bluuebunny/crossref_metadata_2025 huggingface dataset:
Post-Transplant Cyclophosphamide versus Anti-Thymocyte Globulin in Patients with Hematological Malignancies Treated with Allogeneic Hematopoietic Stem Cell Transplantation from Haploidentical and Matched Unrelated Donors: A Real-Life Experience
Authors: Serio Bianca , Storti Gabriella , D’Addona Matteo , Santoro Lidia , Frieri Camilla , De Novellis Danilo , Marano Luana , De Santis Giovanna , Guariglia Roberto , Manfra Ilenia , Urciuoli Eleonora , Luponio Serena , Marotta Serena , Morini Denise , Rizzo Michela , Palmieri Fausto , Cantore Nicola , Giudice Valentina , Risitano Antonio Maria , Selleri Carmine
Published: April 2024

Background: Post-transplant cyclophosphamide (PTCY) is widely used as graft versus host disease (GvHD) prophylaxis in allogeneic hematopoietic stem cell transplant (HSCT) recipients, with reported clinical benefits in patients who underwent transplant from a matched unrelated donor (MUD). However, real-life data on clinical efficacy and safety of PTCY in haploidentical and MUD transplantations are still poor. Methods: In our real-life retrospective observational study, we included a total of 40 consecutive adult patients who underwent haploidentical or MUD HSCT for various hematological malignancies and who received PTCY (n = 24) or ATG (n = 16) as GvHD prophylaxis at Hematology Units from hospitals of Salerno and Avellino, Italy, and clinical outcomes were compared. Results: We showed protective effects of PTCY against disease relapse with the relapse rate after transplantation of 16% versus 50% in the ATG arm (p = 0.02). All-cause mortality was lower (36% vs. 75%; p = 0.02) and the 2-year overall survival was slightly superior in patients administered PTCY (61% vs. 42%; p = 0.26). Conclusions: We support the use of PTCY, even in a real-life setting; however, the optimization of this protocol should be further investigated to better balance relapse prevention and GvHD prophylaxis.
Bark Morphology and Nutrient Flux in Urban Trees: Investigating Water Absorption and Ion Concentration Dynamics
Authors: Lima Marcelle Teodoro , Guandique Manuel Enrique Gamero , Tonello Kelly Cristina
Published: April 2024

Urban trees play a pivotal role in mediating the hydrological and nutrient cycles within urban ecosystems, yet the mechanisms by which bark characteristics influence these processes remain underexplored. This study aimed to investigate the impact of the bark morphology—specifically texture, depth, and number of furrows—on the water absorption capacity and to determine the relationship between this capacity and ion concentration in stemflow across various urban tree species. Our findings reveal significant variations in water absorption and ion concentration related to the morphological traits of bark among tree species, highlighting the intricate relationship between bark physical and chemical characteristics and stemflow nutrient composition. Notably, species with furrowed textures, greater depth, and a higher number of furrows demonstrated pronounced differences in ion enrichment in their stemflow. However, a canonical redundancy analysis suggested a low association between bark absorption capacity and ion concentration, indicating the influence of other, possibly external, environmental factors on ion leaching. The results underscore the complexity of nutrient transport mechanisms in urban trees and show a new understanding of tree bark’s ecohydrological roles. This study contributes valuable insights into ecohydrology science and emphasizes the need for further research to unravel the multifaceted influences on nutrient dynamics in urban landscapes.
The Development of an Oral Health Nursing Tool for Patients with a Psychotic Disorder: A Human-Centred Design with a Feasibility Test
Authors: Kuipers Sonja , Castelein Stynke , Kronenberg Linda , Veer Job van ’t , Boonstra Nynke
Published: April 2024

Patients with psychotic disorders frequently report oral health problems, while mental health nurses (MHNs) seem not to be fully aware of these problems and the risk factors. Therefore, this study aimed to develop supportive tools for MHNs regarding oral health to increase sensitisation among MHNs and provide MHNs with the knowledge to recognise (potential) oral health problems in patients with a psychotic disorder. We used a human-centred design in which the user, MHNs and experts by experience were placed at the centre of the research process. Problems and needs in MHNs working with patients with a psychotic disorder were addressed. To identify key issues of problems as well as needs in terms of resources, we started with focus groups (n = 9). We analysed the data thematically based on the context of patients and MHNs in practice regarding oral health, preferred oral health tools focused on MHNs, and the intended outcomes of tools. A multi-criteria decision matrix was developed and analysed (n = 9) to identify the most optimal and viable solution based on established criteria and issues that are prevalent in the work of MHNs. The most promising result was the development of a brochure with an awareness screener. The brochure with the awareness screener was developed as a low-fidelity prototype for MHNs regarding oral health in patients with a psychotic disorder based on the latest scientific evidence. After testing it, the feasibility was tested through semi-structured interviews (n = 19). MHNs and experts by experience were satisfied with the tool and provided recommendations for adjustments to the content. Significant augmentations to the brochure included a clinical lesson and a toothbrush with toothpaste for patients. We can conclude that a brochure with an awareness screener is feasible for MHNs. Future steps aiming to further refine and optimise care processes for oral health tools in MHNs should take refining eligibility criteria for psychiatric populations and the language level of the target group of a tool into account.
Spatiotemporal Analysis of Water Body in the Chongming Island Region over the Past Decade Based on the ISUNet Model
Authors: Miao Lizhi , Feng Xinkai , Yang Lijun , Ren Yanhui , Deng Yamei , Hang Tian
Published: April 2024

