bluuebunny/crossref_metadata_2025 huggingface dataset:
Rancang Bangun Digital Signage Sebagai Papan Informasi Digital Masjid Di Kota Palangka Raya Berbasis Web Responsive
Authors: Ichsan Mochammad , Sam'ani Sam'ani , Haris Ferdiyani , Qamaruzzaman M. Haris
Published: February 2022

Until now, mosques are still often found in providing information such as prayer schedules, study schedules, financial reports, appeals still use wooden boards or triplex so that it can only be known by people who enter or worship at the mosque and the information is still very monotonous. There are still a few mosques that already have information screens in the form of television screens that present prayer times, running texts about study info, but they are still limited and have not been equipped with study pamphlets and mosque cash reports. Most mosques in the city of Palangka Raya and its surroundings still do not have information screens because the cost of the equipment is relatively too expensive, so they only use bulletin boards and paper pasted on the mosque walls to display or inform prayer schedules, routine studies and Friday sermons and other important information. So it is necessary to have a tool application in the form of information screens throughout the mosques in Palangka Raya and its surroundings that can display prayer schedules, regular studies and Friday sermons and other important information in an integrated manner so that people can see the desired mosque information through smartphone media, Besides that, mosque administrators or ta'mir can manage their own content or information media content according to the needs of the mosque by utilizing digital signage so that the form of delivering information through electronic display media is carried out dynamically and attractively. The method used in this research is to use the System Development Life Cycle (SDLC). Software development uses the Waterfall software development model.
Perbandingan Hasil Pemeriksaan Hitung Jumlah Eritrosit Menggunakan EDTA Konvensional dan Vacutainer
Authors: Dewi Lilis Septiana , Sudarsono Tantri Analisawati , Sulistiyowati Retno
Published: February 2022

Hematology examination in practice often uses anticoagulants to prevent clotting in blood samples, including in the examination of the erythrocyte count. The anticoagulant that is often used for examination is EDTA (Ethylene Diamine Tetra Acetic Acid). With the changing times, the addition of anticoagulants to the examination is no longer done conventionally but is already contained in the vacutainer tube. However, the vacutainer anticoagulant cannot be adjusted to the blood volume obtained during phlebotomy, while the conventional anticoagulant can be added according to the blood volume obtained. This research is a pre-experimental research design with a One-Shot Case Study design, in which each blood sample is added with conventional anticoagulants and vacutainers. The method used is manual using a hemocytometer and a microscope. Analysis of the data using the Independent T-test. The purpose of this study was to find out the comparison of the results of the erythrocyte count using conventional EDTA and a vacutainer. After examination with both anticoagulants, p-value = 0.822 (p>0.05) so there is no comparison. Based on these results, it can be concluded that there is no comparison of erythrocyte count examination using conventional EDTA and vacutainer.
Analisis Pengaruh Tingkat Pendidikan Ibu dan Pemberian ASI Eksklusif terhadap Kejadian Stunting pada Balita di Provinsi Kalimantan Tengah
Authors: Handayani Rezqi , Qamariah Nurul , Munandar Haris
Published: February 2022

Based on data from the 2019 Indonesian Toddler Nutritional Status Study (SSGBI) the lowest prevalence of stunting was Murung Raya (17.45%), Lamandau (17.83%), and West Kotawaringin (23.98%). Meanwhile, the districts with the highest prevalence were Kapuas (42.37%), East Kotawaringin (39.87%), and East Barito (38.53%). The results of routine monitoring of nutritional status carried out by districts/cities through E-PPBGM stated that the percentage of undernourished children aged 0-59 months in Central Kalimantan Province in 2019 was 10.1 %. One of the bad effects of nutritional problems is stunting. The case of stunting in children under five is still a health problem that needs to be watched out for in Indonesia. One of the factors causing stunting is the mother's education level and the provision of breast milk (ASI) to infants and toddlers. The study analyzed the relationship between maternal education level and exclusive breastfeeding for children under five with stunting in Central Kalimantan Province. This study used a cross-sectional research design with univariate data analysis and bivariate analysis. The Univariate analysis aims to describe the distribution of children under five by age, by gender, level of mother's education, distribution of exclusive breastfeeding, and nutritional status of children under five based on health profile data in the form of a frequency distribution table. Bivariate analysis in this study used the Chi-square test. The results showed that there was a significant or significant relationship between the level of mother's education and exclusive breastfeeding with the incidence of stunting in children under five in the province of Central Kalimantan in 2019.
Uji Aktivitas Analgetik Ekstrak Batang Karamunting (Rhodomyrtus tomentosa) terhadap Tikus Jantan Galur Wistar
Authors: Safitri Rika Arfiana , Rahayu Mamik Ponco , Widodo Gunawan Pamudji
Published: February 2022

Pain is only a symptom and a mechanism in the body that serves as a danger signal about a disturbance in the tissue such as inflammation, infection, or muscle spasms. This study aims to determine the effect of the analgesic effect of the ethanol extract of the karamunting stem. Karamunting stems were extracted by the maceration method using 96% ethanol as solvent. Each analgesic test was divided into five groups, namely a negative control group (CMC Na), a positive control group (Tramadol), a karamunting stem extract test group (a dose of 100 mg/kg BW, 200 mg/Kg BW, and 400 mg/Kg BB). Analgesic test using Tail flick method. Data analysis used the Shapiro-Wilk test and then continued with the one-way ANOVA test. The results showed that the ethanol extract of the karamunting stem could provide an analgesic effect at a dose of 200 mg/Kg BW.
Program Pemberdayaan dan Pengembangan Kewirausahaan Pondok Pesantren Mahasiswa Ma’arif NU Kota Metro Melalui Karya Seni Kaligrafi
Authors: Amrulloh Hanif , Hidayatullah Rizky , Setiawan Agus , Zarnuji Ahmad , Setiawan Dedi , Jaenullah Jaenullah
Published: February 2022

