bluuebunny/crossref_metadata_2025 huggingface dataset:
Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy
Authors: Kerckhove Nicolas , Selvy Marie , Lambert Céline , Gonneau Coralie , Feydel Gabrielle , Pétorin Caroline , Vimal-Baguet Agnès , Melnikov Sergey , Kullab Sharif , Hebbar Mohamed , Bouché Olivier , Slimano Florian , Bourgeois Vincent , Lebrun-Ly Valérie , Thuillier Frédéric , Mazard Thibault , Tavan David , Benmammar Kheir Eddine , Monange Brigitte , Ramdani Mohamed , Péré-Vergé Denis , Huet-Penz Floriane , Bedjaoui Ahmed , Genty Florent , Leyronnas Cécile , Busserolles Jérôme , Trévis Sophie , Pinon Vincent , Pezet Denis , Balayssac David
Published: November 2021

Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients’ characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management.
The Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity
Authors: Fu Ke , Wang Cheng , Ma Cheng , Zhou Honglin , Li Yunxia
Published: November 2021

Liver diseases have been a common challenge for people all over the world, which threatens the quality of life and safety of hundreds of millions of patients. China is a major country with liver diseases. Metabolic associated fatty liver disease, hepatitis B virus and alcoholic liver disease are the three most common liver diseases in our country, and the number of patients with liver cancer is increasing. Therefore, finding effective drugs to treat liver disease has become an urgent task. Chinese medicine (CM) has the advantages of low cost, high safety, and various biological activities, which is an important factor for the prevention and treatment of liver diseases. This review systematically summarizes the potential of CM in the treatment of liver diseases, showing that CM can alleviate liver diseases by regulating lipid metabolism, bile acid metabolism, immune function, and gut microbiota, as well as exerting anti-liver injury, anti-oxidation, and anti-hepatitis virus effects. Among them, Keap1/Nrf2, TGF-β/SMADS, p38 MAPK, NF-κB/IκBα, NF-κB-NLRP3, PI3K/Akt, TLR4-MyD88-NF-κB and IL-6/STAT3 signaling pathways are mainly involved. In conclusion, CM is very likely to be a potential candidate for liver disease treatment based on modern phytochemistry, pharmacology, and genomeproteomics, which needs more clinical trials to further clarify its importance in the treatment of liver diseases.
Learning-Based Image Transport Through Disordered Optical Fibers With Transverse Anderson Localization
Authors: Zhao Jian , Hu Xiaowen , Gausmann Stefan , Antonio-Lopez Jose Enrique , Correa Rodrigo Amezcua , Schülzgen Axel
Published: November 2021

Fiber-optic imaging systems play a unique role in biomedical imaging and clinical practice due to their flexibilities of performing imaging deep into tissues and organs with minimized penetration damage. Their imaging performance is often limited by the waveguide mode properties of conventional optical fibers and the image reconstruction method, which restrains the enhancement of imaging quality, transport robustness, system size, and illumination compatibility. The emerging disordered Anderson localizing optical fibers circumvent these difficulties by their intriguing properties of the transverse Anderson localization of light, such as single-mode-like behavior, wavelength independence, and high mode density. To go beyond the performance limit of conventional system, there is a growing interest in integrating the disordered Anderson localizing optical fiber with deep learning algorithms. Novel imaging platforms based on this concept have been explored recently to make the best of Anderson localization fibers. Here, we review recent developments of Anderson localizing optical fibers and focus on the latest progress in deep-learning-based imaging applications using these fibers.
Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes
Authors: Thuptimdang Wanwara , Shah Payal , Khaleel Maha , Sunwoo John , Veluswamy Saranya , Kato Roberta M. , Coates Thomas D. , Khoo Michael C. K.
Published: November 2021

Recent studies have shown that individuals with sickle cell disease (SCD) exhibit greater vasoconstriction responses to physical autonomic stressors, such as heat pain and cold pain than normal individuals, but this is not the case for mental stress (MTS). We sought to determine whether this anomalous finding for MTS is related to inter-group differences in baseline cardiac and vascular autonomic function. Fifteen subjects with SCD and 15 healthy volunteers participated in three MTS tasks: N-back, Stroop, and pain anticipation (PA). R–R interval (RRI), arterial blood pressure and finger photoplethysmogram (PPG) were continuously monitored before and during these MTS tasks. The magnitude of vasoconstriction was quantified using change in PPG amplitude (PPGa) from the baseline period. To represent basal autonomic function, we assessed both cardiac and vascular arms of the baroreflex during the baseline period. Cardiac baroreflex sensitivity (BRSc) was estimated by applying both the “sequence” and “spectral” techniques to beat-to-beat measurements of systolic blood pressure and RRIs. The vascular baroreflex sensitivity (BRSv) was quantified using the same approaches, modified for application to beat-to-beat diastolic blood pressure and PPGa measurements. Baseline BRSc was not different between SCD and non-SCD subjects, was not correlated with BRSv, and was not associated with the vasoconstriction responses to MTS tasks. BRSv in both groups was correlated with mean PPGa, and since both baseline PPGa and BRSv were lower in SCD, these results suggested that the SCD subjects were in a basal state of higher sympathetically mediated vascular tone. In both groups, baseline BRSv was positively correlated with the vasoconstriction responses to N-back, Stroop, and PA. After adjusting for differences in BRSv within and between groups, we found no difference in the vasoconstriction responses to all three mental tasks between SCD and non-SCD subjects. The implications of these findings are significant in subjects with SCD since vasoconstriction reduces microvascular flow and prolongs capillary transit time, increasing the likelihood for vaso-occlusive crisis (VOC) to be triggered by exposure to stressful events.
Mode Switch of Ca2 + Oscillation-Mediated Uterine Peristalsis and Associated Embryo Implantation Impairments in Mouse Adenomyosis
Authors: Qu Mingzi , Lu Ping , Bellve Karl , Lifshitz Lawrence M. , ZhuGe Ronghua
Published: November 2021

