bluuebunny/crossref_metadata_2025 huggingface dataset:
User Behavior in Social Networks Toward Privacy and Trust: Literature Review
Authors: Almogbel Razan Saleh , Alkhalifah Ali Abddulaziz
Published: January 2022

Social networks (SNs) have become a significant part of daily life. It has become one of the most effective ways in which people communicate with each other. Huge amounts of data are generated and shared through SNS worldwide, where users share their personal and sensitive information. Therefore, disclosure of private information or identity and the loss of trust among users are among the most prominent and widespread privacy concerns. The main target of this study is to investigate the relationship between privacy, trust, and their effects on user behavior on Social networks. It provides a detailed and overall overview of the concepts and methods related to protecting the privacy and enhancing trust in Behavioral SNs users. In addition, it illustrates many of the key aspects of the research in the context of identity privacy and trust in users’ behavior on SNs and shows the most important restrictions and gaps that have been found and guidance on future research directions.
L’architecture interstitielle des Mémoires
Authors: Baty-Delalande Hélène
Published: January 2022

L’étude du récit de genèse que comportent, en leurs marges, les volumes des Mémoires de Beauvoir et l’analyse des campagnes d’écriture successives dont témoignent les avant-textes qui subsistent permettent de saisir un processus de composition complexe, qui estompe et redistribue ces fragments apparaissant d’abord comme des jalons réflexifs de l’écriture de soi. L’estompage du récit de genèse ou des moments de ressaisie réflexive du geste mémoriel peut être compris comme une manière de garantir la fluidité, la cohésion et la force d’évidence du récit récapitulatif. Ce qui subsiste n’est cependant pas à considérer comme un résidu : disposés aux différents seuils du récit, à ses interstices, les moments réflexifs contribuent alors à mettre en ordre le passé.
Appendix | Attracting Highly Skilled Migrants to Guangzhou, China: A Policy Commentary
Authors: Li Wei , Ma Ling , Tan Yining , Liu Meixin
Published: January 2022

Appendix to the chapter Wei Li, Ling Ma, Yining Tan and Meixin Liu (2022) Attracting Highly Skilled Migrants to Guangzhou, China: A Policy Commentary, International Development Policy | Revue internationale de politique de développement 14 | 2022, URL: http://journals.openedition.org/poldev/4825
Sexual Behaviour and Correlates for Risky Sexual Behaviour among Youth Attending Government Vocational Training Institutes in Colombo District
Authors: Siriwardena L. N. , Abeygunasekera N.
Published: January 2022

Background: Youth represent a proportion of the population most exposed to Sexually Transmitted Infections. The study of sexual behaviour patterns and what factors predisposes them for risky sexual behaviour is important in designing targeted interventions for youth.
Objective: To describe socio demographic profile, knowledge on STI, HIV and sexual health and information sources, sexual behaviour and correlates for risky sexual behaviour among youth aged 18-24 years in government vocational training institutes in Colombo District.
Method: Calculated sample size was 420. Stratified random sampling was used to enroll participants. Data was collected through a self-administered questionnaire. Data was analyzed using percentages, chi square test and logistic regression.
Results: Just over half (52%) the sample were males and all had completed Ordinary level examination or beyond. Twenty-five percent of the respondents were sexually active. Nearly 69% had not used a condom at their last sex. Ten percent of males who were sexually experienced had anal sex at their first sexual exposure. Gender, ability to earn, knowledge on STI prevention and contraception, using pornography in the last 12 months and social media to find partners were associated with ever having sex. Male sex and ability to earn were positive predictors of ever having sex and contraceptive knowledge was a negative predictor.
Conclusions: Risky pre-marital sex is present among this study sample. Male sex and ability to earn were positively predictive of ever having sex. Knowledge on contraception was negatively predictive.
HIV Testing and Receiving Test Results by the Female Sex Workers; Retrospective Study using Data from Sri Lanka National HIV Prevention Programme
Authors: Suranga M. Suchira , Samita S. , Karawita D. A.
Published: January 2022

Introduction: Improving HIV testing among Key Populations (populations at high risk) is the first step to achieve 90:90:90 treatment targets. Studying the time taken to HIV testing and subsequent clinic visits to uptake the test results provide important inputs for development of HIV prevention programmes.
Objectives: This study aims to understand the pattern of HIV testing behavior of Female Sex Workers (FSWs) over the time and provide recommendations for development of HIV prevention programmes for FSWs
Methods: HIV testing data of 5,667 FSWs registered with national HIV prevention programme in 10 Districts of Sri Lanka during 2016 and 2017 were analyzed using, survival data analysis techniques and extended Prentice, Williams & Peterson (PWP) gap time model.
Results: Time taken to acceptance of HIV test is more dependent on individual factors of FSWs whereas uptake of test result is less dependent on individual factors. Youth FSWs take more time to accept an HIV test. FSWs who are operating in Districts out of Colombo, use condoms, reported undergone HIV testing before join the programme, take more time for HIV testing and uptake test results. FSWs with high partner exchange rate (therefore at high risk) are less likely to complete both events and take more time for testing. Interaction between FSW typology and condom use was found with the use of PWP model.
Conclusion: High risk FSWs are more reluctant for HIV testing and uptake of test results. Factors identified in the study as associated with time taken for both events can be taken into account in planning future HIV preventions programs among FSWs.
Variegated Outcomes of T Cell Activation by Dendritic Cells in the Steady State
Authors: Bourque Jessica , Hawiger Daniel
Published: January 2022

