bluuebunny/crossref_metadata_2025 huggingface dataset:
Современное состояние исследований в области фармакологии микроводорослей (обзор)
Authors: Mitishev A. , Vodop'janova O. , Kurdyukov E. , Semenova E. , Fednina A.
Published: July 2023

Микроводоросли являются возобновляемыми, устойчивыми и экономически выгодными источниками биотоплива, биологически активных соединений (БАС) для медицинской, фармацевтической, косметической и пищевой промышленности. Проанализирована и обобщена информация о результатах исследований отечественных и зарубежных ученых, касающаяся фармакологических эффектов БАС микроводорослей. Показано, что БАС имеют широкий спектр фармакологических (антибактериальных, противовирусных, противоопухолевых, антиоксидантных, регенерирующих, гипотензивных, иммуностимулирующих, противовоспалительных) эффектов. Описаны основные фармакологические эффекты БАС.
Таблетированные формы биологических лекарственных препаратов (технологические особенности приготовления)
Authors: Комиссаров А. , Волох О. , Овчинникова М. , Бибиков Д. , Синицына Н. , Глазкова Е. , Гиненко Г. , Никифоров А.
Published: July 2023

Представлен обзор отечественной, зарубежной научной и патентной литературы, а также нормативных документов, посвященных вопросам технологических особенностей производства биологических лекарственных препаратов (БЛП) в форме таблеток (период поиска составил от 90-х годов XX в. по настоящее время). Дано представление о качественном и количественном составе вспомогательных веществ, применяемых для формирования таблеточной смеси и ее прессования. Дан обзор особенностей основных этапов получения таблеток и проанализированы их отличительные черты. Систематизированы сведения о БЛП в форме таблеток, зарегистрированных в РФ. Продемонстрировано влияние технологических характеристик операций формирования таблеточной смеси и ее прессования на качество препаратов. Выявлено, что верный выбор состава вспомогательных веществ позволяет избежать ухудшения качества препаратов. Представленный обзор научных и патентных изданий предоставляет возможность принять во внимание изложенные в статье факторы при создании технологии приготовления БЛП в форме таблетки.
Data on Jeroboam II’s Reign Supplied by the History of Solomon
Authors: Na’aman Nadav
Published: July 2023

The article examines the potential of episodes related in the biblical history of Solomon to serve as sources for the history of Jeroboam II, King of Israel. It first suggests that the “Acts of Solomon”, the source available to the author of Solomon’s history, was written in Judah in the late eighth century BCE, after the fall of the Northern Kingdom. It then examines five episodes that depict Solomon’s operations: (a) his district list (1 Kgs 4:7–19); (b) the list of six cities that he built (9:15b, 17b–18); (c) the sails he initiated from the Gulf of Eilat to Ophir (9:26–28; 10:11–12, 16–22); (d) his presentation as mediator in the international trade of horses and chariots (1 Kgs 10:28–29); and (e) the concept of the United Monarchy as reflection of Jeroboam II’s kingdom. The article concludes that of these episodes, only the account of Solomon’s sails to Ophir rests on the reality of Jeroboam’s time and memorialized his cooperation with the King of Tyre in the maritime sail to Ophir and the extraction of gold from this remote country.
Wer schrieb und wer las den Psalter?
Authors: Grund-Wittenberg Alexandra
Published: July 2023

Im Blick auf Gebrauch und Trägerkreise des Psalters in seiner formativen Phase wurden, in Variation, zwei unterschiedliche Positionen vertreten. Die eine sieht dem zweiten Tempel und seiner Liturgie nahestehende Kreise am Werk, die andere geht von der Tradierung in schriftgelehrten Kreisen und der privaten lectio continua eines „Lesepsalters“ aus. Der vorliegende Beitrag nähert sich der Frage nach Gebrauch und Tradentenkreisen des Psalters in seiner formativen Phase von außen und fragt nach einschlägigen Einsichten aus antiken Quellen, darunter den Textfunden vom Toten Meer, die weiteren Aufschluss über Gebrauch und Trägerkreise des Psalters geben können.

With regard to the use and compilers of the Psalter in its formative phase, two different positions are held in recent research. One finds the compilers among groups related to the second temple, its cult and liturgy, the other assumes the transmission of the psalter in scholarly circles, the Psalms being used in individual lectio continua. The present study explores the external evidence regarding the scribal culture in antiquity and especially the use of Psalms in the findings from the Judean desert that can provide further information about the use and compilers of the Psalter.
Infrastrukturelle Dramaturgien: Ästhetische Relationen im Nachleben der Gewaltgeschichte
Authors: Gabriel Leon
Published: July 2023

