bluuebunny/crossref_metadata_2025 huggingface dataset:
THE PRODUCTION OF SCALAR UNPARTICLE IN PAIR WITH PHOTON AND Z BOSON FROM + −  COLLISION IN UNPARTICLE PHYSICS
Authors: Le Nhu Thuc , Dao Thi Le Thuy
Published: October 2021

This work aims to calculate the scalar unparticle ( ) U0 production in pair with photon and Z boson at + −  collision in unparticle physics perspective. The work shows that + −  collision process involving scalar unparticles with dimension 2 dU  via the photon or Z boson exchange has been only done for schannel while via muon ( ) − exchange it has been done for t and u-channel. The cross-sections of the production of U0 in the   + − collider when the   + − , beams are unpolarized in unparticle physics were calculated in detail. The obvious dependence of differential cross-section (DCS) on the scattering angle ( )  and the cross-section (CS) on the center of mass-energy ( ) s which is the available range of energy at the future high energy frontier muon collider in the Muon Accelerator Program (MAP) were evaluated respectively.
Develop the capacity to apply knowledge, skill learned for students through experience teaching in Natural and Social subjects
Authors: Tran Thi Kim Cuc
Published: October 2021

The Natural and Social Subject General Education Program aims to build and develop scientific capacity for students. In order to acquire this capacity, under the guidance of teachers, students are allowed to work on the formation of competencies from the capacity of scientific awareness, the capacity to understand the surrounding natural and social environment to the capacity to apply knowledge, skills learned. With the capacity to apply the knowledge and skills learned, teachers need to create opportunities for students to work to acquire knowledge and skills to build their own capacity through experiential teaching. This article deals with developing the capacity to apply the knowledge and skills learned to students through teaching Nature and Society experience in elementary schools to meet the current educational innovation requirements.
The status of final year pre-service teachers’ teaching competence of some teacher education universities: Result of pre-service teachers self-assessment
Authors: Nguyen Thu Trang
Published: October 2021

Teaching competency is an important component of the professional competencies of teacher training curriculum. This article analyzes the results of final year pre-service teachers self-assessment on their teaching competence and difficulties in developing it. Participants were 316 fourth-year preservice teachers of three major pedagogical universities in Vietnam: Hanoi National University of Education, The University of Danang - University of Education, Ho Chi Minh City University of Education. The results show that final year preservice teachers selfassess their teaching competence at a good level; in which there are some components that are not good and have many difficulties to develop such as: Supporting students with special needs in learning; Differentiated teaching; Selecting and using teaching methods, facilities and forms of teaching organization. The results of this study are expected useful for developing teaching competence of preservice teachers and aiming to diversify assessment methods in education and training, including learners' self-assessment, contributing to improving the effectiveness of teacher training.
Applying "assessment for learning" strategies in teaching mathematics education courses at pedagogical universities
Authors: Nguyen Phuong Chi
Published: October 2021

Assessment for learning is the assessment that the first priority is to improve students' learning. It is the process of exploring and explaining the evidence for use by learners and teachers to determine where the learners are in their learning, where they need to go, and how best to get there. To adapt to the innovations of assessments in teaching school mathematics, the purpose of "assessment for learning" needs to be considered in educational courses in pedagogical universities, especially in teaching "mathematics education courses." This paper makes clear what "assessment for learning" is, proposes the process of designing and organizing assessment activities for teacher students, and applies "assessment for learning" strategies in teaching "mathematics education courses."
Pharmacological investigations of neuroprotective potential of Centella lujica supplement on sleep deprivation-induced anxiety-like behaviour in mice
Authors: Eduviere Anthony T. , Awhin Prosper E. , Edje Kesiena E. , Otomewo Lily O. , Moke Emuesiri G. , Omogbiya Adrian I. , Idiowa Oghenemaro P.
Published: October 2021

Background: Sleep deprivation has often been implicated in several neurological disorders. Centella lujica is a psychoactive herb with medically-beneficial therapeutic potential. The current study sought to evaluate the neuroprotective effect of Centella lujica supplement in experimental animals.Methods: Sleep deprivation in mice was done using the multiple platforms over water model.Results: Upon treatment with Centella lujica supplement, the parameters of anxiety-like behaviour induced by sleep deprivation were found to be significantly diminished in comparison to the sleep deprived animals.Conclusions: Centella lujica treatment significantly decreased hyper locomotion, and anxiety-like behaviour caused by sleep deprivation.
Consumer focused education on acetaminophen side effects, inadequate outcomes and weaning for individuals with low back pain: protocol for a feasibility study
Authors: Patterson Thomas , Turner Justin Turner , Gnjidic Danijela , Mintzes Barbara , Baysari Melissa , Bennett Carol , Bywaters Lisa , Clavisi Ornella , Ferreira Manuela , Beckenkamp Paula , Ferreira Paulo
Published: October 2021

Background: Prescription and over the counter medications, such as paracetamol, account for a significant proportion of the direct and indirect costs in managing low back pain (LBP). Existing research has not only questioned the efficacy of paracetamol use for musculoskeletal conditions such as LBP, but also its safety. No previous study has investigated the feasibility of a pharmacological education tool for individuals using paracetamol to manage their LBP. The aims of this study are to investigate: (1) the acceptability and experience of participants with the pharmacological education tool, (2) feasibility of recruitment, data collection and outcome measure completion, and (3) participant’s willingness to participate in a randomised control trial.

