bluuebunny/crossref_metadata_2025 huggingface dataset:
Forms of Existence of Literary History and Criticism in Spanish Literature of 15–16th Centuries
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Ershova Irina V. ,   The Russian Presidential Academy of National Economy and Public Administration
Published: July 2022

The insights into consistency of literary traditions, ancient authors of authority, and so-called “role models” rather frequently appeared in the prologues and texts of the late Middle Ages and Renaissance. All of them are associated with development of poetological thought: the first national poetics and rhetoric are emerging and a whole host of other forms of systemizing the past and existing literary processes come into being. This paper is devoted to some forms and examples of such a kind of classifications (prologue, literary catalogue) and, in particular, we are interested in the attempts of grouping the names by these or other criteria and contemplate consistency in various kinds of traditions rather than simply giving the assessment of the talent and properties of the literary figures. These are the constructions that enable us to consider Marqués de Santillana, Cervantes, and Lope de Vega the first “literature historians”.
The History of Icelandic Literature as a Subject of Art Work
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Korovin Andrey V.
Published: July 2022

The article deals with the problem of acceptance of the national literature as an important and unique phenomenon by Icelanders in the beginning of 20th century, but in our days it is a major part of the Icelandic national self-conscience. The development of Icelandic nation is strictly connected to the literary tradition started in Middle Ages; there was a paradox situation, when the modern Icelandic society did not have any serious interest to the national heritage and the Old Norse books. The most prominent Icelandic philologist Sigurður Nordal made the influentional changes in the social perception of the literary tradition. He was an author of several volumes on Icelandic literature, the most important of them is “Icelandic Culture”. His main goal was to show Icelandic literature as a significant and outstanding part of European culture, to connect the Old Norse tradition with the modernity: he brought to academic texts the elements of fiction. The world-wide known Icelandic writer Halldór Laxness had the same aims in his novels “World Light” and “Iceland’s Bell”. The Icelandic literature in these texts is presented in its development, in the past and present, and became the subject of narration.
Francesco Fulvio Frugoni’s “The Tribunal of Criticism”. The Critical View on the Literature of the 17th Century
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Patronnikova Yulia S.
Published: July 2022

The article looks at the critical analysis of the 17th-century literature carried out by Francesco Fulvio Frugoni in his life’s main opus, “Il Cane di Diogene” (“The Dog of Diogenes”, 1687–1689) — or, more, precisely, in its most famous, tenth novel “Il Tribunal della Critica” (“The Tribunal of Criticism”). The critical evaluation of the authors and their works has an allegorical form of the tribunal of the Criticism over the books. It takes place in Apollo’s temple on Mount Parnassus, where the opus’s main hero — dog Saetta owned by the Cynic philosopher Diogenes — arrives to after a long period of wandering. The tribunal evaluates typologically different works, for the most part, written in Roman languages in the first half of 17th century — presumably the author shares the knowledge he acquired while studying and travelling. A number of famous figures of Seicento are thus left out of consideration. The key criterion used in the evaluation of a text is the ratio of the pleasant and the useful in it. The pleasant refers to a text’s being written in a flamboyant style and the useful — to its containing a certain message or idea. For all the shortcomings of the baroque authors, Frugoni takes his age to be exemplary. Despite its incompleteness and partiality, Frugoni’s analysis is an important source of information about Seicento literature, as well as Seicento theory of literature. In addition, being an analysis of literary texts, it contributes to the development of the history of literature as a self-standing discipline.
Edmund Gosse and the History of English Classical Poetry:Science or Art?
Authors: Sloistova Maria S.
Published: July 2022

The present paper focuses on the history of the rise of classical poetry in the17th century England by Edmund Gosse, the outstanding British 19th century critic, writer and poet. The author aims at analyzing Gosse’s work as a scientific monograph, on the one hand, and fiction, on the other hand. In his history of the rise of English classical poetry Gosse sheds light upon the life and work of twelve poets: E. Waller, J. Denham, W. Davenant, A. Cowley, S. Godolphin, J. Cleveland, R. Wild, W. Chamberlayne, T. Stanley, H. Vaughan, A. Marvell, J. Dryden. The paper deals with the scientific methods used by Gosse in his work and its fictional elements such as his personal point of view, a variety of stylistic devices, etc. The author of the present paper draws a conclusion on the combination and interaction of a work of science and that of fiction in Gosse’s book.
“History of Polish Literature” by Stanislav Tarnowski
Authors:   Institute of Literature and Linguistics, Jan Kochanowski University, Krzystofik Malgorzata
Published: July 2022

The History of Polish Literature (1900–1907) by Stanislaw Tarnowski (1837–1917) was written in a rhetorical style, emotional, subjective in judgments, it is an interpretation of the political, moral, aesthetic and religious views of the author. As the flagship of literary research of its time, it continues to be one of the most important historical and literary surveys of Polish literature. This work is the crown of Tarnovsky’s many years of scientific activity. It is based on previous publications and lectures given at the Jagiellonian University. According to Tarnowski, the essence of literary history is to show the history of literature in changes, turns, and the reasons for these turns. Tarnowski’s work is an expression of a positivist historical and literary consciousness that emphasizes the close relationship between literature and historical and cultural change, as well as the political situation. In chronological order, the author describes various areas of Polish literature. In addition to fiction, it also discusses epistolography, biography, religious and philosophical literature, and historiography. The History of Polish Literature became Tarnowski’s contribution to the struggle to preserve Polish national identity. For many generations of Poles, it was a textbook on the literature, culture and history of Poland.
The Principle of Interest in the “History of Russian Literature” by A.I. Nezelenov
Authors:   Kemerovo State University, Nalegach Natalya V.
Published: July 2022

