bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapatriements sanitaires à l’échelon d’un service d’orthopédietraumatologie durant trois années.
Authors: MARTIN M. , BAJARD X. , BARTHÉLÉMY R. , BAUER B. , VAN GAVER E. , DE LOYNES B. , DAILLIER P. , RIGAL S.
Published: April 2023

Le but de cette étude prospective est de retracer durant trois ans, le parcours médico-chirurgical des patients militaires
faisant l’objet d’une évacuation sanitaire, adressés dans un service d’orthopédie-traumatologie. L’enregistrement des
données est effectué de 2007 à 2009. Les étapes du patient, du traumatisme initial au suivi post opératoire, sont relevées
avec les dates clés. L’exploitation des données est uniquement dans un but descriptif, la série étant peu homogène. Les
lésions des 465 patients sont plus fréquentes aux membres inférieurs et une fréquence élevée des blessés par projectiles
balistiques est notable depuis l’installation des troupes françaises en Afghanistan. Le délai moyen d’évacuation est de
14 jours. Les étiologies sont dominées par la traumatologie sportive et les accidents domestiques. On note que 132 patients
ont été opérés avant leur évacuation dont la majorité dans des formations sanitaires de l’armée française. Dans le service,
155 interventions ont été réalisées dans cette série. Le délai d’évacuation est à pondérer par les délais de prise en charge
spécialisée en outre-mer et les contraintes logistiques du transport aérien. Les traumatismes graves pris en charge dans les
hôpitaux civils ou dans les formations médico-chirurgicales militaires ont bien évoluées. Les structures de type Groupement
médico-chirurgical, bien équipées, permettent également un long suivi et l’évacuation peut être alors reportée.
Phénomènes de groupes et traumatisme psychique : une des faces cachées du traumatisme
Authors: THOMAS G. , CATRIN E. , GAULT C. , LEDUC C.
Published: April 2023

Parmi nos patients militaires présentant un traumatisme psychique, rares sont ceux qui ne nous parlent pas de leur
expérience du groupe. Par ailleurs, l’accès que permet dorénavant l’envoi de psychiatres au contact des troupes nous
permet d’avoir un aperçu de la richesse des échanges dans les groupes constitués, premiers lieux de résolution des
conflits et d’expression de la souffrance individuelle. Nous proposons dans ce travail d’aborder différents aspects. Dans
un premier temps, nous nous intéresserons aux réactions du groupe suite à un évènement qui le confronte à la mort. La
définition de l’institution militaire et la prise en compte de ses spécificités nous permettra d’appréhender les particularités
de ces réactions. Puis à l’aide d’exemples cliniques nous soulignerons les attentes des patients traumatisés à l’égard du
groupe militaire et leur isolement face à l’incommunicabilité du traumatisme psychique. Nous essaierons enfin de
caractériser comment le groupe peut être protecteur vis-à-vis de l’effraction traumatique. Nous poserons en ce sens
quelques bases psychopathologiques, afin d’en tirer des enseignements pour notre pratique et celle de nos confrères
médecins d’unités.
Evaluations de la qualité rédactionnelle des prescriptions médicamenteuses et des interventions pharmaceutiques à l’HIA Legouest à Metz.
Authors: CHABI Y. , GALVEZ O. , GRANET J.-P. , MATTON T. , MERLIN C. , REY P.
Published: April 2023

L’analyse pharmaceutique des prescriptions est une procédure d'évaluation s’inscrivant dans une démarche de qualité.
Notre travail avait pour objectif d'apprécier l'impact clinique des interventions pharmaceutiques sur les prescriptions
médicamenteuses à l'Hôpital d’instruction des armées Legouest à Metz. Un audit clinique de pratique réalisé en deux
phases à quatre ans d'intervalle a permis d’exploiter successivement 137 ordonnances de sortie d'hospitalisation et 717
ordonnances de patients hospitalisés dans huit services cliniques. Les non conformités concernaient majoritairement
l’absence de la forme galénique dans 61 % des ordonnances de sortie et sur toutes les ordonnances d’hospitalisation ainsi
que l’absence du dosage des médicaments pour 8 % des ordonnances de sortie et 3,6 % des ordonnances
d’hospitalisation. Deux cent sept interventions pharmaceutiques étaient proposées, dont 60 % de substitutions de
molécules, 19 % d’optimisation des modalités de traitement et 10,7 % d’adaptation posologique. Ces interventions
étaient acceptées par les prescripteurs dans 86,8 % des cas, mais leur véritable prise en compte reste à évaluer.
Pandémie grippale 2009 dans les armées : l’expérience de l’épidémiologiste.
Authors: MAYET A. , MEYNARD J.-B. , MANET G. , HAUS-CHEYMOL R. , DECAM C. , LIGIER C. , GACHE K. , DIA A. , DE LAVAL F. , POMMIER DE SANTI V. , QUEYRIAUX B. , CHAUDET H. , DEPARIS X. , MIGLIANI R.
Published: April 2023

