bluuebunny/crossref_metadata_2025 huggingface dataset:
Sodium picosulfate in the clinical practice of a surgeon
Authors: Matveev I. A. , Lipovoy S. V. , Kozlov M. P. , Povarnin N. N.
Published: November 2023

Picosulfate, a diphenylmethane derivative, belongs to a group of drugs called stimulant laxatives. It is widely used in surgery to treat various colon evacuation disorders due to its effectiveness, safety of use and ease of dosage selection, as well as the option to combine with other laxatives. It is administered much more frequently for colorectal cancer screening, when the colon is prepared using sodium picosulfate combined with other osmotic laxatives, most often polyethylene glycol, which allows to use smaller volumes of solution. According to the literature, this method for cleaning the colon is used most often, which is associated with better adherence of patients to the intake of small volumes of liquid, as shown by our observations. The article highlights the literature data, and the authors also present their own experience – a clinical case report of the treatment of a 30-year-old patient diagnosed with grade I external and internal hemorrhoids. Laser ablation of internal and excision of external hemorrhoids was performed under local anesthesia. Regulax® Picosulfate was included in the therapy in the postoperative period, along with topical and pain relief drugs. As a result, the patient had a comfortable, not very painful bowel movement on the following day after the surgery. The laxative was used to manage stool for a week. In conclusion, the authors draw attention to the fact that increased patient compliance in preparing the colon for examination leads to better cleaning and more informative results during colonoscopy. Therefore, Regulax® Picosulfate combined with other laxatives to prepare a patient for examination, in particular colorectal cancer screening, where it is used most often, applies to a huge number of patients, so the problem of further study of its use is socially significant.
The effect of transdermal combined product on the state of microcirculatory blood flow in patients with chronic venous insufficiency
Authors: Burov Yu. А. , Mikulskaya E. G. , Nesnova E. S.
Published: November 2023

Introduction. Treatment of patients with severe chronic venous insufficiency of the lower extremities is complex and along with compression therapy includes transdural use of drugs. Aim. To study the microcirculatory blood flow of the tissues of the distal segments of the lower limbs in patients with severe chronic venous insufficiency and the possibility of its correction with the use of a combined product for local application.Materials and мethods. The study included 40 patients suffering from varicose vein disease with chronic venous insufficiency of C3-C5 stages according to CEAP. In the main group of patients (n = 30) the transdermal combined product Detragel® was used; patients of the comparison group (n = 10) received only basic compression therapy of functional class II. The basis for the assessment of microcirculation of the lower limbs soft tissues was the analysis of the results of laser doppler flowmetry. Results. At local use of Detragel® in combination with elastic bandage in 91% of observations, there was a statically significant decrease of basal blood flow less than 4.0 pf. units (p < 0.05). The mean basal blood flow was 2.7 ± 0.6 pf. units (1.6–3.9 pf. units, 95% CI), which was consistent with normal values. Statistically significant decrease in veno-arteriolar response to 51.5 ± 10.8% (36.0–68.8%, 95% CI) was recorded in 75% of cases after 14 days of topical treatment, although veno-arteriolar response decreased to normal in only 53% of cases. Conclusion. Correction of microcirculatory disorders in patients with varicose vein disease should include local use of medicine.
Local personalised treatment of long-term non-healing wounds
Authors: Glukhov A. A. , Andreev A. A. , Aralova M. V. , Ostroushko A. P. , Laptiyova A. Yu.
Published: November 2023

Introduction. A significant number of nosologies can result in long-term non-healing wounds that mostly have similar principles of local treatment. However, positive clinical outcomes are not always obtained in the management of such wounds. The authors have developed a personalized technology for local treatment of chronic wounds depending on their etiology. Aim. Was to investigate the effectiveness of the proposed methods and personalized approaches for local treatment of long-term nonhealing wounds. Materials and methods. Innovative methods of cleaning and stimulating regeneration of non-healing wounds have been developed in the study; their effectiveness was tested in 3 blocks of the study. The first block of the study included patients with long-term non-healing wounds of venous etiology, the second and third blocks included patients with long-term non-healing arterial and neurotrophic wounds, respectively. Each block involved two series of tests studying the developed methods of cryodestruction and stimulation of regeneration, respectively. In the 1st block, the 3rd series of tests was additionally conducted; it included patients with wounds larger than 20 cm2 in size. Results. The developed methods of cryodestruction accelerate the course of phase I of the wound process by 12% in patients with longterm non-healing wounds of venous etiology, by 27% in patients with critical ischemia of the lower extremities, by 70% in patients with neurotrophic etiology (p ≥ 0.05). The use of the proposed methods of stimulating regeneration significantly reduced the average area of wounds in the study blocks. The main components of treatment stimulating regeneration in long-term non-healing wounds have been identified considering wound etiology. Conclusion. The use of the developed algorithm for local personalized treatment of long-term non-healing wounds considering underlying disorders contributes to an earlier cleaning of the wound surface, elimination of inflammation and an increased activity of regeneration processes when compared with conventional approaches.
Inpatient substitution approaches to medical care and their impact on the dynamics of the prevalence of varicose veins
Authors: Potapov M. P.
Published: November 2023

