bluuebunny/crossref_metadata_2025 huggingface dataset:
Monolithic and heterogeneous three-dimensional (3D) integration of two-dimensional (2D) materials using dense vias
Authors: Das Saptarshi , Ghosh Subir , Zheng Yikai , Zhang Zhiyu , Sun Yongwen , Schranghamer Thomas , Sakib Najam U , Chen Chen , Redwing Joan , Yang Yang
Published: December 2023

The semiconductor industry is experiencing a tectonic shift with the adoption of three-dimensional (3D) integration, enabling the convergence of various technologies, such as analogue, radio frequency, sensors, memory devices, and digital components. Historically, through-silicon via (TSV) stacking has been the dominant approach to 3D integration, leading to the commercialization of 3D-stacked CMOS image sensors, 3D flash memories, and dynamic random-access memory (DRAM) stacks. While TSV technology can achieve impressive interconnect (I/O) densities of up to 10,000 I/O per mm², further improvement requires the adoption of monolithic 3D integration (M3D). M3D also enables transistor-level partitioning and material heterogeneity. However, widespread use of non-silicon materials in M3D is pending. In this study, we showcase heterogeneous M3D integration using all-two-dimensional (all-2D) materials, achieving an interconnect density of 40,000 I/O per mm² with more than 500 devices in each tier. Additionally, our manufacturing process stays below 200°C, which is ideal for back-end-of-line (BEOL) integration. The M3D stack in our study includes graphene-based chemisensors in tier 2 and MoS2 memtransistor-based programmable circuits in tier 1, tailored for near-sensor computing applications. A notable achievement in our work is the physical proximity between sensors and computing elements, which is less than 100 nm. This proximity far surpasses what is currently achievable with state-of-the-art packaging solutions. Our results mark a significant milestone in vertically stacked functional layers composed of heterogeneous materials beyond silicon for edge applications.
Effects of Gas-Tungsten Arc Welding on the Mechanical Properties and Microstructure of 316L Stainless Steel by Powder Bed Fusion
Authors: Kuehn Kevin , Wang Xuan
Published: December 2023

This paper investigates the weldability of stainless steel 316L and tensile behavior of welded samples, comparing in samples produced through powder bed fusion (PBF) and the conventional wrought method. Tensile testing is performed on each welded combination of materials (PBF-PBF, wrought- wrought, and PBF-wrought). Results suggest that the wrought material exhibits higher tensile strength and uniform elongation point, while displaying a lower yield stress compared to the PBF material. Additionally, welded wrought samples have a significantly lower tensile strength compared to non-welded samples. The wrought samples exhibit a larger average grain size in the heat affected zone (HAZ) compared to non-heat affected regions. In contrast, it is found that grain coarsening does not occur in PBF samples, which exhibit a significantly smaller grain size in the HAZ than the wrought samples. The average grain size in the non-heat affected zone is larger for the PBF samples compared to the wrought samples. Larger grain sizes within the HAZ correspond to a reduction in tensile strength and uniform elongation point for the wrought samples, compared to PBF samples. However, no such reduction is observed for the PBF samples. Secondary dendrite arm spacing measurements indicated similar solidification behavior in the weld regions of both PBF and wrought materials. Overall, the PBF samples exhibit less reduction of strength and ductility after welding than wrought samples. Therefore, it is determined that additively manufactured 316L stainless steel has a higher weldability than traditionally manufactured wrought 316 stainless steel.
Effect of different continuous cropping years on the rhizosphere soil microbial community structure of Tussilago farfara L.
Authors: Xia WANG , Xiaojun JIN
Published: December 2023

The rhizosphere soils from 1, 2, and 3 years of Tussilago farfara L. continuous cropping were used as the research objects. The region of bacterial 16S rRNA and fungal ITS was analyzed by Illumina MiSeq high-throughput sequencing technology. The effect of continuous cropping years on the microbial community structure and diversity in Tussilago farfara L. soil was investigated. The result shows that rhizosphere soil fast-acting nutrient content, alkaline phosphatase, and sucrase activity gradually decreased, urease activity increased first and then decreased, and catalase activity did not change significantly with the increase of cropping years. The number and diversity of rhizosphere soil bacteria increased first and then decreased, while the fungal species increased by 22.5% after continuous cropping for two years compared with rotational cropping. Among the bacteria, the relative abundance of Proteobacteria and Acidobacteria decreased significantly after continuous cropping, and the relative abundance of Actinobacteria and Chloroflexi increased; among the fungi, the relative abundance of Ascomycota and Basidiomycota decreased significantly after continuous cropping, while the relative abundance of Mortierellomycota increased. The population type gradually changed from bacterial to fungal, and the relative abundance of beneficial genera such as Ralstonia, Nitrospira, and Trichoderma gradually decreased, while harmful genera such as Mortierella, Fusarium, and Tricharina accumulated in large quantities. This study reflects the dynamic balance of rhizosphere soil bacterial-fungal communities of Tussilago farfara L. in different continuous cropping years, and the changes of nutrient content, enzyme activity, and genera reflect the possible genera associated with the occurrence of cropping obstacles of Tussilago farfara L., as well as the relevant groups of bacteria to maintain the stability of microbial communities, which provides a scientific reference basis for further investigation of cropping obstacles and screening of beneficial genera.
Effect of repetitive transcranial magnetic stimulation on upper limb motor function in stroke patients with right hemiplegia based on EEG microstates and EMG
Authors: Xin Rong , Zhao Shanguang , Yu Xianxian , Cheng Siman , Xie Jiale , Ling Gengqiang , Wei Xin , Wang Pu , Chen Steve SHYH-Ching
Published: December 2023

