bluuebunny/crossref_metadata_2025 huggingface dataset:
Mediating role of Cognitive Fusion in the Relationship of Mindfulness and Test Anxiety among Female Undergraduate Students of Shahid Chamran University of Ahvaz
Authors: Asghari F , Sayadi A , Ghasemi Jobaneh R , Baharvand I
Published: March 2020

Introduction: Test anxiety, is one of the Psychological-educational problems that have a higher prevalence in female students. Mindfulness and cognitive fusion can play a remarkable role in explaining psychological problems. The aim of current research was to investigate the mediating role of Cognitive fusion in the relationship of mindfulness and test anxiety among female undergraduate students of Shahid Chamran University of Ahvaz.
Methods: the current research design is Descriptive correlation and the used method is Structural equation based on Partial least squares approach. A sample of 120 people were selected by Voluntary sampling method from the population of female Undergraduate students of Shahid Chamran University of Ahvaz. Test anxiety questionnaire, short form of mindfulness inventory and cognitive fusion questionnaire were used for data collection. The gathered data were analyzed by SPSS 21 and SmartPLS 2 software at the level of 0.01.
Result: findings showed mindfulness negatively predict Cognitive fusion and test anxiety (P>  0.01). Also mindfulness could indirectly predict test anxiety with the mediating role of Cognitive fusion (P > 0.01).
Conclusion: The findings of this study represent the importance of mindfulness and Cognitive fusion in explaining the test anxiety and Cognitive fusion has a mediating role between mindfulness and test anxiety. Thus In order to reduce psychological-educational problems (Such as test anxiety), Mindfulness skills training courses can be held.
Designing a Third Generation University Model with a Combined Approach in Islamic Azad Universities of Medical Sciences
Authors: Toushmali Gh , Alimohammadzadeh Kh , Maher A , Hoseini S M , Bahadori M K
Published: March 2020

Introduction: Universities have undergone various stages in their evolutionary development. At the heart of these developments is the debate on academic entrepreneurship under the auspices of a third generation university. The theoretical and practical importance of the subject on the one hand and the  lack of  infrastructure studies in third generation universities in the country have led to a fundamental study in the design of a third generation native university model.
Methods: In this study, a mixed method based approach was used. In the first step, the content analysis method was used to analyze specialized interviews, and in the second step, a final model was presented using structural-interpretive method. Data analysis was performed in qualitative phase with MAXQDA software and in quantitative phase with MICMAC software. The statistical population of this study includes experts of Islamic Azad University of Medical Sciences who were selected by purposeful sampling. The data collection tool was interview and questionnaire. To achieve the research objectives, a set of applied indicators were identified by analyzing interviews with experts.
Result: The main themes of this research are fundraising, innovation, technological entrepreneurship management and professors' entrepreneurial approach. Then, these factors were analyzed using interpretive-structural modeling techniques, and eventually the relationship and sequence of indices were obtained. Due to the leveling of the final model of the third generation university was designed in Islamic Azad University of Medical Sciences.
Conclusion: Based on this pattern, entrepreneurial organizational culture is at the heart of the model. To achieve the ultimate goals of the model, emphasis must be placed on the general level of Students entrepreneurial skills and activities, Students theoretical skills, entrepreneurial knowledge of professors, the culture of accepting new ideas and projects, the realization of knowledge-based development and commercialization of science, and the establishment of knowledge-based companies..
Reasons for Classes Irregularity at the Beginning of Each Semester from the Viewpoint of Faculty Members
Authors: Tirgar A , Mousavie Anijdan S H , Pouyakian M , Javanshir Kh , Aghalari Z
Published: March 2020

Introduction: Holding classes based on a university-set date is a form of discipline and compliance with educational regulations. But what we currently observe is one or more weeks of delay in starting the semester. This study aimed to determine the causes of irregularities at the beginning of each semester in medical universities from the viewpoint of faculty members.
Methods: This cross-sectional descriptive study was conducted in 2016, using the available sampling method on 59 faculty members of three Universities of Medical Sciences (Babol, Shahid Beheshti and Iran). The research tool was a 22-item questionnaire consisting of four sections on factors affecting irregularities. The validity of the research tool was confirmed by six faculty members and its reliability was confirmed by the test-retest method (r = 0.82).
Result: The majority of faculty members participating in the study were male (34 people), most of them were assistant professors (23 people) with the average work experience of 15.24±8.6 years. Asking them about the reasons for the students' absence showed that they believed the most important reason was their friends persuading them not to attend the first classes of each semester (4.29±0.773) and the lack of facilities such as dormitory and dining room at the beginning of the semester (3.74±1.28).
Conclusion: According to the findings, the occurrence of irregularities at the beginning of university semesters is influenced by various factors, especially encouraging classmates not to attend the classes, but the teachers can prevent it with their desired influence.
Empowering Nurses: Explaining the Role of Organizational Learning and the Dynamics of the Learning Environment
Authors: Hosseini M. H , Soleimanpour M , Mohammadi D , Norouzi ajirloo R
Published: March 2020

