bluuebunny/crossref_metadata_2025 huggingface dataset:
Variaciones de la intensidad en el Sol desde el centro hasta el limbo u oscurecimiento del limbo solar
Authors: Rodríguez Gómez Jenny Marcela
Published: February 2022

Las variaciones de la intensidad solar del centro al limbo solar son conocidas en Inglés cómo Center to Limb Variations (CLV) u oscurecimiento del limbo solar. Estas permiten caracterizar diferentes capas de la atmósfera solar, específicamente cuándo dichas variaciones se calculan usando diferentes longitudes de onda. Además, estas variaciones permiten obtener información sobre algunas características propias de las imágenes observadas desde telescopios terrestres que observan continuamente el Sol, como su calidad y cómo mejorar está a través de ajustes a los perfiles de variación de la intensidad. También se presenta una breve descripción de cómo las variaciones en la intensidad del centro al limbo pueden ayudar a describir la atmósfera de otras estrellas binarias eclipsantes y aquellas que poseen exoplanetas.
Resenha – O fim das certezas – tempo, caos e as leis da natureza de Ilya Prigogine
Authors: Silva Saulo Luis Lima da , Fumiã Herman Fialho
Published: February 2022

Neste trabalho, apresentamos a resenha do livro O fim das certezas – tempo, caos e as leis da natureza de Ilya Prigogine, publicado em 1996. Prigogine é ganhador do prêmio Nobel de química de 1977 por suas contribuições ao estudo dos sistemas fora do equilíbrio. Não é exagero dizer que esse livro aborda suas principais conclusões sobre esse tema ao longo de um vida dedicada ao assunto. Embora o autor seja muito claro e didático, o tema é extremamente complexo. Alguns capítulos exigirão maior concentração e talvez uma (ou duas) releitura. O esforço é mais do que compensador. O autor nos levará pelas questões mais polêmicas e ainda em aberto na física. Ele não se acanha em discordar dos maiores pensadores da história e faz isso com sobriedade e argumentos sólidos. Podemos resumir a questão central da obra em: passado e futuro são distintos? Já adiantamos que a ingenuidade dessa questão é apenas aparente. A tentativa de responder essa questão faz com que o autor proponha mudanças radicais na visão de mundo apresentada pela física desde Newton. Tais mudanças incluem uma extensão da mecânica clássica e uma formulação unificada da mecânica quântica. Com essa resenha, esperamos auxiliar a leitura dos interessados nessa obra rica, profunda, prazerosa e empolgante.
Avaliação do risco de quedas entre pessoas com doença de Parkinson
Authors: Silva Franciny da , Alvarez Angela Maria , Nunes Simony Fabíola Lopes , Silva Maria Eduarda Massari , Santos Silvia Maria Azevedo Dos
Published: February 2022

RESUMO Objetivo identificar os fatores associados ao risco de quedas entre as pessoas com doença de Parkinson cadastradas na Associação Parkinson Santa Catarina. Método estudo transversal exploratório descritivo e de abordagem quantitativa, realizado com 53 pessoas cadastradas na Associação Parkinson Santa Catarina, no município de Florianópolis, Brasil, no período de junho a setembro de 2019. Foram aplicados questionário sociodemográfico, Escala de Hoehn e Yahr, Mini Exame do Estado Mental e Teste de Rastreio do Risco de Queda no Idoso. Os dados foram tabulados e analisados por meio do Sistema online de Ensino-Aprendizagem de Estatística SEstatNet®. Resultados foram identificados fatores de risco, como sexo, aumento da idade, redução da força muscular, instabilidade postural e diminuição da velocidade da marcha. Em relação aos estágios da doença, foi constatado que em todos houve piora da velocidade da marcha e o medo de cair é constante, aumentando com o agravamento da doença e o tempo de diagnóstico. Conclusão e implicações para a prática ao aprofundar o estudo do tema, o enfermeiro consegue compreender os acometimentos motores que levam à fragilização e à queda em pessoas com doença de Parkinson, elaborando estratégias para preveni-las.
A violência nossa de cada dia
Authors: Minayo Maria Cecília de Souza , Pinto Liana Wernersbach , Silva Cosme Marcelo Furtado Passos da
Published: February 2022

Baseado na Pesquisa Nacional de Saúde de 2019, realizada em consórcio entre o IBGE, o Ministério da Saúde e a Fundação Oswaldo Cruz, este artigo analisa e contextualiza o módulo dedicado a conhecer a violência vivenciada pela população e o impacto sobre sua saúde no ano de 2019. Embora o inquérito sobre saúde tenha abrangido as pessoas de 15 anos ou mais, o módulo sobre violência contemplou apenas as que tinham a partir de 18 anos. Portanto, é começando por essa faixa etária que este trabalho ocorre. Embora o inquérito não tenha designado uma classificação para o conjunto do fenômeno estudado, os autores o nomeiam como vitimização por violência interpessoal, seguindo critérios da Organização Mundial de Saúde. Modelos logísticos foram ajustados a quatro variáveis de desfecho: ter sofrido violência física ou psicológica ou sexual nos últimos 12 meses; ter sofrido violência psicológica nos últimos 12 meses; ter sofrido violência física nos últimos 12 meses; ter sofrido violência sexual nos últimos 12 meses. A prevalência foi de 18,3% de violência física, psicológica e sexual globalmente, bastante mais elevada do que mostra estudo recente realizado a partir de dados de 90 países (8,3%). Por provocar adoecimento e mortes, a violência, além de ser um problema civilizatório é também uma prioridade da área de saúde pública.
Evaluación de la posición condilar y de las vías aéreas en niños con mordida cruzada posterior unilateral antes y después de tratamiento con férula de expansión.
Authors: Rodriguez Manjarres Carolina , Hernández Silva Jesús Alberto
Published: February 2022

