bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine learning models development for accurate multi-months ahead drought forecasting: Case study of the Great Lakes, North America
Authors: Hameed Mohammed Majeed , Razali Siti Fatin Mohd , Mohtar Wan Hanna Melini Wan , Rahman Norinah Abd , Yaseen Zaher Mundher
Published: October 2023

The Great Lakes are critical freshwater sources, supporting millions of people, agriculture, and ecosystems. However, climate change has worsened droughts, leading to significant economic and social consequences. Accurate multi-month drought forecasting is, therefore, essential for effective water management and mitigating these impacts. This study introduces the Multivariate Standardized Lake Water Level Index (MSWI), a modified drought index that utilizes water level data collected from 1920 to 2020. Four hybrid models are developed: Support Vector Regression with Beluga whale optimization (SVR-BWO), Random Forest with Beluga whale optimization (RF-BWO), Extreme Learning Machine with Beluga whale optimization (ELM-BWO), and Regularized ELM with Beluga whale optimization (RELM-BWO). The models forecast droughts up to six months ahead for Lake Superior and Lake Michigan-Huron. The best-performing model is then selected to forecast droughts for the remaining three lakes, which have not experienced severe droughts in the past 50 years. The results show that incorporating the BWO improves the accuracy of all classical models, particularly in forecasting drought turning and critical points. Among the hybrid models, the RELM-BWO model achieves the highest level of accuracy, surpassing both classical and hybrid models by a significant margin (7.21 to 76.74%). Furthermore, Monte-Carlo simulation is employed to analyze uncertainties and ensure the reliability of the forecasts. Accordingly, the RELM-BWO model reliably forecasts droughts for all lakes, with a lead time ranging from 2 to 6 months. The study’s findings offer valuable insights for policymakers, water managers, and other stakeholders to better prepare drought mitigation strategies.
Fear of falling: Scoping review and topic analysis using natural language processing
Authors: Kolpashnikova Kamila , Harris Laurence R. , Desai Shital
Published: October 2023

Fear of falling (FoF) is a major concern among older adults and is associated with negative outcomes, such as decreased quality of life and increased risk of falls. Despite several systematic reviews conducted on various specific domains of FoF and its related interventions, the research area has only been minimally covered by scoping reviews, and a comprehensive scoping review mapping the range and scope of the research area is still lacking. This review aims to provide such a comprehensive investigation of the existing literature and identify main topics, gaps in the literature, and potential opportunities for bridging different strains of research. Using the PRISMA-ScR guidelines, we searched the Cochrane Database of Systematic Reviews, CINAHL, Embase, MEDLINE, PsycInfo, Scopus, and Web of Science databases. Following the screening process, 969 titles and abstracts were chosen for the review. Pre-processing steps included stop word removal, stemming, and term frequency-inverse document frequency vectorization. Using the Non-negative Matrix Factorization algorithm, we identified seven main topics and created a conceptual mapping of FoF research. The analysis also revealed that most studies focused on physical health-related factors, particularly balance and gait, with less attention paid to cognitive, psychological, social, and environmental factors. Moreover, more research could be done on demographic factors beyond gender and age with an interdisciplinary collaboration with social sciences. The review highlights the need for more nuanced and comprehensive understanding of FoF and calls for more research on less studied areas.
The Aspergillus fumigatus UPR is variably activated across nutrient and host environments and is critical for the establishment of corneal infection
Authors: Kamath Manali M. , Lightfoot Jorge D. , Adams Emily M. , Kiser Ryan M. , Wells Becca L. , Fuller Kevin K.
Published: October 2023

The Aspergillus fumigatus unfolded protein response (UPR) is a two-component relay consisting of the ER-bound IreA protein, which splices and activates the mRNA of the transcription factor HacA. Spliced hacA accumulates under conditions of acute ER stress in vitro, and UPR null mutants are hypovirulent in a murine model of invasive pulmonary infection. In this report, we demonstrate that a hacA deletion mutant (ΔhacA) is furthermore avirulent in a model of fungal keratitis, a corneal infection, and an important cause of ocular morbidity and unilateral blindness worldwide. Interestingly, we demonstrate that A. fumigatus hacA is spliced in infected lung samples, but not in the cornea, suggesting the amount of ER stress experienced by the fungus varies upon the host niche. To better understand how the UPR contributes to fungal cell biology across a spectrum of ER-stress levels, we employed transcriptomics on the wild-type and ΔhacA strains in glucose minimal media (low stress), glucose minimal media with dithiothreitol (high stress), and gelatin minimal media as a proxy for the nutrient stress encountered in the cornea (mid-level stress). These data altogether reveal a unique HacA-dependent transcriptome under each condition, suggesting that HacA activity is finely-tuned and required for proper fungal adaptation in each environment. Taken together, our results indicate that the fungal UPR could serve as an important antifungal target in the setting of both invasive pulmonary and corneal infections.
Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans
Authors: Nasrallah Mohamad A. , Peterson Nicholas D. , Szumel Elizabeth S. , Liu Pengpeng , Page Amanda L. , Tse Samantha Y. , Wani Khursheed A. , Tocheny Claire E. , Pukkila-Worley Read
Published: October 2023

