bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Short-Term Measurements to Estimate the Annual Mean Indoor Air Radon-222 Activity Concentration
Authors: Maringer Franz Josef , Blum Marius
Published: January 2025

In this work, a first trial of a method has been developed to estimate the average annual indoor radon activity concentration from three-week short-term measurements using active radon-222 measuring devices, considering relevant influencing parameters. 24 long-term measurements (6 months) and 50 short-term measurements (3 weeks) were carried out in 24 indoor spaces in private houses in four Austrian federal states between October 2022 and July 2023. At the same time as the short-term measurements, ambient parameters (outside and inside temperature, air pressure inside, outside, air humidity inside, outside, wind speed, wind direction, amount of precipitation) were also recorded to investigate their influence on the measured radon-222 activity concentrations. Building and usage data of the indoor spaces examined were also collected. Based on the evaluation of the radon-222 measurements carried out, a first guideline was developed for estimating the annual mean value of the radon-222 activity concentration from short-term measurements lasting around three weeks. Using further measurements and advanced physical-statistical methods, it would be possible to test, validate and improve the generalization of the method to indoor spaces and to further improve the functional relationships.
A Game-Based Scheme for Prime Minister Approval in Korea-Like Presidential Systems
Authors: Cheng Yiping
Published: January 2025

This paper addresses the issue of gridlocks in the approval of prime ministers in semi-presidential countries and presidential countries with prime ministers, focusing on the case of South Korea. A game-based scheme for prime minister approval specifically designed for presidential systems like Korea's is then proposed, along with two supporting provisions. The scheme has an adjustable parameter tentatively set at 3/5 to ensure a balanced system, and it also introduces a new form of cohabitation — hard cohabitation — where the prime minister is not nominated by the president. The supporting provisions aim to cope with two challenges likely to arise from hard cohabitation: potential cabinet instability and difficulties in cooperation between the president and the prime minister. By adopting a different transition model than in version 1.0, this version 2.0 resolves several issues identified, and introduces a mechanism absent in version 1.0, which is for the parliament to replace the prime minister following a midterm parliamentary election. The reform package proposed here is thus believed to be smooth, fair, and effective, and is strongly hoped to be adopted by South Korea or other similar countries in the future.
NanoBioAnalytical (NBA) Platform to Decipher Extracellular Vesicles Secreted by Microvascular Endothelial Cells Under Benzo[a]pyrene Exposure
Authors: Raizada Geetika , Guillouzouic Joan , Rouleau Alain , Lesniewska Eric , Le Ferrec Eric , Elie-Caille Céline , Boireau Wilfrid
Published: January 2025

Recent advancements in the clinical EV field highlight their potential as biomarkers for diverse diseases and therapeutic applications. This study provides an in-depth characterization of 10K EVs from human microvascular endothelial cells (HMEC-1) exposed to benzo-a-pyrene (B[a]P), a polycyclic aromatic hydrocarbon found in food and smoke. Given EVs’ complexity, with numerous surface and cargo proteins, phenotyping remains challenging. Here, we introduce a multiplex biosensor for profiling EVs from distinct cellular conditions, employing a multimodal approach that integrates surface plasmon resonance imaging (SPRi) and atomic force microscopy (AFM) to examine how cytotoxic environments impact EV biochemical and biophysical properties. SPRi experiments showed notable Evs capture differences ion ligands as Anti-CD36, Anti-CD81, and Anti-ApoA between treated and control conditions, likely due to B[a]P exposure. Complementary AFM scanning and statistical analyses revealed size differences between EVs from treated and control samples, with ligands like Anti-CD81, Anti-ApoA, Annexin-V, Anti-NOX2, and Anti-VEGFR1 emerging as ligands specific to potential cytotoxicity biomarkers. Our findings suggest that B[a]P exposure may increase EV size and alter marker expression, indicating phenotypic shifts in EVs under cytotoxic stress. This study highlights the utility of SPRi and AFM in identifying EV markers linked to cytotoxic responses, providing insights into EV heterogeneity in stress conditions.
Point-of-Care Diagnosis of Atrophic Gastritis by Serological Biomarker Test (GastroPanel® Quick Test) in Gastroscopy Referral Patients in India
Authors: Chhabra Mohinish , Kolatkar Ajit , Chawla Suresh , Joshi Aniket , Karjalainen Marika , Holopainen Heli , Hendolin Panu , Syrjänen Kari Juhani
Published: January 2025