Stroke is a neurological disorder that profoundly affects patients' neural function and daily life. Although rehabilitation methods have made significant progress, there is still a need for innovative treatment strategies to improve the recovery outcomes of stroke patients. In this study, we employed electroencephalography (EEG) microstate analysis to investigate the influence of transcranial magnetic stimulation (TMS) on upper limb functional Rehabilitation in stroke patients with right hemiplegia, while also exploring the relationship between microstate patterns and improvements in muscle strength. The study involved 20 stroke patients with right-sided hemiparesis and 20 healthy right-handed control subjects recruited. All subjects underwent EEG and EMG data collection in a resting state. Before and after treatments，using the Upper Extremity Section of the Fugl-Meyer Assessment(FMA-UE) and the Action Research Arm Test (ARAT) to assess the upper extremity function of stroke patients. After one week of TMS treatment, data collection was repeated for patients. After TMS intervention, the FMA-UE scores and ARAT scores of stroke patients were significantly improved compared to the pre-treatment period (p < 0.05). Microstate B exhibited reduced time coverage and occurrence frequency in stroke patients (p < 0.05), but following TMS treatment, there was a significant increase in time coverage, approaching levels seen in the healthy control group (p < 0.05). Furthermore, we observed a significant reduction in the duration and time coverage of Microstate C and Microstate D following TMS treatment (p < 0.05). Encouragingly, the improvement in time coverage and occurrence frequency of Microstate B was positively correlated with the enhanced abilities of specific muscle groups, including upper limb muscles such as the flexor carpi ulnaris and extensor carpi ulnaris, highlighting the close relationship between Microstate B and improvements in motor control and muscle coordination. Changes in Microstate C were positively correlated with increased upper limb muscle strength, suggesting that Microstate C may play a crucial role in motor control and muscle coordination. This suggests that TMS may have a positive impact on neurorehabilitation in stroke patients, particularly concerning rehabilitation goals associated with Microstate B. In conclusion, our study underscores TMS can effectively promote upper limb motor function in stroke patients with right-sided hemiplegia and the critical link between microstate analysis and motor function recovery in stroke patients. Microstate B and Microstate C may serve as physiological indicators for assessing the progress of motor rehabilitation, providing valuable insights for developing more effective rehabilitation strategies and personalized rehabilitation plans.
A statistical analysis of the impact of gun ownership on mass shootings in the United States between 2013 and 2022
Authors: Kerns Lucy , Daraklis Madison , Pol Mehul , Johnson Lindsey , Salvatora Cianna
Published: December 2023

Mass shootings are becoming more frequent in the United States, posing a significant threat to public health and safety in the country. In the current study, we intended to analyze the impact of state-level prevalence of gun ownership on mass shootings - both the frequency and severity of these events. We applied the negative binomial generalized linear mixed model to investigate the association between gun ownership rate, as measured by a proxy (i.e, the proportion of suicides committed with firearms to total suicides), and population-adjusted rates of mass shooting incidents and fatalities at the state level from 2013 to 2022. Gun ownership was found to be significantly associated with the rate of mass shooting fatalities. Specifically, our model indicated that for every 1-SD increase - that is, for every 12.5% increase - in gun ownership, the rate of mass shooting fatalities increased by 34% (p-value < 0.001). However, no significant association was found between gun ownership and rate of mass shooting incidents. These findings suggest that restricting gun ownership (and therefore reducing availability to guns) may not decrease the number of mass shooting events, but it may save lives when these events occur.
Adaptation and validation of moral distress thermometer in Chinese nurses
Authors: Tian Xu , Gan Xiuni , Ren Yi , Li Feili , Herrera Maria F Jimenez , Liu Fangrong
Published: December 2023

Background:Moral distress seriously affects professional nurses, and a number of instruments have been developed to measure the level of moral distress. The moral distress thermometer (MDT) is one of the commonly used instruments that can rapidly measure real-time moral distress; however, it remains unclear whether it is still useful in the Chinese cultural context.Aim:This study aimed to adapt and validate the MDT among Chinese registered nurses.Research design:An online, cross-sectional, survey study of adapting and validating Chinese version of MDT.Participants and research context:A total of 182 registered nurses effectively finished this survey. The correlation between MDT score and the score of the moral distress scale-revised version (MDS-R) was used for evaluating convergent validity, and MDT scores of registered nurses who working in different departments and who made different actions to the final question of the MDS-R were compared by using one-way ANOVA to evaluate construct validity.Ethical considerations:The Ethics Committee of Chongqing Traditional Chinese Medicine Hospital approved this study (XYMS-20).Results:The Chinese version of MDT was described as relevant to measure moral distress. The mean MDT score and mean MDS-R score were 2.54 and 38.66, respectively, and the correlation between these two scores was significantly moderate (r= 0.41). Nurses working different departments reported different levels of moral distress, and those working in intensive care unit reported the highest level of moral distress than those working in other departments (p = 0.04). The MDT scores between nurses who presented different actions to their position were also significantly different, and those who had ever left and those who had considered leaving but did not leave reported significantly higher moral distress.Conclusion:The MDT is a reliable, valid, and easy-to-use instrument to rapidly measure the real-time moral distress of registered nurses in China.
Reproducible Neuronal Components found using Group Independent Component Analysis in Resting State Electroencephalographic Data
Authors: Ochoa-Gómez John Fredy , Mantilla-Ramos Yorguin-José , Isaza Verónica Henao , Tobón Carlos Andrés , Lopera Francisco , Aguillón David , Suárez Jazmín Ximena
Published: December 2023