Introducción: La mordida cruzada posterior (MCP), debe ser tratada a tiempo para evitar alteraciones estructurales del sistema estomatognático. Su etiología incluye componentes dentales, esqueléticos, musculares y funcionales; puede ser unilateral o bilateral. La expansión rápida maxilar (ERM) es una alternativa de tratamiento para ampliar el arco dental superior y favorecer el desarrollo armónico de la oclusión.

Objetivo: Observar en tomografías computarizadas Cone Beam (TC-CB) los cambios en la posición condilar y aumento en las dimensiones de vías aéreas en niños  antes, durante y después de 6 meses de ERM como alternativa terapéutica para la mordida cruzada posterior unilateral (MCPU).

Metodología: nueve pacientes, 6 a 10 años, con MCPU fueron tratados con ERM por 3 meses y 3 más de retención; Tomografías bimaxilares en máxima intercuspidación pre y pos tratamiento fueron tomadas para evaluar cambios de posición condilar y dimensionales de vías aéreas.

Resultados: El lado cruzado presentó un aumento del espacio anterior de cóndilo, disminución leve de la longitud superior y una marcada disminución de la longitud posterior entre el cóndilo y la fosa glenoidea, evidenciando un desplazamiento posterior y confirmando una posición posterior, después de realizada la ERM. El lado no cruzado presentó el mismo comportamiento. A nivel del volumen de las vías aéreas no se presentaron cambios estadísticamente significativos.

Conclusiones: La ERM es efectiva para el tratamiento de la MCP en dentición mixta ya que cambia la forma del maxilar y genera cambios en la posición condilar; resultados estables en el tiempo que favorecen el desarrollo armónico del complejo craneofacial.
Posthumane Selbstformungen in der Gegenwartsliteratur am Beispiel von Olga Flors Ich in Gelb
Authors: Keil Lisa
Published: February 2022

This article examines the intersections between technologies of the self, posthumanism, and gender by means of a literary analysis of Olga Flor's 2015 novel Ich in Gelb. A reading of the novel shows how Flor discusses the immunotherapy practice of helminthic therapy in connection with different 'monsters' like Medusa, bearded women, and mermaids, motifs that carry certain gender representations. However, the novel not only plays on old representations but also deconstructs traditional gender divisions and dissolves the illusion of a fixed self in employing posthumanist ideas. Applying Haraway's concept of sympoiesis in the analysis of the relationship between human and worm as well as between text and worm, the examination of Flor's novel shows that there is a correspondence between the 'forming' of the self and the literary form of the novel. Therefore, literature has an epistemological function in understanding posthuman technologies of the self.
Delinquency Rates and the "Missing Originations" in the Auto Loan Market
Authors: Bord Vitaly M. , Nathe Lucas M.
Published: February 2022

One of the surprising characteristics of the economic downturn induced by the COVID-19 pandemic is that delinquency rates in most consumer credit markets have remained low both during the downturn and the subsequent recovery. The existing literature has emphasized the roles that forbearance policies and various government stimulus programs played in helping households meet their debt obligations (Dettling and Lambie-Hanson, 2021; Bakshi and Rose, 2021).
Aulas híbridas: la nueva normalidad de la educación superior a partir del Covid-19
Authors: Saavedra Jaramillo de Sedamano Milagritos Josefina , Saavedra Jaramillo Cecilia Caridad , Medina Sotelo Cristian , Sedamano Ballesteros Manuel Alberto , Saavedra Jaramillo Delma Inés
Published: February 2022

El objeto del artículo fue realizar un análisis de la incorporación del método de aulas híbridas a los nuevos cambios producidos en la educación superior a partir de la nueva normalidad, producto de la experiencia vivida por la pandemia Covid-19. La metodología adoptada fue la revisión narrativa, para lo cual se recurrió a diversas fuentes bibliográficas de la temática, utilizando buscadores y bases de datos como Scopus, Web of Science, Scielo y Redalyc. Se concluye que las instituciones de educación superior deben orientar sus capacidades y desempeños a las nuevas oportunidades de aprendizaje a través de las aulas híbridas, mejorando el perfil docente acorde a las exigencias de este modelo, fundamentalmente respecto al manejo de las tecnologías de información y comunicación, que permita canalizar una actitud motivadora y comprometida con el cambio.
Заблудившийся
Authors: Тригг Дилан
Published: February 2022

