bluuebunny/crossref_metadata_2025 huggingface dataset:
Improved Transformer-Based Deblurring of Commodity Videos in Dynamic Visual Cabinets
Authors: Huang Shuangyi , Liang Qianjie , Xie Kai , He Zhengfang , Wen Chang , He Jianbiao , Zhang Wei
Published: April 2024

In the dynamic visual cabinet, the occurrence of motion blur when consumers take out commodities will reduce the accuracy of commodity detection. Recently, although Transformer-based video deblurring networks have achieved results compared to Convolutional Neural Networks in some blurring scenarios, they are still challenging for the non-uniform blurring problem that occurs when consumers pick up the commodities, such as the problem of difficult alignment of blurred video frames of small commodities and the problem of underutilizing the effective information between the video frames of commodities. Therefore, an improved Transformer video deblurring network is proposed. Firstly, a multi-scale Transformer feature extraction method is utilized for non-uniform blurring. Secondly, for the problem of difficult alignment of small-item-blurred video frames, a temporal interactive attention mechanism is designed for video frame alignment. Finally, a feature recurrent fusion mechanism is introduced to supplement the effective information of commodity features. The experimental results show that the proposed method has practical significance in improving the accuracy of commodity detection. Moreover, compared with the recent Transformer deblurring algorithm Video Restoration Transformer, the Peak Signal-to-Noise Ratio of this paper’s algorithm is higher than that of the Deep Video Deblurring dataset and the Fuzzy Commodity Dataset by 0.23 dB and 0.81 dB, respectively.
Vienna Rectifier Modeling and Harmonic Coupling Analysis Based on Harmonic State-Space
Authors: Zhu Shiqi , Liu Junliang , Cao Yuelong , Guan Bo , Du Xiong
Published: April 2024

Due to the high permeability characteristics of power electronic devices connected to the distribution grid, the potential harmonic coupling problem cannot be ignored. The Vienna rectifier is widely utilized in electric vehicle charging stations and uninterruptible power supply (UPS) systems due to its high power factor, adaptable control strategies, and low voltage stress on power switches. In this paper, the three-level Vienna rectifier is studied, and the harmonic state-space (HSS) method is used to model the rectifier. The proposed model can reflect the harmonic transfer characteristics between the AC current and the DC output voltage at various frequencies. Finally, the model’s accuracy and the corresponding harmonic characteristics analysis are further verified by simulation and experimental test results. The results show that the harmonic state-space modeling used for Vienna rectifiers can reflect the harmonic dynamics of the AC and DC sides, which can be used in stability analysis, control parameter design, and other related fields.
Construction and Properties of Oil-Loaded Soybean Protein Isolate/Polysaccharide-Based Meat Analog Fibers
Authors: Zeng Xinyue , Cui Bing , Wu Di , Li Jing , Liang Hongshan , Zhou Bin , Li Bin
Published: April 2024

Rationally designing the fibrous structure of artificial meat is a challenge in enriching the organoleptic quality of meat analogs. High-quality meat analog fibers have been obtained by wet-spinning technique in our previous study, whereas introducing oil droplets will further achieve their fine design from the insight of microstructure. Herein, in this current work, oil was introduced to the soybean protein isolate/polysaccharide-based meat analog fibers by regulating the oil droplets’ size and content, which, importantly, controlled the spinning solution characterization as well as structure-related properties of the meat analog fiber. Results showed that the oil dispersed in the matrix as small droplets with regular shapes, which grew in size as the oil content increased. Considering the effect of oil droplets’ size and content on the spinnability of the spinning solution, the mechanical stirring treatment was chosen as the suitable treatment method. Importantly, increasing the oil content has the potential to enhance the juiciness of meat analog fibers through improvements in water-holding capacity and alterations in water mobility. Overall, the successful preparation of oil-loaded plant-based fiber not only mimicked animal muscle fiber more realistically but also provided a general platform for adding fat-soluble nutrients and flavor substances.
Chemical Profile and Biological Activities of Brassica rapa and Brassica napus Ex Situ Collection from Portugal
Authors: Serrano Carmo , Oliveira M. Conceição , Lopes V. R. , Soares Andreia , Molina Adriana K. , Paschoalinotto Beatriz H. , Pires Tânia C. S. P. , Serra Octávio , Barata Ana M.
Published: April 2024

This study aimed to analyse the chemical profile and biological activities of 29 accessions of Brassica rapa (turnips) and 9 of Brassica napus (turnips and seeds) collections, maintained ex situ in Portugal. HPLC-HRMS allowed the determination of glucosinolates (GLS) and polyphenolic compounds. The antioxidant and antimicrobial activities were determined by using relevant assays. The chemical profiles showed that glucosamine, gluconasturtiin, and neoglucobrassin were the most abundant GLS in the extracts from the turnip accessions. Minor forms of GLS include gluconapoleiferin, glucobrassicanapin, glucoerucin, glucobrassin, and 4-hydroxyglucobrassin. Both species exhibited strong antioxidant activity, attributed to glucosinolates and phenolic compounds. The methanol extracts of Brassica rapa accessions were assessed against a panel of five Gram-negative bacteria (Enterobacter cloacae, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar, and Yersinia enterocolitica) and three Gram-positive bacteria (Bacillus cereus, Listeria monocytogenes, and Staphylococcus aureus). The extracts exhibited activity against S. enterica and S. aureus, and two showed inhibitory activity against E. coli and Y. enterocolitica. This study provides valuable insights into the chemical composition and biological properties of Brassica rapa and Brassica napus collections in Portugal. The selected accessions can constitute potential sources of natural antioxidants and bioactive compounds, which can be used in breeding programs and improving human health and to promote healthy food systems.
The Role of Diet and Physical Activity in Shaping COVID-19 Severity: Design, Validation, and Application of a Retrospective Questionnaire
Authors: Vásquez-Aguilar Francisco , Vergara-Jiménez Marcela de Jesús , Figueroa-Salcido Oscar G. , Arámburo-Gálvez Jesús Gilberto , Cárdenas-Torres Feliznando Isidro , Ontiveros Noé , Martínez-López Erika , Barrón-Cabrera Elisa
Published: April 2024

