bluuebunny/crossref_metadata_2025 huggingface dataset:
Negative pressure wound therapy in reconstructing extensive leg and foot soft tissue loss in a child: a case study
Authors: Tevanov Iulia , Enescu Dan Mircea , Carp Madalina , Dusca Andrei , Ladaru Alin , Ulici Alexandru
Published: June 2018

Open fractures of the leg with large loss of tissue require extensive reconstructive methods that can injure the donor area. The use of negative pressure wound therapy (NPWT) may minimise the impact of these reconstructive methods because of its capacity to create granulation tissue that will form a wound bed for the skin graft, thus reducing the volume of soft tissue defect and saving the donor region. This case study describes the effectiveness of NPWT in the treatment and reconstruction of an open fracture of the leg, with massive loss of soft tissue, associated with elastic intramedullary nailing in a 10-year-old female patient, who was a victim of a car accident. Clinical examination revealed a Gustilo-Anderson IIIB open fracture of the left leg, with the avulsion of the fifth toe, disarticulation of the fifth metatarsal bone, extensively damaged skin and subcutaneous tissue in the medium and distal third of the left leg and left foot. The bone was exposed in the distal part of the leg, external malleolus and left calcaneus. Profuse lavage, reduction of the tibial fracture and elastic intramedullary nailing, amputation of the fifth left toe, necrectomy and debridement of devitalised tissue were performed. NPWT was started, with the dressing changed every five days. After 55 days of using NPWT, granulation tissue covered the soft tissue defect and created a wound bed for the skin graft. NPWT helped the management of this open wound, achieving a wound bed for the skin graft, avoiding the use of complex reconstructive methods.
Marker free model-based radiostereometric analysis for evaluation of hip joint kinematics
Authors: Hansen L. , De Raedt S. , Jørgensen P. B. , Mygind-Klavsen B. , Kaptein B. , Stilling M.
Published: June 2018

Objectives

To validate the precision of digitally reconstructed radiograph (DRR) radiostereometric analysis (RSA) and the model-based method (MBM) RSA with respect to benchmark marker-based (MM) RSA for evaluation of kinematics in the native hip joint.

Methods

Seven human cadaveric hemipelves were CT scanned and bone models were segmented. Tantalum beads were placed in the pelvis and proximal femoral bone. RSA recordings of the hips were performed during flexion, adduction and internal rotation. Stereoradiographic recordings were all analyzed with DRR, MBM and MM. Migration results for the MBM and DRR with respect to MM were compared. Precision was assessed as systematic bias (mean difference) and random variation (Pitman’s test for equal variance).

Results

A total of 288 dynamic RSA images were analyzed. Systematic bias for DRR and MBM with respect to MM in translations (p < 0.018 mm) and rotations (p < 0.009°) were approximately 0. Pitman’s test showed lower random variation in all degrees of freedom for DRR compared with MBM (p < 0.001).

Conclusion

Systematic error was approximately 0 for both DRR or MBM. However, precision of DRR was statistically significantly better than MBM. Since DRR does not require marker insertion it can be used for investigation of preoperative hip kinematics in comparison with the postoperative results after joint preserving hip surgery.  Cite this article: L. Hansen, S. De Raedt, P. B. Jørgensen, B. Mygind-Klavsen, B. Kaptein, M. Stilling. Marker free model-based radiostereometric analysis for evaluation of hip joint kinematics: A validation study. Bone Joint Res 2018;7:379–387. DOI: 10.1302/2046-3758.76.BJR-2017-0268.R1.
Narratives of health and hospitality: Strathpeffer Spa c. 1866–c. 1949
Authors: Thomson Elaine
Published: June 2018

This article examines the history of Strathpeffer Spa (the United Kingdom’s most northerly spa) between c. 1860 and c. 1949 using a range of printed primary and archive sources. Drawing upon Hansen’s work in business history it demonstrates the value of a cultural and narrative approach as a means of understanding the development of a distinctive hospitality-based community. Strathpeffer Spa was founded for the business of health, with the entire village dependent upon the spa and engaged in the provision of hospitality for those who came to ‘take the waters’. From c. 1866 a powerful ‘health narrative’ dominated the village community. At the heart of this was an emphasis on Strathpeffer as a destination devoted to the requirements of ‘health seekers’ and ‘invalids’, and where meeting the needs of this particular clientele was paramount. Hospitality at Strathpeffer was, thus, medicalized into a prolonged health-giving experience, a narrative that was created and sustained by key members of the community, and which became deeply embedded in the fabric and purpose of the village. Although the emphasis on this ‘health narrative’ proved initially to be successful, in the longer term it became a contributing factor in Strathpeffer Spa’s declining fortunes. The value of a narrative approach for understanding the sustainability of hospitality-based communities is discussed.
Hospitality in wild places
Authors: Varley Peter , Farkic Jelena , Carnicelli Sandro
Published: June 2018

We contribute to the hospitality work research agenda by reconsidering the role of outdoor adventure guides as agents of hospitality, set against a conceptual backdrop of deepening ontological insecurity in industrialized societies. We argue that the concepts of dwelling, communitas and hygge have much to offer in the delivery of outdoor hospitality in general, and in outdoor adventure tourism scenarios in particular. Although originating from the Danes and their ideas of ‘cosy indoor life’, the concept of hygge has recently gained global attention in the debates around creating comfortable atmospheres at home, and in fostering people’s emotional well-being on holiday. Moving the concept along, we suggest the stimulation of hygge in the outdoors, along with provision of the space to dwell and the stage management of the communal effervescence of communitas as part of the crucial skill set for the outdoor guide. We opine that such conceptualization can greatly inform our understanding of both the role of the outdoor guide and of the dynamics of deliverable hospitable experience more generally.
Deteksi dan Evaluasi Keragaman Genetika Candidatus Liberibacter asiaticus sebagai Penyebab Penyakit Huanglongbing di Indonesia Berdasarkan Gen β-operon
Authors: Rizal Muhammad , Mutaqin Kikin Hamzah , Suastika Gede
Published: June 2018

