bluuebunny/crossref_metadata_2025 huggingface dataset:
An Overview of Paralympic Sport from a Historical and Psychosocial Perspective
Authors: ERSÖZ Gözde , ESEN Serkan
Published: October 2023

The Paralympic Olympic Games initiated within the framework of the Paralympic movement is not well known by the society. Understanding the psychological characteristics of para-athletes and revealing their social position will contribute to coaches, managers and all sports professionals working with these athletes. Based on this idea, in this study, the concept of Paralympics is defined, the history of the Paralympic Olympic Games and statistical information in these games are included, and the psychosocial characteristics of athletes who operate in sports environments as para-athletes are discussed. A narrative based literature review was preferred as a methodology in the study. As a result of the research, it has been seen that para sports have progressed rapidly over the years since the first day of its emergence in the historical process. When the psychological characteristics of para athletes are examined, it is understood that para athletes do sports for reasons such as performing well and winning, looking normal, adapting to injury, defending themselves, fighting against marginalization and encouraging the disabled sports movement. It has been stated that para-athletes who are emotionally stable, have cognitive flexibility and mental endurance, are self-confident, can manage stress and control their emotions are more successful in sports. It has been stated that social support is important for para-athletes when they start sports, but an overprotective structure may negatively affect the psychosocial development of para-athletes. In addition, coaches' communication and leadership skills are important for para-athletes to be successful in sports and persistence in sports.
Investigation of Educational Game-Playing Skills of Preschool Teachers
Authors: AKÇINAR Serpil , ARAK Ramazan
Published: October 2023

This study aims to assess the educational game-playing skill levels of preschool teachers. The survey method, a quantitative research approach, was employed in this study. The study involved 61 preschool teachers from official kindergartens and kindergartens affiliated with the Diyarbakır Provincial Directorate of National Education during the 2022-2023 education period. As the data collection tool, the "Educational Game Playing Skill Observation Scale" was used. The data were analyzed using the SPSS statistical software. Independent Samples T-Test and One-Way ANOVA were utilized for the analyses while the LSD test, a Post-Hoc test, was employed to identify which group contributed to significant differences. It was discovered that preschool teachers' educational game-playing skill levels (x̄=100.47) were at satisfactory levels. In terms of the subscales of the observation scale, preschool teachers demonstrated very good skills in the preparation (x̄=3.60) and game phases (x̄=3.41), while their skills in the evaluation phase (x̄=2.66) were sufficient. There was no significant difference in the game skill levels of preschool teachers based on gender and educational level (p>0.05). The significant difference in skill levels among preschool teachers in the preparation phase, game phase, subscales, and evaluation phase subscale arises from participants with service periods between 21-31 years (p<0.05). In the study, the educational game-playing skills of preschool teachers are considered sufficient. The "preparation phase" and "game phase" exhibit very good levels of skill, while the "evaluation phase" is at satisfactory levels.
Economic feasibility of providing paid medical services by the dental department of a state medical organization
Authors: Losev F. F. , Markina L. A. , Wagner V. D.
Published: October 2023

Depending on the type of dental activity, the greatest financial profit was brought by the work of dentists-therapists and dentists-surgeons, almost  in equal volume. Most of the financial resources were received by the dental department of a medical organization through paid medical  services, which is statistically significant compared to voluntary health insurance and is 1.5-2 times more. In this regard, healthcare organizers  need to intensify their efforts to attract insurance companies to increase the number of voluntary medical insurance contracts
Experience in the use of local wound-healing drugs for lesions of the oral mucosa with removable orthopedic structures
Authors: Proskokova S. V. , Enikeev A. M. , Voronetskaya V. A. , Kutuzov D. N. , Pirogov A. E. , Zarochentseva K. M.
Published: October 2023

Relevance. Chronic mechanical trauma of the oral mucosa is a serious disease that can occur when using removable orthopedic structures of various variations.

Objective. Assessment of the symptoms of patients receiving local therapy, including the use of the domestic drug Superlymf adhesive plates.

Materials and methods. In the course of a clinical study, a comparative analysis of the restoration of the oral mucosa was carried out in 4 groups of patients with different therapy options. A total of 52 people took part in the study. The observation was carried out for 14 days.

Results. It was established that the group of patients who received complex treatment consisting of Metrogil-dental gel and Solcoseryl dental paste, as well as the group that used Superlymf alginate plates, showed the best results.

Conclusion. The data obtained by us allow us to implement this treatment regimen for faster recovery of the mucous membrane in the presence of an injury from removable orthopedic structures.
Clinical aspects of the use of a vascularized mucoperiosteal palatine flap for the reconstruction of soft tissue defects
Authors: Magomedova Kh. M. , Domenyuk D. A. , Kochkonyan T. S. , Dmitriyenko D. S. , Domenyuk S. D. , Sletova V. A. , Vintaev V. D. , Boyko E. M. , Sletov A. A.
Published: October 2023

