bluuebunny/crossref_metadata_2025 huggingface dataset:
KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS
Authors: Apara Akintomide , Galvao Joana , Wang Yan , Blackmore Murray , Trillo Allison , Iwao Keiichiro , Brown Dale P. , Fernandes Kimberly A. , Huang Abigail , Nguyen Tu , Ashouri Masoumeh , Zhang Xiong , Shaw Peter X. , Kunzevitzky Noelia J. , Moore Darcie L. , Libby Richard T. , Goldberg Jeffrey L.
Published: September 2017

Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs regulate axon growth in CNS neurons including retinal ganglion cells (RGCs). Here, we found that knock-down of KLF9, an axon growth suppressor that is normally upregulated 250-fold in RGC development, promotes long-distance optic nerve regeneration in adult rats of both sexes. We identified a novel binding partner, MAPK10/JNK3 kinase, and found that JNK3 (c-Jun N-terminal kinase 3) is critical for KLF9's axon-growth-suppressive activity. Interfering with a JNK3-binding domain or mutating two newly discovered serine phosphorylation acceptor sites, Ser106 and Ser110, effectively abolished KLF9's neurite growth suppressionin vitroand promoted axon regenerationin vivo. These findings demonstrate a novel, physiologic role for the interaction of KLF9 and JNK3 in regenerative failure in the optic nerve and suggest new therapeutic strategies to promote axon regeneration in the adult CNS.

SIGNIFICANCE STATEMENTInjured CNS nerves fail to regenerate spontaneously. Promoting intrinsic axon growth capacity has been a major challenge in the field. Here, we demonstrate that knocking down Krüppel-like transcription factor 9 (KLF9) via shRNA promotes long-distance axon regeneration after optic nerve injury and uncover a novel and important KLF9–JNK3 interaction that contributes to axon growth suppressionin vitroand regenerative failurein vivo. These studies suggest potential therapeutic approaches to promote axon regeneration in injury and other degenerative diseases in the adult CNS.
Sodium Channel β2 Subunits Prevent Action Potential Propagation Failures at Axonal Branch Points
Authors: Cho In Ha , Panzera Lauren C. , Chin Morven , Hoppa Michael B.
Published: September 2017

Neurotransmitter release depends on voltage-gated Na+channels (Navs) to propagate an action potential (AP) successfully from the axon hillock to a synaptic terminal. Unmyelinated sections of axon are very diverse structures encompassing branch points and numerous presynaptic terminals with undefined molecular partners of Na+channels. Using optical recordings of Ca2+and membrane voltage, we demonstrate here that Na+channel β2 subunits (Navβ2s) are required to prevent AP propagation failures across the axonal arborization of cultured rat hippocampal neurons (mixed male and female). When Navβ2 expression was reduced, we identified two specific phenotypes: (1) membrane excitability and AP-evoked Ca2+entry were impaired at synapses and (2) AP propagation was severely compromised with >40% of axonal branches no longer responding to AP-stimulation. We went on to show that a great deal of electrical signaling heterogeneity exists in AP waveforms across the axonal arborization independent of axon morphology. Therefore, Navβ2 is a critical regulator of axonal excitability and synaptic function in unmyelinated axons.

SIGNIFICANCE STATEMENTVoltage-gated Ca2+channels are fulcrums of neurotransmission that convert electrical inputs into chemical outputs in the form of vesicle fusion at synaptic terminals. However, the role of the electrical signal, the presynaptic action potential (AP), in modulating synaptic transmission is less clear. What is the fidelity of a propagating AP waveform in the axon and what molecules shape it throughout the axonal arborization? Our work identifies several new features of AP propagation in unmyelinated axons: (1) branches of a single axonal arborization have variable AP waveforms independent of morphology, (2) Na+channel β2 subunits modulate AP-evoked Ca2+-influx, and (3) β2 subunits maintain successful AP propagation across the axonal arbor. These findings are relevant to understanding the flow of excitation in the brain.
Odorant Receptor Sensitivity Modulation inDrosophila
Authors: Guo Hao , Kunwar Kishor , Smith Dean
Published: September 2017

The ability to modulate sensitivity in sensory systems is essential for useful information to be extracted from fluctuating stimuli in a wide range of background conditions. The mechanisms underlying sensitivity regulation in insect primary olfactory neurons are poorly understood. Here we reveal that dephosphorylation of OrcoS289that occurs upon prolonged odor exposure is a mechanism underlying reduction in odorant sensitivity inDrosophilaprimary olfactory neurons in both sexes.OrcoS289Amutants, unable to phosphorylate this position, have low intrinsic odorant sensitivity that is independent of altered expression or localization. A phosphomimetic allele,OrcoS289D, has enhanced odorant sensitivity compared with wild-type controls. To explore the functional ramifications of this phosphorylationin vivo, we generated phospho-specific antiserum to OrcoS289and show that phosphorylation at this residue is dynamically regulated by odorant exposure with concomitant modulation of odorant sensitivity. OrcoS289is phosphorylated in the sensitized state, and odorant exposure triggers dephosphorylation and desensitization without altering receptor localization. We further show that dephosphorylation of OrcoS289is triggered by neuronal activity, and not conformational changes in the receptor occurring upon ligand binding. Mutant flies unable to regulate Orco function through phosphorylation at S289 are defective for odor-guided behavior. These findings provide insight into the mechanisms underlying regulation of insect odorant receptorsin vivo.

