bluuebunny/crossref_metadata_2025 huggingface dataset:
CO-OPERATION BETWEEN TOURISM ENTERPRISES AS THE SOURCE OF NEW TOURISM PRODUCT CREATION
Authors: Lipianin-Zontek Ewa , Zontek Zbigniew
Published: November 2017

Purpose – This paper reports on an empirical analysis of co-operation initiatives to create new tourism products. It suggests possibilities for new tourism product creation through local cooperation processes, and, via an exploratory study, analyses existing levels of co-operation initiatives and their impact in Poland. Design – The paper gives a theoretical overview of tourism cluster co-operation theory, and its effects on new product creation. Analysis of exploratory data on tourism enterprises operating in Polish clusters, then identifies their current state of co-operation, and suggests ways to predict future co-operation levels, especially in particular tourism product groups. Methodology – After extensive review of published literature, the authors researched tourism enterprises via a questionnaire surveying tourism enterprises in Poland. The research was exploratory in nature, however the small sample gave useful results, both quantitative and qualitative. Findings – Published research on clusters and co-operation has had limited application in tourism. This exploratory study extends it significantly. Tourism companies definitely perceive the value of co-operation in creating tourism products. They have co-operated to a limited extent in the past, and are now committed to intensify this. To succeed it is necessary to promote trust, co-operation and partnership amongst them, within their own sector, and in related spheres such as public bodies. The nature of co-operation in tourism fits well with the concept of clusters. Originality of the research – This study provides a new contribution because prior Polish cooperation studies are few in number.
WHAT MAKES THE THEATRE AUDIENCE RETURN? THE ROLE OF ENGAGEMENT IN PREDICTING FUTURE BEHAVIOR
Authors: Pap Ana , Dlačić Jasmina , Ham Marija
Published: November 2017

Purpose – The purpose of this research is to explore the factors that influence the future behaviour of theatre audience. The authors hypothesized that the audience engagement could be the key factor and the answer to the question: What makes the theatre audience return? Methodology – The research was conducted on a sample of 537 respondents from Croatia that have visited either Croatian National Theatre in Osijek or in Rijeka in the past two years. This precondition was ensured through filter question on the beginning of the survey and 452 respondents have satisfied the precondition. The data was gathered through highly structured questionnaire designed based on scales and items adapted from previous research. Structural equation modelling (SEM) in LISREL was used to analyse the data. Findings – Research results suggest that future behaviour of theatre audience is positively influenced by perceived value of theatre performances and customer engagement. Contradictory to previous findings, quality of performance has no influence on future behaviour. Also, mediator effects are explored. Managerial implications are discussed and suggestions for marketing managers in theatres offered. Originality of the research – This research contributes to the development of the theory on customer engagement in general and in the context of non-profit marketing as well as theatre marketing. It provides the empirically based answers to research questions related to the predictive power of engagement as well as other suggested variables. The study also contributes to understanding the determinants of future behaviour of theatre audience in Croatia
CURRENT FEATURES OF TOURISM EMPLOYEES IN CROATIA
Authors: Bartoluci Mato , Ferjanić Hodak Danijela
Published: November 2017

The complexity and fragmentation of tourism leads to the question whether and to what extent is possible to determine the exact number of employees that can be attributed to tourism, which is the reason for choosing this topic for the research. First aim of the paper is to explain the complexity of labour force in tourism. Paper includes comparative analysis of tourism employment in Croatia and EU 27 countries. Second aim of the paper is to reexamine features of tourism employees: high seasonality, higher average age of employees, lower level of education, and higher share of employed women, which represents the main research question of the paper. Results and findings of the paper are based on the secondary research. Used research methods include: analysis of the existing theoretical and practical findings, the analysis of the relevant research findings available from secondary data sources, analysis of selected cases and case comparisons and descriptive statistics for the data analysis. The findings of the research showed constant growth in number of persons employed in accommodation and food service sector, both in Croatia and EU 27 countries. Total employment in EU 27 countries in analyzed period has also increased, but at a lower rate, while in Croatia it has declined, which shows the importance of tourism for the entire economy. The analysis of features of tourism employees showed that the age structure in analyzed activity has changed, which is, according to authors, the main contribution of the paper.
THE IMPACT OF ORGANIZATIONAL CULTURE ON KNOWLEDGE MANAGEMENT IN SMALL AND MEDIUM ENTERPRISES
Authors: Klepić Zdenko , Madžar Danijela
Published: November 2017

Purpose – The purpose of this work is to examine the relationship between organizational culture and knowledge management in small and medium enterprises. Organizational culture and knowledge management in today's unstable environment are becoming a major source of competitive advantage. Knowledge is an indisputable resource that allows the development of new products, creation of new ideas and strengthening the skills of people. Due to the rapid development of technology, globalization and the availability of resources, knowledge is crucial for the further development and survival of the organizations. Knowledge management is widely recognized as a competitive advantage and an increasing number of organizations are incorporating knowledge management as a core strategy to enhance their organizational competitive advantage. Methodology – The aim is to examine how and to what extend organizational culture affects on knowledge management. The research was conducted with survey on a sample of the small and medium enterprises. Findings – The results indicated that organizational culture had a positive correlation with knowledge m anagement. The establishment of a higher level organizational culture is a necessary precondition for successful implementation of knowledge management. Contribution – Results of this work can be of a significant value to organizations as they prepare to implement knowledge management initiatives. Organizations that are aware of their organizational culture can plan strategically and make informed decisions on the type of knowledge management. Knowing the degree of success that is associated with new business strategy can better apply scarce resources in more viable situations.
Socio-economic Factors Affecting Fertilization
Sustainability in Bangladesh: Effects of Traditional Way of Fertilization and Rental Land Farming
Authors: Rahman K. M. Atikur , Zhang Dunfu
Published: November 2017

