bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i) with Cardiac Arrhythmias: A Systematic Review and Meta-Analysis of Cardiovascular Outcome Trials
Authors: Wang Xujie , Zhang Xuexue , Zhang Wantong , Li Jiaxi , Weng Weiliang , Li Qiuyan
Published: September 2023

Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a class of widely used hypoglycemic agents for the treatment of type 2 diabetes mellitus (T2DM). In addition to lowering blood glucose, SGLT2i protects the heart and kidney, significantly reduces cardiovascular events, and delays the progression of heart failure and chronic kidney disease. However, previous studies have not exhaustively discussed the association between SGLT2i and the risk of developing cardiac arrhythmias. The purpose of this study is to assess the association of SGLT2i with cardiac arrhythmias in patients with T2DM and without T2DM in cardiovascular outcome trials (CVOTs). Methods: We performed a meta-analysis and systematic review of CVOTs that compared SGLT2i with placebo. MEDLINE, Web of Science, The Cochrane Library and Embase were systematically searched from inception to December 2022. We included CVOTs reporting cardiovascular or renal outcomes with a follow-up duration of at least 6 months. Results: A total of 12 CVOTs with 77,470 participants were included in this meta-analysis (42,016 SGLT2i vs 35,454 control), including patients with T2DM, heart failure (HF), or chronic kidney disease (CKD). Follow-up duration ranged from 9 months to 5.65 years. Medications included empagliflozin, canagliflozin, dapagliflozin and ertugliflozin. SGLT2i were associated with a lower risk of tachycardia (risk ratio (RR) 0.86; 95% confidence interval (CI) 0.79–0.95), supraventricular tachycardia (SVT; RR 0.84; 95% CI 0.75–0.94), atrial fibrillation (AF; RR 0.86; 95% CI 0.75–0.97) and atrial flutter (AFL; RR 0.75; 95% CI 0.57–0.99) in patients with T2DM, HF and CKD. SGLT2i could also reduce the risk of cardiac arrest in CKD patients (RR 0.50; 95% CI 0.26–0.95). Besides, SGLT2i therapy was not associated with a lower risk of ventricular arrhythmia and bradycardia. Conclusions: SGLT2i therapy is associated with significantly reduced the risk of tachycardia, SVT, AF, and AFL in patients with T2DM, HF, and CKD. In addition, SGLT2i could also reduce the risk of cardiac arrest in CKD patients. Further researches are needed to fully elucidate the antiarrhythmic mechanism of SGLT2i.
ScholarOne - Strengthening Biomedical Ethics in Africa - lessons from a Cabo Verde clinical trial case
Authors: Lima Mendonça Maria da Luz , Araújo Isabel , Delgado António Pedro , Stabell Benn Christine , Ferrinho Paulo , Fronteira Inês
Published: September 2023

The uncertainties caused by the COVID-19 pandemic have stimulated biomedical research worldwide to support evidence-based public health policies aimed at reducing the impact of COVID-19 on populations. the resulting urgency of decision-making in a pandemic context faced by Research Ethics Committees created new challenges leading to new reflections on the basic principles of ethics.
Starting from a specific case of the implementation of a clinical trial in a pandemic context, this article analyses the emerging ethical and regulatory challenges for the development of clinical trials in Cabo Verde and the path towards strengthening clinical research and biomedical research ethical decision-making in the country.
Research in health is important for the social development of a country. Legal and ethical gaps related to biomedical research can be overcome to make clinical research possible, as was the case in Cabo Verde and, thus, contribute to the overall development of well-regulated science.
The Streets Speak: Unravelling the Impact of Austerity on Public Protests during the the Great Recession
Authors: Wang Chendi
Published: September 2023

This paper examines the impact of austerity policy announcements on protest mobilisation in 16 European countries during the Great Recession. It argues that austerity policies politicised grievances and enabled blame attribution, while institutional constraints and protest fatigue dampened reactions to later policies. Using monthly protest event data and systematically coded austerity policy announcements, the study utilises an interrupted time series design to analyse austerity announcements as shocks to protest levels. The findings indicate that earlier austerity announcements significantly increased economic protest levels, while later announcements had no effect or even decreased protest. Furthermore, the impact of austerity on protest was conditioned by economic and political contexts. Austerity had a larger effect when accompanied by rising unemployment, worsening household finances, external actor involvement, and higher prior protest levels. The study contributes to understanding varied public reactions to austerity and the dynamics between economic crisis, government policies, and contentious politics.
Conservation of Baryon and Lepton Number is an Effect of Electric and Magnetic Charges
Authors: Kühne Rainer Walter
Published: September 2023

The conservation of baryon number and lepton number has not yet been explained. Here I present a new nomenclature where I redefine isospin and hypercharge. By doing so I explain baryon and lepton number conservation as an effect of the electric-magnetic duality and the U(1) x U(1) gauge symmetry of quantum electromagnetodynamics. By using this method I predict the quantum numbers of an octet of magnetic monopoles. Another surprising result is that both leptons and quarks have nonzero magnetic isospin, a new quantum number.
Membangun Kepemimpinan Yang Efektif
Authors: Abuk Maria Sintia Hartanti
Published: September 2023

