bluuebunny/crossref_metadata_2025 huggingface dataset:
Seasonal distribution of Calliphoridae and Mesenbrinellidae (Diptera) associated with the decomposition of a clothed animal model in a forest reserve in the Central Amazon
Authors: de Souza Alex Sandro Barros , Agra Daniela , Martins Renato Tavares , Gomes Patrícia Pereira , Ferreira-Keppler Ruth Leila
Published: July 2023

We evaluated the effects of seasonality on the richness and abundance of dipterans of the families Calliphoridae and Mesembrinellidae associated with the decomposition of a clothed Large White swine Sus scrofa domesticus(Artiodactyla: Suidae) carcass. Experiments were carried out in less rainy, rainy, and intermediate periods between 2010 and 2011 at Reserva Florestal Ducke, Manaus, Amazonas. Two pig carcasses, each weighing approximately 40 kg, were used in each period. A total of 63,872 individuals of 18 species of Calliphoridae and Mesembrinellidae were collected. The abundance and richness of these dipteran families were influenced by the interaction between period and decomposition stage. The compositions of the Calliphoridae and Mesembrinellidae assemblages differed among periods, with the fauna of the less rainy period being less similar to those of the intermediate and rainy periods than they were to each other. Three species were selected as indicators for the less rainy period, namely Paralucilia pseudolyrcea (Mello, 1969) (Diptera, Calliphoridae), Paralucilia nigrofacialis (Mello, 1969) (Diptera, Calliphoridae), and Eumesembrinella randa (Walker, 1849) (Diptera,Mesembrinellidae) while Chloroprocta idioidea (Robineau-Desvoidy, 1830) (Dipetra, Calliphoridae) was selected as an indicator species for the rainy period; no taxon was selected as an indicator of the intermediate period. Among decomposition stages, only fermentation and black putrefaction had indicator taxa, with Hemilucilia souzalopesi Mello, 1972 (Diptera, Calliphoridae and Chysomya putoria(Wiedemann, 1830) (Diptera, Calliphoridae), respectively. Clothes did not prevent the laying of eggs and became a kind of protection for immature stages. The clothed model presented a delay in decomposition compared to other studies developed in the Amazon region.
From Dadaab Camp to Kismayo City: A Call for Local Evidence to Inform Durable Solutions
Authors: Mohn Charlotte , Tonnarelli Francesco , Weaver Jonathan , Njuguna Winston , Barkhadle Abdirahman
Published: July 2023

These field reflections contribute to the discussion on durable solutions to displacement by providing empirical evidence of how intended spillover effects of carefully designed interventions and hybrid settlements can facilitate local integration and return and reintegration. A comparison between Dadaab and Kismayo reveals humanitarian and development aid’s influence and spillover effects on economic, social, cultural, and political life beyond the borders of refugee camps and returnee settlements. We argue for leveraging such spillover—in particular in the form of hybrid settlements—for achieving durable solutions to displacement cost-effectively and inclusively. Our observations show that several local stakeholders have recognized the potential of spillover, too and are actively embracing it to drive local socio-economic development. Lastly, we highlight the need for further research into the factors that enable or prevent spillover effects and hybrid settlements from reaching their full potential: the achievement of durable solutions for displacement-affected communities.
‘My Family Needed Me’: Exploring Caring Dimensions and Care Circulation among Older Venezuelans on the Move in Peru
Authors: Blouin Cécile , Borios Stéphanie
Published: July 2023

The humanitarian, political, and socio-economic crisis in Venezuela has generated an unprecedented migration to other South American countries. In the last six years, Peru has become the second receptor of Venezuelan people after Colombia and the first regarding asylum seekers. In this article, we follow recent contributions regarding the concept of care circulation to ask: how the case of older Venezuelans on the move illustrates the multidimensionality of care circulation? How these care arrangements can be understood from an age and gender perspective? Through three life stories, we discuss how older Venezuelans on the move practice care for the benefit of the whole family based on family arrangements and negotiations and how, as a result, care circulates in multiple directions and can generate conflicts and power imbalance for the older ones.
(110) EXTRACELLULAR VESICLES ISOLATED FROM PEYRONIE’S DISEASE-DERIVED CELLS CAN ALTER TGF-BETA 1 SIGNALLING CASCADES
Authors: Dr. Marcus M Ilg , Prof. David J Ralph , Prof. Selim Cellek
Published: July 2023

Objectives

The importance of extracellular vesicles (EVs) as key mediators of cell-cell communication has been highlighted in recent years. However, their role in the pathophysiology of Peyronie’s disease (PD) and other fibrotic disorders is still unclear. Fibroblasts and myofibroblasts are key effectors in PD and this study seeks to further elucidate a previously described role of EVs in myofibroblast transformation in PD.

Methods

Primary fibroblasts were isolated from tunica albuginea of PD patients. Cells were cultured in DMEM with 10% Knockout Serum Replacement and EVs were isolated from the conditioned media in presence and absence of transforming growth factor beta 1 (TGF-β1). Isolation of the EVs was performed using ultrafiltration with subsequent size exclusion chromatography. Fibroblast and myofibroblast transcriptome was analysed using Nanostring nCounter. Classical EV markers were confirmed using Western blot. EV quantity, size, and shape was analysed using Tunable resistive pulse sensing (TRPS). Expression of α-smooth muscle actin (α-SMA), pSmad2/3 and pErk1/2 in presence and absence of TGF-β1 was assessed using In-Cell ELISA (ICE).

