bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Enzymurian Activity on the Results of Ureterolithotyrispy in Patients with Ureterolytisis of a Uniform Disease
Authors: О. Л. Мороз
Published: May 2020

The work is devoted to the study of the state of enzymur activity in patients with ureterolithiasis of single kidney after various methods of ureterolithotripsy. It was established that the activity of renospecific enzymes of the tubular nephteraemia NAD and β-Gal reflects the functional state of the urinary tract before and after the minimally invasive intervention in the ureterolithiasis of the single kidney, which promotes the timely correction of therapeutic measures.
Analysis of Integrated ANC Services on the Satisfaction and Event of High Risk in Pregnantmother in Islamic Hospital Bangil Pasuruan
Authors: Sulistyawati Ety Diana , Suhita Byba Melda , Nurdina Nurdina
Published: May 2020

Maternal Mortality can be prevented by early detection of high risks or complications during pregnancy, by conducting prenatal checks into available health services. The high maternal mortality rate indicates that the quality of maternal health services that are still low includes antenatal care (ANC) services. The purpose of the study was to analyze integrated anc services for satisfaction and high risk events of pregnant women at Masyithoh Bangil Pasuruan Islamic Hospital. The research design used is quantitative research with a cross sectional approach. Instrument data used questionnaire sheets using Chi Square test and Ordinal Regression. The results of the analysis of chi square test between variables ANC services integrated with satisfaction of pregnant women obtained p-value 0,000 <0,05, meaning that there is a relationship between integrated ANC services to satisfaction of pregnant women at Masyithoh Bangil Pasuruan Islamic Hospital. Whereas between integrated ANC service variables with high risk events obtained p-value 0.015 <0.05, meaning that there is a relationship between integrated ANC services to the high risk incidence of pregnant women at Masyithoh Bangil Pasuruan Islamic Hospital. Based on the results of the Ordinal Regression Test analysis shows that the most influential variable with the Integrated ANC Service at the Masyithoh Bangil Pasuruan Islamic Hospital is the variable satisfaction of pregnant women with a p-value of 0,000 <0,05. It is expected that respondents can conduct an Integrated ANC on a regular basis and the service can remain satisfactory
The Influence of the Quality of Service and the Implementation of the Policy of Return Administration at Inpatient Room Towards Satisfaction of Third Class of BPJS Patient in Muhamadiyah University Hospitals at Malang
Authors: Maria Maria , Suhita Byba Melda , Peristiowati Yuly
Published: May 2020

The purpose of this research was to analyze the influence of the quality of service and the implementation of the policy of return administration at inpatient room towards satisfaction of third class of BPJS patient at RS UMM. Design of this research are analysis crossectional. Variable of the research are. the influence of quality of service and the implementation of the policy as the independent variable and patient satisfaction as the dependent variable BPJS. Population research namely inpatients who have been allowed to return home on October 15 – November 15, 2018 by the physician in question at the time when the last doctor's visit. Samples taken by random sampling technique as much as 92 respondents. The data collected by the instruments and questionnaires processed in coding, editing, tabulating and scoring as well as tested with linear regression test.

Linear regression results indicate that partially and the simultaneous values of p values there are shows so that 0.05 < influence the quality of services and the implementation of the policy to the satisfaction of the patient. he value of the coefficient of determination shows the value that shows contributions from 0.434 independent variable (the quality of service and policy implementation) amounted to 43.4%, while the remaining 56.6% in influence by other factors not present in the model This research. This happens because the factor that affect patient satisfaction is not only seen from the implementation of policies and the quality of services, but there is another factor that could affect such facilities or the attitude of the officers. Quality of service and implementation of the return of the patient affect the satisfaction of the patient. This happens because with the delay time return for the patient, or the patient's waiting too long is also the process of their return would cause a negative perception of the patient so that the patient feels accepted slow service
PERANGKAT LUNAK KOMPUTER WIWIK EMA BONITA
Authors: BONITA WIWIK EMA
Published: May 2020

Perangkat lunak (software) adalah perangkat yang tidak dapat dipegang dan dilihat secara langsung namun dapat dioperasikan dan dirasakan manfaatnya.Perangkat lunak komputer (software) merupakan sekumpulan data elektronik yang disimpan dan diatur oleh komputer, data elektronik yang disimpan oleh komputer itu dapat berupa program atau instruksi yang akan menjalankan suatu perintah. Perangkat lunak disebut juga sebagai penerjemah perintah-perintah yang dijalankan pengguna komputer untuk diteruskan atau diproses oleh perangkat keras. Melalui software atau perangkat lunak inilah suatu komputer dapat menjalankan suatu perintah.Software memiliki komponen-komponen yang saling bekerja sama membentuk satu kesatuan dalam menjalankan fungsinya. Komponen tersebut dibagi ke dalam tiga golongan yaitu, Sistem Operasi, Sistem Aplikasi dan Bahasa Pemograman.Sistem operasi merupakan program komputer yang berisi perintah-perintah yang bertugas menyelesaikan interaksi antara manusia dengan komputer, sehingga komputer dapat bekerja sesuai keinginan. Sedangkan sistem aplikasi adalah seperangkat intruksi khusus dalam komputer dalam menyelesaikan tugas-tugas tertentu. Bahasa program adalah suatu cara berkomun
Anti-Intellectualism and the Mass Public’s Response to the Covid-19 Pandemic
Authors: Merkley Eric , Loewen Peter John
Published: May 2020

