bluuebunny/crossref_metadata_2025 huggingface dataset:
Crohn’s Disease Diagnosed in a Man with Sarcoidosis: Coincidence or Correspondence?
Authors: Mills Krystal , Fatima Shaheen , Fas Norberto
Published: May 2022

Crohn’s disease and sarcoidosis are characterized by noncaseating granulomas, but rarely do they present in the same patient. Their coexistence presents a diagnostic challenge as they are often classified as clinically separate, despite their similarities. We present a case of a 59-year-old man previously diagnosed with pulmonary sarcoidosis who presented to the emergency room with abdominal pain and diarrhea. Colonoscopy revealed multiple ulcers in the colon, with histology in keeping with newly diagnosed Crohn’s colitis. The patient had a good clinical response to initiation of steroid therapy and a tumor necrosis factor (TNF) inhibitor.
Report of a Misleading Case of the Superior Mesenteric Artery Syndrome
Authors: Salehi Amir Mohammad , Salehi Hossain , Hasanzarrini Maryam , Khanlarzadeh Elham
Published: May 2022

Superior mesenteric artery syndrome (SMAS), which is also known as the cast syndrome, Wilkie’s syndrome, or chronic duodenal ileus, is a specific type of duodenal obstruction characterized by the obstruction of the inferior part of the duodenum due to its compression between the superior mesenteric artery (SMA) and the aorta. This problem is usually resulting from loss of the mesenteric fat pad. The present report describes a case of SMAS who was an 18-year-old woman presenting with weight loss and postprandial pain. The patient was initially diagnosed with Helicobacter pylori infection and underwent antibiotic therapy. However, the related symptoms did not resolve. Finally, she was ordered a CT scan, which led to the diagnosis of SMAS.
Prognostic Utility of Platelet-to-Albumin Ratio among Critically Ill Patients with Colorectal Cancer: A Propensity Score Matching Study
Authors: Li Anshu , Wang Zhiyong , Lv Qing , Ling Yan
Published: May 2022

The platelet-to-albumin ratio (PAR) was developed to evaluate inflammatory and nutritional status among patients. The primary goal of the current study was to gain insight into the prognostic role of PAR in critically ill patients with colorectal cancer (CRC). The secondary aim was to develop and verify a clinical model including PAR for the prediction of 28-day mortality. This observational, multicenter study used data from the Medical Information Mart for Intensive Care (MIMIC) IV, e-ICU databases, and Union cohort. Data from 776 critically ill patients with CRC were from the e-ICU database, 219 from the MIMC-IV database, and 135 from the Wuhan Union Hospital. Propensity score matching (PSM) analysis, along with inverse probability treatment weighting, was used to control the influence of confounding factors. Support vector machine (SVM) and LASSO Cox models were then applied to identify significant metrics associated with 28-day mortality in the test cohort. Receiver operating curve (ROC) analysis, along with sensitivity and specificity, was measured to assess the predictive performances of PAR and the survival nomogram. The threshold value for PAR was 8.6, and patients with high PAR (≥8.6) experienced higher 28-day mortality compared to those with low PAR (<8.6). ROC curve analyses revealed that the discriminative ability of PAR was better than platelet count and albumin alone. LASSO Cox regression along with SVM identified six significant metrics associated with 28-day mortality in critically ill patients with CRC, including PAR. The C-index of the critically ill CRC nomogram was 0.802 (0.744–0.859) in the e-ICU training cohort, 0.839 (0.779–0.899) in the e-ICU validation cohort, 0.787 (0.695–0.879) in the MIMIC-IV cohort, and 0.767 (0.703–0.831) in the Union cohort. PAR is a simple score that combines inflammatory and nutritional status. PAR was a reliable index to predict short-term survival outcome of critically ill patients with CRC. Moreover, a clinical nomogram incorporating PAR exhibited satisfactory performance for predicting 28-day mortality of critically ill patients with CRC.
Application of Isomorphic Block Decoration Based on VR and Internet of Things in Fashion Design
Authors: Gan Wen , Lin Li
Published: May 2022

With the development of VR and Internet of things and the characteristics of isomorphic block decoration, based on the two technologies, this paper comes to the realization of isomorphic block decoration in fashion design. Firstly, by analyzing the algorithm combining VR and the Internet of things, a platform based on the combination of both technologies is established. Then, the platform is applied to the same shape block decoration in different cities in the process of fashion design, and the differences in the process of fashion design are analyzed. The results of fashion design show that the isomorphic block decoration based on the combination of VR and Internet of things should be designed according to the local characteristics to promote the development of fashion design industry according to local conditions. In general, this paper provides some theoretical and practical experience for the application of isomorphic block decoration in fashion design.
A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China
Authors: Wang Yawen , Xu Liyan , Wang Shaopei , Yang Kaili , Gu Yuwei , Fan Qi , Wang Qing , Zhu Meng , Guo Kai , Pang Chenjiu , Ren Shengwei , Zhao Dongqing
Published: May 2022

Purpose. The present study investigated the prevalence of keratoconus (KC) among first-degree relatives of KC patients in Central China. Methods. From July 2018 to March 2022, 661 first-degree relatives of 384 KC patients were included in the present study. Corneal tomography, uncorrected distance visual acuity, manifest refraction with corrected distance visual acuity, intraocular pressure, slit-lamp microscopy, and fundus examination were performed. The diagnosis of KC was based on the Belin/Ambrosio enhanced ectasia total deviation value (BAD-D value) on the Pentacam® system (Oculus GmbH). BAD-D value <1.6 was diagnosed as healthy, 1.6≤ BAD-D value <2.6 was diagnosed as suspected KC, and BAD-D value ≥2.6 was diagnosed as KC. Results. The present study included 337 (50.98%) female and 324 (49.02%) male subjects. The prevalence of KC and suspected KC in first-degree relatives was 8.77% (n = 58) and 29.05% (n = 192), respectively. The prevalence of KC was 9.70% among parents and 7.23% among siblings. Conclusions. The higher prevalence of KC among first-degree relatives of patients with KC suggests that first-degree relatives of KC are at high risk of developing KC.
Clinical Analysis of C-Shaped Embedded Pancreaticojejunostomy in Pancreaticoduodenectomy
Authors: Huang Hui , Sun Jichun , Li Zhiqiang , Zang Longjun , Zhu Hongwei , Zhang Xianlin , Yu Xiao
Published: May 2022

