bluuebunny/crossref_metadata_2025 huggingface dataset:
Diffuse B-cell lymphoma in a child with HIV infection
Authors: Khaertynov Kh. S. , Anokhin V. A. , Khaliullina S. V. , Osipova I. V. , Shapiro V. Yu. , Petrov S. V. , Idrisov I. G. , Bulatova A. Kh. , Raimova Yu. A.
Published: December 2021

Objective. To describe the case of diffuse B-cell lymphoma in a child with HIV infection.

Results. A 16-year-old child with HIV infection and generalized lymphadenopathy was diagnosed with diffuse large B-cell lymphoma, stage III, negative central nervous system. The patient was diagnosed on the basis of the results of immunohistochemical study of biopaths of the tissue of the lymph nodes of the submandibular and right axillary region. The study in order to identify markers of active infection caused by the Epstein-Barr virus, cytomegalovirus and human herpesvirus type 6, made it possible to exclude the active phase of diseases that are the main infectious causes of lymphoproliferative syndrome. At the time of hospitalization, the patient was treated with antiretroviral therapy of the combined drug Eviplera. There was no HIV RNA in the blood, the level of CD4 lymphocytes was 0.4·109/l. The BFM chemotherapy regimen was used, which was accompanied by positive dynamics in the form of normalization of body temperature, reduction in the size of lymph nodes.

Conclusion. This case shows that immunohistochemical examination of tissue biopsies of enlarged lymph nodes is of decisive importance in the diagnosis of lymphoma, the main non-infectious cause of lymphoproliferative syndrome in patients with HIV infection.
Idiopathic hemosiderosis of the lung tissue
Authors: Sadykova D. I. , Makarova T. P. , Shakirova A. R. , Sayfullina R. M. , Sayfieva R. D. , Khusnutdinova D. R. , Khabibrakhmanova Z. R.
Published: December 2021

Idiopathic hemosiderosis of lung tissue is a rare disease with lung damage caused by massive hemorrhage into the lung tissue, with iron-containing hemosiderin deposition. Mainly it occurs in childhood. The article describes the clinical case of idiopathic hemosiderosis of lung tissue in a 3 years 11 months old child. The girl was observed for anemia of unclear etiology, she was repeatedly treated at a hospital and received erythrocyte transfusions. In the future, respiratory syndrome joined the anemic syndrome. It should be noted that a correctly collected anamnesis, timely diagnosis of the disease and the appointment of immunosuppressive therapy make it possible to prevent the rapid progression of the process and the development of complications, including pneumosclerosis.
Diagnosis of pulmonary hypertension associated with congenital heart disease. Part 1. Definition, classification and initial examination of patients
Authors: Gorbachevsky S. V. , Shmalts A. A.
Published: December 2021

Having discussed current definitions and classification of pulmonary hypertension associated with congenital heart defects, the authors consider characteristic clinical symptoms and data of physical examination separately for every subgroup. An increase in pulmonary vascular resistance after radical correction and with small / concomitant defects leads to insufficient filling of the systemic ventricle and the progression of symptoms of low cardiac output , i.e. shortness of breath, palpitations, fatigue, weakness and decreased exercise tolerance. At late stages, due to transient systemic hypotension the patients feel dizziness, lightheadedness and fainting, as well as signs of congestive right ventricular failure – peripheral edema, liver enlargement, ascites and swelling of the cervical veins. The patients with Eisenmenger syndrome develop cyanosis and signs of systemic complications – polycythemia, deformation of the distal phalanges of the fingers like «drumsticks» and «watch glasses», posture disturbance due to osteoarthropathy and scoliosis, pulmonary and paradoxical systemic thrombosis and embolism, bleeding, symptoms of gout and cholelithiasis, impaired renal function. Even mild pulmonary hypertension after Fontaine’s surgery causes venous hypertension with congestive heart failure, hydrothorax, protein deficiency enteropathy and plastic bronchitis, as well as insufficient blood flow to the systemic ventricle with low cardiac output, shortness of breath, palpitations, fatigue, weakness and decreased exercise tolerance. All forms of pulmonary hypertension cause pain in the region of the heart, hemoptysis, pulmonary hemorrhage, arrhythmias, and developmental delay in children. The patient shall be examined «from head to toe.» The diagnostic value of auscultation depends on the complexity of the congenital malformation leading to pulmonary hypertension Pulse oximetry should be performed separately on the arms and legs at rest and exercise.
Anatomical tracheal parameters in premature neonates with birth body weight less than 1000 g for effective and safe administration of surfactant
Authors: Mostovoy A. V. , Zhakota D. A. , Karpova A. L. , Karpov N. Yu. , Karpov L. N. , Volodin N. N.
Published: December 2021

Objective. To evaluate anatomical tracheal parameters of fetus and premature infant for clarifying the permissible and safe depth of insertion and «thin catheter» diameter during minimally invasive administration of surfactant.

Material and methods. Autopsy examination of fetuses and newborns with extremely low birth weight, who died during their first 168 hours of life. The study describes only 26 cases, respiratory system malformations are excluded. The authors measured the distance from the glottis to the bifurcation, the perimeter of the trachea under the ligaments, in the middle part and at the level of the bifurcation with the calculation of the trachea diameter.

