bluuebunny/crossref_metadata_2025 huggingface dataset:
Symmetry and Relative Equilibria of a Bicycle System
Authors:   Peking University, Xiong J. ,   Iowa State University, Jia Y.-B. ,   Peking University, Liu C.
Published: January 2022

In this paper, we study the symmetry of a bicycle moving on a flat, level ground. Applying the Gibbs – Appell equations to the bicycle dynamics, we previously observed that the coefficients of these equations appeared to depend on the lean and steer angles only, and in one such equation, a term quadratic in the rear wheel’s angular velocity and a pseudoforce term would always vanish. These properties indeed arise from the symmetry of the bicycle system. From the point of view of the geometric mechanics, the bicycle’s configuration space is a trivial principal fiber bundle whose structure group plays the role of a symmetry group to keep the Lagrangian and constraint distribution invariant. We analyze the dimension relationship between the space of admissible velocities and the tangent space to the group orbit, and then employ the reduced nonholonomic Lagrange – d’Alembert equations to directly prove the previously observed properties of the bicycle dynamics. We then point out that the Gibbs – Appell equations give the local representative of the reduced dynamic system on the reduced constraint space, whose relative equilibria are related to the bicycle’s uniform upright straight or circular motion. Under the full rank condition of a Jacobian matrix, these relative equilibria are not isolated, but form several families of one-parameter solutions. Finally, we prove that these relative equilibria are Lyapunov (but not asymptotically) stable under certain conditions. However, an isolated asymptotically stable equilibrium may be achieved by restricting the system to an invariant manifold, which is the level set of the reduced constrained energy.
On the Orbital Stability of Pendulum-like Oscillations of a Heavy Rigid Body with a Fixed Point in the Bobylev – Steklov Case
Authors:   Moscow Automobile and Road Construction State Technical University (MADI), Bardin B. S. ,   Moscow Aviation Institute (National Research University), Chekina E. A.
Published: January 2022

The orbital stability of pendulum-like oscillations of a heavy rigid body with a fixed point in the Bobylev – Steklov case is investigated. In particular, a nonlinear study of the orbital stability is performed for the so-called case of degeneracy, where it is necessary to take into account terms of order six in the Hamiltonian expansion in a neighborhood of the unperturbed periodic orbit.
Criteria of Motion Without Slipping for an Omnidirectional Mobile Robot
Authors:   Kalashnikov Izhevsk State Technical University, Mamaev I. S. ,   Ural Mathematical Center, Udmurt State University, Kilin A. A. ,   Kalashnikov Izhevsk State Technical University, Karavaev Yu. L. ,   Kalashnikov Izhevsk State Technical University, Shestakov V. A.
Published: January 2022

In this paper we present a study of the dynamics of a mobile robot with omnidirectional wheels taking into account the reaction forces acting from the plane. The dynamical equations are obtained in the form of Newton – Euler equations. In the course of the study, we formulate structural restrictions on the position and orientation of the omnidirectional wheels and their rollers taking into account the possibility of implementing the omnidirectional motion. We obtain the dependence of reaction forces acting on the wheel from the supporting surface on the parameters defining the trajectory of motion: linear and angular velocities and accelerations, and the curvature of the trajectory of motion. A striking feature of the system considered is that the results obtained can be formulated in terms of elementary geometry.
ON ALTINCI YÜZYIL DİVAN ŞAİRLERİNDEN VÂHİDÎ VE GÜLİSTÂN-I VÂHİDÎ ADLI ESERİ
Authors: ÖZÇAKMAK Fatma
Published: January 2022

Kanunî Sultan Süleyman devri şair ve yazarlarından olan Vahidî’nin asıl adı Abdulvahid’dir. Şair hakkında tezkirelerde ve edebiyat tarihlerinde verilen bilgiler sınırlıdır. Kınalızade Hasan Çelebi tezkiresine ve Osmanlı Müellifleri’ne göre İstanbul, Beliğ tezkiresine göre Bursa’da doğan Abdülvahid Çelebi, Kara Davud Efendi’nin (ö. 948/ 1541) torunu ve Süleyman Çelebi’nin oğludur. Önce ilmiye mesleğine intisap etmesine rağmen daha sonra tasavvuf yolunu seçmiş, 16. yy. tarikatlarından olan Zeyniyye’ye girmiştir. Doğum tarihi bilinmeyen şairin, ölüm tarihi için verilen bilgiler de ihtilaflıdır. Eserlerine dair sadece Osmanlı Müellifleri’nde, Saâdetnâme ve Şifâu’s-sudur adlı eserlerinin bulunduğu belirtilmiştir. Fakat Vahidî bunların yanı sıra Menâkıb-ı Hâce-i Cihân ve Netîce-i Cân, Kitâb-ı Cinânü’l-Cenân, Dürc-i Lügât, Tecâribü’l-İnsân, Pendnâme, Kıssa-i Seyyid Cüneyd ve Reşîde-i Arab ve Gülistân-ı Vâhidî’nin de müellifidir. Bu çalışmanın amacı, tezkirelerde ve edebiyat tarihlerinde hakkında yeterince bilgi bulunmayan Vahidî’yi ve ona ait olduğunu belirlediğimiz, ağırlıklı olarak dinî, tasavvufî ve ahlakî konuların işlendiği, manzum-mensur karışık bir şekilde tertip edilmiş olan Gülistân-ı Vâhidî adlı eserini edebiyat dünyasına etraflıca tanıtmaktır. Bu doğrultuda öncelikle şairin hayatı, eserleri, ilmî ve edebî yönü hakkında bilgi verilmiş; akabinde esere dair bilgiler (adı, yazılış tarihi) ifade edildikten sonra eser, muhteva, dil, üslup ve şekil özellikleri açısından değerlendirilmiştir.
JAPONCA VE TÜRKÇE İŞARET SÖZCÜKLERİNİN ALGISAL KULLANIMLARI ÜZERİNE
Authors: BALPINAR Metin
Published: January 2022

