bluuebunny/crossref_metadata_2025 huggingface dataset:
Kenopak Lamaholot: Menemukan Makna Religius-Etis dan Didaktis Ungkapan Bijak Masyarakat Tanalein
Authors: Toron Yosef Masan
Published: July 2023

Kenopak, in the literary perspective can be compared with the “wisdomgenre”, found among the Lamaholot people, who live in the easternpart of Flores. Most people use the “Lamaholot” language as the spokenlanguage. Lamaholot language can be used in different ways, eitherordinary or extraordinary. Kenopak is always used in extraordinarytimes, for ritual needs or different cultural events. Using “kenopak”,the Lamaholot people try to describe the history and the role of theclan in certain social contexts, the existence of the High Being, andmany different values in different fields of life. Being conscious of theimportant values of kenopak, this study is trying to find different valuesof kenopak among the people in Tanalein, West Solor, Larantuka, andcomparing them with the values of wisdom in the Bible Tradition.Kenopak as the wisdom expression among the Lamaholot people isnot only a range of words and sentences without meaning, inheritedfrom the old generations. After doing a long research and analyzing itscontents, kenopak actually have different important values for life. Ethic,religious and didactics are the basic and fundamental values that can’tbe separated from different kenopak, that are known and acknowledgedamong the Lamaholot people. Those values have a close relation withthe basic christian values found in the Bible. Facing the changes and thedevelopment of times, those values might be useful for the formation ofyoung generations, preparing them as the generation for future.
Partisipasi Kaum Awam Dalam Bidang Politik Menurut Dekrit Konsili Vatikan Ii Apostolicam Actuositatem
Authors: Jehaut Rikardus
Published: July 2023

Since the Second Vatican Council, the emphasis on the dignity and the role of the laity in the Church and society has been one of the important developments in ecclesiology. And given to the fact that it is proper to the laity ’s state to live both in the midst of the world and of secular transactions, the typical mark or special characteristic of the laity ’s participation in the mission of the Church is an apostolate exercised in and through direct concern with secular affairs, particularly in politics. In this regard, the decree Apostolicam Actuositatem, particularly in articles 7 and 14 has inspired the laity by stating that Catholics versed in politics, firm in the faith and Christian teaching, should not decline to enter public life.This article will examine - in the light of the teaching of the decree - how Catholic lay members can contribute to promoting the common good through their participationin politics. And in order to fully realize the mission of the laity in politics, there is need for lay formation and authentic collaboration between the clergy and the laity. It will also demonstrate how an effective transformation of the laity can be achieved through their socialization in the social teaching of the Church with regard to how they can contribute to the promotion, protection, and preservation of the common good.
Memahami Teori Inteligensi Ganda Howard Gardner Dan Aplikasinya Dalam Proses Pembelajaran Di Sekolah Dewasa Ini
Authors: Haru Emanuel
Published: July 2023

Howard Gardner is well-known because of his multiple intelligences theory. According to him, there are many kinds of intelligences. At least, there are nine kinds of intelligences. And all these intelligences owned by everyone with different grade/ quality. Commonly, people proud when his/ her intelligence quotient (IQ) is high. And people think that the high intelligence quotient (IQ) is the main guarantee to reach the successful. Actually, one’s successful not only determined by intelligence quotient (IQ), but by all these intelligences. In this case, we must know what benefit of knowing the various intelligences in ourselves. Especially, it is important for a teacher to know all kinds of intelligences in his/ her students. Thus, in learning process, a teacher not only pay attention to a certain intelligence (such as intelligence quotient), but he/ she also has to pay attention to many kinds of intelligences. By this way, a teacher accomodate all students in exploring their capabilities.
Kuasa Mengajar Sebagai Pelayanan Seorang Uskup
Authors: Tolo Paulus
Published: July 2023

Teaching authority in Roman Catholic is entrusted to apostolic college of bishops with Pope as its head. This authoriy has been developed from the ouset of christianism. It is believed that the the apostolic college has handed over to bishops as their successor. The teaching authority performed by bishop is restricted to faith and moral matter. Their teachings in these matters obtain an infallible character. As far as the faith and moral matter are concerned, the infallibel character is accepted. Issues regarding politics, economics and so on are not in domain of the teaching authority of Magisterium. Catholics are strongly recommended to give their obbedience to the teachings of Magisterium. Are there possibilities to dissent from these teachings? This article demonstrates historical development of teaching authority in roman catholic and its implementation.
Narasi Kandang: Dari Betlehem Menuju Manusia Baru Menggagas Spiritualitas Kelahiran Baru Para Religius Menurut Lukas 2:1-7
Authors: Toron Yosef Masan
Published: July 2023