Results. The average body weight was 684.6 ± 160.8 g, gestational age varied from 21 to 33 weeks and averaged 25 weeks. The distance from the glottis to the bifurcation was 34.31 ± 5.28 mm, and the diameter in the upper, middle and lower thirds was 3.53 ± 0.64 mm, 3.41 ± 0.63 and 3.69 ± 0.78 mm respectively

Application of the results: registration of these indicators when choosing a catheter for minimally invasive administration of a surfactant and the depth of its introduction into the trachea in newborns with extremely low body weight will help to avoid such complications, as one-lung administration of surfactant and its regurgitation from the trachea during the procedure, thereby increasing the efficiency and safety of the method

Conclusion. The length and diameter of trachea in neonates with extremely low birth weight in the early neonatal period depend on anthropometric values and gestational age at birth, mean length is 34.31±5.28 mm.
Clinical characteristics and cellular immunity in children with rotavirus infection
Authors: Gorbunov S. G. , Mazankova L. N. , Oskin A. N. , Lugovskaya S. A. , Naumova E. V. , Pochtar M. E.
Published: December 2021

Objective. To determine clinical course and state of cellular immunity in young children with rotavirus infection.

Children characteristics and research methods. The scientists examined children without infectious pathology and with rotavirus infection (20 patients in each group) using general clinical methods. Rotavirus infection was diagnosed by polymerase chain reaction and immunochromatography. Cellular immunity parameters were determined by flow cytometry.

Results. All the children under observation had a moderate form of the disease with symptoms of exsicosis of the II degree. Changes in the immune status were mainly of a regulatory, adaptive nature, which contributed to the favorable course of rotavirus infection in children, however, the dynamics of the number of cells expressing Toll-like receptors indicates the immunosuppressive properties of rotavirus.

Conclusion. Currently, rotavirus infection in young children is typical with watery diarrhea as the most pronounced and long-lasting clinical symptom. Shifts in immunogram indices in general indicate a deficiency of the cellular link of immunity and a violation of its regulation with simultaneous activation of the immune system in an effort to achieve the eradication of the rotavirus with immunosuppressive properties.
Approximate approach for improving pressure attenuation accuracy during hydraulic transients
Authors: Yu Chao , Yu Xiaodong , Zhang Lei , Neupane Bhusan , Zhang Jian
Published: December 2021

The quasi-steady friction model is generally adopted in water hammer simulation in pipe network systems, which cannot accurately reflect the attenuation of pressure, while the existing unsteady friction model is challenging to use in complex pipe network systems. In this study, a convenient method for treating the friction term is proposed based on the Moody diagram. The attenuation process of water hammer pressure can be accurately reflected by reading the relationship curve between Reynolds number and the Darcy friction factor in the pipeline transient process. Combined with the classical water hammer experiment and the long pipe valve closing experiment in our laboratory, the accuracy of this model is verified, and the influence of absolute roughness (e) and Reynolds number (Re) on the model was analyzed as well. The results show that the pressure attenuation using the Method of Characteristics (MOC) and the proposed friction model has a good agreement with the experimental data. The absolute roughness has little influence on the results in hydraulically smooth pipe, while the minimum Reynolds number has a significant influence. When selecting the minimum Reynolds number, 2% ∼ 5% of the initial flow rate is recommended for calculation.
Optimization of multiple parameters for adsorption of arsenic (III) from aqueous solution using Psidium guajava leaf powder
Authors: Behera Uma Sankar , Mishra Prakash Chandra , Radhika G. B.
Published: December 2021

The conventional method of water treatment using activated carbon from several sources has been focused on extensively in the last two decades. However, rare attention has been noticed on natural adsorbents such as plant leaves. Therefore, the Psidium guajava (guava) leaf has been investigated to understand its adsorption efficacy for Arsenic (III) [As(III)] in this study. The effect of process variables, e.g., pH, concentration of metal ion, adsorbent's particle size, and dosages, are evaluated. Experiments are carried out in batch mode, and the individual and combined parameter's impact on adsorption have been discussed. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) is used to characterize the adsorbent's surface. Freundlich and Langmuir's isotherms are used for adsorption equilibrium study. The adsorption parameters are optimized by establishing a regression correlation using central composite design (CCD) of response surface methodology (RSM). The analysis of variance (ANOVA) suggests a high regression coefficient (R2 = 0.9249) for the removal of As(III). Particle size of 0.39 mm; adsorbent's height of 10 cm; metal ion concentration of 30 ppm, and pH 6 are optimized to remove 90.88% As(III) from aqueous solution. HCl is evaluated as a potential solvent for desorption of arsenic from the desorption study.
Emerging Trends in Abuse-Deterrent Formulations: Technological Insights
and Regulatory Considerations
Authors: Benival Derajram , Rana Dhwani , Salave Sagar
Published: December 2021

Background:

Opioid medications are an integral part of the management of acute and
chronic severe pain. However, non-medical practice of these prescription drug products is emerging
as a serious public health problem. To control this opioid epidemic, USFDA is encouraging
pharmaceutical companies to develop Abuse Deterrent Formulations (ADFs). ADF's are much
more difficult to manipulate and abuse when compared to their conventional formulations. This feature
of ADFs is due to their ability to incumber extraction of active ingredients, to prevent administration
through alternative routes, making abuse of altered product less rewarding.

Objective:

The main objective of this review is to abridge different ADFs and various laboratory-
based in vitro manipulation and extraction studies, demonstrating that these approved ADFs
have the capabilities to deter abuse.

Methods:

The method includes the collection of data from different search engines like PubMed,
FDA guidance documents, ScienceDirect, Google Patents to get coverage of literature in order to
get appropriate information regarding ADFs.

