bluuebunny/crossref_metadata_2025 huggingface dataset:
DAGmap: Multi-Drone SLAM via a DAG-Based Distributed Ledger
Authors: Park Seongjoon , Kim Hwangnam
Published: January 2022

Simultaneous localization and mapping (SLAM) in unmanned vehicles, such as drones, has great usability potential in versatile applications. When operating SLAM in multi-drone scenarios, collecting and sharing the map data and deriving converged maps are major issues (regarded as the bottleneck of the system). This paper presents a novel approach that utilizes the concepts of distributed ledger technology (DLT) for enabling the online map convergence of multiple drones without a centralized station. As DLT allows each agent to secure a collective database of valid transactions, DLT-powered SLAM can let each drone secure global 3D map data and utilize these data for navigation. However, block-based DLT—a so called blockchain—may not fit well to the multi-drone SLAM due to the restricted data structure, discrete consensus, and high power consumption. Thus, we designed a multi-drone SLAM system that constructs a DAG-based map database and sifts the noisy 3D points based on the DLT philosophy, named DAGmap. Considering the differences between currency transactions and data constructions, we designed a new strategy for data organization, validation, and a consensus framework under the philosophy of DAG-based DLT. We carried out a numerical analysis of the proposed system with an off-the-shelf camera and drones.
Analysis of Three-Dimensional Rigid-Body Impact with Friction
Authors: Sun Han , Baruh Haim
Published: January 2022

This paper is concerned with the modeling and simulation of two- and three-dimensional impact in the presence of friction. Single impacts are considered, and the impact equations are solved algebraically. Impact generates impulsive normal and frictional forces and the direction of sliding can change during impact. A procedure is developed to estimate the change in direction of sliding during three-dimensional impact. The modes of impact, such as sliding, sticking, or change in direction of sliding, are classified for both two- and three-dimensional impact. Simulations are conducted to analyze the energy lost, change in impact direction, and stick-slip conditions, where different models for restitution are compared. A closed-form solution is developed to analyze the modes of sliding for two-dimensional impact.
Understanding School Success of Migrant Students: An International Perspective
Authors: Makarova Elena , Kassis Wassilis
Published: January 2022

Despite existing educational inequalities, the literature provides hardly any empirically validated insights into the school success pathways of migrants [...]
Improvement of the Performance of Models for Predicting Coronary Artery Disease Based on XGBoost Algorithm and Feature Processing Technology
Authors: Zhang Shasha , Yuan Yuyu , Yao Zhonghua , Wang Xinyan , Lei Zhen
Published: January 2022

Coronary artery disease (CAD) is one of the diseases with the highest morbidity and mortality in the world. In 2019, the number of deaths caused by CAD reached 9.14 million. The detection and treatment of CAD in the early stage is crucial to save lives and improve prognosis. Therefore, the purpose of this research is to develop a machine-learning system that can be used to help diagnose CAD accurately in the early stage. In this paper, two classical ensemble learning algorithms, namely, XGBoost algorithm and Random Forest algorithm, were used as the classification model. In order to improve the classification accuracy and performance of the model, we applied four feature processing techniques to process features respectively. In addition, synthetic minority oversampling technology (SMOTE) and adaptive synthetic (ADASYN) were used to balance the dataset, which included 71.29% CAD samples and 28.71% normal samples. The four feature processing technologies improved the performance of the classification models in terms of classification accuracy, precision, recall, F1 score and specificity. In particular, the XGBboost algorithm achieved the best prediction performance results on the dataset processed by feature construction and the SMOTE method. The best classification accuracy, recall, specificity, precision, F1 score and AUC were 94.7%, 96.1%, 93.2%, 93.4%, 94.6% and 98.0%, respectively. The experimental results prove that the proposed method can accurately and reliably identify CAD patients from suspicious patients in the early stage and can be used by medical staff for auxiliary diagnosis.
A Review on Solution-Processed Organic Phototransistors and Their Recent Developments
Authors: Tavasli Aybuke , Gurunlu Betul , Gunturkun Dilara , Isci Recep , Faraji Sheida
Published: January 2022

Today, more disciplines are intercepting each other, giving rise to “cross-disciplinary” research. Technological advancements in material science and device structure and production have paved the way towards development of new classes of multi-purpose sensory devices. Organic phototransistors (OPTs) are photo-activated sensors based on organic field-effect transistors that convert incident light signals into electrical signals. The organic semiconductor (OSC) layer and three-electrode structure of an OPT offer great advantages for light detection compared to conventional photodetectors and photodiodes, due to their signal amplification and noise reduction characteristics. Solution processing of the active layer enables mass production of OPT devices at significantly reduced cost. The chemical structure of OSCs can be modified accordingly to fulfil detection at various wavelengths for different purposes. Organic phototransistors have attracted substantial interest in a variety of fields, namely biomedical, medical diagnostics, healthcare, energy, security, and environmental monitoring. Lightweight and mechanically flexible and wearable OPTs are suitable alternatives not only at clinical levels but also for point-of-care and home-assisted usage. In this review, we aim to explain different types, working mechanism and figures of merit of organic phototransistors and highlight the recent advances from the literature on development and implementation of OPTs for a broad range of research and real-life applications.
Distributed Hierarchical Control for Islanded Microgrids Based on Adjustable Power Consensus
Authors: Wan Xiaofeng , Wu Jingwan
Published: January 2022

