bluuebunny/crossref_metadata_2025 huggingface dataset:
Melhoramento genético visando à resistência a mastite em bovinos leiteiros
Authors: Jardim J. G. , Quirino C. R. , Pacheco A. , Lima G. R. S.
Published: May 2017

A mastite caracteriza-se por uma resposta inflamatória na glândula mamária, causada por alterações metabólicas e fisiológicas, traumas, ou mais frequentemente por microrganismos patogênicos ambientais ou contagiosos, cuja rapidez e eficácia de resposta imune do hospedeiro contra o patógeno constituem um fator crucial para o estabelecimento, a persistência e a gravidade da infecção. Estima-se que as perdas econômicas mundiais causadas pela doença podem alcançar 35 bilhões de dólares por ano. Muitos trabalhos foram realizados para identificar e estudar genes envolvidos na resposta de resistência à mastite. Devido ao grande número de vias metabólicas, moléculas e células envolvidas na manifestação da doença, a mastite é uma característica muito complexa, que depende de componentes genéticos e também de fatores ambientais e fisiológicos. A maior parte dos estudos sobre resistência a mastite focaliza o fenótipo de contagem de células somáticas no leite e mastite clínica para inferir sobre o genótipo de resistência. Várias abordagens moleculares são destinadas a incrementar o melhoramento quando os valores de herdabilidade são baixos e a coleta de dados fenotípicos é difícil, por isso esta abordagem tem sido utilizada para seleção de animais resistentes para posterior emprego em programas de melhoramento genético, possibilitando a redução de aplicações de medicamentos com conseqüente redução de custos, dos níveis de contaminação dos produtos e do meio ambiente. Com essa revisão, objetivou-se traçar a trajetória dos estudos sobre as características físicas, ambientais e genéticas de resistência à mastite e assim contribuir para a construção dessa nova concepção no melhoramento genético animal.
Relación entre el consumo de grasas vegetales insaturadas y el contenido de ácidos grasos de la leche de ovejas
Authors: Martínez Marín A. I. , Núñez Sánchez N. , Pavón Vijande R. , Gómez Díaz R. , Peña Blanco F. , García Martínez A.
Published: May 2017

El efecto de la inclusión de aceites y semillas, ricos en ácidos grasos insaturados, en la dieta de ovejas sobre el contenido de ácidos grasos de la grasa láctea se cuantificó mediante metarregresión. Se utilizaron los resultados de 22 trabajos de investigación con un total de 67 tratamientos. Los trabajos se realizaron con 10 razas ovinas europeas y americanas que recibieron dietas con hasta un 7 % de grasa insaturada. Los contenidos de los ácidos grasos saturados de cadena media (AGSCM) mostraron una respuesta lineal negativa al consumo creciente de grasa, que fue más acentuada en el caso del ácido palmítico. Los contenidos del ácido esteárico y de los ácidos grasos insaturados de 18 átomos de carbono (AGI-C18) aumentaron de forma lineal, pero la respuesta fue mayor en los segundos. Los cambios en los AGSCM y AGI-C18 ocasionaron que el índice de aterogenicidad disminuyera linealmente en la grasa láctea. Estos resultados indican que la inclusión de fuentes de grasa ricas en ácidos insaturados en dietas para ovejas ocasiona un cambio favorable en la composición de ácidos grasos de la grasa láctea desde el punto de vista de la salud humana.
El papel de la gestión cooperativa en la mejora del funcionamiento técnico-económico de explotaciones ovinas
Authors: Gaspar P. , Escribano M. , Pulido F. , Rodríguez-Ledesma A. , Mesías F. J. , Pulido A. F.
Published: May 2017

Las explotaciones ovinas en el SO de España se han visto sometidas en los últimos años a distintas presiones, tanto comerciales por los cambios de consumo como políticas por las diversas reformas de la Política Agraria Comunitaria, que se han traducido en procesos de abandono de la actividad o de intensificación para aquellos ganaderos que se han mantenido en el sector. Estos sistemas, no obstante, son enormemente frágiles, además de tener un papel fundamental en la provisión de servicios ambientales. En este contexto se ha estudiado una muestra de 101 explotaciones ovinas pertenecientes a cooperativas y localizadas en el SO de España analizando indicadores de gestión técnica y económica. Se observa que la integración de las explotaciones en estructuras cooperativas puede mejorar las explotaciones y asegurar la persistencia de las mismas gracias a la provisión de servicios adicionales al ganadero, a la generación de valor añadido y a la estabilidad en los precios percibidos.
Caracterización fenotípica del bovino Criollo de Surinam en los distritos de Coronie y Nickerie
Authors: Tjon A San G. G. , Molina-Flores B.
Published: May 2017

El Criollo fue la primera raza bovina introducida en Surinam, pero las descripciones históricas apenas mencionan algunas de sus características fenotípicas. En el presente trabajo, fueron registradas las características fenotípicas de 105 bovinos Criollos de Surinam de diferentes grupos de edad. Las variables cualitativas descritas incluyen el patrón y color de la capa, tamaño y forma de los cuernos, posición y tamaño de la oreja, presencia y tamaño de morrillo o joroba y de la papada. Los valores cuantitativos incluyen el perímetro torácico, longitud escapulo-isquial, alzada a la cruz, longitud de la cara, longitud de la oreja, longitud del cuerno y el peso corporal. La mayoría de los datos obtenidos de los animales muestreados fueron bastante consistentes con las descripciones históricas, con la excepción de la enorme variación observada en el patrón y color de la capa, la desaparición total de la joroba y un ligero aumento del peso corporal.
Frecuencias genotípicas y alélicas de la b-caseína en el bovino Criollo Lechero Tropical de México
Authors: Duifhuis Rivera T. , Ayala Valdovinos M. A. , Alonso Morales R. A. , Gayosso Vázquez A. , Rosendo Ponce A. , Becerril Pérez C. M.
Published: May 2017

