bluuebunny/crossref_metadata_2025 huggingface dataset:
Penatalaksanaan Emesis Gravidarum di Yogyakarta
Authors: Kristiana Dita , Listyaningrum Tri Hapsari
Published: November 2021

Terdapat 50%-75% ibu hamil mengalami mual muntah trimester1. Emesis gravidarum terjadi pada 60-80% primigravida. Di Puskesmas Umbulharjo1 jumlah emesis dalam satu bulan tahun 2016, ditemukan 81% dari ibu hamil trimester 1 yang periksa. Tujuan penelitian mengetahui penatalaksanaan ibu hamil dengan emesis gravidarum. Penelitian ini menggunakan desain observasional deskriptif dengan pendekatan studi kasus. Subyek penelitian ibu hamil dengan emesis gravidarum. Teknik pengumpulan data yaitu wawancara, pemeriksaan fisik, observasi, studi dokumentasi. Penelitian dilakukan Juni-September 2018. Analisa data dengan reduksi, penyajian, penarikan kesimpulan. Penatalaksanaan emesis gravidarum KIE faktor penyebab mual-muntah, dampak mual-muntah, cara mengatasi mual-muntah, memberikan vitamin B6 untuk mengurangi mual-muntah bila perlu karena fisiologis.
Efektifitas Penyembuhan Luka Jahitan Episiotomi Dengan Konsumsi Telur Puyuh Rebus
Authors: Ningsih Sari Widya , Nababan Lolli
Published: November 2021

Tujuan Penelitian ini adalah untuk mengetahui pengaruh konsumsi telur puyuh rebus untuk percepatan penyembuhan luka jahitan episiotomi. Penelitian menggunakan data prime dengan sistem reeda scale pada kelompok kontrol dan perlakuan. Hasil analisis univariat dari 15 orang responden yang mengkosumsi telur puyuh rebus sembuh dalam waktuÂ  5 hari sebanyakÂ  11 Orang (73%), Hasil Analisis Bivariat Dari 30 Responden, yang mengkosumsi makanan protein hewani seperti telur puyuh rebus akan mengalami penyembuhan luka perinium lebih cepat (15 orang) dibandingkan yang tidak mengkosumsi telur puyuh. Hasil p â€“value =0,000 yang berarti ada pengaruh kosumsi telur puyuh rebus terhadap penyembuhan luka perineum.Â
NEONATAL HEALTH OUTCOME OF PREGNANT WOMEN WITH DIABETES MELLITUS
Authors: Rachmawati Fijri
Published: November 2021

Excessive fetal weight attracts attention because it increases perinatal and maternal morbidity and mortality. The prevalence of macrosomia worldwide has increased over the past 2 to 3 decades. This study aimed to determine Neonatal Health Outcome of Pregnant Women with Diabetes Mellitus. The design of this study was analytical with a case control approach. Data used to analyze the incidence of macrosomia based on secondary data from 2014-2018. From the research it can be concluded that diabetes mellitus in pregnancy has a significant relationship with the incidence of macrosomia.
Kewirausahaan
Authors: FADILAH UMMUL
Published: November 2021

Didalam berwirausaha ada beberapa aspek yang menentukan berhasil tidaknya suatu usaha yang dijalankan. Diantaranya aspek modal, pengelolan maupun pemasaran. Modal bisa di dapat dari berbagai cara misalnya denhgan modal yang kita punya sendiri ataupun dengan pinjaman. Oleh karena itu sangat dibutuhkan suatu kemitraan atau hubungan sosial yang baik dalam berwirausaha. Karena terkadang dalam berwirausaha kita tidak dapat memulainya sendiri baik karena kekurangan uang, sumber daya, maupun kreatifitas. Oleh karena itu kemitraan sangat dibutuhkan dan merupakan salah satu aspek yang penting dalam berwirausaha. Sedangkan mengenai pengelolaan atau manajemen dan pemasaran akan lebih baik bila kita menguasainya lebih jauh sebagai seorang wirausahawan, karena aspek pengelolaan dan pemasaran merupakan aspek yang memegang peranan penting. Karena itulah penulis menguraikan pembahasan ini dalam bentuk makalah mengenai bagaimana mengelola sendiri usaha yang dijalani atau mendatangi konsumen sendiri.Dalam bab pembahasan, penulis mencoba untuk menguraikan mengenai beberapa jenis modal usaha yang digunakan oleh umum. Menjadi seorang wirausahawan tidaklah mudah. Dibutuhkan banyak skill , modal, dan mamajemen yang baik. Tentunya kiat-kiat keberhasilan wirausaha dari para pakarntya akan sangat membantu bagi mereka yang ingin memulai suatu usaha.
DESAIN DAN STRUKTUR ORGANISASI
Authors: Najjar Nadilah Anisah
Published: November 2021

Pengorganisasian merupakan suatu proses untuk merancang struktur formal, mengelompokkan dan mengatur serta membagi tugas-tugas atau pekerjaan di antara para anggota organisasi agar tujuan organisasi dapat dicapai dengan efisien.Dalam fungsi pengorganisasian, manajer mengalokasikan keseluruhan sumber daya organisasi sesuai dengan rencana yang telah dibuat berdasarkan suatu kerangka kerja organisasi tertentu. Kerangka kerja tersebut dinamakan sebagai desain organisasi.Bentuk spesifik dari kerangka kerja organisasi dinamakan dengan struktur organisasi. Stuktur organisasi pada dasarnya merupakan desain organisasi dimana manajer melakukan alokasi sumber daya organisasi, terutama yang terkait dengan pembagian kerja dan sumber daya yang dimiliki organisasi, serta bagaimana keseluruhan kerja tersebut dapat dikoordinasikan dan dikomunikasikan.
The future of Alpine Run-of-River hydropower production: climate change, environmental flow requirements, and technical production potential
Authors: Wechsler Tobias , Schaefli Bettina , Zappa Massimiliano , Jorde Klaus , Stähli Manfred
Published: November 2021

