bluuebunny/crossref_metadata_2025 huggingface dataset:
In-Hospital Outcome of Patients with Diabetes Mellitus after CTO Recanalization with Third-Generation Drug-Eluting Stents
Authors: Guelker Jan-Erik , Bansemir Lars , Ott Rainer , Rock Thomas , Guelker Rosemarie , . MSc , Shin Dong-In , Klues Heinrich , Bufe Alexander
Published: August 2019

Background: Percutaneous coronary intervention (PCI) of total chronic coronary occlusions (CTOs) still remains a major challenge in interventional cardiology. There is little knowledge in the literature about differences in CTO-PCI between diabetic and nondiabetic patients in the era of third-generation drug-eluting stents (DESs). In this study, we analyzed the impact of diabetes mellitus (DM) on procedural characteristics, complications, and acute outcomes in a cohort of 440 patients.
Methods: Between 2012 and 2016, we recruited 440 consecutive patients, 116 of them with DM. All the patients underwent PCI for at least 1 CTO. Antegrade and retrograde CTO recanalization techniques were applied. Only third-generation DESs were used. We used t-tests and the Pearson chi-quadrat test to test the significant differences in the variables between the 2 groups.
Results: The patients with DM were older than the nondiabetics (64.5 y vs. 61.1 y; P=0.003), and they suffered more frequently from a chronic kidney disease (7.1% vs. 2.4%; P=0.001). The nondiabetics less frequently had arterial hypertension (75.3% vs. 89.7%; P=0.001); however, they more often had a family liability for CAD (32.1% vs. 22.4%; P=0.050) and had a higher left ventricular  ejection fraction (59.2% vs. 56.7%; P=0.011). The success rate was 85.2% in the patients without DM and 81.2% in the patients with DM (P=0.403). The existence of DM had no impact on the procedural success and complication rates.
Conclusion: Our study on 440 patients shows that diabetics and nondiabetics have similar success and complication rates after the recanalization of CTOs using third-generation DESs. It is a feasible and safe procedure and can be recommended as an alternative treatment.
 
J Teh Univ Heart Ctr 2019;14(2):47-52
 
This paper should be cited as: Guelker J. E, Bansemir L, Ott R, Rock T, Guelker R, Shin D. I, Klues H. G, Bufe A. In-hospital Outcome of Patients with Diabetes Mellitus after CTO Recanalization with Third-Generation Drug-Eluting Stents. J Teh Univ Heart Ctr 2019;14(2):47-52.
Comparison of Short-Term Results between Patients Undergoing Coronary Artery Bypass Graft with a Stent-Placement History and Patients Undergoing Primary Coronary Artery Surgery
Authors: Hadadzadeh Mehdi , Mirahmadi Mahdiesadat , Mirzaei Masoud , Pedarzadeh Ali , Ghasemzadeh Bahram , Rahimianfar Ali Akbar
Published: August 2019

Background: Percutaneous coronary intervention (PCI) has become the first-choice treatment strategy the world over for patients with chronic coronary artery disorders. This study compared the effects of previous PCI procedures on the short-term postoperative results of coronary artery bypass graft surgery (CABG).
Methodsː This cross-sectional analytical study recruited 220 patients who underwent CABG in Afshar Hospital in the Iranian city of Yazd between March 2009 and February 2013. The mean postoperative morbidity and mortality rates, the mean postoperative left ventricular ejection fraction (LVEF), the mean hemorrhage volume, the mean serum urea level, and the mean length of stay in the intensive care unit (ICU) were compared between the PCI and non-PCI groups.
Results: Among the 220 participants, 147(66.8%) were male and 73(33.2%) were female. The mean age of the study population was 59.41±10.52 years. There was no significant difference in the risk of mortality between the 2 groups (P=0.369). The mean serum urea level was 21.14±6.52 mg/dL in the PCI group and 14.45±1.08 mg/dL in the non-PCI group (P=0.016). The mean postoperative LVEF was 43.19±8.81% in the PCI group and 45.51±8.15% in the non-PCI group (P=0.044). The mean length of stay in the ICU was 3.34±1.23 days in the PCI group and 2.22±0.56 days in the non-PCI group (P<0.001). The mean hemorrhage volume was 1113.01±428.13 mL in the PCI group and 961.42±228.31 mL in the non-PCI group (P=0.027).
Conclusion: Previous PCI procedures did not affect the post-CABG mortality rate; however, some postoperative results were worse in the PCI group than in the non-PCI group, which should be considered before the selection of the revascularization method.
 
J Teh Univ Heart Ctr 2019;14(2):53-57
 
This paper should be cited as: Hadadzadeh M, Mirahmadi M, Mirzaei M, Pedarzadeh A, Ghasemzadeh B, Rahimianfar AA. Comparison of Short-term Results between Patients Undergoing Coronary Artery Bypass Graft with a Stent-Placement History and Patients Undergoing Primary Coronary Artery Surgery. J Teh Univ Heart Ctr 2019;14(2):53-57.
Transcatheter Self-expandable Aortic Valve (Portico) Implantation in a Patient with Previous Mitral Valve Replacement: A Case Report
Authors: Korkmaz Ahmet , Gürsoy Havva Tuğba , İleri Mehmet , Elalmış Özgül Uçar , Güray Ümit
Published: August 2019

Transcatheter aortic valve implantation (TAVI) has shown favorable outcomes in patients with severe symptomatic aortic valve stenosis who are at high surgical risk or who are unsuitable candidates for open-heart surgery. However, concerns exist over treating patients who have undergone previous mitral valve surgery due to the potential interference between the mitral prosthetic valve or ring and the TAVI device. In this case report, we present a case in which a patient with symptomatic severe aortic stenosis and previous mechanical mitral valve replacement was successfully treated with TAVI using a Portico valve, which is under-researched.
 
