bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Characterization, Anticancer and In Silico ADME Properties of Caproic Acid Derivatives against P388 Cancer Cell Lines
Authors: Widiyarti Galuh , Sundowo Andini , Megawati Megawati , Ernawati Teni
Published: July 2022

The in-silico properties of absorption, distribution, metabolism, and excretion (ADME) and drugs likeness of caproic acid ester derivativeswere evaluated. The esterification of caproic acid from palm kernel oil with sitronelol and geraniol from citronella oil has been carried out using base (NaOH) catalyst. The cytotoxicity of ester compounds were also tested against P388 murine leukemia cancer cell lines using MTT method. Analysis of the ester productswere carried outusing spectroscopic (IR, MS and 1H-NMR) methods, which were confirmed that the desired compounds were successfully synthesized. Caproic acid ester derivatives showed higher anticancer activity compared to the parent caproic acid for P388 cancer cell lines. Citronellyl caproate with IC50 4.15x10-2µM has the strongeractivity than geranyl caproate with IC50 11x10-2 µM.  ADME studies for the synthesized compounds revealed that the ester compounds have fulfill the Lipinski rule of five and has no carcinogenicity effect to rat or mouse.Key words: caproic acid, ester, P388, MTT, ADME
Effects of 7.2% hypertonic saline solution on cardiovascular parameters and endogenous arginine vasopressin secretion in euvolemic isoflurane-anesthetized horses
Authors: Schnuelle Megan L. , Hopster Klaus , Toribio Ramiro E. , Hurcombe Samuel D.
Published: July 2022

OBJECTIVE

To compare the effects of 7.2% hypertonic and 0.9% isotonic saline (sodium chloride) solutions on cardiovascular parameters and plasma arginine vasopressin (AVP) concentrations in healthy, isoflurane-anesthetized horses.

ANIMALS

8 healthy horses.

PROCEDURES

In a prospective, randomized, crossover study, horses were anesthetized with isoflurane twice with a 14-day washout period between anesthetic episodes. While anesthetized, horses received a bolus (4 mL/kg) of 7.2% hypertonic saline solution (HS) or 0.9% isotonic saline solution (IS). Heart rate; systolic, mean, and diastolic arterial blood pressures; and central venous and pulmonary artery pressures were measured every 5 minutes; cardiac output was measured by means of thermodilution every 15 minutes. Systemic vascular resistance (SVR) was calculated. Blood samples were collected before and during anesthesia, and plasma AVP concentrations were determined with a validated ELISA. Data were analyzed with repeated-measures ANOVA and Pearson correlations.

RESULTS

HS caused an increase in systolic (P = .003) and mean (P = .023) arterial blood pressures that lasted for 30 minutes. The SVR was increased (P < .001) for 45 minutes with HS compared with the SVR after IS administration. Mean plasma AVP concentration increased (P = .03) 15 minutes after HS administration, with the increase lasting 90 minutes.

CLINICAL RELEVANCE

A bolus of HS resulted in a clinically relevant increase in blood pressure in healthy, isoflurane-anesthetized horses. This effect was attributed to volume recruitment and an increase in SVR. Administration of HS offers an option for improving arterial blood pressure in anesthetized horses.
In vitro evaluation of surface characteristics comparing WaterLase (Biolase®) with tungsten carbide burs for composite removal: a pilot study
Authors: Alkandari Mohammed , Abela Stefan , Booth Alessandra , Bister Dirk
Published: July 2022

Introduction

The present ex-vivo study was designed to evaluate the surface roughness and analyse potential adhesive remnants on the enamel surface after composite removal using either an Er:YSGG WaterLase (WL) (Biolase®, Irvine, CA, USA) or a tungsten carbide (TC) bur (Alston, England, UK).

Methods

An in vitro study was designed using 21 extracted lower premolars. Pre-coated stainless steel brackets (3M Unitek, Monrovia, CA, USA) were bonded on all of the teeth except one, which served as a control. The teeth were allocated into two groups: Group 1 (n = 5), removal of composite with a TC bur. Group 2 (n = 15), removal of composite using the WL. Scanning electron microscope (SEM) imaging and Energy Dispersive X-ray Spectroscopy (EDS) were used to determine the surface roughness and atomic composition of the surfaces.

Results

Group 1 had a median damage depth of 17.6 µm with a range between 11.5 µ m and 28.7 µ m. Group 2 had a median damage depth of 166.3 µ m, with a range between 86.6 to 263.1 µ m. The depth differences between the two groups were statistically significant (p < 0.001, Mann–Whitney test). The atomic composition of the WL group was similar to sound enamel. The TC group showed a quantitative increase in carbon and silicone by 38.2% and 11.5%, respectively, a decrease in oxygen by 44.1% and an absence of phosphorous and calcium.

