Patients’ Reflections on Treatment Decision After Surgery for Laryngeal Cancer
Authors: Singer Susanne , Roick Julia , Gose Annegret , Oeken Jens , Herzog Michael , Pabst Friedemann , Plontke Stefan K. , Boehm Andreas , Dietz Andreas , Büntzel Jens , Vogel Hans-Joachim , Fabian Alexander , Wollenberg Barbara , Taylor Katherine , Gouveris Haralampos , Busch Chia-Jung , Guntinas-Lichius Orlando 
Published: June 2024

Importance

Clinicians should understand how patients who were treated with laryngeal cancer surgery think about this later on and what factors may be related with regretting surgery.

Objective

To assess variables associated with a positive attitude toward laryngeal cancer surgery.

Design, Setting, and Participants

This combination of 2 cohorts, based on patient interviews and questionnaires, was studied in 16 hospitals in Germany. Participants scheduled for laryngeal cancer surgery were enrolled before surgery and followed up until 1 year after surgery. Data collection began on November 28, 2001, and ended on March 15, 2015. Statistical analysis was performed from August 21, 2023, to January 19, 2024.

Main Outcomes and Measures

The attitude toward surgery was measured with the Psychosocial Adjustment After Laryngectomy Questionnaire (scores range from 0 to 100, with high scores representing a positive attitude toward the surgery) at 1 year after surgery. In multivariate regression analysis, the following variables were investigated: type of surgery, number of surgeries to the larynx, receipt of radiotherapy and chemotherapy, quality of life, speech intelligibility (objectively measured), age, sex, educational level, employment status, having a partner or not, counseling by patient association, and shared decision-making.

Results

Patients (n = 780; mean [SD] age, 60.6 [10.4] years; 701 [90%] male) who had received counseling from the patient association reported a more positive attitude toward surgery (adjusted B = 8.8; 95% CI, 1.0-16.6). Among patients after total laryngectomy, those with a university degree had a less positive attitude toward their surgery (adjusted B = −50.8; 95% CI, −84.0 to –17.6); this result was not observed in patients after partial laryngectomy (adjusted B = –4.8; 95% CI, −15.1 to 5.4). Among patients after partial laryngectomy, the attitude toward surgery was most positive in those who had experienced shared decision-making (mean [SD] questionnaire score, 84 [20] in those without a wish and 83 [20] in those with a wish for shared decision-making). Those who had wished they could decide together with the physician but where this eventually was not experienced expressed the most regret toward surgery (mean [SD] score, 71 [22]). There was no association between attitudes toward surgery and type of surgery (total vs partial laryngectomy) and all other variables tested.

Conclusion and Relevance

In this cohort study, most patients with head and neck cancer reported a positive attitude toward surgery, suggesting low levels of decision regret. Counseling by members of patient associations as well as individualized shared decision-making prior to surgery may have a positive impact on decision regret and is advisable in daily practice.