L’objectif de cet article était de décrire les actions et études entreprises par les épidémiologistes militaires durant la
pandémie de grippe A (H1N1) pdm09 et de dresser un inventaire de leurs principaux résultats. Deux systèmes pérennes
de surveillance de la grippe existent dans les armées : la surveillance épidémiologique des armées, système permanent, et
le système militaire d'observation de la grippe, système saisonnier. La menace pandémique a conduit à réactiver le
système militaire d'observation de la grippe de façon précoce puis à mettre en place un système de surveillance
quotidienne. En France métropolitaine, la flambée épidémique des infections respiratoires a été observée début
novembre, le pic épidémique étant observé début décembre. En parallèle, une surveillance de la campagne de vaccination
pandémique (49 138 doses de vaccin injectées) été conduite, retrouvant 155 cas d’effets indésirables du vaccin. Une étude
d’évaluation des différents systèmes de surveillance a enfin été conduite. Le système militaire d'observation de la grippe
apparaissait comme le système le plus performant du point de vue de la santé publique tandis que la surveillance
quotidienne était perçue par les décideurs comme un outil d’information indispensable pour la conduite des opérations.
Les sacs médicaux à visée opérationnelle dans le Service de santé des armées
Authors: LEBARS R. , CONTE B. , POLLY V.
Published: April 2023

À la lumière des enseignements issus des opérations extérieures récentes, notamment en Afghanistan, le Service de santé
des armées a procédé à la recherche de nouveaux contenants médicaux, afin de porter au plus près du combattant blessé
les matériels techniques indispensables à une médicalisation de l’avant. Il s’est orienté non pas vers un sac, mais une
gamme de plusieurs contenants compatibles, pouvant s’adapter entre eux, afin de répondre à la diversité des situations
rencontrées par les personnels « santé » en opération extérieure. L’agencement de ces sacs et leur composition sont
laissés à l’initiative des personnels.
Evaluation comparative de deux garrots « tourniquet » en auto-application et en ambiance tactique
Authors: DONAT A. , KEDZIEREWICZ R. , RAMDANI E. , LOHÉAS D. , LEROULLEY D. , PRECLOUX P.
Published: April 2023

L’hémorragie des extrémités représente à ce jour une cause majeure de décès au combat. La pose précoce d’un garrot représente une des bases du sauvetage au combat. Nous comparons l’efficacité du modèle actuellement en dotation dans l’armée française : le SOFFT-NHTM à celle de son évolution récente : le SOFTT-WTM. Contrairement à la majorité des études similaires, réalisées en laboratoire, ces garrots sont ici testés dans des conditions environnementales proches de celle du combat. Il apparaît alors qu’en auto-application, en tenue de combat complète et après un effort physique, l’efficacité des dispositifs testés ne dépasse pas 20 %. Ces résultats plaident pour un entraînement ciblé des combattants à la pose de garrots dans des conditions défavorables.
Etude criminalistique des morsures humaines
Authors: VETTER V. , DENHEZ F. , GIRAUD O. , ZIMMERMANN P.
Published: April 2023

L’analyse criminalistique de morsure fait appel à des techniques variées et complémentaires. Celle-ci débute par un examen macroscopique lésionnel validant les possibilités d’exploitation des marques complété par un bilan photographique numérique régional et rapproché au rapport 1/1. Un prélèvement salivaire sur morsure est indiqué en l’absence de souillure (habits ou désinfection le plus souvent) dès le début de la prise en charge. La conservation tissulaire peut être prolongée par prélèvement et fixation sur cadre, la transillumination aidant à l’objectivation de la trace et l’histopathologie à sa datation.
L’étude de rapprochement d’une morsure avec une denture pouvant y correspondre est réalisée par un examen clinique de suspect jaugeant la faisabilité de l’acte complété par une analyse de superposition photographique à grandeur réelle de son calque de contours dentaires avec l’image lésionnelle supposée pouvoir être en rapport. La contribution récente de techniques d’acquisition en 3D (scanner et dispositifs photographiques stéréophotogrammétriques) permet d’affiner les comparaisons trace-denture, plus particulièrement sur surfaces cutanées courbes ou peu fixées.
Linear finite functional in the weighted Sobolev space
Authors:   Tomsk Polytechnic University, Korytov Igor K.
Published: April 2023

In this paper, a representation of a linear functional in the weighted Sobolev space is obtained. The space is normed without use of pseudodifferential operators. The norm contains partial derivatives of all intermediate orders of the test function. The Sobolev space is considered to be of non-Hilbert type. First, we deduce the representation of linear functional via a boundary element of the test space. The boundary element corresponds to the given functional. This way, referring to Clarkson’s inequalities, we prove the uniqueness of the boundary element. Then, to obtain a condition for the boundary element, we differentiate the function built based on the norm. The result leads to a representation of an arbitrary linear functional via the boundary element. When considering the boundary element as unknown, the representation performs as a nonlinear differential equation. Second, we consider a finite linear functional. The extreme function of such a functional was built in our earlier papers. The extreme function is expressed via convolution of the fundamental solution of a linear partial differential equation with a given functional. The functional performs as a distribution in the convolution. Convolution exists if the linear functional is finite. Using this fact, we prove that the representation of a finite linear functional via the boundary element is identical to the representation via the extreme function.
Experimental and theoretical studies of the flow around a sphere with account for gas injection from its surface
Authors:   Tomsk State University, Arkhipov Vladimir A. , Basalaev Sergey A. ,   Tomsk State University, Kostyushin Kirill V. ,   Tomsk State University, Perfil’eva Kseniya G. ,   Tomsk State University, Usanina Anna S. ,   Tomsk State University
Published: April 2023

