bluuebunny/crossref_metadata_2025 huggingface dataset:
Why hydroxy-proline improves the catalytic power of the peptidoglycan N-deacetylase enzyme: insight from theory
Authors: Prejanò Mario , Romeo Isabella , Sgrizzi Luigi , Russo Nino , Marino Tiziana
Published: October 2019

The OH moiety of 2Hyp establishes a larger H-bond network and an electrostatic environment that stabilizes the transition state, reducing the related energy demand.
Combined co-solvent and pressure effect on kinetics of a peptide hydrolysis: an activity-based approach
Authors: Knierbein Michael , Wangler Anton , Luong Trung Quan , Winter Roland , Held Christoph , Sadowski Gabriele
Published: October 2019

An activity-based approach to predict combined influence of pressure and co-solvent on enzymatic reaction kinetics is presented.
Conformational preference determined by inequivalent n-pairs: rotational studies on acetophenone and its monohydrate
Authors: Lei Juncheng , Zhang Jiaqi , Feng Gang , Grabow Jens-Uwe , Gou Qian
Published: October 2019

Acetophenone and its complex with water have been investigated by using pulsed jet Fourier transform microwave spectroscopy complemented with quantum chemical calculations.
Polymer spacer tunable Purcell-enhanced spontaneous emission in perovskite quantum dots coupled to plasmonic nanowire networks
Authors: Li Hanmei , He Futao , Ji Chuankun , Zhu Weiwei , Xu Yuanqing , Zhang Wenkai , Meng Xianrui , Fang Xiaomin , Ding Tao
Published: October 2019

Bright and fast emission of perovskite quantum dots has been demonstrated by using a polymer spacer to regulate the exciton–plasmon coupling.
UV absorption spectra of DNA bases in the 350–190 nm range: assignment and state specific analysis of solvation effects
Authors: Sapunar Marin , Domcke Wolfgang , Došlić Nađa
Published: October 2019

The theoretical assignment of electronic spectra of polyatomic molecules is a challenging problem that requires the specification of the character of a large number of electronic states.
A multi-layer energy-based fragment method for excited states and nonadiabatic dynamics
Authors: Chen Wen-Kai , Fang Wei-Hai , Cui Ganglong
Published: October 2019

We developed a multi-layer energy-based fragment (MLEBF) method within the many-body energy expansion framework.
Coordination complexes involving sydnones as ligands
Authors: Bantreil Xavier , Pétry Nicolas , Lamaty Frédéric
Published: October 2019

Coordination complexes featuring sydnones as ligands, despite their rarity, show great potential for future applications.
Influence of organic cation planarity on structural templating in hybrid metal-halides
Authors: Oswald Iain W. H. , Ahn Hyochul , Neilson James R.
Published: October 2019

The structure and planarity of aromatic organic cations directly influence both the inorganic connectivity and the resulting optical properties of hybrid semiconductors, thus providing tunability for optoelectronic applications.
Advances in sodium secondary batteries utilizing ionic liquid electrolytes
Authors: Matsumoto Kazuhiko , Hwang Jinkwang , Kaushik Shubham , Chen Chih-Yao , Hagiwara Rika
Published: October 2019

This review summarizes the use of ionic liquids in Na secondary batteries and discusses their electrochemical performance with various electrode materials.
Faradaic electro-swing reactive adsorption for CO2 capture
Authors: Voskian Sahag , Hatton T. Alan
Published: October 2019

Novel parallel passage adsorption system allows the electrochemical toggling of CO2 affinity for highly selective efficient carbon capture.
Single-particle ICP-TOFMS with online microdroplet calibration for the simultaneous quantification of diverse nanoparticles in complex matrices
Authors: Mehrabi Kamyar , Günther Detlef , Gundlach-Graham Alexander
Published: October 2019

Online microdroplet calibration is used to determine the mass and particle number concentration of inorganic nanoparticles (NPs) without the use of NP standards. This approach can be applied directly to quantify NPs in environmental matrices.
Status and challenges in photocatalytic nanotechnology for cleaning air polluted with volatile organic compounds: visible light utilization and catalyst deactivation
Authors: Weon Seunghyun , He Fei , Choi Wonyong
Published: October 2019

Photocatalysis that utilizes semiconductor nanoparticles is one of the promising environmental technology for air purification.
Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds
Authors: Yang Tonghao , Lin Yajun , Yang Chaoqun , Yu Wei
Published: October 2019

Synthesis of enamides via 1,2-acyl migration of tertiary α-azido ketones was accomplished efficiently by the catalysis of FeBr2 and Et3N.
Unravelling the mechanism of water sensing by the Mg2+ dihydroxy-terephthalate MOF (AEMOF-1′)
Authors: Papazoi Eleutheria , Douvali Antigoni , Diamantis Stavros A. , Papaefstathiou Giannis S. , Eliseeva Svetlana V. , Petoud Stéphane , Hatzidimitriou Antonios G. , Lazarides Theodore , Manos Manolis J.
Published: October 2019

The amorphous compound [Mg(H2dhtp)(H2O)2] 1′ was shown to be a highly efficient and reusable luminescent sensor for the detection of water in THF, due to its transformation to the strongly emissive complex [Mg(H2dhtp)(H2O)5]·H2O 1.
Evidence of a strong perpendicular magnetic anisotropy in Au/Co/MgO/GaN heterostructures
Authors: Gao Xue , Yang Baishun , Devaux Xavier , Yang Hongxin , Liu Jianping , Liang Shiheng , Stoffel Mathieu , Pasquier Ludovic , Hyot Bérangère , Grenier Adeline , Bernier Nicolas , Migot Sylvie , Mangin Stéphane , Rinnert Hervé , Jiang Chunping , Zeng Zhongming , Tang Ning , Sun Qian , Ding Sunan , Yang Hui , Lu Yuan
Published: October 2019

