bluuebunny/crossref_metadata_2025 huggingface dataset:
The prevalence of Brodie bite in untreated orthodontic patients in Nigeria
Authors: Ize-Iyamu Idia N. , Otaren Joseph N.
Published: September 2023

OBJECTIVE:

The Brodie bite (BRB) is a rare posterior crossbite affecting the transverse occlusal relationship with the palatal cusps of the upper molars, biting into the vestibule and outside the buccal cusps of the lower molar teeth. The BRB is a highly challenging orthodontic problem and is an extreme form of scissors bite. Patients with this problem present with facial deformity and inability to chew on the affected side. The problem is usually not identified until it becomes severe. This study aimed to identify the prevalence of BRB among untreated orthodontic patients in two geo-political zones in Nigeria.

METHODS:

A total of 1,041 untreated orthodontic patients who presented to two different orthodontic centres located in two geo-political zones (South/South-Benin City and North Central-Abuja, Nigeria) over a 3-year period were evaluated for the presence of BRB. The transverse dimension of the occlusion was examined for the presence of a crossbite or scissors bite. The molar teeth were used as the reference point for occlusion with Angle's classification of malocclusion. Four groups were identified, namely, teeth in occlusion (TIO) (Angle's Classes I, II or III malocclusion served as the control group), scissors or lingual crossbite (LCB), buccal crossbite (BCB) and BRB. A posterior crossbite was confirmed when the upper molar teeth were biting outside the buccal groove of the lower molar teeth either lingually or buccally. A BRB was identified when the palatal cusps of the upper molars were biting into the buccal vestibule of the lower jaw, with the deviation of the face to that side. Statistical analyses were performed using SPSS version 21; frequencies were determined for the variables, and cross-tabulations between the variables were established. P values < 0.05 were considered significant.

RESULTS:

The overall prevalence of BRB in this study was 0.6% (six patients). The values in the South/South (Benin City) were 997 untreated orthodontic patients, with a prevalence of 0.5% (five patients). The North Central (Abuja) zone had a total of 44 untreated orthodontic patients, with a prevalence of 2.3% (one patient). Unilateral BRB was seen in five patients (80%), and bilateral BRB was seen in one patient (20%). The condition was more prevalent among women (four patients, 80%) and on the right side (three patients, 60%). Angle's relationship in Classes I, II and III (TIO or control group) was seen in 911 patients (87.5%). The LCB and BCB groups comprised 39 (3.8%) and 85 patients (8.1%), respectively. Posterior crossbite was seen in 130 patients (12.5%).

CONCLUSION:

The prevalence of BRB in this study was found to be 0.6%, with the condition being more prevalent in women and on the right side.
An evaluation of dentofacial changes in Angle's class II division 1 patients using AdvanSync 2
Authors: Ponnamma Sanshavi , Reddy Goutham , Muddaiah Sunil , Somaiah Sanju , Shetty B K
Published: September 2023

OBJECTIVES:

The purpose of the study is as follows:

To evaluate the dental and skeletal changes of the AdvanSync 2 appliance.

To evaluate the soft tissue changes of the AdvanSync 2 appliance using photometric analysis.

METHODS:

The sample size consisted of 15 patients who reported to the Department of Orthodontics, seeking fixed orthodontic treatment. The effects of the AdvanSync 2 appliance were measured at two intervals.

RESULTS:

After the nine months, P values were observed to be less than 0.5, therefore statistically significant for parameters such as Sella-Nasion-Point A (SNA), Condylion-Point A (CO-A), University of Witwatersrand, Condylion-Gnathion (C0-Gn), point A-Nasion-Point B (ANB), Upper incisor-Point A (UI-A) (degree), LI-B (mm), Lower lip to Esthetic plane (LL-E plane), nasolabial angle, mentolabial angle, facial angle, and L lip to the chin. P values were however observed to be greater than 0.5, therefore statistically insignificant for parameters such as sella-Nasion-Point B (SNB), Condylion –gonion (C0-Go), UI A (mm), LI B (mm), UL-EPL, H LINE, Frankfurt mandibular plane (FMA), nose tip angle, nasofrontal angle, nasomental angle, upper lip angle, and U lip to the chin.

CONCLUSIONS:

AdvanSync 2 appliance brought about a change in Class II malocclusions through Co-Gn, Co-Go, ANB, FMA, UI-A (degree), UI A (linear) LI B (linear), Upper lip to Esthetic plane, LL-E plane, Holdaway LINE, nose tip angle, nasolabial angle, mentolabial angle, nasofrontal angle, nasomental angle, facial angle, upper lip angle, U lip to chin, L lip to the chin after nine months of appliance delivery.

MAIN POINTS:

AdvanSync 2 normalized class II by an increase in the length and body of the mandible.

AdvanSync 2 has a restraining effect on the growth of the maxilla.

AdvanSync 2 brings about positive soft tissue changes.

The major disadvantage is the proclination of the lower incisors.
MH-SETUP, combining Kesling wax-setup with indirect bonding and custom-made brackets for labial/lingual techniques to eliminate the finishing phase
Authors: Elkolaly Mohamed A. , Hasan Hasan Sabah
Published: September 2023

OBJECTIVE:

A novel technique, named the MH setup (MH is an abbreviation for the author's name), was developed to provide an accurate yet simplified method to produce custom-made brackets without bonding errors. This setup aimed to simplify the treatment and eliminate the finishing phase, so that the orthodontist was able to provide better care with less time and lower costs.