Kepemimpinan yang efektif mampu mempengaruhi, mendorong, mendidik serta bertanggung jawab kepada anggotanya dan kepemimpinan yang efektif adalah ide atau gagasan-gagasan, pengalaman, serta wawasan yang luas. Metode kepustakaan yang digunakan dalam kajian penelitian ini yang mengacu pada pendekatan buku, jurnal dan media-media lainnya yang ada di perpustakaan. Tujuan dari penelitian ini supaya pemimpin bisa memaparkan tentang membangun kepemimpinan yang efektif dalam suatu organisasi. Hasil dari penelitian ini agar potensi yang dimiliki seorang pemimpin untuk mempengaruhi, menggerakkan, memotivasi, memelihara dan menjaga setiap anggotanya agar bekerja sesuai tugas dan tanggung jawab yang diberikan untuk mencapai suatu tujuan yang ditetapkan.
Polemik Gereja Menjadi Tempat Yang Aman bagi Anak
Authors: Niab Melda Sindayani
Published: September 2023

Anak merupakan makluk sosial yang membutuhkan pertumbuhan dan perkembangan dari orang dewasa. Saat ini anak terkadang menjadi bahan perdebatan atau diskusi bagi orang yang sangat peduli akan tumbuh dan kembang seorang anak, mulai dari masalah pelecehan seksual dan kemerosotan moral pada anak, serta adanya pernikahan dini. Dengan kehadiran gereja permasalahan yang dihadapi anak saat ini dapat menjadi solusi. Tujuan penelitian ini adalah supaya polemik (perdebatan atau diskusi) gereja menjadi tempat yang aman bagi anak serta melindungi anak dari setiap permasalahan yang terjadi. Metode penelitian yang di gunakan dalam penulisan ini adalah metode pustaka atau literatur yaitu pengumpulan data berhadapan dengan teks, buku, jurnal dan sumber lainnya yang tersedia di perpusatakan. Kegiatan ini dilakukan dengan menghimpun data dari barbagai literatur, baik perpustakan dan tempat lainnya. Dalam pembahasan ini masalah yang ditemukan digereja adalah pelecehan seksual yang terjadi pada anak dan juga pernikahan dini. Berdasarkan hasil penelitian disimpulkan ternyata banyak gereja yang belum menjadi tempat aman bagi anak-anak remaja khususnya dalam mencegah masalah yang saat ini terjadi dikarenakan gereja yang kurang memperhatikan pelayanan terhadap anak
Data Virtualization: A Game-Changer for Big Data Analytics
Authors: William Hannah
Published: September 2023

Data Virtualization: A Game-Changer for Big Data Analytics
Analisis Pengendalian Biaya Proses Produksi Tahu Tempe Pada UD Karya Maju Kecamatan Tanimbar Selatan Kabupaten Kepulauan Tanimbar
Authors: Akuntansi Program Studi
Published: September 2023

ABSTRAK Penelitian ini dilakuka pada UD Karya Maju Kecamatan Tanimbar Selatan Kabupaten Kepulauan Tanimbar.Ttujuan penelitian ini untuk mengetahui sejauh besar biaya Produksi tempetahu. Methode penelitian yang digunakan adalah penelitian kuantitatif deskripsi. Teknik pengumpulan data yang dilakukan dengan melakukan wawancara, dokumentasi dan data sekunder yang didapatkan dari hasil wawancara. Teknik anlasis data yang digunakan adalah menghitung biaya bahan baku dan menghitung laba rugi, untuk mengetahui sejauhmana biaya yang dikeluarkan dan keuangan yang di dapatkan sehingga pengendalian biaya dapat menjadi bahan evaluasi bagi UD Karya Maju. Hasil penelitian ini adalah biaya yang mampu dikendalikan sehingga besar keuntungan dapat menutupi biaya walau terkadang usaha kecil mengenah produk tempe tahu ini mengaami kendala dalam persedihaan bahan baku dan daerah pemasaran yang belum dapat terpenuhi sesuai permintaan kosumen.
TONSL is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that tonsoku-like, DNA repair protein, encoded by TONSL, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. TONSL mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of TONSL in primary tumors was correlated with patient overall and distant metastasis-free survival. Modulation of TONSL expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
PRPF19 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that pre-mRNA processing factor 19, encoded by PRPF19, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. PRPF19 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of PRPF19 in primary tumors was correlated with overall and distant metastasis-free survival. Modulation of PRPF19 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Nickel Mine Exploitation In Indonesia, Between A Blessing And A Disaster Of Environmental Damage
Authors: naryono endang
Published: September 2023

Indonesia is one of the countries with the largest nickel mineral potential in the world with the greatest potential being in the heart of the island of Sulawesi and small islands in the North Maluku archipelago and Southeast Sulawesi. Based on data from the Ministry of Energy and Mineral Resources (ESDM), Indonesia has at least 72 million Nickel (Ni) reserves, including Limonit1, or 52% of the world's total nickel reserves of 139,419,000 Tons of Ni (Indonesian Nickel Investment Opportunities Booklet, Ministry of Energy and Mineral Resources , 2020). Therefore, most nickel mining activities are only spread across 4 provinces, which contain 90% of all nickel reserves in Indonesia. 3 provinces are in Sulawesi, namely Central Sulawesi, South Sulawesi and Southeast Sulawesi, as well as 1 province in Maluku, namely North Maluku. nickel mining, and the impact of nickel mining activities in Sulawesi. Previously, we will explain the whys and whys of policy directions related to nickel resources in Sulawesi in national and global development. This brief paper departs from experiences in Sulawesi in advocating for environmental sustainability and its impact on the lives of people in rural areas. Ambition to make Indonesia the number one battery producer in the world. To achieve such big ambitions, the Indonesian Government continues to boost the growth of the nickel mining industry, starting from upstream to downstream.
Complexity in the 3D stress fields of mid-ocean ridge tectonics: a manifestation of sub-crustal mush dynamics
Authors: Sen Joyjeet , Sarkar Shamik , Mandal Nibir
Published: September 2023