El objetivo de este estudio fue estimar las frecuencias genotípicas y alélicas de las variantes A1 y A2 de la b-caseína y determinar su relación con la producción de leche por lactancia (PL305) en el bovino Criollo Lechero Tropical (CLT). Se recolectaron muestras de sangre de 151 hembras; a partir del ADN un segmento del gen de la b--caseína se amplifico por PCR y se genotipificó por digestión con endonucleasa de restricción. Las frecuencias genotípicas para A1A1, A1A2 y A2A2 fueron 0,09, 0,78 y 0,13 (p£0,05) y las frecuencias alélicas para A1 y A2 fueron 0,48 y 0,52 (p>0,05). Las frecuencias genotípicas y alélicas de la b-caseína en el ganado CLT fueron similares a la raza Holstein. No se presentó efecto (p>0,05) de los genotipos de la b-caseína en PL305; medias de mínimos cuadrados fueron 1124±93, 1130±152 y 1257±74 para A1A1, A1A2 y A2A2. Continuarán estudios simultáneos de los genotipos para la b-caseína, k-caseína y b-lactoglobulina en la producción y composición de la leche de las vacas CLT.
Viabilidad del caracol terrestre (Cantareus aspersus) durante la época de descanso
Authors: Aragón M. , Angón E. , Rodríguez J. , Barba C. , Perea J. , López M. , Cabello A.
Published: May 2017

Los periodos de estivación e hibernación del caracol son periodos críticos de en la producción helicícola y su conocimiento contribuye decisivamente a la organización productiva y los resultados económicos de las granjas. El objetivo de este estudio fue determinar la evolución del peso vivo y la viabilidad del caracol terrestre (Cantareus aspersus), en condiciones semicontroladas durante el periodo de reposo. La experiencia tuvo una duración de 32 semanas, desde septiembre de 2013 hasta mayo del 2014. Los resultados obtenidos muestran una disminución del peso vivo del 13,57 % y una perdida de la viabilidad en torno al 20 %. Este estudio abre nuevas líneas de investigación orientadas al conocimiento de la fase de hibernación de los caracoles que manejados adecuadamente permite establecer distintas estrategias reproductivas y de manejo en la producción industrial del caracol terrestre C. aspersus.
Realidad aumentada, proyectos en el aula de primaria: experiencias y casos en Ciencias Sociales
Authors: Cozar-Gutiérrez Ramón , Sáez-López José-Manuel
Published: May 2017

La realidad aumentada es un recurso que permite añadir información virtual sobre la realidad, propiciando una aplicación educativa que posibilita una serie de dinámicas e interacciones en el aula. Desde la presente aportación se introduce una integración de esta tecnología en una unidad didáctica en 4º, 5º y 6º de primaria. Se parte de los supuestos pedagógicos de las teorías psicológicas constructivistas, concretamente desde la teoría del aprendizaje significativo y por otra parte los supuestos en aprendizaje colaborativo. Se plantea un proceso centrado en la exploración de figuras a través de la realidad aumentada con dispositivos, trabajo grupal y trabajo centrado en el arte de los pueblos prerromanos, tratando de identificar sus características. Se concluye que este planteamiento aporta un interés, curiosidad y satisfacción al alumnado, potenciando su motivación desde enfoques activos y colaborativos
Massive coagulopathy caused by the bite of a Crotalus basiliscus snake
Authors: Meyer Salome , Hartmann Fabian , Stein Philipp , Lenherr Renato , Fuchs Joan , Spahn Donat R.
Published: May 2017

Crotalus basiliscus (Mexican West Coast Rattlesnake) is a crotalid snake native to Mexico. Whilst there is abundant information on bites by other pit vipers, there is none on the bite of this particular snake. We present the first case report of a bite by Crotalus basiliscus in a 57‐year‐old snake breeder, who after being bitten by one of his largest rattlesnakes, developed shock, a ventricular arrhythmia, profound coagulopathy and signs of compartment syndrome in his left lower extremity. Following repeated administration of antivenom, his clinical condition stabilised, but he required emergency coronary bypass surgery for newly diagnosed severe triple vessel disease.
Transformation and development towards a fully inclusive society and economy in the City of Johannesburg, South Africa
Authors: Kibuuka Paul
Published: May 2017

This paper analyzes the state of economic growth and development in the City of Johannesburg (COJ) South Africa as by the year 2016 and presents a case for transformation and development of the City towards a fully inclusive economy and society. The research reveals that faster and sustainable economic growth in addition to proactive pro-equity policies are a sine qua non for inclusive growth and participation in the City, where the triple challenges of poverty, inequality and unemployment persist more than 20 years into the democratic dispensation. During the last 17 years the City economy has grown at almost the same pace as the national South African economy with a trend reflective of major world economic events. Going forward, the South African economy is projected to grow at less 2% annually in the next 3 years. In terms of the City, the prognosis is that the City will either continue to trace the national economic growth rate or decline from 2% in 2016 to 1% in 2018. In order to achieve the objectives and goals of the Johannesburg 2040 Growth and Development Strategy in the long term and the City Integrated Development Plan in the medium term, the City leadership and administration will need to begin by not only addressing factors that inhibit economic efficiency including crime and corruption, but also the provision of a critical pipeline of skills required by industry in order to attract local and international investment. The increase in investment is expected to broaden the revenue base and to strengthen the financial capacity of the City to roll out services to the previously disadvantaged communities so as to bring them into the mainstream of economic empowerment and social transformation.
Sustainability reporting in the light of corporate social responsibility development: economic and legal issues
Authors: Sukhonos Victor , Makarenko Inna
Published: May 2017