SIGNIFICANCE STATEMENTWe have uncovered a mechanism underlying olfactory receptor sensitivity regulation inDrosophila. The phosphorylation state of OrcoS289is altered in an odorant-dependent manner and changes in phosphorylation affect receptor sensitivity without changing subcellular localization. We show that neuronal activity triggers the phosphorylation changes and that this phenomenon is important for odorant-guided behaviors inDrosophila. This phosphorylation site is conserved in other insects, including mosquitoes, indicating this mechanism may be a target for manipulation of insect behaviors in the future.
Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells
Authors: Kot Alexander , Zhong Zhendong A , Zhang Hongliang , Lay Yu-An Evan , Lane Nancy E , Yao Wei
Published: September 2017

Increasing peak bone mass is a promising strategy to prevent osteoporosis. A mouse model of global progesterone receptor (PR) ablation showed increased bone mass through a sex-dependent mechanism. Cre-Lox recombination was used to generate a mouse model of osteoprogenitor-specific PR inactivation, which recapitulated the high bone mass phenotype seen in the PR global knockout mouse mode. In this work, we employed RNA sequencing analysis to evaluate sex-independent and sex-dependent differences in gene transcription of osteoprogenitors of wild-type and PR conditional knockout mice. PR deletion caused marked sex hormone-dependent changes in gene transcription in male mice as compared to wild-type controls. These transcriptional differences revealed dysregulation in pathways involving immunomodulation, osteoclasts, bone anabolism, extracellular matrix interaction and matrix interaction. These results identified many potential mechanisms that may explain our observed high bone mass phenotype with sex differences when PR was selectively deleted in the MSCs.
Mendelism: New Insights from Gregor Mendel’s Lectures in Brno
Authors: Zhang Hui , Chen Wen , Sun Kun
Published: September 2017

After dissolving misinterpretation and prejudice of the newspaper report of Mendel’s lectures, we found the lecture content can be recovered...

Interpretation of Gregor Mendel’s work has previously been based on study of his published paper “Experiments in Plant Hybridization.” In contrast, the lectures that he gave preceding publication of this work have been largely neglected for more than 150 years. Here, we report on and interpret the content of Mendel’s previous two lectures, as they were reported in a local newspaper. We comprehensively reference both the text of his paper and the historical background of his experiments. Our analysis shows that while Mendel had inherited the traditional research program on interspecific hybridization in plants, he introduced the novel method of ratio analysis for representing the variation of unit-characters among offspring of hybrids. His aim was to characterize and explain the developmental features of the distributional pattern of unit-characters in two series of hybrid experiments, using self-crosses and backcrosses with parents. In doing so, he not only answered the question of what the unit-characters were and the nature of their hierarchical classification, but also successfully inferred the numerical principle of unit-character transmission from generation to generation. He also established the nature of the composition and behaviors of reproductive cells from one generation to the next. Here we highlight the evidence from Mendel’s lectures, clearly announcing that he had discovered the general law of cross-generation transmission of unit-characters through reproductive cells containing unit-factors. The recovered content of these previous lectures more accurately describes the work he performed with his garden peas than his published paper and shows how he first presented it in Brno. It is thus an invaluable resource for understanding the origin of the science of genetics.
Gastric Microbiota: Tracing the Culprit
Authors: Petra Cristian Vasile , Rus Aronel , Dumitrașcu Dan Lucian
Published: September 2017

The gastric environment has been long time considered bacteria-free, but the discovery of Helicobacter pylori (H. pylori) in 1982 superseded this conception. Over the last decades new diagnostic methods have been developed, starting with culture-dependent and advancing to culture-independent ones. These modern techniques provide new insight into the composition and influence of this ecosystem on the entire gastrointestinal tract. H. pylori is no longer considered the only microorganism in the stomach, other non-H. pylori microbial species may populate the same environment and exercise their role. Current knowledge suggests possible links of these bacteria with gastroduodenal diseases, such as peptic ulcer and gastric cancer but most of them need further scientific evidence. This review summarizes current information on these complex interrelations between gastric microbial communities and host in health and disease.
Molecular Biomarkers as Predictors for Biliary Complications Following Liver Transplantation. A Prospective Study
Authors: Dorobantu Bogdan , Popescu Irinel , Dima Simona , Nastase Anca , Iacob Speranta
Published: September 2017

Background: The biliary complications (BC) have been always considered the „Achilles’ heel” of liver transplantation (LT), being one of the leading causes of postoperative morbidity. Aim: To analyse predictors of BC, by monitoring in the peripheral blood the biomarkers involved in the inflammation and hepatic fibrosis, such as the matrix metalloproteinases (MMP 2, 9) and their tissue inhibitors (TIMP1), the interleukins (IL 2, 8), alfa-TNF, the endothelins and their receptors.Methods: Thirty LT patients were followed-up prospectively for 5 years. The mRNA for the following biomarkers was quantified in the peripheral blood by qRTPCR and protein expression investigated by ELISA: MMP 2, 9, TIMP1, IL 2, IL 8, TNF-alfa, and endothelins and their receptors.Results: Five patients developed anastomotic stenosis (AS). There was no difference regarding mRNA levels for all studied genes between AS and non-AS patients. Two cytokines were significantly different: pre-LT TNF alpha was higher in the non-AS group and post-LT endothelin-1 at day 7 and month 3 were higher in the AS group. There was a trend for lower levels of serum cytokines for patients without AS compared to patients with AS.Conclusion: BC play an important role in the patients‘ postoperative morbidity and molecular biomarkers prediction should improve their early recognition and treatment..Abbreviations: ALT: alanine aminotransferase; AS: anastomotic stenosis; AST: aspartate aminotransferase; BC: Biliary complications ; HBV: hepatitis B virus; HCV: hepatitis C virus; HDV: hepatitis D virus; HSC: hepatic stellate cells; IL: interleukin; IR: ischemia reperfusion; LT: liver transplantation ; MMP: matrix metalloproteinases; TIMP: metalloproteinases tissue inhibitor; TGF: tumor growth factor; TNF: tumor necrosis factor.
Identifying a Mucinous Neoplasm Utilizing Confocal Laser Endomicroscopy: Branch-Duct Gastric Type Intraductal Papillary Mucinous Neoplasm
Authors: Kamboj Amrit K. , Modi Rohan M. , Conwell Darwin L. , Krishna Somashekar G.
Published: September 2017

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MÃE, Valter Hugo. Homens imprudentemente poéticos. Porto: Porto Editora, 2016. 216 p.
Authors: Topa Francisco
Published: September 2017

