bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Flexible Friction Nanogenerator and Sensor in Sports Safety Monitoring
Authors: Liu Erwei
Published: September 2022

With the development of science and technology, nanotechnology gradually becomes the growing energy shortage of new energy technology, and gains more and more scientists’ attention. Friction nanogenerator (TENG) is a nanogenerator with efficient energy conversion. Nanotextile (TEF-F) is a kind of friction material suitable for human skin, because nanotextiles have antibacterial function, radiation prevention, antistatic resistance, flame retardant, and other functions, and they can act on the outer layer of the skin and play a very good protective role. This article aims at studying a flexible friction nanogenerator and sensor as a safety monitoring equipment for sports. In this article, PTFE and nylon are proposed as friction nanomaterials of a flexible friction nanogenerator. A model of power generation by friction between insole and athlete is designed and tested. The experimental results show that the output voltage of PTFE friction nanomaterials with 50% water tightness can reach 200 V. Under the same conditions, compared with the output voltage of different textile fibers, the output voltage of nylon is up to 180 V. The output voltage of thin PTFE can reach 200 V, while that of nylon can reach 180 V. The output voltage of PTFE with medium thickness is 65 V, while that of nylon is 84 V. For thicker PTFE, the output voltage is only 58 V, while that of nylon is only 67 V. Therefore, for cotton, polyester, and nylon under the same conditions, the output voltage of nylon is significantly higher than that of different textile fibers. Moreover, for PTFE and nylon friction nanomaterials, the thinner their thickness, the higher their output voltage is.
Equalization Optimizer-Based LSTM Application in Reservoir Identification
Authors: Yang Fan , Xia Kewen , Fan Shurui , Zhang Zhiwei
Published: September 2022

In recent years, the use of long short-term memory (LSTM) has made significant contributions to various fields and the use of intelligent optimization algorithms combined with LSTM is also one of the best ways to improve model shortcomings and increase classification accuracy. Reservoir identification is a key and difficult point in the process of logging, so using LSTM to identify the reservoir is very important. To improve the logging reservoir identification accuracy of LSTM, an improved equalization optimizer algorithm (TAFEO) is proposed in this paper to optimize the number of neurons and various parameters of LSTM. The TAFEO algorithm mainly employs tent chaotic mapping to enhance the population diversity of the algorithm, convergence factor is introduced to better balance the local and global search, and then, a premature disturbance strategy is employed to overcome the shortcomings of local minima. The optimization performance of the TAFEO algorithm is tested with 16 benchmark test functions and Wilcoxon rank-sum test for optimization results. The improved algorithm is superior to many intelligent optimization algorithms in accuracy and convergence speed and has good robustness. The receiver operating characteristic (ROC) curve is used to evaluate the performance of the optimized LSTM model. Through the simulation and comparison of UCI datasets, the results show that the performance of the LSTM model based on TAFEO has been significantly improved, and the maximum area under the ROC curve value can get 99.43%. In practical logging applications, LSTM based on an equalization optimizer is effective in well-logging reservoir identification, the highest recognition accuracy can get 95.01%, and the accuracy of reservoir identification is better than other existing identification methods.
Spleen and Liver Stiffness Evaluation by ARFI Imaging: A Reliable Tool for a Short-Term Monitoring of Portal Hypertension?
Authors: Binzberger Andreas , Hänle Mark , Pfahler Matthias , Kratzer Wolfgang , Seufferlein Thomas , Zizer Eugen
Published: September 2022

Background. Assessment of hepatic venous pressure gradient (HVPG) is the most reliable, though invasive method for evaluation of portal hypertension. Non-invasive, elastography-based techniques are well established in diagnosis, but not in monitoring of portal hypertension. The aim of our prospective study was to determine the value of acoustic radiation force impulse (ARFI) elastography technique of the liver and spleen in diagnosis and monitoring of portal hypertension. Methods. We prospectively assessed portal hypertension by HVPG and corresponding elastography of the liver and spleen in 31 patients with liver cirrhosis and an indication for primary prophylaxis by non-cardio selective beta-blockers. Investigations were performed at baseline and a follow-up visit after 6-8 weeks. To address the known large variability of values for spleen elastography, well-defined corresponding areas in the spleen were used for baseline and follow-up elastography. Sensitivity, specificity, and AUC-ROC values for both spleen and liver elastography monitoring of portal hypertension were calculated. Results. Liver but not spleen elastography significantly correlated with HVPG results and was suitable for initial evaluation of portal hypertension. However, changes in HVPG results did not show any correlation with alterations of ARFI values from baseline to follow-up visits both for liver and spleen elastography. Spleen stiffness results were not homogeneous across the whole organ differing significantly between the upper, hilar, and bottom placed investigation areas. Conclusions. In this prospective study ARFI-based assessment of liver elastography showed itself suitable for initial assessment but not for monitoring of portal hypertension. Spleen elastography was not appropriate for both, evaluation and monitoring of portal hypertension. A possible explanation for this new data that are in some contrast to previously published results is the degree of portal hypertension in our study, a comparatively short follow-up period, and well-defined investigation areas for spleen elastography in repetitive ARFI investigations. This trial is registered with NCT03315767.
Application of Virtual Reality Technology in Art Design: A Systematic Approach
Authors: Ma Xin
Published: September 2022