Islamic boarding schools for students are Islamic educational institutions with a boarding system in which students from Islamic boarding schools have Islamic religious education and general knowledge from universities. The Islamic Student Boarding School of the Ma'arif NU Islamic Institute in Metro City is located in Metro, Lampung. So far, there are approximately 70 students at the Ma'arif NU student boarding school in Metro City. There are prospects for advancement in entrepreneurial skills centered on this opportunity. To improve students in general education and Islamic scholarship, but with other skills currently needed, one of which is entrepreneurship. Making calligraphy art with tremendous economic potential is one of the skills taught in Islamic boarding schools. The goals of this program include introducing entrepreneurship to student students, learning how to use Prada techniques to create calligraphy art, and applying calligraphy art-making as an entrepreneur. The ABCD method was used for the assistance given to Metro City Ma'arif NU Islamic boarding school students. In this strategy, service prioritizes using capacity and assets that the group already has. In this approach, the capacity or potential is the direct assistance of society in achieving progress. The assistance results showed that the students managed to develop a calligraphy company that was run at an entire profit to fund the needs of the Islamic boarding school students. Students are not solely dependent on parental submissions based on these benefits. The outcomes of the calligraphy efforts carried out will fulfill the needs of entrepreneurial learners.
Penyuluhan Warehouse Management pada UMKM melalui Perbaikan secara Berkelanjutan
Authors: Rini Monanda Wandita , Ananda Nessa
Published: February 2022

The business development that is getting faster needs continuous improvements. Implementation of continuous improvement is carried out in large companies and needs to be carried out by MSMEs (Medium Small Micro Enterprises). One activity that needs to be appropriately managed by MSMEs is warehousing. Optimal warehouse management can improve MSME business performance. However, MSMEs do not own knowledge and awareness of continuous improvement optimally. This resulted in warehouse management has not performed optimally by MSMEs. This community service activity aims to provide knowledge to MSMEs about how to identify Muda, Mura, Muri and how to make continuous improvements in warehouse management. Implementing activities is carried out by direct observation and counseling to MSMEs. This community service activity was carried out for two days. The counseling activity was carried out on April 27, attended by owners and employees of Puppet MSMEs in Bogor. The counseling was carried out by providing material on the concept of continuous improvement and identification of Muda, Mura, Muri and continued with a discussion session.
Pemberdayaan Masyarakat Desa Bendolo melalui Diversifikasi Olahan Talas (Colocasia esculenta)
Authors: Prayitno Sutrisno Adi , Pribadi Heri Purnama , Sugiarto Dinta , Alfatina Ainanda
Published: February 2022

Bendolo Village is one of the villages located in Sawahan District, Nganjuk Regency. Many of the people of Bendolo Village cultivate taro plants, but the yields are not used optimally. The crops are only sold raw at low prices due to limitations in processing or utilization. Ignorance of taro processing technology makes taro plants just planted and not a priority in processing. The crops are only sold fresh. People rarely process it in the form of food or snacks. Hence, community service activities (PKM) aim to increase the knowledge and income of the family welfare empowerment group (PKK) by utilizing the diversification of processed taro into taro noodles and taro chips. Implementing the community service uses lectures, discussions, and direct demonstrations related to taro processed products. The activities began with a demonstration of raw material handling, how to use the noodle grinder and mixing materials to packaging and storage. The result of the training is that almost 100% of the family welfare empowerment group (partners) can make taro processed and pack it well.
MATEMATIKA DALAM AKSIOLOGI
Authors: Marliani Marliani
Published: February 2022

Penelitian ini dilatarbelakangi oleh adanya beberapa orang yang kurang mengabdi pada matematika, hal ini dapat diamati oleh setiap guru matematika bahwa dalam suatu kelas siswa yang diperkirakan berjumlah sekitar tiga puluh orang, yang paling dominan dan yang paling dominan adalah siswanya. siswa yang serius seperti matematika berkisar dari sekitar tujuh siswa. Selanjutnya jika matematika dikaitkan dengan kajian aksiologi (implementasi) dalam filsafat ilmu, maka manfaat mempelajari matematika dalam kehidupan sehari-hari sangat bermanfaat bagi siswa, terutama dalam praktik jual beli di warung, di pasar dan berbagai kegiatan ekonomi lainnya. kegiatan di masyarakat. Tujuan dari penelitian ini adalah untuk mengetahui konsep aksiologi dalam filsafat ilmu dan konteksnya dalam mempelajari matematika serta untuk mengetahui titik keterkaitan manfaat matematika dengan kehidupan sehari-hari di masyarakat. Penelitian ini menggunakan metode penelitian kepustakaan dan juga eksperimen. Yaitu metode kepustakaan yang dilakukan untuk mengumpulkan data-data yang berkaitan dengan penelitian sebelumnya, sedangkan dilakukan dengan mengambil sampel praktik pembelajaran di sekolah dimana peneliti menjadi guru matematika di MTsN 2 Palangka Raya.

