bluuebunny/crossref_metadata_2025 huggingface dataset:
Flow Characteristics and Heat Transfer Enhancement of Sinusoidal Corrugated Channels with Different Configurations
Authors: ÖZBOLAT Veli , ŞAHİN Beşir
Published: March 2022

This study investigated flow characteristics and heat transfer enhancement in various sinusoidal corrugated channels. The channel height and the phase shift effects on the flow structures and thermal performances were examined numerically for Reynolds numbers in the range of 2500≤Re≤7500. The geometrical configurations of this study cover three different channel heights (Hmin/Hmax=0.36, 0.54, 0.72) and three phase shift angles (φ=0°, 90°, 180°). Velocity distribution, turbulence intensity, local and averaged Nusselt numbers, and friction factor were calculated for various configurations. Finally, thermal performance factors (TPF) were also calculated to determine the optimum channel configuration and

operating condition.
Study on immobilization of nitrogen and phosphorus in sediments using modified fly ash composite material
Authors: Zou Jiale , Sun Rongqiang , Zhu Zhaoliang , Zhou Hao , Ji Xinyu
Published: March 2022

In this paper, a new type of particle-modified fly ash composite material was prepared using fly ash as the main raw material, which could immobilize nitrogen and phosphorus pollutants in sediment and control its release into water. Preliminary modification of fly ash was achieved by soaking in NaOH and calcining at high temperature of CaO. The modified fly ash was mixed with four auxiliary materials, namely cement, slag, water glass and quartz sand, and was formed after 14 days of curing. X-ray diffraction (XRD) and scanning electron microscope-energy dispersive spectrometer (SEM-EDS) were used to examine the material microstructure, element composition, crystal mineral changes, and also to further examine the physical indicators and mechanical properties of the material. In the end, we chose to use modified fly ash composite 10% cement to make granular modified fly ash composite materials. Taking the actual polluted river sediment as the research object, a 22-day coverage effect experiment was carried out, and it was finally found that the 2 cm-thick modified fly ash composite material cover layer inhibited the ammonia nitrogen (NH4+-N)、total nitrogen (TN) and total phosphorus (TP) of the sediments at 90.91%, 75.06% and 90.63%, respectively. This confirms that it is a material with good performance and practical application value.
New Contours of Transformation of Public Power in the Russian Federation
Authors: Gligich-Zolotareva M. V. , Lykjanova N. I.
Published: March 2022

Constitutional innovations required revision of a large part of legislation, first of all, the “basic” federal laws of October 6, 1999 No. 184-FZ “On general principles of organization of Legislative (Representative) and Executive state authorities of the Subjects of the Russian Federation” and of October 6, 2003 No. 131-FZ “On general principles of organization of local Self-Government in the Russian Federation”. Currently the process of transformation of public power in Russia has started. The recently adopted Federal Law No. 414-FZ of December 21, 2021 “On the General Principles of the Organization of Public Power in the Subjects of the Russian Federation” is being implemented in the constituent entities of the Russian Federation. At the same time, the reform of public authorities at the local level is being developed. Consideration of the project of Federal Law No. 40361-8 “On the general principles of the organization of local self-government in the unified system of public authority” has been postponed. Because of the difficult political and economic situation, the creation of a new organizational management system for regions and municipalities will ensure the development of territories, promptly correcting the process using modern information technologies.
Methodological Approaches to the Assessment of Scientific Activity of Russian Regions
Authors: Kuznetsova O. V.
Published: March 2022

Currently, one of the tasks of the state socio-economic policy in Russia is to increase the role of regional authorities in the scientific and technological development of regions. One of the tools for solving this problem should be the development of a national rating of scientific and technological development of the subjects of the Russian Federation. The Russian Academy of Sciences initiated the development of the index of scientific activity of the regions. This article suggests methodological approaches to the development of such an index, the main innovations of which should be an emphasis on the scientific development of regions (as opposed to the indices of innovative development), a separate assessment of the current level of development of science and its potential, an assessment of the scientific policy of regional authorities, an expanded range of indicators for training personnel for science, and starting from additional education of children. The possibilities of improving the indicators traditionally used to assess the scientific and technological development of regions are discussed, including in terms of more correct accounting of the activities of universities. It is proposed to develop a regional standard for scientific policy.
Foreign Investments in the National and Regional Economy of Russia
Authors: Oveshnikova L. V. , Sibirskaya E. V.
Published: March 2022

The problem of attracting foreign investment in the domestic economy has existed for many years and continues to retain its significance to this day. Despite the active work of foreign investors in the Russian economy, it loses competition to many states in terms of the amount of foreign capital attracted. This problem is relevant at the present time, due to the aggravated foreign economic disagreements and contradictions, since investments are extremely important for financing economic growth and ensuring economic security and protection. The need to study the problems of attracting foreign investment is also determined by the fact that Russia, having a huge investment potential for foreign investors, still has some risks that are a barrier to attract capital in the form of foreign investment in the Russian economy. The study focuses on the structural and dynamic component of attracting foreign investment in the national and regional economy of Russia, contributes to the disclosure of the reasons that affect the decline in global investment in the Russian economy and allows you to identify prospects for attracting foreign investment and investment activities in the Russian Federation with the participation of foreign investors.
Ivabradine in the Management of COVID-19-related Cardiovascular Complications:
A Perspective
Authors: Baka Tomas , Repova Kristina , Luptak Ivan , Simko Fedor
Published: March 2022

