bluuebunny/crossref_metadata_2025 huggingface dataset:
Coupled Aerosol-Chemistry–Climate Twentieth-Century Transient Model Investigation: Trends in Short-Lived Species and Climate Responses
Authors: Koch Dorothy , Bauer Susanne E. , Del Genio Anthony , Faluvegi Greg , McConnell Joseph R. , Menon Surabi , Miller Ronald L. , Rind David , Ruedy Reto , Schmidt Gavin A. , Shindell Drew
Published: January 2011

The authors simulate transient twentieth-century climate in the Goddard Institute for Space Studies (GISS) GCM, with aerosol and ozone chemistry fully coupled to one another and to climate including a full dynamic ocean. Aerosols include sulfate, black carbon (BC), organic carbon, nitrate, sea salt, and dust. Direct and BC-snow-albedo radiative effects are included. Model BC and sulfur trends agree fairly well with records from Greenland and European ice cores and with sulfur deposition in North America; however, the model underestimates the sulfur decline at the end of the century in Greenland. Global BC effects peak early in the century (1940s); afterward the BC effects decrease at high latitudes of the Northern Hemisphere but continue to increase at lower latitudes. The largest increase in aerosol optical depth occurs in the middle of the century (1940s–80s) when sulfate forcing peaks and causes global dimming. After this, aerosols decrease in eastern North America and northern Eurasia leading to regional positive forcing changes and brightening. These surface forcing changes have the correct trend but are too weak. Over the century, the net aerosol direct effect is −0.41 W m−2, the BC-albedo effect is −0.02 W m−2, and the net ozone forcing is +0.24 W m−2. The model polar stratospheric ozone depletion develops, beginning in the 1970s. Concurrently, the sea salt load and negative radiative flux increase over the oceans around Antarctica. Net warming over the century is modeled fairly well; however, the model fails to capture the dynamics of the observed midcentury cooling followed by the late century warming. Over the century, 20% of Arctic warming and snow–ice cover loss is attributed to the BC-albedo effect. However, the decrease in this effect at the end of the century contributes to Arctic cooling.

To test the climate responses to sulfate and BC pollution, two experiments were branched from 1970 that removed all pollution sulfate or BC. Averaged over 1970–2000, the respective radiative forcings relative to the full experiment were +0.3 and −0.3 W m−2; the average surface air temperature changes were +0.2° and −0.03°C. The small impact of BC reduction on surface temperature resulted from reduced stability and loss of low-level clouds.
Assessing Simulated Clouds and Radiative Fluxes Using Properties of Clouds Whose Tops are Exposed to Space
Authors: Cole Jason , Barker Howard W. , Loeb Norman G. , von Salzen Knut
Published: January 2011

Coincident top-of-atmosphere (TOA) radiative fluxes and cloud optical properties for portions of clouds whose tops are exposed to space within several pressure ranges are used to evaluate how a GCM realizes its all-sky radiative fluxes and vertical structure. In particular, observations of cloud properties and radiative fluxes from the Clouds and the Earth’s Radiant Energy System (CERES) Science Team are used to assess the Canadian Centre for Climate Modeling and Analysis atmospheric global climate model (CanAM4). Through comparison of CanAM4 with CERES observations it was found that, while the July-mean all-sky TOA shortwave and longwave fluxes simulated by CanAM4 agree well with those observed, this agreement rests on compensating biases in simulated cloud properties and radiative fluxes for low, middle, and high clouds. Namely, low and middle cloud albedos simulated by CanAM4 are larger than those observed by CERES attributable to CanAM4 simulating cloud optical depths via large liquid water paths that are too large but are partly compensated by too small cloud fractions. It was also found that CanAM4 produces 2D histograms of cloud fraction and cloud albedo for low, middle, and high clouds that are significantly different than generated using the CERES observations.
Impact of Spring Soil Moisture on Surface Energy Balance and Summer Monsoon Circulation over East Asia and Precipitation in East China
Authors: Zhang Renhe , Zuo Zhiyan
Published: January 2011

Numerous studies have been conducted on the impact of soil moisture on the climate, but few studies have attempted to diagnose the linkage between soil moisture and climate variability using observational data. Here, using both observed and reanalysis data, the spring (April–May) soil moisture is found to have a significant impact on the summer (June–August) monsoon circulation over East Asia and precipitation in east China by changing surface thermal conditions. In particular, the spring soil moisture over a vast region from the lower and middle reaches of the Yangtze River valley to north China (the YRNC region) is significantly correlated to the summer precipitation in east China. When the YRNC region has a wetter soil in spring, northeast China and the lower and middle reaches of the Yangtze River valley would have abnormally higher precipitation in summer, while the region south of the Yangtze River valley would have abnormally lower precipitation. An analysis of the physical processes linking the spring soil moisture to the summer precipitation indicates that the soil moisture anomaly across the YRNC region has a major impact on the surface energy balance. Abnormally wet soil would increase surface evaporation and hence decrease surface air temperature (Ta). The reduced Ta in late spring would narrow the land–sea temperature difference, resulting in the weakened East Asian monsoon in an abnormally strengthened western Pacific subtropical high that is also located farther south than its normal position. This would then enhance precipitation in the Yangtze River valley. Conversely, the abnormally weakened East Asian summer monsoon allows the western Pacific subtropical high to wander to south of the Yangtze River Valley, resulting in an abnormally reduced precipitation in the southern part of the country in east China.
Satellite and Numerical Model Investigation of Two Heavy Rain Events over the Central Mediterranean
Authors: Laviola Sante , Moscatello Agata , Miglietta Mario Marcello , Cattani Elsa , Levizzani Vincenzo
Published: January 2011