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ANALYSIS OF GROWTH OF LALAWAK Barbonymus balleroides (VALENCIENNES, 1842) IN THREE CULTURE METHODS
Authors: Radona Deni , Prakoso Vitas Atmadi , Kusmini Irin Iriana
Published: September 2017

In fish culture, optimal growth could be influenced by various culture methods. Aim of the study was to evaluate the productivity of Barbonymus balleroides, lalawak in floating net cages, concrete ponds, and earthen ponds. Cultivation was designed with the circulation water system. Experiment was conducted using completely randomized design with three treatments and three replications for each treatment. The experimental fish, sized of 4.20 ± 0.64 cm SL and weight of 2.14 ± 0.99 g, were obtained from induced breeding. The stocking density used was 20 individuals/m3. Fish were fed 3% of total weight two times every day using commercial pellet with 35% protein content for 90 day. The result showed that lalawak reared in earthen pond was no significant difference on length, weight, and biomass compared with that one in concrete pond (P>0.05), but significantly different (P<0.05) with floating net cages. There were no different (P>0.05) among the three different culture systems for survival rate and FCR. Lalawak reared on earthen pond system supported with optimal water quality could increase productivity value.
PERFORMANCE OF CULTURED White-leg Shrimp IN RICA Probiotic Application METHOD in PONDS AERATED WITH SUPERCHARGE BLOWER
Authors: Susianingsih Endang , Kurniawan Koko , Atmomarsono Muharijadi
Published: September 2017

Several ways have been done to encounter shrimp disease affecting cultured shrimp in Indonesian ponds in the last two decades. This research was aimed to find out the effect of different application of probiotic RICA4, RICA5, and RICA3 method on survival rate and production of white-leg shrimp (Litopenaeus vannamei) cultured in ponds aerated with supercharge blower. RICA probiotics are bacteria probiotics produced by the Research and Development Institute for Coastal Aquaculture, originally isolated from seaweed and sea sediment. This experiment was carried out in completely randomized design using nine 250-m2 experimental ponds stocked with 15 shrimp fries/m2. There were three treatments namely: A=alternate use of three probiotics RICA4, RICA5, and RICA3; B=combination use of three probiotics RICA4, RICA5, and RICA3; and C=control (without probiotic), each treatment with three replications and cultured with supercharge blower. Variables observed in this study were survival rate and production of the shrimp calculated at the end of experiment, total vibrio count (TBV) and total plate count of common bacteria (TPC) of the pond waters and sediments monitored every two weeks. The results showed that application of probiotic RICA4, RICA5, and RICA3 applied either in alteration or in combination significantly increased survival rate (P<0.05) but not on production (P>0.05) of the white-leg shrimp. TBV/TPC ratio in the control pond waters after 10-weeks culture (over than 10%) was relatively dangerous for the cultured white-leg shrimp. This shows that application of probiotic could prevent the growth of Vibrio spp in the cultured shrimp pond water.
Analisis Supposed Capable Fault Sebagai Data Dukung Rencana Tapak PLTN Bojonegara, Propinsi Banten
Authors: Raharjo Purnomo , Mellawati June , SBS Yarianto
Published: September 2017

ANALISIS SUPPOSED CAPABLE FAULT SEBAGAI DATA DUKUNG RENCANA TAPAK PLTN BOJONEGARA, PROPINSI BANTEN. Lokasi sesar dan daerah beradius 150 km dari garis sesar atau zona sesar merupakan daerah yang tertolak atau dihindari dalam pemilihan daerah tapak interes PLTN. Tujuan penelitian adalah untuk mengidentifikasi keberadaan sesar permukaan atau sesar kapabel di lokasi tapak PLTN. Metodologi penelitian meliputi interpretasistruktur sesar, analisis seismik refleksi di darat dan laut, analisis seismotektonik, dan menentukan daerah terbebas bahaya pensesaran permukaan. Wilayah studi regional, yaitu radius 150 km dari daerah interes, mencakup Propinsi Banten, DKI Jakarta, Jawa Barat, dan Sumatera Selatan (sebagian Lampung). Hasil interpretasi citra landsat, struktur sesar memperlihatkan pola yang berarah timur laut - barat daya yang diwakili oleh Sesar Cimandiri, barat laut – tenggara yang diwakili oleh Sesar Citandui, Sesar Baribis, Sesar Tangkuban Perahu. Pola sesar yang berarah timur laut – barat daya diperkirakan merupakan pola struktur mendatar sinistral (left lateral faults), dan pola sesar yang berarah barat laut – tenggara merupakan sesar mendatar dekstral (right lateral faults). Berdasarkan data seismik di darat, sesar yang menembus sampai Formasi Cisubuh dikategorikan sebagai Supposed Capable Fault. Analisis sekuen stratigrafi seismik laut dikorelasikan dengan satuan umur pengendapan pada Zaman Plistosen, dimana terbagi dalam QT (Batas Tersier dan Plistosen Awal), Q1 (Batas Plistosen Awal dan Plistosen Tengah), dan Q2 (Batas Plistosen Tengah dan Plistosen Akhir), suppose capable fault menembus sekuen Plistosen awal hingga akhir. Hasil analisis seismotektonik terdapat sesar kapabel diperkirakan (supposed capable fault).Keywords: Sesar Permukaan, Tapak PLTN, Bojonegara
Penentuan Kedalaman Batuan Dasar Menggunakan Microtremor Array Di Tapak RDE Serpong
Authors: Suntoko Hadi , Sriyana Sriyana
Published: September 2017

Kawasan PUSPIPTEK Serpong merupakan kawasan teknologi tinggi sesuai Rencana Tata Ruang Wilayah (RTRW) Kota Tangerang Selatan, 2011-2031, sehingga kawasan ini ditetapkan sebagai tapak Reaktor Daya Eksperimental (RDE). Untuk menjamin keselamatan, evaluasi tapak dari berbagai aspek harus dilakukan, salah satunya adalah aspek kegempaan. Merujuk Perka BAPETEN Nomor 8 tahun 2013, evaluasi tapak perlu mengkaji kondisi geologi bawah permukaan. Tujuan dari penelitian ini adalah untuk mendapatkan informasi kondisi geologi bawah permukaan khususnya kedalaman batuan dasar di area tapak RDE. Metode yang digunakan dalam penelitian ini adalah microtremor array (MA). Hasil yang diperoleh menunjukkan bahwa tapak RDE memiliki batuan dasar berupa batuan dari Formasi Bojongmanik pada kedalaman 391 meter dari permukaan tanah.
Bouguer Density Analysis using Nettleton Method at Banten NPP Site
Authors: Yuliastuti Yuliastuti , Suntoko Hadi , Budi Susilo Yarianto Sugeng
Published: September 2017