Conventional dendritic cells (cDC) control adaptive immunity by sensing damage- and pathogen-associated molecular patterns and then inducing defined differentiation programs in T cells. Nevertheless, in the absence of specific proimmunogenic innate signals, generally referred to as the steady state, cDC also activate T cells to induce specific functional fates. Consistent with the maintenance of homeostasis, such specific outcomes of T cell activation in the steady state include T cell clonal anergy, deletion, and conversion of peripheral regulatory T cells (pTregs). However, the robust induction of protolerogenic mechanisms must be reconciled with the initiation of autoimmune responses and cancer immunosurveillance that are also observed under homeostatic conditions. Here we review the diversity of fates and functions of T cells involved in the opposing immunogenic and tolerogenic processes induced in the steady state by the relevant mechanisms of systemic cDC present in murine peripheral lymphoid organs.
Minimal Information about MHC Multimers (MIAMM)
Authors: Vita Randi , Mody Apurva , Overton James A , Buus Soren , Haley Stephen T , Sette Alessandro , Mallajosyula Vamsee , Davis Mark M , Long Dale L , Willis Richard A , Peters Bjoern , Altman John D
Published: January 2022

With the goal of improving the reproducibility and annotatability of MHC multimer reagent data, we present the establishment of a new data standard: Minimal Information about MHC Multimers (https://miamm.lji.org/). Multimers are engineered reagents composed of a ligand and a MHC, which can be represented in a standardized format using ontology terminology. We provide an online Web site to host the details of the standard, as well as a validation tool to assist with the adoption of the standard. We hope that this publication will bring increased awareness of Minimal Information about MHC Multimers and drive acceptance, ultimately improving the quality and documentation of multimer data in the scientific literature.
Kidney and lung in pathology: mechanisms and clinical implications
Authors: Satta Ersilia , Alfarone Carmelo , De Maio Alfonso , Gentile Sandro , Romano Carmine , Polverino Mario , Polverino Francesca
Published: January 2022

There is a close, physiological, relationship between kidney and lung that begin in the fetal age, and is aimed to keep homeostatic balance in the body. From a pathological point of view, the kidneys could be damaged by inflammatory mediators or by immune-mediated factors linked to a primary lung disease or, conversely, it could be the kidney disease that causes lung damage. Non-immunological mechanisms are frequently involved in renal and pulmonary diseases, as observed in chronic conditions. This crosstalk has clinical and therapeutic consequences. This review aims to describe the pulmonary-renal link in physiology and in pathological conditions.
Analysis of microstructural changes in an X-linked juvenile retinoschisis patient harboring RS1 G668A mutation by en-face optical coherence tomography imaging
Authors: Mishra Chitaranjan , Duvesh Roopam , Chowdhury Susmita , Anjanamurthy Rupa , Kannan Naresh Babu , Ramasamy Kim , Sundaresan Periasamy
Published: January 2022

Juvenile X-linked retinoschisis (JXLR) is an X-linked recessive retinal dystrophy caused by retinoschisin (RS1) gene mutations. The current study reports and describes the cumulative findings of en-face OCT for a 7-year-old JXLR patient harboring a hemizygous pathogenic RS1 mutation (c.G668A; p.Cys223Tyr), where residue 223 is vital for cellular adhesion. Fundoscopy showed cart-wheel appearance at macula. Further, en-face OCT revealed characteristic schitic lesions in the ganglion cell layer, inner plexiform layer, inner nuclear layer, and outer plexiform layer. Our report adds to the Indian RS1 mutation spectrum and casts insights into the schisis microstructure using en-face imaging.
Inadvertent globe penetration due to self-attempted eyeball tattooing
Authors: Shalini Bagavath , Velayudhan Nair Arjun , Periasamy Mangala , Kumarswamy Karan , Dsouza Palmeera N J
Published: January 2022

Eyeball tattooing or scleral tattooing is a new form of body modification. A 27-year-old Indian male presented with defective vision in the left eye a day after self-attempted eyeball tattooing. The inadvertent penetration and ink injection led to the staining of the cornea, suspension of ink in the aqueous. The lens showed capsular staining and subsequent progression to the cataract. The posterior segment showed staining of vitreous with the red dye, retinal thickening at the macula. The optical coherence tomography showed inner retinal hyperreflectivity with retinal thickening. As these “Do it yourself” maneuvers are becoming trends influenced by social media, we report a case of self-attempted eyeball tattooing and its complications.
Three branches involvement in retinal vein occlusion
Authors: Abdi Fatemeh , Abdolalizadeh Parya , Zand Amin , Gordiz Arzhang , Sardarinia Mahsa , Motevasseli Tahmineh
Published: January 2022

Two patients presented with sudden painless unilateral blurry vision. The first patient was a 57-year-old female, and the second was a 71-year-old male. The medical history of the first patient was significant for diabetes mellitus and systemic hypertension. Funduscopy of both revealed an unusual form of RVO, occlusion of three main veins of the retina, with concomitant intraretinal hemorrhages, and macular edema. An extensive ischemic retina was found in the fluorescein angiography of the second patient. Retinal vein occlusion can present as three main veins occlusion in some patients due to rare anatomic variation.
Inadvertent ocular perforation with hypodermic needle during saline irrigation
Authors: Kumarswamy Karan , Nair Arjun Velayudhan
Published: January 2022

