bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMILIHAN FITUR DENGAN FORWARD SELECTION PADA METODE K-NEAREST NEIGHBOR UNTUK PREDIKSI BIMBINGAN KONSELING SISWA
Authors: Nugroho Wildani Eko
Published: August 2023

Salah satu masalah yang sulit untuk diramalkan yang ada disekolah adalah masalah bimbingan dan koseling. Bagi individu yang memiliki wewenang untuk mengambil keputusan, prediksi yang akurat diperlukan untuk mendukung pengambilan keputusan. KNN merupakan salah satu metode yang dapat melakukan prediksi terutama untuk prediksi bimbingan konseling. Pendekatan algoritma KNN yang digunakan untuk melakukan pengujian dan eksperimen terhadap 388 data siswa, memperoleh hasil akurasi sebanyak 96.40%. Setelah dilakukan optimasi menggunakan pemilihan fitur dengan forward selection mengalami kenaikan akurasi sebesar 0.51%. Hasil akhir dari akurasi yang diperoleh setelah mengalami kenaikan tingkat nilai akurasi sebesar 96.91% dengan jumlah siswa yang tidak harus melakukan bimbingan konseling sebanyak 362 siswa dan 62 siswa harus melakukan bimbingan konseling.
Ahmed Vâlâ Nureddin'in Popüler Aşk Romanları Üzerine
Authors: GÜLTEKİN Mustafa
Published: August 2023

Ahmed Vâlâ Nureddin, Türk edebiyatında popüler romancılığın revaçta olduğu bir dönemde tefrika dâhil birçok romana imza atmış bir isimdir. Yazarın romanları; estetik kaygılardan uzak, popüler ve kitle kültürünü beslemeye yönelik kaygılarla yazılmış popüler roman sınıfına girmektedir. Popüler romancılığın tüm yönlerini kullanarak yazdığı birçok romanı bulunan Ahmed Vâlâ Nureddin, ağırlıklı olarak popüler âşk romanları kaleme almıştır. Literatürde, Ahmed Vâlâ Nureddin’e ait birçok popüler roman yer almış olsa da, bu çalışma, yazarın sadece kitaplaşan popüler âşk romanlarını incelemektedir. Yazarın, 1933-1962 yılları arasında kitap halinde basılan on adet popüler âşk romanı bu çalışmanın esasını oluşturmaktadır. Bu romanlar, popüler romancılığın genel özelliklerinin hemen hemen tümünü barındıran özellikteki yapılarıyla dikkati çeken eserlerdir. Popüler romancılığın olay örgüsü, kişi kadrosu, anlatım tekniği, anlatıcı, zaman, mekân alanlarındaki formülasyonlu yapısının Ahmed Vâlâ Nureddin’in romancılığına yansıyan yönleri bu makalede ortaya konmuştur. Bu makale, özelde Ahmed Vâlâ Nureddin’in popüler romancılığını ortaya koyduğu gibi teorik olarak popüler âşk romanlarının yapısını da göstermektedir.
Використання евристичних методів у виконанні практичних завдань з дизайнерських дисциплін
Authors: Омельченко Ольга
Published: August 2023

У статті висвітлено практичне значення використання евристичних методів у виконанні контрольних практичних завдань з дизайнерських дисциплін. На основі принципу послідовності консистентної інформації, методів евристичного аналізу, інтерпретації та стилізації, методу асоціацій визначається ефективність підготовки дизайнерів у вищих навчальних закладах, активізується творчий пошук, розвиваються навички графічного, пластичного, образного, цілісного формоутворення. у статті визначено та конкретизовано комплекс евристичних методів, здатних ефективніше вплинути на процес підготовки майбутніх дизайнерів, які допомагають розкрити індивідуальні здібності студентів, розвинути художнє мислення, смак, фантазію, сміливість до експерименту. Розкрито сутність евристичних методів навчання у виконанні практичних завдань з дизайнерських дисциплін. Висвітлено комплекс завдань з курсу «Основи композиції» (кольорознавство, формоутворення) з використанням евристичних методів (евристичного аналізу, інтерпретації та стилізації, методу асоціацій тощо). Надано приклади створення об’ємних композицій через ідеї розвитку та варіанти перетворення крапки в лінії, лінії в плями, плями в об’єм з використанням метру і ритму. Доведено ефективність представлених завдань у створенні декоративних композицій з будь яких матеріалів і технік: вітражу, гобелену, аплікації, інтарсії, розпису, ескізів абстрактної міні колекції одягу тощо.
Artesunate reduces sepsis-mediated acute lung injury in a SIRT1-dependent manner
Authors: Liu Zhaohui , Meng Yanli , Miao Yu , Yu Lili , Yu Qiannan
Published: August 2023

Introduction: Sepsis-mediated acute lung injury (ALI) is a critical clinical condition. Artesunate (AS) is a sesquiterpene lactone endoperoxide that was discovered in Artemisia annua, which is a traditional Chinese herb. AS has a broad set of biological and pharmacological actions; however, its protective effect on lipopolysaccharide (LPS)-induced ALI remains unclear. Methods: LPS-mediated ALI was induced in rats through bronchial LPS inhalation. Then NR8383 cells were treated with LPS to establish an in vitro model. Further, we administered different AS doses in vivo and in vitro. Results: AS administration significantly decreased LPS-mediated pulmonary cell death and inhibited pulmonary neutrophil infiltration. Additionally, AS administration increased SIRT1 expression in pulmonary sections. Administration of a biological antagonist or shRNA-induced reduction of SIRT1 expression significantly inhibited the protective effect of AS against LPS-induced cellular injury, pulmonary dysfunction, neutrophil infiltration, and apoptosis. This demonstrates that enhanced SIRT1 expression is crucially involved in the observed protective effects. Conclusion: Our findings could suggest the use of AS for treating lung disorders through a mechanism involving SIRT1 expression.
Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats
Authors: Gohari Mahmoudabad Arezoo , Gheybi Fatemeh , Mehrabi Mohsen , Masoudi Alireza , Mobasher Zeinab , Vahedi Hamid , Gharravi Anneh Mohammad , Bitaraf Fatemeh Sadat , Rezayat Sorkhabadi Seyed Mahdi
Published: August 2023