Two heavy rain events over the Central Mediterranean basin, which are markedly different by genesis, dimensions, duration, and intensity, are analyzed. Given the relative low frequency of this type of severe storms in the area, a synoptic analysis describing their development is included. A multispectral analysis based on geostationary multifrequency satellite images is applied to identify cloud type, hydrometeor phase, and cloud vertical extension. Precipitation intensity is retrieved from (i) surface rain gauges, (ii) satellite data, and (iii) numerical model simulations. The satellite precipitation retrieval algorithm 183-Water vapor Strong Lines (183-WSL) is used to retrieve rain rates and cloud hydrometeor type, classify stratiform and convective rainfall, and identify liquid water clouds and snow cover from the Advanced Microwave Sounding Unit-B (AMSU-B) sensor data. Rainfall intensity is also simulated with the Weather Research and Forecasting (WRF) numerical model over two nested domains with horizontal resolutions of 16 km (comparable to that of the satellite sensor AMSU-B) and 4 km. The statistical analysis of the comparison between satellite retrievals and model simulations demonstrates the skills of both methods for the identification of the main characteristics of the cloud systems with a suggested overall bias of the model toward very low rain intensities. WRF (in the version used for the experiment) seems to classify as low rain intensity regions those areas where the 183-WSL retrieves no precipitation while sensing a mixture of freshly nucleated cloud droplets and a large amount of water vapor; in these areas, especially adjacent to the rain clouds, large amounts of cloud liquid water are detected. The satellite method performs reasonably well in reproducing the wide range of gauge-detected precipitation intensities. A comparison of the 183-WSL retrievals with gauge measurements demonstrates the skills of the algorithm in discriminating between convective and stratiform precipitation using the scattering and absorption of radiation by the hydrometeors.
Current and Density Observations of Packets of Nonlinear Internal Waves on the Outer New Jersey Shelf
Authors: Teague W. J. , Wijesekera H. W. , Avera W. E. , Hallock Z. R.
Published: January 2011

Closely spaced observations of nonlinear internal waves (NLIWs) were made on the outer continental shelf off New Jersey in June 2009. Nearly full water column measurements of current velocity were made with four acoustic Doppler current profilers (ADCPs) that were moored about 5 km apart on the bottom along a line approximately normal to the bathymetry between water depths of 67 and 92 m. Density profiles were obtained from two vertical strings of temperature and conductivity sensors that were deployed near each of the interior ADCP moorings. In addition, a towed ScanFish provided profiles and fixed-level records of temperature and salinity through several NLIW packets near the moorings. Several case studies were selected to describe the propagation of the NLIWs. One to three solitary waves of depression were observed in five selected packets. There were also occurrences of multiple-phase dispersive wave packets. The average propagation speed corrected for advection of the observed waves was 0.51 ± 0.09 m s−1. The waves were directed primarily shoreward (~northwestward) along the mooring line with average wavelengths and periods of about 300 m and 10 min, respectively. Wave amplitudes and energies decreased with decreasing water depth. The observed wave parameters can be locally described by a two-layer Korteweg–de Vries (KdV) model, except for the decreasing amplitudes, which may be due to shear-induced dissipation and/or bottom drag. The various complementary observations utilized in this study present a unique description of NLIWs.
Fabric wrinkle characterization and classification using modified wavelet coefficients and support-vector-machine classifiers
Authors: Jingjing Sun  , Ming Yao  , Bugao Xu  , Bel Patricia
Published: January 2011

In this paper we present a novel wrinkle evaluation method that uses modified wavelet coefficients and optimized support-vector-machine (SVM) classifications to characterize and classify the wrinkling appearance of fabric. Fabric images were decomposed with the wavelet transform, and five parameters were defined, based on the modified wavelet coefficients, to describe wrinkling features, such as orientation, hardness, density, and contrast. These parameters were also used as the inputs of optimized SVM classifiers to obtain overall wrinkle grading in accordance with the standard American Association of Textile Chemists and Colorists smoothness appearance (SA) replicas. The SVM classifiers, based on a linear kernel and a radial-basis-function kernel, were used in the study. The effectiveness of this evaluation method was tested by 300 images of five selected fabrics that had different fiber contents, weave structures, colors, and laundering cycles. The cross-validation tests on the SA classifications indicated that the SA grades of more than 75% of these diversified samples could be recognized correctly. The extracted wrinkle parameters provided useful information for textile, appliance, and detergent manufactures to inspect wrinkling behaviors of fabrics.
Investigations of puncture behaviors of woven fabrics from finite element analyses and experimental tests
Authors: Sun Baozhong , Wang Yonxin , Wang Ping , Hu Hong , Gu Bohong
Published: January 2011