Entgegen ihrer einstmaligen Ausrichtung im Geiste des deutschen Idealismus war und ist Dramaturgie immer schon aufs Engste mit den Infrastrukturen des Theater- und Kunstmachens verwoben. Denn über den bloßen (dramatischen) Narrationsverlauf hinaus bezeichnet Dramaturgie sowohl die ästhetische Strukturierung von Raum und Zeit als auch das Arbeitsfeld an der Schnittstelle von künstlerischem Ausdruck und Produktionsbedingungen – beides bündelt eine zentrale, aber versteckte politische Funktion. Dramaturgie ist die je spezifische Arbeit an diesem Verhältnis von ästhetischer Form und epistemischen, sozialen und materiellen Bedingungen. Der Beitrag erläutert dieses Verhältnis, indem er die Arbeitsweise und Ästhetik des kolumbianischen Theaterkollektivs Mapa Teatro anhand ihres jüngsten Projektes La Luna en el Amazonas untersucht. Gezeigt wird, inwiefern Dramaturgien und Infrastrukturen aufgrund ihrer relationalen Komponente zusammengedacht werden können, und wie durch konkrete dramaturgische Arbeit Infrastrukturen in ihren gegenwärtigen sowie historisch bedingten gewaltsamen Verhältnissen verhandelt werden. Sowohl die Inszenierung als auch Mapa Teatros Arbeitsweise sind deshalb Teil einer ‚infrastrukturellen Dramaturgie‘, weil hier die grundlegend relationale Arbeit (Dramaturgie) bezüglich spezifischer relationaler Gefüge zugespitzt wird (Infrastrukturen) – nicht zuletzt mit Blick auf extraktivistische Gewalt in der Vielschichtigkeit ihres Nachlebens.
La experiencia esclavista en los entramados económicos y sociales urbanos. El caso de la familia Soto
Authors: López Villagra Edgardo Darío
Published: July 2023

El artículo se referirá a las singularidades de la experiencia esclavista urbana en los entramados económicos y sociales a finales del siglo XVIII y principios del siglo XIX. En particular se analiza el caso de la familia Soto en función de evidenciar diferentes rasgos que permiten caracterizarla como parte de las élites locales. Así, su estudio se fundamenta en su relevancia en la historia local y significativa influencia en la conformación y organización de Goya. En función de lo cual se realiza un análisis historiográfico y un estudio de hermenéutica jurídica, que incluye un archivo privado inédito de la familia Soto, que posibilita aprehender socio-históricamente la esclavitud en la subregión correntina. De esta manera, se realiza un análisis comparativo del macro contexto de la época en consideración de las colonias no españolas e hispanoamericanas. En general, en Estados Unidos y Brasil el trabajo del esclavo/s negros/as se vinculó preponderantemente a la explotación económica de las plantaciones. Empero, la tendencia permite establecer una diferenciación respecto a Hispanoamérica, donde la esclavitud era fundamentalmente urbana y doméstica. No obstante, no se descarta que, en menor medida, coexistieron otras modalidades de esclavitud en ambos casos. En este marco, el análisis que va de lo general a lo particular, se sitúa el estudio de las características de la esclavitud urbana, la economía y sociedad en el Río de la Plata, en la subregión correntina y en los orígenes de la ciudad de Goya.
ANALISIS SEMIOTIK PENGGUNAAN EMOSION DAN MAKNANYA DALAM BAHASA ARAB
Authors: Yusuf Rahmawati
Published: July 2023

Artikel ini membahas tentang makna dalam penggunaan emosion dari segi analisis semiotik bahasa Arab. Tujuan dari penelitian ini adalah menganalisis makna dari setiap emosion yang dilihat dari makna Indonesia dan Arab, yang kemudian ditafsirkan berdasarkan pendekatan semiotik. Metode yang digunakan pada artikel ini adalah metode library research (kajian kepustakaan) yaitu studi untuk cara mengumpulkan data berdasarkan Sumber data primer diperoleh dari sejumlah emosion yang ada pada media instagram dan whatsup, sedangkan data sekunder bersumber sejumlah artikel, buku, majalah dan lain sebagainya. Hasil penelitian menunjukan bahwa: jumlah emoticon yang diperoleh sebanyak 50 emoticon, yang di klasifikasikan berdasarkan ekspresi wajah, a) gembira, b) sedih, c) marah, d) abstrak. Pada artikel ini memiliki hasil pembahasan yaitu adanya makna yang terkandung setiap emosion seperti marah, tertawa, sedih, dan beberapa emosion lainya. Kesimpulan dari penelitian ini adalah dengan menggunakan pendekatan semiotik, emosion tidak hanya dipakai sebagai icon di media sosial saja, namun masing-masing dari emosion tersebut memiliki makna yang terkandung di dalamnya.
فعّالية استخدام المعجم الإلكتروني "المعاني" لترقية كفاءة الطلبة في ترجمة النصوص العربية
Authors: Rusliyani Dewi
Published: July 2023

مستخلص البحث

إن مادة الترجمة هي مادة مفروضة  في قسم تعليم اللغة العربية بجامعة سالاتيجا الإسلامية الحكومية ولها دور مهم في دعم كفاءة الطلبة عن المهارات اللغوية الأربعة. وفي هذا البحث، تجد الباحثة المشكلات لدى الطلبة بقسم تعليم اللغة العربية في الترجمة، كمثل عدم معرفة الطلبة عن المفردات العربية ومعانيها، لم يتمكن الطلبة في التمييز بين جملة اسمية و جملة فعلية، لم يقدر الطلبة على تنظيم الجمل في ترجمتها.

الأهداف في هذ البحث هي : (1) لمعرفة عملية استخدام المعجم الإلكتروني "المعاني" في تعليم مادة الترجمة بقسم تعليم اللغة العربية بجامعة سالاتيجا الإسلامية الحكومية(2) لقياس فعالية استخدام المعجم الإلكتروني "المعاني" لترقية كفاءة الطلبة في ترجمة النصوص العربية. ومنهج البحث المستخدم في هذا البحث هو المنهج التجريبي، ويستخدم هذا البحث التجريبي بشكل دراسة الحالة الواحدة بمدخل الكمي. وأما الأسلوب لجمع البيانات المستخدمة هي الملاحظة والمقابلة والاختبار(الاختبار القبلي والاختبار البعدي) والاستبانة.

