bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of cell–cell and cell–matrix junctional complexes in sebaceous gland homeostasis and differentiation
Authors: Yaba Aylin , Thalheim Torsten , Schneider Marlon R.
Published: September 2024

Sebaceous glands (SG) are essential for maintaining skin integrity, as their lipid-rich secretion (sebum) lubricates and protects the epidermis and hairs. In addition, these glands have an emerging role in immunomodulation and may affect whole-body energy metabolism, besides being an appealing model for research in topics as lipogenesis, stem cell biology and tumorigenesis. In spite of the increasing interest in studying SGs pathophysiology, sebocyte cell–cell and cell–matrix adhesion processes have been only superficially examined, and never in a systematic way. This is regrettable considering the key role of cellular adhesion in general, the specific expression pattern of indivdual junctional complexes, and the reports of structural changes in SGs after altered expression of adhesion-relevant proteins. Here, we review the available information on structural and functional aspects of cell–cell and cell–matrix junctions in sebocytes, and how these processes change under pathological conditions. This information will contribute for better understanding sebocyte differentiation and sebum secretion, and may provide hints for novel therapeutic strategies for skin diseases.
Fetal and obstetrics manifestations of mitochondrial diseases
Authors: Adelizzi Alessia , Giri Anastasia , Di Donfrancesco Alessia , Boito Simona , Prigione Alessandro , Bottani Emanuela , Bollati Valentina , Tiranti Valeria , Persico Nicola , Brunetti Dario
Published: September 2024

During embryonic and neonatal development, mitochondria have essential effects on metabolic and energetic regulation, shaping cell fate decisions and leading to significant short- and long-term effects on embryonic and offspring health. Therefore, perturbation on mitochondrial function can have a pathological effect on pregnancy. Several shreds of evidence collected in preclinical models revealed that severe mitochondrial dysfunction is incompatible with life or leads to critical developmental defects, highlighting the importance of correct mitochondrial function during embryo-fetal development. The mechanism impairing the correct development is unknown and may include a dysfunctional metabolic switch in differentiating cells due to decreased ATP production or altered apoptotic signalling. Given the central role of mitochondria in embryonic and fetal development, the mitochondrial dysfunction typical of Mitochondrial Diseases (MDs) should, in principle, be detectable during pregnancy. However, little is known about the clinical manifestations of MDs in embryonic and fetal development. In this manuscript, we review preclinical and clinical evidence suggesting that MDs may affect fetal development and highlight the fetal and maternal outcomes that may provide a wake-up call for targeted genetic diagnosis.
Evidence for seasonal migration by a cryptic top predator of the deep sea
Authors: Oestreich William K. , Benoit-Bird Kelly J. , Abrahms Briana , Margolina Tetyana , Joseph John E. , Zhang Yanwu , Rueda Carlos A. , Ryan John P.
Published: September 2024

Background

In ecosystems influenced by strong seasonal variation in insolation, the fitness of diverse taxa depends on seasonal movements to track resources along latitudinal or elevational gradients. Deep pelagic ecosystems, where sunlight is extremely limited, represent Earth’s largest habitable space and yet ecosystem phenology and effective animal movement strategies in these systems are little understood. Sperm whales (Physeter macrocephalus) provide a valuable acoustic window into this world: the echolocation clicks they produce while foraging in the deep sea are the loudest known biological sounds on Earth and convey detailed information about their behavior.

Methods

We analyze seven years of continuous passive acoustic observations from the Central California Current System, using automated methods to identify both presence and demographic information from sperm whale echolocation clicks. By integrating empirical results with individual-level movement simulations, we test hypotheses about the movement strategies underlying sperm whales’ long-distance movements in the Northeast Pacific.

Results

We detect foraging sperm whales of all demographic groups year-round in the Central California Current System, but also identify significant seasonality in frequency of presence. Among several previously hypothesized movement strategies for this population, empirical acoustic observations most closely match simulated results from a population undertaking a “seasonal resource-tracking migration”, in which individuals move to track moderate seasonal-latitudinal variation in resource availability.

Discussion

Our findings provide evidence for seasonal movements in this cryptic top predator of the deep sea. We posit that these seasonal movements are likely driven by tracking of deep-sea resources, based on several lines of evidence: (1) seasonal-latitudinal patterns in foraging sperm whale detection across the Northeast Pacific; (2) lack of demographic variation in seasonality of presence; and (3) the match between simulations of seasonal resource-tracking migration and empirical results. We show that sperm whales likely track oceanographic seasonality in a manner similar to many surface ocean predators, but with dampened seasonal-latitudinal movement patterns. These findings shed light on the drivers of sperm whales’ long-distance movements and the shrouded phenology of the deep-sea ecosystems in which they forage.
Recovery at your fingertips: pilot study of an mHealth intervention for work-related stress among nursing students
Authors: Kowalski Leo , Finnes Anna , Koch Sabine , Stenling Andreas , Bujacz Aleksandra
Published: September 2024

Background

Work-related stress is detrimental to individual health and incurs substantial social costs. Interventions to tackle this problem are urgently needed, with mHealth solutions being a promising way of delivering accessible and standardized interventions on a wide scale. This study pilot tests a low-intensive mHealth intervention designed to mitigate the negative consequences of stress through promoting recovery strategies.

Methods

Nursing school students (N = 16) used the intervention for a month. Data were collected immediately before, immediately after, and one month after the end of the intervention. Additionally, intensive longitudinal data were collected daily during the time of the intervention. Primary outcome measures include recruitment and retention rates, engagement with and acceptability of the intervention, as well as evaluating the quality of measurement instruments.