This paper reports the puncture behaviors of woven fabrics from experimental and finite element analyses (FEAs) approaches. In the experimental approach, the puncture behaviors of three kinds of woven fabrics, plain woven, 2/2 twill woven, and 2/1 twill, were tested under quasi-static conditions and the puncture load-displacement curves of the fabrics were obtained. The puncture damage morphologies were also observed. In FEA simulation, the puncture damage evolutions were calculated at the microstructure level and compared with those in experimental approach. Good agreements between the experimental and FEA approaches were found. From the FEA results, it was found that the puncture damage includes three stages: fabric tension, weft and warp yarn slippage, and yarn breakage and pullout. It was also found that there are almost no differences when the puncture acts at the interweaving point or between interweaving point for the three kinds of woven fabric. It is expected that such an investigation could provide guidance to the design of technical woven fabrics, such as geotextiles, tufted carpet the background layer, and flexible pipeline tubes, which often suffer from the puncture damages.
‘Not an act of God’: anger and citizenship in press coverage of British man-made disasters
Authors: Pantti Mervi Katriina , Wahl-Jorgensen Karin
Published: January 2011

Anger motivates people to engage in political action, fuelling collective struggles for justice and recognition. However, because of its close association with irrationality and aggression, the public expression of anger has historically been discouraged. This article focuses on expressions of anger in British disaster coverage between 1952 and 1999. In particular, we look at the relationship between anger, journalistic practices and opportunities for ordinary people to express themselves politically. Our article concludes that anger opens up a space for ordinary people to critique power holders, allowing victims and those affected by disasters to raise questions of systemic failure and blame. And such questions, it appears, are increasingly part of the emotional management style of disaster journalism.
The Violent South: Culture of Honor, Social Disorganization, and Murder in Appalachia
Authors: Andreescu Viviana , Shutt John Eagle , Vito Gennaro F.
Published: January 2011

Nisbett and Cohen contended that consistently higher argument-related homicide rates in the South are a result of early historical and economic circumstances of the frontier that contributed to the development of a persistent ‘‘culture of honor,’’ which legitimized violence in response to provocations. Using 1990—1992 argument-related homicide data for Appalachian counties and considering the effect of the religious culture, this study attempts to reexamine Cohen’s finding that social stability increased honor/argument-related homicide rates in the American South but had the opposite effect in the North. Although results show that interregional differences in homicide rate exist in Appalachia and could be explained by an existing ‘‘culture of honor’’ reinforced by certain religious beliefs, this analysis did not find support for Cohen’s hypotheses. Family stability appears to be a crime deterrent in both subregions, though the relationship is not significant. Community stability is positively related to homicide rates in both subregions, but the effect is significant in the North and not in the South, as Cohen predicted. In addition, when controlling for relevant structural covariates, the authors found that counties where most adherents belonged to a conservative Protestant denomination had on average significantly higher argument-related homicide rates, whereas counties with most Roman Catholic adherents had significantly lower murder rates.
Explaining the IPV Arrest Decision: Incident, Agency, and Community Factors
Authors: Dichter Melissa E. , Marcus Steven C. , Morabito Melissa S. , Rhodes Karin V.
Published: January 2011

Over the last half century in the United States, we have seen the criminal system become increasingly aggressive in its response to violence against intimate partners. Although policies have been implemented to encourage arrest, police continue to maintain discretion over whether or whom to arrest in cases of intimate partner violence (IPV). Using data from three national data sets, we examined the contributions of incident, agency, and community factors on the police arrest decisions, independently considering atypical cases of women arrested and dual arrest. The findings from this study reveal that incident factors account for the majority of the variance in arrest for single arrest cases, more so than factors associated with the particular police agency or the community in which the alleged crime occurred. The frequency of dual arrest is affected more by community factors. The findings from this study can be used to guide police training and local policies as well as to inform legislation designed to prevent variance in arrest based on sociodemographic and other extralegal factors.
Magnetic Resonance Spectroscopy in the Diagnostic Evaluation of Brainstem Lesions in Alexander Disease
Authors: Davison James E. , Davies Nigel P. , English Martin W. , Philip Sunny , MacPherson Lesley K. R. , Gissen Paul , Peet Andrew C.
Published: January 2011