Conclusion

WL is efficient at removing composite from the enamel surface but could result in increased enamel surface roughness in comparison with conventional TC burs.
Evaluation of exaggerated claims in the abstracts of systematic reviews reporting accelerated orthodontic tooth movement: a meta research analysis
Authors: Shyagali Tarulatha R. , Rathore Ayesha , Kapoor Shanya , Gupta Abhishek , Tiwari Anil , Patidar Rahul
Published: July 2022

Background

The latest trend in scientific literature review is to scrutinise the practices of false or biased reporting of findings, which is rightly termed as ‘spin’. In recent years, accelerated tooth movement has gained attention from the orthodontic community, but the findings still remain unclear and controversial.

Objectives

To estimate the frequency of distorted claims and over-interpretation of abstracts of systematic reviews related to accelerated orthodontic tooth movement. The objective was to differentiate the type of claim and to determine its prevalence.

Methods

A literature search was performed using the Cochrane library and the top five most prominent orthodontic journals for systematic reviews on accelerated orthodontics were identified by applying appropriate key words. According to pre-set selection criteria, only systematic reviews published between January 2010 and September 2021 were included. The selected articles were scrutinised for the assigned exclusion criteria. The articles were finally scanned for false claims by two independent reviewers. The identified claims fell into either the categories of misleading interpretation, misleading reporting or misleading extrapolation. The obtained data were tabulated and analysed using the one-way ANOVA statistical test to indicate the difference between the different types of reported claims.

Results

There were 98 systematic reviews identified in total, of which 59 articles met the selection criteria and 39 articles were excluded. Of the 59 included articles, 38 systematic reviews had exaggerated claims. Twenty-two of the reported claims came under the misleading reporting category, 10 fell under the misleading interpretation category and 6 came under the misleading extrapolation category. The difference noted between the reporting prevalence of different types of claim was statistically significant (P < 0.001). In misleading reporting, it was noted that most of the systematic reviews refrained from reporting the adverse effects of treatment.

Conclusion

The prevalence of exaggerated claims is high in the abstracts of systematic reviews related to accelerated orthodontic tooth movement. It is recommended that a clinician critically assess the claims presented in systematic reviews which are considered to be the hallmark articles of evidence-based practice. Orthodontists should be careful when applying the findings in clinical practice.
Are regional airports economic effectiveness-oriented? Evidence from Poland
Authors: Chwiłkowska-Kubala Anna , Cyfert Szymon
Published: July 2022

Striving for a satisfactory level of effectiveness, managers must take actions aimed at achieving the set objectives and at reacting flexibly to changes that take place in the environment. They can do it by referring to the concept of dynamic capabilities that draw attention to a specific category of competences. Assuming that dynamic capabilities can be developed in any type of organisation, the article attempts to answer the question about the reasons for the differences in economic effectiveness of 13 Polish regional airports and 458 private enterprises. The results suggest that the category of economic effectiveness is important not only for private enterprises but also for regional airports. The findings reveal that the development of dynamic capabilities is conditioned not only by the period of the enterprise’s existence but also by the context of its operation, primarily the industry context.
Sharing and connecting information in the context of the Covid-19 pandemic and training skills for employees to meet the needs of businesses in digital transformation
Authors: Thi Hang , Nguyen Tran
Published: July 2022

In the context of the strong outbreak of the Covid-19 pandemic leading to increasing social distancing, it is difficult for businesses to access the labor market. Therefore, it is necessary to create a connection channel between the employer and the labor supplier. That helps to adapt to the context of the Covid-19 pandemic, while also taking advantage of the achievements from the Industrial Revolution 4.0. The development of a training model that connects human resource trainers with human resource users who are businesses is considered an important requirement in the context of the Covid-19 pandemic. The university-enterprise model demonstrates active cooperation and has a profound impact on teaching and scientific research activities in universities. Since then, constantly improving the quality of training to create labor products that meet the rigorous needs of enterprises. This study uses exploratory factor analysis methods to screen observations to analyze, evaluate and draw conclusions about the formation of a university-enterprise linkage model. Thereby helping to create a bridge in cooperation between universities and businesses. On that basis, propose solutions to promote cooperation between universities and businesses in the current Vietnamese conditions, contributing to creating high-quality labor for society, meeting the needs of digital businesses.
Do navigation maps need a legend? Empirical assessment of the intuitiveness of point symbols on mobile maps
Authors: Piątek Robert , Gołębiowska Izabela
Published: July 2022

Navigation applications and the mobile maps that are integral to them are now widely used all over the world. The most popular applications of this type, such as Google Maps, has more than a billion users a month. To save time, users of navigation applications generally use the maps without referring to their legends, which are not shown in the default settings. In such circumstances, only intuitive symbols are read correctly. Mobile maps often have an extensive system of point symbols (POIs – points of interests), and navigation applications sometimes differ significantly in the symbols they use. Point symbols have been the subject of theoretical considerations and empirical studies of users, but there is a lack of comparative research indicating more and less effective solutions for designing intuitive symbols on mobile maps. This article presents the results of empirical research on the intuitiveness of POI symbols used in selected navigation applications. The study was conducted in the form of a questionnaire with 127 respondents. The results confirmed the hypothesis that the analysed symbols used in navigation applications would differ in level of intuitiveness. In addition, features of design solutions that increase or decrease the intuitiveness of point symbols were identified.
Trends in treatment of childhood cancer and subsequent primary neoplasm risk
Authors: Cesen Mazic Maja , Reulen Raoul C. , Jazbec Janez , Zadravec Zaletel Lorna
Published: July 2022

Background

The aim of the study was to investigate long-term risk and spectrum of subsequent neoplasm (SN) in childhood cancer survivors and to identify how trends in therapy influenced cumulative incidence of SN.