The 21st century witnesses innovative concepts in the field of technology and multimedia integrated with networking. The new concept is referred to as Virtual Reality, which is a combination of multimedia and networking. Virtual Reality is wholly different from other advanced technologies that are visually appealing. The main features of virtual reality are identified as spatial conception, perception comprehensiveness, and information interaction. Apart from the above, other specialties of virtual reality are the generation of 3D images and presenting information in a unique way. These features are generally applied across different fields, such as environmental design, architecture, public art design, and other industries. Virtual Reality processes the precise data calculation and then optimises the display experience of the users/customer. It also fulfills customers’ needs and enhances user satisfaction by exchanging valuable information. The entire gaming industry applies Virtual Reality, and thus, the world looks more mature. Even the tourism industry has started using Virtual Reality which has the potential to bring novel experiences and vitality to the audience. Therefore, it can be confirmed that the application of Virtual Reality will undergo continuous development and advancement, adjusting to the needs of the industries. The primary aim of this study is to gain an in-depth understanding of the Virtual Reality concept and the application of Virtual Reality in art design and to examine the impact of Virtual Reality on public art design. This article also reviews the features of Virtual Reality and its application in art designs. The advantages of Virtual Reality will also be discussed broadly. At last, this study proposes a feasibility model of Virtual Reality that can be applied in public art design.
Privacy Law Protection Based on the Information Security Assurance Algorithm
Authors: Wang Zhanjiang , Yue Qifeng
Published: September 2022

With the continuous development of network technology, the production and lifestyle of human beings are also quietly changing. People find that the network makes life faster and more convenient and also makes our life more “transparent.” The openness, sharing, and convenience of the network make it easier to infringe on the privacy rights of others, bringing an unprecedented impact on traditional privacy protection. This paper studied information security assurance-related algorithms and built an information security assurance model. Through this model, some privacy violation events existing in the network today were analyzed. Then, a corresponding questionnaire was constructed according to some of the problems of these events. The questionnaire is mainly used for research on people of all age groups, mainly to study their understanding of relevant legal knowledge and their views on the law. A total of 188 valid questionnaires were collected in this survey. Only 37.23% people knew a lot about the law. Most of them learned it from the Internet, and they rarely learned about it from relevant books. About 70% people believe that the law plays a big role in privacy protection, and they will choose legal help if they encounter privacy violations. However, this is inconsistent with some data obtained from the information security assurance model. Through analysis, it can be seen that although they want legal help, they lack the relevant knowledge of the law, and they do not know whether the privacy of individuals has been violated. Therefore, it is necessary to strengthen personal knowledge of privacy protection laws and improve the personal information legal protection and fair use system.
Effect of Loading Rates on Mechanical Characteristics and Rock Burst Tendency of Coal-Rock Combined Samples
Authors: Hu Jiang , Li Jingang
Published: September 2022

According to the universal law of thermodynamics, the failure of any substance is closely related to its energy change. Understanding the strain energy and rock burst tendency of rock or coal under different loading rates is critical in many geological projects, such as mining, tunneling, and other underground engineering project. The mechanical and energy evolution characteristics of the coal-rock combined sample under different loading rates of uniaxial compression were numerically investigated. And, the rock burst tendency was also calculated by the Rock Burst Energy Index KE. The results show that with the increase of the loading rate, the total input energy, elastic strain energy, and dissipation energy all show an increasing trend. But the growth trend is different. And, under the five loading rates, the Rock Burst Energy Index KE of the coal-rock combined sample were all between 1.5 ≤ KE < 5. That is, they all have weak rock burst tendency. And the rock burst energy index increases first and then decreases with the increase of loading rates. This study provides references for propulsion speed of working face in the field mining practice.
Possible Involvement of DNA Methylation in TSC1 Gene Expression in Neuroprotection Induced by Hypoxic Preconditioning
Authors: Qi Ruifang , Xie Yabin , Zhang Xiaolu , Jiang Shuyuan , Liu Xiaolei , Xie Wei , Jia Xiaoe , Bade Rengui , Liu You , Gong Kerui , Yang Wenjie , Guo Guanghui , Sun Kai , Zhang Chunyang , Han Ruijuan , Shao Guo
Published: September 2022

Background. It has been reported that ischemia and ischemic preconditioning (IPC) have different effects on the expression of tuberous sclerosis complex 1 (TSC1), which may contribute to the tolerance to ischemia/hypoxia with the increase of autophagy. The mechanisms of TSC1 differential expression are still unclear under ischemia/IPC conditions in hippocampal Cornu Ammon 1 (CA1) and Cornu Ammon 3 (CA3) area neuronal cells. While we have shown that 5-Aza-CdR, a DNA methyltransferase inhibitor, can upregulate TSC1 and increase hypoxic tolerance by autophagy in vivo and in vitro, in this study, we examined whether DNA methylation was involved in the differential expression of TSC1 in the CA1 and CA3 regions induced by hypoxic preconditioning (HPC). Methods. Level of rapamycin (mTOR) autophagy, a downstream molecular pathway of TSC1/TSC2 complex, was detected in HPC mouse hippocampal CA1 and CA3 areas as well as in the HPC model of mouse hippocampal HT22 cells. DNA methylation level of TSC1 promoter (-720 bp~ -360 bp) was determined in CA1 and CA3 areas by bisulfite-modified DNA sequencing (BMDS). At the same time, autophagy was detected in HT22 cells transfected with GFP-LC3 plasmid. The role of TSC1 in neuroprotection was measured by cell viability and apoptosis, and the role of TSC1 in metabolism was checked by ATP assay and ROS assay in HT22 cells that overexpressed/knocked down TSC1. Results. HPC upregulated the expression of TSC1, downregulated the level of P-mTOR (Ser2448) and P-p70S6K (Thr389), and enhanced the activity of autophagy in both in vivo and in vitro. The increased expression of TSC1 in HPC may depend on its DNA hypomethylation in the promoter region in vivo. HPC also could reduce energy consumption in HT22 cells. Overexpression and knockdown of TSC1 can affect cell viability, cell apoptosis, and metabolism in HT22 cells exposed to hypoxia. Conclusion. TSC1 expression induced by HPC may relate to the downregulation of its DNA methylation level with the increase of autophagy and the decrease of energy demand.
A Deep Neural Network Ensemble Classifier with Focal Loss for Automatic Arrhythmia Classification
Authors: Wu Han , Zhang Senhao , Bao Benkun , Li Jiuqiang , Zhang Yingying , Qiu Donghai , Yang Hongbo
Published: September 2022