Results:

Various in vitro studies demonstrate that ADFs are effective in minimizing opioid drug
abuse, including opioid overdose. However, real impact of these ADFs on reducing the drug abuse
can be concluded only after receiving the post marketing data.

Conclusion:

ADFs are embracing fundamentally different paradigms in the management of severe
pain. We believe that the development of abuse deterrent technologies would shift the architype, deterring
multipill abuse and can prove as a breakthrough strategy in controlling this opioid epidemic
menace.
Mitochondrial Dysfunction as a Causative Factor in Alzheimer’s Disease-Spectrum Disorders: Lymphocytes as a Window to the Brain
Authors: Jörg Marko , Plehn Johanna E. , Friedland Kristina , Müller Walter E.
Published: December 2021

Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease.
Today, AD affects millions of people worldwide and the number of AD cases will further increase
with longer life expectancy. The AD brain is marked by severe neurodegeneration, such as the loss
of synapses and neurons, atrophy and depletion of neurotransmitter systems, especially in the hippocampus
and cerebral cortex. Recent findings highlight the important role of mitochondrial dysfunction
and increased oxidative stress in the pathophysiology of late-onset alzheimer’s disease
(LOAD). These alterations are not only observed in the brain of AD patients but also in the periphery.
In this review, we discuss the potential role of elevated apoptosis, increased oxidative stress
and mitochondrial dysfunction as peripheral markers for the detection of AD in blood cells e.g.
lymphocytes. We evaluate recent findings regarding impaired mitochondrial function comprising
mitochondrial respiration, reduced complex activities of the respiratory chain and altered Mitochondrial
Membrane Potential (MMP) in lymphocytes as well as in neurons. Finally, we will question
whether these mitochondrial parameters might be suitable as an early peripheral marker for the detection
of LOAD but also for the transitional stage between normal aging and Dementia, “Mild
Cognitive Impairment” (MCI).
Is Sunflower Cooking Oil Beneficial for Colorectal Cancer? In Vivo
Studies on Azoxymethane-induced Colon Cancer in Rats
Authors: David Sheba R. Nakka , Mohammad Miza Syazwina , Chee Lim Ya , Rajabalaya Rajan
Published: December 2021

Background:

The incorporation of oils in the diet may have promoting or inhibitory
effects on Colorectal Cancer (CRC). In this study, azoxymethane (AOM) was used to mimic CRC
in rats, and the effect of sunflower oil on cancer progression in the colon of the rats was tested.

Objective:

This study was conducted to investigate the effect of sunflower oil on preneoplastic
cancer properties of the colonic mucosal surface of tumors and the aberrant crypt foci (ACF).

Methods:

Six-week-old Sprague-Dawley male rats were randomized into 4 groups of 6 rats each,
namely naïve, positive control, negative control, and sunflower oil-fed. CRC was induced by AOM
by subcutaneous injection of 20 mg/kg. After CRC induction, the rats were given the respective
treatment of either basal diet (naïve group), 10 mg/kg indomethacin (positive control), 0.9 % saline
(negative control), or 7 % sunflower oil (experimental group) daily by oral gavage for 42 days.
Rats were sacrificed by cervical dislocation; colon samples were visually observed for any tumors
on the colonic mucosal surface and evaluated for ACF; histopathological examinations were also
performed.

Results:

The mean body weights of the rats were similar in all groups as per one-way ANOVA. A
total of 3 ACF were found in the negative group, while none were observed in other groups. The
crypts appeared regular with circular luminal openings and were closely packed together in the
naïve group. Crypts in the positive and treated group had a similar appearance to the naïve group.

Conclusion:

Sunflower oil inhibition of the preneoplastic cancer ACF properties were tested but
were found to be insignificant when administered during CRC treatment or management. However,
long-term experiments with a greater number of days will yield better development of tumor
and ACF development and will be useful in identifying the molecular mechanism.
Efficacy and Complications of Subcutaneous versus Conventional Cardioverter
Defibrillators: A Systematic Review and Meta-analysis
Authors: Araújo Camilla Silva , Silva Carla Liz Barbosa , da Silva Menezes Júnior Antônio , Barbosa Vinícius Araújo , de Almeida Laranjeira Tiago , Fernandes Joaquim Ferreira , Gonçalves Lucas Cândido , Silva Antonio Márcio Cordeiro
Published: December 2021

Background/Objectives:

Implantable cardioverter defibrillators are used to prevent sudden
cardiac death. The subcutaneous implantable cardioverter-defibrillator was newly developed to
overcome the limitations of the conventional implantable cardioverter defibrillator-transvenous device.
The subcutaneous implantable cardioverter defibrillator is indicated for young patients with
heart disease, congenital heart defects, and poor venous access, who have an indication for implantable
cardioverter defibrillator without the need for anti-bradycardic stimulation. We aimed to
compare the efficacy and complications of subcutaneous with transvenous implantable cardioverter-
defibrillator devices.

Methodology:

A systematic review was conducted using different databases. The inclusion criteria
were observational and clinical randomized trials with no language limits and no publication date
limit that compared subcutaneous with transvenous implantable cardioverter-defibrillators. The selected
patients were aged > 18 years with complex ventricular arrhythmia.

Results:

Five studies involving 2111 patients who underwent implantable cardioverter defibrillator
implantation were included. The most frequent complication in the subcutaneous device group was
infection, followed by hematoma formation and electrode migration. For the transvenous device,
the most frequent complications were electrode migration and infection. Regarding efficacy, the total
rates of appropriate shocks were 9.04% and 20.47% in the subcutaneous and transvenous device
groups, respectively, whereas inappropriate shocks to the subcutaneous and transvenous device
groups were 11,3% and 10,7%, respectively.

