bluuebunny/crossref_metadata_2025 huggingface dataset:
Terms of Citizens 'Rights Restriction when Applying Measures of Criminal Procedure Forcing
Authors: Askat E.A. , Zhaksybayev B.E. , Sakharbay A. , Nurbeko A.M. , Khanov T.A.
Published: June 2023

The article considers the nature and purpose of measures of criminal procedure coercion. The authors highlighted the grounds for restricting constitutional rights and freedoms when using coercive means. The author’s definition of measures of criminal procedural coercion is formulated, which means: the preventive action applied by the authorities conducting the criminal process in the criminal case aimed at achieving the objectives of the pre-trial investigation and trial or ensuring proper conduct of the participants in the criminal process specified in the law, if any conditions and circumstances that necessitate the use of such an impact. The issues of legality and localization criteria of personal property and non-property subjective interests of citizens are raised. The analysis of the main classifications of measures of procedural coercion is carried out, and the author's approach to the classification of measures of procedural coercion is proposed, based on the conditions and the real need to limit the rights and legitimate interests of the person. Article materials can be of practical value for employees of investigative units conducting pre-trial investigations and encountering problems with the application of procedural coercive measures.
Responsibility for Illegal Use of Trademarks: International and Interstate Aspects
Authors: Selivanovskaya Julia Igorevna , Talan Mariya Vyacheslavovna , Sboeva Irina Mihailovna
Published: June 2023

A trademark is a widespread means of product individualization, which allows you to draw attention to the product, its manufacturer, or the seller. In fact, Goods, works, service individualization tools in the Russian Federation are the outcome of mental activity. Trademark registration makes it possible to form an easily recognizable brand and use it in order to sell it successfully among similar products. A manufacturer, promoting his product on the market, spends money on advertising, and increases the attractiveness of his products. Unscrupulous entrepreneurs are very tempted to produce goods using a famous brand, without corresponding costs, and without keeping a high quality of his goods. This article discusses the international and domestic aspects of accountability for the illegal usage of a trademark and provides recommendations for R.F. criminal law improvement. Moreover, Several investigation methods are utilized in the survey, including statistical, systematic and structural, historical and legal, formal and logical, specific sociological, as well as comparative law.
Abuse of Rights in Labor Relations: Concepts, Motives, Beneficial and Adverse Consequences
Authors: Melnyk Kostiantyn , Tsesarsky Felix , Zaitsev Oleksii , Yatsenko Tamara , Zaitsev Oleksii
Published: June 2023

The article contains the studied issues of abuse of rights in labor relations: the concept of "abuse of rights in labor relations" has been defined, its motives, and beneficial and adverse consequences have been analyzed. The authors emphasize that "abuse of rights" as a legal fact arisen in specific life circumstances may have both beneficial and adverse social content. All this resulted from the fact that legislative practice does not keep up with real conditions of changing labor relations affected by dynamic circumstances of modern social and economic development of society. To develop new approaches to definition of the fundamental principles of labor law to ensure the rights of all participants in labor relations on the principles of equality before the law seems now to be very important. The solution to this problem is in formulation of a universal definition of the concept "abuse of rights in labor relations" like actions or inactions in the legal environment of labor law, based on antisocial motives of these actions (inactions), which do not coincide with motives officially indicated, resulting in adverse social consequences such as discrimination, oppression of labor rights of citizens and stateless persons, violation of the requirements for safe and healthy working conditions. In turn, according to the authors, actions or inactions beyond labor law, but based on positive social motives, resulting in beneficial social consequences such as labor rights of citizens and stateless persons for safe and healthy working conditions, production safety, environmental society, etc., shall not be considered as "abuse of rights" (but as "beneficial abuse of rights").
Modern Trends in the Tax Audit Market
Authors: Udovikova Alla A. , Marchenkova Irina N.
Published: June 2023

As Russia transited to market relations, it formed an independent audit service, which emergence prerequisites were the mutual interest of state bodies, the managing administration of the enterprise and its owners in reliable financial and accounting information. The audit has become an integral part of economic relations and has been recognized by most countries of the world. This was facilitated by the need for means of implementing and protecting property interests, enhancing economic benefits and minimizing entrepreneurial risk. The main aim of the study is to investigate the market economy and tax audit market, which determine the development of new activities for the implementation and regulation of economic relations, predetermined the creation of organizations that regulate the processes of accounting and tax accounting. To accomplish that aim, the methods of deduction, induction, systematization and generalization of theoretical and practical materials are utilized. Based on the outcomes, a new type of activity at that time was an audit, which provided protection of the legal property interests of business entities by means of independent financial control, confirmation of the authenticity of balance sheets and reports on the results of economic activities, and the provision of related services.
The Assistance Model of the Baitul Mal in Promoting The Community of Home Industry
Authors: Sabirin  , Masriza  , Zainuddin Muslim , Zulyadi Teuku , Husna Nurul , Drani Syazwani
Published: June 2023