Background: Increased demand of the serological biomarker test (GastroPanel®) in non-invasive diagnosis of gastric cancer (GC) risk conditions, i.e., atrophic gastritis (AG) and Helicobacter pylori (Hp) infection, prompted the design of GastroPanel® Quick test (GPQT)(Biohit Oyj, Helsinki, Finland) for point-of-care (POC) settings. Objective: This study validated the diagnostic accuracy (DA) of GPQT in diagnosis of AG and Hp among gastroscopy referral patients. Material and Methods: Altogether, 266 patients were enrolled among the consecutive gastroscopy referrals at the Department of Gastroenterology, Fortis Hospital (Mohali Chandigarh, India). All patients underwent gastroscopy with biopsies (n=249) classified using the Updated Sydney System (USS) and finger prick blood sampling for GPQT testing. Results: Biopsy-confirmed AG was found in 15.3% (38/249) of the patients. The overall agreement between the GPQT and the USS classification was 71.4% (95%CI 65.4-77.0%), with the weighted kappa (w) of 0.823 (95%CI 0.773-0.862). In ROC analysis for moderate/severe AG of the corpus (AGC) endpoint, AUC=0.990 (95%CI 0.979-1.000) and AUC=0.971 (95%CI 0.948-0.995) for PGI and PGI/PGII, respectively. Hp IgG Ab test detected biopsy-confirmed Hp with AUC=0.836 (95%CI 0.783-0.889). Conclusions: The accuracy of GPQT favourably competes with the ELISA test version (unified-GP) in diagnosis of AG and Hp in patients referred for diagnostic gastroscopy.
Spray-Drying Microencapsulation of Grape Pomace Extracts with Aginate-Based Coatings and Bioaccessibility of Phenolic Compounds
Authors: Martinović Josipa , Ambrus Rita , Planinić Mirela , Perković Gabriela , Šelo Gordana , Klarić Ana-Marija , Bucić-Kojić Ana
Published: January 2025

Spray-drying is a common technique for microencapsulation of bioactive compounds, which is crucial for improving their stability and bioavailability. In this study, the encapsulation efficiency (EE), physicochemical properties and in vitro bioaccessibility of phenolic compounds from spray-dried encapsulated phenol-rich extracts of grape pomace, a winery waste, were evaluated. Sodium alginate alone (SA) or in a mixture with gum Arabic (SA-GA) or gelatin (SA-GEL) were used as coatings. SA-GEL achieved the highest EE (95.90–98.01%) and outperformed the intestinal release of phenolics by achieving a bioaccessibility index (BI) for total phenolic compounds of 37.8–96.2%. The release mechanism of phenolics from microcapsules adhered to Fickian diffusion. Encapsulation significantly improved the BI of individual phenolics, with the highest BI values for gallocatechin gallate (2028.7%), epicatechin gallate (476.4%) and o-coumaric acid (464.2%) obtained from the SA-GEL microcapsules. Structural analysis confirmed amorphous matrices in all systems, which improve solubility and stability. These results suggest that encapsulation by spray-drying effectively protects phenolics during digestion and ensures efficient release in the intestine, which improves bioaccessibility. This study contributes to the understanding of biopolymer-based encapsulation systems, but also to the valorisation of grape pomace as a high-value functional ingredient in sustainable food processing.
CARAG: A Context-Aware Retrieval Framework for Fact Verification, Integrating Local and Global Perspectives of Explainable AI
Authors: Vallayil Manju , Nand Parma , Yan Wei Qi , Allende-Cid Héctor , Vamathevan Thamilini
Published: January 2025

This study introduces an explainable framework for Automated Fact Verification (AFV) systems, integrating a novel Context-Aware Retrieval and Explanation Generation (CARAG) methodology. CARAG enhances evidence retrieval by leveraging thematic embeddings derived from a Subset of Interest (SOI, a focused subset of the fact verification dataset), to integrate local and global perspectives. The retrieval process combines these thematic embeddings with claim-specific vectors to refine evidence selection. Retrieved evidence is integrated into an explanation generation pipeline employing a Large Language Model (LLM) in a zero-shot paradigm, ensuring alignment with topic-based thematic contexts. The SOI and its derived thematic embeddings, supported by a visualized SOI graph, provide transparency into the retrieval process and promote explainability in AI by outlining evidence selection rationale. CARAG is evaluated using FactVer, a novel explanation-focused dataset curated to enhance AFV transparency. Comparative analysis with standard Retrieval-Augmented Generation (RAG) demonstrates CARAG’s effectiveness in generating contextually aligned explanations, underscoring its potential to advance explainable AFV frameworks.
Real-Time Turning Movement, Queue Length and Traffic Density Estimation and Prediction from Probe Vehicle Data: A Kalman Filter Approach
Authors: Shafik Amr , Rakha Hesham A.
Published: January 2025

This paper introduces a bi-level Kalman filter algorithm to estimate and predict traffic states required for real-time traffic signal control. Leveraging probe vehicle and upstream detector data, turning movement (TM) counts in the vicinity of signalized intersections are estimated at the upper level, while the upstream approach density and queue sizes are estimated at the lower level. The proposed approach was evaluated using drone-collected and simulated data at a four-legged signalized intersection in Orlando, Florida. The results of the bi-level approach were quantified relative to the baseline estimation without a Kalman filter. Results show that the Kalman filter is effective in enhancing traffic state estimates at various market penetration levels, where the filter both improves the estimation accuracy over the baseline case and provides reliable state predictions. At the upper level, the standard deviation (SD) in TM estimates improves by up to 50%, compared to the estimates provided by the sole use of probe vehicle headings. The proposed approach also provides predictions with a minimal SD of 92.8 veh/h at a 5% level of market penetration. At the lower level, the proposed queue size estimation method results in an enhancement to the queue size estimation of up to 32.8% compared to the estimates obtained from the baseline approach. In addition, the estimated traffic density is enhanced by up to 18.5%. The proposed bi-level approach demonstrates the capability of providing reliable turning movement predictions across varying levels of market penetration. This highlights the readiness of this approach for practical application in real-time traffic signal control systems.
The Synergistic Impact of Glycolysis, Mitochondrial OxPhos, and PEP Cycling on ATP Production in Beta Cells
Authors: Grubelnik Vladimir , Zmazek Jan , Marhl Marko
Published: January 2025