We have been recently celebrating the Christmas. The Christmas among chirstians is aways regarded as the memorial celebration of the birth of Jesus, the Messiah, as the fulfillment of the prophesy of prophets in the past. The most interesting symbols found during this moment are the cave and the shepherds. Jesus, the Messiah, has chosen the cave, the most simple place as the “locus” of His birth. This choice is really an ironic panorama. The Most High, the King of the kings has made the cave and the stable to be the “locus of revelation”, the place where the High Being reveals Himself to the world. From the beginning, the Savior introduces Himself as the Most Poor among poors. Using this image, God is going to show clearly His choice and fundamental option to human being. There’s no highway to be Savior, except to follow the stoney way on the country-side. The simple narative story of Jesus’ birth in Bethlehem remind all chirstians about the value of poverty and simplicity of our human being. We are called back to our humanity, to our own Beth-lehem, our natural roots, to be aware of our own strenghts and weaknesses as the starting-point of our journey proceeding to the fullness of our dignity and our salvation. The Christmas is not only an annual liturgical celebration but also a symbolic action, inviting us back home, making us aware of our existence as human being. Christ has chosen the poverty as the “hodos”, the best way leading all human being to the fullness of salvation.
Experimental and numerical study on the dry/wet burst failure of reinforced thermoplastic pipes
Authors: Liu Wencheng , Ding Xindong , Wang Shuqing , Xu Mingqiang
Published: July 2023

This paper investigates the burst failure of reinforced thermoplastic pipes (RTPs) via combined experimental and numerical research. Two completely different burst forms appeared during the experiments. The dry burst form occurs with matrix cracks, fiber breakage and crack of liner and coating, which is a common burst morphology. A new burst morphology, which is never reported in open literature, is observed in the experiments. This burst morphology, defined as wet burst form, presents a long dent in the coating and invisible composite damage. In order to simulate the burst failure of RTPs, a numerical model was proposed, in which element removal criteria and the nonlinear stiffness degradation model based on Hashin‐Yeh failure criterion were employed to conduct progressive failure analysis on 3D composites. It was found that the wet burst form has lower burst pressure and causes larger damaged area, which is more dangerous in engineering. For the damage propagation, progressive failure occurs on middle composites and induces the final burst when the dry burst form occurs. As for the wet burst form, water flows into the middle of RTPs, which causes the delamination, matrix crack and bulge of coating. During the process, fibers play few roles in bearing loads.

Highlights

The wet burst form of reinforced thermoplastic pipes is firstly observed.

Element removal criteria and nonlinear stiffness degradation model were used to simulate the burst failure.

The numerical model has a good performance on predicting the burst pressure and damage propagation of composites.

The wet burst form has lower burst pressure compared with the dry burst form.

Fiber and matrix tensile failure mode are dominant.
Conformationally constrained cyclic grafted peptidomimetics targeting protein–protein interactions
Authors: Dahal Achyut , Subramanian Vivekanandan , Shrestha Prajesh , Liu Dong , Gauthier Ted , Jois Seetharama
Published: July 2023

Sunflower trypsin inhibitor‐1 (SFTI‐1) structure is used for designing‐grafted peptides as a possible therapeutic agent. The grafted peptide exhibits multiple conformations in solution due to the presence of proline in the structure of the peptide. To lock the grafted peptide into a major conformation in solution, a dibenzofuran moiety (DBF) was incorporated in the peptide backbone structure, replacing the Pro‐Pro sequence. NMR studies indicated a major conformation of the grafted peptide in solution. Detailed structural studies suggested that SFTI‐DBF adopts a twisted beta‐strand structure in solution. The surface plasmon resonance analysis showed that SFTI‐DBF binds to CD58 protein. A model for the protein‐SFTI‐DBF complex was proposed based on docking studies. These studies suggested that SFTI‐1 grafted peptide can be used to design stable peptides for therapeutic purposes by grafting organic functional groups and amino acids. However, when a similar strategy was used with another grafted peptide, the resulting peptide did not produce a single major conformation, and its biological activity was lost. Thus, conformational constraints depend on the sequence of amino acids used for SFTI‐1 grafting.
Multiparametric MRI radiomics in prostate cancer for predicting Ki-67 expression and Gleason score: a multicenter retrospective study
Authors: Zhou Chuan , Zhang Yun-Feng , Guo Sheng , Wang Dong , Lv Hao-Xuan , Qiao Xiao-Ni , Wang Rong , Chang De-Hui , Zhao Li-Ming , Zhou Feng-Hai
Published: July 2023

Purpose

Prostate cancer (PCa) with high Ki-67 expression and high Gleason Scores (GS) tends to have aggressive clinicopathological characteristics and a dismal prognosis. In order to predict the Ki-67 expression status and the GS in PCa, we sought to construct and verify MRI-based radiomics signatures.

Methods and materials

We collected T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) images from 170 PCa patients at three institutions and extracted 321 original radiomic features from each image modality. We used support vector machine (SVM) and least absolute shrinkage and selection operator (LASSO) logistic regression to select the most informative radiomic features and built predictive models using up sampling and feature selection techniques. Using receiver operating characteristic (ROC) analysis, the discriminating power of this feature was determined. Subsequent decision curve analysis (DCA) assessed the clinical utility of the radiomic features. The Kaplan–Meier (KM) test revealed that the radiomics-predicted Ki-67 expression status and GS were prognostic factors for PCa survival.

Result

The hypothesized radiomics signature, which included 15 and 9 selected radiomics features, respectively, was significantly correlated with pathological Ki-67 and GS outcomes in both the training and validation datasets. Areas under the curve (AUC) for the developed model were 0.813 (95% CI 0.681,0.930) and 0.793 (95% CI 0.621, 0.929) for the training and validation datasets, respectively, demonstrating discrimination and calibration performance. The model's clinical usefulness was verified using DCA. In both the training and validation sets, high Ki-67 expression and high GS predicted by radiomics using SVM models were substantially linked with poor overall survival (OS).