At the turn of the 19th–20th centuries in connection with the reform of education and the dispute about its two models — classical and real — there was not only a revision of the curricula of gymnasiums, pregymnasiums and real schools, but also changes in approaches to the compilation of educational books and sets. This also affected such fundamental disciplines as the History of Russian Literature. Among the proposed new concepts of the textbook on the discipline, the experience of prof. A.I. Nezelenov, who based his vision of the course on the idea of involving gymnasium students in educational and subsequently scientific work by rejecting dryness of presentation in the direction of entertaining text. At the same time, an important moment is the harmonious combination of the principles of entertainment and science, which was achieved in following the historical, literary and biographical approaches when building a cross-cutting “plot” of the textbook through designating the goal of studying the discipline as comprehending the spiritual experience and development of the Russian people, expressed in the life and work of outstanding poets, the most significant of which, according to A.I. Nezelenov, are A.S. Pushkin and N.V. Gogol. The principle of interest, implemented in the textbook supposed handling to such new at that time forms of exposition in text as the combination of a historical and literary fact with its imaginary drawing through in the form of attributing to the people or to the described by him authors certain thoughts and feelings by creating the works examining in the textbook. The retelling of works of art contributes to the same principle, which, as a rule, was used not in the textbook itself, but in the anthology that came with it. Finally, it should be noted that A.I. Nezelenov tried to change the functional content of the textbook not as a text for memorization, but as a book that contributes to a combination of rational and emotional perception by the student in order to arouse interest in the subject and encourage independent work. These properties can be seen in the textbook on “History of Russian Literature”, prepared by prof. A.I. Nezelenov, the attitude towards the synthesis of science and art, realized in the pedagogical activity of the scientist and characteristic of the culture of the turn of the 19th–20th centuries as a whole.
The “Speculum historiale” of Vincent of Beauvais: from the History of Antiquity to the History of Ancient Literature
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Evdokimova Ludmila V. ,   Saint Tikhon’s Orthodox University
Published: July 2022

The Speculum Historiale” — the fourth volume of the encyclopaedia of Vincent of Beauvais, called the “Speculum majus” — comprises a narrative of world history from the creation of the world to the middle of the 13th century. In the chapters of “The Speculum Historiale”, which refer to ancient authors, Vincent depends heavily on the second part of the chronicle of Eusebius of Caesarea, preserved in the Latin translation by Jerome. Using the chronology of this work and also numerous mentions of ancient authors by Eusebius, Vincent and his collaborators supplemented these elements with excerpts from other books and integrated all of them into the volume of “The Speculum Historiale”. Thus, the volume comprises a great variety of materials having either a direct or sometimes indirect relation to literature. Writers, philosophers, other authors appeared as individuals significant in the history; their works became equal in importance to the principal historical events. Materials related to literature or culture form separate chapters, or a series of chapters: the history of culture is presented as part of history in the broad sense of the word, without completely coinciding with it. The article discusses the sources of chapters about Aesop and some other Greek poets, as well as Horace, Virgil, Plautus and Terence. These texts can be divided into three groups: some of them met the needs of Dominican preachers, they were processed according to Christian guidelines; others conveyed the testimonies of earlier ancient writers, which have not lost their significance today. And the third group transmitted medieval ideas about some authors and genres. This diverse material and the place that it occupied in “The Speculum Historiale” allows us to trace how the contours of the history of literature become discernible in the framework of history. A few centuries later, in the first volume of the “Histoire littéraire de la France” (1733), the same contours become more apparent: although the history of literature acquires the status of an independent discipline here, its close connection with history determines both the general purpose of the book and the content of many chapters.
“American Lectures” Of Italo Calvino: Six Memos for the Next Millenium
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Saburova Ludmila E.
Published: July 2022

The course of the so-called “American Lectures” prepared by Italo Calvino became the last literary work of the writer and is rightfully considered his testament. Calvino himself addresses the text to posterity, collecting in his lectures the valuable properties of literature to be preserved for the next millennium. In the era of continuous flow of information, often consisting of formulaic texts and images that have literally flooded the entire media space, Calvino warns readers about the danger looming over such a distinctive and original kind of human activity as literature. The writer seeks to talk about the special role of literature and to build its unique qualities into the perspective of the development of the rapidly changing world. The categories that gave names to the five lectures are far from generally accepted literary terminology. Moreover, the writer’s reflections go beyond both the history of literature and traditional poetics and aesthetics. Calvino’s view of literature is devoid of dogmatism and is extremely original. Analyzing different phenomena, the writer draws unexpected parallels between literary works of different countries and eras. Taking Calvino’s frame of reference as the starting point, the reader becomes a full participant in the process, unwittingly continuing to mentally string new names and works on the connecting thread discovered by the writer. The alternative theory and history of literature proposed by the writer has become an unquestionable bestseller not only among specialists, but also among the general public.
The Treatise of the Buddhist Monk Shinkei Sasamegoto (“Murmured Conversations, 1463–1464”) on the Poetry of Renga (“linked stanzas”) as a Piece of Art
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Dyakonova Elena M. ,   Institute for Oriental and Classical Studies
Published: July 2022