Objective: Evaluate the reliability of neural components obtained from the application of the group ICA (gICA) methodology to resting-state EEG datasets acquired from multiple sites.
Methods: Five databases from three sites, covering a total of 292 healthy subjects, were analyzed. Each dataset was segmented into groups of 15 subjects, for a total of 19 groups. Data were pre-processed using an automatic pipeline leveraging robust average referencing, wavelet-ICA and automatic rejection of epochs. On each group, stable gICA decompositions were calculated using the ICASSO methodology through a range of orders of decompositions. Each order was characterized by reliability and neuralness metrics, which were evaluated to select a single order of decomposition. Finally, using the decompositions of the selected order, a clustering analysis was performed to find the common components across the 19 groups. Each cluster was characterized by the mean scalp map, its dipole generator with its localization in Talairach coordinates, the spectral behavior of the associated time-series of the components, the assigned ICLabel class and metrics that reflected their reproducibility.
Results: Lower order of decompositions benefits the gICA methodology. At this, using an order of ten, the number of reproducible components with high neuronal information tends to be around nine. Of these, the bilateral motor, frontal medial, and occipital neuronal components were the most reproducible across the different datasets, appearing in more than 89% of the 19 groups evaluated.
Conclusion: We developed a workflow that allows finding reproducible spatial filters between different data sets. This contributes to the improvement of the spatial resolution of the EEG as a brain mapping technique.
DNA Methylation is associated with oxidative stress and genomic deregulation in diabetes mellitus
Authors: Sen Subhrojit
Published: December 2023

Background:
Retrotransposons may undergo aberrant methylation leading to genomic deregulation in diabetes mellitus. The present study evaluated the methylation of retrotransposons namely Alu, B1, and LINE-1 elements in glucose-induced endothelial cells (ECs) and T1DM. The correlation between methylation of these retrotransposons and oxidative stress was investigated. Additionally, methylation of FN1, VEGFa, and EDN1 genes was analyzed.
Methods:
Hot start PCR of the bisulfite converted DNA isolated from the ECs and kidneys for the methylation of retrotransposons was analyzed. Quantification of methylated DNA in ECs was performed by ELISA. The methylation of the FN1, VEGFa, and EDN1 genes was examined. Oxidative stress was evaluated by measuring the superoxide anion, mitochondrial reactive oxygen species (ROS), 8-Hydroxyguanosine (8-OHdG), and NF-kappaB p(65).
Results:
Hypermethylation of Alu and LINE-1 elements occurred in the high glucose- induced ECs. B1 hypermethylation was observed in the kidneys of T1DM mice. Hyperglycemia resulted in LINE-1 hypermethylation in the kidneys of T1DM mice. Hypermethylation of the FN1, VEGFa and EDN1 genes occurred in the high glucose-induced ECs and diabetic kidneys. Hypermethylation of the retrotransposons, oxidative stress and NF-kappaB p(65) were inhibited by 5-Aza-Dc and ginseng treatment.
Conclusion:
This study illustrated that retrotransposon hypermethylation and oxidative stress were evident in the glucose-induced ECs and T1DM along with hypermethylation of the FN1, VEGFa and EDN1 genes. The study also demonstrated the association between hypermethylation of these retrotransposons and oxidative stress in diabetes.
Industry Concentration, Firm Size and Entry-Timing in Merger Waves
Authors:   Department of Banking and Finance, New Huadu Business School, Minjiang University, 200 Xiuangong Road, University Town, Fuzhou, Fujian, China, Lin Lin , Pun Ngou Teng ,   New Huadu Business School, Minjiang University, 200 Xiuangong Road, University Town, Fuzhou, Fujian, China, He Zhongda ,   New Huadu Business School, Minjiang University, 200 Xiuangong Road, University Town, Fuzhou, Fujian, China
Published: December 2023

As early mover advantage and late mover advantage have been discussed for decades, the conditions for the best use of them are yet unclear. Using the U.S. merger data during 2000–2019, this study examines the entry-timing and the post-merger performance of 1,376 bidders in the merger waves recognised. We find that early movers have advantages with higher post-merger performance in a merger wave, while the effect of late mover advantage is not significant. Moreover, early mover advantage can only be implemented in competitive industries. Our analysis further provides the entry-timing strategies for large firms and small/mid enterprises, respectively. Our results indicate that late mover advantage can only be adopted in large companies, while small/mid firms should be followers, not early or late movers, in high concentration industries. Overall, our study sheds new light on the entry-timing in a merger wave with the consideration of different market concentration environment and different firm size.
The Next-Generation Ecosystem Experiment Arctic Rainfall Simulator: a tool to understand the effects of changing rainfall patterns in the Arctic
Authors: Renner Caleb , Conroy Nathan , Thaler Evan , Collins Adam , Thomas Lauren , Dillard Shannon , Rowland Joel , Bennett Katrina
Published: December 2023

