bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolution and Development of Extra-Ocular Nerves and Muscles in Vertebrates
Authors: Fritzsch Bernd
Published: June 2023

Extraocular eye muscles (EOMs) are innervated by axons of three ocular motor nuclei, the oculomotor (CNIII), trochlear (CNIV), and abducens (CNVI) neurons. The purpose of this review is to analyze the origin of ocular motor neurons, define the pattern of innervation of nerve fibers that project to the EOMs, pro-vide an overview of vestibular pathway inputs to ocular motor nuclei, and describe congenital disorders that alter the development of ocular motor neurons. Oculomotor neurons originate in the midbrain and innervate the ipsilateral orbit, except for the superior rectus and the levator palpebrae which are contra-laterally innervated. Trochlear motor neurons originate at the midbrain-hindbrain junction and innervate the contralateral superior oblique muscle. Abducens motor neurons originate variously in the rhombomeres r4-6 and innervate the posterior (or lateral) rectus muscle and innervate the retractor bulbi. Genes allow yielding a distinction between special somatic (CNIII, IV) and somatic (CNVI) ocular motor neurons. The ocular motor neurons are innervating somites, which receive innervates vestibular nuclei that connects with the brainstem motor neurons. Development of ocular motor neurons and their axonal projections to the EOMs may be derailed by various genetic causes, resulting in the congenital cranial dysinnervation disorders.
On Possible Minimal Length Deformation of Metric Tensor and Affine Connection
Authors: Farouk Fady Tarek , Tawfik Abdel Nasser , Tarabia Fawsy Salah , Maher Muhammad
Published: June 2023

When the minimal length approach emerging from noncommutative Heisenberg
algebra, generalized uncertainty principle (GUP), and thereby integrating gravitational fields to this fundamental theory of quantum mechanics (QM) is thoughtfully
extended to Einstein field equations, the possible deformation of the metric tensor could be suggested. This is a complementary term combining the effects of QM and general relativity (GR) and comprising noncommutative algebra together with maximal spacelike four–acceleration. This deformation compiles with GR as curvature in relativistic eight–dimensional spacetime tangent bundle, generalization of Riemannian spacetime, is the recipe applied to derive the deformed metric tensor. This dictates how the affine connection on Riemannian manifold is straightforwardly deformed. We have discussed the symmetric property of deformed metric tensor and affine connection. Also, we have evaluated the dependence of a parallel transported tangent vector on the spacelike four–acceleration given in units of L, where L = rℏcG3 is a universal constant, c is speed of light, and ℏ is Planck constant, and G is Newton’s gravitational constant.
Psychological Impacts of COVID-19 and Its Associated Factors Among People Living in Abha City, Saudi Arabia
Authors: Asiri Ebtehal Jaber , Dawria Adam , Narapureddy Bayapa Reddy , Reddy Lingala Kalyan Viswanath , Zahrani Yousef , Mugaiahgari Bharat Kumar Mamilla , Mohieldin Ali , Khan Mohammad Suhail , Muzammil Khursheed , Altijani Abdelrhman Ahmed Galaleldin
Published: June 2023

Background: The novel coronavirus (COVID-19) infection is primarily transmitted through respiratory droplets from an infected person and contact with tainted surfaces or items. Social distancing became the primary measure of preventing the spread of COVID-19, with the principal aim being to reduce the probability of contact with an already infected person. Social distancing can be distressing, as it is against the community's way of life. Saudi Arabia imposed a curfew and suspended all religious, entertainment, sporting, and mass congregations. The daily updates on COVID-19 infection and mortality are upsetting and further, aggravate depression and anxiety. With this background, this study was planned with the following objectives. To determine the sociodemographic profile of the study participants, to find the prevalence of psychological morbidity, and to measure the association between the sociodemographic details, COVID-19 associated factors, and psychological effects among Abha citizens during the COVID-19 pandemic. Methodology: A descriptive cross-sectional community-based study was conducted in the Abha city population from August 2021 to July 22. This study followed snowball sampling, the data was collected using an online Google form the link was shared in WhatsApp groups and through emails to contacts, asking friends to share it with their friends, until reaching the adequate sample size the responses were accepted. Results: A total of 530 participated, and their age ranged from 19 -70 years. Many of the participants (34.5%, n=183) belonged to 36-45 years old. Most of the responders were 69.8% married and Females (69.2%, n=367). Half of the participants had been quarantined (49.6%), and 51.5% were scared from fear of COVID-19. 64.8% of the participants had depression; 14.2%, 20.8%, 13.6%, and 16.2% had mild, moderate, severe, and extremely severe depression, respectively. Around 58.2% of participants suffered from anxiety; 5.8% experienced mild anxiety, 21.7% moderate anxiety, and 30.7% severe anxiety. The proportion of stress among the participants was 45.0%; 10.8% had mild stress, 9.4% had moderate stress, and 24.5% had severe to extremely severe stress. Conclusions: COVID-19 poses mental health problems among individuals and communities. There is a need to find the more susceptible individuals for mental health issues or other psychological disorders. Mental health and psychological problems can be resolved with health education, counseling, and appropriate interventions to curb the negative health impacts of COVID-19.
A review on behavior and fatigue performance of orthotropic Steel-UHPC Composite Deck
Authors: Zhu Zhiwen , Zhu Ruixu , Xiang Ze
Published: June 2023