Methods: This will be a single group repeated measures study design recruiting individuals from community organisations. Included participants will be over 18 years, experiencing acute, chronic or recurrent episodes of LBP and self-report consumption of paracetamol for pain relief weekly for at least one month. This study will be open for recruitment from June 2021 to August 2021.

Conclusions: Our findings will inform the feasibility of conducting a larger randomised controlled trial. This study will be judged as feasible to proceed to a full trial based if, 1) recruitment sources are each able to enrol at least 20 participants into the study within three months of initial advertisement, 2) the majority of participants find the study and intervention experience as acceptable, and 3) there is less than 20% of missing data for the primary outcomes, and a minimum of 85% follow-up rate for enrolled participants.
Effect of active warming during general anaesthesia on post-operative body temperature, shivering, thermal comfort, pain, nausea and vomiting in adult patients: a randomized clinical trials protocol
Authors: Akboğa Özlem Şahin , Gürkan Aysel
Published: October 2021

Background: This study aims to investigate the effects of individual and combined use of intraoperative forced-air warming and warmed intravenous and irrigation fluids on post-operative body temperature, shivering, thermal comfort, pain, nausea and vomiting in adult patients receiving general anaesthesia.

Methods: This is a randomised controlled clinical trial. A 2x2 factorial design will used in the experiment. Eligible patients will be randomly assigned to one of four groups. We attempt to report this randomized controlled trial to comply with the spirit. The study population will consist of 120 adult patients receiving general anaesthesia at university hospitals in Turkey. After the induction of anaesthesia, the first group (n=30) will be warmed with only forced-air warming device, the second group (n=30) will receive only warmed intravenous and irrigation fluids, forced-air warming as well as warmed intravenous (IV) and irrigation fluids will be applied to the third group (n=30), the fourth group (n=30) will consist of the control group without any intervention. Blood and blood products to be applied intraoperatively to all groups will be heated to 37°C.

Conclusions: The primary outcome measures are post-operative body temperature, shivering, thermal comfort, pain, nausea and vomiting. The primary results will be subjected to a one-way analysis of variance for covariant such as amount of bleeding and volume of intraoperative fluids.

Trial registration: The trial has been registered in clinical trials: https://clinicaltrials.gov/. Registration number: NCT04907617).
Comparison of the hard and soft tissue changes of bimaxillary protrusion patients treated with Begg and MBT techniques: a cephalometric study
Authors: Sarkar Nilanjana , C. Karunakara B. , Goel Sumit , Reddy Sumitra
Published: October 2021

Background: The effective treatment of bimaxillary protrusion needs a sound knowledge of the mechanics and expertise to control the tooth movement and the unwanted side effects. To obtain a desired finish there is a need to study and compare the mechanics used for correction of bimaxillary protrusion. The aim of this study was to quantify and compare the skeletal, dentoalveolar and soft tissue effects of Begg and MBT mechanotherapies in the treatment of bimaxillary protrusion cases.

Methods: In the present study, cephalometric comparison of the two mechanotherapies, Begg and MBT appliances was done retrospectively. The subjects were selected on the basis of pretreatment characteristics. The sample consisted of 40 patients (20 in each group) with an age range of 12-24 years. Pre- and post-treatment cephalograms were taken and traced on 75μm lacquered polyester acetate tracing papers using a 0.05” lead pencil.

Results: The present study showed that Begg and the MBT appliances were equally effective in treating bimaxillary protrusion with first premolar extraction to satisfactory end results. Treatment with both the appliances resulted in significant amount of upper and lower anterior retraction and achievement of a pleasing facial appearance and profile.

Conclusions: Good torque control, if used in Begg mechanotherapy will result in achieving similar treatment outcome as obtained with MBT technique.
Objective degree of freedom in activity as the factor of professional talent formation
Authors: Soboleva Tatyana N.
Published: October 2021

This article is devoted to the poorly studied problem of the objective degree of freedom in activity as the factor of professional talent formation. The study was carried out on a sample of 108 qualified railway drivers using a professional simulator that allows to simulate three degrees of freedom in activity. On the basis of empirical data it is shown that the degree of freedom in activity is manifested in individual productivity. The structures of professional talent, different in composition and degree of integration, are formed depending on the objective degree of freedom in activity.
The feeling of timelessness: Russian right-wing radical thought of the turn of the XIX-XX centuries between the horizons of the past and the future of Russia
Authors: Kazenkov Oleg Y.
Published: October 2021