Medieval treaties about classical Japanese poetry can be classified in two large groups: the ‘books of rules” (shikimoku) and texts on the theory of poetry (ronbun), which were related to religious and philosophical tractates. The latter are important as a source of knowledge about complex system of literary genres in Japan, for which they set up formal and quality standards. Ronbun treaties also introduced an image of an ideal author and described a certain code of conduct for a medieval poet. This article focuses on a treaty about renga (‘linked stanzas’) poetry Murmured conversations (Sasamegotо, 1463–1464) composed by the Buddhist monk and writer Shinkei, and representative of several centuries of Chinese and Japanese poetic theory. The treaty is written in a literary form of a dialogue between a master and a provincial disciple, which was characteristic for the late Medieval period. It offers a variety of references to the most important texts of the literary tradition as well as multiple direct and indirect quotes from prosaic and poetic oeuvres of the time. This article includes the translation of several fragments of the treaty.
Hesiod’s dream: the History of World Literature in the Novel of French Précieuse (“Clélie, l’histoire romaine” by Madeleine de Scudéry)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Golubkov Andrey V.
Published: July 2022

The research focuses on the annotated translation into Russian language of the Hesiod’s Dream, large fragment from the 2nd book of the 8th volume of the novel “Clélie, l’histoire romaine” of the French writer of the middle of the 17th century Madeleine de Scudéry, which is a consistent narration about the world history of the literature in Ancient Greece, Ancient Rome, Renaissance Italy, as well as in France from the late Middle Ages up to the 1650’s. The introductory article analyzes the metatextual nature of the narrative (it is presented as the reading of a manuscript by the heroes of the novel, which tells about Hesiod, to whom the muse of poetry Calliope tells the future development of literature), as well as the context of the creation of an episode that reflected the influence of ancient and renaissance poetics and rhetoric. In the course of the research, it is demonstrated that Scudéry builds the logic of the evolution of Western literature in the context of the idea of “progress”: the ancient and Renaissance Italian tradition appears as a stage that prepared the flowering of gallant poetry in France; such an understanding of the logic of the development of Western literature, leading to an emphasis on the role of women and focusing on light love poetry (Catullus, Petrarca) to the detriment of the philosophical tradition (Dante) is the result of the cultural policy of Superintendent Nicolas Fouquet, who was considered by a significant part of the French elites as a new “Patron of the Arts”.
The Formation of Meta-Language in French Literature in the 16th Century: from Poetical Treatises to “Libraries”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Staf Irina K.
Published: July 2022

“The article deals with the changes which the concept of literature underwent in 16th century France. The late medieval concept of poetry as fabula, allegorical fiction, is replaced in the middle of the century (by T. Sébillet, J. Peletier du Mans, Ronsard) by the Platonic idea of an innate divine gift. The idea of poetry-philosophy describing all possible phenomena of the universe henceforth serves as a prerequisite for the creation of works perfect from a formal point of view. The idea of the relation between poetry and rhetoric as well as the models to be imitated by the poet changes. Lists of canonical authors turn into a poetic topos as early as the late Middle Ages, but under the influence of Pleiades’ theories there is an increased interest in the figure of the “great author”, a symbol of national language and poetry, whose emergence means the achievement of the national culture of the Golden Age. Lists, however, are transformed at the end of the century into the first attempts to describe the totality of French literature (Lacroix du Maine and A. Duverdier’s “Libraries of France”) and its history (a work on ancient poets by C. Fauchet and Book VII of E. Pasquier’s “Inquiries into France”). In the Renaissance disputes and polemics becomes more visible the outlines of both the literary canon, which was embodied in the 17th century, and the historical approach to literature.
The Generic Nonlocal Fractal Calculus
Authors: Banchuin Rawid
Published: July 2022

The generic nonlocal fractal calculus scheme have been formulated in
this work. A unified derivative operator which employs an interpolated
characteristic between the generic nonlocal derivative in
Riemann–Liouville and Caputo senses has also been derived. For being
generic, an arbitrary kernel function has been adopted. The condition on
fractional order has been derived so that it is not related to the
γ-dimension of the fractal set. The fractal Laplace transforms of our
operators have been derived. A simple illustrative example and practical
ones have been presented. Unlike the previous power law kernel-based
nonlocal fractal calculus operators, ours are generic, consistent with
the local fractal derivative and employ higher degree of freedom. The
inverse relationships between our derivative and integral operators can
be achieved. The results obtained from the examples are significantly
different from such previous operator-based counterparts and
significantly depended on the kernel function. The unified operator
displays an interpolated characteristic as expected.
An extended car-following model under stochastic theory and its feedback control
Authors: Liu Z. H. , Kong Qinghu
Published: July 2022