Bu çalışmada, Japonca ve Türkçedeki işaret sözcüklerinin algısal kullanımları (konuşucunun ve dinleyicinin özel ortak bilgisine dayalı işaret sözcüklerinin kullanımları) karşılaştırmalı olarak ilk kez ele alınmıştır. Çalışmada, algısal kullanım özelliğine sahip Japonca a- köklü işaret sözcükleriyle Türkçe şu ve o işaret sözcüklerinin dağılımsal özellikleri arasındaki benzerlik ve farklılıklara ışık tutulmuş, bu sözcüklerin işaret sözcükleri sistemi içinde nasıl karakterize edilmesi gerektiği hususuna değinilmiştir. Araştırmada genel olarak şu hususlara vurgu yapılmıştır: i) a- köklü sözcükler ad niteleyici ya da adıl olarak işlev görürken, şu ve o işaret sözcükleri sadece ad niteleyici olarak kullanılmaktadır, ii) Japonca algısal a- köklü işaret sözcükleri, konuşucu tarafından önemle belirtilmek istenen, söylem ortamına getirilmiş bir nesne, varlık, konu ya da olaya dinleyicinin dikkatini çekmek için kullanılabilmektedir, iii) şu ve o işaret sözcüklerinin dağılımı psikolojik yakınlık-uzaklık kavramına, a- köklü sözcüklerinin algısal kullanımları zamansal uzaklık kavramına duyarlıdır, iv) şu işaret sözcüğü psikolojik yakınlığı, o işaret sözcüğü psikolojik uzaklığı kodlamaktadır, v) Türkçedeki algısal işaret sözcüklerinin dağılımını belirlemede, göndergeye ilişkin konuşucunun kişisel görüş ya da tutumunu yansıtan niteleyici ifadelerin sözcedeki varlığı kadar konuşucunun iletişimsel amacı da önemli bir role sahiptir, vi) Japonca ve Türkçedeki algısal kullanımlar durumsal kullanımın bir çeşididir.
A review on the three written sources of the Masnavi of Sufism Mantiku'l-Tayr
Authors: BAŞÇI Veysel
Published: January 2022

Feriduddin Attar wrote his mystical masnavi called Mantık'ul-Tayr, influenced by the works that used similar allegories with the language of birds before him. The name of the aforementioned work and some concepts in its content are based on the Qur'an. The plot of the stories in the work is similar to the plot of the stories in the Risaletü't-Tayr works of İbn-i Sina and Ahmad Gazzālî. The bird-containing poems of Hakānî-i Shirvānî and Sānaî-i Gaznevî also influenced Attâr in this regard. Attâr reflected the bird parodies in the aforementioned treatises and poems to the fictional texture in Mantıkul Tayr, thus exhibiting an intertextual approach. Among the written sources that influenced Attar is al-Fūsul by Ebu Hanife Abdulvahab b. Muhammad who is a Karramiya scholar; Tafsir by Surabâdi who is one of the commentators close to the Karrāmis and Ebu'r-Reca el-Chachi’s Ravzatū'l Farikeyn, which is considered an Islamic law-mystical works of the first period. Because all three works were written before Mantık'ul-Tayr in the Nishabur region where Attâr was born and raised intellectually, symbolic bird stories and bird parodies are included in all three works. In order to reveal the similar points of these three works with Mantıku'l Tayr, first of all, information about the Mantıku'l Tayr masnavi is given in this article. It has been explained which moral and mystical thought the birds in the work correspond to. After the three written sources, which are thought to be effective in the emergence of the work are introduced in detail, they are examined in the light of the bird stories and narrations they contain.
Implementation of child-friendly inclusive schools for early childhood education in the city of Semarang
Authors: Indira Elizabeth Wahyu Margareth , Pramono Suwito Eko , Hermanto Agus , Arbarini Mintarsih , Pranuta M Nerru
Published: January 2022

The United Nations Convention on the Rights of the Child (UN-CRC) states that all children in the world have the right to the right to survive; the right to develop (right to be educated); and the right to protection. One of the points of the UN-CRC is the fulfillment of the rights of children with special needs. This study aims to identify the Implementation of Child-Friendly Inclusive Schools for Early Childhood Education in the Semarang City area. This research uses a case study quantitative approach. The data collection technique is done through questionnaires, interviews, observation, and documentation. While the data analysis technique starts from data display, data reduction, to drawing conclusions. The results of the study indicate that: In the implementation of Student Management, Curriculum Management Implementation, the implementation of education staff management, and in the implementation of facilities and infrastructure management, there is still a need for improvement and assistance from the department.
O comportamento informacional no tratamento de feridas é o mesmo em todo o Brasil?
Authors: Silva Bruno Santana da , Silva Paulo Vanzolini Moura da
Published: January 2022

Although informational behavior of nurses has already been investigated, factors that influence such behavior are still poorly understood. This work investigated whether and how variation in user's location influences his informational behaviors during wound care. Through an electronic questionnaire distributed between January and February 2020, 566 students and nursing professionals from 23 Brazilian states and from Federal District provided data on their geographical location and their informational behaviors during wound care. Variations in information sources use, in frequency of obtaining information and in way of recording information during wound care could be related to variations between country region, state and city of the participants. Up to 16% variation in informational behaviors was identified between cities of the same size, up to 51% variation in informational behaviors between different regions of the country, and up to 100% variation in informational behaviors between Brazilian states.
Análise bibliométrica e comparativa de publicações os casos das revistas Páginas a&b: arquivos e bibliotecas e Perspectivas em Ciência da Informação entre 2016-2020
Authors: Aleixo Marina , Fernandes Maria , Costa Gislane
Published: January 2022

