bluuebunny/crossref_metadata_2025 huggingface dataset:
Opportunities and Challenges in MOCVD of βGa2O3 for Power Electronic Devices
Authors: Mastro M. A. , Hite J. K. , Eddy C. R. , Tadjer M. J. , Pearton S. J. , Ren F. , Kim J.
Published: October 2019

Recent breakthroughs in bulk crystal growth of β-Ga2O3 by the edge-defined film-fed technique has led to the commercialization of large-area β-Ga2O3 substrates. Standard epitaxy approaches are being utilized to develop various thin-film β-Ga2O3 based devices including lateral transistors. This article will discuss the challenges for metal organic chemical vapor deposition (MOCVD) of β-Ga2O3 and the design criteria for use of this material system in power electronic device structures.
Modeling and Simulation of Quasi-Ballistic III-Nitride Transistors for RF and Digital Applications
Authors: Li Kexin , Rakheja Shaloo
Published: October 2019

This paper presents a self-consistent analytic model to describe the current-voltage (I-V) and charge-voltage (Q-V) behavior of quasi-ballistic III-nitride transistors. We focus on two types of transistor geometries: (i) high electron mobility transistors (HEMTs) suitable for radio frequency (RF) applications and (ii) nanowire field-effect transistors (FETs) for digital applications. Our core model is based on Landauer transport theory which is combined with the calculation of charge density and velocity of charges at the top-of-the-barrier in the transistor. The effect of extrinsic device features, such as the nonlinearity of access regions and Joule heating at high currents, are included in the static I-V model. In the case of the dynamic Q-V model, we calculate intrinsic terminal charges by approximating the solution of the 2D Poisson equation in the channel over a broad bias range. The effect of fringing capacitances, prominently inner-fringing capacitance that varies nonlinearly with the gate bias, is included in our Q-V model. We amend the model electrostatics and the description of source/drain rectifying contacts in our core model to represent the I-V characteristics of III-nitride nanowire FETs. The model shows excellent match against experimentally and numerically measured characteristics of GaN transistors with gate lengths ranging from 42 nm to 274 nm. With only 38 input parameters, most of which are extracted based on straightforward device characterization, our model can be used for device-circuit co-design and optimization using a standard hierarchical circuit simulator.
On Steinitz-like properties in amalgamated algebras along an ideal
Authors: El Maalmi Mourad , Mouanis Hakima
Published: October 2019

Let [Formula: see text] be a ring homomorphism, [Formula: see text] be an ideal of [Formula: see text] and [Formula: see text] the amalgamation of [Formula: see text] with [Formula: see text] along [Formula: see text] with respect to [Formula: see text]. In this paper, we provide necessary and sufficient conditions for [Formula: see text] to be a Steinitz ring, semi-Steinitz ring, and weakly semi-Steinitz. Then we construct new original examples of weakly semi-Steinitz rings which are not semi-Steinitz rings and semi-Steinitz rings which are not Steinitz rings.
Quantum circuits for calculating the squared sum of the inner product of quantum states and its application
Authors: Li Panchi , Guo Jiahui , Wang Bing , Hao Mengqi
Published: October 2019

In this paper, we propose a quantum circuit for calculating the squared sum of the inner product of quantum states. The circuit is designed by the multi-qubits controlled-swapping gates, in which the initial state of each control qubit is [Formula: see text] and they are in the equilibrium superposition state after passing through some Hadamard gates. Then, according to the control rules, each basis state in the superposition state controls the corresponding quantum states pair to swap. Finally, the Hadamard gates are applied to the control qubits again, and the squared sum of the inner product of many pairs of quantum states can be obtained simultaneously by measuring only one control qubit. We investigate the application of this method in quantum images matching on a classical computer, and the experimental results verify the correctness of the proposed method.
Measurement Development and Evaluation
Authors: Zickar Michael J.
Published: October 2019

Psychological measurement is at the heart of organizational research. I review recent practices in the area of measurement development and evaluation, detailing best practice recommendations in both of these areas. Throughout the article, I stress that theory and discovery should guide scale development and that statistical tools, although they play a crucial role, should be chosen to best evaluate the theoretical underpinnings of scales as well as to best promote discovery. I review all stages of scale development and evaluation, ranging from construct specification and item writing, to scale revision. Different statistical frameworks are considered, including classical test theory, exploratory factor analysis, confirmatory factor analysis, and item response theory, and I encourage readers to consider how best to use each of these tools to capitalize on each approach's particular strengths.
Influence of Estrogen Receptor Alpha Polymorphism on Bone Mineral Density in Iranian Children
Authors: Montazeri-Najafabady Nima , Dabbaghmanesh Mohammad Hossein , Mohammadian Amiri Rajeeh , Mirzai Zahra
Published: October 2019