Alexander disease is a progressive neurodegenerative disease, which can present with brainstem lesions with imaging characteristics similar to multifocal low-grade glioma, thus presenting a diagnostic dilemma. The authors report a 6-year-old child presenting with multifocal brainstem lesions subsequently diagnosed to have Alexander disease. In vivo magnetic resonance spectroscopy generated a metabolite profile of the lesion allowing differentiation from low-grade glioma. Magnetic resonance spectroscopy is a powerful tool in the assessment of brainstem lesions and is a useful adjunct to conventional magnetic resonance imaging in the assessment and diagnosis of atypical brain lesions.
Predictors of Outcome in Term Infants With Neonatal Seizures Subsequent to Intrapartum Asphyxia
Authors: Garfinkle Jarred , Shevell Michael I.
Published: January 2011

The objective of this study was to define potential clinical prognostic factors for term infants with neonatal seizures subsequent to intrapartum asphyxia. The authors completed a retrospective analysis of 62 term infants with clinical neonatal seizures subsequent to intrapartum asphyxia. Logistic regression analysis was applied to determine the independent prognostic indicators of an adverse outcome. A total of 23 (37%) infants had a normal outcome, 34 (55%) survived with 1 or more neurodevelopmental impairments (23 cerebral palsy, 28 global developmental delay, 15 epilepsy, with 18 combination of two, and 9 all three), and 5 (8%) died. Six variables were associated with an adverse outcome, but only the presence of meconium aspiration, a low (≤ 3) 1-minute Apgar score, seizure type other than focal clonic, and moderately severely abnormal electroencephalography (EEG) background findings were independently associated with an adverse outcome. Signs of acute distress are predictors of adverse outcome, alongside seizure semiology and moderate to severe EEG background abnormalities.
Idiopathic Hypersomnia: A Report of Three Adolescent-Onset Cases in a Two-Generation Family
Authors: Janáčková Soňa , Motte Jacques , Bakchine Serge , Sforza Emilia
Published: January 2011

Idiopathic hypersomnia is an uncommon sleep disorder characterized by prolonged sleep time and excessive daytime sleepiness without cataplexy. This study concerned a case of familial occurrence. The proband expressed an idiopathic hypersomnia with long sleep time at the age of 12 years. Clinical interview and ad libitum polysomnographic study did not reveal any symptoms of narcolepsy or other sleep disorders. Family history revealed that a 20-year-old sister had experienced symptoms of hypersomnia from the age of 16 and their mother had been diagnosed with idiopathic hypersomnia previously. The diagnosis of idiopathic hypersomnia with long sleep time was confirmed in the sister by clinical interview and ad libitum polysomnography. Human leukocyte antigen (HLA) did not reveal the DQB1-0602 phenotype in the proband and relatives. This report confirms the hypothesis of a genetic predisposition in idiopathic hypersomnia.
Functional Outcomes of Multilevel Botulinum Toxin and Comprehensive Rehabilitation in Cerebral Palsy
Authors: Balbaloglu Ozlem , Basaran Aynur , Ayoglu Hilal
Published: January 2011

The objective of this study was to measure the effect of lower extremity multilevel botulinum toxin A injections and comprehensive rehabilitation on spasticity and to determine the functional gains in ambulatory children with cerebral palsy. Sixteen ambulatory children with spastic cerebral palsy (9 hemiplegic, 7 diplegic), aged between 3 and 8 years, who were able to walk with or without assistance (Gross Motor Functional Classification System I-III) were recruited to the study. Botulinum toxin A injections were applied to a total of 23 extremities, followed by a comprehensive rehabilitation program. Walking distance and walking speed (evaluated by the Six-Minute Walk Test) were significantly improved after treatment. Similarly, scores on the Observational Gait Scale (assessed by video gait analysis) increased significantly. Improvements in muscle length, spasticity, and selectivity were recorded. Reduced muscle spasticity after botulinum toxin A injections in children with cerebral palsy, with a comprehensive rehabilitation program, enabled clinically relevant improvements in functional ability.
Us Versus Them
Authors: Cikara Mina , Botvinick Matthew M. , Fiske Susan T.
Published: January 2011

Intergroup competition makes social identity salient, which in turn affects how people respond to competitors’ hardships. The failures of an in-group member are painful, whereas those of a rival out-group member may give pleasure—a feeling that may motivate harming rivals. The present study examined whether valuation-related neural responses to rival groups’ failures correlate with likelihood of harming individuals associated with those rivals. Avid fans of the Red Sox and Yankees teams viewed baseball plays while undergoing functional magnetic resonance imaging. Subjectively negative outcomes (failure of the favored team or success of the rival team) activated anterior cingulate cortex and insula, whereas positive outcomes (success of the favored team or failure of the rival team, even against a third team) activated ventral striatum. The ventral striatum effect, associated with subjective pleasure, also correlated with self-reported likelihood of aggressing against a fan of the rival team (controlling for general aggression). Outcomes of social group competition can directly affect primary reward-processing neural systems, which has implications for intergroup harm.
I 5683 You
Authors: Topolinski Sascha
Published: January 2011