Open access journals have gathered increasing prominence as researchers understand the importance of communicating their research to the general public and not just to the scientificcommunity. Journals such as Páginas a&b: arquivos e bibliotecas(Portugal) and Perspectivas da Ciência da Informação(Brazil) are good examples of this type of publication in the area of Information Science. In this sense, this study contributes with a bibliometric and comparative analysis of suchpublications between 2016-2020, in order to trace a trend profile based on them. In short, the themes divergefrom management to the Information-Documentation professionals' technical issues.
A expressão de singularidades em gêneros narrativos análise da classificação de fanfictions
Authors: Silva Bruna Daniele de Oliveira , Sabbag Deise Maria Antonio
Published: January 2022

The objective was to understand how fanfiction narrative genres are classified in repositories, describing the users perceptions and motivations to accomplishthe indexing. The research is descriptive and exploratory, with the Intensive Direct Observation method in virtual groups of fans who write and consume fanfictions;the data supported a qualitative analysis of the fanfictions narrative genres used in theirindexingin digital repositories. The analysis demonstrated that many of narrative genres used in the repositories express concern with the representation of gender, sexual and physical aspects. Furthermore, natural language words, neologisms and other foreignwords are re-semantized to represent narrative genres. It was concluded that narrative genres are used to classify the stories, to express singularities andtogive representation to demands of marginalized groups of the publishing market.
A semantização das representações imagéticas em ambientes digitais de museus do feminino
Authors: Silva Stephanie Cerqueira , Jorente Maria José Vicentini
Published: January 2022

In digit-virtual museums, image representations of artifactsexpand and helpin understanding information, they enhance relationships and stimulate visual narratives associated to memory and culture. The general objective of this study was to relate Walter Benjamin’s perceptions to contributions for information organization and presentation of women’s museums digital collections constituted by the convergence of languages to the emergence of Information Design. The study was of qualitative naturebased on the descriptive-exploratory type, with bibliographic study and exploratory analysis of the National Museum of Women in the Arts from the perspective of Information Science. The interdisciplinarity of the areas allows image representationsto be understood as a strategy to empower the knowledge creation process. The study concluded that their implementation in digital environments of women’s museums should be constituted to facilitate information access and sharing in the search for social discussions in contemporaneity.
O papel social das bibliotecas universitárias iniciativas da Biblioteca Central Irmão José Otão da PUCRS
Authors: Araujo Débora Kraemer de , Magnus Ana Paula Medeiros , Selbach Clarissa Jesinska , Debastiani Aline Matte , Handke Fernanda Becker
Published: January 2022

The article aims to address the social function of university libraries, in particular, the initiatives of the Irmão José Otão Main Library of PUCRS. Therefore, it discusses the Marist vision in which the Library is inserted, the practices adopted in serving the university and external community, the cultural actions developed, as well as the partnerships that promote humanization. The bibliographic reference also links the sustainable development proposed by Agenda 2030 with the role of libraries. It is concluded that the university library plays a broader role than just serving the academic community. By promoting equal access to information and practices that spread culture,this institution contributes to the development of conscientious and engaged citizens.
A Alfabetização Midiática e Informacional a produção científica em repositórios e bases de dados abertas da América Latina, Portugal e Espanha
Authors: Luce Bruno Fortes , Soares Laura , Estabel Lizandra Brasil
Published: January 2022

Media and Information Literacy (MIL), developed according to booklets of the United Nations Union for Education, Science and Culture (UNESCO), aims to allow students a more autonomous learning for the use of media and information as a way of articulating processes and social changes, that iswhy it is gaining more emphasis within today's society, in order to better relate to the informationthat surrounds us. This study has as central objective to carry out a survey within the open databases maintained by Latin American countries, Portugal and Spain, in order to identify the scientific production on MIL in the scopeof the academy. The search used the terms Media and Information Literacyand its translation into Spanish and Brazilian Portuguese, such as Alfabetização Midiática e Informacional, defined by UNESCO itself, and the use of Literacia Midiatica Informacionalfor European Portuguese. At the end it was possible to verify that thereare few works on the theme, that allthe recovered works are based on material developed by UNESCO, and that Brazil was the country that published the most on this theme.
SARS CoV- 2’ nin Dikey Geçişini Destekleyen Olgu
Authors: Ünal Zeynep , Çatak Arif İsmet , Karaaslan Erhan , Turan Halil , Ünal Murat
Published: January 2022

Doğum dönemindeki gebelerde ve yenidoğanlarda daha az COVID-19 vakasıyla karşılaşıldığı için, anneden bebeğe dikey geçiş olasılığını destekleyecek oldukça kısıtlı sayıda kanıt bulunmaktadır. Olgumuzda COVID-19 PCR pozitif anneden doğan COVID-19 PCR pozitif bebeği doğumdan taburculuğuna kadarki takiplerimize yer vererek litarature dikey geçiş olasılığı hakkında katkı sağlamayı amaçladık.
Bounds on the critical times for the Fisher-KPP equation
Authors: Rodrigo Marianito
Published: January 2022