Independent audit assurance of sustainability reporting is the basis for increasing the credibility of the stakeholders, its transparency and reliability; it is a means of implementing legal liability of the company and the evidence of achievement of its legitimacy to the public. The bases for providing such assurance are the standards of implementation of audit tasks in the sphere of sustainable development. Comparative analysis of international practice as for assurance regarding the SR with local realities, based on the reporting database of Ukrainian GRI companies for the 2005-2014 years, witnessed the initial phase of such practices among Ukrainian companies, and the need to strengthen regulatory efforts to determine the legal status of SR auditing standards in Ukraine, ensuring a legal environment and the development of corporate social responsibility initiatives.
Chelation therapy in children
Authors: Krasolnikova M. V.
Published: May 2017

Iron overload (RV) is a condition caused by excessive intake of iron, and in the absence of the specific mechanisms for its excretion - excessive accumulation in tissues and their subsequent lesion leading to functional organ failure [1]. This condition most commonly occurs as a result of regular replacement therapy with erythrocyte mass in the treatment of various anemias. According to statistics, about 500 sick children and 2 000 adults develops post-transfusion RV in Russia in every year [2]. It develops in the context of hereditary anemia (major and intermediate forms of beta-thalassemia, other hemoglobinopathies, severe membrane and enzyme defects, congenital sideroblastic and dyserythropoetic anemia, constitutional hypo- and aplastic anemia) or acquired diseases (acquired aplastic anemia, myelodysplastic syndrome (MDS), myelofibrosis, etc.). [3--5].
Lysosomal lipid storage diseases in children. Modern diagnostic and treatment methods
Authors: Zakharova I. N. , Goryaynova А. N. , Maikova I. D. , Koroid N. V. , Katasonova L. P. , Elfimova O. I. , Kuzina N. E. , Dikova E. A.
Published: May 2017

One of the causes of hepatomegaly in children are rare (orphan) diseases associated with congential metabolic disorders. Starting from 2008, the last day of February is Rare Disease Day. As a rule, knowing that the child has a congenital metabolism disorder does not inspire pediatrician's optimism because of poor prognosis and ineffective therapy. However today, new drugs are emerging that can improve the quality of life of patients with orphan diseases. The main target of the pediatrician is timely diagnosis which allows to prescribe replacement enzyme therapy.
Graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in children
Authors: Skvortsova Y. V. , Balashov D. N. , Delyagin V. M.
Published: May 2017

Up to 60 thousand hematopoietic stem cell transplantations (HSCT) are carried out globally all over the world. The outcome of HSCT is largely determined by the probability and severity of the graft-versus-host reaction/disease (GVHD). Treatment involves corticosteroids. Antithymocyte globulin, extracorporeal photopheresis, monoclonal antibodies to interleukins or their receptors, methotrexate, cyclosporine, tacrolimus, sirolimus, antithymocyte globulin, etc. are used in steroid-refractory GVHD. It is worth to mention that mycophenolate mofetil, esther of mycophenolic acid, blocks proliferation of T and B lymphocytes. In patients who are refractory to corticosteroids, the use of mycophenolate mofetil in isolation or in combination with cyclosporine, tacrolimus seems to be justified.
Management of children with acute gastroenteritis in the pediatric district (recommendations of the ESPGHAN-2014)
Authors: Guarino A. , Zakharova I. N. , Sugyan N. G.
Published: May 2017

In 2008, the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) in conjunction with the European Society for Paediatric Infectious Diseases (ESPID) published guidelines for the management of acute gastroenteritis in children [1] (Slide 5). When the new evidence-based data emerged in 2014, the document was updated. [2]
Respiratory mycoplasmosis in pediatrician's practice
Authors: Zaplatnikov A. L. , Maikova I. D. , Lepiseva I. V.
Published: May 2017

Respiratory mycoplasmosis is a group of infectious and inflammatory diseases of the respiratory system caused by pathogenic microorganisms - Mycoplasma species. It was found that the major causative agent is Mycoplasma pneumoniae (M. pneumoniae). The role of other mycoplasma pathogens in the development of respiratory infections still remains a subject of debate. Hence, the term "respiratory mycoplasmosis" is generally associated with M-pneumoniae infection [5, 7, 15, 22].
Effective therapy of atopic dermatitis in children complicated by secondary infection
Authors: Larkova I. A.
Published: May 2017

Atopic dermatitis (AtD) is one of chronic recurrent diseases. One of the most frequent complications of atopic dermatitis in children is secondary bacterial infection which plays a significant role in the pathogenesis of AtD and is a relevant factor for its aggravation. It is recurrent bacterial infection that often causes AtD refractory to standard therapy. Early effective etiotropic treatment of bacterial complications with baneocin is the key to achieving remission of AtD in children.
Clinical and virological characteristics of acute respiratory infections (ARI) with lesions of the larynx in children
Authors: Gasilina E. S. , Polezhaeva N. S. , Matveeva L. P. , Kabanova N. P.
Published: May 2017