BOUGUER DENSITY ANALYSIS USING NETTLETON METHOD AT BANTEN NPP SITE. Sub-surface information become crucial in determining a feasible NPP site that safe from external hazards. Gravity survey which result as density information, is essential to understand the sub-surface structure. Nevertheless, overcorrected or under  corrected will lead to a false interpretation. Therefore, density correction in term of near-surface average density or Bouguer density is necessary to be calculated. The objective of this paper is to estimate and analyze Bouguer density using Nettleton method at Banten NPP Site. Methodology used in this paper is Nettleton method that applied in three different slices (A-B, A-C and A-D) with density assumption range between 1700  and 3300 kg/m3. Nettleton method is based on minimum correlation between gravity anomaly and topography to determine density correction. The result shows that slice A-B which covers rough topography difference, Nettleton method failed. While using the other two slices, Nettleton method yield with a different density value, 2700 kg/m3 for A-C and 2300 kg/m3 for A-D. A-C provides the lowest correlation value which represents the Upper Banten tuff and Gede Mt. volcanic rocks in accordance with Quartenary rocks exist in the studied area.
Getting started on your project v1
Authors: L Hurwitz Bonnie
Published: September 2017

Today, we are going to get you set up for your class project. You will need a class directory for putting all of your files. Also, you will need to download the data for your project (see the list of SRR numbers in D2L).
Phytoplankton sinking rates through time-resolved fluorescence plate spectroscopy v1
Authors: C. Bannon Catherine , A. Campbell Douglas
Published: September 2017

We established a method for parallel, large scale analysis of multiple phytoplankton sinking rates through top-view monitoring of chlorophyll a fluorescence in microtitre well plates. We verified the method through experimental analysis of known factors that influence sinking rates, including exponential versus stationary growth phase in species of different cell sizes; Thalassiosira pseudonana CCMP1335, chain-forming Skeletonema marinoi RO5A and Coscinodiscus radiatus CCMP312. We fit decay curves to an algebraic transform of the decrease in fluorescence signal as cells sank away from the fluorometer detector, and then used minimal mechanistic assumptions to extract a sinking rate (m d-1) using an RStudio script, SinkWORX.
Antiguidade Tardia: conceitos e história a partir de uma perspectiva brasileira
Authors: Ramalho Jefferson
Published: September 2017

Resenha de: FUNARI, Pedro Paulo A.; CARLAN, Cláudio Umpierre. Antiguidade Tardia e o fim do Império Romano no Ocidente. São Paulo: Fonte Editorial, 2016, 116p.
A poesia na biblioteca escolar: análise das marcas da escrita feminina no acervo do PNBE 2013
Authors: Ferreira Eliane Aparecida Galvão Ribeiro , Stringuetti Lucas Mateus Vieira de Godoy
Published: September 2017

Este texto tem por objetivo refletir sobre o discurso feminino nas obras literárias poéticas que compõem o acervo de 2013 do PNBE – Programa Nacional Biblioteca da Escola, destinado às séries finais do Ensino Fundamental. Mais especificamente, pretende-se detectar como as escritoras representam sua enunciação visando ao público jovem e averiguar se tais obras possuem potencialidades estéticas e emancipatórias para seu leitor, ampliando seus horizontes de expectativas. Para a consecução deste objetivo, a partir do aporte teórico da Estética da Recepção, as seguintes obras são analisadas: Adolescente Poesia (2010), de Sylvia Orthof, Estação dos Bichos (2011), de Alice Ruiz S. e Camila Jabur, e O mar e os sonhos (2011), escrito por Roseana Murray.
O estágio não obrigatório no contexto da formação inicial do Pedagogo
Authors: Leandro de Paiva Maria Cristina , Costa Leide Dayana Pereira de Freitas
Published: September 2017

Este artigo se propõe a desvelar o estágio não obrigatório, em contraponto ao estágio obrigatório e à regulamentação legal que o ampara, no sentido de apontar o cenário complexo em que está se efetivando nas políticas públicas para o atendimento às crianças da educação infantil. Busca-se, ainda, analisar de que maneira o estágio não obrigatório se faz presente no âmbito das pesquisas que são realizadas na área da educação no Brasil. Compreende-se, que em sendo o estágio não obrigatório uma das possibilidades de percurso formativo inicial docente, esse se configura enquanto uma das vias de ingresso à prática de muitos professores, embora se verifique uma insipiente discussão dessa temática, seja na legislação vigente, seja no campo das pesquisas em educação. Expande-se um campo de trabalho à margem das mínimas condições necessárias à almejada profissionalização docente e à qualidade social referenciada na educação das crianças pequenas.
O processo produtivo de construção “natureza”: análise de um vídeo publicitário dos produtos Natura Ekos
Authors: Martins Thaís Presa , Souza Nádia Geisa Silveira de
Published: September 2017

Hoje, ao integrar a noção de “natureza”, o conceito de biodiversidade apresenta caráter estratégico, pois alia aspectos que interessam a diferentes instâncias: sociais, políticas, econômicas, científicas e ambientalistas. A publicidade vale-se de discursos sobre a biodiversidade como artifícios para vender, ensinando “verdades” sobre a “natureza”. Analisou-se como e de que lugar um vídeo de Natura Ekos fala sobre a biodiversidade amazônica, para promover o sistema capitalista sustentável. O estudo pautou-se pelos Estudos Culturais, em suas vertentes pós-estruturalistas. A campanha reforça a identificação dos consumidores com a Natura, ensinando como devem agir em relação à “natureza” e por qual sistema produtivo devem optar ao consumir.
Sustentabilidade Ambiental nas Redes Sociais: reflexos de uma atividade interdisciplinar
Authors: Bedin Everton , Del Pino José Claudio
Published: September 2017