والنتيجة لهذا البحث هي: (1) تعليم مادة الترجمة بقسم تعليم اللغة العربية بجامعة سالاتيجا الإسلامية الحكومية على الخطوات منها: تقسم الباحثة القرطاس للنصوص العربية، وتطلب الباحثة الطلبة القيام بثلاث مراحل: الأولى: مرحلة التحليل، باعتبارها محاولة لفهم النص المصدر من خلال الدراسات اللغوية والمعنى ولفهم المواد المترجمة، الثانية: مرحلة نقل المعنى في النص المصدر بمساعدة استخدام المعجم الإلكتروني "المعاني"، الثالثة: مرحلة إعادة التحقيق والتعديل في المحاولة على حصول النتيجة النهائية للترجمة في اللغة الإندونيسية، وبعدها  تقوم الباحثة بالتفتيش والتصحيح عن ترجمة الطلبة للنصوص العربية(2) تعرف فعالية استخدام المعجم الإلكتروني "المعاني" لترقية كفاءة الطلبة في ترجمة النصوص العربية . فمن نتائج ت-الإحصائي الذي يوضح أن نتائج (t-hitung) هي (12،450) أكبر من (t-table)المستوى المعنوي (1% = 2،86) وكذلك أكبر من نتيجة المستوى المعنوى (5% = 2،09)، وذلك بمعنى أن H0 مردود، H1مقبول أي أن فرض هذا البحث مقبول. والخلاصة أن استخدام المعجم الإلكتروني "المعاني"  لترقية كفاءة الطلبة في ترجمة النصوص العربية  فعال.

الكلمة الرئيسية:  المعجم الإلكتروني "المعاني"، الترجمة.
THE SOCIOLINGUISTIC ANALYSIS OF CODE-MIXING TYPES IN LIVY RENATA AND NIRINA ZUBIR’S UTTERANCES IN “TS MEDIA” PODCAST
Authors: Sagala Juni Arta , Sihombing Agustina , Rudianto Gaguk
Published: July 2023

This research examined the code-mixing found on YouTube. Because many people nowadays use YouTube to express their creativity, this article used YouTube. The aims of this research were to determine the types of code-mixing and the code-mixing factors that influence children in south Jakarta to mix their language. The researchers choose the data source from TS Media’s YouTube, Livy Renata's utterance in the video was used the most. This research was revealed by the researchers using Muysken’s theory. The qualitative descriptive method was used in the research to analyze the different types of code-mixing and the dominant category used by Livy's utterance. Data were gathered through observation. The data was derived from a video that was uploaded to TS Media's YouTube channel. There are (8) insertions, (4) alternation, and (3) congruent lexicalization as a consequence of this research. They all use varying amounts of code-mixing in their speakers' and listeners' utterances. In this video, there are so many mixes in language and the researchers finding revealed that insertion was the most common type of code-mixing used by speakers and hearers in the video TS media's YouTube. It was followed by the second type, alternation, and the last type, congruent lexicalization.
THE LONELINESS OF A FEMALE CHARACTER IN RACHAEL LIPPINCOTT ET. AL.’S NOVEL FIVE FEET APART
Authors: Arifia Della Muftafrisda , Hartanto Erika Citra Sari
Published: July 2023

This study focuses on the loneliness that is faced by the female main character, Stella Grant, in the Five Feet Apart novel. There are two focuses in analyzing this study, the first is the causes of Stella Grant’s loneliness, and the second is the copes of Stella Grant’s loneliness. To analyze this study, the writer uses loneliness theory by Peplau & Perlman (1979 & 1981). The writer uses a psychoanalysis approach about loneliness theory. The author’s narration and also dialogue in the novel help the writer to know the causes and the copes of the loneliness that Stella Grant faced that is suitable with the theory. The causes of loneliness are physical separation, death, unemployment, and the end of the relationship. The biggest influence that causes Stella to feel lonely is due to physical separation and the death of the closest person. Physical separation makes her feel alone and abandoned. While the death of the closest person makes her lose her direction and lack the spirit of life. The copes of loneliness are adaptation, task choice, and standards for evaluating social relationships, ways of using existing relationships more fully, ways of forming new relationships, and replacement relationships. Meanwhile, the way that gives the big impact for Stella to overcome her loneliness is forming a new relationship and task choice. Forming a new relationship helps Stella to find someone new in her life so it can give a new color to her life. Then, task choice can help her be busier and forget her loneliness.
MICHAEL OHER’S PERSONALITY DEVELOPMENT IN MICHAEL LEWIS’S THE BLIND SIDE
Authors: Lah Herni , Supsiadji Mateus Rudi
Published: July 2023

This study is about personality traits and personality development of the main character in The Blind Side by Michael Lewis.  The research uses two theories to analyze. The first theory is big five theory by Robert McCrea and Paul Costa to analyze Michael Oher’s personality traits. The second theory is by Elizabeth B. Hurlock to analyze Personality developments which consist of eight determinants. The study uses a psychoanalytical approach and descriptive qualitative method to analyze the novel. The results of the analysis show that the main character in The Blind Side has several personality traits, along with the journey of his life, he experiences personality development, which changed from someone who was always alone, desperate, and hopeless slowly becoming someone who is confident,  passion, enthusiasm to start his day and strong ambition for a better future.
NORA’S CHARACTER DEVELOPMENT AFTER APPARENT DEATH IN MATT HAIG’S THE MIDNIGHT LIBRARY
Authors: Ratu Praditha Juang Galuh , Andayani Ambar
Published: July 2023