Исследование Дилана Тригга посвящено конститутивной роли тревоги в становлении субъективности. Хотя тревога занимает центральное место в истории философии — и феноменологии в частности, — пока не было ни одного масштабного исследования того, как она формирует наше ощущение себя и бытия в мире. Опираясь на собственный опыт агорафобии, автор задает ряд критических вопросов: как телесное восприятие других людей влияет на восприятие мира? Какую роль играет настроение в формировании восприятия мира? Как можно понять роль таких состояний, как агорафобия, в контексте нормативных представлений о теле и окружающей среде? Какова связь между тревогой и домом? Автор анализирует странный опыт, когда он не может перейти мост, сесть в автобус или войти в супермаркет без ощущения тревоги. В то же время Тригг обсуждает такие аспекты собственного телесного опыта, которые присущи как агорафобам, так и неагорафобам. Соединяя феноменологическое исследование с актуальными вопросами философии сознания, Тригг приходит к новому представлению об идентичности, которая организует себя, другого и мир как единое целое.
HyDrop Bead Generation & PCR Barcoding v1.0 v9
Authors: De Rop Florian , Poovathingal Suresh , Aerts Stein
Published: February 2022

Protocol for producing dissolvable barcoded hydrogel beads used in HyDrop experiments.
In vitro assembling of RNP for nucleofection of hPSCs v1
Authors: Li Hanqin
Published: February 2022

This protocol describes the procedure for the in vitro assembly of ribonucleoprotein (RNP) which can be delivered into human pluripotent stem cells (hPSCs) using nucleofection. General notes 1. Throughout this protocol, the term hPSC is used to collectively refer to both hiPSCs and hESCs. All described procedures have been tested and work equally well for hiPSCs and hESCs.
Development of a simple and versatile in vitro method for production, stimulation, and analysis of bioengineered muscle v1
Authors: Wells-Cembrano Karen
Published: February 2022

In recent years, 3D in vitro modeling of human skeletal muscle has emerged as a subject of increasing interest, due to its applicability in basic studies or screening platforms. These models strive to recapitulate key features of muscle architecture and function, such as cell alignment, maturation, and contractility in response to stimuli. To this end, it is required to culture cells in biomimetic hydrogels suspended between two anchors. Currently available protocols are often complex to produce, have a high rate of breakage, or are not adapted to imaging and stimulation. Therefore, we sought to develop a simplified and reliable protocol, which still enabled versatility in the study of muscle function. In our method, we have used human immortalized myoblasts cultured in a hydrogel composed of MatrigelTM and fibrinogen, to create muscle strips suspended between two VELCROTM anchors. The resulting muscle constructs show a differentiated phenotype and contractile activity in response to electrical, chemical and optical stimulation. This activity is analyzed by two alternative methods, namely contraction analysis and calcium analysis with Fluo-4 AM. In all, our protocol provides an optimized version of previously published methods, enabling individual imaging of muscle bundles and straightforward analysis of muscle response with standard image analysis software. Although limited by the lack of co-culture with motor neurons, this system provides a start-to-finish guide on how to produce, validate, stimulate, and analyze bioengineered muscle. This ensures that the system can be quickly established by researchers with varying degrees of expertise, while maintaining reliability and similarity to native muscle.
Protocol of a systematic review with meta-analysis: The effects of physical exercise/activity on body composition of individuals with cardiometabolic multimorbidity v1
Authors: Gonçalves Costa Juliene , Mariano Igor , Hugo Carrijo Victor , Zuchinalli Priccila , Morais Puga Guilherme , Aver Bretanha Ribeiro Paula
Published: February 2022

Multimorbidity can be defined as the combination of 2 or more chronic diseases and affects an increasing number of individuals worldwide. Among the various chronic conditions, cardiometabolic diseases stand out as the main causes of death in the world and their management has been increasingly discussed, from the need for specialized clinics, to the creation of a new medical specialty, to the need for effective interventions. The regular practice of physical activity is an important tool recommended to treat and prevent the worsening of the health status of patients with cardiometabolic diseases. In addition, comprehensive monitoring of cardiometabolic parameters such as body composition is necessary to understand the individual's health status, as well as verify the effectiveness of drug treatments and interventions. It is known that exercise has a beneficial effect on these components, but there is still little evidence exploring its effect on the coexistence of diseases and treatments for populations with cardiometabolic multimorbidity. Thus, the objective of the systematic review is to explore the effects of physical exercise and physical activity on body composition in individuals with cardiometabolic multimorbidity. For this, we will carry out a systematic review with meta-analysis in digital databases (PUBMED, EMBASE, CINAHL, Sportsdiscuss and Prospero).
HyDrop-ATAC v1.0 v3
Authors: De Rop Florian , Poovathingal Suresh , Aerts Stein
Published: February 2022

Step-by-step protocol for execution of HyDrop-ATAC.
Catalase test for bacterial identification v2
Authors: not provided lydiariver
Published: February 2022

The catalase enzyme is found in most aerobic and facultative anaerobic bacteria that contain cytochrome, being the main exception Streptococcus. Organisms that do not have the cytochrome system also lack the enzyme catalase and therefore cannot break down hydrogen peroxide.
Strep B Carrot Broth™ chromogenic medium v1
Authors: not provided lydiariver
Published: February 2022

The production of light orange to orange to red-orange pigment is a unique characteristic of hemolytic GBS due to reaction with substrates such as starch, peptone, serum, and folate pathway inhibitors. The advantage to this medium is that it will produce positive results in as little as sixteen hours and does not require subculture to a blood agar plate unless the results are negative. Enrichment broth procedures are known to be more sensitive than plate methods in their ability to detect GBS colonization. Beta-hemolytic, pigment producing GBS occurs with 95 to 99 % of all GBS strains isolated from clinical specimens.
Serotyping v2
Authors: not provided lydiariver
Published: February 2022