J Teh Univ Heart Ctr 2019;14(2):85-89
 
This paper should be cited as: Korkmaz A, Gürsoy HT, İleri M, Uçar Elalmış Ö, Güray Ü. Transcatheter Self-expandable Aortic Valve (Portico) Implantation in a Patient with Previous Mitral Valve Replacement: A Case Report. J Teh Univ Heart Ctr 2019;14(2):85-89.
Huge Hiatal Hernia Mimicking a Mass with Compressive Effects on the Left Atrium Causing Paroxysmal Atrial Fibrillation
Authors: Akçay Murat , Çamlıdağ İlkay
Published: August 2019

An 82-year-old female patient presented with complaints of dyspnea and increasing palpitations caused by food reflux. There was no risk factor except hypertension. On physical examination, the heart rate was 120 beats/min and arrhythmic and blood pressure was 130/80 mmHg. Electrocardiography showed high-rate atrial fibrillation. Laboratory parameters were unremarkable. Echocardiography illustrated a hyperechogenic and well-circumscribed mass, 40×55 mm size, in the posterior left atrium (Figure 1, Video 1). The mass size increased with breathing and the Valsalva maneuver. There was no pathology on chest radiography. The atrial fibrillation returned to sinus rhythm spontaneously, but paroxysmal atrial fibrillation attacks were observed, which were related to food reflux at follow-up. Subsequently, cardiac computed tomography, performed to determine the etiology, failed to demonstrate any pathological findings involving the left atrium. However, there was a sliding hernia in the paraesophageal region compressing the left atrium from the inferior-posterior region (Figure 2). Hiatal hernia surgery was recommended on account of the intermittently repeating symptoms. The patient refused the operation, and she is under follow-up with medical treatment.
Aortic Pseudoaneurysm in an Unusual Site: Difficult Diagnosis by Echocardiography
Authors: Hosseinsabet Ali , Aghagani Hasan , Forozannia Khalil , Yaminisaharif Ahmad
Published: August 2019

A 54-year-old woman was admitted to our hospital with a fever of 1 week’s duration and a distal embolic event 4 days previously in the second and third digits of her right hand. She had a history of aortic valve replacement (STj#19) 2 months earlier as well as mitral valve replacement (STj#26) and tricuspid valve repair 10 years before. Lab data showed an increased white blood cell count and an elevated erythrocyte sedimentation rate. Blood culture was positive only in 1 round with Pseudomonas aeruginosa growth, which was not compatible with the patient’s good general condition. Transthoracic and transesophageal echocardiography, abdominal sonography, and computed tomography (CT) scan of the right hand were unremarkable. The patient was treated for infectious endocarditis with antibiotics for 6 weeks and then discharged. On follow-up transthoracic echocardiography, 1 month after discharge, an echo-free space in the posterolateral wall of the ascending aorta was detected. The second transesophageal echocardiography was highly suggestive of a pseudoaneurysm in the ascending aorta (Figure 1A & Video 1), which was subsequently confirmed by a CT angiography of the ascending aorta (Figure 2). For a better evaluation, aortography was done and it revealed a pseudoaneurysm in the posterolateral wall of the ascending aorta (Figure 3 & Video 2). A review of the previous transthoracic and transesophageal echocardiography images demonstrated that this pseudoaneurysm had been missed because it was filled with a thrombosis (Figure 1B & Video 3). The ascending aorta was normal in aortography before the second surgical operation. It appears that the most probable scenario was thrombosis formation in an iatrogenic aortic pseudoaneurysm at an unusual site, causing such presentations. The thrombosis was resolved with meticulous anticoagulation, leading to the clarification of the pseudoaneurysm. The administration of an anticoagulant was obligatory in this patient because of the presence of 2 mechanical valves. Nevertheless, this administration could lead to catastrophic events such as a ruptured ascending aorta, so the early detection of this complication may reduce the risk to the patient and confer an appropriate treatment. We repaired our patient’s pseudoaneurysm via surgery, and she was discharged in good physical condition. The development of an aortic pseudoaneurysm is an uncommon complication of open-heart surgery, and it usually forms in the anterior wall; nonetheless, its formation in the posterior wall is rare and can be due to the deep cannulation of the ascending aorta during surgery. The presence of this complication should, therefore, be kept in mind by any cardiologist who encounters a patient with an embolic event and previous cardiac surgery.
Sparking a Movement for a Healthy Climate through Leadership Development
Authors: Kerr Rachel , Nerbonne Julia Frost , Potter Teddie
Published: August 2019

Climate change is increasingly impacting health, and health care is contributing to climate change through carbon emissions. Nurses can help mitigate climate change and its effects through leadership development initiatives to expand the impact of the efforts of a single person by activating others. This article describes one such nurse-led leadership development project. The intervention adapted a workshop series curriculum for faith community audiences to a health professional audience. The program gave participants the ability to assess their assets, understand the psychology of communication of climate change, and design appropriately-scaled actions to help mitigate climate change. The program consisted of three in-person workshop sessions plus bi-weekly individual consultations with participants. The seven participants included physicians, nurses, physician and nurse educators, a public health professional, and a veterinary medicine student. The workshops included content on communicating about climate change, crafting a public narrative/storytelling, and tools and methods for organizing in the climate movement. Participants completed action plans including a broad range of leadership efforts as part of the intervention; all participants completed at least the first step of their action plan during the program period. Qualitative interviews highlighted facets of participants ‘experiences. Nurses and other health professionals are leading the way in mitigating climate change; leadership development programs such as this are one way of taking effective climate action.
Beyond the Slogans: Understanding the Ecological Consciousness of Nurses to Advance Ecological Knowledge and Practice
Authors: Hanley Fiona , Jakubec Sonya L.
Published: August 2019

