bluuebunny/crossref_metadata_2025 huggingface dataset:
Нормативне врегулювання освідування як засобу інформаційного забезпечення кримінального провадження
Authors: Лук’янчиков Є. Д. , Лук’янчиков Б. Є. , Микитенко О. Б.
Published: November 2022

Стаття присвячена аналізу процесу нормативного регулювання освідування як одного із засобів інформаційного забезпечення розслідування та формування судових доказів у кримінальному провадженні. Автори досліджують процес становлення, розвитку та нормативного закріплення цього способу отримання інформації про обставини кримінального правопорушення. Проаналізовано також еволюцію розвитку інституту освідування, звернено увагу на те, що на всіх етапах його нормативного врегулювання норми про освідування містилися в одному розділі або в одній статті з оглядом. Це дозволило розглянути освідування як різновид огляду, специфічним об’єктом якого є тіло живої людини, що обумовлює коло завдань, котрі можна вирішувати лише оглядом. Проте у його зміст включено дії, що дозволяли отримувати інформацію в процесі безпосереднього огляду як тіла живої людини, так й інших об’єктів, а також встановлювати психічний стан особи, у якому вона перебувала під час вчинення злочину або після його вчинення (захворіла на божевілля).Зазначено, що для вирішення завдань освідування слідчий наділений правом залучати спеціаліста відповідної галузі знань, у тому числі й медицини. Наголошено, що на певному етапі розвитку законодавства виокремилося два види освідування: слідче та судово-медичне. Перше проводив слідчий, а друге – судово-медичний експерт або лікар. Про результати освідування слідчий складав протокол, судово-медичний експерт – акт, а лікар видавав довідку. Доведено, що в ст. 241 КПК передбачено один вид освідування – слідче, до участі в якому, у разі необхідності, може бути залучений судово-медичний експерт, лікар або інший спеціаліст.
Форми закінчення розгляду цивільних справ без ухвалення рішення по суті справи: історико-правовий аспект
Authors: Мелех Л. В.
Published: November 2022

У статті зроблено теоретичний аналіз питань, що пов’язані із закріпленням у цивільному процесуальному законодавстві України форм закінчення розгляду цивільних справ без ухвалення рішення по суті справи. Досліджено становлення та розвиток цього інституту в цивільному процесі України, а також визначено причини його виникнення й проаналізовано етапи розвитку. Інститут закінчення розгляду цивільних справ без ухвалення рішення має глибоке історичне коріння. Можливість закінчення процесу без вирішення по суті заявлених матеріально-правових вимог була передбачена ще в римському праві. Також процес розгляду справи починався зверненням позивача зі своєю вимогою до претора. Спеціально встановлена форма звернення зобов’язувала починати її словами закону, на який він посилався на підтвердження своїх вимог. Найменший відступ позивача від форми призводив до втрати права на позов. Також справа припинялася в разі неявки позивача на засідання. Закінченню розгляду справи без ухвалення рішення по суті справи в теорії цивільного процесуального права приділялося не досить багато уваги: окремі наукові роботи, присвячені цим формам закінчення судового розгляду, були опубліковані ще в 60-х роках ХХ століття. З прийняттям нового Цивільного процесуального кодексу України підстави для закриття провадження у справі та підстави для залишення заяви без розгляду зазнали змін. Проте в науці цивільного процесуального права ці зміни не було комплексно досліджено.
DIVERSITY OF BODY WEIGHT AND BODY SIZES SUPER VILLAGE CHICKEN
Authors: Jumardin Jumardin , Nafiu La Ode , Rahman Rahman
Published: November 2022

Super chicken is well known as one of the native chicken types which have high body weight which is compared with any other varieties from kampong chicken. But, information is engaged phenotype's characteristic quantitative chicken village super so circumscribed. Therefore in this research, Wight diversity warms up the body criteria for super evaluating village chickens to utilize 100 village super chickens. Weighing and measurement method is utilized for analyzing phenotypes (wight warms up body criteria) weight and measure all samples. Analyze at 4-time threads, Week-2 util 100 village chicken super, Week-4 util 100 heads, Week-6 util 78 heads, and Week 8 util 61 heads. The result of observational pointing out that wight average warms up is super age native chicken 8 weeks 792.30 ± 79.79 diversity coefficients (KK) 8.93. Meanwhile on a par-aged body criteria 8 wing range weeks 164.90 ± 12.73 KK 7.72, long hinder 141.06 ± 15.15 KK 10.74, long chest 72.16 ± 5.57 KK 7.72, long shank 77.25 ± 14.14 KK 18.30, long tibia 95.54 ± 7.05 KK 7.37, long femur 69.50 ± 5.39 KK 7.76, chest circular 20.64 ± 1, 57 KK 7.63, long claws 51.92 ± 4.29 KK 8.27, shank's diameter 11.01 ± 1.01 KK 9.16. Averagely wight warms up CHICKEN village super that maintained up to 8 uniform relative weeks with wight average warms up 792.30 ± 79.79 grams and diversity coefficient 8.93. While for criteria with diversity which is less than 15% or tending more uniform.
EFFECTIVENESS OF KUPANG SEA FLOUR GIVING AS ADDITIONAL FEED ON THE PRODUCTIVITY OF FREE-RANGE CHICKENS IN INCREASING FARMER INCOME
Authors: Abadi Musram , Fatmawati Fatmawati
Published: November 2022

