bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifikasi Fitur untuk Prediksi Penerimaan Program Listrik Prabayar: Kasus di PLN Tahuna
Authors: Riduwan Eko , Purwitasari Diana , Raharjo Agus Budi
Published: August 2022

Listrik Prabayar (LPB) memberikan manfaat bagi perusahaan listrik dalam hal mengurangi piutang pelanggan dan memberikan kemudahan pengendalian pemakaian listrik bagi pelanggan. Perusahaan Listrik Negara (PLN) mempunyai program pemasaran untuk berpindah (migrasi) dari listrik pascabayar menjadi LPB. Pencapaian Key Performance Indicator (KPI) Program Pemasaran LPB PLN Tahuna pada 2021 hanya 1.185 pelanggan dari taget 2.261 pelanggan. Hal ini memberikan peluang perbaikan karena program pemasaran saat ini belum mengoptimalkan penggunaan data sebagai dasar penentuan prospek pelanggan. Penelitian ini mengajukan metode identifikasi fitur dan skenario pemilihan algoritma Pembelajaran Mesin yang tepat untuk memprediksi penerimaan pelanggan listrik pasca bayar terhadap program prabayar. Identifikasi fitur dilakukan dengan pengukuran korelasi Pearson. Kandidat algoritma Pembelajaran Mesin yang terpilih adalah Logistic Regression, Support Vector Machines, Decision Tree, dan Random Forest. Model-model yang dihasilkan dievaluasi menggunakan confusion matrix sehingga didapatkan model terbaik untuk studi kasus yang diajukan. Penelitian menunjukkan bahwa fitur tarif, daya, frekuensi terlambat membayar listrik, pemakaian rata-rata listrik bulanan (kWh) dan Kabupaten mempunyai korelasi signifikan dengan penerimaan LPB. Adapun model dengan algoritma Random Forest adalah model terbaik sesuai tujuan penelitian dengan F1-Measure tertinggi (95,17%).
Pemanfaatan Machine Learning untuk Pengelompokan dan Prediksi Target Tambah Daya Listrik Pelanggan Prabayar (Studi Kasus : PT PLN ULP Watang Sawitto)
Authors: Afthoni Rizqa , Purwitasari Diana , Raharjo Agus Budi
Published: August 2022

Perkembangan teknologi sistem informasi dan ilmu pengetahuan khususnya dalam bidang pemasaran membuat para pelaku usaha berupaya untuk meningkatkan competitive advantage mereka dengan mengerahkan sumber daya yang dimiliki oleh perusahaan. Perusahaan dituntut untuk berinovasi dalam mengelola perusahaannya agar dapat bertahan dalam dunia persaingan. Kemampuan untuk memprediksi pelanggan prabayar yang berpotensi tambah daya listrik merupakan salah satu strategi pendukung untuk keberhasilan program pemasaran tambah daya pelanggan berdasarkan karakteristik konsumsi listriknya. Berdasarkan hal tersebut, penelitian ini mengajukan metode prediksi pelanggan prabayar dengan memanfaatkan algoritma pengelompokan (Clustering) dan klasifikasi. Data yang diolah adalah data pelanggan prabayar tarif rumah tangga yang memiliki fitur variabel daya listrik pelanggan (VA), frekuensi beli token listrik, total pemakaian kWh, total rupiah pembelian token, selisih daya VA pelanggan, jam nyala, periode hari pembelian token listrik, dan riwayat tambah daya listrik pelanggan. Pengelompokan dilakukan dengan menerapkan algoritma K-means. Dari hasil tersebut, model prediksi dibangun sesuai target setiap klaster dengan memanfaatkan dua metode, Gradient Boosting dan Artificial Neural Network. Evaluasi prediksi model terbaik dilakukan dengan menerapkan tiga skenario proporsi data latih dan data uji, yang selanjutnya diukur menggunakan matrik akurasi dan Cohen Kappa. Hasil eksperimen menghasilkan empat klaster berdasarkan karakteristik konsumsi listriknya. Gradient Boosting memberikan hasil yang terbaik untuk semua klaster, untuk klaster 1 menghasilkan nilai AUC 0.784, klaster 2 menghasilkan nilai AUC 0.941, klaster 3 menghasilkan nilai 0.884 dan klaster 4 menghasilkan nilai AUC 0.903.
Penyelesaian Masalah Transportasi Menggunakan Metode RCWMCAM dan Metode MODI
Authors: Kamalia Aqilah , Utomo Robertus Soelistyo
Published: August 2022

Masalah transportasi merupakan bagian dari program linier yang berkaitan dengan meminimalkan biaya pendistribusian barang dari sejumlah sumber ke sejumlah tujuan dengan keterbatasaan persediaan dan permintaan. Penyelesaian masalah transportasi disebut dengan solusi fisibel awal dan solusi optimal. Solusi fisibel awal yang diperoleh akan berpengaruh terhadap solusi optimal sehingga penting untuk menentukan metode yang dipakai dalam menentukan solusi fisibel awal. Metode RCWMCAM merupakan metode yang digunakan untuk mendapatkan solusi fisibel awal dengan mempertimbangkan perhitungan baris dan kolom baik biaya penalti dan biaya minimum. Metode MODI merupakan metode yang digunakan untuk menentukan solusi optimal masalah transportasi. Artikel ini membahas tentang penyelesaian masalah trasnportasi menggunakan Metode RCWMCAM dan Metode MODI. Pengaplikasian Metode RCWMCAM pada artikel ini memperoleh solusi fisibel awal yang sama dengan solusi optimal sehingga solusi fisibel awal yang dipeorleh dikatakan telah optimal.
A inclusão social de gênero em ações de divulgação científica de museus de ciências
Authors: Silva Anelissa Carinne dos Santos , Da Silva Camila Silveira
Published: August 2022