Adenomyosis is a debilitating gynecological disease of the uterus with no medicinal cure. The tissue injury and repair hypothesis for adenomyosis suggests that uterine hyperperistalsis or dysperistalsis plays a pivotal role in establishing adenomyotic lesions. However, specific impairments in uterine peristalsis and the underlying cellular signals for these changes in adenomyosis remain elusive. Here, we report a precision-cut uterine slice preparation that preserves in vivo uterine architecture and generates peristalsis similar to that seen in the whole uterus. We found that uterine peristalsis in neonatal mice at day 14 and adult mice at day 55 presents as bursts with multiple peaks induced by intracellular Ca2+ oscillations. Using a mouse model of adenomyosis induced by tamoxifen, a selective estrogen receptor modulator, we discovered that uterine peristalsis and Ca2+ oscillations from adenomyotic uteri on days 14 and 55 become spikes (single peaks) with smaller amplitudes. The peak frequency of Ca2+ oscillations or peristalsis does not show a difference between control and adenomyotic mice. However, both the estimated force generated by uterine peristalsis and the total Ca2+ raised by Ca2+ oscillations are smaller in uteri from adenomyotic mice. Uteri from adenomyotic mice on day 14, but not on day 55, exhibit hyperresponsiveness to oxytocin. Embryo implantations are decreased in adenomyotic adult mice. Our results reveal a mode switch from bursts to spikes (rather than an increased peak frequency) of uterine Ca2+ oscillations and peristalsis and concurrent hyperresponsiveness to oxytocin in the neonatal stage are two characteristics of adenomyosis. These characteristics may contribute to embryo implantation impairments and decreased fertility in adenomyosis.
2-Keto-L-Gulonic Acid Improved the Salt Stress Resistance of Non-heading Chinese Cabbage by Increasing L-Ascorbic Acid Accumulation
Authors: Gao Mingfu , Sun Hao , Shi Meijun , Wu Qiqi , Ji Dongxu , Wang Bing , Zhang Lixin , Liu Yang , Han Litao , Ruan Xicheng , Xu Hui , Yang Weichao
Published: November 2021

Salt stress has long been a prominent obstacle that restricts crop growth, and increasing the L-ascorbic acid (ASA) content of crops is an effective means of alleviating this stress. 2-Keto-L-gulonic acid (2KGA) is a precursor used in industrial ASA production as well as an ASA degradation product in plants. However, to date, no study has investigated the effects of 2KGA on ASA metabolism and salt stress. Here, we evaluated the potential of using 2KGA to improve crop resistance to salt stress (100mM NaCl) through a cultivation experiment of non-heading Chinese cabbage (Brassica campestris ssp. chinensis). The results showed that the leaf and root biomass were significantly improved by 2KGA application. The levels of metabolites and enzymes related to stress resistance were increased, whereas the hydrogen peroxide (H2O2) and malondialdehyde (MDA) contents were decreased. Lipid peroxidation and cell membrane damage were alleviated following 2KGA treatment. Positive correlations were found between photosynthetic pigments and organic solutes, ASA and photosynthetic pigments, and ASA and antioxidant enzymes. In contrast, negative correlations were observed between antioxidant enzymes and H2O2/MDA. Moreover, the expression levels of L-gulono-1,4-lactone oxidase, GDP-mannose pyrophosphorylase, dehydroascorbate reductase-3, and ascorbate peroxidase were increased by 2KGA treatment. These results suggested that exogenous 2KGA application can relieve the inhibitory effect of salt stress on plant growth, and the promotion of ASA synthesis may represent a critical underlying mechanism. Our findings have significant implications for the future application of 2KGA or its fermentation residue in agriculture.
Improving Firm’s Economic and Environmental Performance Through the Sustainable and Innovative Environment: Evidence From an Emerging Economy
Authors: Ahmad Naveed , Scholz Miklas , AlDhaen Esra , Ullah Zia , Scholz Philippa
Published: November 2021

