professional men's basketball using performance ratings of players in top basketball leagues; determine a rating correction factor for different basketball leagues, which accounts for intra-league and cross-league variability as well as for player characteristics (position, age, player ratings, etc.); determine which are the most important factors for predicting future outcomes of a basketball player.
Gambaran Pengetahuan dan Sikap Ibu Hamil tentang Pemberian ASI Eksklusif
Authors: Noya Fransisca , Nining Supriyani Maliusi  , Nurfatimah Nurfatimah , Longgupa Lisda Widianti , Entoh Christina
Published: June 2021

Introduction: Providing exclusive breastfeeding for the first six months old has many advantages both for baby and mother. Lack of mother knowledge concerning exclusive breastfeeding can affect the mother's attitude towards exclusive breastfeeding. Exclusive breastfeeding coverage in Tegalrejo Village in 2016 was 69%. It decreased in 2017 to 52%, then decreased again in 2018 to 44%. Exclusive breastfeeding coverage in Tegalrego Village has not fulfilled the Poso Regency Government standard which is 50%. This study aims to describe the knowledge and attitudes of pregnant women about exclusive breastfeeding. Methods: This research used descriptive quantitative method. The study population were all pregnant women who live in Tegalrejo Village totaling 33 mothers. The sample was taken using total sample technique. Results: from 33 respondents there were 20 respondents with good knowledge, and 28 respondents with positive attitude. Conclusion: It can be concluded that mainly respondents have a good knowledge and positive attitude towards exclusive breastfeeding
Pengaruh Pemeliharaan Kesehatan Mulut Ibu Hamil terhadap Status Tumbuh Kembang Janin
Authors: Vina Vina Dwi Wahyunita , Hermanses Sitti S.
Published: June 2021

Introduction: At Lorulun Public health Center, pregnant women who do Antenatal Care (ANC) visits with complaints around the mouth are still quite high (89.8%), and the implementation of health promotion for maintaining oral health during pregnancy is rarely carried out in a structured manner in conjunction with other pregnancy counseling activities. The aim to determine the effect of oral health maintenance in pregnant women on the growth and development of the fetus during pregnancy. Methods: This study is a quasi-experimental design with a non-equivalent control group design of two groups with a total sample of 64 respondents. Sampling was done using a purposive method. Data analysis of growth and development variable was carried out using independent t-test, oral hygiene variable was analyzed using Mann Whitney test and oral hygiene was analyzed using ANOVA test. Results: The results of this study showed that health education methods (video and demonstrations) were effective in increasing the average growth status of the fetus with TFU 28.06 (cm) TBJ 2334.69 grams and reducing the OHIS value of 1.26 (better oral hygiene), while oral hygiene was not affect the status of fetal growth and development. Conclusion: Oral hygiene does not affect the growth and development of the fetus, but it is hoped that pregnant women will continue to pay attention to their oral hygiene during pregnancy because oral hygiene affects the intake of nutritional needs that enter the fetus.
A Series of Efficient Umbrella Modeling Strategies to Track Irradiation-Mutation Strains Improving Butyric Acid Production From the Pre-development Earlier Stage Point of View
Authors: Cao Li , Gao Yue , Wang Xue-Zhen , Shu Guang-Yuan , Hu Ya-Nan , Xie Zong-Ping , Cui Wei , Guo Xiao-Peng , Zhou Xiang
Published: June 2021

Clostridium tyrobutyricum (C. tyrobutyricum) is a fermentation strain used to produce butyric acid. A promising new biofuel, n-butanol, can be produced by catalysis of butyrate, which can be obtained through microbial fermentation. Butyric acid has various uses in food additives and flavor agents, antiseptic substances, drug formulations, and fragrances. Its use as a food flavoring has been approved by the European Union, and it has therefore been listed on the EU Lists of Flavorings. As butyric acid fermentation is a cost-efficient process, butyric acid is an attractive feedstock for various biofuels and food commercialization products. 12C6+ irradiation has advantages over conventional mutation methods for fermentation production due to its dosage conformity and excellent biological availability. Nevertheless, the effects of these heavy-ion irradiations on the specific productiveness of C. tyrobutyricum are still uncertain. We developed non-structured mathematical models to represent the heavy-ion irradiation of C. tyrobutyricum in biofermentation reactors. The kinetic models reflect various fermentation features of the mutants, including the mutant strain growth model, butyric acid formation model, and medium consumption model. The models were constructed based on the Markov chain Monte Carlo model and logistic regression. Models were verified using experimental data in response to different initial glucose concentrations (0–180 g/L). The parameters of fixed proposals are applied in the various fermentation stages. Predictions of these models were in accordance well with the results of fermentation assays. The maximum butyric acid production was 56.3 g/L. Our study provides reliable information for increasing butyric acid production and for evaluating the feasibility of using mutant strains of C. tyrobutyricum at the pre-development phase.
Selective Complex Precipitation for Ferro-Chrome Separation From Electroplating Sludge Leaching Solution
Authors: Jinhui Li , Ying Wang , Yudong Wang , Yang Gao , Yang Yang , Ruixiang Wang
Published: June 2021