After the global challenges posed by COVID-19, researchers strived to identify risk factors for severe cases, which lead to various complications—including death. Lifestyle modifications, such as implementing a healthy diet and recommended physical activity, have been shown to be protective against severe COVID-19 cases. Despite an association of a plant-based diet with reduced COVID-19 severity, specific dietary characteristics have not been identified. Also, the methodology for measuring physical activity is variable, with studies overlooking the intensity or the habit components of physical activity. To bridge this gap, our study designed, validated, and applied a retrospective questionnaire with aims of exploring the relationship between lifestyle factors, specifically diet and physical activity, and severe COVID-19. We considered the intensity and years of physical activity habit, which is a limitation of other questionnaires. Results reveal associations of age and BMI with severe COVID-19. An excessive sugar diet was found to be associated with severe COVID-19 and increased symptom duration. We also observed an inverse relationship pattern of moderate- and vigorous-intensity physical activity across case severity, which is absent in walking physical activity. This study lays a foundation for research aiming to identify lifestyle factors that prevent severe COVID-19 cases.
Relevance of the Get Active Questionnaire for Pre-Participation Exercise Screening in the General Population in a Tropical Environment
Authors: Ho Cuiying Lisa , Anantharaman Venkataraman
Published: April 2024

The Get Active Questionnaire (GAQ), developed by the Canadian Society for Exercise Professionals (CSEP), was recently recommended for pre-participation screening of the general population in Singapore before increasing their exercise levels. This literature review examines the evidence behind the GAQ and its relevance to our tropical environment. Searches were carried out via Pubmed, MEDLINE and the Cochrane Central Register of Controlled Trials. Resources referenced by the CSEPs were hand searched. The CSEP was also contacted for further information. The evidence behind each GAQ question was compared to international literature and guidelines, where applicable. Out of 273 studies, 49 were suitable for analysis. Two GAQ studies commissioned by the CSEP showed a high negative predictive value but high false negative rate. Of the nine GAQ questions, those on dizziness, joint pains and chronic diseases appear to be justified. Those on heart disease/stroke, hypertension, breathlessness and concussion require modification. The one on syncope can be amalgamated into the dizziness question. The remaining question may be deleted. No long-term studies were available to validate the use of the GAQ. Heat disorders were not considered in the GAQ. Modification of the GAQ, including the inclusion of environmental factors, may make it more suitable for the general population and should be considered.
Network Analysis of Sexual Well-Being in Women with Heart Failure: The Psychocardiological Perspective
Authors: Gerymski Rafał , Latusek-Mierzwa Maria
Published: April 2024

Sexuality is an important sphere of every person’s life. Sexual dysfunctions and sexual dissatisfaction may also be present in cardiac diseases. Individuals affected by heart failure (HF) deserve special attention since it can be the final stage of many cardiac diseases. Therefore, it is important to verify potential correlates of sexual well-being in individuals with HF. This study was conducted online between 2019 and 2023, and 262 Polish women aged between 18 and 59 years (M = 45.48; SD = 7.65) participated in it. The Short Sexual Well-Being Scale, Depression Anxiety and Stress Scale, Fatigue Assessment Scale, and authors’ questionnaire were used. Relationships between tested variables were verified with the use of network analysis performed with the EBICglasso estimator. Centrality assessment showed that sexual well-being had the highest values of betweenness, closeness and degree, followed by fatigue and depression measures. Sexual well-being was negatively related to the number of declared sexual dysfunctions, fatigue, stress and depression levels. Participants’ age and HF duration were not related to the sexual well-being of tested women. Multiple additional partial correlations were detected. The obtained results show that sexuality may be a central sphere of life in women with HF and that one’s sexuality should not be negated when working with cardiac patients.
Low Dietary Betaine Intake Is Associated with Increased Blood Cholesterol in Mexican Subjects
Authors: Ramos-Lopez Omar , Santuario-Loera Alma
Published: April 2024

