bluuebunny/crossref_metadata_2025 huggingface dataset:
A systematic review and meta-analysis of neuroticism and anxiety during the COVID-19 pandemic
Authors: Zuunnast Khishigsuren , Regzedmaa Enkhtuvshin , Ganbat Mandukhai , Sambuunyam Munkhzul , Tsogoo Solongo , Radnaa Otgonbayar , Lkhagvasuren Nasantsengel
Published: January 2024

Introduction

In response to the global impact of the COVID-19 pandemic, concerns about mental health, particularly anxiety levels, have become prominent. This study aims to explore the relationship between neuroticism, a personality trait associated with emotional instability, and anxiety during the COVID-19 outbreak.

Methods

A comprehensive literature search was conducted using the Cochrane Library, HINARI, Google Scholar, and PUBMED, resulting in the identification of 26 relevant papers. The study protocol has been registered with PROSPERO under the number CRD42023452418. Thorough meta-analysis was performed using Comprehensive Meta-Analysis V4 software.

Results

Meta-analysis revealed a significant positive relationship between anxiety and neuroticism, with 26 studies supporting this association (OR = 3.213, 95% CI 2.352 to 4.391). The findings underscore the importance of considering personality traits, particularly neuroticism, in understanding psychological responses to major global crises such as the COVID-19 epidemic.

Discussion

The observed connection between neuroticism and heightened anxiety levels emphasizes the need for targeted interventions, especially for individuals with high levels of neuroticism. Further research into potential therapeutic approaches for mitigating anxiety consequences in the context of a significant global catastrophe is warranted.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/#CRD42023452418.
Trajectories of severe eating disorders through pregnancy and early motherhood
Authors: Sommerfeldt Bente , Skårderud Finn , Kvalem Ingela Lundin , Gulliksen Kjersti , Holte Arne
Published: January 2024

Background

During pregnancy and early motherhood, risks of relapse and worsening are high for women with a history of eating disorders (EDs), as are adverse sequelae for their babies. However, systematic descriptions of the processes that these women undergo through pregnancy, birth, and early motherhood are lacking, as are good descriptions of the various trajectories these women follow through pregnancy and early motherhood. This study addresses both these knowledge gaps.

Methods

We used a longitudinal research interview design, recruiting a non-clinical sample of 24 women with a history of severe EDs from routine pregnancy controls in five public, local, family health care centers in Norway. The participants were interviewed twice, first during pregnancy and then 4–6 months after delivery. Data were analyzed according to grounded theory. The focus was on modeling the trajectories of EDs through pregnancy, birth, and early motherhood. All the participants were diagnosed (DSM-5) using the Eating Disorder Examination and then completed the Eating Disorder Examination Questionnaire.

Results

Five perceived trajectories through pregnancy and early motherhood were identified: “The mastering mother,” in which an ED pathology seems to be absent through pregnancy and early motherhood; “The inadequate mother,” in which the ED pathology worsens before pregnancy, through pregnancy, and early motherhood; “The overwhelmed mother,” in which the ED worsens during pregnancy and early motherhood; “The depressed mother,” in which the ED is put on hold during pregnancy, but worsens in early motherhood; and “The succeeding mother,” in which the ED worsens during pregnancy, but reduces in early motherhood.

Discussion

ED trajectories through pregnancy and early motherhood vary greatly among women with a history of EDs. This may indicate different psychological dynamics through these phases. A model with five trajectories captures a large degree of the variation. The model may help clinicians’ preparedness when dealing with these patients.
Perceived precarious life: a SEM model for re-dimensioning of precarious work and its impact on mental health
Authors: Llosa José Antonio , Agulló-Tomás Esteban , Menéndez-Espina Sara , Rivero-Díaz María Luz
Published: January 2024

Introduction

Precarious work is one of the most studied concepts related to work, and its effects have been analyzed in relation to variables such as mental health and wellbeing. However, there is a tendency to atomise the analysis of precarious work, without understanding that people's working life is intertwined with other areas of their life.

Objective

Faced with this situation, this paper presents the concept of perceived precarious life, which is aligned with contemporary models of social inclusion and exclusion. Thus, perceived precarious life comprises variables of labor precariousness, social support and hopelessness in the family economic situation.

Methods

To test this idea, a structural equation model (SEM) is presented, which tests the structure of the construct of perceived precarious life by relating it to mental health and coping strategies.

Results

After testing the fit of the model in both men and women, a SEM path analysis is designed between the variables, observing that perceived precarious life has an effect on mental health (β = 0.635, p < 0.01). This relationship is mediated by unproductive coping strategies (β = 0.142, p < 0.01).

Conclusion

This model exposes a broad and integrated conceptualization of precariousness, combining aspects of work, relationships and hopelessness, which allows for an understanding of the integral experience of precariousness.
Risk communication and community engagement in the context of COVID-19 response in Bangladesh: a qualitative study
Authors: Kamruzzaman Mohammed , Rahman Aminur , Reidpath Daniel D. , Akhter Sadika
Published: January 2024

Background

The global COVID-19 pandemic profoundly impacted nations worldwide, and Bangladesh was no exception. In response, the government of Bangladesh implemented community awareness initiatives aimed at containing the spread of the virus, aligned with international guidelines and recommendations. Despite these efforts, a lack of comprehensive community awareness programs played an essential role during the pandemic, not the preventive measures. A qualitative study employing framing theory was conducted to gain a deeper insight into how the social context influenced risk communication and community response throughout the COVID-19 pandemic in Bangladesh.

