bluuebunny/crossref_metadata_2025 huggingface dataset:
DToL Taxon-specific Standard Operating Procedures for the Plant Working Group v1
Authors: L Forrest Laura , Hart Michelle
Published: December 2023

This Standard Operating Procedure (SOP) collection contains guidance on how to process the various plant taxa within the scope of the Darwin Tree of Life (DToL) project. The guidance specifically refers to the tissue samples needed for DNA barcoding (which takes place at the Royal Botanic Garden Edinburgh (RBGE)) and outlines the flash frozen plant tissues required for whole genome sequencing (WGS), which takes place at the Wellcome Sanger Institute . Every specimen is submitted for DNA barcoding first before potentially being sent to the Wellcome Sanger Institute.
Preparation of cells for live-cell imaging of a FOXO-based AKT kinase translocation reporter by widefield microscopy v1
Authors: R Madsen Ralitsa
Published: December 2023

This protocol provides detailed instructions for imaging of cells with stable expression of a kinase translocation reporter, alongside a nuclear marker for segmentation. We have used this approach to measure the nuclear-cytoplasmic shuttling of a FOXO-based AKT reporter in both HeLa cells and human induced pluripotent stem cells (iPSCs). Note that we culture our cells without antibiotics except during live-cell imaging as indicated. For subsequent data analysis, please refer to the pipeline provided on the Open Science Framework under doi: 10.17605/OSF.IO/4F69N.
Mouse Brain Tissue Collection and Analysis v1
Authors: Edwards Robert
Published: December 2023

This protocol describes the dissection and collection of coronal sections of the striatum and midbrain from a mouse brain. The tissue can be used in a number of applications and here we describe two: the measurement catecholamine levels using high-performance liquid chromatography (aided by a neurochemistry core) and the distribution of the vesicular monoamine transporter (VMAT2) using a radioligand binding assay.
Collections Standard Operating Protocol, Plant group: Vascular Plants v1
Authors: L Forrest Laura , Bell David , not provided Mruhsam , Hart Michelle
Published: December 2023

This is part of the collection "DToL Taxon-specific Standard Operating Procedure (SOP) for the Plant Working Group". The SOP collection contains guidance on how to process the various land plant taxa within the scope of the Darwin Tree of Life project. The guidance specifically refers to the tissue samples needed for DNA barcoding (which takes place at the Royal Botanic Garden (RBGE)) and outlines the flash frozen tissues required for whole genome sequencing (WGS), which takes place at the Wellcome Sanger Institute . Every specimen is submitted for DNA barcoding first before potentially being sent to the Wellcome Sanger institute. This Sample Collection SOP outlines the collection of plant samples for the Darwin Tree of Life project. DToL aims to generate high quality genome sequences from these samples. To achieve this goal the DToL Genome Acquisition Labs (GALs) must access a sufficient quantity of healthy living material, preserve it in a manner that conserves its DNA quality, and supply it to the appointed sequencing facility. Material must also be available and appropriately preserved for DNA barcoding, flow cytometry and herbarium vouchers. In some instances, material for RNA extraction is also required. It is the responsibility of the GALs to also link accurate and information-rich metadata to all collections. Sample collection for genome sequencing Plant genome sequencing is carried out at the Sanger Institute; there is a cold chain from sample collection through to it arriving in the Sanger laboratories. Sample collection for DNA barcoding Plant DNA barcoding for DToL is carried out at the Royal Botanic Garden, Edinburgh (RBGE). Sample collection for genome size estimation Genome size estimation is carried out at RBG Kew. Herbarium voucher collection Where possible, the collection of voucher material is at the time of genome sampling in the field. Further preparation of the herbarium specimen can be carried out at a Genome Acquisition Lab. Definition: Tracheophyta (vascular plants) Including: Polypodiophyta, Pinophyta, Magnoliophyta Excluding:
Live Imaging of Primary Mouse Neuron Cultures v1
Authors: Edwards Robert
Published: December 2023

This protocol describes live imaging of primary neuron cultures. Included are methods for preparing hippocampal or dopamine neuronal cultures from neonatal mouse brain tissue. The imaging described involves labeling of dopamine neurons with a fluorescent DAT ligand and using virally encoded pHlourin sensors to measure vesicular release of neurotransmitter as the neurons are electrically stimulated. This technique was used in Jain et al., 2023 to compare vesicular release in neurons between various transgenic knockout mouse lines.
«El solo recurso que queda a estos pobres ciegos»
Authors: Llinares Planells Alejandro
Published: December 2023

El presente trabajo versa sobre los testamentos de ajusticiados en la literatura popular impresa española, un subgénero de literatura de patíbulo poco conocido hasta la fecha. Analizaremos diez testamentos estampados entre el siglo XVI y mediados del siglo XIX, cruzando fuentes periodísticas y de archivo, para, de este modo, poder indagar en sus posibles usos, divulgación/venta, composición y recepción.
Discordant TFT in Lupus Nephritis Patients: A Case Report and Comprehensive Literature Review
Authors:   Department of Pathology, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Published: December 2023

