bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of YouTube® videos on thrombolysis and thrombectomy for deep venous thrombosis
Authors: Yan Qi , Rajesh Aashish , Davies Mark G
Published: October 2023

Objective

YouTube® has gained popularity as an unofficial educational resource for surgical trainees, but its content's quality and educational value remain to be evaluated. The aim of this study is to analyze the current content on these techniques for lower extremity DVT (LEDVT) on YouTube®.

Methods

A search was performed on YouTube® using 13 search terms in August 2022 on a clear-cached browser. Open-access videos focusing on the surgical techniques of venous thrombolysis or thrombectomy for LEDVT were included. Quality and educational value were assessed and graded based on metrics for accountability (4 items), content (13 items), and production (9 items).

Results

Out of 138 videos regarding LEDVT oriented towards medical professionals, only 14 met inclusion criteria. Videos ran for a median of 3.4 min (range 0.37–35.6 min) with a median of 941 views (range 106–54624). Videos scored a median of 5.5 (range 1.0–8.0) out of 11 for content, a median of 2.0 out of 6.0 (range 0.0–2.0) for accountability, and a median of 5.5 out of 9.0 (range 3.0–9.0) for production.

Conclusion

Few YouTube® videos focus on the technical aspects of DVT thrombolysis/thrombectomy, and they vary significantly in content with overall poor accountability and production quality.
A Clinical-Community Comparison of Parent-Child Emotion Conversations About the Past and the Anticipated Future
Authors: Russell Sophie , Bird Amy L. , Herbert Jane S.
Published: October 2023

This study aimed to assess differences in emotion and elaboration quality between clinical and community child cohorts in both past reminiscing and future worry conversations. We analyzed 54 Australian parents (46 mothers, 8 fathers) and their 8- to 12-year-old children ( M = 9.63, SD = 1.29; 28 boys, 26 girls) in reminiscing interactions. Dyads were recruited from local schools (community cohort, n = 26) or a children’s psychology clinic waitlist (clinical cohort, n = 28). Clinical cohort children engaged in less emotion exploration in both past and future conversations, as did parents for future conversations. Elaboration quality did not differ. Parent-son dyads differed in the clinical cohort, exhibiting significantly lower emotion resolution than the community cohort, or parent-daughter dyads when discussing past events. These findings suggest that discussing anticipated negative events may be a relevant point of family-based intervention for anxious children. Additionally, this study highlights the importance of parent-son emotional discussion.
Idiopathic pulmonary haemosiderosis misdiagnosed as haemolytic anaemia: a case report
Authors: Ma Xueqin , Ju Changxi , Liu Xiaotong , Tian Ying , Wu Jing , Li Yuanxiao
Published: October 2023

Idiopathic pulmonary haemosiderosis is a rare disease primarily affecting children. The condition is characterized by widespread bleeding from alveolar capillaries, resulting in symptoms such as haemoptysis, shortness of breath and iron deficiency anaemia. However, it is not a specific disease and sometimes can manifest solely as anaemia, which may be easily overlooked and misdiagnosed. The purpose of this case report was to describe a 1-year-old boy who exhibited haemolytic anaemia as the only symptom of idiopathic pulmonary haemosiderosis, with the intention of offering clinical insights into the precise diagnosis and subsequent management of this rare and easily misdiagnosed disease. Clinicians should keep idiopathic pulmonary haemosiderosis in mind when evaluating children with haemolytic anaemia and promptly initiate testing and treatment to prevent misdiagnosis and improve outcomes.
Exudative glomerulonephritis associated with acute leptospirosis in dogs
Authors: Hilbe Monika , Posthaus Horst , Paternoster Giulia , Schuller Simone , Imlau Michelle , Jahns Hanne
Published: October 2023

In the past 20 years in Switzerland, dogs with suspect acute leptospirosis frequently showed severe glomerular changes that had not been previously reported. These features were characterized by abundant extravasated erythrocytes and fewer neutrophils accompanied by marked fibrin exudation into the urinary space that was interpreted as an exudative glomerulonephritis (GN). This retrospective study describes this significant glomerular pathological change and investigates the association with leptospirosis. Tissues from 50 dogs with exudative GN, retrieved from 2 pathology archives in Switzerland were reviewed using hematoxylin and eosin, periodic acid-Schiff, phosphotungstic acid-hematoxylin, and Warthin and Starry stains. Clinical and postmortem data were collected for each case. Immunohistochemistry (IHC) and/or polymerase chain reactions were used as confirmatory tests for leptospirosis. While all 50 cases had clinical and pathological features supporting a diagnosis of leptospirosis, 37 cases were confirmed for the disease. Using a LipL32 antibody in addition to the OMV2177 antibody raised against the lipopolysaccharide of Leptospira interrogans serovar Copenhageni increased the detection rate of Leptospira by IHC in exudative GN from 24% to 62%. Signalment, seasonality, clinical signs, blood results, and pathological changes in dogs with exudative GN were similar to those reported for dogs without GN and confirmed infection by Leptospira spp.. Exudative GN was common among Swiss dogs with leptospirosis where it caused acute severe disease. Leptospirosis should be considered as a cause of this new pathologic feature by the pathologist. The pathogenesis remains unclear, but involvement of a geographic-specific serovar with unique virulence factors is suspected and warrants further investigation.
The neural oscillations in delta- and theta-bands contribute to divided attention in audiovisual integration
Authors: Yang Xi , Ying Chen , Zhu Lan , Wenjing Wang
Published: October 2023