We demonstrate that a 4.6 nm thick Co film grown on MgO/GaN still exhibits a large perpendicular magnetic anisotropy.
Tuning magnetic anisotropy in Co–BaZrO3 vertically aligned nanocomposites for memory device integration
Authors: Zhang Bruce , Huang Jijie , Jian Jie , Rutherford Bethany X. , Li Leigang , Misra Shikhar , Sun Xing , Wang Haiyan
Published: October 2019

Ferromagnetic nanostructures with tunable, strong anisotropic properties are highly desired for their potential integration into spintronic devices.
A photo-crosslinked hybrid interpenetrating polymer network (IPN) for antibacterial coatings on denture base materials
Authors: Cheng Qiuli , Guo Xiaowei , Zou Jiawei , Shi Xiaoyu , Ding Shuxiang , Shi Zuosen , Zhu Song , Cui Zhanchen
Published: October 2019

An interpenetrating polymer network (IPN) structured antibacterial layer was prepared on dental base materials using a one-step photo-crosslinking method.
Constitutional isomers of dendrimer-like pyrene substituted cyclotriphosphazenes: synthesis, theoretical calculations, and use as fluorescence receptors for the detection of explosive nitroaromatics
Authors: Ardic Alidagi Husniye , Tümay Süreyya Oğuz , Şenocak Ahmet , Çiftbudak Ömer Faruk , Çoşut Bünyemin , Yeşilot Serkan
Published: October 2019

Two constitutionally isomeric bis-pyrenyl phenol dendrons (4and6) and their dendrimer-like cyclotriphosphazene derivatives (5and7) are designed, synthesized and fluorescence detection behaviors are evaluated for nitro aromatic compounds (NACs).
Lithium diisobutyl-tert-butoxyaluminum hydride (LDBBA) catalyzed hydroboration of alkynes and imines with pinacolborane
Authors: Jaladi Ashok Kumar , Kim Hanbi , Lee Ji Hye , Shin Won Kyu , Hwang Hyonseok , An Duk Keun
Published: October 2019

Lithium diisobutyl-tert-butoxyaluminum hydride (LDBBA) catalyzed hydroboration of alkynes and imines with pinacolborane (HBpin) was demonstrated.
Molybdenum carbide as an efficient and durable catalyst for aqueous Knoevenagel condensation
Authors: Tavakolian Mina , Najafpour Mohammad Mahdi
Published: October 2019

Molybdenum carbide showed an efficient performance for the Knoevenagel condensation in aqueous media at room temperature, affording the corresponding products in high yields within a short reaction time.
Protein-coated dsDNA nanostars with high structural rigidity and high enzymatic and thermal stability
Authors: Sanchez-Rueda Eddie G. , Rodriguez-Cristobal Estefani , Moctezuma González Claudia L. , Hernandez-Garcia Armando
Published: October 2019

This study presents a strategy to prepare a novel building block, a structurally defined large hybrid protein–dsDNA nanostar, through self-assembly of PCR-made dsDNA fragments with a DNA junction, and its later coating with a DNA binding protein.
Probing the dynamic evolution of lithium dendrites: a review ofin situ/operandocharacterization for lithium metallic batteries
Authors: Ma Yue , Li Shaowen , Wei Bingqing
Published: October 2019

During the operation of lithium metal batteries, the direct observation of the evolving characteristics of the deposited lithium is rather challenging in consideration of the requirements for the fast-tracking and high spatial resolution of the signals within native organic electrolytes.
Influence of Zn and Co co-doping on oxygen evolution reaction electrocatalysis at MOF-derived N-doped carbon electrodes
Authors: Yang Xiaobing , Chen Juan , Yang Weishen , Lin Hao , Luo Xuetao
Published: October 2019

Schematic illustration of the synthesis of the Zn1−xCox/NC catalyst.
Electro-activity and magnetic switching in lanthanide-based single-molecule magnets
Authors: Cador Olivier , Le Guennic Boris , Pointillart Fabrice
Published: October 2019

The present work reviews switching of single-molecule magnetic behaviour achieved through various stimuli such as temperature, light irradiation, redox processes, solvation/desolvation, and magnetic field.
Various magnetic states for novel layered cobalt oxides CaCo6O11and BaCo6O11
Authors: Yamada Ikuya , Toda Fumito , Kawaguchi Shogo , d'Astuto Matteo
Published: October 2019

Various magnetic states have been discovered in novel layered cobalt oxides CaCo6O11and BaCo6O11.
Ring-opening/annulation reaction of cyclopropyl ethanols: concise access to thiophene aldehydes via C–S bond formation
Authors: Wang Ting , An Zhenyu , Qi Zhenjie , Zhuang Daijiao , Chang Aosheng , Yang Yunxia , Yan Rulong
Published: October 2019

The synthesis of thiophene aldehydes from easily available cyclopropyl ethanol derivatives and potassium sulfide has been developed.
The inverted solvatochromism of protonated ferrocenylethenyl-pyrimidines: the first example of the solvatochromic reversal of a hybrid organic/inorganic dye
Authors: Vidal Matías , Pastenes Camila , Rezende Marcos Caroli , Aliaga Carolina , Domínguez Moisés
Published: October 2019

Five new solvatochromic 2,6-diaryl-4-ferrocenylethenylpyrimidines were synthesized and their spectral variations in solution investigated in twenty-seven solvents of variable polarity.
Tuning the optical properties of spiro-centered charge-transfer dyes by extending the donor or acceptor part
Authors: Wössner Jan S. , Grenz David C. , Kratzert Daniel , Esser Birgit
Published: October 2019

Spiroconjugated charge-transfer dyes with N–CO-substructure are presented, whose optical properties are tuned by extending the donor or acceptor part.
Core-modified 48π and 42π decaphyrins: syntheses, properties and structures
Authors: Ghosh Arindam , Dash Syamasrit , Srinivasan A. , Suresh C. H. , Peruncheralathan S. , Chandrashekar Tavarekere K.
Published: October 2019