Past studies on the impacts of climate change (CC) on Alpine hydropower production have focused on high-head accumulation power plants. We provide one of the first comprehensive, simulation-based studies on CC impacts on Alpine Run-of-River (RoR) production, also considering effects of environmental flow requirements and technical increase potential. We simulate future electricity production under three emissions scenarios for 21 Swiss RoR plants with a total production of 5.9 TWh a-1. The simulations show an increase in winter production (4% to 9%) and a decrease in summer production (-2% to -22%), which together lead to an annual decrease of about -2% to -7% by the end of the century. The production loss due to environmental flow requirements is estimated at 3.5% of the annual production; the largest low-elevation RoR power plants show little loss, while small and medium-sized power plants are most affected. The potential for increasing production by optimising the design discharge amounts to 8% of the annual production. The largest increase potential is related to small and medium-sized power plants at high elevations. The key results are: i) there is no linear relationship between CC impacts on streamflow and on RoR production; the impacts depend on the usable streamflow volume, which is influenced by the Flow Duration Curve, environmental flow requirements, and design discharge; ii), the simulated production impacts show a strong correlation (>0.68) with the mean catchment elevation. The plants at the highest elevations even show an increase in annual production of 3% to 23%, due to larger shares of precipitation falling as rain instead of snow. These general results are transferable to RoR production in similar settings in other Alpine locations and should be considered in future assessments. Future work could focus on further technical optimisation potential, considering detailed operational data.
Neurodevelopmental Differences, Pedohebephilia, and Sexual Offending: Findings from Two Online Surveys
Authors: Jahnke Sara , Schmidt Alexander F. , Klöckner Andrea , Hoyer Jürgen
Published: November 2021

The neurodevelopmental theory of pedohebephilia states that sexual interests in children arise from early neurodevelopmental perturbations, as, for example, evidenced by increased non-right-handedness, more childhood head injuries, and reduced intelligence and height. As corroborating evidence largely rests on samples of convicted men, we conducted online surveys among German-speaking (Study 1, N = 199) and English-speaking men (Study 2, N = 632), specifically targeting community members with pedohebephilic or teleiophilic interests. Although we detected theoretically meaningful sexual interest patterns in an embedded viewing time task, we could not detect expected neurodevelopmental differences between teleiophilic and pedohebephilic men in either of the two studies. Strikingly, pedohebephilic men who reported convictions for sexual offences emerged as smaller and less intelligent than pedohebephilic men without convictions in Study 2. While elucidating possible third variable confounds, results have to be interpreted cautiously because of the methodological problems inherent to non-matched case control designs.
Una reflexión sobre las actitudes hacia la Enfermedad de Alzheimer
Authors: Palacios-Espinosa Ximena , Vargas Jiménez Jenny Fernanda , Calle Nassiff María Paula
Published: November 2021

La enfermedad de Alzheimer (EA) se considera como una afección crónica con alta prevalencia a nivel mundial. Su sintomatología, el impacto que genera en el funcionamiento de la persona y los cambios que causa en su red de apoyo social, han llevado a que sea un tema de amplio interés para la investigación. La idea de desarrollar la EA y convivir con ella genera diversas actitudes, es decir la tendencia a asumir una posición en favor o en contra. Este artículo tiene como objetivo reflexionar sobre las actitudes hacia la EA, a partir de los hallazgos obtenidos en una revisión de la literatura publicada entre 2000 y 2020. Se encontraron diversas creencias hacia la EA en relación con su etiología, curso y tratamiento, así como el predominio de sentimientos y emociones negativos hacia ella. Llama la atención las conductas dirigidas a buscar la prevención de esta enfermedad. Se reflexiona sobre la relevancia y la pertinencia de considerar la evaluación de las actitudes en los contextos de salud.
Estado epiléptico en adultos: caracterización de pacientes monitorizados por videoelectroencefalograma
Authors: Gutierrez Baquero Julán Andrés , Duran Ayllon Juan Pablo , Vergara Aguilar Jean Paul , Palacios Sánchez Eduardo , Silva Soler Miguel Arturo , Lee Niño Jonathan
Published: November 2021

Introducción: el estado epiléptico (EE) es una afección potencialmente mortal con una morbilidad significativa en quienes sobreviven a esta entidad. Pacientes y métodos: estudio transversal descriptivo de corte analítico con el objetivo de describir la prevalencia y la relación con variables sociodemográficas, electroencefalográficas, imagenológicas y desenlaces clínicos en los pacientes que fueron monitorizados por videoelectroencefalograma (VEEG), en el Hospital de San José de Bogotá, Colombia, entre agosto 2017 y agosto 2019. Resultados: de los 135 pacientes monitorizados por VEEG, 27,47% cumplieron con los criterios para EE.  La edad promedio fue 48 (DE: 19,56) años, 54,05% (n=20) de sexo masculino y 75,67% (n=28) sin antecedentes de epilepsia. Predominaron las manifestaciones motoras (70,27%, n=26), en 59,46% en el puntaje STESS fue desfavorable, 64,86% (n=24) requirió inducción a coma y monitorización en la unidad de cuidados intensivos (UCI) y 37,84 % (n=14) fallecieron durante su estancia intrahospitalaria. Se encontró una relación entre EE, requerimiento de UCI y muerte intrahospitalaria. Conclusiones: la prevalencia del EE en pacientes monitorizados por VEEG fue cercana a 28%, lo que sugiere una relación entre EE, requerimiento de UCI y muerte intrahospitalaria.
Leonardo da Vinci y la Neurociencia
Authors: Palacios Sánchez Leonardo , Charry-Sánchez Jesús David , Niño-Calvera Juan David
Published: November 2021

