bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of the mechanisms of anti-inflammatory action of cryopreserved placenta extract and diclofenac sodium by their threaded administration
Authors: Hladkykh F. V. , Chyzh M. O.
Published: February 2022

Introduction. Inflammation is a complex multicomponent adaptive pathological process based on three enzymatic pathways of arachidonic acid metabolism: cyclooxygenase, lipoxygenase and epoxygenase. Nonsteroidal anti-inflammatory drugs are the most numerous and most widely used group of drugs used in the pharmacocorrection of inflammatory processes of various etiologies.
Purpose of the study. The aim is to characterize the effect of cryopreserved placenta extract on the anti-inflammatory activity of diclofenac sodium with their threaded administration in a model of zymosan-induced inflammation.
Materials and methods. In vivo experimental studies were performed on 28 nonlinear laboratory male rats weighing 200–220 g. Acute exudative inflammation was reproduced by subplantar administration of rat limb 0,1 ml of 2,0% zymosan suspension. The anti-exudative effect was assessed by the magnitude of limb edema, which was assessed using an aqueous plethysmometer.
Results and discussion. The study showed that subplantar administration of 2,0% suspension of zymosan led to a statistically significant (p < 0,05) increase in the volume of the damaged limb after 30 minutes. by 28,1 ± 5,4% relative to baseline and was 2,01 ± 0,06 ml. The most pronounced and almost comparable anti-inflammatory activity was observed against the background of the use of cryopreserved placenta extract and the combined use of diclofenac sodium and cryopreserved placenta extract. Thus, for 60 min the antiinflammatory activity was (p < 0,05) 46,5% and 53,2%, respectively.
Conclusions. It is established that one of the leading mechanisms of anti-inflammatory activity of cryopreserved placenta extract is the inhibition of the lipoxygenase pathway of arachidonic acid metabolism. This was indicated by statistically significant (p < 0,05) suppression of zymosaninduced inflammation in rats by 78,8% and 74,8% by 120 and 180 min, respectively.
Unilateral spinal anesthesia and the sciatic nerve block in foot surgery
Authors: Gritsenko S. N. , Shapoval S. D. , Filimonov R. V.
Published: February 2022

Purpose of the study. To evaluate the effectiveness of unilateral spinal anesthesia as a method of pain relief during foot surgery. Analyze the effectiveness of unilateral spinal anesthesia versus sciatic nerve block. To develop an algorithm for performing unilateral spinal anesthesia during foot surgery.

Materials and methods. We examined 64 patients who were treated in the department of purulent surgery of the 3rd city hospital in Zaporozhye with a diagnosis of diabetic foot syndrome in the period from 2017 to 2019.

Research methods. Assessment of the level of pain intensity using the standard visual analogue scale and the concentration of glucose in the blood serum. Monitoring of the parameters of the cardiovascular system, the temperature of the skin of the lower leg during anesthesia, Doppler scanning of the peripheral circulation in the foot.

Results. 4 hours after performing anesthesia, the intensity of pain during movement of the lower limb, according to the visual analogue scale in the group with unilateral spinal anesthesia was 2,3 times less than in the group with sciatic nerve block (p < 0,05). After 10 hours – in the sciatic nerve block group there was a 9,4% increase in comparison with the unilateral spinal anesthesia group (p < 0,05). Compared with the unilateral spinal anesthesia group, in the sciatic nerve block group 20 minutes after anesthesia, the heart rate decreased by 7,2% (p < 0,05). After unilateral spinal anesthesia, the level of systolic blood pressure on 1 toe of the foot increased by 18,3% 20 minutes after anesthesia, and 20 minutes after sciatic nerve block – by 13,7% (p < 0,05). In patients with the unilateral spinal anesthesia group, the temperature on the operated lower limb after anesthesia increased by 3,8%, in the sciatic nerve block group – by 2,8% (p < 0,05).

Conclusions. Regional anesthesia is the main method of choice for foot surgery compared to general anesthesia. sciatic nerve block does not in all cases lead to 100% surgical anesthesia and requires additional medical analgosedation. For foot surgery, unilateral spinal anesthesia is preferred.
The absorptive and metabolic features of phagocytosis in children, depending on the frequency of acute respiratory infections
Authors: Ovcharenko L. S. , Tymoshyna O. V. , Vertehel A. O. , Andrienko T. G. , Samokhin I. V. , Kryazhev O. V. , Chakmazova O. M.
Published: February 2022

Purpose of the study. To improve of innate immune disorders diagnosis in preschool children with respiratory tract recurrent infectious diseases on the basis of new data of phagocytosis parameters by studying its absorption and prooxidant characteristics.

Materials and methods. Under observation were 60 children aged 2 to 5 years. Two groups were formed: 1). children with respiratory tract acute infectious more than 6 times in year (n = 30); 2). children with respiratory tract acute infectious 6 or less times in year (n = 30).

Results. Among children in 1 group, statistically significantly increased the registration quantity of low phagocytic counts (by 60,0%, p < 0,05), phagocytic index (by 56,0%, p < 0,05), index of phagocytosis completeness (70,0%, p < 0,05), neutrophil phagocytic activity stimulated by staphylococcus (50,0%, p < 0,05) and high rates of spontaneous neutrophil phagocytic activity (43,3%, p < 0,05), high serum levels of lipid hydroperoxides (by 80,0%, p < 0,05), diene conjugates (by 80,0%, p < 0,05), malonic dialdehyde (76,7%, p < 0.05), diene ketones (76,7%, p < 0,05), Schiff bases (76,7%, p < 0,05).

