bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Investigation of TR-UHPC Composites and Flexural Behavior of TR-UHPC Composite Slab
Authors: Fu Jiuzhi , Zhang Yang , Qin Yanyue
Published: April 2024

In this investigation, the effects of different fabrics with 0.20% carbon fiber textile (CFT), 0.21% glass fiber textile (GFT), and 0.25% basalt fiber textile (BFT) on the properties of TR-UHPC were investigated by axial tensile tests. A bending test of the BFT-UHPC pavement slab was carried out. In terms of axial tensile performance, the fiber textiles ranked in the following sequence: CFT, BFT, and GFT. Additionally, the corresponding increases in the initial cracking strength and ultimate tensile strength were 18.0% and 21.9% for the CFT, 12.0% and 16.0% for the BFT, and only 9.1% and 8.0% for the GFT, respectively. Increasing the textile reinforcement ratio of the BFT from 0.25% to 0.50% improved the cracking stress and peak stress of the specimen by 12.0% and 15.9%, respectively. Moreover, the ultimate strain of the 0.50%-BFT reinforcing case was 1.4 times that of the 0.25%-BFT reinforcing case and 2.6 times that of the unreinforced specimen in terms of ductility. The results of the stacking test on the BFT reinforced UHPC pedestrian slab indicate that the mid-span deflection of the test slab under normal use load is 0.775 mm, which is only 19.8% of the deflection limit. Additionally, the test slab remained in the elastic stage without any cracking. The BFT effectively enhanced the toughness of the UHPC thin slab after cracking. It is expected to be applied as a novel structure to bridge pedestrian slabs, bridge decks, and other thin UHPC members, thereby improving the durability and mechanical properties of bridge structures.
Single-Cell Transcriptome Profiling of Scale Drop Disease Virus-Infected Asian Seabass (Lates calcarifer)
Authors: Loh Zhixuan , Lim Ting Wei , Howland Shanshan Wu , Awate Sunita , Renia Laurent , Chen Jinmiao , Ren Ee Chee
Published: April 2024

The study aims to characterize the immune cell landscape in convalescent Asian seabass (Lates calcarifer) blood samples after exposure to scale-drop disease virus (SDDV). Traditional immunophenotyping approaches used in human and mouse studies are impractical for non-model organisms like the Asian seabass due to the lack of specific antibody-based reagents. To overcome this challenge, 10x Genomics single-cell RNA sequencing was employed. The analysis of blood samples revealed 24 distinct leukocyte clusters, with elevated proportions of B cells, granulocytes, and T cells in the convalescent group compared to the uninfected group. While distinguishing granulocyte and macrophage subsets was challenging, the analysis of differential gene expression in the macrophage population indicated that the upregulated genes were linked to inflammatory processes. Specific T cell clusters showed notable expressions of cd4-1, cd8a, perforin-1 and il-2rβ, suggesting the presence of CD4+ T helper (Th), CD8+ cytotoxic T (Tc) cells, immature T cells, and naive T cells. Attempts to categorize CD4+ T cells into Th subtypes lacked clear distinctions, while CD8+ T cells exhibited three clusters, predominantly Tc1 cells. Furthermore, comparisons between convalescent and uninfected groups revealed increased percentages of activated and antibody-secreting B cells in the convalescent group. This single-cell analysis provides vital insights into the immune cell dynamics in convalescent and uninfected Asian seabass, providing valuable information on potential immune responses to SDDV infection.
Cosmography of the Minimally Extended Varying Speed-of-Light Model
Authors: Lee Seokcheon
Published: April 2024

Cosmography, as an integral branch of cosmology, strives to characterize the Universe without relying on pre-determined cosmological models. This model-independent approach utilizes Taylor series expansions around the current epoch, providing a direct correlation with cosmological observations and the potential to constrain theoretical models. Various observable quantities in cosmology can be described as different combinations of cosmographic parameters. Furthermore, one can apply cosmography to models with a varying speed of light. In this case, the Hubble parameter can be expressed by the same combination of cosmographic parameters for both the standard model and varying speed-of-light models. However, for the luminosity distance, the two models are represented by different combinations of cosmographic parameters. Hence, luminosity distance might provide a method to constrain the parameters in varying speed-of-light models.
Computational Approach to Third-Order Nonlinear Boundary Value Problems via Efficient Decomposition Shooting Method
Authors: Alzahrani K. A. , Alzaid N. A. , Bakodah H. O. , Almazmumy M. H.
Published: April 2024

The present manuscript proposes a computational approach to efficiently tackle a class of two-point boundary value problems that features third-order nonlinear ordinary differential equations. Specifically, this approach is based upon a combination of the shooting method with a modification of the renowned Adomian decomposition method. The approach starts by transforming the governing BVP into two appropriate initial-value problems, and thereafter, solves the resulting IVPs recurrently. In addition, the application of this method to varied test models remains feasible—of course, this is supported by the competing Runge–Kutta method, among others, and reported through comparison plots and tables.
Experimental and Model Analysis of the Thermal and Electrical Phenomenon of Arc Faults on the Electrode Pole of Lithium-Ion Batteries
Authors: Dong Chuanyou , Gao Bin , Li Yalun , Wu Xiaogang
Published: April 2024

