bluuebunny/crossref_metadata_2025 huggingface dataset:
A scoping review on randomized controlled trials investigating effects of breathwork in women with breast cancer
Authors: Ganesan Vinitha , Kaiser Kathryn A. , Allada Anjani , Puppala Alekhya , White David K , Mugavero Mia , Maruvada Akhila , Kyle Jade , Gutta Harshitha , Jahan Nusrat , Gogineni Keerthi , Bell Megan , Aneja Ritu
Published: January 2025

Background: Patients with breast cancer experience distress, treatment-related discomfort, and fear of recurrence, from initial diagnosis through survivorship.
Aims: This study aimed to assess the effects of breathwork interventions on the mental health and quality of life of breast cancer patients and survivors.
Methods: We searched multiple databases for randomized controlled trials involving breathwork interventions in patients with breast cancer.
Results: Of the 5,909 items screened, 16 studies involving 1,726 participants met the inclusion criteria. Breathing interventions included yoga (n=9), qigong (n=4), and other breathing techniques (n=3). We found that the highest average risk of bias was in the randomization process, with challenges in accurately evaluating deviations from intended interventions due to unquantified adherence to at-home practices, although overall bias in the included studies was generally low. Interventions were prescribed daily or weekly, lasting from one week to two years. Outcomes included treatment side effects, fatigue, sleep, quality of life, biomarkers (e.g., inflammatory markers), psychosocial factors, anxiety, and depression.
Conclusions: Although positive outcomes were reported in domains of quality of life and emotional wellbeing, null findings were reported for vasomotor symptoms such as hot flashes for breathing interventions. The wide range of interventions and outcomes administered to patients in various phases of the breast cancer care continuum complicates firm conclusions. Recruitment and adherence issues were noted in multiple studies. Future research should standardize outcome measures, increase accessibility of the intervention (ie via Telehealth) to improve adherence, and include longer follow-up periods to evaluate survival and recurrence.
Evaluation and prediction of groundwater quality for irrigation using regression and machine learning models
Authors: Shaw Souvick Kumar , Sharma Anurag
Published: January 2025

This study evaluates and predicts six water quality indices such as sodium adsorption ratio (SAR), Kelly's ratio (KR), percentage sodium (%Na), permeability index (PI), exchangeable sodium percentage (ESP), and irrigation water quality index (IWQI) using multivariate regression models (MLR, PLSR, PCR, and WLSR) and machine learning (ML) algorithms (ANN, SVM, CART, CRRF, and KNN). The study analyzes data from 360 dug wells in Sundargarh district, India, during 2014–2021 with 70% used for training and 30% for testing. Spatial mapping of SAR, KR, ESP, and PI exhibits higher suitability of groundwater. The Mann–Kendall test of trend analysis shows a monotonic increasing and decreasing trend for SAR, KR, %Na, ESP, PI, and IWQI, respectively, at p > 0.05 during 2014–2021. Principal component analysis and discriminant analysis identify Na+, SAR, KR, %Na, and PI as the most influential WQ variables affecting the groundwater quality for this study area. MLR and WLSR models are superior in predicting SAR and ESP, while ANN is the best-suited ML model for SAR, KR, %Na, PI, and ESP. CRRF predicts IWQI with a relatively higher accuracy. These findings demonstrate the effectiveness of ML models in improving irrigation water quality assessment, providing valuable insights for groundwater-based crop management.
Quantificação de fenóis, flavonoides totais e atividades farmacológicas de geoprópolis produzida pela abelha Plebeia aff. flavocincta no semiárido do Rio Grande do Norte
Authors:   , Silva Jardel Bezerra da
Published: January 2025

O estudo objetivou avaliar a geoprópolis de abelhas Plebeia aff. flavocincta produzida no Rio Grande do Norte-Brasil , através do estudo das atividades farmacológicas, características sensoriais e requisitos físico-químicos. Investigou-se a atividade antioxidante através do método DPPH (2,2-difenil-1-picril-hidrazilo), antibacteriana, através do método de difusão em ágar e atividades cicatrizantes, através da indução de feridas cirúrgicas experimentais em Rattus norvegicus Berkenhout, 1769, linhagem Wistar. Quantificou-se os teores de fenóis e flavonoides totais através dos métodos Waterman e Mole, Woisky e Salatino, respectivamente. As amostras de geoprópolis apresentaram consistência entre maleável pegajoso a rígido resinoso e nos extratos hidroalcoólicos de geoprópolis identificou-se 06 distintos tipos de aroma, coloração âmbar, marrom escuro, esverdeado e incolor. O sabor variou do amargo ao característico forte e adocicado. Todas as amostras dos extratos apresentaram-se com aspecto líquido, límpido e homogêneo. O teor de fenóis totais variou entre 0,00± 0,00 e 9,4± 0,28% (m/m), o teor de flavonoides totais 0,0005 ± 0,00003 e 0,0220 ± 0,00037% (m/m). A capacidade antioxidante acima de 90% foi observada em 05 amostras. Os extratos foram considerados eficazes no que tange a atividade antimicrobiana, pois das 08 amostras testadas, 05 promoveram halos de inibição ≥9mm frente todas às cepas testadas. No ensaio de cicatrização do grupo experimental, o creme base 20% de geoprópolis de P. aff. flavocincta diminuiu os sinais de inflamação e estimulou a produção de colágeno, acelerando o processo de re-epitelização, apresentando diferença estatística significativa nas áreas das feridas a partir do 9° dia e total cicatrização no 16° dia. Conclui-se que a geoprópolis da P. aff. flavocincta produzidas no semiárido do RN, pode ser usada como princípio alternativo e natural nas atividades antibacteriana, cicatrizante e antioxidante, caracterizando por ser fonte de compostos fenólicos.
Avaliação Nutricional das folhas de Moringa oleífera para aves
Authors:   , Marinho Jéssica Berly Moreira
Published: January 2025