Patients and methods

The population-based cohort comprises 3271 childhood cancer patients diagnosed in Slovenia aged ≤ 18 years between 1st January 1961 and 31st December 2013 with a follow-up through 31st December 2018. Main outcome measures are standardised incidence ratios (SIRs), absolute excess risks (AERs), and cumulative incidence of SN.

Results

After median follow-up time of 21.5 years for 5-year survivors, 230 patients experienced 273 SN, including 183 subsequent malignant neoplasm (SMN), 34 meningiomas and 56 nonmelanoma skin cancers. 10.5% patients received radiotherapy only, 31% chemotherapy only, 26.9% a combination of chemotherapy and radiotherapy and 16.1% surgery only. The overall SIR was almost 3 times more than expected (SIR 2.9), with survivors still at 2-fold increased risk after attained age 50 years. The observed cumulative incidence of SMN at 30-year after diagnosis was significantly lower for those diagnosed in 1960s, compared with the 1970s and the 1980s (P heterogeneity < 0.001). Despite reduced use of radiotherapy over time, the difference in cumulative incidence for the first 15 years after diagnosis was not significant for patients treated before or after 1995 (p = 0.11).

Conclusions

Risks of developing a SMN in this study are similar to other European population-based cohorts. The intensity of treatment peaked later and use of radiotherapy declined slower compared to high income countries, making continuous surveillance even more important in the future.
El papel del Parlamento en la mejora de la capacidad administrativa: evolución del control político de la administración y de su participación en el diseño y análisis de políticas públicas
Authors: Palau Roque Anna M. , Moreno Yaiza
Published: July 2022

La literatura enfatiza la importancia de reforzar la capacidad administrativa de los Estados para garantizar un uso eficiente de los fondos europeos. En el marco del Plan de Recuperación, Transformación y Resiliencia aprobado en España para distribuir los fondos europeos del programa Next Generation EU, este artículo analiza cómo puede el Parlamento español contribuir a mejorar esta capacidad administrativa. Se argumenta que puede contribuir en dos aspectos. En primer lugar, reforzando los mecanismos de rendición de cuentas del aparato administrativo. En segundo lugar, fomentando la participación de autoridades y funcionarios en el diseño y análisis de políticas públicas. Con el objetivo de explorar cómo el Parlamento ha desarrollado estas funciones, el artículo analiza la actividad de control parlamentario sobre las Administraciones Públicas entre 1979 y 2019, mediante el estudio de las preguntas orales introducidas en el Pleno y en Comisión. También se tienen en cuenta todas las comparecencias en Comisión de autoridades y funcionarios para el período 1986-2019. Los resultados muestran, por un lado, que el control político sobre las administraciones es bajo y, si bien se ha diversificado respecto a la década de los ochenta, ha disminuido de manera significativa a lo largo del tiempo. Por otro lado, la participación de autoridades y funcionarios en el diseño y análisis de políticas públicas, se circunscribe mayoritariamente a aspectos económicos y presupuestarios, y se desarrolla a través de cargos con un claro perfil político, más que técnico.
Género y Derechos Económicos, Sociales y Culturales
Authors: Cázares Sánchez Cristina
Published: July 2022

El género es una categoría transversal en los derechos económicos, sociales y culturales que permite construir un escenario de igualdad sustantiva para alcanzar un efectivo ejercicio de estos derechos humanos y mejorar la calidad de vida de este grupo vulnerable. Este artículo se refiere al género mujer, sin dejar de mencionar a la niña y la población LGTBI+ como también pertenecientes a la categoría género que padece una discriminación dentro del ejercicio de los DESC. A través de un recorrido legal, de opiniones consultivas de los órganos internacionales universales, específicos y regional interamericano y jurisprudencia de la región interamericana se presenta un escenario donde se identifica la urgencia de actuación desde las instituciones nacionales para la promoción de acciones afirmativas y políticas públicas que permitan alcanzar la igualdad en la protección de los derechos humanos de las mujeres.
La posible liberación de las patentes de vacunas para la Covid-19
Authors: Calderón García Jessica , Vaquier Ramírez Ricardo
Published: July 2022