The results of the experimental and theoretical studies of the gas flow around a solid sphere under conditions of mass outflow from its surface are presented. A new experimental setup and a method for studying the flow around a solid sphere during the gas injection from its surface are proposed with the aim of improving the accuracy of determining the drag coefficient. In the range of the Reynolds number (Re = 133÷667), experimental results show that the drag coefficient decreases at the gas injection from the surface of the sphere. Moreover, the drag coefficient decreases with an increase in the density of the injected air flow at the fixed Reynolds number. Numerical simulation of a two-phase flow around a sphere with the gas injection from its surface is carried out for two calculation cases: with a uniform gas outflow from the surface of a porous sphere and with gas injection from perforated holes on the sphere surface. The numerical calculation results for the case of gas injection from the holes of the sphere are in quantitative and qualitative agreement with the experimental data.
UAB-VU BIOMIC Preparation of Left Fresh Frozen Eye v1
Authors: Anderson David
Published: April 2023

Scope: This protocol describes the process of procuring donor eyes from Advancing Sight Network, the processing and freezing of the left eye, and the sectioning of tissue for the HuBMAP Eye project. Glossary of Terms (Figure 1): Anterior- Refers to the front part of the eye – right side of Figure 1 – the light shines in from this aspect Anterior segment - includes iris, cornea, pupil aqueous humor, and the conjunctiva (not shown). Cornea- Clear, and continuous with sclera; allows light to enter into the eye to the retina, at the back of the fundus. Choroid- Vascular bed of blood vessels to nourish the posterior half of the retina. Fovea-Small depression in the retina, in the back of the eye, specialized for detailed and color vision. Fundus- A term used for the lining of any organ. The ocular fundus consists of the neurosensory retina, RPE (retinal pigmented epithelium) and the choroid. Iris- Controls the amount of light entering the eye. Lens- Changes shape to allow viewing of close or distant objects. Macula lutea – yellow spot due to xanthophyll pigments, containing the fovea Optic nerve- Transfers visual information from the retina to the brain. Posterior- refers to the back part of the eye – left side of Figure 1. Posterior segment - All parts of the eye that are located behind the lens. Usually referring to the retina between the optic disc and the macula. Pupil- Opening formed by the iris, varies in size with ambient light. Retina- lining the fundus in the back of the eye; receives light signals and convert them into neural signals and send those signals through the optic nerve back to the brain. Sclera- White part of the eye that maintains its shape, for optical alignment and muscle attachment.
Equidyn application tutorial v1
Authors: Janeiro Valenciano Paola
Published: April 2023

The Equidyn application was developed to evaluate dynamic balance through smartphone-based trunk accelerometry. The evaluation protocol had as main characteristic a reduced support base while having standardized movement amplitude and rhythm. The evaluation protocol was composed of a series of seven tasks: 1. One-leg motionless balance supported on the right leg, 2. One-leg motionless balance supported on the left leg, 3. Anteroposterior (AP) oscillation of the left leg while supported on the right leg, 4. AP oscillation of the right leg while supported on the left leg, 5. Mediolateral (ML) oscillation of the left leg while supported on the right leg, 6. ML oscillation of the right leg while supported on the left leg, 7. Sit-to-stand with bipedal support. Markers were made through adhesive strips, attached 20-cm apart in parallel on the ground. Proximal markers were used as reference for positioning the supporting foot, while the distal AP marker was attached in front of the participant, and the distal ML marker was attached laterally regarding participant’s spatial orientation. These markers were used to achieve the same leg movement amplitude across participants. The dynamic tasks were paced through beeps emitted by a digital metronome set at the frequency of 1-Hz. Each marker touching in the leg sway tasks, and either sitting or full standing phases of the sit-to-stand task were to be timed with metronome beeps. Tasks were assessed through three consecutive trials, lasting 15 s each.Intratest between-trial rest intervals were 30-s long, while 60-s intervals were provided between tests. The complete assessment lasted approximately 20 min. Participants’ responses are administered through a smartphone application named Equidyn, designed and developed for the Android system.The root mean square (RMS) of acceleration in the AP and ML directions was analyzed in each task.
Schistosoma mansoni cercariae transformation (without needle) v2
Authors: K Buddenborg Sarah
Published: April 2023

Free-living aquatic S. mansoni cercariae transform into the first intramammalian stage, called schistosomula or somules, by burrowing in the host skin. Upon contact, cercariae begin to enter the skin and lose their tails, becoming schistosomula. Somules migrate through the epidermis to the dermis to find a small venule or lymphatic vessel to enter the vasculature. Transformation of cercariae to schistosomula can be mimicked in the laboratory by centrifuging cercariae to remove tails and then culturing the somules in somule media. This method is particularly useful when the number of cercariae is low (i.e. clonal cercariae from an individual snail). Somules can be cultured for several weeks with regular media changes.
Fixation and Embedding of Eyes at UAB v1
Authors: D. Messinger Jeffrey
Published: April 2023

The accession and fixation of whole human eye specimens at University of Alabama Birmingham as part of the Human Biomolecular Atlas Project.
FastDNA SPIN Kit for Soil v1
Authors: not provided leighton.r.king
Published: April 2023

