bluuebunny/crossref_metadata_2025 huggingface dataset:
UV Spectrophotometric Stability Indicating Method Development and Validation for the Determination of Finasteride Bulk and Dosage Form.
Authors: Nemane Shraddha T. , Gholve Sachin B. , Bhusnure Omprakash G. , Rajmanya Trupti M. , Kaulkhere Shivani V. , Waghmare Sagar S.
Published: September 2024

A simple, specific and economic UV spectrophotometric method has been developed using as diluents Methanol to determine the finasteride content in bulk and pharmaceutical dosage formulations. The quantitative determination of the drug has been carried out at a predetermined λmax of 255 nm, it was proved linier in the range 2-12 μg/mL and exhibited good correlation coefficient (R2=0.999) and excellent mean recovery (98-99%). LOQ and LOD were found to be1.178µg/ml and 5.40µg/ml respectively. The method was validated statically and by recovery studies for linearity, precision, repeatability and reproducibility as per ICH guideline. The obtained results proved that the method can be employed for the routine analysis of finasteride in bulk as well as in the commercial formulations.
Keywords: Finasteride, UV Spectroscopy, Method Validation.
Synthesis and Evaluation of Phenol Derivatives of Sulfonyl Chloride Quinoxaline
Authors: Goyal Rakesh , Sharma Mukesh , Ahuja Dharmendra , Jain Anurekha
Published: September 2024

The objective of the present study was to synthesize some new 7-sulfonate of 2, 3- Diphenyl quinoxaline which are more potential as antibacterial than parent quinoxalines. The present study was synthesis of derivatives of sulfonyl chloride quinoxaline and physicochemical and spectral characterization, in vitro antimicrobial screening against gram positive and gram negative bacteria.The concentration of derivatives used as 200 and 400 microgram initially. When 200 µg concentrations was used R6 shows sensitivity towards S. aureus and R6 shows sensitivity towards gram negative E. coli organism. When 400 µg used then R3, R5, and R6 shows sensitivity in case of gram positive organism. And in case of gram negative organism R5, R6 shows sensitivity.Azithromycin is used as Reference drug and a comparative study was done. As compare to reference drug all derivatives shows less sensitivity than S- Standard and R- quinoxaline derivatives.
Keywords: Diphenyl quinoxaline, QSAR, Quinoxaline, Phenol derivatives
Formulation Design and Pharmaceutical Considerations for Paediatric Patients: Current Status and Future Dimensions
Authors: Naman Subh , Madhavi Nupur , Singh Mela , Singh Preet Amol , Bajwa Neha , Baldi Ashish
Published: September 2024

Present day’s conventional pediatrics doses forms are not very attractive towards the children. Due to various reasons such as larger size, bitter taste etc. pediatrics patients rejects the present conventional doses form in many cases. So, there is need for development of some attractive and effective dosage form for children. Present day’s conventional pediatrics doses forms are not very attractive towards the children. Due to various reasons such as larger size, bitter taste etc. pediatrics patients rejects the present conventional doses form in many cases. So there is need for the development of some unconventional dosage forms that proves to be attractive towards the paediatrics populations. This review provides possible advantages and disadvantages of the present conventional dosage forms available for children. Hence present review introduces to various alternatives and unconventional dosage forms viz. effervescent granules / tablets, oral disintegrating tablets and medicated candies and their advantages and disadvantages.
Keywords: Effervescent granules, effervescent tab, medicated candy, Oral disintegrating tablet and pediatrics.
Development of Analytical Method to Monitor Dissolution of Bepotastine Besilate Tablet
Authors: Damle M. C. , Pardeshi K.K.
Published: September 2024

Bepotastine Besilate is an anti-histaminic drug and it is marketed as tablet of strength 10mg. In this study an attempt is made to monitor the dissolution of Bepotastine Besilate tablet. Dissolution study was done for marketed sample using phosphate buffer 6.8, phosphate buffer 4.5 and 0.1 N HCl as dissolution media. Samples were analysed using UV spectrophotometer, HPLC and HPTLC. Detection wavelength selected was 226nm. A chromatographic separation is achieved on a C18 column with a mobile phase consisting of acetonitrile, water with isocratic elution with flow rate 1ml/min. Solvents used for development in HPTLC were chloroform and methanol. Percentage release of bepotastine besilate was calculated by extrapolation of calibration curve. The results of three analytical methods were compared by applying One-Way ANOVA.
Keywords:  Bepotastine Besilate, Dissolution, UV, HPLC, HPTLC
Homology modeling and molecular docking studies for the identification of novel potential therapeutics against human PHD3 as a drug target for type 2 diabetes mellitus
Authors: Lanka Goverdhan , Bathula Revanth , Bhargavi Manan , Potlapally Sarita Rajender
Published: September 2024