El objetivo de este trabajo consistió en visibilizar la desigualdad entre países respecto al acceso de las vacunas para la Covid-19, así como exponer la colisión de los derechos a la propiedad intelectual y la salud, problema que obstaculizaría -en cierta medida- la liberación de las patentes; en paralelo, se atienden diversos conceptos básicos de la crítica al capitalismo de Marx, en el sentido de que, conforme a esa perspectiva, las vacunas son mercancías y los derechos fundamentales son simples buenas intenciones. La metodología utilizada se basó en la búsqueda, revisión y análisis de los ordenamientos, informes, estadística e investigaciones que contemplan la situación real de las muertes por la Covid-19, las vacunas existentes y aprobadas, los suministros adquiridos por países, así como la regulación de la propiedad intelectual y el derecho a la salud. Del análisis se desprendió que, para garantizar el acceso a la salud, debe contemplarse que estamos frente a una situación excepcional y las vacunas deben estar fuera del comercio, lo cual implica que las empresas farmacéuticas liberen sus fórmulas recibiendo una compensación adecuada -no excesiva-, por su descubrimiento. Ahora bien, a pesar de que existen vías legales para lograr la liberación de las vacunas, no se ha materializado, por lo tanto, no puede descartarse la viabilidad de la crítica Marxista al capitalismo y los derechos humanos, ya que, se prioriza la acumulación, aun cuando es evidente la emergencia sanitaria, menospreciando el derecho humano a la salud.
El patrimonio de familia en el Ejido Coatitila, Cofre de Perote
Authors: Huerta Lara María del Rosario
Published: July 2022

El presente ensayo tiene como objetivo analizar los efectos de las reformas jurídicas de 1992 al régimen agrario sobre los bienes afectos al patrimonio de la familia campesina, a la luz de las modificaciones que dichas reformas introdujeron al artículo 27 constitucional; En este sentido, se analiza el impacto que las mismas han producido específicamente en el Ejido de Coatitila, Veracruz, el cual, de acuerdo a las características constituye un centro de población del ámbito ejidal.
The Ideology and Policies of the State of Vietnam on Public Spaces
Authors: Van Tung Trinh
Published: July 2022

The concept of “public space” occasionally appears in legal documents of the State of Vietnam, especially in laws. On the contrary, in ordinary newspaper articles, “public space” is often mentioned under various terms including “public place”, “public location”, “public buildings”, etc. At the same time, public space falls in the scope of various aspects of interest, particularly urban public spaces. Thus, it is needed that the State's ideology and legal policies on public spaces are defined. Such challenge “suggests” that we analyze the currently available documents of previous researchers, searching in various regulatory documents of the State, as well as statistical documents and conducting in-depth interviews with urban planning experts to present an understanding of the State's ideology and legal policies on public spaces in Vietnam.

Various documents and researches have shown that the current planning policies in Vietnam consider land planning as a “golden mold” because the priority of the State still lies in economic, commercial, security and defense goals. These are the decisive factors that dominate other residential services, which is different from the modern logic of integrated planning, that, in turn, is based on three main pillars: i) Population planning and changes in demand for “residential services” in the broadest sense of this phrase (housing services; transportation services; medical services; educational services; cultural services; media services; environment, security and defense activities,...); ii) Administrative land planning; and iii) Land planning for economic and commercial activities. As a result of the current, yet simple categorization of land used in annual statistical documents, in the future, public space will not only be difficult to expand but also be narrowed in correlation with the growing population density, especially in urban areas. Meanwhile, the planning of public spaces of the previous periods still leaves us with lessons of the integrated and complex model to meet people's needs. The comparison of two French logic of integrated planning and the “socio-economic” spatial planning logic, taking economic and commercial in Anglo-Saxon-style as the central element also contributes to unravel the “ideology and policies of the planning of public spaces” of the state of Vietnam, although scientifically, the boundary between these two planning logic has now almost been blurred.

Keywords:

Public space planning; legal documents on public space planning; traffic space; spiritual space; entertainment and entertainment space; integrated logic; People's needs.
Evaluating the Level of Application of the Learning Organization Model in Enterprises in Kon Tum Province
Authors: Thi Thanh Truc Phan
Published: July 2022

The learning organization aims to create an open cultural environment in which employees self-study to improve their abilities while also support other colleagues in their development. The article conducted a survey of 204 employees at businesses in Kon Tum province and the results showed that psychological safety, respect for differences, openness to new ideas, time for reflection, education and training, information exchange, leadership reinforcement learning all ranked in the lowest group when compared to the standards of Harvard University. Towards this model, the article proposes a few solutions such as creating an open cultural environment where all employees can express their views openly, and it is necessary to introduce many policies to motivate employees to take initiative.
Identifying Barries in Implementing Policies on Human Resource Development for Social Work in Hospital Nowadays
Authors: Kim Khanh Ly Dang
Published: July 2022