Leonardo da Vinci (1452-1529) fue un reconocido personaje quien hizo grandes aportes a la ciencia y el arte. Demostró un gran interés por la anatomía y fisiología en su paso por el taller de Andrea del Verrocchio el cual se iría incrementando con el tiempo hasta realizar sus propias autopsias y descripciones. Gracias a sus prodigiosas manos, realizó múltiples procedimientos en cadáveres humanos y animales muertos, junto con algunos experimentos que alimentaban su interés por la fisiología. Sus primeros dibujos fueron del cráneo y del encéfalo. Propuso estudiarlo de afuera hacia adentro, por capas. Esquematizó e incluso replicó algunas estructuras, que en aquella época tenían un papel fundamental sobre el entendimiento del cuerpo humano. Con relación al encéfalo, describió el bulbo olfatorio y el recorrido de algunas ramas de los pares craneales. Demostró especial interés en detallar los ventrículos cerebrales debido a la influencia de las teorías propuestas por sus antecesores que integró con sus descubrimientos para explicar las funciones que se les atribuían en la época. Además, fue pionero en neurofisiología con sus experimentos de la médula espinal en ranas. Realizó un trabajo extenso en anatomía y fisiología, dejando grandes aportes en estos campos que desafortunadamente no fueron publicados. Hubo de pasar cerca de tres siglos para que fueran debidamente interpretados.
Dr. Jorge Arana Carvalho
Authors: Arismendy Rodriguez Jeyson Leonardo
Published: November 2021

Los estudios de medicina los inició en 1967 en la facultad de medicina de la Universidad Nacional y obtuvo el grado como médico cirujano en 1974, habiendo hecho previamente el llamado rural en los hospitales San José de Sogamoso y San Vicente de Génova Quindío.

Conocí a Jorge hacia el año de 1976, cuando ingresó a nuestro servicio de neurocirugía para iniciar su entrenamiento y al finalizarlo viajó en 1980 a Gainesville (Florida) al servicio de neurocirugía del profesor Rhoton y luego fue a Alemania al servicio del profesor Herrman, permaneciendo allá durante 1981 y 1982, profundizando en la cirugía de columna y en microcirugía.
Perceived impact of COVID-19 on sexual health and access to sexual health services among university students in Canada
Authors: Wood Jessica , Quinn-Nilas Christopher , McKay Alexander , Wentland Jocelyn
Published: November 2021

We examined the perceived impact of the COVID-19 pandemic on sexual health, sexual behaviour, well-being, and access to sexual health services among university students in Canada. Between December 2020 and January 2021, 1504 university students across Canada completed an online survey focused on overall sexual health, well-being, solitary sexual behaviours, partnered sexual interactions, and access to sexual health services. The survey was designed by the Sex Information & Education Council of Canada and administered by the Leger polling company. Reported levels of overall sexual health were high. Cisgender women reported significantly greater scores of COVID-19—related stress compared to cisgender men; LGBQ+ students had higher levels of stress compared to heterosexual participants. Overall, solitary sexual behaviours (i.e., masturbation, porn use, vibrator use) remained unchanged or were perceived to increase compared to the time before the pandemic. Cisgender men reported higher scores (i.e., greater perceived increases) on masturbation and porn use than cisgender women. Frequency of sex with casual partners was perceived as similar or lower than what was usual before the pandemic, and most participants did not engage in sex where the close personal contact put them or their partner at risk for COVID-19. Declines in access were reported for all sexual health care services surveyed, with cisgender women and students of colour more likely to report decreased access to services. Results highlight the need for targeted public health messaging regarding sexual behaviour, investment in sexual health services, and supports tailored to the needs of women, LGBTQ+ individuals, and people of colour.
Dynamic Test Methods
Authors: Kompatscher M.
Published: November 2021

In dynamic hardness tests, the test force is applied to the defined indenter in an accelerated way (with a high application rate). Dynamic test methods relate hardness to the elastic response of a material, whereas the classical static indentation tests determine hardness in terms of plastic behavior. This chapter describes the most important and widespread dynamic hardness testing methods. These tests fall into two categories: methods in which the deformation is measured and methods in which the energy is measured. Methods that measure deformation include the Poldi hammer method, the shearing force method, the Baumann hammer method, and the Dynatest method. Methods that measure energy include the Shore method, the Leeb method, and the Nitronic method. The chapter concludes with a discussion of applications of dynamic hardness testing.
CALCULATION OF INDICATORS OF ENVIRONMENTAL IMPACT OF MINING ENTERPRISES ON THE STATE OF THE NATURAL ENVIRONMENT
Authors:   Donetsk National Technical University, Bohomaz Olha , Zavialova Оlena ,   Donetsk National Technical University
Published: November 2021