Despite unprecedented global environmental changes with widespread health effects, and rapid advances in nursing knowledge and education, the concept of environment within the discipline remains restricted. Environmental health continues to be marginalized in nursing education and practice, with nurses struggling to get beyond the slogans to arrive at practical applications. Framed by ecohealth and radical ecopsychology theory (concerned with nature connection, individual wellness, and social/earth justice), this study employed an online survey ( n = 40) with thematic content analysis. The study explored factors that influenced eco-consciousness, how it affected nursing work, and how it was integrated into practice The 40 participants from 3 Canadian provinces included 32 nurses employed in education and clinical practice and 8 student nurses. Three main themes emerged: awakening consciousness, challenges in the discipline and profession, and finding opportunities. In particular, the students expressed a need for early integration of environmental health teaching into curriculum. Results illustrate an ongoing knowledge-practice gap and highlight the frustration and dismay of nurses whose efforts remain marginalized. Motivations and opportunities for nurses to undertake an expanded role in adopting environmental health as central to the discipline and practice of nursing can and must be more intently harnessed. As curricular approaches are expanded, further inquiry is proposed into the role of both early experiences and nursing education to transform the response to the ecological crises of our times.
HOW MUCH HEAVIER IS A “HOE” FOR WOMEN? WAGE GENDER DISCRIMINATION IN THE BRAZILIAN AGRICULTURAL SECTOR
Authors: Schwaab Kalu Soraia , Dutra Vanessa Rabelo , Marschner Paulo Fernando , Ceretta Paulo Sergio
Published: August 2019

This paper aims at analyzing the existence of wage differentials by genders in the agricultural labor market in the Brazilian rural area, with the purpose of verifying if the differentials are due to differences in explained characteristics or discriminatory. Equations were estimated and the wage differential detailed decomposition with microdata from the PNAD 2015 with the Heckman's correction. The method used was the decomposition of Oaxaca-Blinder. The main results show that the wage/hour of men is 157.62% higher than that of women, and the effect of discrimination is 108.38% this gap. The main conclusion indicates that the gender wage differential decreases with the formality of work and with the increase of hours worked by women. It is worth nothing that the results provide the visualization of gender discrimination in the rural labor market, adding contributions to the empirical studies on wage differentials.
ANÁLISE DA PERSISTÊNCIA DO LUCRO DIANTE DOS ACCRUALS DISCRICIONÁRIOS: UM ESTUDO COM BASE NO IMPACTO DA ADOÇÃO DAS IFRS
Authors: Marçal Ronan Reis , Macedo Marcelo Alvaro da Silva
Published: August 2019

A diferença entre o fluxo de caixa e o resultado do exercício chama-se accrual. Esta medida divide-se em uma parcela discricionária, proxy de gerenciamento de resultados, e outra não discricionária, natural das atividades operacionais. A implementação das normas internacionais de contabilidade (IFRS) gerou potencial de mudanças no volume da parcela discricionária. Dela espera-se um prejuízo na persistência dos lucros dado seu caráter arbitrário. Portanto, este estudo analisou o impacto dos accruals discricionários na persistência dos lucros das empresas da B3, considerando a adoção das IFRS. Diante de uma estimação com dados em painel de 100 diferentes empresas, há indícios contrários à lógica de deterioração da persistência pelos accruals discricionários. A explicação reside no gerenciamento de resultados não oportunísticos, que auxilia investidores na tomada de decisão. Ademais, a adoção das IFRS não implica reflexos na relação das acumulações discricionárias com a persistência dos lucros, diferentemente do esperado conforme estudos anteriores.
SEGURANÇA CIDADÃ: FORMAS DE ENVOLVIMENTO E PROPENSÃO DO CIDADÃO À COPRODUÇÃO DE SEGURANÇA PÚBLICA NO DISTRITO FEDERAL
Authors: Martins Isabela Miranda , Farias Josivania Silva , Angelo Junior Lucio Alves
Published: August 2019

Este estudo identificou formas de envolvimento do cidadão na segurança pública, considerando as atividades desempenhadas pelos cidadãos e a propensão para a coprodução de segurança no Distrito Federal. Em estudo qualitativo-descritivo, foram realizadas 82 entrevistas semiestruturadas com cidadãos residentes no Distrito Federal, sendo 22 engajados em mecanismos formais de coprodução e 60 não engajados nesses mecanismos. Os dados foram analisados por meio de análise de conteúdo, utilizando a técnica de saturação teórica. Observou-se que os sujeitos do estudo contribuem com a segurança pública por meio de ações de natureza preventiva e repressiva, sendo identificadas as formas de coprodução de informação, política, social, econômica, preventiva e repressiva. Quanto à propensão a coproduzir, constataram-se sete aspectos que tornariam os cidadãos mais propensos a coproduzir, ampliando a compreensão acerca do fenômeno da coprodução da segurança pública.
CADEIA VERDE DE SUPRIMENTOS: ASSOCIAÇÕES ENTRE DIRECIONADORES, PRÁTICAS E DESEMPENHO
Authors: Goularte Gustavo Neves , Dias Marcelo Fernandes Pacheco
Published: August 2019