Abstract: The study focuses on how socio-economic and demographic indicators affect fertilization sustainability (excessive amount of fertilization). Principally we aim to examine the significance magnitude of the effects of three socio-demographic variables such as traditional way of fertilization, rental land farming, and farmers’ younger age on over-fertilization in Bangladesh and other developing countries. In 1960s, Bangladesh state authority launched a campaign ‘Grow more Food’ to feed huge numbers of population and thus the farmers are provided chemical fertilizers and pesticides at a subsidized low price. Farmers began to use huge amount of fertilizers for gaining high yields and continued it to present causing environmental woes a lot. We interview (face-to-face, focus group discussion, and phone interview) 210 Bangladesh farmers in 2016 by semi-structured questionnaire. Data has been analyzed using General Linear Model (GLM) in Univariate Analysis of Variance. The study found the effect of traditional way of fertilization on excessive amount of fertilization is strongly significant at 1% level. Apart from, rental land farming and farmers’ younger age have a significant influence on over- fertilization; though their significance level (5% and 10% respectively) is quasi-strong. Policy makers can be able to formulate fertilizer policy on the basis of these findings.
Gastrointestinal Manifestations of Marfan Syndrome
Authors: Inayet Nashiz , Hayat Jamal , Poullis Andrew , Tome Maite , Child Ann
Published: November 2017

Symptoms attributed to the gastrointestinal manifestations of multi-system disorders play an important role in the long-term management of these conditions. Gastrointestinal complications of a variety of connective tissue disorders have been studied and there is an increased interest in the incidence and prevalence of these symptoms. Descriptions of the occurrence of gastrointestinal complications in Marfan syndrome have appeared infrequently in the medical literature. In this review article we focus on both structural and functional gastrointestinal pathology that may occur in patients with Marfan syndrome.
A Novel Mesoporous Multi-Template Molecularly Imprinted Polymer for Selective Separation and Determination of Panax notoginseng Saponins Simultaneously in Biological Samples
Authors: Sun Chenghong , Wang Jinhua , Huang Jiaojiao , Yao Dandan , Wang Chong-Zhi , Zhang Lei , Hou Shuying , Chen Lina , Yuan Chun-Su
Published: November 2017

The feasible, reliable and selective multi-template molecularly imprinted polymers (MT-MIPs) based on SBA-15 (SBA-15@MT-MIPs) for the selective separation and determination of the trace level of ginsenoside Rb1 (Rb1), ginsenoside Rg1 (Rg1) and notoginsenoside R1 (R1) (Panax notoginseng saponins, PNS) from biological samples were developed. The polymers were constructed by SBA-15 as support, Rb1, Rg1, R1 as multi-template, acrylamide (AM) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The new synthetic SBA-15@MT-MIPs were satisfactorily applied to solid-phase extraction (SPE) coupled with high performance liquid chromatography (HPLC) for the separation and determination of trace PNS in plasma samples. Under the optimized conditions, the limits of detection (LODs) and quantitation (LOQs) of the proposed method for Rb1, Rg1 and R1 were in the range of 0.63-0.75 ng mL-1 and 2.1-2.5 ng mL-1, respectively. The recoveries of R1, Rb1 and Rg1 were obtained between 93.4% and 104.3% with relative standard deviations (RSDs) in the range of 3.3-4.2%. All results show that the obtained SBA-15@MT-MIPs could be a promising prospect for the practical application in the selective separation and enrichment of trace PNS in the biological samples.
Economic Analysis of Flat-Plate and U-Tube Solar Collectors Using an Al2O3 Nanofluid
Authors: Kang Woobin , Shin Yunchan , Cho Honghyun
Published: November 2017

In this study, the efficiencies of flat-plate and U-tube solar collectors were investigated experimentally when an Al2O3 nanofluid was used as a working fluid and compared to those of solar collectors using water. The energy saving and CO2 and SO2 generated were calculated and compared to those of solar collectors using water. In addition, based on the experimental results, an economic analysis of the use of solar collectors in various countries was performed. As the concentration of the Al2O3 nanofluid increased, the performance of the solar collector improved. The highest efficiency for the solar collectors was shown at the concentration of 1.0 vol% with the nanoparticle size of 20 nm. The maximum efficiencies of the flat-plate and U-tube solar collectors using 1.0 vol%-Al2O3 nanofluid with 20-nm nanoparticles was 74.9% and 72.4%, respectively, when the heat loss parameter was zero. The efficiencies of the flat-plate and U-tube solar collectors using Al2O3 nanofluid were 14.8% and 10.7 higher, respectively, than those using water. When 50 EA flat-plate solar collectors were operated for one year using Al2O3 nanofluid, the coal use, generated CO2, and generated SO2 were 189.99 kg, 556.69 kg, and 2.03 kg less than those of solar collectors using water, respectively. In addition, the largest electricity cost reduction was in Germany.
Attitudes and Sensory Perceptions of Food Consumers towards Sustainable Technological Innovation in Mexico
Authors: Salgado-Beltrán Lizbeth , Beltrán-Morales Luis F. , Velarde-Mendivil Alma T. , Robles-Baldenegro Maria E.
Published: November 2017

Sustainable innovation in the agro-food system has become a strategy increasingly used by companies as a means to increase their competitiveness and position themselves in the market. In this context, the objective of this work is to identify the attitudes and sensory perceptions of consumers towards sustainable food technology through two scales (Food Technology Neophobia and Domain Specific Innovativeness) and hedonic tastings. For this, a new product was selected in the market: powder to prepare rice with milk. Most consumers have attitudes toward low neophobia to products with food technology, but there is also some caution, situation that is corroborated by the moderate predisposition towards innovations. Color and flavor attributes can make the difference in positive perceptions. It should not be forgotten that there is a segment of innovative sustainable consumers that represent a key market.
Subsidence Trends of Volturno River Coastal Plain (Northern Campania, southern Italy) Inferred by SAR Interferometry Data
Authors: Matano Fabio , Sacchi Marco , Vigliotti Marco , Ruberti Daniela
Published: November 2017

