bluuebunny/crossref_metadata_2025 huggingface dataset:
Development Trends of Private Investors’ Portfolio Investment Market in the Russian Federation
Authors: Trufanova Anastasiya , Kalacheva Irina , Tihonova Alina
Published: August 2023

Political and economic uncertainty affects the population’s capability to save and invest funds, partially determines their goals. The authors explore different aspects of modern investment. The purpose is to determine the trends of the portfolio investment market development in the Russian Federation to form a behavior model of a private investor in modern economic conditions. The researchers studied the portfolio investment market development in 2019–2021, identified the main reasons for the increased popularity of investment, examined some trends in the portfolio investment market, and studied the dynamics of the brokerage services clients’ number and the number of trust management accounts. The dynamics and causes of changes in the private investors’ individual investment accounts number and their structure are considered. The volume of exchange transactions carried out by professional participants in various markets has been studied, the impact of panic and certain periods of volatility on investor behavior has been determined. Research shows that the mass entry of private investors into the stock market is influenced by the marketing component of brokers’ activities in attracting new clients.
The Sehat Ghar: An Innovation to Improve Primary Healthcare in Rural Punjab
Authors: Bhatti Muhammad Ajmal , Azhar Muhammad Asad , Hassan Zohaib , Agha Muhammad Ammar , Fahad Qadir Bukhari Syed , Aftab Wajdan
Published: August 2023

An effective healthcare sector essentially relies on a strong primary healthcare system. The primary healthcare system governs all major aspects of preventive healthcare and family planning services including immunization, hygiene, communicable disease prevention, sanitation, etc. In addition to this, a major bottleneck limiting the quality of healthcare at secondary and tertiary health facilities is the very high patient footfall that these hospitals. The primary healthcare facilities are designed to be the first tier of facility that a patient falls onto, and hence is either treated there or referred to higher level facilities by screening and limiting patient flow to next levels. Supporting this tier hence helps reduce burden on secondary and tertiary facilities of patients that could have been treated at primary facilities and hence exponentially improve the quality of health services in these lager hospitals. The document discusses some of the major issues faced by the primary healthcare sector in Punjab. These issues were studied and analyzed in detail at South Punjab Health Department, which is an arm of the provincial health department governing 11 districts of Southern Punjab – districts where socio-economic conditions are generally much poorer than the rest of Punjab. This document discusses the initiative of Sehat Ghar, its model, potential to ensure basic health services delivery to the local population and its direct & indirect contribution to tackle major issues of primary healthcare in Punjab.
Satisfaction and Self-Confidence of Undergraduate Nursing Students with Simulation-Based Learning Experiences
Authors: Iram Mamoona , Rizvi Naghma , Ilyas Nazia , Siaty Eunice , Nazar Afshan , Kurji Zohra
Published: August 2023

Background: Hands-on patient care could be best experienced through clinical rotations; however, opportunities for direct patient care for student nurses are limited due to lack of clinical sites and availability of patients, faculty shortages, and some ethical and safety concerns. The purpose to measure the satisfaction and self-confidence of nursing students with their simulation-based learning.
Methodology: This study used an analytic cross-sectional design. The study was conducted at a private university in Karachi, Pakistan, and recruited 230 nursing students using a total population sampling technique. A self-reporting questionnaire was used to collect data. ANOVA was used to see the differences in the mean scores, and Pearson correlation was used to assess the correlation between satisfaction and self confidence. Results: The overall mean + SD of satisfaction was 75.80 + 8.93 and for self-confidence was 32.59 + 3.61.
Findings revealed a significant difference in mean scores of satisfaction and self-confidence among the study groups, p < 0.05. A strong positive correlation, Pearson r = 0.725, p = 0.001, was revealed between the satisfaction and self-confidence. Conclusion: The study discovered that simulation-based learning plays a significant role in increasing satisfaction and in building the self-confidence of nursing students, so it should be made a part of their curriculum, and integrated into all possible courses in the undergraduate nursing programs.
Risk Factors Associated with Non-Communicable Diseases: Trends and Policy Implications in Nepal
Authors: Dixita Lonim , Khurshid Hyder M , Tarin Ehsanullah
Published: August 2023

Objective: To determine the trends in the prevalence of non-communicable diseases associated risk factors and implications for policies and strategies. Background: Non-Communicable Diseases (NCDs) contribute increasingly to disease burden in Nepal. The main drivers to this situation are the NCD related risk factors; and to determine their prevalence the Nepal Ministry of Health and Population conducted WHO Stepwise Approach to NCD Risk Factor Surveillance (STEPS) surveys in 2007, 2012 and 2019. This paper, by using results of STEPS surveys, explores the trends of NCD related risk factors and their implications for policies and strategies. Methods: This paper relies on the desk review of literature and secondary data, collected from the unpublished grey literature, mainly reports of the STEPS surveys. In addition, to corroborate findings, the evidence and experience from other countries available as published literature was brought. The data were analysed manually. Findings: Overall, during the period from first survey in 2007 to the last survey in 2019, there has been an
increasing prevalence of NCDs associated lifestyle and behavioural, physical, and biochemical risk factors. Taking cognisance of these, several policies, and strategic documents, some of which generic, while others targeting the specific risk factors were produced. However, indicators and techniques used, across three STEPS surveys, were not consistent, thus limiting the comparison and analysis of data.
Conclusions: The study concludes that different STEPS surveys did not use standard set of indicators and techniques. Yet, an increased prevalence of NCDs associated risk factors was noted. Several policies and strategic documents, generic as well as specific, were produced. But there is a need to define methodology, as to how results feed into the framing of policies and strategic, and their impact is monitored.
Relationship Between Water, Sanitation, Climate Change, and COVID-19
Authors: Khalid Nabiha
Published: August 2023