Conclusions

Both Ki-67 expression status and high GS correlate with PCa patient survival outcomes; therefore, the ability of the SVM classifier-based model to estimate Ki-67 expression status and the Lasso classifier-based model to assess high GS may enhance clinical decision-making.
Simulate Your True Self
Authors: Leuenberger Muriel
Published: July 2023

That the world we seem to experience around us might be nothing but a simulation – perhaps generated by a demon or super-computer – is a perennial theme in science fiction movies. Muriel Leuenberger explores a recent example.
Escaping the Modern Caves
Authors: Read Rupert , Eastoe Joseph
Published: July 2023

Let's escape our caves and, quite literally, spend more time philosophizing in the great outdoors.
Post-Transplantations-Diabetes mellitus
Authors: Ott Undine
Published: July 2023

Die Zahl der Transplantationen ist rückläufig. Umso wichtiger ist eine konsequente Nachsorge zur Erhaltung der Transplantatfunktion. Eine häufige Komplikation (10–40 %) ist der Post-Transplantations-Diabetes mellitus (PTDM). Besonders im ersten Jahr ist das Erkrankungsrisiko hoch. Alter, Übergewicht, männliches Geschlecht, eine präexistente Insulinresistenz sowie die immunsuppressive Therapie begünstigen das Auftreten. Der PTDM führt zu hoher kardiovaskulärer Mortalität. Der orale Glukosetoleranztest (oGTT) stellt den Goldstandard der Diagnostik dar. Zusätzlich werden Nüchtern- und Spontanglukose sowie HbA1c herangezogen. Ein postoperativ diagnostizierter PTDM sollte mit Insulin behandelt werden. Eine frühe Intervention verzögert die Entwicklung einer relevanten Glukosestoffwechselstörung häufig über viele Monate. Die therapeutischen Möglichkeiten sind vielfältig und beinhalten neben der Blutzuckereinstellung die Behandlung kardiovaskulärer Risikofaktoren (Hyperlipidämie, Hypertonie). Patientenschulungen sind sinnvoll.
Plato and the Metaphysical Feminine
Authors: Han Irene
Published: July 2023

This book offers a new interpretation of the role of the female and the feminine in Plato’s political dialogues—The Republic, Laws, and Timaeus—informed by Deleuze’s film theory and Irigaray’s psychoanalytic feminism. The book reads Plato against the grain and tries to close the gap between the vitalists and Plato, rather than magnifying their differences. It probes the ambivalence that the vitalist tradition, Irigaray, and Derrida have toward Platonism. The application of Deleuzian and Irigarayan concepts to the ancient texts produce a new reading of Plato: the book focuses on the centrality and importance of motion, change, sensuality, and becoming to Platonic philosophy and, thereby, reinterprets Platonic philosophy in the direction of Heraclitus rather than Parmenides, as feminist rather than masculinist, and as mimetic. That is, it prioritizes Heraclitean principles of movement and flux over Form, the feminine over masculine, and materiality, feeling, or sensation. The book illustrates how, in Plato’s thought, the feminine maps itself onto the plane of phenomena—a plane associated with vitalist themes such as motion, tactility, and change (metabolē). The book aims to recontextualize Platonic metaphysics by illustrating how Being expresses itself through processes of (feminine) becoming. With this reformulation, the author’s account of Platonic Being destabilizes any purported Platonic dualism.
Goodbye to Language
Authors: Han Irene
Published: July 2023

The chapter turns to the chōra in the Timaeus, a concept that has intrigued numerous modern theorists such as Levinas, Derrida, and Kristeva. As opposed to passive space, the chapter reconceptualizes chōra as dynamic space by recasting it in the vitalist framework. Through this lens, we might better understand why it is a “third type” (Pl. Ti. 52a), an intensive space that acts as the container for active and passive objects and provides the medium for change. As the nurse of the generated world (Pl. Ti. 51a-b), the maternal chōra is directly associated with the realm of becoming, while eluding the active/passive binary opposition, and generates new ontological realities and political backgrounds. The chapter zooms into the gendered language that Plato uses to describe the chōra and identify other choratic apparatuses that persist into the temporal, political period, including the wandering womb, cave, and polis. The author’s view is that the chōra serves as the principal cause of metabolē and deposes, by mixing and multiplying, the metaphysical hierarchy that Platonic dualism supports.
Conclusion
Authors: Han Irene
Published: July 2023

The chapter revisits the significance of the mirror as the quintessential tool of mimēsis and explains that it serves as the perfect symbol for what is achieved in the dialogues: they offer up images of transcendent force and the divine. It summarizes the author’s reading and approach: in the use of these conceptual apparatuses, this reading elevates the mirror, specularity, and visual appearances, as described by Irigaray in “Plato’s Hystera”: “Occasionally the son/sun gives a new silver-backing to the mother-mirror … Enumeration of mornings and evenings, sunrises and sunsets, seasons, years. Over and over again. Like and unlike. Harmoniously ordering the process of living beings, but under the constant threat of materialist anarchy. Teaching them to count—moving image of a time without memory—but also to measure and survey the earth” (Irigaray 1985, 302–303). Irigaray’s method of deconstruction resonates with the Deleuzian aim of overthrowing Platonism by inverting the hierarchy between essence and Appearance, Model and Copy, Same and the Like, and thereby invests what has been repressed—simulation, the phantasm, the copy of a copy—with positive power. Both Irigaray and Deleuze challenge binary oppositions and their hierarchal values. They strive to escape Platonic dualism by eradicating the subject/object distinction, introducing new frameworks, and expanding the philosophical vocabulary.
Alternative Communities
Authors: Murray Alex
Published: July 2023