Background: Betaine, an osmolyte derivative of the metabolite choline and the amino acid glycine, acts as a methyl donor in the conversion of homocysteine to methionine and is involved in the maintenance of adequate lipid metabolism. There is growing evidence for the role of betaine in the development of various lipid-related diseases, including dyslipidemia and cardiovascular risk. This study aimed to analyze associations between betaine intake and blood lipid profiles in Mexican subjects. Methods: A total of 212 adults were randomly recruited in the city of Tijuana, Baja California, Mexico. Betaine intake was estimated using Nutritionist Pro software. Body composition and metabolic measurements were obtained by conventional methods. In the total sample, the average intake of betaine was 14.32 mg/d. Individuals were categorized into three groups according to tertiles of betaine consumption: tertile/group 1 (<4.16 mg/d), tertile/group 2 (4.16–12.02 mg/d), and tertile/group 3 (>12.02 mg/d). Results: Compared to group 3, subjects within group 1 had higher serum levels of total cholesterol (p = 0.001), LDL-c (p = 0.026), and non-HDL-c (p = 0.021). In addition, significant negative Pearson correlations were found between betaine intake and the serum levels of total cholesterol (r = −0.432, 95% CI, −0.684, −0.185, p = 0.001), LDL-c (r = −0.370, 95% CI, −0.606, −0.134, p = 0.002), and non-HDL-c (r = −0.351, 95%CI, −0.604, −0.098, p = 0.007). Conclusions: Our results show that a low intake of betaine is associated with elevated blood cholesterol levels in Mexican subjects. On this basis, betaine consumption could be used as an additional dietary measure for cardiovascular care. However, additional studies are required to confirm our results in other Mexican regions as well as in other populations worldwide.
Transitioning to a Personalized Approach in Molecularly Subtyped Small-Cell Lung Cancer (SCLC)
Authors: Grenda Anna , Krawczyk Paweł , Obara Adrian , Gajek Łukasz , Łomża-Łaba Aleksandra , Milanowski Janusz
Published: April 2024

Lung cancer has become a major public health concern, standing as the leading cause of cancer-related deaths worldwide. Among its subtypes, small-cell lung cancer (SCLC) is characterized by aggressive and rapid growth, poor differentiation, and neuroendocrine features. Typically, SCLC is diagnosed at an advanced stage (extensive disease, ED-SCLC), with distant metastases, and is strongly associated with tobacco smoking and has a poor prognosis. Recent clinical trials, such as CASPIAN and IMpower133, have demonstrated promising outcomes with the incorporation of immune checkpoint inhibitors in first-line chemotherapy, leading to prolonged progression-free survival and overall survival in patients with ED-SCLC compared to standard chemotherapy. Other studies have emphasized the potential for future development of molecularly targeted therapies in SCLC patients, including inhibitors of IGF-1R, DLL3, BCL-2, MYC, or PARP. The molecular subdivision of SCLC based on transcriptomic and immunohistochemical analyses represents a significant advancement in both diagnostic and clinical approaches in SCLC patients. Specific molecular pathways are activated within distinct transcriptome subtypes of SCLC, offering the potential for personalized treatment strategies, such as targeted therapies and immunotherapies. Such tailored approaches hold promise for significantly improving outcomes in SCLC patients.
Novel Use of a Fibular Strut Allograft with Fibular Head in an Elderly Patient with Proximal Humeral Fracture and Severe Metaphyseal Comminution: An Alternative to Shoulder Arthroplasty
Authors: Lim Jun-Hyuk , Ahn Yeong-Seub , Kim Sungmin , Kim Myung-Sun
Published: April 2024

Treatment of a comminuted proximal humerus fracture (PHF) in elderly patients with severe osteoporosis is challenging, often leading to arthroplasty (such as hemiarthroplasty or reverse shoulder arthroplasty) as the treatment of choice. However, arthroplasty does not always guarantee favorable outcomes. In contrast, the use of intramedullary fibular strut allografts provides additional reduction stability during locking plate fixation; however, to our knowledge, there is limited literature on the use of fibular strut allografts, including the fibular head. Here we aim to report the advantages of using a fibular strut containing the fibular head in severe osteoporotic PHFs. We present the case of an 88-year-old female patient with severe osteoporosis diagnosed with a left PHF accompanied by severe metaphyseal comminution following a fall from a chair. Rather than shoulder arthroplasty, we performed osteosynthesis using a fibular strut allograft containing the fibular head. At the one-year follow-up after surgery, we observed excellent bony union and a favorable functional outcome without major complications, such as reduction loss. The novel use of a fibular strut allograft containing the fibular head could be promising for PHFs with severe metaphyseal comminution, potentially avoiding the need for arthroplasty.
Elastic Compression Dressing after Total Hip Replacement Slightly Reduces Leg Swelling: A Randomized Controlled Trial
Authors: Rohe Sebastian , Böhle Sabrina , Matziolis Georg , Layher Frank , Brodt Steffen
Published: April 2024

