bluuebunny/crossref_metadata_2025 huggingface dataset:
Single Document Summarization Based on Grey Wolf Optimization
Authors: Sartakhti Moein Salimi , Yoosofan Ahmad , Fatehi Ali Asghar , Rahimi Ali
Published: September 2021

The amazing growth of online services has caused an information explosion issue. Text summarisation is condensing the text into a small version and preserving its overall concept. Text summarisation is an important way to extract significant information from documents and offer that information to the user in an abbreviated form while preserving its major content. For human beings, it is very difficult to summarise large documents. To do this, this paper uses some sentence features and word features. These features assign scores to all the sentences. In this paper, we combine these features by Grey Wolf Optimiser (GWO). Optimisation of features gives better results than using individual features. This is the first attempt to show the performance of GWO for Persian text summarisation. The proposed method is compared with the genetic algorithm and the evolutionary strategy. The results show that our model will be useful in this research area.
 
Keywords: Text summarisation, genetic algorithm, sentence, score function, evolutionary strategy.
Gender differences in applicability of guidelines in clinical practice of heart failure patients
Authors: SOYDAN Elton , KAYIKÇIOĞLU Meral , PAYZIN Serdar
Published: September 2021

Aim: Treatment methods decreasing mortality in heart failure (HF) are provided in detail by updated guidelines. We aimed to provide true data in our department about the applicability of guidelines into clinical practice on management of HF patients and their follow-up status.

Materials and Methods: We retrospectively assessed the clinical data of patients hospitalized with HF between 2009 and 2010 in our hospital. All the collected data were used to assess the applicability of guidelines and follow-up status for a 5-year time period. A retrospective assessment was preferred in order to reflect the real clinical practice.

Results: There were 496 patients hospitalized for HF between January 2009 and January 2010. New onset and chronic HF were diagnosed in 24.4% and 75.6% respectively. The most common scenario of acute HF was pulmonary oedema (77%). Ischemic heart disease was the predominant etiology (49.2%). The median age of patients was 65.62±14.48 and 67.7% of them were male. HF therapies increased from admission to discharge, but decreased during follow-up. Median length of stay was 11.26±9.26 days and in hospital mortality 9.5%. The most common complication was infection (18.2%). During follow-up, hospitalization rate was 88.2% and long-term mortality 44.5%.

Conclusion: Patients with HF are far away from the cardiovascular prevention targets. The evidence-based therapy recommended by the guidelines was not sufficiently provided. The high rehospitalization and in hospital mortality rate was linked to high rate of pneumonia
Uso terapêutico de tecidos e órgãos humanos para transplantes: eventos adversos e ações de biovigilância
Authors: Treviso Patricia , Schirmer Janine , Mendes Karina Dal Sasso , Fernandes Sabrina Alves , Silveira Andresa Thomé , Roza Bartira De Aguiar
Published: September 2021

Objetivo: Identificar evidências na literatura sobre eventos adversos e ações de biovigilância no processo de doação e uso terapêutico de tecidos e órgãos humanos para transplante. Método: Revisão integrativa, utilizando as bases de dados LILACS, MEDLINE e Embase. Critérios de inclusão: estudos primários em inglês, espanhol e português, publicados entre 2015 a 2021, acerca da biovigilância na doação e transplante, riscos e eventos adversos. Resultados: Analisados 10 artigos, identificando a ocorrência de eventos adversos referentes ao processo de doação e transplante e estratégias de biovigilância para reduzir riscos e aumentar a segurança. Conclusão: Riscos e eventos adversos podem ocorrer no processo de doação e transplante. Observaram-se estratégias, para mitigar os riscos e a ocorrência/recorrência de eventos adversos, propiciando maior qualidade assistencial e segurança ao paciente. O enfermeiro tem papel fundamental no que concerne à biovigilância, estando presente em todas as fases do processo de doação e transplante.
Stigma among Physicians Towards Patients with Mental Health Disorders
Authors: Novais Filipa , Telles-Correia Diogo
Published: September 2021

N/a.
Da igreja à pirâmide
Authors: Rostas Susanna
Published: September 2021

Algum tempo depois de terem chegado à Cidade do México no início do século XX, os Concheros envolveram-se gradualmente no crescente interesse cultural pelo passado asteca. Nas últimas décadas, porém, encontraram-se em uma situação antagônica com dançarinos que, embora executassem as mesmas danças, abraçaram uma forte ideologia neo-nacionalista e neo-indio - a mexicanidad. Os mexicas rejeitam o colonialismo espanhol e descartaram as práticas rituais claramente católicas dos Concheros, que dançam habitualmente fora das Igrejas. A preferência dos mexica se volta às pirâmides. O artigo examina, utilizando dados históricos e de trabalho de campo, o uso crescente de sítios arqueológicos, uma vez que esses foram lentamente renovados, concentrando-se em dois: Teotihuacan e Cholula. É importante ressaltar que, nas últimas duas décadas, uma aproximação gradual entre os Concheros e os Mexica tem ocorrido e o ethos global tem se transformado uma vez mais.
Desafiando a hegemonia religiosa
Authors: Petrova Zornitsa
Published: September 2021