Businesses in the present era are dealing with a complex and unprecedented brew of social, environmental, and technological trends. This requires sophisticated, sustainability-based management. Yet organizations are often reluctant to place sustainability core to their business strategies with the mistaken belief that the costs associated with environmental investments outweigh the benefits. The Global Climate Risk Index has placed Pakistan on 5th position in the list of nations, most susceptible to climate change in its recent report. Pakistan lost the lives of 9,989 people, incurred economic losses of $ 3.8 billion, and faced 152 shocking climates between 1999 and 2018. Based on this information, it is established that Pakistan’s susceptibility to climate change is growing unprecedentedly and industrial pollution is one of the biggest contributors in this respect. The country needs to take emergency measures to address this issue. With this background, the present study aims to investigate the impact of environmental sustainability on environmental and economic performance (EP) with the mediating effect of environmental innovation (EI) in the manufacturing sector of Pakistan. The results show that environmental sustainability is a significant predictor of environmental performance and EP and EI mediates this relationship. The findings of the present study provide better insights to policymakers to address the environmental degradation, resulting from industrial pollution.
The Paths to Connectedness: A Review of the Antecedents of Connectedness to Nature
Authors: Lengieza Michael L. , Swim Janet K.
Published: November 2021

Although many philosophers and environmental psychologists agree that progress toward a more ecologically conscious society depends upon individuals developing a sense of connectedness to nature, such agreement is of limited use if we do not understand how connectedness forms. The purpose of this review is to delineate the state of the psychological literature concerning the antecedents of connectedness to nature. The literature review is organized into three main sections: (1) situational contexts that influence connectedness; (2) individual difference predictors, such as demographic group membership, personality, or beliefs; and (3) internal psychological states that may explain psychological processes that result in connectedness. Major critiques of the extant literature and future directions are presented in a discussion following the body of the review. The primary implications highlighted by the review are a greater need for theories delineating the formation of connectedness, a greater focus on process, and increased differentiation between similar antecedents of connectedness.
Development of an Instrument to Assess Spirituality: Reliability and Validation of the Attitudes Related to Spirituality Scale (ARES)
Authors: Braghetta Camilla Casaletti , Gorenstein Clarice , Wang Yuan Pang , Martins Camila Bertini , Leão Frederico Camelo , Peres Mario Fernando Prieto , Lucchetti Giancarlo , Vallada Homero
Published: November 2021

Background: Several instruments that measure spirituality present overlaps with positive emotions, impacting the interpretation of their findings. In order to minimize these problems, we aimed to develop, assess the reliability and validate a new scale to evaluate spirituality.

Methods: The instrument was designed using a theoretical framework minimizing tautological issues (i.e., Koenig’s framework), a qualitative study investigating the definitions of spirituality, the development of the first version of instrument by experts’ meetings and a qualitative cognitive debriefing. Then, the instrument was examined for its content validity by a multidisciplinary group of judges and was pilot-tested in two different groups – less religious (medical students – n = 85) and more religious (practicing religious members – n = 85). Finally, psychometric properties and validity were assessed.

Results: The developed Attitudes Related to Spirituality Scale (ARES) is a self-report 11-item instrument using five-level Likert items. ARES presented appropriate psychometric properties revealing excellent internal consistency (alpha = 0.98) and temporal stability (ICC = 0.98). Likewise, ARES was strongly correlated with other validated R/S instruments (i.e., Duke Religion Index and Brief Multidimensional Measure of Religiousness/Spirituality) and was able to discriminate higher and lower religious groups. In the exploratory factor analysis, a unidimensional structure of the scale was described. Fit indices for the scale demonstrated good fit in the unidimensional model.

Conclusion: The ARES is a reliable, valid and stable one-dimension instrument that is appropriate for use in the Portuguese-speaking population.

Descriptors: Spirituality; Scale; Factorial Analysis; Instrument; Measure; Psychometrics.
Translating Psychedelic Therapies From Clinical Trials to Community Clinics: Building Bridges and Addressing Potential Challenges Ahead
Authors: Williams Martin L. , Korevaar Diana , Harvey Renee , Fitzgerald Paul B. , Liknaitzky Paul , O'Carroll Sean , Puspanathan Prashanth , Ross Margaret , Strauss Nigel , Bennett-Levy James
Published: November 2021

Research exploring the potential of psychedelic-assisted therapies to treat a range of mental illnesses is flourishing, after the problematic sociopolitical history of psychedelics led to the shutdown of clinical research for almost 40 years. Encouraged by positive results, clinicians and patients are now hopeful that further interruptions to research will be avoided, so that the early promise of these therapies might be fulfilled. At this early stage of renewed interest, researchers are understandably focusing more on clinical trials to investigate safety and efficacy, than on longer-term goals such as progression to community practice. Looking to identify and avoid potential pitfalls on the path to community clinics, the authors, a group of Australian clinicians and researchers, met to discuss possible obstacles. Five broad categories of challenge were identified: 1) inherent risks; 2) poor clinical practice; 3) inadequate infrastructure; 4) problematic perceptions; and 5) divisive relationships and fractionation of the field. Our analysis led us to propose some strategies, including public sector support of research and training to establish best practice and optimize translation, and funding to address issues of equitable access to treatment. Above all, we believe that strategic planning and professional cohesion will be crucial for success. Accordingly, our key recommendation is the establishment of a multidisciplinary advisory body, broadly endorsed and representing all major stakeholders, to guide policy and implementation of psychedelic-assisted therapies in Australia. Although these challenges and strategies are framed within the Australian context, we sense that they may generalize to other parts of the world. Wherever they apply, we believe that anticipation of potential difficulties, and creative responses to address them, will be important to avoid roadblocks in the future and keep the “psychedelic renaissance” on track.
Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
Authors: Marks Michael , Lal Sham , Brindle Hannah , Gsell Pierre-Stéphane , MacGregor Matthew , Stott Callum , van de Rijdt Martijn , Almazor Guillermo Gutiérrez , Golia Suman , Watson Conall , Diallo Abdourahamane , Toure Alhassane , Houlihan Catherine , Keating Patrick , Martin Hélène , Restrepo Ana-Maria Henao , Anokwa Yaw , Roberts Chrissy H.
Published: November 2021