Automated electrocardiogram classification techniques play an important role in assisting physicians in diagnosing arrhythmia. Among these, the automatic classification of single-lead heartbeats has received wider attention due to the urgent need for portable ECG monitoring devices. Although many heartbeat classification studies performed well in intrapatient assessment, they do not perform as well in interpatient assessment. In particular, for supraventricular ectopic heartbeats (S), most models do not classify them well. To solve these challenges, this article provides an automated arrhythmia classification algorithm. There are three key components of the algorithm. First, a new heartbeat segmentation method is used, which improves the algorithm’s capacity to classify S substantially. Second, to overcome the problems created by data imbalance, a combination of traditional sampling and focal loss is applied. Finally, using the interpatient evaluation paradigm, a deep convolutional neural network ensemble classifier is built to perform classification validation. The experimental results show that the overall accuracy of the method is 91.89%, the sensitivity is 85.37%, the positive productivity is 59.51%, and the specificity is 93.15%. In particular, for the supraventricular ectopic heartbeat(s), the method achieved a sensitivity of 80.23%, a positivity of 49.40%, and a specificity of 96.85%, exceeding most existing studies. Even without any manually extracted features or heartbeat preprocessing, the technique achieved high classification performance in the interpatient assessment paradigm.
Cross-Modal Discrimination Hashing Retrieval Using Variable Length
Authors: He Chao , Wang Dalin , Tan Zefu , Xu Liming , Dai Nina
Published: September 2022

Fast cross-modal retrieval technology based on hash coding has become a hot topic for the rich multimodal data (text, image, audio, etc.), especially security and privacy challenges in the Internet of Things and mobile edge computing. However, most methods based on hash coding are only mapped to the common hash coding space, and it relaxes the two value constraints of hash coding. Therefore, the learning of the multimodal hash coding may not be sufficient and effective to express the original multimodal data and cause the hash encoding category to be less discriminatory. For the sake of solving these problems, this paper proposes a method of mapping each modal data to the optimal length of hash coding space, respectively, and then the hash encoding of each modal data is solved by the discrete cross-modal hash algorithm of two value constraints. Finally, the similarity of multimodal data is compared in the potential space. The experimental results of the cross-model retrieval based on variable hash coding are better than that of the relative comparison methods in the WIKI data set, NUS-WIDE data set, as well as MIRFlickr data set, and the method we proposed is proved to be feasible and effective.
Design of Three-Dimensional Pleated Clothing Pattern Based on Computer Animation Technology
Authors: Sun Wenbo , Guo Dugang
Published: September 2022

With the improvement of people's living standards, people's pursuit of clothing is becoming more and more diverse. As the main way to shape the external curve of the human body and reflect the texture of clothing materials, pleating technology is widely used in clothing. Different wrinkle expression techniques can often be seen in garment production and press conferences. Many designers are inseparable from the use of folding technology in their creation. The decoration of clothing is also constantly enriched. Diversified and multitype fabrics will bring great differences and influence to clothing and even affect the trend. Based on the computer animation technology, through the analysis of the principle of three-dimensional folds, this paper explores the formation of geometric patterns from two-dimensional plane fabric laying to three-dimensional, mainly through the techniques of pleating, kneading, lattice pleating, and pleating, so as to knead, stack or stack the fabrics orderly or randomly and naturally. The folded intersection area and nonfolded area are formed to form the basis of three-dimensional geometric folds. The simulation results show that the computer animation technology can effectively support the three-dimensional fold garment pattern design, select different materials for regional folding, present obvious three-dimensional geometric pattern folds, understand the expression forms of folds, and explain the application of folds in garment design, so as to provide some reference for fold garment design.
An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Authors: Sheinboim Danna , Parikh Shivang , Manich Paulee , Markus Irit , Dahan Sapir , Parikh Roma , Stubbs Elisa , Cohen Gali , Zemser-Werner Valentina , Bell Rachel E. , Ruiz Sara Arciniegas , Percik Ruth , Brenner Ronen , Leibou Stav , Vaknine Hananya , Arad Gali , Gerber Yariv , Keinan-Boker Lital , Shimony Tal , Bikovski Lior , Goldstein Nir , Constantini Keren , Labes Sapir , Mordechai Shimonov , Doron Hila , Lonescu Ariel , Ziv Tamar , Nizri Eran , Choshen Guy , Eldar-Finkelman Hagit , Tabach Yuval , Helman Aharon , Ben-Eliyahu Shamgar , Erez Neta , Perlson Eran , Geiger Tamar , Ben-Zvi Danny , Khaled Mehdi , Gepner Yftach , Levy Carmit
Published: September 2022