O presente artigo se apoia no Estudo de Caso para apresentar a análise de entrevistas de coordenadoras dos projetos Meninas com Ciência (Museu Nacional) e Meninas no Museu (Museu de Astronomia e Ciências Afins1), em uma perspectiva da inclusão social de gênero. No recorte explorado, foi analisada a categoria emergente intitulada de Impactos dos Projetos, orientada pela Análise de Conteúdo fundamentada pelos referenciais teóricos de Estudos de Gênero e Divulgação Científica em Museus. Os resultados evidenciaram a potencialidade dos dois projetos para a inclusão social de gênero por meio de ações para a inserção de meninas em atividades de mediação e debates que resultaram em percepção positiva sobre pertencimento, sororidade, dentre outros.
Green synthesis of silver nanoparticles through oil: Promoting full-thickness cutaneous wound healing in methicillin-resistant Staphylococcus aureus infections
Authors: Wang Yuhan , Li Qinmei , Peng Xiaomin , Li Zheng , Xiang Jun , Chen Yunru , Hao Kaiyuan , Wang Shuaiyang , Nie Dongyang , Cui Yao , Lv Feifei , Wang Ying , Wu Wenda , Guo Dawei , Si Hongbin
Published: August 2022

Due to the emergence of multi-drug resistant microorganisms, the development and discovery of alternative eco-friendly antimicrobial agents have become a top priority. In this study, a simple, novel, and valid green method was developed to synthesize Litsea cubeba essential oil-silver nanoparticles (Lceo-AgNPs) using Lceo as a reducing and capping agent. The maximum UV absorbance of Lceo-AgNPs appeared at 423 nm and the size was 5–15 nm through transmission electron microscopy result. The results of Fourier transform infrared and DLS showed that Lceo provided sufficient chemical bonds for Lceo-AgNPs to reinforce its stability and dispersion. The in vitro antibacterial effects of Lceo-AgNPs against microbial susceptible multidrug-resistant Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA) were determined. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Lceo-AgNPs against E. coli were 25 and 50 μg/ml. The MIC and MBC of Lceo-AgNPs against MRSA were 50 and 100 μg/ml, respectively. The results of scanning electron microscopy showed that the amount of bacteria obviously decreased and the bacteria cells were destroyed by Lceo-AgNPs. In vivo research disclosed significant wound healing and re-epithelialization effects in the Lceo-AgNPs group compared with the self-healing group and the healing activity was better than in the sulfadiazine silver group. In this experiment, Lceo-AgNPs has been shown to have effects on killing multidrug-resistant bacteria and promoting wound healing. This study suggested Lceo-AgNPs as an excellent new-type drug for wound treatment infected with multidrug-resistant bacteria, and now expects to proceed with clinical research.
Anterior cruciate ligament deficiency versus intactness for outcomes in patients after unicompartmental knee arthroplasty: a systematic review and meta-analysis
Authors: Guo Weiming , Wan Teng , Tan Haifeng , Fan Gang , Gao Xiaoyu , Liu Pan , Jiang Changqing
Published: August 2022

Objective: The unicondylar knee arthroplasty (UKA) procedure is primarily indicated for osteoarthritis of the knee. Anterior cruciate ligament (ACL) defects have long been considered a contraindication to UKA. However, recent clinical studies have found that ACL defects do not affect postoperative outcomes in UKA. To elucidate whether ACL defects affect postoperative outcomes in UKA, we performed a systematic review and Meta-analysis of observational cohort studies comparing the effects of ACL defects and intactness on surgical outcomes in UKA.

Methods: In this study, we used “Anterior Cruciate Ligament”, “Anterior Cruciate Ligament Injuries” and “Arthroplasty, Replacement, Knee” as the subject terms according to PICOS principles. These subject terms and the corresponding free texts were used to conduct a systematic search in the three major databases PubMed, Embase and Cochrane on December 9, 2021. The main study variables included age, gender, region, definition of ACL defect and diagnosed diseases. The study used a random effect model to pool the effect of 95% CIs. To explore the sources of heterogeneity and to test the stability of the results, a sensitivity analysis was performed.

Results: The systematic review found no significant differences in postoperative clinical outcomes in the elderly population when unicondylar replacement was performed in the setting of multiple factors such as injury, defects, longitudinal tear, and synovial bursa injury defined as ACL deficiency. The primary clinical outcomes included postoperative revision, Tegner activity score, and Oxford Knee Score (OKS). After statistical meta-analysis, postoperative outcomes such as postoperative revision (OR, 1.174; 95% CIs, 0.758–1.817) and Tegner activity score (OR, -0.084; 95% CIs, -0.320–0.151) were not statistically different.