Baitul Mal as an institution for collecting and distributing zakat, infaq, and shadakah among Muslims, has not yet developed community economic programs, especially home industries. Although the community economic development program has been implemented, the assistance model provided so far has not been able to provide increased income for the community. This article responds to the view that Baitul Mal in carrying out its programs is only consumptive in nature and has not been able to develop productive programs related to the community's economy by providing venture capital for home industry players. This qualitative research in finding a model of Baitul Mal assistance was done through observation, interviews, and documentation. The data obtained is used to strengthen the research objectives in supporting the assistance model for the assistance of Baitul Mal Aceh. This study found that the Baitul Mal Aceh program was more dominant in the field of consumptive zakat, while the assistance model of Baitul Mal assistance in the form of productive zakat had not been able to provide maximum results for the economic development of the community, especially in the home industry sector. So in the future, there needs to be an improvement, as an initial solution in introducing the Baitul Mal Aceh assistance model to the community.
Economic and Legal Mechanisms of Interstate Support for Agricultural Producers
Authors: Bazenov Airat B. , Begzhan Aizat M. , Zhunissov Zhassulan S. , Tazhikov Abzal K. , Amandossuly Bagdat
Published: June 2023

The transitional stage in the agrarian economy requires an optimal combination of state protection and market levers. At present, the state regulatory influence on the development of agriculture remains, on the one hand, quite significant, and on the other, insufficiently effective. There is no systemic integrity in the practice of state regulation of the agricultural sector. The relevance of the study is that in transition economies, agrarian protectionism was initially caused by somewhat different circumstances, and the protectionist policy was formed in fundamentally different conditions. The authors demonstrate that protectionism in industrial-type transition economies inherited a huge mechanism of state support for the agro-industrial complex in the depths of a centrally planned economy. Everywhere this support constituted a heavy burden of national finances, and one of the primary tasks of reforms in transition economies, including agrarian reforms, was precisely the release from this burden. It causes sharp liberalization of agrarian policy in almost all countries. The method of analysis was used to investigate the main directions, methods, and mechanisms of state regulation of the economy in different countries; the priority areas of state regulation of prices in the agro-industrial complex industry were highlighted. The practical significance of the study is that macroeconomic reforms in countries with an industrial type of development led to a rapid deterioration in the financial situation of the agricultural sector.
How Self Control and Situational Pressure Influence the Tendency to Receive Gratification: An Experimental Study
Authors: Ariyanto Dodik , Maulana Firdaus Gilang , Mediatrix Ratna Sari Maria , Aryista Dewi Ayu , Gilang Jhuniantara I Made
Published: June 2023

This study aimed to produce empirical evidence on tendency differences to accept gratuities between individuals with a high level of self-control and a low level of self-control, the conditions are the presence or absence of situational pressure. The method used is an experiment with a 2x2 factorial design. A total of 136 officers and staff in the Directorate General of State Bali region become research participants. The data were processed with statistical parametric, two-way ANOVA. The results showed that individuals with high levels of self-control have a lower tendency to accept gratuities than participants with lower levels of self-control. However, this study did not obtain empirical evidence indicating situational pressures experienced by the individual can affect the tendency to accept gratuities. Interaction hypothesis testing showed that the interaction between the individual levels of self-control and situational pressures experienced affects the tendency to accept gratuities.
The Response of South Africa’s Policy Landscape to Global and Local Trends - The Case of a Rural-Based University
Authors: Pillay Pravina , Pillay Thayabaran
Published: June 2023

Globalisation is a highly contested term and has become a site for tension. Whilst globalisation in the context of Higher Education must be lauded for giving students and scholars access to work on a global platform, it has also reinforced inequalities that are already prevalent and has even created new ones. The negative impact of globalisation is evident most explicitly in developing countries such as South Africa and in smaller institutions of Higher Learning such as the University of Zululand. To compound the already precarious situation, one finds that in addition to accommodating elements of globalisation, institutions of Higher Learning have to also accommodate local trends such as the Africanisation of Education. Whilst globalisation has swept across the world and has impacted almost every sphere of life, the foci of this paper is on how policies in Higher Education, with special reference to the University of Zululand, have responded to global trends and local needs. This is a qualitative study. The methodology used is document analysis. This study interrogates the Language and Research policies of the University of Zululand to illuminate on how the aforementioned institution responds to global and local needs. The main finding of the study is that institutions of Higher Learning, in crafting their policy documents, are incorporating globalisation and are finding innovative ways of embracing local trends at the same time.
Value Assessment of Oncology Pharmacist Interventions
Authors: P. Patel, PharmD, CPP Mallika , Y. Barbour, PharmD, BCOP, CPP, FHOPA Sally , T. Moorman, PharmD, BCOP, CPP Meredith
Published: June 2023

A review of the published literature confirms the challenge in quantifying the value of oncology pharmacists. This editorial expands on a 2020 study by Meleis and colleagues published in the Journal of the Advanced Practitioner in Oncology and seeks to correlate pharmacist interventions to cost-saving and cost-avoidance measures to show the value of ambulatory oncology clinical pharmacists in patient care. A total of 4,686 interventions were reviewed. The 6-month intervention data demonstrate an annualized value of approximately $1.1 million dollars from nine ambulatory oncology clinical pharmacists showcasing the essential role of the clinical pharmacist in ambulatory oncology settings.
Heart Failure in a Patient With Metastatic Well-Differentiated Neuroendocrine Tumor
Authors: Henderson, ANP-BC, AOCNP Amy , Al Mutar, MD Salwan
Published: June 2023