Mid-ocean ridge (MOR) systems evolve in strongly heterogeneous stress environments. However, the origin of such stress complexity still awaits a comprehensive explanation, which is the central theme of the present article. This study develops a thermo-mechanical model to demonstrate the multi-ordered 3D convective circulations, produced by decompression melting in the mushy region, as the key factor to modulate the MOR dynamics. The model mechanically couples the sub-ridge mushy regions with the elastic crustal layer within a mathematical framework of fluid-structure interaction (FSI) mechanics. FSI model simulations show that the heterogeneous stress field of a MOR forms characteristic segmented patterns on a time scale of million years, resembling axial as well as off-axis topographic morphologies observed in MORs. This article provides a model calculated estimate of the total stress tensor, focusing on the following components: across- and along-axis horizontal tension / compression (σ⟂ and σ∥) and across-axis horizontal shear stress (σ#) that dominantly control the ridge-axis morphologies. The stress mapping reveals a distinct 30 km wide axial zone of tensile σ⟂ localization (median < 250 MPa), whereas compressive σ⟂ localization (median < 100 MPa) in off-axis ridge-parallel linear belts on either side of the MOR axis. This finding leads to an alternative explanation for the off-axis ridge-parallel second-order hill topography, located at a distance of 20 km to 50 km, as a consequence of compressional σ⟂ localization. Along-axis compressional σ∥ concentrates in a row of ridge-normal narrow, 10 to 30 km wide stripes, giving rise to segmentation of the stress field on a wavelength of 40-150 km, which conforms to the second-order magmatic segmentation patterns of MORs. From σ# mapping, it is also shown that ridge-transverse discontinuities, including transform offsets and transpression zones originate spontaneously from the FSI interactions during the MOR evolution.
Order of first-play in simulated versus monetary gambling
Authors: Russell Alex M T , Hing Nerilee , Newall Philip Warren Stirling , Greer Nancy , Dittman Cassy , Thorne Hannah , Rockloff Matthew
Published: September 2023

Background and aimsSimulated gambling products, like loot boxes and social casino games, contain gambling elements, but are not classified as gambling. They are available to minors, raising concerns about a “gateway effect” into gambling. This study examined the time course of young people’s engagement in simulated and monetary gambling, and associations between simulated gambling and gambling problems and harm. A necessary, although not sufficient, condition for simulated games leading to real money gambling is that simulated play must come first. MethodParticipants were 1,026 young adults (aged 18-25 years) who played video games in the last year. They reported the age at which they first took part in seven simulated and twelve monetary gambling products, and current gambling problems and harm.ResultsFirst use of loot boxes and video games with gambling content tended to precede monetary gambling. Forms where gambling is a core gameplay element, such as social casino and demonstration games, tended to follow some monetary gambling forms. Engagement in most simulated gambling products was associated with greater harm from monetary gambling.DiscussionThe findings leave open the possibility of a catalyst pathway from youth engagement in loot boxes and games with gambling content to later monetary gambling, but causal psychosocial mechanisms remain unclear. However, a pathway from social casino and demonstration games to monetary gambling appears less likely, which may instead reflect containment or substitution effects. Simulated gambling disproportionately attracts youth who are vulnerable to gambling problems and harm, indicating the need for consumer protection measures.
Understanding the Structure of Autobiographical Memories: A Study of Trauma Memories from the 1994 Rwandan genocide
Authors: Blumenthal Anna , Caparos Serge , Blanchette Isabelle
Published: September 2023

How do we remember traumatic events, and are these memories different in individuals who experience post-traumatic stress? Some evidence suggests that traumatic events are mnemonically enhanced, or include more episodic detail, relative to other types of memories. Simultaneously, individuals with PTSD have more non-episodic details in all of their memories, a pattern hypothesized to result from impairment in executive function. Here, we explore these questions in a unique population that experienced severely traumatic events more than 20 years ago – individuals who lived through the 1994 Genocide in Rwanda. Participants recalled events from the genocide, negative events unrelated to the genocide, neutral events, and positive events. We used the Autobiographical Interview Method to label memory details as episodic or non-episodic. We found that memories from the genocide showed robust mnemonic enhancement, with more episodic than non-episodic details, and contained more details overall than any other memory type. This pattern was not impacted by post-traumatic stress. Overall, this study provides evidence that traumatic events create vivid long-lasting episodic memories, in this case even more than 20 years later.
Beyond Gentrification: Housing Loss, Poverty, and the Geography of Displacement
Authors: Hepburn Peter , Louis Renee , Desmond Matthew
Published: September 2023

We assess the relationship between gentrification and a key form of displacement: eviction. Drawing on over six million court cases filed in 72 of the largest metropolitan areas across the United States between 2000 and 2016, we show that most evictions occurred in low-income neighborhoods that did not gentrify. Over time, eviction rates decreased more in gentrifying neighborhoods than in comparable low-income neighborhoods. Results were robust to multiple specifications and alternative measures of gentrification. The findings of this study imply that focusing on gentrifying neighborhoods as the primarily site of displacement risks overlooking most instances of forced removal. Disadvantaged communities experienced displacement pressures when they underwent gentrification and when they did not. Eviction is not a passing trend in low-income neighborhoods—one that comes and goes as gentrification accelerates and decelerates—but a durable component of neighborhood disadvantage.
Die Bildungsungleichheit der Schulentwicklungsforschung. Reflexionsprobleme zwischen wissenschaftlichen Problemkonstruktionen und politischen Lösungsroutinen
Authors: Emmerich Marcus
Published: September 2023