PHD3 (Prolyl Hydroxylating Domain) 3 protein contains the HRE (Hypoxia Response Element) and plays an important role in regulating HIF subunits. The hydroxylating ability of PHD3 of HIF subunits makes PHD3 is a prominent therapeutic target to control type 2 diabetes mellitus. The structure based approach is used to design novel molecular entities against PHD3 protein. In this present work, a 3D homology model of PHD3 was generated by MODELLER9.9 as the experimental structure of PHD3 is not reported in the protein database.  The 3d structural model of PHD3 refined through energy minimization in VMD-NAMD interface. Active site of the target protein is identified by SiteMap module (Schrodinger suite), manual correlation technique using ClustalW software and literature studies. The asinex library of chemical structures subjected to the molecular docking at the PHD3 active site for the identification of potent inhibitors. The molecules resulted from molecular docking prioritized based on their docking score, glide energy. The ligand molecules are further prioritized with a rescoring parameter Prime-MM/GBSA by calculating binding free energies of final Ligand-Protein complexes. The identified novel leads are further evaluated with ADME properties for their druglikeness activity. The overall insights can further expedite for the development of novel molecular entities as potential inhibitors against PHD3 in type 2 diabetes mellitus.
Keywords: PHD3, homology model, VMD-NAMD, Prime-MM/GBSA, ADME, type 2 diabetes mellitus.
Development and Validation of RP-HPLC Method for Estimation of Etizolam in Bulk
Authors: Harde Shubhangi L. , Laware Ravindra B. , Kolhe Mahesh H.
Published: September 2024

The present research work describes a simple, accurate, precise, effective, stability indicating, RP-HPLC method for estimation of Etizolam in there tablet dosage form. A Reverse phase high performance chromatographic method was developed for estimation of Etizolam dosage. The separation was achieved by Cosmosil C18 (250mm×4.6ID, Particle size: 5 micron) and methanol: water in the proportion of 30:70v/v as mobile phase, at a flow rate 0.8ml/min. Detection was carried out at 242nm. For RP-HPLC method results of the validation indicate that the method was linear in the range of 100-600 µg/ml for Etizolam. The % recoveries for Etizolam obtained in the accuracy study were 99.77-99.51% respectively. The LOD for Etizolam were found to be 0.7877µg/ml. LOQ for Etizolam found to be 2.382µ/ml. Developed methods were found to be accurate, precise, rapid and stability indicating for estimation of Etizolam.
Keywords: Etizolam, RP-HPLC, tablet dosage form
Bioanalytical Method Development and Validation for Estimation of Daunorubicin and Cytarabine in Blood Plasma by Using RP-HPLC
Authors: Agrawal Ashish , Sharma Manoj
Published: September 2024

A simple, sensitive and selective RP-HPLC method was developed for estimation of Daunorubicin and Cytarabine in combined formulation by isocratically using 20 mM KH 2 PO 4 : acetonitrile (pH 2.5) in the ratio of 20:80 v/v as mobile phase, Prontosil C-18 column (4.6 x 250mm, 5μparticle size) column as stationary phase and chromatogram was recorded at 254nm. The validation studies are carried out and it’s fulfilling ICH requirements. The method is found to be specific, linear, precise (including both intra- and inter- day precision), accurate and robust. This proposed method may represent a valuable aid in the laboratory monitoring of the toxicity of anticancer chemotherapy.
Keywords: RP-HPLC, Leukemia, Daunorubicin and Cytarabine, Linearity and Calibration curve
Design, Formulation and evaluation of sustained release tablet of divelproex sodium
Authors: Kusum , , Gupta Avinash Kumar , Gupta Manish Kumar , Sharma Vijay
Published: September 2024

In the present work, formulation and evaluation of Sustained tablet of Divalproex sodium was carried out. In the project, different formulations of sustained release layer have been prepared. From above formulations best formulation of each sustained release was selected according to the dissolution profile. Divalproex sodium is soluble in 0.1 N NaOH, phosphate buffer pH 6.8, chloroform, methanol, ethanol (95%), and sparingly soluble in water. The absorbance maximum of the Divalproex sodium was found to be at 210 nm when scanned in between 200-400 nm using methanol as well as phosphate buffer pH 6.8 solutions. All the characteristic peaks of Divalproex sodium were present in the spectrum of drug and excipient mixture, indicating compatibility between drug and excipients. In the present work SR tablets of Divalproex sodium were prepared by wet granulation method, using polymer like HPMC K4M for sustained release. Best formulations of was selected for  Divalproex sodium were subjected to hardness, weight variation, friability, drug content uniformity, in vitro drug release and drug polymer interaction.
Keywords: Divalproex sodium, Sustained Release, HPMC and Epilepsy.
A Review on Formulation and Evaluation of Gastroretentive Floating Tablet of Nifedipin
Authors: Jaimini Rohit , Gupta Manish K. , Sharma Vijay
Published: September 2024

Different mass transport processes may occur during drug release from polymer-based matrix tablets, including water imbibition into the system, polymer swelling, drug dissolution, drug diffusion out of the tablet, and polymer dissolution. Depending on the type of drug, polymer and release medium and on the tablet composition, the respective processes are more or less important. Velasco et al.24 reported that the rate and mechanism of nifidipine release from HPMC K15M-based matrices were mainly controlled by the drug/ HPMC ratio, and that drug release was independent of the compression force in the range between 3 and 12 kN. The effects of the two formulation variables ‘‘HPMC/ lactose ratio’’ and ‘‘HPMC viscosity grade’’ on the release of adinazolam mesylate from cylindrical tablets was studied by Sung et al. The resulting drug release rate was found to increase with decreasing ‘‘HPMC/ lactose ratio’’ and decreasing ‘‘HPMC viscosity grade
Keywords: HPMC, Floating tablet, Gastroretentive, Gastric residence.
A Review on Formulation and Evaluation of Sustained Release Tablet of Devilproex Sodium
Authors: Kusum , , Gupta Avinash Kumar , Gupta Manish Kumar , Sharma Vijay
Published: September 2024