One of key mechanisms implicated in multisensory processing is neural oscillations in distinct frequency band. Many studies explored the modulation of attention by recording the electroencephalography signals when subjects attended one modality, and ignored the other modality input. However, when attention is directed toward one modality, it may be not always possible to shut out completely inputs from a different modality. Since many situations require division of attention between audition and vision, it is imperative to investigate the neural mechanisms underlying processing of concurrent auditory and visual sensory streams. In the present study, we designed a task of audiovisual semantic discrimination, in which the subjects were asked to share attention to both auditory and visual stimuli. We explored the contribution of neural oscillations in lower-frequency to the modulation of divided attention on audiovisual integration. Our results implied that theta-band activity contributes to the early modulation of divided attention, and delta-band activity contributes to the late modulation of divided attention to audiovisual integration. Moreover, the fronto-central delta- and theta-bands activity is likely a marker of divided attention in audiovisual integration, and the neural oscillation on delta- and theta-bands is conducive to allocating attention resources to dual-tasking involving task-coordinating abilities.
Profit enhancement and grid frequency control by energy level scheduling of CAES system in wind-connected electrical system
Authors: Das Shreya Shree , Kumar Jayendra
Published: October 2023

The maintenance of power balance poses significant challenges in renewable combined deregulated power systems due to the unpredictable nature of renewable energy sources. This situation leads to economic instability within the system. However, an energy storage system can help maintain energy supply and control system stability for renewable incorporated thermal power plants. Unlike in regulated markets, energy prices in deregulated markets are not fixed by any government body or particular company. Instead, the Independent System Operator (ISO) serves as the main entity in the electrical market, gathering tenders from Generation Companies (GENCOs), Distribution Companies (DISCOs), and Transmission Companies (TRANSCOs). The market controller regulates energy prices using Nodal Pricing (NP), which provides economic benefits to both GENCOs and DISCOs. However, the unpredictability of renewable sources often results in a decline in system profit due to the production of an imbalance price (CostIMC) caused by a mismatch in contracted power generation from the renewable power plant. To address these issues, this study proposes a novel combined system that utilizes a suitable scheduling technique for the optimum operation of a wind farm-compressed air energy storage (CAES) system to maximize profit and revenue while maintaining grid frequency. The CAES system’s energy level is divided into four different levels, and an optimal strategy has been developed to efficiently utilize the CAES system to maintain grid frequency. This work has been conducted in both regulated and deregulated environments using a modified IEEE 30-bus system. The proposed method has been compared with an existing approach and has yielded better results in all aspects.
Agnes Heller: The time of your life
Authors: Roberts David
Published: October 2023

The following reflections, occasioned by Agnes Heller’s death, attempt to reconstruct Heller’s sense of temporality and historicity as the key to her rethinking of the idea of philosophy of history after the demise of the grand narratives in the form of a fragmentary philosophy of history and a theory of history.
Teaching Multiplicative Thinking With Virtual Representations to Children With Mathematics Difficulty
Authors: Satsangi Rajiv , Sigmon Stephanie D.
Published: October 2023

Whole number computations are a critical skill that serves as a foundation upon which higher-order concepts in mathematics are taught to children. To facilitate their instruction, educators often use multiple representations to support a child’s cognition. Representations with physical manipulatives are widely studied through a graduated instructional sequence featuring concrete, representational, and abstract stages of learning. In contrast, research on representational sequences featuring virtual manipulatives is less robust. Thus, this study evaluated an instructional strategy with virtual manipulatives, static representational drawings, and abstract algorithms to teach multiplication to three U.S. elementary students with mathematics difficulty. A functional relation was established via a single-subject multiple probe design between the treatment and students’ accuracy performance. Baseline-corrected Tau estimates confirmed a medium effect size for all three students, while student performance on measures assessing the number of errors committed and the duration of sessions also returned favorable findings.
Biodegradable carboxymethyl cellulose based material for sustainable/active food packaging application
Authors: El-Sakhawy Mohamed , Tohamy Hebat-Allah S , AbdelMohsen Mona M , El-Missiry Mostafa
Published: October 2023