As folhas de Moringa oleífera são consideradas um alimento promissor para
região nordeste, devido ao seu perfil nutricional e sua capacidade de ser manter verde
durante os períodos de estiagem. Diante disso, objetivou-se avaliar a composição físicoquímica
e a digestibilidade e o valor energético das folhas de moringa desidratadas para
aves. As análises bromatológicas foram realizadas quanto aos teores de proteína bruta,
matéria seca, extrato etéreo, fibra em detergente neutro e fibra em detergente ácido, cinzas
e energia bruta pelo método convencional e pelo método de espectrometria próxima de
infravermelho. Além da quantificação de clorofila a e principais compostos bioativos
como: antocianinas, caratenoides totais, flavonoides amarelos, polifenóis extraíveis totais
e vitamina C, através do método de espectrometria. Os resultados da composição das
folhas desidratadas da moringa mostraram que a mesma apresenta bons teores de proteína
bruta (30,93%) para análises convencionais e para análises no NIRS (31,64%)
antocianinas (1,02 mg/100g), carotenoides totais (1,48 mg/kg), clorofila a (120,62
mg/kg), flavonoides amarelos (25,76 mg/100g), polifenóis (105,15 mg/100g) ,
destacando-se a quantidade de vitamina C (485,71 mg/100g). No ensaio de
digestibilidade, 20 aves adultas foram alojadas individualmente em gaiolas metálicas
adaptadas para coleta total de excretas, com cinco tratamentos (0, 5, 10, 15 e 20% de
inclusão das folhas de moringa), distribuídas em delineamento inteiramente casualizado.
Para coeficientes de digestibilidade aparente das rações com níveis crescentes de inclusão
de folhas desidratadas de Moringa oleífera, foi observado um efeito linear decrescente
para matéria mineral (MM) ), y= 27,3120 – 0,4934x, (R2 = 0,65), extrato etéreo (EE), y=
87,3124 – 0,9394x, (R2 = 0,72); fibra em detergente neutro (FDN), y= 29,6686 - 0,2957x,
(R2 = 0,61); fibra em detergente ácido (FDA), y= 20,2322 – 0,1688x, (R2 = 0,68); para o
coeficiente de metabolização de energia bruta (EB), y= 72,4564 – 0,4285x, (R2 = 0,77) e
para energia metabolizável aparente das rações (EMA) y= 3783,96 – 15,52x, (R2 = 0,29).
Com exeção da matéria seca (MS) e da proteína bruta (PB),que não observados efeitos
significativos. O valor de energia metabolizável aparente das folhas de moringa para aves
adultas foi de 2.155,81kcal/kg, valor este obtido através da técnica de Matterson. Também
foi observado o coeficiente de metabolização de energia (CME) com 47,44 % para folha
de moringa.
Imunolocalização de receptores de leptina no ovário de preás (Galea spixii Wagler, 1831)
Authors:   , Macêdo Luã Barbalho de
Published: January 2025

A leptina, uma citocina produzida pelas células adiposas, possui ação na reprodução dos animais promovendo a puberdade, foliculogênese e oogênese, ciclo estral e auxiliando na fecundação. A compreensão dos mecanismos que controlam a atividade reprodutiva de preás (Galea spixii) possui papel relevante para a preservação da espécie. Desta forma, o presente trabalho propôs analisar a imunolocalização dos receptores de leptina (Ob-R) no ovário de preás. Coletaram-se os ovários de 20 fêmeas adultas, não prenhes e saudáveis. As amostras foram fixadas em paraformaldeído a 4% em tampão fosfato, incluídas em parafina e seccionadas para a realização de imunohistoquímica. As secções foram fotomicrografadas e avaliadas quanto à intensidade da reação. Observou-se forte imunorreação no oócito e nas células da teca, moderada nas células do estroma ovariano e nas células luteínicas grandes e fracamente coradas nas células da granulosa, endoteliais, perivasculares e células luteínicas pequenas. Quando comparado a expressão de receptores ao longo do desenvolvimento folicular foi observado que o oócito e as células da teca se mantiveram com expressão na mesma intensidade. Entretanto, as células da granulosa apresentaram forte marcação nos estádios pré-antrais enquanto que nos folículos antrais apresentou fraca intensidade. Concluímos que em ovários de Galea spixii existe a presença de Ob-R nas principais estruturas do ovário sugerindo que este hormônio desempenhe papel fundamental na reprodução desta espécie.
Vitrificação e cultivo in vivo de tecido ovariano de cutias (Dasyprocta leporina, Lichtenstein, 1823)
Authors:   , Praxedes Erica Camila Gurgel
Published: January 2025

