bluuebunny/crossref_metadata_2025 huggingface dataset:
Playful Approaches to Leadership Development: Three Innovative Uses of Games in the Classroom
Authors: Schrier Karen , Zahradnik Anne , Shaenfield David
Published: December 2023

How can educators use games and playful interactions to enhance the practice of skills related to leadership and management? Effective leadership involves a number of skills, such as strategic thinking, perspective-taking, critical thinking, ethical thinking, resource management, and reflection on one’s biases. In this article, we will review how three different instructors use games and play in their higher education classrooms to teach critical leadership skills. We will share how we use three different types of games: (1) a commercially-available off-the-shelf digital game ( Democracy 4) to enhance resource management and ethical thinking skills; (2) a non-digital card game ( @Stake Game) to teach critical thinking and argumentation; and (3) an independent (indie) digital game ( SweetXHeart) to teach bias reduction and perspective-taking. We will share best practices and recommendations for using games in leadership and management education.
Glandular Crowdings in Endometrial Polyps: Clinical Follow-Up and Possible Worrisome Features
Authors: Koç Nermin , Ertürk Coşkun Ayşe Deniz
Published: December 2023

Introduction

Interpretation of changes and premalignant lesions in endometrial polyps can be challenging. We evaluated the clinical course of patients with focal gland crowdings in endometrial polyps via repeat biopsies and searched for possible morphological findings in the initial biopsy that may foresee a premalignant course.

Methods

Specimens diagnosed as endometrial polyp and focal gland crowding in patients who had a repeat biopsy in a 1-year period were reexamined. Morphological findings in the initial biopsies were recorded. The group whose repeat biopsies were “premalignant or malignant” (Group 1), and the group with “benign” repeat biopsies (Group 2) were compared.

Results

“Endometrial polyp and gland crowdings” was diagnosed in 115 specimens of which 38 patients had repeat biopsies. Among these 8 (21%) were diagnosed as “endometrial intraepithelial neoplasia (EIN)” (Group 1) and 30 (79%) as “benign” (Group 2). Morphological features in the initial biopsies were evaluated; PAX2 loss was 6 of 8 (75%) for Group 1 and 7 of 30 (23%) for Group 2 ( P = .020), and altered epithelial cytological features were present in 5 of 8 (62%) versus 4 of 30 (13%) ( P = .015), both significantly higher in Group 1. Dark intraluminal secretion, intraluminal histiocytes, intraglandular epithelial proliferation, and mean diameter of crowded gland areas were not statistically different between the 2 groups.

Conclusion

“Focal gland crowdings” in endometrial polyps do carry a risk of EIN in subsequent biopsies. We suggest that the loss/decrease of PAX2 and altered epithelial cytological features in these areas in the initial biopsy are indicative of a premalignant course.
Fault diagnosis of rotor systems with breathing slant cracks based on nonlinear output frequency response functions
Authors: Zhi-nong LI , Yun-long LI , Heng-heng XIA , Shi-yao CHEN , Fei WANG
Published: December 2023

When it comes to practical engineering, there is a high likelihood of shafts developing slant cracks due to torque transmission. These cracks exhibit breathing characteristics, repeatedly opening and closing under gravity and radial forces. To diagnose rotor systems with breathing slant cracks, the nonlinear output frequency response functions (NOFRFs) method is introduced. Firstly, a dynamic model of rotor systems with breathing slant cracks is established, and the system's frequency spectra are obtained by solving the model with different crack angles, depths, and positions. Secondly, the NOFRFs values at different orders are derived based on the NOFRFs theory. The simulation results display increased nonlinear characteristics with crack angle and depth. The system's nonlinear characteristics are stronger when cracks are closer to the disk. The [Formula: see text] value for the first-order is sensitive to crack angles, the [Formula: see text] value for the second-order is sensitive to crack depths, and the [Formula: see text] value for the fourth-order is sensitive to crack positions. As a result, the NOFRFs response at different orders can detect variations in angles, depths, and positions of the breathing slant crack. Finally, experiments are conducted on a rotor system with breathing slant cracks, and the results match those of the simulation, indicating that the NOFRFs method is feasible for identifying breathing slant cracks.
Interruptions in Insurance Coverage and Prescription Drug Utilization: Evidence from Kentucky
Authors: Meille Giacomo
Published: December 2023

This study examined how interruptions in insurance coverage affect purchases of prescription drugs for young adults. It used data spanning 2014 to 2018 from Kentucky’s prescription drug monitoring program, which tracked the universe of federally-regulated (Schedule II–V) prescription drugs dispensed in the state. The study employed a regression discontinuity design based on the age limit at 26 for dependent insurance coverage for children. At age 26, the probability of purchasing a prescription decreased by 5%, with all subcategories of prescriptions affected. The share of generic prescriptions increased for stimulants (the only category observed with substantial branded prescriptions). By age 27, prescription purchases returned to levels observed at 25, but the share purchased with public insurance and the generic share for stimulants remained higher. The findings suggest that interruptions in insurance coverage decrease prescription drug utilization by young adults and that public insurance programs such as Medicaid are important for resuming treatment.
Centering Health Equity Through the Social Determinants of Health, Interprofessional Education, and Sustainable Partnerships With Historically Black Colleges and Universities: Envisioning Upstream and Downstream Impacts
Authors: Holton Catherine , Banerjee Sri , Morgan Phyllis , McCune Nina M , Cook Amber , Thomas Jeani , Vesey Alyssa
Published: December 2023