Serotyping of Streptococcus agalactiae isolates was carried out by ImmuLex® Strep-B Latex (Statens Serum Institut, Copenhagen, Denmark), classifying them in serotypes 1a,1b, II, III, IV, V, VII, VIII, or IX.
High polarity extracts obtained from Ilex guayusa Loes. leaves, exhibit antioxidant capacity
Authors: RODRIGUEZ AGUIRRE OSCAR EDUARDO , Castañeda Villate Jenny Carolina , Hernández Roa Mayerly Johanna , Cárdenas Tavera Camila Florenza , Pombo Ospina Luis Miguel , Borrego Muñoz Paola
Published: February 2022

Background: Ilex guayusa Loes. belongs to the family Aquifoliaceae. It is an evergreen tree native to the Amazon region. According to traditional uses, it is used as a diaphoretic, narcotic, purgative, among other uses.
 
Objective: To evaluate the antioxidant capacity, quantify phenols and total flavonoids of extracts obtained from Ilex guayusa leaves.
 
Methods: Total ethanolic extract was obtained using Soxhlet-type equipment, with subsequent liquid/liquid fractionation with solvents of different polarities (petroleum ether, dichloromethane, and ethyl acetate); were reacted with 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS•+), determining the inhibitory concentration 50 (IC50) and relative antioxidant activity (%AAR), with subsequent statistical analysis (ANOVA and Tukey's post-hoc). Total phenols and flavonoids were quantified using the Folin-Ciocalteu method and complex formation with AlCl3, respectively.
 
Results: The ethanolic extract of leaves showed the highest antioxidant activity in both the DPPH• and ABTS•+ methods with IC50 values of 4.58 and 3.82 ppm, respectively.
 
Conclusions: According to the results obtained in this study, it was possible to corroborate that the ethanolic extract (EE) obtained from the leaves of I. guayusa showed the highest antioxidant capacity, by the DPPH• and ABTS•+ methods. Additionally, it was possible to relate this capacity to the high flavonoids content present in this extract. Based on the above and accompanied by future studies, the Ilex guayusa species could be proposed as an important source of antioxidant compounds with possible application in medicine and the food industry.
Modified Method of Selection on a Topographic Plan for Reconstructing a Three-Dimensional Scene of Urban Space
Authors:   Institute of Applied Mathematics, Far Eastern Branch of RAS, Vladivostok, Russian Federation, Kudrjashov A. P. , Soloviov I. V. ,   Institute of Applied Mathematics, Far Eastern Branch of RAS, Vladivostok, Russian Federation
Published: February 2022

The article presents a method for identifying contours in a topographic plan, which is a highly noisy binary image of a city development plan. The method of reconstruction is based on use of wave algorithm of Lee. The modified algorithm is compared with the classic wave algorithm. Its modification is proposed, which is aimed at reducing the execution time of the algorithm. Highlighted contours in use for building urban models of objects in scenes of space. Closed contours are recognized on the image, which are then classified into various objects: building outlines, inscriptions, service symbols, etc. Topographic plans are the main initial data at all stages of architectural planning and engineering design. They contain information about the geometry of the foundations of buildings and their position among other objects. Result of work of algorithm — the textured 3D-scene consisting of models of buildings.
Inclusion as a Value in Participation: Children’s Councils in Spain
Authors: Morentín‐Encina Javier , Noguera Pigem Elena , Barba Núñez María
Published: February 2022

The two‐way relationship between inclusion and participation makes municipal child participation organisations and experiences a key means of guaranteeing the inclusion in community life of children and adolescents, who are traditionally excluded from decision‐making and the promotion of changes in the realities of their lives. One of the main objectives of municipal child participation organisations is to ensure that these spaces are inclusive. This means that they must promote equality of guarantees and conditions in the development of the right to participation from a perspective that addresses the different axes of inequality, not only in access to these spaces but also in the relational dynamics that take place in them. Based on a theoretical reflection on inclusion and participation, this article analyses the data from a questionnaire applied to 279 people (191 technical figures and 88 elected authorities) from 179 municipalities in Spain, which seeks to describe the state of child and adolescent participation in municipalities that are part of the International Association of Educating Cities, Child Friendly Cities, or both. A qualitative analysis is made of those issues related to the strategies used to promote inclusion within the Children’s Councils, as well as in the initiatives promoted in the field of child participation. The results show agreement in considering Children’s Councils to be inclusive bodies, but the means and procedures used do not always guarantee this inclusiveness.
Bladder cancer: what's new in 2020-2021
Authors: Karyakin O. B.
Published: February 2022

This article aims to give an up-to-date review of studies on the diagnosis and treatment of patients with bladder cancer (BCa). We emphasize that the assessment of treatment and prognosis using specific markers is a promising method. However, clinical data currently outpace the results of molecular testing. Patients with luminal BCa demonstrate worse response to pharmacotherapy than those with other BCa types. The implementation of new drugs such as avelumab, enfortumab, and new drug combinations into clinical practice raised hopes to improve treatment outcomes of patients with locally advanced and metastatic bladder cancer. The development of new pharmacotherapy and immunotherapy regimens will improve treatment outcomes. We describe the experience of some foreign countries with the treatment and outpatient follow-up of patients after radical cystectomy. The article also contains the guidelines by the European Association of Urology on the treatment of patients with urinary tract cancers during the COVID-19 pandemic.
Roger Guillemin, Andrew Victor Schally, Rosalyn Sussman Yalow
Authors: Karyakin O. B.
Published: February 2022

