bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression of HER2/c-erbB-2, EGFR protein in gastric carcinoma and its clinical significance
Authors: Cheng Guoxiong , Mei Yijun , Pan Xiaoming , Liu Ming , Wu Suping
Published: May 2019

Objective

To investigate the HER2/c-erbB-2, epidermal growth factor receptor (EGFR) protein expression in gastric cancer and association with patients’ clinical pathology characteristics and prognosis.

Methods

HER2/c-erbB-2 and EGFR protein expression was examined by immunohistochemical assay in gastric cancer tissue and corresponding paired normal gastric tissue of 67 patients of gastric carcinoma. The HER2/c-erbB-2, EGFR protein positive expression rate in cancer tissue and normal gastric tissue were compared. The correlation between HER2/c-erbB-2, EGFR protein positive expression and patients’ clinical pathology characteristics and survival was evaluated.

Results

The positive expression rate of HER2/c-erbB-2 in the cancer and paired normal gastric tissues were 32.8% (22/67) and 4.5% (3/67), respectively with statistical difference (p<0.05). And the positive expression rate of EGFR in cancer and paired normal gastric tissues were 41.8% (28/67) and 5.9 (4/67), respectively, with statistical difference (p<0.05). HER2/c-erbB-2 positive expression in cancer tissue was significant correlated with the pathology grading (p<0.05), tumor invasion depth (p<0.05) and local regional lymph node metastasis (p<0.05); EGFR positive expression in cancer tissue was significant correlated with the tumor invasion depth (p<0.05) and local regional lymph node metastasis (p<0.05). The median survival time was 13.14 and 23.6 months respectively for HER2/c-erbB-2 positive and negative expression groups respectively with statistical difference ( HR=2.26, 9%CI:1.06-4.80, p<0.05). However, the median survival time was 15.47 and 22.87 months for EGFR positive and negative expression groups respectively, without statistical difference (HR=1.78, 9%CI:0.96-3.29, p>0.05).

Conclusion

Positive expression of HER2/c-erbB-2 and EGFR proteins in cancer tissue was significant higher than normal gastric tissue and have significant correlation with prognosis.
Seaweed resources of Mexico: current knowledge and future perspectives
Authors: Vázquez-Delfín Erika , Freile-Pelegrín Yolanda , Pliego-Cortés Hugo , Robledo Daniel
Published: May 2019

High diversity of marine macroalgae is reported for Mexican coasts, including numerous endemic species. Seaweed research in Mexico has focused on the northern regions of the Pacific coast (Temperate Pacific and Gulf of California) and on the Mexican Caribbean coast, leaving aside other regions (Tropical Pacific and Gulf of Mexico). Utilization of seaweed resources within the country has been based on artisanal collection of wild populations mainly for polysaccharide extraction, fertilizers, raw material for animal feed and cosmetic products. The main exploitation has occurred along the coasts of Baja California peninsula, based on few species (Gelidium robustum, Macrocystis pyrifera, Chondracanthus canaliculatus and Gracilariopsis lemaneiformis). Governmental regulations for management have allowed harvesting to reach approximately 11,500 wet tons per year (2013–2016). Nevertheless, in recent years (2014–2016) the total seaweed import volume has increased (5302 tons per year in average) over the export volume (2156 tons per year in average), suggesting a notably growing demand for seaweed resources in the country and representing an opportunity for investment projects. Several pilot studies on seaweed cultivation in Mexico propose that sustainable aquaculture techniques could complement the harvest in natural populations and ensure a homogeneous production with high quality in the long term.
Comparison of a new rapid method for the determination of adalimumab serum levels with two established ELISA kits
Authors: Laserna-Mendieta Emilio J. , Salvador-Martín Sara , Arias-González Laura , Ruiz-Ponce Miriam , Menchén Luis A. , Sánchez César , López-Fernández Luis A. , Lucendo Alfredo J.
Published: May 2019

Background

Therapeutic drug monitoring (TDM) of adalimumab (ADA) in inflammatory bowel diseases (IBDs) has gained increased attention since several studies showed a correlation between drug levels and mucosal healing. The limitations of routine usage of enzyme-linked immunoabsorbent assay (ELISA) kits for measuring serum ADA concentrations have prompted the development of rapid methods, such as Quantum Blue (QB). We evaluated the interchangeability and agreement between the QB method and two established ELISA kits, Promonitor (PM) and Lisa-Tracker (LT).

Methods

Fifty samples from patients with IBD were included. Quantitative analysis was performed using the ANOVA test for repeated measures, Deming regression and the Bland-Altman plot. Clinical implications were evaluated by concordance in classifying patients into therapeutic windows according to the proposed cut-off levels for subtherapeutic (either <5 or <7.5 μg/mL) and supratherapeutic (>12 μg/mL) ranges.

Results

Statistical differences were detected between the QB method and the two ELISA kits, with QB overestimating ADA serum values compared to them. A lack of interchangeability was observed between methods, with greater differences as ADA levels increased. An analysis of a sub-set of samples with ADA values below 9 μg/mL (n = 25) showed that QB fulfilled the criteria to be interchangeable with the LT assay. Concordance for patient classification into ADA therapeutic windows was better for QB vs. LT than for QB vs. PM, with high agreement (>75%) for subtherapeutic levels among the three methods.