Dental implantation, as a high-tech innovative direction in modern dentistry, can significantly increase the effectiveness of complex rehabilitation of patients with partial and complete loss of teeth. Methods for surgical treatment of patients with soft tissue deficiency in the area of dentition defects must meet the following requirements: minimally invasive; biological feasibility; predictability; the validity of the patterns of changes in the state of soft tissue structures of the maxillofacial during surgical intervention; the need to restore the morphological and functional components of the donor and recipient beds; the most careful attitude to the bone and soft tissue components of the alveolar crest of the jaws for subsequent dental implantation. The article presents the results of a multi-stage method for restoring soft tissue deficiency in 29 patients aged 37 to 60 years with terminal and included defects in the alveolar part of the lower jaw in the distal region using the developed surgical method for eliminating soft tissue deficiency with a vascularized muco-periosteal flap modeled in the projection of the hard palate. The effectiveness of the developed surgical technique is confirmed by clinical data characterizing the intensity of the postoperative inflammatory process, taking into account the developed criteria indicators, as well as morphological indicators of soft tissues in the projection of the apex of the alveolar part of the lower jaw in the area of dentition defects before and 3, 6, 9, 12 months after surgery. It was established that on the 30th day from the moment of surgical manipulations, the intensity of clinical manifestations of the postoperative inflammatory process in the studied patients was completely absent, and by the 12th month, the increase in the thickness of the soft tissue component in the region of the apex of the alveolar part of the lower jaw in the intervention area increased by 133.3%, at the same time, the value of soft tissue growth ranged from 2.2 mm to 3.7 mm. The analysis of the obtained results revealed the high efficiency of the developed method, allowing to expand the indications for dental implantation.
IMPLEMENTASI AUGMENTED REALITY BERBASIS FILTER INSTAGRAM PADA PENERAPAN MEDIA PEMBELAJARAN TENTANG PENGENALAN TATA SURYA
Authors: Satria Dhimas Adi , B. Firmansyah Rokhmatullah , Akbarsyah Basuki Aditya
Published: October 2023

Kebutuhan akan media interaktif dalam pembelajaran mulai diminati oleh masyarakat luas dan seiring dengan meningkatnya penggunaan Smartphone pada saat seperti ini Augmented Reality (AR) merupakan media baru dalam proses pembelajaran IPA anak dalam mengenal planet-planet. dalam Tata Surya dan dapat mengatasi permasalahan dari media pembelajaran tradisional yang ada saat ini yang dirasa kurang informatif dan interaktif bagi anak-anak, dari fungsi penggunaan media edukasi yang dapat memvisualisasikan berbagai objek dan informasi yang dapat membangkitkan rasa ingin tahu pada siswa sehingga anak dapat mulai lebih aktif dalam belajar. Dengan teknologi Augmented Reality (AR), bertujuan agar anak-anak dapat langsung memvisualisasikan imajinasi anaknya tentang planet-planet. Media pembelajaran multimedia 3D interaktif dengan teknologi Augmented Reality berbasis Instagram ini dibuat dengan Software Blender 3D 2.93, Spark AR Studio 141 Hasil dari penelitian ini adalah aplikasi media pembelajaran Augmented Reality tata surya berbasis filter Instagram
RANCANG BANGUN APLIKASI TRACKING BERBASIS WEBSITE PADA PT ABCDE
Authors: Izzulhaq Akbar Bintang , Azizul Akbar Ananda , Setya Putra Rizky Firman , Firdiansyah Alif , Rahmawati Endra
Published: October 2023

PT. ABCDE is a service company operating in the field of goods delivery and online purchases. Currently, PT. ABCDE aims to improve its services and quality standards in various aspects within the company, including the utilization of information technology. Currently, the existing services do not utilize a tracking application to obtain real-time information about the current location of the goods, causing a lack of transparency and inconsistencies in data across different departments. Additionally, the current process of generating delivery notes is manual, time-consuming, and leads to delays for drivers in delivering goods. Therefore, there is a need for a tracking application that records and displays real-time information about the current location of the goods, inputted by the drivers. Additionally, the application should automate the generation of delivery notes to reduce delays. This system will be designed using the PHP programming language and the Laravel framework, utilizing a MySQL server database that allows access from anywhere and anytime. The benefits obtained from this system include facilitating each department, especially the administrative team and owner, in checking the current location of the goods, and ensuring transparency of data across different departments to avoid any misinformation.
THE INFLUENCE OF FINANCIAL LITERACY AND LOCUS OF CONTROL ON FINANCIAL MANAGEMENT BEHAVIOR IN MICRO, SMALL AND MEDIUM ENTERPRISES IN BIMA CITY
Authors: Huda Nurul , Pratiwi Aliah , Munandar Aris , Nurul Rahmatia Nafisah , Amalo Fitrianingsih
Published: October 2023

This study aims to see whether Financial Literacy has an effect on Financial Management Behavior of MSME Actors in Bima City, Does Locus Of Control affect Financial Management Behavior of MSME Actors in Bima City, and which of the variables Financial Literacy and Locus of Control have an influence dominance of Financial Management Behavior in UMKM Actors in the City of Bima. This research was conducted on SMEs in the City of Bima for 6 (six) months. The research method used is explanatory research using a sample survey approach. Conventionally, explanatory research is used to explain the relationship between variables through hypothesis testing. The population in this study was 3,218 MSME actors with a sample of 34 MSME actors in Bima City using a purposive sampling technique, where the questionnaire was tested for validity and reliability and then processed using SPSS so that the accuracy of the analysis tool could be reliable. The results showed that Financial Literacy had an effect on Financial Management Behavior on MSMEs in Bima City while Locus Of Control had no effect on Financial Management Behavior on MSMEs in Bima City. smallest significance (0.000),
THE INFLUENCE OF PACKAGING AND PROMOTION ON THE PURCHASE DECISION OF TEMPE CHIPS IN SUNGAI LANGKAI SUB-DISTRICT, BATAM
Authors: Evyanto Winda , Saputra Asron , Rustam Triana Ananda
Published: October 2023