An appropriately designed drug delivery system can be a major step towards solving these two problems. This technique for the drug   administration is termed as ‘sustained release’ or ‘controlled release.  Drugs  with  dosage  not  exceeding  125mg  –  325mg  are  more  suited  as  extended  release  products in order to limit the size of the delivery system.   In  the  case  of  soluble  matrix  the  matrix  swells  or  dissolves.  These matrices then undergo surface erosion with little or no bulk erosion. Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. One of its most important characteristics is the high gelation velocity and viscosity, which has a significant effect on the release kinetics of the incorporated drug. It was proven that HPMC at high concentration promoted the drug release approaching to a zero-order release kinetic because of its gelation properties
Keywords: HPMC, Divalproex sodium, sustained release and zero-order release kinetic
Formulation Development and Evaluation of Gastroretentive Delivery System (Microspheres) Using Natural Polymer
Authors: Rai Aastha , Malviya Rajeev Kumar , Patidar Dhanraj , Sharma Krati , Raj Vishnu
Published: September 2024

Microspheres are novel drug delivery approach to control release of pharmacologically active ingredient as per patient need. Natural polymers like fenugreek mucilage are cheap, biodegradable and have been proved safe for pharmaceutical formulation. Higher loading efficiency was observed for all the formulations and also the drug release was observed for the period of 12 hours. Thus, the simvastatin microsphere using fenugreek mucilage showed promising results in retarding the drug release. It can be concluded from whole study that due to the formation of polymeric network system or other active moiety can be easily entrapped with the matrix and hydration and swelling of natural polymer controlled their release pattern
Evaluation of Antimicrobial Profile of Some Novel 1, 3, 4-Oxadiazole Derivatives Followed by Molecular Docking Against 3G7E Bacterial DNA Gyrase
Authors: Bhaumik Asish , Chinna Eswaraiah M. , Chakraborty Raja
Published: September 2024

The main aim and objective of the present research work was the design, synthesis, spectral characterization and evaluation of in vitro antimicrobial profile of some novel oxadiazole derivatives followed by molecular docking studies against bacterial DNA gyrase. The molecular structures of the synthesized compounds were assigned by IR, NMR and Mass spectral analysis. Molecular docking studies were carried out by AUTO DOCK programme. The in vitro antibacterial and antifungal activities were done by paper disk diffusion and agar streak dilution technique. In silico molecular docking studies the binding energy  of synthesized compounds (AB1-AB8)  were found to be  -7.66, -7.67, -7.12, -7.12, -6.59, -6.46, -7.35, -5.09 which indicated that the compound had the high binding affinity towards the  bacterial DNA gyrase with PDB id 3G7E and inhibit the function  topoisomerase in comparison with standard drug ciprofloxacin (-7.44). The preliminary antimicrobial screening displayed that most of the synthesized compounds were executed moderate to good antimicrobial activity against  following bacteria: S. aureus (ATCC 9144), B. subtilis (ATCC 6633), S. epidermidis (ATCC 12228), P. Aeruginosa (ATCC27853), E.coli (ATCC25922), V. cholerrae (ATCC14035) and fungi:  A. Niger (ATCC 9029), A.flavus (ATCC204304), C. albicans (ATCC10231) and B. dermatitis (ATCC 26199) etc. All the synthesized compounds exhibited moderate to good antibacterial and antifungal activity with an MIC range of 12-37µg/ml.  Among these eight synthesized oxadiazole derivatives, compound AB1; AB2 and AB7 were found to be very good antibacterial as well as antifungal potentiality with an MIC range of 13-12 µg/ml; 7-10 µg/ml and 15-18 µg/ml.
Keywords: Molecular docking; NMR; disk diffusion; antibacterial; antifungal and MIC etc.
Formulation and Evaluation of Antifungal Herbal Gel Containing Ethanolic Extract of Senna Alata, Murraya Koenigii and Aloe Vera
Authors: Vishwakarma Shubhangi , Gupta Mansi
Published: September 2024

Herbal medicines is still the mainstay of about 75-80% of the world’s population, mainly in developing countries, for primary health care because of better cultural acceptability, better compatibility with human body and lesser side effects. Herbal medicines consist of plant or its part to treat injuries, disease or illnesses and are used to prevent and treat diseases and ailments or to promote health and healing. it is a drug or preparation made from a plant or plants and used for any to such purpose. The aim of present study was to prepare herbal gel formulation containing ethanolic extract ofantifungal herbal gel containing ethanolic extract of senna alata, murraya koenigi iand aloevera. Topical gel formulation was designed by using ethanolic extract antifungal herbal gel containing ethanolic extract of senna alata, murraya koenigii and aloevera in varied concentrations. The gel was prepared by using carbopol 940(1%w/v),ethanol,propylene glycol, methyl paraben, propyl paraben, edta disodium, tri-ethanolamine and required amount of distilled water. the prepared gels were evaluated for physical appearance, ph, spread ability, drug content, swelling index, diffusion study, viscosity, homogeneity and grittiness. it was inferred from results that gel formulations were good in appearance and homogeneity. Antifungal herbal gel containing ethanolic extract of senna alata, murraya koenigii and aloevera based gel proved to the formula of choice, since it showed the highest percentage of extrudability, good spreadability and rheological properties.
Keywords: Ethanolic extract, Optimization, Rheological properties, Anti fumgal activity.
Preformulation Studies of Intranasal Solid Lipid Nanoparticles of Mometasone Furoate
Authors: Madgulkar Ashwini R , Padalkar Rahul R , Amale Sushant K
Published: September 2024