The article analyzes the etiological structure of the pathogens and clinical presentation of ARI with lesions of the larynx in children treated in the infectious box at the Samara City Children's Clinical Hospital No.1 named after N.N. Ivanova in the period from 2010 to 2015.
The use of innovative domestic interferon inducer for the prevention and treatment of acute respiratory viral infections in children
Authors: Mizernitskiy Y. L.
Published: May 2017

The article presents data on the place of the modern endogenous interferon inducers in the treatment and prevention of influenza and ARVI in children and the mechanisms of action. The focus is on the domestic antiviral innovation Kagocel which demonstrated high clinical efficacy and safety in a number of multi-center, blind, placebo-controlled studies of the treatment and prevention of ARVI/flu in children over 2 years old.
Rational therapy of asthma in children with inhaled corticosteroids
Authors: Geppe N. A. , Kolosova N. G. , Shatalina S. I.
Published: May 2017

Currently, the most effective drugs for the treatment and management of bronchial asthma (BA) are inhaled corticosteroids (ICS) which, according to global guidelines, are indicated as initial therapy for persistent asthma of any severity.
The specifics of antibiotic therapy in children with acute intestinal infections
Authors: Ruzhentsova T. A. , Ploskireva A. A. , Milyutina L. N. , Gorelov A. V.
Published: May 2017

The article discusses indications for antibiotic treatment and choice of drugs in children with acute enteric infections. Our study demonstrated the efficacy and safety of cefixime, the oral third-generation cephalosporin. The regimen with Pancef (cefixime) oral suspension for children is presented.
Placental apoptosis in pre-eclampsia
Authors: Khovhaeva P. A. , Krasniy A. M. , Tyutyunnik N. V. , Sergunina O. A. , Ganichkina M. B. , Amiraslanov E. Y. , Kan N. E. , Tyutyunnik V. L.
Published: May 2017

The objective was to determine the presence and severity of placental apoptosis in pre-eclampsia. The study included 31 patients. All patients were divided into 2 groups: group I (treatment) included 11 pregnant women with preeclampsia, group II (control) - 20 healthy patients. Gene expression was evaluated with qPCR assay, and placental apoptosis was assessed by the TUNEL method. It was found that the level of placental apoptosis in preeclampsia patients was significantly higher compared to that of apparently healthy females, and in some cases stem villi are destroyed due to programmed cell death in the villous stroma and syncytiotrophoblast. In preeclampsia, oxidative stress leads to increased levels of apoptosis in placental villi. Both trophoblast cells and, in certain cases, cells of the villous stroma are subject to apoptosis.
Corifollitropin alfa. Efficacy, safety and convenience for doctor and patient
Authors: Ablyaeva E. S. , Bendusov I. A.
Published: May 2017

The efficacy and safety of the only existing corifollitropin alpha drug was compared with recombinant follicle stimulating hormone (rFSH) preparations administered for the purpose of stimulating multi-follicular growth under in vitro fertilization/intracytoplasmic sperm injection programmes. According to numerous sources, the efficacy in terms of live birth rates, clinical and ongoing pregnancy among female patients receiving corifollitropin alpha and those receiving rFSH during the first 7 days of stimulation was comparable. There were no statistical differences between the corifollitropin alfa and rFSH groups in terms of the incidence of ectopic and multiple pregnancy, risk of OHSS, embryonal/fetal malformations. The rate of antibody formation to corifollitropinu alpha was not clinically relevant. There were statistical differences in ovarian response between the groups of patients receiving corifollitropin alpha and patients taking rFSH reflected in a higher number of cumulus oocyte complexes in the corifollitropin alpha group. Patients demonstrated higher satisfaction after receiving corifollitropin alpha compared to rFSH due to a lower number of injections required.
Immunomodulatory drugs in the treatment of postpartum endometritis
Authors: Tyutyunnik V. L. , Kan N. E. , Veresova A. A. , Amiraslanov E. Y.
Published: May 2017

Puerperium pyoinflammatory diseases (PID) represent the most crucial problem in obstetrics. Among the PID pathologies, the leading place belongs to postpartum endometritis, most commonly occurring after surgical and pathological childbirth. Given the fact that in the pathogenesis of postpartum PID the significant role belongs to changes in the immunological status characterized either by the combined inhibition of T- and B-systems of immunity or, primarily, by damage to T-lymphocytes, the inclusion of immunomodulatory drugs in the complex therapy of postpartum endometritis contributes to a more rapid achievement of clinical effect and allows to obtain favorable outcomes.
Aspectos da impenhorabilidade da pequena propriedade rural e o desenvolvimento rural: garantia constitucional da agriculta familiar
Authors: Hammes Elia Denise , Deponti Cidonea Machado
Published: May 2017