Huanglongbing also known in Indonesia as citrus vein phloem degeneration (CVPD) is a devastating disease in citrus plantation worldwide, especially in Asia, Africa, and America. In Asian countries including Indonesia, Candidatus Liberibacter asiaticus (CLas) has been confirmed as the causal agent of huanglongbing disease on citrus. Distribution of CLas in Indonesia has been reported in West Borneo, East Nusa Tenggara, Bali, Yogyakarta, Central Java and East Java.  The purpose of this study was to detect CLas in several Indonesia’s citrus plantations that has not and has been reported previously and to study its genetic diversity and their relationship. DNA of plant samples, i.e. citrus leaves, was extracted using CTAB method and CLas was amplified using PCR with the A2/J5 primer pair. DNA amplification results showed that infection of CLas was positively detected from samples from Bogor and Cibodas (West Java), Tuban and Jember (East Java), as well as Katung, Bayung Gede, Kerta, and Pancasari (Bali). Alignment of nucleotide sequences from positive samples showed that their ribosomal protein β-operon has high similiarity to that of CLas OK901 originated from Okinawa (Japan). Isolates of CLas originated from Bogor, Cibodas, Tuban, Jember, and Katung have been known to be identical to other CLas of Indonesian origins reported earlier.  Isolates of CLas originated from Bayung Gede, Pancasari, and Kerta have single nucleotide polymorphisms at 6 points of bases of the 539 total bases compared in their conservative regions, although only 3 of the 6 bases could affect their amino acid sequences.
TERTIB JENIS, HIERARKI, DAN MATERI MUATAN PERATURAN PERUNDANG-UNDANGAN: PERMASALAHAN DAN SOLUSINYA
Authors: Anggono Bayu Dwi
Published: June 2018

Terdapat 2 tertib peraturan perundang-undangan yaitu tertib dasar peraturan perundang-undangan dan tertib pembentukan peraturan perundang-undangan. Praktik sistem perundang-undangan Indonesia pasca diberlakukannya UU 12/2011 menunjukkan permasalahan pada tertib dasar perundang-undangan yaitu kurang terkontrolnya jenis peraturan yang dapat digolongkan sebagai peraturan perundang-undangan, tidak semua jenis peraturan perundang-undangan jelas letaknya dalam hierarki dan terlalu luasnya materi muatan serta kesamaan materi muatan antar peraturan perundang-undangan. Upaya mewujudkan tertib peraturan perundang-undangan dapat dilakukan dengan mengeluarkan jenis peraturan lembaga yang tidak berkategori sebagai peraturan perundang-undangan, meletakkan setiap jenis peraturan perundang-undangan dalam hierarki, dan pengetatan suatu materi muatan yang dapat diatur dengan peraturan perundang-undangan, serta melakukan pembedaan secara jelas materi muatan tiap jenis peraturan perundang-undangan
Model Pengaturan Rencana Tata Ruang Wilayah Berbasis Kelautan Dan Kemaritiman Di Provinsi Maluku
Authors: La Ode Angga La Ode
Published: June 2018

This research aimed to formulate model of arrangement of maritime area planning and maritime of Maluku province as the answer from kopleksnya problem faced at this time with the ultimate goal is to minimize the conflict that arise in marine area and small islands in Maluku Province, and as input ) for the Provincial Government of Maluku in formulating policies on coastal, marine and small islands.Approach method used in this research is juridical emperis or juridical sociology which is descriptive qualitative analysis. The study attempts to describe what happens in coastal communities living around the conflicts occurring in these two research sites: Central Maluku (Malteng) and West Seram (SBB) kabuapten. Data collection techniques used in this study are: Interviews, questionnaires and literature study.The study found that the reconstruction of an ideal spatial plan arrangement model for Maluku Province should consider the characteristics of Maluku as a maritime and maritime province. Therefore, the authors undertake the reconstruction of the spatial planning model of maluku provincial area based on maritime and maritime with the addition of principles in Article 3 of the Regional Regulation. 16 of 2013 on RSP with the addition of prudential principles. Furthermore, the authors make additions in some articles so that with the addition of the article can minimize conflicts in the utilization of coastal space and marine areas in Maluku Province.
FEMINIST LEGAL THEORY DALAM TELAAH PARADIGMA: SUATU PEMETAAN FILSAFAT HUKUM
Authors: Sulistyawan Aditya Yuli
Published: June 2018

Feminist Legal Theory (FLT) is a groundbreaking thought against the enactment of the law against women. As one of the schools of thought, the distinctiveness of FLT can not be freely explained. The explanation of this will only be done precisely by the 'umbrella philosophy' called the paradigm. Through the paradigm, FLT will be placed in one paradigm, according to its ontology, epistemology, and methodology. In summary, the purpose of this paper is to create a mapping of legal philosophy to FLT. Based on the discussion, FLT can eventually be mapped as one of the flows within the Critical Theory et. al. paradigm.
PERKEMBANGAN PEMILIHAN PRESIDEN DAN WAKIL PRESIDEN DI INDONESIA
Authors: Indarja Indarja
Published: June 2018