Esta pesquisa analisou quais são e como se associam entre si os direcionadores externos e internos, as práticas verdes e o desempenho econômico e ambiental numa cadeia verde de suprimentos (Green Supply Chain Management – GSCM). O estudo se motivou pelo número limitado de estudos sobre como os elementos de uma GSCM se associam entre si e principalmente no setor portuário. Para atender a este objetivo, foi realizado um estudo de caso na cadeia verde de suprimentos do Terminal de Contêineres do Porto de Rio Grande. Como resultado, foi possível identificar um sistema complexo de partes (direcionadores externos, internos, práticas e indicadores de desempenho) e associações que envolve a GSCM estudada. Evidenciaram-se associações específicas entre direcionadores e práticas desenvolvidas, bem como entre práticas de GSCM e os indicadores de desempenho. Há práticas que contribuem para ambos os desempenhos. Os direcionadores externos podem condicionar diretamente a presença de indicadores de desempenho.
Investigation of Pre-service Primary School Teachers' Decision Processes Related to Genetic-based Socioscientific Discussions in Terms of Human Rights
Authors: ÖZTÜRK Ayşe , DOĞANAY Ahmet
Published: August 2019

In this study, it was aimed to investigate the decision processes of pre-service primary school teachers (PPSTs) related to genetic-based socioscientific discussions in terms of human rights. In this context, in the study, it was focused on the birth of gifted people with genetic technology, the use of genetic tests in the process of getting health insurance, and gender selection by the PGD method. The study was carried out as a descriptive study in the screening model with 203 PPSTs studying at the fourth grade in three faculties of education in the Southeastern Anatolia region in Turkey. In the study, the data were collected with the Evaluation Form for Decision Processes related to Genetic-based Socioscientific Discussions. Research data were analyzed by content analysis. The results of the study indicated that PPSTs used different decision processes in genetic-based socioscientific discussions and based these decision processes on different justifications. Furthermore, they also revealed that PPSTs largely made decisions that were unrelated to human rights in genetic-based socioscientific discussions. However, they could usually make accurate inferences when they made human rights-based decisions. This study is important in terms of providing information on how PPSTs' decision processes related to genetic-based socioscientific discussions are shaped and on how human rights are employed in this process.
Perlindungan Hukum Terhadap Anak Korban Eksploitasi Seksual Komersial Melalui Media Sosial
Authors: Rizky Mutiara Nastya , Fitriani Risma Intan , Sudibyo Muhammad Wahyu , Husnasari Fatma Ayu , Maulana Firmansyah
Published: August 2019

Today, the crime rate is increasing, one of the trigger is due to the advances in the field of technology and information. Thus not a few people who use technological advances as a crime media to make money. Most of them use children as objects because children are easily persuaded and seduced to get something. One example of a crime that uses a child as an object is a sexual crime. These children are exploited as sexual disseminators disseminated through social media. Looking at the children's point of view as a weak individual then in Indonesia Law number 35 of 2014 was born to ensure that children can grow and develop optimally. So the law is regulated in detail about the rights of children and protection of children as victims of crime. On the other hand, there are several laws that regulate sexual crimes whether committed in cyberspace or not. Because of the importance of providing protection to children, there is more than one rule of law to protect children as victims of sexual crimes through social media. So the systematic specialist principle should be applied to provide legal certainty against the children. The purpose of this research was to determine the legal protection of children as victims of sexual exploitation through social media and the application of lex specialist systematic principles in the case of children as victims of sexual abuse through social media. To be able to answer existing legal problems, the research method is used with the type of doctrinal research and statute approach and conceptual approach. From this research, it can be obtained the results that in the application of the lex systematic specialist principle is based on case.
Prospek Penerapan Online Dispute Resolution dalam Upaya Penyelesaian Sengketa Bisnis di Indonesia
Authors: Azwar Muhammad
Published: August 2019

Penyelesaian sengketa secara online belum diatur secara eksplisit di Indonesia sehingga perkembangan yang pesat dari informasi, teknologi, dan bisnis tidak dapat seimbang dengan aturan hukum positif. Peneliti dalam hal ini membahas prospek penerapan online dispute resolution sebagai model penyelesaian sengketa bisnis di Indonesia. Metode pendekatan yang digunakan adalah pendekatan perundang-undangan, pendekatan konseptual, dan pendekatan futuristik. Dari hasil penelitian ini didapatkan bahwa penyelesaian sengketa secara online merupakan salah satu wujud pembaharuan secara modern dari penyelesaian sengketa alternatif yang merupakan penyelesaian yang dikembangkan dengan teknologi dan internet melalui dunia maya dengan memudahkan dan menguntungkan para pelaku bisnis dalam upaya penyelesaian sengketa yang timbul sehingga hukum positif dapat mengimbangi laju perdagangan global, teknologi, dan informasi yang begitu cepat.
Automatic Exchange of Information on Indonesia Jurisdiction in order to Control Business Opportunities
Authors: Tedja Adrian Adhitana , Wijaya Vincent Arta , Lidyawati Jevelyn
Published: August 2019

