bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing the Effectiveness of the Ketogenic Diet and Intermittent Fasting on 12-Weeks Weight Management in Women with Obesity
Authors: Zhang Zihan
Published: August 2023

The optimal dietary strategies for weight loss and maintenance have been at the center of debate for decades. Proponents of each camp presented their assertions, but they could not approve of one diet due to the sophisticated determinants and limited empirical evidence. This study aims to compare the effectiveness of the Ketogenic diet and Intermitting fasting concerning weight loss and risk factors of cardiovascular outcomes. Fifty-eight obese female participants agreed to participate in the 12-week randomized clinical trial followed by a 6-months observational period. The participants are randomly assigned to the ketogenic diet with an aggressive reduction in carbohydrate content or intermitting fasting that involve a restricted meal time. The results reveal that the ketogenic diet will result in rapid, short-term weight loss. In contrast, intermitting fasting will demonstrate better long-term weight maintenance and no noticeable correlation with reducing risk factors of cardiovascular diseases. In conclusion, this study indicates no absolute advantage to any single treatment.
The Connection Between Circadian Disruption and Cancer Risks
Authors: Han Yunting
Published: August 2023

The circadian rhythm is an essential biological mechanism that uses the 24-hour geophysical cycle to regulate thebody’s physiological and behavioral processes. It operates on a complex molecular interaction system that coordinatesgene expression, protein synthesis, and post-translational modifications. Disruption of this rhythm due to jet lag, shiftwork, and other unhealthy lifestyles has been linked to various health disorders, including cancer. Recent studies havesuggested a strong association between circadian disruption and development cancers, such as breast cancer, lungcancer, and glioblastoma. Understanding the connection between circadian disruption and cancer and the mechanismsunderlying this connection is essential for developing new cancer therapies. In this review, we provide an updatedaccount of key circadian mechanisms and their regulations on human health. We examine the adverse impact ofcircadian disruption on health using lung cancer and glioblastoma as case studies. Finally, we also discuss the potentiallypromising cancer treatment of chronotherapy, which targets components of the circadian cycle. We believe that futureresearch into circadian rhythm and cancer would encourage the progression into a new era of cancer medicine.
Inhibiting the Expression of Cyclin D1 Protein to Reduce the HBVDNA Level in CHB patients
Authors: Xu Yulei (Leon)
Published: August 2023

HBV virus is now affecting over 400 million people worldwide. Chronic Hepatitis B (CHB) is one of the significant clinical symptoms of HBV infection. Previous studies have reported that antiviral therapy is a practical method for patients. However, the current treatment has reached a bottleneck due to economic burden and drug resistance. As a practical component in ligustrum lucidum, ursolic acid has been found to have an antiviral effect. This study focuses on one particular mechanism of its effect. It tests its function in reducing the expression of Cyclin D1 protein to provide a possible reason for its ability to inhibit cell proliferation.
Optimal production with carbon trading market in China
Authors: Yin Mengzhang
Published: August 2023

As a significant carbon dioxide-emitting country globally, China has set a concrete short-term target of carbon dioxideemissions peak in 2030 and an ambitious long-term plan to reach carbon neutrality by 2060. One essential policy is toset up a carbon trading market to reduce high-pollution enterprises’ carbon emissions by rationally allocating carbonquotas among different firms and regions and setting carbon quotas trading market.In reality, firms obtain carbon quotas in three ways, initial allocation from the government, carbon market trading, andpurification. By using carbon quotas, firms are required to meet the limitation of carbon emissions by regulations. Tohelp firms make the cost-optimal decision in both short-term and long-term management, this paper focuses on theimpact and trading of carbon quota for emission-depending firms.The short-term optimal production model suits firms less than a year from meeting emission limitation requirements. Itis considered that during this time, firms cannot upgrade production equipment with less carbon emission but can onlysell or buy carbon quotas in the carbon trading market. Furthermore, this paper builds a carbon quota price predictingmodel based on the long-short-term memory neural networks(LSTM) method to help firms develop a better tradingstrategy. In the long term, firms can update their technique to less carbon-emitting production technology. Therefore,a long-term optimal production model is established, and variable purifying levels are discussed. Finally, this papercalculates the optimal production strategy under different restraints of carbon emission.
The inhibition of growth and metastasis of human pancreatic ductaladenocarcinoma by MART-10
Authors: Wu Guanchen
Published: August 2023

Previous studies demonstrated that MART-10, an analog to the active form of vitamin D3, has anti-cancer properties inanaplastic thyroid cancer (ATC). It can inhibit ATC’s metastasis by altering cadherin protein expression and preventingthe EMT process. This study aims to investigate the effect of MART-10 in a different system, pancreatic ductaladenocarcinoma (PDAC), in both in vitro and in vivo conditions. Methods: The study will use two known PDAC celllines. The cells will be treated with increasing MART-10 for various durations. In vitro metastasis will be measuredby trans-well migration and Matrigel invasion assay, in vitro proliferation will be measured by CCK-8 assay, and theinteraction between MART-10 and PDAC will be investigated with Western blot. Mice will be injected with tumorcells and treated with increasing MART-10; in vivo tumor growth and metastasis will be recorded weekly. The positivecontrol for the experiments is ADH-1 (Exherin), and the negative control is PBS in DMSO. Possible results: Thereare three main possible results: (1) MART-10 inhibits the growth and metastasis of PDAC cells; (2) MART-10 acts asa stimulant for PDAC growth and metastasis; (3) MART-10 has no significant effect on the growth and metastasis ofPDAC. Conclusion: The result of the study will provide important insight into the preclinical effectiveness of MART10 in PDAC; it also sets the basis for future clinical studies of the drug. Future studies should investigate the mechanismunderlying MART-10’s effectiveness in PDAC or search for drug combinations with MART-10 that synergize thedisease.
Iron ion and siramesine-loaded polydopamine nanoparticles forenhanced breast cancer therapy
Authors: Wang Yiming
Published: August 2023