The objective of the present work was to prepare intranasal solid lipid nanoparticles (SLN) of mometasone furoate. Mometasone furoate is BCS class II drug having low aqueous solubility and highly sensitive to hepatic metabolism. Mometasone furoate loaded nanoparticles were prepared by high pressure homogenization technique. The preformulation studied was conducted by studying various selection criteria. Lipid was chosen on the basis of maximum solubility of the drug in lipid. Glyceryl monostearate was selected as the lipid phase which showed maximum drug solubility than other lipids. Selection of surfactant, homogenization pressure and no. of homogenization cycle was done on the basis of minimum particle size and maximum % entrapment efficiency. These results showed high entrapment efficiency and minimum particle size.
Keywords: Intranasal solid lipid nanoparticles, High pressure homogenization, Glyceryl monostearate.
Ethnobotanical and Medicinal plant study in Trimbkeshwar Taluka, District Nashik, (MS), India
Authors: Sonawane Vitthal B.
Published: September 2024

The present study on ethnobotanical, traditional medicinal plants were conducted different locality of Trimbkeshwar taluka during 2018. The study was focused on identifying medicinal plants, disease treated, method of preparation, part of the plant used etc. The data was collected using interview and questionnaires by traditional healers. A total 40 medicinal plant species belonging to 30 families have been reported as employed by the rural folk and tribals. These ethnomedicinal plants species need obviously further scientific evaluation to have new sources of drugs. So it must be preserved and propagated.
Keywords: indigenous knowledge, ethnobotany, medicinal plants
A Review on Eight System Inspection Model
Authors: Jagatp Sneha R. , Bhusnure Omprakash G.
Published: September 2024

The FDA's Drug Manufacturing Inspection Compliance Program, which constitutes instructions to FDA personnel for conducting inspections, is a systems-based approach for inspections and is very consistent with the robust quality systems model presented in this guidance. The diagram below shows the relationship among the six systems: the quality system and the five manufacturing systems.  The quality system provides the foundation for the manufacturing systems that are linked and function within it. The quality systems model described in this guidance does not treat the five manufacturing systems as discrete entities, but instead integrates them into appropriate sections of the model. Those familiar with the six-system inspection approach will see organizational differences in this guidance; however, the inter-relationship. Generally, the term quality unit is used in this guidance.  However, quality control unit is used when directly quoting parts. United States Food and Drug Administration (USFDA) propose Six System Inspection Model for the audit of pharmaceutical organization for minimization of regulatory submission. Author studied this system, then added and modified this to Eight System Inspection Model to make this more useful and user friendly for the pharmaceutical organization which wants to go for USFDA or other international audits. While doing this author added two additional systems (Management/Regulatory) and four additional points (Validation, HVAC System Validation, Water and Steam System Validation and Vendor Certification).
Formulation and Evaluation of Ginger Extract Loaded Nanoemulgel for the Treatment of Rheumatoid Arthritis
Authors: Chandra Amit , Arya Rajeshwar Kamal Kant , Pal Govind Raj , Tewari Bhawna
Published: September 2024

Ginger is a potent anti-inflammatory; in the present study the nanoemulgel of ginger extract was formulated for treating rheumatoid arthritis through topical application. The main objective of nanoemulgel formulation was to enhance the bioavailability of ginger extract through topical route and also to reduce the dose of ginger extract. First the nanoemulsion was prepared with the help of ternary phase diagram, using water titration method. The Smix (surfactant and co-surfactant) and extract were mixed together then titrated with water. The Smix was used at the ratio of 1:1, 1:2, and 2:1. The isopropyl myristate is used as oil, tween 80 as surfactant, ethanol as co-surfactant and water was used as aqueous phase and, 32 formulations were prepared. The particle size was found in the range of 60.32 to 230.8nm for formulations F1 to F4. The zeta potential was found between -16.6 to -24.4 and the polydispersibility index was found to be 0.687 to 0.892. Nanoemulsion was converted into nanoemulgel by using carbopol 934 as gelling agent in various concentrations. The rheological properties, spreadability, pH, thermodynamic stability and drug release were also determined. On the basis of thermodynamic stability, spreadability and drug release, the nanoemulgel F4* was considered as best formulation.
Keywords: nanoemulgel, nanoemulsion, ternary phase diagram, rheumatoid arthritis, ginger extract, co-surfactant
Synthesis and Characterisation of Starch Glutamate as a Novel Superdisintegrant
Authors: Santosh Kumar Rada , Mudili Sahithi
Published: September 2024

Superdisintegrants have been developed to improve the disintegration process of the fast dissolving tablets. Superdisintegrants acts as structural weakner in fast dissolving tablets and helps in the quick breakup of the tablet into small particles. A new novel superdisintegrant starch glutamate has been synthesized by esterification process and characterized by the FTIR, X-ray diffraction and scanning electron microscopy. Starch glutamate physical and micromeritics properties have been evaluated.The prepared starch glutamate was in soluble in aqueous buffers, organic and in-organic solvents tested. It was free flowing, amorphous in nature, having good swelling index, excellent flow property. The swelling index of starch glutamate was found to be 1200 indicating the suitability of starch glutamate as superdisintegrant in the formulation of fast dissolving dosage forms.
Keywords: Superdisintegrants, Starch glutamate, Swelling index.
FORMULATION AND EVALUATION OF NASAL INSITU GEL OF SUMATRIPTAN SUCCINATE FOR THE TREATMENT OF MIGRAINE
Authors: Aabid P K , Ashwani M.
Published: September 2024

