bluuebunny/crossref_metadata_2025 huggingface dataset:
Partially absorbable composite mesh versus non-absorbable polypropylene mesh in laparoscopic repair of inguinal hernia in a tertiary care center
Authors: Gohil Rohit , Nayak Tapan , Mahapatra Sanjay , Sarkar Dibakar , Kujur Sanjay , Dash Saroja
Published: March 2024

Background: The choice of mesh is far more important than the technique used as a determinant of patient outcome. Randomized studies have compared polypropylene and modified composite mesh (polypropylene and polyglactin) and found decreased foreign body reactions and post-operative complications and improved long-term quality of life with the use of composite mesh. However, a limited number of studies have been done comparing the early outcomes such as inguinodynia, the presence of a seroma or hematoma, foreign body sensation, testicular problems, and the return to normal work activities.

Aims and Objectives: The primary objective was to assess and compare the early outcome of non-absorbable polypropylene mesh vs. partially absorbable composite mesh in laparoscopic inguinal hernia repair. The secondary objective was to compare the complications associated with both types of mesh hernioplasty.

Materials and Methods: A total of 50 cases of elective reducible indirect inguinal hernia patients admitted to the Department of Surgery, VIMSAR, Burla, were included in our study. The total group was split into Group A and Group B of 25 cases each. All patients underwent laparoscopic inguinal hernia repair transabdominal prepeitoneal. The partially absorbable composite lightweight meshes are used in Group A, and the non-absorbable polypropylene meshes are used in Group B. After surgery, comparison between the two groups was made on the basis of parameters such as age distribution, inguinodynia, analgesia, foreign body sensation, presence of a lump (hematoma or seroma), return to work activities, and recurrence.

Results: The mean age of patients is 50.24 ± 12.994 years. The majority of the patients were in the age group of 51–60 years. Initially, there was no significant difference in transient neuralgia between the two groups, but after 6 weeks, Group A had significantly less pain. Foreign body sensation is significantly more in Group B, but later, this was not significant.

Conclusion: Based on the results of this study, composite mesh may be recommended for use in laparoscopic inguinal hernia repair owing to the less pain, less foreign body sensation, and earlier return to work.
Bullous pemphigoid associated with the use of DPP4 inhibitors: A case series
Authors: Saha Manali , Bandyopadhyay Mriganka , Mandal Ananya , Ghosh Arijit , Mandal Pragnadyuti , Chattopadhyay Suman
Published: March 2024

Dipeptidyl-peptidase 4 (DPP-4) inhibitors are one of the most commonly used anti-diabetic drugs because of their established safety and efficacy. Bullous pemphigoid which is an autoimmune blister skin disorder associated with DPP-4 inhibitors is a recognized adverse drug reaction (ADR) reported in some Southeast Asian Nations but has not been reported earlier from India. It is an uncommon, serious treatment with emergent adverse effects. Here, we report a series of five cases of DPP-4 inhibitor Linagliptin-induced bullous pemphigoid reaction in Type 2 diabetes mellitus patients. We are reporting five cases that showed various clinical manifestations in terms of gender (males 4), duration of diabetes (average 7.2 years), glycemic control (average HbA1C 6.7%), and latency period (average 3.6 weeks) for development of the ADR. Quality of life and treatment satisfaction were severely impacted by this ADR. Withdrawal of Linagliptin, use of topical and oral steroids and immunosuppressant like azathioprine were prescribed and effective for improving the lesions of all the cases. As per the World Health Organization-Uppsala Monitoring Center scale, causality was established as “probable” for all the cases. This case series serves to bring to the notice of prescribers regarding this important cutaneous ADR with the use of Linagliptin. This case intends to improve awareness among clinicians regarding the possibility of this cutaneous ADR among diabetic patients to facilitate early diagnosis and intervention.
Outcomes Comparison: Conservative and Surgical Treatments for Early Recurrent Lumbar Disc Herniation
Authors: Dogu Huseyin
Published: March 2024

Introduction: This study aimed to evaluate the outcomes of surgical and conservative treatments for early recurrent lumbar disc herniation, addressing a gap in current clinical understanding.
Material and Method: Patients who underwent single-level microdiscectomy between 2006 and 2023 and experienced recurrence within six months were retrospectively analyzed. They were divided into surgical and conservative treatment groups, and demographics, recurrence characteristics, and functional outcomes were assessed. Functional outcomes were measured using the Visual Analog Scale (VAS) and the Oswestry Disability Index (ODI).
Results: Of the 75 cases studied, 76% opted for repeat surgery, while 24% pursued conservative treatment. There were no significant differences in demographics or recurrence characteristics between groups (p > 0.05). Initial VAS and ODI scores were significantly higher in the conservative treatment group compared to the surgical group (p = 0.001; p < 0.01), but no significant differences were observed at the 6-month follow-up (p > 0.05). Despite the earlier recovery experienced by patients undergoing surgery, there were no discernible differences in outcomes between surgical and conservative treatments in the later stages of recovery.
Conclusion: This study underscores the importance of considering both surgical and conservative approaches in managing early recurrent lumbar disc herniation, offering insights into treatment outcomes and recovery trajectories.
Beijing 1995 and female terrorism in 21st century West Africa
Authors: Chinedu U Udumaga Cornel , Chizoba Nwaoha Chimaroke
Published: March 2024