O objetivo do presente estudo foi utilizar a manipulação de oócitos inclusos em folículos ovarianos pré antrais (MOIFOPA) como ferramenta para o resgate e conservação do uso de gametas femininos de cutias (Dasyprocta leporina). A dissertação foi dividida em duas fases experimentais. Na primeira, foi realizada a vitrificação em superfície sólida (SSV) utilizando diferentes concentrações de agentes crioprotetores (ACPs), na qual foram verificados os efeitos das concentrações de 3 e 6 M de dimetilsufoxido (DMSO) e etilenoglicol (EG), bem como a associação de ambos os ACPs na concentração maior (6 M) sob a morfologia, viabilidade e apoptose celular de folículos ovarianos pré-antrais in situ (FOPAs). Um total de 865 FOPAs foi analisado antes e após a vitrificação. No grupo controle, foi observado 80,7 ± 5,21% de FOPA morfologicamente normais. Após SSV, independentemente do ACP utilizado, foram obtidos até 76,7% ± 5,4 de FOPAS. Na análise de viabilidade, DMSO 3 M, DMSO 6 M, EG 3, EG 6 M (70,0%; 81,11%; 76,6% e 71,11%; respectivamente) apresentaram valores semelhantes de FOPAS viáveis ao grupo controle (79,0%). Na segunda fase, foi realizada a SSV utilizando a associação dos ACPs (DMSO e EG), seguido do xenotransplante de tecido ovariano de cutias em camundongas C57Bl/6 SCID. Através do monitoramento do lavado vaginal, observou-se que 80% das camundongas do grupo controle e 42% do grupo vitrificado retornaram à atividade ovariana, confirmada pela dosagem hormonal. Microscopicamente, folículos primordiais, primários, transição e secundários foram observados nos enxertos, e todos tinham morfologia normal para as espécies estudadas. No entanto, os folículos primordiais e primários foram observados em maior quantidade após transplante. As Regiões organizadoras de nucléolos (NORs) revelaram que após o transplante ocorreu uma redução significativa de NORs no grupo vitrificado-xenotranplantado (1,66 ± 0,25) quando comparados aos grupos controles (grupo controle fresco: 7,19 ± 1,23; grupo controle xenotransplantado: 9,10 ± 0,64). As células apoptóticas (TUNEL positivo) foram encontradas somente após o transplante das amostras vitrificadas e folículos saudáveis foram encontrados nos outros grupos tratado (TUNEL negativo). Assim, como conclusão geral, o uso da MOIFOPA em cutias permitiu o conhecimento de aspectos relacionados a sua morfofisiologia reprodutiva, possibilitando tanto a conservação do material genético, com a possibilidade de formação de bancos de germoplasma; e ainda a elucidação dos mecanismos relacionados à sobrevivência e ao desenvolvimento dos FOPA in vivo.
Biosimilar Denosumab in Osteoporotic Patients Attending a Tertiary Care Hospital of Eastern India: A Real-world Comparative Retrospective Observational Study
Authors: Bandyopadhyay Syamasis , Dastidar Aheli Ghosh , Chandra Sandip , Dutta Aloke , Samanta Rajeswar , Singhal Parineeta , Sengupta Swagatam , Ganguly Supratim
Published: January 2025

Background

Denosumab, a monoclonal antibody directed against RANK-Ligand, inhibits the formation, function, and survival of osteoclasts, leading to the inhibition of bone resorption, resulting in increased bone mass and prevention of fractures. Despite the availability of biosimilar denosumab in India for more than 5 years, Real-world Evidence (RWE) on the control of disease severity, tolerability, and safety of these biosimilars is lacking.

Objectives

This analysis is intended to compare the in-clinic effectiveness and safety of the Indian drug authority-approved denosumab biosimilar (Intas-Pharma) with the innovator denosumab.

Methods

Data of osteoporotic patients receiving either innovator denosumab or biosimilar denosumab (60mg SC every 6 months) for 2 years in routine clinical practice as per patient choice were evaluated. Effectiveness was measured based on the change in Lumbar spine (LS-TS) and Total Hip T scores (HIP-TS). Student t-test was carried out to evaluate intragroup change in T-scores at both sites and compare inter-group T-scores at baseline, as well as after 2 years of denosumab treatment at both sites. Adverse events reported in both groups were noted.

Results

A total of 49 osteoporotic patients receiving denosumab (n=28 biosimilar denosumab, n=21 innovator denosumab) were evaluated. All patients received concomitant vitamin D and calcium throughout the study duration.

The mean LS-TS values for the innovator and biosimilar groups at baseline were -3.85±0.20 and -3.82±0.21, respectively, while the mean HIP-TS values for the innovator and biosimilar group at baseline were -3.60±0.22 and -3.57±0.21, respectively. Both groups were comparable at baseline, and there was no significant difference between the two groups in terms of T scores at both sites. After 2 years of denosumab treatment, mean LS-TS values for the innovator and biosimilar groups reached -2.82±0.26 and -2.74±0.25, respectively, while the mean HIP-TS values for the innovator and biosimilar group were recorded to be -2.41±0.27 and -2.40±0.24, respectively. When post-treatment T scores were compared, there was no significant difference between the two groups at any of the sites.

When an intra-group change in T scores from baseline over 2 years was evaluated, both innovator and biosimilar denosumab groups were observed to have significant improvement (p<0.0001) in mean LS-TS as well as HIP-TS values. No severe adverse effects were noted in any group, and the safety profile of both groups was comparable.