Introduction: Researchers acknowledge that different educational and contextual factors can influence human resource development. Because of stress in hospital wards environment and lack of personnel’s support for student, personnel’s aggressive tempers, the supporting of nursing students is an important factor. Therefore, The present study aims to investigate the role of educational environment dynamics in the relationship between organizational learning and empowerment of nurses.
Methods: With respect to study goal the research method is descriptive and correlational in terms of purpose and method of data collection. The statistical population of the study consisted of 582 nursing students in Isfahan University of Medical Sciences in the academic year of 2017-2018. Using the Morgan table and random stratified sampling, 232 students were selected. The research tool was three questionnaires that the validity and reliability of the tool were confirmed by content validity and Cronbach's alpha. Collected data were analyzed using descriptive and inferential statistics, structural equation method and SPSS 23 and Smart PLS 2 software.
Result: Findings indicate that organizational learning affects the dynamics of nurses' educational environment and empowerment. The dynamics of the educational environment has a significant and positive impact on nurses' empowerment. The results of path analysis also showed that the dynamics of the educational environment plays a mediating role in the relationship between organizational learning and empowerment of nurses. The findings showed that 48% of the total effect of organizational learning on nurses' empowerment is mediated by the dynamics of the educational environment. Also the value of GOF = 0.69 confirms the very good fit of the research model.
Conclusion: Organizational learning leads to learning human resources and involves specific organizational behavior that is performed in the learning organization. That is, organizational learning leads to the dynamics of the nursing education and empowerment environment, which is a human resources management tool that can guide human resources to increase productivity as well as enhance the learning of the whole system, especially the educational system.
Evaluating Students’ attitudes and usage e of mobile in educational activities at Paramedical Sciences School
Authors: Meraji M , Nourouziaval R , Marouzi P , Morshedlo Z , Mahmoodian S
Published: March 2020

Introduction: Mobile learning is a new way of modern teaching method and a subset of e-learning that refers to a change in thinking about the design and planning of learning goals and environments. The purpose of this study was to investigate the attitude of students of the Medical Sciences School toward the mobile phone in educational activities and its usage.
Methods: 150 students of Mashhad School of Paramedical Sciences were investigated in this cross-sectional study in 2019-20, using a researcher-made questionnaire including three sections on student demographic information, mobile applications in education, and student attitude toward mobile phone use in educational activities. The questionnaire`s validity was obtained according to 7 experts' opinions in the field of education, and its reliability was calculated using Cronbach's alpha of 0.794. Data were analyzed by descriptive and analytical statistics using SPSS 16 software.
Result: From the investigation of 150 students of Mashhad Paramedical Sciences opinions in six educational groups indicated that students of health information technology, laboratory science, physiotherapy, ophthalmology, radiology, speech therapy, medical records, mostly used mobile phones for their educational activities respectively. The most common use of students' mobile phones at university was the use of the Internet and social networks, taking photos and videos, and the most common use in teaching activities was reading files, viewing scores, recording audio and selecting units. From the students' perspective, using mobile phones in educational activities leads to getting higher scores, doing activities faster, make better communication between teacher and student, and speeded up the learning feedback.
Conclusion: According to the results, we suggest encouraging teachers to use mobile phones in academic activities and running workshops to increase the awareness of mobile capabilities. Also educational planners, and mobile based learning programs should design educational software to promote the correct culture of mobile use in educational activities.
THE SOCIO-ECONOMIC VARIABLES INFLUENCING HOUSEHOLD CONSUMPTION IN THE RURAL FARMERS LEVEL
Authors: Marwa Taufiq , Bashir Abdul , M. Husni Thamrin K. , Azwardi  , Asngari Imam
Published: March 2020

Purpose of the study: This study investigated the socio-economic effect on household consumption of rural farmers in South Sumatera, Indonesia. Methodology: The data used were primary data obtained from an in-depth survey of 300 farmer households. The analysis method used a quantitative approach with a polynomial regression model. Main Findings: The finding showed that from the four independent variables estimated, there are three which have a significant effect on farmer household consumption: household income, number of family members, and education level of the household head. Despite changes in consumption patterns between food and non-food, the process of food diversification is an important task for the government, especially to reduce dependence on rice consumption. Applications of this study: This study was conducted in South Sumatra, Indonesia in the field of agricultural economics. This study can support development planning policies in the food sector in South Sumatra. Novelty/Originality of this study: This study focus as efforts on the policy of diversifying food consumption needs to be synergized with the development of local resource-based food products.
Dyskurs protestów kobiet w Polsce w latach 2016–2017: artystyczne wizualizacje, wokalizacje, werbalizacje
Authors: Steciąg Magdalena
Published: March 2020

Artykuł dotyczy masowych protestów publicznych kobiet, które odbyły się w latach 2016–2017 w Polsce. Zawiera próbę zaprezentowana prac artystycznych z kręgu sztuki feministycznej nawiązujących do tych wydarzeń. Analiza dyskursywna dotyczy kooperacji dwóch oddalonych od siebie na pozór dyskursów — protestów ulicznych i artystycznego — w tworzeniu reprezentacji doświadczenia zbiorowego kobiet w pamięci kulturowej. Wybrano kilka przykładów artystycznych wizualizacji, wokalizacji i werbalizacji z lat 2017–2018.
Tożsamość europejska w polskim dyskursie medialnym (2015–2018). Rekonesans
Authors: Wójcicka Marta
Published: March 2020