Exercise prevents cancer incidence and recurrence, yet the underlying mechanism behind this relationship remains mostly unknown. Here we report that exercise induces the metabolic reprogramming of internal organs that increases nutrient demand and protects against metastatic colonization by limiting nutrient availability to the tumor, generating an exercise-induced metabolic shield. Proteomic and ex vivo metabolic capacity analyses of murine internal organs revealed that exercise induces catabolic processes, glucose uptake, mitochondrial activity, and GLUT expression. Proteomic analysis of routinely active human subject plasma demonstrated increased carbohydrate utilization following exercise. Epidemiologic data from a 20-year prospective study of a large human cohort of initially cancer-free participants revealed that exercise prior to cancer initiation had a modest impact on cancer incidence in low metastatic stages but significantly reduced the likelihood of highly metastatic cancer. In three models of melanoma in mice, exercise prior to cancer injection significantly protected against metastases in distant organs. The protective effects of exercise were dependent on mTOR activity, and inhibition of the mTOR pathway with rapamycin treatment ex vivo reversed the exercise-induced metabolic shield. Under limited glucose conditions, active stroma consumed significantly more glucose at the expense of the tumor. Collectively, these data suggest a clash between the metabolic plasticity of cancer and exercise-induced metabolic reprogramming of the stroma, raising an opportunity to block metastasis by challenging the metabolic needs of the tumor.

Significance:

Exercise protects against cancer progression and metastasis by inducing a high nutrient demand in internal organs, indicating that reducing nutrient availability to tumor cells represents a potential strategy to prevent metastasis.

See related commentary by Zerhouni and Piskounova, p. 4124
Facts and Hopes on the Use of Artificial Intelligence for Predictive Immunotherapy Biomarkers in Cancer
Authors: Ghaffari Laleh Narmin , Ligero Marta , Perez-Lopez Raquel , Kather Jakob Nikolas
Published: September 2022

Immunotherapy by immune checkpoint inhibitors has become a standard treatment strategy for many types of solid tumors. However, the majority of patients with cancer will not respond, and predicting response to this therapy is still a challenge. Artificial intelligence (AI) methods can extract meaningful information from complex data, such as image data. In clinical routine, radiology or histopathology images are ubiquitously available. AI has been used to predict the response to immunotherapy from radiology or histopathology images, either directly or indirectly via surrogate markers. While none of these methods are currently used in clinical routine, academic and commercial developments are pointing toward potential clinical adoption in the near future. Here, we summarize the state of the art in AI-based image biomarkers for immunotherapy response based on radiology and histopathology images. We point out limitations, caveats, and pitfalls, including biases, generalizability, and explainability, which are relevant for researchers and health care providers alike, and outline key clinical use cases of this new class of predictive biomarkers.
Development and Validation of a Noninvasive Risk Score Model for Liver Cirrhosis in At-Risk Alcohol Drinkers Without HBV/HCV Infection
Authors: Liu Yin , Guo Lan-Wei , Xu Hui-Fang , Kang Rui-Hua , Zheng Li-Yang , Zhang Lu-Yao , Chen Qiong , Sun Xi-Bin , Qiao You-Lin , Zhang Shao-Kai
Published: September 2022

At-risk alcohol consumption is the established most important risk factor for cirrhosis in people without HBV/HCV infection. We aimed to develop and validate a simple and non-invasive tool for triaging cirrhosis risk in at-risk alcohol drinkers without HBV/HCV infection. A large-sample size, cross-sectional study within the framework of a population-based Cancer Screening Program in Urban China (CanSPUC) was conducted. Data on the liver cancer screening in Henan province, China were used. At-risk alcohol drinkers were those who currently drink one or more alcohol units per week for at least six months. A total of 6,581 eligible participants enrolled from October 1, 2013 to December 31, 2016 were included into the derivation dataset, and 2,096 eligible participants enrolled from January 1, 2017 to October 31, 2018 were included into the external validation dataset, respectively. Using the derivation dataset, a 20-point scale risk score model was developed, based on sex, education background, dietary intake of vegetables, dietary intake of roughage, smoking index, length of secondhand smoke exposure, history of fatty liver, history of diabetes, and first-degree family history of liver cancer. The model showed excellent discrimination (AUC  =  0.787; 95% CI, 0.7603–0.812) and calibration (Hosmer–Lemeshow test: P = 0.123) in the derivation dataset and an optimal cut-off value of 12 yield sensitivity of 61.3%, specificity of 82.7%. The model also had achieved similar performance in the external validation dataset. In conclusion, this model can be a practical tool to identify and triage population at high risk of cirrhosis in at-risk alcohol drinkers without HBV/HCV infection.