Climate change is the utmost crucial challenge of the 21st century with the significant potential to cause human and economic damage. COVID-19 is a global public health emergency that has caused millions of deaths worldwide.1 Studies reported that thorough sanitation practices, safe and clean water, and proper hygiene services are considered the crucial part of protecting the health of humans during the infectious disease outbreaks such as the global COVID-19 outbreak.2
Relationship Between Social Support, Social Media Usage, and Psychological Well- Being among Undergraduates in Different Institutions of Punjab
Authors: Tariq Hamza , Bilqees Umme , Fatima Seemal , Mukhtar Sumbal , Usman Hafiz , Ahmad Butt Amad Noor
Published: August 2023

Background: Social media is like a magnanimous tree and us being leaves connected through twigs of imagination Today 4.33 billion people are connected to the internet, and almost all do by using their mobiles. In Pakistan, there were 71 million broadband subscribers and 69 million 3G/4G users in June 2019.
Aims & Objectives: The current study aimed to find the relationship between social support, social media usage, and psychological well-being among undergraduates aged 18-25 years. Methods: A sample of eight hundred and forty-three male and female students was included in this research. A stratified random sampling technique was applied in the research. The sample was taken from departments of various institutions in Lahore. The duration of the study was 6 months. The study was a cross-sectional study and the data were collected using questionnaires based on Ryff's scale of psychological well-being, Media and Technology Usage and Attitudes Scale, and Inventory of Social Supportive Behavior (ISSB) scale. Results: The data were analyzed on SPSS 25 and the results indicated that social support received from close ties was positively correlated with psychological well-being [r(841) = .523, n = 843, p< .001]. At the same time, social support received from online sources had no significant impact on psychological well-being while social media usage was negatively correlated with psychological well-being [r(841) = -.215, n = 843, p< .001]. Using the regression analysis technique, the three variables in combination explained 34.6% of the variance in psychological well-being [R2 = 0.346, F(6, 836) = 75.37, p< 0.01]. Age and gender had no significant effect. Conclusion: These findings implicate that healthy interpersonal relationships between close ties and
undergraduate students should be encouraged and controlled usage of social networking sites should be practiced.
Semitendinosus Tendon Graft for Hand Tendon Reconstruction
Authors: Tahir Hassan , Beg Shehab Afzal
Published: August 2023

Background: Hand tendon reconstruction is required in both acute and chronic tendon injuries. A number of donor sites have been described; one such novel donor site is semitendinosus tendon used a graft for hand tendon reconstruction. Based on data reviewed, only a few cases are described up till now. Methods: Semitendinosus tendon was utilized in total of 18 patients undergoing tendon reconstruction for chronic tendon injuries and for tendon transfer to achieve adequate length. All cases were performed during
January 2019 To December 2020. Full length uni/bilateral semitendinosus tendon was harvested using a tendon harvester. Tendon was used as a single slip or was split into further slips as needed for tendon reconstruction. Post operatively splints were continued as per protocol (keeping splint for 6 weeks, encouraging active physiotherapy at 8 weeks, continuing night splint age for total of 10 weeks and advising patient to avoid lifting heavy weight for at least 12 weeks). Patients were followed with assessment of strength via MRC (Medical
Research Council) grading scale, and tendon excursion measurements via tip to palm distance. Results: Patients had a mean age for 27.5±2.3 with a predominant male population (72.2%). Post-operative assessment showed finger strength of MRC 5 in twelve patients and MRC 4 in three and MRC 3 in three patients. Tendon excursion was documented measuring a tip to palm distance. Three patients developed tendon adhesions which were treated with tenolysis. Conclusion: Semitendinosus is a recommended option for hand tendon (both flexor & extensor) reconstruction, providing adequate length & strength for reconstruction with high predictable availability and reliability. Although Palmaris longus remains the recommended option for single tendon reconstruction, it is absent in a few cases or is rudimentary, making it difficult to be utilized.
Transverse and Sigmoid Venous Thrombosis Presenting as Proptosis and Acute Loss of Vision: An Unreported Association
Authors: Malik Uzma , Munir Samavia , Mukhtar Muhammad Umer , Kamal Zahid , Iftikhar Sadaf
Published: August 2023

Cerebral venous sinus thrombosis is a rare disorder characterized by thrombosis in the venous channels of the brain. Nonspecific symptoms such as headache, focal neurologic deficits and seizures make this condition difficult to diagnose. We describe a case of cerebral venous thrombosis in the sigmoid and transverse sinuses which presented as reversible, rapid-onset proptosis and loss of vision in a patient of subclinical hypothyroidism. Such an occurrence of proptosis due to thrombosis of the sigmoid and transverse sinuses has never been reported in literature. The diagnosis of cerebral venous thrombosis in this patient was arrived at in a stepwise fashion.
Thus, this case in addition to reporting a novel finding, stresses by example, the importance of acute suspicion on part of the physician for timely diagnosis and treatment of this eluding yet reversible disease.
Fear of Missing Out in University Students: A Psychometric Study
Authors: Sabir Amna Saba , Jabeen Ayesha
Published: August 2023