Chongming Island and its surrounding areas are highly significant coastal regions in China. However, the regions undergo continuous changes owing to various factors, such as the sedimentation from the Yangtze River, human activities, and tidal movements. Chongming Island is part of the Yangtze River Delta, which is one of the most economically developed regions in China. Studying the water body changes in this area is of great importance for decision making in water resource conservation, coastal resource management, and ecological environmental protection. In this study, we propose an improved ISUNet model by enhancing the skip-connection operations in the traditional UNet architecture. We extracted and analyzed the water bodies in Chongming Island and its surrounding areas from 2013 to 2022, providing a detailed spatiotemporal analysis of the water body area over the years. The results indicate that the water body area in the study area has decreased by 267.8 km2 over the past decade, showing a gradually fluctuating downward trend with an average annual reduction of nearly 27 km2. The analysis suggests that the reduction in the water body area is mainly attributed to sedimentation near river channels and ports, the formation of sandbars owing to channel erosion, and the artificial construction of ports and coastal areas. The influencing factors include human activities and sedimentation from the Yangtze River Estuary. Specifically, human activities such as land reclamation, port construction, and aquaculture play a major role in causing changes in the area.
An Extensive Performance Comparison between Feature Reduction and Feature Selection Preprocessing Algorithms on Imbalanced Wide Data
Authors: Ramos-Pérez Ismael , Barbero-Aparicio José Antonio , Canepa-Oneto Antonio , Arnaiz-González Álvar , Maudes-Raedo Jesús
Published: April 2024

The most common preprocessing techniques used to deal with datasets having high dimensionality and a low number of instances—or wide data—are feature reduction (FR), feature selection (FS), and resampling. This study explores the use of FR and resampling techniques, expanding the limited comparisons between FR and filter FS methods in the existing literature, especially in the context of wide data. We compare the optimal outcomes from a previous comprehensive study of FS against new experiments conducted using FR methods. Two specific challenges associated with the use of FR are outlined in detail: finding FR methods that are compatible with wide data and the need for a reduction estimator of nonlinear approaches to process out-of-sample data. The experimental study compares 17 techniques, including supervised, unsupervised, linear, and nonlinear approaches, using 7 resampling strategies and 5 classifiers. The results demonstrate which configurations are optimal, according to their performance and computation time. Moreover, the best configuration—namely, k Nearest Neighbor (KNN) + the Maximal Margin Criterion (MMC) feature reducer with no resampling—is shown to outperform state-of-the-art algorithms.
Chatbot Design and Implementation: Towards an Operational Model for Chatbots
Authors: Skuridin Alexander , Wynn Martin
Published: April 2024

The recent past has witnessed a growing interest in technologies for creating chatbots. Advances in Large Language Models for natural language processing are underpinning rapid progress in chatbot development, and experts predict revolutionary changes in the labour market as many manual tasks are replaced by virtual assistants in a range of business functions. As the new technology becomes more accessible and advanced, more companies are exploring the possibilities of implementing virtual assistants to automate routine tasks and improve service. This article reports on qualitative inductive research undertaken within a chatbot development team operating in a major international enterprise. The findings identify critical success factors for chatbot projects, and a model is developed and validated to support the planning and implementation of chatbot projects. The presented model can serve as an exemplary guide for researchers and practitioners working in this field. It is flexible and applicable in a wide range of business contexts, linking strategic business goals with execution steps. It is particularly applicable for teams with no experience in chatbot implementation, reducing uncertainty and managing decisions and risks throughout the project lifecycle, thereby increasing the likelihood of project success.
From Sensing Technology towards Digital Twin in Applications
Authors: Zhu Jianxiong , Sun Bairong , Jia Luyu , Hu Haibing
Published: April 2024

