bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of the Integration-Interconnection of Introduction to Islamic Studies at the Sociology Study Program of UIN Sunan Kalijaga Yogyakarta
Authors: Rohmah Elvi Tri Astuti , Suryana Yayan , Sibawaihi Sibawaihi
Published: November 2022

This paper discusses the application of interconnection integration in Introduction to Islamic Studies in the Department of Sociology at the State Islamic University of Sunan Kalijaga Yogyakarta. The purpose of this study is to find out how an educator / lecturer in dealing with students who do not have basic Islamic religion at the previous level of education. In addition to applying in learning, interconnection integration is also applied in lecture material. This research uses descriptive qualitative research. Research data obtained from observations, journals, books, and opinions related to the integration of interconnections and Islamic studies. The result of the research is that educators always recommend students to include concrete examples in each material according to the specified approach. In each of the given material themes, an approach is always used, which integrates science and religion. After learning is complete, students are also given the task of writing a resume of at least two paragraphs which contains the core of the discussion in each meeting. Integration of interconnections is important to always be developed in any type of science, in order to produce updates in the future.
PAI Teacher's Strategy In Developing Student's Emotional Intelligence
Authors: Fadilah Lutfi , Wijaya Adi
Published: November 2022

The type of this research is qualitative approach, with the background of MAN 1 East Lampung. The methods used in collecting data are interviews, observation, and dokumentation. Data analysis was used the Psychology and Islamic Education approach, by doing data reduction, data presentation, and conclusion drawing. Data validity was tested by triangulation of techniques and sources. The results of this study indicate that strategies used by PAI teachers in developing emotional intelligence of MAN 1 East Lampung students based on aspects of emotional intelligence expressed by Daniel Goleman such as the ability to recognize self-awareness, self-regulation, self-motivation, empathy and social skills, namely by conducting training, applying learning methods, and humanistic approaches. In addition, teachers develop emotional intelligence through Islamic teachings to shape student morals, such as habituation education, spiritual training with worship (riyadah), and efforts to refrain from lust (mujahadah).
The Role of Islamic Boarding Schools in Instilling Deradicalization Values
Authors: Alfarisi Salman , Q Ikhwan Aziz , Khoiriyah Khoiriyah
Published: November 2022

This research focuses on the ethics and morals of educators and learners in Islamic education. The ethics of educators and students in Islam turned out to be gradually starting to change, economic values gradually began to enter, so that what is happening now is that there are many problems that occur in the world of education such as the crisis of ethics from both educators and students. This study aims to examine how the ethics of educators and students in the perspective of Islamic education. The method in this research is a literature method that refers to books, esklopedia, and scientific articles. The conclusions in this study are the ethics that must be possessed by educators in the Islamic education perspective, including: teachers must have a broader understanding, be professional, love their students, provide the right to education in a fair, honest, sincere manner when dealing with diverse student situations. The ethics that must be possessed by peseta didik in the perspective of Islamic education are: having the intention to study because of Allah SWT, strong, sincere and steadfast in studying.
The Effect of Emotional Social Development on Physical Motor Development in Early Childhood
Authors: Mayra Zara , Maulana Muhammad Nizar , Kushendar Kushendar
Published: November 2022

Social development is the development of behavior in children where children are asked to adapt to the rules that apply in the community. Emotional development will affect how children's attitudes and behavior towards the surrounding environment. so that the role of parents, peers, teachers and those around them is very important in supporting children's development, especially at an early age. This article used library reaserch method, from book, theory of pshycosocial and finding figure social emotional development. Finding of this discustions according to the literature review conducted, it was found that at an early age, which is around 4 to 6 years, is the most appropriate age to shape children's character by stimulating positive things to children and reducing the emergence of negative attitudes in children. Therefore, children at an early age need supervision, especially in bringing up the right stimulus to receive stimulation that is quite good, directed, and driven to the level of growth and development.
Online Learning: Strategies to Improve Critical Thinking Skills on PAI Learning In School
Authors: Wicaksono Yanuar , Fitri Agus Zaenul , Aziz Abd.
Published: November 2022

This study aims to explain the implementation of online learning and teacher strategies in improving students' critical thinking skills in PAI subjects at SMPN 1 Sumbergempol Tulungagung and SMPN 3 Tulungagung. The research method is qualitative. The research approach is phenomenological. The type of research is field research. The research design was a multi-site study. Data were obtained by in-depth interviews, participant observation, and documentation. The research data is then organized into categories, described into units, synthesized, arranged into patterns, selected priority data, and made conclusions so that they are easy to understand. The results showed that WhatsApp, Telegram, Google Classroom, Zoom, Google Meet, One Drive, Google Form, and Microsoft Office 365 teachers were integrated. The strategy used by the teacher is to design learning and implementation of learning that directs critical thinking. The teacher sharpens thinking levels from C1, C2,3 to C4, C5, C6. The task given is to find material from the internet and analyze it. Students will use critical, analytical, comparative, selective and creative reasoning.
The Five Main Values of Strengthening Character Education (PPK) in Umar bin Khattab
Authors: Pratama Yoga Anjas
Published: November 2022