Protonation triggered transition of a 48π nonaromatic decaphyrin to a 48π Hückel antiaromatic decaphyrin is reported: the flexibility of the macrocycle due to the presence of twelve meso carbon bridges facilitates such a transition through conformational change.
A new way for lead–boron resin composite modification: SiO2 coated lead powders by a sol–gel method
Authors: Ma Lingcheng , Liu Ying , Li Jun , Jin Na , Li Cheng , Zhou Xue , Ma Jiaxu
Published: October 2019

The core–shell SiO2@Pb powders were prepared to improve the physical properties of composites.
Electrospun Janus-like pellicle displays coinstantaneous tri-function of aeolotropic conduction, magnetism and luminescence
Authors: Xie Yunrui , Ma Qianli , Qi Haina , Song Yan , Tian Jiao , Musa Makiyyu Abdullahi , Yu Wensheng , Dong Xiangting , Li Dan , Liu Guixia
Published: October 2019

Janus-like pellicle with conductive aeolotropism, magnetism and luminescence is designed and constructedviaelectrospinning by combining microcosmic with macroscopic partitions.
Correction: Bio-conjugation of graphene quantum dots for targeting imaging
Authors: Jia Fei , Lv Shuyu , Xu Sha
Published: October 2019

Correction for ‘Bio-conjugation of graphene quantum dots for targeting imaging’ by Fei Jia et al., RSC Adv., 2017, 7, 53532–53536.
Well-distributed Pt-nanoparticles within confined coordination interspaces of self-sensitized porphyrin metal–organic frameworks: synergistic effect boosting highly efficient photocatalytic hydrogen evolution reaction
Authors: Li Shuai , Mei Hong-Min , Yao Shi-Lin , Chen Zhi-Yao , Lu Yu-Lin , Zhang Li , Su Cheng-Yong
Published: October 2019

An effective strategy for the fabrication of an efficient HER photocatalyst of Pt@Pd-PCN222(Hf) has been reported.
Correction: Rapid room temperature synthesis of red iridium(iii) complexes containing a four-membered Ir–S–C–S chelating ring for highly efficient OLEDs with EQE over 30%
Authors: Lu Guang-Zhao , Su Ning , Yang Hui-Qing , Zhu Qi , Zhang Wen-Wei , Zheng You-Xuan , Zhou Liang , Zuo Jing-Lin , Chen Zhao-Xu , Zhang Hong-Jie
Published: October 2019

Correction for ‘Rapid room temperature synthesis of red iridium(iii) complexes containing a four-membered Ir–S–C–S chelating ring for highly efficient OLEDs with EQE over 30%’ by Guang-Zhao Lu et al., Chem. Sci., 2019, 10, 3535–3542.
Dye-sensitized solar cells using fluorone-based ionic liquids with improved cell efficiency
Authors: Pinto Ana L. , Parola A. Jorge , Leal João P. , Coutinho Isabel B. , Pereira Cláudia C. L.
Published: October 2019

TiO2 and [P6,6,6,14]2 fluorone highly hydrophobic ionic liquid dye.
Bubbles nucleating on superhydrophobic micropillar arrays under flow
Authors: Pinchasik Bat-El , Schönfeld Friedhelm , Kappl Michael , Butt Hans-Jürgen
Published: October 2019

When a supersaturated aqueous solution flows over a microstructured, hydrophobic surface, bubbles tend to nucleate. Here, we control heterogeneous nucleation of gas bubbles from supersaturated CO2 solution.
Enhancement of the anisotropic thermoelectric power factor of topological crystalline insulator SnTe and related alloys via external perturbations
Authors: Yarmohammadi Mohsen , Mirabbaszadeh Kavoos
Published: October 2019

The ability to fine-tune the linearly dispersed metallic surface state in TCIs is highly desirable for thermoelectric applications.
Activating and optimizing the activity of NiCoP nanosheets for electrocatalytic alkaline water splitting through the V doping effect enhanced by P vacancies
Authors: Yan Yaotian , Lin Jinghuang , Cao Jian , Guo Shu , Zheng Xiaohang , Feng Jicai , Qi Junlei
Published: October 2019

We design V doped NiCoP nanosheets with P vacancies induced by Ar plasma as a cost-effective and bifunctional electrocatalyst for overall water splitting.
Geometrically customizable alginate hydrogel nanofibers for cell culture platforms
Authors: Fujita Satoshi , Wakuda Yuka , Matsumura Minori , Suye Shin-ichiro
Published: October 2019

Hydrogel nanofibers derived from alginate with an anisotropic structure fabricated by using core–shell electrospinning play an important role in cell adhesion and proliferation as the extracellular matrix (ECM).
A fluorescent probe for simultaneously sensing NTR and hNQO1 and distinguishing cancer cells
Authors: Kong Fanpeng , Li Ying , Yang Chao , Li Xiao , Wu Junlin , Liu Xiaojun , Gao Xiaonan , Xu Kehua , Tang Bo
Published: October 2019

A dual-enzyme-responsive probe, CNN, was rationally designed and synthesized for differentiating cancer cells from normal cells owing to the existence of relatively high endogenous levels of both biomarkers in cancer cells.
Healing kinetics of diabetic wounds controlled with charge-biased hydrogel dressings
Authors: Venault Antoine , Bai Yu-Wen , Dizon Gian Vincent , Chou Han-Yi Elizabeth , Chiang Heng-Chieh , Lo Chen-Tsyr , Zheng Jie , Aimar Pierre , Chang Yung
Published: October 2019

