bluuebunny/crossref_metadata_2025 huggingface dataset:
Baseline Characteristics of the Vitamin D and Type 2 Diabetes (D2d) Study: A Contemporary Prediabetes Cohort That Will Inform Diabetes Prevention Efforts
Authors: LeBlanc Erin S. , Pratley Richard E. , Dawson-Hughes Bess , Staten Myrlene A. , Sheehan Patricia R. , Lewis Michael R. , Peters Anne , Kim Sun H. , Chatterjee Ranee , Aroda Vanita R. , Chadha Chhavi , Neff Lisa M. , Brodsky Irwin G. , Rosen Clifford , Desouza Cyrus V. , Foreyt John P. , Hsia Daniel S. , Johnson Karen C. , Raskin Philip , Kashyap Sangeeta R. , O’Neil Patrick , Phillips Lawrence S. , Rasouli Neda , Liao Emilia P. , Robbins David C. , Pittas Anastassios G. ,   D2d Research Group, LeBlanc Erin S. , Pratley Richard E. , Dawson-Hughes Bess , Staten Myrlene A. , Sheehan Patricia R. , Lewis Michael R. , Peters Anne , Kim Sun H. , Chatterjee Ranee , Aroda Vanita R. , Chadha Chhavi , Neff Lisa M. , Brodsky Irwin G. , Rosen Clifford , Desouza Cyrus V. , Foreyt John P. , Hsia Daniel S. , Johnson Karen C. , Raskin Philip , Kashyap Sangeeta R. , O’Neil Patrick , Phillips Lawrence S. , Rasouli Neda , Liao Emilia P. , Robbins David C. , Pittas Anastassios G.
Published: June 2018

OBJECTIVE

To describe baseline characteristics of the Vitamin D and Type 2 Diabetes (D2d) study, the first large U.S. diabetes prevention clinical trial to apply current American Diabetes Association (ADA) criteria for prediabetes.

RESEARCH DESIGN AND METHODS

This is a multicenter (n = 22 sites), randomized, double-blind, placebo-controlled, primary prevention clinical trial testing effects of oral daily 4,000 IU cholecalciferol (D3) compared with placebo on incident diabetes in U.S. adults at risk for diabetes. Eligible participants were at risk for diabetes, defined as not meeting criteria for diabetes but meeting at least two 2010 ADA glycemic criteria for prediabetes: fasting plasma glucose (FPG) 100–125 mg/dL, 2-h postload glucose (2hPG) after a 75-g oral glucose load 140–199 mg/dL, and/or a hemoglobin A1c (HbA1c) 5.7–6.4% (39–46 mmol/mol).

RESULTS

A total of 2,423 participants (45% of whom were women and 33% nonwhite) were randomized to cholecalciferol or placebo. Mean (SD) age was 60 (9.9) years and BMI 32.1 (4.5) kg/m2. Thirty-five percent met all three prediabetes criteria, 49% met the FPG/HbA1c criteria only, 9.5% met the 2hPG/FPG criteria only, and 6.3% met the 2hPG/HbA1c criteria only. Black participants had the highest mean HbA1c and lowest FPG concentration compared with white, Asian, and other races (P < 0.01); 2hPG concentration did not differ among racial groups. When compared with previous prediabetes cohorts, the D2d cohort had lower mean 2hPG concentration but similar HbA1c and FPG concentrations.

CONCLUSIONS

D2d will establish whether vitamin D supplementation lowers risk of diabetes and will inform about the natural history of prediabetes per contemporary ADA criteria.
Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp
Authors:   The RISE Consortium, Ehrmann David A. , Temple Karla A. , Rue Abby , Barengolts Elena , Mokhlesi Babak , Van Cauter Eve , Sam Susan , Miller M. Annette , Kahn Steven E. , Atkinson Karen M. , Palmer Jerry P. , Utzschneider Kristina M. , Gebremedhin Tsige , Kernan-Schloss Abigail , Kozedub Alexandra , Montgomery Brenda K. , Morse Emily J. , Mather Kieren J. , Garrett Tammy , Hannon Tamara S. , Lteif Amale , Patel Aniket , Chisholm Robin , Moore Karen , Pirics Vivian , Pratt Linda , Nadeau Kristen J. , Gross Susan , Zeitler Philip S. , Williams Jayne , Cree-Green Melanie , Garcia Reyes Yesenia , Vissat Krista , Arslanian Silva A. , Brown Kathleen , Guerra Nancy , Porter Kristin , Caprio Sonia , Savoye Mary , Pierpont Bridget , Buchanan Thomas A. , Xiang Anny H. , Trigo Enrique , Beale Elizabeth , Hendee Fadi N. , Katkhouda Namir , Nayak Krishan , Martinez Mayra , Montgomery Cortney , Wang Xinhui , Edelstein Sharon L. , Lachin John M. , Hogan Ashley N. , Marcovina Santica , Harting Jessica , Albers John , Hill Dave , Savage Peter J. , Leschek Ellen W.
Published: June 2018

OBJECTIVE

To compare insulin sensitivity (M/I) and β-cell responses in youth versus adults with impaired glucose tolerance (IGT) or drug-naïve, recently diagnosed type 2 diabetes.

RESEARCH DESIGN AND METHODS

In 66 youth (80.3% with IGT) and 355 adults (70.7% IGT), hyperglycemic clamps were used to measure 1) M/I, 2) acute (0–10 min [first phase]) C-peptide (ACPRg) and insulin (AIRg) responses to glucose, 3) steady-state C-peptide and insulin concentrations at plasma glucose of 11.1 mmol/L, and 4) arginine-stimulated maximum C-peptide (ACPRmax) and insulin (AIRmax) responses at plasma glucose >25 mmol/L. The fasting C-peptide–to–insulin ratio was used as an estimate of insulin clearance.