This work goal is to develop a valuable biodegradable material for sustainable packaging. The utilization of agriculture wastes to produce biodegradable packaging films based on carboxymethyl cellulose (CMC) will reduce its price. CMC was prepared from sugar cane bagasse, and used to prepare composite films with mandarin and cantaloupe peels extracts of different ratios. The effects of these extracts on the mechanical and antimicrobial properties of the prepared films were evaluated. Thus, the films incorporated with 10% concentration of mandarin and cantaloupe peels extract exhibited excellent antimicrobial properties against gram positive, gram negative bacteria and pathogenic yeast than the other lower concentrated films. The physiochemical properties of each developed biodegradable films were characterized using Fourier Transform Infra-Red (FTIR) spectroscopy, X-Ray diffraction analysis (XRD), Scanning Electron Microscopy (SEM) and antimicrobial. The reflected work is a novel approach, and which is vital in the conversion of organic waste to value-added product development.
Extractive Labor: A Lethal Legacy of Racialized Colonial Rule
Authors: Scarritt Arthur
Published: October 2023

How and why does colonial domination kill off the very labor it depends on? While settler colonial studies provide one of the only theorizations of the systemic elimination of populations, they see it as antithetical to labor exploitation, and thus cannot answer this question. I therefore build on recent critiques of settler colonial studies to develop the concept of racialized extractive labor regimes: race marking labor as disposable, as realizing value through expending workers’ lives. I then articulate these dynamics through a comparison of the highly divergent cases of early colonialism in Peru and what is now the United States, first across initial settlement and then as they shifted to racialization decades later. While settler colonial studies emphasize land acquisition as colonialism’s defining feature, my comparison reveals that elites’ drive for indelible inequality actually shapes colonial projects. And in order to maintain their vaunted positions, elites ultimately construct racialized extractive labor regimes that predicate their domination on the regularized elimination of racialized Others. This analysis therein provides new insights into the elitist nature of colonialism and the logics of elimination and racialization through which it runs.
Laser forming of aluminium foam sandwich into a shock-absorbing structural part
Authors: Changdar Anirban , Shrivastava Ankit , Chakraborty Shitanshu Shekhar , Dutta Samik
Published: October 2023

The inefficacy of the conventional methods to form Aluminium Foam Sandwich (AFS) has led to the evolution of laser forming as an alternative. However, the current literature lacks studies that demonstrate the capability of the laser forming to form a targeted part out of AFS. The current study for the first time proposed a methodology and revealed salient factors relevant to laser forming an AFS panel into a prescribed scaled-down model (bumper beam). Estimation of the scan line position and the experimental methodology to obtain the desired process parameters against each scan line to obtain the targeted part are demonstrated. Chances of failure of the AFS part during the laser forming were investigated using finite element simulation. The laser-formed part that was finally obtained conformed well to the targeted shape and also exhibited improved flexural strength with no loss of local compressibility under the three-point bending test.
Observer-based adaptive dynamic sliding mode control for automatic clutch position tracking
Authors: Ding Jingang , Jiao Xiaohong
Published: October 2023

The automatic clutch’s precise and stable position tracking is critical in automated manual transmission, significantly influencing vehicle performance. Clutch position control is challenging due to directly unmeasurable clutch output position, nonlinear characteristics, parameter uncertainties, and external disturbance of the automatic clutch system. This paper proposes an observer-based adaptive dynamic sliding mode control strategy to overcome these obstacles to the clutch position tracking process. The extended state observer (ESO) introduced in the designed strategy handles total disturbance, including nonlinearities and uncertainties for feedback control and total compensation. A sigmoid tracking differentiator arranges the transient process and smooth approach signal for the reference input and its differential signal. An adaptive dynamic sliding mode controller acts as the primary feedback control to realize fast and precise position tracking of the automatic clutch system based on the signal from ESO. Simulation and hardware-in-loop (HIL) experimental tests verify the effectiveness and advantage of the proposed control strategy for the clutch position tracking performance in the face of parameter perturbation and external disturbance, for example, the root mean square value of static tracking error of the designed strategy is 14.9% and 24.7% lower than that of ESO-based sliding mode control and robust sliding mode control strategy in the HIL test, respectively.
Environmental technology import and carbon emissions intensity convergence: Analysis for the Belt and Road Initiative countries
Authors: Salam Muhammad , Yingzhi Xu
Published: October 2023

Since the official launch of the Belt and Road Initiative (BRI) in 2013, China and the BRI countries have been working for the implementation of certain environmental measures to make the BRI project green and clean. For this purpose, China and the BRI countries have planned to implement certain environmental measures. Although China can efficiently implement these measures, most of the BRI countries face technological deficiencies and lack of proper environmental plannings. To tackle these deficiencies, the BRI countries can import environmental technology from China. Moreover, they can communicate their environmental protection policies with China for better policy guidance. The current study, therefore, aims to examine whether the BRI countries’ import of environmental technology from China can reduce carbon emissions in these countries. Moreover, it also examines that whether these countries should follow the environmental policy and the import policy of China or they should follow the six European countries (EU-6) with minimum carbon emissions intensity. This study considers a sample of 88 selected BRI countries (BRI-88) for the period 2001–2019. The results obtained with β convergence (based on the panel quantile regression model) suggest that not all the BRI countries but only the BRI countries with relatively higher carbon emissions intensity can significantly reduce their average carbon emissions intensity by importing environmental technology from China. Moreover, BRI countries can follow the environmental policy of China which is more feasible for them. However, regarding the environmental goods import policy, BRI countries can follow both China and the EU-6.
How does CEO green experience affect green innovation of energy firms? Evidence from China
Authors: Zhang Jingxue , Zhang Kun
Published: October 2023

