bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells
Authors: Armartmuntree Napat , Kittirat Yingpinyapat , Promraksa Bundit , Loilome Watcharin , Dokduang Hasaya , Techasen Anchalee , Sansomchai Pahol , Thanee Malinee , O’Connor Thomas , Kongthitilerd Phutthida , Padthaisong Sureerat
Published: January 2025

Cholangiocarcinoma (CCA) poses a significant healthcare challenge due to the limited effects of chemotherapeutic drugs. Natural products have gained widespread attention in cancer research according to their promising anti-cancer effects with minimal adverse side effects. This study explored the potential of Tacca chantrieri (TC), a plant rich in bioactive compounds, as a therapeutic agent for CCA. TC, a traditional remedy in Southeast Asia, exhibits anti-inflammatory and cytotoxic properties against cancer cells. Ethanol extraction of TC’s rhizome was conducted, and antioxidant activities were assessed through various assays, including total phenolic and flavonoid contents, DPPH radical scavenging, and FRAP assays. The cytotoxic effects of TC extracts on CCA cell lines (KKU-213A and KKU-213C) were evaluated using MTT assays and flow cytometry. Protein levels of Bax and Bcl-2 were determined through western blot analysis. Additionally, the study investigated whether the combined impact of TC extract and cisplatin on CCA cells enhanced cisplatin’s efficacy as an anti-cancer treatment. Results indicated that ethanolic extracts from TC contained phenolic and flavonoid compounds with robust antioxidant activity. TC treatments reduce CCA cell viability, inhibiting growth and inducing apoptosis in a dose-dependent manner. The Bax/Bcl-2 ratio increases, signifying a pro-apoptotic shift. Importantly, TC extract not only decreases cell viability but also augments the inhibitory effect of cisplatin in CCA cells. These results provide valuable insights into TC’s therapeutic mechanisms and its potential to synergize with conventional chemotherapeutic agents, offering a promising avenue for the development of alternative and more effective strategies for CCA treatment.
Utilizing a novel fecal sampling method to examine resistance of the honey bee (Apis mellifera) gut microbiome to a low dose of tetracycline
Authors: Gregory Casey L. , Bradford Emma L. , Fell Richard D. , Haak David C. , Belden Lisa K.
Published: January 2025

Disruption of host-associated microbial communities can have detrimental impacts on host health. However, the capacity of individual host-associated microbial communities to resist disturbance has not been well defined. Using a novel fecal sampling method for honey bees (Apis mellifera), we examined the resistance of the honey bee gut microbiome to disruption from a low dose of the antibiotic, tetracycline (4.5 μg). Prior to the experiment, bacterial communities from fecal samples were compared to communities from dissected whole guts of the same individuals to ensure fecal samples accurately represented the gut microbiome. Fecal samples were collected from lab-caged honey bees prior to, and five days after, tetracycline exposure to assess how antibiotic disturbance affected the communities of individuals. We used metrics of alpha and beta diversity calculated from 16S rRNA gene amplicon sequences to compare gut community structure. Low dose tetracycline exposure did not consistently change honey bee gut microbiome structure, but there was individual variation in response to exposure and specific taxa (one ASV assigned to Lactobacillus kunkeei and one ASV in the genus Bombella) were differentially abundant following tetracycline treatment. To assess whether individual variation could be influenced by the presence of tetracycline resistance genes, we quantified the abundance of tet(B) and tet(M) with qPCR. The abundance of tet(M) prior to tetracycline treatment was negatively correlated with change in community membership, assessed by difference in Jaccard dissimilarity over the five-day experiment. Our results suggest that the honey bee gut microbiome has some ability to resist or recover from antibiotic-induced change, specific taxa may vary in their susceptibility to tetracycline exposure, and antibiotic resistance genes may contribute to gut microbiome resistance.
Pasteurized waste milk vs. milk replacer at the same crude protein:metabolizable energy ratio with different energy sources (fat vs. lactose) to pre-weaning Holstein calves: Effects on growth performance, feeding behavior, and health
Authors: Kargar Shahryar , Moradi Borhan , Kanani Meysam , Albenzio Marzia , Caroprese Mariangela , Zamiri Mohammad Javad , Castro Ícaro Rainyer Rodrigues de , Marcondes Marcos Inácio
Published: January 2025