RESULTS

Insulin sensitivity was 46% lower in youth compared with adults (P < 0.001), and youth had greater acute and steady-state C-peptide (2.3- and 1.3-fold, respectively; each P < 0.001) and insulin responses to glucose (AIRg 3.0-fold and steady state 2.2-fold; each P < 0.001). Arginine-stimulated C-peptide and insulin responses were also greater in youth (1.6- and 1.7-fold, respectively; each P < 0.001). After adjustment for insulin sensitivity, all β-cell responses remained significantly greater in youth. Insulin clearance was reduced in youth (P < 0.001). Participants with diabetes had greater insulin sensitivity (P = 0.026), with lesser C-peptide and insulin responses than those with IGT (all P < 0.001) but similar insulin clearance (P = 0.109).

CONCLUSIONS

In people with IGT or recently diagnosed diabetes, youth have lower insulin sensitivity, hyperresponsive β-cells, and reduced insulin clearance compared with adults. Whether these age-related differences contribute to declining β-cell function and/or impact responses to glucose-lowering interventions remains to be determined.
Gender bias in student evaluation of teaching among undergraduate business students
Authors: Ólafsdóttir Katrín
Published: June 2018

While half of undergraduate students in business are women, only one in five full professors in business in the US are female. According to the pipeline theory, this discrepancy should correct itself through time and more women join the ranks of full professors. However, the pipeline seems to leak, as the adjustment is slow. Student evaluations of teaching (SET) is one of the measures used to evaluate faculty. If there is a gender bias in student evaluations, where female faculty is valued less than male faculty, this could contribute to the leaky pipeline by reducing women’s promotion possibilities. Looking at student evaluations among undergraduate business students at an Icelandic university in 127 courses from 2010 to 2015, I estimate the difference between SET for male and female faculty, using random-effects ordered logit regressions. I find that female faculty receive lower evaluations than male faculty in a simple model. In a model linking each of the covariates with gender I find an even greater gender bias for full-time faculty, while female part-time instructors receive higher SET than their male counterparts.
Skipulag fyrirtækja á Íslandi fyrir og eftir hrun
Authors: Steinþórsson Runólfur Smári , Þórarinsdóttir Anna Marín , Svansson Einar
Published: June 2018

Viðfangsefni greinarinnar er þróun á skipulagi fyrirtækja á Íslandi fyrir og eftir fjármálahrunið árið 2008. Byggt er á rannsóknum í verkefninu Innform á Íslandi, annars vegar frá 2004 til 2007 og hins vegar frá 2010 til 2014. Einnig er gerður samanburður á milli fimm rannsókna sem gerðar hafa verið um skipulag fyrirtækja á Íslandi á árunum fyrir og eftir hrun. Markmið greinarinnar er að lýsa megineinkennum á stjórnskipulagi íslenskra fyrirtækja og gera grein fyrir þróun á skipulagi þeirra. Jafnframt er markmiðið að kanna hvort sjá megi breytingar á skipulagi íslenskra fyrirtækja eftir efnahagshrunið 2008 á ýmsum stjórnunarþáttum sem tengjast skipulagi. Helstu niðurstöður gefa vísbendingar um að stjórnskipulag íslenskra fyrirtækja hafi tekið nokkrum breytingum og að áhersla á innri ferla og skilvirkni sé meiri. Umboðsveiting hefur aukist og sú breyting tengist aukningu á fléttu- og verkefnaskipulagi. Rannsóknirnar sýna að flest stór íslensk fyrirtæki notast bæði við afurðaskipulag og starfaskipulag, sem gefur vísbendingu um blandað skipulag. Starfaskipulag er hins vegar ríkjandi skipulagsform þegar litið er til bæði smærri og stærri fyrirtækja. Það virðist hafa verið millibilsástand hjá fyrirtækjum á Íslandi varðandi stjórnskipulag fyrst eftir hrun þar sem áhersla æðstu stjórnenda á formlegt skipulag minnkaði tímabundið.
SEASONAL DYNAMICS OF FATTY ACIDS COMPOSITION IN TISSUE OF RAINBOW TROUT PARASALMO MYKISS (WALBAUM, 1792), CULTIVATED ON VARIOUS DIETS
Authors: Vasilieva Olga Borisovna , Nazarova Marina Aleksandrovna , Nemova Nina Nikolaevna
Published: June 2018

A comparative study of the composition of fatty acids in muscles, liver and internal fat in rainbow trout Parasalmo mykiss (Walbaum, 1792) grown on various diets in the period from April to July was effected. Differences in content of dietary fatty acids in diet 1 and diet 2 were found. A significantly lower level of long-chain polyunsaturated fatty acids (including physiologically significant eicosapentaenoic 20: 5(n-3) and docosapentaenoic 22: 6(n-3) acids) was detected in diet № 2, compared to diet № 1. As a result, deficiency of dietary eicosapentaenoic and docosapentaenoic acids leads to a slow rate of fishes growth. A significant influence of the trophic factor on the distribution of fatty acids in muscles and internal fat of fish is shown, because lipids in rainbow trout accumulate in these tissues. The degree of accumulation of different dietary fatty acids in muscles and internal fat of trout was depended on fatty acids that prevailed in the diet on which the rainbow trout was grown. A high degree of influence of the trophic factor on the level of polyunsaturated fatty acids of families n-9 and n-4 was found, the content of which in trout tissues was about 1%. Composition of fatty acids in trout liver, as the most metabolically active organ, is less conditioned by the influence of the factors studied. The degree of assimilation of docosahexaenoic 22: 6 (n-3) acid in rainbow trout probably depended on the level of eicosapentaenoic 20: 5 (n-3) acid in the diet. It has been stated that changing the level of fatty acids in muscles and internal fat of trout during seasonal changes is associated with an increase in the frequency of feeding of fishes in the summer.
BREAM FECUNDITY (ABRAMIS BRAMA LINNAEUS, 1758) IN THE VOLGA DELTA
Authors: Ivanov Vladimir Prokofievich , Levashina Natalia Vadimovna
Published: June 2018