Background: Bone mass acquisition in childhood is directly linked to adult bone mineral density (BMD) and fracture risk. BMD is a heritable trait, more than 70% of its variability among a population is affected by genetic factors. Objectives: In the present study, we wanted to investigate the association between estrogen receptor alpha (ESR1) polymorphisms, PvuII (rs2234693) and XbaI (rs9340799), and bone area, bone mineral content (BMC), and BMD of the lumbar spine, femoral neck, and also of the total body less the head in Iranian children. Methods: The ESR1 gene PvuII and XbaI genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. Bone area, BMC, BMD, and bone mineral apparent density (BMAD) were assessed by dual-energy X-ray absorptiometry (DEXA). Linear regression was carried out to examine the effects of the ESR1 (PvuII and XbaI) polymorphisms on DEXA outputs when adjusted for confounding factors (i.e., age, sex, BMI, and pubertal stage) in 3 models. Results: ESR1 (PvuII) gene polymorphisms (CT vs. CC) showed significant effects on the BMC of the total body less the head in all 3 models. For ESR1 (XbaI), individuals with the AG genotype had higher lumbar spine BMD and lumbar spine BMAD compared to other genotypes. Conclusions: It seems that the PvuII and XbaI polymorphisms of ESR1 could be associated with BMC and BMD variation in Iranian children and adolescents.
Design and Baseline Characteristics of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease Trial
Authors: Bakris George L. , Agarwal Rajiv , Anker Stefan D. , Pitt Bertram , Ruilope Luis M. , Nowack Christina , Kolkhof Peter , Ferreira Anna C. , Schloemer Patrick , Filippatos Gerasimos ,   on behalf of the FIDELIO-DKD study investigators
Published: October 2019

Background: Among diabetics, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality, and progression of their underlying disease. Finerenone is a novel, non-steroidal, selective mineralocorticoid-receptor antagonist which has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD), while revealing only a low risk of hyperkalemia. However, the effect of finerenone on renal and CV outcomes has not been investigated in long-term trials yet. Methods: The Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease ­(FIDELIO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important renal and CV outcomes in T2D patients with CKD. FIDELIO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 5.5 years. FIDELIO-DKD randomized 5,734 patients with an estimated glomerular filtration rate (eGFR) ≥25–<75 mL/min/1.73 m2 and albuminuria (urinary albumin-to-creatinine ratio ≥30–≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of kidney failure, a sustained decrease of eGFR ≥40% from baseline over at least 4 weeks, or renal death. Conclusion: FIDELIO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of renal and CV events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Prevalence, Characteristics and Endoscopic Management of Gastric Premalignant Lesions in France
Authors: Chapelle Nicolas , Péron Matthieu , Mosnier Jean-François , Quénéhervé Lucille , Coron Emmanuel , Bourget Alice , Cauchin Estelle , Touchefeu Yann , Matysiak-Budnik Tamara
Published: October 2019

Introduction: Surveillance of gastric precancerous lesions (GPL) is recommended, but the data on their clinical and endoscopic management in a “real-life” practice are limited. Our aim was to study the modalities of endoscopic management of patients with GPL in France. Design: All the patients diagnosed with GPL in our center between 2000 and 2015 were grouped and analyzed according to the most severe GPL found, in the following order: atrophic gastritis only (AG), intestinal metaplasia (IM), low grade dysplasia (LGD), high grade dysplasia (HGD). Results: Out of 16,764 patients having undergone upper endoscopy with gastric biopsies, 507 were identified with GPL (detection rate 3.2%). Overall, Helicobacter pylori infection was found in 41% of patients. IM was by far the most frequently found lesion (79%), followed by LGD (17%), HGD (2%), and AG only (2%). H. pylori infection rate was decreasing, while the age of the patients was increasing, together with the increasing severity of GPL (p = 0.005). Only 28% of the patients had at least one follow-up endoscopy. No correlation was found between the endoscopist’s appreciation of the mucosa and histological results. Conclusion: In France, GPL can be expected in about 3% of patients undergoing upper endoscopy with gastric biopsies for any reason. The correlation between the endoscopic evaluation and histology is poor. Spreading of published guidelines should improve the management of patients with GPL in the future.
Trends in Cardiovascular Disease Morbidity and Mortality in American Indians Over 25 Years: The Strong Heart Study
Authors: Muller Clemma J. , Noonan Carolyn J. , MacLehose Richard F. , Stoner Julie A. , Lee Elisa T. , Best Lyle G. , Calhoun Darren , Jolly Stacey E. , Devereux Richard B. , Howard Barbara V.
Published: October 2019

Background

American Indians experience high rates of cardiovascular disease. We evaluated whether cardiovascular disease incidence, mortality, and prevalence changed over 25 years among American Indians aged 30 to 85.

Methods and Results

The SHS (Strong Heart Study) and SHFS (Strong Heart Family Study) are prospective studies of cardiovascular disease in American Indians. Participants enrolled in 1989 to 1990 or 2000 to 2003 with birth years from 1915 to 1984 were followed for cardiovascular disease events through 2013. We used Poisson regression to analyze data for 5627 individuals aged 30 to 85 years during follow‐up. Outcomes reflect change in age‐specific cardiovascular disease incidence, mortality, and prevalence, stratified by sex. To illustrate generational change, 5‐year relative risk compared most recent birth years for ages 45, 55, 65, and 75 to same‐aged counterparts born 1 generation (23–25 years) earlier. At all ages, cardiovascular disease incidence was lower for people with more recent birth years. Cardiovascular disease mortality declined consistently among men, while prevalence declined among women. Generational comparisons were similar for women aged 45 to 75 (relative risk, 0.39–0.46), but among men magnitudes strengthened from age 45 to 75 (relative risk, 0.91–0.39). For cardiovascular disease mortality, risk was lower in the most recent versus the earliest birth years for women (relative risk, 0.56–0.83) and men (relative risk, 0.40–0.54), but results for women were inconclusive.