We present a model of ATP production in pancreatic beta cells, focusing on ATP dynamics within the bulk cytosol, submembrane region, and microdomains near KATP channels. ATP is generated through glycolysis, the mitochondrial oxidative phosphorylation (OxPhos) and glycolytic pyruvate kinase-mediated phosphoenolpyruvate (PEP) production, supported by PEP cycling between mitochondria and the cytosol. The model examines ATP production in relation to Ca2+ oscillations, elucidating their interdependent dynamics. Our findings demonstrate that both mitochondrial OxPhos and PEP-mediated ATP production contribute substantially to cellular ATP levels. Specifically, glycolysis and mitochondrial OxPhos are crucial for the initial (first-phase) increase in bulk and subplasmalemmal ATP, effectively “filling up” the ATP pool in beta cells. In the second phase, coordinated cycling between OxPhos and PEP pathways enables cost-effective fine-tuning of ATP levels, with localized effects in the KATP channel microdomains. This model addresses and clarifies the recent debate regarding the mechanisms by which sufficient ATP concentrations are achieved to close KATP channels in glucose-stimulated beta cells, offering novel insights into the regulation of energy production and KATP channel activity.
Mediterranean Diet and Incidence of Global Warming on Food Habits and Plant Growth in Northern Mediterranean Latitudes
Authors: Latruffe Norbert , Lizard Gérard
Published: January 2025

Based on the consequences of global warming within 50 years from now, we can suppose to see a progression of the Mediterranean climate, in highest latitudes especially in the North-East of France, including Burgundy. The main challenge is to transform this change into an opportunity: adapt plant species (vegetables, trees, herbs, spices), and vineyards to new climates with methods having no or little environmental impacts and no negative consequences on human and animal health. The development of innovative methods of cultures with new socio-economical concepts seems crucial. The following objectives to consider are the advantage of keeping a local production associated with a reduction the carbon footprint (circular economy). The important sociological question is how can we stimulate people to embrace this new health-food approach, and encourage them to adopt it. Some proposals have been recently presented on a round table in Dijon, France on the topic « Which agriculture and food of the mediterranean diet in the next 50 years, in the septentrional area of France.
The key points developped in the review are the followings : - climate change and resulting consequences on food habits and plant growth;- impact on plant growth and characteristics ; - the modifications of food habits and consequences on health ; - healthy diet : the cretan or mediterranean diet, benefit proofs and perspectives ; - similarities of world places at the same mediterranean latitudes; - perspectives given by experts from a brain storming; - towards a need of societal adaptations of populations towards agriculture, food and cooking changes.
Dental Caries, Tooth Erosion and Nutritional Habits in a Cohort of Athletes: A Cross-Sectional Study
Authors: Mielle Baptiste , Júdice André , Proença Luís , Machado Vanessa , Vieira Ana M. , Mendes José João , Manso Ana Cristina , Rozan Cecilia , Botelho João
Published: January 2025

To study the association of dental caries and erosion in athletes with dietary and oral health habits. An observational cross-sectional study was conducted at the Sports Dentistry department of a university clinic. Intraoral examination included International Caries Detection and Assessment System (ICDAS II) index and the Basic Erosive Wear Examination (BEWE). A questionnaire was completed with sociodemographic data, dietary and oral hygiene habits. Inferential and multivariable regression analysis was performed to study the association of dental caries and erosion with confounding variables. A total of 80 athletes were included. The prevalence of dental caries and erosion was 50.0% and 40% respectively. Significant associations were observed between self-perceived oral health and caries lesions, with "Good" (Estimate: -5.01, p = 0.0009) and "Very good" (Estimate: -5.46, p = 0.0006) perceptions linked to fewer lesions. BEWE scores revealed significant associations with meal frequency uncertainty (Estimate: -12.56, p = 0.014) and uncertainty about the last dental visit (Estimate: 8.82, p = 0.014). Self-perceived oral health as "Good" or "Very good" was associated with lower dental erosion (p < 0.01). Other demographic and behavioral factors were not significantly associated with caries or erosion. This cohort of athletes exhibited a high prevalence of dental caries. and erosion, with associated dietary and oral hygiene habits. These results highlight the need for targeted dietary counseling and oral health education for athletes, whose nutritional needs may lead to increased consumption of sugar-rich diets.
Sustainable Bacterial Cellulose Production Using Low-Cost Fruit Wastewater Feedstocks
Authors: Mouro Cláudia , Gomes Arlindo , Gomes Ana P. , Gouveia Isabel C.
Published: January 2025