Hasil penelitian ini adalah konsep aksiologi dalam filsafat ilmu yaitu implementasi dari ilmu yang telah dipelajari dari pelajaran matematika ternyata memiliki nilai manfaat yang sangat besar bagi setiap orang, adapun kegunaan matematika bagi kehidupan sehari-hari, ternyata matematika memiliki banyak manfaat. dan nilai positif dalam menunjang kehidupan manusia di bidang ekonomi.
A Square to Park
Authors: Akbulut Fatma Sinem , Aycı Hilal
Published: February 2022

In this study, the dynamics of the formation and transformation of Zafer Square, an essential urban space of Ankara, are examined in an attempt to draw attention to the square-park dilemma observed in its description as an urban open space. Accordingly, the historical process is chronologically divided into three periods while examining the causes of this dilemma. Initially, a theoretical discussion based on literature research is conducted to ascertain whether this area is a square or a park in the context of public spaces. In the first period, the Early Republican Period (1923–1945), the formation of Zafer Square was examined, while in the second period, which denotes the Democratic Party Period (1950–1960s), the change in its meaning and spatiality is questioned. The interventions on Zafer Square and Atatürk Boulevard are discussed as indicators of this political evolution and its reflection on urban space and Yenişehir. In the last section, the issues caused by its transformation to Zafer II Park on one side and an undefined space on the other side are scrutinised as it lost its meaning and characteristics as a boulevard square with the new structuring on the east side.
Ansiedad dental y pensamientos automáticos en pacientes odontológicos de la Cruz Roja, provincia de Tungurahua
Authors: Lara-Machado Juana Rosario , Lara-Barros Betsabe Patricia
Published: February 2022

INTRODUCCIÓN. Se observó deficiencia de información en cuanto a la relación entre los pensamientos automáticos y el miedo al dentista, el cual es la razón principal para evitar o posponer el tratamiento odontológico comprometiendo la salud oral. OBJETIVO. Examinar la correlación entre los niveles de ansiedad dental y los pensamientos automáticos en los pacientes odontológicos de la Cruz Roja en la provincia de Tungurahua. MÉTODO. Estudio no experimental de tipo transversal con alcance explicativo, correlacional. Se emplearon tres escalas: Kleinknecht Dental Fear Scale (DFS), la Encuesta de Ansiedad Dental Modificada de Corah (MDAS) y el Inventario Automático de Pensamientos de Ruíz y Luján mientras que el análisis estadístico se realizó mediante alfa de Cronbach. RESULTADOS. El análisis demostró que los pensamientos automáticos más comunes son: filtraje (51%), falacia de razón (54%), falacia de recompensa divina (54%) y "debería" (50%). Así también, el 65.9% presentó niveles moderados de miedos dentales y el 46.2% niveles de ansiedad dental leve.  DISCUSIÓN Y CONCLUSIONES. Los resultados revelaron que los niveles de ansiedad dental varían en términos del procedimiento dental que han experimentado los pacientes y el bajo nivel de ansiedad se relaciona con el elemento relacional del profesional.
Мовно-літературна освіта: дослідження, методи, практика
Authors:   Східноукраїнський національний університет імені Володимира Даля, Бондаренко Галина , Галенко Анна ,   Східноукраїнський національний університет імені Володимира Даля, Карловас Олена ,   Східноукраїнський національний університет імені Володимира Даля, Кравченко Олена ,   Східноукраїнський національний університет імені Володимира Даля, Пустовіт Валерія ,   Східноукраїнський національний університет імені Володимира Даля, Токар Наталія ,   Східноукраїнський національний університет імені Володимира Даля
Published: February 2022

У монографії розглянуто питання ‎розвою української літератури в пе-ршій ‎половині ХІХ ст. (на основі епістолярних ‎джерел); особливості ідіостилю ‎В. Рутківського; описано концепти ‎культури у творах світо-вої літератури; ‎репрезентовано традиційні та інноваційні ‎аспекти су-часного уроку української ‎мови, що пов’язані з формуван-ням ‎комунікативної активності здобувачів ‎освіти; визначено методичні перспективи ‎наукових досліджень української ‎літератури у формуванні національної ‎свідомості школярів.‎ Призначено для філологів, лінгвістів, ‎здобувачів освіти та широкого кола ‎читачів, які цікавляться мовно-‎літературними питаннями.‎
Removal of nutrients by corn depending on fertilization and liming in Western Polissia
Authors: Polovyi V. , Yashchenko L. , Rovna H.
Published: February 2022

The article presents the results of liming and fertilization inﬂuence on the content and removal of nitrogen, phosphorus and potassium by maize on sod-podzolic sandy soil of Western Polissia. It was determined that the content of the main nutrients varied within 1.63–1.90 and 0.77–0.86 % for nitrogen, 0.51–0.59 and 0.32–0.41 % for phosphorus, 0.31–0.45 and 1.24–1.32 % for potassium respectively in the main and by-products. The highest accumulation NPK data were noted in the variant with application a 1.0 dose by hydrolytic acidity (Ha) of dolomite ﬂour and N120P90K120 with addition of S40 and micronutrient fertilizer Nutrivant Plus Cereals (2 kg/ha). The total uptake of elements mainly depended on the combination of fertilizer components and liming doses. The maximum removal data were established for variants with a 1.0 dose by Ha of dolomite ﬂour, norms of mineral fertilizers N120P90K120 and the addition of S40, as well as S40 and micronutrients fertilizer Nutrivant Plus Cereals (2 kg/ha). These data 1.8–2.3 times for the main product and 2.0–2.3 times for by-products exceeded the control. A more stable indicator that will make it possible to adjust the crop nutrition system is the removal of nutrients per unit of the main and the corresponding amount of by-products. It was found that with liming and fertilization, the consumption of nitrogen, phosphorus and potassium by corn plants and the normative removal rate increase. In the experiment, high values of removal of 33.5 and 32.6 kg/t of nitrogen, 12.3 and 12.4 kg/t of phosphorus, 26.9 and 24.1 kg/t of potassium were obtained with the integrated application a 1.0 Ha dose by Ha of dolomite ﬂour, N120P90K120 with the addition of sulfur, as well as sulfur and trace elements.
Key words: corn, liming, fertilizers, productivity, nitrogen, phosphorus, potassium, elements content, nutrients removal.
The General Solution of Minisuperspace Wheeler-De Witt Equation
Authors: Chowdhury Anjan Kumar , Aktar Shomi
Published: February 2022