In the actual traffic flow, vehicle driving is affected by many random
factors. Gaussian white noise is introduced into the optimization
velocity model to describe the random behavior, and a stochastic
optimization velocity model is proposed. In order to improve the
stability of traffic flow, the velocity difference of two successive
vehicles ahead is considered, and a velocity difference feedback control
model is established by taking the velocity difference between the
vehicle and the target two vehicle as the control signal. Then, the
stability conditions of stochastic optimization velocity model and
feedback control model are obtained by using the moment stability
theory. Last, Monte Carlo simulation is used to simulate the traffic.
The results show that considering the random factor will reduce the
stability of traffic flow, and the feedback control can effectively
improve the stability.
Boundedness in a predator-prey system with prey-taxis and nonlinear gradient-dependent sensitivity
Authors: Yingyuan Mi , Cui Song
Published: July 2022

In this paper, we extend the gradient-dependent nonlinear sensitivity
assumption of Keller-Segel-Navier-Stokes system [M. Winkler, Z. Angew.
Math. Phys. 2021] to predator-prey and Keller-Segel systems in two
dimensions. Under appropriate regularity assumption on the initial data,
the global boundedness of classical solution is obtained.
Does early olaparib administration improve prognosis in patients with HER2-negative metastatic breast cancer and BRCA1 and/or BRCA2 pathogenic variants?: Finding from four cases
Authors: Takuwa Haruko , Sasaki Shoko , Yamada Takahiro , Takeuchi Megumi
Published: July 2022

We herein describe our experience of four patients who had been
diagnosed as metastatic breast cancer with BRCA 1/2 pathogenic variants.
Prior anthracycline and/or taxane-based therapies needed before
administration of PARP inhibitors might be still controversial in terms
of patients benefit.
Multi-species crop mixtures increase insect biodiversity in an intercropping experiment
Authors: Brandmeier Jana , Reininghaus Hannah , Scherber Christoph
Published: July 2022

Recent biodiversity declines require action across sectors such as
agriculture. The situation is particularly acute for arthropods, a
species-rich taxon providing important ecosystem services. To counteract
negative consequences of agricultural intensification, creating a less
hostile agricultural “matrix” through growing crop mixtures can reduce
harm for arthropods without yield losses. While grassland biodiversity
experiments showed positive plant biodiversity effects on arthropods,
experiments manipulating crop diversity and management intensity to
study arthropods are lacking. Here, we experimentally manipulated crop
diversity (1-3 species, fallows), crop species (wheat, faba bean,
linseed, oilseed rape) and agrochemical input (high vs. low) and studied
responses of arthropod biodiversity. Increasing crop diversity increased
arthropod diversity and arthropod numbers. Mass-flowering crops
attracted more arthropods than legumes or cereals. Integrating
intercropping into agricultural systems could lead to a massive increase
in flower visits (up to 15 million visits/ha), indicating benefits of
intercropping for insect biodiversity and associated ecosystem services.
Unhealthy herds and the predator spreader: understanding when predation increases disease incidence and prevalence
Authors: Richards Robert , Elderd Bret , Duffy Meghan
Published: July 2022

Disease ecologists now recognize the limitation behind examining
host-parasite interactions in isolation: community members – especially
predators – dramatically affect host-parasite dynamics. Although the
initial paradigm was that predation should reduce disease in prey
populations (“healthy herds hypothesis”), researchers have realized
that predators sometimes increase disease in their prey. These
“predator-spreaders” are now recognized as critical to disease
dynamics, but empirical research on the topic remains fragmented. In a
narrow sense, a “predator-spreader” would be defined as a predator
that mechanically spreads parasites via feeding. However, predators
affect their prey and, subsequently, disease transmission in many other
ways such as altering prey population structure, behavior, and
physiology. We review the existing evidence for these mechanisms and
provide heuristics that incorporate features of the host, predator,
parasite, and environment to understand whether or not a predator is
likely to be a predator-spreader. We also provide guidance for targeted
study of each mechanism and quantifying the effects of predators on
parasitism in a way that yields more general insights into the factors
that promote predator-spreading. We aim to offer a better understanding
of this important and underappreciated interaction and a path towards
being able to predict how changes in predation will influence parasite
dynamics.
Tau protein misfolding and aggregation induced by abnormal N-glycosylation: Insights from Molecular dynamics simulation studies.
Authors: T Alen Mathew , TK Anurag Baidya , Das Bhanuranjan , Devi Bharti , Kumar Rajnish
Published: July 2022

Various post translational modifications like hyper phosphorylation,
O-GlycNAcylation, and acetylation have been attributed to induce the
abnormal folding in tau protein. Recent in vitro studies revealed
the possible involvement of N–glycosylation of tau protein in the
abnormal folding and tau aggregation. Hence in this study, we performed
microsecond long all atom molecular dynamics simulation to gain insights
into the effects of N-glycosylation on Asn-359residue which forms part
of the microtubule binding region. Trajectory analysis of the
stimulations coupled with essential dynamics and free energy landscape
analysis suggested that tau, in its N-glycosylated form tend to exist in
a largely folded conformation having high beta sheet propensity as
compared to unmodified tau which exists in a large extended form with
very less beta sheet propensity. Residue interaction network analysis of
the lowest energy conformations further revealed that Phe378 and Lys353
are the functionally important residues in the peptide which helped in
initiating the folding process and Phe378, Lys347&Lys370 helped
maintaining the stability of the protein in the folded state.
AUTOMATED MAMMAL LOCALIZATION AND IDENTIFICATION IN CAMERA TRAP IMAGES FOR THE NORTHEASTERN UNITED STATES
Authors: Barr Brannon , Underwood Harold , Mountrakis Giorgos , Quackenbush Lindi
Published: July 2022