Conclusion:

When compared to the transvenous device, the subcutaneous device had lower complication
rates owing to lead migration and less inappropriate shocks due to supraventricular tachycardia;
nevertheless, infection rates and improper shocks due to T wave oversensing were comparable
for both devices CRD42021251569.
The development of government support for compliance managers training in Russian Federation
Authors: Kazakov Alexander Sergeevich , Prodanova Natalia Aлексеевна , Sotnikova Lyudmila Viktorovna , Plaskova Nataliya Stepanovna , Prokofieva Elena Vasilievna , Khamkhoeva Fatima Yahievna
Published: December 2021

The article reflects ?n the problems of government support for the training of compliance officers in the Russian Federation. This problem became more acute in connection with the consolidation in clause 3 of the Order of the Government of the Russian Federation No. 1697-r of August 16, 2018, the requirement to create internal systems under state and municipal authorities, ensuring that their activities comply with the requirements of antimonopoly legislation. The lack of theoretical and practical knowledge of civil servants in this area (the area of compliance) determines the relevance of the problem under consideration. This mostly concerned t? yesterday's students who are unable to provide payment ?f additional education in this area due to lack of financial resources. This entails the lack of qualifications of civil servants in the area of compliance and the ineffectiveness of compliance programs they are running. In the course of the study, we concluded that it is necessary to adopt in Russia a Scandinavian approach of government support for the training of labor resources at the expense of the national budget and taking into account the real need for labor resources in regions and municipalities.
Исследование диэлектрических функций слоя наночастиц Ag на кремнии с помощью спектроэллипсометрии и спектрофотометрии
Authors: Толмачев В.А. , Жарова Ю.А. , Ермина А.А. , Большаков В.О.
Published: December 2021

An investigation of the optical characteristics of a layer of Ag nanoparticles deposited from an AgNO3 solution on the surface of single-crystal Si is presented. The measurements were carried out using spectroscopic ellipsometry and spectrophotometry at the same tilt angle and sample probe location in a wide spectral range from 200 to 1700 nm. From the obtained experimental data, the parameters of the Drude-Lorentz model and the complex dielectric function were determined, which was compared with the pseudo-dielectric function. Both dependences revealed resonances of a bulk plasmon near the energy E = 3.8 eV, while a localized plasmon was detected in the pseudo-dielectric function at E = 1.65 eV, and in the dielectric function at E = 1.84 eV.
Люминесценция дитолуоилметаната дифторида бора. Образование J-агрегатов
Authors: Мирочник А.Г. , Федоренко Е.В. , Белолипцев А.Ю.
Published: December 2021

The processes of the formation of J-aggregates during the dissolution 2,2-difluoro-4,6-di(4’-methylphenyl)-1,3,2-dioxaborine crystals (1) and their subsequent dissociation have been studied by absorption and luminescence spectroscopy and quantum-chemical modeling. It is shown that two luminescent centers are observed in the solution 1: monomeric luminescence and luminescence of J-aggregates (dual luminescence). Evolution of absorption, luminescence excitation and luminescence spectra is observed over time, indicating a slow dissociation of J-aggregates.
The Novel Data Collection and Analytics Tools for Remote Patient Monitoring in Heart Failure (Nov-RPM-HF) Trial: Protocol for a Single-Center Prospective Trial
Authors: Bhatia Ankit , Ewald Gregory , Maddox Thomas
Published: December 2021

Background

Heart failure remains a leading cause of mortality and a major driver of health care utilization. Despite numerous medical advances in heart failure, associated hospitalizations continue to increase, owing largely to suboptimal outpatient management. Remote patient monitoring (RPM) aims to further address this current need in heart failure care by providing data to clinical teams to act pre-emptively to address clinical decompensation. However, to date, RPM approaches using noninvasive home-based patient sensors have failed to demonstrate clinical efficacy.

Objective

The Novel Data Collection and Analytics Tools for Remote Patient Monitoring in Heart Failure (Nov-RPM-HF) Trial aims to address current noninvasive RPM limitations. Nov-RPM-HF will evaluate a clinician co-designed RPM platform using emerging data collection and presentation tools for heart failure management. These tools include a ballistocardiograph to monitor nocturnal patient biometrics, clinical alerts for abnormal biometrics, and longitudinal data presentation for clinician review.

Methods

Nov-RPM-HF is a 100-patient single-center prospective trial, evaluating patients over 6 months. The outcomes will include patient adherence to data collection, patient/clinician-perceived utility of the RPM platform, medication changes including the titration of guideline-directed medical therapy to target doses, heart failure symptoms/performance status, and unplanned heart failure hospitalizations or emergency department visits.

Results

This prospective trial began enrollment in March 2020 and anticipates enrollment completion by June 2022, with trial completion by December 2022.

Conclusions

This trial protocol aims to provide a systematic framework for the evaluation of heart failure RPM strategies, which are currently heavily used but seldom robustly studied. The trial results will help to inform the role of noninvasive RPM as a viable clinical management strategy in heart failure care.

International Registered Report Identifier (IRRID)

DERR1-10.2196/32873
Remote Electroencephalography Monitoring of Epilepsy in Adults: Protocol for a Scoping Review
Authors: Milne-Ives Madison , Shankar Rohit , McLean Brendan , Duun-Henriksen Jonas , Blaabjerg Lykke , Meinert Edward
Published: December 2021

Background

Electroencephalography (EEG) monitoring is a key tool in diagnosing and determining treatment for people with epilepsy; however, obtaining sufficient high-quality data can be a time-consuming, costly, and inconvenient process for patients and health care providers. Remote EEG monitoring has the potential to improve patient experience, data quality, and accessibility for people with intellectual or developmental disabilities.