Negative processes in the North Caspian related to low water in 2006, 2008-2012, 2014 and 2015 have resulted in drastic decrease of abundance of the most numerous species - bream Abramis brama (Linnaeus,1758). Bream remains the main mass species of the Volga-Caspian region, despite changes in qualitative structure of the population, reducing age, size and weight of species in commercial catches. The article presents research results of bream Abramis brama fecundity and changeability depending on the environment. Deterioration of habitat conditions of bream population adversely affected all biological indicators of bream; in particular, absolute fecundity of females has decreased. There has been established some positive correlation dependence of individual absolute fecundity with length, weight and age of a species. The work presents correlation parameters, equations of regression. There has been observed a decrease in relative fecundity of bream Abramis brama , which is a main indicator of intensive reproduction of the population in changing environment. The article gives data on dramatic reduction of bream maturation rate. The research results provide practical value in solving problems of fish stocks regulation, abundance recovery and increased catches of bream in the Volga-Caspian region.
La desnudez en el arte argentino. Mujeres artistas y desnudos en las décadas de 1920 y 1930
Authors: Gluzman Georgina Gabriela
Published: June 2018

Este artículo analiza un conjunto de pinturas realizado por artistas argentinas, en un esfuerzo por volver visibles formas radicales de mostrar el cuerpo de la mujer en el arte argentino de la época. Las pintoras compartieron las instalaciones ofrecidas por el Salón Nacional y, por lo tanto, trataron de ser parte de la escena del arte oficial. Sin embargo, crearon imágenes que cuestionaron el derecho masculino de mirar y que ofrecieron un fuerte contraste con las obras de artistas varones. Junto con las figuras en la tradición de la Escuela de París, que inundaron las exposiciones anuales, esta olvidada corriente subterránea femenina ofrece una oportunidad para reflexionar sobre los prejuicios que han dado forma a la historia oficial del arte en la Argentina
A NOVEL APPLICATION OF CHAOTIC PROPERTIES IN WATER TREATMENT PLANT
Authors: Natarajan Sridhar , Kumaar S. Senthil
Published: June 2018

This paper aims at presenting a new optimization proposal to enhance the flocculation process in Water Treatment (WT) plant using a better flash mixing, located at KELAVERAPALLY, in Krishnagiri district, Tamil Nadu, India. Further, Sludge removal is done efficiently which decreases the water wastage as well as improvement in output water quality. Though WT plants are already equipped with systematic and sequential physicochemical processes, still they need to be optimized to obtain a better treated drinking water to maintain the quality standards as prescribed by World Health Organization. Chaotic behavior in chemical systems has been used to optimize the performance of WT plant. Measurement systems implemented in WT plant yield several chaotic based measurement parameters which are used to control the system operations to maintain the target water quality.Â  This intelligible data extraction through the proposed measurement Â systems in a short span of time improves the plant performance without adding any costly systems except few changes in the existing plant setup. Â Chaotic behavior is ensured through Lyapunov Exponents and Kolmogorov-Sinai Entropies. Both, water quality improvement and water wastage reduction is achieved simultaneously in the proposed work when a dosage prediction is done using Feed Forward Neural Networks. The treatment plant investigated has a maximum capacity of 14 MLD (Million litres per day) using two parallel streams with 7 MLD each
Creating Legal Certainty in Sharia Banking Law Systems through the Embodiment of Sharia Compliance Principle
Authors: Nasikhin Muh. ,   Muhaimin, Haq L. M. Hayyanul , Asikin Zainal
Published: June 2018

This work is aimed at creating legal certainty sharia compliance arrangements in sharia banking law systems. This idea is highly required to improve the credibility of the sharia-based business activities. Certainly, this study is relevant to solve some normative problems in regulating and managing of the sharia banking activities, particularly regarding sharia compliance. In detail those normative problems can be seen from the inconsistence and ambiguous norms, conflicted norms and legal vacuum in regulating sharia compliance principle. To visualize and elaborate the above issues, these works apply normative legal research, where all data are collected through intensive and extensive literature review. Those data will be analysed by philosophical, statute and conceptual approach. The core issues that will be elaborated in this work are: (i) formulating Islamic values to the some relevant sharia banking law principles; (ii) some normative problems construction of sharia compliance principles in sharia banking law systems; (iii) reconstructing of regulating sharia compliance principles to creating legal certainty. At the end, this work will offer appropriate model in coherence those normative problems in order to creating legal certainty in managing and regulating sharia banking law.
The Importance of Human Resources in Corporate Governance
Authors: Athmen Bouziane , Samia Belhadef
Published: June 2018

The purpose of this research is to clarify the status of human resources in terms of corporate governance through chart analyses. These analyses are based on theoretical principles that clarify the relationship between human resources and corporate governance, and they are divided based on two perspectives. The first one is the corporate governance perspective, and the second is that of the human resources, whereas the administrative board is considered as a common point between them. Human resources is one the most important points that must be addressed by corporate governance. The literature review of this study includes the theories and models of corporate governance, such as the Agency Theory, and the Theory of Stakeholders, and Shareholders Model. As for the literary sources for the study of human resources, they include articles specialized in the study of corporate governance and human resources to analyze the relationship between them based on a series of methodological steps including the literature review and the collection of relevant data from primary and secondary sources.
Estudio del consumo de la carne de cerdo en la zona metropolitana del Valle de México
Authors: Cortés Tinoco Guillermo Felipe , Mora Flores José Saturnino , García Mata Roberto , Ramírez Valverde Gustavo
Published: June 2018