Methods

The study was conducted in four selected districts of Bangladesh from February to May 2022 using complementary data collection methods, including key informant interviews, in-depth interviews, and focus group discussions with purposely selected participants. Data were analyzed thematically by following six steps of the thematic analysis process. Codes were developed based on the data and summarized into themes and sub-themes grounded on the codes.

Results

The findings indicate that the government of Bangladesh, along with development partners and non-government organizations, made a significant effort to raise awareness about COVID-19 in the community. However, there were certain limitations to this effort. These include a lack of social science and public health approaches to understanding the pandemic; inadequate coordination among the authorities for COVID-19 prevention and control; technological and geographical barriers for disseminating messages; the living conditions and lack of facilities; socio-cultural norms in understanding the COVID-19 health messages, and the gendered understanding of the messages. The findings also revealed that the awareness activities remained a one-way approach to inform the people and faced challenges to actively engage and create ownership of the community in the pandemic response.

Conclusion

The study identified gaps in implementing risk communication and community engagement strategies in Bangladesh during the COVID-19 pandemic. Increasing focus on public health and prioritizing community ownership is essential to designing a more effective community awareness campaign. This approach will help ensure that health messages are communicated effectively and tailored to different communities’ needs.
Use of the urine Determine LAM test in the context of tuberculosis diagnosis among inpatients with HIV in Ghana: a mixed methods study
Authors: Åhsberg Johanna , Tersbøl Britt Pinkowski , Puplampu Peter , Kwashie Augustine , Commey Joseph Oliver , Adusi-Poku Yaw , Moseholm Ellen , Andersen Åse Bengård , Kenu Ernest , Lartey Margaret , Johansen Isik Somuncu , Bjerrum Stephanie
Published: January 2024

Background

The urine Determine LAM test has the potential to identify tuberculosis (TB) and reduce early mortality among people living with HIV. However, implementation of the test in practice has been slow. We aimed to understand how a Determine LAM intervention was received and worked in a Ghanaian in-hospital context.

Design/Methods

Nested in a Determine LAM intervention study, we conducted a two-phase explanatory sequential mixed methods study at three hospitals in Ghana between January 2021 and January 2022. We performed a quantitative survey with 81 healthcare workers (HCWs), four qualitative focus-group discussions with 18 HCWs, and 15 in-depth HCW interviews. Integration was performed at the methods and analysis level. Descriptive analysis, qualitative directed content analysis, and mixed methods joint display were used.

Results

The gap in access to TB testing when relying on sputum GeneXpert MTB/Rif alone was explained by difficulties in obtaining sputum samples and an in-hospital system that relies on relatives. The Determine LAM test procedure was experienced as easy, and most eligible patients received a test. HCWs expressed that immediate access to Determine LAM tests empowered them in rapid diagnosis. The HCW survey confirmed that bedside was the most common place for Determine LAM testing, but qualitative interviews with nurses revealed concerns about patient confidentiality when performing and disclosing the test results at the bedside. Less than half of Determine LAM-positive patients were initiated on TB treatment, and qualitative data identified a weak link in the communication of the Determine LAM results. Moreover, HCWs were reluctant to initiate Determine LAM-positive patients on TB treatment due to test specificity concerns. The Determine LAM intervention did not have an impact on the time to TB treatment as expected, but patients were, in general, initiated on TB treatment rapidly. We further identified a barrier to accessing TB treatment during weekends and that treatment by tradition is administrated early in the morning.

Conclusion

The Determine LAM testing was feasible and empowered HCWs in the management of HIV-associated TB. Important gaps in routine care and Determine LAM-enhanced TB care were often explained by the context. These findings may inform in-hospital quality improvement work and scale-up of Determine LAM in similar settings.
A study on Internet use and subjective well-being among Chinese older adults: based on CGSS (2012-2018) five-wave mixed interface survey data
Authors: Zhang Chong , Zhang Yong , Wang Yan
Published: January 2024

Objective

This study is designed to investigate the relationship between Internet use and subjective well-being of the older adults in China, and to analyze the mediating role of subjective social fairness in the above relationship.

Methods

Based on the five-wave mixed interface survey data of China General Social Survey (CGSS) in 2012, 2013, 2015, 2017, and 2018, we select a total of 18,458 older adults aged 60 and above, and comprehensively used ordered probit regression, propensity score matching (PSM), and Karlson-Holm-Breen (KHB) mediating effect test methods.

Results

The analysis results show that (1) Internet use is significantly positively correlated with the subjective well-being of the older adults, and the higher the frequency of use, the stronger the subjective well-being. (2) Place of residence, education, and regional factors moderated the effect of Internet use on subjective well-being. The subjective well-being effect of Internet use is significant among male older adults, as well as on urban, educated, or eastern older adults. (3) Subjective social fairness plays a negative mediating role in the relationship between Internet use and subjective well-being of older adults.