Although the Orthotropic steel decks (OSDs) have been widely used in the construction of long-span bridges, there are frequently reported fatigue cracks after years of operation, and the bridge deck overlay also presents severe damage due to OSD crack-induced stiffness reduction. The ultra-high performance concrete (UHPC), recognized as the most innovative cementitious composites and the next generation of high-performance materials, shows high strength, ductility, toughness and well performance on durability. After its first application to the OSD bridge in early 2000s, the orthotropic Steel-UHPC composite deck has been comprehensively studied worldwide. This review will summarize some important studies and findings on behavior and fatigue performance of orthotropic steel-UHPC composite deck. The existing studies and engineering application indicate that such deck system presents good bending behavior and high fatigue performance. The failure mode of shear studs in UHPC layer is dominated by shear fractures. The cracking of UHPC layer shall consider the superposition effect of stress from both the whole bridge structure and local decks. While some reasonable structural details in the traditional OSD may not work for the orthotropic steel-UHPC composite deck. It is recommended to evaluate the stress behavior and structural parameters, as well as fatigue life by conducting the field test under in-service traffic conditions.
Hepatitis E Virus Infections
Authors: Songtanin Busara , Molehin Adebayo J. , Brittan Kevin , Manatsathit Wuttiporn , Nugent Kenneth
Published: June 2023

According to the World Health Organization, approximately 20 million people worldwide are infected annually with the hepatitis E virus (HEV). There are 4 main genotypes of HEV. Genotype 1 and genotype 2 are common in developing countries and are transmitted by contaminated water from a fecal-oral route. Genotype 3 and genotype 4 are common in developed countries and can lead to occasional transmission to humans by undercooked meat. Hepatitis E virus 1 and HEV3 can lead to fulminant hepatitis, and HEV3 can lead to chronic hepatitis and cirrhosis in immunocompromised patients. The majority of patients with HEV infection are asymptomatic and usually have spontaneous viral clearance without treatment. However, infection in immunocompromised individuals can lead to chronic HEV infection. Both acute and chronic HEV infections can have extrahepatic manifestations. No specific treatment is required for acute HEV infection, no treatment has been approved in chronic infection and no HEV vaccine has been approved by the (United States) Food and Drug Administration. This review focuses on the molecular virology (HEV life cycle, genotypes, model systems, zoonosis), pathogenesis, clinical manifestation, and treatment of chronic HEV infection, especially in immunocompromised patients, to provide clinicians a better understanding of the global distribution of these infections and the significant effect they can have on immunocompromised patients.
Physiological Calcium Phosphate Management in Two Biofluids
Authors: Nelson Deanna
Published: June 2023

Management of calcium and phosphate in biofluids is key to maintaining physiological mineral homeostasis (i.e., appropriate mineralization of hard tissues and an absence of mineral deposition in soft tissues). This review describes and contrasts the ways vertebrates manage calcium phosphate in two biological fluids (breast milk and serum) and illustrates the benefits of mineral sequestration by proteins. In milk, phosphoprotein-sequestered calcium magnesium phosphates provide nutritional support, whereas in serum, protein-sequestered calcium phosphates control transport and delivery of calcium and phosphate to tissues for biological function or excretion. In addition, subsets of sequestered phosphates in serum have been identified as culprits underlying ectopic deposition of calcium phosphates and toxicity.
A Ketogenic Diet in Combination With Gemcitabine Mitigates Pancreatic Cancer Associated Cachexia in Male and Female KPC Mice
Authors: Cortez Natalia E , Pathak Suraj , Rodriguez Lanzi Cecilia , Hong Brian , Sule Rasheed O , Crone Ryman , Wang Fangyi , Chen Shuai , Gomes Aldrin , Baar Keith , Mackenzie Gerardo Guillermo
Published: June 2023

Cancer associated cachexia (CAC) is a critical contributor to pancreatic ductal adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new strategies to mitigate PDAC-associated cachexia; and the exploration of dietary interventions is a critical component. We previously observed that a ketogenic diet (KD) combined with gemcitabine enhances overall survival in the autochthonous LSL-KrasG12D/+; LSL-Trp53 R172H/+; Pdx1-Cre (KPC) mouse model. In this study, we investigated the effect and cellular mechanisms of a KD in combination with gemcitabine on the maintenance of skeletal muscle mass in KPC mice. For this purpose, male and female pancreatic tumor-bearing KPC mice were allocated to a control diet (CD), a KD, a CD + gemcitabine (CG), or a KD + gemcitabine (KG) group. We observed that a KD or a KG mitigated muscle strength decline over time and presented higher gastrocnemius weights compared CD-fed mice. Mechanistically, we observed sex-dependent effects of KG treatment, including the inhibition of autophagy, and increased phosphorylation levels of eIF2α in KG-treated KPC mice when compared to CG-treated mice. Our data suggests that a KG results in preservation of skeletal muscle mass. Additional research is warranted to explore whether this diet-treatment combination can be clinically effective in combating CAC in PDAC patients.
Smart Materials in Medical Gloves
Authors: Lovato Maria José , Valle Luis J. del , Puiggalí Jordi , Franco Lourdes
Published: June 2023