1. Camera traps are popular for monitoring animal populations and
communities, primarily because they eliminate physical handling of
animals. However, image acquisition typically outpaces information
extraction. Most deep-learning based animal classifiers do not localize
animals, limiting their applicability. Existing networks that localize
animals have relatively high training data and hardware requirements. 2.
To reduce the hardware and training data requirements, we extended the
the Machine Learning for Wildlife Image Classification network (MLWIC2)
to a Faster R-CNN. MLWIC2 is currently the most accurate wildlife
classification network, and also the shallowest at 18 layers. We
compared our model’s performance at object localization, species
identification, and deployment speed to the performance of a generically
pre-trained 50-layer Faster R-CNN to determine a) relative importance of
task similarity in pre-training vs. backbone depth, b) whether
additionally finetuning the backbones during training is advantageous c)
whether the Faster R-CNN architecture benefits from incorporating the
feature pyramid network (FPN) and cascading pyramid network (CPN)
modules, and d) how backbone depth and the additional modules affect
deployment speeds. 3. We found that the deeper network provides a slight
advantage for classification accuracy, while the shallower network with
higher task similarity produces a slight advantage for object
localization. The additional modules provided dramatic gains for the 18
layer backbone for both classification and localization. On a NVIDIA
1080-ti gpu, the 18-layer backbone trains ~ 30% faster
than the 50-layer backbone. In deployment the 18-layer backbone is 2.5x
faster than the 50-layer backbone, and 9.4x faster than Megadetector.
These results show that backbone network task similarity, paired with
the FPN and CPN modules, can substitute for depth, which improves
deployment speeds. Our model is suitable for modest hardware and for
integration into more complex pipelines. These are important steps
towards the automation of data acquisition from camera trap images.
Computational Investigations of Indanedione and Indanone Derivatives in Drug Discovery: Indanone Derivatives Inhibits Cereblon, an E3 Ubiquitin Ligase Component
Authors: Nayek Upendra , Ahamed Syed Ibrahim Basheer , Halilunnisa Ummul , Unnikrishnan M. K. , Salam Abdul Ajees Abdul
Published: July 2022

Background: Cereblon, an extensively studied multifunctional
protein, is a Cullin 4-RING E3 ubiquitin ligase complex component and a
well-known target of thalidomide and its derivatives. Cereblon is
involved in the apoptosis of multiple myeloma cells. When ligands such
as lenalidomide bind to cereblon, it recognizes various neosubstrates
based on the ligand shape and properties. We have identified novel CRBN
inhibitors, namely DHFO and its analogs, with structural features that
are slightly different from thalidomide but stronger cereblon-binding
affinity. We selected indanedione and indanone derivatives from the
literature to understand and compare their cereblon-mediated substrate
recognition potential. Methods: Computational investigations of
possible cereblon inhibitors were investigated by molecular docking.
ADME/T and drug-likeness properties of the molecules were studied. A
molecular dynamics study was carried out for selected molecules, and the
molecular interactions were analyzed using PCA-based FEL methods. The
binding affinity was calculated using the MM-PBSA method.
Results: We conducted computational investigations on 68
indanedione and indanone derivatives binding with cereblon. Ten
molecules showed better CRBN binding affinity than thalidomide. We
studied the drug-likeness properties of the selected ten molecules, and
four of the most promising molecules (DHFO, THOH, DIMS, and DTIN) were
chosen for molecular dynamics studies. The MM/PBSA calculations showed
that the DHFO, already shown to be a 5-LOX/COX2 inhibitor, has the
highest binding affinity of -163.16 KJ/mol with cereblon.
Conclusion: The selected CRBN inhibitor DHFO has demonstrated
the highest binding affinity with cereblon protein compared to other
molecules. DHFO creates an interaction hotspot on the cereblon surface,
thereby serving as a novel alternative for thalidomide and its
derivatives. Ease of chemical synthesis, low toxicity, versatile
therapeutic options, and pleiotropism of DHPO analogues provide an
opportunity for exploring clinical alternatives with versatile
therapeutic potential for a new category of indanedione molecules as
novel modulators of E3 ubiquitin ligases.
Druggable sites identification in Streptococcus mutans VicRK system evaluated by catechols
Authors: Silveira Paulo Henrique Santana , Pita Samuel
Published: July 2022

Background: Dental caries is a global public health problem,
being the most common non-communicable disease. Streptococcus
mutans is the causative agent that develops cariogenic dental biofilms
in humans due to its ability to produce glycosyltransferases (Gtfs).
These Gtfs act in the exopolysaccharides synthesis (EPS) that form
biofilms. The gene expression encoding Gtfs is modulated by the VicRK
system, which are promising targets for dental biofilm inhibitor
developments. Objective: Predict druggable sites of
Streptococcus mutans VicK protein through molecular docking with
catechols. Methods: The prediction of VicK druggable sites was
performed by PockDrug and FTMap servers. From these data, a virtual
screening of 383 catechols was performed on AutoDock4.2. After docking
analysis some ligand efficiency indexes were calculated: LE, LELP, LLE
and BEI. Results: Three interaction sites (S1, S2 and S3) were
predicted for VicK, covering most important residues for its stability
and enzymatic activity. The catechols selected by the virtual screening
interacted with main amino acids for VicK auto kinase, and phosphatase
activity and showed optimal values ​​of ligand efficiency (LE, LELP, LLE
and BEI). Conclusion: After Virtual Screening calculations,
some catechols interacted favorably with essential residues for VicK
autokinase and phosphatase activities and presented optimal values ​​of
ligand efficiency (LE, LELP, LLE and BEI). Thus, catechols are promising
compounds for future in vitro tests aiming to develop new anticariogenic
and antimicrobial agents.
Sustainable Development Goals in The 21st Century: As Structual Examination of The Social Studies Course Curriculum in Turkey
Authors: YALÇIN Ali
Published: July 2022