Wheeler-De Witt (WDW) equation is the central equation of canonical quantum gravity. For its infinite dimensionality to get a meaningful solution of that equation is very hard. To extract minimal information, one has to consider WDW equation in Minisuperspace where there are only two variables, such as known radius of the Universe and the scalar field. In this paper we find the general solution of WDW equation in Minisuperspace. We discuss the physical significance of our solution.
The Chittagong Univ. J. Sci. 43(1): 67-74, 2021
Ultrastructural changes of the gingival mucous membrane of patients with chronic generalized periodontitis and coronary artery disease
Authors:   Lviv National Medical University named after Danyla Halytskoho, Lviv, Ukraine, Skybchyk O. , Kovalyshyn V. ,   Lviv National Medical University named after Danyla Halytskoho, Lviv, Ukraine, Solomenchuk T. ,   Lviv National Medical University named after Danyla Halytskoho, Lviv, Ukraine, Martovlos (Hodovana) O. ,   Lviv National Medical University named after Danyla Halytskoho, Lviv, Ukraine
Published: February 2022

Abstract. Coronary artery disease (CAD), which is based on atherosclerotic lesions of vessels and systemic hemodynamic disorders, can cause profound metabolic and functional disorders in periodontal tissues, including the hemomicrocirculatory bed. The purpose. With the use of electron microscopy method of study to complement the scientific data on the structure of the gingival mucous membrane , in particular the epithelial layer, cells and cellular elements, stromal structures and hemocapillaries of the connective tissue of the gums in patients with CGP and CAD. Materials and methods. Electron microscopy study was performed in 10 patients (mean age 54.2±5.3 years) with CGP initial-I, II degree and CAD. The material for the study were gingival biopsy samples fixed in the 2 % solution of osmium tetroxide in 0.1 M phosphate buffer. Ultrathin slices were obtained with the ultramicrotome УМТП-3М and studied using the electronic microscope УЭМВ-100К. Results. Study of the ultrathin slices of the gingival mucous membrane in patients with CGP and CAD revealed changes which are typical for tissue hypoxia. Disorders of local blood circulation are primarily associated with narrowing of the hemocapillaries or their dilation. It was observed the violation of the blood rheological properties in these microvessels, which were manifested by the erythrocyte hyperaggregation in the lumens of hemocapillaries and plasma hypercoagulation. It was revealed the changes in the epithelial layer of the connective tissue of the gums, in particular, an increase in the area of penetration of the basement membrane into the main substance of connective tissue, changes in the shape and intracellular structures of cells of the spinous and granular layers, disintegration of intercellular desmosomes. The presence of disorganized unmyelinated nerve fibers indicates the local dysfunction of the autonomic nerve fibers of the gingival mucous membrane. Conclusions. Electron microscopy study revealed ultrastructural changes in the gingival mucous membrane in patients with CGP and CAD, which are the result of hypoxia in periodontal tissues. Key words: ultrastructure, gingiva, hemocapillaries, hypoxia, generalized periodontitis, coronary artery disease.
Features of determination of masticatory efficiency at patients with postoperative defects of an oral cavity
Authors:   Vinnytsia National Medical University named after E. Pyrogova, Vinnytsia, Ukraine, Kushta A.
Published: February 2022

Resume. The aim of the study was to improve the determination of masticatory efficiency in patients with oncopathology of the oral cavity before and after surgery. For this purpose, the analysis of masticatory efficiency in dynamics was performed using a two-color chewing gum in 29 patients with tumors of the tongue, oral mucosa and lower jaw. After surgery, masticatory parameters decreased compared to the weekend and did not recover for 7 days after surgery. In patients diagnosed with stage I-III mandibular cancer, masticatory values are below 0.5 (0.34±0.04; 0.28±0.03; 0.24±0.03), indicating poor bolus formation. This method is informative for the formation of the bolus, taking into account not only the presence of teeth, but also the function of the muscles involved in chewing. Key words: masticatory efficiency, defects of the oral cavity, tumors of the tongue, the bottom of the oral cavity, the jaw.
Der Kienlung-Hruek des mongolischen Geschichtswerkes Erdeniyin tobci von Sagang Sexen.
Authors: Jokinen Raija
Published: February 2022

.
Müveltség és hagyomány. Studia Ethnologica Hungariae et Centralis ac Orientalis Europae. I–II
Authors: Schellbach Ingrid
Published: February 2022

.
Magyar Népköltézet I–III, hrsg. von Gyula Ortutay; Magyar Népmesék I–III, hrsg. von Gyula Ortutay; Imre Csanádi & Lajos Vargyas Röpülj páva röpülj; A magyar Népszene Tára I–IV, hrsg. von Béla Bartók & Zoltán Kodály; Péter Morvay & Ernö Pesovár Somogyi tá
Authors: Schellbach Ingrid
Published: February 2022

.
S. I. Irikov Azbuka dlja 1–go klassa sel'kupskih shkol; Eugene Helimski The language of the first Selkup books; Hartmut Katz Selcupica III; János Pusztay Die Pur-Mundart des Waldjurakischen; Michael Katzschmann Nominal- und Esse-Satz in den samojedischen
Authors: Janhunen Juha
Published: February 2022