: Medical gloves, along with masks and gowns, serve as the initial line of defense against poten-tially infectious microorganisms and hazardous substances in the health sector. During the COVID-19 pandemic, medical gloves played a significant role, as they were widely utilized by society in daily activities as a preventive measure. These products demonstrated their value as important personal protection equipment (PPE) and reaffirmed their relevance as infec-tion-prevention tools. This review describes the evolution of medical gloves since the discovery of vulcanization by Charles Goodyear in 1839, which fostered the development of this industry. Regarding the current market, a comparison of the main properties, benefits, and drawbacks of the most widespread types of sanitary gloves is presented. The most usual gloves are produced from natural rubber (NR), polyisoprene (IR), acrylonitrile butadiene rubber (NBR), polychloroprene (CR), polyethylene (PE), and poly(vinyl chloride) (PVC). Furthermore, the environmental impacts of the conventional natural rubber gloves manufacturing process and mitigation strate-gies, such as bioremediation and rubber recycling, are addressed. In order to create new smart medical gloves with improved properties, several biopolymers (e.g. poly(vinyl alcohol) and starch) and additives such as biodegradable fillers (e.g., cellulose and chitin), reinforcing fillers (e.g. silica and cellulose nanocrystals), and antimicrobial agents (e.g., biguanides and quaternary ammonium salts) have been evaluated. This paper covers these smart materials and describes different innovative prototypes of gloves and coatings designed with them.
How to Influence Privacy Behavior Using Cognitive Theory and Respective Determinant Factors
Authors: Ioannis Paspatis , Aggeliki Tsohou
Published: June 2023

Several studies have shown that the traditional way of learning is not optimal when we aim to improve ICT users’ actual privacy behavior. In this research, we present a literature review of the theories that are followed in other fields to modify human behavior. Our findings show that the cognitive theory and the health belief model present optimistic results. Further, we examine various learning methods and we conclude that experiential learning is advantageous compared to other methods. In this paper aggregate the privacy behavior determinant factors found in the literature and we use the cognitive theory to we synthesize a theoretical framework. The proposed framework can be beneficial to educational policy makers and practitioners, such as public and private schools, and universities. Also, our framework provides a fertile ground for more research on experiential privacy learning and privacy behavior enhancement.
Platelet-Rich Plasma Power Mix gel (ppm) - An Orthobiologic Optimization Protocol Rich in Growth Factors and Fibrin
Authors: Lana José Fábio Santos Duarte , Purita Joseph , Everts Peter Albert , Neto Palmerindo Mendonça , Jorge Daniel de Moraes Ferreira , Mosaner Tomas , Da Fonseca Lucas Furtado , Jeyaraman Madhan , Azzini Gabriel Ohana Marques , Huber Stephany Cares , Santos Gabriel Silva
Published: June 2023

Platelet and fibrin-rich orthobiologic products, such as autologous platelet concentrates, have been extensively studied and appreciated for their beneficial effects in multiple conditions. PRP and its derivatives, including PRF, have demonstrated encouraging outcomes in clinical and laboratory settings, particularly in the treatment of musculoskeletal disorders such as OA. Although PRP and PRF have distinct characteristics, they share similar properties. The relative abundance of platelets, peripheral blood cells and molecular components in these orthobiologic products stimulate numerous biological pathways. These include inflammatory modulation, augmented neovascularization, and delivery of pro-anabolic stimuli that regulate cell recruitment, proliferation, and differentiation. Furthermore, the fibrinolytic system, which is sometimes overlooked, plays a crucial role in musculoskeletal regenerative medicine by regulating proteolytic activity and promoting the recruitment of inflammatory cells and MSCs in areas of tissue regeneration, such as bone, cartilage, and muscle.
PRP acts as a potent signaling agent; however, it diffuses easily, while the fibrin from PRF offers a durable scaffolding effect that promotes cell activity. The combination of fibrin with hyaluronic acid, another well-studied orthobiologic product, has been shown to improve its scaffolding properties, leading to more robust fibrin polymerization. This supports cell survival, attachment, migration, and proliferation.
Therefore, the administration of the "power mix" containing HA and autologous PRP + PRF may prove to be a safe and cost-effective approach in regenerative medicine.
Evaluation of Potential Predictive Biomarkers for Defining Brain Radiotherapy Efficacy in NSCLC Patients with Brain Metastases: A Case Report and Review of Literature
Authors: Luciano Angelo , Liguori Luigi , Polcaro Giovanna , Sabbatino Francesco , Pepe Stefano
Published: June 2023

Non-small-cell lung cancer (NSCLC) is the second most common cancer worldwide, resulting in 1.8 million deaths/year. Most of the patients are diagnosed with a metastatic disease. Central Nervous System is one of the major metastatic sites. Brain metastases are associated with severe neurological symptoms, shorter survival and worst clinical outcomes. Brain radiotherapy and systemic oncological therapies are currently used for controlling both cancer progression and neurological symptoms. Brain radiotherapy includes stereotactic brain ablative radiotherapy (SBRT) or whole brain radiotherapy (WBRT). SBRT is applied for single or multiple (≤ 4) small lesions (< 3 cm), while WBRT represents the best treatment choice in case of multiple and large brain metastases. In both cases radiotherapy application can represent an overtreatment causing severe toxicities without achieving a significant clinical benefit. So far, some scores have been proposed to define the potential clinical benefits derived from brain radiotherapy. However, most of them are not well validated into clinical practice. In this article, by presenting a clinical case of a patient with advanced NSCLC carrying a BRAFV600E mutation and brain metastases, we review the variables as well as the potential applicable scores to be considered in order to predict clinical outcomes and benefits from brain radiotherapy in patients with NSCLC and brain metastases.
The Adoption of a Machine Learning Approach in a Big Data Concept to Predict Project Cost Budgeting in the Thai Auction Process of Procurement Management for a Construction Project
Authors: Kusonkhum Wuttipong , Srinavin Korb , Chaitongrat Tanayut
Published: June 2023