O objetivo do presente artigo é analisar a abertura da agricultura familiar para o mercado, e diante dessa realidade verificar a importância da garantia constitucional da impenhorabilidade da pequena propriedade rural, além de atentar para importantes aspectos da interpretação do Poder Judiciário. No que se refere às questões metodológicas deste artigo, realizou-se uma pesquisa documental, juntamente com uma análise analítico-descritiva baseada em dados secundários como leis, jurisprudências colhidos em sites governamentais. A Constituição Federal de 1988, de forma inédita, estabeleceu a pequena propriedade rural, desde que trabalhada pela família, como bem absolutamente impenhorável para débitos gerados em decorrência de sua atividade produtiva. Verificou-se a importância da agricultura familiar para o país e demonstrou-se que o Judiciário em suas instâncias vem, em regra, participando da manutenção do agricultor familiar na pequena propriedade rural, sem perdê-la em favor de débitos constituídos em face de sua atividade produtiva, aplicando não só os ditames constitucionais, mas também a legislação infraconstitucional.
Contribuições dos Serviços de Extensão Rural em Assentamentos da Reforma Agrária no RS: Uma Leitura a Partir da Agroindustrialização como Estratégia de Acesso aos Mercados
Authors: Deon Paulo Roberto Cecconi , Neumann Pedro Selvino
Published: May 2017

Este artigo aborda as interações entre os serviços de extensão rural e agricultores em assentamentos da reforma agrária no intuito de encontrar alternativas para a reprodução das famílias. Para tanto, busca-se analisar as contribuições e limitações da ação extensionista em processos desencadeados por projetos de agroindustrialização (moinhos coloniais) em assentamentos rurais no RS. O problema se configura pela demanda de conhecimentos específicos (e por isso inovadores) dos agricultores e dos serviços de ATES, e pela frustração de expectativas, desconfiança e falta de adesão por parte dos beneficiários em potencial. A partir de metodologia qualitativa (estudo de caso, fontes primárias), foi possível apontar inovações relacionadas ao produto, aos processos, inovações organizacionais, além de inovações no sistema de assessoramento rural. Contudo, após repetidas intervenções, os moinhos coloniais ainda permaneciam com pouca autonomia. Os resultados sugerem limites não só da atividade como estratégia de acesso aos mercados, mas dos próprios serviços de extensão que pouco avançam no sentido de desvincular-se da alcunha ‘assistencialista’.
Cooperação alternativa como estratégia de viabilização da agricultura familiar: o caso da Cooperativa Central Sabor Colonial
Authors: Kunzler Lauri Luiz , Badalotti Rosana Maria
Published: May 2017

O processo modernizador que consolidou a região Oeste de Santa Catarina como polo produtor de commodities alimentares foi, ao mesmo tempo, extremamente rigoroso na seleção dos integrados às cadeias produtivas, o que resultou na exclusão de milhares de agricultores das possibilidades de inserção econômica e reprodução social e em contramovimentos que têm constituído modos alternativos de agregação de valor e cooperação à agricultura familiar. O foco do presente estudo é a analise das estratégias de desenvolvimento rural e cooperação para a viabilização da agricultura familiar a partir da atuação da Cooperativa Central Sabor Colonial. A pesquisa se caracteriza como estudo de caso exploratório descritivo, com abordagem qualitativa. Para a obtenção dos dados, além de pesquisa bibliográfica e documental, foram realizadas entrevistas semiestruturadas com sujeitos representativos da cooperativa analisada, buscando identificar com maior clareza os limites e as possibilidades de suas estratégias de ação. Constatou-se que a referida cooperativa tem atuação mais dedicada à organização do mercado institucional e, como uma possibilidade em potencial, a capacidade ainda pouco explorada de constituir-se como referência no crescente mercado de produtos diferenciados provenientes da agricultura familiar. Verificou-se também a necessidade de a cooperativa ampliar sua articulação em redes de comercialização mais amplas, de modo a viabilizar novos espaços de comercialização para os empreendimentos de atuação local e, com isso, seguir contribuindo na consolidação da cooperação alternativa como estratégia de reprodução da agricultura familiar.
Intimidade negociada: a percepção dos cuidadores de idosos na perspectiva da economia do care
Authors: Pauli Jandir , Goergen Carla , Goldoni Elisa Helena
Published: May 2017

O objetivo deste estudo é compreender os efeitos das transações monetárias na relação entre idosos e seus cuidadores. A partir desse propósito foi realizada uma pesquisa empírica de caráter qualitativo com cuidadores autônomos ou vinculados a instituições asilares. A orientação teórica teve como base os conceitos de economia do care de Viviana Zelizer (2005), propondo que as relações econômicas são atravessadas pela intimidade, exigindo dos envolvidos um esforço para estabelecer “boas combinações” entre dinheiro e laços afetivos. Os resultados mostram que essas relações, embora funcionem como “arenas de trabalho” na tentativa de ajuste entre intimidade e dinheiro, não podem ser consideradas como “boas combinações” no sentido pleno, uma vez que os cuidadores não fazem a demarcação precisa da função do dinheiro, gerando frustração e indicativos de adoecimento psíquico, uma vez que as exigências de dedicação e altruísmo estão superdimensionadas.
Fungal Anticancer Metabolites: Synthesis Towards Drug Discovery
Authors: Barbero Margherita , Artuso Emma , Prandi Cristina
Published: May 2017

Background:

Fungi are a well-known and valuable source of compounds of therapeutic relevance,
in particular of novel anticancer compounds. Although seldom obtainable through isolation from
the natural source, the total organic synthesis still remains one of the most efficient alternatives to resupply
them. Furthermore, natural product total synthesis is a valuable tool not only for discovery of
new complex biologically active compounds but also for the development of innovative methodologies
in enantioselective organic synthesis.

Methods:

We undertook an in-depth literature searching by using chemical bibliographic databases
(SciFinder, Reaxys) in order to have a comprehensive insight into the wide research field. The literature
has been then screened, refining the obtained results by subject terms focused on both biological activity
and innovative synthetic procedures.

