bluuebunny/crossref_metadata_2025 huggingface dataset:
GUI Based Inversion Code for Automatic Quantification of Strike Limited Listric Fault Sources and Regional Gravity Background from Observed Bouguer Gravity Anomalies
Authors: Chakravarthi V. , Sastry S. Rajeswara
Published: June 2014

A method coupled with a GUI based code in JAVA is developed in the space domain to simultaneously estimate the structures of strike limited listric fault sources and regional gravity background from a set of observed Bouguer gravity anomalies. The density contrast within the hanging wall of the structure is assumed to be varying continuously with depth based on a parabolic equation. The limiting surface of the fault plane is described with an exponential function. This method is automatic in the sense that it initializes both parameters of a strike limited listric fault source and regional gravity background from a set of observed Bouguer gravity anomalies and improves them iteratively until the modeled gravity anomalies fit the observed anomalies within the specified convergence criteria. The advantage of the code is that besides generating output in both ASCII and graphical forms it displays the animated versions of (i) the changes in model geometry, (ii) variation of each model parameter and misfit with iteration number, (iii) improvements in modeled gravity anomalies, and (iv) variation of density contrast with depth. The applicability of the code is demonstrated on both synthetic and real field gravity anomalies. In case of synthetic example pseudorandom noise is added to the residual gravity anomalies of the structure prior to inversion. The noisy anomalies are then inverted for the unknown parameters presuming (i) an ideal listric fault structure bounded by an exponential limiting surface with perfect flat top and bottom surfaces, (ii) non-ideal structure with uneven top and bottom surfaces with imperfect exponential limiting surface. Further, the robustness of the algorithm is exemplified by adding both regional gravity background and pseudorandom noise to the anomalies of the structure before inversion. In all cases, the interpreted parameters of the structure closely mimic the assumed parameters. The interpretation of gravity anomalies across the master fault of the Chintalpudi sub-basin in India has yielded information that is consistent with both DSS results and drilling information. The highlight of the code is that it can be used to interpret the gravity anomalies of listric fault sources even when the profile along which the interpretation is intended fails to bisect the strike length of the structure.
Estimation of Maximum Magnitude (Mmax): Impending Large Earthquakes in Northeast Region, India
Authors: Mohapatra Alok K. , Mohanty William K. , Verma Akhilesh K.
Published: June 2014

In the present study, the cumulative seismic energy released by earthquakes (Mw ≥ 5) for a period of 1897 to 2009 is analyzed for northeast (NE) India. For this purpose, a homogenized earthquake catalogue in moment magnitude (Mw) has been prepared. Based on the geology, tectonics and seismicity, the study region is divided into three source zones namely, 1: Arakan-Yoma Zone (AYZ), 2: Himalayan Zone (HZ) and 3: Shillong Plateau Zone (SPZ). The maximum magnitude (Mmax) for each source zone is estimated using Tsuboi’s energy blocked model. As per the energy blocked model, the supply of energy for potential earthquakes in an area is remarkably uniform with respect to time and the difference between the supply energy and cumulative energy released for a span of time, is a good indicator of energy blocked and can be utilized for the estimation of maximum magnitude (Mmax) earthquakes. The proposed process provides a more consistent model of gradual accumulation of strain and non-uniform release through large earthquakes can be applied in the assessment of seismic hazard. Energy blocked for source zone 1, zone 2 and zone 3 regions is 1.35×1017 Joules, 4.25×1017 Joules and 7.25×1017 Joules respectively and will act as a supply for potential earthquakes in due course of time. The estimated Mmax for each source zone AYZ, HZ, and SPZ are 8.2, 8.6, and 8.7 respectively. Mmax obtained from this model is well comparable with the results of previous workers from NE region.
Rodent Fossils from Dharmsala Group in Himachal Pradesh: Addition to pre-Siwalik Himalayan Miocene Fauna
Authors: Bhandari Ansuya , Tiwari B. N.
Published: June 2014

Abstract: While constraining Cenozoic evolution of the Himalaya through enlightening fossils we find that Dharmsala Group (intervening Subathu Group and Siwalik Group) in Kangra Valley and adjoining coevals yield sporadic fossils. Hence, this first record of fossil rodents from Dharmsala Group is an important addition to an earlier report of dinothere from these horizons. The rodent material from grey facies of the Dharmsala Group comprises of an isolated premolar and fragments of a tooth and an incisor. Available crown details in conjunction with distinctive dimensions of the premolar lead to its assignment to Hodsahibia, a baluchimyine taxon; this taxon of Eocene lineage of south Asian-African distribution is already on record from early Oligocene horizons in Bugti area, Pakistan.
Comparison of Results of BIS and GSI Guidelines on Macrolevel Landslide Hazard Zonation – A Case Study along Highway from Bhalukpong to Bomdila, West Kameng District, Arunachal Pradesh
Authors: Singh C. D. , Kohli Atul , Kumar Pankaj
Published: June 2014

