bluuebunny/crossref_metadata_2025 huggingface dataset:
Nickel Price Projection Using Multivariate Regression Method and Investment Feasibility Analysis of Nickel Mining in Indonesia with Sensitivity Analysis and Monte Carlo
Authors:   School of Business and Management, Institut Teknologi Bandung, R.M. Muhammad Chandra
Published: March 2024

Nickel is one of the metals commonly used in various industries. Indonesia is one of the countries that has the largest nickel reserves in the world. Nickel prices will be formed through an equilibrium mechanism between production supply and nickel demand. This study will analyse the relationship between nickel price formation, supply, and demand. Nickel prices will also affect the feasibility of nickel mining investment in Indonesia. The data used in this study consists of market data derived from historical reports of the last 5 – 12 years (2010 – 2022) and mining plan assumptions derived from benchmarks with similar industries. The methods used in this analysis are multivariate regression, discounted cash flow, sensitivity analysis, and Monte Carlo simulation. The results of the analysis that have been carried out show the relationship between nickel supply and demand with prices, with estimated nickel price projection ranging from $16,750 / Ton – to $18,927 / Ton. The factors that most influence the feasibility of mining investment are nickel price, sales realization, water content, contractor costs, and fuel costs. The risk of nickel mining investment in Indonesia based on Monte Carlo simulations is estimated at around 11.36%. This shows that nickel mining investment in Indonesia is still very attractive.
Efforts to Enhance Service Quality: The Roles of Innovation Capability and Service Recovery
Authors:   Universitas Sari Mutiara Indonesia, Medan, Indonesia, Sirait Ronnie Togar Mulia , Ginting Maretta ,   Universitas Sari Mutiara Indonesia, Medan, Indonesia, Maduwu Fridawati ,   Universitas Sari Mutiara Indonesia, Medan, Indonesia, Ndruru Martinus ,   Universitas Sari Mutiara Indonesia, Medan, Indonesia, Kalit Desi R.S. ,   Universitas Sari Mutiara Indonesia, Medan, Indonesia, Laia Adilman ,   Universitas Sari Mutiara Indonesia, Medan, Indonesia, Napitupulu Runggu Besmandala ,   Universitas Sari Mutiara Indonesia, Medan, Indonesia
Published: March 2024

This research aims to discuss the service quality issue at 4-star hotels in Medan. Next, build a model on how to enhance service quality. A sample of 560 guests was taken by random proportional from each hotel. Structural equation models with the lisrel software supported. Market orientation influences innovation capability and service quality. Value co-creation influences innovation capability, service recovery, and service quality. Innovation capability influences service recovery. Innovation capability mediation can increase the influence of market orientation on service recovery. Service recovery affects service quality. Integration between functions in hotels, especially information dissemination in formulating policies to increase innovation capabilities, is important to pay attention to. It is important to develop a risk-taking attitude to improve service recovery. Recovery strategies are important to pay attention to in efforts to improve service quality. The role of market orientation needs to be followed by innovation capability to improve service recovery.
Identification Test of Medicinal Chemicals (BKO) in Uric Acid Herbal Preparations Circulating in Bantaeng District Using the Densitometric KLT Method
Authors:   Pharmacognosy and Phytochemistry Division Faculty of Pharmacy, Universitas Muslim Indonesia-Makassar, Indonesia, Yusril M. , Handayani Virsa ,   Pharmacognosy and Phytochemistry Division Faculty of Pharmacy, Universitas Muslim Indonesia-Makassar, Indonesia, Handayani Selpida ,   Pharmacognosy and Phytochemistry Division Faculty of Pharmacy, Universitas Muslim Indonesia-Makassar, Indonesia
Published: March 2024

Medicinal Chemicals (BKO) in herbal medicine will be bad for health. Some of the BKOs commonly added to uric acid herbs such as piroxicam, piroxicam is a drug used for the treatment of gout. But the reality is that in the market there are still many that contain BKO. Added medicinal chemicals can have harmful side effects for consumers. In this study, the identification of piroxicam in uric acid herbal medicine has been carried out. Identification was carried out by preliminary tests in the form of organoleptic / macroscopic and microscopic tests. Qualitative test in the form of thin layer chromatography (KLT), and quantitative test in the form of densitometry. The organoleptic test results showed that the samples had powder and capsule dosage forms with dark ash, white, yellow and pale yellow colors. It has a bitter taste and aromatic odor. Microscopic test results showed plant fragments from each ingredient contained in the composition of slimming herbs. In the KLT test with the mobile phase acetone: chlorophom: n-hexan (7: 2: 1) obtained the Rf value of piroxicam comparator which is 0.8. Analysis of the five samples showed the same Rf value as the piroxicam comparator. Densitometry test on the samples showed that samples 1, 2 and 4 were positive for piroxicam.
A Case Report on Transverse Myelitis
Authors:   Pharm.D., Department of Pharm D, CMR College of Pharmacy, Hyderabad, Telangana, India, Dhomakonda Bhavani , Srujana Rayeni ,   Pharm.D., Department of Pharm D, CMR College of Pharmacy, Hyderabad, Telangana, India, Maiti Soumitra ,   Pharm.D., Department of Pharm D, CMR College of Pharmacy, Hyderabad, Telangana, India, Reddy Y. Vidhya ,   Pharm.D., Department of Pharm D, CMR College of Pharmacy, Hyderabad, Telangana, India, Rama Rao Tadikonda ,   Ph.D., Principal and Professor, CMR College of Pharmacy, Hyderabad, Telangana, India
Published: March 2024