Results

Recruitment and retention rates provide a benchmark that we need to invite 10–12 times the intended target sample size. Engagement and acceptability metrics are promising overall, showing key areas that need to be adapted to improve the intervention. Measurement quality is acceptable with instruments mostly functioning as intended.

Conclusion

Results show that the intervention and study protocol are feasible for conducting a randomized controlled trial given a few adjustments. The randomization algorithm needs to match the sample size in order to allocate evenly distributed experimental groups. Acceptability of the intervention may be improved through adapting the recommended recovery strategies. Some additional outcome measures are suggested to provide a more comprehensive picture of intervention effects.

Trial registration

NCT06228495. Registered retrospectively 01/10/2024.
Disrupting the Master Narrative in Academic Biology as LGBTQ+ Ph.D. Students: Learning, Teaching, and Conducting Research
Authors: Maas Samantha A. , Wiesenthal Nicholas J. , Brownell Sara E. , Cooper Katelyn M.
Published: September 2024

This interview study of 22 LGBTQ+ biology Ph.D. students across 13 institutions examines how they navigate heterocisnormativity and assumed neutrality master narratives. Students recognize the presence of these narratives in biology. They disrupt these narratives by teaching in inclusive ways and sharing their identities with others.
Towards a unified theory of the aetiology of schizophrenia
Authors: Jiang Yuchao , Chang Xiao , Feng Jianfeng
Published: September 2024

We emphasise the existence of two distinct neurophysiological subtypes in schizophrenia, characterised by different sites of initial grey matter loss. We review evidence for potential neuromolecular mechanisms underlying these subtypes, proposing a biologically based disease classification approach to unify macro- and micro-scale neural abnormalities of schizophrenia.
The Promise of Beauty
Authors: Nguyen Mimi Thi
Published: September 2024

In The Promise of Beauty, Mimi Thi Nguyen explores the relationship between the concept of beauty and narratives of crisis and catastrophe. Nguyen conceptualizes beauty, which, she observes, we turn to in emergencies and times of destruction, as a tool to identify and bridge the discrepancy between the world as it is and what it ought to be. Drawing widely from aesthetic and critical theories, Nguyen outlines how beauty—or its lack—points to the conditions that must exist for it to flourish. She notes that an absence of beauty becomes both a political observation and a call to action to transform the conditions of the situation so as to replicate, preserve, or repair beauty. The promise of beauty can then engender a critique of social arrangements and political structures that would set the foundations for its possibility and presence. In this way, Nguyen highlights the role of beauty in inspiring action toward a more just world.
Microsurgical Anatomy of the Common Tendinous Ring and Its Surgical Implications
Authors: Huang Ying , Wang Xu , Tian Zhi-Feng , Cai Li , Wang Xu-Ming , Tang Dan , Ren Jian , Liu Xiao-Hai , Chen Ge , Hu Peng , Li Ming-Chu
Published: September 2024

BACKGROUND AND OBJECTIVES:

The common tendinous ring (CTR), also known as the common annular tendon or annulus of Zinn, is a critical anatomic structure located at the convergence of the orbital apex, superior orbital fissure (SOF), optic canal, and the anterior aspect of the lateral sellar compartment. It plays a vital role in both neurosurgical and neuro-ophthalmological interventions. The aim of this study was to delineate the complex 3-dimensional (3D) topography of the CTR and explore its implications for surgical procedures.

METHODS:

Ten formalin-fixed skull base specimens from adult Chinese cadavers were meticulously dissected to investigate the morphology of the CTR, focusing particularly on its relationship with the 4 extraocular rectus tendons, the optic strut, the SOF, and the optic canal. Additional skull base specimens were subjected to 3D surface scanning, computed tomography, and histopathological examinations to deepen our understanding of the CTR's structural complexities.

RESULTS:

The CTR establishes a spatial, 3D tendinous assembly, encompassing 4 rectus tendons, 2 tendinous connections, and a singular common tendinous root. These components interlink to form a distinctive dual-ring configuration, featuring the optic foramen and the oculomotor foramen. The posterior part of the superior rectus tendon demarcates the common boundary between these 2 foramina. The oculomotor foramen itself serves as the central sector of the SOF. Precise incisions of the medial and lateral tendinous connections and fusions are essential for safely opening the CTR.

CONCLUSION:

The structural composition, interconnections, and dual-ring configuration of the CTR are crucial for precise and safe surgery of orbital apex and adjacent regions.
Effects of Muay Thai Practice on Self-Esteem, Body Perception, and Quality of Life in Adolescents with Overweight/Obesity
Authors: Saraiva Bruna Thamyres Ciccotti , Henn Rafael Rodrigues , Tebar William Rodrigues , dos Santos Amanda Barbosa , Antunes Ewerton Pegorelli , Ferrari Gerson , Christofaro Diego Giulliano Destro
Published: September 2024

Introduction

The aim of this study was to analyze the effects of 16 wk of Muay Thai practice on body perception, self-esteem, and quality of life in adolescents with overweight/obesity.