Anti-intellectualism – the generalized distrust of experts and intellectuals – is an important concept in explaining the public’s engagement with advice from scientists and experts. We ask whether it has shaped the mass public’s response to COVID-19. We provide evidence of a consistent connection between anti-intellectualism and COVID-19 risk perceptions, social distancing, mask usage, misperceptions, and information acquisition using a representative survey of 27,615 Canadians conducted from March to July 2020. We exploit a panel-component of our design (N=4,910) to strongly link anti-intellectualism and within-respondent change in mask usage. Finally, we provide experimental evidence of anti-intellectualism’s importance in information search behaviour with two conjoint studies (N~2,500) that show respondents’ preferences for COVID-19 news and COVID-19 information from experts dissipate among those with higher levels of anti-intellectual sentiment. Anti-intellectualism poses a fundamental challenge in maintaining and increasing public compliance with expert-guided COVID-19 health directives.
Quantifying antibody kinetics and RNA shedding during early-phase SARS-CoV-2 infection
Authors: Borremans Benny , Gamble Amandine , Prager KC , Helman Sarah K , McClain Abby M , Cox Caitlin , Savage Van , Lloyd-Smith James O.
Published: May 2020

Our ability to understand and mitigate the spread of SARS-CoV-2 depends largely on antibody and viral RNA data that provide information about past exposure and shedding. Five months into the outbreak there is an impressive number of studies reporting antibody kinetics and RNA shedding dynamics, but extensive variation in detection assays, study group demographics, and laboratory protocols has presented a challenge for inferring the true biological patterns. Here, we combine existing data on SARS-CoV-2 IgG, IgM and RNA kinetics using a formal quantitative approach that enables integration of 3,214 data points from 516 individuals, published in 22 studies. This allows us to determine the mean values and distributions of IgG and IgM seroconversion times and titer kinetics, and to characterize how antibody and RNA detection probabilities change during the early phase of infection. We observe extensive variation in antibody response patterns and RNA detection patterns, explained by both individual heterogeneity and protocol differences such as targeted antigen and sample type. These results provide a robust reference for clinical management of individual patients, and a foundation for the mathematical models and serological surveys that underpin public health policies.
PERANGKAT LUNAK KOMPUTER
Authors: Fadhilah Adinda Ayu
Published: May 2020

Perangkat lunak komputer merupakan sebuah program komputer yang menjembatani pengguna komputer dan perangkat keras yang digunakannya. Dengan kata lain perangkat lunak merupakan penerjemah antara manusia sebagai orang yang memberi instruksi dan komputer sebagai pihak yang menerima instruksi. Perangkat lunak memang tidak tampak secara fisik dan tidak berwujud benda namun bisa untuk dioperasikan. Perangkat lunak secara garis besar software atau perangkat lunak dapat diklasifikasikan menjadi tiga bagian yaitu, perangkat lunak sistem operasi, perangkat lunak sistem aplikasi dan bahasa pemograman.Kata kunci : Perangkat Lunak KomputerAbstractComputer software is a computer program that bridges computer users and the hardware they use. In other words software is a translator between humans as the person who gives instructions and the computer as the party who receives instructions. The software does not appear physically and is not tangible but can be operated. Software outline software or software can be classified into three parts, namely, operating system software, application system software and programming languages.. Keywords: Computer Software
Happiness in the world? (Pascal before Port-Royal)
Authors: Akmut Camille
Published: May 2020

Various events and people in the life of Pascal during his ”worldly”period (here significantly revised, extended).
Efektivitas Penataan Ruang Parkir di Lingkungan Kompleks Kantor SKPD Kabupaten Sidrap
Authors: H Maryam , Said Lambang Basri , Nasruddin
Published: May 2020

Sidrap adalah satu-satunya kabupaten di Sulsel dengan konsep pemerintahan, seluruh Satuan Kerja Perangkat Daerah (SKPD) berada dalam satu kawasan. "Sehingga ini memudahkan masyarakat mengakses unit kerja satu dengan unit kerja lainnya karena berada dalam satu kompleks dimana ruang parkir yang tersedia tidak mencukupi untuk menampung banyaknya kendaraan yang ingin parker, karena kecilnya ruang parkir dibanding dengan jumlah kendaraan yang memerlukan tempat parkir sedemikian besar. Tujuan dilakukannya penelitian ini adalah untuk mengevaluasi karakteristik kebutuhan ruang parkir di lingkungan kompleks Kantor SKPD Kabupaten Sidenreng Rappang. Dalam penelitian ini, metode analisis data yang digunakan adalah metode analisis kualitatif. Data yang dikumpulkan secara lengkap dan telah dicek keabsahannya selanjutnya diproses dengan memperhatikan hasil survei lapangan mengenai kondisi ruang parkir. Berdasarkan hasil penelitian ini kondisi parkir dikomples SKPD Kabupaten Sidrap yang ada sekarang ini sudah sangat tidak efektif. Permasalahan parkir pada kompleks ini, luas parkir yang hanya mampu memarkir beberapa kendaraan sehingga sebagian pegawai dan pengunjung susahnya untuk memarkirkan kendaraannya dan adanya kantor-kantor tertentu yang bangkitan parkirnya cukup besar, sehingga tidak tertampung oleh fasilitas yang ada yang menyebabkan arus lalu lintas dikomples ini menjadi tidak lancar disebakan kemacetan di sepanjang ruas jalan. Diharapkan kepada pihak terkait dengan menyediakan lokasi parkir yang mencukupi untuk menampung kapasitas kendaraan yang ada serta menugaskan petugas parkir untuk mengatur parkir kendaraan para pegawai dan pengunjung yang datang mengurus dikomples ini untuk tidak memarkirkan kendaraannya di sembarang tempat, sehingga arus lalu lintas menjadi lancar.
Perangkat Lunak Komputer
Authors: Andini Zayla Agatri
Published: May 2020