Purpose. The aim of the work is to quantify the indicators of the environmental impact of mining enterprises on the state of the natural environment during the operation of a mining enterprise and after its liquidation. Method. The paper uses a computational and analytical research method. Results. Based on the calculations performed, it was established that the specific assessment of the environmental impact on the biosphere components of the Mining Enterprise PJSC "MM "Pokrovskoe" for the entire estimated period of the mine's existence: lithosphere – 0.071; hydrosphere – 0.02; atmosphere – 0.77; biota – 0.009; physical fields – 0.13. After the liquidation of the mine, due to the termination of coal mining operations from methane-free coal seams, the absence of emergency gas emissions, as well as a decrease in noise and heat pollution, the specific impact on the atmosphere (0) and physical fields (0.0004) is significantly reduced, but at the same time, the impact on the hydrosphere (0.26) and lithosphere (0.72) significantly increases, which is associated with changes in the hydrological regime of water and the deterioration of mine discharges of water quality in the hydrographic network due to pumping mine effluents to the daytime surface, with the dry method closing the mine, and waterlogging of the territory with a wet and combined method of closing the mine. The indicator of specific impact on the biota (0.009) does not change. Scientific novelty. A methodology for calculating indicators of the environmental impact of mining enterprises on the state of the natural environment is proposed. Practical significance. The obtained indicators of environmental impact on the components of the biosphere can serve as a basis for developing measures to reduce the negative manifestations of mining enterprises on the state of the natural environment. Key words environmental risk, mining enterprise, biosphere components, environmental impact.
In Search of a Histopathological Pattern of Immune-Mediated Gastritis from Nivolumab Therapy: A Case Report with Literature Review
Authors: Fernández-Gordón Sánchez Flor M , Fernández-Gordón Sánchez Flor M , Gomez Dominguez Elena , Garfia Castillo Cristina , Arroyo Andres Jorge , Robles Diaz Luis , Rodriguez Gil Yolanda
Published: November 2021

Immunotherapy with checkpoint inhibitors is associated with termed inflammatory and immune-related side effects (irAE). Upper gastrointestinal symptoms are infrequent and appear mainly in patients on combination therapy with two checkpoint inhibitor drugs. We present the case of a patient with IIIB stage cutaneous melanoma treated with Nivolumab in monotherapy who developed an immune-mediated gastritis. Histopathologically, due to the paucity of published cases, no specific pattern of Nivolumab-immune-mediated gastritis has been described. We have reviewed the literature and compared the histopathology of the cases available in the literature.
Surgical Results of Lumbar Canal Recalibration by Modified Senegas Technique
Authors: De La Paz Norbery
Published: November 2021

The aim of recalibration of the lumbar canal using the Senegas technique guarantees stability and preserves movement, with a considerable reduction in surgical risk and faster incorporation into daily life. Objective: To evaluate the surgical results of recalibration of the lumbar canal using the modified Senegas technique. Materials and Methods: An ambispective and cross-sectional descriptive observational study was carried out at the Institute of Neurology and Neurosurgery between January 2011 and December 2019 that were evaluated 6 and 12 months after having been operated. Results: 70.7% of the patients manifested chronic low back pain, and dysesthesia was found in 39.8%. There were 15.8% complications. The clinical evolution according to the Lumbar and Lower Limb Verbal Numerical Scale and the functional one according to the Oswestry Disability Index was better at 6 and 12 months after the intervention compared to the preoperative period. The result was considered good at 82.7% and 89.4%, respectively, at 6 and 12 months. Conclusions: The clinical and functional evolution of the operated patients is significantly better at 6 and 12 months concerning the preoperative one. At both 6 and 12 months, surgical results are good in the vast majority of patients.
POTENTIAL RISKS IN MODERN ANTIBIOTIC THERAPY
Authors: Drogovoz S. M. , Kalko К.O. , Toziuk O. Yu. , Hainiuk M. B. , Taran A. V.
Published: November 2021

Knowledge of the safety profile of antibacterial drugs is important for rational pharmacotherapy with antibiotics. The purpose of this information is to help the doctor, pharmacist and patient to (quickly) "navigate" in the safety of antibiotics to implement one of the basic principles of pharmacotherapy "Do no harm!". The aim of the study. Analysis of possible potential risks in modern antibiotic therapy. Materials and methods. Analysis of data from the scientific literature on the side effects of antibiotics. Results. Most antibiotics have a wide spectrum of antimicrobial action, much less of them have a narrow spectrum of activity, but all of them have side effects (SE). In particular, the neurotoxicity of penicillins and fluoroquinolones is a consequence of their antagonism with GABA. The latter mechanism is also responsible for the neurotoxicity of carbapenens, monobactams and cephalosporins. Cardiotoxicity and hematotoxicity of benzylpenicillins are the result of inhibition of tissue respiration and the process of converting fibrinogen to fibrin, which causes bleeding. The hematotoxicity of carbopenicillins, monobactams and cephalosporins is associated with the inhibition of the conversion of vicasol (vit. K) into its active form, as well as the obstruction of its synthesis due to the suppression of normal intestinal microflora (the main producer of endogenous vit. K). The nephrotoxicity of aminoglycosides and vancomycin is associated with the accumulation of these drugs in the cells of the proximal renal tubules and impaired enzyme activity (Na+-, K+-, ATP; respiratory, etc.), which leads to interstitial nephritis. Ototoxicity of antibiotics is observed when they are used over the age of 60 – a factor that predisposes to ototoxicity. Conclusions. In order to conduct effective antibiotic therapy, it is very important to take into account the side effects that are characteristic of certain groups of antibiotics and each is representatively individual.
Pharmaceuticals in Southeast Asia: reality and future prospects
Authors: Akimova Varvara
Published: November 2021