Sphingolipids are required for diverse biological functions and are degraded by specific catabolic enzymes. However, the mechanisms that regulate sphingolipid catabolism are not known. Here we characterize a transcriptional axis that regulates sphingolipid breakdown to control resistance against bacterial infection. From an RNAi screen for transcriptional regulators of pathogen resistance in the nematode C. elegans, we identified the nuclear hormone receptor nhr-66, a ligand-gated transcription factor homologous to human hepatocyte nuclear factor 4. Tandem chromatin immunoprecipitation-sequencing and RNA sequencing experiments revealed that NHR-66 is a transcriptional repressor, which directly targets sphingolipid catabolism genes. Transcriptional de-repression of two sphingolipid catabolic enzymes in nhr-66 loss-of-function mutants drives the breakdown of sphingolipids, which enhances host susceptibility to infection with the bacterial pathogen Pseudomonas aeruginosa. These data define transcriptional control of sphingolipid catabolism in the regulation of cellular sphingolipids, a process that is necessary for pathogen resistance.
Adaptive Absorbing Boundary Layer for the Nonlinear Schrödinger Equation
Authors: Stimming Hans Peter , Wen Xin , Mauser Norbert J.
Published: October 2023

We present an adaptive absorbing boundary layer
technique for the nonlinear Schrödinger equation that is
used in combination with the Time-splitting Fourier spectral
method (TSSP) as the discretization for the NLS equations.
We propose a new complex absorbing potential (CAP) function based on high
order polynomials,
with the major improvement that an explicit
formula for the coefficients in the potential function
is employed for adaptive parameter selection.
This formula is obtained by an extension of the analysis in [R. Kosloff and D. Kosloff,
Absorbing boundaries for wave propagation problems,
J. Comput. Phys. 63 1986, 2, 363–376].
We also show that our imaginary potential function
is more efficient than what is used in the literature.
Numerical examples show that our ansatz is significantly better than existing approaches.
We show that our approach can very accurately compute the solutions of
the NLS equations in one dimension,
including in the case of multi-dominant wave number solutions.
Is Biblical Studies Stuck in Antiquarianism? The Case of Behemoth and Leviathan
Authors: Sneed Mark
Published: October 2023

In this article, a trajectory is traced that demonstrates that the soft consensus that Behemoth and Leviathan are the hippo and croc, respectively, is part of a larger phenomenon whereby these originally monstrous beasts have become domesticated and demythologized or their mythological nature rationalized. The great beasts as natural Egyptian animals only goes back to a 17th century Huguenot who was an etymologist, orientalist, antiquarian, and minister. This process of/domestication/demythologization in a weak form actually can be discerned in the Hebrew Bible itself but reaches its zenith during the Enlightenment. In the article, a trajectory of protest against this process is mapped out. And, finally, monsters are shown to be important theodicean agents in the ancient world as well as representing important mechanisms of cultural identity.
Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
Authors: Huo Rongxiu , Huang Xinxiang , Lin Jinying
Published: October 2023

The study aimed to analyze the mortality and leading causes of death associated with Sjögren’s syndrome (SS) in the United States (US) between 1999 and 2020 using a multicause approach. We analyzed mortality based on SS as the cause-of-death. Using mortality rates, number of deaths, and historical trends, we examined sex, age of death, comparisons of SS- and polymyalgia rheumatica-related deaths (multiple cause-of-death) in the last 20 years, changes in the ranking of causes of death when SS was the underlying cause-of-death (UCD) in the first and last 5 years of the last 20 years, and the number of deaths and standardized mortality (per 100,000 people) when SS combined with interstitial lung disease (ILD) or tumor was the multiple cause-of-death. An SS-standardized mortality trend chart and a trend line were created. In 22 years, the total number of SS-related deaths in the US was 7,817, including 7,016 women. When SS was the UCD and non-UCD, the standardized ratios of female-to-male deaths (per 100,000 people) were approximately 4.6–13:1 and 6.8–19.6:1, respectively. SS-related deaths were more common in people aged >60 years and concentrated in patients aged 60–79. In cases where SS and polymyalgia rheumatica were the multiple cause-of-death, the number of deaths and age-standardized mortality of SS and polymyalgia rheumatica increased, although lower in SS than in polymyalgia rheumatica. Regarding SS as the UCD, heart disease ranks first. Concerning the number of deaths and standardized mortality in the first (1999–2003) and second (2016–2020) 5 years, when SS-ILD and SS combined with tumors were the multiple causes of death, the number increased in the second 5 years compared to that in the first 5 years. When SS combined with COVID-19 was the multiple cause-of-death, 73 deaths occurred, comprising 64 females and 9 males. Death predominance was observed among women and patients aged 60–79 years with SS. Although the SS-standardized mortality rate was low, an increasing trend was observed. When SS was the primary cause-of-death, heart disease remained primarily involved, followed by malignant neoplasms. The number of patients with SS-ILD and SS combined with tumors in the past 22 years and the standardized mortality rate after 5 years increased compared with those of the previous 5 years. Concurrent SS and COVID-19 may be related to the increased SS deaths.
Crystal structure of O-(3-(benzo[d]thiazol-2-yl)naphthalen-2-yl) O-phenyl carbonothioate, C24H15NO2S2
Authors: Wang Qian , Liu Yong-Lang , Ye Jiang-Hai , Zou Juan , Wu Chong , Yang Wu-De
Published: October 2023