The thyroid function test (TFT) is usually easy to interpret, but only if the clinical assessment, thyroid-stimulating hormone (TSH), and free-T4 (fT4) levels are consistent with each other. However, there are cases where TFT results are inconsistent, which may be due to assay interference. In this regard, we presented a case study of a patient with discordant TFT results which was likely caused by assay interference. A 43-year-old woman with underlying lupus nephritis for 20 years presented with painless anterior neck swelling over three years duration. Clinically, she was euthyroid without any symptoms of thyroid gland compression. A series of TFT was requested to rule out hyperthyroidism, showing low normal fT4 ranging between 9.83 - 12.76 pmol/L (9 - 19.05 pmol/L) with suppressed TSH of 0.05 - 0.18 μIU/ml (0.35 - 4.94 μIU/ml), biochemically consistent with subclinical hyperthyroidism. The reflex free-triiodothyronine (fT3) test was normal at 3.85 pmol/L (2.63-5.7pmol/L) with negative anti-thyroglobulin and anti-thyroperoxidase antibodies. A neck ultrasound revealed four insignificant thyroid nodules. No hyperthyroid treatment was commenced except prolonged steroid therapy and azathioprine for the underlying autoimmune disease. An initial clinical assumption was made that the TFT result might be possibly due to assay interference. The TFT results led to several differential diagnoses: subclinical hyperthyroidism, nonthyroidal illness (NTI), recent hyperthyroid treatment, drug, or assay interference (biotin, anti streptavidin antibodies, macro-TSH, anti-ruthenium antibodies, thyroid hormone autoantibodies, and heterophilic antibodies) . The patient’s normal fT3 ruled out NTI. Furthermore, the patient was not on any anti-hyperthyroid medications to explain it as the cause. Chronic glucocorticoid therapy reduces TSH secretion and inhibits thyroxine-binding globulin (TBG) synthesis, but steroids rarely result in thyroid dysfunction. Our laboratory method was a non-biotinylated chemiluminescent assay using the Abbott Allinity system, devoid of biotin-streptavidin interaction. The patient's results disagreed with other assay interference (macro-TSH, anti-ruthenium antibodies, thyroid hormone autoantibodies, and heterophilic antibodies), as they resulted in falsely high TSH and fT4 in most literature. Nonetheless, sample treatment with heterophile binding receptors can help to confirm further whether the patient's TFTs were consistent with true subclinical hyperthyroidism.
The Construction of Definitions Through Padovan’s Combinatorial Model: An Investigation With Didactic Engineering in an Initial Education Course for Mathematics Teachers
Authors: Vieira Renata Passos Machado , Alves Francisco Regis Vieira , Catarino Paula Maria Machado Cruz
Published: December 2023

Background: Given the oversight of specific topics in the history of mathematics books, this research was motivated by the extensive coverage of the Fibonacci sequence. In addition, the existence of the Padovan sequence, which is considered a Fibonacci cousin, stands out. Objectives: Investigating the Padovan sequence, building its definition through a combinatorial model using manipulative materials based on the theory of didactical situations in the initial mathematics teacher education course context. Design: The research methodological design follows didactic engineering, and a didactic teaching situation is created to investigate the Padovan sequence. Thus, manipulative material was developed to facilitate the teaching process and the construction of the sequence definition. Settings and participants: The interventions were done in the mathematics degree course of a higher education institution in Fortaleza. Five students enrolled in the component of History of Mathematics participated in the study. Data collection and analysis: Data were collected during classes, recorded through photos and audio recordings, based on didactic engineering and the theory of didactical situations. Results: The most relevant result of this study is constructing the definition of the Padovan sequence through the manipulative material. Conclusions: We concluded that the research allowed an investigation of the Padovan sequence, enabling the visualisation of its terms and their integration with other mathematical contents, contributing to teaching these numbers.
Shwannoma of the stomach and synchronous cancer of the transverse colon: a clinical case report
Authors: Baychorov A. B. , Danilov M. A. , Karnaukhov N. C. , Abdulatipova Z. M. , Leontiev A. V. , Sahakyan G. G.
Published: December 2023

With an increase in the frequency of publication of clinical observations with synchronous neoplasms of different histological types, experience is accumulating in the diagnosis and treatment of this cohort of patients. new clinical guidelines and strategies for the treatment of patients with primary multiple neoplasms of the gastrointestinal tract are being developed. A significant number of identified cases of the development of minimally invasive laparoscopic and robotic surgical interventions for primary multiple neoplasms of the gastrointestinal tract, as well as an increasing number of studies demonstrating the integrity and safety of performing minimally invasive endoscopic intraluminal aids in small mesenchymal tumors. The clinical observation presents the data of patient 82 years old with benign schwannoma and adenocarcinoma of the transverse colon.
Targeted approach to assessing the impact of living conditions and social factors of the habitat on the medico-demographic status of rural territories in the Arctic zone of the Russian Federation
Authors: Dudarev Alexey A. , Dozhdikov Alexey V.
Published: December 2023