This study aims to analyze the development of the main character, Nora, in Matt Haig’s the Midnight  Library.  The  development  of  Nora’s  character  begins  to  look  after  she  experiences  the apparent death when she is between life and death. Apparent death is an experience where someone is transferred into another life. The writer uses a descriptive qualitative method and an intrinsic approach to analyze Nora’s character development which is  influenced by  the conditions and circumstances experienced by Nora. The data of this study is taken from the words and dialogues in Matt Haig’s the Midnight Library which shows the characters and character development of the main character, Nora. In analyzing the data, the writer uses the theory of character development by Perrine (2018). The analysis reveals that the apparent death has influenced the development of Nora’s character. At the beginning of the story, the writer finds out that Nora is a dispirited, petty-minded, pessimistic, ungrateful, and self- blameful person. After she experiences apparent death, she begins to realize the true meaning of her life. And then she becomes an open-minded, optimistic, grateful, and happier person after she experiences something big in her life which is when she is between life and death.
THE ANALYSIS OF CONNOTATIVE MEANING FOUND IN PERCY BYSSHE SHELLEY’S POEMS.
Authors: Rahman Adi
Published: July 2023

Most people find difficulties while studying and reading poems because a poem is full of meanings and symbols. Understanding a poem is not as easy as understanding texts of books whose meaning actually depend on the real text. To understand a poem is not enough only with lexical meaning. Thus, the reader should understand other meanings. One of the meaning that can be used to understand poems is connotative meaning because that meaning depends on what is referred to. In this study, the researcher is interested in analyzing Percy Bysshe Shelley’s poems by using connotative meaning theory and message. The objectives of this study are (1) To describe the connotative meanings are used in Percy Bysshe Shelley poems and (2) To know the message of Percy Bysshe Shelley poems which are performed to the readers. In this research, the researcher focus on connotative theory from Geoffrey leech, (2003:24). The researcher also used figurative language theory from Tengso Tjahjonobecause the theory is more detail than others. He divided figurative language into four types in generally. Those are comparison, affirmation, satire, and contradiction. Based on the result of the analysis, the researcher found in Percy Bysshe Shelley’s selected poems used connotative meaning in each line of his poems to tell the relationship between human, nature, and love. He also used various figurative language such as metaphor, personification, hyperbole, and smile to create a purpose in this poems by equating and comparing with nature around him that has a certain relationship.
PERSONALITY DEVELOPMENT OF EDWARD TULANE IN KATE DICAMILLO’S THE MIRACULOUS JOURNEY OF EDWARD TULANE
Authors: Rayana Sholta Aryas , Supsiadji Mateus Rudi
Published: July 2023

The researcher analysis Edward Tulane as the character who has experienced his personality development in his life in the novel The Miraculous Journey of Edward Tulane. The researcher formulates two research problems in this study, the objectives are to to find out of Edward Tulane’s personality and to find out Edward Tulane’s personality development in DiCamillo’s novel entitled The Miraculous Journey of Edward Tulane. The research method applied in this study is qualitative with an intrinsic approach. The study's data item is derived from the dialogue. The discussion focuses on Edward Tulane, the main character, who goes on a miraculous journey that changes his entire life. Life experience is able to change someone’s personality from a bad to a good personality. Experience and an event literally can change Edward Tulane’s life and his personality. The finding of this study is Edward Tulane's personality is changing from arrogant to a caring rabbit china doll.
MENCAPAI PRODUKSI KAKAO BERKELANJUTAN DI INDONESIA
Authors: Ibnu Muhammad
Published: July 2023

Indonesia has the potential to become a major exporter of cocoa in the world as well as to meet the needs of the domestic cocoa industry. However, the lack of availability of raw materials (cocoa beans) causes the processing industry to import cocoa beans from other countries. Indonesia has even been included in the five largest cocoa importing countries in the world. This raises questions about the sustainability of cocoa production in Indonesia. This research has two objectives. First, predicting the sustainability of cocoa production in Indonesia. Second, identify strategies or efforts that need to be done so that cocoa production in Indonesia can achieve a better level of sustainability. The first objective of the research was achieved by using quantitative methods, namely by analyzing trends in secondary data (from FAOSTAT) related to cocoa production, planted area, and cocoa productivity as well as cocoa exports and imports. The second objective of the research is achieved by reviewing the literature, especially reviewing the results of empirical research (and various publications by cocoa-related institutions) to identify potential strategies in order to improve the sustainability of Indonesian cocoa production. The results showed that productivity problems have a high level of urgency to be overcome. If not addressed, there is a possibility that Indonesia will become a net cocoa importer in the future (imports are greater than exports). Strategies to increase the sustainability of Indonesian cocoa production need to focus on increasing productivity through the use of superior cocoa seeds, focus on specific support for farmers' livelihoods, focus on improving the supporting environmental instruments that are still lacking (such as access to finance and inputs, facilities and infrastructure) rural areas, capacity building of farmer organizations, and extension services) and focus on the existence of strong institutions to ensure the functioning of partnerships between farmers/farmers' organizations and other parties.
Kelayakan Usaha Pengolahan Ikan Asin Dengan Mesin Pengering Sollar Cell
Authors: Tanjung Garist Sekar , Raden Achmad Djazuli  , Oki Wijaya
Published: July 2023