Introduction. The conducted epidemiological studies show a significant socio-economic burden borne by modern society due to the high prevalence of varicose veins of the lower extremities among the able-bodied population of developed countries. Aim. Assessment ofthe influence ofthe factor of widespread use of minimally invasive inpatient replacement technologies on the prevalence of varicose veins of the lower extremities in a large region of the Central Federal District of the Russian Federation under the conditions of transformation of approaches to the treatment of varicose veins of the lower extremities. Materials and methods. A retrospective study was conducted for 2011–2021 of statistical indicators of the work of medical organizations of the Yaroslavl region, namely: the total number of attached adult population, the dynamics of the number of attached population, the total number and dynamics of the number of patients with an established diagnosis of varicose veins of the lower extremities. Results and discussion. The total population weight of the sample in the Yaroslavl region for all periods of the study was 11 406 181 people. The fixed weighted average value of the prevalence of varicose veins of the lower extremities at the end of the year in the Yaroslavl region in the period 2011–2021, according to medical organizations providing medical care on a territorial-precinct basis, was 0.784% (CI: 0.779–0.789). At the same time, in 2011–2012 and 2018–2019, the frequency of varicose veins of the lower extremities event was higher than the average value, in 2013–2016 and 2020–2021. Conclusion. It has been established that over the past decade there has been an annual decrease in the prevalence of varicose veins of the lower extremities in the region. At the same time, there was an increase in the share of medical care provided to patients by non-governmental medical organizations. The latter in their activities are focused on hospital-substituting technologies in the treatment of this disease.
Experiência dos Usuários da Estratégia Saúde da Família Acerca da Terapia Comunitária Integrativa
Authors: Ferraz Ivana Santos , Martins Filho Ismar Eduardo
Published: November 2023

Descrever a experiência dos usuários da Estratégia Saúde da Família acerca da Terapia Comunitária Integrativa. Este estudo é de abordagem qualitativa. A pesquisa formou-se com 14 participantes e foram eleitos como integrantes deste estudo usuários que participavam ativamente da referida terapia. O local escolhido para este estudo foi o município de Jequié, situado na Bahia. O percurso da análise dos dados foi orientado pelo diário de campo e pela Análise Temática de Conteúdo de Bardin. A partir da análise surgiram cinco categorias: a percepção dos usuários acerca da Terapia Comunitária Integrativa; a Terapia Comunitária Integrativa como tecnologia social leve para a promoção da saúde e bem-estar social; a Terapia Comunitária Integrativa como melhoria do estilo de vida; a Terapia Comunitária Integrativa como novo recurso da prática do cuidado; e a Terapia Comunitária Integrativa: uma estratégia de intervenção em saúde mental. Desta forma, afirmamos que a Terapia Comunitária Integrativa como espaço de escuta é um dispositivo valioso para potencializar a socialização, a solidariedade e a humanização entre os trabalhadores de saúde e os usuários da Estratégia Saúde da Família, confirmando assim a argumentação central investigada nesta pesquisa.
Capitais e ativos presentes em unidades familiares: Uma análise em assentamentos rurais de Palmeira das Missões (RS)
Authors: Spanevello Rosani Marisa , Martins Sinara Pizzi , Camara Simone Bueno , Lago Adriano
Published: November 2023

O objetivo deste artigo consiste em analisar quais são os ativos disponíveis e como esses são utilizados pelas famílias que compõem os assentamentos rurais no município de Palmeira das Missões (RS). Utiliza-se a abordagem teórico-metodológica da diversificação dos meios de vida (livelihoods) de Frank Ellis para embasamento teórico e posterior análise de dados. A pesquisa de campo envolveu 33 famílias residentes nos assentamentos Potreiro Bonito, Terra Nova e Nova Vida, no período de janeiro a março de 2020. A metodologia empregada consistiu na estatística descritiva e na análise de conteúdo. Com base nesse contexto, os principais resultados denotam a existência dos cinco tipos de capitais abordados por Frank Ellis nos assentamentos. No entanto, os capitais sociais são balizados pela participação em cooperativas, sindicatos rurais e organizações religiosas. Também há baixa presença de capitais físicos e financeiros. Com relação às produções, os assentamentos Terra Nova e Potreiro Bonito têm alta intensidade na pecuária de leite, enquanto o Nova Vida tem na agricultura. Neles todos, em maior ou menor grau, também são realizadas produções de autoconsumo e combinações de atividades não agrícolas e/ou fora da unidade familiar. Os assentamentos estudados apresentam ainda baixa geração de renda agrícola, indicando a necessidade de ações que permitam que os agricultores desenvolvam ou adquiram os capitais necessários para sua reprodução socioeconômica.
Conjuntura econômica baseada no agronegócio e os Objetivos do Desenvolvimento Sustentável (ODS): Uma avaliação do município de Rondonópolis, Mato Grosso
Authors: Macedo Luís Otávio Bau , Santos Wingert Gustavo , Martins Barbosa Adonnay
Published: November 2023

O trabalho tem por objetivo confrontar o crescimento econômico do município de Rondonópolis, Mato Grosso, e o seu desenvolvimento sustentável. Utilizou-se como ferramenta metodológica o relatório IDSC-BR por meio da análise desenvolvida pelas dimensões Pessoas, Planeta, Prosperidade, Paz e Parcerias. Adicionalmente, realizou-se a análise de Cluster de municípios com população ente 200 a 250 mil habitantes, cujo grupo de Rondonópolis ficou composto por Novo Hamburgo/RS, Colombo/PR, Dourados/MS, Águas Lindas de Goiás/GO, Santa Luzia/MG, Passo Fundo/RS, Itapevi/SP e Lauro de Freitas/BA. Identificou-se que os ODS que apresentaram resultados preocupantes foram auferidos no (i) combate à fome, pobreza, e criminalidade, (ii) na oferta de saúde e educação de boa qualidade, (iii) na promoção da igualdade de gênero, (iv) na proteção da vida terrestre e (v) na consolidação de parcerias que facilitem a implementação dos ODS. O trabalho concluiu que o município de Rondonópolis se destaca nos objetivos de “Cidades e Comunidades Sustentáveis” e “Energias Renováveis e Acessíveis”, onde atinge pontuações elevadas. Contudo, enfrenta desafios para a redução da desigualdade de renda, pobreza, criminalidade e de enfrentamento às mudanças climáticas que são relacionadas ao seu modelo econômico de desenvolvimento, caracterizado pela produção e processamento da agropecuária de larga escala, vinculados ao agronegócio.
Hiper- Estetik: Çoklu Donanımların Dönüştürücü Ekseninde Sanat Algısı
Authors: Eryılmaz Ece Büşra , Eker Metin
Published: November 2023

