bluuebunny/crossref_metadata_2025 huggingface dataset:
Peritraumatic Pain in Child Maltreatment: A Systematic Literature Review
Authors: Tsur Noga , Talmon Ada , Shemesh Nofar
Published: September 2023

Extensive research has been conducted on the link between trauma, child maltreatment (CM), and chronic pain. Although the risk of suffering from chronic pain among CM survivors has been established, much less is known about the experience of pain during CM incidents or whether such peritraumatic pain sensations are associated with later chronic pain. This scoping review was conducted to synthesize the existing literature on pain during and a short time following CM (i.e., peritraumatic pain). Utilizing the preferred reporting items for systematic reviews and meta-analyses guidelines, the current review included 11 manuscripts, which met the following criteria: (a) refer to physical pain experienced during or a short time after CM, (b) were published in peer-reviewed journals, and (c) were written in English. The review demonstrated that most of the included studies were not intentionally focused on peritraumatic pain, the majority used qualitative research methods, and all were cross-sectional. Furthermore, although validated questionnaires are available, most of the studies did not utilize such measures. Those that intentionally reported pain demonstrated its high intensity and prevalence in CM incidents, indicating that pain is inherently embedded in the experience of maltreatment. The findings spotlight an underdeveloped research realm on a phenomenon that may hold significant empirical, clinical, and legal implications. Research endeavors should initiate interdisciplinary bodies of knowledge to establish well-validated research methodologies that properly quantify peritraumatic pain in trauma and CM.
Implication of Peripheral Neuropathy on Unplanned Readmissions in Patients Hospitalized for Complicated Diabetic Foot Disease
Authors: Yii Erwin , Au Amos , Bradley Justin , Saunder Alan , Bell Roger , Yii Ming K.
Published: September 2023

Introduction. Unplanned readmissions are common following discharge in patients after hospitalization for diabetic foot disease (DFD) complications. The aim of this study was to identify factors associated with readmissions in these high-risk patients, treated in a multidisciplinary setting and the implication of measures that could effectively reduce readmission rates. Methods. Patients presenting with DFDs admitted between 2015 and 2017 were studied retrospectively in a single-centre patient database. The demographics and clinical comorbidities were analyzed and comparison was made between 2 groups: patients readmitted within 30 days of discharge and those who did not require readmission. Multivariate analysis was performed to identify risk factors associated with readmissions. Results. In total, 340 patients were included. The unplanned readmission rate was 10.9%. More than half of readmissions (71%) were related to wound deterioration and infection. In the readmission group, the patients had lower body mass index, higher rate of osteomyelitis, lower rate of debridement, and evidence of peripheral vascular disease below the knee in the index admissions but these were not significant. In the multivariate analysis, peripheral neuropathy was the only significant risk associated with unplanned readmissions (odds ratio: 2.78, 95% confidence interval: 1.23-6.29, P = .014). Conclusion. This study demonstrates a significant association between peripheral neuropathy and unplanned readmissions. The implications of this nonmodifiable risk factor in reducing readmissions include all levels of patient care delivery such as adequate preparation for discharge and transition back into the community. Recognition and education in successful long-term offloading of insensate diabetic feet may help reduce rates of unplanned readmission.
Endovascular Thrombectomy With or Without Thrombolysis for Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Morsi Rami Z. , Zhang Yuan , Carrión-Penagos Julián , Desai Harsh , Tannous Elie , Kothari Sachin , Khamis Assem , Darzi Andrea J. , Tarabichi Ammar , Bastin Reena , Hneiny Layal , Thind Sonam , Coleman Elisheva , Brorson James R. , Mendelson Scott , Mansour Ali , Prabhakaran Shyam , Kass-Hout Tareq
Published: September 2023

Background

To this date, whether to administer intravenous thrombolysis (IVT) prior to endovascular thrombectomy (EVT) for stroke patients still stirs some debate. We aimed to systematically update the evidence from randomized trials comparing EVT alone vs EVT with bridging IVT.

Methods

We searched MEDLINE, EMBASE, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing EVT with or without IVT in patients presenting with stroke secondary to a large vessel occlusion. We conducted meta-analyses using random-effects models to compare functional independence, mortality, and symptomatic intracranial hemorrhage (sICH), between EVT and EVT with IVT. We assessed risk of bias using the Cochrane risk-of-bias tool and certainty of evidence for each outcome using the GRADE approach.

Results

Of 11,111 citations, we included 6 studies with a total of 2336 participants. We found low-certainty evidence of possibly a small decrease in the proportion of patients with functional independence (risk difference [RD] −2.0%, 95% CI −5.9% to 2.0%), low-certainty evidence that there is possibly a small increase in mortality (RD 1.0%, 95% CI −2.2% to 4.7%), and moderate-certainty evidence that there is probably a decrease in sICH (RD −1.0%, 95% CI −1.6% to .7%) for patients with EVT alone compared to EVT plus IVT, respectively.