This paper compares the findings of macrolevel landslide hazard zonation carried out along the highway from Bhalukpong to Bomdila, West Kameng district, Arunachal Pradesh following GSI and BIS guidelines. The map resulted from the GSI guideline shows that 69.31% of the faceted area falls under the Low Hazard Zone (LHZ) while 17.69%, 7.31%, 5.03% and 0.65% of the area are in Moderate Hazard Zone (MHZ), High Hazard Zone (HHZ), Very Low Hazard Zone (VLHZ) and Very High Hazard Zone (VHHZ) respectively. Correlation between the landslide incidences and different hazard zones reveals that maximum failure percentage is in VHHZ and it is followed by HHZ, MHZ and LHZ. The second map resulting from BIS guideline reveals that 45.77% of the faceted area falls under MHZ while 41.39%, 11.52% and 1.29% of the area are in HHZ, LHZ and VHHZ respectively. Not a single facet falls in VLHZ. With regard to failure percentage VHHZ experiences 50%, while that of HHZ, MMH and LHZ is roughly 11.5% each. In the study area, the landslide hazard zonation map resulting from GSI guideline broadly conforms to field condition. It may be due to the fact that the study area is along the road corridor where slope cutting and landslides are very common and GSI guideline considers both the slope cutting and landslide parameters, while it is not so in the case of BIS guidelines. However, a final conclusion can be drawn after carrying out such studies in different geological settings.
Palynology and Depositional Facet of Lower Permian (Artinskian) Sediments from New Majri Opencast Mine, Wardha Basin, India
Authors: Mahesh S. , Sabina K. Pauline , Bilwa L. Mahesh
Published: June 2014

Coal samples and the associated sediments from New Majri open cast mine have been analysed palynologically with the following objectives: to date the sediments on the basis of the palyno-assemblage recognised; to carry out an inter-basinal, intra-basinal and Gondwana wide correlation; to interpret the palaeoenvironment and depositional facet of the coal field on the basis of dispersed organic matter analysis and sedimentary facies analysis.

Based on the qualitative and quantitative analysis of the spore and pollen content one palyno-assemblage-Scheuringipollenites and Faunipollenites has been recognised which is typical of lower Barakar Formation. This has been correlated with known palyno-assemblages from Wardha basin and other basins in India, while with the Gondwana continents the assemblage has been broadly correlated with early Permian Australian, African, South America palynofloras as well as early Permian palynoflora of Antarctica. Consequently, a tentative late Early Permian, Artinskian age is proposed for the sediments from New Majri open cast mine. Palynological studies also revealed that the peat forming vegetation was mainly composed of gymnosperms represented by glossopterids (Scheuringipollenites, Ibisporites, Platysaccus, Cuneatisporites, Primuspollenites and Sahnites), conifers (Faunipollenites, Striatites, Striatopodocarpites, Verticipollenites, Distriatites) and cordaites (Parasaccites, Plicatipollenites, Crucisaccites, Divarisaccus, Densipollenites). Spores were represented mainly by filicopsids (Horriditriletes, Brevitriletes, Callumispora) and sphenopsids (Latosporites). The relative abundance of structured organic matter implies the existence of a fairly dense cover of vegetation in the hinterland. Anaerobic, reducing, water logged peat-forming conditions have been inferred by the presence of biodegraded organic matter and amorphous organic matter. The charcoal fragments recovered from the present study area reflects a possible wildfire in the accumulated swamps or a wildfire in the hinterland after which the sediments were flushed by fluvial systems into the swamps. The coalfield exhibits horizontal bedding pattern which may be due to deposition by suspension settling or horizontal accretion. Further the alternating high and low energy regime is noticed in the sandstone-shale intercalated beds overlying the coarse grained yellow sandstone which forms the roof of the coal seam. Comprehensively the sediments are deposited as overbank / levee deposits.
Effects of microRNA‐30a on migration, invasion and prognosis of hepatocellular carcinoma
Authors: Liu Zhaoyang , Tu Kangsheng , Liu Qingguang
Published: June 2014

The role of microRNA‐30a (miR‐30a) deregulation in tumor progression and its downstream signaling pathways remain unknown. Here we confirmed significant downregulation of miR‐30a in hepatocellular carcinoma (HCC) tissues and cell lines compared with non‐tumor counterparts. MiR‐30a downregulation was significantly associated with worse disease‐free survival (DFS) of HCC patients. Gain‐ and loss‐of‐function studies revealed that downregulation of miR‐30a facilitated tumor cell migration, invasion and epithelial–mesenchymal transition (EMT). We identified SNAI1 as a direct target of miR‐30a and demonstrated miR‐30a as a novel regulator of EMT by targeting SNAI1, indicating its potential therapeutic value for reducing invasion and metastasis of HCC.
TRAP1‐dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: Relevance in human colorectal tumors
Authors: Matassa Danilo Swann , Agliarulo Ilenia , Amoroso Maria Rosaria , Maddalena Francesca , Sepe Leandra , Ferrari Maria Carla , Sagar Vinay , D'Amico Silvia , Loreni Fabrizio , Paolella Giovanni , Landriscina Matteo , Esposito Franca
Published: June 2014

TNF receptor‐associated protein 1 (TRAP1) is an HSP90 chaperone involved in stress protection and apoptosis in mitochondrial and extramitochondrial compartments. Remarkably, aberrant deregulation of TRAP1 function has been observed in several cancer types with potential new opportunities for therapeutic intervention in humans. Although previous studies by our group identified novel roles of TRAP1 in quality control of mitochondria‐destined proteins through the attenuation of protein synthesis, molecular mechanisms are still largely unknown. To shed further light on the signaling pathways regulated by TRAP1 in the attenuation of protein synthesis, this study demonstrates that the entire pathway of cap‐mediated translation is activated in cells following TRAP1 interference: consistently, expression and consequent phosphorylation of p70S6K and RSK1, two translation activating kinases, are increased upon TRAP1 silencing. Furthermore, we show that these regulatory functions affect the response to translational stress and cell migration in wound healing assays, processes involving both kinases. Notably, the regulatory mechanisms controlled by TRAP1 are conserved in colorectal cancer tissues, since an inverse correlation between TRAP1 and p70S6K expression is found in tumor tissues, thereby supporting the relevant role of TRAP1 translational regulation in vivo. Taken as a whole, these new findings candidate TRAP1 network for new anti‐cancer strategies aimed at targeting the translational/quality control machinery of tumor cells.
Identification of a new androgen receptor (AR) co‐regulator BUD31 and related peptides to suppress wild‐type and mutated AR‐mediated prostate cancer growth via peptide screening and X‐ray structure analysis
Authors: Hsu Cheng-Lung , Liu Jai-Shin , Wu Po-Long , Guan Hong-Hsiang , Chen Yuh-Ling , Lin An-Chi , Ting Huei-Ju , Pang See-Tong , Yeh Shauh-Der , Ma Wen-Lung , Chen Chung-Jung , Wu Wen-Guey , Chang Chawnshang
Published: June 2014