The value of character education is standards of human behavior in the life of society and the state. Ministry of Education and Culture of the Republic of Indonesia has declared five main values of strengthening character education (PPK) as the axis of education, namely: religious, nationalist, independent, mutual cooperation and integrity. These five values basically exist in Umar bin Khattab. For that in this research will be studied in more depth related the five main values of character education in Umar bin Khattab. This research is a library research conducted by means of descriptive analysis to data sources, in the form of: articles, books and related documents. The result of this research is that there are five values of character education in Umar bin Khattab, consist of: (1) Religious: attitude of fear and obedience to Allah's commands, love of nature and tolerance (2) Nationalist: excellent and achievers, appreciate achievements, obey the law and care about social (3) Independent: disciplined, hardworking and brave (4) Mutual cooperation: cooperation, helping each other and likes to consult (5) Integrity: love of truth, love of peace, fair, honest, responsible, gentle and generous.
Pesantren and Surau as Forms of Modern Islamic Education Traditions in Indonesia
Authors: Heni Yuliana Wati  , Rina Mida Hayati  , Dika Tripitasari
Published: November 2022

Pesantren is a historical tradition of Islamic education in Indonesia which originated from ancient times and it has been proven that in addition to educating about the faith and piety of the students (santri) and also educating about noble character. Surau is a place for traditional ceremonies and then gradually becomes a place of worship and as a gathering place for young people to learn to explore skills and various knowledges. Surau and Islamic boarding schools in Indonesia must be maintained and developed for their existence as one of the institutions whose presence is in the middle of the life of the wider community. After being able to fight the invaders and then Indonesia became independent, the pesantren that had been established filled independence with things that were full of benefits without having to be afraid of the invaders. The tradition and modernization of Islamic education in Indonesia is not just a boarding school, but there are also mosques, madrasas and halls.
MEMBANGUN MODERASI BERAGAMA MELALUI BARIKAN PUNDEN DI DESA TERNADI
Authors: Mu'ayyadah Mu'ayyadah , Fatmawati Noor , M Nur Dany Miftah
Published: November 2022

The purpose of this study was to describe the punden in Ternadi Village, namely Sunan Kaliyetno, Petilasan Mbah Njokowono, Nyai Soemarsih, Nyai Satirah, and Kyai Jenggot in Ternadi Village. Second, is to describe the values ​​of moderation which consist of four things, namely the value of local wisdom, the value of tolerance, the value of national insight, and the value of anti-violence. The third is to describe the application of religious moderation through the punden punden Sunan Kaliyetno, Petilasan Mbah Njokowono, Nyai Soemarsih, Nyai Satirah, and Kyai Jenggot. The data collection technique used descriptive qualitative methods which included interviews, observations, and documentation. The data analysis uses the method from Miles Huberman, namely collecting data, selecting data, presenting data, and drawing conclusions/interpretations. The results of the research obtained are the practice of religious moderation carried out by the Ternadi community through local wisdom in the form of punden Sunan Kaliyetno, Petilasan Mbah Njokowono, Nyai Soemarsih, Nyai Satirah, and Kyai Jenggot. The conclusion is that the punden at Ternadi can be an application of religious moderation so as to strengthen brotherhood among the community.
Teacher Guidance in the Digitalization Era: Efforts to Improve Student Achievement by Strengthening Online Sourced Learning Materials
Authors: Abd. Basir  , Salamah  , Suriagiri  , Mudhiah  , Mohammad Ahmad Bani Amer
Published: November 2022

The article aimed to analyze the teacher guidance in the digitalization era: an effort to improve student achievement by strengthening online-sourced learning materials at Madrasah Aliyah Negeri (MAN) Insan Cendikia Pelaihari Banjarmasin. Through semi-structured interviews with several teacher councils, the researchers have received many vital inputs regarding the dedication of teachers in guiding students to learn applications in the digital era in the distance learning situation.  The researchers used a phenomenological approach to understand how teachers monitor online learning activities in the current era of technology. The result showed that the teachers was able to get the students care and using learning resources in various forms of application. The dedication of the teachers and the students in Madrasah Aliyah teachers from Pelaihari Banjarmasin has become strengthening in online sourced learning materials. The stduents has changed to get learning achievement to be better result. Hopefully, these findings help developing educational studies in the current era of technology. Keywords: Online Learning Materials, Improve Students Achievement, Online Learning
Analysis of Online Teaching At the Time of The Pandemic at Mi Miftahul Ulum Tongas
Authors: Soliha Imro Atus
Published: November 2022

Abstract

This study aims to analyze how the learning process during the COVID-19 pandemic is carried out on the network (Daring), and also review the factors in the learning process at MI (Madrasah Ibtidaiyah) Miftahul Ulum Tongas. This research was held in October 2020. The Researcher used qualitative research with phenomenological design. Questionnaires and interviews were used in collecting the data. The subjects used in the study were several teachers at MI Miftahul  Ulum  Tongas. The results of this study showed that learning at MI Miftahul Ulum using WhatsApp group application and google form. Offline learning is also applied while adhering to health protocols. The supporting factors of online learning at MI Miftahul Ulum Togas are gadgets, laptops, internet quotas, and books. While the inhibiting factors of online learning were: teachers can not explain maximally, motivation of learners, and economic factors.
Thoshihiko Izutsu’s Descriptive Significance in the Story of Maria in The Qur’an and His Approuch Techniques | Al-dala>lah Al-Was}fiyah li Tusyihi@ku> i>zutsu> ‘an Qis}s}oti Maryam Fi> Al-Qura>n Wa Taqniyatu Madkholiha>
Authors: Amalia Dian Risky , Istianah Asna , Mushodiq M Agus , Pratiwi Bety Dwi
Published: November 2022