Conclusion

The findings suggest that Internet use contributes to the improvement of subjective well-being in older adults, but attenuates this effect by reducing the subjective social fairness. Future research should further consider other factors such as the purpose, specific function, intensity of Internet use, etc., to gain a deeper understanding of how the Internet can help promote well-being.
Is sleep quality a moderated mediator between perceived stress and depression among stroke patients?
Authors: Guo Lina , Wei Miao , Namassevayam Genoosha , Zhang Mengyv , Xie Yvying , Meng Runtang , Guo Yuanli , Liu Yanjin
Published: January 2024

Background

Sleep quality can offer new insights into addressing depression among stroke patients. However, the current understanding of the mechanism by which sleep quality reduces depression is not clear in existing research.

Objectives

This study aimed to identify the relationships and mechanisms among perceived stress, sleep quality, social support, and depression in stroke patients.

Methods

A multicenter cross-sectional study was conducted from January to May 2023. Cluster random sampling was used to recruit 500 stroke patients from five hospitals in Henan Province, China. The Chinese Perceived Stress Scale (CPSS), Pittsburgh Sleep Quality Index (PSQI), Social Support Rating Scale (SSRS), and Hamilton Depression Scale (HAMD-24) were employed to assess perceived stress, sleep quality, social support, and depression, respectively. Data were analyzed using descriptive analysis, Pearson’s correlation analysis, and moderated mediation analysis. The study adhered to the STROBE checklist for reporting.

Results

Out of 500 participants, 471 completed the survey (94.2%). After controlling for sex and age, mediation analysis revealed that poor sleep quality partially mediated the relationship between perceived stress and depression (β = 0.184, 95% CI: 0.110, 0.359). Additionally, social support played a moderating role in the mediation model.

Conclusion

This study explained the moderated mediation of sleep quality and social support between perceived stress and depression. It provided a theoretical basis for the development of a sleep quality intervention program for reducing depression among stroke patients.
Luxury or normal goods? Evidence from the utilization of institutional care services for the disabled older adults in China
Authors: Xia Xueqing , Li Quanlun
Published: January 2024

Background

Nursing care is essential for older adults with disabilities. Income plays a crucial role in determining the utilization of institutional care services. Pension benefit, as the main source of income for the older adults in China’s cities and towns in their later years, is an important factor influencing the utilization of institutional care services. However, there have been no consistent findings on how pension benefits affect the utilization of institutional care services for the disabled older adults.

Methods

This paper utilizes data from the 2017–2018 Chinese Longitudinal Healthy Longevity Survey. We select disabled older adults aged 65 and older, living in towns and cities, and use a probit regression model to investigate the impact of pension benefits on the utilization of institutional care services by urban disabled older adults empirically.

Results

The study shows that a 1% increase in pension benefits raises the probability that the urban disabled older adults use institutional care services by 0.03. It also finds that for low-income urban disabled older adults, the effect is statistically significantly positive at the 1% level; but for high-income urban disabled older adults, the effect is not statistically significant. The pension benefits significantly increase the probability for the disabled older adults who are male, financially dependent, and live in townships. In addition, the pension benefits significantly reduce the probability that children will provide care and pay for care services for their older parents.

Conclusion

Institutional care service is a normal good for the urban disabled older adults, especially for low-income older adults. Therefore, higher pension benefit raises the probability of utilizing institutional care services for the urban older adults with disabilities, and this positive effect is especially pronounced for older adults who are male, financially dependent, and reside in townships. In addition, increase in the pension benefits for the disabled older adults in towns and cities reduces the burden on children by reducing the probability that children will provide care and pay for care services for the older adults.
Incidence and predictors of chronic kidney disease among patients with diabetes treated at governmental hospitals of Harari Region, eastern Ethiopia, 2022
Authors: Cheru Abera , Edessa Dumessa , Regassa Lemma Demissie , Gobena Tesfaye
Published: January 2024

Background

Chronic kidney disease (CKD) is the leading cause of morbidity and mortality in diabetic patients. However, limited evidence is available about its incidence and predictors in Ethiopia, specifically in the Harari region.

Methods

A retrospective follow-up study was conducted among 520 diabetes patients who followed their treatment at governmental hospitals in the Harari region between 1 September 2012, and 30 May 2022. The risk of developing CKD was calculated with a 95% CI, and the risk was stratified by type of diabetes mellitus. Predictors of CKD were determined using the Gompertz regression model with the baseline Cox model.

Results

Data from 494 patients were included in the final analysis with 26 (5%) excluded. A total of 51 patients (10.32%) developed CKD over the 10-year follow-up period with an incidence rate of 2.16 cases (95% CI 1.64–2.84) per 100 person-years of observation. The risk of CKD was increased by three times (AHR: 3.09, 45 95% CI: 1.56, 6.14) among patients older than 60 years and by more than three times (AHR: 3.53, 95% CI: 1.43, 8.71) among patients with diabetes mellitus for longer than 5 years of stay with the diabetes mellitus. Moreover, the risk of CKD was increased four-fold among patients with high-density lipoprotein cholesterol (HDL-C) levels <40 mg/dL (AHR: 3.84, 95% CI, 1.80–8.18) and those with positive baseline proteinuria (AHR: 3.77, 95% CI: 1.43–8.71).