When people perform actions, effects associated with the actions are activated mentally, even if those effects are not apparent. This study tested whether sequences of simulations of virtual action effects can be integrated into a meaning of their own. Cell phones were used to test this hypothesis because pressing a key on a phone is habitually associated with both digits (dialing numbers) and letters (typing text messages). In Experiment 1, dialing digit sequences induced the meaning of words that share the same key sequence (e.g., 5683, LOVE). This occurred even though the letters were not labeled on the keypad, and participants were not aware of the digit-letter correspondences. In Experiment 2, subjects preferred dialing numbers implying positive words (e.g., 37326, DREAM) over dialing numbers implying negative words (e.g., 75463, SLIME). In Experiment 3, subjects preferred companies with phone numbers implying a company-related word (e.g., LOVE for a dating agency, CORPSE for a mortician) compared with companies with phone numbers implying a company-unrelated word.
Immigrant general practitioners in Norway: A special resource? A qualitative study
Authors: Díaz Esperanza , Hjörleifsson Stefán
Published: January 2011

Aims: To explore whether and how immigrant general practitioners (GPs) in two major cities in Norway think that their own ethnic background affects their practices and their work. Methods: Qualitative focus group and individual interviews with seven immigrant GPs, five men and two women, age 36—65 years. Their clinical experience in Norwegian primary health care ranged from four to 30 years. Analysis was conducted by systematic text condensation. Results: First, immigrant GPs described a gradual process of becoming bicultural: the GPs communicate with immigrant patients on their own terms and draw upon their special knowledge from abroad to help selected patients, while also adapting to Norwegian cultural expectations of the GP’s role. Second, the GPs described being aware of cultural issues in consultations with immigrant and Norwegian patients, but rarely making these issues explicit. The GPs ventured that cultural awareness, together with their personal experience in their own countries and as immigrants in Norway, made them able to sometimes help immigrant patients better than Norwegian GPs. Third, immigrant GPs experienced a big workload related to immigrant patients, but they accepted this as a natural part of their work. Fourth, immigrant GPs felt that they had to work harder and be more careful than their Norwegian colleagues in order to avoid complaints from patients, and to be accepted by colleagues. Conclusions: Immigrant GPs express broad cultural competence and keen cultural awareness in their consultations. The immigrant background of these GPs could be considered as a special resource for clinical practice.
Conditions of a successful status graduation ceremony: Formerly incarcerated urban youth and their tenuous grip on success
Authors: Fader Jamie J
Published: January 2011

This article offers an ethnographic examination of a graduation ceremony from ‘Santana School’, a reform school targeting youthful drug offenders. After returning to the facility with five former residents, I contend that ceremony was a rare opportunity for these young men to reclaim the carceral experience on their own terms. Wearing their own clothing, using their own language, and playing their own music, they affirmed both their personal choices and the legitimacy of their cultural identities as Black men and its compatibility with success. Returning to the place where they had been held against their will offered them the chance to actively shape the staff’s collective memories of them and who they could become, as well as transforming their own narratives of the place and their time there. However, unlike most status passages, Santana’s graduation ceremony failed to confer the concrete privileges of a truly new status. I analyze the meaning of the experience for the young men in my study in light of Maruna’s call in this issue for the provision of redemption rituals which could strip the stigma from incarceration and restore the offender’s status in the community.
Reentry as a rite of passage
Authors: Maruna Shadd
Published: January 2011

Mary Douglas argues that, ‘There are some things we cannot experience without ritual.’ Ex-prisoner reintegration may be one of them. The punishment process involves an inordinate amount of ritual behavior, from the drama of the courtroom to the elaborate de-individuation processes involved in institutionalization. Durkheim argues that these rituals serve a distinct purpose for society: engendering social solidarity and shaping penal sensibilities. Like the commission of a crime, the reintegration of the former outcast back into society represents a challenge to the moral order, a delicate transition fraught with danger and possibility. However, unlike punishment, reintegration is not a process characterized by well-orchestrated and familiar rituals. This lack might explain the failings of prisoner reentry in contemporary society. This article reviews the sociological and anthropological literature on rituals, explaining what they are and what they do, focusing in particular on the role of status degradation ceremonies in criminal justice work. Drawing on this literature, the core elements that would be needed to develop rituals of reintegration powerful enough to counteract these degradation effects are discussed, and the potential impact of such hypothetical rituals is explored.
Reduced Order Models Using Generalized Eigenanalysis
Authors: Ripepi M , Masarati P
Published: January 2011

