bluuebunny/crossref_metadata_2025 huggingface dataset:
Barriers to and facilitators of the implementation of pharmacist services in primary care clinics: a scoping review protocol
Authors: Li Haixin , Liang Xujian , Wang Yang , Lu Yiting , Deng Zhiling , Ye Yuanqu , Qian Yi , Guo Yi , Xu Zhijie
Published: January 2022

Introduction

Inappropriate medication use is a leading cause of avoidable harm in health systems and is particularly severe in primary care settings. Evidence has shown that the integration of pharmacists into primary care clinics has favourable satisfaction and effectiveness in health outcomes. However, barriers to and facilitators of pharmacist services in these settings have not been comprehensively reviewed. Therefore, this scoping review aims to map and examine the literature available on the barriers to and facilitators of the implementation of pharmacist services in primary care clinics to guide future implementation research.

Methods and analysis

This scoping review will be undertaken following the six-stage framework developed by Arksey and O’Malley and be guided by recommendations by Levac et al. Eight electronic databases (PubMed, Embase, Scopus, Web of Science, CINAHL, PsycINFO, CNKI and Wanfang) will be searched. Reference lists and related citations, and grey literature from websites will be searched manually. Available information that has been reported in Chinese or English up to 31 August 2021 will be included. Studies will be selected and screened by two reviewers independently. Findings from the included studies will be extracted by two independent reviewers and supervised by a third reviewer. A content analysis of the findings will be performed using MAXQDA 2020.

Ethics and dissemination

Ethical approval will not be required for this scoping review, as all data and information will be obtained from publicly available literature. The findings of this scoping review will be shared with healthcare managers in primary care institutions and health authorities as well as disseminated via publication in a peer-reviewed journal.
Anaemia prevalence and its associated factors in children under 5 years in Western China: a systematic review
Authors: Du Yefan , Liao Ying , Leng Fangqun , Li Linhua , Ye Ruixue , Mao Yuping , Raat Hein , Zhou Huan
Published: January 2022

Background

Iron-deficiency anaemia disproportionately affects children in low-income and middle-income areas; Western China is a prime example. Given the health risks associated with childhood anaemia and the large heterogeneity of published studies on this subject, we conducted a systematic review of the evidence regarding anaemia prevalence and associated factors in children under 5 years in Western China.

Methods

We searched for all relevant studies on the prevalence of iron deficiency anaemia in children under 5 years in Western China, obtaining research between 1 January 2011 and 30 June 2021, in English and Chinese from Medline, Embase, PubMed, Web of Science, CNKI, WanFang Data and VIP. Two reviewers independently screened titles and abstracts; three reviewed full texts of relevant articles for data extraction and performed quality assessments. The median prevalence was calculated on unweighted pooling, stratified by region, sex, age and ethnic group. Associated factors and a linear trend chart were conducted to identify trends and research highlights.

Results

Among the 55 articles included, most were cross-sectional studies (39, 70.91%). The prevalence of anaemia in children under 5 years in Western China ranged from 3.69% to 75.74% (median 42.54% (IQR 25.62%–52.56%)); the highest levels were in Qinghai province: 59.10%–75.74% (median 67.80% (IQR 64.70%–72.75%)); the highest levels were reported in the subgroup of children aged 6–12 months (median 50.09% (IQR 34.35%–59.04%)). Regional contexts, individual sociodemographic characteristics and feeding behaviours, and nutritional programme interventions were factors associated with anaemia prevalence.

Conclusion

The prevalence of anaemia in children under 5 years in Western China is concerningly high. For this multiethnic and economically underdeveloped region, more high-quality and prospective studies are needed to inform evidence based and targeted preventive strategies to decrease the high prevalence of anaemia among young children.
Reducing the harms of unsafe abortion: a systematic review of the safety, effectiveness and acceptability of harm reduction counselling for pregnant persons seeking induced abortion
Authors: Stifani Bianca Maria , Gill Roopan , Kim Caron Rahn
Published: January 2022

Background

Globally, access to safe abortion is limited. We aimed to assess the safety, effectiveness and acceptability of harm reduction counselling for abortion, which we define as the provision of information about safe abortion methods to pregnant persons seeking abortion.

Methods

We searched PubMed, EMBASE, ClinicalTrials.gov, Cochrane, Global Index Medicus and the grey literature up to October 2021. We included studies in which healthcare providers gave pregnant persons information on safe use of abortifacient medications without providing the actual medications. We conducted a descriptive summary of results and a risk of bias assessment using the ROBINS-I tool. Our primary outcome was the proportion of pregnant persons who used misoprostol to induce abortion rather than other methods among those who received harm reduction counselling.

Results

We included four observational studies with a total of 4002 participants. Most pregnant persons who received harm reduction counselling induced abortion using misoprostol (79%–100%). Serious complication rates were low (0%–1%). Uterine aspiration rates were not always reported but were in the range of 6%–22%. Patient satisfaction with the harm reduction intervention was high (85%–98%) where reported. We rated the risk of bias for all studies as high due to a lack of comparison groups and high lost to follow-up rates.

Discussion

Based on a synthesis of four studies with serious methodological limitations, most recipients of harm reduction counselling use misoprostol for abortion, have low complication rates, and are satisfied with the intervention. More research is needed to determine abortion success outcomes from the harm reduction approach.

