bluuebunny/crossref_metadata_2025 huggingface dataset:
Why Do Experts and Amateurs Diverge in Their Tastings? A Pragmatic Analysis of Perception
Authors: Teil Geneviève
Published: November 2023

This pragmatic study addresses the question of the plural realities that emerge from perception, based on an empirical analysis of the tasting activity of wine amateurs and olfactory experts. Though they share the same requirement of rooting taste in the product under scrutiny, they also significantly differ regarding the constraints with which their tasting results have to comply: repeatability for experts’ tasting results, and activity contiunuation for amateurs. Both therefore foster the emergence of two contrasting realities: a stabilized one for experts; an ‘un-stabilized’ one for amateurs. Both happen to fit with the ‘fiction’ and the ‘reference’ modes of existence of Latour’s inventory, which extends and relaunches the analysis of the coexistence of activities initiated by the works on ‘boundary objects’ some decades ago. Finally, the notion of taste is reinterpreted as a translation operator between tasting realities.
Novel voxelwise residual analysis of [11C]raclopride PET data improves detection of low-amplitude dopamine release
Authors: Bevington Connor WJ , Hanania Jordan U , Ferraresso Giovanni , Cheng Ju-Chieh (Kevin) , Pavel Alexandra , Su Dongning , Stoessl A Jon , Sossi Vesna
Published: November 2023

Existing methods for voxelwise transient dopamine (DA) release detection rely on explicit kinetic modeling of the [11C]raclopride PET time activity curve, which at the voxel level is typically confounded by noise, leading to poor performance for detection of low-amplitude DA release-induced signals. Here we present a novel data-driven, task-informed method—referred to as Residual Space Detection (RSD)—that transforms PET time activity curves to a residual space where DA release-induced perturbations can be isolated and processed. Using simulations, we demonstrate that this method significantly increases detection performance compared to existing kinetic model-based methods for low-magnitude DA release (simulated +100% peak increase in basal DA concentration). In addition, results from nine healthy controls injected with a single bolus of [11C]raclopride performing a finger tapping motor task are shown as proof-of-concept. The ability to detect relatively low magnitudes of dopamine release in the human brain using a single bolus injection, while achieving higher statistical power than previous methods, may additionally enable more complex analyses of neurotransmitter systems. Moreover, RSD is readily generalizable to multiple tasks performed during a single PET scan, further extending the capabilities of task-based single-bolus protocols.
Incidence of Achilles tendon rupture: 25-year regional analysis with a focus on bilateral ruptures
Authors: Čretnik Andrej , Košir Roman
Published: November 2023

Objective

We aimed to fill the research gap regarding the incidence of Achilles tendon rupture (ATR), which is reportedly increasing, as there is a lack of data on the incidence of ATR and no data on bilateral ruptures in our region.

Methods

We determined the incidence of complete ATR among 273,485 people during 1991 to 2015.

Results

In the study period, 524 patients (486 [92.75%] men and 38 [7.25%] women, average age 39.03±10.86 [range 20–83] years, = sex ratio 12.8:1) were treated for ATR in our study area. The average incidence was 7.77 per 100,000 person-years, with an increasing trend until 2008 and peak incidence of 11.33 per 100,000 person-years. Most injuries (67.04%) occurred while performing sports activities. In total, 7 (1.34%) patients (six men [1.23%] and one woman [2.63%]) experienced ruptures on both sides, an average of 5.1 years apart; the average age at the second rupture was 57.71±16.69 (range 39–83) years, with a calculated incidence for bilateral ATR of 0.1 per 100,000 person-years.

Conclusions

The incidence of complete ATR in our study region increased gradually between 1991 and 2008, after which it declined. Bilateral ATR during that period was a very rare injury.
Governing beyond the project: Refocusing innovation governance in emerging science and technology funding
Authors: Smith Robert DJ , Schäfer Stefan , Bernstein Michael J
Published: November 2023

This article analyses how a recent idiom of innovation governance, ‘responsible innovation’, is enacted in practice, how this shapes innovation processes, and what aspects of innovation are left untouched. Within this idiom, funders typically focus on one point in an innovation system: researchers in projects. However, the more transformational aspirations of responsible innovation are circumscribed by this context. Adopting a mode of critique that assembles, this article considers some alternative approaches to governing the shared trajectories of science, technology, and society. Using the idea of institutional invention to focus innovation governance on four inflection points—agendas, calls, spaces, evaluation—would allow funding organizations and researchers to look ‘beyond the project’, developing new methods to unpack and reflect on assumed purposes of science, technology, and innovation, and to potentially reconfigure the institutions that condition scientific practice.
Outcomes of Anterior Cruciate Ligament Reconstruction With Independently Tensioned Suture Tape Augmentation at 5-Year Follow-up
Authors: Wilson William T. , Kennedy Matthew J. , MacLeod Douglas , Hopper Graeme P. , MacKay Gordon M.
Published: November 2023

Background:

Reconstruction using autograft remains the gold standard surgical treatment for anterior cruciate ligament (ACL) injuries. However, up to 10% to 15% of patients will suffer a graft failure in the future. Cadaveric studies have demonstrated that the addition of suture tape augmentation to ACL autograft constructs can increase graft strength and reduce elongation under cyclical loading.

