bluuebunny/crossref_metadata_2025 huggingface dataset:
RAG for Personalized Medicine: A Framework for Integrating Patient Data and Pharmaceutical Knowledge for Treatment Recommendations
Authors: Zhang Zhaoyan
Published: February 2025

Personalized medicine aims to tailor treatment strategies to individual patients by integrating diverse medical data and pharmaceutical knowledge. To address challenges such as data heterogeneity, knowledge retrieval, and safety evaluation, this paper proposes a novel framework utilizing a dynamic Retrieval-Augmented Generation (RAG). The framework integrates multi-modal patient data, including electronic health records (EHRs) and genomic information, with pharmaceutical knowledge bases such as DrugBank and PubMed.  A dynamic retrieval mechanism is designed to extract relevant knowledge in real-time, while contextual filtering ensures recommendations are both accurate and clinically safe. Through extensive experiments on simulated patient scenarios, the proposed framework demonstrates significant improvements in recommendation precision, relevance, and safety compared to baseline methods.  Results show that the approach provides a reliable and interpretable system for personalized drug recommendations, offering new perspectives for advancing decision support in personalized medicine.
Discerning the Identity and Ostracization: The Phase of Subservience in A.Revathi's "The Truth About Me"
Authors: Dhariga. J  , Dr.Alby Grace
Published: February 2025

This research article explores the complex relationship between marginalization and gender identity. The novel amplifies the voices of the transgender community in India. It raises questions about the institutional, societal, and cultural practices that perpetuate their marginalization and examines how Revathi’s novel highlights the connection between gender identity and the subservient experience of transgender individuals. Drawing on Trauma Theory, this article, through its lens, examines the struggles endured by transgender people, which lead to particular forms of discrimination and social exclusion. Through Revathi’s narration, this article addresses the existential crisis that accompanies identity formation in the context of marginalization, shaped by social class, caste, and gender. This study aims to provide a crucial framework for exploring how the voices of marginalized people navigate a society that often attempts to silence them. It also offers insight into how Revathi’s life experiences deepen the understanding of the complexity of gender identity.
Metode Ijmali dan Aplikasinya dalam Penafsiran Al-Qur'an
Authors: Selian Bagas Nirwana , Syabuddin Syabuddin
Published: February 2025

Metode ijmali merupakan salah satu pendekatan penting dalam penafsiran Al-Qur'an yang menekankan pada kejelasan dan kesederhanaan dalam menyampaikan makna ayat-ayat suci. Penelitian ini bertujuan untuk mengeksplorasi karakteristik, kelebihan, dan kekurangan dari metode ijmāli serta aplikasinya dalam konteks penafsiran Al-Qur'an. Dengan menggunakan pendekatan kualitatif dan jenis penelitian pustaka, data dikumpulkan melalui kajian literatur yang relevan, baik dari sumber cetak maupun elektronik. Hasil penelitian menunjukkan bahwa metode ijmāli, yang pertama kali diterapkan oleh Nabi Muhammad SAW, memiliki kemampuan untuk menyampaikan pesan-pesan Al-Qur'an secara ringkas dan global, sehingga mudah dipahami oleh umat Islam. Metode ini juga memiliki langkah-langkah yang sistematis, yang meliputi penguraian ayat-ayat Al-Qur'an dan penjelasan makna mufradat sesuai kaidah bahasa Arab, termasuk analisis gramatikal serta pemilihan diksi yang mencerminkan lafaz Al-Qur'an Meskipun metode ini memiliki kelebihan dalam hal kejelasan dan kebebasan dari pengaruh penafsiran Israiliyat, terdapat juga kelemahan yang perlu diperhatikan, seperti petunjuk yang tidak utuh dan potensi penafsiran yang dangkal. Penelitian ini diharapkan dapat memberikan kontribusi dalam memahami metode ijmāli dan meningkatkan cara penafsiran Al-Qur'an yang lebih efektif dan aplikatif.
Eksistensi Asbabun Nuzul Dalam Penafsiran Al-Quran di Era Modern
Authors: Mariati Mariati
Published: February 2025

Asbabun Nuzul merujuk pada kejadia-kejadian atau alasan yang menjadi factor utama turunnya satu ayat atau sekumpulan ayat yang ada dalam Al-Quran. Konsep asbabun nuzul tersebut memiliki peranan yang paling penting dalam memahami tafsir Al-Quran, terutama bagi para mufassir di era modern ini. Asbabun Nuzul memberikan konteks sejarah yang esensial dalam menjelaskan turunnya ayat-ayat tertentu dan membantu para mufassir dalam menginterpretasikan makna-makna yang tersirat. Penelitian ini memanfaatkan metode kajian pustaka dengan mengumpulkan berbagai referensi, seperti buku-buku dan artikel/jurnal yang terkait dengan topik pembahsan yaitu eksistensi asbabun nuzul. Hasil penelitian menunjukkan bahwa interpretasi tentang asbabun nuzul sangat membantu para mufassir dalam mengetahui konteks turunnya ayat, dan dapat mengurangi kemungkinan kesalahan atau  keraguan dalam penafsiran Al-Quran. Oleh karena itu, sangat penting bagi para mufassir modern untuk memperhatikan riwayat asbabun nuzul, agar tidak terjadi kekeliruan dalam tafsir dan untuk memahami hikmah di balik turunnya ayat tersebut
Obyek 'Akal Bagi Kehidupan Manusia: Prespektif Al-Qur’an
Authors: Nada Alfaini Zulfa , Soleh Achmad Khudori
Published: February 2025