Este artigo traz à tona resultados de uma atividade desenvolvida no Facebook, em especial sobre interações discentes à luz da Sustentabilidade Ambiental (SA), como protótipo de interdisciplinaridade das Ciências. A atividade desenvolveu-se na disciplina de Seminário Integrado, como suporte a qualificação e maximização dos ambientes de ensino e aprendizagem. A metodologia abordada foi de cunho exploratório-tecnológico, partindo de uma pesquisa com perspectivas quali-quantitativa. Os dados foram extraídos diretamente da rede e, sustentados por teóricos, analisados por meio da Análise de Conteúdos e Teoria de Grafo. No término, percebeu-se que as interações nas redes sociais foram satisfatórias e suficientes para a construção de saberes interdisciplinares sobre SA, criando-se um protótipo díspar para os futuros ambientes de aprendizagem, uma vez que se configurou de forma a incentivar o educando para debater assuntos interdisciplinares de cunho pertinente, crítico e científico.
Projeto Autonomia Carioca: parceria público-privada no Ensino Fundamental do município do Rio de Janeiro (2010-2015)
Authors: Ávila Elaine Rodrigues de , Gonzalez Wania Regina Coutinho
Published: September 2017

O texto trata do Projeto Autonomia Carioca, resultante de uma parceria entre a Secretaria Municipal de Educação e a Fundação Roberto Marinho, destinado a aceleração de estudos para alunos em atraso escolar no ensino fundamental das escolas públicas municipais do Rio de Janeiro, com o uso da Metodologia Telessala. O artigo foi desenvolvido a partir da análise dos documentos oficiais e de entrevistas semiestruturadas realizadas com docentes atuantes no projeto. À luz de autores como José Carlos Libâneo Maria da Gloria Gohn e Stephen Ball, concluímos que o projeto atendeu a uma lógica gerencialista e, ao mesmo tempo, proporcionou uma educação formal não convencional a esses estudantes.
La escuela en femenino singular y masculino plural
Authors: Galet Carmen , Jiménez Ismael
Published: September 2017

La escuela es el espejo de lo que acontece en la sociedad, sin embargo, sus intentos de adaptación siempre van por detrás de los cambios que se producen en el entorno. Este artículo analiza cuáles son los comportamientos en relación al género en Educación Infantil. El estudio se centra en una revisión teórica de algunos conceptos claves y en el análisis de un centro público de la provincia de Cáceres (España). Se explora el trato de los docentes con los niños y niñas y los métodos que utilizan para abordar las cuestiones de género dentro el aula.
Understanding and Appraising Systematic Reviews and Meta-Analysis
Authors: Mittal Neeti , Goyal Manoj , Mittal Parteek K
Published: September 2017

Systematic reviews and meta-analysis seek to answer a pre-framed research question to lead to a valid answer through a systematic, explicit and reproducible method of locating; identifying, including and appraising appropriate trials. The results are synthesized considering the methodological rigor of included trials. While the meta-analysis quantitatively pools the results from individual included studies, the systematic review summarizes the findings as qualitative conclusions. These reviews are crux of evidence based dentistry for various stake-holders, i.e., clinicians, researchers and policy-makers. Although the meticulous methodology of systematic review and meta-analysis minimizes the elements of bias, yet the validity and reliability of their findings should be explored prior to translating their conclusions to practice. The goal of this paper is to familiarize readers with rationale, conduct and appraisal of systematic review and meta-analysis. Further, guidance is provided on tracing potential elements of bias in the review to enable readers to judge the quality of evidence generated from the review.
A Controlled Study of Pre-Eruptive Intracoronal Resorption and Dental Development
Authors: Al-Tuwirqi Amani , Seow W Kim
Published: September 2017

Aim: To compare the prevalence of PEIR in Australian and Saudi Arabian children and to investigate the relationship of PEIR with dental development. Study design: Panoramic (PAN) radiographs of 842 Australian and 456 Saudi children were screened for PEIR. The dental ages of the children with and without PEIR were assessed from the PAN radiographs using the method of Demirjian and co-workers. Results: The subject prevalence of PEIR was not statistically significant between Australian (2%) and Saudi children (0.6%) (p>0.1). The teeth most commonly affected by PEIR were the mandibular second molars and premolars. Dental impaction was observed in 31% of teeth with PEIR compared to only 0.1% of control teeth (p<0.0001). Children with PEIR showed a mean delay in dental development of 0.54±0.85 years compared with ageand gender-matched controls (p<0.0001). Conclusions: The present study provides the first evidence that there are no differences in PEIR prevalence between Australian and Saudi populations, and that dental development is significantly delayed in children with PEIR.
Plunging Ranula Occurring Without its Oral Counterpart: A Case Report
Authors: Shah Arpan K , Ankur Padmaja , Thakkur Rahul K
Published: September 2017

A ranula is a lesion that arises from mucin spillage from the sublingual or submandibular gland ducts, beneath the mucosa of the oral floor. A plunging or cervical ranula dissects the mylohyoid muscle and appears as a submandibular swelling. Rarely, a plunging ranula is encountered without its oral counterpart. Here, we report a rare case of a plunging ranula that occurred without its oral counterpart in a 11-year-old male patient. We have also discussed the pathogenesis and treatment options for the ranula.
Persentase Karkas Itik Peking yang Diberi Pakan dalam Bentuk Wafer Ransum Komplit Mengandung Limbah Kopi
Authors: Daud Muhammad , Mulyadi Mulyadi , Fuadi Zahrul
Published: September 2017