In Toshihiko Izutsu's book entitled Ethico-Religious Concept in the Qur'an, he states that his semantic study contains three parts. explain the methodological principles of semantic analysis, the positive and negative relationship of pre-Islamic tribal moral rules with Islamic Qur'anic ethics and the consistent application of the methodological rules that have been described. Basically, this thesis concludes that the study of the meaning of the Qur'an must be examined critically because the Qur'an presents its contents globally, so a critical study is needed to understand the message it contains. This research is a type of qualitative literature. The method used is to search for all Maryam words in the Qur'an and then group them after being divided into several groups, This research is qualitative literature. The method used is to search for all Maryam words in the Qur'an and then group them after being divided into several groups. The results of this study indicate that Toshihiko Izutsu's semantic approach is more effective than relying on translated text. This study also tries to apply this approach to Arabic learning, especially in meanings such as translation skills and Reading Comprehension. This approach seems suitable to be applied in order to minimize errors experienced by students in interpreting reading texts.

Keywords: Story of Maryam, Semantics of Toshihiko Izutsu, influence and application.
The Effect of Flipped Classroom Learning in Enhancing Mathematics Learning Outcomes of Blind Students During The Pandemic
Authors: Fatimah Oryza Lisativani , Adiningsih Rara , Lubis Fitriyana Desynta , Fathani Abdul Halim
Published: November 2022

This study aims to analyze the effect of Flipped Classroom learning on the mathematics learning outcomes of blind students during the Covid-19 pandemic. This type of research is Quasi-Experimentals with Nonequivalent Control Group Designs. The population used in this research is the blind students of class V and class VI of SLBN ABD Kedungkandang Malang city with 12 students. Samples were taken using a saturated sampling technique. The experimental class uses the Flipped Classroom learning model for class VI students, and the control class uses a direct learning model as a comparison, namely for class V students. The data results show Normal and Homogeneous with the resulting significance value > 0.05. Then the final test is the independent sample t-test to determine whether there is a difference in the average of the two unpaired samples from the data. Depending on the first decision by observing the column value Sig.t count (2-tailed) or P-value, required if the value of Sig. t-count 0.05, then H0 is accepted, and if the value of Sig. t-count 0.05, then H0 is rejected. From the second decision, H0 is rejected, and H0 is not enough to be accepted. The results showed that learning mathematics with the Flipped Classroom learning model for blind students in the covid-19 pandemic had a more positive effect than the results of learning mathematics in a direct learning class or without any treatment with the Flipped Classroom model.
Development of Local Wisdom Realistic Mathematics Education Based Students Activity Sheet on Students' Mathematics Problem Solving Ability
Authors: Ladona Elvin Ervi , Caswita Caswita , Ambrita Alben
Published: November 2022

The selection of Student Activity Sheets (LKPD) is carried out to direct students' independent learning to help them understand the learning material. With local wisdom RME-based LKPD, students have a relatively firm understanding of mathematical problems. The purpose of this study is to develop LKPD products based on Realistic Mathematical Education (RME) with local wisdom of DAM Raman and Capit Urang Metro tourism objects on KPK and FPB materials that are suitable for use and are effective in mathematical problem-solving abilities. This type of research is research and development research and development (RnD) Borg and Gall. The population of this study was fourth-grade elementary/MI students in the Madrasah Working Group (KKM) 2 Metro City. The sampling technique used the class IV purposive sample technique at MINU Metro. The results of this study indicate that the development of RME-based LKPD products with local wisdom is declared feasible based on the results of validation from experts and is practical to use in terms of attractiveness, convenience, and usefulness. RME-based worksheets are effectively used in students' mathematical problem-solving abilities.
PENGARUH KOMITMEN DAN TURNOVER INTENTION TERHADAP KINERJA KARYAWAN (STUDY KASUS PERUSAHAAN YANG BERADA DI LAMPUNG)
Authors: Bakhtiar Yusuf Muhamad , Jamal Rio Syukron , Firdaus Sandy , Sanjaya Vicky F
Published: November 2022

This study aims to examine the effect of commitment and intention to turnover on the performance of existing employees in Lampung. The method used is to use a test questionnaire distributed through online media. The sample of this study may be 81 respondents. The statistical test was carried out using Structural Equation Modeling based on SmartPLS 3. The validity test used the loading factor value. While the reliability test used Cronbach's alpha value, composite reliability and Average Variance Extracted (AVE). From the results of hypothesis testing, commitment to employee performance has a positive and significant effect. Meanwhile, Turnover Intention has a negative and insignificant effect on employee performance).
PENGARUH KEPEMIMPINAN ISLAMI TERHADAP KINERJA KARYAWAN PADA PERUSAHAAN MULTIFINANCE SYARI’AH DI PROVINSI LAMPUNG
Authors: Efrina Lisa
Published: November 2022

This study aims to investigate the influence of Islamic work ethics and organizational culture on employee performance at Shari’ah Multifinance Lampung. The study used descriptive research with quantitative approach. The samples were done nonprobability sampling with purposive sampling method. The result show that the application of Islamic leadership positively influenced on employee performance. its known from the t test value (8.157) more than t table (2.040).
Consequências do abuso de substâncias psicoativas na perspectiva de mulheres usuárias
Authors: Soccol Keity Laís Siepmann , Terra Marlene Gomes , Tisott Zaira Letícia , Souza Martha Helena Teixeira de , Ferreira Carla Lizandra de Lima , Silveira Andressa da , Dutra Patricia Cristiane da Costa , Soliz Paola Piovenzano de , Marchiori Mara Regina Caino Teixeira , Siqueira Daiana Foggiato de
Published: November 2022