The Fisher–Kolmogorov–Petrovsky–Piskunov (Fisher–KPP) equation is one of the prototypical reaction–diffusion equations and is encountered in many areas, primarily in population dynamics. An important consideration for the phenomena modelled by diffusion equations is the length of the diffusive process. In this paper, three definitions of the critical time are given, and bounds are obtained by a careful construction of the upper and lower solutions. The comparison functions satisfy the nonlinear, but linearizable, partial differential equations of Fisher–KPP type. Results of the numerical simulations are displayed. Extensions to some classes of reaction–diffusion systems and an application to a spatially heterogeneous harvesting model are also presented.
doi:10.1017/S1446181121000365
Deriving Weight From Big Data: Comparison of Body Weight Measurement–Cleaning Algorithms
Authors: Evans Richard , Burns Jennifer , Damschroder Laura , Annis Ann , Freitag Michelle B , Raffa Susan , Wiitala Wyndy
Published: January 2022

Background

Patient body weight is a frequently used measure in biomedical studies, yet there are no standard methods for processing and cleaning weight data. Conflicting documentation on constructing body weight measurements presents challenges for research and program evaluation.

Objective

In this study, we aim to describe and compare methods for extracting and cleaning weight data from electronic health record databases to develop guidelines for standardized approaches that promote reproducibility.

Methods

We conducted a systematic review of studies published from 2008 to 2018 that used Veterans Health Administration electronic health record weight data and documented the algorithms for constructing patient weight. We applied these algorithms to a cohort of veterans with at least one primary care visit in 2016. The resulting weight measures were compared at the patient and site levels.

Results

We identified 496 studies and included 62 (12.5%) that used weight as an outcome. Approximately 48% (27/62) included a replicable algorithm. Algorithms varied from cutoffs of implausible weights to complex models using measures within patients over time. We found differences in the number of weight values after applying the algorithms (71,961/1,175,995, 6.12% to 1,175,177/1,175,995, 99.93% of raw data) but little difference in average weights across methods (93.3, SD 21.0 kg to 94.8, SD 21.8 kg). The percentage of patients with at least 5% weight loss over 1 year ranged from 9.37% (4933/52,642) to 13.99% (3355/23,987).

Conclusions

Contrasting algorithms provide similar results and, in some cases, the results are not different from using raw, unprocessed data despite algorithm complexity. Studies using point estimates of weight may benefit from a simple cleaning rule based on cutoffs of implausible values; however, research questions involving weight trajectories and other, more complex scenarios may benefit from a more nuanced algorithm that considers all available weight data.
Incidence of Diagnostic Errors Among Unexpectedly Hospitalized Patients Using an Automated Medical History–Taking System With a Differential Diagnosis Generator: Retrospective Observational Study
Authors: Kawamura Ren , Harada Yukinori , Sugimoto Shu , Nagase Yuichiro , Katsukura Shinichi , Shimizu Taro
Published: January 2022

Background

Automated medical history–taking systems that generate differential diagnosis lists have been suggested to contribute to improved diagnostic accuracy. However, the effect of these systems on diagnostic errors in clinical practice remains unknown.

Objective

This study aimed to assess the incidence of diagnostic errors in an outpatient department, where an artificial intelligence (AI)–driven automated medical history–taking system that generates differential diagnosis lists was implemented in clinical practice.

Methods

We conducted a retrospective observational study using data from a community hospital in Japan. We included patients aged 20 years and older who used an AI-driven, automated medical history–taking system that generates differential diagnosis lists in the outpatient department of internal medicine for whom the index visit was between July 1, 2019, and June 30, 2020, followed by unplanned hospitalization within 14 days. The primary endpoint was the incidence of diagnostic errors, which were detected using the Revised Safer Dx Instrument by at least two independent reviewers. To evaluate the effect of differential diagnosis lists from the AI system on the incidence of diagnostic errors, we compared the incidence of these errors between a group where the AI system generated the final diagnosis in the differential diagnosis list and a group where the AI system did not generate the final diagnosis in the list; the Fisher exact test was used for comparison between these groups. For cases with confirmed diagnostic errors, further review was conducted to identify the contributing factors of these errors via discussion among three reviewers, using the Safer Dx Process Breakdown Supplement as a reference.

Results

A total of 146 patients were analyzed. A final diagnosis was confirmed for 138 patients and was observed in the differential diagnosis list from the AI system for 69 patients. Diagnostic errors occurred in 16 out of 146 patients (11.0%, 95% CI 6.4%-17.2%). Although statistically insignificant, the incidence of diagnostic errors was lower in cases where the final diagnosis was included in the differential diagnosis list from the AI system than in cases where the final diagnosis was not included in the list (7.2% vs 15.9%, P=.18).

Conclusions

The incidence of diagnostic errors among patients in the outpatient department of internal medicine who used an automated medical history–taking system that generates differential diagnosis lists seemed to be lower than the previously reported incidence of diagnostic errors. This result suggests that the implementation of an automated medical history–taking system that generates differential diagnosis lists could be beneficial for diagnostic safety in the outpatient department of internal medicine.
Cytotoxic Activity, and Molecular Docking of Indole Alkaloid Voacangine and Bisindole Alkaloid Vobtusine, Vobtusine Lactone from the Indonesian Plant: Voacanga foetida (Blume) Rolfe
Authors: Susanty Adriani
Published: January 2022