Local chicken is one of the Indonesia native chickens that potential to be developed.  It could be found in all the provinces from the city to the rural area though have the various weather and climate condition.  Feed as one of the three main factors in animal field affect the improvement of animal production in fulfilling the animal protein needs of human.  One of the alternatives to eliminate feed cost is utilizing local resources as protein sources for animal by using sea remis flour.  This study aimed to understand the effectivity of sea remis flour addition on local chicken productivity.  Research method used was completely randomized design consists of 4 treatments and 5 replications by using 40 laying phase local chickens raised intensively for 32 days in battery cages filled 2 chickens per cage unit. Treatment rations were concentrate substitution toward 0% of sea remis flour (R0), concentrate substitution toward 1.5 % of sea remis flour (R1), concentrate substitution toward 3% of sea remis flour (R2), concentrate substitution toward 4.5% of sea remis flour (R3). Based on result of the study, it could be stated that addition of 3% of sea remis flour in ration affect feed consumption, egg production, feed conversion, and egg weight.
Beef Cattle Waste Management as an Effort to Reduce Environmental Pollution
Authors: Rusman Rusni Fitri Y. , Mirnawati Mirnawati , Aldi M , HM Zaenal
Published: November 2022

Waste management is one solution in utilizing beef feces in a beef cattle business. This study aims to provide an overview of waste management in a beef cattle business in Maros Regency, namely CV Enhal Farm. This research was conducted with a direct visit to the location of the Enhal Farm farm located in Tompobulu Village, Tompobulu District, Maros Regency, South Sulawesi. This research was carried out for a month, starting from April to May 2020. The data collection technique was by making direct observations of activities related to the company's operations in order to obtain information directly. The results of the study show that livestock waste management at CV Enhal Farm is carried out starting from the selection of feed to processing biogas which can produce methane gas.
Acidity Level and Cooking Mark Beef Nugget With Different Types of Flour
Authors: Hafid Harapin , Yulianti Yulianti , Napirah Astriana
Published: November 2022

The study aimed to know physic and organoleptic characteristic of beef nugget using different flour. The variable of this study were physic characteristics and organoleptic characteristics. The treatment of this study used different as a filler, were wheat flour, maizena flour, jack fruit seeds flour, and tapioka flour. The data analysis of the study using fully randomized design and least significantly different (LSD) test as post hoc. The result of the study showed using of different flour were wheat flour, maizena flour, jack fruit seeds flour, and tapioka flour, was not significanly different (p>0,05) for pH, cooking lost, aroma, color, and acceptability beef nugget, but very significantly different (p<0,01) for beef nugget flavor, and significantly different (p<0,05) for tenderness and texture of beef nugget.
Utilization of Coastal Resources as Livestock Areas in Konawe Islands Regency
Authors: Syamsuddin Syamsuddin , Baka La Rianda
Published: November 2022

The development of industrial-based livestock in coastal areas is an alternative in supporting domestic meat sufficiency, especially in the Konawe Islands Regency. Coastal areas have quite diverse potential in the tourism, plantation, food crop agriculture and livestock resources sectors. This study aims to analyze the potential of local feed resources based on by-products of food crops to support the development of coastal areas as livestock areas in the Konawe Islands Regency using an analysis of livestock carrying capacity based on the by-products of food crops with the data used in the form of secondary data in 2022. The results of the study showed that the carrying capacity of livestock based on by-products of food crops, namely adult cattle amounted to 1,317.64 livestock units (LU), young cattle 2,745.59 LU, and calf cattle 5,982.92 LU. The results of this study can be concluded that in order to provide animal feed throughout the year for livestock needs, it is possible to utilize local sources of feed originating from food crops.
Goat Farming System in Kolaka District, Southeast Sulawesi
Authors: Hafid Abdul , Pagala Muhammad Amrullah , Syamsuddin Syamsuddin
Published: November 2022

This study aims to identify the goat farming system in Kolaka Regency by collecting research data from primary and secondary data. The determination of the research location was carried out by purposive sampling, namely choosing the research location intentionally based on the consideration that the research location had the largest population of goats in Kolaka Regency in 2021. The selected subdistricts were Watubangga, Toari, and Tanggetada Districts. Each sub-district is represented by 3 villages and each village consists of 10 farmers as research respondents. The results of research on goat breeding systems in Kolaka Regency are generally carried out intensively (36.7%), semi-intensively (32.2%), and extensively (31.1%). The characteristics of the breeder include the age of the breeder, a person's education level, feeding, as well as housing.
Menguji Kinerja Kemitraan Inti-Plasma dengan Analisis Rentabilitas Usaha Peternakan Ayam Broiler
Authors: Pambela Bangkit Adil , Widayanti Sri , Nurhadi Eko
Published: November 2022

The partnership performance of broiler chickens in the nucleus-plasma partnership pattern can be seen from the aspect of profitability, both at the core company and plasma breeders. A balanced partnership performance will create mutually beneficial and unilateral cooperation. This study aims to test the performance of the partnership by analyzing the core-plasma profitability of broiler chicken farms. This study was conducted from December 2020 to January 2021 in Kasiman District, Bojonegoro Regency, East Java. The population in this study was PT. Charoen Pokphand and all broiler bredeers who have a partnership with PT. X and the determinan of respondents is done by census. Data collected were analyzed descriptive quantitatively. The results of the study show that the profitability of the core company is in very healthy condition while the profitability of the plasma breeders is in a healthy condition so that the performance of the core and plasma partnerships in the broiler chicken farm is unilateral weight and is more profitable for the core company.Keywords: rentability; chicken; core-plasma partnership
Strategi Pengembangan Komoditas Sagu di Kabupaten Konawe
Authors: Yuntafau La Ode Ilmin , Saediman Haji , Dirgantoro Muhammad Arief
Published: November 2022