Conclusions

Cardiovascular disease incidence declined over a generation in an American Indian cohort. Mortality declined more for men, while prevalence declined more for women. These trends might reflect more improvement in case survival among men compared with women.
Proximity to wastewater effluent alters behaviour in bluegill sunfish (Lepomis machrochirus)
Authors: McLean Adrienne R. , Du Sherry N.N. , Choi Jasmine A. , Culbert Brett M. , McCallum Erin S. , Scott Graham R. , Balshine Sigal
Published: October 2019

Wastewater from municipal, agricultural and industrial sources is a pervasive contaminant of aquatic environments worldwide. Most studies that have investigated the negative impacts of wastewater on organisms have taken place in a laboratory. Here, we tested whether fish behaviour is altered by exposure to environmentally relevant concentrations of wastewater effluent in the field. We caged bluegill sunfish (Lepomis macrochirus) for 28 days at two sites downstream (adjacent to and 870 m) from a wastewater treatment plant and at a reference site without wastewater inputs. We found that exposed fish had a dampened response to simulated predation compared to unexposed fish, suggesting that fish may be at greater risk of predation after exposure to wastewater effluent. Fish held at the different sites did not differ in activity and exploration. Our results suggest that predator avoidance may be impaired in fish exposed to wastewater effluent, which could have detrimental implications for aquatic communities.
Misty Transcendence and the Irony of (Dis)belief
Authors: Barrett Nick
Published: October 2019

In the late 1970s and ’80s, a new generation of Chinese poets emerged with a powerful critique of the state’s aggressive political reforms. After the 1976 Tiananmen Square incident, the Bejing poet Zaho Zhenkai (known as Bei Dao) wrote a startling poem titled “The Answer” about his refusal to believe in the unquestioned ultimacy of China’s worldview. Bei Dao’s unique style of poetry helped readers make new associations that were otherwise inaccessible to them. This article examines Bei Dao’s use of metaphor in “The Answer” through the lens of the aesthetic philosopher Lambert Zuidervaart and suggests that the poet’s use of self-controverting metaphors makes an absent reality graspable and present. The article then considers the role of public theology as it listens to the witness of the poet’s bewildering evocation of accessing “the real” through disbelief. In consideration of Herman Bavinck’s essay On Contemporary Ethics, this article suggests that theologians (and religious practitioners) should resist the temptation to control the artist’s expression even when it limps with narcissism and moral deficiency. Instead, the theologian (and the church) should fight alongside the artist in helping them to share their staggering vision or, in Bei Dao’s case, the transcendent power of resiliency sustained by the shadows of the dead. This article aims to generate a fruitful dialogue between Bei Dao and the Reformed theological tradition that underscores the uncanny importance of disbelief as an alternative strategy for cultural transformation and faithful proclamation.
The Noble Enemy: Bravery, Surrender and Suicide in the First Sino-Japanese War
Authors: O’Reilly Sean
Published: October 2019

What can be learned from the now largely forgotten first Sino-Japanese War (1894-95) about concepts like the heroism of surrender? I show that Japanese depictions, far from being universally contemptuous, treated their main opponent, the commander of the Chinese Beiyang fleet, Admiral Ding Ruchang, with great respect before, during, and even after the war despite his surrender. Why? I use accounts by observers and Ding’s own letters to scrutinize the enduring popularity of his posthumous image in Japan versus China. I argue that Ding showed neither strategic brilliance nor formidability as an opponent. This means he does not fit the “nobility of failure” concept, remaining an anomalous outlier for provoking such hero-worship in Japan despite his mediocre wartime performance. Overall, how Ding and the Beiyang Fleet were treated in popular Japanese accounts suggests that Japanese attitudes towards concepts such as “bravery,” “surrender,” and “suicide” were in flux in the 1890s.
The Canadian Arctic Weather Science Project: Introduction to the Iqaluit Site
Authors: Joe Paul , Melo Stella , Burrows William R. , Casati Barbara , Crawford Robert W. , Deghan Armin , Gascon Gabrielle , Mariani Zen , Milbrandt Jason , Strawbridge Kevin
Published: October 2019