Patients with neuroendocrine malignancy with liver metastases are at risk for carcinoid heart disease which, if left unchecked, can lead to heart failure. This case study demonstrates a clinical situation in which an advanced practitioner performed a thorough workup consisting of lab work and imaging studies, including echocardiogram, cardiac MRI, and dotatate PET/CT, as well as outside record review and comprehensive physical exam. Early detection, intervention, and control of disease are paramount to prevent potentially life-limiting carcinoid heart disease.
Los hábitos saludables y la salud mental de universitarios en carreras no relacionadas con la salud
Authors: García-Pérez Laura , Zamorano Silvia , Rojas-Cepero Iago , Miras-Moreno Sergio
Published: June 2023

The university population is one of the most likely to adopt risky health behaviors. For this reason, a cross-sectional study was carried out with 184 university students in Granada. The aim was to determine the level of adherence to the Mediterranean diet, the level of physical activity, and the mental health of the quality of Life. Validated questionnaires were used: IPAQ-SF, KIDMED and SF-36. The main results were that most university students did not adhere to a quality diet, but did meet the minimum recommended physical activity. Additionally, university students with higher physical activity scores had a better diet and a better level of mental health. Therefore, it is a need to educate and train students in healthy habits. To this end, university programs should be created to encourage the student population to be physically active and take greater care of their diet.

La población universitaria es una de las más propensas en adoptar conductas arriesgadas para la salud. Por ello se planteó una investigación transversal con 184 estudiantes universitarios de Granada donde se quiso conocer el nivel de adherencia a la dieta Mediterránea, el nivel de práctica de actividad física y la salud mental de la Calidad de Vida Relacionada con la Salud. Se emplearon cuestionarios validados: IPAQ-SF, KIDMED y SF-36. Los principales resultados fueron que la mayoría de los universitarios no tenían adherida una dieta de calidad, pero sí cumplían con las recomendaciones mínimas de práctica de actividad física. Además, los universitarios con mayores puntuaciones en la práctica de actividad física, presentaron una mejor alimentación y mejor nivel de salud mental. Por lo tanto, se contempla la necesidad formar y capacitar al alumnado en hábitos saludables. Para ello, desde el ámbito universitario, se deberían crear programas que animaran a la población estudiantil a mantenerse físicamente activos y cuidar en mayor medida su alimentación.
Ira y actividad física. Un estudio en estudiantes universitarios
Authors: Galdón-López S. , Fernández-García-Valdecasas B. , Álvarez-Ferrándiz D.
Published: June 2023

Physical activity is of vital importance in these times where uncertainty and desperation abound. It has become the solution given that knowing its benefits and being constant the proposed goals can be achieved. For these reasons, the following objectives were set: to analyse the level of physical activity and anger and to establish the possible relationships between general, academic, psychosocial and physical-sports variables in university students, with a total sample of 497 university students aged between 18 and 51 years. Various instruments have been used to achieve the objectives such as an ad-hoc questionnaire for the socio-demographic variables. On the other hand, the attitude scale towards physical activity and the Aggressiveness Questionnaire, for the psychosocial variables. The results show how doing physical activity on a daily basis and having a good attitude towards it reduces aggressive behaviour in university students and, thus reduces their irascibility.

La actividad física es de vital importancia en estos tiempos donde abunda la incertidumbre y desesperación de las personas. Esta se ha convertido en la solución dado que conociendo sus beneficios y siendo constante se pueden lograr las metas propuestas. Por estas razones, se plantean los siguientes objetivos: analizar el nivel de actividad física e ira y establecer las posibles relaciones entre las variables generales, académicas, psicosociales y físico-deportivas en estudiantes universitarios, con una muestra total de 497 estudiantes universitarios de edades comprendidas entre los 18 y 25 años y una edad media de 21,50 años (DT=6,24). Se han utilizado diversos instrumentos para la consecución de los objetivos como un cuestionario de tipo ad-hoc, para las variables sociodemográficas. Por otra parte, la escala de actitud hacia la actividad física y el cuestionario de agresividad, para las variables psicosociales. Los resultados muestran cómo realizar actividad física de manera diaria y tener una buena actitud hacia esta reduce las conductas agresivas en los estudiantes universitarios y, por ende, ven reducida su irascibilidad.
Impacto de las nuevas tecnologías en los niveles de actividad física y sedentarismo en el alumnado de Educación Secundaria Obligatoria: Diagnóstico y plan de acción
Authors: Pérez-Díaz Juan-José , Salas-Montoro José-Antonio , Rodríguez-Gallego Laura , Mateo-March Manuel
Published: June 2023

Currently, new technologies are integrated into society and are an important and significant part of the lives of the youngest. These new technologies are sometimes related to sedentary behaviour that has led to reduced levels of physical activity in children, a factor that is directly related to an increase in childhood obesity. It is intended to find a new approach in which new technologies do not imply a cessation of physical activity but increase it and help improve the motivation of students towards it. These are considered as an opportunity to include physical activity in the lives of students, so it is about taking advantage of the important part that these suppose in their day to day life and the levels of attention that they provoke to integrate them into the subject of Physical Education.