Background:
Fear of missing out is a subcategory of social anxiety and an upsurge issue which may lead university students to experience many detrimental effects on their well-being.
Objective:
To develop an indigenous scale with sound psychometric properties to measure fear of missing out by highlighting the culture-specific experiences of university students.
Method:
A mixed cross-sectional research design was used. This study was carried out from October 2020 to May 2021. Data was collected from different government and private universities in Lahore. Initially, 82 items were generated by conducting interviews with university students. After eliminating dubious items, a list of 57 items was generated. These items were given to a committee of experts for empirical validation. After that, a list of 48 items was finalized. Then these items were piloted on 14 university students. Finally, this scale along with the demographic form was administered to a sample of 400 university students (men=194, women=206) in the age range of 18 to 28 years (M=21, SD=2.15) using purposive sampling technique.
Results:
Exploratory Factor Analysis revealed four-factor structures of fear of missing out scale named, Low Self-Esteem, Lack of Contentment, Apprehensions, and Jealousy. In each subscale, no. of items ranges from 6 to 14 items. Results revealed the newly developed scale has a high internal consistency of a=.73, test-retest reliability r=.89, and good concurrent validity r= .34. Results also revealed that 14.0% of participants have mild, 37.3% have moderate, 32.0% have severe and 16.8% have a very severe level of fear of missing out.
Conclusion:
As a result of this study a 41-items self-reported measure of fear of missing out for university students, having sound psychometric properties was developed.
Leadership in Undergraduate Medical Education: A Study of Pakistani Medical Students’ Perceptions, Attitudes, and Interest
Authors: Imran Nazish , Khalid Bakhtawar , Afzal Zubia , Azeem Saleha , Fatima Osheen , Haider Imran Ijaz , Azeem Muhammad Waqar , Javed Afzal
Published: August 2023

Background: Despite calls for the much-needed involvement of physicians in leadership, very few medical colleges in Pakistan provide explicit training on the knowledge, skills, and attitudes necessary to be an effective physician leader.
Objective: To explored Pakistani medical students’ perceptions, attitudes, and interests regarding Leadership training in medical education.
Methods:
Participants were asked about their perceptions and attitudes towards medical leadership on a 5-point Likert scale. Students also self-rated their leadership competencies noted as per Medical Leadership Competency Framework. Survey also assessed the perceived need and topics for a leadership curriculum for physician leaders, the teaching format, and barriers to leadership training in medical schools. Data were analyzed using SPSS 26.
Results:
60.6% of the total 1204 respondents rated their leadership training in medical college as “very poor” or “poor” and 80.3% of them endorsed their interest and need for it. 77.4% of the participants agreed that clinicians should influence leadership decisions in a clinical setting. Only 25% of respondents were aware of the demands of a leadership rank in medicine. Leadership competencies endorsed for training included problem-solving, leading a team, confronting problematic employees, and communication skills with a multimodal teaching approach, including teaching methods like small group discussions. The main barriers to leadership training were identified as time constraints (66.1%), lack of available curriculum (69.0%), and disinterest by faculty (67.0%).
Conclusion:
Our study suggests that medical students in Pakistan appreciate the importance of leadership training in undergraduate education. There is a need for dedicated leadership teaching and study data to specify the possible content and delivery methods to serve as goals for an undergraduate leadership curriculum in Pakistan.
THE ROAD LESS TRAVELED: NURTURING A MEDICAL JOURNAL'S QUEST FOR INTERNATIONAL INDEXATION AND IMPACT FACTOR
Authors: Sherin Akhtar
Published: August 2023

Journal Impact Factor (JIF), proposed by Eugene Garfield in early 1960s, is considered as the one of the most widely recognized and influential metrics for scholarly journal ranking in the world. It provided a standardized measure based on the citation data for evaluation of journals. In 1975, the Institute for Scientific Information introduced the initial version of the Journal Citation Reports (JCR) as an essential part of the Science Citation Index, spearheaded by Eugene Garfield. First JCR was based on 4,248,065 citations of around 400,OOO source items published during 1974 in 2400 journals.1 Since then, JCR & JIF have undergone significant developments and transformations. They became widely adopted tools for evaluating research impact and journal prestige. Over the years, the IF and JCR expanded their coverage, incorporating more journals and disciplines. Recently released JCR 2023 comprised of 21,522 journals (including 13,668 science journals) from 112 countries across 254 research disciplines.2
Prevalence of Emotional Intelligence in Students at a Medical College in Pakistan
Authors: Chaudhry Muhammad Ashraf , Rafeeq Shireen , Khan Daniyal Asim , Nosheen Javaria , Munir Shahid
Published: August 2023