The aim of this research is to examine according to the United Nations 2030 sustainable development goals, in the social studies course (4, 5, 6 and 7) curriculum; specific objectives, achievements, skills and values structurally. This study was designed according to qualitative research patterns. The main data sources of the research consist of the 2018 social studies course curriculum and the United Nations 2030 sustainable development goals booklet. The data collected by the document method were analyzed according to the descriptive analysis method. In this context, special goals, achievements, skills and values that are structurally compatible with the United Nations 2030 sustainable development goals are indicated in the tables and then interpreted in a comparative way. According to the results of this research, it can be said that the 2018 social studies course curriculum is structurally compatible with the specific objectives, achievements, skills and values of the United Nations 2030 sustainable development goals. It has been determined that among the sustainable development goals, accessible energy resources target, social studies course curriculum, special goals, achievements, skills and values do not structurally overlap with goals and acquisitions. For this, goals and achievements for accessible energy resources can be added to the social studies curriculum. Sustainable development goals offer solutions to the events taking place in the world and set appropriate targets. For this reason, the social studies course curriculum can benefit both structurally and content with the sustainable development goals.
Representation and its limits: 2020 protests against curfew
Authors: Simendic Marko
Published: July 2022

The paper deals with the ways in which representatives (both Serbian government officials and opposition politicians) described the protest against the curfew in 2020 and its participants. From the perspective of the ?constructivist? turn in scholarship on representation, the paper branches into two main lines of enquiry: 1) what did the representatives say about the protests and the protesters; 2) how did they (re)define the represented and their relationship towards them. The representatives recontextualise the protests: translate the incidents and the lack of well-articulated demands into a narrative about violent demonstrations and unrepresentable protesters. Consequently, they ignore and delegitimise possible systemic reasons for discontent, desubjectivise a significant number of protesters and, in turn, exclude them from the process of representation.
Media pluralism in competitive authoritarian regimes - a comparative study: Serbia and Hungary
Authors: Milutinovic Irina
Published: July 2022

This paper explores media pluralism in two European former communist countries, which have regressed to electoral authoritarianism in recent years, after a period of democratic transition and partial consolidation - the Republic of Hungary and the Republic of Serbia. The aim of the study is to describe similarities and differences in the media policies of these countries regarding media pluralism, and to explain social and political context that generates the growing risk for media pluralism. Descriptive comparative methods were used, based on the original set of data quantified within the annual national MPM reports. The reference time frame covers 2020 and 2017. The risk assessment indicators for media pluralism were compared in three areas: normative protection, political independence and media market plurality. The research finds that competitive authoritarian regimes? methods for free, independent and pluralistic media suppression have been intensively used in both countries regardless of membership status in the European Union.
Adatfúziós távérzékelési eljárások kis méretű pilóta nélküli légi járművek alkalmazásával
Authors: Molnár András
Published: July 2022

Azonos időben történő, látszólag független adatok rögzítése során létrehozhatók idő szerint összekapcsolt adatstruktúrák, amelyeket „n” dimenziós adathalmaznak is tekinthetjük. A halmaz egyes elemei között ismert a kapcsolat, így lehetőség nyílik tetszőleges adatcsoportok egymás függvényében történő kiértékelésére, elemzésére. A kis méretű pilóta nélküli légi járművekkel vagy – angol terminológia szerint SUAV-kkel (Small Unmanned Air Vehicle) – végzett távérzékelés során gyűjtött mérési adatok ilyen értelmű tárolása és feldolgozása különösen előnyös, mivel lehetőséget biztosít komplex összefüggések feltárására vagy a hagyományos mérési és feldolgozási eljárásokhoz képest érzékenyebb, szelektívebb változások kimutatására. A módszer jól alkalmazható hagyományos, egydimenziós adatsorok összekapcsolására, de ugyanilyen eredményes akár több detektorral készített, egymástól független, de egymáshoz kapcsolt képi adatok esetén is. Természetesen kombinált adatstruktúrák esetén is jó eredmények érhetők el például képi információkhoz kapcsolt egydimenziós adatokkal. Hasonlóan érdemi információk nyerhetők ki rendkívül zajos egydimenziós mérési eredményekhez kapcsolt kétdimenziós helyadatok komplex elemzése során.
Konténerek katonai alkalmazásának új lehetőségei I. rész
Authors: Ott István Dániel
Published: July 2022