Bacterial cellulose (BC) is a versatile biopolymer prized for its remarkable water absorption, nanoscale fiber architecture, mechanical robustness, and biocompatibility, making it suitable for diverse applications. Despite its potential, the high cost of conventional fermentation media limits BC’s scalability and wider commercial use. This study investigates an economical solution by utilizing fractions from fruit processing wastewater, refined through sequential membrane fractionation, as a supplement to commercial HS medium for BC production. BC films were thoroughly characterized using Fourier transform infrared spectroscopy (FTIR), scanning and transmission electron microscopy (SEM and TEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and assessments of mechanical properties and water holding capacity (WHC). FTIR confirmed the BC structure, while SEM and TEM validated its nanofibrillar 3D network. XRD showed increased crystallinity with the wastewater fractions, and DSC revealed a slight increase in thermal stability for F#6. Adding these fractions notably improved the BC films' tensile strength, Young's modulus, and WHC. Overall, the results underscore that fruit processing wastewater fractions can serve as a cost-efficient, eco-friendly alternative to traditional fermentation media. This approach supports circular economy principles by lowering reliance on intensive wastewater treatments, promoting waste valorization, and advancing sustainable production methods for high-value biopolymers.
Aging of Red Wine (cv. Negroamaro) in Mediterranean Areas: Impact of Different Barrels and Apulian Traditional Amphorae on Phenolic Indices, Volatile Composition and Sensory Analysis
Authors: Prezioso Ilaria , Corcione Giuseppe , Digiorgio Chiara , Fioschi Gabriele , Paradiso and Vito Michele
Published: January 2025

This study investigated on the impact of different aging containers on the volatile composition and quality of Negroamaro wine, a key variety from Apulia, Italy. Seven vessel types were evaluated: traditional Apulian amphorae (ozza), five types of oak barrels (American oak, French oak, European oak, a French + European oak, and a multi-wood mix), galls bottles as control. The impact of the vessels was evaluated after 6 months aging through characterization of phenolic, volatile and sensory profiles. Amphorae allowed a specific evolution of the wine’s primary aromas, including as fruity and floral notes, while enhancing volatile compounds like furaneol, which contributes to caramel and red fruit nuances and also 3-methyl-2,4-nonanedione, a key compound related to anise, plum and premature aging, depending on its concetration. This container also demonstrated effectiveness in stabilizing anthocyanin-tannin complexes, supporting color stabilization. Oak barrels allowed to obtain different outcomes in terms of color stabilization, volatile profile, aroma and astringency. French oak exhibited the highest phenolic and tannin levels, enhancing anthocyanin stabilization and color intensity. European oak followed closely, while American oak excelled in color stabilization with tannins less reactive to polymers. Mixed wood barrels showed lower phenolic extraction and the best astringency evolution.
Jesus and the Roman Empire: A Theological Perspective on Political Power, Ideologies, Extremism and Religious Nationalism
Authors: Buzguta Corneliu Ben
Published: January 2025

This article presents a theological examination of the distinction Jesus makes between the power of God and worldly, politico-military authority, particularly as manifested in the Roman Empire. Grounded in Gospel texts, particularly Luke 20:25 and Matthew 20:25–28, the analysis explores the contrasting values of divine power, which is characterized by love, peace, and reconciliation, against earthly power, defined by authority, coercion, manipulation, and brute force. The article delves into the meanings of political power, ideologies, and the dangers of religious nationalism and extremism, drawing conceptual boundaries between these forms of influence. Using the Roman Empire as a case study, the article reveals how Jesus critiques political authority in favor of the Kingdom of God, whose values stand in direct opposition to the ideologies of worldly power. This exploration further addresses the risks of ideological extremism, particularly within religious contexts, and emphasizes the theological importance of distinguishing between worldly governance and divine sovereignty. Ultimately, the Kingdom of God, as portrayed in the Gospels, is a realm of love, justice, and peace, while worldly systems often promote conflict and division. The article concludes by offering a model for Christians, based on Christ’s teachings, to navigate the tensions between faith and political ideologies, keeping in focus the priorities of God's Kingdom and the power of divine love.
Cardiopulmonary Functional Profiles in Cancer Therapy-Related Cardiac Dysfunction Among Patients with Non-Hodgkin Lymphoma
Authors: Bursacovschi Daniela , Revenco Valeriu , Robu Maria , Arnaut Oleg
Published: January 2025

Background: Non-Hodgkin lymphoma (NHL) is associated with significant cardiovascular risks due to treatment-related toxicities, including cancer therapy-related cardiac dysfunction (CTRCD). While multimodality imaging, particularly echocardiography, is pivotal in monitoring cardiac function, the prognostic role of cardiopulmonary exercise testing (CPET) in predicting CTRCD remains underexplored. Methods: This prospective study included 127 patients with NHL assessed before initiating antitumor treatment and at six months follow-up using echocardiography and cardiopulmonary exercise testing. Results: Our found that asymptomatic CTRCD occurred in 14.2% of NHL patients at six months of treatment. Patients with CTRCD exhibited significantly lower median work rates, volume of oxygen (VO₂) at the anaerobic threshold, and O₂ consumption efficiency, reflecting compromised metabolic and functional performance. Baseline peak oxygen consumption (VO₂ peak) positively correlated with left ventricle ejection fraction (LVEF) at six months, while VO₂ peak < 14 ml/kg/min was negatively associated with LVEF. Conclusions: Asymptomatic CTRCD was identified in 14.2% of NHL patients at six months, with lower work rates, VO₂ at the anaerobic threshold, and O₂ consumption efficiency indicating impaired performance. Baseline peak oxygen consumption correlated positively with LVEF, highlighting CPET's potential for early CTRCD risk assessment.
Bibliometric Analysis: Research Trends In Vitamin D And Magnesium as A Diabetes Mellitus Therapy Model (2013-2024)
Authors: Faizah Azzahra Balqis , Yueniwati Yuyun , Permatasari Happy Kurnia
Published: January 2025