The FastDNATM SPIN Kit for Soil quickly and efficiently isolates PCR-ready genomic DNA directly from soil samples in less than 30 minutes. Designed for use with the FastPrep® instruments from MP Biomedicals, plant and animal tissues, bacteria, algae, fungal spores and other members of a soil population are easily lysed within 40 seconds. These benchtop devices use a unique, optimized motion to homogenize samples by multidirectional, simultaneous impaction with lysing matrix particles. FastPrep instruments provide a quick, efficient and highly reproducible homogenization that surpasses traditional extraction methods using enzymatic digestion, sonication, blending, douncing and vortexing. Samples are placed into 2.0 mL tubes containing Lysing Matrix E, a mixture of ceramic and silica particles designed to efficiently lyse all soil organisms, including historically difficult sources, such as eubacterial spores and endospores, gram positive bacteria, yeast, algae, nematodes and fungi. Homogenization in a FastPrep instrument with Lysing Matrix E takes place in the presence of MT Buffer and Sodium Phosphate Buffer, reagents carefully developed to protect and solubilize nucleic acids and proteins upon cell lysis. These reagents work synergistically to allow extraction of genomic DNA with minimal RNA contamination. Following lysis, samples are centrifuged to pellet soil, cell debris and lysing matrix. DNA is purified from the supernatant with the Binding Matrix FastDNA procedure using SPIN filters. Eluted DNA is ready for PCR, restriction digest, electrophoresis and any other desired application.
Processamento de actígrafos pós-coleta - ActTrust v4
Authors: Vartanian Daniel
Published: April 2023

Este protocolo faz parte do processo de coleta de dados actigráficos do Grupo Interdisciplinar de Pesquisa em Ritmos Biológicos (GIPERBIO). Ele foi desenvolvido para os actígrafos da empresa Condor Instruments. Algumas das configurações mencionadas podem ser específicas desses aparelhos. Caso este protocolo seja útil para você, por favor, notifique os autores clicando no botão WORKS FOR ME no topo deste documento. Isso faz uma grande diferença. Se você não é um membro ou parceiro do GIPERBIO, você pode utilizar este protocolo como referência para o processamento dos seus equipamentos. Nesse caso, por favor, não envie os formulários mencionados neste ou em outros protocolos relacionados ao processo. Se você utilizar os protocolos do GIPERBIO em sua pesquisa, considere citá-los na seção de métodos do seu estudo. Nós nos esforçamos bastante para elaborar e manter protocolos de acesso aberto à comunidade científica. Você pode encontrar a citação deste protocolo na aba METADATA. Para visualizar o fluxograma do processo e outros protocolos relacionados, consulte a aba GUIDELINES. Caso tenha dúvidas ou sugestões, crie um comentário no protocolo ou entre em contato com um dos autores. --- This protocol is part of the process for collecting actigraphy data by the Interdisciplinary Research Group on Biological Rhythms (GIPERBIO). It is designed for Condor Instruments actigraphs, and some of the settings mentioned may be specific to these devices. If this protocol is helpful, please notify the authors by clicking the WORKS FOR ME button at the top of this document. Your feedback makes a significant difference. If you are not a member or partner of GIPERBIO, you may use this protocol as a reference for processing your equipment. However, please do not send the forms mentioned in this or other protocols related to the process. If you use GIPERBIO protocols in your research, please consider citing them in the methods section of your study. We have put a lot of effort into designing and maintaining open-access protocols for the scientific community. You can find the citation of this protocol in the METADATA tab. Please refer to the GUIDELINES tab to view the process flowchart and other related protocols. If you have any questions or suggestions, please create a comment on the protocol or contact one of the authors.
Modified Organic Extraction Protocol (Pedersen et al., 2016) v1
Authors: Pedersen Mikkel
Published: April 2023

A modified version of the organic extraction protocol used in Wales et al., 2014. Protocol successful at reconstructing the biodiversity of 15 kya sediment core, including a few fish species
QIAGEN DNeasy PowerSoil Pro Kit v1
Authors: not provided QIAGEN
Published: April 2023

For the isolation of microbial genomic DNA from all soil types, including difficult samples such as compost, sediment, and manure. The DNeasy PowerSoil Pro Kit comprises a novel and proprietary method for isolating microbial genomic DNA from environmental samples. The kit uses QIAGEN’s secondgeneration Inhibitor Removal Technology® (IRT) and is intended for use with environmental samples containing high humic acid content, including difficult soil types such as compost, sediment, and manure. Other more common soil and stool types have also been used successfully with this kit. Improved IRT combined with more efficient bead beating and lysis chemistry yields high-quality DNA that can be used immediately in downstream applications, including PCR, qPCR, and next-generation sequencing (16S and whole genome). As of April, 2023 - no published studies successfully detecting fish sedDNA using only this kit (see Lakes ABPS protocol). Unpublished studies report poor DNA yields and low concentrations of fish sedDNA. Other studies targeting migratory fish sedDNA during a spawning run found sufficient fish sedDNA concentrations following this protocol.
QIAGEN DNeasy PowerSoil Kit v1
Authors: not provided QIAGEN
Published: April 2023

For the isolation of microbial genomic DNA from all soil types The DNeasy PowerSoil Kit comprises a novel and proprietary method for isolating genomic DNA from environmental samples using patented Inhibitor Removal Technology® (IRT). This kit is intended for use with environmental samples containing high humic acid content, including difficult soil types such as compost, sediment and manure. Other more common soil types have also been used successfully with this kit. The isolated DNA has a high level of purity, which allows for more successful PCR amplification of organisms from the sample. PCR analysis has been performed to detect a variety of organisms including bacteria (e.g., Bacillus subtilis, Bacillus anthracis), fungi (e.g., yeasts, molds), algae and actinomycetes (e.g., Streptomyces). Protocol used successfully to detect target fish species sedDNA by Olajos et al., 2018; Nelson-Chorney et al., 2019; Thomson-Laing et al., 2020; Shiragaki et al., 2021; and Naro-Maciel et al., 2022
Conexão do actígrafo ao computador - ActTrust v3
Authors: Vartanian Daniel
Published: April 2023