Results:

The literature on fungal metabolites has been recently reviewed and these publications have
been used as a base from which we consider the synthetic feasibility of the most promising compounds,
in terms of anticancer properties and drug development. In this paper, compounds are classified according
to their chemical structure.

Conclusion:

This review summarizes the anticancer potential of fungal metabolites, highlighting the
role of total synthesis outlining the feasibility of innovative synthetic procedures that facilitate the development
of fungal metabolites into drugs that may become a real future perspective. To our knowledge,
this review is the first effort to deal with the total synthesis of these active fungi metabolites and
demonstrates that total chemical synthesis is a fruitful means of yielding fungal derivatives as aided by
recent technological and innovative advancements.
Pemakaian Fine Coarse Aggregate Sebagai Bahan Paving Tahan Aus (Fine Coarse Aggregate Usage As Raw Materials Of Abrasion Resistant Paving)
Authors: Rommel Erwin Rommel
Published: May 2017

Paving blocks are widely used in pavement construction such as container terminals, highways, parking lots, other open areas. Ease of installation, low maintenance and meet of the aestethics aspect cause more paving blocks of preferred. The FCA (fine coarse aggregate) paving blocks has the advantage in a mixture of 1:4:3, which is made by full-pressing method at 100 kg/cm2 with a strength reaches 406 kg/cm2 (grade-1); impact resistance is the best on the mixture of paving the heering-bone pattern. This further research will look at the quality aspects of paving from the abrasion resistance and the absorption rate of FCA paving blocks to provide paving mixture variables in (1; 4; 0, 1; 4; 3, 1; 4; 5) and the amount of pressing (60; 80 and 100 kg/cm2). The research results obtained minimum the abrasion resistance obtained at the paving 1; 4; 3 is given pressing 100 kg/cm2, abrasion value of 0.046 mm / min on a top layer of paving using admixture 1; 2 and 0.089 mm / min on without a top layer of paving blocks. The best absorption levels obtained at the paving with the same composition but at 60 kg/cm2 pressing provision.Key-word :  pressing, strength, abrasion resistance
Konstruksi Pracetak Tahan Gempa Pada Rumah Susun Sewa Sederhana Universitas Muhammadiyah Malang
Authors: Dewi Ratih Sarwendah Komala
Published: May 2017

RUSUNAWA building of Muhammadiyah University of Malang with the precast construction system is much more profitable because the votes faster, cheaper, and efficient compared to the monolithic system construction. To re-planning is done (redesign) include precast components namely plates, beams, columns, and beam-column connection. Planning consists of, one-way reinforced concrete slab with dimensions 4.20m×2.50m×0.07m plus 0.05m is overtopping, reinforced concrete beams for the main beam 0.35m×0.40m and 0.30m×0.40m, column dimensions 0.40m×0.45m, and the connection used is a connection strands with grouting. Quality steel fy=1326Mpa strands, reinforcement quality BJTD screw 40, and fc=K400.The result of the calculation analysis, plates with a thickness of 12 cm consists of precast slab thickness of 7 cm and 5 cm thick overtopping the main reinforcement used D5-200 and the reinforcement for the D4-350, beam and main beam main reinforcement used and the cross bar 4D16 and f10-200mm, the column used and the cross bar reinforcement 6D22 and f10-400 mm. The connection is used, to column with strands 22 mm and length 920 mm, to block the distribution of 400 mm long 4D16. Connections in the grouting using Masterflow-95 on the columns and local casted on the beam-plate.Keywords: precast, plate, beams, columns, connections
Hubungan Panjang Seri Data Historik Terhadap Kualitas Data Hasil Prediksi Pada Penerapan Model Rantai Markov Untuk Peramalan Aliran Sungai
Authors: . Sulianto
Published: May 2017

Markov Chain Model is a stochastic model for forecasting the river flow which in his analysis always involves a long series of historical data. In most studies the method is still highly theoretical and not fully applicable significantly due to the limited data in the field.This study is an attempt to optimize the application of Markov Chain Model for its functionality extensively to extrapolate data streams. The scope of this research is basically conducted a study on the relationship between the length of the historical flow data series with data quality prediction results. By knowing these characteristics, the error correction of analysis results can be expected due to data limitations, so that the Markov Chain Model can be widely applied to optimization of waterworks operations.Results for the Konto River and River showed that the prediction of flow Kwayangan next year with Markov chain models tend to give better results than the results of forecasting by conventional methods are widely applied. Markov model is good enough to predict the river flow has low flow fluctuations, but for a river flow fluctuated sharply less than satisfactory results. The length of data series ranges from 15 to 20 of the optimal inputs to produce a minimum error rate prediction. Accuracy of prediction result is not determined by the length of the input data series, but is determined by the nature of statistical data. Value of lag-1 correlation coefficient are large and small skewness coefficient of the historical data tends to give a satisfactory prediction results.Key words: river flow, data, prediktion, markov model.
PENGARUH PENAMBAHAN ‘LIMBAH KARET BAN LUAR’ TERHADAP KARAKTERISTIK MARSHALL PADA LAPIS TIPIS ASPAL PASIR (LATASIR) KELAS B
Authors: Tristianto Andika Budi , Abadi Khoirul
Published: May 2017