Tanjung Binga is the largest salted fish producing area in Belitung Regency. The abundance of fish production in this area allows fishermen to produce various types of processed fish to extend the shelf life of their catch, especially for products exported outside the island. One of the mainstay processed products of fishermen is salted fish. However, currently the problem in processing salted fish occurs in the drying process which is still carried out in open spaces with traditional drying methods using sunlight. So that during the rainy season, the drying process can be hampered, which will affect the quality of the salted fish products produced. Therefore, this study aims to analyze the feasibility of processing salted fish using a portable solar cell dryer. The methodology used is to evaluate the financial feasibility and sensitivity analysis. The results showed that the salted fish product had the eligibility criteria with a PBP value of 0.48 years; NPV of Rp 3,268,039,778; B/C ratio of 1.37; and an IRR of 208.3% under normal conditions. In scenario 1, this effort is still considered in the feasible criteria. In scenario 2 (raw materials increase, total production decreases, interest rates increase), then the business is no longer feasible. Thus the salted fish processing business using a drying machine which is intended for fishermen and salted fish business actors deserves to be continued.
A phenomenological study of the participant experience in clinical trials and the potential for subject care through open dialog.
Authors: Kitao Ryota
Published: July 2023

Using a phenomenological approach, this study aimed to understand how individuals experience participation in clinical trials from the perspective of participants by interviewing 11 experienced research participants. 
Analysts provided interpretive descriptions to share the narrative meaning of the participants’ experiences as participants of intervention trials. 
The results were organized into four categories: 1) decision to participate, 2) understanding the trial, 3) being marginalized, and 4) talking about meaning. The participants attach personal meaning to their participation experience. Their personal perspective of their willingness to participate and their unpleasant experiences may change through interactions with the researcher. Thus, the qualitative outcome reports will serve as a guide for ethical actions to be taken by researchers for the benefit of future participants.
Dynamics of glutathione- S-transferase gene expression in subacute liver damage caused by acrylamide and on the background of correction
Authors: Mukhammadieva G. F. , Yakupova T. G. , Karimov D. O. , Valova Ya. V. , Repina E. F. , Kudoyarov E. R.
Published: July 2023

The aim of the study was to study the effect of oxymethyluracil complex compounds on the expression of glutathione-S-transferase genes in rat liver under conditions of its toxic damage by acrylamide. Materials and methods. The animals were divided into 5 groups of 6 animals each: control, acrylamide, acrylamide + complex compound of oxymethyluracil with ascorbic acid (MG-1), acrylamide + complex compound of oxymethyluracil with sodium succinate (MG-2), acrylamide + complex compound of oxymethyluracil with acetylcysteine (MG-10). The drugs were administered 1 hour before exposure to the toxicant for 28 days. After the end of the experiment, the animals were decapitated, the liver was removed, which was frozen in liquid nitrogen. Real-time reverse transcription polymerase chain reaction was used to analyze gene expression. Results. Exposure to acrylamide did not significantly affect the expression of the GSTP1, GSTT1, and GSTM1 genes in the liver of rats, however, for all the studied genes, there was a tendency to increase the value of the studied indicator. Prophylactic administration of a complex compound of oxymethyluracil with sodium succinate (MG-2) led to a statistically significant decrease in the transcriptional activity of the GSTM1 gene under conditions of toxic damage to the liver by acrylamide. Conclusion. The results of the study indicate the ability of the MG-2 drug to suppress the expression of the GSTM1 gene in the liver of rats when exposed to acrylamide. Further research is needed to better understand the molecular mechanisms of acrylamide-induced toxicity and to develop new therapeutic approaches to treat liver pathology.
The significance of serum marker levels for assessing the status and prognosis of patients with inflammatory bowel disease
Authors: Kruchinina M. V. , Svetlova I. O. , Osipenko M. F. , Abaltusova N. V. , Gromov A. A. , Borisova A. V. , Kruchinina E. V.
Published: July 2023

Purpose of the work: to analyze the research performed in the last decade on the study of serum markers used to diagnose inflammatory bowel diseases (IBD), differential diagnosis of nosological forms of IBD, to predict the course of the disease, response to ongoing therapy, as well as to predict the recurrence of the disease. Materials and methods. A search was carried out in the text databases “Scopus”, “Web of Science”, “PubMed” using keywords from the literature sources of the last 10 years about blood serum biomarkers used for diagnosis, evaluation of therapeutic efficacy, monitoring of disease activity and evaluation of prognosis in patients with IBD. Results. Information on serological biomarkers of IBD, which are well known and widely used in clinical practice (C-reactive protein), recently discovered biomarkers (cytokines, antibodies and non-coding RNA), as well as recent advances in serological biomarkers (metabolomics, proteomics, oncostatin M, galectins), were analyzed, which are used in various aspects of the diagnosis of IBD. Since intestinal fibrosis significantly affects the prognosis in patients with IBD, data on serum markers of intestinal fibrosis are presented separately. Conclusion. Recently, serum biomarkers in patients with IBD have become the object of close attention, since they are minimally invasive, convenient, and relatively inexpensive than markers in biopsy specimens, other biological fluids, fecal, and respiratory tests. Despite an extensive list of studies conducted over the past 10 years, there are still no ideal serum biomarkers for the diagnosis of IBD. Serum and non-coding RNA profiling techniques are just beginning to develop, but offer great promise for clinical practice. A combination of different biomarkers may be useful to improve the efficiency of IBD diagnosis.
HFE hemochromatosis gene polymorphism and porphyria cutanea tarda
Authors: Krivosheev A. B. , Kondratova M. A. , Gurazheva A. A. , Maksimov V. N.
Published: July 2023