Az 1930-as években az USA-ban szabadalmaztatott szállítási egység – közismert nevén a konténer – megteremtette az egyszerű és gyors egységrakomány-képzést. A zárt konténerek lehetővé teszik, hogy bennük mobil lakóteret vagy irodát alakítsanak ki. Ilyen konténerek gyártásával, fejlesztésével és forgalmazásával foglalkozik a magyar Continest Technologies Zrt. is. A cégnél fejlesztés és tesztelés alatt állnak ballisztikai védelemmel ellátott, összecsukható, napelemmel vagy hibrid energiaforrással szerelt egységek is, amelyeket a Magyar Honvédség Modernizációs Intézetével közösen fejlesztenek a Honvédelmi és Haderőfejlesztési Program (HHP) keretében.
A terepi járműmozgást befolyásoló tényezők II. rész
Authors: Kiss Péter , Kiss Botond Levente , Böröczky András
Published: July 2022

A terepen mozgó járművek jellemzően kerekes futóművel, lánctalpas járószerkezettel vagy ezek kombinációjával rendelkeznek. A terepi járműmozgást számos tényező befolyásolja, amelyeket három csoportban foglalhatunk össze: járműparaméterek, terep- és talajparaméterek, valamint a jármű mozgását befolyásoló emberi tényezők. A tanulmánysorozat első része a terep- és talajjellemzőkkel foglalkozik, valamint bemutatja a terep és a talaj járműmozgást befolyásoló hatásait, a jármű és a terep kapcsolatát.
Új képességet kapott a Magyar Honvédség
Authors: Dóczi István , Szilák Zsolt
Published: July 2022

A szerzők közleményükben beszámolnak a Honvédelmi és Haderőfejlesztési Program keretében megvalósított tábori híradó informatikai alhálózatkészletek fejlesztéséről és konfigurációiról. A katonai vezetésirányítási rendszerek rövid áttekintése segít felmérni az új képesség jelentőségét és megkönnyíti az informatikai készletet elhelyezését a korszerű eszközök rendszerében.
Egy elfelejtett magyar ejtőernyő, a ZF–2
Authors: Kovács Csaba
Published: July 2022

Az 1990-es éveket követő időszakban mind a sport-, mind a katonai ejtőernyőzés rendszerében jellemző volt a hagyományoskörkupolás alapkiképzési módszer alkalmazása. A polgári életben több évtizeden keresztül alkalmazott RS–4/4 típus a 2000-es évek elején „eltűnt” a sportejtőernyőzésből. Körkupolás utód nem érkezett, közben a légcellás technika folyamatos térnyerésével egyre inkább a légcellás alapképzések terjedtek el. A Magyar Honvédségben (a továbbiakban: MH) a bővített ejtőernyős alapkiképzés meghatározó eszköze több évtizeden keresztül szintén az RS–4/4 típusú ejtőernyő volt, egészen 2018 nyaráig, amikor a típus LA változatát – a naptári üzemidő lejártával – végképp kivonták a rendszerből. Az MH körkupolás ejtőernyője azóta az amerikai MC–6 típus, amely 2014 óta áll alkalmazásban.
First record of Trocheta subviridis Dutrochet, 1817 (Arhynchobdellida, Erpobdellidae) from the north-eastern Iberian Peninsula (Navarra, Spain)
Authors: Cancellario Tommaso , Miranda Rafael , Baquero Enrique , Grosser Clemens
Published: July 2022

We reported the first record of the rare species Trocheta subviridis Dutrochet, 1817 (Arhynchobdellida, Erpobdellidae) from north-eastern Spain (Suspiro stream at Señorio de Bértiz Natural Park, Navarra, Spain). The species was previously recorded in Spain by Cordero del Campillo (1980) and García Más and Jiménez (1981). However, the latter authors admitted (Garcia Más & Jiménez, 1984) that both citations could be considered erroneous due to a misinterpretation by Cordero del Campillo of Blanchard (1893) (Jueg, 2008). Thus, considering the limited and uncertain information about T. subviridis in Spain, we can argue that our specimen is the first valid record reported for the species in the Iberian Peninsula.
Posterior Segment Pathologies in Leprosy Patients with Visual Impairment: A Case Series
Authors: Adriono Gitalisa Andayani , Nadhira Andi Marsa , Kurnia King Hans , Irawati Yunia
Published: July 2022

Leprosy is an important infectious disease, which is still prevalent in developing countries including  Indonesia. This disease may affect the skin, extremities, peripheral nerves, and the eyes, causing disabilities of the patient. Leprosy is known to cause various ocular disorders, however, posterior segment abnormalities which involve the retina, choroid dan vitreous, have rarely been reported. Therefore, we present a case series of patients with posterior segment pathologies in visually impaired leprosy patients. These patients were identified during a community-based screening program on 99 leprosy patients, held in July 2019 in Alverno Hospital, Singkawang West Kalimantan. Patient comprised of inpatients and former patients who lived within the city and nearby cities who were invited for the program. All patients underwent comprehensive ophthalmology examination, performed by general ophthalmologists. Visual impairment was found in 15 patients, and their pupils were dilated, followed with posterior segment examination with indirect ophthalmoscopy and fundus photograph, using a handheld fundus camera, done by a vitreoretina specialist. Out of all patients screened, we did not find any leprosy-related posterior segment abnormalities. However, posterior segment pathologies were found in six patients, including peripapillary atrophy, myopic crescent, drusen and chorioretinal atrophy. One patient showed extensive chorioretinal atrophy with pigment clumping, which may be caused by leprosy- related chronic inflammatory process.
Nilai Pengetahuan Pemanfaatan Air Sungai, Faktor Sosiodemografi, dan Sosioekonomi Warga Daerah Aliran Sungai Citarum
Authors: Werdhani Retno Asti , Yuliani Dini , Herliana Monika , Anugrapaksi Eghar
Published: July 2022