Rainfall frequency and intensity are expected to increase in the Arctic, with potential detrimental impacts on permafrost, leading to enhanced thawing and carbon release to the atmosphere. However, there have been very few studies on the effect of discrete rain events on permafrost in the Arctic and sub-Arctic. Conducting controlled rainfall experiments within permafrost landscapes can provide an improved understanding of the effect of changing intensity, duration, and timing of rain events on permafrost tundra ecosystems. Here, we describe the design and implementation of the Next-Generation Ecosystem Experiment Arctic Rainfall Simulator (NARS), a variable intensity (4–82 mm/h) rainfall simulator that can be used to study the effects of rainfall on permafrost stability. The NARS design includes a 3D-printed 4 cm H-flume and uses an eTape resistivity sensor that was calibrated (R2 = 0.9–0.96) to measure discharge from the system. NARS is designed to be lightweight, simple to construct, and can be easily deployed in remote locations. As a field validation of updated rainfall simulator design and modernized controls, NARS was tested on the Seward Peninsula, AK. Because of its portability, versatility in deployment, dimensions, and rainfall intensity, NARS represents a methodological innovation for researching the impacts of rainfall on permafrost environments.
Water environment response of urban water networks in the Pearl River Delta (China) under the influence of typhoon rain events
Authors: Shen Weiping , Jin Yuhao , Cong Peitong , Li Gengying
Published: December 2023

Identifying water quality parameter concentrations and their drivers is important for the prevention and control of water environment pollution. In this study, we constructed an inverse model of water quality parameters based on measured water quality parameters and remote sensing spectral data for this study area using artificial neural networks. We investigated the water environment response of the urban water network in the Pearl River Delta under the influence of typhoon rain events and explored their spatial heterogeneity using a multiscale geographically weighted regression model. The results indicate that in regions with a high level of urbanization, the dissolved oxygen (DO) concentration in river water is lower, and the ammonia nitrogen (NH3-N) concentration is higher. Under the influence of typhoon rain events of varying intensities, the response of water quality parameters in the urban water network of Zhongshan City varies. The intensity of rainfall determines the impact of typhoon rain events on water quality parameter concentrations. Our results are expected to improve the understanding of water quality trends under the influence of typhoon rain events and help policymakers and planners better develop water environment control strategies during typhoon transit.
Reducing particle accumulation in sewers for mitigation of combined sewer overflow impacts on urban rivers: a critical review of particles in sewer sediments
Authors: Wu Jun , Ma Yan , Song Shanshan
Published: December 2023

Sewer sediments contain various hazardous compounds, leading to significant pollution risks when combined sewer overflows (CSOs) occur without appropriate controls. This paper presents a comprehensive review of the issues associated with particles in sewers, specifically focusing on the non-negligible contribution of particulate matter to CSOs, which leads to pollution in urban rivers. Therefore, the sources of particulate matter in sewers, their contributions to the overflow particles, and the specific areas of concern when it comes to managing particulate matter during particle transportation are outlined. Overall, carefully considering the goal of avoiding sedimentation during the drainage system design is the most effective prevention and control method for pipeline sediment, where minimum velocity and minimum shear stress are the core parameters. The establishment of a flexible and adaptive particle simulation method in drainage pipelines requires reliable simulation of particle sedimentation and erosion, the development of sediment prevention facilities with strong adaptability, and a comprehensive evaluation of economic and environmental benefits. With the ongoing enhancement of urbanization in developing countries, such studies will have more practical significance.
The Usage of Industry 4.0 Enabling Technologies in the Education
Authors: Malyzhenkov Pavel Valer'evich
Published: December 2023

This paper analyzes the possibilities of applying technological trends of the Industry 4.0 concept in education within the framework of achieving Sustainable Development Goals. The task addressed in this work involves identifying the specifics and potential opportunities of digital technologies in the era of Industry 4.0 (both individually and through their integration) that are made available to education in the context of its digital transformation and transform it in the new concept «Education 4.0». The results show that not all digital technologies are equally applicable in the educational sphere.
Technologies in the classroom and their relationship with teaching practice
Authors: Dos Santos Allessandra Elisabeth , Boa Sorte Paulo
Published: December 2023

This article aims at analyzing the representations of four English language teachers regarding uses of technologies in order to understand the relationship of these representations and the practice of the teachers. We understand uses of technologies intertwined with experiences shared by members of a community which, in this case, we identify as language teachers, based on Social Representation Theory (Moscovici, 2010). This field research is a qualitative study. Data were collected through questionnaires, class observation and interviews, and analyzed according to Teacher-Research by Freeman (1998) and the coding process by Auerbach and Silverstein (2003). The analysis revealed two representations originated from six themes. In this article, we address the representation of technologies as essential pedagogical resources in English classes, based on the themes: analog technologies as an essential pedagogical resource in English classes and digital technologies as an essential pedagogical resource in English classes.
Interprofessional practice and health care: a study in a Multi-professional Health residence
Authors: Silva Ana Beatriz Ferreira Barros da , Cardoso Talita Miranda Pitanga Barbosa , Leal Juliana Alves Leite , Araújo Mariana de Oliveira , Merces Magno Conceição das , Souza Marcio Costa de
Published: December 2023