The improved growth performance of calves at weaning results from an effective pre-weaning feeding strategy. The type and pasteurization process of liquid feed are among the most variable feeding practices affecting calves’ growth and health. In previous studies that compared waste milk (WM) vs. milk replacer (MR), little consideration has been given to the variations in chemical composition and feeding behavior between them, and there has been a lack of justification for the crude protein: metabolizable energy (CP:ME) ratio adopted. Hence, this study aimed to evaluate the effects of feeding pasteurized WM or MR differing in energy source (fat vs. lactose, respectively) with similar CP:ME ratio on intake, growth, feeding behavior, and health of newborn Holstein calves. Thirty-two male calves (4-d-old; 40.0 ± 0.58 kg BW) were assigned to the trial and randomly allocated to each liquid feed diet (WM or MR). Calves were housed in individual pens with free access to starter feed and fresh water. Calves were weaned on d 61 and assessed until d 101 as the postweaning period. WM-fed calves had greater total nutrient intake (DM, CP, EE, and ME), weight gain, final BW, skeletal growth parameters, and feed efficiency (d 30). Calves WM-fed sorted less against particles retained on the 2.36-mm sieve but more against particles retained on the sieve of 0.6 mm. In WM-fed calves, the sorting index decreased for feedstuff retaining on the bottom pan compared with MR-fed calves. Irrespective of the type of the liquid feed, all calves sorted for particles retaining on the sieve of 4.75 mm and the bottom pan, and against the particles that were retained on the sieves of 2.36- (MR-fed calves only), 1.18- and 0.6-mm. Starter feed nutrient intake and particle size intake from the sieves of 4.75-, 2.36-, and 1.18-mm increased in WM- vs. MR-fed calves. Eating rate and meal size but not meal frequency and length were greater in WM-fed calves, leading to higher pre- and post-weaning starter feed intake. Calves WM-fed spent less time eating and standing but more time ruminating and lying than MR-fed calves. Calves WM-fed had a lower likelihood of having elevated general appearance (score ≥2; hazard ratio = 2.79), diarrhea (score ≥3; hazard ratio = 1.35), and pneumonia (hazard ratio = 4.77). Calves WM-fed experienced shorter days with elevated general appearance, diarrhea, and pneumonia. Overall, feeding WM led to increased starter feed intake by boosting the eating rate and meal size, promoting greater growth than MR. Additionally, compared with MR, WM feeding increased time spent ruminating and lying and reduced susceptibility to diarrhea and pneumonia.
Ontology-based construction of embroidery intangible cultural heritage knowledge graph: A case study of Qingyang sachets
Authors: Liang Yan , Xie Bingxue , Tan Wei , Zhang Qiang
Published: January 2025

The fine-grained mining and construction of semantic associations within multimodal intangible cultural heritage (ICH) resources are crucial for deepening our understanding of their knowledge content and ensuring their systematic protection and transmission in the digital and intelligent era. This paper addresses the urgent need for the digital preservation and transmission of ICH resources. Following a review of current research on Qingyang sachets and ICH, the study introduces an ontology-based approach to constructing a semantic description model for the multimodal digital resources related to Qingyang sachets. By acquiring and processing multimodal resources concerning the craftsmanship and associated customs of Qingyang sachets, the study reorganizes the corresponding textual and visual knowledge. Utilizing knowledge graphs, the research explores multidimensional pathways for delivering knowledge services related to the multimodal digital resources of Qingyang sachets. Empirical research confirms the applicability and feasibility of the proposed semantic association scheme for multimodal ICH digital resources. The findings provide valuable insights for multidimensional organization and integration across scenarios, time periods, and resources within the ICH domain, offering a reference for digital solutions aimed at the systematic protection of ICH.
Non-linear dose-response relationship between uterine artery pulsatility index and risk of preeclampsia in early pregnancy: A secondary analysis based on a nested cohort study
Authors: Wang Shaou , Dong Hao
Published: January 2025

Background

Previous studies have shown that higher uterine artery pulsatility index (UtA-PI) values in early pregnancy have predictive value for the risk of preeclampsia (PE). However, the sensitivity and specificity of this marker remain controversial. This study aims to explore further the association between UtA-PI in early pregnancy and the incidence of preeclampsia.

Methods

A total of 5000 pregnant women who underwent prenatal examination and delivery at the same hospital were included in this nested cohort study. And the PI values of left and right uterine arteries of the subjects were obtained by transabdominal ultrasound using GE color doppler diagnostic device in early pregnancy (11–13 + 6 weeks), and finally the mean value of both was calculated and recorded as UtA-PI. Among them, 60 pregnant women developed preeclampsia and were randomly divided into a screening group (n = 12) and control group (n = 48) and matched with pregnant women who did not develop preeclampsia during the same period to form a subset for subsequent statistical analysis. A weighted multivariate logistic regression model was used to analyze the association between UtA-PI and PE. Additionally, the non-linear relationship between UtA-PI and the incidence of PE was examined using smooth curve fitting and a generalized additive model.

Results

After adjusting for other variables, UtA-PI values were positively correlated with the incidence of PE, and the relationship showed a non-linear U-shaped relationship (inflection point 1.83).

Conclusion

Our study showed a significantly increased risk of PE when UtA-PI exceeded 1.83. This provides a basis for clinicians to identify high-risk pregnant women early and implement timely intervention, which helps to reduce maternal and fetal complications and improve health outcomes.
História da Misericórdia de Coimbra - Volume I: 1500-1834
Authors: Lopes Maria Antónia
Published: January 2025

A obra organiza-se em 2 volumes, abarcando o 1º os anos 1500 a 1834 (fim definitivo da “Monarquia Absoluta”) e o 2º os anos 1834 a 2000, atravessando, portanto, quatro regimes políticos.
Os dois volumes apresentam a mesma estrutura, que pretende estudar todos os aspetos da instituição: “Enquadramento legal nacional e regulamentações internas”, “Irmãos, dirigentes e trabalhadores”, “Receitas, despesas e património”, “Ação social”, “Ação religiosa” e “Património artístico”.
Molecular Triggers of Non-celiac Wheat Sensitivity: A Scoping Review and Analysis
Authors: An Christine , Yang Jimin , Pinto-Sanchez M. Ines , Verdu Elena F. , Lebwohl Benjamin , Green Peter H. , Alaedini Armin
Published: January 2025

INTRODUCTION:

Nonceliac wheat sensitivity (NCWS) is characterized by a symptomatic response to the ingestion of foods containing wheat and related cereal grains in the absence of celiac disease or wheat allergy. Despite efforts to identify the constituent component(s) of wheat responsible for triggering NCWS, no consensus has emerged, leading to competing claims. We aimed to systematically evaluate the literature and provide an evidence-based conclusion on the contribution of specific wheat components to NCWS.