Akal adalah kemampuan berpikir yang memungkinkan seseorang memahami sesuatu. Namun, akal memiliki batasan karena ada ajaran yang tidak bisa dipahami dengan akal. Dalam Al-Qur'an, Penelitian ini bertujuan untuk menggali dan menganalisis peranan akal dalam kehidupan manusia berdasarkan perspektif Al-Quran. Menggunakan metode penelitian kepustakaan yang meliputi pengumpulan sumber-sumber bibliografi yang relevan dengan fokus penelitian, teknik pengumpulan data dari sumber kitab tafsir al misbah kemudian ada buku, jurnal, artikel dan perpustakaan. Dari hasil penelitian ini terdapat: 1). berbagai ayat Al-Quran istilah 'aql muncul sebanyak 49 kali dengan berbentuk fi'il mudhari'. Di antara bentuk-bentuk tersebut, kata ta’qilun muncul sebanyak 24 kali dan ya’qilun sebanyak 22 kali. Sedangkan verba lain seperti 'aqala, na'qilu, dan ya'qilu masing-masing hanya muncul satu kali. 2). Akal dalam Al-Qur'an memiliki peran penting untuk memahami ciptaan Allah. Manusia diajak untuk merenung dan berpikir tentang fenomena alam seperti langit, bumi, pergantian siang dan malam, laut, hujan dan binatang yang semuanya merupakan tanda-tanda kebesaran Allah. 3). Al-Qur'an menekankan pentingnya akal bagi manusia, yaitu: Akal untuk memahami kebenaran dan mendorong berpikir, akal juga sebagai objek kajian untuk mempelajari alam sebagai tanda kekuasaan Tuhan. Selain itu, al-Qur'an menegur mereka yang tidak menggunakan akal dan ingkar terhadap kebenaran.
Implementasi Pembelajaran Akidah Akhlak Dalam Meningkatkan Perilaku Siswa
Authors: Sari Deviana
Published: February 2025

Jurnal ini membahas bagaimana pendidikan akidah akhlak diterapkan di lingkungan sekolah untuk meningkatkan perilaku siswa. Berbagai metode yang digunakan dalam implementasi pendidikan ini, seperti ceramah, diskusi, kegiatan ekstrakurikuler, serta pembiasaan sehari-hari di sekolah, dibahas secara mendalam. Setiap metode memiliki tujuan untuk menanamkan nilai-nilai positif, seperti disiplin, kejujuran, empati, rasa hormat, dan kepedulian terhadap sesama. Selain itu, artikel ini juga mengidentifikasi berbagai tantangan yang dihadapi dalam proses implementasi, seperti keterbatasan sumber daya, pengaruh negatif dari lingkungan sosial, serta perbedaan latar belakang keluarga siswa. Walaupun demikian, penelitian ini menegaskan bahwa dengan penerapan yang konsisten dan kolaborasi antara pihak sekolah dan orang tua, pendidikan akidah akhlak dapat efektif dalam membentuk perilaku siswa yang lebih baik dan mempersiapkan mereka untuk menjadi individu yang bertanggung jawab dalam masyarakat.
Pengaruh Penerapan Observasi dan Konseling Ringan Terhadap Kepuasan Kerja di PT. Lion Super Indo Basilica
Authors: Rina Octaviana  , Alfina Damayanti
Published: February 2025

This Field Work Practice (PKL) Report documents the implementation of a light counseling program that was observed at PT Lion Super Indo Basilica, Palembang. This program was designed to address various operational problems that affect employee job satisfaction. SWOT analysis was used as an analysis method to evaluate the program's strengths, weaknesses, opportunities, and threats. The results showed significant changes in several aspects of performance. Communication between teams became more effective, accuracy in work increased, and store operational efficiency improved. Several employees reported that the counseling sessions helped them understand their respective roles and responsibilities, and encouraged work motivation. However, the implementation of the program faced several limitations, such as the limited number of participants (10-20 employees) due to lack of human resources and short implementation time.
Real Time Signal Decoding in Closed Loop Brain Computer Interface for Cognitive Modulation
Authors: Khan Naimat Ullah , Raza ur Rehman Hafiz Muhammad
Published: February 2025

This research presents a novel closed-loop Brain-Computer Interface (BCI) system designed to enhance cognitive performance through targeted neurofeedback. The study addresses the critical challenge of decoding and modulating higher-order cognitive states such as attention, memory, and decision-making, which are often hindered by inter-subject variability and limited datasets. By integrating EEG-based signal acquisition, advanced preprocessing, feature extraction using spatial and temporal analysis, and deep learning models such as CNNs, LSTMs, and Transformers, the system achieves robust and real-time classification of cognitive states. Neurofeedback mechanisms are adapted in real-time to align with user-specific neural profiles, promoting progressive cognitive improvement. Experiments involving participants aged 18 to 50 years demonstrated a classification accuracy exceeding 92% with significant task performance gains of 18% in attention and 22% in memory retention. The findings reveal the system's efficacy in decoding complex neural patterns while maintaining adaptability across diverse populations. This work contributes to the body of knowledge by providing a scalable framework for practical cognitive enhancement applications, bridging gaps between neuroscience, machine learning, and signal processing. Future research may extend the system's capabilities to multi-modal data integration and investigate long-term neuroplasticity effects, paving the way for broader applications in education, healthcare, and human-machine interaction.
Examination of school counselors’ professional competencies within the framework of national occupational standards
Authors: İvecen Erdem , Sezer Fahri
Published: February 2025

In this study, the professional competency levels of school counselors were evaluated within the framework of the National Occupational Standards (NOS). A total of 204 school counselors working in public and private schools under the Ministry of National Education were included in the study using simple random sampling. The research employed quantitative methods, including a descriptive survey model and qualitative analysis; participants were administered a personal information form and a NOS criteria scale. The data were analyzed using SPSS 22.0. No significant differences were found in the NOS criteria based on gender and type of institution. However, significant differences were identified in terms of the field of study and years of service. It was found that the professional competency levels of those with a master’s degree were higher compared to those with a bachelor’s degree. The research findings revealed that school counselors had low professional competency levels in areas such as the development and evaluation of guidance and counseling programs, the provision of intervention services, and the implementation of developmental activities. Additionally, it was observed that post-graduate education had a positive effect on enhancing professional competencies.
Pelaksanaan Projek Penguatan Profil Pelajar Pancasila (P5) terhadap Pembentukan Sikap Demokrasi dan Bertanggung Jawab Sosial Pada Siswa Kelas XI B SMA Negeri 5 Pontianak
Authors: Pitaloka Whilis Putri
Published: February 2025