The social determinants of health (SDOH) framework identifies barriers to health care, education, financial stability, and other conditions that exist across socially determined parameters, often to the detriment of Communities of Color. Postsecondary healthcare students must be aware of these disparities. In order to address upstream and downstream healthcare equity, the SDOH framework must be leveraged as a cross-disciplinary curricular innovation to support interprofessional education. Historically Black Colleges and Universities have unrealized potential to develop extraordinary healthcare leaders; partnerships integrating SDOH can be a powerful force to advance health equity in the United States.
The Spontaneous Incidence of Neurological Clinical Signs in Preclinical Species Using Cage-side Observations or High-definition Video Monitoring: A Retrospective Analysis
Authors: Orciani Chiara , Ballesteros Cristina , Troncy Eric , Berthome Clemence , Bujold Kim , Bennamoune Nehla , Sparapani Samantha , Pugsley Michael K. , Paquette Dominique , Boulay Emmanuel , Authier Simon
Published: December 2023

When conducting toxicology studies, the interpretation of drug-related neurological clinical signs such as convulsions, myoclonus/myoclonic jerks, tremors, ataxia, and salivation requires an understanding of the spontaneous incidence of those observations in commonly used laboratory animal species. The spontaneous incidence of central nervous system clinical signs in control animals from a single facility using cage-side observations or high definition video monitoring was retrospectively analyzed. Spontaneous convulsions were observed at low incidence in Beagle dogs and Sprague–Dawley rats but were not identified in cynomolgus monkeys and Göttingen minipigs. Spontaneous myoclonic jerks and muscle twitches were observed at low incidence in Beagle dogs, cynomolgus monkeys, and Sprague–Dawley rats but were not seen in Göttingen minipigs. Spontaneous ataxia/incoordination was identified in all species and generally with a higher incidence when using video monitoring. Salivation and tremors were the two most frequent spontaneous clinical signs and both were observed in all species. Data from the current study unveil potential limitations when using control data obtained from a single study for toxicology interpretation related to low incidence neurological clinical signs while providing historical control data from Beagle dogs, cynomolgus monkeys, Sprague–Dawley rats, and Göttingen minipigs.
Homoeopathic eye drops in the treatment of mild-to-moderate dry eye disease: Randomised, prospective, multicentre, single-masked study
Authors: Mortemousque B. , Pisella PJ. , Salaun N. , Lemaire N. , Chanel I.
Published: December 2023

Introduction

To compare the efficacy and safety of a homeopathic eye drop medicinal product (Homeoptic®) with 0.9% sodium hydrochloride eye drops (Larmabak®) in patients with mild-to-moderate dry eye disease (DED).

Methods

Prospective, single-masked, observer-blinded, multicentre study on adult patients. Non-inferiority primary endpoint of the relative change between treatment groups in a composite Visual Analogue Scale (VAS) score covering five symptoms of DED, namely pain, itching, sensation of dry eye, impression of foreign body presence and burning, after 30 days of treatment. Details of all Adverse Events (AEs) were recorded and analysed.

Results

Ninety three patients were randomised to each treatment arm. At Day 30, the mean VAS symptom score was 26.0 ± 18.8 in the Homeoptic® group and 32.8 ± 21.2 Larmabak® group. Homeoptic® was demonstrated to be non-inferior to Larmabak®: the mean treatment difference of −7 being below the 10 mm upper limit of the 95% CI ([-12.9; −1.0]) pre-set as significant. The superiority of Homeoptic® over Larmabak® was then established with detection of a significant difference between the two treatment groups (p = 0.022). Significant differences between the treatment groups in favour of Homeoptic® were also detected in isolated VAS scores for the symptoms dry eye sensation ( p = 0.009) and burning ( p = 0.004). Results of ocular surface staining tests to estimate corneal and conjunctival damage as well as patient satisfaction were also significantly in favour of Homeoptic®. No new safety concerns were identified.

Conclusion

Homeoptic® is more effective than Larmabak® at relieving the symptoms of DED and constitutes an effective treatment for mild-to-moderate DED.
Refractive lens exchange: What are the red lines?
Authors: Alio Jorge L. , Pederzolli Matteo , Grzybowski Andrzej
Published: December 2023

Practical advancements in phacoemulsification techniques and intraocular lenses and the wide availability of phacoemulsification machines have led refractive lens exchange (RLE) to increase in popularity. Ethical boundaries in RLE have subsequently been pushed to include patients at higher risk of complications. In this editorial, we consider RLE outcomes and complications per type of refractive error, together with preoperative, intraoperative and postoperative ethical obligations for refractive surgeons. In the conclusions section, we propose an algorithm for ethics-guided indications to RLE.
Place Branding Viewed From the Perspective of the Poetics of Space: The Case of Aesop’s Signature Stores
Authors: Kim Ji Eun , Park Eun Soo
Published: December 2023