Big Data Technologies is one of the disruptive technologies that influence every business, including the construction industry. The Thai government is attempting to use machine learning technique from part of analytic by Big Data Technologies to forecast costs for public building projects. However, it was never developed, and They did not implement it with traditional data. In this study, traditional data is processed to predict the behavior of Thai government construction projects by using a machine learning model. Additionally, the data was collected from the government procurement system in 2019. There are eight input data including departmental groupings, project types, procurement methods, length, winning price over standard price, even criteria were examined, including winning price over budget and standard price above budget. Additionally, a range of classification techniques, including an artificial neural network (ANN), Decision tree (DC), K-nearest neighbor (KNN), were used in this study (ANN). According to the results, ANN has the greatest predicting accuracy with 78.9 percent after hyperparameter tuning. The study confirms that data from the Thai Government Procurement System can be usefully investigated using machine learning techniques from Big Data technologies.
Profil Pelajar Pancasila dalam Peribahasa Indonesia yang Mengandung Unsur Makanan dan Cita Rasanya
Authors: Puspitaningsih Lestari , Jin Xiaoyan
Published: June 2023

Peribahasa berkaitan dengan budaya dan bahasa suatu bangsa. Peribahasa Indonesia berjumlah banyak, di antaranya yang mengandung unsur makanan dan cita rasanya. Makanan merupakan kebutuhan pokok, cermin budaya, dan tradisi bangsa. Peribahasa Indonesia mengandung nilai karakter yang sesuai dengan profil pelajar Pancasila, yaitu beriman, bertakwa kepada Tuhan YME, berakhlak mulia, berkebinekaan global, bergotong royong, mandiri, bernalar kritis, dan kreatif. Artikel ini difokuskan pada (1) analisis jumlah peribahasa Indonesia yang mengandung unsur makanan, jenis makanan, dan cita rasanya; (2) analisis nilai karakter dalam peribahasa Indonesia yang berunsur makanan dan cita rasanya yang sesuai dengan profil pelajar Pancasila. Penelitian ini mengombinasikan metode kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa (1) terdapat 388 peribahasa yang mengandung unsur makanan dan cita rasanya; (2) diketemukan peribahasa yang sesuai dengan nilai karakter dalam profil pelajar Pancasila, kecuali nilai karakter berakhlak mulia terhadap alam.
Imajinasi Kemaritiman dalam Sastra Jawa Kuno Pra-Islam: Eksplorasi Bait Puisi Kakawin Sumanasāntaka, Bhomāntaka, dan Ghaṭotkacāśraya
Authors: Raya Moch. Khafidz Fuad
Published: June 2023

Artikel ini mengkaji bait sastra puisi Jawa Kuno (kakawin) tentang kemaritiman, yaitu laut dan masyarakat pesisir. Hanya sedikit teks klasik sastra Jawa Kuno yang membahas laut dan berbagai kegiatan perairan termasuk kondisi sosial budaya masyarakat pesisir. Dengan menggunakan studi dokumen dan metode penggalian data dokumentasi, artikel ini membahas tiga. Pertama, nelayan, ikan gajah gajamīna, dan pesisir pantai beserta sisi gelapnya. Kedua, joṅ sebagai kapal yang dipadankan dengan jukuṅ, sambo, dan sāmwau. Ketiga, visualisasi keindahan pantai sebagai destinasi menawan dalam imajinasi sastra Jawa Kuno. Pesona estetika laut beserta segala sesuatu yang melingkupinya menjadi daya tarik para penguasa dan raja-raja Jawa untuk mempertahankan wilayahnya. Artikel ini berkontribusi memvisualisasi kemaritiman dalam sastra puisi Jawa Kuno (kakawin) yang tidak dibahas dalam beberapa kajian sejarah dan arkeologi pada masa Islam di Jawa.
Tradisi Pengucapan Syukur Minahasa dan Pemertahanan Kuliner Tradisional
Authors: Sondakh Sonya Indriati , Yoesoef M.
Published: June 2023

Pengucapan syukur Minahasa merupakan tradisi panen yang dirayakan setiap tahun, yang mempertemukan ritual religi Kristen dan ritual religi tradisional masyarakat Minahasa pra-Kristen. Ritual-ritual yang sakral maupun yang profan melibatkan makanan yang berlimpah. Tradisi pengucapan syukur merupakan wujud rasa bersyukur kepada Tuhan Yang Maha Besar (Opo Empung Wailan Wangko) atas berkat keberhasilan panen. Terkait makanan dalam tradisi panen ini, nasi jaha yang dimasak dalam bambu dan dodol merupakan makanan yang wajib dihadirkan untuk dimakan di tempat perayaan dan/atau dibawa pulang sebagai oleh-oleh. Artikel ini mendiskusikan bagaimana kuliner tradisional Minahasa, terutama yang dimasak dalam bambu, menjadi salah satu unsur yang membuat tradisi ini tetap bertahan kendati ada kendala-kendala dalam perayaan tahunan. Penelitian ini memperoleh data melalui kajian kepustakaan, wawancara, dan observasi di lapangan yang dilengkapi dokumentasi.
Sekar Pambayun dan Raden Rangga: Representasi Budaya Keagrarisan dan Kemaritiman
Authors: Susanti Theresia Nia , Wicaksono Yoga Pradana , Macaryus Sudartomo
Published: June 2023