Conclusion: There was no difference in postoperative revision rates and functional outcomes such as Tegner activity score between the ACL-deficient group compared with the ACL-intact group. For the present results, it is not advisable to consider ACL deficiency as a contraindication of UKA.
Inactivation of human plasma alters the structure and biomechanical properties of engineered tissues
Authors: Rosell-Valle Cristina , Martín-López María , Campos Fernando , Chato-Astrain Jesús , Campos-Cuerva Rafael , Alaminos Miguel , Santos González Mónica
Published: August 2022

Fibrin is widely used for tissue engineering applications. The use of blood derivatives, however, carries a high risk of transmission of infectious agents, necessitating the application of pathogen reduction technology (PRT). The impact of this process on the structural and biomechanical properties of the final products is unknown. We used normal plasma (PLc) and plasma inactivated by riboflavin and ultraviolet light exposure (PLi) to manufacture nanostructured cellularized fibrin-agarose hydrogels (NFAHs), and then compared their structural and biomechanical properties. We also measured functional protein C, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and coagulation factors [fibrinogen, Factor (F) V, FVIII, FX, FXI, FXIII] in plasma samples before and after inactivation. The use of PLi to manufacture cellularized NFAHs increased the interfibrillar spacing and modified their biomechanical properties as compared with cellularized NFAH manufactured with PLc. PLi was also associated with a significant reduction in functional protein C, FV, FX, and FXI, and an increase in the international normalized ratio (derived from the PT), APTT, and TT. Our findings demonstrate that the use of PRT for fibrin-agarose bioartificial tissue manufacturing does not adequately preserve the structural and biomechanical properties of the product. Further investigations into PRT-induced changes are warranted to determine the applications of NFAH manufactured with inactivated plasma as a medicinal product.
Translating advances in microbial bioproduction to sustainable biotechnology
Authors: Carruthers David N. , Lee Taek Soon
Published: August 2022

Advances in synthetic biology have radically changed our ability to rewire microorganisms and significantly improved the scalable production of a vast array of drop-in biopolymers and biofuels. The success of a drop-in bioproduct is contingent on market competition with petrochemical analogues and weighted upon relative economic and environmental metrics. While the quantification of comparative trade-offs is critical for accurate process-level decision making, the translation of industrial ecology to synthetic biology is often ambiguous and assessment accuracy has proven challenging. In this review, we explore strategies for evaluating industrial biotechnology through life cycle and techno-economic assessment, then contextualize how recent developments in synthetic biology have improved process viability by expanding feedstock availability and the productivity of microbes. By juxtaposing biological and industrial constraints, we highlight major obstacles between the disparate disciplines that hinder accurate process evaluation. The convergence of these disciplines is crucial in shifting towards carbon neutrality and a circular bioeconomy.
The transcription factor Zfp503 promotes the D1 MSN identity and represses the D2 MSN identity
Authors: Shang Zicong , Yang Lin , Wang Ziwu , Tian Yu , Gao Yanjing , Su Zihao , Guo Rongliang , Li Weiwei , Liu Guoping , Li Xiaosu , Yang Zhengang , Li Zhenmeiyu , Zhang Zhuangzhi
Published: August 2022

The striatum is primarily composed of two types of medium spiny neurons (MSNs) expressing either D1- or D2-type dopamine receptors. However, the fate determination of these two types of neurons is not fully understood. Here, we found that D1 MSNs undergo fate switching to D2 MSNs in the absence of Zfp503. Furthermore, scRNA-seq revealed that the transcription factor Zfp503 affects the differentiation of these progenitor cells in the lateral ganglionic eminence (LGE). More importantly, we found that the transcription factors Sp8/9, which are required for the differentiation of D2 MSNs, are repressed by Zfp503. Finally, sustained Zfp503 expression in LGE progenitor cells promoted the D1 MSN identity and repressed the D2 MSN identity. Overall, our findings indicated that Zfp503 promotes the D1 MSN identity and represses the D2 MSN identity by regulating Sp8/9 expression during striatal MSN development.
Monitoring, evaluation, accountability, and learning (MEAL) in anticipatory action—earth observation as a game changer
Authors: Enenkel Markus , Dall Karen , Huyck Charles K. , McClain Shanna N. , Bell Veronica
Published: August 2022

For many decades, humanitarian assistance relied on emergency response, triggering both funding and operational activities only after disaster impacts had been recorded. In recent years, many humanitarian actors have joined forces to complement traditional, reactive mechanisms with a forward-looking approach that can be activated before a disaster strikes. Anticipatory action (AA) uses forecasts of extreme weather events and combines them with risk information to identify and implement locally-led early actions with the goal of protecting lives and livelihoods more efficiently. AA is still a relatively new approach. Hence, monitoring, evaluation, accountability and learning (MEAL) is crucial to measure its effectiveness and adjust where necessary, as well as for (government) donors that want to see the added value of their investment maximized. However, evidence-based studies that investigate potential limitations and the exact impact pathway of AA at household level are time-consuming, costly, and therefore scarce. Satellite earth observation can become a game changer in AA by strengthening the evidence base via rapid, low-cost assessments. Both commercial and freely available satellite-derived data have reached an unprecedented level of quality, spatial, and temporal resolution. Simultaneously, there are major uncertainties regarding where, when, how, and under what conditions satellite data can support MEAL for AA at all. We argue that satellite data for an advanced MEAL framework should be considered already in the design phase of AA projects and that the translation of satellite data into actionable information will require a cross-cutting community of practice.
MAGI1 inhibits interferon signaling to promote influenza A infection
Authors: Wang Yin , Abe Jun-ichi , Chau Khanh M. , Wang Yongxing , Vu Hang Thi , Reddy Velatooru Loka , Gulraiz Fahad , Imanishi Masaki , Samanthapudi Venkata S. K. , Nguyen Minh T. H. , Ko Kyung Ae , Lee Ling-Ling , Thomas Tamlyn N. , Olmsted-Davis Elizabeth A. , Kotla Sivareddy , Fujiwara Keigi , Cooke John P. , Zhao Di , Evans Scott E. , Le Nhat-Tu
Published: August 2022