This study investigates the properties and use as wound-dressings of hydrogels made of anionic 3-sulfopropyl methacrylate (SA) and cationic [2-(methacryloyloxy)ethyl]trimethylammonium (TMA) to form poly(SA-co-TMA) gels with varying charge bias.
Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes
Authors: Ma Dik-Lung , Wu Chun , Liu Hao , Wu Ke-Jia , Leung Chung-Hang
Published: October 2019

Abnormally expressed receptor proteins are proved to be one of the crucial biomarkers for specific human diseases. Transitional metal based strategies possess delightful strengths in the in-field and real-time visualization of receptor proteins.
Near infrared emitting quantum dots: synthesis, luminescence properties and applications
Authors: Ma Yue , Zhang Yu , Yu William W.
Published: October 2019

Near-infrared QDs and their applications.
Precipitating CsPbBr3 quantum dots in boro-germanate glass with a dense structure and inert environment toward highly stable and efficient narrow-band green emitters for wide-color-gamut liquid crystal displays
Authors: Pang Xiaoliang , Zhang Haoran , Xie Liqing , Xuan Tongtong , Sun Yuqiong , Si Shuaichen , Jiang Bin , Chen Weibin , Zhuang Jianle , Hu Chaofan , Liu Yingliang , Lei Bingfu , Zhang Xuejie
Published: October 2019

CsPbBr3 QDs were successfully precipitated in specially designed boro-germanate glass with super optical properties and improved stability for wide-color-gamut displays.
Exploring the conditions for forming cold gas giants through planetesimal accretion
Authors: Johansen Anders , Bitsch Bertram
Published: October 2019

The formation of cold gas giants similar to Jupiter and Saturn in orbit and mass is a great challenge for planetesimal-driven core accretion models because the core growth rates far from the star are low. Here we model the growth and migration of single protoplanets that accrete planetesimals and gas. We integrated the core growth rate using fits in the literature to N-body simulations, which provide the efficiency of accreting the planetesimals that a protoplanet migrates through. We take into account three constraints from the solar system and from protoplanetary discs: (1) the masses of the terrestrial planets and the comet reservoirs in Neptune’s scattered disc and the Oort cloud are consistent with a primordial planetesimal population of a few Earth masses per AU, (2) evidence from the asteroid belt and the Kuiper belt indicates that the characteristic planetesimal diameter is 100 km, and (3) observations of protoplanetary discs indicate that the dust is stirred by weak turbulence; this gas turbulence also excites the inclinations of planetesimals. Our nominal model built on these constraints results in maximum protoplanet masses of 0.1 Earth masses. Ignoring constraint (1) above, we show that even a planetesimal population of 1000 Earth masses, corresponding to 50 Earth masses per AU, fails to produce cold gas giants (although it successfully forms hot and warm gas giants). We conclude that a massive planetesimal reservoir is in itself insufficient to produce cold gas giants. The formation of cold gas giants by planetesimal accretion additionally requires that planetesimals are small and that the turbulent stirring is very weak, thereby violating all three above constraints.
Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigmEpistemology of the origin of cancer”
Authors: Brücher Björn L.D.M. , Jamall Ijaz S.
Published: October 2019

It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect. Here, decades of thinking based on incorrect assumptions has resulted in an incorrect hypothesis on the origin of cancer. Many papers studying DNA, genetics, RNA, miRNA, proteomics, and epigenetics have increased our understanding of biology. Our paradigm, though more complex, is more reliable and plausible. It states that cancer originates from a disruption of homeostasis. This essential biological phenomenon, homeostasis, maintains the interrelationships of various signaling pathways and induced crosstalk which modify cellular functions together with the interactions of surrounding cells and structures such that the equilibrium lies towards the optimal health of the organism. This Special Issue “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer” provides compelling evidence that carcinogenesis is explained by a six-step sequence of events for the vast majority of cancers. These six steps include, (1) a pathogenic stimulus followed by (2) chronic inflammation, from which develops (3) fibrosis with associated remodeling in the cellular microenvironment. From these changes a (4) pre-cancerous niche develops which triggers the deployment of (5) a chronic stress escape strategy, and when this fails to resolve, and (6) the transition of a normal cell to a cancer cell occurs. This paradigm provides opportunities to move away from a symptom-oriented understanding of cancer and is much closer to a cause-based understanding, which opens the door for early preventative strategies to mitigate cancer as a disease, and to interdict metastases. This is underpinned by the fact that an independent recently published proof of this paradigm showed how a stimulus trigger the proposed multi-sequence cascade of events as abrupt involution-induced chronic inflammation, followed by fibrosis with remodeling, which describes the pre-cancerous niche followed by hyperplasia, metaplasia, and cancer.
Preservation technology investment, trade credit and partial backordering model for a non-instantaneous deteriorating inventory
Authors: Hashan Md Mashud Abu , Wee Hui-Ming , Huang Chiao-Ven
Published: October 2019

In a perfectly transparent and competitive market, suppliers must provide a competitive pricing and service for their customers. The aim of this study is to provide an insight into how preservation technology and credit financing could be used both to reduce the deterioration rate as well as to provide flexible financing for retailers. The methodology is to optimize the cycle length, selling price, the amount of preservation technology and credit financing using inventory theory. The result derived is an optimal total profit per unit time for the system. Finally, using MATLAB 2017a, it is shown graphically that the profit function is concave. The sensitivity analysis is illustrated using Lingo 17. The study not only provides insights to business managers in making wise managerial decisions, it also enables them to weigh the pro and con of implementing preservation technology and credit financing.
Overall outcomes of laparoscopic-assisted ERCP after Roux-en-Y gastric bypass and sphincter of Oddi dysfunction subgroup analysis
Authors: May David , Vogels Ellen , Parker David , Petrick Anthony , Diehl David , Gabrielsen Jon
Published: October 2019

Background and study aims Biliary access following Roux-en-Y gastric bypass (RYGB) anatomy presents a significant challenge. Long-term outcomes of laparoscopic-assisted trans-gastric ERCP (LA-ERCP) including sphincter of Oddi dysfunction (SOD) subtypes have not been thoroughly examined. Our study aims to present our overall outcomes of trans-gastric LAERCP and examine a significant subgroup of patients with SOD after RYGB.