El objetivo del trabajo fue realizar una caracterización del consumidor de carne de cerdo en la Zona Metropolitana del Valle de México, para conocer el tipo de productos que demanda de acuerdo con su nivel de ingresos, y los servicios integrados a estos. La metodología empleada fue el de tablas personalizadas para segmentar las variables cuantitativas y categóricas de carácter económico-social; se realizaron pruebas de asociación de variables mediante la distribución X2. Se levantó una encuesta semiestructurada aplicada a 440 individuos. Entre los principales resultados se encontró que el ingreso y consumo bajos están correlacionados positivamente con los tipos de cortes de carne, frescura del producto, lugar de venta y cantidad de cortes adquiridos. La variable sin relación significativa con el consumo e ingreso fue el número de servicios agregados a la carne. Se concluye que los consumidores con ingresos bajos y medios demandan cortes populares (chuleta, bistec, espinazo, maciza, pierna y otras piezas). Consumen principalmente carne fresca (caliente) y la adquieren en mercados públicos y carnicerías de barrio.
The Comparison of Tnf α (Tumor Necrosis Factor α) Serum Levels Between Cytotoxin - Associated Gene A (Caga) Positive and Negative in Patients with Gastritis Helicobacter pylori
Authors: Karo Fitri Armanti , Dairi Leonardo Basa , Siregar Gontar Alamsyah
Published: June 2018

Background: Helicobacter pylori (H. pylori) infection is the common cause of chronic gastritis in the world that is around 80% in addition to other causes such as autoimmune diseases, drugs, idiopathic and others. The pathogenesis of H. pylori associated with virulence factors consisting of cytotoxin - associated gene A (CagA) and vacuolating cytotoxin A (Vaca). In the case of gastritis occurred acute and chronic inflammatory responses and activation cytokines that cause inflammation of mucous which TNF-α levels increased in patients gatritis H. pylori. Levels of serum TNF-α was found higher in patients infected with H. pylori with CagA positive. The purpose of this study is to investigate the comparison between TNF-α serum level in H. pylori gastritis patients with Cag A (+) and CagA (-).Method: The study was conducted with a cross-sectional design in 30 patients with dyspepsia, using PADYQ score. We performed gastroscopy, biopsy, and CLO test to prove the existence of H. pylori. Furthermore, we used PCR to assess CagA (+) and CagA (-), and ELISA method to measure TNF-α serum level.Results: From 30 subjects, 18 men (60%), 12 women (40%), and the mean age was 53.5 years, the majority of the ethnic was Bataknese  (53.3%), patients with H. pylori gastritis with CagA (+) were 21 (70%) and patients with H. pylori gastritis with CagA (-) were 9 (30%). We found the mean serum levels of TNF-α was higher (3.48) in H. pylori gastritis with CagA (+) than the CagA (-) (1.29) with p value was 0.001.Conclusion: We found increased serum levels of TNF-α in patients with CagA (+) compared to Cag A (-) H. pylori gastritis.
Effects of Curcumin Against Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor Metalloproteinase-2 (TIMP-2) Serum Level on Rat Model of Liver Fibrosis Resolution Process
Authors: Supriono Supriono , Pratomo Bogi , Kriestian Muhammad
Published: June 2018

Background: Liver fibrosis is an effect from continuous fibrogenesis and fibrolysis process. During fibrogenesis, MMP-2 and TIMP-2 that produced by hepatic stellate cell (HSC) have a role to regulate extracellular matrix (ECM) homeostastic. Otherwise, curcumin inhibits both MMP-2 and TIMP-2 expression and enhances HSC apoptosis, thus inhibit fibrogenesis. Role of curcumin, MMP-2, and TIMP-2 in a fibrolysis process has not been widely studied. This study aimed to determine the correlation between curcumin administration and the decline of MMP-2 and TIMP-2 on rat model of liver fibrosis.Method: This is an experimental study done in male Wistar rats. There are 8 groups consist of 4 rats each. Both control and intervention group were exposed to CCl4 1 cc/kgBW intraperitoneally 2 times per week for 9 consecutive weeks to form F3 fibrosis. Negative control group was injected with normal saline. After CCl4 injection, control group was given curcumin solvent as placebo while intervention groups were given curcumin 200 mg/kgBW for 2, 5, and 9 weeks. Statistical analysis then conducted in the end of study. Results: MMP-2 and TIMP-2 were remarkably increased in positive control group, but found decreased in control group 5 and 9. There are remarkable decrease of MMP-2 and TIMP-2 serum level in intervention group 2, 5, and 9, but MMP-2 and TIMP-2 level was significantly lower in intervention group 2 compared to the control group.Conclusion: MMP-2 and TIMP-2 serum level were decreased after giving of curcumin for 2 weeks. The duration of curcumin administration correlated with decrease of TIMP-2 serum level but not correlated with MMP-2 serum level in rat model of liver fibrosis.
Advanced Gastric Cancer in a Young Male Patient
Authors: Febyan Febyan , Martamala Ruswhandi , Nurliana Diany , Salmi Salmi
Published: June 2018

Gastric cancer remains the second most common GI cancer in the world, and is usually found in men, especially those over 50 years of age. Gastric cancer is a multifactorial disease resulting from the interactionbetween genetic and environmental factors at the stomach mucosa level. The diagnosis is made by endoscopic biopsy. The high frequency of late diagnosis or advanced stages accounts for the overall poor prognosis for this tumor. Surgery is the most frequently employed modality for both cure and palliation. However, most patients present with advanced disease that is incurable. We reported a rare case of young male patient aged 24 years old with advanced gastric adenocarcinoma. The main clinical features were epigastric pain, vomiting, melena and weight loss. An abdominal mass was palpable on physical examination. Endoscopy showed a giant tumor mass causing gastric outlet obstruction, that appear edematous, there were hemorrhagic lesions. The histopathologic examination revealed poorly differentiated adenocarcinoma. Palliative resection could not be performed because the tumor tightly adhered to adjacent structures. Jejunostomy or nasojejunostomy tube were performed to allow enteral nutrition. Best supportive care is very important to improve the quality of life.
Unusual Case of Massive Obscure Gastrointestinal Bleeding: Ectopic Varices in Jejunum Caused by Arteriovenous Malformation
Authors: Maulahela Hasan , Renaldi Kaka , Syam Ari Fahrial
Published: June 2018