This article examines the relationship between the 1995 World Conference on Women held in Beijing and the emergence of female terrorism in West Africa during the 21st century. It examines how the conference, which was intended to promote global gender equality and women's rights, unintentionally influenced the dynamics of female participation in extremist activities. This study provides insights into the motivations, strategies, and effects of female terrorism in West Africa by analysing historical events, regional context, and socio-political factors, casting light on the complex relationship between gender, empowerment, and violence. The gendered socialisation theory served as the theoretical framework for this study. Noting that the study is qualitative and non-experimental, a descriptive research design was chosen for this investigation. The qualitative method was used to generate data for this study, and the qualitative descriptive method was used to analyse the collected data. The study revealed a correlation between the 1995 World Conference on Women in Beijing and the rise of female terrorism in West African nations. The study recommended adequate public enlightenment, strengthened responsive counterterrorism strategies, enhanced women’s participation in counterterrorism efforts and genuine empowerment of women and girls through education and economic opportunities.
Green marketing: A descriptive analysis of its influence on consumer buying behavior and green marketing practices
Authors: Paul Atul  Kumar , Doley Atul
Published: March 2024

In the current era of climate change, people worldwide are increasingly concerned about the environment and its impact. Therefore, this paper aims to look into the behaviour of consumer regarding sustainable products and the implementation of green marketing practices in Barpeta district. The research put to use both the primary and the secondary data. The primary data was accumulated from 90 respondents in Barpeta District using a simple random sampling method. The study is being conducted from 2022 to December 2023. Various statistical tools such as weighted score, mean, rank analysis, and Chi-square test are employed to study the data. The findings could not find any significant difference in awareness of sustainable products based on age or education level. Similarly, gender does not play a significant role in influencing awareness of green products and marketing practices related to the environment. However, there is a significant difference in awareness of sustainable products based on employment status and income level. Based on the rank analysis, six variables are identified as significant factors influencing awareness of sustainable products and marketing practices related to the environment. These findings provide valuable insights to draw meaningful conclusions from the study.
The logic of change in the "rebalancing" of supply and marketing cooperatives
Authors: Qiao Kezhuo
Published: March 2024

Supply and marketing cooperatives are an important part of China's rural cooperative economy, playing a pivotal role in the country's economic construction and social stability. Based on the analytical framework of historical institutionalism, through combing the historical trajectory of supply and marketing cooperatives, it is found that its change mode and path of change present the logic of "equilibrium-fracture-re-equilibrium" under the joint action of endogenous power and strong factors, and the interaction of the institutional environment, institutional structure, institutional concepts, and political actors constitutes the driving mechanism of the change of supply and marketing cooperatives system. The interaction of institutional environment, institutional structure, institutional concept and political actors constitutes the power mechanism of supply and marketing cooperative system change. In the context of the new era, the supply and marketing cooperative system under the trend of "rebalancing" has become an important content of rural governance, and through the "re-embedding" of the governance process and the collaborative innovation of multiple subjects, it helps to make the supply and marketing cooperatives enter into a new benign change track and realize the long-term sustainable development of the system. The long-term sustainable development of the system can be realized through the "re-embedding" of the governance process and the collaborative innovation of multiple subjects.
Research on the effect of e-commerce adoption in improving farmers' income and welfare in the context of digital economy
Authors: Zhang Huimin
Published: March 2024

In the era of digital economy, e-commerce, as an important economic model with the characteristics of the times, has a profound impact on the development of rural economy, and e-commerce of agricultural products has become a new driving force to promote agricultural industrialization, digitalization and increase farmers' income. Considering the sample selection bias and endogeneity, this paper uses multiple regression model to benchmark and two-stage regression to measure the effect of e-commerce participation on the improvement of farmers' business performance, and finds that the adoption of e-commerce of agricultural products is helpful to increase agricultural income, but it is not as significant as the impact of land area, and even less than the factors affecting income such as labor force and brand building. However, the positive impact of the adoption of e-commerce of agricultural products on farmers' income will increase with the deepening of their e-commerce adoption, especially in the later stage, and the network scale effect will be gradually released.
Research on Tax Policies to Promote Agricultural Modernization Development
Authors: Dai Yiming
Published: March 2024

Agriculture constitutes a fundamental sector of national economic development, and the steady growth of agriculture-related industries has contributed significantly to job creation and increased value output in the Chinese economy. The central government has consistently prioritized the healthy and sustainable development of agriculture, implementing various policies to support agricultural enterprises in enhancing their market competitiveness. This includes a wide range of tax support measures. On the other hand, the effectiveness of policy incentives in encouraging enterprises to improve their operations is unclear, given that most agricultural enterprises in the country face challenges such as small size, outdated information, weak management capabilities and poor resistance to market risks and uncertainties. This paper aims to examine the role of tax policy in the industrialised management of the agricultural sector. This paper seeks to provide new insights into governance in this area by exploring the moderating role of tax policies on the relationship between Chinese agribusinesses and their management. The findings will provide policy makers with responsible recommendations for enhancing the effectiveness of tax policies and other agriculture-related policies.
Percolation connectivity in deposits obtained usingcompetitive random sequential adsorption of binarydisk mixtures
Authors: Lebovka N. I. , Petryk M. R. , Vygornitskii N. V.
Published: March 2024

Connectedness percolation phenomena in the two-dimensional (2D) packing of binary mixtures of disks with different diameters were studied numerically. The packings were produced using random sequential adsorption (RSA) model with simultaneous deposition of disks. The ratio of the particle diameters was varied within the range D=1-10, and the selection probability of the small disks was varied within the range 0-1. A core-shell structure of the particles was assumed for the analysis of connectivity. The packing coverages in a jamming state for different components, connectivities through small, large and both types of disks, the behavior of electrical conductivity were analyzed. The observed complex effects were explained accounting for the formation of conductive "bridges" from small disks in pores between large disks.
Загальна характеристика та класифікація рішень митних органів
Authors: Дрофіч О. Ю.
Published: March 2024