Patients and methods A retrospective review of RYGB patients who underwent LA-ERCP between 2009 and 2016 identified 51 patients. A subgroup of 22 patients with SOD were examined and contacted by phone survey to determine long-term symptom resolution.

Results Post-procedure length of stay was 1.9 days (SD 3.0). There was one conversion from laparoscopic to open procedure. Selective cannulation rate was 100 %. Mean follow-up was 14.6 months. There were two major operative complications, two major ERCP-related complications, and five wound infections (9.8 %). No deaths or episodes of pancreatitis occurred. Seventeen patients had biliary SOD (Type I = 9, Type II = 8). The remaining four had pancreatic SOD (Type I = 1, Type II = 4). SOD subgroup follow-up was 21.4 months (SD 18.1). All patients with Type I biliary and 75 % with Type I pancreatic SOD reported complete resolution of their symptoms.

Conclusions Consistent with other published series, LA-ERCP yields excellent cannulation rates after RYGB. Successful treatment of pancreatic and Type 1 biliary SOD suggests that there is significant symptomatic benefit to treating this patient population. However, an overall complication rate of approximately 15 % with LAERCP leaves open the possibility for improvements in access techniques in post-RYGB patients.
A prospective randomized study of colonoscopy using blue laser imaging and white light imaging in detection and differentiation of colonic polyps
Authors: Ang Tiing Leong , Li James Weiquan , Wong Yu Jen , Tan Yi-Lyn Jessica , Fock Kwong Ming , Tan Malcolm Teck Kiang , Kwek Andrew Boon Eu , Teo Eng Kiong , Ang Daphne Shih-Wen , Wang Lai Mun
Published: October 2019

Background and study aims Published data on blue laser imaging (BLI) for detection and differentiation of colonic polyps are limited compared to narrow band imaging (NBI). This study investigated whether BLI can increase the detection rate of colonic polyps and adenomas when compared to white light imaging (WLI), and examined use of NICE (NBI International Colorectal Endoscopic) and JNET (Japan NBI Expert Team) classifications with BLI.

Patients and methods Patients aged 50 years and above referred for colonoscopy were randomized to BLI or WLI on withdrawal. Detected polyps were characterized using NICE and JNET classifications under BLI mode and correlated with histology. Primary outcome was adenoma detection rate. Secondary outcomes were utility of NICE and JNET classifications to predict histology using BLI.

Results A total of 182 patients were randomized to BLI (92) or WLI (90). Comparing BLI with WLI, the polyp detection rate was 59.8 % vs 40.0 %, P = 0.008, and the adenoma detection rate was 46.2 % vs 27.8 %, P = 0.010. NICE 1 and JNET 1 diagnosed hyperplastic polyps with sensitivity of 87.18 % and specificity of 84.35 %. NICE 2 diagnosed low- (LGD) or high-grade dysplasia (HGD) with sensitivity of 92.31 % and specificity of 77.45 %. JNET 2A diagnosed LGD with sensitivity of 91.95 %, and specificity of 74.53 %. Four cases of focal HGD all had JNET 2A morphology.

Conclusion BLI increased adenoma detection rate compared to WLI. NICE and JNET classifications can be applied when using BLI for endoscopic diagnosis of HP and LGD but histological confirmation remains crucial.
Rekonstruktion der brandverletzten Hand
Authors: Plock Jan , Calcagni Maurizio
Published: October 2019

Die Rekonstruktion der brandverletzten Hand erfordert detailliertes Spezialwissen
und chirurgisch-technische Fertigkeiten, um durch vorausschauende Planung ein
optimales Therapiekonzept aufstellen und ein optimales funktionelles Resultat
erreichen zu können. Der Einsatz eines breiten auf die Bedürfnisse der Situation
und der Patienten abgestimmten Armamentariums der plastischen Chirurgie und
Handchirurgie trägt dabei wesentlich zum Erfolg bei.

In dieser Übersicht gehen wir auf grundlegende Prinzipien, den zeitlichen Ablauf
der Rekonstruktion, die Einteilung der Deformitäten und entsprechende
Korrekturmöglichkeiten ein.
Welche PatientInnen sind mit dem Ergebnis ihrer sozialmedizinischen Leistungsbeurteilung nicht einverstanden und welche Behandlung brauchen sie?
Authors: Kessemeier Franziska Maria , Bassler Markus , Petermann Franz , Kobelt-Pönicke Axel
Published: October 2019

Fragestellung Die sozialmedizinische Leistungsbeurteilung ist zentraler Bestandteil des Entlassungsberichts der medizinischen Rehabilitation und stellt die Basis weiterer wichtiger versicherungsrechtlicher Maßnahmen dar. Immer wieder sind PatientInnen mit dem Ergebnis ihrer sozialmedizinischen Leistungsbeurteilung nicht einverstanden. Diese Tatsache verkompliziert häufig den Return to Work. Untersucht wird, ob sich diese Patientengruppen hinsichtlich soziodemografischer Parameter, der Bewertung der therapeutischen Allianz und des Reha-Outcome unterscheiden.

Material und Methoden KlinikmitarbeiterInnen werden dazu angehalten im Entlassungsbericht zu dokumentieren, ob ein Dissens bzgl. der sozialmedizinischen Leistungsbeurteilung vorliegt. Die Entlassungsberichte aller 2014 im Rehazentrum Oberharz behandelten PatientInnen wurden daraufhin gesichtet (n=1178). Mittels Chi-Quadrat-Tests und (multivariaten) Kovarianzanalysen wurden die Patientengruppen hinsichtlich soziodemographischer Parameter, Behandlungszufriedenheit, therapeutischer Allianz und psychosomatischen Veränderungen über die Rehabilitation analysiert.