Background: Traditional thinking places high Intelligence Quotient (IQ) as the most important predictor of success but its contribution is only half that of Emotional Intelligence (EI), the ability to manage emotions. EI encompasses several skills, all of which need to be mastered for professional and personal success.
Objectives: To determine the emotional intelligence level of medical students at a private medical college in Lahore, Pakistan, and to see its association with gender and years of study.
Methods: This cross-sectional study was conducted between January and March 2022. Convenience Sampling was used to select 370 medical students at a private college in Lahore, Pakistan, who filled out a questionnaire to measure their emotional intelligence. SPSS 20 was used for data analysis.
Results: The majority scored in the middle range of EI, with a mean score of 58.6±7.8 (out of a possible lowest score of 20 and highest of 80). There was a significant association of EI with gender as well as with years of study. Males had higher total EI scores than females (p.002), as well as higher mean EI score of 59.9±8 compared to 56.9±7.3 for females (p.001). Students from higher classes had higher total scores as well as higher mean scores than those from lower classes (p.001) and (p.001) respectively.
Conclusions: Half the respondents got mid-range EI scores. While there were very few low scores, only a third scored in the desirable higher ranges indicating a need for counselling.
Determination of Multidrug Resistance and Extended Drug Resistance Pattern of Pseudomonas aeruginosa in Clinical Isolates of Tertiary Care Hospital Lahore
Authors: Ahmed Dilshad , Javed Hasnain , Kanwal Wajiha , Fatima Warda , Qadir Nida Abdul
Published: August 2023

Background:
Pseudomonas aeruginosa (PA) is a major public health community-acquired threat around the globe due to the growing rate of antimicrobial resistance. It is one of the most common trending causes of nosocomial infections.
Objective:
The current study aimed to check the rate of multidrug-resistant (MDR) and extended drug-resistant (XDR) PA and to analyze the invitro activity of different antimicrobial agents against clinically isolated bacterial samples. Molecular Detection and amplification of L lipoprotein (OprL gene) were also done to determine the frequency and species of different strains of Pseudomonas aeruginosa (PA2192, C3719, PA01, PA14 and PACS2).
Method:
This cross-sectional study was conducted at at the Department of Pathology, King Edward Medical University/ Mayo Hospital Lahore. Total 140 patients were included in the study. Biochemical characterization, molecular identification, antimicrobial susceptibility profiling and DNA sequencing of the desired gene were done to confirm different strains' identification.
Results:
MDR and XDR Pseudomonas aeruginosa infection are more common among males 81(57.5%) and high among the 31-45 age group, i.e., 55 (39.3%). After antibiotic susceptibility testing, 60% of strains were found to be MDR PA, while 40% were categorized as XDR PA. Doripenem showed the highest sensitivity, 93 (66.4%) among all carbapenems. Polymyxin B showed the highest activity against Pseudomonas aeruginosa multi and extensively drug-resistant strains, i.e., 108 (77.1%).
Conclusion:
The present study suggests that doripenem can be the only active agent for combating infections, and the Carbapenem drug appears effective against highly resistant strains of Pseudomonas aeruginosa.
Spatio-temporal variation of annual precipitation in China and its response to ENSO
Authors: Chen Yang , Ma Long , Liu Tingxi , Huang Xing , Sun Guohua
Published: August 2023

The results showed that the precipitation in the study area was mainly in a downward trend before the mid-1930s, and then turned upward. In the 1950s, the precipitation generally showed a distribution of rising in the west and falling in the east, and this trend continued until the early 21st century. By 2007, except for the central part of the Continental Basin, the overall trend was mainly upward. In this study, 65 El Niño Southern Oscillation (ENSO) events were identified, including 24 El Niño events and 41 La Niña events. The precipitation was generally less when ENSO occurred. However, there were differences in the type and intensity of the event. For example, El Niño had a greater impact on precipitation than La Niña did, and extremely strong or strong El Niño/La Niña events had a more significant impact than moderate, weak, or extremely weak ones. The correlation between precipitation and El Niño or La Niña events had some similarities and differences. For example, precipitation was mainly negatively correlated with El Niño and La Niña at the same time, and both correlations were proportional to intensity, but the correlation between precipitation and El Niño was significantly stronger than that of La Niña.
Recent advances in heavy metal removal by thin film nanocomposite membrane
Authors: Mohamad Aummil Nadira , Aziz Farhana , Yusof Norhaniza , Jaafar Juhana , Wan Salleh Wan Norharyati , Jye Lau Woei , Ismail Ahmad Fauzi
Published: August 2023

Rapid industrialization has become one of the root causes of environmental problems, particularly heavy metal pollution. Numerous methods, including chemical precipitation and ion exchange, have been used to remove heavy metal ions from aqueous solutions, but all of them have drawbacks, such as low metal removal effectiveness, significant reagent loss, excessive energy use, and the need for further development of the current techniques. Membrane-based technologies such as reverse osmosis (RO) and nanofiltration (NF) are gaining popularity in the removal of heavy metals due to their high rejection and low formation of secondary pollutants. Among the methods under consideration, the membrane-based approach holds the most promise for wastewater treatment with a focus on heavy metal ion removal due to its ease of manufacture, superior qualities, and increased separation effectiveness. Since membrane performance is typically hampered by fouling, low permeability, and significant contaminant permeation when compared to strict selectivity criteria, the development of novel membrane materials has emerged as an important area of research for academia, industry, and national laboratories. We have therefore reviewed previous initiatives and technological developments in order to achieve more effective heavy metal removal and recovery from industrial wastewater.
Sistemas de recomendação em bibliotecas
Authors: De Moura Vieira Bruna Beatriz , Passos Ketry Gorete Farias dos , Salm Vanessa Marie
Published: August 2023