Besides acute respiratory distress syndrome, acute cardiac injury is a major complication in severe
coronavirus disease 2019 (COVID-19) and is associated with a poor clinical outcome. Acute cardiac injury with
COVID-19 can be of various etiologies, including myocardial ischemia or infarction and myocarditis, and may
compromise cardiac function, resulting in acute heart failure or cardiogenic shock. Systemic inflammatory
response increases heart rate (HR), which disrupts the myocardial oxygen supply/demand balance and worsens
cardiac energy efficiency, thus further deteriorating the cardiac performance of the injured myocardium. In fact,
the combination of elevated resting HR and markers of inflammation synergistically predicts adverse cardiovascular
prognosis. Thus, targeted HR reduction may potentially be of benefit in cardiovascular pathologies
associated with COVID-19. Ivabradine is a drug that selectively reduces HR via If current inhibition in the sinoatrial
node without a negative effect on inotropy. Besides selective HR reduction, ivabradine was found to exert
various beneficial pleiotropic effects, either HR-dependent or HR-independent, including anti-inflammatory,
anti-atherosclerotic, anti-oxidant and antiproliferative actions and the attenuation of endothelial dysfunction and
neurohumoral activation. Cardioprotection by ivabradine has already been indicated in cardiovascular pathologies
that are prevalent with COVID-19, including myocarditis, acute coronary syndrome, cardiogenic shock or
cardiac dysautonomia. Here, we suggest that ivabradine may be beneficial in the management of COVID-19-
related cardiovascular complications.
Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s
Disease: An Overview
Authors: Prasanna Chandu Anantha Lakshmi , Sharma Abha
Published: March 2022

Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disorder that may account for approximately 60-70% of cases of dementia worldwide. AD is characterized by im-paired behavioural and cognitive functions, including memory, language, conception, attentiveness, judgment, and reasoning problems. The two important hallmarks of AD are the appearance of plaques and tangles of amyloid-beta (Aβ) and tau proteins, respectively, in the brain based on the etiology of the disease, including cholinergic impairment, metal dyshomeostasis, oxidative stress, and degrada-tion of neurotransmitters. Currently, the used medication only provides alleviation of symptoms but is not effective in curing the disease, which creates the need to develop new molecules to treat AD. Heterocyclic compounds have proven their ability to be developed as drugs for the treatment of vari-ous diseases. The five-membered heterocyclic compound triazole has received foremost fascination for the discovery of new drugs due to the possibility of structural variation. Moreover, it has proved its significance in various drug categories. This review mainly summarizes the recent advancements in the development of novel 1,2,3-triazole and 1,2,4-triazole-based molecules in the drug discovery process for targeting various AD targets such as phosphodiesterase 1 (PDE1) inhibitors, apoptosis signal-regulating kinase 1 (ASK1) inhibitors, somatostatin receptor subtype-4 (SSTR4) agonist, sev-eral other druggable targets, molecular modelling studies, as well as various methodologies for the synthesis of triazoles containing molecules such as click reaction, Pellizzari reaction, and Einhorn-Brunner reaction.
Profile of Gut Microbiota of Adults with Diabetes Mellitus Type 1: A
Systematic Review
Authors: Moreira Larissa Almenara Abreu , da Paz Lima Larissa , de Oliveira Falcão Maíra Aparecida , Rosado Eliane Lopes
Published: March 2022

Background:

Type 1 diabetes mellitus (T1DM) is a chronic disease of clinical importance,
whose prevalence has increased in Brazil and worldwide. Among the possible factors involved
in the genesis and control of the disease, the intestinal microbiota (IM) deserves to be highlighted,
but studies that report differences between the IM of patients with T1DM and those who
are healthy are still contradictory and scarce.

Objective:

The objective of this paper was to evaluate the IM profile of T1DM and healthy patients,
in order to verify possible differences and to evaluate the possibility of the influence of IM
on glycemic control in T1DM.

Methods:

Of the 2716 articles found, nine were included in this review, and all of which were randomized,
observational, cross-sectional, cohort and case-control studies that characterized the
composition of IM in adults with T1DM and healthy adults.

Results:

Studies are very diverse, which makes it difficult to associate the IM profile with T1DM
etiology and control, however it was found that there was a prevalence of the phylum Firmicutes in
the IM of individuals with T1DM and that there was no significant difference in the relative abundance
of Bacteroidetes in both populations.

Conclusion:

It was also possible to identify an inverse relationship of the genus Bifidobacterium
and a positive relationship of the genera Bacteroidetes and Prevotella with the concentration
ofglycated hemoglobin. More studies are needed to contemplate the characterization of IM in
healthy and T1DM individuals.
Low-Cost Technologies that can be Integrated into Medical Education in
Emerging Areas
Authors: Țoța Paul , Vaida Mircea-Florin
Published: March 2022

Background:

The situation created by global emergencies, such as the current global pandemic
[1], has led in many parts of the world to the cessation of clinical practice in hospitals for medical
and nursing students, although in medical education the contact with the patient and the practical
practice of various medical techniques and procedures by contact is necessary. However, in situations
of biological risk, it is natural to avoid any possibility of exposure for students.