Pendahuluan: Diabetes Melitus (DM) merupakan masalah kesehatan global yang serius. Penelitian ini bertujuan untuk mengetahu bagaimana kombinasi Vitamin D dan magnesium dapat memberikan manfaat sinergis yang digunakan sebagai terapi diabetes melitus.
Metode: Penelitian ini menggunakan database Scopus untuk mengumpulkan dan menganalisis artikel yang relevan. Sebanyak 410 artikel dimasukkan untuk analisis bibliometrik. Data dianalisis menggunakan software Vos Viewer versi 1.6.19, Microsoft Excel, dan Biblioshinny versi R 4.3.0
Hasil: Sebanyak 410 artikel dimasukkan untuk dianalisis. Temuan tersebut mengungkapkan tren peningkatan penelitian tentang vitamin D dan magnesium dalam beberapa tahun terakhir. Negara yang dominan dalam publikasi adalah Amerika Serikat. Artikel ilmiah mendominasi jenis publikasi dengan persentase sebesar 70,7%. Penulis paling produktif adalah Bener A dan Martinez Gonzalez M.A, masing-masing dengan 4 dokumen. Jurnal "Nutrisi" adalah sumber utama yang membahas topik ini secara ekstensif. Bidang studi yang paling dominan adalah bidang kedokteran dengan persentase 51,7%. Isu hangat dan potensial di masa depan divisualisasikan melalui VOSviewer dengan warna kuning, termasuk kontrol glikemik, mikronutrien, pola makan, asam lemak Omega-3, dan vitamin.
Kesimpulan: Analisis bibliometrik ini memberikan wawasan status penelitian terkini mengenai peran vitamin D dan magnesium pada Diabetes Mellitus. Temuan ini penting untuk memandu arah penelitian dan kolaborasi di masa depan, serta menawarkan perspektif dan strategi baru untuk pencegahan dan pengobatan Diabetes Mellitus.
SUSTAINABLE ACHIEVEMENT SPORTS DEVELOPMENT PROGRAM IN DKI JAKARTA PROVINCE (Evaluation Study in Swimming)
Authors: PRANAJAYA IKROOM , Abdul sukur  , Aan Wasan
Published: January 2025

ABSTRACT
Competitive performance sports require achieving maximum performance for those who pursue it either individually, in groups or as teams. This means that achievement in sports is the final goal that must be achieved in a sports activity. To achieve this, one way that can be done is through coaching efforts through the implementation of programmed training in a systematic, directed and continuous manner. DKI Jakarta Province implements the Sustainable Achievement Sports Development Program which adapts the long-term development model from Balyi. This research aims to evaluate the DKI Jakarta Province Sustainable Sports Achievement Development Program, especially in swimming in 2023. This research uses the CIPP evaluation model from Stufflebeam including Context, Input, Process and Product. This research was carried out from February to August 2024 at the Sustainable Sports Achievement Development Program at the DKI Jakarta Provincial Youth and Sports Service.
Keywords: Evaluation, Context, Input, Process and Product, Sustainable Performance Sports Development Program, Swimming
SURVEY LEVEL OF UNDERSTANDING OF PHYSICAL ACTIVITY AND PHYSICAL ACTIVITY LEVEL AND ANTHROPOMETRIC STATUS
Authors: Arika Umi Zar in  , Imam Sugeng  , Roudhotul janah
Published: January 2025

Students of Physical Education Health and Recreation Faculty of teacher training and education are prepared to become competent educators in the field of sports. One of the skills competencies required is understanding and skills in measuring physical activity levels, understanding physical activity and anthropometry.  The purpose of this study was adalah to determine and understand the measurement aktivitas of physical activity, understanding of physical activity and anthropometric status of students of Physical Education Health and Recreation FKIP. This study is cross-sectional research on students who administer the test and measurement of sports. Understanding of the level of physical activity measured by metode the test method, the level of physical activity was measured using a questionnaire GPAQ (global Physical Activity Questionanire) and tipe body type or somatotype was measured based on the health Charter Manual.
Then the data is processed in a descriptive and correlation Person to determine the relationship between the level of understanding of physical activity, physical activity level and anthropometry using SPSS. The results showed that in all students who manage the course of sports tests and measurements have level a good level of physical activity baik GPAQ score an average of 7248.13 ° 2420.5 METs. Correlation test showed positive correlation between the level of understanding of physical activity and physical activity level correlation p < 0.05.
THE CORRELATION OF AGE AND VISCERAL FAT WITH TOTAL CHOLESTEROL
Authors: Yuliasih  , Nurdin Fatah , Tangkudung Albert Wolter Aridan , Chandra
Published: January 2025

This study aims to determine the correlation between age, and visceral fat with total cholesterol. The method used is a cross-sectional approach. For the population of RPTRA visitors in East Jakarta, the sampling technique with accidental sampling is based on chance. The result of this study is that age (X1) to total cholesterol (Y) correlates to 0.290. While visceral fat (X2) to total cholesterol (Y) correlates to 0.432, there is a moderate correlation between visceral fat and total cholesterol. So, age does not affect total cholesterol or visceral fat. Some of the factors that affect the increase in cholesterol are diet and activity.
Improving The Teachers Instructional Capacity through Assistance in Creating Microlearning-Based Learning Media
Authors: Maisyaroh  , Juharyanto  , Amirul Adha Maulana , Lesmana Indra , Angelie Hanika , Fadhila Isadatul
Published: January 2025