This article discusses the use of generalized eigenanalysis to extract reduced order models from the linearization of structural and aeroelastic problems written in differential-algebraic form. These problems may arise from multi-body analysis and in general from mixed approaches, where a high degree of generality and modelling flexibility are sought. A method based on a shift technique is proposed, that allows to exploit the regularity of the matrix pencil resulting from the linearization of differential-algebraic problems. Alternatively, the generalized Schur decomposition, or QZ decomposition, is directly used to select a cluster of eigenvalues related to the dynamic states. The two approaches are used to reduce the model to ordinary differential in state-space form. The two methods are applied to simple numerical problems, highlighting their robustness and versatility compared to other techniques. They are also applied to numerical models of a high-altitude long endurance aircraft obtained using a free general-purpose multi-body solver and a dedicated mixed variational solver.
The role of the renin—angiotensin system in the pathogenesis of intracranial aneurysms
Authors: Shoja Mohammadali M , Agutter Paul S , Tubbs R Shane , Payner Troy D , Ghabili Kamyar , Cohen-Gadol Aaron A
Published: January 2011

Introduction: Recent work has begun to elucidate the pathogenesis of intracranial aneurysms (IA) and has shown that many genes are involved in the risk for this condition. There has also been increasing research interest in the renin—angiotensin system (RAS) in the brain and its involvement in a range of cardiovascular and neurological disorders. The possibility that the RAS is implicated in the pathogenesis of IA merits further investigation. The aim of this article is to review the literature on the pathogenesis of IA and the pathophysiological significance of the brain RAS, and to identify directions for research into their association.

Methods and results : A survey of the literature in these fields shows that although factors contributing to systemic hypertension predispose to IA, a large number of genes involved in endothelial cell adhesion, smooth muscle activity, extracellular matrix dynamics and the inflammatory and immune responses are also implicated. The brain RAS has a significant role in regulating blood pressure and in maintaining cerebrovascular autoregulation, but angiotensin II receptors are also involved in the maintenance of endothelial cell and vascular smooth muscle function and in the inflammatory response in the brain.

Conclusions: There is strong, albeit largely circumstantial, evidence in the literature for a relationship between the brain RAS and the formation of IA. Research on the association between polymorphisms in RAS-related genes and the incidence of unruptured and ruptured IA is indicated.
Development and Validation of the Student Internalizing Behavior Screener: Examination of Reliability, Validity, and Classification Accuracy
Authors: Cook Clayton R. , Rasetshwane Kutlo B. , Truelson Erica , Grant Stephanie , Dart Evan H. , Collins Tai A. , Sprague Jeffrey
Published: January 2011

Students with internalizing behavior patterns are often overlooked and underserved in schools, which is problematic in that they are at risk for a host of negative outcomes. As a result, there is a need for universal screening procedures to proactively detect students with these behavior patterns and to provide them with early, ongoing supports. The purpose of this study was to examine the reliability, validity, and classification accuracy of the Student Internalizing Behavior Screener using a sample of elementary-age students. The results indicated that the screener demonstrated adequate evidence of reliability and validity. Results also revealed an optimal cutoff score to maximize accurate hits and minimize diagnostic errors, and they demonstrated that the screener was able to identify a unique group of behaviorally and emotionally at-risk students. The implications of the results are discussed, as well as the directions for future research on screening practices for students with internalizing behavior patterns.
Work, Power and Performance: Analysing the ‘Reality’ Game ofThe Apprentice
Authors: Couldry Nick , Littler Jo
Published: January 2011

This article addresses the relationship between the British version of the reality television programme The Apprentice and the shifting working cultures of contemporary neoliberalism. It explores how the programme enacts, through ritualized play, many skills required by the ‘flexible’ work economy: emotional commitment, entrepreneurial adaptability, a combination of team conformity and personal ambition. In particular, it highlights how newly calibrated requirements of sociality, ‘passion’, and power-as-charisma are negotiated by the programme in relation to broader emergent norms of neoliberal governmentality. However, the article simultaneously argues against overly deterministic deployments of governmentality theory, suggesting it be both supplemented by other tools (media rituals and the affective role of passion), and reoriented back towards a Foucauldian emphasis upon the instability of power. This can, it argues, both enable the programme’s appeal to be more effectively understood and help us comprehend the spaces and places where neoliberal governmentality fails, wholly or partly, to be foregrounded.
Neurocysticercosis
Authors: Singhi Pratibha
Published: January 2011

Neurocysticercosis (NCC) is the most common cause of acquired epilepsy in developing countries. It can present variably depending on the location and stage of cysts in the nervous system, and the host immune response. The most common presentation of parenchymal NCC is with seizures that are usually focal and brief; status epilepticus occurs in some cases. About a third of cases have headache and vomiting. Diagnosis is made by either CT or MRI. Single, small, contrast enhancing lesions are the most common; visualization of a scolex is diagnostic. Some cases have multiple cysts with a characteristic starry-sky appearance. Although treatment with cysticidal therapy continues to be debated, there is increasing evidence that it helps through increased and faster resolution of CT lesions; whether there is any improvement in long-term seizure control needs further study. It should not be used in cysticercus encephalitis or in ophthalmic NCC and used with caution in extraparenchymal NCC. It is of no use in calcified lesions. Corticosteroids are used simultaneously to reduce cerebral oedema. Seizures respond well to a single antiepileptic, and the seizure recurrence rate is low in cases with single lesions; those with multiple, persistent or calcified lesions usually have recurrent seizures. Extraparenchymal NCC is often associated with intracranial hypertension, hydrocephalous and chronic meningitis; it has a guarded prognosis; surgical intervention is required in many cases. Management of NCC needs to be individualized. NCC is potentially eradicable; proper sanitation, hygiene and animal husbandry are warranted.
Weighty Matters
Authors: Schneider Iris K. , Rutjens Bastiaan T. , Jostmann Nils B. , Lakens Daniël
Published: January 2011