Çağdaş sanat ve çağdaş estetik genellemesine tek bir estetik kapsam ya da tür ile karşılık vermenin mümkün olmadığı günümüzde, “hiper-estetik” üzerinde durulması gereken bir içerik ile dikkat çekmektedir. Teknolojik ve tekno kültürel kapsamlar, doğrudan olmasa da dolaylı ve çeşitli estetik türleri gündeme getirmekte ve daha dağınık olarak sunmaktadır. Söz konusu dağınıklığı toparlama ve estetik temayülleri belirli bir kapsam çatısı altında kavuşturma gereği açısından hiper-estetik ve yeni sanat algısı üzerinde tartışılması gereken bir değerlendirme doğrultusunu karşımıza çıkarmaktadır.
Sürdürülebilirlik ve Grafik Tasarım: Ekolojik Ambalaj Tasarımlarının Görsel Analizi
Authors: İri Öztürk Ayşe
Published: November 2023

Küresel değişim altında bozulmaya meydan okuyan ekolojik adımlar, ekosistemin işlevini anlamak, biyolojik çeşitliliği korumak için etkili yönetim stratejileridir. Bu stratejilerden biri de sürdürülebilir üretim ve tüketim modellerinin endüstride yer almasıdır. Küreselleşmenin giderek yaygınlaştığı bir dünyada ambalaj endüstrisi, ürünlerin üreticiden tüketiciye küresel düzeyde taşınmasına ve ticarileştirilmesine olanak sağlamaktadır. Ambalaj tasarımı, ürünü korumak, taşımayı kolaylaştırmak, tüketiciye bilgi sağlamak ve ürünü rafta farklılaştırmaktadır. Ayrıca ambalaj tasarımı, görsel bir iletişim olarak markanın sürdürülebilirlik hedeflerini de yansıtmalıdır. Bu sebeple, ambalaj endüstrisinin, uluslararası kuruluşlar tarafından belirlenen sürdürülebilirlik hedefleri ile uyum sağlarken, her geçen gün büyüyen pazar taleplerine nasıl uyum sağladığını incelemek gerekmektedir. Çalışmanın amacı, ambalaj üreticilerinin eko-tasarım ve sürdürülebilirlik temasını görsel iletişim bağlamında nasıl ele aldıklarını incelemektir. Bu çalışmada sürdürülebilirlikle tasarım arasındaki ilişki açıklanmaya çalışılmaktadır. Aynı zamanda bu araştırmada eko-tasarımlı ürün ambalajlarının görsel olarak incelenmesi için nitel araştırma yöntemlerinden biri olan betimsel analiz yöntemi kullanılmıştır.
Ethanolic extract of Aloe arborescens stimulates neonatal rat calvarial cells proliferation, migration and osteogenic differentiation
Authors: Blanco Nicolás Olegario , Gili Valeria , Laiuppa Juan Andrés , Santillán Graciela Edith
Published: November 2023

The medicinal plant Aloe arborescens Miller has chemical compounds that could stimulate the activity of bone-forming cells, but no studies have been found in this regard. We evaluated the effects of different dilutions of aqueous (1/10; 1/100; 1/1000) or ethanolic (1/1000; 1/2000; 1/5000) extracts of parenchyma from A. arborescens on the viability, proliferation, migration and osteogenic differentiation of primary cell cultures from neonatal rat calvaria. In none of the conditions studied did cell viability decrease (p ≤ 0.01). Furthermore, the 1/5000 ethanolic extract dilution showed a positive effect on cell viability at 48 h and 72 h and the latter was correlated with a 27 % (p ≤ 0.01) increase in cell proliferation. Ethanolic extract significantly stimulated cell migration and cultured mineralization with respect to control, showing the maximal effect at a dilution 1/5000. Together, the results show that the A. arborescens extracts do not have toxic effects. In addition, ethanolic extract stimulates proliferation, migration and osteogenic differentiation of rat calvarial cells, suggesting a potential bone anabolic action.
Seasonal differences in water quality of highland lakes and its influencing factors: A case study of Dianchi Lake
Authors: Liu Chenyang , Zhang Zhuoya , Li Jiaxi , Ge Hailong , Xing Yajiao
Published: November 2023