This community service activity aims to provide insight and knowledge of microlearning learning media for teachers in laboratory elementary schools. The training and mentoring approach is used in this community service activity. This community service activity is carried out through the stages of socialization, training, technology application, mentoring and evaluation, and program sustainability. At the evaluation stage, it was carried out with pre-test and post- test sheets which were then analyzed using the SPSS 24.0 program. Based on the results of post-test calculations, there was a significant improvement in the skills of participants before and after participating in training activities. Thus, it can be concluded that there is a need for regular training and mentoring activities, especially in increasing the instructional capacity of teachers in the current digital era. Through this community service activity, it is hoped that it will be able to produce a teaching module and post-activity monitoring.
Evidence Versus Frenzy in Robotic Total Knee Arthroplasty
Authors: Ekhtiari Seper , Sun Bryan , Sidhu Rabbea , Ade-Conde Ayomide Michael , Chaudhry Harman , Tomescu Sebastian , Ravi Bheeshma , Mundi Raman
Published: January 2025

Background:

Robotic total knee arthroplasty (rTKA) has garnered increasing attention in recent years, both clinically and in the media. The purpose of this study was to compare the volume of and messaging in published randomized controlled trials (RCTs) versus media reports on the topic of rTKA.

Methods:

This was a systematic review of RCTs and media articles on rTKA. PubMed, Embase, and MEDLINE were searched for RCTs; Factiva was searched for media articles. The number of publications of each type per year was recorded. Media articles were classified on the basis of their primary information source, their general tone toward rTKA, and the benefits and drawbacks of rTKA discussed. The volume, tone, and specific messaging around rTKA were compared between media articles and RCTs.

Results:

Fifteen RCTs and 460 media articles, published between 1991 and 2023, were included. The rates of both publication types increased over time, with more rapid increases in recent years. Ninety-five percent of media publications highlighted at least 1 benefit of rTKA. The most commonly cited benefits were more precise implant positioning (82.6%) and faster recovery (28.7%). Fewer than 7% of media publications (n = 30) mentioned downsides to rTKA. Overall, 89.3% of media articles presented a favorable view of rTKA. Ninety percent of RCTs reported that rTKA significantly outperformed manual TKA in terms of component positioning. Four of 6 RCTs reported significantly longer operative times with rTKA. Most RCTs found no significant differences in functional outcomes, opioid use, or complication rates.

Conclusions:

The rate of publications on rTKA has increased substantially in media sources and peer-reviewed journals, with the volume of media articles far outpacing RCTs on the topic. More precise component positioning was the most consistently reported benefit of rTKA in RCTs. However, media sources also reported a range of other, less well-supported benefits, and employed overwhelmingly positive tones regarding rTKA, more so than is supported by mixed clinical results. Efforts to ensure that patients and health-care providers receive accurate and evidence-based information about new health technologies are critical.

Clinical Relevance:

This study demonstrates a clear disparity between news media coverage of rTKA and the best clinical evidence available. This information can help to guide discussions between patients and surgeons regarding the use of rTKA.
ENHANCING VOLTAGE STABILITY AND ENERGY OUTPUT OF PLTM SALIDO IN THE PLN DISTRIBUTION NETWORK
Authors: Alfith Alfith , Indriani Rani , Bandri Sepannur
Published: January 2025

Distributed generation (DG) integration in PLN’s extended distribution network often encounters voltage instability issues due to high voltage drops. These challenges restrict power delivery and can lead to disconnection, particularly during peak load conditions. This study investigates methods to enhance voltage stability and optimize the energy output of PLTM Salido. Using ETAP Power Station software, various operational schemes were simulated to address the problem of low terminal voltage. The study focused on the impact of reactive power injection and governor settings optimization to maintain generator performance under high demand. Results indicate that reactive power injection significantly improves terminal voltage, ensuring continuous power delivery. Adding a third generator unit further increased energy supply capacity, leveraging the full potential of available hydropower. The optimized operation of PLTM Salido with two generators increased daily energy output by 32.2%, while introducing a third generator boosted energy delivery by 107%. This research highlights the critical role of reactive power management and system configuration in enhancing the performance of small-scale hydropower plants in rural distribution networks.
Exactitud del método de mincer para la estimación de edad dental mediante radiografías panorámicas digitales en una población hondureña
Authors:   , Cáceres Vásquez Irma Yesenia
Published: January 2025

Objetivo. Determinar la exactitud del método de Mincer para estimar la edad dental (DA) mediante radiografías panorámicas (PR) digitales en una población hondureña de 14 a 22 años. Metodología. Este estudio observacional, transversal, retrospectivo se aplicó en una muestra de 134 PR digitales de un centro dental privado de Comayagua (72 mujeres y 62 varones; edad media 18±3 años). Una observadora calibrada (kappa≥0.83) analizó la DA con el método Demirjian y Mincer en todos los terceros molares (3M) desde el estadio D (corona completa) al H (cierre ápice) diferenciando por sexo. La DA decimal de cada individuo se calculó del promedio de las cuatro 3M. La estimación de la edad cronológica (CA) según el método Mincer se obtuvieron con fórmulas de regresión lineal. Resultados. La media y error estándar de la diferencia de CA y DA fue de 0.58±0.13 años (varón 0.5±0.19 y mujer 0.65±0.19). Los grupos etarios mostraron una mayor sobrestimación (>1.1) de 14 a 17 años (50 a 100%), coincidencia (±1,1 años) a los 18 años (66,7 a 70%) y subestimación (<-1.1) de 21 y 22 años (42,9 a 100%) (p=0.000). Las ecuaciones de predicción de CA según DA fueron estadísticamente significativas (P=0.000) con explicación del 66.5% en muestra total (error=1.465), 84.5% en varones (Error=1.367) y 79,3% en mujeres (error=1.548). Conclusión. El método de Mincer obtuvo una predicción razonable para estimar la mayoría de edad con mejora en los ajustes con la fórmula de estimación de edad en una población específica de Comayagua en Honduras.
Incidencia de la depresión postparto evaluado mediante la Escala de Hamilton y sus factores asociados, en primigestas atendidas en el Hospital Nacional Docente Madre Niño San Bartolomé durante el período de diciembre del 2022 a marzo del 2023
Authors:   , Cuadros Galindo Karla Veronica , Diaz Gayosa Ana Elisa
Published: January 2025