Ważne miejsce we współczesnym dyskursie publicznym zajmuje tzw. dyskurs tożsamościowy, dominujący w tzw. mediach tożsamościowych. W dyskursie tym we współczesnych mediach zwraca się uwagę m.in. na tzw. tożsamość europejską. Celem artykułu jest próba odpowiedzi na pytanie: jaki dyskurs tożsamościowy dotyczący tożsamości Europy kreowany jest w mediach, prezentujących różne poglądy polityczne. Analizie poddano frazę tożsamość Europy/europejska, która pojawia się w polskim dyskursie publicznym. W wyniku wstępnej analizy wskazano główne zagadnienia dotyczące tożsamości współczesnej Europy, podejmowane w dyskursie medialnym, tj. kryzys tożsamościowy, relacje między tożsamością europejską a narodową, wartości, zagrożenia dla tożsamości UE.
Krajobraz językowy polsko-czeskiego pogranicza jako przestrzeń dyskursu wielojęzyczności — analiza tablic informacyjnych z sektora publicznego
Authors: Karmowska Anna
Published: March 2020

Celem artykułu jest analiza krajobrazu językowego polsko-czeskiego pogranicza jako przestrzeni wielojęzycznych praktyk dyskursywnych. Materiał badawczy stanowią tabliczki informacyjne z sektora publicznego pochodzące z kilku miejscowości: po stronie czeskiej — z Adršpach, Náchodu i Hronova, po stronie polskiej — z Kudowy-Zdroju, Karłowa oraz Dusznik-Zdroju. Pogranicze jest rozumiane w sensie geograficzno-terytorialnym jako strefa zetknięcia się i przenikania różnych narodów i grup etnicznych, kultur i języków na terenach przygranicznych. Zmienne konfiguracje i hierarchia języków występujących na tabliczkach informacyjnych świadczą zarówno o historycznych zaszłościach, jak i aktualnej społecznej dynamice na terenie polsko-czeskiego pogranicza.
NOPowcy, szczepionkowcy, odrzańcy. Słownictwo sporu o szczepienia w Polsce
Authors: Pilińska Anna
Published: March 2020

Przedmiotem artykułu jest leksyka związana ze szczepieniami (np. ziębiolaki, NOPowcy, szczepionkowcy, antyszczepionkowcy, odrzańcy, Anioły Mengelego, ebolacy, rtęciaki). Podstawowymi źródłami materiałowymi są wypowiedzi zamieszczone na forach internetowych i grupach na portalu Facebook (ze szczególnym wyróżnieniem StopNOP i Szczepić czy NIE — racjonalnie o szczepieniach). Zgromadzony materiał liczy 146 jednostek leksykalnych zebranych w lutym 2019 roku, pochodzących z wypowiedzi członków grup i forów internetowych, które zostały opublikowane w okresie od stycznia 2017 roku do stycznia 2019 roku. Przeprowadzone badania mają charakter materiałowy i dotyczą głównie zjawisk semantyczno-funkcjonalnych. Dzięki wykonanej analizie możliwe było porównanie strategii nazewniczych używanych przez obie strony uczestniczące w sporze.
Scoping Review: Valid and Reliable Health Literacy Assessment Tools Used in Low- and Middle-Income Countries
Authors: Lee HaEun , Lori Jody R.
Published: March 2020

Background and Purpose

Despite the importance of health literacy (HL) in health outcomes, most HL assessment tools are developed and used in first world, English speaking countries, and their applicability in low and middle-income countries (LMICs) is unclear. The purpose of this review is to examine valid and reliable tools used to assess HL among people in LMICs.

Methods

A literature search of three databases was conducted with 20 final articles.

Results

Current HL assessment tools used in LMICs rely on participant's literacy and focus on measuring people's functional HL rather than reflecting the evolving definitions of HL.

Conclusions

More research needs to be conducted to better understand how people with limited literacy acquire and apply HL, and HL assessment tools need to assess various aspects of HL beyond one's functional HL.
Adaptation and Validation of the Capacity Scale for Informal Caregivers of Elderly Stroke Patients to be Used in Brazil
Authors: Dal Pizzol Fernanda Laís Fengler , Predebon Mariane Lurdes , Day Carolina Baltar , Bierhals Carla Cristiane Becker Kottwitz , Machado Diani Oliveira , Aires Marines , Mahmud Sati Jaber , Rosset Idiane , Paskulin Lisiane Manganelli Girardi
Published: March 2020

Background and Purpose

The Portuguese instrument for informal caregivers' skills providing care of aged people after a stroke (ECPICID-AVC) evaluates the capacities that informal caregivers must have for supporting aged stroke survivors. The purpose was to adapt and validate the ECPICID-AVC to be used in Brazil.

Methods

A methodological study was conducted.

Results

The terms with the lowest degree of comprehension were adapted. The factor analysis suggested the exclusion of three items and that the remaining be grouped into six domains. The factor loadings varied from 0.525 to 0.924. The internal intra-assessor consistency was satisfactory (ICC = 0.94, CI 95%). Total reliability was considered excellent (Cronbach's alpha = 0.914).