Conclusion. In children 2–5 years with respiratory tract acute infectious more than 6 times in year the phagocytic dysfunction and increased lipid peroxidation were established. It is characterizing the failure and slowness of the early immune response.
Variability of arterial hypertension as an additional factor to cardiovascular risk in atrial fibrillation
Authors: Dotsenko N. Ya. , Herasymenko L. V. , Shekhunova I. A. , Boev S. S. , Molodan А. V. , Malinovskaya A. Ya. , Yatsenko O. V.
Published: February 2022

The article presents a review of the literature on the role of hypertension in the mechanisms of atrial fibrillation, therelationshipbetweenwhichincreases the risk of cardiovascular disease and mortality. The importance of taking into account the increased variability of BP in the development of target organ damage and adverse cardiovascular events is shown. Approaches to the choice of antihypertensive therapy in patients with hypertension and atrial fibrillation have been identified. It has been found that reducing BP variability can be added as one of the most important strategies in the treatment of hypertension and atrial fibrillation.
Inclusion of Cell Technologies in the Protocol of Immunosuppression in Liver Transplantation
Authors: Коротков С.В. , Носик А.В. , Примакова Е.А. , Петровская Е.Г. , Назарова Е.А. , Дедюля Н.И. , Ефимов Д.Ю. , Пикиреня И.И. , Щерба А.Е. , Кривенко С.И. , Руммо О.О.
Published: February 2022

Современная иммуносупрессивная терапия обеспечивает хорошую долгосрочную выживаемость трансплантатов печени и пациентов после операции. Тем не менее, прием иммуносупрессантов сопряжен с развитием побочных эффектов - почечного повреждения, метаболического синдрома, инфекционных осложнений и повышения риска развития онкологических заболеваний. Альтернативой стандартной иммуносупрессивной терапии являются клеточные биотехнологии, позволяющие замещать иммуносупрессивный эффект протокольной иммуносупрессии без риска развития отторжения. В данной публикации продемонстрированы основные результаты экспериментальных и клинических исследований по изучению применения мезенхимальных стволовых клеток в трансплантации солидных органов. Применение мезенхимальных стволовых клеток жировой ткани на базе Минского научно-практического центра хирургии, трансплантологии и гематологии у пациентов после трансплантации печени сострым почечным повреждением позволило редуцировать дозу базового иммуносупрессанта такролимуса без риска развития отторжения и способствовало быстрому восстановлению почечной функции. На основании проведенного анализа сделаны выводы о целесообразности разработки методов лечения пациентов после органных трансплантаций.

Modern immunosuppressive therapy provides good long-term survival of liver transplants and patients after surgery. Nevertheless, immunosuppression is associated with development of adverse effects - kidney injury, metabolic syndrome, infectious complications, and increase of the risk of cancer. Cell biotechnologies are an alternative to the standard immunosuppressive therapy, which lets to replace the immunosuppressive effect of protocol immunosuppression without the risk of rejection. This publication demonstrates the main results of experimental and clinical studies of application of mesenchymal stem cells in solid organ transplantation. Application of mesenchymal stem cells of adipose tissue at the Minsk Scientific-Practical Center for Surgery, Transplantology and Hematology in patients after liver transplantation with acute kidney injury allowed to reduce the dose of the basic immunosuppressant tacrolimus without the risk of rejection and promoted rapid renal function recovery. On the base of analysis, the conclusions were made about the advisability of development of the methods for treatment of patients after organ transplantation with MSCs.
Prenatal Diagnosis of Apert Syndrome
Authors: Лазаревич А.А. , Венчикова Н.А. , Мараховская Э.И.
Published: February 2022

Цель исследования. Описать ультразвуковые и патоморфологические признаки синдрома Апера у плода. Материалы и методы. Сонография проводилась на аппарате Voluson 730 Expert с использованием трансабдоминального (4-8 МГц) датчика. Нозологический диагноз установлен по результатам патоморфологического исследования. Результаты. Основными ультразвуковыми (УЗ) признаками синдрома Апера в 19 недель 3 дня явились расширение боковых желудочков головного мозга, деформация черепа и синдактилия II-V кистей. Выводы. Несмотря на узнаваемый симптомокомплекс синдрома Апера, представленные наблюдения подтверждают сложность УЗ-диагностики данной патологии во втором триместре беременности. При УЗ-визуализации синдактилии кистей у плода необходимо провести исследование головного мозга для поиска возможных дополнительных маркеров краниосиностоза в виде деформации черепа, расширения и (или) атипичной формы боковых желудочков, агенезии (дисгенезии) мозолистого тела.

Purpose. To explore the ultrasound and pathomorphological signs of Apert syndrome in the fetus. Materials and methods. Sonography was performed on a Voluson 730 Expert using a transabdominal (4-8 MHz) sensor. The nosological diagnosis is established by the result of pathomorphological and histological studies. Results. We present sporadic case of Apert syndrome in the fetus of the second trimester. The ultrasound (US) signs were expansion of the lateral ventricles of the brain, deformation of the skull and syndactyly of II-V hands. The diagnosis was established by pathomorphological expertise. Conclusions. Apert syndrome characterized by a unique set abnormalities, but it is difficult to determine prenatal diagnosis in second trimester. With ultrasound imaging of fetal hand syndactyly, it is necessary to study of the brain to search for possible additional markers of craniosynostosis: deformation of the skull, expansion and/or atypical shape of the lateral ventricles, agenesis (dysgenesis) of the corpus callosum.
Enzymatic Activity of the Oral Fluid in Patients with Chronic Recurrent Aphthous Stomatitis and Diseases of the Gastrointestinal Tract in the Dynamic of Treatment
Authors: Кулиева Л.Х.
Published: February 2022

Проблема комплексного подхода к лечению хронического рецидивирующего афтозного стоматита и выработки эффективной терапии остается актуальной и важной в стоматологии. Хронический рецидивирующий афтозный стоматит встречается наиболее часто среди всех заболеваний слизистой оболочки полости рта. Диагностика хронического рецидивирующего афтозного стоматита основывается на оценке клинических и лабораторных данных.