Conclusion

Biosimilar denosumab was found to be as effective as innovator denosumab in increasing bone mineral density at the lumbar spine as well as total hip among osteoporotic patients attending Indian rheumatology clinics.
Neglecting Laws and Rights of Local Communities: A Human Rights-Based Approach Analysis of the Development of Indonesia’s New Capital City
Authors: Marzuki Suparman , Heryansyah Despan , Hadi Sahid
Published: January 2025

It is reported that the development of Nusantara as Indonesia’s new capital city tends to be pragmatic and disregards the quality of its processes and outcomes. Such a development has reduced the public’s trust, mainly because of this project’s environmental loss, social-humanity problems, and economic challenges. By employing human rights-based approaches to development, this article discusses the implementation and policy issues of the development of Nusantara in more depth and detail based on the rights holders’ experiences living in the Nusantara and its neighbouring areas. The research reveals that the development of Nusantara, ranging from its planning and policy formulation to its implementation, clearly neglected applicable laws and regulations. It failed to respect the rights of local communities, including indigenous peoples who enjoy their livelihoods in Nusantara and its neighbouring areas. We argue that the lack of respect and protection of human rights in the development implementation is because the development policy of Nusantara is grounded in autocratic legalism, even if it is established in a democratic mechanism.
Technology-enhanced learning in higher education institutions in Malaysia
Authors:   Faculty of Languages and Communication, Sultan Idris Education University, Tanjung Malim, Malaysia, Muniisvaran K. , Jose Franklin Thambi ,   Faculty of Languages and Communication, Sultan Idris Education University, Tanjung Malim, Malaysia, Kartheges P. ,   Faculty of Languages and Communication, Sultan Idris Education University, Tanjung Malim, Malaysia, Anusia K. ,   Faculty of Languages and Communication, Sultan Idris Education University, Tanjung Malim, Malaysia
Published: January 2025

Technology has become a dominant force worldwide, influencing various fields, including education. The adoption of technologies such as artificial intelligence (AI) and digital tools has transformed teaching and learning practices, especially after the pandemic. In higher education, both instructors and students have embraced technology-based learning methods. Technology-enhanced learning aims to maintain learners' attention and engagement through active learning strategies. This study aims to assess the impact of technology-enhanced learning in higher education institutions in Malaysia, highlighting its strengths and weaknesses. A blended research approach was used, combining both quantitative and qualitative methods. Data were collected from 425 students across five higher education institutions using questionnaires as the primary research tool. The findings show that the use of smart devices in technology-enhanced learning has increased, making the learning process easier for students. The study also identifies the strengths and weaknesses of technology-enhanced learning and provides recommendations for addressing its limitations.
Exploring Post-Quantum Cryptography: Evaluating Algorithm Resilience against Global Quantum Threats
Authors: Al Attar Tara Nawzad Ahmad , Mohammed Mohammed Anwar , Mohammed Rebaz Nawzad
Published: January 2025

Cryptographic algorithms perform a vital part in protecting information in general and safeguarding digital platforms. Nevertheless, improvements in quantum computing pose important concerns to traditional cryptographic approaches, demanding the development of quantum-resistant explanations. This study offers an inclusive investigation of post-quantum cryptographic algorithms, assessing their flexibility, competence, and practicality in justifying quantum risks. Through an equivalent approach, the research identifies optimistic applicants for upcoming cryptographic standards. Moreover, the study highlights the international essential for embracing these algorithms to ensure secure communication and data protection in the quantum era. These conclusions aim to notify the progress of strong cryptographic systems that address the appearing objections of quantum technologies.
The Florida Cohort Wave 3: Recruitment and Data Collection from Persons with HIV in Florida: 2019-2023 (Preprint)
Authors: Fisk-Hoffman Rebecca , Parisi Christina E , Siuluta Nanyangwe , Manavalan Preeti , Bilello Lori A , Cohen Colby , Devieux Jessy , Ibanez Gladys , Kuretski Jennifer , Somboonwit Charurut , Widmeyer Maya , Zhou Zhi , Cook Robert L
Published: January 2025

BACKGROUND

Ending the HIV Epidemic remains a high public health priority, and the state of Florida continues to have high HIV prevalence and incidence.

OBJECTIVE

The Florida Cohort study seeks to identify factors associated with the HIV Care Continuum and HIV-related comorbidities, with a focus on potential impact of alcohol consumption.

METHODS

The Florida Cohort Wave 3 enrolled persons with HIV aged 18+ from nine clinical, case management, and community settings across Florida from 2020 to 2023. All participants completed a baseline questionnaire, and most completed additional questionnaires at baseline and approximately one year after baseline. Data on HIV care and treatment, mental health, substance use, stigma, and technology were collected on the baseline questionnaire. Additional questionnaires covered alcohol use, gender identity, COVID-19, pets, stigma and discrimination, and antiretroviral therapy (ART) preferences. Questionnaire data were securely linked to HIV Care Continuum variables from Florida’s state HIV monitoring system.

RESULTS

Overall, the study enrolled 836 PWH (56% non-Hispanic Black, 16% Hispanic, 57% assigned male at birth, and 58% aged 50+). Most (97%) participants were linked to the state HIV reporting system and will be followed for up to five years to monitor HIV outcomes. Thirty-one participants completed the gender identity questionnaire, 230 completed the alcohol questionnaire, 287 completed the COVID-19 questionnaire, 221 completed the pet questionnaire, 461 complete the stigma and discrimination questionnaire, and 210 completed the ART preference questionnaire.

CONCLUSIONS

The study provides opportunities to monitor changes in HIV-related outcomes as well as relevant attitudes, behaviors, and healthcare preferences, but has some limitations in terms of representativeness and tracking of longitudinal outcomes.
Development of a novel web-based intervention targeting pain-related outcomes in chronic orofacial pain: Protocol for a mixed methods study (Preprint)
Authors: Lovette Brenda C. , Bakhshaie Jafar , Kulich Ronald , Shaefer Jeffry R. , Cheng Hsinlin Thomas , He Shuhan , Vranceanu Ana-Maria , Greenberg Jonathan
Published: January 2025

BACKGROUND

Chronic orofacial pain (COP) is common, costly, and associated with substantial pain interference and emotional distress. Psychosocial treatments for COP are scarce and limited (e.g., relying on talking, which is often painful for this population; requiring intensive resources limiting scalability). Here, we describe the study protocol for developing Face-Forward-Web, a web-based, “talk-free” mind-body intervention for patients with COP. We aim to: 1) develop Face-Forward-Web with the aid of live-video focus groups with adults with COP; and 2) optimize Face-Forward-Web and our study protocol through beta testing followed by an open pilot feasibility trial.

