bluuebunny/crossref_metadata_2025 huggingface dataset:
Magnetic Resonance Image Radiomic Reproducibility: The Impact of Preprocessing on Extracted Features from Gross and High-Risk Clinical Tumor Volumes in Cervical Cancer Patients before Brachytherapy
Authors: Sadeghi Mahdi , Abdalvand Neda , Mahdavi Seied Rabi , Abdollahi Hamid , Qasempour Younes , Mohammadian Fatemeh , Birgani Mohammad Javad Tahmasebi , Hosseini Khadijeh , Hazbavi Maryam
Published: August 2024

Background:

Radiomic feature reproducibility assessment is critical in radiomics-based image biomarker discovery. This study aims to evaluate the impact of preprocessing parameters on the reproducibility of magnetic resonance image (MRI) radiomic features extracted from gross tumor volume (GTV) and high-risk clinical tumor volume (HR-CTV) in cervical cancer (CC) patients.

Methods:

This study included 99 patients with pathologically confirmed cervical cancer who underwent an MRI prior to receiving brachytherapy. The GTV and HR-CTV were delineated on T2-weighted MRI and inputted into 3D Slicer for radiomic analysis. Before feature extraction, all images were preprocessed to a combination of several parameters of Laplacian of Gaussian (1 and 2), resampling (0.5 and 1), and bin width (5, 10, 25, and 50). The reproducibility of radiomic features was analyzed using the intra-class correlation coefficient (ICC).

Results:

Almost all shapes and first-order features had ICC values > 0.95. Most second-order texture features were not reproducible (ICC < 0.95) in GTV and HR-CTV. Furthermore, 20% of all neighboring gray-tone difference matrix texture features had ICC > 0.90 in both GTV and HR-CTV.

Conclusion:

The results presented here showed that MRI radiomic features are vulnerable to changes in preprocessing, and this issue must be understood and applied before any clinical decision-making. Features with ICC > 0.90 were considered the most reproducible features. Shape and first-order radiomic features were the most reproducible features in both GTV and HR-CTV. Our results also showed that GTV and HR-CTV radiomic features had similar changes against preprocessing sets.
Assessing parosmia patients: a study on the evaluation method using a self-administered odor questionnaire for parosmia
Authors: Tei M , Mori E , Yonezawa N , Kishimoto Y , Tanaka H , Yanagi N , Tsurumoto Y , Nagai M , Sekine R , Otori N , Tsuzuki K
Published: August 2024

Background: Parosmia symptoms are difficult to quantify due to their heterogeneity among patients, and thus a clinical challenge. This study aimed to assess parosmia with Self-Administered Odor Questionnaire for Parosmia (SAOQ-P), a modification of the widely used SAOQ in Japan. The primary objective was to assess the effectiveness of SAOQ-P in identifying parosmia symptoms and its potential integration into the clinical assessment process. The study also explored traditional olfactory test differences between patients with and without parosmia. Methods: Patients at Jikei Smell Clinic that presented between May 2022 and November 2022 were recruited and administered the SAOQ-P, which had an added question about changes in the perception of 20 daily odors compared to the original SAOQ. Traditional olfactory tests utilized T&T olfactometry and Open Essence. Results: Of 279 patients, 81 had parosmia, while 198 did not exhibit parosmic symptoms. Parosmia prevalence was influenced by the cause of olfactory dysfunction, with post-infectious and post-COVID-19 patients showing higher parosmia rates. Among parosmia patients, 87% reported changes in their perception of at least one odor assessed by SAOQ-P, with coffee, stool, and perfume most commonly affected. Traditional olfactory tests showed no significant differences between parosmia and non-parosmia groups. The number of odors causing parosmia was negatively correlated with age. Conclusion: SAOQ-P offers a promising approach to assess and quantify parosmia symptoms, seamlessly integrating into clinical assessments. SAOQ-P identified parosmia in 87% of patients and revealed insights into triggering factors. Traditional olfactory tests' limitations underscore the need for more accurate, patient-centric diagnostic approaches for parosmia.
Importance of early detection of esophageal cancer before the tumor progresses too much for effective treatment
Authors: Ono Takashi
Published: August 2024

This editorial comments on an article by Qu et al published in the World Journal of Gastrointestinal Oncology . It focuses on the importance of early detection of esophageal cancer, including recurrence or secondary malignancy after chemoradiotherapy (CRT). Endoscopic resection is the first choice for treatment for esophageal cancer remaining within the mucous membrane, while surgery or radical CRT are treatment options for advanced stages depending on the patient’s general condition and desire. Although these treatments are potentially curative, they are more invasive than endoscopic resection. Early-stage esophageal cancer is often asymptomatic and difficult to detect. Uniform periodic endoscopy is unrealistic. Although less burdensome tests exist, including liquid biopsy and urinary biomarkers, these have not yet been widely used in clinical practice. Early detection is important after radical CRT because the local recurrence rate is higher than that after surgery. However, endoscopic resection or photodynamic therapy is indicated if detected in the early stages, and positive results have been reported. Early detection of esophageal cancer is crucial. Endoscopy is the main diagnostic method; however, new and less burdensome methods should be established to ensure early treatment for patients with esophageal cancer.
Early diagnosis of esophageal cancer: How to put “early detection” into effect?
Authors: Pubu Suolang , Zhang Jun-Wen , Yang Jian
Published: August 2024

This editorial comments on the article by Qu et al in a recent edition of World Journal of Gastrointestinal Oncology , focusing on the importance of early diagnosis in managing esophageal cancer and strategies for achieving “early detection”. The five-year age-standardized net survival for esophageal cancer patients falls short of expectations. Early detection and accurate diagnosis are critical strategies for improving the treatment outcomes of esophageal cancer. While advancements in endoscopic technology have been significant, there seems to be an excessive emphasis on the latest high-end endoscopic devices and various endoscopic resection techniques. Therefore, it is imperative to redirect focus towards proactive early detection strategies for esophageal cancer, investigate the most cost-effective screening methods suitable for different regions, and persistently explore practical solutions to improve the five-year survival rate of patients with esophageal cancer.
Colon cancer screening: What to choose?
Authors: Gomez Zuleta Martin Alonso
Published: August 2024

