bluuebunny/crossref_metadata_2025 huggingface dataset:
THE METHODS TO DEVELOP CHILDREN’S SPEECH IN FOREIGN LANGUAGES DURING PRE-SCHOOL EDUCATION
Authors:   Samarqand davlat universiteti, Mardonov Eshim
Published: November 2023

The article examines the ways to enhance children's speech in foreign languages at a young age and suggests possible methods to implement in pre-school education. The authors discuss the challenges and provides relevant solutions and examples.
They don’t need to be forgiven
Authors: Priego Ernesto
Published: November 2023

The thing is, many of us can relate-
The Lockdown Chronicles 25: Ralph
Authors: Priego Ernesto
Published: November 2023

Ralph gives another online lecture.
Time Machine: Where I discussed Mexican comic books with Greg Gransden in 2002
Authors: Priego Ernesto
Published: November 2023

An 18-year old clip of me being interviewed by Gregory Gransden on Mexican Comic Books for Greg’s 2002 Historietas documentary.
The Lockdown Chronicles Year 2: Back to School?!
Authors: Priego Ernesto
Published: November 2023

Back to School?!
FWIW: A list of stuff I published in 2020
Authors: Priego Ernesto
Published: November 2023

This is most likely my last post from 2020. I have deposited on figshare a basic sheet listing a selection of my articles, blog posts and outputs I published openly during 2020.
The Lockdown Chronicles 12: Giovanni
Authors: Priego Ernesto
Published: November 2023

Giovanni has stories to tell.
New article: Searching for a Common Ancestry: Linguistic and Biological Analogies in Comic Art
Authors: Priego Ernesto
Published: November 2023

Announcing an article coauthored with evolutionary biologist Dr Ricardo González Trujillo is now out.
The Lockdown Chronicles 16: Albert
Authors: Priego Ernesto
Published: November 2023

Albert is bored.
Comics as COVID-19 Response: Now Deposited ‘Green’ Open Access
Authors: Priego Ernesto
Published: November 2023

We have deposited the accepted manuscript of “Comics as COVID-19 Response: Visualising the Experience of Video-conferencing with Ageing Relatives” in City Research Online.
The Lockdown Chronicles 40: Daniel
Authors: Priego Ernesto
Published: November 2023

Daniel tweets a thread.
Clima laboral en el área de cajas de la tienda Wong - Ate. Lima 2019
Authors: Cuello Ñahuis Celia Virginia , Lozano Chavarry Lusvith Milagros
Published: November 2023

La presente investigación tiene como objetivo determinar el nivel de clima laboral en el área de cajas de la tienda Wong de Ate, en Lima, 2019; así como, el nivel de cada una de sus dimensiones: Autorrelación, involucramiento laboral, supervisión; comunicación y condiciones laborales. Esta investigación se desarrolló bajo el paradigma cuantitativo siendo de tipo descriptiva y corte transversal, con un diseño no experimental. La muestra estuvo conformada por 48 trabajadores de caja de la referida empresa. Para la recolección de datos se empleó la técnica de la encuesta y como instrumento un cuestionario; el cual arrojó como resultado que el 81% de los encuestados consideran que la empresa tiene un buen clima laboral en el área de cajas. Asimismo, se realizó la medición de las dimensiones que conforman el clima laboral, las cuales arrojaron que todas tienen buenos niveles de percepción.
Comunicación interna y satisfacción laboral de los trabajadores del área financiera de la Universidad Peruana Unión - Lima, 2019
Authors: Ramírez Ishuiza Raquel , Rengifo Del Águila Thalía Marimar , Rodríguez Mamani Karina
Published: November 2023

En la actualidad es muy importante los procesos de interacción entre los trabajadores de cualquier organización. En tal sentido, la presente investigación tiene como objetivo determinar la relación que existe entre la comunicación interna y la satisfacción laboral de los trabajadores del Área Financiera de la Universidad Peruana Unión-Lima, 2019. En base esto la investigación tiene un diseño descriptivo, correlacional, transversal cuya muestra es de 20 trabajadores. Se aplicó como instrumento un cuestionario organizado en 2 secciones de 15 items cada una. Dando como resultado que la comunicación interna alcanza un 50% y se ubica en un nivel moderado frente a la comunicación organizacional e interpersonal. Por otra parte, la satisfacción laboral alcanza un 45% y se ubica en un nivel moderado frente a satisfacción en el trabajo y remuneraciones. Esto indica que la comunicación al ser positiva identifica la satisfacción laboral de los trabajadores. Finalmente, se concluye que la relación entre las variables contrastadas es fuerte.
Estrategias de marketing y posición competitiva en institución civil de Cochabamba, Bolivia.
Authors: Claros Andia Mauricio
Published: November 2023

En los últimos años se incrementó la competencia de instituciones o empresas que ofrecen cursos de formación aeronáutica a precios más bajos y en menoscabo de la calidad educativa. Por otra parte, el Instituto Nacional de Aviación Civil – INAC no cuenta con un personal dedicado al área de marketing. En tal sentido, la presente investigación se planteó como objetivo el Diseñar estrategias de marketing para mejorar la posición competitiva del Instituto Nacional de Aviación Civil – INAC en la ciudad de Cochabamba para la gestión 2022. Por ello, la investigación se enmarcó en los paradigmas cualitativo– cuantitativo, de tipo mixto-descriptiva. La recolección de datos se realizó con las técnicas: Encuesta y observación. Para la primera se empleó como instrumento un cuestionario, que registró la percepción de 218 estudiantes en cuanto a los factores que rodean la institución. Este instrumento consta de 10 preguntas. Seguidamente, se empleó una matriz FODA que registró los factores internos y externos que inciden en la organización. Finalmente, se elaboró una propuesta de plan de marketing para mejorar la posición competitiva del INAC
Humanities Education in the U.S. Rural South: Design, Development, and Practice
Authors: Walters Katherine , Kopcha Theodore , Lawton Christopher
Published: November 2023