Small bowel ectopic varices is a rare etiology for obscure gastrointestinal bleeding. Ectopic varices in the absence of portal hypertension can be caused by congenital or familial conditions (e.g. malformation of vessel). Bleeding caused by ectopic varices can be massive and life threatening. Single Balloon Enteroscopy (SBE) is one of diagnostic modalities for obscure gastrointestinal bleeding. We report one case of obscure overt gastrointestinal bleeding with sub-acute onset. Previous esophagogastroduodenoscopy and colonoscopy cannot found the source of bleeding. On the enteroscopy we found varices at proximal jejunum with active bleeding during procedure. We applied hemostatic powder to stop the bleeding and proceed to surgery. Surgery was performed by enteroscopy guide. The jejunum section with varices was resected and the pathology confirmed the malformation of arteriovenous. Currently there is no available guideline or randomized study for the treatment of ectopic varices. Treatment options include ligation, sclerotherapy, surgery and interventional radiology. In this patient we choose surgery because of massive gastrointestinal bleeding.
ENDOSCOPIC PHOTODYNAMIC THERAPY OF A PATIENT WITH LUNG CANCER METASTASIS IN BIFURCATION LYMPH NODES (CLINICAL OBSERVATION)
Authors: Legostaev V. M. , Babenkov O. Yu. , Balitskiy G. V.
Published: June 2018

Abstract

This clinical case demonstrates the feasibility of photodynamic therapy (PDT) as a method of choosing the treatment of recurrent lung cancer in inoperable patients with ineffective chemoradiotherapy. An operation was performed on the patient with a diagnosis of pT4N0M0 central cancer of the lower lobe of the right lung after 2 courses of neoadjuvant chemotherapy in October 2015: an expanded combined lower bilobectomy of the right lung, with resection of the pericardium and left atrium. Then 4 courses of adjuvant chemotherapy (cisplatin + vinorelbine) and a course of radiotherapy on the mediastinum area up to a total dose of 45 Gy were carried out. After 2 months, a metastatic lesion of bifurcation lymph nodes with invasion of the mucosa of the tracheal bifurcation, involving the distal trachea, proximal right and left main bronchi was detected. The result of histological analysis: G2 squamous cell carcinoma without keratinization. From Dec 2016 to Jun 2017, the patient underwent 5 courses of PDT, as a result of which a significant cytoreductive effect and stabilization of the process were achieved. The continuation of the PDT treatment is planned.
Research on The Application of Foresight in The Development of Strategies and Policies for Management of Natural Resources and Environment in Vietnam
Authors: Hoàng Thanh Hương
Published: June 2018

Vietnam is facing serious environmental and resource issues that directly affect the community. Therefore, in the current context, management must have immediate and long-term orientations in the formulation of strategies and policies, so that, we need to do well the forecasting work. In contrast to the closed approach of traditional forecasting approach, the foresight approach is seen as a way of communicating, exchanging and negotiating among different parts of society, thereby discovering scientific, economic, cultural and social value contributes to the general society in the future, while integrating in the process of forecasting issues to be discussed, evaluated, analyzed and proposed. The Vietnamese policy has not now achieved the desired effect. Thus, foresight can be considered as a new approach to support forecasting in the development of the sector strategy for natural resources and environment.

The paper focuses on some of the world's foresight approaches and attempts to answer two questions: (i) How does this approach be used in the development of the strategy? (ii) Applicability in forecasting strategies and policy formulation in Vietnam. Answers to these two questions will provide recommendations so that be able to apply this approach for the development of the strategy and policy on natural resources and the environment in Vietnam.
Aristolochia chlamydophylla (Aristolochiaceae), a new record for the flora of Vietnam
Authors: Nguyen Thanh Trung , Oanh Pham Thi , Truong Do Van
Published: June 2018

Abstract: Aristolochia chlamydophylla C.Y. Wu ex S.M. Hwang, a medicinal plant and main distribution from northern Thailand and south-eastern China, is newly recorded for the flora of Vietnam. This species was misidentified to A. kaempferi in Vietnamese herbaria. An extent description, illustrations and taxonomic notes of Aristolochia chlamydophylla are also provided.
Some Theoretical, Legal and Practical Issues on Human Rights of Aliens
Authors: Vũ Công Giao , Nguyễn Đình Đức
Published: June 2018

This paper tries to analize concept “alien” and “rights of aliens”, to explain the differences between “rights of citizen” and “rights of aliens”, the history of formation, development as well as content of rights of aliens in international law and Vietnam law. The authors argue that Vietnam's legislation has made strides in protecting the rights of aliens in comparision of the standards of international human rights law since Vietnamese government published the Constitution 2013, however, there are still gap between the rights of foreigners and citizens which have been not really improved in the context of globalization.
The Protection of Employee According to Taiwan Labour Standards Act
Authors: Lin Geng-schenq
Published: June 2018