Conclusion

Low-certainty evidence shows that there is possibly a small decrease in functional independence, low-certainty evidence shows that there is possibly a small increase in mortality, and moderate-certainty evidence that there is probably a decrease in sICH for patients with EVT alone compared to EVT plus IVT.
Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat–High-Sucrose Diet in a Rat Model
Authors: Abughazaleh Nada , Boldt Kevin , Rios Jaqueline Lourdes , Mattiello Stela Marcia , Collins Kelsey H. , Seerattan Ruth-Anne , Herzog Walter
Published: September 2023

Objective

Obesity and associated low-level local systemic inflammation have been linked to an increased rate of developing knee osteoarthritis (OA). Aerobic exercise has been shown to protect the knee from obesity-induced joint damage. The aims of this study were to determine (1) if resistance training provides beneficial metabolic effects similar to those previously observed with aerobic training in rats consuming a high-fat/high-sucrose (HFS) diet and (2) if these metabolic effects mitigate knee OA in a diet-induced obesity model in rats.

Design

Twelve-week-old Sprague-Dawley rats were randomized into 4 groups: (1) a group fed an HFS diet subjected to aerobic exercise (HFS+Aer), (2) a group fed an HFS diet subjected to resistance exercise (HFS+Res), (3) a group fed an HFS diet with no exercise (HFS+Sed), and (4) a chow-fed sedentary control group (Chow+Sed). HFS+Sed animals were heavier and had greater body fat, higher levels of triglycerides and total cholesterol, and more joint damage than Chow+Sed animals.

Results

The HFS+Res group had higher body mass and body fat than Chow+Sed animals and higher OA scores than animals from the HFS+Aer group. Severe bone lesions were observed in the HFS+Sed and Chow+Sed animals at age 24 weeks, but not in the HFS+Res and HFS+Aer group animals.

Conclosion

In summary, aerobic training provided better protection against knee joint OA than resistance training in this rat model of HFS-diet-induced obesity. Exposing rats to exercise, either aerobic or resistance training, had a protective effect against the severe bone lesions observed in the nonexercised rats.
Decreased Elastic Modulus of Knee Articular Cartilage Based on New Macroscopic Methods Accurately Represents Early Histological Findings of Degeneration
Authors: Maeda Takahiro , Kuriyama Shinichi , Yoshida Shigeo , Nishitani Kohei , Nakamura Shinichiro , Matsuda Shuichi
Published: September 2023

Objective

Ex vivo nanoindentation measurement has reported that elastic modulus decreases as cartilage degenerates, but no method has been established to macroscopically evaluate mechanical properties in vivo. The objective of this study was to evaluate the elastic modulus of knee joint cartilage based on macroscopic methods and to compare it with gross and histological findings of degeneration.

Design

Osteochondral sections were taken from 50 knees with osteoarthritis (average age, 75 years) undergoing total knee arthroplasty. The elastic modulus of the cartilage was measured with a specialized elasticity tester. Gross findings were recorded as International Cartilage Repair Society (ICRS) grade. Histological findings were graded as Mankin score and microscopic cartilage thickness measurement.

Results

In ICRS grades 0 to 2 knees with normal to moderate cartilage abnormalities, the elastic modulus of cartilage decreased significantly as cartilage degeneration progressed. The elastic modulus of cartilage was 12.2 ± 3.8 N/mm for ICRS grade 0, 6.3 ± 2.6 N/mm for ICRS grade 1, and 3.8 ± 2.4 N/mm for ICRS grade 2. Similarly, elastic modulus was correlated with Mankin score ( r = −0.51, P < 0.001). Multiple regression analyses showed that increased Mankin score is the most relevant factor associated with decreased elastic modulus of the cartilage ( t-value, −4.53; P < 0.001), followed by increased histological thickness of the cartilage ( t-value, −3.15; P = 0.002).

Conclusions

Mechanical properties of damaged knee cartilage assessed with new macroscopic methods are strongly correlated with histological findings. The method has potential to become a nondestructive diagnostic modality for early cartilage damage in the clinical setting.
The zooming-speed illusion: A meta illusion?
Authors: Ashida Hiroshi , Kitaoka Akiyoshi
Published: September 2023

A movie taken from the front window of a running train, with zooming in and out, has been popularly acknowledged as a perceptual illusion such that the train motion is perceived as much slower when zoomed in. This is, however, not a real illusion because the image speed varies as a function of the focal length of the lens. This could be a meta-illusion, that is, an illusory sense of illusion, that might reflect a lack of understanding of how zooming changes the geometrical structure of the image.
HIV/AIDS patients’ knowledge, attitude, and practice toward anti-retroviral therapy medications’ adverse effects and associated factors in Tikur Anbessa Specialized Hospital
Authors: Negash Zenebe , Yibeltal Yohannes , Ayele Akeberegn Gorems
Published: September 2023

Background:

Adverse effects (AEs) have been reported with all antiretroviral therapy (ART) medications, and it was among the most common cause for switching or terminating therapy and drug non-adherence. Even though AEs of ART medications are common and to be expected, little study has been conducted on the understanding of patients on the AEs. Therefore, this study aimed to assess patients’ knowledge, attitude, and practice (KAP) toward ART medications’ AEs and associated factors.