Sistemas de recomendação são ferramentas de software que têm como objetivo gerar uma estimativa da utilidade que um item pode ter para um usuário, bem como analisar interações entre usuários e itens. São divididos entre sistemas de recomendação clássicos, que utilizam apenas um tipo de técnica de filtragem, e híbridos, que utilizam dois ou mais tipos de técnicas de filtragem aliados a uma técnica de recomendação híbrida. O objetivo deste artigo consiste em apresentar os sistemas de recomendação em bibliotecas e propor um modelo de recomendação híbrido teórico, adaptado ao contexto das bibliotecas. Para isto, foi utilizada uma abordagem qualitativa, exploratória, descritiva e bibliográfica para explorar o tema de sistemas de recomendação e sua aplicação em bibliotecas como uma resposta às crescentes demandas informacionais dos usuários. Foi percebido que a maioria das iniciativas de sistemas de recomendação em  uso atualmente são do modelo clássico, e utilizam apenas dois tipos de filtragem – por conteúdo e colaborativa. Portanto, é necessário que pesquisas futuras tentem entender o motivo por trás da adoção dos sistemas de recomendação do modelo clássico em detrimento dos sistemas de recomendação híbridos, e que é necessário um maior enfoque no desenvolvimento e aplicação de sistemas de recomendação híbridos em bibliotecas, dado às suas vantagens em relação ao modelo clássico. Também é sugerida a realização de estudos sobre as outras diferentes técnicas de filtragem, pelo fato de possuírem o potencial de gerar novos tipos de estratégias de recomendação em bibliotecas.
Clinicopathological Characteristics, Prognosis, and Correlated Tumor Cell
Function of Tropomodulin-3 in Pancreatic Adenocarcinoma
Authors: Zhong Bin , Ma Dan-Dan , Zhang Tao , Gong Qi , Dong Yi , Zhang Jian-Xin , Li Zhong-Hu , Jin Wei-Dong
Published: August 2023

Background:

Pancreatic adenocarcinoma (PAAD) is a frequent malignant tumor with a
high mortality rate. Searching for novel biomarkers that can influence its prognosis may help patients.
It has been shown that tropomodulin-3 (TMOD3) may influence tumor progression, but its
role in pancreatic cancer is not clear. We aimed to explore the expression and prognostic value of
TMOD3 in PAAD.

Methods:

We used bioinformatics analysis to analyze the relationship between TMOD3 expression
and clinicopathological features and prognosis and verified it with clinical data from tissue microarray.
We also conducted in vitro cell experiments to explore the effects of TMOD3 on the function
of PAAD cells.

Results:

TMOD3 expression was found to be significantly higher in PAAD tissues than in matched
paracancerous tissues (P < 0.05). Meanwhile, high TMOD3 expression was associated with significantly
poorer overall survival (P < 0.05). Analysis of relevant clinicopathological characteristics
data obtained from TCGA showed that high TMOD3 expression correlated with age, TNM stage,
N stage, and M stage (P < 0.05). Analysis of correlation data obtained from tissue microarrays
showed that high TMOD3 expression was associated with lymph node invasion, nerve invasion,
macrovascular invasion, and TNM stage (P < 0.05). In addition, siRNA knockdown of TMOD3
significantly reduced the migration and invasion of PAAD cells.

Conclusion:

Our study shows that TMOD3 may be associated with the progression of PAAD
cells, and that it is an independent risk factor for poor pathological features and prognosis of
PAAD. It may be helpful as a prognostic indicator of clinical outcomes in PAAD patients.
Reduced Level of Prolylhydroxyproline in the Nail Clippings of Oral Cancer
Patients and its Role as an Activator of Phospholipase C-β2
Authors: Bhatkar Devyani , Nimburkar Dipti , Raj Ajay Kumar , Lokhande Kiran B. , Khunteta Kratika , Kothari Haet , Joshi Mrudula , Sarode Sachin C. , Sharma Nilesh Kumar
Published: August 2023

Background:

The oral cancer microenvironment plays an important role in the development
and progression of the disease which depicts the heterogeneous nature of diseases. Several
cellular and non-cellular factors, including dipeptides, have been reported to drive tumor progression
and metastasis. Among various secreted molecules in the tumor microenvironment, prolylhydroxyproline
(Pro-Hyp) is a collagen-degraded product with specific relevance to fibrosis and oral
cancer. However, the detection of Pro-Hyp in the nails of oral cancer patients is a potential biomarker,
and our understanding of the biological relevance of Pro-Hyp is highly limited.

Methods:

Here, the authors have attempted to use a novel and in-house vertical tube gel electrophoresis
(VTGE) protocol to evaluate the level of Pro-Hyp in the nails of oral cancer patients
and healthy subjects. Furthermore, we employed molecular docking and molecular dynamics (MD)
simulations to predict the biological function of Pro-Hyp. ADME profiles such as the druglikeness
and leadlikeness of Pro-Hyp and a known PLC-β2 activator, m-3M3FBS, were evaluated by the
SWISS-ADME server.

Results:

We report that among various key metabolites, Pro-Hyp, a dipeptide, is reduced in the
nails of oral cancer patients. Molecular docking and MD simulations helped to suggest the potential
role of Pro-Hyp as an activator of Phospholipase C-β2 (PLC-β2). Pro-Hyp displayed good binding
affinity (-7.6 kcal/mol) with specific interactions by a conventional hydrogen bond with key
residues, such as HIS311, HIS312, VAL641, and GLU743. MD simulations showed that the activator
binding residues and stability of complexes are similar to the well-known activator m-3M3FBS
of PLC-β2. ADME profiles such as the druglikeness and leadlikeness of Pro-Hyp were found to be
highly comparable and even better than those of m-3M3FBS.