Ferroptosis is a novel type of nonapoptotic cell death, showing a hopeful potential in cancer therapeutic schedules. Oneof the apparent features of ferroptosis is the lipid hydroperoxides producing ROS induced by intracellular iron ionsaccumulation. Thus the iron regulation and metabolism in the cell is an essential factors for the trigger of ferroptosis.We designed a new nanoparticle that loaded ferric ions and siamese based on polydopamine nanomaterial (siramesine@Fe(III) PDA NPs) to induce breast cancer ferroptosis through the Fenton reaction. Iron ions can be added to cancer cells,and siamese can block the exportation of intracellular iron by inhibiting the expression of FPN, thus promoting theFenton reaction. The extra transport of iron ions into cells by nanoparticles and the inhibition of iron ions outward bySiramesine promoted the accumulation of iron ions in cells, thus achieving a synergistic effect leading to ferroptosis incells. In addition, NPs demonstrated excellent pH-responsive degradation, with enhanced drug release at the pH valueof tumor microenvironments and lysosomal. Siramesine@Fe(III) PDA NPs showed good ferroptosis induction ability,displaying the potential for cancer treatment.
Shadow Education in China: An Analytical Discussion from a Supply and Demand Perspective
Authors: Kexuan Wang
Published: August 2023

Nowadays, private tutoring, also called shadow education, is received by students worldwide, and this behavior is particularly common in China. Students and tutors can satisfy their own needs simultaneously in this process. However, this practice also brings problems as the industry grows steadily. Previous scholars mainly focus on data results and policies to improve when researching this topic; nonetheless, the economic factors and effects are equally important. The current paper investigates the factors shaping the demand and supply of shadow education in China. Our finding suggests the demand of the public and suppliers’ willingness to provide an evolvable market environment for private tutoring. Some inefficiencies and financial problems are also discussed. Combining the technological change that shaped this industry, future studies could emphasize the supply side and the interaction within the shadow education market.
Introduction of Retrosynthetic Analysis and Guidelines Application of Analyze Molecules
Authors: Liu Haoyang , Zhu Jianing
Published: August 2023

Retrosynthesis is vital in breaking down complex target organic compounds based on known reactions. It serves as the reverse process of synthesis, which provides an alternative thinking path to aim for finding possibilities of synthesis reactions. In addition, different synthesis pathways can be discovered in the process of utilizing the retrosynthesis technology. It introduces the history of retrosynthetic synthesis using deoxygenation patterns which are different from disconnections, guidelines, and ordinary. In this work, a complete introduction to retrosynthesis and guidelines for people to apply retrosynthesis are well supported and introduced. The purpose of this paper is to serve as a detailed tutorial and offers specific rules for readers to learn.
Research on environmental management of domestic wasteincineration fly ash and high salt water discharge into the sea
Authors: Liu Haibing , Jiao Shaojun , He Yi
Published: August 2023

In our comprehensive management proposal for fly ash washing wastewater discharge into the sea, we establishstringent control measures across four categories: general elements, nutrients, heavy metals, and organic pollutants. Ourapproach is rooted in respect for and compliance with national and international pollution control standards. We definethe acceptable parameters for pH, salinity, and the content of Chemical Oxygen Demand (COD), suspended solids, totalnitrogen, ammonia nitrogen, phosphates, various heavy metals, and organic pollutants. Our plan includes thoroughlytreating wastewater, emphasizing the removal of lead, desalination, effective precipitation, and filtering processes beforethe wastewater is discharged into the sea. We advocate for constant surveillance and stringent management practicesto maintain a healthy marine ecosystem. Moreover, we acknowledge the need for additional biological testing in actualwork to more scientifically and comprehensively understand the potential impact of the discharged wastewater onmarine ecology. Our overall goal is to ensure that the potential environmental effects of fly ash washing wastewater areminimized while adhering to the highest environmental management standards.
Recent progress in Cetuximab-based treatment for Triple-NegativeBreast Cancer
Authors: Fengqianrui Chen
Published: August 2023

This study verifies the preclinical therapeutic effect of YM-1 silencing BAG3 combined with cetuximab targeted atepidermal growth factor receptor (EGFR) on Triple-Negative Breast Cancer (TNBC ) cell lines both in vitro and invivo. TNBC is defined as a unique subtype of breast cancer that leads to an increase in patients with interval cancerswhich can be detected annually. In actual research, targeted molecular therapies are involved in the field because of theimmunological heterogeneity of TNBC. YM-1 has a potentially better inhibition target for EGFR instead of BAG3. Byreviewing some existing preclinical research and targeted treatment for TNBC, this study is to propose a novel treatmenttarget for TNBC based on cetuximab treatment.
Maximizing Resource Utilization in GKE: A Case Study on IP AddressManagement and Budget Allocation in Google Kubernetes EngineConfig Page
Authors: Ou Yining
Published: August 2023