Methods:

A cross-sectional study design was applied using an interviewer-administered questionnaire from June to September 2021 on human immunodeficiency virus/acquired immunodeficiency syndrome patients on follow-up at Tikur Anbessa Specialized Hospital, Ethiopia. Data was gathered, cleaned, and analyzed using SPSS version 23. Logistic regression analysis was performed to assess the relationship between the independent variable and patients’ knowledge and attitude about the AEs of ART medication. A p-value of 0.05 was used to determine the statistical significance.

Results:

About 230 people were enrolled in this study, with 51.3% of them female. Study participants had a mean age of 36 years (standard deviation = 14.19). Of 230 participants, 67.8% had received advice on the AEs of ART medications. Poor knowledge and attitude were observed among 47.8 and 51.3% of respondents, respectively. Prior AEs experience, lack of experiencing opportunistic infection, and lack of counseling about ART medications’ AEs were associated with poor knowledge, whereas female gender and a lack of counseling regarding ART medications’ AEs were associated with a negative attitude ( p < 0.05). Even though most patients (81.7%) report AEs of the medication to professionals, a significant number of patients involved in malpractices such as taking other drugs to treat AEs (24.3%), not prepared to do anything (27.1%), change the suspected drug (24.3%), reduce the dose (18.7%), and use local herbal medicines to treat suspected AEs (20.2%).

Conclusion:

Overall, the study participants had poor knowledge, lack of positive attitudes, and non-adherence to the actual recommended practice toward AEs of ART medications. Lack of comorbidity, having prior AEs experience, and lack of counseling regarding ART medication AEs were associated with poor knowledge. Female gender and a lack of counseling on the AEs of ART medications were associated with a negative attitude.
An evaluation of risk factors for readmission in patients receiving outpatient parenteral antimicrobial therapy
Authors: Bradley Abby C. , Wingler Mary Joyce B. , Artman Katherine L. , Ward Lori M. , Lucar Jose
Published: September 2023

Background:

Outpatient parenteral antimicrobial therapy (OPAT), when required, is beneficial to patients and healthcare systems by reducing hospital length-of-stay, providing cost savings, and improving patient satisfaction.

Objectives:

The purpose of this study is to determine readmission rates and associated risk factors in patients receiving OPAT at home.

Methods:

This retrospective study included hospitalized patients 15 years and older who were discharged on intravenous antimicrobial therapy via OPAT at home between January 2018 and December 2019. Patients receiving antimicrobials at a skilled nursing facility, long-term acute care, or dialysis center, and those who began OPAT at home directly from the outpatient setting were excluded. The primary outcome of this study was all-cause 30-day readmission rate. Secondary outcomes included 90-day readmission rate, rates of complications related to OPAT, emergency department visits during OPAT, and predictors of all-cause 30-day readmission through a logistic regression analysis.

Results:

Two hundred individual patients were included in the analysis; 60% were male and the mean age was 49 years. The most common indications for OPAT at home were bone and joint infection (52%) and bacteremia (26%). Forty patients (20%) experienced an unplanned, all-cause 30-day readmission, with a total of 48 readmission events. Of the 40 patients who were readmitted within 30 days, 20 (50%) were due to non-OPAT related reasons. Sixty patients (30%) experienced an OPAT-related complication, and chronic kidney disease was found to be an independent predictor of readmission (OR: 2.8, 95% CI: 1.0–7.6).

Conclusions:

Patients receiving OPAT at home are at increased risk for early hospital readmission, but it is often due to reasons not associated with OPAT. Patients with chronic kidney disease beginning OPAT at home should be closely monitored after discharge.
Case report: Probable toxocariasis in a Swiss adult patient with hypereosinophilic syndrome and multiorgan involvement
Authors: Henke Katrin , Perunovic Cicovic Tanja , Ziaka Mairi
Published: September 2023

Hypereosinophilic syndromes are a heterogeneous group of rare diseases characterized by eosinophil-related organ damage and peripheral blood hypereosinophilia. Hypereosinophilic syndromes may occur secondary to a variety of clinical entities, for example, drug hypersensitivity reactions, parasitic infections, autoimmune disorders, and malignancies. Toxocariasis is a parasitic infection caused by the larval stage of the Toxocara species. It is usually a childhood disease and invades organs such as the liver but can affect any organ. Hypereosinophilic syndrome and multiorgan involvement are very rare manifestations of Toxocara infection, especially in adults. However, the disease may be underdiagnosed because of different factors, including a lack of laboratory infrastructure in some countries, a lack of uniform case definitions, and limited surveillance infrastructure, with its estimation constituting a challenge. We, therefore, present a probable case of hypereosinophilic syndrome with multiorgan involvement secondary to infection with Toxocara canis in a 79-year-old Swiss female patient with a medical history of ischemic cerebrovascular insult and a curatively resected non-small-cell bronchial carcinoma, successfully treated with albendazole and steroids.
MDMA-assisted psychotherapy with adolescents suffering from PTSD: Do or don’t? a qualitative study with youth, parents, and clinicians
Authors: van Vugt Anoek S , Zijlmans Josjan , Lindauer Ramon , van Dam Levi
Published: September 2023

Background

PTSD in adolescence causes much suffering and has substantial health-care costs. Many patients with severe PTSD do not respond to psychotherapy or continue to have symptoms despite trauma-focused psychotherapies and psychopharmacological treatment. A recent alternative in the search for cost-effective treatments for PTSD in adults is 3,4-methylenedioxymethamphetamine-assisted psychotherapy (MDMA-assisted psychotherapy). However, no research has yet been conducted on the therapeutic potential of MDMA for adolescents.