The problem of an integrated approach to the treatment of chronic recurrent aphthous stomatitis and the development of effective therapy remains relevant and important in dentistry. Chronic recurrent aphthous stomatitis occurs most often among all diseases of the oral mucosa. Diagnosis of chronic recurrent aphthous stomatitis is based on clinical and laboratory evaluation.
LISTERIA MONOCYTOGENES IN COW’S MILK PRODUCED BY FAMILY-OWNED DAIRY FARMS
Authors: Capriogli Oliveira Gabriela , Brancato Junqueira Nathália , De Freitas Guimarães Felipe , Salina Anelise , Morales Dalanezi Felipe , Bott Mantovan Karine , Fernandes Joaquim Sâmea , Menozzi Benedito , Langoni Helio
Published: February 2022

Refrigeration is an important milk preservation method. However, milk quality may deteriorate if the product is refrigerated for long periods, mainly due to the growth of psychrotrophic bacteria. This group of microorganisms includes pathogenic genera, most notably Listeria monocytogenes. The detection of this bacterium in food is important, given its pathogenic effects on human and animal health and also its economic relevance. This study focused on detecting the presence of L. monocytogenes in milk samples collected at small family-owned dairy farms. Samples were cultivated on PALCAM and ALOA agars for microbiological analysis and a molecular analysis by polymerase chain reaction was performed for the detection of L. monocytogenes.  Despite the negative results obtained in both these analyses, further studies are recommended to confirm or refute the negligible effect of L. monocytogenes on small dairy farms.
Pratique de la Social Network Analysis en égyptologie et apports à l'étude des réseaux de relations des élites en Égypte ancienne
Authors: Martinet Émilie
Published: February 2022

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Écriture, langue et images:
Authors: Vernus Pascal
Published: February 2022

Apparition et développement de la capacité symbolique. Distinction, parmi les codes graphiques produits par cette capacité, entre "sémiographies" et écriture au sens fort. Leurs manifestations et interrelations dans l'Égypte protodynastique. Les premières attestations d’écriture au regard des découvertes récentes ; son instrumentalisation au service du pouvoir : un soi-disant but «utilitaire» et un but «cérémonial».
Modelo pago por capitación ajustada por la diabetes mellitus tipo 2 en el sistema de salud colombiano
Authors:   , Caballero Otálora Adriana Marcela
Published: February 2022

Las enfermedades crónicas no trasmisibles [ECNT] han venido en aumento a nivel mundial debido principalmente a los hábitos de vida de la población tales como dieta alta en carbohidratos, sales y grasas no saturadas generando un impacto negativo en la población colombiana, este grupo de enfermedades paso del 46,2% en la carga enfermedad en 1990 a representar 69,2% en el 2017 (The institute for Health Metrics and Evaluation, 2020). Un subconjunto de las ECNT corresponde a enfermedades cardiovasculares las cuales representan el 17,1% seguida por las neoplasias con el 15,1%, a su vez la diabetes mellitus y la enfermedad renal crónica son el 6,4%.. Dado lo anterior los sistemas de salud a nivel mundial han venido desarrollando modelos de pago que permitan una distribución de recursos de manera eficiente, logrando con ello una mejor calidad de vida de los pacientes, por lo anterior el propósito del trabajo es presentar la estimación de la prima de unns seguro público y colectivo como es el caso colombiano, incorporando como ajustador de riesgo el tratamiento adecuado para mantener en control a un paciente diagnosticado con DM-II, para ello en la primera parte se abordan los diferentes mecanismos de pago que afectan la transferencia de los recursos dentro del Sistema General de Seguridad Social en Salud en Colombia, en la segunda parte se abordan algunos modelos de ajuste de riesgo, dando paso a los procesos metodológicos empleados en el análisis de inclusión de un factor de riesgo en la prima actual del sistema de salud colombiano, presentando un apartado de análisis de información y resultados, por ultimó se presentan las discusiones y conclusiones de la aplicación del modelo planteado
Factors influencing the effectiveness of antiplatelet therapy
Authors: Kantemirova Bela , Zhidovinov Aleksei , Abdullaev Musalitdin , Orlova Ekaterina , Chernysheva Elena , Sultanova Oksana
Published: February 2022

In recent years, significant advances in the diagnosis and treatment of cardiovascular diseases have been achieved in the healthcare of most countries. However, among the causes of mortality in patients with coronary heart disease, arterial thrombosis takes one of the leading positions. Antiplatelet drugs are prescribed to prevent thrombotic complications, which can be used as mono- or two-component therapy. In case of atherosclerosis in arteries, acetyl-salicylic acid (ASA) or clopidogrel can be used as monotherapy; treatment of acute coronary syndrome (ACS) and percutaneous coronary interventions (PCI) required using of double antiplatelet therapy (DAT), including acetylsalicylic acid drugs together with one antiplatelet agent from the group of thienopyridine derivatives — blockers of P2Y12 platelet receptors (clopidogrel, ticagrelor, prasugrel). In patients with ACS who underwent primary PCI or thrombolysis followed by PCI, the duration of DAT is 12 months, and clopidogrel is the drug of choice [16, 30]. According to various literature sources about 20–40% of patients have low effectiveness of antiplatelet therapy, which can lead to thrombosis, stent thrombosis and thromboembolic complications. This review provides an analysis of modifiable and nonmodifiable factors contribution to the development of clinical and laboratory resistance of antiplatelet agents.
Online Learning Contract: A Way Disciplining Students
Authors: Noviyanti Sari Dewi
Published: February 2022

