bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313
Authors: Ramanathan Ramesh K. , McDonough Shannon L. , Philip Philip A. , Hingorani Sunil R. , Lacy Jill , Kortmansky Jeremy S. , Thumar Jaykumar , Chiorean E. Gabriela , Shields Anthony F. , Behl Deepti , Mehan Paul T. , Gaur Rakesh , Seery Tara , Guthrie Katherine A. , Hochster Howard S.
Published: February 2019

PURPOSE

Pegylated recombinant human hyaluronidase (PEGPH20) degrades hyaluronan (HA) and, in combination with chemotherapy, prolongs survival in preclinical models. The activity of PEGPH20 with modified fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX) was evaluated in patients with metastatic pancreatic cancer (mPC).

MATERIALS AND METHODS

Patients had untreated mPC, a performance status of 0 to 1, and adequate organ function. Tumor HA status was not required for eligibility. After a phase Ib dose-finding study of mFOLFIRINOX plus PEGPH20, the phase II open-label study randomly assigned patients (1:1) to the combination arm or to mFOLFIRINOX alone (n = 138). The primary end point was overall survival (OS).

RESULTS

PEGPH20 dosages of 3 µg/kg every 2 weeks were more tolerable than twice-weekly dosages used in the phase I study, so 3 µg/kg every 2 weeks was the phase II dosage. An amendment instituted enoxaparin prophylaxis in the PEGPH20 combination arm as a result of increased thromboembolic (TE) events. The planned interim futility analysis when 35 deaths (of 103 analyzable patients) occurred resulted in an OS hazard ratio (HR) of 2.07 that favored the control arm, and the study was closed to accrual. The treatment-related grade 3 to 4 toxicity was significantly increased in the PEGPH20 combination arm relative to control (odds ratio, 2.7; 95% CI, 1.1 to 7.1). The median OS in the mFOLFIRINOX arm was 14.4 months (95% CI, 10.1 to 15.7 months) versus 7.7 months (95% CI, 4.6 to 9.3 months) in the PEGPH20 combination arm.

CONCLUSION

Addition of PEGPH20 to mFOLFIRINOX seems to be detrimental in patients unselected for tumor HA status. This combination caused increased toxicity (mostly GI and TE events) and resulted in decreased treatment duration compared with mFOLFIRINOX alone. The median OS in the mFOLFIRINOX control arm (14.4 months) is, to our knowledge, the longest yet reported and can be considered for patients with good PS.
A thank you to DMM's peer reviewers
Authors: Hackett Rachel
Published: February 2019

The staff and editors of Disease Models & Mechanisms (DMM) wish to thank all our peer reviewers for their work in this vital role. We highlight some important changes that have been introduced to improve the peer-review process, for both authors and reviewers.
Elevated oxidative stress in pied flycatcher nestlings of eumelanic foster fathers under low rearing temperatures
Authors: Teerikorpi P. E. , Stauffer J. , Ilmonen P. , Calhim S. , Schuett W. , Laaksonen T.
Published: February 2019

Striking variation in melanin coloration within natural populations is likely due to the different fitness outcomes of alternative phenotypes in varying environmental conditions. There are two types of melanins. Eumelanins yield blackish hues, while pheomelanins yield reddish hues. The production of eumelanins requires low levels of glutathione (GSH), which is the most important intracellular antioxidant, while the production of pheomelanins requires high levels of GSH. We investigated the oxidative status of male pied flycatchers (Ficedula hypoleuca) with different degrees of melanin coloration under different temperatures during the nestling period. Moreover, we assessed the oxidative status of offspring in relation to their biological or foster father's melanin coloration and ambient temperature. To separate offspring genotype effects and paternal effects in different temperatures, we used a partial cross-foster design. The temperature differently affected the oxidative status of differently colored male pied flycatchers and their foster offspring. When the weather was relatively cold, black males had higher glutathione S-transferase levels compared to brown males, indicating enhanced stress in black males. Foster offspring of black males had lower ratio between reduced and oxidized GSH followed by higher total amount of GSH than foster offspring of brown males. Thus, foster offspring of black males seem to suffer from oxidative stress under relatively cold weather compared to those of brown males, and vice versa under relatively warm weather. While differently colored males experienced changes in their oxidative status under different temperatures, the link between father melanin coloration and offspring oxidative stress appears to be environmentally induced.
Research and the Approval Process: The Organization of Persuasion
Authors: Henry Emeric , Ottaviani Marco
Published: February 2019

An informer sequentially collects and disseminates information through costly research to persuade an evaluator to approve an activity. Payoffs and control rights are split between informer and evaluator depending on the organizational rules governing the approval process. The welfare benchmark corresponds to Wald’s classic solution for a statistician with payoff equal to the sum of informer and evaluator. Organizations with different commitment power of informer and evaluator are compared from a positive and normative perspective. Granting authority to the informer is socially optimal when information acquisition is sufficiently costly. The analysis is applied to the regulatory process for drug approval. (JEL D82, D83, I18, L51, L65, O31)
The Human Capital Stock: A Generalized Approach: Reply
Authors: Jones Benjamin F.
Published: February 2019