Treatment with individual anti‐androgens is associated with the development of hot‐spot mutations in the androgen receptor (AR). Here, we found that anti‐androgens‐mt‐ARs have similar binary structure to the 5α‐dihydrotestosterone‐wt‐AR. Phage display revealed that these ARs bound to similar peptides, including BUD31, containing an Fxx(F/H/L/W/Y)Y motif cluster with Tyr in the +5 position. Structural analyses of the AR‐LBD‐BUD31 complex revealed formation of an extra hydrogen bond between the Tyr+5 residue of the peptide and the AR. Functional studies showed that BUD31‐related peptides suppressed AR transactivation, interrupted AR N‐C interaction, and suppressed AR‐mediated cell growth. Combination of peptide screening and X‐ray structure analysis may serve as a new strategy for developing anti‐ARs that simultaneously suppress both wt and mutated AR function.
Increase of MET gene copy number confers resistance to a monovalent MET antibody and establishes drug dependence
Authors: Martin Valentina , Corso Simona , Comoglio Paolo M. , Giordano Silvia
Published: June 2014

The relevant role in cancer played by the tyrosine kinase receptor encoded by the MET oncogene led to the development of specific inhibitors, some of which are now in advanced phases of clinical trials. Previous experience has shown that the main limit to the efficacy of most targeted treatments is the advent of resistance. Mechanisms underlying resistance to MET‐specific small tyrosine kinase inhibitors (TKIs) have been already described, while nothing is known about resistance to MET monoclonal antibodies, nor about bypassing resistance to chemical TKIs by antibodies or vice‐versa. EBC1 lung cancer cells are MET‐addicted as a consequence of gene amplification and thus sensitive to MET inhibitors, including the monovalent form of a MET monoclonal antibody (MV‐DN30). We generated cells resistant to this antibody and found that resistance was due to a further increase of gene copy number and a dramatic overexpression of the MET receptor. Such an excess of expression saturated the ‘shedding’ activity of MV‐DN30, and prevented both the efficient down‐regulation of the MET receptor from the surface and the inhibition of the ensuing constitutive activation. Notably, antibody‐resistant cells remained MET‐‘addicted’ and were still sensitive to MET TKIs. Moreover, antibody‐resistant cells became ‘drug‐dependent’, since the removal of MV‐DN30 led them to death due to excess of signal. In the mirror experiment, cells made resistant to MET‐specific TKIs were still sensitive to treatment with the antibody MV‐DN30. These findings suggest that a discontinuous, combined treatment by antibodies and chemical kinase inhibitors may increase the clinical response and bypass resistance to anti‐MET targeted therapies.
Granular jet impact: probing the ideal fluid description
Authors: Müller Patric , Formella Arno , Pöschel Thorsten
Published: June 2014

We investigate the impact of a granular jet on a finite target by means of particle simulations. The resulting hydrodynamic fields are compared with theoretical predictions for the corresponding flow of an incompressible and rotation-free fluid. The degree of coincidence between the field obtained from the discrete granular system and the idealized continuous fluid flow depends on the characteristics of the granular system, such as granularity, packing fraction, inelasticity of collisions, friction and target size. In certain limits we observe a granular–continuum transition under which the geometric and dynamic properties of the particle jet and the fluid jet become almost identical.
BOTH SIDES NOW: THE CARP'S-TONGUE COMPLEX REVISITED
Authors: Brandherm Dirk , Moskal-del Hoyo Magdalena
Published: June 2014

Engaging with both typological and contextual approaches, this paper endeavours to take a fresh look at one of the most emblematic groups of Atlantic Late Bronze Age metalwork depositions. Taking a revised typo-chronology for carp's-tongue swords as a starting point, we compare single-piece deposition of these items with their occurrence in hoards of mixed composition. Clear regional trends emerge as a result. We also contrast the composition of carp's-tongue hoards on both sides of the English Channel, highlighting the impact that poorly defined key types can have on our perception of an entire complex of metalwork assemblages. Overall, the composition of carp's-tongue hoards proves rather uniform across this geographical divide. Some noteworthy differences, however, can be discerned between British and French assemblages.
Niche Party Success and Mainstream Party Policy Shifts – How Green and Radical Right Parties Differ in Their Impact
Authors: Abou-Chadi Tarik
Published: June 2014