The purpose of this paper is to present the results of a humanities education project that took place in a middle school in the rural U.S. South. Through a partnership between a state university and local school system, K-12 teachers engaged in two years of professional development on the integration of humanities education into the regular curriculum through project-based learning (PBL). During this project, teachers were required to personally and professionally engage with racial tensions rooted in the history of the local community as they learned to implement their PBL activities. This context is central to the design and implementation of the project as presented in this paper. We detail three learning strategies that emerged and how these were taken up by teachers: the personalization of history, historical perspective taking, and modeling a critical position. We discuss the implications of these strategies for integrating PBL and humanities education in a way that attends to socio-cultural-historical contexts. Implications for the practice of learning design in similar contexts are also discussed.
Introduction to the Special Issue
Authors: Bogard Treavor , Carr-Chellman Alison
Published: November 2023

This special issue of JAID begins to bridge the gap between the theories of social emotional learning/trauma informed learning with instructional design offering specific cases of design and development projects that illustrate the confluence of these two broad areas. We share these articles with our ID community in the hopes of creating principles for “compassionate instructional design” (Thomas et al., 2019) through a collection of practitioner cases and research articles on applied instructional design practices that are responsive to trauma-affected learners, and which highlight the complexities of the learning context of the learners being served.
Building Preservice Teacher Resiliency with Trauma-Informed Case Based Instruction
Authors: Frank Catherine , Bogard Treavor
Published: November 2023

At least one in four children in the United States has experienced one or more traumatic events (National Child Traumatic Stress Network Schools Committee [NCTSN], 2008). Children exposed to trauma bring a host of psychological and physical stressors to the classroom. Teachers can positively impact a student's ability to cope with these events and develop resilience (Brooks, 1994), but not without a physical and emotional toll on their well-being. This paper investigates one teacher education program's attempt to better support preservice teachers (PTs) in meeting these challenges by examining the impact of trauma-informed case-based instruction on PTs self-reported resilience and efficacy with Trauma Informed Instructional Practices (TIIP). Before partaking in a teacher education summer study abroad program, 26 PTs completed both the Conner-Division Resilience Scale-10 (CD-RISC) and Teacher Self-Efficacy Scale (TSES) to determine baselines for resilience and efficacy. During the program, eight PTs participated in a special topics course on trauma-informed practices utilizing case-based instruction (treatment group). At the completion of the program, all 26 PTs were reassessed on both scales. Results indicated that PTs made significant gains on both measures, but those who were in the trauma-informed case-based instruction group had significantly greater gains in resiliency than the control group. The findings support the use of case-based instruction for enhancing PTs’ resiliency. Implications are provided for embedding resiliency scaffolds for case-based reasoning through a trauma-informed lens.
Special Issue Interview Feature
Authors: Bogard Treavor , Carr-Chellman Alison
Published: November 2023

In extending the conversation around trauma-informed instructional design, one of the key assets we utilized for this special issue of JAID was the text, Trauma-responsive schooling: Centering student voice and healing by Lyn Brown, Catharine Biddle and Mark Tappan (2022). As editors, we felt that our readers would benefit from learning a little more about this resource as well as some scaffolded linkages between the trauma-informed literature and the traditional approaches to instructional design. We were fortunate to have the opportunity to interview two of the authors to help make this linkage more clear in this special issue.
Research on the Development Issues and Strategies of China’s Digital Culture Industry
Authors:   Yixin Publisher, Jin Yanjun , Cao Luhao
Published: November 2023

With the rapid growth of China’s digital culture industry and the expanding market potential, the industry's development has become an essential avenue for marketizing the industrial economy. However, as China's digital culture industry strives to strengthen its core and make strides onto the international stage, it grapples with developmental challenges such as a weak theoretical foundation, a lack of content innovation, inadequate legal and regulatory oversight, and an imbalanced industrial structure. In light of these issues, this study conducts an analysis of the aforementioned challenges within China's digital culture industry. The goal is to identify suitable strategies and pathways for its advancement, thereby making a valuable contribution to the industry’s growth in China.
Enhancing University Course Evaluation and Personalized Learning through Artificial Intelligence Technology
Authors:   Yixin Publisher, Ma Dongjun
Published: November 2023

With continuous advancements in education and the rapid proliferation of artificial intelligence technology, leveraging AI to improve university course evaluation and personalize learning experiences has garnered significant interest. This article aims to investigate the effective utilization of artificial intelligence technology in enhancing university course evaluation and achieving personalized learning outcomes. Firstly, it provides an overview of the current landscape of university course evaluation and personalized learning while highlighting the limitations of existing methodologies. It then delves into the application of artificial intelligence technology to address these challenges, discussing the utilization of machine learning algorithms for course evaluation, personalized recommendations, and student data analysis. In conclusion, the article summarizes the potential impact of artificial intelligence technology on university course evaluation and personalized learning.
Evaluation of nutritional quality, contamination, adulteration and preservative quality of different sources of milk
Authors: A.K.M.H Kober, , M.S. Bari, , S Morshed, , M.M Momin
Published: November 2023