Conclusions

Although quantitative differences existed between the rapid method and ELISA kits that hampered their interchangeability, the agreement for identifying patients with subtherapeutic values of ADA was high.
Entrepreneurial Orientation and Performance in South Korea: The Mediating Roles of Dynamic Capabilities and Corporate Entrepreneurship
Authors: Lim Euncheon , Kim Dohyeon
Published: May 2019

Although a cumulative body of literature explains entrepreneurial orientation (EO) and firm performance, there remain differing views on the mechanisms underlying this relationship. The purpose of this study is to investigate the effect of EO on firm performance by considering the roles of dynamic capabilities (DC) and corporate entrepreneurship (CE). We propose that DC and CE mediate the relationship between EO and firm performance, and our empirical results support these propositions. This study fills a gap in the literature on the EO–performance relationship by considering the linkages among disposition, capabilities, and activities in the South Korean context.
The Implications of Brexit for Financial Markets: Towards a Network of EU Financial Centres
Authors: Wuermeling Joachim
Published: May 2019

The departure of the global financial centre in London from the EU raises fundamental questions about the future of the European financial market. But we should refrain from discussing which European financial centre will get which part of the London pie. Instead, we ought to be asking: How can we develop a European financial system that spreads investment and risk among many strong shoulders?
Women’s reproductive health needs assessment questionnaire: development and validation
Authors: Rezaie-Chamani Sedighe , Rahnavardi Mona , Bostani Khalesi Zahra
Published: May 2019

Background

Assessment of reproductive health (RH) needs is necessary for describing the status of women’s RH and identification of the actions needed. This study aimed to develop and validate a questionnaire for the assessment of the women’s RH needs.

Materials and methods

A sequential exploratory mixed method study (qualitative and quantitative) was conducted with Iranian women of reproductive age (age 15–49 years) living in Rasht. The qualitative exploratory phase was used to explain the concept and dimensions of RH needs. The qualitative exploratory phase was used to develop and validate a questionnaire.

Results

The results of the qualitative section, RH needs consists of two themes “Reproductive Health Education Needs” and “Reproductive Health Services Features”. A Women’s Reproductive Health Needs Assessment Questionnaire (WRHNAQ) was designed with 19 items. The content validity ratio (CVR) and content validity index (CVI) of the questionnaire were 0.89 and 0.93, respectively. The instrument’s internal consistency was confirmed by an alpha coefficient of 0.881.

Conclusion

The results of this study showed that the WRHNAQ is a culturally sensitive, valid and reliable scale for assessing the RH needs. The WRHNAQ will be helpful for identifying needs and need-based intervention.
Control survey for a 6.7 km immersed tunnel in Chinese Lingding ocean
Authors: Li Guanqing , Huang Shengxiang
Published: May 2019

The immersed tunnel which is composed of elements has drawn more attention nowadays because of new advancements and developments. The elements are prefabricated somewhere else and floated to the tunnel site to be sunk into the prepared trench. Each element must line up exactly for the watertight gaskets to seal properly. The HZM immersed tunnel, a key part of the Hong Kong-Zhuhai-Macao Bridge (HZMB) that crosses the Pearl River Estuary and links Hong Kong to the east, and Zhuhai and Macao to the west, is 6.7 km long, one of the longest immersed tunnel ever realized in the world. For the construction of such a mega immersed tunnel, particular care should be taken in the perspective of geodetic control. This paper described the design and implementation of the geodetic basis and hierarchical surface control networks. And to decrease the influence of lateral refraction and to improve the configuration strength and increase the number of redundant observation compared with traverse, the design of underground surveying network named duo-linear joint chain and the results of gyro checks are presented. In the end HZM immersed tunnel surveying data is analyzed and the performance of the control networks is demonstrated.
Transient neonatal hypothyroidism following a short course of maternal amiodarone therapy
Authors: Huang Victoria , Wolf Risa M.
Published: May 2019

Background

Amiodarone is an iodine-rich medication used to treat maternal and fetal arrhythmias, with known effects on thyroid hormone homeostasis.

Case presentation

We describe a case of transient neonatal hypothyroidism following a short prenatal course of maternal amiodarone therapy resulting in neonatal TSH elevations exceeding those reported in the available literature.
Self-rated Tanner stage and subjective measures of puberty are associated with longitudinal gonadal hormone changes
Authors: Balzer Ben W.R. , Garden Frances L. , Amatoury Mazen , Luscombe Georgina M. , Paxton Karen , Hawke Catherine I. , Handelsman David J. , Steinbeck Katharine S.
Published: May 2019

Introduction

In large community-based studies of puberty, Tanner staging by a clinician is often not possible. We compared self-rated Tanner staging and other subjective ratings of pubertal development with serum hormone levels measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to reassess the utility of self-rated pubertal stage using highly sensitive and specific hormone analysis.

Methods

Adolescents and their parents enrolled in the Adolescent Rural Cohort study of Hormones and health, Education, environments and Relationships (ARCHER) answered annual survey questions on pubertal development. Annually, adolescents provided blood samples for serum testosterone and estradiol measured by LC-MS/MS.

Results

Longitudinally, self-rated Tanner stage was positively associated with serum testosterone and estradiol levels in both sexes. Confirmation by adolescent and parent that puberty had commenced was associated with higher gonadal hormone levels in both sexes. Parent and adolescent responses demonstrated ‘fair’ to ‘moderate’ agreement.