Methods

The sample consisted of adolescents with overweight/obesity, aged 10–17 yr. Overweight/obesity was confirmed using body mass index (BMI) and body fat (BF). Body mass and height were measured, from which BMI was calculated. BF was assessed using dual-energy x-ray absorptiometry. Body perception was measured using the Brazilian Silhouette Scale for Children, self-esteem was measured using the Rosenberg Self-Esteem Scale, and quality of life was measured using the 36-Item Short Form Health Survey. The Muay Thai intervention lasted 16 wk, with the initial 4 wk intended for adaptation and familiarization. Sessions were held three times per week on nonconsecutive days for 1.5 h. Protective equipment and devices, such as gloves, Thai pads, gauntlets, and head and rib protectors, were used. Training intensity was maintained between moderate and high according to the rate of perceived exertion scale. The control group did not perform any type of systematic training.

Results

There was a statistically significant group effect for self-esteem only (P < 0.01; effect size (η
2) = 0.13). When analyzing η
2, there was a group × time interaction in the pain domain of quality of life (P = 0.07; η
2
p = 0.11) considered medium to large. Furthermore, increases were observed in the prevalence of healthy self-esteem (before, 65.0%; after, 73.1%) and satisfaction with body image (before, 0%; after, 3.8%) in the Muay Thai group.

Conclusion

Muay Thai led to increased prevalences of individuals satisfied with their body image and with healthy self-esteem, as well as an increase in the pain domain score of quality of life in adolescents with overweight/obesity.
Minority citizen-soldiers, mobilizations & discrimination in the Ottoman Empire and the Kingdom of Greece during the early 20th century
Authors: Μηνασίδης Χαράλαμπος
Published: September 2024

Αυτή η διατριβή είναι μια συγκριτική, διεθνική και σχεσιακή ανάλυση των μειονοτικών πολιτών-στρατιωτών στον οθωμανικό και τον ελληνικό στρατό που υπηρέτησαν κατά τον Μακρύ Πόλεμο (1911–1922) και επίσης συμμετείχαν σε μεταξύ τους πολέμους. Εξετάζει τη σχέση που αναπτύχθηκε μεταξύ των δύο κρατών και των στρατεύσιμων μειονοτήτων τους και τον αντίκτυπο των συνεχών πολέμων σε αυτή τη σχέση. Αναλύει τις προσπάθειες των κρατών να συνδέσουν την υπηρεσία με την ιθαγένεια και τις πολιτικές τους για την ένταξη και τον αποκλεισμό των στρατεύσιμων μειονοτήτων, καθώς και τις αντιδράσεις και τη στάση των τελευταίων απέναντι στη στρατιωτική και πολεμική τους θητεία. Είναι επίσης μια μελέτη των σχέσεων πλειονοτικών-μειονοτικών πολιτών-στρατιωτών εν μέσω πολέμου. Οι πλειονοτικοί και οι μειονοτικοί πολίτες-στρατιώτες είχαν διακριτές (αλλά μερικές φορές παρόμοιες) τροχιές στις πρώτες φάσεις του Μακρύου Πολέμου, αλλά μέχρι το τέλος του πολέμου δεν μπορούσαν να συσχετίσουν μεταξύ τους τις αποκλίνουσες εμπειρίες τους. Αυτή η διατριβή διερευνά επίσης μια ομάδα που χρησίμευσε ως κοινή δεξαμενή κινητοποίησης και από τα δύο κράτη, τους Οθωμανούς Έλληνες Ορθόδοξους πολίτες-στρατιώτες, και αναλύει τη στάση τους απέναντι στον πόλεμο και την πιθανότητα να γίνουν Έλληνες πολίτες. Αντλώντας από πηγές βάσης όπως ημερολόγια, απομνημονεύματα, επιστολές και προφορικές συνεντεύξεις, αυτή η διατριβή παράγει μια ιστορία των μειονοτικών πολιτών-στρατιωτών από τα κάτω και εμβαθύνει στις εμπειρίες τους, τα συναισθήματά τους και την πολυπλοκότητα της δράσης τους. Υποστηρίζει ότι οι άξονες της ένταξης και του αποκλεισμού τους καθορίστηκαν όχι μόνο από τον τρόπο που οι πολιτικές ηγεσίες και των δύο κρατών αντιμετώπισαν τη στράτευση των μειονοτήτων αλλά και από τις πολεμικές ανάγκες. Ο πόλεμος αποκάλυψε τους περιορισμούς των οθωμανικών και ελληνικών περιεκτικών εθνικισμών και οι μειονοτικοί πολίτες-στρατιώτες, οι ένοπλοι κλάδοι των κοινοτήτων τους, ήταν οι πρώτοι που έγιναν μάρτυρες και έπεσαν θύματα των συνεχιζόμενων αλλαγών. Εν μέσω του πολέμου, το ανθρώπινο τοπίο της ολοκληρωτικής κινητοποίησης έγινε σταδιακά λιγότερο πλουραλιστικό και πιο διαχωρισμένο, καθώς η ομογενοποίηση του στρατού έγινε ζήτημα κρατικής και εθνικής ασφάλειας. Ο πόλεμος είχε γίνει ουσιαστικά ένα εργαστήριο οικοδόμησης εθνών, επιβάλλοντας μια μεταπολεμική πλειονοκεντρική οικοδόμηση ειρήνης και μνήμης, όπου οι περισσότεροι βετεράνοι της μειονότητας δεν ανήκαν πια. Η μονομερής κατάργηση του πολεμικού συμβολαίου σήμαινε ότι είχαν κινητοποιηθεί, υπηρετήσει και μερικές φορές πολεμήσει, για το τίποτα.
L’agressivité hétéro-adressée pendant l’adolescence comme tentative de séparation
Authors: Καρδαρά Ελένη
Published: September 2024