The present study was conducted at Dairy Science laboratory of Chittagong Veterinary and Animal Sciences University to evaluate nutritional quality, contamination, adulteration and preservative status of different sources of fluid milk. Milk samples were collected from farm, vendors and departmental stores. Test performed to evaluate the milk samples were chemical (% of butter fat, solids-not-fat and protein), added preservatives, adulteration status and microbial population (standard plate count, coliform and salmonella count). Results indicate that available market milk irrespective of brand maintaining the Bangladesh Standard Testing Institute (BSTI) standards as far as butter fat, solids- not-fat, protein and microbial quality is concerned. The nutritional and microbial quality of farm produced milk (FPM) was good except high coliform count. The nutritional and chemical quality of FPM and market milk (MM) of all five brands were satisfactory but vendors supplied milk was below standard due to water adulteration. Microbial quality of MM of all five brands was very safe for human consumption. High fat content even after watering and presence of formalin in 8% samples of vendor supplied rural milk (VSRM) indicates evening milk of previous day might be mixed with morning milk of next day. It may be concluded that these adulterants and preservatives in milk may cause severe public health related problems.
Effects of high energy feeding on estrus synchronization and conception rate of Black Bengal goats under semi-intensive system
Authors: M.K.I Khan, , M.J Khatun, , Azizunnessa
Published: November 2023

The research was conducted to study the estrus synchronization and artificial insemination in Black Bengal goats under two feeding regimes in semi-intensive system. For estrus synchronization, the palpation of udder of does and the buck effect were studied. It was observed that the palpation method showed higher estrus rate than the buck effect. Goats were artificially inseminated by using vaginal speculum and locally developed inseminating device and it was found that about 50% goats conceived. The conception rate of artificial insemination was lower than the natural mating for both groups. It was observed that both, palpation and buck effect methods were lower than the hormonal method for estrus behaviour. However, palpation and buck effect methods are mainly managemental and are less costly than the hormonal method.
Detection and culture feasibility of a soil nematode (Panagrellus redivivus), a potential live feed for prawn larvae in Bangladesh
Authors: M Mostafa, , M.G Sarower, , Al-Imran  , M.S Parvez, , Hasanuzzaman A.F.M.
Published: November 2023

The free-living soil nematode, Panagrellus redivivus is recently known to be an inexpensive, standardized and permanently available food source for first feeding fish and crustacean larvae. The present study was aimed mainly at the development of a suitable culture technique of the species P. redivivus so as to be used as live food for the prawn larvae. The study has got the species morphologically detected in the local soil ground, which was found available under some specific environmental condition. About 30% of soil moisture, pH value of 7, 200 C temperatures and 5 cm soil depth were found better for higher availability and yield of the species. For culture feasibility, the experiments were conducted using different culture media with a combination of different incubation temperatures (22, 24, 25, 26, 27 and 280 C) and incubation periods (8, 10, 12, 14, 16, 18 and 20 days). Five different media (oatmeal, oatmeal with sunflower oil, cereal, raw potato and boiled potato) were used for the mass production of this nematode where the local and cheap boiled potato media was observed as the most successful and feasible one followed by the oatmeal media. The mass production of the species was found most suitable at the temperature of 260 C on around 14th day of culture period. A good quantity, 1, 50, 032±9, 285 individuals of nematodes were harvested highest from 1 gm of boiled potato media. This new technique for mass production of P. redivivus would enable fish and prawn hatchery operators to an alternative live food item to the highly expensive Artemia which is commonly used in Bangladesh.
The Impact of Public Healthcare Expenditure and Other Determinants on Life Expectancy in Nigeria
Authors:   Garden City Premier Business School, Port Harcourt-Nigeria, Opuala-Charles Silva , Tele Ikuru Mina
Published: November 2023

This study’s core objective is to empirically investigate the impact of public healthcare expenditure and other determinants on life expectancy in Nigeria for the period 1981 to 2018, with the aim of proffering policies to improve life expectancy. Grossman’s health model was used to analyze life expectancy as a function of gross domestic product (GDP), government health expenditure, inflation, secondary school enrolment, food production, and urban population. The autoregressive distributed lag (ARDL-bounds) technique, Granger causality test based on Toda Yamamoto approach, and Augmented Dickey-Fuller test, was utilized to analyze the data. The results show a long-run causal relationship between life expectancy and the variables: per capita income, government health expenditure, inflation rate, secondary school enrolment, and urbanization in Nigeria. Thus, highlighting the significant long-run impact of public healthcare expenditure on life expectancy at birth in Nigeria. Based on the study’s findings, key recommendations for Nigeria to improve the life expectancy of its citizenry were; to increase its public healthcare expenditure and GDP per capita expenditure, address issues of inadequate and insecure food production, develop new regional cities to cut down rural-urban drift, reduce inflation and ensure price stability. Keywords: Life Expectancy; Public Healthcare Expenditure; Income Per Capita
The influence of pituitary volume on the growth response in growth hormone-treated children with growth hormone deficiency or idiopathic short stature
Authors: Oh Jun Suk , Sohn Beomseok , Choi Youngha , Song Kyungchul , Suh Junghwan , Kwon Ahreum , Kim Ho-Seong
Published: November 2023