This article is devoted to the problem of the development of the Russian right-wing radical ideology before and at the beginning of the 1905 Revolution. The author analyzes the papers of some representatives of this political movement in Russia, tracing the process of evolution of their views from utopian to quite clearly politically meaningful and aimed at solving the social, political and economic problems of Russia that were relevant for that time. The purpose of the article is to show the diversity and contradictions in the system of views of right-wing radicals in Russia at the beginning of the XX century. The author comes to the conclusion that the reforms of S. Yu. Witte had a significant impact on the development of right-wing radicalism in Russia, and during the formation of oppositional views towards them, a strongly updated political platform of right-wing radicalism in Russia at the beginning of the XX century emerged. The author attributes these contradictions to the assessment of the Russian monarchy and the ways of Russia's development/ .The author shows that the right-wing radicals considered Russia at the beginning of the XX century as a country with a sick economy and political system, they opposed the import of institutions from the West, considering the Russian civilization to be quite complete and self-sufficient.
Problems of forming a regional quasi-market of social services: from paternalism to competition
Authors: Vlasova Alexandra A. , Galanova Alla-Anna V.
Published: October 2021

The article reflects the results of the analysis of the problems of the formation of a regional quasi-market of social services using the example of the Yaroslavl region in the transition from a state monopoly to competitive relations. It was revealed that the product market boundaries and requirements for the quality of services provided were formed during the Soviet period for state and municipal social services, which creates institutional barriers to entry of socially oriented non-profit organizations into the market. The share of non-governmental social services in the provision of social services in the Yaroslavl region is no more than 20%, and the number of NGOs officially included in the register of social service providers is 3 units. Thus, the authors concluded that the quasi-market of social services is in the process of formation, and it can be described as a “proto-market”. At the same time, it was determined that social oriented NGOs have a number of competitive advantages as providers of social services - they provide low transaction costs for the recipient, an expanded range of services, a greater customer focus. The formation of a sustainable regional model of social services at this stage is associated with further diversification of the subjects of social services, expanding the product boundaries of this market, introducing innovative assistance technologies and increasing both the economic and social efficiency of social services. It seems promising to create a unified regional information system in the Yaroslavl region for providers and recipients of social services, allowing residents of the region to order social services via the Internet with the right to choose a provider and conclude contracts online through authorization on the government services portal.
Pesticides in the Environment and Mitigation Technologies
Authors: Diez M Cristina
Published: October 2021

This widespread use of pesticides for agricultural and non-agricultural purposes has resulted in the presence of their residues in various environmental matrices. The contamination could be on-farm during pesticides manipulation or by wastewaters generated by agroindustrial activities and could be treated efficiently in a biopurification system. This technology with some modifications can be used for treating obsolete pesticides and pharmaceuticals products.
Isolation of Nimbolide from Azadirachta Indica Assisted by Molecular Docking as an Antiproliferative Agent
Authors: Singh Tribhuvan
Published: October 2021

The current study on Nimbolide was performed to identify its Antiproliferative Property Nimbolide from kernels of Azadirachta indica gathered from Ranga Reddy-Dist, was separated dried and changed into coarse powder. The seed was defatted and massed utilizing methanol in soxhlet Apparatus. The methanolic extract acquired from seeds is analyzed under High Performance/pressure Liquid Chromatography by Reverse phase technique for confinement of Nimbolide by Docking of Nimbolide through Molecular Operating Environment programming. This proclaimed Nimbolide has capacity of binding 12.3% to a Glycine 131 experiencing polar associations. Nimbolide interact with Cyclin E, was reclaimed from the Protein Data Bank. Demonstrating that Nimbolide has an agreeable expanded life span (54.32 and 65.16), diminished the viable cells (52.3±1.5 and 32.5±1.3), and volume of tumor (3.2±0.03 and 2.4±0.04).
Continuum-Level Simulations of Biopolymer Networks: A Minireview
Authors: Lin Yuan
Published: October 2021

The mechanical properties of living cells are governed by the cytoskeleton, a network consisting of many different biopolymers together with transient linker proteins [1]. Biopolymers, especially those composed of globular proteins, are known to be semiflexible, that is the persistence length of these filaments is often comparable to their contour length, leading to small, yet significant, thermal fluctuations around a straight conformation and ultimately resulting in mechanical properties far from those exhibited by synthetic materials made of highly flexible polymers [2]. Theoretically, it remains a great challenge to understand/predict how a semiflexible filament network behave because of its many-body nature as well as the coupled elastic and entropic effects involved. For this reason, there has been a growing interest in the direct simulation on computer-generated networks in recent years. Here, we briefly review various continuum-level simulation approaches that have been developed in the past few decades.
Optimal Inventory Strategies for Pharmaceutical Products Incorporating Carbon Emissions
Authors: S Priyan
Published: October 2021