We have shown that membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1), a scaffold protein with six PSD95/DiscLarge/ZO-1 (PDZ) domains, is involved in the regulation of endothelial cell (EC) activation and atherogenesis in mice. In addition to causing acute respiratory disease, influenza A virus (IAV) infection plays an important role in atherogenesis and triggers acute coronary syndromes and fatal myocardial infarction. Therefore, the aim of this study is to investigate the function and regulation of MAGI1 in IAV-induced EC activation. Whereas, EC infection by IAV increases MAGI1 expression, MAGI1 depletion suppresses IAV infection, suggesting that the induction of MAGI1 may promote IAV infection. Treatment of ECs with oxidized low-density lipoprotein (OxLDL) increases MAGI1 expression and IAV infection, suggesting that MAGI1 is part of the mechanistic link between serum lipid levels and patient prognosis following IAV infection. Our microarray studies suggest that MAGI1-depleted ECs increase protein expression and signaling networks involve in interferon (IFN) production. Specifically, infection of MAGI1-null ECs with IAV upregulates expression of signal transducer and activator of transcription 1 (STAT1), interferon b1 (IFNb1), myxovirus resistance protein 1 (MX1) and 2′-5′-oligoadenylate synthetase 2 (OAS2), and activate STAT5. By contrast, MAGI1 overexpression inhibits Ifnb1 mRNA and MX1 expression, again supporting the pro-viral response mediated by MAGI1. MAGI1 depletion induces the expression of MX1 and virus suppression. The data suggests that IAV suppression by MAGI1 depletion may, in part, be due to MX1 induction. Lastly, interferon regulatory factor 3 (IRF3) translocates to the nucleus in the absence of IRF3 phosphorylation, and IRF3 SUMOylation is abolished in MAGI1-depleted ECs. The data suggests that MAGI1 inhibits IRF3 activation by maintaining IRF3 SUMOylation. In summary, IAV infection occurs in ECs in a MAGI1 expression-dependent manner by inhibiting anti-viral responses including STATs and IRF3 activation and subsequent MX1 induction, and MAGI1 plays a role in EC activation, and in upregulating a pro-viral response. Therefore, the inhibition of MAGI1 is a potential therapeutic target for IAV-induced cardiovascular disease.
Case report: Paravalvular regurgitation post transcatheter aortic valve replacement: When in doubt choose cardiac magnetic resonance
Authors: Hadley Michael B. , Prandi Francesca Romana , Barillà Francesco , Sharma Samin , Kini Annapoorna , Lerakis Stamatios
Published: August 2022

Paravalvular leak (PVL) is a common complication following transcatheter aortic valve replacement (TAVR). Significant PVL is associated with adverse prognosis, but may be challenging to assess accurately. We report the case of an 81-year-old man with shortness of breath 5 months post TAVR. Echocardiography classified PVL as either moderate or severe depending on the parameter utilized, while angiography found only mild PVL. Cardiac magnetic resonance allowed an exact quantification of regurgitant flow volume, classified as clinically and hemodynamically significant. This case highlights the role of multimodality imaging assessment including cardiac magnetic resonance for a more accurate assessment of PVL severity, especially when other imaging modalities show discordant results.
Incidence of coronary drug-eluting stent fracture: A systematic review and meta-analysis
Authors: Chen Yang , Li Dandan , Liao Yanhui , Yao Xiongda , Ruan Yuehua , Zou Kai , Liao Hanhui , Ding Jingwen , Qin Hao , Yu Zuozhong , Zhao Yuanbin , Hu Longlong , Yang Renqiang
Published: August 2022

Background

Reported evidence of coronary stent fracture (CSF) has increased in recent years. The purpose of this study was to determine reliable estimates of the overall incidence of CSF.

Methods and results

The MEDLINE, Embase and Cochrane databases were searched until March 18, 2022. Pooled estimates were acquired using random effects models. Meta-regression and subgroup analysis were used to explore sources of heterogeneity, and publication bias was evaluated by visual assessment of funnel plots and Egger’s test. Overall, 46 articles were included in this study. Estimates of CSF incidence were 5.5% [95% confidence interval (CI): 3.7–7.7%] among 39,953 patients based on 36 studies, 4.8% (95% CI: 3.1–6.8%) among 39,945 lesions based on 29 studies and 4.9% (95% CI: 2.5–9.4%) among 19,252 stents based on 8 studies. There has been an obvious increase in the incidence of CSF over the past two decades, and it seems that the duration of stent placement after stent implantation has no impact on incidence estimation.

Conclusion

The incidence of CSF was 5.5% among patients, 4.8% for lesions and 4.9% for stents and increased over the past 20 years. The duration of stent placement after stent implantation was found to have no impact on the incidence of CSF, but drug-eluting stent (DES) types and right coronary artery (RCA) lesions influenced the pooled incidence.

Systematic review registration

[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022311995], identifier [CRD42022311995].
Global research trends in atherosclerosis: A bibliometric and visualized study
Authors: Tian Wende , Zhang Tai , Wang Xinyi , Zhang Jie , Ju Jianqing , Xu Hao
Published: August 2022

Background

Increasing evidence has spurred a considerable evolution of concepts related to atherosclerosis, prompting the need to provide a comprehensive view of the growing literature. By retrieving publications in the Web of Science Core Collection (WoSCC) of Clarivate Analytics, we conducted a bibliometric analysis of the scientific literature on atherosclerosis to describe the research landscape.