Abstract: In 2020, the project “Development of social work as a profession in Vietnam for the 2010-2020 period” was considered the official beginning of social work profession in Vietnam. Then, the Ministry of Health developed social work models in hospitals based on the project “Development of social work as a profession in the health sector for the 2011-2020 period” according to Decision 2514/QD-BYT of the Ministry of Health dated July 15th, 2011. This is a new development in healthcare in Vietnam. To accompany the regular goal of improving the quality of medical services at health facilities of the health sector, social work in hospitals needs some changes for comprehensive development. The development of social work in hospitals, foremost, needs a system of professional social workers, both in quantity and quality, and appropriate policies which facilitate the implementation of social work models. The article described the current situation of social work development policies in general and social work in hospitals in particular, via analysis of policies on organizational structure, training and recruitment of social workers using survey data from two hospitals. From that, the paper identified obstacles in human resource development for social work in hospitals and proposed solutions to improve professional social work models at hospitals

Keywords

Social work, social work in hospitals, social work policy, human resource in social work.
Health Insurance Policies in Vietnam
Authors: Linh Mai
Published: July 2022

Among the social security system’s pillars, health insurance plays an important role in supporting people to enjoy medical examination and treatment and health care services. Health insurance is a form of community insurance applied in the field of medical examination and treatment and health care for all people. Since its creation, the health insurance system has been perfecting in terms of institution and policy in order to facilitate the implementation of healthcare services for the entire population, including people in need, people of ethnic minorities, people living in remote areas, people with disabilities, the elderly, children under 6, and people with chronic and hard-to-cure diseases... The article reviews a number of health insurance policies in Vietnam since 1992 and argues that Vietnam's health insurance policies have had many changes in the direction of being suitable for people's living conditions. In coming years, the goal of health insurance policies is to increase the coverage of health insurance to the entire population, especially to help those facing difficulties in society to get better health care and protection. The Law on Health Insurance, being organized and implemented by the State, has also been continuously adjusting with non-profit purpose. Accordingly, people are responsible to participate in accordance with the Law’s provisions.

Keywords

Health insurance, health insurance policies, Vietnam.
An Overview of Social Policies to Cope with the COVID-19 Pandemic in the World and in Vietnam
Authors: Thanh Truong Dao , Thu Huong Hoang , Thi Kim Nhung Nguyen
Published: July 2022

The emergence of the COVID-19 pandemic in the end of 2019 has significantly influenced people and nations worldwide. In order to cope with this pandemic, every country in the world has issued social policies to overcome the adverse effects of the pandemic on different social groups. By using the secondary data analysis and analysis of policy contents, this paper provided an overall picture of social policies in response to the COVID-19 pandemic in the world and Vietnam. The results showed a prompt reaction of the government in every country and in Vietnam in enacting policies on employment, health care, housing, insurance and other forms of social protection for different social groups who have been strongly affected by the COVID-19. However, those policies are not systematic and the target groups have not been adequate yet. Moreover, there is a lack of social policies to cope with the COVID-19 in the long run, especially after the lockdown period and in the “new normal situation” period. On that basis, the authors suggested several research topics that will be a helpful base for proposing the next social policies, which will be suitable for the new development stage of the pandemic, as well as for specific situations of each nation and area.

Keywords:

COVID-19 pandemic, social policies to cope with COVID-19, in the world, Vietnam.
A Proposal of Information Literacy Concept in Accordance with the Context of Higher Education in Vietnam
Authors: Xuan Huy Nghiem , Thi Thanh Huyen Bui
Published: July 2022

Information literacy is a type of personal capacity, which demonstrates an individual’s ability to master the information world, exploit and use information effectively to deal with his/her living, studying and working needs. Information literacy is associated with the development of lifelong learning capacity and social inclusion for individuals. Therefore, information literacy has become increasingly important, becoming a popular topic in education research, especially in the current context of the 4th Industrial Revolution. Since the 70s of the 20th century, information literacy has been widely discussed and developed by educational institutions, especially higher education ones, in Western countries. Concepts, theoretical frameworks and practices for developing information literacy for learners have been established and mostly applied in Western countries. However, with a different educational context, such as the one in Vietnam, how should information literacy for university students be conceptualized and developed? This paper firstly presents an overview of how the concept of information literacy has been changed globally and those aspects that impact the way information literacy has been conceptualized and developed. Key points discussed are educational context, academic culture, teaching and learning practices. From that analysis, the paper proposes a concept of information literacy for students, which is in accordance with the academic culture of Vietnamese higher education.
COVID-19: Context, Impact, Lessons Learned, Tourism Trends and Policy for Tourism-industry Recovery
Authors: Hong Long Pham , Viet Anh Ngo
Published: July 2022