The contract between teacher and student or what is often called as teacher-student agreement is one of the class management in applying student discipline. Good class management, especially in student discipline, is considered important in creating a conducive learning atmosphere. In conventional learning, teacher and student contracts regarding student discipline are related to how students' attitudes in participating in learning, such as students not being allowed to go around the class while learning is taking place, students are not allowed to be busy with other things besides those related to learning and others. At this time, when online learning or distance learning is applied, of course this contract is also undergoing changes. There is a disciplinary agreement between the teacher and students that adapts to distance learning conditions. This study aims to identify the learning discipline contract between students and teachers in distance learning. Questionnaires and interviews were used to collect data. The data were analysed descriptively to get a description of the agreement between teachers and students in online learning and the type of agreement that commonly used. The findings show that the most widely regulation is related to student’s obedience in following teacher’s instruction in online class. This study also revealed that learning contract is an effective way to create a successful online learning based on teacher’s perspectives.
Teachers’ Strategy to Develop Higher Order Thinking Skills in Reading Class
Authors: Fitriani Yesi Elsa , Syarifah Eva Fitriani , Emiliasari Raynesa Noor
Published: February 2022

This research aims to find out the strategies used by the teachers and the inhibiting factors that can influence the development of HOTS in Reading Class. It applied qualitative approach with case study research design. The subject of the research were two English teachers of Senior High School. The techniques of collecting the data were used observation and interview. The data were analyzed using the qualitative method there are data reduction, data display, and drawing conclusions. The finding of the research shows that there were 5 types of teaching strategies, including informing learning objectives, divergent questions, group discussion, giving feedback and giving motivation. The most dominant strategy used by the teacher was divergent question. Meanwhile, the learning objective and group discussion was the least prominent, with only 3 data. Then, five inhibiting process such as time, pupil learning ability, pupil’s mastery, planning domain, and class environment can influence the development of HOTS.
Pengaruh Motivasi Belajar dan Kompetensi Berbasis E-Learning di Masa Pendemi Covid-19
Authors: Chandra Yanita Ella Nilla , Syamsurizal Syamsurizal , Sakinah Rizka
Published: February 2022

This study aims to identify learning motivation and competency development based on e-development through e-learning for students to meet the needs of the work industry. This research uses a quantitative approach with explanatory research methods. The Department of Business Administration, State Polytechnic of Jakarta conducted this research. In this research, the population was 1,094 students of the Department of Business Administration, State Polytechnic of Jakarta. The sample used in this study was 100 taken by random sampling. The data collected in this study used a closed questionnaire with a Likert scale of 5. The data analysis carried out in this study was a multiple linear regression analysis. The research results explain that learning motivation influences the competence of lecturers and e-learning methods given to students. The research results also clarify that the competencies possessed in the online learning on the e-learning have a positive and significant effect through the e-learning method taught by lecturers.
Amministrative, regionali sarde e suppletive 2004: ancora sconfitte per il centro-destra
Authors: Di Virgilio Aldo
Published: February 2022

Le elezione comunali nei 30 capoluoghi. Il centro-sinistra riconquista Bologna.

Le elezioni provinciali. Il centro-destra perde Milano.

Le elezioni regionali sarde: il successo di Soru.

Le elezioni politiche suppletive: il centro-sinistra.
Reduction of copper oxide powder by an inductively coupled thermal plasma
Authors: Bissett H , Makhofane M , Lötter S
Published: February 2022

Additive manufacturing (AM) methods can be utilised to manufacture complex, custom Ti6Al4V components for medical implants. Infection at the bone-implant interface is a key reason for implant rejection. Advanced titanium implants with biocompatibility and antibacterial properties can be manufactured by modifying the titanium alloy with copper, which in small concentrations (< 1 at % copper) is a proven, non-toxic antibacterial agent. Copper can be embedded into the titanium implant during the AM process creating antibacterial functionality. In order to produce sufficiently fine metallic copper powder, copper oxide can be reduced, either by chemical reduction or thermal treatment methods. These include thermal decomposition or reduction of the oxide in the presence of a reactive gas at elevated temperatures. Making use of thermal treatment methods such as thermal plasma reduction, the process conditions can be tuned to manipulate the morphology and average particle size of the powders. The purpose of this study was to investigate the thermal plasma reduction of copper oxide to copper metal making use of the Tek-15 radio-frequency inductively coupled thermal plasma system at Necsa.