We present a case of globe perforation with hypodermic needle during saline irrigation. A 24-year-old presented with sudden onset defective vision during saline wash in his left eye. Patient on examination had hypotony and mild lid edema. Scleral wound was only apparent after staining; rest of the anterior segment was within normal limits. Posterior segment showed vitreous hemorrhage with retinal tear nasal to disc and adjacent commotio retinae. Patient was given tapering topical antibiotic steroid eye drops and kept under close observation. On his final follow-up 6 weeks after the initial injury, vitreous hemorrhage was resolving; the retinal tear had scarred with a choroidal rupture. Hypodermic-needle injuries are often complicated by the development of endophthalmitis. Our patient did not develop endophthalmitis, possibly due to the needle being sterile. He regained good vision and was saved from devastating consequences as the needle had missed the disc by a few millimeters.
A rare case of myelin oligodendrocyte glycoprotein antibody disease with keratoconus
Authors: Makkar Sunny , Ahuja Nisha , Khandelwal Sonal
Published: January 2022

Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) consists of a group of inflammatory demyelinating disorders generally associated with optic neuritis and acute disseminated encephalomyelitis (ADEM). We present a case report of MOGAD, who along with optic neuritis and seizures was detected to have keratoconus. No association of keratoconus with this condition has been documented in the literature. The presence of keratoconus is just an incidental finding or has an association with MOGAD needs to be ascertained by studies and documentation of similar cases. Further data need to be collected to establish any association between the two.
A case of double hypopyon secondary to Serratia keratitis after penetrating keratoplasty
Authors: Kumar Ajit , Khurana Ashi , Sharma Mohit
Published: January 2022

We report a case of a 39-year-old male who underwent therapeutic penetrating keratoplasty in his left eye. Three weeks after the procedure, he presented with complaints of blurred vision, redness in the eye, and ocular pain after trauma by insect bite four days back. Slit-lamp examination revealed central epithelial defect with deep stromal infiltrate accompanied by a double hypopyon. Serratia sp. was isolated on cultures. Serratia marcescens was confirmed on the VITEK 2 system. Isolated organism was sensitive to imipenem. Fortified imipenem 1% eye drop was started on a half-hourly basis. At six weeks follow-up, resolving infiltrate with significant corneal scarring and vascularization was seen.
Bilateral sequential manual small incision cataract surgery as the management of phacomorphic glaucoma in a rare case of Werner's syndrome
Authors: Shakya Rakesh , Ahluwalia Navjot S , Paes Rohil , Parikh Dhairya V , Jain B K
Published: January 2022

We present a case of Werner's syndrome (WS), which is a rare progressive hereditary disorder characterized by accelerated aging. Bilateral cataracts are one of the cardinal signs of WS. The clinical characteristics of our patient met the diagnostic criteria of “Probable WS” according to the International Registry of Werner Syndrome. Our patient presented with bilateral phacomorphic glaucoma. Previous reports involving single case of WS, cataract surgery was performed by clear corneal phacoemulsification. Our patient underwent immediate bilateral sequential manual small incision cataract surgery (IBSCS) with intraocular lens implantation. We highlight the fact that bilateral cataract surgery with Manual small incision cataract surgery (M-SICS) for phacomorphic glaucoma is a safe choice for patients with Werner's syndrome.
Disappearance of choroidal nevi pigmentation following nivolumab treatment
Authors: Chatzicharalampous Kleopas-Gerasimos , Barakos Konstantinos , Papantoniou Dimitrios , Kissopoulou Antheia
Published: January 2022

A 64-year-old caucasian male, with a left eye choroidal nevus, was diagnosed with a nodular cutaneous melanoma of the head, which was radically excised. He experienced a metastatic relapse in the lungs, which was treated for 2 years with nivolumab, an immune checkpoint inhibitor of the programmed cell death 1 (PD-1) receptor. The patient has had annual follow-ups of his choroidal nevus. At the control 2 years follow-up after the start of nivolumab, the nevus unexpectedly disappeared. To our knowledge, this is the second reported case in the literature of choroidal nevus disappearance associated with PD-1 treatment and the first-ever reported case in Sweden.
Orbital cellulitis complicated by central retinal artery occlusion with sparing of cilioretinal artery
Authors: Garg Gaurav , Patidar Narendra , Dahiya Vinit
Published: January 2022

Orbital cellulitis (OC) with an incidence of 0.1 per 100,000 is a sight and life-threatening emergency with a dreadful potential to cause orbital apex syndrome and central retinal artery occlusion (CRAO). In the era of modern antibiotics, visual loss in the case of isolated OC has significantly reduced. But in the event of the added complication of orbital apex syndrome and CRAO, the visual prognosis decreases markedly. A 24-year-old Asian Indian male presented with left eye staphylococcal OC complicated by orbital apex syndrome and CRAO with cilioretinal artery sparing following nasal folliculitis and upper lid preseptal cellulitis. He was promptly treated with culture-sensitive antibiotics, lateral canthotomy, and cantholysis. On follow-up, his vision improved from hand movements to 20/40 with the resolution of inflammation, proptosis, and ophthalmoplegia. To conclude, promptness in diagnosis, treatment, and presence of foveal-sparing CRAO may improve the prognosis of OC.
A case of tuberculous dacryoadenitis with review of literature
Authors: Lahane Sumeet , Munde Sheetal , Chalvadi Ramanna , Prajapati Dhananjay , Parekh Ragini , Lahane Tatyarao
Published: January 2022