Purpose/Hypothesis:

This study aimed to investigate the clinical outcomes and rerupture rates after ACL reconstruction (ACLR) with suture tape augmentation. We hypothesized that augmentation with suture tape would lead to lower rerupture rates.

Study Design:

Case series; Level of evidence, 4.

Methods:

Patients undergoing primary ACLR using hamstring or patellar tendon autografts augmented with suture tape between 2015 and 2019 were recruited prospectively. Patients with multiligament injuries or a concomitant lateral extra-articular procedure were excluded. Patients were observed in person for 6 months, and patient-reported outcome measures (PROMs) were collected at 2 and 5 years postoperatively. All patients were contacted, and records were reviewed to determine the incidence of graft failure. PROMs collected were as follows: Knee injury and Osteoarthritis Outcome Score (KOOS), Veterans RAND 12-Item Health Survey (VR-12), Tegner and Marx activity scores, and visual analog scale for pain (VAS).

Results:

A total of 97 patients, with a mean age of 34.7 (±13.4) years, were included (76% men; 52 hamstring and 45 patellar tendon grafts). The mean graft diameter was 8 (±1) mm. There was 1 rerupture (1.1%) out of the 90 patients who were contactable at a mean of 5 years postoperatively. Median KOOS scores at 2 years were as follows: Pain, 94; Symptoms, 86; Activities of Daily Living, 99; Sport and Recreation, 82; and Quality of Life, 81. The postoperative scores were significantly higher than the preoperative scores ( P < .001). The VR-12 Physical score improved from 43 preoperatively to 55 at 2 years and remained at 56 at 5 years. The VAS pain, Tegner, and Marx scores were 0, 6, and 9, respectively, at 2 years postoperatively. There was no difference in PROMs between graft types.

Conclusion:

This study demonstrates encouraging results of suture tape augmentation of autograft ACLR for both hamstring and patellar tendon grafts. The failure rate of 1.1% at a mean follow-up of 5 years is lower than published rates for reconstruction, and PROMs results are satisfactory. The technique is safe to use and may permit a return to the preinjury sporting level with a lower chance of reinjury.
Defining Thresholds and Predictors for Achieving the Patient Acceptable Symptom State for Patient-Reported Outcome Measures After Revision Hip Arthroscopy
Authors: Maldonado David R. , George Tracy , Padmanabhan Saiswarnesh , Curley Andrew J. , Domb Benjamin G.
Published: November 2023

Background:

The Patient Acceptable Symptom State (PASS) after primary hip arthroscopy has been determined; nonetheless, the PASS still needs to be defined for revision hip arthroscopy.

Purpose:

To define minimum 2-year follow-up PASS thresholds for the modified Harris Hip Score (mHHS), Nonarthritic Hip Score (NAHS), Hip Outcome Score–Sports Specific Subscale (HOS-SSS), visual analog scale (VAS) for pain, and International Hip Outcome Tool-12 (iHOT-12) after revision hip arthroscopy, and to identify predictors of achieving the PASS.

Study Design:

Case-control study; Level of evidence, 3.

Methods:

Data were prospectively collected and retrospectively reviewed for all patients who underwent revision hip arthroscopy between April 2017 and July 2020. Patients were included if they had baseline and minimum 2-year follow-up scores for the mHHS, NAHS, HOS-SSS, VAS for pain, and iHOT-12. PASS was calculated using the anchor-based method. Receiver operating characteristic curve analysis was used to determine the thresholds for the PASS. A multivariate logistic regression was used to identify predictors for achieving the PASS.

Results:

A total of 318 patients who underwent revision hip arthroscopy met the inclusion criteria. Of those patients, 292 (91.8%) had baseline and minimum 2-year follow-up. Of this group, 68 patients (72.1% female and 27.9% male; mean age, 32.9 years) answered the PASS anchor question. Achievement PASS rates were 58.8%, 41.2%, 52.9%, 60.3%, and 52.9% for the mHHS, NAHS, HOS-SSS, VAS, and iHOT-12, respectively. The area under the curve (AUC) values for the PASS for mHHS, NAHS, HOS-SSS, VAS, and iHOT-12 were 0.912, 0.888, 0.857, 0.903, and 0.871, respectively, indicating excellent discrimination. The PASS for the mHHS was 76 (sensitivity, 0.809; specificity, 0.905), for the NAHS was 86.3 (sensitivity, 0.660; specificity, 1), for the HOS-SSS was 64.3 (sensitivity, 0.745; specificity, 0.905), for the VAS was 3 (sensitivity, 0.830; specificity, 0.905), and for the iHOT-12 was 64.3 (sensitivity, 0.745; specificity, 0.905). Body mass index (BMI) was identified as a significant predictor of achieving PASS for the NAHS (OR, 0.967; 95% CI, 0.940-0.996; P = .027), as patients with a BMI ≤25.4 had 1.03 times higher odds ratio of achieving PASS for the NAHS.