Material and Methods:

The objective of this paper is to analyze the possibility of creating low cost,
modular telepresence robots, adapted for medical clinical practice and capable of allowing practicing
students to interact remotely with patients, communicate with them, monitor them, help them move,
and also to be able to measure parameters such as temperature using thermal vision, pulse measurement
or, the ability of the limbs to move. The robot consists of a mobile stretcher, with the possibility
of moving both with wheels and with the help of legs, which allows the patient to move without human
assistance in areas with obstacles. The method of achieving this goal refers to the realization of several
modular applications and each to solve specific tasks, and finally to be interconnected in a telepresence
robot that makes possible the remote interaction of practicing students with patients.

Results:

The research results emerge both from the prototypes made and from the simulations and the
results of measuring certain vital parameters sent by the telepresence robot via the internet to the medical
team.

Conclusion:

The idea of modular integration of several individual applications is feasible and offers
the advantage of easily adapting to patients with various ailments and medical needs.
Transition resistance influence of the upper structure track ballast on the rail-to-earth potential at AC railway sections
Authors: Krylov A. A. , Rebrov I. A. , Rudashevskaya A. V. , Rudashevskiy R. A. , Khar'kovskaya E. D.
Published: March 2022

Introduction. The purpose of the research is to evaluate transition resistance modifications of the upper structure track in passing from the ballast to the ballastless track. These modifications effect the rail-to-earth potential difference. Moreover, they refer to the reverse traction system, to the reverse traction current of railway automation devices and to the required level of electrical safety guarantee.

Materials and methods. The authors used both the analytical method of the rail-to-earth potential testing and the practical one based on experimental studies of the rail track transition resistance measurements. The authors carried out experiments on the Rozengartovka — Boitsovo — Bikin section of the Far Eastern Railway. This section includes the heavy freight traffic with the increased electric resistance of the track ballast by the upper structure redevelopment.

Results. The research defines the main criteria of the rail-to-earth potential considering the 2×25 and 25 kV reverse traction of monophase AC systems with the 50 Hz frequency and depending on the experimental area location in terms of traction substations, on the climate and geological factors and on the freight traffic density.

Discussion and conclusion. The obtained results will improve the accuracy of the rail-to-earth potential difference considering not only indicated factors, but also the upper structure type, track features and a feed line scheme for contact wire.
Исследование особенностей эпитаксиального роста GaAs на подложках Si, модифицированных фокусированными ионными пучками
Authors: Балакирев C.B. , Ерёменко М.М. , Лахина Е.А. , Кириченко Д.В. , Шандыба Н.А. , Черненко Н.Е. , Агеев О.А. , Солодовник М.С.
Published: March 2022

In this paper, we present a study of the effect of the silicon substrate modification by focused ion beams on subsequent growth of GaAs layers by molecular beam epitaxy. We demonstrate that when samples exposed to the ion irradiation at various accelerating voltages and ion beam passes are annealed in the absence of the arsenic flux, an increase in the depth of the modified Si substrate areas occurs. At the same time, crystallization of gallium accumulations during annealing in the arsenic flux leads to the filling of holes formed during the ion bombardment. We reveal that the growth of GaAs on substrates with areas modified at an accelerating voltage of 30 kV and subjected to subsequent annealing in the arsenic flux at a temperature of 600 °C is accompanied by the formation of nanowires, the density of which increases within areas with a large number of ion beam passes. The results of the conducted research can be used for the development of technological approaches to the formation of GaAs epitaxial layers on Si substrates.
Упругие постоянные и силовые константы межатомных связей соединений A-=SUP=-II-=/SUP=--=SUB=--=/SUB=-B_2-=SUP=-III-=/SUP=-C_4-=SUP=-VI-=/SUP=-
Authors: Мамедова И.А. , Джахангирли З.А. , Керимова Т.Г. , Сеидов Р.Г. , Абдуллаев Н.А.
Published: March 2022

С помощью теории функционала плотности (DFT) рассчитаны величины упругих постоянных cij тиогалатов CdGa2S4, CdGa2Se4, CdGa2Te4 и ZnGa2Sе4. Вычислены величины объемных модулей упругости B. Установлены закономерности в зависимостях величин частот оптических фононов от масс атомов в соединениях AIIB_2IIIC_4VI. Определены силовые константы межатомных связей в соединениях CdGa2Te4 и ZnGa2Sе4. Ключевые слова: упругие постоянные, силовые константы, фононы, рамановское рассеяние, тетрагональная сингония, приведенная масса, халькопириты.
Условия механической стабильности и упругие свойства кристаллических структур с разной симметрией
Authors: Гусев А.И. , Садовников С.И.
Published: March 2022

A critical analysis of the conditions of elastic stability of crystal structures of different symmetry as restrictions imposed on their elastic constants cij has been carried out. It is shown that the conditions of elastic stability of all crystals, except for cubic ones, are described by polynomials from the second to sixth powers of their elastic constants cij. Necessary and sufficient conditions for the elastic stability of crystals of different symmetry are presented explicitly.
Структура и свойства наночастиц Co-=SUB=-x-=/SUB=-Mn-=SUB=-1-x-=/SUB=-Fe-=SUB=-2-=/SUB=-O-=SUB=-4-=/SUB=- в зависимости от количества ионов Co (0≤ x≤ 1.0)
Authors: Камзин А.С. , Obaidat I.M. , Семенов В.Г. , Narayanaswamy V. , Al-Omari I.A. , Issa B. , Бурьяненко И.В.
Published: March 2022