The Volturno Plain is one of the largest alluvial plain of peninsular Italy. This area is characterized by both natural and human induced subsidence, and is and most susceptible to coastal hazards. The present study is based on post-processing, analysis and mapping of the available Persistent Scatterer interferometry datasets, derived from combination of both ascending and descending orbits of three different SAR satellite systems, during an observation period of almost two decades (June 1992 - September 2010). The main output of the research work is a map of the vertical deformation that provides new insights into the areal variability of ground deformation processes (subsidence/uplift) of Volturno plain over the last decades. Vertical displacement values derived by interferometric data post-processing show that the Volturno river plain is characterized by significant subsidence in the central axial sectors and in the river mouth area, whereas moderate uplift is detected in the eastern part of the plain. Other sectors of the study area are characterized by moderate subsidence and/or stability. We infer that the subsidence recorded in  the Volturno plain is mainly a consequence of a natural process related to the compaction of the fluvial deposits that fill up the alluvial plain. Anthropic influence (e.g. water exploitation, urbanization) can be substantially regarded as an additional factor that only locally may enhance subsidence. The uplift imaged in the eastern sector of the plain can be related to tectonic activity. The study of subsidence in the Volturno plain is a valuable tool relevant for river flood analyses and coastal inundation hazard assessment addressed to risk mitigation.
Hydrochemical Characteristics and Multivariate Statistical Analysis of Natural Water System: A Case Study in Kangding County, Southwestern China
Authors: Zhang Yunhui , Xu Mo , Li Xiao , Qi Jihong , Zhang Qiang , Guo Jian , Yu Leilei , Zhao Rui
Published: November 2017

The utilization for water resource has been of great concern to human life. To assess the natural water system in Kangding County, the integrated methods of hydrochemcial analysis, multivariate statistics and geochemical modelling were conducted on surface water, groundwater and thermal water samples. Surface water and groundwater were dominated by Ca-HCO3 type, while thermal water belonged to Ca-HCO3 and Na-Cl type. The analyzing results concluded the driving factors that affect hydrochemical components. Following the results of the combined assessments, hydrochemcial process was controlled by the dissolution of carbonate and silicate minerals with slight influence from anthropogenic activity. The mixing model of groundwater and thermal water was calculated using silica-enthalpy method, yielding cold-water fraction of 0.56-0.79 and estimated reservoir temperature of 130-199 oC, respectively. δD and δ18O isotopes suggested surface water, groundwater and thermal springs were of meteoric origin. Thermal water should have deep circulation through the Xianshuihe fault zone, while groundwater flows through secondary fractures where it recharges with thermal water. Those analytical results were used to construct a hydrological conceptual model, providing a better understanding of the natural water system in Kangding County.
Noise Rejection in MMMs-Induced Fuzzy Co-Clustering
Authors: Honda Katsuhiro ,   Osaka Prefecture University 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan, Yamamoto Nami , Ubukata Seiki , Notsu Akira
Published: November 2017

Noise rejection is an important issue in practical application of FCM-type fuzzy clustering, and noise clustering achieves robust estimation of cluster prototypes with an additional noise cluster for dumping noise objects into it. Noise objects having larger distances from all clusters are designed to be assigned to the noise cluster, which is located in an equal (fixed) distance from all objects. Fuzzy co-clustering is an extended version of FCM-type clustering for handling cooccurrence information among objects and items, where the goal of analysis is to extract pair-wise clusters of familiar objects and items. This paper proposes a novel noise rejection model for fuzzy co-clustering induced by multinomial mixture models (MMMs), where a noise cluster is defined with homogeneous item memberships for drawing noise objects having dissimilar cooccurrence features from all general clusters. The noise rejection scheme can be also utilized in selecting the optimal cluster number through a sequential implementation with different cluster numbers.
Maths Support provision through embedded classes at LSBU
Authors: Mehbali Mohamed , Roberts Lesley
Published: November 2017

The present report summarises the communications presented at the sigma Network event on ‘Maths Support through Embedded Classes’ held at London South Bank University (LSBU). Two keynote speakers Professor Jon Warwick, from the LSBU Business School and Dr Lesley Roberts, Head of Skills for Learning, contributed valuable presentations. They outlined how maths support went through various stages and demonstrated the experience of embedded classes at LSBU. Five other delegates communicated their experiences of Maths Support through an embedded approach in their respective institutions.
Pembuatan Scout Learning Berbasis Multimedia Berupa Aplikasi Simulasi Penunjang Ekstrakurikuler Kepramukaan Kalangan Sekolah Dasar Di Jawa Barat
Authors: Sitanggang Andri Sahata
Published: November 2017

Kepramukaan merupakan salah satu organisasi yang merupakan media untuk membina para siswa dalam memperoleh potensi-potensi secara spritual, intelektual, mentalitas dan fisik agar para siswa memiliki kepribadian dan akhlak mulia, memiliki semangat kebangsaan yang tinggi, menciptakan pola pikir yang berwawasan luas, serta menjadikan siswa memilki peran yang tinggal dalam membantu masyarakat yang berjiwa patriotisme dan menjadi calon pemimpin bangsa dan negara. Adanya inovasi interaktif dengan dukungan teknologi informasi maka kepramukaan dapat ditingkatkan jumlah keterlibatan siswa untuk mengikuti ekstrakurikuler kepramukaan.
Berdasarkan hasil penelitian sebelumnya dimana rancangan sistem pembuatan scout learning yang diusulkan menggunakan metode pendekatan terstruktur sudah dibuat, maka penelitian ini berlanjut untuk menghasilkan suatu produk scout learning berbasis multimedia. Produk atau sistem yang dihasilkan mampu memberikan pengaruh yang besar bagi anak sekolah dasar dalam minat untuk mengikuti ekstrakuriler kepramukaan.
Produk yang dibuat menggunakan metode pengembangannya prototype dengan pengujian secara alfa dan betha sehingga menjadi sebuah aplikasi menjadi layak pakai sesuai kebutuhan. Pembuatan scout learning ini berorientasi secara visual yang dinamis, penggabungan animasi, video dan suara, gambar yang menarik, yang menyediakan simulasi sandi-sandi, perlengkapan pramuka serta video pengetahuan kepramukaan.
G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets
Authors: Estep Katrina N. , Butler Thomas J. , Ding Jun , Brosh Robert M.
Published: November 2017