Actualmente las nuevas tecnologías están integradas en la sociedad y son una parte importante y significativa en la vida de los más jóvenes. Estas nuevas tecnologías en algunas ocasiones están relacionadas con un comportamiento sedentario que ha desembocado en la reducción de los niveles de actividad física de los niños, factor que está directamente relacionado con un incremento de la obesidad infantil. Se pretende buscar un nuevo enfoque en el que las nuevas tecnologías no supongan un cese de la actividad física, sino que la incrementen y ayuden a mejorar la motivación del alumnado hacia esta. Éstas se consideran como una oportunidad para incluir la actividad física en la vida de los alumnos, por lo que se trata de aprovechar la parte tan importante que estas suponen en su día a día y los niveles de atención que les suscitan para integrarlos en la asignatura de Educación Física.
Effect of repair and thermal cycling on the flexural strength of denture base materials fabricated from different methods
Authors: TUĞUT Faik , KOYU Tuğçe
Published: June 2023

Objective: The aim of this study was to evaluate the flexural strength of the denture base materials produced by different methods after repair and was to evaluate effect of thermal aging.

Materials and Methods: A total of 120 specimens were fabricated by conventional, CAD/CAM milled, and 3D-printed denture base materials for this in vitro study. Specimens were divided into four groups; non-repaired groups (N), repaired groups (R), non-repaired-aged groups (N-aged), and repaired-aged (R-aged) groups. In N groups, specimens were stored in the water bath for 24 h before the flexural strength test. In N-aged groups, samples were subjected to thermal aging for 5000 cycles, then tested. For repaired R groups, samples were repaired with auto-polymerized acrylic resin and storage in the water bath for 24 h then tested. For the R-aged groups, samples were repaired with auto-polymerized acrylic resin, aged for 5000 cycles, then tested. Specimens were performed a three-point loading test using a universal testing machine. Data were analyzed using Wilcoxon and Kruskal-Wallis tests.

Results: When the groups were compared with each other, the difference between all groups was found to be statistically significant (p
Reporting Mobile Device-Mediated Text to Manage Action and Agency in Co-Present Conversation
Authors: Robles Jessica S. , DiDomenico Stephen M. , Raclaw Joshua , Joyce Jack B.
Published: June 2023

The paper considers the role of agency in human interaction with mobile devices. We use multimodal conversation analysis to trace how mobile screen content is reproduced as locally relevant for updating information for co-present interlocutors. While informing-centered actions supported by mobile devices may sometimes have the character of an agentic intrusion into the local interaction, we show that the organization of device-accessed information and its meaningfulness is nonetheless positioned in relation to how device-supported updates are animated into social action by human participants. This research contributes to understanding how device-related content is sequentially incorporated into face-to-face interaction.
"Carbonífero de Puertollano" Natural Monument (Puertollano basin, Spain): a window for the knowledge of Early Vertebrates
Authors: Soler-Gijón Rodrigo , Díez Ruiz Antonio
Published: June 2023

Coal mining at the Puertollano Carboniferous basin has led to the discovery and study of numerous fossiliferous layers, rich in chondrichthyan, actinopterigyan and tetrapod remains. The end of the mining operations and closure of the mines could also represent complete cease of paleontological prospections and field work at the Puertollano basin. Fortunately, three quarries, called María Isabel, La Extranjera and La Tejera, have been declared a Natural Monument. Consequently, they are protected by law and reserved for geological and palaeontological scientific research. In this paper, we describe the geology of the Natural Monument and its vertebrate fossil record. The outcrops of the three quarries show the most superficial part of the stratigraphic series so that they inform about the latest stages of the sedimentological and palaeogeographical evolution of the Puertollano basin. The actual coal basin appears to represent a remnant of a much larger basin which opened eastward to the Paleo-Tethys. The diverse chondrichthyan assemblage (acanthodians, xenacanths and euselachians) and euryhaline actinopterygians, and the presence of tidal rhythmites, indicate an estuarine-deltaic environment. Future sedimentological and paleontological studies at the Natural Monument will inform about the degree of marine influence in the basin and the changes of the vertebrate communities.
Soviet Unofficial Art and the Chinese Juelan Art Society in the twentieth Century: Compositional and genre searches and creative parallels
Authors: Fang Jinxu
Published: June 2023

The article is devoted to the exhibition and creative activities of representatives of the Juelan Society and figures of Soviet unofficial art – a comparative analysis allows us to see common points regarding the choice of artistic means and techniques, themes and motives, the fate of creative associations. The purpose of the article is to determine the similarities and differences of the process of the origin of unofficial art in China and Soviet Russia. The author's field of attention includes identifying similarities in the choice of genre, composition, artistic means, as well as the semantic content of the images revealed in the works of artists. It is important for the disclosure of the topic to determine the features and common features in the organization of creative activity and communication between members of artistic associations. The study concluded that Chinese and Soviet figures of unofficial art rallied around small associations, "circles", clubs, societies, offering an alternative to the official and, from their point of view, regressive art view of independent creativity. The artists of the Juelan Society sought to instill a modernist vision in Chinese culture, and Soviet conformists decades later developed their own understanding of contemporary art. Their attempts had a strong influence on the work of Chinese painters of subsequent generations and became a phenomenon in the art of their countries, still have an impact on its development. Their ideas and creative findings are the sources of the processes that take place in the artistic worlds that cooperate in the field of culture of Russia and China.
Three-dimensional imaging of vascular development in the mouse epididymis
Authors: Damon-Soubeyrand Christelle , Bongiovanni Antonino , Chorfa Areski , Goubely Chantal , Pirot Nelly , Pardanaud Luc , Piboin-Fragner Laurence , Vachias Caroline , Bravard Stephanie , Guiton Rachel , Thomas Jean-Leon , Saez Fabrice , Kocer Ayhan , Tardivel Meryem , Drevet Joël R , Henry-Berger Joelle
Published: June 2023