Methods

A search was conducted of the WoSCC for articles and reviews serving exclusively as a source of information on atherosclerosis published between 2012 and 2022. Microsoft Excel 2019 was used to chart the annual productivity of research relevant to atherosclerosis. Through CiteSpace and VOSviewer, the most prolific countries or regions, authors, journals, and resource-, intellectual-, and knowledge-sharing in atherosclerosis research, as well as co-citation analysis of references and keywords, were analyzed.

Results

A total of 20,014 publications were retrieved. In terms of publications, the United States remains the most productive country (6,390, 31,93%). The most publications have been contributed by Johns Hopkins Univ (730, 3.65%). ALVARO ALONSO produced the most published works (171, 0.85%). With a betweenness centrality of 0.17, ERIN D MICHOS was the most influential author. The most prolific journal was identified as Atherosclerosis (893, 4.46%). Circulation received the most co-citations (14,939, 2.79%). Keywords with the ongoing strong citation bursts were “nucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome,” “short-chain fatty acids (SCFAs),” “exosome,” and “homeostasis,” etc.

Conclusion

The research on atherosclerosis is driven mostly by North America and Europe. Intensive research has focused on the link between inflammation and atherosclerosis, as well as its complications. Specifically, the NLRP3 inflammasome, interleukin-1β, gut microbiota and SCFAs, exosome, long non-coding RNAs, autophagy, and cellular senescence were described to be hot issues in the field.
Features of non-stenotic carotid plaque on computed tomographic angiography in patients with embolic stroke of undetermined source
Authors: Guo Danling , Lv Sangying , Wu Guanzuan , Li Haifeng , Wei Bo , Yang Jianfeng
Published: August 2022

Purpose

Embolic stroke of undetermined source (ESUS) is a subset of cryptogenic stroke constituting a large proportion of acute ischemic strokes. This study aimed to assess the features of non-stenotic carotid plaque (<50%) on computed tomographic angiography (CTA) and to evaluate the association between non-stenotic carotid plaque and ESUS.

Methods

From January 1 to December 31, 2019, a total of 60 consecutive patients with primary unilateral ESUS and <50% carotid artery stenosis, as determined using screening ultrasonography, were hospitalized in the Department of Neurology of our hospital. All enrolled patients underwent CTA to determine the composition and morphological features of non-stenotic carotid plaques using consecutive sections in both carotid arteries. The features of these plaques with and without ipsilateral stroke in patients with ESUS were compared.

Results

Sixty ESUS images were included in the study, with 85 plaques. Forty-five (52.9%) of these plaques were ipsilateral and 40 (47.1%) were contralateral to the stroke. Compared to that of the contralateral plaque group, the maximum carotid plaque thickness and plaque length of the ipsilateral group were greater (2.1 mm vs. 1.5 mm, p = 0.03; 20.8 mm vs. 12.1 mm, p = 0.02); however, there were no significant differences in the degree of luminal stenosis, presence of soft plaque and calcified plaque, and the number of ulcers on the plaque surface between the two groups. Similarly, the number of plaques with thickness >3 mm in the ipsilateral group was greater than in the contralateral group (30 vs. 13, p = 0.01). A lipid core was more common in individuals with ipsilateral strokes than in those with contralateral strokes (19 vs. 7, p = 0.02). Regression analysis showed that plaque lipid core area was an independent risk factor for ESUS (odds ratio, 1.92; 95% confidence interval, 1.22–3.04; p = 0.03).

Conclusions

Non-stenotic carotid plaques could be an etiology of acute ischemic strokes classified as ESUS. The presence of a lipid core was a risk factor in individuals with non-stenotic carotid plaques.
Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy
Authors: Wang Jianru , Xie Shiyang , Cheng Yanling , Li Xiaohui , Chen Jian , Zhu Mingjun
Published: August 2022

Objective

Inflammation plays an important role in the pathophysiology of ischemic cardiomyopathy (ICM). We aimed to identify potential biomarkers of inflammation-related genes for ICM and build a model based on the potential biomarkers for the diagnosis of ICM.

Materials and methods

The microarray datasets and RNA-Sequencing datasets of human ICM were downloaded from the Gene Expression Omnibus database. We integrated 8 microarray datasets via the SVA package to screen the differentially expressed genes (DEGs) between ICM and non-failing control samples, then the differentially expressed inflammation-related genes (DEIRGs) were identified. The least absolute shrinkage and selection operator, support vector machine recursive feature elimination, and random forest were utilized to screen the potential diagnostic biomarkers from the DEIRGs. The potential biomarkers were validated in the RNA-Sequencing datasets and the functional experiment of the ICM rat, respectively. A nomogram was established based on the potential biomarkers and evaluated via the area under the receiver operating characteristic curve (AUC), calibration curve, decision curve analysis (DCA), and Clinical impact curve (CIC).

Results

64 DEGs and 19 DEIRGs were identified, respectively. 5 potential biomarkers (SERPINA3, FCN3, PTN, CD163, and SCUBE2) were ultimately selected. The validation results showed that each of these five potential biomarkers showed good discriminant power for ICM, and their expression trends were consistent with the bioinformatics results. The results of AUC, calibration curve, DCA, and CIC showed that the nomogram demonstrated good performance, calibration, and clinical utility.