Background: Even minor adverse reactions after total hip replacement (THR), including lymphedema, postoperative leg swelling, and blood loss, compromise patient comfort in times of minimally invasive fast-track surgery. Compression dressings are commonly used in surgical practice to reduce swelling or blood loss. However, the use of spica hip compression dressings after primary THR is controversial, and prospective studies are lacking. Methods: We conducted a prospective, single-center, two-arm, randomized controlled trial (RCT) of patients undergoing THR for primary osteoarthritis. A total of 324 patients were enrolled; 18 patients were excluded, and 306 patients were finally analyzed. Leg swelling as primary endpoint was measured pre- and postoperatively with a rotating 3D infrared body scanner. Secondary endpoints were transfusion rate and blood loss, estimated by Nadler and Gross formulas. Results: Postoperative leg swelling was lower in the compression group (241 ± 234 mL vs. 307 ± 287 mL; p = 0.01), even after adjustment for surgery time and Body-Mass-Index (BMI) (p = 0.04). Estimated blood loss was also lower in the compression group on the first (428 ± 188 mL vs. 462 ± 178 mL; p = 0.05) and third (556 ± 247 mL vs. 607 ± 251 mL; p = 0.04) postoperative days and leveled off on the fifth postoperative day, but lost significance after adjustment for BMI and surgery time. Neither group received a transfusion. Conclusions: Compression dressing after THR in the context of minimally invasive surgery slightly reduces leg swelling, but has no effect on blood loss or blood transfusion rate. So, this method could not generally be recommended in primary hip replacement.
Evaluating the Efficacy of the Erector Spinae Plane Block as a Supplementary Approach to Cardiac Anesthesia during Off-Pump Coronary Bypass Graft Surgery via Median Sternotomy: A Randomized Clinical Trial
Authors: Kim Sujin , Song Seung Woo , Jeon Yeong-Gwan , Song Sang A. , Hong Soonchang , Park Ji-Hyoung
Published: April 2024

Background: Pain control after off-pump coronary artery bypass graft (OPCAB) facilitates mobilization and improves outcomes. The efficacy of the erector spinae plane block (ESPB) after cardiac surgery remains controversial. Methods: We aimed to investigate the analgesic effects of ESPB after OPCAB. Precisely 56 patients receiving OPCAB were randomly divided into ESPB and control groups. The primary outcome was visual analog scale (VAS) pain scores at 6, 12, 24, and 48 h postoperatively. Secondary outcomes were the dose of rescue analgesics in terms of oral morphine milligram equivalents, the dose of antiemetics, the length of intubation time, and the length of stay in the intensive care unit (ICU). Results: The VAS scores were similar at all time points in both groups. The incidence of severe pain (VAS score > 7) was significantly lower in the ESPB group (50% vs. 15.4%; p = 0.008). The dose of rescue analgesics was also lower in the ESPB group (19.04 ± 18.76, 9.83 ± 12.84, p = 0.044) compared with the control group. The other secondary outcomes did not differ significantly between the two groups. Conclusions: ESPB provides analgesic efficacy by reducing the incidence of severe pain and opioid use after OPCAB.
How Long Can You Delay? Curve Progression While Awaiting Vertebral Body Tethering Surgery
Authors: Regan Christina , Transtrum M. Bryant , Jilakara Bharadwaj , Milbrandt Todd A. , Larson A. Noelle
Published: April 2024

Background: The implications of delaying surgical intervention for patients with adolescent idiopathic scoliosis (AIS) wishing to undergo vertebral body tethering (VBT) have not yet been explored. It is important to understand how these delays can impact surgical planning and patient outcomes. Methods: This was a retrospective review that analyzed all AIS patients treated between 2015 and 2021 at a single tertiary center. Time to surgery from initial surgical consultation and ultimate surgical plan were assessed. Patient characteristics, potential risk factors associated with increased curve progression, and reasons for delay were also analyzed. Results: 174 patients were evaluated and 95 were scheduled for VBT. Four patients later required a change to posterior spinal fusion (PSF) due to excessive curve progression. Patients requiring PSF were shown to have significantly longer delays than those who received VBT. Additionally, longer delays, younger age, greater curve progression, and lower skeletal maturity were correlated with significant curve progression (≥5 degrees). Conclusions: Surgical delays for AIS patients awaiting VBT may lead to significant curve progression and necessitate more invasive procedures. Patients with longer delays experienced an increased risk of needing PSF instead of VBT. Of those requiring PSF, the majority were due to insurance denials. Optimizing surgical timing and shared decision-making among patients, families, and healthcare providers are essential for achieving the best outcomes.
JC Virus in Kidney Transplant Population: Are We Cautious Enough?
Authors: Pjanic Mirha , Aleckovic-Halilovic Mirna , Basic-Jukic Nikolina
Published: April 2024

The John Cunningham virus (JCV) is a polyomavirus that usually infects people at a young age and does not cause any symptoms in immunocompetent individuals. However, in immunocompromised individuals, such as kidney transplant recipients, JCV can cause severe and potentially fatal disease. Unfortunately, JCV has not been researched as extensively as the BK virus and is not mentioned in relevant kidney transplant guidelines. This lack of attention to JCV can lead to less consideration in kidney transplant patients’ care. Surveillance using locally available diagnostic methods is of the utmost importance. The presence of JCV can be diagnosed with urine decoy cells, viruria, or viremia verified by the PCR method. A low threshold for considering JCV as a possible cause of any neurological or renal dysfunction in kidney transplant recipients must be maintained. In such cases, kidney and brain biopsy are indicated. Maintaining the appropriate immunosuppression while avoiding over-immunosuppression to prevent JCV disease is crucial, and the approach should be individual, according to overall immunological risk. We hypothesize that the presence of the JCV can indicate overt immunosuppression and identify kidney transplant recipients more prone to opportunistic infections and diseases, including some malignancies. To explore that, future observational studies are needed.
A Comparison of Methods of Visual Census and Cryptobenthic Fish Collecting, an Integrative Approach to the Qualitative and Quantitative Composition of the Mediterranean Temperate Reef Fish Assemblages
Authors: Kovačić Marcelo , Glavičić Igor , Paliska Dejan , Soldo Alen , Valić Zoran
Published: April 2024