Long considered an accessory tubule of the male reproductive system, the epididymis is proving to be a key determinant of male fertility. In addition to its secretory role in ensuring functional maturation and survival of spermatozoa, the epididymis has a complex immune function. Indeed, it must manage both peripheral tolerance to sperm antigens foreign to the immune system and the protection of spermatozoa as well as the organ itself against pathogens ascending the epididymal tubule. Although our knowledge of the immunobiology of this organ is beginning to accumulate at the molecular and cellular levels, the organization of blood and lymphatic networks of this tissue, important players in the immune response, remains largely unknown. In the present report, we have taken advantage of a VEGFR3:YFP transgenic mouse model. Using high-resolution three-dimensional (3D) imaging and organ clearing coupled with multiplex immunodetections of lymphatic (LYVE1, PDPN, PROX1) and/or blood (PLVAP/Meca32) markers, we provide a simultaneous deep 3D view of the lymphatic and blood epididymal vasculature in the mature adult mouse as well as during postnatal development.
A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila
Authors: Oikawa Izumi , Kondo Shu , Hashimoto Kao , Yoshida Akiho , Hamajima Megumi , Tanimoto Hiromu , Furukubo-Tokunaga Katsuo , Honjo Ken
Published: June 2023

Nociception is a neural process that animals have developed to avoid potentially tissue-damaging stimuli. While nociception is triggered in the peripheral nervous system, its modulation by the central nervous system is a critical process in mammals, whose dysfunction has been extensively implicated in chronic pain pathogenesis. The peripheral mechanisms of nociception are largely conserved across the animal kingdom. However, it is unclear whether the brain-mediated modulation is also conserved in non-mammalian species. Here, we show that Drosophila has a descending inhibitory mechanism of nociception from the brain, mediated by the neuropeptide Drosulfakinin (DSK), a homolog of cholecystokinin (CCK) that plays an important role in the descending control of nociception in mammals. We found that mutants lacking dsk or its receptors are hypersensitive to noxious heat. Through a combination of genetic, behavioral, histological, and Ca2+ imaging analyses, we subsequently revealed neurons involved in DSK-mediated nociceptive regulation at a single-cell resolution and identified a DSKergic descending neuronal pathway that inhibits nociception. This study provides the first evidence for a descending modulatory mechanism of nociception from the brain in a non-mammalian species that is mediated by the evolutionarily conserved CCK system, raising the possibility that the descending inhibition is an ancient mechanism to regulate nociception.
Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission
Authors: Sapiro Anne L. , Hayes Beth M. , Volk Regan F. , Zhang Jenny Y. , Brooks Diane M. , Martyn Calla , Radkov Atanas , Zhao Ziyi , Kinnersley Margie , Secor Patrick R. , Zaro Balyn W. , Chou Seemay
Published: June 2023

Borrelia burgdorferi
(
Bb
), the causative agent of Lyme disease, adapts to vastly different environments as it cycles between tick vector and vertebrate host. During a tick bloodmeal,
Bb
alters its gene expression to prepare for vertebrate infection; however, the full range of transcriptional changes that occur over several days inside of the tick are technically challenging to capture. We developed an experimental approach to enrich
Bb
cells to longitudinally define their global transcriptomic landscape inside nymphal
Ixodes scapularis
ticks during a transmitting bloodmeal. We identified 192
Bb
genes that substantially change expression over the course of the bloodmeal from one to four days after host attachment. The majority of upregulated genes encode proteins found at the cell envelope or proteins of unknown function, including 45 outer surface lipoproteins embedded in the unusual protein-rich coat of
Bb
. As these proteins may facilitate
Bb
interactions with the host, we utilized mass spectrometry to identify candidate tick proteins that physically associate with
Bb
. The
Bb
enrichment methodology along with the
ex vivo Bb
transcriptomes and candidate tick interacting proteins presented here provide a resource to facilitate investigations into key determinants of
Bb
priming and transmission during the tick stage of its unique transmission cycle.
A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury
Authors: Li Tingting , Shi Wenwen , Ho Margaret S. , Zhang Yong Q.
Published: June 2023