Κατά την εφηβεία, η ετερο-επιθετική συμπεριφορά έχει μελετηθεί κυρίως στο πλαίσιο της παραβατικότηταw ή κατά τα ψυχωτικά επεισόδια. Λίγες μελέτες έχουν διεξαχθεί σε εφήβους των οποίων η επιθετική συμπεριφορά τους έχει οδηγήσει είτε στη δικαιοσύνη για σοβαρή βλάβη στην ακεραιότητα των άλλων είτε σε ψυχιατρικό νοσοκομείο για μείζον ψυχωτικό επεισόδιο. Η έρευνά μας στοχεύει να διερευνήσει την έννοια της ετερο-επιθετικής συμπεριφοράς και τη σύνδεσή της με την έλευση της εφηβείας, την αντικειμενότροπο σχέση και τον αποχωρισμό από τις φιγούρες φροντίδας πέρα ​​από μία συγκεκριμένη διάγνωση. Ξεκινώντας από κλινικές παρατηρήσεις που αποκαλύπτουν το συμπεριφορικό σύμπτωμα της ετερο-επιθετικής συμπεριφοράς και από οποιαδήποτε διαγνωστική διερεύνηση, αναρωτηθήκαμε τι διαδραματίζεται ενδοψυχικά σε αυτούς τουςεφήβους. Αυτή η έρευνα αφορά στη σχέση μεταξύ της εφηβείας και της ετερο-επιθετικής συμπεριφοράς, που συνδέονται στενά με το ζήτημα της σχέσης αντικειμένου και ειδικότερα με το ερώτημα του αποχωρισμού. Προκειμένου να διερευνηθούν οι ενδοψυχικές διεργασίες μέσα στο συμπεριφορικό σύμπτωμα αυτών των ετεροεπιθετικών συμπεριφορών, χορηγήσαμε προβολικές δοκιμασίες (Rorschach και TAT), σύμφωνα με την μεθοδολογία της Σχολής του Παρισιού, σε 14 εφήβους, μεταξύ 15 και 18 ετών, που παραακολουθούνταν από τρεις εξωνοσοκομειακές υπηρεσίες. Όλοι οι έφηβοι είχαν ιστορικό πολλαπλών επιθετικών συμπεριφορών προς τους οικείους τους, χωρίς όμως να βλάψουν σοβαρά τη ζωή τους. Τα αποτελέσματα δείχνουν τη δυσκολία πρόσβασης σε εσωτερικά αντικείμενα και την έλλειψη στήριξης, την απουσία ή την ανεπάρκεια δόμησης οιδιπόδειων σημείων αναφοράς, την ενόρμηση της κυριαρχίας στη θέση της αντικειμενότροπου σχέσης και την αδυναμία να μείνει κανείς μόνος.
Platelet-Rich Plasma (PRP) in Hair Restoration Treatments: A Comprehensive Review of Existing Literature
Authors: Cyran Piotr , Jaroszyńska Anna , Jaroszyński Filip , Kowal Joanna , Paleczny Jan , Parobczak Robert , Połujański Paweł , Winciorek Joanna , Wiśniewska Adrianna
Published: September 2024

Hair loss is a common concern affecting individuals worldwide. With various therapies available to address this issue, it prompts the search for effective treatments and prevention methods. Platelet-Rich Plasma (PRP) therapy has emerged as a promising option for hair restoration, leveraging the regenerative properties of platelets to stimulate hair growth.
This comprehensive review aims to synthesize the existing literature on the use of PRP in hair restoration treatments. A systematic search of major databases was conducted to identify relevant studies evaluating the efficacy and safety of PRP therapy for hair loss of the scalp. Eligible studies were selected based on predetermined inclusion criteria, and data extraction was performed to capture key findings, including patient demographics, PRP preparation methods, treatment protocols, and outcomes measured.
The review encompasses both clinical trials and observational studies, providing insights into the effectiveness of PRP therapy in promoting hair regrowth, improving hair density and therefore enhancing patient satisfaction. Additionally, safety considerations, adverse events, and limitations of current evidence are discussed.
Overall, this review highlights the growing body of evidence supporting the use of PRP in hair restoration treatments while identifying areas for further research and clinical refinement.
Koń jako kolonizator? Przypadek Południowej Afryki, do drugiej połowy XIX wieku
Authors: Leśniewski Michał
Published: September 2024

Południowa Afryka od połowy XVII w. przeżywała okres daleko idących przemian, związanych z europejską aktywnością handlową i kolonialną. W kontakcie z Europejczykami dochodziło do zmian w lokalnych społeczeństwach, a jednocześnie do połowy XIX w. był to jedyny obszar w Afryce, na terenie którego możemy mówić o europejskim osadnictwie i jego ekspansji. W procesach tych niebagatelną rolę odegrały konie.
Nordic walking – the healthiest sport ever? – A review
Authors: Szpulak Angelika , Makłowicz Aleksandra , Kopczyńska Ewelina , Frańczuk Agata , Grzelka Michalina , Głoskowska Julia , Kuleta Katarzyna , Słychan Katarzyna , Kuśmierczyk Katarzyna , Karkos Patrycja
Published: September 2024

Nordic Walking (NW) is a widely practiced sport that was originally intended as a way for cross-country skiers to get a year-round workout. However, it quickly proved to be easy, enjoyable and undemanding, which led populations around the world to train NW. Today, the sport is used as rehabilitation in most medical specialties, as it is considered to be safe, not creating barriers, inexpensive and has no side effects. This article presents a literature review on the effects of NW on patients' mental and physical health.
The Role of Physical Activity in the Rehabilitation of Children with Fetal Alcohol Syndrome: Why It Should Be Considered a Vital Part of Treatment
Authors: Dyląg Liliana , Graca Magdalena , Szopińska Kinga , Łowicka Weronika , Wawszkowicz Konrad , Oluszczak Karolina , Szeliga Anna , Korta Karolina , Szostak Agata , Śmigielska-Mikołajczyk Maria Janina
Published: September 2024