Background:ODK provides software and standards that are popular solutions for off-grid electronic data collection and has substantial code overlap and interoperability with a number of related software products including CommCare, Enketo, Ona, SurveyCTO, and KoBoToolbox. These tools provide open-source options for off-grid use in public health data collection, management, analysis, and reporting. During the 2018–2020 Ebola epidemic in the North Kivu and Ituri regions of Democratic Republic of Congo, we used these tools to support the DRC Ministère de la Santé RDC and World Health Organization in their efforts to administer an experimental vaccine (VSV-Zebov-GP) as part of their strategy to control the transmission of infection.

Method:New functions were developed to facilitate the use of ODK, Enketo andRin large scale data collection, aggregation, monitoring, and near-real-time analysis during clinical research in health emergencies. We present enhancements to ODK that include a built-in audit-trail, a framework and companion app for biometric registration of ISO/IEC 19794-2 fingerprint templates, enhanced performance features, better scalability for studies featuring millions of data form submissions, increased options for parallelization of research projects, and pipelines for automated management and analysis of data. We also developed novel encryption protocols for enhanced web-form security in Enketo.

Results:Against the backdrop of a complex and challenging epidemic response, our enhanced platform of open tools was used to collect and manage data from more than 280,000 eligible study participants who received VSV-Zebov-GP under informed consent. These data were used to determine whether the VSV-Zebov-GP was safe and effective and to guide daily field operations.

Conclusions:We present open-source developments that make electronic data management during clinical research and health emergencies more viable and robust. These developments will also enhance and expand the functionality of a diverse range of data collection platforms that are based on the ODK software and standards.
Contracting Out National Immunization Program Does Not Improve Vaccination Rate Nor Socioeconomic Inequality: A Case Study of Seasonal Influenza Vaccination in South Korea
Authors: Moon Daseul , Kim Saerom , Kim Myoung-Hee , Jeong Dawoon , Choi Hongjo
Published: November 2021

The objective of the present study was to investigate if the policy for contracting out the Korean influenza National Immunization Program (NIP) for individuals aged ≥ 65 years affects a reduction in vaccination inequality based on gender and socioeconomic position (SEP). In South Korea, initially only public health centers provided influenza vaccination for free; however, starting from the fall of 2015, the program was expanded to include private medical institutions. The policy was expected to improve overall vaccination rate and reduce its inequality, through improving access to vaccination. The present study analyzed how the gap in the vaccination rate changed between before and after contracting out. A multivariate logistic regression model stratified by gender and SEP of individuals aged ≥ 65 years was used. The study also analyzed changes in the unvaccinated rates between before and after contracting out based on an interrupted time series model. The gap in the unvaccinated rate based on SEP present prior to contracting out of the NIP for individuals aged ≥ 65 years did not decrease afterwards. In particular, the step changes were 0.94% (95% confidence interval [CI]: 0.00, 1.89) and 1.34% (95% CI: 1.17, 1.52) in men and women, respectively. In the pre-policy period, among women, the unvaccinated rate of the medical aid beneficiaries group was 1.22-fold higher (95% CI: 1.12, 1.32) than that of the health insurance beneficiaries, and the difference was not reduced post-policy implementation (odds ratio: 1.27, 95% CI: 1.20, 1.36). The findings of the study were that contracting out of the NIP was not effective in improving vaccination rate nor resolving vaccination inequality. Future studies should focus on identifying the mechanism of vaccination inequality and exploring measures for resolving such inequality.
Bacteria Isolated From Milk of Dairy Cows With and Without Clinical Mastitis in Different Regions of Australia and Their AMR Profiles
Authors: Al-harbi Hulayyil , Ranjbar Shahab , Moore Robert J. , Alawneh John I.
Published: November 2021