Background:

Guanine-rich DNA can fold into highly stable four-stranded DNA structures called G-quadruplexes (G4). In recent years, the G-quadruplex field has blossomed as new evidence strongly suggests that such alternately folded DNA structures are likely to exist in vivo. G4 DNA presents obstacles for the replication machinery, and both eukaryotic DNA helicases and polymerases have evolved to resolve and copy G4 DNA in vivo. In addition, G4-forming sequences are prevalent in gene promoters, suggesting that G4-resolving helicases act to modulate transcription.

Methods:

We have searched the PubMed database to compile an up-to-date and comprehensive assessment of the field’s current knowledge to provide an overview of the molecular interactions of Gquadruplexes with DNA helicases and polymerases implicated in their resolution.

Results:

Novel computational tools and alternative strategies have emerged to detect G4-forming sequences and assess their biological consequences. Specialized DNA helicases and polymerases catalytically act upon G4-forming sequences to maintain normal replication and genomic stability as well as appropriate gene regulation and cellular homeostasis. G4 helicases also resolve telomeric repeats to maintain chromosomal DNA ends. Bypass of many G4-forming sequences is achieved by the action of translesion DNS polymerases or the PrimPol DNA polymerase. While the collective work has supported a role of G4 in nuclear DNA metabolism, an emerging field centers on G4 abundance in the mitochondrial genome.

Conclusion:

Discovery of small molecules that specifically bind and modulate DNA helicases and polymerases or interact with the G4 DNA structure itself may be useful for the development of anticancer regimes.
The Presence of Beneficial Organisms Associated to N and P Economy in the Rhizosphere of Native Vegetation in an Oligotrophic Savanna of Guárico State, Venezuela
Authors: Mora Edith , Toro Marcia , López-Hernández Danilo
Published: November 2017

Background:

In natural conditions, tropical plants are adapted to different ecological niches that can be associated to soil microorganisms which play a key role in nutrient cycling likeArbuscular mycorrhiza(AM), phosphate solubilizing bacteria (PSB) and/or nitrogen fixing rhizobia.

Methods:

We report a survey of the presence in a Trachypogon savanna located at Estación Experimental La Iguana (EELI) in Central Venezuela, of some beneficial plant-microorganism associations. In this savanna, plants present a high AM symbiosis affinity. The high mycorrhization and the presence of potential PSB suggest a synergic effect in plant P-uptake.

Results:

After screening the rhizospheres of 25 plant species from the zone, we could isolate a high proportion of potential PSB in relation to the total bacteria number from the rhizospheres ofCentrosema venosumandGalactia jussiaeana.

Conclusion:

Therefore, the presence of potential PSB in the rhizosphere of those species constitutes an important finding to discover novel biofertilizers for crop plants.
Scurvy: When it is a Forgotten Illness the Surgery Makes the Diagnosis
Authors: Bouaziz Wajdi , Rebai Mohamed Ali , Rekik Mohamed Ali , Krid Nabil , Ellouz Zoubaier , Keskes Hassib
Published: November 2017

Background:

Unlike most of animal species, human beings lack the enzymatic process for the conversion of glucose to ascorbic acid (vitaminC), and therefore getting the vitamin from food sources is essential. The association of the various signs caused by a deficiency of vitamin C is called scurvy or Barlow’s disease, an easily treatable disease but can be fatal. It is rare in the developed countries and even economically underdeveloped societies in which the basic diet is already rich in ascorbate.

Methods:

We describe here the case of a 4-year-old girl with cerebral palsy, in whom diagnosis concerns were oriented for osteomyelitis, based upon clinical presentation, ultrasonic and magnetic resonance imaging, led to a surgery revealing subperiosteal hematomas that argues in favor of scurvy.

Results:

After vitamin C therapy, the symptoms are gone and the general condition of the patient improved despite persistent radiological signs.

Conclusion:

Recent studies of sporadic cases report a high incidence of scurvy in children with autism or psychomotor retardation and the fact that musculoskeletal manifestations are more common. The mosaics of the symptoms of scurvy are varied and include dermatological, dental, bone and systemic manifestations, making it a forgotten and misdiagnosed illness. A heightened awareness is needed to avoid an unnecessary surgery, unnecessary tests and procedures and to be able to start treatment for a potentially fatal but easily curable disease.
Prospective Evaluation of Kidney Disease in Joubert Syndrome
Authors: Fleming Leah R. , Doherty Daniel A. , Parisi Melissa A. , Glass Ian A. , Bryant Joy , Fischer Roxanne , Turkbey Baris , Choyke Peter , Daryanani Kailash , Vemulapalli Meghana , Mullikin James C. , Malicdan May Christine , Vilboux Thierry , Sayer John A. , Gahl William A. , Gunay-Aygun Meral
Published: November 2017

Background and objectives

Joubert syndrome is a genetically heterogeneous ciliopathy associated with >30 genes. The characteristics of kidney disease and genotype-phenotype correlations have not been evaluated in a large cohort at a single center.

Design, setting, participants, & measurements

We evaluated 97 individuals with Joubert syndrome at the National Institutes of Health Clinical Center using abdominal ultrasonography, blood and urine chemistries, and DNA sequencing.