Introduction: Silymarin proved to be a beneficial herbal medicine against many hepatic disorders such as alcoholic liver disease (ALD). However, its application is restricted due to its low bioavailability and consequently decreased efficacy. We herein used a nano-based approach known as "phytosome", to improve silymarin bioavailability and increase its efficacy. Methods: Phytosome nanoparticles (NPs) were synthesized using thin film hydration method. NPs size, electrical charge, morphology, stability, molecular interaction, entrapment efficiency (EE %) and loading capacity (LC %) were determined. Moreover, in vitro toxicity of NPs was investigated on mesenchymal stem cells (MSCs) viability using MTT assay. In vivo experiments were performed using 24 adult rats that were divided into four groups including control, ethanol (EtOH) treatment, silymarin/EtOH treatment and silymarin phytosome/EtOH, with 6 mice in each group. Experimental groups were given 40% EtOH, silymarin (50 mg/kg) and silymarin phytosome (200 mg/kg) through the gastric gavage once a day for 3 weeks. Biochemical parameters, containing ALP, ALT, AST, GGT, GPx and MDA were measured before and after experiment to investigate the protective effect of silymarin and its phytosomal form. And histopathological examination was done to evaluate pathological changes. Results: Silymarin phytosome NPs with the mean size of 100 nm were produced and were well tolerated in cell culture. These NPs showed a considerable protective effect against ALD through inverting the biochemical parameters (ALP, ALT, AST, GGT, GPx) and histopathological alterations Conclusion: Silymarin phytosomal NPs can be used as an efficient treatment for ALD.
Exploratory data analysis of physicochemical parameters of natural antimicrobial and anticancer peptides: Unraveling the patterns and trends for the rational design of novel peptides
Authors: Saini Sandeep , Rathore Aayushi , Sharma Sheetal , Saini Avneet
Published: August 2023

Introduction: Peptide-based research has attained new avenues in the antibiotics and cancer drug resistance era. The basis of peptide design research lies in playing with or altering physicochemical parameters. Here in this work, we have done exploratory data analysis (EDA) of physicochemical parameters of antimicrobial (AMPs) and anticancer (ACPs) peptides, two promising therapeutics for microbial and cancer drug resistance to deduce patterns and trends. Methods: Briefly, we have captured the natural AMPs and ACPs data from the APD3 database. After cleaning the data manually and by CD-HIT web server, further data analysis has been done using Python-based packages, modlAMP and Pandas. We have extracted the descriptive statistics of 10 physicochemical parameters of AMPs and ACPs to build a comprehensive dataset containing all major parameters. The global analysis of datasets has been done using modlAMP to find the initial patterns in global data. The subsets of AMPs and ACPs were curated based on the length of the peptides and were analyzed by Pandas package to deduce the graphical profile of AMPs and ACPs. Results: EDA of AMPs and ACPs shows selectivity in the length and amino acid compositions. The distribution of physicochemical parameters in defined quartile ranges was observed in the descriptive statistical and graphical analysis. The preferred length range of AMPs and ACPs was found to be 21-30 amino acids, whereas few outliers in each parameter were evident after EDA analysis. Conclusion: The derived patterns from natural AMPs and ACPs can be used for the rational design of novel peptides. The statistical and graphical data distribution findings will help in combining the different parameters for potent design of novel AMPs and ACPs.
Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells
Authors: Shchegolev Yuri Yu. , Sorokin Danila V. , Scherbakov Alexander M. , Andreeva Olga E. , Salnikova Diana I. , Mikhaevich Ekaterina I. , Gudkova Margarita V. , Krasil’nikov Mikhail A.
Published: August 2023

Introduction: Resistance to chemotherapy and/or irradiation remains one of the key features of malignant tumors, which largely limits the efficiency of antitumor therapy. In this work, we studied the progression mechanism of breast cancer cell resistance to target drugs, including mTOR blockers, and in particular, we studied the exosome function in intercellular resistance transfer. Methods: The cell viability was assessed by the MTT assay, exosomes were purified by successive centrifugations, immunoblotting was used to evaluate protein expression, AP-1 activity was analyzed using reporter assay. Results: In experiments on the MCF-7 cell line (breast cancer) and the MCF-7/Rap subline that is resistant to rapamycin, the capability of resistant cell exosomes to trigger a similar rapamycin resistance in the parent MCF-7 cells was demonstrated. Exosome-induced resistance reproduces the changes revealed in MCF-7/Rap resistant cells, including the activation of ERK/AP-1 signaling, and it remains for a long time, for at least several months, after exosome withdrawal. We have shown that both the MCF-7 subline resistant to rapamycin and cells having exosome-triggered resistance demonstrate a stable decrease in the expression of DNMT3A, the key enzyme responsible for DNA methylation. Knockdown of DNMT3A in MCF-7 cells by siRNA leads to partial cell resistance to rapamycin; thus, the DNMT3A suppression is regarded as one of the necessary elements for the development of acquired rapamycin resistance. Conclusion: We propose that DNA demethylation followed by increased expression of key genes may be one of the factors responsible for the progression and maintenance of the resistant cell phenotype that includes exosome-induced resistance.
Poly (acrylic acid)/tricalcium phosphate nanoparticles scaffold enriched with exosomes for cell-free therapy in bone tissue engineering: An in vivo evaluation
Authors: Moradi Nahid , Zomorrod Mina Soufi , Hosseinzadeh Simzar , Soleimani Masoud
Published: August 2023