Heart failure (HF) is a major factor contributing to premature death in patients with established cardiovascular (CV) disease. Current cell therapies of HF based on at least two different approaches, in which stem cell transplantation and extracellular vesicles (EV) received from pre-treated cells, were used. Although in HF restoring cardiac function aimed improve survival is target of cell therapy, it is not yet yielded whether isolated EVs from circulating progenitor cells, induced pluripotent stem cells (iPSCs), human embryonic stem cells-derived CV progenitors (hESC-Pg) would be effective translators of reparative signals for cardiac repair. The short communication is depicted the role of different cell strategies in HF. It has emphasized lack of strong evidence of clinical advantages implanted EVs to human cells to iPSCs in HF requires comparison in large clinical trials.
Fast Vision of Two Electrospinning Technique: History, Fundamentals and Applications
Authors: Peón Avés Eduardo 
Published: October 2021

In recent decades the electrospinning technique has gained great interest in the scientific community. It is a simple and versatile technique that allows to obtain polymeric fibers at nanometric and micrometric scales. As a result of the process, two-dimensional and three-dimensional structures formed by fibers can be obtained, these materials have potential application in different industries such as textile, food and biopharmaceutical
Optical Tweezers and Their Applications in Biomedical Engineering
Authors: Zhang Liangmin
Published: October 2021

Optical tweezers is a tool based on strongly focused laser beam trapping force. The force of a laser beam originates from the gradient of electric field containing in the focused laser beam. Laser tweezers has been used increasingly as a unique technique for optical trapping, manipulation, and characterizations of biological cells and dielectric micro- and nano-scale particles. It can also be used to make quantitative measurements of living cells.
Reimagining the relationship between Legal Capability and the Capabilities Approach
Authors: Watkins Dawn
Published: October 2021

Within the literature on public legal education and legal capability, it is commonly stated that the concept of legal capability is closely related to the capabilities approach.  This paper critically examines the nature of this relationship and in Part I seeks to demonstrate that whilst they share some broad affinity, the relationship between legal capability and the capabilities approach is currently disparate in both conceptual and practical terms.  In Part II, the paper goes on to consider what might happen if this relationship is reimagined and the two fields brought closer together.  Aspects of this reimagining are considered in turn under three headings: emphasising choice and opportunity, broadening perspective and promoting participatory approaches.   The paper concludes by summarising the potential advantages and disadvantages of this proposed reimagining, and by raising questions as to whether the implications of establishing a closer relationship between legal capability and the capabilities approach warrant further exploration, or whether it is preferable for the distance to be maintained.
Effect of leaf removal and ripening stage on the content of quercetin glycosides in Sangiovese grapes
Authors: Lanati Donato , Cascio Patrizia , Pollon Matteo , Corona Onofrio , Marchi Dora
Published: October 2021

Quercetin haze has been observed over the last few years in some aged Sangiovese wines. This problem could be due to an excess of the quercetin in the wine. Leaf removal increases the exposition of clusters to sunlight, which may enhance flavonol synthesis in the grapes. In this study, we evaluated the dynamics related to extractable flavonols in grapes grown in three usually defoliated Vitis vinifera (L.) cv. Sangiovese vineyards, whose wines showed quercetin precipitates. The particular structure of the vineyards in which the leaf removal experiments were carried out allowed the influence of vineyard, biotype and rootstock on grape flavonol contents at mid-maturation and technological maturity to be evaluated. The leaves were removed at pre-flowering (early) and at veraison (late). Leaf removal increased the content of extractable glycosidic flavonols in grapes at the two tested ripening stages. In addition, vineyard, biotype and rootstock affected the content of glycosidic flavonols and the interaction between the studied variables was significant. Even though leaf removal induced an increase in extractable quercetin glycosides which can increase the risk of quercetin haze in wine, an examination of the scientific literature on this topic showed that this risk does not depend on the absolute content of these compounds alone.
Sağlık Hizmetlerinde Davranışsal İktisat Yaklaşımı: Türkiye’deki Sağlık Sistemi İçin Öneriler
Authors: SERİM Havva , ARIKAN Gamze
Published: October 2021

Tüm dünyada olduğu gibi Türkiye’de de hükümetler, özel işletmeler ve kurumlar gibi sağlık sektörü oyuncularının karşı karşıya oldukları en önemli zorluklardan biri, sağlık ve bakım hizmetlerinin sürdürülebilirliğini sağlarken, sağlık harcamalarını da sürdürülebilir kılmaktır. Artan obezite oranları, nüfusun yaşlanması ve kronik hastalıklardaki artışlar gibi sağlık sorunları ivedi çözümler gerektirmektedir. Her ne kadar söz konusu sağlık sorunlarının nedenleri ve çözümleri çevresel koşullar ve kamu politikaları ekseninde şekillense de kişilerin sağlık durumlarını belirleyenlerin başında kendi tercih ve davranışları gelmektedir. Tütün kullanımı, kötü beslenme, hareketsizlik ve uygun koruyucu önlemlerin alınmaması gibi davranışlar sıklıkla hastalıklara ve ölümlere neden olmaktadır. Bu nedenle, kişilerin sağlıkla ilgili davranışlarının değiştirilmesi büyük önem arz etmektedir. Ancak sağlıkla ilgili davranışlar birçok unsurdan etkilenmeleri bakımından karmaşık olduğu için, bu durum oldukça zordur. Son yıllarda özellikle psikolojiden yararlandığı içgörülerle dikkat çeken davranışsal iktisat ise insanların neden kendileri için en iyi tercihleri yapamadıklarına ve uzun dönemde sağlıklarını kaybetmek pahasına dürtülerine karşı gelemediklerine ilişkin yeni bir yaklaşım sunmaktadır. Ayrıca, benzer bir yaklaşımla sağlık hizmeti arz edenlerin davranışlarını da ele alarak, sağlık hizmetlerindeki davranışsal engelleri kapsamlı bir biçimde ortaya koymaktadır. Bu çalışmada söz konusu içgörüler dikkate alınarak, davranışsal iktisat araçlarının Türkiye’de daha etkili ancak düşük maliyetli sağlık politika ve programları tasarımında nasıl kullanılabileceği hakkında öneriler sunulmaktadır.
Muhasebe ve Finans Alanındaki Eğitimcilerin Kripto Para Farkındalık Düzeyi
Authors: KUZUDİŞLİ Salih Can , ÇARIKÇI Oğuzhan
Published: October 2021