This chapter examines Decadent-conservative little magazines, short-lived publications edited by ambitious young men who sought to fuse conservative principles with progressive art. These young reactionaries drew on eighteenth- and nineteenth-century Tory traditions as they opposed what they perceived to be the bourgeois, populist turn in Victorian politics. The Whirlwind (1890) articulated an aggressively Jacobite politics while featuring art and literature by a range of figures associated with Decadence, including Stéphane Mallarmé, Arthur Machen, and James McNeill Whistler. The Senate (1894–7), also published a range of Decadent writers, including W. B. Yeats, Arthur Symons, Paul Verlaine, and Vincent O’Sullivan, and defended Oscar Wilde after his arrest for gross indecency, while also becoming a platform for conservative individualism. These periodicals offer an alternative to the more well-known coteries of The Yellow Book and The Savoy, demonstrating the symbiotic relationship between radical art and reactionary politics at the fin de siècle.
Decadence, Imperialism, and Jingoism
Authors: Murray Alex
Published: July 2023

This chapter examines various responses to the Second Anglo-Boer War (1899–1902), arguing that the intersection of aestheticism and jingoism reveals the conservative, martial strain in Decadence. The chapter opens with poetic responses to the war from Algernon Charles Swinburne, Lionel Johnson, John Davidson, and Michael Field. Their attempts to memorialize the fallen soldiers of the British Empire of this conflict reveal a sentimental nationalism which is striking and uncomfortable, given the cosmopolitan frameworks we have for reading Decadent literature. The chapter goes on to consider The Anglo-Saxon Review (1899–1901), a sumptuous magazine edited by Lady Randolph Churchill, with assistance from her son Winston. As I argue, in the design—both physical and conceptual—the Churchills attempted to fuse aesthetic elitism with imperialism.
A Life Course Approach to Lung Function Impairment and COPD
Authors: Bui Dinh S. , Dharmage Shyamali C.
Published: July 2023

Chronic obstructive pulmonary disease (COPD), an adverse outcome of chronic lung function impairment, was traditionally considered a disease of adult male smokers that resulted only from accelerated lung function decline. That dogma has now been overturned with recent evidence showing smoking is not the only risk factor, and lower lung function trajectories starting from early life can lead to COPD. More specifically, recent studies have provided evidence of three distinct adverse lifetime lung function trajectories that lead to COPD. In parallel, there is increasing recognition in the field of COPD that the disease imposes a significant burden on females and that females may even be more susceptible to certain risk factors that play a role in COPD aetiology. In addition, female reproductive factors that act throughout the lifespan are now emerging as novel risk factors for lung function deficits and COPD. Overall, a life course approach to reduce lung function impairment will enhance lung health of the community in future decades, and more investigations into potentially modifiable female reproductive adverse exposures are recommended to develop female-specific interventions to promote lung health. This chapter summarises the development and ageing of lungs, the development of COPD, and risk factors throughout the life course, while highlighting the issues specific to females in these areas.
Gynaecological Cancers
Authors: Jordan Susan J. , Webb Penelope M.
Published: July 2023

Globally, almost one fifth of cancers in women arise in the gynaecological tract, but rates of the individual cancer types vary widely between high- and low-income countries, reflecting the different prevalence of risk factors and access to screening. In this chapter, we review the factors that affect cancer risk across the life course, focusing on the three most common gynaecological cancers: endometrial, ovarian, and cervical cancer. We have separated the chapter into reproductive life stages—early life to menarche, menarche to menopause, and postmenopause. We end with a discussion of opportunities for prevention and how a life course approach could increase our understanding of how these cancers develop.
Structural Sexism Across the Life Course
Authors: Kelley Jessica A. , Gilbert Marissa
Published: July 2023

Structural sexism refers to beliefs, policies, and practices at any level of society or organisation that is derived on the basis of sex and gender, leading to inequity. The impact of this social inequality on women’s health begins as early as preconception and early childhood and accumulates with each life stage. Therefore, it is pertinent to consider how structural sexism shapes women’s health throughout the life course. We highlight how women are financially, physically, and mentally disadvantaged by the expectations of caregiving, the event of de-partnering or widowhood, as well as the higher prevalence of stressors and trauma that they experience. These have long-lasting negative effects on health for middle-aged and older women. We make a point that research has primarily focused on the typical life course of privileged individuals and contend that structural sexism differs for women in other subpopulations, which need to be addressed in future studies. Incorporating the perspective of structural sexism with the biological aspects of women’s health will lead to a better understanding of health disparities across the life course.
The Influence of Gender-Based Violence Across the Life Course
Authors: McLindon Elizabeth , Kyei-Onanjiri Minerva , Hegarty Kelsey
Published: July 2023