Este artigo aplica o marco teórico do mercado religioso para examinar a paisagem religiosa da Lituânia como um campo hegemônico em que o catolicismo dominantes é considerado parte integrante da identidade nacional. O interesse de pesquisa visa explorar o movimento etno-pagão Romuva e suas estratégias para atuar contra a autoridade social da Igreja Católica e construir legitimidade por meio da maximização de capital cultural. Proponho a hipótese de que a forma ritualizada de celebração da festa da primavera Joré poderia ser considerada uma tentativa de construir uma narrativa de identidade alternativa e contra-hegemônia, que retrata uma visão de mundo em que aspectos éticos, culturais, naturais e políticos da realidade lituânia são reunídos para se formar uma unidade integral sob a orientação da religião etno-pagã.
"Buscando espiritualmente os Mayas"
Authors: Castañeda Quetzil E. , Castañeda Quetzil E.
Published: September 2021

Este artigo é um ensaio teórico que oferece uma abordagem ao estudo da busca espiritual da Nova Era em geral e, em particular, ao estudo do espiritualismo maia da Nova Era. O marco teórico da “busca espiritual” e do “cultic milieu” tem sido especialmente produtivo no que diz respeito à relação entre emergentes tecnologias espirituais de subjetividade, formas de modernidade e lógicas capitalistas de consumismo. No entanto, este artigo identifica deficiências nesse paradigma de pesquisa: ele não fornece o enfoque analítico ou as ferramentas conceituais para a compreensão da busca da espiritualidade por meio da alteridade de outras culturas e comunidades marcadas pela diferença étnico-racial. Este artigo aborda o uso contraditório e confuso do termo “Maia” como ponto de entrada para ilustrar a necessidade de se atentar aos processos transculturais e as políticas de transculturação. A partir de trabalhos estabelecidos na sociologia da religião sobre tipologias de cultos, ofereço critérios para se criar um marco analítico de tipos ideias que podem tanto começar a abordar questões de política, intercâmbio transcultural e dinâmica busca/comunidade, como permitir a realização de comparações e contrastes produtivos de diferentes espiritualidade e religiosidades emergentes nas Américas e em outros lugares. São apresentados os primeiros passos para o desenvolvimento deste marco de tipos ideias ao refletir sobre as questões referentes ao estabelecimento da busca espiritual maia da Nova Era como objeto de estudo.
The cultural effects of neo-paganism’s ritual creativity
Authors: De la Torre Renée , Gutiérrez Zúñiga Cristina , Dansac Yael
Published: September 2021

In the last fifty years, different spiritual movements—that do not correspond to the church model and that—have emerged, due to their fluid and dynamic character, have propitiated an advance of global networks and have contributed to making specialized frontiers increasingly porous and permeable fields. A range of practices and beliefs related to Neo-paganism, New Age, and neo-Indianisms/neo-ethnicities have thus emerged. These three spiritual modalities are inscribed in differentiable ideologies that intertwine the spiritual, the therapeutic, the political and the identity. They concur in a search for bodily knowledge and techniques that recover the spiritual meaning of life as a way out of the materialism of the consumer culture in force in these times. However, they also have different emphases that distinguish them, although they are constantly intertwined and often share common elements and can even be practiced in the same ceremony.
DEPOSITION OF Al/SnAl OHMIC CONTACT ON SILICON FROM A LIQUID PHASE
Authors: Tsybulenko Vadym V. , Shutov Stanislav V. , Boskin Oleg O.
Published: September 2021

Background. Single- and multi-layer metal films are widely utilized in modern electronics and optoelectronics as ohmic contacts. As a rule, the films are deposited by thermal evaporation, ion sputtering and chemical vapour deposition. However the methods of deposition from a liquid phase are the most simple and cost-effective. Thus the ohmic contact deposition by these methods is still an actual problem.
Objective. The purpose of the paper is to study the possibility of deposition of multi-layer ohmic metal films over a semiconductor wafer surface from a liquid phase, particularly by scanning liquid phase epitaxy technique.
Methods. In this work we considered the influence of a long-term temperature gradient at the interface metallic solution-melt – semiconductor wafer on the possibility of deposition of multi-layer ohmic metal films on the semiconductor wafer surface during segmental contact between the solution-melt and the wafer. For this purpose we carried out the simulation of heat transport process, wafer wetting process as well as the process of wafer cleansing off the solution-melt taking into account capillary phenomena in the mask openings using the method of scanning liquid phase epitaxy. For experimental confirmation of adequacy of the model proposed we carried out the deposition of Al/SnAl layer on silicon wafer in the above mentioned conditions.
Results. We have deposited the contact layer Al/SnAl on the surface of silicon wafer from Al-Sn solution-melt by scanning liquid phase epitaxy technique using supplementary heater for the wafer and mask installed in the apparatus. The contact layer is made as three identical pads located at different distance one from each other. By the analysis of current-voltage characteristic we determined that the metallic film contact with the semiconductor is a non-rectifying, i.e. ohmic contact. The specific contact resistance was determined by the Transmission Line Method using linear configuration of the contact pads (LTLM). Its value was 7.2∙10-4 Ohm·cm2.
Conclusions. The principal possibility of obtaining of multi-layer ohmic contacts to the semiconductor by scanning liquid phase epitaxy technique in conditions of segmental contact between the solution-melt and the wafer as well as long-term gradient at the contact interface was shown. The conditions were realized by using extra heating of the wafer back side and the high-temperature mask through which the solution-melt contacted the wafer.
SORTING APPROACHES IN THE HEURISTIC BASED ON REMAINING AVAILABLE AND PROCESSING PERIODS TO MINIMIZE TOTAL WEIGHTED TARDINESS IN PROGRESSIVE IDLING-FREE 1-MACHINE PREEMPTIVE SCHEDULING
Authors: Romanuke Vadym V.
Published: September 2021