Sago (Metroxylon sp.) is a tropical wet palm plant, which has a strong adaptation to grow on marginal lands. Sago is one of the potential food commodities as a source of carbohydrates owned by Indonesia. The objectives of this study were:  identify the factors that are the strengths, weaknesses, opportunities and threats of sago commodity development; and determine the strategy for sago commodity development. This research was conducted in the Districts of Bondoala, Besulutu, Sampara and Kapoiala, Konawe Regency. The respondents of this study were the relevant government agencies staf in Konawe Regency and in Southeast Sulawesi Province,  researchers from the Southeast Sulawesi AIAT and Development Agency and lecturers at the UHO Faculty of Agriculture, and collectors and inter-island traders. The analytical method used is SWOT-AHP (Analytical Hierarchy Process) analysis. The results of the study revealed that the strategy for developing sago commodities, which had the highest priority value or the most important ones, were the development of human resources for sago farmers and small and medium industries (IKM); strengthening coordination and synchronization of policies between institutions in the development of sago; policy on the expansion and protection of sago land; optimization of market share; diversification of sago products; increasing the competitiveness of processed sago products through the adoption of production technology; modernization of equipment and processing of sago to strengthen added value; and forming partnerships both market and capital.Keywords: development strategy; SWOT-AHP; sago
PERAN DAN KONTRIBUSI TENAGA KERJA WANITA SEBELUM DAN SELAMA COVID-19 PADA USAHA PENGOLAHAN RAJUNGAN (STUDI KASUS UD. SINAR SARINA AFA DI KELURAHAN WATOLO KECAMATAN MAWASANGKA KABUPATEN BUTON TENGAH)
Authors: Diana Diana , Nurdiana A Nurdiana A , Rosmawati Rosmawati
Published: November 2022

Female workers play critical roles in fisheries processing plant thus their contribution to household income.  However, Covid-19 pandemic may cut these contribution due to the declining of fisheries production that reduce the hours of female workers. The purpose of this study was to determine the role of women workers at UD. Sinar Sarina Afaand their contribution on household income before and during Covid-19.This research was conducted at UD. Sinar Sarina Afa is in Watolo Village, Mawasangka District, CentralButon Regency in February – March 2021. The method used in this research was a case study with all female workers at UD. Sinar Sarina Afa as respondents Data were collected through interviews using questionnaires to obtain primary data of respondents, their roles in mini plant and their income.  The data obtained were analyzed using the Harvard Analytical Framework method and income contribution formula.The results showed that before and during Covid-19, female had similar roles in crab processing activities including the stripping, sorting, packaging and cooling processes. During pandemic, the contribution of women in the household income changed from 48% before the pandemic to 42%.   This study showed that the role of female in household is important in increasing family income. Keywords : female; processing; blue swimming crab; mini plant
ANALISIS PENDAPATAN DAN PROPORSI BAGI HASIL NELAYAN PURSE SEINE BERDASARKAN KAPASITAS KAPAL DI DESA BALIMU KECAMATAN LASALIMU SELATAN KABUPATEN BUTON
Authors: Syarifuddin Ahmad , Nurdiana A Nurdiana A
Published: November 2022

This study aims to determine how much income the fishermen who own the purse seine fishing gear and the profit sharing system get based on the capacity of the ship. This study used a census method with 6 respondents and was carried out in Balimu Village, Lasalimu Selatan District, Buton Regency during the period November 2020. The types of data used were primary data and secondary data. Data were collected using interview techniques, questionnaires, documentation and literature study. The data obtained were analyzed using Revenue analysis (TR = PQ), Cost Analysis (TC = TFC.TVC), Income Analysis (π = TR - TC), and Profit Sharing System Analysis (π = Profit (Rp). The results showed that the highest level was obtained by Mr. Safaria, namely Rp. 500,126,880, while the smallest income was obtained by Mr. Hasanuddin, which was Rp. 128,728,827. The profit sharing system treated by fishermen who owned the purse seine was divided by 50:50, meaning the boat owner. get 50% profit from previous income and 50% for ABK. Keywords: Buton Regency; Purse Seine; Income
PREFERENSI KONSUMEN IKAN CAKALANG DI KELURAHAN SODOHOA KECAMATAN KENDARI BARAT KOTA KENDARI
Authors: Ma'ruf Rikal , Budiyanto Budiyanto , Mansyur Akhmad
Published: November 2022

This study aims to determine consumer preferences forskipjack tuna consumers in Sodohoa Village, West Kendari District, Kendari City in January 2022. The method used is accidentasl sampling. The number of samples is this study was 30 samppes. The variables observed were fish size, price, color, cleanliness, and texture of skipjack tuna. Analysis of the data used is Conjoint Analysis. The results showed that the preferences of consumers namely skipjack tuna which is cheap, brightly colored,  stiff textured, clean, with a size of 1 fish/3 kg. Keywords: Conjoint Analysis; Skipjack Tuna; Consumer Preference
HUBUNGAN ANTARA PENDIDIKAN DENGAN PERSEPSI WISATAWAN PANTAI NIRWANA KELURAHAN SULAA KECAMATAN BETOAMBARI KOTA BAUBAU
Authors: Anggriyani Wa Ode , Sadarun Baru , Mansyur Akhmad
Published: November 2022