Artikel ini mendeskripsikan hasil penelitian mengenai perangkat lunak komputer (software). Tujuan penelitian ini dilakukan untuk mengetahui 3 tingkatan perangkat lunak komputer.Metode yang digunakan dalam penelitian ini merupakan kunjungan ke suatu halaman world wide web (site visit) melalui beberapa link. Hasil penelitian menunjukkan bahwa 3 tingkatan perangkat lunak komputer yaitu tingkatan program aplikasi (application program misalnya Microsoft Office), tingkatan sistem operasi (operating system misalnya Microsoft Windows), dan tingkatan bahasa pemrograman (yang dibagi lagi atas bahasa pemrograman tingkat tinggi seperti Pascal dan bahasa pemrograman tingkat rendah yaitu bahasa rakitan). Hasil ini menunjukkan bahwa perangkat lunak secara garis besar dibagi menjadi 3 tingkatan umum yang menggambarkan fungsi dari masing-masing perangkat lunak saat mengendalikan maupun melakukan koordinasi antar perangkat keras yang ada pada komputer.
Perangkat komputer
Authors: mariani salsabila
Published: May 2020

Hardware merupakan salah satu komponen yang sangat mendukung dalam kinerja sistem komputer. Buku pintar digital hardware komputer berbasis multimedia dibuat dengan tujuan mempermudah pemakai komputer untuk mengenal dan memahami lebih detail perangkat-perangkat hardware komputer melalui informasi yang disajikan dalam bentuk teks, gambar,suara, video dan animasi.
Geospatial Data Analytics- A Deep Learning Perspective
Authors: Das Saneev Kumar , Bebortta Sujit
Published: May 2020

To visualize high-dimensional geospatial data has achieved much importance in last decades. But to analyze it, the technologies used of machine learning are not so convincing and thus it is high time to switch to a sub-domain of machine learning called deep learning, which has gained popularity because of its accuracy in processing and analyzing high-dimensional data. The convergence of deep learning with geospatial data analytics shall prove to be a boon to those who actually has a need to predict specific outputs over geospatial data. In this paper, we have presented some geospatial data generated using the GIS (Geographic Information Systems) technology and proposed ways to implement deep learning over these data. GIS technology is a mapping technology which signifies high-dimensional geospatial data and our aim is to propose a model where GIS converges with highly efficient deep neural networks such as CNN (Convolutional Neural Network), RNN (Recurrent Neural Network) and LSTM (Long Short-Term Memory Network). We have provided geospatial as well as statistical results in this paper to visualize practically the GIS technology. This paper further provides future scope of the proposed model which shall present the challenges that needs to be tackled in future and its applicability in many relevant domains.
Applying Social Psychology Theories to the Challenges of Harmonising Insolvency Law in the European Union
Authors: Ghio Emilie , Galvin John
Published: May 2020

Laws differ from one country to another in the European Union. When legal diversity is perceived as a problem, notably for the integration of the Internal Market, harmonisation is used as a tool to increase the similarity of legal rules. However, legal harmonisation in the EU can be a challenging task. Familiar arguments against legal harmonisation include the protection of national sovereignty, the preservation of legal cultures and the superiority of regulatory competition. These arguments have been studied extensively in the literature. This paper takes a novel approach by providing a perspective from the field of social psychology to further our understanding of the challenges of legal harmonisation in the EU. We adopt a case study method and focus on the specific area of European insolvency law to provide specific examples of how psychological biases have influenced the harmonisation process
Motivational effects on empathic choices
Authors: Ferguson Amanda M , Cameron Daryl , Inzlicht Michael
Published: May 2020

Empathy often feels automatic, but variations in empathic responding suggest that, at least some of the time, empathy is affected by one’s motivation to empathize in any particular circumstance. Here, we show that people can be motivated to engage in (or avoid) empathy-eliciting situations with strangers, and that these decisions are driven by subjective value-based estimations of the costs (e.g., cognitive effort) and benefits (e.g., social reward) inherent to empathizing. Across seven experiments (overall N = 1,348), and replicating previous work (Cameron et al., 2019), we found a robust empathy avoidance effect. We also find support for the hypothesis that individuals can be motivated to opt-in to situations requiring empathy that they would otherwise avoid. Participants were more likely to opt into empathy-eliciting situations if 1) they were incentivized monetarily for doing so (Experiments 1a and 1b), and 2) if a more familiar and liked empathy target was available (Experiments 2a and 2b). Framing empathy as explicitly related to one’s moral character and reputation did not motivate participants to engage in empathy (Experiment 3a and 3c), though these null results may be due to a weak manipulation. These findings suggest that empathy can be motivated in multiple ways, and is a process driven by context-specific value-based decision making.
The Perception of Infection Risks during the Early and Later Outbreak of COVID-19 in Germany: Consequences and Recommendations
Authors: Glöckner Andreas , Dorrough Angela Rachael , Wingen Tobias , Dohle Simone
Published: May 2020