Aiming at the electrical safety problem of a high-voltage lithium-ion battery system caused by an arc, and based on the establishment of a battery arc fault experimental platform, the evolution law of safety caused by an arc in the negative terminal of a battery system under different working conditions is discussed. On this basis, a battery arc evolution model based on magnetohydrodynamics is established to analyze the arc’s electro-thermal coupling characteristics to further obtain the distribution of the arc’s multi-physical field. The results show that the arc generated by the high-voltage grade battery pack will break down the cell’s shell and form a hole, resulting in electrolyte leakage. When the loop current is 10 A, the evolution law of arc voltage and current is basically the same under different supply voltages, charges, and discharges. The accuracy of the battery arc simulation model is verified by comparing the simulation with the experimental results. The research in this paper provides a theoretical basis for the electrical safety design of lithium-ion batteries caused by the arc, fills the gaps in the field of battery system arc simulation, and is of great significance for improving the safety performance of arc protection.
Leave the Milk for the Calf and Spread the Word: Exploring Factors Determining US Consumers’ Willingness to Try Plant-Based Milk Alternatives and Their Word-of-Mouth Sharing about Plant-Based Milk Alternatives
Authors: Rombach Meike , Cong Lei , Dean David L.
Published: April 2024

Plant-based milk alternatives are important beverages in US consumer markets. Sustainability, consumer awareness, lifestyle changes, and other value-based reasons are why these beverages are increasing in popularity. The present study is focused on plant-based milk alternatives. It builds on an online consumer survey that explores the factors explaining US consumers’ willingness to try plant-based milk alternatives and their word-of-mouth sharing about these beverages. Animal welfare concerns, environmental concerns, health consciousness, and dairy preferences are the factors under investigation. Results show that animal welfare, dairy preference, environmental concerns, and plant-based milk enthusiasm are significant predictors for willingness to try plant-based milk alternatives. Dairy preferences, environmental concerns, and plant-based milk enthusiasm predict the word-of-mouth factors. Overall, plant-based milk enthusiasm is the strongest driver for both consumer behaviours. Best practice recommendations address marketers in the US food and beverage industry and provide suggestions on how to target different consumer groups based on nutritional preferences and needs and on value-based product characteristics.
Applying Machine Learning for Enhanced MicroRNA Analysis: A Companion Risk Tool for Oral Squamous Cell Carcinoma in Standard Care Incisional Biopsy
Authors: Pruthi Neha , Yap Tami , Moore Caroline , Cirillo Nicola , McCullough Michael J.
Published: April 2024

Machine learning analyses within the realm of oral cancer outcomes are relatively underexplored compared to other cancer types. This study aimed to assess the performance of machine learning algorithms in identifying oral cancer patients, utilizing microRNA expression data. In this study, we implemented this approach using a panel of oral cancer-associated microRNAs sourced from standard incisional biopsy specimens to identify cases of oral squamous cell carcinomas (OSCC). For the model development process, we used a dataset comprising 30 OSCC and 30 histologically normal epithelium (HNE) cases. We initially trained a logistic regression prediction model using 70 percent of the dataset, while reserving the remaining 30 percent for testing. Subsequently, the model underwent hyperparameter tuning resulting in enhanced performance metrics. The hyperparameter-tuned model exhibited high accuracy (0.894) and ROC AUC (0.898) in predicting OSCC. Testing the model on cases of potentially malignant disorders (OPMDs) revealed that leukoplakia with mild dysplasia was predicted as having a high risk of progressing to OSCC, emphasizing machine learning’s advantage over histopathology in detecting early molecular changes. These findings underscore the necessity for further refinement, incorporating a broader set of variables to enhance the model’s predictive capabilities in assessing the risk of oral potentially malignant disorders.
Applications of Exosomal miRNAs from Mesenchymal Stem Cells as Skin Boosters
Authors: Zheng Jinmei , Yang Beibei , Liu Siqi , Xu Zhenfeng , Ding Zhimeng , Mo Miaohua
Published: April 2024

The skin is the outer layer of the human body, and it is crucial in defending against injuries and damage. The regenerative capacity of aging and damaged skin caused by exposure to external stimuli is significantly impaired. Currently, the rise in average life expectancy and the modern population’s aesthetic standards have sparked a desire for stem-cell-based therapies that can address skin health conditions. In recent years, mesenchymal stem cells (MSCs) as therapeutic agents have provided a promising and effective alternative for managing skin regeneration and rejuvenation, attributing to their healing capacities that can be applied to damaged and aged skin. However, it has been established that the therapeutic effects of MSC may be primarily mediated by paracrine mechanisms, particularly the release of exosomes (Exos). Exosomes are nanoscale extracellular vesicles (EVs) that have lipid bilayer and membrane structures and can be naturally released by different types of cells. They influence the physiological and pathological processes of recipient cells by transferring a variety of bioactive molecules, including lipids, proteins, and nucleic acids such as messenger RNAs (mRNAs) and microRNAs (miRNAs) between cells, thus playing an important role in intercellular communication and activating signaling pathways in target cells. Among them, miRNAs, a type of endogenous regulatory non-coding RNA, are often incorporated into exosomes as important signaling molecules regulating protein biosynthesis. Emerging evidence suggests that exosomal miRNAs from MSC play a key role in skin regeneration and rejuvenation by targeting multiple genes and regulating various biological processes, such as participating in inflammatory responses, cell migration, proliferation, and apoptosis. In this review, we summarize the recent studies and observations on how MSC-derived exosomal miRNAs contribute to the regeneration and rejuvenation of skin tissue, with particular attention to the applications of bioengineering methods for manipulating the miRNA content of exosome cargo to improve their therapeutic potential. This review can provide new clues for the diagnosis and treatment of skin damage and aging, as well as assist investigators in exploring innovative therapeutic strategies for treating a multitude of skin problems with the aim of delaying skin aging, promoting skin regeneration, and maintaining healthy skin.
NAFLD in the 21st Century: Current Knowledge Regarding Its Pathogenesis, Diagnosis and Therapeutics
Authors: Kounatidis Dimitris , Vallianou Natalia G. , Geladari Eleni , Panoilia Maria Paraskevi , Daskou Anna , Stratigou Theodora , Karampela Irene , Tsilingiris Dimitrios , Dalamaga Maria
Published: April 2024