Mastitis is the most common disease in dairy cattle worldwide. The objectives of this study were to estimate the prevalence of different bacterial species associated with mastitis from dairy herds located in geographically and climatically distinct zones in Australia, and to evaluate the antimicrobial susceptibility of the isolated bacteria. Quarter-level milk samples (n = 419) were collected from 151 mastitis cases and 268 healthy controls originating from 18 dairy herds located in tropical (Northern Queensland), subtropical (Southeast Queensland) and temperate zones (Victoria) between March and June 2019. Milk samples were cultured, and the isolated bacteria were grouped into six groups: Enterobacteriaceae spp.; Streptococcus spp.; Staphylococcus aureus, non-aureus staphylococci (NAS); Bacillus spp.; and Others. Mixed effects conditional logistic regression models were applied to quantify the association between the prevalence of each bacterial group and the herd zone and bulk milk tank somatic cell counts (BMTSCC). Of the 205 isolates, 102 (50%) originated from mastitis cases, and 103 (50%) from controls. Staphylococci were the most prevalent (NAS 32% and S. aureus 11%). Contagious mastitis bacteria were more prevalent in Victoria compared to Queensland dairy herds. NAS species (P < 0.001) were less prevalent in herds with BMTSCC >300,000 cells/mL compared with herds with low BMTSCC ≤150,000 cells/mL. Enterobacteriaceae and Streptococcus spp. groups showed high resistance rates to 1 (51 and 47%, respectively), and 2 (11 and 23%, respectively), antimicrobials. More than one third of the Enterobacteriaceae (48%) and Others (43%) groups spp. were resistant to at least three antimicrobials. This study provided a unique opportunity to investigate the prevalence of mastitis-associated bacteria in clinical cases and in apparently healthy controls. The findings of this study help inform mastitis control and antimicrobial stewardship programs aimed to reduce the prevalence of mastitis and antimicrobial resistance in dairy herds.
Public Attitudes and Concerns about Ammonia as an Energy Vector
Authors: Guati-Rojo Andrea , Demski Christina , Poortinga Wouter , Valera-Medina Agustin
Published: November 2021

Ammonia is gaining popularity around the world due to its advantages as an energy vector over other zero-carbon fuels and has the potential to be a key component for deep decarbonisation of energy systems. However, little is known about public attitudes and concerns about the technology, one of the factors that will determine its successful implementation. This research examined public perception of green ammonia technologies through online surveys conducted in Mexico (n = 563) and the UK (n = 357). The results suggest that most of the participants in the two countries support the development of these technologies, with men being more likely to show support than women. Participants in Mexico and the UK had both negative and neutral associations of ammonia as a chemical, but overall perceptions of green ammonia were surprisingly positive. A multiple regression analysis indicates that support for this technology is highly dependent on the way participants perceive the benefits and the risks of implementing green ammonia as a fuel or for storage in their countries. Perceptions of green ammonia presented in this study must be interpreted cautiously because of the novelty of the concept. Therefore, additional research should be carried out to determine the positive opinion of green ammonia obtained in the research.
Responsible Lending Policy of Green Investments in the Energy Sector in Poland
Authors: Pyka Irena , Nocoń Aleksandra
Published: November 2021

The paper concerns the issue of responsible involvement of commercial banks in Poland in green financing of the energy sector. The main reason for undertaking this topic is the observed increased interest of domestic banks in green financing of investments on the energy market in Poland. Therefore, the main objective are to explore the determinants of changes in the level and structure of bank loans under the influence of green investments in the energy sector in Poland. The article verifies the research hypothesis which assumes that an increase in financing green investments by bank loans in the energy market in Poland requires strengthening the synergy of responsible financing of sustainable development of the economy. For this purpose, a two-stage concept of the empirical research was adopted. On the first stage, questionnaire surveys were conducted among the largest Polish commercial banks to examine the respondents’ acceptance degree of the concept of sustainable financing and greening the loan portfolio. On the second stage, case studies were analyzed along with the analysis of selected secondary quantitative data. It was proven that commercial banks in Poland increase their commitment to sustainable financing, which is observed in the sectorally progressing process of “greening” the credit offer. There is also a noticeable change in their approach to social responsibility, especially in the context of the energy market, where financing of traditional, ecologically harmful projects is still dominant. However, this trend is slowly being reversed, towards supporting investments in the area of modern, environmentally-friendly energy solutions. However, “greening” of loan portfolios in the native banking sector requires a responsible lending policy based on various complex business decisions. Increasing their pro-ecological awareness of financing the economy is only a prerequisite, albeit inadequate, of further energy transformation in Poland.
The Influence Catalyst Layer Thickness on Resistance Contributions of PEMFC Determined by Electrochemical Impedance Spectroscopy
Authors: Grandi Maximilian , Mayer Kurt , Gatalo Matija , Kapun Gregor , Ruiz-Zepeda Francisco , Marius Bernhard , Gaberšček Miran , Hacker Viktor
Published: November 2021