Objetivo: analisar as práticas de cuidado na perspectiva interprofissional em uma residência multiprofissional em saúde. Método: Pesquisa qualitativa de natureza exploratória realizada em um Programa de Residência Multiprofissional em Saúde de uma universidade pública do estado da Bahia, Brasil. As ferramentas para a produção dos dados foram a entrevista semi estruturada e o diário de campo. A amostra foi definida por meio da saturação dos dados composta por 13 residentes entrevistados distribuídos em cinco campos de atuação da residência (Saúde da Família, Saúde Mental, Nutrição Clínica, Oncologia e Terapia Intensiva). Os dados das entrevistas foram interpretados por meio de análise de conteúdo, onde emergiu uma categoria: Prática Interprofissional na Residência: experiências ou políticas? Resultados: As atividades práticas de caráter interprofissional ocorrem de acordo com  o ponto de atenção para o cuidado, e essas vivências dependem dos trabalhadores desses locais, o que demonstra que não há uma política institucional. Na atenção básica, permite ao residente ter uma visão ampliada da saúde e, assim, sobressai à subjetividade, o que permite associar a formação ainda pautada no modelo biomédico. Considerações finais: As práticas interprofissionais acontecem principalmente com residentes de saúde da família e que o processo de formação do residente possibilita o desenvolvimento de uma perspectiva subjetiva sobre o cuidado, diferente dos demais módulos.
Palavras-Chave: Formação Profissional; Cuidado Centrado no Paciente; Educação Interprofissional.
O manejo peri-hospitalar de pacientes com Doença de Parkinson e pneumonia broncoaspirativa: relato de experiência
Authors: Faria Cristiane de Almeida , Almeida Yasmin Saba de , Tavares Felipe Guimarães
Published: December 2023

Considerada a segunda doença neurodegenerativa mais prevalente na população idosa, a Doença de Parkinson é uma patologia crônica, de causa multifatorial, que dentre outros sintomas, provoca desordens do movimento. Advindas secundariamente, as alterações respiratórias podem ocasionar as pneumonias broncoaspirativas que levam a internações hospitalares recorrentes e podem compreender uma das principais causas de morte na Doença de Parkinson. Este estudo tem como objetivo descrever uma experiência exitosa, discutindo os principais aspectos relacionados ao manejo peri-hospitalar de pacientes com DP em tratamento de pneumonia broncoaspirativa, a partir da perspectiva de um profissional de fisioterapia. Trata-se de um relato de experiência sobre a atuação de um profissional de fisioterapia em uma Unidade de Internação na especialidade de Clínica Médica de um hospital de referência da Região Norte do Brasil, com pacientes com Doença de Parkinson em tratamento de pneumonia broncoaspirativa. O cuidado do paciente com Doença de Parkinson por seus familiares/cuidadores é envolto de desafios. O medo e a insegurança se tornam presentes no dia-a-dia quando se trata de um paciente acamado em domicílio com necessidade de cuidados que, muitas vezes, não é de experiência diária de um parente cuidador. Nesse contexto, o fisioterapeuta, juntamente dos demais membros da equipe multiprofissional, possui um papel fundamental no que tange a assistência peri-hospitalar do paciente parkinsoniano, de forma a garantir o  treinamento adequado dos familiares/cuidadores para atuarem na aspiração de vias aéreas do paciente em uso de traqueostomia, para que seja possivel dar continidade nos cuidados domiciliares e reduzir a taxa de reinternação.
Palavras-Chave: Doença de Parkinson; Pneumonia Aspirativa; Manuseio das Vias Aéreas; Assistência Integral à Saúde.
Determinantes Sociais da Saúde relacionados ao Vírus da Imunodeficiência Humana em adultos: protocolo de revisão de escopo
Authors: Montanha Rafaela Marioto , Bolorino Natacha , Gonçalves Laís Cristina , Ferreira Natalia Marciano de Araujo , Souza Ana Beatriz Floriano de , Pieri Flávia Meneguetti
Published: December 2023

Este protocolo de revisão tem como objetivo descrever a sistematização do desenvolvimento de uma revisão de escopo, visando mapear e sintetizar as evidências científicas de estudos ecológicos que abordam os Determinantes Sociais da Saúde relacionados a infecção pelo Vírus da Imunodeficiência Humana (HIV) em indivíduos adultos. Sua elaboração tem base nas recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses - Extension for Scoping Reviews, atendendo às orientações do Instituto Joanna Briggs. Espera-se que as evidências encontradas na literatura nacional e internacional possam contribuir para melhor compreensão dos Determinando Sociais da Saúde e sua relação com a infecção e manutenção do HIV em diferentes áreas geográficas.
Repercussões da violência doméstica contra mulher para crianças sob ótica de agentes comunitários de saúde
Authors: Couto Maria Vitória Oliveira , Morais Roberta Laíse Gomes Leite de , Luz Rosália Teixeira , Rodrigues Vanda Palmarella , Vilela Alba Benemérita Alves , Machado Juliana Costa
Published: December 2023