In this paper, aiming at the problem of chrome-iron separation in electroplating sludge, the separation of ferrochrome by complexation and precipitation with benzoic acid as complexing agent is achieved. The optimal conditions consisted of a 1: 3 molar ratio of Fe3+: C6H5COOH, a reaction temperature of 30°C, a final pH of 2.5 and a reaction time of 2 min. The separation rate of the iron was 97.38% and the rate of loss of chromium was only 3.59%. The ferrochromium separation products were analyzed by XRD, fluorescence spectroscopy, infrared spectroscopy and H NMR Spectroscopy in order to study the mechanism of precipitation. The results showed that benzoic acid preferentially forms a complex with iron and iron benzoate precipitates with an increase pH. The iron benzoate crystals have a fine particle size, settle rapidly and are easy to filter. The separation of Cr 3+/Fe3+ was successful using our methodology.
Taxonomic Characterization and Short-Chain Fatty Acids Production of the Obese Microbiota
Authors: Martínez-Cuesta M. Carmen , del Campo Rosa , Garriga-García María , Peláez Carmen , Requena Teresa
Published: June 2021

Intestinal microbiota seems to play a key role in obesity. The impact of the composition and/or functionality of the obesity-associated microbiota have yet to be fully characterized. This work assessed the significance of the taxonomic composition and/or metabolic activity of obese- microbiota by massive 16S rRNA gene sequencing of the fecal microbiome of obese and normoweight individuals. The obese metabolic activity was also assessed by in vitro incubation of obese and normoweight microbiotas in nutritive mediums with different energy content. We found that the microbiome richness and diversity of the two groups did not differ significantly, except for Chao1 index, significantly higher in normoweight individuals. At phylum level, neither the abundance of Firmicutes or Bacteroidetes nor their ratio was associated with the body mass index. Besides, the relative proportions in Collinsella, Clostridium XIVa, and Catenibacterium were significantly enriched in obese participants, while Alistipes, Clostridium sensu stricto, Romboutsia, and Oscillibacter were significantly diminished. In regard to metabolic activity, short-chain fatty acids content was significant higher in obese individuals, with acetate being the most abundant followed by propionate and butyrate. Acetate and butyrate production was also higher when incubating obese microbiota in mediums mimicking diets with different energy content; interestingly, a reduced capability of propionate production was associated to the obese microbiome. In spite of the large interindividual variability, the obese phenotype seems to be defined more by the abundance and/or the absence of distinct communities of microorganism rather than by the presence of a specific population.
Case Report: Isolate Congenital Coronary Artery Fistula With Giant Artery Aneurysm in a Neonate
Authors: Yuan Haoyong , Wu Zhongshi , Wu Qin , Lu Ting , Tang Yilun , Huang Can
Published: June 2021

A rare case of neonatal congenital coronary artery, right ventricle fistula with giant coronary artery aneurysm formation, was reported. Computed tomography angiography demonstrated the dilated and tortuous tunnel arising from the right aortic sinus and traversing the epicardial surface before opening into the anterolateral aspect of the RV. Successful surgical repair was performed with a patch closure of the fistula and coronary angioplasty. The postoperative recovery was uneventful. Our experience of this rare congenital heart disease demonstrated that early surgical repair of coronary artery fistula and coronary angioplasty in the neonate can be performed safely. Further study is needed to seek the basis on this.
Case Report: Morphological Characterization and Long-Term Observation of Bilateral Sequential Internal Mammary Artery Aneurysms in a Patient With Confirmed FBN1 Mutation
Authors: Stengl Roland , Ágg Bence , Szilveszter Bálint , Benke Kálmán , Daradics Noémi , Ruskó Bernadett , Vattay Borbála , Merkely Béla , Pólos Miklós , Szabolcs Zoltán
Published: June 2021