Colorectal cancer is one of the predominant tumors in the world, primarily generated by a progression from polyp to cancer which can last several years, giving a great opportunity to the scientific community for its prevention by screening programs that can be done with invasive and non-invasive tests. In this issue, Lopes et al show us an excellent review of screening, its options, its advantages and disadvantages.
Research progress on the development of hepatocyte growth factor/c-Met signaling pathway in gastric cancer: A review
Authors: Wei Wu-Jie , Hong Ya-Li , Deng Yi , Wang Guan-Liang , Qiu Jiang-Tao , Pan Fang
Published: August 2024

Hepatocyte growth factor (HGF) and its receptor, c-Met, play important roles in the occurrence, development, and treatment of gastric cancer (GC). This review explored the function of the HGF/c-Met signaling pathway in GC and its potential targeted therapeutic mechanisms. As one of the most common malignant tumors worldwide, GC has a complex pathogenesis and limited therapeutic options. Therefore, a thorough understanding of the molecular mechanism of GC is very important for the development of new therapeutic methods. The HGF/c-Met signaling pathway plays an important role in the proliferation, migration, and invasion of GC cells and has become a new therapeutic target. This review summarizes the current research progress on the role of HGF/c-Met in GC and discusses targeted therapeutic strategies targeting this signaling pathway, providing new ideas and directions for the treatment of GC.
Serum ferritin and the risk of early-onset colorectal cancer
Authors: Urback Adam L , Martens Kylee , McMurry Hannah Stowe , Chen Emerson Y , Citti Caitlin , Sharma Anil , Kardosh Adel , Shatzel Joseph J
Published: August 2024

BACKGROUND

The incidence of early-onset colorectal cancer (EO-CRC) is rising in the United States, and is often diagnosed at advanced stages. Low serum ferritin is often incidentally discovered in young adults, however, the indication for endoscopy in EO-CRC is unclear.

AIM

To compare serum ferritin between patients with EO-CRC and healthy controls (HCs), and examine the association of serum ferritin in EO-CRC with patient- and disease-specific characteristics.

METHODS

A retrospective study of patients < 50 years with newly-diagnosed EO-CRC was conducted from 1/2013-12/2023. Patients were included if serum ferritin was measured within 2 years prior to 1 year following CRC histologic diagnosis. To supplement the analysis, a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison. A sensitivity analysis including only patients with serum ferritin obtained at or before diagnosis was separately performed to minimize risk of confounding.

RESULTS

Among 85 patients identified with EO-CRC (48 females), the median serum ferritin level was 26 ng/mL (range < 1-2759 ng/mL). Compared to HCs (n = 80211), there were a higher proportion of individuals with EO-CRC with serum ferritin < 20 ng/mL (female 65%, male 40%) versus HCs (female 32.1%, male 7.2%) age 29-39 years (P = 0.002 and P < 0.00001, respectively). Stage IV disease was associated with significantly higher serum ferritin compared to less advanced stages (P < 0.001). Serum ferritin obtained before or at the time of diagnosis was lower than levels obtained after diagnosis. Similar findings were confirmed in the sensitivity analysis.

CONCLUSION

Severe iron deficiency may indicate an increased risk of EO-CRC, particularly at earlier stages. Further studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.
Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1
Authors: Kang Shin Woo , Lim Sung Hee , Kim Min-Ji , Lee Jeeyun , Park Young Suk , Lim Ho Yeong , Kang Won Ki , Kim Seung Tae
Published: August 2024

BACKGROUND

Bevacizumab, an anti-vascular endothelial growth factor (VEGF) monoclonal antibody, inhibits angiogenesis and reduces tumor growth. Serum VEGF-C, lactate dehydrogenase, and inflammatory markers have been reported as predictive markers related to bevacizumab treatment. Programmed cell death ligand 1 (PD-L1) could act upon VEGF receptor 2 to induce cancer cell angiogenesis and metastasis.

AIM

To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer (CRC) according to the expression of PD-L1.

METHODS

This analysis included CRC patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24, 2014 and February 28, 2022, at Samsung Medical Center (Seoul, South Korea). Analysis of patient data included evaluation of PD-L1 expression by the combined positive score (CPS). We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with CRC.

RESULTS

A total of 124 patients was included in this analysis. Almost all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line chemotherapy. While 77% of patients received FOLFOX, 23% received FOLFIRI as backbone first-line chemotherapy. The numbers of patients with a PD-L1 CPS of 1 or more, 5 or more, or 10 or more were 105 (85%), 64 (52%), and 32 (26%), respectively. The results showed no significant difference in progression-free survival (PFS) and overall survival (OS) with bevacizumab treatment between patients with PD-L1 CPS less than 1 and those with PD-L1 CPS of 1 or more (PD-L1 < 1% vs PD-L1 ≥ 1%; PFS: P = 0.93, OS: P = 0.33), between patients with PD-L1 CPS less than 5 and of 5 or more (PD-L1 < 5% vs PD-L1 ≥ 5%; PFS: P = 0.409, OS: P = 0.746), and between patients with PD-L1 CPS less than 10 and of 10 or more (PD-L1 < 10% vs PD-L1 ≥ 10%; PFS: P = 0.529, OS: P = 0.568).

CONCLUSION

Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-L1 expression.
Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer
Authors: Zhang Li-Xiang , Luo Pan-Quan , Wei Zhi-Jian , Xu A-Man , Guo Tao
Published: August 2024

BACKGROUND

Gastric cancer (GC) is a common malignant tumor, long non-coding RNA and microRNA (miRNA) are important regulators that affect tumor proliferation, metastasis and chemotherapy resistance, and thus participate in tumor progression. CASC19 is a new bio-marker which can promote tumor invasion and metastasis. However, the mechanism by which CASC19 affects the progression of GC through miRNA is not clear.