Introduction: This study aimed to assess the potential of poly (acrylic acid)/tricalcium phosphate nanoparticles (PAA/triCaPNPs) scaffold in terms of biocompatibility and osteoconductivity properties the in-vivo evaluation as well as to investigate the performance of PAA/triCaPNPs scaffold (with or without exosomes derived from UC-MSCs) for bone regeneration of rat critical-sized defect. Methods: PAA/triCaPNPs scaffold was made from acrylic acid (AA) monomer, N,N’-methylenebisacrylamide (MBAA), sodium bicarbonate (SBC), and ammonium persulfate (APS) through freeze-drying method. For in vivo evaluation, we randomly divided 24 rats into three groups. The rat calvarial bone defects were treated as follows: (1) Control group: defects without any treatment, (2) scaffold group: defects treated with scaffold only, (3) scaffold+exo group: defects treated with scaffold enriched with exosomes (1 μg/μl ,150 μg/per rat). Eight- and 12-weeks post-surgery, half of the animals were sacrificed and bone regeneration was examined through micro-computerized tomography (µ-CT), histological staining, and immunohistochemistry (IHC). Results: Quantitative analysis based on µ-CT scan images at 8 and 12 weeks post-implantation clearly indicated that healing rate for defects that were filled with scaffold enriched with exosome was significantly higher than defects filled with scaffold without exosome. The H&E and Masson staining results revealed that more new bone-like form developed in the scaffold+exo group than that in control and scaffold groups. Further, IHC staining for osteocalcin and CD31 confirmed that more bone healing in the scaffold+exo group at 12 weeks could be associated with osteogenesis and angiogenesis concurrently. Conclusion: In the present study, we aimed to investigate the therapeutic potential of PAA/triCaPNPs scaffold as a carrier of human UC-MSC-derived exosome to achieve the exosome-controlled release on calvarial bone defect. The in vivo results indicated that the exosome-enriched scaffold could effectively minify the defect area and improve the bone healing in rat model, and as such it could be an option for exosome-based therapy.
Studying Luminal, A and B subtypes of the breast cancer under paracrine secretion of fibroblasts
Authors: Jalilzadeh Nazila , Barzegar Barough Neda , Karami Mehrdad , Baghbanzadeh Amir , Velaei Kobra
Published: August 2023

Introduction Understanding the role of the tumor microenvironment in specifying molecule markers of breast cancer subtypes could involve tumor microenvironment properties in subtyping and clinical assessment of breast cancer. Therefore, interconversion of luminal states and or their specific markers alteration under the control of TME particularly CAFs deserve to be more investigated. Methods To activate normal human fibroblasts, liquid overlay technique or nemesis was used and α-SMA expression, CAFs marker, in fibroblastic spheroids was measured by blotting. The luminal A, MCF-7, and luminal B, MDA-MB 361, cell lines are treated with normal and spheroidal/activated fibroblast conditioned medium for 48 hours. The morphological changes of luminal A and B cells were evaluated by invert microscopy and analyzed by the shape factor formula. Moreover, sensitivity changes to chemotherapeutic agents, Ki67 expression, and gene expression level including ER-related and proliferative genes were assessed respectively by MTT assay, Immunofluorescence, and real time qRT-PCR methods. Results Activated fibroblast, spheroid form, by LOT/nemosis expressed α-SMA marker two folds more than monolayer cultured fibroblasts. Our study underlined a significant increase in IC50 of both luminal A and B cell lines after being co-cultured with conditioned medium markedly in spheroidal conditioned medium. Morphological changes study by shape factor formula demonstrated more aggressiveness with gaining mesenchymal features both in luminal A and B subtypes by increasing exposure time. Changes in Ki67 expression level were observed after fibroblasts and spheroidal paracrine conditioning. Only this data supports the luminal interconversion by elevated Ki67 expression in luminal A and lowered Ki67 expression in luminal B. Gene expression results revealed that the MCF7 and MDA-MB cells as representatives luminal A and B subtypes in this study did not interchange their own specific gene pattern, however both luminal types in co-culture with condition medium increased the expression of anti-apoptotic Bcl2 gene. Conclusion Under the paracrine influence of fibroblast cells, both luminal A(MCF7) and B (MDA-MB) subtypes of breast cancer gained invasive, anti-apoptotic, and chemoresistance features which are mostly increased by activated fibroblast conditioned medium mimicking CAFs. There was no strong proof for interconversion of luminal A and B, with more similarities, subtypes of breast cancer.
Spectroscopic aspects on the interaction of nisin with serum albumin: thermodynamic and kinetic studies
Authors: Azimirad Maryam , Javaheri-Ghezeldizaj Fatemeh , Soleymani Jafar , Ezzati Nazhad Dolatabadi Jafar , Torbati Mohammadali
Published: August 2023