Background. In preemptive job scheduling, total weighted tardiness minimization is commonly reduced to solving a combinatorial problem, which becomes practically intractable as the number of jobs and the numbers of their processing periods increase. To cope with this challenge, heuristics are used. A heuristic, in which the decisive ratio is the weighted reciprocal of the maximum of a pair of the remaining processing period and remaining available period, is closely the best one. However, the heuristic may produce schedules of a few jobs whose total weighted tardiness is enormously huge compared to the real minimum. Therefore, this heuristic needs further improvements, one of which already exists for jobs without priority weights with a sorting approach where remaining processing periods are minimized. Three other sorting approaches still can outperform it, but such exceptions are quite rare.
Objective. The goal is to determine the influence of the four sorting approaches and try to select the best one in the case where jobs have their priority weights. The heuristic will be applied to tight-tardy progressive idling-free 1-machine preemptive scheduling, where the release dates are given in ascending order starting from 1 to the number of jobs, and the due dates are tightly set after the release dates.
Methods. To achieve the said goal, a computational study is carried out with applying each of the four heuristic approaches to minimize total weighted tardiness. For this, two series of 4151500 scheduling problems are generated. In the solution of a scheduling problem, a sorting approach can “win” solely or “win” in a group of approaches, producing the heuristically minimal total weighted tardiness. In each series, the distributions of sole-and-group “wins” are ascertained.
Results. The sole “wins” and non-whole-group “wins” are rare: the four sorting approaches produce schedules with the same total weighted tardiness in over 98.39 % of scheduling problems. Although the influence of these approaches is different, it is therefore not really significant. Each of the sorting approaches has heavy disadvantages leading sometimes to gigantic inaccuracies, although they occur rarely. When the inaccuracy occurs to be more than 30 %, this implies that 3 to 9 jobs are scheduled.
Conclusions. Unlike the case when jobs do not have their priority weights, it is impossible to select the best sorting approach for the case with job priority weights. Instead, a hyper-heuristic comprising the sorting approaches (i. e., the whole group, where each sorting is applied) may be constructed. If a parallelization can be used to process two or even four sorting routines simultaneously, the computation time will not be significantly affected.
MODELLING APPROACH IN THE DEVELOPMENT OF ELECTROCHEMICAL 3D-PRINTING SYSTEMS
Authors: Vasiliev Georgyi S. , Ushchapovskyi Dmytro Yu. , Vorobyova Victoria I. , Linyucheva Olga V.
Published: September 2021

Background. New 3D-printing technologies are becoming more and more advanced and widespread in the twenty-first century. One of the types of 3D-printing is electrochemical 3D-printing, in which electrochemical deposition of metals is used to form metal products. Potentially, this method of 3D-printing is the most energy efficient, the least material-intensive, and also the easiest to implement. There- fore, research aimed at creating and improving systems for electrochemical 3D-printing is promising.
Objective. The aim of the paper is to study the influence of geometric parameters of the system and the composition of the elec trolyte on the current distribution on the surface of the working electrode (cathode) in the process of electrochemical 3D-printing, and therefore print accuracy.
Methods. Volt-amperometric measurements and multi-physical computer modelling of the secondary distribution of current density using COMSOL MULTYPHYSICS for different geometric parameters of the working part of the 3D-printer and different composition of electrolytes.
Results. Based on the simulation of the secondary distribution of current density in copper sulphate electrolyte, it was found that the content of sulfuric acid in the solution should be minimal in order to purposefully deposit metal in the area directly under the working electrode. Based on the condition of maximum energy efficiency and accuracy of electrochemical 3D-printing, the optimal ratio between the deposition surface (cathode) and the edge of the non-conductive body of working electrode was found.
Conclusions. It was established that in order to narrow the zone of current scattering (increase the accuracy of electrochemical 3D-printing) it is necessary to ensure the optimal ratio between the diameter of the capillary and the edge of the non-conductive body of the counter electrode. It was shown that this ratio should not be less than 5 [mm / mm]. Further applied research will be aimed at adaptation and practical implementation of the obtained model data, optimization of the electrolyte composition and design of the 3D-printer.
Comparison of efficacy and modes of action of two high-potential biocontrol Bacillus strains and commercial biocontrol products against Botrytis cinerea in table grapes
Authors: Calvo Héctor , Roudet Jean , Gracia Ana Pilar , Venturini María Eugenia , Fermaud Marc
Published: September 2021