The Automatic Exchange of Information (AEOI) is a product of  common reporting standard as a result of Indonesia's ratification of the Convention on Mutual Administrative Assistance in Tax Matters. The convention purpose is to  prevent transnational tax evasion and money laudry, with the existence of an automatic exchange of information system through out members of the convention can enact and enforce its laws. The main problems concerning an autamated system is the jurisdiction regarding the enacting state, as well as bank secrecy laws in ratifying countries. With banks are compromised to reveal tax payers information to the state, many tax payers will eventually lose interest in one state and start seeking tax havens, which will impact the economy and business sectors as well as trade policies between states. The purpose of this research is to find out what law governs AEOI in Indonesia and its impact on transnational jurisdiction between ratifying and non-ratifying states. This research is a juridical-emphirical research which uses statute approach, conceptual approach and comparative approach. The research compares Indonesia laws including banking law as well as statistics of Indonesian economic growth since the enactment of tax amnesty as a reaction towards AEOI.
Kedudukan Legitieme Portie dalam Hal Pemberian Hibah Wasiat Berdasarkan Hukum Waris Burgerlijk Wetboek
Authors: Marthianus Willliam Setiawan
Published: August 2019

Will is one of the ways to inheritance. According to article 875 BW, a testament or last will is a deed, containing a statement of an individual’s wishes and intents to take effect following his death, and which deed can be revolved. Testament or last will can be made while the testator is still alive, but the implementation is only do able when the testator passed away. Testamentary offers an additional option to testator while he/she is still alive the inheritance can be distributed to the beneficiary or heir, according to article 957 BW, testamentary gifting is a special testament, under which the testator bestows onto one or more person his properties of a certain kind, for example, all of his properties, movable or immovable, or the usufruct rights over entire part of his estate. It is special testament because it can pass distributed the inheritance on special occasion such as when the amount of successor is more than one, it can give special and certain kind of properties, such as movable or immovable properties, and usufruct rights. Problem arise when testamentary gifting is given to the successor without obeying the provisions according to legitimate portie. This condition is contrary with article 913 BW which states that The Legitimate portion or the legal share of the inheritance is that portion of the estate which the lawful heirs in a direct line are entitled to and which the testator is not entitled to dispose of as a gift during his life time or by last will.
MENINGKATKAN PEMAHAMAN KONSEP SISWA DENGAN MENGGUNAKAN MODEL GUIDED INQUIRY DISCOVERY LEARNING (GIDL) DI KELAS X PMIA-2 SMAN 3 BANJARMASIN
Authors: Audina Mia , Arifuddin M , Misbah Misbah
Published: August 2019

Kurangnya peran aktif siswa selama proses pembelajaran mengakibatkan siswa menjadi bosan dikelas sehingga berpengaruh terhadap hasil belajar khususnya dalam pemahaman konsep. Penelitian ini bertujuan untuk mendeskripsikan (1) keterlaksanaan RPP, (2) aktivitas siswa, (3) pemahaman konsep siswa, (4) hasil belajar siswa. Model penelitian tindakan kelas Kemmis & Mc Taggart yang digunakan dalam metode penelitian. Subjek penelitian adalah 37 orang siswa. Teknik pengumpulan data berupa tes hasil belajar, lembar pengamatan. Hasil penelitian menunjukkan bahwa dengan menerapkan model pembelajaran GIDL (1) keterlaksanaan RPP pada siklus I, II, dan III berkategori sangat baik, (2) aktivitas siswa mengalami peningkatan pada setiap aspek dengan berkategori cukup, baik dan sangat baik, (3) ketuntasan pemahaman konsep siswa meningkat, secara berturut-turut ketuntasan individual pada sikus I, II, dan III sebesar 29,73%, 64,90%, dan 94,60%, (4) hasil belajar siswa meningkat, secara berturut-turut ketuntasan individual pada siklus I, II, dan III sebesar 81,08%, 89,19%, dan 100%. Diperoleh simpulan bahwa untuk meningkatkan pemahaman konsep siswa dapatdilakukan dengan menerapkan model pembelajaran GIDL.
Clinical Importance of Drug Adherence during Tyrosine Kinase Inhibitor Therapy for Chronic Myelogenous Leukemia in Chronic Phase
Authors: Maeda Yasuhiro , Okamoto Atsushi , Yamamoto Kenta , Eguchi Go , Kanai Yoshitaka
Published: August 2019

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm constituting approximately 15% of newly diagnosed leukemia in adult patients. Development of tyrosine kinase inhibitors (TKIs) have dramatically improved outcomes in patients with chronic CML in chronic phase. However, adverse drug events (ADEs) associated with TKI therapy have influenced drug adherence, resulting in adverse clinical outcomes and a decline in the quality of life (QoL). In this study, we carried out a unique questionnaire survey to evaluate ADEs, which comprised 14 adverse events. We compared drug adherence rates between patients using imatinib and those who switched from imatinib to nilotinib, a second-generation TKI. Following the switch, the total number of ADEs decreased considerably in most cases. Simultaneously, better QoL was observed in the nilotinib group than in the imatinib group. Drug adherence was measured using Morisky’s 9-item Medication Adherence Scale (MMAS). MMAS increased significantly after switching to nilotinib in all cases. Drug adherence is a critical factor for achieving molecular response in patients with CML. In fact, our results showed a strong inverse correlation between clinical outcome [international scale (IS)] and adherence (MMAS), with a stronger tendency in the nilotinib group than in the imatinib group. In conclusion, low occurrence of ADEs induced a high level of QoL and a good clinical response with second-generation TKI nilotinib treatment.
Treatment with DHA Improves Epidermal Eeratinocyte Differentiation and Ameliorates Inflammation in Human Keratinocytes and Reconstructed Human Epidermis Models
Authors: Jia Tinghan , Qiao Wu , Yao Qifeng , Wu Wenhui , Kaku Ken
Published: August 2019