Introduction: Nisin is a bacteriocin produced by Streptococcus and Lactococcus species and has antimicrobial activity against other bacteria. Nisin omits the need to use chemical preservatives in food due to its biological preserving properties. Methods: In the present in vitro study, we investigated nisin interaction with bovine serum albumin (BSA) using fluorescence spectroscopy and surface plasmon resonance (SPR) analysis to obtain information about the mechanisms of BSA complex formation with nisin. Results: The BSA fluorescence intensity values gradually diminished with rising nisin concentration. The BSA fluorescence quenching analysis indicated that a combined quenching mechanism plays the main role. Finally, the Kb values were reduced with increasing temperature, which is demonstrative of nisin-BSA complex stability decrease at high temperatures. The negative values of ΔH° and ΔS° showed that hydrogen bonds and van der Waals forces are the foremost binding force between BSA and nisin. Meanwhile, the negative values of ΔG° demonstrated the exothermic and random nature of the reaction process. The results of the SPR verified the gained results through the fluorescence spectroscopy investigation, which denoted that the BSA affinity to nisin diminished upon increasing temperature. Conclusion: Overall, fluorescence spectroscopy and SPR results showed that the BSA interaction with nisin decreased with rising temperatures.
Identification and Prioritization of Required Managerial Competencies for Healthcare Management Graduates in Iran Health System
Authors: Delavari Sajad , Barati Omid , Najibi Seyed Reza , Shahmohamadi Javad , Nikmanesh Parnian , Najibi Seyede Maryam , Delavari Somayeh
Published: August 2023

Background. Students and graduates in the field of health management will be future managers of the health field. Improving the skills of health system managers as one of the main pillars of health service organizations is essential to meet the health needs of the community. Therefore, this study aimed to identify and prioritize the key skills required by healthcare management graduates as future managers of the health system. Methods. This study was performed in three steps using the method of content analysis, Delphi, and factor analysis. In the first step, a semi-structured and interactive in-depth interview was used to determine the skills required for managerial jobs in the health system, and the data were analyzed based on the content analysis method. The sample size was 14 health experts. In the second step, a Delphi study was designed to build consensus on skills. The participants scored 44 skills extracted from the interviews through a three-point Likert scale from disagree to agree (from 1 to 3), then the skills were divided into several component groups through factor analysis. Results. In this study, 44 key skills needed by managers and graduated students in the field of health service management were identified in 10 components. Conclusion. Costs and resources allocated to the training of health service management graduated students should be based on the need of the labor market and workspace.
Modeling the Growth of Technology Units for Health Technology Incubators Suitable for Low-Income Areas
Authors: Hoseinnezhad Mehdi , Hamidi Naser , Mehrabi Javad
Published: August 2023

Background. This research aimed to optimize the technology policy and reduce the costs of technology growth centers at medical sciences universities. Identifying the effective factors in the expansion of technology units facilitates the development and advancement of innovative entrepreneurs through incubators. Methods. The current qualitative research analyzes data collected through structured interviews with 31 individuals from growth centers, administrators of units located in growth centers, and health entrepreneurship experts. In three stages of categorization, the main and sub-categories have been identified. The relationships between the research components were determined using the interpretive structural modeling (ISM) technique. Results. Based on the results of the ISM, "modeling of technology units for health technology incubators in poor areas" we identified 213 codes of verbal propositions, 25 components and 8 categories which was classified into three levels. The first level is the growth of technological units; the second level includes the infrastructure and planned growth; and the third level includes the indicators of external infrastructure, internal infrastructure, acceptance plan, growth plan, and exit plan. Conclusion. This study determined the framework and relationships between variables that influence the growth of technology units in health technology development centers at universities in disadvantaged areas. This is the first study to incorporate the internal infrastructure as an independent variable, indicating the effect of compensating for regional infrastructure weaknesses.
Bioactivity Assays of Eryngium thyrsoideum; Focusing on Cytotoxic Effects, Antioxidant Activity, and Antimalarial Properties
Authors: Sardari Keyvan , Delazar Abbas , Asnaashari Solmaz , Asgharian Parina
Published: August 2023

Background: The genus Eryngium, Apiaceae is widely distributed in the world and used in traditional medicine for different therapeutic purposes. Eryngium thyrsoideum was investigated due to a lack of phytochemical studies on the probable bioactivities of its compounds. Methods: The aerial parts of the plant were extracted using n-hexane, dichloromethane, and methanol (MeOH) by the soxhlet method. The MeOH extract was exposed to C18 Sep-Pak fractionation by a step gradient of MeOH-H2 O. The essential oil was obtained by the Clevenger apparatus. Free-radical scavenging activity of the extracts and fractions was assessed using the DPPH-scavenging activity method. Total flavonoid content was determined by Aluminum chloride colorimetric and phenolic content was determined by using the Folin-Ciocalteu reagent method. α-Glucosidase inhibitory and antimalarial activity of extracts and essential oil and cytotoxic activity of essential oils was also established in this study. Results: The 20% solid phase extraction fraction demonstrated high antioxidant activity (0.13±0.01 mg/mL) and also indicated the most total flavonoid and total phenolic contents (474.20±23.11 and 27.90±0.55 mg/100 g) respectively, in comparison to other fractions. We observed a moderate β-Hematin Formation Assay inhibitory effect of the essential oil (10.37±0.02 mg/mL) and DCM extract (7.64±0.01 mg/mL). Low levels of α-glucosidase inhibition were observed in n-hexane extract (9.78±1.1%) and essential oil of aerial parts (2.7±1.1%). Cytotoxic activity for the essential oils is confirmed by representing respectively IC50 with 2.51 mcg/mL and 1.07 mcg/mL in 24 and 48 hours in MCF-7 cell lines. Conclusion: The presence of phenolic compounds and flavonoids in MeOH extract and fractions is effective on the antioxidant potency of E. thyrsoideum. Essential oil of this plant presented noticeable effects on human breast cancer cell lines.
The Effect of Aromatherapy withCitrus aurantiumAroma on Pain after Orthopedic Surgery: A Randomized Clinical Trial
Authors: Bargi Sepideh , Bahraminejad Nasrin , Jafari Samineh , Fallah Ramezan
Published: August 2023