Aims of the study

The purpose of this study is to investigate the perspectives of adolescents, parents, and clinicians about the possible clinical application of MDMA-assisted psychotherapy for adolescents with PTSD.

Method

We performed focus groups in three samples: (a) 16–24-year-olds who had undergone trauma therapy ( N  =  9), (b) parents of traumatized children ( N  =  4), and (c) trauma clinicians ( N  =  6). Focus group topics included: perception of and associations with MDMA, opinions on MDMA-assisted psychotherapy, risks/benefits, and precautions to take prior to possible adolescent clinical trials with MDMA-assisted psychotherapy.

Results

In all groups, initial participant attitudes towards MDMA were predominantly unfavorable, except for several adolescents who had conducted preliminary research on the subject. After a standardized explanation of MDMA-assisted psychotherapy, provided in each group, all but one participant changed their minds and supported the idea of implementing MDMA-assisted psychotherapy for adolescents. They all emphasized the importance of conducting research first.

Conclusion

Our findings suggest that when provided with information on what MDMA-assisted psychotherapy entails, adolescents, parents, and clinicians are open to the idea of exploring this type of treatment for adolescents.
You Can (Not) Say What You Want: Using Algospeak to Contest and Evade Algorithmic Content Moderation on TikTok
Authors: Steen Ella , Yurechko Kathryn , Klug Daniel
Published: September 2023

Social media users have long been aware of opaque content moderation systems and how they shape platform environments. On TikTok, creators increasingly utilize algospeak to circumvent unjust content restriction, meaning, they change or invent words to prevent TikTok’s content moderation algorithm from banning their video (e.g., “le$bean” for “lesbian”). We interviewed 19 TikTok creators about their motivations and practices of using algospeak in relation to their experience with TikTok’s content moderation. Participants largely anticipated how TikTok’s algorithm would read their videos, and used algospeak to evade unjustified content moderation while simultaneously ensuring target audiences can still find their videos. We identify non-contextuality, randomness, inaccuracy, and bias against marginalized communities as major issues regarding freedom of expression, equality of subjects, and support for communities of interest. Using algospeak, we argue for a need to improve contextually informed content moderation to valorize marginalized and tabooed audiovisual content on social media.
Electoral competition, district party fragmentation and environmental policy outcome: Empirical evidence from Indonesia
Authors: Sasmi Dini Tiara , Park Jongho
Published: September 2023

This paper explores how party fragmentation and electoral competition relate to the outcome of environmental policy. It is assumed that when elections happen the electoral punishment and incentives will be distributed. Specifically, when there are high number of effective number parties (ENP) in the legislature, it brings competition to the incumbent to provide more public goods. Hence, the electoral competition and party fragmentation will bring more provision of public goods. Using these assumptions, the electoral competition theory provides basic pieces of information to predict the effect of electoral competition on environmental policy outcome; a high ENP will provide a better outcome of environmental policy. Taking Indonesia as our case selection, we discovered a positive association between the number of effective parties and energy efficiency, such as LED, and a negative correlation between the usage of wood for domestic fuel. This means that political competition such as electoral competition promotes better outcome for environmental policy.
Performance Assessment of Anti-Xa Assay–Based Heparin Dosing Protocol in Pediatric Patients on Extracorporeal Membrane Oxygenation
Authors: Al-Jazairi Abdulrazaq S. , Shorog Eman M. , Owaidah Tarek M. , Al dalaty Hani , Alheriash Yasser A. , Almehizia Rayd A. , Alahmadi Mamdouh D.
Published: September 2023

Background

The use of extracorporeal membrane oxygenation (ECMO) in the postoperative cardiac critical care setting is evolving. Anticoagulation monitoring is among the most challenging aspects of pediatrics. However, there is no consensus on the optimal dosing and monitoring of unfractionated heparin in this setting. To address this, we developed an anti-Xa assay–based protocol derived from the best available clinical and anecdotal evidence of ECMO use and assessed its effectiveness in achieving the anti-Xa assay therapeutic target.

Methods

This prospective single-arm study was conducted in the pediatric carcardiac-surgery intensive care unit of a large tertiary hospital. We used two different anti-Xa assay intensity levels based on the patients’ bleeding status.

Results

The median patient age was 7 (interquartile range [IQR]: 5-11.25) months, and the median weight was 5.7 (IQR: 3.8-13.82) kg. The median ECMO duration was 6 (IQR: 4.5-7.5) days. The bleeding protocol was used for most patients. Seventy percent achieved the anti-Xa assay therapeutic target during the study period (median: 75.5 h, IQR: 60.5-117.5 h). Hemorrhagic complications were reported in 40% of the patients, and thrombotic complications were reported in 25%. The median length of stay was 37 (IQR: 22-43) days, with a survival-to-discharge rate of 75%.