Conclusion:

After revision hip arthroscopy, the minimum 2-year follow-up PASS thresholds for the mHHS, NAHS, HOS-SSS, VAS for pain, and iHOT-12 were 76, 86.3, 64.3, 3, and 64.3, respectively. The odds ratio of achieving PASS for the NAHS was 1.03 times higher for patients with a BMI ≤25.4.
Scoping Literature Review: Experiences of Sexual and Gender Minority Older Adults, With Diagnoses of Dementia, Who Use Residential Long-Term Services and Supports
Authors: Shippee Tetyana , Rosser B. R. Simon , Wright Morgan M. , Aumock Cailynn , Moone Rajean , Talley Kristine M. C. , Duran Phil , Henning-Smith Carrie , Cahill Sean , Flatt Jason D. , Slaughter-Acey Jaime , Greenwald Samuel , McCarthy Teresa , Ross Michael W.
Published: November 2023

The number of sexual and gender minority (SGM) older adults utilizing residential long-term supports and services (LTSS) will increase in the forthcoming decades. Paradoxically, while requiring more LTSS services than their non-SGM counterparts, SGM older adults are less likely to access these services, partly due to fears of discrimination. Furthermore, SGM older adults living with Alzheimer’s disease and related dementias (AD/ADRD) present unique challenges and opportunities for LTSS facilities. This article provides a scoping review on the intersection between experiences of SGM older adults with AD/ADRD who use residential LTSS. This review identified three themes: (1) the experiences of discrimination among SGM residents in LTSS facilities, (2) the need for comprehensive staff training in residential LTSS to ensure proper care of SGM populations, and (3) the crucial role of inclusive facility policies. As the number of SGM older adults is expected to increase, further research is necessary.
Centering Student Voice to Inform Teacher Practice and Research: Validation of an Asset-Based Identities Measure
Authors: López Francesca , Gray DeLeon , Boveda Mildred , Oviedo Dynah , Ram Nilam , López Lorenzo
Published: November 2023

Collectively, measures created for research use—whether self-report or observational—have contributed to evidence underscoring the importance of ensuring teachers develop knowledge and skills to engage in asset-based pedagogy. Teachers who wish to enhance their practice, however, do not have a way to elicit students’ perspectives of their instruction with a validated instrument designed to do so. Given that student identity is a robust predictor of minoritized students’ academic and non-academic outcomes, this study reflects the development and validation of Asset-Based Identities Measure that centers student voice to formatively inform teacher practice. The iterative design of the study included expert educators, students, and a larger validation sample of N = 860 students. Cognitive interviews and focus groups contributed to the refinement of the pilot measure across three identity domains. Factor structures were examined through confirmatory factor analyses resulting in a robust measure. Use of the measure is discussed.
Our public safety system is a perfect storm
Authors: Pepler Eileen , Macnamara W. Donald
Published: November 2023

Public safety results from an effective interaction of three separate systems - public health, mental health, and policing. In too many communities today, the crisis in our mental health system creates the perfect storm. Solving the issues of silo-based care necessitates creating an oversight data management structure supporting cross-sector data integration on all levels ensuring that both operational and technical frameworks exist to maintain the security of client data. Safer communities isn’t just about being sophisticated, technologically advanced but using an intensifying laser-focus analysis on harmful criminality, and on stakeholders responsible for delivering to those in need of mental health services. The recommendations note that no one agency can solve the crisis in public safety alone. There is an urgent need for one new coordinating agency – a department in government - to eliminate the silos and act like a well-coordinated and effective service delivery network, with public commitment to outcomes and corresponding public accountability.
Strengthening health system leadership in practice
Authors: Cady Phil , Heykoop Cheryl
Published: November 2023

The field of health leadership is shifting rapidly, and there is an opportunity to learn with health leaders about what is needed to support health leadership education, research, and practice. In 2022, to augment student feedback and faculty praxis, Royal Roads University conducted 12 virtual interviews with senior health system leaders across various settings to learn how health leaders can better respond to emerging and future leadership needs and priorities facing health systems. Findings from this study informed the development of a health-specific elective for the Master of Arts in Leadership, Health Specialization program entitled Considerations for Health Systems Renewal. This elective explores the following topics that emerged from this research study: (1) an orientation to possibility; (2) emerging strategic human resource concerns; (3) healthcare innovation; (4) relational and social systems leadership; (5) polarity thinking; (6) trauma-informed leadership; and (7) Canadian healthcare networks. In this article, we share our research process and findings to arrive at these recommendations.
Effects of carbon-based nanofillers on mechanical, electrical, and thermal properties of bast fiber reinforced polymer composites
Authors: Syduzzaman Md , Chowdhury Kawser Parveen , Fahmi Fahmida Faiza , Rumi Shaida Sultana , Hassan Abir
Published: November 2023

Bast fiber-reinforced polymer composites (BFRPs) are grabbing considerable research attention due to their assertive impact on the environment and excellence in biodegradability. Though BFRPs have excellent ecological performance factors, they also lack in some cases, such as lower mechanical, electrical, and thermal properties, due to the significant moisture absorption, minimal thermal stability, and inherent nature of bast fibers. BFRPs exhibit weaker fiber/matrix interfacial adhesion as compared to synthetic fiber-reinforced polymer composites, resulting in lower mechanical properties. Nowadays, a wide variety of fiber and matrix modification techniques are practiced improving the fiber-matrix interaction, which ultimately improves the mechanical properties. Among the fiber and matrix modification techniques, nanofiller integration is the most promising one. This study reviews the impacts of introducing carbon-based nanofillers, particularly graphene and carbon nanotubes (CNT), in diversified BFRPs. The influence of carbon-based nanofillers on the mechanical, electrical, and thermal behavior of BFRPs and their potential prospects are comprehensively reviewed. The paper concludes with the challenges and difficulties in composite processing, along with the techniques for overcoming them.
Propagating the Israelite way of life in the book of Tobit and in Jubilees: Tobit and Noah as exemplary characters
Authors: Antin Katri
Published: November 2023