Sungai Citarum merupakan sungai tercemar di dunia dan digunakan oleh masyarakat di daerah aliran sungai (DAS). Penelitian ini bertujuan mengetahui hubungan faktor sosiodemografi dan sosioekonomi, denganpengetahuan pemanfaatan air Sungai Citarum pada warga di DAS Citarum, Jawa Barat. Studi potong lintang inimenggunakan data sekunder penelitian Indonesian One Health University Network (INDOHUN) pada tahun 2018.Profil sosiodemografi, sosioekonomi, dan pengetahuan pemanfaatan air diperoleh melalui kuesioner wawancaraterpimpin. Sebanyak 155 orang berusia produktif yang bertempat tinggal di Kelurahan Andir dan Kelurahan/DesaGajahmekar, Kabupaten Bandung, Jawa Barat, terpilih secara acak dengan teknik clustered random sampling.Mayoritas responden merupakan masyarakat berusia 18 - 45 tahun (61,3%), perempuan (78,1%), pendidikan rendah(74,2%), ibu rumah tangga (64,5%), dan memiliki status ekonomi rendah (81,6%). Median nilai pengetahuan 54,55(0–100). Nilai pengetahuan pada kelompok pendidikan rendah dan pendapatan di bawah UMR lebih kecil secarabermakna dibandingkan kelompok pendidikan sedang-tinggi dan pendapatan di atas UMR (masing-masing p=0,027dan p <0,001). Pada kelompok usia dan jenis kelamin tidak berbeda bermakna dengan pengetahuan pemanfaatanair (masing-masing p=0,414 dan p=0,315). Terdapat perbedaan skor pengetahuan pemanfaatan air Sungai Citarumsecara bermakna antar kelompok pendapatan dan tingkat pendidikan masyarakat di DAS Citarum.
Necrotizing Fasciitis in a Leprosy Patient
Authors: Nie Nie , Natasha Augustine , Pribadi Sweety , Saharman Yulia R. , Rizal Chairunissa T. , Karuniawati Anis , Sudarmono Pratiwi
Published: July 2022

Leprosy is an infection caused by Mycobacterium leprae. Disability after the infection is common  and necrotizing fasciitis could deteriorate the patient current condition. We present the case of necrotizing fasciitis of the right limb inpatient with tarsal disintegration and plantar ulcer due to previous leprosy infection.  The microbiology culture was inadequate in the early stage of management, which delayed the definitive  antibiotic for patient and the progressive necrotic infections were uncontrolled. Amputation was done to save the patient’s life and the latter microbiology culture was able to determine the definitive antibiotic therapy. This report highlights the needs of disability management and infection control for leprosy patient after the treatment is completed.
Observational Study of Paclitaxel-Carboplatin versus Pemetrexed-Carboplatin for Advanced Pulmonary Adenocarcinoma at Single-Centre in Indonesia
Authors: Rianyta Rianyta , Louisa Melva , Syahruddin Elisna , Soetikno Vivian
Published: July 2022

Platinum-based chemotherapy regimens with two types of drugs, such as paclitaxel-carboplatin and pemetrexedcarboplatin, are first-line therapy for pulmonary adenocarcinoma patients with negative epidermal growth factor receptor (EGFR) mutation. This study aimed to determine the efficacy, toxicity, and cost profile of paclitaxel-carboplatin compared to pemetrexed-carboplatin. This is a cross-sectional study. Pulmonary adenocarcinoma negative EGFR mutation naïve patients treated with paclitaxel-carboplatin or pemetrexed-carboplatin were included. Effectiveness was assessed based on the overall response rate (ORR) according to the response evaluation criteria in solid tumours (RECIST). A pharmacoeconomic analysis is performed based on clinical outcomes consisting of effectiveness and direct medical costs. Medical records from 21 patients with paclitaxel-carboplatin and 21 patients with pemetrexedcarboplatin were successfully evaluated. The effectiveness of the two chemotherapy regimens was not significantly different (OR, 1.25; 95% confidence interval, 0.34 to 4.64; p = 0.739). Frequent haematological toxicities experienced in the two groups were grade 1-2 anaemia, neutropenia, leukopenia. Grade 3 anaemia, leukopenia, and neutropenia were more common in the paclitaxel-carboplatin group. The two groups’ nonhematological toxicities were nausea vomitus and hair loss, with peripheral neuropathy more experienced by the paclitaxel-carboplatin group. Costminimization analysis reveals that the average cost per patient with pulmonary adenocarcinoma negative EGFR mutation with paclitaxel-carboplatin regimen was cheaper IDR 10,986,257.55 or 50.25%, compared to pemetrexedcarboplatin. In conclusion, there was no significant difference in the effectiveness of the two regimens. The most common adverse effects in both regimens were haematological toxicities. The average cost per patient with a paclitaxel-carboplatin regimen was cheaper compared to pemetrexed-carboplatin.