Funding

This work did not receive any funding.

PROSPERO registration number

We registered the review in the PROSPERO database of systematic reviews (ID number: CRD42020200849).
Antitumor activity and safety of camrelizumab plus famitinib in patients with platinum-resistant recurrent ovarian cancer: results from an open-label, multicenter phase 2 basket study
Authors: Xia Lingfang , Peng Jin , Lou Ge , Pan Mei , Zhou Qi , Hu Wenjing , Shi Huirong , Wang Li , Gao Yunong , Zhu Jianqing , Zhang Yu , Sun Rong , Zhou Xianfeng , Wang Quanren , Wu Xiaohua
Published: January 2022

Background

Combination treatments with immune-checkpoint inhibitor and antiangiogenic therapy have the potential for synergistic activity through modulation of the microenvironment and represent a notable therapeutic strategy in recurrent ovarian cancer (ROC). We report the results of camrelizumab (an anti-programmed cell death protein-1 antibody) in combination with famitinib (a receptor tyrosine kinase inhibitor) for the treatment of platinum-resistant ROC from an open-label, multicenter, phase 2 basket trial.

Methods

Eligible patients with platinum-resistant ROC were enrolled to receive camrelizumab (200 mg every 3 weeks by intravenous infusion) and oral famitinib (20 mg once daily). All patients had disease progression during or <6 months after their most recent platinum-based chemotherapy. Primary endpoint was confirmed objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) V.1.1 based on investigator’s assessment. Secondary endpoints included disease control rate (DCR), duration of response (DoR), time to response (TTR), progression-free survival (PFS), overall survival (OS), 12-month OS rate and safety profile.

Results

Of the 37 women enrolled, 11 (29.7%) patients had primary platinum resistant, 15 (40.5%) patients had secondary platinum resistant and 11 (29.7%) patients had primary platinum refractory disease. As the cut-off date of April 9, 2021, nine (24.3%) patients had achieved a confirmed objective response, the ORR was 24.3% (95% CI, 11.8 to 41.2) and the DCR was 54.1% (95% CI, 36.9 to 70.5). Patients with this combination regimen showed a median TTR of 2.1 months (range, 1.8–4.1) and a median DoR of 4.1 months (95% CI, 1.9 to 6.3). Median PFS was 4.1 months (95% CI, 2.1 to 5.7), and median OS was 18.9 months (95% CI, 10.8 to not reached), with the median follow-up duration of 22.0 months (range, 12.0–23.7). The estimated 12-month OS rate was 67.2% (95% CI, 49.4 to 79.9). The most common ≥grade 3 treatment-related adverse events were hypertension (32.4%), decreased neutrophil count (29.7%) and decreased platelet count (13.5%). One (2.7%) patient died of grade 5 hemorrhage that was judged possibly related to study treatment by investigator.

Conclusion

The camrelizumab with famitinib combination appeared to show antitumor activity in heavily pretreated patients with platinum-resistant ROC with an acceptable safety profile. This combination might provide a novel alternative treatment strategy in platinum-resistant ROC setting and warranted further exploration.

Trial registration number

NCT03827837.
Colours, capsules and concept flavour names on cigarette packs appeal to youth in Mexico
Authors: Brown Jennifer L , Grilo Graziele , Cohen Joanna E , Clegg Smith Katherine , Reynales-Shigematsu Luz Myriam , Flores Escartin Maria Guadalupe , Moran Meghan Bridgid
Published: January 2022

Background

Flavoured cigarettes are popular in Mexico. We examined how cigarette packaging design features used to communicate flavour influence perceptions of appeal, harm, perceived interest and pack preference among Mexico City residents.

Methods

We conducted an experimental survey. Participants aged 13–34 years were randomly assigned to one of three conditions, viewed packs with systematically manipulated design features (colour, capsule image and flavour name) and answered questions on appeal, perceived harm, perceived interest and pack preference. Data were analysed using mixed effects and conditional logistic regression.

Results

1500 adolescents and 950 adults participated. Regardless of flavour, cigarette packs with a background colour and capsule image were more appealing to adolescents (OR=13.19, 95% CI 11.53 to 15.10; OR=1.68, 95% CI 1.45 to 1.88) and adults (OR=4.18, 95% CI 3.73 to 4.69; OR=1.66, 95% CI 1.49 to 1.85) than packs without. Among adolescents, ‘Tropical Burst’ named packs were more appealing (OR=1.43, 95% CI 1.20 to 1.72) than packs without a flavour name and among adults, ‘Arctic Air’ named packs were more appealing (OR=1.20, 95% CI 1.02 to 1.14). Adolescents and adults reported a preference for trying packs that displayed a flavour name, background colour or capsule image (b=0.104, b=0.702, b=1.316, p<0.001 and b=0.126, b=0.619, b=0.775, p<0.001).