Prevention Relevance:

The risk model we developed will not only be used as a practical tool to triage high risk groups for liver cirrhosis, but also have implications for public health measures, such as guidelines for the prevention of liver cancer, in at-risk alcohol drinkers without HBV/HCV infection.
Cancer Immunotherapies Based on Genetically Engineered Macrophages
Authors: Cannac Marion , Nikolic Jovan , Benaroch Philippe
Published: September 2022

Anticancer immunotherapies are therapeutics aimed at eliciting immune responses against tumor cells. Immunotherapies based on adoptive transfer of engineered immune cells have raised great hopes of cures because of the success of chimeric antigen receptor T-cell therapy in treating some hematologic malignancies. In parallel, advances in detailed analyses of the microenvironment of many solid tumors using high-dimensional approaches have established the origins and abundant presence of tumor-associated macrophages. These macrophages have an anti-inflammatory phenotype and promote tumor growth through a variety of mechanisms. Attempts have been made to engineer macrophages with chimeric receptors or transgenes to counteract their protumor activities and promote their antitumor functions such as phagocytosis of cancer cells, presentation of tumor antigens, and production of inflammatory cytokines. In this review, we cover current breakthroughs in engineering myeloid cells to combat cancer as well as potential prospects for myeloid-cell treatments.
Effects of Resveratrol on Hepatitis B Virus Replication: In vitro and in vivo Experiments
Authors: Pan Peipei , Li Jiaohui , Lin Wei , Long Guangyan
Published: September 2022

Introduction: Hepatitis B virus (HBV) infection is a disease with high incidence and lack of effective treatment. In this study, we further explored the mechanism of resveratrol (RVT) in the inhibition of HBV replication. The effects of RVT on HBV replication were verified using in vitro and in vivo experiments. Methods: HepG2 and HepG2.2.15 cell lines were cultured in vitro, and different concentrations of RVT were used to determine its effect on the proliferation of the two cell lines. Autophagy agonists and inhibitors were given, and whether RVT exerts its effect on the proliferation of HepG2 and HepG2.2.15 cells through autophagy was determined. Reverse transcription-quantitative polymerase chain reaction and Western blot were used to detect changes in autophagy-related factors LC3-II, LC3-I, Beclin 1, and p62. Through transfection of pmiR-155, shmiR-155, and the corresponding control group, the relevant mechanism of RVT in inhibiting the proliferation of HepG2 and HepG2.2.15 cells was analyzed. RVT inhibited the toxicity for HepG2.2.15 cells and reduced HBV replication in vitro (p < 0.05). This effect of RVT was enhanced by rapamycin (RAPA; autophagy activator; p < 0.05) but was partially reversed by 3-MA (autophagy inhibitor; p < 0.05). In addition, our results showed that miR-155 expression was higher in HepG2.2.15 cells than in HepG cells (p < 0.05). miR-155 expression in the RVT treatment group was significantly reduced (p < 0.05). We designed an miR-155 overexpression plasmid, low miR-155 expression plasmid, and the corresponding negative control for transfection and found that transfection of pmiR-155 can partially reverse the effect of RVT (p < 0.05), while transfection with shmiR-155 can enhance the effect of RVT (p < 0.05). Discussion: RVT inhibits miR-155, activates autophagy, inhibits the toxicity for HepG2.2.15 cells, and reduces HBV replication, providing a new research direction for the treatment of HBV infection.
Mantelzelllymphom: Die wirkungsvollste ist nicht immer die beste Therapie
Authors: Claus Rainer , Sommer Sebastian
Published: September 2022

Ibrutinib, ein Bruton-Tyrosinkinase-Inhibitor, kann bei älteren Patienten mit unbehandeltem Mantelzelllymphom einen klinischen Nutzen haben, wenn er in Kombination mit Bendamustin und Rituximab verabreicht wird, gefolgt von einer Rituximab-Erhaltungstherapie. Im Rahmen der SHINE Studie haben Patienten ab 65 Jahren nach dem Zufallsprinzip entweder Ibrutinib oder Placebo sowie 6 Zyklen von Bendamustin und Rituximab erhalten. Sprachen die Patienten auf die Therapie an (vollständiges oder teilweises Ansprechen), erhielten sie eine Erhaltungstherapie mit Rituximab, die alle 8 Wochen verabreicht wurde. Der primäre Endpunkt war das progressionsfreie Überleben. Auch das Gesamtüberleben und die Sicherheit wurden bewertet. Von den 523 Patienten wurden 261 nach dem Zufallsprinzip für die Behandlung mit Ibrutinib und 262 für die Behandlung mit Placebo ausgewählt. Bei einer medianen Nachbeobachtungszeit von 84,7 Monaten betrug die mediane progressionsfreie Überlebenszeit 80,6 Monate in der Ibrutinib-Gruppe und 52,9 Monate in der Placebo-Gruppe (Hazard Ratio für Krankheitsprogression oder Tod, 0,75; 95% Konfidenzintervall, 0,59 bis 0,96; P = 0,01). Der Prozentsatz der Patienten mit einem vollständigen Ansprechen betrug 65,5% in der Ibrutinib-Gruppe und 57,6% in der Placebo-Gruppe (P = 0,06). Das Gesamtüberleben war in beiden Gruppen ähnlich. Die Inzidenz von unerwünschten Ereignissen des Grades 3 oder 4 während der Behandlung betrug 81,5 % in der Ibrutinib-Gruppe und 77,3 % in der Placebo-Gruppe.
Fracassos na aquisição: os cantos da fala na relação corpo e linguagem
Authors: Oliveira Mariana Trenche de
Published: September 2022