Background. Comparing the effects of C-shaped embedded anastomosis and pancreatic duct-jejunal mucosal anastomosis on the incidence of pancreatic fistula after pancreaticoduodenectomy (PD) to find a better pancreaticojejunal anastomosis method that can reduce the occurrence of complications during the operation and benefit the patients. Methods. A retrospective subresearch method was used to select the clinical data of patients who have undergone pancreaticoduodenectomy in our hospital from December 2019 to March 2021. The indicators to be collected for this study include gender, age, body mass index, preoperative liver function (total bilirubin, alanine aminotransferase, and albumin), preoperative comorbidities (diabetes, chronic pancreatitis), and pancreatic condition (texture, pancreatic duct diameter). The patients were divided into two groups according to the method of pancreaticojejunostomy: C-shaped embedded anastomosis group (

n
=
38

) and pancreatic duct-jejunal mucosal anastomosis group (

n
=
30

). The duration of pancreaticojejunostomy, biliary-enteric anastomosis, gastrointestinal anastomosis, intraoperative blood loss, upper abdominal surgery history, pathological type, intraoperative blood loss, pancreaticojejunostomy time, combined pancreatic fistula, biliary fistula, hemorrhage, and abdominal infection were observed and compared. According to the different methods of pancreaticojejunostomy during operation, they were divided into group A: C-shaped embedded pancreaticojejunostomy group (38 cases), and group B: pancreatic duct-jejunal mucosal anastomosis group (30 cases). The postoperative complications were compared between the two groups, and the observed indicators were analyzed with statistical methods. Results. The average pancreaticojejunostomy time in group A was

32.13
±
4.52

 min, and the average pancreaticojejunostomy time in group B was

43.23
+
4.31

 min. The difference was statistically significant (

p
<
0.05

). Neither group A nor group B had a grade C fistula. The incidence of biochemical fistula in group A was 21.05% (8/38), and the incidence of biochemical fistula in group B was 13.3% (4/30). The difference was not statistically significant (

p
>
0.05

). The incidence of grade B fistula in group A was 5.20% (2/38), and the incidence of grade B fistula in group B was 26.67% (8/30). The difference was statistically significant (

p
<
0.0

5). There were no perioperative deaths in the two groups. Conclusion. According to the results of data analysis, it can be seen that both the two types of pancreaticojejunostomy have good clinical effects, but that in terms of reducing the grade of pancreatic fistula, the C-shaped embedded pancreaticojejunostomy is obviously better and safer. At the same time, the C-shaped embedded pancreaticojejunostomy can shorten the time of pancreaticojejunostomy and is easier to operate, thus worthy of clinical promotion.
Evaluation of the Quality of Football Teaching in Colleges and Universities Based on Artificial Neural Networks
Authors: Yang Rui , Lin Hui
Published: May 2022

Every country is developing under the concept of artificial intelligence. Many countries are already working on student monitoring systems that allow them to control the student’s mentality and analyze each student’s behavior with the help of a wireless headband. There is certain high-tech education within the country in a maximum number of schools, which can be considered robotic monetization. With the help of tiny robots inside the classrooms, each student’s activeness and engagement level in the classes are captured and submitted to the teacher. All these practical applications help us imagine that there will be a massive response to artificial intelligence in the future of this world. On the other hand, sports management is a critical issue to consider for the country’s growth. This research evaluates the quality of football teaching by implementing an Artificial Neural Network model for online mode of education. The proposed model functions with the implementation of Association Rule Mining (ARM) in the intelligent system to monitor the activities of the player by training with the Artificial Neural Network (ANN). The proposed model is compared with the existing K-Mean algorithm, and it is observed that the proposed model has achieved an accurate evaluation of 99.6%.
Edge Computing Deployment Algorithm and Sports Training Data Mining Based on Software Defined Network
Authors: Yang Minggang , Gao Cuifang , Han Junmei
Published: May 2022

The wireless sensor network collects data from various areas through specific network nodes and uploads it to the decision-making layer for analysis and processing. Therefore, it has become a perception network of the Internet of Things and has made great achievements in monitoring and prevention at this stage. At this stage, the main problem is the motive power of sensor nodes, so the energy storage and transmission of wireless sensor network is imminent. Mobile edge computing technology provides a new type of technology for today’s edge networks, enabling it to process resource-intensive data blocks and feedback to managers in time. It is a new starting point for cloud computing services, compared to traditional cloud computing services. The transmission speed is more efficient and will be widely used in various industries and serve them in the future. Among them, education and related industries urgently need in-depth information, which in turn promotes the rapid development of data mining by sensor networks. This article focuses on data mining technology, mainly expounds the meaning and main mining methods of data mining technology, and conducts data mining on sports training requirements from the aspects of demand collection and analysis, algorithm design and optimization, demand results and realization, etc. Monitor the training status and give the trainer reasonable suggestions. Through the processing of the training data mining results and proofreading the database standardized training data, we can formulate a personalized program suitable for sportsmen, reduce sports injuries caused by no trainer’s guidance, and open new doors for training modes. Therefore, this paper studies the sensor network technology, edge computing deployment algorithm, and sports training data mining.
Total Saponins of Radix Clematis Regulate Fibroblast-Like Synoviocyte Proliferation in Rheumatoid Arthritis via the LncRNA OIP5-AS1/MiR-410-3p/Wnt7b Signaling Pathway
Authors: Pan Lingyu , Sun Yuan , Jiang Hui , Chen Yan , Jiang Yeke , Han Yanquan , Wang Yongzhong
Published: May 2022