ABSTRAK. Penggunaan wafer ransum komplit mengandung limbah kopi pada itik peking dilakukan dengan tujuan untuk mengetahui berat akhir dan persentase karkas. Materi penelitian yang digunakan adalah itik peking umur 1 hari (DOD) sebanyak 96 ekor dibagi dalam 4 perlakuan dan 3 ulangan. Ransum yang digunakan satu bulan pertama adalah ransum komersil, dan satu bulan terakhir wafer ransum komplit mengandung limbah kopi. Ransum perlakuan yang diberikan adalah: P0 = Wafer ransum komplit 0% limbah kopi (kontrol), P1 = Wafer ransum komplit 2,5% limbah kopi, P2 = Wafer ransum komplit 5% limbah kopi, dan P3 = Wafer ransum komplit 7,5% limbah kopi. Parameter yang diamati: bobot hidup, bobot karkas, bobot potongan karkas, persentase karkas, dan persentase potongan karkas. Penelitian ini menggunakan Rancangan Acak Lengkap. Data dianalisis dengan analysis of variance dan dilanjutkan dengan Uji Duncan. Hasil penelitian menunjukkan penggunaan limbah kulit kopi sebagai bahan penyusun ransum itik peking dalam bentuk wafer ransum komplit berpengaruh nyata terhadap bobot akhir. Penggunaan limbah kulit kopi 2,5% dalam ransum secara signifikan (P0.05) meningkatkan bobot karkas dan potongan karkas. Dapat disimpulkan penggunaan limbah kulit kopi sebanyak 2,5% sebagai bahan penyusun wafer ransum komplit tidak memberi pengaruh negatif terhadap bobot badan akhir, persentase karkas dan potongan karkas itik peking.  (Carcass percentage of peking duck feed wafer complete ration containing of coffee waste) ABSTRACT. This research was conducted to study the effectiveness of wafer complete ration containing coffee waste on the final body weight and carcass percentage. The study used 96 DOD Peking duck. Completely Randomized Design (CRD) consisting of 4 treatments and 3 replications. Rations used during the first month was a commercial ration, and then subsequently wafer complete ration of coffee waste given as treatments; P0 = wafer complete ration contained 0% of coffee waste (control), P1 = wafer complete ration 2,5% of coffee waste, P2 = wafer complete ration 5% of coffee waste, and P3 = Wafer complete ration 7,5% of coffee waste. The observed variables were: final body weight, carcass weight, carcass percentage, carcass component weight, and carcass component percentage. Collected data was analyzed by ANOVA and followed by Duncan’ Multiple Range Test if there was a significant different between treatments. The results showed wafer complete ration containing coffee waste was significantly (P 0.05) effect on  final body weight. Feed containing 2,5 % of coffee waste significantly (P0.05) effect on carcass weight and carcass percentage. It is concluded that no negatif effect of wafer complete ration containing 2,5 % coffee waste on final body weight and carcass percentage of peking duck.
Efek Penggunaan Sinbiotik Terhadap Kondisi Miklofora dan Histologi Usus Ayam Sentul Jantan
Authors: Hartono Eko Fauzi , Iriyanti Ning , Suhermiyati Sri
Published: September 2017

ABSTRAK. Sinbiotik merupakan gabungan dari probiotik dan prebiotik yang dapat memperbaiki mikroflora di saluran pencernaan. Penelitian ini bertujuan mengevaluasi penggunaan sinbiotik sebagai feed aditif terhadap jumlah Bakteri Asam Laktat (BAL), Escherichia colli, histologi tinggi dan lebar vili usus. Perlakuan R0 = Pakan kontrol, R1 Sinbiotik alami (2%), R2 = Sinbiotik Alami (4%), R3 = Sinbiotik Alami (6%), R4 = Sinbiotik Komersil (2%), R5 = Sinbiotik Komersil (4%), R6 = Sinbiotik Komersil (6%). Analisis statistik yang digunakan adalah ANOVA (Analisis Varian) dan uji lanjut menggunakan Orthogonal kontras. Hasil penelitian menunjukkan pemberian sinbiotik alami berpengaruh nyata (P0,05) terhadap kondisi mikroflora usus, meningkatkan jumlah bakteri asam laktat, dan menurunkan jumlah Escherichia colli) sedangkan pemberian perlakuan sinbiotik alami berpengaruh nyata (P0,05) terhadap histologi tinggi dan lebar vili usus. Simpulan dari penelitian adalah penggunaan Sinbiotik Alami 2% dapat meningkatkan, jumlah bakteri asam laktat di duodenum, jejenum dan ileum, menurunkan bakteri Escherichia colli di ileum. Penggunaan sinbiotik komersil 4% meningkatkan, tinggi vili usus duodenum, jejenum dan ileum, dan lebar vili di ileum. (Effect synbiotic usage toward microbiological and hystological states of sentul rooster intestine) ABSTRACT. Symbiotic is a combination of probiotic and prebiotic used to improve microflora in digestive system. This study aims to evaluate the symbiotic usage as a feed additive toward the number of lactic acid bacteria, Escherichia coli, the height and the width of villi. Treatment R0 = Diet control, R1 Natural Symbiotic (2%), R2 = Natural Symbiotic (4%), R3 = Natural Symbiotic (6%), R4 = Commercial Symbiotic (2%), R5 = Commercial Symbiotic (4%), R6 = Commercial Symbiotic (6%). Statistical analysis uses ANOVA (Analysis of Variant), while further test uses orthogonal contrast. The result showed that the given symbiotic was significantly (P0,05) effect toward the condition of intestinal microflora, it increases the number of lactic acid bacteria and decreases Escherichia coli, as well as the treatment (P0,05) toward histology of the height and the width of intestinal villi. As the conclusion, the use of 2% of natural symbiotic increases the amount of lactic acid bacteria in duodenum, jejunum, and ileum, but reduces Escherichia coli in ileum, the height of intestinal villi in duodenum and the width of intestinal villi in ileum, and administered 4% of commercial symbiotic increases the height of intestinal villi in duodenum, jejunum, ileum and the width of intestinal villi in ileum.
Performan Sapi Sumba Ongole (SO) yang Diberi Jerami Padi Amoniasi dan Konsentrat yang Disuplementasi dengan Tepung Daun Waru (Hibiscus Tiliaceus)
Authors: Bata Muhamad , Rahayu Sri , Hidayat Nur
Published: September 2017