This study aims to describe the results of research on the Effects of Packaging and Promotion on the Purchase Decision of Tempe Chips from Home Industry in Sungai Langkai  , Sagulung District, Batam.  in addition to the importance of improving quality in terms of content, it needs special attention from various parties, both from the government and the private sector. , as well as universities as many universities have done through community service activities. This research focuses on looking at the implementation of packaging and promotion strategies. The research method used is quantitative research, the data source is 100 consumers of tempeh chips in Sungai Langkai  , Sagulung District, Batam City. Data collection by observation, interviews and documentation, and data analysis by domain data analysis. The results of the discussion show that the labeling and packaging of the decision to buy tempeh chips in the Sungai Langkai sub-district, Sagulung sub-district, can be carried out well even though they are still traditional, but from time to time have changed for the better
Pendampingan Penguatan Kompetensi Guru SMA, MA, dan SMK Melalui Pengembangan Multiple-Solution Task dalam Pembelajaran Matematika di Kabupaten Klaten Jawa Tengah
Authors: Toyib Muhamad , Sari Christina Kartika , Rejeki Sri , Fatmasari Lina Wahyu Sri
Published: October 2023

Pengabdian kepada masyarakat ini bertujuan untuk: (a) memperkenalkan bagaimana merancang multiple-solution task dalam pembelajaran matematika bagi guru-guru SMA/SMK Muhammadiyah di Klaten dan sekitarnya; (b) menyelenggarakan lokakarya dan pelatihan guru dalam merancang multiple-solution task dalam topic geometri analitik. Pelatihan dilaksanakan di SMA Muhammadiyah 1 Klaten, Jawa Tengah. Pesertanya adalah para guru SMA/SMK Muhammadiyah di Klaten dan sekitarnya. Hal itu dilakukan melalui tahapan sebagai berikut: persiapan, terdiri dari koordinasi internal dan eksternal; tahap implementasi yang meliputi pengenalan dan pelatihan desain tugas solusi ganda dalam pembelajaran matematika. Kegiatan bakti sosial ini diikuti 24 guru dari 17 sekolah Muhammadiyah di Klaten. Peserta telah dilatih secara teknis dengan pengalaman baru merancang multiple-solution task dan mengembangkan multiple-solution task dalam topik geometri analitis; para peserta terlibat penuh selama pelatihan. Ada umpan balik dan kebutuhan untuk peningkatan dalam mengintegrasikan multiple-solution task dalam pembelajaran matematika.
OPTIMALISASI PERAN PETUGAS KESEHATAN SEBAGAI UPAYA PENINGKATAN MUTU PELAYANAN UNTUK MENINGKATKAN KESEHATAN IBU HAMIL
Authors: Yanti Ni Luh Gede Puspita , Oktaviani Ni Putu Wiwik , Faidah Nurul , Muliawati Ni Kadek , Adiputra I Made Sudarma
Published: October 2023

Kualitas kesehatan ibu hamil di Indonesia masih belum cukup baik, terbukti masih tingginya Angka Kematian Ibu (AKI) akibat komplikasi selama kehamilan maupun proses persalinan. Petugas kesehatan yang secara tidak langsung terlibat dalam upaya meningkatkan derajat kesehatan ibu hamil melalui pemeriksaan ANC di antaranya adalah perawat, tenaga Ahli Teknologi Laboratorium Medis (ATLM), dan seorang staf perekam medis dan informasi kesehatan. Mutu pelayanan yang optimal untuk meningkatkan kesehatan ibu hamil, memerlukan peran aktif semua komponen petugas kesehatan. Tujuan kegiatan ini untuk mengoptimalkan peran petugas kesehatan khususnya perawat, ATLM serta Staf perekam medis dan informasi kesehatan sebagai upaya peningkatan mutu pelayanan untuk meningkatkan kesehatan ibu hamil. Metode yang digunakan diawali dengan pemaparan atau sharing informasi yang dilaksanakan secara daring tentang pelayanan pada ibu hamil oleh perawat, ATLM dan perekam medis dan informasi kesehatan.. Tahap kedua yaitu FGD untuk memperoleh gambaran pelaksanaan peran petugas kesehatan di RSU Dharma Yadnya. Tahap akhir yaitu pemberian APD kepada petugas kesehatan untuk mendukung pelaksanaan pelayanan kesehatan untuk ibu hamil. Hasil kegiatan diperoleh bahwa seluruh petugas kesehatan sudah menjalankan perannya dengan kategori baik yaitu peran perawat dengan rata-rata  95, peran ATLM dengan rata-rata 93,3 serta peran perekam medis dan informasi kesehatan dengan rata-rata 95. Masih ada beberapa peran yang belum dilaksanakan secara optimal. Petugas kesehatan agar dapat memberikan pelayanan kesehatan dengan menggunakan pengetahuan dan keterampilannya sesuai dengan kompetensi masing-masing sehingga dapat meningkatkan mutu pelayanan kesehatan kepada ibu hamil dan keluarga.
Pengenalan Media Pembelajaran Berbasis Internet Dan E-Learning Pada Anak-Anak Di Perum Green View Kota Batam
Authors: Fauzi Rahmat , Arista Anggia , Tipa Handra , Wangdra Yvonne , Azwanti Nurul , Putria Narti Eka
Published: October 2023