Human capital differences across countries can appear large or small depending on measurement methods. This Reply clarifies key assumptions and conceptual distinctions across accounting approaches. Accounting-based arguments for small human capital differences are difficult to sustain. By contrast, large human capital differences are theoretically and empirically coherent. Non-accounting arguments against large human capital variation are examined and their weaknesses pinpointed. This Reply also suggests a fruitful way forward for this literature, providing a natural conception of human capital that integrates literatures on ideas and institutions with the accounting of Jones (2014). (JEL E24, I26, J24, J31)
Uma questão de justiça
Authors: Segatto Cristiane , Ferreira Junior Walter Cintra
Published: February 2019

A crescente judicialização compromete a melhor alocação dos recursos da saúde no Brasil. Alguns magistrados, porém, acreditam que ela é benéfica.
Dilemas éticos do RH
Authors: Braga Beatriz Maria
Published: February 2019

Guardar ou não informações sigilosas? Escamotear ou denunciar práticas desonestas? Disfuncionalidades organizacionais fazem com que os profissionais de recursos humanos enfrentem difíceis questões.
National culture as a correlate of research impact and productivity
Authors: Abraham Juneman
Published: February 2019

National culture has been overlooked in discussions related to research productivity and impact owing to individual, socio-political structure, and economic factors. This study shows the relationships between the dimensions of cultural value orientation of the nation and research performance indicators. More than 60 countries were included and Pearson correlation analysis was employed. The variables were taken from Geert Hofstede and Scimago Journal & Country Rank worksheets. This study found that (1) Individualism has significant correlations with the majority of the indicators; (2) Power distance and indulgence correlate with a country’s research impact in the form of citation per document; (3) Masculinity, long term orientation, and uncertainty avoidance do not correlate with the indicators. Owing to the fact that the national culture is relatively enduring, countries need to measure their elasticity of hopes and action plans in an effort to boost research productivity and impact, by integrating the national culture in the estimate.
Self-reported Anxiety Sensitivity Index in the TwinsUK cohort
Authors: Abbasian Golboo , Lachance Genevieve , Yarand Darioush , Hart Deborah , Spector Tim , Steves Claire
Published: February 2019

The anxiety sensitivity (AS) construct has received considerable attention in anxiety research and is considered to be a cognitive vulnerability factor for the study of anxiety related disorders. The Anxiety Sensitivity Index (ASI) is the most widely used instrument for the study of AS. The present Data Note provides an overview of all the 16-item ASI questionnaires filled and returned by the twins in the TwinsUK registry. This work does not provide any multidimensional or factor structure analysis of the responses provided. TwinsUK registry encompasses a wide range of clinical and self-reported data that can be used as confounding factors in the study of cognitive and mental health.
Alternative to antibiotics for managing asymptomatic and non-symptomatic bacteriuria in older persons: a review
Authors: Duncan Debbie
Published: February 2019

Recurrent urinary tract infection (UTI) is one of the most common reasons for long-term antibiotic use in frail older people, and these individuals often have non-symptomatic bacteriuria. This article reviews the literature and recommendations for the treatment of UTIs particularly in the older population (>65 years). It considers the question: is there an alternative for antibiotics for asymptomatic and non-symptomatic bacteriuria in older adults? D-mannose powder has been recommended for the treatment of UTIs, as when applied locally, it reduces the adherence of Escherichia coli. In one study, D-mannose was reviewed for the prophylaxis of recurrent UTIs in women, and the findings indicated that it may be useful for UTI prevention instead of prophylactic antibiotics. There is a lack of information about the efficacy of cranberry products combined with D-mannose in this regard, and this is an area for further research.
T.I.M.E. to improve patient outcomes: use of a clinical decision support tool to optimise wound care
Authors: Dowsett Caroline
Published: February 2019

Patients with wounds pose an important healthcare challenge. Many of these wounds are managed in community care and can take weeks or months to resolve. Delays in wound healing can be perpetuated by clinicians who make poor treatment choices, fail to recognise complications and/or do not seek timely advice. Improving patient outcomes requires a proactive approach to care that includes accurate and timely assessment and re-assessment, treatment of the underlying cause using a multidisciplinary team approach and the use of evidence-based practice and clinical judgement to develop an appropriate treatment plan. A structured approach to care, such as the newly developed T.I.M.E. clinical decision support tool, has the potential to improve wound healing outcomes and reduce the burden of chronic wounds in community nursing services.
Listen and learn
Authors: Bainham Lisa
Published: February 2019

Lisa Bainham, president of the Association of Dental Administrators and Managers (ADAM), gives her thoughts on patient feedback
Network and learn
Authors: Smith Louise
Published: February 2019

The Society of British Dental Nurses East Midlands branch is hosting its 4th Dental Symposium in the East Midlands. Louise Smith reports
Start. Run. Grow.
Authors: Kauldhar Apri , Price Heidi
Published: February 2019

Dental nurses Apri Kauldhar and Heidi Price hit the groud running when their joint entrepreneurial spirit spurred them on to start their own business. Here, they share their journey…
An overview of the Chrysididae (Hymenoptera) of the Red Sea Farasan Archipelago (Saudi Arabia)

Authors: STRUMIA FRANCO , DAWAH HASSAN
Published: February 2019

A survey of the Chrysididae (Insecta: Hymenoptera) of the Farasan Archipelago (Red Sea) was undertaken, mainly using Malaise traps and sweep nets from 2012 to 2017. Twenty-eight species belonging to eight genera were identified and recorded in this study (four of which are new records for the south-western Saudi Arabia). We have described four new species: (Hedychridium azizi sp. nov., Chrysis farasanensis sp. nov., Chrysis decolorata ssp. nov., Trichrysis flavicornis sp. nov.) A list of all species of Chrysididae recorded from the major Farasan Island is provided. The Chrysididae population of the Farasan Archipelago is composed mainly of species of South West Palaearctic Region. The presence of a few Afrotropical species is evidence of their expansion in the nearby Southern Arabia. Key word: Chrysididae, cuckoo wasp, Saudi Arabia, Jazan, Farasan Island, new species
The role of histology in the diagnosis of spondylodiscitis
Authors: Iwata E. , Scarborough M. , Bowden G. , McNally M. , Tanaka Y. , Athanasou N. A.
Published: February 2019

Aims

The aim of this study was to determine the diagnostic utility of histological analysis in spinal biopsies for spondylodiscitis (SD).