.
Ingrid Schellbach-Kopra Finnisch-deutsches Sprichwörterbuch
Authors: Hakamies Pekka
Published: February 2022

.
A. v. Gabain Das Leben im uigurischen Königreich von Qoco [850–1250]. I. Textband.
Authors: Joki Aulis J.
Published: February 2022

.
Congressus secundus internationalis fenno-ugristarum. Pars II
Authors: Lehtonen Juhani U. E.
Published: February 2022

.
Partitiv und Inkongruenz beim Subjekt des Finnischen
Authors: Schlachter Wolfgang
Published: February 2022

.
Über die Ortsnamen Nordrusslands auf -as
Authors: Tunkelo E. A.
Published: February 2022

.
Die Verwendung des nominativischen und illativischen Infinitivs im Mordwinischen
Authors: Saukkonen Pauli
Published: February 2022

.
Die Lapplandreise des Seigneur A. de La Motraye i. J. 1718
Authors: Stipa Johannes G.
Published: February 2022

.
Lexikalisierung von grammatischen Mitteln in der heutigen ungarischen Sprache
Authors: Tompa J.
Published: February 2022

.
Zur Erforschung moderner ethnokultureller Prozesse bei den Saamen der Halbinsel Kola
Authors: Grigor'eva Regina , Lukjanchenko Tatjana
Published: February 2022

.
Géza Bárczi 1894–1975
Authors: Nyirkos István
Published: February 2022

.
Pandemia, pedagogías y complejidad
Authors: Tovar-Granados Oscar
Published: February 2022

Este ensayo mostrará que la pandemia del coronavirus no es un problema aislado, sino la manifestación de una crisis mayor o policrisis del sistema civilizatorio de la modernidad occidental; por tanto, de lo que se trata es de explorar y trazar nuevas rutas, entre ellas, las epistémicas, atendiendo a la concepción de hombre, a las lecciones del contexto pandémico, los desafíos por afrontar y a las necesidades a que cambiemos de vía.
Orthognathic Surgery Impression on Quality of life: Integral Perception
Authors: Al-Rawee Rawaa Y. , Mohammed Sharif Ahmad G. , Tawfeeq Bashar Abdul-Ghani
Published: February 2022

Background: Patients with severe functional abnormalities are disappointed with their real facial appearance. Assessing the different perceptions and motivations influence in patients seeking orthognathic surgeries on their quality of life are the aims of this clinical study. This done by applying specific questioners' forms before and after treatment for demonstrates the patient's satisfaction with the result too. This can improve the success rate of orthognathic surgeries by improve patients expectations and satisfactions. Material and Method: Fifty participants are chosen to share in this retrospective study attained the Multi- Disciplinary Team Committee in Al-Salam Teaching Hospital. Patients' age groups are from 17-40 years, no specific gender included in the study. Patients agree to participate and answering the uestioners pre and post surgeries. Patients are nonsmokers with no medical disease history. Out of these inclusion criteria; patients excluded from the study. Patients with cleft lip and palate or any other syndromes that affect the dentofacial growth are also excluded. Result: Age, gender, education level and marital status as social variables intended in this study; show no statistical differences concerning the questioner's answers as reached by statistical analysis by Independent Sample t Test and One Way Anova Test. Significant differences (0.000) have been observed between preoperative and postoperative satisfaction according to Paired Sample t Test. Conclusion: Reaching optimum patients satisfaction is challenge as well as changing quality of life of our patients are provocation. In this article by using of different multiple questioners for integral perception in orthognathic surgery patients are crucial and more suitable for good understanding of patient's willing.
Effect of Khat Consumption on Oral Health: Study Carried Out in Djibouti City
Authors: Bennani Anas , Mohamed Sagal Ibrahim
Published: February 2022

Introduction: The purpose of the present investigation is to determine the oral effects of regular khat consumption in Djibouti by placing risk factors and symptoms related to consumption as a contribution to the ongoing scientific discourse. Materials and Methods: A cross-sectional epidemiological survey was carried out on 129 patients consulting in a health center affiliated to the CNSS, located in the capital of the Republic of Djibouti, Djibouti-City from August to October 2017. The support of the survey is a questionnaire including an interview and a clinical examination. The subjects are divided into regular khat consumers (CK) and non-khat consumers (NCK). Results: Our sample is divided into 48.1% CK and 51.9% NCK. 80.7% of CK and 38.8% of NCK are male. 58.1% of CK and 88.1% of NCKs report a frequency greater than or equal to 2 brushings / day. 62.9% of CK and 4.5% of NCK are tobacco users (CT). 77.4% of CK and 20.9% of NCK are consumers of sweetened beverages. 62.9% of CK and 16.4% of NCKs report symptoms of dry mouth. 38.7% of CK and 16.4% of NCK suffer from TMJ pain. 32.3% of CK and 14.9% of NCK complain of changes in taste perception. 29% of CK and 4.5% of NCK have burning sensations in the tongue or other parts of the oral cavity. 24.2% of CK and 7.5% of NCK report loss of prosthetic restorations and / or strides. The plate indices of CK and NCK are 1.6 (+/- 0.13) and 1.4 (+/- 0.13), respectively. The gingival indices of CK and NCK are respectively 1.64 (+/- 0.13) and 1.57 (+/- 0.09). 24.2% of CK and 1.5% of NCK have whitish lesions of leucoplastic appearance. 79% of CKs and 23.9% of NCKs have recessions. 22.6% of CKs and 6% of NCKs suffer from spoiled restorations. 24.2% of CK and 9% of NCK suffer loss of fixed prosthetic restorations. Discussion: Similar to studies in Yemen and Israel, there is a slight predominance of NCKs in our sample. The consumption of khat is also significantly associated with the male sex. A number of articular, mucosal and dental symptoms are significantly associated with khat consumption. Ethiopian, Yemeni and Israeli studies are in agreement with our results. In agreement with a Yemeni study but in contradiction with a Kenyan study, there is a significant association between khat consumption, poor oral hygiene and increased plaque index. Nevertheless, an association between khat consumption and gingival inflammation is not established. In agreement with Israeli and Yemeni studies, there is a significant association between khat consumption, whitish mucosal lesions of leucoplastic appearance and gingival recessions. Regular consumption of khat is also significantly associated with the loss of prosthetic and / or striated restorations. Our results are confirmed by a Saudi study. Conclusion: Regular consumption of khat is significantly associated with a number of oral disorders. Future prevention campaigns should focus on the male population and the concomitant use of tobacco.
Nitrogen Fertilizer Programs for Organic Flue-Cured Tobacco (Nicotiana Tabacum L.) Seedling Production
Authors: Suchoff D.H. , Vann M.C. , McGinnis M. , Mason J.H. , Fisher L.
Published: February 2022