OBJECTIVE

We aim to: 1) develop Face-Forward-Web with the aid of live-video focus groups with adults with COP; and 2) optimize Face-Forward-Web and our study protocol through beta testing followed by an open pilot feasibility trial.

METHODS

We will accomplish these aims with two phases, incorporating user-centered design principles. For Phase 1, we are conducting semi-structured focus groups (N=4-5 groups, 20 patients or until thematic saturation) with individuals with COP. We are using Rapid Data Analysis followed by thematic analysis to gauge treatment needs, preferences, and perceptions of the proposed platform and skills. This information will inform session structure and content, as well as development of a wireframe followed by a prototype. For Phase 2, we will conduct beta testing (up to n=10) followed by an open pilot (up to n=20) with exit interviews to gather feedback. Primary outcomes are feasibility such as recruitment (≥70% of eligible participants will participate), acceptability (≥70% of participants complete ≥ 4/5 sessions), credibility, expectancy (≥70% above the Credibility and Expectancy scale’s mid-point), and satisfaction (≥70% above the User Experience Questionnaire’s mid-point). We will also explore preliminary improvements in outcomes (pain interference, emotional distress) and mechanistic targets (pain catastrophizing, fear of pain, mindfulness).

RESULTS

The trial is ongoing.

CONCLUSIONS

Face-forward-Web will be the first “talk-free” web-based intervention tailored for the needs of adults with COP. Results will inform a future efficacy trial.
Global Trends in Cadaver Donation and Medical Education Research:A Bibliometric Analysis Based on VOSviewer and CiteSpace (Preprint)
Authors: Zhou Xianxian , Xiong Hua , Wen Yi , Li Fang , Hu Dexi
Published: January 2025

BACKGROUND

The cadaver serves as a crucial resource in medical education, research, and clinical practice, as well as a vital foundation for fundamental medical experimental teaching.

OBJECTIVE

This study aims to employ bibliometric analysis to create a knowledge map of cadaver donation in medical education, identify global trends, anticipate future research directions, and offer a foundation for upcoming investigations.

METHODS

Articles and review papers concerning cadaver donation and medical education, with a final search cutoff of January 10, 2025, were systematically retrieved from the Web of Science Core Collection database. Two reviewers carefully examined the initial set of articles based on titles and abstracts to exclude irrelevant ones. The selected publications were then analyzed and visualized for country, institution, author, reference, journal, and keywords using CiteSpace 6.3R3, VOSviewer 1.6.19, and the Online Analysis Platform of the Literature Metrology Database.

RESULTS

Our analysis shows a steady rise in the total number of publications, with a significant spike after 2020, reaching its peak in 2024. The United States was a major contributor, accounting for 21.2% (303/1114) of all publications, while McGill University and The University of Sydney were the leading institutions. Prominent authors in this field included De Caro Raffaele, Macchi Veronica, Porzionato Andrea, Stecco Carla, and Dhanani Sonny. The most frequently co-cited reference was "Bodies for Anatomy Education in Medical Schools: An Overview of the Sources of Cadavers Worldwide." The journal Anatomical Sciences Education published the most articles in this area and received the highest citation count. Cluster analysis of keywords revealed that "kidney transplantation," "gross anatomy education," and "brain death" were key research topics, while burst analysis of keywords identified "public perception" and "anatomical science" as emerging areas of investigation.

CONCLUSIONS

The study underscores the dynamic progress of cadaver donation research and global cooperation, focusing on important countries, institutions, authors, and journals. These elements are pivotal in driving the development of cadaver donation and shaping the direction of future research in medical education. Future studies should prioritize increasing public awareness of cadaver donation to further foster the expansion of medical education.
Studies on the Loading and Release of Metformin HCl Using Hydrogels with EGDMA and MBA as Crosslinkers
Authors: Ariyaldi Ariyaldi , Nizardo Noverra Mardhatillah , Lestari Maria Lucia Ardhani Dwi
Published: January 2025

Hydrogel poly(N-vinylcaprolactam-co-2-(dimethylamino)ethylmethacrylate) or (P(NVCL-co-DMAEMA)) containing the active drug metformin HCl were synthesized using the free radical polymerization method in the presence of DMAEMA and NVCL monomers by using two different crosslinkers: ethylene glycol dimethacrylate (EGDMA) and methylene bisacrylamide (MBA). FTIR spectra confirmed the successful formation of hydrogel and its loading with metformin HCl. SEM analysis revealed the physical shape and surface features. Regarding physical appearance, the texture of the hydrogel is sticky and elastic. When the hydrogel was immersed in a solution, it swelled, and returned to its original shape after drying. Additionally, the chemical degradation temperature is thermally stable at 329.75 °C. The loading test results showed that the active drug in EGDMA was 18.38 (% w/w) and 26.19 (% w/w) in MBA as crosslinkers, loaded within 24 h. The drug-loaded hydrogel containing EGDMA as crosslinkers in pH 7.4 had the highest drug release in 24 h compared to MBA. Then, the drug released from hydrogel with EGDMA in pH 2 had the highest drug release than MBA within 30 min. The P(NVCL-co-DMAEMA) hydrogel has the potential for a drug delivery system. However, additional optimizations are necessary to improve the efficiency of the hydrogels as a carrier.
Sulfasalazine as a Corrosion Inhibitor on Carbon Steel Metal Surfaces in Acidic Media Using the Hydrogen Evolution Method: Experimental and Theoretical Studies
Authors: Obaid Hadi Thamer , Mutar Muthanna Mahmood , Ali Safaa Hussein
Published: January 2025