Objetivo: Compreender quais são as consequências do abuso de substâncias psicoativas na perspectiva de mulheres usuárias de um Centro de Atenção Psicossocial álcool e drogas. Métodos: Pesquisa qualitativa, do tipo descritiva e exploratória, realizada em um Centro de Atenção Psicossocial, localizado em um município do estado do Rio Grande do Sul, com 20 mulheres usuárias de substâncias psicoativas. Os dados foram coletados por meio de entrevistas abertas, entre fevereiro a maio de 2017. As entrevistas foram encerradas no momento em que houve a saturação de dados, e analisadas pela técnica de Análise Temática. Resultados: As consequências do abuso de substâncias psicoativas fazem com que as mulheres tenham perdas de emprego, dificuldades na manutenção das relações familiares, fiquem expostas à risco de violência e acidentes de trânsito, bem como ocasiona diversos danos à saúde das mulheres. Conclusão: O estudo sinaliza a importância de um cuidado centrado nas demandas sociais e de saúde e, que levem em consideração as diferenças de gênero ao assistir as mulheres.
Trabalho noturno e as repercussões na saúde dos trabalhadores de enfermagem
Authors: Sousa Maria Talissa Oliveira de , Poty Nalma Alexandra Rocha de Carvalho , Morais Fernanda Ferreira de , Poty Josefa Angélica Cerqueira , Cunha Barbara de Jesus , Faray Carina Santos , Bezerra Cristiane Véras , Caminha Jéssica de Moura , Santos Shelma Feitosa dos , Santana Marta Silva de
Published: November 2022

Objetivo: Descrever acerca do trabalho noturno e as repercussões na saúde dos trabalhadores de enfermagem. Revisão bibliográfica: Os trabalhos noturnos realizados por trabalhadores de enfermagem interferem na vida profissional e pessoal e podem acarretar doenças desde limitações físicas a psíquicas. Enfatiza-se a importância do descanso durante os plantões e após a chegada no domicílio para evitar distúrbios ansiosos e/ou depressivos, perda de sono, problemas com concentração, conflito emocional, aflição, psicose, problemas em relacionamentos interpessoais, irritação com excesso de preocupações, problemas para relaxar. O cansado ocasionado pela falta de sono pode representar risco de erros, acidentes e prejuízo para o paciente. É necessária compreensão dos gestores acerca dos prejuízos que os plantões noturnos trazem, para assim articularem estratégias para melhorar a qualidade de trabalho e vida desse público, sendo urgente estabelecer procedimentos destinados a minimizar erros na prática de trabalho intensivo dos serviços de saúde. Considerações finais: O trabalho noturno entre trabalhadores da enfermagem promove alterações na vida desse público, trazendo-lhes repercussões físicas, psicológica e sociais.
Diferenças sexuais a respostas vacinais: uma revisão narrativa
Authors: Nascimento Amanda Grazyella Fernandes , Costa Bárbara de Assis Macedo , Linhares Marielle Mendes , Oliveira Lucas Pereira , Souza Clarissa Leal Silva e
Published: November 2022

Objetivo: Analisar por meio de uma revisão narrativa as diferenças sexuais das respostas vacinais. Revisão bibliográfica: A vacina é usada em escala global com o intuito de prevenir casos graves de doenças imunoinfecciosas e garantir uma qualidade de vida a toda a população. Existem diversos tipos de vacinas que são eficazes contra patologias virais e bacterianas ofertadas em diferentes sistemas de saúde. Seu benefício é comprovado em diversos estudos e são poucos os efeitos adversos que podem ser geradas após a imunização. Sabe-se que ela pode se comportar diferentemente em variados fatores como sexo, idade, populações especiais e modulações genéticas que influenciam na capacidade de criar uma resposta imune adequada. Considerações finais: As reações imunológicas a vacinas em mulheres são mais robustas em algumas vacinas virais, e em alguns homens elas podem se manifestar diferente. O entendimento das diferentes reações às vacinas entre os sexos é de suma importância para a profissionais da saúde e futuros profissionais, uma vez que existe um aumento progressivo do medo e da descrença populacional em relação às vacinas e sua segurança.
Manejo e conduta da rabdomiólise: uma revisão de literatura
Authors: Almeida Maria Eduarda Gomes Walkoff de , Francisco Alison Losi , Sallum Beatriz Gamel , Santos Hiago Neves , Petrucci Luiza de Sant’ Anna , Cardinal Manuella dos Santos , Marques Melissa Alves Aires , Lopes Bruno Augusto
Published: November 2022