Water quality is of great significance to human survival and development. It is of good theoretical value to study seasonal water quality variation and driving factors in plateau lakes. This paper studied the variation of water quality parameters in different seasons and their relationship with land use and climate factors in Dianchi Lake, Yunnan Province from 2001 to 2019. The results show that the factors restricting water environment in different seasons are different, but basically close. The water quality parameters of multiple water quality monitoring stations in different seasons showed a decreasing or insignificant trend. In the rainy season, the temperature and precipitation were positively correlated with most water quality parameters, while the driving effect of climate factors was not significant in the dry season. Different land types have different effects on water quality indexes in different seasons. The water quality score was higher in the rainy season than in the dry season. The scores of water quality stations in the south and middle of Dianchi Lake are higher than those in the north. In this study, the relationship between climate, land, and water quality is established, which provides a way for the research of water quality parameters.
Espaços discursivos como possibilidade de formação humana e inclusão
Authors: Silva Nazareth Vidal da , Hernandez-Piloto Sumika Soares de Freitas , De Almeida Gabriela Melo Santana , Almeida Mariangela Lima de
Published: November 2023

Based on the concepts of Jürgen Habermas's Theory of Communicative Action, the Discursive Spaces make it possible, by democratic means, to debate training, management and school inclusion within the collaborative networks established between the university, municipal and state education networks and higher education institutions in Portuguese-speaking countries, through research and extension projects. The purpose is to understand the discursive space as a space for participation between subjects that, through discourse, present arguments to build consensus and strengthen mutual understanding, in order to capture the movements experienced by researchers and participants in research processes carried out through action research; and also to encourage the development of collaborative formation spaces in defense of human formation from the perspective of inclusion. We chose to use qualitative collaborative-critical action research to understand how Discursive Spaces have been configured in the context of the research group. In this initial research process, we took the participants arguments in the moments of constitution of the understanding of Discursive Spaces, in the planning and realization of them. Two municipal education networks took part, involving (municipal) managers, students and teachers (graduate and postgraduate), with training, public policies, management and action research being the themes. It is an urgent challenge to deepen our understanding of these processes and an enormous challenge to establish a culture of sustainability of life, in other words, to promote a re-reading of the world in which life in all its relationships and contradictions is central.
A produção da desinformação na esfera pública
Authors: Gerlin Meri Nadia Marques , Sousa Rodrigo Silva Caxias de , Pastl Carla Monego Lins
Published: November 2023

It discusses the relevance of how the use of the concepts of banal evil and radical evil are outlined as potential analytical references to understand the processes of disinformation that circulate in the public sphere, especially on social media platforms, as a way of fostering a problematization that defends that these manifestations are based both on the interpretative pauperization of subjects and communities, and on hatred reproduced in an instrumental way, perpetuated due to political, economic and religious interests. Thus, the present study presents aspects related to the notions of radical evil (Kant) and its rearticulation in Arendt's work (banal evil and radical evil), relateding them with the concepts of disinformation, the public sphere and the world of life as a form of theorizing how misinformation makes it impossible to expand interlocutionary acts and intersubjective understanding within the scope of politics.
Kisspeptin and its Current Clinical Status-A Systematic Review
Authors: Velmurugan Hemasri , Mannava Anjali Srikanth , Thangaraju Pugazhenthan , Neelambaran Krishnapriya
Published: November 2023

Background:

Kisspeptin was initially known as metastin for its role in suppressing
metastasis in melanoma and breast cancer. Later, based on its ability to stimulate
GPR54, its importance in maintaining an intact hypothalamic-pituitary-ovarian axis
was recognised, which is the basis for the widespread application of the drug in several
conditions such as secondary amenorrhea, regulation of puberty onset, ovarian function,
trophoblast invasion, fertility regulation, parturition, and lactation. This systematic study
aims to evaluate the current status of kisspentin in clinical trials.

Methods:

The keywords 'kisspeptin' or 'metastin' were used in the clinicaltrials.gov website
and Clinical Trial Registry of India (CTRI) to find eligible clinical trials or records
carried out without time constraints until February 26, 2023.

Results:

A total of 33 records were identified through clinical trial databases. All records
were screened, and four trials were rejected as they failed to meet the inclusion criteria.
Finally, 29 (87.9%) reports of interventional clinical trials with kisspeptin were reviewed.

Conclusion:

Kisspeptin can be viewed as a multipurpose drug with considerably fewer
side effects due to its effects simulating normal physiological processes in our body.
Recent Progress in the Hesperetin Delivery Regimes: Significance of Pleiotropic
Actions and Synergistic Anticancer Efficacy
Authors: Malik Parth , Bernela Manju , Seth Mahima , Kaushal Priya , Mukherjee Tapan Kumar
Published: November 2023

Background:

In the plant kingdom, flavonoids are widely distributed with multifunctional immunomodulatory
actions. Hesperetin (HST) remains one of the well-studied compounds in this domain, initially
perceived in citrus plants as an aglycone derivative of hesperidin (HDN).

Observations:

Natural origin, low in vivo toxicity, and pleiotropic functional essence are the foremost fascinations
for HST use as an anticancer drug. However, low aqueous solubility accompanied with a prompt degradation
by intestinal and hepatocellular enzymes impairs HST physiological absorption

Motivation:

Remedies attempted herein comprise the synthesis of derivatives and nanocarrier (NC)-mediated
delivery. As the derivative synthesis aggravates the structural complexity, NC-driven HST delivery has
emerged as a sustainable approach for its sustained release. Recent interest in HST has been due to its significant
anticancer potential, characterized via inhibited cell division (proliferation), new blood vessel formation
(angiogenesis), forceful occupation of neighboring cell’s space (invasion), migration to erstwhile physiological
locations (metastasis) and apoptotic induction. The sensitization of chemotherapeutic drugs (CDs) by HST
is driven via stoichiometrically regulated synergistic actions.