ABSTRACT

The purpose of this study was to isolate and test its cytotoxic activity starting from extract fraction and its isolate compound, then carried out molecular docking to confirm the potential biological activity of ligands (vocangine, vobtusine, and vobtusine lactone) against inhibition proteins (Bcl-2, Bcl-xL, and Mcl-1), activation protein Bax and activation of apoptotic execution protein Caspase-3. This research is an experimental quantitative study using column chromatography and HPLC methods in the isolation process, MTT assay in determining the cytotoxic activity, and molecular docking in determining the prediction of apoptotic mechanism. The cytotoxic activity of VFB-DA, VFB-DB, VFB-BuOH, VFB-DB4 fractions, voacangine compounds, vobtusine are very strong. while vobtusine lactone is moderate cytotoxic activity. The docking score for voacangine, vobtusine, and vobtusine lactone compounds against Bcl-2 is -9.93; -10.07; -9.03 kcal/mol, against Bcl-xl is -9.77; -11.69; -9.76 kcal/mol, against Mcl-1 is -10.70; -10.77; -9.53 kcal/mol, and for Bax is -8.99; -6.87; -6.99 kcal/mol, as well as against caspase3 is -12.05; -12.21; -12.02 kcal/mol. The cytotoxic activity of voacangine, vobtusine, and vobtusine lactone compounds is thought to cause cell death by suppressing Bcl-2 activity; Bcl-xl; and Mcl-1, increased Bax activity and increased caspase3 activity.

 

Key words: Voacanga foetida, in vitro, in silico
Immunomodulatory effect of petroleum ether extract and ethyl acetate fraction of bengkoang (Pachyrhizus erosus (L.) Urban) in vitro
Authors: Nurrochmad Arief , Sujono Tanti Azizah , Lukitaningsih Endang , Nugroho Agung Endro
Published: January 2022

Bengkoang (Pachyrhizus erosus (L.) Urban) contains phytosterol and the isoflavone daidzein, which are thought to have immunomodulatory activity. There have been no studies reporting on the immunomodulatory effects of bengkoang extract containing polar and semi-polar compounds, such as phytosterols and isoflavone-like compounds. The objective of this study was to evaluate the immunomodulatory effects of bengkoang extracts, including petroleum ether extract (PEE), methanol extract (ME), and the ethyl acetate fraction (EAF) of bengkoang, in vitro. The immunomodulatory effects of PEE, ME, and EAF of bengkoang were determined according to the phagocytic activity of macrophages based on phagocytosis of latex beads, lymphocyte proliferation, and detection of cytokine production of tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6), and interleukin-10 (IL-10) levels. Results: The phagocytic index and phagocytic capacity of ME, PEE, and EAF of bengkoang on macrophage cells were significantly increased (p < 0.05), whereas lymphocyte proliferation was unchanged compared with the control (p > 0.05), and ME of bengkoang enhanced the levels of the cytokines TNF-α and IL-6. In contrast, PEE and EAF of bengkoang decreased TNF-α and IL-6 levels compared with the control group. All of the bengkoang extracts decrease the production of the anti-inflammatory cytokine IL-10. In conclusion, this study showed that PEE, ME, and EAF of bengkoang could increase the non-specific immune response (phagocytic activity) but had a lesser effect on the specific immune response (lymphocyte proliferation). The ME of bengkoang acts as an immunostimulant by increasing the levels of the inflammatory cytokines TNF-α and IL-6 and decreasing those of the anti-inflammatory cytokine IL-10.
Expression, Microencapsulation of Recombinant Human Epidermal Growth Factor, and Release Study in Gastric Ulcer Representing Condition
Authors: Pratiwi Riyona Desvy
Published: January 2022

Recombinant human epidermal growth factor (rhEGF) has been studied and expressed in various expression systems. It has been also commercialized and clinically used, yet limited to topical diseases. However, being naturally expressed in different tissues, the rhEGF is potential to be applied not only for external wound and skin disorders, but also to regenerates internal damaged epidermal cells such found in gastric ulcer. In the recent study, chitosan microparticles were developed to facilitate delivery of the rhEGF and to overcome gastric degradation that majorly interfere protein, particularly rhEGF oral administration. The rhEGF was expressed in E. coli BL21(DE3) and purified using Ni-NTA chromatography. The refolded rhEGF showed proliferation activity on MC7 cells. rhEGF loaded chitosan microparticles were stable in the gastric and specifically released the loaded rhEGF in the high oxidative environment in acidic pH representing gastric ulcer condition.
HEPATOPROTECTIVE EFFECT OF BANANA PEEL FLOUR ON HISTOLOGICAL AND LIVER FUNCTION IN DIABETIC RATS
Authors: Nurrahma Herlin Ajeng , Meliala Andreanyta , Narwidina Paramita , Herwiyanti Sri
Published: January 2022

In diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) is closely linked to hyperglycemia metabolism. This study aimed to find out how a banana peel supplemented diet affected histological and liver function changes in streptozotocin-induced diabetic rats. Vitamins, minerals, dietary fiber, antioxidants, and tryptophan are all contained in banana peel flour (BPF). Serotonin is a neurotransmitter that has been linked to depression and anxiety. This post-test-only control group study was conducted on twenty-five male Wistar rats which were separated into five groups with different treatments. Groups II to V were diabetic rats model groups that consumed standard diet mixed with BPF 0%, 5%, 10%, and 20%, respectively, while group I was a healthy control group fed a standard diet. Hepatic enzyme transaminase (Alanine Aminotransferase-ALT and Aspartate Aminotransferase - AST) and Hematoxylin-Eosin (HE) staining were analyzed with the NAFLD score to examine the liver function and hepatocellular morphology. A change in liver function was observed, as well as a substantial change in the levels of ALT and AST. The NAFLD score with HE staining showed substantial improvements in liver morphology, which was better seen at a 20% BPF dose. The current study supported the hypothesis that BPF had a hepatoprotective effect in diabetic rats, which may be due to the mechanism of controlling the hepatic enzyme transaminase and inducing liver regeneration.
Immunostimulant Activity of Marchantia paleacea Bertol. Herb Liverwort Ethanol Extract in BALB/c Mice
Authors: Purkon Dicki Bakhtiar
Published: January 2022