Marfan syndrome (MFS) is a genetically determined connective tissue disorder that leads to ocular, skeletal, and severe cardiovascular involvement. High mortality of MFS is associated with aortic dissection and aneurysm characteristic to the syndrome. In MFS, only a few cases of peripheral arterial involvement have been reported so far, mostly without a genetically confirmed diagnosis. We report a 41-year-old MFS patient with a saccular pearl-string-like aneurysm on the right internal mammary artery (RIMA) and a single aneurysm on the left internal mammary artery (LIMA). To our knowledge this is the first reported case on internal mammary artery aneurysms with this special morphology and with follow-up and blood pressure control as primary therapeutic approach in a patient with genetically confirmed MFS. The aneurysms with the above described morphology first appeared as small aneurysms on a CT scan 6 years after a cardiac operation. Due to the lack of guidelines, based on the asymptomatic state of the patient, the increased tortuosity of the affected vessels and the history of prior cardiac surgery, we decided to closely monitor these aneurysms with blood pressure control and without carrying out any interventions. On the CT scans done 3, 11, 12, 17, and 32 months after identifying the aneurysms, no progression of these structures was detected. Our findings confirm the possibility of the occurrence of internal mammary artery aneurysms in patients with FBN1 mutation and we believe that monitoring these aneurysms with blood pressure management can be a suitable option in selected cases.
Water Vapor Changes Affect Cross-Seasonal Strong Drought Events in the Eastern Region of Northwest China
Authors: Zhang Yu , Liu Kang , Li Yaohui , Shen Wei , Ren Yulong , Zeng Dingwen , Sha Sha
Published: June 2021

Drought in eastern Northwest China (ENC) is severely affected by water vapor conditions. An in-depth study of the primary sources of water vapor and its characteristics, at intraseasonal and interannual timescales, was conducted. This information is crucial for further study of the causes and mechanisms of extreme droughts and floods in the ENC. This study evaluated the spatial distribution and transport characteristics of water vapor over ENC during the 1981–2019 period based on the fifth generation of the European Center for Medium-Range Weather Forecasts atmospheric reanalyzes data of the global climate (ERA5). We studied the water vapor transport routes, water vapor convergence, water vapor budgets as well as the changes in water vapor fluxes and budgets over time in four areas surrounding ENC. The Mediterranean Sea, Black Sea, Caspian Sea, Indian Ocean, Bay of Bengal, and the South China Sea were the main sources of water vapor in ENC, supplemented by mid to high-latitude continental sources. The monthly change in water vapor flux in ENC exhibited the peak on July. The transport of water vapor in ENC was mainly toward the east and north. For most cross-seasonal drought events, the water vapor output is the main way in the south boundary and the west boundary. However, for the longest duration of cross-seasonal strong drought events, it is characterized by that the water vapor output is the main way in the south boundary, while the water vapor input in the north boundary is obviously weak. Water vapor paths in cross-seasonal strong drought events are analyzed, by which the Hybrid Single-Particle Lagrangian Integrated Trajectory model (HYSPLIT). The intensity of the subtropical high in the western Pacific is weak and the position is south, which corresponds to the occurrence of cross-seasonal strong drought in the ENC.
Specialization for Tachinid Fly Pollination in the Phenologically Divergent Varieties of the Orchid Neotinea ustulata
Authors: Martel Carlos , Rakosy Demetra , Dötterl Stefan , Johnson Steven D. , Ayasse Manfred , Paulus Hannes F. , Nilsson L. Anders , Mejlon Hans , Jersáková Jana
Published: June 2021