Introduction: Postoperative pain is one of the most common physiological and psychological stress in patients that disrupts body function and can endanger patients’ health. This study aims to determine the effect of aromatherapy with Citrus aurantium essential on pain after orthopedic surgery. Methods: This randomized clinical trial was performed on 60 candidates for orthopedic surgery. Patients were selected through convenience sampling and divided into intervention and control groups through randomized block allocation. If the visual analogue scale (VAS) score was above 3, patients in the intervention group received aromatherapy with C. aurantium essential and the patients in the control group received a placebo (almond oil). VAS was used to measure pain. Data analysis was performed using independent t test, paired t test, and analysis of variance with repeated measures using SPSS software version 13. Results: Mean (SD) of pain intensity after intervention in experimental and control groups within 4, 8, and 12 hours after surgery was 7.30 (1.23) vs. 7.90 (0.99), 5.30 (0.98) versus 5.53 (0.68) and 2.53 (0.9) vs. 3.60 (0.77) respectively. The findings indicated that there was a significant difference in mean pain intensity between the experimental and control groups at 4 and 12 hours after surgery. Use of analysis of variance with repeated measures test with taking into account the interaction of time and group also showed a significant difference in mean pain intensity between the two experimental and control groups. Conclusion: Aromatherapy with Citrus aurantium essential can be effective in reducing mild to moderate pain after orthopedic surgery. Further studies are recommended to confirm this finding.
The Relationship between COVID-19 Exposure Risk and Burnout in Prehospital Emergency Medical Technicians
Authors: Javanmardi Karim , Gilani Neda , Ghafourifard Mansour , Dadashzadeh Abbas , Dehghannejad Javad , Feyzollahzade Hossein
Published: August 2023

Introduction: Exposure to coronavirus disease 2019 (COVID-19) has caused many physical and psychological effects on front-line healthcare workers (HCWs). This study aimed to assess the relationship between the exposure risk to COVID-19 disease and burnout in prehospital emergency medical technicians (EMTs). Methods: In this correlational study, 335 prehospital EMTs were selected by random sampling method from the 49 stations of emergency medical services in the northwest of Iran. Data were collected using a questionnaire developed by the world health organization for the risk assessment and management of exposure of health care workers to COVID-19. Moreover, Pines burnout measure was used for the assessment of participants’ burnout. Data were analyzed using SPSS version 13. Results: Results showed that 30.7 % of prehospital EMTs had a high burnout score against COVID-19 disease. The prehospital EMTs who had a high occupational exposure risk experienced a high risk of burnout (P=0.03). The results of the linear regression analysis showed that prehospital EMTs who had a low exposure risk of COVID-19 had a low burnout score (β=-9.30; P<0.001), and those who had less than 10 years of work experience showed less burnout (β=-10.54; P<0.001). Conclusion: According to the results, the exposure risk to COVID-19 increases the prehospital EMT’s burnout. As a result, reducing the exposure risk to COVID-19 by providing adequate access to personal protective equipment (PPE), development of training and following standards and protocols can be effective in controlling burnout in HCWs.
Psychometric Properties of the Greek Version of Demoralization Scale-II (DS-II) in Patients with Cancer
Authors: Elmasian Tania-Flora , Nikoloudi Maria , Tsilika Eleni , Kostopoulou Sotiria , Zygogianni Anna , Katsaragakis Stylianos , Mystakidou Kyriaki
Published: August 2023

Introduction: The concept of demoralization is used to describe situations of existential distress and self-perceived inability to effectively deal with stressors. The Demoralization Scale-II (DS-II) is a short and modified version of the original DS that measures the level of demoralization in patients. The purpose of this study is to evaluate the psychometric properties of the Greek version of the Greek Demoralisation Scale-II (DS-II GR) in the population of patients with cancer. Methods: The main tool used in this cross-sectional study is the DS-II GR translated and evaluated for its psychometric properties in a sample of 150 Greek patients with cancer. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), convergent validity, known groups’ validity, cut-off points, internal consistency reliability and test-retest reliability were done. Results: According to the CFA, a two-factor model emerged with a different conceptual content and grouping than the original. The correlation coefficients between DS-II GR and Hospital Anxiety and Depression Scale-Greek (HADS-GR) The internal consistency of DS-II GR for factor 1, factor 2, and total score were measured with Cronbach’s alpha and calculated to be 0.906, 0.810, and 0.913. Conclusion: The Greek version of the demoralization scale is reliable and valid for assessing demoralization in Greek patients with cancer.
A comparative study on public, social, academic and family self-esteem in students with and without ADHD
Authors: Amiri Shahrokh , Ahmadi Parichehr , Alivandi Vafa Marziyeh , Zakeri Ebrahim
Published: August 2023