Pelaksanakan penelitian ini bertujuan untuk mengukur pengaruh pelaksanaan Projek Penguatan Profil Pelajar Pancasila (P5) terhadap pembentukan sikap demokrasi dan bertanggung jawab sosial pada siswa kelas XI B SMA Negeri 5 Pontianak. Menumbuhkan sikap demokrasi dan bertanggung jawab sosial dirasa sangat penting diterapkan pada generasi muda saat ini. Hal ini menjadi perhatian khusus pemerintah dan dunia Pendidikan dalam memberikan wadah juga solusi pembentukan karakter penerus bangsa. Salah satunya dengan pelaksanaan Projek Penguatan Profil Pelajar Pancasila (P5) program yang dirancang Kemendikbudristek sebagai bagian dari Kurikulum Merdeka yang bertujuan untuk mendorong tercapainya Profil Pelajar Pancasila. Penelitian ini menggunakan pendekatan deskriptif kuantitatif dengan metode survei. Data dikumpulkan melalui kuesioner yang diisi oleh siswa dan dianalisis menggunakan analisis regresi linier sederhana. Hasil penelitian menunjukkan bahwa pelaksanaan P5 memiliki pengaruh positif dan signifikan terhadap pembentukan sikap demokrasi dan bertanggung jawab sosial. Temuan ini menunjukkan pentingnya pelaksanaan P5 dalam mendukung penmbentukan karakter siswa sesuai dengan nilai-nilai Pancasila khususnya terhadap sikap demokrasi dan bertanggung jawab sosial.
Implementasi Model Pembelajaran Problem Based Learning pada Mata Pelajaran PAI Kelas XI di SMA Plus Citra Madinatul Ilmi Banjarbaru
Authors: Safitri Dewi , Hallilah Hallilah
Published: February 2025

Penelitian ini membahas tentang Implementasi model pembelajaran Problem Based Learning pada mata pelajaran PAI di SMA Plus Citra Madinatul Ilmi Banjarbaru. Rumusan masalah dalam penelitian ini adalah sebagai berikut, 1) Bagaimana Implementasi Model Pembelajaran Problem Based Learning pada mata pelajaran PAI Kelas XI di SMA Plus Citra Madinatul Ilmi Banjarbaru, 2) Apa faktor pendukung dan penghambat Implementasi Model Pembelajaran Problem Based Learning Pada Mata Pelajaran PAI Kelas XI di SMA Plus Citra Madinatul Ilmi Banjarbaru. Dalam pengumpulan data, penulis menggunakan teknik observasi, wawancara dan dokumentasi. Sedangkan teknik pengolahan data dilakukan dengan pengumpulan data, klasifikasi data, editing, serta interpretasi data. Selanjutnya, dianalisis secara deskriptif pendekatan kualitatif, jenis penelitian ini lapangan (field research) dan mengambil kesimpulan secara induktif. Implementasi Model Pembelajaran Problem Based Learning Pada Mata Pelajaran PAI Kelas XI di SMA Plus Citra Madinatul Ilmi Banjarbaru terlaksana sesuai dengan pelaksanaan model pembelajaran Problem Based Learning. Faktor pendukungnya adalah latar belakang pendidikan dan kemampuan guru Pendidikan Agama Islam, sikap antusias siswa, sarana dan prasarana yang baik dan memadai, lingkungan yang kondusif. Faktor penghambatnya adalah keterbatasan waktu dalam pelaksanaannya, perbedaan karakter siswa saat belajar, dan lingkungan sekolah.uliskan abstrak dalam bahasa indonesia yang merupakan rangkuman dari artikel.
An Analysis of Teachers’ Teaching Style in Teaching Writing Skills at SMA Negeri 2 Banjarmasin
Authors: Aprilliani Nia , Kamal Sirajuddin , Mu'in Fatchul
Published: February 2025

This study aims to analyze teachers' teaching style to teach English writing skills to students in grades XI and XII at SMA Negeri 2 Banjarmasin. Writing skills are crucial to English language learning in senior high schools in Indonesia. The research method was a descriptive qualitative method that utilized observation and interviews as the primary instruments. The research participants are English teachers in grades XI and XII at SMA Negeri 2 Banjarmasin. The results indicate that teachers' dominant teaching styles in teaching English writing at SMAN 2 Banjarmasin are formal authority and facilitator. Formal authority involves the teacher having complete control of the learning process, while the facilitator involves the teacher acting as a facilitator to help students acquire knowledge and skills independently. Formal authority and facilitator are two teaching styles to develop English writing skills in educational settings. This research provides an overview of the teaching approaches used in these settings. The findings have implications for improving the effectiveness of teaching English writing skills at the high school level.
Supervisi Pembelajaran pada Mahasiswa PLP Menggunakan Model Discovery untuk Mengajar Daring Bahasa Indonesia di Kelas X IPA 2 SMAN 1 Banjarmasin
Authors: Fitriana Arina , Ngalimun Ngalimun
Published: February 2025