The Taiwan Labor Standards Act (LSA), which was established in 30, July 1984, is the most important law that protects labors in Taiwan. And it was only after the LSA was passed that the systematic researches on labour law begin. The LSA is a relative young field and many conceptions were uncertain, so by its implementations we inevitably have to face many difficulties. To this the Judiciary plays the decisive role. But as it is the common practice the judge frequently cites the scholars’ opinions to support the decision. In this article the author will explain how the judiciary cooperating with the scholars to give better answers, especially to protect the employee, through defining ‘employee’, ‘employer’, to the problems concerning the wages, the working hours and the dismissals. Overall, we agree with a famous German scholar Gallmmilscheg to say “Richterrecht bleibt unserer schicksal” (“Judiciary remains our destiny”) and the scholars will also make their contributions to this.
Reforming the power control mechanism at local level in Vietnam: approaching from the perspective of decentralization
Authors: Đặng Minh Tuấn , Hoàng Thị Ái Quỳnh
Published: June 2018

By analyzing the theory of local power control from the perspective of decentralization, this article points out the inadequacies of the Vietnamese local power control mechanism which has been influenced by the centralization principle. The article concludes that Vietnam has to enhance the decentralization in order to build a more effective local power control mechanism. However, the decentralization also leads difficulties and challenges for the control of local power. Therefore, it is necessary to establish solutions for the implementation of this mechanism.
Solar Electrochemical Thermal Process (STEP) Ammonia: Optimization of the Electrolysis Conditions
Authors: Li Fang-Fang , Singhal Richa , Ren Jiawen , Johnson Marcus , Lefler Matthew , Licht Stuart
Published: June 2018

In the solar thermal electrochemical process (STEP), sunlight is split into visible (for photovoltaic electricity) and thermal (unused, sub-bandgap) radiation using the full solar spectrum to efficiently drive high temperature electrolyzes. Electrolysis conditions for STEP ammonia are investigated. A mixed molten carbonate/hydroxide electrolyte with iron oxide catalyzes ammonia formation from water (steam) and air (nitrogen) via an iron intermediate. The higher temperature required for effective iron formation needs to be balanced by the lower temperature for effective hydration of the electrolyte. STEP ammonia is illustrated at a nickel anode and steel cathode at 650 °C in Li1.6Ba0.3Ca0.1CO3 with 6m LiOH and 1.5m Fe2O3.
JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neurons
Authors: Roessler Reinhard , Goldmann Johanna , Shivalila Chikdu , Jaenisch Rudolf
Published: June 2018

Phelan–McDermid syndrome (also known as 22q13.3 deletion syndrome) is a syndromic form of autism spectrum disorder and currently thought to be caused by heterozygous loss of SHANK3. However, patients most frequently present with large chromosomal deletions affecting several additional genes. We used human pluripotent stem cell technology and genome editing to further dissect molecular and cellular mechanisms. We found that loss of JIP2 (MAPK8IP2) may contribute to a distinct neurodevelopmental phenotype in neural progenitor cells (NPCs) affecting neuronal maturation. This is most likely due to a simultaneous down-regulation of c-Jun N-terminal kinase (JNK) proteins, leading to impaired generation of mature neurons. Furthermore, semaphorin signaling appears to be impaired in patient NPCs and neurons. Pharmacological activation of neuropilin receptor 1 (NRP1) rescued impaired semaphorin pathway activity and JNK expression in patient neurons. Our results suggest a novel disease-specific mechanism involving the JIP/JNK complex and identify NRP1 as a potential new therapeutic target.
THE INFLUENCE OF TOP-DOWN STRATEGY (TDS) ON STUDENTS’ READING COMPREHENSION
Authors: Prasetyo Dwi Darsa , Syam Ummi Khaerati , Saiful Saiful , Sangkala Ismail
Published: June 2018

This research aimed to find out the influence of Top-Down Strategy (TDS) on students reading comprehension that focus on level of literal and interpretative of comprehension. The researcher applied pre-experimental method with one group pre-test and post-test. The sample of this research was class XI MIA 2 of SMA Negeri 10 GOWA which consisted of 30 students. The sample was taken by using purposive sampling method. The result of the research were the mean score of pretest in Literal (main Idea) score of pretest was 58.6 and post-test was 86.56. In sequence of detail the score of pretest was 56.4 and post-test was 92.6 with t-test value Literal is greater than t-table (13.26 > 2.45). Mean score of intrepretative in pretest was 63.63 and post-test was 82 with the t-test value is greater that t-table (8.34 >2.45). The result of calculating t-test of the indicators in the students’-test (Literal and Interpretative) was greater than t-table 21.60 > 2.45. it means that there was significance different between before and after giving the treatment. Based on explanation above we concluded that using Top-Down Strategy is influence and improve students reading comprehension especially in literal and interpretative levels.
Fungsi dan Peran Api dalam Seni dan Kehidupan Masyarakat Bali
Authors: Sudibya I Gusti Ngurah , Sukerta Pande Made , Kusumo Sardono Waluyo , Supriyanto Eko
Published: June 2018

ABSTRACTFire is made up of three elements, such as heat, combustible materials and oxygen. A fire has heat and light. Fire is used in real life in various human life from cooking, to marriage and to burning dead bodies. Fire is available in space, on earth, and in oneself. Symbolically the fire is employed as a symbol of spirit, a sanctification, a destruction, enlightenment, heating temperatures, fire of romance, and fire of revenge. Overheated is possible when one ignores norms, ethics, and rules. Library studies, interviews, observations, and experiments are the methods used in this compilation. Fire both as symbol and text, functioned according to the capacity/role of each, both in and outside themselves, the use of it must be controlled for the harmony of the macrocosms and microcosms, when is the right time is to use small, medium and large fire, because all of them is important.Keywords: function, fire, symbol, harmonic.ABSTRAKApi terbentuk dari tiga elemen yakni, panas, bahan mudah terbakar dan oksigen. Api memiliki panas dan cahaya. Api digunakan dalam kehidupan manusia dari memasak, penerangan, perkawinan sampai pembakaran jenazah. Api terletak di angkasa, di bumi, dalam diri. Api dijadikan simbol semangat, penyucian, peleburan, pencerahan, api asmara, api dendam. Terjadi over heated/panas berlebih yang tidak lagi mengindahkan norma, etika, aturan. Studi kepustakaan, wawancara, observasi, dan percobaan merupakan metode yang digunakan dalam penyusunan ini. Seyogyanya api baik sebagai simbol maupun teks, difungsikan sesuai kapasitas/perannya masing-masing, baik dalam diri maupun diluar diri, semua itu harus dikendalikan penggunaannya, agar keharmonisan bhuana alit dan bhuana agung dapat terwujud, kapan menggunakan api kecil, sedang maupun besar, karena semuanya penting.Kata kunci: fungsi, api, simbol, harmonis.
Evaluasi Pembangunan Sistem Visualisasi Data (Studi Kasus: Pengelolaan Data pada Kementerian Dalam Negeri Indonesia)
Authors: Abyadl Muhammad Fikry , Sumarno - , Indrianawati -
Published: June 2018