The present research quantitatively compared the fish composition among two methods for non-cryptic benthic fish species and one method for cryptobenthic fish species for the first time for the Mediterranean temperate reef fish assemblage. A visual census of fishes was performed within a cylinder of 4 m radius and within a cylinder of 2 m radius, while the cryptobenthic fishes were collected using a square of 1 m2 with anesthetic. The data and material were collected at fifty sampling points. The visual census methods together recorded 31 species, and the square with anesthetic method recorded 18 species. The quantitative comparison of methods of visual census and cryptobenthic fish collecting showed significantly different species richness, total fish abundance, and fish assemblage structure among methods. The applied methods were highly complementary. The cylinder of 2 m radius is well suited for epibenthic fishes and the cylinder of 4 m radius is reliable for hyperbenthic and benthopelagic fishes. Therefore, each of the methods well covered one of three components of ichthyobenthos (hyperbenthic, epibenthic, and cryptobenthic fishes), and all three methods together provided a far more complete assessment of fish species composition than any individual census method for the Mediterranean littoral benthic fishes.
The Impact of Immune System Aging on Infectious Diseases
Authors: Quiros-Roldan Eugenia , Sottini Alessandra , Natali Pier Giorgio , Imberti Luisa
Published: April 2024

Immune system aging is becoming a field of increasing public health interest because of prolonged life expectancy, which is not paralleled by an increase in health expectancy. As age progresses, innate and adaptive immune systems undergo changes, which are defined, respectively, as inflammaging and immune senescence. A wealth of available data demonstrates that these two conditions are closely linked, leading to a greater vulnerability of elderly subjects to viral, bacterial, and opportunistic infections as well as lower post-vaccination protection. To face this novel scenario, an in-depth assessment of the immune players involved in this changing epidemiology is demanded regarding the individual and concerted involvement of immune cells and mediators within endogenous and exogenous factors and co-morbidities. This review provides an overall updated description of the changes affecting the aging immune system, which may be of help in understanding the underlying mechanisms associated with the main age-associated infectious diseases.
Effect of the Drying Method and Storage Conditions on the Quality and Content of Selected Bioactive Compounds of Green Legume Vegetables
Authors: Gębczyński Piotr , Tabaszewska Małgorzata , Kur Katarzyna , Zbylut-Górska Maria , Słupski Jacek
Published: April 2024

This study aimed to determine the effect of the drying method (freeze-drying, air-drying), storage period (12 months), and storage conditions (2–4 °C, 18–22 °C) applied to two legume species: green beans and green peas. The raw and dried materials were determined for selected physical parameters typical of dried vegetables, contents of bioactive components (vitamin C and E, total chlorophyll, total carotenoids, β-carotene, and total polyphenols), antioxidative activity against the DPPH radical, and sensory attributes (overall quality and profiles of color, texture, and palatability). Green beans had a significantly higher content of bioactive components compared to peas. Freeze-drying and cold storage conditions facilitated better retention of these compounds, i.e., by 9–39% and 3–11%, respectively. After 12 months of storage, higher retention of bioactive components, except for total chlorophyll, was determined in peas regardless of the drying method, i.e., by 38–75% in the freeze-dried product and 30–77% in the air-dried product, compared to the raw material.
A Review of Quantitative and Topical Analysis of Anthocyanins in Food
Authors: Custodio-Mendoza Jorge A. , Aktaş Havva , Zalewska Magdalena , Wyrwisz Jarosław , Kurek Marcin A.
Published: April 2024

Anthocyanins, a subclass of flavonoids known for their vibrant colors and health-promoting properties, are pivotal in the nutritional science and food industry. This review article delves into the analytical methodologies for anthocyanin detection and quantification in food matrices, comparing quantitative and topical techniques. Quantitative methods, including High-performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS), offer precise quantification and profiling of individual anthocyanins but require sample destruction, limiting their use in continuous quality control. Topical approaches, such as Near-infrared Spectroscopy (NIR) and hyperspectral imaging, provide rapid, in situ analysis without compromising sample integrity, ideal for on-site food quality assessment. The review highlights the advancements in chromatographic techniques, particularly Ultra-high-performance Liquid Chromatography (UHPLC) coupled with modern detectors, enhancing resolution and speed in anthocyanin analysis. It also emphasizes the growing importance of topical techniques in the food industry for their efficiency and minimal sample preparation. By examining the strengths and limitations of both analytical realms, this article aims to shed light on current challenges and prospective advancements, providing insights into future research directions for improving anthocyanin analysis in foods.
Mediterranean-Type Diet Adherence and Body Mass Index through 20 Years of Follow-Up: Results from the ATTICA Cohort Study (2002–2022)
Authors: Damigou Evangelia , Georgoulis Michael , Chrysohoou Christina , Barkas Fotios , Vlachopoulou Elpiniki , Adamidis Petros S. , Kravvariti Evrydiki , Tsioufis Costas , Pitsavos Christos , Liberopoulos Evangelos , Sfikakis Petros P. , Panagiotakos Demosthenes
Published: April 2024