Purpose. To study the frequency of genotypes and alleles of C282Y and H63D mutations in the HFE gene in patients with porphyria cutanea tarde of the West Siberian region and their influence on the clinical and biochemical characteristics of the disease. Materials and methods. We observed 14 patients with porphyria cutanea tarde (PCT), who underwent a comprehensive general clinical and instrumental examination. The indicators of the excretory profile of porphyrin metabolism indicators were purposefully determined, a molecular genetic examination was carried out to determine the genotypes and alleles of the C282Y and H63D mutations of the hemochromatosis gene HFE. Results and discussion. Molecular genetic research found that the HFE gene mutation was found in 7 patients (50.0%). Polymorphism for the C282Y allele was found in 2 (14.3%) patients, and for the H63D allele - in 5 patients (35.7%). Risk factors for the manifestation of PCT included frequent alcohol consumption and chronic HCV infection. Genotype 1b was recorded more often (9 people), less often - genotype 3a (4 people). The excretory profile of porphyrin metabolism indices in patients of both groups exceeded the control values. Porphyrin metabolism parameters in patients without HFE gene mutations were significantly higher than those in patients without HFE gene mutations. Conclusions. Polymorphism of the hemochromatosis gene HFE in PCT was detected in 50% of patients. The most common mutation was the H63D allele. The level of porphyrin metabolism disorders in patients with HFE hemochromatosis gene mutations is significantly lower. The clinical picture of PCT in all observed patients did not differ. Chronic viral hepatitis C is assessed as a risk factor for the manifestation of PCT.
The ArthroMyoFascial Complex
Authors: Noten Karl , Amstel Robbert Nimal
Published: July 2023

The authors, Karl Noten and Robbert van Amstel coincided that the current fascial terminologies, approached from a musculoskeletal perspective, were overly complex for therapists, necessitating a need for clinical classification. Understanding the relationship between different types of fascia and their role in manual therapies becomes vital. The variety of fascial tissues is classified by the authors as superficial fascia, deep fascia, myofascia, and arthrofascia, depending on their proximity to the skin. The different fasciae act as a whole system combined with muscles and joints called the ArthroMyoFascial Complex. The ArthroMyofascial Complex is a comprehensive and integrated concept in clinical anatomy and biomechanics, emphasizing the interconnectedness of various anatomical structures surrounding a joint. Together, these distinct fascial components create a force-transmitting network that links the skin, muscles, bones, and all other tissues laying within this ArthoMyoFascial Complex. This classification and approach is important for all manual therapists.
Assessing the association between fertility rates and wellbeing: a two-way fixed effect study
Authors: Woolf Benjamin , Munafo Marcus Robert , Sallis Hannah , Yarmolinsky James
Published: July 2023

The conventional observational epidemiological literature suggests a negative effect of having children on wellbeing. A previous Mendelian randomisation study, a quasi-experimental method for appraising causal relationships in observational settings, found evidence of a positive association. This study aims to triangulate the Mendelian randomisation results using two-way fixed effect panel regression (TWFE). Fixed effects regression is analogous to matching an individual with themselves at another time, and therefore controls for time invariant confounding. TWFE additionally models a time trend, and therefore controls for linear time-varying confounding. Using data from the Our World in Data platform, we find a positive association between fertility rates and wellbeing from 164 countries over a 19-year period (2003 to 2021). Specifically, we found a 0.352 (95% CI 0.141 to 0.563) unit increase in wellbeing on the Cantril Ladder for every additional birth per 1,000 people. Sensitivity analyses failed to find evidence of meaningful residual confounding from measured potential time-varying confounders. The large E-value (2.399) for the point estimate implies that a single source of bias is unlikely to explain our results. This supports a positive association between fertility rates and wellbeing.
Sustainable irrigation reduces arsenic bioavailability in fluvio-alluvial soils promoting microbial responses, high rice productivity and economic profit
Authors: Majumdar Arnab , Upadhyay Munish Kumar , Giri Biswajit , Moulick Debojyoti , Sarkar Sukamal , Thakur Barun , Yadav Poonam , Sahu Kashinath , Srivastava Ashish Kumar , Buck Martin , Tibbett Mark , Jaiswal Manoj , Roychowdhury Tarit
Published: July 2023

Minimizing arsenic (74.92As33) loading into rice plants, we suggest adopting alternating wetting and drying (AWD) irrigation as a sustainable water management strategy allowing greater silicon (28.08Si14) availability. This two-year field-based project is the first report on AWD's impact on As-Si distribution in fluvio-alluvial soils of the entire Ganga valley (24 study sites divided into six Gangetic divisions), seasonal variance (pre-monsoon and monsoon), rice plant anatomy and productivity, soil microbial diversity, microbial gene ontology profiling, and cellular metabolic pathways. Under AWD to flooded and pre-monsoon to monsoon cultivations, respectively, As bioavailability was reduced by 8.71–9.25% and 25.68–26.13%. In the pre-monsoon and monsoon seasons, the rice grain yield under AWD improved by 8.41% and 9.96%, respectively proving the economic profitability. Compared to waterlogging, AWD proves to be the optimal soil condition for supporting soil microbial communities in rice fields, allowing diverse metabolic activities, As-resistance, and active expression of As-responsive genes and gene products. Finally, it is determined that by using AWD, the use of groundwater can be reduced, lowering the cost of pumping and field management and generating an economic profit for farmers. These combined assessments prove the acceptability of AWD for the establishment of multiple sustainable development goals (SDGs).
GroMoPo: A Groundwater Model Portal for Findable, Accessible, Interoperable, and Reusable (FAIR) modeling
Authors: Zipper Sam , Befus Kevin , Reinecke Robert , Zamrsky Daniel , Gleeson Tom , Ruzzante Sacha , Jordan Kristen , Compare Kyle , Kretschmer Daniel , Cuthbert Mark , Castronova Anthony , Wagener Thorsten , Bierkens Marc
Published: July 2023