For the problem of power allocation in microgrid hierarchical control, a distributed hierarchical control strategy based on consensus algorithm is proposed. When the load suddenly increases, due to the different adjustable power of different distributed generators (DGs), overcharging and discharging of DGs will result if the increased load is not redistributed. The distributed hierarchical control strategy proposed in this paper defines the proportion between the local increased load and the local adjustable power as the response ratio. With the objective of ensuring that the frequency and voltage of the microgrid can be restored to their rated value, the response ratios of DGs are adjusted by applying the consensus algorithm. Further, the microgrid realizes the reasonable operation of the microgrid by dynamically distributing the increased load in real time. Finally, the feasibility and effectiveness of the proposed strategy is verified by analyzing the stability of the system and building a microgrid simulation model in the Matlab/Simulink simulation platform.
Model Predictive Control Scheme of a Four-Level Quasi-Nested Converter Fed AC-Drive, with dc-Link Voltage-Drift Compensation
Authors: Reusser Carlos A. , Herrera Ramón
Published: January 2022

In this paper, a Model Predictive Control (MPC) strategy is introduced for its application in a four-level quasi-nested topology, feeding an Interior Permanent Magnet Synchronous Machine (IPMSM) AC-drive. The proposed control strategy is capable to synthesize the required output space vectors to ensure perfect tracking of the AC-drive speed reference under different loading conditions, while also ensuring voltage balance between the dc-link capacitors. The proposed converter topology is based on a reduced number of components compared to other mature converter topologies, such as the neutral-point clamped converter (NPC) or the active neutral-point clamped converter (ANPC) topologies, when compared in terms of the number of output voltage levels, since this quasi-nested topology does not require passive clamping devices such as diodes or active switches. Moreover, no floating dc-link capacitors with asymmetrical voltage levels are employed, thus simplifying the dc-link capacitor voltage balance mechanism. This work presents the switching operation principles and MPC control law when supplying an IPMSM AC-drive load are addressed in detail. Simulation and validation results using a Hardware in the Loop (HIL) prototype under different operation conditions are presented in order to validate the proposed converter topology and control strategy.
Role of Happiness When Evaluating Society
Authors: Grinde Bjørn
Published: January 2022

Happiness, or life satisfaction, has become an important factor when considering what should be the objective of a society. Understanding the nature of happiness is thus important. The text offers a biological—specifically evolutionary—framework, which suggests that happiness can be described as the net impact of positive and negative feelings. It follows that a key issue is to explain what these feelings are about. The present situation and options for improving the score of happiness are discussed.
Genome-Wide Comprehensive Analysis of PtLACs: Prediction and Verification of the Functional Divergence of Tandem-Duplicated Genes
Authors: Xu Nan , Han Xue-Min , Xue Yuan , Zhuge Xiang-Lin , Guan Chao-Nan , Yang Hai-Ling
Published: January 2022

Laccases (EC 1.10.3.2) have been widely considered to participate in the metabolic processes of lignin synthesis, osmotic stress response, and flavonoid oxidation in higher plants. The research into Populus trichocarpa laccase focused on the synthesis of lignin in the past few years. In this study, for the first time, a comprehensive analysis of 53 laccase copies in the P. trichocarpa genome was conducted. Positive selection analysis using the branch-site model indicated that LAC genes in terrestrial plants have undergone selective pressure for adaptive evolution. On the basis of the phylogenetic relationship, we reconstructed the evolutionary process of terrestrial plant laccase and found that this gene family began to expand during the evolution of angiosperms. Tandem duplication is the main form of expansion of the PtLAC gene family. The analysis of the sequence characteristics, gene structure, expression pattern, and gene synonymous mutation rate of PtLACs provided a theoretical basis for the functional divergence of tandem duplicated genes. The synonymous mutation rate was used to quantify the divergence time of 11 tandem duplicated gene clusters. Cluster 2, with the earliest divergence time and lower share of sequence similarity, and cluster 5, with the latest divergence time and higher share of similarity, were selected in this study to explore the functional divergence of tandem-duplicated gene clusters. Tobacco subcellular localization and Arabidopsis transgenes verified the functional differentiation of PtLAC genes in cluster 2 and the functional non-differentiation of PtLAC genes in cluster 5. The results of this study provide a reference for the functional differentiation of tandem-duplicated PtLAC.
Modelling and Analysis of Performance Characteristics in a 60 Ghz 802.11ad Wireless Mesh Backhaul Network for an Urban 5G Deployment
Authors: Mackay Michael , Raschella Alessandro , Toma Ogeen
Published: January 2022

With the widespread deployment of 5G gaining pace, there is increasing interest in deploying this technology beyond traditional Mobile Network Operators (MNO) into private and community scenarios. These deployments leverage the flexibility of 5G itself to support private networks that sit alongside or even on top of existing public 5G. By utilizing a range of virtualisation and slicing techniques in the 5G Core (5GC) and heterogeneous Radio Access Networks (RAN) at the edge, a wide variety of use cases can be supported by 5G. However, these non-typical deployments may experience different performance characteristics as they adapt to their specific scenario. In this paper we present the results of our work to model and predict the performance of millimeter wave (mmWave) backhaul links that were deployed as part of the Liverpool 5G network. Based on the properties of the 802.11ad protocol and the physical characteristics of the environment, we simulate how each link will perform with different signal-to-noise ratio (SNR) and Packet Error Rate (PER) values and verify them against real-world deployed links. Our results show good convergence between simulated and real results and provide a solid foundation for further network planning and optimization.
Numerical Investigation of the Influence of Tire Deformation and Vehicle Ride Height on the Aerodynamics of Passenger Cars
Authors: Semeraro Francesco Fabio , Schito Paolo
Published: January 2022