In table grapes (cv. Thomson Seedless), the antifungal activity against Botrytis cinerea was further analysed and compared between two high potential bacterial biological control agent (BCA) strains, Bacillus velezensis BUZ-14 and B. ginsengihumi S38. Two commercial biocontrol products (BPs), served as standards of comparison, Amylo-X® and Serenade Max®, also based on Bacillus BCA strains. The main mode of action quantified for all the strains was antibiosis due to hydrosoluble and volatile metabolites and their combinations. The BUZ-14 strain was the most active BCA strain, demonstrating significant disease reduction exceeding 60 % when used in the culture form grown in 863 medium, including living cells (LCs) and cell-free supernatant (CFS). Both BPs exhibited significantly reduced efficacy of their CFS fraction (< 10 %) compared with that of the two BCA strains, confirming their high antibiosis potential. The novel methodology allowed us to demonstrate the significant effect of the BCA culture medium on volatilome (VOC) antagonist efficacy. The S38 strain achieved the highest disease reduction (90 %) owing to the greatest production of VOCs in the richest MOLP (Medium Optimum Lipopetide Production) culture medium, whereas grape juice was the least favourable medium for VOC efficacy for both bacterial strains (BUZ14 and S38). The overall poor activity of living Bacillus cells in all the BCA and BPs tested is discussed based on the low capacity of the BCA strains to grow in the berry. Then, the presence of living cells is also discussed with the possibility that these cells are not required in field applications of such BCA strains in this genus. Moreover, different environmental suboptimal conditions, including temperature (22 and 27 °C) and relative humidity (RH) (100 and 85–95 %), were tested, and BUZ-14 exhibited the highest Botrytis reduction at both temperatures and RH values. However, no significant differences were observed between temperatures or RH values for the same BCA. Further studies in vineyard conditions and applications, such as biofumigation or active packaging, will be performed to confirm the new findings reported in this investigation.
Antithrombotic Management for Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
Authors: Panov A. V.
Published: September 2021

Comprehensive protection of a patient with atrial fibrillation (AF) should not only reduce the risk of stroke and systemic embolism, but also reduce the risk coronary events and ensure high adherence to treatment. In accordance with consensus document issued by the European Heart Rhythm Association, European Society of Cardiology, European Association of Percutaneous Cardiovascular Interventions, as well as with other recent Russian Society of Cardiology Guidelines, the management of antithrombotic therapy of patients with AF undergoing percutaneous coronary intervention (PCI) requires that multiple and interconnected issues. The review article addresses questions about duration of initial triple antithrombotic therapy (TAT), selection of P2Y12 inhibitor, choice of oral anticoagulant to be combined with antiplatelet therapy, intensity of oral anticoagulation throughout combination therapy, and choice of oral anticoagulant for indefinite therapy. In general, it is recommended to refuse the routine use of TAT for most patients. Accordingly, for patients who need both anticoagulant and antiplatelet therapy, it is strongly recommended that the default strategy after recent PCI is a double antithrombotic therapy consisting of an anticoagulant and one antiplatelet, preferably from the group of P2Y12 inhibitors. When conducting combined antithrombotic therapy, preference should be given to clopidogrel compared to other, more powerful P2Y12 inhibitors and direct oral anticoagulant (DOAC) instead of vitamin K antagonists. The primary choice of DOAC in patients with AF who have undergone PCI should be carried out taking into account such factors as individual risk of stroke and bleeding, adherence to treatment, concomitant diseases, pharmacological characteristics and evidence base of a specific DOAC, taking other medications, etc. The pharmacokinetic features of rivaroxaban, which create the possibility of its single administration, the evidence base for reducing coronary risks in various variants of the course of coronary heart disease, determines the special positions of the drug for the comprehensive protection of patients with AF after PCI.
The Questionnaire Survey Method in Medicine on the Example of Treatment Adherence Scales
Authors: Lukina Yu. V. , Kutishenko N. P. , Martsevich S. Yu. , Drapkina O. M.
Published: September 2021

Aim. Development, testing and validation of the original questionnaire “Adherence Scale” (AS) in the PRIORITY and ANTEY observational studies (OS).

Materials and methods. The OS PRIORITY assessed adherence to statins in 298 patients with high and very high cardiovascular risk for 3 months. The OS ANTEY assessed adherence to oral anticoagulants in 201 patients with non-valvular atrial fibrillation for 1 year. Adherence was assessed using the original AS questionnaire, for which external validation was performed (with the calculation of the Cohen's Kappa coefficient). The reference methods were the validated questionnaire and direct medical interview. And internal validation was performed (consistency of questions on the AS using Spearman's correlation analysis). The sensitivity, specificity (ROC analysis) and retest reliability of the adherence scale (Cronbach's alpha) were also determined.

Results. In the OS PRIORITY Cohen's kappa for the AS and the reference method of direct medical survey was 0.76 (high consistency), and for the AS and the reference method of the validated questionnaire=0.28 (low consistency). High internal consistency of the questionnaire questions (correlation coefficient=0.78, p<0.0001) confirms the internal validity of the adherence scale. Evaluation of the main characteristics of the modified AS in the OS ANTEY showed high consistency between the results of the AS and the validated questionnaire: Cohen's kappa=0.94 (high external validity of the AS). The retest reliability of the AS was 0.76 (Cronbach's alpha). The internal consistency of the questionnaire was confirmed by a strong and statistically significant correlation between the test questions: Spearman's correlation coefficient=0.80, p<0.0001. The sensitivity of the test, determined using the ROC analysis, was 89%, and the specificity was 62%.