Objective

The purpose of this scoping review is to provide an overview of the current research evidence and knowledge gaps regarding the use of remote EEG monitoring interventions for adults with epilepsy.

Methods

The PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) and Population, Intervention, Comparator, Outcome, and Study (PICOS) frameworks will be used to structure the review. Searches will be conducted in 6 databases (PubMed, MEDLINE, Embase, CINAHL, Web of Science, and ClinicalTrials.gov) for articles published in English that evaluate at least one out-of-hospital EEG monitoring intervention or device for adults with epilepsy. A descriptive analysis will be conducted to summarize the results; key themes and gaps in the literature will be discussed.

Results

Results will be included in the scoping review, which will be submitted for publication by April 2022.

Conclusions

This scoping review will summarize the state of the field of remote EEG monitoring interventions for adults with epilepsy and provide an overview of the strengths, weaknesses, and gaps in the research.

International Registered Report Identifier (IRRID)

PRR1-10.2196/33812
Implementation, Adoption, and Perceptions of Telemental Health During the COVID-19 Pandemic: Systematic Review (Preprint)
Authors: Appleton Rebecca , Williams Julie , Vera San Juan Norha , Needle Justin J , Schlief Merle , Jordan Harriet , Sheridan Rains Luke , Goulding Lucy , Badhan Monika , Roxburgh Emily , Barnett Phoebe , Spyridonidis Spyros , Tomaskova Magdalena , Mo Jiping , Harju-Seppänen Jasmine , Haime Zoë , Casetta Cecilia , Papamichail Alexandra , Lloyd-Evans Brynmor , Simpson Alan , Sevdalis Nick , Gaughran Fiona , Johnson Sonia
Published: December 2021

BACKGROUND

Early in 2020, mental health services had to rapidly shift from face-to-face models of care to delivering the majority of treatments remotely (by video or phone call or occasionally messaging) due to the COVID-19 pandemic. This resulted in several challenges for staff and patients, but also in benefits such as convenience or increased access for people with impaired mobility or in rural areas. There is a need to understand the extent and impacts of telemental health implementation, and barriers and facilitators to its effective and acceptable use. This is relevant both to future emergency adoption of telemental health and to debates on its future use in routine mental health care.

OBJECTIVE

To investigate the adoption and impacts of telemental health approaches during the COVID-19 pandemic, and facilitators and barriers to optimal implementation.

METHODS

Four databases (PubMed, PsycINFO, CINAHL, and Web of Science) were searched for primary research relating to remote working, mental health care, and the COVID-19 pandemic. Preprint servers were also searched. Results of studies were synthesized using framework synthesis.

RESULTS

A total of 77 papers met our inclusion criteria. In most studies, the majority of contacts could be transferred to a remote form during the pandemic, and good acceptability to service users and clinicians tended to be reported, at least where the alternative to remote contacts was interrupting care. However, a range of impediments to dealing optimal care by this means were also identified.

CONCLUSIONS

Implementation of telemental health allowed some continuing support to the majority of service users during the COVID-19 pandemic and has value in an emergency situation. However, not all service users can be reached by this means, and better evidence is now needed on long-term impacts on therapeutic relationships and quality of care, and on impacts on groups at risk of digital exclusion and how to mitigate these.

CLINICALTRIAL

PROSPERO International prospective register of systematic reviews CRD42021211025; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021211025
Continued use of mobile apps for health promotion (Preprint)
Authors: Miranda Beatriz , Oliveira Tiago , Dias Sara Simões
Published: December 2021

BACKGROUND

Mobile health (mhealth) applications (apps) promotion has been increasingly used year after year. They have recently played an important role in preventing an unhealthy society. Mhealth apps have been developed in different health areas, increasingly satisfying user goals.

OBJECTIVE

This study aimed to explore and understand important factors that contribute to use behavior and the intention to continue using mhealth apps, in combination with the self-determination theory, and produce well-being and consciousness in health. This study extends the findings to continue usage, along with the intrinsic motivation of each consumer that drives well-being.

METHODS

The proposed model was empirically tested using data from a survey. We obtained 306 valid responses through an online questionnaire created in Qualtrics from participants that use mhealth apps. We applied the partial least squares structural equation modelling (PLS-SEM) technique to test the research model.

RESULTS

The results show that the drivers of intrinsic motivation with statistical significance were perceived autonomy ((β ) ̂= 0.23; P < .001), perceived relatedness (β ̂ = 0.11; P = 0.049) and perceived competence (β ̂ = 0.50; P < .001). The drivers of perceived usefulness with statistical significance were confirmation (β ̂ = 0.74; P < .001). The precursors of satisfaction that were statistical significance were confirmation (β ̂ = 0.66; P < .001) and perceived usefulness ((β ) ̂= 0.22; P < .001). Use behavior was significantly influenced by intrinsic motivation (β ̂ = 0.58; P < .001) and perceived usefulness (β ̂ = 0.32; P < .001). The drivers of continuance intention to use with statistical significance were intrinsic motivation (β ̂ = 0.12; P = .018), perceived usefulness (β ̂ = 0.14; P = .004), satisfaction (β ̂ = 0.48; P < .001) and use behavior (β ̂ = 0.22; P < .001). Well-being was significantly influenced by use behavior (β ̂ = 0.62; P < .001) and continuance intention to use (β ̂ = 0.19; P = .001). The moderation effect of health consciousness in the relationship between use behavior and well-being (β ̂ = 0.14; P = .006) was statistically significant but the relationship between continuance intention to use and well-being (β ̂ = -0.06; P = .22), was not statistically significant. Therefore, the model explained over 50.8% of the total variance in intrinsic motivation, 54,4% of the variance in perceived usefulness, 69.6% of the variance satisfaction, 62.2% of the variance use behavior, 73.6% of the variance continuance intention to use, and 65.6% of the variance well-being.