AIM

To explore the role of the CASC19/miR-491-5p/HMGA2 regulatory axis in GC.

METHODS

To explore the expression and prognosis of CASC19 in GC through clinical samples, and investigate the effects of inhibiting CASC19 on the proliferation, migration, invasion and other functions of GC cells through cell counting Kit-8 (CCK-8), ethynyldeoxyuridine, Wound healing assay, Transwell, Western blot and flow cytometry experiments. The effect of miR-491-5p and HMGA2 in GC were also proved. The regulatory relationship between CASC19 and miR-491-5p, miR-491-5p and HMGA2 were validated through Dual-luciferase reporter gene assay and reverse transcription PCR. Then CCK-8, Transwell, Wound healing assay, flow cytometry and animal experiments verify the role of CASC19/miR-491-5p/HMGA2 regulatory axis.

RESULTS

The expression level of CASC19 is related to the T stage, N stage, and tumor size of patients. Knockdown of the expression of CASC19 can inhibit the ability of proliferation, migration, invasion and EMT conversion of GC cells, and knocking down the expression of CASC19 can promote the apoptosis of GC cells. Increasing the expression of miR-491-5p can inhibit the proliferation of GC cells, miR-491-5p mimics can inhibit EMT conversion, and promote the apoptosis of GC cells, while decreasing the expression of miR-491-5p can promote the proliferation and EMT conversion and inhibit the apoptosis of GC cells. The expression of HMGA2 in GC tissues is higher than that in adjacent tissues. At the same time, the expression level of HMGA2 is related to the N and T stages of the patients. Reducing the level of HMGA2 can promote cell apoptosis and inhibit the proliferation of GC cells. Cell experiments and animal experiments have proved that CASC19 can regulates the expression of HMGA2 through miR-491-5p, thereby affecting the biological functions of GC.

CONCLUSION

CASC19 regulates the expression of HMGA2 through miR-491-5p to affect the development of GC. This axis may serve as a potential biomarker and therapeutic target of GC.
Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum
Authors: Yin Li-Li , Qi Ping-Qian , Hu Yun-Fei , Fu Xiao-Jun , He Rui-Shan , Wang Meng-Meng , Deng Yan-Juan , Xiong Su-Yi , Yu Qi-Wen , Hu Jin-Ping , Zhou Lv , Zhou Zhi-Bin , Xiong Ying , Deng Huan
Published: August 2024

BACKGROUND

Colorectal polyps, which are characterized by a high recurrence rate, represent preneoplastic conditions of the intestine. Due to unclear mechanisms of pathogenesis, first-line therapies for non-hereditary recurrent colorectal polyps are limited to endoscopic resection. Although recent studies suggest a mechanistic link between intestinal dysbiosis and polyps, the exact compositions and roles of bacteria in the mucosa around the lesions, rather than feces, remain unsettled.

AIM

To clarify the composition and diversity of bacteria in the mucosa surrounding or 10 cm distal to recurrent intestinal polyps.

METHODS

Mucosal samples were collected from four patients consistently with adenomatous polyps (Ade), seven consistently with non-Ade (Pol), ten with current Pol but previous Ade, and six healthy individuals, and bacterial patterns were evaluated by 16S rDNA sequencing. Linear discriminant analysis and Student’s t -tests were used to identify the genus-level bacteria differences between groups with different colorectal polyp phenotypes. Pearson’s correlation coefficients were used to evaluate the correlation between intestinal bacteria at the genus level and clinical indicators.

RESULTS

The results confirmed a decreased level of probiotics and an enrichment of pathogenic bacteria in patients with all types of polyps compared to healthy individuals. These changes were not restricted to the mucosa within 0.5 cm adjacent to the polyps, but also existed in histologically normal tissue 10 cm distal from the lesions. Significant differences in bacterial diversity were observed in the mucosa from individuals with normal conditions, Pol, and Ade. Increased abundance of Gram-negative bacteria, including Klebsiella , Plesiomonas , and Cronobacter , was observed in Pol group and Ade group, suggesting that resistance to antibiotics may be one risk factor for bacterium-related harmful environment. Meanwhile, age and gender were linked to bacteria changes, indicating the potential involvement of sex hormones.

CONCLUSION

These preliminary results support intestinal dysbiosis as an important risk factor for recurrent polyps, especially adenoma. Targeting specific pathogenic bacteria may attenuate the recurrence of polyps.
Current trends and hotspots of depressive disorders with colorectal cancer: A bibliometric and visual study
Authors: Yan Zi-Wei , Liu Ying-Nan , Xu Qian , Yuan Yuan
Published: August 2024

BACKGROUND

Depression is strongly associated with colorectal cancer (CRC). Few bibliometric analyses have systematically summarized the research focus and recent progress in this field.

AIM

To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and depression.

METHODS

Articles on depression in CRC patients were collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to visualize bibliometric networks.

RESULTS

From 2001 to 2022, Supportive Care in Cancer , the United States, Tilburg University, and Mols were the most productive and influential journal, country, institution, and author name. Co-occurrence cluster analysis of keywords placed quality of life, anxiety, and psychological stress in the center of the visual network diagram. Further clustering was performed for the clusters with studies of the relevant mechanism of action, which showed that: (1) Cytokines have a role essential for the occurrence and development of depressive disorders in CRC; (2) MicroRNAs have a role essential for the development of depressive disorders in CRC; (3) Some anticancer drugs have pro-depressant activity; and (4) Selective serotonin reuptake inhibitors have both antitumor and antidepressant activity.