Background. Rheumatoid arthritis (RA) is the most common autoimmune disease and affects multiple joints. Previous studies have shown that total saponins of Radix clematidis (TSC) have a clear therapeutic effect on RA, but the specific mechanism has not yet been clarified. Literature screening and previous research suggest that the lncRNA OIP5-AS1/miR-410-3p/Wnt7b signaling pathway exerts a regulatory effect on the pathogenesis of RA. In this study, we examined whether the TSC treatment of RA affects the lncRNA OIP5-AS1/miR-410-3p/Wnt7b pathway. Materials and Methods. Freund’s complete adjuvant was used to create an adjuvant arthritis (AA) rat model with rat synovial cells being harvested and cultured. The experiment comprises a normal group, model group, TSC optimal-dose group, TSC optimal-dose group + lncRNA OIP5-AS1siRNA group, lncRNA OIP5-AS1 siRNA group, and lncRNA OIP5-AS1 siRNA + NC group. MMT was used to screen the optimal concentration of TSC. The level of lncRNA OIP5-AS1, miR-410-3p, Wnt7b, β-catenin, c-Myc, cyclin D1, GSK-3β, and SFRP4 mRNA were detected by real-time-qPCR, the expression of Wnt7b, β-catenin, c-Myc, cyclin D1, GSK-3β, and p-GSK-3β (Ser9) protein were detected by immunofluorescence and Western blot. Results. We found that TSC inhibits the proliferation of RA FLS, TSC significantly reduced lncRNA OIP5-AS1, Wnt7b, β-catenin, c-Myc, cyclin D1, and p-GSK-3β/GSK-3β mRNA/protein expression, whereas the miR-410-3p and SFRP4 mRNA/protein expression levels were significantly upregulated. Our data suggest that TSC can inhibit the excessive proliferation of FLS to treat RA, the mechanism of which may be closely related to regulation of the lncRNA OIP5-AS1/miR-410-3p /Wnt7b signaling axis and the Wnt signaling pathway.
Correlation Analysis of Interbank Money Market Interest Rate and Financial Crisis Based on Neural Network Model
Authors: Zeng Xiaohua , Yuan Chiping , Liang Changzhou
Published: May 2022

This paper combines the neural network model to analyze the correlation between the interbank money market interest rate and the financial crisis, and theoretically analyzes the influence of the characteristics of the banking industry on the transmission of monetary policy interest rates. Moreover, this paper constructs a theoretical model to analyze the influence of banking industry characteristics on the transmission of monetary policy interest rate and examines whether the variables of banking industry characteristics still affect the measurement indicators of monetary policy interest rate transmission after the financial crisis subsides. In addition, this paper combines the neural network model to construct a correlation analysis system between the interbank money market interest rate and the financial crisis. The experimental research shows that the correlation analysis between the interbank money market interest rate and the financial crisis based on the neural network model proposed in this paper can play a certain role.
Application of Spectroscopy Technology in Nanomaterials in Identification of Chinese Paintings
Authors: Bai Lili , Kou Heung , Kong Zi
Published: May 2022

The authenticity of calligraphy and painting is an important knowledge in the collection and research of Chinese painting and calligraphy. The identification of folk painting and calligraphy is usually conducted by experts and scholars engaged in cultural relics, archaeology, painting and calligraphy, and ancient buildings. Relying only on the identification of experience and literature and history, there are certain limitations, and it is difficult to form convincing. Spectroscopic technology mainly uses the characteristic spectral lines of molecules or atoms to judge the chemical composition and relative content of substances, so that different molecular structures of substances can be determined and distinguished; thus, it becomes an effective tool for exploring the molecular structure of substances; therefore, it has been widely used in nanomaterials, biomedicine, cultural relic identification, and other fields. Raman spectroscopy is the most common spectroscopic technique in scattering spectroscopy. When light passes through a material surface, in addition to light transmission and light absorption, light scattering can also be observed. In addition to the original incident light frequencies (Rayleigh scattering and Tyndall scattering), the scattered light also includes some new frequencies, which are called Raman scattering, and its spectrum is Raman spectrum. In this paper, Raman spectroscopy is used to study nanomaterials and calligraphy and painting, and the Raman spectra of real and fake calligraphy and painting, as well as the light absorption rate and degradation rate of nanomaterials at different temperatures, are analyzed experimentally. The results show that the Raman spectrum of the authentic calligraphy reaches the maximum when the wave number is 1000; the peak of the Raman spectrum of the authentic fresco reaches the maximum when the wave number is 1400. The average light absorption rate of nanomaterials in was 47.2%, and the average catalytic degradation rate was 53.6%; the average light absorption rate of nanomaterials was 68.9%, and the average catalytic degradation rate was 62.4%. There are obvious differences in peak shape, peak intensity, peak frequency, etc. between genuine and fake calligraphy and painting. The spectrum of genuine works has good consistency, so the authenticity of calligraphy and painting can be distinguished according to the difference between the spectrums.
Application Preparation of High‐Performance Iron‐Based Powder Metallurgy Sintered Materials in Sports Industry
Authors: Yang Baifang
Published: May 2022