Esta investigación fue titulada “Incidencia de la depresión postparto evaluado mediante la escala de Hamilton y sus factores asociados, en primigestas atendidas en el Hospital Nacional Docente Madre Niño San Bartolomé durante el período de diciembre del 2022 a marzo del 2023”. El objetivo fue “Determinar la incidencia de depresión postparto a través del uso de la escala de Hamilton en primigestas adolescentes y adultas, atendidas en el Hospital Nacional Docente Madre Niño San Bartolomé”. El método usado en el estudio fue el enfoque cuantitativo, retrospectivo, analítico, observacional, transversal y con uso de datos secundario. Se realizó en una muestra de 204 primigestas y se les aplicó la escala de Hamilton para poder medir las variables. Los resultados que se obtuvieron mediante Chi cuadrado arrojaron el valor p= < 0.05 que permite afirmar una alta incidencia de depresión postparto en primigestas adolescentes y adultas donde los factores con mayor asociación son edad > de 30 años (56.4%), estado civil soltera (44.6%). Parturientas con estudios de secundaria (62.7%), pertenecer al estrato socioeconómico medio-bajo (58.3%), parto natural (75.0%), con depresión antes del embarazo (87.7%) y experimentación de hechos de violencia antes del embarazo (77.5%): Se concluye que la depresión postparto se asocia con factores sociodemográficos, biológicos y psicológicos.
Estudio del potencial del glicerol alcalino de la industria pesquera como co-sustrato en la producción de biogás
Authors:   , Belsuzarri Poma Lizet Rocio
Published: January 2025

La presente investigación tuvo como objetivo evaluar el potencial del glicerol alcalino de la industria pesquera como co-sustrato en la generación de biogás. Se organizaron cuatro ensayos utilizando biodigestores tipo batch, cada uno con distintas concentraciones de glicerol alcalino proveniente de pescado: el tratamiento control (C) con un 0% de glicerol alcalino de pescado, el tratamiento 1 (T1) con 3%, tratamiento 2 (T2) con 6% y el tratamiento 3 (T3) con 9%. Antes de iniciar la biodigestión, se caracterizó los sustratos de cada tratamiento donde se analizó los sólidos totales (ST), sólidos volátiles (SV) y el potencial de hidrógeno (pH); además durante el proceso de la biodigestión se registraron semanalmente el pH, temperatura y concentración de metano (CH4) cada dos días a lo largo de un período de nueve semanas.. Los resultados obtenidos fueron que los cuatros tratamientos tuvieron un aumento de concentración de CH4: el tratamiento control aumentó a 71%; el tratamiento T1 aumentó de 54% a 64%; el tratamiento T2 aumentó de 73% a 85%; y finalmente el tratamiento T3 aumento de 62% a 70%. Al realizar las pruebas estadísticas, se comprobó que el tratamiento T2 presentó una diferencia significativa (p=0.00) a comparación con el tratamiento control, lo cual determina que si existe un valor agregado del glicerol alcalino de pescado como co-sustrato para el proceso de producción de biogás.
EFFECTIVENESS OF STEM CELL THERAPY IN MYOCARDIAL INFARCTION BASED ON ENZYME ACTIVITY AND LIVER HISTOPATOLOGY
Authors: Rahmi Riska Asria Sa'adatur , Gunanti Gunanti , Noviana Deni , Harlina Eva
Published: January 2025

This research aims to study the effectiveness of single placenta stem cell therapy (ST) or a combination of cardiomyocyte co-cultures in pigs with myocardial infarction based on enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity as well as liver histopathology. Nine pigs were divided into three treatment groups (K1, K2, and K3) consisting of three pigs per group. Blood sampling was performed one-hour pre-surgery, post-ST-elevation, and eight weeks post-therapy. The experimental animals were treated for eight weeks, then euthanized and necropsied for liver removal. ALT and AST values were analyzed using one-way analysis of variance (ANOVA) and followed by Tukey's test. Histopathological changes in liver tissue were analyzed using Image J 1.53 software, and the measured data were analyzed using oneway ANOVA. The results showed an increase in the ALT and AST values of the three treatment groups on post-ST-elevation blood sampling but were still within normal limits except for K1. ALT and AST values decreased significantly (P0.05) in the group treated with single placental stem cell (K2) or combined cardiomyocyte co-culture (K3). The ALT value of K3 decreased but not significantly (P0.05) compared to K2. The AST value of K3 decreased significantly (P0.05) but was not significantly different (P0.05) compared to K2. The liver tissue showed circulatory disturbances in the central venous congestion, portal vein, sinusoidal dilatation and congestion, and hepatocyte changes in the form of centrilobular necrosis and hydropic degeneration. Stem cell therapy alone (K2) or in combination with cardiomyocyte co-culture (K3) had similar percentage of  centrilobular necrosis which was significantly lower than K1 (P0.05). Hepatocyte hydropic degeneration on K2 was classified as mild, whereas on K3 was classified as moderate. As conclusion, administration of placental stem cell therapy alone or in combination with cardiomyocyte co-culture can reduce ALT and AST values and could repair liver tissue.
WITHDRAWN: Relative Importance Analysis Of Female Factors In Total Labor Force Participation
Authors: HUSNUOGLU Nadide , ODA Volkan
Published: January 2025