Scrub typhus is known to cause central nervous system involvement, which can show as meningitis or meningoencephalitis. However, relatively few reports of acute transverse myelitis (ATM), a spinal cord lesion, have been linked to scrub typhus. Patients with a spinal lesion and scrub typhus have neurologic symptoms such as dysuria and sensory and motor impairment. Here, we report on an uncommon instance of ATM linked to scrub typhus. The diagnosis of ATM linked with scrub typhus was made based on the patient’s clinical features, cerebral fluid cytology, Orientia tsutsugamushi serum antibody titer, and several magnetic resonance imaging scans.
Voter Apathy in Nigerian Electoral Democracy: An Insidious Enigma to National Development
Authors:   Department of Public Administration, Federal University Otuoke, Bayelsa State, Nigeria, Temple C Nwambuko, , Chukwunenye C Njoku, ,   Department of Political Science, Alex Ekwueme Federal University, Ndufu Alaike Ikwo, Ebonyi State, Nigeria, Funmilayo Omiunu, ,   Department of Public Administration, Federal University Otuoke, Bayelsa State, Nigeria
Published: March 2024

This paper examines voter apathy in Nigerian electoral democracy as an insidious enigma to national development, with an emphasis on the 2023 General Elections. Elections in democracies play a vital role in ensuring the representation of popular will and securing the legitimacy of the political system. However, in situations where voter apathy is pronounced in the electoral processes of democratic countries, national development in such countries is nearly defeated. Voter apathy remains an insidious enigma for national development, and Nigeria provides an example of such a country. What is the way out? To answer this question, the paper made use of the decision-making theory by Richard Synder as its theoretical framework, adopted a qualitative research design, relied on secondary sources of data, and analyzed the collected data using the qualitative content data analysis method. The findings of the study revealed the factors causing voters’ apathy in Nigerian electoral democracy and their consequences on the country’s national development. Recommendations were made based on the findings.
Exploring the Harmonization of Political and Administrative Set-Ups for Better Service Delivery in an Organization- Case Study IPAM, USL
Authors:   Administrative Staff Institute of Public Administration and Management, University of Sierra Leone, Bangura Emmanuel John , Bangura Fuhad Amed Mohamed ,   Research Teaching Assistant Institute of Public Administration and Management, University of Sierra Leone
Published: March 2024

This research study examines the harmonization of political and administrative setups for better service delivery in an organization. The study focuses on the Institute of Public Administration and Management at the University of Sierra Leone (IPAM USL) to investigate the process of harmonization within the institution. Through a qualitative research design including interviews, observations, and content analysis, the study seeks to analyze the implementation of the harmonization process and its effects on the performance and service delivery of the institute. Key findings will provide insight into the effectiveness of the harmonization process and important recommendations for further improvement in service delivery through the harmonization of political and administrative set-ups.
Factors Affecting Residential Satisfaction with Social Housing in Urban Areas: International Researches and Current Situation in Vietnam
Authors:   Student, Faculty of Real Estate and Resources Economics, National Economics University, Hanoi, Vietnam, Tam Luu Tran Minh , Ngoc Anh Nguyen Thi ,   Student, Faculty of Marketing, National Economics University, Hanoi, Vietnam, Anh Hoang Duc ,   Student, Institute of AEP, National Economics University, Hanoi, Vietnam, Quynh Anh Le Thi ,   Student, Institute of AEP, National Economics University, Hanoi, Vietnam
Published: March 2024

This paper explores the multifaceted aspects contributing to residents' satisfaction within social housing in urban areas, integrating international research findings with Vietnam's current situation. It examines factors such as housing unit physical attributes, quality of infrastructure, service accessibility, community cohesion, and alignment with residents' expectations. By identifying gaps between expectations and experiences, the study proposes strategic interventions to enhance livability, sustainability, and satisfaction in social housing projects, offering insights relevant to Vietnam and other countries facing similar urban housing challenges.
Development, Delivery, and Evaluation of Mental and Emotional Well-Being of College Health Education for Physical Education Students
Authors:   Emilio Aguinaldo College, Manila, Philippines, Yangqiong Xiao
Published: March 2024

The study examines the mental and emotional well-being of physical education students at Guangdong Vocational College of Posts and Telecommunications. The research uses a descriptive-comparative design and three questionnaires. The majority of students are 17 years old or more, with a higher percentage of females. The study found no significant difference in student respondents' assessments of how their teachers deliver the comprehensive college health education program in terms of mental and emotional well-being. However, there was a significant difference in assessment when considering the course, with students pursuing education having a higher mean score and liberal arts students having a lower mean score. Teacher respondents, all full-pledge master's degree holders, had a high mean of 3.60 in terms of mental well-being, indicating that students have learned essential skills through self-reflection and emotional expression. Both male and female teachers have the same evaluation of their students' mental and emotional well-being in relation to the comprehensive college health education program.
A Study on the Terrorist State and the Terrorist Movements: A Case Study of Egypt
Authors:   Candidate at Centre for Islamic Studies and Civilisation, Charles Sturt University, Sydney, NSW 2144, AUSTRALIA., M.A., (Ph. D.) Omar Gomaa
Published: March 2024