C24H15NO2S2, monoclinic, P21/c (no. 14), a = 20.8250(11) Å, b = 5.3649(3) Å, c = 18.8787(11) Å, β = 106.278(2)°, V = 2024.7(2) Å3, Z = 4, Rgt
(F) = 0.0439, wRref
(F
2) = 0.1015, T = 273 K.
Crystal structure of the hydrogen storage active phase La12Mg46LiMn
Authors: Pavlyuk Nazar , Nytka Vitalii , Kordan Vasyl , Pavlyuk Volodymyr
Published: October 2023

La12Mg46LiMn, cubic,

F
m

3
‾

m

$Fm\overline{3}m$

(no 225), a = 14.7119(3) Å, V = 3184.24(19) Å3, Z = 2, R

gt
(F) = 0.0330, wR

ref
(F
2) = 0.0601, T = 293(2) K.
Crystal structure of (2-(2-pyridine)-benzimidazole-κ
2 N,N′)-bis(1-phenylpyrazole-κ
2 C,N)iridium(III) hexafluorophosphate, C30H22F6IrN7P
Authors: Qian Jun , Chen Chunjie , Ma Liang , Wang Yida
Published: October 2023

C30H22F6IrN7P, monoclinic, P21/c (no. 4), a = 8.8876(3) Å, b = 32.8428(9) Å, c = 10.5010(3) Å, β = 106.623(2)∘, V = 2937.07(16) Å3, Z = 4, R
gt(F) = 0.0572, wR
ref(F
2) = 0.1171, T = 293 K.
Effect of particle size distribution on microstructure and chloride permeability of blended cement with supplementary cementitious materials
Authors: Gao Ge , Li Qiang , Luo Hongjie , Huang Xiao
Published: October 2023

In order to improve the chloride ion penetration resistance of supplementary cementitious materials (SCMs) in blended cement, this study optimizes the particle size distribution of cementitious components based on the Fuller model. Portland cement (PC), fly ash (FA), and ground granulated blast furnace slag (GGBFS) are successfully divided into four particle size ranges by precision air classifier, which are 0–8, 8–30, 30–50, and 50–80 μm, respectively. The optimum cementitious materials in four ranges based on 28-day compressive strength are determined by nine groups of orthogonal tests. The blended cement with optimal performance is obtained by GGBFS in 0–8 μm, PC in 8–30 μm, GGBFS in 30–50 μm, and FA in 50–80 μm. The results show that the blended cement with SCMs based on Fuller model have superior microstructure and chloride ion penetration resistance, which is due to their smaller pore size, a strong volcanic ash effect, and chloride ion binding ability. In addition, this research presents a novel approach for realizing the application of a large amount of SCMs in blended cement.
Grain Size Evaluation of Selectively Heated Sintered PM Preforms under Cold Compression
Authors: Ramakrishnan Tharmaraj , Maharajan Joseph Davidson
Published: October 2023

The mechanical qualities of the materials determine the final product’s performance in engineering applications, and the analysis of material grain size could change these attributes. Controlling grain size is critical in the metal forming process for obtaining good mechanical characteristics, which improves the final component’s performance. The purpose of this research is to determine the impact of selective heating (SH) on the microstructure of sintered powder metallurgy aluminum- and titanium-based preforms for various titanium weight fractions (2–6 %) and starting relative densities (80–90 %). Cold upsetting tests of sintered aluminum-titanium workpieces were carried out in a hydraulic press for several ranges of SH (100°C–250°C). The microstructure of aluminum-titanium specimens was examined using an optical microscope, and the intercept line approach was employed to calculate the average grain size (AGS). Because of dynamic recrystallization and grain development, the AGS of aluminum-titanium preforms is found to increase as the SH temperature rises.
On the Intraoperative Awareness General Anesthesia
Authors: Burokiene Virginija Y.
Published: October 2023

General anesthesia is a crucial component of modern medical practice, enabling surgeons to perform complex procedures and ensuring patient comfort. However, within the realm of general anesthesia, a rare but significant phenomenon called intraoperative awareness has garnered attention. Intraoperative awareness refers to the state of partial or complete consciousness experienced by some patients during surgery, despite being under anesthesia. This article aims to explore the concept of general anesthesia and intraoperative awareness, shedding light on its prevalence, causes, impact, and management strategies. Understanding this phenomenon is vital for healthcare professionals to improve patient outcomes and enhance the safety of surgical procedures.
Family Functioning, Peers Support, and Future Orientation in Marriage in Teenagers
Authors: Silalahi Elinter Natalina , Riasnugrahani Missiliana , Setiawan Tery
Published: October 2023