Изучены свойства магнитных наночастиц (МНЧ) ферритов-шпинелей CoxMn1-xFe2O4 (при x=0.0, 0.2, 0.3, 0.4, 0.5, 0.6, 0.8, 1.0), синтезированых методом химического соосаждения. Исследования синтезированных МНЧ CoxMn1-xFe2O4 проведены с использованием рентгеновской дифракции (РД), комбинационного рассеяния света и мёссбауэровская спектроскопия. Результаты РД, рамановских и мёссбауэровских исследований указывают, что полученные МНЧ CoxMn1-xFe2O4 являются однофазным. Из РД измерений установлено, что средние размеры кристаллитов CoxMn1-xFe2O4 составляют 34.86 nm для MnFe2O4 (x=0) и при повышении концентрации Co уменьшаются до 14.99 nm для CoFe2O4 (x=1.0). Анализ мессбауровских спектров показал, что средние размеры кристаллитов меняются от 25 nm для MnFe2O4 (x=0) до 12 nm для CoFe2O4 (x=1.0). На спектрах комбинационного рассеяния МНЧ CoxMn1-xFe2O4, в области ~620 cm-1 наблюдается расщепление линии A1g, это означает, что исследуемые МНЧ обладают структурой обратной шпинели. Соотношение интенсивностей пиков A1g (1) и A1g (2) указывает на значительное перераспределение катионов Co2+ и Fe3+ между тетра- и октаэдрическими позициями в МНЧ феррита CoxMn1-xFe2O4, что подтверждается мессбауэровскими данными. Данные мёссбауровсой спектроскопии указывают, что синтезированные МНЧ CoxMn1-xFe2O4 состоят из крупных частиц, обладающих магнитным упорядочением, и мелких частиц находящихся в парамагнитной фазе. С повышением концентрации ионов Mn доля мелких частиц возрастает, что приводит к понижению температуры магнитного блокироввания. Намагниченность насыщения МНЧ при x=0.2 (Co0.2Mn0.8Fe2O4) составляет 57.41 emu/g и этот образец, как было установлено в [V. Narayanaswamy, I.A. Al-Omari, A.S. Kamzin, B. Issa, H.O. Tekin, H. Khourshid, H. Kumar, A. Mallya, S. Sambasivam, I.M. Obaidat. Nanomaterials 11, 1231 (2021)] имеет наибольшее значение удельной скорости поглощения. Как показали мессбауэровские исследования, это связано с тем, что эти частицы находятся в суперпарамагнитном состоянии и температура магнитной блокировки этих МНЧ находится в области ~315 K, наиболее приемлемой для лечения злокачественных опухолей методом магнитной гипертермии. Таким образом, синтезированные МНЧ CoxMn1-xFe2O4 являются перспективными для биомедицинских применений. Ключевые слова: ферриты-шпинели CoxMn1-xFe2O4, магнитная структура, суперпарамагнетимз, мёссбауэровская спектроскопия, материалы для биомедицины.
Модовая бистабильность плазмонов и дисперсионный скачок в структуре с двумя графеновыми слоями
Authors: Шутый А.М. , Семенцов Д.И. , Елисеева С.В.
Published: March 2022

Plasmon modes in a symmetric structure consisting of two layers of inverted graphene separated by a dielectric barrier layer and their dispersion properties are studied for various parameters of the barrier layer. The occurrence of a bifurcation of the splitting of the branch of the dispersion dependence, which leads to the appearance of bistability and a dispersion jump with a change in the stability of the branches included in the bistability, is found. The plasmonic modes belonging to the two branches of the bistable state differ in the gain increment and phase velocity, and their group velocities are opposite in sign.
Взаимодействие атомов Be с поверхностью грани (111) Ir
Authors: Рутьков Е.В. , Афанасьева Е.Ю. , Галль Н.Р.
Published: March 2022

It is shown that, when sputtered onto the surface of the (111) Ir face in the temperature range 1100–1250 K, beryllium atoms form a surface chemical compound of stoichiometry Ir3Be with a concentration of adsorbed beryllium NBe=5•1014 cm–2, after which the newly deposited beryllium atoms dissolve in the volume of the metal . The Ir3Be surface compound itself is destroyed due to the dissolution of beryllium in the temperature range of 1250–1400 K with an activation energy increasing from 3.2 eV to 3.7 eV with decreasing Be concentration. At T>1400 K, the thermal desorption channel is switched on. The formation of the Ir3Be surface compound significantly lowers the energy barrier E for the dissolution of Be atoms in the bulk of iridium by Δ E>1.7 eV.
Efficiency of five-component therapy at refractory arterial hypertension depending on saltsensitivity phenomenon
Authors: Skibitsky V. V. , Garkusha E. S. , Fendrikova A. V. , Kudryashov E. A. , Rabadanov D. A.
Published: March 2022