The aim of this paper is to analyze the regulation of general election of President and vice President in Indonesia. The method used is the normative juridical, with the history approach. Based on  results that the Election of President and Vice President in Indonesia changes from time to time, from the period 1945-1950 President and Vice President elected by PPKI by acclamation. The period 1950-1959 elected by agreement between the state of RIS and RI. After the 1959 period until now, the President and Vice President were elected by the people through general elections.
KECAKAPAN HUKUM DAN LEGALITAS TANDATANGAN SEORANG TERPIDANA DALAM MENANDATANGANI AKTA OTENTIK
Authors: Wirahutama Danang
Published: June 2018

This article aims to find out and analyze the legal and legal skills of a convicted person in signing an authentic deed. Research methods used to achieve the objectives of this legal research using normative juridical approach method. The nature of the research used is a descriptive study in this study to provide arguments from the results of research conducted, because trying to find the rules of law, legal principles, and legal doctrines to further analyzed by guiding and describing the legislation that applies relating to legal theory and practice of the implementation of positive law concerning the problem in this research. The result of this research is that the legal skills of a convicted person in a penitentiary sign a notarial deed, that the convicted person undergoing punishment in a correctional institution is capable of acting in law by signing or becoming a deed before a notary. The convict is different from the suspect, even though both are involved in criminal cases. The convicted person undergo a criminal sanction after receiving a court decision that has permanent legal power. In the Notary's Office Law, the Notary is given the obligation that if the interlocutor can not affix a signature caused by paralysis, illness, or any other reason, inasmuch as a signature, the tamper may impose a fingerprint on a deed mine. This means that there is no reason for anyone in a penitentiary to undergo a criminal sanction that has a permanent legal power. If it is related to the acting skills of the law as provided in article 1330 of the Civil Code there is no mention that the person in the penal institution undergoing criminal sanction is declared incapable of acting in law, so long as he is 18 years old or has married and is not under if any person is capable of acting in law, as provided for in article 1 (3) of the Civil Code, that there is no punishment that results in civil death, or the loss of any citizenship rights.
PERLINDUNGAN HUKUM TERHADAP NELAYAN PEREMPUAN: STUDI KASUS DI KABUPATEN DEMAK, PROVINSI JAWA TENGAH
Authors: Pujirahayu Esmi Warassih , Sulaiman Sulaiman , Wijaningsih Dyah , Rahayu Derita Prapti , Untoro Untoro
Published: June 2018

Women's fishers have long been known in Indonesia. Women fishers generally take part in the processing of fishery products. The existence of women fishers is very helpful family economic conditions due to fishing activities that are determined by the time in the sea. This research wants to answer how legal protection is given to women fishers in carrying out their activities. This study uses socio-legal approach, by looking at legal aspects that can not be separated from various other aspects such as economy, politics, and socio-culture. The study found that the state has not fully protected the women fishers. The legal framework for fishing protection is not fully implemented. The limitations of various facilities have caused fishers can not get their rights as citizens. The study recommends that the district government immediately implement a fishers protection for women fishers.  Nelayan perempuan sudah lama dikenal di Indonesia. Nelayan perempuan umumnya berkiprah dalam hal pengolahan hasil perikanan. Keberadaan nelayan perempuan sangat membantu kondisi ekonomi keluarga disebabkan aktivitas nelayan yang ditentukan oleh waktu dalam melaut. Penelitian ini ingin menjawab bagaimana perlindungan hukum yang diberikan terhadap nelayan perempuan dalam melaksanakan aktivitasnya. Penelitian ini menggunakan pendekatan sosio-legal, dengan melihat aspek hukum yang tidak terlepas dari berbagai aspek lain seperti ekonomi, politik, dan sosial-budaya. Penelitian ini menemukan bahwa negara belum sepenuhnya melindungi nelayan perempuan. Kerangka hukum perlindungan nelayan belum sepenuhnya tersedia. Keterbatasan berbagai fasilitas telah menyebabkan nelayan tidak bisa mendapatkan haknya sebagai warga negara. Penelitian merekomendasikan agar pemerintah kabupaten segera melaksanakan secara utuh perlindungan nelayan terhadap nelayan perempuan.
PERTANGGUNGJAWABAN PIDANA ATAS TINDAKAN DISKRESI PEJABAT PEMERINTAHAN YANG BERINDIKASI ADANYA PENYALAHGUNAAN WEWENANG
Authors: Hulu Sabarudin
Published: June 2018