Ergebnisse PatientInnen im Dissens konnten auf Symptomebene von ihrer Reha-Behandlung weniger profitieren, waren mit dem Ergebnis ihrer Behandlung und mit der Therapeut-Patient-Interaktion unzufriedener.

Diskussion Die sozialmedizinische Leistungsbeurteilung ist ein komplexer Prozess, der sowohl auf Beurteiler- wie auf Patientenseite durch zahlreiche Motive beeinflusst wird. Diese sind nur schwer zu erfassen und statistisch zu berücksichtigen.

Schlussfolgerungen Um durch den Dissens entstehende Komplikationen zu vermeiden, sollten insbesondere bei stark psychosomatisch belasteten PatientInnen mit problematischer Erwerbsbiografie früh berufsbezogene Therapieangebote eingeleitet werden. In der Therapie sozialmedizinisch auffälliger PatientInnen sollte ein besonderer Wert auf eine gute Patient-Therapeut-Passung gelegt werden.
Melanin Production Inhibitors from the West African Cassipourea congoensis
Authors: Takou Dieudonné M. , Waffo Alain F. Kamdem , Langat Moses K. , Wansi Jean D. , Mulcahy-Ryan Lauren E. , Schwikkard Sianne L. , Opara Elizabeth I. , Mas-Claret Eduard , Mulholland Dulcie A.
Published: October 2019

Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methylenecycloartan-30-oic acid 1 and 24-methylenecycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6
, (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 µM with low cytotoxicity validating the ethnomedicinal use of this plant.
DNVF-Memorandum – Gesundheits- und Medizin-Apps (GuMAs)
Authors: Kramer Ursula , Borges Uirassu , Fischer Florian , Hoffmann Wolfgang , Pobiruchin Monika , Vollmar Horst Christian
Published: October 2019

Mit der Nutzung von Gesundheits- und Medizin-Apps sind große Erwartungen an eine Verbesserung der Qualität und Effizienz von Präventions- und Versorgungskonzepten verknüpft. In weiten Bevölkerungsschichten ist die Bereitschaft zur Nutzung groß. Es fehlt jedoch belastbare Evidenz, um ausgehend vom derzeitigen, weitgehend unregulierten Angebot, Bedarf, Qualität und Sicherheit dieser Anwendungen einschätzen zu können. Aus diesem Grund adressiert die AG Digital Health im vorliegenden Memorandum wichtige Fragestellungen wie Angebot, objektiven Bedarf und Nettonutzen von Gesundheits- und Medizin-Apps (GuMAs), ethische Standards, Risiken und GuMAs als Forschungsressource, die von der Versorgungsforschung u. a. durch geeignete methodische Ansätze untersucht und beantwortet werden sollten. Diese Fragestellungen beziehen sich auf die Aspekte Patientensicherheit, Prozess- und Ergebnisqualität, versorgungsrelevante Aspekte digitaler Anwendungen und deren Einsatz in und für die wissenschaftliche Forschung.
New Synthesis of a Dibenzoperylene Motif Featuring a Doubly Boron–Nitrogen-Doped Bay Region
Authors: Fingerle Michael , Stocker Simon , Bettinger Holger F.
Published: October 2019

A dibenzoperylene motif featuring a doubly boron–nitrogen-doped bay region is accessible from an aniline derivative in six steps in good overall yield. Two n-butyl groups provide the BN-doped polycyclic aromatic hydrocarbon with sufficient solubility in common organic solvents. The synthesis sequence allows installation of a second boron atom next to a weakly nucleophilic nitrogen by using a protected boron species. The title compound shows blue fluorescence, an extremely high fluorescence quantum yield, and an interesting doped bay region.
The Bonding and Reactivity of α-Carbonyl Cyclopropanes
Authors: Craig Alexander J. , Hawkins Bill C.
Published: October 2019

The cyclopropane functionality has been exploited in a myriad of settings that range from total synthesis and methodological chemistry, to medical and materials science. While it has been seen in such a breadth of settings, the typical view of the cyclopropane moiety is that its reactivity is derived primarily from the release of ring strain. While this simplified view is a useful shorthand, it ignores the specific nature of cyclopropyl molecular orbitals. This review aims to present the different facets of cyclopropane bonding by examining the main models that have been used to explain the reactivity of the functionality over the years. However, even with advanced theory, being able to precisely predict the reactivity of an exact system is nigh impossible. Specifically chosen, carbonyl-bearing cyclopropyl species act as so-called acceptor cyclopropanes and, if correctly derivatised, donor–acceptor cyclopropanes. By undertaking a case study of the history of carbonyl cyclopropanes in organic synthesis, this review highlights the relationship between the understanding of theory and pattern recognition in developing new synthetic methods and showcases those successful in balancing this critical junction.

1 Cyclopropanes

2 The Strain Model

3 The Forster–Coulsin–Moffit Model

4 The Walsh Model

5 Acceptor, Donor, and Donor–Acceptor Cyclopropanes

6 Reactions of Carbonyl Cyclopropanes
Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a]pyrazines from α-Aminoacetonitriles
Authors: Karmakar Ananta , Ramalingam Sridharan , Basha Mushkin , Indasi Gopi Kumar , Belema Makonen , Meanwell Nicholas A. , Dhar T. G. Murali , Rampulla Richard , Mathur Arvind , Gupta Anuradha , Gupta Arun Kumar
Published: October 2019