In situ gelling system are better and formulation of time since they have multiple advantages over conventional drug delivery system includes better bioavailability ,retention on the desired site and patient compliance .Nasal drug delivery is a better option to deliver drug across Blood brain barrier and in this research work an attempt was made to prepare insitu temperature triggered nasal gel of Sumatriptan Succinate for the treatment of Migraine .For the preparation of best insitu gel Poloxamer 188 in different concentration was used to formulate insitu gel along with HPMC K4M  .The optimized formulation was chosen after evaluating the prepared gel for pH, Viscosity, Gel strength  and mucoadhesive strength then final optimized formulation was subjected for texture analysis ,in vitro drug release and Differential Scanning Calorimetery and drug release data was also evaluated for Release kinetic of formulation .Formulation batch F5 was selected as best formulation batch because it exhibited best result among all the prepared formulation and proved as promising  temperature triggered formulation of insitu gel.
DEMONSTRATION OF LYMPHATIC UPTAKE OF (6)-GINGEROL SOLID LIPID NANOPARTICLES
Authors: Bhalekar Mangesh R , Madgulkar Ashwini , Jagtap Tejaswini Vikram
Published: September 2024

(6)-Gingerol, a disease modifying anti-rheumatoid drug (DMARD) agent in the treatment of Rheumatoid Arthritis is a potent inhibitor of COX-1, COX-2 activity, inhibits PGE2 production. It also inhibits the production of TNF-α by blocking the cell associated conversion of TNF precursor to mature proteins thus, halting the proliferation of synovitis. (6)-Gingerol undergo extensive phase I metabolism & underlies low systemic exposure. The aim of the present study was to overcome these limitations and formulate and evaluate Ginger extract Solid Lipid Nanoparticles to improve bioavailability by enabling lymphatic uptake. (6)-Gingerol Solid Lipid Nanoparticles were prepared by melt emulsification-homogenization method and the particle size, Zeta potential PDI and % entrapment efficiency was optimized using Box Behnken design. The optimized SLN were found to be 237nm in size, bearing -25.3mv zeta potential, 0.350 PDI and entrapment efficiency of 91.33%.  Ex vivo endocytic uptake studies (everted intestine method) revealed involvement of endocytic pathways in the uptake of Solid Lipid Nanoparticles from intestine. Thus underlining the utility of SLN for enhancement of uptake of (6)-Gingerol.
HEPATITIS INDUCED BY ANTI-TUBERCULAR THERAPY AND CHRONIC ALCOHOLISM: A CASE REPORT
Authors: Bangwal Rohit , Joshi Yogesh , Rawat Jagdish Kumar
Published: September 2024

Anti-tubercular drugs induced hepatotoxicity, which is a serious problem and it was reported that worldwide 2-32% of TB patients experience drug induced hepatotoxicity (DIH) during the course of the treatment. A 65 year old male, 47 kg weight and chronic alcoholic was brought to a tertiary care hospital in semi-conscious condition with chief complains of vomiting, cough with expectoration, loss of appetite, shortness of breath, fever (on & off) since 4 days. He had a history of smear positive pulmonary koch’s 10 days back and was taking regular first line anti-tubercular drug therapy (Isoniazid, Rifampicin, Pyrazinamide and Ethambutol). In this case, the patient was also chronic alcohol consumer and a known case of chronic obstructive pulmonary disease (COPD) since 2 years. After 10 days of anti-tubercular drug therapy, patient was found to develop hepatotoxicity with the findings of elevated total bilirubin and liver enzymes level. Viral markers for hepatitis, including hepatitis B viruses (HBV), hepatitis C viruses (HCV), human immunodeficiency virus (HIV), were all are non-reactive. Physician found provisional diagnosis of anti-tubercular drugs with alcohol induced hepatitis. Patient was on hold of previous anti-tubercular drugs therapy. Although it was started modified anti-tubercular drugs (Streptomycin, Levofloxacin, Ethambutol) therapy along with liver tonics. Upon normalization of patient conditions, physician started first line anti-tubercular drug therapy containing Rifampicin, Isoniazid, Pyrazinamide, Ethambutol and Pyridoxine with continued liver tonics. Routine monitoring of liver enzymes, total bilirubin were followed up till discharged. Such type of case studies with confirmed pulmonary koch’s conditions suggested to follow alcohol withdrawal with standard treatment and standard care to achieve a favorable outcome.
Microplastic pollution in the surface water of Yele Mallappa Shetty Lake, Bengaluru: first report
Authors:   Department of Chemistry, Mount Carmel College, Autonomous, Bengaluru-560 052, India, Kaviyarasi N.S. , Prasanna V. ,   Department of Chemistry, Mount Carmel College, Autonomous, Bengaluru-560 052, India, Abitha S. ,   Kendriya Vidyalaya Sangathan, Bengaluru-560 036, India, Anifowoshe A.T. ,   Department of Developmental Biology and Genetics, Indian Institute of Science, Bengaluru-560 012, India,   Cell Biology and Genetics Unit, Department of Zoology, Faculty of Life Sciences, University of Ilorin, PMB 1515, Ilorin, Nigeria
Published: September 2024