Electrochemical impedance spectroscopy is an important tool for fuel-cell analysis and monitoring. This study focuses on the low-AC frequencies (2–0.1 Hz) to show that the thickness of the catalyst layer significantly influences the overall resistance of the cell. By combining known models, a new equivalent circuit model was generated. The new model is able to simulate the impedance signal in the complete frequency spectrum of 105–10−2 Hz, usually used in experimental work on polymer electrolyte fuel cells (PEMFCs). The model was compared with experimental data and to an older model from the literature for verification. The electrochemical impedance spectra recorded on different MEAs with cathode catalyst layer thicknesses of approx. 5 and 12 µm show the appearance of a third semicircle in the low-frequency region that scales with current density. It has been shown that the ohmic resistance contribution (Rmt) of this third semicircle increases with the catalyst layer’s thickness. Furthermore, the electrolyte resistance is shown to decrease with increasing catalyst-layer thickness. The cause of this phenomenon was identified to be increased water retention by thicker catalyst layers.
Full-Order Terminal Sliding-Mode Control of Brushless Doubly Fed Induction Generator for Ship Microgrids
Authors: Zhou Minghao , Su Hongyu , Liu Yi , Cai William , Xu Wei , Wang Dong
Published: November 2021

This paper proposes a full-order terminal sliding-mode (FOTSM) control scheme for brushless doubly fed induction generator (BDFIG)-based islanded microgrids. To deal with mismatched uncertainties in the BDFIG system, virtual control technique-based full-order sliding-mode control is applied to stabilize the amplitude and frequency of terminal voltage. In the current loops, two full-order terminal sliding-mode controllers are designed to make sure that the current tracking errors can reach their equilibrium points in finite time. It is demonstrated by the comprehensive simulations that the proposed method can significantly improve the tracking accuracy, the rapidness, and the robustness to the uncertainties of the BDFIG control system and can enhance the output voltage quality. Furthermore, an experimental study of the proposed control method for BDFIG-based islanded microgrids would be another important future work.
Going for Derivatives or Forwards? Minimizing Cashflow Fluctuations of Electricity Transactions on Power Markets
Authors: Yamada Yuji , Matsumoto Takuji
Published: November 2021

In a competitive electricity market, both electricity retailers and generators predict future prices and volumes and execute electricity delivery contracts through power exchange. In such circumstances, they may suffer from uncertainties caused by fluctuations in spot prices and future demand due to their high volatility. In this study, we develop a unified approach using derivatives and forwards on the spot electricity price and weather data to mitigate the cashflow fluctuation for power utilities. We aim to clarify the applicability of our proposed methods and provide a new and useful perspective on hedging schemes involving various electricity utilities, such as power retailers, solar photovoltaic (PV) generators, and thermal generators. Moreover, we analyze the risk of risk takers (such as the insurance companies in this study) in the derivatives market. In addition, we perform empirical simulations to measure out-of-sample hedging effects on their cashflow management using actual data in Japan.
A New Design Method for Optimal Parameters Setting of PSSs and SVC Damping Controllers to Alleviate Power System Stability Problem
Authors: Farah Anouar , Belazi Akram , Alqunun Khalid , Almalaq Abdulaziz , Alshammari Badr M. , Ben Hamida Mohamed Bechir , Abbassi Rabeh
Published: November 2021

This paper presents an improved Teaching-Learning-Based Optimization (TLBO) for optimal tuning of power system stabilizers (PSSs) and static VAR compensator (SVC)-based controllers. The original TLBO is characterized by easy implementation and is mainly free of control parameters. Unfortunately, TLBO may suffer from population diversity losses in some cases, leading to local optimum and premature convergence. In this study, three approaches are considered for improving the original TLBO (i) randomness improvement, (ii) three new mutation strategies (iii) hyperchaotic perturbation strategy. In the first approach, all random numbers in the original TLBO are substituted by the hyperchaotic map sequence to boost exploration capability. In the second approach, three mutations are carried out to explore a new promising search space. The obtained solution is further improved in the third strategy by implementing a new perturbation equation. The proposed HTLBO was evaluated with 26 test functions. The obtained results show that HTLBO outperforms the TBLO algorithm and some state-of-the-art algorithms in robustness and accuracy in almost all experiments. Moreover, the efficacy of the proposed HTLBO is justified by involving it in the power system stability problem. The results consist of the Integral of Absolute Error (ITAE) and eigenvalue analysis of electromechanical modes demonstrate the superiority and the potential of the proposed HTLBO based PSSs and SVC controllers over a wide range of operating conditions. Besides, the advantage of the proposed coordination design controllers was confirmed by comparing them to PSSs and SVC tuned individually.
Macromodeling High-Speed Circuit Data Using Rational Krylov Fitting Method
Authors: Sahouli Mohamed , Dounavis Anestis
Published: November 2021

This paper presents the modeling of high speed distributed networks characterized by S-parameters frequency data using the rational Krylov fitting (RKFIT) algorithm. Numerical examples illustrate the effectiveness of the method to compute stable rational approximation that fit given S-parameters data. In addition, it is shown that RKFIT has some advantages when compared to the well-established Vector Fitting (VF) method, such as more accurate fitting, less dependence on the choice of the initial poles of the algorithm, and faster convergence. Numerical examples are implemented using RKFIT and the results are compared with VF and the Loewner Matrix (LM) algorithm.
Key Performance Indicators for Evaluation of Commercial Building Retrofits: Shortlisting via an Industry Survey
Authors: Ho Man Ying (Annie) , Lai Joseph H. K. , Hou Huiying (Cynthia) , Zhang Dadi
Published: November 2021