Purpose and Conclusion:

This article sheds light on HST structure-function correlation and pleiotropic anticancer
mechanisms, in unaided and NC-administered delivery in singular and with CDs synergy. The discussion
could streamline the HST usefulness and long-term anticancer efficacy.
Effectiveness of Chinese Herbal Medicine in Postoperative Fatigue
Syndrome Following Total Joint Arthroplasty or Hip Fracture Surgery:
Evidence from Randomized Controlled Trials
Authors: Zhao Jinlong , Zhou Guanghui , Wang Zhongsheng , Liang Guihong , Wei Xingde , Sha Bangxin , Yang Weiyi , Liu Jun , Chen Hongyun
Published: November 2023

Background::

There is no high-quality, evidence-based protocol for the treatment of
postoperative fatigue syndrome (POFS) after total joint arthroplasty (TJA) or fracture surgery with
Chinese herbal medicine (CHM).

Purpose::

The purpose of this study was to explore the efficacy of CHM in the treatment of POFS
after TJA or hip fracture surgery (HFS).

Methods::

We searched six databases to obtain randomized controlled trials (RCTs) of CHM for
the treatment of POFS after TJA or HFS. The retrieval time limit was from the establishment of
each database to August, 2022. According to the Cochrane Handbook for Systematic Reviews
version 5.1, we used RevMan 5.3 to evaluate the quality of the studies. Stata 14.0 software was
used to merge and analyze the data. The weighted mean difference (WMD) was the effect estimate
for statistical analysis. We also performed subgroup analyses according to different types of surgeries.

Results::

A total of 11 RCTs were included in this study, comprising 430 cases in the CHM group
and 432 cases in the control group (CG). The meta-analysis results showed that there was no significant
difference in the Brief Profile of Mood States (BPOMS) score (WMD=0.08, 95% confidence
interval (CI): -0.29 to 0.45, P=0.688), Christensen Fatigue scale (CHFS) score (WMD =
0.15, 95% CI: -0.09 to 0.39, P=0.214) or Identity-Consequence Fatigue Scale (ICFS) score
(WMD=-0.40, 95% CI: -1.84 to 1.05, P=0.589) between the CHM group and the CG on the first
postoperative day. The use of CHM significantly reduced the BPOMS score (WMD=-0.85 and
WMD=-3.01, respectively), CHFS score (WMD=-1.01 and WMD= -1.45, respectively), and ICFS
score (WMD=-3.51 and WMD=-5.26) on postoperative days 3 and 7. Compared with the CG, the
CHM group had significantly increased serum transferrin and IgG levels on postoperative days 3
and 7. The subgroup analysis results suggested that the application of CHM in HFS patients improved
fatigue symptoms on postoperative days 3 and 7, while the application of CHM to treat
POFS in TJA patients had great inconsistency in the evaluation of different indicators.

Conclusion::

The application of CHM improved the fatigue status of POFS patients after TJA or
HFS and increased the levels of transferrin and IgG in serum, which is conducive to promoting the
postoperative rehabilitation process of patients. The subgroup analysis results showed that the application
of CHM to intervene in POFS in HFS patients had obvious benefits.
Bioactive Exploration in Functional Foods: Unlocking Nature's Treasures
Authors: Mittal Ravi K. , Mishra Raghav , Sharma Vikram , Purohit Priyank
Published: November 2023

Background::

Functional foods offer an appealing way to improve health and prevent
chronic diseases, and this subject has received much attention lately. They are effective in preventing
chronic diseases like cancer, diabetes, heart disease, and obesity, according to research.

Objective::

This work presents an in-depth analysis of functional foods, covering key challenges
from a scientific, legal, and commercial perspective.

Methods::

Multiple databases were searched to find studies on functional foods included in the
systematic literature review. Various aspects of functional foods, from their classification, impact
on human wellness, effectiveness in inhibiting chronic diseases, the regulatory environment,
global market trends, and industry challenges, are all clarified in this thorough review.

Results::

This study aims to enhance understanding and establish a pathway for functional foods
to be acknowledged as valid choices in the field of dietary supplements. It provides a thorough
investigation of bioactive compounds present in functional foods, including but not limited to
polyphenols, carotenoids, omega fatty acids, prebiotics, probiotics, and dietary fiber, along with
an overview of their potential to mitigate chronic illnesses. We engage in an in-depth exploration
of regulatory frameworks, shed light on groundbreaking research advancements, and meticulously
examine strategies for commercialization and the variety of global challenges that accompany
them. Establishing scientific consensus, navigating complex regulatory processes, dealing with
skeptical consumers, and rising levels of competition are all problems that need to be solved in
this field.

Conclusion::

The field of functional foods can advance further, promoting better public health
outcomes, by deeply comprehending and addressing these complex dimensions.
Beta-blockers in Hypertensive Left Ventricular Hypertrophy and Atrial
Fibrillation Prevention
Authors: Koraćević Goran , Mićić Sladjana , Stojanović Milovan , Zdravkovic Marija , Simić Dragan , Kostić Tomislav , Atanasković Vesna , Janković-Tomašević Ružica
Published: November 2023

Background:

Hypertensive left ventricular hypertrophy (HTN LVH) is a key risk factor
for atrial fibrillation (AF).

Objective:

To evaluate the possible role of beta-blockers (BBs) in addition to a renin-angiotensinaldosterone
system (RAAS) blocker in AF prevention in patients with HTN LVH.

Methods:

We performed a PubMed, Elsevier, SAGE, Oxford, and Google Scholar search with the
search items ‘beta blocker hypertension left ventricular hypertrophy patient’ from 2013-2023. In the
end, a ‘snowball search’, based on the references of relevant papers as well as from papers that cited
them was performed.