MATERIALS AND METHODS:

The setup was performed in two major steps: direct bonding on the cast followed by cutting and setting the teeth into precise positions using brackets. The first set of brackets, bonded directly onto casts, oriented the teeth by setting them ideally into wax rims with full control over first-, second-, and third-order bends. The fully engaged archwire used allowed for precise control over the arch symmetry and form. Setting teeth in wax allowed the clinician to refine the occlusion and correct any minor errors that arose during the initial bonding. The second set of brackets, mounted on the fully engaged archwire, featured custom-made composite bases. The transfer tray combined the benefits of its soft inner and hard outer layers, providing control over bonding and later ease of peeling from the brackets.

RESULTS:

The patient was satisfied with a full bonding procedure lasting 15 min that remained simple without unnecessary stress. The clinician was confident that the procedure allowed the precise positioning of brackets and simple bonding for all teeth in the arch, combined with the elimination of the finishing phase.

CONCLUSION:

The MH technique offered a simple, precise, and inexpensive improvement to the Kesling wax setup. The process allowed for precise bonding without errors or expensive armamentarium. The brackets were transformed into custom-made prescriptions and could be used with labial or lingual techniques. The method allowed for teeth addition, trimming, or overcorrection according to the clinician's preferences. The MH setup facilitated visualization of the treatment objectives with precise locations and the opportunity to revise the treatment plan or to discuss further options with the patient.
Prevalence of mesio-distal dilaceration in patients presenting for initial orthodontic care: A retrospective study
Authors: Qutieshat Abubaker , Al Harthy Nutayla , Javanmardi Shahab , Singh Gurdeep , Chopra Viresh , Aouididi Rayhana , Al Hanashi Omar , Al Arabi Abdulghani
Published: September 2023

OBJECTIVE:

To determine the prevalence of dilaceration in a sample of patients presenting for initial orthodontic care.

METHODS:

Examining radiographs from a random sample of orthopantomogram images was used to acquire the data. In all, 2,801 dental records were evaluated at Oman Dental College (ODC), Oman. A dental X-ray processing software was utilized to view the images. A tooth was classified as having a mesial/distal dilaceration if its long axis exhibited an angle of 90 degrees or greater. Dilacerated roots in the buccal/lingual direction were diagnosed by observing the appearance of a spherical opaque area with a dark shadow in its central region, projected by the apical foramen, which gave the root canal a “bull's-eye” appearance.

RESULTS:

Dilacerations were found in 17.32% of the records examined. The maxillary second molars (22.71%) were the most commonly affected, followed by the mandibular third molars and mandibular lateral incisors (21.90% and 17.23%, respectively). The central incisors and canines were the least affected, with dilaceration affecting less than 0.2% of the teeth. The mandible was found to have more dilacerations than the maxilla (53.78% and 46.22%, respectively). 61.03% of dilacerations occurred in molars, 43.12% of which occurred in third molars.

CONCLUSION:

Dilaceration is a notable dental anomaly that can affect any tooth, with some teeth being more affected than others. Dilaceration in maxillary second molars and mandibular lateral incisors is more common in the population of this study than in other populations reported in the literature. Recognizing the condition will allow for more effective orthodontic treatment.
Clinical and histological evaluation of the effect of magnesium oxide administration on relapse after orthodontic teeth movement (Rabbit Model Study)
Authors: Mohammed Roaa E. , Salih Al Qassar Sarmad S. , Taqa Ghada A.
Published: September 2023

OBJECTIVE:

This study aimed to evaluate the clinical and histological administration of magnesium oxide (MgO) supplementation on orthodontic relapse and bone remodeling.

MATERIALS AND METHODS:

Twenty male albino rabbits were classified into four groups (five animals for each as two control (positive and negative), plus two experimental (low dose 40 mg/kg) and (high dose 80 mg/kg)/b.w. daily). An orthodontic force was applied (40 gm) to the lower incisors using modified orthodontic appliance adapted on the lower central incisors. During the period of retention, MgO was given orally. Relapse was estimated after appliance removal. A digital Calliper was used to compete the space between incisors' mesial tips of rabbits at six successive time points (0, 3, 7, 10, 15, and 21 days). Histologically, osteoblast, osteoclast, and osteocyte account were assessed. Data analyses were performed by SPSS using ANOVA and Tukay HSD (P ≤ 0.05) for statistically significant differences between groups.

RESULTS:

The high dose group had a lower relapse rate than the low dose and control groups. Histologically, the high dose group had more osteoblasts and osteocytes than low dose and control groups. While osteoclasts were significantly lower than the control group in low and high dose groups.