Researchers have consistently delved into the study of terrorist movements within societies and states, yet few have explored the primary instigators behind their emergence, which is the focus of this research: the State. This study examines the emergence of the most influential terrorist movements, their treatment, and their relationship with the state. By scrutinising the reasons behind the emergence of terrorist movements, this research also discusses strategies to prevent and dismantle them. A critical aspect to note is that many terrorist movements originated within state prisons, underscoring the state's failure to prevent terrorism and inadvertently contributing to its proliferation within society. Understanding these dynamics is crucial for developing effective counterterrorism policies and addressing the root causes of terrorism. It also highlights techniques such as decapitation and negotiation, as well as providing emancipation for moderate Islamic movements to play a role and represent the image of Islam. Additionally, terrorist movements often promote their ideology through emotional propaganda to recruit Islamic youths, many of whom come from moderate Islamic movements like the Muslim Brotherhood.
Commodification of Workers in Tempo Magazine
Authors:   Syarif Hidayatullah State Islamic University, Jakarta, Indonesia, Amallah Nurlaillah Sari , Heryanto Gun Gun ,   Syarif Hidayatullah State Islamic University, Jakarta, Indonesia, Adeni Adeni ,   Walisongo State Islamic University, Semarang, Indonesia
Published: March 2024

Tempo Magazine commodifies workers through increased working hours, low wages, multiple tasks, and marketing promotions that become exchange value for the public. This research aims to reveal the commodification of workers in Tempo Magazine and fill the unique gaps in previous research. The paradigm used is critical because the researcher wants to show that Tempo Magazine journalists are considered commodities measured based on economic factors. Journalists are willing to exchange their labor and even spend time on holidays to meet sources for low wages. The data collection technique is carried out through observation; namely, the researcher observes the research object by classifying and combining articles in Tempo Magazine. Researchers also interviewed the Editor-in-Chief of Tempo Magazine, Tempo Magazine journalists, and eight former Tempo Magazine journalists as critical informants to see different sides of Tempo. The research results show that Tempo Magazine journalists do not apply a specific working time pattern when covering an issue. It is not uncommon for them to use their holiday time to meet sources. They are trapped in false consciousness and do not understand their exploitation by assuming that when they succeed in getting a source, it is a matter of prestige and will always be remembered. They also work more than regular hours but do not receive overtime pay or other compensation. In addition, photo works produced by journalists do not receive copyright protection. Tempo sold it without permission, and this is a copyright issue and protection of intellectual property rights in the media industry. The use or sale of images without permission can harm the creator financially and violate rights that should be protected. Journalists, as a profession that focuses on providing information, often support the human rights of others. However, they also face challenges and risks related to their human rights in their duties. Thus, this study confirms that worker commodification is for workers who are re-produced or renewed through exploitation processes such as increasing working time or intensifying the work process.
Implementasi Kegiatan Projek Penguatan Profil Pelajar Pancasila (P5) dalam Kurikulum Merdeka di Sekolah Dasar
Authors: Christiananda FR. , Purwaningrum Nova Sugiana , Rofisian Nela
Published: March 2024

Learning activities in elementary schools that have implemented the Independent Curriculum have problems regarding the implementation of P5 activities. One of them is that the teacher still does not understand the concepts used in P5 activities. Teachers only emphasize the results of projects made by students without paying attention to the project creation process. So students cannot develop their creativity according to their interests and talents. The aim of this research is to find out how to implement P5 activities at the elementary school level with differentiated learning. The method we use in this research is qualitative with a library research approach using literature study. The objects of this research are students and educators at elementary school level who have used the Independent Curriculum. The research results show that P5 learning must use differentiated learning with 8 stages and choose several scheduling options.
Pengenalan Konsep Dasar Dan Penggunaan Database Manajemen Sistem (DBMS)
Authors: Sabbrina Aura , Sufa Amanda oktavia , Ritonga Dendi putra , Siregar Efrida Rahma sari , . Nurbaiti
Published: March 2024

Penelitian ini bertujuan ini adalah untuk memperkenalkan konsep dasar database manajemen sistem yang dapat diterapkan sistem database manajemen pada setiap organisasi atau perusahaan maka perlu mengenal terlebih dahulu apa itu database manajemen sistem, bagaimana peranan database manajemen sistem, dan bagaimana struktur DBMS serta penerapan DBMS. Didalam dunia usaha, dunia pendidikan dan dunia kerja. Informasi adalah bagian penting sebagai informasi akurat dan tepat waktu akan membantu manajer dalam mengambil keputusan untuk mempertahankan dan mengembangkan organisasi dan usahanya. Maka dari itu diperlukannya suatu sistem database yang lengkap, akurat, dan dapat ditampilkan secara cepat dan mudah setiap diperlukan. Pada database terdapat sebuah perangkat lunak yang memudahkan pengguna basis data (database user) untuk memelihara, mengontrol, dan mengakses data dengan praktis dan efesien yaitu disebut Database Manajemen Sistem (DBMS). Oleh karena itu peranan database manajemen sistem sudah diterapkan dalam pengelolaan data pegawai, data Pendidikan (siswa), data mahasiswa, data karyawan,dll. Penulis menggunakan metode kualitatif dengan pendekatan deskriptif yaitu library research yang akan mengupas database manajemen sistem dari beberapa infromasi sedalam dalamnya yang didapat dari sumber data pustaka buku, artikel, dan sumber Pustaka lainnya. Hasil penelitian ini akan menunjukan bahwa konsep dasar database manajemen sistem, manfaat DBMS, Peranan DBMS, skema yang dibuat DBMS, Struktur DBMS, dan Mengetahui mendiskripsikan dan menyimpan data dalam DBMS dengan model data relasional DBMS, dan aplikasi DBMS pada kemahasiswaan Universitas islam negeri sumatera utara
Metabolic Syndrome in Obese Children and Adolescents
Authors:   University Hospital Center Mustapha Algiers, Algeria, Cherfaoui Assia , Hadji Amel ,   University Hospital Center Mustapha Algiers, Algeria, Boukari Rachida ,   University Hospital Center Mustapha Algiers, Algeria
Published: March 2024