ABSTRAKPembangunan sistem visualisasi data (vista) Kemendagri merupakan langkah awalpengolahan data dan informasi Kemendagri oleh Pusdatinkomtel untuk menyederhanakan, mempermudah, mempercepat, memanipulasi, serta mengolah data dan informasi menjadi berbagai variasi penyajian data. Kebutuhan penyajian data dan informasi pada sistem vista disesuaikan dengan tugas pokok dan fungsi unit kerja di lingkungan Kemendagri. Tujuan penelitian ini adalah untuk mengevaluasi pembangunan sistem vista Kemendagri terkait data, metode, dan implementasi visualisasi data. Metode penelitian yang digunakan adalah metode top-­down, yaitu metode analisis kebutuhan data yang diturunkan berdasarkan tupoksi yang telah terbentuk di instansi tersebut. Hasil identifikasi data berdasarkan tupoksi Kemendagri selanjutnya dibandingkan dengan hasil identifikasi sistem vista Kemendagri sehingga dapat dilakukan analisis kesesuaian data. Dari hasil analisis tersebut, dapat diketahui bahwa sistem vista Kemendagri baru memenuhi 71,11% dari kebutuhan penyajian data dan informasi di lingkungan Kemendagri. Hal tersebut dikarenakan setiap kategori pada sistem vista masih terdapat kekosongan data sehingga belum memenuhi keseluruhan kebutuhan penyajian data.Kata kunci: visualisasi data, sistem visualisasi data, kementerian dalam negeriABSTRACTDevelopment of the Ministry of Home Affair’s data visualization system by Pusdatinkomtel is a first step in processing the Ministry of Home Affair’s data and information. The development aims to simplify, accelerate, facilitate, manipulate and process data and information into various data visualizations. Data and information visualization necessity develops in agreement with basic task and function of work unit in the Ministry of Home Affair’s. This study aims to evaluate development of the Ministry of Home Affair’s data visualization system related to the data, method, and implementation of data visualization. The research method in this study uses a top-­down method. The method analyses data needs based on the basic task and function of work unit in the Ministry of Home Affairs. Furthermore, data suitability analysis is done by comparing result of data identification based on the basic task and function of Ministry of Home Affair’s with data visualization system. The analysis result shows the Ministry of Home Affair’s data visualization system only fulfilling 71.11% from the data and information visualization necessity in the Ministry of Home Affair’s. This is because each category in data visualization system still has data gaps so it has not met the overall needs of data visualization.Keywords: data visualization, data visualization system, ministry of home affairs
Analisis Asas dan Tujuan dari Undang-Undang Kelautan, serta Peran Keilmuan Geodesi dan Geomatika dalam Implementasinya di Indonesia
Authors: Nugroho Agung P , Djunarsjah Eka , Windupranata Wiwin
Published: June 2018

ABSTRAKWilayah dan potensi kelautan yang besar di Negara Kesatuan Republik Indonesia (NKRI) memerlukan pengelolaan yang sesuai agar dapat terjaga dan termanfaatkan dengan baik. Penyusunan dan pengesahan undang-undang nomor 32 tahun 2014 tentang kelautan adalah suatu bentuk usaha yang dilakukan negara dalam menata dan mengatur ruang lautnya secara terpadu. Undang-undang kelautan di dalamnya mempunyai sebelas asas dan delapan tujuan. Asas dan tujuan tersebut berisi mimpi-mimpi besar di bidang kelautan Indonesia dan harapannya dapat dicapai melalui undangundang ini. Akan tetapi kenyataanya masih banyak pekerjaan yang harus dilakukan untuk mengimplementasikannya sehingga mencapai kondisi ideal yang diharapkan. Penelitian ini bertujuan mengetahui sejauh mana undang-undang dapat diimplementasikan melalui uji prasyarat hukum undang-undang. Hasilnya undang-undang kelautan memenuhi syarat sah dan absah, sehingga dapat diimplementasikan dari aspek muatan hukum tersebut. Sedangkan, hasil analisis SWOT dan semantik bahasa menunjukkan bahwa implementasi dari undang-undang kelautan masih jauh dari harapan. Harapan kedepannya dengan dibuatnya aturan-aturan pendukung dan diperbaikinya kinerja pemerintahan, maka implementasinya akan berjalan lebih baik. Peranan bidang geodesi dan geomatika dalam bidang kelautan sudah sampai dalam tahapan membantu berbagai permasalahan di bidang kelautan.Kata kunci: undang-undang, kelautan, asas, tujuan, implementasiABSTRACTLarge marine regions and potential in the Republic of Indonesia require appropriate management and maintainance. Drafting and legitimating of maritme law no. 32 in 2014 are government effort in maintining and organizing of Indonesia sea n integrated manner. Maritime law has eleven principles and eight objectives contained within. The principles and objectives contain big dreams for Indonesian marine. These dreams hope can be achieved with the existence of this law. But in fact is still much work to be done in implementing such a big dream to reach the ideal situation. This research aims to determine in which extent legislation can be implemented and carried out to test the legal prerequisite legislation, and the result is marine legislation qualified from legitimate and legal test so that it can be implemented from the aspect of the legal aspect. While the SWOT and semantic analysis can be seen that the implementation of marine legislation is still far from expectations, expected in the future with the establishment of rules from the and improved performance of the government, the implementation will be better. For the geodesy and geomatics roles are already in the level helpin in the problems of marine field.Keywords: law, principle, objective, implementation
Studi Awal Desain Hull USV (Unmanned Surface Vehicle) untuk Pengukuran Batimetri di Perairan Tenang
Authors: Azmar Zulfikar Banu , Perbani NMR Ratih Cahya
Published: June 2018