Maximizing resource utilization in Google Kubernetes Engine (GKE) can lead to cost savings and better performance.This case study examines how an organization optimizes IP address management and budget allocation in GKE bycombining static and dynamic IP addresses, reserved instances, and autoscaling. The organization found that static IPaddresses were useful for critical services, while dynamic IP addresses were more appropriate for non-critical services.Using reserved instances and autoscaling allowed the organization to minimize costs while ensuring that resourceswere available when needed. The findings of this study have implications for organizations using GKE, highlighting theimportance of effective resource utilization for achieving optimal performance and cost savings.
USO DE SISTEMAS NANOESTRUTURADOS NO TRATAMENTO DO CÂNCER
Authors: Geraldo Jony Marques , Montaño Valencia Carlos Julio
Published: August 2023

Intensa pesquisa foi deslocada para integrar a nanotecnologia no tratamento do câncer, face aos resultados insatisfatórios das abordagens terapêuticas tradicionais. A nanomedicina, campo sobreposto da nanotecnologia e da medicina, traz uma série de vantagens sobre a terapêutica convencional do câncer, incluindo radiosensibilização, multifuncionalidade, eficiência na entrega de drogas e liberação controlada de agentes quimioterápicos. Dentre as várias frentes de ação que têm sido seguidas, também a terapia gênica surge como uma proposta promissora como suporte ao tratamento do câncer, podendo ainda se aliar a sistemas nanoestrutrados para trazer um efeito sinergético, proporcionando bloqueio de marcadores metastáticos para aumentar a expectativa de vida em pacientes com estadiamento mais avançados.
INSTRUMENTOS PARA AVALIAÇÃO DE DOR PÓS OPERATÓRIA EM PACIENTES ONCOLÓGICOS:
Authors: Oliveira Célia Maria de , Dressler Natália Ramos de Menezes , Santos Wagner Jorge dos , Matos Selme Silqueira de
Published: August 2023

Enquanto doença crônica, o câncer está relacionado diretamente à dor e seu controle tem sido investigado. Esse trabalho apresentará discussão sobre como a dor em pacientes oncológicos tem sido avaliada. O objetivo foi analisar os principais métodos e/ou instrumentos utilizados para avaliação de dor em pacientes oncológicos no pós-operatório descritos na literatura científica. Trata-se de estudo de revisão integrativa, realizada nas bases de dados CINAHL, Cochrane, PubMed via MedLine, LILACS via BVS e Embase. Como critérios de inclusão foram utilizados: artigos publicados nos anos de 2015 a 2020, escritos em português, inglês e espanhol e cujos textos estavam disponíveis gratuitamente e na íntegra. A amostra foi composta por 22 estudos desenvolvidos em diversos países. Foi observado que a maior parte dos estudos utilizou de escala unidimensional para avaliação da dor. Reitera-se a importância de levar em consideração o aspecto álgico e utilizar diferentes métodos de avaliação na tomada de decisão sobre a linha de cuidados com o paciente oncológico. Como considerações finais, ressalta-se que não há na literatura pesquisada, questionários ou escalas exclusivas para a avaliação da dor do paciente oncológico, devendo o profissional da saúde se valer então de instrumentos multidimensionais já existentes para uma avaliação mais completa e precisa. É de suma importância que os serviços de saúde tenham profissionais qualificados e capacitados para aplicar e interpretar instrumentos de avaliação de dor.
PREVENÇÃO E TRATAMENTO DE LESÕES CUTÂNEAS PROVOCADAS POR INFILTRAÇÃO E EXTRAVASAMENTO DE DROGAS
Authors: Oliveira Célia Maria de , Macedo Alice Cordeiro de , Azevedo Roberta Vasconcellos Menezes de , Borges Eline Lima
Published: August 2023

O extravasamento de drogas administradas por via intravenosa pode ocorrer em vários contextos clínicos, e está predominantemente associado a cateteres venosos periféricos. O objetivo foi identificar na literatura evidências científicas sobre prevenção e tratamento de lesões cutâneas provocadas por infiltração e extravasamentos de drogas quimioterápicas, buscando métodos que norteiam as condutas de enfermagem, no intuito de aperfeiçoar os cuidados assistenciais aos pacientes submetidos a punção venosa. Trata-se de estudo de revisão integrativa realizado no portal BVS, nas bases de dados PubMed, Lillacs, Medline e BDENF. Foram utilizados os seguintes critérios de inclusão: artigos publicados sem limite de datas, nos idiomas português, inglês e espanhol. A amostra foi composta por oito estudos desenvolvidos em diversos países. A intervenção em caso de extravasamento requer fundamentação teórica e prática atualizada, uma vez que medidas de segurança no processo de administração de agentes quimioterápicos devem ser conhecidas pelas equipes de enfermagem, sendo de sua responsabilidade. Neste sentido, é fundamental monitorar a qualidade da assistência, refletir sobre a prática clínica com base naquilo que é observado e reforçar a cultura de segurança do paciente. Como considerações finais, apesar de não existirem recomendações uniformes acerca da melhor estratégia a adotar no intuito de prevenir infiltração e extravasamento de drogas, o diagnóstico e tratamento adequados poderão prevenir sequelas a longo-prazo.
The place of ecology in agricultural development projects
Authors: Bogolyubov Sergei Aleksandrovich
Published: August 2023