Objetivo: Revisar e apresentar conceitos básicos da rabdomiólise, aprofundando-se no manejo e conduta no setor de emergência. Revisão bibliográfica: A rabdomiólise é definida pela quebra do tecido muscular com liberação de enzimas intracelular na circulação sanguínea. Drogas que afetam os músculos como estatina, infecções, desequilíbrios eletrolíticos e trauma podem propiciar rabdomiólise. O quadro clínico varia conforme a gravidade do caso, grau e extensão da lesão muscular. A doença tem como principais sintomas: mialgia, miastenia, colúria e elevação de Creatina Quinase (CK). Como manejo inicial, faz-se necessário realizar uma reposição volêmica agressiva. A hipercalemia é a anormalidade eletrolítica com maior risco de vida nessa patologia, sua correção pode ser realizada pelo uso de insulina e glicose intravenosa. Caso o paciente desenvolva insuficiência renal aguda, devem ser tomadas medidas para controlar a sobrecarga. Por isso, deve-se considerar terapia de substituição renal. Considerações finais: A rabdomiólise caracteriza-se pela destruição muscular com liberação dos seus componentes na corrente sanguínea. Nesse sentido, torna-se necessário realizar a conduta adequada e precoce durante o manejo dessa doença na emergência, a fim de diminuir as chances de complicações graves e morte do paciente.
Persistence of symptoms after Covid-19 infection in Kerala
Authors: SREELAKSHMI P.R. , SIJI V.S. , GOPAN KARTHIKA , GOPINATH SANGEETHA , NAIR AMAL S.
Published: November 2022

Background

Persistence of symptoms following Covid-19 infection has now been recognized as an upcoming public health crisis. Understanding these persistent symptoms and quantifying them is vital in planning care for these patients. Studies from India estimating the magnitude of these persistent symptoms are scarce. We aimed to estimate the proportion of symptoms that persist among patients who have recovered from Covid-19 infection.

Methods

We conducted this descriptive study among 114 individuals after they recovered from Covid-19 infection. Participants diagnosed as Covid-positive at a tertiary care centre were included in the study. Data were collected from the participants through an online platform. Frequency and proportion of various persistent symptoms were estimated. Analysis was done using SPSS version 16.

Results

The mean (SD) age of the study participants was 35.5 (15.7) years. Women comprised 62.3% (n=71) of the population. Persistent symptoms were reported by 66 (57.9%; 95% CI 53.07–62.72) participants. The most common symptoms reported were fatigue (n=45, 39.5%) and joint pain (n=23, 20.2%). Those who required hospitalization for longer duration were found to be more associated with having persistent symptoms (p=0.018).

Conclusion

A sizable proportion of individuals had persistent symptoms after recovering from Covid-19 infection. Health facilities should be equipped to address these emerging issues.
The Role of Herbivore-induced Plant Volatiles in Trophic Interactions: The Swiss Connection
Authors: Turlings Ted C. J. , Degen Thomas
Published: November 2022

It is increasingly evident that plants actively respond to the threats and challenges that they come to face while growing. This is particularly manifested in the dynamic responses to insect herbivory, especially in terms of the volatile compounds that the attacked plants emit. Indeed, many plants respond to insect-inflicted damage with the synthesis and release of volatile organic compounds. These emissions, commonly referred to as herbivore-induced plant volatiles (HIPVs), play important roles in the interactions between the emitting plants and their biotic environment. The odorous signal can be picked up and exploited by various organisms: neighbouring plants, herbivores and their natural enemies, such as predators and parasitoid wasps. Coincidence or not, scientists currently working in Switzerland have made numerous key contributions to the work in this field. By highlighting their work, we attempt to give a somewhat historic overview of this field of research.
Oil from cress Nadezhda (Brassica rapa subsp. сampestris) in broiler chicken feed
Authors: Зарудный В.А.
Published: November 2022

Исследования проводились в Московской области в условиях филиала СГЦ «Загорское ЭПХ» в 2021–2022 годах. На четырёх группах цыплят-бройлеров кросса «Смена 9» в возрасте от 1 до 35 суток при клеточном содержании изучена возможность использования в комбикормах масла, полученного из сурепицы сорта Надежда, взамен подсолнечного масла. Для масла, полученного из семян сурепицы, характерно сравнительно низкое содержание насыщенных жирных кислот (5,59%). Масло сурепицы характеризуется сравнительно низким содержанием пальмитиновой и стеариновой жирных кислот. На долю этих двух кислот приходится всего 1,95%. Среди других особенностей масла, полученного из сурепицы нового сорта Надежда, следует указать на высокое содержание олеиновой кислоты (61,0%), выше, чем в подсолнечном масле, на 33,9% (Р ≤ 0,001). Установлено, что включение в комбикорма масла сурепицы в количестве 1,5 и 3,0% взамен подсолнечного масла позволило повысить живую массу бройлеров на 5,27 и 6,19%, снизить затраты корма на прирост 1 кг живой массы на 1,99 и 3,05% и обеспечить высокую сохранность птицы (100%). Более высокие показатели по живой массе при меньших затратах кормов на 1 кг прироста отмечены у бройлеров, получавших комбикорма с включением 3,0% масла сурепицы. Бройлеры этой группы по живой массе на 35-е сутки статистически достоверно превосходили птицу контрольной группы на 6,19%, а по среднесуточному приросту — на 6,32%, при затратах корма на 1 кг прироста живой массы 1,556 кг, что меньше, чем у бройлеров контрольной группы, на 3,05% за счёт лучшей переваримости и использования основных питательных веществ корма.