METHODS:

A comprehensive search of multiple bibliographic databases was conducted, focusing on primary research. Data were systematically analyzed, and methodological gaps were identified.

RESULTS:

The search identified 175 unique citations, revealing 3 categories of compounds frequently considered as potential triggers of NCWS: gluten, fermentable carbohydrates, and amylase/trypsin inhibitors (ATIs). Among 16 double-blind placebo-controlled studies, 8 reported a greater symptomatic response to gluten than the control. Only 1 controlled study examined fermentable carbohydrates, finding a modest effect, but the tested carbohydrates were not derived from wheat. No eligible studies assessed ATIs or other wheat-related compounds as potential NCWS triggers. Across studies, significant limitations and methodological inconsistencies were noted, particularly in participant selection, challenge protocols, and data reporting.

DISCUSSION:

Gluten is the most extensively investigated wheat component linked to NCWS, but evidence for its role is inconsistent and undermined by methodological limitations. No direct evidence currently links wheat fermentable carbohydrates, ATIs, or other components to NCWS symptoms. The existing evidence is insufficient to justify restricting specific components of wheat in the management of NCWS. Future studies must overcome the identified gaps to rigorously investigate the role of wheat and related cereals in NCWS, with the potential to advance diagnosis and treatment.
Satisfaction of young women with estradiol valerate/dienogest in real clinical practice in Russia: results of prospective multicenter observational study Q-SWAN
Authors: Prilepskaya V. N. , Andreeva E. N.
Published: January 2025

BACKGROUND: E2V/DNG is widely use in Russian clinical practice, although satisfaction of Russian patients and doctors has not been ever evaluated and analysed.AIM: To evaluate satisfaction in young women (18–35 years old) with a drug containing estradiol valerate/dienogest (E2V/ DNG) over a 6-month period in real clinical practice in Russia.MATERIALS AND METHODS: This was a prospective multicenter study (Q-SWAN – Qlaira, Satisfaction, WomAN [ClinicalTrials. gov: NCT04901377]) that assessed satisfaction of 504 women (average age is 27.8 years) with the contraceptive containing E2V/DNG. The characteristics of menstrual bleeding, sexual function, women’s decision to continue and satisfaction of doctors with this method of contraception were also assessed.RESULTS: It was found that 98.4% of women and 100% of doctors were “very satisfied” or “satisfied” with this method of contraception, regardless of the presence or absence of AUB. There was a significant decrease in the intensity, duration of menstrual bleeding and pain. Normalization of the parameters of the FSFI questionnaire was observed in most of the patients (89.7%). The contraceptive E2V/DNG was well tolerated by women, and the overall rate of adverse events was 7.1%. Most women (97.8%) decided to continue taking the medication after completing the study.CONCLUSION: The results of the study showed high satisfaction of young Russian women and doctors with the use of E2V/DNG, regardless of the presence or absence of AUB. The medication has a positive effect on the characteristics of bleeding/ cycle control and on the quality of sexual function, therefore, the women demonstrated a high adherence to this method of contraception.
In memory of Marianna A. Gevorkyan (January 30, 1955 - November 3, 2024)
Authors: Andreeva E. N. , Grigoryan O. R. , Mikheev R. K.
Published: January 2025

On November 3, 2024, professor of the Cathedra of Obstetrics, Gynecology and Reproductive Medicine of the Russian University of Medicine, Doctor of Medical Sciences, prominent scientist, lecturer and doctor Marianna A. Gevorkyan died at the age of 68
EFEKTIVITAS SATUAN TUGAS PENCEGAHAN DAN PENANGANAN KEKERASAN SEKSUAL UNIVERSITAS DIPONEGORO DALAM PERSPEKTIF TEORI SISTEM HUKUM LAWRENCE M. FRIEDMAN
Authors: Rofifah Salma Putri , Purwanti Ani , Indreswari Tri Laksmi
Published: January 2025

Kekerasan seksual di perguruan tinggi dapat berimplikasi pada terhambatnya akses peserta didik terhadap pendidikan yang nyaman dan tidak diskriminatif. Permendikbudristek No. 30 Tahun 2021 memandatkan pembentukan Satuan Tugas Pencegahan dan Penanganan Kekerasan Seksual (Satgas PPKS) bagi masing-masing perguruan tinggi. Universitas Diponegoro membentuk Satgas PPKS sebagai upaya strategis mendorong terciptanya lingkungan Universitas Diponegoro yang aman dari kekerasan seksual. Penelitian ini menjabarkan mengenai regulasi perlindungan hukum nasional terhadap kekerasan seksual, implementasi pembentukan serta pelaksanaan tugas dan wewenang Satgas PPKS Undip, serta menganalisis efektivitas kinerja Satgas PPKS Undip dalam tinjauan Teori Sistem Hukum Lawrence M. Friedman dengan menggunakan metode pendekatan yuridis-sosiologis. Berdasarkan hasil penelitian, ditemukan bahwa masih diperlukan evaluasi dan perbaikan untuk mendorong kinerja Satgas PPKS Undip yang efektif dan sesuai dengan ketentuan Permendikbudristek No. 30 Tahun 2021 seperti perbaikan landasan hukum Satgas PPKS Undip, optimalisasi kinerja Satgas PPKS Undip dan penyediaan fasilitas dan sarana-prasarana pendukung, serta peningkatan pengetahuan masyarakat.
IMPLIKASI HUKUM PEMBELIAN TANAH YANG AKTA JUAL BELINYA MENGGUNAKAN NAMA ORANG LAIN (STUDI DI DESA SIDOREJO KECAMATAN TIRTOMOYO KABUPATEN WONOGIRI)
Authors: Pangestu Satrio Aji , Adhim Nur , Ananingsih Sri Wahyu
Published: January 2025