Der Beitrag befasst sich mit der Frage, in welcher Form Bildungsungleichheit einen Gegenstand für die Schulentwicklungsforschung (SEF) darstellt, und fokussiert hierbei die Theorieannahmen ihrer Problembeschreibungen. Ausgehend von einer eigenen Systematisierung soziologischer Erklärungsschemata zur Genese von Bildungsungleichheit – dem „gruppistischen“, dem „phylogenetischen“ und dem „operativen“ Schema – wird die Übernahme dieser Schemata in die Problemkonstruktion der SEF kritisch diskutiert. Problematisiert wird hierbei, dass die Fokussierung auf „gruppistisch-phylogenetische“ Erklärungen dazu führt, schulexterne, durch Schulentwicklung nicht beeinflussbare distale Ursachen von Bildungsungleichheit zu betonen, während proximale „operative“ Schulfaktoren (Differenzierungs- und Organisationshandeln), die durch Schulentwicklung und entsprechende bildungspolitische Programme erreichbar wären, paradoxerweise nicht bzw. kaum systematisch zum Ausgangspunkt für Analyse und Programmatik gemacht werden.
Plädoyer für eine neue methodische Übereinkunft. Zum Potenzial von randomisiert-kontrollierten Studien in der Evaluation von Schulentwicklungsprogrammen
Authors: Erdmann Melinda , Helbig Marcel , Pietrzyk Irena
Published: September 2023

In diesem Beitrag plädieren wir für eine Verständigung zwischen verschiedenen Akteur*innen über methodische Standards bei der Evaluation von Schulentwicklungsprogrammen, die zur Reduzierung von Bildungsungleichheit eingesetzt werden. Ziel einer solchen Verständigung wäre es, geteiltes Wissen über methodische Fragen aufzubauen und eine breit akzeptierte Einigung darüber zu erreichen, welche Forschungsmethoden als sinnvoll und verlässlich für die Beurteilung von Schulentwicklungsprozessen gelten. Wir sind der Ansicht, dass ergänzend zu den bislang hauptsächlich durchgeführten Prozessevaluationen Wirkungsevaluationen, und hier insbesondere randomisiert-kontrollierte Studien, einen zentralen Baustein in der Bewertung von in der Schule angesiedelten Programmen darstellen sollten.
Prospects and Potential of Buckwheat (Fagopyrum spp) Production in Nepal: A Review
Authors: Adhikari Bishnu Bilas
Published: September 2023

Buckwheat is one of the important but underexploited crop of Nepal. It ranks 6th position as a staple food crop and is cultivated from Terai to mid hills and mountains.  It is cultivated as summer crop in mountains, autumn and spring crop in mid-hills and winter crop in Terai and inner terai. The major buckwheat producing districts of Nepal are Mustang, Humla, Dolpa, Mugu, Kalikot, Jumla, Rukum, Rolpa, Jajarkot, Kavre, Dolakha, Solukhumbu, Okhaldhunga and Taplejung. It is considered as a short duration, eco-friendly, drought tolerant, wider adoptive and rainfed loving crop with minimal requirement of plant nutrients, tilling, plant protection measures and other management practices. It plays an important role in the food and nutritional security of the people living in remote rural areas. Two buckwheat species; Fagopyrum. esculentum (Mithe phaper) and Fagopyrum. tataricum (Tite phapar) are cultivated in Nepal.  It can withstand against various kinds of biotic and abiotic stresses and fit well in various multiple cropping systems. The area, production and productivity of buckwheat in Nepal during fiscal year 2021/022 is 13875 ha, 15917 tons and 1.15 tons ha-1, respectively. Several factors such as frost, drought, lack of high yielding varieties, lodging, self-incompatibility, female sterility, indeterminant growth habit, shattering is responsible for low yield. To increase the area, production and productivity of buckwheat in Nepal, immediate attention should be given by the researchers, development workers, local governments, and policy makers by developing and advocating location specific scientific interventions and policies.
Rancangan Urutan Penambangan Batubara Mingguan Bulan April 2022 Berdasarkan Ketersediaan Alat Mekanis Di Tambang Terbuka Pit B Utara PT. Prima Sarana Gemilang, Job Site PT. Pada Idi, Desa Luwe Hulu, Provinsi Kalimantan Tengah
Authors: Akhyar Rafi Dzarbila , Nursanto Edy , Inmarlinianto Inmarlinianto , Haq Shofa Rijalul
Published: September 2023