Conclusions

The ECPICID-AVC is considered appropriate for using in Brazil.
Meeting Or Beating Analysts’ Revenue Forecasts Using Advertising Activities
Authors: Son Dong Hyun
Published: March 2020

This paper investigates the relationship between the likelihood of accomplishing the revenue expectations and the use of firms’ advertising expenditures depending on firms’ growth properties. First, using the analysts’ revenue forecasts as a proxy of revenues expected by market participants, the test shows that growth firms spend more resources in their advertising activities to boost up their reported revenues than non-growth firms do. The paper also examines whether the effect of the interaction between the growth properties of firms and the use of advertising expenses on the probability of achieving analysts’ revenue forecasts can vary conditionally on firms’ business strategies. Empirical results display that the positive relation between growth firms and the probability of meeting or exceeding analysts’ revenue forecasts are statistically significant for cost leadership firms but not for differentiation firms. These findings suggest that unlike differentiators, cost leaders with growth properties are more likely to achieve favorable revenue surprises through advertising activities.
“Ahlat Ağacı”nın Gölgesinde, Kentin ve Taşranın Ötesinde: Modern Gündelik Yaşamda Bıkkınlık Ruh Halinin Yükselişi
Authors: DEMİR Sertaç Timur
Published: March 2020

Bu çalışma modern kültürün bir uzantısı ve gündelik yaşamın olağan bir dışavurumuna dönüşen bıkkınlık (blasé attitude) sorunsalına odaklanmaktadır. İlk kez Georg Simmel tarafından daha çok kent yaşamına özgü mekânsal bir durum olarak tanımlanan bıkkınlık, bu makalede ise kentin sınırlarına indirgenemeyen genel bir insanlık durumu olarak ele alınmaktadır. Melankoliye kıyasla yıkıcı doku taşıyan bıkkınlık tavrı, bu çalışmada Türk yönetmen Nuri Bilge Ceylan yönettiği Ahlat Ağacı (2018) filminin karakterleri üzerinden tartışılmaktadır. Bir yöntem olarak bu sinemasal izdüşüm, gri, depresif ve karamsar bir duygulanım olan bıkkınlık meselesini yetkin bir şekilde inceleme imkânı sunmaktadır. Ceylan’ın filmlerinden görüldüğü üzere, modern birey artık yalnızca öteki ile değil; kendi varlıkları, vicdanları ve verili değerlerle karşı karşıyadır. Dahası, taraflar arasında açık bir hesaplaşma da söz konusu değildir. Bıkkınlığı kent ve taşra kültürlerinin ötesinde bireysel düzeyde tecrübe edilen bir toplumsal vakıa olarak inceleyen bu makale, bıkkınlığa temelde bir modern insan katastrofisi olarak yaklaşmaktadır.
Pernyataan Politik Sebagai Unwritten Treaty Dalam Hukum Internasional
Authors: Pradhipta Rama Surya
Published: March 2020

Dalam hubungan antar negara dalam prakteknya selalu menimbulkan konflik dan sengketa. Untuk menyikapi permasalah tersebut, negara mengeluarkan sebuah pernyataan politik. Pernyataan politik ini merupakan bentuk pernyataan sikap oleh negara terkait konflik atau sengketa. Dari pernyatan politik ini, negara yang berkonflik atau negara lainnya akan menentukan sikap, apakah menganggap pernyataan tersebut sekedar pernyataan politik saja ataukah sebagai bentuk kesepakatan negara yang bersangkutan terhadap suatu peristiwa, keadaan atau hubungan hukum tertentu. Apabila pernyataan politik tersebut dapat menciptakan suatu akibat hukum tertentu, maka dapat dikatakan bahwa pernyataan politik itu sebagai suatu perjanjian internasional. Dari fakta diatas, dapat dikatakan bahwa perjanjian internasional tidak hanya berbentuk tertulis saja, namun bisa berupa perjanjian tidak tertulis.
Hubungan Tingkat Kejadian Efek Samping Antiinflamasi Non Steroid dengan Usia dan Jenis Kelamin
Authors: Idacahyati Keni , Nofianti Tita , Aswa Geby Alinda , Nurfatwa Maritsa
Published: March 2020

Pendahuluan: Non steroid antiinflamasi drugs (NSAIDs) digunakan dalam mengatasi nyeri kronis dan inflamasi. NSAIDs menurunkan produksi prostaglandin dan prostasiklin dengan cara menghambat enzim siklooksigenase 1 dan siklooksigenase 2. Efek samping NSAIDs dapat menyebabkan gangguan di gastrointestinal, penyakit kardiovaskular, dan gangguan fungsi ginjal. Tujuan: Penelitian ini bertujuan untuk mengetahui kejadian adverse drug reaction obat golongan NSAIDs dan melihat hubungan antara kejadian ADR dengan usia dan jenis kelamin pada pasien swamedikasi di Kota Tasikmalaya. Metode: Penelitian ini dilakukan secara observasional dan prospektif yang dilakukan di 2 Apotek Kota Tasikmalaya pada bulan Februari - Mei 2019. Metode purposif sampling dilakukan untuk pengambilan sampel dengan jumlah sampel 52 responden. Instrumen pengambilan data menggunakan Algoritma Naranjo untuk mengidentifikasi apakah terdapat hubungan antara gejala klinik yang tidak diinginkan dengan obat yang digunakan menggunakan kuesioner untuk mendapatkan skor probabilitas . Kriteria inklusi dalam penelitian ini adalah responden yang mengkonsumsi NSAIDs dengan usia lebih dari 18 tahun, kriteria eksklusi adalah wanita hamil dan responden dengan penggunaan obat golongan NSAIDs menggunakan resep dokter. Analisis data secara statistik menggunakan uji korelasi Spearman. Hasil: Hasil penelitian menunjukan dari 52 pasien swamedikasi terdapat 13 orang (25%) mengalami ADR obat golongan NSAIDs berupa mual, sakit di bagian lambung, tekanan darah meningkat dan melena. Hasil analisis statistik menunjukan terdapat hubungan kuat antara kejadian ADR dengan usia  (p = 0,001) dan tidak adanya hubungan antara kejadian ADR dengan jenis kelamin (p = 0,155) (OR: 0,657). Kesimpulan: ADR yang terjadi pada responden berhubungan dengan usia tetapi tidak terdapat hubungan dengan jenis kelamin.
Analisis Kualitatif Sakarin dan Silamat pada Es Doger di Kota Batam
Authors: Marliza Hesti , Mayefis Delladari , Islamiati Raihani
Published: March 2020