Artikel ini bertujuan mengeksplorasi representasi budaya keagrarisan dan kemaritiman yang ditampakkan pada tokoh Sekar Pambayun dan Raden Rangga dalam novel Sihir Pambayun (SP) karya Joko Santosa. Novel tersebut sebagai sumber data primer. Data berupa rangkaian peristiwa dengan konteksnya masing-masing dihimpun melalui pembacaan. Data pendukung diperoleh melalui studi pustaka berupa artikel, berita, seni pertunjukan, dan memori kolektif masyarakat Mangir. Analisis data dilakukan secara terus-menerus sejak tahap penyediaan data dengan tahapan identifikasi, klasifikasi, dan interpretasi. Identifikasi dilakukan dengan menempatkan setiap data yang menunjukkan ciri atau berkaitan dengan budaya keagrarisan dan kemaritiman yang sekaligus sebagai dasar klasifikasi data. Interpretasi data dilakukan secara kontekstual dengan menempatkan setiap data sebagai bagian dari keseluruhan dan hubungan antardata secara keseluruhan. Hasil penelitian menunjukkan bahwa Sekar Pambayun merepresentasikan budaya keagrarisan dalam relasinya dengan keluarga, mitra, dan lawannya. Raden Rangga merepresentasikan budaya kemaritiman dengan kembalinya ke pangkuan ibundanya Kanjeng Ratu Kidul dan menyatu dengan laut dan menjauhi darat.
Religious Hybridity of Asian Diaspora: A Postcolonial Criticism on The Buddha of Suburbia and Anita and Me
Authors: Fajar Yusri
Published: June 2023

This article investigated the negotiation of Islamic and Hindu beliefs held by South Asian immigrants in British society, which resulted in religious hybridity as depicted in two diasporic fictions, The Buddha of Suburbia by Hanif Kureishi and Anita and Me by Meera Syal. This was a qualitative study. Data was collected through document studies of the two novels. The data were then analyzed using content analysis techniques in conjunction with cultural hybridity theory. The findings indicated that the religious practices of the British Asian diaspora were ambiguous. On the one hand, they continued to practice Islam and Hinduism, while on the other, they attempted to reconcile their religious beliefs with the religious, social, and cultural aspects of British society.
Level attack of caterpillar on oil palm (Elaeis guineensis Jacq.) plantations in Dharmasraya District, West Sumatera Province, Indonesia
Authors: Ikhsan Zahlul , Suhendra Dede , Hidrayani Hidrayani , Kurniawati Sholih , Tania Reza
Published: June 2023

Caterpillars are insects that eat oil palm leaves. As a herbivore, its presence and feeding activity will be affected by the growth phase of the host plant. This study aims to determine the percentage and intensity of caterpillar attacks on oil palm (Elaeis guineensis Jacq.) which have not yet produced fruit in Dharmasraya Regency. The research was carried out in July-September 2022 and the location was determined using a purposive sampling method. The research was conducted in two immature oil palm plantations (Nagari Silago and Timpeh) and two mature areas (Nagari Sitiung and Muaro polite). Determination of sample plants was carried out diagonally and taken ± 10% of the total population of palms. The caterpillars found during the research in the oil palm plantations of Dharmasraya Regency consisted of 2 species, namely Setora nitens and Setothosea asigna. At the four study locations, the average percentage of infected plants, infected midribs, and attack intensity were 43.47; 40.71; and 19.86 %. Immature oil palm plants have a higher rate of fireworm attacks than mature ones.
PENGUATAN PERAN PEREMPUAN DALAM PENDIDIKAN: PEMBERDAYAAN PARA USTADZAH PESANTREN MUHAMMADIYAH KABUPATEN MADIUN DALAM MENGAKSES KITAB BERBAHASA ARAB GUNDUL
Authors: Cahyo Agus Tri
Published: June 2023

Banyak peran yang dimainkan para perempuan (baca: para ustadzah) di Pesantren Muhammadiyah kabupaten Madiun. Hal ini tentunya tidak lepas dari dua misi besar yang dikembangkan oleh Muhammadiyah, yaitu tajrîd dan tajdîd. Tajrîd  artinya pemurnian,  yaitu melakukan proses pembersihan dari sinkretisme yang ada pada cara beribadah warganya. Sedangkan tajdîd berarti adanya upaya pembaharuan dalam memahami Islam, khususnya dalam hal-hal yang terkait dengan ranah peradaban. Para perempuan di pesantren Muhammadiyah berupaya untuk bisa melaksanakan dua misi besar tersebut. Hal ini terlihat dengan banyaknya peran yang dimainkan di pesantren, sejak dari bergabungnya dalam pengelolaan lembaga Darul Qur’an yang melakukan pembelajaran al-Qur’an metode ummi, kegiatan pesantren Sabtu Ahad, pembinaan seni beladiri Tapak Suci Putra Muhammadiyah, penanganan anak asuh dan pelibatan pada penanganan kelompok bermain. Namun hal yang masih mengganjal adalah minimnya peran perempuan dalam pembelajaran kepesantrenan, khususnya dalam pembelajaran kitab berbahasa Arab. Pengabdian ini dilakukan dalam rangka pemberdayaan problem dimaksud.
PENINGKATAN KETERAMPILAN MENGAJAR MATERI IPA DAN MATEMATIKA BERBASIS LABORATORIUM BAGI GURU KELAS MADRASAH IBTIDAIYAH DI KECAMATAN MLARAK, PONOROGO
Authors: Hidayati Kurnia , Wathoni Kharisul , Widayanti Esti Yuli
Published: June 2023