Results:

HTN LVH is a risk factor for AF. In turn, AF substantially complicates HTN LVH and contributes
to the genesis of heart failure (HF) with preserved ejection fraction (HFpEF). The prognosis
of HFpEF is comparable with that of HF with reduced EF (HFrEF), and, regardless of the type, HF is
associated with five-year mortality of 50-75%. The antiarrhythmic properties of BBs are wellrecognized,
and BBs as a class of drugs are - in general - recommended to decrease the incidence of
AF in HTN.

Conclusion:

BBs are recommended (as a class) for AF prevention in several contemporary guidelines
for HTN. LVH regression in HTN - used as a single criterion for the choice of antihypertensive medication
- does not capture this protective effect. Consequently, it is worth studying how meaningful
this antiarrhythmic action (to prevent AF) of BBs is in patients with HTN LVH in addition to a
RAAS blocker.
Treatment of Menopausal Symptoms with Herbal Medicines: A Review
Authors: Wal Pranay , Singh Indu , Singh Deependra , Singh Manju Rawat , Wal Ankita
Published: November 2023

Background:

Menopause refers to the natural process of the “cessation of the menstrual
cycle.” This phase predominantly affects aged women and can lead to various symptoms such
as hot flashes, insomnia, night sweats, and sexual dysfunction, among others. Unfortunately,
many women remain unaware of this condition, and some even choose to overlook the symptoms.
However, those who recognize the symptoms consult with a doctor, who may recommend Hormone
replacement therapy (HRT). Initially, Hormone replacement therapy (HRT) can be effective,
but prolonged use can result in side effects. To mitigate these effects, there is a need to explore
and investigate herbal therapies as an alternative treatment for menopausal symptoms.

Objective:

The objective of this review is to explore and summarize various herbs used in managing
menopausal symptoms as an alternative to hormone replacement therapy.

Methods:

For this review, we conducted a literature survey spanning from 1998 to 2023. We used
keywords such as menopause, endocrinology, hormone replacement therapy, and herbs used for reducing
menopausal symptoms to search databases such as Google Scholar, PubMed, and SciDirect.
Relevant data were sourced from various journals like Plos One, JAMA, Frontier, Drug in
Context, MDPI, Molecules, BMC Women's Health, Research Gate, Heliyon, Elsevier, Taylor &
Francis, Nutrients, JMM, Wiley, OXFORD, Hindawi, Clinical Phytoscience, Pharmaceuticals,
Phytomedicine, and Menopause: The Journal of The North American Menopause Society.

Results:

The literature review encompassed 40 research articles and 200 review articles, including
randomized controlled trials. The findings revealed that several herbal plants, including Curcuma
longa, Zingiber officinale, Foeniculum vulgare, Trigonella foenum, Actaea racemosa, Glycyrrhiza
glabra, Oenothera biennis, Trifolium pratense, Humulus lupulus, Vitex agnus-castus, Valeriana officinalis,
Linum usitatissimum, Cannabis sativa, and Asparagus racemosus, have shown efficacy
in treating menopausal symptoms.

Conclusion:

In conclusion, medicinal plants can play a significant role in managing acute menopausal
syndrome. The intent of this review is to highlight the most recent research on estrogenic
plants for medicinal purposes and their therapeutic impact on cognitive deficiencies brought on by
estrogen shortage during menopause and aging.
Imaging Changes in Liver After Chemotherapy for Colon Cancer: A Case
Report
Authors: Lu Xuelin , Yang Shiping , Li Ting , Qin Zuoan , Zheng Chao
Published: November 2023

Background::

Colon cancer with liver metastasis is a common occurrence in clinical practice. The presence of liver metastasis has a significant impact on the
treatment strategy of patients, so the first step is to diagnose whether it is liver metastasis. Imaging is one of the auxiliary methods for diagnosing
liver metastases, but due to the presence of different diseases with the same shadow, we need to be cautious when using imaging methods for the
diagnosis of liver metastases.

Case Presentation::

We report a 53-year-old female patient with sigmoid colon cancer and perforation who underwent a surgical operation. Three years after the
operation, reexamination of the liver through computed tomography and magnetic resonance imagery scanning revealed multiple progressive liver
lesions. However, the liver biopsy did not show malignant changes. Repeated analysis of the patient's liver magnetic resonance imaging revealed
that multiple liver nodules were significantly enhanced in the arterial phase and that the portal vein density/signal ratio was higher than that of the
liver parenchyma. The coincidence of doughnut-shaped nodules and high signal in the hepatobiliary phase, combined with the results of
pathological liver puncture examination, led to nodular regenerative hyperplasia being considered as a possible diagnosis.

Conclusion::

A review of the relevant literature showed that following oxaliplatin chemotherapy for colorectal cancer, it is not uncommon for doughnut-shaped
nodules with obvious enhancement in the middle hepatic artery phase and high signal intensity in the hepatobiliary phase to develop. Such changes
should be paid sufficient attention by radiologists.
Bioactive Secondary Metabolites Produced by the Hadal Actinomycete
Streptomyces sp. SY1414 Isolated from the Mariana Trench-derived Sediment
Authors: Zhang Di , Feng Yao , Li Huifang , Zhang Zhizhen
Published: November 2023

Background::

Accumulated investigations have demonstrated that the Mariana Trench is
enriched in microorganisms. However, the diversity of structures and bioactivities of the secondary
metabolites produced by the Mariana Trench-associated microorganisms is poorly known, which
needs to be intensively investigated.