CONCLUSIONS

Our study contributes to the continuance theory of the use of mhealth apps. The model found that intrinsic motivation, satisfaction, perceived usefulness, and user behavior significantly affect continuance intention. Our study demonstrates a significant role in a society that uses mhealth apps and that their use reflects well-being with the moderation effect of health consciousness.
The Impact of Transitioning From In-Person to Virtual Heart Transplantation Selection Committee Meetings: Observational Study (Preprint)
Authors: Shan Rongzi , Chandra Neha V , Hsu Jeffrey J , Fraschilla Stephanie , Moore Melissa , Ardehali Abbas , Nsair Ali , Parikh Rushi V
Published: December 2021

BACKGROUND

Heart transplant selection committee meetings have transitioned from in-person to remote video meetings during the COVID-19 pandemic, but how this impacts committee members and patient outcomes is unknown.

OBJECTIVE

The aim of this study is to determine the perceived impact of remote video transplant selection meetings on usability and patient care and to measure patient selection outcomes during the transition period from in-person to virtual meetings.

METHODS

A 35-item anonymous survey was developed and distributed electronically to the heart transplant selection committee. We reviewed medical records to compare the outcomes of patients presented at in-person meetings (January-March 2020) to those presented during video meetings (March-June 2020).

RESULTS

Among 83 committee members queried, 50 were regular attendees. Of the 50 regular attendees, 24 (48%) were physicians and 26 (52%) were nonphysicians, including nurses, social workers, and coordinators; 46 responses were received, 23 (50%) from physicians and 23 (50%) from nonphysicians, with 41 responses fully completed. Overall, respondents were satisfied with the videoconference format and felt that video meetings did not impact patient care and were an acceptable alternative to in-person meetings. However, 54% (22/41) preferred in-person meetings, with 71% (15/21) of nonphysicians preferring in-person meetings compared to only 35% (7/20) of physicians (P=.02). Of the 46 new patient evaluations presented, there was a statistically nonsignificant trend toward fewer patients initially declined at video meetings compared with in-person meetings (6/24, 25% compared to 10/22, 45%; P=.32).

CONCLUSIONS

The transition from in-person to video heart transplant selection committee meetings was well-received and did not appear to affect committee members’ perceived ability to deliver patient care. Patient selection outcomes were similar between meeting modalities.
High Prevalence of Mental Disorder Symptoms Among Medical and Other Health Specialty Residents During the COVID-19 Pandemic (Preprint)
Authors: Silva Nayane Miranda , Lucena Pinho Rebeca da Nobrega , Ferreira Costa Thais , Barros Areal Adriana Ferreira , Salles André De Mattos , Alves Oliveira Andrea Pedrosa Ribeiro , Reis Esselin Rassi Carlos Henrique , Brero Valero Caroline Elizabeth , Gomes Ciro Martins , Mendonça da Silva Dayde Lane , Rodrigues de Oliveira Fernando Araujo , Jochims Isadora , Ranulfo Vaz Filho Ivan Henrique , Seixas Neves Juliana De Brito , Oliveira Lucas Alves de Brito , Nogueira Dantas Maria Luisa , Rosal Marta Alves , Soares Mayra Veloso Ayrimoraes , Kurizky Patrícia Shu , Uliana Peterle Viviane Cristina , Faro Yasmin Furtado , Gomides Ana Paula Monteiro , Henrique da Mota Licia Maria , Albuquerque Cleandro Pires de , Simaan Cezar Kozak , Amado Veronica Moreira
Published: December 2021

BACKGROUND

The coronavirus (SARS-CoV-2) epidemic was first identified in Wuhan, China, at the end of 2019, and spread across the world in a fast and disordered manner. Because of the pandemic, health professionals, including residents in medicine and other health specialties, began working under intense physical and psychological pressure daily and were exposed to a greater risk of developing mental disorders and psychological distress.

OBJECTIVE

This study evaluated the prevalence of symptoms indicative of mental disorders such as depression, anxiety and stress among postgraduate students who were residents in medicine and other health specialties during the COVID-19 pandemic in Brazil and identified possible associated predisposing factors.

METHODS

This was a cross-sectional study that included postgraduate students in medical and other health residency programmes in Brazil. The recruitment period was from July 29 to September 5, 2020. Epidemiological and clinical data, including evaluations of psychological and affective aspects, following a predefined protocol, were collected after the participants filled out an electronic form via the Microsoft Forms platform.

RESULTS

In total, 1,313 medical and other health residents participated in the study. The Depression, Anxiety and Stress Scale-21 (DASS-21) identified depression, anxiety and stress in 51.3%, 53.4% and 52.6% of the participants, respectively. Based on the Brief Resilient Coping Scale (BRCS), 61.9% of the participants had low resilience. A total of 60.9% of the residents had high scores on the Patient Health Questionnaire 9‐item depression module (PHQ-9).