Certified organic flue-cured tobacco (Nicotiana tabacum L.) production has experienced significant expansion in the United States. Despite this expansion, there is very little information available that outlines organic nitrogen (N) programs for seedling production. To develop grower recommendations, research was conducted to evaluate the effects of a Peruvian seabird guano (SG), sodium nitrate (SN), or a combination of the two (SN_SG) in a float system on float water chemistry and seedling vigor. A conventional treatment (Conv; SQM Ultrasol Premium) was included for comparison. A greenhouse study was conducted twice between June 2016 and January 2017. Nitrogen fertilizer treatments were applied to tobacco float system water twice during the germination and growth of tobacco transplants. Float system water was collected every 5 days and analyzed for N forms, pH, dissolved oxygen, and bicarbonate. At the end of each experiment, transplant dimensions were measured and percent of usable plants collected. Float water bicarbonate concentration was <1 meq L−1 in treatments absent of SG for the duration of the study, but were in excess of 12 meq L−1 25 days after seeding (DAS) when SG was the exclusive N source. Despite high ammonium and bicarbonate concentrations with SG, neither factor negatively impacted seedling growth. Both SG and SN_SG produced as many usable plants as Conv; however, seedling height and diameter tended to be lower in SG compared to the other two treatments. No usable transplants were produced when SN was the sole fertility source, likely because of lack of nutrients other than N. Furthermore, many of the organic fertility products require biological activity to mineralize organic N to a plant-available form. This activity can have potentially detrimental outcomes on float system solution pH, dissolved oxygen, and bicarbonate levels.
Hypocapnia Stimuli-Responsive Engineered Exosomes Delivering miR-218 Facilitate Sciatic Nerve Regeneration
Authors: Wang Yingshuai , Yu Tao , Hu Feihu
Published: February 2022

Therapeutic strategies of microRNAs (miRNAs) and exosomes have been systematically explored as an enhancing application by paracrine and modulating cellular activity after internalization of recipient cells in vitro, and progressively developed to meet the requirements of peripheral nerve regeneration in vivo. However, how to obtain exosomes with superior properties and effectively deliver miRNAs becomes a key challenge. Hypocapnia environment might play unexpected outcomes in strengthening exosome function when culturing adipose-derived stem cells (ASCs). Previously, we discovered the intensive regulation of miR-218 on the differentiation of ASCs. In the present study, we analyzed the functional differences of secreted exosomes in response to hypocapnia stimulation, and explored the application in combination with miR-218 to facilitate sciatic nerve regeneration. Our results indicated that the delivery system of engineered exosomes derived from ASCs remarkably loads upregulated miR-218 and promotes cellular activity in the recipient cells (PC12 cells), and hypocapnia stimuli-responsive exosomes exhibit strengthening properties. Furthermore, in a sciatic nerve injury model, exosomes delivering miR-218 combined with engineered scaffold facilitated the regeneration of injured sciatic nerves. In the hypocapnia-stimulated exosome group, more encouraging promotion was revealed on the regeneration of motor and nerve fibers. Hypoc-miR-218-ASC exosomes are suggested as a promising cell-free strategy for peripheral nerve repair.
Identification of Subtypes and a Delayed Graft Function Predictive Signature Based on Ferroptosis in Renal Ischemia-Reperfusion Injury
Authors: Wei Xiangling , Deng Weiming , Dong Zhanwen , Xie Zhenwei , Zhang Jinhua , Wang Ruojiao , Zhang Rui , Na Ning , Zhou Yu
Published: February 2022