Current study designed to explore the anti-corrosion effect of 2-hydroxy-5-{(E)-[4-(pyridin-2ylsulfamoyl)phenyl]diazenyl} benzoic acid (sulfasalazine, SSZ) on carbon steel. 1 M of HCl solution used as an aggressive medium. The corrosion process was significantly inhibited by SSZ using simple, direct and accurate method (hydrogen evolution) to measure corrosion inhibition process. The results showed that the corrosion inhibition efficiency increased with increasing the inhibitor SSZ concentration. Three different concentrations of the inhibitor SSZ (0.1 × 10−3, 0.5 × 10−3, and 1.0 × 10−3 M) were used in the corrosion experiment. Results showed a maximum inhibition efficiency (89.74%) achieved at the concentration of 1 × 10−3 M and the temperature of 308 K. The calculations of the hydrogen evolution method showed that the investigated SSZ acted as a mixed-type inhibitor. Adsorption of SSZ on the carbon steel surface obeys the Langmuir adsorption isotherm. The quantitative chemical parameters were calculated using density functional theory (DFT). In addition, full geometry optimizations were performed using DFT with B3LYP. The correlation between the theoretical and experimental results is discussed. The theoretical and experimental studies showed that SSZ is a good inhibitor as the maximum anti-corrosion activity was achieved at the highest concentration of the SSZ (1 × 10−3 M), and the lowest temperature used in the experiment.
Optimization of Protein Hydrolysate from Earthworms (Perionyx excavatus) of Angiotensin-I-Converting Enzyme Inhibitory Activity by One Variable at a Time
Authors: Bui Phong Thanh , Hoang Truc Anh , Pham My Thi Thuy , Tran Linh Le Phuong , Nguyen Oanh Kim
Published: January 2025

Hypertension, characterized by elevated blood pressure, is commonly treated with angiotensin-I-converting enzyme (ACE) inhibitors. This study evaluated the ACE inhibitory activity (ACEIA) of protein hydrolysate from earthworms (Perionyx excavatus) by commercial proteases. The results showed that the protein hydrolysate of earthworms gave the highest ACEIA of 85.38 ± 2.31% (at the protein concentration of 2 mg/mL) and IC50 value of 844.64 μg/mL when the earthworms were hydrolyzed with Flavourzyme® 500 MG under optimized conditions such as earthworm:phosphate buffer ratio of 1:6 (w/v), hydrolysis temperature of 50 °C, pH 7, enzyme:substrate ratio of 600 U/g protein and hydrolysis time of 2 h. The membrane further fractionated the hydrolysate, and the < 1 kDa fraction had the highest ACEIA with an IC50 value of 261.94 μg/mL. The stability of ACEIA was assessed under various conditions, including in vitro digestion, heat treatment at 100 °C for 180 min, and pH adjustments from pH 1 to 11. The < 1 kDa fraction maintained ACEIA activity at 133.34, 76.25, and 84.95%, respectively, after these treatments. These results suggest that earthworm protein hydrolysates, particularly the <1 kDa fraction, exhibit strong stability and could be promising candidates for the development of functional foods or pharmaceuticals targeting hypertension.
‘Caucasian Tatar’ as Lingua Franca for a Russian Translator: Linguistic Studies and Teaching Activities of Timofey N. Makarov
Authors:   Southern Federal University, Bedrik Andrei V. , Kovtunenko Inna V. ,   Southern Federal University, Kudryashov Igor A. ,   Southern Federal University, Peretyatko Artyom Y. ,   Southern Federal University
Published: January 2025

Introduction. The article attempts a comprehensive reconstruction of one significant historical episode — the consistent shaping of basic grammatical constructs for the universal Caucasian language in scholarly endeavors and pedagogical activities of Timofey N. Makarov. The original linguist would undertake his efforts in various sociocultural contexts, including Oriental Languages Department of Novocherkassk Gymnasium. T. Makarov’s legacy never received unambiguous assessments in the previous historiographic tradition, which was determined by a variety of factors (including those of opportunistic nature). Materials and methods. The to-be-introduced empirical material is reconstructed on the basis of documents contained in Collection 358 (‘Public Schools Directorate of Don Host Oblast’) at the State Archive of Rostov Oblast. In terms of methodology, the study rests on principles of microhistorical heuristics to be verified within a comparative reconstruction of intellectual plots (episodes) in a specified sociocultural context. Results and conclusions. T. Makarov considered ‘Caucasian Tatar’ to be the main language of the Caucasus serving as lingua franca for diverse highland communities. The original linguist would examine the artificial unification of dissimilar dialects by a geographical principle as a full-fledged linguistic construct with individual dialects be unconditionally understood in any point of the specified territory. Having been focused on practical training of professional translators, T. Makarov’s would maintain essentially instrumental attitudes to ‘Caucasian Tatar’. The Russian expert tended to underestimate significant differences between individual dialects, and insisted that full proficiency in one of the latter did make it possible to teach others characterized by similar lexical constructs.
Central Muslim Spiritual Directorate of the RSFSR: From the 1923 Congress to the 1948 Forum
Authors: Akhmadullin Vyacheslav A.
Published: January 2025