Evidence of the association between dietary habits and long-term body weight status is scarce. This study aimed to evaluate changes in Mediterranean-type diet (MTD) adherence in relation to body weight during 20 years of follow-up. Data from n = 1582 participants from the ATTICA cohort study (2002–2022) were used. MTD adherence was assessed via MedDietScore, and body weight status via body mass index (BMI) by 3 different measurements. We found that MTD adherence and changes in this adherence were inversely related to BMI at 20 years and the mean BMI during the 20-year follow-up. In multi-adjusted linear regression models, a 1/55 increase in baseline, 10-year, and 20-year MedDietScore was associated with a decrease of 0.05–0.13 kg/m2 in BMI at 20 years and of 0.08–0.09 kg/m2 in the mean BMI. Being consistently close to the MTD for 20 years was associated with a >90% decreased risk of maintaining overweight/obesity during the 20-year period. Strong, protective, long-lasting effects of the MTD were observed, even in those who deviated from the MTD in the follow-up (41% of the sample). Our results highlight the need to focus on the overall diet quality to minimize the risk of maintaining an excessive body weight during the life-course.
The Frequency of Porcine Cysticercosis and Factors Associated with Taenia solium Infection in the Municipality of Tuchín-Córdoba, Colombia
Authors: Arango-Londoño Margarita M. , López-Osorio Sara , Rojas-Bermudéz Fernando , Chaparro-Gutiérrez Jenny J.
Published: April 2024

Taeniasis and cysticercosis are parasitic infections that affect humans and pigs. Their global distribution constitutes a serious public health issue with significant implications for pork production. The purpose of this study was to evaluate the presence of porcine cysticercosis in backyard swine from 42 indigenous communities throughout Tuchín-Córdoba, Colombia. Between December 2020 and March 2021, free-range pigs (n = 442) were assessed using the ELISA cysticercosis Ag test; 85 pigs were examined through sublingual visual evaluation, and 4 slaughtered pig carcasses were subjected to standard operation inspection. The collected cysticercus underwent histological and PCR analysis. Furthermore, 192 surveys of knowledge, attitudes, and practices (KAP) were used to identify the factors that facilitate infection transmission. Serological investigation revealed that 9.7% (46/472) of the animals were positive for cysticerci Ag. Sublingual inspection identified cysticercus in 28.7% (25/87) of the animals, while PCR analysis indicated that cysticercus corresponded to the T. solium American/African genotype. The factors associated with T. solium infection in the pigs in the surveyed areas numbered 14. The majority are associated with factors that promote the active persistence of Taenia solium’s life cycle in an area, such as lack of environmental sanitation, a lack of coverage or care for drinking water and wastewater treatment services, and no solid waste disposal.
Effects of Long-Term Controlled-Release Urea on Soil Greenhouse Gas Emissions in an Open-Field Lettuce System
Authors: Wang Xuexia , Cao Bing , Zhou Yapeng , Zhao Meng , Chen Yanhua , Zhang Jiajia , Wang Jiachen , Liang Lina
Published: April 2024

Controlled-release urea (CRU) fertilizers are widely used in agricultural production to reduce conventional nitrogen (N) fertilization-induced agricultural greenhouse gas emissions (GHGs) and improve N use efficiency (NUE). However, the long-term effects of different CRU fertilizers on GHGs and crop yields in vegetable fields remain relatively unexplored. This study investigated the variations in GHG emissions at four growth stages of lettuce in the spring and autumn seasons based on a five-year field experiment in the North China Plain. Four treatments were setup: CK (without N application), U (conventional urea—N application), ON (20% reduction in urea—N application), CRU (20% reduction in polyurethane-coated urea without topdressing), and DCRU (20% reduction in polyurethane-coated urea containing dicyandiamide [DCD] without topdressing). The results show that N application treatments significantly increased the GHG emissions and the lettuce yield and net yield, and DCRU exhibited the lowest N2O and CO2 emissions, the highest lettuce yield and net yield, and the highest lettuce N content of the N application treatments. When compared to U, the N2O emission peak under CRU and DCRU treatments was notably decreased and delayed, and their average N2O emission fluxes were significantly reduced by 10.20–20.72% and 17.51–29.35%, respectively, leading to a significant reduction in mean cumulative N2O emissions during the 2017–2021 period. When compared to U, the CO2 fluxes of DCRU significantly decreased by 8.0–16.54% in the seedling period, and mean cumulative CO2 emission decreased by 9.28%. Moreover, compared to U, the global warming potential (GWP) and greenhouse gas intensity (GHGI) of the DCRU treatment was significantly alleviated by 9.02–17.13% and 16.68–20.36%, respectively. Compared to U, the N content of lettuce under DCRU was significantly increased by 6.48–17.25%, and the lettuce net yield was also significantly increased by 5.41–7.71%. These observations indicated that the simple and efficient N management strategy to strike a balance between enhancing lettuce yields and reduce GHG emissions in open-field lettuce fields could be obtained by applying controlled-release urea containing DCD without topdressing.
Integration of Metabolomic and Transcriptomic Analyses Reveals the Molecular Mechanisms of Flower Color Formation in Prunus mume
Authors: Wang Ruyi , Yang Xin , Wang Tao , Li Baohui , Li Ping , Zhang Qin
Published: April 2024