The adoption of numerous agricultural development projects presupposes their assessment from the point of view of regulating its interaction with the natural environment. In the projects, the legislator's ideas and ideas about the combination of objective laws of nature and legal laws are visible, the importance of natural resources for the development of the agro-industrial complex is reflected, and the proper natural environment is perceived as a condition for further development of agriculture, and not as an object of protection. In general, preference is given to the impact of the natural environment on agriculture, rather than agriculture on the environment. Agricultural projects differ from environmental legislation aimed at ensuring environmental protection by the agro-industrial complex. In projects, as well as acts on the development of agriculture, priority is given to protecting the agro-industrial complex from the negative effects of the forces of nature, their use in the interests of improving food well-being, and not protecting the environment from pollution during agricultural production, although it becomes one of the most important pollutants of nature. Such a bias should be gradually corrected and agricultural development projects should include not only its dependence on nature, measures to overcome it, but also ways of conducting such agricultural production that will negatively affect the quality of the environment to a minimum.
Involvement of the population of the USSR in providing assistance to families with children during the Great Patriotic War (on the example of the Baikal region)
Authors: Burdina Daria Aleksandrovna
Published: August 2023

The article discusses the issues of organizing assistance to Soviet families during the Great Patriotic War (1941-1945). In wartime conditions, accompanied by economic instability for the state, families with children, including military families, were in a difficult situation. Taking care of the Soviet family and the younger generation became the basis of the course of social policy, but the state could not always provide targeted assistance in time. That is why an important element of the organization of conditions for a stable situation of the population has become the involvement of collective farms, industrial and commercial enterprises, as well as individuals to assist families with children. The scientific novelty of the article consists in attracting a wide range of sources from the archives of the Republic of Buryatia and the Irkutsk region. Analysis of the documents showed that during the Great Patriotic War, the population helped those in need in various forms. In difficult times, the people acted unanimously and created various aid organizations: red Cross societies, charitable foundations, maternity and childhood committees. The population also helped those in need by accepting orphans, evacuated citizens and refugees for temporary residence. The enterprises did not stand aside. For the Baikal region, these measures were as important as for the rest of the USSR.
Legal Uncertainties in Interpretation of the Term ‘Consumer’ in the Legislation of European Union and the Practice of European Court
Authors: Bezborodov Alexander
Published: August 2023

The subject of the study is the harmonized norms of European legislation on consumer protection. In particular, the author is interested in the problems of interpretation of the concept of "consumer" in European law as a basis for understanding the essence of relations involving individual consumers. For the purposes of the study, the legislation of the European Union was chosen, as a legal system combining legal differences in the norms of different states, and perceiving and interpreting various legislative norms of the member states. The author analyzes both legislative norms and judicial practice in order to identify gaps in law enforcement and the practical applicability of the study. The author is interested in both the doctrinal component of the formation of the concept of "consumer" and the conclusions drawn in this regard by judicial practice. The author reveals the criteria formed in judicial practice for determining the activity of an individual as commercial, and also reveals the approach of the European legislator to the purpose of the consumer contract. In his research, the author uses methods of analysis and synthesis to clarify the essence of the concept of "consumer" used in various normative legal acts and judicial practice, as well as to form conclusions about the formation of the concept of "consumer" in European law. The main conclusions made in the course of the study are the conclusion about the criteria formed for the qualification of a person as a consumer and their possible components, and the approach is also defined, according to which the activity of an individual can have a dual character, depending on the purpose and substance of the contract that the consumer enters into.
HASHTAG AKTİVİZMİ ARAŞTIRMALARININ BIBLİYOMETRİK ANALİZİ
Authors: İLİ Burak , BÜYÜKBAYKAL Güven Necati
Published: August 2023

HASHTAG AKTİVİZMİ ARAŞTIRMALARIN BİBLİYOMETRİK ANALİZİ

ÖZ

Tarihsel olarak marjinalize edilen topluluklar ve seslerini duyuramayan bireyler için sosyal medya, önemli bir etkileşim ve farkındalık imkânı sunmaktadır. Sosyal medyanın yaygın kullanımı, hemen her alanda olduğu gibi toplumsal hareketlerin ve aktivizm faaliyetlerinin yeniden şekillenmesinde de önemli rol oynamaktadır. Bu kapsamda ortaya çıkan hashtag aktivizmi, sosyal medya ağlarında hashtaglerin kullanımıyla gerçekleşen bir dijital aktivizm hareketi olarak dikkat çekmektedir.

Bu araştırma, uluslararası bir veri tabanı olarak dünya çapında kullanılan Scopus’ta yayınlanmış hashtag aktivizmine yönelik çalışmaların bibliyometrik analiz ile incelenerek, günümüzdeki ve gelecekteki eğilimleri ortayı çıkarmayı amaçlamaktadır. Bu kapsamda, 5 Haziran 2023 tarihinde ‘‘hashtag activism’’ terimi kullanılarak Scopus’ta bir inceleme gerçekleştirilmiş ve araştırma başlıklarında bulunması şeklinde sınırlandırılarak toplamda 72 akademik çalışmaya ulaşılmıştır. Hashtag aktivizmine yönelik araştırmalar, VOSviewer yazılımı kullanılarak yazarlar, yayın yılları, anahtar kelimeler, atıflar, ülkeler ve ortak yazarlık gibi farklı çerçevelerde incelenerek tablolaştırılmış ve görselleştirilmiştir. Elde edilen bulgulara göre, henüz yeni sayılabilecek bir kavram olan hashtag aktivizmine yönelik araştırmaların Scopus veri tabanında 2015 yılı itibarıyla yayınlandıkları, toplamda 72 araştırmanın genellikle ülke bazında gerçekleştirildiği, en çok yayın yapan ve atıf alan ülkenin Amerika Birleşik Devletleri olduğu ve hashtag aktivizminin en çok sosyal medya, feminizm ve Twitter anahtar kelimeleri ile birlikte kullanıldığı gibi sonuçlara ulaşılmıştır.