Wheels and wheel houses contribute up to 25% of the total aerodynamic drag of passenger cars and interact in a complex way with their surroundings. Rims and tires induce complex flow separation mechanisms in a highly unsteady regime and the proximity to the ground enhances these phenomena. To have a clearer understanding of the flow mechanisms that develop around wheels and inside wheel houses, the effect of tire deformation and vehicle ride height on the aerodynamics of passenger cars has been investigated with unsteady CFD simulations. Tire deformation is modelled with an empirical formulation that provides close-to-real deformed shapes, while vehicle ride height changes are made by applying vertical translations the vehicle body. Slick tire geometries and closed rims have been analysed and their rotation has been modelled with a tangential velocity component applied to their surface. The investigation has been conducted in three steps: different car heights and tire deformation levels have been investigated separately and then combined, classifying the results on the basis of the drag of the vehicle. Results show that even small tire deformation levels can significantly affect the aerodynamic drag, thus deformation should be included in simulations and treated with caution.
Study of Stability, Cytotoxic and Antimicrobial Activity of Chios Mastic Gum Fractions (Neutral, Acidic) after Encapsulation in Liposomes
Authors: Gortzi Olga , Rovoli Magdalini , Katsoulis Konstantinos , Graikou Konstantia , Karagkini Despoina-Aikaterini , Stagos Dimitrios , Kouretas Dimitrios , Tsaknis John , Chinou Ioanna
Published: January 2022

Mastic gum is a resinous sap produced by Pistacia lentiscus growing in the island of Chios (Greece) and has been recognized since Antiquity for its distinctive aroma as well as medical properties (antimicrobial, antioxidant, anti-inflammatory ones). The oral absorption of Chios Mastic gum (an insoluble polymer of poly-β-myrcene is among the most abundant contents) is poor due to its low water-solubility. We report in this study, two different Chios mastic gum extracts, the acidic mastic gum extract—AMGE—and the neutral one—NMGE, both prepared after removal of the contained polymer in order to ameliorate solubility and enhance in vivo activity. Liposomes are presented as a promising delivery system due to their physicochemical and biophysical properties to increase stability and absorption efficiency of the mastic gum extracts within the gastrointestinal (GI) tract. The aim of this study was to evaluate the stability in GI simulated conditions together with cytotoxic and antimicrobial activity of the two extracts (AMGE and NMGE) after encapsulation in a well characterized liposome formulation. Liposomes-AMGE complex showed an improved stability behavior in GI simulated conditions. Both assayed extracts showed significant dose dependent inhibition against the growth of liver cancer HepG2 cells and an interesting antimicrobial activity against several microorganisms. Conclusively, encapsulation could be evaluated as a beneficial procedure for further applications of mastic resin.
Aged Pericarpium Citri Reticulatae ‘Chachi’ Attenuates Oxidative Damage Induced by tert-Butyl Hydroperoxide (t-BHP) in HepG2 Cells
Authors: Yu Qian , Tao Yexing , Huang Yuting , Zogona Daniel , Wu Ting , Liu Ruiting , Pan Siyi , Xu Xiaoyun
Published: January 2022

This study investigated the protective effects of aged Pericarpium Citri Reticulatae ‘Chachi’ (PCR-C) on tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in HepG2 cells. According to HPLC analysis, PCR-C aged 10 years (PCR-C10) had the highest flavonoids content, especially polymethoxyflavones (PMFs), compared with the fresh peel of Citrus reticulata cv. ‘Chachiensis’ and PCR-C aged 1, 3, and 5 years. Then, flavonoids-rich PCR-C samples and non-flavonoids-rich PCR-C samples (NF) were prepared by extracting and purifying PCR-C of different aging periods, for further cell experiments. Pretreatment with flavonoids-rich PCR-C samples (particularly PCR-C10) considerably reversed t-BHP-induced oxidative damage in HepG2 cells by improving cell viability, increasing SOD activity and GSH levels and reducing the overproduction of ROS and MDA. Correlation analysis further indicated that the accumulation of PMFs, mainly 5,6,7,4′-tetramethoxyflavone and nobiletin, was the main reason that PCR-C10 maintained the redox balance in HepG2 cells. These findings provided direct evidence for the cellular antioxidant activity of aged PCR-C and a guide for PCR-C’s classification, authentication and rational use.
Arsenic in Portuguese Rice: Is There Any Risk?
Authors: Silva Alexandra , Pereira André , Silva Liliana , Pena Angelina
Published: January 2022

Arsenic is a metalloid with natural and anthropogenic sources and its inorganic form is toxic to humans. Rice is highly consumed worldwide and is prone to arsenic contamination; therefore, this study evaluated the inorganic arsenic content of 70 Portuguese rice samples. These were analysed through inductively coupled plasma mass spectrometry (ICP-MS) with a detection limit of 3.3 µg kg−1. The average contamination was of 29.3 µg kg−1, with brown and short rice presenting higher values than white and long rice. The highest concentration, 100 µg kg−1, equalled the maximum residue limit (MRL) for rice destined for infants’ consumption. The estimated daily intake (EDI) surpassed the benchmark dose (lower confidence limit 10%) (BMDL10) of 0.3 µg kg−1 of bw/day considering children in the 95th percentile of rice consumption and the worst-case scenario concentration. However, other sources also contribute to the EDI and some population groups can exceed the BMDL10.
Performance Testing of Bacillus cereus Chromogenic Agar Media for Improved Detection in Milk and Other Food Samples
Authors: Fuchs Eva , Raab Christina , Brugger Katharina , Ehling-Schulz Monika , Wagner Martin , Stessl Beatrix
Published: January 2022