Introdução: Comportamentos violentos em famílias com a presença de crianças traz repercussões adversas na sua saúde e no seu desenvolvimento. Objetivou-se averiguar as concepções dos agentes comunitários de saúde sobre as repercussões da violência doméstica contra a mulher para as crianças que convivem nesse contexto. Materiais e Métodos: Trata-se de uma pesquisa de cunho descritivo e exploratório de natureza qualitativa, cujos dados foram coletados de maio a agosto de 2019, em 11 Unidades de Saúde da Família, de um município do interior da Bahia, com 30 agentes comunitários de saúde e analisados a partir da técnica de análise de conteúdo modalidade temática. Resultados e Discussão: As repercussões da violência doméstica contra as mulheres interferem nas áreas físicas, cognitivas, emocionais e sociais de desenvolvimento infantil, afetando diretamente suas relações futuras. O uso de álcool e a dominação também se apresentaram como fatores precipitadores da violência entre mulheres e crianças. Constatou-se a negligência no cuidado à criança pela mãe, em decorrência da violência doméstica contra a mulher. Considerações finais: Os agentes comunitários de saúde podem corroborar para a ampliação de conhecimentos sobre as repercussões da violência na vida de mulheres e crianças. De modo que, sua atuação também possibilita o aperfeiçoamento de intervenções, por meio da promoção e prevenção à saúde de mulheres e crianças expostas à violência doméstica. 
Palavras-chaves: Violência contra a Mulher; Exposição à Violência; Criança; Saúde da Família; Agentes Comunitários de Saúde.
Incidência e prognóstico das neoplasias de pâncreas: uma revisão integrativa da literatura
Authors: Rodrigues de Oliveira Silva Brendo , Lima de Moraes Ludmila , Conceição de Siqueira Emilio
Published: December 2023

As neoplasias são patologias genéticas e/ou fenotípicas que muitas vezes levam à morte, sendo a neoplasia de pâncreas umas das mais insidiosas e de rápida evolução.O objetivo geral do presente artigo foi estudar a incidência e prognóstico das neoplasias de pâncreas, considerando suas manifestações clínicas, tratamentos de acordo estadiamento e respostas terapêuticas.Para tal, foi realizada uma pesquisa bibliográfica em bases de dados virtuais, na qual foram selecionados trabalhos que fundamentam o objetivo proposto.O estudo observou que ainda não há métodos eficazes para detecção precoce da patologia, levando a prognósticos reservados, uma vez que a localização retroperitonial da glândula torna a doença neoplásica assintomática até uma fase avançada e que não há marcadores diagnósticos específicos.

Palavras-chave: Neoplasias Pancreáticas; Incidência; Prognóstico.
Influência de fatores nutricionais na enxaqueca: uma revisão integrativa
Authors: Medeiros Pacheco Ribeiro Fernanda , Barcellos Bernardes de Souza Isabela , Da Silva Soares Telles Barbara , Calmon Nogueira da Gama Pereira Ana Beatriz
Published: December 2023

A enxaqueca é uma doença neurológica crônica, cuja dor é latejante, unilateral, acompanhada de fotofobia, fonofobia e náuseas/vômitos durante a crise. Sua fisiopatologia não está completamente elucidada, porém sabe-se que existe inflamação neurogênica. Muitos medicamentos são utilizados para crise e profilaxia, porém apresentam efeitos colaterais e estudos apontam benefício da terapia não medicamentosa baseada em aporte nutricional, como alternativa para esses pacientes. O presente estudo tem por objetivo analisar a influência de fatores nutricionais na enxaqueca. Foi realizada uma pesquisa nas bases de dados PubMed e BVS com os descritores “migraine” e “nutrition”, utilizando o operador boleano “and” no mês de junho de 2023. Foram incluidos artigos publicados nos últimos 5 anos, de texto completo gratuito e excluídos artigos de revisão sistemática e que não se enquadravam no tema. Após o uso dos critérios e leitura dos trabalhos, foram selecionados 18 artigos. As crises de enxaqueca podem ser desencadeadas por gatilhos relacionados a hábitos alimentares, a obesidade é um importante fator de risco e o aumento de nutrientes com propriedades antiinflamatórias trazem benefícios. Foram avaliados nos artigos a dieta cetogênica, rica em alimentos com gorduras insaturadas, curcumina, ácidos graxos ômega-3 e ômega-6, ácido alfa-lipóico, isoflavonas, vitamina D, Vitamina B3, cálcio, magnésio, zinco e ferro. Conclui-se que a mudança nos hábitos alimentares gera melhora na gravidade da enxaqueca, uma vez que, a dieta cetogênica e a ação anti-inflamatória da suplementação de ômega-3, principalmente associada a curcumina, demonstraram interferência positiva na frequência, intensidade e duração das dores de cabeça.
The Interplay Between Gut Microbiota and Central Nervous System
Authors: Gervasi Teresa , Mandalari Giuseppina
Published: December 2023