Conclusion:

This study is one of the first reports on Pro-Hyp as a metabolite biomarker in the nails
of oral cancer patients. Furthermore, the implications of Pro-Hyp are proposed to activate PLC-β2
as a pro-tumor signaling cascade. In the future, diagnostic and therapeutic approaches may be explored
as biomarkers and mimetic of Pro-Hyp.
How to Modulate Peripheral and Central Nervous System to Treat Acute
Postoperative Pain and Prevent Pain Persistence
Authors: Cazzaniga Sara , Real Giovanni , Finazzi Simone , Lorini Luca F. , Forget Patrice , Bugada Dario
Published: August 2023

Chronic postoperative pain (CPSP) is a major issue after surgery, which may impact on patient’s
quality of life. Traditionally, CPSP is believed to rely on maladaptive hyperalgesia and risk factors
have been identified that predispose to CPSP, including acute postoperative pain. Despite new
models of prediction are emerging, acute pain is still a modifiable factor that can be challenged with
perioperative analgesic strategies. In this review we present the issue of CPSP, focusing on molecular
mechanism underlying the development of acute and chronic hyperalgesia. Also, we focus on how
perioperative strategies can impact directly or indirectly (by reducing postoperative pain intensity) on
the development of CPSP.
The Evaluation of Subcutaneous and Visceral Adipose Tissue Changes by
Computed Tomography in Coronavirus Disease 2019 and Comparison with
Quantitative Analysis of Lung Involvement
Authors: Vural Murat , Akdal Dolek Betul , Ucar Ozgul , Ozkan Erdem , Eren Ozkaya Utku
Published: August 2023

Background:

This study aims to reveal the relationship between lung involvement and visceral adipose tissue changes between chest-computed tomography (CT) scans taken in short intervals in COVID-19 patients.

Methods:

The retrospective study included 52 patients who tested positive for SARS-CoV-2. All patients had two chest CT exams. Lung involvement measurements were calculated by using an artificial intelligence tool. Visceral and subcutaneous fat tissue was measured at the level of the first lumbar vertebra on chest CT. Additionally, demographic and laboratory data were collected.

Results:

52 patients were included (36.5 % female, mean age 50). Visceral fat area and visceral fat thickness changes were significantly positive predictors of total lung involvement changes (p=0.033, p=0.00024). Subcutaneous fat area and subcutaneous fat thickness changes were not associated with lung involvement change (p>0.05). CRP, IL-6, d-dimer, and ferritin levels were higher in patients who need intensive care units.

Conclusion:

Visceral adipose tissue changes may indicate that it can have a role as a reservoir of virus involvement.
Fingertip injury: A case report in emergency departments
Authors: Anwar Saeful
Published: August 2023

Fingertip injury is one of the most common injuries to the hand. Injuries can include damage to the skin and soft tissue, bones (distal phalanx), nails and nailbed. The fingertips are rich in nerves and very sensitive. Without prompt and precise treatment, finger injuries can interfere with the complex function of the hand and may result in permanent deformity and disability. This report aims to report management in patients with fingertip injury. A 25-year- male patient with fingertip injury in the area of the right index finger. The results of the localis status examination found a laceration measuring 3x1,5 cm with uneved edges in aspectus volar in the distal phalanx in the II digit along with tenderness and no limited finger movement. Patients treated with pharmacotherapy and operative measures for the reconstruction of fingertip injuries, with a local flap using the V-Y flap method.
CHARACTER BUILDING AS ONE OF THE FOCUSES OF NATIONAL DEVELOPMENT PLANNING IN INDONESIAN LEGISLATION
Authors: Susmayanti Riana
Published: August 2023

Character building is the foundation for realizing the vision of national development, which is to create a noble, moral, ethical, cultured, and civilized society based on the philosophy of Pancasila. Based on this background, the legal issues in this research are: 1) What is the object of character building that become the focus of national development planning? and 2) How is character building regulated in legislation? This research uses a statutory approach and a conceptual approach. The objects of character building that becomes the focus of national development planning are the character building of children, youth and the State Civil Apparatus. Character building regulated in several regulations, namely: Law No. 5 of 2014 on State Civil Apparatus, Amendment to Child Protection Law, Amendment to the Marriage Law, Law No. 18 of 2019 on the Islamic Boarding Schools, Law No. 11 of 2022 concerning Sport, Law No. 12 of 2022 on the Sexual Violence Crimes and Law No. 23 of 2022 on the Psychology Education and Services.
CHARACTER BUILDING IN THE PERSPECTIVE OF PANCASILA: A CASE STUDY OF ISLAMIC RELIGIOUS EDUCATION STUDENTS
Authors: Ladamay Ode , Mustakim Mustakim
Published: August 2023