Research into the physiology of active substances in the 50s of the last century led to the discovery of new peptides, which were named releasing factors, or releasing hormones. The nature of these substances was studied by Roger Guillemin and Andrew Victor Schally. Within a few years, the luteinizing hormone-releasing hormone was isolated, sequenced and synthesized. This discovery laid the ground for modern research on the hypothalamus. Results of animal studies were quickly translated to humans and found their use in clinical practice. The American researcher Rosalyn Sussman Yalow used radioisotopes to measure the volume of circulating blood and to study the distribution of serum proteins in body tissues, as well as to diagnose diseases of the thyroid. Subsequently, a radioimmunological method was developed, including the use of radioactive agents to track various substances in the blood plasma and other tissues. In 1977, Rosalyn Yalow was awarded half of the Nobel Prize in Physiology and Medicine “for the development of radio-immunological methods for the determination of peptide hormones”. Another part of this award was shared by Roger Guillemin and Andrew Schally for a similar research on brain hormones related to “the production of peptide hormones in the brain”. Doctors around the world use the discoveries of these outstanding scientists to improve the quality of life and increase the life expectancy in millions of patients with prostate cancer.
Similarities and differences in the process of metastasis and differentiation of renal cancer on gene expression
Authors: Apanovich N. V. , Matveev A. V. , Apanovich P. V. , Korotaeva A. A. , Kipkeeva F. M. , Muzaffarova T. A. , Khalmurzaev O. A. , Matveev V. B. , Karpukhin A. V.
Published: February 2022

Background. Metastasing and degree of differentiation refer to the main clinical characteristics of malignant tumors. Both listed features need an in-depth study that can lead to an understanding of the mechanisms for the occurrence of certain state of cancer cells.

Objective. Studying the processes of metastasis and differentiation of the clear cell renal cell carcinoma (ccRCC) on gene expression.

Materials and methods. The levels of expression of ten genes in 65 paired samples were studied (ccRCC tumor tissue and the normal kidney tissue) by the real-time polymerase chain reaction.

Results. It is shown that the expression of CA9, NDUFA4L2, VWF, IGFBP3, BHLHE41, ANGPTL4 and EGLN3 genes is associated both with the degree of differentiation of the ccRCC and with the metastasis of this tumor. C1QA expression is connected only with metastasis, but does not participate in the process of differentiation of tumor cells. An ambiguous situation with FN1 and CSF1R gene expression is not essential for ccRCC metastasis processes, but may have a certain value for differentiation of cells of this tumor. Low-differentiated tumors have about five times an increased metastasis frequency during the year relative to highly differentiated tumors (odds ratio 4.94). A low correlation of gene expression in tumors with a low degree of differentiation is revealed, as opposed to their high co-expression during tumor progression by TNM classifications.

Conclusion. A significant part of genes substantial for the development of ccRCC is associated with both metastasis and the degree of differentiation of the ccRCC, which is due to the similarity of functional changes that stimulate both of these processes. For low-differentiated tumors the number of genes with correlated expression is less than in high-differentiated tumors. This may be due to disorganization of gene expression.
Assessment of the state and relationship of vasopressor and renin-angiotensin systems in patients with localized kidney cancer on the background of arterial hypertension
Authors: Osokin R. A. , Aboyan I. A. , Soldatkina N. V. , Komarova E. F. , Maksimov A. Yu. , Vlasov S. N.
Published: February 2022

Background. Vasopressin, in cooperative interaction with angiotensin II, participates in cardiovascular regulation and it increases in arterial hypertension. In addition, vasopressin is involved in tumorigenesis through angiogenesis by stimulating protein synthesis in endothelial cells, induction of endothelin-1, influencing cell proliferation, and stimulating growth factors through VIA receptors in the kidneys. To assess the content of vasopressin, a measurement of copeptin, its precursor, produced in an equimolar ratio, is used.

Objective: to determine the content of serum copeptin and to reveal correlations with the indices of the renin-angiotensin system in the tumor and blood serum in patients with localized kidney cancer (КС) with arterial hypertension (AH).

Materials and methods. The inclusion criteria for the study were initially diagnosed localized KC T1N0M0 without special treatment, age less than 75 years, essential AH of I—II degree without treatment, controlled by angiotensin-converting enzyme inhibitors (ACEi). All patients were divided into groups: patients with KC (n = 42); KC + AH without treatment (n = 31); KC + AH + ACEi (n = 32). Serum levels of copeptin and angiotensin I, II, 1-7 and angiotensin-converting enzyme, angiotensin-converting enzyme 2 were determined by ELISA. Also, the level of components of the renin-angiotensin system was assessed in tumor tissue samples obtained by robotic-assisted kidney resection.