İnternet teknolojisinin, bilgisayarların ve akıllı telefonların gelişmesi ile birlikte dünya çapında kripto paraların kullanım alanı artmış ve yaygınlaşmıştır. İlk olarak 2008 yılında ortaya çıkan kripto para kavramı devletler ve kişiler açısından önemli bir gelişme olmuştur. Dünya çapında ise birçok kriptografik para birimi bulunmaktadır. Bu kriptografik para birimleri ödeme işlemlerinin elektronik ortamda yapılması, maliyetleri düşürmesi ve hızlı bir şekilde işlemlerin gerçekleştirilebilmesi nedeniyle avantaj sağlamaktadır. Bu çalışmamız da muhasebe ve finans alanındaki eğitimcilerin kripto para farkındalık düzeylerini ve tutumlarını ölçebilmek ve kripto para kullanımı ile ilgili olarak bakış açılarını incelemektir. Bu amaç doğrultusunda 117 eğitimci ile birebir ve uzaktan olacak şekilde anket çalışması yapılmıştır. Verilerin analizi edilebilmesi için SPSS programından faydalanılarak faktör analizi, t testi ve one owey anova testleri uygulanmış ve sonuçları bu kapsam noktasında değerlendirilmiştir
Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Authors: Talebi Marjan , Talebi Mohsen , Farkhondeh Tahereh , Simal-Gandara Jesus , Kopustinskiene Dalia M. , Bernatoniene Jurga , Pourbagher-Shahri Ali Mohammad , Samarghandian Saeed
Published: October 2021

:

Cardiometabolic diseases (CMD) have caused a great burden in terms of morbidity and
mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia,
obesity, and atherosclerosis. They have interlinked pathways, interacting and interconnecting
with each other. The natural flavonoid chrysin has been shown to possess a broad spectrum of
therapeutic activities for human health. Herein, we did an in-depth investigation of the novel mechanisms
of chrysin’s cardioprotection against cardiometabolic disorders. Studies have shown that
chrysin protects the cardiovascular system by enhancing the intrinsic antioxidative defense system.
This antioxidant property enhanced by chrysin protects against several risk factors of cardiometabolic
disorders, including atherosclerosis, vascular inflammation and dysfunction, platelet
aggregation, hypertension, dyslipidemia, cardiotoxicity, myocardial infarction, injury, and remodeling,
diabetes-induced injuries, and obesity. Chrysin also exhibited anti-inflammatory mechanisms
through inhibiting pro-inflammatory pathways, including NF-κB, MAPK, and PI3k/Akt. Furthermore,
chrysin modulated NO, RAS, AGE/RAGE, and PPARs pathways which contributed to the
risk factors of cardiometabolic disorders. Taken together, the mechanisms in which chrysin protects
against cardiometabolic disorder are more than merely antioxidation and anti-inflammation in
the cardiovascular system.
Formulation and Characterization of Rutin Loaded Chitosan-alginate Nanoparticles: Antidiabetic and Cytotoxicity Studies
Authors: Palei Narahari N. , Surendran Vijayaraj
Published: October 2021

Background:

The rutin loaded chitosan-alginate nanoparticles (RCANP) were prepared
using an ion gelation method. The optimized RCANP4 formulation composed of rutin: alginate:
chitosan with the ratio of 1.24:5:2. The particle size, zeta potential, and entrapment efficiency of
RCANP4 formulation were found to be 168.4 ± 11.23 nm, -24.7 ± 1.5 mV, and 91.23 ± 1.1%, respectively.
The in vitro drug release of RCANP4 formulation was found to be 88.89 ± 2.9% within
24 h. The Fourier transform infrared spectroscopy (FT-IR) of RCANP4 revealed all characteristic
groups of rutin, confirming the successful loading of rutin into the nanoparticles.