Traumatic brain injury (TBI) caused by external mechanical forces is a major health burden worldwide, but the underlying mechanism in glia remains largely unclear. We report herein that
Drosophila
adults exhibit a defective blood-brain-barrier (BBB), elevated innate immune responses, and hypertrophy of astrocytes upon consecutive strikes with a high-impact trauma device. RNA sequencing (RNA-seq) analysis of these astrocytes revealed upregulated expression of genes encoding PDGF and VEGF receptor-related (Pvr, a receptor tyrosine kinase (RTK)), adaptor protein complex 1 (AP-1, a transcription factor complex of the c-Jun N-terminal Kinase (JNK) pathway) composed of Jun-related antigen (Jra) and kayak (kay), and matrix metalloproteinase 1 (Mmp1) following TBI. Interestingly, Pvr is both required and sufficient for AP-1 and Mmp1 upregulation, while knockdown of AP-1 expression in the background of Pvr overexpression in astrocytes rescued Mmp1 upregulation upon TBI, indicating that Pvr acts as the upstream receptor for the downstream AP-1–Mmp1 transduction. Moreover, dynamin-associated endocytosis was found to be an important regulatory step in downregulating Pvr signaling. Our results identify a new Pvr–AP-1–Mmp1 signaling pathway in astrocytes in response to TBI, providing potential targets for developing new therapeutic strategies of TBI.

The study provided RNA-seq data of astrocytes following traumatic brain injury (TBI)Genes involved in endocytic trafficking are upregulated in astrocytes after TBIA new Pvr–AP-1–Mmp1 pathway is activated in astrocytes following TBI.Inhibition of endocytosis in astrocytes upregulates the Pvr–AP-1–Mmp1 signaling.
β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
Authors: Daly Carole , Guseinov Akim Abdul , Hahn Hyunggu , Wright Adam , Tikhonova Irina G , Thomsen Alex Rojas Bie , Plouffe Bianca
Published: June 2023

The vasopressin type 2 receptor (V2R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V2R activates Gαs and Gαq/11, which is followed by robust recruitment of β-arrestins and receptor internalization into endosomes. Unlike canonical GPCR signaling, the β-arrestin association with the V2R does not terminate Gαs activation, and thus, Gαs-mediated signaling is sustained while the receptor is internalized. Here, we demonstrate that this V2R ability to co-interact with G protein/β-arrestin and promote endosomal G protein signaling is not restricted to Gαs, but also involves Gαq/11. Furthermore, our data imply that β-arrestins potentiate Gαs/Gαq/11 activation at endosomes rather than terminating their signaling. Surprisingly, we found that the V2R internalizes and promote endosomal G protein activation independent of β-arrestins to a minor degree. These new observations challenge the current model of endosomal GPCR signaling and suggest that this event can occur in both β-arrestin-dependent and -independent manners.
Gene–environment pathways to cognitive intelligence and psychotic-like experiences in children
Authors: Park Junghoon , Lee Eunji , Cho Gyeongcheol , Hwang Heungsun , Kim Bo-Gyeom , Kim Gakyung , Joo Yoonjung Yoonie , Cha Jiook
Published: June 2023

In children, psychotic-like experiences (PLEs) are related to risk of psychosis, schizophrenia, and other mental disorders. Maladaptive cognitive functioning, influenced by genetic and environmental factors, is hypothesized to mediate the relationship between these factors and childhood PLEs. Using large-scale longitudinal data, we tested the relationships of genetic and environmental factors (such as familial and neighborhood environment) with cognitive intelligence and their relationships with current and future PLEs in children. We leveraged large-scale multimodal data of 6,602 children from the Adolescent Brain and Cognitive Development Study. Linear mixed model and a novel structural equation modeling (SEM) method that allows estimation of both components and factors were used to estimate the joint effects of cognitive phenotypes polygenic scores (PGSs), familial and neighborhood socioeconomic status (SES), and supportive environment on NIH Toolbox cognitive intelligence and PLEs. We adjusted for ethnicity (genetically defined), schizophrenia PGS, and additionally unobserved confounders (using computational confound modeling). Our findings indicate that lower cognitive intelligence and higher PLEs are significantly associated with lower PGSs for cognitive phenotypes, lower familial SES, lower neighborhood SES, and less supportive environments. Specifically, cognitive intelligence mediates the effects of these factors on PLEs, with supportive parenting and positive school environments showing the strongest impact on reducing PLEs. This study underscores the influence of genetic and environmental factors on PLEs through their effects on cognitive intelligence. Our findings have policy implications in that improving school and family environments and promoting local economic development may enhance cognitive and mental health in children.
Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
Authors: Kairouani Alicia , Pontier Dominique , Picart Claire , Mounet Fabien , Martinez Yves , Le-Bot Lucie , Fanuel Mathieu , Hammann Philippe , Belmudes Lucid , Merret Remy , Azevedo Jacinthe , Carpentier Marie-Christine , Gagliardi Dominique , Couté Yohann , Sibout Richard , Bies-Etheve Natacha , Lagrange Thierry
Published: June 2023