The article is dedicated to the analysis of the pharmaceutical industry, one of the most actively developing sectors of the world economy, in the region of "new development" — Southeast Asia. It was found that at the present in the countries located in the region under consideration, there is a gradual shift away from the purely production stages of drug manufacturing in favour of an intersectoral pharmaceutical complex. There is a functional diversification of the pharmaceutical industry with deepening corporate specialization. However, a pronounced specialization in the production of a particular type of product is characteristic only for countries with high and medium levels of development of the pharmaceutical industry — Singapore, Malaysia and Indonesia. There is a gradual transformation of the territorial structure from monocentric — with a growth pole in the form of Singapore, to polycentric due to the growing contribution of Malaysia, Thailand and Indonesia. A distinctive feature of the pharmaceutical industry in Southeast Asia is the enclave type of development of its territorial structure at the country level. A significant part of production facilities and research laboratories is concentrated in one (capital), less often in two centres (the case of Indonesia — West and East Java and Vietnam with industrial cores in Hanoi and Ho Chi Minh City).
FACTORES ASOCIADOS A LOS ESTILOS DE VIDA EN LOS ESTUDIANTES UNIVERSITARIOS. UNA APLICACIÓN DEL INSTRUMENTO FANTÁSTICO
Authors: Montenegro Goenaga Alis Neris , Ruíz Marín Alfonso
Published: November 2021

Objetivo: Determinar los factores asociados a los estilos de vida de estudiantes de la Universidad del Atlántico. Materiales y Métodos: Se realizó un estudio de corte transversal, en la Universidad del Atlántico, se seleccionaron aleatoriamente 380 estudiantes. Se utilizó el instrumento FANTÁSTICO para determinar los factores que asocian estos estudiantes a los diferentes estilos de vida.  El procesamiento y análisis de los datos se realizó con el software estadístico SPSS. Resultados: Se determinaron características sociodemográficas de los estudiantes. En términos de edad, la media fue de 21,3 años y la media del promedio de notas fue de 3,7; se determinó que los estudiantes en un 73,6% pasan más de 2 horas en el computador, al igual que, en el celular; en los hábitos por rango de edad, en los dominios del cuestionario el fantástico resultaron ser estadísticamente significativas. Respecto a los estilos de vida adecuada e inadecuada, las variables de nutrición, actividad física, tipo de personalidad, introspección, sueño y manejo del estrés, alcohol y otras drogas, resultaron ser estadísticamente significativas. Conclusión: Se determinaron los factores que asocian los estudiantes a los diferentes estilos de vida, las características sociodemográficas y académicas de los estudiantes y se infirieron sus comportamientos a través de los hábitos y las costumbres relacionados con la salud, los estilos de vida y el sedentarismo.
Wilhelm Georg Berger’s Music: Elements of compositional style and instrumental techniques necessary for the public performance
Authors:   Brașov Philharmonic, Transilvania University of Brașov, VARVARICHI Leona , NAUNCEF Alina-Maria ,   Transilvania University of Brașov
Published: November 2021

The present paper approaches a part of the vast creation of a musician of certain value, to whom generations of players have a moral duty. The analyses of Wilhelm Berger’s sonatas for viola come to the help of those set on the road of an interpretative effort projected over these opuses. The purpose of this brief research is to investigate several elements of the metamorphosis of the compositional phenomenon in two of Wilhelm Georg Berger’s works: The Sonata for viola and piano op. 3 (1957) and the Sonata for solo viola op. 35 (1968). The particular way of processing the musical material originates from his analytical and philosophical thinking. Berger’s compositional technique preserves the principles of the sonata genre structure in both works, using a totally different musical language in the Sonata Solo, 11 years later. The ethos of the music changes, therefore a series of instrumental techniques corresponding to musical expressions encountered in the text are proposed for a better understanding and performing Berger’s music.
A Stylistic approach to Mihail Jora's pianistics as reflected in the Cycle Five Songs for Voice and Piano on Poems by Octavian Goga, op. 11
Authors:   National University of Music Bucharest,, DOBIA Andreea
Published: November 2021

Jora’s songs are musical architectural miniatures with a significant dramatic component, carefully wrought with regard to prosody and diction. The performer’s stage presence, gestures attitude next to sound and word are constitutive parts of the musical discourse. The philosophical state that the composer projects in his sonorities is specific to the early 20th century. His interest in philosophical concepts and his views on life, the attention to love, nature and symbolism are found in the selection of the lyrics alongside compositional means, prosody, the art of singing and that of piano playing.
Compositional premises in approaching Suor Angelica role in the homonymous work of Puccini
Authors:   Transilvania University of Brașov,, DUCA Paula , PEPELEA Roxana ,   Transilvania University of Brașov,
Published: November 2021