Results

Myofibroblasts produced more EVs and smaller EVs than fibroblasts and classical EV marker expression was confirmed. Nanostring nCounter revealed that fatty acid metabolism, cholesterol metabolism, and de novo lipogenesis were differentially regulated in cells treated with TGF-β1, in line with increased EV production. Myofibroblast EVs prevented TGF-β1-induced myofibroblast transformation which could be prevented with an inhibitor of vesicle uptake (10 μM dynasore). Myofibroblast-derived EVs but not fibroblast-derived EVs were able to affect downstream effectors of TGF-β1, by preventing the phosphorylation of pErk1/2. No effect on pSmad2/3 phosphorylation was observed.

Conclusions

This is the first study to demonstrate that PD-cell-derived EVs can affect signalling cascades downstream of TGF-β1. Only non-canonical TGF-β1 signalling is influenced and the effect appears dependent on cellular uptake of the vesicles. Further study is needed to decipher the cargo responsible for this effect.

Conflicts of Interest

This study is partly funded by ESSM Research Grant (ESSM RG-19 04).
(137) PENILE LENGTH BEFORE AND AFTER THE IMPLANTATION OF AN INFLATABLE PENILE PROSTHESIS
Authors: Dr. Cedric Jorissen , Dr. Andries Van Huele , Prof. Koenraad van Renterghem
Published: July 2023

Objectives

There is a high satisfaction rate after implantation of an Inflatable Penile Prosthesis (IPP) for patients with erectile dysfunction (ED). The postoperative length of the penis is a factor that can negatively affect this. Therefore, it is important to create realistic expectations. We aim to evaluate the difference in length before and after surgery.

Methods

We analysed data derived from the ongoing PHOENIX trial. Ethics committee registration number B243201940514. We included 100 patients who were operated from 11-2021 to 09-2022, in a single centre by a single surgeon. Only virgin implants were included. Penile length was measured in a standardized way in the flaccid and stretched state preoperatively. After surgery, the length was measured again in deflated and inflated state.

Results

Included patients had a mean age of 61 years. A Coloplast Titan prosthesis was used in 51 patients, an AMS CX prosthesis in 46 patients and an AMS LGX in 3 patients. The mean length of the cylinders was 19.57cm. The average length of the penis after implantation was 7.98cm deflated and 8.36cm inflated. The mean difference in length after implantation between deflated and inflated was 0.3cm. Sub analyses of this parameter to compare the Coloplast and AMS group showed no significant difference (0.26cm vs. 0.48cm respectively). After implantation, the length of the inflated state was on average in all patients, 3.3cm longer than the flaccid state preoperatively, compared to only 0.07cm longer than the stretched state preoperatively. For this also no significant difference between the Coloplast and AMS group.

Conclusions

The stretched penile length preoperatively gives a good estimate of the expected length postoperatively and can be used to give patients a realistic expectation. When the prosthesis is inflated, there is no significant increase in length compared to the deflated state. We found no difference between Coloplast Titan and AMS.

Conflicts of Interest

No conflict of interest.
(267) ERECTILE DYSFUNCTION TREATMENT WITH RADIOFREQUENCY ENERGY-BASED DEVICE RF VERTICA®, 6-MONTH FOLLOW-UP
Authors: Dr. Sergiu Bistritzky , Dr. Boaz Appel , Dr. Arik Shechter , Prof. Ilan Gruenwald
Published: July 2023

Objectives

A recent study of a new radiofrequency-based device (RF Vertica®) in treating Erectile Dysfunction (ED) showed promising results, safety, and satisfaction. However, there are no data on long-term follow-up. We aim to assess 1,3, and 6-months follow-up efficacy based on IIEF-EF and EHS questionnaires.

Methods

Follow-up data assessment of men included in RF energy treatment of ED pilot study. ED was evaluated before the treatment, 1-, 3-, and 6-months following all treatment sessions, using IIEF-EF, Erection Hardness Scale (EHS). Questions addressing side effects and ease of use were also evaluated.

Results

Twenty-seven out of 28 men with ED (mean age 59.5.7±9.8, range: 42-77) completed 1,3, and 6-month follow-ups after concluding all treatment sessions. Mean IIEF-EF and EHS scores significantly improved after ending treatment compared with baseline values, and the treatment was still effective at 3- and 6-months follow-up.

Patients didn't report any difficulties in using the device, and no side effects.

Conclusions

RF Vertica® device is an effective, safe, and easy-to-use method in treating ED. Patients report good treatment response at 1,3-and 6-months follow-ups. There is a need for additional studies with a more significant number of men and longer follow-ups to assess the long-term effects of the treatment.

Conflicts of Interest

Professor Ilan Gruenwald, MD, is a medical consultant at Vertica-Labs company.
(120) PENOSCROTAL DECOMPRESSION SHOULD BE CONSIDERED FOR PROLONGED ISCHEMIC PRIAPISM
Authors: Gin Lee Wai , Dr. Shafi Wardak , Prof. David Ralph
Published: July 2023

Objectives

Outcomes of men with prolonged ischemic priapism (PIP) are poor. Management includes a proximal corporal shunt or immediate penile prosthesis placement with an increased risk of erosion and infection. Penoscrotal decompression (PSD) relieves the acute compartment syndrome of PIP and restores perfusion but experience is limited to 31 cases from North America.