Non-alcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. It is the most common liver disease in Western countries, andits global prevalence is estimated to be up to 35%. However, its diagnosis may be elusive, because liver biopsy is relatively rarely performed and usually only in advanced stages of the disease. Therefore, several non-invasive scores may be applied to more easily diagnose and monitor NAFLD. In this review, we discuss the various biomarkers and imaging scores that could be useful in diagnosing and managing NAFLD. Despite the fact that general measures, such as abstinence from alcohol and modulation of other cardiovascular disease risk factors, should be applied, the mainstay of prevention and management is weight loss. Bariatric surgery may be suggested as a means to confront NAFLD. In addition, pharmacological treatment with GLP-1 analogues or the GIP agonist tirzepatide may be advisable. In this review, we focus on the utility of GLP-1 analogues and GIP agonists in lowering body weight, their pharmaceutical potential, and their safety profile, as already evidenced inanimal and human studies. We also elaborate on other options, such as the use of vitamin E, probiotics, especially next-generation probiotics, and prebiotics in this context. Finally, we explore future perspectives regarding the administration of GLP-1 analogues, GIP agonists, and probiotics/prebiotics as a means to prevent and combat NAFLD. The newest drugs pegozafermin and resmetiron, which seem to be very promising, arealso discussed.
Decoding Tumor Angiogenesis for Therapeutic Advancements: Mechanistic Insights
Authors: Kaur Geetika , Roy Bipradas
Published: April 2024

Tumor angiogenesis, the formation of new blood vessels within the tumor microenvironment, is considered a hallmark of cancer progression and represents a crucial target for therapeutic intervention. The tumor microenvironment is characterized by a complex interplay between proangiogenic and antiangiogenic factors, regulating the vascularization necessary for tumor growth and metastasis. The study of angiogenesis involves a spectrum of techniques, spanning from biomarker assessment to advanced imaging modalities. This comprehensive review aims to provide insights into the molecular intricacies, regulatory dynamics, and clinical implications of tumor angiogenesis. By delving into these aspects, we gain a deeper understanding of the processes driving vascularization in tumors, paving the way for the development of novel and effective antiangiogenic therapies in the fight against cancer.
SARS-CoV-2-Related Olfactory Dysfunction: Autopsy Findings, Histopathology, and Evaluation of Viral RNA and ACE2 Expression in Olfactory Bulbs
Authors: Dell’Aquila Marco , Cafiero Concetta , Micera Alessandra , Stigliano Egidio , Ottaiano Maria Pia , Benincasa Giulio , Schiavone Beniamino , Guidobaldi Leo , Santacroce Luigi , Pisconti Salvatore , Arena Vincenzo , Palmirotta Raffaele
Published: April 2024

Background: The COVID-19 pandemic has been a health emergency with a significant impact on the world due to its high infectiousness. The disease, primarily identified in the lower respiratory tract, develops with numerous clinical symptoms affecting multiple organs and displays a clinical finding of anosmia. Several authors have investigated the pathogenetic mechanisms of the olfactory disturbances caused by SARS-CoV-2 infection, proposing different hypotheses and showing contradictory results. Since uncertainties remain about possible virus neurotropism and direct damage to the olfactory bulb, we investigated the expression of SARS-CoV-2 as well as ACE2 receptor transcripts in autoptic lung and olfactory bulb tissues, with respect to the histopathological features. Methods: Twenty-five COVID-19 olfactory bulbs and lung tissues were randomly collected from 200 initial autopsies performed during the COVID-19 pandemic. Routine diagnosis was based on clinical and radiological findings and were confirmed with post-mortem swabs. Real-time RT-PCR for SARS-CoV-2 and ACE2 receptor RNA was carried out on autoptic FFPE lung and olfactory bulb tissues. Histological staining was performed on tissue specimens and compared with the molecular data. Results: While real-time RT-PCR for SARS-CoV-2 was positive in 23 out of 25 lung samples, the viral RNA expression was absent in olfactory bulbs. ACE2-receptor RNA was present in all tissues examined, being highly expressed in lung samples than olfactory bulbs. Conclusions: Our finding suggests that COVID-19 anosmia is not only due to neurotropism and the direct action of SARS-CoV-2 entering the olfactory bulb. The mechanism of SARS-CoV-2 neuropathogenesis in the olfactory bulb requires a better elucidation and further research studies to mitigate the olfactory bulb damage associated with virus action.
Decision Model to Design Trust-Focused and Blockchain-Based Health Data Management Applications
Authors: Erler Christina , Bauer Ann-Marit , Gauger Friedrich , Stork Wilhelm
Published: April 2024