Key performance indicators (KPIs) are quintessentially useful for performance evaluation, but a set of pragmatic KPIs for holistic evaluation of retrofits for commercial buildings is hitherto unavailable. This study was conducted to address this issue. Built upon the findings of a systematic literature review and a focus group meeting in the earlier stages of the study, a questionnaire survey covering 19 KPIs for environmental (embracing energy), economic, health and safety, and users’ perspective evaluations of building retrofits was developed. Data of the survey, collected from facility management (FM) practitioners in Hong Kong, underwent a series of statistical analyses, including Kruskal–Wallis H test, Mann–Whitney U test, and Spearman Rank Correlation. The analysis results revealed the levels of importance of KPIs perceived by different groups of FM practitioners and the rankings of KPIs. Based upon these results, eight KPIs were shortlisted, which are energy savings, payback period, investment cost, actual-to-target ratio of the number of statutory orders removed, actual-to-target ratio of the number of accidents reduced, target indoor air temperature, target indoor air quality (IAQ) class, and target workplane illuminance. These KPIs serve as keystones for further development of an analytic evaluation scheme for commercial building retrofit performance assessment. The methodology of this study can also serve as a reference for similar KPI studies in other research domains.
Building a Competitive Advantage for Indonesia in the Development of the Regional EV Battery Chain
Authors: Konewka Tomasz , Bednarz Joanna , Czuba Tomasz
Published: November 2021

In the process of the electrification of the vehicle industry, an important issue is to adapt production to new technological solutions and to achieve a break-even point in the production costs of an electric vehicle in the short term compared to its traditional counterparts. By the end of 2020, 10 million electric cars were sold worldwide. In today’s globalized and crisis market realities, it is very difficult for state authorities to build a competitive advantage. Based on the concept of M.E. Porter, generating competitiveness does not take place at the macroeconomic, but at the mezzoeconomic level. The key purposes of this review paper are threefold: firstly, to identify the infrastructure for the production of electric cars (market size, resources) in some major Asian countries, including Indonesia; secondly, to identify the importance of FDI for Indonesia and the essence of their relations with China, and thirdly, to investigate whether Indonesia is able to build a competitive advantage in the form of a regional EV battery chain hub. The Indonesian government should ensure a more sizeable investment in lithium-ion battery production in order to complete a whole downstream supply chain, which includes the synthesis of the remaining high-quality battery materials.
Improving Forecast Reliability for Geographically Distributed Photovoltaic Generations
Authors: Kodaira Daisuke , Tsukazaki Kazuki , Kure Taiki , Kondoh Junji
Published: November 2021

Photovoltaic (PV) generation is potentially uncertain. Probabilistic PV generation forecasting methods have been proposed with prediction intervals (PIs) to evaluate the uncertainty quantitively. However, few studies have applied PIs to geographically distributed PVs in a specific area. In this study, a two-step probabilistic forecast scheme is proposed for geographically distributed PV generation forecasting. Each step of the proposed scheme adopts ensemble forecasting based on three different machine-learning methods. When individual PV generation is forecasted, the proposed scheme utilizes surrounding PVs’ past data to train the ensemble forecasting model. In this case study, the proposed scheme was compared with conventional non-multistep forecasting. The proposed scheme improved the reliability of the PIs and deterministic PV forecasting results through 30 days of continuous operation with real data in Japan.
Behavior of XLPE for HVDC Cables under Thermo-Electrical Stress: Experimental Study and Ageing Kinetics Proposal
Authors: Yahyaoui Hanen , Castellon Jerome , Agnel Serge , Hascoat Aurelien , Frelin Wilfried , Moreau Christophe , Hondaa Pierre , Roux Dominique le , Eriksson Virginie , Andersson Carl Johan
Published: November 2021

The present work deals with the study of the electrical behavior of cross-linked polyethylene (XLPE) used for HVDC cable insulation. The aim is to better understand the influences of electrical and thermal stresses on the insulating material in order to provide useful information for designing HVDC cables. This study was carried out on Rogowski samples made of XLPE insulation with semiconductive electrodes, aged for more than 3 years (1220 days) at three different temperatures (70, 80 and 90 °C) under two DC electric fields (30 and 60 kV/mm). Dielectric loss factor, volume resistivity and space charge accumulation were measured. Results are analyzed and cross-correlated, in order to propose possible ageing kinetics.
Implementation and Knowledge of the Clinical Practice Guide for Palliative Care in the Ecuadorian Primary Care Level
Authors: Rodríguez Quintana Tamara , Dávalos-Batallas Viviana , Vargas-Martínez Ana-Magdalena , López Lucelly , Bonilla-Sierra Patricia , Lomas-Campos María-de-las-Mercedes , Leon-Larios Fatima
Published: November 2021