BACKGROUND:According to the Federal Law “On Sanitary-Epidemiological Well-being of the Population” the “environmental factors that have or may have an impact on humans and on health of future generations” along with chemical, physical and biological factors, also include “social factors". Within framework of section “State of Public Health in Connection with the State of Natural Environment and Living Conditions” of the system of state sanitary and epidemiological regulation, a significant number of normative and methodological documents have been approved aimed at assessing the impact of chemical, physical and biological environmental factors on population health, while not a single document has been developed concerning “social factors of habitat” or “living conditions”. In the “Strategy for the Development of the Arctic Zone of the Russian Federation (AZRF) until 2035” , the “main dangers, challenges and threats that form risks for development of AZRF” include clear signs of deterioration in medico-demographic situation, where, along with migration outflow, reduction of population number, high mortality rate, “lag behind all-Russian values of indicators characterizing quality of life”, poor state of social, housing, communal, transport infrastructure were noted.
OBJECTIVES:development of the concept of “living conditions” as a set of “social factors of habitat” formed by “social infrastructure” of a settlement; development of conceptual model of determinants of human health, indicating place of living conditions (social infrastructure) in the frame of habitat; scientific substantiation of concept of “harmful effects of social factors of habitat”; development of targeted approach to assessing the impact of living conditions on medico-demographic status of rural areas of AZRF using scoring system for assessing living conditions, which makes it possible to rank individual villages according to the value of infrastructure indices and the integral index of living conditions (IILC).
PRACTICAL SIGNIFICANCE:Implementation in practice of the proposed targeted methodological approach will make it possible to scientifically substantiate the need to take differentiated measures (managerial decisions) in relation to the identified “risk territorie”, “risk group”, and “risk pathologies”, aimed at improving living conditions, preserving public health, ensuring sanitary-epidemiological well-being, reducing the intensity of negative trends in demographic processes in the regions of AZRF.
Dental health in the adult population of Arkhangelsk: а study protocol
Authors: Simakova Anna A. , Kudryavtsev Alexander V. , Gorbatova Maria A. , Drachev Sergei N. , Yushmanova Tatiana N. , Podrezova Anastasia V. , Grjibovski Andrej M. , Gorbatova Lyubov N.
Published: December 2023

BACKGROUND: The Arkhangelsk region is characterized by a high prevalence and intensity of dental diseases among adults, but most of the studies were either hospital-based or used small samples with questionable representativeness.
AIM: This article is a protocol of an original study, the purpose of which is to assess the dental status and its association with somatic health in a representative sample of the adult population of Arkhangelsk.
MATERIAL AND METHODS: In 2022, a cross-sectional study “Prevalence of dental pathology among the population of the Arctic zone of the Russian Federation (using the example of Arkhangelsk) and associated characteristics of the microbiome of the intestine and the respiratory tract” (hereinafter referred to as the dental study) was conducted in Arkhangelsk. The dental study was a part of the study “Molecular and genetic markers of the response to coronavirus infection and changes in the human microbiota and metabolome during the COVID-19 pandemic” (hereinafter referred to as the study on the effects of COVID-19). Data collection for the study was carried out from October 3 to November 10, 2022 at the Northern State Medical University. The study involved 463 adults aged 42–76 years living in the city of Arkhangelsk, representing a random sample of the adult population who had previously taken part in the “Know Your Heart” project in 2015–2017. All participants were asked to undergo an additional dental examination. The response rate was 91.6%. The dental examination included a questionnaire, assessment of dental status as recommended by the World Health Organization (2013), assessment of oral hygiene and gum inflammation, dental aesthetic index (DAI), collection of gingival fluid, autofluorescence stomatoscopy (AFS), examination by an orthodontist with periotestometry, performing a photo protocol, conducting biometrics of plaster models. When indicated, participants were asked to undergo an in-depth diagnostic to identify orthodontic pathology, namely, teleradiography and a cone-beam computed tomography.
EXPECTED RESULTS: The proposed study using validated instruments and a representative sample has a major strength in providing unbiased assessment of the prevalence of oral health conditions in Arkhangelsk in the studied age group. Moreover, the material collected in this study has a potential to provide a unique opportunity to assess the associations between dental health and somatic health, lifestyle, microbiota, and metabolome since the data on the abovementioned characteristics were collected during the other projects and stored in a biobank.
_Understandeconstructing Data: Lessons From jAIna Onto-Epistemology
Authors: Galanos Vassilis
Published: December 2023

This is an experimental application of the Jaina seven-valued logic on the question of dataism, the problematic, chiefly Euro-US-centric, ideology for data-driven technosolutionism, in the context of higher education. Based on my own teaching experience and on this underrepresented onto-epistemological framework from India, I show the simultaneous validity of seven seemingly contradictory arguments, suggesting that this may be a practical way to escape unnecessary disputes within the field of critical data studies. These arguments focus on the interplay between different contexts where data are considered meaningful (or meaningless) and/or existentially relevant (or irrelevant).
The Global Infrastructuring of Research Data and its Risks for (Particularly Qualitative and Critical) Education Scholarship
Authors: Hartong Sigrid
Published: December 2023