This study argues for the aesthetics and values of a poetic space as a place branding strategy. Gaston Bachelard’s (1884–1962) poetic space refers to a happy place internalized by people, one where they can collectively achieve an aesthetic and emotional communion through imagination. Applying poetic space theory to place branding provides brand marketers with a powerful tool, as place branding offers an impression of the brand. This study thus seeks to explore place branding based on Bachelard’s poetic space theory presented in his book, The Poetics of Space, as a starting point for understanding space. Moreover, this study qualitatively examines the signature stores of Aesop to show that a place branded space that reflects the features of poetic space can create a positive image of the brand as a place of comfort and refuge. In addition, experiential elements allowing for natural internalization would help customers retain their positive associations with the brand in memory. Spatial expression methods of place branding that apply the features of poetic space as proposed by Bachelard serve as a substantial reference point for ideating concepts and directions for place branding.
Recruitment and retention of American Indian youth and caregivers in a culturally adapted prevention program
Authors: Rentschler Jamy K. , Behrendt Maia C. , Hoyt Dan R. , Whitbeck Les B.
Published: December 2023

This article seeks to understand to what extent cultural engagement and substance use risk factors influence families’ decisions to participate, and ultimately complete, a culturally grounded substance use prevention program. Using data from a 14-week culturally oriented family-based substance use prevention program, we examine predictors of successful recruitment and retention of American Indian youth and their caregivers. Guided by the theoretical model for developing culturally specific preventions, the community-based approach to recruitment resulted in 85.6% of eligible families from two American Indian communities agreeing to participate in the randomized controlled trial. After completion of baseline surveys, 57.3% of the intervention selected families initiated participation in the program sessions and 67.8% of these families completed participation in the program. We used logistic regression to analyze two different models: one that predicted whether invited families chose to participate and whether participating families attended eight or more sessions. Important predictors of participation in the intervention program included single-caregiver households, youth Indigenous language and cultural identity, youth early substance use initiation, and household substance use exposure. Overall, results from this study highlight the importance of fully engaged community research partnerships for multi-session family-based interventions, while identifying potential challenges to program recruitment and participation.
What is preventing private capital from reaching local climate action?
Authors: Hilburn Heather , Ronish Yarema
Published: December 2023

Private sector investable assets totalling USD 35.3 trillion globally are currently bound by at least one environmental, social and governance (ESG) criterion, 1 and could be targeted to deliver responses to the environmental crisis and subsequent devastating impact on vulnerable communities. However private sector finance for climate resilience and nature recovery is reported to be either moving very slowly, or not at all. 2 So what is the hold up? The co-founders of Biodiversity Capital have a longstanding combined history of delivering projects in urban regeneration, as well as green 3 and blue 4 infrastructure, housing and culture across the private and public sector, where financing for projects follows a linear start to finish model with handover to the client on completion. Since the beginning of the 20th century, charities have received funding from either government or philanthropists to deliver programmes against an agreed set of quantifiable targets and outputs. The current crisis on our hands is not static, it is a mix of complex, intertwined social, economic and environmental factors, where long-term stewardship, ultimately unique and very local, is now deemed a fundamental part of the equation from the start. In the light of this, we argue that achieving climate justice will require private finance to embrace the distinctive nature of collaboration between governments and the non-profit sector.
Predictive power of isolated high home systolic blood pressure for cardiovascular outcomes in individuals with type 2 diabetes mellitus: KAMOGAWA-HBP study
Authors: Hosomi Yukako , Ushigome Emi , Kitagawa Nobuko , Kitagawa Noriyuki , Tanaka Toru , Hasegawa Goji , Ohnishi Masayoshi , Tsunoda Sei , Ushigome Hidetaka , Nakamura Naoto , Asano Mai , Hamaguchi Masahide , Yamazaki Masahiro , Fukui Michiaki
Published: December 2023

Aims/Introduction

Isolated high home systolic blood pressure (IHHSBP) is a risk for cardiovascular disease (CVD). However, no study has shown an association between IHHSBP and CVD in diabetes. We examined the association between IHHSBP and CVD in type 2 diabetes.

Materials and Methods

This retrospective cohort study included 1082 individuals with type 2 diabetes, aged 20 to 90 years, without a history of macrovascular complications. Home blood pressure (HBP) was measured three times every morning and evening for 14 days. Cox proportional hazards models were used to examine the relationship between IHHSBP and CVD incidence.

Results

With the normal HBP group as the reference, the adjusted hazard ratio (HR) (95% confidence interval [CI]) for CVD was 1.58 (1.02–2.43) in the IHHSBP group. Correcting for antihypertensive medication use did not change HR. Based on sex, the adjusted HR (95% CI) for CVD was 1.25 (0.74–2.13) in males and 2.28 (1.01–5.15) in females.