Despite increased focus on elucidating the various reproductive strategies employed by orchids, we still have only a rather limited understanding of deceptive pollination systems that are not bee- or wasp-mediated. In Europe, the orchidNeotinea ustulatahas been known to consist of two phenologically divergent varieties, neither of which provide rewards to its pollinators. However, detailed studies of their reproductive biology have been lacking. Our study aimed to characterize and understand the floral traits (i.e., morphology, color, and scent chemistry) and reproductive biology ofN. ustulata. We found that the two varieties differ in all their floral traits; furthermore, whileNeotinea ustulatavar.ustulataappears to be pollinated by both bees (e.g.,Anthophora,Bombus) and flies (e.g.,Dilophus, Tachina), var.aestivalisis pollinated almost entirely by flies (i.e.,Nowickia, Tachina). Tachinids were also found to be much more effective than bees in removing pollinaria, and we show experimentally that they use the characteristic dark inflorescence top as a cue for approaching inflorescences. Our results thus suggest that while bothN. ustulatavarieties rely on tachinids for pollination, they differ in their degree of specialization. Further studies are, however, needed to fully understand the reproductive strategy ofN. ustulatavarieties.
Immune Thrombocytopenia Revealing Enriched IgG-4 Peri-Renal Rosai-Dorfman Disease Successfully Treated with Rituximab: A Case Report and Literature Review.
Authors: Razanamahery Jerome , Humbert Sebastien , Emile Jean-Francois , Cohen-Aubart Fleur , Fontan Jean , Maksud Philippe , Audia Sylvain , Haroche Julien
Published: June 2021

Immune thrombocytopenia (ITP) is a rare autoimmune-mediated condition characterized by isolated thrombocytopenia (<100 G/L) after exclusion of other causes. Mostly primary, it is associated with hematological malignancy, autoimmune disorders, or infection in 20% of patients. It is exceptionally described in patients with histiocytosis, mostly in children (seven patients in literature). We report a case of a 69-year-old man with ITP leading to the diagnosis of histiocytosis. At ITP's diagnosis, the patient had elevated gamma-globulins leading to computed tomography showing bilateral peri-renal infiltration. The biopsy showed enriched IgG-4 peri-renal Rosai Dorfman disease withMAP2K1mutation, although peri-renal infiltration is highly suggestive of Erdheim-Chester disease. This overlapping association was described in men with mutation inMAP2K1gene. Macrophages are implicated in the pathophysiology of ITP in multiple ways, notably by the phagocytosis of opsonized platelets and their function of antigen-presenting cells able to stimulate autoreactive T cells. Histiocytic cells derivate from monocyte-macrophage lineage. Activation of macrophages in active histiocytosis is responsible for consequential platelet destruction in ITP associated histiocytosis. Finally, this case highlights a rare presentation of ITP revealing histiocytosis, both being efficiently treated with rituximab.
Glutamic Acid Transporters: Targets for Neuroprotective Therapies in Parkinson’s Disease
Authors: Li Xiang , Wang Wenjun , Yan Jianghong , Zeng Fancai
Published: June 2021

Parkinson’s disease (PD) is a common neurodegenerative disease in middle-aged and elderly individuals. At present, no effective drug has been developed to treat PD. Although a variety of drugs exist for the symptomatic treatment of PD, they all have strong side effects. Most studies on PD mainly focus on dopaminergic neurons. This review highlights the function of glutamic acid transporters (GLTs), including excitatory amino acid transporters (EAATs) and vesicular glutamate transporters (VGLUTs), during the development of PD. In addition, using bioinformatics, we compared the expression of different types of glutamate transporter genes in the cingulate gyrus of PD patients and healthy controls. More importantly, we suggest that the functional roles of glutamate transporters may prove beneficial in the treatment of PD. In summary, VGLUTs and EAATs may be potential targets in the treatment of PD. VGLUTs and EAATs can be used as clinical drug targets to achieve better efficacy. Through this review article, we hope to enable future researchers to improve the condition of PD patients.
Decreased MEF2A Expression Regulated by Its Enhancer Methylation Inhibits Autophagy and May Play an Important Role in the Progression of Alzheimer’s Disease
Authors: Li Hui , Wang Feng , Guo Xuqi , Jiang Yugang
Published: June 2021

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques and neurofibrillary tangles which significantly affects people’s life quality. Recently, AD has been found to be closely related to autophagy. The aim of this study was to identify autophagy-related genes associated with the pathogenesis of AD from multiple types of microarray and sequencing datasets using bioinformatics methods and to investigate their role in the pathogenesis of AD in order to identify novel strategies to prevent and treat AD. Our results showed that the autophagy-related genes were significantly downregulated in AD and correlated with the pathological progression. Furthermore, enrichment analysis showed that these autophagy-related genes were regulated by the transcription factor myocyte enhancer factor 2A (MEF2A), which had been confirmed using si-MEF2A. Moreover, the single-cell sequencing data suggested that MEF2A was highly expressed in microglia. Methylation microarray analysis showed that the methylation level of the enhancer region of MEF2A in AD was significantly increased. In conclusion, our results suggest that AD related to the increased methylation level of MEF2A enhancer reduces the expression of MEF2A and downregulates the expression of autophagy-related genes which are closely associated with AD pathogenesis, thereby inhibiting autophagy.
The Association Between Vitamin E Deficiency and Critically Ill Children With Sepsis and Septic Shock
Authors: Dang Hongxing , Li Jing , Liu Chengjun , Xu Feng
Published: June 2021