Aim: This study was conducted to identify and characterize microplastics in Yele Mallappa Shetty (YMS) Lake, Bengaluru. Methodology: Water samples were collected from four distinct entry locations to the lake and analysed for microplastic as per the methods adopted by the National Oceanic and Atmospheric Administration (NOAA). Results: Samples of three different microplastic foams—polyester, polyurethane, and polypropylene—were analysed using scanning electron microscopy (SEM), visual analysis, hot needle testing and Raman spectroscopy. The diameters of various components ranged from 0.2-3 mm, with the majority of the samples consisting of fibres (26%), fragments (27%), films (25%) and foam (22%). The mean concentration of microplastic recorded in the water sample was 10±0.7 particles l-1. Interpretation: Protecting wetland ecosystems is essential because they provide countless services, such as food and building materials, biodiversity, flood control, and groundwater recharge. This study provideds valuable baseline data on microplastics in YMS lake for the first time. Key words: Bengaluru lake; Lake water, Microplastic pollution, Water pollution, Yele Mallappa Shetty Lake
Ameliorative extract Syzygium cumini seed extract on lipid peroxidation and antioxidant activity in alloxan induced diabetic Wistar albino rats
Authors:   Department of Zoology, Queen Mary’s College, Chennai -600 004, India, Kavitha E. , Sendhilvadivu M. ,   Department of Zoology, Queen Mary’s College, Chennai -600 004, India
Published: September 2024

Aim: This study intends to examine the protective effects of an aqueous extract of Syzygium cumini seed on lipid peroxidation and antioxidant enzyme activities in alloxan-induced diabetic Wistar albino rats. Methodology: A single intraperitoneal injection of 150 mg kg-1 b.wt of alloxan monohydrate was used to induce diabetes in rats. Syzygium cumini group rats were later administered 300 mg kg-1 of Syzygium cumini seed extract by oral gavage for 21 days. On 22nd day, the animals were given general anaesthesia, blood was drawn through the retroorbital plexus, and the kidneys were promptly removed. Lipid peroxidation levels were assessed in the blood (serum) and kidney tissues by measuring the thiobarbituric acid reactive substances, and the activities of antioxidant enzymes such as GST, GPX, SOD and CAT were examined in the blood and kidneys. Results: The acute toxicity experiments revealed that Syzygium cumini did not cause any obvious toxicity indications or mortality at a dosage of 300 mg kg-1, proving the safety of this extract with a broad therapeutic index. The results obtained showed that using aqueous Syzygium cumini seed extract for 21 days considerably (P <0.05) increased the antioxidant enzyme activity for GST, GPx, SOD and CAT, while significantly (P <0.01) decreasing the TBARS levels. Interpretation: Conclusively, the seed extract of Syzygium cumini might be a possible treatment for controlling hyperglycemic oxidative stress complications owing to its antioxidant properties. Key words: Albino rats, Antioxidant enzymes, Lipid peroxidation, Syzygium cumini, Seed extract
¿Mpox es la nueva enfermedad emergente de trasmisión sexual?
Authors: Jaramillo-Hernández Dumar Alexander
Published: September 2024

Al respecto del reporte #35 del brote multi-países de Mpox, generado el 12 de agosto de este año por la Organización Mundial de la Salud (OMS, 2024), donde se recogen datos epidemiológicos de esta enfermedad emergente de origen zoonótico, que describen desde el 01 de enero 2022 hasta el 30 de junio 2024 el comportamiento de esta enfermedad en la población. Se tienen 99.176 casos confirmados de Mpox y 208 muertes distribuidas en 116 países. Así mismo, de acuerdo a la evaluación de riesgos a largo plazo de Mpox hasta agosto de 2024, el riesgo es ALTO para la República Democrática del Congo (RDC) y países vecinos, que afecta principalmente a adultos y se propaga predominantemente a través del contacto sexual (vinculado al clado Ib). Igualmente, ALTO para RDC donde la mpox es endémica, afecta principalmente a niños y se propaga a través de múltiples modos de transmisión (vinculada al clado Ia). Riesgo MODERADO para Nigeria y países de África occidental, central y oriental donde la mpox es endémica, afecta a niños y adultos y se propaga a través de múltiples modos de transmisión (vinculada a los clados I y II). Riesgo MODERADO para los países de África y de todo el mundo, donde los brotes afectan principalmente a hombres que tienen relaciones sexuales con hombres y se propagan predominantemente a través del contacto sexual (vinculado al clado IIb).
Avoidable Injuries in 1,211 Patients with Dermatological Diagnoses in Claims to the Swedish National Patient Insurance Company during 2016 to 2020
Authors: Tryfonos Korina , Gustafson Pelle , Nyberg Filippa
Published: September 2024

Abstract is missing (Short communication)
Attitudes towards Assessment and Management of Chronic Pain amongst Clinicians at a Tertiary Care Facility, Kenya
Authors: S Rop
Published: September 2024