Penyelenggara pelayanan publik melakukan berbagai upaya inovasi pelayanan melalui diskresi. Perbuatan penyalahgunaan wewenang pejabat pemerintahan dalam menerbitkan diskresi, dapat menimbulkan kerugian negara dan masuk dalam kategori perbuatan korupsi yang dipertanggungjawabkan secara pidana. Pengaturan diskresi sesuai Undang-Undang Nomor 30 Tahun 2014 tentang Administrasi Pemerintahan. Penelitian ini mengambil permasalahan, bagaimana tolok ukur tindakan diskresi oleh pejabat pemerintahan dapat dikategorikan sebagai penyalahgunaan wewenang sehingga harus dipertanggungjawabkan secara pidana, dan bagaimanakah pertanggungjawaban pidana pejabat pemerintahan atas tindakan diskresi yang berindikasi adanya penyalahgunaan wewenang berdasarkan Undang-Undang Nomor 30 Tahun 2014 tentang Administrasi Pemerintahan. Dalam mencapai tujuan penelitian, maka metode penelitian yang digunakan adalah metode yuridis normative dengan pendekatan deskriptif analitis. Metode pengumpulan data yang digunakan adalah kepustakaan baik secara umum maupun teori yang dianalisis dan dideskripsikan untuk memberikan gambaran yang konkrit. Hasil penelitian disimpulkan, bahwa diskresi Pejabat Pemerintahan dapat dinyatakan terjadi penyalahgunaan wewenang apabila pengambilan diskresi tidak sesuai syarat dan batasan yang diatur dalam Undang-Undang Nomor 30 Tahun 2014 tentang Administrasi Pemerintahan dan Asas-Asas Umum Pemerintahan Yang Baik. Kewenangan Pengadilan Tata Usaha Negara dan Inspektorat sebagai Aparat Pengawasan Intern Pemerintah, dibatasi oleh Peraturan Mahkamah Agung Nomor 4 Tahun 2015 tentang Pedoman Beracara Dalam Penilaian Unsur Penyalahgunaan Wewenang. Oleh karena itu, perlu melakukan perubahan terhadap Peraturan Pemerintah Nomor 48 Tahun 2016 tentang tata cara pengenaan sanksi administratif kepada pejabat pemerintahan, untuk mengatur konsekuensi hukum atas Putusan Pengadilan Tata Usaha Negara, serta mengubah Peraturan Mahkamah Agung Nomor 4 Tahun 2015 tentang Pedoman Beracara Dalam Penilaian Unsur Penyalahgunaan Wewenang, karena membatasi wewenang Pengadilan Tata Usaha Negara. Kata Kunci: Pelayanan Publik, Diskresi, Korupsi.
URGENCY OF BUMN HOLDING IN SECTOR IMPROVEMENT LAND AND AIR TRANSPORT SERVICES
Authors: Estanto Boby Wilda
Published: June 2018

Since Indonesian independence until now, state-owned enterprises have played a significant role in infrastructure development as well as the state's economy. The State conducts economic activities in the framework of the implementation of Article 33 of the 1945 Constitution. State-Owned Enterprises (BUMN) is a business entity wholly or largely owned by the state, through direct participation derived from separated state assets. If linked to the sector of land and air transport services, it can be seen from the facts in the field that the needs of public transportation is a requirement of society that continues to grow in accordance with the increasing level of community life. In this case, the service factor remains the preferred and planned in realizing consumer expectation and desires where seen in the fact that service in the field of land transportation sector and also air transportation tends to be minimal and not maximal yet. However, the availability of infrastructure is one of the vital aspects in accelerating the process of national development in various fields. The economic growth rate of a country can not be separated from the availability of infrastructure as a whole which is the foundation of sustainable economic development. Based on this matter, that in the future needed effort of holding state-owned enterprises in the framework of improving infrastructure, especially in the field of air transport and land transportation. The purpose of this writing is to describe the holding of SOEs from the perspective of law and SOE holding solutions in order to improve the service sector of land and air transport. The research method used in this study is a normative approach or a conseptual approach. The type of research used in this study is normative legal research, ie research focused on assessing the application of norms or norms in positive law regarding the holding of SOEs.
Optical Music Recognition in der Bayerischen Staatsbibliothek
Authors: Diet Jürgen
Published: June 2018

Die Bayerische Staatsbibliothek hat im Sommer 2016 ein Projekt zur automatischen Notenerkennung (Optical Music Recognition, OMR) gestartet. Dieser Beitrag beschreibt zunächst die Funktionsweise und die Qualität von OMR-Programmen und geht dann auf die bisherigen Erfahrungen der Bayerischen Staatsbibliothek mit OMR ein. Anschließend werden die Anwendungsszenarien skizziert, die die Bayerische Staatsbibliothek aufsetzend auf den OMR-Daten entwickeln wird.1
Bach digital: Ein „work in progress“ der digitalen Musikwissenschaft
Authors: Hausmann Christiane
Published: June 2018

Der Beitrag zeichnet die inhaltlich-technische Entwicklung der Komponistendatenbank Bach digital nach und erläutert ihre Zielsetzungen. Damit einhergehend werden einerseits die Herausforderungen und Probleme digitaler Langezeitprojekte benannt. Andererseits wird dargestellt, wie durch die Entwicklung eines komplexen digitalen Recherche-Instruments die Organisation und Präsentation von Forschungsergebnissen transformiert werden und welche Veränderungen sich dadurch für das musikwissenschaftliche Arbeiten und die Forschungskommunikation ergeben.
Das Internationale Quellenlexikon der Musik, RISM
Authors: Keil Klaus , Pugin Laurent
Published: June 2018

Das Internationale Quellenlexikon der Musik (RISM) ist ein internationales Gemeinschaftsprojekt mit dem Ziel, die weltweit überlieferten Quellen zur Musik umfassend zu dokumentieren. Es bietet einen Online-Katalog, der Bibliothekaren, Musikern, Wissenschaftlern und allen interessierten Personen kostenlos zur Verfügung steht. Zunehmend gerät aber der Austausch von Daten in den Vordergrund, sei es von lokalen Online- Bibliothekskatalogen zu RISM oder umgekehrt. Für die Wissenschaft dürfte die Nachnutzung der Daten, die sowohl als Open Data als auch Linked Open Data bereitstehen, in Spezialprojekten von Interesse sein.
Bibliotheken mit Vorstellungskraft – Bausteine für einen Lehrplan für zukünftige Bibliotheksarbeit
Authors: Bruijnzeels Rob , Sternheim Joyce
Published: June 2018

Um die Wissensschaffung und Interaktion in ihren Gemeinschaften zu verbessern, müssen Bibliotheken die kollektiven Kenntnisse der Menschen nutzen und deren Aktivitäten und Wissen in ihre Sammlung einbeziehen. Um dies zu erreichen, hat das niederländische Ministerium für Vorstellungskraft einen neuen Arbeitsprozess entwickelt, der die Nutzung des Bibliotheksraums berücksichtigt und zu einem neuen Lehrplan für Bibliothekare und einer neuen Typologie für öffentliche Bibliotheksgebäude führen könnte.