Penelitian ini dilakukan untuk mengetahui sejauh mana supervisi kegiatan yang dilakukan untuk mengatur dengan cara langusng yaitu melihat. Kegiatan penelitian dilaksanakan pada SMAN 1 Banjarmasin dengan melibatkan para mahasiswa PLP sebagai subjek penelitian. Supervisi pembelajaran ini dilakukan dengan cara observasi, wawancara, dan dokumentasi. Supervisi pembelajaran yang dilakukan oleh penyelia untuk menemukan kekurangan dan menmberikan perbaikan untuk lebih sempurna. Dalam kegiatan supervisi pembelajaran menggunakan aspek yang mengacu kepada hakikat supervisi pembelajaran, ruang lingkup supervisi pembelajaran, serta peran dan fungsi supervisi pembelajaran. Dari hasil yang diperoeh dalam penerapan di pembelajaran Bahasa dan Sastra Indonesia (lintas minat) dengan penerapan model discovery di kelas X IPA 2 SMAN 1 Banjarmasin ditemukan beberapa langkah kegiatan yang tidak efektif dilakukan saat pembelajaran secara daring. Oleh karena itu, supervisi pembelajaran ada untuk mengevaluasi hal tersebut dan memperbaiki untuk menjadi lebih baik. Dalam kegiatan PLP (Pengenalan Lapangan Persekolahan) pada mahassiswa yang menjadi supervisor atau penyelia ialah guru pamong.
Peran Badan Permusyawaratan Desa (BPD) Dalam Penyelenggaraan Pemerintahan Desa Di Desa Sungai Bakung Kecamatan Sungai Tabuk Kabupaten Banjar
Authors: Harun Tamliha , Jumarianto Jumarianto
Published: February 2025

Tujuan penelitian ini adalah untuk mengetahui bagaimana peranan Badan Permusyawaratan Desa (BPD) dalam Penyelenggaraan Pemerintahan Desa di Desa Sungai bakung Kecamatan Sungai Tabuk kabupaten banjar  . Penelitian ini menggunakan penelitian deskriptif-kualitatif, dengan teknik pengumpulan data wawancara, observasi dan dokumentasi, kemudian dianalisis secara kualitatif.  Hasil penelitian dapat dideskripsikan. Bahwa Peranan Badan Permusyawaratan desa (BPD)dalam Pemerintahan  Desa di Desa SungaiBakung Kecamatan Sungai Tabuk Kabupaten banjar 1. dalam menampung dan menyalurkan aspirasi masyarakat masih belum maksimal, karena kurang terjalinnya hubungan kemitraan yang sinergis antara BPD dan Pembakal ;   kurang disiplin dan kompaknya  sesama anggota BPD dalam melaksanakan tupoksinya ; dan  kurang percayanya anggota masyarakat terhadap BPD. 2. alam penyelenggaraan musyawarah desa , juga masih belum maksimal, karena tidak semua anggota BPD ikut terlibat aktif dalam musdes ;  masih rendahnya pengetahuan dan pemahaman anggota BPD terhadap penyelenggaraan musdes ; dan masih rendahnya kesadaran dan partisipasi masyarakat ikut terlibat dalam musdes. 3. Namun, peran dalam pembahasan dan penyepakatan rancangan peraturan desa (raperdes) bersama pembakal sudah cukup baik, karena BPD sudah dapat menunjukkan kerjasama kemitraan yang sinergis dengan pembakal dalam pembahasan dan penyepakatan raperdes ; dan BPD dalam proses  pembahasan dan penyepakatan bersama Pembakal  sudah sesuai dengan prosedur dan ketentuan yang berlaku.
"Vi er deres stemmer!"
Authors: Thim Therese
Published: February 2025

Da Woman Life Freedom-bevægelsen landede i de dansk-iranske kvinders Instagram-feeds, blev kvinderne ikke blot vidner til en social bevægelse i Iran. De blev en del af den – både affektivt og politisk. Med en digital etnografisk tilgang og baseret på feltarbejde i foråret 2023 undersøger denne artikel, hvordan 10 dansk-iranske kvinder deltog i WLF. Artiklen opererer i et krydsfelt mellem studier af diaspora, tilhørsforhold, teknopolitik, sociale bevægelser og affekt. Ved at rette opmærksomheden mod dansk-iranske kvinder bosat i København har jeg her et translokalt perspektiv på deres deltagelse i WLF-bevægelsen. Med afsæt i Sarah Ahmeds (2014) affektteori identificeres tre typer Instagram-indhold som sticky signs, der førte smittende følelser med sig. Informanterne tog del i iranernes håb, mod og smerte, og de allierede sig affektivt med WLF’s budskaber. Artiklen viser, hvordan de agerede som politiske iværksættere i diasporaen (Adamson 2012) både online og offline, og tilmed, hvordan de tog del i et transnationalt feministisk projekt. Slutteligt argumenteres der for, at deres deltagelse i WLF ikke kun forandrede deres politiske liv, men også deres diasporicitet (Tsuda 2019). De blev en del af et iransk diasporafællesskab i København, og på den måde relokaliserede de sig socialt. Herved viser artiklen, at de affektive forbindelser, der skabes gennem onlineaktivisme, kan forandre menneskers tilhørsforhold og lokale livsverdener.
Doktorens Bord: Eva I. Otto: At kode værdi(er)
Authors: I. Otto Eva
Published: February 2025

Doktorens Bord: Eva I. Otto: At kode værdi(er)
Doktorens Bord: Rasmus Rask Poulsen: Verdensarvens åndelige arvinger
Authors: Rask Poulsen Rasmus
Published: February 2025

Doktorens Bord: Rasmus Rask Poulsen: Verdensarvens åndelige arvinger
Doktorens Bord: Erika Skov: Kampen om passage
Authors: Skov Erika
Published: February 2025

Doktorens Bord: Erika Skov: Kampen om passage
Danske resuméer
Authors: Madsen My
Published: February 2025

Danske resuméer
Gamle og kommende numre
Authors: Madsen My
Published: February 2025