This essay problematizes the so-far absence of broader critical debate on the governing dynamics around research data infrastructuring (not only) in education scholarship. More specifically, it refers to the growing role of large-scale data infrastructures as well as complexes of Research Data Management (RDM) that seek to foster ‘open’, reusable, and increasingly machine-readable (education) science. While research data infrastructuring in general, and RDM in particular, have so far been predominantly discussed from solutionist-positivist perspectives, this essay discusses the underestimated risks that lie in the governance dynamics of research data infrastructuring, including: (1) the gradual narrowing of what kind of education, but also what kind of education research become visible in and through data infrastructures (namely those that build on already dominant hierarchies in the field); (2) a gradual shift from doing research towards ‘doing data’, including a shift of political attention and research funding, as well as (3) effects of normalization, also triggered through extensive dataveillance, shareveillance, and ‘ethical monitoring’ of researchers. This particularly endangers genuinely qualitative and critical research in education.
Evolución del marketing y perspectiva de universitarios acerca de prácticas actuales
Authors: Cerino Pérez Jaquelin , Hernández Romero Gladys
Published: December 2023

La presente investigación tiene por objetivo conocer la opinión de estudiantes universitarios de la Licenciatura en Mercadotecnia, acerca de prácticas actuales que pueden realizarse dentro de esta ciencia y sus subramas. La metodología es de tipo cuantitativo con corte descriptivo, donde a partir de una encuesta con 9 enunciados con escala tipo Likert, se pudo conocer que los estudiantes opinan que la meta principal del marketing es satisfacer a los clientes, que el marketing verde compromete a las empresas a realizar cambios en favor del medio ambiente, aunque muchas podrían solo fingir que lo hacen, que el marketing digital en términos de efectividad ya supero al marketing tradicional, aunque la diferencia de recursos entre pequeñas y grandes empresas puede generar una competencia desleal y que, aunque el marketing turístico genere conciencia sobre la diversidad cultural y natural, puede promover la sobreexplotación de destinos y un deterioro al medio ambiente.
Efecto de la composición botánica de los henos y del nivel de ingestión sobre su digestibilidad y ritmo de paso a través del tracto digestivo
Authors: Dolores Carro Travieso María , López Puente Secundino , Salvador González Álvarez Jesús , Javier Ovejero Martínez Francisco
Published: December 2023

Se ha estudiado la digestibilidad y el ritmo de paso a través del tracto digestivo de dos henos -heno de alfalfa (HA) y heno de gramíneas (HG)-, administrados a dos niveles de ingestión -mantenimiento (NB) y 90% de la ingestión voluntaria (NA)-. Para determinar el ritmo de paso se usó cromo ligado a la fibra como marcador, utilizando, en cada caso, muestras del heno (molidas a un tamaño de malla de 2 mm.) que estaban consumiendo los animales. El nivel de ingestión no afectó (P > 0,05) a la digestibilidad aparente de la materia orgánica (DMO) ni a la de ningún otro componente de los henos. La digestibilidad de la pared celular (DFND) y la de sus componentes fue superior (P < 0,05) para el heno de gramíneas que para el de alfalfa, pero éste presentó una digestibilidad de la proteína bruta (DPB) más alta (P < 0,05). No existieron diferencias estadísticamente significativas (P > 0,05) en el ritmo de paso y el tiempo medio de retención total en el tracto digestivo (TMRT) de los dos henos. Por el contrario, el aumento del nivel de ingestión (NA) provocó un mayor (P > 0,05) ritmo de paso a través del retículo-rumen (K1), y una disminución (P < 0,10) del TMRT.
Cambios en el contenido en macronutrientes y en la composición en aminoácidos de sardina fresca y sardina descongelada por refrigeración o en horno microondas
Authors: María Castrillón A. , Trinidad García Arias María , Del Camino García Fernández María , E. Alvarez Pontes M.
Published: December 2023

Sardina (Clupea pilchardus) se sometió a congelación, almacenamiento en estado congelado y posterior descongelación mediante dos procesos diferentes: convencional (refrigeración) o en microondas. En sardina fresca y descongelada, se analizó el contenido en humedad, grasa, proteína y cenizas y la composición en aminoácidos de la proteína, con objeto de comparar la influencia de las dos formas de descongelación más habituales. La sardina descongelada en microondas mantuvo su contenido en proteína al mismo nivel que la sardina fresca, mientras que en la descongelada en frigorífico este nivel descendió. El contenido en cenizas disminuyó en ambos casos y el porcentaje de grasa fue mayor en la sardina descongelada en frigorífico. Respecto al contenido en aminoácidos se destaca una pérdida de cistina, histidina y lisina, tras la descongelación en ambos modos, detectandose también pérdidas en practicamente el resto de aminoácidos durante la descongelación convencional, que se retuvieron sin embargo tras la descongelación en microondas.
Cambios en las proteínas durante la maduración del chorizo
Authors: Zumalacárregui Rodríguez José María , Domínguez Fernández de Tejerina Juan Carlos
Published: December 2023