Many Blockchain-based approaches have been published in the field of health data management applications (HDMAs). However, no comprehensive guideline exists to guide the multiple and interdependent design decisions to develop such systems. This paper aims to support the HDMA system design processes by introducing a novel decision model. The model considers all relevant requirements, from regulatory context to user needs and trust considerations. To generate the decision model, we define a taxonomy that organizes previously published approaches by their technical design features and combines it with the trust assumptions of the participating actors according to the STRIDE method. The model aims to support a cohesive overall system design by addressing Blockchain type, off-chain storage, identity and access management, security decisions, and the specific use case of data donation. A group of experts evaluated the decision tree and its utility is demonstrated in three representative use cases. Special attention is paid to the use case of data donation via a data trustee, which is examined in detail.
Innovative Design Techniques for Sinusoidal-Web Beams: A Reliability-Based Optimization Approach
Authors: Cserpes Imre , Habashneh Muayad , Szép János , Movahedi Rad Majid
Published: April 2024

Existing studies often rely on deterministic numerical analyses for structural models. However, test results consistently highlight uncertainties, particularly in variables such as magnitude of the applied load, geometrical dimensions, material randomness, and limited experiential data. As a response, researchers have increasingly turned their attention to probabilistic design models, recognizing their crucial role in accurately predicting structural performance. This study aims to integrate reliability-based analysis into the numerical modeling of sinusoidal-web steel beams. Two sinusoidal-web beams are considered. The web and the flange thicknesses, in addition to the magnitude of the applied load, are treated as random variables with mean values and standard deviations. Notably, the study demonstrates the efficiency of the reliability index as a governing limit in the analysis process. A detailed comparison between deterministic and probabilistic designs of sinusoidal-web beams is conducted, focusing on the impact of introducing the nature of randomness. Therefore, this study’s results deepen our understanding of how uncertainties significantly influence deformations and stresses.
Revisiting Neuroblastoma: Nrf2, NF-κB and Phox2B as a Promising Network in Neuroblastoma
Authors: Peggion Sara , Najem Safiullah , Kolman Jan Philipp , Reinshagen Konrad , Pagerols Raluy Laia
Published: April 2024

Neuroblastoma is the most common solid extracranial tumor during childhood; it displays extraordinary heterogeneous clinical courses, from spontaneous regression to poor outcome in high-risk patients due to aggressive growth, metastasizing, and treatment resistance. Therefore, the identification and detailed analysis of promising tumorigenic molecular mechanisms are inevitable. This review highlights the abnormal regulation of NF-κB, Nrf2, and Phox2B as well as their interactions among each other in neuroblastoma. NF-κB and Nrf2 play a key role in antioxidant responses, anti-inflammatory regulation and tumor chemoresistance. Recent studies revealed a regulation of NF-κB by means of the Nrf2/antioxidant response element (ARE) system. On the other hand, Phox2B contributes to the differentiation of immature sympathetic nervous system stem cells: this transcription factor regulates the expression of RET, thereby facilitating cell survival and proliferation. As observed in other tumors, we presume striking interactions between NF-κB, Nrf2, and Phox2B, which might constitute an important crosstalk triangle, whose decompensation may trigger a more aggressive phenotype. Consequently, these transcription factors could be a promising target for novel therapeutic approaches and hence, further investigation on their regulation in neuroblastoma shall be reinforced.
Prenatal Diagnosis by Trio Clinical Exome Sequencing: Single Center Experience
Authors: Margiotti Katia , Fabiani Marco , Cima Antonella , Libotte Francesco , Mesoraca Alvaro , Giorlandino Claudio
Published: April 2024

Fetal anomalies, characterized by structural or functional abnormalities occurring during intrauterine life, pose a significant medical challenge, with a notable prevalence, affecting approximately 2–3% of live births and 20% of spontaneous miscarriages. This study aims to identify the genetic cause of ultrasound anomalies through clinical exome sequencing (CES) analysis. The focus is on utilizing CES analysis in a trio setting, involving the fetuses and both parents. To achieve this objective, prenatal trio clinical exome sequencing was conducted in 51 fetuseses exhibiting ultrasound anomalies with previously negative results from chromosomal microarray (CMA) analysis. The study revealed pathogenic variants in 24% of the analyzed cases (12 out of 51). It is worth noting that the findings include de novo variants in 50% of cases and the transmission of causative variants from asymptomatic parents in 50% of cases. Trio clinical exome sequencing stands out as a crucial tool in advancing prenatal diagnostics, surpassing the effectiveness of relying solely on chromosomal microarray analysis. This underscores its potential to become a routine diagnostic standard in prenatal care, particularly for cases involving ultrasound anomalies.
The Dynamics of Commodity Research: A Multi-Dimensional Bibliometric Analysis
Authors: Nica Ionuț , Chiriță Nora
Published: April 2024