This literature review examines the pivotal role of physical activity in the treatment and rehabilitation of children with Fetal Alcohol Syndrome (FAS). By analysing a range of research studies, this review identifies the beneficial impact of structured physical activity programmes on motor skills, cognitive functions, and behavioural outcomes in children with FAS. Furthermore, it proposes educational recommendations for integrating physical activity into therapeutic interventions.
Análisis de la competencia digital en profesores de educación primaria en relación con los factores de género, edad y experiencia
Authors: González-Medina Isaac , Pérez-Navío Eufrasio , Gavín Chocano Óscar
Published: September 2024

La competencia digital docente se ha vuelto crucial para transformar a los profesores en diseñadores eficaces de procesos instruccionales adaptados a las necesidades de su alumnado. Sin embargo, esta competencia no es uniforme entre el profesorado, con las variables género, edad y años de experiencia como aspectos a considerar. Al respecto, el objetivo de este estudio fue examinar el nivel de competencia digital de profesores de enseñanza básica, según las variables género, edad y sus años de experiencia. Asimismo, se buscó analizar el nivel competencial percibido de los docentes y su contraste una vez reflexionado sobre las diferentes dimensiones que componen la competencia digital. Para ello, se administró el cuestionario DigCompEdu Check-in a 750 profesores de enseñanza básica. Los resultados apuntaron a que los hombres tienden a puntuar más alto en las dimensiones que componen la competencia digital docente. De acuerdo a la edad, los profesores destacaban en diferentes dimensiones en cada uno de los rangos establecidos y la percepción sobre su competencia digital fue superior en el pretest. Las implicaciones prácticas derivadas del estudio apuntan a la importancia de profesionalizar a los docentes a través del fomento de su competencia digital.
Inteligencia artificial: revolución educativa innovadora en la Educación Superior
Authors: Villegas-José Virginia , Delgado-García Manuel
Published: September 2024

Es una realidad que, en la universidad, la innovación educativa y las inteligencias artificiales están estrechamente relacionadas. Son múltiples los beneficios resultantes de integrar la IA en la práctica docente, así como la mejora el proceso de enseñanza-aprendizaje. Esta investigación se plantea desde una metodología cuantitativa, a través de un cuestionario formado de tres escalas diferentes (previamente validadas) sobre la práctica docente, la innovación educativa y la consideración hacia las inteligencias artificiales por parte del profesorado universitario. Se obtuvo una muestra de 159 docentes de la Universidad de Huelva; con el objetivo de explorar sus opiniones sobre la IA, sus actitudes hacia la innovación educativa y su relación con las prácticas docentes. Los resultados revelaron que factores como el género son significativos en la actitud hacia la innovación. Además, se observó que la edad del profesorado influye en la actitud hacia la IA, de forma que el profesorado más joven es el que más utiliza las IA en las aulas y también tiende a ser el que más innova. En general, el profesorado tiene una opinión más positiva sobre el uso de la IA en investigación que en docencia, donde aún se localizan ciertas reticencias.
Validación de una Herramienta de Evaluación Basada en el Modelo Rasch para Medir la Resolución Creativa de Problemas en Estudiantes Mediante el Uso de TIC
Authors: Farida Farida , Aspat Alamsyah Yopes , Sri Anggoro Bambang , Andari Tri , Lusiana Restu
Published: September 2024

A pesar del creciente reconocimiento de la importancia de la resolución creativa de problemas (CPS) a través del uso de las TIC en la educación con un currículo independiente, existe una falta de validación psicométrica integral para los instrumentos de evaluación de CPS. Este estudio tuvo como objetivo desarrollar y evaluar un instrumento de evaluación para medir la CPS a través del uso de las TIC en estudiantes, utilizando el modelo Rasch. Participaron un total de 137 estudiantes de educación superior como encuestados. Para este propósito, se crearon 20 ítems que cubrían diferentes aspectos de la CPS. El análisis de datos se realizó utilizando el software Winstep y SPSS. Se empleó el modelo Rasch para confirmar la validez y fiabilidad del instrumento de medición recién desarrollado. Los hallazgos del análisis del modelo Rasch indicaron un buen ajuste entre los ítems de evaluación y los estudiantes individuales. Los ítems demostraron un ajuste adecuado con el modelo Rasch, lo que permitió diferenciar los niveles de dificultad entre diferentes ítems y mostró un nivel satisfactorio de fiabilidad. El análisis del mapa de Wright reveló patrones de interacción entre los ítems y los individuos, discriminando efectivamente entre los diversos niveles de habilidades de los estudiantes. En particular, un ítem mostró DIF basado en el género, lo que favorece a los estudiantes varones en términos de sus habilidades de respuesta. Además, el estudio identificó que las estudiantes en el cuarto semestre exhibieron habilidades de respuesta promedio más altas en comparación con las estudiantes en el sexto y octavo semestre. Además, se observaron diferencias significativas en las habilidades de respuesta entre estudiantes varones y mujeres, así como entre estudiantes que residen en áreas urbanas y rurales. Estos hallazgos son cruciales para los educadores, enfatizando la necesidad de implementar estrategias de diferenciación efectivas
Comparison Between Mean-Variance and Monotone Mean-Variance Preferences Under Jump Diffusion and Stochastic Factor Model
Authors: Li Yuchen , Liang Zongxia , Pang Shunzhi
Published: September 2024