Pendahuluan: Pemanis sintetis merupakan suatu zat/bahan yang digunakan untuk menimbulkan rasa manis dengan jumlah kalori yang lebih rendah daripada gula pasir. Salah satu pemanis buatan yang sering digunakan adalah sakarin dan siklamat. Konsumsi sakarin dan siklamat dalam dosis tinggi dapat menyebabkan kanker, dan penyakit lainnya seperti tumor paru, hati, limfa, migraine dan sakit kepala. Tujuan: Penelitian ini bertujuan untuk mengetahui kandungan sakarin dan siklamat pada es doger yang dijual di beberapa lokasi di Kota Batam. Metode: Penelitian ini menggunakan metode eksperimental dengan metode pengambilan sampel yang kebetulan ada atau tersedia saat itu sebanyak 12 sampel dari 12 pedagang es doger. Identifikasi sampel dilakukan secara kualitatif dengan uji pengendapan dan uji reaksi warna. Hasil: Hasil uji menunjukkan bahwa sebanyak 12 sampel dari 12 pedagang di beberapa lokasi di  Kota Batam tidak mengandung sakarin dan siklamat. Kesimpulan: Es doger yang dijual di Kota Batam tidak mengandung pemanis buatan.
Classification-Based Regression Models for Prediction of Mechanical Properties of Roller Compacted Concrete Pavement
Authors: Ashrafian Ali , Taheri Amiri Mohammad Javad , Asadi-shiadeh Mahsa , Yaghoobi-chenari Isa , Mosavi Amir , Nabipour Narjes
Published: March 2020

In the field of pavement engineering, the determination of the mechanical characteristics is one of the essential process for reliable material design and highway sustainability. Early determination of mechanical characteristics of pavement is highly essential for road and highway construction and maintenance. Tensile strength (TS), compressive strength (CS) and flexural strength (FS) of roller compacted concrete pavement (RCCP) are very crucial characteristics as they are necessitated for many data from mixture proportions as input variables. In this research, the classification-based regression models named Random Forest (RF), M5rule model tree (M5rule), M5prime model tree (M5p) and Chi-square Automatic Interaction Detection (CHAID) are developed for simulation of the mechanical characteristics of RCCP. A comprehensive and reliable dataset comprising 621, 326 and 290 data records for CS, TS and FS experimental cases extracted from several open sources over the literature. The mechanical properties are developed based on influential inputs combination that processed using Principle Component Analysis (PCA). The applied PCA method as feature selection is specified that volumetric/weighted content forms of experimental variables (e.g., coarse aggregate, fine aggregate, supplementary cementitious materials, water and binder) and specimens’ age are the most effective inputs to generate the better performances. Several statistical metrics are measured to evaluate proposed classification-based regression models. RF model revealed an optimistic classification capacity of the CS, TS and FS prediction of the RCCP in comparison with the CHAID, M5rule, and M5p models. The research is extended for the results verification using Monte-carlo model for the uncertainty and sensitivity of variables importance analysis. Overall, the proposed methodology indicated a reliable soft computing model that can be implemented for the material engineering construction and design.
Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation
Authors: Dematteis Giulia , Restelli Elena , Chiesa Roberto , Aronica Eleonora , Genazzani Armando A , Lim Dmitry , Tapella Laura
Published: March 2020

Alterations in the expression of glutamate/aspartate transporter (GLAST) have been associated with several neuropathological conditions including Alzheimer’s disease and epilepsy. However, the mechanisms by which GLAST expression is altered are poorly understood. Here we used a combination of pharmacological and genetic approaches coupled with quantitative PCR and Western blot to investigate the mechanism of the regulation of GLAST expression by a Ca2+/calmodulin-activated phosphatase calcineurin (CaN). We show that treatment of cultured hippocampal mouse and fetal human astrocytes with a CaN inhibitor FK506 resulted in a dynamic modulation of GLAST protein expression, being downregulated after 24-48 h, but upregulated after 7 days of continuous FK506 (200 nM) treatment. Protein synthesis, as assessed by puromycin incorporation in neo-synthesized polypeptides, was inhibited already after 1 h of FK506 treatment, while the use of a proteasome inhibitor MG132 (1 μM) shows that GLAST protein degradation was only suppressed after 7 days of FK506 treatment. In astrocytes with constitutive genetic ablation of CaN both protein synthesis and degradation were significantly inhibited. Taken together, our data suggest that, in cultured astrocytes, CaN controls GLAST expression at a posttranscriptional level through regulation of GLAST protein synthesis and degradation.
Improved Rapid Visual Earthquake Hazard Safety Evaluation of Existing Buildings Using Type-2 Fuzzy Logic Model
Authors: Harirchian Ehsan , Lahmer Tom
Published: March 2020