Patients and Methods

Clinical features, radiology, results of microbiology, histology, and laboratory investigations in 50 suspected SD patients were evaluated. In 29 patients, the final (i.e. treatment-based) diagnosis was pyogenic SD; in seven patients, the final diagnosis was mycobacterial SD. In pyogenic SD, the neutrophil polymorph (NP) infiltrate was scored semi-quantitatively by determining the mean number of NPs per (×400) high-power field (HPF).

Results

Of the 29 pyogenic SD patients, 17 had positive microbiology and 21 positive histology (i.e. one or more NPs per HPF on average). All non-SD patients showed less than one NP per HPF. The presence of one or more NPs per HPF had a diagnostic sensitivity of 72.4%, specificity 100%, accuracy 100%, positive predictive value (PPV) 81.0%, and negative predictive value (NPV) 61.9%. Sensitivity, specificity, and accuracy were greater using the criterion of positive histology and/or microbiology than positive histology or microbiology alone. Granulomas were identified histologically in seven mycobacterial SD patients, and positive microbiology was detected in four.

Conclusion

The diagnosis of pyogenic SD was more often confirmed by positive histology (one or more NPs per HPF on average) than by microbiology, although diagnostic sensitivity was greater when both histology and microbiology were positive. Cite this article: Bone Joint J 2019;101-B:246–252.
The risks following the exposure to radiation associated with the surgical correction of limb deformities in children are minimal
Authors: Leaver T. , Johnson B. , Lampard J. , Aarvold A. , Uglow M.
Published: February 2019

Aims

The aim of this study was to quantify the risk of developing cancer from the exposure to radiation associated with surgery to correct limb deformities in children.

Patients and Methods

A total of 35 children were studied. There were 19 girls and 16 boys. Their mean age was 11.9 years (2 to 18) at the time of surgery. Details of the radiological examinations were recorded during gradual correction using a Taylor Spatial Frame. The dose area product for each radiograph was obtained from the Computerised Radiology Information System database. The effective dose in millisieverts (mSv) was calculated using conversion coefficients for the anatomical area. The lifetime risk of developing cancer was calculated using government-approved Health Protection Agency reports, accounting for the age and gender of the child.

Results

Correction was undertaken in five femurs, 18 tibiae, and 12 feet. The median duration of treatment was 45 months (11 to 118). The mean effective dose was 0.31 mSv (0.05 to 0.64) for the femur, 0.29 mSv (0.01 to 0.97) for the tibia, and 0.027 mSv (0.001 to 0.161) for the foot. The cumulative exposure gave ‘negligible’ risk in 26 children and ‘minimal’ risk in nine children, according to Public Health England categories. These results are below the mean annual background radiation in the United Kingdom.

Conclusion

The lifetime attributable risk of developing cancer from repeated exposure to radiation was negligible or minimal in all children. This is the first study to quantify the exposure to radiation from serial radiographs in children with limb deformities who are treated surgically using circular external fixation, linking this to the risk of developing cancer. Cite this article: Bone Joint J 2019;101-B:241–245.
The effect of surgery in tenosynovial giant cell tumours as measured by patient-reported outcomes on quality of life and joint function
Authors: Verspoor F. G. M. , Mastboom M. J. L. , Hannink G. , van der Graaf W. T. A. , van de Sande M. A. J. , Schreuder H. W. B.
Published: February 2019

Aims

The aim of this study was to evaluate health-related quality of life (HRQoL) and joint function in tenosynovial giant cell tumour (TGCT) patients before and after surgical treatment.

Patients and Methods

This prospective cohort study run in two Dutch referral centres assessed patient-reported outcome measures (PROMs; 36-Item Short-Form Health Survey (SF-36), visual analogue scale (VAS) for pain, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)) in 359 consecutive patients with localized- and diffuse-type TGCT of large joints. Patients with recurrent disease (n = 121) and a wait-and-see policy (n = 32) were excluded. Collected data were analyzed at specified time intervals preoperatively (baseline) and/or postoperatively up to five years.

Results

A total of 206 TGCT patients, 108 localized- and 98 diffuse-type, were analyzed. Median age at diagnosis of localized- and diffuse-type was 41 years (interquartile range (IQR) 29 to 49) and 37 years (IQR 27 to 47), respectively. SF-36 analyses showed statistically significant and clinically relevant deteriorated preoperative and immediate postoperative scores compared with general Dutch population means, depending on subscale and TGCT subtype. After three to six months of follow-up, these scores improved to general population means and continued to be fairly stable over the following years. VAS scores, for both subtypes, showed no statistically significant or clinically relevant differences pre- or postoperatively. In diffuse-type patients, the improvement in median WOMAC score was statistically significant and clinically relevant preoperatively versus six to 24 months postoperatively, and remained up to five years’ follow-up.