This study aims to determine the relationship between education and touris tperceptions. The location for the researchis Nirwana Beach, Sulaa Village, Betoambari District, Baubau City in September-October 2020. The method used is accidental sampling and scoring. Data were collected using questionnaires, observation, and documentation. The data analysis used is descriptive and correlation coefficient analysis. As a result, it was found that the perception of tourists on Nirwana Beach wasrated in a fairly good category and the relationship between education and tourist perceptionson Nirwana Beach was 0.941, indicating a very strong relationship because the value is closeto one.Keywords :Correlation, Education, Perception of Tourist
IMPLEMENTASI MODEL PENILAIAN AUTENTIK PADA MATA PELAJARAN RUMPUN IPS DI SMA NEGERI 1 PASIR PUTIH
Authors: Uzin Iksan , Iru La , Hindaryatiningsih Nanik
Published: November 2022

Penelitian ini bertujuan untuk mengetahui implementasi model penilaian autentik pada mata pelajaran rumpun IPS di SMA Negeri 1 Pasir Putih yang sesuai dengan standar penilaian; Kendala-kendala mengimplementasikan model penilaian autentik pada mata pelajaran rumpun IPS  di SMA Negeri 1 Pasir Putih; Upaya yang dilakukan untuk mengatasi kendala dalam mengimplementasikan model penilaian autentik pada mata pelajaran rumpun IPS di SMA Negeri 1 Pasir Putih. Jenis penelitian kualitatif yang bersifat deskriptif. Subjek dalam penelitian ini semua guru rumpun IPS (ekonomi, geografi, sejarah dan Sosiologi) yang berjumlah 4 orang serta sebagai informan adalah kepala sekolah dan wakil kepala sekolah bagian kurikulum. Metode pengumpulan data  yang  digunakan  yaitu observasi, wawancara, dan dokumentasi. Teknik analisis datanya adalah analisis deskriptif  kualitatif,  yaitu reduksi  data, penyajian data, dan penarikan kesimpulan. Hasil penelitian yang dicapai yaitu Implementasi model penilaian  autentik  pada  mata  pelajaran  rumpun IPS (ekonomi, geografi, sejarah dan sosiologi) di SMA Negeri 1 Pasir Putih  telah  dilaksanakan  pada  tiga  ranah  yaitu  kompetensi sikap (afektif) melalui penilaian observasi, penilaian diri, penilaian antar teman siswa, dan penilaian jurnal; kompetensi  pengetahuan (kognitif) melalui penilaian tes tulis, penilaian tes lisan dan penilaian penugasan; dan kompetensi keterampilan (psikomotorik) melalui penilaian praktek, penilaian produk dan penilaian portofolio. Faktor penghambat implementasi model penilaian autentik meliputi banyaknya karakteristik siswa, kompetensi guru dan keterbatasan waktu. Upaya yang  dapat  dilakukan  untuk mengatasi hambatan implementasi model penilaian autentik adalah  mendalami karakteristik siswa, melaksanakan workshop guru dan pengaturan waktu kegiatan penilaian.Kata Kunci: Model penilaian autentik; rumpun IPS
ANALISIS PERAN GURU PENDIDIKAN KEWARGANEGARAAN DALAM PENANAMAN NILAI KARAKTER PADA MATERI PENGARUH KEMAJUAN IPTEK TERHADAP NEGARA KESATUAN REPUBLIK INDONESIA DI SMA NEGERI 1 WAWONII
Authors: Sanur Muhammad , Barlian Barlian , T Samiruddin
Published: November 2022

Penelitian ini bertujuan untuk mendeksripsikan dan menganalisis (1) peran Guru Pendidikan Kewarganegaraan (Pkn) di SMAN 1 Wawonii dalam menananmkan nilai karakter yang terkandung dalam materi Pengaruh Kemajuan Iptek terhadap Negara Kesatuan Republik Indonesia dan (2) nilai karakter yang dapat diimplementasikan dalam materi Pengaruh Kemajuan Iptek terhadap Negara Kesatuan Republik Indonesia. Jenis Penelitian ini adalah penelitian kualitatif deskriptif.Penelitian dengan metode deskripsi Penelitian telah dilakukan pada  di SMAN 1 Wawonii Kabupaten Konawe Kepulauan Provinsi Sulawesi Tenggara. Penelitian ini akan dilaksanakan selama dua bulan, yang dimulai dari bulan Oktober-November 2021.  Hasil penelitian sebagai berikut: 1) Peran Guru PKn di SMAN 1 Wawonii dalam menanamkan nilai karakter dalam materi Pengaruh Kemajuan Iptek terhadap Negara Kesatuan Republik Indonesia. yaitu a)peran dalam bentuk keteladanan, b)peran sebagai inspirator, c)peran sebagai motivator, d)peran sebagai dinamisator dan e)peran sebagai evaluator., dan 2)Nilai karakter yang dapat diterapakan dapat pada saat mengikuti pembahasan materi di Mata Pelajaran Pendidikan Kewarganegaraan (PKn) SMAN 1 Wawonii (Pengaruh Kemajuan Iptek terhadap Negara Kesatuan Republik Indonesia yaitu religius, kejujuran, sikap kerja keras, semangat kebangsaan, kreatif, rasa ingin tahu, tanggung jawab dan gemar membaca.Kata Kunci: Peran Guru; Pendidikan Kewarganegaraan; Pendidikan Karakter
Development of Sugar Products From Aren (Arenga Pinnata Merr) on Customer Satisfaction Using The Method with Kano (Case Study of Home Industry in Kabangka Village Kabangka District Muna Regency
Authors: Karim Zainul , Sadimantara Muhammad Syukri , Sakir Sakir
Published: November 2022