Conclusion

SERPINA3, FCN3, PTN, CD163, and SCUBE2 were identified as potential biomarkers associated with the inflammatory response to ICM. The proposed nomogram could potentially provide clinicians with a helpful tool to the diagnosis and treatment of ICM from an inflammatory perspective.
The regulatory role of pioneer factors during cardiovascular lineage specification – A mini review
Authors: Sierra-Pagan Javier E. , Garry Daniel J.
Published: August 2022

Cardiovascular disease (CVD) remains the number one cause of death worldwide. Ischemic heart disease contributes to heart failure and has considerable morbidity and mortality. Therefore, alternative therapeutic strategies are urgently needed. One class of epigenetic regulators known as pioneer factors has emerged as an important tool for the development of regenerative therapies for the treatment of CVD. Pioneer factors bind closed chromatin and remodel it to drive lineage specification. Here, we review pioneer factors within the cardiovascular lineage, particularly during development and reprogramming and highlight the implications this field of research has for the future development of cardiac specific regenerative therapies.
Study on Stability Control of Gob-Side Entry Retaining Structure Without Filling Wall in Hard Roof
Authors: Jing-kui Long , Chao-xin Qi , Zuo-yong Cao , Hong Lan , Wen-kai Yu
Published: August 2022

In view of the deformation and instability law of hard roof without side filling retaining roadway, based on the systematic construction and analysis of the force and bearing model of roadway retaining structure, this article proposes the control mechanical model and calculation method of roadway retaining, which takes the anchor roof beam and the key block above to form the cantilever beam together, with the anchor solid coal side as the foundation support. The research and practice show that under the condition of hard roof, the mechanical connection between the roof of gob-side entry retaining and the roof of mining face can be effectively cut off so as to improve the structural configuration and mechanical properties of the lateral roof of gob-side entry retaining and the key blocks above, and reduce the damage of upper strata subsidence and goaf roof collapse to the roof of roadway. Then, through strengthening by anchor to significantly enhance solid coal side, bearing capacity of anchor roof beam, so they can share the upper strata caused by the load and deflection of mining influence, in addition, the roof bolting, reinforcement of waste rock bolting supporting role can better improve the structure for stability, adaptability and engineering applicability, this method is successfully applied in engineering practice. It is worthy of further research and application.
Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass
Authors: Liang Yuan , Yu Ruili , He Rui , Sun Lijun , Luo Chao , Feng Lu , Chen Hong , Yin Yue , Zhang Weizhen
Published: August 2022

Objective

Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes to weight reduction, and glycemic and lipid control after Roux-en-Y gastric bypass (RYGB).

Design

Four-week-old WT and Ghrl-TSC1-/- mice were fed high fat diet for 12 weeks before surgery, and continued to be on the same diet for 3 weeks after surgery. Body weight, food intake, glycemic and lipid metabolism were analyzed before and after surgery.

Results

Gastric and circulating ghrelin was significantly increased in mice with RYGB surgery. Hypoghrelinemia elicited by deletion of TSC1 to activate mTOR signaling in gastric X/A like cells demonstrated no effect on weight reduction, glycemic and lipid control induced by Roux-en-Y gastric bypass surgery.

Conclusion

Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass.
Association of gestational hypertension and preeclampsia with offspring adiposity: A systematic review and meta-analysis
Authors: Yan Shiyu , Lyu Jinlang , Liu Zheng , Zhou Shuang , Ji Yuelong , Wang Haijun
Published: August 2022

Background

The association of gestational hypertension (GH) and preeclampsia (PE) with offspring adiposity outcomes had controversial results in different studies.

Objective

We conducted a systematic review and meta-analysis to evaluate the relationship between maternal GH/PE and offspring adiposity outcomes.

Search strategy

Studies were identified in PubMed, Embase, and Cochrane databases, with keywords including “gestational hypertension”, “preeclampsia”, “offspring”, “weight”, “cohort study”, etc., without year restriction. This study was registered with PROSPERO, CRD42022292084.

Selection criteria

We set the selection criteria for six aspects: population, outcome, time frame, study design, and availability. For the studies included in the meta-analysis, we required the potential confounders in these studies have been adjusted.

Data collection and analysis

Two reviewers independently evaluated the data from the included studies. The meta-analyses included mean differences, regression coefficients, and corresponding 95% confidence intervals. Results were performed using RevMan software (version 5.4; Cochrane Collaboration). Heterogeneity among the included studies was assessed using the I2 statistic.

Main results

A total of 16 studies were included in our review, 15 of which were evaluated as high quality. In all offspring, during the early life (28 days-36 months), GH/PE exposure was found to be not or inversely associated with offspring obesity, then become positively associated at larger ages (3-19 years old). In offspring with adverse birth outcomes, the maternal GH/PE-exposed group had a lower weight in the short term (28 days to 18 months), but there was a trend of rapid weight gain as they grew older, compared with the non-exposed group. The meta-analysis showed that the BMI of the female offspring in the maternal PE-exposed group was significantly higher than that of the non-exposed offspring (MD=1.04, 95% CI: 0.67~1.42, P < 0.05).

Conclusions

The systematic review suggested that maternal exposure to de novo hypertension disorders of pregnancy (HDP) was associated with obesity in offspring, extending from early childhood to adolescence. The meta-analysis showed that PE was associated with higher BMI in female offspring. More studies are needed to conduct stratified analyses by PE/GH, the severity of HDP, or gender.

Systematic review registration

PROSPERO, identifier CRD42022292084.
Blood hemoglobin A1c might predict adverse differences in heart rate variability in a diabetic population: Evidence from the Midlife in the United States (MIDUS) study
Authors: Huang Ying , Chen Hong , Hu Dongxia , Wan Rong
Published: August 2022

Background

Cardiac autonomic neuropathy in population with diabetes mellitus (DM) is frequent and linked with high risk of cardiovascular mortality. However, studies on whether blood hemoglobin A1c (HbA1c) levels are related to adverse differences in heart rate variability (HRV) in individuals with DM are scarce.