In the presence of hydrogen, the black copper (II) oxide powder was converted to a dark red powder, while a yellow / orange coloured powder was obtained without hydrogen being present. A change in composition was observed using SEM-EDS and was confirmed by XRD analysis.
Development of ATO as an alternative catalyst support for PEM fuel cells
Authors: Mkhabela M , Ngwenya T
Published: February 2022

Proton exchange membrane (PEM) fuel cells demonstrated to be feasible energy converters that convert chemical energy of fuels to electrical energy. The technology has proven to be competitive with conventional energy converters such as batteries and internal combustion engines. However; several challenges influence the commercialization of this technology which includes high costs, durability, and stability, which are contributed by the PEM fuel cell catalysts. Currently, the carbon-supported platinum electro-catalyst is being used. Unfortunately, carbon supports are not stable enough for fuel cell durability due to carbon corrosion on the cathode. Therefore it is necessary to replace carbon support materials to improve the durability of PEM fuel cells. In this study, antimony doped tin oxide (ATO) metal oxides are synthesized as alternative platinum catalyst support via co-precipitation with different antimony doping levels of 5, 7, and 10 %. The preliminary results of the acid resistance test show that the support is relatively acid-resistant with minor loss of dopant in acidic conditions. Surface area measurements, XRD, TEM, ICP characterization will be performed on the ATO before and after the addition of 40 wt. % of Pt particles. The mass and specific activity measurements for oxygen reduction reaction (ORR) and durability via ex-situ thin-fil rotating disc electrode (RDE) of Pt/ATO catalyst and the traditionally used Pt/C catalyst will be compared.
Univentricular Heart
Authors: Achraf Choukri Moulay , Salma Elyazidi , Youssef Ettaoumi
Published: February 2022

Introduction: The univentricular heart refers to a pathophysiological concept in which a single functional ventricle provides both pulmonary and systemic aortic flow in parallel. The aim of this study was to conduct an epidemiological study of the univentricular heart, to study the circumstances of discovery, to analyze the problems posed by the diagnostic and therapeutic management of these patients in our Moroccan context by evaluating the diagnostic role of Doppler echocardiography and finally evaluating the evolution of these operated children. Methods: This was a retrospective study in the cardiovascular surgery department of CHU IBN ROCHD in Casablanca, over a period of 3 years from January 2017 to December 2019 involving 4 patients, whose age varies between 6 months and 7 years. Results: The sex ratio was 1. The average age of the patients was 8 months and 6 years respectively for the pulmonary artery cerclage and for the Fontan treatment. Consanguinity, diabetes, hypertension and advanced maternal age were the main antecedents. Several circumstances of discovery have been highlighted, the most common are: perioral cyanosis in 3 patients, growth restriction with eating difficulties in 3 patients and dyspnea in 2 others. Pulmonary arterial hypertension and pulmonary stenosis were present in 50% of the patients. The diagnosis was made by echocardiography and the most common anatomical form of the single ventricle was tricuspid atresia in 2 patients. All patients were operated: 2 received pulmonary artery cerclage and 2 others received Fontan treatment, 1 of them had primary pulmonary artery cerclage in his history. In our study, no deaths were reported. Postoperative complications were dominated by atelectasis, infectious complications, bleeding and pleuro-pericardial effusion. The short and medium-term postoperative evolution was favorable for all our patients with weight gain, symptom reduction and improvement in O2 saturation.
Umbilical Hernia in Children at the Pediatric Surgery Unit of Fousseyni Daou Hospital in Kayes
Authors: M Kouyate , S Sangare , G Sogoba , B Dicko , A Diakite , M Magassa , M Kane , T Dembele
Published: February 2022

Introduction: A disease characterized by the protrusion of part of the intestine through the abdominal muscles at the level of the navel. Many infants are born with umbilical hernia especially in Africa. Materials and Methods: We conducted a retrospective study from January 2018 to December 2020. The objectives were to determine the hospital frequency of umbilical hernia at the regional hospital of Kayes, to describe the clinical and para-clinical aspects and finally to describe the immediate aftermath of surgical treatment. Results: During the period Janvier 2018 Décembre 2020, we consulted 1108 pediatric surgery patients and performed 805 surgical procedures including 76 umbilical hernias. The umbilical hernia has re present 9 .5% of all surgical procedures, 25% of hernias in children 8.3% of hospitalizations and a hospital frequency of 6.8%. The age group of 3 to 6 years was the most represented with 40.3%, the male sex was the most represented with 59%. Conclusion: Umbilical hernia is a frequent pathology, especially in Africa, whose diagnosis is clinical.
Menetrier’s Disease: a Surgical and Pathological Challenge
Authors: Ettahiri Soumeya , Imane Toughrai , Douida Amal , Chbani Laila
Published: February 2022

Menetrier’s disease (MD) is a rare hypertrophic gastropathy clinically characterized by digestive signs as epigastric pain, nausea, vomiting and diarrhea, with hypoalbuminemia and anemia, endoscopically by giant rugal folds and histologically by tortuous foveolar hyperplasia with dilated glands and hypertrophic muscularis mucosae. The current study presents a case of MD in 44 year-old-man admitted to the hospital of Hassan II in Fez, Morocco with epigastralgia, vomiting and weight loss. Physical examination fond a pale face and anemia in laboratory studies. A total gastrectomy was performed given the resistance to treatment and the persistence of symptoms, as well as the suspect endoscopic aspect. Macroscopic examination showed hypertrophic and polyploid gastric mucosa resembles cerebral convolutions. Histological examination showed a foveolar hyperplasia, tortuosity and dilatation of the glands. Hypertrophic muscularis mucosae with smooth muscle bundles extending into the lamina propria have also been observed. MD is considered as precancerous condition, and is associated with an increased risk of gastric cancer. This is a retrospective study of MD to describe his clinical, endoscopic and histological features, showing also the difficulty of the histological diagnosis.
Duodenal Perforation Due to Biliary Stent Migration: Case Report
Authors: Ters Jalila , Eddy Oleko , Moaquit Wadii
Published: February 2022