Deciphering the mechanism of secondary cell wall/SCW formation in plants is key to understanding their development and the molecular basis of biomass recalcitrance. Although transcriptional regulation is essential for SCW formation, little is known about the implication of post-transcriptional mechanisms in this process. Here we report that two bonafide RNA-binding proteins homologous to the animal translational regulator Musashi, MSIL2 and MSIL4, function redundantly to control SCW formation in Arabidopsis. MSIL2/4 interactomes are similar and enriched in proteins involved in mRNA binding and translational regulation. MSIL2/4 mutations alter SCW formation in the fibers, leading to a reduction in lignin deposition, and an increase of 4-O-glucuronoxylan methylation. In accordance, quantitative proteomics of stems reveal an overaccumulation of glucuronoxylan biosynthetic machinery, including GXM3, in the msil2/4 mutant stem. We showed that MSIL4 immunoprecipitates GXM mRNAs, suggesting a novel aspect of SCW regulation, linking post-transcriptional control to the regulation of SCW biosynthesis genes.
Endoscopic Findings of Common Gastritis in Koreans
Authors: Oh Jung-Hwan
Published: June 2023

In 2013, the Japan Gastroenterological Endoscopy Society introduced the Kyoto classification of gastritis, which is useful to predict Helicobacter pylori infection based exclusively on endoscopic findings. Based on the Kyoto classification of gastritis, gastric mucosal atrophy, endoscopic intestinal metaplasia, hypertrophic gastric folds, nodularity, and diffuse redness may be associated with gastric cancer and H. pylori infection, which are common endoscopic findings in Koreans. Atrophy and intestinal metaplasia are associated with gastric cancer and therefore require attention. Hypertrophic gastric folds, nodularity, and diffuse redness can be associated with current H. pylori infection. The Kyoto scoring system, which is based on endoscopic findings is useful to predict current H. pylori infection and gastric cancer in the absence of biopsy evaluation in clinical settings. A therapeutic strategy for H. pylori infection based on the Kyoto score is expected to reduce the incidence of gastric cancer in Korea and Japan. In this study, we investigated the endoscopic findings commonly observed in Koreans among those defined by the Kyoto classification of gastritis.
Unveiling sex-based differences in developing propionic acid-induced features in mice as a rodent model of ASD
Authors: Kamalmaz Nasreen , Ben Bacha Abir , Alonazi Mona , Albasher Gadah , Khayyat Arwa Ishaq A. , El-Ansary Afaf
Published: June 2023

Background

Males are more likely to develop autism as a neurodevelopmental disorder than females are, although the mechanisms underlying male vulnerability are not fully understood. Therefore, studying the role of autism etiologies considering sex differences in the propionic acid (PPA) rodent model of autism would build greater understanding of how females are protected from autism spectrum disorder, which may be used as a treatment strategy for males with autism.

Objectives

This study aimed to investigate the sex differences in oxidative stress, glutamate excitotoxicity, neuroinflammation, and gut microbiota impairment as etiological mechanisms for many neurological diseases, with specific reference to autism.

Method

Forty albino mice were divided into four groups of 10 animals each with two control and two treated groups of both sexes received only phosphate-buffered saline or a neurotoxic dose of PPA (250 mg/kg body weight) for 3 days, respectively. Biochemical markers of energy metabolism, oxidative stress, neuroinflammation, and excitotoxicity were measured in mouse brain homogenates, whereas the presence of pathogenic bacteria was assessed in mouse stool samples. Furthermore, the repetitive behavior, cognitive ability, and physical-neural coordination of the animals were examined.

Results

Collectively, selected variables related to oxidative stress, glutamate excitotoxicity, neuroinflammation, and gut bacteria were impaired concomitantly with altered behavior in PPA-induced rodent model, with males being more susceptible than females.

Conclusion

This study explains the role of sex in the higher vulnerability of males to develop autistic biochemical and behavioral features compared with females. Female sex hormones and the higher detoxification capacity and higher glycolytic flux in females serve as neuroprotective contributors in a rodent model of autism.
Effects of sports intervention on aggression in children and adolescents: a systematic review and meta-analysis
Authors: Yang Yahui , Zhu Hao , Chu Kequn , Zheng Yue , Zhu Fengshu
Published: June 2023

Objective

To explore the impact of sports on aggression in children and adolescents and analyze whether different conditions in the intervention, such as type of sports, or intervention duration, have different influences on the effect of interventions.

Method

The study protocol was registered in PROSPERO (CRD42022361024). We performed a systematic search of Pubmed, Web of Science, Cochrane library, Embase and Scopus databases from database inception to 12 October 2022 for all studies written in English. Studies were included if they met the following PICO criteria. All analyses were carried out using the Review Manager 5.3 Software. We summarized aggression, hostility and anger scores using SMDs. Summary estimates with 95% confidence intervals were pooled using DerSimonian-Laird random effects model or fixed effects model according to between-study heterogeneity.

Results

A total of 15 studies were deemed eligible for inclusion in this review. The overall mean effect size indicated that sport interventions was associated with lower aggression (SMD = −0.37, 95% CI [−0.69 to −0.06], P = 0.020; I2 = 88%). Subgroup analyses showed that non-contact sports were associated with lower aggression (SMD = −0.65, 95% CI [−1.17 to −0.13], P = 0.020; I2 = 92%) but high-contact sports were not (SMD = −0.15, 95% CI [−0.55 to 0.25], P = 0.470; I2 = 79%). In addition, when intervention duration <6 months, sport interventions was associated with lower aggression (SMD = −0.99, 95% CI [−1.73 to −0.26], P = 0.008; I2 = 90%) and when intervention duration ≥ 6 months, sport interventions was not associated with lower aggression (SMD = −0.08, 95% CI [−0.44 to −0.28], P = 0.660; I2 = 87%).

