bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN E-LEARNING PADA MATA KULIAH TEKNIK PELAPISAN
Authors: Majid Aldi H , Sukrawan Yusep , Komaro Mumu
Published: June 2019

Tujuan dengan adanya e-learning dalam mata kuliah teknik pelapisan untuk mempermudah mahasiswa dalam proses pembelajaran, menghasilkan struktur menu dan cara pengoprasian yang mudah dan menghasilkan prototype dalam pembuatan e-learning pada mata kuliah teknik pelapisan. Kesulitan mahasiswa dalam contoh pengaplikasian materi yang telah dipelajari maka dengan adanya e-learning ini dapat mempermudah mahasiswa dalam mengakses materi yang kurang paham. Metode penelitian yang dilakukan pada penelitian ini menggunakan design based research. Hasil produk e-learning berbasis moodle pada mata kuliah teknik pelapisan ini dapat digunakan sebagai media pembelajaran.Struktur menu yang dihasilkan pada e-learning ini adalah home berisikan pengenalan tentang e-learning, site page berisikan peserta, kalender, dan catatan. Halaman yang bisa digunakan untuk memperluas jaringan, dan course merupakan bagian terpenting dalam e-learning. E-learning berisikan materi, chat, forum, quis, dan lain-lain. Hasil validasi ahli media pada produk  pengembangan e-learning ini adalah sangat baik artinya layak digunakan. Hasil validasi ahli materi, materi yang digunakan sangat baik artinya materi layak digunakan pada mata kuliah teknik pelapisan. Hasil uji terbatas pada mahasiswa prodi teknik mesin D3 menunjukkan pada kategori sangat baik, artinya bahwa produk e-learning ini mudah untuk digunakan.
KONTRIBUSI PRAKTIK KERJA INDUSTRI TERHADAP KESIAPAN PESERTA DIDIK DALAM BERWIRAUSAHA
Authors: Firdaus Riksa F , Kusumah Inu H , Sulaeman Sulaeman
Published: June 2019

Tujuan penelitian ini untuk mengetahui gambaran pelaksanaan praktik kerja industri peserta didik SMKN 8 Bandung, kemudian mengetahui gambaran kesiapan peserta didik dalam berwirausaha, dan mengetahui kontribusi praktik kerja industri terhadap kesiapan peserta didik dalam berwirausaha. Metode penelitian yang digunakan adalah metode deskriptif analitik dengan pendekatan kuantitatif. Populasi pada penelitian ini adalah kelas XI TSM, pengambilan sampel menggunakan teknik simple random sampling. Teknik pengumpulan data menggunakan angket dengan skala likert. Berdasarkan hasil penelitian, gambaran pelaksanaan praktik kerja industri termasuk ke dalam kategori baik, artinya lebih dari setengahnya peserta didik telah melaksanakan praktik kerja industri dengan baik sesuai dengan pedoman laporan praktik kerja industri. Gambaran kesiapan peserta didik dalam berwirausaha termasuk ke dalam kategori baik, artinya lebih dari setengahnya peserta didik siap dalam berwirausaha. Terdapat hubungan atau korelasi antara praktik kerja industri dengan kesiapan berwirausaha pada tingkat hubungan termasuk kategori cukup kuat. Pelaksanaan praktik kerja industri mempunyai kontribusi yang signifikan terhadap kesiapan peserta didik dalam berwirausaha.
KOMPETENSI MAHASISWA TEKNIK MESIN DIPLOMA 3 DAN RELEVANSI DENGAN DUNIA KERJA
Authors: Sutrisno Yohanes T.A. , Rohendi Dedi , Permana Tatang
Published: June 2019

Penelitian ini bertujuan untuk mengetahui kompetensi mahasiswa dan relevansi dunia kerja lulusan Program Studi Teknik Mesin D3 Konsentrasi Otomotif.  Kompetensi yang tertera pada Surat Keterangan Pendamping Ijazah adalah kompetensi mata kuliah dasar teknik mesin dan kompetensi mata kuliah dibidang otomotif yang minimal dimiliki oleh lulusan. Kompetensi ditinjau dari capaian pembelajaran mahasiswa dalam bidang dasar teknik mesin dan bidang otomotif dilihat dari beberapa mata kuliah yang tertera di SKPI. Relevansi  dunia kerja yang dimaksud adalah bidang kerja, dan jabatan lulusan di dunia kerja. Relevansi bidang kerja lulusan diukur dari deskripsi pekerjaan, jabatan dan bidang pekerjaan lulusan. Metode yang digunakan dalam penelitian ini adalah metode survei deskriptif analitik dengan pendekatan kuantitatif. Penelitian ini dilakukan pada mahasiswa dan lulusan Program Studi Teknik Mesin D3 Konsentrasi Otomotif. Sampel diambil dengan teknik sampling purposive sebanyak 35 orang. Instrumen penelitian menggunakan kuesioner dan dokumentasi.  Hasil penelitian ini diperoleh bahwa kompetensi mahasiswa sudah baik dengan persentase kompetensi mata kuliah dasar teknik mesin sebesar 72,2 % (baik), dan kompetensi mata kuliah bidang otomotif sebesar 82,7 % (baik). Sedangkan  relevansi dunia kerja lulusan di peroleh hasil 46% lulusan yang bekerja, 26% jabatan lulusan menjadi teknisi, dan relevansi bidang kerja dengan jurusan saat kuliah adalah sebesar 60,9 % sehingga bisa relevan dengan dunia kerja.
PENERAPAN MEDIA PEMBELAJARAN ENGINE CUTTING SEPEDA MOTOR TIPE AL 115 F/FC PADA KOMPETENSI MEMAHAMI CARA KERJA ENGINE EMPAT LANGKAH DI SMK
Authors: Aprianto Ary , Komaro Mumu , Sriyono Sriyono
Published: June 2019