Atopic dermatitis (AD) is a chronic inflammatory skin disease, which can cause skin barrier function damaged. Although co-incubation with docosahexaenoic acid (DHA) exerts a positive effect in deficient skin model, there is no study to investigate the effects of topical treatment with DHA in inflammatory reconstructed human epidermis (RHE) model. The effects of DHA on monolayer normal human epidermal keratinocyte (NHEK) cells were evaluated via CCK-8, qPCR and ELISA. The skin related barrier function was assessed by hematoxylin-eosin (HE) staining, western blot (WB), Immunohistofluorescence (IF) and ELISA in normal and inflammatory RHE models. DHA upregulated filaggrin and loricrin expression at mRNA levels in addition to suppress overexpression of TNF-α，IL-1α and IL-6 stimulated by poly I:C plus LPS (stimulation cocktail) in cultured NHEK cells. After topical treatment with DHA, cocktail induced inflammatory characteristics of skin diseases including barrier morphological, differentiation proteins and TSLP secretion, which were alleviated in RHE models. Supplementation with DHA can improved related barrier function and have anti-inflammation effects in monolayer keratinocytes and RHE models, which indicated that DHA may have a potential value for the treatment of inflammation-associate skin diseases.
Application-Specific Oxide-Based and Metal-Dielectric Thin Film Materials Prepared by RF Magnetron Sputtering
Authors: Nur E Alam Mohammad , Lonsdale Wade , Vasiliev Mikhail , Alameh Kamal
Published: August 2019

We report on the development of several different thin-film functional material systems prepared by RF magnetron sputtering at Edith Cowan University nanofabrication labs. We conduct research on the design, prototyping, and practical fabrication of high-performance magneto-optic (MO) materials, oxide based sensor components, and heat regulation coatings for advanced construction and solar windows.
The Effect of Hypo-Hydration on Mood and Cognition is Influenced by Electrolyte in a Drink and Its Colour: A Randomised Trial
Authors: Cousins Alecia L. , Young Hayley A. , Thomas Andrew G. , Benton David
Published: August 2019

Traditionally it has been thought necessary to lose 2% of body mass due to dehydration, before functioning is disrupted, although recently adverse effects have been reported with a loss of 0.5-0.7%. It is, however, unclear whether the response to small decreases in mass reflects dehydration, mechanisms that help to adapt to a loss of bodily fluid, or a placebo effect. Individuals were therefore subject to a temperature of 30°C for three hours, and mood and cognition monitored. To explore the possibility of a placebo response, the consumption of plain or coloured water was compared. To consider changes in hydration status, drinks known to differ in their ability to rehydrate were contrasted. Not drinking was disruptive, although a combination of plain water and electrolyte’s most effectively prevented a decline in functioning, indicating a role for rehydration after a loss of 0.52% body mass. There was, however, also evidence of a placebo response: a combination of plain water and electrolytes was better able to prevent a decline in functioning than coloured plain water and electrolytes. As increased anxiety was a robust response, it was discussed whether the renin–angiotensin–aldosterone system might be part of the mechanism.
Basic Mechanism of Sweating and Its Role in Temperature and Appetite Regulation: An Ayurvedic Perspective
Authors: Dubey Sushil Kumar , Aftab Anam , Tripathi Suyash , Dubey Ramesh Kant , Srivastava Shivani , Tripathi Yamini Bhusan
Published: August 2019

Background: Sweat excretion from eccrine sweat glands, is primarily considered for theromoregulation. It loses body heat by means of it is more active during exercise or hot environmental conditions. In Ayurveda, sweat (Sveda) is defined as the waste product of fat tissue (Meda Dhatu). Besides it is also linked to Pitta Dosha, responsible for all metabolic process in the body. Aim and Objective: Thus it is proposed that sweating regulates temperature but also reduces the metabolism. This may lead to loss of appetite, lesser energy and also compromised digestive potential (Jatharagani). Materials and Methods: This review initially focuses on the basic mechanisms of eccrine sweat secretion and its role in temperature regulation from Ayurveda as well as modern point of view followed by critical discussion of Ayurvedic concepts in the light of modern knowledge. Observations: In Ayurveda, collection, transportation and excretion of Sveda is under the regulation of Pita Dosh, Agni, Samana Vayu and Vyana Vayu through Svedavaha Srotas and Ambuvaha Srotas by Gati & Gyan. Scope and Limitations: This ayurvedic concept has revealed a clear and detail mechanism of temperature and appetite regulation by stomach, Rashdhatu and Lasika. They are taking an important role before the action of blood and sweating. The clinical trial should be done in future to make this concept completely valid.
A Novel Kind of Hermite Based Frobenius Type Eulerian Polynomials
Authors: Khan Waseem Ahmad , Nisar Kottakkaran Sooppy , Acikgoz Mehmet , Duran Ugur
Published: August 2019

We introduce a new kind of extended Hermite-based Frobenius type Eulerian polynomials and then derive diverse explicit and implicit summation equations including some symmetric formulas by utilizing series manupulation method. Multifarious summation formulas and identities given earlier for some well known polynomials such as Eulerian polynomials and Frobenius type Eulerian polynomials are generalized.
Effects of Congestion on Swarm Performance and Autonomous Specialization in Robotic Swarms
Authors: Hiraga Motoaki ,   Hiroshima University 1-4-1 Kagamiyama, Higashi-hiroshima, Hiroshima 739-8527, Japan, Ohkura Kazuhiro
Published: August 2019