Purpose: Magnetic resonance imaging (MRI) can be used for assessing the morphology of the pituitary gland in children with short stature. The purposes of this study were: (1) to determine if pituitary volume (PV) can distinguish patients with growth hormone (GH) deficiency from those with idiopathic short stature (ISS), (2) to validate an association between PV and severity of GH deficiency, and (3) to compare PV between good and poor response groups in children with GH deficiency or ISS after 1 year of treatment.Methods: Data were collected from the medical records of 152 children with GH deficiency or ISS who underwent GH stimulation test, sella MRI, and GH treatment for at least 1 year. Estimated PVs were calculated using the formula of an ellipsoid. We compared the PVs in patients with GH deficiency with those of patients with ISS. In addition, we assessed the association between PV and severity of GH deficiency, and we assessed growth response after treatment.Results: No difference was observed in PV between patients with GH deficiency and those with ISS. The severity of the GH deficiency seemed to be associated with PV (P=0.082), and the height of the pituitary gland was associated with severity of GH deficiency (P<0.005). The PV in the good response group was less than that of the poor response group in patients with GH deficiency (P<0.005), and PV showed no association with responsiveness to GH treatment in patients with ISS (P=0.073).Conclusion: The measurement of PV cannot be used for differential diagnosis between GH deficiency and ISS. In patients with GH deficiency, PV tended to be smaller as the severity of GH deficiency increased, but the difference was not significant. PV may be a good response predictor for GH treatment. Further studies, including a radiomics-based approach, will be helpful in elucidating the clinical implications of pituitary morphology in patients with short stature.
ENDF/B-VIII versus ENDF/B-VII: What’s Different?
Authors: Cullen Dermott E.
Published: November 2023

Recently the new ENDF/B-VIII library was released; this completely replaces the earlier ENDF/B-VII library. One of the first questions we ask about a new library is: What’s Different? Here I attempt to at least partially answer this question. I present results in both tabulated form (so you can quickly determine if any evaluations of interest to you have changed), and graphic form (so that you can see how much evaluations have changed and in what energy ranges).
Karakteristik Kimia dan Organoleptik Otak-Otak Ikan Ekor Kuning (Caesio erythrogaster) dengan Penambahan Tepung Tapioka dan Tepung Sagu
Authors: Dewi Astuti Suhartin , Astuti Juni , Syahriati Syahriati
Published: November 2023

Otak-otak ikan merupakan produk gel dari daging ikan yang dicampur dengan tapioka dan bumbu-bumbu seperti garam, gula, santan kental, bawang putih, bawang merah, dan lada. Ikan ekor kuning digolongkan sebagai ikan laut yang mengandung protein tinggi dan asam lemak omega 3 dan 6. Ikan ekor kuning cocok dibuat otak-otak karena mempunyai daging yang lembut, berwarna putih, dan berdaging tebal. Penelitian ini bertujuan untuk diversifikasi produk otak-otak berbahan baku ikan ekor kuning dengan perlakuan variasi penambahan tepung sagu dan tepung tapioka. Karakteristik kimia yang diamati meliputi uji kadar air, protein, lemak, dan kadar abu. Tingkat kesukaan konsumen pada produk otak-otak diuji secara organoleptik terhadap warna, aroma, citarasa, serta tekstur.Otak-otak yang terbuat dari ikan ekor kuning dengan perlakuan A1 (75 persen tepung tapioka dan 25 persen tepung sagu), A2 (50 persen tepung tapioka dan 50 persen tepung sagu), dan A3 (25 persen tepung tapioka dan 75 persen tepung sagu), masing-masing mempunyai kadar air: 58,97, 58,12, 59,34 persen. Protein: 6,10, 5,42, 4,49. Lemak: 0,52, 0,75, 059 persen. Abu: 1,68, 1,72, 1,63 persen. Uji organoleptik pada otak-otak ikan yang dibuat dari ikan ekor kuning memiliki rentang nilai 3 sampai 5 (aga k suka sampai sangat suka). Perlakuan A1 (25 persen tepung tapioka dan 75 persen tepung sagu) paling disukai oleh panelis dari segi warna, citarasa, dan tekstur.
Analisis Pola Distribusi Dan Penetapan Harga Hasil Tangkapan Ikan Di Pangkalan Pendaratan Ikan (PPI) Labuang Maros
Authors: Ramadani Soraya , Ghadi Jasmani , Khatimah Khusnul
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pola distribusi hasil tangkapan ikan pada tiga musim penangkapan di Pangkalan Pendaratan Ikan Labuang, penetapan harga hasil tangkapan ikan di Pangkalan Pendaratan Ikan Labuang, dan faktor apa  saja yang mempengaruhi distribusi ikan di Pangkalan Pendaratan Ikan Labuang. Pengambilan sampel penelitian ini adalah nelayan,pedagang pengumpul, pedagang perantara, dan pedagang eceran di pangkalan pendaratan ikan Labuang Kelurahan Pattuadae Kecamatan Turikale Kabupaten Maros. Untuk mengolah data, digunakan analisis deskriptif kualitatif, rumus penetapan harga Margin, dan regresi linear berganda. Hasil penelitian menunjukkan bahwa pola distribusi ada dua saluran yaitu:

Nelayan - Pedagang Pengumpul - Pedagang Perantara - Pedagang Pengecer - Konsumen

2. Nelayan - Pedagang Pengumpul - Pedagang Perantara - Konsumen

Penentuan pengambilan keuntungan ditentukan oleh pedagang dan  bersifat tidak menentu. Nilai keuntungan tersebut merupakan nilai maksimal yang ditentukan pedagang. Nilai keuntungan dapat berubah sesuai dengan transaksi pasar yang memungkinkan terjadinya tawar menawar. Faktor distribusi harga jual ikan (X1), jumlah tangkapan (X2), biayal (X3), lembaga pemasaran, permintaan konsumen dan musim berpengaruh nyata terhadap jumlah ikan yang terjual pada α = 0,05 (T-tabel = 1,68).
Perspectivas internas y externas: artículos 258 y 291 de la Constitución de Panamá
Authors: Geneteau Real Garritt
Published: November 2023

El presente trabajo se basa en el análisis de los artículos 258 y 291 de la Constitución Política de Panamá, desde su origen y evolución histórica constitucional, a fin de examinar ciertos episodios ocurridos en nuestro país, partiendo de un enfoque científico. Este escrito posee una perspectiva interna emanada de la misma fuente constitucional, y una perspectiva externa que vendría siendo la legislación panameña.
La resolución por incumplimiento de contrato
Authors: De Las Casas Salazar Víctor Raúl
Published: November 2023

El presente artículo refiere a la “condición resolutoria tácita” prevista en el artículo 1009 del Código Civil, el cual no constituye una verdadera condición, toda vez que guarda importantes diferencias con la condición resolutoria que aparece regulada en el mismo texto legal. Se trata de una forma sui generis de extinción de la obligación, la cual puede ser ubicada en el régimen de las ineficacias contractuales. De manera general, encuentra su fundamento en el incumplimiento de una parte, frente a otra que cumple o se allana a cumplir lo que le incumbe, aunque esta regla no tiene un alcance absoluto, toda vez que en nuestro ordenamiento podemos encontrar diversos supuestos en los cuales procede demandar la resolución del contrato pese al hecho que la parte demandante no haya cumplido con su obligación.
Derechos humanos y participación política de las mujeres
Authors: Martínez Tamara
Published: November 2023

El presente artículo parte del cuestionamiento de por qué se hace necesario distinguir los derechos de las mujeres de los derechos humanos en general, sus necesidades específicas, tanto como el reconocimiento de sus aportes a la sociedad. A un año de celebrarse nuevas elecciones generales en Panamá, se desarrollan los procesos democráticos internos de los partidos políticos para elegir directivas y convencionales, más persiste la baja participación política de las mujeres en dichos procesos, escasa presencia en los órganos directivos de los partidos políticos, y los múltiples desafíos para sustentar el derecho de la mitad de la población a participar en la toma de decisiones en condiciones de igualdad.
Un universo de una galaxia, el descubrimiento de las galaxias y el cambio a los enfoques modernos del cosmos
Authors: Smith Robert W. , Polzella Silvia
Published: November 2023

Los astrónomos de finales del siglo diecinueve y principios del veinte estaban muy poco interesados en el universo en general, en su historia y en lo que había más allá de nuestro sistema galáctico, así como en lo que a veces se denomina cosmos termodinámico. Algunos estaban muy preocupados por la estructura de nuestro propio sistema galáctico, pero los astrónomos no desempeñaban prácticamente ningún papel en los debates de finales del siglo diecinueve sobre la naturaleza más amplia del cosmos. El universo infinito más allá de nuestro sistema estelar era un territorio que los astrónomos profesionales estaban más que contentos de dejar a los matemáticos, físicos, filósofos y algunos divulgadores. En este artículo examinaré estas actitudes y por qué y cómo cambiaron. A continuación, hablaré del descubrimiento de las galaxias, que será el tema central de la última sección del artículo
Publicación original: Smith, R. W. (2015). A One Galaxy Universe, the Discovery of Galaxies and the Shift to Modern Approaches to the Cosmos. En K. Freeman, B. Elmegreen, D. Block, & M. Woolway (Eds.), Lessons from the Local Group (pp. 401-411). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-319-10614-4_33
Factores de riesgo para infecciones del torrente sanguíneo asociados al uso de catéter venoso central en la Unidad de Cuidados Intensivos Pediátricos del Instituto Nacional de Salud del Niño
Authors: Aburto Torres Christian , Tantaleán Da Fieno José , Nakachi Graciela , Tasayco Jaime , Becerra Rosario , León Rosa , Santos Alejandro , Acosta María
Published: November 2023