Pendaftaran Tanah merupakan masalah yang sangat penting dalam UUPA, larangan untuk memiliki tanah pertanian secara absentee ini bertujuan agar tanah pertanan yang berada disuatu tempat dapat dikelola sendiri oleh pemilik tanah yang bertempat tinggal di kecamatan letak tanah tersebut, sehingga hasil yang didapatkan dari tanah pertanian tersebut dapat maksimal. Penelitian ini bertujuan untuk mengkaji bentuk akibat hukum dari status tanah yang dalam sertipikatnya tidak dirubah sehingga dapat merugikan pembeli, yang mana seharusnya bisa disertipikatkan atas nama pembeli menjadi tidak bisa karena status tanah tersebut masih tanah sawah. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan yuridis empiris. Spesifikasi penelitian secara deskriptif analitis. Penelitian ini menggunakan data primer dan data sekunder yang diolah serta dianalisis menggunakan metode analisis kualitatif. Metode pengumpulan data dalam penelitian ini menggunakan metode observasi, wawancara, studi kepustakaan. Lokasi penelitian berada di Desa Sidorejo, Kecamatan Tirtomoyo, Kabupaten Wonogiri. Implikasi hukum dari pembelian tanah yang akta jual belinya dilakukan menggunakan nama orang lain dapat menimbulkan beberapa akibat hukum yang signifikan. Implikasi tersebut antara lain dalam jangka panjang akan menyulitkan pembeli ketika pembagian warisan.
STATUS HUKUM TANAH ADAT MASYARAKAT AKUR DI KEC. CIGUGUR KAB. KUNINGAN (STUDI PUTUSAN MAHKAMAH AGUNG NOMOR: 779K/Pdt/2017)
Authors: Hasibuan Fery , Silviana Ana , Triyono Triyono
Published: January 2025

Hukum adat yang berlaku pada masyarakat AKUR (Adat Karuhun Urang) Sunda Wiwitan di kec. Cigugur kab. Kuningan pemahaman tanah merupakan ikatan yang tidak dapat terputus dan tidak dapat dibagi wariskan. Penelitian ini bertujuan untuk mengetahui penguasaan, kedudukan atau status tanah masyarakat AKUR dengan meninjau putusan Mahkamah Agung Nomor: 779K/Pdt/2017 baik sebelum dan sesudah serta upaya yang dilakukan masyarakat adat untuk mempertahankan tanah adat. Metode yang digunakan dalam penelitian ini adalah penelitian normatif yang dimana menggunakan peraturan perundang-undangan, putusan pengadilan serta sejarah guna untuk memperoleh gambaran secara rinci dan menjawab isu hukum yang diteliti. Penelitian ini menggunakan pendekatan yuridis normatif  merupakan pendekatan kepustakaan yang berpedoman kepada peraturan-peraturan, dokumen putusan, buku-buku, literatur-literatur hukum dan bahan-bahan hukum lainnya yang memiliki hubungan permasalahan. Hasil penelitian ini bahwa penguasaan tanah adat AKUR sebelum putusan Mahkamah Agung Nomor : 779K/Pdt/2017 merupakan tanah adat masyarakat AKUR sementara dalam putusan tersebut memenangkan suatu pihak sebagai ahli waris. Pada saat ini, masyarakat AKUR dalam mempertahankan kepemilikan tanah melalui jalur non litigasi guna untuk menemukan titik terang. Kesimpulannya, status hukum tanah masyarakat AKUR sampai sekarang masih dikuasai oleh suatu pihak.
Pengaruh Kemampuan Mengakses dan Memahami Informasi Peserta KKN DR UIN Jakarta Terhadap Efikasi Diri Pencegahan Penyebaran Covid-19 di Masyarakat
Authors: Wisudani Salshabilla Ayu Fortuna , Azwar Muhammad
Published: January 2025

Background: One activity that students usually do before the end of the semester is to participate in KKN (Real Work Lecture). In 2020 and 2021 UIN Jakarta conducted a KKN-DR (Real Work Lecture from Home) activity, which was a from adoption of KKN during the Covid-19 pandemic. The pandemic situation has made almost all human activities take place online, which of course requires the ability to access and understand good information.Objective: The purpose of this research is to determine whether there is a significant influence of the ability to access and understand information on self-efficacy in preventing the spread of Covid-19.Methods: This research is associative quantitative research using multiple linear regression analysis.Results: The ability to access and understand information by UIN Jakarta KKN-DR participants did not have a significant effect on self-efficacy in preventing the spread of Covid-19. Simultaneously, the ability to access and understand information only contributed 0.9%, while 99.1% of self-efficacy was influenced by other factors, such as social support, motivation, availability of infrastructure, and economic conditions.Conclusion: Although the level of health information literacy of KKN-DR participants is relatively high, it is not enough to influence self-efficacy in preventing the spread of Covid-19. External factors, such as social support and public awareness are more dominant in the formation of self-efficacy. Implications, the importance of health socialization and education programs that involve various parties, including families and local communities, to increase community self-efficacy in preventing the spread of Covid-19. KKN-DR participants are expected to be able to play an active role in promoting health information literacy effectively to the community
Analisis Strategi Peningkatan Literasi Dasar pada Siswa Sekolah Dasar di Surabaya untuk Mendukung Peningkatan Nilai Pisa (Program for International Student Assessment): Systematic Literature Review
Authors: Hariyati Mutty , Arianto Fajar , Martadi Martadi , Agusti Fiqrie Restia
Published: January 2025