Aim

We aimed to investigate the association of blood HbA1c levels with adverse differences in HRV, which is an indicator of cardiac autonomic control, in adult individuals with and without DM.

Methods

Data were collected from the Midlife in the United States (MIDUS) study, and 928 individuals were analyzed for the relationship between blood HbA1c levels and HRV through a cross-sectional analysis.

Results

Participants with DM had significantly higher HRV than those without DM. The smooth curve suggested inverse relationships between blood HbA1c levels and HF- and LF-HRV seen in participants with DM but not in those without DM after controlling for all covariates (age, sex, BMI, smoking, number of drinking years and exercise). Furthermore, linear regression analysis demonstrated that elevated blood HbA1c levels did contribute to adverse differences in HF-HRV (Sβ= -0.118; 95% CI -0.208, -0.027; P=0.012) and LF-HRV (Sβ= -0.097; 95% CI -0.177, -0.017; P=0.019) after controlling for these covariates in participants with DM, while in participants without DM, blood HbA1c was not significantly related to adverse differences in HF-HRV (Sβ=0.095; 95% CI -0.059, 0.248; P=0.228) or LF-HRV (Sβ=0.043; 95% CI -0.103, 0.189; P=0.565). DM has a significant modifying effect on associations between blood HbA1c and adverse differences in HF-HRV (P for interaction=0.019) and LF-HRV (P for interaction=0.029).

Conclusions

We reported strong evidence that elevated blood levels of HbA1c were associated with adverse differences in HRV in the diabetic population but not in the nondiabetic population. This finding supported that long-term hyperglycemia is related to autonomic nerve injury in the diabetic population. Blood HbA1c might be a good indicator of cardiac autonomic neuropathy.
Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts
Authors: Kulkarni Sudhir A. , Deshpande Supreet K. , Rastogi Ashu
Published: August 2022

Aims/Objectives

Wound healing in people with diabetes is delayed secondary to impaired nitric oxide generation, advanced glycation end products (AGE), and poor migration of epithelial cells. We developed a novel topical esmolol hydrochloride (Galnobax) and assessed its efficacy for wound healing in streptozocin-induced diabetic hairless rat.

Methods

All experiments were performed at an animal laboratory and tertiary-care research facility. Ex vivo aldose reductase inhibition was assessed from enzymes obtained from a bacterial culture (spectrophotometer), sorbitol content in homogenized red blood cells, and AGE in glucose and bovine serum by fluorometry following the addition of esmolol in varying concentrations. A scratch assay of human fibroblasts, endothelial cells, and keratinocytes was assessed under a high-glucose environment and after esmolol by phase-contrast microscopy. The efficacy evaluation of the topical application of Galnobax (14 and 20%) or vehicle was conducted in streptozotocin-induced diabetic hairless rats, and endogenous nitrite and hydroxyproline from homogenized wound tissue were measured along with pharmacokinetic and dermal toxicity in Hanford miniature swine.

Results

Esmolol inhibited the formation of sorbitol by 59% in erythrocytes in comparison to glucose-induced sorbitol levels. AGE generation in bovine serum albumin was reduced at 1 mM esmolol concentrations (2.6 ± 1.7) compared with control (p < 0.05) and similar to that of diclofenac (2.5 ± 1.3). Esmolol at 1 and 10 µM enhanced the migration of fibroblasts, epithelial cells, and keratinocytes compared with control. The nitric oxide levels (day 7) were 44 and 112% higher with Galnobax (14%) than those of the diabetic group (p < 0.05) and the vehicle control group (p < 0.05), respectively. The days 7 and 14 hydroxyproline in the wound was higher by 22 and 44% following Galnobax (14%) compared with the diabetic and vehicle control groups. The wound area exhibited better reduction with Galnobax at 14% up to day 10 follow-up compared with the controls. The pharmacokinetic and dermal toxicity in miniature swine suggested no significant adverse event with Galnobax.

Conclusions

Topical esmolol hydrochloride is a novel, safe, and effective treatment modality that acts through pleotropic mechanisms to hasten wound healing in diabetes.
Causal relationships of obesity on musculoskeletal chronic pain: A two-sample Mendelian randomization study
Authors: Chen Xiaoqing , Tang Haifeng , Lin Jinding , Zeng Rongdong
Published: August 2022

Background

The association between obesity and musculoskeletal chronic pain has attracted much attention these days; however, the causal relationship between them is uncertain. Hence, this study performed a Mendelian randomization (MR) analysis to investigate the causal effects of body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) on knee pain, hip pain, and back pain.

Materials and methods

The summary data for obesity and musculoskeletal chronic pain came from the genome-wide association study datasets. Significant and independent (p < 5 × 10−8; r2 < 0.001, kb = 10,000) single-nucleotide polymorphisms were extracted for MR analysis. The inverse variance weighted (IVW) and other methods were used for MR analysis, while sensitivity analyses were conducted to test the reliability and stability.

Results

The positive causal effects of BMI on knee pain (odds ratio (OR) = 1.049; 95% CI: 1.034 to 1.063; p = 9.88 × 10−12), hip pain (OR = 1.034; 95% CI: 1.024 to 1.044; p = 1.38 × 10−12), and back pain (OR = 1.022; 95% CI: 1.007 to 1.038; p = 0.004) were observed. WC and HC were also positively associated with knee pain (WC: OR = 1.057; 95% CI: 1.041 to 1.072; p = 1.54 × 10−13; HC: OR = 1.034; 95% CI: 1.017 to 1.052; p = 1.32 × 10−4) and hip pain (WC: OR = 1.031; 95% CI: 1.020 to 1.042; p = 2.61 × 10−8; HC: OR = 1.027; 95% CI: 1.018 to 1.035; p = 5.48 × 10−10) but not back pain. No causal relationship was found between WHR and musculoskeletal chronic pain. The results were robust according to sensitivity tests.