CONCLUSIONS:

MgO supplementation during an orthodontic retention phase, particularly at a level of high dose, clinically decreased orthodontic relapse in a rabbit model. Histologically, MgO has a significant effect on alveolar bone after the orthodontic retention period.
Comparison of shear bond strength of bonded stainless steel brackets using three different light curing systems: An in vitro study
Authors: Soni Shashank , Shree Richa , Patri Vijeta , Jasoria Gaurav , Singh Sapana , Kushwah Ashish
Published: September 2023

OBJECTIVES:

To evaluate and compare the shear bond strength of stainless-steel brackets using three different light curing units

MATERIAL AND METHODS:

Using three LED curing units (3M ESPE Elipar, Ivoclar bluephase, and Woodpecker I LED light cure), 120 precoated metal brackets (Gemini series, 3M Unitek) were cured. The shear bond strength was recorded using a universal testing machine.

RESULT:

The shear strength of the bracket in different light-curing systems was examined with ANOVA test. The mean shear strength of group A, group B, and group C were 16.03 ± 14.30 MPA, 16.86 ± 11.89 MPA, and 20.51 ± 19.40, respectively. The result of the analysis shows that there is a major difference in shear bond strength of these three different light-curing systems with F value = 3.94 and P value 0.04

CONCLUSION:

We used three LED light-curing units with different intensities and manufacturing companies. The result showed that woodpecker I LED light had significantly highest mean SBS than the other two (Elipar LED curing light and 3M ESPE, Ivoclar bluephase).
Role of biodentine in endodontics: a bibliometric and scientometric analysis
Authors: Iuga Maria Mihaela , Romero-Carazas Rafael , Espada-Salgado Fernando , Oprea Bogdan , Stefanescu Stefan Vasile , Lavado-García Mayra
Published: September 2023

Objective. Vital Pulp therapy using Biodentine has advanced, introducing and allowing new procedures and treatments, hence medical education should focus on research and publication. The aim of the study was to perform a bibliometric and scientometric analysis of the literature on the role of biodentine in endodontics from 2013 to 2023. Methodology: A bibliometric and scientometric quantitative study formed the basis of the methodology. Scientific production indicators were generated from 87 documents selected from Scopus using English keywords ("Biodentine", "Endodontic"). Results: Since 2016, the number of papers published on this topic increased (69%), indicating a growing interest towards this material. Brazil is the country with the highest scientific  interest (19%), and the Universidade Estadual Paulista Júlio de Mesquita Filho with the most publications (n=9). The International Endodontic Journal received 344 citations, Tanomaru-Filho M. (n=6) being the most cited. Conclusion: It is concluded that the role of biodentine in endodontics has grown not only in production and authorship, but also in scope and medical research, incorporating these resources in various scenarios and clinical settings.
Transformation of Information Systems in the Tasikmalaya City Communication and Information Department
Authors: Herlina Dian , Harits Benyamin , Mulyana Yaya
Published: September 2023

Statistical data and information regarding government and regional development is a right of the community. But unfortunately, this has not been fully fulfilled in the community. This research then tries to look at the implementation of factors in managing information systems at the Tasikmalaya City Communication and Information Service. This research will be carried out using qualitative methods through case studies. The data used in this study came from observations and interviews. The results of this study then found that the management of information systems at the Tasikmalaya Office was still ineffective. Unprofessional executors and inadequate infrastructure have resulted in this. Several factors that can be useful in supporting information transformation at the Tasikmalaya City Service are data collection, data processing, data analysis and assessment, data presentation and dissemination, and documentation. Some of the inhibiting factors for this transformation are professional staff, infrastructure, and technology.
Impact of Social Support during Diagnosis and Treatment on Disease Progression in Young Patients with Breast Cancer: A Prospective Cohort Study
Authors: Kang Danbee , Park Seri , Kim Hyo Jung , Kim Seok Won , Lee Jeong Eon , Yu Jonghan , Lee Se Kyung , Kim Ji-Yeon , Nam Seok Jin , Cho Juhee , Park Yeon Hee
Published: September 2023

Purpose We evaluated the association between changes in social support after cancer treatment and recurrence-free survival (RFS) in such patients using a prospective cohort study.Materials and Methods Data were obtained from a prospective cohort study (NCT03131089) conducted at Samsung Medical Center (2013-2021). The primary outcome measure was RFS. Social support was measured using the social and family well-being (SFWB) domain of the Functional Assessment of Cancer Therapy-General. We calculated the changes in SFWB scores before and during treatment and the hazard ratio for RFS by comparing such changes.Results The mean±standard deviation (SD) age of the patients was 35±3.9 years, and 71.5% and 64.8% of the patients were married and had children, respectively. The mean±SD SFWB score at baseline was 20.5±5.0 out of 26. After cancer treatment, 35.9%, 10.3%, and 53.8% of the participants had increasing, unchanged, and decreasing SFWB scores, respectively. The decreasing SFWB score group had a higher risk of mortality or recurrence than the increasing group. Risk factors for the decreasing score were the presence of children during diagnosis.Conclusion In this cohort, changes in social support after treatment were associated with RFS in young patients with breast cancer. Health professionals should develop family interventions to help them receive proper social support.
Trends and Clinical Characteristics of Next-Generation Sequencing–Based Genetic Panel Tests: An Analysis of Korean Nationwide Claims Data
Authors: Jang Mi , Pak Hae Yong , Heo Ja Yoon , Lim Hyunsun , Choi Yoon-La , Shim Hyo Sup , Kim Eun Kyung
Published: September 2023