Conclusion

We found that one in ten diabetic patients had developed CKD within 10 years of the diabetes mellitus diagnosis. Advanced age, longer duration of diabetes, lower baseline HDL-C level, and proteinuria had increased the hazards of developing CKD. We recommend a more focused follow-up of older adult patients with advanced disease status at baseline for optimal control of diabetes mellitus that prevents its furthering to CKD.
Determining the nurses’ perception regarding the effectiveness of COVID-19 protocols implemented in Eastern Province: Saudi Arabia
Authors: Aljaffary Afnan , Al Elaiwi Tahani , AlOtaibi Noot , AlAnsari Fatimah , Alumran Arwa , Salama Khaled F.
Published: January 2024

Background

The global impact of Coronavirus Disease 2019 (COVID-19) has been profound, affecting public health, the global economy, and overall human life. Past experiences with global pandemics underscored the significance of understanding the perception of HCWs and hospital staff in developing and implementing preventive measures. The World Health Organization (WHO) provided protocols to manage the spread of COVID-19 and assist healthcare workers and health systems globally in maintaining high-quality health services.

Objective

This study aims to assess nurses’ perception, awareness, and compliance regarding the implementation of COVID-19 protocols and explore factors influencing their perception.

Methodology

A quantitative cross-sectional survey-based study was conducted, distributing a constructed survey among nurses in the Eastern Province of Saudi Arabia.

Results

Out of 141 participants, most adhered to protocols such as hand sanitization, social distancing, and proper personal protective equipment (PPE) usage. The predominant age group among respondents was 31 to 40 years (n = 71, 50%). A significant portion of participants reported holding a bachelor’s degree (n = 86, 61%), with only 14% possessing advanced degrees (n = 19). Nearly a third of the nurses in the study had accumulated 6 to 10 years of professional experience (n = 49, 34.8%). A noteworthy percentage of nurses were engaged in daily shifts exceeding 8 h (n = 98, 70%). Gender differences were observed, with females exhibiting a higher tendency to avoid shaking hands and social gatherings. Saudi nationals were more inclined to shake hands and engage in gatherings. Non-Saudi nurses and those aged between <25 to 40 years demonstrated proper donning/doffing practices. Nurses with over 6 years of experience avoided social gatherings, while those working >8 h adhered better to PPE usage, proper donning/doffing, and disposal of PPE in designated bins.

Conclusion

Understanding COVID-19 protocols is crucial for tailoring interventions and ensuring effective compliance with COVID-19 preventive measures among nurses. More efforts should be made toward preparing the healthcare nursing to deal with the outbreak. Preparing healthcare nursing with the right knowledge, attitude, and precautionary practices during the COVID-19 outbreak is very essential to patient and public safety.
Associations between cohort derived dementia and COVID-19 serological diagnosis among older Black adults in rural South Africa
Authors: Harriman Nigel Walsh , Bassil Darina T. , Farrell Meagan T. , Du Toit Jacques , Gómez-Olivé Casas F. Xavier , Tollman Stephen M. , Berkman Lisa F.
Published: January 2024

Objectives

This study investigates the association between cohort derived dementia and serologically confirmed SARS-CoV-2 infection, an underexplored phenomena in low-and middle-income countries. Examining this relationship in a rural South African community setting offers insights applicable to broader healthcare contexts.

Methods

Data were collected from Black South Africans in the Mpumalanga province who participated in the Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa. Cohort derived dementia was developed using a predictive model for consensus-based dementia diagnosis. Multinomial logistic regression models estimated the association between predicted dementia probability in 2018 and SARS-CoV-2 infection risk in 2021, controlling for demographics, socioeconomic status, and comorbidities.

Results

Fifty-two percent of the tested participants had serologically confirmed SARS-CoV-2 infections. In the fully adjusted model, cohort derived dementia was significantly associated with over twice the risk of serological diagnosis of COVID-19 (RRR = 2.12, p = 0.045).

Conclusion

Complying with COVID-19 prevention recommendations may be difficult for individuals with impaired cognitive functioning due to their symptoms. Results can inform community-based public health initiatives to reduce COVID-19 transmission among South Africa’s rapidly aging population.
Public health workforce survey data (2016–2021) related to employee turnover: proposed methods for harmonization and triangulation
Authors: Weiss Nicole M. , Martin Skky , Onal Sezen O. , McDaniel Nicole , Leider Jonathon P.
Published: January 2024

Introduction

Public health workforce numbers are unsustainable at best and dire at worst: based on 2017 and 2019 data, 80,000 FTEs needed to be hired by health departments to provide basic public health foundational services before COVID-19 hit, suggesting that the situation is worse after the mass exodus of public health officials due to the pandemic. As such, a better understanding of public health workforce turnover is critical to improving recruitment and retention in the discipline.

Methods

This methods report details how the authors harmonized four public health workforce surveys—the Public Health Workforce Interests and Needs Survey (PH WINS), the National Association of County and City Health Officials (NACCHO) Profile, the NACCHO Forces of Change survey, and the Association of State and Territorial Health Officials (ASTHO) Profile—in order to examine employee turnover.

Results

We found that 31% of the public health workforce reported considering leaving their positions at some time in the future. Furthermore, the majority of agencies reported that zero vacancies had been filled in both 2018 and 2019.