Previous work showed that concrete experiences of weight influence people’s judgments of how important certain issues are. In line with an embodied simulation account but contrary to a metaphor-enriched perspective, this work shows that perceived importance of an object influences perceptions of weight. Two studies manipulated information about a book’s importance, after which, participants estimated its weight. Importance information caused participants to perceive the book to be heavier. This was not merely a semantic association, because weight perceptions were affected only when participants physically held the book. Furthermore, importance information influenced weight perceptions but not perceptions of monetary value. These findings extend previous research by showing that the activation direction from weight to importance can be reversed, thus suggesting that the connection between importance and weight goes beyond metaphorical mappings. Implications for the debate on interpretation of findings on the interplay between bodily states and abstract information are discussed.
On Being Angry and Punitive
Authors: Ask Karl , Pina Afroditi
Published: January 2011

Previous research has demonstrated that anger increases the tendency to blame and punish others for harmful behaviors. This study investigated whether such attributions extend to judgments of criminal intent, and it examined the mechanisms by which anger influences punitiveness. In an experiment, angry, sad, and neutral participants read about an ambiguously criminal behavior. As hypothesized, angry participants judged the behavior as being more intentional and the perpetrator as having more causal control than did neutral participants, and they were more willing to punish the wrongdoer. Sadness did not have a demonstrable effect on judgments, indicating a specific role of anger rather than a general negative affect. Moreover, the effect of anger on punitiveness was mediated by perceived criminal intent but not by perceived causal control. Implications for legal judgments and theories of blame attribution are discussed.
Global gene expression analysis of human erythroid progenitors
Authors: Merryweather-Clarke Alison T. , Atzberger Ann , Soneji Shamit , Gray Nicki , Clark Kevin , Waugh Craig , McGowan Simon J. , Taylor Stephen , Nandi Asoke K. , Wood William G. , Roberts David J. , Higgs Douglas R. , Buckle Veronica J. , Robson Kathryn J. H.
Published: January 2011

Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here, we isolated 4 distinct populations at successive erythropoietin-dependent stages of erythropoiesis, including the terminal, pyknotic stage. The transcriptome was determined using Affymetrix arrays. First, we demonstrated the importance of using defined cell populations to identify lineage and temporally specific patterns of gene expression. Cells sorted by surface expression profile not only express significantly fewer genes than unsorted cells but also demonstrate significantly greater differences in the expression levels of particular genes between stages than unsorted cells. Second, using standard software, we identified more than 1000 transcripts not previously observed to be differentially expressed during erythroid maturation, 13 of which are highly significantly terminally regulated, including RFXAP and SMARCA4. Third, using matched filtering, we identified 12 transcripts not previously reported to be continuously up-regulated in maturing human primary erythroblasts. Finally, using transcription factor binding site analysis, we identified potential transcription factors that may regulate gene expression during terminal erythropoiesis. Our stringent lists of differentially regulated and continuously expressed transcripts containing many genes with undiscovered functions in erythroblasts are a resource for future functional studies of erythropoiesis. Our Human Erythroid Maturation database is available at https://cellline.molbiol.ox.ac.uk/eryth/index.html.
Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the International Peripheral T-cell Lymphoma Project
Authors: Weisenburger Dennis D. , Savage Kerry J. , Harris Nancy Lee , Gascoyne Randy D. , Jaffe Elaine S. , MacLennan Kenneth A. , Rüdiger Thomas , Pileri Stefano , Nakamura Shigeo , Nathwani Bharat , Campo Elias , Berger Francoise , Coiffier Bertrand , Kim Won-Seog , Holte Harald , Federico Massimo , Au Wing Y. , Tobinai Kensei , Armitage James O. , Vose Julie M. ,   for the International Peripheral T-cell Lymphoma Project
Published: January 2011