ERCP is the most commonly used technique to treat biliary stenosis of benign or malignant origin. Duodenal perforations secondary to biliary prostheses are very rare but can be life threatening. Endoscopic retrograde cholangiopancreatography (ERCP) plays an important diagnostic and therapeutic role in the management of biliary and pancreatic disorders. However, it is an invasive procedure with an associated complication rate in the vicinity and mortality. Therapeutic strategies are multiple. We present an unusual case of a patient who sustained a stent-related duodenal perforation after undergoing ERCP whose prognosis was poor.
Bladder Macrolithiasis Complicating Vesical Neck Stenosis, A Rare Cause of Renal Failure: A Case Report
Authors: Allali R. , Ouali R.Ait , Aarab M. , Mortaji A. , Lakmichi M.A. , Dahami Z. , Moudouni M.S. , Sarf I.
Published: February 2022

Bladder lithiasis refers to the disease associated with the formation of stones in the bladder. These stones, which can reach several centimetres in size, are formed from aggregates of various mineral and organic substances. Most often these stones are formed as a result of poor bladder evacuation. We report a case of bladder macrolithiasis associated with two stones: right ureteral and renal on bladder neck stenosis revealed by hypogastric pain and signs of lower urinary tract and complicated by renal failure in a 42 year old patient. The physical examination revealed bilateral lumbar tenderness and a hard hypogastric palpable mass. Imaging revealed the presence of a bladder macrolithiasis occluding almost the entire bladder associated with a pelvic ureter stone and a right renal corraliform stone. The treatment consisted of a suprapubic cystotomy with extraction of the macro bladder stone and the ureteral stone delivered through the meatus by ureterolithotomy with cervical incision of the bladder neck. The postoperative course was simple. The evolution was marked by the normalization of the renal function. The patient underwent a lumbotomy for his right kidney stone 2 months later.
Pengaruh Literacy Financial, Experienced Regret, dan Overconfidence Terhadap Pengambilan Keputusan Investasi Di Pasar Modal
Authors: Budiman Iskandar , Maulana Zefri , Kamal Safwan
Published: February 2022

This study aims to determine the effect of financial literacy, experienced regret, and overconfidence on investment decision making in the capital market. Method of this study was a quantitative approach. This study used nonprobability sampling and determined the number of samples from a population using quota sampling based on certain criteria in accordance with research conducted by researchers. The determined sample was 45 respondents. Respondents criteria were all investors who actively transact at least one day several times a transaction and a maximum of once a month transactions and investors who have experienced adverse events in stock investments such as losses but are still actively transacting. This study used a Likert scale measurement. The results of this study was based on a partial test showing that financial literacy did not affect investment decision making in the capital market, while experienced regret, and overconfidence affect investment decision making in the capital market. The conclusion of this study was based on the analysis of the coefficient of determination (adjusted R2) that 47.3% of the variation in the value of investment decision making in the capital market at IAIN Langsa Investment Gallery was determined by three influential variables, namely financial literacy, experienced regret, and over-confidence. While the remaining 52.7% was explained by other variables not included in the equation above.
FILTRASI BANTARAN SUNGAI, FBS DAN FILTRASI BANTARAN DANAU, FBS/D UNTUK SUMBER DAYA AIR BERKELANJUTAN
Authors:   Institut Sains dan Teknologi Nasional-Jakarta, S. Syafalni , W. Marsino , Kuswaya Wawan
Published: February 2022

Beberapa pengolahan dengan teknologi canggih telah dikembangkan dan diaplikasikan untuk mengolah air yang berkualitas. Tujuan dari teknologi filtrasi bantaran sungai dan danau/situ dalam pengaliran air tersebut meliputi proses adsorpsi, pertukaran ion, filtrasi dan pengolahan melewati lapisan akuifer tanah sehingga menghasilkan air bersih/ minum. Filtrasi bantaran sungai, FBS dan fitrasi bantaran danau/situ, FBD merupakan teknologi yang efisien dan alternatif alami murah untuk memproses air sungai /air permukaan. Selama infiltrasi dan bagian tanah, air permukaan terkena kombinasi fisik, kimia, dan proses biologis seperti filtrasi, pengenceran, penyerapan, dan biodegradasi yang di dapat secara signifikan untuk meningkatkan kualitas air baku untuk kebutuhan air. Pelaksanaan metode ini akan dapat menghindari dampak pencemaran dan penurunan muka air tanah yang pada akhirnya dapat memenuhi permintaan dengan mengintegrasikan pemanfaatan air sungai dan air tanah dangkal. Berdasarkan hasil penelitian untuk area FBS dan FBD didapatkan dengan perencanaan sumur bor pada bantaran sungai dan Situ menunjukkan kualitas air yang didapatkan termasuk air kelas A untuk bantaran Sungai dan Danau/Situ dengan jarak pengambilan adalah 10 meter atau lebih secara vertical dan horizontal, kecuali untuk pH air saat pengambilan.
Complex Value Choices at the Environment-Energy Interface
Authors: Osofsky Hari
Published: February 2022