У статті розкрито загальну характеристику рішень митних органів та наведено основні критерії класифікації рішень митних органів для поглиблення розуміння сутнісних та другорядних характеристик рішень митних органів у їх різноманітті. Методологічна основа статті включає аналіз, синтез та узагальнення, а також метод абстрагування та нормативно-догматичний метод. За підсумками дослідження визначено, що рішенням митних органів притаманні такі властивості: 1) видання на виконання повноважень митних органів щодо реалізації положень митного законодавства; 2) породження, зміна або припинення прав та обов’язків конкретних підприємств та фізичних осіб у митній сфері; 3) встановлення юридичних наслідків для конкретних підприємств та фізичних осіб; 4) вираження собою обраного митним органом шляху застосування митного законодавства у конкретному випадку та його одноразове застосування; 5) спрямованість на збалансоване одночасне досягнення фіскальних, безпекових та регуляторних цілей діяльності митних органів. Одночасно з цим, запропоновано класифікувати рішення митних органів, насамперед: 1) за походженням ініціативи щодо їх прийняття; 2) залежно від характеру впливу рішень митних органів на волю та поведінку підприємств чи фізичних осіб; 3) за характером впливу рішень митних органів на права та обов’язки підприємств чи фізичних; 4) за характером їх впливу на права та обов’язки підприємств чи фізичних осіб на: рішення митних органів публічно-сервісного спрямування, публічно-владні управлінські рішення митних органів неделіктного характеру (у тому числі дозвільного характеру, фіскального характеру, контрольного характеру та деліктні рішення митних органів). Стаття має теоретичний характер.
تقييم الأنشطة اللغوية في مقرر لغتي الخالدة للصف الثالث المتوسط في ضوء مهارات القراءة التأملية
Authors: العتيبي انجود عبيد
Published: March 2024

هدف البحث الحالي إلى التعرف على درجة توافر مهارات القراءة التأملية المتعلقة (بالتنبؤ – الاستقصاء - الاستنتاج – الفحص (التأمل) – التحليل)؛ لتحديد مدى تضمنها في أنشطة كتاب لغتي الخالدة للصف الثالث المتوسط في المملكة العربية السعودية.

وصممت وطبقت الباحثة قائمة مهارات القراءة التأملية اللازم توافرها في أنشطة مقرر لغتي الخالدة للصف الثالث المتوسط والمكونة من (5) مهارات رئيسة يندرج تحتها (26) مهارة فرعية. كما أعدت الباحثة بطاقة تحليل المحتوى لتحليل (19) نص قرائي تضمنت (162) نشاطا لغويا كعينة للتحليل في (6) وحدات.

وأظهرت النتائج أن نسبة مراعاة أنشطة مقرر لغتي الخالدة لمهارات التنبؤ (8,40) وهي نسبة ضعيفة جدا، كما أن نسبة مراعاة أنشطة مقرر لغتي الخالدة لمهارات الاستقصاء (25,21) وهي نسبة متوسطة، وأن نسبة مراعاة أنشطة مقرر لغتي الخالدة لمهارات الاستنتاج (40,34) وهي أعلى نسبة، ونسبة مراعاة أنشطة مقرر لغتي الخالدة لمهارات الفحص والتأمل (16,81)، وهي نسبة ضعيفة، وأخيرا نسبة مراعاة أنشطة مقرر لغتي الخالدة لمهارات التحليل (9,24) وهي نسبه ضعيفة.

وفي ضوء هذه النتائج قدمت الباحثة عددا من التوصيات والمقترحات.
دور الأسرة في تنمية الأمن الفكري لدى الأبناء على ضوء تحديات العصر الرقمي من منظور إسلامي
Authors: الدوسري نوف محمد هضيبان
Published: March 2024

هدفت هذه الدراسة إلى التعّرف على واقع دور الأسرة في تعزيز الأمن الفكري لدى الأبناء في الجوانب العقدية والتعبدية من وجهة نظر طلاب المرحلة الثانوية في مدينة الرياض، ودور الأسرة في تعزيز الأمن الفكري لدى الأبناء في الجوانب الأخلاقية في ضوء العصر الرقمي من وجهة نظر أولياء الأمور لطلاب المرحلة الثانوية في مدينة الرياض، والكشف عن درجة توافر آليات الأسرة في مواجهة مخاطر العصر الرقمي على الأمن الفكري لأبنائها؛ ولتحقيق ذلك تم تصميم استبانة مكونة من (25) عبارة موزعة في ثلاثة محاور، بعد أن تم التأكد من صدقها وثباتها وفق الإجراءات المتبعة للتأكد من صدق وثبات الأداة، باتباع المنهج الوصفي التحليلي بمدخله المسحي، لجمع البيانات من عينة الدراسة البالغة عددها (120) فرد من أولياء أمور طلاب المرحلة الثانوية بمدينة الرياض، اختيروا بالطريقة العشوائية الطبقية، وأظهرت النتائج أن واقع دور الأسرة في تعزيز الأمن الفكري لدى الأبناء في الجوانب العقدية والتعبدية من وجهة نظر أولياء أمور طلاب المرحلة الثانوية في مدينة الرياض جاء مرتفع جدًا، حيث بلغ المتوسط الحسابي (الكلي) لاستجابات أولياء الأمور على محور واقع دور الأسرة في تعزيز الأمن الفكري لدى الأبناء في الجوانب العقدية والتعبدية (4.39) وانحراف معياري (0.87)، وأن واقع دور الأسرة في تعزيز الأمن الفكري لدى الأبناء في الجوانب الأخلاقية في ضوء العصر الرقمي من وجهة نظر أولياء الأمور لطلاب المرحلة الثانوية في مدينة الرياض جاء مرتفع جدًا، حيث بلغ المتوسط الحسابي الكلي لاستجابات أولياء الأمور طلاب المرحلة الثانوية في مدينة الرياض على محور واقع دور الأسرة في تعزيز الأمن الفكري لدى الأبناء في الجوانب الأخلاقية في ضوء العصر الرقمي (4.26) وبانحراف معياري (0.90)، بينما جاءت درجة آليات الأسرة في مواجهة أخطار العصر الرقمي على الأمن الفكري لأبنائها متوسطة، حيث بلغ المتوسط الحسابي (الكلي) لاستجابات أولياء الأمور لطلاب المرحلة الثانوية في مدينة الرياض على محور درجة آليات الأسرة في مواجهة مخاطر العصر الرقمي على الأمن الفكري لأبنائها (2.58) وانحراف معياري (0.85)، وقدمت الدراسة بعض الاقتراحات والتوصيات بناءً على نتائجها.
مصطلح "في حديثه صنعة" عند الإمام أبي حاتم في كتاب الجرح والتعديل (جمعًا ودراسةً)
Authors: الشهراني أمل بنت عبد الله بن سيف
Published: March 2024