Introduction: Metabolic syndrome is one of the complications of obesity with a significant impact on health. This MS is diagnosed according to the International Diabetes Federation 2007 in children aged 10 to 16 years with waist circumference > 90th percentile according to the curves of McCarthy and two of the following metabolic characteristics: HDL C < 40 mg/dL, TG≥150 mg/dL, blood glucose ≥ 100 mg/dL and blood pressure≥130/85mmHg. Goals: We performed a retrospective and prospective study at the pediatric obesity consultation. The main objective is to assess the metabolic syndrome in a population of obese children and dolescents. The secondary objectives are the evaluation of the various criteria of the metabolic syndrome, and the impact of the degree of obesity, the search for comorbidities and their repercussions, and finally the evaluation of the care.
Analisis Biaya Ekonomi Serta Dampak Lingkungan Penggunaan Gasoline dan Biofuel Sebagai Bahan Bakar Transportasi
Authors: Dinanti Prisila , Sundari Sri , Laksmono Rudy , Ramadhan Try Ridho , Sianipar Leo
Published: March 2024

Global warming is not the newest issue we are facing. Until now, the issue of global warming is still a topic of discussion among world-class researchers. Global warming is the increase in the earth's temperature or the average temperature of the atmosphere, sea and earth's land that we are experiencing today. The amount of carbon obtained at this time is the result of industrial, transportation, household and commercial activities in the use of energy consumption. In order to suppress rising temperatures, the government has made the decision to continue its commitment to reducing greenhouse gas emissions by taking a number of strategic steps in the management of the energy, transportation and energy sectors. The government's strategy in the transportation sector is to transition oil-fueled vehicles into electric motorized vehicles. The strategic step to reduce fossil energy consumption is to increase the production of environmentally friendly energy such as bioethanol. However, mixing bioethanol as an environmentally friendly alternative fuel faces problems. Related to the obstacles that become obstacles due to the relatively high cost of bioethanol production, resistance from local entrepreneurs, and limited supply. This writing is by applying the Literature Review method. Literature review contains descriptions of theories, findings and other research materials derived from reference materials as the basis for research activities. In terms of economic and environmental aspects, the use of bioethanol in vehicle fuel can be an alternative solution that must be continuously developed and produced.

Keywords: Biofuels, Economic Costs, Gasoline, GHG Emissions, Environment.
Valvuloplastía aórtica bajo guía ecocardiográfica en un lactante menor en un centro de referencia nacional del Perú: reporte de caso
Authors: Catalán Cabrera Alex , Condori Alvino Karen
Published: March 2024

Aortic stenosis is a congenital heart defect that causes a fixed left ventricular outflow obstruction with a progressive course. Symptomatology in neonates and young infants resembles congestive heart failure. In addition, the diagnosis of this condition is made by imaging, through echocardiography. On the other hand, treatment can be surgical or interventional under fluoroscopic guidance, depending on the hospital in which it is performed. We describe the case of a minor infant patient who presented severe aortic valve stenosis; however, the fluoroscopy equipment was not available at the time of the emergency to perform the appropriate procedure, therefore, an aortic valvuloplasty was performed under echocardiographic guidance without complications.
THE EFFECT OF INTERNAL BUSINESS COMMUNICATION ON THE CORPORATE IMAGE
Authors:   Department of International Business, Faculty of Economic Sciences,  University of Oradea, Oradea, Romania, POP Anamaria-Mirabela , SIM Monica-Ariana ,   Department of International Business, Faculty of Economic Sciences,  University of Oradea, Oradea, Romania
Published: March 2024