Flower color is an important trait that affects the economic value of Prunus mume, a famous ornamental plant in the Rosaceae family. P. mume with purple–red flowers is uniquely charming and highly favored in landscape applications. However, little is known about its flower coloring mechanism, which stands as a critical obstacle on the path to innovative breeding for P. mume flower color. In this study, transcriptomic and targeted metabolomic analyses of purple–red P. mume and white P. mume were performed to elucidate the mechanism of flower color formation. In addition, the expression patterns of key genes were analyzed using an RT-qPCR experiment. The results showed that the differential metabolites were significantly enriched in the flavonoid synthesis pathway. A total of 14 anthocyanins emerged as the pivotal metabolites responsible for the differences in flower color between the two P. mume cultivars, comprising seven cyanidin derivatives, five pelargonium derivatives, and two paeoniflorin derivatives. Moreover, the results clarified that the metabolic pathway determining flower color in purple–red P. mume encompasses two distinct branches: cyanidin and pelargonidin, excluding the delphinidin branch. Additionally, through the integrated analysis of transcriptomic and metabolomic data, we identified 18 key genes responsible for anthocyanin regulation, thereby constructing the gene regulatory network for P. mume anthocyanin synthesis. Among them, ten genes (PmCHI, PmGT2, PmGT5, PmGST3, PmMYB17, PmMYB22, PmMYB23, PmbHLH4, PmbHLH10, and PmbHLH20) related to anthocyanin synthesis were significantly positively correlated with anthocyanin contents, indicating that they may be the key contributors to anthocyanin accumulation. Our investigation contributes a novel perspective to understanding the mechanisms responsible for flower color formation in P. mume. The findings of this study introduce novel strategies for molecular design breeding aimed at manipulating flower color in P. mume.
Integration of Renewable Energy Systems in Desalination
Authors: Al-Obaidi Mudhar A. , Alsadaie Salih , Alsarayreh Alanood , Sowgath Md. Tanvir , Mujtaba Iqbal M.
Published: April 2024

Desalination plants, which provide drinking water for residents, rely on electricity generated by fossil fuels. However, the excessive use of fossil fuels leads to their rapid depletion and has detrimental effects on the environment. Thus, the use of renewable energy resources in water desalination has gained popularity. The current research investigates the integration of renewable energy systems with seawater and brackish water desalination technologies. In this regard, three primary renewable energy sources—wind, solar, and geothermal—are selected. Accordingly, a thorough investigation of the related research published and the trend of evolutions between 2013 and 2023 is carried out for Reverse Osmosis (RO), Multistage flash (MSF), and Multi-effect distillation (MED)-based water desalination facilities coupled with renewable energy sources. In our investigation, we particularly focus on performance indicators, energy efficiency, economic factors, and environmental effects. Also, the associated challenges of these hybrid systems, such as technological complexity, unpredictability, and intermittency, are addressed. Prospects for the future that address these issues and the prospects of using renewable energy in water desalination technologies are also covered.
Digital Self-Interference Canceler with Joint Channel Estimator for Simultaneous Transmit and Receive System
Authors: Song Shiyu , Tang Yanqun , Lu Xianjie , Zhou Yu , Wei Xizhang , Wang Zhengpeng , Ge Songhu
Published: April 2024

Simultaneous transmit and receive wireless communications have been highlighted for their potential to double the spectral efficiency. However, it is necessary to mitigate self-interference (SI). Considering both the SI channel and remote transmission (RT) channel need to be estimated before equalizing the received signal, we propose two adaptive algorithms for linear and nonlinear self-interference cancellation (SIC), based on a multi-layered joint channel estimator structure. The proposed algorithms estimate the RT channel while performing SIC, and the multi-layered structure ensures improved performance across various interference-to-signal ratios. The M-estimate function enhances the robustness of the algorithm, allowing it to converge even when affected by impulsive noise. For nonlinear SIC, this paper introduces an adaptive algorithm based on generalized Hammerstein polynomial basis functions. The simulation results indicate that this approach achieves a better convergence speed and normalized mean squared difference compared to existing SIC methods, leading to a lower system bit error rate.
Unveiling Extramedullary Hematopoiesis: A Case Report Highlighting the Causes, Symptoms, and Management Strategies
Authors: Manganas Konstantinos , Xydaki Aikaterini , Kotsiafti Angeliki , Papakonstantinou Olympia , Delicou Sophia
Published: April 2024

Extramedullary hematopoiesis (EMH) serves as a compensatory mechanism in chronic hemolytic anemias, such as thalassemia, and can result in spinal cord compression. This case report highlights a 36-year-old woman with transfusion-dependent β-thalassemia (TDT) who presented with lower extremity motor deficiency, pelvic paresthesia, and bladder dysfunction. The patient had a history of lower back pain, bilateral lower limb weakness, and demonstrated poor compliance with iron chelation therapy. MRI findings indicated spinal cord compression attributable to extramedullary hematopoiesis. Due to the infeasibility of surgical intervention, the patient underwent hypertransfusion and iron chelation therapy. While neurological symptoms improved, urinary retention persisted. The patient continues to receive iron chelation treatment and undergo transfusions. Managing extramedullary hematopoiesis in thalassemia necessitates an individualized treatment approach.
Minimal Determinants for Lifelong Antiviral Antibody Responses in Mice from a Single Exposure to Virus-like Immunogens at Low Doses
Authors: Wholey Wei-Yun , Meyer Alexander R. , Yoda Sekou-Tidiane , Chackerian Bryce , Zikherman Julie , Cheng Wei
Published: April 2024