Ecuador assumed the commitment of including Palliative Care (PC) in its health policies. In 2014, the Ministry of Public Health (Ministerio de Salud Pública, MSP) approved the Clinical Practice Guide for Palliative Care (Guía de Práctica Clínica sobre Cuidados Paliativos, GPCCP), with application at the national level, as a mandatory internal regulation in all institutions belonging to the National Health System. In 2021, there is no evidence about the degree of implementation. The objective was to evaluate the implementation (I) of the GPCCP guide and the knowledge (C) of the health personnel working in the Zone 7 Health Centers (HCs). This is a cross-sectional, descriptive, and prospective study. A total of 292 professionals were interviewed: managers (38), physicians (150), and nurses (104). Three surveys based on the GPCCP guide were elaborated: one for the implementation, which was applied to the individuals in charge, and the others to assess the health professionals’ knowledge. The SPSS program was used, version 25. In the three groups, more than half of the participants had no training in PC, 91.2% of the HCs have the GPCCP guide, there is PC medical history (MH) in 38.2%, and morphine is used in 14.7%. The implementation of the GPCCP guide was inadequate in 52.9% of the cases. Only 25% treat the agony symptoms and 30%, delirium; 4.4% acknowledge the use of morphine in dyspnea, and 13.3% identify the subcutaneous route as the first choice for hydration at the end-of-life phase. Strategies to implement the GPCCP guide and to improve the health personnel’s knowledge must be implemented in Zone 7 centers.
Impact of Probiotics on the Performance of Endurance Athletes: A Systematic Review
Authors: Díaz-Jiménez Jara , Sánchez-Sánchez Eduardo , Ordoñez Francisco Javier , Rosety Ignacio , Díaz Antonio Jesús , Rosety-Rodriguez Manuel , Rosety Miguel Ángel , Brenes Francisco
Published: November 2021

Background: Probiotic supplements contain different strains of living microorganisms that promote the health of the host. These dietary supplements are increasingly being used by athletes to improve different aspects such as athletic performance, upper respiratory tract infections (URTIs), the immune system, oxidative stress, gastrointestinal (GI) problems, etc. This study aimed to identify the current evidence on the management of probiotics in endurance athletes and their relationship with sports performance. Methods: A systematic review of the last five years was carried out in PubMed, Scopus, Web of science, Sportdiscus and Embase databases. Results: Nine articles met the quality criteria. Of these, three reported direct benefits on sports performance. The remaining six articles found improvements in the reduction of oxidative stress, increased immune response and decreased incidence of URTIs. There is little scientific evidence on the direct relationship between the administration of probiotics in endurance athletes and sports performance. Conclusions: Benefits were found that probiotics could indirectly influence sports performance by improving other parameters such as the immune system, response to URTIs and decreased oxidative stress, as well as the monitoring of scheduled workouts.
Asymmetric Effects of Quality of Life on Residents’ Satisfaction: Exploring a Newborn Natural Disaster Tourism Destination
Authors: Lin Derong , Jiang Zuoming , Qu Hailin
Published: November 2021

Developing disaster tourism has become an important means of post-disaster recovery, but the relationship between attributes of quality of life (QOL) and residents’ satisfaction toward newborn natural disaster destination (NNDD) development has not been explored. This study examines the asymmetric effects of QOL on residents’ satisfaction using the dummy variable regression approach based on the Three-Factor Theory. A mixed-method approach was used to develop QOL scale, and a questionnaire was developed to survey 379 residents from China’s Wenchuan. This study identifies the types (positive asymmetric, symmetric, and insignificant effect) of seven QOL attributes that influence residents’ satisfaction. This study provides a valuable supplement to the literature on residents’ QOL by focusing on the NNDD context, and is a pioneering attempt to apply the Three-Factor Theory from the perspective of local residents. Practically, some implications for policy optimization are proposed to help NNDD development.
The Association between Korean Clinical Nurses’ Workplace Bullying, Positive Psychological Capital, and Social Support on Burnout
Authors: Bae Seong-Ryeol , Hong Hyon-Joo , Chang Jin-Joo , Shin Sung-Hee
Published: November 2021

Recurring shortages of nursing peoplepower in recent Korean society have impacted nursing organizations with burnout accounting for a major part of nursing staff turnover. Thus, we studied the associations between workplace bullying, positive psychological capital, and social support and whether they predict nursing burnout. We used hierarchical regression analysis to observe changes in influencing factors by sequentially entering general traits, workplace bullying, positive psychological capital, and social support from 166 clinical nurses at two hospitals. The analysis showed that being female (β = 0.18), working three shifts (β = 0.40), workplace bullying (β = 0.24), and positive psychological capital (β = −0.28) were predictors of burnout (F = 11.25, p < 0.001), explaining 44.5% of the variance. An analysis of the correlations between burnout, workplace bullying, positive psychological capital, and social support revealed that workplace bullying was positively correlated with burnout (r = 0.36, p < 0.001), and positive psychological capital (r = −0.49, p < 0.001) and social support (r = −0.37, p < 0.001) were negatively correlated with burnout. Thus, the higher positive psychological capital within an organization, the lower the level of burnout, suggesting that organizations should consider education programs to promote positive psychological capital. In addition, healthy organizational culture should be promoted by monitoring workplace bullying.