Anahtar Kelimeler: Hashtag Aktivizmi, Sosyal Medya, Toplumsal Hareketler, Bibliyometrik Analiz, Scopus, VOSviewer
MULTİMODAL LOGO OLARAK GOOGLE DOODLES TASARIMLARINDA YAZAR VE ŞAİRLERİN BETİMLENMESİ
Authors: GÖNÜLLÜ Açelya B.
Published: August 2023

Çok uluslu bir Amerikan teknoloji şirketi ve dünya genelinde popüler bir internet arama motoru olan Google, 1998 yılında Burning Man Festivali'ni kutlamak üzere logosu üzerinde küçük bir değişiklik yaparak dinamik logo türünü uygulamaya başlamıştır. Multimodal bir yapı içinde kurgulanan bu dinamik logo, Google Doodles olarak adlandırılır. Doodles tasarımları her zaman yayınlanmamakta; önemli olaylar, keşifler veya kişileri kutlayan günlerde kullanılmaktadır. Böylece zaman faktörü, kullanıcıda merak ve beklenti duygusu yaratmaktadır. Bu çalışmada, 2009-2018 yılları arasında yayınlanmış olan, toplam sekiz yazar ve şairin doğum günlerini kutlayan doodle tasarımları incelenmiştir. Bu tasarımlarda, yazar ve şairlerin hangi tekniklerle ve nasıl betimlendiğini araştırmak amaçlanmıştır. Çalışmada veri toplama yöntemi olarak genel tarama modeli kullanılmış, doodle’lar teknik kiplerine göre sınıflandırılmış ve daha sonra göstergebilimsel yöntem ile içerik analizi yapılmıştır. Elde edilen bulgulara göre, yazar ve şairleri betimleme yöntemi olarak en çok eserden sahne ile iki boyutlu illüstrasyon tekniklerinin kullanıldığı görülmüştür. Eserden sahne tekniği kullanımının, yazar ve şairlerin popüler eserleri üzerinden gerçekleştirildiği sonucuna ulaşılmıştır. Bunun yanı sıra bu edebi eser betimlemelerinde, portre ve animasyon teknikleri kullanılmış olsa da bu tekniklerin diğerlerine kıyasla daha az tercih edildiği gözlemlenmiştir. Araştırmada yer verilen iki şair doodle tasarımında animasyon tekniğinin kullanılmış olması ise dikkat çekicidir. Bu tekniğin kullanılması sayesinde, şiir sanatının doğasına özgü zaman olgusunun başarılı bir şekilde yansıtılmış olduğu düşünülmektedir.

Anahtar Kelimeler: Dinamik logo, Google Doodles, Göstergebilim, İllüstrasyon, Logo tasarımı, Multimodal, Şair, Yazar.
YALNIZLIK, SOSYAL MEDYA VE SANAL YAŞAMIN BİREYLER ÜZERİNDEKİ ETKİSİ: SANAL HAYATLAR FİLMİ ÖRNEĞİ
Authors: ERGÜN Zuhal , MISIRLI Gülsemin
Published: August 2023

Sosyal yaşamda kurulan ilişkiler internetin gelişmesiyle birlikte dijital yaşama taşınmış ve bu mecralarda sürdürülmeye başlamıştır. Günümüzde insanların yalnızlığını sosyal ağlarda kurdukları ilişkilerle gidermeye çalıştıkları düşünülmektedir. Ancak diğer taraftan bu mecralarda çok fazla vakit geçirdikleri için yalnızlığa mahkûm oldukları da bilinmektedir. Dolayısıyla bu iki durum kısır bir döngü olarak karşımıza çıkmaktadır. Günümüzde bireyler sosyal medyada uzun süre geçirmekte, gerçek hayatta kurması gereken ilişkilerini bu mecralarda kurmaktadırlar. Bu durum adeta çağın vebası sayılan iletişimsizlik sorununu ortaya çıkarmakta ve bireyler çözümü sosyal mecralarda aramaya başlamaktadır. Oysa internet, yalnızlık ve gerçek hayattaki iletişimsizliğe çözümmüş gibi görünse de kendi çıkmazı ile beraber insanların yaşamlarına dahil olmuştur. Böylece hayatın her alanına yerleşen sosyal ağlarda birçok kişi, sanal mecralarda yaşadıkları sorunlarla gerçek hayatta yüzleşmek durumunda kalmıştır. Çünkü sanal yaşamda sürdürülen hayatlar ile sosyal yaşam birbirinden kopuk değildir. Hatta bunlar birbiri ile etkileşim içerisindedirler. Sanal yaşamda kurulan iletişim sonucu ortaya çıkan bir sorun gerçek yaşamı da etkileyebilmektedir. Bu çalışmanın amacı sosyal ağların insanların yalnızlığına çare gibi sunulmasını ve iletişim ihtiyaçlarını karşılayan bir alan gibi görülmesini anlatan Sanal Hayatlar (Disconnect) filmini incelemektir. Çalışma kapsamında, filmde yalnızlığını sosyal ağlarda gidermeye çalışan kişilerin bu ağları bilinçsiz kullandıklarında gerçek yaşamlarında ne kadar büyük tehlikelerle karşılaştıkları sorunsalı betimsel içerik analizi yönteminden faydalanarak ortaya konulmuştur. Çalışma, yalnızlık ve sosyal medya ilişkisini film karakterleri üzerinden inceleyip değerlendirmesi bakımından önemlidir.
Detection of defects in bulging processes by means of dynamic laser speckle
Authors: Jasiński Cezary , Morawiński Łukasz , Kocańda Andrzej
Published: August 2023