Objective: assess influence of five-component antihypertensive therapy on the main indicators of the daily monitoring of arterial pressure (DMAP), a structurally functional state and diastolic function of a myocardium at patients with the refractory arterial hypertension (RAH) depending on «saltsensitivity» phenomenon. Material and methods: 88 patients with RAH (54 «salt-sensitive» patients, 34 -«salt-resistant»), receiving as antihypertensive therapy ACE inhibitor, a blocker of slow calcic channels (the digidropiridiny), thiazide diuretics, beta-blocker and direct inhibitor of a renin in full doses are surveyed. To all patients DMAP and an echocardiography till 48 weeks of treatment were carried out. Results: 68,5% of «salt-sensitive» and 79,4% — «salt-resistant» of patients on five-component therapy have reached the target level (TL) the AP. Irrespective of a «saltsensivity» the combination of 5 preparations provided reliable positive changes of all indicators of DMAP and Echo, but thus at «salt-resistant» of patients more expressed positive dynamics of indicators of DMAP, the AP daily profile and a myocardium hypertrophy in comparison with «salt-sensitive» patients is noted. Conclusion: five-component therapy provided more significant antihypertensive and antiremodeling effects at «salt-resistant» of patients with RAH, in comparison with «salt-sensitive».
Evaluation of the effectiveness of thyrostatics in the treatment of comorbid patients with thyrotoxicosis
Authors: Pashchenko E. V. , Chesnikova A. I. , Kudinov V. I. , Safronenko V. A. , Lankina M. S.
Published: March 2022

Objective: to evaluate the effect of thyrostatics on clinical symptoms, the frequency of cardiac arrhythmias and morpho-functional parameters of the left heart in patients with a combination of thyrotoxicosis and ischemic heart failure. Materials and methods: 85 patients participated in the study. Group 1st — patients with CHF of functional class II-III (FC) on the background of coronary heart disease and concomitant thyrotoxicosis (n=40), average age 58.6±4.6 years; group 2nd — patients with manifest thyrotoxicosis without cardiovascular pathology (n=45), average age 46.7± 4.1 years. When included in the study and after 6 months of therapy with the addition of thyrostatics, the clinical condition of patients and physical activity were evaluated, daily monitoring of an electrocardiogram and an echocardiographic study (EchoCG) were performed. Results: after 6 months of combined therapy with the inclusion of thyrostatics against the background of persistent drug-induced euthyroidism, exercise tolerance increased in comorbid patients (group 1) (p<0.001), the severity of clinical symptoms of CHF decreased, and the frequency of cardiac arrhythmias significantly decreased (p<0.05). The analysis of the dynamics of EchoCG results in group 1 patients revealed a significant increase in the index of shock ejection (p=0.04), left ventricular ejection fraction (p=0.01), shock volume (p=0.03), a decrease in the value of myocardial stress (p=0.02) and parameters characterizing the transmittal flow (E/A, p<0.05), which allowed us to judge the improvement of systolic and diastolic function of the left ventricle (LV) under conditions of drug compensation thyrotoxicosis. Conclusion: the inclusion of thyrostatics in combination therapy and normalization of thyroid function contributed to the reduction of clinical symptoms of heart failure, the frequency of cardiac arrhythmias, improvement of systolic and diastolic LV function in comorbid patients with ischemic CHF and concomitant thyrotoxicosis.
The prevalence of asymptomatic hyperuricemia in patients with chronic kidney disease and its effect on the course and prognosis (experience of one center)
Authors: Batiushin M. M.
Published: March 2022

Objective: to analyze the prevalence of asymptomatic hyperuricemia (HU), as well as to assess its relationship with metabolic disorders, pathological conditions and complications in chronic kidney disease (CKD), we conducted a retrospective cohort study in the form of a total cross-section of patients hospitalized in a round-the-clock bed of the nephrology department. Material and methods: 261 patients were included in the study, the average age was 50.9±17.2 (M±SD), there were 261 males and 99 females. The structure of CKD in hospitalized patients was as follows: CKD C1 — 53 patients, C2 — 70 patients, C3A — 46, C3B — 46, C4 — 36, C5 — 7 patients. The study did not include patients diagnosed with gout. Results: the uric acid level in the examined cohort was 369.8±109.7 mmol/L, ranging from 157 to 768 mmol/l. As the glomerular filtration rate (GFR) decreased, the probability of HU increased. With the development and progression of dyslipidemia, there was an increase in the probability of detecting HU. In patients with CKD, an increase in the level of daily proteinuria was also accompanied by an increase in the probability of detecting HU. The risk of progression of CKD to the terminal stages, as well as LVH, arrhythmias, hypertension is associated with high values of uric acid in the blood. Conclusions: the high prevalence of HU in patients with CKD, along with data on its negative impact on the course of CKD, is an important argument in favor of its detection and control. The association of HU with metabolic disorders against the background of high proteinuria explains one of the mechanisms of its detrimental effect on the course of CKD. The influence of HU on the probability of detection of hypertension, LVH, arrhythmias and terminal stages of CKD is shown, which determines the importance of the modifiability of this risk factor in the prognosis of the course of CKD
A case of myocardial infarction due to spontaneous dissection of the coronary artery
Authors: Kholodova V. E. , Namitokov A. M. , Donets E. K. , Kruchinova S. V. , Kosmacheva E. D.
Published: March 2022

Nowadays spontaneous coronary artery dissection is an increasingly recognized cause of an acute coronary syndrome. This article presents data on the epidemiology, predisposing factors, risk groups, factors contributing to the development of this disease. In this article we report the case of a 53-year-old woman with an acute ST-elevation myocardial infarction secondary to a spontaneous dissection of the right coronary artery.
Perception of the Food and Drug Administration Electronic Cigarette Flavor Enforcement Policy on Twitter: Observational Study
Authors: Lu Xinyi , Sun Li , Xie Zidian , Li Dongmei
Published: March 2022

Background

On January 2, 2020, the US Food and Drug Administration (FDA) released the electronic cigarette (e-cigarette) flavor enforcement policy to prohibit the sale of all flavored cartridge–based e-cigarettes, except for menthol and tobacco flavors.