Die Übersetzung des vorliegenden Artikels wurde von Iris Réthy angefertigt.
Asymptotic Behavior of a Stochastic Two-Species Competition System with Impulsive Effects
Authors: Wang Pan , Li Bing , Li Yongkun
Published: June 2018

In this paper, we consider a stochastic two-species competition system with impulsive effects. Some dynamical properties are investigated and sufficient conditions for the stochastic boundedness, stochastic permanence and global attractivity are established. Under some conditions, we conclude that the stochastic model is persistent in mean and extinction. An example is given to illustrate the main result.
Existence Results of Mild Solutions for Impulsive Fractional Integrodifferential Evolution Equations With Nonlocal Conditions
Authors: Zhang Xuping , Gou Haide , Li Yongxiang
Published: June 2018

In this paper, we investigate the existence of mild solutions of impulsive fractional integrodifferential evolution equations with nonlocal conditions via the fixed point theorems and fractional cosine family combined with solutions operator theorems. Our results improve and generalize some classical results. Finally, an example is given to illustrate the main results.
Factors Affecting Acceptance of Mobile Library Applications: Structural Equation Model
Authors: Rafique Hamaad , Anwer Fozia , Shamim Azra , Minaei-Bidgoli Behrouz , Qureshi Muhammad Ahsan , Shamshirband Shahaboddin
Published: June 2018

Acceptance and intention to use mobile applications in a library context is attracting a great deal of interest in education field. A sparse amount of research was conducted in mobile library applications (MLA) previously, investigating the influential factors of intention to use MLA. Research here aims to provide empirical support on acceptance of MLA, library access through mobile applications, with the model developed by taking a technology acceptance model (TAM) in MLA context by adding perceived mobility value, system accessibility and satisfaction for investigating the influence on behavioural intention to use MLA. A self-administrated cross-sectional survey was conducted to collect data from 321 users of MLA in the COMSATS Institute of Information Technology (CIIT) in Islamabad, while a structural equation model (SEM) using analysis of moment structure (AMOS) software was used for examining quantitative data. Results revealed that satisfaction and perceived ease of use are direct significant predictors of intention to use MLA, whereas system accessibility was influenced by the perceived ease of use. However, the perceived mobility value shows a weak effect on intention to use MLA in terms of perceived usefulness. Results serve as a guide for effective decision-making in development and resource allocation to ensure the success of the library’s vision and mission.
A relaxed block splitting preconditioner for complex symmetric indefinite linear systems
Authors: Huang Yunying , Chen Guoliang
Published: June 2018

In this paper, we propose a relaxed block splitting preconditioner for a class of complex symmetric indefinite linear systems to accelerate the convergence rate of the Krylov subspace iteration method and the relaxed preconditioner is much closer to the original block two-by-two coefficient matrix. We study the spectral properties and the eigenvector distributions of the corresponding preconditioned matrix. In addition, the degree of the minimal polynomial of the preconditioned matrix is also derived. Finally, some numerical experiments are presented to illustrate the effectiveness of the relaxed splitting preconditioner.
Positive solutions of semipositone singular fractional differential systems with a parameter and integral boundary conditions
Authors: Hao Xinan , Wang Huaqing
Published: June 2018

In this paper, the existence of positive solutions for systems of semipositone singular fractional differential equations with a parameter and integral boundary conditions is investigated. By using fixed point theorem in cone, sufficient conditions which guarantee the existence of positive solutions are obtained. An example is given to illustrate the results.
Heritage Restoration as a Tool to Promote Architectural Identity in the Gulf Regions
Authors: Mazzetto Silvia
Published: June 2018

Recently most of the Gulf countries have had significant urban development, with innovative architecture, as a result of the production of Liquefied Natural Gas (LNG) in many places in the world. This has generated an unprecedented construction boom in the cities and the surrounding areas.

Despite their rather short urban history, the Gulf States have recently launched several signatures mega-projects, where public investments are developing an urban structure of a global dimension. Affecting the direction of the rapid urbanization is a permanent tension between the creation of a new, modern cultural identity and the promotion of traditional architecture. One aim is to establish new connections with local history and cultural traditions.

To reveal the challenge of the construction of a new architectural identity in the Arab emerging cities, this paper focuses on the action needed to preserve historical, cultural, traditional, and architectural heritage, with the aim of filling the gaps of knowledge and encouraging new research in the fields of restoration and conservation that will lead to future practical implementation.