Pengabdian ini bertujuan untuk memperkenalkan media pembelajaran berbasis internet dan e-learning kepada anak-anak di Perum Green View Kota Batam. Dalam era digital saat ini, media pembelajaran berbasis internet dan e-learning memiliki potensi besar untuk meningkatkan efektivitas pembelajaran anak-anak. Melalui pengabdian ini, kami akan memberikan pemahaman kepada anak-anak mengenai penggunaan teknologi dalam proses pembelajaran.  Kegiatan pengabdian akan melibatkan pendekatan interaktif dan partisipatif, seperti pengenalan berbagai platform e-learning, permainan edukatif online, dan sumber daya pembelajaran digital yang relevan. Kami juga akan memberikan panduan kepada anak-anak dan orang tua tentang keamanan dan etika dalam menggunakan internet.  Dengan menggunakan media pembelajaran berbasis internet dan e-learning, diharapkan anak-anak di Perum Green View Kota Batam dapat mengembangkan keterampilan digital mereka, meningkatkan minat mereka dalam pembelajaran, dan memperluas pengetahuan mereka. Pengabdian ini juga diharapkan dapat membantu anak-anak menghadapi tantangan masa depan yang semakin terhubung dengan teknologi.  Pengabdian ini akan memberikan manfaat jangka panjang bagi anak-anak, orang tua, dan masyarakat sekitar. Diharapkan mereka dapat memanfaatkan media pembelajaran berbasis internet dan e-learning sebagai sarana pembelajaran yang efektif dan membangun komunitas belajar yang aktif di Perum Green View Kota Batam.
Pembinaan Pembuatan dan Pengelolaan Website Pelaku Usaha Sablon Lebah Gougle
Authors: Rasid Ridho Muhammat , Fajrah Nofriani , Humaira Humaira , Fifi Fifi , Wangdra Ronald
Published: October 2023

Lebah Gougle adalah sebuah industry rumahan yang menyediakan layanan dalam berbagai bidang seperti mencetak, memotret, membuat video, mencetak sablon, mengurus dokumen, dan lain-lain. Saat ini, fokus utama mereka adalah di bidang percetakan, khususnya dalam memproduksi kaos, baju, topi, stiker, poster, mug, piring, dan barang-barang promosi lainnya.Terdapat permasalahan: kurangnya pengetahuan tentang tempat pembelian domain dan hosting, bagaimana membuat website yang disimpan di hosting, bagaimana mengisi konten dari website tersebut serta mengenai pemeliharan dari website. Solusi yang pengabdi tawarkan: mencoba memberi langkah dalam pemilihan nama domain, pelatihan dalam penyewaan hosting yang cocok kebutuhan, pemilihan CMS (Content Manajemen System) yang cocok dengan usaha ini, pemasangan CMS pada hosting yang sudah dipesan, pelatihan untuk merubah tampilan dari website. Tentang konten website dengan memperhatikan dengan tata bahasa formal dan baik dan yang sesuai dengan ejaan yang di sempurnakan. Pelatihan bagaimana cara mengelakukan backup data web dari sebuah hosting. Hasil dari pengabdian ini, pemilik usaha sablon ini memiliki kemampuan dalam pemilihan nama domain dan hosting. Pemilik usaha mampu dalam manajemen data dan dalam personalisasi website. Pelaku usaha mempunyai kemampuan dalam peletakan gambar dan teks, desain dam layout. Objek pembinaan dapat melakukan pemelihaaan website.
Dunia Teknologi Informasi & Revolusi Industri 4.0
Authors: Jufri Muhammad , Aranski Alvendo Wahyu , Munir Zainul , Candra Joni Eka , Permatasari Ririt Dwiputri , Masril Muhammad Abrar , Kremer Hendri
Published: October 2023

Perkembangan ilmu pengetahuan dan teknologi yang semakin pesat pada awal abad 20 telah melahirkan teknologi informasi dan proses produksi yang dikendalikan secara otomatis. Sebagaimana yang dihadapi Indonesia saat ini, revolusi industri 4.0 telah mendorong inovasi-inovasi teknologi yang memberikan dampak disrupsi atau perubahan fundamental terhadap kehidupan masyarakat. Siklus perputaran evolusi yang akan terus ditapaki oleh masyarakat diseluruh kalangan dapat menciptakan inovasi-inovasi baru yang berpengaruh terhadap perkembangan bisnis. Berbagai situs dalam pengaplikasian teknologi digital memberikan kemudahan untuk mengkoordinir setiap input dan output pelaku bisnis. Kehadiran tech industry diberbagai bidang dapat dimanfaatkan untuk menghidupkan kembali beberapa bisnis yang sudah exsist dimasa lampau. Keseluruhan aspek yang berkaitan dengan teknologi akan memonitoring cepat atau lambatnya dunia digital memasuki ranah laju ekonomi, serta meminimalisasikan fungsi fisik manusia
Tingkat Risiko Kawasan Rawan Banjir di Kecamatan Komodo Kabupaten Manggarai Barat
Authors: Lede Olandina De Rosari , Shofwan Moch.
Published: October 2023

Komodo District is also one of the areas that is prone to disasters, especially floods, as happened in 2019 when a flood hit three villages, namely Gorontalo Village, Macang Tanggar Village and Golo Bilas Village, Komodo District. The purpose of this study was to determine the risk level of flood-prone areas in Komodo District, West Manggarai Regency. Methods of data collection in this study using documentation, observation, literature studies and related institutions. The analytical method used is quantitative descriptive analysis with overlay analysis techniques. The results showed that based on the results of the risk assessment analysis for West Manggarai Regency, the index for the flood hazard class for Komodo District was the moderate class index. This is in line with the results of research conducted where the Komodo District is included in the moderate risk level.
Pengaruh Persepsi, Pengetahuan Akuntansi Dan Skala Usaha Terhadap Penggunaan Informasi Akuntansi Pada Usaha Mikro Kecil Dan Menengah
Authors: Dachi Asti Murni , Purba Mortigor Afrizal
Published: October 2023