Adolescents' future orientation toward marriage refers to the subjective ideas they form about the marriage they want in the future, including how they think, explore, and plan their lifetime development journey concerning marriage. Teenagers who lack future orientation in marriage frequently engage in promiscuity, unhealthy romantic relationships, and early marriages, which often result in divorce. For their future marriage to be successful, adolescents must develop a future-oriented marriage. This study examines how family function and peers support can predict the development of future orientation in marriage in class XII students of private schools in Tangerang City. This research explains the essential components needed in preparing for future orientation marriage, including romantic relationships. Through the convenience sampling technique, 212 students took part in the study. This study used three questionnaires with good validity and reliability: The McMaster Family Assessment Device (MMFAD), Peers Support, and The Prospective Life Course (PLC) Questionnaire – Future Marriage and Family. With hierarchical regression analysis techniques, this study shows that family functioning, peers support, and gender are correlated with future orientation-marriage. Students who believe that their families have healthy and effective structures, organizations, and patterns of interaction between family members are better able to develop a more focused and clearer subjective picture of the future in the field of marriage. This study also shows that students who receive high peers support are more successful in developing a clear and focused future orientation marriage. Based on this research, we suggest examining the future orientation-marriage to a wider target population using a random sampling technique so the result will have a broader generalization.
Quality management for design – Bid-build versus design-and-build contracts for infrastructure projects
Authors: Gashi Esat , Ivezaj Marjan
Published: October 2023

Selecting the construction delivery method during the contracting period is one of the most important decisions determining the quality of large-scale infrastructure projects. Infrastructure projects have the most complex production processes in civil engineering. Infrastructure projects are among the most complex and resource-intensive endeavours in civil engineering due to their size, scope, multidisciplinary nature, regulatory requirements, financing challenges, environmental considerations, and the need for long-term planning and maintenance. Effective project management, collaboration, and a deep understanding of these challenges are crucial for the successful execution of infrastructure projects. Implementing such projects inevitably demands proper quality management throughout the project lifecycle. Two primary types of construction contracts are under implementation worldwide: Design-Bid-Build (DBB) and Design–and–Build (DB) contracts. In the Western Balkans region, both types of contracts are utilized for infrastructure projects, A noticeable trend is emerging toward transitioning from DBB to DB contracts. This paper provides a comprehensive analysis of quality management within the context of construction contracts with a focus on the roles and responsibilities of key stakeholders and how these factors affect the achievement of quality objectives while managing constraints related to cost and time. This research aims to improve construction practices by selecting an adequate type of contract for construction practices and ensuring successful project outcomes.
MICROBIOMES OF HUMAN, LIVESTOCK ANIMAL GASTROINTESTINAL TRACTS AND OF FOOD PRODUCTS AND COMPOUND FEEDS: CONNECTIONS AND IMPACTS. PART 1
Authors: Yegorov B. , Yegorova А. , Yeryganov K.
Published: October 2023

The physiological mechanisms of food digestion in humans and feed digestion in animals are determined by the structure of the gastrointestinal tract (GIT) and diet. Accordingly, humans are omnivores, while domestic animals are divided into ruminants, monogastric herbivores, and monogastric omnivores, and birds are divided into herbivores (geese, ducks) and omnivores (chickens, turkeys, etc.). The digestion and assimilation of food and feed depends not only on own mechanisms but also on the GIT microbiome. The location of the most important part of this microbiome and its composition depend on the species: in ruminants, it is the rumen microbiome, in horses – the cecum (it is a counterpart of the rumen), in humans and pigs – the intestine, in birds – the crop, gizzard and cecum. These microbiomes are in constant close connection with the host organism, and this connection is realized through numerous molecular mechanisms of interaction between bacterial cells and host cells and tissues. GIT microorganisms not only help to assimilate food (feed) by partially digesting it, but also secrete biologically active substances that have protective, stimulating and other beneficial effects for the host. In adult hosts, this GIT microbiota is well developed and stable, while in children and young animals it can be much more mobile and vulnerable. Food and feed contain many components that are a favorable medium for the development of microorganisms. Raw materials and components of animal origin are the most contaminated, while vegetable raw materials and components, as well as premixes, contain significantly fewer microorganisms. Among the microorganisms colonizing raw materials, food and feeds, coliforms, salmonellae and molds may be present. In young animals, the feed microbiota ingested into the GIT, even without taking into account obligate or opportunistic pathogens, can cause shifts or changes in the digestive microenvironment towards deterioration, which will have a corresponding impact on the efficiency of feed absorption and, through it, on the efficiency of feeding and animal productivity.
SCIENTIFIC SUBSTANTIATION OF CREAM HEATING DURATION IN THE TECHNOLOGY OF SOUR CREAM, ENRICHED WITH PROTEIN
Authors: Polishchuk G. , Sharakhmatova T. , Shevchenko I. , Manduk O. , Mykhalevych A. , Pukhlyak A.
Published: October 2023