Purpose In the modern era of precision medicine, next-generation sequencing (NGS) is employed for a variety of clinical purposes. The aim of this study was to investigate the trends and clinical characteristics of NGS testing in South Korea.Materials and Methods This nationwide, population-based, retrospective cohort study examined National Health Insurance Service claims data from 2017 to 2021 for NGS and from 2008 to 2021 for gene-targeted anticancer drugs.Results Among the total 98,748 claims, there were 51,407 (52.1%) solid cancer panels, 30,173 (30.5%) hereditary disease panels, and 17,168 (17.4%) hematolymphoid cancer panels. The number of annual claims showed a persistent upward trend, exhibiting a 5.4-fold increase, from 5,436 in 2017 to 29,557 in 2021. In the solid cancer panel, colorectal cancer was the most common (19.2%), followed by lung cancer (18.8%). The annual claims for targeted cancer drugs have increased 25.7-fold, from 3,932 in 2008 to 101,211 in 2020. Drugs for the treatment of lung cancer accounted for 488,819 (71.9%) claims. The number of patients who received non-hereditary NGS testing has substantially increased, and among them, the count of patients prescribed targeted anticancer drugs consistently rose from 508 (13.9%) in 2017 to 2,245 (12.3%) in 2020.Conclusion This study highlights the rising nationwide demand for comprehensive genetic testing for disease diagnosis and treatment following NGS reimbursement by the National Health Insurance in South Korea, in addition to the need for greater utilization of targeted anticancer drugs.
Типичное рождение автоколебаний в блочной модели океанической циркуляции с турбулентными потоками
Authors: Davydov Alexey Alexandrovich , Zosimov Savva Orestievich
Published: September 2023

Для модели температурно-соленостной циркуляции в океане, доставляемой двумерной системой обыкновенных дифференциальных уравнений с разрывной функцией переноса, зависящей от параметров, описаны типичные бифуркации рождения нескольких автоколебательных режимов при изменении параметров функции переноса; в пространстве параметров найдены соответствующие бифуркационные диаграммы.
Анормальные траектории в субримановой $(2,3,5,8)$-задаче
Authors: Sachkov Yurii Leonidovich , Sachkova Elena Fedorovna
Published: September 2023

Анормальные траектории представляют особый интерес для субримановой геометрии, так как вблизи них субриманова метрика имеет наиболее сложные особенности. Важные открытые вопросы в субримановой геометрии - гладкость анормальных кратчайших и описание множества, заполненного анормальными траекториями, выходящими из фиксированной точки. Так, гипотеза Сарда в субримановой геометрии утверждает, что это множество имеет меру нуль. В данной работе рассматриваются это и другие родственные свойства указанного множества для левоинвариантной субримановой задачи с вектором роста $(2,3,5,8)$. Исследуется также глобальная и локальная оптимальность анормальных траекторий, получена их явная параметризация.
Robust Multiagent Reinforcement Learning toward Coordinated
Decision-Making of Automated Vehicles
Authors: He Xiangkun , Chen Hao , Lv Chen
Published: September 2023

Automated driving is essential for developing and deploying intelligent
transportation systems. However, unavoidable sensor noises or perception errors
may cause an automated vehicle to adopt suboptimal driving policies or even lead
to catastrophic failures. Additionally, the automated driving longitudinal and
lateral decision-making behaviors (e.g., driving speed and lane changing
decisions) are coupled, that is, when one of them is perturbed by unknown
external disturbances, it causes changes or even performance degradation in the
other. The presence of both challenges significantly curtails the potential of
automated driving. Here, to coordinate the longitudinal and lateral driving
decisions of an automated vehicle while ensuring policy robustness against
observational uncertainties, we propose a novel robust coordinated
decision-making technique via robust multiagent reinforcement learning.
Specifically, the automated driving longitudinal and lateral decisions under
observational perturbations are modeled as a constrained robust multiagent
Markov decision process. Meanwhile, a nonlinear constraint setting with
Kullback–Leibler divergence is developed to keep the variation of the driving
policy perturbed by stochastic perturbations within bounds. Additionally, a
robust multiagent policy optimization approach is proposed to approximate the
optimal robust coordinated driving policy. Finally, we evaluate the proposed
robust coordinated decision-making method in three highway scenarios with
different traffic densities. Quantitatively, in the absence of noises, the
proposed method achieves an approximate average enhancement of 25.58% in traffic
efficiency and 91.31% in safety compared to all baselines across the three
scenarios. In the presence of noises, our technique improves traffic efficiency
and safety by an approximate average of 30.81% and 81.02% compared to all
baselines in the three scenarios, respectively. The results demonstrate that the
proposed approach is capable of improving automated driving performance and
ensuring policy robustness against observational uncertainties.
Battery Thermal Management of Lithium Prismatic Cell Battery by Using
Different Coolants
Authors: Baviskar Shreyas , Chatterjee Dipankar , Jawale Kiran Chandrakant , Rammohan A.
Published: September 2023