Since it is one of the most fundamental elements of establishing a relationship, effective communication is necessary in almost all professions. Business thrives on communication since it depends so heavily on relationships between diverse people. Any type of communication is always important to business. It increases a company’s efficacy and efficiency and keeps the appropriate ratio of different strategies for projecting the ideal image. The two types of communication in business are internal and external. Communication between two organizations, as well as between a company and its clients, is referred to as external communication. Information exchange within a company is referred to as internal communication. It happens amongst co-workers as well as between employers and employees. Internal communication is therefore essential for connecting with employees, running the business, and improving the company’s reputation. No matter how big or how profitable a business is, internal communication is crucial. It significantly affects an organisation’s success, since effectively articulated strategies help enhance employee productivity, employee engagement and team collaboration. The open and transparent environment created by the communication process helps employees comprehend the company’s objective and their individual role in achieving it. It guarantees excellent employee cooperation in achieving the shared objective. Good internal communication promotes exceptional staff engagement, which in turn increases corporate performance and ensures high levels of customer satisfaction. Internal corporate communication is essential for impacting daily operations, fostering cross-departmental relationships, and, most significantly, dismantling organizational silos. It aids in creating a united culture throughout the company to enable all employees to make the best judgments. Consequently, internal communication has an impact on a company’s productivity, profitability, and overall brand image. It also influences both bosses and employees’ morale. Thus, one must create a successful internal company communication plan to engage the workforce for greater production and pay attention to their worries and anxieties over their jobs. Therefore, the paper’s main goal is to analyze internal communication tasks while concentrating on how they affect various areas of business performance. The paper is based on a critical analysis of the relevant literature, taking into account works that address the problem’s practical aspect.
DIFFICULTIES IN TEACHING GERMAN MODAL VERBS TO ECONOMICS STUDENTS
Authors:   Department of International Business, Faculty of Economic Sciences, Oradea, Romania, SĂCARA-ONIŢA Adina , PORUMB Andra-Teodora ,   Department of International Business, Faculty of Economic Sciences, Oradea, Romania
Published: March 2024

Modal verbs are an important chapter in learning German. The paper presents how the modal verbs are thought to the economics students in our university, emphasizing the common mistakes of the students and possible measures the teacher should take in order to diminish the number of learning mistakes. The first part of the paper deals with the theoretical background, thus being such a difficult subject for the Romanian student, the paper brings up even the conjunction differences on this subject, dealing with different verbal tenses in the German grammar. The second part of this paper presents a text full of modal verbs, in different tenses, the students are asked to recognize them. In the paper I will show the mistakes the students usually make and the proportion of the right answers at this task. The following part deals with different exercises, in order to conclude the mistakes and the proportion of the right answers at this challenge. The final part shows the conclusions of this study that reflects on the results of the conducted measurements. The modal verbs play an important role in facilitating an efficient and understandable communication pattern in the society and therefore, they form significant aspect in the human language. Modal verbs add to the text precision and clearance in its meaning.
DRIVERS OF DIGITAL TRANSFORMATION IN PRODUCT DEVELOPMENT, BUSINESS MODELING AND HUMAN RESOURCES MANAGEMENT
Authors:   Babeș-Bolyai University (Management, Faculty of Economics and Business Administration), Cluj-Napoca, Romania, PETRESCU Georgiana-Maria , ȘTEF Anda Larisa ,   Babeș-Bolyai University (Management, Faculty of Economics and Business Administration), Cluj-Napoca, Romania, CÎMPAN Ioana ,   Babeș-Bolyai University (Management, Faculty of Economics and Business Administration), Cluj-Napoca, Romania, CRIȘAN Emil Lucian ,   Babeș-Bolyai University (Management, Faculty of Economics and Business Administration), Cluj-Napoca, Romania, SALANȚĂ Irina Iulia ,   Babeș-Bolyai University (Management, Faculty of Economics and Business Administration), Cluj-Napoca, Romania,   Prodigy IT Solution SRL
Published: March 2024

Digital transformation profoundly affects the business world, with both positive and negative outcomes. The purpose of this paper is to analyze how three business areas have been affected by the digital transformation. Therefore, we analyze the digital transformation of product development, the human resources management process, and business models. The analysis provides information and knowledge to researchers who address technological development in their work. A literature review on the evolution of the three fields has been performed. The comparative analysis reveals the existence of three main drivers concerning DT adoption in the three fields: improving communication, costs reduction, and increasing efficiency. The findings are relevant both for the three domains analyzed and for future research on the development of digitalization in general.
English as a gatekeeper
Authors: Bergström Jenny
Published: March 2024

This paper investigates power structures in English-language education within Sweden's Language Introduction Program (LIP). In Swedish society, a high proficiency in English plays an important role in accessing further education and the job market. Inadequate proficiency in English can lead to inequality in education, and thus to inequality in society in a long-term perspective. The methodology of this study is based on linguistic ethnography using interview data from seven semi-structured individual interviews with principals, mentors, a student counselor, and a special-needs educator involved in LIP at a Swedish school. Foucauldian perspectives of power and Fairclough’s critical discourse analysis are used to examine power structures and language ideologies within the organization. The results show how LIP’s organizational structures disadvantage the international language of English. Furthermore, power structures of governmentality within the organization steer students towards vocational programs rather than of theoretical programs
Fenotipificación y genotipificación en pacientes con enfermedad inflamatoria intestinal en un centro de referencia de Colombia
Authors: Parra Izquierdo Viviana , Hani Albis Cecilia , Romero-Sánchez Consuelo , Sánchez Ana Isabel , Laguado Yuly , Leguizamó Ana María , Frías-Ordoñez Juan Sebastián , Puentes Gerardo Andrés , Zarante Ignacio
Published: March 2024