Conclusions

In individuals with type 2 diabetes, those with IHHSBP had a higher HR for cardiovascular disease than those with normal HBP. But, Isolated high home diastolic blood pressure and high HBP were not. The association between IHHSBP and CVD was stronger in females than in males.
Comorbid Factors and Selection for Same-Day Total Joint Arthroplasty
Authors: Russell Linda A.
Published: December 2023

Given that the number of total joint arthroplasties (TJAs) performed worldwide is expected to continue to increase, and there are significant costs associated with these procedures, selecting candidates for same-day or 23-hour discharge is important in lowering costs and providing greater access. Younger, healthier patients are excellent candidates for same-day discharge after TJA. Preoperative medical assessment can help exclude patients who may not be candidates, such as patients with 1 or more comorbidities that increase the risk of intra- and postoperative complications and who may require a longer period of monitoring
Coupled vibration characteristics of marine shafting with complex change of inclination under ice loads
Authors: Dong Liangxiong , Li Jubao
Published: December 2023

With the intensifying exploitation of the resources and the waterway of the Arctic region in worldwide, the variable inclination propulsion system are gradually used in the ice-sailing ship, its design and strength study are of great engineering significance and application value. A variable inclination propulsion shafting with universal joint is introduced and its mechanical model is established in this paper. By combine torsional stress and inclination angle calculation, a decoupling algorithm based on Newmark is designed, and then the analysis of ice loads response in both frequency domain and time domain are completed. The results show that due to the complex triangle function relation among the various components of the shafting, there is an interaction between the propeller and the transmission shafting. In particular, when considering the dynamic change of inclination, nonlinear bending-torsional coupling vibration may occur and further lead to the enhancement effect of torsional vibration. Among the three working conditions defined by DNV, the bending-torsional coupling effect vary with rotation speed and inclination angle, and is mainly concentrated in high frequency bands. In the ice loads condition 2, with the largest time domain excitation amplitude and the smallest high order component, it’s vibration response is the strongest, and the change law of dangerous phase angle is similar to the bending moment. With the increase of initial inclination angle, the amplitude of low frequency vibration decreases, yet the amplitude of high frequency vibration increase. This trend is more obvious with the increase of rotation speed, and more high frequency resonance points appear in the condition 1 and condition 3.
Renal and ureteric colic
Authors: Agata Berezowska Aleksandra , Nikolinakos Panagiotis
Published: December 2023

Renal and ureteric colic describes acute onset, severe flank pain. It is caused by an obstruction within the renal collecting system or ureter and is primarily precipitated by stones. In this article, our aim is to discuss the etiology of renal colic, its management in primary care, and indications for secondary care referral. We will also discuss risk factors for stone formation and the available prevention advice.
Prevalence and Predictors of Subclinical Cardiomyopathy in Patients With Type 2 Diabetes in a Health System
Authors: Nagori Aditya , Segar Matthew W. , Keshvani Neil , Patel Lajjaben , Patel Kershaw V. , Chandra Alvin , Willett DuWayne , Pandey Ambarish
Published: December 2023

Introduction:

Diabetic cardiomyopathy (DbCM) is characterized by subclinical abnormalities in cardiac structure/function and is associated with a higher risk of overt heart failure (HF). However, there are limited data on optimal strategies to identify individuals with DbCM in contemporary health systems. The aim of this study was to evaluate the prevalence of DbCM in a health system using existing data from the electronic health record (EHR).

Methods:

Adult patients with type 2 diabetes mellitus free of cardiovascular disease (CVD) with available data on HF risk in a single-center EHR were included. The presence of DbCM was defined using different definitions: (1) least restrictive: ≥1 echocardiographic abnormality (left atrial enlargement, left ventricle hypertrophy, diastolic dysfunction); (2) intermediate restrictive: ≥2 echocardiographic abnormalities; (3) most restrictive: 3 echocardiographic abnormalities. DbCM prevalence was compared across age, sex, race, and ethnicity-based subgroups, with differences assessed using the chi-squared test. Adjusted logistic regression models were constructed to evaluate significant predictors of DbCM.

Results:

Among 1921 individuals with type 2 diabetes mellitus, the prevalence of DbCM in the overall cohort was 8.7% and 64.4% in the most and least restrictive definitions, respectively. Across all definitions, older age and Hispanic ethnicity were associated with a higher proportion of DbCM. Females had a higher prevalence than males only in the most restrictive definition. In multivariable-adjusted logistic regression, higher systolic blood pressure, higher creatinine, and longer QRS duration were associated with a higher risk of DbCM across all definitions.

Conclusions:

In this single-center, EHR cohort, the prevalence of DbCM varies from 9% to 64%, with a higher prevalence with older age and Hispanic ethnicity.
A cross-sectional assessment of burnout presence among pharmacy professionals at Kathmandu Valley, Nepal
Authors: Ranabhat Rama , Giri Anil , Sapkota Binaya , Shrestha Rajeev , Shrestha Sunil
Published: December 2023

Introduction:

Burnout is a significant concern among healthcare professionals, including pharmacists, as it can lead to adverse effects on their well-being, job satisfaction, and patient care delivery. However, no previous study was conducted among pharmacy professionals in Nepal to assess their burnout cases. This study aimed to evaluate burnout presence and explore its associated factors among pharmacy professionals in Nepal.