This study aims to determine the effect of perception, accounting knowledge and business scale on the use of accounting information on micro, small and medium enterprises. The information gathering strategy is an overview survey of 100 respondents. The method used is a different examination and the type of exploration used in this study is a review technique. the results of the hypothesis test, the perception variable has a significant influence on the use of accounting information with a t count value of 2.422 > t table 1.660, and Sig 0.017 <0.05, accounting knowledge variable obtains a t count value of -0.085 < t table 1.660, and Sig 0.573> 0 .05, so it can be concluded that the accounting knowledge variable does not have a significant effect on the use of accounting information. The business scale variable obtained a t count value of 0.682  0.05. So it can be concluded that the business scale variable has no significant influence on the use of accounting information. Based on the results of the hypothesis test, the calculated f value is 5.859 > f table 2.699 and Sig 0.001 <0.05. Therefore, it can be inferred that Ho is rejected and Ha is accepted, or, in other words, that the End Match independent variables simultaneously have a significant impact on the dependent variable.
Optimalisasi Proses Administrasi Layanan Asuransi Oleh PT Jasa Raharja Kota Batam
Authors: Sihombing Betty Krisdayanti S , Dompak Timbul
Published: October 2023

The of this research emphasis is to assist researchers in understanding the problem under study using the indicator Optimization of the Insurance Service Administration Process by Pt Jasa Raharja Batam City optimization of the insurance service administration process by PT Jasa Raharja Batam City. According to Articles 1 to 24 of Law/22 of 2009 a traffic accident is an unexpected and unintentional incident on the highway involving two or more vehicles colliding with each other or vehicles with no other road users, where the risks of accidents include minor injuries, serious injuries, death, and only experiencing property loss experienced by one or even both victims. Qualitative research methodology was applied in this study. To describe facts and information in the field, such as social activities, attitudes, events, and beliefs that have occurred or have not occurred at the research site, qualitative research methods are used. Optimization of Insurance Service Administration Process by PT Jasa Raharja Batam City PT Jasa Raharja Batam City cooperates with the police and district/city regional governments in order to improve services for the general public who own motorized vehicles and utilize other road facilities. 33 of 1964 concerning obligatory fees and donations to be collected and collected and then redistributed to people who have had accidents, as insurance for raharja services. Jasa raharja insurance is the protection and guarantee of the state to its people who have an accident, while the object is humans and this insurance provides guarantees against losses caused by accidents.
Bacterial outer membrane vesicles as drug delivery carrier for photodynamic anticancer therapy
Authors: Jiang Yuan , Zhou ZunZhen , Liu Chongzhi , Wang Limei , Li Chun
Published: October 2023

Photodynamic Therapy (PDT) is an effective tumor treatment strategy that not only induces photocytotoxicity to kill tumor cells directly but also activates the immune system in the body to generate tumor-specific immunity, preventing cancer metastasis and recurrence. However, some limitations of PDT limit the therapeutic efficacy in deep tumors. Previous studies have used different types of nanoparticles (NPs) as drug carriers of photosensitizers (PSs) to overcome the shortcomings of PDT and improve therapeutic efficacy. Among them, bacterial outer membrane vesicles (OMVs) have natural advantages as carriers for PS delivery. In addition to the targeted delivery of PSs into tumor cells, their unique immunogenicity helps them to serve as immune adjuvants to enhance the PDT-induced immune effect, providing new ideas for photodynamic anticancer therapy. Therefore, in this review, we will introduce the biogenesis and anticancer functions of OMVs and the research on them as drug delivery carriers in PDT. Finally, we also discuss the challenges and prospects of OMVs as a versatile drug delivery carrier for photodynamic anticancer therapy.
The effect of ivabradine therapy on dilated cardiomyopathy patients with congestive heart failure: a systematic review and meta-analysis
Authors: Yang Juntao , Lv Tingting , Zhou Jiedong , Lin Hui , Zhao Bingjie , Lou Haifei , Liu Hanxuan , Zhang Tao , Guo Hangyuan , Chi Jufang
Published: October 2023

Background

Ivabradine improves cardiac function in patients with heart failure, but its effect on dilated cardiomyopathy (DCM) remains unclear. We performed a systematic review and meta-analysis to study the efficacy and potential mechanisms of ivabradine's effect on cardiac function and prognosis in patients with DCM.

Methods

We searched PubMed, Cochrane Library, Embase, Web of Science, and four registers through September 28, 2022. All controlled trials of ivabradine for the treatment of DCM with congestive heart failure were included. Articles were limited to English, with the full text and necessary data available. We performed random- or fixed effects meta-analyses for all included outcome measures and compared the effect sizes for outcomes in patients treated with and without ivabradine. The quality of the studies was assessed using the Cochrane risk-of-bias tool for randomized trials (RoB2.0).

Findings

Five trials with 357 participants were included. The pooled risk ratio was 0.48 [95% confidence interval (CI) (0.18, 1.25)] for all-cause mortality and 0.38 [95% CI (0.12, 1.23)] for cardiac mortality. The pooled mean difference was −15.95 [95% CI (−19.97, −11.92)] for resting heart rate, 3.96 [95% CI (0.99, 6.93)] for systolic blood pressure, 2.93 [95% CI (2.09, 3.77)] for left ventricular ejection fraction, −5.90 [95% CI (−9.36, −2.44)] for left ventricular end-systolic diameter, −3.41 [95% CI (−5.24, −1.58)] for left ventricular end-diastolic diameter, −0.81 [95% CI (−1.00, −0.62)] for left ventricular end-systolic volume, −0.67 [95% CI (−0.86, −0.48)] for left ventricular end-diastolic volume, −11.01 [95% CI (−19.66, −2.35)] for Minnesota Living with Heart Failure score, and −0.52 [95% CI (−0.73, −0.31)] for New York Heart Association class.