Results

Patients were ages 0.6–36 years old (mean of 9.0±7.6 years old); 41 were female. Mutations were identified in 19 genes in 92 patients; two thirds of the mutations resided in six genes: TMEM67, C5orf42, CC2D2A, CEP290, AHI1, and KIAA0586. Kidney disease was detected in 30%, most commonly in association with the following genes: CEP290 (six of six), TMEM67 (11 of 22), and AHI1 (three of six). No kidney disease was identified in patients with mutations in C5orf42 (zero of 15) or KIAA0586 (zero of six). Prenatal ultrasonography of kidneys was normal in 72% of patients with kidney disease. Specific types of kidney disease included nephronophthisis (31%), an overlap phenotype of autosomal recessive polycystic kidney disease/nephronophthisis (35%), unilateral multicystic dysplastic kidney (10%), and indeterminate-type cystic kidney disease (24%). Early-onset hypertension occurred in 24% of patients with kidney disease. Age at ESRD (n=13) ranged from 6 to 24 years old (mean of 11.3±4.8 years old).

Conclusions

Kidney disease occurs in up to one third of patients with Joubert syndrome, most commonly in those with mutations in CEP290, TMEM67, and AHI1. Patients with mutations in C5orf42 or KIAA0586 are less likely to develop kidney disease. Prenatal ultrasonography is a poor predictor of kidney involvement in Joubert syndrome. Unilateral multicystic dysplastic kidney and autosomal recessive polycystic kidney disease–like enlarged kidneys with early-onset hypertension can be part of the Joubert syndrome kidney phenotype.
Treatment patterns of biologics in US patients with ankylosing spondylitis: descriptive analyses from a claims database
Authors: Walsh Jessica A , Adejoro Oluwakayode , Chastek Benjamin , Park Yujin
Published: November 2017

Aim:
Examine treatment patterns among patients with active ankylosing spondylitis (AS) treated with a TNF inhibitor (TNFi).
Patients & methods:
Patients with AS who initiated a TNFi between 1 January 2013, and 31 January 2015, were identified in the Optum Research Database. Outcomes included adherence, persistence, discontinuation and therapy modifications of the index TNFi during 12-month follow-up.
Results:
Of the 426 patients included, 40.6% persisted on the index TNFi for ≥12 months, 31.0% discontinued, 21.4% switched to a different TNFi, and 7.0% discontinued and then restarted. Of the 333 patients who persisted on their TNFi for >90 days, 44.7% received ≥1 add-on medication.
Conclusion:
A high proportion of patients with AS switched, discontinued or modified their TNFi therapy.
ESTADO DE DESARROLLO PSICOMOTOR EN NIÑOS SANOS QUE ASISTEN A UN CENTRO INFANTIL EN SANTO DOMINGO, ECUADOR
Authors: Román  Sacón Jackeline , Calle Contreras Pamela
Published: November 2017

El objetivo de este artículo es describir los puntajes de desarrollo psicomotor en niños y niñas que acuden un centro infantil, mediante el formulario 028 que corresponde al Test de Denver II, estandarizado internacionalmente. Se trata de un estudio con un enfoque cuantitativo de carácter descriptivo-transversal. Se reclutaron 42 niños de 18-36 meses, que acuden al centro infantil en Santo Domingo de los Tsáchilas, Ecuador, para la aplicación del test de Denver II. Se excluyeron los niños con patologías graves con impedimento para contestar el instrumento por déficit en su capacidad física y mental. Mediante los puntajes obtenidos por la aplicación del test de Denver se observó que el déficit en el Área Personal-Social se da más en los niños (20%) que en las niñas (5%). En el Área Motriz Fino-Adaptativo el déficit se presenta tanto en los niños (10%) como en las niñas (9%). En el Área de Lenguaje se observó que existe un retardo muy marcado, se presentó más en los niños (35%) que en las niñas (18%). Al igual se observó que el déficit en el Área Motriz Grande se da más en los niños (15%) que en las niñas (5%). Destaca la alta frecuencia de déficit en el desarrollo psicomotor en la población evaluada, especialmente en los niños, donde el área más significativa fue la de Lenguaje. Se recomienda la estimulación temprana y los patrones de crianza para mejorar el desarrollo del lenguaje y el desempeño de los niños en las demás áreas.
Salud integral y migración: abordaje transcultural del Proceso Enfermero en un caso clínico del Programa de Salud Migratoria de Ginebra, Suiza
Authors: Marina Katia
Published: November 2017

La ola migratoria que se inició en Europa en 2015 alteró notablemente la relativa estabilidad política y social asentada desde hacía más de una década en el continente. El aumento inesperado de la cantidad de refugiados y solicitantes de asilo y su procedencia extra europea, sus diferencias culturales y lingüísticas y los motivos trágicos de su exilio, no podían sino plantear nuevos y urgentes retos en cuanto a su integración y atención socio sanitaria en los Estados de destino. Suiza recibió entre 2011 y 2016 más de 140.000 solicitudes de asilo y 2015 fue el año de mayor afluencia con casi 40.000 solicitudes, contra poco más de 27.000 en 2016. El 5,6% del total nacional fue asignado al Cantón de Ginebra, donde todo individuo relacionado con el trámite de asilo es asistido por programas de atención socio sanitaria públicos y específicos, que garantizan su accesibilidad a todos los servicios de salud. El objetivo es, a través del Modelo Transcultural de los Cuidados Enfermeros, poner de manifiesto aspectos relevantes de la atención sanitaria de solicitantes de asilo. Este trabajo se presenta como un estudio descriptivo de corte transversal y se basa en el Proceso Enfermero de un caso clínico, realizado en el Programa de Salud Migratoria de Ginebra, en enero de 2017.
Evaluación de tres métodos para la recuperación de metales pesados en fertilizantes
Authors: Pérez López Esteban , Barrantes Murillo César
Published: November 2017