Rapid Visual Screening (RVS) is a procedure that estimates structural scores for buildings and prioritize their retrofit and upgrade requirements. Despite the speed and simplicity of RVS, many of the collected parameters are non-commensurable and include subjectivity due to visual observations. It might cause uncertainties in the evaluation, which emphasizes the use of a fuzzy-based method. This study aims to propose a novel RVS methodology based on the interval type-2 fuzzy logic system (IT2FLS) to set the priority of vulnerable building to undergo detailed assessment while covering uncertainties and minimizing their effects during evaluation. The proposed method estimates the vulnerability of a building, in terms of Visual Damage Index, considering the number of stories, age of building, plan irregularity, vertical irregularity, building quality, and peak ground velocity, as inputs with a single output variable. Applicability of the proposed method has been investigated using a post-earthquake damage database of 28 reinforced concrete buildings from the Bingöl earthquake in Turkey.
Fiber-Reinforced Cement Paste Composites for Better Sustainability
Authors: Hanafi Mohamad , Aydin Ertug , Ekinci Abdullah
Published: March 2020

Extinction of natural resources builds up pressure on governments to invest in research to find more sustainable resources for construction sector. Earlier studies on mortar and concrete show that bottom ash and basalt fiber are independently alternative binder in the concrete sector. This study aims to use bottom ash and basalt fiber blends as alternative novel-based composites in pure cement paste. Strength and durability properties of two different percentages of bottom ash (40% and 50%) and three volume fractions of basalt fiber (0.3%, 0.75%, and 1.5%) were used at three curing periods (7, 28, and 56 days). In order to measure physical properties of the basalt-reinforced bottom ash cement paste composites flowability, dry unit weight, porosity and water absorption measurements at 7, 28, and 56 days of curing were performed. Furthermore, mechanical properties of composites determined by unconfined compressive strength and flexural strength tests. Finally, to assess the durability sulfate-resistance and seawater-resistance tests have been performed on composites at 28 and 56 days of curing. Results showed that addition of basalt fiber improves physical, mechanical and chemical stability properties of paste up to a limiting basalt fiber addition (0.3% volume fraction) where above an adverse effect have been monitored. It is clear that observed results can lead to development of sustainability strategies in the concrete industry by utilizing bottom ash and basalt fiber as an alternative binder.
Prediction of Potential 3CLpro-Targeting Anti-SARS-CoV-2 Compounds from Chinese Medicine
Authors: Sun Ning , Wong Wing-Leung , Guo Jiao
Published: March 2020

The recent outbreak of coronavirus disease 2019 caused by the new coronavirus, SARS-CoV-2, has become an international emergency. Since there is no effective therapy for the treatment of this disease, drugs or vaccine that can prevent or cure the SARS-CoV-2 infection are urgently needed. The viral 3-chymotrypsin-like cysteine protease (3CLpro), which plays a key role in the replication of coronavirus, is a potential drug target for the development of anti-SARS-CoV-2 drugs. With the crystal structure of 3CLpro, we performed virtual screening from a small chemical library of a Traditional Chinese Medicine recipe- FuFang Zhenzhu Tiaozhi (FTZ). Five compounds with the best scores were screened and could be considered as potential hit compounds to be investigated further with bioassays for their anti-virus effects.
Machine Learning Algorithm’s Measurement and Analytical Visualization of User’s Reviews for Google Play Store
Authors: Karim Abdul , Azhari Azhari , Belhaouri Samir Brahim , Qureshi Ali Adil
Published: March 2020

The fact is quite transparent that almost everybody around the world is using android apps. Half of the population of this planet is associated with messaging, social media, gaming, and browsers. This online marketplace provides free and paid access to users. On the Google Play store, users are encouraged to download countless of applications belonging to predefined categories. In this research paper, we have scrapped thousands of users reviews and app ratings. We have scrapped 148 apps’ reviews from 14 categories. We have collected 506259 reviews from Google play store and subsequently checked the semantics of reviews about some applications form users to determine whether reviews are positive, negative, or neutral. We have evaluated the results by using different machine learning algorithms like Naïve Bayes, Random Forest, and Logistic Regression algorithm. we have calculated Term Frequency (TF) and Inverse Document Frequency (IDF) with different parameters like accuracy, precision, recall, and F1 and compared the statistical result of these algorithms. We have visualized these statistical results in the form of a bar chart. In this paper, the analysis of each algorithm is performed one by one, and the results have been compared. Eventually, We've discovered that Logistic Regression is the best algorithm for a review-analysis of all Google play store. We have proved that Logistic Regression gets the speed of precision, accuracy, recall, and F1 in both after preprocessing and data collection of this dataset.
Physical, Mechanical and Durability Performance of Pastes Containing Carbon Fiber
Authors: Atiyeh Mohamad , Aydin Ertug
Published: March 2020