Renal ischemia-reperfusion injury (IRI) is an inevitable process in kidney transplantation, leading to acute kidney injury, delayed graft function (DGF), and even graft loss. Ferroptosis is an iron-dependent regulated cell death in various diseases including IRI. We aimed to identify subtypes of renal IRI and construct a robust DGF predictive signature based on ferroptosis-related genes (FRGs). A consensus clustering analysis was applied to identify ferroptosis-associated subtypes of 203 renal IRI samples in the GSE43974 dataset. The FRG-associated DGF predictive signature was constructed using the Least Absolute Shrinkage and Selection Operator (LASSO), and its robustness was further verified in the validation set GSE37838. The present study revealed two ferroptosis-related patient clusters (pBECN1 and pNF2 cluster) in renal IRI samples based on distinct expression patterns of BECN1 and NF2 gene clusters. Cluster pBECN1 was metabolically active and closely correlated with less DGF, while pNF2 was regarded as the metabolic exhausted subtype with higher incidence of DGF. Additionally, a six-gene (ATF3, SLC2A3, CXCL2, DDIT3, and ZFP36) ferroptosis-associated signature was constructed to predict occurrence of DGF in renal IRI patients and exhibited robust efficacy in both the training and validation sets. High-risk patients tended to have more infiltration of dendritic cells, macrophages, and T cells, and they had significantly enriched chemokine-related pathway, WNT/β-catenin signaling pathway, and allograft rejection. Patients with low risks of DGF were associated with ferroptosis-related pathways such as glutathione and fatty acid metabolism pathways. In conclusion, patient stratification with distinct metabolic activities based on ferroptosis may help distinguish patients who may respond to metabolic therapeutics. Moreover, the DGF predictive signature based on FRGs may guide advanced strategies toward prevention of DGF in the early stage.
Human Stool Preservation Impacts Taxonomic Profiles in 16S Metagenomics Studies
Authors: Plauzolles Anne , Toumi Eya , Bonnet Marion , Pénaranda Guillaume , Bidaut Ghislain , Chiche Laurent , Allardet-Servent Jérôme , Retornaz Frédérique , Goutorbe Benoit , Halfon Philippe
Published: February 2022

Microbiotas play critical roles in human health, yet in most cases scientists lack standardized and reproducible methods from collection and preservation of samples, as well as the choice of omic analysis, up to the data processing. To date, stool sample preservation remains a source of technological bias in metagenomic sequencing, despite newly developed storage solutions. Here, we conducted a comparative study of 10 storage methods for human stool over a 14-day period of storage at fluctuating temperatures. We first compared the performance of each stabilizer with observed bacterial composition variation within the same specimen. Then, we identified the nature of the observed variations to determine which bacterial populations were more impacted by the stabilizer. We found that DNA stabilizers display various stabilizing efficacies and affect the recovered bacterial profiles thus highlighting that some solutions are more performant in preserving the true gut microbial community. Furthermore, our results showed that the bias associated with the stabilizers can be linked to the phenotypical traits of the bacterial populations present in the studied samples. Although newly developed storage solutions have improved our capacity to stabilize stool microbial content over time, they are nevertheless not devoid of biases hence requiring the implantation of standard operating procedures. Acknowledging the biases and limitations of the implemented method is key to better interpret and support true associated microbiome patterns that will then lead us towards personalized medicine, in which the microbiota profile could constitute a reliable tool for clinical practice.
Bicuspid Aortic Valve Stenosis: From Pathophysiological Mechanism, Imaging Diagnosis, to Clinical Treatment Methods
Authors: Perrin Nils , Ibrahim Réda , Dürrleman Nicolas , Basmadjian Arsène , Leroux Lionel , Demers Philippe , Modine Thomas , Ben Ali Walid
Published: February 2022

Bicuspid aortic valve (BAV) is the most frequent congenital anomaly and has a natural evolution toward aortic regurgitation or stenosis due to the asymmetrical valve function associated with an evolutive ascending aortopathy. Several BAV classifications exist describing the presence and number of raphe, amount and location of calcium, and the symmetry of the functional cusps. The impact of BAV morphology on transcatheter aortic valve implantation (TAVI) outcomes still remains little investigated. Pivotal randomized trials comparing TAVI with surgery have excluded BAV until yet. However, data from registries and observational studies including highly selected patients have shown promising results of TAVI in BAV. With this review, we aimed at describing anatomical and pathophysiological characteristics of BAV, discussing the main aspects to assess diagnostic imaging modalities, and giving an overview of TAVI outcomes and technical considerations specific to BAV morphology.
Effectiveness and Safety of a Prolonged Hemodynamic Support by the IVAC2L System in Healthy and Cardiogenic Shock Pigs
Authors: Delmas Clément , Porterie Jean , Jourdan Géraldine , Lezoualc'h Frank , Arnaud Romain , Brun Stéphanie , Cavalerie Hugo , Blanc Grégoire , Marcheix Bertrand , Lairez Olivier , Verwaerde Patrick , Mialet-Perez Jeanne
Published: February 2022

Background

Mechanical circulatory supports are used in case of cardiogenic shock (CS) refractory to conventional therapy. Several devices can be employed, but are limited by their availability, benefit risk-ratio, and/or cost.

Aims

To investigate the feasibility, safety, and effectiveness of a long-term support by a new available device (IVAC2L) in pigs.

Methods

Experiments were carried out in male pigs, divided into healthy (n = 6) or ischemic CS (n = 4) groups for a median support time of 34 and 12 h, respectively. IVAC2L was implanted under fluoroscopic and TTE guidance under general anesthesia. CS was induced by surgical ligation of the left anterior descending artery. An ipsilateral lower limb reperfusion was created with the Solopath® system. Reperfusion was started after 1 h of support in healthy pigs and upon IVAC2L insertion in CS pigs. Hemodynamic and biological parameters were monitored before and during the whole period of support in each group.

Results

Occurrence of an ipsilateral lower limb ischemia was systematic in healthy and CS pigs in a few minutes after IVAC2L implantation, and could be reversed by the arterial reperfusion, as demonstrated by distal transcutaneous pressure in oxygen (TcPO2) and lactate normalization. IVAC2L support decreased pulmonary capillary wedge pressure (PCWP) (15.3 ± 0.3 vs. 7.5 ± 0.9 mmHg, p < 0.001), increased systolic blood pressure (SBP) (70 ± 4.5 vs. 101.3 ± 3.1 mmHg, p < 0.01), and cardiac output (CO) (4.0 ± 0.3 vs. 5.2 ± 0.6 l/min, p < 0.05) in CS pigs; at CS onset and after 12 h of support, without effects on heart rate or pulmonary artery pressure (PAP). Non-sustained ventricular arrhythmias were frequent at implantation (50%). A non-significant hemolysis was observed under support in CS pigs. Bleedings were frequent at the insertion and/or operating sites (30%).