Asphalt mixture Latasir called HRSS (Hot Rolled Sand Sheet). Proper aggregate gradation,asphalt latasir distinct class A and class B. A known class Latasir HRSS-A with a nominal minimumthickness of 1.5 cm. As a class known as HRSS Latasir B-B with a nominal minimum thickness of2 cm. Latasir intended for asphalt road with light traffic, especially in areas where coarse aggregateis not available. The use of “rubber tire waste” as asphalt additives latasir is expected to reduce theuse of asphalt and benefits, including increases due to the braking surface traction and reduces tirenoise due to friction with the floor surface. The addition of “waste tire rubber” mixing the asphaltmade with a variety B latasir rubber content of 1%, 2%, 3%, 4% and 5% of the bitumen content. Itis known that a mixture of asphalt latasir B with the addition of “waste rubber tire ‘can improve thequality of Marshal. In the rubber content optimum for the ratio of 0312% rubber content andasphalt content of 7.89%, resulting in a mixture characteristics: Marshall Stability 950 kg, MarshallQuotient 4.1 kN/mm, Air Voids 3.5 % dan film thickness 8 μm.Key word : Asphalt mixture Latasir B, and waste rubber tires, Marshall test
PERENCANAAN ULANG BALOK BETON BERTULANG PADA GEDUNG RUSUNAWA UMM DENGAN METODE STRUT AND TIE
Authors: Fitrianti Dona Dwi , Septiropa Zamzami , Rommel Erwin
Published: May 2017

Deep beam is the reinforced concrete structure, which has loads like normal beam, but has acomparatively high rate / width of a large, with clean span of Ln equal to or less than four times theoverall member height (h) or twice effectively depth beam (2d ) from the face of support withconcentrated loading. Strut and Tie Model (STM) is a method used to find the balance between loadand reaction forces in the concrete and steel.Redesign on Rusunawa beams using deep beam structure that consists of, beam 0.9 mx0,3mwith length 6.8 m that loaded of concentrated loading and deep beam 1.3 mx0, 4m by 4.2 meterslong that uniformly distributed loading. quality of concrete is used 25 Mpa and the quality of Steel350 MpaFrom the results of planning by using Strut and Tie Model (STM), obtained main flexurereinforcement of 6.8 meters is 4D19 for tensile bar and 5D19 for assembling bar. and Ø8- 160mmfor horizontal and vertical stirrups. As for the deep beam spans 4.2 meters, obtained flexurereinforcement is 5D20 for tensile and assembling bar and Ø8 - 220.2 mm for horizontal and verticalstirrups.Keywords: Deep beam, Strut and Tie method
STUDI EVALUASI DAN PERENCANAAN SISTEM JARINGAN DRAINASE PADA BAGIAN WILAYAH KOTA ( BWK II ) UNAAHA KABUPATEN KONAWE SULAWESI TENGGARA
Authors: Umar Irvan
Published: May 2017

City Area II ( BWK II ) Unaaha since 1982 became the capital of Kendari Residence anddeveloped into Konawe residence in 2004 as the shape of regional autonomy spirit and developmentin northeast Sulawesi.Drainage Sistem condition in Unaaha city could be said lack ability in supportingbanishment whether from household waste or rain debt as hydrology effect happened in the area. Itmade Unaaha faced serious matters caused by flood which happened in several regions, especiallywhen rainy season came. So, there needed evaluation of canal capacity and new drainage systemplanning.According to evaluation, there found that there were several canal which didn’t able to interceptflood debt in 2 years ( Q 2 years ), so that needed re-plan of canal plane. New drainage canalplanning also needed to reduce water slick when it rained. There also needed supporting buildings,water channels in drainage which able to minimize the slick area.Key word : Drainage, flood debt, normalization, planning evaluation
PENGEMBANGAN SISTEM JARINGAN DISTRIBUSI AIE BERSIH DI KECAMATAN TUREN.
Authors: Ali Moh. Abdullah
Published: May 2017

The population growth and district expansion needs supplying of clean water to fullfill thebasic requirements for the citizens, even from the quantity and quality. The distribution networksystem in that area using gravitation with heterogen pipe. The control to debite and pressure usedas parameter the operation of network service to the customer needs of clean water.Existing ( 2008 ) the population was 50237 people, with the growth average on 0,2percen each year. The needs of clean water at 23,8 lt/dt at the top of condition on the 60 percenservice level. From the analyst known that for the population at 2019 wich accounted by Geometricmethode was at 65,344 people. The clean water needs 106,4 lt/dt at the top of condition on 80percen service level.The plan for developing distribution network system, network simplication to minimizeof over network and to decrease the reducer cause of pipe curve at the existing network. Thenetwork pipe at Turen area needs increasing pipe on the existing condition 255 pipes with increasingto be 300 pipes. Node from the existing condition 251 node with increasing to be 287 node. Theresult of software WaterNet simulation is the dimension of network pipe for 2019. The dimensionof distribution pipe network before developing from the resouce to the customer are 250 mm, 200mm, 160 mm, 110 mm, 90 mm, 63 mm, and 40 mm. While the dimension of distribution pipenetwork after developing are 355 mm, 315 mm, 250 mm, 200 mm, 160 mm, 110 mm, 90 mm, 63mm, and 40 mm.Keyword : Network pipe system, Water needs, Developing
PEMBELAJARAN INTERAKTIF BERBASIS ICT (INFORMATION AND COMMUNICATION TECHNOLOGY) DALAM MATERI VERTEBRATA PADA SISWA MA MUHAMMADIYAH 1 MALANG
Authors: Afifatun Nisa Nurisma , Latifa Roimil , Krisno Budiyanto Moch. Agus
Published: May 2017