Methods

Retrospective review of men presenting with ischemic priapism confirmed by cavernosal blood gas and biopsy at time of decompression. Duration of ischemia, prior management, clinical outcomes and change in International Index of Erectile Function (IIEF) score were analyzed.

Results

Thirteen patients with a median duration of PIP of 48 hours (IQR 38-56) presented between 2019-2022. Etiology of PIP was idiopathic in 5, iatrogenic or recreational drug-related in 6 and sickle-cell disease (SCD) in 2 men. All failed intracavernosal phenylephrine and 2 failed distal corporo-glanular shunting. All had successful detumescence with 9 (69%) requiring bilateral PSD. Immediate pain relief was achieved in all but one. Another patient with SCD recurred within 24 hours following unilateral PSD that resolved with intracavernosal phenylephrine. Only one man without SCD developed a recurrence of priapism the next day and he proceeded to insertion of a malleable penile prosthesis on day 2. There was no association between unilateral PSD and recurrence. IIEF scores fell by a median of 12 (IQR 2.25-15.5) and 6 men developed refractory erectile dysfunction after median follow-up of 17.6 months (IQR 1.3 – 19.7).

Conclusions

In the first study outside of North America, PSD successfully relieved PIP in all patients with good pain relief for most (n=12, 92%). Six men developed refractory erectile dysfunction while 3 had recurrent priapism due to SCD (n=2) and cocaine abuse (n=1). The lack of fresh corporal bleeding following PSD is a risk factor for failure and an immediate penile prosthesis should be considered. PSD averted the need for penile prosthesis insertion in 54% of men.

Conflicts of Interest

Nil
(130) INGUINAL LYMPHADENECTOMY FOR PENILE CANCER: RESULTS OF A PROSPECTIVE RANDOMIZED TRIAL COMPARING OPEN VS VIDEO LAPAROSCOPIC APPROACH
Authors: Marco Falcone , Dr. Mirko Preto , Dr. Marco Oderda , Dr. Federica Peretti , Dr. Lorenzo Cirigliano , Dr. Ilaria Ferro , Dr. Natalia Plamadeala , Dr. Carlo Ceruti , Prof. Paolo Gontero
Published: July 2023

Objectives

To compare surgical and oncological outcomes between video laparoscopic (VEIL) and open inguinal lymphadenectomy (OIL) in patients affected by locally advanced penile cancer (PC).

Methods

Prospective randomized trial including patients underwent staging or radical inguinal lymphadenectomy for PC from October 2019 to March 2022. Patients were randomized to receive OIL on one groin and VEIL on the contralateral side. Operative time, intra and post-operative complication rate (according to Clavien-Dindo classification), number of removed and positive lymph nodes, disease-free survival (DFS) and overall survival (OS) were collected, compared and analyzed during the follow-up period.

Results

28 inguinal lymphadenectomy procedures satisfied the inclusion and exclusion criteria, 14 (50%) OIL and 14 (50%) VEIL. Median follow-up was 14 months (IQR 6-17). No significant differences in terms of operative times, number of removed lymph nodes, 1-year DFS and 1-year OS were recorded in-between the two surgical approaches. Time to drainage removal was significantly shorter in the VEIL group (15days; IQR 13-17) than in the OIL group (27days; IQR 20-41; p <0.05). No intraoperative complications occurred. Long-term postoperative complications were recorded in 3 (21.4%) and in 8 (57.1%) groins respectively in the VEIL and in the OIL group (p <0.05). In the follow-up period, 2 patients died for PC.

Conclusions

VEIL may reduce postoperative complications when compared to OILL. Further high-powered studies are warranted to confirm these preliminary results.

Conflicts of Interest

None to declare.
(222) THE NEW PENIS SCORING CRITERIA AND PACKAGE CHECKLIST: RESULTS OF A LITERATURE SYSTEMATIC REVIEW OF PENILE AMPUTATION AND REPLANTATION
Authors: Prof Bruno Machado , Aimee Tran , Dr. Nickolas Scherzer , Scott Bailey , Prof. Wayne Hellstrom
Published: July 2023

Objectives

This study has 3 aims: 1) Produce an updated systematic review of penile replantation 2) Appraise the comparative value of the PENIS Score and propose the PACKAGE Checklist for penile amputation case reports and reviews 3) Identify confusing terminology and recommend standardizing vocabulary to describe penile amputation and replantation.

Methods

We assessed 432 full-text case reports in 20 languages identifying 122 microsurgical and 40 surgical cases of penile replantation that qualified for our review. The cases were stratified using the PENIS Score for penile amputations using five criteria: position, extension, neurovascular repair, ischemia time and type, and severed edges and contamination. Four outcomes: postoperative complications, erection, urination, and sensation, were evaluated using Kendall’s tau coefficient for each of the PENIS criteria.

Results

The viability of microsurgical and surgical replantation was equivalent at 92% and 94%, respectively. A statistical correlation was found between microsurgical repair and the return of sensation, though this did not correlate with nerve repair. The return of sensation with nerve repair was 51%, comparable to microsurgical replantation without nerve repair at 42%, both were significantly higher than the 14% found in surgical replantation. A significant correlation was noted between the extension of the amputation and the severity of postoperative complications in microsurgical replantations, (τ = .2649, p = .0126), not observed with surgical replantation. the presence of a skin bridge was associated with a 40% reduction in severe postoperative complications compared to complete amputations, regardless of surgical method.