Lacrimal gland inflammation is commonly due to viral infection, autoimmune, and idiopathic inflammatory disease. Orbital and adnexal tuberculosis (OTB) is a rare entity even in the TB endemic country of India. TB dacryoadenitis is one of the presentations in the OTB spectrum, with less than 25 cases in the literature. We report the case of a 14-year-old female primarily presented with unilateral dacryoadenitis and cold abscess at the lower lumbar region. Biopsy of lacrimal gland confirmed on histopathology as tuberculosis. Systemic investigation revealed pulmonary and extrapulmonary TB. She was treated with systemic category I anti-tubercular treatment resulting in complete regression of disease.
Late-onset Descemet's membrane detachment secondary to presumed interface fluid syndrome after uneventful deep anterior lamellar keratoplasty for keratoconus
Authors: Galiyugavaradhan Sugaranjini , Pillai Vinay S , Nair Abhilash
Published: January 2022

A forty-year-old male underwent an uneventful big-bubble deep anterior lamellar keratoplasty (DALK) for keratoconus in the right eye. Suture removal was attempted 15 months post-surgery and led to temporal graft host dehiscence that required resuturing of the graft. The patient presented 4 months later with increased intraocular pressure (IOP), graft edema, and nasal Descemet membrane detachment (DMD). IOP control with medication led to reduction and total resolution of DMD and a clear graft. We postulate that the DMD, in this case, was caused by a mechanism similar to the interface fluid syndrome (IFS) that occurs in post-laser in situ keratomileusis (LASIK) eyes and should be considered as a differential diagnosis for DMD following DALK.
Anemic Retinopathy as a Presenting Feature of Severe Dimorphic Nutritional Anemia in a Young Male Patient after Crash Dieting
Authors: Jain Parul , Sanoria Abhilasha
Published: January 2022

We report the case of a 31-year-old male patient who presented for a routine ophthalmological examination. Evaluation revealed the presence of bilateral flame-shaped hemorrhages and Roth's spots. Hematological evaluation revealed the presence of severe iron deficiency anemia with megaloblastic anemia. This case documents the occurrence of anemic retinopathy in dimorphic nutritional anemia after crash dieting (severe calorie restriction).
Comparison of the Conservative Approach with Ureteral Stent Implantation in Treating Hydronephrosis during Pregnancy
Authors: Balıkoğlu Meriç , Bayraktar Burak , Özsoy Çağatay , Kanmaz Ahkam Göksel , Özeren Mehmet
Published: January 2022

Objectives:

Physiological and anatomical changes in the urinary system are expected in pregnancy. Therefore, uretero-hydronephrosis is observed in pregnant women in the second trimester. In this study, it was aimed to investigate the effect of ureteral double J stenting (DBJ) on perinatal outcomes and maternal urinary system values in order to decrease fetal and maternal morbidity of maternal hydronephrosis.

Materials and Methods:

Sixty-three pregnant women included in the study are split into two groups: 44 were administered conservative pain palliation (non-DBJ group/control) and 19 were implanted with a ureteral double J stent (DBJ group/case). Renal functions were evaluated using blood urea nitrogen (BUN) and creatinine levels. The presence of inflammation and infection was investigated using white blood cell (WBC) count, WBC in urine, nitrite presence, and growth in urine culture. The week hydronephrosis began and fetal birth weight and date were scanned.

Results:

There were no statistically significant difference between two groups leucocite, erythrocyte in urine, growth in urine culture, nitrite positivity indicated, and creatinine levels (P > 0.05, for all). BUN values were significantly lower in the DBJ group (P = 0.005). The prevalence of WBC in urine was statistically significantly higher in the DBJ group (P = 0.02). The week of birth was statistically significantly lower in the DBJ group than that in the non-DBJ group (36 ± 2 vs. 37.6 ± 3, P = 0.01).

Conclusion:

Our study suggests that implantation of a DBJ to patients who do not respond to conservative hydronephrosis treatment does not decrease the possibility of preterm birth and low birth weight.
Hemophagocytic Lymphohistiocytosis Trigged by COVID-19 Infection
Authors: Hammami Fatma , Koubaa Makram , Rekik Khaoula , Chaabouni Hana , Chaari Mourad , Smaoui Fatma , Jemaa Mounir Ben
Published: January 2022

The outbreak of the novel coronavirus-19 (COVID-19) rapidly grew into a worldwide pandemic. The link between the disease severity and higher levels of inflammatory markers was reported including cases of hemophagocytic lymphohistiocytosis (HLH), a potentially life-threatening disorder. We report herein a case of HLH trigged by COVID-19 infection and we review all reported cases of HLH secondary to COVID-19 among immunocompromised patients by searching PubMed publications till July 2021. A 69-year-old woman with a previous medical history of diabetes mellitus and rheumatoid arthritis treated with oral steroids presented for a 5-day history of fever, persistent cough, anorexia, and dyspnea. The diagnosis of COVID-19 was confirmed. She received empiric antibiotic therapy, oxygen supply, and corticosteroids. On day 17, laboratory investigations revealed bicytopenia with a platelets rate of 31,000/mm3 and an hemoglobin rate of 8.2 g/dL. Hyperferritinemia, hypertriglyceridemia, and hypofibrinogenemia were noted. Bone marrow aspiration and biopsy revealed images of hemophagocytosis. The HScore yielded 200 points, representing 80%–88% probability of HLH. We continued corticosteroids and treatment. The disease evolution was favorable. The diagnosis of HLH secondary to COVID-19 shoud be considered in front of cytopenia, hyperinflammatory state, and a worsening clinical condition. Prompt diagnosis and treatment improve the prognosis.
Assessment of Neutrophil/Lymphocyte Ratio in Relation to Presentation and Prognosis of Diffuse Large B-Cell Nonhodgkin Lymphoma
Authors: Al-Tameemi Waseem F. , Mahmmood Ahmed Jaber
Published: January 2022

BACKGROUND:

Diffuse large B-cell lymphoma (DLBCL) is representing 30%–40% of all lymphomas. It is an aggressive lymphoma with heterogeneous clinicopathological features. Inflammatory processes have been identified to play an important role in the pathogenesis of lymphoma including the neutrophil-lymphocyte ratio (NL ratio) was associated with a poor prognosis.