The method described in this paper has been used to determine the moment when defects appear in the form of strain localization and grooves in the Marciniak bulging tests. In this method based on dynamic laser speckle, the sheet is illuminated by laser. Interference after reflection from the specimen surface creates a characteristic image of bright and dark spots. Specimen surface changes related with deformations and movements cause changes in the shape and size of spots, which are presented by authors in the form of speckle activity image. In order to identify the type of defect, the additional 3D microscopy measurements were performed. This paper presents analysis of the changes in the speckle activity image during the bulging process which enabled the defects identification during the bulging process.
Numerical determination of equiaxed grain radii arising in the casting during 3D simulation of solidification
Authors: Dyja Robert , Gawrońska Elżbieta , Grosser Andrzej , Jeruszka Piotr , Sczygiol Norbert
Published: August 2023

The knowledge of material structure allows to predict the mechanical properties of alloy casting. Such structure can be modelled in micro- and mesoscale. The first way is connected with alloy morphology and enables one to find out the shape of grains emerging during the solidification process. The second way allows to define the magnitude and distribution of these grains in the casting structure. Learning both of these ways greatly enhances one’s knowledge about such mechanical phenomena as emerging stresses, strains, hot cracking and many others. This information makes it possible for one to predict the behaviour of castings during the cooling process or the further product exploitation. The one of the most difficult issues in the numerical and computer simulations of solidification is the modelling of the structure evolving in the casting. These simulations are extremely important in the work of an engineer in the foundry industry. The paper deals with a numerical modelling of equiaxed microstructure formation during the solidification of two-component alloys. The basic enthalpy formulation was applied to model the solidification. The equiaxed grain size depends on the average cooling velocity at the moment when the liquid metal reaches the liquidus temperature. The experimentally determined dependence between grain radius and cooling velocity was used in the calculation of average grain radii distribution.
Elaboration of ductile fracture criteria based on punching forgeability test
Authors: Lisiecki Łukasz , Skubisz Piotr
Published: August 2023

A new approach of forgeability test, based on compression-punching state of stress was proposed. Comparison of the results of the presented research methodology with standard compression test is presented. The new forgeability test is designed to generate controllable failure location for good plasticity materials, which high the level of stresses accompanying the fracture. Different shape of tools and specimens tend to show the effect of geometry on the areas of concentrations of tensile and shear stresses, which play important role in formation of cracks. The paper presents the methodology based on laboratory tests of compression and pseudo-punching performed on laboratory rig with 5MN hydraulic press and numerical FEM simulation of the tests on commercial code with introduction of the elaborated fracture criteria.
Modelling of transient temperature field and phase transformation change a way for residual stress management in large size forgings
Authors: Sroka Jakub , Talamantes-Silva Jesus  , Krzyzanowski Michal  , Rainforth Mark 
Published: August 2023

The paper is devoted to development of the modelling approach based on 3D finite-element (FE) analysis of the transient temperature fields and the thermally induced phase transformations as a way towards residual stress management in large size forgings. Heating, holding and cooling stages are under consideration and modelling of both the austenite formation and decomposition are taken into account. The thermal-mechanical FE model capable of taking into account changes in the specific volume during ferrite/austenite transformation is coupled with the relevant phase transformation model in order to allow simulation of the transient stresses due to both thermal contraction and the dilatometric effect. The model is capable of taking into account different boundary conditions for the heat transfer problem based on the available data. To improve the predictive abilities, the following two commercial FE codes, such as MSC Marc 2013.1.0 and Abaqus/Standard6.12, are used for solving the non-steady state 3D problem of the metal expansion/contraction during consecutive heating, holding and cooling stages. Although all the mentioned process steps are considered, the model is dedicated to be used for modelling the cooling stages of large forgings and castings.
Parallel computing of metal forming simulation in QForm software
Authors: Gerasimov Dmitry , Gartvig Arthur
Published: August 2023

In this study, the principle of parallelization of data and tasks implemented in QForm software is described. The dependence of the number of simultaneously working logical processors or cores of a multi-core CPU on the solving time of metal forming simulation is investigated.
Using the System of Graph Grammar for generation of quasi optimal element partition trees in two dimensions
Authors: Paszyńska Anna  , Świderska Iwona  , Woźniak Maciej  , Jopek Konrad  , Paszyński Maciej  , Grabska Ewa  , Lenhart Andrew  , Nguyen Donals  , Pingali Keshav 
Published: August 2023