Methods:

A cross-sectional study was conducted among pharmacy professionals of Kathmandu Valley, Nepal. The validated Burnout Assessment Tool measured burnout across multiple domains. Data on demographic and work-related characteristics were also collected. Descriptive statistics and Chi-square tests were used to analyze the data and identify significant associations among the variables.

Results:

Most participants were in the age group of 21–30 (64.7%), had a graduate degree (47.3%), and worked in hospital pharmacy settings (49.1%). Exhaustion was the most common (39.7%) burnout experienced, while mental distance and emotional and cognitive impairment were reported in one-fourth of the participants. Alternatively, only one in five participants showed secondary symptoms of burnout. Gender, working hours, exercise frequency, and substance abuse were significantly associated with burnout domains.

Conclusion:

This study provides valuable insights into the prevalence and factors associated with burnout among pharmacy professionals in Nepal. The findings highlight the significance of addressing burnout in this crucial healthcare sector, with gender, exercise frequency, and substance use emerging as notable contributors. These results underscore the need for targeted interventions and support systems to promote the well-being of pharmacy professionals and ensure the continued delivery of high-quality healthcare services in Nepal.
The impact of the COVID-19 pandemic on early termination of ophthalmology clinical trials: A cross-sectional analysis of ClinicalTrials.gov
Authors: Kakkilaya Akash , Hooda Karan , Kalva Praneeth , Dasara Harshith , Janssen Christopher , Vasireddy Satvik , Ahmed Arbab , Khan Salman , Kooner Karanjit
Published: December 2023

Objective:

To study the effect of the COVID-19 pandemic on the early termination of ophthalmology clinical trials.

Methods:

On June 10, 2022, we searched ClinicalTrials.gov and identified clinical trials pertaining to eye diseases. We included trials last updated between January 1, 2020 and June 8, 2022, as ones possibly impacted by the pandemic. We selected all interventional trials in any stage and country that were “recruiting,” “active, not recruiting,” “enrolling by invitation,” “suspended,” “terminated,” “completed,” or “withdrawn” and excluded trials that had been completed or discontinued before 2020, had incomplete data, trials in which the eye was not the primary focus of the trial (e.g., Chediak-Higashi syndrome, myasthenia gravis). The following trial-level characteristics were collected: location, trial status, enrollment count, ocular condition, sponsors, intervention purpose, trial phase (I–IV), randomization, number of arms, and reasons for discontinuation. In addition to calculating descriptive statistics, we assessed whether trial characteristics differed between ophthalmology clinical trials canceled due to COVID-19 and those canceled for other reasons.

Results:

Following the screening, 2280/12,679 (18%) ophthalmology clinical trials were retained. Of these, 142 (6.2%) were discontinued between January 1, 2020 and June 8, 2022. Moreover, 34 out of 142 (23.9%) ophthalmology clinical trials were discontinued due to COVID-19. These trials were more likely to be sponsored by academic medical centers (26/34, 76.5% vs 57/108, 52.8%, p = 0.03) and were not assigned to a specific study phase, indicating they were not investigational new drugs (22/34, 64.7% vs 46/108 42.6%, p = 0.003).

Conclusions:

COVID-19-related trial discontinuations were more likely to be reported by academic medical centers and associated with trials investigating fully approved drugs, medical devices, procedures, diagnostic imaging, and behavioral changes. Further investigation of these characteristics may lead to a more robust and resilient understanding of the causes of early termination of these clinical trials.
Reconstituting digital counterpublics in times of crisis: The case of the United States and the Republic of Georgia
Authors: Craig Byron B , Rahko Stephen E. , Carpenter Nathan
Published: December 2023

Since the advent of social media at the turn of the 21st century, scholars of communication, cultural studies, and media studies have long been invested in the question of the relationship between social media platforms and the discursive formation of counterpublics for social movement mobilization. In this article, we seek to pose a new question for scholarly inquiry: How do citizens leverage the tools of social media platforms to reconstitute counterpublics in times of crisis? Toward this end, we conduct a comparative case study of the way citizens leverage platforms for counterpublic formation in the Republic of Georgia and the United States. Both cases represent two ends of the Janus-face of the 21st-century Internet: The Internet as a tool for public will-formation that can enrich the flowering of democracy across digital spaces, and the Internet as a tool capable of undermining traditional norms of public will formation predicated on shared understanding across the public sphere(s).
How Does Self-Efficacy in Communication Affect the Relationship Between Intercultural Experience, Language Skills, and Cultural Intelligence
Authors: Jurasek Miroslav , Wawrosz Petr
Published: December 2023