This study aims to determine the attributes that need to be improved, maintained, and repaired to suit the needs of consumers and to determine the level of satisfaction and dissatisfaction of the Nur Mizan household industry and sugar consumers in Kabangka Village, Kabangka District, Muna Regency. The data was collected by using a literature study method, questionnaire, interview, observation, and documentation. The results of the analysis of the Kano method showed that the Must-be category, namely attributes that need to be improved, including the product brand and the design of the ant sugar packaging, including a picture of sugar palm. One-Dimensional category, namely the attributes maintained that the texture of the ant sugar is not hard, the taste of the ant sugar is quite sweet, the sugar dissolves easily when brewed with water, the distinctive aroma of ant sugar is very strong, the ant sugar is yellowish-brown, a slightly bitter taste appears in the sugar, packaging for ant sugar includes information on the composition of raw materials, packaging for ant sugar includes information on net weight, packaging for ant sugar includes information on the benefits of the product and sugar for ants has a lower price than other products. Attractive category, an attribute that needs to be improved is promotional media using Instagram, Facebook, WhatsApp, Line, and Youtube. Furthermore, the level of satisfaction (better) and dissatisfaction (worse) is measured using the Kano diagram with an average better coefficient value of 0.71 and an average score of the worse coefficient of -0.4, a better average value of 0.38 - 0.88. The average score for the worse was between -0.27 - 0.64.
The Effect of Various Doses of Rice Straw Mulch on the Growth and Production of Beans (Phaseolus Vulgaris L.)
Authors: Anti Wa Ode , Rahim Abdul , Erni Wa Ode
Published: November 2022

The purpose of this research was to determine the effect of rice straw mulch and to determine the amount of rice straw mulch that had the best impact on the growth and production of green beans (Phaseolus vulgaris L.). The research was conducted in Lamorende Village, Tongkuno District, Muna Regency, from February to April 2020. Compilation based on a Randomized Block Design (RBD) with one factor consisting of 4 (four) treatment levels, namely M0 = control (without rice straw mulch), M1 = the amount of rice straw mulch 5 tons ha-1 equivalent for 1.2 kg plots - 1, M2 = size of rice straw mulch 10 tons ha-1 is equivalent to 2.4 kg plot-1 and M3 = size of rice straw mulch 15 tons ha-1 is equivalent to 3.6 kg plot-1. From these treatments, they were divided into three groups to obtain 12 experimental units. Observation data from each parameter were analyzed using Analysis of Variance (ANOVA). As for the hypothesis using the F test at the 95% confidence level. The results showed that the treatment of straw mulch dose significantly affected the plants, the number of leaves, the number of pods per plant, pod weight per plant, and the productivity of green beans. Rice straw mulch treatment at a rate of 15 tonnes ha-1, gave the best growth and production.
Effectiveness of Cashew Product Marketing Strategy at UD Cashew Mubaraq Lombe, Lahundape Village, West Kendari District, Kendari City
Authors: Rismayanti Desty , Abdullah Sukmawati , Sakir Sakir
Published: November 2022

UD Cashew Mubaraq Lombe is a trading business that provides a variety of snacks typical of the Southeast Sulawesi region made from cashew nuts. A good marketing strategy is needed to introduce the products at UD Mete Mubaraq Lombe to the public. Marketing strategy is also one of the factors that can direct the level of marketing effectiveness that can be achieved. The effectiveness of the marketing strategy is the extent to which the company achieves the goals that have been agreed upon or previously set. Thus it can be interpreted that if marketing can be carried out correctly as planned or targeted according to the company's goals that have been set, it can be said that the marketing is effective. This study aims to describe the marketing strategy applied by UD Cashew Mubaraq Lombe in increasing the competitive advantage of the products being marketed and to determine the marketing strategy of UD Cashew Mubaraq Lombe's products. The research was carried out in the Lahundape Village, West Kendari District, Kendari City. The study is conducted using qualitative descriptive analysis. The dependent variables are product (X1), price (X2), promotion (X3), place (X4), service (X5), process (X6), people (X7), and physical evidence (X8). The independent variable (Y) is the marketing strategy applied by UD Mete Mubaraq Lombe. The results showed that all the methods used by UD Cashew Mubaraq effectively increased sales volume.
Business Value Added Analysis Copr Processing In UD. Copr Down In Wantulasi Village, Sub-District Of Wakorumba Utara, Buton Utara Regency
Authors: Harisakti Bayu , Hermanto Hermanto , Sakir Sakir
Published: November 2022

This study aims to determine the copra production process in Wantulasi Village, North Wakorumba District, North Buton Regency, and calculate the added value of copra in Wantulasi Village, North Wakorumba District, North Buton Regency. Determination of the research location purposively. Data was collected using observation, interviews, recording, and questionnaires. The analysis used is value-added analysis. Based on the results of research conducted on the value-added analysis of copra processing in Wantulasi Village, North Wakorumba District, North Buton Regency, it can be that the income received at UD. Copra Turuni is Rp.26,250,000. while for added value after processing, the added value is Rp. 3,947/kg per three months in one production and 1 kg of copra is comparable to 3 coconuts with a value ratio of 77%. The income earned by copra farmers from processing coconuts into copra increased, with the copra price being Rp.7500.
Impacts of stress-induced inflammation on feed intake of beef cattle
Authors: Gouvêa Vinícius N. , Cooke Reinaldo F. , Marques Rodrigo S.
Published: November 2022