The paper presents a graph grammar based approach for h-adaptive finite element method and multi-frontal solver algorithm. The multi-frontal solver is used for solving systems of linear equations created by finite element method. The multi-frontal solver is controlled by so-called ordering. The quality of ordering influences hardly the solver effectiveness. In our approach, the finite element mesh is represented by means of a hypergraph and corresponding element partition tree. The finite element operations like mesh generation or h-adaptation are modelled by graph grammar production. Additionally graph grammar productions have corresponding productions for the construction of the element partition tree. The element partition trees are transformed into the ordering that controlls execution of the solver algorithm. We show that the ordering resulting from our element partititon tree results in better performance of the parallel solver than the state of the art nested-dissection ordering available through MUMPS interface on the class of grids refined towards singularities.
A parallelized model for coupled phase field and crystal plasticity simulation
Authors: Lin Mingxuan  , Prahl Ulrich 
Published: August 2023

The predictive simulation of materials with strong interaction between microstructural evolution and mechanical deformation requires the coupling of two or more multi-physics models. The coupling between phase-field method and various mechanical models have drawn growing interests. Here, we propose a coupled multi-phase-field and crystal plasticity model that respects the anisotropic mechanical behavior of crystalline materials. The difference of computational complexity and solver requirements between these models presents a challenging problem for coupling and parallelization. The proposed method enables parallel computation of both models using different numerical solvers with different time discretization.  Finally two demonstrative examples are given with an application to the austenite-ferrite transformation in iron-based alloys.
Sensitivity analysis and identification of the phase transformation model based on the control theory
Authors: Milenin Ivan , Bzowski Krzysztof , Rauch Łukasz
Published: August 2023

The aim of this work was to improve the previously developed model of austenite-ferrite phase transformation by its identification for selected steels and by performing sensitivity analysis. Created model allows prediction of phase transformation kinetics for non-isothermal conditions. Model is characterized by very short computing time and relatively good predictive capabilities. There are five input coefficients in the model, which should be identified for each steel on the basis of dilatometric tests. In the previous works model was used to predict phase transformation kinetics in various DP steels for different thermal cycles. In the first part of this work sensitivity analysis of the model was performed using three methods: quality method, factorial design method and Morris analysis method. Obtained sensitivity coefficients described how changes of the model input parameters influence the response of the model and which of these parameters are the most significant. The second part of the work was devoted to model identification for the selected steels. Identification problem was turned into optimization task which was solved using Hooke-Jeeves method. Obtained model’s parameters allowed describing austenite-ferrite phase transformation in the conditions of varying temperatures. Validation of the model was performed by comparison with the results obtained from the advances numerical model based on the solution of the diffusion equation in the austenite. Results obtain from both models for typical thermal cycled used to obtain multiphase microstructure were compared.
Strategy for the selection of the best phase transformation model for simulation of metals processing
Authors: Rauch Łukasz , Bzowski Krzysztof , Perzyński Konrad , Madej Łukasz , Milenin Andriy , Pietrzyk Maciej
Published: August 2023

Connection of the finite element program with phase transformation models is often needed when prediction of distribution of phase composition in the product is of interest. Depending on the type of the phase transformation model this connection may involve long computing times. Moreover, when the optimization task has to be formulated and solved, the computing costs may radically increase. It is particularly troublesome when the objective function is composed of advanced microstructural parameters or product properties, evaluation of which requires an application of multiscale modelling techniques. In the present paper the possibilities of decreasing of the computing costs for optimization of metals processing were explored. Several case studies, which require connection of the FE code with phase transformation models, were analysed and computing times were compared. Efficiency of modelling depending on the complexity of the macro scale FE mesh was evaluated
Numerical model of thin metal film heating using the boundary element method
Authors: Majchrzak Ewa  , Mochnacki Bohdan 
Published: August 2023

The subject of the paper is connected with the microscale heat transfer proceeding in the metal domain. In particular, the heating process of thin metal film subjected to an external heat flux is analysed. Thermal processes in the domain considered  are described by the dual-phase lag equation (DPLE) supplemented by the appropriate boundary and initial conditions. At the stage of numerical modeling the variant of the boundary element method called the BEM using discretization in time is applied. So far, this method has not been used fo the hyperbolic equations describing the microscale heat transfer. In the final part the example of computations is shown.
External force field during diffusion - sedimentation in condensed matter
Authors: Wierzba Bartek , Nowak Wojciech , Wierzba Patrycja , Sieniawski Jan
Published: August 2023

In this paper numerical description of the external force field during interdiffusion is discussed. Two methods of modeling the sedimentation process will be presented. Mainly, the steady state and evolutionary approximation. The proposed approaches will based on the generalized Darken method. The main equations will be the mass conservation and equation of Both presented approximations will based on the method of lines to solve numerically the ordinary differential equations (ODEs) system resulting from the space discretization (Schiesser, 1991). The uniform grid, which contained N mesh points along the x direction, respectively, was used and the concentrations and drift velocity were defined at points xk. The applied discretization led to the system of ODEs in time variable. The evolutionary method will based additionally on the adaptive step-size Runge–Kutta-Fehlberg modification. The six evaluations of the functions from the fifth-order Runge–Kutta algorithm were used to make other combinations implemented in the fourth-order Runge–Kutta method. The difference between these two estimates served as an estimate of the truncation error. Hence, the step size was adjusted (Press, 1992). The results of the proposed methods will be compared and discussed.motion. Thus the simultaneous action of backstress, external forces and of Kirkendall shift during interdiffusion in metals is described by self-consistent scheme. The diffusion flux is than determined by both, chemical and mechanical potentials - j=Di grad(ui).
Towards intelligent materials testing with reduced experimental effort for hot forming
Authors: Bambach Markus , Imran Muhammad  , Buhl Johannes  , Härtel Sebastian  , Awiszus Birgit 
Published: August 2023