Interpretation

Ivabradine reduces heart rate and ventricular volume, and improves cardiac function in patients with DCM, but showed no significant effect on the prognosis of patients.
Governance and digital transformation in schools with 1:1 tablet coverage
Authors: Tømte Cathrine E. , Smedsrud Jørgen Hammer
Published: October 2023

There is an increasing trend of 1:1 coverage of tablets in schools in Scandinavia. Several studies have reported on pedagogical possibilities and challenges, but less is reported about how this change is perceived and practised by other stakeholders. We interviewed public school owners and leaders in Norway and found school owners used various models to support their schools, and school leaders held varied views on their roles in promoting the implementing 1:1 coverage in schools. Considering these findings, we discuss whether establishing overall national guidelines might help school owners and school leaders to effect digital transformation in schools and whether such guidelines would support or counteract school leaders’ autonomy and ability to adapt the digital transformation to their local context.
A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass
Authors: Hernández-Montoliu Laura , Rodríguez-Peña M-Mar , Puig Rocío , Astiarraga Brenno , Guerrero-Pérez Fernando , Virgili Nuria , López-Urdiales Rafael , Osorio Javier , Monseny Rosa , Lazzara Claudio , Sobrino Lucía , Pérez-Maraver Manuel , Pérez-Prieto María , Pellitero Silvia , Fernández-Veledo Sonia , Vendrell Joan , Vilarrasa Nuria
Published: October 2023

Objective

To determine changes in incretins, systemic inflammation, intestinal permeability and microbiome modifications 12 months after metabolic RYGB (mRYGB) in patients with type 2 diabetes (T2D) and their relationship with metabolic improvement.

Materials and methods

Prospective single-center non-randomized controlled study, including patients with class II-III obesity and T2D undergoing mRYGB. At baseline and one year after surgery we performed body composition measurements, biochemical analysis, a meal tolerance test (MTT) and lipid test (LT) with determination of the area under the curve (AUC) for insulin, C-peptide, GLP-1, GLP-2, and fasting determinations of succinate, zonulin, IL-6 and study of gut microbiota.

Results

Thirteen patients aged 52.6 ± 6.5 years, BMI 39.3 ± 1.4 kg/m2, HbA1c 7.62 ± 1.5% were evaluated. After mRYGB, zonulin decreased and an increase in AUC after MTT was observed for GLP-1 (pre 9371 ± 5973 vs post 15788 ± 8021 pM, P<0.05), GLP-2 (pre 732 ± 182 vs post 1190 ± 447 ng/ml, P<0.001) and C- peptide, as well as after LT. Species belonging to Streptococaceae, Akkermansiacea, Rickenellaceae, Sutterellaceae, Enterobacteriaceae, Oscillospiraceae, Veillonellaceae, Enterobacterales_uc, and Fusobacteriaceae families increased after intervention and correlated positively with AUC of GLP-1 and GLP-2, and negatively with glucose, HbA1c, triglycerides and adiposity markers. Clostridium perfringens and Roseburia sp. 40_7 behaved similarly. In contrast, some species belonging to Lachnospiraceae, Erysipelotricaceae, and Rumnicocaceae families decreased and showed opposite correlations. Higher initial C-peptide was the only predictor for T2D remission, which was achieved in 69% of patients.

Conclusions

Patients with obesity and T2D submitted to mRYGB show an enhanced incretin response, a reduced gut permeability and a metabolic improvement, associated with a specific microbiota signature.
Research on construction and management strategy of carbon neutral stadiums based on CNN-QRLSTM model combined with dynamic attention mechanism
Authors: Ma Chunying , Xu Yixiong
Published: October 2023

Introduction

Large-scale construction projects such as sports stadiums are known for their significant energy consumption and carbon emissions, raising concerns about sustainability. This study addresses the pressing issue of developing carbon-neutral stadiums by proposing an integrated approach that leverages advanced convolutional neural networks (CNN) and quasi-recurrent long short-term memory (QRLSTM) models, combined with dynamic attention mechanisms.

Methods

The proposed approach employs the CNN-QRLSTM model, which combines the strengths of CNN and QRLSTM to handle both image and sequential data. Additionally, dynamic attention mechanisms are integrated to adaptively adjust attention weights based on varying situations, enhancing the model's ability to capture relevant information accurately.

Results

Experiments were conducted using four datasets: EnergyPlus, ASHRAE, CBECS, and UCl. The results demonstrated the superiority of the proposed model compared to other advanced models, achieving the highest scores of 97.79% accuracy, recall rate, F1 score, and AUC.

Discussion

The integration of deep learning models and dynamic attention mechanisms in stadium construction and management offers a more scientific decision support system for stakeholders. This approach facilitates sustainable choices in carbon reduction and resource utilization, contributing to the development of carbon-neutral stadiums.
Quantitative wood anatomy and stable carbon isotopes indicate pronounced drought exposure of Scots pine when growing at the forest edge
Authors: Buras Allan , Rehschuh Romy , Fonti Marina , Lange Jelena , Fonti Patrick , Menzel Annette , Gessler Arthur , Rigling Andreas , Treydte Kerstin , von Arx Georg
Published: October 2023