Violence against women (VAW) is a prevalent global health and social issue affecting women and children of every age and stage. From pregnancy through to our final years, violence and abuse can profoundly alter the health, relationships, and opportunities of those it is directed towards. Starting with the definition of violence across the life course, this chapter presents the global prevalence of physical, sexual, and psychological violence against children, adolescents, adults, and older people and the complex contributing factors. Adopting an ecological lens, the life course literature is synthesised to examine the longitudinal impacts of VAW, using the example of the most prevalent form—intimate partner violence. The key questions that this chapter seeks to answer are: Does exposure to violence during childhood alter the violence-exposure trajectory during adulthood? What are the health and social impacts of VAW? What are the risk and protective factors for VAW across the life course? Is VAW preventable? The ‘Shadow Pandemic’ is explored, presenting the case that COVID-19 may increase the risk factors for VAW as well as compound harmful impacts. Finally, the evidence of posttraumatic growth to emerge out of the suffering of people with lived experience of VAW indicates hope towards recovery.
A Life Course Approach to Women’s Health
Authors: Hardy Rebecca , Kuh Diana , Mishra Gita D.
Published: July 2023

As in the first edition of this book, the evidence reviewed suggests that adverse physical and psychosocial environments in early life affect biological and psychological development with long-term health consequences for women. Since the first edition, there has been a substantial increase in the evidence supporting the impact of reproductive characteristics across life (from menarche to menopause) on women’s health throughout the life course. Social inequalities in health among women are persistent, and a life course approach remains needed to further understand what underlies the development of such inequalities. A better understanding of the underlying mechanisms and causal pathways across life is starting to accumulate, with new developments in genetics, data, and methodology. The global COVID-19 pandemic, starting in 2020, has obviously had a major impact on health, and the longer term consequences have begun to be studied. A major challenge, therefore, for life course epidemiology going forward, is to integrate both the study of communicable and noncommunicable diseases, in terms of risk factors and consequences, with the study of the impact of pandemic control measures on multiple generations of women and girls. Finally, it is pleasing to observe an increase in acknowledgement of the need for a life course approach to women’s health policy and health care.
Introduction
Authors: Quevedo Marysol
Published: July 2023

This chapter introduces readers to the book’s main objective: tracing the classical music networks that Cuban composers cultivated between 1940 and 1991 through examining compositions, ensembles, and cultural institutions with a microhistorical approach. It sets the foundation for investigating how aesthetics and politics intersected in the case studies explored throughout the book: individual points of view largely determined the degree to which composers engaged in various local and international artistic networks; and these networks were constantly being nurtured and shaped by their actors, who also had to contend with national and global political and economic circumstances. This chapter provides readers with working definitions of key concepts: modernism, avant-garde, experimentalism, and vanguardia. Key figures Fernando Ortiz and Alejo Carpentier and their contributions to the intellectual milieu that Cuban composers inhabited—especially the concepts of transculturation and lo real maravilloso, respectively—are also discussed. It contextualizes the book within existing scholarship on twentieth-century classical music of the Americas, Eastern Europe, and the Cold War, as well as those dealing with Cuban music and Cuban studies more broadly. The chapter also provides an overview of the author’s methodology and sources, as well as summaries of the book’s chapters.
Epilogue
Authors: Quevedo Marysol
Published: July 2023

This Epilogue summarizes salient political and cultural events in Cuba since 1991 and their effects on the classical music scene. It begins with the impact of the período especial on a younger generation of Cuban composers, many of whom left Cuba to pursue professional careers elsewhere. It discusses how new technologies and changing relations between the US and Cuban governments have allowed for greater ease of cultural exchanges than in the three preceding decades. The chapter takes into account how the Cuban State’s policies affect the music industry: from a proliferation of independent music studios and labels after the legalization of small private businesses to the repressive measures of Decreto 349 and the subsequent backlash. This section closes with a reflection on Benitez Rojo’s The Repeating Island as a framework for understanding the cyclical patterns in Cuban music history and the challenging of Western teleological historical narratives that have overlooked many of the composers and works explored in this book.
Investor Demand for Leverage: Evidence from Equity Closed-End Funds
Authors: Dam Robert , Davies Shaun William , Moon S Katie
Published: July 2023

We provide evidence that investors with leverage constraints demand leverage for the sake of leverage. We study the equity closed-end fund (CEF) market and document a strong positive relation between fund leverage and CEF premiums, indicating that investors pay a relative premium for leverage. We perform a quasi-natural experiment and identify leverage as a causal driver of the premium. Leverage changes do not signal improved fund performance. Instead, the only benefit to investors of increased leverage is amplified exposure via greater volatility and risk exposure. We supply external validity by relating our results to the betting-against-beta factor. (JEL G12, G14, G32)
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids
Authors: Li Dmitriy , Elankumaran Paarthiphan , Kudinha Timothy , Kidsley Amanda K. , Trott Darren J. , Jarocki Veronica Maria , Djordjevic Steven Philip
Published: July 2023

Extraintestinal pathogenic

Escherichia coli

(ExPEC) are the most frequent cause of urinary tract infections (UTIs) globally. Most studies of clinical

E. coli

isolates are selected based on their antimicrobial resistance (AMR) phenotypes; however, this selection bias may not provide an accurate portrayal of which sequence types (STs) cause the most disease. Here, whole genome sequencing (WGS) was performed on 320