Background: Literature is scarce on the assessment of vitamin E status in septic children. We aim to investigate the prevalence of vitamin E deficiency in critically ill children with sepsis and septic shock and its association with clinical features and outcomes.

Methods: We compared serum vitamin E status between the confirmed or suspected infection and no infection groups, the sepsis shock and no sepsis shock groups upon pediatric intensive care unit admission. Clinical characteristics were compared in subgroup patients with and without vitamin E deficiency. The association between vitamin E deficiency and septic shock were evaluated using univariate and multivariable methods.

Results: 182 critically ill children with confirmed or suspected infection and 114 without infection were enrolled. The incidence of vitamin E deficiency was 30.2% in the infection group and 61.9% in the septic shock subgroup (P < 0.001). Thirty-days mortality in critically ill children with vitamin E deficiency was significantly higher than that without vitamin E deficiency (27.3 vs. 14.2%, P < 0.05). Vitamin E levels were inversely associated with higher pediatric risk of mortality (r = − 0.238, P = 0.001) and cardiovascular sequential organ failure assessment (r = −0.249, p < 0.001) scores in critically ill children with infection. In multivariable logistic regression, vitamin E deficiency showed an independent effect on septic shock (adjusted OR: 6.749, 95%CI: 2.449–18.60, P < 0.001).

Conclusion: Vitamin E deficiency is highly prevalent in critically ill children with sepsis and contributed to the septic shock.
Affective States, Coping and Mutual Understanding in Russian Families During the Coronavirus Disease 2019 Pandemic Lockdown
Authors: Leonova Elena V. , Khavylo Alexey V.
Published: June 2021

The purpose of the empirical study (April–May 2020) was to determine the type and level of affect, specifics of coping styles during the coronavirus disease 2019 (COVID-19) pandemic lockdown, as well as mutual understanding between parents and children. We hypothesized that the combination of positive and negative affect magnitude is a factor in well-being and mutual understanding with children, as well as the coping style during the lockdown. The study involved 705 respondents aged 16–77, including 435 parents living with children under 16. Personal traits, positive and negative affect, coping styles, and well-being were studied by Ten-Item Personality Inventory (TIPI)-RU, Positive and Negative Affect Scale (PANAS)-RU, Brief COPE, Satisfaction with Life Scale (SWLS), respectively. Mutual understanding was studied using a self-report questionnaire. Cluster analysis (k-means method) was used to divide the sample into clusters in accordance with the combination of positive and negative affect. According to the data obtained, parents from the “positive-affective” cluster have much better mutual understanding with both younger and older children than participants from other clusters.
Evaluation of Sensitization Program on Occupational Health Hazards for Nursing and Allied Health Care Workers in a Tertiary Health Care Setting
Authors: Naithani Manisha , Khapre Meenakshi , Kathrotia Rajesh , Gupta Puneet Kumar , Dhingra Vandana Kumar , Rao Shalinee
Published: June 2021

Background: Occupational health hazard pertaining to health care providers is one of the neglected areas that need serious attention. Any compromise in their safety would result in reduction in workforce, which may affect patient care, keeping in mind the wide gap between the required number and actual health care workers (HCWs) available in the world over.

Aim: This study was undertaken to evaluate the change in knowledge through a sensitization training program on occupational health hazards and vaccination for HCWs.

Materials and Methods: Participants of the study included nursing and allied HCWs of a tertiary care health institute in Uttarakhand, India. Multiple training sessions, each of around 180 min, were held periodically in small groups with 20–40 participants over 2 years. Participants were assessed with pretest and posttest questionnaires, and feedback was taken. Questionnaires comprised three categories: general safety and ergonomics, biological hazards, and chemical and radiation hazards. Data of incident reporting for needlestick injury from 2017 to 2019 were retrieved. All data were compiled in Excel sheet and analyzed.