The investigation took place at the SGTS “Zagorskoe EPKh” of the Moscow region in 2021–2022. The effect of cress oil (as opposed to sunflower oil) in feed was tested on four groups of 1–35 days-old broiler chickens “Smena 9” kept in cages. Oil from cress “Nadezhda” contains relatively low content of saturated fatty acids (5.59%). Total concentration of palmitic and stearic fatty acids amounted to 1.95%. However, oleic acid quantity (61,0%) exceeded the one in sunflower oil by 33.9% (Р ≤ 0.001). Introduction of 1.5 and 3.0% of cress oil into feed-stuff improved chicken weight gain by 5.27 and 6.19%, reduced feed costs for 1 kg of weight gain by 1.99 and 3.05%, and positively affected poultry livability (100%). Chickens consuming feed-stuff with 3.0% of cress oil showed better weight gain and lower feed costs for 1 kg of weight gain. On the 35th day this group significantly exceeded the control group in body weight by 6.19% and in daily average weight gain — by 6.32%. Forage consumption for 1 kg of weight gain amounted to 1.556 kg due to better digestibility of essential nutrients while the control group required 3.05% more feed.
The effect of Bacillus spp.-based biological preparations on oats’ productivity
Authors: Платонов А.В. , Рассохина И.И. , Лаптев Г.Ю.
Published: November 2022

В статье показаны результаты мелкоделяночных полевых опытов, проведённых в 2019–2021 годах, по оценке действия препаратов, созданных на основе бактерий Bacillus subtilis и Bacillus megaterium, на рост и продуктивность овса посевного сортов Яков и Лев. Исследования проводились в Вологодской области на полях ВолНЦ РАН. Микробные препараты использовались дважды: для предпосевного замачивания семян в рабочем растворе препарата в течение 2 ч и для опрыскивания филлосферы растений на стадии кущения. В рамках исследований у растений на стадии кущения и трубкования оценивали следующие параметры: кустистость, количество листьев, сырую и сухую массу. На стадии начала созревания зерна проводили оценку структуры урожая. В результате опытов было выявлено, что препараты, созданные на основе бактерий B. subtilis и B. megaterium, оказывали положительное влияние на рост и продуктивность овса посевного в условиях Вологодской области. Повышение продуктивности растений под влиянием бактерий биопрепаратов произошло за счёт как увеличения продуктивной кустистости, так и некоторого увеличения количества зерновок в метёлке. Более стабильное влияние на биометрические параметры растений, вне зависимости от года исследования, было зафиксировано у препарата, основу которого составляют микроорганизмы B. megaterium. У овса сорта Яков в зависимости от года исследований наблюдалось увеличение зерновой продуктивности при использовании препарата с живыми бактериями B. subtilis на 14–20%, при использовании B. megaterium — на 12–25%, урожайность овса сорта Лев возрастала относительно контроля на 6–29 и 15–17% соответственно.

This article reports on the field trials conducted in 2019–2021. The aim was to test the effect of preparations, based on Bacillus subtilis and Bacillus megaterium on the growth and productivity of oats Yakov and Lev. This investigation took place at the Vologda Research Center of the Russian Academy of Sciences. Microbial preparations were used twice: for 2 hour-seed treatment as well as phyllosphere spraying at tillering stage. Such traits as tilling capacity, leaf number, green and dry masses were analyzed at tillering and shooting stages. Oat productivity was tested at the early stage of grain ripening. Preparations positively affected plant performance. Productivity grew due to higher tilling and grain production capacities affected by bacteria. The B. megaterium-based preparation showed stable positive impact on plants throughout all the years. B. subtilis increased grain productivity of Yakov by 14–20% while B. megaterium — by 12–25%. Yield increases of Lev amounted to 6–29 and 15–17%, respectively.
Targeted photodynamic neutralization of SARS-CoV-2 mediated by singlet oxygen
Authors: Yao Ruhui , Hou Jian , Zhang Xin , Li Yi , Lai Junhui , Wu Qinqin , Liu Qinglian , Zhou Lei
Published: November 2022

The SARS-CoV-2 virus has been on a rampage for more than two years. Vaccines in combination with neutralizing antibodies (NAbs) against SARS-CoV-2 carry great hope in the treatment and final elimination of COVID-19. However, the relentless emergence of variants of concern (VOC), including the most recent Omicron variants, presses for novel measures to counter these variants that often show immune evasion. Hereby we developed a targeted photodynamic approach to neutralize SARS-CoV-2 by engineering a genetically encoded photosensitizer (SOPP3) to a diverse list of antibodies targeting the WT spike protein, including human antibodies isolated from a 2003 SARS patient, potent monomeric and multimeric nanobodies targeting RBD, and non-neutralizing antibodies (non-NAbs) targeting the more conserved NTD region. As confirmed by pseudovirus neutralization assay, this targeted photodynamic approach significantly increased the efficacy of these antibodies, especially that of non-NAbs, against not only the WT but also the Delta strain and the heavily immune escape Omicron strain (BA.1). Subsequent measurement of infrared phosphorescence at 1270 nm confirmed the generation of singlet oxygen (1O2) in the photodynamic process. Mass spectroscopy assay uncovered amino acids in the spike protein targeted by 1O2. Impressively, Y145 and H146 form an oxidization “hotspot”, which overlaps with the antigenic “supersite” in NTD. Taken together, our study established a targeted photodynamic approach against the SARS-CoV-2 virus and provided mechanistic insights into the photodynamic modification of protein molecules mediated by 1O2.
Mapping nanocrystalline disorder within an amorphous metal–organic framework
Authors: Sapnik Adam , Sun Chao , Laulainen Joonatan , Johnstone Duncan , Brydson Rik , Johnson Timothy , Midgley Paul , Bennett Thomas , Collins Sean
Published: November 2022