نقل ابن أبي حاتم عن أبيه كثيرًا من الأحكام على الرواة في كتابه "الجرح والتعديل"، منها قوله: "في حديثه صنعة". أتكلم في هذا البحث عن هذا الإطلاق، فما مفهومه عنده؟ وهل وافق الأئمة أم خالفهم في مقصده منها؟

استعمل الإمام هذه العبارة مع ستة من الرواة، ثلاثة منهم أخرج لهم في الكتب الستة، وثلاثة في غيرها.

استعنت في كتابة هذا الموضوع بالمنهجين: الاستقرائي والمقارن، قسمته بعد المقدمة، إلى مبحثين، خصصت الأول للكلام عن المسائل النظرية، وتناولت في الثاني الجوانب التطبيقية لهذا الموضوع.

وتبين لي في نتائج البحث، ومن خلال النظر في هؤلاء الرواة، ورواياتهم، دقة الإمام أبي حاتم في إطلاقه هذا المصطلح، واستعماله للإشارة إلى ما في حديث الراوي من وضع واختلاق، وأن ما يرويه ليس من كلام النبي ، وإنما حدث فيه تغيير، كما تبين لي موافقته لغيره من النقاد في دلالته عنده، وإن كانت عبارته تختلف عن إطلاقاتهم.
المشيرات الاجتماعية في الخطاب السياسي: خطاب ولي العهد السعودي محمد بن سلمان نموذجًا
Authors: السلطان عبد الله عبد العزيز
Published: March 2024

يهدف هذا البحث إلى دراسة دور المشيرات الاجتماعية في الخطاب السياسي من خلال رصد بنيتها المعجمية والدلالية وتوظيفها التداولي في توجيه مقاصد المتكلم وبيان مواقفه من القضايا المطروحة للمناقشة، وبيان درجة التفاعل بين المتخاطبين وتعاطفهم وهي أمور تكشف عن طبيعة العلاقة بين المتكلمين ومدى نجاح عملية التواصل بينهم. ومن خلال معالجتنا للمشيرات الاجتماعية سعينا إلى أن نوضح أثرها في خطاب ولي العهد السعودي محمد بن سلمان، وذلك وفق الآليات اللسانية والتداولية، خاصة المباحث المهتمة بالمشيرات وعلاقتها بالمتكلم وبالخطاب؛ واعتمدنا في ذلك على المقاربة التداولية لبنفنيست في تحليل دور المشيرات الاجتماعية في الخطاب السياسي. فتوصلنا إلى أنَّ المشيرات الاجتماعية تأتي في الخطاب في أشكال مختلفة مثل الضمائر وأسماء الإشارة، والصفات والألقاب، وألفاظ التحيات والوداعيات، وقد استخدمها ولي العهد في خطابه وفق إستراتيجيات خطابية ينبئ بها عن طموحاته وتطلعاته وغاياته في بناء علاقة مستقبلية مع دول مجلس التعاون الخليجي.
Multiracial Multilinguals: How Language Influences Multiracials’ Interpersonal Relationships
Authors: Hernandez Elizabeth , Pauley Taylor , Zheng Haochen , Jubera Kaitlyn , Perreyclear Torin , Vera Rosi , Satchwell Margaret , Willis Jarryd
Published: March 2024

Lovers in interracial couples are more likely to have different heritage languages and first languages than same-race couples, and Multiracials are the offspring of interracial couples. As such, Multiracials’ linguistic socialization likely differs from that of monoracials. Our study examined the influence of ethnoracial socialization on monoracials’ and Multiracials’ linguistic knowledge and the influence of language and ethnoracial identity on individuals’ interpersonal relationships. We hypothesized that monoracials would be more likely to know their heritage language than Multiracials, that linguistic knowledge would differ between interminority Multiracial groups and half-White Multiracial groups, and that linguistic knowledge would be associated with the formation of both friendships and romantic relationships. Our sample included nearly a thousand students from a university in California. We found that monoracial minorities were more likely to be multilingual than both interminority Multiracials and half-White Multiracials. East Asian participants who spoke an East Asian language had a higher proportion of East Asian friends. Among Multiracials, Wasians and Latinasians who spoke an East Asian language primarily dated someone East Asian, Latinasians who spoke a Latin American language primarily dated someone Hispanic, and monolinguals of both groups were the ones most likely to date someone White. These findings suggest that linguistic knowledge plays a significant role in a community's social dynamics, affecting monoracials' and (especially) Multiracials' interpersonal relationships.
Research on the Adaptability of Packers for Integrated String Fracturing Operations in Low Porosity and Low Permeability Reservoirs
Authors: Wan Zhiyong , Yu Hao , Xiao Yong , Zhao Zhaoyang , Lian Zhanghua , Chen Fangxin
Published: March 2024