Discussion

These findings suggest that retention, recruitment, and onboarding may be areas upon which to focus evaluation and quality improvement endeavors, allowing public health organizations to better attract and retain the most qualified candidates.
An evolutionary game study on the collaborative governance of environmental pollution: from the perspective of regulatory capture
Authors: Hu Zikun , Wang Yina , Zhang Hao , Liao Wenjun , Tao Tingyu
Published: January 2024

Local governments have been captured by enterprises and, thus, have relaxed environmental regulations. This phenomenon has occurred repeatedly and has resulted in serious environmental pollution, posing an enormous threat to public health. To solve this problem, this study introduces central environmental protection inspection and media supervision and considers the economic preferences and environmental preferences of local governments. A four-party evolutionary game model composed of enterprises, local governments, the central government and the media is constructed, and the equilibrium solution of four-party replicator dynamics equations is obtained. The influence of relevant parameters on the choice of strategies of the four main bodies is simulated by using MATLAB software to explore the paths and measures for overcoming regulatory capture and to further improve the modern environmental governance system. The results show the following: First, local governments are easily captured by large enterprises. Second, the central government can improve the environmental behavior of local governments by reducing their economic preferences and strengthening punishment. Third, compared to the penalties imposed by the central government, those imposed by local governments have a more significant impact on the environmental behaviors of enterprises. Fourth, compared to the use of an environmental protection tax policy or a tax relief policy alone, the combination of the two has a more significant impact on the environmental behaviors of enterprises. Fifth, central environmental protection inspection and media supervision can improve the environmental behaviors of both local governments and enterprises, and the effect of media supervision is better than that of central environmental protection inspection. This study recommends improving the performance evaluation system for local governments to coordinate economic development and environmental protection, ensuring that local governments assume the main responsibility, using a combination of incentive and constraint policies for enterprises, and increasing the environmental protection inspection and media supervision of local governments and enterprises to resolve the dilemma of regulatory capture in environmental pollution through the simultaneous enhancement of the environmental behavior of local governments and enterprises.
Are we saying it right? Communication strategies for fighting vaccine hesitancy
Authors: Di Lorenzo Antonio , Stefanizzi Pasquale , Tafuri Silvio
Published: January 2024

Vaccine hesitancy is a multi-faceted phenomenon, deeply rooted in cultural, socioeconomic and personal background. Communication is deemed fundamental in fighting vaccine hesitancy. Medical communication should be accessible, relying both on an emotional approach and accurate information. Trained professionals should curate communication with the public.
Study on the logic and effectiveness of crisis learning in the promotion policy adjustment: an observation based on the adjustment of COVID-19 prevention policy in China
Authors: Wei Changwei , Xu Jiaxi , Xu Zuying
Published: January 2024

Background

As the impact of COVID-19 on normal production and living conditions diminishes, this serious emergency is come to an end. China’s policy framework has facilitated positive adjustment over the past 3 years by timely modifying its emergency response to changes in viruses and epidemics. This paper aims to explore the logic of China’s policy framework that promoted policy adjustment through crisis learning during COVID-19.

Methods

By gathering and classifying China’s epidemic prevention policies throughout the past 3 years, integrating policy texts, and analyzing key events, this article examines the process of supporting policy adjustment through crisis learning in the policy system during COVID-19.

Results

The Chinese government’s COVID-19 policy adjustment process can be divided into four stages, namely ‘The period of stress response’, ‘The period of COVID-19 prevention and control’, ‘The period of regular prevention and control’, and ‘The period of overall adjustment’. The policy adjustments in each stage demonstrate the logic and effectiveness of crisis learning in the promotion policy adjustment. The study has determined that the motivational logic comprises three crucial elements: security requirements, accountability pressure, and reputation management. The institutional logic encompasses both the organizational and resourceful environments, and the institutional and cultural environment. Additionally, the behavioral logic of policy adaptation aligns with the strategy of crisis learning. Meanwhile, the logical framework of ‘crisis learning-policy adjustment’ can be verified using the Chinese government’s policy adjustment in COVID-19 as an example.

Conclusion

Establishing an effective post-crisis learning system is crucial to improving the effectiveness of crisis response. There is a logical link between crisis learning and policy adjustment. The implementation of policy adjustment needs to be based on the results of crisis learning. Government departments are essential for crisis learning and policy adjustment.
Imaging spectrum of amyloid-related imaging abnormalities associated with aducanumab immunotherapy
Authors: Sotoudeh Houman , Alizadeh Mohammadreza , Shahidi Ramin , Shobeiri Parnian , Saadatpour Zahra , Wheeler C. Austin , Natelson Love Marissa , Tanwar Manoj
Published: January 2024

Alzheimer's Disease (AD) is a leading cause of morbidity. Management of AD has traditionally been aimed at symptom relief rather than disease modification. Recently, AD research has begun to shift focus towards disease-modifying therapies that can alter the progression of AD. In this context, a class of immunotherapy agents known as monoclonal antibodies target diverse cerebral amyloid-beta (Aβ) epitopes to inhibit disease progression. Aducanumab was authorized by the US Food and Drug Administration (FDA) to treat AD on June 7, 2021. Aducanumab has shown promising clinical and biomarker efficacy but is associated with amyloid-related imaging abnormalities (ARIA). Neuroradiologists play a critical role in diagnosing ARIA, necessitating familiarity with this condition. This pictorial review will appraise the radiologic presentation of ARIA in patients on aducanumab.
Prosumer capitalism in the sharing economy: a gender approach to service providers’ experiences in ridesharing platforms
Authors: Castillo-Villar Fernando Rey , Castillo-Villar Rosalia G. , Castillo-Villar Krystel K.
Published: January 2024

Introduction

The study draws on the theory of “prosumer capitalism” to explore the experiences of female drivers in ridesharing platforms.