This study explores the fluidity of beliefs and practices depicted distinctively Israelite in the Book of Tobit and Jubilees. The comparison between Tobit’s and Noah’s characters demonstrates that their exemplarity is depicted similarly by using the two-way metaphor, but the beliefs that these characters propagate are very different. Drawing on the social identity approach, this article shows that the authors of the Book of Tobit and Jubilees compare different groups that affect which beliefs and practices characterize the ideal way of life: Different features are presented as exemplary when ethnic groups are compared to one another as opposed to when different tribes/families are compared. Similarly, the exemplary characteristics are different when common ancestry is defining for Israelite identity in comparison to when covenantal obedience is defining. The comparative context does not change only between the Book of Tobit and Jubilees but also within each book. The shift in the comparative context offers one explanation for the literary seams in the Book of Tobit.
Bernard Bornstein (1900–1977): His life and contribution to Polish and Israeli neurology
Authors: Ohry Avi , Marcinowski Filip
Published: November 2023

Bernard Bornstein (1900–1975) was one of a few Polish-Jewish neurologists who escaped the tragic fate of Jews in Nazi-occupied Poland. Educated at the University of Vienna and practicing until the war in Cracow, Bornstein in his scientific work dealt comprehensively with various neurological topics, bringing to Israeli medicine the best of pre-War European neurological diagnostics and combining them with the latest achievements of genetics. He was a teacher of many prominent Israeli neurologists. On the basis of previously unknown archival sources, the fate of Bornstein and his family during World War II was reconstructed.
Intraoperative three-dimensional navigation for surgical treatment of osteoid osteoma in the upper extremity: A series of 19 cases
Authors: Gurel Ron , Shehadeh Kathrine , Elbaz Etay , Benady Amit , Factor Shai , Ashkenazi Itay , Gortzak Yair , Sternheim Amir , Dadia Solomon , Segal Ortal
Published: November 2023

The surgical treatment for osteoid osteoma (OO) in the upper extremity is challenging due to the difficulty in locating the lesion and the crowding of sensitive structures within the anatomy. This study aimed to describe the outcomes of navigated minimally invasive radiofrequency ablation and those of navigated mini open-intralesional curettage in treating these lesions. Nineteen consecutive patients with OO in the upper limb who underwent navigated surgery were included. The average QuickDASH and Numeric Pain Rating Scale improved from 62.2 ± 23.7 to 11.7 ± 16.9 and from 8.1 ± 1.6 to 0.5 ± 1.8, respectively ( p < .01 each) following the procedure. Two complications were recorded: one patient had persistent radial nerve palsy, and one patient had transient partial radial nerve weakness. In conclusion, navigation is an important tool in the surgical treatment of OO in the upper limb. A mini open approach to identify and protect neurovascular structures is recommended.
Mapping MAiD Discordance: A Qualitative Analysis of the Factors Complicating MAiD Bereavement in Canada
Authors: Serota Kristie , Buchman Daniel Z. , Atkinson Michael
Published: November 2023

Medical assistance in dying (MAiD) is an evolving practice in Canada, with requests and outcomes increasing each year, and yet controversy is present—with a vast spectrum of ethical positions on its permissibility. International research indicates that family members who experience disagreement over their loved one’s decision to have MAiD are less likely to be actively involved in supporting patients through the practical aspects of the dying process. Family members with passive involvement in the assisted dying process may also experience more significant moral dilemmas and challenging grief experiences than those who supported the decision. Given these previous findings, we designed this study to explore the factors complicating family members’ experiences with MAiD in Canada and to understand how these complicating factors impact family members’ bereavement in the months and years following MAiD. We conducted narrative interviews with 12 MAiD-bereaved family members who experienced disagreements, family conflicts, or differences in understanding about MAiD. Documenting and analyzing participants’ experiences through storytelling allowed us to appreciate the complexity of family members’ experiences and understand their values. The analysis generated five factors that can complicate the MAiD process and bereavement for family members: family discordance, internal conflict, legislative and eligibility concerns, logistical challenges, and managing disclosure and negative reactions. To our knowledge, this is the first Canadian study that explores how family discordance can impact bereavement following MAiD. Future bereavement services and resources should consider how these complicating factors may impact bereavement and ensure that Canadians with diverse MAiD experiences can access appropriate support.
Cutaneous lesions and clinical outcomes in five cats after frunevetmab injections
Authors: Storrer Anjie , Mackie John T , Gunew Marcus N , Aslan Jeylan
Published: November 2023