CONCLUSIONS

We found a high prevalence of symptoms of depression, anxiety and stress among medical and non-medical residents during the COVID-19 pandemic in Brazil. Mental disorders are complex in nature, and the particular academic environment of residency, altered by the need to care for patients with COVID-19, can be a potential stressor and be associated with the high prevalence of these symptoms among residents.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/24298
Assessment of Seismogeodynamic Activity of Mining Areas on the Basis of 3D Geoinformation Modeling
Authors:   Institute of Geology of Ore Deposits, Petrography, Mineralogy and Geochemistry Russian Academy of Sciences (IGEM RAS), Staromonetny Pereulok, 35, Moscow, Russia, Petrov V. A. , Minaev V. A. ,   Institute of Geology of Ore Deposits, Petrography, Mineralogy and Geochemistry Russian Academy of Sciences (IGEM RAS), Staromonetny Pereulok, 35, Moscow, Russia, Ustinov S. A. ,   Institute of Geology of Ore Deposits, Petrography, Mineralogy and Geochemistry Russian Academy of Sciences (IGEM RAS), Staromonetny Pereulok, 35, Moscow, Russia, Nafigin I. O. ,   Institute of Geology of Ore Deposits, Petrography, Mineralogy and Geochemistry Russian Academy of Sciences (IGEM RAS), Staromonetny Pereulok, 35, Moscow, Russia, Lexin A. B. ,   Institute of Geology of Ore Deposits, Petrography, Mineralogy and Geochemistry Russian Academy of Sciences (IGEM RAS), Staromonetny Pereulok, 35, Moscow, Russia
Published: December 2021

The article deals with the creation of an information and analytical platform for assessing external causes of technogenic (man-made) accidents and for improving methods of their predication and prevention on the territories of long-term geological, mining, and engineering activities on the Southeastern (SE) Transbaikal region example — one of the key areas for mining and extraction of the strategic raw minerals in Russia. 3D modeling of active geological structures and hazardous seismogeodynamic processes on GIS-based technologies is a key instrument for forecasting dangerous natural and technogenic events and risk reduction of their occurrence. A matter of minimizing consequences of natural and technogenic disasters for such facilities of increased technological and environmental hazards as minefields, radiochemical facilities, sites for spent nuclear material disposal, dams, gas and oil pipelines, etc. has become essential. It is necessary to assess modern geodynamic territory’s activity on a unified geoinformation platform applying the newest integrated geological-geophysical researches’ methods for these objects, to select seismically active fault-fracture zones, to determine the rate and direction of surface displacement, to establish patterns of subsoil stressed-strained state natural component influence on behavior of local technogenic processes. Taking into account the specificities of geotectonic structure of mining territories, the structure of monitoring seismogeodynamic processes network on multifunctional geodynamic test sites should be developed. Observations made on test sites form the information basis for forecasting of lithosphere condition, taking decisions on rational subsurface management and providing ecological safety of the territory.
Más allá del mensaje de salvación
Authors: Gascón Gutiérrez Jordi
Published: December 2021

The paper compares two periods in the history of a Quechua community (Amantaní Island, Titicaca Lake, Perú). They were moments of social conflict, in which the Seventh-day Adventist Church played a significant role. At each moment, different indigenous sectors, with different interests, and political and economic objectives, showed greater predisposition to religious change. This demonstrates the strategic nature of the conversion. But religious change was not necessarily a conscious strategy. The islanders do not notice the relationship between interests and the option of faith. Bourdieu's constructivist theory allows us to understand how the conversion coherently fits the objectives of each social group, even if it is not the result of planning. The research is based on three qualitative sources: participant observation, in-depth interviews, and public and private archives.
Apoyo Socio-familiar y Afrontamiento al Estrés asociado al Bienestar Psicológico en Personas con Obesidad
Authors: González Sotomayor Roxana , Ruíz Martínez Ana Olivia , González Arratia López Fuentes Norma Ivonne , Oudhof-van Barneveld Hans , Vázquez Arévalo Rosalía
Published: December 2021

La obesidad es un problema a nivel mundial que ha ido en aumento, existen evidencias que muestran que el bienestar psicológico es un factor asociado a la efectividad de la prevención y el tratamiento de la obesidad, por lo que resulta importante evaluar otros factores psicológicos como el afrontamiento al estrés y el apoyo social que podrían predecir el bienestar de esta población. El objetivo fue analizar el impacto de las estrategias de afrontamiento al estrés y el apoyo socio-familiar sobre el bienestar psicológico en personas con obesidad. Se aplicaron los instrumentos: Cuestionario de Afrontamiento al Estrés, Escala de Apoyo Social Familiar y de Amigos y Escala de Bienestar Psicológico de Ryff, a 286 personas con obesidad. Los resultados indican que las estrategias de afrontamiento de focalización en la solución del problema y autofocalización negativa, así como, el apoyo familiar, impactan en el Bienestar Psicológico de las personas con obesidad. Estos resultados señalan el efecto predictivo de variables individuales y familiares sobre el bienestar de las personas con obesidad, que podrían complementar los programas de intervención.
Rasgos de Personalidad y Depresión, Predictores de Ansiedad Rasgo-Estado en Madres
Authors: García Méndez Mirna , Méndez Sánchez María Del Pilar , Peñaloza Gómez Rafael , Rivera Aragón Sofía
Published: December 2021