Este protocolo faz parte do processo de coleta de dados actigráficos do Grupo Interdisciplinar de Pesquisa em Ritmos Biológicos (GIPERBIO). Ele foi desenhado para os actígrafos provenientes da companhia Condor Instruments. Algumas das configurações mencionadas podem ser específicas desses aparelhos. Se este protocolo te ajudar, por favor notifique os autores ao clicar no botão WORKS FOR ME no topo deste documento. Isso faz muita diferença. Se você não é membro ou parceiro do GIPERBIO, você pode utilizar este protocolo como referência para o processamento de seus equipamentos. Neste caso, por favor, não envie os formulários mencionados neste ou em outros protocolos relacionados ao processo. Se você utilizar os protocolos do GIPERBIO em sua pesquisa, por favor considere citá-los na seção de métodos de seu estudo. Nós nos esforçamos bastante para elaborar e manter protocolos de acesso aberto à comunidade científica. Você pode encontrar a citação deste protocolo na aba METADATA. Consulte a aba GUIDELINES para visualizar o fluxograma do processo e os demais protocolos relacionados. Para dúvidas ou sugestões, crie um comentário no protocolo ou entre em contato com um dos autores. --- This protocol is part of the process for collecting actigraphy data made by the Interdisciplinary Research Group on Biological Rhythms (GIPERBIO). It was designed for Condor Instruments actigraphs. Some of the settings mentioned may be specific to these devices. If this protocol helps you, please notify the authors by clicking the WORKS FOR ME button at the top of this document.That makes a lot of difference. If you are not a member or partner of GIPERBIO, you can use this protocol as a reference for processing your equipment. In this case, please do not send the forms mentioned in this or other protocols related to the process. If you use the GIPERBIO protocols in your research, please consider citing them in the methods section of your study. We put a lot of effort into designing and maintaining open access protocols for the scientific community. You can find the citation of this protocol in the METADATA tab. Check the GUIDELINES tab to view the process flowchart and other related protocols. For questions or suggestions, create a comment on the protocol or contact one of the authors.
Investigating the Nonlinear Relationship Between Car Dependency and the Built Environment
Authors: Cao Jun , Jin Tanhua , Shou Tao , Cheng Long , Liu Zhicheng , Witlox Frank
Published: April 2023

Car-dominated daily travel has caused many severe and urgent urban problems across the world, and such travel patterns have been found to be related to the built environment. However, few existing studies have uncovered the nonlinear relationship between the built environment and car dependency using a machine learning method, thus failing to provide policymakers with nuanced evidence-based guidance on reducing car dependency. Using data from Puget Sound regional household travel surveys, this study analyzes the complicated relationship between car dependency and the built environment using the gradient boost decision tree method. The results show that people living in high-density areas are less likely to rely on private cars than those living in low-density neighborhoods. Both threshold and nonlinear effects are observed in the relationships between the built environment and car dependency. Increasing road density promotes car usage when the road density is below 6 km/km2. However, the positive association between road density and car use is not observed in areas with high road density. Increasing pedestrian-oriented road density decreases the likelihood of using cars as the main mode. Such a negative effect is most effective when the pedestrian-oriented road density is over 14.5 km/km2. More diverse land use also discourages people’s car use, probably because those areas are more likely to promote active modes. Destination accessibility has an overall negative effect and a significant threshold effect on car dependency. These findings can help urban planners formulate tailored land-use interventions to reduce car dependency.
THE FOREIGN AND THE LONELY: NATIONAL CULTURAL IDENTITY IN CHRISTOPHER ISHERWOOD’S DOWN THERE ON A VISIT
Authors:   Taras Shevchenko national University of Kyiv, Drannikov Anton
Published: April 2023

Either in the theoretical philosophical dimension of ontological and existential reflections or at the more empirical practical level of social, psychological, cultural problematics, the phenomenon of loneliness commands the attention of scholars from various domains, one of the most prominent fields of research being identity studies. This article deals with the specifics of the functioning of national cultural identity in the discourse of loneliness, typical of Christopher Isherwood's fiction. The object of the research is his 1962 novel "Down There on a Visit". With the help of a complex methodology which comprises elements of hermeneutic analysis, biographical method, close reading, and basic notions of identity studies, the representations of national cultural identity, its dynamics and transformations are examined within the problematic field of loneliness in the text. Terminological and phenomenological underpinnings of the concept of national cultural identity are established. The biographically determined aspects of the poetics and architectonics of the novel are traced based on diary and memoir sources. This involves an interpretation of the title that allows reading loneliness as the central concept of the author's intent, implemented at different levels of the text. A characterisation is made of the narrator-protagonist as well as four "antiheroes" who embody various worldviews and represent multiple modi of nationally and culturally conditioned loneliness: travellers, foreigners, refugees, etc. There are identified key ideas and themes, which allow for the actualisation of the national cultural aspect of the discourse of loneliness, are identified. Among them is the motif of journey, which is conceptualised into a metaphor of existential quest, self-reflection, self-discovery, identity formation and transformations. A special meaning is also ascribed to the concept of home, which encompasses the paradigms of societal alienation, flight to foreign lands, loss of roots as well as the closely related theme of migration with its motifs of seeking asylum, crossing and fluidity of borders, transitivity, etc.
SHEVCHENKO STUDIES QUESTIONS IN THE СORRESPONDENСE OF EMPLOYEES OF THE ALL-UKRAINIAN ACADEMY OF SCIENCES AND THE TARAS SHEVCHENKO INSTITUTE IN THE 1920S–1930S
Authors:   Shevchenko Institute of Literature, National Academy of Science of Ukraine, Karpinchuk Halyna
Published: April 2023