Methods

Twenty-five phenomenological in-depth interviews were carried out with Mexican female drivers in ridesharing platforms.

Results

The results yielded insights regarding the motives of women to become rideshare drivers, their prosumption experiences, and gender issues related to the job.

Discussion

The study offers a novel gender-based approach to comprehend the status of female service providers as prosumer-as-producers and the diverse risks and challenges they face while working in the sharing economy. In a practical sense, platform designers and marketers can improve the application functions to attend to the specific needs of female drivers and implement inclusive measures to safeguard their integrity and well-being.
Management interventions of pearl millet systems for attaining cereal self-sufficiency in Senegal
Authors: Vieira Junior Nilson , Carcedo Ana Julia Paula , Min Doohong , Diatta Andre Amakobo , Araya Alemie , Prasad P. V. Vara , Diallo Amadiane , Ciampitti Ignacio
Published: January 2024

Critical management interventions to target the yield potential for each environment are key to food security, increasing the resilience of current agricultural systems in Senegal. Cereal production is highly dependent on pearl millet (Pennisetum glaucum L.) rainfed systems as one of the major field crops for smallholders. This study aims to (i) quantify the production of pearl millet at the department level for the last quinquennial (until 2020), (ii) assess the impact of weather (temperature and precipitation) on the millet-based supply of cereal demand, and (iii) investigate, through crop modeling, the impact of millet-based supply of cereal demand by comparing recommended management interventions with smallholder-based strategies at the department level. Millet-based cereal supply–demand was estimated considering the observed population and the supply via the simulated pearl millet production (obtained using the APSIM-Millet model) at the department level from 1990 to 2021. High temperature and low precipitation occurrence presented a frequency of 35% across departments, leading to a reduction in millet production by roughly 6% relative to the normal average for 32 years. Adoption of recommended management showed the potential to increase the millet supply, more than doubling the current cereal supply, closing the current supply–demand gap (89 kg inhabitant−1). Achieving future cereal self-sufficiency will also require an intensification of other cereal production.
Case report: First isolation of Yersinia pseudotuberculosis from the blood of a cat
Authors: Scarpellini Raffaele , Giunti Massimo , Bulgarelli Cecilia , Mondo Elisabetta , Esposito Erika , Assirelli Giammarco , Piva Silvia
Published: January 2024

A 14-year-old female domestic short-haired cat with a diagnosed diabetes mellitus and acromegaly was presented for lethargy and dysorexia. On clinical presentation, the patient showed hyperglycemia, hyperthermia, dull mentation, and dehydration. With the suspicion of an inflammatory or infectious complication of diabetes, she was hospitalized with constant rate infusion of insulin, and empirical ampicillin sulbactam was started. Blood culture revealed positivity for Yersinia pseudotuberculosis and the septic picture was confirmed by blood analysis, with leukocytosis, neutrophilia, and an increased serum amyloid A concentration. The isolated Y. pseudotuberculosis strain showed susceptibility to every antimicrobial tested. During the second day of hospitalization, the onset of hypoglycemia and hypotension was treated with norepinephrine and glucose in fluid therapy. The cat recovered well and was discharged with insulin and amoxicillin-clavulanate. This is the first case of septicemia associated with Y. pseudotuberculosis in a cat, suspected of developing the infection after contact with natural reservoirs such as rodents or birds. This route of transmission should be highlighted especially in relation to the zoonotic potential of the bacteria.
Study on the Deployment of Ultra-Wideband Positioning Base Stations in Pig Farms
Authors: Hu Huiyue , Yang Xiaoling , Liu Renxin , Liu Limin , Hu Haibin
Published: January 2024

A novel indoor positioning method for a pigsty based on ultra-wideband (UWB) technology is proposed via reasonably arranging the base stations and positioning tags, which can provide strong support for the accurate positioning of specific pig pens in the pig house. The distribution of Dilution of Precision (DOP) values is analyzed in different deployment schemes which include the amount, the height, the deployment shape, and the distance of the base stations through positioning simulation. Moreover, the positioning effect of dynamic following positioning, the root-mean-square error (RMSE), and the variance of static positioning are measured. It is noteworthy that the Kalman filtering algorithm is adopted to smooth the dynamic following positioning experimental data for reducing the positioning error. The simulated results show that the DOP values decrease with the increase in height and distance, and these results and laws are consistent with the experimental results. However, the DOP values are best reached when the height is from 1.75 m to 2.75 m, and the distance is over 3.00 m. Furthermore, the DOP values of quadrilateral deployment are smaller than the ones of triangular deployment. In addition, the variance of static positioning and dynamic following positioning is decreased by utilizing the Kalman filtering algorithm. Therefore, the excellent positioning system and its solutions in a pigsty can be provided by our proposed indoor positioning method.
Diagnostic Analysis of Diabatic Heating in an Extreme Rainfall Event in Shandong Province, China
Authors: Jiao Yang , Zhang Meng , Zhang Yuqing , Chu Yingjia
Published: January 2024