Intentionally disordered metal–organic frameworks (MOFs) display rich functional behaviour. However, the characterisation of their atomic structures remains incredibly challenging. X-ray pair distribution function techniques have been pivotal in determining their average local structure but are largely insensitive to spatial variations in the structure. Fe-BTC is a nanocomposite MOF, known for its catalytic properties, comprising crystalline nanoparticles and an amorphous matrix. Here, we use scanning electron diffraction to first map the crystalline and amorphous components to evaluate domain size and then to carry out electron pair distribution function analysis to probe the spatially separated atomic structure of the amorphous matrix. Further Bragg scattering analysis reveals systematic orientational disorder within Fe-BTC’s nanocrystallites, showing over 10° of continuous lattice rotation across single particles. Finally, we identify candidate unit cells for the crystalline component. These independent structural analyses quantify disorder in Fe-BTC at the critical length scale for engineering composite MOF materials.
Exploiting Directed Self-Assembly and Disassembly for off-to-on Fluorescence Responsive Live Cell Imaging
Authors: Curtin Niamh , O'Shea Donal , Garre Massimiliano , Bodin Jean-Baptiste , Solem Nicolas , Meallet-Renault Rachel
Published: November 2022

A bio-responsive nanoparticle was formed by the directed self-assembly (DSA) of a hydrophobic NIR-fluorophore with poloxamer P188. Fluorophore emission was switched off when part of the nanoparticle, however upon stimulus induced nanoparticle dis-assembly the emission switched on. The emission quenching was shown to be due to fluorophore hydration and aggregation within the nanoparticle and the turn on response attributable to nanoparticle disassembly with embedding of the fluorophore within lipophilic environments. This was exploited for temporal and spatial live cell imaging with a measurable fluorescence response seen upon intracellular delivery of the fluorophore. The first dynamic response, seen within minutes, was from lipid droplets with other lipophilic regions such as the endoplasmic reticulum, nuclear membranes and secretory vacuoles imageable after hours. The high degree of fluorophore photostability facilitated continuous imaging for extended periods and the off to on switching facilitated the real-time observation of lipid droplet biogenesis as they emerged from the endoplasmic reticulum. With an in-depth understanding of the principles involved, further assembly controlling functional responses could be anticipated.
Accelerating Organic Electronic Materials Design with Low-Cost, Robust Molecular Reorganization Energy Predictions
Authors: Li Cheng-Han , Tabor Daniel
Published: November 2022

A critical bottleneck for the design of high-conductivity organic materials is finding molecules with low reorganization energy. The development of low-cost machine-learning-based models for calculating the reorganization energy has proven to be challenging. Here we combine a graph-based neural network recently benchmarked for drug design applications, ChIRo, with low-cost conformational features and show the feasibility of reorganization energy predictions on the benchmark QM9 dataset without needing DFT geometries.
Augmenting Polymer Datasets by Iterative Rearrangement
Authors: Lo Stanley , Seifrid Martin , Gaudin Théophile , Aspuru-Guzik Alán
Published: November 2022

One of the biggest obstacles to successful polymer property prediction is an effective representation that accurately captures the sequence of repeat units in a polymer. Motivated by the successes of data augmentation in computer vision and natural language processing, we explore augmenting polymer data by rearranging the molecular representation while preserving the correct connectivity, revealing additional substructural information that is not present in a single representation. We evaluate the effects of this technique on the performance of machine learning models trained on three experimental polymer datasets and compare them to common molecular representations. Data augmentation improves deep learning property prediction performance compared to equivalent (non-augmented) representations. In datasets where the target property is primarily influenced by the polymer sequence rather than experimental parameters, this data augmentation technique provides the molecular embedding with more information to improve property prediction accuracy.
Oxygen K-edge spectra of Yb2O 3 polymorphs, Yb2SiO5, and Yb2Si2O7: First-principles simulations and EELS measurements
Authors: Ogawa Takafumi , Miao Bin , Wei Jiake , Feng Bin , Shibata Naoya , Matsudaira Tsuneaki , Kitaoka Satoshi
Published: November 2022

First-principles calculations, along with a core-hole technique, are adopted to simulate oxygen K-edge spectra for three polymorphs of Yb2O3 and two types of ytterbium silicates (i.e., Yb2SiO5 and Yb2Si2O7). The twe Yb silicates are compared with experimental spectra, which are measured via electron energy-loss spectroscopy for a polycrystalline sample including both phases. The simulated O K-edge spectra of cubic, monoclinic, and hexagonal Yb2O3 exhibit characteristic twin peaks, which resulted from crystal fi eld splitting of unoccupied Yb5 d orbitals in Yb-O polyhedra. Spacing between the two peaks refl ects a degree of distortion of the polyhedra and local coordination environments around O atoms. The simulated and experimental O K-edge spectra of Yb2SiO5 and Yb2Si2O7 also show twin peaks, where lower-energy peaks are signifi cantly reduced compared to those of Yb2O3. A small diff erence in the lower-energy peaks, which refl ect the local environments of O atoms, enables us to identify Yb silicate phases from an O K-edge spectrum. The derived insights could be widely extended to rare-earth oxides.
Hormonal parameters and embryological outcomes of in vitro fertilisation/intra cytoplasmic sperm injection cycles in women using dydrogesterone for the prevention of premature luteinizing hormone surge during ovarian stimulation
Authors: Korneeva Irina E. , Kovalchuk Alla I. , Nazarenko Tatiana A. , Mityurina Elena V. , Perminova Svetlana G. , Bachurin Aleksei V. , Ivanets Tatiana Yu.
Published: November 2022