This article proposes to summarise some of the defining compositional and interpretive elements on which approaching Suor Angelica role from the lyrical artist perspective is based. Suor Angelica role is a vocal challenge of a complex type, with an extreme difficulty that is often underestimated, requiring a diversity of interpretive resources at the same time. Through this article, we aim to discover the elements on which the interpretation via compositional conception is based, on the level of the musical – vocal and orchestral – discourse of the text and the libretto. The building of the main features of Suor Angelica character is pursued via a dual approach. The article correlates the assessment of the solo parts – like ‘Senza mamma, o bimbo, tu sei morto’ – by following the music and scenic interaction of the main character with the other characters in the homonymous opera.
Technical strategies for improving the accompanying skills in the piano-voice duo
Authors:   Transilvania University of Brașov,, FRĂȚILĂ Lioara
Published: November 2021

This guide of vocal accompanying studies in depth, the nature of a good collaborative relationship between the pianist and the vocalist, it is written from the viewpoint of the pianist, and deals with technical, practical and inspirational elements of accompanying singers. The importance of working with languages and knowledge of the text is emphasized. Much of the vocal repertoire presents technical hurdles that need generous hours of practice. But a good technique also opens up a great deal more in terms of tone production and control. A sensitive touch will allow for a range of flexibility in following the vocalist, and for matching tone quality.
Elements of musical legacy reflected in Eugène Ysaÿe’s solo violin works
Authors:   Transilvania University of Brașov, ROPOTAN Radu Mihai
Published: November 2021

Without question the world we are living in is constantly changing hence experiencing new perspectives. Every now and then there is a personality that inspires others and brings forth new ideals and ideas that capture innovative inherent expressions. One of those musical personalities was Eugène Ysaÿe. Ysaÿe has managed to encompass and bring new pedagogical-interpretative violinistic ideals that merge together the history of performance on the violin together with the music history as a whole. The op. 27 of Eugène Ysaÿe represents his most notable composition that bears a distinct mark of this fascinating violinist and musician.
Numerological symbols in Schoenberg's creation
Authors:   Transilvania University of Brașov, RUCSANDA Mădălina , BELIBOU Alexandra ,   Transilvania University of Brașov
Published: November 2021

Expressionism in music was the movement that brought the contrast to previous eras promoting a tense music, exacerbation of means of expression and destruction of tonal balance. The works that belong to this innovative artistic movement involve diverse interpretations, because they capture the general tense atmosphere, from an aestheticphilosophical perspective, highlighting some text-sonority correspondences and the expressiveness of the elements of musical language. Over time, various connections have been made between music and mathematics, proving that mathematics can give a solid, deep foundation to music, without having a major impact on the rendering of feelings. This research presents some aspects of how numerology influenced and marked the creation of the expressionist composer Arnold Schoenberg. By using the symbolism of numbers, we can better understand the way the composer thought and created his music, strongly marked by the dissolution of tonality, the twelve-tone technique, and the transition from belcanto to "Sprechgesang" and “Sprechmelodie”.
PERDAGANGAN PEREMPUAN DAN ANAK SEBAGAI KEJAHATAN TRANSNASIONAL
Authors: Prasetia Yudhya
Published: November 2021

Organized crime in the transnational trafficking of women and children is a serious and farreaching crime and can even be classified as crimes against humanity as stated in the Rome Statute (1998) which regulates the permanent international criminal court. The objective of the provisions in protocol II is the criminal organization behind the trafficking of women and children, namely by punishing the perpetrators and protecting their victims, namely women and children. In the Palermo Convention2000) it is emphasized that the main objective is to enhance and strengthen cooperation between states parties in preventing and eradicating the five types of crimes which are the jurisdiction of the convention. This paper is the result of a research useing normative juridical approach by reviewing, and examining secondary data in the form of legislation, legal principles, and cases relating to the problem regarding to the trafficking of women and children.
Ways to Success in Education: Students’ Behavioral Strategies in Regional Universities of Russia
Authors: Ambarova P. A. , Zborovsky G. E.
Published: November 2021

The article discusses the behavioral strategies of students of regional Russian universities, focused on achieving educational success. The situation of uncertainty in modern higher education is shown as a social context that determines the variability of students’ behavioral strategies. A factor that has a significant impact on the phenomenon under study is the change in the views of the main educational communities (teachers and students) about educational success: the expansion of the range of its components, differentiation among different groups of students, orientation to non-educational benefits and values that can be obtained by university graduates in the future at the expense of educational capital. Based on the data of an empirical study conducted in the universities of the Sverdlovsk region in 2019-2021, the characteristic of behavioral strategies for achieving educational success implemented by students of Ural universities is given. It is noted that strategies for achieving success in education begin to be formed in the pre-university period, as part of the transition from school to university. It is concluded that during the university period, in response to new goals and learning difficulties, different groups of students develop four types of behavioral strategies – traditional, innovative, imitation, and «withdrawal» strategies.
Effects of SARS-CoV-2 on the endocrine system
Authors:   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Petunina N.A. ,   L.A. Vorokhobov City Clinical Hospital No. 67, Moscow, Russian Federation, Shkoda A.S. ,   L.A. Vorokhobov City Clinical Hospital No. 67, Moscow, Russian Fede, Telnova M.E. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Goncharova E.V. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kuzina I.A. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federatio, El-Taravi Y.А. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Martirosian N.S. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   L.A. Vorokhobov City Clinical Hospital No. 67, Moscow, Russian Federation
Published: November 2021