The goal of the Canadian Arctic Weather Science (CAWS) project is to conduct research into the future operational monitoring and forecasting programs of Environment and Climate Change Canada in the Arctic where increased economic and recreational activities are expected with enhanced transportation and search and rescue requirements. Due to cost, remoteness and vast geographical coverage, the future monitoring concept includes a combination of space-based observations, sparse in situ surface measurements, and advanced reference sites. A prototype reference site has been established at Iqaluit, Nunavut (63°45'N, 68°33'W), that includes a Ka-band radar, water vapor lidars (both in-house and commercial versions), multiple Doppler lidars, ceilometers, radiation flux, and precipitation sensors. The scope of the project includes understanding of the polar processes, evaluating new technologies, validation of satellite products, validation of numerical weather prediction systems, development of warning products, and communication of their risk to a variety of users. This contribution will provide an overview of the CAWS project to show some preliminary results and to encourage collaborations.
A New Brief Scale to Measure Optimism
Authors: Garcia Cadena Cirilo H. , Daniel González Leopoldo , Valle de la O Adrián
Published: October 2019

This research was done to find if using maximum likelihood could reduce the Interactive Optimism Scale-Garcia to a new valid and reliable shorter version. There were 502 adults: 263 women and 239 men ( Mage = 34.67, SD = 12.27). It was used in confirmatory factor analysis. A four-item scale is obtained, having excellent goodness of fit: [χ2/ df = .609, GFI (Jöreskog and Sörbom’s Goodness-of-Fit Index) = .999, NFI (Normed Fit Index) = .999, CFI (Bentler’s Comparative Fit Index) = 1.000, RMSEA (Steiger–Lind root mean square error of approximation) = .000 (90% CI = .0001, .077); SRMR (standardized root mean square residual) = .007], as well as factorial invariance across sexes; the scale has good internal consistency (ω = .869, α = .858, ordinal α = .906). Brief Interactive Optimism Scale-G correlates significantly with self-esteem ( r = .779, p < . 01, 95% CI [.816, .736]), depression ( r = −.810, p < .01, 95% CI [.843, .772]), and psychopathy ( r = −.670, p < . 01, 95% CI [.723, .611]). In conclusion, Brief Interactive Optimism Scale-G is a good option for measuring optimism in Mexicans.
Abnormal pulmonary function tests are associated with prolonged ventilation and risk of complications following elective cardiac surgery
Authors: Reddi Benjamin AJ , Johnston Sonya D , Bart Stanley , Chan Justin CY , Finnis Mark
Published: October 2019

Elective cardiac surgery accounts for a significant proportion of perioperative resource allocation in Australasia. Preoperative pulmonary function testing (PFT) is routinely undertaken in some centres to identify patients who may require prolonged ventilation and intensive care unit (ICU) stay, although there are currently no data supporting this practice. Routine PFT places a burden on respiratory diagnostic laboratories, is inconvenient to patients and may delay surgery. We aimed to identify whether PFT parameters identify patients requiring prolonged mechanical ventilation after elective cardiac surgery. Adult patients admitted to the Royal Adelaide Hospital ICU following elective cardiac surgery between July 2013 and December 2017 were identified retrospectively from the local ICU database. Preoperative PFT and operative and postoperative outcome data were retrieved from local databases, and multivariable logistic regression was undertaken to identify which PFT variables were associated with prolonged mechanical ventilation. PFT data were available for 835/1139 (73%) elective cardiac surgical cases. The best independent predictors of prolonged mechanical ventilation were post-bronchodilator forced vital capacity (FVC) and single-breath diffusing capacity for carbon monoxide (DLCO). Patients with FVC <80% predicted and DLCO <60% predicted had an odds ratio for prolonged postoperative ventilation of 7.5 (95% confidence intervals 3.6–15.6; P < 0.001). The area under the receiver operating characteristic curve derived from this model was 0.68. Abnormal PFT results were associated with prolonged postoperative mechanical ventilation. A PFT-based prediction tool does not accurately predict individual patient outcome but identifies a cohort of patients at higher risk of requiring prolonged ventilation, potentially informing ICU resource allocation and surgical planning.
“Like, Share, Comment,” and Learn: Transformative Learning in Online Anti-Trump Resistance Communities
Authors: Schroeder Stephanie , Currin Elizabeth , Washington Elizabeth , Curcio Rachelle , Lundgren Lisa
Published: October 2019

This article explores adult participation in online social media resistance groups that formed after the 2016 U.S. presidential election (e.g., Indivisible), why individuals participate, and how their views of citizenship are transformed as a result of their participation. Reporting on demographic and open-ended qualitative survey data, this study describes the demographics of participants and employs inductive and deductive coding as analytic methods. Making use of transformative learning as a metatheory and coding with transformative learning typologies in mind, this article illustrates the range of learning outcomes experienced by participants. Our findings indicate the educative potential of online resistance groups, as participants deepened their understandings of democracy, grew more discerning about information shared online, developed confidence to take action, and saw themselves as newly positioned in democracy, connected and capable of making change.
Biodegradable hypoxia biomimicry microspheres for bone tissue regeneration
Authors: Hadidi Lina , Constantin Justine , Dalisson Benjamin , Vieira Daniela , Drager Justin , Harvey Edward , Merle Geraldine
Published: October 2019