Conclusion

This review confirmed that sports intervention can reduce the aggression of children and adolescents. We suggested that schools can organize young people to participate in low-level, non-contact sports to reduce the occurrence of bullying, violence and other aggression-related adverse events. Additional studies are needed to determine which other variables are associated with aggression in children and adolescents, in order to develop a more detailed and comprehensive intervention programme to reduce their aggression.
The behavior of sympatric sea urchin species across an ecosystem state gradient
Authors: Belleza Dominic Franco C. , Urae Takeshi , Tanimae Shin-ichiro , Toyama Kento , Isoda Akari , Nishihara Gregory N.
Published: June 2023

Background

In temperate macroalgal forests, sea urchins are considered as a keystone species due to their grazing ability. Given their potential to shape benthic communities, we monitored the habitat use by three sympatric sea urchin species and compared their behaviors in a vegetated habitat (VH) and an adjacent isoyake habitat (IH).

Methods

We monitored the environmental conditions and sea urchin density along deep and shallow transects of the VH and IH for over a year. The benthic rugosity at both sites were also surveyed. A mark-recapture experiment was conducted on the two most abundant sea urchins, Diadema setosum and Heliocidaris crassispina, to elucidate sea urchin movement patterns and group dynamics.

Results

We found that exposure to waves was highest at the VH while the IH was sheltered. The deep IH experienced the least amount of light due to high turbidity. Water temperature patterns were similar across sites. The VH benthic topography was more rugose compared to the smoother and silt-covered IH substate. Peak macroalgal bloom occurred three months earlier in IH, but macroalgae persisted longer at the shallow VH. Among the sympatric sea urchins, H. crassispina was most abundant at the shallow VH and was observed in pits and crevices. The most abundant across IH and in the deep VH was D. setosum, preferring either crevices or free-living, depending on hydrodynamic conditions. The least abundant species was D. savignyi, and most often observed in crevices. Small and medium sea urchins were most often observed at the IH site, whereas larger sea urchins were more likely observed at the VH. The mark-recapture study showed that D. setosum was found to displace further at the IH, and H. crassispina was more sedentary. Additionally, D. setosum was always observed in groups, whereas H. crassispina was always solitary.

Discussion

The behaviors of sympatric urchins, Diadema savignyi, D. setosum and H. crassispina, differed in response to changes in the benthic environment and physical conditions. Sea urchin displacement increased when rugosity and wave action were low. Habitat preference shifted to crevices in seasons with high wave action. In general, the mark-recapture experiment showed that sea urchins displaced further at night.
Descarte do conhecimento em cartórios de Mossoró/RN
Authors: Batista Júnior Antonio , de Menezes Edivaldo Rabelo , Rego Filho Francisco Souza , De Sousa Neto Pedro Balduino , De Souza Rafael Demetrius Rodrigues , De Moura Rosalynn Rebouças , de Jesus Silvia Manoela Santos , Costa Yascara Pryscilla Dantas
Published: June 2023

Os cartórios estão se adaptando a uma norma do governo que exige a digitalização de documentos, sendo assim, a pesquisa tem como objetivo avaliar a percepção dos gestores sobre o descarte do conhecimento. A pesquisa corresponde a uma abordagem qualitativa e quantitativa de um estudo de múltiplos casos, caracterizando-se como uma pesquisa descritiva. Os dados foram tratados de acordo com os procedimentos determinados pelo modelo de Bukowitz e Williams (2002). De acordo com os resultados, os cartórios nos quais obtiveram os melhores índices praticam uma política de compartilhamento através de meios eletrônicos, utilizando assim a Tecnologia da Informação (TI) como um instrumento facilitador na execução da tarefa, entretanto os desempenhos insatisfatórios das demais organizações refletem a persistência em considerar o conhecimento que não possui mais utilidade atual e na resistência em obter novos conhecimentos.
O planejamento e a gestão de micro e pequenas empresas do seguimento de estética em Palmas – TO
Authors: Castro Alexia Diamond Sant'Ana , Borges Cejana Marques , Bitar Alan Barros , Lima Mônica de Souza , Campos André Ernesto , De Faria Denilda Caetano , Do Amordivino Stelamar , Sousa Arlan Marcos Lima
Published: June 2023

O presente artigo tem por objetivo analisar a utilização de ferramentas de planejamento e gestão nas micro e pequenas empresas, no município de Palmas - TO. Foi elaborado a partir de pesquisa bibliográfica e análise de dados colhidos através da aplicação de um questionário. Tendo por tema: “O planejamento e a gestão de micro e pequenas empresas do seguimento de estética em Palmas – TO”, o levantamento permite afirmar que as empreendedoras utilizam algumas ferramentas de gestão e planejamento, porém não existe um conhecimento e aplicação sistematizado acerca das ferramentas de gestão e planejamento, onde conclui-se que a gestão e o planejamento estão preteridos no processo de empreender, dificultando o estabelecimento e crescimento da empresa.