SARS-CoV-2 rapidly spread worldwide and resulted in an unprecedented pandemic. Considering the novelty of this disease, its potential effects on the endocrine system remain elusive. This virus is known to utilize the extracellular domain of angiotensin-converting enzyme (ACE) and transmembrane protein TMPRSS2. Broad expression of ACE-2 and TMPRSS2 is a potential cause of extrapulmonary manifestations of SARSCoV- 2, including endocrine ones. The most common presentations are direct or indirect damage of the endocrine part of the pancreas, hypothalamicpituitary- adrenal and hypothalamic-pituitary-thyroid axes, and possible long-term effects on the reproductive system. It was demonstrated that obesity and diabetes increase the risk of severe course and death in COVID-19. Similarly, patients with transitory hyperglycemia have a higher risk of severe disease course. Primary and secondary adrenal insufficiency of various origins potentially accounts for severity. The most common thyroid complications of the COVID-19 infection are euthyroid sick syndrome and transient destructive thyroiditis, including subacute thyroiditis. KEYWORDS: SARS-CoV-2, COVID-19, endocrinopathies, diabetes, adrenal insufficiency. FOR CITATION: Petunina N.A., Shkoda A.S., Telnova M.E. et al. Effects of SARS-CoV-2 on the endocrine system. Russian Medical Inquiry. 2021;5(9):575–578 (in Russ.). DOI: 10.32364/2587-6821-2021-5-9-575-578.
New powerful treatment approach to type 2 diabetes
Authors:   A.S. Loginov Moscow Clinical Research Center, Moscow, Russian Federation, Mkrtumyan A.M. , Sviridova M.I. ,   N.E. Bauman City Clinical Hospital No. 29, Moscow, Russian Federation
Published: November 2021

The prevalence of type 2 diabetes (T2D) is very high and grows dangerously, being the most common cause of death. Severe vascular and neurological complications, which result in early disability and high mortality, and reduction in life expectancy and the quality of life, account for the medical and social relevance of T2D. T2D is characterized by progressive dysfunction of pancreatic β-cells in the development of insulin resistance. This paper addresses the mechanisms of action of glucose-lowering medications, i.e., pioglitazone belonging to a group of peroxisome proliferator-activated receptor (PPARγ) agonists, and alogliptin belonging to a group of dipeptidyl peptidase 4 (DPP-4) inhibitors. Pioglitazone increases insulin sensitivity via enhancing the expression of numerous genes encoding proteins that modulate glucose and lipid metabolism. Alogliptin improves the glucose-dependent activity of β-cells and inhibits the increased secretion of glucagon. Alogliptin is characterized by low risks of hypoglycemia and cardiovascular safety. Pioglitazone-alogliptin fixed-dose combination is helpful to control T2D effectively and safely since this combination affects 10 out of 11 pathophysiological defects resulting in T2D. KEYWORDS: type 2 diabetes, insulin resistance, β-cells, dipeptidyl peptidase 4 inhibitor, thiazolidinediones, gliptin. FOR CITATION: Mkrtumyan A.M., Sviridova M.I. New powerful treatment approach to type 2 diabetes. Russian Medical Inquiry. 2021;5(9):592–597 (in Russ.). DOI: 10.32364/2587-6821-2021-5-9-592-597.
Unsolved diagnostic issues of hypophosphatasia: Expert Council
Authors:   Research Center for Medical Genetics, Moscow, Russian Federation, Zakharova E.Yu. , Varlamova T.V. ,   Petrozavodsk State Univerity, Petrozavodsk, Russian Federation, Voronin S.V. ,   Regional Clinical Center of Specialized Medical Care, Vladivostok, Russian Federation, Vlasenko N.Yu. ,   Omsk State Medical University, Omsk, Russian Federation, Kochegurova E.M. ,   Tver State Medical University, Tver, Russian Federation,   E.M. Bakunina Regional Clinical Perinatal Center, Tver, Russian Federation, Mambetova A.M. ,   Kh.M. Berbekov Kabardian-Balkar State University, Nalchik, Russian Federation, Pechatnikova N.L. ,   Morozov Children’s City Clinical Hospital, Moscow Russian Federation, Sosnina I.B. ,   Consultative Diagnostic Center for Children, St. Petersburg, Russian Federation, Udalova O.V. ,   Privolzhsk Research Medical University, Nizhniy Novgorod, Russian Federation, Khramova E.B. ,   Tyumen State Medical University, Tyumen, Russian Federation
Published: November 2021

Hypophosphatasia (HPP) is a rare hereditary metabolic disease resulting from the loss-of-function mutation in the ALPL gene encoding tissue-nonspecific alkaline phosphatase (ALP). Clinical presentations are polymorphic and manifest themselves differently depending on the age of disease onset and severity. The occurrence of mild disease, including adult HPP, is challenging to assess due to the high heterogeneity of clinical signs and a lower diagnosis rate. Doctors’ awareness of HPP is the fundamental factor affecting its detection rate. This paper reviews the conclusions of the Expert Council on HPP diagnosis and potentialities to improve diagnosis. Ten experts from various Russian regions participated in panel sessions. Each member shared the experience and established practice on the diagnosis of orphan diseases in his/her region and gave suggestions to optimize the diagnostic approach to HPP. The result was the development of a management algorithm and routing of patients from identifying symptoms to decision making on prescribing enzyme-replacement therapy and subsequent follow-up at every level of medical care . KEYWORDS: hypophosphatasia, alkaline phosphatase, orphan diseases, ALPL, enzyme-replacement therapy, routing. FOR CITATION: Zakharova E.Yu., Varlamova T.V., Voronin S.V. et al. Unsolved diagnostic issues of hypophosphatasia: Expert Council. Russian Medical Inquiry. 2021;5(9):605–614 (in Russ.). DOI: 10.32364/2587-6821-2021-5-9-605-614.
Infodemia: ways to recognize and counter information influences during a pandemic
Authors:   Ukrainian Science Methodological Center of Applied Psychology and Social Work of NAES of Ukraine, Hnida Tetiana
Published: November 2021