In this study, the performance of four alternative selective chromogenic B. cereus agar was compared to the reference mannitol-yolk polymyxin (MYP) agar (ISO 7932) using inclusion and exclusion test strains (n = 110) and by analyzing naturally contaminated milk and other food samples (n = 64). Subsequently, the panC group affiliation and toxin gene profile of Bacillus cereus senso lato (s.l.) isolates were determined. Our results corroborate that the overall best performing media CHROMagar™ B. cereus (93.6% inclusivity; 82.7% exclusivity) and BACARA® (98.2% inclusivity, 62.7% exclusivity) are more sensitive and specific compared to Brilliance™ B. cereus, MYP and ChromoSelect Bacillus Agar. Both media allow unequivocal detection of B. cereus with low risks of misidentification. Media containing ß-D-glucosidase for the detection of presumptive B. cereus may form atypical colony morphologies resulting in a false negative evaluation of the sample. Naturally contaminated samples presented high numbers of background flora, while numbers of presumptive B. cereus were below the detection limit (<10 CFU g−1 or mL−1). Recovery after freezing resulted in the highest detection of B. cereus s.l. on BACARA® (57.8%), CHROMagar™ B. cereus (56.3%) and MYP agar (54.7%). The panC/toxin profile combination IV/A was the most abundant (33.0%), followed by III/F (21.7%) and VI/C (10.4%). More panC and toxin combinations were present in 15.6% of samples when reanalyzed after freezing. In order to improve detection and confirmation of B. cereus s.l. in food samples, we recommend the parallel use of two complementary selective media followed by molecular characterization (e.g., panC typing combined with toxin gene profiling). When determining psychrotolerant or thermophilic members of the B. cereus group, the selective agar media should additionally be incubated at appropriate temperatures (5 °C, ≥45 °C). If high-risk toxin genes (e.g., ces or cytK-1) are detected, the strain-specific ability to produce toxin should be examined to decisively assess risk.
On the Semi-Local Convergence of a Fifth-Order Convergent Method for Solving Equations
Authors: Argyros Christopher I. , Argyros Ioannis K. , Shakhno Stepan , Yarmola Halyna
Published: January 2022

We study the semi-local convergence of a three-step Newton-type method for solving nonlinear equations under the classical Lipschitz conditions for first-order derivatives. To develop a convergence analysis, we use the approach of restricted convergence regions in combination with majorizing scalar sequences and our technique of recurrent functions. Finally, a numerical example is given.
Existence and Uniqueness of Solutions to a Nabla Fractional Difference Equation with Dual Nonlocal Boundary Conditions
Authors: Gopal Nandhihalli Srinivas , Jonnalagadda Jagan Mohan
Published: January 2022

In this paper, we look at the two-point boundary value problem for a finite nabla fractional difference equation with dual non-local boundary conditions. First, we derive the associated Green’s function and some of its properties. Using the Guo–Krasnoselkii fixed point theorem on a suitable cone and under appropriate conditions on the non-linear part of the difference equation, we establish sufficient requirements for at least one and at least two positive solutions of the boundary value problem. Next, we discuss the existence and uniqueness of solutions to the considered problem. For this purpose, we use Brouwer and Banach fixed point theorem, respectively. Finally, we provide a few examples to illustrate the applicability of established results.
A Geoscientific Review on CO and CO2 Ices in the Outer Solar System
Authors: Ahrens Caitlin , Meraviglia Hypatia , Bennett Christopher
Published: January 2022

Ground-based telescopes and space exploration have provided outstanding observations of the complexity of icy planetary surfaces. This work presents our review of the varying nature of carbon dioxide (CO2) and carbon monoxide (CO) ices from the cold traps on the Moon to Pluto in the Kuiper Belt. This review is organized into five parts. First, we review the mineral physics (e.g., rheology) relevant to these environments. Next, we review the radiation-induced chemical processes and the current interpretation of spectral signatures. The third section discusses the nature and distribution of CO2 in the giant planetary systems of Jupiter and Saturn, which are much better understood than the satellites of Uranus and Neptune, discussed in the subsequent section. The final sections focus on Pluto in comparison to Triton, having mainly CO, and a brief overview of cometary materials. We find that CO2 ices exist on many of these icy bodies by way of magnetospheric influence, while intermixing into solid ices with CH4 (methane) and N2 (nitrogen) out to Triton and Pluto. Such radiative mechanisms or intermixing can provide a wide diversity of icy surfaces, though we conclude where further experimental research of these ices is still needed.
Adverse Perinatal Outcomes in COVID-19 Infected Pregnant Women: A Systematic Review and Meta-Analysis
Authors: Pathirathna Malshani L. , Samarasekara Buddhini P. P. , Dasanayake Thakshila S. , Saravanakumar Padmapriya , Weerasekara Ishanka
Published: January 2022