Conclusions

Colours and flavour capsule images appeal to adolescents and adults in Mexico. Mexico should consider adopting plain packaging to reduce appeal and interest.
Short- to medium-term effects of crown and surface fires on soil respiration in a Canadian boreal forest
Authors: Ribeiro-Kumara Caius , Santín Cristina , Doerr Stefan H. , Pumpanen Jukka , Baxter Greg , Köster Kajar
Published: January 2022

Fires are an important perturbation for the carbon (C) dynamics of boreal forests, especially when they are stand-replacing. In North American boreal forests, crown fires are predominant and, therefore, the most studied. However, surface fires can also lead to major tree mortality with substantial implications for the C balance. Here, we assess the short- (hours to days) to medium-term (1–3 years) effects of the different fire types (surface vs. crown) on the postfire soil C effluxes in jack pine (Pinus banksiana Lamb.) and black spruce (Picea mariana (Mill.) BSP) forest stands in the Northwest Territories, Canada. We found that while trees were instantly killed by the four crown fires studied, trees also died within 1 year after two of three surface fires studied. Associated with this tree mortality, soil autotrophic respiration decreased after both fire types, although at different timings. The soil heterotrophic respiration was either lower or unchanged when measured 1–3 years after either fire type but was increased when measured immediately after a surface fire, possibly due to the interaction between ash generation and wetting performed to suppress the fire. Our results suggest that both fire types can thus substantially alter C fluxes in the short to medium term, both through changes in vegetation and the soil environment.
Numerical investigation of the effect of hole reaming on fatigue life by cold expansion
Authors: Liu Kuanyu , Yang Xinsheng , Zhou Li , Li Ming , Zhu Weijin
Published: January 2022

The reaming process of a 6061 aluminum alloy plate after cold expansion with a split sleeve was simulated by the finite element (FE) method based on Abaqus/CAE, and the relationship between the reaming depths and the distribution of residual stress fields was obtained by analysis. The fatigue lives of the plates under different reaming depths were calculated using the fatigue analysis software FE-SAFE and verified by fatigue tests. The results showed that reaming after expansion increased the residual compressive stress at the hole edge on the entrance surface. In addition, the fatigue life of the specimens increased with increasing reaming depth, and the best fatigue gain of the specimen was obtained when the reaming depth was 0.5 mm.
CNN with Multiple Inputs for Automatic Glaucoma Assessment Using Fundus Images
Authors: Elmoufidi Abdelali , Skouta Ayoub , Jai-Andaloussi Said , Ouchetto Ouail
Published: January 2022

In the area of ophthalmology, glaucoma affects an increasing number of people. It is a major cause of blindness. Early detection avoids severe ocular complications such as glaucoma, cystoid macular edema, or diabetic proliferative retinopathy. Intelligent artificial intelligence has been confirmed beneficial for glaucoma assessment. In this paper, we describe an approach to automate glaucoma diagnosis using funds images. The setup of the proposed framework is in order: The Bi-dimensional Empirical Mode Decomposition (BEMD) algorithm is applied to decompose the Regions of Interest (ROI) to components (BIMFs+residue). CNN architecture VGG19 is implemented to extract features from decomposed BEMD components. Then, we fuse the features of the same ROI in a bag of features. These last very long; therefore, Principal Component Analysis (PCA) are used to reduce features dimensions. The bags of features obtained are the input parameters of the implemented classifier based on the Support Vector Machine (SVM). To train the built models, we have used two public datasets, which are ACRIMA and REFUGE. For testing our models, we have used a part of ACRIMA and REFUGE plus four other public datasets, which are RIM-ONE, ORIGA-light, Drishti-GS1, and sjchoi86-HRF. The overall precision of 98.31%, 98.61%, 96.43%, 96.67%, 95.24%, and 98.60% is obtained on ACRIMA, REFUGE, RIM-ONE, ORIGA-light, Drishti-GS1, and sjchoi86-HRF datasets, respectively, by using the model trained on REFUGE. Again an accuracy of 98.92%, 99.06%, 98.27%, 97.10%, 96.97%, and 96.36% is obtained in the ACRIMA, REFUGE, RIM-ONE, ORIGA-light, Drishti-GS1, and sjchoi86-HRF datasets, respectively, using the model training on ACRIMA. The experimental results obtained from different datasets demonstrate the efficiency and robustness of the proposed approach. A comparison with some recent previous work in the literature has shown a significant advancement in our proposal.
Synthesis of 2D Heterostructures: MOS2/GO and MOS2/Graphene via Microdrop and CVD Deposition
Authors: Horst Diogo José , Duvoisin Charles Adriano , De Almeida Vieira Rogério , Arizpe Jesús Alejandro , Segovia Esther Alejandra Huitrón , García-García Alejandra
Published: January 2022

The main objective of this work was to study the synthesis and characteristics of two-dimensional heterostructures (2D/2D) using pure molybdenum disulfide (MoS[Formula: see text] and doped with phosphorus at 5% and 15% combined with graphene oxide (GO) and graphene monolayer. These were deposited on silicon and copper substrates using two different deposition methods: Microdrop casting and chemical vapor deposition. Chemical and structural information of the samples were characterized by Raman spectroscopy, Energy Dispersion X-ray Spectroscopy (EDS), Scanning Electron Microscopy (SEM) and Kelvin Probe Force Microscopy (KPFM). The results prove the synergy between the materials resulting in electronic coupling, making this system potential for applications in electronic devices such as sensors, resistors and capacitors.
The principles of helium exploration
Authors: Danabalan Diveena , Gluyas Jon G. , Macpherson Colin G. , Abraham-James Thomas H. , Bluett Josh J. , Barry Peter H. , Ballentine Chris J.
Published: January 2022