Case series summary

This case series describes five cats with cutaneous adverse events after subcutaneous administration of frunevetmab, a felinised anti-nerve growth factor monoclonal antibody, including histopathological findings in one case. All cats displayed moderate to severe pruritus resulting in self-trauma to the neck and/or head, causing lesions ranging from superficial dermatitis to alopecia and ulcerations. There were no reactions at the injection sites. In one cat, clinical signs developed after the second frunevetmab dose the cat received, with no reaction noted after the first dose. For the remaining cats, clinical signs were observed after their first dose of frunevetmab. The onset of the first episode of pruritus and self-trauma was 3–18 days after the most recent frunevetmab injection. Three cats had one or more additional frunevetmab injections after the original adverse event and all had subsequent reactions. Subsequent reactions were either similar in time frame or occurred more rapidly, with similar or more severe pruritus compared with the original reactions. Treatments and outcomes varied between cases.

Relevance and novel information

Frunevetmab is a novel, monthly injectable monoclonal antibody for the management of pain associated with osteoarthritis in cats. This is the first published report detailing the nature of cutaneous adverse events associated with this treatment, and the first report of the histopathological findings.
Factors associated with house-soiling in Italian cats
Authors: Padalino Barbara , Zappaterra Martina , Felici Martina , Ricci-Bonot Claire , Nanni Costa Leonardo , Houpt Katherine , Tateo Alessandra
Published: November 2023

Objectives

The aim of the present study was to identify factors associated with house-soiling in Italian cats.

Methods

A cross-sectional online survey collected information on respondents’ and cats’ details and litter management, and whether the cat showed house-soiling. Univariable and multivariable regression models were performed using house-soiling (present/absent) and the type of house-soiling (ie, urinary, faecal, concurrent urinary and faecal) as dummy variables.

Results

Data from 3106 cats were obtained. The number of dogs and other cats in the household, the cat’s age, the number, type and location of the litter boxes, the type of litter, and the frequency of litter scooping and full replacement were retained in the final multivariable regression model for house-soiling (model P <0.001, Akaike information criterion [AIC] = 2454.30). Urinary tract diseases, the type and number of litter boxes and the number of dogs in the household were associated with urinary house-soiling (model P <0.001, AIC = 534.08), and gastroenteric/musculoskeletal diseases, number of litter boxes and litter box location were associated with faecal house-soiling (model P <0.001, AIC = 448.52). Healthy cats, the number of dogs in the household, the type of litter and litter full replacement frequency were retained in the final multivariable regression model for the concurrent expression of urinary and faecal house-soiling (model P <0.001, AIC = 411.47).

Conclusions and relevance

Meeting cats’ preferences for litter and litter box type, location, behavioural needs and strict litter hygienic conditions is recommended. Cat owners need to be educated to prevent and manage house-soiling in their cats.
Consent? At the Start, You Do Not Even Think About It. Coercive Discourse in the Awakening of Affective–Sexual Relationships in Young Women
Authors: Duque Elena , Salceda Marifa , Campdepadrós-Cullell Roger , Merodio Guiomar , Puigvert-Mallart Lídia
Published: November 2023

Extensive scientific evidence suggests that peer interactions influence sexual and affective relationships. Coercive discourse in some peer interactions has also been shown to adversely affect consent in those relationships. However, more research is needed to understand how consent (or the lack of it) is internalized during life trajectories, specifically in the awakening of sexual relationships in young women. In the research project CONSENT framework, 36 women between 18 and 25 years of age participated in interviews and communicative groups. This article presents results related to the role of consent in their life trajectories, indicating that consent is undermined by coercive discourse, significantly impacting their life trajectories, especially in the awakening of sexual relationships. The article discusses how coercive discourse is present at times when learning to decide freely is crucial and decreases consent in relationships.
Current trends in targeting the oxidative stress in glaucoma (Review)
Authors: Iorga Raluca Eugenia , Moraru Andreea Dana , Costin Dănuț , Munteanu-Dănulescu Răzvana Sorina , Brănișteanu Daniel Constantin
Published: November 2023

Glaucoma is a progressive optic neuropathy characterised by retinal ganglion cell degeneration and visual field loss. Glaucoma is considered to be the leading cause of blindness in the industrialised countries. Oxidative damage is an important pathogenic factor in glaucoma, which triggers trabecular meshwork (TM) degeneration, which then leads to intraocular hypertension. Neurodegenerative insults during glaucomatous neurodegeneration initiate an immune response to restore tissue homeostasis. However, the oxidative stress (OS) that develops during the pathogenic processes of glaucoma, along with the agerelated OS, plays a critical role in shifting the physiological equilibrium. In the TM from glaucoma donors, proinflammatory markers were found, which were induced by the activation of a stress response. Chronic changes in the composition of antioxidants found in aqueous humour may induce alterations in TM as well as in the optic nerve head cells. Highlighting the pathogenic role of reactive oxygen species (ROS) in glaucoma has implications in preventing this disease. Various clinical trials are available to test the efficacy of antioxidant drugs in glaucoma management. In this review, we discuss the OS as a therapeutic target, suggesting that the modulation of a pro-oxidant/antioxidant status might be a relevant target for glaucoma prevention and therapy.
South African emerging adults’ capacity for resilience in the face of COVID-19 stressors
Authors: Cockcroft Kate , Greyling Mike , Fouché Ansie , Ungar Michael , Theron Linda
Published: November 2023