Background. Considering the importance of self-esteem as an influential variable in the mental health of children with Attention Deficit Hyperactivity Disorder (ADHD) and also the inconsistent findings in the related literature, this study intended to compare the level of self-esteem in public, social, academic, and family contexts in students with and without ADHD. Methods. The research design was based on the causal-comparative study. The intended first population of this study consisted of students with ADHD who had visited the child and adolescent psychiatry clinic of Razi Hospital in Tabriz during 2021 (1400 in the solar calendar); the second population was made up of healthy counterparts of this clinical group (i.e., students without ADHD). Based on the purposive sampling method, 48 students who were diagnosed with ADHD without co-occurring psychiatric disorder by a child psychiatry specialist were selected as the study group. Also, 48 healthy students from Tabriz schools were selected as the group without ADHD. Results. Given the obtained results, a statistically significant difference was found between the ADHD group and the non-ADHD group in light of the composite scores of the self-esteem sub-components. The findings showed a statistically significant difference between the two groups in terms of the public and the family subscales, that is, the public self-esteem of the group with ADHD was higher than the mean of the general self-esteem of the non-ADHD group, and the mean of the family self-esteem of the non-ADHD group was higher than that of the ADHD group. However, there was no significant difference between the two groups in terms of the social and academic subscales. Conclusion. Based on the findings, it was concluded that the self-esteem of students with ADHD in their inner world is different from other individuals’ inferences about the self-esteem of these children. In other words, these children had acceptable self-esteem in their psychological world according to their psychological conditions. In addition, considering the low family self-esteem of the participants with ADHD, the behavioral quality of these children’s parents and relatives may have affected how they define family relationships and consequently, lowered their value. Practical Implications. Considering the obtained results, it was suggested to pay attention to these children’s self-esteem in their interventions and use the potential of this variable in controlling individual and family behaviors.
Relationship Between Smart Cities and Smart Tourism: Using a Systematic Review
Authors: Sarji  , Riza Chakim Mochamad Heru , Hatta Muhammad , Himki Arzo , Rahmania Az Zahra Achani , Nur Azizah Nadia
Published: August 2023

Smart City and Smart Tourism have gained popularity in recent years, but research in Smart Tourism Cities has not fully covered their development. This study aims to explore the latest literature on Smart City and Smart Tourism, examining their roles in achieving sustainable and competitive tourism through advanced design. The study presents the relationship between Smart City and Tourism, mapping the current situation and potential growth of Asian tourism through Smart Cities. Recent studies show that Smart Cities play a crucial role in developing tourist destinations. Smart Tourist Cities result from the convergence of Smart and Tourist Cities, using technology to improve the quality of life, urban services, and meet social, cultural, and economic needs. Limitations include a narrow scope, only covering research articles on Google Scholar, and not covering other literature aspects such as authorship, co-writing, big data, and virtual reality.
АНАЛІЗ ЗАХВОРЮВАНОСТІ НА КАРІЄС ЗУБІВ У ДІТЕЙ ТА ПІДЛІТКІВ ІЗ ПСИХОНЕВРОЛОГІЧНИМИ РОЗЛАДАМИ
Authors: Кошкін О.Є. , Петрунів В.Б. , Лабій Ю.А. , Рожко В.І. , Рожко О.В.
Published: August 2023

Мета дослідження. Вивчення поширеності та інтенсивності карієсу у дітей та підлітків із психоневрологічними розладами, що проживають в будинках-інтернатах Снятинського району Івано-Франківської області. Методи дослідження. Для вирішення завдань дослідження та реалізації його мети було проведено стоматологічне клінічне обстеження вихованців психоневрологічних інтернатів м. Снятин та с. Долішнє Залуччя Івано-Франківської області. Загалом було обстежено 257 осіб віком 6–15 років із різними психоневрологічними розладами. Проведено індексну оцінку стану твердих тканин зубів. Наукова новизна. Моніторинг даних стоматологічного обстеження 257 дітей, у загальному анамнезі яких були психоневрологічні захворювання, показав, що у 96,49±1,93% обстежених виявлено карієс з переважанням декомпенсованої форми. Звертало увагу, що поширеність карієсу у хлопців та дівчат, у середньому, була практично одинаковою 96,59±2,85 та 96,36±2,60% відповідно. Максимальні значення поширеності карієсу досліджували у віковій групі 13–15 років, яка дорівнювала 100%. Стосовно інтенсивності карієсу зубів, індекс КПВ, у середньому, трактувався як високий зі значенням 11,46±0,15. Висновки. Встановлено факт високої поширеності та дуже високої інтенсивності карієсу зубів у дітей та підлітків із психоневрологічними розладами. Поширеність карієсу зубів у обстежених дітей різних вікових груп із психоневрологічними розладами наближалася до 100 %.
Hemşirelik Öğrencilerinin Özyeterlilik Algıları, Sağlık Okuryazarlığı Düzeyleri ve Etkileyen Faktörler
Authors: KAÇKİN Özlem , KILIÇ Medine , ERSİN Fatma
Published: August 2023