Results and conclusion. In patients of the KC + AH group, the median of the indicator is statistically significantly higher than in the group of healthy donors (2.4 times at p <0.05). In the group KC + AH + ACEi, a decrease in the content of the studied indicator was found in comparison with the norm by 1.2 times (at p <0.05). It was found that the content of copeptin in the tumor less than 4 cm in comparison with the size of 4-7 cm is significantly lower (KC p = 0.045, KC + AH p = 0.067 and KC + AH + ACEi p = 0.036). Correlation analysis showed direct significant links between high density between the levels of copeptin and angiotensin II in the tumor and blood, and moderate tightness with tumor and serum levels of angiotensin (1-7). Multiple regression analysis revealed that the most significant factors that have a positive effect on the concentration of serum copeptin are the content of angiotensin II in the tumor and blood serum, the tumor concentration of angiotensin (1-7) and angiotensin-converting enzyme 2, as well as the level of systolic blood pressure (p <0.05).
Combinatorial radiation therapy for prostate cancer with seminal vesicle invasion
Authors: Makarova K. S. , Gumenetskaya Yu. V. , Biryukov V. A. , Strikanova I. A. , Kireeva T. A. , Lepilina O. G. , Karyakin O. B. , Ivanov S. A. , Kaprin A. D.
Published: February 2022

Background. It seems advisable to investigate the feasibility of radiation therapy combined with hormone therapy to treat locally advanced prostate cancer. Combination of two ways to deliver ionizing radiation doses enables us to elevate a total tumor dose and to reduce radiation exposure to critical organs. However, the feasibility of combinatorial radiation therapy (CRT) in prostate cancer patients with seminal vesicle invasion remains insufficiently investigated. The number of studies focusing on this problem is still extremely small.

Objective of this study is to evaluate the efficacy and toxicity of radiation therapy combined with hormone therapy for prostate cancer with seminal vesicle invasion.

Materials and methods. From April 2016 to April 2020, 52 patients with prostate cancer (cT3bN0) received CRT at the clinic of the A.F. Tsyb Medical Radiological Research Center. The median patient follow-up was 29.7 months (from 11.9 to 58.4 months). The mean age of patients was 65.7 years. The initial mean level of PSA was 28.7 ng/ml. Fifty (96.2 %) patients were given radiation therapy together with hormone therapy.

Results. The tolerability of CRT appeared satisfactory. Grade I acute radiation-induced reactions of the urinary tract occurred in 13 (25 %) patients; grade II ones - in 2 (3.8 %) patients. Grade I acute radiation-induced reactions of the gastrointestinal tract occurred in 11 (21.5 %) patients; grade II ones - in 1 (1.9 %) patient. Grade I late complications of the urinary tract were noted in 4 (7.7 %) patients; grade II ones - in 2 (3.8 %) patients. Grade I late complications of the gastrointestinal tract were noted in 2 (3.8 %) patients; grade II ones - in 3 (5.8 %) patients.

The three-year cancer-specific survival rate was 97 %; the overall survival rate was 83 %. Eight (15.4 %) patients showed prostate cancer progression. Five (9.6 %) patients experienced cancer recurrence in the form of distant bone metastases. In 1 (1.9 %) patient, disease recurrence was associated with involvement of regional lymphatic collectors and distant inguinal lymph node metastases. Local recurrence was noted in 1 (1.9 %) patient. One (1.9 %) patient developed loco-regional recurrence with distant metastasis to bones. The three-year recurrence-free survival rate was 75.6 %.

Conclusion. Our study demonstrates that CRT is highly effective in prostate cancer (cT3bN0) treatment while having an acceptable level of complications.
ALGEBRAIC SYMMETRY MODELS FOR BALTO-SLAVIC FOLKLORE TEXTS
Authors:   Taras Shevchenko national University of Kyiv, NAZAROV Nazarii
Published: February 2022

The present article suggests a tool for describing and analyzing the folklore texts' symmetry by introducing basicconcepts of abstract algebra: set theory, group theory, function, equation, and symmetry. The mathematical model showsthe internal homogeneity of folklore texts composition that is valid across the genre boundaries. The compositionallymeaningful entities of different language levels that constitute the core of a compositional pattern can be divided intotwo sets connected by a function of symmetrical reflection. Each element of the first set A is projected onto the elementof the second set B. The set A can be called input, the symmetrical set B – output. On the metrics and rhyme level, it isa constant reiteration of the same pattern reflected ad infinitum. On the level of syntactic order, this function connectssentences that constitute parallelistic structures. Thus, the composition and perception of folklore texts resemblea succession of linguistic equations: a singer introduces independent variables that should be given a specific dependentvariable, which can be chosen only from the thesaurus of elements accepted by a specific folklore tradition. The functionthat associates elements of the input set with the output set is the folklore poetics itself, so it can be defined in a seriesof elementary equations that show the connection between the number of compositionally significant elements and otherproperties of the texts, mainly the type of symmetry that is inherent to a particular text. Though all main types of symmetrycan be detected in the folklore texts, they can be reduced to a basic operation of reiterating a small number of elements belonging to one set, connected by an operation of symmetrical reflection constituting a group of symmetry. Compositionpatterns of seemingly different genres (riddles, ritual songs, cumulative fairytale, magical fairytale) have one fundamentalfeature in common that underlies them: when the enumeration of the input set A is over, the level of freedom for the choiceof the output set B is highly restricted, as each of the linguistic equations (L. Zadeh) should be solved: the hero, onceborn, should be either married or killed, the riddle should be answered traditionally, set of images of human life shouldbe confronted with the set of corresponding images of nature (in ritual songs), etc., thus giving the recipient pleasureof constant reiteration and decipherment of already known patterns. In this case, the new meaning of folklore texts canbe revealed. By introducing repetitive patterns of composition, they introduced elementary classification and logic tools.In this case, phenomena like I Quing turned out to be not an exception but rather a logical continuation of binary logicof folklore text composition, so overtly represented in the Balto-Slavic area but valid for a much broader realm of folkloretraditions.
Zakariya al-Qazwini’s Al-Aja’ib al-Makhluqat wa al-Gharaib al-Mawjudat and Athar al-Bilad wa Akhbar al-‘Ibad on the Eastern Caucasus: Source Studies
Authors: Gizbulaev Magomed A.
Published: February 2022