Conclusions

This study revealed that BMI was positively related to knee, hip, and back pain and that WC and HC were positively associated with knee and hip pain, while WHR was not related to any type of musculoskeletal chronic pain.
Xanthan gum as a water-based binder for P3-Na2/3Ni1/3Mn2/3O2
Authors: Zilinskaite Silvija , Reeves-McLaren Nik , Boston Rebecca
Published: August 2022

P3-Na2/3Ni1/3Mn2/3O2 (P3-NNM) is a promising cathode material for Na-ion batteries, although large volume expansions during cycling mean that challenges around suitable binders still remain. This study reports the use of xanthan gum as a water-soluble, easy to handle, and sustainable biopolymer binder in conjunction with a P3-Na2/3Ni1/3Mn2/3O2-positive electrode material. The conditions for recovering pristine P3-NNM powders, following water-based processing, are established, and the electrochemical performance of cells prepared using the xanthan gum binder are compared to the more traditional polyvinylidene fluoride. Comparable discharge capacities are observed regardless of the binder choice, at ca. 115 mA h g−1 (77 mAh g−1 after 50 cycles; 0.1 C between 2.0 and 4.2 V). The xanthan gum binder cells also show a similar rate capability and slightly higher capacities at faster c-rates vs. polyvinylidene fluoride, making xanthan gum a viable alternative to the traditional organic binders for water-stable cathode materials.
PV array reconfiguration with electrical energy storage system for power system frequency regulation
Authors: Zhou Jun , Liu Chong , Li Kun
Published: August 2022

In this work, a novel PV station participating FR technique based on PV array reconfiguration and battery energy storage system (BESS) is put forward. Through the PV array reconfiguration under Partial shading condition, photovoltaic (PV) system can adjust the output power according to the power dispatch instruction. And with the help of BESS, The PV station can achieve continuous power output. Specifically, a joint PV energy storage system model combining profit maximization and power deviation minimization is established. In order to two conflicting goals simultaneously, multi-objective golden eagle optimizer and improved ideal point decision making method are applied. And Lagrange function is given to determine the weight coefficients of each objective more fairly. Two cases are designed and tested. In the high frequency response simulation test, the profit is increased by 8.4% and the power deviation from FR signal is decreased by 19.98%; meanwhile the profit is increased by 10.07% and power deviation is decreased by 67.69% in the low frequency response test. Therefore, the simulation results verify that the proposed method contributes to the frequency response of PV station.
Is green and sustainable technological innovation a potential driver of environmental performance? an empirical investigation across the ASEAN region
Authors: Rehman Shazia , Holý Ondřej
Published: August 2022

Environmental degradation is a significant concern that jeopardizes global sustainable production and consumption. In this instance, ASEAN (Association of South-East Asian Nations) has contributed to a considerable amount of carbon dioxide (CO2) emissions throughout the modernization phase. However, there is a paucity of information within this region on the non-linear impact of transitions in green and sustainable technological innovation on CO2 emissions. In response, the present work endeavors to bridge the existing research gap by examining the asymmetrical and periodic interactions between green and sustainable technological innovation and CO2 emissions by employing cross-sectional time series data of 7-ASEAN economies over the period 1990 to 2017. The co-integrating connections between the specified parameters were established using the Wester-Lund cointegration technique. Further, the Cross-Sectionally Augmented Autoregressive Distributed Lag estimator revealed that negative disruptions in green and sustainable technological innovation lead to CO2 emissions during downturns. Secondarily, the findings confirmed positive surges in green and sustainable technological innovation minimize CO2 emissions during times of economic expansion. Also, as compared to foreign direct investment, current statistics indicate that renewable energy utilization seems to have a substantial impact on reducing carbon emissions. Besides, the robustness analysis corroborated the uniformity and validity of the given outcomes. Consequently, the outcomes divulged a counter-cyclical interaction between green and sustainable technological innovation and CO2 emissions.
What affects China’s high-tech industry land misallocation: Government behavior or enterprise behavior?
Authors: Han Lu , Zhou Liping , Bao Haijun , Zeng Xin , Taghizadeh-Hesary Farhad
Published: August 2022

The high-tech industry belongs to the core strategic national development category and is essential in promoting social future economic growth and scientific and technological progress. This paper constructs a theoretical framework for high-tech industry land misallocation based on the four-level institutional analysis method. The study selects Zhejiang Province of China as the research area. It uses the literature research method and multiple regression analysis methods to analyze the root causes and influence mechanism of land misallocation for the high-tech industry. The research shows that the land-use support policies for the high-tech industry can effectively alleviate the misallocation of land factors. In contrast, the government’s improper financial support measures and tax incentives increase the degree of land misallocation in the high-tech industry. The higher the R&D expenditure-to-income ratio and profitability, the lesser the land misallocation in the high-tech industry. Government behavior and enterprise behavior impact land misallocation in the high-tech industry, but government behavior has a major impact. Therefore, the government, enterprises, and the market should adopt an integrated strategy to reduce excessive government intervention in land resource allocation, allowing the market to play a decisive role in resource allocation, and stimulate the vitality of enterprise R&D and innovation. This study helps to reveal the deep motivation of land misallocation for high-tech industry and provides practical guidance for optimizing the high-tech industrial land allocation and promoting high-quality industrial development.