The impact of COVID-19 virus infection during pregnancy is still unclear. This systematic review and meta-analysis aimed to quantitatively pool the evidence on impact of COVID-19 infection on perinatal outcomes. Databases of Medline, Embase, and Cochrane library were searched using the keywords related to COVID-19 and perinatal outcomes from December 2019 to 30 June 2021. Observational studies comparing the perinatal outcomes of COVID-19 infection in pregnancy with a non-infected comparator were included. The screening process and quality assessment of the included studies were performed independently by two reviewers. Meta-analyses were used to pool the comparative dichotomous data on perinatal outcomes. The database search yielded 4049 results, 1254 of which were duplicates. We included a total of 21 observational studies that assessed the adverse perinatal outcomes with COVID-19 infection. The odds of maternal death (pooled OR: 7.05 [2.41−20.65]), preeclampsia (pooled OR: 1.39 [1.29−1.50]), cesarean delivery (pooled OR: 1.67 [1.29−2.15]), fetal distress (pooled OR: 1.66 [1.35−2.05]), preterm birth (pooled OR: 1.86 [1.34−2.58]), low birth weight (pooled OR: 1.69 [1.35−2.11]), stillbirth (pooled OR: 1.46 [1.16−1.85]), 5th minute Apgar score of less than 7 (pooled OR: 1.44 [1.11−1.86]) and admissions to neonatal intensive care unit (pooled OR: 2.12 [1.36−3.32]) were higher among COVID-19 infected pregnant women compared to non-infected pregnant women.
Intrasession Reliability Analysis for Oscillometric Blood Pressure Method Using a Digital Blood Pressure Monitor in Peruvian Population
Authors: Barrios-Fernandez Sabina , Sosa-Sánchez Eduardo Manuel , Carlos-Vivas Jorge , Muñoz-Bermejo Laura , Morenas-Martín Jesús , Apolo-Arenas María Dolores , Adsuar Jose Carmelo , Domínguez-Muñoz Francisco Javier
Published: January 2022

Blood Pressure (BP) is one of the most used measured clinical parameters in health promotion and intervention. BP measures can vary due to different parameters, so we aim to study the intrasession test–retest reliability for an oscillometric method using a digital tensiometer in the Peruvian population aged over 15 with and without a diagnosis of hypertension (HT). Data were taken from the Demographic and Family Health Survey conducted in Peru in 2019. Technicians had to follow a standardized protocol on the conditions to carry out a valid and reliable measurement. Relative reliability was excellent in most cases (intraclass correlation coefficient > 0.9); absolute reliability was excellent (standard error of measurement < 5%) and smallest real difference < 10% in most cases. The Bland–Altman plot showed a systematic error of 2.36 for systolic BP in men and 2.16 in women, and 0.823 for diastolic BP in men and 0.71 for diastolic BP in women. Results suggest that the oscillometric method with a digital blood pressure monitor was reliable in absolute and relative terms in this population, so it could be used as a reliable control test to measure changes after an intervention.
Classical Thermodynamic Analysis of Deuterium-Based Fusion Reactions
Authors: Tosti Silvano , Marrelli Luigi
Published: January 2022

The fusion reactions involving deuterium are of great interest for the exploitation of the fusion energy via magnetic-confinement devices. In classical thermodynamics, the spontaneity of a process is established through the assessment of the change in Gibbs free energy. So far, the feasibility of nuclear reactions has been characterized in terms of cross section and Q-value while the entropic term (T ΔS) has been neglected. Such an assumption is always justified for fission reactions where the term ΔS is positive. In the case of fusion reactions that operate at very high temperatures (106–107 K) and where ΔS is negative, the change in Gibbs free energy may be positive, making the reaction non-spontaneous. This paper proposes a classical thermodynamic analysis of D-based reactions of interest for the magnetic-confinement fusion applications. The entropy contribution was evaluated via the Sackur–Tetrode equation while the change in enthalpy was considered constant and as corresponding to the Q-value of the fusion reaction. The results of the thermodynamic analysis are compared with nuclear reaction feasibility criteria based on the reaction reactivity. The DT and D3He reactions show a high degree of spontaneity although the second one presents a lower reactivity. An increase in temperature could enhance the reactivity of the D3He reaction at the cost of decreasing its thermodynamic spontaneity. Both branches of the DD reaction are characterized by a much lower thermodynamic spontaneity than that of the DT and D3He reactions. Furthermore, at the temperature of their maximum cross section, the DD reactions exhibit a largely positive change in Gibbs free energy and, therefore, are not spontaneous. At the temperature of magnetic-confinement fusion machines (1.5 × 108 K), among the D-based reactions studied, the DT one exhibits the highest degrees of spontaneity and reactivity.
Lack of Awareness of IT Adoption and Use Theories by IT/IS Project Managers: Poor Relevance, Unfocused Research or Deficient Education?
Authors: Varajão João , Carvalho João Álvaro , Silva Tiago , Pereira Jaime
Published: January 2022

Adoption, use, and diffusion of Information Technology (IT) applications, together with their widespread success, are among the most popular topics in Information Systems (IS) research. However, the impact of the acquired understanding of those phenomena on IS practice is not discernible. In fact, IT adoption, use, and diffusion are subjects scarcely mentioned in what concerns the practices of IT/IS professionals. This article addresses the question of IT/IS practitioners’ awareness of models and theories regarding the adoption, use, and diffusion of IT applications and their success. It describes two surveys of IT/IS project managers that look into their knowledge on a selected set of models/theories widely addressed in IS research. The results show that these project managers are not aware of IT adoption, use, and diffusion models/theories. The article ends with a discussion that attempts to find justifications for that evidence and stresses out the need for further research focused on translating the extant theoretical models into actionable knowledge.
A Systematic Review of Applications of Machine Learning Techniques for Wildfire Management Decision Support
Authors: Bot Karol , Borges José G.
Published: January 2022