CONCLUSION

Life quality and psychological nursing of the cancer population were key topics. The roles of cytokines and microRNAs, the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.
Predictors of Resolution of Meningitis Symptoms in Tuberculous Meningitis: A Clinical, Magnetic Resonance Imaging, and Biomarker Study
Authors: Pandey Prakash C. , Kalita Jayantee , Shukla Ruchi
Published: August 2024

In tuberculous meningitis (TBM), the meningeal symptoms and their resolution after treatment may be dependent on clinical-radiological severity, cerebrospinal fluid (CSF), and proinflammatory cytokines, and these findings may be associated with outcome. There is a paucity of studies on the resolution of meningitis symptoms in TBM. We report on associations of clinical, magnetic resonance imaging (MRI), laboratory, and proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin 6 (IL-6)] findings with the resolution of meningitis symptoms (RMS), and the impact of RMS duration on the outcome in TBM. Seventy-one patients with TBM were included, and their clinical, laboratory, and MRI findings at baseline were recorded. mRNA profiling of TNF-α and IL-6 was done by reverse transcriptase polymerase chain reaction. The day of RMS (fever, headache, and vomiting) after treatment was noted. Predictors of long duration of RMS (>3 weeks) were evaluated by univariate followed by multivariate analysis. The impact of RMS on 6-month mortality and outcome was analyzed. Patients’ median age was 25 years, and 45 (63.4%) were males. After antitubercular treatment, meningeal symptoms resolved in 35 (50.70%) by 21 days and in 90% of patients by 49 days. Longer time of RMS was associated with TBM stage, pretreatment duration, seizure, and hydrocephalus but not with TNF-α and IL-6. Seven (9.8%) patients died at 6 months, and duration of RMS predicted death (hazard ratio = 25.55, 95% CI: 1.108–589.40; P = 0.04).
PENGARUH LATAR BELAKANG PENDIDIKAN ORANG TUA TERHADAP SIKAP TOLERANSI ANTAR-AGAMA, TOLERANSI ANTAR SUKU, DAN TOLERANSI SESAMA AGAMA PADA MAHASISWA
Authors: Djamaluddin Mawardi , Eku Amran , Arifin Asriyani M
Published: August 2024

Rendahnya sikap keterbukaan seseorang dalam menerima perilaku dan keyakinan yang berbeda dari walaupun orang tersebut tidak setuju dengan apa yang dilakukan oleh lain telah berampak pada kedewasaan dalam berinteraksi dengan orang lain terutama berkaitan dengan kemampuan dalam memecahkan mahasalah dalam menghadapi sudut pandang yang berbeda. Penelitian ini secara umum bertujuan untuk melihat Pengaruh latarbelakang pekeraan orang tua terhadap sikap toleransi antar-agama, toleransi antar suku, dan toleransi sesama agama pada Mahasiswa IAIN Ternate. Menggunakan jenis penelitian komparatif dalam penelitian kuantitatif, data dikumpulkan menggunakan tiga instumen yang berbeda, yaitu skala Toleransi Antar Agama, skala Toleransi Antar Budaya, dan skala toleransi sesama Agama. Teknik analisis data yang digunakan adalah analisis deskriptif dan analisis multivariat MANOVA (Multi-variate Analysis of Variansce). Populasi penelitian adalah mahasiswa IAIN Ternate dengan menggunakan teknik sampling yaitu stratified sampling sehingga subjek penelitian dibagi kedalam tiga karakteritistik spesifik terkait dengan latar belakang pendidikan orang tua. Hasil penelitian menunjukkan bahwa 1) perbedaan nilai Toleransi Antar Agama berdasarkan latar belakang pendidikan, yang memiliki perbedaan adalah Sekolah Menengah Atas dengan S1, Ssekolah Menengah Atas dengan S2, dan S1 dengan S2; 2) perbedaan nilai Toleransi Antar budaya berdasarkan latar belakang pendidikan, yang memiliki perbedaan adalah Sekolah Menengah Atas dengan S1, Sekolah Menengah Atas dengan S2, dan S2 dengan S1; dan 3) perbedaan nilai Toleransi sesama Agama berdasarkan latar belakang pendidikan, yang memiliki perbedaan adalah Sekolah Menengah Atas dengan S1, S2 dengan Sekolah Menengah Atas, dan S2 dengan S1. Sikap toleransi yang dimiliki oleh individu sangat dipengaruhi oleh latar belakang pendidikan yang dimiliki oleh orang tua karena pola pendidikan yang diberikan kepada individu dapat membentuk pengalaman individu dalam menilai dan memberikan persepsi kepada orang lainnya yang bebeda dengannya.
Epigallokateşin Gallatın (EGCG) Parkinson Hastalığı Patogenezinde Potansiyel Koruyucu Etkileri
Authors: Yıldız Elif , Yıldırım İlknur Gökçe
Published: August 2024

Bu derlemenin amacı, epigallokateşin gallatın Parkinson hastalığı patogenezi üzerindeki koruyucu etkilerini incelemektir. Son yıllarda yapılan epidemiyolojik çalışmalarda Parkinson hastalığının artış gösterdiği ve son 25 yılda ikiye katlandığı vurgulanmaktadır. Bundan dolayı hastalığın patogenezine etki edebilen faktörleri değerlendirmek önem kazanmaktadır. Yapılan çalışmalarda vücutta meydana gelen oksidatif stres, inflamasyon ve α-sinüklein proteinin anormal agregasyonu gibi faktörlerin Parkinson’un patogenezinde rol oynadığı saptanmıştır. Çay bileşenlerinden epigallokateşin gallat antiinflamatuar özelliği, oksidatif stres ve α-sinüklein kaynaklı hasara karşı koruyucu etkisi ile Parkinson’un patogeneziyle ilişkili olabilmektedir. Sonuç olarak, epigallokateşin gallatın Parkinson üzerindeki koruyucu etkisine yönelik klinik araştırmalar azdır. Gelecek araştırmalarda daha fazla kanıta dayalı klinik çalışmalarla epigallokateşin gallatın Parkinson üzerindeki etkinliği değerlendirilebilir.
Távol és mégis közel. Kincses Elemér 1977-es „Don Carlos”-rendezése
Authors:   Theatre and Multimedia Research Institute, University of Arts, Târgu-Mureș, György Andrea
Published: August 2024