ABSTRAK. Tujuan penelitian adalah untuk mengetahui interaksi antara penambahan tepung daun waru (Hibiscus tiliaceus) (TDW) dan imbangan bahan kering (BK) jerami padi amoniasi (JPA) dan konsentrat terhadap konsumsi BK, kecernaan bahan organik (KBO) dan performan sapi Sumba Ongole (SO). Sebanyak 18 ekor sapi SO jantan dengan bobot awal 218,67 Kg ± 17,62. Pola faktorial 2 x 3 yang dirancang menurut Rancangan Acak Lengkap . Faktor pertama adalah imbangan BK JPA dan konsentrat masing-masing 35 : 65 (I1) dan 30 : 70 (I2). Konsentrat disuplementasi dengan TDW dengan level (ppm) 0% (W1), 0,24% (W2), dan 0,48% (W3)sebagai faktor kedua. Konsumsi BK tiap sapi adalah 3,3% dari bobot hidup. Penambahan tepung daun Waru (Hibiscus tiliaceus) dan imbangan BK JPA dan konsentrat maupun interaksinya tidak berpengaruh nyata (P0,05) terhadap konsumsi BK, KBO, performan sapi SO. KBO cenderung tinggi pada I1W2 dan performa cenderung baik level W3 baik pada I1 (1.27 kg ± 0.28 dan`17.21% ± 0.11) maupun I2 (1.26 kg ± 0.08 dan 19.87% ± 0.03). Penambahan tepung daun waru pada konsentrat tidak direkomendasikan untuk memperbaiki KBO maupun performan sapi SO. (Performances of sumba ongole cattle fed ammoniated rice straw and concentrate supplemented with waru leaf meal (Hibiscus tiliaceus)) ABSTRACT. The aim of this research was to find the interaction between supplementation of Hibiscus tilliaceus leaf meal (HLM) and dry matter (DM) ratio of ammoniated rice straw (ARC) and concentrate on DM intake (DMI), organic matter digestibility (OMD) and Sumba Ongole (SO) cattle performances. Eighteen of SO male cattle with the average of 21.67 Kg ±17.62 early body weight were used in this research. Completely Randomized Design with factorial pattern which consists of two factors (2 x 3) was applied. Those factors were DM ratio of ARC and concentrates of 35: 65 (I1) and 30: 70 (I2); and the concentrates that supplemented with HLM level (ppm) of 0% (W1), 0.24% (W2), and 0.48% (W3). DMI of each cattle was 3.3% of body weigh. HLM supplementation and ARC and concentrates DM ratio as well as their interaction were not significantly effected (P 0.05) on OMD, and SO cattle performances. OMD tended to increase at I1W2 and performances tended to be better at W3 both I1 (1.27 kg ± 0.28 and 17.21% ± 0.11) and I2 (1.26 kg ± 0.08 dan 19.87% ± 0.03). HLB supplementation could not be recommended to improve OMD and SO cattle performances.
Kemampuan Antibakteri Susu Fermentasi terhadap Escherichia coli dan Shigella
Authors: Hanum Zuraida , Rastina Rastina , Wanniatie Veronica
Published: September 2017

ABSTRAK. Penelitian ini dilakukan dengan menggunakan starter Lactobacillus plantarum pada konsentrasi 3%, 4% dan 5% dan diinkubasi selama 48 jam pada suhu kamar. Pengamatan terhadap susu fermentasi dilakukan selama 8 hari. Uji antibakteri ini dilakukan untuk melihat apakah susu fermentasi tersebut mampu menekan pertumbuhan patogen enterobakteri. Selanjutnya dilakukan pengujian aktivitas penghambatan mikroba dari susu fermentasi terhadap bakteri patogen dengan tiga kali ulangan. Data yang diperoleh dianalisis secara statistik menggunakan ANOVA. Hasil pengamatan menunjukkan bahwa kemampuan susu fermentasi sebagai antibakteri terhadap Escherichia coli dan Shigella flexneri terjadi pada jumlah sel sebanyak (106 CFU/ml) di dalam nutrient agar. Fermentasi susu menggunakan konsentrasi 5% starter memperlihatkan luas zona hambat tertinggi yaitu 17.42 mm terhadap E. coli pada hari kedua. Sedangkan terhadap Shigella flexneri luas zona penghambatan sebesar 8.88 mm pada hari ketiga dengan konsentrasi starter yang sama. (The antibacterial ability of fermented milk to escherichia coli and shigella flexneri)ABSTRACT. The study was performed using Lactobacillus plantarum as starter at concentrations of 3%, 4% and 5% and incubated for 48 hours at room temperature. Observation of fermented milk conducted for 8 day. The antibacterial activity test was analyzed to find whether fermented milk able to  inhibit pathogen growth. The antibacterial ability of suppressing of Enterobacteriaceae growth  observed by using Escherichia coli and Shigella flexneri (106 CFU/ml) in Nutrient Agar and challenge to fermented milk using 3%, 4% and 5% starter or about (50 µl/well). Further testing of microbial inhibitory activity of fermented milk against pathogenic bacteria conducted by three replications. The data obtained were analyzed statistically using ANOVA. The results showed that the ability of fermented milk as antibacterial on Escherichia coli and Shigella flexneri occurred in the amount of sell as much as (106 CFU / ml) when it grown in nutrient agar. As a conclusion,  fermented milk using a 5% starter showed that the highest inhibition zone of 17.42 mm to E. coli on the second day observation. While  inhibition zone of  Shigella flexnerii was 8.88 mm on the third day with the same starter concentration.
Karakteristik Sarang dan Penetasan Telur Burung Mamoa (Eulipoa wallacei) di Galela Kabupaten Halmahera Utara
Authors: Sapsuha Yusri , Sjafani Nur , Albaar Nurjana , Ishak Hasriani
Published: September 2017