Gamle og kommende numre
Call for papers: Forpligtelser
Authors: Madsen My
Published: February 2025

Call for papers: Forpligtelser
Sistem Penerapan Kesehatan Keselamatan Kerja (K3) Area Berbahaya Berbasis Android
Authors: Aswan Ambo  , Baco Syarifuddin , Junaedy
Published: February 2025

Penelitian ini bertujuan untuk merancang dan mengembangkan aplikasi edukasi Kesehatan dan Keselamatan Kerja (K3) berbasis Android yang efektif dan efisien. Dengan meningkatnya angka kecelakaan kerja dan penyakit akibat kerja, penting untuk meningkatkan kesadaran dan pengetahuan pekerja tentang K3. Metode yang digunakan dalam penelitian ini adalah Rapid Application Development (RAD), yang meliputi analisis kebutuhan, desain sistem, pembuatan prototipe, evaluasi, dan implementasi. Penelitian ini dilakukan di PLN ULP Panakkukang, Makassar, selama dua bulan, dengan menggunakan perangkat keras dan perangkat lunak yang sesuai untuk pengembangan aplikasi. Hasil dari penelitian ini menunjukkan bahwa aplikasi yang dikembangkan dapat meningkatkan kesadaran pekerja tentang K3, serta memberikan informasi yang relevan mengenai bahaya dan prosedur keselamatan yang harus diikuti. Diharapkan aplikasi ini dapat menjadi alat bantu yang efektif dalam meningkatkan keselamatan kerja di area berbahaya dan berkontribusi pada pengurangan angka kecelakaan kerja.
Zakres i formy współpracy Prezesa Urzędu Komunikacji Elektronicznej z Prezesem Urzędu Regulacji Energetyki
Authors:   Zakład Prawa Handlowego i Gospodarczego na Wydziale Prawa i Administracji Uniwersytetu Rzeszowskiego, Małecka Elżbieta
Published: February 2025

Artykuł prezentuje od strony teoretycznoprawnej i praktycznej współpracę Prezesa UKE z Prezesem URE. W pierwszej części zostały zaprezentowane przepisy dotyczące współpracy obu organów oraz możliwe formy współpracy wypracowane przez doktrynę. Treścią drugiej części artykułu jest analiza przykładów współpracy Prezesa UKE z Prezesem URE opartych na następujących dokumentach: Memorandum w sprawie współpracy na rzecz przeciwdziałania zjawisku kradzieży i dewastacji infrastruktury (dalej: Memorandum) oraz Porozumieniu na rzecz likwidacji barier w inwestycjach telekomunikacyjnych i energetycznych (dalej: Porozumienie).
Modeling of Microwave-Assisted Extraction of Lycopene from Tomato Peels
Authors: Kuvendziev Stefan , Stojchevski Martin , Andreevska Martina , Lukanovska Violeta , Marinkovski Mirko , Lisichkov Kiril
Published: February 2025

Dry tomato peels were investigated as a natural source of lycopene in this study. Microwave-assisted extraction (MAE) was used for the isolation of bioactive compound of interest. The MAE was performed at a microwave power of 120, 230, and 385 W for a duration of 2, 5, 8, and 10 min. The concentration of lycopene in the separated extract with n-hexane was quantified by UV/Vis spectrophotometer. The absorbance at 501 nm was selected for the determination of lycopene content and the calculation of lycopene yield (mg/100 g). An adequate feedforward artificial neural network (ANN) model with architecture 2-10-1, trained by the Levenberg-Marquardt (LM) backpropagation algorithm was developed for modeling the MAE process and for the prediction of the lycopene yield. The model predicted lycopene yield with a high coefficient of determination R2=0.9957 and low mean squared error MSE=0.475. The response surface methodology (RSM) was successfully applied and combined with the ANN model to optimize the MAE process with R2=0.9477 and a low mean absolute error MAE=1.84507. The analysis of variance showed that extraction time and time-squared have statistically significant effects on the lycopene yield. The created 3D response surface showed that the optimum lycopene yield was 27.25 mg/100g of tomato peels at the microwave power of 324 W and extraction time of 8.6 min.
Environmental Assessment of Particulate Matter Pollution Generated by the Exploitation of Heliopolis Aggregates Quarry
Authors: Djedid Faten , Bounouala Mohamed , Bouslama Amina , Benselhoub Aissa , Dovbash Nadiia , Bellucci Stefano
Published: February 2025

In recent decades, extractive industries such as mining and quarrying have contributed to increasing environmental deterioration, particularly airborne emissions. Therefore, we aim to evaluate the environmental impacts of particulate matter (PM1, PM2.5, and PM10) emitted during the exploitation operations of aggregates in the Heliopolis quarry in Guelma, Algeria. For this purpose, dust samples were analyzed using XRD and XRF spectroscopy techniques. While preparing the gravel, we monitored air quality using a specialized device and analyzed flora samples from near the Heliopolis aggregates quarry. Furthermore, we conducted chemical and physical analyses of surface water samples and soil from a nearby farm. The obtained results show that the concentrations of PM (particulate matter) exceeded the WHO limit values for PM10 (50 µg/m3) and PM2.5 (25 µg/m3) within 24 hours. This was particularly noticeable in sampling stations S1 and S2, where the PM2.5 concentration was at 520 µg/m3 and PM10 at 684 µg/m3, and 516 µg/m3 and PM10 at 676 µg/m3, respectively. According to the XRD and XRF analyses, the quarry dust contains various minerals, including oxides and heavy metals. An analysis of the plants surrounding the Heliopolis quarry confirms the presence of dust containing the same mineral elements emitted from the quarry on the leaves and branches of trees, which hinders their natural growth and blocks sunlight.
Reduction of Hexavalent Chromium by Nano Zero-Valent Iron
Authors: Stojchevski Martin , Kuvendziev Stefan , Bozinovski Zoran , Marinkovski Mirko , Lisichkov Kiril
Published: February 2025