The iron chelator deferoxamine is a hypoxia biomimicry and has received interest as a potential therapeutic in tissue engineering and regenerative medicine. Recently, local injection of this iron chelator deferoxamine has proven to increase bone healing through the activation of the hypoxia-inducible factor-1 signaling pathway that augments angiogenesis and osteogenesis. Repeated injections of deferoxamine are required to achieve local therapeutic levels at fracture site. To achieve local therapeutic levels at fracture site without the use of multiples injections and associated pain and infection issues, we designed and prepared polymeric microspheres made of polycaprolactone and poly(ethylene oxide), in which deferoxamine was encapsulated, via a melting process. The application of this process has enabled to obtain spheres of different poly(ethylene oxide) concentrations for optimizing the drug release rate. The effective local release carrier offers a predetermined rate that can mimic the effect of repeated deferoxamine injections over a 14-day period to selectively stimulate bone repair and thus improve the biological performance to the point where ideally synthetics begin to challenge autograft dominance as the bone replacement of choice.
Phenomenology for the Holistic Nurse Researcher: Underpinnings of Descriptive and Interpretive Traditions
Authors: Patton Cheryl M.
Published: October 2019

Phenomenological research is increasing in popularity in nursing research for good reason. The qualitative research method allows an in-depth exploration of patient lived experience. This knowledge has the potential to enhance quality of holistic patient care. To undertake this method of inquiry, however, it is imperative that holistic nurse researchers understand the philosophical underpinnings of the method and are familiar with the two major types of phenomenology in order to approach the study in a scholarly manner. The purpose of this article is to explicate the method’s historical roots of phenomenology, its evolution, its two major traditions and their differences, and some of the specialized terminology unique to phenomenology’s jargon so that their studies can contribute to sound nursing science and complete patient care.
Variation in the Utilization of Postoperative Computed Tomography for Patients With Nonsyndromic Craniosynostosis: A National Claims Analysis
Authors: Makar Katelyn G. , Gunaseelan Vidhya , Waljee Jennifer , Vercler Christian J. , Buchman Steven R.
Published: October 2019

Objective:

Routine postoperative computed tomography (CT) imaging in nonsyndromic craniosynostosis remains controversial due to the hazards of radiation exposure. The extent to which postoperative head CTs are performed remains unknown. Therefore, we sought to measure the use of postoperative CTs in this population.

Design:

The authors reviewed insurance claims from OptumInsight, using Current Procedural Terminology codes to identify procedures and postoperative imaging. Multilevel logistic regression was used to describe the odds of undergoing postoperative CTs, adjusting for patient and provider covariates.

Participants:

Craniosynostosis patients who underwent reconstruction between 2001 and 2017 were reviewed. Patients older than 5 years at surgery, postoperative lengths of stay >15 days, syndromic diagnoses, operative complications within 30 days of surgery, and cranial bone grafting merited exclusion.

Main Outcome Measure:

Odds of postoperative head CTs after cranial vault reconstruction.

Results:

In this cohort (n = 1150), 326 (28.4%) patients underwent postoperative head CTs. The number of CTs ranged from 0 to 14. Older age at surgery (odds ratio [OR]: 1.32, P = .002), increasing years of follow-up (OR: 1.12, P < .001), and increasing comorbidities (OR: 1.21, P = .017) were associated with postoperative CTs. After adjusting for patient factors, provider factors accounted for 31.3% of variation in imaging.

Conclusions:

Over a quarter of patients underwent head CTs following reconstruction, and provider factors accounted for a large percentage of the variation. Given the risks of radiation, neurosurgeons and craniofacial surgeons face a critical need to establish postoperative imaging protocols to reduce unnecessary imaging in these vulnerable patients.
Feline abdominal ultrasonography: What’s normal? What’s abnormal? The diseased gastrointestinal tract
Authors: Griffin Sally
Published: October 2019

Practical relevance:

Abdominal ultrasound plays a vital role in the diagnostic work-up of many cats presenting to general and specialist practitioners. B-mode ultrasonography is likely the most widely used modality for imaging the gastrointestinal (GI) tract in cats and it can help in the diagnosis of GI masses, foreign bodies and disorders of the ileocaecocolic junction.

Clinical challenges:

Despite ultrasonography being a commonly used modality, many practitioners are not comfortable performing an ultrasound examination or interpreting the resulting images. Even differentiating between normal variations and pathological changes can be challenging for all but the most experienced. For example, while for inflammatory conditions of the feline GI tract changes are frequently identified on ultrasound, there may occasionally be no changes to the appearance of the intestine; hence a ‘normal’ ultrasound does not exclude the possibility of inflammatory disease.

Aim:

This review, part of an occasional series on feline abdominal ultrasonography, describes the appearance of a range of conditions that affect the feline GI tract; the normal GI tract is addressed in an accompanying article in this issue of JFMS. Aimed at general practitioners who wish to improve their knowledge and confidence in feline abdominal ultrasound, this review is accompanied by high-resolution images and videos available online as supplementary material.

Equipment:

Ultrasound facilities are readily available to most practitioners, although use of ultrasonography as a diagnostic tool is highly dependent on operator experience.