This paper focuses on the effect of congestion on swarm performance by considering the number of robots and their size. Swarm robotics is the study of a large group of autonomous robots from which collective behavior emerges without reliance on any centralized control. Due to the fact that robotic swarms are composed of a large number of robots, it is important to consider the congestion among them. However, only a few studies have focused on the relationship between the congestion and the performance of robotic swarms; moreover, these studies only discuss the effect of the number of robots. In this study, experiments were conducted by computer simulation and carried out by varying both the number of robots and the size of the robots in a path formation task. The robot controller was designed with an evolutionary robotics approach. The results show that not only the number of robots but also their size are essential features in the relationship between congestion and swarm performance. In addition, autonomous specialization within the robotic swarm emerged in situations with moderate congestion.
Aprendiendo a interpretar el territorio: estudio de la fitotoponimia en la provincia de Salamanca
Authors: Fernández Álvarez Rubén , Gómez Gonçalves Alejandro , Luengo Ugidos Miguel Ángel
Published: August 2019

Uno de los recursos frecuentes en los análisis territoriales ha sido la toponimia. Esta nos ofrece una visión sobre las denominaciones que el ser humano ha otorgado al espacio. Entre los elementos utilizados para singularizar e individualizar el espacio en áreas reconocibles para la población, la vegetación ha sido uno de los más destacados. Los fitotopónimos pueden hacer alusión a especies vegetales que potencialmente podrían desarrollarse en esos lugares, o por el contrario estar refiriéndose a otras que por sus necesidades no tienen cabida. El presente trabajo se centra en la identificación de la correspondencia existente entre la vegetación potencial y los fitotopónimos localizados en los MTN50 que cubren la provincia de Salamanca. La correspondencia existente nos indica que nos encontramos ante un notable agente identificador, al menos, en este territorio.
Randomized controlled trial of laparoscopic cholecystectomy after ENGBD versus PTGBD in acute cholecystitis: the LCEVP study protocol
Authors: Mu Peilei , Yue Ping , Li Tianya , Bai Bing , Lin Yanyan , Zhang Jinduo , Wang Haiping , Liu Ying , Yao Jia , Meng Wenbo , Li Xun
Published: August 2019

Background Transitional drainage which is followed by cholecystectomy plays a key role in the management of acute cholecystitis, especially in high-risk surgical patients. Endoscopic naso-gallbladder drainage (ENGBD) is an alternative to percutaneous transhepatic gallbladder drainage (PTGBD) for patients who need temporary drainage. There is a lack of prospective comparison on the relevant outcomes of the two drainage methods during the period of drainage, especially the subsequent cholecystectomy.Methods This is a randomised controlled two arm double-blind singer center trial. Patients with acute cholecystitis undergo emergent or early cholecystectomy and need drainage will be randomly assigned to group PTGBD or ENGBD. Pain score is defined as the primary endpoint, whereas several secondary endpoints such as the rates of technical success, clinical remission, open conversion of cholecystectomy will be determined to elucidate more detailed differences between two groups. The general feasibility, safety and quality checks required for high quality evidence will be adhered to.Discussion This study would provide the first type A evidence concerning the comparison of ENGBD versus PTGBD in surgically high-risk patients with acute cholecystitis, it will be the first trial designed to determine the impact of two drainage methods on not only peri-drainage but also peri-LC.Trial registration NCT03701464. Registered on 10 Octomber 2018.
Factors associated with hemoglobin level of children 6-23 months of age in Wa Municipality of Ghana
Authors: Adokiya Martin Nyaaba , Langu Andrews T. K. , Ali Zakari
Published: August 2019

Background: Childhood anemia (hemoglobin <11.0g/dl) remains a key public health concern in sub-Saharan Africa including Ghana. Anemia in early childhood has consequences on the cognitive development and growth of children. We determined the factors associated with hemoglobin (Hb) level of children 6-23 months of age in the Wa Municipality of Ghana. Methods: A cross-sectional study was used involving 278 mother-child pairs selected from households using multi-stage sampling technique. Socio-demographic characteristics, nutritional knowledge on child feeding practices and antenatal care (ANC) attendance data were collected using questionnaires. Hb level was measured using an automated Huma Count 5L analyzer. Factors associated with Hb level was determined using linear regression modelling. Results: More than half (53.0%) of the children were females and aged more than one year (60.4%). The mean Hb was 8.5 ± 1.5 g/dl and prevalence of anemia (Hb <11.0 g/dl) was 95.0%. There was strong evidence for increased Hb level among children whose mothers had high nutritional knowledge (β=0.61, p<0.005) and those whose mothers attended ANC for at least four (4) times during pregnancy (β=0.42, p=0.04). We found some evidence for an association between sex of child (β=0.34, p=0.06), household wealth (β= -0.75, p=0.06) and Hb level. Conclusion: Anemia in children less than two years was high in the Wa Municipality. High maternal nutritional knowledge on child feeding and more ANC attendance were associated with increased hemoglobin level of children. We recommend that maternal education on child feeding practices during ANCs should be intensified by health workers.
The peptidyl-prolyl isomerases FKBP15-1 and FKBP15-2 negatively regulate lateral root development by repressing a vacuolar invertase in Arabidopsis
Authors: Wang Jun , Sun Wenjie , Kong Xiuzhen , Zhao Chunyan , Li Jianfu , Chen Yun , Gao Zhengyin , Zuo Kaijing
Published: August 2019

Background

Lateral root (LR) architecture determines the efficiency of nutrient absorption and anchors the plant. Internal auxin regulatory mechanisms that control the development of LR have been identiﬁed, but how external nutrients influence lateral root development remains elusive.