In three studies (N = 1,055), we investigated the determinants and consequences of the perception of infection risks during the early and later outbreak of COVID-19 in Germany. Individuals’ perceived COVID-19 infection risk was reasonably in line with experts’ assessment but changed over time. The probability of the rare event of getting severely sick and hospitalized was overestimated. Overestimation increased in the exponential growth phase of the pandemic and later on decreased again, showing an inverse U-shaped pattern. Individuals showed biases in their risk perception concerning overconfidence and the underestimation of exponential growth of infection cases in the early phase of the pandemic. Forecasts were more accurate after the growth curve had flattened. Risk perceptions increased with perceived dread and tended to increase with perceived control over infection, the evaluation of scientific and own knowledge about the pandemic. Approval for the introduction of stricter governmental measures and acceptance of future vaccination measures was mainly influenced by rational utilitarian factors of risk perception (probabilities and utilities of outcomes). These rational influences were mediated by dread, but dread had an additional potentially irrational effect. Adherence to governmental recommendations was mainly driven by dread and positive expected long-term consequences of the measures. To a smaller degree, adherence increased with perceived personal consequences of infection and decreased with negative expected short-term consequences of these measures. Implications for theory development are discussed and recommendations to handle virus outbreaks are derived.
EFFECT OF ADDITION OF DIFFERENT NITRATE CONCENTRATION ON Spirulina platensis BIOMASS WITH SEMI OUTDOOR SYSTEM
Authors: Natalia Natalia , Amin Bintal , Effendi Irwan
Published: May 2020

Spirulina platensis is one type of microalgae that has high nutrient and protein content and can live in fresh and marine waters. In the growth of S. platensis requires several supporting factors in its growth period, one of which is nitrate (NO3). Nitrate is needed in the formation of proteins and amino acids in cells and also helps in increasing biomass. This study was conducted with the aim to see the effect of adding different nitrate concentrations to S. platensis biomass with a semi-outdoor system. This research was conducted in MarchApril 2019 using the experimental method. Water quality parameters during the study obtained in the form of temperatures ranging from 29 – 30oC, pH 9 and salinity 25 ppt. The optimum nitrate concentration for the growth of S. platensis was at a concentration of 9 ppm with a total biomass of 0.669 grams.
MANGROVE FOREST EFFECT ON THE COASTLINE IN RANGSANG ISLAND RIAU PROVINCE
Authors: Paulinus  , Mubarak Mubarak , Efriyeldi Efriyeldi
Published: May 2020

The study was conducted in May-June 2019 on Rangsang Island. This study aims to determine the effect of mangrove forests on coastline found on the island of Rangsang in Riau Province. The sampling location was determined by purposive sampling, namely 3 station points, namely Segomeng Village, Tanjung Kedabu Village, and Sungai Gayung Kiri Village. Landsat image data analyzed at the Oceanographic Physics Laboratory of the Department of Marine Sciences, Faculty of Fisheries and Maritime Affairs, University of Riau. To find out the area of ​​mangroves using Landsad 5 TM satellite imagery and Landsat 8 OLI Tirs imagery and analyzed using Er Mapper Software, Envi 4.5 and Arcgis 10.3. Calculation of the structure of the mangrove community is carried out using the line plot plot method. The results of the analysis of the vast landsat image of mangroves in the coastal areas of Rangsang Island in 1997, 2002, 2007, 2013, 2019 were respectively 11,093 ha, 10,807 ha, 10,393 ha, 10,121 ha and 9,971 ha. Changes in the coastline indicate the occurrence of abrasion and accretion, where the highest abrasion occurs at station three with an average of -7.6 m/year and accretion occurs at station one with an average of 2.68 m / year. Mangrove density at station one is 2266.7 ind / ha and at station two that is 1466.7 ind / ha. Mangrove species found were Rhizophora apiculata, Rhizophora mucronata, Avicennia alba, Sonneratia ovata, Bruguiera gymnorrhiza, and Xylocarpus granatum.
Anesthetic management in parturients with kyphoscoliosis
Authors: Thakur Jay Prakash , Gurung Tara , Shrestha Sangeeta , Basnet Ujjwal , Pradhan AP
Published: May 2020

Pregnancy in kyphoscoliotic woman is uncommon, with a reported incidence of 0.072%. It produces significant challenges for both anesthesiologist and obstetrician. Dealing with dual life, there is risk for both mother and fetus due to alterations in maternal physiology and change in spine anatomy. There are many case reports available with successful management both using spinal or general anesthesia. Here we present four case reports of successful management of such cases using general anesthesia or spinal anesthesia with palpatory and ultrasound guided method during a period of 6 months in Paropakar Maternity and Women’s Hospital.
Veterinary Student Opinions Regarding Ethical Dilemmas Encountered by Veterinarians and the Benefits of Ethics Instruction
Authors: Kipperman Barry , Rollin Bernard , Martin Jessica
Published: May 2020