En el presente trabajo se ha estudiado la intensidad de la proteolisis y la pérdida de extractibilidad de las proteínas durante la maduración del chorizo elaborado por procedimientos artesanales e industriales. A lo largo de la maduración se observa un aumento del nitrógeno no protéico (NNP), nitrógeno a-aminoacídico y nitrógeno básico volátil total (NBVT), mientras que el nitrógeno peptídico desciende. Tanto las proteínas miofibrilares como las sarcoplásmicas sufren una pérdida de solubilidad elevada.
Producción animal y tecnología del ADN
Authors: Castro González José María , Sandoval H.
Published: December 2023

Los límites en la aplicación de la biotecnología en producción animal, parecen avanzar mas allá de lo éticamente aceptable. Las modernas técnicas de Biología Molecular, están encontrando aplicación en todas las áreas de la producción animal. Esta revisión es una visión global del potencial que ofrece la moderna biotecnología en la Producción animal, con un énfasis especial en ganado ovino y caprino.
Bone defect management with tissue-engineered constructs based on deproteinized cancellous bone: an experimental study
Authors: Anastasieva E. A. , Cherdantseva L. A. , Tolstikova T. G. , Kirilova I. A.
Published: December 2023

Background Management of bone defects with autologous bone grafting has always been the "gold standard" but it is not always possible to use it for a number of reasons. Preprocessed materials of biological and non-biological origin were developed as an alternative. A new branch of these materials is tissue-engineered constructs that fully imitate autologous bone in required volume.

Aim is to study in vivo the possibility of using deproteinized human cancellous bone tissue as a matrix for creating tissue-engineered constructs.

Methods The study was carried out on 24 NZW line rabbits, since this line has a fully characterized stromal-vascular fraction formula (SVF). The study design included 3 groups. First group (control) had surgical modeling of bone defects in the diaphysis of the contralateral femur without reconstruction; Group 2 had bone defect reconstruction using fragments of a deproteinized cancellous bone graft; group 3 underwent bone defect reconstruction using fragments of deproteinized cancellous bone matrix along with the autologous adipose tissue SVF (obtained according to ACP SVF technology). Animals were sacrificed with ether anesthesia at 2, 4 and 6 weeks after the operation and subsequent histological study followed.

Result During all periods of the study, the newly formed bone tissue volume density in the 3rd group (reconstruction with deproteinized human cancellous bone + stromal-vascular fraction) was 1.78 times higher (p < 0.001) than in the first group (bone defect without reconstruction), 1.21 times higher (p < 0.001) than in the 2nd group (reconstruction with deproteinized cancellous bone alone). The dynamics of changes in the mature bone tissue volume density was similar to those of the newly formed bone tissue.

Discussion The comparative analysis of reparative processes using a tissue engeneered construst based on deproteinized cancellous human bone with adipose tissue stromal vascular fraction revealed that the use of these bone substitute materials contributes not only to the early activation of reparative regeneration of the main structural elements of bone tissue at the site of bone defect, but also their timely differentiation.

Conclusion The use of deproteinized cancellous bone matrix combined with stromal-vascular fraction to create a tissue-engineered construct could unleash several regeneration mechanisms and accelerate the process of bone defect site repair, compared with 1st and 2nd group of study.
Aneurismal bone cyst of the medial cuneiform bone: a case report of a new surgical approach and literature review
Authors: Leonchuk S. S. , Punit T.
Published: December 2023

Introduction An aneurysmal bone cyst (ABC) is a rare, non-neoplastic, destructive, hemorrhagic, and expansile lesion accounting for 1 % of all bone tumors. ABC of the foot is very rare. Patients with foot ABC usually complain of pain and swelling of the affected area. Radiographs and MRI may be helpful in the diagnosis of ABC. No single surgical procedure has gained wide acceptance in the treatment of foot ABC.

Purpose To show new effective surgical approach in the treatment of patient with ABC of the medial cuneiform bone.

Material and methods We present the case of a 47-year-old woman with a 10-months history of pain and swelling in her right foot. Postoperative histopathological evaluation of resected tissues confirmed the diagnosis of ABC. An en bloc resection (total extraction of the remnant of the medial cuneiform bone) was performed and the defect was replaced with a fibular bone graft from the right leg. Allograft (Bio-Ost®) was placed along the autograft. Tibialis anterior tendon was attached to the fibular bone graft. We performed fixation of the foot and ankle using the Ilizarov original apparatus for prevention of bone graft instability and opportunity for early weight-bearing on the operated foot.