Little is known about resilience responses to COVID-19 stressors from emerging adults in minority world contexts. In this cross-sectional study, we explored the association between self-reported COVID-19 stressors and capacity for resilience in 351 emerging adults (Meanage = 24.45, SD = 2.57; 68% female) who self-identified as Black African. We were interested in whether age, gender and neighbourhood quality influenced this association. The main findings were that higher pandemic stress was associated with a greater capacity for resilience. Older participants showed higher levels of resilience, while there was no gender difference in this regard. Those who perceived their neighbourhoods as being of a good quality also showed greater capacity for resilience, despite all participants residing in disadvantaged communities. The theoretical and practical implications of these results are considered.
Taking a look in the virtual mirror: Implications of self-observation by White individuals during online intergroup exchanges for their own and their racialized partners’ experience
Authors: Vorauer Jacquie D.
Published: November 2023

Concerns about being viewed negatively by outgroup members can have harmful implications for intergroup interaction. In line with the information search model, research suggests that trying to empathize with outgroup partners—by virtue of still involving taking outgroup members’ perspective—can lead right back to evaluative concerns. The present experiment (276 dyads) tested the model’s further prediction that—by virtue of still involving a focus on the self—stimuli that typically instantiate private self-awareness and prompt enhanced self-regulation also lead right back to evaluative concerns and their disruptive effects in interaction settings. Higher and lower prejudice White individuals (HPs and LPs) turned their self-view on or off during an online exchange with a partner with a marginalized racial background. Although there were some exceptions, results were generally consistent with predictions: Racialized individuals benefitted when HPs engaged in self-observation, but everyone was better off if LPs could not watch themselves.
The limits of cyberattacks in eroding political trust: A tripartite survey experiment
Authors: Matzkin Sharon , Shandler Ryan , Canetti Daphna
Published: November 2023

To what extent do security threats – such as cyberattacks – undermine trust in government? Fears have emerged that cyberattacks undercut public trust in government and sow doubt in democratic institutions heavily dependent on digitised systems. Nevertheless, the logic of this threat remains untested. This article presents survey experiments conducted in the United States (n = 607), the United Kingdom (n = 594), and Israel (n = 627) that examine whether cyberattacks on critical infrastructure truly undermine public trust in government and, if so, by what psychological mechanism. We exposed participants to simulations of cyberattacks against critical infrastructure before measuring the psychological and political outcomes. Our results reveal that cyberattacks do not undermine voters’ trust in the government’s ability to protect them. Furthermore, in the United States, exposure to cyberattacks heightens public trust by amplifying anger. Our findings inject a missing comparative component to the theoretical discussion of when, why, and how cyberattacks affect public trust in government.
Patterns in naturally occurring interactions in early writing instruction
Authors: Riis-Johansen Marit Olave , Myran Iris Hansson
Published: November 2023

This article examines what happens when first grade students (age six) interact and talk with each other while writing individual texts. The data for the study comprises observations and video-recordings from 26 writing lessons in two different first grade classrooms in Norway. The study builds on sociocultural theories of writing that argue that writing is an activity that unfolds within writing communities in which each writer’s knowledge and skills have the potential to become a shared resource for the participants. The analysis found that students’ interactions can be grouped into five categories: copying, unsolicited advice, subteaching, mutual commenting and ignored initiatives. Within these different patterns of interaction, students seemed to explore and practice writing in varying ways; so it is therefore useful for teachers to be aware of what type of interaction is occurring. The findings indicate that students’ interaction elicits many benefits, as students are found to practice spelling, handwriting, and composing; use and develop their writing metalanguage; and experience being writers in a writing community. At the same time, interaction can make students socially vulnerable, and advice from peers can be too focused on correctness and can be unwelcome.
Competency development for a volunteer navigation program to support caregivers of people living with dementia: A modified e-Delphi method
Authors: Huggins Madison , Puurveen Gloria , Pesut Barb , Rush Kathy , McArthur Caitlin
Published: November 2023

Caregivers of people living with dementia are pillars of the care community. Providing them with adequate support throughout their caregiving journey is essential to their quality of life and may also contribute to improving the care of people living with dementia. Nav-CARE (Navigation - Connecting, Advocating, Resourcing, Engaging) is a volunteer-led navigation program that provides support to older adults with life-limiting illnesses who are living in the community. However, Nav-CARE does not provide support directly to caregivers of people living with dementia. To adapt Nav-CARE to support caregivers, we needed to establish caregivers’ needs and the competencies volunteer navigators should be trained in to support caregivers to meet these needs. To do so, a modified e-Delphi method was utilized, which consisted of administering three sequential questionnaires to a panel of 35 individuals with expertise in a variety of dementia related domains. Through this, two final lists of 46 caregivers’ needs and 41 volunteer competencies were established to inform the development of volunteer navigator training curriculum. Findings suggest that trained volunteer navigators may be able to support caregivers of people living with dementia throughout the disease trajectory and can be used to inform the development of future dementia navigation programs.
Humanities in collaboration: Mentored teaching experiences among humanities graduate students
Authors: Kruse Nathan B , Emmons Kimberly K , Powers Trista L , Williams Derrick L , Wolken Christine C
Published: November 2023