This article investigates the impact of niche party success on the policy agendas of mainstream parties. Following from the expected electoral effects of issue politicization, the success of radical right and green parties will cause different reactions from mainstream parties. While mainstream parties emphasize anti-immigrant positions in response to radical right success, green party success will have the opposite effect for environmental issues. Since green parties constitute issue owners, their success will make established parties de-emphasize the environment. Analyzing time-series cross-section data for sixteen Western European countries from 1980 to 2011, this article empirically establishes that green and radical right parties differ in their effect on mainstream party behavior and that their impact depends on the ideological position and past electoral performance of the mainstream parties.
CNOOC-Nexen, State-Controlled Enterprises and Canadian Foreign Investment Policies: Adapting to Divergent Modernization
Authors: Hale Geoffrey
Published: June 2014

This article examines the evolving debate over takeover bids by foreign state-owned and influenced enterprises (SOEs) in the context of CNOOC's successful 2012 acquisition of Nexen Inc., historical debates over foreign investment in Canada and the ongoing adaptation of Canadian trade and investment policies to global shifts in economic activity and power. It views SOE-related policy changes as responses to four broad factors: Canada's adaptation to changing global investment patterns as a small, open economy, efforts to diversify Canada's trade and investment relations while balancing domestic regional and sectoral interests, the extension of trade-related principles of reciprocity to investment policies and competition among governmental and economic interests in the allocation of discretion in corporate governance and related regulatory policies.
Growth-promoting effects of pepsin- and trypsin-treated caseinomacropeptide from bovine milk on probiotics
Authors: Robitaille Gilles , Champagne Claude P
Published: June 2014

Probiotic Lactobacillus and Bifidobacterium species are generally fastidious bacteria and require rich media for propagation. In milk-based media, they grow poorly, and nitrogen supplementation is required to produce high bacterial biomass levels. It has been reported that caseinomacropeptide (CMP), a 7-kDa peptide released from κ-casein during renneting or gastric digestion, exhibits some growth-promoting activity for lactobacilli and bifidobacteria. During the digestive process, peptides derived from CMP are detected in the intestinal lumen The aim of this study was to evaluate the effects of peptic and tryptic digests of CMP on probiotic lactic acid bacteria growth in de Man, Rogosa and Sharpe broth (MRS) and in milk during fermentation at 37 °C under anaerobic conditions. The study showed that pepsin-treated CMP used as supplements at 0·5 g/l can promote the growth of probiotics even in peptone-rich environments such as MRS. The effect was strain-dependent and evident for the strains that grow poorly in MRS, with an improvement of >1·5 times (P<0·05) by addition of pepsin-treated CMP. Trypsin-treated CMP was much less efficient as growth promoter. Moreover, pepsin-treated CMP was effective in promoting the growth in milk of all probiotic lactic acid bacteria tested, with biomass levels being improved significantly, by 1·7 to 2·6 times (P<0·05), depending on the strain. Thus, supplementation of MRS and of milk with pepsin-treated CMP would be advantageous for the production of high biomass levels for Bifidobacteria and Lactobacilli.
The Strategic Listing Decisions of Hedge Funds
Authors: Jorion Philippe , Schwarz Christopher
Published: June 2014

The voluntary nature of hedge fund database reporting creates strategic listing opportunities for hedge funds. However, little is known about how managers list funds across multiple databases or whether investors are fooled by funds’ listing decisions. In this paper, we find that hedge funds strategically list their small, best-performing funds in multiple outlets immediately while preserving the option to list their other funds in additional databases later. We generally find that investors react rationally to these fund listings based on the predictability of performance. Finally, our results lead to specific guidelines on handling backfilled returns to minimize biases.
Revisiting the pathways to retirement: a latent structure model of the dynamics of transition from work to retirement
Authors: TANG FENGYAN , BURR JEFFREY A.
Published: June 2014

A dynamic latent structure model of the work–retirement transition process was identified, focusing on transitions of work and retirement status for men and women aged 51–74 years. Using the Health and Retirement Study data (1998–2004), latent transition analysis was used to identify a best fitting model capturing work–retirement statuses in four samples defined by age and sex. The prevalence of each status was described and the dynamic transition probabilities within the latent structure were examined. Using multinomial logistic regression, socio-demographic, health, family and occupational factors were assessed to determine how each was related to the likelihood of occupying a specific latent status at baseline. Results showed that study respondents were classified into distinct groups: full retiree, partial retiree or part-time worker, full-time worker, work-disabled or home-maker. The prevalence of full retiree status increased, while the prevalence for full-time worker status decreased over time for both men and women. Membership rates in the work-disabled and partial retiree status were generally consistent, with decreased probabilities of the work-disabled status in the older age groups and increased probabilities of partial retirees among younger men. Our findings indicated that many older Americans experience multiple transitions on the pathway to retirement. Future research on late-life labour-force transitions should evaluate the impact of the recent Great Recession and examine the role of larger socio-economic contexts.
A Pedestrian Navigation System Based on Low Cost IMU
Authors: Li Yan , Jack Wang Jianguo
Published: June 2014

For indoor pedestrian navigation with a shoe-mounted inertial measurement unit (IMU), the zero velocity update (ZUPT) technique is implemented to constrain the sensors' error. ZUPT uses the fact that a stance phase appears in each step at zero velocity to correct IMU errors periodically. This paper introduces three main contributions we have achieved based on ZUPT. Since correct stance phase detection is critical for the success of applying ZUPT, we have developed a new approach to detect the stance phase of different gait styles, including walking, running and stair climbing. As the extension of ZUPT, we have proposed a new concept called constant velocity update (CUPT) to correct IMU errors on a moving platform with constant velocity, such as elevators or escalators where ZUPT is infeasible. A closed-loop step-wise smoothing algorithm has also been developed to eliminate discontinuities in the trajectory caused by sharp corrections. Experimental results demonstrate the effectiveness of the proposed algorithms.
Temporal and regional variations in sporadic Creutzfeldt–Jakob disease in Japan, 2001–2010
Authors: NAKATANI E. , NISHIMURA T. , ZHOU B. , KANEDA H. , TERAMUKAI S. , NAGAI Y. , FUKUSHIMA M. , KANATANI Y.
Published: June 2014