Lithium (Li)-based batteries have wide applications in the everyday gadgets.
Li-based batteries have prominent usage in the automotive sector. All the major
OEMs for manufacturing hybrid electric vehicles (HEVs) and electric vehicles
(EVs) use only Li batteries and are still going to continue for the next
decades. However, during the operation of these batteries, they are susceptible
to environmental and battery factors. The amount of charge currently taken in or
out influences the internal resistance and temperature of the battery.
Therefore, the amount of heat generated by the Li-ion batteries during operation
is critical for designing a cost-effective and efficient thermal management
system (TMS) for HEVs and EVs. For that, the right cooling mechanism for a
lithium-ion (Li-ion) battery pack is to be chosen for the vehicles and
establishing optimal cooling conditions to keep the temperature within a safe
range of 15 to 35°C, which is critical to improving performance, safety, and
life of the battery. For a high-energy Li-ion battery module, this work provides
a comparison of air-type and liquid-type thermal management systems.
Computational fluid dynamics (CFD) simulations are used to investigate the
cooling performance of thermal management systems with different fluids. In this
study, the 12 V modules are made up of five prismatic pouch cells and initial
constant heat flux is provided for all the cases. The effect of different
coolants (i.e., air, water with ethylene glycol, and nano-coolant) at different
flow rates and compositions on the module’s thermal behavior are evaluated and
compared. Both air and ethylene glycol and water are given a flow rate of 0.5,
1.0, 1.5, and 2.0 m/s, whereas the nano-coolant is given a flow rate of 1.0 m/s.
As the nano-coolant flow rate is increased, the Li-ion temperature drops below
its optimum range, hence affecting its performance. The results of this research
are being put to use in the development of a more effective energy-saving
battery temperature management system and in the widespread adoption of
nano-coolant for Li batteries. It is observed that the nanofluid gave a superior
performance in terms of temperature reduction, that is, 5.04% and 2.97% more
efficient than air-cooling and water + ethylene glycol cooling.
The Politics of Pure Experience
Authors: Stone Richard
Published: September 2023

In this contribution, I shall attempt to clearly work out the political implications of Nishida Kitaro’s theory of pure experience in An Inquiry into the Good. This effort comes in response to the multitude of vastly different claims about the political meaning and dangers of Nishida’s early philosophy. Is it an implicit foundation for Japanese nationalism and the seeds of the controversial political philosophy he would work out later? Or is it a subtle attempt to critique the nationalist philosophy and educational policies surrounding Nishida while he was writing in the Meiji era? Or, perhaps most obviously, is this work unconnected with any and all political matters (including those that Nishida would face later on in his life)? In this paper, I shall argue that, although there is good reason to endorse any of these claims, ultimately a balanced assessment will find that Nishida’s early philosophy was indeed apolitical in nature, and that attempts to claim the contrary inevitably either go beyond textual evidence or miss key elements of his thought. Yet, as I shall further argue, being apolitical hardly means that Nishida’s work has no political consequences. Instead, for better or worse, the defining characteristic of Nishida’s early political philosophy is its capacity to allow readers to transcend such political issues.
A Humanist Reading of Wang Chong’s Defence of Divination
Authors: Cabural Mark Kevin
Published: September 2023

In this article, I present a new perspective on the thought of Wang Chong (王充, 27 CE – ca 97 CE) by drawing on Chung-Ying Cheng’s understanding of inclusive or intrinsic humanism. Specifically, I show how this type of humanism is reflected in Wang’s defence of divination and how his reinterpretation of the concepts of spontaneity (ziran 自然), endowment (ming 命), and natural disposition (xing 性) provide insights into the capabilities, concerns, and role of humans in the universe. Additionally, I describe the importance of ontocosmological humility in divination and inclusive humanism, then discuss how such a disposition or virtue figures in the modern scientific literature. While I offer a humanist reading of Wang’s defence of divination in this article, I also argue that ontocosmological humility can guide humans in making responsible actions and transforming themselves, other creatures, and the universe.
Expression of human cardiac-specific genes: a novel method for post-mortem interval estimation
Authors: Thakral Sahil , Purohit Purvi , Modi Anupama , Mishra Richa , Sinha Arvind , Setia Puneet
Published: September 2023

In legal medicine, the determination of post-mortem interval (PMI) is not only an important but also one of the most difficult aspects. Several methods are used to estimate PMI such as physicochemical, entomological, biochemical, metabolic, autolytic, and physical methods. These methods provide a wide range of PMI as they are affected by different factors. The approach behind the present study is to calculate an accurate PMI by using mRNA degradation and fold change expression (FCE) of cardiac-specific genes viz. N-terminal pro-B-type natriuretic peptide (NPPB) and cardiac troponin I (TNNI3). Seventeen cadaver heart tissues were analysed within a time frame of up to 12 hours from the time since death, at different time intervals at room temperature. Gene expression was determined and the data were analysed using the value of average delta Ct (ΔCt) value of the assessed gene and housekeeping gene. Delta delta Ct (ΔΔCt) method was used to calculate the FCE at the different 7-time groups. The FCE of TNNI3 was almost stable till 15 hours of PMI and then after 15 hours, expression shows a decrease up to 24 hours after death; whereas, NPPB shows that FCE was stable till 12 hours of PMI and then after 12 hours, expression shows a decrease up to 24 hours after death. The FCE of NPPB and TNNI3 was almost stable till 12 hours. Thus, the estimation of PMI by analysis of the FCE of cardiac-specific genes can be a new promising method in forensic medicine.
Review of the experiences of users of methaqualone and methaqualone derivatives. An analysis of online forums
Authors: Kuropka Patryk , Zawadzki Marcin , Szpot Paweł
Published: September 2023