CEO characteristics influence their strategic preferences, which are crucial for promoting corporate green innovation (GI). However, the influence and its mechanisms of CEO green experience (GreCEO) on GI of energy firms, especially when comparing different firm types holistically, remain understudied. This study used a moderated mediation model with fixed effects to examine the relationship between GreCEO and GI of energy firms, based on the unbalanced panel data of 821 listed Chinese energy firms during 2004–2021. We find that: (1) GreCEO positively affects energy firms’ GI. (2) Heterogeneity exists in the GI effect of GreCEO regarding business ownership and industry characteristics, and this effect is more prominent in non-state-owned energy firms and high-tech energy firms. (3) Green management (GM) and debt-to-asset ratio (DAR) partially mediate GreCEO's impact on GI of energy firms. (4) Renewable energy policy (REP) moderates the relationship between GreCEO and GI of energy firms, and its influencing mechanisms. In contrast to studies that focus on the direct effect of CEO characteristics on GI, this study identifies the potential influencing mechanisms through which GreCEO affects GI of energy firms. In addition, the moderation analysis reveals the boundary condition that GreCEO affects GI, enriching our understanding of GreCEO's effect on GI from the perspective of a firm's internal conditions and external policy environment. Regarding green development, CEOs’ early experience should be included in the management system and evaluation criteria of energy firms. The Chinese government should continue to implement the REP and accelerate energy firms’ green transition.
Do technological innovations and clean energies ensure CO2 reduction in China? A novel nonparametric causality-in-quantiles
Authors: Pata Ugur Korkut , Luo Rundong , Kartal Mustafa Tevfik , Adebayo Tomiwa Sunday , Ullah Sami
Published: October 2023

Sustainable manufacturing and green growth are prominent concerns for both advanced and emerging countries to reach the sustainable development goals. Most emerging economies rely heavily on fossil fuels to meet their energy needs, which increases greenhouse gas emissions and degrades environmental quality. This study accessed the role of renewable energy, trade globalization, and technological innovations in predicting environmental quality in China using quarterly data from 2001 to 2019. The study employed a novel nonparametric causality-in-quantiles approach, because causality may not exist in the mean, but a higher-order relationship may be observed in the variance. The outcomes revealed that renewable energy, globalization and technology, all have significant and asymmetric power to predict carbon emissions and ecological footprint in China. The main finding of the study is that technology seems to be the most significant predictor of carbon emissions, while the ecological footprint is highly driven by renewable energy. Based on these results, the Chinese government should reduce ecological degradation by increasing investments in technological progress and renewable energy to achieve sustainable development.
Effects of methylphenidate on femoral bone growth in male rats
Authors: Say Gökçe Nur , Önger Mehmet Emin , Say Ferhat , Yontar Onur , Yapıcı Oktay
Published: October 2023

The use of Methylphenidate (MP) can have adverse effects on bone growth and mineralization. This study aimed to investigate the underlying pathophysiology of MP-induced skeletal deficits in growing rats using stereological and immunohistochemical methods. Male rats, aged 4 weeks, were orally treated with MP through an 8-h/day water drinking protocol. The rats ( n=30) were randomly divided into three groups: MP-High Dose (30/60 mg/kg/day MP), MP-Low Dose (4/10 mg/kg/day MP), and control (water only). After 13 weeks, the femoral bones were assessed using calliper measurements, dual-energy X-ray absorptiometry, and biomechanical evaluation. The total femur volume, cartilage volume, growth zone volume, and volume fractions were determined using the Cavalieri method. Immunohistochemical analyses were conducted using alkaline phosphatase and anti-calpain antibody staining. Rats exposed to MP exhibited significant reductions in weight gain, femoral growth, bone mineralization, and biomechanical integrity compared to the control group. The total femoral volume of MP-treated rats was significantly lower than that of the control group. The MP-High Dose group showed significantly higher ratios of total cartilage volume/total femoral volume and total growth zone volume/total femoral volume than the other groups. Immunohistochemical evaluation of the growth plate revealed reduced osteoblastic activity and decreased intracellular calcium deposition with chronic MP exposure. The possible mechanism of MP-induced skeletal growth retardation may involve the inhibition of intracellular calcium deposition in chondrocytes of the hypertrophic zone in the growth plate. In this way, MP may hinder the differentiation of cartilage tissue from bone tissue, resulting in reduced bone growth and mineralization.
Impact of belimumab therapy on the quality of life in patients with systemic lupus erythematosus: A cohort study
Authors: Prete Marcella , Susca Nicola , Leone Patrizia , De Giacomo Andrea , Bray Antonella , Brunori Giuliano , Favoino Elvira , Perosa Federico , Racanelli Vito
Published: October 2023

Systemic lupus erythematosus (SLE) is a chronic and extremely disabling connective-tissue autoimmune disease with a tremendous impact on the quality of life (QoL). Belimumab, a B-lymphocyte-stimulator-specific inhibitor, is the first biologic drug approved as add-on therapy in patients with active, refractory auto-antibody-positive SLE.