The paper also calls for a fresh look at the tradition, modernity, and identity, by outlining a number of aspects related to the current status of architectural heritage conservation in some Arab cities. Traditional culture, ancient architectural constructions, and vernacular architecture are the result of historical processes and products of Arab societies. Understanding this is an indispensable tool for the comprehension of the Arab modern cities, a knowledge which can influence their future expansion and revitalization, and the shaping of a new architectural identity in these areas. In the Arab regions, restoration methodologies also need to be defined and implemented with the aim of preserving cultural heritage and raising the conservation and restoration research profile among the international research community.
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in combination with standard of care chemotherapy in primarily untreated chemo naïve upper gi-adenocarcinomas with peritoneal seeding – a phase II/III trial of the AIO/CAOGI/ACO
Authors: Oliver Goetze Thorsten , Al-Batran Salah-Eddin , Pabst Urs , Reymond Marc , Tempfer Clemens , Bechstein Wolf O. , Bankstahl Ulli , Gockel Ines , Königsrainer Alfred , Kraus Thomas , Mönig Stefan P. , Rau Beate , Schwarzbach Matthias , Piso Pompiliu
Published: June 2018

Background

Peritoneal metastasis is a common and dismal evolution of several gastrointestinal (GI) tumors, including gastric, colorectal, hepatobiliary, pancreatic, and other cancers. The therapy of peritoneal metastasis is largely palliative; with the aim of prolonging life and preserving its quality. In the meantime, a significant pharmacological advantage of intraperitoneal chemotherapy was documented in the preclinical model, and numerous clinical studies have delivered promising clinical results.

Methods

This is a prospective, open, randomized multicenter phase III clinical study with two arms that aims to evaluate the effects of pressurized intraperitoneal aerosol chemotherapy (PIPAC) combined with systemic chemotherapy vs. intravenous systemic chemotherapy alone on patients with metastatic upper GI tumors with a peritoneal seeding. Upper GI-adenocarcinomas originated from biliary tract, pancreas and stomach, or esophago- gastric junction are eligible. Patients in the study are treated with standard of care systemic palliative chemotherapy (mFOLFOX6) vs. PIPAC with intravenous (i.v.) chemotherapy (mFOLFOX6). Patients in first line with first diagnosed peritoneal seeding are eligible. Primary outcome is progression free survival (PFS).

Conclusions

PIPAC-procedure is explicit a palliative method but it delivers cytotoxic therapy like in hyperthermic intraperitoneal chemotherapy (HIPEC)-procedure directly to the tumor in a minimally invasive technique, without the need for consideration of the peritoneal-plasma barrier. The technique of PIPAC is minimally invasive and very gentle and the complete procedure takes only round about 45 min and, therefore, optimal in a clearly palliative situation where cure is not the goal. It is also ideal for using this approach in a first line situation, where deepest response should be achieved. The symbiosis of systemic therapy and potentially effective surgery has to be well-planned without deterioration of the patient due to aggressive way of surgery like in cytoreductive surgery (CRS)+HIPEC.

Trial registration

EudraCT: 2018-001035-40.
Polish listeners’ perception of vowel inherent spectral change in L2 English
Authors: Schwartz Geoffrey , Dzierla Jerzy
Published: June 2018

This paper describes a perception experiment with Polish listeners involving vowel inherent spectral change (VISC) in L2 English. A forced-choice rhyming task employing the Silent Center (SC) paradigm revealed relatively uniform effects of stimulus type (SC, Initial, Middle, Final) on accuracy across two proficiency groups, despite greater overall accuracy on the part of the more proficient users. Analysis of individual vowel pairs used in the rhyming trials revealed some effects of proficiency on the degree to which formant movement in the stimuli affected identification accuracy. This research contributes to the relatively sparse literature on VISC in L2 acquisition. Phonological considerations underlying the degree of VISC in Polish and English are also discussed.
Opera surtitling in Poland: an uncharted area of AVT?
Authors: Maria Rędzioch-Korkuz Anna
Published: June 2018

Audiovisual translation has become a common subject of a number of scientific articles, special issues of translation journals or conferences. It may seem that this fascinating area of research has been examined thoroughly and may only be investigated further from the point of view of technological improvements in human communication. However, there are certain modalities of AVT which may appear to have been neglected from the scientific point of view. This article is aimed at discussing such a modality of AVT, namely opera surtitling. It concentrates on surtitling strategies employed by Polish opera houses, which are discussed mainly from the point of view of the semiotics of opera and AVT theory. Results of a questionnaire survey on surtitling conducted among operatic audiences are provided to support the discussion. The surtitling strategies as well as particular techniques observed in provided samples are confronted with the accepted practice, which arises from the theoretical prerequisites and seems common to most famous opera houses. It all helps to arrive at the conclusion that this particular AVT modality is a demanding task, requiring both translational and extra-linguistic expertise.
Religionspädagogische Resonanzen in Ost und West: 1968 in transnationaler Perspektive
Authors: Käbisch David
Published: June 2018

Die Proteste des Jahres 1968 sind Teil einer längeren Phase politischer Experimente und sozialer Unruhen in der Tschechoslowakei, in Polen und der DDR als auch in Frankreich, den USA und der Bundesrepublik Deutschland. Wie haben diese Entwicklungen das problemorientierte Lernen im Religionsunterricht verändert? Mit den Methoden der transnationalen Religions- und Bildungsforschung sollen in diesem Artikel erste Antworten auf diese Frage erkundet werden. Im Zentrum stehen nicht die offiziellen Beziehungen zwischen den genannten Staaten, sondern die vielfältigen Akteure und Netzwerke, die für einen grenzüberschreitenden Transfer religionspädagogischer Ideen gesorgt haben.
Determination of Pavement Performance Thresholds for Comfortable Riding on Urban Roads
Authors: Kırbaş Ufuk , Karaşahin Mustafa
Published: June 2018