Los abonos son fundamentales para la agricultura pero pueden producir contaminación con metales pesados que afectan la salud humana y de animales domésticos, por lo que es necesario tener métodos fiables para medir esos metales. Evaluamos la recuperación del método analítico empleado en un laboratorio de servicios en Costa Rica para la cuantificación de níquel, cromo, cadmio, plomo, arsénico, selenio y mercurio en fertilizantes. Estudiamos por separado una matriz fosfatada y otra nitrogenada, las cuales fueron enriquecidas a tres niveles de concentración determinadas dentro del rango de trabajo, para establecer la exactitud del procedimiento de análisis basándose en lo establecido por la AOAC para validación de métodos analíticos (80-110%). En el estudio cuantitativo tanto el cadmio como el cromo para las dos matrices presentaron resultados óptimos desde el punto de vista de recuperación; el plomo de igual forma tuvo una exactitud positiva excepto a niveles bajos de concentración; por otra parte el níquel en la matriz fosfatada se encontró ligeramente por encima del límite máximo admisible, no así la nitrogenada; y por último en los metales arsénico, selenio y mercurio no hubo recuperación para ambas muestras usando el procedimiento establecido.
Caracterización morfológica de dos genotipos de berenjena (Solanum melongena L.) cultivados en invernadero en Costa Rica
Authors: Arguedas García Cristina , Monge Pérez José Eladio
Published: November 2017

La berenjena es un cultivo con potencial de innovación en el mercado costarricense. Se realizó una caracterización morfológica de dos genotipos de berenjena (JMX-292 y JMX-1099) cultivados en invernadero en Alajuela, Costa Rica. Las variables cualitativas evaluadas fueron: hábito de crecimiento, ancho de la hoja, espinas en las hojas, color de la corola, largo del fruto, espinas del cáliz del fruto, color del fruto en madurez comercial, y cantidad de semillas. Las variables cuantitativas evaluadas fueron: ancho de hoja (cm), número de espinas por hoja, longitud del fruto (cm), número de espinas por cáliz, y número de semillas por fruto. Se presentaron diferencias significativas entre genotipos para el número de espinas por hoja (0,04 para JMX-1099 y 1,44 para JMX-292), longitud del fruto (15,50 y 13,12 cm, respectivamente), número de espinas por cáliz (0,20 y 3,48, respectivamente), y número de semillas por fruto (199,35 y 631,58, respectivamente). Ambos genotipos mostraron características innovadoras para el mercado, como la coloración blanca del fruto del JMX-292, y la poca cantidad de espinas en la hoja y en el cáliz y de semillas en el fruto del JMX-1099, por lo que estos genotipos pueden ser opciones interesantes para los productores.
Percepción sobre tutorías presenciales en asignaturas con componente virtual sobre Agroindustria en la UNED de Costa Rica
Authors: Andrés Jiménez Carmen , Bermúdez Mesén Ligia , Alfaro Rojas Dennis
Published: November 2017

Desde sus comienzos, la Universidad Estatal a Distancia de Costa Rica ha ofrecido tutorías presenciales como herramienta de apoyo a los estudiantes. Sin embargo, el uso de plataformas virtuales está aumentando en la Cátedra de Agroindustria y determinar si la tutoría presencial sigue siendo considerada necesaria por los estudiantes, así como las características deseadas y la opinión sobre las actividades de evaluación. Los estudiantes sugirieron que los cursos de pregrado necesitan más tutoría presencial que los cursos avanzados (p=0,003). Por otro lado, se prefieren las actividades evaluativas alternativas a las pruebas escritas en ambos niveles. Para las actividades evaluativas, todos los estudiantes preferirían el trabajo colaborativo sobre las pruebas.
Analisa Kerusakan Formasi Akibat Pekerjaan Perforasi Dengan Menggunakan Metoda Yildiz Pada Sumur Fr 168, Sumur 154, Dan Sumur 148 Di Lapangan X
Authors: Musnal Ali
Published: November 2017

Komplesi perforasi merupakan salah satu alternatif penyelesaian sumur untuk formasi yang tidak kompak. Perforasi dilakukan pada lapisan produktif dengan cara membuat lubang pada casing sebagai penghubung   antara lapisan produktif dengan lubang sumur, sehingga terjadi aliran fluida dari formasi kelubang sumur. Pada umumnya ketika kegiatan perforasi dilakukan akan terjadi kerusakan sumur yang ditandai dengan adanya skin. Untuk menentukan besarnya harga skin yang di akibatkan oleh perforasi tersebut pada penelitian ini diterapkan metoda Yildiz. Perhitungan skin diperoleh berturut turut pada sumur FR 168,154 dan 148 adalah 6.835,6.784 dan7.610. Berdasarkan skin tersebut diperoleh   produktivitas indeks (PI)berturut turut adalah 0.10 bpd/psi, 1.86 bpd/psi dan 0,24 bpd/psi serta harga laju produksi (Q) berturut-turut adalah 168.297 bfpd, 1151.533 bfpd dan 371.271 bfpd. Dari perbandingan kedua parameter hasil perhitungan  Q dan PI menggunakan metoda Yildiz  menghasilkan harga yang lebih besar dibandingkan harga dari aktualnya.
Studi Kebijakan Migas di Indonesia
Authors: Ariyon Muhammad
Published: November 2017