Conclusions

Over a 3-year follow-up, self-rated Tanner staging and simple questions regarding pubertal onset and development are positively associated with adolescent gonadal hormone concentrations in serum measured by mass spectrometry. Thus, self-report of puberty stage still has a role in large community-based studies where physical examination is not feasible.
Kant and the Understanding’s Role in Imaginative Synthesis
Authors: Arens Patrick E.
Published: May 2019

The aim of this article is to contribute to the ongoing debate about whether Kant is a conceptualist or a non-conceptualist, by criticizing Hannah Ginsborg’s conceptualist interpretation found in her “Was Kant a nonconceptualist?” (2008). Ginsborg’s conceptualist interpretation places important focus on imaginative synthesis. According to Ginsborg, our being conscious of imaginative synthesis is an essential element of such processes and it is our consciousness that confers intentionality to synthesized representations. In this article, I undermine Ginsborg’s account by offering several passages that challenge its central tenets. Then, I develop and argue for an interpretation of imaginative synthesis that respects the passages used against Ginsborg. In short, I think the original text supports an account of synthesis such that the manifold of intuitions produced by our faculty of sensibility is unconsciously synthetically unified by the imagination. It is important to note that while the interpretation I offer here does not decisively support a conceptualist or non-conceptualist interpretation of Kant, it is nevertheless favorable to both the content and state non-conceptualist readings and unfavorable to the Ginsborgian conceptualist reading; this is because my interpretation shows that the mere fact of imaginative synthesis does not itself entail conceptualism, as Ginsborg maintains.
Pure Reason’s Enlightenment: Transcendental Reflection in Kant’s first Critique
Authors: Boer Karin de
Published: May 2019

In this article I aim to clarify the nature of Kant’s transformation of rationalist metaphysics into a science by focusing on his conception of transcendental reflection. The aim of Kant’s Critique of Pure Reason, it is argued, consists primarily in liberating the productive strand of former general metaphysics - its reflection on the a priori elements of all knowledge - from the uncritical application of these elements to all things (within general metaphysics itself) and to things that can only be thought (in special metaphysics). After considering Kant’s conception of metaphysics and his various uses of the term ‘transcendental’ I closely examine his account of logical and transcendental reflection in the section entitled ‘On the Amphiboly of the Concepts of Reflection’. Whereas commentators generally attribute the activity called transcendental reflection to Kant alone, I contend, first, that Kant regarded philosophy as such to rely on a mode of transcendental reflection and, second, that the critical mode of transcendental reflection enacted in the Critique itself yields insight into the reason why our a priori knowledge is limited to the realm of possible objects. This is illustrated by outlining the difference between Kant’s and Leibniz’ employment of the concepts of reflection.
Kant on the Soul’s Intensity
Authors: Chepurin Kirill
Published: May 2019

In this paper I propose to consider a certain set of notions in Kant as subsumable under a single notion - that of the soul’s intensity - as well as the possibility of a transcendental grounding of this notion within Kant’s critical framework. First, I discuss what it means for Kant to attribute intensive magnitude to the soul, starting with his response to Mendelssohn where Kant introduces the soul’s intensity as a metaphysical notion immanent to the principles of rational psychology. I show, however, that in Kant’s counter-argument there occurs a subtle though crucial shift in perspective - from the soul’s substance to its powers. Then I move on to consider three fundamental variants upon the soul’s intensity - intensities of representation, of life, and of cognition - each governed, I argue, by the implied notions of measure of intensity and its balance. Also, I examine Kant’s accounts of the life of a species and the necessity of sickness; of intensity of “enlightenment” in a society and the benefit of ignorance; and of sermon as a practical exertion of cognition’s intensity. Next, the aforementioned shift of emphasis allows me to demonstrate that the notion of the soul’s intensity can indeed be transcendentally justified by appealing to Kant’s principle of the Anticipations of Perception. Finally, I conclude with an appendix on the possible connection of the soul’s intensity to Kant’s aesthetics.
Kant’s conception of self as subject and its embodiment
Authors: Onof Christian
Published: May 2019

This paper examines Kant’s conception of the self as subject, to show that it points to an understanding of the self as embodied. By considering ways in which the manifold of representations can be unified, different notions of self are identified through the subjective perspectives they define. This involves an examination of Kant’s distinction between subjective and objective unities of consciousness, and the notion of empirical unity of apperception in the first Critique, as well as the discussion of judgements of perception and judgements of experience in the Prolegomena. If this identifies the self as subject through its embodied perspective, it leaves open the question of the self’s existence. The paper proposes an interpretation of Kant’s brief statements on this matter which provides grounds for an existence claim that extends to the embodied self. This suggests considering Kant’s view of the certainty of one’s existence as involving a feeling of self, albeit in a specifically Kantian form drawing on the transcendental unity of apperception. This feeling of self introduces a practical dimension that supports the claim that any determination of the self as subject has to be practical, namely as free agent subject to inclinations, insofar as he is embodied.
Synthesis and crystal structure of bis{((E)-((4-((E)-1-(benzyloxyimino)ethyl)phenyl)imino)methyl)-2-phenolato-κ2
N,O}copper(II), C44H38CuN4O4
Authors: Huang Jing , Ma Jin-Xia , Wei Ping , Zhao Ji-Xing
Published: May 2019

C44H38CuN4O4, monoclinic, P21/n (no. 14), a = 8.0172(13) Å, b = 10.9003(17) Å, c = 42.154(8) Å, β = 94.749(6)°, Z = 4, V = 3671.2(11) Å3, R
gt(F) = 0.0483, wR
ref(F
2) = 0.1072, T = 173(2)K.
Crystal structure of dichlorido-(μ2-2,2′-(diazene-1,2-diyl)bis(benzen-1-ido)-κ2
C:C′)dimercury(II), C12H8Cl2Hg2N2
Authors: Zhao Ying
Published: May 2019