Hot forming processes are typically used to deform metals to the desired shape at lower forming forces and to control the microstructure. During hot deformation, the microstructure evolves by dynamic recrystallization after certain critical conditions are reached. The final recrystallized grain size controls the post-hot forming mechanical properties of metals and components. To predict the evolution of microstructure and flow stress, various material models were developed and implemented in finite element codes. They require a significant number of material-dependent parameters. Currently, experimental designs with a full-factorial approach for a range of temperature and strain rates are utilized to determine the desired parameters, which involve a huge experimental effort. The aim of this paper is to propose a methodology for parameter identification with reduced experimental effort where progression of testing and data evaluation is parallelized. An iterative, sequential approach is presented which optimizes the new testing conditions based upon preceding experimental conditions. The approach is exemplified for the high-temperature material Alloy-800H, using a material model that allows for accurate predictions of the flow stress. The developed strategy allows to achieve the desired accuracy of the material model by utilizing about a half of test matrix representing a full-factorial design. Hence, an efficient cost- and resource-optimized
Finite Element Modelling of Titanium Aluminides
Authors: Sizova Irina  , Sviridov Alexander  , Günther Martin  , Bambach Markus 
Published: August 2023

Hot forging is an important process for shaping and property control of lightweight titanium aluminide parts. Dynamic recrystallization and phase transformations play an essential role for the resulting grain size and accordingly the mechanical properties. Due to the fact that titanium aluminides require forging under isothermal conditions, reliable process modeling is needed to predict the microstructure evolution, to optimize the process time and to avoid excessive die loads. In the present study an isothermal forging process of a compressor blade made of TNB-V4 (Ti–44.5Al–6.25Nb–0.8Mo–0.1B, at. %) is modeled using the Finite Element (FE) – Software Q-Form. A microstructure model describing the microstructure evolution during forging is presented. To calibrate the model, the high-temperature deformation behavior was investigated using isothermal compression tests. The tests were carried out at temperatures from 1150°C to 1300°C, applying strain rates ranging from 0.001s-1 to 0.5s-1, up to a true strain of 0.9. The experimentally determined flow stress data were described with model equations determined form the course of the strain hardening rate in Kocks-Mecking plots. An isothermal forging process of a compressor blade was carried out and used to validate the results from the FE simulations.
The MLPG in gradient theory for size-dependent magnetoelectroelasticity
Authors: Sladek Jan , Sladek Vladimir , Hrcek Slavomir
Published: August 2023

The strain gradient magnetoelectroelasticity is applied to solve two-dimensional boundary value problems. The electric and magnetic field-strain gradient coupling is considered in constitutive equations. The meshless local Petrov-Galerkin (MLPG) is developed to solve general problems. All field quantities are approximated by the moving least-squares (MLS) scheme. Effective material properties for a piezomagnetic matrix with regularly distributed piezoelectric fibres of a circular cross section and coating layer are presented.
Efficient Transfer of C++ Objects on Intel Xeon Phi KNC in Offload Mode
Authors: Hanousek Vít , Oberhuber Tomáš
Published: August 2023

Intel Xeon Phi KNC is a modern coprocessor designed for the high performance computing. In this paper we describe efficient method for transferring C++ objects in the Offloading mode. Our aim is to get consistent interface with NVidia CUDA framework in Template Numerical Library (TNL). As working example we use this library and the heat equation problem to demonstrate efficiency of implementation on Intel Xeon Phi and compare CPU with this coprocessor.
Traveling pulse solutions in a point mass model of diffusing particles
Authors: Ginder Elliott , Minomo Takaaki , Nagayama Masaharu , Nakata Satoshi , Yamamoto Hiroya
Published: August 2023

We study a partial differential equation modeling the self-motion of camphor particles atop a water surface. The model equation is presented in the form of a reaction-diffusion system where source terms are expressed by delta functions. The resulting system is a point mass model for diffusing particles, where the role of the delta functions is to express camphor source locations. In our model, point sources interact with each other and move by the gradient of the concentration field. We will discuss analytical properties of the model equation. In particular, we will study properties of traveling pulse solutions, whose existence are reduced to the solution of an ordinary differential equation, coupled with a boundary value problem. The existence and stability of solutions will be shown and we will compare our findings with those which have utilized characteristic function source terms.
Structure-preserving numerical scheme for a generalized area-preserving crystalline curvature flow
Authors: Ishiwata Tetsuya , Yazaki Shigetoshi
Published: August 2023

The presented numerical scheme preserves variational structure of a generalized area-preserving crystalline curvature flow.   The scheme is based on an iteration and a projection method. Several numerical examples will verify that the enclosed area is preserved in numerical computation with high accuracy in the sense of double precision. Numerical computations realize theoretical convexification results starting from almost convex polygon, and are extended to a general setting starting from nonconvex polygon.