E. coli

isolates from urine samples sourced from a regional hospital in Australia in 2006. Most isolates (91%) were sourced from patients with UTIs and were not selected based on any AMR phenotypes. No significant differences were observed in AMR and virulence genes profiles across age sex, and uro-clinical syndromes. While 88 STs were identified, ST73, ST95, ST127 and ST131 dominated. F virulence plasmids carrying senB-cjrABC (126/231; 55%) virulence genes were a feature of this collection. These senB-cjrABC+ plasmids were split into two categories: pUTI89-like (F29:A-:B10 and/or >95 % identity to pUTI89) (n=73) and non-pUTI89-like (n=53). Compared to all other plasmid replicons, isolates with pUTI89-like plasmids carried fewer antibiotic resistance genes (ARGs), whilst isolates with senB-cjrABC+/non-pUTI89 plasmids had a significantly higher load of ARGs and class 1 integrons. F plasmids were not detected in 89 genomes, predominantly ST73. Our phylogenomic analyses identified closely related isolates from the same patient associated with different pathologies and evidence of strain-sharing events involving isolates sourced from companion and wild animals.
Histopathologic abundance of pigmentation correlates with disease‐specific survival in malignant melanoma but is not independent of current AJCC pT stage
Authors: Aebischer Valentin , Abu‐Ghazaleh Amar , Metzler Gisela , Riedl Lena , Garbe Claus , Flatz Lukas , Eigentler Thomas , Forchhammer Stephan
Published: July 2023

The increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow‐up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)‐stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma‐specific survival was calculated. Unpigmented melanomas (n = 99) had a melanoma‐specific survival of 67.7%, melanomas with moderate pigmentation (n = 384) had a melanoma‐specific survival of 85.9%, and strongly pigmented melanomas (n = 292) had a melanoma‐specific survival of 91.4% (p < .001). In an analysis of melanoma‐specific survival adjusted for pT stage and pigmentation, we found a nonsignificant impact of pigmentation abundance with a hazard ratio of 1.277 (p = .74). The study presented here provides evidence in a German cohort that patients with pigmented melanomas have a more favorable prognosis than those diagnosed with nonpigmented melanomas. Moreover, the abundance of pigmentation already seems to provide a first prognostic estimate. However, it does not appear to provide significant additional value for prognostic assessment according to the AJCC 2017 pT classification.
Microstructure Analysis and Finite Element Modelling for Creep Failure Prediction and Fitness-For-Service Assessment of Superheater Tubes
Authors: Zangeneh Sh. , Lashgari H. R. , Moazed Reza
Published: July 2023

This study aimed to perform a fitness-for-service assessment and investigate the root cause of failure of Grade 14CrMo3 steel seamless tubes typically used in superheaters in power generation plants. For this purpose, samples were taken from in-service superheater tubes in a 320 MW power plant. Thickness and hardness measurements were taken from the samples, and microstructural analyses were performed using scanning electron microscopy equipped with energy dispersive X-ray spectroscopy and X-ray diffraction. The results showed the presence of vanadium (V) and sulfur (S) elements on the tubes' external surface (flue gas facing-side), which is indicative of fuel ash corrosion. The formation of low melting point salts, such as Na2SO4, NaVO3, Na2O, and V2O5 (particularly between 10 and 2 o'clock positions) and degradation of the protective oxide layer led to loss of tube wall thickness. On the steam side of the tubes, the formation of an iron oxide layer (particularly between 12 and 2 o'clock positions) and the presence of water in the steam due to the improper function of the steam drum created an insulated zone leading to the formation of localized hot spots, creep microvoids, and spheroidization of carbides. In addition, a thickness reduction of 18% resulted in a considerable increase in hoop stresses having a detrimental effect on the remaining creep life. To explain the creep damage mechanism and determine the remaining creep life, the Larson–Miller criteria and API 579-1/ASME fitness-for-service-1 guidelines were utilized. The effects of the reduction in wall thickness were considered by performing a three-dimensional finite element analysis. The results showed that a temperature increase of only 50 °C (from 480 °C) could decrease the life of the tubes from 30 years to less than a year.
Social Equity and Urban Housing Policy Failures: Evaluation for Rehabilitation and Housing Resettlement Plans and Policies in Indian Cities
Authors: G Jayanandini
Published: July 2023

Today’s Indian cities are confronted with a wide range of problems due to social equity and urban housing policy failures, including rising populations, shifting family structures, increasing numbers of people living in informal communities and slums, inadequate urban infrastructure, growing environmental concerns, and an increase in migration. India has a severe housing shortage. A significant chasm separates housing demand from the supply. The discrepancy has led to the proliferation of urban slums, where millions of people are subjected to the lowest sanitation and hygiene standards. Housing policies in Indian cities include increasing taxes on unused or uninhabited land to fund the construction of low-cost dwellings, altering zoning laws to mandate that builders, and promoting higher densities of houses to spread out infrastructure costs among a larger population. Many people who have been the beneficiaries of land acquisition or other forms of forcible relocation are eligible for assistance through the Rehabilitation and Housing Resettlement Program. The proposed method included the city’s slums in the Advanced Smart Urban Missions (ASUM) planning process to overcome housing policy failures. A three-dimensional social equity framework with dispersion, identification, and protocol dimension aspects is applied to evaluate formal recovery plans’ objectives, priorities, and tactics. One of the most critical aspects of providing more housing alternatives for more people is ensuring everyone can afford it. Human rights, different perspectives, development initiatives in India, and policy inclusivity were also investigated. It makes suggestions for improving intelligent city policy that considers the needs of the city’s disadvantaged populations. This study looks into the problems that slum dwellers have with relocation and evictions and is limited to establishing various Smart Urban Missions. The research will help streamline the intelligent city development process sequentially, improving conditions for the urban poor and disadvantaged.
ROLE OF THE WOMAC SCORES IN PREOPERATIVE DECISION-MAKING AND ANALYSIS OF KNEE REPLACEMENT FOR KNEE OSTEOARTHRITIS PATIENTS
Authors: WANG WENBO , KUANG SHENGYU
Published: July 2023