Wildfires threaten and kill people, destroy urban and rural property, degrade air quality, ravage forest ecosystems, and contribute to global warming. Wildfire management decision support models are thus important for avoiding or mitigating the effects of these events. In this context, this paper aims at providing a review of recent applications of machine learning methods for wildfire management decision support. The emphasis is on providing a summary of these applications with a classification according to the case study type, machine learning method, case study location, and performance metrics. The review considers documents published in the last four years, using a sample of 135 documents (review articles and research articles). It is concluded that the adoption of machine learning methods may contribute to enhancing support in different fire management phases.
ICD Outcome in Pediatric Cardiomyopathies
Authors: Silvetti Massimo Stefano , Tamburri Ilaria , Campisi Marta , Saputo Fabio Anselmo , Cazzoli Ilaria , Cantarutti Nicoletta , Cicenia Marianna , Adorisio Rachele , Baban Anwar , Ravà Lucilla , Drago Fabrizio
Published: January 2022

Background: Pediatric patients with cardiomyopathies are at risk of malignant arrhythmias and sudden cardiac death (SCD). An ICD may prevent SCD. The aim of this study was to evaluate ICD implantation outcomes, and to compare transvenous and subcutaneous ICDs (S-ICDs) implanted in pediatric patients with cardiomyopathies. Methods: The study is single center and retrospective, and includes pediatric patients with cardiomyopathies who required ICD implantation (2010–2021). Outcomes were recorded for appropriate/inappropriate ICD therapy and surgical complications. Transvenous ICD and S-ICD were compared. Data are presented as median values (25th–75th centiles). Results: Forty-four patients with cardiomyopathies (hypertrophic 39%, arrhythmogenic 32%, dilated 27%, and restrictive 2%) underwent transvenous (52%) and S-ICD (48%) implantation at 14 (12–17) years of age, mostly for primary prevention (73%). The follow-up period was 29 (14–60) months. Appropriate ICD therapies were delivered in 25% of patients, without defibrillation failures. Lower age at implantation and secondary prevention were significant risk factors for malignant ventricular arrhythmias that required appropriate ICD therapies. ICD-related complications were surgical complications (18%) and inappropriate shocks (7%). No significant differences in outcomes were recorded, either when comparing transvenous and S-ICD or comparing the different cardiomyopathies. Conclusions: In pediatric patients with cardiomyopathy, ICD therapy is effective, with a low rate of inappropriate shocks. Neither ICD type (transvenous and S-ICDs) nor the cardiomyopathies subgroup revealed divergent outcomes.
The Long-Term Effects of 12-Week Intranasal Steroid Therapy on Adenoid Size, Its Mucus Coverage and Otitis Media with Effusion: A Cohort Study in Preschool Children
Authors: Zwierz Aleksander , Masna Krystyna , Domagalski Krzysztof , Burduk Paweł
Published: January 2022

Background: The purpose of this study is to analyse the long-term effects of a 12-week course of topical steroids on adenoid size and its mucus using endoscopy and on middle ear effusion measured by tympanometry. Methods: The study presents an endoscopic choanal assessment of the change in adenoid size (adenoid to choanae ratio, A/C ratio) and its mucus coverage in 165 children with Grade II and III adenoid hypertrophy three to six months after finishing a 12-week course of intranasal steroid treatment with mometasone furoate. Additionally, tympanometry was performed to measure middle ear effusion. Changes in the tympanograms were analysed. Results: The mean A/C ratio before treatment was 65.73%. Three to six months after finishing a 12-week course of intranasal steroid treatment, the mean A/C ratio decreased to 65.52%, although the change was not statistically significant (p = 0.743). There was no change in adenoid mucus according to the MASNA scale before and three to six months after the end of the steroid treatment (p = 0.894). Long-term observations of tympanograms before and three to six months after the end of the treatment did not show improvement (p = 0.428). Conclusions: The results indicate that there was no effect of topical steroids on adenoid size, its mucus and otitis media with effusion (OME) three to six months after finishing a 12-week course of treatment. In the light of performed study, decision of adenoidectomy and tympanostomy should not be procrastinated.
Effect of Body Composition Change during Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma
Authors: Onishi Sachiyo , Tajika Masahiro , Tanaka Tsutomu , Yamada Keisaku , Kamiya Tomoyasu , Abe Tetsuya , Higaki Eiji , Fujieda Hironori , Nagao Takuya , Inaba Yoshitaka , Muro Kei , Shimizu Masahito , Niwa Yasumasa
Published: January 2022