Cultural intelligence (CQ) is a multidimensional socio-mental construct that allows a person to effectively explore and understand different cultures for the benefit of the entire organization. Therefore, many studies investigate which factors support or hinder CQ development. Our study anticipates that intercultural social contracts, travel experience and knowledge of foreign languages affect CQ. We further explore how these direct relationships are mediated by the variables of self-efficacy in communication. To confirm or reject our hypotheses we used a sample ( n = 190) of university students studying at a private Czech university and a public Russian university that is analyzed using the statistical technique PLS-SEM. Our results confirm that intercultural social contacts, the experience of traveling abroad, and knowledge of foreign languages are positively related to CQ, and that self-efficacy partially positively mediates these relations. The study can serve as the base for other research concentrating on the mediators of the factors supporting CQ.
Developing and Evaluating an Online Professional Development Model on Academic Writing Conventions and Norms in English
Authors: Kaya Fatma , Yağız Oktay
Published: December 2023

This study aimed to determine non-native speakers of English academics’ knowledge and awareness of conventions and norms of academic writing (AW), to develop an online professional development model addressing all disciplines, and to evaluate the effect of this model on their AW performances with their views on the model. The study was based on the mixed methods evaluation design. The participants were nine academics in educational and social sciences at a state university in Turkey. An online professional development model encompassing eight themes related to AW was developed. Data were collected through pre- and post-tutorial semi-structured interviews and writing tasks. Textual and content analyses were used for the qualitative data, and the Wilcoxon Signed Rank Test was performed for quantitative analysis. The results showed that before the tutoring, the participants acknowledged various difficulties regarding AW conventions and norms. The data after the online asynchronous tutoring showed that explicit instruction increased the participants’ knowledge and awareness, and the proposed model contributed to their writing performances, and promoted their AW skills. However, participants’ hedging use was found limited to modal verbs use. Paraphrasing tasks also showed significant differences between before and after tutoring writing tasks. Participants highlighted the importance of long-term implementational writing instruction.
The Fear of Falling, Physical Activity, and Quality of Life in Elderly After COVID-19
Authors: Göktaş Ayşe , İnal Özgü , Özkan Esma , Özdinç Sevgi
Published: December 2023

The COVID-19 negatively affected the physical and mental health of elderly due to pandemic-related restrictions. This study aimed to investigate the influences on fear of falling, physical activity level, and quality of life in older people living in the community after the COVID-19. Falls Efficacy Scale-International (FES-I), Physical Activity Scale for the Elderly (PASE), and Nottingham Health Profile (NHP) were used to study. One hundred fifty individuals older than 65 years. Results indicated that 69.3% of the individuals had fallen in the past 6 months. FES-I showed that the elderly had moderate FES-I (31.95 ± 10.55), and PASE showed that this cohort had severe activity limitation (85.42 ± 56.45) and low NHP (213.62 ± 143.45). There was negative association between FES-I and PASE levels (ρ = .000, r = −0.291) and a moderate negative association between. FES-I and NHP (ρ = .000, r = 0.577). The variables for the number of falls and FES-I were included in the multiple linear regression analysis and model formed with FES-I that predicted PASE level was statistically significant. As a result, it is important to raise awareness about older individuals’ concerns regarding falling to implement essential measures that can effectively alleviate such fears.. In this context, it is advisable to explore innovative clinical and policy strategies that can facilitate the seamless integration of interdisciplinary preventive care for vulnerable elderly individuals, with the overarching aim of enhancing their overall quality of life.
The Effects of Post-Encoding Emotion on Second Language Vocabulary Learning
Authors: Li Yi , Wang Xinpeng
Published: December 2023

There is evidence that emotion induced in the process of encoding impairs associative memory, yet the effect of post-encoding emotion on second language vocabulary learning remains largely unclear. An experiment was carried out to examine the effects of post-encoding emotion (positive, negative, and neutral) on learning of multidimensional vocabulary knowledge, that is, productive and receptive vocabulary knowledge in five aspects: orthography, meaning and form, grammatical function, syntagmatic association, and paradigmatic association. To carry out the study, 106 Chinese students voluntarily took part in the present study and they were randomly divided into positive group, negative group, and control group. After completing the vocabulary learning task and undergoing emotion manipulation by three video clips (positive, negative, and neutral), all participants sequentially took a multidimensional vocabulary test containing 10 subtests in a immediate, delayed, and post-delayed tests. The result showed a significant impairing effect of post-encoding emotion, especially positive one, on both item memory and associative memory under a longer retention interval, and no significant effect of post-encoding emotion upon semantic memory was found. Both theoretical and practical implications for second language vocabulary learning was put forward.
The Association Between Autonomy Need Satisfaction and Perceived Romantic Relationship Quality: The Mediating Role of Openness
Authors: Oz-Soysal F. Selda , Bakalım Orkide , Tasdelen-Karckay Arzu , Ogan Samiye
Published: December 2023

One of the most critical developmental tasks during the university years is to develop close romantic relationships. The quality of the relationship established is as important as the existence of these relationships. In this study, a model that examines the mediating role of openness in the association of autonomy need satisfaction and perceived romantic relationship quality among emerging adults was tested. The study group consisted of 510 university students. A personal information form, the Fulfillment Scale of the Needs in Romantic Relationships, the Relationship Maintenance Strategies Scale, and the Perceived Romantic Relationship Quality Scale were used to collect data. The initial analyses showed that there were positive and significant correlations between autonomy needs satisfaction, openness, and perceived relationship quality. In addition, the emerging adults whose autonomy needs were met were more open in their close relationships and, as a result, had a higher level of perceived romantic relationship quality.
Anatomic Assessment of L1-S1 Neuroforaminal Dimensions Using Computed Tomography in 1,000 Patients: A Follow-Up Study
Authors: Nguyen Kai , Razzouk Jacob , Brandt Zachary , Carlson Patricia , Vyhmeister Ethan , Bouterse Alex , Wycliffe Nathaniel , Cheng Wayne , Danisa Olumide
Published: December 2023