An efficient and practical synthetic protocol for the synthesis of 1,4-disubstituted pyrrolo[1,2-a]pyrazine derivatives is described that originates from α-substituted pyrroloacetonitriles which, in turn, are readily available from aryl and alkyl aldehydes. The α-pyrroloacetonitriles were subjected to a Friedel–Crafts acylation with methyl chlorooxoacetate followed by reduction of the nitrile group under Pd-catalyzed hydrogenation conditions and finally aromatization with DDQ leading to the desired pyrrolo[1,2-a]pyrazine derivatives. This method was generalized and successfully applied to various aryl, heteroaryl, and alkyl substrates. The developed protocol provides direct and convenient access to 1,4-disubstituted ring systems in moderate to good overall yields (51–68%) without the need for purification of the intermediates. Further functionalization via the stepwise halogenation (bromination, iodination) and nitration was also demonstrated. In addition, the potential of the ester functionality for elaboration was demonstrated by manipulating into heterocyclic ring systems, exemplified by conversion into benzoxazole derivatives.
Localización con semilla radioactiva (LSR) de lesiones no palpables de la mama- Desarrollo e implementación del programa en la República Argentina
Authors: Muñoz María Soledad , Rossi Carlos Enrique , Muñoz Marcelo
Published: October 2019

El intervencionismo en mama se inició con la localización preoperatoria de lesiones no palpables.

En una segunda etapa, el desarrollo de técnicas de biopsias en las tres modalidades (mamografía, ultrasonido y resonancia magnética), reforzaron las indicaciones de localización de lesiones con histología ya confirmada.

La técnica de localización en Argentina se basó casi exclusivamente en la inserción de alambres con arpones e inyección de carbón.

A partir del año 2001, se ofreció como alternativa a las localizaciones con arpones la inserción de semilla de Iodo-125, considerando las ventajas para la paciente, el cirujano y el sistema hospitalario al desacoplar los turnos de quirófano y servicios de imágenes, otorgando acceso a cualquier cuadrante con incisiones cosméticas.

La provisión del isótopo es la clave para instalar y atender la demanda de los usuarios, una vez que han conocido los méritos del procedimiento.

En todos los ámbitos y distintos países, se verificó una lenta incorporación a la rutina de localización de lesiones con material radioactivo, primariamente por las regulaciones fundamentales y justificadas para la adquisición del isótopo.

En nuestro medio y en una labor conjunta con la Autoridad Regulatoria Nuclear (ARN), logramos finalmente, en el año 2017, el reconocimiento de la práctica.

Revisamos la bibliografía, describimos la técnica y la logística para lograr autorización de aquellos centros interesados en aplicar un procedimiento universalmente adoptado por sus ventajas respecto a los métodos tradicionales.
Implant-Retained Auricular Prosthesis: A Case Report
Authors: Ozturk A Nilgun , Usumez Aslihan , Tosun Zekeriya
Published: October 2019

Extraoral implant retained prosthesis have been proven to be a predictable treatment option for maxillofacial rehabilitation. This case report describes the clinical and laboratory procedures for fabricating an auricular prosthesis.

In this case report, an auricular prosthesis was fabricated for a patient who lost the left and right external ear in an electrical burn. Extraoral implants and bar-and-clip retention for the proper connection of the auricular prosthesis to implant were used. This prosthesis was acceptable to the patient because of excellent support, retentive abilities and the patient�s appearance. (Eur J Dent 2010;4:71-74)
Surgical Management of Chiari Malformations: Preliminary Results of Surgery According to the Mechanisms of Ptosis of the Brain Stem and Cerebellum
Authors: Nishikawa Misao , Bolognese Paolo A. , Kula Roger W. , Ikuno Hiromichi , Takami Toshihiro , Ohata Kenji
Published: October 2019

Introduction We classified Chiari malformation type I (CM-I) according to the mechanism of ptosis of the brain stem and cerebellum, based on a morphometric study of the posterior cranial fossa (PCF) and craniovertebral junction (CVJ). Surgery was performed to manage the mechanism of the hindbrain ptosis.

Materials and Methods We calculated the volume of the PCF (VPCF) and the area surrounding the foramen magnum (VSFM) and measured the axial length of the enchondral parts of the occipital bone (occipital bone size) and the hindbrain. According to these measures, we classified CM-I into type A (normal VPCF, normal VSFM, and normal occipital bone size), type B (normal VPCF, small VSFM, and small occipital bone size), and type C (small VPCF, small VSFM, and small occipital bone size). Foramen magnum decompression (FMD) (280 cases) was performed on CM-I types A and B. Expansive suboccipital cranioplasty (ESCP) was performed on CM-I type C. Posterior craniocervical fixation (CCF) was performed in cases with CVJ instability. Lysis of the adhesion and/or sectioning of the filum terminale were performed on cases with tethered cord syndrome.

Results Both ESCP and FMD had a high rate of improvement of neurological symptoms (87%) and recovery rate. There was only small number of complications. CCF had a high rate of improvement of neurological symptoms (88%) and joint stabilization.

Conclusion In the management of Chiari malformation, appropriate surgical methods that address ptosis of the hindbrain should be chosen. Each surgical approach resulted in a good improvement of neurological symptoms.
Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study
Authors: Bal Cenkhan , Alacam Alev , Tuzuner Tamer , Tirali Resmiye Ebru , Baris Emre
Published: October 2019