N/A (no abstract)
Internet et bien-être au troisième âge
Authors: Martinelli Paolo
Published: July 2023

Cette étude s'intéresse au rôle des technologies de l'information et de la communication (TIC), en particulier internet, pour le bien-être des personnes âgées en Suisse Romande. En explorant les expériences de six utilisateur·ice·s âgé·e·s d'internet, l'étude met en évidence les bénéfices et les risques associés à son utilisation. Les résultats soulignent l'importance de l'accompagnement et de la formation pour favoriser l'utilisation des TIC par les personnes âgées, en prenant en compte leurs besoins et leurs préoccupations spécifiques. Les participant·e·s ont également souligné l'importance de maintenir les contacts humains tout en utilisant internet. Ces résultats suggèrent que les TIC peuvent être une ressource précieuse pour le bien-être des personnes âgées, mais nécessitent une approche adaptée à leur style d'usage et à leurs besoins individuels.
An fMRI Dataset on Social Reward Processing and Decision Making in Younger and Older Adults
Authors: Smith David Victor , Ludwig Rita M. , Dennison Jeffrey B , Reeck Crystal , Fareri Dominic S.
Published: July 2023

Behavioural and neuroimaging research has shown that older adults are less sensitive to financial losses compared to younger adults. Yet relatively less is known about age-related differences in social decisions and social reward processing. As part of a pilot study that was sponsored by the Scientific Research Network on Decision Neuroscience and Aging, we collected behavioural and functional magnetic resonance imaging (fMRI) data from 50 participants (Younger: N = 26, ages 18–34 years; Older: N = 24, ages 63–80 years) who completed three tasks in the scanner: an economic trust game as the investor with three partners (computer, stranger, friend) as the investee; a card-guessing task with monetary gains and losses shared with three partners (computer, stranger, friend); and an ultimatum game as responder to three anonymous proposers (computer, age-similar adults, age-dissimilar adults). We also collected B0 field maps and high-resolution structural images (T1-weighted and T2-weighted images). These data could be reused to answer questions about moment-to-moment variability in fMRI signal, representational similarity between tasks, and brain structure.
Relationship Between Bullying Victimization and Depression Among Middle School Students: Mediating Effect of Hope and Moderating Effect of Parent-Child Relationship
Authors: Jin Wenqi , Lin Tong , Li Beilei
Published: July 2023

AbstractObjective: To examine the mediating effect of hope in the relationship between bullying victimization and depression and the moderating effect of the parent-child relationship on this mediating model among middle school students. Methods: A total of 795 middle school students completed a series of questionnaires including the Bullying Victimization Scale, the Children’s Depression Inventory-Short Version, the Children's Hope Scale, and the Child-Parent Relationship Scale Short Form. Results: (1) Victimization was a significant positive predictor of depression after controlling for the grade, gender, and maternal education; (2) Agency thinking of hope partially mediated the relationship between victimization and depression; (3) Child-parent conflict, rather than child-parent intimacy, served as a moderator between victimization and agency thinking. Specifically, a lower level of child-parent conflict buffered the impact of victimization on agency thinking, and this buffering effect decreased quickly as the level of victimization increased. Conclusions: Efforts to enhance the agency thinking processes of students should be incorporated into school bullying prevention and intervention programs; Attention should be paid to the constructive resolution process of child-parent conflict in the family, so as to help students transfer the relevant experience to the conflict situation with their peers.KeywordsBullying victimization; Depression; Hope; Parent-child relationship
Identificación del paciente con intoxicación por monóxido de carbono en sala de Emergencia. Estudio de caso clínico
Authors: Robalino Díaz Anderson Raúl , Mendez Pilco Héctor Javier , Molina Molina Danilo Eduardo , Borja Cepeda Vanesa Paola
Published: July 2023

El monóxido de carbono es un gas incoloro, inodoro, insípido   producido por la combustión de hidrocarburos, por lo que puede estar en las cercanías de las viviendas y lugares de trabajo pues podemos obtenerlo en cocinas de leña, chimeneas domésticas, motores de combustión. Y sus características permiten al individuo no identificar la presencia de este tóxico y así facilitar su ingreso al organismo. Provocando hipoxia hística y daño directo a la célula por la producción de carboxihemoglobina, pues la afinidad del monóxido de carbono por la hemoglobina es de 200 a 300 veces mayor que para el oxígeno.
Radio Listenership in Kathmandu
Authors: Shrestha Shrijana
Published: July 2023

Radio plays a significant role in the Kathmandu society and that cannot be overlooked. The theories discussed for this study are uses and gratifications and media dependency theory. The data have been presented using frequency tables and charts. From this research work, it was discovered that the maximum number of respondents have gradually declined their interest and reliability on the radio today. The prevalence of web-based mediums has outdone the usage of radio and it has been reflected in this report as well. The goals are to investigate the current situation of radio listenership in Kathmandu, comprehend the evolution of listenership through time, and apprehend the prospects for radio listenership in the future.