This paper compares the optimal investment problems based on monotone mean-variance (MMV) and mean-variance (MV) preferences in a Lévy market with an untradable stochastic factor. It is an open question proposed by Trybuła and Zawisza. Using the dynamic programming and Lagrange multiplier methods, we get the Hamilton-Jacobi-Bellman-Isaacs (HJBI) and Hamilton-Jacobi-Bellman (HJB) equations corresponding to the two investment problems. The equations are transformed into a new-type parabolic equation, from which the optimal strategies under both preferences are derived. We prove that the two optimal strategies and value functions coincide if and only if an important market assumption holds. When the assumption is violated, MMV investors act differently from MV investors. Thus, we conclude that the difference between continuous-time MMV and MV portfolio selections is due to the discontinuity of the market. In addition, we derive the efficient frontier and analyze the economic impact of the jump diffusion risky asset. We also provide empirical evidence to demonstrate the validity of the assumption in real financial markets.

Funding: This research was supported by National Natural Science Foundation of China [Grants 12271290 and 11871036].
Paediatric long-COVID diagnosis in school’s health unit environment
Authors: Mitera Blanka , Harasimowicz Karolina
Published: September 2024

It is known that the mental health and well-being of all children and young people should be taken care of, regardless of their SARS-CoV-2 infection status. It is difficult to know the exact number of young people who need help, but in many health systems the need is likely to be greater than the resources available. Many questions about long-COVID-19 in children and adolescents <18 years of age, its prevalence, natural course, risk factors, mechanisms and consequences remain unanswered. As well as studies assessing whether vaccination reduces the risk of long-COVID-19 in children and adolescents who contract COVID-19 despite vaccination would be valuable.
This paper examine the degree to which environmental elements were connected to children’s well-being during COVID-19 lockdowns and restrictions. The purpose of this study is to investigate early learning experiences in the family, childhood education and environmental elements that affect children’s social-emotional health. The results also show that there may be protective variables for kids’ mental health amid stressful situations, such the lockdowns that many families went through during the pandemic.

Keywords: long-COVID, mental health in children, COVID-19, vaccinations, pandemic.
The requirement to obtain the consent of a legal guardian for the provision of reproductive health pharmacist services to minors under the pilot program
Authors: Tomków Marek , Balwierz Radosław Jerzy , Majewski Adam , Szopa Aleksandra
Published: September 2024

Emergency contraception in Poland is often referred to as the “morning-after pill”. Its legal status has changed many times. In Poland, it has only been available on prescription since 2017. Attempts have been made to change the legal status in 2024. A draft amendment to the Pharmaceutical Act was then submitted to Parliament. However, the bill was vetoed by the President of the Republic of Poland. In response to the veto, the Minister of Health issued a decree on a pilot programme in the field of pharmacists’ services related to reproductive health. In connection with this regulation, a question arose for pharmacists: whether it is necessary to obtain the consent of the legal guardian of minors who want to use the programme. Therefore, the aim of the work was a legal-comparative and dogmatic-legal analysis of legal acts in the field of reproductive health. A review of the data shows that while the pharmacist carries out the activities indicated in the pilot programme for pharmacist services about reproductive health, health services are provided to patients. Therefore, in the case of minor patients under 16 years of age, or who are over 16 but under 18 years of age, the consent of their legal representatives is required. It should also be noted that the term “pharmacist service” used in the title is not defined in any way in the law (unlike the term “pharmaceutical service”) and does not constitute a definition that would allow the statement to be made that it is another unlisted activity that exempts the pharmacist from the obligation to obtain the consent of the legal guardian. It should therefore be assumed that this consent is necessary to provide the service.

Keywords: emergency contraception, pharmacist service, pharmaceutical service, legislation, morning-after pill.
The Effects of Community-Based Mental Health Program on Burden of Family Carers of Mentally Ill Pastient
Authors: Hah Yang Sook , Kim Susie , Kim Ki Sook , Park Hye Sook
Published: September 2024

This study was designed to testify the effects of Community-based mental health program on burden of family carers of mentally ill patient. The sample of this study consisted of 26 family carers whose mentally ill relatives were registered with a certain health center in Seoul and attending this program.The study was conducted for 1 year from the beginning of August 1996 to the end of August 1997.Subjective and Objective Burden Measurement was used to measure burden of family carer. This tool was originally developed by Montgomery (1985) and revised by researchers to 4-point Likert type scale. Data were collected three times : in month one, six, and twelve, and analyzed by SPSS PC + .During the program, burden of family carer was significantly reduced so that main hypothesis and three sub-hypothesis were all supported (main hy pothesis p==0.00, 1st sub-hypothesis p=0.00, 2nd p=0.00, 3rdp=0.001).In conclusions, Community-based mental health program can reduce burden of family carers by help ing them to continue their life and to function as a good support system for the chronic mentally ill relatives. The researchers, therefore, propose that this program should be extended to the other place and be supported by local and central government.
A comparative Study on Self-Efficacy of Day Hospital Patients and Psychiatric Out-Patients
Authors: Son Kyung Hee
Published: September 2024