The impact of belimumab on the QoL of SLE patients was evaluated using a generic questionnaire short-form health survey 36 (SF-36) and the disease-specific questionnaire SLE-specific quality of life (SLEQoL).

The Italian version of the SLEQoL and the SF-36 were administered to 46 SLE patients before and after 6 months of belimumab therapy. The control population consisted of 40 age-matched healthy individuals. The questionnaires were completed before and after belimumab treatment and the results were compared using the Wilcoxon signed-rank test. In addition, data from healthy controls and SLE patients were compared using the Mann–Whitney test. Dichotomous variables were compared using Fisher’s exact test.

For SLE patients, the addition of belimumab to their therapeutic regimen significantly improved their health-related QoL (HRQoL), according to the results of the SF-36 and SLEQoL. The comparison of the data obtained before and after belimumab treatment showed a decrease in all six SLEQoL domains and an increase in all eight SF-36 domains. Moreover, treatment led to a reduction in the median prednisone dose, to 0 mg/day (IQR 0–4.5 mg/day). Before belimumab therapy, SLE patients had a worse HRQoL than the control group, based on both questionnaires, but after belimumab treatment the outcome scores between SLE patients and controls were similar, suggesting that belimumab therapy resulted in a strong improvement in HRQoL. These findings were supported by a decrease in the SELENA-SLEDAI score, a measure of disease activity.

In addition to clinical remission and low disease activity, the goals of an innovative therapeutic strategy for SLE should include the attainment of a good HRQoL. Our study demonstrates that the combined use of the SF-36 and SLEQoL questionnaires can provide clinicians with a better understanding of the HRQoL of SLE patients.
Exploring the role of LIAS-related cuproptosis in systemic lupus erythematosus
Authors: Li Yan , Xu Bojun , Zhang Jimin , Liu Xiaoyan , Ganesan Kumar , Shi Guixiu
Published: October 2023

Background

Cuproptosis is a novel mode of cell death, which is strongly related to energy metabolism in mitochondria and regulated by protein lipoylation. Currently, the molecular mechanisms of cuproptosis-related genes (CRGs) involved in systemic lupus erythematosus (SLE) largely remained unclear, our study is aimed to explore the mechanisms of cuproptosis and CRGs involved in SLE.

Methods

Bulk RNA-seq datasets were collected to display the expressions of CRGs in peripheral blood mononuclear cells (PBMCs) of SLE and healthy individuals, and then ROC analysis was used to establish the diagnostic models of CRGs. Next, the immune infiltration analyses were applied to reveal the difference of immune cells infiltration in LIAS-low and LIAS-high group. Additionally, WGCNA analysis was performed to find the gene modules significantly correlated with the LIAS expression level. We also performed the functional enrichment analyses for LIAS-related gene modules to determine the potential pathways involved in the development of SLE. Finally, scRNA-seq dataset was used to cluster immune cell subsets, reveal the activated pathways, and study cell-cell interactions in LIAS-low and LIAS-high cells.

Result

We found CDKN2A was significantly increased and LIAS was significantly decreased in SLE patients compared with healthy individuals. The AUC score showed that LIAS had a great diagnostic value than other CRGs. Additionally, the results of immune infiltration analyses showed that immune cells proportion were diverse in LIAS-low and LIAS-high samples. The gene sets related to LIAS expression level were involved in dephosphorylation of JAK1 by SHP1, phosphorylation of STAT2, cytokine signaling in immune system, expression of interferon-alpha and beta, inhibition of JAK kinase activity by SOCS1/3, and so on. Finally, the results of cell-cell communication showed that CCL- (CCL5 + CCR1) and ANNEXIN- (ANXA1 + FPR1) might play an essential role in the communication network between LIAS-low and LIAS-high cells.

Conclusion

Above findings inferred that LIAS-mediated cuproptosis might involve in a comprehensive cellular and molecular mechanism to cause the occurrence and development of SLE.
The protein kinase A signaling pathway mediates the effect of electroacupuncture on excessive contraction of the bladder detrusor in a rat model of neurogenic bladder
Authors: Liu Qiong , Qu Qi-Rui , Xu Ming , Liu Ji-Sheng , Qi Fang , Yi Xi-Qin , Zhang Hong , Zhou Lu , Ai Kun
Published: October 2023

Background:

Neurogenic bladder (NB) is a form of neurological bladder dysfunction characterized by excessive contraction of the bladder detrusor. Protein kinase A (PKA) signaling is involved in the contraction of the detrusor muscle.