Objective

This research aimed to examine the public perception of this FDA flavor enforcement policy and its impact on the public perception of e-cigarettes on Twitter.

Methods

A total of 2,341,660 e-cigarette–related tweets and 190,490 FDA flavor enforcement policy–related tweets in the United States were collected from Twitter before (between June 13 and August 22, 2019) and after (between January 2 and March 30, 2020) the announcement of the FDA flavor enforcement policy. Sentiment analysis was conducted to detect the changes in the public perceptions of the policy and e-cigarettes on Twitter. Topic modeling was used for finding frequently discussed topics about e-cigarettes.

Results

The proportion of negative sentiment tweets about e-cigarettes significantly increased after the announcement of the FDA flavor enforcement policy compared with before the announcement of the policy. In contrast, the overall sentiment toward the FDA flavor enforcement policy became less negative. The FDA flavor enforcement policy was the most popular topic associated with e-cigarettes after the announcement of the FDA flavor enforcement policy. Twitter users who discussed about e-cigarettes started to talk about other alternative ways of getting e-cigarettes after the FDA flavor enforcement policy.

Conclusions

Twitter users’ perceptions of e-cigarettes became more negative after the announcement of the FDA flavor enforcement policy.
Using Distance Communication for the User-Centered Development of a Smartphone-Based Serious Game for Children With Type 1 Diabetes: Participatory Design Approach (Preprint)
Authors: Nørlev Jannie , Derosche Christina , Sondrup Katrine , Hejlesen Ole , Hangaard Stine
Published: March 2022

BACKGROUND

The complications of type 1 diabetes (T1D) can be delayed or prevented in children with T1D who receive proper self-management education. Smartphone-based serious games are increasingly being used as an effective tool for teaching self-management. When developing a serious game, it is important that the development process be user-centered. Traditionally, different face-to-face methods have been used when children participate in the development process. However, face-to-face data collection is not always feasible. In such situations, distance communication can be used when developing a serious game.

OBJECTIVE

The objective of this study is to develop a user-centered smartphone-based serious game that teaches self-management focused on carbohydrate intake in children aged 8-14 years with T1D using distance communication in both the development and evaluation of the game.

METHODS

The development and evaluation of a smartphone-based serious game prototype was inspired by the Lean principles, and a user-centered approach was applied. The development process included 1 expert interview and design workshops with children with T1D. On the basis of the interview and design workshop results, a serious game prototype was developed using Microsoft PowerPoint. The evaluation of the serious game prototype included an interview with a dietitian and a playtest with children with T1D. All data were collected using distance communication.

RESULTS

A user-centered smartphone-based serious game prototype was developed and evaluated. The expert interview with the dietitian formed the basis for the learning outcomes in the game. Four children and their parents contributed to the preferences, needs, requirements, and ideas for selected parts of the game design. The dietitian evaluated the prototype positively and validated its content and accuracy. The serious game prototype was well-received by the children and their parents during the playtest. The serious game prototype was perceived as a useful and engaging way to learn. However, the difficulty level was not appropriate, and the information was too basic for participants who had been diagnosed over a year ago. The use of digital communication platforms did not cause any problems.

CONCLUSIONS

The smartphone-based serious game prototype has the potential to be a useful and attractive tool for teaching disease self-management. The use of distance communication proved to be a useful approach in the development of a serious game.
Peer Review of “Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-Related Mental Disorders (MIND-SET): Protocol for a Cross-sectional Comorbidity Study From a Research Domain Criteria Perspective” (Preprint)
Authors: Palmer Emma
Published: March 2022

UNSTRUCTURED

This is a peer review report related to MS ID#31269.
Analysing the perspectives of health professionals and legal cannabis users on the treatment of chronic pain with cannabidiol (CBD): A scoping review. (Preprint)
Authors: Kumar Priyanka , Mpofu Charles , Wepa Dianne
Published: March 2022

BACKGROUND

Medical cannabis is one of the most commonly reported therapeutic treatments sought for chronic pain. The wide acceptance and research in alternative medicine has put medical cannabis in the limelight, where researchers are widely examining the therapeutic benefits of medical cannabis and its association to treat chronic pain.

OBJECTIVE

The purpose of this scoping review is to provide an overview of the perspectives on CBD as an alternative treatment for chronic pain among health professionals and legal cannabis users.

METHODS

A comprehensive literature search was performed using over five databases for published literature and then extended to include grey literature. The software Covidence was used to perform a guided screen of titles, abstracts, and full texts for published literature. For grey literature, a range of websites and databases were searched manually. This review includes the studies from New Zealand and Australia, exploring user and health professional perspectives on the use of medical cannabis for chronic pain. The data was analysed using thematic analysis guided by Braun and Clarke [1]

RESULTS

The results of this scoping review are presented in a table summarising the findings which inform the key themes for the discussion.