On December 30, 1977, Schiller’s “Don Carlos” was presented by the Hungarian Department of State Theatre in Târgu-Mureș. Elemér Kincses, a newly graduated young director gave a modern interpretation on the well-known play. He also developed a special relationship with the dramatical text, as he himself declared in the programme-booklet of the performance: „Schiller’s brilliant work is almost or totally incomprehensible at first sight. It is like a gothic cathedral: while I am standing inside it, I can see only the details. To perceive all its beauty, I must move away from it. If I move away, the beauty of the details is lost. So, to be far away and yet close, this is the task”. By the analysis and the reconstruction of the performance, I seek to answer why is considered canon forming this outstanding achievement of Kincses’s directorial career.
Análisis contrastivo de la naturaleza categorial de las formas verbales no finitas en español y en inglés
Authors: Álvarez Marina
Published: August 2024

Las formas no finitas se constituyen en un enigma que generan cierta dificultad en la enseñanza del español y el inglés como lenguas extranjeras y, sin dudas, representan un desafío para la traductología. Por eso, un estudio en profundidad puede significar un aporte para disciplinas como la didáctica de la gramática y de la traducción. Bajo un enfoque cognitivo funcional, partimos de premisas que nos permiten observar el lenguaje como una capacidad que forma parte de la cognición en general y que explora facultades cognitivas como la percepción, la conceptualización, la categorización, y la memoria, entre otras, que, a su vez, ponen en funcionamiento una serie de mecanismos como la gramaticalización o la construccionalización que dan lugar a las explicaciones lingüísticas que pretendemos alcanzar con esta investigación. Para ello, se parte del análisis del lenguaje en uso, con un cuerpo de datos original que no pretende ser exhaustivo sino representativo de la variedad de empleos en los que intervienen las formas no finitas. Los objetivos generales de esta investigación han sido: dar cuenta de la naturaleza categorial de las formas no finitas del verbo en español y en inglés; realizar una comparación transparente y sistemática de los infinitivos, gerundios y participios del español y del inglés en tanto categorías híbridas (Bosque, 1999, 2014), dado que, por un lado, conservan la valencia verbal que los habilita a conformar cláusulas predicativas reducidas, y, por otro, ocupan posiciones sintácticas típicas de otras clases de palabras o proposiciones (Kovacci, 1992) del tipo nominal, adjetival o adverbial; y así concretar un aporte preciso en el campo de la Lingüística Aplicada que colabore en la resolución de disyuntivas que surjan de la traducción de formas no finitas.
Guimerà: la persistència d’un mite popular i els debats al voltant del cinquantenari de la seva mort (1909–1974)
Authors: Cattini Giovanni C.
Published: August 2024

Few authors are able to represent and exemplify in life the continuity between national literary canon and territorial identity as well as Àngel Guimerà i Jorge (1845–1924). This article sets out to trace the continuities and permanence in Catalan culture of the figure of Guimerà, but at the same to highlight the contrasting or contradictory elements that have characterized public evaluations of his legacy. Beginning with brief consideration of the monumentalization of Guimerà in the early 20th century and immediately following his death in 1924, we will go on to focus on debates around his significance towards the end of the Franco dictatorship, as it was then that new generations of intellectuals and artists who had not directly experienced the civil war would consider the continuing relevance or validity of his writings. This process culminated in 1974 on the occasion of the fiftieth anniversary of his death: when there was open debate in the press about the place of Guimerà in Catalan culture, and, more specifically, on the Catalan stage. Here we aim to contextualise these debates, elucidating both the challenges presented by different aspects of his figure and work for recovery in the Catalan society of the period and the light they shed on the ways in which literary figures are resignified over time.
El culte als 'homes de lletres' i els seus usos a la Catalunya del Vuit-cents: els casos de Jaume Balmes i Antoni de Capmany
Authors: Roca Vernet Jordi , Cao-Costoya David
Published: August 2024

This paper analyses the main displays of posthumous cults of commemoration for the figures of Jaume Balmes and Antoni de Capmany that took place in Catalonia between approximately 1848 and 1891. Inscribing these tribute initiatives in the wider scholarship on the political uses of death and the public celebration of great men, we identify them as turning points in the cultural practice of public commemorations dedicated to writers, artists and intellectuals. Balmes and Capmany were erected as collective reference points by a significant segment of the Catalan ruling classes who were in some way attached to the liberal regime. In doing so, they sought to provide themselves with prestigious cohesive symbols for a society they wished to distance both from reactionary positions and from revolutionary popular mobilisation. Through the symbolic figures of Balmes and Capmany, the promoters of these commemorative cults were able to shore up their own reputation and claim a leading role within the Spanish nation for the local and regional areas in which they were active.
Abuso del Incidente de Reinstalación Laboral por Simulación de Contrato en la Jurisprudencia Constitucional
Authors: Prado Mendía Gerardo Andrés
Published: August 2024