COVID-19 is an infectious pandemic with far-reaching global consequences, affecting nearly every economic, cultural, social, and environmental area. The COVID-19 epidemic has wreaked havoc on the tourism sector, causing millions of people to lose their jobs and income all around the world. In order to assist the tourism industry to recover from the COVID-19 epidemic, Vietnam's tourism industry must acknowledge and re-evaluate tourism management and development. This research evaluated the economic, social, and environmental implications on the tourism industry worldwide and in Vietnam, as well as the Government of Vietnam's plans, policies, and strategies for safe adaptation and flexibility in reviving Vietnam's tourism business in the current circumstances. In addition, the report offers suggestions for reviving tourism.
MECHANISMS OF FORMATION OF INFOMEDIA LITERACY IN STUDENTS OF PEDAGOGICAL SPECIALTIES
Authors: YORDAN ANNA , MEDYNSKA OLESIA , SYNORUB HALYNA , OSOBA NATALIIA
Published: July 2022

The article is focused is on the features of the concept of modern education and the formation of competencies in students of higher education institutions. The specifics of training a future specialist in accordance with the challenges of society are analyzed. The necessity of developing critical thinking and media literacy in general is substantiated. The relevance of the functioning of Ukrainian media literacy projects is outlined. Emphasis is placed on the positive experience of implementation of the selective discipline “Information Media Literacy” for students of pedagogical specialties at Ternopil Volodymyr Hnatiuk National Pedagogical University.
We highlighted the competencies that are formed in the process of learning the elective course “Infomedia Literacy” for higher education students in the specialties of “Primary Education”, “Psychology”, “Geography”. A detailed description of the lesson on the topic “Verification of online content” is presented. The purpose of the lesson is to carry out a reasoned critical review of multimedia content, verify the authenticity of images, and identify manipulative materials. We substantiated the necessity of the use of critical thinking and analysis of media content on the subject of stereotyping, discrimination, hate speech in the course of the lesson “Hate speech in the media”. Effective pedagogical activities aiming at formation of media immunity of future specialists are illustrated.
Formation and development of digital ecosystems based on technological and telecommunication companies in Russia
Authors: Mamedov Murad Azer ogly , Mamedov Tural Fakhrad Ogly
Published: July 2022

The process of active digitalization plays an important role in solving a number of urgent tasks, and, in particular, in the field of finance. Together with the development of innovative information technologies and their implementation in all spheres of the economy, multiple optimization of the processes of rendering services, significant changes are observed not only in the types and methods of providing services, but also in general transformation of business models of operating economic entities. The object of research of this article is digital ecosystems based on technological and telecommunication companies. The subject of the research is the principles and models of functioning of digital ecosystems based on technological and telecommunication companies. The relevance of this study lies in the fact that in the conditions of universal digitalization, the boundaries of the services provided by the largest market participants are not only blurred, but their business models are also changing significantly. Within the framework of this study, the authors have revealed approaches to the definition of the concept of ecosystem. The analysis of the largest Russian digital ecosystems based on technology and telecommunications companies, and, in particular, their financial services, is carried out. The analysis was carried out on the basis of such digital ecosystems and their financial services as Yandex, VK Group and MTS. Conclusions are drawn based on the analyzed data and the author's forecasts about the further development of financial services of digital ecosystems based on technological and telecommunications companies are given.
Advances in immunotherapy for metastatic esophageal cancer
Authors: Darling H. S.
Published: July 2022

Conventionally, the treatment of metastatic esophageal carcinomas with cytotoxic chemotherapy has yielded very poor results. Recently, the incorporation of immune checkpoint inhibitors into the treatment landscape has produced promised results. This review highlights the landmark trials conducted in this area and brings out the relevant results which have changed or are likely to change the clinical practices among the oncologists.
A case of tracheal tumor with unusual bronchoscopic presentation: A case report
Authors: Ogunkoya John Omotola , Sanusi Michael
Published: July 2022

Primary tumor of the trachea and bronchial tree is rare. Primary tracheobronchial malignancies make up about 0.1% of all pulmonary tumors. The survival rate depends on several factors which include the malignant potential of the tumor, the patient’s comorbidities, and the location of the tumor. The index case is a 60-year-old woman who had 7 months history of globus with an associated history of central chest discomfort and cough of 3 months duration. There was a positive history of dysphagia to solid meals, odynophagia, dyspepsia, nausea, excessive belching, bloating, and regurgitation. These symptoms led to the diagnosis of gastroesophageal reflux disease. However, the persistent symptom of globus and worsening cough necessitated her referral to the chest clinic. Chest radiograph revealed opacity in the left upper lobe. Chest computerized tomographic scan showed a solitary, lobulated, and calcified soft-tissue mass in the apicoposterior segment of the left upper lobe with loss of volume. Bronchoscopy showed multiple planes of non-glistering submucosa lesions which were biopsied. The histology report revealed invasive adenocarcinoma of the airway. The surgical resection of tumors with stents was done and she was discharged home 2 weeks later. However, the patient refused adjunct chemotherapy. She is alive and well with complete resolution of symptoms. Early presentation, availability of investigative tools, and prompt treatment may improve survival in cases of trachea tumors as seen in the index case. A high index of suspicion is also needed to make a prompt diagnosis of trachea tumors, especially in patients presenting with globus.
REGULATION OF THE ECONOMIC SECURITY MANAGEMENT SYSTEM OF BUSINESS STRUCTURES
Authors:   Lviv University of Business and Law, Skrynkovskyy Ruslan , Kniaz Sviatoslav ,   Lviv Polytechnic National University, Tsyuh Svyatoslav ,   Lviv University of Business and Law, Rusyn-Hrynyk Roman ,   Lviv Polytechnic National University, Konovalyuk Iryna ,   Lviv Polytechnic National University, Starchenko Anton ,   Odesa National Economic University
Published: July 2022