Objetivo: Determinar factores de riesgo para las Infecciones del Torrente Sanguíneo (ITS) asociados a CatéterVenoso Central (CVC) en pacientes de la Unidad de Cuidados Intensivos Pediátricos (UCIP) del InstitutoNacional de Salud del Niño (INSN).Materiales y métodos: Estudio de cohortes prospectivo en la UCIP del INSN. Participantes: Pacientes admitidosen la UCIP-INSN entre el 1 de junio del 2007 hasta el 31 de mayo del 2008. Intervenciones: Ninguna. Mediciónde resultados: Desarrollo de ITS asociadas al uso de CVC desde la admisión hasta 48 horas después del altade la UCIP.Resultados: De 183 pacientes, 99 (54%) fueron masculinos y 84 (46%) femeninos. La tasa de ITS asociadasa CVC fue 14.03 infecciones por 1 000 días uso CVC. Encontramos 24 casos de ITS asociadas a CVC. ElStaphylococcus coagulasa negativo fue el germen más frecuente (n=8), seguido de Candida albicans ( n=7).En el análisis de regresión logística, se encontraron los siguientes factores de riesgo: CVC múltiple (>1) ( p:0.030; RR: 3.2; 95% IC: 1.1 - 9.2) y sexo masculino (p: 0.013; RR: 3.1; 95% IC: 1.3 - 7.7).Conclusiones: Se identificó una alta tasa de ITS asociada a CVC. El sexo masculino y el CVC múltiple (>1)fueron factores de riesgo para ITS asociados a CVC. Es necesario un estudio prospectivo con mayor númerode pacientes para identificar otros factores de riesgo.
De forførte som oprørere
Authors: Tobias-Renstrøm Sebastian
Published: November 2023

“Nogen burde gøre noget!” Men hvorfor gør ingen egentligt det? En politisk motiveret psykologi bør være i stand til at forklare os, hvordan folk begynder at gøre oprør imod systemer, som de ikke finder tilfredsstillende, men også hvorfor de nogle gange ikke gør dette. I denne artikel vil jeg bruge begrebet om begær som en teoretisk prisme for at søge at forstå dette problem ved at stille spørgsmålet: hvordan får man folk til at ville oprøret? Dette udfoldes med eksemplet om psykologistuderende på Københavns Universitet, hvor jeg selv er uddannet fra, som bruges til at understøtte den teoretiske og begrebsmæssige udvikling.

Artiklen begynder med en indledende syntetisering af en begrebslig struktur, som skal tjene det formål at kunne forklare teoretisk, hvad det vil sige at begære noget, som indebærer et oprør – altså at ville det. Med udgangspunkt i Bernard Stieglers filosofi og Hartmut Rosas sociologi søges herefter at beskrive, hvordan begæret kan knægtes eller på anden måde omdirigeres, hvilket i en teoretisk for- stand kan gøre begæreret om oprøret umuligt. Det vil blive søgt demonstreret, at det er muligt at bekæmpe det system, der knægter begærsstrukturerne, igennem ideologikritikken som interpellation (Nissen, 2012). I artiklen bliver disse teorier videreudviklet ved at inddrage

begrebet om performance (Butler, 1988), som reatikuleres til en forførende praksis (Laplanche, 2011). Opsummerende argumenterer jeg i denne artikel for, at reartikulationen som gensidigt interpellerende praksis af forførelse kan muliggøre begæret af det, der indebærer oprøret, og der argumenteres ydermere for at sådanne et begær er nødvendigt for at et oprør kan finde sted. Der gives et bud på, hvordan sådan en reartikulation kan se ud vedrørende eksemplet med de psykologistuderende. Slut- teligt reflekteres der kort over, hvad der sker “dagen efter oprøret”.
Ideologia i estètica a una revista de l’exili, «Lletres» (1944-1948) d’Agustí Bartra
Authors: Ruiz Soriano Francesc
Published: November 2023

Les revistes catalanes de l’exili van jugar un paper important en la defensa de la llengua i la literatura de postguerra, entre les quals destaca la revista Lletres (1944-1948), creada per Agustí Bartra a Mèxic. L’article estudia les seves característiques, marcades per un vessant mític i simbòlic de la mà d’escriptors com Jordi Vallès, Pere Calders o Joan Roura-Parella que veia en l’art una projecció espiritual per a l’educació humana, trets de caire neoromàntic que influïren en l’estètica compromesa de Bartra. A més a més d’analitzar els antecedents de la publicació com el Full Català (1941-1942) i les polèmiques que hi va haver entre alguns dels col·laboradors, sobretot amb Joan Sales i Ferran de Pol, controvèrsia que continuaria a Quaderns de l’exili (1943-1947), s’estudia el nucli fundacional, els propòsits i el contingut dels números de la revista.
Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability
Authors: Lu Ke , Zhang Ming , Wei Guizheng , Xiao Guozhi , Tong Liping , Chen Di
Published: November 2023

Cyclin D1 is a key regulator of cell cycle progression, which forms a complex with CDK4/6 to regulate G1/S transition during cell cycle progression. Cyclin D1 has been recognized as an oncogene since it was upregulated in several different types of cancers. It is known that the post-translational regulation of cyclin D1 is controlled by ubiquitination/proteasome degradation system in a phosphorylation-dependent manner. Several cullin-associated F-box E3 ligases have been shown to regulate cyclin D1 degradation; however, it is not known if additional cullin-associated E3 ligases participate in the regulation of cyclin D1 protein stability. In this study, we have screened an siRNA library containing siRNAs specific for 154 ligase subunits, including F-box, SOCS, BTB-containing proteins, and DDB proteins. We found that multiple cullin-associated E3 ligases regulate cyclin D1 activity, including Keap1, DDB2, and WSB2. We found that these E3 ligases interact with cyclin D1, regulate cyclin D1 ubiquitination and proteasome degradation in a phosphorylation-dependent manner. These E3 ligases also control cell cycle progression and cell proliferation through regulation of cyclin D1 protein stability. Our study provides novel insights into the regulatory mechanisms of cyclin D1 protein stability and function.
Allosteric regulation of kinase activity in living cells
Authors: Godbole Shivani Sujay , Dokholyan Nikolay V
Published: November 2023