Expanding the assortment of sour cream with increased nutritional value is an actual direction of scientific research. The purpose of the work is the scientific explanation of heating process duration based on the analysis of its influence on the sensory and physicochemical indicators of cream, enriched with milk protein concentrates as a basis for the production of baked sour cream. The regularities of changes in the quality indicators of cream (10–20 % fat), enriched with 1 % of concentrate of whey proteins (94 % total solids) and with 30 % of liquid concentrate of hydrolyzed whey (40 % total solids) under the influence of heat treatment at a temperature of 96±1 ⁰С for 15 to 120 minutes were determined. Due to the introduction of whey protein concentrate into the composition of cream, the protein content increases by 0.77 %, and in samples with liquid hydrolyzed whey concentrate by 0.42 %. Liquid hydrolyzed whey concentrate also increases the solid content in cream by 9.36–9.37 % while simultaneously reducing the lactose content by 6.2–6.7 times, which is promising for the production of low-lactose sour cream. Whey protein concentrate more effectively reduces surface tension, exhibits a higher stabilizing and structuring ability, compared to liquid hydrolyzed whey concentrate. Instead, the concentrate of liquid hydrolyzed whey with a high content of monosaccharides activates the Maillard reaction with the formation of an intense cream color, gives the cream a pronounced sweet taste and baked aroma. Both concentrates significantly improve the sensory properties of cream, which makes it possible to recommend them for use in baked sour cream technology. Based on the results of a comprehensive analysis of the quality indicators of baked cream samples with a fat content of 10–20 %, it was concluded that heat treatment of cream with liquid hydrolyzed whey concentrate and cream with whey protein concentrate should be carried for 15 minutes and 30 minutes, respectively, which will allow purposeful regulation of energy consumption in the technology of baked sour cream with increased protein content.
Periodical and non-periodical publications of spiritual Christians of the Molokans of the beginning of the XX century as a source on the history of Molokanism
Authors: Simonov V. V. , Frolov D. I.
Published: October 2023

The purpose of this article is to give a general overview of narrative sources of internal origin on the history of the religious movement of spiritual Christians of Molokans for 1905-1917, to establish the main types of these sources. The relevance of the article is due to the lack of source studies on the history of Molokanism, with the exception of brief reviews in dissertation research and monographs.
Formation and development of Orthodox rehabilitation pedagogy in relation to social orphans in Russia
Authors: Semyannikov S. N. , Savinykh L. N.
Published: October 2023

Historically, the Joseph Volokolamsk Monastery in all periods of its existence played a significant role not only in the spiritual, political, ideological, and economic life of Russia, but was also an important educational center. The monastery  continues  development  of  these  traditions,  founded  by  venerable  Joseph  Volotsky,  to  this  day.  The article examines a new phenomenon for Russia, social orphanhood, as a problem of modern society. Legislative acts defining the status of a social orphan and his relationship with society are given. Based on archival documents, a retrospective of the activities of the Joseph Volokolamsk Monastery in working with youth and helping orphans and the suffering is given. The historical aspects of Orthodox rehabilitation pedagogy in relation to orphans are indicated. Statistics of these activities and a historical retrospective of the relationship between the church and the state in the pre-revolutionary years and the years of Soviet power are given. The works of a number of Orthodox authors — teachers, ascetics, philosophers and educators, providing the basis for the development of Orthodox rehabilitation pedagogy — are examined in retrospective. The patristic foundations of the spiritual and moral education of modern teenagers — social orphans in Russia are indicated. The historical foundations and principles of modern educational, spiritual and moral rehabilitation mission of the brethren of the monastery in collaboration with the teams of social rehabilitation centers for minors are given. Individual programs for spiritual and moral rehabilitation of social orphans are offered.
On the concept, scope, history of Christian archeology and the significance of monumental studies for historical theology. Inauguration speech, given by taking the tenured chair on the of church history at the University of Freiburg-im-Breisgau of Prof. Dr. Franz Xaver Kraus. Freiburg-im-Breisgau, 1879
Authors: Buzykina Yu. N.
Published: October 2023

.
Systematic Literature Review of Publications on Digital Twin Topics in Certain Research Areas
Authors: ÖZAT Rabia , AKÇADAĞ Mualla
Published: October 2023

One of the key strategies adopted by companies that wish to compete in a sustainable fashion is the idea of the digital twin, which combines the physical product with virtual technology. The development of production models, cost reduction, and keeping up with shifting client wants and needs all depend on the digital twin. In this way, organizations can exhibit a development trend by utilizing the advancements in information and communication technologies, by utilizing techniques like the internet of things, big data, artificial intelligence, and the digital twin, coupled with other technologies. The systematic organization of prior studies on this topic is considered beneficial in terms of both illuminating the present trend and directing future study because the digital twin has grown in importance as a result of the development and dissemination of technology in every field. In this paper, a thorough literature assessment of digital twin research is intended. Vosviwer analysis was used to examine 60 studies from the Web of Science database that were published for this reason. Data on author partnerships, keyword density, support status, institution, country, language, citation, year, publication type, and field of study were investigated using Vosviwer analysis using the Web of Science database. The concept of the digital twin gained popularity as of 2019 when the years in which the studies in the Web of Science database were published were looked at. It was known that the majority of the associated studies were published in the USA, as articles, and in English. The analysis revealed that the most often used keywords in the 60 studies on digital twin were data, digital twin, and industry. According to the survey, research is primarily conducted in fields like smart production, supply chains, and business economy. The systematic literature review has led to an understanding that, in contrast to the domains of smart production, supply chain, and business economics, other topics are less investigated in transportation, public administration, economics, and social sciences. Publishing in less researched regions will close the gap in the literature in this direction.
Integrated Bioinformatics Analysis to Identify a Novel Four-Gene Prognostic Model of Breast Cancer and Reveal Its Association with Immune Infiltration
Authors: Zhu Yunhua , Luo Junjie , Yang Yifei
Published: October 2023