Evidence base:

Information provided in this article is drawn from the published literature and the author’s own clinical experience.
Black Screens: A Visual Essay on Mobile Screens in the City
Authors: Gómez Cruz Edgar
Published: October 2019

This visual essay, along with the Black Screens photographic series upon which it is based, has two aims. On the one hand, it is intended as a visual exploration of the increasingly central role that mobile phones have in our everyday lives. In a time when digital technologies are ubiquitous in urban settings of developed countries, the images reflect, visually, on what this pervasiveness looks like. The other aim is to present suggestions of how methods borrowed and/or inspired by art and street photography could potentially expand the toolkit of ethnographic inquiry.
Prospective increase in the heat pump’s efficiency through arrangement in a three-temperature system
Authors: Stejskal Tomáš , Svetlík Jozef , Demeč Peter , Žilinský Adam , Kováč Juraj
Published: October 2019

Analysis of three-temperature heating system has revealed the apparent advantages and disadvantages that the combination of thermodynamic systems has in future development with respect to environmental and economic issues. Three-temperature heating systems consist of a heat engine and a heat pump, thus enabling maximum use of the primary thermal source for heating buildings. It seems that the combination of a Stirling engine, or a similar heat drive, with a heat pump is suitable. In order to analyse the effectiveness of such a system, a comprehensive calculation procedure is used as follows: its basis lies in accounting for all types of energy and their relationship to the original natural resource. The present study aims to point out that the combination of a Stirling engine and a heat pump is a useful solution due to the fact that it has the most favourable resultant economic impact in comparison to the use of a diesel, four-stroke gas or the most commonly used electric drive.
Brentuximab vedotin in the treatment of CD30+ PTCL
Authors: Barta Stefan K. , Gong Jerald Z. , Porcu Pierluigi
Published: October 2019

In this timely Blood Spotlight, Barta et al summarize for the practicing hematologist the strengths and limitations of current data on brentuximab vedotin–based treatment in peripheral T-cell lymphoma (PTCL).
Effect of RANS Turbulence Model on Aerodynamic Behavior of Trains in Crosswind
Authors: Li Tian , Qin Deng , Zhang Jiye
Published: October 2019

The numerical simulation based on Reynolds time-averaged equation is one of the approved methods to evaluate the aerodynamic performance of trains in crosswind. However, there are several turbulence models, trains may present different aerodynamic performances in crosswind using different turbulence models. In order to select the most suitable turbulence model, the inter-city express 2 (ICE2) model is chosen as a research object, 6 different turbulence models are used to simulate the flow characteristics, surface pressure and aerodynamic forces of the train in crosswind, respectively. 6 turbulence models are the standard k-ε, Renormalization Group (RNG) k-ε, Realizable k-ε, Shear Stress Transport (SST) k-ω, standard k-ω and Spalart–Allmaras (SPA), respectively. The numerical results and the wind tunnel experimental data are compared. The results show that the most accurate model for predicting the surface pressure of the train is SST k-ω, followed by Realizable k-ε. Compared with the experimental result, the error of the side force coefficient obtained by SST k-ω and Realizable k-ε turbulence model is less than 1 %. The most accurate prediction for the lift force coefficient is achieved by SST k-ω, followed by RNG k-ε. By comparing 6 different turbulence models, the SST k-ω model is most suitable for the numerical simulation of the aerodynamic behavior of trains in crosswind.
Identification of CBL and CIPK gene families and functional characterization of CaCIPK1 under Phytophthora capsici in pepper (Capsicum annuum L.)
Authors: Ma Xiao , Gai Wen-Xian , Qiao Yi-Ming , Ali Muhammad , Wei Ai-Min , Luo De-Xu , Li Quan-Hui , Gong Zhen-Hui
Published: October 2019

Background

Calcineurin B-like proteins (CBLs) are major Ca2+sensors that interact with CBL-interacting protein kinases (CIPKs) to regulate growth and development in plants. The CBL-CIPK network is involved in stress response, yet little is understood on how CBL-CIPK function in pepper (Capsicum annuumL.), a staple vegetable crop that is threatened by biotic and abiotic stressors.

Results

In the present study, nineCaCBLand 26CaCIPKgenes were identified in pepper and the genes were named based on their chromosomal order. Phylogenetic and structural analysis revealed thatCaCBLandCaCIPKgenes clustered in four and five groups, respectively. Quantitative real-time PCR (qRT-PCR) assays showed thatCaCBLandCaCIPKgenes were constitutively expressed in different tissues, and their expression patterns were altered when the plant was exposed toPhytophthora capsici, salt and osmotic stress.CaCIPK1expression changed in response to stress, including exposure toP. capsici, NaCl, mannitol, salicylic acid (SA), methyl jasmonate (MeJA), abscisic acid (ABA), ethylene (ETH), cold and heat stress. Knocking downCaCIPK1expression increased the susceptibility of pepper toP. capsici, reduced root activity, and altered the expression of defense related genes. Transient overexpression ofCaCIPK1enhanced H2O2accumulation, cell death, and expression of genes involved in defense.