This study is purposed to identify the difference of self-efficacy between day hospital patients and psychiatric out-patients.Data was obtained from 25 subjects who are members of day hospital and 27 subjects, out patients in psychiatric hospital.The period of data collection was from November, 24 to December 12, 1997.The results of this study was as follows :1. The day hospital patients had higher score of general and social self-efficacy than that of psychiatric out - patients (p<. 01).2. There were significant correlations between the period of treatment and general self-efficacy and social self-efficacy in day hospital patients(7=0.33, 7=0.24, p<.05).
The Perceptions and Attitudes of Lay Person toward the Mentally Ill
Authors: Gong SuJa
Published: September 2024

The purposes of the present study were to examine the collective perceptions and attitudes of lay person relying on the social representation theory.The sample consisted of 110 adults (44 men and 66 wemen). Data were obtained by asking the respondents to complete ten sentences, Which begin with the mentally ill is.The results were revealed as follows : 1. Lay person show a great dispositional accounts about the mentally ill.2. Lay person have not controllable factors the causal perception about mental illness,3. Lay person have negative feeling about the mentally ill.4. Lay person show a great accounts about the effects of mental illness.5. Lay person emphasis love and caring as well as socio - medical strateges.Overall, lay person have negative attitudes toward the mentally ill and mental illness. Correct and in-depth undestanding of lay persons* perceptions and attitudes will help us map out future directions and development the public mental health education programs. Findings of the study could serve as a baseline data developing the new prgrams for mental health education.
Application of Critical Paths in Mental Health Nursing Area
Authors: Lee Eun Sook
Published: September 2024

Recently, improvement of quality in medical services has become a subject of discussion and an important issue in Korea. So, healthcare organizations have been struggling to find ways of reducing medical costs with better medical results on the part of patients.Case Management is a delivery system of patient care of focusing on the achievement of specific outcomes within designated time frames and with appropriate use of resources. And this Case Man agement is called Critical Paths which are displayed in graphic form.Purpose of this study was to survey literature re view of critical paths for managing admitted psychiatric patients. Immediate goals of this study, in orders to accomplish the following areas will be studied ; 1) identifing principles and development process of critical paths, 2) finding the utilizing effect of critical paths in clinics, 3) identifing significance of development of critical paths in psychiatric nursing area, 4) identifing example of critical paths for psy chiatric patients, 5) identifing role of mental health nurse.Based on this study, it was found out that both of hospital based treatement and community based mental health program were proved to be important and necessary to connect botli program for keeping the balance.Most of critical paths were developed and applied ir.. hospitals at first and reported the common effects that were reducing length of stay and healthcare costs, and among othen things, improving communication between patients anc between healthcare team.Also, it was shown that critical paths could be expanded in community area as well as in clinical area, and be used as educational program for patients, families, student apprentice and staffs.Therefore, mental health nurses have to develop critical paths in order to improve quality of psychiatric care for both inpatients and outpatients care so that it should be able to serve as both case manager and coordinator through alliance and integration of both clinical and community case management.
The Stress Process of Caregivers who Care for the Mentally Ill Relatives
Authors: Kim Hee Jung
Published: September 2024

This paper views caregiver stress as a concequence of a process including a number of inter related factors : caregiver and patients* general characteristics, stress sources, mediators of stress, meni fest at ions of stress.Stress sources are distinguished into two factors including patients' psychiatric symptoms as first stressor and caregiver burden as secondary stressor Caregiver burden fall into two categories : objective burden experienced in roles and activities for the patient*s need and psychiatric svniptoms and subjec tive burden as a emotional reactions to the patient care and care environment. Resources and coping can potentially intervene at several points along the stress process. Resources comprise two factors :personal resource (mastery )and social support.
Self-Esteem and Related Factors of the Eged in the C city
Authors: Ahn Hwang Ran
Published: September 2024

Self-esteem is an essential component in health and the quality of life of the aged. But even though self-esteem among the aged has been documented in western country, few studies have been conduc ted related to the self-esteem in Korea. Especially, relationship of few the general characteristics and self-esteem has been studied in previous research and literature, but relationship of many variables (16) and self-esteem was studied in this study.The purpose of this study was to identify self-es teem and related factors of the aged m the C city.179 subjects were participated in the study. The sur vey questionaire was develoed by Hwang-Ran Ahn(1993).SPSS/PC + was utililized for data analysis and in cluded discriptive statistics, t —test, One way ANOVA. The results of this st udy are summerized as follows :1. Mean of self-esteem was 55.3, minimum was 31, and maximum was 76.2. Variables showed statistically significant differ ence in self-esteem of the aged were : sex, age.education, existence of spouse, family, occu pation, existence and type of intrest, personality, satisfaction of life, happiness of marriage, exist ence and type of disease. But it wasn’t signifi cantly different according to religion, existence of unmarried family, economic.From the results of this study, it can be concluded that the aged in the C city do have middle degree of self-esteem. And the 13 variables of 16 variables showed statistically significant difference in self-esteem. Therefore further research are needed to develop better selfesteem measurement tool to identify self-esteem of the aged and to develop and evaluate nursing intervention for high self-esteem.
Dual Diagnosis
Authors: Hyun Myung Sun
Published: September 2024