The article proves that the regulation of the economic security management system of business structures is formed on the basis of eliminating deviations, shortcomings of its economic activity and improving the existing system to achieve previously set goals and objectives, certain purpose, results. It is noted that if the tasks chosen by the business structure cannot be fulfilled, and the goals are unattainable, unreasonable or not clearly formed, it is advisable to change the tasks or goals and rebuild the economic security management system of the business structure. Here we are talking about adjusting the goals and / or objectives aimed at development, taking into account the process and result, and towards effective management. Thus, the regulation of the economic security management system of a business structure in the face of fierce competition (competition) is the elimination of all shortcomings, deviations, problematic moments and weaknesses and the improvement of the interaction between the management and managed economic security systems in order to ensure the development of the business structure. The reasons for the irrational choice of strategies that will touch on the issues of regulation of the economic security management system of business structures are presented. It is proved that the decision to regulate the economic security management system of a business structure occurs when there are sufficient grounds for this. It is substantiated that the choice of goals and objectives should be carried out on the basis of a study of retrospective information, taking into account the assessment of the capabilities of the business structure, in order to achieve a certain and delivered goal, result. It has been determined that the results obtained do not always correspond to the potential of the business structure, since there are situations in practice when changes in the external environment or some factors of the internal environment of the business structure may not be taken into account for various reasons, and the capabilities of the business structure were underestimated or overestimated.
Quelques aspects de la communication verbale homme-chat
Authors: Rubi Serge
Published: July 2022

[Ce texte n'a pas de résumé].
A propos du psychodrame de groupe d'enfants
Authors: Traube Raymond , Gruber German
Published: July 2022

[Se référer au PDF pour le résumé].
Disponibilité sociale des représentations: approche linguistique
Authors: Gajo Laurent
Published: July 2022

This article aims to analyze through linguistic tools the social dimension of representations. The dynamics of social representations are viewed as the result of two processes: preconstruction and co-construction. More precisely, the notions of «social availability» and «reference-0» are developed and applied in a conversational analysis perspective. This study allows for a constrastive approach to the study of social representations within several sociopolitical contexts, notably the Aosta Valley (Italy) and the French-speaking part of Switzerland.
Métonymie dans la presse écrite: entre discours et langue
Authors: Lecolle Michelle
Published: July 2022

In this paper, I describe certain metonymies which are often employed in the daily French press. In these metonymies, a human being, or a set of individuals are referred to by means of the name of an institutional location: a capital city, a ministry in a Western country (Matignon, la Maison-Blanche…), the name of a country. These metonymic patterns don’t seem to be used by other speakers than journalists. However, they seem to be understood by them. Furthermore, certain facts indicate that they tend to be transformed into lexicalised tropes in journalistic language. However, they remain in an intermediate area between active and lexicalised trope. The point is that it is not possible, even in context to determine exactly what is denoted by means of metonymic terms. These metonymies construct fuzzy references to a set of persons (the head of the government, the government, its spokesmen, the state…). Therefore they are very useful to journalists: they can designate an entity very economically while remaining imprecise.
Images de la variation du français: dominantes et harmoniques, changements
Authors: Castellotti Véronique , Robillard Didier de
Published: July 2022

This article tries to gather knowledge about an ill-explored field: representations towards French in France. It discusses ways and means to produce empirical data on this subject. This data indicates that the field described above deserves investigation, as, alongside standard French, the other «parlures» sampled here produce a variety of different attitudes and representations. However hypothetical as these results may be considered (owing to the number of informants for example), they seem to depict informants anxious of social camouflage through language use. An interest towards meridional French appears as an important feature, as well mixed feelings towards samples of rural French.
Pratiques langagières, contextes d’interaction et genres de discours en logopédie / orthophonie
Authors: Weck Geneviève de
Published: July 2022