The aim of this review article was to collect and analyze the available information on methaqualone and its derivatives reported by users in dedicated online forums. Methaqualone is a sedative-hypnotic drug that has been widely used for medical purposes in the past, but is now illegal in most countries due to its high abuse potential. The review collected information on doses, routes of administration, desirable and side effects of intoxication and other relevant aspects of the abuse of these compounds. The results of the study suggest that methaqualone and its derivatives continue to be used by some individuals despite their illicit status and potential health risks. The review, in the absence of other more reliable toxicological data, provides valuable insights from direct users on the use of these substances.
A Qualitative Study on the Process of Changing Multicultural Perceptions of College Students Participating in Role-playing Oriented Liberal Arts Classes
Authors: Mun Huijin , kIM Youngsoon , Sun Xiaohan
Published: September 2023

The purpose of this study is to explore the process of changing multicultural perceptions of college students who participated in liberal arts classes using role-playing, and to present multicultural education measures in higher education institutions. To this end, in-depth interviews were conducted with five college students who participated in liberal arts classes, and these were analyzed using phenomenological research methods. As a result, first, the participants stated that they were “indifferent” or had “uncomfortable feelings” about multiculturalism due to a lack of direct experience with migrants. Second, college students came to understand and respect others through the multicultural role-playing process. Third, research participants came to think about the attitudes they should have in a multicultural society in the future during their liberal arts class. This has led to changes in the perceptions of all people interacting in a multicultural society, regarding both their perceptions and attitudes.Based on these results, this study presented future multicultural education plans as follows. First, multicultural education should begin with content that can lead to “various levels of cultural curiosity” among the learners. This plays a role in relieving the indifferent or uncomfortable emotions that learners have. Second, before the role-playing activities, education that can help students better understand other cultures should be prioritized. This can reduce the difficulties students face when it comes to ‘cultural differences’ and ‘language barriers’ (communication) when learners write their role play scripts. Finally, multicultural education should be developed as a long-term curriculum rather than a one-off, and should be conducted to improve mutual cultural capabilities by engaging in “cultural exchange activities,” including the involvement of the migrants' language, culture, experiences, and values. This can help students internalize their necessary multicultural awareness on a long-term basis. It can also be a way for them to understand their foreign counterparts more deeply by providing opportunities for mutual cultural communication with them. Through this study, we looked at the process of changing college students' multicultural perception. It is hoped that this study will serve as useful basic data for the progress of multicultural education that can promote multicultural awareness for college students as well as for other learners.
ADHERENCIA TERAPÉUTICA EN DIABÉTICOS TIPO 2 DE UN CENTRO DE SALUD DE ECUADOR.
Authors: Miranda Aida , Gualán Sisa
Published: September 2023

Este estudio determinó la adherencia terapéutica en diabéticos Tipo 2 de un centro de salud de Ecuador. Se incluyeron 52 pacientes que aceptaron formar parte del estudio. Se elaboró un cuestionario estructurado por tres secciones para la recolección de datos, la primera indagó información sociodemográfica, la segunda contiene el test de Morisky-Green-Levine, y la tercera identificó factores que intervienen en la adherencia terapéutica. Todos los datos recolectados fueron representados mediante el Stadistical Program for Social Sciencies (SPSS) versión 25 y para valorar la influencia de la polimedicación en la adherencia terapéutica, se empleó la prueba de Chi-cuadrado con un nivel de significancia del 0,05. Como resultados se demostró que el 56,25 % de los pacientes no fueron adherentes al tratamiento, y que la adherencia no dependía de la cantidad de medicamentos consumidos por día. El factor que influyó en mayor porcentaje al cumplimiento terapéutico fue el convencimiento de la importancia de darle continuidad al tratamiento (96,87%). Finalmente, sereafirma la falta de adherencia terapéutica en pacientes con diabetes mellitus tipo 2, por lo que es importante crear estrategias a nivel sanitario que contribuyan a la promoción y prevención de este tipo de enfermedades.
SÍNTESIS DE NANOPARTÍCULAS DE MAGNETITA RECUBIERTAS DE QUITOSANO PARA LA ADSORCIÓN DE CROMO HEXAVALENTE.
Authors: González Myriam , Silva Jorge
Published: September 2023

En Ecuador muchos efluentes provenientes de la industria curtiembre presentan altos niveles de Cr (VI) generando gran impacto ambiental por la alta toxicidad del metal; una alternativa para remover este contaminante es mediante agentes adsorbentes como nanopartículas magnéticas. El objetivo de la presente investigación fue sintetizar nanopartículas de magnetita recubiertas de quitosano para la adsorción de cromo hexavalente. El quitosano se obtuvo a partir del exoesqueleto del camarón y las nanopartículas fueron sintetizadas por coprecipitación química y recubiertas con quitosano de manera In-situ. Se verificó la síntesis mediante espectroscopía infrarroja y microscopía electrónica de barrido. La capacidad de adsorción de cromo hexavalente se determinó a partir de experimentos de adsorción variando los parámetros termodinámicos, y la cuantificación del mismo se lo realizó utilizando espectroscopía UV-Visible. De tal manera que se obtuvieron nanopartículas con un diámetro promedio de 31,85 nm y el mayor porcentaje de adsorción fue del 99,70 %, con una capacidad máxima de adsorción de 294,12 mg/g a 60 °C. Demostrando que fue factible la adsorción de cromo hexavalente utilizando nanopartículas de magnetita recubiertas de quitosano con mejor capacidad de adsorción gracias al recubrimiento de quitosano.
Implementasi Program Pembangunan di Desa Kapur Kecamatan Sungai Raya Kabupaten Kubu Raya Kota Pontianak
Authors: Penny Penny , Ningrum Rani Wigati Ningrum , Nurwijayanto  , Tri Haryadi Didid Aditya , Prayoga Siska Fransiska
Published: September 2023