Objectives

While the radiographic criteria for diagnosing central lumbar stenosis are well described, criteria for diagnosing neuroforaminal stenosis (NFS) are unclear. Prior research has utilized magnetic resonance imaging (MRI) to characterize neuroforaminal dimensions (NFDs). However, this approach has inherent limitations that can adversely impact measurement accuracy. Existing literature on the use of computed tomography (CT) to investigate normal NFDs is limited. The purpose of the present study was to describe normal lumbar NFDs that would aid in the establishment of objective quantitative criteria for the diagnosis of NFS.

Methods

This study evaluated CT imaging of 494 female and 506 male subjects between 18 and 35 years of age to determine normal NFDs, specifically the sagittal anteroposterior width, craniocaudal height, and area. Statistical analyses were performed to assess differences in NFDs according to variables including sex, height, weight, body mass index, and ethnicity.

Results

Without differentiating between sides or disc levels, mean NFDs were 8.71 mm for sagittal anteroposterior width, 17.73 mm for craniocaudal height, and 133.26 mm2 for area (n = 10,000 measurements each). Male subjects had larger NFDs than females at multiple levels. Asian and Caucasian subjects had larger NFDs than Hispanic and African American subjects at multiple levels. There were no associations between NFDs and anthropometric factors.

Conclusions

The present study describes normal lumbar NFDs in young, healthy patients. NFDs were influenced by sex and ethnicity but not by anthropometric factors.
Comparison of 2 Anesthetic Methods for Transforaminal Endoscopic Lumbar Discectomy: A Prospective Randomized Controlled Study
Authors: Wang Shuang , Zheng Liang , Ma Jun-xiong , Wang Hong , Wang Kai-qiang , Chen Yu , Yu Hai-long , Xiang Liang-bi
Published: December 2023

Study Design

Randomized controlled trial.

Objectives

To compare the effect and safety of 2 anesthetic methods using in the operation of Transforaminal Endoscopic Lumbar Discectomy.

Methods

From the January of 2020 to the December of 2021, 230 consecutive patients that underwent TELD were applied with two methods of anesthesia. All the patients were divided into two groups. The Monitored Anesthesia Care (MAC) group used the local anesthesia (LA) with MAC that based on the combination of dexmedetomidine and butorphanol tartrate. The LA group used the local anesthesia only. Then the Visual Analogic Scale (VAS) through the operating period was compared between the two groups at the time points of before operation (T0), inserting of the puncture needle (T1), establishing of the working cannula (T2), excision of the fibrous rings (T3) and immediately postoperatively (T4). Also, the satisfaction degree of the patients for the course of the operations and the occurrence of the complications were compared between the two groups.

Results

There were no differences of the VAS around the operating area at the time point of T0. Then the MAC group expressed lower scores at all other points of T1, T2, T3 and T4. Then the satisfaction degree of the MAC group was superior than the LA group. No difference was observed for the occurrence of the complications.

Conclusions

MAC based on the combination of dexmedetomidine and butorphanol tartrate is an ideal method of anesthesia for TELD with enough effect and safety.
Evolvable case-based design: An artificial intelligence system for urban form generation with specific indicators
Authors: Liu Yubo , Hu Kai , Deng Qiaoming
Published: December 2023

This research proposes a design system that combines a case-based learning algorithm with a rule-based optimization algorithm to automatically generate and revise urban form prototypes based on historical cases and user requirements. The system aims to address the challenges of existing generative methods for urban forms, such as the lack of flexibility and organicity of rule-based methods and the insufficient manipulability and interpretability of the newest GAN-integrated case-based methods. It can help designers generate multiple solutions with specific indicators in the conceptual stage and has the potential to facilitate citizen participation in urban planning and design. This research demonstrates the feasibility and effectiveness of the system through a case study in Shenzhen. The research further extends the discussion about the application of the proposed system and the alternative evolution approach for the next generation of automatic design methods.
Early Outcomes Following Plantar Condylectomy and Imbrication of Plantar Plate to Metatarsal Neck for Metatarsalgia and Grade 0 Lesser Toe Metatarsophalangeal Joint Instability
Authors: Kent Robert N. , Walley Kempland C. , Saunders Noah , Colomb Eric , Patel Vandan , Holmes James R. , Walton David M. , Talusan Paul G.
Published: December 2023

Background:

Metatarsalgia and plantar plate tears are characterized by forefoot pain and toe deformity in severe cases. Conservative management may slow progression of symptoms; however, definitive treatment often requires operative intervention. The purpose of this observational study was to evaluate the combination of plantar condylectomy and surgical imbrication of the plantar plate to the metatarsal neck to repair grade 0 plantar plate injuries.