Penelitian ini bertujuan untuk memperoleh data tentang hasil belajar siswa dengan penerapan media pembelajaran engine cutting sepeda motor. Penelitian ini menggunakan metode pre eksperimen dengan one group pretest-posttest design. Populasi pada penelitian ini adalah siswa kelas X TBSM di SMKNegeri 8 sebanyak 180 orang. Sampel menggunakan purposive sampling dengan metode nonprobability sampling sebanyak 33 orang. Instrumen penelitian menggunakan kuesioner dan tes tulis. Hasil penelitian menunjukkan pembelajaran dengan penerapan media pembelajaran engine cutting sepeda sebanyak 94% siswa sudah belajar dengan tuntas. Penggunaan media engine cutting sepeda motor dapat meningkatkan hasil belajar siswa dengan peningkatan hasil belajar (N-gain) dengan nilai 0,68 yang termasuk dalam kriteria sedang.
RELEVANSI MATA PELAJARAN PEMELIHARAAN MESIN KENDARAAN RINGAN DENGAN KOMPETENSI KERJA DI INDUSTRI OTOMOTIF
Authors: Ridho Rasyid , Hamdani Aam , Noor Ridwan A. M.
Published: June 2019

Penelitian ini bertujuan untuk mendeskripsikan pemetaan relevansi antara mata pelajaran pemeliharaan kendaraan ringan dengan kompetensi kerja di industri otomotif. Penelitian ini yaitu penelitian deskriptif. Teknik pengumpulan data yang digunakan observasi dan dokumentasi. Hasil  penelitian ini, yaitu mata pelajaran PMKR kelas XI belum mencapai standar kompetensi SKKNI dengan hasil rasio ketepatan sesuai sebesar 0,49, dan untuk mata pelajaran PMKR kelas XII memiliki kesesuaian dengan kompetensi kerja di Industri Otomotif, dengan rasio ketepatan sebesar 0,1 yang dapat diartikan relevan. Kesimpulannya bahwa relevansi mata pelajaran PMKR dengan kompetensi industri otomotif sebagian besar sudah relevan. Namun belum bisa dinyatakan sebagai dokumen yang baik, karena masih ada sebagian materi mata pelajaran PMKR yang belum relevan dengan kompetensi kerja di industri otomotif.
MOTIVASI DAN HASIL BELAJAR SISWA SMK JURUSAN TEKNIK KENDARAAN RINGAN
Authors: Romansyah Romansyah , Kusumah Inu H. , Permana Tatang
Published: June 2019

Penelitian ini bertujuan untuk mengetahui perbedaan motivasi dan hasil belajar antara siswa kelas XI reguler dengan siswa kelas industri jurusan Teknik Kendaraan Ringan SMKN 6 Bandung dalam mengikuti mata pelajaran PKKR. Metode yang digunakan dalam penelitian ini adalah metode komparatif dengan pendekatan kuantitatif. Penelitian ini dilakukan terhadap 67 responden pada peserta didik kelas XI paket keahlian Teknik Kendaraan Ringan. Teknik pengumpulan data menggunakan angket tertutup dengan menggunakan skala Likert dan tes hasil belajar berupa pilihan ganda. Hasil dari penelitian menunjukkan terdapat perbedaan motivasi yang signifikan antara siswa kelas XI reguler dan siswa kelas XI industri. Motivasi belajar siswa kelas XI reguler sebesar 59% atau cukup tinggi dan motivasi belajar siswa kelas XI industri sebesar 77% atau tinggi. Terdapat perbedaan hasil belajar yang signifikan antara siswa kelas XI reguler dengan siswa kelas XI industri dalam mengikuti pembelajaran mata pelajaran PKKR. Hasil belajar kelas XI reguler memiliki nilai rata-ratanya 69,5. Rata-rata hasil belajar kelasa XI industri sebesar 74. Siswa kelas XI reguler sebanyak 5,4% siswa yang mendapatkan nilai tertinggi dan kelas XI industri sebanyak 20%. Disimpulkan bahwa motivasi dan hasil belajar siswa kelas industri lebih baik dibandingkan dengan kelas reguler.
Why Do(n’t) People Move When They Get Older? Estimating the Willingness to Relocate in Diverse Ageing Cities
Authors: Haacke Hannah C. , Enßle Friederike , Haase Dagmar , Helbrecht Ilse , Lakes Tobia
Published: June 2019

Two of the dominant processes shaping today’s European cities are the ageing and diversification of the population. Given that the range of action usually decreases in later life, the living environment around the place of residence plays an important role in the social integration of the older generation. Hence, spatial patterns of residence indicate the extent of opportunities for the older population to engage in urban life and, therefore, need to be addressed by urban planning and policy. The aim of this article is to study the interrelation between diversity in later life—in terms of migrant history, gender, social class, and age—as well as planned and actual (past) movements of elders. We have chosen Berlin as a case study and draw from a quantitative survey with elders (age 60+) from diverse backgrounds (N = 427). Our results from descriptive analysis and statistical hypothesis tests show that age impacts people’s past and planned movement; we observe a peak in the decisions to move at the age of 65–75 and a drop in the inclination to move among people over 80. None of the other factors is similarly influential, but we observe appreciable tendencies regarding the impact of gender and social class on planned movements. Our study suggests that variables other than classic socio-demographic data, such as apartment size, rent, social networks, and health, and their interrelations may offer a promising starting point for achieving a full picture of older people’s movement behaviour.
Assessing Liveable Cities for Older People in an Urban District in Turkey Using the Analytical Hierarchy Process
Authors: Aksoy Ercüment , Korkmaz-Yaylagul Nilufer
Published: June 2019