PT. Prima Sarana Gemilang (PT. PSG) adalah kontraktor pertambangan dan konstruksi umum di Indonesia. Perusahaan ini mempunyai salah satu jobsite penambangan di PT. Pada Idi yang berlokasi di Desa Luwe Hulu, Kecamatan Lahei Barat, Kabupaten Barito Utara, Provinsi Kalimantan Tengah. Sistem penambangan yang digunakan yaitu sistem tambang terbuka dengan metode strip mine coal mining. PT. PSG memiliki target produksi overburden sebesar 800.000 BCM/ bulan dan batubara sebesar 60.000 MT dengan nilai stripping ratio maksimal 12: 1. Penelitian ini bertujuan untuk membuat rancangan urutan penambangan batubara mingguan pada bulan April 2022 yang meliputi forecast production berdasarkan ketersediaan alat, rancangan kemajuan penambangan mingguan, dan rancangan disposal mingguan. Metodelogi penelitian yang dilakukan menggunakan studi literatur untuk mencari referensi yang mendukung penelitian ini. Kemudian melakukan studi lapangan mengenai permasalahan yang ada di PT. Prima Sarana Gemilang. Data yang dibutuhkan dalam penelitian ini berupa data primer dan sekunder. Data yang telah didapat kemudian diolah dan dianalisis menggunakan software Microsoft excel dan Minescape 5.7 sehingga menghasilkan suatu kesimpulan berupa rancangan urutan penambangan mingguan yang memenuhi perhitungan forecast production dengan rencana target produksi penambangan batubara sebesar 820.837 ton/tahun untuk overburden dan 70.154 MT untuk batubara. Rancangan urutan penambangan mingguan dibuat didasarkan pada rencana target produksi yang telah ditentukan dengan kapasitas besaran dilebihkan 2% untuk menggantikan kehilangan dari proses pengangkutan. Rancangan disposal terletak 1000 m di sebelah barat laut dari pit A. Total kapasitas disposal berdasarkan desain sebesar 1,042,463 LCM. Besarnya kapasitas disposal lebih besar 2% setiap minggunya terhadap reserve berdasarkan desain dengan jenis timbunan yang diterapkan adalah terrance dump. Jenis timbunan terrance dump dipilih karena topografi di daerah penelitian tidak begitu curam. Kebutuhan alat pada setiap minggunya berbeda-beda dikarenakan faktor ketersediaan alat berat dan jarak menuju disposal.
ÜLSERATİF KOLİTLİ HASTALARDA SERUM HEPSİDİN DÜZEYİ ÖLÇÜMÜNÜN HASTALIK AKTİVASYONUNU DEĞERLENDİRMEDEKİ ETKİNLİĞİ VE GÜVENİRLİĞİ
Authors: KAŞIKÇI Efe Emre , ÇELİK Mustafa , AKPINAR Kadriye
Published: September 2023

Adı soyadı: Efe Emre KAŞIKÇI

Doğum tarihi: 24.01.1989

Yabancı dil bilgisi: İngilizce

Görev yeri: Suat Seren Göğüs Hastalıkalrı Hastanesi- İç Hastalıkları / Alerji ve Klinik

İmmünoloji Bilim Dalı

E-posta adresi: efemre@gmail.com

Telefon: 05077926171

EĞİTİM BİLGİLERİ

Tıp Fakültesi Selçuk Üniversitesi Tıp Fakültesi 2008-20014

İç Hastalıkları Pamukkale Tıp Fakültesi 2015-2019

Alerji İmmünoloji Suat Seren Göğüüs Hastalıkları SBÜ 2020-
Primary Myoglobinuria: A Case Report
Authors: Bunao Romulo
Published: September 2023

The presence of the red pigment myoglobin in the urine is a noteworthy sign of a rare myopathy. Myoglobin is a respiratory pigment composed of an iron-containing component, protoporphyrin, and a protein component — globin, found in muscles. Because of its small molecular size and lack of plasma protein binding capacity myoglobin is filtered by the kidneys very readily; almost twenty-five times more than hemoglobin1.
Two Entirely Different Angiographic Manifestitations of Localized Hydronephrosis: Report of Two Cases
Authors: Kikkawa Kaz , Littleton Jesse T. , Ty James
Published: September 2023

The angiographic characteristics of hydronephrosis have been well documented1, and recently localized hydronephrosis masquerading as renal neoplasm was reported by Bosniak and his associates2. Renal angiography as a useful diagnostic tool in establishing the correct diagnosis of hydronephrosis in the duplicated kidney was emphasized by Gross and Chait3. We have recently encountered two cases of almost identical localized hydronephrosis, each of which demonstrated entirely different angiographic manifestations, for the reason that one of the kidneys received a dual blood supply. This communication is based upon these two cases, suggesting that there may not be a characteristic angiographic appearance of localized hydronephrosis in the kidney with supernumerary arteries.
Legs are Made for Walking
Authors: Bensam B. J. , Tippett R. J. , Danko J. F.
Published: September 2023

In the five or so years since the introduction of the concept of early weightbearing following amputations, surgical acceptance has gone from enthusiasm to rejection and back again. This report is prompted by the coincidental appearance in our Orthopedic Clinic of three recent amputees. An orthotist was present, and a discussion of current views in the general geographic area served by his company seemed to suggest that the initial enthusiasm resulted in too great expectations from the various techniques. The three patients serve to document the success of the concept, and it warrants further discussion.
Modern Concepts in the Treatment of Hodgkin’s Disease
Authors: Carpender James W. J. , Bosselli Bruce
Published: September 2023

The use of chemotherapy, principally Nitrogen Mustard, which became widespread in the late 1940’s, radically changed the management of Hodgkin’s disease. This may not have been in the direction of better management of these patients as we will point out later. In 1950 Peters1 first suggested the need for a new concept in radiotherapeutic management which has now become the accepted primary method of treatment. Her first impressions given at that time were confirmed in 19582 and again in I9633. This work has also been confirmed by Kaplan4 who also supported the argument that much higher doses of radiation are needed for local or general cures than had been used in the past.
Use of Medium Chain Triglyceride Diet in the Management of Malabsorption Syndrome Due to Massive Resection of the Small Bowel in a Newborn
Authors: Weeks James H.
Published: September 2023

Occasionally it is necessary to resect a large portion of the small intestine in a newborn or young infant. This may result in a significant malabsorption syndrome. In the past, the treatment of such a malab-sorption problem has been frequently difficult and inadequate for normal nutrition and growth.
S. Typhii Osteomyelitis. A Long Delayed Time Bomb?
Authors: King Arthur B.
Published: September 2023