Results: A total of 352 participants were included in the study. Mean ± SD for pretest and posttest scores were 5.3 ± 2.13 and 11.22 ± 2.15, respectively. There was considerable improvement in knowledge, which was found to be statistically significant with p-value of 0.001 for all categories. Participants in their feedback suggested for inclusion of psychosocial aspect in further training programs.

Conclusion: Low baseline knowledge prior to attending the course highlights a need for an intervention through such structured sensitization program to create awareness and educate HCWs on common occupational health hazards and vaccination. Statistically significant improvement in posttest knowledge highlights effectiveness of the training program. A drastic rise in incident reporting for needlestick injury reflects fairly good impact of training program. Regular and appropriate form of training can reduce injuries resulting from occupational hazards and ensure healthy workforce contributing toward a positive impact on national economy.
Formulation and investigation of turmeric extract and sodium benzoate loaded capsules
Authors: Bácskay Ildikó , Sinka Dávid , Józsa Liza , Vasas Gábor , Ujhelyi Zoltán , Fehér Pálma , Juhász Béla , Szilvássy Zoltán
Published: June 2021

Turmeric has been studied and used as a plant derivate active ingredient for centuries. Several effects of turmeric have been described, however the poor solubility of its active ingredients during the formulation development may limit oral applicability. The aim of research was to involve the development of a dietary supplement of a hard capsule containing turmeric (Curcuma longa) (ground powder from the root standardized to curcuminoid content) and sodium benzoate. The manufacturing technology and the analytic method of the formulation have been developed. Formulation studies according to the Ph. Hg. VIII. standards have been performed. The product may have insulin sensitizing and memory enhancing effects, related animal studies are ongoing.
Conceptual Design of Electromechanical Actuation Systems for Large-Sized Directional Control Valves
Authors: Vonderbank Tobias , Schmitz Katharina
Published: June 2021

Increasing performance in modern hydraulics is achieved by a close investigation of possible enhancements of its components. Prior research has pointed out that electromechanical actuators can form suitable alternatives to hydraulically piloted control systems. Since the requirements at these actuation systems depend on the operating conditions of the system, each actuator can be optimized to the respective hydraulic system. Considering that many different conceptual designs are suitable, the phase of conceptual design plays a decisive role during the design process. Therefore, this paper focuses on the process of developing new conceptual designs for electromechanical valve actuation systems using the method of function structures. Aiming to identify special design features, which need to be considered during the design process of electromechanical actuation systems, an exemplary actuator was designed based on the derived function structure. To highlight the potential of function structures for the development of new electromechanical valve actuation systems, two principal concepts, which allow the reduction of the necessary forces, have been developed by extending the function structure. These concepts have been experimentally investigated to identify their advantages and disadvantages.
RedEfish: Generation of the Polycistronic mScarlet: GSG-T2A: Ttpa Zebrafish Line
Authors: Head Brian , La Du Jane , Barton Carrie , Zhang Jie , Wong Carmen , Ho Emily , Tanguay Robyn L. , Traber Maret G.
Published: June 2021

The vitamin E regulatory protein, the alpha-tocopherol transfer protein (Ttpa), is necessary for zebrafish embryo development. To evaluate zebrafish embryo Ttpa function, we generated a fluorescent-tagged zebrafish transgenic line using CRISPR-Cas9 technology. One-cell stage embryos (from Casper (colorless) zebrafish adults) were injected the mScarlet coding sequence in combination with cas9 protein complexed to single guide RNA molecule targeting 5′ of the ttpa genomic region. Embryos were genotyped for proper insertion of the mScarlet coding sequence, raised to adulthood and successively in-crossed to produce the homozygote RedEfish (mScarlet: GSG-T2A: Ttpa). RedEfish were characterized by in vivo fluorescence detection at 1, 7 and 14 days post-fertilization (dpf). Fluorescent color was detectable in RedEfish embryos at 1 dpf; it was distributed throughout the developing brain, posterior tailbud and yolk sac. At 7 dpf, the RedEfish was identifiable by fluorescence in olfactory pits, gill arches, pectoral fins, posterior tail region and residual yolk sac. Subsequently (14 dpf), the mScarlet protein was found in olfactory pits, distributed throughout the digestive tract, along the lateral line and especially in caudal vertebrae. No adverse morphological outcomes or developmental delays were observed. The RedEfish will be a powerful model to study Ttpa function during embryo development.