Aims:

To investigate whether PKA signaling mediates the effect of electroacupuncture (EA) on the excessive contraction of the bladder detrusor in NB.

Methods:

Sixty rats were randomly divided into control, sham, NB, NB + EA, and NB + EA + H89 (a PKA receptor antagonist) groups. The modified Hassan Shaker spinal cord transection method was used to generate a NB model. After EA intervention for one week, urodynamic tests were used to evaluate bladder function, hematoxylin and eosin staining was conducted to assess morphological changes, enzyme-linked immunosorbent assay (ELISA) was performed to measure the concentration of PKA, and Western blotting was conducted to measure the protein levels of phosphorylated myosin light chain kinase (p-MLCK)/p-MLC.

Results:

The results showed that NB resulted in morphological disruption, impairment of urodynamics, and decreases in the concentration of PKA and the protein levels of p-MLCK/p-MLC. EA reversed the changes induced by NB dysfunction. However, the improvement in urodynamics and the increases in the concentration of PKA and the protein levels of p-MLCK/p-MLC were inhibited by H89.

Conclusion:

Our findings indicate that the PKA signaling pathway mediates the beneficial effect of EA on excessive contraction of the bladder detrusor in a rat model of NB.
Trends and Directions of Employee Experience: A Bibliometric Review for Future Research Agenda
Authors: Das Sudhir Chandra , Dhan Sonali Arunima
Published: October 2023

In recent years, the ‘battle of talent’ in the job market emerged as a topic of consideration. It describes the scenario when firms have difficulty both attracting and recruiting talented individuals on staff. As a result, companies are under increased pressure to differentiate themselves from other employees, and improving the employee experience (EE) has been suggested as a potential remedy. The article’s main goals were to assess the global research trends in EE upon outputs of publications, countries, co-occurrences, co-authorships and citations. This article uses a bibliometric analysis of EE publications from 2001 to 2021. A total of 870 publications were deduced following data pre-processing as per the Scopus database. We investigate the parameters of publications using reputable bibliometric measures, and influential institutions and contributing journals are explored. Next, a visualization tool known as VOSviewer is applied to illustrate science mapping analysis. Co-occurrence analysis of keywords is developed to detect the imminent topic trends of the journal. To examine how items are connected, co-authorship networks and citation networks are undertaken. The discussion concludes with some recommendations for potential journal difficulties in the future. The article contributes to the enlargement of EE in the research sector.
GCC Banking Companies Risk Management Practices and its Impact on Their Financial Performance
Authors: Alali Hussain , Haddad Ayman E.
Published: October 2023

This article aims to explore the risk management practices (RMPs) of Islamic banks (IBs) and conventional banks (CBs) in the Gulf Cooperation Council (GCC). It assesses the different phases of RMP, including risk understanding; risk identification; risk assessment and analysis; and risk monitoring. This study conducts a structured survey questionnaire to assess the RMP in both types of banks. We find that both types of banks rank the importance of RMP above the mid-point of the 5-point Likert scale. Using t-test analysis, we find no significant difference in RMP between both types of banks, except for understanding risk practice phase. Managers of CBs have a better understanding of risk management (RM) than IBs. We also examine the impact of RMP on banks’ financial performance. The average return on Assets (ROA) and the average return on equity (ROE) over the years (2010–2017) are used as a proxy for financial performance. Applying robust White regression OLS, we find a significant impact on financial performance measures only for IBs. We refer to the fact that IBs follow the equity approach based on risk-sharing with their clients (depositors and investors). The regulatory authorities may find this study useful in enticing banks to implement the best RMP and so improve banks’ performance.
COVID-19 Pandemic and Household Entrepreneurship in Nigeria: Do Crises Create Necessity-driven and/or Innovative Entrepreneurship?
Authors: Wahab Bashir Adelowo , Jibir Adamu , Abdu Musa
Published: October 2023

The need for promoting entrepreneurship stems from the efforts to provide long-lasting solutions to the challenges of poverty and unemployment. This becomes even more crucial in worldwide crises such as the COVID-19 pandemic. The COVID-19 pandemic has not only had a momentous effect on businesses and economies but has also driven us to recognize the importance of entrepreneurship. This study explores the combination of important entrepreneurial and household factors that drive the growth of new businesses during and after the crisis. This study applies the Round 2 data from the Nigeria National Longitudinal Phone Survey Phase 2 conducted by the National Bureau of Statistics in collaboration with the World Bank between November 2021 and August 2022. The logistic regression model analyzes how job loss due to the pandemic correlates with the probability of household heads starting and operating an enterprise immediately after the pandemic and the probability for the existing household entrepreneurs to innovate. The findings show that necessity-driven entrepreneurship became effective immediately after the COVID-19 pandemic in Nigeria, and innovation and opportunity recognition were more relevant as success factors during periods of crisis than during regular times. This is because the crisis produced a new set of highly competitive and strategic entrepreneurs that quickly adapted to new situations or conditions through their innovative capacity. Several policy recommendations derived from the study’s empirical findings are discussed in the conclusion section of the article.