Livestock animals are often exposed to unavoidable stressful situations during their productive life that triggers stress-induced inflammatory responses, which are known to influence their nutrient requirements and feed intake. Decreased growth performance and immunocompetence of stressed livestock are often the main consequence of reduced feed intake. Because feed intake is usually reduced in animals experiencing stress conditions, concentrations of certain nutrients in the diets typically need to be increased to meet the requirements of the animals. Therefore, understanding the mechanisms that control feed intake in animals experiencing stress-induced inflammation is essential for increasing intake, milk or meat production, feed efficiency, and animal health. This review highlights the hormones regulating feed intake in ruminants and how stress-induced inflammation affect these hormones at local and systemic levels. The mechanism of feed intake regulation in ruminants is extremely complex and involves multiple controls. The liver is an important sensor of energy status in animals under homeostatic conditions, which transmits signals to brain feeding centers that modulate appetite. However, the physiologic consequences associated with different stressors will rearrange the hierarchy of mechanisms controlling feed intake compared to animals under homeostatic conditions, and other tissues (e.g., intestines), systems (e.g., endocrine and lymphatic) hormones (e.g., leptin and ghrelin) will directly affect intake regulation during stress and inflammatory conditions. It is suggested that the immune system can interact with the central nervous system to modulate feed intake. As example, stress events elicit numerous stressors that increase circulating proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-8, and acute-phase proteins (APP), and the magnitude of these responses are negatively correlated with feed intake. A direct effect of these cytokines on rumen microbial fermentation and intestinal barrier function was also reported and might indirectly affect intake regulation in ruminants. This review describes the main hormones and proinflammatory cytokines involved in stress-induced inflammation and how they can directly or indirectly affect intake regulation in ruminants. Understanding the mechanisms controlling feed intake in ruminants will help producers to implement management and feed strategies to optimize productivity and profitability in stressed livestock species.
Washed microbiota transplantation improves patients with metabolic syndrome in South China
Authors: Wu Lei , Lu Xin-Jian , Lin De-Jiang , Chen Wen-Jia , Xue Xing-Ying , Liu Tao , Xu Jia-Ting , Xie Ya-Ting , Li Man-Qing , Lin Wen-Ying , Zhang Qing , Wu Qing-Ping , He Xing-Xiang
Published: November 2022

Background

Metabolic syndrome (MS) is a growing public health problem worldwide. The clinical impact of fecal microbiota transplantation (FMT) from healthy donors in MS patients is unclear, especially in southern Chinese populations. This study aimed to investigate the effect of washed microbiota transplantation (WMT) in MS patients in southern China.

Methods

The clinical data of patients with different indications receiving 1-3 courses of WMT were retrospectively collected. The changes of BMI, blood glucose, blood lipids, blood pressure and other indicators before and after WMT were compared, such as fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c)), high-density lipoprotein cholesterol (HDL-c), non-high-density lipoprotein (non-HDL-c), systolic blood pressure (SBP), diastolic blood pressure (DBP), etc. At the same time, comprehensive efficacy evaluation and atherosclerotic cardiovascular disease (ASCVD) grade assessment were performed on MS patients. Finally, 16S rRNA gene amplicon sequencing was performed on fecal samples of MS patients before and after transplantation.

Results

A total of 237 patients were included, including 42 in the MS group and 195 in the non-MS group. For MS patients, WMT significantly improved the comprehensive efficacy of MS in short term 40.48% (p<0.001), medium term 36.00% (p=0.003), and long term 46.15% (p=0.020). Short-term significantly reduced FBG (p=0.023), TG (p=0.030), SBP (p=0.026) and BMI (p=0.031), and increased HDL-c (p=0.036). The medium term had a significant reduction in FBG (p=0.048), TC (p=0.022), LDL-c (p=0.043), non-HDL-c (p=0.024) and BMI (p=0.048). WMT had a significant short term (p=0.029) and medium term (p=0.011) ASCVD downgrading effect in the high-risk group of MS patients. WMT improved gut microbiota in MS patients.

Conclusion

WMT had a significant improvement effect on MS patients and a significant downgrade effect on ASCVD risk in the high-risk group of patients with MS. WMT could restore gut microbiota homeostasis in MS patients. Therefore, the regulation of gut microbiota by WMT may provide a new clinical approach for the treatment of MS.
Activation of IL1 signaling molecules by Kaposi’s sarcoma-associated herpesvirus
Authors: Chen Jungang , Song Jiao , James Jennifer , Plaisance-Bonstaff Karlie , Post Steven R. , Qin Zhiqiang , Dai Lu
Published: November 2022

Objective

Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi’s sarcoma (KS) and Primary effusion lymphoma (PEL), which are usually seen in immunocompromised patients while lack of effective therapeutic options. Interleukin1 (IL1) family is a major mediator for inflammation response and has functional role in both innate and adaptive immunity. In contrast to the well-studied IL1 molecules, the activation and functional role of IL1 receptor/co-receptor and other related ligands, such as the IL1 receptor accessory protein (IL1RAP), in KSHV pathogenesis and tumorigenesis remain almost unknown.

Methods

In the current study, a series of KSHV negative and positive primary or tumor cells, as well as AIDS-KS tumor samples from cohort HIV+ patients were used to compare and determine the activation status of IL1 signaling molecules, and their functional roles in KSHV pathogenesis.

Results

We reported the high activation of multiple IL1 signaling molecules, including IL1, IL36, IL1R1, IL1RAP and IRAKs, during KSHV latent and lytic stages, as well as in clinical samples from patients with KSHV-related malignancies. Directly targeting these molecules especially IL1R1 and IL1RAP significantly impaired the survival and growth of KSHV+ tumor cells, as well as their colony formation on 3-D culture.