Background: The national level of basic literacy skills in Indonesia, as assessed by the Program for International Student Assessment (PISA), remains alarmingly low. This is an anomaly considering the implementation of the School Literacy Movement (Gerakan Literasi Sekolah/GLS) at the elementary school level, which has introduced various strategies for enhancing basic literacy skills.Objective: Therefore, this study aims to analyze strategies for improving basic literacy skills among elementary school students to support an increase in PISA scores.Methods: The research method employed in this study is the Systematic Literature Review (SLR), which involved analyzing journal articles published between 2019 and 2024 related to strategies for enhancing basic literacy skills in elementary school students in Surabaya. The researchers reviewed five journal articles obtained from Google Scholar.Results: The findings reveal several strategies that have been implemented to improve basic literacy skills among elementary school students, including literacy habituation through GLS and teaching methods such as the formation of literacy clubs, reading aloud, and the use of visual media. Necessary support includes the provision of facilities and infrastructure, awarding incentives, and collaborative support from all stakeholders. Meanwhile, obstacles include the absence of a dedicated literacy team, inadequate facilities and infrastructure, and changes in school leadership policies regarding literacy activities.Conclusion: The strategy to improve basic literacy involves holistic efforts through habitual literacy activities, student-centered teaching methods, and collaborative support from all stakeholders (schools, parents, communities, governments, and private sectors), aiming to enhance students' critical thinking, global mindset, and PISA performance while addressing challenges like inadequate resources and policy changes.
APPLICATION OF THE DYNAMIC FACTOR MODEL ON NOWCASTING SECTORAL ECONOMIC GROWTH WITH HIGH-FREQUENCY DATA
Authors: Supriyatna Putu Krishnanda , Prastyo Dedy Dwi , Akbar Muhammad Sjahid
Published: January 2025

Economic growth is crucial for planning, yet delayed data releases challenge timely decision-making. Nowcasting offers near-real-time insights using high-frequency indicators (released monthly, weekly, or even daily) to predict low-frequency variables (quarterly or yearly). This study uses high-frequency indicators (monthly), such as stock price changes, air quality, transportation data, financial conditions, and Google Trends, to nowcast quarterly GDP through the Dynamic Factor Model (DFM). The data used span from January 2010 until March 2023, which is split into two: January 2010 until March 2022 for training data and the rest as testing data. Compared to the benchmark Autoregressive Moving Average with Exogenous Variables (ARMAX) model, DFM demonstrates superior accuracy with lower symmetric Mean Absolute Percentage Error (sMAPE). In addition, to evaluate the model performance in nowcasting the GDP across the sector using DFM, the additional metrics, i.e., Root Mean Square Error (RMSE), Mean Absolute Deviation (MAD), and Adjusted R-squared, concluded that in the industrial and transportation sectors results in sufficient nowcasting of GDP, Meanwhile, In the financial sector, the results of the nowcasting GDP give poor estimation results that need improvement.
Václav II. a obecné učení v Praze
Authors: Šenk Martin
Published: January 2025

This contribution is dedicated to a report in the Chronicle of Zbraslav (Chronicon Aulae regiae) that informs about the intention of Wenceslaus II to establish a studium generale in Prague. It starts with a presentation of the sources and a detailed presentation of existing research regarding the king’s alleged intention. Then, some common misconceptions and errors are highlighted (such as the dating of Wenceslaus’s intention to 1294) and an alternative reading of the report in the chronicle presented and explained. Most notably, it is demonstrated that the report in the Chronicle of Zbraslav was just a fabulation, merely part of an effort to portray Wenceslaus II as the ideal ruler.
The clinical presentation and genetic diagnosis of Tangier disease in the pediatric age group
Authors: Öztürk Selcan , Doğan Muhammet Ensar , Kadıoğlu Yılmaz Banu , Güleç Ayten , Soylu Üstkoyuncu Pembe , Kardaş Fatih , Gümüş Hakan , Per Hüseyin
Published: January 2025

Objectives

Tangier disease (TD) is a rare autosomal recessive condition characterized by high-density lipoprotein (HDL) deficiency; involving symptoms of polyneuropathy, hyperplastic orange-yellow tonsils, vision disorder, and sudden cardiac death. The major clinical symptoms of TD may not all be co-present. This study evaluates patients diagnosed with TD in childhood to improve the possibility of early diagnosis of asymptomatic cases by reporting our patients’ clinical characteristics in order to minimize delayed diagnosis and emphasize the importance of TD, easily detected by HDL measurement.

Methods

This retrospective and cross-sectional study investigated seven patients from three different families diagnosed with TD.

Results

Four of seven patients were girls. Median age was 5.7 years at symptom onset and 6.5 years at diagnosis. The index case presented with neuropathy findings, and TD was diagnosed based on genetic analysis. Low lipid levels were determined in a sibling and cousins with cardiac death and gait disturbance in the family. TD was confirmed by genetic investigation. Our other patients were evaluated due to anemia, thrombocytopenia, yellow-orange hypertrophy in the tonsils, and organomegaly. Diagnosis was established with genetic analysis and low HDL. No coronary artery disease or ocular involvement was observed in any case.