The values of character building in students are a reflection of the institution in preparing future generations who have religious, tolerant, democratic and love the country’s characters. The purpose of this study is to describe character building for students, and the implementation of character building in the perspective of Pancasila. This research uses a qualitative method with a case study type of research. The results of the study illustrate that: (1) character building in students is seen in student discipline when attending lectures offline and online. In addition, student creativity when attending lectures is getting better with creative ideas, high curiosity leads students to have an attitude to ask questions and provide arguments in accordance with the experiences students have. character building for students is also seen in the responsibilities of students in submitting assignments for Pancasila Education courses in a timely manner; and (2) the implementation of character building in accordance with the perspective of Pancasila is manifested in the core values of Pancasila which are internalized in the first precept character building reflected in the behaviour of diligent worship, and tolerance between religious communities; the second precept is reflected in polite behaviour, mutual respect, and as an example; the third precept which is manifested through a sense of unity and oneness, a spirit of self-sacrifice, and love for the motherland; the fourth precept through the embodiment of always respecting the opinions of others, prioritizing deliberation for consensus, and upholding democracy; and the fifth precept through fairness in opinion, mutual welfare, and always respecting each other's self-actualization.
Аморфный лед средней плотности, полученный разложением водно-гелиевого геля
Authors: Синицын В.В. , Рыбченко О.Г. , Ефимов В.Б. , Вирюс А.А.
Published: August 2023

The article presents experimental studies of structural changes that occur during heating of nanosized powders of amorphous ice obtained by decay of a water-helium gel. Thermal annealing of the obtained samples was carried out by short exposures (about 15 minutes) at different temperatures in the range of 110-230K. The behavior of the amorphous phase during annealing was analyzed within the framework of its description by a mixture of amorphous ices of low and medium density (LDA and MDA, respectively). It was found that at the such description, the virgin sample was predominantly in the MDA state, while the proportion of the LDA phase was about 7 times less (MDA/LDA ≈ 7:1). It has been established that during annealing, a multistage process of structural transformations of the initial LDA + MDA sample takes place: from initial changes in the amorphous state at 110 K through crystallization of the cubic ice phase Ic with its intensive growth at a temperature of 130 K to the transformation of cubic ice into the hexagonal phase Ih in the temperature range T =135÷230K.
Исследование магнитоэлектрического эффекта и термоэдс в композитном железозамещенном пиростаннате висмута Bi-=SUB=-2-=/SUB=-(Sn0-=SUB=-0.7-=/SUB=-Fe-=SUB=-0.3-=/SUB=-)-=SUB=-2-=/SUB=-O-=SUB=-7-=/SUB=-/Bi-=SUB=-2-=/SUB=-Fe-=SUB=-4-=/SUB=-O-=SUB=-9-=/SUB=-
Authors: Удод Л.В. , Аплеснин С.С. , Ситников М.Н. , Романова О.Б.
Published: August 2023

The composite compound Bi2(Sn0.7Fe0.3)2O7/Bi2Fe4O9 in the ratio 91/9% was synthesized by the solid-phase reaction method. The current-voltage characteristics were studied in the temperature range 800-400 K. The hysteresis of the current-voltage characteristics was found. The magnetoelectric interaction and thermoelectric power have been studied. The temperatures of predominance of the even and linear functions of the magnetoelectric effect are established. The sign change of the thermopower has been found.
Микроструктура сферолитовых тонких пленок цирконата-титаната свинца
Authors: Старицын М.В. , Пронин В.П. , Хинич И.И. , Сенкевич С.В. , Каптелов Е.Ю. , Пронин И.П. , Елшин А.С. , Мишина Е.Д.
Published: August 2023

The features of the microstructure of radiant spherulites in lead zirconate titanate thin films are studied using scanning electron and nonlinear optical microscopy by varying the blocks size of the perovskite structure. It is shown that with an increase in the radius of the spherulite (or the size of blocks), the angle of rotation of the growth axis increases, the speed of the angle of rotation, and the magnitude of the signal of the second optical harmonic It is assumed that the reasons determining specifics of the structure and signal of the second optical harmonic are associated with a change in the magnitude of mechanical stresses in the films that arise due to a change in the phase density at perovskite phase crystallization from low-temperature pyrochlore phase or at perovskite phase recrystallization
Эволюция спектральных и структурных характеристик боратов, образующихся при взаимодействии оксидов лантана и индия с расплавом тетрабората калия
Authors: Шмурак С.З. , Кедров В.В. , Киселев А.П. , Фурсова Т.Н. , Зверькова И.И.
Published: August 2023

The structure, morphology, IR spectra, as well as luminescence spectra and luminescence excitation spectra of europium-doped borates formed during the interaction of lanthanum and indium oxides with a potassium tetraborate melt at 970 °С have been studied. With an increase in the In3+ concentration in the batch, a sequential change of the following structural states is observed: single-phase LaBO3 aragonite, LaBO3 aragonite + InBO3 calcite, single-phase InBO3 calcite. The correspondence between the structure and spectral characteristics of these compounds has been established. It is shown that indium and lanthanum orthoborates do not form joint solid solutions.
Исследования магнитных наночастиц Mn-=SUB=-x-=/SUB=-Fe-=SUB=-3-x-=/SUB=-O-=SUB=-4-=/SUB=-@OA (0≤ x≤ 1.0) функционализированных олеиновой кислотой (ОА) для биомедицинских применений
Authors: Камзин А.С. , Dogan N. , Dogan O.M. , Семенов В.Г.
Published: August 2023