Hexavalent chromium is a toxic form of chromium that has significant health and environmental implications. Reducing hexavalent chromium to trivalent chromium is a crucial step in immobilizing and removing Cr(VI) from water resources. Nano zero-valent iron (nZVI) as an electron-donating agent was used for Cr(VI) reduction in aqueous solution. The effect of contact time and initial concentration of nano zero-valent iron on Cr(VI) reduction was studied. The process of Cr(VI) reduction was designed and optimized using response surface methodology. The results indicated an enhancement in the Cr(VI) reduction ratio with increasing initial concentration of nano zero-valent iron and contact time. A second-order polynomial equation was used to model the correlation between the independent and dependent variables. The utilized model effectively predicted the response variable based on the input variables with a high coefficient of determination (R2) of 0.9475 and a correlation coefficient (R) of 0.9734. Additionally, the accuracy of the fitted model was demonstrated by the low values of the mean squared error (MSE) at 0.04315 and the sum of squared errors (SSE) at 0.06562. The optimal conditions for reducing Cr(VI) in aqueous solution using nano zero-valent iron were determined to be an initial nZVI concentration of 15 mg/L and a contact time of 209 min.
Personalized Medicine in Oncology: Ethical Considerations and Current Practice
Authors: Krehić Jasmina , Banjin Maja
Published: February 2025

Personalized Medicine aims to provide targeted therapy specifically designed according to inherited and/or acquired risk factors present in different subgroups of patients. One of the milestones in tumor research was the realization that tumors are much more complicated and dynamic than it was believed 20 years ago. From year to year, thanks to the extreme advances in molecular oncology, genomics and proteomics, our knowledge of tumors keeps growing, which has led to the emergence of new drugs that target the weaknesses od tumors. Molecular pathways, based on knowledge of genetic characteristics, have identified possible therapeutic targets for certain groups of patients within a seemingly unique clinical phenotype or disease. Stratifying complex and heterogeneous groups of patients in this way led to a better definition of disease subgroups, with a more precise risk-benefit ratio. Selecting patients who will respond to a given drug and avoiding exposure to potential side effects of patients who will not respond to therapy increases the effectiveness of the drug, reduces the risk of unnecessary side effects or drug interactions that could cause serious complications and significantly increase treatment costs. In parallel with the advancement of personalized medicine, with all its advantages, new ethical considerations are being raised, especially issues of patient privacy, confidentiality, data protection, and patients’ rights to fairness. The training on how to handle moral and ethical dilemmas while taking into account social, religious, and local societal values and practices can be very beneficial for the healthcare professionals and treating oncologists.
Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization
Authors: Zhang Yafan , Silvernail Irene , Lin Zhuyang , Lin Xingcheng
Published: February 2025

Sequence-specific DNA recognition underlies essential processes in gene regulation, yet methods for simultaneous prediction of genomic DNA recognition sites and their binding affinity remain lacking. Here, we present the Interpretable protein-DNA Energy Associative (IDEA) model, a residue-level, interpretable biophysical model capable of predicting binding sites and affinities of DNA-binding proteins. By fusing structures and sequences of known protein-DNA complexes into an optimized energy model, IDEA enables direct interpretation of physicochemical interactions among individual amino acids and nucleotides. We demonstrate that this energy model can accurately predict DNA recognition sites and their binding strengths across various protein families. Additionally, the IDEA model is integrated into a coarse-grained simulation framework that quantitatively captures the absolute protein-DNA binding free energies. Overall, IDEA provides an integrated computational platform alleviating experimental costs and biases in assessing DNA recognition and can be utilized for mechanistic studies of various DNA-recognition processes.
Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts
Authors: Stauber Tino , Moschini Greta , Hussien Amro A , Jaeger Patrick Klaus , De Bock Katrien , Snedeker Jess G
Published: February 2025

Tendinopathies are debilitating diseases currently increasing in prevalence and associated costs. There is a need to deepen our understanding of the underlying cell signaling pathways to unlock effective treatments. In this work, we screen cell signaling pathways in human tendinopathies and find positively enriched IL-6/JAK/STAT signaling alongside signatures of cell populations typically activated by IL-6 in other tissues. In human tendinopathic tendons, we also confirm the strong presence and co-localization of IL-6, IL-6R, and CD90, an established marker of reparative fibroblasts. To dissect the underlying causalities, we combine IL-6 knock-out mice with an explant-based assembloid model of tendon damage to successfully connect IL-6 signaling to reparative fibroblast activation and recruitment. Vice versa, we show that these reparative fibroblasts promote the development of tendinopathy hallmarks in the damaged explant upon IL-6 activation. We conclude that IL-6 activates tendon fibroblast populations which then initiate and deteriorate tendinopathy hallmarks.
Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation
Authors: Isbister James B , Ecker András , Pokorny Christoph , Bolaños-Puchet Sirio , Egas Santander Daniela , Arnaudon Alexis , Awile Omar , Barros-Zulaica Natali , Blanco Alonso Jorge , Boci Elvis , Chindemi Giuseppe , Courcol Jean-Denis , Damart Tanguy , Delemontex Thomas , Dietz Alexander , Ficarelli Gianluca , Gevaert Mike , Herttuainen Joni , Ivaska Genrich , Ji Weina , Keller Daniel , King James , Kumbhar Pramod , Lapere Samuel , Litvak Polina , Mandge Darshan , Muller Eilif B , Pereira Fernando , Planas Judit , Ranjan Rajnish , Reva Maria , Romani Armando , Rössert Christian , Schürmann Felix , Sood Vishal , Teska Aleksandra , Tuncel Anil , Van Geit Werner , Wolf Matthias , Markram Henry , Ramaswamy Srikanth , Reimann Michael W
Published: February 2025