In recent years patients with dual diagnosis have increased m America. 'Dual diagnosis* or dual disorder are terms that have been used to indicate the coexistence of a mental heak:h disorder and substance use disorder. Patients with mental disorder are vulnerable to risk for substance use disorders, patients with substance use disorders are also vulnerable to risk for mental disorders. Even though there have been few people treated for dual diag nosis in Korea, there is need for concern about this diagnosis because a dual diagnosis makes the indi vidual more incapicitated. In Korea, several research papers have identified that personality disorders or depression coexisting with alcoholism.There are several possible relationships between substance abuse and psychiatric disorders. Substance abuse may induce, worsen, or diminish psy chiatric symptoms, complicating the diagnostic pro cess. Sometimes, the symptoms of coexisting psychiatric disorder may be misinterpreted as poor or incomplete recovery from drug addiction. In ad dition, psychiatric disorders may interfere with the patients’ ability and motivatior. to participate iri ad diction treatment.This article provided an overview of chai act.eristics and assessment based on a biopsychosocial model. Indeed, the treatments tor dual diagnosis are very complex and difficult and he prognosis for this disorder is very poor. In this article, pharmacologic and psychosocial treatment aie over viewed and a treatment model also is provided.Finally, it is suggested that nurses who mt t patients with mental disorceis or substance use disorders can have an importint role in detecting or preventing the occurrence of dual diagnosis.
Identifying Groundwater Recharge Sources and Mechanisms using Hydrochemistry and Environmental Stable Isotopes in High Arsenic Holocene Aquifers of Bangladesh
Authors:   School of Management, Yulin University, Yulin-719000, China, Huq Md. Enamul , Lopez-Carr David ,   Department of Geography, University of California, Santa Barbara, CA, USA, Almutlaq Fahad ,   Department of Geography, College of Humanities and Social Sciences, King Saud University, Riyadh 11451, Saudi Arabia, Wu Xijun ,   School of Civil Engineering, Yulin University, Yulin 719000, China, Wu Jiang ,   Department of Information Engineering, Yulin University, Yulin 719000, China
Published: September 2024

Und erstanding the sources and mechanisms of aquifer recharge is critical for water resource management. So far, this is the first comprehensive study to explore the sources and mechanisms of groundwater recharge applying stable environmental isotopes and hydrogeochemical properties in Southwestern Bangladesh. Water samples from the different sources (groundwater, surface (pond), river and rain water) of high arsenic (As) Holocene aquifers were used to investigate the chemical tracers and environmental stable isotopes (δ18O and δ2H) to explore the hydrogeological features, groundwater recharge sources, mechanisms and processes. The analytical results showed high As concentration in water samples observed 590.7 μg/L. High As groundwater was identified by a low pH value, medium HCO3- and TDS with low concentration of NO3- and SO42-. However, depleted δ2H and δ18O signatures indicated that local vertical rainfall is the key source to recharge groundwater in study area. The recharge process from pond seepage and irrigation return flow also contribute in groundwater recharge. Isotopic signatures suggested the vertical connectivity amongst the aquifers and significant vertical recharge. The reduced heavier isotope reveals extra recharging from floods of mountains and high altitude. Due to the heterogeneous and anisotropic structure of the aquifer system the spatial variability of δ2H and δ18O shows limited lateral connectivity. The combined analyses of δ2H isotope and Cl- ion showed that evaporation is the primary cause for groundwater discharge. Based on the spatial and vertical recharge processes of groundwater, present study provides a crucial baseline knowledge for establishing a sustainable groundwater management strategy. The findings from this study can guide the development of targeted groundwater management strategies and improvement of understanding the groundwater recharge sources and processes.
Cytoprotection Against Oxidative Damage by Bioaccessible Fraction of Unripe Musa balbisiana Fruit Extract in An Intestinal-like Epithelial Cell Model
Authors:   Department of Food Science and Nutrition, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Mueang Pattani 94000, Thailand, Tohteb Areeya , Kaewmanee Thammarat ,   Department of Food Science and Nutrition, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Mueang Pattani 94000, Thailand, Boonyanuphong Piyawan ,   Department of Food Science and Nutrition, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Mueang Pattani 94000, Thailand, Utaipan Tanyarath ,   Department of Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Mueang Pattani 94000, Thailand
Published: September 2024

T he fruit of Musa balbisiana (Tani banana) is an agricultural product that is not typically consumed due to its many seeds and small amount of flesh. However, studies have documented various biological activities, suggesting that this fruit could serve as a potential source of functional ingredients. This study produced M. balbisiana extract powder and investigated its cytoprotective effects against oxidative damage in an intestinal-like epithelial cell model in vitro. Unripe banana fruits were extracted using ultrasonic-assisted extraction, followed by spray drying to obtain a powder form. The non-digested extract (MBE) and digested extract (bioaccessible fraction; MBDE) were examined to determine their total phenolic content (TPC) and total antioxidant activities. For cytoprotection analysis, Caco-2 cells were cultured for 18 to 21 days to form an intestinal epithelium-like monolayer. The cell monolayers were then treated with MBE and MBDE (1000–5000 μg/ml) for 24 h, followed by H2O2 (5 mM) induction to induce oxidative stress. The cell viability, levels of intracellular reactive oxygen species (ROS), transepithelial electrical resistance (TEER), and interleukin-8 (IL-8) were determined. Results showed that MBDE at 5000 μg/ml resulted in 71.8% rescue of H2O2-induced cell death. The MBDE drastically decreased intracellular ROS levels by 6-fold compared to the H2O2-exposed cells. The MBDE significantly sustained the integrity of the cell monolayer, as demonstrated by the increasing TEER value, whereas IL-8 was not involved in this experimental condition. Findings suggested that the bioaccessible fraction of M. balbisiana fruit extract protected the intestinal epithelial-like cell monolayer from oxidative damage by ROS due to its antioxidant properties. Therefore, unripe fruit of M. balbisiana extract showed potential as a functional ingredient to increase antioxidant activity in the intestinal epithelium.