The damage caused by global warming is rapidly increasing, and its adverse effects become more evident with each passing day. Although it is known that the use of alternative binder materials in concrete would decrease this negative effect, reluctance to new composites continues. Waste use plays a vital role in sustainability studies. In this study, pure cement paste was prepared and enriched with carbon fiber. This study investigated the wide range of volume fraction of carbon fiber in cement-based composites. Two different industrial wastes, marble dust, and bottom ash were chosen and mixed with cement and four different (0.3%, 0.75%, 1.5%, and 2.5%) carbon fiber volume fractions. Based on physical, mechanical, and durability tests at 7, 28, and 56-days of curing, the composites were resistant to sulfate and seawater attack. The 0.75% carbon fiber addition seems to be an optimum volume percentage beyond which both physical and mechanical properties were adversely affected. The composites with 0.75% carbon fiber have reached 48.4 MPa and 47.2 MPa at 56-days of curing for marble dust and bottom ash mixture groups, respectively.
Impact of Use of Gastric-Acid Suppressants and Oral Anticancer Agents on Survival Outcomes: A Systematic Review and Meta-Analysis
Authors: Indini Alice , Petrelli Fausto , Tomasello Gianluca , Rijavec Erika , Facciorusso Antonio , Grossi Francesco , Ghidini Michele
Published: March 2020

We performed a systematic review and meta-analysis to evaluate the role of gastric acid suppressant use on outcomes of tyrosine kinase inhibitors (TKIs) and oral chemotherapy. We identified all researches evaluating the effect of GAS use on patients receiving oral chemotherapy or TKIs for solid tumors. The pooled hazard ratios (HRs) and 95% confidence interval (95% CI) for overall survival (OS) and progression-free survival (PFS) were calculated with fixed-effects or random-effects model. The study population included n=16 retrospective studies and 372,418 patients. Series concerned gastrointestinal tract tumors (n=5 studies), renal cell carcinomas (RCC, n=3 studies), non-small cell lung cancers (NSCLC, n=5 studies), and soft tissue sarcomas or mixed histologies solid tumors in n=3 studies. The pooled HRs for OS and PFS were 1.31 (95% CI: 1.20–1.43; P<01) and 1.3 (95%CI 1.07-1.57; P<0.01) for GAS and no GAS users, respectively. Only studies of EGFR mutated NSCLC patients receiving TKIs and those with colorectal cancer receiving oral chemotherapy showed a significant correlation between GAS and poor survival. Our study supports the evidence of a possible negative impact of concomitant GAS therapy on survival outcomes of patients receiving oral anti-cancer drugs.
Inflammatory Responses during Tumour Initiation: From Zebrafish Transgenic Models of Cancer to Evidence from Mouse and Man
Authors: Elliot Abigail , Myllymäki Henna , Feng Yi
Published: March 2020

The zebrafish is now an important model organism for cancer biology studies and provides some unique and complementary opportunities in comparison to the mammalian equivalent. The translucency of zebrafish has allowed in vivo live imaging studies of tumour initiation and progression at the cellular level thus providing novel insights into our understanding of cancer. Here we summarise and discuss available transgenic zebrafish tumour models and what we have gleaned from them with respect to cancer inflammation. In particular, we focus on the host inflammatory response toward transformed cells during the pre-neoplastic stage of tumour development. We discuss features of tumour associated macrophages and neutrophils in mammalian models and present evidence which supports the idea that these inflammatory cells promote early stage tumour development and progression. Direct live imaging of tumour initiation in zebrafish models has shown that the intrinsic inflammation induced by pre-neoplastic cells is tumour promoting. Signals mediating leukocyte recruitment to pre-neoplastic cells in zebrafish correspond to signals mediating leukocyte recruitment in mammalian tumours. The activation state of macrophages and neutrophils recruited to pre-neoplastic cells appears to be heterogenous, as seen in mammalian models, which provides an opportunity to study the plasticity of innate immune cells during tumour initiation. Although several potential mechanisms are described that might mediate the trophic function of innate immune cells during tumour initiation in zebrafish, there are several unknowns that are yet to be resolved. Rapid advancement of genetic tools and imaging technologies for zebrafish will facilitate research into the mechanisms that modulate leukocyte function during tumour initiation and identify targets for cancer prevention.
Impact of NPS MedicineWise general practitioner education programs and Choosing Wisely Australia recommendations on prescribing of proton pump inhibitors in Australia
Authors: Wu Jianyun , Dickinson Scott , Elgebaly Zain , Blogg Suzanne Gaye , Heaney Aine , Soo Yien , Daniels Benjamin , Weekes Lynn
Published: March 2020