Recognizing and addressing ethical conflicts is an emerging concern for veterinarians. Veterinary students ( N = 284) from four US schools were surveyed regarding their opinions on ethical dilemmas encountered by veterinarians and the benefits of ethics instruction. The majority of respondents had encountered all clinical scenarios that may be associated with ethical dilemmas that were provided. The most common ethical dilemma experienced was compromise of patient care because of financial limitations. Students with at least 12 months of experience were more likely to believe that practitioners encounter ethical dilemmas regularly. Although 92% of 271 respondents indicated that veterinarians should prioritize patient interests when the interests of clients and patients conflict, 84% of respondents reported that veterinarians most often prioritize client interests. Most (78%) respondents indicated having received training in ethical theories and approaches to address ethical dilemmas. The majority of respondents agreed that they feel better prepared to identify (80%) and address (55%) ethical dilemmas as a result of their ethics training. Most respondents (81%) identified experiencing moral stress in relation to how animals were treated. Only 46% of respondents reported receiving training in tools for coping with moral stress. Most of these respondents (54%) agreed that such training would be effective in helping to manage moral stress. Results suggested that educators should prepare students for the contrast in advocacy preferences they are apt to encounter when they enter practice. It is recommended that ethics training and tools for coping with moral stress be core components of the veterinary curriculum.
Revisión sistemática del carcinoma basocelular
Authors: Álvarez Castillo Andrey , Rodríguez Alfaro José Mario , Salas Boza Alicia
Published: May 2020

El cáncer de piel representa el tumor maligno más frecuente a nivel mundial, siendo el carcinoma basocelular el tipo más frecuente de neoplasia cutánea. Esta tumoración se origina de la capa basal de la epidermis o del bulbo del folículo piloso, y su patogenia ha sido investigada cada vez más con el paso de los años debido al incremento en la incidencia. Se han identificado los factores de riesgo de mayor relevancia y una serie de mutaciones en algunos genes supresores de tumores y alteraciones en la vía de señalización Hedgehog; ambas situaciones vinculadas con su patogénesis. En la actualidad, se cuenta con herramientas diagnósticas fácilmente accesibles que permiten una detección más temprana y oportuna de la enfermedad. Sin embargo, dicha neoplasia cutánea continúa generando un problema de salud pública considerable por su importante morbilidad e incidencia, lo que conduce a un elevado costo económico en el área salud.
Estestvennonauchnyi muzei kak faktor formirovaniia nauchno-filosofskogo myshleniia studenta (k 65-letiiu MZ MGU im. M.V. Lomonosova)
Authors: Sabodina Evgeniya Petrovna , Melnikov Yuriу Sergeevich
Published: May 2020

The role of the museum display of the Natural Zoning and Soil Formation Department of the Space Earth Science and Sustainable Nature Management Sector of the Landholding museum of M.V. Lomonosov Moscow State University in the formation and development of the scientific conceptual apparatus of students and schoolchildren of the last stage of education is discussed. The scientific and artistic forms of providing the provisions of science are revealed. The role of scientific and philosophical creativity of V.I. Vernadsky, V.V. Dokuchaev, G.V. Dobrovolsky, Yu. K. Efremov, E.D. Nikitin, V.P. Belov in the educational process is shown on the example of the display. The importance of some fundamental provisions of the Russian science of the XX – early XXI centuries in the formation of scientific and philosophical outlook of visitors of the Landholding museum of M.V. Lomonosov Moscow State University is pointed out.
Amberlite IR-120H Catalyzed Synthesis of 1,3-Diphenylpyrazolechromenoquinolin-6-one Compounds and Their Biological Evaluation
Authors: Kumar C. Ganesh , Kamal Ahmed , Nagaraju Burri , Kumar C. Ganesh , Kovvuri Jeshma , Gour Jitendra , Mullagiri Kishore , Nagesh Narayana , Routhu Sunitha Rani
Published: May 2020

A series of 1,3-diphenylpyrazole-chromenoquinolin-6-one compounds were designed and synthesized by
using a greener and recyclable heterogeneous Amberlite IR-120H resin as a catalyst, in the presence of
ethanol reflux conditions. Interestingly, the catalyst can be recovered after completion of the reaction and
can be reused without loss of catalytic property. Therefore, this method provides a green and
environmentally benign much improved protocol for the synthesis of 1,3-diphenylpyrazolechromenoquinolin-6-one compounds. The synthesized library of thirty compounds were tested against their
cytotoxicity; moreover, the compounds 5s and 5t exhibited potential cytotoxic activity with IC50 values of
1.22 and 1.64 µM, respectively, on MCF-7 cancer cells. The biophysical studies such as UV-visible,
fluorescence and circular dichroism studies indicate that these compounds possess good DNA intercalation
ability. In addition, these compounds efficiently inhibit topoisomerase I activity. Molecular docking and
viscosity studies support that these compounds exhibited intercalative mode of binding with DNA.
3D Printing Aided Elbow Deformity Correction
Authors: Vaish Abhishek , Johar Aamir , Vaish Abhishek , Maini Lalit , Vaishya Raju
Published: May 2020

Introduction: Fracture of lateral condyle of humerus is known for nonunion, if not treated properly in
children, often leads to a cubitus valgus deformity. For the late presenting cases with deformity and
restricted range of motion, surgical management is often challenging, and an appropriate preoperative
planning is required.
Case Report: We report a case of an un-united fracture of the lateral condyle of the humerus in an adult
with a cubitus valgus deformity with early tardy ulnar nerve palsy. He was treated by corrective osteotomy
with bone grafting of the nonunion and internal fixation with contoured plates. A virtual preoperative
surgical planning was done using 3D printing to define the exact location and direction of the osteotomy,
plate contouring and likely place of screw placement to achieve full correction of the elbow deformity.
Results: There was good correction of deformity, with union of the nonunion and osteotomy, at three
months follows- up. At one year, there was complete recovery of ulnar nerve palsy with excellent function
of the elbow and hand.
Conclusion: 3D printing is effective in treating complex orthopedic cases and deformity correction. Virtual
preoperative surgical planning on the computer and on a 3D model help to study the exact site of osteotomy,
plate contouring and screw placement to achieve accurate correction of the deformity. Virtual preoperative
planning and 3D printing help in reducing the surgical time and help to achieve desired correction of the
deformity.
Impact of Treatment Time on Outcome for Resected Head and Neck Squamous Cell Carcinoma by HPV Status
Authors: Watkins John M. , Snow Anthony N. , Anderson Carryn M. , Watkins John M. , Buatti John M. , Andresen Nicholas S. , Pagedar Nitin A. , Bayon Rodrigo , Mott Sarah L.
Published: May 2020