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study
in vivo
. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a model comprising eight somatosensory cortex subregions, 4.2 million morphological and electrically-detailed neurons, and 13.2 billion local and mid-range synapses.
In silico
tools enabled reproduction and extension of complex laboratory experiments under a single parameterization, providing strong validation. The model reproduced millisecond-precise stimulus-responses, stimulus-encoding under targeted optogenetic activation, and selective propagation of stimulus-evoked activity to downstream areas. The model’s direct correspondence with biology generated predictions about how multiscale organization shapes activity; for example, how cortical activity is shaped by high-dimensional connectivity motifs in local and mid-range connectivity, and spatial targeting rules by inhibitory subpopulations. The latter was facilitated using a rewired connectome which included specific targeting rules observed for different inhibitory neuron types in electron microscopy. The model also predicted the role of inhibitory interneuron types and different layers in stimulus encoding. Simulation tools and a large subvolume of the model are made available to enable further community-driven improvement, validation and investigation.
New record of Frilled shark Chlamydoselachus anguineus Garman, 1884 (Chondrichthyes: Hexanchiformes) in the South Pacific Ocean
Authors: Indurain Maria J. , Mancilla Angel , Brizuela Leandro , Vargas-Caro Carolina , Bustamante Carlos
Published: February 2025

Frilled sharks are rarely observed and limited information is available regarding their life history. The global number of records for these sharks does not exceed 40, with most sightings reported in the Western Pacific Ocean. In 1976, one specimen was recorded for the first time in the South East Pacific Ocean; however, this study provides new evidence for the presence of Chlamydoselachus anguineus in Chilean waters, extending its distribution range 850 km south of the previous record. The morphological features of all specimens from Chile are discussed, supplementing previous observations and adding to the existing knowledge on this species in the Pacific Ocean.
Adopting Delayed Cord Clamping in Neonates who Cry/Breathe at Birth: A Quality Improvement Project at a Tertiary Care Hospital in Bengaluru, Karnataka, India
Authors: Gowtham R , Suman MG , Madhusudan Megha Varsha , Sandhya V
Published: February 2025

Introduction: Delayed Cord Clamping (DCC) involves waiting to clamp the umbilical cord for a duration of usually 60 seconds to three minutes following the baby’s birth. This practice has garnered increasing attention due to its potential to significantly improve neonatal outcomes.

Aim: To increase DCC rates at study Institute, by about 80% in neonates who breathe and cry at birth.

Materials and Methods: This Quality Improvement (QI) study was carried out in the Department of Paediatrics at Dr. BR Ambedkar Medical College and Hospital in Bengaluru, Karnataka, India, from 1st September 2023 to 15th October 2023 (a period of 6 weeks). This project was planned and conducted with a multidisciplinary team and aimed to increase DCC rates among deliveries conducted (fitting the inclusion criteria) in the Institute, abiding by the World Health Organisation (WHO) protocol.

Results: This QI project increased rates of DCC with each Plan- Do-Study-Act cycle (PDSA), ultimately meeting the aim over six weeks, increasing from zero to 87.87%.

Conclusion: Simple and inexpensive interventions, such as providing education, repetitive reinforcement and collaborative teamwork with minimal resources, quickly led to improvements in DCC rates. DCC presents significant benefits for neonatal health, particularly in improving iron status and supporting cardiovascular and respiratory transitions.
Test-retest Reliability of Balance Error Scoring System in Individuals with Osteoarthritis Knee: A Cross-sectional Study
Authors: Saha Mousumi , Aranha Vencita Priyanka , Chatterjee Subhasish , Samuel Asir John , Goyal Manu , Goyal Kanu
Published: February 2025

Introduction: Osteoarthritis (OA) of the knee is a degenerative joint disease that leads to changes not only in the articular cavity but also in the ligaments, tendons and muscles. These structures play an important role in human balance, which is important for daily activities. Due to the degeneration of ligaments, tendons and muscles, OA of the knee results in balance impairment.

Aim: To evaluate the test-retest reliability of the Balance Error Scoring System (BESS) in patients with OA of the knee.

Materials and Methods: This cross-sectional study was conducted at Department of Physiotherapy, MMIPR, MMDU, Ambala, Haryana, India, from March 2023 to April 2024. A total of 20 participants were recruited for the study and balance was evaluated using BESS on a firm surface, first in double limb stance, then in single limb stance and finally in tandem stance, both with eyes open and closed. A single rater conducted the same process twice on a foam surface. Descriptive statistics were used to represent the demographic characteristics of the participants. Reliability was examined using both Intraclass Correlation Coefficients (ICCs) and Cronbach’s alpha was executed to check internal consistency.

Results: The mean age of the participants in the present study was 49.4±10.6 years and the Body Mass Index (BMI) was 26.2±4.2. Both males 9 (45%) and females 11 (55%) were recruited for the present study. When comparing the demographic characteristics between males and females using an independent t-test, it revealed that no significant difference exists between them. The reliability analysis demonstrated excellent reliability for all parameters of BESS (ICC: 0.9). Cronbach’s alpha for all parameters was also 0.9. The limits of agreement plotted with the Bland-Altman plot indicated an excellent level of agreement, as the maximum scores fell within the 95% Confidence Interval (CI).

Conclusion: Based on the findings o the present study, the authors can conclude that BESS is a reliable tool for balance assessment in patients with OA of the knee.
Comparative Evaluation of the Effectiveness of Manual and Electric Toothbrushes in Blind Children: A Randomised Controlled Trial
Authors: Thanalakshme PS , Ramesh R
Published: February 2025

Introduction: Plaque removal is vital for preventing gingivitis and periodontitis, while maintaining oral hygiene is crucial for overall health. Blind children face unique challenges in oral care due to their reliance on touch rather than visual cues, which makes proper brushing difficult. Although research is limited, electric toothbrushes have been proposed as a solution to help blind children remove plaque more effectively by compensating for their reduced ability to visually monitor their brushing technique. Further studies are needed to confirm their benefits.