Financial University under the Government of the Russian Federation
Situated Design
Authors: Agudin Catalina Lucía , Trillo Joaquín
Published: January 2025

The transfer of typologies, technologies and materials promoted by development programmes does not usually take into account the solutions of form and function with which the indigenous communities of Central Chaco give meaning to their architecture. The contents and designs promoted from a centralized management of decisions are implemented by agencies with the capacity to influence policies that are unaware of the local conditions and the trajectories of the peoples on which they have an impact. On the other hand, it will be shown how design education in Argentina focuses on other issues. From different theoretical guidelines of Latin American critical thought, the need to decolonize the principles of modernity towards alternatives where the point of origin is to be found in subaltern knowledge will be raised. Within this framework, the work explores the logics of the social construction of habitat through participatory design processes that allow the communities to be elevated as actors with their own voice and capacity to design programmes with local identity, through action research projects in the indigenous territory of Lhaka Honhat in the province of Salta, Argentina.
Dematerializing Riegl’s Modern Cult of Monuments
Authors: Beim Nikola
Published: January 2025

This paper delves into the transformation of memory and heritage in the digital age, interpreting Alois Riegl’s pivotal 1903 work, “The Modern Cult of Monuments,” through the lens of today’s digital technologies. Riegl’s axiological examination, foundational in the field of heritage preservation, is reevaluated to explore how digital documentation reinterprets historical and age values of monuments, aligning with his philosophy of ‘touchless’ preservation. This research proposes a novel paradigm for representing and engaging with monuments within the digital sphere that I term “Cult Beyond the Digital.”
Furthermore, the paper argues for the contemporary relevance of Riegl’s methodologies in architecture, particularly those linked to non-contact recording methods that result in the creation of intangible heritage. The paper speculates on future preservation strategies, especially as emerging AI technologies promise the potential to reconstruct missing historical data and enhance monument preservation efforts.
By examining the interaction between technological advancements and monument preservation, the study revisits and expands Riegl’s theory, offering a forward-looking perspective on the discipline in the digital and beyond the digital era, aligning with the theme “Beyond the Visible” by exploring how architectural processes such as aging are documented by contemporary digital tools to protect our heritage and memory. This invisible force of time leaves architecture with traces that can be seen as a continuous “unmaking” or dematerializing of its physical forms. The age value of monuments was considered the monument’s most essential value of the twentieth century, according to Riegl. Extending his theory to our time, the age value is surpassed by what I call a “timeless” value that represents digitally documented monuments over time. They, as digital data, shift their properties from the material world to the digital realm. By doing so, the main protagonist of this architectural “unmaking” is not an architect but the environment itself.
Comprehensive Deep Learning Framework of Image, Audio and Video Forgery Detection
Authors: Indore Prerana
Published: January 2025

With the rapid rise of digital media, the potential for forgery in images, audio, and video has grown significantly,
posing threats to areas such as journalism, law enforcement, and social media. Image forgeries such as splicing, copy-move,
and retouching, audio manipulations such as splicing and voice cloning, and video forgeries including deepfakes and frame
tampering, have become prevalent. The detection of these forgeries is a critical challenge due to the sophistication of editing
tools and AI-based generation techniques. This paper presents a comprehensive deep learning-based framework for detecting
forgeries across all three media types: image, audio, and video. We utilize specialized convolutional and recurrent neural
network models designed for each medium, incorporating advanced preprocessing and feature extraction techniques. The
proposed framework demonstrates high accuracy in detecting forgeries by utilizing publicly available benchmark datasets for
training and validation. Our results show promising performance, achieving high precision and recall metrics across all
media types, highlighting the robustness of the system in real-world scenarios.
Advanced Footstep Power Generation using RFIDs
Authors: Khandare Prof. J. R.
Published: January 2025

In today's world, the demand for renewable energy is ever-increasing. Footstep power generation offers a sustainable
and innovative approach to energy harvesting. By leveraging piezoelectric technology and integrating RFID modules, this system
aims to generate electrical power efficiently and enable user identification for personalized energy contribution tracking. The
energy harvested is stored in batteries or super capacitors and can be used for various applications, such as lighting, IoT
systems, and smart infrastructure in urban areas.
Multi-Source Maximum Relation Mapping of Sentiments and Events Based Multi-Agent Deep Reinforcement Learning for Stock Price Trend Forecasting
Authors: C Dr. Bhuvaneshwari
Published: January 2025

Forecasting of future stock price variations in the ever fluctuating stock exchanges has attracted greater interest from
all fields because of its prominent role in the economy building of a nation. Traditional forecasting models relied on single
source data for price prediction while the recent research has inclined towards the multi-source data for more reliable
forecasting model. Recent studies extracted stock related events and public opinions from different sources as indicators for
future stock price forecasting and have resulted in effective forecasting models. In this paper, a novel Maximum Relation
Mapping Multi-Agent Deep Reinforcement Learning (MRMMA-DRL) model has been developed for efficient stock price
forecasting. The novelty of this model is that it extracts multiple indicators from public tweets and news events through
maximum relation mapping to enhance the interrelation among them. These interrelated indicators for stock price were
extracted using Deep Weighted Extreme Learning Machine (DWELM) and Convolutional Deep Restricted Boltzmann Machine
(CDRBM). Maximum relation mapped sentiments extracted by DWELM and events extracted from CDRBM which are used
learning for stock price fluctuations. The stock forecasting results obtained by this novel forecasting model are highly reliable
and accurate due to the interrelated indicators. Real-time datasets collected from Twitter, News website and Stock exchange for
12 months period is used for evaluation. The results highlight the efficiency of the MRMMA-DRL model which achieved
promising results of 96.67% accuracy and minimized time complexity.
CredBud: The Ultimate Student Platform
Authors: Shinde Prof. Vidya
Published: January 2025