Since the beginning of the pandemic, humanity has faced an additional threat, namely the spread of unnecessary, unreliable and harmful information, which is called infodemia. It has become one of the greatest challenges of our time therefore the heads of state, world organizations and owners of social media have stepped up to fight it. In our opinion, pedagogical workers, in particular employees of the psychological service of the education system, should join the educational and preventive work. Every user of social networks becomes a newsmaker with only an account and access to the Internet. And because students are active users of social media, the share of their participation in the dissemination and creation of false information is significant. This publication proposes a system of starting practical psychologists and social educators of educational institutions in the relevant refresher courses, which will allow them to conduct quality practical work with students and their parents. The content of training should take into account the components of the nutrient medium for information viruses, the fight against pandemic fakes, the system of forming sensational news, the features of hate speech, the formation of news literacy and others. It is also necessary to train specialists, and later each student, to recognize false, partially reliable and manipulative information. Since the main spreader of information viruses is humans, training should apply to everyone. Keywords. Infodemia, pandemic, information viruses, fake news, fake account, stress, fear, panic, manipulation, isolation, social media, marking information, factcheking, media education, course for practice psychologists and social pedagogues, practice lessons with students, information immunity, clickbait, discrimination, newsmaker, critical thinking, protection from hidden influences, media responsibility, media culture
WORK OF THE PRACTICAL PSYCHOLOGIST FOR PREVENTING VIOLENCE BETWEEN STUDENTS IN QUARANTINE PERIOD
Authors:   Ukrainian Science Methodological Center of Applied Psychology and Social Work of NAES of Ukraine, Sosnovenko Nataliia
Published: November 2021

The problem of violence against children has always existed and will probably exist. Today, its consequences, such as the death of children from starvation, during bombing and and shooting, murder during domestic quarrel are widespread. There are also forms of violence, such as sale of children, lebworks, economic exploitation, prostitution, neglect of needs and interests etc. Closure of educational institutions, distance learning through COVID-19 has radically changed the form of psychological support for students. Forced isolation has exacerbated the already difficult problem of violence. The purpose of the study is to substantiate the problem of prevention of violence among students during quarantine; to determine the algorithm of work of a practical psychologist on prevention of violence among students during the quarantine period; propose measures to prevent domestic violence. A study was conducted during November 2020 by conducting group focus interviews with teachers of educational institutions on the consequences of the COVID-19 pandemic. The aim was to determine the impact of the pandemic and quarantine measures on the implementation of the educational process in general and its participants in particular. The poll was anonymous. The Coverage of respondents – 3209 people. The level is all-Ukrainian. The algorithm of actions of pedagogical workers in case of revealing signs or facts that may indicate the commission of violence against a child at work and the algorithm of a practical psychologist for the prevention of violence among students during quarantine are determined. Activities with teachers, students and parents on the prevention of domestic violence are proposed. Keywords. abuse, violence prevention, quarantine, students, practical psychologists, psychological service
УПРАВЛІННЯ БЕЗПЕКОЮ ТУРИСТИЧНОЇ ГАЛУЗІ В УМОВАХ ПАНДЕМІЇ СOVID-19
Authors: Живко Зінаїда , Лелюк Наталія , Родченко Світлана
Published: November 2021

Стаття присвячена проблемам управління безпекою туристичної сфери. Туризм – складна соціально-економічна система, яка здійснює комплексний вплив на розвиток економіки: розвиток туристичної сфери сприяє розвитку туристичних зон, збільшенню кількості подорожей, підвищенню якості життя людей, соціально-культурному розвитку населення, збільшенню надходжень до місцевих бюджетів. Встановлено, що поняття «безпека туризму» включає в себе особисту безпеку туриста, безпеку здійснення підприємницької діяльності у туристичній сфері, безпеку держави, в якій надаються туристичні послуги. Проведено аналіз впливу пандемії СOVID-19 на розвиток туристичної сфери. Встановлено, що пандемія стала причиною скорочення обсягів наданих туристичних послуг та перерозподілу надходжень від надання туристичних послуг на користь вітчизняного туриста. Розроблено заходи управління безпекою туристичної галузі в умовах пандемії.
Approximation of the Separation Boundary in the Water-Hydrotrope-Oil Ternary Systems
Authors:   Gubkin Russian State University of Oil and Gas, Kuchierskaya A. A. , Diyakovskaya A. V. ,   Gubkin Russian State University of Oil and Gas, Sayfutdinova A. R. ,   Gubkin Russian State University of Oil and Gas, Semenov A. P. ,   Gubkin Russian State University of Oil and Gas, Novikov A. A. ,   Gubkin Russian State University of Oil and Gas
Published: November 2021

In this work, we studied the ternary systems water – 2-butoxyethanol – toluene, water – methanol – chloroform and water – methanol – dichloromethane. The separation boundary was experimentally located and approximated by various functions. The main reasons are revealed that prevent a satisfactory approximation of the separation boundaries by empirical functions with a small number of optimized parameters. It is found that the approximation of the separation boundaries in ternary systems can be carried out by polynomial and piecewise smooth functions with an error comparable to the uncertainty of the measurement.