AIM OF STUDY:

The aim of this study is to assess neutrophil/lymphocyte (N/L) ratio in relation to clinical presentation, and other prognosticators in DLBCL, and to study the effect of these markers with response rate and early outcome.

PATIENTS AND METHODS:

This is a cohort prospective study with data obtained from May 2018 to November 2019. Data collected from multiple hematological centers in Baghdad, Iraq. A total of 58 adult patients who are newly diagnosed with DLBCL were enrolled. In addition to demographic features, international prognostic index (IPI) score, complete blood parameters (white blood cell count, N/L ratio, had assessed.

RESULTS:

The mean age was 53.54 ± 14.95 years. Twenty-two (45.83%) had extranodal involvement at the presentation. Advanced stage was reported in 34 (70.83%). Median N/L ratio was 3.39 with cut-off values 4.41. There was no significant association with the N/L ratio neither with progression-free survival (PFS) nor with the advanced stage presentation (P = 0.238, 0.343, respectively). It is found also that higher median N/L ratio was significantly associated with high and high-intermediate IPI score (P = 0.03).

CONCLUSION:

The NL ratio has a significant association with the IPI score, but not with the disease PFS.
Autoimmune Hemolytic Anemia in Children
Authors: Paul Vinod , Ittoop Amanta Lucy , Prakash Anand
Published: January 2022

Autoimmune hemolytic anemia is a rare disorder with varied presentations. A primary physician could misdiagnose this condition for other simpler causes of anemia, if not aware of the spectrum of the signs and symptoms of this disease. This may lead to further worsening of the patient, due to delay in starting of the therapy with immunosuppresants. Hasty blood transfusion could cause exacerbation of hemolysis. Both IgG and IgM antibodies could cause this disease, and they are termed as warm and cold antibody hemolytic anemia, respectively. Monitoring and follow-up of patients are also very necessary along with careful tapering of the medications. Evolution of other autoimmune disorders such as systemic lupus erythematosus is also noticed in such children. There is a paucity of literature about this disease, especially from the developing world. In this study, we have shown the clinical profile of 21 children with autoimmune hemolytic anemia, with the treatment given and the response. An attempt to compare our data with the available data from various studies has also been made so that a primary care physician could easily identify the most common symptoms and signs of this disease and treat such children.
Efficacy of Single-Agent Cytarabine in Adult Langerhans Cell Histiocytosis
Authors: Singh Suvir , Singh Jagdeep , Paul Davinder , Jain Kunal
Published: January 2022

Langerhans Cell Histiocytosis (LCH) in adults is rare and has little prospective data to guide therapy. We describe a 36 year old gentleman who presented with a three-month history of isolated cervical lymphadenopathy, from which excision biopsy revealed sheets of large, atypical cells 10-15 um in size, with indented nuclei and fine chromatin along with eosinophilic microabscesses. Immunohistochemistry was positive for CD3, CD20, CD68, CD1a, S100, CD4, Langerin (CD207) and CD45 with a Ki67 index of 10%. PET scan showed FDG-avid uptake in left mastoid air cells, which was confirmed by MRI to indicate bony involvement with disease. Bone marrow and CSF were normal. He was diagnosed as multisystem LCH without risk organ involvement and initiated on single agent cytarabine at 100 mg/m2 five days a month. A PET scan after three cycles showed near complete metabolic resolution. He has completed six cycles of the same and is asymptomatic. He is planned for continuation of Cytarabine for another of 12 to 14 months. Single agent cytarabine appears safe and effective for adult patients with LCH. We provide a short summary of available data: compilation of prospective data will further clarify the utility of this regimen in adult patients with LCH.
Encouraging Inclusive Education for the Blind in Developing Countries
Authors: Adio Adedayo Omobolanle
Published: January 2022

Blindness rates especially avoidable ones still remain high despite various interventions in developing countries. Vision 2020 was therefore unattainable. Once a person goes irreversibly blind, the costs of rehabilitation and educating such a person dramatically rises. The response of government has been to send them to blind schools which has the distinct disadvantage of isolating them from their peers and causes them to lag behind educationally due to teaching methods not commensurate with modern standards. Recently, visually impaired people are encouraged to be schooled alongside their peers in an inclusive manner. For this to be successful, they need to be (re)habilitated first, then empowered with appropriate assistive devices. This communication highlights how this can be done so it can improve the current deplorable statistics of successful blind young people in developing countries such as Nigeria.
Quantitative estimates for the Bakry–Ledoux isoperimetric inequality
Authors: Mai Cong Hung , Ohta Shin-ichi
Published: January 2022

We establish a quantitative isoperimetric inequality for weighted Riemannian manifolds with

\operatorname{Ric}_{\infty} \ge 1

. Precisely, we give an upper bound of the volume of the symmetric difference between a Borel set and a sub-level (or super-level) set of the associated guiding function (arising from the needle decomposition), in terms of the deficit in Bakry–Ledoux’s Gaussian isoperimetric inequality. This is the first quantitative isoperimetric inequality on noncompact spaces besides Euclidean and Gaussian spaces. Our argument makes use of Klartag’s needle decomposition (also called localization), and is inspired by a recent work of Cavalletti, Maggi and Mondino on compact spaces. Besides the quantitative isoperimetry, a reverse Poincaré inequality for the guiding function that we have as a key step, as well as the way we use it, are of independent interest.
Skew-amenability of topological groups
Authors: Juschenko Kate , Schneider Friedrich Martin
Published: January 2022