C12H8Cl2Hg2N2, triclinic, P1̄ (no. 2), a = 3.9815(8) Å, b = 8.9837(18) Å, c = 9.755(2) Å, α = 102.10(3)°, β = 99.54(3)°, γ = 98.82(3)°, V = 329.98(12) Å3, Z = 1, R
gt(F) = 0.0368, wR
ref(F
2) = 0.1061, T = 296(2) K.
Crystal structure of tetrabutylammonium 4,4-oxydibenzoate – boric acid – water (1/2/6) C46H98B2N2O17
Authors: Cui Yongxia , Chen Xiaohui , Zhang Tingting
Published: May 2019

C46H98B2N2O17, orthorhombic, Pbca (no. 61), a = 16.485(3) Å, b = 17.441(3) Å, c = 41.100(7) Å, V = 11817(3) Å3, Z = 8, R
gt(F) = 0.0516, wR
ref(F
2) = 0.1557, T = 296(2) K.
Crystal structure of 4-isobutoxybenzaldehyde oxime, C11H15NO2
Authors: Tang Xian , Wang De-Cai
Published: May 2019

C11H15O2N, monoclinic, P21/n (no. 14), a = 13.5152(2) Å, b = 6.19120(10) Å, c = 14.3917(2) Å, β = 115.467(2)°, V = 1087.22(3) Å3, Z = 4, R
gt(F) = 0.0384, wR
ref(F
2) = 0.1104 T = 170(2) K.
Obstructive sleep apnea: personal, societal, public health, and legal implications
Authors: Morsy Nesreen E. , Farrag Nesrine S. , Zaki Nevin F.W. , Badawy Ahmad Y. , Abdelhafez Sayed A. , El-Gilany Abdel-Hady , El Shafey Mohsen Mohammed , Pandi-Perumal Seithikurippu R. , Spence David Warren , BaHammam Ahmed S.
Published: May 2019

Introduction

Obstructive sleep apnea (OSA) is a widely prevalent sleep-related breathing disorder, which leads to several life-threatening diseases. OSA has systemic effects on various organ systems. Untreated OSA is associated with long-term health consequences including hypertension, heart disease, diabetes, depression, metabolic disorders, and stroke. In addition, untreated OSA is reported to be associated with cognitive dysfunction, impaired productivity at the workplace and in an increased risk of motor vehicle accidents (MVAs) resulting in injury and fatality. Other consequences of OSA include, but are not limited to, impaired vigilance, daytime somnolence, performance deficits, morning headaches, mood disturbances, neurobehavioral impairments, and general malaise. Additionally, OSA has become an economic burden on most health systems all over the world. Many driving license regulations have been developed to reduce MVAs among OSA patients.

Methods

Studies of the personal, societal, public health, and legal aspects of OSA are reviewed. Data were collected through the following databases: MEDLINE, Google Scholar, Scopus, SAGE Research Methods, and ScienceDirect.

Conclusion

OSA leads to worsening of patients’ personal relationships, decreasing work productivity, and increasing occupational accidents as well as MVAs. The costs of undiagnosed and untreated OSA to healthcare organizations are excessive. Thus, proper management of OSA will benefit not only the patient but will also provide widespread benefits to the society as a whole.
Response to Critics
Authors: Olen Peter
Published: May 2019

All contributions included in the present issue were originally prepared for an “Author Meets Critics” session organized by Carl Sachs for the Eastern Division Meeting of the American Philosophical Association in Savannah, Georgia, on 5th January, 2018.
Mindsets of Addiction: Implications for Treatment Intentions
Authors: Burnette Jeni L. , Forsyth Rachel B. , Desmarais Sarah L. , Hoyt Crystal L.
Published: May 2019

Introduction: The goal of the current work is to contribute to the critical dialog regarding consequences of different communications about the nature of addiction by offering a new theoretical approach. Specifically, we merge a mindset perspective, which highlights the importance of beliefs regarding the malleability of human attributes, with the attribution literature to explore how messages stressing the changeable vs. fixed nature of addiction influence beliefs and treatment intentions.

Method: We crafted a message about addiction designed to induce the belief in the potential to change without influencing self-blame (compensatory-growth mindset message) and compared it to a message focused on the fixed underpinnings of addiction (disease-fixed mindset message).

Results: In an online sample of probable substance users (N = 214), we found that the compensatory-growth, relative to the disease-fixed message, led to participants reporting stronger growth mindsets and efficacy without an impact on blame. Additionally, the compensatory-growth, relative to the disease-fixed message, led to stronger intentions to pursue counseling and cognitive behavioral treatment therapies.

Discussion: The current work finds support for an innovative theoretical approach for understanding motivation to seek treatment among individuals with probable substance use problems.
Prevalence of celiac disease and celiac-related antibody status in pediatric patients with type 1 diabetes in Jordan
Authors: Odeh Rasha , Alassaf Abeer , Gharaibeh Lubna , Ibrahim Sarah , Khdair Ahmad Fareed , Ajlouni Kamel
Published: May 2019

Objective

Scientific findings regarding the prevalence of celiac disease (CD) in pediatric patients with type 1 diabetes (T1D) in the Arab world are scarce. We aimed to determine the prevalence of biopsy-proven celiac disease (BPCD) among pediatric patients with T1D from Jordan. We also assessed the possible predictors for developing CD in this cohort of patients and we compared T1D patients who developed BPCD with those who had positive CD serology but negative histology and/or fluctuating CD serology.