The key concepts availability and accessibility have been taken into consideration in urban studies as well as the health and social aspects of ageing. These terms are in close relation with the “active ageing”, “age-friendly city” and “liveable city” concepts. These concepts were created by the UN, the World Health Organization, and other institutions aiming to increase the quality of life of older individuals and to regulate their living environments in an optimal way for an active and independent life. Improving accessibility and availability of facilities for older people in urban areas is crucial to ensure that older people are able to meet their own needs as well as prevent their exclusion from society. The planning of cities that prevents the social exclusion of older people and provides an independent way of living is the main objective of the concept of liveable cities. From this point of view, this study aims to evaluate the existing opportunities in an urban area in the context of liveability. Out of the multi-criteria decision-making models, analytic hierarchy process (AHP) and geographic information systems (GIS) were therefore used in this research. Three main districts of Kepez, with the highest population of older individuals, have been chosen. According to the findings of the study, the weight of health services has the highest score compared to other criteria. The liveability scores and grading of the districts were obtained using the AHP matrix. In the study, it was concluded that a multi-criteria analysis could be carried out with quantitative data. The real land use and the close environment of the research area should also be considered in the evaluation process.
THE ROLE OF PARASTERNAL MEDIASTINOTOMY IN THE DIAGNOSIS OF MEDIASTINAL TUMORS
Authors: Pikin O. V. , Ryabov A. B. , Alexandrov A. O. , Vursol D. A. , Amiraliev A. M.
Published: June 2019

Parasternal mediastinotomy is a surgical method of morphological verification of mediastinal tumors, widely performed in oncological clinics. The article provides information about the method of implementation and the results of parasternal mediastinotomy for malignant tumors of the mediastinum.

Purpose of the study. Evaluation of the results of parasternal mediastinotomy for morphological verification of mediastinal tumors.

Patients and methods. The study included 77 patients who for the period from 2008 to 2018. 80 parasternal mediastinotomies were performed with a biopsy of a mediastinal tumor in the conditions of the Department of Thoracic Surgery of the P. Hertsen Moscow Oncology Research Institute. At the stage of preoperative examination, all patients underwent standard diagnostic studies: computed tomography of the chest, abdominal cavity, and a comprehensive ultrasound. In the case of the presence of the endobronchial component of the tumor, fibrobronchoscopy was performed. MRI of the brain was performed in patients with neurological symptoms. 12-lead ECG, echocardiography, and a study of the function of external respiration were performed to assess the functional status of patients.

Results. The final histological diagnosis was made in 76 of 77 (99%) patients. The clinical diagnosis of lymphoma was set in 66, thymoma — in 6 patients, lung cancer with affection of mediastinal lymph nodes — in 4 patients, mediastinal tumor — in 4 patients. In 24 patients (31%), operations were preceded by other attempts at morphological verification. In 12 patients — mediastinal tumor biopsy under ultrasound control, in 3 — parasternal mediastinotomy, in 2 — transthoracic mediastinal tumor biopsy combined with biopsy of supraclavicular lymph node under ultrasound control, 2 — biopsy of supraclavicular lymph node under ultrasound control, in 1 — mediastinum tumor biopsy under control. — chest wall biopsy, in 1 — open biopsy with thoracotomic access, in 1 — tonsil biopsy, in 1 — trachea biopsy. In all cases, the indication for performing a parasternal mediastinotomy was an insufficient amount of material for carrying out a complete immunohistochemical study.

Conclusion. Parasternal mediastinotomy is a safe and reliable method of morphological verification of the formations of the anterior mediastinum and para-aortic region. In case of the ineffectiveness of transthoracic biopsy under the control of ultrasound or CT navigation, the performing of parasternal mediastinotomy allows to establish a morphological diagnosis and to begin a specific treatment in the shortest possible time.
THE RESULTS OF MODULAR ENDOPROSTHESIS OF PERIACETABULAR REGION IN TUMOR LESIONS OF THE ACETABULUM AND HIP JOINT
Authors: Iluridze G. D. , Karpenko V. Yu. , Derzhavin V. A. , Bukharov A. V.
Published: June 2019

Surgical treatment of patients with tumoral defeat of pelvic bones, of preacetabular region, in particular, is one of the most challenging topics of modern oncorthopedics. Currently, one of the most modern methods of reconstruction of the pelvic bones is the use of modular endoprostheses based on the conical leg, the advantage of which is the ability to intraoperatively simulate an endoprosthesis that best meets the specific clinical situation.

Purpose of research. To assess the benefits of modular endoprosthesis of the acetabulum in patients with tumoral defeat periacetabular region.

Patients and methods. Within the period of 2011–2018 30 patients underwent surgical treatment in form of periacetabular resection with a modular endoprosthesis reconstruction in P.Hertsen Moscow Oncology Research Institute – Branch of National Medical Research Radiological Centre of Ministry of Health of Russian Federation. There were 13 men (43%) and 17 women (57%). The median age was 45 years (23–63 years). Primary bone cancers were in 19 (63%) patients, giant cell tumors in 5 (17%), locally advanced soft tissue sarcoma in 1 (3%), solitary metastases of kidney cancer in 2 (7%), and recurrent sarcomas after previous surgical treatment in 3 (10%) patients.