CONCLUSIONS

The scoping review concludes with future recommendations for research to guide and inform policy in NZ.
Increased serial levels of platelet‐derived growth factor using hypoxic mesenchymal stem cell‐conditioned medium to promote closure acceler‐ ation in a full‐thickness wound
Authors: Drawina Pangesti , Putra Agung , Nasihun Taufiqurrachman , Prajoko Yan Wisnu , Dirja Bayu Tirta , Amalina Nur Dina
Published: March 2022

The healing process of a full‐thickness wound involves a complex cascade of cellular responses to reverse skin integrity formation. These processes require growth factors, particularly platelet‐derived growth factor (PDGF). Conversely, hypoxic mesenchymal stem‐cell‐conditioned medium (HMSC‐CM)‐contained growth factors notably contribute to acceleration of wound healing. This study aims to investigate the role of HMSC‐CM in controlling the serial levels of PDGF associated with accelerated wound closure in full‐thickness wounds. Twenty male Wistar rats with full‐thickness wounds were developed as animal models. The animals were randomly assigned to four groups, comprising two treatment groups (treated using HMSC‐CM at a high dose as P1 and at a low dose as P2), a control group (administration of base gel), and sham group (healthy group). PDGF levels were examined using an enzyme‐linked immunosorbent assay. Using ImageJ software, wound closure percentages were determined photographically. The study showed that there was a significant increase in PDGF levels on days 3 and 6 after HMSC‐CM treatment, followed by a decrease in PDGF levels on day 9. In line with these findings, wound closure percentage also increased significantly on days 6 and 9. In the rat model, HMSC‐CM administration may promote acceleration of wound closure by increasing serial PDGF levels in the full‐thickness wound.
The Effect of the Blue Ocean Strategy on Realizing the Above-Average Model: An Applied Study at Zain Telecommunications—The Case of Iraq
Authors: Naeem Ali M. , Younis Joumana A. , Manhal Mohammad H. , Yassine Mohammad A.
Published: March 2022

The current research aims to analyze the effect of the blue ocean strategy on the model of above-average returns for the purpose of realizing superior revenues for Zain Telecommunications. The research involved 60 officials who filled in a questionnaire which was prepared for this purpose. The data were analyzed by employing the correlation coefficient and regression analysis using SPSS v. 24. The research reached a number of conclusions, the most significant of which were the presence of a significant effect of the blue ocean strategy with its four principles: reduce, raise, eliminate and create in realizing superior returns (above-average) which were translated with its secondary principles: resources, potentials, competitive advantages, attractive industry, preparing and implementing the strategy, and realizing superior returns.
ANALYSIS OF NEONATAL GROWTH IN CAPTIVE DUSKY RATTLESNAKES (Crotalus triseriatus) FROM TWO POPULATIONS IN CENTRAL MEXICO
Authors: Jaramillo Alba José Luis , Pérez Mendoza Hibraim Adán , Días de la Vega Pérez Anibal Helios , Sanabria Tobón Salomón Rubén
Published: March 2022

Body size has important effects on snake ecology, and in turn, body size is dependent on the rate at which individuals grow. In this study, we analyzed first year captive growth of individuals from two populations of the Mexican dusky rattlesnake (Crotalus triseriatus). We used linear models to estimate individual growth rates as well as to compare growth rates between populations and sexes. Birth body size was greater in males than in females, and this pattern remained throughout the experiment. Average growth rate for all individuals was 7.66 mm/month. While the average absolute change was 79.8 mm. No statistical differences were detected in growth rates between populations or sexes. This could indicate that the variation in this attribute may be greater within populations than between populations.
FIRST RECORD OF A DEFENSIVE BEHAVIOR IN Microcaecilia nicefori (GYMNOPHIONA: SIPHONOPIDAE) PROVOKED BY THE SNAKEBITE OF Micrurus dumerilii (SERPENTES: ELAPIDAE)
Authors: Fernandez Juan David , Gómez Sánchez Diego
Published: March 2022

We here report the first dynamic event of predation and defensive behavior in Microcaecilia nicefori provoked by Micrurus dumerilii in Armero, Tolima, Colombia, and we also provide a compendium of all the available literature records of caecilians being preyed upon by snakes in the Neotropic.
ACCIDENTAL DEATH OF AMAZON TURTLE Podocnemis expansa (TESTUDINATA: PELOMEDUSIDAE) DURING SPAWNING ON THE CRIXÁS-AÇÚ RIVER IN GOIÁS, BRAZIL
Authors: Vaz Ribeiro Maurivan Vaz , Caetano Leo , Lopes Ribeiro Paulo , Martins Lopes Baptista Luíz Alfredo , Pastori Lara Mariana , Malvasio Adriana , Schiavetti Alexandre
Published: March 2022

We present an important event not yet reported of accidental death by burying Podocnemis expansa by grounding caused by other breending females. This event possibly occurred during the previous night, during the spawning peak activity on this beach with approximately 1,500 spawns, many of them overlapping. Any predatory event was not considered, as the turtles were intact, unmarked and buried, which is unusual. In general, they choose higher places on the beaches, increasing the chances of survival of the young due to the seasonality (high and low flows) of the rivers, with the nesting on the Crixás-Açu River during the dry season. However, this is the first report of accidental death of turtles by other changes during the reproductive period and can help to better understand the processes behind the competition for nests on spawning beaches.
Covid 19 Data Analysis in India Using Linear and Polynomial Regression Algorithms
Authors: Rahangdale Ekta , More Sujata , Narnaware Shipali , Sahu Gayatri , Gujar Sayali
Published: March 2022