Background and Purpose: Prior investigations have demonstrated an inverse correlation between the
interval from resection of head and neck squamous cell carcinoma (HNSCC) to radiotherapy (RT)
completion (overall treatment time; OTT) and disease control. However, the importance of OTT in human
papillomavirus (HPV)-associated HNSCC remains to be determined. This study evaluates whether OTT
remains independently associated with cancer control when evaluated by HPV association.
Material and Methods: The data of HNSCC patients treated with curative-intent surgical resection
followed by RT were collected. Univariable and multivariable analyses were used to assess the effects of
HPV association and OTT.
Results: From 2002-2014, 73 eligible patients were identified (36 HPV-associated). The median OTT was
94 days (range, 69-185, with no difference between HPV subgroups). At a median follow-up of 34.9 months
(range, 2.6-162.2), 21 patients experienced disease failure, and 25 died. HPV-association was linked to
improved disease-free survival (DFS), disease-specific survival (DFS), and overall survival (OS) by
univariable and multivariable analyses. OTT was associated with improved DFS by univariable and
multivariable analyses.
Conclusion: OTT remains significantly associated with cancer control in the setting of HPV-associated
disease. Efforts should be made to minimize the delay between resection and completion of RT for all
HNSCC patients.
Ethical Calculus for the Provision of Dental Care during and after the COVID-19 Pandemic of 2020
Authors: Govind Akshay , Govind Akshay
Published: May 2020

Background: Due to its high rate of spread and unpredictable course, the COVID-19 virus has limited
dentistry to providing only urgent treatment through the pandemic of 2020. With time, the burden of
untreated dental disease will slowly rise, but too early a return to elective treatment will contribute to the
spread of coronavirus and under-utilize much needed PPE, causing undue morbidity and mortality.
Methods: A theoretical framework is proposed for calculating a safe return to work for dental providers in
the United States after the COVID-19 pandemic. Clinical, ethical, economic, and mathematical principles
are utilized.
Results: A model is offered using the concept of QALYs and DALYs to calculate benefits and risks of
dental care. The model includes a 13-variable formula that takes into account the prevalence and impact of
dental disease and the novel coronavirus.
Practical Implications: Organized dentistry groups are encouraged to couple clinicians and policymakers
to calculate the optimal timing for a measured return to work. Specifically, a safe return will balance PPE
supply and efficacy with hospital capacity to find an optimal prevalence of COVID-19 and dental disease
where it would be most responsible for dentists to return to providing elective care. Lastly, a call is made to
lobby for government support for dentists, as dental care is a vital service to the public provided almost
entirely by a private sector workforce in the United States.
Emotional Burnout in the Higher Education Teachers as a Health Risk Factor and a Cause for Leaving the Profession
Authors: Anatolyevna Lisnyak Marina , Andreyevna Gorbach Natalia , Anatolyevna Lisnyak Marina , Iurievna McCaw Tatiana
Published: May 2020

Introduction: Emotional burnout occurs more often in people employed in altruistic professions, including
teaching.
Purpose: Carry out research to identify emotional burnout in higher education teachers and its influence on
their health.
Methods: Psychological, statistical and analytical. With the questionnaire of V. Bojko “Emotional
burnout”, 637 people were surveyed, including a group of 60 teachers. Data gathered were processed and
analysed using descriptive and analytical statistics.
Results: Among teaching staff, the phase of stress was determined in every fourth teacher (26,6 ± 5,7 %).
For 8,3 ± 3,5 % of teachers, the phase of stress was already developed, while for 18,3 ± 4,9 % of teachers it
was still in development. The symptom “Reduction of professional responsibilities” was identified in half
of the teachers (50,0 ± 6,4 %), which is 3,5 times more frequent than for the whole sample (14,4 ± 0,4 %),
p < 0,05. The symptom “Expansion of emotion saving” was also more frequently observed in teachers:
31,6 ± 6,0 % and 11,5 ± 0,4 %, p < 0,05 respectively. Particular emphasis should be placed on the symptom
“Psychosomatic and psychovegetative disorders”, which was identified in every tenth examinee
(13,3 ± 4,3 % in teacher sample and 9,7 ± 0,3 % in total sample, p > 0,05), which can affect their somatic
well-being and their work capacity.
Conclusion: Emotional burnout should be considered as a health risk factor, especially for higher education
teachers, which requires development and implementation of measures to prevent the loss of highly
qualified human resources.
Descending Aorta Finger Clamping to Control Intra-Abdominal Bleeding Due to Rupture of Anterior Superior Pancreaticoduodenal Artery Aneurysm
Authors: Takemura Nobuyuki , Mihara Fuminori , Ono Hayato , Wake Hitomi , Yano Kaito , Ito Kyoji , Takemura Nobuyuki , Kokudo Norihiro
Published: May 2020