Studi kebijakan minyak dan gas bumi di Indonesia dilakukan untuk mengidentifikasi dan membahas aspek-aspek dalam kebijakan migas di Indonesia mulai dari zaman Hindia Belanda, era orde lama, era orde baru dan era reformasi. Aspek-aspek penting yang dikaji yaitu: Hak Kepemilikan Migas, Hak Pengelolaan, Kebijakan Fiskal, Kebijakan Ekspor dan Impor, Kebijakan Administrasi, Kebijakan Pengembangan Wilayah dan Masyarakat dan Kebijakan Lingkungan. Studi ini juga mengkaji sejauh mana penerapan aspek-aspek regulasi di bidang minyak dan gas bumi pada berbagai produk hukum perminyakan yang pernah berlaku, yaitu: Indische Mijnwet 1899, UU No. 44 Tahun 1960 tentang Pertambangan Minyak dan Gas Bumi, UU No. 8 Tahun 1971 tentang Perusahaan Pertambangan Minyak dan Gas Bumi Negara (Pertamina) dan UU No. 22 Tahun 2001 tentang Minyak dan Gas Bumi. Pemahaman mengenai aspek hukum dalam industri minyak dan gas nasional sangat penting mengingat kedudukan Indonesia sebagai salah satu negara produsen dan importir migas. Diharapkan hasil studi ini dapat menjadi sumbangan pemikiran bagi perumusan Kebijakan Pengelolaan Migas di Indonesia.
Karakterisasi Heterogenitas Reservoir Lapangan X Dengan Dynamic Lorenz Coefficient
Authors: Herawati Ira
Published: November 2017

Pada proses injeksi air (secondary recovery) dimana air berfungsi mendorong minyak ke sumur produksi, distribusi air akan dipengaruhi oleh sifat heterogenitas suatu reservoir. Distribusi pendesakan air sulit untuk dideteksi karena air cenderung untuk mengalir di zona-zona yang berpermeabilitas tinggi. Oleh karena itu dalam rangka pengukuran heterogenitas reservoir pada tahap injeksi air, penting untuk mempertimbangkan pengaruh geometri aliran yang disebabkan oleh sifat dinamika batuan. Studi ini bertujuan untuk melakukan karakterisasi heterogenitas reservoir dengan injeksi air di Lapangan X. Proses pengukuran derajat heterogenitas menggunakan metode Lorenz coefficient dinamis (dynamic Lorenz coefficient) yang merupakan pengembangan dari parameter Lorenz coefficient. Sifat dinamis injeksi air yang meliputi geometri aliran injeksi dianalisis dengan menggunakan streamline. Informasi yang didapat dari simulasi streamline berupa laju alir injeksi dan time of flight (TOF) streamline akan menjadi dasar perhitungan volume pori yang tersapu oleh air injeksi. Sehingga nilai flow capacity dan storage capacity (F – F) untuk masing-masing region dapat dihitung. Selanjutnya derajat heterogenitas reservoir dihitung dengan persamaan Lorenz.
Pengaruh Lumpur Pemboran Dengan Emulsi Minyak Terhadap Kerusakan Formasi Batu Pasir Lempungan (Analisa Uji Laboratporium)
Authors: Fitrianti Fitrianti
Published: November 2017

Porositas dan permeabilitas merupakan bagian dari sifat fisik batuan yang memiliki keterkaitan. Porositas merupakan perbandingan dari volume bulk batuan terhadap total volume batuan sementara permeabilitas merupakan ukuran media berpori untuk meloloskan fluida agar fluida dapat mengalir. Untuk menentukan harga porositas dan permeabilitas tersebut dapat dilakukan pada uji laboratorium. Dengan adanya perbandingan harga permeabilitas dari sample batuan, dapat diketahui seberapa besar nilai skin dari batuan reservoir tersebut. Tujuan dari penelitian ini yaitu untuk mengetahui seberapa besar pengaruh lumpur pemboran dengan emulsi minyak terhadap kerusakan formasi batu pasir lempungan. Adapun data yang menjadi acuan utama untuk penelitian ini adalah data permeabilitas dari sample core yang didapat dengan menggunakan alat Gas Permeameter. Dalam penelitian ini , Sample core yang digunakan yaitu sample core batu pasir lempungan sebanyak 10 buah dengan harga porositras yang seragam sesuai dengan pengukuran helium porosimeter dan akan  dikontaminasi terhadap lumpur pemboran emulsi minyak. Pembuatan lumpur emulsi minyak disesuaikan dengan standar API SPEC. Sifat fisik lumpur yang perlu diukur dalam penelitian ini yaitu : Densitas lumpur, Rheologi lumpur, pH lumpur, Filtare lumpur dan ketebalan Mud Cake. Setelah dilakukan pengukuran dan uji laboratorium didapat harga permeabilitas sample core rata – rata sebelum dijenuhi dengan lumpur pemboran sebesar 1.2 Darcy dan permeabilitas rata – rata sample core setelah dijenuhi dengan lumpur pemboran sebesar 0.13 Darcy. Dari hasil perbandingan permeabilitas awal dan permeabilitas akhir sample core didapat nilai kerusakan sample core setelah dikontaminasi dengan lumpur emulsi minyak sebesar 8.2. Dari hasil penelitian yang telah dilakukan maka dapat disimpulkan bahwa kerusakan sample core batu pasir lempungan setelah dikontaminasi dengan lumpur emulsi minyak cukup besar jika dibandingakan dengan kontaminasi pada sample core batu pasir, yang ditunjukkan oleh kecilnya harga skin dari sample core tersebut.
Evaluasi Kinerja Injeksi Air Menggunakan Analisa Fall-Off Test Dan Analisa Kualitas Air Menggunakan Metode Stiff-Davis Di Lapangan Selta
Authors: Veri Irfan Nofta
Published: November 2017