Conclusions

All patients presenting with neuropathy and gait disorders should undergo detailed tonsil examinations and HDL tests. Genetic analysis should be carried out if necessary. Family screening should be recommended to patients with consanguineous marriages after diagnosis of TD.
On the generalized Snell–Descartes laws, shock waves, water wakes, and Cherenkov radiation
Authors: Genevet Patrice , Wright Nate , Johnson Jayden , Jana Aloke , Marinov Emil , Abou-Hamdan Loubnan
Published: January 2025

The modification of light’s trajectory after refracting through a boundary separating two media is a ubiquitous phenomenon in nature. The laws governing such refraction/reflection, known today as the Snell–Descartes laws of reflection and refraction, were established over four centuries ago and have since become foundational to the field of classical optics. Presently, with the advent of nano-photonic technology, a generalized version of these laws has been developed and implemented, vastly broadening the breadth of light manipulation methods. Despite their popularity, however, a simple and accessible derivation of the Snell–Descartes laws is still lacking, and their generalization is still largely missing from the physics curricula. Here, we use simple analogies between light’s refraction and reflection and other a priori unrelated radiating wave systems, namely, shock waves, water wakes, and Cherenkov radiation to derive both the classical and generalized Snell–Descartes laws, relying solely on simple and intuitive arguments. The basis of the derivation considers the excitation of a surface perturbation, induced by light incident at an angle on a boundary, that propagates at a velocity exceeding the phase velocity of light in the medium. The perturbation thereafter acts as a radiative source that reflects and refracts light away from the interface, at angles satisfying the classical Huygens interference condition. These derivations are meant to be accessible to a broad range of readers, including students of all levels, middle/high school teachers, and beyond.
ЭФФЕКТИВНОСТЬ СОЗДАНИЯ ЛЕСНЫХ КУЛЬТУР СОСНЫ ОБЫКНОВЕННОЙ НА ДРАЖНЫХ ОТВАЛАХ
Authors: ПЕТРОВ А.И. , ЗАЛЕСОВ С.В. , КОТОВА В.С.
Published: January 2025

Для добычи драгоценных металлов на Урале из лесного фонда изъяты значительные площади земель. После завершения разработки россыпных месторождений указанные земли требуют проведения рекультивационных работ. Низкое содержание в почвогрунтах, сформировавшихся в процессе добычи драгоценных металлов (золото, платина, серебро), элементов минерального питания и азота исключает сельскохозяйственное направление рекультивации без внесения значительных доз органических и минеральных удобрений. В то же время эффективно лесохозяйственное направление рекультивации созданием лесных культур сосны обыкновенной ( Pinus sylvestris L.). Установлено, что посев этих культур обусловливает их перевод в покрытые лесной растительностью земли при густоте подроста от 3.9 до 6.4 тыс. шт./га. Доля списанных (погибших) культур при этом составляет 10.9 % от созданных данным способом. При механизированной посадке 2-3-летних сеянцев сосны обыкновенной доля списанных культур составляет 4.3 %, а при ручной списания не зафиксировано. По причине мозаичности почвогрунтов перевод созданных лесных культур в покрытые лесной растительностью земли варьируется от 4 до 11 лет. Сохранность лесных культур можно увеличить использованием семян I класса качества местного происхождения, поскольку погибшие лесные культуры были созданы преимущественно семенами II класса качества.

Significant areas of land has been withdrawn from the forest fund for the extraction of precious metals in the Urals. After the completion of the development of alluvial deposits, these lands require reclamation work. Low content in soils formed during the extraction of precious metals (gold, platinum, silver) of mineral nutrition elements and nitrogen excluder the agricultural direction of reclamation without the introduction of significant dozes of organic and mineral fertilizers. At the same time, the forestry direction of reclamation is effective by creating Scots pine ( Pinus sylvestris L.) forest crops. It has been established that the creation of forest crops by sowing causes their transfer to lands covered with forest vegetation’s with a density of 3.9 to 6.4 thousand pieces per ha of pine undergrowth. The proportion of decommissioned dead forest crops is 10.9 % of those created by this method. When creating forest crops by mechanized planting of 2-3 year old seedlings of Scots pine, the share of decommissioned forest crops is 4.3 % and in manually planting of the same age seedlings decommission of forest crops was not recorded. Due to the mosaic nature of soils, the transfer of established forest crops covered with forest vegetation of the ground varies from 4 to 11 years. An increase in the preservation of forest crops can ensured by the use first class quality seeds of local origin, since the dead forest crops were created mainly by seeds of the second quality class.
Acute thoracic syndrome in children with sickle cell disease hospitalized in the paediatric department of the University Hospital Gabriel Touré (UH-GT)
Authors: Maiga B , Cissé ME , Dembélé A , K Traoré , I Traoré , K Sacko , F Traoré , B Traoré , A Touré , AA Diakité , H Diall , P Togo , A Doumbia , O Coulibaly , A Coulibaly , D Konaté , I Koné , F Dicko , B Togo
Published: January 2025

The aim of our work was to study the epidemiological and clinical aspects of acute thoracic syndrome in children with sickle cell disease hospitalized in the paediatric department of the Gabriel Touré University.

Materials and methods: We conducted a retrospective study over six (06) years, from January 1, 2017 to October 31, 2022, based on the records of children under 16 years of age with sickle cell disease confirmed by haemoglobin electrophoresis and hospitalized for acute thoracic syndrome in the paediatric department of the UH-GT.

Results: The frequency of hospitalization was 5.46%, the average age was 6.2 years, with a male predominance (sex ratio: 4.6). Nearly half of (studie subject?) (47.8%) had a history of vaso-occlusive crises. Chest pain was the main reason of consultation (61.5%). Hyperthermia, tachypnoea and hypoxia were present in 43.6%, 4.4% and 76.9% respectively. Pulmonary signs were dominated by respiratory distress (92.3%), with the homozygous form (SS) being the most common (92.3%). Bilateral basal opacities were found on frontal chest X-ray in 46.2% of patients. All patients were rehydrated. The mean duration of treatment was 9.1 days, with extremes of 2 and 31 days. Mortality rate was 2.6%, related to the degree of hypoxia (P= 0.001).