Nowadays, the rapid development of sports science and technology has brought about the vigorous development of the sports industry, which is worth studying for a long time in the future. This article aims to use metallurgical sintering technology to prepare high‐performance iron‐based powder materials and apply them in the traditional sports industry to produce new sports equipment. This article proposes a metallurgical sintering method, that is, the use of a process of powdered iron‐containing materials through a series of operations to finally obtain a new agglomerate and to obtain the required new physical and mechanical properties of materials or products. A new type of material is made and used in the traditional sports industry to meet the high‐quality needs of sports equipment in the current era. According to survey statistics, my country’s sports industry has been developing rapidly in the past five years. It has increased from 1,901.13 billion yuan in 2016 to 2,869.35 billion yuan in 2020. Sports investment and financing events have also dropped from 313 to 105, but the entire sports industry’s investment is getting bigger and bigger. The number of employees in the national sports industry has also exceeded the 2 million mark. In the future, the sports industry is also an industry with great potential for development.
Scanning Imaging Study of Patients with Parkinson’s Disease Lower Urinary Tract Dysfunction Based on Linear Equation
Authors: Liu Yong , Han Jiasheng , Guo Xuguang , Fang Lei , Liu Ting
Published: May 2022

A predictive method based on a linear equation was proposed to study the factors influencing lower urinary tract dysfunction in Parkinson’s disease. A 10-month follow-up of 200 selected Parkinson’s patients from January to December 2020 used a linear regression equation to analyze whether depletion function was associated with a specific nonmotor function loss, and a linear regression equation was used for analysis. A loss of emptiness function was used to determine whether there are complications associated with lower motor function and cognitive function. The experimental results showed that dysuria in Parkinson’s disease was related to the following nonmotility disorders: gastrointestinal dysfunction (OR 2.52, 95% CI 1.57-3.92,

P
<
0.001

), cardiovascular dysfunction (OR 2.31, 95% CI 1.23~4.11,

P
=
0.014

), respiratory dysfunction (OR 1.72, 95% CI 1.32~3.24,

P
=
0.029

), cutaneous autonomic dysfunction (OR 1.91, 95% CI 1.15~3.08,

P
=
0.023

), and sleep disorders (OR 2.01, 95% CI 1.32~3.14,

P
=
0.001

). In addition, dysuria was associated with higher UPDRS-III (regression coefficient 1.74, 95% CI 0.56-2.67,

P
=
0.001

). Thus, nonmotor disorders have been shown to be associated with early impairment.
Capacity Policy for an OEM under Production Ramp-Up and Demand Diffusion
Authors: Chang Chung-Ho , Chen Jen-Ming
Published: May 2022

This paper presents a study on capacity policy for an OEM, launching a new short life cycle consumer durable product, and undergoes a demand diffusion process and a production ramp-up process with learning. The demand/supply dynamic system is described by the Bass diffusion demand rate and time constant production rate. The mismatch of demand peak and production plateau creates challenges for balancing the interactive trajectories. Indivisible lumpy capacity increments in the production network exacerbate the difficulty. In conjunction with mathematical and graphical analysis and computation power, we model a discrete optimization model (running on CPLEX) to investigate “how the OEM should determine an optimal capacity size” and “when to market the new product and expand capacity” under various Bass parameters, which describe the behavior intensity of the innovation and imitation of new product consumers.
Community Level Youth-Led Interventions to Improve Maternal-Neonatal Outcomes in Low- and Middle-Income Countries: Protocol for a Systematic Review
Authors: MacDonald Tonya , Gentles Avonae , Liu Rachel , Stevens-Uninsky Maya , Anni Naharin Sultana , Rehman Nadia , Darling Elizabeth K. , Greene Saara , Moll Sandra , Mbuagbaw Lawrence
Published: May 2022

Introduction. On a global scale, women and childbearing people and neonates continue to die from preventable causes related to pregnancy or childbirth. Sustained and accelerated efforts are critical to improve maternal and neonatal health and well-being. Globally, youth are a growing population and have strength in their numbers. Youth are critical, key drivers of change in their communities. Young people hold the potential to affect positive change, and their meaningful engagement is important to improving maternal health and well-being in low- and middle-income countries. Objectives. To assess the effects of community level youth-led interventions for improving maternal-neonatal health and well-being compared with no interventions or another intervention. Methods. We will undertake a literature search that is comprehensive, complete, and exhaustive. This will include databases such as MEDLINE, EMBASE, and the Cochrane Library, as well as a grey literature search. In our systematic review, we will include experimental studies evaluating maternal-neonatal health and well-being associated with or because of the implementation of community level youth-led interventions. Participants will include women and childbearing people (of any age) during antepartum, intrapartum, and postpartum periods (up to 42 days postpartum). We will examine all interventions addressing and targeting maternal-neonatal health and well-being that are youth-led and community-based and aimed at the members of the community. Our comparators will be no intervention or another intervention. Our primary outcomes are maternal deaths and neonatal deaths. Our review will include only studies in low- and middle-income countries conducted in urban or rural areas. Ethics and Dissemination. Ethics approval is not required as we will use secondary data that is publicly available. There are no active participants in our study. We will involve key stakeholders and experts in maternal-neonatal health regarding dissemination and knowledge mobilization strategies. Our findings will be disseminated as an open access publication, be presented publicly, and defended as part of a doctoral thesis. This trial is registered with CRD42021288798.
Art Decoration Design of Electrochemical Silicon Oxide Ceramic Sculpture Based on 3D Printing Technology
Authors: Guo Jifeng
Published: May 2022