In these days when the infectious gastrointestinal diseases are becoming as rare as the proverbial hen’s teeth, the rugged persistence of some of the forms of bacterial life tend to be overlooked. There seems to be little doubt that bacteria were well established on this orb long before the arrival of the lone species of biped mammals parading under the cognomen of Homo Sapiens. Try as he might, even with the help of his expanded cortex, he has yet to completely eradicate any of the ubiquitous bacteria that have established themselves under what was probably far harsher environmental conditions than those on which man now seems to be thriving so plentifully.
Progressive Supranuclear Palsy — A Very Rare Entity: Report of a Case
Authors: Shelling Richard E. , McQuillen James B.
Published: September 2023

Progressive supranuclear palsy was first recognized as a clinical entity in 1954 by Steele, Richardson, and Olszewski1. Cases had been described previously but their uniqueness was not appreciated. To date 32 cases have been reported2. We recently observed such a patient.
“Conflicts in Clinial Researh”
Authors: Brilhart Kenneth B.
Published: September 2023

I can bring to this meeting only the opinion of a single medical practitioner with a meager knowledge of the law as well as exposure to the pharmaceutical industry. At the risk of upsetting some of you, I must maintain this simple point of view. When the moment comes for making decisions whose consequences may be a matter of life or death, the doctor faced with the patient ought not to have to ask himself whether what he proposes to do may later have legal consequences. To come to a decision on grounds of conscience is quite different from making it on legal grounds. I am even bold enough to think that this is a good thing, for anything else would be likely to paralyze initiative and act to the prejudice of the patient.
Society’s Responsibility to Medicine: Government as a Catalyst in the Planning and Delivery of Total Health Care
Authors: Olson Stanley W.
Published: September 2023

The distinguished Guthrie Lecturers whom you have invited in past years have chosen to direct their remarks chiefly to the experiences of medical men whom history has marked for distinction. Many of those historical figures were contemporaries of Dr. Donald Guthrie and, in reviewing their significant work, light was shed on the circumstances under which he did his important work. I regret that I never knew Dr. Guthrie personally. However, Dr. Donald Balfour, Director of the Mayo Foundation, with whom I worked, knew him well and spoke often and with great admiration of this skillful surgeon and of his abilities as a leader of men. I count it an honor to speak to you tonight in memory of Dr. Guthrie.
Cellular Immune Response to Mastectomy and Radiation
Authors: Meyer Kenneth K. , Boselli Bruce D. , Weaver Donald R. , Luft William C.
Published: September 2023

Mastectomy for breast cancer results in increased patient survival, but radiation after mastectomy adds no additional benefit1-2. The reason X-ray therapy does not enhance survival may be that it destroys lymph nodes and thymus in addition to killing tumor cells. The resultant inhibition of lympho-cellular immune mechanisms may be an important detrimental effect of postmastectomy radiation. The cellular immune system is both hormone and radiation sensitive3. We began this study because, concurrently with increased use of radiation after mastectomy, the distribution of breast cancer metastases has changed and their responsiveness to hormonal therapy decreased4,5,6. We postulated that the failure of radiation to improve survival and the changed distribution of responsiveness to breast cancer metastases may result from radiation inhibition of the lymphocyte immune system. We investigated the effect of radiation on the absolute lymphocyte count and found that it induced a prolonged reduction in the total lymphocyte level and, thus, may modify the characteristics of host defense against tumor.
South Africa’s New Clean Operating Enclosure: A Report of a Recent Visit
Authors: Beck William C.
Published: September 2023

The four Provinces which constitute the Union of South Africa support a most interesting and unusual organization called the Council for Scientific and Industrial Research. In its buildings it appears much like our National Institutes of Health complex in Bethesda, Maryland, a series of large buildings in a park, a city in itself. In this South African compound, all manner of research is carried out: water pollution studies, agricultural pest control, as well as consumer items research.
Ski Injuries
Authors: Steinbach William
Published: September 2023

In the beginning, skis were used as a practical means of transportation in those areas of the world where snow covered the ground for a better part of the year. In Stockholm, Sweden, there is on display, a pair of skis 5,000 years old. These are made of bone. Later, wood was substituted for the bone in skis. At the Battle of Oslo, fought in 1200 between Sweden and Norway, skiers were used as Norwegian scouts. In the 1800’s, Norwegian immigrants brought skiing to the United States, and again it was used as a practical method of transportation; i.e. getting to and from camps and mining towns in the western part of the United States. More recently, the technique of skiing has emerged as an extremely popular sport and names like Art Devlin, Tony Sailor, Penny Patou, Billy Kidd, and Jean Claude Killy are as well known by the general public as by the skiing aficionado. Equipment has become more sophisticated with special boots, “safety bindings” and metal or plastic skis. Skiing is now not only a popular recreational past-time, but a very large business, and a small, but persistent public health problem.
Jet Action
Authors: Antes Jean
Published: September 2023

The shrinking of the world by jet-age travel and the population explosion have made imperative the need for a jet-age instrument which can help solve some of the medical problems of our time. Such an instrument is the jet injector, using no needle, which has already saved millions from the threat of smallpox, measles, poliomyelitis, and other preventable communicable diseases. The story of the development of the jet injector and its use, not only in facilitating immunization but also in other medical activities began, for the most part, with the work of Dr. Robert A. Hingson, Professor of Anesthesiology at the University of Pittsburgh School of Medicine.
The Hospital Based Cancer Program
Authors: Beck William C.
Published: September 2023

The diagnosis and management of cancer is becoming ever more complex. The disease is changing in its manifestations: in its relative incidence as well as in its therapy and prognosis. New drugs are employed to check rapidity of invasion in new combinations and sequences of their application as well as in their integration into the older therapeutic routines. Hormones are no longer just added or removed, but now they are manipulated and adjusted to reduce the mortality as well as the morbidity and suffering.
A Comparative Study of Selected Physician Values: Solo Practice Vs. Multi-Specialty Group Physicians. Part I
Authors: Dooley James J.
Published: September 2023