ABSTRAK. Penelitian ini dilakukan untuk mengidentifikasi karakteristik sarang mamoa dan penetasan eks-situ (penetasan diluar habitat) yang menggunakan mesin tetas (inkubator) dan in-situ (di dalam habitat) secara semi alami. Penelitian survei dilakukan untuk mengetahui karakteristik sarang dan percobaan laboratorium untuk menentukan tingkat keberhasilan penetasan di habitat semi-alami di pantai Uwo uwo Kecamatan Galela pada kedalaman yang berbeda (20, 40, 60, 80 dan 100 cm). Analisis data digunakan analisis deskriptif dan analisis varian dalam program SPSS. Hasil penelitian menunjukkan bahwa karakteristik sarang peneluran pada habitat bertelur antara lain temperatur 31,88 ± 1,58 0C, dan kelembaban 67,00 ± 4,04%,. Diameter lubang 136,20 8,93 cm dan kedalaman lubang 58,17 ± 4,3 cm dan tebal timbunan 67,97 ± 4,33 cm, tingkat keberhasilan penetasan In-situ (semi alami) mencapai 100% pada kedalaman 20, 40, 60, 80 dan 100 cm dan Eks-situ (inkubator) hanya mencapai 75%. (Nest characteristics and hatching of mamoa bird egg (Eulipoa wallacei) in Galela District of North Halmahera) ABSTRACT. This study was conducted to identify the characteristics of mamoa’s nest as a basis for semi-natural and artificial hatching experiments. Survey study was to determine the characteristics of the nest (temperature, humidity) and experiments one was to determine the hatching success rate in semi-natural habitats on the beach of Uwo uwo Galela District where naturally Mamoa lays the eggs, at different depths (20, 40, 60, 80 and 100 cm). Data analysis applied was descriptive analysis and multivariate test using SPSS computer program. Results of the study showed that in the natural nesting ground temperature of 31,88 ± 1,58 oC, and humidity of 67,00 ± 4,04%. The hole diameter of 136,20 ± 8,93 cm and hole depth of 58,17 ± 4,3 cm and the thick pile of 67,97 ± 4,33 cm, hatching success rate of In-situ reached 100% at depths of 20, 40, 60, 80 and 100 cm and ex-situ is only 75%.
Potensi Tepung Ubi Jalar Ungu (Ipomea batatas L.) dalam Pembuatan Bolu Kemojo sebagai Makanan Khas Provinsi Riau
Authors: Turelanda Syahli Putra , Harun Noviar , Rahmayuni Rahmayuni
Published: September 2017

(Effect Potential Use of Purple Sweet Potato Flour ss Ingredient in Kemojo Cake, Riau Province Traditional Food) ABSTRACT. The purpose of this study was to obtain an optimal ratio of purple sweet potato flour to wheat flour to produce good quality kemojo cake product. This study uses a completely randomized design (CDR) completely randomized design (CRD) with five treatment. The analyzed of kemojo cake includes moisture content, ash content, protein content, sucrose content and sensory assessment. The result showed that  kemojo cake best treatment is TUJ2 with moisture content of 24.32%, ash content of 0.80%, protein content of 13.25%, sucrose content of 21.82% and descriptive sensory showed light purple colour (score 2.80), a hint of sweet potato flavour (score 3.00), a little bit of purple sweet potato scent (score 3.03), the chewy texture (score 3.00) and panelist favored overall (score 2.06).
A Review: Gayo Arabica Cupping Quality from Coffee Cherry to Green Bean
Authors: Hasni Dian , Rahmad Dedy
Published: September 2017

(Ulasan Ilmiah : Mutu Cita Rasa  Kopi Arabika Gayo dari Buah hingga Kopi Beras) ABSTRACT. Arabica coffee as primary commodity attracts intensive study over the years in the whole coffee sectors. This review aims to compile relevant information related to coffee botany and its production, fermentation as post-harvest process as well as the impacts of its sensory quality and composition. Many researchers prior to acknowledge that the coffee holistic production, where started from breeding to brewing ultimately affects coffee quality as beverage. Future trends attempt to determine the impact of climate change on coffee quality, processing techniques of coffee waste as well as isolation active components which impact sensory quality.
Karakteristik Pati Ubi Jalar Crem (Ipomea batatas) Termodifikasi HMT pada Berbagai Kondisi Kadar Air dan Temperatur
Authors: Muhardina Virna , Hakim Lukmanul , Zaidiyah Zaidiyah , Patria Anshar , Sulaiman Ismail
Published: September 2017

Sweet potato starch characteristic of local variety using heat moisture treatment with different level of moisture content and temperatureThe aim of this study is to modify local variety sweet potato starch (cream flesh color) in order to produce the optimal dried-noodle based starch. Native starch was maintained in varied water content (20%, 25% and 30%) and heat moisture treatment (HMT) by exposing the starch in high temperature, i.e. 90oC, 95oC, 100oC and 110oC for 3 h. The treated starch was analyzed using some parameters such as: swelling power, solubility, SEM (scanning electron microscopy) and total dietary fiber. Based on this study, swelling power shows decreasing as increasing both HMT temperature and starch water content. In other hand, solubility shows not significant different among all treatments. The treated-starch granule which is exposed to high temperature has irregular shape compared to granule in lower temperature. Furthermore, total dietary fiber shows significant different among the starch moisture content and the temperature treatment. HMT modification at 100oC and starch water content of 30% is chosen as the best results
Strengthening Empathy Training Programs for Undergraduate Social Work Students
Authors: Dupper David
Published: September 2017

Profound demographic changes as well as the introduction of religious freedom or convictions of conscience legislation in some states has made it more important than ever to equip undergraduate social work students with the knowledge and skills necessary to convey genuine empathy to clients and client groups who are stigmatized or oppressed and to use this empathic understanding to shape public policy. This article discusses the importance of enhancing current empathy training programs for undergraduate social work students by including content on implicit bias and several empirically supported strategies, including mindfulness practices, that are effective in reducing implicit bias and fostering empathy for members of stigmatized outgroups. This article concludes with an overview of instruments designed to identify, assess, and measure all aspects of interpersonal empathy and social empathy.