Methods

Celiac serology and duodenal biopsy results from 2012 to 2017 were collected from patients with T1D. The outcome of positive celiac serology and the risk factors for CD in T1D patients were investigated.

Results

A total of 538 children of which 278 boys (51.7%) were included in the study. The prevalence of positive serology and the diagnosis of BPCD in this cohort of T1D patients were 16.6 and 9.1% respectively. Eighty percent of those with BPCD were asymptomatic and 47% were diagnosed with CD at onset of T1D. Spontaneous normalization of celiac serology occurred in 23.6% of those with positive serology.

Conclusion

CD is prevalent in T1D pediatric patients from Jordan (9.1%). It is often asymptomatic and the majority of cases were diagnosed at onset or within 5 years of T1D diagnosis. Spontaneous normalization of CD serology occurred in some patients with T1D. Hence, a watchful follow-up is recommended in such patients.
Impact of exenatide on mitochondrial lipid metabolism in mice with nonalcoholic steatohepatitis
Authors: Kalavalapalli Srilaxmi , Bril Fernando , Guingab Joy , Vergara Ariana , Garrett Timothy J , Sunny Nishanth E , Cusi Kenneth
Published: May 2019

Exenatide (Exe) is a glucagon-like peptide (GLP)-1 receptor agonist that enhances insulin secretion and is associated with induction of satiety with weight loss. As mitochondrial dysfunction and lipotoxicity are central features of nonalcoholic steatohepatitis (NASH), we tested whether Exe improved mitochondrial function in this setting. We studied C57BL/6J mice fed for 24 weeks either a control- or high-fructose, high-trans-fat (TFD)-diet (i.e., a NASH model previously validated by our laboratory). For the final 8 weeks, mice were treated with Exe (30 µg/kg/day) or vehicle. Mitochondrial metabolism was assessed by infusion of [13C3]propionate, [3,4-13C2]glucose and NMR-based13C-isotopomer analysis. Exenatide significantly decreased fasting plasma glucose, free fatty acids and triglycerides, as well as adipose tissue insulin resistance. Moreover, Exe reduced 23% hepatic glucose production, 15% tri-carboxylic acid (TCA) cycle flux, 20% anaplerosis and 17% pyruvate cycling resulting in a significant 31% decrease in intrahepatic triglyceride content (P = 0.02). Exenatide improved the lipidomic profile and decreased hepatic lipid byproducts associated with insulin resistance and lipotoxicity, such as diacylglycerols (TFD: 111 ± 13 vs Exe: 64 ± 13 µmol/g protein,P = 0.03) and ceramides (TFD: 1.6 ± 0.1 vs Exe: 1.3 ± 0.1 µmol/g protein,P = 0.03). Exenatide lowered expression of hepatic lipogenic genes (Srebp1C,Cd36) and genes involved in inflammation and fibrosis (Tnfa,Timp1). In conclusion, in a diet-induced mouse model of NASH, Exe ameliorates mitochondrial TCA cycle flux and significantly decreases insulin resistance, steatosis and hepatocyte lipotoxicity. This may have significant clinical implications to the potential mechanism of action of GLP-1 receptor agonists in patients with NASH. Future studies should elucidate the relative contribution of direct vs indirect mechanisms at play.
Professionalism Kills the Trading Star: Explaining Member Participation in Trading Communities
Authors: Benoit Sabine , Hogreve Jens , Sichtmann Christina , Bilstein Nicola
Published: May 2019

Trading communities provide non-commercial members with an online platform on which to exchange goods. Its success depends on member participation; however, little is known about its drivers. Based on literature we identify five drivers. To capture their impact over time,we test a latent growth curve model with longitudinal data, comparing the effects at an initial point of time with their impact on the growth of member participation over three subsequent periods. The results show that providers’ responsiveness and community identification have a positive effect on the initial level, but not on growth. Members’ enjoyment has no level effect, but a growth effect. Only role clarity has an impact on level and growth. Interestingly, co-members’ cooperation weakens member participation, which leads us to conclude that too much cooperation – which appears as professionalism in a trading community – ‘kills’ member participation. We conclude with theoretical and managerial implications.
Cryptocurrency: Advantages and Disadvantages
Authors: Subačius Augustas , Subačienė Rasa
Published: May 2019

[full article and abstract in Lithuanian; abstract in English]

The main feature of the twenty-first century could be named as permanent transformation that covers all areas. Payments and money are developing and changing especially fast. Technological evolution and development have led to the emergence of new transactional techniques on the Internet, mobile phones, and credit cards. Various systems of payment / money transfer have considerably expanded payment options and possibilities. And such conditions have created opportunities for the emergence of a cryptocurrency. The purpose of the study is to investigate the cryptocurrency, its concept, advantages and disadvantages. Analysis of the scientific literature, systematization, comparison, interpretation and generalization of information research methods were used for the study. Evaluation of the reasons for the emergence of cryptocurrency let to generalise, that the process was mostly influenced by technological progress and the aspiration to find faster, cheaper and more confidential settlement tools. Cryptocurrency may be defined as digital money or property in electronical form. This currency may be characterized by properties of decentralization, uncontrollability and higher risk management. The most important advantages of using a cryptocurrency may be: the speed of settlements; cheaper financial services; additional investment opportunities. Disadvantages - unpredictable, fluctuating value; possible fraud cases; possibility to use cryptocurrency for illegal activities.
Roboto asistuojama totalinė histerektomija: pirmoji patirtis
Authors: Šiaulys Raimondas
Published: May 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]