Ed. Note: This is the first of two parts of an article based on a study of physician values in solo practice and in multi-specialty group practice. The study was made during Mr. Dooley’s residency at the Robert Packer Hospital as partial fulfillment of requirements for a degree in Hospital Administration. Mr. Dooley is a student in the School of Public Health, University of Minnesota. Part I deals with the objectives and methods of the survey, and Part II will present the findings of the study. The work was funded, in part, by a research grant of the Donald Guthrie Foundation for Medical Research, Sayre, Pennsylvania. Project No. 71-11.
Qualitative characteristics of the fungus Cyclocybe aegerita strains 2229, 2230, 2231 IBK under industrial cultivation conditions
Authors: Bandura I. , Kulyk A. , Makohon S. , Tsyz O. , Khareba O. , Khareba V. , Kovtuniuk Z.
Published: September 2023

Poplar mushroom is characterised by attractive fruiting bodies in terms of appearance and taste. Cyclocybe aegerita mushrooms are also known to contain unique substances, including proteins, polysaccharides, and aromatic substances with proven nutritional value and medicinal effects. However, the lack of a sound cultivation technology using available plant material limits the saturation of the domestic market with mushrooms of this species. Three strains of C. aegerita from the IBK National Collection of Agaricale Cultures of the Institute of Ecology and Natural Resources were studied for their potential introduction into commercial culture. It was determined that strains 2230 and 2231 have a vegetation cycle of 42 days compared to 46-64 days for the previously studied strains. The highest yield in the experiment was obtained for strain 2231, which ranged from 217 to 220 g per kilogram of a substrate over three cultivation cycles. The biological efficiency of the strains according to the results of the first wave of fruiting ranged from 20.2 (2229) to 60.4% (2231), which is consistent with the published data of other researchers. The appearance and parameters of the fruiting bodies of the strains, which differed in both the colour of the pileus and the size, were described in detail. Under microclimatic conditions of the experiment, strains 2230 and 2231 had a rich brown colour of pilei, while the formed fruit bodies of strain 2229 were distinguished by a pleasant milky cream colour. The largest fruiting bodies in terms of weight were obtained by cultivation of strain 2229 (7.5 ± 0.4 g), which is on average 2 g higher than the weight of mushrooms of other studied strains. The highest fruiting bodies were discovered in strain 2230 having a height of 91.0 ± 1.8 mm, which also had the widest pilei with a diameter of 29.5 ± 0.9 mm. The largest stem diameter, which reached an average of 10.8 ± 0.3 mm, was detected in the fruiting bodies of strain 2229. This study investigated the variability of morphological traits and identified trends in the number of fruiting bodies of a certain size in the total volume of collected mushrooms, which facilitates the design of packaging and marketing campaigns
BUKU DOKUMENTASI FOTOGRAFI “KELENTENG BOEN SAN BIO”
Authors: Kaparang Martinus Eko Prasetyo , Everlin Shierly , Eva Angelina Theresia
Published: September 2023

Kelenteng merupakan bangunan keagamaan yang menjadi warisan cagar budaya. Menjadi nilai sejarah dari budaya Tionghoa, Kelenteng merupakan tempat penghormatan para leluhur (rumah abu) dan Dewa Dewi dengan banyak berbagai macam ornamen khas Tiongkok serta patung-patung Dewa-Dewi dari kepercayaan Konghucu lengkap dengan senjata khasnya, altar lengkap dengan tempat peletakan dupa untuk beribadah. Kelenteng Boen San Bio di bangun pada tahun 1689 oleh pedagang Tiongkok. Tujuan dibuatnya perancangan buku ini adalah untuk mengenalkan kepada masyarakat luas mengenai sejarah dibangun-nya Kelenteng Boen San Bio, serta menjaga cagar budaya Tionghoa di Indonesia. Penelitian ini menggunakan metode deskriptif dan kualitatif,  penelitian untuk mencari informasi yang akurat mengenai sejarah, perkembangan, budaya bangunan kelenteng “Boen San Bio” serta faktual dan mendetail mengenai arsitektur mulai dari bagian utama, hingga bangunan pada sisi lainnya seperti sisi barat, sisi timur, sisi utara dan selatan yang didokumentasikan dalam media fotografi untuk menghasilkan buku dokumentasi fotografi. Dengan adanya buku fotografi, diharapkan menjadi dokumentasi informasi pengenalan mengenai Klenteng Bio San Bio untuk pertama kalinya.
Incapacitation and real estate trading. A case study
Authors: Bagan-Kurluta Katarzyna , Michalak Krzysztof
Published: September 2023

Motives: Incapacitation is presented in the literature as an important legal device for protecting the rights of the persons concerned. At the same time, in some cases (such as legal transactions with foreign countries), the legal consequences of incapacitation seem to be disproportionate to the protected interests. This overview aims to present a short case study that highlights the differences in the interests, possible views and demands of the parties in transactions involving real estate owned by incapacitated persons.
Aim: To initiate a debate on the degree of necessary legal protection in transactions involving real estate owned by incapacitated persons, and to analyze in a discursive manner the jurisdictional, procedural, and socioeconomic dimensions of a single problem in a short case study.
Results: Depending on the context, incapacitation can be both a form of protection and a difficulty in particular civil cases involving parties with limitations or residing in different jurisdictions.
Folklore in fashion- preserving intangible cultural heritage through fashion.
Authors:   Department of Textile & Apparel Engineering, University of Moratuwa, Sri Lanka, Thilakarathne S. , Gopura S. ,   Department of Textile & Apparel Engineering,University of Moratuwa, Sri Lanka, Wickramasinghe A . ,   Department of Textile & Apparel Engineering,University of Moratuwa, Sri Lanka, Payne A ,   School of Fashion and Textiles at RMIT University, Australia
Published: September 2023