Immunostimulants are compounds that can stimulate an immune response by increasing the activity of non-specific and specific components of the immune system (humoral and cellular) against certain infections and diseases. The liverwort plant species Marchantia paleacea Bertol. has long been used as a source of nutrition and empirical medicine. However, scientifically there is still not much research data on immunomodulators in these plants. This study aims to determine the activity of immunomodulators in the ethanol extract of the herb Marchantia paleacea Bertol. in male mice of BALB/c strain. Bioactive compounds from this plant were extracted by maceration method using 96% ethanol. Extract characterization and phytochemical screening were determined according to WHO guidelines and standard procedures from previous studies. The immunomodulatory activity of the extract was tested by carbon clearance method and lymphoid organ index (non-specific responses), primary and secondary antibody titer tests (humoral specific responses), IL-2 cytokine levels and IFN-ɣ from serum secondary antibodies and delayed-type hypersensitivity reaction/DTH (cellular specific response). The results of qualitative phytochemical screening contained flavonoid compounds, saponins, phenolics, tannins and steroids/triterpenoids. The results of the non-specific immune response immunomodulator test showed that the dose of 52 mg/kg bw had the largest phagocytic index of 1.52 which included strong immunostimulation (K > 1.5) and the organ spleen index of 0.55 ± 0.11 which increased significantly compared to the control (p<0.05). The data on the acquisition of specific immune responses in the primary and secondary antibody titer test in the three test extracts resulted in increased titer levels compared to the control and at a dose of 52 mg/kg bw could significantly increase the levels of IL-2 cytokines in the control group (p<0,05). Meanwhile, in the DTH test, doses of 13 and 26 mg/kg bw could significantly increase the thickness of the soles of mice compared to controls (p<0.05).
THE METABOLITE FINGERPRINTS, ANTIMALARIAL ACTIVITIES AND TOXICITIES OF ARTOCARPUS CHAMPEDEN STEMBARK FROM VARIOUS REGIONS IN INDONESIA
Authors: Taufik Imam , Widyawaruyanti Aty , Yuwono Mochammad
Published: January 2022

In Indonesia, cempedak (Artocarpus champeden Spreng) stembark from family of moraceae had been traditionally used for malarial treatment. Difference in the location of growth could cause the difference of metabolite fingerprints. As a result, there might be different toxicity and antimalarial activity in the same plants. The goal of this study was to obtain the fingerprints of the metabolites found in A. champeden stembark from different parts of Indonesia in order to authenticate and control the extract's quality. Fingerprints were performed using the HPTLC-Densitometry technique, in vitro toxicity and antimalarial activity were also determined using MTT assay and HRP2 assay. The correlation between metabolite fingerprints, toxicity and antimalarial activity was analysed using chemometrics tools: Principle Component Analysis (PCA), Partial Least Square (PLS) and Hierarchical Clustering Analysis (HCA). As a result, there is significant difference between fingerprints and toxicity profiles of A. champeden (p<0.05), whereas for antimalarial profiles, there is no significant difference between of them (p>0.05). Meanwhile, the nutrients (copper, zinc and manganese) are suspected to be responsible for the metabolite content. Besides morachalcone-A, compounds with Rf values ​​of 0.66 and 0.63 can be proposed as additional markers because they have responsibility for antimalarial activity and toxicity.
SYNTHESIS OF CR(III)-ASPARTATE AND CU(II)-ASPARTATE COMPLEXES AS ANTIDIABETIC COMPOUND
Authors: Hadi Sutopo , Ambarwati Yuli , Firguna Dinda S. , Bahri Syaiful , Laila Aspita
Published: January 2022

The synthesis of Cr(III)-Aspartate and Cu(II)-Aspartate complexes has been successfully conducted by reacting CrCl3·6H2O and CuCl2·2H2O metals with aspartic acid. Therefore, this study aimed to synthesize Cr(Asp)2Cl2 and Cu(Asp)Cl2 as well as test their antidiabetic effects. The synthesis results of Cr(Asp)2Cl2 and Cu(Asp)Cl2 in the form of light purple and blue solids were 0.3001 g and 0.3095g with a yield of 95.14% and 95.02%, respectively. Furthermore, the antidiabetic test used 27 male mice (Mus musculus) with nine treatments for 21 days. The data obtained were analyzed statistically using analysis of variance, and the antidiabetic activity was expressed in percent glucose lowering. The result showed a decrease in blood glucose levels in mice after alloxan induction, with percent glucose lowering (%GL) values of 74.1874% for Cr(Asp)2Cl2 and 76.1337% for Cu(Asp)Cl2 compounds. Therefore, the Cr(Asp)2Cl2 and Cu(Asp)Cl2 compounds can be used as antidiabetic in mice which are also potentially used as metal-based drugs for the treatment of DM.
A Novel Stability Study of Simvastatin Generic Tablet in Public Pharmacy Facilities of Purwakarta District, Indonesia
Authors: Muchtaridi Muchtaridi , Yulianita Rini , Sopyan Iyan , Mohd Gazzali Amirah
Published: January 2022