Conclusion

Our data indicate the importance of IL1 signaling molecules in KSHV pathogenesis and tumorigenesis, which may represent attractive therapeutic targets against these virus-associated diseases.
The impact of socioeconomic deprivation on the risk of atrial fibrillation in patients with diabetes mellitus: A nationwide population-based study
Authors: Han Minju , Lee So-Ryoung , Choi Eue-Keun , Park Sang-Hyeon , Lee HuiJin , Chung Jaewook , Choi JungMin , Han Kyung-Do , Oh Seil , Lip Gregory Y. H.
Published: November 2022

Objective

To evaluate the relationship between socioeconomic status and the risk of atrial fibrillation (AF) in patients with diabetes mellitus (DM).

Research design and methods

From the National Health Insurance Service (NHIS) database, we identified 2,429,610 diabetic patients who underwent national health check-ups between 2009 and 2012. Tracing back the subjects for 5 years from the date of health check-up, we determined the subjects’ income and whether they received medical aid (MA) during the past 5 years. Subjects were divided into six groups according to the number of years of receiving (MA groups 0 through 5) and into four groups according to socioeconomic status change during the past 5 years. We estimated the risk of AF for each group using the Cox proportional-hazards model.

Results

During a median follow-up of 7.2 ± 1.7 years, 80,257 were newly identified as AF. The MA groups showed a higher risk of AF than the non-MA group with the hazard ratios (HRs) and 95% confidence interval (CI) 1.32 (1.2–1.44), 1.33 (1.22–1.45), 1.23 (1.13–1.34), 1.28 (1.16–1.4), and 1.50 (1.39–1.63) for MA groups 1 through 5, respectively. Dividing subjects according to socioeconomic condition change, those who experienced worsening socioeconomic status (non-MA to MA) showed higher risk compared to the persistent non-MA group (HR 1.54; 95% CI 1.38–1.73).

Conclusion

Low socioeconomic status was associated with the risk of AF in patients with diabetes. More attention should be directed at alleviating health inequalities, targeting individuals with socioeconomic deprivation to provide timely management for AF.
Diabetes duration and types of diabetes treatment in data-driven clusters of patients with diabetes
Authors: Zhang Jie , Deng Yuanyuan , Wan Yang , Wang Jiao , Xu Jixiong
Published: November 2022

Background

This study aimed to cluster patients with diabetes and explore the association between duration of diabetes and diabetes treatment choices in each cluster.

Methods

A Two-Step cluster analysis was performed on 1332 Chinese patients with diabetes based on six parameters (glutamate decarboxylase antibodies, age at disease onset, body mass index, glycosylated hemoglobin, homeostatic model assessment 2 to estimate β-cell function and insulin resistance). Associations between the duration of diabetes and diabetes treatment choices in each cluster of patients were analyzed using Kaplan-Meier survival curves and logistic regression models.

Results

The following five replicable clusters were identified: severe autoimmune diabetes (SAID), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD). There were significant differences in blood pressure, blood lipids, and diabetes-related complications among the clusters (all P < 0.05). Early in the course of disease (≤5 years), compared with the other subgroups, the SIRD, MOD, and MARD populations were more likely to receive non-insulin hypoglycemic agents for glycemic control. Among the non-insulin hypoglycemic drug options, SIRD had higher rates of receiving metformin, alpha-glucosidase inhibitor (AGI), and glucagon-like peptide-1 drug; the MOD and MARD groups both received metformin, AGI and sodium-glucose cotransporter 2 inhibitor (SGLT-2i) drug ratio was higher. While the SAID and SIDD groups were more inclined to receive insulin therapy than the other subgroups, with SAID being more pronounced. With prolonged disease course (>5 years), only the MOD group was able to accept non-insulin hypoglycemic drugs to control the blood sugar levels, and most of them are still treated with metformin, AGI, and SGLT-2i drugs. While the other four groups required insulin therapy, with SIDD being the most pronounced.

Conclusions

Clustering of patients with diabetes with a data-driven approach yields consistent results. Each diabetes cluster has significantly different disease characteristics and risk of diabetes complications. With the development of the disease course, each cluster receives different hypoglycemic treatments.
Can participation in cooperatives promote the adoption of green production techniques by Chinese apple growers: Counterfactual estimation based on propensity score matching
Authors: Li Dongjian , Dang Hongmin , Yu Jin
Published: November 2022

As one of the key links of agricultural green sustainable development, it is an effective path to popularize green production technology and promote farmers’ adoption of green production technology by using cooperatives as an organizational vehicle. Based on the survey of 314 apple farmers in Shaanxi and Gansu provinces, the degree of adoption of green production technology was measured by the coefficient of variation method. At the same time, in view of the selection bias of farmers’ participation in cooperatives, the propensity score matching method was used to evaluate the influence of farmers’ participation in cooperatives on the adoption of green production techniques. The results showed that participation in cooperatives increases the probability of farmers adopting green production techniques from 25.29% to 30.29%, indicating that cooperatives increase the degree to which farmers adopt green production techniques. In addition, increased cognition of green production, which increases the price and net profit of products sold and reduces expectations of green production risks, is the primary channel through which cooperatives lead farmers to adopt green production technologies. Participation in cooperatives, though, increased input costs for apple production. In order to strengthen the active role of cooperatives in the popularization of green production technologies, more support should be given to cooperatives, and emphasis should be placed on strengthening their institutional development so that they can be standardized and developed at a high quality.
Rationale and design of the Anal HPV, HIV and Aging (AHHA) study: Protocol for a prospective study of anal HPV infection and HSIL among men who have sex (MSM) or trans women living with and without HIV, ages 50 and older
Authors: Hernandez Alexandra L. , Weatherly Christopher Scott , Gonzalez Ryan , Farhat Sepideh , Da Costa Maria , Calderon Joanne , Kauffman Jason , Akha Arezou Sadighi , Hilton Joan F. , Palefsky Joel M.
Published: November 2022

Introduction

More than half of people living with HIV in the US are 50+ years old. Despite the benefits of antiretroviral therapy, older individuals with HIV are at higher risk for illnesses than their HIV-negative counterparts. Anal cancer, anal high-grade squamous intraepithelial lesions (HSIL), and anal HPV-16 infection occur most frequently among men who have sex with men living with HIV (MSMLWH). Men aged 60+ are 3-fold more likely to be diagnosed with anal cancer compared with younger men. Despite the increasing risk of anal cancer with age and HIV, little is known about the relationships among aging, HPV infection, HSIL and HIV.