Objective: Knee replacement (KR) is a widely accepted procedure for end-stage knee arthritis. Patients’ subjective perception of knee joint symptoms is an important factor in their decision to undergo knee replacement. This paper mainly studies the correlation between knee joint symptoms and knee replacement, aimed to establish the corresponding preoperative decision-making model. Methods: 122 knee arthritis patients were included from the knee arthritis database FNIH OAI, of which 61 had knee arthroplasty and 61 without knee arthroplasty. First, WOMAC score was used to quantitatively evaluate the knee joint symptoms of patients; then the correlation between clinical risk factors, single WOMAC score and knee replacement was analyzed. Then K-means cluster analysis was used to divide the multidimensional WOMAC score into different groups of knee arthritis symptoms’ severity. Finally, based on the retained clinical risk factors and WOMAC cluster variables, the clinical models, WOMAC scoring model and clinical +WOMAC scoring model were constructed, respectively, and compared. Results: Age and BMI were significant risk factors for knee replacement ([Formula: see text]), which could be used to construct the clinical model. There was no significant correlation between any single WOMAC score and knee replacement ([Formula: see text]). The cluster variable of WOMAC score obtained by cluster analysis was significantly correlated with knee replacement ([Formula: see text]). Based on the above risk factors, we established the Age+BMI, Cluster and Age+BMI+Cluster models, respectively. The comparison results showed that the Age+BMI+Cluster model ([Formula: see text]) showed the highest predictive value for knee replacement, and the corresponding nomogram also showed good predictive consistency; the performance of Cluster model ([Formula: see text]) was the second. The pure clinical risk factor model Age+BMI showed the worst predictive performance ([Formula: see text]). Conclusion: This paper analyzed the correlation between patients’ subjective perception of knee arthritis symptoms and the final knee replacement, and constructed a new biomarker based on the WOMAC score. After analysis and modeling, this marker could be used to predict knee replacement. The constructed Age+BMI+Cluster nomogram could be used for personalized assessment of the risk of knee replacement.
THE FINANCIAL EFFECTS OF THE FISCAL SOVEREIGNTY OF MUNICIPALITY REGARDING REAL ESTATE TAX
Authors: Agnieszka Żołądkiewicz-Kuzioła
Published: July 2023

The aim of the article is to identify the differentiation of the financial effects of a municipality’s fiscal sovereignty in the field of real estate tax from the point of view of such criteria as the type of municipality (rural, urban, urban-rural and town with poviat rights) and the type of fiscal sovereignty instrument (tax rates lower than the maximum, reliefs and exemptions, redemption of tax arrears, payment in instalments, deferral of the payment date). The research covering the years 2017–2021 was based on data from the Ministry of Finance. Based on the research, it was shown that the effects of fiscal sovereignty were the most significant in rural municipalities, while the smallest in towns with poviat rights. All types of municipalities used common instruments, such as e.g., the lowering of tax rates, to a greater extent than the discretionary instruments resulting from the Tax Ordinance.
Polarización territorial de la brecha de género del desempleo en Andalucía: un análisis exploratorio de datos espacio-temporales abiertos
Authors: Acevedo-Blanco Antonio-Jesús , Martínez-Quintana María Violante , González-Rabanal Miryam C.
Published: July 2023

Este artículo examina la distribución geográfica de la brecha de género en el desempleo en Andalucía y si presenta polarizaciones territoriales. Aplica el enfoque metodológico del análisis de datos espacial exploratorio y prueba las dependencias espaciales, local y global, utilizando para ello datos abiertos georreferenciados producidos por organismos oficiales para el período 2011-2022. A través de esta evaluación, se busca determinar si la brecha de género del paro en Andalucía sigue una distribución geográfica homogénea, o si, por el contrario, ofrece polarizaciones territoriales estables en el tiempo. Los resultados se presentan en mapas LISA (Local Indicators Spatial Association) formados por la estadística Diferencial I local de Moran en cada uno de los años de la serie. A partir de los resultados del colocation map de los clústeres LISA, se concluye que en Andalucía la brecha de género en el desempleo presenta un fuerte componente estructural, feminizado y geográficamente localizado.
Etats unitaires et enjeux territoriaux en Espagne et au Maroc
Authors: Naciri Mohammed
Published: July 2023

Materiales y anexos
Isolation of pectic acids from bleached TMP water and aggregation of model and TMP pectic acids by calcium
Authors: Saarimaa Ville J. , Pranovich Andrey V. , Sundberg Anna C. , Holmbom Bjarne R.
Published: July 2023