Conclusions

Microsurgical replantation is superior in the return of sensation, with or without nerve repair. In the absence of microsurgical skills, surgical replantation is an appropriate alternative. The lack of standardization in penile replantation case reports makes the comparison between case-reports difficult. Implementing the PACKAGE Checklist and PENIS Score will help future case reports and systematic reviews, allowing for more robust conclusions.

Conflicts of Interest

Authors do not have conflict of interest.
(153) ORGASMIC FUNCTION WORSENING COULD LEAD TO ERECTILE FUNCTION DECREASE AFTER HOLEP – RESULTS FROM A PROSPECTIVE TRIAL (ExpHo)
Authors: Dr. Paolo Capogrosso , Prof. Andrea Salonia , Dr. Giuseppe Fallara , Dr. Edoardo Pozzi , Dr. Eugenio Ventimglia , Dr. Nicolò Schifano , Dr. Federico Belladelli , Dr. Alessandro Bertini , Dr. Luigi Candela , Prof. Francesco Lanzaro , Dr. Federico Dehò , Francesco Montorsi
Published: July 2023

Objectives

Holmium laser enucleation enucleation of the prostate (HoLEP) has been associated with a low risk of erectile dysfunction (ED). We investigated factors associated with risk of erectile function (EF) worsening after surgery for men with normal pre-operative EF

Methods

The ExpHo trial (NCT03583034) is a prospective study collecting data of consecutive patients treated with HoLEP by one highly-experienced surgeon (>1500 cases), at a single centre. All patients completed the International Index of Erectile Function (IIEF) at baseline and those with normal IIEF-EF (>26) were considered for this analysis. Patients have been re-assessed at 1 week, and at 1, 3, 6 and 12 months throughout the follow-up (FU). Kaplan Meier analysis investigated the risk of EF decrease over time. Cox-regression model tested predictors of post-operative EF worsening

Results

Of 242 patients, 66 reported normal IIEF-EF before surgery. Baseline median (IQR) age was 65 (60-70) years and prostate volume (PV) was 75 (58-100) mL. Median pre-operative IIEF-orgasmic function (OF) was 10 (7-10). Median follow-up was 6(1-12) months. At Kaplan-Meier analysis, estimated rates of EF impairment depicted an increase over time, with 12%(95%CI: 6,25) and 19%(95%CI: 11,33) of patients with normal pre-operative EF reporting a post-operative worsening at 3 and 6 months, respectively. Median IIEF-EF score decrease was 4 (2-11). At cox regression analysis, baseline factors (i.e., age, BMI, Charlson Comorbidiy Index, PV, IPSS) and intraoperative factors (i.e., total energy used, capsule perforation) were not associated with EF decrease over time (all p>0.6). Conversely, patients experiencing a post-operative decrease of IIEF-OF were at higher risk of reporting IIEF-EF worsening (IIEF-OF: HR 0.81; 95%CI: 0.59, 0.94; p=0.009) (Figure 1)

Conclusions

Sexually active patients with normal pre-operative sexual function may experience a non-negligible EF worsening after HoLEP, which appears associated with post-operative OF decrease, thus suggesting that the impairment of antegrade ejaculation could play a major influence in post-HoLEP sexual function.

Conflicts of Interest

NA
(181) APPLICATION OF A VERY LOW CALORIES KETOGENIC DIET (VLCKD) PROTOCOL IN WOMEN'S ENDOCRINOLOGY: PSYCHOSEXUAL CORRELATES OF WEIGHT LOSS
Authors: Dr. Elisa Maseroli , Dr. Sarah Cipriani , Prof. Linda Vignozzi , Dr. Serena Ravelli
Published: July 2023

Objectives

To evaluate the psychosexual correlates of obesity and the Metabolic Syndrome (MetS) in a large sample of women consulting for sexual symptoms; to investigate the change in measures of arousal after weight loss obtained with Very Low Calories Ketogenic Diet (VLCKD).

Methods

In a retrospective study, n=322 women consulting for sexual symptoms were enrolled. The patients underwent a clinical, laboratory, sexual and psychometric examination and were studied by color-Doppler ultrasound with measurement of the Pulsatility Index (PI) of the clitoral artery. Twelve patients underwent a lifestyle intervention based on a VLCKD protocol and compared with patients treated with different strategies for sexual symptoms, in a 1: 1 case-control study.

Results

Clitoral PI was significantly higher in obese women (p = 0.018) and in those diagnosed with MetS (p=0.043). A statistically significant inverse correlation emerged between WC ≥ 88 cm and FSFI Arousal score (R=-0.126, p=0.028). In patients undergoing a lifetsyle intervention (n = 12), after a mean follow-up of 20±2 weeks, BMI showed a reduction of 6.7±2.8 kg/m2 (p <0.001). At follow-up, the total FSFI and FSDS-R scores significantly improved (17.0±13.6 vs. 11.2±7.9, p=0.016, and 7.4±8.3 vs. 13.3±10.6, p=0.039, respectively). A significant increase was observed in FSFI Arousal (p=0.035), whereas clitoral PI displayed a non-significant reduction (p = 0.218). At multivariate analysis, the change in Total FSFI was correlated with the improvement in Body Image (BUT-B PSDI score: β=0.744, p=0.031; Eating Disorder Evaluation “Shape” domain: β=0.523, p=0.043), after adjusting for confounders. Finally, in the case-control study (subjects matched for age, BMI and menopausal state), the improvement in FSFI total score was more relevant in cases than in controls (p = 0.046).