Functionalization (or coverage) MNF is a unique tool for creating particles with the properties required for biomedical applications. Therefore, the study of the magnetic properties of coated MNCs is the most important task of our time. The effect of changes in the concentration of Mn ions on the properties of MnxFe3-xO4 nanoparticles coated with oleic acid (OA) MnxFe3-xO4@OA (where x = 0, 0.25, 0.5, 0.75 and 1.0) to create stabilized magnetic fluids for various applications is investigated. The synthesis of MnxFe3-xO4@OA MNPs was carried out by thermal decomposition using manganese-oleate and iron oleate. The properties and phase states of the obtained MNPs were studied by X-ray diffraction (XRD) and Mossbauer spectroscopy. To understand the behavior of MNCs in small magnetic fields during hyperthermic treatment, Mossbauer studies of MnxFe3-xO4@OA particles were carried out when a magnetic field with a strength of 1.7 kOe was applied. It is established that the thermal decomposition method makes it possible to obtain single-phase superparamagnetic particles promising for biomedical applications
Влияние термической обработки на структуру и электрохимические характеристики композита на основе многостенных углеродных нанотрубок и оксида марганца
Authors: Несов С.Н. , Стенькин Ю.А. , Корусенко П.М. , Болотов B.B. , Матюшенко С.А.
Published: August 2023

In this paper, the effect of heat treatment in an inert medium on the structure and electrochemical characteristics of a composite based on multi-walled carbon nanotubes (MWCNTs) and manganese oxide formed by deposition from a KMnO4 solution is investigated. As a result of heat treatment composite (500°C) in argon on the surface of multi-walled carbon nanotubes are formed nanoparticles of non-stoichiometric manganese oxide. X-ray photoelectron spectroscopy data indicate a high degree of functionalization of the surface of carbon nanotubes by oxygen-containing groups, as well as the possible formation chemical bonds at the interfaces of the composite. Electrochemical measurements showed that the specific capacity of the composite after heat treatment (88-50 F/g) exceeds the capacity of the original MWCNTs (18-15 F/g) in the current range discharge 0.1-1A/g.
States of silicon nanoclusters containing carbon impurities
Authors: Tashmetov M. Yu.  , Makhkamov Sh. M.  , Umarova F. T.  , Normurodov A. B.  , Sulaimanov N. T.  , Khugaev A. V.  , Kholmedov Kh. M.
Published: August 2023

The structural and electronic states of defective complexes in the Si29 cluster with the participation of carbon and hydrogen atoms were determined by the method of non-conventional strong binding (MNSB) in combination with the method of molecular dynamics. It is shown that carbon atoms in silicon clusters form a bridge bond with two silicon atoms and localized in a hexagonal position at the center of the cell, forming a defect of the Si29 : Ci type. The introduction of hydrogen into a silicon cluster results in the formation of a defective Ci-H-Si complex and a decrease of binding energy of the Si29 : Ci defect. Based on the calculations, it was found that presence of leads to carbon gives shallow levels in the band gap of nano-silicon, and the defective carbon-hydrogen complex in a hydrogenated cluster, depending on the charge state of the defective complex. Moreover this exhibits both deep and shallow levels. Keywords: MD and MNSB methods, silicon nano-clusters, hydrogenated cluster, structural defects, ab initio methods, carbon and hydrogen atoms, spatial structure, shallow and deep levels.
Electronic Screening Of Perinatal Depression In Kampala, Uganda – Survey Results (Preprint)
Authors: Namatovu Hasifah Kasujja , Magumba Mark Abraham , Akena Dickens
Published: August 2023

BACKGROUND

New and expectant mothers face several unique health challenges related to the physical and psychological changes accompanying motherhood. However, in low-income settings where mothers grapple with meeting basic physical needs like access to safe water, proper nutrition, access to health facilities and health workers, psychological needs may end up being ignored. Psychological needs are an important factor that can impact the physical health of the mother and the development of the child.

OBJECTIVE

In this paper, we report key findings from a survey of perinatal depression in 7518 women in Kampala, Uganda. The goal of the exercise was to establish statistical baselines for the prevalence of perinatal depression in Kampala and understand its relationship with key demographic variables.

METHODS

We employed an Android implementation of the Edinburgh Postnatal Depression Scale (EPDS). The scale gives depression scores from 0 to 30. Results were transmitted to a web-based backend MySQL server. Two EPDS depression classification scales were employed. The more common coarse-grained binary classification flags respondents who score 13 on the EPDS and above as possibly depressed.

RESULTS

Based on this classification it was found that 21.83% (95% CI: 20.91%–22.79%) of respondents were possibly depressed. We also employed a more detailed fine-grained classification, which classifies scores of 6 or less as minimal or mild depression, scores of 13 or less as mild depression, scores of 19 or less as moderate depression and scores greater than 20 as severe depression. Based on this classification, 60.59% (95% CI: 59.47%–61.69%) of respondents were found to be mildly depressed. 19.59% (95% CI: 18.7%–20.51%) of respondents were flagged as moderately depressed and 17.58% (95% CI: 16.73%–18.46%) were flagged as not or minimally depressed and 2.23% (95% CI: 1.91%–2.59%) were found to be severely depressed.

CONCLUSIONS

Spousal employment category was found to be a key determinant for respondents’ overall depression and anxiety score and respondent’s relationship status was found to be an important factor for suicidal ideation. This conclusively means that financial stability greatly influences mental stability and as such, advocacy to have men support their spouses is crucial