Aim. To evaluate the hormonal parameters and embryological outcomes of an ovarian stimulation protocol using dydrogesterone to prevent the premature LH surge in IVF/ICSI programmes.
Materials and methods. A prospective study randomised, including 79 women with normal ovarian reserve undergoing ovarian stimulation for IVF/ICSI with recombinant FSH (rFSH) from Day 2 or 3 of the menstrual cycle. To prevent the premature LH surge, participants in Group 1 (n=38) received oral dydrogesterone 20 mg/day from the start of ovarian stimulation until the day of ovulation trigger administration. Participants in Group 2 (n=41) received a GnRH antagonist. We evaluated the starting and total dose of gonadotropins, duration of stimulation, serum levels of LH, oestradiol and progesterone on Day 1 and 6 of stimulation and the day of trigger administration, number of retrieved and mature oocytes, fertilization rate, and the number of blastocysts and cryopreserved embryos.
Results. There were no significant differences in most hormonal parameters, characteristics of the ovarian stimulation and embryological outcomes between the two groups. Serum levels of progesterone in the dydrogesterone arm were higher than in the GnRH antagonist arm (2.3 nmol/l [2.03.4] vs 1.5 [1.02.4] nmol/l; p=0.026), but without any impact on the embryological outcomes.
Conclusion. Prevention of premature LH surge in ovarian stimulation cycles using oral dydrogesterone may represent a convenient alternative to the conventional use of GnRH antagonists, reducing the number of required injections and potentially increasing the convenience in patients who are not planning a fresh embryo transfer.
Opportunities and clinical significance of preoperative diagnosis of infiltrative endometriosis
Authors: Podzolkova Natalia M. , Kuznetsov Roman E. , Glazkova Olga L. , Gorozhanina Anastasiya A. , Churayants Vladimir V. , Romanovskaya Olga A. , Sozaeva Larisa G. , Cheporev Leonid A.
Published: November 2022

Aim. To optimize preoperative diagnosis of infiltrative forms of genital endometriosis.
Materials and methods. We analyzed the results of the preoperative examination and surgical treatment of 667 patients from 22 to 49 years old (31.4 [27.3; 34.2]) with external endometriosis presented with pelvic pain, dysmenorrhea, dyspareunia (n=580), and primary or secondary infertility (n=215). The duration of the disease ranged from 1 to 16 years. Seventy-eight (11.69%) patients had a history of surgery for external endometriosis. The serum concentration of the CA-125 tumor marker was measured by immunochemiluminescence assay. Colonoscopy was performed in 655 cases, and cystoscopy in 66 cases. In addition, pelvic ultrasound was performed for all patients. Pelvic magnetic resonance imaging (MRI) was performed with an intravenous bolus injection of a contrast agent.
Results. Patients with endometrioid ovarian cysts (n=564) and "minor" forms of endometriosis (n=44) predominated. Endometrioid infiltrates occurred in 59 (8.84%) patients. In the group of patients with infiltrates, 18.64% had a history of surgery for endometriosis; 5.7% had a recurrence. Patients with retrocervical endometriosis and endometriosis of uterosacral ligaments predominated among females with infiltrative forms. No statistically significant differences in CA-125 concentration between patients with and without infiltrates were observed. The infiltrate was revealed, and its topography was described in 49 (83.05%) patients using ultrasound and 56 (94.81%) patients using MRI. All patients with dysuria had ultrasound, MRI, colonoscopy and cystoscopy.
Conclusion. The combined use of pelvic ultrasound and MRI provides high accuracy in diagnosing infiltrative endometriosis.
Uterine leiomyosarcoma and disseminated peritoneal leiomyomatosis in the surgical treatment of uterine myoma: a retrospective analysis
Authors: Seregin Alexander A. , Kosova Yana A. , Seregina Polina A. , Ponomareva Yulia N. , Nadezhdenskaia Anastasiia B. , Kirilova Eleonora V. , Asaturova Aleksandra V. , Tregubova Anna V. , Magnaeva Alina S. , Ishchuk Maria P. , Ovodenko Dmitry L.
Published: November 2022

Aim. To analyze the incidence and types of adverse outcomes and complications of laparoscopic myomectomies.
Materials and methods. This work is a retrospective study based on data from the Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology. We analyzed 711 case histories of patients diagnosed with uterine myoma who received surgical treatment in the Department of Innovative Oncology and Gynecology from 2015 to 2019. The frequency of malignant neoplasms, verified by pathomorphological examination, and the characteristics of surgical interventions performed in these patients were comparatively evaluated.
Results. Surgical interventions for uterine myoma are leading in gynecology due to the high prevalence of such disorders. Conservative myomectomy remains the "gold standard" in organ-sparing surgery. However, during surgeries for suspected benign neoplasms, there is a risk of morcellation of the malignant tumor, significantly worsening patient survival outcomes. In our study, the incidence of uterine leiomyosarcoma in suspected benign neoplasms was 0.98%. The probability of parasitic myomas or disseminated perineal leiomyomatosis after myomatous nodule morcellation is 0.19%.
Conclusion. No reliable information about the malignant potential of the tumor and its proliferative activity can be obtained until a definitive pathomorphological examination. The above considerations warrant the routine use of prophylactic measures to prevent tumor cell dissemination.