Desa yang berbatasan dengan pusat pertumbuhan ekonomi akan mempengaruhi pembangunan desa tersebut, baik fisik maupun non fisik, Apabila tidak dilaksanakan secara cermat, dapat menjadi kesenjangan ekonomi dan kesejahteraan bagi masyarakat setempat. Penelitian ini menggunakan metode kualitatif deskriptif. Pengumpulan data dengan observasi, dan wawancara mendalam (in-depth interview), informan drngan snowbal yang dipertimbangkan.  Hasil temuan pada penelitian , menunjukkan bahwa di Desa Kapur Kecamatan Sungai Raya kabupaten Kubu Raya Kota Pontianak  program pembangunan yang bersifat fisik seperti pembangunan jalan, drainase, jembatan, dan pembuatan barau, terintegrasi dengan program bersifat non fisik dalam hal ini pembinaan seperti pembinaan keterampilan pengolahan pakan/makanan dari ikan lele menjadi abon , program bidang kesehatan seperti pemberian makanan tambahan yang bergizi kepada ibu hamil serta pencegahan stunting, dan program pendidikan seperti pembinaan guru-guru, serta bimbingan di paud-paud desa guna langkah untuk melanjutkan pendidikan dasar dan seterusnya sehingga mereka bisa berkembang dengan baik
A Quantitative ABCD Analysis of Coffee Industry Stakeholders
Authors: V. A. Namreen Asif , Pai Ramesh
Published: September 2023

Purpose: The purpose of this research is to better understand how to utilize coffee growers and their organizations in the future as well as the Coffee Industry stakeholders' roles in the usage of agricultural machinery in the Modern Agriculture program of the coffee industry. In this study, stakeholders participating in the creation of contemporary agricultural programs are examined in terms of their involvement, influence, interests, and connection patterns. It is envisaged that this research would provide insight into how to more effectively oversee the implementation of contemporary coffee industry programs.
Design: The study uses a methodical strategy to examine the prior research, which includes looking up keywords, analyzing contributing elements, and applying the fundamental ABCD framework. The ABCD analysis establishes the pertinent score weights that are ascribed to each of the significant constituents under each parameter through the empirical data analysis of the agricultural stakeholders. The final step is to examine each element's total rating from a focus group in order to determine its overall evaluation.
Findings: The ABCD analysis technique can be used by all parties involved in the coffee industry, according to the study. According to the quantitative analysis of the ABCD framework, advantages to stakeholders in the coffee industry were given a high weighting and subsequently came benefits from focus group participation.
Originality: This article studies the numerous players in the coffee industry by heavily utilizing the ABCD analytical paradigm. Despite the fact that other ABCD analyses relating to various topics have been published, this study creates a space for original research in the area of coffee industry stakeholders by identifying the key elements of each problem.
Type of Paper: Empirical Analysis.
The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study
Authors: Huang Guoxin , Qian Da , Liu Ying , Qu Gaojing , Qian Yuanyuan , Pei Bin
Published: September 2023

Introduction

The aim of the study was to examine the association between frailty and osteoarthritis.

Material and methods

We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomization (MR) study was used to explore the causal relationship between the two.

Results

In the cross-sectional study, logistic regression analysis showed that odds ratio (OR) (95% CI) value was 1.07 (1.05, 1.08). In the MR study, the inverse-variance weighting (IVW) results showed OR (95% CI) value of 1.69 (1.01–2.83).

Conclusions

There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis.
Analisis Penyebab Tindakan Bullying dengan Pendidikan Karakter Cinta Damai di Sekolah Dasar
Authors: Dewantari Sabbihisma Maydita , Humairah Humairah , Kharisma Ahmad Ipmawan
Published: September 2023