Methods:

Due to rutin entrapment in the chitosan sodium alginate matrix, a broad curve was observed
in the Differential Scanning Calorimetry (DSC) study of RCANP4. The RCANP4 was
found to be uniform and spherical revealed from Scanning Electron Microscopy (SEM) and Transmission
Electron Microscopy (TEM). RCANP4 showed 3.54 times more bioavailability than free
rutin, resulting in more internalization of rutin in systemic circulation. The results of plasma glucose
levels of diabetic rats administered with RCANP4 and rutin were evident that RCANP4
showed effective antidiabetic activity compared to rutin.

Results:

The results obtained for glucose uptake in HepG2 cells, the RCANP4 caused a significant
(P < 0.05) increase in glucose uptake in contrast to rutin. In vitro cytotoxicity results explained that
RCANP4 could significantly (P < 0.05) reduce the cells viability rate compared with rutin. It may
be due to the internalization of RCANP4 formulations in systemic circulation.

Conclusion:

The results also showed that RCANP4 could significantly reduce cell viability over
24 h and 48 h compared to free rutin.
The Potential Role of C-peptide in Sexual and Reproductive Functions in Type 1 Diabetes Mellitus: An Update
Authors: Pujia Roberta , Maurotti Samantha , Coppola Adriana , Romeo Stefano , Pujia Arturo , Montalcini Tiziana
Published: October 2021

Background:

Although hyperglycaemia is known to be the leading cause of the diabetic complications, the beneficial effect of an optimal glucose control on the prevention of diabetic complications is still far from being proven. In fact, such complications may not to be related to glycaemic control alone.

Objective:

This review summarizes several studies that suggest that a C-peptide deficiency could be a new and common pathophysiology for complications in type 1 diabetes including sexual and reproductive dysfunction.

Method:

We reviewed in vitro, in vivo and human studies on the association between C-peptide deficiency or C-peptide replacement therapy and complications in type 1 diabetes. It seems that C-peptide replacement therapy may interrupt the connection between diabetes and sexual/reproductive dysfunction.

Results :

The Diabetes Control and Complications Trial suggested that maintaining C-peptide secretion is associated with reduced incidence of retinopathy, nephropathy and hypoglycaemia. Risk of vascular, hormonal and neurologic damage in the structures supplying the penis increases with increasing levels of HbA1. However, several human studies suggested that there is an association between C-peptide production and hypothalamic/pituitary functions. When exposed to C-peptide, cavernosal smooth muscle cells increase the production of nitric oxide. Compared with non-treated diabetic rats, C-peptide in diabetic rats improves sperm count, sperm motility, testosterone levels, and nerve conduction.

Conclusion:

C-peptide deficiency may be involved, at least partially, in the development of several pathological features associated with type 1 diabetes including sexual/reproductive dysfunction. Preliminary studies reported that C-peptide administration protects against diabetic micro- and macrovascular damages as well as sexual/reproductive dysfunction. Therefore, further studies are now needed to confirm these promising findings.
Development of soft actuators for stroke rehabilitation using deep learning
Authors:   Mechanical Engineering, University of Ha’il, Ha’il, Saudi Arabia, et al. Al-Shammari
Published: October 2021

Automation has created a mind-blowing impact in diversified fields all over the world. Not only in business but also in various domains like health care sectors, manufacturing, etc. a faultless execution is a prime concern. Robotic Process Automation has paved the way for research in the mechanical and mechatronics field. Software robots are trained well to complete repetitive tasks in an efficient manner. A design of such a soft robot can be greatly helpful in the arena of healing. Automation of Rehabilitation therapy has gained attention in recent years. The main aspiration towards the conduct of this research work is to accomplish a soft exoskeleton robot using a thin McKibben actuator applying Deep Learning approaches to aid automatic therapy to the paralyzed patients and help them carry out the hand movement-based exercises. Convolutional Neural Network (CNN) algorithm will be used to support the training of the AI-enabled automated device. The proposed methodology will support stroke survivors to perform exercises independently to enhance their hand motor recovery. For this purpose, it involves pneumatic soft actuator technology using thin McKibben artificial muscles to create a cognitive potential to induce rehabilitation. A soft actuator is proposed so as to confirm the safety purposes of stroke patients.
An Evidence Map on Serious Games in Preventing Sexually Transmitted Infections Among Adolescents: Systematic Review About Outcome Categories Investigated in Primary Studies
Authors: Ilskens Karina , Wrona Kamil J , Dockweiler Christoph , Fischer Florian
Published: October 2021

Background

Sexually transmitted infections (STIs) represent a global health risk. Adolescents are at increased risk of infection for several reasons such as lack of knowledge, risky sexual behaviors, and lack of behavioral sills (eg, to negotiate safer sex). Given the fact that adolescents often use digital media and that serious games are considered to have the potential to change knowledge, attitudes and behavior, serious games represent an opportunity for the prevention of STIs.

Objective

The aim of this systematic review was to identify and systematically summarize the dimensions that have been investigated in primary studies on serious games targeting STI prevention among adolescents.

Methods

A systematic review was conducted in PubMed and Web of Science. Studies published from 2009 to 2021 were included that assessed the effectiveness of serious games on adolescent sexual health. A total of 18 studies met the inclusion criteria and were categorized according to dimensions of effectiveness and user experience.