Drug stability is one of the most important criteria for producing safe, excellent and effective products. Some environmental factors that influence drug stability are light, temperature, and humidity. Simvastatin is a cholesterol-lowering drug that is known to be sensitive to high temperature and humidity. The purpose of this study is to analyze the effect of 6 months of real-time storage conditions on the stability of generic simvastatin tablets in public pharmacy facilities. This study used simulation method with 4 brands of simvastatin generic tablets with two different strengths (10 mg and 20 mg). In the process, the sample was conditioned in 6 different regions for 6 months. The results of temperature and humidity monitoring showed 2 locations at ≤ 25 ° C, 4 locations had a temperature of ≥ 25 °C and all locations had humidity > 65 %. The drug was evaluated for physical and chemical quality parameters at months 0, 3, and 6. After being stored for 6 months, the tablets showed a decrease in disintegration time and an increase in the friability, showing lack of durability. Similarly, there was a decrease in the content concentration in the tablets but fortunately the level was still within the accepted specification range (90 – 110 %). However, there was one tablet that did not meet the dissolution test requirements after the storage duration (Q ≤ 75 % at 30 minutes). The results of the stress test showed that simvastatin degraded in all conditions. This stress test confirmed the extreme instability of simvastatin.  Poor storage conditions can reduce the quality of generic simvastatin tablets, thus a well-controlled environment is vital in pharmacy facilities.
Prospectiva estratégica del subsector comercio del municipio de Ipiales – Colombia, hacia el año 2030
Authors: Chalapud Eduardo D.
Published: January 2022

En el presente artículo se realiza un estudio prospectivo del subsector comercio al por mayor y menor en la zona de frontera colombo – ecuatoriana, específicamente en el municipio de Ipiales hacia el año 2030. Su importancia en la dinámica económica la posiciona como la principal actividad y fuente generadora de empleo, por ello es necesario su fortalecimiento examinando la influencia de diversos factores indispensables en el presente y su desarrollo en el futuro. Se examinan los factores de incidencia que son convertidos a variables clave por expertos utilizando el método Mic Mac; mediante el análisis de actores se constata las relaciones de convergencia y divergencia entre ellos y se realiza los escenarios utilizando el análisis Morfológico. Por último, se clasifican estrategias inmediatas, reto y menos urgente a realizar que, con su implementación facilita el cumplimiento del escenario apuesta. Se busca con ello rediseñar la cadena de valor y de suministro, aprovechar la infraestructura vial, participar directamente con los centros de producción, fortalecer la asociatividad y el Clúster comercial de la frontera.
Experiencia organizativa y trabajo colectivo de PROVITEC -provivienda para los trabajadores de la educación del Cauca- en el suroccidente colombiano
Authors: Luna Fernández Nazly , Astorga Sergio Gustavo
Published: January 2022

PROVITEC (Provivienda para los trabajadores de la educación del Cauca) se constituye al interior del sindicato ASOINCA (Asociación de Institutores y Trabajadores de la Educación del Cauca), por docentes y trabajadores de la educación vinculados en Popayán y el Departamento del Cauca en Colombia, tras el terremoto de 1983. En el siguiente artículo de investigación se indaga su fecunda trayectoria organizativa marcada por sus protagonistas y el trabajo colaborativo, asociativo, etc. Se observan indicadores de aumentos de productividad por la unión de voluntades y esfuerzos (la solidaridad y el trabajo cooperativo convertidos en fuerza productiva), lo cual se aplica directamente en bienestar para los asociados y/o cooperativistas sin apropiación privada e individual de lo invertido y ganado en la organización y sus proyectos colectivos. De acuerdo a los marcos propuestos por Creswell (1998) y Dussel (1999) acordes con la investigación cualitativa, la investigación se construye desde un enfoque interpretativo crítico. A partir de entrevistas en profundidad estructuradas y la observación participante, se analizan sus prácticas que involucran el trabajo colectivo. Los hallazgos muestran que el trabajo colectivo, al ser llevado a las actividades cotidianas, fortalece las organizaciones de economía popular y solidaria, dando mayor cohesión y sentido de pertenencia en la lucha por su bienestar social, político y económico.
Divulgación de la información ambiental en páginas web en empresas cotizadas chilenas
Authors: Morales Parada Fernando , Vergara Puentes Doris , Jara Rodríguez Vanessa
Published: January 2022

No cabe duda de que la divulgación en temas de sostenibilidad es aporte a la problemática mundial medioambiental. En este sentido, este trabajo presenta un análisis de la divulgación de información relacionadas con los Objetivos para el Desarrollo Sostenible (ODS) en las páginas web de 107 compañías chilenas utilizando diferentes variables recogidas de forma dicotómica desde los sitios web corporativos a partir de una lista de chequeo para determinar un índice que permita medir la revelación de información relativa al medioambiente bajo un contexto de sostenibilidad, a partir de cinco índices propuestos. Entre los resultados observamos que las empresas divulgan más respecto a su gobierno corporativo y en menor medida en condiciones laborales. Asimismo, se observa que el sector minero presenta una mejor divulgación promedio, sin embargo, la industria agro-silvícola aún tiene mucho por mejorar en esta materia y las empresas de mayor tamaño y mejor EBIT igualmente se relacionan directamente con la mayor divulgación en internet de informaciones evaluadas.
Condiciones ocupacionales de los graduados del programa de economía en la Universidad de Nariño, Colombia
Authors: Hidalgo Villota Mario Eduardo
Published: January 2022

En este artículo se analizan las condiciones ocupacionales y el desempeño profesional de los economistas de la Universidad de Nariño, Colombia, en concordancia con la política universitaria de autoevaluación y mejora permanente de la calidad académica. Este es un estudio con enfoque mixto de tipo observacional, prospectivo, transversal y descriptivo, el cual incorpora en su análisis, información primaria recolectada a través de encuestas y entrevistas contestadas por un número representativo de graduados en el periodo 1979-I - 2020-II. El uso de métodos estadísticos y econométricos, así como el análisis riguroso de datos cualitativos, permite confirmar el éxito profesional de los economistas en su inserción laboral, el reducido tiempo de búsqueda en la consecución del primer empleo, la moderada tasa de desempleo, los avances en formación posgradual y la no discriminación laboral; a esto, se suma, el equilibrio salarial de género y la equitativa distribución del ingreso entre mujeres y hombres.
Consolidación legal y regulatoria del servicio público de las comunicaciones en Colombia 1847-2020
Authors: Tabarquino Muñoz Raúl Andrés
Published: January 2022