Introducción: Se ha tratado de identificar los factores genéticos relacionados con susceptibilidad para enfermedad inflamatoria intestinal (EII), y los hallazgos actuales se inclinan por un modelo de patología complejo, sin un patrón hereditario claro. Objetivo: Realizar caracterización fenotípica y genotípica de pacientes con EII en población colombiana y describir su posible asociación con predisposición. Materiales y métodos: Serie de casos, 16 pacientes con EII por criterios clínicos y anatomopatológicos, inicio de síntomas gastrointestinales después de los 18 años. Todos tuvieron asesoramiento genético pre-test y se realizaron árboles genealógicos de mínimo tres generaciones. También, genotipificación, por medio de un panel de genes múltiples que incluía genes relacionados con EII y algunos trastornos autoinmunitarios. Finalmente, se realizó análisis genómico de variantes. Resultados: 9 mujeres y 7 hombres, con edad media de diagnóstico de EII 35 años, y 32 años para aparición de síntomas gastrointestinales. 11/16(68,75%) requirieron terapia biológica. 10/16 (62,5%) presentaron refractariedad a terapia estándar. 3/16 (18,75%) tenían antecedentes familiares positivos de EII. 100% casos presentaron al menos un single nucleotide polymorphism relacionado con riesgo de EII en más de un gen. Los genes más relacionados con colitis ulcerosa (CU), fueron CD48, CD6, y TYK2 para CU, y CD6 e ITGAM para la enfermedad de Crohn. El gen más frecuente fue CD6. Se observó en 3/16 (18,75%) presencia de hasta 5 genes, 4 en 3/16 (18,75%), y tres en 5/16 (31,25%). Conclusión: En EII hay presencia de variantes genéticas con predisposición asociada, pero sin patogenicidad confirmada, y cuya sumatoria parece contribuir en su fisiopatología
Neural longitudinal mapping of multidimensional performance profiles of Latin American universities
Authors: Jiménez-Andrade Jose Luis , Martí-Lahera Yohannis , Carrillo Calvet Humberto
Published: March 2024

Objective. To introduce an artificial intelligence method and to use it to analyze the evolution of the multidimensional performance profiles of the most prominent Latin American universities, according to the Times Higher Education Latin America University Rankings.

 Design/Methodology/Approach. To multidimensionally characterize universities' performance profiles, we use the rankings' sub-scores indicators, which quantify five dimensions of academic endeavor assessed by this ranking. To automatically compare and visually analyze performance profile's evolution our method uses an artificial neural network.

Results/Discussion. The neurocomputational procedure allowed us to discover all the characteristic performance profiles of the 50 best ranked universities (20 institutional profiles in 2019), and to visualize, in a knowledge map, the universities' groups sharing similar profiles. Furthermore, the profile's evolution of this group of universities was analyzed, and visually displayed in a sequence of knowledge maps, covering the four years period 2016-2019. In general, these universities show a remarkable improvement in Teaching, Research and Citation scores during 2016-2019. The profiles diversity of the best ranked universities, and the predominance and homogenization process of Brazilian universities profiles are noteworthy.

Conclusions. Performance profile characterization using multiple indicators is a matter of interest in diverse domains. However, visualization or comparison of multidimensional performance profiles is not an easy task for the human mind. Even more challenging is the visual analysis of multidimensional performance profiles evolution. The neuro-longitudinal technique introduced is a useful tool to analyze and visualize the evolution of multidimensional performance profiles.

Originality/Value. The approach and techniques introduced in the paper have an important degree of generality and can be used to analyze other type of rankings or multidimensional data.
Antiaging Cream Formula From Lemongrass Leaf Extract (Chymbopogon Citratus)
Authors: Ramadhani Shafira , Nyoman Ehrich Lister I , Fachrial Edy , Hakim Nasution Ikhwanul
Published: March 2024

This study aimed to determine the formula of anti-aging cream using lemongrass leaf extract. The treatment by giving respondents lemongrass leaf extract and using moisture, evenness, pore, spot, and wrinkle as parameters. Human skin provides protection on the surface of the body against the influence of the surrounding environment. Skin can experience aging, especially in areas that are often exposed to direct sunlight such as the face, neck, upper arms, and hands. Aging is a process experienced by humans in their 30s whose functions in the human body are decreasing, for example, thinning skin, wrinkles, rough skin, and dark spots on the face. Treatment to prevent aging of the skin by using an antioxidant product such as flavonoids because it has the function of preventing or neutralizing free radicals. In Indonesia, several species of plants can be found that function as food and cosmetic ingredients. The lemongrass leaf extract which contains antiaging are Alkaloids, Flavonoids, and Tannins. The data were analysed by using the Kolmogorov-Smirnov method to determine homogeneity and normality. Then, if the data is normal, it is continued to be analysed using the One-Way ANOVA method to determine the average difference between groups. There is a difference between treatments, and it is continued with the Post-hoc Tukey HSD test. The higher the concentration of extract used, the greater the anti-aging productivity formed. It is concluded, the best anti-aging effect is a concentration of 9% with increase in moisture, evenness, pore reduction, reducing spots and wrinkles.
Verification of parameterizations for clear sky downwelling longwave irradiance in the Arctic
Authors: Pace Giandomenico , di Sarra Alcide , Cali Quaglia Filippo , Ciardini Virginia , Di Iorio Tatiana , Iaccarino Antonio , Meloni Daniela , Muscari Giovanni , Scarchilli Claudio
Published: March 2024