Conclusion

Patients with TGCT report a better HRQoL and joint function after surgery. Pain scores, which vary hugely between patients and in patients over time, did not improve. A disease-specific PROM would help to decipher the impact of TGCT on patients’ daily life and functioning in more detail. Cite this article: Bone Joint J 2019;101-B:272–280.
Patient-specific meniscus prototype based on 3D bioprinting of human cell-laden scaffold
Authors: Filardo G. , Petretta M. , Cavallo C. , Roseti L. , Durante S. , Albisinni U. , Grigolo B.
Published: February 2019

Objectives

Meniscal injuries are often associated with an active lifestyle. The damage of meniscal tissue puts young patients at higher risk of undergoing meniscal surgery and, therefore, at higher risk of osteoarthritis. In this study, we undertook proof-of-concept research to develop a cellularized human meniscus by using 3D bioprinting technology.

Methods

A 3D model of bioengineered medial meniscus tissue was created, based on MRI scans of a human volunteer. The Digital Imaging and Communications in Medicine (DICOM) data from these MRI scans were processed using dedicated software, in order to obtain an STL model of the structure. The chosen 3D Discovery printing tool was a microvalve-based inkjet printhead. Primary mesenchymal stem cells (MSCs) were isolated from bone marrow and embedded in a collagen-based bio-ink before printing. LIVE/DEAD assay was performed on realized cell-laden constructs carrying MSCs in order to evaluate cell distribution and viability.

Results

This study involved the realization of a human cell-laden collagen meniscus using 3D bioprinting. The meniscus prototype showed the biological potential of this technology to provide an anatomically shaped, patient-specific construct with viable cells on a biocompatible material.

Conclusion

This paper reports the preliminary findings of the production of a custom-made, cell-laden, collagen-based human meniscus. The prototype described could act as the starting point for future developments of this collagen-based, tissue-engineered structure, which could aid the optimization of implants designed to replace damaged menisci. Cite this article: G. Filardo, M. Petretta, C. Cavallo, L. Roseti, S. Durante, U. Albisinni, B. Grigolo. Patient-specific meniscus prototype based on 3D bioprinting of human cell-laden scaffold. Bone Joint Res 2019;8:101–106. DOI: 10.1302/2046-3758.82.BJR-2018-0134.R1.
Radical scavenging of poly(methyl methacrylate) bone cement by rifampin and clinically relevant properties of the rifampin-loaded cement
Authors: Funk G. A. , Menuey E. M. , Cole K. A. , Schuman T. P. , Kilway K. V. , McIff T. E.
Published: February 2019

Objectives

The objective of this study was to characterize the effect of rifampin incorporation into poly(methyl methacrylate) (PMMA) bone cement. While incompatibilities between the two materials have been previously noted, we sought to identify and quantify the cause of rifampin’s effects, including alterations in curing properties, mechanical strength, and residual monomer content.

Methods

Four cement groups were prepared using commercial PMMA bone cement: a control; one with 1 g of rifampin; and one each with equimolar amounts of ascorbic acid or hydroquinone relative to the amount of rifampin added. The handling properties, setting time, exothermic output, and monomer loss were measured throughout curing. The mechanical strength of each group was tested over 14 days. A radical scavenging assay was used to assess the scavenging abilities of rifampin and its individual moieties.

Results

Compared with control, the rifampin-incorporated cement had a prolonged setting time and a reduction in exothermic output during polymerization. The rifampin cement showed significantly reduced strength and was below the orthopaedic weight-bearing threshold of 70 MPa. Based on the radical scavenging assay and strength tests, the hydroquinone structure within rifampin was identified as the polymerization inhibitor.

Conclusion

The incorporation of rifampin into PMMA bone cement interferes with the cement’s radical polymerization. This interference is due to the hydroquinone moiety within rifampin. This combination alters the cement’s handling and curing properties, and lowers the strength below the threshold for weight-bearing applications. Additionally, the incomplete polymerization leads to increased toxic monomer output, which discourages its use even in non-weight-bearing applications. Cite this article: G. A. Funk, E. M. Menuey, K. A. Cole, T. P. Schuman, K. V. Kilway, T. E. McIff. Radical scavenging of poly(methyl methacrylate) bone cement by rifampin and clinically relevant properties of the rifampin-loaded cement. Bone Joint Res 2019;8:81–89. DOI: 10.1302/2046-3758.82.BJR-2018-0170.R2.
Surgery and the NHS long term plan
Authors: Alderson Derek
Published: February 2019

What does the future hold for surgeons and patient care?
Comparative effects of amiodarone and dronedarone treatments on cardiac function in a rabbit model
Authors: Boonhoh Worakan , Kijtawornrat Anusak , Sawangkoon Suwanakiet
Published: February 2019

Aim: The objective of the study was to compare the effects of amiodarone (AM) and dronedarone (DR) on heart rate variability (HRV) and cardiac contractility in a rabbit model.

Materials and Methods: A total of 16 male New Zealand white rabbits were divided into two groups, treated either with AM or DR at incremental dosages of 50 mg/kg/day (AM50 and DR50) and 100 mg/kg/day (AM100 and DR100), orally administrated for 7 days. At the end of each period, electrocardiograms were recorded during consciousness and analyzed using the short-term time and frequency domains of HRV. Standard echocardiography and speckle-tracking echocardiography were studied during immobilization with xylazine and ketamine.