Commercial helium systems have been found to date as a serendipitous by-product of petroleum exploration. There are nevertheless significant differences in the source and migration properties of helium compared with petroleum. An understanding of these differences enables prospects for helium gas accumulations to be identified in regions where petroleum exploration would not be tenable. Here we show how the basic petroleum exploration playbook (source, primary migration from the source rock, secondary longer distance migration, trapping) can be modified to identify helium plays. Plays are the areas occupied by a prospective reservoir and overlying seal associated with a mature helium source. This is the first step in identifying the detail of helium prospects (discrete pools of trapped helium). We show how these principles, adapted for helium, can be applied using the Rukwa Basin in the Tanzanian section of the East African Rift as a case study. A thermal hiatus caused by rifting of the continental basement has resulted in a surface expression of deep crustal gas release in the form of high-nitrogen gas seeps containing up to 10%
4
He. We calculate the total likely regional source-rock helium generative capacity, identify the role of the Rungwe volcanic province in releasing the accumulated crustal helium and show the spatial control of helium concentration dilution by the associated volcanic CO
2
. Nitrogen, both dissolved and as a free-gas phase, plays a key role in the primary and secondary migration of crustal helium and its accumulation into what might become a commercially viable gas pool. This too is examined. We identify and discuss evidence that structures and seals suitable for trapping hydrocarbon and CO
2
gases will likely also be efficient for helium accumulation on the timescale of the Rukwa Basin activity. The Rukwa Basin prospective recoverable P
50
resources of helium have been independently estimated to be about 138 BSCF (billion standard cubic ft: 2.78 × 10
9
 m
3
at STP). If this volume is confirmed it would represent about 25% of the current global helium reserve. Two exploration wells, Tai 1 and Tai 2, completed by August 2021 have proved the presence of seal and reservoir horizons with the reservoirs containing significant helium shows.

This article is part of the Energy Geoscience Series available at
https://www.lyellcollection.org/cc/energy-geoscience-series
Toward Polymorphic Internet of Things Receivers Through Real-Time Waveform-Level Deep Learning
Authors: Restuccia Francesco , Melodia Tommaso
Published: January 2022

Wireless systems such as the Internet of Things (IoT) are changing the way we interact with the cyber and the physical world. As IoT systems become more and more pervasive, it is imperative to design wireless protocols that can effectively and efficiently support IoT devices and operations. On the other hand, today's IoT wireless systems are based on inflexible designs, which makes them inefficient and prone to a variety of wireless attacks. In this paper, we introduce the new notion of a deep learning-based polymorphic IoT receiver, able to reconfigure its waveform demodulation strategy itself in real time, based on the inferred waveform parameters. Our key innovation is the introduction of a novel embedded deep learning architecture that enables the solution of waveform inference problems, which is then integrated into a generalized hardware/software architecture with radio components and signal processing. Our polymorphic wireless receiver is prototyped on a custom-made software-defined radio platform. We show through extensive over-the-air experiments that the system achieves throughput within 87% of a perfect-knowledge Oracle system, thus demonstrating for the first time that polymorphic receivers are feasible.
The Measurement of Mixed Potentials Using Platinum Decorated Nanoporous Gold Electrodes
Authors: Islam Md. Shafiul , Branigan Alan J. , Ullah Borkat , Freeman Christopher J. , Collinson Maryanne M.
Published: January 2022

Potentiometric redox sensing in solutions containing multiple redox molecules was evaluated using in-house constructed nanoporous gold (NPG)-platinum (Pt) and unmodified NPG electrodes. The NPG-Pt electrode was fabricated by electrodepositing Pt into the nanoporous framework of a chemically dealloyed NPG electrode. By varying the concentration of the Pt salt and the electrodeposition time, different amounts of Pt were introduced. Characterization by SEM shows the pore morphology doesn’t change with the addition of Pt and XPS indicates the electrodes contain ∼2.5–24 wt% Pt. Open-circuit potential (OCP) measurements in buffer and solutions containing ascorbic acid, cysteine, and/or uric acid show that the OCP shifts positive with the addition of Pt. These results are explained by an increase in the rate of the oxygen reduction reaction with the addition of Pt. The overall shape of the potentiometric titration curves generated from solutions containing one or more bioreagents is also highly dependent on the amount of Pt in the nanoporous electrode. Furthermore, the generation of OCP vs Log [bioreagent] from the results of the potentiometric experiments shows an ∼2-fold increase in sensitivity can result with the addition of Pt. These results indicate the promise that these electrodes have in potentiometric redox sensing.
Industry Viable Electrochemical DNA Detection Sensor Architecture via a Stem-Loop Methylene Blue Redox Reporter and Rapid In Situ Probe Immobilization Method for Pharmacogenetic Biomarker Testing Application
Authors: Jayawardena Asanka , Tan Sher Maine , Richardson Mark B. , Chan Jianxiong , Thissen Helmut , Voelcker Nicolas H. , Kwan Patrick
Published: January 2022