Liquid-liquid phase separation (LLPS) impact immune signaling in cancer and related genes have shown prognostic value in breast cancer (BRCA). However, the crosstalk between LLPS and immune infiltration in BRCA remain unclear. Therefore, we aimed to develop a novel prognostic model of BRCA related to LLPS and immune infiltration. BRCA-related, liquid-liquid phase separation (LLPS)-related genes, and differentially expressed genes (DEGs) were identified using public databases. Mutation and drug sensitivity analyses were performed using Gene Set Cancer Analysis database. Univariate cox regression and LASSO Cox regression were used for the construction and verification of prognostic model. Kaplan-Meier analysis was performed to evaluate overall survival (OS). Gene set variation analysis was conducted to analyze key pathways. CIBERSORT was used to assess immune infiltration and its correlation with prognostic genes was determined through Pearson analysis. A total of 6056 BRCA-associated genes, 3775 LLPS-associated genes, and 4049 DEGs, resulting in 314 overlapping genes. Twenty-eight prognostic genes were screened, and some of them were mutational and related to drug sensitivity Subsequently, a prognostic model comprising L1CAM, EVL, FABP7, and CST1 was built. Patients in high-risk group had shorter OS than those in low-risk group. The infiltrating levels of CD8+ T cells, macrophages M0, macrophages M2, dendritic cells activated, and mast cells resting was altered in high-risk group of breast cancer patients compared to low-risk group. L1CAM, EVL, FABP7, and CST1 were related to these infiltrating immune cells. L1CAM, EVL, FABP7, and CST1 were potential diagnostic biomarkers and therapeutic targets for BRCA.
Field Notes: Why We Need Eastern Europe?
Authors: Popescu Carmen , Kurg Andres , Stanek Lukasz , Bocharnikova Daria , Gourinovitch Oxana , Lähteenmäki Markus
Published: October 2023

These Field Notes map the impact that the Russian invasion of Ukraine has had on research in architectural history. We asked scholars already involved with Eastern Europe and Russia how the conflict has affected their approach to the region and to their work. In five responses to this question, these authors identify the need to dismantle conceptual and geopolitical frameworks that have been inherited from the late Soviet period, critically re-read the historiography of Russian avant- garde and constructivist architecture, and confront the question of postcolonial critique in Eastern Europe from a viewpoint in the Global South. Taken together, these notes from the field offer both immediate reactions from scholars to the terrible war in Ukraine and reflections on possible paths for architectural history writing in the aftermath of this shock.
Special Issue: Digital Truth-Making: Anthropological Perspectives on Right-wing Politics and Social Media in "Post-truth" Societies
Authors: Bareither Christoph , Harder Alexander , Eckhardt Dennis
Published: October 2023

How do users of social media platforms produce, shape and share truths online? In this introduction, we outline our understanding of digital truth-making as a process that builds on the affordances of digital infrastructures to entangle information with social, cultural and emotional dynamics in a way that co-constitutes beliefs and convictions about the world. The contributions to the special issue illuminate how different variations of this process can be illuminated with the help of digital ethnography and additional empirical methods. In doing so, they exemplify how digital anthropology can contribute to ongoing debates about populism and right-wing politics in “post-truth” digital societies.
Comparison of the effects of intraoperative remifentanil and sufentanil infusion on postoperative pain management in robotic gynecological surgery: a retrospective cohort study
Authors: Sung Tae-Yun , Jee Young Seok , Cho Sung-Ae , Huh Inho , Lee Seok-Jin , Cho Choon-Kyu
Published: October 2023

Background: Remifentanil and sufentanil are potent short-acting synthetic opioid analgesics. The administration of remifentanil has been associated with the incidence of opioid-induced hyperalgesia. Opioid-induced hyperalgesia may be alleviated when opioids, such as morphine, are switched to sufentanil. Therefore, this retrospective observational study aimed to compare the effects of remifentanil and sufentanil on postoperative pain in patients undergoing robotic gynecological surgery. Methods: We retrospectively analyzed the electronic medical records of patients who underwent elective robotic gynecological surgery between January 2016 and February 2021. The patients were classified into sufentanil (n = 159) or remifentanil (n = 359) groups according to the opioids administered continuously during anesthesia. The primary outcome assessed in this study was the postoperative pain score measured using the numeric rating scale (NRS). The secondary outcomes assessed included the recovery time (from discontinuation of opioid infusion to extubation) and frequency of rescue analgesic administration in the post-anesthesia care unit (PACU). Results: The recovery time did not differ significantly between the two groups. The NRS score for pain (median [1Q, 3Q]) in the PACU was significantly lower in the sufentanil group than in the remifentanil group (2 [2, 3] vs. 4 [3, 7], P < 0.001). The frequency of rescue analgesic administration in the PACU was 6.3% and 35.4% in the sufentanil and remifentanil groups, respectively (P < 0.001). Conclusions: Sufentanil, as an adjunct to sevoflurane anesthesia is more advantageous than remifentanil in terms of postoperative pain control during robotic gynecological surgery.
Feasibility of using red cell distribution width for prediction of postoperative mortality in severe burn patients: an association with acute kidney injury after surgery
Authors: Park Ji Hyun , Cho Seong-Sik , Jung Jongeun , Choi Seong-Soo
Published: October 2023