PROBLEMA: El problema surge del abuso de la jurisprudencia constitucional al permitir abordar la simulación laboral a través de un incidente de reinstalación, contradiciendo el artículo 380 del Código de Trabajo que prohíbe prejuzgar sobre despidos. OBJETIVO: Analizar el abuso del incidente de reinstalación laboral por simulación de contrato en la jurisprudencia constitucional para establecer las tendencias de la Corte de Constitucionalidad de Guatemala en materia de interpretación de los derechos laborales. MÉTODO: Estudio de casos mediante análisis de tres sentencias de la Corte de Constitucionalidad. RESULTADOS: La Corte de Constitucionalidad resalta la importancia de identificar relaciones laborales genuinas, incluso cuando se intenta disfrazar la temporalidad bajo contratos a plazo fijo. Se subraya la responsabilidad de los jueces en detectar simulaciones contractuales y la necesidad de autorización judicial previa en casos de terminación laboral en contextos de conflicto colectivo, con la posibilidad de reinstalación del trabajador despedido como consecuencia del incumplimiento de los artículos 379 y 380 del Código de Trabajo. CONCLUSIÓN: La Corte de Constitucionalidad está excediendo su poder al ordenar reinstalaciones laborales sin seguir el procedimiento establecido en el Código de Trabajo. Esto desencadena una invasión de competencias y una modificación del proceso laboral sin respaldo normativo, socavando la separación de poderes y la legalidad en la resolución de conflictos laborales.
TANTANGAN DAN SOLUSI PENERAPAN SISTEM INFORMASI AKUNTANSI DI INDONESIA: SEBUAH ANALISIS TEMATIK
Authors: Hilia Anriva Della
Published: August 2024

This research aims to investigate the benefits, obstacles and recommendations for implementing Accounting Information Systems (AIS) in Indonesia. The research method used is qualitative, with data sources from scientific documents such as journals and thematic analysis using NVivo 12 Plus software. This study outlines some of the critical benefits of AIS, including improved operational efficiency, data accuracy, transparency, decision support, and regulatory compliance. However, various barriers were also identified, such as limited technological infrastructure, changes in organizational culture and processes, data security, lack of management understanding and support, and implementation and training costs. Recommendations to overcome these barriers include increasing understanding and awareness of AIS, evaluating technology infrastructure, employee training, and collaboration with professional service providers. These findings highlight the need for better awareness of the benefits of AIS, improved technological infrastructure, employee training, and management support as critical factors in the successful implementation of AIS in Indonesia. Further research is recommended to conduct field studies through interviews and observations to gain deeper insight into the challenges and needs in implementing AIS in Indonesia.
Diabetes tipo 2 em crianças e adolescentes: revisão da literatura
Authors: Almeida Giovanna Sales Nogueira , Freitas Beatriz Moreira Motta de , Nascimento Aline Faggion Araújo
Published: August 2024

O diabetes tipo 2, tradicionalmente associado a adultos, tem apresentado uma crescente prevalência entre crianças e adolescentes. Esta revisão sistemática da literatura visa explorar as causas, consequências e abordagens terapêuticas para o diabetes tipo 2 nessa faixa etária. A análise abrange estudos publicados entre 2010 e 2023, destacando fatores de risco, manifestações clínicas, complicações e estratégias de manejo. A revisão evidencia a necessidade de intervenções precoces e integradas, envolvendo educação, mudanças no estilo de vida e tratamentos farmacológicos para mitigar o impacto desta condição em jovens.
Síndrome de Frey: uma revisão de literatura
Authors: Scaff José Elias Rodrigues Souza , Gomes Ana Karolina , Siqueira Luciana Dorneles , Matheus Larissa Fabiana Costa
Published: August 2024

A Síndrome de Frey, também conhecida como hiperidrose gustativa, é uma condição neurológica caracterizada pela transpiração e rubor na região pré-auricular após estímulos gustativos. Esta revisão sistemática visa compilar e analisar as publicações mais relevantes sobre a Síndrome de Frey, com enfoque em sua fisiopatologia, diagnóstico, manejo clínico e opções terapêuticas. A metodologia incluiu a busca em bases de dados como PubMed, SciELO e LILACS, com seleção de artigos publicados em português e inglês. Os resultados apontam para a diversidade de abordagens diagnósticas e terapêuticas, bem como para a necessidade de maior padronização nos critérios de diagnóstico e avaliação de resultados. Conclui-se que a Síndrome de Frey, embora rara, demanda uma abordagem multidisciplinar.
Neurofibromatose tipo 1 na infância: uma revisão da literatura
Authors: Sá Jana Lopes de , Pontes Júlia Freire , Oliveira Isadora Dacielle Fortunato de
Published: August 2024

A neurofibromatose tipo 1 (NF1) é uma doença genética autossômica dominante que se manifesta frequentemente na infância. Caracterizada por uma ampla variedade de sinais clínicos, a NF1 pode afetar múltiplos sistemas orgânicos, levando a complicações neurológicas, dermatológicas e ortopédicas, entre outras. Este estudo realiza uma revisão sistemática da literatura sobre a apresentação clínica, diagnóstico, manejo e prognóstico da NF1 em crianças. Foram analisados artigos publicados nas principais bases de dados médicas, com foco em estudos brasileiros para contextualizar a realidade nacional. Os resultados mostram a importância de um diagnóstico precoce e de um acompanhamento multidisciplinar para melhorar a qualidade de vida dos pacientes. Conclui-se que, apesar dos avanços no entendimento da NF1, há necessidade de mais pesquisas para otimizar o tratamento e o manejo dessa condição.
Efeitos fisiológicos sobre o comportamento alimentar de adolescentes: uma revisão de literatura
Authors: Lima Joseilson Araújo de Oliveira , Martins Nicole Rodrigues , Cunha Rosana Borges da , Rodrigues Leandro da Cunha , Ávilla Ingrid Jayme
Published: August 2024

Este artigo revisa sistematicamente a literatura sobre os efeitos fisiológicos no comportamento alimentar de adolescentes. A adolescência é um período crítico de desenvolvimento que envolve mudanças fisiológicas significativas, afetando diretamente o comportamento alimentar. Identificamos e analisamos estudos brasileiros para entender como essas mudanças influenciam a alimentação. Foram incluídos estudos relevantes dos últimos dez anos. Os resultados indicam que fatores como alterações hormonais, crescimento acelerado e influências neurobiológicas têm um impacto substancial sobre os hábitos alimentares dos adolescentes. Concluímos que uma abordagem multidisciplinar é necessária para abordar as complexas interações entre fisiologia e comportamento alimentar nesta faixa etária.
Síndrome ocular isquêmica simulando retinopatia diabética unilateral: relato de caso e revisão da literatura
Authors: Cavalheiro Lucas Thomé , Lima Gabriela Elenor dos Santos , Bizinotto Gabriel Bahia Arantes
Published: August 2024