Conclusions

NineCaCBLand 26CaCIPKgenes were identified in the pepper genome, and the expression of mostCaCBLandCaCIPKgenes were altered when the plant was exposed to stress. In particular, we found thatCaCIPK1is mediates the pepper plant’s defense againstP. capsici. These results provide the groundwork for further functional characterization ofCaCBLandCaCIPKgenes in pepper.
Exploring gene networks in two sunflower lines with contrasting leaf senescence phenotype using a system biology approach
Authors: Moschen Sebastián , Marino Johanna , Nicosia Salvador , Higgins Janet , Alseekh Saleh , Astigueta Francisco , Bengoa Luoni Sofia , Rivarola Máximo , Fernie Alisdair R. , Blanchet Nicolas , Langlade Nicolas B. , Paniego Norma , Fernández Paula , Heinz Ruth A.
Published: October 2019

Background

Leaf senescence is a complex process, controlled by multiple genetic and environmental variables. In sunflower, leaf senescence is triggered abruptly following anthesis thereby limiting the capacity of plants to keep their green leaf area during grain filling, which subsequently has a strong impact on crop yield. Recently, we performed a selection of contrasting sunflower inbred lines for the progress of leaf senescence through a physiological, cytological and molecular approach. Here we present a large scale transcriptomic analysis using RNA-seq and its integration with metabolic profiles for two contrasting sunflower inbred lines, R453 and B481–6 (early and delayed senescence respectively), with the aim of identifying metabolic pathways associated to leaf senescence.

Results

Gene expression profiles revealed a higher number of differentially expressed genes, as well as, higher expression levels in R453, providing evidence for early activation of the senescence program in this line. Metabolic pathways associated with sugars and nutrient recycling were differentially regulated between the lines. Additionally, we identified transcription factors acting as hubs in the co-expression networks; some previously reported as senescence-associated genes in model species but many are novel candidate genes.

Conclusions

Understanding the onset and the progress of the senescence process in crops and the identification of these new candidate genes will likely prove highly useful for different management strategies to mitigate the impact of senescence on crop yield. Functional characterization of candidate genes will help to develop molecular tools for biotechnological applications in breeding crop yield.
Eriodictyol can modulate cellular auxin gradients to efficiently promote in vitro cotton fibre development
Authors: Khan Anam Qadir , Li Zhonghua , Ahmed Muhammad Mahmood , Wang Pengcheng , Zhang Xianlong , Tu Lili
Published: October 2019

Background

Flavonoids have essential roles in flower pigmentation, fibre development and disease resistance in cotton. Previous studies show that accumulation of naringenin in developing cotton fibres significantly affects fibre growth. This study focused on determining the effects of the flavonoids naringenin, dihydrokaempferol, dihydroquerectin and eriodictyol on fibre development in an in vitro system.

Results

20 μM eriodictyol treatment produced a maximum fibre growth, in terms of fibre length and total fibre units. To gain insight into the associated transcriptional regulatory networks, RNA-seq analysis was performed on eriodictyol-treated elongated fibres, and computational analysis of differentially expressed genes revealed that carbohydrate metabolism and phytohormone signaling pathways were differentially modulated. Eriodictyol treatment also promoted the biosynthesis of quercetin and dihydroquerectin in ovules and elongating fibres through enhanced expression of genes encodingchalcone isomerase,chalcone synthaseandflavanone 3-hydroxylase. In addition, auxin biosynthesis and signaling pathway genes were differentially expressed in eriodictyol-driven in vitro fibre elongation. In absence of auxin, eriodictyol predominantly enhanced fibre growth when the localized auxin gradient was disrupted by the auxin transport inhibitor, triiodobenzoic acid.

Conclusion

Eriodictyol was found to significantly enhance fibre development through accumulating and maintaining the temporal auxin gradient in developing unicellular cotton fibres.
Diabetes and risk of peripheral artery disease in patients undergoing first-time coronary angiography between 2000 and 2012 – a nationwide study
Authors: Kamil Sadaf , Sehested Thomas S. G. , Carlson Nicholas , Houlind Kim , Lassen Jens F. , N. Bang Casper , Dominguez Helena , Pedersen Christian T. , Gislason Gunnar H.
Published: October 2019

Background

The risk of peripheral artery disease (PAD) in patients with diabetes mellitus (DM) and coronary artery disease (CAD) is an important and inadequately addressed issue. Our aim is to examine the impact of DM on risk of PAD in patients with different degrees of CAD characterized by coronary angiography (CAG).

Methods

Using nationwide registers we identified all patients aged ≥18 years, undergoing first time CAG between 2000 and 2012. Patients were categorized into DM/Non-DM group, and further classified into categories according to the degree of CAD i.e., no-vessel disease, single-vessel disease, double-vessel disease, triple-vessel disease, and diffuse disease. Risk of PAD was estimated by 5-year cumulative-incidence and adjusted multivariable Cox-regression models.