Este trabalho parte de inquietações acerca do atendimento de uma criança, na Clínica de Linguagem, cuja mãe solicitou um diagnóstico diferencial entre Apraxia de Fala na Infância e Transtorno do Espectro Autista. Discute-se a contradição entre a indecidibilidade diagnóstica e a suposta universalidade destas categorias. O objetivo é propor um diagnóstico de linguagem que leve em consideração não somente as inusitadas produções orais de uma criança, mas seu modo de relação à fala do outro e à própria. Utilizou-se como método a discussão de um caso clínico, cujo diagnóstico de linguagem era indicativo de fracassos na inscrição significante no corpo. A intervenção foi realizada sobre o efeito da fala da criança no outro que, à deriva, ficava preso ao espelhamento do gesto motor, impossibilitado de a ele atribuir valor linguístico.
Não é somente sobre Kevin que precisamos falar
Authors: Gomes Andréa Kioko Sonoda , Martinez Viviana Carola Velasco
Published: September 2022

O objetivo deste estudo consiste em apresentar uma análise do filme Precisamos falar sobre Kevin, partindo das reflexões teóricas de Jean Laplanche sobre a teoria da sedução generalizada. O artigo apresenta as contribuições teóricas do autor e de seus seguidores, principalmente no que diz respeito às mensagens enigmáticas e à construção de um modelo tópico e unificado do aparelho psíquico. A análise do filme permitiu chamar a atenção para os efeitos das vicissitudes da sedução, explorando as especificidades presentes na comunicação entre o adulto e a criança que repercutem sobre as possibilidades de tradução das mensagens enigmáticas e seus efeitos na constituição do psiquismo. Verifica-se a fecundidade do aporte teórico na compreensão do trauma psíquico infantil, uma vez que as consequências deste encontro assimétrico podem ser devastadoras e desorganizadoras, conforme elucidado pela história de Kevin.
Melancolia e juventude num mundo sem perspectivas no ambiente onírico do filme "O professor substituto"
Authors: Garrido Caio , Imbrizi Jaquelina Maria
Published: September 2022

Dada a sobreposição de acontecimentos traumáticos a catástrofes anunciadas – tais como o colapso climático vindouro e os desmandos das autoridades que compõem a política e economia neoliberais – e a forma como esses acontecimentos reverberam no psiquismo dos jovens, o objetivo deste artigo é apresentar o filme O professor substituto de modo a tomá-lo como alegoria para a função traumatolítica dos sonhos e do cinema. Foi possível discutir uma das características da contemporaneidade, que favorece certa melancolização do laço social entre os jovens inseridos em uma sociedade distópica. Diante de tais acontecimentos, uma das evidências encontradas foi que a confiança dos sujeitos foi a mais penalizada, e por conta disso coube alargar a noção de esperança.
“Cada um é um”: constituição de saberes em uma experiência de formação na perspectiva inclusiva
Authors: Santos Felícia Maria Pereira dos , Rahme Mônica Maria Farid
Published: September 2022

Este artigo discute os resultados de uma pesquisa que investigou uma experiência de formação inicial na qual licenciandos de diferentes cursos de Graduação atuavam como mediadores de estudantes com deficiência em uma escola comum. A partir do conceito psicanalítico de saber, buscou-se compreender como se dá a mobilização de saberes pelos mediadores e quais efeitos emergiram para a sua formação profissional como professores. Por meio de rodas de conversa e entrevistas individuais, os depoimentos dos participantes apontaram saberes em construção no percurso de cada mediador, o que os possibilitava encontrar saídas para os impasses presentes na relação com o outro no contexto escolar. Os mediadores reconheceram a importância dessa vivência para a formação, elencaram aproximações e paradoxos na articulação teoria-prática, além de expressarem suas próprias elaborações acerca desta experiência.
Saber, inteligência e tradição: o educar e o educador em Chaui, Rancière e Lajonquière
Authors: Jesus Fabio Ferreira
Published: September 2022

O artigo parte da compreensão que Marilena Chaui, Jacques Rancière e Leandro de Lajonquière expressam sobre aspectos decisivos à relação professor-aluno. Particularmente no que dizem a respeito do ensino-aprendizagem. Com isso, explicitamos uma formulação subjacente ao que pensam esses autores acerca do ser professor. Referendamos suas posições ao identificarmos nelas uma relação entre saber, inteligência e tradição, a qual seja, os lugares que ocupam professor e aluno ante o conhecimento localizado em certa tradição discursiva na qual as personagens dessa trama estão inseridas. Um movimento de ideias tal que, no cotejo entre esses pensadores, culminou num exame sobre o mito tecnicizante e desenvolvimentista que tem norteado certas abordagens pedagógicas predominantes no Brasil, especialmente no que concernem ao ser professor.
Reconhecimento e redistribuição nas mídias digitais do Projeto Común Tierra
Authors: Curi Guilherme Oliveira , Ronsini Veneza Mayora
Published: September 2022

O artigo discute questões de reconhecimento, sustentabilidade e redistribuição a partir do monitoramento e análise das mídias digitais do projeto Común Tierra, empreitada itinerante originada a partir de uma viagem de seis anos pela América Latina com o objetivo de documentar comunidades sustentáveis e projetos ecológicos em diferentes países. Tomamos como base analítica a categoria de paridade participativa, partindo da hipótese de que as mídias do projeto podem ser consideradas processos comunicacionais comunitários responsáveis por divulgar pedagogicamente práticas ecológicas e promoverem um modo de vida sustentável como alternativa no sistema capitalista.
A participação como compromisso organizacional na TV pública
Authors: Seridório Daniele Ferreira , Rothberg Danilo , Pieranti Octavio Penna
Published: September 2022