This study presents a comprehensive bibliometric analysis conducted in R Studio of the scientific landscape regarding commodity markets, trading strategies, sustainable production, integration of technologies such as machine learning, and their economic impacts, covering publications from 1974 to 2023. Employing a sophisticated query in Scopus, we meticulously compiled and analyzed data, revealing an annual growth rate of 10.46% in related scientific publications, with an average citation rate of 6.60 per document. The results indicate sustained interest in commodity research over time, with a significant increase observed in scientific production, particularly since the early 2008s. International collaboration is prominent, reflecting the global nature of research in commodity markets. Key themes such as “futures markets”, “commodity prices”, and “energy commodities” emerge from the analysis of keywords and bigrams, highlighting areas of interest within the field. Additionally, thematic mapping highlights emerging and niche themes in commodity research, providing insight into evolving trends and areas of specialization. Factorial analysis of keywords reveals the underlying structures of association between key concepts, shedding light on the intricate dynamics of research in the field of commodities. This research delineates the complex interplay between commodity markets and global economic dynamics, offering invaluable insights for academics, policymakers, and market participants aiming to navigate the intricate world of commodities in the digital age.
The Study of Molecules and Processes in Solution: An Overview of Questions, Approaches and Applications
Authors: Tshilande Neani , Mammino Liliana , Bilonda Mireille K.
Published: April 2024

Many industrial processes, several natural processes involving non-living matter, and all the processes occurring within living organisms take place in solution. This means that the molecules playing active roles in the processes are present within another medium, called solvent. The solute molecules are surrounded by solvent molecules and interact with them. Understanding the nature and strength of these interactions, and the way in which they modify the properties of the solute molecules, is important for a better understanding of the chemical processes occurring in solution, including possible roles of the solvent in those processes. Computational studies can provide a wealth of information on solute–solvent interactions and their effects. Two major models have been developed to this purpose: a model viewing the solvent as a polarisable continuum surrounding the solute molecule, and a model considering a certain number of explicit solvent molecules around a solute molecule. Each of them has its advantages and challenges, and one selects the model that is more suitable for the type of information desired for the specific system under consideration. These studies are important in many areas of chemistry research, from the investigation of the processes occurring within a living organism to drug design and to the design of environmentally benign solvents meant to replace less benign ones in the chemical industry, as envisaged by the green chemistry principles. The paper presents a quick overview of the modelling approaches and an overview of concrete studies, with reference to selected crucial investigation themes.
Irrigation and Débridement of the Thumb Flexor Sheath for Tenosynovitis—An Anatomic Study for the Optimisation of Surgical Techniques in Cadaveric Specimens
Authors: Grant James W. , LeBlond Louis , Woodley Stephanie J.
Published: April 2024

Background: Treatment of a flexor tendon sheath infection of the thumb usually involves prompt surgical irrigation and debridement (ID). There are few descriptions of this procedure despite the unique anatomy of the thumb flexor sheath. The aim of this study was to investigate thumb flexor sheath ID and explore the relevant anatomy. Methods: The current ID technique was performed on eight embalmed cadaveric hands. Coloured latex was injected into the sheath, and the surrounding region was dissected. Outcomes of interest were the distribution of latex, the success of the procedure, and the anatomy of the radial bursa. Results: Latex was successfully injected into all specimens, although A1 pulley stenosis caused significant resistance to flow. Latex filled the radial bursa (four specimens), reached the distal boundary of the transverse carpal ligament (three), or did not pass the A1 pulley (one); in addition, latex was found in the deep spaces of the hand and wrist (five specimens). The radial bursa was located at a median (range) of 33.2 (23.9–34.5) mm proximal to the carpometacarpal joint and at 7.8 (0–14.0) mm distal to the distal border of the pronator quadratus. Conclusion: These findings contribute to the existing body of knowledge on the anatomy of the thumb flexor sheath and radial bursa, and will help guide hand surgeons to perform thorough ID for infection. A modified surgical technique is presented, which may help further inform the treatment of pyogenic flexor tenosynovitis and other serious hand conditions.
Differences in Total Factor Productivity and the Pattern of International Trade
Authors: Bertsatos Gerassimos , Tsounis Nicholas
Published: April 2024

In this work, we develop a trade model that explains the pattern of trade between countries based on differences in total factor productivity (TFP) while also accounting for differences in relative factor endowments. The novelty stems from the introduction of production functions derived by combining the Ricardian and Heckscher–Ohlin–Samuelson (H-O-S) theories, with TFP differences serving as the basis of comparative advantage. To this end, a testable hypothesis is derived. For the empirical measurement of the TFP in each industry and country, a constant elasticity of substitution (CES)-type production function was employed, and the TFP was calculated as the Solow residual from the production function’s fixed term. To offer a better understanding, the model was tested for the bilateral trade between Germany and Russia, and Germany and the Czech Republic. It was found that TFP differences can be used as a basis for explaining comparative advantages and, consequently, the bilateral pattern of trade between two countries.
Reluctance to Authenticity-Imbued Social Robots as Child-Interaction Partners
Authors: Istenič Andreja , Latypova Liliya , Rosanda Violeta , Turk Žiga , Valeeva Roza , Zhai Xuesong
Published: April 2024