In the rapidly evolving educational landscape, effective management of student performance, attendance, and
engagement is essential for fostering accountability, motivation, and academic growth. Addressing the limitations of traditional
methods, CredBud introduces an innovative digital platform designed to revolutionize academic management. This secure, userfriendly ecosystem empowers both students and faculty to enhance efficiency and collaboration. CredBud’s key features include
a credit allocation and grading system to monitor academic progress, a theoretical points mechanism to encourage active
participation, and a customizable rewards framework tailored to individual student preferences. The platform incorporates realtime attendance tracking powered by QR code technology, minimizing administrative errors, streamlining processes, and
ensuring data accuracy. By allocating points for attendance, CredBud not only incentivizes consistent participation but also
fosters a culture of accountability and recognition. Beyond attendance management, CredBud supports assignment verification,
grade sheet generation, and token-based incentives to boost academic performance and administrative efficiency. It also
consolidates certifications, project records, and other achievements into a centralized repository, simplifying the process of
showcasing academic milestones. Designed to meet the dynamic needs of educational institutions, CredBud operates seamlessly
across Android, iOS, and web platforms, ensuring broad accessibility and inclusivity. Its iterative development approach
emphasizes simplicity, scalability, and robust security, enabling the platform to adapt to emerging educational demands. By
integrating cutting-edge technologies and fostering a culture of recognition, motivation, and continuous improvement, CredBud
sets a new benchmark for educational engagement and management, redefining academic success for the future.
Mental Health and work-life Balance among Workers in Social Services
Authors: Buzzalova S. , Vansac P. , Tomanek P. , Rottermund J.
Published: January 2025

Objective: This study investigates the relationship between
burnout, overtime work, and psychological resilience in social
workers in social care centres. The wellbeing of individuals in
helping professions, notably social workers in care services,
decreased by 15% last two years. Mental health declined
by 23.4%, and 36.2% of workers reported increased mental
stress.
Methods: A quantitative cross-sectional study was conducted
in 2024 on a sample of 156 social workers. Data were collected using validated instruments assessing burnout, mental
stress, resilience, and life satisfaction. Statistical analysis was
performed to examine the correlations between burnout levels, overtime hours, and resilience factors, using p-values to
assess significance.Results: Burnout was found to be at 30% among social workers, with a direct correlation to overtime hours, averaging
5-8 hours per week during the pandemic. Workers with higher resilience showed better self-confidence, adaptability, and
problem-solving abilities. Resilience was strongly linked to
self-acceptance, self-esteem, empathy, and social security.
Additionally, the pandemic negatively impacted autonomy
(p=0.024), self-acceptance (p=0.016), and purpose in life
(p=0.037), as measured by life satisfaction scales. Burnout
symptoms were reported by 20% of social workers and 11.5%
of caregivers, with caregivers showing a higher burnout rate
(33.4%) compared to social workers (31.3%).
Discussion: The findings highlight the critical role of psychological resilience in managing the emotional demands of social work during crises like the COVID-19 pandemic. Higher
resilience is associated with improved coping mechanisms and
professional growth, while low resilience correlates with increased burnout and difficulties in client management. Workload, financial status, and lack of rest were key predictors of
life dissatisfaction, emphasizing the need for systemic interventions to support workers’ mental health and reduce burnout.
Conclusion: The COVID-19 pandemic has exacerbated burnout and reduced wellbeing among social workers and caregivers. Enhancing psychological resilience through targeted interventions may help mitigate these effects and improve their
capacity to adapt to future stressors. Addressing workload
management and providing mental health support are crucial
for sustaining professional efficacy in social care services.
Marketplaces as Drivers of Urbanization and alternative Governance Spaces: the Case of Batkhela Bazaar, Pakistan
Authors: Salman Khan M , Naz A.
Published: January 2025

Urbanization in Pakistan is constantly on the rise, both in the
form of migration from rural to urban areas and emergence
of new urban spaces amid the hart of once agrarian village
economies. This paper seeks to examine the latter phenomenon and argues that lack of state’s capacity gives rise to new
political spaces in these rapidly developing towns in Pakistan.
The central premise of this argument is that marketplaces
are one such space that has significant implications for local
political economy. On one hand, this economic change has
implications for traditional political structures based on political exclusivity, while on the other hand, due to increased
significance of marketplaces for local governance, the patterns
of elite interaction and local administration have also evolved
that reflect change in the local governance structure. While
reflecting on my case-study of Batkhela bazaar, I highlight some of the political and governance challenges which these
rapidly growing, unplanned urban spaces might present in the
future. In doing so, this paper contributes to the literature on
transforming rural economies and emerging urban spaces in
the form of small towns in Pakistan.
Pumps and Continuous Glucose Monitoring in Children with Diabetes
Authors: Wong Jenise C. , Capodanno Gina , Adi Saleh
Published: January 2025

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Physical Activity, Sport, and Recreation with Insulin Pumps and Continuous Glucose Monitoring
Authors: Colberg Sheri R. , Scheiner Gary
Published: January 2025

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Practical Use of Insulin Pumps and Continuous Glucose Monitoring in the Hospital
Authors: Kulasa Kristen , Juang Patricia , Rushakoff Robert J.
Published: January 2025

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Benefits of Continuous Glucose Monitoring: A Case of Burnout
Authors: Valencia Adriana
Published: January 2025

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