Results: The results showed that AM100 and DR100 significantly decreased heart rate, total power, low-frequency component, and low-to-high frequency ratio compared with baselines. Most echocardiogram parameters revealed no significant difference from baselines, except for the global circumferential plane strain rate and time to peak standard deviation of strain, which had statistical significances after treating with AM.

Conclusion: Both AM and DR possess negative chronotropy and reduce HRV, which may be explained by their sympathetic suppression and calcium channel blocking activities. Theoretically, both antiarrhythmic drugs may also possess negative inotropy, but only AM is shown to have a negative inotropic effect and reduces cardiac dyssynchrony in this model.
To Activate the Brain, Activate the Body First
Authors: Habibzadeh Nasim
Published: February 2019

The brain is the most complex organ which governs almost all activities in human body. Thus, the mental fitness has high level of importance in every day workouts. The good activities for long-term brain health include performing regular exercises such as a simple walking for 10 min at each day. More importantly having good level of diet can keep the brain workouts in an ideal situation. Indeed, taking enough rest can enhance the brain performances. Listening to the desirable sound of music could also enhance concentration and improve the mood. In overall, these aforementioned life style modifications significantly can easily boost the brain power and its healthy function through different aspects in daily life.
Rice Epigenetic Pathways: Great Genetic Variation and Implication for Rapid Rice Breeding
Authors: Li Yuan , Persson Erik , Persson Erik
Published: February 2019

Rice, as one of the most important crops in the world, is facing an ever-accelerating challenge from climate change. Epigenetic modification with its substantially high epimutation rate and the possibility for some epigenetic variation to act as a heritable contributor to crop environmental adaptability may hold great potentials for rapid crop breeding. Epigenetic modification is controlled by epigenetic pathways, and mutations disturbing the epigenetic pathways may lead to significant epigenetic and/or genetic changes. This is especially true for rice, whose genome is rich in epigenetic modifications and transposable elements (TEs) that are generally epigenetically silenced. Here, in this paper, we first reviewed the pathways that establish, maintain and remove rice DNA methylation, which is the most well studied epigenetic marker, as well as the genes that are involved. We then discussed how TEs amplify the phenotypic impact of epigenetic changes that could be a result of epigenetic pathway disturbances. At last, we presented the enormous amount of rice genome data that are publically available, within which great genetic variation in the genes that are involved within the epigenetic pathways is embedded. This genetic variation awaits to be exploited for their potentials in generating a heritable source of variation for rapid environmental adaptation, which may hold tremendous importance for rice breeding in the face of climate change.
Pengaruh Penggunaan Teknologi Tepat Guna dalam Meningkatkan Produktivitas UKM Batik Tulis di Kampung Batik Kauman Kota Pekalongan
Authors: Irhandayaningsih Ana
Published: February 2019

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan teknologi tepat guna dalam peningkatan produktivitas UKM Batik Mas dan Batik Nulaba melalui perbaikan proses produksi, pemasaran, dan manajemen. Teknologi tepat guna yang diterpatkan adalah penerapan mesin feeder pewarnaan batik yang akan diaplikasikan di UKM Batik Mas, pendampingan teknik integrated digital marketing serta penerapan mini studio skala UKM untuk meningkatkan kualitas foto produk di UKM Batik Nulaba, workshop ergonomic dan keselamatan kerja di UKM Batik Mas, pendampingan teknik Search Engine Optimation untuk meningkatkan pengunjung online di UKM Batik Nulaba, serta pendampingan teknik customer relationship management di UKM Batik Mas. Dampak yang dihasilkan bagi UKM Batik Mas adalah jumlah tenaga kerja yang terlibat menjadi berkurang, waktu proses pewarnaan berkurang, dan postur kerja pewarnaan mengalami perbaikan. Dampak yang dihasilkan bagi UKM Batik Nulaba adalah adanya katalog online dan jangkauan pemasaran semakin banyak, serta jumlah penjualan meningkat.
Dongeng, Mendongeng, dan Manfaatnya
Authors: Rukiyah Rukiyah
Published: February 2019

Mendongeng merupakan tradisi yang sudah dimiliki oleh bangsa Indonesia berabad-abad yang lalu yang perlu dilestarikan karena banyak manfaat yang bisa diambil dari kegiatan tersebut. Tulisan ini mendeskripsikan tentang pengertian dongeng, mendongeng, dan manfaatnya. Metode penelitian yang digunakan adalah metode kualitatif. Data yang diperlukan diperoleh dengan studi pustaka dan selanjutnya diinterpreasi. Tahap selanjutnya dideskripsikan tentang dongeng, mendongeng dan manfaatnya. Dongeng adalah cerita prosa rakyat yang dianggap tidak benar-benar terjadi. Manfaat yang bisa dipetik  dari kegiatan mendongeng adalah: menumbuhkan sikap proaktif, 2) mempererat hubungan anak dengan orang tua. 3) menambah pengetahuan, 4) melatih daya konsentrasi, 5) menambah perbendaharaan kata, 6) menumbuhkan minat baca, 7) memicu daya pikir kritis anak, 8) merangsang imajinasi, fantasi, dan kreativitas anak, 9) memberi pelajaran tanpa terkesan menggurui.
Peran Perpustakaan dalam Mewujudkan Budaya Informasi Masyarakat
Authors: Christiani Lydia
Published: February 2019