In order to solve the art decoration design of silicon oxide ceramic sculpture, a method for silicon oxide ceramic sculpture based on 3D printing technology is proposed. Firstly, the density of photosensitive resin premix before curing was measured by pycnometer method; the photosensitive resin was coated on tinplate and then put into a self-made UV curing box for curing. Secondly, the critical exposure and critical transmission depth of photosensitive resin without formula are calculated. Finally, the viscosity of ceramic slurry was measured by mixing S2 photosensitive resin formula with ceramic powder with different nano silica content. It is proved that the addition of nano silica powder can promote the decomposition of quartz glass and increase the sintering degree of the ceramic core. The primary sintering shrinkage of ceramic core gradually increases with the increase of nano silica content. In the length direction, the shrinkage increases from 3.33% to 5.61%; in the width direction, the shrinkage increases from 2.98% to 4.74%; and in the height direction, the shrinkage increases from 3.18% to 5.00%.
Carcinoma basocelular de couro cabeludo x alopecia frontal fibrosante: desafio diagnóstico e terapêutico
Authors: Guilherme Marina Riedi , Santos Bruna Cristina Mendes dos , Imazu Lúcia Emiko , Machado Marcelo de Souza
Published: May 2022

O carcinoma basocelular é considerado a neoplasia mais comum do mundo, tem como principal fator de risco a radiação ultravioleta, pode aparecer em todo o corpo incluindo couro cabeludo. A alopecia frontal fibrosante é uma alopecia cicatricial primária, variante do líquen planopilar. A associação entre as duas patologias não tem relato prévio na literatura. Neste caso apresenta-se paciente feminina, pós-menopausa, atendida por queixa de queda de cabelo, com diagnóstico histopatológico de alopecia frontal fibrosante e carcinoma basocelular de couro cabeludo. A distinção das margens tumorais para exérese completa da neoplasia é complexa apenas pela dermatoscopia e exame físico, devido á presença de áreas de atrofia em comum. Então se optou pela cirurgia micrográfica de Mohs para delimitação histopatológica de margens.
Plantas medicinais e fitoterápicos no cuidado da saúde mental em tempos de pandemia: uma revisão da literatura
Authors: Mendonça Neto Ivan Justo de , Costa Sabrina Santos Lourenço da , Barboza Vinícius de Noronha , Vale Clara Maria Germano Cidrack do , Nunes Francisco Vitor Aires , Aires Caio Augusto Martins , Moraes Maiara de , Brito Teresinha Silva de
Published: May 2022

Apesar do uso de plantas medicinais para tratamento de problemas de saúde ser tradicionalmente aceito, esta prática da medicina popular ainda encontra resistência por profissionais da saúde, sobretudo sob a alegação da falta de comprovação de seus efeitos. Durante o surto de Covid-19, houve aumento significativo do estresse, sintomas ansiosos e insônia e o uso de plantas medicinais e fitoterápicos surge como uma alternativa terapêutica. O objetivo deste estudo foi realizar uma revisão da literatura sobre a eficácia de plantas medicinais como terapia alternativa e/ou complementar para transtornos de ansiedade e insônia. As plantas investigadas foram selecionadas a partir do Formulário de Fitoterápicos e Memento Fitoterápico da Farmacopeia Brasileira, sendo utilizados como descritores o nome científico da planta e os termos “anxiety” e “insomnia” com recorte temporal de 2015 a 2020. 230 resultados foram encontrados, 42 selecionados (27 em humanos e 15 em animais). Foi possível demonstrar efeitos ansiolíticos para as plantas capim santo (Cymbopogon citratus), lavanda (Lavandula officinalis), melissa (Melissa officinalis), maracujá (Passiflora incarnata) e valeriana (Valeriana officinalis) e sedativos para melissa, maracujá e valeriana. A kava-kava (Piper methysticum) demonstrou apenas efeito sedativo e a camomila (Matricaria chamomilla) apresentou eficácia clínica ansiolítica. Portanto, a potencial aplicação clínica dessas plantas é indicada para tratamento dos sintomas de ansiedade e insônia, ajudando a reduzir os sintomas psicológicos decorrentes da pandemia de Covid-19. Contudo, vale ressaltar a necessidade da padronização dos procedimentos metodológicos e avanço da fitoterapia na prática médica.
Diagnóstico, tratamento e impactos dos problemas de saúde mental no pós-infarto: uma revisão sistemática
Authors: Tembra Samantha , Pegorini Henrique José , Reis Lucimar de Lara Aires
Published: May 2022

Depressão e ansiedade são transtornos prevalentes no período pós-infarto do miocárdio e constituem fatores que acrescem incapacidades e influenciam a morbimortalidade do paciente previamente infartado. No entanto, não há diretrizes nacionais no que diz respeito às repercussões na qualidade de vida, às estratégias para diagnóstico e ao melhor tratamento dessas comorbidades. Além disso, as evidências existentes frequentemente não se encontram reunidas em protocolos específicos internacionalmente aceitos, dificultando a reprodutibilidade da conduta mais adequada. Dessa forma, o objetivo desta revisão sistemática é analisar as repercussões dos problemas de saúde mental para o indivíduo previamente infartado, buscando apresentar opções terapêuticas que possam ser ofertadas pela Saúde Primária. Assim, realizou-se pesquisa nas bases de dados PubMed, Lilacs, SciELO e BVS com os Mesh Terms “myocardial infarction”, “mental health” e “primary care” e o boleano “AND”. Foram selecionados 30 artigos em língua portuguesa e inglesa que mais adequadamente se relacionavam com os objetivos deste trabalho, utilizando-se os critérios PRISMA. O recorte temporal analisado compreende os anos de 2011 a 2021. Os resultados da pesquisa mostraram associações entre ansiedade, depressão e outros problemas de saúde mental e diminuição da qualidade de vida, como readmissão hospitalar, maiores custos em saúde, dor torácica, e maior risco de desfechos cardiovasculares. As escalas validadas mostraram-se ferramentas úteis no diagnóstico das comorbidades mentais no pós-infarto. Dentre as opções terapêuticas mais eficazes encontradas, estão as de enfoque psicossocial e a Terapia Cognitivo-Comportamental, havendo grande divergência literária a respeito dos antidepressivos. Dada a grande repercussão na qualidade de vida do indivíduo pós-infartado, mais estudos são necessários para definir melhores abordagens terapêuticas com evidente redução na mortalidade.
Avaliação do perfil bioquímico, hematológico e imunológico em pacientes com diagnóstico recente para HIV de um Centro de Referência em Santarém, Pará, Brasil
Authors: Watanabe Beatriz Toyama , Berretta Olívia Campos Pinheiro , Silva Erek Fonseca da , Assy João Guilherme Pontes Lima , Fernandes Eduardo Vignoto , Gouvêa-e-Silva Luiz Fernando
Published: May 2022