Conclusion. The developed and tested new original questionnaire (modified version) – the AS – showed high indicators of reliability, validity and sensitivity. This ensures its reliability and ease of use for assessing various types of adherence and determining the leading factors of non-adherence, and also allows its use in scientific studies and clinical practice.
Inflammation and Comorbidity. Are There any Chances to Improve the Prognosis in Patients with Extremely High Cardiovascular Risk?
Authors: Zykov M. V. , Barbarash O. L.
Published: September 2021

The review contains actual data on possible approaches aimed at improving the prognosis in a special category of patients with extremely high cardiovascular risk, as well as in patients with recent acute coronary syndrome combined with comorbidity, including multifocal atherosclerosis. Currently, there are no class I recommendations for such patients aimed at reducing the risk of adverse cardiovascular events. It is suggested that suppression of inflammation may be a new therapeutic goal in this category of patients. Given the importance of inflammation in the development and course of atherosclerosis, in recent years there have been repeated attempts to influence the various components of the pro-inflammatory cascade involved in atherogenesis, but not all of them have been successful. Special attention is given to the anti-inflammatory effects of colchicine, a drug that can improve cardiovascular outcomes in patients with proven atherosclerosis. The review provides numerous pathogenetic and clinical evidence for the effectiveness of colchicine in patients with various manifestations of atherosclerosis. It is concluded that colchicine is the most promising anti-inflammatory drug that can improve the outcome of cardiovascular diseases. Thus, there is a need to initiate new clinical trial protocols aimed at studying the anti-inflammatory potential of this drug in patients with extreme cardiovascular risk.
Association of smoking with indicators of the structure and function of left ventricle of the heart in middle-aged men
Authors: Isaykina O. Yu. , Rozanov V. B. , Aleksandrov A. A. , Kotova M. B. , Isaykina M. A. , Drapkina O. M.
Published: September 2021

Aim. Evaluation of the association of smoking (status, intensity and duration) with indicators of the structure and function of the left ventricle of the heart in a sample of middle-aged men.

Material and methods. This study is part of a 32-year prospective cohort observation of men from childhood (11-12 years). 301 (30.0%) representatives of the original population sample aged 41-44 years were included in the study. The examination included a survey on intensity of smoking, anthropometry, measuring blood pressure, pulse rate, echocardiography, and blood lipid analysis.

Results. 301 men aged 41-44 included 92 (30.6%) men who had never smoked, 73 (24.3%) men smoked in the past and 136 (45.2%) men currently smoke. 75% of current smokers started smoking before age 19, of which 32.3% started smoking before age 15. The duration of smoking cessation among former smokers was 14.4 (12.5; 16.2) years. The average duration of smoking [average (95% confidence interval)] among former smokers was 14.4 (12.5; 16.2), for current smokers – 25.3 (24.6; 26.0) years. Current smoking was statistically significantly associated with higher mean values of the left ventricular myocardium mass (LVMM), the left ventricular myocardial mass index (LVMMI), the end-systolic and end-diastolic interventricular septum thickness (IVSTs/IVSTd), the end-systolic left ventricular posterior wall thickness (LVPWs), and the intensity and duration of current smoking were associated with higher values of the relative wall thickness of the left ventricle, the end-diastolic interventricular septum thickness, the end-systolic interventricular septum thickness, and with low values of the left ventricular stroke volume index (LV SVI). Multiple regression analysis showed that current smoking has an independent effect on the left ventricular myocardium mass, the left ventricular myocardial mass index and the end-diastolic interventricular septum thickness, and the duration and intensity of smoking has an effect on the index of the left ventricular stroke volume index.

Conclusion. Current smoking, duration and intensity in middle-aged men is associated with unfavorable changes in indicators of the structure and function of the left ventricle of the heart. Efforts for primary prevention of smoking should begin as early as childhood and continue into adolescence and young adulthood.
Novel Biomarkers of Endothelial Dysfunction in Cardiovascular Diseases
Authors: Abdurakhmanov Z. M. , Umarov B. Y. , Abdurakhmanov M. M.
Published: September 2021

The review analyzes the role of assessing the state of the endothelium in the onset and progression of cardiovascular diseases, stratification of their risks, since endothelial dysfunction (ED) is a crucial predictor of this pathologies. In this regard, this paper presents the modern understanding of the methods for assessing ED, presents the advantages and disadvantages of various techniques. Despite the fact that flow-mediated dilation is widely used as a classical method for studying endothelial function, this technique depends on the physiological state of sensory nerves and calcium-activated potassium channels, cardiac output. This review focuses on new biomarkers for ED such as endothelial microparticles, endoglin and endocan, and discusses the relevance of the criteria for their use in clinical practice. Based on current scientific advances, the authors concluded that among these three newest biomarkers, today, endocan can be considered a more informative and reliable cellular marker of ED. Moreover, the authors have shown that when measured separately, many of the studied classical circulating biomarkers do not provide reliable information about the state of the endothelium, since the endothelial function has a complex physiological nature which therefore raises the question of the advisability of considering a combination of classical and new biomarkers for improving the assessment of the endothelial state.
Evaluation of the Influence of CYP2C9* 2, CYP2C9*3 Gene Polymorphisms on the Efficacy and Safety of Postoperative Analgesia with Ketoprofen in Patients after Cardiac Surgery
Authors: Morozova T. E. , Shatsky D. A. , Shikh N. V. , Shikh E. V. , Andrushchyshina T. B. , Lukina M. V. , Kachanova A. A. , Sozaeva Zh. A. , Shuev G. N. , Denisenko N. P. , Grishina E. A. , Sychev D. A.
Published: September 2021

Aim. The aim of the study was to evaluate the efficacy and safety of ketoprofen as an analgesic therapy in patients with CYP2C9*2 (430C>T) rs179985 and CYP2C9*3 (1075A>C) rs1057910 gene polymorphisms after cardiac surgery.