Results The postoperative period was uncomplicated with complete healing of the bone defect without recurrence after 12 months of observation. AOFAS score increased significantly from 34 points preoperatively to 92 at 1-year follow-up.

Discussion The optimal treatment of this lesion is still under discussion. Different treatment modalities have been described in the literature: wide resection, curettage with or without adjuvants, arterial embolization, intralesional sclerotherapy. Biological reconstruction using bone graft seems to be the best option, but fractures and nonunion are common complications of bone grafting.

Conclusion The combination of Ilizarov external fixation and bone grafting provided favorable conditions for the healing of foot bone defect due to ABC without complications, allowed mobility and early weight-bearing of the patient. Recurrence was not detected radiologically. Harvesting of the fibular bone graft did not affect the position of the foot and its movements. Our surgical approach should be considered as a treatment option in similar cases.
A research of integrated balun surrogate model accuracy dependence on modeling conditions and techniques
Authors: Stepanov V.I. , Metel A.A. , Salnikov A.S. , Bilevich D.V. , Dobush I.M. , Kalentyev A.A. , Goryainov A.Е.
Published: December 2023

Problem statement. Electromagnetic (EM) simulation is one of the main steps in the microwave monolithic integrated circuits design process. However, this approach is not used for structural and parametric synthesis. This is due to the time-consuming computation, which depends on many parameters of the simulated device. This problem applies to devices such as antennas, inductors, and transformers. Using compact models is the one of the ways to solve the time-consuming problem. However, in many cases, the analytical calculation of circuit elements in compact models is not possible due to the large number of elements, leading to a complex extraction technique. Moreover, depending on the process of the device, it is necessary to use different compact models, and for antennas, they do not exist. Using the surrogate model can be an alternative way to solve this problem. A surrogate model is a model that is comparable in accuracy to EM simulation but with lower computational time. Surrogate models can be building for any device and do not depend on their process, making this approach universal, unlike compact models. Therefore, the use of surrogate models is the most promising approach, and the development of a methodology for constructing surrogate models is an actual task. Purpose. To research surrogate modeling conditions and methods of the integrated balun, to suggest a surrogate modeling technique and synthesize integrated balun with specified requirements by suggested technique. Results. An investigation of approaches to building surrogate models was carried out. A universal technique for building a surrogate model was developed using space mapping and Kriging interpolation technique. Using the built surrogate model, the synthesis of an integrated balun was performed based on a commercial 0.25 μm GaAs pHEMT process. Practical significance. The developed technique allows us to build surrogate models for various microwave devices that require time consuming EM modeling. The obtained by suggested technique surrogate models can be used for parametric synthesis.
The current state and the mechanism of the transformation of the ESG agenda by Russian companies. Part 2.
Authors: Izmailova M. A.
Published: December 2023

Purpose:   development of a mechanism for the ESG transformation of Russian companies based on a critical assessment of the evolution and modern implementation of the ESG agenda in Russia. In the second part of the article, the author solves the problem of analyzing the compliance of the content of the Russian ESG agenda with global risks and developing a mechanism for the ESG transformation of Russian companies.

Methods: methods of theoretical analysis were applied, which made it possible to reveal the conceptual component of the ESG agenda and sustainable development; empirical analysis of the global risk landscape and the implementation of the Russian ESG agenda; a statistical method for determining priority areas for the implementation of the Russian ESG agenda; abstraction and modeling to formalize the ESG transformation mechanism/

Results: the conceptualization of the ESG agenda and sustainable development was carried out, the content basis of which harmonizes with corporate social responsibility. The mobility of the landscape of global risks with a steady trend of the prevalence of environmental and social risks is determined. The results of the implementation of the Russian ESG agenda based on the results of 2022 and the tasks for the near future are summarized. Priority directions and barriers to the implementation of the ESG agenda have been established. Proposed mechanism for ESG transformation of Russian companies.

Conclusions and Relevance: the functioning of national economies is influenced by global threats: environmental and social risks are leading in the next decade. The results of the implementation of the Russian ESG agenda indicate its adequacy to the nature of global risks. In environmental policy, attention is focused on energy saving and waste recycling technologies, in social policy - on social guarantees and support for the professional and personal development of employees, in corporate policy - on consumer surveys and selection of suppliers. Among the barriers to the implementation of the ESG agenda: financial, associated with fears of non-return of investments and high costs for the ESG agenda; methodical, manifested in the absence of uniform standards and ESG indicators; lack of external incentives and low ESG-competence of management. The low awareness of company management about ESG and how to incorporate it into business processes served as the basis for developing a mechanism for transforming a business model based on ESG principles, including an ESG transformation model, operating principles and required competencies.
Digitization of employment: the conceptual apparatus
Authors: Kamarova T. A. , Tonkikh N. V.
Published: December 2023

Purpose:  is to develop the theoretical and methodological foundations for the study of digitalization of employment based on an assessment of the depth of penetration of information and communication technologies into labor processes and clarification of the essential characteristics of the phenomenon of "digital employment".