We are facing the rapid development of educational technology and social robots tested in classrooms. Research has identified teachers’ caution and concerns about these robots’ social skills. Pre-service education is critical for forming beliefs and preparing teachers for the future classroom and innovations in educational technology. In the present study, exploratory factor analysis is applied to examine pre-service teachers’ concerns about social robots’ instructional integration in the role of social agents interacting with children. We apply a concerns scale encompassing the instructional and socio-emotional concerns regarding robots’ instructional integration in the classroom environment. In this study, the scale, which was developed in Slovenia, is examined in the Russian cultural context. Based on the concerns scale, exploratory factor analysis identifies a one-factor solution with five statements (of a six-item factor) shared with the Slovene sample, adding three statements focusing on the importance of the teacher’s role. Russian pre-service teachers share concerns with Slovene pre-service teachers and further highlight the authenticity of unique human relationships and interactions. Slovenian pre-service teachers are more focused on children’s social skills and well-being, while Russian participants give special attention to the teacher’s role and value and believe that it would be wrong to place the robot in a classroom for such a purpose. They do not consider the robot’s human-like interaction skills sufficient for it to be assigned the role of a social agent and interaction partner in the classroom. The inappropriateness of the robot for pedagogical interactions and relationships is the basis of all their concerns. The Kruskal–Wallis test identified the moderate magnitude of the difference between the groups (ε2 = 0.07–0.12), with Russian pre-service teachers presenting the strongest reluctance towards authenticity-imbued social robots in pedagogical roles. The authors emphasize the need to clearly state stakeholders (roboticists, teachers, children, parents) in the research design and their roles in the evaluation of robot implementation.
Analyzing the Associations between Facets of Physical Literacy, Physical Fitness, and Physical Activity Levels: Gender- and Age-Specific Cross-Sectional Study in Preadolescent Children
Authors: Rajkovic Vuletic Petra , Gilic Barbara , Zenic Natasa , Pavlinovic Vladimir , Kesic Marijana Geets , Idrizovic Kemal , Sunda Mirela , Manojlovic Marko , Sekulic Damir
Published: April 2024

Physical literacy (PL) is theorized to be an important determinant of physical fitness (PF) and physical activity levels (PALs), but studies have rarely examined possible correlations between PL, PF, and PAL in preadolescent children. This study aimed to evaluate age-specific and gender-specific correlations between the affective and cognitive domains of PL (PLAC), PF, and PAL in preadolescents. Additionally, the test–retest reliability of the applied PF tests was examined. The participants were 107 children (9 to 11 years of age; 53 girls). Apart from gender and school age (third graders, fourth graders), the variables included PLAC, PAL, and PF. PF was evaluated by anthropometrics and body composition indices, sit-ups, push-ups, PACER tests, torso lifts, and broad jump. PLAC was evaluated using the PLAYself questionnaire, and the PAQ-C was used to evaluate PAL. The test–retest reliability of the PF tests was appropriate to high (ICC: 0.65–0.91). Analyses showed nonsignificant associations between PLAC and PAL in both genders and age groups. PAL was significantly correlated with PL in girls (low correlation) and fourth graders (moderate correlation). The nonsignificant associations between PLAC and PF could be a consequence of the influence of biological maturity on PF in this age group. The correlation between PAL and PLAC can be explained by the differences in physical activity habits between genders and age groups, with participation in structured physical activities (organized sports and physical education) being the most important source of PAL in girls and older children.
A Systematic Review with a Meta-Analysis of the Motivational Climate and Hedonic Well-Being Constructs: The Importance of the Athlete Level
Authors: Lochbaum Marc , Sisneros Cassandra
Published: April 2024

Motivational climate is known to relate to individual behaviors, emotions, and thoughts. Hedonic or subjective well-being includes self-assessed positive affect (i.e., pleasant affect, moods, and emotions), negative affect (i.e., unpleasant affect, moods, and emotions), and life or domain-specific satisfaction. The aim of this review was to quantify the relationships between task and ego motivational climate scales and measures representing hedonic well-being with sports participants. Potential moderators of the motivational climate and hedonic well-being were examined. This review followed the PRISMA guidelines (PROSPERO ID CRD42023470462, registered 28 October 2023). From five relevant databases, one relevant review, and hand searching, 82 articles totaling 26,378 participants (46.3% female) met the inclusion criteria. The articles spanned publication dates from 1993 to 2023, representing 18 countries, various team and individual sports, and athletes competing in elite (e.g., Olympic) to grassroot (e.g., club sport) competitions. To meta-analyze the motivational climate and hedonic well-being relationships, the random-effects model was used. For the moderation analyses, the mixed-effects model was used. The task or mastery climate relationships were medium in magnitude with positive affect and satisfaction and small with negative affect. The ego or performance climate relationships were small in magnitude for positive affect, negative affect, and satisfaction. Evidence of bias existed in the motivational climate and hedonic well-being relationships. For moderation analyses, athlete level (i.e., elite vs. non-elite) moderated (p < 0.05) the task (elite, r = 0.23; non-elite, r = 0.34) and ego motivational climate (elite, r = −0.02; non-elite, r = −0.13) and positive affect and satisfaction combined relationships. In conclusion, the motivational climate and hedonic well-being relationships were stronger for the task climate than for the ego climate. The finding that elite athlete correlations appeared dampened is important for future research. Even with the damped relationships, practitioners, from the Olympics to local clubs, should ensure the promotion of the task climate to maximize positive affect and satisfactions in and around the sport experience.
Persona-Identified Chatbot through Small-Scale Modeling and Data Transformation
Authors: Keum Bitna , Sun Juoh , Lee Woojin , Park Seongheum , Kim Harksoo
Published: April 2024