Methods:

We retrospectively identified 22 patients with metatarsalgia and low-grade plantar plate lesions (grade 0), operated between 2018 and 2021, who underwent operative repair involving plantar metatarsal condylectomy and proximal surgical imbrication of the plantar plate to the metatarsal neck. Fourteen patients underwent concomitant hallux valgus correction. Data collection was performed preoperatively and postoperatively and included Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) and pain interference (PI) scores. Paired Wilcoxon signed-rank tests compared PROMIS PF and PI scores at patients’ preoperative, 6-9-week, 3-4-month, 5-6-month, and ≥9-month follow-up evaluations ( P < .05).

Results:

Compared to their preoperative visit, patients demonstrated modest improvement in their PROMIS (pain and physical function) scores over the first ≥9 months postoperatively (median 13.0 months). Median preoperative and most recent PROMIS physical function scores were 40.5 (95% CI: 36-49) and 44.5 (95% CI: 40-52), respectively. Median PROMIS pain interference scores changed from 62.5 (95% CI: 56-67) to 56.0 (95% CI: 51-62). Improvement in pain and function was sustained in patients available for postoperative follow-up.

Conclusion:

In this small, early follow-up series, we found that plantar condylectomy and surgical imbrication of the plantar plate to the metatarsal neck was modestly helpful to treat metatarsalgia and grade 0 plantar plate injuries.

Level of Evidence:

Level IV, retrospective case series.
Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022
Authors: Baumgartner Francis , Baer Constance , Bamopoulos Stefanos , Ayoub Edward , Truger Marietta , Meggendorfer Manja , Lenk Miriam , Hoermann Gregor , Hutter Stephan , Müller Heiko , Walter Wencke , Müller Martha-Lena , Nadarajah Niroshan , Blombery Piers , Keller Ulrich , Kern Wolfgang , Haferlach Claudia , Haferlach Torsten
Published: December 2023

The World Health Organization (WHO) classification of hematolymphoid tumors and the International Consensus Classification (ICC) of 2022 introduced major changes to the definition of chronic myelomonocytic leukemia (CMML). To assess its qualitative and quantitative implications for patient care, we started with 3311 established CMML cases (according to WHO 2017 criteria) and included 2130 oligomonocytosis cases fulfilling the new CMML diagnostic criteria. Applying both 2022 classification systems, 356 and 241 of oligomonocytosis cases were newly classified as myelodysplastic (MD)-CMML (WHO and ICC 2022, respectively), most of which were diagnosed as myelodysplastic syndrome (MDS) according to the WHO 2017 classification. Importantly, 1.5 times more oligomonocytosis cases were classified as CMML according to WHO 2022 than based on ICC, because of different diagnostic criteria. Genetic analyses of the newly classified CMML cases showed a distinct mutational profile with strong enrichment of MDS-typical alterations, resulting in a transcriptional subgroup separated from established MD and myeloproliferative CMML. Despite a different cytogenetic, molecular, immunophenotypic, and transcriptional landscape, no differences in overall survival were found between newly classified and established MD-CMML cases. To the best of our knowledge, this study represents the most comprehensive analysis of routine CMML cases to date, both in terms of clinical characterization and transcriptomic analysis, placing newly classified CMML cases on a disease continuum between MDS and previously established CMML.
Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia
Authors: Yang Zijing , Hu Liang , Zhen Jianxin , Gu Yuqin , Liu Yanhong , Huang Shang , Wei Yuandan , Zheng Hao , Guo Xinxin , Chen Guo-Bo , Yang Yan , Xiong Likuan , Wei Fengxiang , Liu Siyang
Published: December 2023

Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women being diagnosed with gestational thrombocytopenia (GT), characterized by a more marked decrease in platelet count during pregnancy. However, the underlying biological mechanism behind these phenomena remains unclear. Here, we used sequencing data from noninvasive prenatal testing of 100 186 Chinese pregnant individuals and conducted, to our knowledge, the hitherto largest-scale genome-wide association studies on platelet counts during 5 periods of pregnancy (the first, second, and third trimesters, delivery, and the postpartum period) as well as 2 GT statuses (GT platelet count < 150 × 109/L and severe GT platelet count < 100 × 109/L). Our analysis revealed 138 genome-wide significant loci, explaining 10.4% to 12.1% of the observed variation. Interestingly, we identified previously unknown changes in genetic effects on platelet counts during pregnancy for variants present in PEAR1 and CBL, with PEAR1 variants specifically associated with a faster decline in platelet counts. Furthermore, we found that variants present in PEAR1 and TUBB1 increased susceptibility to GT and severe GT. Our study provides insight into the genetic basis of platelet counts and GT in pregnancy, highlighting the critical role of PEAR1 in decreasing platelet counts during pregnancy and the occurrence of GT. Those with pregnancies carrying specific variants associated with declining platelet counts may experience a more pronounced decrease, thereby elevating the risk of GT. These findings lay the groundwork for further investigation into the biological mechanisms and causal implications of GT.