Straipsnyje retrospektyviai analizuojamos Klaipėdos universitetinėje ligoninėje atliktos pirmosios 23 totalinės histerektomijos, naudojant Senhance® robotinę sistemą. Pacientės operuotos dėl gimdos vėžio, miomatozės, endometriozės, profilaktiškai po krūties vėžio gydymo ir atskirais atvejais esant gimdos kaklelio patologijų ar nustačius gerybinį kiaušidžių naviką. Aptariama operacijų atlikimo technika, pateikiami rezultatai. Išvados. Roboto asistuojama totalinė histerektomija – metodas, saugus pacientėms ir komfortiškas chirurgui.
Robotinė pieloplastika: klinikinio atvejo analizė
Authors: Jasėnas Marius , Venckus Raimundas
Published: May 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]

Dėl geresnių operacinių ir pooperacinių rezultatų urologai vis dažniau atlieka minimaliai invazyvias operacijas. Robotinė pieloplastika – vienas iš metodų, kuris palengvina pielourterinio segmento susiuvimą. Ši operacija mažiau vargina operuojantį gydytoją, trumpėja operacijos ir hospitalizacijos laikas.

2019 m. sausio 4 d. Klaipėdos universitetinėje ligoninėje atlikta pirmoji robotinė (Senhance Transenterixsistema) pieloplastika. Operuota 61 m. pacientė, turėjusi sunkių gretutinių ligų. Operacinis ir pooperacinis periodai praėjo be komplikacijų, ketvirtą parą pacientė išrašyta į namus. Po dviejų mėnesių pacientė kliniškai nusiskundimų neturėjo, atlikus KT tyrimą, nustatyta regresuojanti hydronefrozė po robotinės pieloplastikos.

Įvertinus gautus rezultatus, galima teigti, kad robotinė pieloplastika yra minimaliai invazyvus, saugus ir efektyvus chirurginis metodas, išsiskiriantis labai greita paciento reabilitacija.
Use of Cardiac MRI to Assess Antitumor Efficacy of Everolimus in Sporadic Cardiac Rhabdomyoma
Authors: Davis Kyle A. , Dodeja Anudeep K. , Clark Abigail , Hor Kan , Baker Peter , Cripe Linda H. , Cripe Timothy P.
Published: May 2019

Cardiac rhabdomyoma is the most common neonatal cardiac tumor and is typically associated with tuberous sclerosis complex (TSC). Although these tumors may naturally regress, some patients require surgical resection because of cardiac instability. If not fully resected, patients may also require medical therapy to improve their hemodynamics. Everolimus, a mammalian target of rapamycin inhibitor, has shown promise in reducing rhabdomyoma in patients with TSC, but the drug’s impact in patients without TSC has not been reported. Monitoring of tumor response has typically been limited to echocardiograms, which is not ideal given inherent difficulties in three-dimensional measurements. We report a case of sporadic cardiac rhabdomyoma in a neonate treated with everolimus resulting in tumor regression as documented by cardiac MRI. While on everolimus, our patient had an increased incidence of a preexisting arrhythmia, which resolved with planned cessation of therapy, suggesting that close monitoring is imperative in patients with arrhythmia.
Journalism as a synergistic object
Authors: Butyrina M.
Published: May 2019

The study highlights the latest mass-media trends and constructs in the context of the synergetic paradigm. Journalism is described as an open, non-linear, unbalanced, dynamic system which is capable of self-organization. The components of the synergetic cycle of the presented system are identified. Its actual phase of development is defined as post-journalism. The most typical phenomena with fractal features are determined. They include participative and amateur journalism. Manifestations of the holistic principle in the functioning of the system are also traced at the level of individual factors of the communication system - sender, recipient, message and code. Powerful influence of fluctuations of the external for journalism systems is outlined.

Media picture of the world, which integrates not only information, but also pseudo-information elements that are also part of the functional field of journalistic influence, is defined as a systematic result of the «work» of the given system. The author outlines the transformation of the two-stage communication model, the complementation of the communication system with such factors as «bubble filter» and «content aggregators», expansion of the functional and role position of the sender.It is stated that the increase in the level of entropy in the journalism system is due to the non-compliance with professional standards, ethical norms, and accepted functional roles from the fractal phenomena that are currently only beginning to be formed within the system. From the standpoint of synergetics, the phenomenon of mediatization, which is the result of self-organization of the journalism system in interaction with the actors of the environment, is disclosed.Methodological features of the synergetic approach to the study of journalism are also revealed. They include metaphorization of the synergetic terminology; discreteness in the application of the synergetic paradigm, which foresees emphasis on some regularities in the development of the system while levelling the others; implementation of the synergetic approach in a simplified version through the analysis of the objects as a set of the system features.
Ukrainian military press: correspondence to lifetime
Authors: Pidmohylna N. , Nauruzov A.
Published: May 2019