We study skew-amenable topological groups, i.e., those admitting a left-invariant mean on the space of bounded real-valued functions left-uniformly continuous in the sense of Bourbaki. We prove characterizations of skew-amenability for topological groups of isometries and automorphisms, clarify the connection with extensive amenability of group actions, establish a Følner-type characterization, and discuss closure properties of the class of skew-amenable topological groups. Moreover, we isolate a dynamical sufficient condition for skew-amenability and provide several concrete variations of this criterion in the context of transformation groups. These results are then used to decide skew-amenability for a number of examples of topological groups built from or related to Thompson’s group

F

and Monod’s group of piecewise projective homeomorphisms of the real line.
Longest minimal length partitions
Authors: Bogosel Beniamin , Oudet Édouard
Published: January 2022

This article provides numerical evidence that under volume constraint the ball is the set which maximizes the perimeter of the least-perimeter partition into cells with prescribed areas. We introduce a numerical maximization algorithm which performs multiple optimization steps at each iteration to approximate minimal partitions. Using these partitions we compute perturbations of the domain which increase the minimal perimeter. The initialization of the optimal partitioning algorithm uses capacity-constrained Voronoi diagrams. A new algorithm is proposed to identify such diagrams, by computing the gradients of areas and perimeters for the Voronoi cells with respect to the Voronoi points.
Vanishing theorems for Shimura varieties at unipotent level
Authors: Caraiani Ana , Gulotta Daniel R. , Johansson Christian
Published: January 2022

We show that the compactly supported cohomology of Shimura varieties of Hodge type of infinite

\Gamma_1(p^\infty)

-level (defined with respect to a Borel subgroup) vanishes above the middle degree, under the assumption that the group of the Shimura datum splits at

p

. This generalizes and strengthens the vanishing result proved in [A. Caraiani et al., Compos. Math. 156 (2020)]. As an application of this vanishing theorem, we prove a result on the codimensions of ordinary completed homology for the same groups, analogous to conjectures of Calegari–Emerton for completed (Borel–Moore) homology.
On profinite groups with positive rank gradient
Authors: Nikolov Nikolay
Published: January 2022

We prove that a profinite group

G

with positive rank gradient does not satisfy a group law. In the case when

G

is a pro-

p

group, we show that

G

contains a nonabelian dense free subgroup.
On the core of a low dimensional set-valued mapping
Authors: Shvartsman Pavel
Published: January 2022

Let

\mathfrak{M}=(\mathcal{M},\rho)

be a metric space and let

X

be a Banach space. Let

F

be a set-valued mapping from

\mathcal{M}

into the family

\mathcal{K}_m(X)

of all compact convex subsets of

X

of dimension at most

m

. The main result in our recent joint paper with Charles Fefferman (which is referred to as a “finiteness principle for Lipschitz selections”) provides efficient conditions for the existence of a Lipschitz selection of

F

, i.e., a Lipschitz mapping

f\colon \mathcal{M}\to X

such that

f(x)\in F(x)

for every

x\in\mathcal{M}

.

We give new alternative proofs of this result in two special cases. When

m=2

, we prove it for

X=\mathbb{R}^{2}

, and when

m=1

we prove it for all choices of

X

. Both of these proofs make use of a simple reiteration formula for the “core” of a set-valued mapping

F

, i.e., for a mapping

G\colon \mathcal{M}\to\mathcal{K}_m(X)

which is Lipschitz with respect to the Hausdorff distance, and such that

G(x)\subset F(x)

for all

x\in\mathcal{M}

.
Applications of Eccentric Exercise to Improve Muscle and Mobility Function in Older Adults
Authors: Kim Dae Young , Oh Seung Lyul , Lim Jae-Young
Published: January 2022

Muscle aging ultimately leads to the deterioration of human physiological functioning, including declining muscle strength, loss of muscle mass, and decreased quality of life in advanced age. Eccentric exercise is a key intervention that has the potential to ameliorate this problem. Recent studies have focused on evidence-based exercise interventions to prevent declines in muscle strength and physical function in older adults. This paper reviewed relevant literature on the use of eccentric exercise to improve muscle and mobility function in older adults. We explained not only the changes in mobility that occur with aging but also the rationale for and positive effects of eccentric intervention in older adults. We also explored several proposed mechanisms for the intramuscular changes caused by eccentric muscle contraction and considered the safety and side effects accompanying eccentric training. We concluded by suggesting that eccentric exercise is an exercise modality that can potentially improve muscle strength and enhance mobility in older adults.
Counseling on the Use of Over-the-counter and Limited-Free Medicines for recitation mothers in Cibungur Village, Tasikmalaya, Indonesia
Authors: Sidiq Fahmi
Published: January 2022