Background: Open aortic cross-clamping via a resuscitative left thoracotomy is effective in maintaining
adequate blood pressure in patients with abdominal bleeding until achieving hemostasis. However, the
procedure to encircle the descending aorta to secure cross-clamping is technically demanding for general
surgeons, especially in emergency situations.
Case Presentation: We report a case of rupture of the anterior superior pancreaticoduodenal artery
aneurysm associated with median arcuate ligament syndrome, which required surgical hemostasis. Because
of severe hypotension after laparotomy, open aortic cross-clamping with a left thoracotomy was performed
by general surgeons. However, the aortic clamps repeatedly slipped off because the clamping was conducted
without encircling the aorta. Then, we attempted finger clamping of the descending aorta, and the blood
pressure was quite effectively stabilized.
Conclusion: Descending aorta finger clamping via a resuscitative left thoracotomy is easy and feasible and
might be an effective procedure to maintain adequate blood pressure for general surgeons.
Incidence and Risk Factors of Recipient Surgical Site Infection in Oral and Maxillofacial Reconstruction with Vascularized Fibular Bone Grafts
Authors: Vittayakittipong Pichai , Makmanee Sarocha
Published: May 2020

Objective: To determine the incidence and risk factors of recipient surgical site infection (RSSI) after oral and maxillofacial reconstruction with vascularized fibular bone grafts (VFBG).Material and Methods: This retrospective study was performed in patients who underwent oral and maxillofacial reconstructive surgery, with VFBG, at the Dental Hospital, Faculty of Dentistry, Prince of Songkla University. Demographic, preoperative, intraoperative and postoperative data were recorded. Any infection at the recipient site occurring within 30 days post-operatively, by criteria from the Center of Disease Control, was defined as RSSI. Statistical analysis was performed by chi-square test, Student's t-test and Pearson’s correlation coefficient with statistical significance was set at 0.05.Results: There were twenty-one patients who met the eligibility criteria. The incidence of RSSI after oral and maxillofacial reconstruction with VFBG was 47.6% (10/21 patients), and the success rate of VFBG was 95.2%. American Society of Anesthetics (ASA) physical status class II and oral contamination were significant risk factors for RSSI (p-value=0.004 and p-value=0.031, respectively). Length of hospital stay was significantly higher in the RSSI group (p-value<0.001).Conclusion: The incidence of RSSI after oral and maxillofacial reconstruction with VFBG was high, and ASA physical status class II and oral contamination were significant risk factors for RSSI.
Entrepreneurial Disposition in Brazilian University Students
Authors: Dutra Lelayne de Araújo , Queiroz Jamerson Viegas , Queiroz Fernanda Cristina Barbosa Pereira , Lima Nilton Cesar , Marques Eduardo Lopes
Published: May 2020

Higher education is universally recognized as a key pillar in the construction of new knowledge economies. The Brazilian university, in general, does not explore its potential to inspire and stimulate students' ambition and innovation. Is there any neglect in the willingness of young university entrepreneurs to promote economic development and consolidate knowledge transfer? This study aims to analyze how the entrepreneurial intention of Brazilian university students behaves. The field of investigation is the Junior Companies of the country, whose use of the Modeling of Structural Equations represents the method of investigation. The study met the statistical criteria for its validation, in addition to presenting a moderate adjustment index explaining 64.9% of the entrepreneurial intention with only one rejected hypothesis. The findings of this research suggest gaps in the performance of government and universities in promoting entrepreneurial education and have implications for entrepreneurship scholars, universities, and policy makers.
Bureaucratic Manacles in Financial Autonomy of Public Hospitals in Pakistan
Authors: Iftikhar Ifra , Butt Abbas  Rashid , Shehzad Sobia , Riaz Sohail
Published: May 2020

The objectives of financial autonomy aimed to reduce government commitments in the financing of public hospitals, to increase efficiency in hospital operations, contain costs, and raise the quality of care. The present survey study of Allied Hospital Faisalabad explores that bureaucratic manacles in financial autonomy of these public hospitals end up in creating low job satisfaction levels among the employees of the hospitals. The dissatisfaction among Doctors, Nurses, Paramedical Staff, and Surgeons towards the management of the hospital was observed. , and irregular flows causes low levels of satisfaction in patients towards doctors, nurses and paramedical Staff.
Anxiety disorder and consumption of social media in Brazil
Authors: Torres Silva Tarcisio
Published: May 2020

Brazilian population spends a lot of time on social media. The average access from any device is 3 hours and 39 minutes (The Global, 2018). On the other hand, the country leads the numbers of anxiety disorder among the population. According to the World Health Organization, the incidence in the country is 9.3%, while the world average is 3.5%. This number is even higher in big cities, reaching 19.9% in the city of São Paulo (Horta, 2019). Possible causes are economic instability, social changes and violence (Horta, 2019). Add to that the political polarization in recent years and the intensive use of gadgets, private chat applications, such as Whatsapp, and social networks. In this work, we focus on the influence of social networks in the development of Brazilian anxiety. Our hypothesis is that the intensity of use reinforces the existence of other factors of anxiety increase (economy, violence, political division, etc.) through the sharing of news, besides adding others, such as self-display, performativity and the need of always being in evidence in social networks. As a method, we will work with content analysis (news and images) from the main social networking platforms used in Brazil.
Procedural Justice as an Approach to Address Workload among Kindergarten Supervisors, Minia Governorate
Authors: Latif Tahany Shehata Ahmed Abdul , Ghobish Nasser Foad Ali , El-Azab Hany El-Sayed Mohamed
Published: May 2020