To study the failure of conventional packers in the fracturing and stimulation of low-porosity and low-permeability reservoirs and reduce the failure accidents of packers in the fracturing process, a suitable integrated string packers was selected in the process of fracturing and stimulation in an oilfield in the Middle East as a case study. Three different well types have been established. The wellbore temperature distribution and the axial force of the string can be calculated under the conditions of various wellhead pressures and different displacement, and it is found that the temperature at the bottom of the well can reach 130 °C, and the maximum axial force at the wellhead is 500 kN. At the same time, the applicability of retrievable tubing testing squeeze (RTTS) and hydraulic-set retrievable (RH) packer in different working conditions was evaluated, and it was found that only RTTS packers can meet the needs of the oil field. According to the calculated temperature field and axial force distribution, the stress on different components of the packer under different working conditions is established during the fracturing-stimulation operation. In the worst working conditions, the maximum stress of the packer occurs at the lower part of the central pipe, reaching 303.83 MPa, which is in a safe state. The contact stress on rubber rings can reach 30 MPa, indicating that the sealing performance can meet the requirements of on-site use. The temperature and axial force data calculated by the model provide a theoretical basis for safe well control. Through model evaluation, it was found that the RTTS packer can be suitable for the fracturing and stimulation needs of the oilfield. The research methods and achievements in the article provide theoretical guidance for evaluating the applicability of packers in the fracturing and stimulation process of low porosity and low permeability reservoirs.
The impact of credibility of streamers on the acceptance of live streaming commerce: An extended UTAUT model
Authors: Ng Alex Hou Hong , Wider Walton , Ho Ree Chan , Wong Chee Hoo , Ngui Kwang Sing , Bien Jonna Karla
Published: March 2024

This study aims to explore how innovation adoption, based on the Unified Theory of Acceptance and Use of Technology (UTAUT), influences online shopping through live streaming platforms. It focuses on understanding the factors that drive customer acceptance and usage behavior in the context of live streaming commerce. The research employed a quantitative methodology, utilizing a survey instrument to collect data. The participants comprised 237 online customers in Malaysia who were familiar with live streaming as a shopping medium. The SmartPLS software, which is a tool for structural equation modelling, was utilized for data analysis. The findings suggest that performance expectation, effort expectancy, and social influence, which are important components of the UTAUT theory, have a considerable impact on consumer acceptance and usage behaviour in live streaming commerce. Additionally, the credibility of streamers emerged as a critical factor influencing purchase intentions. These findings highlight the importance of streamer credibility in the live streaming shopping experience. This research offers valuable insights for online retailers and businesses utilizing live streaming platforms for commerce. Understanding the factors that encourage customer engagement and purchase can help in strategizing marketing and operational approaches. It also suggests that the streamers' credibility is a vital aspect of the shopping experience, pointing towards the need for selecting and training streamers effectively. Moreover, this study extends the applicability of the UTAUT theory to live streaming commerce, providing a framework for further research in this emerging field.
In-silico studies and docking of n-substituted isoindoline-1, 3-dioine analogues as
anti-proliferative agents
Authors:   University Institute of Pharmacy,
            Pt. Ravi shankar Shukla University, Raipur, Chhattisgarh, India, Saraf Shailendra
Published: March 2024

Recently,isoindoline-1,3-dione compounds based folpet, phosmet, captonand
thalidomide were developed because they have a comparable degree of anti-proliferative
efficacy owing to their diverse mechanisms such as HDAC inhibitors, tryptase inhibitors,
inhibits the mode of tnf-α, and angiogenesis inhibitors. It was investigated how the
phthalimide pharmacophore interacted with molecules such tnf-α, HDAC, VEGF, EGF, and
Tyrosine Kinase Angiogenesis. In order to assess the inhibitory activity against enzyme
assay, a series of phthalimidepharmacophores with various substituent’s (Schiff's base)
at the N-phenyl ring were submitted to protein-ligand docking investigations using the
lib-dock method in the current work. All of the compounds' chemical structures were
designed using Cambridge software, ChemBioOffice Ultra 12.0, and their molecular
characteristics were determined using the online molecular modelling tool
Molinspiration. Utilizing the Discovery Studio Client version 4.1, ADMETlab 2.0, and
Lazar 1.4.2 softwares, ADME, Toxicity, and Molecular Docking investigations using the
lib-dock method were carried out to evaluate the binding mode and interactions of
synthetic hits at the binding site of receptors. Docking studies demonstrated that these
sorts of ligands interacted mostly with TNF-α, HDAC, VEGF, EGF, Tyrosine kinase, and
angiogenesis reports, among others, by forming hydrogen bonds and interacting
hydrophobically with the domain. Our docking results indicate that compounds A1, A10,
A11, A22, A26, and A28 demonstrated the greatest binding affinity with the corresponding
proteins based on the predicted binding energy. These computer simulations have shown
that phthalimide compounds with N-phenyl rings replaced can effectively suppress
enzymatic assay.
Characterization and molecular docking studies of Erucic acid
Authors:   School of Medical and Allied
            Sciences, K.R. Mangalam University, Gurugram, India, Sharma Bhawna
Published: March 2024