Objective::

This study aimed to investigate the bioactive secondary metabolites produced by a Mariana
Trench-derived actinomycete Streptomyces sp. SY1414 was cultured in BY medium, which was
chosen from four different media based on the diversity of secondary metabolites.

Methods::

A combination of different column chromatographs and HPLC was applied for the separation
and purification of the secondary metabolites. The structures of the isolated compounds were
determined mainly based on their NMR data, optical rotation values, and the comparison with the
reference data, and the Sulforhodamine B (SRB) method was used to evaluate the anti-glioma activity
of isolated compounds.

Results::

Four different types of compounds were isolated from the large culture of strain Streptomyces
sp. SY1414 in BY medium, including a benzoquinoline alkaloid, actinophenanthroline C (1), a
benzamide, (2E,4E)-5-(3-hydroxyphenyl)-penta-2,4-dienamide (2), a cyclopeptide, valinomycin (3),
and four macrolides of bafilomycin D (4), bafilomycin A2 (5), bafilomycin W (6), and C(19), C(21)-
O-methyl-bafilomycin A1 (7). Actinophenanthroline C (1), bafilomycin D (4), bafilomycin A2 (5),
and bafilomycin W (6) displayed significant anti-glioma activities with IC50 values ranging from
1.62 to 8.20 μM for U87MG cells and 2.45 to 3.89 μM for U251. The anti-gliomas of actinophenanthroline
C (1) was reported for the first time.

Conclusion::

The hadal actinomycete Streptomyces sp. SY1414 in BY medium produced four different
types of secondary metabolites with significant anti-glioma activity, which enriched the diversity
of structures and bioactivities of the Mariana Trench-associated natural products.
A Hidden Pandemic? Abuse of Gabapentinoids: A Brief Review of Recent Studies
Authors: Ispir Gamze Zengin , Danısman Mustafa , Katar Kubra Sezer
Published: November 2023

Background:

Gabapentin and pregabalin were developed for epilepsy and neuropathic
pain. They work via voltage-gated calcium channels and are used for broad-spectrum
diagnoses, e.g., epilepsy, neuropathic pain, other chronic pain syndromes, anxiety disorders,
alcohol-drug withdrawal syndromes, agitation, insomnia, etc. Especially in a world dealing with
the opioid crisis, gabapentinoids were considered safer alternatives to opioid analgesics.

Methods:

This review aims to comprehensively search and summarize recent studies concerning
the abuse of gabapentinoids published between 2021 and 2022 from various regions around
the world.

Results:

Studies have highlighted that a history of substance use disorder is a significant risk
factor for gabapentinoid abuse. Concurrent abuse of gabapentinoids with illicit drugs can exacerbate
drug-related damages. Drug screening and postmortem toxicology tests have revealed an
increase in gabapentinoid consumption. In response to the abuse potential, several countries
have classified gabapentinoids as controlled substances.

Conclusion:

Gabapentinoids are highly abused molecules worldwide. Physicians should be
aware of their abuse potential.
Identification and Phylogenetic Analysis of Venom Allergens from
Transcriptome of Hemiscorpius lepturus Scorpion
Authors: Kazemi-Lomedasht Fatemeh , Shahbazzadeh Delavar , Behdani Mahdi
Published: November 2023

Introduction:

Venom allergens have been identified in the venom of scorpion, snake, bee,
wasp, etc. Some allergy reactions in humans may refer to the venom allergens.

Aim:

Phylogenetic analysis of venom allergens from the transcriptome of Hemiscorpius lepturus scorpion was the main aim of the study.

Methods:

Seven venom allergens: HLAllergen1, HLAllergen2, HLAllergen3, HLAllergen4, HLAllergen5, HLAllergen6, and HLAllergen7 have been identified in the venom of Hemiscorpius lepturus
scorpion using venom gland transcriptome analysis. Primary, secondary and tertiary structures of the
identified venom allergens were predicted using ExPASy ProtParam, PSIPRED, and SWISS MODEL
servers. Phylogenetic tree was constructed using MEGA 11 software through neighbor-joining method
with 1000 bootstraps.

Results:

Structure analysis of identified venom allergens showed a molecular weight of between 46 to
52 kDa. Tertiary structure results showed that all predicted 3-D structures were in a normal range.
Phylogenetic tree analysis showed that HLAllergen 3, 4 and 5 were formed single clades and HLAllergen 1, 2, 7, and 6 other clades

Conclusion:

However, further studies using proteomic analysis of H. lepturus are needed to confirm
and compare with transcriptome data.
The Prospects of Lampung's Pepper Export to the Global Market: An Analysis Using the ARIMA Model
Authors: Putri Najah Hanifah , Abidin Zainal , Situmorang Suriaty
Published: November 2023

Pepper is one of Lampung's leading export commodities. It can be seen from the contribution of Lampung Province's pepper, which accounted for 42 percent of Indonesia's overall pepper exports. However, pepper production and export volume in Lampung Province continue to decline annually.  This study aims to analyze the prospect of Lampung’s pepper export to the international market for ten years, from 2023 - 2033. This research used ARIMA (Auto Regressive Moving Average) t model tool using E-views statistical software to forecast the trend of export of Lampung pepper to the International market. The data used was secondary data from the quarterly export of Lampung’s pepper from 2002 to 2022. The study suggested that  Lampung's pepper exports are projected to decrease from 2023 to 2033, with a decrease of 10 percent each year.  Finally, in 2033, Lampung's pepper exports to the international market only reached 998 tons.
The Impact of Trust and Relationship Quality on Agricultural Cooperative Competitiveness
Authors: Hardana Andrean Eka , Pratiwi Destyana Ellingga
Published: November 2023