Kegiatan ini merupakan program Pengabdian kepada Masyarakat dari dosen di lingkup Institut Agama Islam Negeri Ponorogo pada tahun 2021. Dengan mengacu pada kluster pengabdian peningkatan program studi  maka pengabdian  ini  memilih  sasaran  madrasah  ibdidaiyah  di lingkup  kabupaten  Ponorogo.  Sasaran  dari  Pengabdian  adalah  guru kelas  madrasah  ibtidaiyah  di  kecamatan  Mlarak  sebanyak  25  orang guru. Tujuan dari program pengabdian adalah meningkatkan keterampilan guru kelas dalam pembelajaran berbasis laboratorium untuk pembelajaran materi IPA dan matematika. Metode pengabdian yang digunakan adalah dengan pendekatan edukatif dalam bentuk pelatihan atau workshop. Workshop dilaksanakan dengan strategi pembelajaran langsung menggunakan teknik ceramah, diskusi, demonstrasi, dan praktik. Output atau luaran dari kegiatan pengabdian ini adalah guru kelas yang terampil dalam melaksanakan langkah- langkah pengajaran matematika dan IPA berbasis laboratorium serta guru yang terampil dalam penggunaan alat laboratorium untuk pembelajaran materi IPA dan matematika.
SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response
Authors: Dziembowski Andrzej , Krawczyk Pawel , Mroczek Seweryn , Gewartowska Olga , Mazur Michał , Orzeł Wiktoria , Matylla-Kulińska Katarzyna , Jeleń Sebastian , Turowski Paweł , Śpiewla Tomasz , Tarkowski Bartosz , Tudek Agnieszka , Brouze Aleksandra , Wesołowska Aleksandra , Nowis Dominika , Gołąb Jakub , Kowalska Joanna , Jemielity Jacek
Published: June 2023

Though mRNA vaccines against COVID-19 have revolutionized vaccinology and have been administered in billions of doses, we know incredibly little about how mRNA vaccines are metabolized in vivo. Here we implemented enhanced nanopore Direct RNA sequencing (eDRS), to enable the analysis of single Moderna’s mRNA-1273 molecules, giving in vivo information about the sequence and poly(A) tails.

We show that mRNA-1273, with all uridines replaced by N1-methylpseudouridine (mΨ), is terminated by a long poly(A) tail (~100 nucleotides) followed by an mΨCmΨAG sequence. In model cell lines, mRNA-1273 is swiftly degraded in a process initiated by the removal of mΨCmΨAG, followed by CCR4-NOT-mediated deadenylation. In contrast, intramuscularly inoculated mRNA-1273 undergoes more complex modifications. Notably, mRNA-1273 molecules are re-adenylated after mΨCmΨAG removal. Detailed analysis of immune cells involved in antigen production revealed that in macrophages, after mΨCmΨAG removal, vaccine mRNA is very efficiently re-adenylated, and poly(A) tails can reach up to 200A. In contrast, in dendritic cells, vaccine mRNA undergoes slow deadenylation-dependent decay. We further demonstrate that enhancement of mRNA stability in macrophages is mediated by TENT5 poly(A) polymerases, whose expression is induced by the vaccine itself. Lack of TENT5-mediated re-adenylation results in lower antigen production and severely compromises specific immunoglobulin production following vaccination.

Together, our findings provide an unexpected principle for the high efficacy of mRNA vaccines and open new possibilities for their improvement. They also emphasize that, in addition to targeting a protein of interest, the design of mRNA therapeutics should be customized to its cellular destination.
Effects of spirulina (Spirulina platensis) supplementation in feed on reproductive performance in rabbit (Oryctolagus cuniculus) does
Authors: Momo Chongsi Margaret Mary Mary , Adam Mahamat Tahir Markhous , Hervé Tchoffo , Magloire Bend Emma Fortune , Narcisse Vemo Bertin , Bertine Noumbissi Marie Noel , Ferdinand Ngoula , Joseph Tchoumboue
Published: June 2023

The aim of this study was to evaluate the effect of dietary supplementation with spirulina powder on the reproductive characteristics in female rabbits. Twenty-one nulliparous and sexually mature rabbits (8 months old) were divided into 3 groups of 7 animals each, comparable in terms of body weight. After one week of feeding with the experimental diet, rabbits in each group were mated. During the experiment, does in group 1 (control group) received ad libitum a diet without spirulina (control diet), while does of groups 2 and 3 received diets supplemented with spirulina powder at 0.6% and 1.2% respectively. compared to control group, the live weights of animals treated with spirulina increased, while there was no significant difference (P > 0.05). The male acceptance and kids viability rates were insignificantly (P > 0.05) higher and the delay of male acceptance was lower in females fed diet containing spirulina as compared to control females. The rate of fertility, the sex ratio males/females of the young and duration of gestation were comparable in all the groups (P > 0.05). The number of young rabbits post-partum was insignificantly (P > 0.05) greater in does receiving spirulina-supplemented feed than control animals. Therefore, the results from this work show that supplementation of diet with spirulina powder could ameliorate reproductive performances in female rabbits, especially at 1.2%, as better performances were recorded at this percentage.
Interpretable scRNA-seq Analysis with Intelligent Gene Selection
Authors: Zhang Xinyu , Jin Kaixiu , Ni Tianhao , Pei Guanxiong , Xue Nan , Yan Guanao , Li Taihao , Li Bingjie
Published: June 2023

Single-cell RNA sequencing (scRNA-seq) data analysis is confronted with multiple challenges, including high dimensionality, substantial noise, and information loss. To effectively address these issues, we introduce scAIG, a robust and transparent single-cell analysis framework. scAIG utilizes an intelligent gene selection method, which systematically identifies the most informative genes for clustering based on the Normalized Mutual Information (NMI) between the pre-learned pseudo-labels and quantified genes. Furthermore, scAIG incorporates a scale-invariant distance for assessing cell-to-cell similarity, which enhances connection between homologous cells and ensures more accurate and robust results. Through comprehensive comparisons with existing state-of-the-art techniques, scAIG demonstrates superior performance in both clustering accuracy and visualization quality. Our in-depth analysis of the clustering results further reveals that scAIG can uncover intricate stage-specific gene expression patterns during the same period of cell development.
Accurate and Generalizable Soil Liquefaction Prediction Model Based on the CatBoost Algorithm
Authors: He Jiazhi , Feng Xianda , Lu
Published: June 2023