Whole body vibration (WBV) exposure inside vehicles during transportation affects the driver and passengers adversely, particularly in terms of comfort, health, safety, etc. The main causes of the WBV to which the driver and passengers are exposed are the mechanical structure of the vehicle and road pavements. This study aimed to investigate the relationships between the current performance of pavements and ride comfort for standard passenger cars on urban hot mix asphalt–paved roads, and to specify the threshold values for the pavement condition index (PCI) according to comfort criteria recognized by current standards. For this purpose, PCI values were identified according to the PAVER system on road sections with various performance levels. Vibration data in a vertical direction were measured as defined by ISO 2631-1, Mechanical Vibration and Shock – Evaluation of Human Exposure to Whole-Body Vibration – Part 1: General Requirements, inside the vehicle on the driver seat at ride (driving) speeds of 20, 30, 40, and 50 km/h on the same road section. Assessing these measurements according to the method described in the same standard, awz values were calculated. Subsequently, the relationships between PCI and awz for each ride speed were mathematically modeled by employing artificial neural network (ANN) and fuzzy logic methods. With the aid of these mathematical models, comfort thresholds were determined for each ride speed within an interval of 0 to 100 PCI. The ANN approach was found to be more successful than the fuzzy logic in evaluating the data. The results were evaluated comparatively.
Residual Stress Field of a Single Edge Notch Specimen after Laser Shock Peening and Shot Peening Treatment
Authors: Coratella Stefano , Spradlin T. J. , Langer Kristina , Gharghouri Michael A. , Heckenberger U. C. , Hombergsmeier E.
Published: June 2018

Laser shock peening (LSP) is a reliable, repeatable, and successful surface technique for introducing high magnitude, deep compressive residual stresses that can significantly increase the fatigue life of metallic components. However, depending upon how the LSP treatment is applied, the induced residual stresses can result in the undesirable deformation of the part. In this work, traditional shot peening has been applied over LSP as a means to optimize the stress distribution at the surface of a part while constraining deformation. A single edge notch test specimen of AA7075 was laser peened local to the notch region and then shot peened over the entire central region. The resulting residual stress distribution has been characterized using neutron diffraction to measure the stress distribution in the bulk, and it was compared with (1) incremental center hole drilling to measure the stress distribution up to depths of ∼1 mm and (2) near-surface stresses obtained in a previous X-ray diffraction (XRD) study on nominally identical specimens subjected to the same surface treatments. For regions where the two techniques overlap, the residual stresses are in good agreement (within uncertainty). Comparing the bulk stresses obtained from neutron diffraction in this study and XRD data published elsewhere, it can be shown that shot peening applied after LSP has a profound effect on near-surface stresses; however, these effects disappear at depths of ∼0.7 mm or more.
A Dual sgRNA Approach for Functional Genomics inArabidopsis thaliana
Authors: Pauwels Laurens , De Clercq Rebecca , Goossens Jonas , Iñigo Sabrina , Williams Clara , Ron Mily , Britt Anne , Goossens Alain
Published: June 2018

Reverse genetics uses loss-of-function alleles to interrogate gene function. The advent of CRISPR/Cas9-based gene editing now allows the generation of knock-out alleles for any gene and entire gene families. Even in the model plant Arabidopsis thaliana, gene editing is welcomed as T-DNA insertion lines do not always generate null alleles. Here, we show efficient generation of heritable mutations in Arabidopsis using CRISPR/Cas9 with a workload similar to generating overexpression lines. We obtain for several different genes Cas9 null-segregants with bi-allelic mutations in the T2 generation. While somatic mutations were predominantly generated by the canonical non-homologous end joining (cNHEJ) pathway, we observed inherited mutations that were the result of synthesis-dependent microhomology-mediated end joining (SD-MMEJ), a repair pathway linked to polymerase θ (PolQ). We also demonstrate that our workflow is compatible with a dual sgRNA approach in which a gene is targeted by two sgRNAs simultaneously. This paired nuclease method results in more reliable loss-of-function alleles that lack a large essential part of the gene. The ease of the CRISPR/Cas9 workflow should help in the eventual generation of true null alleles of every gene in the Arabidopsis genome, which will advance both basic and applied plant research.
A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein
Authors: Bryan Anthony C , Zhang Jin , Guo Jianjun , Ranjan Priya , Singan Vasanth , Barry Kerrie , Schmutz Jeremy , Weighill Deborah , Jacobson Daniel , Jawdy Sara , Tuskan Gerald A , Chen Jin-Gui , Muchero Wellington
Published: June 2018

Polyglutamine (polyQ) stretches have been reported to occur in proteins across many organisms including animals, fungi and plants. Expansion of these repeats has attracted much attention due their associations with numerous human diseases including Huntington’s and other neurological maladies. This suggests that the relative length of polyQ stretches is an important modulator of their function. Here, we report the identification of a Populus C-terminus binding protein (CtBP) ANGUSTIFOLIA (PtAN1) which contains a polyQ stretch whose functional relevance had not been established. Analysis of 917 resequenced Populus trichocarpa genotypes revealed three allelic variants at this locus encoding 11-, 13- and 15-glutamine residues. Transient expression assays using Populus leaf mesophyll protoplasts revealed that the 11Q variant exhibited strong nuclear localization whereas the 15Q variant was only found in the cytosol, with the 13Q variant exhibiting localization in both subcellular compartments. We assessed functional implications by evaluating expression changes of putative PtAN1 targets in response to overexpression of the three allelic variants and observed allele-specific differences in expression levels of putative targets. Our results provide evidence that variation in polyQ length modulates PtAN1 function by altering subcellular localization.
Uneven Distribution of Mutational Variance Across the Transcriptome of Drosophila serrata Revealed by High-Dimensional Analysis of Gene Expression
Authors: Hine Emma , Runcie Daniel E , McGuigan Katrina , Blows Mark W
Published: June 2018