Methods: the goal was achieved using traditional methods: desk research, structural and logical analysis, systematization and generalization of information. The empirical database was formed on the basis of sociological methods: a structured survey of the able-bodied population of the Ural Federal District and an expert survey of representatives of the business and scientific community. The scale of digitalization of employment in the region was determined by the methods of statistical analysis. When processing the results of an expert survey, the methods of semantic and SWOT analysis of content were used.

Results:  the relevance of clarifying the conceptual apparatus of digitalization of employment is problematized. Sociological assessments showed a high level of penetration of information and communication technologies (ICT) into the labor sphere (81.3%) and a variety of formats, modes and nature of employment in the digital segment of the labor market, its differences from the non-digital sector. The intensity of the use of ICT has a high variation: from less than 30% during the working day to 70–100%. IT specialists and specialists who use ICT in their work mainly work remotely or in a hybrid format (51%), while those employed using digital platforms work in the office (66.7%). In the segment of platform employment, there are difficulties with self-identification of the place of work and employment status. The essential features of the phenomenon of "digital employment" are identified and the key criteria for classifying employment as a digital type are expertly substantiated, the author's definition of the concept of "digital employment" is formulated, and an enlarged classification is proposed.

Conclusions and Relevance: the application of the author's approach can form the basis for refining the methodology for assessing the scale of digital employment and its characteristics. Digitalization of employment generates both positive and negative consequences. Research on digital employment is promising in terms of sustainability or instability of working conditions and social risks.
Regional digital transformation strategies: algorithm for updating projects and goals
Authors: Lobkova E. V. , Osadchenko E. A.
Published: December 2023

Purpose:   is to develop an approach to the procedure for updating regional strategic plans in the field of digital transformation, based on the algorithm for solving the problem of optimizing the levels of achievement of project goals in key industries of the constituent entities of the Russian Federation.

Methods:  the research was based on the documents of the regulatory framework of strategic planning in the Russian Federation and the texts of approved and updated strategies of the constituent entities of the Russian Federation in the field of digital transformation. Methods of constructing strategic maps and decomposing goals, linear programming and finding the optimal solution were used.

Results: the formulation of the linear programming problem has been detailed to find the optimal values for achieving the goals of digital transformation, taking into account the features of its field of application. The procedure for decomposing strategic goals and assigning coefficients of relationship between them is illustrated. The quantitative estimates obtained by the authors for solving the problem are presented and explained.

Conclusions and Relevance:   in the process of developing and subsequent updating of strategic plans for digital transformation, the constituent entities of the Russian Federation are guided by the recommendations of federal authorities and territorial specifics. They take into account new trends in the digital transformation of industries, achievements and limitations on the path to fundamentally different conditions for managing the region and doing business. Digital transformation is proceeding with varying degrees of intensity – there is both territorial and industry differentiation. To a large extent, the speed of transformation processes depends on the ongoing regional policy and the content of the implemented strategic digital projects. The revision of the list of projects and target indicators is due to the necessary adjustment of the goals and emphasis of the transformation process. Assessing the optimal values of industry development indicators, taking into account resource limits, serves the purpose of updating regional strategic plans in the field of digital transformation of key industries and areas.
Integral and generalized indicators of development and ensuring the national security of the country
Authors: Starovoitov V. G. , Eremin V. V. , Pobyvaev S. A. , Zolotarev E. V. , Lapenkova N. V.
Published: December 2023

Purpose:   presentation of the results of research on the development and application of methods for calculating integral and generalized indicators intended for assessing the state and making effective management decisions in the field of development and ensuring national security of Russia.

Methods:  the following methods were used in the study: methods of statistical data preparation, the method of expert assessments, the T. Saaty method, the method of the Center for political conjuncture, the method of linear convolution.

Results: the article provides an overview of approaches to managing development and ensuring national security in Russia and a number of foreign countries using various indicators. The authors have developed a methodology for forming integral and generalized indicators of development and ensuring the national security of Russia. The calculation of generalized indicators of the state of economic security in the field of civil air transportation and aircraft manufacturing in Russia in 2021-2022 is presented. The authors proposed a mechanism for analytical interpretation of the influence of changes in general and specific indicators on the transformation of the integral indicator.

Сonclusions and Relevance:   when studying complex socio-economic phenomena, there is a need to use generalized and integral assessments. This is due to the large amount of information that needs to be analyzed, summarized and structured. Generalized and integral indicators are necessary for forecasting and planning development while ensuring the national security of the country. Such indicators make it possible to quickly and efficiently assess current socio-economic processes, respond in a timely manner and take measures to solve emerging problems. In the article, the authors propose to analyze the dynamics of generalized and integral indicators characterizing the development and ensuring the national security of the country, which makes it possible to identify potential threats and risks and timely take measures to minimize them.
Human capital quality and its impact on economic growth of Russian regions
Authors: Mabiala G. , Linskiy D. V. , Amirova E. F. , Afonasova M. A. , Bogomolova A. V.
Published: December 2023

Purpose:  is to empirically substantiate the impact of human capital quality on the economic growth of the regions of Russia on the basis of theoretical and methodological generalization of its main aspects.