Conclusion: Acute thoracic syndrome is a frequent and serious acute complication of sickle cell disease. Any chest pain associated with respiratory signs and poor oxygen saturation should call for the diagnosis Acute thoracic syndrome.
Study of the “D” limestone bed for steelmaking use
Authors: Reyes Italo
Published: January 2025

The limestone deposits located in the Sogamoso region, Boyacá District, in the Eastern Cordillera of Colombia, provide the raw material for the steel industry and cement manufacturing. The main limestone deposits are developed along and adjacent to the great Soapaga Fault, which is the main geological structure in the region. Nowadays, the aim is to load the blast furnace with raw materials of the highest quality and, in the case of the calcination process, the need to produce highly competitive steels implies the use of limestone with optimal chemical characteristics. The Cretaceous rocks that outcrop in the region are of particular interest since they contain calcareous sequences that have been used for the steel and cement industries. Both the quality studies carried out in the different deposits in the region, as well as the analysis of the core samples obtained in the drilling programs, clearly indicated a great lateral continuity of the geochemical characteristics of some of the limestone layers. In the present study, the characterization of “D” limestone bed is carried out with special emphasis on the quality of the rock, and the results of the investigation clearly indicate that the material meets the specifications required for the steel manufacturing processes.
Sofiyivka Park. Travel notes
Authors: Mazurenko Snizhana
Published: January 2025

This popular science publication is dedicated to the historical part of the National Dendrological Park “Sofiyivka” of the NAS of Ukraine and the fantasy park “Nova Sofiyivka” located on the territory of this academic research institution (Uman).

The author describes their semantics, mythological and philosophical background, the main objects, and the most popular tourist routes. The illustrative material added to the book creates the effect of a virtual tour.

Aimed at non-specialist audience.
Effectiveness of an intervention on the family’s need for information in intensive care units
Authors: Guáqueta-Parada Sandra Rocio , Triana-Restrepo Martha Cecilia , Motta-Robayo Claudia Lorena , Henao-Castaño Ángela María , Ávila Myriam Lucía
Published: January 2025

Objective: To establish the effectiveness of a nursing intervention aimed at improving the satisfaction of the information needs of patients’ family in the Intensive Care Unit (ICU).
Materials and method: A prospective experimental study with a randomized intervention was conducted. The sample was recruited from an ICU in Bogotá, Colombia. The study population consisted of relatives of patients admitted to the ICU. The intervention’s outcomewas evaluated using the Critical Care Family Needs Inventory and the Critical Care Family Satisfaction Survey. The sample size was 66families. Randomization was performed using random numbers in permuted blocks, resulting in 33 families in the control group and 33 in the intervention group.
Results: A significant difference was found in communication and support. In the proximity dimension, there was statistical significance in talking to the same nurse daily (p = 0.009). In the dimensions of safety and comfort, there was no statistical significance. The overall satisfaction was favorable, with the intervention group showing amuch greater magnitude of change (p < 0.001***) compared to the control group (p < 0.01**).
Conclusion: Developing a structured intervention using information strategies such as face-to-face meetings, information leaflets, and a notebook to record concerns allows satisfying the need forinformation of patients’ families while  maintaining the quality of care, family well-being, and coping capacity.
(Re)construção do habitus do ser adolescente no uso do cigarro eletrônico
Authors: Da Silva Jaine Souto , Da Costa Lara Évilly Leandro , de Holanda David Adley Macêdo , Pereira Francisca Brigyda Alves , Soares Kaio César Barros , Fernandes Marcelo Costa , Temoteo Rayrla Cristina de Abreu
Published: January 2025

Objetivo: refletir sobre a utilização do cigarro eletrônico entre os adolescentes e sobre a naturalização do seu uso de acordo com o conceito nuclear de habitus de Pierre  Bourdieu.
Síntese de conteúdo: estudo teórico-reflexivo, estruturado a partir de artigos científicos que evidenciam a teoria bourdieusiana, a partir da qual é possível refletir sobre a incorporação de hábitos entre os adolescentes, sobretudo o tabagismo, e sobre a naturalização desses comportamentos em sociedade.
Conclusão: a análise do uso do cigarro eletrônico em adolescentes por meio da lente de Bourdieu revela, a partir do habitus, que as disposições internalizadas pelos indivíduos são moldadas por suas experiências sociais, influenciadas por interações e contextos, ao invés de mera escolha individual. Essa compreensão pode ser crucial para o desenvolvimento de intervenções que abordem o uso docigarro eletrônico em adolescentes, considerando a complexidade das relações sociais envolvidas.
Demystifying aggression in response to smoking bans in psychiatry
Authors: Oliveira Renata Marques de , Santos Jair Lício Ferreira , A Furegato Antonia Regina Ferreira
Published: January 2025