Results

We identified 116,491 patients undergoing first-time CAG. Among these, a total of 23.969 (20.58%) had DM. Cumulative-incidence of PAD among DM patients vs. non-DM were 8.8% vs. 4.9% for no-vessel disease, 8.2% vs. 4.8% for single-vessel disease, 10.2% vs. 6.0% for double-vessel disease, 13.0% vs. 8.4% for triple-vessel disease, and 6.8% vs. 6.1% for diffuse disease, respectively. For all patients with DM, the cox-regression analysis yielded significantly higher hazards of PAD compared with non-DM patients with HR 1.70 (no-vessel disease), 1.96 (single-vessel disease), 2.35 (double-vessel disease), 2.87 (triple-vessel disease), and 1.46 (diffuse disease), respectively (interaction-p 0.042).

Conclusion

DM appears to be associated with increased risk of PAD in patients with and without established CAD, with increasing risk in more extensive CAD. This observation indicates awareness on PAD risk in patients with DM, especially among patients with advanced CAD.
Building the skills and confidence of early childhood educators to work with parents: study protocol for the Partnering with Parents cluster randomised controlled trial
Authors: Petrovic Zvezdana , Clayton Olivia , Matthews Jan , Wade Catherine , Tan Lina , Meyer Denny , Gates Antony , Almendingen Alex , Cann Warren
Published: October 2019

Background

In the early years of life, the benefits of parental engagement in children’s learning are well documented. Early childhood educators are a potentially effective source of support, having opportunity to engage with parents on key issues related to children’s learning and development. Educators report a need for more practical strategies for building positive partnerships with the parents of children in their care. To address this need, we have developed a practice support system, Partnering with Parents, to guide educators in Early Childhood Education and Care (ECEC) through practical strategies for working with parents. Partnering with Parents is designed to be embedded in everyday service delivery.

Methods

Using a cluster randomised controlled trial (cRCT) with intervention and wait-list control groups, we aim to evaluate the effectiveness of the Partnering with Parents practice support system under normal service conditions. The intervention is being trialled in ECEC services across Victoria, Australia. Services in the intervention group implemented the 10-week intervention before the control group commenced the intervention. Educators and parents of children attending the participating services are taking part in evaluating the intervention by completing questionnaires online at three time points (before, immediately after, and 3 months after the intervention group received the intervention).

Results

One hundred eighteen educators and 302 parents recruited from 19 participating ECEC services have consented to take part in the trial.

Conclusions

There is considerable potential for ECEC services to improve everyday interactions with parents and potentially child outcomes, by implementing this practice support model. Future research in this field can examine long-term effects of improving the parent-educator relationship. The intervention has potential to be widely embedded in educator training or professional development.

Trial registration

Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12619000488101. Prospectively registered 25 March 2019.
Age-related deficits in bilateral motor synergies and force coordination
Authors: Kang Nyeonju , Roberts Lisa M. , Aziz Clara , Cauraugh James H.
Published: October 2019

Background

Ageing may cause impairments in executing bilateral movement control. This study investigated age-related changes in interlimb force coordination across multiple trials by quantifying bilateral motor synergies based on the uncontrolled manifold hypothesis. Participants completed the trials with and without visual feedback.

Methods

Twenty healthy individuals (10 older adults and 10 young adults) performed 12 isometric force control trials for the two vision conditions at 5% of maximal voluntary contraction. All dependent variables were analyzed in two-way mixed model (Group × Vision Condition; 2 × 2) ANOVAs with repeated measures on the last factor.

Results

The analyses revealed that older adults had greater mean force produced by two hands in both vision conditions (i.e., yes and no visual feedback). Across both vision conditions, the older adult group showed greater asymmetrical force variability (i.e., standard deviation of non-dominant hand > standard deviation of dominant hand) and revealed more positive correlation coefficients between forces produced by two hands as compared with the young adult group. Finally, an index of bilateral motor synergies was significantly greater in young adults than older adults when visual feedback was available.

Conclusion

The current findings indicate that deficits in interlimb force coordination across multiple trials appeared in older adults.
Transitioning of older Australian women into and through the long-term care system: a cohort study using linked data
Authors: Rahman Md. Mijanur , Efird Jimmy T. , Byles Julie E.
Published: October 2019

Background

Over two-thirds of older Australians use different types/levels of aged care at some point in later life. Our aims were to estimate transitional probabilities and to identify risk factors influencing the movement between different levels of long-term care.

Methods

The sample consisted of 9007 women from the 1921-26 birth cohort of the Australian Longitudinal Study on Women’s Health. Transitional probabilities between different levels of long-term care were estimated using a continuous-time Markov model.

Results

An 11-fold transition rates ratio was observed for the movement from non-user to home and community care (HACC) versus non-user to residential aged care (RAC). The predicted probabilities of remaining in the non-user state, HACC, and RAC after 10 years from the baseline were .28, .24, and .11, respectively. While the corresponding probabilities of dying from these states were .36, .65, and .90. The risk of transitioning from the non-user state to either HACC or RAC was greater for participants who were older at baseline, widowed, living outside of major cities, having difficulties in managing income, or having chronic condition, poor/fair self-rated health, or lower SF-36 scores (p < .05).

Conclusion

Women spend a substantial period of their later life using long-term care. Typically, this will be in the community setting with a low level of care. The transition to either HACC or RAC was associated with several demographic and health-related factors. Our findings are important for the planning and improvement of long-term care among future generations of older people.

Trial registration

Not applicable.