This paper provides new information on Dagestans history in the 6th13th centuries through translation, commentary and comparative analysis of excerpts from the Arabic geographical works Ajaib al-Makhluqat wa al-Gharaib al-Mawjudat (Marvels of Creatures and Strange Things Existing) and Athar al-Bilad wa Akhbar al-Ibad (Monuments of Places and History of Gods Bondsmen) by Zakariya al-Qazwini (d. 1283), which concern the history of the Caucasus peoples. The early Arabic accounts in question are not strictly geographical works supplied with astronomical, descriptive data, but a type of book which provides valuable information on historical geography as well as on religion, culture, ethnology, flora and fauna of the Muslim world. As for the reports on religious, cultural and economic life of the region, Qazwini often refers to al-Garnati and repeats data provided by geographers of the 9th13th centuries about the Caspian Sea, Derbent and the Caucasus in general, with the exception of the original information which is not found by other authors on such Dagestan polities as Tsakhur and Shinaz. Moreover, I used a critical approach to A.R.Shikhsaidovs translation of excerpts from the given works by Zakariya al-Qazwini, which not only contains stylistic and interpretational flaws, but also omits some fragments present in the original Arabic texts.
Sound changes to avoid using taboo characters
Authors: Takata Tokio
Published: February 2022

It has been recognized so far that sound change was not used in order to avoid using a taboo character. Nevertheless, we find examples that suggest that there was indeed a habit of changing sounds to avoid using taboo characters in speech. Such sound changes can be seen not only in the case of state taboo, i.e., avoidance of the given names of emperors, but also in the case of secular taboo, e.g., sound changes of the vocabularies for genitals practiced in the Buddhist society. Interesting enough, these sound changes were not a case of temporary substitution but were used as one of the stable pronunciations of the characters.
Two Remarks on the Toyoq Caves and Abita Qur "Abita Cave"
Authors: Matsui Dai
Published: February 2022

IOM RAS preserves 55 Old Uighur manuscripts related to a group of Buddhist Uighurs who were active around the monastery of abita qur Abita Cave at the Toyoq Cave Temples. This paper investigates the location of the Abita Cave through Uighur wall inscriptions, which have been discovered at the monastery complex in the West Zone of the Toyoq site. Furthermore, this paper inquires into an Old Uighur toponym mentioned as the hometown of the scribe of one of the 55 manuscripts, which would suggest the pilgrimage range surrounding the Toyoq Caves
Chinese Stories of Filial Piety in Tangut Literature
Authors: Hongyin Nie
Published: February 2022

Before the formal Chinese compilation of the Twenty-four filial pieties appeared in the Yuan era, there were lots of stories concerning family moral code spreading around the Central Kingdom and along the Gansu Corridor. Most of them entered Xixia through the channels of literary record or oral narration. Some of them were translated into Tangut more than once and became the most popular materials used in moral education for youth and in birthday congratulation for aged people. Sometimes the Tangut versions are quite different from the corresponding Chinese originals in their storylines or even in topics. Such fact shows that Tanguts tried their best to make Chinese culture integrate into their own and lots of their Tangut versions were recomposed through oral literature than historical records. Tanguts did not have the real concept of Twenty-four filial pieties, but their versions concerning filial piety show the transitory stage shortly before the Yuan era.
The Study on the Qing Manuscript Copies of the “History of the Russian State” Kept in Russia
Authors: Liu Ruomei
Published: February 2022

The manuscripts of History of Russian Country, one case and nine volumes, were published in Beijing in the eighth year of Daoguang (1828). They can be rated as the worlds first Russian history in Chinese. There manuscripts are currently in three long-established libraries of St. Petersburg of Russia and there are no collections at home or abroad except for St. Petersburg. History of Russian Country was the Chinese version of the first three volumes of History of the Russian State (a 12-volume national history published in St. Petersburg between the years of 18161826) by the first Russian national historian N.M. Karamzin. It was compiled and translated by Z.F. Leontjevsky during his stay in Beijing (1820-1830), a student of the tenth Russian Orthodox Mission in Beijing. The Chinese version includes the original author Karamzins dedication to the Russian Emperor Alexander I, the foreword, the first volume, the second volume and the third volume (Chapter 7 untranslated). This article compares Leontjevskys Chinese version with Karamzins original Russian version, revealing its values of literature, of Sino-Russian cultural exchanges, and of Russian historiography in Chinese.
OM RAS Tangut Fund History: Hypotheses Based on Some New Facts
Authors: Bogdanov Kirill M.
Published: February 2022