This review highlights the relationships between gastrointestinal microorganisms and the brain. The
gut microbiota communicates with the central nervous system through nervous, endocrine, and immune signalling
mechanisms. Our brain can modulate the gut microbiota structure and function through the autonomic
nervous system, and possibly through neurotransmitters which directly act on bacterial gene expression. In this
context, oxidative stress is one the main factors involved in the dysregulation of the gut-brain axis and consequently
in neurodegenerative disorders. Several factors influence the susceptibility to oxidative stress by altering
the antioxidant status or free oxygen radical generation. Amongst these, of interest is alcohol, a commonly
used substance which can negatively influence the central nervous system and gut microbiota, with a key role
in the development of neurodegenerative disorder. The role of “psychobiotics” as a novel contrast strategy for
preventing and treating disorders caused due to alcohol use and abuse has been investigated.
Epigenetic Diversity Underlying Seasonal and Annual Variations in
Brown Planthopper (BPH) Populations as Revealed by Methylationsensitive
Restriction Assay
Authors: Gupta Ayushi , Nair Suresh
Published: December 2023

Background::

The brown planthopper (BPH) is a monophagous sap-sucking insect pest
of rice that is responsible for massive yield loss. BPH populations, even when genetically homogenous,
can display a vast range of phenotypes, and the development of effective pest-management
strategies requires a good understanding of what generates this phenotypic variation. One potential
source could be epigenetic differences.

Methods::

With this premise, we explored epigenetic diversity, structure and differentiation in
field populations of BPH collected across the rice-growing seasons over a period of two consecutive
years. Using a modified methylation-sensitive restriction assay (MSRA) and CpG island amplification-
representational difference analysis, site-specific cytosine methylation of five stress-responsive
genes (CYP6AY1, CYP6ER1, Carboxylesterase, Endoglucanase, Tf2-transposon) was estimated,
for identifying methylation-based epiallelic markers and epigenetic variation across BPH
populations.

Results::

Screening field-collected BPH populations revealed the presence of previously unreported
epigenetic polymorphisms and provided a platform for future studies aimed at investigating
their significance for BPH. Furthermore, these findings can form the basis for understanding the
contribution(s) of DNA methylation in providing phenotypic plasticity to BPH.

Conclusion::

Screening field-collected BPH populations revealed the presence of previously unreported
epigenetic polymorphisms and provided a platform for future studies aimed at investigating
their significance for BPH. Furthermore, these findings can form the basis for understanding the
contribution(s) of DNA methylation in providing phenotypic plasticity to BPH.
Fluorometric Sensing of Metal Ions by Carbon Nano Dots - A Review
Authors: Yadav Rajnee , Lahariya Vikas Lahariya
Published: December 2023

abstract:

Contamination from heavy metal ions is a rising problem. It has direct and
indirect impacts on human health, the environment, and aquatic life. Thus, detecting
trace amounts of these elements presents significant challenges. It is important to develop
effective, affordable, accurate, fast sensing monitoring systems. A new field of
sensing techniques has emerged with the discovery of bio-compatible fluorescent carbon
nanodots. Although the study of heavy metal ion detection using carbon nanodots
and fluorometric sensing techniques is relatively new and developing, it holds great
potential for aiding scientists in the development of environmentally friendly sensing
systems. This article focuses on the utilization of carbon nanodots in fluorescencebased
detection of metal ions in various media. The ability to emit fluorescence
across the entire visible spectrum under UV and visible light excitation offers fluorescent
quenching or fluorescent enhancement phenomena in the presence of trace
amount of metal ions. The present work discusses different fluorometric sensing phenomena,
its mechanism and applications of carbon dots on it. It covers the recent progress
in carbon-nano dots for bio-based synthesis, physical properties, and application
in heavy metal sensing.
Navigating the Solution to Drug Formulation Problems at Research and
Development Stages by Amorphous Solid Dispersion Technology
Authors: Tripathi Devika , B.H Manjunatha Prabhu , Sahoo Jagannath , Kumari Jyoti
Published: December 2023

Amorphous Solid Dispersions (ASDs) have indeed revolutionized the pharmaceutical industry,
particularly in drug solubility enhancement. The amorphous state of a drug, which is a highenergy
metastable state, can lead to an increase in the apparent solubility of the drug. This is due to
the absence of a long-range molecular order, which results in higher molecular mobility and free
volume, and consequently, higher solubility. The success of ASD preparation depends on the selection
of appropriate excipients, particularly polymers that play a crucial role in drug solubility and
physical stability. However, ASDs face challenges due to their thermodynamic instability or tendency
to recrystallize. Measuring the crystallinity of the active pharmaceutical ingredient (API) and
drug solubility is a complex process that requires a thorough understanding of drug-polymer miscibility
and molecular interactions. Therefore, it is important to monitor drug solids closely during
preparation, storage, and application. Techniques such as solid-state nuclear magnetic resonance
(ssNMR), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), Raman
spectroscopy, and dielectric spectroscopy have been successful in understanding the mechanism of
drug crystallization. In addition, the continuous downstream processing of drug-loaded ASDs has
introduced new automated methods for consistent ASD production. Advanced techniques such as
hot melt extrusion, KinetiSol, electro spraying, and electrospinning have gained popularity. This review
provides a comprehensive overview of Amorphous Solid Dispersions (ASDs) for oral drug delivery.
It highlights the critical challenges faced during formulation, the impact of manufacturing
variables, theoretical aspects of drug-polymer interaction, and factors related to drug-polymer miscibility.
ASDs have been recognized as a promising strategy to improve the oral bioavailability of
poorly water-soluble drugs. However, the successful development of an ASD-based drug product is
not straightforward due to the complexity of the ASD systems. The formulation and process parameters
can significantly influence the performance of the final product. Understanding the interactions
between the drug and polymer in ASDs is crucial for predicting their stability and performance.
Analisis Agenda-setting Policy dalam Proses Penyelenggaraan Formula E di DKI Jakarta
Authors: Alfathon Rivaldi Pradana , Fauzi Said Mochammad , Ilman Hakim Andy
Published: December 2023