El objetivo es precisar la consolidación legal y regulatoria de las comunicaciones en Colombia como servicio público entre los años 1847-2020. La metodología se basa en un enfoque mixto -información primaria y secundaria. Los resultados evidencian que la estructura legal y regulatoria del servicio público de las comunicaciones en Colombia entre los años 1847 y 2020, a pesar de las diferentes ideologías y toma decisiones, responden a la premisa de aprendizaje institucional con alianzas y transferencia de conocimiento técnico por parte de actores internacionales y privados. La conclusión está enmarcada en un sector dinámico y progresivo, que a pesar que se regule como servicio público es muy diverso y complejo por la incidencia de la regulación internacional.
El currículo de matemáticas desde la cultura indígena: una revisión del estado del arte
Authors: Molano Franco Edwin , Blanco Álvarez Hilbert
Published: January 2022

El objetivo de este artículo es contribuir al conocimiento del estado de desarrollo de las investigaciones sobre la incidencia de la cultura indígena en el currículo de matemáticas desde una perspectiva política. Esta investigación es de tipo documental desarrollada con metodología cualitativa e interpretativa, la cual hizo uso del análisis de contenido con el software Atlas.ti. y la pregunta orientadora fue ¿de qué manera la cultura indígena incide en el nivel de los principios normativos, de las instituciones y de la praxis política a través del currículo? El material empírico fueron artículos, monografías de pregrado, trabajos de maestría y tesis doctorales, publicadas entre el año 2010 y 2020. Los resultados se presentan en tres niveles: en el nivel de los principios éticos se plantea el reconocimiento y respeto a la diferencia; en el nivel institucional se plantea la flexibilización del currículo para vincular otros saberes y prácticas, incluir a la comunidad, así como la reflexionar sobre valores, creencias y saberes; y en el nivel de la praxis política se propone la insubordinación creativa.
Envejecimiento y la transición de la estructura poblacional por edades en Colombia
Authors: Castellanos Elizabeth , Vega Indira , Cristancho Fajardo César
Published: January 2022

El objetivo de esta investigación es analizar el perfil sociodemográfico de las personas de edades avanzadas en Colombia. La principal fuente de información está constituida por los resultados de los Censos de Población y Vivienda, con énfasis en el realizado en 2018. En el desarrollo de la investigación se analizaron niveles, tendencias y desigualdades geográficas del envejecimiento poblacional en Colombia. En los resultados, se identificó que una de las principales transformaciones de la estructura poblacional de Colombia es el proceso de feminización de las edades avanzadas, impulsado por la mayor esperanza de vida al nacer de las mujeres. Por otro lado, se encontró una clara diferenciación de los roles de género en los hogares con población de edad, en la cual la mayoría de los hombres son identificados como jefes de hogar y tienen una mayor participación laboral hasta edades avanzadas y las mujeres son sus parejas y se encargan del cuidado del hogar y sus integrantes. Así mismo, se comprobó que la participación en la actividad laboral es una opción para las personas de edad con mejores condiciones económicas y acceso a pensiones; mientras que para las que acumulan mayores desventajas económicas no constituiría una opción sino una obligación.
USE OF ADDITIVE MANUFACTURING IN VETERINARY MAXILLOFACIAL PROSTHETICS
Authors: Klímová Jana , Findrik Balogová Alena , Trebuňová Marianna , Hudák Radovan , Živčák Jozef
Published: January 2022

The article is focused on orthodontic disorders and the use of additive production in solving problems in the maxillofacial area. Important information in veterinary orthodontics is the knowledge of the most common orthodontic disorders occurring in animals of various species and the consequences of not resolving these disorders. Dental health is no less important for both domestic and farm animals. With new approaches such as additive production, it is possible to achieve individualized aids that can be applied to any animal. The aim of the article is to draw attention to additive production and to point out its potential in the field of veterinary orthodontics. Examples of the use of additive production in this area can be found at the end of the work.
EFFECT OF NEURAC THERAPY ON PLANTAR PRESSURES DISTRIBUTION AND THE CENTER OF GRAVITY OF THE HUMAN BODY
Authors: Michalíková Monika , Bednarčíková Lucia , Ondrejová Bibiána , Barcalová Miroslava , Živčák Jozef
Published: January 2022

Nowadays, the pathophysiological posture is a problem for a large part of the population, which leads to a deterioration in the quality of life as a result of functional disorders of the human musculoskeletal system. The aim of the presented article is to point out the effectiveness of movement therapy for the correction of the pelvic position and subsequent adjustment of the body posture, which is evaluated by a change in the distribution of plantar pressures as well as the position of the center of gravity projection. Observations were made on three subjects who reported pain in different areas of the body as a result of incorrect body posture. Input and control measurements were performed on a baropodometer, and Neurac movement therapy in the Redcord system was applied between the individual measurements. The individual exercises were chosen specifically with regard to affect the specific muscle groups. After evaluating the measured data, it can be stated that the selected movement therapy has a significant effect on the correction of pathophysiological position, which is also demonstrated by changing the distribution of plantar pressures, adjusting the position of the center of gravity projection and also significantly eliminating painful symptoms and increasing movement comfort.