Methods:along with traditional methods, specific methods were used, such as content analysis, methods of expert assessments and comparative analysis, and the calculation and graphic technique of Xiang-Yeaple, which allowed to identify the state of human capital quality, as well as establish its optimal structure suitable for dynamic economic development.

Results:the cognitive and non-cognitive parameters of human potential are established as a realistic factor in the dynamics of gross regional product that determines the future pace of economic development. A comparative analysis of the labor demand and supply elasticity coefficients has revealed the degree of impact of its quality in ensuring the corresponding trends of economic growth. It was proven that significant investments in human capital and high levels of its development represent only a factor of ensuring economic growth and don’t guarantee its achievement. Recommendations for ensuring the development of labor potential as determinant of economic development, the growth rates of which largely depends on the human capital quality.

Сonclusions and Relevance:   the Russian economy should focus on the formation and development of high-quality human capital through talent-fueled innovation by reforming the existing education system and assessing scientific potential in order to optimize the labor and branch structure suitable for high-quality economic growth. Human capital should be structured considering the parameters of its quality, the level of available labor potential, and the types of activities that require advanced knowledge for systemic economic growth.
Analysis of rating methods for assessing the scientific and technological development of the Federal districts of the Russian Federation
Authors: Egorov N. E. , Kovrov G. S.
Published: December 2023

Purpose:  the article presents an analysis of the rating methods for the possibility of their use to assess the level of scientific and technological development of the Federal districts of the Russian Federation.

Methods:the methods of comparative analysis, the method of arithmetic averages, the method of median ranks, the method of rating and the method of correlation analysis were used in the work. The research is based on materials and data from the ratings of scientific and technological development of regions - the Index of Scientific and Technological Development of the rating agency RIA Rating, the National Rating of Scientific and Technological Development of subjects of the Russian Federation of the Ministry of Education and Science of the Russian Federation and the Rating of Scientific and technological development of subjects of the Russian Federation of the Institute of Economics of the Russian Academy of Sciences.

Results:the authors propose the algorithm for researching the scientific and technical development of regions, according to which, first of all, the relevant methodological approaches and assessment methods presented in the scientific literature are analyzed. Based on the results of the analysis of rating methods and author's developments in this area, three ratings of scientific and technological development of the regions of the Russian Federation, carried out by different organizations, were selected for study. The comparative analysis of the selected ratings has been carried out. Based on their materials, an assessment of the current state of scientific and technological development of the Federal districts of the country was carried out. The calculation and assessment of scientific and technological development of the Federal districts of the Russian Federation were carried out using the method of arithmetic averages and the method of median ranks. The correlation between the results of the ratings under consideration is determined.

Conclusions and Relevance:  according to the authors, the selected ratings can be used as adequate methods for assessing the level of scientific and technological development of the Federal districts of the Russian Federation. The proposed research algorithm allows us to demonstrate the correlation between the results of scientific and technological development ratings. The authors see the prospects for applying the results of this study in improving the tools for monitoring the scientific and technological development of regions and Federal districts of the Russian Federation.
Rationale of a comparative analytical study on matrix metalloproteinases associated with genital prolapse in Congolese women from the town of Kananga in the Democratic Republic of Congo: research protocol
Authors: Kayembe Antoine Tshimbundu , Muela Andy Mbangama , Tozin Rahma Raschid
Published: December 2023

Background: Genital prolapse is a pelvic static disorder associated with urinary, digestive and genital disorders which bother the patient. The fear of these discomforts has pushed many Western countries to adopt beneficial preventive measures for women at risk, notably the administration of estrogen-progestogens and the prevention of obstetric trauma. These two preventive factors play an inhibitory role on matrix metalloproteinases degrading the collagens which ensure ligament firmness. This link between matrix metalloproteinases and collagen is implicated by many researchers in the occurrence of genital prolapse. Objectives are to determine the epidemiological and clinical profile of genital prolapse, to identify the non-molecular factors associated with it, to determine the level of matrix metalloproteinases-1, -2 and -9 in non-prolapsed and prolapsed pelvic tissues, and to identify the types MMPs associated with genital prolapse in Congolese women from the town of Kananga in central Kasai in DR Congo.
Methods: We designed a protocol for a comparative analytical study focusing on the epidemiology and the level of matrix metalloproteinases in non-prolapsed and prolapsed pelvic tissues in the Bon-Berger and Saint Georges hospitals in the city of Kananga. Women over 40 years of age and of any parity suffering from genital prolapse and other benign gynecological pathologies requiring hysterectomy will be included in the study according to non-probabilistic convenience sampling.
Conclusions: This study will evaluate the level of matrix metalloproteinases-1, -2 and -9 in prolapsed tissues and identify the type of matrix metalloproteinases most associated with genital prolapse in our setting.