Abstract. Ground-based high resolution observations of downward longwave irradiance (DLI), surface air temperature, water vapor surface partial pressure and column amount, zenith sky infrared (IR) radiance in the atmospheric window, and all-sky camera images are regularly obtained at the Thule High Arctic Atmospheric Observatory (THAAO, 76.5° N, 68.8° W), northwestern Greenland. The datasets for the years 2017 and 2018 have been used to assess the performance of different empirical formulas used to infer clear sky DLI. An algorithm to identify clear sky observations has been developed, based on value, variability, and persistence of zenith sky IR radiance. Seventeen different formulas to estimate DLI have been tested against the THAAO dataset, using the originally determined coefficients. The formulas that combine information on total column water vapor and surface air temperature appear to perform better than others, with a mean bias with respect to the measured DLI smaller than 1 W m−2 and a root mean squared error (RMSE) around 6 W m−2. Unexpectedly, some formulas specifically developed for the Arctic are found to produce poor statistical results. This is attributed partly to limitations in the originally used dataset, which does not cover a whole year or is relative to very specific condition (i.e., the presence of an ice sheet). As expected, the bias displays a significant improvement when the coefficients of the different formulas are calculated using the THAAO dataset. The presence of 2 full years of data allows the determination and the applicability of the coefficients for singular years and the evaluation of results. The smallest values of the bias and RMSE reach 0.1 and 5 W m−2, respectively. Overall, the best results are found for formulas that use both surface parameters and total water vapor column content, and have been developed from global datasets. Conversely, formulas that express the atmospheric emissivity as a linear function of the logarithm of the column integrated water vapor appear to reproduce poorly the observations at THAAO.
Dynamic MJO forecasts using an ensemble subseasonal-to-seasonal forecast system of IAP-CAS model
Authors: Liu Yangke , Bao Qing , He Bian , Wu Xiaofei , Yang Jing , Liu Yimin , Wu Guoxiong , Zhu Tao , Zhou Siyuan , Tang Yao , Qu Ankang , Fan Yalan , Liu Anling , Chen Dandan , Luo Zhaoming , Hu Xing , Wu Tongwen
Published: March 2024

Abstract. The Madden-Julian Oscillation (MJO) is a crucial predictability source on a sub-seasonal to seasonal (S2S) timescale. Therefore, the models participating in the WWRP/WCRP S2S prediction project focus on accurately predicting and analyzing the MJO. This study provided a detailed description of the configuration within the IAP-CAS S2S forecast system. We assessed the accuracy of the IAP-CAS model's MJO forecast using traditional RMM analysis and cluster analysis. Then, we explained the reasons behind any bias observed in the MJO forecast. Comparing the 20-year hindcast with observations, we found that the IAP-CAS ensemble mean has a skill of 24 days. However, there is still room for improvement in the ensemble spread. To examine the MJO structure in detail, we used cluster analysis to classify the MJO events during boreal winter into four types: fast-propagating, slow-propagating, standing, and jumping patterns of MJO. The model exhibits biases of overestimated amplitude and faster propagation speed in the propagating MJO events. Upon further analysis, it was found that the model forecasted a wetter background state. This leads to more intense forecasted convection and stronger coupled winds, especially in the fast MJO events. However, the horizontal moisture advection effect for eastward propagation is overestimated in IAP-CAS due to the wetter state and more substantial MJO circulations, which results in a faster MJO mode. These findings show that the IAP-CAS skilfully forecasts signals of MJO and its propagation, and they also provide valuable guidance for improving the current MJO forecast by developing the ensemble system and moisture forecast.
Shipborne Comparison of Infrared and Passive Microwave Radiometers for Sea Surface Temperature Observations
Authors: Gacitúa Guisella , Høyer Jacob L. , Søbjærg Sten Schmidl , Shi Hoyeon , Skarpalezos Sotirios , Karagali Ioanna , Alerskans Emy , Donlon Craig
Published: March 2024

Abstract. In the spring of 2021, a shipborne comparison of sea surface temperature (SST) measurements was undertaken using Thermal Infrared (TIR) and Passive Microwave (PMW) radiometers. The Danish Meteorological Institute (DMI) and the Technical University of Denmark (DTU) jointly deployed two TIR and two PMW instruments aboard the Norröna ferry, which traversed between Denmark and Iceland for a week. The primary objective was to assess the proximity-based comparison of TIR and PMW measurements, minimizing atmospheric influences and providing valuable insights into skin (TIR) and sub-skin (PMW) SSTs. A linear regression algorithm was developed using TIR SST data as a reference to derive PMW SST from brightness temperature. The data analysis primarily focused on evaluating data variability, identifying discrepancies between TIR and PMW SST, and assessing the overall uncertainty in the retrieval process. The overall root mean squared error (RMSE) of the retrieved PMW SST was 0.88 K during the ship’s motion and 0.94 K under stable conditions when the ship was moored. The analysis of the retrieved SST error budget involved the consideration of observed quantities and a forward model, accounting for factors like instrument noise, wind speed, incident angles, and the RMSE of skin and sub-skin temperature. The resulting error budget indicated 0.97 K for the data acquired during motion and 0.34 K for data collected during port stay.
CAECENET: An automatic system processing photometer and ceilometer data from different networks to provide columnar and vertically-resolved aerosol properties
Authors: Herrero del Barrio Celia , Román Roberto , González Ramiro , Cazorla Alberto , Herreras-Giralda Marcos , Antuña-Sánchez Juan Carlos , Molero Francisco , Navas-Guzmán Francisco , Serrano Antonio , Obregón María Ángeles , Sola Yolanda , Pandolfi Marco , Herrero-Anta Sara , González-Fernández Daniel , Muñiz-Rosado Jorge , Mateos David , Calle Abel , Toledano Carlos , Cachorro Victoria Eugenia , de Frutos Ángel Máximo
Published: March 2024