A síndrome ocular isquêmica (SOI) é uma condição rara, caracterizada pela redução do fluxo sanguíneo ocular, frequentemente secundária a estenose ou oclusão da artéria carótida interna. A apresentação clínica pode mimetizar outras doenças oculares, como a retinopatia diabética (RD), especialmente em casos unilaterais. Este artigo apresenta um relato de caso de SOI simulando RD unilateral e realiza uma revisão sistemática da literatura, destacando os principais achados clínicos, diagnósticos diferenciais e abordagens terapêuticas. O objetivo é aumentar a conscientização sobre essa condição e melhorar o diagnóstico diferencial na prática clínica oftalmológica.
Retinopatia pigmentar devido a Síndrome de Bardet-Biedl: relato de caso e revisão de literatura
Authors: Sousa Isaías Filipe Assunção de , Campos Júnior Crispim Elias , Almeida Emilia Gama de , Silva Caio Elias Palasios
Published: August 2024

A Síndrome de Bardet-Biedl (BBS) é uma doença genética rara caracterizada por múltiplos sintomas, incluindo a retinopatia pigmentar (RP). Este artigo apresenta um relato de caso de um paciente diagnosticado com BBS, que manifestou RP, e realiza uma revisão sistemática da literatura sobre as características clínicas, genéticas e abordagens terapêuticas da RP associada à BBS. A revisão incluiu artigos científicos publicados em bases de dados nacionais e internacionais. Os resultados evidenciam a importância do diagnóstico precoce e do acompanhamento multidisciplinar para o manejo adequado da RP em pacientes com BBS.
Macroinvertebrate Community as Bioindicator of Water Quality of Tambis River, Palompon, Leyte, Philippines
Authors:   Visayas State University, Igloria Joenabeth , Seriño Eunice Kenee , Magbanua Francis , Mazo Analyn , Pogado Fretzeljane
Published: August 2024

Macroinvertebrates have been used globally as bioindicators of water quality of rivers due to their varying tolerance to pollution. The water quality of Tambis River in Palompon, Leyte, Philippines was determined using macroinvertebrates and selected physico-chemical and ecological assessments. Employing kick-sampling method, three sampling stations were established based on the surrounding land use (forested, agricultural, and near residential). Twenty-seven macroinvertebrate families were identified. Permutational multivariate analysis of variance (PERMANOVA) revealed a significant difference in the benthic macroinvertebrate families across three stations (p=0.001). There was a decrease in the abundance of pollution-sensitive families from the forested station towards the downstream, closest to the residential area. Sensitive Ephemerellidae and tolerant Thiaridae were the most abundant in the forested and downstream area respectively. The highest diversity and evenness were observed from the agricultural area. Stream Invertebrate Grade Number - Average Level (SIGNAL 2) scores were plotted declined in all quadrants, suggesting good water quality to moderately polluted. Water temperature, pH, and velocity were the most influencing environmental variables to the macroinvertebrate assemblage as revealed by the Canonical Correspondence Analysis (CCA). Overall, the water quality of Tambis River ranged from being of good quality to moderately polluted. The data obtained in this study could serve as a baseline in providing information to formulate and implement scientific-based regulatory measures towards the conservation of Tambis River.
The Effect of Solvency Ratio and Profitability on The Financial Performance of PT Charoen Pokphand Indonesia Tbk
Authors: Aprilyani Tanti , Hidayat Rahmat , Kusworo Ahmad Dzulfikri Budi
Published: August 2024

The purpose of this study is to effect solvency ratio and profitability on financial performance of PT Charoen Pokphand Indonesia Tbk. Descriptive research using a qualitative approach is the type of research used in this study. Based on the results of the study, the financial performance of PT Charoen Pokphand Indonesia Tbk during the period 2021 to 2023 illustrates extraordinary achievements in terms of profitability, efficiency of asset use, and debt management. During the period, the company managed to increase its net profit margin from 10% to 40%, indicating excellent financial performance. Return on Assets (ROA) increased from 7% to 34%, indicating improved efficiency in asset use. The suggestion proposed is to continue to monitor and improve the efficiency of asset use, as well as consider investments that can increase asset returns. Return on Equity (ROE) also experienced a significant increase from 8% to 42%, demonstrating the company's ability to generate high returns on equity.
Prediksi Produksi Rokok Klobot Menggunakan Metode Logika Fuzzy Mamdani
Authors: Al-Faruq Rizqi Noval , Hindarto Hindarto
Published: August 2024

Penelitian ini mengeksplorasi penerapan metode Mamdani dalam logika fuzzy untuk pengambilan keputusan terkait jumlah produksi di Pabrik Rokok CV Oeloeng, Bojonegoro. Melibatkan perencanaan, pabrik ini mengandalkan logika fuzzy untuk menghitung produksi dalam suatu periode, mengatasi ketidakpastian dari sisa persediaan sebelumnya dan estimasi penjualan yang tidak pasti. Dengan mengidentifikasi variabel-variabel melalui tahapan fuzzyfikasi, aplikasi simplikasi, aturan, dan defuzzyfikasi, metode ini diimplementasikan dengan merujuk pada data penjualan dan persediaan dari Agustus 2022 hingga Juli 2023. Hasilnya memproyeksikan produksi rokok klobot sebesar 4120 stang, dengan penjualan 4700 stang dan persediaan gudang 2800 stang, dengan tingkat keakuratan 73,17%. Hasil ini dapat dianggap cukup memadai untuk mendukung pengambilan keputusan terkait produksi.
Perancangan Sistem Informasi Sekolah Berbasis Web Menggunakan Metode SDLC
Authors: Dewa Suma Bayunda Amartya , Azizah Nuril Lutvi
Published: August 2024