JEL Classification

I1, D1, L26, F44, C35, N97
Psychodynamic practice in psychiatry
Authors: Korner Anthony
Published: October 2023

Objective

The aim is to identify and illustrate the place of psychodynamic practice and the therapeutic relationship in psychiatry, including consideration of the need for psychodynamic formulation and longer-term psychotherapies, in the context of debate over guidelines for depression management.

Conclusions

Effective psychiatric practice requires a working understanding of psychodynamic principles. Effective management planning is underpinned by psychodynamic formulation. A full range of therapeutic options need to be available for optimal care.
What Does Leaders’ Abuse Mean to Me? Psychological Empowerment as the Key Mechanism Explaining the Relationship Between Abusive Supervision and Taking Charge
Authors: Sun Ui Young , Xu Haoying , Kluemper Donald H. , Lu Xinxin , Yun Seokhwa
Published: October 2023

We integrate the cognitive theory of empowerment and regulatory focus theory to suggest that abusive supervision, from which employees draw negative achievement and security implications, discourages employees from engaging in taking charge by damaging their psychological empowerment. We propose that this negative influence is more saliently experienced by both promotion-focused and prevention-focused employees, albeit for different reasons. To test our model, we conducted a field study (Study 1) and a scenario-based experiment (Study 2). In Study 1, we found that psychological empowerment stood as a key mechanism linking abusive supervision and taking charge. Further, promotion focus magnified the negative effects of abusive supervision on psychological empowerment, and in turn, taking charge. Yet, prevention focus did not influence these effects. In Study 2, we replicated these findings and revealed that the anticipations of both career success and job insecurity (representing employees’ achievement and security implications) are critical in linking abusive supervision and psychological empowerment. We also found that promotion focus strengthened the negative indirect effect of abusive supervision on psychological empowerment via anticipated career success, ultimately resulting in a greater negative impact on taking charge. As in Study 1, there was limited support for the moderating effects of prevention focus. Our research highlights the importance of adopting a cognitive view in understanding the impact of abusive supervision on employees’ taking charge.
The Tolerability and Safety of Psilocybin in Psychiatric and Substance-Dependence Conditions: A Systematic Review
Authors: Kaminski Dana , Reinert Justin P.
Published: October 2023

Objective:

The objective of this systematic review is to determine the tolerability and safety of psilocybin in a variety of psychiatric and substance-dependence conditions.

Data sources:

A systematic review was conducted using Embase, PubMed, Cochrane Central, and Web of Science through September 2023 using the following terminology: “psilocybin” AND “mental-disease” OR “substance-dependence” AND “disease-therapy,” in addition to other synonymous key words.

Study selection and data extraction:

Literature reporting acute effects and safety data following the use of psilocybin as the pharmacologic intervention in a clinical trial in adult patients with a psychiatric or substance-dependence condition were included. Following the application of inclusion and exclusion criteria, 16 studies were ultimately included in this review.

Data synthesis:

The most common treatment-emergent adverse effects reported were transient nausea and headache. Transient anxiety was reported as a frequent psychiatric effect, and 3 participants received a benzodiazepine for refractory anxiety during the psilocybin session. Psilocybin demonstrated modest increases in blood pressure and heart rate, and 1 participant received an antihypertensive for sustained hypertension during the psilocybin session. No cases of psilocybin-induced psychosis or Hallucinogen Persisting Perception Disorder were reported.

Relevance to patient care and clinical practice:

Treatment resistance remains a concern for psychiatric patients and novel therapies are needed to help alleviate the burden of morbidity and mortality. Psilocybin demonstrates promising acute and long-term safety that may allow for its use in psychiatric or substance-dependence conditions as an alternative to standards of care or in treatment-resistant patients.

Conclusions:

Psilocybin has demonstrated tolerability and safety in recent literature that has investigated its therapeutic potential in a variety of psychiatric or substance-dependence conditions.
Teaching in the Age of AI/ChatGPT in Mental-Health-Related Fields
Authors: Rajaei Afarin
Published: October 2023

In recent years, the fusion of Artificial Intelligence (AI) with traditional sectors has catalyzed a paradigm shift that extends beyond technological advancements and reaches into the core of human learning and development. One such domain undergoing significant transformation is mental health education. This short conceptual paper seeks to examine the intricate relationship between AI and education in the context of mental health studies, shedding light on the challenges, opportunities, and ethical considerations that arise as teaching evolves in the Age of AI. This paper is not intended to serve as THE definitive solution to inquiries regarding the integration of AI/ChatGPT in mental health education. Rather, its purpose is to provide AN approach to contemplating this matter and to initiate further discussions within mental health-related fields about the utilization of AI and ChatGPT in education, given the persistent prominence of AI.
Solitary Fibrous Tumor of Breast and Axilla: Clinicopathological Profile of Five Tumors With Comparison of Risk Stratification Models
Authors: Hoda Raza S. , Duckworth Lauren A. , Gilmore Hannah L. , Cui Xiaoyan , McIntire Patrick J. , Sciallis Andrew P. , Van Arnam John S. , Zhang Gloria , Rowe J. Jordi , Xiao Huijun , Azzato Elizabeth M. , Goldblum John R. , Fritchie Karen , Downs Erinn P.
Published: October 2023