The objective of this study was to examine temporal and regional variations of sporadic Creutzfeldt–Jakob disease (sCJD) in a retrospective study using Japanese national surveillance data from 2001 to 2010. We calculated the incidence of sCJD by age and sex, derived the standardized incidence in each of the 47 prefectures, and performed spatial disease clustering analysis. The average annual incidence of sCJD was 1·026 per million in men (637 patients) and 1·132 per million in women (733 patients), a significant sex difference after adjustment for age (P = 0·001). The ratios of familial CJD to sCJD apparently increased between 2001–2005 and 2006–2010, possibly as a result of the nationwide introduction of genetic testing after 2006. Based on the data of 2006–2010, certain geographical clusters of sCJD were identified. The incidence of sCJD was higher in several specific prefectures compared to the national average. Thus, sCJD appears to have regional variations, suggesting the existence of genetic or region-specific factors affecting the incidence of the disease.
LONG-TERM INVESTMENT AND NET-WORTH BUILDING WITH LIMITED CONTRACT ENFORCEMENT
Authors: Uras Burak R.
Published: June 2014

This paper develops a firm dynamics model augmented with an endogenous net-worth-building feature at the firm level and investigates how opportunities for entrepreneurs to accumulate wealth can mitigate the implications of limited enforceability for resource allocation, productivity, and macroeconomic development. In the steady-state equilibrium of the model, financially constrained entrepreneurs select short-term investment projects because short-term investment enhances net-worth building and relaxes credit constraints. The limited contract enforceability suppresses macroeconomic output; however, entrepreneurial net-worth building offsets the per capita income losses. I calibrate the steady state of the model for the U.S. economy as a baseline and conduct quantitative exercises. The counterfactual simulations reveal that net-worth building could reduce, for instance, about two-thirds of the per capita income discrepancy between the United States and Brazil that can be attributed to limited enforcement. The theoretical and quantitative results from the paper are highly relevant to financial development and entrepreneurship policies implemented in developing countries.
Impact of Friction Stir Welding on the Microstructure and Microtexture of Ferritic-Martensitic HT9 Steel
Authors: Brewer L.N. , Ray L.L. , Menon S.K.
Published: June 2014

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
Clinical perspective: Linking psychosocial care to the disease continuum in patients with multiple myeloma
Authors: Zabora James , Buzaglo Joanne , Kennedy Vicki , Richards Tiffany , Schapmire Tara , Zebrack Brad , Ghobrial Irene M.
Published: June 2014

Objective:

A model of psychosocial care specific for patients with multiple myeloma and their caregivers has not yet been proposed. We sought to develop a model of care that considers the specific profile of this disease.

Method:

The authors, representing a multidisciplinary care team, met in December of 2012 to identify a model of psychosocial care for patients with multiple myeloma and their caregivers. This model was determined by consensus during the meeting and via total agreement following the meeting. The meeting was sponsored by Onyx Pharmaceuticals.

Results:

The need for targeted psychosocial care for the multiple myeloma patient and caregiver throughout the disease process is essential to ensure quality of life and optimal treatment outcomes. We propose herein the first known model of care for the treatment of multiple myeloma that engages both the patient and their caregivers.

Significance of results:

Innovative partnerships between psychosocial providers and other entities such as pharmaceutical companies can maximize resources for comprehensive program development. This manuscript proposes a model of care that promotes active engagement in therapies for multiple myeloma while engaging the individual patient and their family caregivers. This treatment approach must be evidence based in terms of distress screening tools, comprehensive psychosocial assessments, and, most importantly, in the interventions and measurements of response that clinicians apply to this population.
Moral Politics: The Religious Factor in Referenda Voting
Authors: Rapp Carolin , Traunmüller Richard , Freitag Markus , Vatter Adrian
Published: June 2014

This article combines the research strands of moral politics and political behavior by focusing on the effect of individual and contextual religiosity on individual vote decisions in popular initiatives and public referenda concerning morally charged issues. We rely on a total of 13 surveys with 1,000 respondents each conducted after every referendum on moral policies in Switzerland between 1992 and 2012. Results based on cross-classified multilevel models show that religious behaving instead of nominal religious belonging plays a crucial role in decision making on moral issues. This supports the idea that the traditional confessional cleavage is replaced by a new religious cleavage that divides the religious from the secular. This newer cleavage is characterized by party alignments that extend from electoral to direct democratic voting behavior. Overall, our study lends support to previous findings drawn from American research on moral politics, direct democracies, and the public role of religion.
Sleep, Aggression, and Psychosocial Adjustment in Male Prisoners
Authors: Vogler, Shared first authorship Nicole , Perkinson-Gloor, Shared first authorship Nadine , Brand Serge , Grob Alexander , Lemola Sakari
Published: June 2014