Results

Various dimensions of effectiveness and aspects of user experience were investigated in the primary studies. In total, 9 dimensions of effectiveness were observed: sexual behavior, behavioral intentions, knowledge, attitudes and beliefs, self-efficacy and personal limitations, character traits and future orientation, environmental and individual risk factors, risk perception and risk assessment, as well as normative beliefs and (social) norms. Furthermore, several dimensions related to user experience were investigated in primary studies, that is, motivation, acceptability, trustworthiness, comprehensibility, handling and control, perceived effectiveness, as well as satisfaction.

Conclusions

This review provides an overview of serious games interventions that are vastly different in approach, content, and even platform. In previous studies, knowledge has already been comprehensively assessed, and a positive influence of serious games on knowledge about sexual topics is evident. The results clearly show that adolescents’ sexual knowledge has been increased by the serious games interventions. However, methodological and content differences in the surveys make it difficult to draw conclusions about the effectiveness related to changes in attitudes and behavior.
Decision-making Factors Toward the Adoption of Smart Home Sensors by Older Adults in Singapore: Mixed Methods Study (Preprint)
Authors: Cao Yuanyuan , Erdt Mojisola , Robert Caroline , Naharudin Nurhazimah Binte , Lee Shan Qi , Theng Yin-Leng
Published: October 2021

BACKGROUND

An increasing aging population has become a pressing problem in many countries. Smart systems and intelligent technologies support aging in place, thereby alleviating the strain on health care systems.

OBJECTIVE

This study aims to identify decision-making factors involved in the adoption of smart home sensors (SHS) by older adults in Singapore.

METHODS

The study involved 3 phases: as an intervention, SHS were installed in older adults’ homes (N=42) for 4 to 5 weeks; in-depth semistructured interviews were conducted with 18 older adults, 2 center managers, 1 family caregiver, and 1 volunteer to understand the factors involved in the decision-making process toward adoption of SHS; and follow-up feedback was collected from 42 older adult participants to understand the reasons for adopting or not adopting SHS.

RESULTS

Of the 42 participants, 31 (74%) adopted SHS after the intervention, whereas 11 (26%) did not adopt SHS. The reasons for not adopting SHS ranged from privacy concerns to a lack of family support. Some participants did not fully understand SHS functionality and did not perceive the benefits of using SHS. From the interviews, we found that the decision-making process toward the adoption of SHS technology involved intrinsic factors, such as understanding the technology and perceiving its usefulness and benefits, and more extrinsic factors, such as considering affordability and care support from the community.

CONCLUSIONS

We found that training and a strong support ecosystem could empower older adults in their decision to adopt technology. We advise the consideration of human values and involvement of older adults in the design process to build user-centric assistive technology.
Prevent Electrical Accidents When Working Alone
Authors: Sharma Dr. Abhinav
Published: October 2021

Abstract: Electrical hazards cause more than 300 electrocutions and 4,000 injuries in the workplace each year, disrupting lives and impacting the productivity of companies. While electrical hazards are not the leading cause of on-the-job injuries, accidents and fatalities, they are disproportionately fatal and costly. Over the past 10 years, more than 46,000 workers have been injured from on-the-job electrical hazards. These injuries are not isolated to any one industry or field of work and most could be easily avoided. Awareness of electrical hazards is critical to avoiding and preventing accidents. It is always important to ensure an employee is properly trained and qualified for a job. Not understanding the circumstances about the job can lead to accidents and injuries. Even properly qualified workers are susceptible to accidents. That’s why it’s important to make safety an integral part of the planning process for every job. Keywords: Accidents, Electrical hazards, Fatal, Injuries.
Scientific and Theoretical Analysis of the Destructive Nature of Modern Terrorism
Authors: Yurievna Sultanova Svetlana
Published: October 2021

Annotation: Terrorism is one of the most painful universal problems of the modern world. In the fight against modern terrorism in the context of globalization, the spiritual development of a person is an important socially significant factor. Socio-economic, political, spiritual and educational development of society is one of the important factors in the fight against terrorism, extremism and fundamentalism. In this context, the study of the negative impact of international terrorism on the spiritual development of the individual in the modern world in the context of social philosophy is an important scientific and theoretical problem. Keywords: terrorism, global politics, terrorist act, extremism-radicalism, logocentrism, monologism, dogmatism.
The methods and norms of transferring Spanish and Georgian proper names into Georgian language
Authors:   Ivane Javakhishili Tbilisi State University, Tbilisi, Georgia, Kobeshavidze Marine , Peikrishvili Sofio ,   Ivane Javakhishili Tbilisi State University, Tbilisi, Georgia, Khuskivadze Ketevan ,   Ivane Javakhishili Tbilisi State University, Tbilisi, Georgia
Published: October 2021