Amaç: Bu araştırmanın amacı, hemşirelik öğrencilerinin özyeterlilik ve sağlık okuryazarlığı düzeylerini ve etkileyen faktörlerini incelemektir. Materyal ve metod: Çalışma, 01-11 Kasım 2022 tarihleri arasında bir kamu üniversitesine bağlı hemşirelik bölümünde yapılmıştır. Tanımlayıcı tipte olan çalışmanın evreni 627 öğrenci, örneklemini ise 519 (%82,7) öğrenciden oluşmuştur. Veriler, yüz yüze görüşme tekniği ile toplanmıştır. Araştırmacılar tarafından hazırlanan tanıtıcı bilgi formu, Genel Yeterlilik Ölçeği ve Sağlık Okuryazarlığı Ölçeği veri toplama araçları olarak kullanılmıştır. Verilerin analizinde tanımlayıcı istatistikler, bağımsız gruplarda t testi, Mann Whitney U Testi, Varyans Analizi, Kruskal Wallis Analizi ve Korelasyon Analizi yapılmıştır. Çalışmaya başlamadan önce, etik kuruldan, kurumdan ve katılımcılardan izin alınmıştır. Bulgular: Öğrencilerin yaş ortalaması 21.10±2.59 olup, %70,5’i kadın, %63’ünün geliri giderinden azdır. Katılımcıların %51,3’ü sağlığını orta düzeyde algıladığını, %7,9’u kronik hastalığı oluğunu, %4,4’ü ruhsal sorunu olduğunu, %13,1’i sigara kullandığını, %19.5’i alkol aldığını, %74.2’si düzenli egzersiz yaptığını belirtmiştir. Öğrencilerin özyeterlilik ölçeği puan ortalaması 52.07±3.18, sağlık okuryazarlığı ölçeği puan ortalaması 102.94±16.95’tir. Çalışmaya katılan kadınların özyeterlilik ölçeği puan ortalaması (t=2.695, p=.007) ve sağlık okuryazarlığı ölçeği puan ortalaması (t=4.719, p=.000) anlamlı bir şekilde yüksek çıkmıştır. Egzersiz yapan öğrencilerin özyeterlilik ölçeği puan ortalaması (t=-2.026, p=.043) ve sağlık okuryazarlığı ölçeği puan ortalaması (t=4.496, p=.000) anlamlı bir şekilde yüksek bulunmuştur. Özyeterlilik ölçeği ile sağlık okuryazarlığı ölçeği arasında negatif yönde çok zayıf düzeyde anlamlı bir ilişki olduğu belirlenmiştir (r=.-114, p=.010). Sonuç: Öğrencilerin özyeterlilik ve sağlık okuryazarlığı düzeylerinin istenen düzeyde olmadığı görülmektedir. Öğrencilerin özyeterlilik ve sağlık okuryazarlığı düzeylerini arttıracak girişimsel hemşirelik çalışmaları önerilmektedir.
CRM in Architecture: Data Collection of Customized Repetitive Manufacturing Case Studies Analyzed
Authors:   North Carolina State University, Gulling Dana K.
Published: August 2023

In architecture, computer-aided manufacturing (CAM) and computer numerical controlled (CNC) equipment has revolutionized the relationship between design and fabrication. Directly, CNC equipment can cut, carve, and shape materials to fabricate architecture components; indirectly, CNC equip¬ment can cut, carve, and shape custom tools (e.g. molds, patterns, and jigs) to manufacture architecture components. With its indirect use, CNC equipment has made it affordable and practical to customize repetitive manufacturing (CRM) on a per-building basis. For many processes and projects, CRM offers a wider range of component materials, with less manufacturing waste, in less time, and for less money than directly manufacturing with CAM. We have collected over 340 examples of CRM in architecture. Our examples are located around the world and demon-strate a global application of CRM in architecture. Our CRM example data includes project year completed; architect; building location, size, type, and budget; and categorizes the CRM component types, manufacturing processes, materials, production runs, and the number of produced variants. Using the data visualization software Tableau, this paper presents and analyzes our CRM data.
SPATIAL FUTURES STUDIO: Cooperative MR Design-Production
Authors:   Georgia Institute of Technology, Kaseman Keith
Published: August 2023

Milgram and Kishino define mixed reality (MR) through theirconcept of a “virtuality continuum” that spans between realand virtual environments, wherein display technologies areconfigured to combine real objects and computational models.1 With augmented reality (AR) towards one end of thisfoundational spectrum and virtual reality (VR) establishing theother, Azuma defines AR as real-time systems that combinethe real and virtual, with registration in three-dimensionalspace.2 Generally, MR applications utilize location-specificinformation for spatial registration.3
Entangled: A Studio Project Building Ecology
Authors:   University at Buffalo and Carnegie Mellon University, Garofalo Laura
Published: August 2023

Our identity as architects is still bound with the image of nature that places architecture and other human constructs strictly outside of a “wild” nature that is pure, vibrant, and untamed. This has resulted in nostalgic, exclusionary eco-narratives that curtail the architectural imagination. Understanding our role as part of an evolving ecology and its omnipresent human influence has the potential to rein¬vigorate the practice. Coexisting as interdependent entities (both physical and conceptual), landscape and technology can define built form that imagines productive and healthy infrastructures for a collective ecology. This paper describes the first of a set of studios run by the University at Buffalo School of Architecture and Planning Ecological Practices Graduate Research Group, its collabora¬tion with a parallel techniques course, and a local partner and the design build project it initiated, Silo City Trellis. The studio explored how to formulate an eco-centric identity through small scale architectural interventions, garden struc¬tures that literally and figuratively entwine themselves with the local ecology of a site that is at once a burgeoning “urban wild” and a monument to the city’s post-industrial heritage. This apparently wild site is in fact a garden. Maintained and curated, it highlights the effort it takes to maintain a “natu¬ral” environment in the highly synthetic urban context. The architecture of the garden makes it into an interface where the boundaries between nature and the man-made are perpetually negotiated providing a pedagogical model that proposes alternative ideologies about our ecosystems-both environmental and socio-political. Silo City Trellis is a combined structure and landscape regen¬eration system that literally entwines architecture earth and vegetation. Emulating the work of the site’s Director of Ecology the growing infrastructure aims to suggest ecocentric solutions for the future of cities by pushing the boundaries of architecture as a provider of ecosystem services and social stewardship. The proposal envisions that in a post-nature environment architecture can play a role not only in societal enlightenment but also in the intentional cultivation and stewardship of biological ecologies.
Transforming the Design Studio to Achieve Net-Zero Ready Buildings Annual Meeting Proceedings
Authors:   Thomas Jefferson University, Fleming Robert
Published: August 2023