Background: This study evaluated the impact of multifaceted NPS MedicineWise programs conducted in 2009 and 2015 that targeted general practitioners (GPs) to reduce unnecessary prescribing of proton pump inhibitors (PPIs).
Methods: Time series analyses was conducted of the dispensing rates of concessional PPI scripts between January 2006 and June 2016 using the Pharmaceutical Benefits Scheme (PBS) and Medicare Benefits Schedule (MBS) databases in Australia. Participants were GPs with dispensed PPI prescriptions to concessional patients between January 2006 and June 2016. The interventions were national NPS MedicineWise PPI educational programs in 2009 and 2015 delivered to all practising GPs in Australia. The 2015 intervention coincided with the release of Choosing Wisely Australia recommendations from the Royal Australian College of General Practitioners (RACGP). Outcome measures included monthly dispensing rates of high/standard and low strength PPIs prescribed by GPs among concessional patients in Australia.
Results : Following the 2009 NPS MedicineWise program we observed a 6.7% reduction in the expected dispensing rate of standard strength PPIs among concessional patients between January 2006 and March 2015, and a total 8.6% reduction by June 2016 following the launch of the 2015 program. We observed a significant increase of 5.6% in the dispensing rate of low strength PPIs among concessional patients between April 2009 and March 2015, and no significant change in trend following the 2015 program.
Conclusions: The NPS MedicineWise programs were associated with reductions in the dispensing rate of high/standard strength PPIs and with an increase in the dispensing rate of low-strength PPIs by June 2016 although a causal relation was not confirmed. Although the rate of high/standard strength PPI prescribing is declining, these formulations still constitute the majority of PPIs used in Australia. Regular interventions to sustain and improve PPI management by GPs may be warranted.
Healthcare Utilization and Out-of-Pocket Expenditures Associated with Depression in Adults: A Cross-Sectional Analysis in Nepal
Authors: Rajan Selina , Rathod Sujit D , Luitel Nagendra P , Murphy Adrianna , Roberts Tessa , Jord Mark JD
Published: March 2020

Background:
Despite attempts to improve universal health coverage (UHC) in low income countries like Nepal, most healthcare utilization is still financed by out-of-pocket (OOP) payments, with detrimental effects on the poorest and most in need. Evidence from high income countries shows that depression is associated with increased healthcare utilization, which may lead to increased OOP expenditures, placing greater stress on families. To inform policies for integrating mental healthcare into UHC in LMIC, we must understand healthcare utilization and OOP expenditure patterns in people with depression. We examined associations between symptoms of depression and frequency and type of healthcare utilization and OOP expenditure among adults in Chitwan District, Nepal.
Methods:
We analysed data from a population-based survey of 2040 adults in 2013, who completed the PHQ-9 screening tool for depression and answered questions about healthcare utilization. We examined associations between increasing PHQ-9 score and healthcare utilization frequency and OOP expenditure using negative binomial regression. We also compared utilization of specific outpatient service providers and their related costs among adults with and without probable depression, determined by a PHQ-9 score of 10 or more.
Results:
We classified 80 (3.6%) participants with probable depression, 70.9% of whom used some form of healthcare in the past year compared to 43.9% of people without probable depression. Mean annual OOP healthcare expenditures were $118 USD in people with probable depression, compared to $110 USD in people without. With each unit increase in PHQ-9 score, there was a 14% increase in total healthcare visits (95% CI 7%-22%, p<0.0001) and $9 USD increase in OOP expenditures (95% CI $2-$17; p<0.0001). People with depression sought most healthcare from pharmacists (30.1%) but reported the greatest expenditure on specialist doctors ($36 USD).
Conclusions:
In this population-based sample from Central Nepal, we identified dose-dependent increases in healthcare utilization and OOP expenditure with increasing PHQ-9 scores. Future studies should evaluate whether provision of mental health services as an integrated component of UHC can improve overall health and reduce healthcare utilisation and expenditure, thereby alleviating financial pressures on families.
WITHDRAWN: Successful implementation of an Enhanced Recovery After Surgery (ERAS) protocol reduces nausea and vomiting in patients after infratentorial craniotomy for tumour resection: a randomized controlled trial.
Authors: Author) Dan Lu(Former Corresponding , Wang Yuan , Zhao Tianzhi , Liu Bolin , Ye Lin , Zhao Lanfu , Zhao Binfang , Li Mingjuan , Ma Lin , Li Zhengmin , Niu Jiangtao , Lv Wenhai , Zhang Yufu , Zheng Tao , Xue Yafei , Chen Lei , Chen Long , Sun Xude , Gao Guodong , Chen Bo , Author) Shiming He(New Corresponding
Published: March 2020

Objectives : Infratentorial craniotomy patients have a high incidence of postoperative nausea and vomiting (PONV). Enhanced Recovery After Surgery (ERAS) protocols have been shown in multiple surgical disciplines to improve outcomes, including reduced PONV. However, very few studies have described the application of ERAS to infratentorial craniotomy. The aim of this study was to examine whether our ERAS protocol for infratentorial craniotomy could improve PONV. Methods : We implemented an evidence-based, multimodal ERAS protocol for patients undergoing infratentorial craniotomy. A total of 105 patients who underwent infratentorial craniotomy were randomized into either the ERAS group (n = 50) or the control group (n = 55). Primary outcomes were the incidence of vomiting, nausea score, and use of rescue antiemetic during the first 72 h after surgery. Secondary outcomes included postoperative anxiety level, sleep quality, and complications. Results: Over the entire 72 h post-craniotomy observation period, the cumulative incidence of vomiting was significantly lower in the ERAS group than in the control group. Meanwhile, the incidence of vomiting was significantly lower in the ERAS group on postoperative days (PODs) 2 and 3. Notably, the proportion of patients with mild nausea (VAS 0-4) was higher in the ERAS group as compared to the control group on PODs 2 or 3. Additionally, the postoperative anxiety level and quality of sleep were significantly better in the ERAS group. Conclusion: Successful implementation of our ERAS protocol in infratentorial craniotomy patients could attenuate postoperative anxiety, improve sleep quality, and reduce the incidence of PONV, without increasing the rate of postoperative complications.