The article’s aim is to analyze the language practices from logopedic interventions, realized under dialogs. The frequent opposition between structured activities and spontaneous speech is criticized, and replaced by the notion of discourse heterogeneous dialog. The dialogs’ analyze is based on conversational analysis and discourse interactionism principles. 3 levels of dialogs’ management are distinguished: the management of interaction (turn takings, topics, conversational breakdowns, etc.), the management of discourse (ancorage, planification, textualization) and the verbal scaffolding (adults’ strategies, children’s reactions). Two examples of dialog between a speech therapist and a child are studied. They show the heterogeneousness of discourses produced by the interlocutors: many sequences and sub-sequences are highlighted.
Exalang – 5/8. Une batterie d’examen du langage oral et écrit chez l’enfant de 5 à 8 ans
Authors: Thibault Marie-Pierre , Helloin Marie-Christel , Croteau Bénédicte
Published: July 2022

This article presents a cognitive test battery for oral and written language. The fact that it is computerized gives it two advantages: performance time is measured precisely, and the results of each test are processed immediately. The complete battery is described, and tables regrouping groups of subtests are presented.
demandes de définition en français parlé. Aspects grammaticaux et interactionnels
Authors: De Stefani Elwys
Published: July 2022

This article aims to analyze a construction which is commonly described as an interrogative structure that speakers use to ask for a clarification of a comprehension problem. In spoken French, ça veut dire quoi? seems to be the most employed form when clarification is required. In many cases, the structure is followed or preceded by a constituent which is co-referential to the clitic ça, thus leading to a dislocated construction, such as ça veut dire quoi quinquennal? First, these forms – as well as similar expressions, like qu'est-ce que ça veut dire – will be analyzed with regards to their information structure (topic/focus). Thereafter, the emphasis is put on the functions which these constructions accomplish in interaction, whereby their sequential positioning as part of an adjacency pair (of the question-answer type) is taken into account. If in numerous cases the second part of the adjacency pair is expected to be ça veut dire…, in other cases the «answer»-part is expressed in another way. On these bases, the analysis will identify the different discourse tasks that speakers engaged in an interaction accomplish by using these forms.
Le(s) passé(s) surcomposé(s): temps, aspect, subjectivité
Authors: Sthioul Bertrand
Published: July 2022

The aim of this paper is to explore whether the French overcomposed past tense (passé surcomposé) has anything to do with the raise of subjective interpretations, that is, interpretations where it is necessary to represent the point of view of an allocentric subject. First, the main grammatical features of the overcomposed past in French are spelled out. Second, a discussion of the semantic literature is proposed, with an eye to diatopic variation, in particular to the usages of this form in French-speaking switzerland, where the overcomposed past is more common and endorses a wider set of semantic functions as well as a greater number of grammatical types than in standard French. It is then argued that, contrarily to what some have suggested in the literature, the overcomposed past in French cannot be analyzed as bearing subjective effects by itself.
Représentation mathématique du temps: après Reichenbach
Authors: Schwer Lipn Sylviane R.
Published: July 2022

This paper proposes an innovative way of modelising time with mathematical tools. Based on the classical formalism of Reichenbach and on the numerous linguistic approaches that endorse a Reichenbach-like relational-referential view, our formalism is taken from what is generally called S-languages. This model has three main advantages, which are advocated for in this paper, through a discussion of a number of linguistic approaches to time: The S-languages model i) captures the two fundamental relations of precedence and simultaneity, ii) allows to represent the discrete or continuous property of linguistic verbal objects, and iii) provides the algebraic operators required by temporal reasoning without recourse to a logically defined notion of 'time'.
situation de communication comme lieu de conditionnement du surgissement interdiscursif
Authors: Charaudeau Patrick
Published: July 2022

After we have specified why in this paper we will not make a distinction between the concepts of intertextuality and interdiscursivity, the author proposes to analyse this question in a socio-communicational discourse model within which first of all he will specify the basic parameters. Firstly, it is shown by an example that the interdiscursivity depends on an inference mechanism, and that the interpretation of a text demands multiple inferences. Secondly, this interdiscursivity mechanism is described through a triangular interconnectedness of "I – third person – You" around shared knowledge. This leads the author to the definition of "socio discursive imaginary". Finally, this interdiscursivity mechanism that rests on the socio-discursive imaginary is demonstrated on the basis of several examples taken from media discourse.
De la langue d'origine à la langue héritée : le cas des familles espagnoles à Bâle et à Genève
Authors: Merle Maud , Matthey Marinette , Bonsignori Cristina , Fibbi Rosita
Published: July 2022

This contribution is based upon the analysis of 36 interviews conducted with persons from 12 families belonging to three generations, based in Geneva (7 families) and Basel (5). Our aim was to verify whether a general tendency to assimilation would verify with the three generations model (Fishman, 1972). We found that just over a third of the migrants' grandchildren understand or speak the language of their grandparents, and that they are proud of it. Our data does not give evidence of any significant difference between male and female respondents in terms of willingness to transmit a particular language, but they do show the existence of strategies (in terms of matrimonial or childcare strategies) which favour the maintenance of Spanish, and also a difference between Basel and Geneva as regards attitudes towards plurilingualism. Indeed, in Geneva, where the maintenance of Spanish is more salient, attitudes towards plurilingualism are more favourable than in Basel.