Preparing graduate students for teaching careers in academia can involve myriad approaches. One such approach is facilitating authentic teaching opportunities for graduate students. The purpose of this multiple case study was to chronicle the perspectives of four humanities graduate students as they participated in a mentored teaching experience at a community college. Specific emphases included the evolution of participants’ teacher identity and how a mentored teaching experience shaped participants’ future career goals. Data sources consisted of semi-structured interviews, classroom observations, journal reflections, and classroom artifacts. Participants identified the fundamental importance of mentor faculty and diverse students as drivers in their own pedagogical development and reflected on the value of interpersonal connections in education. Implications include the need for more pedagogical transparency and discussion in humanities graduate education, as well as the potential of constructing cross-disciplinary and cross-institutional collaborations to support graduate students’ professional development.
Effect on muscle strength after blood flow restriction resistance exercise in early in-patient rehabilitation of post-chronic obstructive pulmonary disease acute exacerbation, a single blinded, randomized controlled study
Authors: Lau Chung Wai , Leung Siu Yin , Wah Shu Hong , Yip Choi Wan , Wong Wei Yin , Chan Kin Sang
Published: November 2023

Background

Early commencement of rehabilitation might counteract the loss of muscle strength due to a chronic obstructive pulmonary disease acute exacerbation (COPDAE). Blood flow restriction resistance exercise (BFR-RE) using a low intensity of training load has demonstrated muscle strength gain in varieties of clinical populations. This trial aimed at studying the efficacy and acceptability of BFR-RE in patients with post-COPDAE which was not reported before.

Method

A prospective, assessor blinded, randomized controlled study with 2-week in-patient rehabilitation program with BFR-RE was compared to a matched program with resistance exercise without BFR in patients with post-COPDAE. The primary outcome was the change of muscle strength of knee extensor of dominant leg. The secondary outcomes included changes of hand grip strength (HGS), 6-minute walk test (6MWT) distance, short physical performance battery (SPPB) scores, COPD assessment test (CAT) scores; acceptability and feasibility of BFR-RE; and 1-month unplanned re-admission rate.

Results

Forty-Five post-COPDAE patients (mean age = 76 ± 10, mean FEV1%=49% ± 24%) were analyzed. After training, BFR-RE group and control group demonstrated a statistically significant median muscle strength gain of 20 (Interquartile range (IQR) 3 to 38) Newton(N) and 12 (IQR -9 to 30) N respectively. BFR-RE group showed a significant change in SPPB scores, but not in 6MWT distance and HGS after training. Between groups did not have statistically significant different in all primary and secondary outcomes, though with similar acceptability. Drop-out rate due to training-related discomfort in BFR-RE group was 3.7%.

Conclusion

BFR-RE is feasible and acceptable in patients with post-COPDAE. A 2-week inpatient pulmonary rehabilitation with BFR-RE improved muscle strength of knee extensors, but not a greater extent than the same rehabilitation program with resistance exercise without BFR. Further studies could be considered with a longer training duration and progression of resistance load. [ ClinicalTrials.gov Identifier: NCT04448236].
Aerobic Treadmill Exercise Upregulates Epidermal Growth Factor Levels and Improves Learning and Memory in d-galactose-Induced Aging in a Mouse Model
Authors: Guo Cheng , Kong Xiaoyang , Fan Yongzhao , Zhang Rihui
Published: November 2023

Previous studies have demonstrated that exercise improves cognitive function in Alzheimer’s disease mice but the exact mechanism needs further studies. This research aimed to study the effects of aerobic treadmill exercise on epidermal growth factor (EGF) levels and learning and memory in d-galactose-induced aging in a mouse model. Forty male Kunming mice were analyzed in this study and randomly divided into 4 groups: control (C group), aerobic exercise (AE group), d-galactose (D-gal group), and d-galactose + aerobic exercise (D-gal + AE group). The C and AE groups received a daily mid-scapular subcutaneous injection of .9% saline for 40 days. Mice in the D-gal and D-gal + AE groups were subcutaneously injected with d-galactose (1.25 mg/kg) once daily for 40 days. The mice in the AE group and D-gal + AE group completed 40 days of aerobic treadmill exercise. Learning and memory were evaluated by step-down tests. Specifically, 24 h after the behavioral test, blood was collected and brain tissue was extracted, and superoxide dismutase (SOD) and acetylcholinesterase activities were detected. The neurons in the CA1 and CA3 regions of the hippocampus were counted by Nissl staining. The number of EGF-positive cells was observed by immunohistochemical methods. In the learning test, the reaction time in the D-gal group increased significantly ( P < .05), while the error numbers in the D-gal group tended to decrease compared with AE, D-gal + AE, and C groups. In the memory test, the latency of mice in the D-gal group was lower, while the error in this group was higher than in the other groups ( P < .05). The activities of SOD and acetylcholinesterase were lower in the D-gal group than in the other groups ( P < .05). The number of EGF-positive cells and neurons in the hippocampal CA1 and CA3 regions in the D-gal + AE group was higher compared to those in the D-gal group ( P < .05), and lower in groups with mice that were not injected with d-galactose. Aerobic treadmill exercise inhibited SOD activity, increased EGF-positive cells, and decreased neuronal death and apoptosis, thereby improving learning and memory in the mouse model of d-galactose-induced aging.
Successful Endovascular Salvage of Viabahn Stent Release Malfunction Using a Cutting Balloon: A Case Report
Authors: Wang Yusheng , Zhang Xiaosong , Li Da
Published: November 2023