There are essentially an infinite number of traits that could be measured on any organism, and almost all individual traits display genetic variation, yet substantial genetic variance in a large number of independent traits is not plausible under basic models of selection and mutation. One mechanism that may be invoked to explain the observed levels of genetic variance in individual traits is that pleiotropy results in fewer dimensions of phenotypic space with substantial genetic variance. Multivariate genetic analyses of small sets of functionally related traits have shown that standing genetic variance is often concentrated in relatively few dimensions. It is unknown if a similar concentration of genetic variance occurs at a phenome-wide scale when many traits of disparate function are considered, or if the genetic variance generated by new mutations is also unevenly distributed across phenotypic space. Here, we used a Bayesian sparse factor model to characterize the distribution of mutational variance of 3385 gene expression traits of Drosophila serrata after 27 generations of mutation accumulation, and found that 46% of the estimated mutational variance was concentrated in just 21 dimensions with significant mutational heritability. We show that the extent of concentration of mutational variance into such a small subspace has the potential to substantially bias the response to selection of these traits.
Maintenance of Proper Germline Stem Cell Number Requires Adipocyte Collagen in Adult Drosophila Females
Authors: Weaver Lesley N , Drummond-Barbosa Daniela
Published: June 2018

Stem cells reside in specialized niches and are regulated by a variety of physiological inputs. Adipocytes influence whole-body physiology and stem cell lineages; however, the molecular mechanisms linking adipocytes to stem cells are poorly understood. Here, we report that collagen IV produced in adipocytes is transported to the ovary to maintain proper germline stem cell (GSC) number in adult Drosophila females. Adipocyte-derived collagen IV acts through β-integrin signaling to maintain normal levels of E-cadherin at the niche, thereby ensuring proper adhesion to GSCs. These findings demonstrate that extracellular matrix components produced in adipocytes can be transported to and incorporated into an established adult tissue to influence stem cell number.
Improving communication within the interdisciplinary team monitoring young women with onco-gynecological pathology in Romania
Authors: Lancrajan Ioan , Lisencu Ioan , Ignat Laurentiu , Trisca Rares , Coman Madalina , Mocean Floarea
Published: June 2018

Background. The quality of medical care, as well as the application of effective treatments in the management of patients with gynecologic neoplasm, is of great importance. Finding new and efficient ways of communication between the doctors involved in the multidisciplinary team for the management of the disease, from the diagnosis to the reintegration into society, would help improve the quality of comprehensive patient care.Objective. The objective of the study was to assess the collaboration of family physicians with specialists treating patients suffering from gynecologic cancer, in order to improve the relationship between them via electronic communication.Study design. We conducted a descriptive, transversal study on 353 family physicians and 37 specialist doctors from Romania, between January and June 2015. For statistical data analysis, R for Data Analysis and Graphics version 3.2.1 was used.Results. Most of the family physicians and specialist doctors believed that they provided the best care that they could, but consider that a multidisciplinary approach using online communication methods, in which doctors collaborate among each other, is needed. Conclusions. Finding a simple, efficient and modern means of communication is essential in order to increase the efficiency of medical care overall.
THE ROLE OF THROMBIN IN CENTRAL NERVOUS SYSTEM ACTIVITY AND STROKE
Authors: Pleșeru Ancuța-Maria , Mihailă Romeo Gabriel
Published: June 2018

Background. Thrombin is a key factor of hemostasis, mediating the conversion of fibrinogen into fibrin. Along with prothrombin, of which thrombin is the active derivative, it has been found locally expressed in the central nervous system. This article aims to describe the role of thrombin in the normal functioning of the central nervous system and stroke.Methods. In this mini-review, the specialized databases Medscape, PubMed, and Web of Science, from the years 2003-2018, were used to find relevant documents by using MeSH terms: ”thrombin” and ”stroke”.Results. Prothrombin and thrombin influence neural development, protection and regeneration, thrombin being a relatively strong regulating factor of brain function. However, high levels of thrombin are detrimental to neuronal health, and cause atherosclerotic plaque development and instability - a leading cause of cerebral infarction. In stroke, thrombin promotes direct cellular toxicity, vascular disruption, oxidative stress and inflammatory response. There is a direct correlation between thrombin activity in the affected brain hemisphere and the infarction volume. Direct acting thrombin inhibitors, like dabigatran, significantly decrease the risk of ischemic stroke.Conclusion. Further studies on the correlation between thrombin levels, generation and activity and the risk and recurrence of ischemic cerebral stroke should give new insight on this association, resulting in an optimized practical therapeutic approach.
A szóolvasás modelljei siketek vizsgálatából származó nemzetközi adatok tükrében
Authors: Varga Vera , Csépe Valéria
Published: June 2018

A siketek olvasási folyamatainak vizsgálatából származó eredmények számos információval szolgálnak a tipikusan működő olvasási rendszer természetéről. A siketség következtében a fonológiai feldolgozás akadályozott, így tesztelhetővé válik a fonológiai rendszer szerepe az olvasásban. Jelen tanulmányban áttekintjük a siketekkel végzett olvasási vizsgálatokból származó főbb eredményeket, ebben külön kitérve a fonológiai, ortográfiai és szemantikai rendszer sajátosságaira, valamint ezeknek a rendszereknek az interakcióira. Végül bemutatjuk, hogy az ismert kutatási eredmények milyen elméleti implikációval bírnak a tipikus olvasás leírására szolgáló kognitív modellek számára.