Accurate prediction of soil liquefaction is important for preventing geological disasters. Soil liquefaction prediction models based on machine learning algorithms are efficient and accurate; however, the generalizability of some models is weak and they fail to achieve highly precise soil liquefaction predictions in certain areas, which limits the applicability of these models. Thus, a soil liquefaction prediction model was constructed using the CatBoost (CB) algorithm to support categorical features. The model was trained using standard liquefaction datasets from domestic and foreign sources and was optimized with Optuna hyperparameters. Additionally, the model was evaluated using five evaluation metrics and its performance was compared to that of other models that use multi-layer perceptron and support vector machine algorithms. Finally, the prediction capability of the model was verified by a case study. The experimental results demonstrated that the CB-based model generated more accurate soil liquefaction predictions than other comparison models and maintained their performance. Hence, the proposed model accurately predicts soil liquefaction and offers strong generalizability, demonstrating potential to contribute toward the prevention and control of soil liquefaction in engineering projects, and toward ensuring the safety and stability of structures built on or near liquefiable soils.
Preparation and Properties of the WSCR/PVDF Hybrid Ultrafiltration
Authors: dong yanmao
Published: June 2023

The wide use of selective catalytic reduction (Selective Catalytic Reduction, SCR) technology produces a large number of waste SCR catalysts (waste selective catalytic reduction, WSCR). In order to reuse WSCR, an organic-inorganic hybrid ultrafiltration membrane (PVDF/WVCR) was prepared from WSCR and polyvinylidene fluoride (PVDF). WSCR was analyzed by scanning electron microscope with energy dispersive spectrometer (SEM-EDS), X-ray powder diffraction (XRD) instrument, Fourier transform infrared spectroscopy (FTIR). Results showed that the particle size of WSCR was 5-40 μm and contained elements including O, Ti, Si, Ca, Al, Mo, Fe and V. WSCR hybrid PVDF (PVDF/WSCR) ultrafiltration membrane was prepared by blending method, and the effect of the amount of WSCR on membrane properties was investigated. The contact angle of PVDF/WSCR was smaller than that of pure PVDF. The hydrophilicity of the PVDF/WSCR membrane was enhanced by WSCR.The humic acid retention of PVDF/WSCR reached 78%. The results provide new ideas for reuse WSCR to reduce the cost of ultrafiltration membrane and improve the performance of PVDF ultrafiltration membrane.
Effectiveness of a Hysteroscopic Tissue Removal System Device for Hysteroscopic Myomectomy on Patients’ Quality of Life: A Randomized Clinical Trial
Authors: TAM Teresa , JUAREZ Lourdes
Published: June 2023

Purpose: To evaluate the quality of life in patients treated for submucosal leiomyomas after hysteroscopic myomectomy compared to medical therapy. This is the first prospective randomized analysis comparing outcomes of medical therapy versus hysteroscopic myomectomy using the TruClear™ hysteroscopic tissue removal system to treat heavy menstrual bleeding from submucosal leiomyoma(s).
Methods: Setting: private practice and community-based hospital; subjects: female patients with symptomatic submucosal leiomyomas from 2014-2017. A total of 69 patients enrolled, with 47 completed. Statistical analysis used: randomized clinical trial. Each patient was randomized to oral contraceptive pills/progesterone releasing intrauterine device or hysteroscopic myomectomy. Each patient was to complete the Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) questionnaire at baseline, one month, three months, and greater than or equal to six months after treatment. Main outcome measured: Primary outcome was the health-related quality of life (HR-QOL), as reflected from UFS-QOL scores. Contrasts were constructed from a linear mixed-effects model to compare the two treatment groups for changes from baseline in UFS-QOL scores.
Results: UFS-QOL scores were similar at baseline between the two treatment groups. There was an overall improvement in all UFS-QOL scores within each group. Higher improvement scores were noted in the surgical group compared to the medical group for almost all UFS-QOL scores. At ≥6 months, in comparison to the medically managed patients, the most considerable score improvements for the surgical group were reported in HR-QOL concern, activities, self-consciousness and symptom severity scores having mean change scores (95% CIs) of 35.3, 28.9, 28.6, and 32.2, respectively.
Conclusion: Although there was no statistical difference in the change degree of improvement of overall quality of life among patients with symptomatic submucosal leiomyomas who received medical or surgical treatments in the study, there were greater differences in improvements in health-related quality of life scores over time after surgical treatment.
Does environmental water management promote invasive fish? Modelling the response of common carp (Cyprinus carpio) to natural and managed flows using a stochastic population model
Authors: Todd Charles Robert , Koehn John D , Stuart Ivor G , Wootton Henry F , Zampatti Brenton P , Thwaites Leigh , Conallin Anthony , Ye Qifeng , Stamation Kasey , Bice Chris
Published: June 2023