In this study, we investigate sleep quantity and quality and their association with anger-related reactions, symptoms of ADHD, depressive symptoms, physical health complaints, and life satisfaction in male prison inmates. Furthermore, we examine whether good sleep hygiene in the prison context (physical exercise during the day, switching the television off at night, limiting caffeine and cigarette consumption) is related to sleep quantity and quality. Forty-nine prison inmates (mean age = 39.37; SD = 13.95) completed questionnaires assessing sleep quality and quantity, sleep hygiene, and psychosocial and physical functioning. Short sleep duration (6 h or less) and poor sleep quality were related to higher levels of aggressiveness in aggression-provoking social situations and more physical health complaints. In addition, poor sleep quality was related to higher levels of rumination and more symptoms of ADHD. Daily caffeine consumption, a sleep hygiene variable, was related to shorter sleep duration. The results suggest that, among a sample of male prison inmates, adequate sleep duration and good sleep quality were associated with better psychosocial adjustment.
Adoptive T‐cell therapy: adverse events and safety switches
Authors: Tey Siok‐Keen
Published: June 2014

The potential of adoptive T‐cell therapy in effecting complete and durable responses has been demonstrated in a number of malignant and infectious diseases. Ongoing progress in T‐cell engineering has given cause for optimism in the broader clinical applicability of this approach. However, the development of more potent T cells is checked by safety concerns, highlighted by the occurrence of on‐target and off‐target toxicities that, although uncommon, have been fatal on occasions. Timely pharmacological intervention is effective in the management of a majority of adverse events but adoptively transferred T cells can persist long term, along with any unwanted effects. A recently validated cellular safety switch, inducible caspase 9 (iCasp9), has the potential to mitigate the risks of T‐cell therapy by enabling the elimination of transferred T cells if required. In haematopoietic stem cell transplantation, iCasp9‐modified donor T cells can be rapidly eliminated in the event of graft‐versus‐host disease. This review presents an overview of the risks associated with modern T‐cell therapy and the development, clinical results and potential future application of the iCasp9 safety switch.
Erratum: Classification and quantification of bacteriophage taxa in human gut metagenomes
Authors: Waller Alison S , Yamada Takuji , Kristensen David M , Kultima Jens Roat , Sunagawa Shinichi , Koonin Eugene V , Bork Peer
Published: June 2014

Correction to: The ISME Journal (2014) 8, 1548–1550; doi:10.1038/ismej.2014.30; published online 13 March 2014 Since the publication of this article, the authors have identified an error in Figure 1a, namely that the columns were not clustered and the column labels were incorrect, in that 252.Gut.PFPR and 61.
Evolutionary optimality in sex differences of longevity and athletic performances
Authors: Asanuma Hiromi , Kakishima Satoshi , Ito Hiromu , Kobayashi Kazuya , Hasegawa Eisuke , Asami Takahiro , Matsuura Kenji , Roff Derek A. , Yoshimura Jin
Published: June 2014

Many sexual differences are known in human and animals. It is well known that females are superior in longevity, while males in athletic performances. Even though some sexual differences are attributed to the evolutionary tradeoff between survival and reproduction, the aforementioned sex differences are difficult to explain by this tradeoff. Here we show that the evolutionary tradeoff occurs among three components: (1) viability, (2) competitive ability and (3) reproductive effort. The sexual differences in longevity and athletic performances are attributed to the tradeoff between viability (survival) and competitive ability that belongs to the physical makeup of an individual, but not related to the tradeoff between survival and reproduction. This provides a new perspective on sex differences in human and animals: females are superior in longevity and disease recovery, while males are superior in athletic performance.
A facile strategy to prepare redox-responsive amphiphilic PEGylated prodrug with high drug loading content and low critical micelle concentration
Authors: Wang Ying , Luo Qiaojie , Gao Lilong , Gao Chen , Du Hong , Zha Guangyu , Li Xiaodong , Shen Zhiquan , Zhu Weipu
Published: June 2014

Preparation of a redox-responsive amphiphilic PEGylated prodrug with a high drug loading content and a low critical micelle concentration by polycondensation and esterification.
Transformation of β-sheet structures of the amyloid peptide induced by molecular modulators
Authors: Niu Lin , Liu Lei , Xu Meng , Cramer Jacob , Gothelf Kurt V. , Dong Mingdong , Besenbacher Flemming , Zeng Qingdao , Yang Yanlian , Wang Chen
Published: June 2014

In this work we report the controlled modulation of secondary structures of the amyloid peptide by terminus molecular modulators.
Formal [3+2] cycloaddition of 1-cyanocyclopropane 1-ester with pyridine, quinoline or isoquinoline: a general and efficient strategy for construction of cyanoindolizine skeletons
Authors: Liu Juanjuan , Zhou Lanxiang , Ye Weijian , Wang Cunde
Published: June 2014

An efficient and straightforward preparation of cyanoindolizine derivatives via a cycloaddition reaction between 1-cyanocyclopropane 1-ester and pyridine or benzopyridine.
Accumulation of supramolecular nanoparticles self-assembled from a bola-shaped cytidylic acid-appended fluorescein dye in cell nuclei
Authors: Iwaura Rika , Shirai Mutsumi , Yoshida Kaname , Ohnishi-Kameyama Mayumi
Published: June 2014

The accumulation of the supramolecular nanoparticles self-assembled from a cytidylic acid-appended dye in cell nuclei is observed without nuclear-localizing tags.
A heterodinuclear RuIr metal complex for direct imaging of rRNA in living cells
Authors: Sun Shiguo , Wang Jitao , Mu Daozhou , Wang Jingyun , Bao Yongming , Qiao Bo , Peng Xiaojun
Published: June 2014