This study utilizes data from national ground meteorological observation stations in Shandong province, Fengyun-4 satellite data, and ERA5 reanalysis data. Through the calculation of atmospheric heat source changes, the role of diabatic heating in the occurrence and development of heavy rainfall is revealed. The widespread heavy-to-torrential rainfall event in Shandong province on 25 June 2018 is analyzed as a case study. It was found that a deep and robust southwest jet stream was the key system for the formation of this rainfall event. Satellite cloud images during the peak rainfall period showed vigorous development in the rainfall cloud region. During the concentrated rainfall period and when the low-altitude jet stream strengthened, there was mostly cold advection overhead at the observation station. The low-altitude jet stream transported moisture, increasing the humidity gradient, thus enhancing frontogenesis. The warm advection in the low-altitude jet stream was not the main energy supplier during heavy rainfall, and local temperature variations were the primary contributors to the thermodynamic conditions during the peak rainfall period. The rate of warming caused by the condensation and release of heat from water vapor significantly increased during the concentrated rainfall period. This warming effect played a heating role in the middle and lower layers, and the positive feedback from the latent heat release of water vapor condensation intensified the weather system affecting the rainfall, providing strong thermodynamic and dynamic conditions for heavy rainfall.
An AI-Enabled Bias-Free Respiratory Disease Diagnosis Model Using Cough Audio
Authors: Saeed Tabish , Ijaz Aneeqa , Sadiq Ismail , Qureshi Haneya Naeem , Rizwan Ali , Imran Ali
Published: January 2024

Cough-based diagnosis for respiratory diseases (RDs) using artificial intelligence (AI) has attracted considerable attention, yet many existing studies overlook confounding variables in their predictive models. These variables can distort the relationship between cough recordings (input data) and RD status (output variable), leading to biased associations and unrealistic model performance. To address this gap, we propose the Bias-Free Network (RBF-Net), an end-to-end solution that effectively mitigates the impact of confounders in the training data distribution. RBF-Net ensures accurate and unbiased RD diagnosis features, emphasizing its relevance by incorporating a COVID-19 dataset in this study. This approach aims to enhance the reliability of AI-based RD diagnosis models by navigating the challenges posed by confounding variables. A hybrid of a Convolutional Neural Networks (CNN) and Long Short-Term Memory (LSTM) networks is proposed for the feature encoder module of RBF-Net. An additional bias predictor is incorporated in the classification scheme to formulate a conditional Generative Adversarial Network (c-GAN) that helps in decorrelating the impact of confounding variables from RD prediction. The merit of RBF-Net is demonstrated by comparing classification performance with a State-of-The-Art (SoTA) Deep Learning (DL) model (CNN-LSTM) after training on different unbalanced COVID-19 data sets, created by using a large-scale proprietary cough data set. RBF-Net proved its robustness against extremely biased training scenarios by achieving test set accuracies of 84.1%, 84.6%, and 80.5% for the following confounding variables—gender, age, and smoking status, respectively. RBF-Net outperforms the CNN-LSTM model test set accuracies by 5.5%, 7.7%, and 8.2%, respectively.
Prognostic Impact of Serum β2-Microglobulin Levels in Hodgkin Lymphoma Treated with ABVD or Equivalent Regimens: A Comprehensive Analysis of 915 Patients
Authors: Vassilakopoulos Theodoros P. , Arapaki Maria , Diamantopoulos Panagiotis T. , Liaskas Athanasios , Panitsas Fotios , Siakantaris Marina P. , Dimou Maria , Kokoris Styliani I. , Sachanas Sotirios , Belia Marina , Chatzidimitriou Chrysovalantou , Konstantinou Elianna A. , Asimakopoulos John V. , Petevi Kyriaki , Boutsikas George , Kanellopoulos Alexandros , Piperidou Alexia , Lefaki Maria-Ekaterini , Georgopoulou Angeliki , Kopsaftopoulou Anastasia , Zerzi Kalliopi , Drandakis Ioannis , Dimopoulou Maria N. , Kyrtsonis Marie-Christine , Tsaftaridis Panayiotis , Plata Eleni , Variamis Eleni , Tsourouflis Gerassimos , Kontopidou Flora N. , Konstantopoulos Kostas , Pangalis Gerassimos A. , Panayiotidis Panayiotis , Angelopoulou Maria K.
Published: January 2024