Research on chatbots aimed at facilitating more natural and engaging conversations is actively underway. With the growing recognition of the significance of personas in this context, persona-based conversational research is gaining prominence. Despite the abundance of publicly available chit-chat datasets, persona-based chat datasets remain scarce, primarily due to the higher associated costs. Consequently, we propose a methodology for transforming extensive chit-chat datasets into persona-based chat datasets. Simultaneously, we propose a model adept at effectively incorporating personas into responses, even with a constrained number of parameters. This model can discern the most relevant information from persona memory without resorting to a retrieval model. Furthermore, it makes decisions regarding whether to reference the memory, thereby enhancing the interpretability of the model’s judgments. Our CC2PC framework demonstrates superior performance in both automatic and LLM evaluations when compared to high-cost persona-based chat dataset. Additionally, experimental results on the proposed model indicate the improved persona-based response capabilities.
A Brief Review of Single-Event Burnout Failure Mechanisms and Design Tolerances of Silicon Carbide Power MOSFETs
Authors: Grome Christopher A. , Ji Wei
Published: April 2024

Radiation hardening of power MOSFETs (metal oxide semiconductor field effect transistors) is of the highest priority for sustaining high-power systems in the space radiation environment. Silicon carbide (SiC)-based power electronics are being investigated as a strong alternative for high power spaceborne power electronic systems. SiC MOSFETs have been shown to be most prone to single-event burnout (SEB) from space radiation. The current knowledge of SiC MOSFET device degradation and failure mechanisms are reviewed in this paper. Additionally, the viability of radiation tolerant SiC MOSFET designs and the modeling methods of SEB phenomena are evaluated. A merit system is proposed to consider the performance of radiation tolerance and nominal electrical performance. Criteria needed for high-fidelity SEB simulations are also reviewed. This paper stands as a necessary analytical review to intercede the development of radiation-hardened power devices for space and extreme environment applications.
A Lightweight, Efficient, and Physically Secure Key Agreement Authentication Protocol for Vehicular Networks
Authors: Wang Shaoqiang , Fan Ziyao , Su Yu , Zheng Baosen , Liu Zhaoyuan , Dai Yinfei
Published: April 2024

In the contemporary era, Vehicular Ad Hoc Networks (VANETs) have emerged as a vital technology in intelligent transportation systems, substantially enhancing the overall travel experience by providing advanced services to vehicles while ensuring driver safety. Despite the notable improvements, the inherent complexity of VANETs presents persistent security challenges, encompassing issues such as privacy preservation for vehicles, message authentication, and constraints in computational power and network bandwidth. Various authentication protocols have been designed for VANETs. However, many of these protocols exhibit significant vulnerabilities, rendering them insecure and unreliable in the face of diverse security threats, such as denial of service, replay, forgery, and impersonation attacks. Moreover, some existing schemes encounter limitations, including high computational complexity and the introduction of additional communication overhead and computational costs. To tackle these concerns, we designed a lightweight and secure identity authentication protocol based on elliptic curve cryptography with the objective of furnishing an effective and secure data transmission mechanism across a public communication channel for the Internet of Vehicles. In addition, we introduce Physically Unclonable Functions (PUFs) to ensure physical layer security during the communication process. A detailed security analysis demonstrates that the proposed protocol is resilient against various attacks. Through a comparative analysis with existing relevant protocols, in scenarios with a high density of vehicles, the algorithm demonstrates significantly lower computational costs and communication overhead than the related protocols, indicating that the proposed protocol is lightweight and efficient. Consequently, the empirical findings indicate that our protocol surpasses others in terms of reliability, user convenience, and practicality for ensuring secure data transmission within VANETs.
Evaluation of Immune Protection of a Bivalent Inactivated Vaccine against Aeromonas salmonicida and Vibrio vulnificus in Turbot
Authors: Xiu Yunji , Yi Jingyuan , Feng Ruixin , Song Jiaxue , Pang Yunfei , Liu Peng , Zhou Shun
Published: April 2024