: Pentingnya pengembangan sistem informasi, terutama dalam konteks pendidikan, semakin meningkat sejalan dengan perkembangan zaman. Di TK ABA 8 CANDI Sidodadi, pengelolaan data siswa masih dilakukan secara manual, dan informasi terkait sekolah serta Penerimaan Peserta Didik Baru (PPDB) hanya disampaikan melalui media sosial tanpa adanya integrasi sistem informasi. Dalam penelitian ini, dirancang sebuah sistem informasi sekolah berbasis website untuk TK ABA 8 CANDI. Sistem ini diharapkan dapat memberikan dukungan yang signifikan kepada guru dan pengurus sekolah, khususnya dalam proses penyampaian informasi sekolah. Pelatihan penggunaan sistem informasi ini menjadi penting, karena keberhasilannya sangat tergantung pada pemahaman yang baik dari para pengguna. Sistem ini juga diharapkan dapat mengoptimalkan proses pendataan siswa, mengurangi waktu dan tenaga yang biasanya dibutuhkan. Fitur seperti visi & misi, profil, penerimaan peserta didik baru, dan kontak sekolah, dan sistem pendataan siswa, diharapkan dapat mendukung kegiatan administrasi sekolah dan menyediakan informasi yang komprehensif kepada masyarakat tentang TK ABA 8 CANDI.
Sistem Informasi Inventory dengan Notifikasi Bot Telegram Berbasis Website (Studi Kasus PT. Global Data Akses
Authors: Syafaat Dany , Fitrani Arif Senja
Published: August 2024

: PT. Global Data Akses Persada atau GDAP adalah sebuah perusahaan yang bergerak pada bidang Internet Service Provider (ISP), yang berfokus pada bidang penyediaan Produk dan Jasa untuk berbagai kebutuhan IT. Dalam proses bisnis pendataan inventory barangnya yang masih menggunakan cara manual hal ini yang sering menimbulkan selisih jumlah pada saat di audit , belum adanya sistem inventory yang digunakan untuk mengelola data inventory tersebut serta memberikan notifikasi barang mana saja yang perlu di restock kembali adalah permasalahannya , maka dari itu penulis berusaha memberikan solusi sebuah sistem informasi inventory dengan notifikasi bottelegram berbasis website yang diusahakan lebih mobile friendly untuk kebutuhan pendataan inventory barang pada perusahaan. Pada sistem inventory ini akan dibangun dengan menggunakan berbasis webisite PHP , Mysql, dan Codeigniter dimana juga akan terkoneksi dengan menggunakan bot telegram sebagai pengirim notifikasi jumlah stok barang yang ada pada gudang, sehingga akan lebih praktis dan informatif serta mudah di ketahui oleh staff perusahaan jumlah stok barang.
Penerapan Augmented Reality dalam Pendidikan Anatomi Manusia di Sekolah Menengah
Authors: Lorin Emelin Yuan , Hindarto Hindarto , Taurusta Cindy
Published: August 2024

: Penelitian ini membahas mengenai penerapan teknologi Augmented Reality (AR) dalam pembelajaran anatomi organ vital manusia di tingkat Sekolah Menengah dengan menggunakan metode Multimedia Development Life Cycle (MDLC). Tujuan utama penelitian ini adalah untuk mengevaluasi efektivitas AR dalam meningkatkan pemahaman siswa terhadap struktur dan fungsi organ vital manusia. Melibatkan siswa Sekolah Menengah sebagai subjek penelitian, kami mengembangkan aplikasi AR berdasarkan MDLC untuk menyajikan informasi anatomi secara interaktif. Hasil penelitian menunjukkan bahwa penerapan AR secara signifikan meningkatkan pemahaman siswa terhadap anatomi organ vital. Siswa menunjukkan tingkat keterlibatan yang tinggi dan respons positif terhadap penggunaan teknologi AR dalam pembelajaran anatomi. Dengan memanfaatkan MDLC, pengembangan aplikasi AR dapat dilakukan secara terstruktur dan efisien, memastikan kualitas dan relevansi materi pembelajaran. Implikasi penelitian ini menggarisbawahi potensi AR sebagai alat pembelajaran inovatif untuk meningkatkan efektivitas pendidikan anatomi di tingkat Sekolah Menengah.
Sistem Informasi Penjualan Paket Data Berbasis Website pada UMKM Rambo Data
Authors: Endrianto Dicky Prasetyo , Sumarno Sumarno
Published: August 2024

UMKM Rambo Data, distributor nasional kredit elektronik dan paket data, beroperasi di Sidoarjo dan berkolaborasi dengan 15 mitra aktif. Berkembangnya internet telah memberdayakan pemilik bisnis untuk menggunakan situs penjualan guna meningkatkan aksesibilitas konsumen dan mempermudah transaksi, namun Rambo Data menghadapi keterbatasan dalam pemasaran dan jangkauan promosi. Penelitian ini bertujuan untuk mengembangkan situs penjualan yang lebih efektif untuk memperkuat strategi pemasaran UMKM Rambo Data. Dengan menggunakan metode coba-coba untuk pengembangan dan evaluasi situs web melalui metrik penjualan, studi ini menemukan bahwa sistem penjualan baru secara signifikan meningkatkan penjualan Rambo Data. Ini mengonfirmasi bahwa platform penjualan online yang dioptimalkan dapat secara efektif mengatasi keterbatasan pemasaran dan menarik lebih banyak pelanggan, menunjukkan bahwa alat digital sangat penting dalam meningkatkan efisiensi pemasaran untuk usaha kecil dan menengah.