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Pancentromere landscape and dynamic evolution in Brassica plants
Authors: Guo Li , Chen Weikai , Wang Jingxuan , Chen Shaoying , Meng Dian , Mu Yu , Hui Feng
Published: January 2025

Centromere paradox where functionally conserved centromeres exhibit rapid evolution has long intrigued geneticists and evolutionary biologists. Despite its importance, centromeric landscape remains poorly understood due to its assembling challenge. Here, we dissect the dynamic evolution of Brassica centromeres by generating telomere-to-telomere assemblies from seven morphotypes of B. rapa (AA) and two tetroploids B. juncea (AABB) and B. napus (AACC). Pan-centromere analysis reveal that Brassica centromeres are extensively invaded by retrotransposons and show remarkable diversity in size and structure. While A- and C-genome centromeres are featured by distinct patterns of satellites, B-genome centromeres are devoid of satellites. Interestingly, the centromeric satellite expansion in the C-genome is reminiscent of the layered expansions observed in human centromeres. Accordingly, we propose a working model of centromere evolution reconstructing the key evolutionary events leading to current centromere structures. These insights will illuminate plant centromere evolution and guide the design of crop synthetic chromosomes.
Large-array sub-millimeter precision coherent flash three-dimensional imaging
Authors: Zhang Weifeng , Wang Bin , Tian Junze , Wang Jianwei , Zhao Shuangxiang , Duan Jianhao , Liu Yangyang , Zeng Tao , Mao Erke
Published: January 2025

High-precision three-dimensional (3D) imaging is essential for accurately perceiving environments, providing critical depth and spatial awareness. Among the various reported approaches, solid-state LiDAR systems have garnered significant attention. However, depth precision, detection range and pixel scalability remain key challenges for their widespread adoption. Here, we report a large-array coherent flash 3D imaging system that achieves a sub-millimeter range precision through stepped-frequency modulation and coherent detection with CCD sensors. A coherent image sensor is developed, and a prototype system is demonstrated, providing 3D imaging with a depth precision as high as 0.47 mm over a range of 30.50 m at an optical power of 15.85 mW. Our system features high range precision, exceptional sensitivity across long distances, and robust pixel scalability by directly leveraging well-established CCD sensors. This advancement introduces a scalable and versatile approach to long-range high-precision 3D imaging, with substantial implications for virtual reality, cultural heritage restoration, biomedical imaging, and industrial applications.
Accurate Detection of Bright Spots in Electro-Luminescence Images of Photovoltaic Panels
Authors: Nair Rahul , Thirwani Anand , Kulkarni Kedar
Published: January 2025

Safe and efficient operation of photovoltaic (PV) solar panels depends on early defect detection during manufacturing. ‘Bright spots’ on Electro-Luminescence (EL) images of Photovoltaic (PV) solar panels are critical defects, leading to excess energy production, short circuits, overheating, and potential fires. After extensive benchmarking against state-of-the-art methods, this paper proposes a robust approach for reliable bright spot detection based on image classification using novel features and synthetic bright spot EL images generated by generative adversarial networks (GANs). The proposed approach achieved an area under the precision-recall curve (AUPRC) of 0.9526 signifying its real-world applicability for reliable bright spot detection in PV solar panels.
CCS CONCEPTS
• Computing methodologies • Machine learning approaches.
Evaluation of Lubricating Ability of Solid Lubricants in Diamond Grinding of Difficult-to-machine Materials
Authors: Rudnev Aleksandr , Titarenko Oksana , Kotliar Alexey , Gasanov Magomediemin , Kalinin Pavel
Published: January 2025

Titanium alloys and nickel-based stainless steels are attractive materials for the aerospace industry because of high-strength, heat resistance, corrosion resistance. However, these materials are notorious for poor thermal properties and are classified as difficult-to-machine materials. The problems are attributed to the high specific energy and the large amount of cutting fluid consumed. Paper presents the results of the elimination of fluid coolants by solid lubricants (SLs) in diamond grinding of titanium alloy VT22 and heat-resistant stainless steel 10Cr11Ni23Ti3MoB. To study the impact of various compositions of SL on grinding performance, the cutting force and surface roughness were evaluated and compared with dry grinding. The best lubricating ability in grinding with low feeds has stearic acid (steel) and stearic acid with boron nitride (VT22). A good lubricating ability in grinding with increased feeds has stearic acid with boron nitride (steel) and stearic acid with molybdenum disulfide or with boron nitride (VT22).