A sustentabilidade das emissoras mantidas pelo poder público permanece incerta. Uma das formas de a sociedade intervir nesse cenário advém dos mecanismos de participação nas instâncias de gestão e produção editorial, o que poderia fortalecê-las ao ampliar a visibilidade de sua relevância para a cidadania e o atendimento do direito à comunicação e à informação. Este artigo verificou, por meio de análise documental, se a participação pública como princípio e prática foi ou não incorporada por emissoras públicas brasileiras como compromisso organizacional. Os resultados indicam escassa aderência à participação: somente quatro entre 23 emissoras efetivam-na institucionalmente, e ainda apenas de maneira parcial.
Micha Yosef Berdichevski e a vaca sagrada
Authors: Amâncio Moacir
Published: September 2022

A criação da literatura hebraica contemporânea teve origem no movimento iluminista judaico, a partir de fins do século 18, na Alemanha, desenvolvendo-se através do século seguinte e chegando à sua plena realização no decorrer do século 20, em Israel. Berdichevski foi um dos grandes pioneiros na criação do hebraico modernizado, que passou a dar expressão à problemática dos judeus na Europa oriental em seus diversos aspectos. O conto aqui traduzido é um exemplo do vigor da retomada de um idioma até então não falado, mas na clave da contemporaneidade.
As escolas pioneiras da terra de Israel e o resgate do hebraico como língua vernacular: afirmação e resistência do nacionalismo judaico
Authors: Cardoso Guilherme Aragão
Published: September 2022

A pesquisa investiga o encadeamento entre o ensino do hebraico moderno nas escolas pioneiras das colônias agrícolas da Terra de Israel e a afirmação e resistência do nacionalismo judaico ao final do século XIX. A expansão do conhecimento do hebraico e sua adoção como língua vernacular instauram processos políticos identitários que se divergem entre sionistas e hebraístas. O legado étnico-simbólico da língua hebraica desponta como núcleo do enraizamento cultural e institucional de nação, reforçando os aspectos de dominação e imposição linguística daqueles que defendem o hebraico moderno como instrumento de autoafirmação e autonomia. O percurso analítico compreende a dinâmica linguística como articuladora das relações sociais, da dominação e do poder simbólico, na esteira bourdiana. A resistência, como necessidade social, é evidenciada a partir de fontes historiográficas que arranjam o cenário no qual aponta os professores hebraístas como agentes sociais e políticos atuantes no engendramento de mecanismos culturais renovados.
Shiguionot (Fantasias), de Elisheva
Authors: Nesharim Flávia Fridman
Published: September 2022

Uma pioneira da literatura hebraica, poetisa, russa, cristã, que escreveu em hebraico, Elisheva trata em seu conto Shiguionot (Fantasias) sobre o confronto feminino interno entre o anseio por ser livre em nossas escolhas, em nosso agir e pensar, e a necessidade social do matrimônio e a consequente estabilização da mulher e do seu interior. Esse é o segundo conto traduzido, de uma série de três, com a temática mulheres pioneiras na literatura hebraica que escreveram sobre o feminismo no final do século XIX e início do século XX.
Half‐Dose (45 mg Twice Daily) Ticagrelor Versus Clopidogrel in Neuroendovascular Dual Antiplatelet Therapy: A Single‐Center Cohort Study
Authors: Mehta Tapan , Topiwala Karan , Masood Kamaran , Grande Andrew , Tummala Ramachandra , Jagadeesan Bharathi
Published: September 2022

Background

Cardiovascular literature has found aspirin‐based dual antiplatelet therapy using half‐dose ticagrelor (45 mg BID [T45]) to be superior to standard‐dose clopidogrel (75 mg once daily) in achieving lower P2Y12 reaction units without resulting in an increased incidence of intracranial hemorrhage. We present the first neuroendovascular experience based on T45 versus standard‐dose clopidogrel dual antiplatelet therapy in patients undergoing stent‐assist coiling/flow diversion as treatment for unruptured intracranial aneurysms.

Methods

This was a retrospective cohort study comparing patients receiving dual antiplatelet therapy with T45+aspirin 81 mg daily (group 1) with those receiving standard‐dose clopidogrel+aspirin 325 mg daily (group 2). The primary outcome was ischemic stroke occurring intraoperatively or within 48 hours postoperatively. The secondary outcomes were delayed ischemic stroke, intracranial hemorrhage, and 6‐month angiographic result.

Results

A total of 111 patients met the final inclusion criteria: group 1/T45 (37.8%, n=42) and group 2/standard‐dose clopidogrel (62.2%, n=69). The median (interquartile range) P2Y12 reaction units was significantly lower in group 1 (69; 37–124) versus group 2 (135; 75.5–175.5;
P
=0.027). However, there was no significant difference in the number of patients achieving therapeutic preprocedural P2Y12 reaction units (<194 at our institution's laboratory; 85.3% versus 81.2%;
P
=0.643). Primary outcome was comparable: group 1, 7.1% (n=3) versus group 2, 1.5% (n=1;
P
=0.149). All secondary outcomes were also comparable: delayed ischemic stroke (9.8% versus 4.4%;
P
=0.270), intracranial hemorrhage (4.1% versus 0%;
P
=0.129), access‐site bleeding requiring transfusion (0% versus 2.9%;
P
=0.526), and 6‐month Raymond–Roy score (
P
=0.642).