Since 2014, materials and publications have become extremely popular in Ukraine, the content of which is connected with the armed conflict in the east of Ukraine. According to the results of sociological polls in 2018 – respondents named the conflict in the Donbas and Luhansk region the main problem of modern Ukraine. It’s not the first time when the history of the development of military journalism and the military media have attracted the attention of scientists, but it is still early to consider all issues relating to military buildings, in particular those that appeared during the armed conflict in the east of Ukraine. The purpose of the article is to characterize the content and image features of the public and private military media of Ukraine. To achieve this goal, it is supposed to analyze the most replicated and influential modern military media of Ukraine, as well as to consider the newly created edition of military subjects of the ATO / EP period and compare the features of their content during the information war.The object of the study: the central print edition of the Ministry of Defense of Ukraine “People’s Army” and the newspaper of the special purpose regiment of the National Guard of Ukraine “Azov” “Black Sun”. Comparing the two editions, we have come to the conclusion that both newspapers, first of all, are striving to widely and objectively cover the current problems of the Ukrainian army, its reform issues, talk about current events in the ATO / OOS zone, and also – and most importantly – take care of the formation of the reader’s audience of a positive image for the fatherland shield.The newspapers mentioned above have various circulations, different form their own content, different in lexical features, but adequately fulfill their main purpose: to provide the citizens of Ukraine with the information about the life of the modern army, which meets the requirements of the time.
Use of sweeteners in osmotic pretreatment before freeze-drying of pear and pineapple
Authors: Włodarczyk-Stasiak M. , Mazurek A. , Jamroz J. , Pankiewicz U. , Kowalski R.
Published: May 2019

The aim of the study was to analyse the influence of the type of osmotic substance (sucrose, glucose, xylitol, trehalose, and sorbitol) on the physicochemical properties of freeze-dried fruit (pear and pineapple). Controlling the functional properties of freeze-dried fruit after osmotic dehydration with aqueous solutions at water activity of aw=0.90 is presented. Decrease in the water adsorption index (WAI) was recorded for all dehydrated samples. The largest decrease (for pears and pineapples by 25 and 65%, respectively) was observed in osmoactive solutions containing trehalose. Considerable increase in the FAI was recorded in samples of dehydrated pineapple. In osmoactive trehalose solutions that increase hardly reached 46%, whereas in sorbitol and xylitol its value elevated to 39% and 13%, respectively. Regardless of the osmoactive sweetener applied prior to freeze-drying, an increase in specific surface area (SBET) of dried materials was observed. For dehydrated pears, SBET ranged from 96 to 697 m2 g−1, and for pineapple, from 115 to 938 m2 g−1. Osmotic dehydration before lyophilisation of fruit samples weakened rehydration relative to the control. The dehydration carried out with osmoactive sweeteners, that is, sorbitol, xylitol, and trehalose, allows obtaining a product with good functional properties that can be successfully used for supplementation of dietary products, in particular for diabetics.
Corn starch nanoparticles: Preparation, characterization, and utilization as a fat replacer in salad dressing
Authors: Kaur J. , Kaur G. , Sharma S.
Published: May 2019

Corn starch nanoparticles (SNPs) were prepared by ultrasonication of starch for 40 min at an amplitude of 40%, which modified some properties of starch so that it could be used as a functional ingredient in food products. The cereal SNPs were characterized on the basis of their morphology, particle size, crystallinity, pasting and functional properties. The SNPs were globular in shape as revealed by TEM. There was a decrease in the crystallanity of SNPs, whereas the functional properties were enhanced in SNPs as compared to raw starch. SNPs had a less paste viscosity as compared to raw starch. Salad dressing was prepared by using SNPs as a fat replacer. The prepared salad dressing was examined for colour, viscosity, and sensory attributes. Overall 60% of fat was replaced using corn SNPs without compromising its quality characteristics.
Magnetic Order in Heisenberg Models on Non-Bravais Lattice: Popov-Fedotov Functional Method
Authors: Nga Pham Thi Thanh , Thang Nguyen Toan
Published: May 2019

We study magnetic properties of ordered phase in Heisenberg model on a non-Bravais lattice by means of Popov - Fedotov trick, which takes into account a rigorous constraint of a single occupancy. We derive magnetization and free energy using sadle point approximation in the functional integral formalism. We illustrate the application of the Popov -- Fedotov approach to the Heisenberg antiferromagnet on a honeycomb lattice.
Constraints on the \(SU(3)_C \otimes SU(2)_L \otimes SU(3)_R \otimes U(1)_X\) Model from the Process \(W_2 \rightarrow t \bar{b}\)
Authors: Huong Do Thi , Thao Nguyen Huy
Published: May 2019

We study the process \(pp \rightarrow W_2 \rightarrow t \bar{b}\) in the \(SU(3)_C \otimes SU(2)_L \otimes SU(3)_R \otimes U(1)_X\) model. The production cross-section times branching ratio is determined. We use the LHC data to derive constraint on the new physical scale, \(m_{W_2}\), and the elements of right-handed quarks mixing matrix.
Sampling the Folding Transition State Ensemble in a Tube-like Model of Protein
Authors: Hung Nguyen Ba , Hoang Trinh Xuan
Published: May 2019

We used the tube model with Go-like potential for native contacts to study the folding transition of a designed three-helix bundle and a designed protein G-like structure. It is shown that both proteins in this model are two-state folders with a cooperative folding transition coincided with the collapse transition. We defined the transition states as protein conformations in a small region around the saddle point on a free energy surface with the energy and the conformationalroot mean square deviation (rmsd) from the native state as the coordinates. The transition state region on the free energy surface then was sampled by using umbrella sampling technique. We show that the transition state ensemble is broad consisting of different conformations that have different folded and unfolded elements.
Has the evidence for moral licensing been inflated by publication bias?
Authors: Kuper Niclas , Bott Antonia
Published: May 2019