Conclusions

Despite a failure to achieve the anti-Xa assay target within the first ECMO days, most patients achieved the target by the median ECMO duration. Moreover, using two different anti-Xa assay levels reduced thrombotic complications.
Message Framing and Attitudes Toward Green Gas Facilities in Rural Communities of The Netherlands
Authors: van Dijk Mathilde , Smit Annet-Jantien , Nap Jan-Peter
Published: September 2023

Green gas is an attractive option for a local energy transition to combat climate change, notably in rural communities. As local initiatives require local acceptance, the study used a questionnaire methodology to capture opinions and intentions toward green gas in a panel of rural respondents ( N = 403) and evaluated the green gas message framing to help improve communication strategies. This survey experiment used four frames in a 2 × 2 setup: an energy value core frame of responsibility for nature versus autonomy and a focus frame emphasizing the collective ( i.e., the community) versus the individual (i.e., the household). Our findings highlight that the association with sustainability proves vital for a positive assessment of green gas, but its affordability is an issue. Moderated mediation analysis showed that subjective knowledge moderates between frames and intentions toward green gas: responsibility for nature contributes significantly, but only in the collective focus frame. These results are valuable in creating effective communication strategies about green gas adoption in the future.
Factors Influencing the Effectiveness of Open Government Data Platforms: A Data Analysis of 61 Prefecture-Level Cities in China
Authors: Chu Jinhua , Dai You-Yu , Zhong Anyuan
Published: September 2023

Information disclosure, participatory governance, and collaborative innovation are open government data’s (OGD) main goals. Understanding the preconditions that enable the efficient and effective implementation of OGD initiatives is essential for achieving their overall objectives. Therefore, determining its influencing factors helps improve platform quality, prevent misunderstanding, and realize the purpose of OGD. Based on the literature, this study established a user-oriented conceptual model of OGD into which technology acceptance theory was integrated. This model constructed a data analysis model with the number of downloads of OGD platform data as the response variable and the explanatory variables comprising OGD quality score, linked data density, time to inception, and five others. Sixty-one cases of OGD platforms in Chinese prefecture-level cities were analyzed. The results indicated that the effectiveness of OGD was positively correlated with OGD quality score, time to inception, and the number of employees in the case cities. Network density and average disposable income of citizens had non-significant impacts on effectiveness. Strategies for improving the effectiveness of OGD platforms in China were discussed.
Prevalence of premature ovarian insufficiency (POI) and its relationship with female reproductive factors in Iranian women: a cross-sectional study from the Persian (Shahedieh) cohort data
Authors: Jambarsang Sara , Khodayarian Mahsa , Sefidkar Reyhane , Yoshany Nooshin
Published: September 2023

Background

In premature ovarian insufficiency, the cessation of menstruation, and cessation of ovarian function occurs before the age of 40, and this phenomenon is associated with many complications and problems for women. Since several factors can affect this situation, this study was conducted to determine the relationship between fertility history, and premature ovarian failure.

Methods

This cross-sectional study was conducted on the data of the first phase of cohort study, which was a sample of 10,000 people from an Iranian adult population (age: 35–70 years). 1276 women were included who naturally experienced menopause from this population. They were separated into three groups based on the age of menopause: premature ovarian failure for those who reached menopause before the age of 40, early menopause for those who reached menopause between the ages of 40 and 45, and natural menopause for those who reached menopause at or after the age of 45. The demographic and fertility characteristics of two groups of women, one with premature ovarian failure and the other with early menopause, were compared with a group of women experiencing normal menopause. The comparison was based on frequency and percentage. Moreover, the odds ratio (OR) of these two groups compared to normal group was crudely calculated, and adjusted based on age at the time of the interview using a logistic regression model. SPSS 23 software was used to fit models and calculations.

Results

The prevalence of premature ovarian failure was 3%. The likelihood of premature ovarian failure decreases as the number of live births rises. The risk is considerably higher for births ranging from zero to three children compared to those with more than four. Increased duration of breastfeeding is associated to a reduced risk of premature ovarian failure compared to the spontaneous occurrence (OR = 0.98, 95% CI (0.97, 0.99)). This relationship is maintained even after adjusting for age (OR = 0.98, 95% CI (0.97, 0.99).

Conclusion

Based on the results of present study, it can be concluded that the factor of the number of births, and the duration of breastfeeding affect reducing the occurrence of POI, therefore, in health and treatment programs and policies, encouragement to have children, which is now part of the policies population of Iran, and the importance, and benefits of breastfeeding for mother and baby should be emphasized more.
Gastroblastoma without GLI1 and EWSR1 gene breaks
Authors: Gong Can , Xu Junyi , Qiao Shuye , Zhang Xuemei , Yi Min
Published: September 2023

Objective

To report a rare gastroblastoma; discuss its clinical features, histopathological morphology, diagnosis, differential diagnosis, treatment, and prognosis; and so as to improve the understanding on this disease and provide reference for its diagnosis, treatment, and prognosis.

Methods

The diagnosis and treatment, imaging examination, pathological, and genetic data of a 19-year-old young female patient with gastroblastoma were analyzed retrospectively, and the relevant literature was reviewed and summarized.