The Aeromonas salmonicida is responsible for causing furunculosis in various fish species. Furunculosis is a ubiquitous disease that affects the aquaculture industry and causes the mass mortality of turbot. Vibrio vulnificus is a pathogen that causes skin ulcers and hemorrhagic septicemia in fish, resulting in significant mortality in aquaculture. In this study, we have established a bivalent inactivated vaccine against A. salmonicida and V. vulnificus with Montanide™ ISA 763 AVG as an adjuvant. This bivalent inactivated vaccine was used to immunize turbot by intraperitoneal injection, and the relevant immune indexes were detected. The results demonstrate that the bivalent inactivated vaccine exhibited a relative percent survival (RPS) of 77% following A. salmonicida and V. vulnificus intraperitoneal challenge. The vaccinated group exhibited higher levels of acid phosphatase activity and lysozyme activity compared to the control group. ELISA results showed a significant increase in serum antibody levels in immunized turbot, which was positively correlated with immunity. In the kidney tissue, related immune genes (TLR5, CD4, MHCI and MHCII) were up-regulated significantly, showing that the vaccine can induce cellular and humoral immune responses in turbot. In conclusion, the bivalent inactivated vaccine against A. salmonicida and V. vulnificus was immunogenic, efficiently preventing turbot from infection, which has the potential to be applied in aquaculture.
Golden Barrel Cactus: Unveiling Its Potential as a Functional Food and Nutraceutical Source
Authors: Chaicharoenaudomrung Nipha , Posridee Kakanang , Oonsivilai Anant , Oonsivilai Ratchadaporn
Published: April 2024

A comprehensive analysis of phytochemicals, digestive stability, and bioaccessibility was conducted on a golden barrel cactus extract from 3- and 6-year-old plants. Both ages contained lutein and four chlorophyll derivatives (chlorophyll a, b, pheophytin a, and b), but younger cacti revealed a significantly higher abundance. Total phenolics reached 3545.35 mg gallic acid equivalent/100 g dry weight in the 3-year-old extracts compared to 2557.96 mg/100 g in the older ones. Antioxidant activity, assessed by DPPH, ABTS, and FRAP assays, was consistently higher in the younger group. While digestion impacted all compounds, lutein exhibited relative stability at 69.03% and 58.33% retention for 3- and 6-year-old extracts, respectively. Chlorophylls displayed lower stability (37.64% and 33.34% remaining for younger and older cacti) despite showing higher bioaccessibility (73.385% and 64.65%). Phenolics also demonstrated promising bioaccessibility (76.39% and 69.88%) despite moderate digestive degradation (60.52% and 56.89% retained). Conclusively, all investigated attributes—phytochemical content, digestive stability, and bioaccessibility—favored the younger golden barrel cactus extracts. This highlights the crucial role of plant age in maximizing the potential health benefits of these extracts.
New Approach Methods to Assess the Enteropathogenic Potential of Strains of the Bacillus cereus Group, including Bacillus thuringiensis
Authors: Fichant Arnaud , Lanceleur Rachelle , Hachfi Salma , Brun-Barale Alexandra , Blier Anne-Louise , Firmesse Olivier , Gallet Armel , Fessard Valérie , Bonis Mathilde
Published: April 2024

Bacillus cereus (Bc) is a wide group of Gram-positive and spore-forming bacteria, known to be the etiological agents of various human infections, primarily food poisoning. The Bc group includes enteropathogenic strains able to germinate in the digestive tract and to produce enterotoxins such as Nhe, Hbl, and CytK. One species of the group, Bacillus thuringiensis (Bt), has the unique feature of producing insecticidal crystals during sporulation, making it an important alternative to chemical pesticides to protect crops from insect pest larvae. Nevertheless, several studies have suggested a link between the ingestion of pesticide strains and human cases of food poisoning, calling their safety into question. Consequently, reliable tools for virulence assessment are worth developing to aid decision making in pesticide regulation. Here, we propose complementary approaches based on two biological models, the human intestinal Caco-2 cell line and the insect Drosophila melanogaster, to assess and rank the enteric virulence potency of Bt strains in comparison with other Bc group members. Using a dataset of 48 Bacillus spp. strains, we showed that some Bc group strains, including Bt, were able to induce cytotoxicity in Caco-2 cells with concomitant release of IL-8 cytokine, a landmark of pro-inflammatory response. In the D. melanogaster model, we were able to sort a panel of 39 strains into four different classes of virulence, ranging from no virulence to strong virulence. Importantly, for the most virulent strains, mortality was associated with a loss of intestinal barrier integrity. Interestingly, although strains can share a common toxinotype, they display different degrees of virulence, suggesting the existence of specific mechanisms of virulence expression in vivo in the intestine.
Active Films of Cassava Starch Incorporated with Carvacrol Nanocapsules
Authors: Krümmel Aline , Pagno Carlos Henrique , Malheiros Patrícia da Silva
Published: April 2024

The synthesis of active films with natural antimicrobials from renewable sources offers an alternative to conventional non-biodegradable packaging and synthetic additives. This study aimed to develop cassava starch films with antimicrobial activity by incorporating either free carvacrol or chia mucilage nanocapsules loaded with carvacrol (CMNC) and assess their impact on the physical, mechanical, and barrier properties of the films, as well as their efficacy against foodborne pathogens. The addition of free carvacrol led to a reduction in mechanical properties due to its hydrophobic nature and limited interaction with the polymeric matrix. Conversely, CMNC enhanced elongation at break and reduced light transmission, with a more uniform distribution in the polymeric matrix. Films containing 8% carvacrol exhibited inhibitory effects against Salmonella and Listeria monocytogenes, further potentiated when encapsulated in chia mucilage nanocapsules. These findings suggest that such films hold promise as active packaging materials to inhibit bacterial growth, ensuring food safety and extending shelf life.