In recent years, supply chains have received attention from researchers and business practitioners. Many studies have been conducted to identify what factors affect supply chain competitiveness. The purpose of this study is to determine the effect of trust and relationship quality on the supply chain of agricultural cooperatives. This study used Structural Equation Modeling (SEM) as the analysis method and used primary data collected from dairy producers or farmers, management staff of Agricultural Cooperatives, and retailers involved in the dairy supply chain in Malang District. The conceptual model consisted of four hypotheses. The results show that the hypotheses are proven, which means that the variables of trust, communication quality, and relationship quality have a positive effect on the competitiveness of Agricultural Cooperatives. The results also show that the competitiveness of Agricultural Cooperatives simultaneously affects the trust of producers or farmers in Agricultural Cooperatives. This means that the higher the competitiveness of Agricultural Cooperatives, the higher the trust of producers or farmers towards Agricultural Cooperatives.
Gender Critical Feminism in Mexico: Origins, Particularities, Attributes
Authors: Guerrero Mc Manus Siobhan , Stone Neuhouser Julianna
Published: November 2023

The rise of gender critical feminism in Mexico began in the year 2017 with the publication by Laura Lecuona of the now-infamous essay Cuando lo trans no es transgresor (“When Trans Is Not Transgressive”) (Guerrero Mc Manus, 2021a). In retrospect, trans-exclusionary feminism became prominent in a context in which two important developments were already occurring. On the one hand, in 2017, the Fourth Wave of Mexican feminism was already gaining influence on young women and LGBT+ populations. On the other hand, a year before, the Mexican anti-gender and anti-LGBT movement made a public demonstration of force with a national protest in which the Frente Nacional por la Familia (National Front for Family) expressed its opposition to what they described as “gender ideology” (Guerrero Mc Manus, 2016b). These two situations have since then become central in the particular rhetoric that we observe in this regional variety of gender critical feminism.
Spontaneous Scaling of a Primary Care Innovation in Real-Life Conditions: Protocol for a Case Study
Authors: Légaré France , G V Mochcovitch Diogo , de Carvalho Corôa Roberta , Gogovor Amédé , Ben Charif Ali , Cameron Cynthia , Plamondon Annie , Cimon Marie , Guay-Bélanger Sabrina , Roch Geneviève , Dumas Pilon Maxine , Paquette Jean-Sébastien , McLean Robert K D , Milat Andrew
Published: November 2023

Background

Scaling effective primary care innovations to benefit more people is of interest to decision makers. However, we know little about how promising innovations are being scaled “spontaneously,” that is, without deliberate guidance.

Objective

We aim to observe, document, and analyze how, in real-life conditions, 1 primary care innovation spontaneously scales up across Quebec, Canada.

Methods

We will conduct a participative study using a descriptive single-case study. It will be guided by the McLean and Gargani principles for scaling and reported according to the COREQ (Consolidated Criteria for Reporting Qualitative Research) guidelines. Informed by an integrated knowledge translation approach, our steering committee will include patient users throughout the project. Inspired by the Quebec College of Family Physician’s “Dragons’ Den” primary care program, we will identify a promising primary care innovation that is being or will be scaled spontaneously. We will interview the innovation team about their scaling experiences every month for 1 year. We will conduct interviews and focus groups with decision makers, health care providers, and end users in the innovation team and the target site about their experience of both scaling and receiving the scaled innovation and document meetings as nonparticipant observers. Interview transcripts and documentary data will be analyzed to (1) compare the spontaneous scaling plan and implementation with the McLean and Gargani principles for scaling and (2) determine how it was consistent with or diverged from the 4 McLean and Gargani guiding principles: justification, optimal scale, coordination, and dynamic evaluation.

Results

This study was funded in March 2020 by the Canadian Institutes of Health Research. Recruitment began in November 2023 and data collection began in December 2023. Results are expected to be published in the first quarter of 2024.

Conclusions

Our study will advance the science of scaling by providing practical evidence–based material about scaling health and social care innovations in real-world settings using the 4 guiding principles of McLean and Gargani.

International Registered Report Identifier (IRRID)

PRR1-10.2196/54855
The Artificial Third: A Broad View of the Effects of Introducing Generative Artificial Intelligence on Psychotherapy (Preprint)
Authors: Haber Yuval , Levkovich Inbar , Hadar-Shoval Dorit , Elyoseph Zohar
Published: November 2023

UNSTRUCTURED

This article explores a significant shift in the field of mental health in general and psychotherapy in particular, following artificial intelligence's new abilities in "understanding" and replicating human language. Following Freud, this lingo-technological development is conceptualized as the "fourth narcissistic blow" that science inflicts on humanity. We argue that this narcissistic blow has a potentially dramatic influence on perceptions of human society, inter-relationships, and the self. We should, accordingly, expect dramatic changes in perceptions of the therapeutic act, following the emergence of what we terms the "artificial third" in the field of psychotherapy. The introduction of an "artificial third" marks a critical juncture, prompting us to ask important core questions which address two basic elements of critical thinking, namely, transparency and autonomy: (1) What is this new artificial presence in therapy relationships?; (2) How does it reshape our perception of ourselves and our interpersonal dynamics?; (3) What remains of the irreplaceable human elements at the core of therapy? and; (4) What is beyond the interaction between the individual and the "artificial third"? Given the ethical implications that arise from these questions, this article proposes that the "artificial third" can be a valuable asset when applied with insight and ethical consideration, enhancing but not replacing the human touch in therapy.