Introdução: Alterações hematológicas, bioquímicas e imunológicas podem estar presentes no paciente infectado pelo HIV, no momento do diagnóstico, antes ou depois de iniciar com os antirretrovirais. Objetivo: Analisar o perfil bioquímico, hematológico e imunológico de pacientes com diagnóstico recente para HIV. Método: O estudo avaliou 321 prontuários de pacientes recém diagnosticados com a infecção pelo HIV. A coleta de dados envolveu informações sociodemográficas (data de nascimento, idade, sexo, escolaridade, estado civil, vínculo empregatício e procedência), clínicas (data do diagnóstico para a infecção pelo HIV, situação de imunodeficiência e tipo de exposição), bioquímicas (glicose, triglicerídeos, colesterol total e frações), hematológicas (hemoglobina e plaqueta) e imunológicas (linfócitos T CD4+ e carga viral). Os dados foram analisados por estatística descritiva e inferencial, adotando-se p<0,05. Resultados: Notou-se predominância do sexo masculino (67%), faixa etária de 18-27 anos (39,9%), solteiros (58,6%) e com 32% dos pacientes apresentando Aids. Das variáveis analisadas, o sexo masculino apresentou, em relação às mulheres, maior quantidade de hemoglobina e menores valores para contagem de linfócitos T CD4+, glicose e colesterol total (p<0,05). Além disso, ressalta-se que 69% da amostra apresentou alguma alteração lipídica, 96% tinha carga viral detectável e 29% apresentou linfócitos T CD4+ <200 cel/mm3. Conclusão: Pessoas vivendo com o HIV, no momento do diagnóstico, podem apresentar alterações imunológicas, hematológicas e bioquímicas, tornando imprescindível a avaliação, acompanhamento e orientação multiprofissional, tanto antes como posterior introdução dos antirretrovirais, a fim de evitar futuros agravos a saúde.
Prevalência da sintomatologia depressiva em estudantes de medicina de uma universidade no nordeste brasileiro
Authors: Melo Beatriz Tavares de , Ferreira Júlia Silva , Melo Soniely Nunes de , Correia Marcos Leonardo Farias , Mourão Ana Raquel Carvalho de , Bomfim Ana Marlusia Alves
Published: May 2022

Introdução: A depressão é uma doença complexa, em que seu surgimento e desenvolvimento são marcados pela influência de diversos fatores. Os estudantes do curso de medicina tendem a compreender um grupo vulnerável à doença, visto que os mesmos lidam diariamente com fatores estressores durante toda a graduação. Objetivo: Estudar a prevalência dos sintomas do transtorno depressivo maior nos discentes de medicina de uma instituição de ensino superior no estado de Alagoas, nordeste do Brasil. Metodologia: Estudo epidemiológico elaborado com a participação de 259 estudantes do curso de medicina de uma instituição de ensino superior do nordeste do país, no período de agosto de 2019 e julho de 2020. O instrumento de coleta dos dados foi um questionário sociodemográfico e o Inventário de Beck (IDB). Resultados: Foi encontrada, no estudo dos sintomas depressivos nessa população, a prevalência de 51,80%. Sobre a realização de tratamento psicológico e psiquiátrico, grande parte respondeu jamais ter procurado ajuda profissional, apesar de 29,3% fazer uso de algum psicofármaco. Conclusão: As informações coletadas poderão ser utilizadas para contribuição dos dados epidemiológicos do país, de modo a propiciar melhorias na formação dos estudantes da graduação, uma vez que o reconhecimento do problema e suas variáveis prevalentes poderão determinar novas abordagens, bem como a conscientização acerca dessa patologia e de seu cuidado adequado.
Cisto branquial da 4ª fenda – relato de caso
Authors: Cascabulho Ana Maria Esteves , Verdan Tatiana Vargas Queiroz , Carmo Rebeca dos Santos Veiga do , Frizzo Ana Paula Machado , Silva Julia Bino Aguiar da , Gottardi Lorena de Freitas , Rossi André Pancrácio , Lima Fernanda Cardilo
Published: May 2022