During the 2001–02 academic year, I lived in China, teaching U.S. civil rights law and helping to start a labor law clinic. My first day of teaching the fall civil rights course was the day of the September 11 attacks, and that event and reactions to it played a dominant role in my experience of that year. However, it was also a particularly interesting year to be in China from an environmental-energy perspective because the Three Gorges Dam was in the process of being built and brought onlie. At that point, the area was partially flooded and it was one of the last years that one could take a standard boat ride through the area. I took a Chinese cruise ship to look at the site—quite an experience that included an almost non-stop speaker directing my daily activities—and also visited the Three Gorges Dam tourist center and a resettled village. I had a number of quiet conversations with people in that village about how the project was affecting their lives. The Three Gorges Dam provides a particularly dramatic example of the complex value choices at the environment-energy interface that are the focus of this essay. In the panel discussion from which this essay emerges, we were asked to assess anthropocentric, biocentric, and ecocentric values at the environment-health interface. However, in the context of the dam, the value conflicts are not found so much in the comparative valuation of humans, species, and ecosystems, but rather in the difficult choices among energy sources that have significant benefits and externalities.
The role of entomophagous in the protection of decorative biodiversity in Absheron
Authors:   Azərbaycan Dövlət Pedaqoji Universiteti biologiya üzrə fəlsəfə doktoru, dosent, Fazil qızı Səfərova Elnurə , Rəsul qızı İsmayilova Zərifə ,   Azərbaycan Dövlət Pedaqoji Universiteti biologiya üzrə fəlsəfə doktoru, baş müəllim
Published: February 2022

Dekorativ biomüxtəliflik Abşeron rayonunun yaşayış məntəqələrini, o cümlədən bağları, parkları və digər memarlıq görünüşünü bəzəyir. Dekorativ biomüxtəlifliyin qorunması dinindən, irqindən, tutduğu mövqedən asılı olmayaraq hər bir vətəndaşın borcudur. Abşeron yarımadasında müxtəlif növdə və sayda dekorativ ağac və kol bitkiləri əkilib becərilir ki, bu da heç şübhəsiz insanların istirahətinə, ekoloji cəhətdən havanın təmizliyinə, şəhər və qəsəbələrin abadlaşmasına xidmət edir. Azərbaycanda, o cümlədən Abşeron yarımadasında aparılan yaşıllaşdırma işləri son illər daha geniş vüsət alır. Buna baxmayaraq bu bitkilər mütamadi olaraq zərərvericilər tərəfindən məhv edilir. Kimyəvi mübarizə üsulları insan və ətraf aləm üçün təhlükəli, zərərvericinin parazit və yırtıcıları (entomofaqları) vasitəsilə təbii mübarizə tədbirlərinə isə az üstünlük verilir. Ciddi zərərvericilərə qarşı bioloji mübarizədə insan sağlamlığına zərər vermədən perspektiv entomofaqlardan istifadə etmək daha məqsədəuyğundur. Dekorativ bitkilərin zərərvericilərinə qarşı entomofaqlardan istifadə edərək həm zərərvericilərin sayını azaltmış oluruq, həm də ətraf mühitin çirklənməsinin qarşısının alınması və ərzaq təhlükəsizliyinin təmin edirik. Məqalədə bir neçə entomofaqın daha perspektivli olduğunu vurğulayaraq onlar haqqında məlumat verilib. Açar sözlər: zərərverici, entomofaq, dekorativ, ekologiya, bitki Elnura Fazil Safarova Zarifa Rasul Ismayilova The role of entomophagous in the protection of decorative biodiversity in Absheron Abstract Decorative biodiversity Absheron region settlements, including decorating gardens, parks and other architectural views. The protection of decorative biodiversity is the duty of every citizen, regardless of religion, race or position. Various types and number of ornamental trees and shrubs are planted on the Absheron Peninsula, which undoubtedly serves the recreation of people, ecologically clean air, improvement of cities and settlements. Landscaping work in Azerbaijan, including the Absheron Peninsula, has been expanding in recent years. However, these plants are regularly destroyed by pests. Chemical control methods are dangerous to humans and the environment, and natural control measures by parasites and predators (entomophagous) are less preferred. In the biological control of serious pests, it is more expedient to use promising entomophagous without harm to human health. By using entomophagous pests of ornamental plants, we both reduce the number of pests and prevent environmental pollution and ensure food security. The article emphasizes that several entomophagous are more promising. Кеу words: pest, entomophag, dekorativ, ecology, plant
MULTIDISCIPLINARY APPROACH TO MANAGEMENT OF PEDIATRIC PATIENTS WITH SKIN SYMPTOMS OF FOOD ALLERGY
Authors: Besh Lesya , Matsyura Oksana , Gutor Taras , Nahurna Yaryna , Kovalska Oksana , Lukyanenko Natalia
Published: February 2022

The aim: To determine the significance of multidisciplinary approach to management of pediatric patients with skin symptoms of food allergy.
Materials and methods: The study included of 36 patients aged 4 to 6 years with skin manifestations of food allergy, of which 18 were randomly included in the study group and had a multidisciplinary approach to treatment and the other 18 patients constituted a comparison group and used a standard therapy regimen. Observation of children was carried out for 3 months.
Results: Assessment of the severity of the cutaneous form of food allergy by SCORAD score showed the average degree of disease activity in the groups of the study at the beginning of treatment and significantly better dynamics in patients of the study group (p=0.0055). In 88.9% (n=16) of patients in the study group and 61.1% (n=11) of the control group, the process became mild.
Conclusions: The application of a multidisciplinary approach allows the integrated implementation of medical, nutritional, and psychological aspects, which significantly increases the effectiveness of treatment and improves the quality of life of patients and their parents.
CYTOKINOGENESIS DISORDERS IN MECHANISMS OF THE EXPERIMENTAL PERODONTITIS DEVELOPMENT AND THEIR CORRECTION BY FLAVONOL
Authors: Demkovych Andrii , Bondarenko Yurii , Hasiuk Petro , Denefil Olha , Zubchenko Serhii , Kalashnikov Dmytro
Published: February 2022