In this article some new facts and hypotheses concerned the IOM, RAS Tangut collections cataloguing and description in the period of 1910s1930s are presented. This data is based on research of description records in the No. 1 and No. 2 inventory books of the Tangut Fund. The main idea assumes that along with N. Nevsky and A. Dragunov other Asiatic Museum researchers could participate in the initial stage of the Tangut Fund inventory work. This hypothesis is based on the obvious difference in handwritings especially in records of inventory book No. 1. It should be noted that all evidences about this period in the Tangut Fund research history are both precise and exiguous in the same time. It is enough to mention the absence of the necessary dates of recordings and names of persons who made it. Considering the whole history of P. Kozlov collection and great interest to collections research can we assume that more than one or two well-known researchers of AM described it too? Maybe yes. Because, apart from incognito hand in the first inventory book, we find oblique or indirect confirmation to it in personal correspondence of N. Nevsky himself. So, despite the significant and basic contribution of Nevsky to first cataloguing work with Tangut books biggest collection, it is logically to propose that it should be collective work too. If we follow the research history of Kozlov archeological findings after Khara-Khoto and then, we recognize the rightfulness of this assumption.
Substitusi Tepung Ikan Teri (Stolephorus sp.) dalam Pembuatan Kue Semprong sebagai Sumber Kalsium untuk Anak Sekolah
Authors: Adlina  , Ratnaningsih Nani , Lastariwati Badraningsih
Published: February 2022

Salah satu bahan pangan sumber kalsium yang dibutuhkan oleh anak-anak adalah ikan teri, namun pemanfaatannya dalam produk makanan tradisional masih terbatas. Kue semprong mempunyai potensi sebagai makanan tradisional yang bersifat fungsional. Penelitian ini bertujuan untuk mengetahui formulasi kue semprong dengan substitusi tepung ikan teri medan, tingkat kesukaan dan kandungan gizinya dengan uji proksimat dan kalsium. Penelitian dilakukan dalam empat tahap yaitu define untuk menemukan resep acuan kue semprong, design untuk mengembangkan resep acuan terpilih dengan substitusi tepung teri medan sebanyak 5%, 10%, dan 15% development untuk uji validitas kepada ahli pangan dan gizi serta merancang kemasan kue semprong teri medan, serta terakhir disseminate untuk menguji kesukaan produk oleh 100 panelis dari anak sekolah. Substitusi tepung ikan teri medan pada kue semprong yang terbaik yaitu 15%. Uji kesukaan terhadap produk acuan yaitu 4,0 (disukai) dan produk pengembangan yaitu 4,9 (sangat disukai). Kandungan gizi kue semprong teri medan terdiri dari protein 10,77 g, lemak 26,49 g, karbohidrat 57,04 g, dan energi 486,65 kkal/100 g produk. Kue semprong teri medan dapat dikategorikan sebagai camilan sumber kalsium karena mengandung kalsium 820,63 mg/100 g. Oleh karena itu, kue semprong teri medan dapat direkomendasikan sebagai camilan untuk anak sekolah.
Genetic Diversity of Mulberry Cultivars using ISSR and SRAP Molecular Markers
Authors: Zhang Nan
Published: February 2022

Mulberry, a kind of Morus (Moraceae), is an important perennial economic plant, with leaves used to feed silkworm. It is important to reveal the relationship between the genetic variation and evolution of mulberry and to reveal the phylogenetic of its germplasm. In the present study, the genetic diversity of the gene structure characteristics of 23 main mulberry in Sichuan Province (China) based on inter-simple sequence related (ISSR), sequence-related amplified polymorphism (SRAP) markers and sequencing analysis was reported. 12 ISSRs and 5 SRAPs were exploited, chosen to evaluate the polymorphism level and the discriminating capacity from 100 ISSR primers and 50 SRAP primer. The 12 ISSRs generated 116 repeatable amplified bands, of which 93 (80.24%) were polymorphic. The amplified fragment size was between 0.1–1.5 KB. The 5 SRAP primers produced 31 repeatable amplified bands, of which 24 (77.42%) were polymorphic. The amplified fragment size was also between 0.1–1.5 KB. The study indicated that, ISSR and SRAP markers were reliable and effective to assess the genetic relationship and genetic diversity of 23 main mulberry varieties of Sichuan Province (China). The results provided the scientific basis for the establishment and identification of DNA fingerprint of mulberry varieties germplasm resources. © 2019 Friends Science Publishers
Una estrategia docente basada en el flipped classroom para mejorar la enseñanza de contenidos prácticos en asignaturas STEM
Authors: Zaplana Isiah , Rosell Jan
Published: February 2022

En algunas asignaturas STEM, el bloque práctico incluye el uso de programas informáticos desconocidos para los alumnos. Esto origina una serie de problemas para el alumnado tales como la falta de aprovechamiento de las sesiones prácticas, desmotivación y frustración. A fin de incrementar la motivación, satisfacción y aprovechamiento de los alumnos de las sesiones prácticas, este artículo propone una innovación docente basada en el flipad classroom. Las ventajas propias de la estrategia presentada en este artículo son la estimulación del trabajo autónomo y del trabajo en equipo. Además, permite que las sesiones presenciales puedan centrarse en lo verdaderamente relevante de la asignatura mediante un aprendizaje basado en problemas. Después de revisar la literatura, se ha desarrollado la propuesta concreta a implementar y se ha verificado que cumple con los criterios de calidad de Chikering y Gamson. Se han planteado las diversas evidencias que se recogerán para el posterior análisis objetivo del impacto de esta innovación docente en los estudiantes.