Conclusions

T45‐based dual antiplatelet therapy may be feasible in neuroendovascular interventions with comparable ischemic and hemorrhagic outcomes. This hypothesis needs to be further explored in larger prospective clinical trials.
Trois figures de l’adab ʿAbd al-Ḥamīd al-Kātib, Ibn al-Muqaffaʿ et al-Ǧāḥiẓ : une étude comparative
Authors: Natij Salah
Published: September 2022

In an approach which aims at reconstructing the concept of adab, we evoke in this study three figures of the thought of the adab (ʿAbdallah b. al-Muqaffaʿ m. 142/759, ʿAbd al-Ḥamīd al-Kātib m. 132/750 and Abū ʿUtman b. Baḥr al-Ǧāḥiz m. 255/868), by comparing their styles of thought and their intellectual attitudes at the same time in the field of the adab and in the political system of their times. Our objective is to show how each of three studied figures takes care of the thought of the adab and updates it. We speak about figures of the adab because we think that through these three personalities, the concept of adab is not only developed and expressed, but also acted, that is, brought to realization and actualization in different ways, depending on the sense of commitment of each of the three thinkers both intellectually and politically.
Diagnosing Scale-Dependent Energy Cycles in a High-Resolution Isopycnal Ocean Model
Authors: Loose Nora , Bachman Scott , Grooms Ian , Jansen Malte
Published: September 2022

Energy exchanges between large-scale ocean currents and mesoscale eddies play an important role in setting the large-scale ocean circulation but are not fully captured in models. To better understand and quantify the ocean energy cycle, we apply along-isopycnal spatial filtering to output from an isopycnal 1/32° primitive equation model with idealized Atlantic and Southern Ocean geometry and topography. We diagnose the energy cycle in two frameworks: 1) a non-thickness-weighted framework, resulting in a Lorenz-like energy cycle, and 2) a thickness-weighted framework, resulting in the Bleck energy cycle. This paper shows that framework 2 is more useful for studying energy pathways when an isopycnal average is used. Next, we investigate the Bleck cycle as a function of filter scale. Baroclinic conversion generates mesoscale eddy kinetic energy over a wide range of scales and peaks near the deformation scale at high latitudes but below the deformation scale at low latitudes. Away from topography, an inverse cascade transfers kinetic energy from the mesoscales to larger scales. The upscale energy transfer peaks near the energy-containing scale at high latitudes but below the deformation scale at low latitudes. Regions downstream of topography are characterized by a downscale kinetic energy transfer, in which mesoscale eddies are generated through barotropic instability. The scale- and flow-dependent energy pathways diagnosed in this paper provide a basis for evaluating and developing scale- and flow-aware mesoscale eddy parameterizations.

Significance Statement

Blowing winds provide a major energy source for the large-scale ocean circulation. A substantial fraction of this energy is converted to smaller-scale eddies, which swirl through the ocean as sea cyclones. Ocean turbulence causes these eddies to transfer part of their energy back to the large-scale ocean currents. This ocean energy cycle is not fully simulated in numerical models, but it plays an important role in transporting heat, carbon, and nutrients throughout the world’s oceans. The purpose of this study is to quantify the ocean energy cycle by using fine-scale idealized numerical simulations of the Atlantic and Southern Oceans. Our results provide a basis for how to include unrepresented energy exchanges in coarse global climate models.
Hurricanes Laura and Sally: A Case Study of Evacuation Decision-Making in the Age of COVID-19
Authors: Collins Jennifer , Polen Amy , Dunn Elizabeth , Jernigan Isabelle , McSweeney Killian , Welford Mark , Lackovic Michelle , Colón-Burgos Delián , Zhu Yi-Jie
Published: September 2022

This study examines risk perceptions and evacuation planning for those residents affected by Hurricane Laura—the first major hurricane evacuation during the COVID-19 pandemic—and Hurricane Sally, prior to the widespread availability of vaccines. Research on hurricane evacuation behavior and risk perceptions during a pandemic is critical for quantifying the intersect of these compounding threats. Analyses captured how people perceive public shelters and whether evacuation choices changed in light of the pandemic. Many study participants considered themselves vulnerable to COVID-19 (39.4%), and two-thirds believed it would be “very serious” if they or their loved ones contracted COVID-19, but this had no impact on their actual evacuation decision-making. Approximately 75% of the sample stayed at home during Hurricanes Laura or Sally, and, of these, just over 80% indicated that COVID-19 was a somewhat important deciding factor. This reflects the partial role that COVID-19 played in balancing individual and household protective action decision-making during complex disasters, whereas 15.5% wanted to evacuate but waited until it was too late. For those who evacuated to a hotel, many found that staff and guests wore masks and socially distanced in common spaces. Of particular interest is that individuals have a continued negative perception of public shelters’ ability to safeguard against COVID-19 that was coupled with a significant decrease in the number of respondents that would potentially use shelters in 2020 as compared with before the COVID-19 pandemic. These results have informed and will inform future hazard mitigation planning during the current pandemic or future pandemics or infectious disease outbreaks.