Material and methods. The study included 90 patients. Postoperative analgesia was perfomed by ketoprofen 100 mg intramuscularly twice daily. The evaluation of pain was determined daily by Numeric Rating Scale for 5 days after cardiac surgery. The safety of ketoprofen was determined by assessing the severity of gastroenterological symptoms using the Gastrointestinal Symptom Rating Scale questionnaire and determining the frequency of episodes of acute kidney injury. The material for DNA was venous blood. To determine the single nucleotide genetic polymorphisms CYP2C9*2 (430C>T) rs179985 and CYP2C9*3 (1075A>C) rs1057910, the real-time polymerase chain reaction was used.

Results. In patients with the AA genotype of CYP2C9*3 polymorphism, the intensity of pain on the numeric rating scale scale (points) was significantly higher than in patients with the AC genotype: 7 [6; 8] vs 6 [5; 6] (р=0,003), 7 [6; 8] vs 6 [5; 6] (р=0,04), 6 [5; 7] vs 5 [4; 5] (р=0,04), 5 [3; 6] vs 3 [3; 4] points (р=0,02) on days 1, 2, 3 and 5 of the postoperative period, respectively. The severity of gastroenterological symptoms was higher in patients with a heterozygous CT genotype for the allelic variant CYP2C9*2 than in patients with a wild CС genotype and amounted to 19 [19; 22] vs 18 [16; 20] points, respectively, (p=0,04). The distribution of genotypes for CYP2C9*2 polymorphisms and CYP2C9*3 polymorphisms between the groups of acute renal injury did not differ significantly.

Conclusion. Associations of polymorphisms CYP2C9*3 with a lower intensity of pain syndrome and CYP2C9*2 with a greater severity of gastroenterological symptoms were revealed.
Effect of Direct Oral Anticoagulants for Ulcer Epithelization and Laser Doppler Flowmetry Parameters In Patients with Diabetic Foot Syndrome and Atrial Fibrillation
Authors: Petrov V. I. , Rogova N. V. , Кuzmina T. N. , Lishuta A. S.
Published: September 2021

Aim. To study changes in epithelialization of diabetic foot ulcers and parameters of laser Doppler flowmetry (LDF) in patients with diabetic foot syndrome (DFS) and atrial fibrillation (AF) during complex therapy with the addition of direct oral anticoagulants (DOAC).

Material and methods. An open-label comparative randomized study in parallel groups was performed. Patients with neuroischemic DFS and persistent FA without previous anticoagulant therapy were randomized into two groups: combination therapy for DFS and rivaroxaban (group 1; n=24) or combination therapy for DFS and dabigatran (group 2; n=22). Changes in local status in diabetic foot ulcers, coagulogram parameters and LDF were studied at 4 and 12 weeks.

Results. Complete epithelialization of diabetic foot ulcers after 12 weeks was found in 14 (58.3%) patients in group 1, and in 10 (45.4%) patients in group 2. Statistically significant improvements in LDF parameters were found in both groups in both groups: an increase in the microcirculation index by 53.5% (p=0.02), pulse wave by 124.0% (p=0.003), respiratory wave by 59.4% (p=0.007) was found in group 1. An increase in the microcirculation index by 48.5% (p=0.02), pulse wave by 73.1% (p=0.003), respiratory wave by 47.1% (p=0.03) were found in group 2.

Conclusion. Positive statistically significant changes in epithelialization of diabetic foot ulcers and LDF parameters were found in patients with DFS and AF during 12 weeks of complex therapy with the addition of DOACs (rivaroxaban and dabigatran). Further research for DOACs in DFS patients is needed.
Association of SCN5A gene polymorphism with dilated cardiomyopathy
Authors: Nikulina S. Yu. , Kuznetsova O. O. , Chernova A. A. , Matyushin G. V. , Gurazheva A. A. , Maksimov V. N.
Published: September 2021

Subjects and methods. The study included patients with IDC (group 1; n=111, 89.2% men, average age 51.7±9.7 years) and ICM (group 2; n=110, 91.5% men, average age 58.7±8.4 years). All patients (IDC and ICM) underwent coronary angiography. Based on the anamnesis data and instrumental studies, those patients who could be said to have no risk factors for the development of dilatation of the heart cavities were identified in the group 1. And those patients who were reliably diagnosed with coronary artery disease were in the group 2, that is, dilatation of the heart cavities is due to a previous myocardial infarction, existing angina pectoris. The control group (n=121, average age 53.6±4.8 years) included patients who had no manifestations of cardiovascular diseases. The patients underwent laboratory and instrumental studies, as well as molecular and genetic studies of the A/G polymorphism of the SCN5A gene (rs1805124).