This research aims to analyze studies related to the dynamics of agenda-setting policy in the process of implementing Formula E in DKI Jakarta. This research uses agenda-setting policy theory developed by John W. Kingdon. This research analyzes the interactions carried out by the actors involved in the process of organizing Formula E in DKI Jakarta. The research method used in this research is a qualitative research method. In order to obtain primary research data, researchers interviewed pro and con parties in this research, one of which was the DKI Jakarta Provincial Government and several factions in the Regional People's Representative Council (DPRD) of DKI Jakarta Province. Researchers also use secondary data originating from various mass media and other literature sources. The results of this research show that there is a polemic of pros and cons in the process of holding Formula E in DKI Jakarta. This polemic exists because there are interests from each party. Through political streams, researchers found the formation of coalitions to fight for the respective interests held by various parties. This aims to include these interests so that they can be put at the top of a policy agenda. Political stream is the most dominant aspect in the dynamics of agenda-setting for the Formula E implementation process in DKI Jakarta.
Politik Kewargaan: Melacak Perjuangan Kelompok Penghayat Kerohanian Sapta Darma Kota Malang dalam Mendapatkan Hak sebagai Warga Negara
Authors: Qisthi Rosyidah Ainun
Published: December 2023

This study aims to explain how the struggle of the Sapta Darma kerokhanian group in Malang City in obtaining their rights as citizens. This research is important to do as a benchmark of the obligations that should be given by the government in the form of rights as citizens to marginalized people, in this case are followers of the Sapta Darma faith in Malang City. By borrowing the framework of citizenship political theory from Kristian Stokke which divides into four dimensions of citizenship, namely citizenship as a legal status, citizenship as a right, citizenship as membership, and citizenship as participation. This research uses descriptive qualitative methods with data collection through literature studies, document studies, interviews, and observations. The results of this study show that the Sapta Darma faith group has made various efforts as a form of struggle to obtain various rights, namely membership rights, legal status as an organization or community, civil rights, social rights, political rights, and participation rights. The findings of this study show that the Sapta Darma faith group in Malang City has proven to be very proactive and initiatives towards government institutions in various fields such as administrative, educational and social spheres.
Advancing social impact through Islamic social finance: A comprehensive bibliometric analysis
Authors:   Department of Sharia Economic Law, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia, Apriantoro Muhamad Subhi , Muthoifin Muthoifin ,   Department of Sharia Economic Law, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia, Athief Fauzul Hanif Noor ,   Department of Sharia Economic Law, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia
Published: December 2023

Islamic social finance (ISF) has recently received much attention for its potential to address social problems such as poverty, hunger, and unequal wealth distribution. This study aims to map ISF research through a bibliometric analysis of 502 publications in the Scopus database from 1979 to 2022. Using state-of-the-art tools such as VOSviewer and R Studio, we uncover publication trends, co-authorship networks, and bibliographic integration in the field. Our results show a promising annual growth rate of 9.26% in ISF publications, with Malaysia and Hasan M. K. leading and Malaysia International Islamic University as the affiliate with the highest publication contribution. This study provides valuable recommendations for future research to enhance our understanding of ISF and unlock its potential social impact. However, we must first acknowledge the limitations of using Scopus data exclusively. Through this study, we hope to inspire further exploration of the power of ISF to create positive change in our world.
Order Creates Value: Personality, Attitudinal and Behavioral Factors of Financial Vulnerability
Authors: Németh Erzsébet , Deák-Zsótér Boglárka , Géza Kálmán Botond
Published: December 2023

In our research, we aim to become acquainted with the attitudes and financial behaviours of financially fragile social groups. Based on an online questionnaire survey (N=22933 adult), we formed groups by cluster analysis and compared them to each other. We examined the groups with multivariable statistical methods, underscoring the characteristics relating to financial vulnerability. Beside we developed the metric for financial fragility. The results draw attention that financial fragility has multiple, complex, interrelated reasons. In terms of financial personality, attitude, and behaviour, they reached the highest average point in case of distinctly adverse claims, while the lowest at beneficial claims. Our results demonstrate that even if the financially vulnerable cluster accounts for 9%, the group of 'money pits' and the 'passive' show several such attitudes and behavioural patterns that could lead to financial fragility in the future. The cumulative ratio of these groups amounts to 32%. Financially vulnerable people do not take good care of either their finances or their household, they can't plan or prolong their wishes, and they judge their situation incurable, which is coupled with anxiety.