Over-the-counter medicines can be purchased without a doctor's prescription and can be purchased at pharmacies and licensed drugstores to treat non-specific minor illnesses. Limited over-the-counter drugs, also known as list W drugs (W: Waarschuwing = warning/alert) are strong drugs that can be purchased without a doctor's prescription, but their use must pay attention to the drug information on the packaging. The results of this counseling are the mothers of recitation in Cibungur village, Parungponteng sub-district, namely knowing about, how to use, get, store and dispose of good and correct medicines. The selection of over-the-counter and over-the-counter drugs is limited. As well as the characteristics of damaged drugs. people are becoming more careful in the use of drugs. Therefore, the University Pharmacy Study Program takes the initiative to provide community service by providing over-the-counter and limited-free drugs and ways to find out damaged drugs.
Education on the use of Social Media as a Marketing Medium for Small Micro and Medium Enterprises (SME) in Cipamokolan Village during the COVID-19 Pandemic
Authors: Saputra Renda Sandi
Published: January 2022

The economy in Indonesia is now growing and developing, especially for SME (small micro and medium enterprises) businesses, in the micro, small and medium movement, many Indonesian people are opening small businesses, by marketing products that are still sought after by buyers, Many Indonesian traders have not used the internet or social media to market their products, even though there are many social media that can be used to market their products, such as Facebook, Instagram, Tiktiok and many more. Currently, social media or the internet can be accessed by anyone from all walks of life. including SME businessmen who use the internet as a means of providing and sharing information about products offered to consumers online. This study discusses how the use of social media by SME in marketing products during the COVID19 pandemic. The purpose of the research is to introduce traders in Cipamokolan village to be able to better utilize social media as a marketing tool in order to have a bigger market potential. This research method is a qualitative method using a descriptive approach by utilizing secondary data from various literatures such as books, journals/articles and homepages to access the latest data and information related to the impact of COVID-19 and the use of social media for the recovery of SME. The result of the research is that social media is an effective means of communication, can increase market share and help business decisions. The community in Cipamokolan village can increase sales volume by more than 100% if the information is updated every day and consistently.
Preliminary Study of Common House Gecko (Cosymbotus platyurus) Density in Java Island
Authors: Suwatik Suwatik , Wahyuni Nenden Sri , Mulyawati Santi , Rohmah Mulik Siti Nur , Dewi Anggraeni Rr. Indira , Gerungan Raflen Ari , Diki Diki
Published: January 2022

Common house gecko (Cosymbotus platyurus) is the most abundant house gecko species in Indonesia. The geckos live in home yard, garden, and in homes. It is part of food chain in its habitat, as its preys include cockroaches, flies, and termites. Previous studies found that this gecko are not found in mountainous area in West Java. In this study, the researchers observe population density of common house geckos in various types of habitats (houses and parks) with their home territory. The methods used were direct survey methods followed by literature study. The study is conducted in Java island (Jakarta, Tangerang, Bandung, Bogor, Sleman). Preliminary result of this study is house geckos are very active at night, because of the effect of light produced by lights that attract the attention of insects, gecko food.
COVID-19 Pandemisinde Ertelenen Cerrahi Girişimlerin Hasta Sonuçlarına Etkisinin İncelenmesi
Authors: TÜTÜNCÜ Şerife Gözde , YILMAZ DÜNDAR Gönül
Published: January 2022

Koronavirüs Hastalığı-2019 (COVID-19) salgını, sağlık bakım hizmetlerini dünya genelinde etkilemiştir. Salgın nedeniyle sağlık hizmetlerinin temel amacı kritik hasta bakım gereksinimlerinin giderilmesi olmuştur. Bu nedenle pandeminin başladığı Mart 2020’den itibaren ülkemizde ve dünyada vaka sayısı azalmaya başlayana kadar elektif cerrahi girişimlere ara verilmiştir. COVID-19 salgını sırasında iptal edilen ya da ertelenen elektif cerrahi girişimlerin çoğunluğunun, kanser, iyi huylu tümör ve sezaryen ameliyatları olduğu bilinmektedir. Bu nedenle cerrahi girişimler hastalığın önceliğine ve elektif olma durumuna göre ertelenmelidir. Salgın nedeniyle gecikmiş cerrahi girişimler özellikle kanser hastalarında komplikasyonların artmasına, nüks ve sağkalım açısından klinik olarak anlamlı farklılıklara ve sonuçlara neden olmaktadır. Ayrıca infeksiyon bulaş riskinden korkan hastaların hastalık süreci takibinde de aksaklıklar görülmüştür. Bu süreçte hasta takiplerinin istenilen düzeyde yapılabilmesi ve yüz yüze hasta takibinin kısıtlanması için tele-sağlık uygulamaları kullanılmaya başlanmıştır. Sağlık verilerinin kolaylıkla takip edildiği tele-sağlık uygulamaları kapsamında hastaların yaşamsal bulguları, kan glikoz ve ağrı düzeyi, ilaç uyumu, günlük yaşam aktiviteleri gibi birçok parametre takip edilebilir. Tele- sağlık uygulamaları ile hastanın durumunda görülen değişiklikler erken dönemde belirlenerek gerekli görüldüğünde uygun sağlık kurumlarına yönlendirilmesi sağlanabilir. Ayrıca hastaların tedavi süreci ve bakıma yönelik soruları kısa sürede yanıtlanarak memnuniyet düzeyleri de arttırabilir.
Multi-objective selection of portfolios using ESG controversies
Authors: Oliver Javier
Published: January 2022

It is increasingly common for investors to demand a certain degree of compliance and commitment to environmental, social and governance (ESG) variables in their investments, without renouncing to maximising returns with the minimum possible risk. In this paper, a multi-objective optimisation model applied to Dow Jones stocks is used to analyse the construction of portfolios taking into account the level of controversies of each asset in the portfolio. Controversies are associated with non-compliance by companies in ESG areas, either due to a lack of dedication of resources or a lack of control. The a priori expected positive relationship between higher profitability and low number of controversies is not confirmed. This means that those companies with the highest returns are not necessarily those with the less controversies and vice versa. This finding contradicts the results obtained by some previous studies and underline the importance of applying multi-objective models to properly account for investors’ preferences, including ESG compliance.
Placing Health
Authors: Blackman Tim
Published: January 2022