Aim: To evaluate the effectiveness of manual and electric toothbrushes in promoting better oral hygiene in visually impaired children in Palayamkottai, Tirunelveli District.

Materials and Methods: A randomised controlled clinical trial conducted at a high school for the blind in Palayamkottai, Tirunelveli district, Tamil Nadu, India on 120 blind chidren aged 6-12 years. The study participants was divided into Group 1, the manual toothbrush group, received a standard soft-bristle manual toothbrush (Colgate Sanxiao Co., Ltd., No. 8 Gaolujie Road, Guang Ling District, Yangzhou, 225111). In Group 2, the electric toothbrush group, participants were provided with a MINISO electric toothbrush with soft silicone bristles. Key parameters- Plaque Index (PI), Patient Hygiene Performance (PHP) index, Decayed, Missing, and Filled Teeth (DMFT) index, and Ayesha’s Oddbods Dental Anxiety Scale (AODAS) were measured at baseline, three months, and six months. Descriptive statistics were used to summarise demographic and clinical data. Repeated measures Analysis of Variance (ANOVA) were used to analyse the changes in the PI, PHP Index, and DMFT indices, as well as anxiety levels over time. A paired t-test was used to compare oral health outcomes and anxiety levels between the two groups.

Results: Over the course of six months, the study showed that manual toothbrushes were superior to electronic toothbrushes in enhancing oral health in blind children. The PI (2.4±5.04 to 0.39±0.49), PHP Index (2.24±0.65 to 0.45±0.50), and DMFT Index (2.45±0.50 to 0.53±0.54) all significantly decreased in Group 1 (manual), while Group 2 (electric) exhibited less noticeable changes. Furthermore, compared to Group 2 (32.7±5.3 to 11.7±3.7), dental anxiety decreased more in Group 1 (32.8±5.3 to 7.9±3.2).

Conclusion: In present study, manual toothbrushes outperformed electronic toothbrushes in enhancing oral health in blind children. Better gingival health and plaque clearance may have been facilitated by the tactile input of manual brushing. For blind children to maintain good oral health, it is advised to follow consistent oral hygiene practices and customise therapies.
A review of machine learning applications in aviation engineering
Authors: Koul Parankush
Published: February 2025

This review paper investigates how machine learning (ML) has transformed multiple facets of aviation engineering. The work demonstrates substantial progress in flight operations and air traffic management (ATM) optimization through frameworks such as Reinforcement-Learning-Informed Prescriptive Analytics (RLIPA) and deep reinforcement learning (DRL) techniques applied to conflict resolution. The study highlights how ML contributes to operational efficiency through faster computational processes and better decision-making abilities for those who control air traffic. The paper examines how leading firms such as SpaceX and Raytheon use ML technology to enhance manufacturing processes, including predictive maintenance (PdM) and autonomous systems development. The paper discusses ML implementation obstacles, including model interpretability, and highlights further research requirements for adapting to real-world issues such as changing traffic volumes and weather variations. Overall, the study demonstrates how ML technology can transform aviation engineering through enhancements in safety standards as well as operational and process efficiency.
Assessing the Challenges Faced by Adult Learners’ Academic Performance in Basic Education in Tanzania
Authors: Mwaibingila Godson , Malingumu Winfrida , Mrema Karoli
Published: February 2025

Although adult education is a key enabler for empowering individuals, fostering social and economic development, and addressing systemic barriers, making it integral to achieving the SDGs., there are still factors challenging them on academic performance. The purpose of this study is to examine the challenges faced by adult learners’ academic performance in basic education in Rukwa region, Tanzania.  The study employed mixed methods and convergent design. The study used a sample of 230 respondents. The adult learners were randomly selected while adult Learning center coordinators were purposively sampled from Rukwa region. The data were collected through questionnaires and In-depth interviews. The quantitative data were analysed using descriptive statistics in terms of percentages and frequencies with the aid of IBM Statistical Package for Social Sciences v26. Thematic analysis was also conducted for qualitative data. The findings revealed that adult learners in Tanzania face a variety of challenges that impact their academic performance and overall educational achievements. Key issues include inadequate funding, which affects infrastructure, teaching resources, and educator training; technological barriers, Family obligations, Time constraints, and Language barriers. The study concludes that challenges faced by adult learners on academic performance in basic education in Tanzania not only diminish the learners' confidence but also undermine the broader goal of empowering individuals through education to improve their socioeconomic status. The study recommends the adoption of a comprehensive support system on policy changes and innovative approaches such as flexible learning schedules, localized curricula, and relevant skills based on the environment people live in to balance the focus on addressing challenges that face adult learners in aligning with international standards and goals for inclusive education. Further studies should be developed focusing on evaluating the impact of implemented strategies and exploring new pathways to support adult education across diverse contexts.
A Review of Graph Traversal Algorithms: Techniques and Applications in Network Analysis
Authors: M. Ali Chreesk Sabah , Ibrahim Ibrahim Mahmood
Published: February 2025

This review identifies graph traversal methods as fundamental steps in network analysis that facilitate easy examination of relations within the network. In this review, we plan to discuss multiple graph traversal approaches like depth first search (DFS), breadth first search (BFS), their varieties and indicate how these techniques can be used in practice when analyzing networks. The following is a review methodology covering 10 articles for years 2019 – 2024. The study responds to the question of how to select algorithms for various types of networks with reference to their computational cost and speed. Thus, the authors describe the advantages and drawbacks of the reported techniques, and the topics serve as recommendations for the further advancement of technology. In this respect, the present review also serves to help to close the divide between theory and practice.