Background: Chronic pain being a common medical condition seen by clinicians has a significant socio economic and health burden to clients, clinicians and the health institution. Patients with chronic pain presents with limited activities and participation restrictions affecting their quality of life. Previous studies have shown clinician’s negative attitudes towards management of chronic pain. Objective: To determine, attitudes of clinicians towards assessment and management of patients with chronic pain in a tertiary hospital in Kenya. Methods: This was a descriptive cross-sectional study designed to utilize a quantitative approach, a questionnaire containing 77 items was used to collect data, this study adopted census method of sampling because of the small number of the study population (n=240). A total of 153 clinicians volunteered to participate in the study. Data was analyzed using Statistical package for social sciences (SPSS) Version 24. Descriptive statistics was calculated and presented in summary tables and bar graphs. Chi-Square test was calculated to determine the association between sociodemographic characteristics and level of knowledge, attitudes and practice. The statistical significant was accepted at P – value less than 0.05. Results: The response rate was 83.3% (n=153). Only 9% (n= 14) of the respondents believed to have positive attitudes. While 62% (n=95) had negative attitudes on cognitive/behavioral management of chronic pain. Few participants (9% n=14) had positive attitudes in assessment and measurement of chronic pain. Conclusion: The current study supports the concern about negative attitudes and poor practices among clinicians in tertiary healthcare institution. We believe that continuous medical educational on chronic pain, adopting chronic pain guidelines, and research on pain curriculum in medical training institutions are needed to improve clinician’s knowledge, attitudes and practices which may result to better chronic pain outcome.
The Role and Persistence of Islamic Boarding School Teachers
Authors: Subarno Anton
Published: September 2024

The Indonesian government is responsible for the education of children up to grade nine under the age of 18. The government organizes open junior high schools (SMPT) to educate children who cannot attend due to economic and geographical reasons. SMPT is implemented in disadvantaged areas through Islamic Boarding Schools (PonPes). The role and persistence of teachers at PonPes arehas yet to be discovered and appreciated as professional teachers. This research aims to analyze the role and persistence of Islamic boarding school teachers. This research is a qualitative method with an ethnographic approach. This research aims to determine the role and persistence of teachers at PonPes. Teachers, school officials, school committees, tutors, parents and school principals were involved in this research. The subjects involved in this research as key informants were school principals. Purposive snowball sampling was used to select relevant informants and data sources. Source triangulation and method triangulation were used to validate the data. Data analysis refers to the interactive data analysis model from Milles and Huberman. The research results show that teachers have three roles: character builder, diversity teacher, and encourager of students. The persistence of IBS teachers can be seen from the teachers' efforts to understand the culture and demographic characteristics of students, which can manifest in the form of behaviour as coordinators, administrators and motivators. The research implications show that teachers serve parents and students who need school information.
Stock and Sauce Teaching Materials for European Culinary Courses: Vocational Education
Authors: Cokorda Istri Raka Marsiti  , Ni Wayan Sukerti  , Luh Masdarini  , Made Diah Angendari
Published: September 2024

This research is motivated by learning less effective activities because educators must provide detailed information while teaching materials could be more supportive. In addition, the lack of teaching materials will make it difficult for students to carry out learning activities outside of learning hours. The research aimed to develop learning materials related to broth and sauce in European culinary courses. The study used a research and development design adapted to the ADDIE model (analysis, design, development, implementation, and evaluation). The subjects involved in this study were third-semester students of the Tata Boga study program selected by total sampling because the number of students was less than 100. The data collection methods used were document analysis, observation, interview, and questionnaire distribution. Then, the data were analyzed quantitatively and qualitatively. The research findings show that the learning materials developed as e-modules cover students' attitudes, cognition, and skills. The developed product is very feasible and has positive student responses.
A contribuição das âncoras de carreira para o planejamento e o desenvolvimento da carreira profissional de estudantes e egressos de um curso de administração
Authors: Rodrigues Henrique Geraldo , Felice Carolina Camargo , Oliveira Márcia Freire de
Published: September 2024

Por meio de um estudo qualitativo básico, objetivou-se examinar como a compreensão das próprias âncoras de carreira tomou parte no processo de planejamento e desenvolvimento da carreira profissional de estudantes e egressos de um curso de Administração, de uma universidade pública federal. Os resultados mostram que a identificação das próprias âncoras contribuiu à aquisição de autoconhecimento acerca das preferências profissionais individuais, bem como ao estabelecimento de objetivos profissionais e pessoais, e de planos de ações. Também, permitiu a aquisição de autoconfiança em relação às escolhas profissionais, mediante a determinação de parâmetros individuais para as tomadas de decisões profissionais.
Perspectivas socioemocionais em processos de sucessão em empresas familiares de produção rural
Authors: Basani Aline , Sabino Marco Antonio da Costa , Santos Siméia de Azevedo
Published: September 2024

A partir do contexto das empresas familiares que se encontram no ambiente rural, esta pesquisa objetiva identificar como aspectos socioemocionais influenciam o processo sucessório nas empresas familiares, propondo medidas que contribuam para o processo de sucessão com ações de governança familiar. A pesquisa é qualitativa, com estudo de caso, entrevistas em profundidade, e análise de conteúdo por codificação de subcategorias que emergiram do campo. Nos resultados, sucessão deve estar na pauta estratégica das empresas familiares; incidentes críticos podem impor movimentos não planejados; influência da matriarca; preocupação em empobrecer. Além disso, governança é vista como facilitadora, mas incipiente no ambiente das empresas familiares.
A carreira do trabalhador mais velho: uma revisão sistemática da literatura e futuras direções de pesquisa
Authors: Dias Emerson Weslei , Hanashiro Darcy Mitiko Mori
Published: September 2024