Involving citizens in policy decision-making has been a central goal of the Labour government since it came to power. But what happens when the public are drawn into debate with unfamiliar others in the unknown world of policy making at national level? This book sets out to understand the contribution that citizens can realistically make.
Медичне забезпечення Збройних Сил України у контексті трансформації суспільної охорони здоров’я: нормативно-правові аспекти
Authors: Zhakhovsky V. O. , Livinskyi V. G , Ostaschenko T. M. , Ivanko O. M. , Vasiuk N. O.
Published: January 2022

Мета роботи – аналіз законодавчої і нормативно-правової бази суспільної охорони здоров’я України та дослідження її впливу на медичне забезпечення Збройних Сил (ЗС) України.

Матеріали та методи. Використано законодавчі та нормативно-правові акти з питань охорони здоров’я в Україні, публікації у відкритих наукових джерелах. Методи дослідження: бібліографічний, аналітичний, системного підходу.

Результати. Встановлено, що стан охорони здоров’я в Україні потребує радикальних змін, зокрема в частині удосконалення законодавчого врегулювання забезпечення населення своєчасною та якісною медичною допомогою. З цією метою Президентом України поставлене завдання Кабінету Міністрів України розробити та затвердити Стратегічний план розвитку системи охорони здоров’я населення України на період до 2030 року з визначенням чітких механізмів, строків і відповідальних за виконання забезпечення рівного доступу громадян України до своєчасної, безпечної та якісної екстреної, первинної, вторинної (спеціалізованої), третинної (високоспеціалізованої), паліативної медичної допомоги та реабілітації у сфері охорони здоров’я.

Висновки. Виконання завдань, визначених Стратегічним оборонним бюлетенем України та Стратегією розвитку Медичних Сил Збройних Сил України до 2035 року передбачає поетапне нарощування спроможностей Медичних сил ЗС України для виконання завдань з медичного забезпечення ЗС України як у мирний час так і в особливий період, що корелює з перспективами розвитку системи охорони здоров’я в Україні та Стратегією людського розвитку України, рішенням Ради національної безпеки і оборони України «Про стан національної системи охорони здоров’я та невідкладні заходи щодо забезпечення громадян України медичною допомогою».
Coordination aspects of pharmacovigilance system adjustment in terms of the global COVID-19 pandemic
Authors: Ostaschenko Т. М. , Kozak N. D. , Kozak D. О.
Published: January 2022

The purpose is to overview the crucial pharmacovigilance system adjustment measures concerning COVID-19 widespread pandemic and enlightens main current aspects of pharmacovigilance system revamp.

Materials and methods. There were used common science theoretical methods (system analysis, generalization and systems approach); bibliographic method (elaboration of scientific related literature on topic).

Results. Revamping pharmacovigilance system requires being improved in regulatory capacities, the use of appropriate public-health-driven science-based and user-friendly technologies, including digital technologies, and innovations to expand access to quality medical and relevant information. These proposals can promote health by putting pharmacovigilance at the center of efforts to achieve a sustainable healthcare system that uses universal health coverage and the health-related Sustainable Development Goals.

Conclusion. Vaccine safety is very important for the success of any vaccination program. A robust vigilance system will help detect, report and prevent any adverse reactions associated with vaccination. Effective pharmacovigilance of the COVID-19 vaccine, when ready for use, will prevent any adverse events associated with the vaccine and dispel any unreasonable concerns among vaccine users.
Історичні аспекти формування та розвитку системи медичного забезпечення Збройних Сил України
Authors: Ostashchenko Т. М. , Zhakhovskyi V. O. , Livinskyi V. G. , Shvets A. V.
Published: January 2022

Мета роботи. Дослідження створення і становлення медичної служби Збройних Сил (ЗС) України та етапів формування і розвитку системи медичного забезпечення ЗС України.

Матеріали та методи. Використано законодавчі та нормативно-правові акти, доктринальні і керівні документи, монографії та інформаційно-довідкові матеріали щодо формування і розвитку військової охорони здоров’я та медичного забезпечення ЗС України. Методи дослідження: історичний, бібліографічний, аналітичний, системного підходу, узагальнення.

Результати. Наведено основні етапи формування та розвитку ЗС України відповідно до загальнодержавних програмних документів. Висвітлено створення і становлення медичної служби ЗС України та етапи формування і розвитку системи медичного забезпечення ЗС України у контексті будівництва та розвитку ЗС України. Розкрито та проаналізовано зміст основних заходів кожного етапу реформування і розвитку системи медичного забезпечення ЗС України, показано досягнення та акцентовано увагу на проблемах і недоліках, що мали місце під час їх проведення.

Висновки. Формування та розвиток ЗС України здійснювалися згідно законодавчих і нормативно-правових актів України. Розвиток системи медичного забезпечення ЗС України відбувався відповідно до етапів будівництва та розвитку ЗС України. Подальший розвиток системи медичного забезпечення ЗС України та нарощування спроможностей Медичних сил здійснюватиметься відповідно до нового Стратегічного оборонного бюлетеня України, що затверджений Указом Президента України від 17 вересня 2021 року № 473, та інших програмних документів щодо розвитку сил оборони.