Pengetahuan adalah kekuatan. Hal inilah yang mendasari perkembangan peradaban umat manusia memasuki sebuah era yang berdasar pada kekuatan informasi, yang dikenal dengan istilah era informasi. Era ini menuntut adanya berbagai perubahan dalam struktur masyarakat, baik dalam dimensi historis, ekonomis, politis, maupun sosial budaya yang berorientasi pada kegiatan mengkreasikan, mendistribusi, dan memanfaatkan informasi. Struktur masyarakat tersebut dikenal dengan istilah masyarakat informasi, sebuah konsep masyarakat yang melakukan kegiatan pengelolaan informasi sebagai kegiatan sentral yang dilakukan untuk mengaktualisasikan diri dalam kehidupan. Struktur masyarakat baru ini, melahirkan berbagai tingkatan dalam struktur kemasyarakatannya yang melahirkan golongan masyarakat kaya informasi dan masyarakat miskin informasi. Kedua golongan masyarakat informasi ini dipisahkan oleh jurang informasi yang cukup lebar, kondisi inilah yang akhirnya memacu perpustakaan sebagai lembaga informasi non profit untuk berdiri sebagai penengah dan berupaya untuk menjembatani jurang informasi tersebut, agar informasi dapat tersebar dengan lebih merata dan dapat dimanfaatkan oleh setiap individu dalam masyarakat informasi untuk mengaktualisasikan diri, sehingga pada akhirnya perpustakaan mampu mendorong terwujudnya budaya informasi yang sehat bagi seluruh masyarakat.
Korespondensi dalam Bahasa Inggris oleh Pengusaha Ukir di Jepara
Authors: Sundari Wiwiek
Published: February 2019

Penelitian ini berjudul Korespondensi Dalam Bahasa Inggris Oleh Pengusaha Ukir Di Jepara yang bertujuan menggambarkan pemakaian bahasa Inggris tulis oleh pengusaha ukir Jepara, yang dikelompokan ke dalam tiga kategori yaitu pengusaha besar, pengusaha menengah, dan pengusaha kecil. Pendekatan yang digunakan adalah sosiolinguistik. Pengumpulan data dilakukan melalui data sekunder, kuesioner dan wawancara. Responden ini dikelompokan ke dalam pengusaha besar, pengusaha menengah, dan pengusaha kecil. Analisis dilakukan terhadap item dalam kuesioner dan hubungan antar item. Hasil penelitian menggambarkan bahwa koserpondensi dalam bahasa Inggris lebih banyak dilakukan oleh pengusaha besar. Pengusaha besar mengerti lebih banyak mengenai tatanan surat dan bagian-bagian surat daripada pengusaha menengah dan pengusaha kecil. Ada kesamaan bahwa ketiga kelompok kategori tetap menyadari pentingnya peningkatan kemepuan berbahasa Inggris.
FENOMENA JOSHI KOSEI DALAM KEHIDUPAN MASYARAKAT JEPANG
Authors: Mulyadi Budi
Published: February 2019

(Title: Joshi Kosei  in The Life of Japanese Society). The main goal of this research is to know about Joshi Kosei (A Teenager Prostitution) in The Life of Japanese Society. This research is a combination between field and library reserach. Main method are observation, interview, interpretation. The research show the history of prostitution in Japan, the factors, and the effects for teenagers who are doing the job. The law in Japan has taken prostitution as a legal job, but it engenders a social problem especially a prostitution that involved teenagers. For Japanese people prostitution is not something taboo, it becomes a bussiness which is developed really fast in JapanKeywords : Joshi Kosei; Prostitution; Japanese Society
MAKNA VERBA MAJEMUK BAHASA JEPANG ~KAESU
Authors: Rosliana Lina , Lailatussoimah Ida
Published: February 2019

(Title: Semantic Meaning of Japanese Compound Verbs ~kaesu). Compound verbs (fukugoudoushi) are compound words formed from a combination of at least two morphemes that have new grammatical meanings and functions as a verb. Compound verbs in Japanese can be formed from the combination of nouns with verbs (N + V), verbs with verbs (V1 + V2), adjectives with verbs (A + V), and adverbs with verbs (AD + V). The results of the combination structure above can produce diverse meanings. One of the causes is the presence of several verbs forming the back of the elements whose characteristics have many meanings. For example in the verb kaesu. Besides acting as an element forming the back, kaesu can also act as an element forming the front.  Kaesu can form many compound verbs with different meanings. The aim of this research is to describe the semantic meaning of compound verbs –kaesu. The data being used are obtained from the website and some online news articles. The data were collected by library study, observation and writing technique. Then, the research data were analyzed using distributional method. The results of the analysis are presented by an informal method which is explained with simple words.
Higher-order anisotropic models in phase separation
Authors: Cherfils Laurence , Miranville Alain , Peng Shuiran
Published: February 2019

Our aim in this paper is to study higher-order (in space) Allen–Cahn and Cahn–Hilliard models. In particular, we obtain well-posedness results, as well as the existence of the global attractor. We also give, for the Allen–Cahn models, numerical simulations which illustrate the effects of the higher-order terms and the anisotropy.
Post-translational modification-derived products are associated with frailty status in elderly subjects
Authors: Mahmoudi Rachid , Jaisson Stéphane , Badr Sarah , Jaidi Yacine , Bertholon Laurie-Anne , Novella Jean-Luc , Gillery Philippe
Published: February 2019

Background

Identifying frail elderly subjects is of paramount importance in order to conduct a tailored care. The characterization of frailty status is currently based on the collection of clinical data and on the use of various tools such as Fried’s criteria, which constitutes a difficult and time-consuming process. Up to now, no biological markers have been described as reliable tools for frailty characterization. We tested the hypothesis that a link between frailty and protein molecular aging existed. This study aimed therefore at determining whether post-translational modification derived products (PTMDPs), recognized as biomarkers of protein aging, were associated with frailty status in elderly subjects.