Introduction: Solitary fibrous tumor (SFT) is a fibroblastic tumor with malignant potential that is underpinned by a recurrent inv12(q13q13)-derived NAB2::STAT6 fusion. Breast and axilla are uncommon locations for this entity. Methods: Records of two academic institutions were electronically searched for breast and axillary SFTs. Clinical and pathologic data were reviewed. Literature review for breast or axillary SFTs was performed. Present study and previously reported tumors were stratified using five SFT risk models: original and modified Demicco metastatic risk, Salas local recurrence risk, Salas metastatic risk, and Thompson local recurrence risk. Results: Five patients with breast or axillary SFT were identified. Median age was 49 years, and median follow-up (available for four patients) was 82 months. Three patients showed no evidence of disease, and one developed recurrence. Literature review identified 58 patients with breast or axillary SFT. Median age was 54 years, and median follow-up (available for 35 patients) was 24 months. Thirty-one patients showed no evidence of disease, three developed recurrence, and one developed metastasis. Original and modified Demicco models and Thompson model showed the highest sensitivity; original and modified Demicco models and Salas metastatic risk model demonstrated the highest specificity. Kaplan–Meier models were used to assess recurrence-free probability (RFP). Original and modified Demicco models predicted RFP when stratified by “low risk” and “moderate/intermediate and high risk” tumor, though sample size was small. Conclusions: While many SFTs of breast and axilla remain indolent, a subset may develop recurrence and rarely metastasize. The modified Demicco risk model demonstrated optimal performance characteristics.
Thoracic SMARCA4-Deficient Undifferentiated Tumors With Unusual Presentations: A Case Series
Authors: Helmink Austin J. , Alshomrani Ahmad , Lauer Scott R. , Yuil-Valdes Ana
Published: October 2023

Context

Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a recently described aggressive neoplasm of young smokers defined by SMARCA4 inactivating mutations and characterized by cells with rhabdoid morphology, high mitotic activity, and abundant necrosis.

Objective

Describe and compare 3 unusual presentations of SMARCA4-UT in older adults, including one presenting as a metastatic lesion mimicking a primary bone sarcoma. Discuss the molecular characteristics of SMARCA4-UT and their relationship to nonsmall-cell lung carcinomas with SMARCA4.

Design

Three patients with SMARCA4-UTs were identified utilizing a natural language search in CoPath. hematoxylin and eosin sections from all patients as well as Papanicolaou-stained slides and Diff-Quik-stained slides for the first patient were examined. A broad range of immunostains, including BRG1/SMARCA4, were evaluated. Molecular testing was performed via next-generation sequencing.

Results

The 3 patients were aged 58, 70, and 70 years. All had a significant smoking history. The first patient presented with an iliac bone mass and mediastinal lymphadenopathy, the second with mediastinal adenopathy, and the third with a paratracheal mass. All 3 tumors showed a diffuse proliferation of pleomorphic, rhabdoid cells with high mitotic activity and tumor necrosis. SMARCA4 was lost in all 3 tumors by immunohistochemistry. Molecular testing revealed SMARCA4 alterations in the first 2.

Conclusions

Thoracic SMARCA4-UT should be considered in the differential diagnosis of pleomorphic rhabdoid tumors in older adults with a smoking history. Although most present as lung and/or mediastinal masses, they may occasionally present as a metastasis and mimic an undifferentiated sarcoma, representing a potential diagnostic pitfall.
Primary Undifferentiated Gallbladder Carcinoma With SMARCA4 Deletion: A Case Report and Review of the Literature
Authors: Xiaoxu Deng , Xianghong Yang
Published: October 2023

Background. Undifferentiated gallbladder carcinoma is a rare type of cancer with poor prognosis, due to the absence of specific clinical manifestations, and the final diagnosis depends on pathological and immunohistochemical examinations. However, only a few reports of SMARCA4-deficient undifferentiated gallbladder tumor have been published to date. Therefore, we report the diagnosis and treatment of an undifferentiated gallbladder carcinoma with SMARCA4 deficiency. Case Presentation. A 65-year-old woman with undifferentiated gallbladder carcinoma was treated using traditional Chinese medicine and underwent palliative surgery in our hospital. The postoperative pathology showed SMARCA4-deficient undifferentiated gallbladder carcinoma with metastasis to the abdominal lymph nodes. Conclusions. This case report contributes to the limited literature regarding undifferentiated carcinoma without SMARCA4 in the gallbladder.