Results

The patient was found to have a “gastrointestinal stromal tumor” for 3 days by physical examination in another hospital. Abdominal CT and MRI considered “solid pseudopapilloma of pancreas” and clinically planned to perform “radical pancreatoduodenectomy.” During the operation, the tumor was observed to bulge from the posterior wall of the gastric antrum, and the root was located in the gastric antrum, so it was changed to “partial gastrectomy + Ronx-y gastrojejunal anastomosis.” The postoperative pathology showed that the tumor was bi-differentiated between gastric epithelium and mesenchymal. Combined with the results of IHC and the opinions of several consultation units, the diagnosis of gastric blastoma (low-grade malignancy) was supported. However, the fracture rearrangement of GLI1 and EWSR1 genes was not detected by FISH. After 19 months of follow-up, no signs of tumor recurrence and metastasis were found.

Conclusion

Combined with existing literature reports, gastroblastoma occurs in young people, equally in men and women, and tends to occur in the gastric antrum. The biological behavior of the tumor tends to be inert, and the prognosis of most cases is good. Postoperative pathology and IHC are reliable methods for the diagnosis of gastric blastoma, and surgical resection of the lesion is the preferred treatment.
Breastfeeding needs of mothers of preterm infants in China: a qualitative study informed by the behaviour change wheel
Authors: Yu Yaqi , Liu Qianru , Xiong Xiaoju , Luo Ying , Xie Wen , Song Wenshuai , Fu Maoling , Yang Qiaoyue , Yu Genzhen
Published: September 2023

Background

Although breastfeeding is strongly recommended, the breastfeeding rate of preterm infants in China remains significantly low. In addition to the global structural challenges to breastfeeding and the physiological immaturity of preterm infants, Chinese mothers of preterm infants face unique challenges of maternal-infant separation after birth. Moreover, little is known about Chinese mothers’ specific needs in coping with the difficulties posed by these challenges. This study utilized the Behaviour Change Wheel to investigate the breastfeeding needs of Chinese preterm mothers that may facilitate its practice in the future.

Method

A qualitative descriptive design was implemented in Wuhan in 2022. Based on purposeful sampling, 13 preterm mothers were recruited from a NICU in a Grade III Class A hospital in Wuhan, China. Face-to-face semi-structured interviews were conducted to collect data using the interview guide developed by the Theoretical Domains Framework. Theoretical Thematic Analysis was used to review the data in 6 steps to identify themes.

Results

Five major themes emerged: (1) capability: ability to interpret infants’ cues and identify problems, and need for breastfeeding knowledge and skills training; (2) physical opportunity: cleanliness and quietness in household environment, private lactation spaces and breastfeeding tools in workplaces and hospitals; (3) social opportunity: family support, peer support, and authoritative support from healthcare providers; (4) reflective motivation: information on health impacts of breastfeeding; (5) automatic motivation: maternal-infant bonding, free of aversive stimulus.

Conclusion

Preterm mothers’ needs to enable breastfeeding were diverse, including increasing their capability, physical and social opportunities, and reflective and automatic motivation. People, resources and environments associated with these needs should be engaged together to stablish a conducive structural environment for breastfeeding. The policy change for “zero separation” and implementation of kangaroo care should also be implemented in Chinese neonatal intensive care units. Future studies are needed to design effective interventions according to mothers’ specific needs.
Factors related to information and communication technologies adoption in small businesses in Colombia
Authors: Duran Julian , Castillo Rubén
Published: September 2023

This study is an analysis of how a set of factors influenced the decision to adopt information and communication technologies (ICTs) in small businesses in Colombia; for this purpose, a logistic modeling is applied, wherein the explained variable represents the companies’ decision to adopt ICTs. The main explanatory elements include demographic aspects of the owner, the company characteristics, and the legal practice of the company and its social capital. Data from the Microbusiness Survey 2019 conducted by the National Administrative Department of Statistics of Colombia were employed. The results show that traits such as owner age and gender affect adoption. Furthermore, variables such as the age and size of the company, the amount of computer equipment, business formalization practices, and social capital influence the use of these technologies. Therefore, it follows that the individual features of business owners are also determinants of technology adoption, and their inclusion becomes essential to supplement the analysis of these issues. In addition, the study supports the evidence that the acceptance of these technologies is positively related to the business size and infrastructure. By exploring, for example, the business formalization factor, a positive effect is obtained; consequently, the implementation of legal practices is linked to the ICT use. Thus, some of the areas for policy implementation would be, on one hand, the endowment of computer equipment, since it is a critical aspect in these small businesses, for which a subsidy policy for the acquisition of devices would be useful. In addition, the promotion of business formalization practices could lead to an improvement in the firm’s culture of technology use.
Industrial policy and labour productivity growth in Africa: does the technology choice matter?
Authors: SIÉ Kouakou Jean Fidele
Published: September 2023