Identification of biomarkers in clinical applications for diagnostics at the point-of-care (POC) setting requires the development of industry viable biosensing platform. Herein, we report such development of biosensor architecture for the detection of pharmacogenetic biomarker HLA-B*15:02 gene. The biosensor architecture comprises of an oligonucleotide stem-loop probe modified with a methylene blue redox (MB) reporter, immobilized via a rapid “printing” method on the commercially available disposable screen-printed electrodes (SPE). The square wave voltammetric measurements on the DNA sensor showed a clear peak difference of ∼80 nA with a significant difference in peak height values of the faradaic current generated for the MB redox moiety between the positive control (biotin-modified 19 based oligonucleotides with the sequence mimicking the specific region of the HLA-B*15:02 allele and complementary to the probe sequence) and negative control samples (biotin-modified 19 based oligonucleotides with the sequence unrelated to the probe sequence and the HLA-B*15:02 allele). These initial proof of concept results provide support for the possibility of using this signal-off biosensor architecture in the intended pharmacogenetic biomarker testing.
SnO2-TiO2 and SnO2-MoO3 Based Composite Gas Sensors to Develop an E-nose for Peruvian Pisco Varieties Differentiation
Authors: Bravo-Hualpa F. , Trevejo-Pinedo J. , Visurraga K. , Pinedo-Flores A. , Acuña K. , Peña-Echevarría J. , Rojas F. , De-La-Cruz C. , Sun-Kou M. R.
Published: January 2022

There is great interest in the development of a simple system that could identify adulteration or counterfeiting of Peruvian Pisco (a grape-based alcoholic drink). In this study, sensors based on SnO2-TiO2 and SnO2-MoO3 composites with different weight composition ratios were synthesized and characterized. These sensors were tested with aqueous solutions of EtOH/MeOH and Pisco samples of Italia and Quebranta varieties in order to explore their capacity to identify variations in these beverages. The response profile of the most sensitive sensors showed an enhanced response to alcoholic samples with greater content of ethanol up to a concentration of 45%v/v, while the increased content of methanol in the range of 0.1 to 0.3% v/v diminished the intensity of the sensor response. Differences in the composition of methanol and ethanol in the Pisco varieties studied (Italia and Quebranta) were correlated to the capacity of the composite-based sensors to differentiate them with greater performance. Sensors based on SnO2-TiO2-1/2 composites showed greater reproducibility in their response profile over time in comparison to SnO2-TiO2-1/1 and SnO2-MoO3 composites. The PCA showed that composite sensors were able to differentiate Pisco samples according to the varieties, Italia and Quebranta.
Generalized Poisson-Nernst-Planck-Based Physical Model of the O2∣LSM∣YSZ Electrode
Authors: Miloš Vojtěch , Vágner Petr , Budáč Daniel , Carda Michal , Paidar Martin , Fuhrmann Jürgen , Bouzek Karel
Published: January 2022

The paper presents a generalized Poisson-Nernst-Planck model of an yttria-stabilized zirconia electrolyte developed from first principles of nonequilibrium thermodynamics which allows for spatial resolution of the space charge layer. It takes into account limitations in oxide ion concentrations due to the limited availability of oxygen vacancies. The electrolyte model is coupled with a reaction kinetic model describing the triple phase boundary with electron conducting lanthanum strontium manganite and gaseous phase oxygen. By comparing the outcome of numerical simulations based on different formulations of the kinetic Eqs. with the results of EIS and CV measurements we attempt to discern the existence of separate surface lattice sites for oxygen adatoms and surface oxides from the assumption of shared ones. Moreover, we show that the mass-action kinetics model is sensitive to oxygen partial pressure unlike exponential kinetics models. The resulting model is fitted to a dataset of EIS and CVs spanning multiple temperatures and pressures, using various relative weights of EIS and CV data in the fitness function. The model successfully describes the physics of the interface around the OCV.
Terminal Deoxynucleotidyl Transferase Extension-Dominated In Situ Signal Attenuation-Free Electrochemical Platform and Its Logic Gate Manipulation
Authors: Wang Qi , Hao Tingting , Hu Kaiyue , Qin Lingxia , Ren Xinxin , Guo Zhiyong , Wang Sui , Hu Yufang
Published: January 2022

Signal generation of traditional electrochemical biosensors suffers from the random diffusion of electroactive probes in a electrolyte solution, which is accompanied by poor reaction kinetics and low signal stability from complex biological systems. Herein, a novel circuit system with autonomous compensation solution ohmic drop (noted as “fast-scan cyclic voltammetry (FSCV)”) is developed to solve the above problems, and employed to achieve terminal deoxynucleotide transferase (TdT) and its small molecule inhibitor analysis. At first, a typical TdT-mediated catalytic polymerization in the conditions of original DNA, deoxythymine triphosphate (dTTP) and Hg2+ is applied for the electrode assembly. The novel electrochemical method can provide some unattenuated signals due to in situ Hg redox reaction, thus improving reaction kinetics and signal stability. This approach is mainly dependent on TdT-mediated reaction, so it can be applied properly for TdT investigation, and a detection limit of 0.067 U ml−1 (S/N = 3) is achieved successfully. More interesting, we also mimic the function of TdT-related signal communication in various logic gates such as YES, NOT, AND, N-IMPLY, and AND-AND-N-IMPLY cascade circuit. This study provides a new method for the detection of TdT biomarkers in many types of diseases and the construction of a signal attenuation-free logic gate.
Perspective—Electrochemistry in Understanding and Designing Electrochemical Energy Storage Systems
Authors: Xiao Jie , Anderson Cassidy , Cao Xia , Chang Hee-Jung , Feng Ruozhu , Huang Qian , Jin Yan , Job Heather , Kim Ju-Myung , Le Phung M. L. , Liu Dianying , Seymour Lorraine , Shamim Nimat , Shi Lili , Sivakumar Bhuvaneswari
Published: January 2022