Results. The average duration of the operation was 310 min (145–520 min), the volume of intraoperative blood loss was 5520 ml (600–20 000 ml). The positive edge of resection according to the results of the planned morphological study was revealed in 3 (10%) patients. The average follow-up period was 36 months (4-73 months). Disease progression in terms of 6 to 40 months was revealed in 10 (33%) patients. 8 (27%) patients from disease progression. Complications of different types were diagnosed in 11 (37%) patients, among whom infectious complications prevailed 9 (30%). The average value of the functional results on a scale MSTS accounted for 59% (15 to 82%).

Conclusion. The use of modular systems of endoprosthesis replacement of the acetabulum and hip joint in tumor lesions is a promising surgical technique that allows to achieve adequate functional results with a comparable number of postoperative complications.
MEDICAL AND STATISTICAL CHARACTERISTICS OF BREAST CANCER IN ST. PETERSBURG FEMALE RESIDENTS
Authors: Romanenkov N. S. , Hizha V. V. , Movchan K. N. , Morozov U. M. , Gedgafov R. M. , Slobodkina A. S.
Published: June 2019

Purpose.To analyze the main medical and statistical parameters, allowing to evaluate the results of breast cancer treatment.

Patients and methods.Data on 4689 breast cancer (BC) patients were analyzed retrospectively. Inclusion criteria were: female, residence in St. Petersburg, diagnosis of BC established in 2011, 2012. The study also includes information on the options of BC surgical treatment, one-year mortality in breast cancer patients and index of the contingent accumulation in St. Petersburg in 2011–2017. For statistical data processing Statistica 12.0 for Windows, Population Cancer Register and MedInfo-4 were used. The differences in the groups of studies were considered statistically significant at p < 0.05.

Results.The prevalence of breast cancer among women in St. Petersburg varies from 532.6 per 100 000 population in 2011 to 545.00/0000 in 2012. In 2011 the incidence of BC in women in St. Petersburg was 46.210/0000 (standard deviation 1.05) and in 2012 – 49.50/0000 (standard deviation 1.05). The mean age of breast cancer patients is 64 years (standard deviation 12.25). Localization of a tumor in one of the glands was found in 4617 (98.5%) clinical observations. In 2,846 (60.7%) cases, the tumor sizes varied from 2 to 5 cm. Signs of infiltrative ductal carcinoma were histologically verified in 3689 (80%) cases. The proportion of single-stage breast reconstruction after mastectomy in the overall structure of surgeries in breast cancer patients increased in 2011–2017 more than 6.5 times. The 5-year survival rate in study groups was 64.4% and 63.3%.

ConclusionsThe main statistical parameters of medical care (MC) analysis in breast cancer patients in St. Petersburg in 2011–2017 allow to state generally positive trends in the anticancer fight organization. The increase of the breast cancer incidence rates is partly due to the improved quality of examination and treatment of patients through the creation in the city of a system of high-tech MC, as well as to the particularly wary of doctors in detecting breast tumors.
Reasons for Reduced Learning Motivation in Students with Attention Deficit Hyperactivity Disorder
Authors: Katunova V.V.
Published: June 2019

The article discusses the study of the relationship of ADHD in children and adults with their learning motivation at the neurological and behavioral levels. On the basis of the results of research presented in modern foreign literature, two categories of reasons for the decline in learning motivation among students with ADHD are identified: external and internal. The purpose of this article is to emphasize that the system of motivation in patients with ADHD has deeper impairments than is commonly believed due to neurological disorders of the brain, as well as complex social problems, and present these results as an explanation of motivational and educational problems faced by students with ADHD. The article also presents possible directions for coordinating the reasons for the decline in academic motivation in ADHD and psychological theories of its formation (SDT, AGT and SCT). The possibilities of applying these theories for psychological and pedagogical solutions to the problems of motivation among students with ADHD are shown. The results of the analysis of the reviewed scientific papers indicate the need for a comprehensive account of the factors that reduce motivation in developing a system of recommendations for students with ADHD – for organizing their learning environment and planning the individual trajectory of their development.
The experience of Application of Information and Communication Technologies (ICTs) as a Tool to Enhance Learning Motivation
Authors: Prudnikova T.A. , Poskakalova T.A.
Published: June 2019

The analytical review of foreign studies focuses on the utilization of information and communication technologies (ICT) in education. It considers the most popular networking technology currently used in the educational process in many countries of the world. It also exemplifies the studies demonstrating that the use of ICT can enhance learning motivation and improve academic performance among students of different ages.
The Problem of Influence of Children’s Birth Order in the Family on Their Intellectual Abilities and Personality Traits
Authors: Lapteva N.M. , Valueva E.A. , Shepeleva E.A.
Published: June 2019

The article analyses theoretical approaches and empirical research of the influence of the children’s birth order in the family on their intellectual and creative abilities, achievements in education, personality traits, behaviors and social preferences. It is shown that the results of the studies vary depending on the method of data analysis - the effect of decreasing intelligence while increasing the birth sequence number detected when comparing indicators of large numbers of children with different birth order from different families, and generally not detectable in intra-family analysis data. To explain the differences obtained the authors used three basic theoretical models: a model of merge, the model of resource depletion and impurity model. Due to differences in birth order personality traits have more pronounced differences in the cognitive sphere. Research confirms that according to the results of the personal questionnaire «Big five» firstborns display more pronounced «honesty», and younger children-«kindness» and «openness» to experience. Individual work on features of social interaction of senior and subsequent children demonstrated a great ability of younger children to cooperation. Despite the fact that the prognostic significance of identified effects in large samples is not as great as in individual families, results may have practical significance for the pedagogical and psychological work with children.
In Memory Jan Van Dijk Famous Netherland Psychologist (1937–2018)
Authors: Basilova T.A. , Paykova A.M.
Published: June 2019