Results. In the group with IDC 51.4% of patients were carriers of the common homozygous AA genotype, the heterozygous AG genotype-40.5%, and the rare homozygous GG genotype-8.1%. In the control group 63.3% of patients were identified as carriers of a homozygous genotype by a common allele, and 33.5% were carriers heterozygous genotype, and homozygous genotype for a rare allele – 3.2%. The analysis revealed a statistically significant decrease in the frequency of carrying the homozygous AA genotype in patients with IDC compared to the control group of the rs1805124 polymorphism of the SCN5A gene. In the group of patients with ICM, the А allele (69.5% vs. 80.1%, p=0.003) and the AA genotype (50.9% vs. 63.3%, p=0.030) were significantly less common than in the control group. The rare homozygous GG genotype was statically more common in patients with ICM compared to the control group (11.8% vs. 3.2%, p=0.004). Also, the G allele in the group of patients with ICM was detected statically significantly more often than in the control group (30.5% vs. 19.9%, p= 0.003).

Conclusion. The polymorphic locus rs1805124 of the SCN5A gene is associated with both IDC and ICM. Homozygous genotype AA and allele A are conditionally protective factors for the development of these conditions in men.
SPIRITUAL AND MORAL VALUE ORIENTATIONS AS A GUARANTEE OF PERSONALLY SIGNIFICANT QUALITIES OF STUDENT YOUTH
Authors: Kostyria Iryna , Filipenko Larysa
Published: September 2021

In the article it is studied out that the spiritual and moral value orientations education of students is becoming increasingly important. It is determined that the need to establish in education approaches that ensure a harmonious balance of moral and professional qualities of graduates of higher education institutions is emphasized in the strategic documents of education of Ukraine. The research emphasizes that the effectiveness of spiritual and moral education of future engineers is realized due to students' awareness of the essence of spiritual and moral value orientations, as well as stimulating the need for professional self–development of future professionals. The article describes the implementation of the author's special course “Spiritual and moral value orientations: ways of education” in the educational process of Kharkiv National Automobile and Road University.
A TECHNOLOGY TO IMPROVE PEDAGOCIG WORKERS’ PROFESSIONAL COMPETENCY UNDER QUALIFICATION IMPROVEMENT CONDITIONS
Authors: Gren Larysa , Panfilov Yurii , Eremenko Tatyana
Published: September 2021

The article discloses the essence of such notions as competency, professional competency, technology; it is proved that improvement of professional competency in pedagogic workers in the course of their qualification improvement occurs due to a technology, the constituents of which are lectures, seminar classes and trainings. The authors have determined considerable differences in methodologies on conducting laboratory and practical classes in nature sciences and humanities and sociology disciplines to attain the main goals of training, as well as the methodology of teaching juridical disciplines at higher education institutions. The importance of the attained knowledge in rendering socio-psychological and corrective services to students with special learning needs and its practical application in the higher education institutions’ practices has been researched; also, the efficiency of the described technology for the qualification improvement courses attendees in their further pedagogic activities has been proved.
PSYCHOLOGICAL AND PEDAGOGICAL ASPECTS OF DIAGNOSTICS TA SHLYAKHIV FORMUVANNYA VIDPOVIDALNOSTI SPECIFICATIONS MAYBUTNIKH FAKHIVTSIV
Authors: Stepanov Oleksiy , Venger Albina
Published: September 2021

The article studies the psychophysiological features of drivers and their impact on road safety. The levels of psychophysiological “danger” and psychological characteristics of drivers are studied based on the analysis of their professional activity. The individual psychological features of drivers caused by disorders of mental regulation of their behavior are determined. The authors propose to improve the system of psychological training of drivers, taking into account the factors of “dangerous driving”.
ICT MEANS IN THE FORMATION OF STUDENTS’ COGNITIVE INTERESTS IN MASTERING A FOREIGN LANGUAGE LEXICAL COMPETENCE
Authors: Bashkir Olga , Zolotukhina Svetlana
Published: September 2021

The problem of preparation of students of general secondary education institutions for mastering a foreign language in the conditions of blended learning is considered. The efficiency of using information and communication technologies of blended learning in the formation of cognitive interest of students to master foreign language lexical competence is determined and proved.
MATHEMATICAL FOUNDATIONS OF ADVANCED INFORMATICS: SPECIFICS OF TEACHING THE COURSE WITH UTILIZATION OF THE SYSTEM GRAN AND UTILIZATION FOR PARTICIPANT-DIRECTED LEARNING
Authors: Hrybiuk Olena
Published: September 2021

The article considers the issue of computer training of mathematics teachers in the context of using computer mathematics systems as a teaching tool. The analysis of propaedeutic tasks of the course “Mathematical foundations of Advanced Informatics” (MFAI) is carried out. The system of tasks is considered and situational tasks are analyzed with the use of rules-guidelines and methodical instructions for solving problems with the use of the GRAN system. An updated syllabus of the training course is offered taking into account modern requirements. The analysis of the logical-structural scheme of the training course “Mathematical foundations of Advanced Informatics” (MFAI) is considered. The main advantages of using the GRAN system are demonstrated. The results of the conducted pedagogical experiment using the computer mathematics system GRAN are offered. Criteria, indicators and methods of diagnosing the effectiveness of student learning are substantiated. The classification of problems is carried out and examples of didactic materials for teaching the course using computer mathematics systems GRAN are offered.
EXPERIMENTAL AND COMPUTATIONAL STUDY OF LIQUID OSCILLATION DAMPING IN A FREE SURFACE VESSEL
Authors: Kozhushko Andriy
Published: September 2021