The dysregulation of protein kinases is associated with multiple diseases due to the kinases' involvement in a variety of cell signaling pathways. Manipulating protein kinase function, by controlling the active site, is a promising therapeutic and investigative strategy to mitigate and study diseases. Kinase active sites share structural similarities, making it difficult to specifically target one kinase, and allosteric control allows specific regulation and study of kinase function without directly targeting the active site. Allosteric sites are distal to the active site but coupled via a dynamic network of inter-atomic interactions between residues in the protein. Establishing an allosteric control over a kinase requires understanding the allosteric wiring of the protein. Computational techniques offer effective and inexpensive mapping of the allosteric sites on a protein. Here, we discuss the methods to map and regulate allosteric communications in proteins, and strategies to establish control over kinase functions in live cells and organisms. Protein molecules, or ‘sensors,’ are engineered to function as tools to control allosteric activity of the protein as these sensors have high spatiotemporal resolution and help in understanding cell phenotypes after immediate activation or inactivation of a kinase. Traditional methods used to study protein functions, such as knockout, knockdown, or mutation, cannot offer a sufficiently high spatiotemporal resolution. We discuss the modern repertoire of tools to regulate protein kinases as we enter a new era in deciphering cellular signaling and developing novel approaches to treat diseases associated with signal dysregulation.
Distractor effects in decision making are related to the individual’s style of integrating choice attributes
Authors: Wong Jing Jun , Bongioanni Alessandro , Rushworth Matthew FS , Chau Bolton KH
Published: November 2023

Humans make irrational decisions in the presence of irrelevant distractor options. There is little consensus on whether decision making is facilitated or impaired by the presence of a highly rewarding distractor, or whether the distractor effect operates at the level of options’ component attributes rather than at the level of their overall value. To reconcile different claims, we argue that it is important to consider the diversity of people’s styles of decision making and whether choice attributes are combined in an additive or multiplicative way. Employing a multi-laboratory dataset investigating the same experimental paradigm, we demonstrated that people used a mix of both approaches and the extent to which approach was used varied across individuals. Critically, we identified that this variability was correlated with the distractor effect during decision making. Individuals who tended to use a multiplicative approach to compute value, showed a positive distractor effect. In contrast, a negative distractor effect (divisive normalisation) was prominent in individuals tending towards an additive approach. Findings suggest that the distractor effect is related to how value is constructed, which in turn may be influenced by task and subject specificities. This concurs with recent behavioural and neuroscience findings that multiple distractor effects co-exist.
Looking for related posts on GitHub discussions
Authors: Lima Marcia , Steinmacher Igor , Ford Denae , Liu Evangeline , Vorreuter Grace , Conte Tayana , Gadelha Bruno
Published: November 2023

Software teams increasingly adopt different tools and communication channels to aid the software collaborative development model and coordinate tasks. Among such resources, software development forums have become widely used by developers. Such environments enable developers to get and share technical information quickly. In line with this trend, GitHub announced GitHub Discussions—a native forum to facilitate collaborative discussions between users and members of communities hosted on the platform. Since GitHub Discussions is a software development forum, it faces challenges similar to those faced by systems used for asynchronous communication, including the problems caused by related posts (duplicated and near-duplicated posts). These related posts can add noise to the platform and compromise project knowledge sharing. Hence, this article addresses the problem of detecting related posts on GitHub Discussions. To achieve this, we propose an approach based on a Sentence-BERT pre-trained general-purpose model: the RD-Detector. We evaluated RD-Detector using data from three communities hosted in GitHub. Our dataset comprises 16,048 discussion posts. Three maintainers and three Software Engineering (SE) researchers manually evaluated the RD-Detector results, achieving 77–100% of precision and 66% of recall. In addition, maintainers pointed out practical applications of the approach, such as providing knowledge to support merging the discussion posts and converting the posts to comments on other related posts. Maintainers can benefit from RD-Detector to address the labor-intensive task of manually detecting related posts.
Manipulating network connectance by altering plant attractiveness
Authors: Russo Laura , Stout Jane C.
Published: November 2023

Background

Mutualistic interactions between plants and their pollinating insects are critical to the maintenance of biodiversity. However, we have yet to demonstrate that we are able to manage the structural properties of these networks for the purposes of pollinator conservation and preserving functional outcomes, such as pollination services. Our objective was to explore the extent of our ability to experimentally increase, decrease, and maintain connectance, a structural attribute that reflects patterns of insect visitation and foraging preferences. Patterns of connectance relate to the stability and function of ecological networks.

Methods

We implemented a 2-year field experiment across eight sites in urban Dublin, Ireland, applying four agrochemical treatments to fixed communities of seven flowering plant species in a randomized block design. We spent ~117 h collecting 1,908 flower-visiting insects of 92 species or morphospecies with standardized sampling methods across the 2 years. We hypothesized that the fertilizer treatment would increase, herbicide decrease, and a combination of both maintain the connectance of the network, relative to a control treatment of just water.