The article is dedicated to the memory of the famous Netherland scientist in the field of special education, professor Johannes Van Dijk, who died at January 23, 2017 at 81 years old. Describes the main stages of his professional biography in field of Deafblind Education.
Value Determinants of Readiness for Volunteer Activities in Individuals
Authors: Palkin K.A.
Published: June 2019

The article provides a review of published works on psychological components of personality in volunteers. The analysis is accompanied with the outcomes of a study aimed at revealing psychological determinants of volunteering. The study involved a survey of 400 people (including 300 volunteers) based on the “Terminal Values Scale” technique (by I.G. Senin).Statistical data analysis confirmed the hypothesis about the fundamental differences in the structure of human values of volunteers and non-volunteers. Moreover, insignificant gender influences were detected as well as a weak correlation between the length of volunteering experience and certain values that occupied different positions in the value hierarchies of newcomer and experienced volunteers. The paper concludes that research in this field needs to be continued in order to achieve a more detailed picture of the revealed differences and to explore other determinants of volunteering in the structure of the respondents’ personality, so that a truly reliable image of the modern volunteer’s collective personality would become available.
“New Biology” and Its Educational Outcomes
Authors: Chudinova E.V.
Published: June 2019

The paper presents data of a study on the effectiveness of an experimental school course in biology based on the principles of Davydov—Elkonin developmental learning in comparison with traditional courses. The study involved 395 students of 5th, 6th, and 9th classes. The results show that children can be more successful at achieving not only subject, but also metasubject educational outcomes like reading literacy, ability to work with signs, symbols and models etc, which are all required by the federal state education standard, if the content of education is changed in such a way that the integral system of key concepts becomes the subject matter, presented not as a means of describing an object, but rather as a basis for its transformation by students. When learning is organised that way, it provides an opportunity for primary school students with underdeveloped reading skills to compensate for the lack of reading literacy, although it will still be hard for them to master subject concepts successfully enough.
Development and Approbation of Methods for Diagnostics of Predisposition to Monosemantic or Polysemantic Context Generation
Authors: Khokhlov N.A. , Laskov G.D.
Published: June 2019

This article focuses on the development of methods to measure personality and cognitive predisposition to monosemantic or polysemantic context generation (PCG).In accordance with the concept of V.S. Rotenberg, we assumed that PCG was connected with manual functional asymmetry. We developed four tests: one was designed to measure personality PCG, the other three measure cognitive PCG. Approbation samples consisted of 160—736 participants. Cronbach's alpha (0.67—0.93) and split-half coefficient (0.72—0.93) were calculated for all tests, for two of them test-retest reliability (0.47—0.91) was measured. Variance of personal PCG on 21.7% is explained by the variance of personality traits “reticence-sociability” and “concreteness-abstractness”. Personality and cognitive PCG are interconnected, but they have a fair amount of specificity. Manual functional asymmetry is weakly connected with personal PCG (not more than 1.5% of the common variance) and is not connected with cognitive PCG
Arabidopsis thaliana Bitkisi ile Pseudomonas putida Bakterisi Arasındaki Etkileşimin in vitro Koşullarda Belirlenmesi
Authors: AKKAYA Özlem
Published: June 2019

A.
thaliana genomu dizilenmiş genetik, biyokimyasal ve
biyoteknolojik çalışmalarda yaygın olarak kullanılan model bir bitkidir. P. putida bakterisi ise bitki köklerinde
kolonize olabilen, genomu dizilenmiş, bitki büyümesini teşvik eden, patojenik
olmayan ve bitki-bakteri etkileşimlerinin anlaşılması için model olmaya aday
rizosferik bir bakteridir. Bu nedenle, bu çalışmanın amacı A. thaliana’nın in vitro
çimlenmesi ve fideciklerinin büyümesi üzerine P. putida’nın etkisinin değerlendirilmesidir. Bu amaçla, yüzey
sterilasyonu yapılmış A. thaliana
tohumlarının inokülasyonu için 2x103-2x105 CFU/ml
aralığındaki bakteri konsantrasyonları pipetleme metodu kullanılarak denenmiştir.
Ayrıca, aynı bakteriyel süspansiyonlar 3, 5, 10 ve 14 günlük in vitro koşullarda çimlendirilmiş
fideciklere de uygulanmıştır. Bu araştırma alanı, bitki-bakteri
etkileşimlerinde inokülasyonun öneminin anlaşılmasına önemli bir yarar ve bunun
yanı sıra daha sonraki kapsamlı çalışmalar için bir katkı sağlayacaktır.
Dahası, sonrasında bitki-bakteri etkileşimleri aracılığıyla biyoremediasyonun
başarılmasına yardımcı olacaktır.
Comparison Some Microbiological and Physicochemical Properties of Freeze Dryed and Spray Dryed Milk Powder
Authors: YERLİKAYA Sabire , ŞEN ARSLAN Hülya
Published: June 2019