Effects of changes in body composition during neoadjuvant chemotherapy (NAC) on perioperative complications and prognosis are unknown in patients with esophageal squamous cell carcinoma (ESCC). A total of 175 patients who underwent surgery for ESCC in our hospital between 2016 and 2019 were examined. The psoas muscle index (PMI) was calculated from the total psoas muscle area, and the visceral fat mass (VFM) at the umbilical level was measured. We defined body composition change (BCC) group as those with increased VFM of ≥ 3% and decreased PMI of ≥ 3% during NAC. Sarcopenia (S) was defined as PMI < 5.89 (male) and <4.06 (female). Nutritional assessment using the Subjective Global Assessment tool was performed upon admission. The percentages of BCC group, pre-NAC S, and post-NAC S was 32.5%, 79.4%, and 80.0%, respectively. BCC group had significantly more postoperative complications (p < 0.01) and longer hospital stays (p = 0.03) than groups pre-NAC S and post-NAC S. Overall survival (OS) analysis using the Cox hazard model showed that stage III (p < 0.01) and post-NAC S (p = 0.03) were poor prognostic factors. Changes in body composition during NAC affected perioperative complications and prognosis of patients with ESCC.
Antithrombotic Strategies in Patients with Atrial Fibrillation and Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention
Authors: De Luca Leonardo , Mistrulli Raffaella , Veneziano Francesco Antonio , Grigioni Francesco , Volpe Massimo , Musumeci Francesco , Gabrielli Domenico
Published: January 2022

Patients with atrial fibrillation (AF) are at increased risk for coronary artery disease (CAD). After percutaneous coronary intervention (PCI), the antithrombotic therapy consists of a combination of anticoagulant and antiplatelet agents to reduce the ischemic and thromboembolic risk, at the cost of increased bleeding events. In the past few years, several randomized clinical trials involving over 12,000 patients have been conducted to compare the safety of vitamin K antagonist (VKA) and direct-acting oral anticoagulants (DOACs) in association with a single- or double-antiplatelet agent, in the so-called dual- (DAT) or triple-antithrombotic therapy (TAT). These studies and several meta-analyses showed a consistent benefit for reducing bleeding events of DAT over TAT and of DOAC over VKA, without concerns about ischemic endpoints, except for a trend for increased stent thrombosis risk. The present paper examines current international guidelines’ recommendations and reviews clinical trials, meta-analyses, and observational studies conducted on AF patients treated with DAT or TAT after PCI for acute coronary syndromes.
Brain Volume Loss Can Occur at the Rate of Normal Aging in Patients with Multiple Sclerosis Who Are Free from Disease Activity
Authors: Temmerman Joke , Van Der Veken Floris , Engelborghs Sebastiaan , Guldolf Kaat , Nagels Guy , Smeets Dirk , Allemeersch Gert-Jan , Costers Lars , D’hooghe Marie B. , Vanbinst Anne-Marie , Van Schependom Jeroen , Bjerke Maria , D’haeseleer Miguel
Published: January 2022

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and degenerative disorder of the central nervous system. Accelerated brain volume loss (BVL) has emerged as a promising magnetic resonance imaging marker (MRI) of neurodegeneration, correlating with present and future clinical disability. We have systematically selected MS patients fulfilling ‘no evidence of disease activity-3′ (NEDA-3) criteria under high-efficacy disease-modifying treatment (DMT) from the database of two Belgian MS centers. BVL between both MRI scans demarcating the NEDA-3 period was assessed and compared with a group of prospectively recruited healthy volunteers who were matched for age and gender. Annualized whole brain volume percentage change was similar between 29 MS patients achieving NEDA-3 and 24 healthy controls (−0.25 ± 0.49 versus −0.24 ± 0.20, p = 0.9992; median follow-up 21 versus 33 months; respectively). In contrast, we found a mean BVL increase of 72%, as compared with the former, in a second control group of MS patients (n = 21) whom had been excluded from the NEDA-3 group due to disease activity (p = 0.1371). Our results suggest that neurodegeneration in MS can slow down to the rate of normal aging once inflammatory disease activity has been extinguished and advocate for an early introduction of high-efficacy DMT to reduce the risk of future clinical disability.
Volumetric Flow Assessment in Doppler Ultrasonography in Risk Stratification of Patients with Internal Carotid Stenosis and Occlusion
Authors: Kaszczewski Piotr , Elwertowski Michał , Leszczyński Jerzy , Ostrowski Tomasz , Gałązka Zbigniew
Published: January 2022