Conclusions

Our data suggest that weight loss obtained by VLCKD is associated with an improvement in sexual function, and in particular in Arousal, which could be mediated by improved body image.

Conflicts of Interest

LV received scientific research grants, advisory board attendance and speaker honoraria from Therascience, Theramex, Bayer Schering Pharma, Intercept, Lipocine, Ibsa. EM and SC have nothing to declare.
(280) THE INTERPLAY OF SEXUAL DISTRESS AND SEXUAL PLEASURE: THE POTENTIAL OF VIBROTACTILE DEVICES TO FOSTER SEXUAL WELLBEING OF BREAST CANCER SURVIVORS
Authors: Magdalena S Große-Rüschkamp , Selina M Kronthaler , Iron J Hahn , Prof. Klaus M Beier , Laura Hatzler
Published: July 2023

Objectives

Breast cancer is the most common cancer in women. The severe impairment of sexual function affecting more than 80% of breast cancer survivors (BCS) is associated with sexual distress, poor mental health, and body image. The biological mechanisms of chemotherapy and endocrine therapy leading to vulvovaginal atrophy are well understood. Guidelines recommend the usage of lubricants and devices like vibrators to overcome these physical impairments. However, data on the impact of sexual distress on genital arousal and the experience of sexual pleasure is limited. The aim of this study is to provide evidence on the interplay of sexual distress and sexual pleasure during the use of vibrotactile stimulation.

Methods

In a psychophysiology lab setting BCS (n=40) and healthy controls (HC, n=20) use sexual stimuli (visual, tactile, visual + tactile) while subjective arousal, vaginal pulse amplitude (VPA) and heart rate variability are recorded continuously. Hormone serum levels, patient reported outcome measures (PROMs) assessing sexual function, sexual self-esteem, and health related quality of life are analyzed as potential moderators.

Results

Preliminary results of healthy participants indicate that vibrotactile stimuli provoke higher VPA in HC. Furthermore, i.) differences between BCS and HC, ii) interactions of PROMs and continuously recorded measures and iii.) intraindividual differences between different stimulus conditions are analyzed based on a 2-level mixed effect models for each outcome variable.

Conclusions

To our knowledge, this translational study is the first to provide data on genital arousal, sexual pleasure and PROMs in women with breast cancer during the use of vibrotactile stimulation. Findings can contribute to a better understanding of the interplay of psychological and physiological aspects the sexual function of breast cancer survivors to reveal targets to improve sexual function in this target group.

Conflicts of Interest

The authors are grateful to WOW Tech™ GmbH for their donation in support of the present research.

The funders do not participate in the study design, data collection, data analysis, or drafting of this abstract or future manuscripts.
(154) A CROSS-SECTIONAL STUDY OF FEMALE MASTURBATION PRACTICES AMONGST DIFFERENT POPULATIONS, AGE GROUPS AND THE INFLUENCING FACTORS
Authors: Markus van Niekerk
Published: July 2023

Objectives

To assess efficacy of sexual education in schools, whether female masturbation was included and whether it is sufficient in preparing adolescents for safe, consensual sex.To assess effects of religious, cultural, and parental factors on women’s views towards masturbation. To assess the frequency of the female orgasm when masturbating solo versus with a partner. To assess the nature of women’s emotions experienced when masturbating.

Methods

Cross-sectional anonymous online questionnaire with 24 questions both multiple choice and open ended. Inclusion criteria was female/identify as female, 18 years and older. Approval of the study by Riga Stradins Research Ethics Committee. Analyzation of data was conducted via the SPSS 27 system.

Results

With a sample size of 1068 participants, majority were European (46%) and North American (43%) ranging from age 18 and older. Sexual education was insufficient in 64.6% of cases with 43.3-55.8% of participants stating that sexual education was insufficient in preparing them for safe, consensual sex. With 84.4-85.2% stating that female masturbation was not discussed, 59% of participants indicated that female masturbation needs allocation during sexual education. Amongst 39.2% of participants, parents didn't discuss any sexual education with them with 29.8% of all participants being forbidden to engage in pre-marital sexual activity. Amongst those prohibited 38% still masturbated.

1.3% of participants underwent genital mutilation. Assessing frequency of masturbation majority (40.3%) reported to masturbate more than once weekly with the most popular mode of masturbation being sex toys (44%) followed by hands (42%).Comparing the frequency of orgasm while masturbating versus during sexual intercourse with a partner, 59% always report having an orgasm while masturbating solo; compared to 15% when with a partner. Emotions experienced by women during masturbation were mostly positive with the majority feeling relieved (68.7%).

Conclusions

Sexual education programs in schools need reassessment as they are insufficient in teaching about female masturbation and preparing students for safe and consensual sexual intercourse. Female masturbation should be considered a right to female sexual health, this needs to be ensured and included as a normal topic of discussion, no longer considered a taboo in society.