Methods

Frailty status was determined according to Fried’s criteria in 250 elderly patients (>65 years old) hospitalized in a short-term care unit. Serum concentrations of protein-bound PTMDPs, including carboxymethyllysine (CML), pentosidine, methylglyoxal-hydroimidazolone-1 and homocitrulline (HCit), were determined by liquid chromatography coupled with tandem mass spectrometry, and tissue content of advanced glycation end-products was assessed by skin autofluorescence (SAF) measurement. Associations between PTMDPs and frailty status were analyzed using logistic regression models.

Results

Frail patients had significantly (p<0.01) higher CML, HCit, and SAF values compared to non-frail and pre-frail subjects. By multivariate analysis, only HCit concentrations and SAF values remained associated with frailty status (p=0.016 and p=0.002, respectively), independently of age, comorbidities, renal function, C-reactive protein and albumin concentrations.

Conclusions

HCit and SAF are significantly associated with frailty status in elderly subjects. This study suggests that PTMDPs constitute promising biomarkers for identifying frail patients and guiding personalized patient care.
Fatale Orthodoxie
Authors: Müller-Doohm Stefan , Yos Roman
Published: February 2019

Our reply to Fabian Freyenhagen’s article “Was ist orthodoxe Kritische Theorie?” (DZPhil 65.3 [2017], 456-469) raises the question whether his proposal that Critical Theory only “be adequately and appropriately critical” without a program of justification spares the search for any general criteria. Answering negatively we conversely want to recall, particularly with regard to Horkheimers’s and Adornos’sDialectic of Enlightmentas well as Habermas‘s concept of an emancipatory interest, that such a criterion as a normative foundation of critique is crucial not only for systematical purposes, but also recognised as necessary in this respect by Adorno, who Freyenhagen wants to play off against programs of justification. Critical Theory needs to be clear in this respect. Against this background we are questioning Freyenhagen‘s recourse to an “interest in abolishing social injustice” as the “only criterion for Critical Theory.” Because Freyenhagen ignores the fact that Critical Theory has been understood by its representatives in a twofold manner – as a theoretical program of justification for one and secondly as a cultural diagnosis – his plea for an orthodox Critical Theory is endangered by decisionism.
Effect of Ammonia Modification on Activated Carbons for the Removal of Acidic Anthraquinone Dyes
Authors: Yaacoubi Hind , Songlin Zuo
Published: February 2019

The objective of this research is to study the retention of two acidic anthraquinone dyes by Coconut-shell-based activated carbon. Ultimately, this work allows the valorization of this new material as an adsorbent. The effect of ammonia modification on the adsorption capacity of activated carbon towards remazol brilliant blue R19 (RB19) and acid blue 25 (AB25), has been studied. Coconut-shell-based activated carbon material was modified under ammonia flow at 900 and 1000 °C. The adsorption rates and isotherms of RB19 and AB25 on the resultant materials were then tested. The results show that ammonia modification remarkably increases the adsorption capacities of the activated carbons to RB19 and AB25, by a factor of 2–3 after treatment at 1000 °C (From 0.22 mmol g−1 and 1.04 mmol g−1 to 0.76 mmol g−1 and 2.19 mmol g−1 on AC and AC-O-N-1000, respectively). The increased adsorption capacity is attributed to the introduction of basic nitrogen-containing functional groups and enhanced pore development by ammonia modification. The collected experimental kinetic and isotherm data are well compatible with the intraparticle diffusion kinetic model and the Langmuir isotherm model. According to these results, the adsorption affinity is homogeneous in terms of surface functional groups and the surface bears a finite number of identical adsorption sites.
Reduction of Electric Field Stress on the Surface Contour and at the Triple Junction in UHVAC GIS by Spacer Design Optimization
Authors: Ladani Mitalkumar , Preetha P
Published: February 2019

The conical spacers made of epoxy resin are widely used in Gas Insulated System(GIS) for electrical insulation as well as mechanical support to the conductor. Electric stress on the surface of the spacer as well as at the triple junction is of major concern while designing the spacer for the Ultra High Voltage Alternating Current (UHVAC) GIS. To reduce the possibility of the flashover, the tangential field at the concave and convex surfaces is to be within limits. This paper presents a stepwise method for the reduction of the electric field at the spacer surface and at the triple junction by geometry shape optimization. The electric field has been calculated by solving Laplacian equation by Finite Element Method(FEM). Optimization has been realized by incorporating Nelder-Mead(NM) algorithm with FEM solution. The tangential field at the concave and convex surface of the conical spacer has been optimized by changing the shielding ball shape and metal inert in the spacer as well as by changing the curvature and thickness of spacer near to the high voltage conductor. The results demonstrate the reduction in the principle stress for the optimized geometry shape and the stress at the triple junction. The improvement in the electric field uniformity for the spacer surface is seen in the final optimized geometry
The Relation of Satisfaction, Self-Confidence and Emotion in a Simulated Environment
Authors: Mano Leandro , Mazzo Alessandra , Torres Neto Jose Rodrigues , Filho Cezar Kayzuka Cotta , Goncalves Vinicius Pereira , Ueyama Jo , Pereira Junior Gerson Alves
Published: February 2019