La Ansiedad Rasgo (A-R) y Ansiedad-Estado (A- E), se relaciona con los rasgos de personalidad (Neuroticismo, Extraversión, Apertura a la Experiencia, Amabilidad, Responsabilidad) y con la depresión, afectando la dinámica de las familias biparentales y monoparentales. El presente estudio tuvo como objetivo analizar si los rasgos de personalidad y la depresión predicen la A-R y A-E en madres biparentales (casadas y en unión libre) y monoparentales (solteras, separadas divorciadas). Participaron 836 madres de la ciudad de México con un rango de edad de 20-55 años (M = 40.2, DE = 7) que respondieron de manera voluntaria tres instrumentos. Se llevó a cabo una correlación de Pearson y regresiones jerárquicas. Los resultados indican que los rasgos de personalidad y la depresión predicen la A-R y A-E. El Neuroticismo y la depresión son predictores negativos, que favorecen la A-R y A-E en madres biparentales y monoparentales. La Extraversión, Apertura a la Experiencia, Amabilidad y Responsabilidad fueron predictores que tienden a disminuirla. Se observó una tendencia de valores predictivos de Neuroticismo y depresión más altos en las madres divorciadas y separadas lo que sugiere que ellas son más vulnerables a presentar niveles más altos de A-R y A-E en detrimento de su salud mental.
A Methodological Study to Analyze and Design the Car Chassis
Authors: Chittaliya Satishkumar
Published: December 2021

Abstract: The car's chassis is also called a structure that locates and mounts all the vehicle's components. It also creates a secure environment for the occupants. The chassis will provide torsional and flexural rigidity to the vehicle that makes the chassis one of the most crucial elements of the vehicle. Therefore, the front impact, rear impact, side impact, front torsional, rear torsional, vertical bending, lateral bending analyses were performed. The contribution of chassis is not limited to supporting the vehicle’s component, but it extends to providing better performance and aesthetics. Therefore, the design of the car chassis must be done accordingly. The current paper deals with the study of the design and analysis of the race car. The deformation, stress, and Factor of safety were considered as the evaluation parameters which were obtained by Finite Element Analysis (FEA) in Ansys software. To design the chassis, the SolidWorks software was utilized. Keywords: Car Chassis, Design, FEA, Material Comparison.
FLÜT ÇALIŞMA TEKNİKLERİ VE KİŞİSEL ÇALIŞMA YÖNTEMLERİNİN GELİŞTİRİLMESİ
Authors: TURGAY Hakan Halit
Published: December 2021

İnsanoğlu sürekli kendini geliştiren bir canlı olarak yaptığı tüm işleri en iyi hale getirmek için durmaksızın çabalamaktadır. Tüm insanlık tarihi göz önüne alındığında, insanoğlunun kendini etkin bir şekilde geliştirebilmesi bilgiye ulaşmak ile başlamıştır. Bireyin gelişimi ise, kendi yeteneklerini keşfedip yaptığı işi en iyi şekilde yapmanın yollarını aramakla başlamıştır. Tüm bunların sonucunda en değerli olgu kuşkusuz öğrenmek ve çalışmak olmuştur. Ancak her bireyin algısı ve uygulama becerileri farklılıklar gösterir. Buna göre her bireyin farklı bir çalışma ve öğrenme öngörüsü olmalıdır. Bir enstrümanı iyi çalmak isteyen her bireyin öncelikle yoğun bir çalışma rutini edinmesi gerekmektedir. Ancak bilgi ve farkındalık ile yönetilmeyen kişisel çalışmalar yoğun vakit kaybına neden olacak ve olgunlaşma sürecini uzatacaktır. Çözüm odaklı çalışmanın esasları için gereken yaratıcı çalışmanın çerçevesinde amaç; tümevarım ve tümdengelim yöntemleri ile farkındalığı arttırıp, daha rafine bir bakış açısıyla kişiselleştirilmiş çalışma sistemine ulaşmaktır. Bu makalede kabul görmüş geleneksel çalışma yöntemleri incelenmiş ve bu çalışmaların ışığında her bireyin kendi sorunlarına yönelik akılcı çalışma becerileri oluşturmasına ışık tutmak hedeflenmiştir.
The predictive power of MRI criteria in the diagnosis of immune reconstitution inflammatory syndrome by the comparison of classification using the decision tree method and ROC analysis
Authors: Bakulina E. G. , Kataeva G. V. , Trofimova T. N.
Published: December 2021

Introduction. Immune reconstitution inflammatory syndrome involving the central nervous system (CNS-IRIS) is a dangerous complication in HIV-infected patients on antiretroviral therapy (ART). The radiologic features of this syndrome have been little studied and are presented in isolated works. The diagnosis is difficult because there are no generally accepted criteria for IRIS. Our study is devoted to radiology of IRIS. Based on the results of brain MRI, together with clinical and laboratory data, MRI criteria for IRIS were formulated.Purpose and goals. To determine the prognostic value of MRI signs of CNS-IRIS using in a cohort of HIV-positive patients with neurological symptoms.Materials and methods. The analysis includes data from 68 HIV-infected patients who underwent brain MRI. In 14 of them were diagnosed IRIS with involvement of the central nervous system. To determine the diagnostic efficiency of the formulated MRI criteria, the STATISTICA program was used, decision trees were built, and a ROC analysis was performed.Results. Five decision tree models were built with different predictive values. The models took into account the categorical predictors (MRI criteria) in different order and quantity. The best performance has model #5, which can be considered a clinically useful predictive model.Conclusion. Brain MRI is an essential diagnostic step in HIV-infected patients on ART. It is necessary to expand the indications and conditions for radiological studies of the brain in patients with suspected immune reconstitution inflammatory syndrome.