In this research,
some microbiological
and physicochemical properties of milk powder produced by
freeze dryer and spray dryer were determined during the storage
period. Firstly,
milks were divided into two groups. First group was dryed with freeze dryer.
Second group was dryed with spray dryer. Total aerobic mesophilic bacteria,
mould-yeast, total coliform and fecal coliform, moisture, hunter
colour determination, water activity, pH analyses were performed in 2., 4. and 6. days of storage at room temperatures. Water absorption index, water
solubility index, protein and microscopy analysis was performed
in 2.day, 6.day and 6.day of storage, respectively. Moisture, water activity,
microbiological analysis, L value and
water absorption index values of freeze dryed milk powders were found lower
than spray dryed samples in all days of storage. Microbiological quality of
freeze dryed milk powder is better. It was thaught that the milk powder produced
by freeze drying may have a longer shelf life at room temperature.
Endometriosis-assEndometriosis-associated ovarian tumors: morphological and immunohistochemical features
Authors: Bayramova N. N. , Protasova A. E. , Raskin G. A. , Sobivchak M. S. , Yarmolinskaya M. I.
Published: June 2019

Background. In 2016, the World Health Organization published an updated version of the Histological Classification for ovarian tumors presenting a new category of endometriosis-associated tumors. The predictors of malignant transformation of endometriosis have not been clearly defined so far.

Purpose. The search for histological and immunohistochemical markers of endometriosis-associated malignancy.

Materials and methods. 28 female patients with endometrioid ovarian cancer and 11 patients with clear cell ovarian carcinoma were enrolled. Histological and immunohistochemical studies were carried out using conventional techniques. Immunohistochemistry was applied to determine the hormone receptor status: expression of steroid hormone receptors, BAF250a (ARID1A), PTEN, P-catenin, MSH6, PMS2, р-53, WT-1, proliferative index (Ki-67). Microsatellite instability (MSI) testing was conducted according to the standard protocol.

Results. In all cases of ovarian cancer, histological examination showed one of the endometriosis features. Atypical endometriosis was found in 39 % (11 / 28) of endometrioid tumors and in 9% (1/ 11) of clear cell carcinomas. Endometrioid ovarian cancer was found to be ER (74±7,8%) — and PR (67±5,4%) — positive; Ki-67 index was 68,2±3,7 %; loss of BAF250a (ARID1A) expression was observed in 14% (4/ 28), loss of PTEN expression in 29 % (8 / 28), nuclear expression of P-catenin in 32% (9/28) of cases. Loss of MMR expression was detected in 7% (2/28) of cases. MSI was found in one case only, which was also associated with loss of expression of BAF250a (ARID1A) and MSH6. Clear cell carcinoma of the ovary showed histological criteria for endometriosis; however, there were no changes immunohistochemical markers expression that were typical for endometriosis-associated malignancies. It could be due to a small number of patients in the group so further research is needed.

Conclusion. Atypical endometriosis may be a morphological precursor of endometrioid and clear cell carcinoma of the ovary. Comprehensive assessment of a marker panel consisting of BAF250a (ARID1A), P-catenin, PTEN, p53, Ki-67 index, PMS2 and MSH6 will allow improving the diagnosis of atypical endometriosis and endometriosis-associated ovarian cancer.
Mandibular reconstruction of the chin area in patients with tumors of the maxillofacial region and oral mucosa
Authors: Kropotov М. А. , Sobolevsky V. A. , Dikov Yu. Yu. , Yakovleva L. P. , Khodos A. V. , Gavrishchuk P. A.
Published: June 2019

Background. Locally advanced squamous cell carcinoma of the oral cavity invades the mandible in 13–38 % of cases. Even a small segmental resection of the mandible, for instance, in the chin area, causes significant functional and cosmetic impairment and requires immediate reconstruction of the bone defect. Currently available methods of defect closure require a comparative assessment.

Materials and methods. This article is based on the outcome data from patients with mandibular tumors treated from 1998 through 2018. We identified 471 cases of mandibular surgery including marginal resection and midline mandibulotomy; 203 (43.1 %) patients underwent segmental resection. Of them, we selected 99 patients with an isolated chin defect combined either with a mandibular body defect or with a subtotal defect in the mandible.

Results. In this study, we analyzed the treatment outcomes in patients with primary and secondary mandibular tumors involving the chin as the most difficult for reconstruction from the point of view of the surgeon and the most important for the patient from the functional and aesthetic point of view.

Conclusions. A mandibular defect located in the chin area requires immediate reconstruction. The preferable method of defect closure is the application of a reconstruction plate with a musculocutaneous flap or implantation of vascularized bone grafts. Implantation of a fibular free flap is preferable for the closure of extensive mandibular defects involving the chin area.
Association between carbohydrate consumption with telomere length based on plasma malondialdehyde in Minangkabau male
Authors: Nazulis Weni F. , Sulastri Delmi , Lestari Yuniar
Published: June 2019