Sensing technology drives innovation in digital technology, especially in data acquisition [...]
The Postoperative Paradoxical Septum (POPS): A Comprehensive Review on Physio-Pathological Mechanisms
Authors: Di Virgilio Emanuele , Basile Paolo , Carella Maria Cristina , Monitillo Francesco , Santoro Daniela , Latorre Michele Davide , D’Alessandro Silvia , Fusini Laura , Fazzari Fabio , Pontone Gianluca , Guaricci Andrea Igoren
Published: April 2024

The interventricular septum (IVS) is a core myocardial structure involved in biventricular coupling and performance. Physiologically, during systole, it moves symmetrically toward the center of the left ventricle (LV) and opposite during diastole. Several pathological conditions produce a reversal or paradoxical septal motion, such as after uncomplicated cardiac surgery (CS). The postoperative paradoxical septum (POPS) was observed in a high rate of cases, representing a unicum in the panorama of paradoxical septa as it does not induce significant ventricular morpho-functional alterations nor negative clinical impact. Although it was previously considered a postoperative event, evidence suggests that it might also appear during surgery and gradually resolve over time. The mechanism behind this phenomenon is still debated. In this article, we will provide a comprehensive review of the various theories generated over the past fifty years to explain its pathological basis. Finally, we will attempt to give a heuristic interpretation of the biventricular postoperative motion pattern based on the switch of the ventricular anchor points.
Real World Data from Catheter Ablation of Ventricular Tachycardias and Premature Ventricular Complexes in a Tertiary Care Center
Authors: Schlatzer Christian , Berg Jan , Duru Firat , Brunckhorst Corinna , Saguner Ardan M. , Haegeli Laurent M.
Published: April 2024

Background: Catheter ablation in patients with ventricular arrhythmias (VA), such as ventricular tachycardias (VT) or frequent premature ventricular complexes (PVC), is increasingly considered an effective and safe therapy when performed in experienced centers. This study sought to determine acute success rates and complication rates of ablation procedures for patients with VA in a Swiss tertiary care center. Methods: All patients who underwent ablation therapy for VT and PVC at the University Heart Center in Zurich, Switzerland, between March 2012 and April 2017 were included in this analysis. Results: A total of 120 patients underwent catheter ablation for VT and PVC (69 and 51, respectively). Seventy percent of patients were male, and the mean age was 55.3 years. The most common indication for ablation was high PVC burden (47.5%), followed by paroxysmal VT (38.3%), ICD shocks (23.3%), incessant VT (12.5%), electrical storm (7.5%), and syncope (3.3%). Acute success rates for VT and PVC ablations were 94.2% and 92.2%, respectively. Rates for complications (including major and minor) for VT and PVC were 10.1% and 7.8%, respectively. Complications occurred only in patients with structural heart disease; no complications were noted in structurally normal hearts. Conclusions: Our results suggest that catheter ablation for VT and PVC has high acute success rates with a reasonable risk for complications in the setting of tertiary care centers, comparable to those reported in other studies.
Non-Interventional Weight Changes Are Associated with Alterations in Serum Uric Acid Levels
Authors: Weinstein Shiri , Maor Elad , Bleier Jonathan , Kaplan Alon , Hod Tammy , Leibowitz Avshalom , Grossman Ehud , Shlomai Gadi
Published: April 2024

Background/Objectives: Serum uric acid is an established cardiovascular risk factor. Higher serum uric acid levels are associated with overweight and obesity. We assessed whether non-interventional weight changes affect serum uric acid levels. Methods: We performed a retrospective analysis of 19,193 participants referred to annual medical screening. Body mass index (BMI) and serum uric acid were measured annually. Subjects were divided into five groups according to changes in BMI between visits: large reduction (reduction of more than 5% in BMI), moderate reduction (reduction of more than 2.5% and 5% or less in BMI), unchanged (up to 2.5% change in BMI), moderate increase (increase of more than 2.5% and 5% or less in BMI), and large increase (increase of more than 5% in BMI). The primary outcome was serum uric acid level changes between visits. Results: A decrease in serum uric acid levels was evident as BMI decreased and an increase in serum uric acid levels was associated with an increase in BMI. The proportion of patients whose serum uric acid levels were increased by at least 10% between visits increased with the relative increase in BMI, while the proportion of patients whose serum uric acid levels were reduced by at least 10% decreased with the relative decrease in BMI. Conclusions: Non-interventional weight changes, even modest, are associated with significant alterations in serum uric acid levels. Our findings may aid in better risk stratification and the primary prevention of cardiovascular morbidity and mortality.
How Preoperative Closed Reduction and Time to Surgery Impact Postoperative Palmar Inclination in Distal Radius Fractures
Authors: Beyer Frank , Oppermann Johannes , Prasse Tobias , Müller Lars Peter , Eysel Peer , Bredow Jan
Published: April 2024