ABSTRAKUSV batimetri adalah wahana apung tanpa awak berdimensi kecil dan mudah dibawa untuk pengukuran batimetri. Penelitian ini bertujuan untuk mendesain bentuk hull USV yang stabil untuk keperluan survei batimetri di perairan tenang. Bentuk hull yang didesain berupa monohull yang dioperasikan di perairan tawar, hanya mempertimbangkan kestabilan statik vertikal untuk gerakan heave (yang disebabkan oleh bobot total USV) dan roll sudut kecil tanpa pengaruh angin dan arus. Hull USV didesain dengan panjang 1,64 meter; lebar 0,52 meter; dan tinggi total 0,26 meter di mana dua pertiga hull bagian bawah buritan berbentuk U dan sepertiga hull bagian bawah haluan berbentuk V. Draft rencana 0,08 m; 0,12 m; 0,16 m memiliki kestabilan statik vertikal yang baik dengan koefisien blok berkisar 0,68 - 0,71 sehingga dikategorikan sebagai kapal yang didesain bukan untuk kapal cepat. Bobot USV beserta muatan direkomendasikan antara 36 - 83 kg. Dari dimensi, bobot, dan koefisien blok yang cukup besar hull yang didesain dapat dikategorikan sebagai wahana apung tanpa awak berkecepatan rendah sehingga cocok untuk keperluan survei batimetri.Kata kunci: USV batimetri, heave, roll sudut kecil, draft.ABSTRACTBathimetric USV is a portable unmanned vehicle with small dimension which is capable of carrying out bathymetric measurements. This study is intended to design the stable USV hull for bathymetric surveys in calm waters. The hull is designed as a monohull and will be operated in freshwater, only consider the vertical static stability for heave motion (caused by the total weight of USV) and small angle roll without the influence of wind and currents. USV hull is designed with 1.64 meters length, 0.52 meters breadth, and 0.26 meters depth which has U-shaped at two-thirds of the aft hull bottom and U-shaped at one-third of fore hull bottom. The drafts plan of 0,08 m, 0,12 m, and 0,16 m have good vertical static stability with block coefficient from 0.68 to 0.71, so the designed USV is not classified as a fast ship. USV total weight is recommended between 36 to 83 kg. From the dimensions, weight, and large block coefficient the designed USV hull can be categorized as a unmanned vessel with low speed. Therefore, it is suitable for bathymetric USV.Keywords: bathimetric USV, heave, small angle roll, draft
Pemodelan pada Proses Cyclostationarity Berdasarkan Data Pasut Cilacap Tahun 2007-2015
Authors: Cendani Larasati S. , Perbani N.M.R.R. Cahya , Sawitri Kania
Published: June 2018

ABSTRAK Sesuai prosedur dalam penentuan MSL sejati, pengamatan pasut dilakukan secara terus-menerus selama 18,61 tahun dengan selang waktu satu jam tanpa jeda. Pengamatan pasut tersebut bukanlah suatu hal yang mudah dan hampir tidak dapat untuk dilakukan, MSL yang digunakan untuk kepentingan teknis umumnya ditentukan berdasarkan data pengamatan pasut periode pendek selama 15 atau 29 hari. Periode pendek tersebut memiliki keterbatasan dalam mengakomodasi seluruh faktor yang mempengaruhi MSL. Hipotesis pada penelitian ini MSL bulanan juga memiliki sifat cyclostationarity berdasarkan penelitian pasang tinggi di Benoa, Bali yang memiliki sifat yang sama. Penelitian ini bertujuan memodelkan terjadinya proses cyclostationarity untuk dijadikan sebagai model koreksi mean sea level bulanan dan untuk mengetahui variasi yang terjadi. Pemodelan dilakukan menggunakan fungsi gelombang dua konstanta pasut periode panjang Sa dan Ssa menggunakan analisis harmonik kuadrat terkecil melalui Deret Fourier. Dari penelitian yang telah dilakukan diketahui bahwa model gelombang yang dihasilkan sudah 80% mewakili perilaku MSL bulanan dan simpangan maksimum terhadap MSL bulanan rata-rata sebesar 245 mm. Kata kunci: MSL bulanan, cyclostationarity, fungsi gelombang ABSTRACT In procedure to determine the true mean sea level (MSL), hourly tide measurement should be taken for 18,61 years continuously. That such measurement is not simple and barely possible to establish. In most technical cases, MSL is determined from shot period measurement 15 or 29 days. The limitation of that such short period data is in accommodating all factors with action MSL. In this study the monthly MSL is a cyclostationarity process like spring tides in Benoa, Bali is taken as the hypothesis. This study directed to model cyclostationarity process to build the model of monthly MSL and to find it’s variation. The modeling is accomplished using wave function two long period constituents (Sa and Ssa). Least square harmonic analysis by means of Fourier series is applied. It is found that the wave model from this study represent about 80% of monthly MSL behavior and the average of maximum deviation is 245 mm. Keywords: monthly MSL, cyclostationarity, wave function