The number of publications in electrochemical energy storage has increased exponentially in the past decades, focusing mostly on materials science. The electrochemical process controlling the observed overall performances is often not well discussed. This article highlights the importance of understanding rate-limiting steps in the electrochemical process which change dynamically at different conditions and scales. Applying electrochemistry to identify and overcome those rate-limiting steps in the electrochemical devices is the prerequisite to discovering effective solutions and designing different batteries to further advance electrochemical energy storage systems for a broad range of various applications.
Mechanistic Analysis of Hydrogen Evolution and Absorption Reactions on Iron
Authors: Abd Elhamid M. H.
Published: January 2022

A Summary Report to The Electrochemical Society for a 1998 Department of Energy Summer Research Fellowship.
Design and Practice of Aerobics Teaching Design Based on Data Fusion Algorithm
Authors: Ma Chuanqi
Published: January 2022

Aerobic exercise is a very popular form of exercise. It combines various forms of sports and music. Aerobic exercise improves muscle tone and relaxes the mind and body while burning calories. It is designed to individualize instruction for different audiences. It is an important factor in the applicability of the operation. The purpose of this paper is to build different human models based on sensor network numbers to quantify different movements through the Internet of Things (IoT) to design personalized curriculum design and practice to improve the popularity of creative aerobics curriculum. In this paper, we first give an overview of the algorithm and data fusion algorithm and then simulate the aerobics creative curriculum design. First, the variance is used as the error measure to establish the data fusion algorithm and aerobics new concept innovation curriculum design and practice. The established model is compared with the aerobics curriculum design under the traditional model to highlight the advantages of the curriculum design under the data fusion algorithm. A comparison is also made with examples. The experimental results show that the data of the audience’s movement changes during different creative processes solve the aerobics creative editing problem. Compared with the traditional curriculum design, the efficiency of the curriculum design and practice is improved by 20.23%.
[Retracted] Construction and Simulation of Online English Reading Model in Wireless Surface Acoustic Wave Sensor Environment Optimized by Particle Swarm Optimization
Authors: Zhou Bolan
Published: January 2022

English reading is an important way to consolidate and expand English language knowledge, and it is also an important way to obtain information and understand British and American culture. Therefore, reading teaching has always been an important part of English education and teaching at all levels and types of schools, and college English teaching is no exception. College English teachers have been carrying out teaching reflections in their reading teaching practice and constantly exploring teaching modes and teaching directions that improve students’ reading engagement and reading comprehension ability. However, the current daily teaching of English reading still generally maintains the traditional teaching mode. The entire reading learning process is monotonous, boring, and stylized, and the ability to acquire and process information cannot be combined with language knowledge and language skills. This kind of teaching mode severely inhibited the college students’ involvement in English learning model. Based on the electromagnetic‐polarization response expression in a uniformly polarized half‐space, this paper transforms the problem of polarization parameter extraction into a minimum optimization problem and constructs a fitness function. A set of polarization parameters is selected to calculate the electromagnetic‐polarization response under trapezoidal waves in a uniform half‐space, and the basic particle swarm algorithm is used to extract single and multiple parameters, respectively. In this paper, by adding a window to the test data in the time domain, the multiplicative and additive interference in the test signal is suppressed, and the signal‐to‐noise ratio of the test result is improved. We use the platform built in this article to wirelessly test the temperature characteristics of the surface acoustic wave sensor. The research results identified eight cognitive attributes of English reading and successfully generated diagnostic information at the group and individual levels and finally formed graphics and textual diagnostic feedback. There is a certain correlation between students’ vocabulary mastery and English reading performance, which shows that the vocabulary teaching method can help students better understand the reading materials and improve their reading performance. Combining two student interviews and learning logs, it can be seen that students’ understanding and frequency of use of vocabulary knowledge have increased significantly after the action research. It is generally recognized that vocabulary has a positive effect on improving reading level and can be based on the recognition and understanding of vocabulary. The mastery of vocabulary can promote the improvement of college students’ English reading level to a certain extent. Learners should strengthen vocabulary learning and face up to the importance of vocabulary knowledge in English reading.
Concurrent Hearing and Genetic Screening among Newborns in Ningbo, China
Authors: Guomei Cao , Luyan Zhang , Lingling Dai , Chunhong Huang , Shan Chen
Published: January 2022

Objective. To detect the carrier rates of deafness gene variants in populations in Ningbo and analyze the risk of hereditary hearing loss through concurrent hearing and genetic screening tests. Methods. Two thousand one hundred and seventy-four newborns were enrolled from November 2018 to August 2019. All subjects underwent hearing screening and newborn deafness genetic screening with 15 variants in 4 genes, and the positive sites were simultaneously verified by sequencing. Results. The total carrier rate of genetic variants in Ningbo reached 4.32%, when GJB2 c.235delC was the variant with the highest prevalence (2.12%), approximately accounting for 48.9% of the total carrier frequency. The carrier frequency of SLC26A4 c.919-2A>G was 0.87%, while the most common variant in mitochondrial DNA (mtDNA) MT-RNR1 gene was m.1555A>G, and its carrier frequency was 0.184%. In the OAE testing, 92 newborns passing hearing screening were tested positively for variants in 4 genes, and 2 of 42 newborns who failed in the first hearing test were found to mutate in 4 genes. Conclusion. Herein, the results concerning the carrier rates for deafness gene mutations of Ningbo population are reported. Our study is beneficial to the insight into the deafness genomic epidemiology for deafness genes in Ningbo population and provides the reference for healthcare in Ningbo.
lncRNA GAS5 Sensitizes Breast Cancer Cells to Ionizing Radiation by Inhibiting DNA Repair
Authors: Ma Yan , Yu Lei , Yan Wenxing , Qiu Ling , Zhang Jianqiu , Jia Xiaojing
Published: January 2022