Neuro degenerative diseases (NDs) are a wide range of neurological conditions
characterized by the deterioration of neurons, glial cells, synapses, and other
networks. Parkinson’s disease is one of the second most common neuro degenerative
disorders after Alzheimer’s disease. Erucic acid, an omega-9 monounsaturated fatty acid,
was reported to be commonly present in mustard oil. Erucic acid was also reported to
have neuro protective and antioxidant benefits in a number of pre-clinical trials
conducted in the past. In the present study, erucic acid, linoleic acid, and Riluzole
were evaluated using a molecular docking-based technique based on their binding
affinities and other physico-chemical characteristics of the compounds. PYRX 0.8 was
used for molecular docking between ligands and the various antioxidant and
neurotransmitter-associated proteins, and Discovery Studio Visualizer 2020 was used to
create the visualization. Additionally, Lipinski's rule of five was used to forecast
whether these compounds would be drug-like. Further absorption, distribution,
metabolism, excretion, and Toxicity (ADME-T) profile of the compounds were studied using
the pkCSM tool. According to drug-likeness analysis, all of the compounds i.e. erucic
acid, linoleic acid, and Riluzole fell within Lipinski's rule of five's acceptable
range. The docking studies implied that erucic acid might have anti-parkinsonian effects
by binding to molecular targets superoxide dismutase (SOD1) enzyme protein i.e. 5YTU and
to 5-Hydroxytrytamine (5H2TC) receptor protein i.e. 6BQH when compared to Riluzole along
with good ADME-T properties. However, more research is needed to evaluate the efficacy
of erucic acid against additional targets of Parkinson’s disease and other neuro
degenerative illnesses.
Osseo-densification for preservation and compaction of alveolar bone in enhancing
stability of dental implants: A systematic review
Authors:   Pacific dental college and
            research centre, Pacific academy of higher education and research university, Udaipur,
            Rajsthan, India, Jamal Sayed Arshad
Published: March 2024

A higher implant failure rate may be associated with a lack of primary stability.
Primary stability is a stationary, entirely mechanical parameter that determines when an
implant is placed. Several methods have been developed to improve the primary implant's
level of stability. However, Osseo-densification (OD) is a revolutionary implant
preparation approach that addresses these issues and enhances the main stability of
implants inserted into low-density bones. In light of this, the present systematic
review was conducted to understand the Osseo-densification for preservation and
compaction of alveolar bone in enhancing the stability of the dental implant. Research
papers from PubMed, CINAHL, Web of Science, and Web of Science, Medline searched. The
most recent literature suggests that using the Osseo-densification drilling protocol
increases the overall value of implant insertion torque and, consequently, increases the
primary stability of implants. To evaluate the caliber of the contained research, CARE,
ARRIVE, and modified CONSORT checklists were employed. 133 full texts were chosen for
further investigation after duplicates were removed and titles and abstracts were
reviewed of these, 27 entire texts met the inclusion criteria. The thorough literature
search identified 6 Case Studies & Case Series, 11 in vivo animal studies, and ten
/experimental animal studies that noted the use of the Osseo-densification technique.
The data from most recent animal in vivo/in vitro studies and case reports / case series
suggest that Osseo-densification drilling protocol increases the overall value of
implant insertion torque and, as a result, increases implant primary stability.
Assessing the toxicity and anti-anemia of Beta Vulgaris L.: in silico,
phytochemical and antioxidant analysis
Authors:   Department of Pharmaceutical
            Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan,
            Indonesia, Nugraha Sony Eka
Published: March 2024

The objective of this investigation was to determine the toxicity, anti-anemia
activity, betanin content, flavonoid content, and antioxidant capacity of Beta vulgaris
L. Microwave-assisted extraction (MAE) was implemented to optimize the extraction
procedure. The total phenolic content (TPC) and total flavonoid content (TFC) of the
extracts were determined using the Folin-Ciocalteu colorimetric and aluminum chloride
methods, respectively. Furthermore, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method was
employed to ascertain antioxidant capacity, whereas thin-layer chromatography was used
to identify betanin content. The toxicity and anti-anemia properties were assessed in
silico. The in-silico methods encompass several steps: ligand and target protein
synthesis, docking of betanin compounds with the erythropoietin receptor (EpoR) target
protein via SwissDock, docking data visualization via USCF Chimera, and toxicity
analysis via the pkCSM and Protox online tools. The findings indicated that the beetroot
extract contained a total of 34.96 ± 3.97 mg GAE/g sample of phenol. The flavonoid
content of beetroot was 4.93 ± 0.33 mg QE/g sample. Qualitative analysis conducted using
thin-layer chromatography yielded results indicating the presence of betanin in the
extract. The IC50 value for the antioxidant activity was 97.31 μg/ml. The docking study
revealed the effective interaction of betanin with several amino acid residues,
suggesting a low toxicity potential, supported by toxicity class 4 and an LD50 of 305
mg/kg, and the absence of liver and Ames toxicity. It concluded that betanin is a
promising anti-anemia agent. levels.
Network ethnopharmacological and molecular docking based evaluation of the
anti-breast cancer activity for ayurvedic botanicals acting on hypoxia-inducible
factor-1
Authors:   Faculty of Pharmacy, Bharati
            Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India, Bhatia Neela M
Published: March 2024