The article analyzes about 80 letters of Ukrainian scientists of I. Aizenshtok, D. Bagalyi, O. Doroshkevych, S. Yefremov, A. Krymskyi, V. Miiakovskyi, M. and O. Novytski, M. Plevako, P. Rulin and others. They are important source for studying their biographies, clarifying creative intentions and efforts, keep the addressee’s mood and their reactions to events or circumstances. The epistolary expanding the directions of the development of Shevchenko studies in the 1920’s and 1930’s, the difficulties of organization scientific work in the Kyiv branch of the Taras Shevchenko Institute. The letters contein new information about the peculiarities of the preparation of the Complete Collected Works of Taras Shevchenko (1927–1929; 1935–1937). The probable dates of the arrangement of the volumes, the history of the discovery and researching of the letters (vol. 3, 1929) and artistic works (vol. 8, 1932) are writing in letters. For the first time, a review of the fourth volume of the collection (the diary of the poet, 1927) by historian Mykhaylo Slabchenko is published (letter to Serhiy Yefremov dated April 4, 1927). In particular, the letters supplement information about the publication of a series of memoirs (1930–1931) dedicated to the poet, and "Kobzar" (1931) with illustrations by V. Sedlyar. From a number of ideas of Shevchenko scholars, the correspondence contains evidences about the preparation of the "Dictionary of Shevchenko’s Familiars", monographs by M. Novytskyj about the company of mochymords, collections by V. Mijakovskyj about the Cyrylo and Methodius brotherhood, the funeral and reburial of the poet etc. From the letters of M. and O. Nowytski it first became known about the plan of the scientists republish the work of O. Konyskyi "Taras Shevchenko-Hrushivskyi: a chronicle of his life and work" (1898, 1901) at the beginning of 1930’s. In the letters of O. Novytskyi a primary role is assigned to a part of Shevchenko’s creativity that was little studied at the time - painting, first of all, in mastering the etching technique. The fact of cultural and political orientation – the misunderstanding of Ukraine in the Russian world – did not go unnoticed by researchers of Shevchenko's Word (Peter Rulin's letter dated August 21, 1926). All reviewed letters are stored in Kyiv archives and mostly have not been printed. During the preparation of the article several of them were discribed for the first time and, if necessary, attributed.
Development of scalded skin syndrome in an adult patient with acquired epidermolysis bullosa after long-term treatment with methotrexate
Authors: Olisova Olga Yu. , Teplyuk Nataliа P. , Ignatiev Dmitry V. , Dunaeva Ekaterina R.
Published: April 2023

A clinical case of a patient with epidermolysis bullosa acquisita, which is a rare autoimmune disease ― 0.170.26 cases per 1 million population, with the development, most likely against the background of long-term cytostatic therapy with methotrexate, develops staphylococcal scalded skin syndrome is presented.
Staphylococcal scalded skin syndrome is a lesion that appears in 0.090.56 cases per 1 million and is predominantly observed in newborns and children under 5 years of age, and cases in adults are usually associated with immunosuppression, human immunodeficiency virus / acquired immunodeficiency syndrome, severe renal failure or malignant neoplasms.
The article presents literature data on the etiology and pathogenesis of the presented diseases, features of differential diagnosis, description of clinical and laboratory criteria, on the basis of which diagnoses are made.
This clinical case is of interest to dermatologists, as it describes the scalded skin syndrome, which is rare in everyday practice, in a patient with acquired epidermolysis bullosa, which, despite ongoing therapy, has a risk of death of up to 65%.
Chronicles of A.I. Pospelov Moscow Society of Dermatovenerologists and Cosmetologists (MSDC was founded on October 4, 1891). Bulletin of the MSDC № 1150
Authors: Yakovlev Alexey B. , Maximov Ivan S.
Published: April 2023

On December 20, 2022, the 1150th meeting of the Moscow Society of Dermatovenerologists and Cosmetologists (MSDC) named after A.I. Pospelov took place.
The meeting was held in a face-to-face format. There were 110 participants in total. Accepted as a member of the MSDC 3 people.
Two clinical cases are presented in the clinical part of the meeting: widespread cutaneous leishmaniasis in an HIV-infected patient. The peculiarity of this clinical case was the extreme prevalence of rashes. No systemic pathology was detected; panniculitis in a patient after a COVID-19 infection. The process proceeded according to the type of non-stagnant Weber-Christian panniculitis: after surgical autopsy, a mucus-like substance was released.
Three reports were presented in the scientific part of the meeting. Corresponding member Prof. O.Y. Olisova (Sechenov University) made a report on the benefits of treating severe and moderate psoriasis with netakimab; researcher of State Scientific Center of Dermatovenereology and Cosmetology Central Dermatology and Venereology Institute A.A. Vorontsova reported on the results of an original study of the generality of clinical and pathomorphological manifestations of psoriasis and T-cell lymphoma; with pathogenetic justification of the development of cutaneous toxicity as a result of targeted therapy of oncological diseases was performed by E.V. Orlova (Sechenov University): it is based on the suppression and dysfunction of EGFR-controlled processes in the skin.
Missed Monteggia fractures in children – the current state of the problem: A systematic review
Authors: Gubaeva Aigul R. , Zorin Vyacheslav I.
Published: April 2023