Background: Severe burns cause pathophysiological processes that result in mortality. A laboratory biomarker, red cell distribution width (RDW), is known as a predictor of mortality in critically-ill patients. We examined the association between RDW and postoperative mortality in severe burn patients.Methods: We retrospectively analyzed medical data of 731 severely burned patients who underwent surgery under general anesthesia. We evaluated whether preoperative RDW value can predict 3-month mortality after burn surgery using receiver operating characteristic (ROC) curve analysis, logistic regression, and Cox proportional-hazards regression analysis. Mortality was also analyzed according to preoperative RDW values and incidence of postoperative acute kidney injury (AKI). Results: The 3-month mortality rate after burn surgery was 27.1% (198/731). The area under the ROC curve of preoperative RDW to predict mortality after burn surgery was 0.701 (95% confidence interval [CI], 0.667–0.734; P < 0.001) with a cut-off point of 12.9. The adjusted hazard ratio in patients with RDW > 12.9 was 1.238 (95% CI, 1.138–1.347; P < 0.001). Subgroup analysis showed that the survival rate was 88.8% for the non-AKI group with RDW ≤ 12.9 and 17.6% for the AKI group with RDW > 12.9. Preoperative RDW was considered an independent risk factor for mortality (odds ratio, 1.679; 95% CI, 1.378–2.046; P < 0.001). Conclusions: Preoperative RDW may predict 3-month postoperative mortality in patients with severe burns, while preoperative RDW > 12.9 and postoperative AKI may further increase mortality after burn surgery.
Comparison of pain relief of the cervical radiculopathy between high thoracic erector spinae plane block and cervical epidural injection
Authors: Hong Ji Hee , Huh Se Nyung
Published: October 2023

Background: The high thoracic erector spinae plane block (ESPB) has been used for the management of chronic shoulder pain or arthroscopic shoulder surgery. No study has evaluated the analgesic efficacy of ESPB in patients with cervical radiculopathy although it is a favored and easy technique compared to neuraxial block. The purpose of this study was to compare the treatment outcome of cervical radiculopathy using high thoracic ESPB or cervical interlaminar epidural injection (CEPI).Methods: This study included 82 patients with neck and arm pain who received CEPI (CEPI group) using 4 ml of 0.1% ropivacaine or high thoracic ipsilateral ESPB (ESPB group) at the T2 or T3 level using 20 ml of 0.1% ropivacaine 20 ml. The degree of pain relief and disability were assessed using an 11-point numerical scale (NRS) and neck disability index (NDI), respectively.Results: The CEPI and ESPB groups demonstrated an equal number of patients with excellent pain relief (NRS reduction > 50%). Significant reduction of NRS was found in both groups, and the effect of time was statistically significant in the groups (P < 0.001). The number of patients who showed an excellent improvement in NDI (NDI reduction > 30%) was 20 (48.8%) and 22 (53.7%) in the CEPI and ESPB groups, respectively.Conclusions: Both the CEPI and ESPB demonstrated significant relief in neck and arm pain with improvement in disability.
A comprehensive review of difficult airway management strategies for patient safety
Authors: Jung Hoon
Published: October 2023

Difficult airway management is critical to ensuring patient safety. It involves addressing the challenges and failures that can occur, even with skilled healthcare providers, during face mask ventilation, intubation, supraglottic airway placement, invasive airway procedures, or extubation. Although the incidence of the most critical situation in airway management, “cannot intubate, cannot oxygenate,” is low at 0.0019–0.04%, its occurrence can have severe consequences, including dental injury, airway injury, hypoxic brain damage, and even death. This study aimed to offer healthcare providers a comprehensive and evidence-based approach for difficult airway management by reviewing recent guidelines and incorporating the latest evidence-based practices to improve their preparedness and competence in difficult airway management, and thus ultimately contribute to improved patient safety.
Section 1: Enzymatic DNA Fragmentation (Manually) v1
Authors: Kalef-Ezra Ester
Published: October 2023

This protocol details manual enzymatic DNA Fragmentation prior to Section 2: NGS library preparation for sequencing.
Zymo Protocol v1
Authors: Gailey Emily
Published: October 2023

Zymo Automation
ONT 16S Barcoding & Flow Cell Priming v1
Authors: Gailey Emily
Published: October 2023

This protocol describes how to carry out rapid barcoding of 16S amplicons using the 16S Barcoding Kit 1-24 (SQK-16S024). Due to the presence of both highly conserved (adequate for universal primers and phylogenetic signal) and highly variant regions (different across species), the 16S rRNA gene is often used for sequence-based bacterial identification. The 16S Barcoding Kit 1-24 enables access to rapid 16S sequencing for organism identification. By narrowing down to a specific region of interest, a user can see all the organisms in the sample without sequencing unneccesary regions of the genome, making the test quicker and more economical. There are 24 unique barcodes, allowing the user to pool up to 24 different samples in one sequencing experiment.
SureSelect XT HS2 DNA to prepare libraries for single-cell Whole Genome Sequencing (scWGS) after single-cell Whole Genome Amplification (scWGA) v1
Authors: Kalef-Ezra Ester
Published: October 2023