Nowadays Georgia is faced with the economic, political and social problems, by which the integration process with the European Union is accompanied. The Association Agreement has given rise to the new challenges that finally aims at providing the collaboration among the member states of EU, including Spain on the issues such as economy, education, tourism, emigration policy, legal cooperation and safety. The language along this line is the essential tool for the development of international relations. In this respect, the accurate translation of toponyms, anthroponyms and legal terms into the foreign language is of utmost importance. The paper deals with the research conducted on these topics, in particular, by the example of Spanish and Georgian - the two languages belonging to extremely distant language families, which differ from each other from the syntactic, morphological and structural aspects and have distinct alphabets and phonetic systems. The paper mainly focuses on informing the findings of the still ongoing research, which will be beneficial to the linguists as well as the translators in the fields of diplomacy, law and politics. It is the first time the research has been conducted from the above - mentioned aspects, which, in its turn, develops certain complications. In addition, based on the historical background, the involvement of the third- Russian language in the ongoing processes makes some difficulties, as well.
Gender Issue in Georgian General Education Institutions
Authors:   Batumi Shota Rustaveli State University, Georgia, Mikeladze Madona , Shamilishvili Inga ,   Batumi Shota Rustaveli State University, Georgia
Published: October 2021

Gender Equality is one of the principles of functioning democratic society. It is clear that this principle should be integrated into the education system itself. Georgia, as in the State, has taken on commitment to establishing gender equality in the education system in recent years. “The Georgian Law on Gender Equality” (Chapter 2, Article 6) separates the equality guarantees in relation with education. “The State Action Plan for Gender Equality” determines the whole spectrum of measures for achieving gender equality in education. However, everyday practice is far from the desirable situation because of not understanding equality principles. The school, as one of the most important institutions of gender socialization, can create the conditions for the development of children of both sexes, as well as it can become the factor of the gender inequality and transmission. Gender inequality within the education system can be seen in the aspects such as education policy and development strategy, institutional aspects, educational programs and content of textbooks, teaching approaches, assessment forms, organizing physical environment, etc. Of course, it is of great importance that the gender-character of formal and informal relations of the subjects involved in the education process, i.e. the specificity of relations among teachers, administration and pupils. The study provides an analysis of teacher behavior, gender attitudes and stereotypes towards the children of different sexes as well as the gender sensitivity of teachers, pupils and parents in Georgian educational space.
A Good General Education School for the New Generation: Illusion or Reality
Authors:   Vilnius University (Lithuania), Targamadze Vilija , Manjgaladze Mariam ,   Ivane Javakhishvili Tbilisi State University
Published: October 2021

The 21st century poses challenges to the general education school, which not only has to respond to the needs of education, culture, national and global context and others but also to focus on the new generation possessing specific features. The question arises: Can the new general education school be created for the new generation? If yes, what aspects of its development should be evaluated? The aim of the article is to highlight the aspects in the design of the good general education school creation. It studies the new generation in terms of their characteristics and the Conception of Good School (2015), which can become a map designing the school for the new generation. Highlighting the essence of this conception, it is emphasised that “The Good School is the one that is built on underlying humanistic values, strives for the success of discovery and personal development, and follows the school community's agreements and learning in its activities“(Geros mokyklos koncepcija, 2015: p.1). The possible school models can also be analysed. Undoubtedly, the school model can be different, linking formal and non-formal education, the real and virtual environments. Moreover, it is possible to construct various activities on the basis of community agreements, to employ various forms, methods and ways of education, even to modify the curriculum but it is even more important to ensure the child-centred education, which allows responding to children's needs and interests and observing their compatibility with those of society. The gap between the real and the virtual spaces should be avoided and their possibilities and potential for improvement of children's education should be fully used
The Effective Provision of Preschool Bilingual Education (On the example of Greece)
Authors:   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, Beridze Teona
Published: October 2021

The present article: ″The Effective Provision of Preschool Bilingual Education (on the example of Greece)″ aims to study and analyse the problem of bilingualism, bilingual education at pre-school age, bilingual memory and the relationship between first and second languages in this context, innovative methods of teaching a second language and psychological factors influencing a child. Some main factors that influence success in second language acquisition: integration, motivation, instrumental motivation, language skills self-esteem and child's nursery self-concept. The interest of the given research contains: the observation on kindergartens pupils in the city of Athens and Attica region. One of the core objectives of the research is to determine amount of bilingual children in the kindergartens every year, the teachers’ and pupils’ role in learning foreign language. The article focuses on the questions regarding the use and development of language of bilingual children in a kindergarten, aims at studying psychology related to bilingual children, using different approaches of modern methods, creating an effective teaching plan intended to meet learning outcomes relying on good results at the end of the year, making parents aware of children's problems, arranging frequent contacts between parents and teachers, exchanging of the ideas as well. We have conducted extensive research and interviews among teachers in kindergartens. According to the interviews we found out that, kindergartens are quite highly developed and among twenty three interviewed teachers we can say that they are sufficiently qualified and adequately prepared in order to give all bilingual children opportunities for a good quality education relating to learning the Greek language easily. Bilingual education can completely promote positive attitudes to a child. Developing learning skills of two languages simultaneously is important in the child's daily experiences