(1) Background: Alterations of blood flow volume in extracranial arteries may be related to the risk of occurrence of neurological symptoms. The aim of this study was the estimation of cerebral blood flow (CBF) in Doppler ultrasonography, as well as comparison of the flow volume in asymptomatic patients over 65 years old with ≥50%, and symptomatic patients with ≥70% internal carotid artery (ICA) stenosis, in order to assess whether the changes in the CBF correlates with the presence of neurological symptoms. (2) Methods: 308 patients over 65 years old were included in the retrospective cohort observational study: 154 asymptomatic with ≥50% ICA stenosis, 123 healthy volunteers, and 31 symptomatic referred for surgical treatment. The study group was split according to ICA stenosis (50–69%, 70–99% and occlusion). In all patients an extensive Doppler ultrasound examination with measurements of flow volume in common, internal, external carotid (ECA) and vertebral arteries (VA) was performed. (3) Results: Among asymptomatic (A) and symptomatic (S) patients with carotid stenosis 3 subgroups were identified: 57/154—37% (A) and 8/31—25.5% (S)—with significantly increased flow volume (CBF higher than reference range: average CBF + std. dev in the group of healthy volunteers), 67/154—43.5% (A) and 12/31—39% (S)—with similar to reference group flow volume (CBF within range average ± std.dev), and 30/154—19.5% (A) and 11/31—35.5% (S)—with decreased flow volume in extracranial arteries (flow lower than average-std.dev. in healthy volunteers). In symptomatic patients the percentage of patients with significant compensatory increased flow tends to raise with the severity of the stenosis, while simultaneous decline of number of patients with mild compensation (unchanged total CBF) is observed. The percentage of patients without compensation remains unchanged. In the group referred for surgical treatment (symptomatic, ≥70% ICA stenosis) the percentage of patients with flow compensation is twice as low as in the asymptomatic ones with similar degree of the ICA stenosis (8/31—25.8% vs. 26/53—49%, p = 0.04). Compensatory elevated flow was observed most frequently in ECA. (4) Conclusions: The presence of significant volumetric flow compensation has protective influence on developing ischaemic symptoms, including TIA or stroke. The assessment of cerebral inflow in Doppler ultrasonography may provide novel and easily accessible tool of identifying patients prone to cerebral ischaemia. The multivessel character of compensation with enhanced role of ECA justifies the importance of including this artery in the estimation of CBF.
Usefulness of Cardiac Computed Tomography in Coronary Risk Prediction: A Five-Year Follow-Up of the SPICA Study (Secure Prevention with Imaging of the Coronary Arteries)
Authors: Viladés-Medel David , Dégano Irene R. , Subirana Isaac , Descalzo Martin , Padilla Mireia , Mundet Xavier , Carreras Costa Francesc , Alomar Serrallach Xavier , Camps Anna , Elosua Roberto , Marrugat Jaume , Leta Petracca Rubén
Published: January 2022

Accurate identification of individuals at high coronary risk would reduce acute coronary syndrome incidence and morbi-mortality. We analyzed the effect on coronary risk prediction of adding coronary artery calcification (CAC) and Segment Involvement Score (SIS) to cardiovascular risk factors. This was a prospective cohort study of asymptomatic patients recruited between 2013–2017. All participants underwent a coronary computed tomography angiography to determine CAC and SIS. The cohort was followed-up for a composite endpoint of myocardial infarction, coronary angiography and/or revascularization (median = five years). Discrimination and reclassification of the REGICOR function with CAC/SIS were examined with the Sommer’s D index and with the Net reclassification index (NRI). Nine of the 251 individuals included had an event. Of the included participants, 94 had a CAC = 0 and 85 a SIS = 0, none of them had an event. The addition of SIS or of SIS and CAC to the REGICOR risk function significantly increased the discrimination capacity from 0.74 to 0.89. Reclassification improved significantly when SIS or both scores were included. CAC and SIS were associated with five-year coronary event incidence, independently of cardiovascular risk factors. Discrimination and reclassification of the REGICOR risk function were significantly improved by both indexes, but SIS overrode the effect of CAC.
Hyaluronic Acid/Collagenase Ointment in the Treatment of Chronic Hard-to-Heal Wounds: An Observational and Retrospective Study
Authors: De Francesco Francesco , De Francesco Marialuisa , Riccio Michele
Published: January 2022

Background: Wound bed preparation is an important concept in clinical practice and is related to adequate debridement. The use of proteolytic enzymes is an established method of enzymatic wound debridement, especially in hard-to-heal ulcers that are unresponsive to normal healing procedures and progress. The TIME framework (tissue, inflammation/infection, moisture balance, and edge of wound) offers an appropriate strategy to eliminate resistance to healing, as well as maximizing the healing process. Maintenance debridement, as opposed to sporadic debridement, may be proposed in preserving an adequate wound bed towards complete recovery. Collagenase has been effective in debridement due to its ability to degrade collagen and elastin. In this clinical context, collagenase taken from Vibrio alginolitycus is the most favorably expressed enzymatic debriding agent. Methods: This retrospective observational study evaluates the efficacy of an ointment based on hyaluronic acid and collagenase (Bionect Start®), considering a reduced healing time and greater healing quality. We included 70 patients with chronic wounds of different etiologies, including diabetes mellitus (20), post-traumatic ulcers (35), chronic burns of degrees I and II (10), and pressure ulcers (5). We analyzed wound characteristics using the wound bed score (WBS) concept, healing time, as well as operator and patient satisfaction. Results: Frequency of debridement efficacy in terms of wound bed cleansing varied from 26% after 2 weeks to 93% after 4 weeks. We observed complete healing in 62 patients within an eight-week period. The overall operator and patient satisfaction after 8 weeks were 100% and 90%, respectively. Moreover, all patients reported less pain. Conclusions: A combined action of hyaluronic acid and collagenase ointment demonstrated a reduction in healing time while improving healing quality, with a decrease in pain.
Cybersecurity Practices for Social Media Users: A Systematic Literature Review
Authors: Herath Thilini B. G. , Khanna Prashant , Ahmed Monjur
Published: January 2022

In this paper, we present secondary research on recommended cybersecurity practices for social media users from the user’s point of view. Through following a structured methodological approach of the systematic literature review presented, aspects related to cyber threats, cyber awareness, and cyber behavior in internet and social media use are considered in the study. The study presented finds that there are many cyber threats existing within the social media platform, such as loss of productivity, cyber bullying, cyber stalking, identity theft, social information overload, inconsistent personal branding, personal reputation damage, data breach, malicious software, service interruptions, hacks, and unauthorized access to social media accounts. Among other findings, the study also reveals that demographic factors, for example age, gender, and education level, may not necessarily be influential factors affecting the cyber awareness of the internet users.