The recognized root causes of breast cancer aggressiveness, resistance to therapy,
and poor prognosis encompass hypoxia-inducible factors (HIFs), the HIF-dependent cancer
hallmarks angiogenesis and metabolic reconfiguration.There is enough evidence to suggest
that HIF is involved in the progression of breast cancer.Information for the network was
gathered from the following databases: Dr. Duke's, IMPPAT, PubChem, Binding DB, UniProt,
and DisGeNET. The network was created using the Cytoscapeprogramme. Screened bioactives
having similarity index more than 0.6 from polypharmacology approach were subjected to
docking studies with HIF-1 (PDB ID: 1H2K) with PyRx software and the ligands with good
docking score was further explored for molecular docking interaction analysis. The
number of bioactives having interaction with HIF-1, equal to or greater than 0.6 from
Ashwagandh, Shatavari, Neem, Alsi seeds, Methi, Haldi, Ghritkumari, Yashtimadhu, and
KadiPatta was 12, 9, 2, 6, 12, 11, 5, 10, and 3, respectively. On performing the docking
against the target HIF-1for top molecules with Araboglycyrrhizin (-10.1kcal/mol),
Asparanin-A (-9.2 kcal/mol), Shatavarin-I (-9.2 kcal/mol), Shatavarin-X (-9.1 kcal/mol),
Somniferanolide (-9.1 kcal/mol), Somniferawithanolide (-9.7 kcal/mol), Trigofoenoside-A
(-9.2 kcal/mol), Trigofoenoside-F (-9.4 kcal/mol), Trillin (-9.9 kcal/mol), and
Withanolide (-9.2 kcal/mol), the binding energies and molecular interactions of the
ligands were fairly good as compared with standard synthetic ligand Acriflavine (-7.6
kcal/mol). The study elucidated an in silico molecular mechanism of HIF-1 inhibition by
various bioactive phytoconstituents from selected plants. Comprehending the logic behind
anti-breast cancer action was made easier with the help of experimental evidence of the
network findings.
Comparative morpho-anatomical studies of Albizia lebbeck (L.) Benth and in vitro
micro propagated plantlets
Authors:   Department of Biotechnology,
            Vignan’s Foundation for Science Technology and Research, (Deemed to be University) Andra
            Pradesh, India, Bobby Md. Nazneen
Published: March 2024

The current investigation was characterizing the pharmacognostical screening of
the mother plant Albizia lebbeck and its in vitro propagated plantlets. The macroscopic
analysis showed the presence of various parts of the plants and the anatomical studies
revealed the presence of paracytic stomata of equal subsidiary cells; dendroid vein
terminations; Thick–walled epidermal cells and parenchymatous ground tissue; cuticular
projections with striations in the epidermal cells of a leaf; smaller vascular bundles
with lateral veins; thick-walled bundle sheath fibers with thick vascular strands;
irregularly lobed sclereids and tannin cells in the upper epidermis of lamina; druse
idioblasts in the mesophyll of the leaf; accessory vascular bundles in the petiole were
observed in the mother plant, which was compared with the in-vitro micro propagated
plantlet with the presence of thick and wide midrib with lamina; Thick leaf margin with
thin Phloem; short xylem; vascular showed reduced in size; Reduce palisade tissue; Thick
and compact parenchyma; Squamish and papillate epidermal cells were observed in
epidermal and stromata region. The current studies contribute as a standard monograph
for the identification and evaluation of plants.
ANALISIS PORTOFOLIO OPTIMAL SYARIAH PASCA COVID-19 MELALUI MODEL INDEKS TUNGGAL
Authors: Izzat Firdausi
Published: March 2024

Investasi merupakan upaya investor dalam mengorbankan konsumsi pada masa kini demi mendapatkan tingkat konsumsi lebih baik di masa depan. Untuk dapat memilih instrument investasi yang bagus yang dapat memenuhi ekspektasi para investor, diperlukanlah sebuah model seleksi saham terbaik. Saham-saham terbaik yang diseleksi menggunakan model indeks tunggal dan dikumpulkan dalam suatu wadah disebut dengan istilah portofolio optimal. Jakarta Islamic Index (JII) menjadi objek penelitian pada periode Januari 2020 hingga November 2023. Penelitian ini bertujuan untuk: Pertama, memberi gambaran dan saran mengenai pembentukan portofolio optimal berbasis model indeks tunggal setelah pandemi covid 19 pada indeks saham syariah di Indonesia khususnya JII. Kedua, mengetahui besaran bobot dana investasi pada masing-masing saham. Ketiga, mengetahui besaran return harapan dan risiko dari portofolio optimal saham. Hasil penelitian menunjukkan bahwa saham dengan kode ANTM dan TPIA merupakan saham terbaik dan layak masuk portofolio optimal. Besaran proporsi dana yang perlu dialokasikan dalam investasi adalah 93% pada ANTM dan 7% pada TPIA. Dengan proporsi dana tersebut investor akan mendapatkan return sebesar 2,77% dan risiko sebesar 2,71% yang mana return dan risiko ini lebih baik dari return dan risiko indeks saham gabungan.
Mathematical Apparatus for Some Quality Indicators Assessment of a Training Webinar Using Machine Learning
Authors: Podkolzin V. V. , Poletaikin A. N. , Galkina M. Yu.
Published: March 2024

This article is the second stage of creating and researching a technology for assessing the quality of contact work at a university implemented through webinars. The mathematical support of the intelligent technology for analyzing the audio-video stream of an educational webinar recording is considered. The problem of increasing the efficiency and reliability of assessing some indicators of the quality of contact work at the Faculty of Distance Learning of SibSUTIS implemented through distance learning webinars is being solved. Machine learning methods and their implementation using standard Python modules and libraries are used for analysis. The scientific significance of the work lies in the development of new models and algorithms for intelligent analysis of audio-video streams parameterized for processing the recording of an educational event. The developed models and algorithms make it possible to increase the efficiency of the process of assessing the quality of contact work implemented through webinars.
Monte Carlo Simulation of Heteroepitaxial Growth of Ge on Pit-patterned Si(100) Substrate and Parallelization of Calculations
Authors: Rudin S. A. , Pavsky K. V. , Revun A. L. , Dvurechenskii A. V.
Published: March 2024