Methods and analysis

The Anal HPV, HIV, and Aging (AHHA) Study is a two-stage project to evaluate the relationships among anal HPV infection, HSIL, HIV infection, and biomarkers of biological aging in MSM or trans women over the age of 50 years. Stage 1 will estimate the cross-sectional prevalence of both anal HPV infection and HSIL, based on outcomes of anal HPV DNA testing, and high-resolution anoscopy with biopsy. We will also study associations with study outcomes and serological biomarkers of inflammation (interleukin-6, C-reactive protein, D-dimer) and with the Veterans Aging Cohort Study Index and the Fried Frailty Phenotype using multivariable models. Participants living with HIV (n = 150) and HIV-negative participants (n = 150) will be enrolled. The 3-year Stage 2 longitudinal sample restricted to HSIL-negative and anal HPV-16 DNA-negative participants will estimate the 3-year incidence of both anal HSIL and anal HPV, stratified by HIV status through Cox proportional hazards regression. The effect of biomarkers of inflammation and markers of aging on study outcomes will be evaluated through multivariable repeated measures models stratified by HIV status.

Ethics and dissemination

This protocol was approved by the University of California, San Francisco Institutional Review Board (IRB: 16-18966). Results will be disseminated through presentations at national/international scientific conferences and publication in peer-reviewed journals.
Effects of Cerrado restoration on seasonal soil hydrological properties and insights on impacts of deforestation and climate change scenarios
Authors: Pereira Luara Castilho , Balbinot Leonardo , Nnadi Ernest O. , Mosleh Mojan Hadi , Tonello Kelly Cristina
Published: November 2022

Knowing soil indicators during forest restoration is essentially better for understanding the recovery of ecosystem functions for water conservation. The aim of this study is to assess seasonal changes in hydrological properties of sandy soils subjected to passive restoration over 8 (F8), 11 (F11), and 46 (F46) years in the Cerrado. The soils assessed herein have the same land use history and climate conditions. Soil density (SD), moisture (SM), organic matter (SOM), resistance to penetration (SRP), infiltration rate (IR), and soil conductivity (K) were measured for 12 months, and a repellency index (RI) was obtained in the dry season. Some annual soil hydrological property differences based on passive restoration sites were observed, but differences in other properties were only noticed through seasonal analyses. Higher SM, IR, and K values were recorded in the rainy season, and higher SRP values were observed in the dry season. IR was approximately fourfold higher in F8 and threefold higher in F11 and F46 in the rainy season than in the dry season. IR was higher in the oldest restoration site and lower (by over 60%) in the youngest restoration site, which also showed higher RI. Thus, significant differences in several hydrological soil properties and forest restoration soils subjected to the assessed chrono-sequence helped to confirm the study hypothesis, namely: these properties are influenced by forest age and are a warning against deforestation and climate change scenarios. The recovery of hydrological properties can be a slow process, much slower than deforestation, and this can have severe implications because soil water inflow is related to groundwater maintenance. Therefore, improvement of hydrological properties can help to develop sustainable land management and better and more efficient soil conservation strategies for sites undergoing passive restoration such as the Cerrado.
Construction of artificial neural network diagnostic model and analysis of immune infiltration for periodontitis
Authors: Xiang Junwei , Huang Wenkai , He Yaodong , Li Yunshan , Wang Yuanyin , Chen Ran
Published: November 2022

Background: Periodontitis is a chronic inflammatory disease leading to tooth loss in severe cases, and early diagnosis is essential for periodontitis prevention. This study aimed to construct a diagnostic model for periodontitis using a random forest algorithm and an artificial neural network (ANN).

Methods: Gene expression data of two large cohorts of patients with periodontitis, GSE10334 and GSE16134, were downloaded from the Gene Expression Omnibus database. We screened for differentially expressed genes in the GSE10334 cohort, identified key periodontitis biomarkers using a Random Forest algorithm, and constructed a classification artificial neural network model, using receiver operating characteristic curves to evaluate its diagnostic utility. Furthermore, patients with periodontitis were classified using a consensus clustering algorithm. The immune infiltration landscape was assessed using CIBERSOFT and single-sample Gene Set Enrichment Analysis.

Results: A total of 153 differentially expressed genes were identified, of which 42 were downregulated. We utilized 13 key biomarkers to establish a periodontitis diagnostic model. The model had good predictive performance, with an area under the receiver operative characteristic curve (AUC) of 0.945. The independent cohort (GSE16134) was used to further validate the model’s accuracy, showing an area under the receiver operative characteristic curve of 0.900. The proportion of plasma cells was highest in samples from patients with period ontitis, and 13 biomarkers were closely related to immunity. Two molecular subgroups were defined in periodontitis, with one cluster suggesting elevated levels of immune infiltration and immune function.

Conclusion: We successfully identified key biomarkers of periodontitis using machine learning and developed a satisfactory diagnostic model. Our model may provide a valuable reference for the prevention and early detection of periodontitis.