The aim: Evaluation of changes in proinflammatory and anti-inflammatory units of the cytokine profile in the mechanisms of development of experimental bacterial-immune periodontitis and elucidation of the effect of flavonol quercetin on its parameters.
Materials and methods: Experimental periodontitis was caused by introducing into the tissues of the periodontal complex a mixture of microorganisms diluted with egg protein. In order to enhance the immune response, a complete Freund’s adjuvant was injected into the rat’s paw at the same time. For correction, intramuscular injections of water-soluble quercetin at a dose of 100 mg / kg body weight were performed for 7 days (7th to 14th day).
Results: The use of flavonol quercetin led to a decrease in the serum content of experimental animals with pro-inflammatory cytokines. With regard to anti-inflammatory cytokines, their content in the blood of animals during the development of this simulated inflammatory process changed in the opposite direction. Quercetin effectively eliminated the imbalance of the immune system and increased the level of IL-10 and IL-4 in the serum. After injections of quercetin, the relation of pro- and anti-inflammatory cytokines in the serum of animals on 14th day of the study was reduced compared to their content in rats that did not receive correction.
Conclusions: The formation and course of experimental bacterial-immune periodontitis is accompanied by a complex of pathological changes in immunocytokinogenesis, which is manifested by a progressive increase in serum concentrations of proinflammatory cytokines and a decrease in anti-inflammatory cytokines. Flavonol quercetin reduces the concentration of pro-inflammatory and increases the content of anti-inflammatory cytokines.
PROGNOSTIC SIGNIFICANCE OF METABOLISM INDICATORS OF CONNECTIVE TISSUE IN PATIENTS WITH UPPER URINARY TRACT OBSTRUCTION
Authors: Pavlov Sergey B. , Savenkov Vladimir I. , Khvysyuk Oleksandr M. , Karabut Larysa V. , Pavlova Galina B.
Published: February 2022

The aim: The aim of the study was a comparative analysis of indicators characterizing the state of connective tissue in patients with hydronephrosis due to upper urinary tract obstruction, with the presence and absence of recurrence after surgery.
Materials and methods: Levels of free and bound hydroxyproline, as well as the key mediator of fibrogenesis transforming growth factor-β1 in serum of patients with congenital and acquired obstructions were determined. Ratio peptide-bound and free hydroxyproline were calculated. Groups were divided according to the presence or absence of recurrence of the stricture for a period of 4.5 years after surgery.
Results: Imbalance of the destructive and synthetic processes in extracellular matrix of connective tissue that is characterized by a higher content of fractions of hydroxyproline and transforming growth factor-β1 in the serum were identified. It is shown that the most pronounced changes are observed in patients with relapsing. In patients with a congenital obstruction and a recurrent course of the disease, the highest activation of the collagen metabolism was observed, which was evidenced by the high levels peptide-bound and protein-bound hydroxyproline, relative to these indicators in patients with acquired obstruction (as with the presence and absence of relapses).
Conclusions: The increase in the ratio of peptide-bound/free hydroxyproline and the level of transforming growth factor-β1 in the blood of patients with stage II-III hydronephrosis on the 21st day after surgery may be a prognostic marker for the development of disease recurrence.
SUGGESTIONS AND PRESCRIPTIONS FOR MAINTAINING GOOD HEALTH IN «REGIMEN SANITATIS SALERNI» BY ARNOLD OF VILLANOVA
Authors: Zahaiska Halina M. , Petryshyn Marta J. , Liubimova Oxana V.
Published: February 2022

The aim: The aim of the study is collection, systematization and comprehensive analysis of suggestions and prescriptions for maintaining good health set forth by Arnold of Villanova in “Regimen Sanitatis Salerni”.
Materials and methods: The research is based on the first edition of “The Salernitan Rule of Health” (1479) by Arnold of Villanova that comprises 364 poems (103 chapters). In this investigation we consciously leave some later editions of the “Rule” unattended since they contain insertions that do not belong to the author.
Conclusions: Sanitary and hygiene suggestions, therapeutic practices, proper nutrition principles, analysis of influence of animal and plant products on the human body, prescriptions for medicinal plants administration are not merely a pathway to salubrity but also basic standards of sanitary and epidemic well-being. The medieval treatise has provided the underlying framework for modern dietology and healthy lifestyle.
CLINICAL CASE OF NEUROMYELITIS OPTICA SPECTRUM DISORDERS IN YOUNG WOMAN TREATED WITH RITUXIMAB
Authors: Poiasnyk Iryna M. , Gryb Viktoriia A.
Published: February 2022

We report a case of a 28-year-old female who had the clinical manifestation of Neuromyelitis optica spectrum disorders with the area postrema syndrome at 24 years old. The patient presented with decreased vision due to acute optic neuritis, gait impairment, tetraplegia, sensory, and bladder disturbances. Magnetic resonance imaging of the spinal cord showed longitudinal high-intensity signals on a T2-weighted image in cervical and thoracic parts. Her serum and cerebrospinal fluid were positive for the anti-AQP4 antibody. The patient received high-dose methylprednisolone, plasmapheresis, but she remained free from relapses only after prescribing Rituximab.
Prophylactic treatment of Neuromyelitis optica spectrum disorders recurrence must be immediately performed when it is identified because the progression of disability is related to the severity of attacks.