In the past two decades, the method of endovascular therapy, particularly utilizing covered stents, has been widely employed to treat arteriovenous fistulas (AVF) following traumatic injury. In this report, we present a case study of a patient with post-traumatic femoral arteriovenous fistula treated using a Viabahn endoprosthesis, during which a rare occurrence of stent deployment obstruction was overcome via successful endovascular intervention. Leveraging the unique release line-based deployment mechanism of the Viabahn stent, we were able to adroitly respond to this emergency situation by adopting a suitable approach via minimally invasive endovascular means, and ultimately resolving the impasse. This approach averted the significant trauma associated with open surgical procedures.
Building a Functional Resonance Analysis Method Model: Practical Guidance on Qualitative Data Collection and Analysis
Authors: McGill Alexis , McCloskey Rose , Smith Doug , Salehi Vahid , Veitch Brian
Published: November 2023

The Functional Resonance Analysis Method (FRAM) is a novel research methodology that uses qualitative data collection methods to map and model complex healthcare processes by identifying and depicting the cumulative activities required to produce an outcome. The FRAM aims to identify the variability that can emerge in a process when healthcare activities are performed under dynamic conditions. With this knowledge, health care system design, safety, and quality improvement recommendations can be developed with a greater understanding of everyday process functionality. Researchers interested in using the FRAM require both an understanding of the methodology itself, as well as an understanding of how to effectively plan and conduct qualitative research. The purpose of this paper is to provide practical guidance to researchers on planning and operationalizing qualitative data collection and analysis methods to inform the building of a FRAM model. A combination of literature and practical experience will be used to examine and suggest appropriate ways for researchers to carry out this work.
Long-term donor site outcome after second toe transfer for congenital hand differences
Authors: Hellevuo Camilla , Jokihaara Jarkko , Kaistila Tiina , Leppänen Olli V. , Vilkki Simo K.
Published: November 2023

This study evaluates the long-term donor site outcomes after second toe transfers for congenital hand differences performed during childhood. In total, 25 toe transfers in 18 patients were followed up for a mean period of 17.4 years. We examined the patients clinically, radiologically and with a gait analysis system. Patient-reported outcome measures were collected. The patients were asymptomatic and there were no problematic clinical or radiological findings. Patients expressed high levels of satisfaction. The results were consistent, regardless of the resection level in the toe transfer or whether the operation was unilateral or bilateral. No postoperative complications or late reoperations on the foot were observed.

Level of evidence IV
A three-dimensional computed tomography study of the palmar ulnar corner fragment in distal radial fractures
Authors: Hubbard James , Berry David , Chauhan Aakash , Casstevens Chris , Shin Alexander Y. , Abrams Reid A.
Published: November 2023

Fixing palmar ulnar corner fragments of distal radial fractures can be challenging. We described the palmar ulnar corner fragment morphology in a retrospective cohort study of 40 patients who underwent preoperative wrist computed tomography scans. Palmar ulnar corner fractures were categorized based on articular cross-sectional area, sagittal angulation relative to the radius long axis, palmar cortical length, radioulnar width and associated palmar radiocarpal subluxation. Three types emerged: type 1 fragments involved 37% (SD 10) of the radiocarpal articular surface and were extended in the sagittal plane; type 2 fragments involved 28% (SD 10) of the articular surface and had a long palmar cortex, of which 57% had palmar carpal subluxation; and type 3 fragments involved 13% (SD 2) of the articular surface, had a short palmar cortex and all had palmar carpal subluxation. Understanding palmar ulnar corner fragment morphology may guide optimal reduction and fixation strategy and prevent palmar radiocarpal subluxation, especially in type 3 fractures.

Level of evidence IV
Preventability of stroke during pregnancy and postpartum
Authors: Ding Jia Jennifer , Mitta Srilakshmi , Kole-White Martha , Roth Julie , Malhamé Isabelle
Published: November 2023

Background

The preventability of strokes during pregnancy and postpartum is understudied.

Methods

We identified patients with ischemic and hemorrhagic strokes in pregnancy or within 12 weeks postpartum between 2009 and 2020 at an obstetric teaching hospital. We described the clinical course of the included cases. A multi-disciplinary panel adjudicated each occurrence of stroke according to a modified classification system for preventability.

Results

Fifteen patients experienced a stroke during pregnancy or postpartum. Precisely, 60% presented with a headache, and 47% of events were complicated by severe obstetrical hypertension. Two cases were thought to be “possibly preventable” due to delays in presentation to care and miscommunication regarding hypertension management goals.

Conclusion

In a cohort of pregnant and postpartum patients with stroke at a tertiary-care center, strokes may be prevented by future initiatives focusing on patient and provider education regarding early warning signs of pregnancy-associated stroke and hypertension thresholds and management specific to pregnancy.