A novel dual luminescence heterodinuclear RuIr complex for RNA detection was developed, which was successfully used to image rRNA in living cells.
Understanding composition–property relationships in Ti–Cr–V–Mo alloys for optimisation of hydrogen storage in pressurised tanks
Authors: Callear Samantha K. , Ramirez-Cuesta Anibal J. , Kamazawa Kazuya , Towata Shin-ichi , Noritake Tatsuo , Parker Stewart F. , Jones Martin O. , Sugiyama Jun , Ishikiriyama Mamoru , David William I. F.
Published: June 2014

Neutron and X-ray powder diffraction have been used together with inelastic neutron scattering and DFT calculations in order to understand how the composition of two metal alloys can be altered in order to tune their hydrogen storage properties.
Data mining with molecular design rules identifies new class of dyes for dye-sensitised solar cells
Authors: Cole Jacqueline M. , Low Kian Sing , Ozoe Hiroaki , Stathi Panagiota , Kitamura Chitoshi , Kurata Hiroyuki , Rudolf Petra , Kawase Takeshi
Published: June 2014

Big data science informs energy research: large-scale screening of crystal structures identifies unforeseen class of dyes for dye-sensitised solar cells.
High valence 3p and transition metal based MOFs
Authors: Devic Thomas , Serre Christian
Published: June 2014

This article focuses on high valence 3p and transition metal based metal organic frameworks.
Recent progress in low-voltage cathodoluminescent materials: synthesis, improvement and emission properties
Authors: Li Guogang , Lin Jun
Published: June 2014

This review is devoted to the recent progress in the synthesis and improvement of low-voltage cathodoluminescent materials for field emission displays.
Controlled synthesis of hierarchical TiO2 nanoparticles on glass fibres and their photocatalytic performance
Authors: Chen Lin , Yang Sudong , Mäder Edith , Ma Peng-Cheng
Published: June 2014

This paper reports the synthesis of novel photocatalysts consisting of TiO2 nanoparticles and glass fibres (GF) using a two-step process.
Ultrafinely dispersed Pd nanoparticles on a CN@MgO hybrid as a bifunctional catalyst for upgrading bioderived compounds
Authors: Li Mingming , Xu Xuan , Gong Yutong , Wei Zhongzhe , Hou Zhaoyin , Li Haoran , Wang Yong
Published: June 2014

A bifunctional catalyst Pd/CN@MgO showed excellent catalytic activity in the above tandem reaction, achieving full conversion and good product selectivity.
Time lapse investigation of antibiotic susceptibility using a microfluidic linear gradient 3D culture device
Authors: Hou Zining , An Yu , Hjort Karin , Hjort Klas , Sandegren Linus , Wu Zhigang
Published: June 2014

Time lapse antibiotic susceptibility investigation.
A photo- and halochromic multicolor switching system consisting of diarylethene and malachite green moieties
Authors: Tatsumi Yuto , Fujinaga Noriko , Kasuno Megumi , Morimoto Masakazu , Yokojima Satoshi , Nakamura Shinichiro , Uchida Kingo
Published: June 2014

A diarylethene with a malachite green moiety was synthesized, and it showed multicolor states by photochromic and halochromic reactions.
DNA-controlled aggregation of virus like particles – mimicking a tetherin-like mechanism
Authors: Serien Daniela , Grimm Christiane , Liebscher Jürgen , Herrmann Andreas , Arbuzova Anna
Published: June 2014

Lipophilic DNA with two α-tocopherol anchors, mimicking tetherin, a cell protein reducing spreading of viruses, induces aggregation of virus-like particles.
The facile coupling of carbon monochalcogenides to ethenedichalcogenone ligands in binuclear iron carbonyl derivatives: a theoretical study
Authors: Zhang Zhong , Pu Liang , Li Qian-shu , King R. Bruce
Published: June 2014

The lowest energy Fe2(CO)n(CE)2 structures (E = S, Se, Te; n = 7, 6) do not have separate CE ligands but instead have coupled C2E2 ligands functioning as four to six-electron donors to the pair of iron atoms.
Hierarchically porous N–F codoped TiO2 hollow spheres prepared via an in situ bubbling method for dye-sensitized solar cells
Authors: Lei Bing-Xin , Zeng Li-Li , Zhang Ping , Zheng Xiao-Feng , Wu Yan-Shan , Fu Jun , Sun Zhen-Fan
Published: June 2014

Hierarchically porous N–F codoped TiO2 hollow spheres were prepared via an in situ bubbling method for solar energy conversion application.
A simple method for efficient synthesis of tetrapyridyl-porphyrin using Adler method in acidic ionic liquids
Authors: Kitaoka Satoshi , Nobuoka Kaoru , Ihara Keita , Ishikawa Yuichi
Published: June 2014

The TPyP synthesis methodology using acidic ionic liquids can remove the ionic liquids from TPyP by easy filtration in contrast to the traditional Adler method.
Size-controlled PdO/graphene oxides and their reduction products with high catalytic activity
Authors: Lin Jingjing , Mei Tao , Lv Meijiao , Zhang Chang'an , Zhao Zhenfeng , Wang Xianbao
Published: June 2014

Well-dispersed and size-controlled Pd/RGO with highly active catalysts was synthesized through reduction of PdO/GO with hydrazine hydrate and ammonia. The electrocatalytic activity and the stability of the as-prepared Pd/RGO are much better than those of commercial Pd/C catalysts for methanol electrooxidation and the Suzuki reaction.
Supramolecular assemblies of semiconductor quantum dots and a bis(bipyridinium) derivative: luminescence quenching and aggregation phenomena
Authors: Oszajca Marek , Lincheneau Christophe , Amelia Matteo , Baroncini Massimo , Silvi Serena , Szaciłowski Konrad , Credi Alberto
Published: June 2014