Introdução: Os cistos branquiais são tumores congênitos laterais, resultantes de defeitos de desenvolvimento embrionário que afetam os arcos branquiais.1 As anomalias congênitas cervicais são mais comumente diagnosticadas nos primeiros anos de vida. Objetivo: Informar, discutir e analisar condutas para tratamento desse tipo de cisto congênito. Método: Relato de caso e análise de dados, diagnósticos e conduta baseada na literatura referente a Cisto Branquial da 4° Fenda. Resultados: Os cistos podem se manifestar tardiamente, mas as fístulas são, quase sempre, diagnosticadas ao nascimento ou na infância. São extremamente raros, estima-se que 95% das anomalias das fendas branquiais sejam da 2ª fenda; das 5% restantes, quase todas são da 1ª ou 3ª fenda. O diagnóstico é primariamente clínico, mas a ultrassonografia pode auxiliar no diagnóstico diferencial de um cisto branquial. O tratamento das anomalias branquiais é a excisão cirúrgica. Lactente sexo feminino, 9 meses de idade em acompanhamento de cisto branquial com conduta conservadora. O surgimento da massa se deu logo ao nascimento, havendo drenagem espontânea do cisto para o esôfago alguns dias depois. Após nove meses paciente retorna devido aumento progressivo da lesão que correlacionando com exame físico, exames de imagem levaram ao diagnóstico de cisto de 4º fenda branquial. Realizada cirurgia para remoção de Cisto juntamente com retirada de lobo esquerdo da tireoide (tireoidectomia parcial). Conclusão: Após a exerese da lesão paciente evoluiu satisfatoriamente sendo encaminhado para enfermaria e posteriormente alta com acompanhamento ambulatorial com pediatra geral.
Avaliação do crescimento estatural e da puberdade de crianças e adolescentes com sobrepeso e obesidade
Authors: Souza Carolina Martins de , Yamamoto Tamara , Kochi Cristiane
Published: May 2022

Introdução: A obesidade infantil, além de fator de risco para outras doenças metabólicas, pode também alterar o crescimento e os padrões de puberdade. Objetivos: No sexo feminino, a obesidade é associada à antecipação da puberdade. No sexo masculino, existem poucos estudos e há divergências. Este estudo, assim, busca avaliar o crescimento e puberdade em crianças e adolescentes acima do peso. Métodos: Estudo retrospectivo, com análise de prontuários médicos de pacientes em idade pré puberal e puberal com sobrepeso ou obesidade. Os dados obtidos foram: peso, estatura (E), índice de massa corporal (IMC), circunferência abdominal (CA), e estadiamento puberal. Resultados: Não houve impacto da gravidade da obesidade na idade cronológica (IC) de entrada na puberdade ou na estatura. A estatura final média das pacientes do sexo feminino permaneceu dentro do alvo familiar, e a estatura final dos pacientes do sexo masculino permaneceu acima do padrão genético. Discussão: As pacientes do sexo feminino apresentam maior crescimento no período pré-púbere e menor crescimento durante a puberdade, fato consistente com estudos anteriores. Porém, essas pacientes não apresentam ganho de peso após a menarca, contrariando a literatura. Nos pacientes do sexo masculino, a gravidade do IMC não impactou a IC de entrada na puberdade, tendo este reduzido ao longo da puberdade. Em nenhum dos grupos houve perda de estatura final.
Machismo high-tech: a objetificação da mulher como instrumento brutal de garantia de sua submissão na era digital
Authors: Tasca Mariana Silvério Almeida e
Published: May 2022

Este artigo pretende apresentar uma nova forma de discriminação de gênero, manifestada por meio da dominação interpessoal, existente dentro dos espaços virtuais: a exposição não consentida da intimidade sexual, que se desdobra em três espécies. Para tanto, realizou-se uma pesquisa bibliográfica para identificar as extensões do machismo estrutural na sociedade brasileira e a forma como ele se apresenta em um mundo futurístico de especiais características, tais como o “anonimato”, a “amplificação”, a “permanência”, a ideia de “cativeiro virtual”, a “relativização de padrões éticos”, a “impunidade” e a “pseudoinvisibilidade do dano”. Constatou-se, sob um olhar jurídico, que os atuais instrumentos normativos voltados à proteção do tema ainda são deficientes, notadamente pelos efeitos deletérios na saúde mental das vítimas, o que sinaliza a importância do debate científico.
“Em mim não poço explicar que sou um colchão de pancadas…”: escritos de mulheres e escritos sobre mulheres na América Portuguesa
Authors: Vita Mariana Rodrigues de
Published: May 2022

O presente artigo tem como objetivo analisar a violência histórica pela qual as mulheres sofreram apagamento sendo sistematicamente secundarizadas no discurso histórico hegemônico. O artigo é resultado de uma pesquisa de iniciação científica alocada no Projeto Mulheres na América Portuguesa, o qual constrói um catálogo digital de documentação escrita por e de mulheres na América Portuguesa, logo, se utiliza de documentos que possibilitam analisar o cotidiano de grupos subalternizados, como os das mulheres. Entendidas nesse artigo como uma categoria social construída, desse modo, enquanto grupo, são lidas em conjunto devido à histórica opressão que as violenta, ou seja, como uma categoria política, e não de identidade. Sendo assim, a categoria teórica “mulher”, no singular, envolve diferentes classes, raças, orientações sexuais, etc., mas não intenta homogeneizar.
“Estamos trocando o pneu com o carro andando": educação escolar e ensino de história no meio rural em São Luiz do Paraitinga (SP) durante uma pandemia
Authors: Charleaux Laís Aparecida Faria
Published: May 2022

O presente artigo analisa os impactos da pandemia do COVID-19 no ensino e na educação destinado aos alunos moradores da zona rural da cidade de São Luiz do Paraitinga, localizada no interior de São Paulo, na região do Vale do Paraíba. Com o isolamento social, as escolas adotaram o ensino remoto como estratégia para dar continuidade ao aprendizado. Entretanto, essa nova forma apresenta grandes dificuldades sobre as quais apresentamos uma reflexão neste texto. Para investigar tal situação utilizou-se como fonte documental entrevistas realizadas com três professoras de História que atuam no município, as quais permitiram uma breve análise das estratégias usadas pelas escolas para ultrapassar algumas das adversidades impostas pelo contexto, principalmente no âmbito do ensino de História.
A escrita das sensações em Lavoura arcaica, de Raduan Nassar e Laços de família, de Clarice Lispector
Authors: Ayub Gibran
Published: May 2022