Results

We have characterized the functions of the FK506-binding proteins FKBP15-1 and FKBP15-2 in Arabidopsis. FKBP genes are mainly expressed in the vascular bundle of the root basal meristem region, and the FKBP proteins are localized to the endoplasmic reticulum. Co-IP and BIFC assays showed that FKBP15-1 and FKBP15-2 interact with the vacuolar invertase 2 (VIN2). Compared to Col-0 and the single mutants, the double mutant fkbp15-1fkbp15-2 had more LRs and LR initiation density, and possessed higher sucrose catalytic activity. Moreover, VIN2 can complement the phenotype of increased LRs in the fkbp15-1fkbp15-2 double mutant.

Conclusion

Our results indicate that FKBP15-1 and FKBP15-2 together participate in the control of LR numbers by regulating the enzyme activity of VIN2. Due to the activity of peptidylprolyl cis-trans isomerases owned by FKBP family proteins, our results provide a clue to further analysis the interplay between lateral root development and protein modification.
Hepatitis B Screening before Immunosuppressive Therapy: A statewide survey of current practice
Authors: Ali Ijlal Akbar , Hayat Maham , Fazili Javid , Chen Allshine , Zhao Daniel , Kanagala Rajesh , Abegunde Ayokunle
Published: August 2019

Background: Reactivation of Hepatitis B virus (HBVr) in patients on immunosuppressive therapy (IST) can be prevented by screening for HBV and preemptive antiviral therapy in patients with prior exposure. Some internal medicine (IM) subspecialty guidelines recommend screening for HBV in all patients prior to starting IST while other guidelines do not and there is no consensus.
Methods: We conducted a cross sectional survey to assess the current practice of IM sub-specialty physicians in Oklahoma regarding screening for HBV prior to starting IST.
Results: There were seventy respondents from different clinical practice settings; 47.2% (33/70) free-standing specialty clinic, 18.6% (20/70) university hospital/VA hospital, 12.9% (9/70) community hospital and 21.4% (15/70) private hospital. Gastroenterologists accounted for 34.3% (24/70), rheumatologists 25.7% (18/70), hematology-oncologists 21.4% (15/70), and dermatologists 18.6% (13/70). Mean number of years of clinical practice was 27.7(SD 11.9 years). The majority of respondents 91.4% (64/70) were aware of an existing guideline within their respective specialty about screening for HBV prior to prescribing IST. There was a statistically significant difference in practice by subspecialty regarding the choice of serological tests for HBV screening and practice regarding care of screening positive patients (P<0.05). Conclusion: There was significant variation in clinical practice regarding HBV screening, choice of HBV serological tests and management of screening positive patients. The extent to which our results are influenced by divergent subspecialty guidelines is unclear. However, it highlights an unmet need for physician education at IM sub-specialty level and a need for consensus on guidelines for prevention of HBVr.
Variations in utilization of health facilities for information and services on sexual and reproductive health among adolescents in South-East, Nigeria
Authors: Agu Ifunanya , Mbachu Chinyere , Ezenwaka Uchenna , Okeke Chinyere , Eze Irene , Agu Chibuike , Ndubuisi Mildred , Arize Ifeyinwa , Ikwuakor Chinyere , Ezumah Nkoli , Onwujekwe Obinna
Published: August 2019

[EXSCINDED]
Abstract

Background
Adolescents’ sexual and reproductive health have an important influence on a country’s long-term national growth. There is high level of burden due to poor adolescent sexual and reproductive health (ASRH) in Nigeria, especially Ebonyi state. Evidence shows that in Sub-Saharan Africa region, most adolescents experience poor access to information and other services relating to their sexual and reproductive health. Many cultures in Africa see matters around sex and sexuality as social taboos. This study aimed to access variations in utilization of health facilities for sexual and reproductive health information and services among adolescents in Ebonyi State, Nigeria. This will inform the design of interventions to improve ASRH.Methods

A total of 1057 in-school and out-of-school adolescents aged 13 to18 years were selected using cluster sampling of households from the 6 selected LGAs in this cross sectional survey. Structured questionnaires were used to collect data. Descriptive statistics was performed alongside stratification analysis. Tabulation, bivariate and multivariate logistic regression analysis were undertaken. A household wealth index was calculated using the total household consumption calculated divided by the number of people in the households (per capital household consumption). The per capita household consumption was used to categorize households into socio-economic quintiles. The variable was used to differentiate where key variables into socio-economic quintile equity analysis.Results

Majority of respondents had never visited any type of health facility to receive either SRH information (90.2%) or services (97.1%). Utilization rate of health facilities for SRH information was 9.8% while for other SRH services was 2.8%. Patent medicine vendor (PMV) was the most visited type of facility for SRH information and other services. Schooling is a strong predictor of health facilities’ utilization for SRH information (P<0.01) and other services (P<0.01).Conclusion

Utilization of health facilities for information and services among adolescents in Ebonyi State is very low and favourable towards informal service providers such as PMVs. Establishment and strengthening of the existing youth friendly centres, school clinics and occasional outreach programs designed specifically to target adolescents would perhaps improve adolescents’ access to adequate information and health facility utilization for sexual reproductive and health services.