Radioresistance of breast cancer is a major reason for therapeutic failure and limits further increases in the dose of radiation due to severe adverse effects. Recently, long noncoding RNAs (lncRNAs) have been shown to regulate cancer proliferation, chemoresistance, and radioresistance. Among these lncRNAs, lncRNA GAS5 expression was shown to be downregulated in breast cancer and related to trastuzumab resistance. However, its role in the radiation response is unclear. In this study, we demonstrated that lncRNA GAS5 expression was reduced in irradiated cells and that overexpression of GAS5 reduced cell viability and promoted cell apoptosis after irradiation. Moreover, overexpression of GAS5 resulted in increased G2/M arrest and unrepaired DNA damage, indicating a radiosensitizing role of GAS5 in breast cancer cells. Finally, we found that a GAS5‐interacting miRNA, miR‐21, reversed the radiosensitizing effects of GAS5 by inhibiting the apoptotic pathway. In conclusion, we found that lncRNA GAS5 sensitized breast cancer cells to ionizing radiation by inhibiting DNA repair and suppressing miR‐21, identifying novel targets for breast cancer radiosensitization.
The System Research of the Molecular Mechanism of Quyushengxin Capsule in the Treatment of Osteonecrosis of the Femoral Head
Authors: Du Xia , Zhao Lintao , Qiao Yuan , Liu Yuan , Guo Dong
Published: January 2022

Osteonecrosis of the femoral head (ONFH) is a chronic and irreversible disease that has a risk of eventually developing into a joint collapse and resulting in joint dysfunction. Quyushengxin capsule (QYSXC) is an effective and safe traditional Chinese medicine used in the treatment of ONFH. In this present study, an integrated approach was used to investigate the mechanism of QYSXC in the treatment of ONFH, which contained systems pharmacology, molecular docking, and chip experiment. In the systems pharmacology, target fishing, protein-protein interaction (PPI), Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis, and herbs-compounds-targets-pathways (H-C-T-P) network construction were performed to study the mechanism of QYSXC in the treatment of ONFH. The results showed that 15 key compounds, 8 key targets, and 8 key signaling pathways were found for QYSXC in the treatment with ONFH. Then, molecular docking was performed to further explore the interaction between some key compounds and key targets. After that, the chip experiment was performed to verify some target factors, including ICAM-1, IL-6, IL-1α, IL-1β, IL-2, IL-4, IL-10, and TNF-α. The results of this work may provide a theoretical basis for further research on the molecular mechanism of QYSXC in the treatment of ONFH.
Signature Construction and Molecular Subtype Identification Based on Pyroptosis-Related Genes for Better Prediction of Prognosis in Hepatocellular Carcinoma
Authors: Chen Ji , Tao Qiqi , Lang Zhichao , Gao Yuxiang , Jin Yan , Li Xiaoqi , Wang Yajing , Zhang Yuxiao , Yu Suhui , Lv Boyu , Yu Zhengping , Lin Changyong
Published: January 2022

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. However, there is a lack of adequate means of treatment prognostication for HCC. Pyroptosis is a newly discovered way of programmed cell death. However, the prognostic role of pyroptosis in HCC has not been thoroughly investigated. Here, we generated a novel prognostic signature to evaluate the prognostic value of pyroptosis-related genes (PRGs) using the data from The Cancer Genome Atlas (TCGA) database. The accuracy of the signature was validated using survival analysis through the International Cancer Genome Consortium cohort (

n
=
231

) and the First Affiliated Hospital of Wenzhou Medical University cohort (

n
=
180

). Compared with other clinical factors, the risk score of the signature was found to be associated with better patient outcomes. The enrichment analysis identified multiple pathways related with pyroptosis in HCC. Furthermore, drug sensitivity testing identified six potential chemotherapeutic agents to provide possible treatment avenues. Interestingly, patients with low risk were confirmed to be associated with lower tumor mutation burden (TMB). However, patients at high risk were found to have a higher count of immune cells. Consensus clustering was performed to identify two main molecular subtypes (named clusters A and B) based on the signature. It was found that compared with cluster B, better survival outcomes and lower TMB were observed in cluster A. In conclusion, signature construction and molecular subtype identification of PRGs could be used to predict the prognosis of HCC, which may provide a specific reference for the development of novel biomarkers for HCC treatment.
Study on Strengthening Mechanism of Epoxy Resin/Rubber Concrete Interface by Molecular Dynamics Simulation
Authors: Li Lijuan , Qin Dajing , Xu Zhijun , Feng Yong
Published: January 2022