Climate change poses a major threat to global forest ecosystems. In particular, rising temperatures and prolonged drought spells have led to increased rates of forest decline and dieback in recent decades. Under this framework, forest edges are particularly prone to drought-induced decline since they are characterized by warmer and drier micro-climatic conditions amplifying impacts of drought on tree growth and survival. Previous research indicated that forest-edge Scots pine trees have a higher growth sensitivity to water availability compared to the forest interior with consequent reduction of canopy greenness (remotely sensed NDVI) and higher mortality rates. Yet, the underlying physiological mechanisms remain largely unknown. Here, we address this knowledge gap by comparing stable carbon isotope signatures and wood anatomical traits in annual rings of trees growing at the forest edge vs. the forest interior and between trees that either survived or died during the extreme drought of 2015. Our analyses suggest that the exposure to drought of forest-edge Scots pine likely results in a reduction of stomatal conductance, as reflected by a higher δ13C of stem wood, thinner cell walls, and lower mean ring density. Moreover, we found dead trees to feature larger mean hydraulic lumen diameters and a lower cell-wall reinforcement, indicating a higher risk to suffer from cavitation. In conclusion, the typically drier micro-climatic conditions at the forest edge seem to have triggered a larger reduction of stomatal conductance of Scots pine trees, resulting in a lower carbon availability and significantly altered wood anatomical properties under an increasingly drier climate.
Construction and validation of a novel senescence-related risk score can help predict the prognosis and tumor microenvironment of gastric cancer patients and determine that STK40 can affect the ROS accumulation and proliferation ability of gastric cancer cells
Authors: Sun Weijie , Yuan Yihang , Chen Jiaying , Bao Qun , Shang Mengsi , Sun Peng , Peng Haixia
Published: October 2023

Background

In recent years, significant molecules have been found in gastric cancer research. However, their precise roles in the disease’s development and progression remain unclear. Given gastric cancer’s heterogeneity, prognosis prediction is challenging. This study aims to assess patient prognosis and immune therapy efficacy using multiple key molecules.

Method

The WGCNA algorithm was employed to identify modules of genes closely related to immunity. A prognostic model was established using the Lasso-Cox method to predict patients’ prognosis. Single-sample gene set enrichment analysis (ssGSEA) was conducted to quantify the relative abundance of 16 immune cell types and 13 immune functions. The relationship between risk score and TMB, MSI, immune checkpoints, and DNA repair genes was examined to predict the effectiveness of immune therapy. GO and KEGG analyses were performed to explore potential pathways and mechanisms associated with the genes of interest. Single-cell RNA sequencing was utilized to investigate the expression patterns of key genes in different cell types.

Results

Through the WGCNA algorithm and Lasso-Cox algorithm selected KL, SERPINE1, and STK40 as key genes for constructing the prognostic model. The SSGSEA algorithm was employed to evaluate the infiltration of immune cells and immune functions in different patients, and their association with the risk score was investigated. The high-risk group exhibited lower TMB and MSI compared to the low-risk group. MMR and immune checkpoint analysis revealed a significant correlation between the risk score and multiple molecules. Finally, we also believe that STK40 is the most critical senescence-related gene affecting the progression of gastric cancer. In vitro experiments showed that ROS accumulation and cell proliferation ability of gastric cancer cells were impaired when STK40 was knocked down.

Conclusion

In summary, we’ve constructed a prognostic model utilizing key genes for gastric cancer prognosis, while also showcasing its efficacy in predicting patient response to immunotherapy.
Potential therapeutic effect of olfactory ensheathing cells in neurological diseases: neurodegenerative diseases and peripheral nerve injuries
Authors: Zhang Li-peng , Liao Jun-xiang , Liu Yi-yi , Luo Hong-lang , Zhang Wen-jun
Published: October 2023

Neurological diseases are destructive, mainly characterized by the failure of endogenous repair, the inability to recover tissue damage, resulting in the increasing loss of cognitive and physical function. Although some clinical drugs can alleviate the progression of these diseases, but they lack therapeutic effect in repairing tissue injury and rebuilding neurological function. More and more studies have shown that cell therapy has made good achievements in the application of nerve injury. Olfactory ensheathing cells (OECs) are a special type of glial cells, which have been proved to play an important role as an alternative therapy for neurological diseases, opening up a new way for the treatment of neurological problems. The functional mechanisms of OECs in the treatment of neurological diseases include neuroprotection, immune regulation, axon regeneration, improvement of nerve injury microenvironment and myelin regeneration, which also include secreted bioactive factors. Therefore, it is of great significance to better understand the mechanism of OECs promoting functional improvement, and to recognize the implementation of these treatments and the effective simulation of nerve injury disorders. In this review, we discuss the function of OECs and their application value in the treatment of neurological diseases, and position OECs as a potential candidate strategy for the treatment of nervous system diseases.
Drifting in the deep: Metatranscriptomics and metabarcoding reveal sustained metabolic activity and community composition in hydrothermal vent plume microbial communities
Authors: Polinski Jennifer M. , Rodrigue Mattie , Meyer Jason D. , Harke Matthew J.
Published: October 2023