Conflicts of Interest

The abovementioned author, has no conflicts of interest to declare concerning the originality of the paper and there is no financial interest to report.
(248) DIRECT AND INDIRECT IMPACT OF INTERNAL WORKING MODELS OF SELF ON MALE SEXUAL FUNCTION
Authors: Dr. Daniele Mollaioli , Prof. Giacomo Ciocca , Dr. Erika Limoncin , Andrea Sansone , Dr. Elena Colonnello , Jannini Prof Emmanuele A
Published: July 2023

Objectives

Internal working models (IWM) represent the internal representation about the self, expressed by a sense of self-worth (+) or self-blaming (-), and significant others, expressed by the expectation of availability and support (+) or indifference (-), guiding the interpersonal strategies to regulate intimate affects and choosing romantic and sexual partners. Even if the relationship between IWM and close relationships has been deepen investigated, only few studies evaluate the impact of IWM on sexual function. Thus, we aim to investigate the interplay among IWM, dyadic cohesion and erectile and orgasmic function in males.

Methods

Through an online platform, a convenience sample of 1052 partnered males were recruited (age: 40.45±12.94). Enrolled subjects compiled a psychometric protocol composed of: the Dyadic Adjustment Scale (DAS); the Relationship Questionnaire (RQ); the Sexual Health Inventory for Men (SHIM); the Premature Ejaculation Diagnostic Tool (PEDT) and the Male Orgasmometer. Correlation, linear regression and mediation model analyses were performed.

Results

A significant positive correlation was found between the Model of Self (MS) and dyadic cohesion and sexological variables; on the other hand, no significant correlation was found between the Model of Other (MO) and sexological variable, unlike a positive correlation emerged between the MO and dyadic cohesion. Mediation Analysis evidenced the significant influence of MS towards erectile function (β=0.05), premature ejaculation (β=-0.03) and perceived orgasmic intensity (β=0.04), both directly and indirectly. Furthermore, dyadic cohesion significantly mediates the indirect pathways between the MS and sexological variables (β=0.03).

Conclusions

These results highlighted the important role of MS in the relational and sexual health and showed how internal representation of Self could, both directly and indirectly impact on the perception of dyadic and sexual experience and the onset of sexual dysfunctions, such as erectile dysfunction and premature ejaculation in male population.

Conflicts of Interest

The authors have no conflicts of interest to declare.
(73) STEREOTYPES ABOUT SINGLES: IS PUBLIC PERCEPTION OF ANOTHER PERSON’S LIFE- SATISFACTION AND SELF-SATISFACTION DEPENDENT ON THE OTHER PERSON’S RELATIONSHIP STATUS?
Authors: Priv-Doz. Nikola Komlenac , Carmen Mair , Prof. Margarethe Hochleitner
Published: July 2023

Objectives

The belief that everyone has a strong desire to be involved in a committed relationship can lead to stereotyping of singles (i.e., singlism). One stereotype is the characterization of single people as being unsatisfied with life. The current study explored whether people judge another person’s life-satisfaction and self-satisfaction differently, based on the information about the other person’s relationship status.

Methods

An online cross-sectional study with an experimental design was conducted among 642 persons (Mage = 39.2, SD = 13.1; 64.3% women, 35.7% men) in German-speaking countries. Each participant read one vignette, either describing a woman or a men, being either single (single), in an uncommitted relationship (uncommitted) or in a committed relationship (committed). Validated questionnaires for the assessment of life-satisfaction and self-satisfaction were modified so that participants could indicate how they perceived the character. Three informative hypotheses (H1: single=uncommitted=committed; H2: single<uncommitted<committed; H3: single<uncommitted=committed) were compared with Bayesian ANCOVA.

Results

Data did not support the hypotheses that single people, people in uncommitted relationships, and people in committed relationships were perceived to have similar life-satisfaction or self-satisfaction (H1). Support for H2 was found when people judged the male character’s life-satisfaction or self-satisfaction with social relationships. When participants judged the female character’s life satisfaction or self-satisfaction with social relationships H3 was supported strongest by the data. When participants judged the character’s self-satisfaction in regards to sexuality none of the hypotheses was supported.

Conclusions

Participants perceived lowest levels of self-satisfaction and life-satisfaction in single people. Thus, singlism seem to prevailing in the German-speaking sample, but differ for women and men. Whereas men who are in an uncommitted relationship were perceived less favorably than men who were in a committed relationship, such a difference in the perception of women in uncommitted and committed relationships was not found.

Conflicts of Interest

The study is funded by the Region of the Tyrol.
(77) ANAL POSITIONING IN GAY MEN. ARE THERE REALLY SO MANY BOTTOMS? THE TBORNOTTB STUDY: A SURVEY OF 8,755 MEN
Authors: Rafael J Herrero , Aurélie Bourmaud , Priv-Doz. Priscilla Boizeau , Dr. Michel Ohayon
Published: July 2023

Objectives

Sexual anal positioning amongst men who have sex with men (MSM) is central to the understanding of this population, with important repercussions on the sexological fulfillment of these individuals. The purpose of our study was to determine the real frequencies of the anal positions frequently referred to as “bottom,” “top,” “versatile,” and “side.” We also set out to verify if there were clear differences between “anal sexual identity (ASI),” “anal sexual behavior (ASB),” and “anal sexual preference (ASP).”

Methods

An on-line anonymous questionnaire was made available in the French language to all cisgender MSM of at least 18 years of age between June 25 and October 26 2020, on the subject of anal positioning. The questionnaire presented 104 questions, with a total of 190 items being evaluated. Descriptive and analytical analyses were performed according to a statistical analysis plan drafted prior to implementation of study. Parametric or non-parametric tests were performed according to the distribution of variables. Statistical significance was set at 0.05.