Porositas dan permeabilitas merupakan bagian dari sifat fisik batuan yang memiliki keterkaitan. Porositas merupakan perbandingan dari volume bulk batuan terhadap total volume batuan sementara permeabilitas merupakan ukuran media berpori untuk meloloskan fluida agar fluida dapat mengalir. Untuk menentukan harga porositas dan permeabilitas tersebut dapat dilakukan pada uji laboratorium. Dengan adanya perbandingan harga permeabilitas dari sample batuan, dapat diketahui seberapa besar nilai skin dari batuan reservoir tersebut. Tujuan dari penelitian ini yaitu untuk mengetahui seberapa besar pengaruh lumpur pemboran dengan emulsi minyak terhadap kerusakan formasi batu pasir lempungan. Adapun data yang menjadi acuan utama untuk penelitian ini adalah data permeabilitas dari sample core yang didapat dengan menggunakan alat Gas Permeameter. Dalam penelitian ini , Sample core yang digunakan yaitu sample core batu pasir lempungan sebanyak 10 buah dengan harga porositras yang seragam sesuai dengan pengukuran helium porosimeter dan akan  dikontaminasi terhadap lumpur pemboran emulsi minyak. Pembuatan lumpur emulsi minyak disesuaikan dengan standar API SPEC. Sifat fisik lumpur yang perlu diukur dalam penelitian ini yaitu : Densitas lumpur, Rheologi lumpur, pH lumpur, Filtare lumpur dan ketebalan Mud Cake. Setelah dilakukan pengukuran dan uji laboratorium didapat harga permeabilitas sample core rata – rata sebelum dijenuhi dengan lumpur pemboran sebesar 1.2 Darcy dan permeabilitas rata – rata sample core setelah dijenuhi dengan lumpur pemboran sebesar 0.13 Darcy. Dari hasil perbandingan permeabilitas awal dan permeabilitas akhir sample core didapat nilai kerusakan sample core setelah dikontaminasi dengan lumpur emulsi minyak sebesar 8.2. Dari hasil penelitian yang telah dilakukan maka dapat disimpulkan bahwa kerusakan sample core batu pasir lempungan setelah dikontaminasi dengan lumpur emulsi minyak cukup besar jika dibandingakan dengan kontaminasi pada sample core batu pasir, yang ditunjukkan oleh kecilnya harga skin dari sample core tersebut.
Mengatasi Kerusakan Formasi Dengan Metoda Pengasaman Yang Kompetibel Pada Sumur Minyak Dilapangan X
Authors: Musnal Ali
Published: November 2017

Laju produksi suatu sumur minyak akan mengalami penurunan di akibatkan antara lain menurunnya tekanan reservoir (Pr), dan juga karena terjadi kerusakan formasi produktif.

  Adapun type-type penyebab kerusakan formasi itu adalah :

Scale : Suatu endapan yang terbentuk akibat kristalisasi dari ion-ion mineral yang larut dalam air dan disebabkan oleh adanya senyawa pembentuk kerak didalam air yang melebihi kelarutannya pada keadaan kesetimbangan.

Clay : Disebabklan karena fress water atau filtrat Lumpur pemboran yang merembes keformasi yang mengandung shale.

Partikel Plugging : Partikel lumpur pemboran atau bubur semen dapat menyebabkan tertutupnya pori pori batuan.

Untuk melarutkan atau menghilangkan penyebab kerusakan formasi tersebut diatas, dilakukan pengasaman. Sebelum dilakukan pengasaman  harus melakukan analisa pemilihan jenis asam yang compatible dengan teknik dan pelaksanaan yang baik dilapangan. Ada 3 jenis pengasaman yang lazim digunakan yaitu : Matrik acidizing, Acid Washing dan Acid Fracturing.Methoda yang dilakukan dalam penelitian ini dengan mengambil data dilapangan  seperti, Data Produksi, Water Analysis, Mineralogi, Menghitung Volume Asam,kemudian menghitung parameter skin,laju produksi, produktivitas Indek dan Flow Effisiensi baik sesudah maupun sebelum pengasaman dilakukan. Dari data lapangan ini didapat mineral quartz (grain) sebanyak 71,2%, illite dan dolomite 4,6 %, calcite2,3 %, kaolinite 1,8 %, smeltite 0,1 % dan kandungan kalsium carbonat 22,2 %,maka dipilih jenis asam yang compatible digunakan yaitu Mud Acid (HCL + HF), untuk lebih jelas dapat dilihat uraian yang dipaparkan dalam penelitian ini.
Perencanaan Pengangkatan Buatan dengan Sistim Pemompaan Berdasarkan Data Karakteristik Reservoir
Authors: Fitrianti Fitrianti
Published: November 2017

Pemilihan metode artificial lift terutama dengan menggunakan sitem pemompaan yang sesuai dapat memberikan hasil optimum adalah sangat penting untuk dilakukan, karena menyangkut keekonomian dari sumur produksi suatu lapangan. Selain itu juga diperlukan evaluasi dan perencanaan ulang karena perubahan kondisi reservoir selama masa produksi.
Perhitungan Laju Aliran Fluida Kritis Untuk Mempertahankan Tekanan Reservoir Pada Sumur Ratu Di Lapangan Kinantan
Authors: Musnal Ali
Published: November 2017

Sumur yang telah diproduksikan fluida reservoirnya, sehubungan dengan perjalanan waktu lamanya produksi sumur tersebut, sudah dipastikan laju produksinya akan berkurang, hal ini disebabkan salah satu parameternya adalah turunnya tekanan reservoir. Tekanan reservoir mempunyai peranan aktif untuk mendorong fluida dari reservoir kepermukaan. Banyak cara yang telah dilakukan untuk mempertahankan Tekanan reservoir antara lain dengan menginjeksikan air kelapangan minyak tersebut melalui sumur injeksi, hal ini terkenal dengan istilah water Flooding. Dan pada penelitian ini untuk mempertahankan tekanan reservoir suatu sumur adalah dengan melakukan produksi sumur tersebut dibawah laju aliran kritis. Untuk mendapatkan laju alir kritis dan menetukan panjang interval perforasi suatu sumur  dapat dihitung dengan menggunakan beberapa metode. Antara lain yaitu metode Chaperon, Chierici, Meyer, Gardner and Pirson. Sebagai aplikasi dari penelitian ini diambil data sumur Ratu dilapangan Kinantan yang merupakan salah satu lapangan minyak di daerah Riau.