Abstract. This work introduces CAECENET, a new system capable of automatically retrieving columnar and vertically-resolved aerosol properties running the GRASP (Generalized Retrieval of Atmosphere and Surface Properties) algorithm using sun-sky photometer (aerosol optical depth, AOD; and sky radiance measurements) and ceilometer (range corrected signal; RCS) data as input. This method, so called GRASPpac, is implemented in CAECENET, which assimilates sun-sky photometers data from CÆLIS database and ceilometer data from ICENET database (Iberian Ceilometer Network). CAECENET allows for continuous and near-real-time monitoring of both vertical and columnar aerosol properties. The main characteristics and workflow of CAECENET are explained in detail. This work also explores the potential of CAECENET to monitor and analyze the evolution of transported aerosol events on a regional scale by means of the distribution of CAECENET stations across the Iberian Peninsula. As an example, this paper analyzes, using the CAECENET products, the case of a Saharan dust outbreak that occurred between the 3rd and 5th of October 2022. This was an intense event, with AOD at 440 nm values around 0.5 in Madrid and Valladolid, and reaching 1.55 in Granada. Transport from the Canadian wildfires at the end of June 2023 is also studied. Despite the long-range transport of the smoke particles in this event, measured volume concentrations reached and surpassed 80 μm3/μm2 in some stations. The results obtained point to the utility of this CAECENET tool for analyzing changes in the height and speed of the event propagation, in the aerosol concentration, and how this affects the optical properties.
Optimizing WRF-Hydro Calibration in the Himalayan Basin: Precipitation Influence and Parameter Sensitivity Analysis
Authors: Dixit Ankur , Sahany Sandeep , Lehner Flavio , Mishra Saroj Kanta
Published: March 2024

Abstract. Lack of in-situ observations and reliable climate information in large part of the Himalayas poses a significant challenges for assessing water resources vulnerability accurately. Further, the reliance on only a few coarse resolution gridded datasets with considerable uncertainty complicates this problem. However, integrated hydrometeorological modeling systems, like WRF-Hydro, have the potential to provide information in such ungauged or poorly observed regions, yet they require careful calibration. Here, we calibrate and assess the fidelity of WRF-Hydro in simulating the hydrological regime of the Beas basin. Selected WRF-Hydro model parameters are calibrated using the PEST framework, using eight simulations with two meteorological forcings from two WRF realisations. Model calibration improves the accuracy of the basin discharge simulation, however the choice of precipitation forcing is also critically important. We propose an ensemble weighting scheme to optimize an intra-annual tradeoff between streamflow under- and overestimation in different WRF-Hydro configurations. This study demonstrate the efficacy of using coupled (offline) WRF and WRF-Hydro for providing climate change impact-relevant information in data-sparse basins.
A New Technique for Airborne Measurements to Quantify Methane Emissions Over a Wide Range: Implementation and Validation
Authors: Dooley Jonathan F. , Minschwaner Kenneth , Dubey Manvendra K. , El Abbadi Sahar H. , Sherwin Evan D. , Meyer Aaron G. , Follansbee Emily , Lee James E.
Published: March 2024

Abstract. Methane (CH4) is a powerful greenhouse gas with a global warming potential 84 times higher than carbon dioxide (CO2) over 20 years. CH4 is produced from many natural and anthropogenic sources which can be further classified as biogenic or thermogenic in origin. The largest biogenic sources result from anaerobic decay such as wetlands, melting permafrost, or the breakdown of organic matter in the guts of ruminant animals. Thermogenic CH4 is generated during the breakdown of organic matter at high temperatures and pressure within the Earth's crust, a process which also produces more complex trace hydrocarbons such as ethane (C2H6) and propane (C3H8). Emissions of thermogenic CH4 are dominated by the fossil fuel energy sector, and the presence of elevated C2H6 along with CH4 can be used to distinguish oil and gas emissions from biogenic sources. This work outlines the development and deployment of an Unmanned Aerial System (UAS) outfitted with a fast (1 Hz) and sensitive (1–2 ppb s-1) CH4 & C2H6 sensor and ultrasonic anemometer. The UAV platform is a vertical-takeoff, hexarotor vehicle capable of vertical profiling to 120 m altitude and plume sampling across scales up to 1 km. This system has been used for direct quantification of point sources, as well as distributed emitters such as landfills, with source rates as low as 0.04 kg h-1 and up to 1500 kg h-1. Simultaneous measurements of CH4 and C2H6 mixing ratios, vector winds, and positional data allows for source classification (biogenic versus thermogenic), differentiation, and emission rates without the need for modeling or a priori assumptions about winds, vertical mixing, or other environmental conditions. The UAS has been deployed throughout the Southwest United States for system validation and targeted quantification of various sources emitting at or below the detection limits of other aircraft and satellite systems. This system offers a direct, repeatable method of horizontal and vertical profiling of emission plumes at scales that provide complementary information for regional aerial surveys as well as local ground-based monitoring.