We adapted the SureSelect XT HS2 DNA protocol to prepare libraries using as input material samples after single-cell Whole Genome Amplification (scWGA), instead of genomic DNA samples, for library preparation for Illumina single-cell Whole Genome Sequencing (scWGS). This protocol can be employed either manually (Section 2: Option A) or in combination with automation using the Bravo Automated Liquid Handling Platform (Section 2: Option B).
Behavioral Beliefs about Acts of Academic Dishonesty: A study with Brazilian accounting students
Authors: Dutra Sallaberry Jonatas , Andrade dos Santos Edicreia , Flach Leonardo
Published: October 2023

This study seeks to identify, with the support of the Theory of Planned Behavior (TPB), individual behavioral beliefs that determine academic dishonesty behaviors. Qualitative research was conducted with Brazilian students and revealed their perceptions on academic dishonesty behaviors. According to the results, students perceive that fraud can lead to a better academic performance and less effort or time spent on academic tasks, but it can also result in punishment and embarrassment when it’s perceived by faculty, as well as impair learning and concerns about their future professional performance. The research contributes to the construction of an instrument for collecting and measuring beliefs, which can be considered as a relevant contribution to the literature and to understanding fraudulent behaviors.
Sleep quality and associated risk factors among youth attending health communication centre of a medical college in a rural area of Ujjain
Authors: Deshpande Kirti , Khardenavis Archit , Bhatnagar Dinesh
Published: October 2023

Background: Sound sleep is extremely important to maintain good health, especially for youth, as it is the most socio-economically productive age group of any community. Evidence suggests that poor sleep is associated with various physical and mental health problems. The present study aims to find out the quality of sleep, sleep disturbances, and associated risk factors among youth in a rural area of Ujjain.
Methods: Pittsburgh’s sleep quality index (PSQI) questionnaire was used to assess the sleep quality of young adults in the age group of 18-30 years attending health communication centre of a medical college.
Results: Mean PSQI Score of the study participants was 8.37±5.644. PSQI score for females was higher (7.076±5.49 vs 9.258±5.59) than PSQI Score of males. Majority (68.3%) had poor sleep quality but only few (11. 8%) self-rated their sleep quality as poor. Female gender and mobile phone addiction were the risk factors found significantly associated with poor sleep quality.   
Conclusions: Poor sleep quality among youth is an important concern as it has health consequences. Lack of self-awareness regarding sleep quality and mobile phone addiction among youth needs educational intervention.
Immunosensor for bovine anaplasmosis diagnosis on graphite platform functionalized with poly (3-hydroxybenzoic acid)
Authors: Ferreira Deusmaque Carneiro , Abrahão Júnior Odonírio , Oliveira Júnior Robson Tadeu Soares de , Souza Santos Paula de , Brito Madurro Ana Graci , Madurro João Marcos
Published: October 2023

This study describe the development of an electrochemical immunosensor with a transducer platform functionalized with the poly-(3- hydroxybenzoic acid), to detection of antibodies against the surface protein (Am1) of Anaplasma marginale. This biological probe was immobilized on the polymer under graphite and characterized electrochemically. The detections of antigen-antibody interactions were conducted using the signal obtained from the oxidation of 4-aminoantipyrine (4 -AAP), interleaved with Am1, to enable the use of voltammetry technique of differential pulse. The detections of antibodies of A. marginale, using the graphite electrode functionalized with the probe Am1 was 66% higher than the graphite electrode not functionalized. The time of storage of the immunosensor was satisfactory, with reduced peak current by 35%, after 90 days. The results demonstrate the excellent applicability of this new functionalized platform for probe immobilization and diagnosis of anaplasmosis without the interference of the most similar bovine diseases
Minimally invasive dentistry: history, theory and perspectives
Authors: Jargin S. V.
Published: October 2023

The article is a literature review concerning certain aspects of the history of Russian dentistry. In this regard, minimally invasive methods are discussed, including air-abrasive, laser, sonic and ultrasonic preparation, as well as atraumatic restorative treatment without mechanical preparation. Indications for minimally invasive methods, assessment of caries activity and prognosis, causes and mechanisms of the accelerated restoration cycle are discussed. The need to preserve dental tissues has been undervalued in the past. Non-selective preparation to hard dentin is currently considered hypertherapy. The concept of minimally invasive dentistry is also applied in endodontics and periodontology. In patients with gingival recession, it is important to protect atrophic tissues from further damage. After a tooth extraction, excessive socket curettage should be avoided. The research in dentistry should be protected from conflicts of interest. Patients should be objectively informed about treatment options, given recommendations based on clinical indications, wishes and possibilities. It is also necessary to develop economic measures in order to reorient private dental clinics to receive patients with compulsory medical insurance and the use of minimally invasive methods.