Background: Life expectancy was one indicator of human development index in the health sector, one of which was affected by the telomere shortening process. There were many factors that cause shortening of telomere, including an imbalance of carbohydrate consumption then oxidative stress. The study aimed to examine the association between carbohydrate and carbohydrate simplex (sucrose) consumption with telomere length based on plasma malondialdehyde in Minangkabau male.Methods: The study was cross-sectional with 97 samples from male civil servant, Minangkabau ethnic, 40-50 years old in Padang City. Carbohydrate and sucrose consumptions were obtained through semiquantitative food frequency questionnaire, plasma malondialdehyde examination with thiobarbituric acid test and telomere length measured by quantitative polymerase chain reaction using O'Challagan and Fenech method.Results: The result showed mean of telomere length was 550.43±188.47 bp; mean of carbohydrate consumption 1280.97±433.57 kcal or 48.80±16.52%; mean of sucrose consumption 179.40±126.61 kcal or 6.83±4.82% and mean plasma malondialdehyde 66.91±13.93 nmol/ml. The association of carbohydrate consumption with telomere length based on plasma malondialdehyde was obtained p-value = 0.714, 0.908 and 0.903. The relationship of sucrose consumption with telomere length based on malondialdehyde was obtained p-value=0,667 and 1,000. Differences in mean telomere length in various categories of carbohydrate and sucrose consumption obtained p-value = 0.547 and 0.559.Conclusions: There was no significant association between carbohydrate and carbohydrate simplex (sucrose) consumption with telomere length based on plasma malondialdehyde of Minangkabau male; and no significant difference in telomere length in different categories of carbohydrate consumption and different sucrose consumption.
Cardiovascular profile of patients with chronic kidney disease
Authors: Mahishale G. S. , Allolli Deepa , Patil Anand , G. Basavaraj P. , Shetagar Sachin , Talikoti Satish
Published: June 2019

Background: Frequency of fatal and nonfatal cardiovascular events increase even in early stages of chronic kidney disease (CKD). This study was aimed to understand the cardiovascular profile of patients with CKD.Methods: This observational study was conducted on patients who were admitted with chronic kidney disease in Sri Venkateswara Rama Narayan RUIA Government General Hospital, Tirupati. Patients were classified according to their severity of CKD. All patients had an electrocardiogram and echocardiogram. Results of various biochemical investigations, electrocardiogram and echocardiogram were compared between patients with mild, moderate and severe CKD.Results: Combined diabetes mellitus and hypertension was found to be the most common case of CKD in Authors patient population (43%), followed by diabetes mellitus alone (37%). Serum creatinine and blood urea nitrogen were found to be significantly higher and creatinine clearance and haemoglobin were significantly lower among patients with severe CKD. Electrocardiography revealed 50% had left ventricular hypertrophy (LVH), 30% had tall ‘T’ waves and 15 % had ST-segment changes. Mean inter-ventricular septal end diastole thickness and mean left ventricular mass was found to be significantly in patients with severe CKD as compared to mild CKD.Conclusions: Extensive cardiovascular evaluation of patients with CKD is warranted even if the classical symptoms are not absent and early cardiovascular rehabilitation should be instituted in such patients.
Correlation cyclooxygenase-2 expression and histopathological grading in locally advanced breast cancer
Authors: Maulidan Yasser , Syamsu Salman A. , Thabry Rudy , Abidin Zainal
Published: June 2019

Background: Cyclooxygenase-2 (COX-2) is involved in the carcinogenesis process and tumor progression into cancer. It has been reported recently, there was a COX-2 expression at breast cancer. Patients with a high level of COX-2 expression can have a local recurrence and decrease life expectancy, and an increase of COX-2 expression in tissue likelihood has prognostic value. This study aims to correlation cyclooxygenase-2 (cox-2) expression and histopathological grading in locally advanced breast cancer patient in AW Sjahranie Hospital in Samarinda city.Methods: This study was an observational study with crossectional design to analysis the correlation COX-2 expression and histopathological grading in patients with locally advanced breast cancer and using data analysis with the Chi-Square test.Results: The results showed that the correlation was not significant (P>0.05), where there was no correlation of COX-2 expression with histopathological grading (P=0.221) and there was no correlation with the last condition of patients (P=0.61). Although patients with breast cancer high grade and moderate grade percentages were significantly higher in positive COX-2 than in COX-2 negative expression.Conclusions: There were no correlation between COX-2 expression and histopathological grading and there was no significant relationship between COX-2 expression and the last condition, as evidenced by the statistical test results showing that the differences were not significant.
A cross sectional study regarding awareness of HIV/AIDS and practices of condoms among slum dwellers of Ajmer, Rajasthan, India
Authors: Meharda Bharat , Sharma Sanjeev Kumar , Keswani Mahesh , Sharma Rakesh Kumar
Published: June 2019

Background: People living in slums are often deprived of health-care facilities and it make them vulnerable to infection like HIV/AIDS. Health education and behavioural changes is pivotal for prevention of  HIV and HIV-related stigma.  Methods: It was community based cross sectional study carried among 288 slum dwellers of Ajmer, Rajasthan, India.Results: Out of 288 study subjects (male and females in the group of 15-54 years) 144 (50%) males and 144 (50%) females. Out of 288 study subjects 278 (96.53%) were heard about HIV/AIDS. Out of 249 study subject who were aware about condom, 107 (42.97%) study subjects [74 (56.06%) male and 33 (28.21%) female] were presently using of condom. out of 278 study subject who had ever heard about HIV/AIDS majority 215 (77.34%) subjects got the information regarding HIV/AIDS through TV/cinemaConclusions: Present study shows that the study subjects of slums at Ajmer has inadequate awareness regarding the HIV/AIDS and poor practice of condoms.
A prospective clinico‑hematological study in 100 cases of Pancytopenia in a tertiary care teaching hospital
Authors: M. Dougul Regis , R. Padmavathi
Published: June 2019