Clinical simulation allows discussions about improving the quality on the patient’s care. This method have effectiveness on what concerns to satisfaction, self-confidence and student motivation. However, during the assessment, the students have emotional reactions that have tended to be overlooked. In view of this, this article seeks to identify and describe the relationship of the emotions observed by facial expressions and assess their degree of satisfaction and self-confidence by carrying out simulated practices among the nursing students. The analysis based on the scales showed high satisfaction and self-confidence levels, and it was found that the predominant basic emotion was anger, which is caused by other correlated emotions like tension and stress. This divergence between the identified emotions opens up space for further investigations about the level of motivation and the stimulus tolearning that these emotions can provide, and the extent to which they can lead to satisfaction and self-confidence.
A learner corpus analysis: Effects of task complexity, task type, and L1 & L2 similarity on propositional and linguistic complexity
Authors: Allaw Elissa
Published: February 2019

Learner corpora provide researchers with a rich pool of resources that can complement experimental studies. The purpose of the present paper is to provide task complexity researchers, for the first time, with further insight regarding interactive effects of task complexity, task type, task modality, and L1 background on linguistic and propositional complexity. Analyzing 720 intermediate-level (B1) written texts that were extracted from open access online language learning platform, the EF-Cambridge Open Language Database (EFCAMDAT) revealed that there was a significant interaction effect among task design features (task complexity, task type, and L1 background) that influenced linguistic and propositional complexity of written texts. This suggests that task complexity does not function in isolation of other task design features such as task type and L1 background.
Towards memory integrity and authenticity of multi-processors system-on-chip using physical unclonable functions
Authors: Sepúlveda Johanna , Wilgerodt Felix , Pehl Michael
Published: February 2019

A persistent problem for modern Multi-Processors System-on-Chip (MPSoCs) is their vulnerability to code injection attacks. By tampering the memory content, attackers are able to extract secrets from the MPSoC and to modify or deny the MPSoC’s operation. This work proposes SEPUFSoC (Secure PUF-based SoC), a novel flexible, secure, and fast architecture able to be integrated into any MPSoC. SEPUFSoC prevents execution of unauthorized code as well as data manipulation by ensuring memory integrity and authentication. SEPUFSoC achieves: i) efficiency, through the integration of a fast and lightweight hash function for Message Authentication Code (MAC) generation and integrity verification of the memory lines at runtime; and ii) lightweight security, through the use of a Physical Unclonable Function (PUF) to securely generate and store the cryptographic keys that are used for the application authentication. We discuss the security and performance of SEPUFSoC for single core and multi-core systems. Results show that the SEPUFSoC is a secure, fast, and low overhead solution for MPSoCs. We discuss the SEPUFSoC security and cost, which strongly depends on the PUF and hash selection. In the future, new technologies may allow the exploration of different PUFs.
On the Interpretation of do(x)do(x)
Authors: Pearl Judea
Published: February 2019

This paper provides empirical interpretation of the

d
o
(
x
)

do(x)

operator when applied to non-manipulable variables such as race, obesity, or cholesterol level. We view

d
o
(
x
)

do(x)

as an ideal intervention that provides valuable information on the effects of manipulable variables and is thus empirically testable. We draw parallels between this interpretation and ways of enabling machines to learn effects of untried actions from those tried. We end with the conclusion that researchers need not distinguish manipulable from non-manipulable variables; both types are equally eligible to receive the

d
o
(
x
)

do(x)

operator and to produce useful information for decision makers.
Assessment of maternal GBS colonization and early-onset neonatal disease rate for term deliveries: a decade perspective
Authors: Rottenstreich Misgav , Rotem Reut , Bergman Marva , Farkash Rivka , Schimmel Michael S. , Samueloff Arnon , Grisaru-Granovsky Sorina
Published: February 2019

Objective

To assess the maternal group B streptococcal (GBS) colonization rate and neonatal early-onset GBS (EOGBS) disease in term deliveries, a decade apart.

Methods

This was a retrospective computerized study between 2005 and 2016. A universal GBS culture-based approach gradually replaced the GBS risk-oriented screening. A vaginal-rectal culture taken at 35–37 weeks was recorded at admission for delivery.

Results

We identified 149,910 term deliveries during the study period. GBS status was recorded in 53,879 (35.9%) cases. The GBS screening rate constantly increased from 20% in 2005 to 47.5% in 2016. GBS colonization rates significantly decreased, from 50.3% in 2005 to 31.7% in 2016, P<0.001. Overall, EOGBS disease was diagnosed in 37 term neonates (0.25 per 1000 live births.). The rate of EOGBS in neonates decreased dramatically from 0.361 per 1000 deliveries between 2005 and 2009 to 0.19 per 1000 deliveries between 2010 and 2016 (P<0.05). During the latter period, over 35% of the deliveries were screened for GBS. Remarkably, 64.9% of the EOGBS originated in the non-screened population.

Conclusion

The universal screening policy was associated with a significant decrease in neonatal EOGBS and therefore should be adopted. Further national surveillance studies should be performed in order to validate this approach.