Common carp (Cyprinus carpio; hereafter carp) is a highly invasive freshwater fish that has colonised river basins across the world causing ecological degradation. In regulated rivers, restoration of natural flow regimes to rehabilitate aquatic ecosystems is a primary focus of environmental management, yet some actions (e.g., environmental water delivery or artificial floodplain inundations) may have unintended consequences including favouring carp. We developed a stochastic population model to represent carp population responses to hydrology and management actions. The model uses current understanding of carp life history, including different survival rates of early life-stages for a range of habitat types, to estimate population responses to various flow/inundation scenarios. Using case studies from two major regions of a large, regulated dryland river, we demonstrate that large natural floods and prolonged droughts accounted for the greatest amplitude of projected carp population increases and declines, respectively. Within-channel flow pulses and small floods, which are a primary focus of environmental flows, appeared to have little influence on long-term carp population trajectories. Artificial inundations generated by floodplain infrastructure, however, caused significant carp recruitment compared to baseline scenarios. Large natural floodplain inundations also maintained high carp biomasses and thus likely high impacts on natural ecological values. The carp population model captures the response of carp to flows and artificial floodplain inundation and will inform environmental managers on the likely trade-offs between achieving restoration of natural ecological values and suppressing a globally invasive fish.
A Bioinformatics-Based Analysis of an Anoikis-Related Gene Signature Predicts the Prognosis of Patients with pancreatic adenocarcinoma
Authors: Liu Xizhi , Gu Shanzhi , Zhao Xinhan , Zhang Yujiao
Published: June 2023

Background Anoikis acts as an important defense for the organism by preventing shedding tumor cells from re-adhering to incorrect locations and preventing their growth. In this study, anoikis-related genes (ARGs) were used to construct a prognostic model for PAAD patients.Methods TCGA database was used to acquire RNA sequencing data and clinical information for PAAD samples. The Cox regression analysis, LASSO regression were performed to construct the prognostic ARGs signature. In addition, GSEA, GO, KEGG were performed to investigate the potential molecular mechanism. Moreover, we analyzed the relationship between our identified signature and immune cell infiltration, tumor microenvironment, mutation landscape, immunotherapy response, drug sensitivity analysis.Results Two ARGs were slected, including MET and SLCO1B3. Finally, in vitro experiments we performed qRT-PCR, western blot, scratch test, colony-formation analysis to validate the expression and function of MET gene.Conclusion Combined with clinicopathological characteristics, the risk model was validated as a new independent prognostic factor for PAAD.
Non-Monotone Exponential Time (NEXT) Model for the Longitudinal Trend of a Continuous Outcome in Clinical Trials
Authors: Duan Ran , Chen Kaiyi , Du Yu , Kulkarni Pandurang , Qu Yongming
Published: June 2023

The dose response curve has been studied extensively for decades. However, most
of these methods ignore intermediate measurements of the response variable and only
use the measurement at the endpoint. In early phase trials, it is crucial to utilize all
available data due to the smaller sample size. Simulation studies have shown that the
longitudinal dose-response surface model provides a more precise parameter estima-
tion compared to the traditional dose response only using data from the primary time
point. However, the current longitudinal models with parametric assumptions assume
that the treatment effect increases monotonically over time, which may be controversial
to reality. We propose a parametric non-monotone exponential time (NEXT) model,
an enhanced longitudinal dose-response model with greater flexibility, capable of ac-
commodating non-monotonic treatment effect and making predictions for longer-term
efficacy. In addition, the estimator for the time to maximum treatment effect and its
asymptotic distribution has been derived from NEXT. Extensive simulation studies us-
ing known data-generating models and using real clinical data showed that the NEXT
model outperformed the existing monotone longitudinal models.
Local versus regional contributions to PM10 levels in the western Mediterranean
Authors: Clemente Álvaro , Galindo Nuria , Nicolás Jose F. , Crespo Javier , Pastor Carlos , Yubero Eduardo
Published: June 2023

In this study, PM10 daily samples were collected every day during approximately one month in winter and one month in summer, 2019. Sampling was performed simultaneously at two different locations: an urban traffic site (∼ 80 m a.s.l.) and a regional background station (∼ 1500 m a.s.l.) in the Western Mediterranean. The objective of this work was to investigate PM10 sources at both sites in order to determine regional and urban contributions to aerosol levels. Seven factors were obtained at both sites using Positive Matrix Factorization (PMF): Saharan dust, Aged sea salt, Ammonium sulfate, Nitrate, Road traffic, Local dust and Fresh sea salt. At the urban site, the contribution of vehicle related-sources (Road traffic, Nitrate and Local dust) was significantly higher in winter (∼80%) than in summer (∼60%).
Unusual photodynamic characteristics of light-oxygen-voltage domain of phototropin linked to terrestrial adaptation of Klebsormidium nitens
Authors: Sharma Sunita , Gautam Avinash , Gourinath samudrala , Kateriya Suneel
Published: June 2023

Phototropin (Phot), a blue light sensing LOV domain protein, mediates blue light responses and is evolutionary conserved across the green lineage. Klebsormidium nitens, a green terrestrial alga, presents a valuable opportunity in studying adaptive responses from aquatic to land habitat transitions. We determined the crystal structure of Klebsormidium nitens Phot LOV1 domain (KnLOV1) in the dark and engineered different mutations (R60K, Q122N, D33N) to modulate the lifetime of photo recovery cycle. We observed an unusual slow recovery in native KnLOV1 domain (τ = 2467 seconds) compared to different mutants (R60K: τ = 122 seconds, Q122N: τ = 101 seconds, D33N: τ = 580 seconds). Crystal structures of native KnLOV1 and mutants revealed subtle but critical changes near the protein chromophore that is responsible for modulating protein recovery rate. Our findings shed light on the unique structural characteristics of the newly studied KnLOV1 and its evolutionary importance for phototropin mediated physiology.