Pectins are important structural elements in spruce fibres. Alkaline peroxide bleaching of spruce thermomechanical pulp (TMP) causes degradation and demethylation of pectins, yielding high-charge-density pectic acids. The pectic acids in fibres contribute strongly to the negative fibre charge, and the dissolved pectic acids increase the cationic demand of bleached TMP water. In this study, a method to isolate pectic acids from peroxide-bleached TMP pulp water is presented. The pectic acids were isolated and purified in good yield using a polyacrylate resin to remove lignin, a cellulose filter to remove galactoglucomannans (GGM), and an anion exchange resin to separate pectic acids from neutral carbohydrates. Salts and residual low-molar-mass carbohydrates were further removed from the isolated pectic acids by dialysis. The isolated pectic acids (>80% purity) had a low molar mass and a wide polydispersity (5.9 kDa, MW/MN 3.3). The aggregation and precipitation of the isolated pectic acids, as well as citrus fruit pectic acids with well-defined molar masses, by Ca2+-ions were studied. The molar mass of pectic acids was a key factor determining the precipitation of Ca2+-pectates. Pectic acids below 6 kDa were not precipitated by Ca2+, while higher molar masses led first to partial and then to complete precipitation. The precipitated Ca2+-pectates may impair paper machine runnability and paper quality.
Bursa Orman Bölge Müdürlüğü Saçlı meşe (Quercus cerris) meşcerelerindeki büyüme ilişkileri
Authors: SÖNMEZ Turan , GENCAL Burhan
Published: July 2023

Türkiye’de geniş bir yayılışa sahip meşeler ormanların sürdürülebilir yönetimi ve korunması için tür bazında artım ve büyüme ile hasılatına dair bilgilere ihtiyaç vardır. Bu bilgiler, sadece yakacak ve yapacak odunun hasılatını belirlememizin yanında, hayvan besini olarak kullanılan meyve, yapraklar, uçucu bileşikler içeren kabuklar ve meyve kabukları gibi değerli yan ürünlerin elde edilmesine de katkı sağlamaktadır. Bu çalışma, Türkiye’deki 17 meşe türünün tür bazında incelenmesi gerekliliğini vurgulamaktadır. Bursa Orman Bölge Müdürlüğü’nde (OBM), Saçlı meşe (Quercus cerris L.) meşcerelerinde yapılan bu araştırmada, tek ağaç ve meşcere parametreleri arasındaki ilişkiler ele alınmıştır. Tek ağaç ilişkileri göğüs çapı ile dip çap ilişkisinin (d1.30 - d0.30) en yüksek belirtme katsayısına sahip olduğunu (R2: 0.972) göstermiştir. Bunu sırasıyla çift kabuk kalınlığı ile göğüs çapı, ağaç boyu ile göğüs çapı ve son olarak ağaç yaşı ile göğüs çapı ilişkileri izlemiştir. Meşcere bazlı ilişkilerde ise, meşcere yaşının meşcere içinde bulunan ağaç sayısı (T-N) ile ilişkisi en yüksek belirtme katsayısına (R2: 0.776) sahiptir. Bunu sırasıyla meşcere ağaç sayısı ile göğüs yüzeyi orta ağacının çapı, meşcere yaşı ile meşcere orta boyu ve meşcere üst boyu ile meşcere yaşı ilişkileri izlemiştir.
EFEITOS DA ASSISTÊNCIA FISIOTERAPÊUTICA DURANTE O PERÍODO GESTACIONAL: UMA REVISÃO INTEGRATIVA COM ÊNFASE NO TRATAMENTO DA DOR
Authors: Egito Rafaela Andriola Nóbrega do , Sales Weslley Barbosa , Oliveira Allanna Stephany Cordeiro de , Pereira Luís Eduardo Alves , Dias Vanessa da Nóbrega
Published: July 2023

A fisioterapia possui grande eficácia da redução das dores e da qualidade de vida da mulher durante o período gestacional, tendo em vista isso, os autores realizaram uma pesquisa com objetivo de avaliar os efeitos da abordagem fisioterapêutica no pré-parto e propor um protocolo de intervenção baseado na escala visual analógica (EVA) de dor. Assim, objetivou compreender os principais meios utilizados pela Fisioterapia para o tratamento da dor no trabalho de parto. Esse estudo é caracterizado como uma revisão integrativa de literatura, de abordagem descritiva e de caráter qualitativo, que se dá por meio do levantamento de artigos científicos que estivessem relação com o objetivo do estudo. Para elaboração do título e pergunta norteadora, seguiu-se a estratégia PICO (Population, Intervention, Comparison, Outcome) e as diretrizes metodológicas de acordo com PRISMA. Mediante o exposto, observa-se que a atuação da fisioterapia é de suma importância dentro do contexto obstétrico, proporcionando uma maior qualidade de vida, funcionalidade, redução do quadro álgico durante e após o parto, bem como reduz significativamente o tempo de parto, prevenindo complicações e agravos a saúde materno-infantil. O suporte fisioterapêutico inclui banhos, crioterapia, massagens, técnicas respiratórias, deambulação, posições verticais e a neuroeletroestimulação transcutânea (TENS). Evidenciando que o fisioterapeuta se mostrou útil no acompanhamento da mulher durante o processo parturitivo, ajudando na redução da percepção dolorosa e na diminuição do tempo de trabalho de parto.