Folklore has been an integral part of Sri Lankan culture for centuries and the story of Kuweni is one such entrancing narrative with historical significance, since it is directly linked to the origin of the Sinhalese nation. Kuweni’s importance extends beyond folk narratives and is also evident in ancient literature, describing her as a superhuman being, yet her true identity remains shrouded in mystery. Her shape-shifting abilities, as described in various legends, make Kuweni a fascinating character worthy of contemplation from many perspectives. Folklore is distinct from mythology, as it contains factual elements such as practices and customs that have a solid sociological background. Therefore, it is essential to preserve them ensuring that future generations can benefit from the sociocultural and anthropological values embedded to narratives. Folklore in Fashion PhD study addresses the crucial question of how to preserve folklore in a way that resonates with contemporary society.
ANALISIS WEBSITE E-GOVERNMENT KECAMATAN MENGGUNAKAN METODE USABILITY TESTING
Authors: Sri Hijriah  , Dedi Irawan
Published: September 2023

E-government (Pemerintahan elektronik) merupakan penggunaan teknologi informasi dan komunikasi (TIK) dalam proses pemerintahan untuk meningkatkan kinerja, efisiensi, dan kualitas layanan publik. Salah satu contoh penggunaan e- government ialah website di kecamatan sungai pinang, untuk mencapai tujuan dari website kecamatan, sangat penting untuk melakukan analisis usability yang bertujuan untuk mengukur tingkat kemudahan, kenyamanan, dan kepuasan pengguna saat menggunakan website tersebut. Analisis usability bertujuan untuk memastikan bahwa website kecamatan dapat memberikan pengalaman pengguna yang optimal dan memenuhi kebutuhan serta harapan pengguna. Analisis ini dapat dilakukan menggunakan metode usability testing yang merupakan suatu metode pengujian perangkat lunak atau produk untuk menganalisis sejauh mana produk tersebut dapat digunakan dengan efektif dan efisien. usability testing memiliki lima komponen, yaitu learnability, efficiency, memorability, errors, dan satisfaction. Tujuan dari penelitian ini adalah untuk mendapatkan hasil pengujian usability dari website kecamatan.
Long-term effectiveness of radiofrequency renal denervation in patients with resistant arterial hypertension (10-year follow-up results)
Authors: Rekovets O.L. , Sirenko Yu.M. , Torbas O.O. , Kushnir S.M. , Prymak G.F.
Published: September 2023

The aim – to determine the long-term efficacy and safety of renal denervation (RDN) at 10-year follow-up.Materials and methods. We selected 1146 patients with resistant arterial hypertension (RAH) who received 3 or more antihypertensive drugs. 16 patients were selected for renal artery denervation. RDN was performed in 8 patients (0.70 %). 8 patients refused the procedure. The age was 52.13 ± 3.88 years (40–66), the duration of hypertension was 16.75 ± 2.17 (12–25) years. The number of antihypertensive drugs was 5.5 ± 0.18. Office SBP/DBP on optimization of therapy in patients was 156.88/95.00 ± 2.98 mm Hg and heart rate – 68.88 ± 3.28 beats/min. 24SBP/DBP was 149.16 ± 5.40/86.98 ± 5.08 mm Hg. 24HR was 70.12 ± 2.94 beats/min. All patients tolerated the procedure well.Results and discussion. The decrease in office SBP/DBP was –12.59/–10.0 mm Hg; –11.17/–2.57 mm Hg; –20.31/–11.71 mm Hg, –27.71/–13.33 mm Hg and –30.21/–16.67 mm Hg, in the dynamics of 1 month, 12 months, 2 years, 5 years and 10 years, respectively, p <0.05 for all values compared to the initial. The office heart rate at the stages of 1 month, 6, 12 months, 2 years, 5 and 10 years decreased, its dynamics were –3.74 bpm, –4.68 bpm, –1.45 bpm, –2.13 bpm, –4.21 bpm, –3.88 bpm, respectively. The decrease in 24SBP/DBP was –14.45/–6.95 mmHg, –8.70/–10.01 mm Hg, –19.45/–12.37 mm Hg, –19.91/–11.24 mm Hg, –29.93/–13.61 mm Hg. and –26.13/–23.35 mm Hg (p<0.05 for all values). 24HR dynamics: –3.16 bpm, – 4.19 bpm, + 1.43 bpm, –1.51 bpm, –4.46 bpm, and –5.49 bpm, respectively. After 2, 5, and 10 years, all patients reached the target blood pressure level both in the office and with ABPM. Patients reduced the number of antihypertensive drugs from 5.50 ± 0.18 to 3.50 ± 0.30 – after 5 years and 3.67 ± 0.18 – after 10 years after RDN. GFR practically did not change over 10 years from 76.10 ± 5.62 to 64.60 ± 1.93 ml/min/1.73m2, p>0.05. One patient died of thyroid cancer 2 years later. All other patients are alive and have not had any cardiovascular event or death during 10 years.Conclusion. Long-term results of renal artery denervation showed no cases of cardiovascular events, development of diabetes or cardiovascular death over 10 years. RDN contributed to a reduction in the number of antihypertensive drugs from 5.5 to 3.67 after 10 years of therapy against the background of 100 % achievement of the target BP level.