This study's findings revealed that the majority of respondents had seen a progressive fall in their interest in and dependability upon radio nowadays. Respondents' expectations for the future of radio in Kathmandu are apparently not very high. The predominance of web-based media has surpassed the use of radio, and this research confirms that. Finally, by the report's conclusion, we can also see how all the data were analyzed and presented, as well as some recommendations that could be used to raise the status of the radio.
Kantowska filozofia transcendentalna. Mariana Massoniusa próba ujęcia krytycyzmu Immanuela Kanta
Authors: Musioł Anna
Published: July 2023

Autorka artykułu odniosła się do założeń rozprawy doktorskiej Mariana Massoniusa, a także uwzględniła założenia jego kilku pomniejszych prac dotyczących sposobu ujęcia Kantowskiego systemu filozofii krytycznej. Poddała analizie problem sądów analitycznych i syntetycznych oraz sądów syntetycznych a priori. Podjęła zagadnienie możliwości istnienia czystej matematyki, problem czasu i przestrzeni, opisała także sposoby ujęcia Kantowskich antynomii oraz teorii poznania rozwijanej w kontekście idealizmu oraz realizmu czasu i przestrzeni. Uwagę skupiła również na problemie umiarkowanego agnostycyzmu w filozofii Massoniusa oraz ujęciu filozofii w perspektywie nauki. Podjęła również wysiłek udzielenia odpowiedzi na fundamentalne pytanie: dlaczego Marian Massonius, podobnie jak w 1865 roku wczesny neokantysta Otto Liebmann, rzucał wyzwanie powrotu do Kanta (Zurück zu Kant!) oraz głosił postulat koniecznego wypracowania krytycznej formuły apriorycznych form umysłu.
Prawa rzeczowe przysługujące obywatelom Ukrainy na tle obowiązujących w Polsce norm kolizyjnych
Authors: Górecki Jacek
Published: July 2023

Mass inflow of Ukrainian citizens into Poland gives rise to many legal issues, including conflict-of-law questions about rights in rem held by such persons both in respect of property left in Ukraine and property brought to Poland. In the context of the prolonged stay of such persons in Poland, one crucial task may be, for example, to establish the law applicable to the disposal of their property brought to Poland under legal acts made in Poland.The Agreement between the Republic of Poland and Ukraine on legal aid and legal relationships in civil and criminal matters, done at Kiev on 24 May 1993, applicable in Polish-Ukrainian relations, devotes several  provisions to those questions.However, the Agreement ignores the question of the law applicable to property law relationships having movable items as their objects. In particular, it does not designate the law applicable to contracts transferring the ownership of movable assets and contracts encumbering such assets with limited rights in rem. The relevant norms in this regard are conflict-of-law rules of the Polish Act of 04 February 2011 — Private International Law, and of the Ukrainian confl ict-of-law Act of 23 June 2005, designating the law applicable to property.Accordingly, as long as movable items are located in Poland, Polish law will apply with regard to the respective property law relationships. This is provided for in Article 41 (1) of the Private International Law Act. However, Polish law will not apply to obligational and property rights having as their object immovable properties located in Ukraine, which is covered by Article 32 of the Agreement of 24 May 1993. In this regard, Ukrainian law is exclusively applicable.Under Article 41 (2) of the Private International Law Act, in the assessment of legal relationships relating to a movable property brought to Poland from Ukraine, one should also consider legal events taking place when the asset in question was still in Ukraine. However, the assessment of legal events having an impact on property law relationships taking place in Poland and relating to movable items brought back to Ukraine will be based on the Ukrainian law.
Pomoc adwokatów Ukraińcom przybywającym do Polski
Authors: Kovalchuk Anastasiia
Published: July 2023

The author aims to present the possibilities of helping Ukrainian citizens from the practical side, as based on author’s own professional experience. To that effect, the paper considers various legal issues faced daily by Ukrainians who came to Poland after the outbreak of the war in Ukraine. The purpose of the article is also to study the changes in Polish legislation that were introduced to simplify the possibility of regulating the legal situation of Ukrainian citizens residing in Poland. The work touches upon the issue of legalizing the stay of Ukrainians on the territory of the Republic of Poland, the care and guardianship of minor children coming from Ukraine, the transfer of economic activity from Ukraine to Poland, as well as the issue of marriage conclusion by Ukrainians in Poland.
Language Teacher Identity and Emotions in a Duoethnographic Narrative: The Perspective of Teacher, Parent, and Teacher Educator
Authors: Rokita-Jaśkow Joanna , Werbińska Dorota
Published: July 2023

Teacher identity building rather than learning teaching in terms of skills and subsystems has recently been acknowledged as a priority in future teacher preparation. Several teacher identity models have been offered, including the 3A Language Teacher Identity Framework (3ALTIF) (Werbińska, 2017a) in which teacher identity comprises affiliation (teachers’ willingness to teach), attachment (teachers’ beliefs related to their teaching) and autonomy (teachers’ agentive, reflective, and resilient powers). With hindsight, it seems that the 3ALTIF, which drew on other identity models available at the time of its conception, does not address the affective side of language teacher identity explicitly enough and therefore can hardly embrace the uniqueness of this profession. That is why we decided to explore the issue of emotions more deeply and conduct a lengthy duoethnographic narrative to consider the 3ALTIF’s ‘missing’ component for the future ‘improvement’ of the 3ALTIF. Duoethnography was chosen as a qualitative research method thanks to its novelty, its suitability for investigating identity issues and the opportunity it provides for us to explain and express ourselves. In our duoethnographic dialogues we focused on our own emotions from three perspectives: former school language teachers, language teachers as parents, and language teacher educators, all of which are the roles we have played. The findings reveal our experience of emotions that once affected us and also suggest that emotions are not only psychological constructs but have social dimensions as well.