Bullying merupakan tindak kekerasan yang diperbuat seseorang kepada orang lain bertujuan untuk menyakiti orang tersebut baik fisik maupun non fisik dan dilakukan secara berulang-ulang. Pendidikan karakter telah diterapkan di lembaga pendidikan sejak tahun 2010. Penelitian ini memiliki tujuan untuk mengetahui faktor-faktor penyebab tindakan bullying terjadi dengan pendidikan karakter di sekolah dasar. Pada penelitian kali ini menggunakan jenis penelitian kualitatif deskriptif dan bertempat di 2 sekolah dasar di Lamongan. Subjek dalam penelitian ini adalah siswa kelas 5, guru kelas 5, orang tua siswa kelas 5, dan juga kepala sekolah dari SD yang diteliti. Penelitian ini menggunakan teknik pengumpulan data observasi, angket, dan wawancara sedangkan teknik analisis data yang digunakan adalah model interaktif Miles, Huberman, & Saldana. Untuk mengecek keabsahan data yang diambil, digunakanlah teknik triangulasi metode. Hasil yang diperoleh pada penelitian ini adalah 39,43% siswa mengalami tindakan bullying verbal, 8,86% bullying fisik, dan 5,71% mengalami bullying relasional. Faktor penyebab seseorang melakukan tindakan bullying didapatkan dari faktor keluarga, pola asuh, dan lingkungan pergaulan. Pendidikan karakter memiliki keterkaitan dengan tindakan bullying. Melalui pendidikan karakter siswa mampu mengetahui hal yang baik dan kurang baik.
Timing of adjuvant chemoradiation for pancreatic cancer with positive surgical margins
Authors: Alkış Hilal , Arıkan Rukiye , Kornienko Aleksei , Gündüz Hatice Kübra , Adlı Mustafa
Published: September 2023

Aims: Impact of adjuvant chemoradiation timing on the outcome of pancreatic cancer patients with positive surgical margins is unknown. The aim of this study was to evaluate the effect of adjuvant chemoradiation timing for margin positive pancreatic cancer patients.
Methods: A total of 36 pancreatic adenocarcinoma patients with positive surgical margins and received adjuvant chemoradiation were included in the study. The median radiation dose was 50.4 Gy in 28 fractions. The primary study variable was the timing of chemoradiation, grouped as immediate (after ? 1 cycle of chemotherapy) and delayed (after two or more cycles of chemotherapy) chemoradiation. Gemcitabine (n = 16) and capecitabine (n = 20) were chemotherapy regimens administered with radiation.
Results: Median follow-up time was 23.7 months. Thirteen patients (36%) received immediate and 23 (64%) received delayed chemoradiation. For immediate and delayed treatment groups, median overall survival was 13.5 and 42.5 months, and disease-free survival was 6.4 and 18.8 months, respectively. Disease-free survival and overall survival were better with delayed chemoradiation (p = 0.02). However, the two groups did not significantly differ in locoregional control (p = 0.96).
Conclusion: Delaying chemoradiation until completion of systemic therapy improves disease-free survival and overall survival without any difference in locoregional failure compared to early chemoradiation in pancreatic cancer patients with positive surgical margins.
Frequency of night eating syndrome and its relationship with impulsivity in bariatric surgery candidates
Authors: Özcanlı Çay Özlem , Kemer Aycan Özlem
Published: September 2023

Aims: Eating attitude disorders are more common in obese individuals compared to the normal population and cause resistance to treatment. In our study, it is aimed to determine the frequency of night eating syndrome, which is an eating disorder, and to reveal its relationship with impulsivity, which is a personality trait, in bariatric surgery candidates with severe obesity .
Methods: Between May 2022 and December 2022, 93 patients aged 18-65 years who were planned for bariatric surgery were applied to Balıkesir University Health Practice and Research Hospital General Surgery outpatient clinic, Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD), Barratt impulsivity scale (BIS-11), Night Eating Questionnaire (ADL) were applied.
Results: 69 (74.2%) of the participants were women. There was no significant difference between genders in terms of ADL
scores (p=0.683). h Night eating syndrome was detected in one third of the patients. (N=31). Barratt -not planning and total
scale scores of patients with an ADL score above 25 were found to be higher than those with an ADL score of 25 and below
(p=0.010, p=0.044, respectively).
Conclusion: Considering that night eating syndrome is associated with one third of obesity and it is associated with impulsivity, addressing the impulsivity of individuals with overeating in cognitive behavioral therapy before the operation will contribute to the success of the treatment.
Anomalous Origin of Left Coronary Artery from The Pulmonary Artery of Left Main Coronary Artery (ALCAPA) In A Pediatric Patient: A Rare Case Report
Authors: Widyaningsih Made Ayu , Gunawijaya Eka , Yanti Ni Putu Veny Kartika
Published: September 2023

Background: The anomalous origin of the left coronary artery (LCA) from the pulmonary artery (ALCAPA) is a rare congenital anomaly due to abnormal division of the conotruncus into the aorta and pulmonary artery or persistence of the pulmonary bud with involution of the aortic bud that forms the origin of the coronary artery on embryogenesis. Only a small portion of cases survive more than two months of age. The survived cases can appear as asymptomatic, symptomatic, sudden cardiac death of adulthood ALCAPA. Case Description: We present an 8-year-old boy with symptomatic adulthood type ALCAPA. Preliminary chest x-ray examination found cardiomegaly. Unspecific findings were found on Echocardiography including fistula right coronary artery (RCA) and left coronary artery (LCA), with mitral regurgitation, moderate tricuspid regurgitation, and cardiomyopathy. Catheterization confirmed the left coronary artery from the pulmonary artery (ALCAPA) of the left main coronary artery (LMCA) origin. Additional Cardiac computed tomography angiography (CTA) demonstrated the LM originates from the pulmonary trunk accompanied by the presence of collaterals between the RCA and LAD and dilatation and turbulence of the RCA. Conclusion: Early diagnosis and prompt surgical intervention can give excellent results and lead to gradual recovery.