The current research aimed at identifying the level of procedural justice and workload among kindergarten supervisors at Minia governorate, and identifying the relationship between procedural justice and workload. For data collection, the researcher applied a questionnaire to a sample of (36) kindergarten supervisors, Minia governorate. Results revealed that there was a statistically significant correlative relationship between the level of procedural justice and workload reflected in the workload of kindergarten supervisors. Therefore, the study recommended providing a suitable climate for practicing procedural justice, paying attention to the professional development of kindergarten supervisors, providing material and moral encouragement for kindergarten technical supervisors, providing means of transportation between kindergartens especially in the countryside, and activating the system of promotions inside kindergartens.
Invasive neuromonitoring with an extended definition of delayed cerebral ischemia is associated with improved outcome after poor-grade subarachnoid hemorrhage
Authors: Veldeman Michael , Albanna Walid , Weiss Miriam , Conzen Catharina , Schmidt Tobias Philip , Schulze-Steinen Henna , Wiesmann Martin , Clusmann Hans , Schubert Gerrit Alexander
Published: May 2020

OBJECTIVE

The current definition of delayed cerebral ischemia (DCI) is based on clinical characteristics precluding its use in patients with poor-grade subarachnoid hemorrhage (SAH). Additional concepts to evaluate the unconscious patient are required. Invasive neuromonitoring (INM) may allow timely detection of metabolic and oxygenation crises before irreversible damage has occurred.

METHODS

The authors present a cohort analysis of all consecutive SAH patients referred to a single tertiary care center between 2010 and 2018. The cohort (n = 190) was split into two groups: one before (n = 96) and one after (n = 94) the introduction of INM in 2014. A total of 55 poor-grade SAH patients were prospectively monitored using parenchymal oxygen saturation measurement and cerebral microdialysis. The primary outcome was the Glasgow Outcome Scale–Extended (GOSE) score after 12 months.

RESULTS

With neuromonitoring, the first DCI event was detected earlier (mean 2.2 days, p = 0.002). The overall rate of DCI-related infarctions decreased significantly (from 44.8% to 22.3%; p = 0.001) after the introduction of invasive monitoring. After 12 months, a higher rate of favorable outcome was observed in the post-INM group, compared to the pre-INM group (53.8% vs 39.8%), with a significant difference in the GOSE score distribution (OR 4.86, 95% CI −1.17 to −0.07, p = 0.028).

CONCLUSIONS

In this cohort analysis of poor-grade SAH patients, the introduction of INM and the extension of the classic DCI definition toward a functional dimension resulted in an earlier detection and treatment of DCI events. This led to an overall decrease in DCI-related infarctions and an improvement in outcome.
Imaging Findings in Dorsal Thoracic Arachnoid Web and the Differential Diagnosis of “Scalpel Sign”
Authors: Brasil P.M. , Pereira L.P. , Távora D.G.F. , Camara A.C.F. , Macedo Filho C.L. , Coimbra P.P.A.
Published: May 2020

A dorsal thoracic arachnoid web represents an intradural extramedullary transverse band of arachnoid tissue that causes mass effect and dorsal cord indentation, and can or cannot be associated with spinal cord altered signal. On sagittal MR imaging, this focal dorsal indentation of
the thoracic spinal cord resembles a scalpel with its blade pointing posteriorly (called a “scalpel sign”). Although very suggestive of dorsal thoracic arachnoid web, this sign is not specific and should be differentiated from other ventral cord displacement causes (eg, idiopathic
spinal cord herniation and spinal arachnoid cyst). In idiopathic spinal cord herniation, cord tissue protrudes through a ventral dural defect, and the focal deformity can be seen along the ventral aspect of the cord on spinal axial MR imaging and with a characteristic “C sign”
on sagittal MR imaging; in spinal arachnoid cysts, the marginated walls and the presence of smooth, wide scalloping of the cord surface can be identified. Recognition of these imaging findings, especially the scalpel sign, can help radiologists and clinicians make a correct diagnosis of ventral
cord displacement causes and allow subsequent prompt treatment for the patient.
Current Planning for Internal Audit of Risk Assessment of the Company Activities
Authors: SHYGUN М.
Published: May 2020

Lack of management control of the activity risks creates critical operating conditions for the enterprise, in which the financial indicators may change unexpectedly and unfavorably. Avoidance of the risks of an entity's activity is possible if effective interaction is made primarily between economic security and internal audit departments. Productive work of internal auditors to identify, evaluate and reduce the impact of risks on the performance of the enterprise is possible with its proper organization. The article describes the key principles for planning the activities of internal auditors to ensure the quality of audit procedures. Approaches to the organization and planning of the Internal Audit Department's work on identifying risks of the entity's activities, minimizing them and preventing them in the future are disclosed. A working plan for the application of audit procedures in the department of accounting, cashier and warehouse is presented, which demonstrates procedures for identifying and assessing such types of risks as market, payment, currency, financial, tax, credit, loss of assets. The working plan of the audit procedures developed contains the most effective procedures, depending on the objects of the audit, determines the scope of the audit, the procedure of its carrying out, responsible executors, the terms of the procedures. The use of the following suggestions for the planning of internal audit allows to apply qualitatively different forms and methods of audit, types of audit procedures, specialize the audit activities, correctly establish the order of audits, take into account the results of audit in the preparation and approval of various types of enterprise reports.