The significance of serum beta-2 microglobulin (sβ2m) in Hodgkin lymphoma (HL) is controversial. We analyzed 915 patients with HL, who were treated with ABVD or equivalent regimens with or without radiotherapy. Sβ2m levels were measured by a radioimmunoassay (upper normal limit 2.4 mg/L). Sequential cutoffs (1.8–3.0 by 0.1 mg/L increments, 3.5 and 4.0 mg/L) were tested along with ROC analysis. The median sβ2m levels were 2.20 mg/L and were elevated (>2.4 mg/L) in 383/915 patients (41.9%). Higher sβ2m was associated with inferior freedom from progression (FFP) at all tested cutoffs. The best cutoff was 2.0 mg/L (10-year FFP 83% vs. 70%, p = 0.001), which performed better than the 2.4 mg/L cutoff (“normal versus high”). In multivariate analysis, sβ2m > 2.0 mg/L was an independent adverse prognostic factor in the whole patient population. In multivariate overall survival analysis, sβ2m levels were predictive at 2.0 mg/L cutoff in the whole patient population and in advanced stages. Similarly, sβ2m > 2.0 mg/L independently predicted inferior HL-specific survival in the whole patient population. Our data suggest that higher sβ2m is an independent predictor of outcome in HL but the optimal cutoff lies within the normal limits (i.e., at 2.0 mg/L) in this predominantly young patient population, performing much better than a “normal versus high” cutoff set at 2.4 mg/L.
Human Papillomavirus Types and Cervical Cancer Screening among Female Sex Workers in Cameroon
Authors: Manga Simon M. , Ye Yuanfan , Nulah Kathleen L. , Manjuh Florence , Fokom-Domgue Joel , Scarinci Isabel , Tita Alan N.
Published: January 2024

Background: Female sex workers (FSWs) are at high risk for sexually transmitted infections (STIs), including infection with human papillomavirus (HPV) and cervical cancer due to occupational exposure. The objective of this study was to estimate the prevalence of HPV, HPV types, and precancerous lesions of the cervix among FSWs in Cameroon. Material and Methods: In this cross-sectional study, FSWs in Cameroon aged 30 years and above were screened for cervical cancer using high-risk HPV testing and genotyping and visual inspection with acetic acid and Lugol’s iodine (VIA/VILI) enhanced using digital cervicography (DC) simultaneously. Those who were positive for VIA/VILI-DC were provided treatment with thermal ablation (TA) immediately for cryotherapy/TA-eligible lesions while lesions meeting the criteria for large loop excision of the transformation zone (LLETZ) were scheduled at an appropriate facility for the LLETZ procedure. HPV-positive FSWs without any visible lesion on VIA/VILI-DC were administered TA. Bivariate analyses were conducted to compare demographic and clinical characteristics. Crude and adjusted logistic regression models were computed for HPV infection status and treatment uptake as outcomes in separate models and their ORs and 95% confidence intervals (95% CI) were reported. Results: Among the 599 FSWs aged 30 years and older that were screened for HPV and VIA/VILI-DC, 62.1% (95% CI: (0.58–0.66)) were positive for one or more HPV types. HPV type 51 had the highest prevalence (14%), followed by types 53 (12.4%) and 52 (12.2%). Type 18 had the lowest prevalence of 2.8% followed by type 16 with 5.2%. In the multivariable model, HIV-positive FSWs were 1.65 times more likely to be infected with HPV compared to their HIV-negative counterparts (AOR: 1.65, CI: 1.11–2.45). A total of 9.9% of the 599 FSWs were positive for VIA/VILI-DC. Conclusion: The prevalence of HPV infection among FSWs in Cameroon is higher than the worldwide pooled FSW prevalence. HPV types 51 and 53 were the most prevalent, while types 18 and 16 were the least prevalent. HIV status was the only variable that was significantly associated with infection with HPV.
Carcinoma In Situ (CIS): Is There a Difference in Efficacy between Various BCG Strains? A Comprehensive Review of the Literature
Authors: Llano Andres , Chan Amy , Kuk Cynthia , Kassouf Wassim , Zlotta Alexandre R.
Published: January 2024

Introduction: Intravesical Bacillus Calmette-Guérin (BCG) immunotherapy is the standard of care for high-risk and intermediate-risk non-muscle-invasive bladder cancer (NMIBC) as well as for Carcinoma in situ (CIS). Evidence supports that the different BCG strains, despite genetic variability, are equally effective clinically for preventing the recurrence and progression of papillary NMIBC. The available evidence regarding possible differences in clinical efficacy between various BCG strains in CIS is lacking. Methods: We reviewed the literature on the efficacy of different BCG strains in patients with CIS (whether primary, secondary, concomitant, or unifocal/multifocal), including randomized clinical trials (RCTs), phase II/prospective trials, and retrospective studies with complete response rates (CRR), recurrence-free survival (RFS), or progression-free survival (PFS) as endpoints. Results: In most studies, being RCTs, phase II prospective trials, or retrospective studies, genetic differences between BCG strains did not translate into meaningful differences in clinical efficacy against CIS, regardless of the CIS subset (primary, secondary, or concurrent) or CIS focality (unifocal or multifocal). CRR, RFS, and PFS were not statistically different between various BCG strains. None of these trials were designed as head-to-head comparisons between BCG strains focusing specifically on CIS. Limitations include the small sample size of many studies and most comparisons between strains being indirect rather than head-to-head. Conclusions: This review suggests that the clinical efficacy of the various BCG strains appears similar, irrespective of CIS characteristics. However, based on the weak level of evidence available and underpowered studies, randomized studies in this space should be encouraged as no definitive conclusion can be drawn at this stage.