CdSe and CdSe–ZnS nanocrystal aggregates are formed in solution in the presence of a bis(bipyridinium) species, and disrupted upon addition of a macrocyclic host.
Uniform core–shell molecularly imprinted polymers: a correlation study between shell thickness and binding capacity
Authors: Zhang Zhong , Chen Lingxin , Yang Fangfang , Li Jinhua
Published: June 2014

A model of core–shell MIPs was constructed to evaluate the correlation between shell thickness and binding capacity.
Insufficient oxygen diffusion leads to distortions of microbial growth parameters assessed by isothermal microcalorimetry
Authors: Maskow Thomas , Morais Frida Mariana , Rosa Luis F. M. , Qian Yi G. , Harnisch Falk
Published: June 2014

Oxygen limitation is an important, but often underestimated effect influencing microbial growth parameters derived from calorimetric routine measurements.
Carbon-protected Au nanoparticles supported on mesoporous TiO2 for catalytic reduction of p-nitrophenol
Authors: Ji Tuo , Li Licheng , Wang Meng , Yang Zhuhong , Lu Xiaohua
Published: June 2014

With the introduction of carbon on Au/TiO2, the reaction rate of C/Au/TiO2 increased by 29% and the stability enhanced by about 3 times more than Au/TiO2 in the p-nitrophenol reduction reaction. Carbon species enhanced the stability of Au nanoparticles and also increase the organic reactants adsorptive ability.
Enhanced thermoelectric performance of a new half-Heusler derivative Zr9Ni7Sn8 bulk nanocomposite: enhanced electrical conductivity and low thermal conductivity
Authors: Misra D. K. , Bhardwaj A. , Singh Sanjay
Published: June 2014

Varying the valence electron concentration per unit cell (VEC) in a half-Heusler (HH) material gives a large number of structures and substructures that can be exploited to improve the thermoelectric performance.
Adaptive kinetic Monte Carlo simulation of solid oxide fuel cell components
Authors: Gunn David S. D. , Allan Neil L. , Purton John A.
Published: June 2014

Millisecond length simulations have been performed to directly calculate accurate ionic conductivities in solid oxide fuel cell (SOFC) electrolyte and cathode materials using adaptive kinetic Monte Carlo (aKMC).
The efficient separation of surfactant-stabilized oil–water emulsions with a flexible and superhydrophilic graphene–TiO2composite membrane
Authors: Gao Peng , Liu Zhaoyang , Sun Darren Delai , Ng Wun Jern
Published: June 2014

It is a worldwide challenge to efficiently separate surfactant-stabilized oil–water emulsions.
Tetragonal vs. cubic phase stability in Al – free Ta doped Li7La3Zr2O12 (LLZO)
Authors: Thompson Travis , Wolfenstine Jeff , Allen Jan L. , Johannes Michelle , Huq Ashfia , David Isabel N. , Sakamoto Jeff
Published: June 2014

X-ray and neutron diffraction, Raman spectroscopy, complex impedance spectroscopy and electron microscopy were used to characterize the tetragonal vs. cubic phase stability in superionic conducting garnet-oxide electrolyte.
Ce-/S-codoped TiO2/Sulfonated graphene for photocatalytic degradation of organic dyes
Authors: Fan Yingying , Han Dongxue , Cai Bin , Ma Weiguang , Javed Mohsin , Gan Shiyu , Wu Tongshun , Siddiq M. , Dong Xiandui , Niu Li
Published: June 2014

An improved photocatalytic performance of Ce/S–TiO2/SGE based on the synergistic effects of Ce- and S-codoping and the composite action between TiO2 NPs and SGE.
A highly efficient warm white light-emitting Eu2+-activated silicate host: another striking application of mesoporous silica
Authors: Gandhi Sakthivel , Thandavan Kavitha , Kwon Bong-Joon , Woo Hyun-Joo , Kim Chang Hae , Yi SoungSoo , Jeong Jung Hyun , Shin Dong-Soo , Jang Kiwan
Published: June 2014

The inception of a new silicate source namely mesoporous silica for the synthesis of Sr0.975Ca0.975Eu0.05SiO4phosphor shows an excellent emissive property along with the suffice red spectral components.
The combined effects of fluorine and arsenic on renal function in a Chinese population
Authors: Zeng Qi-bing , Xu Yu-yan , Yu Xian , Yang Jun , Hong Feng , Zhang Ai-hua
Published: June 2014

Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. The results clearly show that the combined effect of fluoride and arsenic on renal function is mainly antagonism at these exposure levels.
Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile
Authors: Díaz-Sáez Laura , Srikannathasan Velupillai , Zoltner Martin , Hunter William N.
Published: June 2014

Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and prokaryotes. In the present study, we characterize the catalytic properties and present the crystal structures of three bacterial kynurenine formamidases. The structures reveal a new amidase protein fold, a highly organized and distinctive binuclear Zn2+ catalytic centre in a confined, hydrophobic and relatively rigid active site. The structure of a complex with 2-aminoacetophenone delineates aspects of molecular recognition extending to the observation that the substrate itself may be conformationally restricted to assist binding in the confined space of the active site and for subsequent processing. The cations occupy a crowded environment, and, unlike most Zn2+-dependent enzymes, there is little scope to increase co-ordination number during catalysis. We propose that the presence of a bridging water/hydroxide ligand in conjunction with the placement of an active site histidine supports a distinctive amidation mechanism.