Conclusion

Long-term support by IVAC2L is feasible and associated with a significant hemodynamic improvement in a porcine model. These preclinical data open the door for a study of IVAC2L in human ischemic CS, keeping in mind the need for systematic reperfusion of the lower limb and the associated risk of bleeding.
Crustal S-Wave Velocity Structure Beneath the Northwestern Bohemian Massif, Central Europe, Revealed by the Inversion of Multimodal Ambient Noise Dispersion Curves
Authors: Ma Qingbo , Pan Lei , Wang Jian-nan , Yang Zhentao , Chen Xiaofei
Published: February 2022

The northwestern Bohemian Massif and adjacent areas are a tectonically active region associated with complex geodynamic activities, that manifest as Quaternary volcanism, earthquake swarms in the upper and middle crust, degassing of CO2, and crustal fluid migration. The intricate tectonic evolution and activities of this region reflect the complexity of the crustal structure therein. However, the crustal models derived from previous studies in this area offer different, even contradictory information regarding the existence of a mid-crustal low-velocity zone (LVZ). In this study, we apply the frequency-Bessel transform (F-J) method to extract the fundamental-mode and up to five higher-mode Rayleigh wave dispersion curves from ambient seismic noise data recorded in the study area and perform multimodal ambient noise dispersion curves inversion. The addition of higher-mode dispersion curves enhances the vertical resolution of the velocity structure inversion results. Our models support the view that the general S-wave velocity level of the crust is high within the study area. We detect two S-wave LVZs beneath the study area that are distributed mainly in the middle crust rather than the lower crust, and these LVZs are separated by a high-velocity zone. Considering the results of previous studies in the area, we infer that these S-wave LVZs may be the consequence of crustal fluids, plastic deformation and even partial melting of the felsic middle crust at relatively high crustal temperatures. Furthermore, these S-wave LVZs could be responsible for the origin and foci depth distribution of earthquake swarms. S-wave low-velocity anomalies are also observed in the uppermost mantle beneath the study area. These S-wave models based on the joint inversion of multimodal dispersion curves can provide new references for understanding the tectonic activity and geodynamic evolution of the northwestern Bohemian Massif and adjacent areas.
Dissecting the Association of Apolipoprotein E Gene Polymorphisms With Type 2 Diabetes Mellitus and Coronary Artery Disease
Authors: Wu Lei , Zhang Yan , Zhao Hong , Rong Guodong , Huang Peijun , Wang Fang , Xu Ting
Published: February 2022

Background

Apolipoprotein E (APOE) gene mediates lipoprotein clearance and is one of the most studied candidate genes for type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). This study was performed to determine the association between APOE polymorphisms and T2DM with and without CAD, and its effect on plasma lipid levels in a Chinese population.

Methods

A total of 1,414 subjects involving 869 patients and 545 health individuals were recruited. These patients were categorized into three distinct groups: 264 in T2DM group, 401 in CAD group, and 204 in T2DM+CAD group. Logistic regression analysis was used to obtain odds ratio (OR) and 95% confidence interval (CI) in predicting the risk probability of APOE. Besides, a meta-analysis was preformed to integrate an evaluation index to evaluate their associations.

Results

Genotype frequency ratio of genotype ϵ3/4 and allele ϵ4 among the CAD patients with or without T2DM was obviously increased. Compared with ϵ3/3 genotype, the ϵ3/4 genotype had a significant increased risk of CAD (adjusted OR = 1.90, 95% CI = 1.30–2.77) and T2DM+CAD (adjusted OR = 1.95, 95% CI = 1.24–3.08). In the meta-analysis, four studies were included and provided a strong evidence for the APOE ϵ4 mutation elevating the risk of CAD in patients with T2DM (ϵ3/ϵ4+ϵ4/ϵ4 vs. ϵ3/ϵ3, OR = 1.51, 95% CI = 1.13–2.02). In the T2DM group, the plasma levels of low-density lipoprotein cholesterol (LDL-C) showed significant difference among the three APOE isoforms. The high-density lipoprotein cholesterol (HDL-C) levels of CAD patients with ϵ4-bearing genotypes were lower than those with ϵ3/3 genotype.

Conclusions

Our results indicate that APOE gene polymorphisms are related to CAD with or without T2DM and have influence on lipid profiles in both T2DM and CAD patients.
More Environmental Sustainability Routing and Energy Management for All Electric Ships
Authors: Pan Xuewei , Zhu Xingzhou , Zhao Fei
Published: February 2022

With the popularity of the electrification of marine transportation, strategic energy-saving and environment-friendly management is gaining more attention recently. This paper proposes a novel coordinated navigation routing and power generation scheduling model, which aims at making a compromise between investment cost, operation cost, and greenhouse gas emissions under the distributional robust ambiguity of photovoltaic. A maritime hybrid energy configuration that combines diesel generator (DG), battery energy storage system (BESS), fuel cell (FC), photovoltaic (PV), and the cold-ironing connection is presented with a real-world navigation routine from Dalian to Singapore, and the optimization problem is solved through a bi-level tri-objective differential evolution algorithm, where navigation parameters, ESS and FC capacity and weight between operation cost and emission functions, are optimized in the upper level and specific power generation scheduling is settled in the lower level. Six case studies are conducted to verify its effectiveness and accuracy, and the simulation results demonstrate the proposed method can further reduce the operation cost while minimizing air contamination.