BACKGROUNG: A situation in which despite an obvious ulnar fracture, radial head dislocation is not diagnosed, resulting in a missed Monteggia fracture is not uncommon. Unsatisfactory results of the treatment of this pathology have prompted several researchers to search for an optimal treatment strategy.
AIM: This study aimed to conduct a systematic review of literature data on missed Monteggia fractures and dislocations in children by studying the main therapeutic and tactical approaches to this problem.
MATERIALS AND METHODS: A literature search was conducted in the Cochrane Database, Science Direct, Google Scholar, PubMed, and eLibrary information bases, and the search depth was 10 years. Moreover, 46 sources were selected based on the criteria. The main characteristics revealing the problem were identified, divided into four semantic groups, according to which the literature was analyzed: initial data on the condition of patients at the time of seeking medical help, status before and after treatment, and treatment methods.
RESULTS: The average age of the children was 8.4 years. The average interval from injury to the surgical treatment of missed Monteggia fracture was 15.3 months, and 883 clinical cases presented in sources with known treatment techniques were analyzed. Thus, open reduction of the radial head in combination with the restoration or reconstruction of the annular ligament and ulnar osteotomy is one of the most common methods (n = 482, 54.6%). The second most frequent application was the above-described approach, but without manipulations on the annular ligament (n = 273, 30.9%). Bone osteosynthesis and external fixation apparatus were the most widely used stabilization methods in 350 (67.8%) and 149 (28.9%), respectively. The most common complications were associated with the deterioration of the functional status after surgery.
CONCLUSIONS: Accurate diagnosis of injury and early correction of existing disorders is the key to reducing the frequency of missed Monteggia fractures. Surgical treatment is the main method of treating children with this injury, in which the restoration of the ulnar anatomy and the ratios in the brachial and proximal radiocarpal joints are the most important, providing a more physiological development of the segment with the growth of the child.
Anti-Ukrainian narratives of Russia in the global information space
Authors: Shevchenko Olena , Yalovets Anatoliy
Published: April 2023

The article examines the anti-Ukrainian narratives that russian propaganda produces and spreads to various target audiences, in particular, to the Ukrainian and russian populations and citizens of Western countries. It is shown that the goals of russian propaganda differ depending on the audience, in particular, for Ukraine's foreign partners, russian narratives justify the need to seize Crimea, the importance of russian patronage over Ukraine, and the legitimacy of the separation of part of the East. For the russian domestic consumer, the purpose of narratives is to shift attention from internal problems to external factors; to explain the need for russian support of the self-proclaimed "republics" as part of the "russian peace" and to show that putin's regime has no alternative. For the Ukrainian population, it is to show the inability of the authorities to solve the internal problems of the state, the fallacy of the chosen path of European integration, and the inability of the leadership of Ukraine to carry out reforms. The authors also showed how russian propaganda messages evolved in the russian information space, as well as how the information space of Ukraine changed after the start of the full-scale invasion. A conclusion is made about the informational resistance of Ukrainian society in relation to russian narratives after the start of a full-scale invasion.
Memory wars, or the return of history. Book review Constructing Memory: Central and Eastern Europe in the New Geopolitical Reality, ed. Anna Bazhenova, Lublin: Instytut Europy Środkowej, 2022, 264 p.
Authors: Werner Wiktor
Published: April 2023

Memory wars, or the return of history. Book review Constructing Memory: Central and Eastern Europe in the New Geopolitical Reality, ed. Anna Bazhenova, Lublin: Instytut Europy Środkowej, 2022, 264 p.
Yeni Bir Tür Tanımı ile Türkiye’deki Mesiotelus Simon, 1897 Cinsine Katkılar (Araneae: Liocranidae)
Authors: DEMİRCAN AKSAN Nurcan
Published: April 2023

Bu çalışmada Mesiotelus Simon, 1897 cinsinin yeni türü, Mesiotelus mersinensis sp. n., Akdeniz Bölgesi'nden (Mersin) bir erkek üzerinden tanımlandı. Karakteristik yapıların çizimleri ve fotoğrafları sunuldu. Ayrıca, Türkiye’de oldukça zayıf bir dağılıma sahip olan bu cinsin Mesiotelus scopensis Drensky, 1935 türü, farklı bir lokaliteden kaydedildi. Türlerin Türkiye’deki mevcut dağılımı harita üzerinde gösterildi.
Laser transfer for circulating tumor cell isolation in liquid biopsy
Authors: Molpeceres Carlos , Ramos-Medina Rocio , Marquez Andres , Romero Paula , Gomez-Fontela Miguel , Candorcio-Simon Rocío , Muñoz Andres , Lauzurica Sara , Monte-Millan Maria del , Morales Miguel , Muñoz-Martin David , Lopez-Tarruella Sara , Massarrah Tatiana , Martin Miguel
Published: April 2023