PEMBELAJARAN INTERAKTIF BERBASIS ICT (INFORMATION AND COMMUNICATION TECHNOLOGY) DALAM MATERI VERTEBRATA PADA SISWA MA MUHAMMADIYAH 1 MALANG   Nurisma Afifatun Nisa1, Roimil Latifa1, Moch. Agus Krisno Budiyanto1 1Pendidikan Biologi FKIP Universtias Muhammadiyah Malang, e-mail: biologi.umm@gmail.com   ABSTRAK The development of ICT in Indonesia increasing along with the time passed by. Hopefully little by little the teacher start to accustomed to used ICT based learning to adapt with the mushroom growth of time mowdays. Interactive learning media based on ICT hopefully be able to help students in comprehend the difficult materials which complicates to be mastered by the students especially in vertebrate material. In this interactive learing media development research at vertebrate material serve the purpose of learning media for student and teacher to facilitate teacher in deliver the material, also the researcher be able to know the usage of interactive learning media based on ICT in the effectiveness of student learning. This research codunsted at 10 March 2013 until 19 Octobeer 2013 in MA Muhammadiyah 1 Malang. The result of this development is produce interactive learning media product based on ICT (Information and Communication Technology) that have been made.which is had pass through testing process and revised based on suggestion and input from material expert and media expert also comment from the trial run student. Student learning activity getting off the ground from dependent class to independent class. The effectiveness of learning result and process in interactive learning media development based on ICT to increasing student achievement grade X student of  MA Muhammadiyah 1 Malang getting off the ground based the data that have been obtained.   Kata kunci: Vertebrate, Interactive Learning Media, ICT (Information and Communication Technology)
PENERAPAN PEMBELAJARAN KOOPERATIF DENGAN METODE PROBLEM SOLVING MENINGKATKAN HASIL BELAJAR IPA SMP
Authors: Ariska Fitari Diyah , Susetyarini Rr Eko , . Sukarsono
Published: May 2017

PENERAPAN PEMBELAJARAN KOOPERATIF DENGAN METODE PROBLEM SOLVING MENINGKATKAN HASIL BELAJAR IPA SMP   Diyah Ariska Fitari1, Rr Eko Susetyarini1, Sukarsono1 1Program Studi Pendidikan Biologi FKIP Universtias Muhammadiyah Malang, e-mail: biologi.umm@gmail.com   ABSTRAK   Penelitian ini bertujuan untuk mendeskripsikan bagaimana pelaksanaan model pembelajaran kooperatif dengan metode problem solving dapat meningkatkan hasil belajar siswa kelas VIII SMP Negeri 1 Suboh, serta  meningkatkan hasil belajar siswa kelas VIII SMP Negeri 1 Suboh dalam model pembelajaran kooperatif dengan metode problem solving. Hasil Penelitian Tindakan Kelas (PTK) yang dilaksanakan dengan menerapkankan Model Pembelajaran Kooperatif dengan Metode Problem Solving ini menunjukkan peningkatan hasil belajar siswa pada setiap siklusnya. Pada siklus I terdapat 21 siswa yang tuntas hasil belajarnya dan 9 siswa tidak tuntas hasil belajarnya (ketuntasan mencapai 70%). Sedangkan pada siklus 2 terjadi peningkatan pada hasil belajar siswa yang mengalami ketuntasan sebanyak 28 siswa dan 2 siswa yang tidak tuntas (ketuntasan mencapai 93%). Oleh karena itu dalam penelitian ini dapat disimpulkan bahwa penelitian tindakan kelas dengan menerapkan Model Pembelajaran Kooperatif dengan Metode Problem Solving telah berhasil dengan melihat kenaikan hasil belajar siswa kelas VIIIB di SMP Negeri 1 Suboh Kabupaten Situbondo.   Kata kunci: model pembelajaran kooperatif, metode problem solving, dan hasil belajar.
INDEKS PENULIS, JURNAL PENDIDIKAN BIOLOGI INDONESIA (JPBI) ISSN: 2442-3750 Volume 1, Nomor 1, Maret 2015
Authors: PENULIS INDEKS
Published: May 2017

INDEKS PENULIS     Abdulkadir Rahardjanto                                                                       109 Ainur Rofieq                                                                                         71 Atok Miftachul Hudha                                                                          49, 109 Citra Marina                                                                                          71 Darwis Husain                                                                                       1 Elly Purwanti                                                                                         78 Fega Rahmayani                                                                                    49 Feni Nur’aini                                                                                         36 Iin Hindun                                                                                             9, 49 Henia Wati                                                                                            109 Ilham Budi Setyawan                                                                            78 Lise Chamisijatin                                                                                   36 Miftakhul  Jannah                                                                                  88 Moch. Agus Krisno Budiyanto                                                             9, 18 Novita Adiqka Putri                                                                              29 Nurisma Afifatun Nisa’                                                                         18 Nurul Mahmudati                                                                                  1 Nurwidodo                                                                                            29, 36 Poncojari Wahyono                                                                               62 Qorry Aulya Rohmana                                                                          62 Roimil Latifa                                                                                         18 Rr Eko Susetyarini                                                                                88, 99 Samsun Hadi                                                                                         62 Sri Riani                                                                                                 9 Sri Wahyuni                                                                                           71 Sukarsono                                                                                              1, 99 Yuni Pantiwati                                                                                      29 Wahyu Prihanta                                                                                     78, 88