The persistent gaps in African sectoral labour productivity and the disappointing growth in the manufacturing and service sectors have revived interest among academics and policymakers. In search of ways to boost labour productivity, this study explores how the technology choice as a proxy for industrial policy can affect labour productivity growth. First, I identify the different sources of growth with the decomposition method of shift–share analysis and a recent dataset from 1960 to 2017 of nine sectors. Then I investigate the impact of comparative advantage development strategy on growth components (within effects and structural effects). The shift and share decomposition analysis results suggest a changing role of growth components. While the structural change effect is driven by the “static gains” which still plays an important role, the within effect has been more prevalent during the MDGs and SDGs period. The empirical results indicate that defying comparative advantage hinders the within effect component mitigated by a weak and positive dynamic effect component. The evidence emphasises the design of industrial development based on the comparative advantage in SSA, complemented with policies and strategies aiming at increasing labour productivity in the agriculture sector due to its large employment share.
Socioeconomic factors of global food loss
Authors: Chrisendo Daniel , Piipponen Johannes , Heino Matias , Kummu Matti
Published: September 2023

A considerable amount of food produced is lost globally. Food loss indicates not only the amount of edible food that humans do not consume but also the waste of resources used in production and distribution, linked with multifold problems such as climate change, biodiversity loss, and economic loss. While there has been a growing body of literature about magnitudes and technical solutions to reduce food loss, little is known about how different socioeconomic factors are potentially related to the losses. Here we assess the relationships between various relevant socioeconomic factors and food loss within the early stages of the food supply chain (i.e., farm, harvest, storage, and transport parts of it) using the most comprehensive data available. We found that factors such as high gross national income (GNI) per capita and high employment in agriculture are significantly associated with low food loss. It suggests that income might be invested in technology or infrastructure while labor is still vital to reduce food loss, especially in technology-inferior countries. Other important factors related to low food loss are access to electricity in rural areas and export volume index, although the significance and directions vary in each commodity and food supply stage. Our results provide valuable insights into socioeconomic factors around food loss that are beneficial to formulating relevant policy, especially in countries where substantial food losses in the early stages of the food supply chain considerably risk to food security.
Genetics in ophthalmology: molecular blueprints of retinoblastoma
Authors: Marković Leon , Bukovac Anja , Varošanec Ana Maria , Šlaus Nika , Pećina-Šlaus Nives
Published: September 2023

This review presents current knowledge on the molecular biology of retinoblastoma (RB). Retinoblastoma is an intraocular tumor with hereditary and sporadic forms. 8,000 new cases of this ocular malignancy of the developing retina are diagnosed each year worldwide. The major gene responsible for retinoblastoma is RB1, and it harbors a large spectrum of pathogenic variants. Tumorigenesis begins with mutations that cause RB1 biallelic inactivation preventing the production of functional pRB proteins. Depending on the type of mutation the penetrance of RB is different. However, in small percent of tumors additional genes may be required, such as MYCN, BCOR and CREBBP. Additionally, epigenetic changes contribute to the progression of retinoblastoma as well. Besides its role in the cell cycle, pRB plays many additional roles, it regulates the nucleosome structure, participates in apoptosis, DNA replication, cellular senescence, differentiation, DNA repair and angiogenesis. Notably, pRB has an important role as a modulator of chromatin remodeling. In recent years high-throughput techniques are becoming essential for credible biomarker identification and patient management improvement. In spite of remarkable advances in retinoblastoma therapy, primarily in high-income countries, our understanding of retinoblastoma and its specific genetics still needs further clarification in order to predict the course of this disease and improve therapy. One such approach is the tumor free DNA that can be obtained from the anterior segment of the eye and be useful in diagnostics and prognostics.
Identification and cross-country comparison of students’ test-taking behaviors in selected eTIMSS 2019 countries
Authors: Zheng Xiaying , Sahin Fusun , Erberber Ebru , Fonseca Frank
Published: September 2023

Unfavorable test-taking behaviors, such as speededness and disengagement, have long been a validity concern for large-scale low-stakes assessments. Understanding the presence and extent of such behaviors is important for ensuring the validity of inferences based on test scores. This study examined test-taking behaviors using item response time (RT), a process data-derived variable from the TIMSS 2019 database. Analyses compared the United States to three other countries (England, Singapore, and the United Arab Emirates) that administered the digital version of TIMSS (eTIMSS) 2019 in English at grade 8. Test-taking behaviors were identified within each country and compared within and across countries. Specifically, to identify distinct types of test-taking behaviors, mixture modeling was employed on RT and item scores from Booklet 1, Part 1, of the eTIMSS 2019 eighth-grade assessment. The results indicated that each country had several latent classes of students with different pacing trajectories and performance. The test-taking behaviors of these latent classes were labeled as Steady; Disengaged or Very disengaged; Speeded or Very speeded; and Efficient and high-performing. Most of the students in each country had a Steady pace (medium to high sum score; steady RT throughout the test): 71% in England, 74% in both Singapore and the United Arab Emirates, and 84% in the United States. Disengaged or Very disengaged students (low sum score; short RT) were identified in each country but were more prevalent in England and the United Arab Emirates (above 20% in both) than in the United States and Singapore (both below 10%). The study also revealed small percentages of Speeded or Very speeded students (low to medium sum score; long RT at first but very short RT toward the end) in England, the United Arab Emirates, and the United States (1%, 5%, and 6%, respectively) but not in Singapore. A unique class of Efficient and high-performing students (high sum score; short RT) was identified only in Singapore (24%). This study demonstrated that mixture modeling is a useful technique for identifying distinct test-taking behaviors and highlighted the presence and extent of unfavorable test-taking behaviors within each selected country using data from Booklet 1, Part 1, of the eTIMSS 2019 eighth-grade assessment.
Functional and structural changes in the neuroretina are accompanied by mitochondrial dysfunction in a type 2 diabetic mouse model
Authors: Lam Christie Hang-I , Zou Bing , Chan Henry Ho-Lung , Tse Dennis Yan-Yin
Published: September 2023