Cancer research has found in the recent years a formidable ally in liquid biopsy, a noninvasive technique that allows the study of circulating tumor cells (CTCs) and biomolecules involved in the dynamics of cancer spread like cell-free nucleid acids or tumor-derived extracellular vesicles. However, single-cell isolation of CTCs with high viability for further genetic, phenotypic, and morphological characterization remains a challenge. We present a new approach for single CTC isolation in enriched blood samples using a liquid laser transfer (LLT) process, adapted from standard laser direct write techniques. In order to completely preserve the cells from direct laser irradiation, we used an ultraviolet laser to produce a blister-actuated laser-induced forward transfer process (BA-LIFT). Using a plasma-treated polyimide layer for blister generation, we completely shield the sample from the incident laser beam. The optical transparency of the polyimide allows direct cell targeting using a simplified optical setup, in which the laser irradiation module, standard imaging, and fluorescence imaging share a common optical path. Peripheral blood mononuclear cells (PBMCs) were identified by fluorescent markers, while target cancer cells remained unstained. As a proof of concept, we were able to isolate single MDA-MB-231 cancer cells using this negative selection process. Unstained target cells were isolated and culture while their DNA was sent for single-cell sequencing (SCS). Our approach appears to be an effective approach to isolate single CTCs, preserving cell characteristics in terms of cell viability and potential for further SCS.
Using 3D-bioprinted models to study pediatric neural crest-derived tumors
Authors: H. Quinn Colin , M. Beierle Andee , R. Julson Janet , E. Erwin Michael , Alrefai Hasan , R. Markert Hooper , E. Stewart Jerry , Hutchins Sara Claire , V. Bownes Laura , M. Aye Jamie , Mroczek-Musulman Elizabeth , H. Hicks Patricia , J. Yoon Karina , D. Willey Christopher , A. Beierle Elizabeth
Published: April 2023

The use of three-dimensional (3D) bioprinting has remained at the forefront of tissue engineering and has recently been employed for generating bioprinted solid tumors to be used as cancer models to test therapeutics. In pediatrics, neural crest-derived tumors are the most common type of extracranial solid tumors. There are only a few tumor-specific therapies that directly target these tumors, and the lack of new therapies remains detrimental to improving the outcomes for these patients. The absence of more efficacious therapies for pediatric solid tumors, in general, may be due to the inability of the currently employed preclinical models to recapitulate the solid tumor phenotype. In this study, we utilized 3D bioprinting to generate neural crest-derived solid tumors. The bioprinted tumors consisted of cells from established cell lines and patient-derived xenograft tumors mixed with a 6% gelatin/1% sodium alginate bioink. The viability and morphology of the bioprints were analyzed via bioluminescence and immunohisto chemistry, respectively. We compared the bioprints to traditional twodimensional (2D) cell culture under conditions such as hypoxia and therapeutics. We successfully produced viable neural crest-derived tumors that retained the histology and immunostaining characteristics of the original parent tumors. The bioprinted tumors propagated in culture and grew in orthotopic murine models. Furthermore, compared to cells grown in traditional 2D culture, the bioprinted tumors were resistant to hypoxia and chemotherapeutics, suggesting that the bioprints exhibited a phenotype that is consistent with that seen clinically in solid tumors, thus potentially making this model superior to traditional 2D culture for preclinical investigations. Future applications of this technology entail the potential to rapidly print pediatric solid tumors for use in highthroughput drug studies, expediting the identification of novel, individualized therapies.
Metrological characterization of porosity graded β-Ti21S triply periodic minimal surface cellular structure manufactured by laser powder bed fusion
Authors: Emanuelli Lorena , Biasi Raffaele De , Plessis Anton du , Lora Carlo , Jam Alireza , Benedetti Matteo , Pellizzari Massimo
Published: April 2023

The design of a functionally graded porous structure (FGPS) for use in prosthetic devices is crucial for meeting both mechanical and biological requirements. One of the most commonly used cellular structures in FGPS is the triply periodic minimal surface (TPMS) structure due to its ability to be defined by implicit equations, which allows for smooth transitions between layers. This study evaluates the feasibility of using a novel β-Ti21S alloy to fabricate TPMS-based FGPS. This beta titanium alloy exhibits low elastic modulus (53 GPa) and good mechanical properties in as-built condition. Two TPMS FGPSs with relative density gradients of 0.17, 0.34, 0.50, 0.66, and 0.83 and unit cell sizes of 2.5 mm and 4 mm were designed and fabricated using laser powder bed fusion (LPBF). The as-manufactured structures were analyzed using scanning electron microscopy (SEM) and X-ray micro-computed tomography (µ-CT), and the results were compared to the design. The analysis revealed that the pore size and ligament thickness were undersized by less than 5%. Compression tests showed that the stabilized elastic modulus was 4.1 GPa for the TPMS with a 2.5 mm unit cell size and 10.7 GPa for the TPMS with a 4 mm unit cell size. A finite element simulation was performed to predict the specimen’s elastic properties, and a lumped model based on lattice homogenized properties was proposed and its limitations were explored.
CLUB MODEL TO DEVELOP LIFE ADAPTIVE COMPETENCY FOR STUDENTS WITH DISABILITIES IN INCLUSIVE ELEMENTARY SCHOOLS
Authors: Nguyen Ha My , Tran Thi Bich Ngoc , Nguyen Minh Phuong
Published: April 2023

The issue of developing competencies for students with disabilities has been raising in recent years because of the issuance of a new program for all students from K1-12 - the 2018 General Education Program (GEP). Students with disabilities must face challenges to be able to develop their competencies in different subjects as well as in experiential activities. Life adaptive competency is one of very important competencies in the program of Experiential activities that students will develop their knowledge of understanding about themselves and their living environment as well as practice their self-regulation skills in responding to change. However, students with disabilities show a lack of life-adaptive competency because of the difficulties caused by their own disabilities as well as other external influences. The club model is one of the solutions that inclusive elementary schools can choose to improve competencies in general and life adaptive competency in particular for all students including those one with disabilities. This study focuses on finding out information about different club models and mentions 04 forms of club models as well as their meanings for students with disabilities so that they may have improved their life adaptive competency in inclusive elementary schools.