Results

Our results showed that we were able to successfully increase network connectance with a fertilizer treatment, and maintain network connectance with a combination of fertilizer and herbicide. However, we were not successful in decreasing network connectance with the herbicide treatment. The increase in connectance in the fertilized treatment was due to an increased species richness of visiting insects, rather than changes to their abundance. We also demonstrated that this change was due to an increase in the realized proportion of insect visitor species rather than increased visitation by common, generalist species of floral visitors. Overall, this work suggests that connectance is an attribute of network structure that can be manipulated, with implications for management goals or conservation efforts in these mutualistic communities.
Expansión urbana más allá del límite urbano: un análisis de Santiago de Chile desde la planificación urbana y sus contradicciones normativas territoriales
Authors: Schuster-Olbrich Juan Pablo , Vich Guillem , Miralles-Guasch Carme
Published: November 2023

El crecimiento urbano de las metrópolis latinoamericanas ha adoptado diferentes patrones espaciales e intensidades; entre ellos, una forma urbana que se da en expansión y crece hacia fuera del núcleo de la ciudad. Para hacer frente a las consecuencias negativas de tal crecimiento, los Estados han establecido políticas destinadas a controlar y orientar el desarrollo urbano expansivo, principalmente a través de la planificación urbana y la regulación del suelo. Este estudio analiza el rol de la planificación y normativa urbana en la expansión de la ciudad de Santiago de Chile entre 1997 y 2013, utilizando para ello mapas de cobertura, la zonificación establecida por el Plan Regulador Metropolitano de Santiago y una revisión de la normativa aplicable. Se demuestra que la ciudad se expande en aquellas zonas declaradas como no urbanas por el Plan, proceso en que el Estado desempeña un rol activo al establecer normas que permiten expandir la ciudad, produciendo contradicciones normativas territoriales.
Information Sharing among Actors in Dairy Innovation Platforms
Authors: Jadhav Abhishek , Meena B. S. , Girish C. E.  , Meena H. R.
Published: November 2023

Dairy farming is a cornerstone of global food security, serving as a primary source of nutrition for a burgeoning world population. Information sharing, a fundamental practice of exchanging knowledge and data, plays a pivotal role in enhancing the dairy sector's productivity and sustainability. This study delves into the intricacies of information exchange within the context of dairy innovation platforms (IPs) dynamic collaborative spaces where diverse stakeholders, including farmers, researchers, input suppliers and extension personnels etc., converge to address common challenges. Taking place both physically and virtually, dairy IPs facilitates collective problem-solving, with each member contributing their unique expertise to foster a win-win collaborative environment. This research article draws from a comprehensive investigation conducted in Haryana (India), focusing on two districts with substantial bovine populations i.e., Karnal and Hisar. These districts are home to multiple agricultural research institutes, universities and innovation platforms actively engaged in the dairy sector. Data were gathered randomly from 140 dairy actors, that includes researchers, extension personnels, input suppliers and dairy farmers, all with a minimum of five years of experience in their respective fields. Information sharing was evaluated through responses to specific dairy-related topics such as breeding, feeding, healthcare and management practices, collected during March 2017. Our findings reveal a dynamic landscape of information sharing among different actors within the dairy innovation platform. Researchers emerge as key contributors to topics like animal breeding (27.87%) and extreme weather control, while extension personnel excel in areas like pregnancy diagnosis and disbudding. Dairy Farmers, constituting the largest group, exhibit a keen interest in concentrate composition and green fodder types. Dairy farming serves as a critical pillar in meeting the nutritional needs of our ever-expanding global population and the information sharing is fundamental to enhancing its productivity and sustainability.
In-vitro Pharmacological Investigation of Ludwigia adscendens
Authors: Bhuiyan Md. Anik , Shomudro Hasib Khan , Chowdhury Sadia Afreen
Published: November 2023

Aims: This research objective was to investigate some in-vitro properties of methanol-extracted plant extracts of Ludwigia adscendens (the water primrose). The primary method of assessment for the methanolic extract of Ludwigia adscendens (MELA) was investigated for phytochemical screening. It was determined to look into the plant's potential for in vitro activities, such as antioxidant, antimicrobial, anti-inflammatory anti-arthritis, cytotoxic, thrombolytic and membrane stabilizing activity due to the pharmaceutical interest in its component parts.

Methodology: Phytochemical screening was performed utilizing a battery of test reagents. Antioxidant, antimicrobial, anti-inflammatory, anti-arthritic, cytotoxic, thrombolytic and membrane stabilizing activities were measured at various doses using the DPPH Free Radical Scavenging Assay, the Disk Diffusion Method, Egg Albumin Protein Denaturation Assay, the Inhibition of Protein Denaturation Assay, the Brine Shrimp Lethality Bioassay, Clot lysis assay and heat induced and hypotonic induced haemolysis method.

Results: The findings of research on MELA's phytochemical screening showed the presence of a wide range of various phytochemical components. The higher antioxidant activity of MELA is shown by its IC50 value of 85.76 µg/mL. Significant antibacterial action was shown by MELA. As compared to the standard ascorbic acid, this extract showed significantly greater anti-arthritic and anti-inflammatory effects. MELA exhibited much higher LC50 value which is 1.147 µg/mL than the typical vincristine-sulphate in a lethality test with brine shrimp. Comparatively speaking, this herb has quite powerful thrombolytic action. Significant membrane stabilizing action has also been shown by MELA.

Conclusion: To wrap it up, it is clear that this plants phytochemical can be used for wide range of drug discovery field due to its potent pharmacological actions.