Results

9.734 individuals clicked on our questionnaire. After informed consent, 9,686 declared they desired to participate. 8,755 respondents met all inclusion criteria for statistical analysis. For ASI, 40.8% of respondents declared to be “bottoms,” 30.8% to be “versatile, and 24,0% to be “tops.”

Conclusions

The TBornotTB study is the largest study to date on anal sexual positioning amongst MSM. Anal intercourse is clearly important to MSM. Receptive ASI was by far the most frequent ASI, the least frequent ASB was versatile, but Versatile ASP was what was desired by the vast majority. Our study underscores the importance of distinguishing three categories: identity, behavior, and desire. Significantly, it puts the spotlight on an area of sexuality that therapists may need to consider while working with MSM: the reduction of the splitting between these three sexological entities.

Conflicts of Interest

No conflicts of interest to be declared.
(61) UNLEASHED DESIRE: IS THERE ALTERED RESTING STATE FUNCTIONAL CONNECTIVITY IN MEN WITH COMPULSIVE SEXUAL BEHAVIOR DISORDER?
Authors: Dr. Jannis Engel , Dr. Christopher Sinke , Maria Veit , Dr. Jonas Kneer , Prof. Uwe Hartmann , Prof. Tillmann H Krüger
Published: July 2023

Objectives

Problems arising from compulsive sexual behavior disorder (CSBD) are often seen in clinical settings. In the sex@brain study we aimed to extend the knowledge about the clinical characteristics and the underlying neurobiology of individuals with CSBD.

Methods

We used a seed-based resting state fMRI approach investigating state functional connectivity in CSBD. A group of men with CSBD (n = 39) was compared to a group of healthy controls (n = 33). Groups were matched for age and educational level. The focus of this investigation lies on frontal and limbic regions highly relevant for emotional processing and behavioral control.

Results

Initial results showed increased connectivity between the left amygdala and left Precuneus/superior parietal cortex as well decreased connectivity between the right middle OFC and gyrus rectus in men with CSBD compared to healthy controls. Moreover, attenuated connectivity between putamen and anterior cingulate cortex was found in men with CSBD when compared to healthy controls.

Conclusions

The results highlight the importance of a strong functional connectivity between limbic regions and areas involved in attention. In addition, a diminished connectivity between parts of the reward system and areas involved in sexual inhibition was observed. These results, however, should to be interpreted with caution, as different studies in the field show very divergent results. Further research is needed for the understanding of the interplay between emotional and behavioral control and may contribute to a better understanding of sexual compulsive behavior and may lead to more differentiated and effective diagnostics and treatment.

Conflicts of Interest

none
(194) EXTERIORIZATION OF ADULT-ACQUIRED BURIED PENIS WITH SCROTAL FLAP AND SKIN MESH-GRAFT, GLANS MUCOSECTOMY, AND VENTRAL MEATOTOMY
Authors: Omid Sedigh , Andrea Gobbo , Nicola Faraone , Ernesto Giargia , Devis Collura , Marisa Kurti , Paolo Caccia , Andrea Formiconi , Alessandro Giacobbe
Published: July 2023

Objectives

We present the treatment of a patient with partial Adult-acquired buried penis (AABP) and extreme tissue retraction, complaining of genital skin tension and LUTS.

Methods

Penile exteriorization was performed after circumcision. Glans mucosectomy was carried out because of suspicious glans mucosa. Ventral meatotomy was performed because of the stenotic meatus. For penile covering, we used scrotal skin for the shaft and skin mesh-graft for the glans. The scrotum was positioned around the penile shaft with a rotation flap. For the skin mesh graft we chose as donator the anterior thigh. Harvesting with a scalpel was preferred, so closure by primary intention was possible. We did not use the dermatome considering the low general self-care of the patient and the likely inadequate management of the wound with subsequent risk of infection or dysfunctional scarring. For the same reason we decided to use the smallest graft possible and to mesh it, to allow a better attachment and prevent hematoma or seroma under the graft. After the surgery the medication was sutured to the penis and maintained for one week, afterwards medications were performed 2 times per week for 21 days.

Results

The operation lasted 165 minutes. No complications occurred intraoperatively. Stretched penis measured 7cm before surgery and 14cm after. At the first medication there was scrotum necrosis with wound dehiscence, it was removed entirely and exudative material covering the graft was cleaned. At successive medications, the genitals showed good healing process and minimum scarring of the mesh-graft. The patient referred good urinary function and aesthetic satisfaction without genital discomfort.

Conclusions

For AABP at risk of non-optimal management of the wound after the operation, tissues with good attachment proprieties like scrotum and mesh-grafts can be safely used with good functional results.

Conflicts of Interest

none
(34) MULTIPLE SLIT INCISIONS WITH TACHOSIL® GRAFTING FOR TREATMENT OF PEYRONIE’S DISEASE AND ED
Authors: Ahmed Ragheb , Prof. Daniar Osmonov
Published: July 2023

Objectives

We demonstrate step-by-step the treatment of a case of severe ED with an over 60 degree dorsal curvature mainly on the left side and an hour glass indentation on the right side of the penile shaft. We highlight the advantages of multiple plaque incisions and Tachosil® grafting combined with inflatable penile prosthesis (IPP) implantation for these specific cases.