The International Peripheral T-cell Lymphoma Project is a collaborative effort to better understand peripheral T-cell lymphoma (PTCL). A total of 22 institutions submitted clinical and pathologic material on 1314 cases. One objective was to analyze the clinical and pathologic features of 340 cases of PTCL, not otherwise specified. The median age of the patients was 60 years, and the majority (69%) presented with advanced stage disease. Most patients (87%) presented with nodal disease, but extranodal disease was present in 62%. The 5-year overall survival was 32%, and the 5-year failure-free survival was only 20%. The majority of patients (80%) were treated with combination chemotherapy that included an anthracycline, but there was no survival advantage. The International Prognostic Index (IPI) was predictive of both overall survival and failure-free survival (P < .001). Multivariate analysis of clinical and pathologic prognostic factors, respectively, when controlling for the IPI, identified bulky disease (≥ 10 cm), thrombocytopenia (< 150 × 109/L), and a high number of transformed tumor cells (> 70%) as adverse predictors of survival, but only the latter was significant in final analysis. Thus, the IPI and a single pathologic feature could be used to stratify patients with PTCL-not otherwise specified for novel and risk-adapted therapies.
Three hydrophobic amino acids in Escherichia coli HscB make the greatest contribution to the stability of the HscB-IscU complex
Authors: Füzéry Anna K , Oh Jenny J , Ta Dennis T , Vickery Larry E , Markley John L
Published: January 2011

Background

General iron-sulfur cluster biosynthesis proceeds through assembly of a transient cluster on IscU followed by its transfer to a recipient apo-protein. The efficiency of the second step is increased by the presence of HscA and HscB, but the reason behind this is poorly understood. To shed light on the function of HscB, we began a study on the nature of its interaction with IscU. Our work suggested that the binding site of IscU is in the C-terminal domain of HscB, and two different triple alanine substitutions ([L92A, M93A, F153A] and [E97A, E100A, E104A]) involving predicted binding site residues had detrimental effects on this interaction. However, the individual contribution of each substitution to the observed effect remains to be determined as well as the possible involvement of other residues in the proposed binding site.

Results

In the work reported here, we used isothermal titration calorimetry to characterize the affinity of single alanine HscB mutants for IscU, and subsequently confirmed our results with nuclear magnetic resonance spectroscopy. Alanine substitutions of L92, L96, and F153 severely impaired the ability of HscB to form a complex with IscU; substitutions of R87, R99, and E100 had more modest effects; and substitutions of T89, M93, E97, D103, E104, R152, K156, and S160 had only minor or no detectable effects.

Conclusions

Our results show that the residues of HscB most important for strong interaction with IscU include three hydrophobic residues (L92, L96, and F153); in addition, we identified a number of other residues whose side chains contribute to a lesser extent to the interaction. Our results suggest that the triple alanine substitution at HscB positions 92, 96, and 153 will destabilize the HscB-IscU complex by ΔΔGb≅ 5.7 kcal/mol, equivalent to a ≅ 15000-fold reduction in the affinity of HscB for IscU. We propose that this triple mutant could provide a more definitive test of the functional importance of the HscB-IscU interaction in vivo than those used previously that yielded inconclusive results.
Induction of B-cell lymphoma by UVB Radiation in p53 Haploinsufficient Mice
Authors: Puebla-Osorio Nahum , Miyahara Yasuko , Coimbatore Sreevidya , Limón-Flores Alberto Y , Kazimi Nasser , Ullrich Stephen E , Zhu Chengming
Published: January 2011

Background

The incidence of non-Hodgkin's lymphoma has increased over recent years. The exact etiology of lymphoma remains unknown. Ultraviolet light exposure has been associated with the development of internal lymphoid malignancies and some reports suggest that it may play a role in the development of lymphoma in humans. Here we describe the characterization and progression of lymphoma in p53 heterozygous mice exposed to UVB irradiation.

Methods

UVB-irradiated p53+/-mice developed enlargement of the spleen. Isolated spleen cells were transplanted into Rag deficient hosts. The UV-induced tumor cells were analyzed by flow cytometry. The tumor cells were tagged with GFP to study their metastatic potential. SKY and karyotypic analysis were carried out for the detection of chromosomal abnormalities. Functional assays included in vitro class switch recombination assay, immunoglobulin rearrangement assay, as well as cytokine profiling.

Results

UVB-exposed mice showed enlargement of the spleen and lymph nodes. Cells transplanted into Rag deficient mice developed aggressive tumors that infiltrated the lymph nodes, the spleen and the bone marrow. The tumor cells did not grow in immune competent syngeneic C57Bl/6 mice yet showed a modest growth in UV-irradiated B6 mice. Phenotypic analysis of these tumor cells revealed these cells are positive for B cell markers CD19+, CD5+, B220+, IgM+and negative for T cell, NK or dendritic cell markers. The UV-induced tumor cells underwent robust in vitro immunoglobulin class switch recombination in response to lipopolysaccharide. Cytogenetic analysis revealed a t(14;19) translocation and trisomy of chromosome 6. These tumor cells secret IL-10, which can promote tumor growth and cause systemic immunosuppression.

Conclusion

UV-irradiated p53+/-mice developed lymphoid tumors that corresponded to a mature B cell lymphoma. Our results suggest that an indirect mechanism is involved in the development of internal tumors after chronic exposure to UV light. The induction of B cell lymphoma in UV-irradiated p53 heterozygous mice may provide a useful model for lymphoma development in humans.