Carreira de trabalhadores mais velhos é uma temática pouco investigada tanto na literatura internacional como na brasileira. O objetivo deste artigo é mapear, analisar e sintetizar a publicação científica internacional sobre a carreira destes trabalhadores. Foram revisados 43 estudos das bases Web of Science e Scopus. Essa revisão gerou quatro categorias: trilha da carreira longeva, fatores individuais, fatores organizacionais e políticas públicas e abordagens teóricas. Os resultados contribuem para o avanço da literatura sobre a carreira de trabalhadores mais velhos. Destaca-se uma agenda de estudos futuros que poderá direcionar as investigações, expandindo o conhecimento científico sobre longevidade de carreira.
Web-Based Movie Recommendation System Using Content-Based Filtering and Cosine Similarity
Authors: Meillano Zico Fachreza , Richasdy Donni , Hasmawati Hasmawati
Published: September 2024

Movie are one of the most popular entertainment media among people and are often chosen as activities during weekend holidays. As time goes by, world cinema continues to develop with various interesting and entertaining genres, stories and visuals. Because film is one of the entertainment media that can relieve stress from work assignments or lectures and now film production is also growing so that more and more films are being produced until finally people are confused about choosing the film they will watch. To resolve the obstacles faced, movie information is needed that can help people find movies that suit user preferences, so users need a system that can recommend movies. In this research, the author used the content-based filtering method to find movie recommendations. The substance utilizedis the movie genre. The Check Vectorization calculation is utilized to discover the term/word weight values in each record and after that these values are utilized as factors within the Cosine closeness to discover similitudes between archives.As a result of this last project the system can generate a kind of recommendations for the 10 most similar movies. The test results from this final project are that the system is running well and is reliable with an alpha test result of 100%, and a reliability test result of 0.7.
Training Evaluation Analysis Using Text Mining
Authors: Nainunis Mas Akhmad , Yuadi Imam
Published: September 2024

Training evaluation is an evaluation of the results of training that has been carried out. This evaluation includes technical and non-technical factors which are very important for the company to pay attention to when implementing training in the future. Many companies only implement training evaluations as a formality and only include evaluations that are limited by choice, such as closed questionnaires, training evaluations using open questionnaires can provide the freedom to provide positive or negative input that can be of concern to the company. This research aims to find out the words or topics that appear most frequently in open comments on training evaluation results by using the FP Growth algorithm and association rules to find out the relationship between topics or words from the training evaluation results. They are applied to 516 open-ended comments submitted via the post-training questionnaire. The research results showed that 15 association rules were created using Rapidminer using the FP-Growth algorithm with a minimum support of 0.02 and a minimum confidence of 0.5. All rules have a lift value>1 which indicates that all rules are valid or have a strong association relationship. This research can determine the pattern of comments or suggestions given by workers regarding training evaluation.
Recognition of Hijaiyah Letter Patterns Using The Bidirectional Associative Memory Method
Authors: Jarti Nanda , Rizki Sestri Novia
Published: September 2024

Artificial Intelligence has a very broad scope so it can solve very complex problems. Hijaiyah letter pattern recognition using the Bidirectional Associative Memory (BAM) method has the ability to detect maximum results for the blind who are learning to recognize hijaiyah letters in producing information using a bipolar system. The problem in this research is the difficulty for blind people in recognizing hijaiyah letters and patterns, so this research was designed to help blind people learn hijaiyah letters so that they can easily understand the patterns and types of letters using the 3x3 order matrix concept. In the BAM has the advantage of layers that are interconnected between one layer and another layer so that they can be connected from the input layer to the output layer. This research will produce a Hijaiyah letter recognition pattern using the 3x3 Matrix system to design a system for identifying Hijaiyah letter patterns. From the results of the tests that have been carried out, there are 5 Hijaiyah letter patterns, namely ا, ث, ج, ذ and ش which are processed by pattern recognition with a value of 1. [1.1] [1,-13],[-1,1][3,-11 ],[1,-1] [-9,-17],] [-1,1][ [13,9], [-1,1][-13,13]. Of the 5 Hijaiyah letter patterns, only 2 letter patterns were able to be recognized by the system, namely the letters ذ and ش, and 3 patterns were not able to be recognized by the system. Thus it can be concluded that not all patterns using the BAM method are able to recognize patterns precisely and correctly.
Sentiment Analysis Towards the Film Dirty Vote on Twitter Social Media Using the K-Nearest Neighbor Algorithm
Authors: Fadillah Annisa , Sriani Sriani
Published: September 2024

The appearance of the dirty vote film has received public attention and went viral on social media after being released and watched by millions of people in a short time. The dirty vote film has become a topic of discussion, one of which is on the social media platform Twitter. This research was conducted to determine the views or tendencies of public opinion regarding dirty vote films on Twitter social media using K-Nearest Neighbor which will be classified into positive, neutral and negative sentiment. The sentiment data that was collected in the data crawling process was 4000 pieces of data. Then after preprocessing there were 3978 data. Labeling was carried out using text blob, it was found that the negative sentiment class was 3470 superior to the positive sentiment class of 451 and the neutral sentiment class was 57. The 10-fold cross validation test produced an average accuracy value of 87.5%. Testing was carried out with 80% training data consisting of 3182 data and 20% test data consisting of 796 test data. The results of sentiment analysis show that the K-Nearest Neighbor method can be used for sentiment analysis. The accuracy value obtained was 87%, precision was 87%, recall was 100%, and f1-score was 93%.