Methods and algorithms of Monte Carlo simulation of heteroepitaxial growth of Ge on Si are considered. The computational complexity analysis of simulation program blocks is carried out. Parallelization of time-consuming cycles using directives of the open standard OpenMP is proposed. The Monte Carlo simulation of heteroepitaxial growth of Ge on pitpatterned Si substrate was carried out. The position of Ge nanoislands is determined by the competition between the nucleation process of three-dimensional islands due to the accumulation of elastic strain in the growing layer and the process of diffusion of Ge atoms into the pits serving as a drain.
CURRENT PROBLEMS OF SUSTAINABLE USE OF TRANSBOUNDARY RIVERS OF KAZAKHSTAN
Authors:   Abai Kazakh National Pedagogical University, Abulgaziev A. G. , Zhandosova G. O. ,   Abai Kazakh National Pedagogical University, Zhumasheva A. Ye. ,   Abai Kazakh National Pedagogical University
Published: March 2024

The current state and forecast of water deficit in the world and actual issues of transboundary rivers use by Central Asian countries and Kazakhstan are considered. Analyzed actual for Kazakhstan issue of concluding effective and sustainable contracts in the use of transboundary rivers.
Recursos estratégicos
Authors: Comini da Silva Santana Adriana , Albuquerque Augusto Cleiciele
Published: March 2024

Objetivo do estudo: Compreender o potencial competitivo dos recursos humanos, físicos, organizacionais e financeiros presentes entre os segmentos de produção e processamento na cadeia produtiva de vinhos finos do Paraná.
Método: Realizou-se uma pesquisa qualitativa, descritiva, com recorte transversal. Utilizou-se como instrumento de coleta de dados três roteiros de entrevistas semiestruturadas para gestores de vinícolas, seus fornecedores e um dos representantes da VINOPAR.
Originalidade: Trata-se de um estudo que aplica a Visão Baseada em Recursos, junto ao modelo VRIO para identificar, descrever e entender as fontes de vantagens competitivas, por meio de recursos estratégicos, em uma cadeia que ainda não foi explorada nesse aspecto.
Principais resultados: Os achados mostram que as vinícolas têm diversos recursos estratégicos, entre eles, os recursos humanos (mão de obra, bom relacionamento, experiência dos gestores e funcionários), físicos (tecnologia, estrutura, localização, acesso a matéria prima), organizacionais (cultura e reputação) e financeiros (capacidade de investimento, financiamento, capital de giro, fluxo de caixa e lucro). Com o modelo VRIO, avaliou-se a organização desses recursos, em termos de estrutura organizacional, sistemas de controle e de remuneração adotados nas vinícolas investigadas.
Contribuições teóricas/metodológicas: Teoricamente, o estudo contribui ao identificar o potencial competitivo dos tipos de recursos, destacando quais são estratégicos.
Contribuições sociais/de gestão: Considerando os desafios que a cadeia produtiva de vinhos finos paranaense enfrenta para estabelecer sua competitividade e crescimento no cenário nacional, o estudo dos recursos pode auxiliar na consolidação dessa cadeia.
PENGAJARAN BAHASA INGGRIS DALAM KURIKULUM 2013: SUATU TINJAUAN DAN PERSPEKTIF
Authors: Setiawan Iwan
Published: March 2024

This study aimed at reviewing ELT and in use Curriculum 2013 and revealing teachers’ perspectives regarding its implementation. This was qualitative research using open-ended interview. Its participants were 5 teachers from 5 different schools, ranging from pilot to accompanying schools. The result shows that there are some differences between K-13 and KTSP in terms of curricular terminologies, the emphasis of students’ affective aspect, and learning approach; it is still difficult to create lesson plans of K-13 syllabi; overloaded aspects in students’ report cards to be assessed; confusing instructional models; lack of socialization and involvement of the teachers; K-13 uses a holistic approach; extra hours for character and religious education; autonomous learning; compact materials; reduction of English teaching hours; removal of English from elementary school; insufficient materials at primary levels; and so forth. Hence, this study concluded though Curriculum 2013 has already been well organized, yet it still needs more planning, socialization, involvement of many parties, and improvement of some factors should be more take into account by all elements of national education for the improvement of its implementation
EKSISTENSI RUMAH TAHFIDZ PARA SAHABAT TERHADAP PEMBERANTASAN BUTA AKSARA AL-QUR’AN DI RENGAS CONDONG MUARA BULIAN
Authors: Marzani Marzani , Yusup M. , Mahdayeni Mahdayeni , Maimunah Ira
Published: March 2024

The existence of Rumah Tahfidz Sahabat is the existence of an institution that can influence something where it is a place or facility for children to learn  and memorize the Qur'an. This research was conducted at the Tahfidz Para Companions House. As based on the initial Grand tour, the author sees that there are still many students who cannot read the Qur'an, so the teacher (ustadzah) must be able to provide learning how to read the Qur'an properly and correctly. The research objectives to be achieved in this study are: to determine the effect of the existence of Tahfidz Sahabat's House on the Eradication of Al-Qur'an Illiteracy in Rengas Condong, Muara Bulian District.
The method used by the researcher is a quantitative method. The population in this study were 50 students, 20 students for instrument testing and a sample of 30 students. This sample was obtained from 30 students using the Slovin formula. The hypothesis in this study is Ha: r > 0 or Ha: r 0. So there is a positive and significant influence between the influence of the existence of the Tahfidz House on eradicating illiteracy in the Qur'an.
This study provides an illustration that there is a positive and significant influence between the influence of the independent variable (the existence of the Tahfidz House) on the dependent variable (eradicating illiteracy of the Qur'an) of 74.8% while the remaining 25.5% is influenced or explained by other variables that not included in this research model. Although there are still students who are less able to read the Qur'an, at least the presence of this Tahfidz House can help in eradicating illiteracy of the Qur'an and can increase the motivation of students and the surrounding environment. This is evidenced by the completeness of student learning outcomes while at Tahfidz's house