Rubber concrete has high environmental and economic benefits. However, the difference in the physical and chemical properties of the interface causes a weak interface between rubber and concrete, which limits the use of rubber concrete to a certain extent. Based on the macroexperiment of epoxy resin (EP) modified rubber concrete, from the nanoscale level, three interface models of Rh (natural rubber)/C‐S‐H, EP/C‐S‐H, and Rh/EP/C‐S‐H were constructed by molecular dynamics simulation to explore the interaction between epoxy resin and rubber cement‐based interface and reveal its microreinforcement mechanism. The results of interaction energy, radial distribution function, and mean square displacement show that the addition of EP not only improves the interface interaction energy between Rh and C‐S‐H but also provides a large number of hydrogen bond donors and receptors, promotes the diffusion of Ca, and increases the adhesion between Rh and cement matrix. The results of the analysis of mechanical properties show that the elastic modulus of the rubber concrete interface model is improved and the interface properties are improved after adding EP.
Practice and Discussion on the Management Mode of Comprehensive Pharmacy under the Strategy of Healthy China
Authors: Liao Jing , Hua Xiaoli , Cai Xuefeng , Su Yuyong , Yu Lixiu
Published: January 2022

Objective. To explore the practice of comprehensive pharmacy management mode under the strategy of healthy China. Methods. Combining with hospital practice, the advantages and disadvantages of comprehensive pharmacy management mode were discussed and considered. Results. The comprehensive pharmacy has advantages in improving work efficiency, optimizing resource allocation, refining pharmacy management, checking the compatibility of Chinese and Western medicines, and improving service quality, and it also increases the labor intensity of staff and is prone to prescription dispensing errors. Conclusion. Hospitals with mature conditions and permission can use the management mode of comprehensive pharmacy.
Design and Implementation of Intelligent Vehicle Control System Based on Internet of Things and Intelligent Transportation
Authors: Hu Zhihui , Tang Hai
Published: January 2022

With the improvement of urbanization and the continuous expansion of transportation scale, traffic problem has become an important problem in our life. How to ensure traffic safety has become the key issue for the government to implement social management. Nowadays, Internet of Things (IOT) technology is widely used in the industrial technology field. It will have a great impact on human production and life. Intelligent transportation system is a research field involving many high and new technologies. This paper proposes an intelligent transportation system based on Internet of Things technology. This paper presents the optimal design structure of intelligent transportation system based on Internet of Things technology. The experimental results show that the intelligent transportation system can effectively realize the information interaction between the vehicle and the control center and understand the road conditions in advance. At the same time, the intelligent transportation system can improve the driving speed of vehicles on the road, make effective use of resources, reduce economic losses during vehicle operation, and reduce air pollution caused by gasoline emission.
Preparation of Drug Sustained-Release Scaffold with De-Epithelized Human Amniotic Epithelial Cells and Thiolated Chitosan Nanocarriers and Its Repair Effect on Spinal Cord Injury
Authors: Zhu Lijuan , Tian Shaohua , Li Zhiyong , Fan Dandan , Gao Hongwei , Zhang Hongyu , Bao Zhengqing , Zhang Wenlong
Published: January 2022

The disability rate of spinal cord injury (SCI) is extremely high, and stem cell inhibition is one of the most effective schemes in treating the spinal cord, but the survival rate is extremely low after stem cell transplantation, so it cannot be widely used in clinic. Studies have revealed that loading stem cells with biological scaffolds can effectively improve the survival rate and effect after stem cell transplantation. Therefore, this research was devised to analyze the repair effect of thiolated chitosan nanocarriers scaffold carrying de-epithelized human amniotic epithelial cells (HAECs) on SCI. And we used thiolated chitosan as nanocarriers, aiming to provide a reliable theoretical basis for future clinical practice. Through experiments, we concluded that the Tarlov and BBB scores of rats with SCI were raised under the intervention of thiolated chitosan carrying HAECs, while the inflammatory factors in serum, oxidative stress reaction in spinal cord tissue, apoptosis rate of nerve cells, and autophagy protein expression were all suppressed. Thus, the thiolated chitosan carrying HAECs may be applied to treat SCI by suppressing autophagy protein expression, oxidative stress response, and release of inflammatory factors in spinal cord tissue, which may be a new clinical therapy for SCI in the future. Even though we cannot understand exactly the therapeutic mechanism of thiolated chitosan carrying HAECs for SCI, the real clinical application of thiolated chitosan carrying HAECs needs to be confirmed by human experiments.
PACAM: A Pairwise-Allocated Strategy and Capability Average Matrix-Based Task Scheduling Approach for Edge Computing
Authors: Hong Feng , Zhang Tianming , Cao Bin , Fan Jing
Published: January 2022

With the development of the smart Internet of Things (IoT), an increasing number of tasks are deployed on the edge of the network. Considering the substantially limited processing capability of IoT devices, task scheduling as an effective solution offers low latency and flexible computation to improve the system performance and increase the quality of services. However, limited computing resources make it challenging to assign the right tasks to the right devices at the edge of the network. To this end, we propose a polynomial-time solution, which consists of three steps, i.e., identifying available devices, estimating device quantity, and searching for feasible schedules. In order to shrink the number of potential schedules, we present a pairwise-allocated strategy (PA). Based on these, a capability average matrix (CAM)-based index is designed to further boost efficiency. In addition, we evaluate the schedules by the technique for order preference by similarity to an ideal solution (TOPSIS). Extensive experimental evaluation using both real and synthetic datasets demonstrates the efficiency and effectiveness of our proposed approach.