The durability of an antibody (Ab) response is highly important for antiviral vaccines. However, due to the complex compositions of natural virions, the molecular determinants of Ab durability from viral infection or inactivated viral vaccines have been incompletely understood. Here we used a reductionist system of liposome-based virus-like structures to examine the durability of Abs from primary immune responses in mice. This system allowed us to independently vary fundamental viral attributes and to do so without additional adjuvants to model natural viruses. We show that a single injection of protein antigens (Ags) orderly displayed on a virion-sized liposome is sufficient to induce a long-lived neutralizing Ab (nAb) response. The introduction of internal nucleic acids dramatically modulates the magnitude of Ab responses without an alteration of the long-term kinetic trends. These Abs are characterized by very slow off-rates of ~0.0005 s−1, which emerged as early as day 5 after injection and these off-rates are comparable to that of affinity-matured monoclonal Abs. A single injection of these structures at doses as low as 100 ng led to lifelong nAb production in mice. Thus, a minimal virus-like immunogen can give rise to potent and long-lasting antiviral Abs in a primary response in mice without live infection. This has important implications for understanding both live viral infection and for optimizing vaccine design.
Implementation of the meaning-formimg and organizing functions of the texture in the piano works of modern Ukrainian composers
Authors: Jing Yang
Published: April 2024

Statement of the problem. Recent research and publications. Today the texture of a music work is not only a marker of an epochal style, but also, more than ever, of an individual style. Studying the principles of textural organization, understanding the specifics of the action of textural functions gives the performer the keys to deciphering the artistic intent of the work, the system of the composer’s style and finding the corresponding performance techniques. And in the conditions of the complex genre system of modern music, the texture is able to carry out the function of an interpretative guide to the heart of the composer’s idea, the author’s concept. The scientific works by such musicologists as H. Vinohradov (1977), I. Denysenko (2010), H. Ihnatchenko (1984), R. Kashyrtsev (2021), V. Moskalenko, V. Prykhodko (1997), H. Savchenko (2023), I. Tsurkanenko (1998), M. Chernyavska (2015a; 2015b), S. Shyp (1998), S. Shkoliarenko (2017) are devoted to the study of musical texture. A panoramic understanding of the development vectors of the doctrine of texture in the works of Ukrainian scientists can be found in the article by O. Hnatyshyn (2015). Objectives, methods, and novelty of the research. The purpose of the article is to reveal the ways of realizing the meaning-forming function of the texture based on the analysis of piano works by modern Ukrainian composers: Serhii Piliutykov’s “Fairy Tale” and Zoltan Almashi’s “Elegy”. The stylistic, genre, systematic and functional methods of researching are used in the article. For the first time in Ukrainian musicology, the selected works are analyzed from the point of view of textural organization. Results and conclusion. The situation of the gap the connection between the genre and the texture actualizes the meaning-forming and organizing function of the texture. S. Piliutykov in “Fairy Tale” builds a meaningful multilayered structure horizontally and vertically, working with different stylistic thematic elements, thereby revealing the programmatic idea. As a result, a specific musical narrative is created, which is unfolded in the interaction of vertical and horizontal texture layers. In “Elegy” by Z. Almashi, the principles of textural organization chosen by the composer seem to push the boundaries of the genre, provide for a different timbre embodiment, and timbre-texture transformations become decisive in building the composition in time and space.
Upstarts T3: An Asynchronous and Cohort-based Entrepreneurship Train-the-Trainer Program
Authors: Kim Surin , de Guzman Maria , Do Kieu-Anh , Padasas Irene , Nicholas Claire , Kennedy Olivia , Erdmann Anna , Larson Andy
Published: April 2024

UpStarts is a reverse-mentoring youth program designed to foster an entrepreneurial mindset among participants and a sense of connection between youth and adults. Effective facilitators are critical to the success of the program. This paper describes an asynchronous, cohort-based virtual train-the-trainer (T3) program for potential UpStarts facilitators that was developed to navigate the challenges posed by the COVID pandemic. Participants of the initial UpStarts T3 program reported positive feedback for the training and a high sense of efficacy in implementing UpStarts in their communities. The current T3 model is emerging as a promising means of preparing facilitators to implement UpStarts.
Factors Affecting Honey Bee (Apis mellifera L.) Health as Perceived by South Georgia Commercial Beekeepers
Authors: Post Kimberly
Published: April 2024

Honey bees (Apis mellifera L.) are critical to the pollination of many crops. Bee-oriented organizations survey beekeepers annually to gather information about colony loss and contributing factors. Unfortunately, these surveys provide insufficient data from sideliner and commercial beekeepers in Georgia. Through a survey to better understand South Georgia beekeepers’ perceptions of honey bee health, this project engaged a previously underrepresented group of sideliner and commercial beekeepers.
Evaluation of the Michigan Water School: Water Education Program for Local Leaders
Authors: Triezenberg Heather , Hunnell Jennifer , Elgin Erick , Bhakta Bindu , Bohling Mary
Published: April 2024

Local leaders are essential for helping Michigan achieve its 30-year water strategy goals. The Michigan Water School is an Extension nonformal educational program to address the knowledge gap of local leaders. We evaluated programs conducted from 2017-2019. Results revealed program outcomes in knowledge, attitudes, perceptions of criticalness to work, and stewardship and behavioral intentions aligned to water quality, water quantity, and field experience units. Growth areas for program improvement include water policy, economics, planning, and finance as well as expanding the focus of the program for transformational leadership and to broaden recruitment efforts.