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A Religiosa de Diderot: entre inocência e ímpeto de liberdade
Authors: Leandro Renato Costa
Published: May 2022

Dentre as obras escritas por Denis Diderot, A Religiosa é um de seus romances mais inventivos e, por isso mesmo, polêmico. Nele, o filósofo expõe as práticas perversas e desumanas ocorridas nos claustros religiosos a partir do relato memorialístico de Suzanne Simonin, jovem obrigada a seguir o voto de clausura, mas que, contrariamente, deseja se libertar da opressora vida monacal. O ímpeto de liberdade da inocente Suzanne passa a ser entendido por ela mesma como uma revolução, visto que família, clero e Estado, quase em uníssono, impossibilitam-na de agir nessa direção. Partindo da relação entre o caráter inocente da protagonista e seu projeto revolucionário, o presente artigo pretende compreender o sentido de significação da noção de “inocência” elaborada por Diderot no romance ao verificar outros escritos do filósofo que também versam sobre as noções de “caráter natural” e “inocência”.
Drug Interactions Affecting Oral Anticoagulant Use
Authors: Mar Philip L. , Gopinathannair Rakesh , Gengler Brooke E. , Chung Mina K. , Perez Arturo , Dukes Jonathan , Ezekowitz Michael D. , Lakkireddy Dhanunjaya , Lip Gregory Y.H. , Miletello Mike , Noseworthy Peter A. , Reiffel James , Tisdale James E. , Olshansky Brian ,   from the American Heart Association Electrocardiography & Arrhythmias Committee of the Council of Clinical Cardiology
Published: May 2022

Oral anticoagulants (OACs) are medications commonly used in patients with atrial fibrillation and other cardiovascular conditions. Both warfarin and direct oral anticoagulants are susceptible to drug-drug interactions (DDIs). DDIs are an important cause of adverse drug reactions and exact a large toll on the health care system. DDI for warfarin mainly involve moderate to strong inhibitors/inducers of cytochrome P450 (CYP) 2C9, which is responsible for the elimination of the more potent S-isomer of warfarin. However, inhibitor/inducers of CYP3A4 and CYP1A2 may also cause DDI with warfarin. Recognition of these precipitating agents along with increased frequency of monitoring when these agents are initiated or discontinued will minimize the impact of warfarin DDI. Direct oral anticoagulants are mainly affected by medications strongly affecting the permeability glycoprotein (P-gp), and to a lesser extent, strong CYP3A4 inhibitors/inducers. Dabigatran and edoxaban are affected by P-gp modulation. Strong inducers of CYP3A4 or P-gp should be avoided in all patients taking direct oral anticoagulant unless previously proven to be otherwise safe. Simultaneous strong CYP3A4 and P-gp inhibitors should be avoided in patients taking apixaban and rivaroxaban. Concomitant antiplatelet/anticoagulant use confers additive risk for bleeding, but their combination is unavoidable in many cases. Minimizing duration of concomitant anticoagulant/antiplatelet therapy as indicated by evidence-based clinical guidelines is the best way to reduce the risk of bleeding.
Mapping Atrial Fibrillation After Surgical Therapy to Guide Endocardial Ablation
Authors: Bhatia Neal K. , Shah Rajan L. , Deb Brototo , Pong Terrence , Kapoor Ridhima , Rogers Albert J. , Badhwar Nitish , Brodt Chad , Wang Paul J. , Narayan Sanjiv M. , Lee Anson M.
Published: May 2022

BACKGROUND:

Surgical ablation for atrial fibrillation (AF) can be effective, yet has mixed results. It is unclear which endocardial lesions delivered as part of hybrid therapy‚ will best augment surgical lesion sets in individual patients. We addressed this question by systematically mapping AF endocardially after surgical ablation and relating findings to early recurrence, then performing tailored endocardial ablation as part of hybrid therapy.

METHODS:

We studied 81 consecutive patients undergoing epicardial surgical ablation (stage 1 hybrid), of whom 64 proceeded to endocardial catheter mapping and ablation (stage 2). Stage 2 comprised high-density mapping of pulmonary vein (PV) or posterior wall (PW) reconnections, low-voltage zones (LVZs), and potential localized AF drivers. We related findings to postsurgical recurrence of AF.

RESULTS:

Mapping at stage 2 revealed PW isolation reconnection in 59.4%, PV isolation reconnection in 28.1%, and LVZ in 42.2% of patients. Postsurgical recurrence of AF occurred in 36 patients (56.3%), particularly those with long-standing persistent AF (
P
=0.017), but had no relationship to reconnection of PVs (
P
=0.53) or PW isolation (
P
=0.75) when compared with those without postsurgical recurrence of AF. LVZs were more common in patients with postsurgical recurrence of AF (
P
=0.002), long-standing persistent AF (
P
=0.002), advanced age (
P
=0.03), and elevated CHA
2
DS
2
-VASc (
P
=0.046). AF mapping revealed 4.4±2.7 localized focal/rotational sites near and also remote from PV or PW reconnection. After ablation at patient-specific targets, arrhythmia freedom at 1 year was 81.0% including and 73.0% excluding previously ineffective antiarrhythmic medications.

CONCLUSIONS:

After surgical ablation, AF may recur by several modes particularly related to localized mechanisms near low voltage zones, recovery of posterior wall or pulmonary vein isolation, or other sustaining mechanisms. LVZs are more common in patients at high clinical risk for recurrence. Patient-specific targeting of these mechanisms yields excellent long-term outcomes from hybrid ablation.