Objectives: The objective of this pilot study was to evaluate the effects of three different antiseptic materials on healing processes of direct pulp therapies with Ca(OH)2 histopathologically. Methods: Twenty-eight upper and lower first molar teeth from 7 male Wistar rats were used in this study. Four cavities were prepared in each rat in four quadrants, and each quadrant represented different experimental groups. In Group I: 0.5% sodium hypochlorite (NaOCl); in Group II: 2% chlorhexidine digluconate (CHX); in Group III: 0.1% octenidine dihydrochloride (OCT); and in Group IV 0.9% sterile saline was applied to the exposure site with a sterile cotton pellet for 3 minutes. After hemorrhage control, the pulps were capped with hard setting Ca(OH)2 and, finally, restored with IRM. The animals were euthanized at 21 days post-operatively. After sacrificing, routine histological procedures were performed and evaluated statistically with non-parametric Kruskal-Wallis test among the groups and two-by-two comparisons by using the Mann-Whitney U test for inflammatory response and tissue organization scores at the confidence interval of 95%. Results: There were significant differences in inflammatory response and tissue organization scores between the groups (P<.05). Statistical evaluation of inflammatory response showed that Group IV was significantly different from Groups I, II and III separately with a higher inflammatory cell response (P<.05) whereas no significant differences were detected between the other groups in two-by-two comparisons (P>.05). Healthy coronal and radicular pulp tissue organization scores indicated that the Group I has better pulp tissue organization than Group IV and this was significantly different (P<.05) whereas no significant differences were observed between the other groups separately (P>.05). Conclusions: The antiseptic materials used in this study created an environment that, rather than saline solution, may affect clinical and histological success in a positive way. (Eur J Dent 2011;5:265-272)
Comparison of Depth of Cure, Hardness and Heat Generation of LED and High Intensity QTH Light Sources
Authors: Mousavinasab Sayed Mostafa , Meyers Ian
Published: October 2019

Objectives: To compare curing performance of a second generation LED curing light with a high power tungsten quartz halogen (QTH). Methods: A hybrid composite resin (Filtek Z 250, 3M, USA) was used as test material and cured using a second generation LED light (Translux Power BlueTM, Heraus Kulzer ,Germany) or a very high power QTH light unit (EMS, Switzerland). A two split aluminum mold was used to prepare ten samples with LED light source cured for forty seconds and ten samples prepared using high power QTH light unit, cured for four or six seconds recommended exposure time. Hardness, depth of cure (DOC) and thermal rise during exposure time by these light sources were measured. The data submitted to analysis of variance (ANOVA), Tukey's and student's t tests at 5% significance level. Results: Significant differences were found in hardness, DOC of samples cured by above mentioned light sources and also in thermal rises during exposure time. The curing performance of the tested QTH was not as well as the LED light. TPB light source produced the maximum hardness (81.25, 73.29, 65.49,55.83 and 24.53 for 0 mm, 1 mm, 2 mm, 3 mm and 4 mm intervals) and DOC (2.64 mm) values with forty seconds irradiation time and the high power (QTH) the least hardness (73.27, 61.51 and 31.59 for 0 mm, 1 mm and 2 mm, respectively) and DOC (2 mm) values with four seconds irradiation time.Thermal rises during 4 s and 6 s curing time using high power QTH and tested LED were 1.88˚C, 3˚C and 1.87˚C, respectively. Conclusions: The used high power LED light produced greater hardness and depth of cure during forty seconds exposure time compared to high power QTH light with four or six seconds curing time. Thermal rise during 6 s curing time with QTH was greater compared to thermal changes occurred during 40 s curing time with tested LED light source. There was no difference seen in thermal changes caused by LED light with 40 s and QTH light with 4 s exposure time. (Eur J Dent 2011;5:299- 304)
Evaluation of oral health status and salivary flow rate in obese patients after bariatric surgery
Authors: Marsicano Juliane A , Sales-Peres Arsenio , Ceneviva Reginaldo , Sales-Peres Silvia H de C
Published: October 2019

Objectives: The aim of this study was to identify the prevalence of dental caries, periodontal diseases and tooth wear in bariatric patients, and relate the oral health conditions to saliva flow.

Methods: Fifty-two patients who had undergone bariatric surgery (Roux-en-Y gastric bypass) and 50 severely obese patients indicated for bariatric surgery were submitted to clinical examinations with regard to dental caries (DMFT index), periodontal condition (CPI index), dental wear (DWI index – Dental wear index) and saliva flow. The data were statistically analyzed by the Student’s-t , Mann- Whitney, Spearman Correlation and Chi-square (χ2) tests at 5% significance level.

Results: The DMFT index was 16.11±5.19 in the surgical group and 16.06±6.29 in the control group (P>.05). The mean CPI was 3.05±0.84 for the operated group and 2.66±1.25 for the obese patients with no significant difference between them (P>.05). There was statistically significant difference between the groups for the presence of periodontal pockets (P=.021). All the patients presented some degree of tooth wear, however, with no significant difference between the two groups (P=.82). The mean saliva flow values of the surgical group and control group were 0.64±0.46 mL/min and 0.66±0.49 mL/min, respectively. There was no significant difference in saliva flow and all oral conditions analyzed (P>.05).

Conclusion: The prevalence of oral diseases was similar in severely obese patients who were candidates for bariatric surgery and in patients who had been submitted to bariatric surgery. Nevertheless, there was higher prevalence of periodontal pockets in the operated group. (Eur J Dent 2012;6:191-197)
Influence of an external additional magnetic field on the formation of a plasma column in a dense plasma focus
Authors: Kubes P. , Paduch M. , Sadowski M. J. , Cikhardt J. , Cikhardtova B. , Klir D. , Kravarik J. , Kwiatkowski R. , Munzar V. , Rezac K. , Skladnik-Sadowska E. , Szymaszek A. , Tomaszewski K. , Zaloga D. , Zielinska E.
Published: October 2019

This paper concerns the evolution of internal structures and the neutron production in plasma-focus discharges performed in the presence of a permanent magnet (placed inside the anode front) and within a residual magnetic field (after the removal of this magnet). The initial magnetic field generated by this magnet prevented: (i) the effective compression of a dense pinch column, (ii) the formation of plasma organized structures, and (iii) the evolution of plasma instabilities. The experimental results have shown an increase in the initial magnetic field due to a magnetic dynamo effect in the presence of the permanent magnet, as well as in a series of shots performed after its removal. It was observed that the appearance of plasmoidal structures is necessary for the emission of fusion neutrons. A characteristic quasicylindrical plasma layer of the radius corresponding to the plasma lobule tops, which might be identified with a ring region of the acceleration of fast deuterons, was also observed.