In the fight against climate change, incremental improvements to the architectural design studio are no longer sufficient. The traditional studio model, which features a master/apprentice relationship, is well suited to generating “good” design solutions. However, this self-driven discovery-based learning process leaves little time or focus for achieving specific high-performance design strategies. More specifically, the traditional design studio features a distinct lack of accountability for performance-based metrics, a lack of time to pursue performance-based goals, a lack of priori¬tization of building performance, a lack of clarity for what constitutes a successful sustainable design process; and a lack of examples on “how to” perform simple design steps. As a response, a new studio pedagogy is proposed to assist students to achieve net-zero performance within the typi¬cal 15-week semester. A structured collection of sustainable design approaches specifically organized by a pyramid (Figure 1) helps professors and students adopt an over arch¬ing framework for sustainable design. This paper will focus specifically on the studio methodology itself. This new design methodology formalizes activities already used in the design studio and leads students to reach higher levels of build¬ing performance for their projects. Specifically, this paper will focus on the following innovative teaching techniques: How to place “accountability” into the design studio through early and often against well-established benchmarks; How to prioritize building performance by front-loading sustain-able design techniques; How to accelerate the design process through the use of “how-to” videos; and How to develop and use well-developed rubrics with learning objectives to keep students focused on both net-zero energy AND the more rewarding and more familiar design resolution process. In conclusion, this paper will spark a much-needed conversation on how design studio pedagogy itself can evolve to train students to design high-performance projects in the short-term and ultimately to mitigate the impacts of climate change in the long-term.
How do Students Reason about Statistical Sampling with Computer Simulations? An Integrative Review from a Grounded Cognition Perspective
Authors: Gök Sebahat , Goldstone Robert
Published: August 2023

Interactive computer simulations are commonly used as a pedagogical tool to support students’ statistical reasoning. However, whether and how these simulations enable the intended effects remain unclear. Here, we review the literature on students’ reasoning about statistical sampling through simulations. The findings suggest tentative benefits of the simulations in terms of building statistical habits of mind. However, challenges remain persistent when more specific concepts and skills are investigated. Students have difficulty forming an aggregate view of data, interpreting sampling distributions, showing a process-based understanding of the law of large numbers, making statistical inferences, and context independent reasoning. From a grounded cognition perspective, we discuss the roles of repeated practice, specific design elements, and guidance of visual routines for supporting students’ meaning-making from simulations. Finally, we propose testable instructional strategies for using simulations in statistics education. Overall, the paper illuminates the underlying cognitive processes of reasoning about statistical sampling and offers a set of concrete pedagogical considerations that future empirical studies can test.
Faktor Prognostik pada Efusi Pleura Ganas Berdasarkan Skor LENT di RSUP Prof. Dr. R. D. Kandou Manado
Authors: Tilaar Enika , Tangkilisan Adrian , Tamburian Christha , Korompis Grace
Published: August 2023

Abstract: As a complication of cancer, malignant pleural effusion (MPE) is related to varied life expectancy. LENT score is the first validated score in malignant pleural effusion. This study aimed to obtain factors affecting the MPE based on LENT score at Prof. Dr. R. D. Kandou Hospiptal, Manado. This was a prospective study with a cross sectional design Subjects were patients with MPE admitted to Prof Dr. R. D. Kandou from January to November 2022. The results obtained 30 MPE patients consisting of 50% males and 50% females with a mean age of 52 years. There were 22 patients with LDH level <1,500 IU/L dan eight patients with LDH level >1,500 IU/L. Based on ECOG score, there were three patients with score 1, seven patients with score 2, and 20 patients with score 3-4. There were 13 patients with NLR <9 and 17 patients with NLR >9. Lung cancer was the most common cancer causing MPE, followed by gynaecological cancer and breast cancer. Based on LENT score, there were 20 patients with high risk, 10 patients with moderate risk; no patients with low risk. In conclusion, LENT score can be used as prognostic score in patients with malignant pleural effusion.
Keywords: malignant pleural effusion; LENT score; complication of cancer
 
Abstrak: Efusi pleura ganas (EPG) merupakan komplikasi dari kanker dan dihubungkan dengan dengan angka harapan hidup yang bervariasi. Skor LENT merupakan skor tervalidasi pertama yang digunakan pada efusi pleura ganas. Penelitian ini bertujuan untuk menggambarkan faktor-faktor yang berperan pada EPG berdasarkan skor LENT di RSUP Prof. Dr. R. D. Kandou Manado. Penelitian prospektif cross sectional dari pasien dengan EPG di RSUP Prof Dr. R. D. Kandou Manado (Januari hingga November 2022). Pada penelitian ini didapatkan 30 pasien EPG (50% laki-laki; 50% perempuan) dengan rerata usia 52 tahun. Terdapat 22 pasien dengan kadar LDH di bawah 1.500 IU/L dan delapan pasien dengan kadar LDH di atas 1.500 IU/L. Berdasarkan skor ECOG, terdapat 3 pasien dengan skor 1, 7 pasien dengan skor 2, dan 20 pasien dengan skor 3-4. Terdapat 13 pasien dengan nilai NLR di bawah 9 dan 17 pasien dengan nilai NLR di atas 9. Kanker paru merupakan tipe tumor paling sering menyebabkan efusi pleura ganas, diikuti kanker ginekologi dan kanker payudara. Berdasarkan skor LENT terdapat 20 pasien dengan resiko tinggi, 10 pasien dengan resiko sedang, dan tidak ada pasien dengan resiko rendah. Skor LENT berperan sebagai skor prognostik pada pasien dengan EPG.
Kata kunci: efusi pleura ganas; skor LENT; komplikasi kanker