Methods

After IPP implantation via the penoscrotal approach, the neurovascular bundle was mobilized. For the left sided dorsal curvature we underwent multiple deep transverse slits starting from and around the point of maximum curvature using a low energy cutting current (20 to 30 Watts). Our transverse incisions were complimented with the modeling technique. For the right sided waist formation we underwent longitudinal slits. Subsequently, the area of incisions was covered by a Tachosil® graft.

Results

The multiple horizontal incisions led to a vertical release thus straightening of the curved penile shaft. Longitudinal slits led to a horizontal release, therefore expanding and obliterating the waist formation.

Conclusions

The multiple slit technique together with Tachosil® grafting may have added advantages compared to the conventional plaque incision/excision utilizing the same graft. The smaller defects created by the multiple tunical incisions may avoid potential cylinder protrusion, facilitate better sealing of the collagen fleece, lower the incidence of hematoma and/or infections and allow complimentary modeling of the penis. Moreover, complex deformities may also be treated simultaneously with success.

Conflicts of Interest

The authors have no conflict of interest.
(31) THE IMPACT OF SEXUAL VIOLENCE ON QUALITY OF LIFE AND MENTAL WELL-BEING OF TRANSGENDER AND GENDER DIVERSE INDIVIDUALS
Authors: Aisa Burgwal , Prof. Joz Motmans
Published: July 2023

Objectives

Transgender (trans) and gender diverse (GD) individuals have remained largely invisible in health research. Previous research shows worse outcomes on health indicators for trans people when compared to cisgender controls. Research on the impact of sexual violence focuses on mainly cisgender female victims. This study assessed the impact of sexual violence on quality of life (QoL) and mental well-being among trans and GD individuals.

Methods

An online, anonymous survey was conducted between Oct/21 and Jan/22 in Belgium. QoL and well-being were analyzed for differences between trans and GD victims of sexual violence versus non-victims. A backward regression analysis was applied, attempting to obtain a sexual violence model to explain significant differences in health-related outcomes. The effects of multiple control variables (gender identity, sexual orientation, age, income, ...) were taken into account within the modeling approach.

Results

The sample consisted of 310 respondents aged 15 years and older, with 107 (34.5%) transgender respondents and 203 (65.5%) GD respondents. 71.6% reported experiences with sexual violence over the past two years (n = 166). The backward regression analyses showed that sexual violence did not significantly impact QoL (p = .536), but it did have a significant impact on mental well-being (GHQ-12, p = .001). Other variables proved to be of importance in predicting QoL, such as age, socio-economic status, employment, relationship status, and living according to one’s own gender identity. Sexual violence predicted a significantly higher score on the GHQ-12 and thus predicted more psychological problems. Also age predicted mental well-being.

Conclusions

In understanding health disparities among trans and GD people, it is necessary to take into account the additive effect of multiple socio-economic positions. The high proportion of sexual violence, as well as the lower average QoL and mental well-being outcomes among trans and GD people compared to general population statistics, highlights the need for policy makers to create inclusive environments.

Conflicts of Interest

We hereby declare that there is no conflict of interest by submitting this abstract. The abstract and presentation are completely free from commercial influence or bias.
(91) INTRACAVERNOSAL AVIPTADIL WITH PHENTOLAMINE MESYLATE AS AN ALTERNATIVE TREATMENT FORREFRACTORY ERECTILE DYSFUNCTION
Authors: Fiona Holden , Clare Akers , Prof. David Ralph , Gin Lee Wai
Published: July 2023

Objectives

Vasoactive intestinal peptide (aviptadil) with phentolamine mesylate (Invicorp) was first used for erectile dysfunction (ED) in 1992. The advent of oral phosphodiesterase-5 inhibitors and the availability of intracavernosal alprostadil injections (ICAI) compounded by regulatory issues for Invicorp have limited the use and availability of this medication. Invicorp causes less pain on injection and may have a role following failure of ICAI but contemporary experience is limited.

Methods

Single centre retrospective review of all patients referred for trial of Invicorp after failing ICAI due to pain or poor efficacy following titration to at least 40mcg. The first injection was performed in clinic with either a half (12.5mg aviptadil/1mg phentolamine) or full (25mg aviptadil/2mg phentolamine) dose followed by a telephone call in 6 weeks. Efficacy was assessed by patient history after 3 months.

Results

163 men with a median age of 60 years (IQR 53-67) were referred after failing median ICAI dose of 20mcg (IQR 10-40). Aetiology of ED was post radical prostatectomy in 49% and diabetes in 31.9%. All men had failed oral phosphodiesterase-5 inhibitors and 75% found vacuum erection devices inadequate. 61% found ICAI too painful and were unable to titrate their dose higher while others reported poor response. Almost two-thirds (63.2%) found Invicorp effective and allowed sexual activity to resume (Table 1). Some (15%, n=24) stopped Invicorp despite good efficacy because they wanted to stop using injectables or experienced improvement in their erectile function over time (post radical prostatectomy). Fifty-three (32.5%) men developed adverse reactions following injection, primarily facial flushing (92%). No episodes of iatrogenic priapism were reported.

Conclusions

Invicorp offers an effective and acceptable third line option for men who have failed most non-surgical treatment for ED in the largest study to date. Many (63%) were given an alternative to penile prosthesis insertion by being offered Invicorp. Invicorp was well-tolerated and only 4 patients in this cohort (2.5%) stopped due adverse effects.

Conflicts of Interest

Nil