Objective: To investigate the aggressive behaviors of patients in a psychiatric hospital adhering to the anti-smoking law and to identify their associated factors. 
Materials and method: This cross-sectional epidemiological study analyzed the medical records of 573 discharged patients from a Brazilian psychiatric hospital. The response variables included verbal aggression, physical aggression, physical restraint, and mechanical restraint. Multiple Poisson regression models were applied for analysis.
Results: Approximately 48% of the patients were smokers. Aggression was found to be 121% higher among younger patients (aged 19-35), 73% higher among those with longer hospital stays, 55% higher among individuals hospitalized involuntarily, and 89% higher among those prescribed five or more psychotropic drugs, independent of other variables. Additionally, individuals hospitalized after the implementation of the smoking ban exhibited 55% fewer aggressive behaviors compared to those hospitalized prior to the ban.  
Conclusions: The study revealed that the associations between smoking and aggression, as well as the duration of hospitalization relative to the smoking ban, were influenced by personal and clinical variables. Cultural beliefs about the perceived benefits of smoking may be perpetuated among individuals with mental disorders, while older nursing professionals might influence younger colleagues’perspectives on permitting smoking in mental health settings as a means of mitigating aggression. Breaking this cycle of misinformation requires generating new knowledge and insights, which represents a significant contribution of this study.
Educación interprofesional en salud materno perinatal: percepción en medicina y enfermería
Authors: Parada Baños Arturo José , Galindo Huertas Mayra Solanye , Bejarano Beltrán Martha Patricia , González Vargas Angie Dayana , Pérez Cruz Karen Natalia , Prieto Nieto Angie Carolina , Rondón Barbosa Saray Valentina
Published: January 2025

Objetivo: comprender los discursos de estudiantes y docentes de medicina y enfermería frente a la educación interprofesional (EIP) en la salud materno perinatal.
Materiales y método: estudio cualitativo con análisis textual, contextual y sociológico del discurso desde la perspectiva sociohermenéutica, utilizando grupos focales de estudiantes y docentes de medicina y enfermería en el área de salud materno-perinatal. Se identificaron dos categorías emergentes: “lo institucional y el discurso académico” y “lo necesario para la EIP”.
Resultados: la institucionalidad tradicional, basada en un discurso académico uniprofesional, genera barreras y resistencias ante las demandas de un entorno de atención en salud cada vez más interdependiente. La EIP requiere habilidades como la empatía, la comunicación efectiva y el trabajo en equipo, así como el desarrollo de espacios de encuentro y diálogo, superando las jerarquías y las relaciones de poder y competencia para su adecuada implementación.
Conclusiones: el discurso de estudiantes y docentes de medicina y enfermería está permeado por la experiencia de barreras institucionales y dinámicas de poder arraigadas que se reproducen en los espacios de formación. Sin embargo, se percibe en los discursos el deseo de fomentar los diálogos interprofesionales para garantizar una colaboración efectiva entre los profesionales de la salud en la atención materno-perinatal.
Passive Strategies for thermal comfort in Amazonian Cities: The Case of Tena's Waterfront"
Authors: Simbaña Escobar Patricio , Rocchio Daniele , Alvarado Natalia , Cherrez Karina
Published: January 2025

This study explores the application of passive strategies focused on reducing urban heat islands, with special attention to improving pedestrian thermal comfort in Amazonian cities. Based on climatic data such as temperature, humidity, solar radiation, and wind speed, the impact of urban morphology on public space, particularly on the Tena River waterfront, is analyzed. Using the Grasshopper and Ladybug simulation tools, two scenarios were compared: one current, with 2-3 story buildings, and one proposed, which includes buildings up to 6 stories integrated with native vegetation. The results demonstrate that the proposed scenario not only increases shading but also significantly contributes to the reduction of temperatures, confirming the viability of these strategies to enhance sustainable urban design and improve the quality of life in Amazonian environments. The evaluation of the results highlights aspects to improve in urban development and emphasizes the importance of integrating simulation tools to design urban proposals and open spaces, guaranteeing a comfort zone for the user, encouraging pedestrian routes and therefore increasing social relations in nearby public spaces.
Development and Validation of an Affordable Calibration Method for Surface Plates
Authors: Garzón Daniela , Galvis Arroyave Jorge Luis , Plazas David , Gil Victor Hugo , Almanza Ovidio
Published: January 2025

The measurement and calibration of flat surfaces is highly relevant for precision engineering, length metrology, and optical systems. Hence, many National Metrology Institutes (NMIs) tend to offer calibration services in this regard. Typically, mechanical, electromechanical, and optical measuring techniques are applied, with uncertainties in the order of micrometers. However, these techniques necessitate expensive equipment that requires periodical calibration and maintenance, which not many laboratories can afford. This work presents the validation of an affordable and simple calibration technique for surface plates through the evaluation of metrological compatibility with a reference calibration method. A surface plate was calibrated with both methods under the same conditions to validate our proposal. The 2.9 µm uncertainty obtained with the new method demonstrates its reliability and usability for laboratories with surface plates up to 300 mm in length that have a grade AA to B flatness accuracy. Due to its low initial cost, reliability, and ease of implementation, the proposed calibration method can be recommended to all laboratories and industries that need to constantly verify their surface plates.
Desarrollo de la investigación para el fortalecimiento y transformación de la Gestión Escolar
Authors: Guevara Catty Orellana
Published: January 2025

Este ensayo pone de manifiesto la necesidad de búsqueda y gestión del conocimiento, a su vez, propone un modelo conceptual y metodológico de investigación dentro del ejercicio profesional con la participación de la comunidad educativa cuyo fin es la transformación del centro escolar. Se sustenta en el enfoque cualitativo y se centra en la reflexión que hacen las personas de su comportamiento en el accionar diario en relación con su entorno. Reflexiona en un modelo de cuatro fases: diagnóstica, estratégica, ejecución y evaluación. Presenta los aportes desde el planteamiento de un problema, el engranaje de una estrategia, la función iterativa del plan de acción y la importancia de la evaluación. Se concluye que los procesos de investigación son viables y, además, contribuyen con la gestión educativa para la mejora continua.