Studying the issues related to solving the problems of the movement of fluid in partially filled structures of various shapes has always been relevant.This is due, in particular, to the need to ensure the longitudinal and lateral stability of the movement of objects in which the liquid is transported. Contemporarymethods and research tools that allow describing the movement of liquid in a container are overly complex and require in-depth knowledgefrom a scientist. Therefore, development of a mathematical algorithm that would be simple and at the same time ensure sufficient accuracy in determiningthe oscillatory motion in a container is advisable. Each development of a new mathematical algorithm requires experimental research to verifyits adequacy. The purpose of this work is to confirm the feasibility of using the created mathematical apparatus for determining the main parameters offree vibrations depending on the level of liquid in a rectangular prismatic container. The experimental research methodology provides for checking theadequacy of the mathematical algorithms in determining the frequencies of free oscillations of liquid in a container by comparing the theoretical andexperimental values of the oscillation periods, as well as determining the damping decrement of oscillations for liquids of different viscosity. As a result,the adequacy of the formulas for determining the frequencies of free oscillations of liquid in a container is proved; the maximum error does notexceed 4.35%. The decrements of vibration damping are determined experimentally, as well as using theoretical models of the motion of viscous liquidin the so-called partial surface layers, for three liquids of different viscosity, namely, for water, for 20% sugar and water solution, and for vegetable oil.On the basis of experimental studies, the amplitudes and frequencies of forced vibrations of various types of liquids are determined by constructing anamplitude-frequency characteristic. It is shown by calculation how the damping decrement of the liquid affects the value of the horizontal displacementof the surface layer of the liquid in the tank during its transportation by a wheeled tractor.
OSCILLATIONS DESCRIBED BY ANALOGUES OF VAN DER POL AND RAYLEIGH EQUATIONS
Authors: Olshanskiy Vasiliy , Olshanskiy Stanislav
Published: September 2021

The paper deals with the modes of steady-state quasilinear self-oscillations described by the analogues of Van der Pol and Rayleigh differential equations. The differential formulation of the energy balance method is applied for studying the motion. The conditions for the equations to describe quasilinear self-oscillations with the amplitude independent of the initial conditions are derived in the form of inequalities. The formulae for computing this amplitude using the table of gamma functions are proposed. The steady-state mode of the self-oscillations is proved to be stable in contrast to the static equilibrium which appears unstable. The inequalities are also obtained which guarantee the equations of the type considered to describe the damped free oscillations about the zero equilibrium or the oscillations which build up resulting in the loss of system stability. These forms of motion depend on the initial conditions. For small initial deflections, which are less than the threshold value, the oscillations decay whereas for large once they build up. The dynamical system, which is stable in small, is unstable in large. The impact of the constant component of the resistance force on the oscillatory process is also studied. It is shown to cause the shift of the position about which the steady-state self-oscillations occur but not to influence their amplitude or frequency, which is the result of the linear elasticity of the system. The special cases are separated, when the computational formulae proposed become the results previously known. The analytical studies are followed by numerical solution of the respective Cauchy problem. By comparing the results obtained by the two methods we substantiate the adequacy of the computational formulae obtained.
MODELING A DYNAMIC THREE-DIMENSIONAL BODY USING INTERFLATATION AND BLENDING APPROXIMATION
Authors: Pershyna Iuliia
Published: September 2021

The paper deals with the problem of reconstruction of the internal structure (density, absorption or attenuation coefficient) of a three-dimensional body by the information about it in the form of tomograms, given on a certain system of planes intersecting the object of study. This problem arises in practice in cases where there is no plane among the planes that are included in the experimental data, which consists of one or another set of points that are of interest to the researcher. For example, such a problem may arise after a patient has undergone examinations on a medical tomograph. After analyzing the obtained tomograms, it becomes necessary to find with their help one or more tomograms in the planes intersecting the body, but not coinciding with any of the given planes. It is noted that the operators of interflatation of functions is a natural generalization of the interpolation operators for the functions of three variables. Therefore, as in the case of interpolation, errors in the experimental data (in this case, in tomograms) are also introduced into the interflatation operators. In mathematics, there is an alternative to interpolation operators, namely approximation operators. These are operators constructed by smoothing experimental data using polynomials, rational functions, trigonometric polynomials, wavelets, and the like. An operator of mixed approximation of a function of three variables is constructed using Bernstein polynomials; the general form of the approximation error by the constructed operator and the estimate of this error are given. In the paper a four-dimensional mathematical model of a three-dimensional body that changes over time is also built and studied. A computational experiment is presented to restore the internal structure of the human heart from tomograms lying on a system of mutually perpendicular planes, which come from an actually operating computer tomograph. The article presents some possibilities of working with tomograms when restoring the internal structure of a three-dimensional body from the known projections of this body (tomograms).
Buku Ajar Business English
Authors: Santoso Dian Rahma
Published: September 2021

The author is grateful to write this guide book for English Education Study Program Faculty of Teacher Training and Education of Universitas MuhammadiyahSidoarjo. This book will be used for helping the students learn Business English I easier because it gives good understanding how to organize, manage and lead a business in simple ways. In addition, this book gives some simple dialogs that the students will like and apply easily for daily life and starting the business.