Background: Pancytopenia is encountered regularly in haematology practice, yet there exist only few published assessments of the frequencies of various aetiologies and this exhibit substantial geographic variation. Pancytopenia is a manifestation of many life- threatening diseases with a wide range of differential diagnosis. Haematological investigation forms the bedrock in the detection and management of patients with pancytopenia.Methods: This study is a prospective study conducted in the Institute of pathology and haematology, Madras medical college and Rajiv Gandhi Government General Hospital, Chennai during the period from August 2015 to August 2016 on 100 cases. Case selection is based on clinical features and supported by laboratory evidence. Peripheral smear was obtained and stained by Leishman stain for all cases and examined in detail. Bone marrow aspiration /biopsy was subsequently carried out under aseptic precautions.Results: Among the 100 cases studied, age of the patients ranged from 13 to 80 years with a slight male predominance. Most of the patients presented with generalized weakness and fever. The commonest cause for pancytopenia was aplastic anaemia followed by megaloblastic anaemia. The other causes include acute myeloid leukaemia, myelodysplastic syndrome, myelofibrosis, multiple myeloma, malarial parasite, miliary tuberculosis and osteopetrosis.Conclusions: Pancytopenia can be diagnosed, and its etiological profile can be ascertained with the help of detailed clinical history, meticulous physical examination and haematological investigations. Every attempt should be done to establish the underlying cause so that treatable conditions are diagnosed without delay and prognosis is improved.
Fatigue, depression and anxiety among nurses working in shift in a tertiary care hospital in South India
Authors: Kaliyaperumal Deepalakshmi , Elango Yaal , Santhanakrishnan Iswarya
Published: June 2019

Background: Shift work has become a social and economic necessity, as most sectors like the healthcare require round the clock operation. Extended and variable working hours leads to desynchronization of the body’s circadian rhythm. Thus, shift work is commonly associated with various physical and mental disorders like insomnia, fatigue, depression, anxiety, cognitive impairment, etc. The aim of the study was to assess the prevalence of sleep deprivation and hence, the levels of fatigue, depression and anxiety among shift working nurses.Methods: This cross-sectional study was conducted among shift working nurses. Sleep deprivation among 97 female and 3 male healthy nurses of age 20-50 years was assessed by Epworth Sleepiness Scale (ESS). Fatigue Severity Scale, Patient Health Questionnaire (PHQ-9) and Hamilton Anxiety Rating Scale (HAM-A) were used for assessing fatigue, depression and anxiety respectively. Level of Sleep deprivation, Depression and Anxiety were expressed in Proportion. Difference in fatigue levels during day and night shift was analyzed using Wilcoxon Signed-Ranks Test.Results: Analysis of ESS, showed, 69% of shift working nurses had poorer sleep quality. The level of fatigue experienced following a night shift work was significantly higher than that following day shift work (Z= 3.34, p = 0.0008). Moderate to severe depression and anxiety was observed in 15% and 16% of the nurses working in shift.Conclusions: Thus, shift work is inevitably associated with sleep deprivation. There exists an increased prevalence of fatigue, depression and anxiety among shift working nurses.
Serum magnesium and its association with vascular calcification in chronic kidney disease patients on haemodialysis
Authors: B. Prasanna K. , K. Sharavanan T. V. , S. Ekanthalingam , I. Kannan
Published: June 2019

Background: Cardiovascular disease is one of the leading causes of death in chronic kidney disease (CKD). It has been observed that haemodialysis patients have a high prevalence of cardiac risk factors with further risk due to abnormal mineral metabolism. A study has demonstrated that a higher serum magnesium significantly decreased the mortality risk in haemodialysis patients and lower serum Mg level has been found to be associated with increased mortality in them. The aim of the study was to characterize the relationship between Mg level and vascular calcification in CKD patients.Methods: It was a cross sectional study conducted in 100 CKD patients attending outpatient and inpatient ward of Tagore Medical College and Hospital, Chennai, Tamil Nadu, India. Serum magnesium levels will be measured using Xylidyl blue method. Carotid intimal medial thickness will be measured using Doppler.Results: In the study 10 patients did not show the sign of any calcification. Among the remaining 90 patients, 42 patients showed calcification and 48 patients showed stenosis. The statistical analysis showed a spearman correlation coefficient value of 0.201 thus showing only a weak association.Conclusion: The present study showed that only a weak relationship exists between the magnesium level and vascular calcification.
Prevalence of hypertension among school children in Kashmir, India
Authors: Bhat Rais A. , Wani Wasim A. , Dar Sheeraz A. , Wani Khurshid A.
Published: June 2019

Background: Over the last two decades, there has been increased awareness that hypertension in children may be a part of the spectrum of essential hypertension mainly linked to obesity epidemic. An increasing number of children and adolescents are being diagnosed with hypertension. Objectives of this study was to determine the prevalence of hypertension among apparently healthy school children residing in the valley of Kashmir.Methods: It was a community based cross sectional study was done over a period of one year in School going children aged 11 to 16 years from both urban and rural areas of Kashmir valley.Results: Thus, prevalence of hypertension was 5.1% and prevalence of prehypertension was 9.3%. Out of total 1600 children 1464 (91.5%) had a normal BMI, 72 (4.5%) were overweight and 64 (4%) were obese. In the prehypertensive group 114 (77%) had normal BMI, 18 (12.16%) were overweight and 16 (10.8%) were obese. In the hypertensive group 30 (36.6%) had normal BMI, 26 (31.7%) were overweight and 26 (31.7%) were obese.Conclusions: Our study reveals that hypertension is not uncommon in Kashmiri children. With globalization bringing more lifestyle modifications, children are exposed to multiple risk factors including obesity and family history of hypertension. We need to make people aware of these facts so that blood pressure measurement could be a part of routine health care check-up in children to detect it early and do necessary interventions.