Background

Diabetic retinopathy (DR), one of the leading causes of blindness and vision impairment, is suggested to exhibit functional and structural changes in retinal neurons as the earliest manifestation, which could be used to predict the progression of related angiopathy. While neural function and survival rely on proper mitochondrial function, and a growing body of literature has supported the role of mitochondrial dysfunction in the development of DR, how diabetes affects mitochondrial function in retinal tissue remains elusive. This study primarily aimed to investigate mitochondrial functional changes in a diabetic rodent model. We also characterized the early DR phenotype, in particular, neurodegeneration.

Methods

C57BLKsJ-db/db (db/db) mice (a type 2 diabetic mouse model) were used with their normoglycemic heterozygous littermates (db/+) serving as controls. Longitudinal changes in retinal function and morphology were assessed with electroretinography (ERG) and optical coherence tomography (OCT), respectively, at 9, 13, 17, and 25 weeks of age. At 25 weeks, the retinas were harvested for immunohistochemistry and ex vivo mitochondrial bioenergetics.

Results

Decreased ERG responses were observed in db/db mice as early as 13 weeks of age. OCT revealed that db/db mice had significantly thinner retinas than the controls. Immunohistochemistry showed that the retinas of the db/db mice at 25 weeks were thinner at the outer and inner nuclear layers, with lower photoreceptor and cone cell densities compared with the db/+ mice. The number of rod-bipolar cell dendritic boutons and axon terminals was significantly reduced in db/db mice relative to the db/+ mice, suggesting that diabetes may lead to compromised synaptic connectivity. More importantly, the retinas of db/db mice had weaker mitochondrial functions than the controls.

Conclusions

Our longitudinal data suggest that diabetes-induced functional deterioration and morphological changes were accompanied by reduced mitochondrial function in the retina of db/db mice. These findings suggest that mitochondrial dysfunction may be a contributing factor triggering the development of DR. While the underlying mechanistic cause remains elusive, the db/db mice could be a useful animal model for testing potential treatment regimens targeting neurodegeneration in DR.
Experimental study of effect of infill density on tensile and flexural strength of 3D printed parts
Authors: Karad Akshay S. , Sonawwanay Puskaraj D. , Naik Mahesh , Thakur D. G.
Published: September 2023

Additive manufacturing (AM) is an innovative procedure that can quickly create complex structures. By layering a material, a three-dimensional object is created using this technique. Every deposit of liquefied or partly liquefied material abides by the previous deposit. Fused deposition modelling’s (FDM) objective is to comprehend how varied interior structures influence the bending resistance of the printed samples and to investigate the impact of various infill patterns and percentages. The term “infill” describes the pattern of solid material used to fill a 3D-printed object's interior. It is utilized to give the printed part structural support and strength. Acrylonitrile butadiene styrene (ABS) material was chosen for this study as it offers a greater and superior finished plane along with dimensional stability. The infill pattern chosen for the flexural test study was the triangular pattern which includes different densities of infill percentages precisely, 25%, 50%, 75%, and 100%. A few specimens of ABS material having 100% infill density are put through a tensile test according to the ASTM D638. The ASTM D790 standard was used to make a model and test the flexural strength of the specimen. Line and triangle patterns provided the most ideal tensile and bending strength properties. This is likely because the deposited rasters are associated with the direction of loading. For line patterns with 100% infill, scanning electron microscopy (SEM) analysis showed a convincing connection between the microstructures and the rasters (porosity, voids, gap between beads and hole due to polymer pulled out). Furthermore, SEM analysis showed matrix failure and significant voids in a triangular pattern at infill densities of 25%, 50%, 75%, and 100%.
Footprint of fresh submarine groundwater discharge in the Belgian coastal zone: An overview study
Authors: Paepen Marieke , Walraevens Kristine , Hermans Thomas
Published: September 2023

The presence of fresh groundwater is not limited to land; it also extends offshore and discharges as submarine groundwater discharge (SGD). The freshwater component of SGD (fresh submarine groundwater discharge [FSGD]) can be detected using geophysical techniques that are sensitive to salinity such as resistivity measurements. However, these measurements are often limited to either the land or marine realm, neglecting the land-marine interface. In this study, we focus on this gap by combining onshore and offshore techniques to assess variability in the FSGD footprint near the Belgian coastline through electrical resistivity tomography and continuous resistivity profiling. The difficult working conditions of the highly dynamic North Sea make this offshore survey one of the first of its kind. The footprint varies from limited outflow on the upper beach (e.g., Wenduine) to discharge around and below the low water line (e.g., De Panne, Oostduinkerke, and Knokke-Heist) in the studied areas. The occurrence, footprint, and quantity of SGD seem to be controlled by the presence and size of dune formations that constitute freshwater resources along the shore. Heterogeneity can also play a determining factor in FSGD location.