The deep sea is the largest habitat on our planet, supporting a vast diversity of organisms which have yet to be fully described. This habitat is punctuated by hydrothermal vents in which energy derived from chemosynthesis drives carbon fixation, supporting a complex and rich food web. Connectivity between vent systems remains an active area of research, with questions as to how vent-influenced microbial function and diversity persists over space and time. In particular, the role hydrothermal vent plumes play as potential highways for connectivity and biogeography is not well understood. To add to the growing body of research, this study sampled plume waters above the Moytirra hydrothermal vent field, located just north of the Azores. We examined how hydrothermal vent plume community biodiversity and metabolic activities change with distance from the vent using a combination of metabarcoding and metatranscriptomic sequencing. We detected a rich diversity of both prokaryotic and eukaryotic organisms inhabiting the plume, which remained metabolically active for kilometers from the vent source. Enriched sulfur metabolism functional signals and relative abundance of sulfur oxidizing bacteria suggest reduced sulfur compounds are a fundamental energy source within plume waters. Additionally, we observed evidence of top-down controls on primary production through both known grazers and putative viral activity. Although community-level functional signals suggest active metabolic functions for over a kilometer north or south of the vent field, these functions grew increasingly dissimilar to those observed directly above the vent site, and bacterial communities displayed indications of entering quiescent stages, likely due to decreasing resources and reduced temperatures. These data provide a first glimpse of Moytirra’s microbial biodiversity, in addition to providing a high-resolution understanding of life on the drift within a hydrothermal plume, its persistence with distance, and implications for connectivity.
Correlation between metabolomic profile and proliferation of Macrobrachium rosenbergii primary embryonic cell culture
Authors: Sudarshan Gurucharan , Weil Simy , Jasińska Weronika , Manor Rivka , Goldstein Oron , Aflalo Eliahu D. , Ofir Rivka , Zimin Sean V. , Levy Tom , Rosental Benyamin , Brotman Yariv , Sagi Amir
Published: October 2023

Despite extensive research spanning several decades, a commercial cell line for prawns remains elusive, and we have yet to determine the ideal conditions required for successful in vitro cell cultures of crustaceans. This study marks the first application of mass spectrometry to analyze lipid content changes in prawn culture media, allowing us to investigate how specific metabolites in media correlate with cell cycle and proliferation status. To investigate these relationships, short-term cell culture experiments were conducted using three commercial media: Dulbecco's modified eagle medium (DMEM) high glucose, Opti-Minimal essential media (Opti-MEM), and DMEM:F12. We monitored metabolic activity, performed cell-cycle analysis, and used mass spectrometry to analyze lipid metabolic profiles of culture media. This comprehensive approach enables us to examine the interplay between media lipidomic content and cellular behavior. Our results revealed that all three media sustained cellular metabolic activity. DMEM high glucose and Opti-MEM showed peaks in metabolic activity at day 4, while DMEM:F12 exhibited a peak at day 7. Opti-MEM supported the shortest doubling time, making it ideal for short-term culture. Interestingly, DMEM high glucose retained more attached cells on day 1 and had the highest count on day 4, with a noticeable trend towards the G2/M cell-cycle phase. Moreover, our lipidomic analysis of Opti-MEM revealed significantly higher concentrations of 26 annotated lipids compared to the other media. Notably, lipids like phosphatidylcholine and phosphatidylserine were consistently abundant in all three media, and palmitate levels correlated with proliferation phase. These findings have significant implications for establishing sustainable crustacean cell culture lines. Understanding the lipidomic compositions and their associations with cell-cycle dynamics and proliferation allows for precise conditioning of culture media to promote sustainable growth and delay cellular entry into quiescence phases. This knowledge contributes to the long-term goal of maintaining robust prawn cell cultures for various research and biotechnological applications.
Simulation of sonar reverberation signal considering the ocean multipath and Doppler effect
Authors: Zhang Sen , Wu Jian , Yin Tianqi
Published: October 2023

In order to achieve accurate modeling and simulation of sonar reverberation signals, four types of multi-path underwater reverberation models are established considering Doppler effect under the condition of separating the sound source and hydrophone. The simulation of underwater reverberation signals under static or uniform linear motion conditions is carried out for single point for the separating the sound source and hydrophone transceiver, as well as horizontal linear array. The non-stop-and-hop model of reverberation signals is presented. And the underwater reverberation signals in the array element domain and beam domain are obtained. From the simulation results of the improved model, it can be seen that the spatiotemporal two-dimensional characteristics and Doppler expansion are consistent with theoretical analysis. The frequency shift of the horizontal linear array reverberation signal is approximately sinusoidal with the directionality angle of the linear array. Comparing the simulation results of the improved model with traditional models, the improved model can more accurately simulate sonar reverberation signals.
Research on properties of basalt fiber-reinforced asphalt mastic
Authors: Shi Chenglin , Wang Jianan , Sun Shuang , Lv Dongye , Xu Lina , Zhang Sufeng
Published: October 2023

A basalt fiber-reinforced asphalt mixture can improve the engineering properties of asphalt pavement and prolong the service life of the road. However, few studies have systematically examined the composition of asphalt mixtures or the optimal ratio of fiber asphalt mastic suitable for different structural types. The effects of fiber content, filler–asphalt ratio, and asphalt viscosity on the properties of fiber asphalt mastic were investigated by orthogonal experiments to explore the reinforcement effect of basalt fiber on asphalt mastic. The optimal ratio of fiber asphalt mastic suitable for gap-graded and dense-graded asphalt mixtures was obtained by the fuzzy comprehensive evaluation (FCE) method. Meanwhile, the reinforcement effects of bundled basalt fiber (BBF), flocculated basalt fiber (FBF), polyester fiber (PF), and lignin fiber (LF) on asphalt mastic were compared and analyzed based on the optimal ratio of FBF asphalt mastic. The results showed that the optimal fiber asphalt mastic ratio suitable for gap-graded and dense-graded asphalt mixtures were that fiber content, filler–asphalt ratio, and asphalt viscosity were 3%, 1.8, and 1.1 Pa·s and 2%, 1.0, and 0.7 Pa·s, respectively. Analyzing the properties of different types of fiber asphalt mastic revealed that FBF could effectively enhance the high-temperature rheological properties and low-temperature tensile properties of asphalt mastic compared with other fibers. FBF asphalt mastic improved the asphalt rutting factor by more than four times. The tensile fracture energy of fiber asphalt mastic was more than three times that of the corresponding asphalt. The reinforcement effect of BBF was poor; it was recommended to be broken up before use.