Moral licensing describes the phenomenon that displaying moral behavior can lead to subsequent immoral behavior. This is usually explained by the idea that an initial moral act affirms the moral self-image and hence licenses subsequent immoral acts. Previous meta-analyses on moral licensing indicate significant overall effects of d> .30. However, several large replication studies have either not found the effect or reported a substantially smaller effect size. The present article investigated whether this can be attributed to publication bias. Datasets from two previous meta-analyses on moral licensing were compared and when necessary modified. The larger dataset was used for the present analyses. Using PET-PEESE and a three-parameter-selection-model (3-PSM), we found some evidence for publication bias. The adjusted effect sizes were reduced to d= -0.05, p= .64 and d= 0.18, p= .002, respectively. While the first estimate could be an underestimation, we also found indications that the second estimate might exaggerate the true effect size. It is concluded that both the evidence for and the size of moral licensing effects has likely been inflated by publication bias. Furthermore, our findings indicate that culture moderates the moral licensing effect. Recommendations for future meta-analytic and empirical work are given. Subsequent studies on moral licensing should be adequately powered and ideally pre-registered.
EFFECT OF SOCIAL ENVIRONMENT AND PERSONALITY TRAITS ON ENTREPRENEURSHIP TENDENCIES OF STUDENTS: AN APPLICATION IN FOUNDATION UNIVERSITY
Authors: SELÇUK Hamide , BURAK Emel
Published: May 2019

The aim of this study, which is an exploratory research, is to determine the effects of social environment and personality traits of university students on entrepreneurship tendencies. The universe of the research is comprised of all university students. The sample of the study consists of students enrolled at a foundation university. A questionnaire including the questions about the social environment and personality traits of university students and their entrepreneurship tendencies are applied.  The data, collected by 130 questionnaires with complete and sufficient content, were analyzed and interpreted. As a result of the analysis, it has been seen that there is a positive relationship between risk taking propensity, the need for achievement, innovativeness and the entrepreneurship tendency.
DÖVİZ KURU RİSKİNİN BORSA İSTANBUL 100 ENDEKSİ ÜZERİNDEKİ ETKİSİ ZAMAN SERİSİ ANALİZİ: TÜRKİYE ÖRNEĞİ
Authors: DİLBAZ ALACAHAN Nur , AKARSU Yağmur
Published: May 2019

Piyasaları üzerinde önemli etkiye sahip olan döviz kurları özellikle gelişmekte olan ülkeler açısından çok önemlidir. Mali piyasalarda meydana gelen değişmeler ve gelişmeler gerek bireysel gerekse firma bazında yatırım yapmak isteyenleri etkilemektedir.Bu çalışmanın amacı, Türkiye’de döviz kurunun BIST 100 endeksi üzerinde etkisi olup olmadığını araştırmaktır.Bu amaçla, aylık olarak kullanılan veri seti 2004 Ocak ayından başlamak üzere – 2018 Haziran ayına kadar her bir veri seti için 174 gözlem kullanılmıştır.Modelin spesifikasyonunda Bağımlı değişken Borsa İstanbul 100 Endeksi Kapanış Aylık ortalama değerleri olarak belirlenmiştir.Bağımsız değişken Türk Lirası üzerinden dolar başına aylık ortalama değer olmak üzere Amerikan Doları döviz kuru kabul edilerek düzenlenmiş ve regres edilmiştir.Export ön raporlama sonuçlarına göre, döviz kuru ve Bist 100 ilişkisi ele alınırken zaman serisi analizlerinde dolar kurunun 2.dereceden gecikmeli değerlerinin ve hata paylarının Bist 100 indeksi değişimleri üzerinde gecikmeli etkisi bulunmaktadır.Analiz sonuçlarına göre, dolar kurunun gecikmeli değerleri ile Bist 100 endeksi arasında anlamlı bir ilişki vardır.
Anti-PD-1 Immunotherapy-Induced Flare of a Known Underlying Relapsing Vasculitis Mimicking Recurrent Cancer
Authors: Nabel Christopher S. , Severgnini Mariano , Hung Yin P. , Cunningham-Bussel Amy , Gjini Evisa , Kleinsteuber Katja , Seymour Lake J. , Holland Martha K. , Cunningham Rachel , Felt Kristin D. , Vivero Marina , Rodig Scott J. , Massarotti Elena M. , Rahma Osama E. , Harshman Lauren C.
Published: May 2019

Safe use of immune checkpoint blockade in patients with cancer and autoimmune disorders requires a better understanding of the pathophysiology of immunologic activation. We describe the immune correlates of reactivation of granulomatosis with polyangiitis (GPA)—an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis—in a patient with metastatic urothelial carcinoma treated with pembrolizumab. After PD-1 blockade, an inflammatory pulmonary nodule demonstrated a granulomatous, CD4+ T-cell infiltrate, correlating with increased CD4+ and CD8+ naïve memory cells in the peripheral blood without changes in other immune checkpoint receptors. Placed within the context of the existing literature on GPA and disease control, our findings suggest a key role for PD-1 in GPA self-tolerance and that selective strategies for immunotherapy may be needed in patients with certain autoimmune disorders. We further summarize the current literature regarding reactivation of autoimmune disorders in patients undergoing immune checkpoint blockade, as well as potential immunosuppressive strategies to minimize the risks of further vasculitic reactivation upon rechallenge with anti-PD-1 blockade.

Key Points

Nonspecific imaging findings in patients with cancer and rheumatological disorders may require biopsy to distinguish underlying pathology. Patients with rheumatologic disorders have increased risk of reactivation with PD-(L)1 immune checkpoint blockade, requiring assessment of disease status before starting treatment. Further study is needed to evaluate the efficacy of treatment regimens in preventing and controlling disease reactivation.