Abstract: In past two years there is a pandemic called covid-19, which has shook the world. The world has suffered a lot and suffering till now by the disastrous effect of corona virus globally. It has affect the world in all parameter i.e. economically, mentally and so on. The world don't when will this pandemic end yet can make forecast by utilizing AI calculations to make moves in the event that this occurs in later days ,how might human and government make counteractions from Covid. This project “Analysis on covid-19 in India using Linear and Polynomial algorithms” analyze the covid-19 datasets from 01-03-2021 to 08-05-2021 for India and also for its top 4 states ,having more number of confirmed cases and predicted the results by using machine learning algorithms (linear regression and polynomial regression with degree of 5).The predicted results will be helpful for government to take actions against this pandemic. Keywords: Data Analysis, Linear Regression, Polynomial Regression, Preprocessing of data, Flask
Blockchain Voting: A Comparative Analysis
Authors: Viji Dr. C. , Kumar Akash , Noorayen Ayesha , Amjad Humera , Abrar Mohammed
Published: March 2022

Abstract: The electronic voting has emerged over time as a replacement to the paper-based voting to reduce the redundancies and inconsistencies. The historical perspective presented in the last two decades suggests that it has not been so successful due to the security and privacy flaws observed over time. This project is about decentralizing authority to record, count and verify votes and the voters, rather than having a central authority. We are using blockchain technology which is a distributed database. With its immutability property and decentralized architecture, it can run and support a voting scheme that is open, fair and independently verifiable. The project will be developed in Ethereum framework which primarily uses Solidity as a language. Ethereum’s backbone is its decentralized virtual machine called Ethereum Virtual Machine. The application will be deployed on the thirdweb(web3.0). Overall this project is a potential roadmap for blockchain technologies developing in the nation to support complex applications. Keywords: Blockchain, Cryptography, Cryptocurrency, Ethereum Framework, Solidity, Decentralization, Hashing, Dapp, Web3, Digitalizing.
Implementation of Metro Rail Project in Pune City
Authors: Yadav Sarika
Published: March 2022

Abstract: In India, around 26 metro rail projects are in various phases of planning, construction, and operation. A number of new metro rail phases are being planned and will be operational in the near future. Various studies have revealed delays in metro rail project planning and execution in India and around the world. This research will attempt to comprehend a wide range of subjects. There are numerous alternatives for dealing with problems or impediments that the metro rail corporation encounters when constructing metro rail projects. Variables that may impede project execution, such as government funding capability, financial arrangements, and so on. To name a few, competing technologies, a workable operating plan, and stakeholder issues. The factors that determine metro rail operations The Pune Metro Rail Project will be utilized to examine potential projects. The scope of the study will be limited to mobilization. The study approach is centered on formal contacts with participants from the planning phase to the commissioning phase. The study's conclusions are crucial in various ways for Pune Metro Rail Corporation decision makers and project execution group. Developing procedural routines to help metro rail projects be completed more quickly and effectively. Keywords: Implementation of Pune Metro, Delay in the project, Infrastructure of the project, cost
Women Well-being Application
Authors: Khatri Iqra , More Jyotsna , Soni Priya , Satoskar Jatin
Published: March 2022

Abstract: Safety and security of girls is one of the most serious issues of our time; the crime rate is rapidly rising, and female wellbeing has become a greater concern than ever before in today's world. Many studies show that the majority of crimes occur late at night, but women are unable to shut themselves in from twilight till dawn. Women can't expect to work exclusively the day shift in metropolitan places, where offices, convenience stores, gas stations, and other businesses are open 24 hours a day, seven days a week. In the last five years, the use of smart phones with GPS navigation systems has risen significantly. So, if mobile phones are used for so many other purposes, why not women's security? As a result, a smart phone can be effectively employed for personal safety or a variety of other protection objectives, particularly for women. This application alerts the guardians with just a single click. SMS with the user's live location is sent to the preconfigured contact. An alarming siren goes on when the user activates the app. This application also enlists the nearby hospitals and police stations. As a result, this app has the potential to significantly assist in the rescue of women from dangerous situations. Keywords: Smartphone, Android, GPS (Global Positioning System), Alert Message, Panic Button, Safety Tips, Women Security
Marcos discursivos de un movimiento ecologista emergente y su impacto virtual
Authors: Belli Simone , Revilla Juan Carlos , Sánchez Díez Sara , Gonzalo Puyod Alejandro
Published: March 2022

El surgimiento de Fridays for Future (FfF) ha supuesto cambios en los discursos tradicionales en torno al cambio climático. Esto viene acompañado de nuevas estrategias comunicativas a través de las redes virtuales que han tenido bastante repercusión social, con un importante componente emocional basado en el concepto de emergencia climática. El objetivo de este artículo es el análisis de esta dimensión comunicativa a través de sus marcos discursivos y su uso en las redes, utilizando una metodología mixta basada en el trabajo etnográfico y un análisis de redes del movimiento (Twitter). Los resultados reflejan tres aspectos de su discurso que destacan respecto a lo que había recogido la literatura sobre marcos ecológicos anteriores: el énfasis en la emergencia climática frente a la sostenibilidad, el paso de las conductas individuales a la necesidad de transformación sistémica y, por último, su igualitarismo radical. Twitter se utiliza sobre todo para la información de movilizaciones recurriendo a los marcos del cambio de sistema y la emergencia climática, lo que consigue una repercusión menor que los mensajes sobre denuncia o divulgación de información ecológica. Estos últimos remiten con más frecuencia a marcos de justicia ecosocial, cambio climático y futuro en riesgo.