Background: The anatomical reconstruction of the wrist is the aim when treating distal radius fractures. Current literature on the importance of preoperative reduction in fractures that are treated operatively is limited. Methods: This study investigated the effect of the preoperative closed reduction of distal radius fractures on the day of trauma and the time to surgery on postoperative palmar inclination. A total of eighty patients (48 females and 32 males, mean age 55.6 years) were studied retrospectively. All patients were treated with an open reduction and internal fixation. The palmar inclination angle was measured using X-rays by two investigators, and the interobservers and pre- and post-reduction parameters were compared. Results: When the surgical management of closed distal radius fractures is required, neither initial repositioning nor a delay of up to 14 days to the surgical treatment influences postoperative palmar inclination. Conclusions: The significance of preoperative reduction of distal radius fractures without neurovascular or extensive soft tissue damage is limited and is not leading to improved outcomes. When surgery is about to be performed, surgeons should carefully consider if reduction is really vital preoperatively. Level of evidence: III.
The Impact of Augmented Renal Clearance on Vancomycin Pharmacokinetics and Pharmacodynamics in Critically Ill Patients
Authors: Tesfamariam Novel Solomon , Aboelezz Asma , Mahmoud Sherif Hanafy
Published: April 2024

Augmented renal clearance (ARC), defined as a creatinine clearance (CrCl) > 130 mL/min/1.73 m2, is observed in 30–65% of critically ill patients. When following standard dosage guidelines, patients with ARC often experience subtherapeutic vancomycin levels, resulting in treatment failure due to accelerated drug elimination. This review aims to explore ARC’s impact on vancomycin pharmacokinetics and pharmacodynamics (PK/PD) indices in ARC patients, seeking to identify an accurate dose adjustment method for this patient population. In September 2023, a comprehensive literature search was conducted on the MEDLINE and EMBASE databases to include all available studies providing information on the impact of ARC on vancomycin therapy in critically ill adults. Articles that studied the pediatric population and those with insufficient PK data were excluded. A total of 21 articles met the inclusion criteria. The findings revealed a positive correlation between CrCl and vancomycin clearance, indicating low serum concentrations. Therefore, upward dosing adjustments are necessary to improve treatment success. Younger age consistently emerged as a major contributor to ARC and vancomycin PK/PD alterations. This study summarizes the PK/PD alterations, current dosage recommendations and proposes preliminary recommendations on possible dosing approaches to decrease the risk of subtherapeutic exposure in this patient population.
Prevalence and Impact of Concomitant Atrial Fibrillation in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction
Authors: Shakeel Iqra , Sharma Harish , Hodson James , Iqbal Hamna , Tashfeen Rashna , Ludman Peter F. , Steeds Richard P. , Townend Jonathan N. , Doshi Sagar N. , Nadir M. Adnan
Published: April 2024

Background: Concomitant atrial fibrillation (AF) is associated with an adverse prognosis in patients with acute myocardial infarction (MI). However, it remains unclear whether this is due to a causal effect of AF or whether AF acts as a surrogate marker for comorbidities in this population. Furthermore, there are limited data on whether coronary artery disease distribution impacts the risk of developing AF. Methods: Consecutive patients admitted with acute MI and treated using percutaneous coronary intervention (PCI) at a single centre were retrospectively identified. Associations between AF and major adverse cardiac and cerebrovascular events (MACCEs) over a median of five years of follow-up were assessed using Cox regression, with adjustment for confounding factors performed using both multivariable modelling and a propensity-score-matched analysis. Results: AF was identified in N = 65/1000 (6.5%) of cases; these patients were significantly older (mean: 73 vs. 65 years, p < 0.001), with lower creatinine clearance (p < 0.001), and were more likely to have a history of cerebrovascular disease (p = 0.011) than those without AF. In addition, patients with AF had a greater propensity for left main stem (p = 0.001) or left circumflex artery (p = 0.004) involvement. Long-term MACCE rates were significantly higher in the AF group than in the non-AF group (50.8% vs. 34.2% at five years), yielding an unadjusted hazard ratio (HR) of 1.86 (95% CI: 1.32–2.64, p < 0.001). However, after adjustment for confounding factors, AF was no longer independently associated with MACCEs, either on multivariable (adjusted HR: 1.25, 95% CI: 0.81–1.92, p = 0.319) or propensity-score-matched (HR: 1.04, 95% CI: 0.59–1.82, p = 0.886) analyses. Conclusions: AF is observed in 6.5% of patients admitted with acute MI, and those with AF are more likely to have significant diseases involving left main or circumflex arteries. Although unadjusted MACCE rates were significantly higher in patients with AF, this effect was not found to remain significant after adjustment for comorbidities. As such, this study provided no evidence to suggest that AF is independently associated with MACCEs.
Positive Emotions in Family Caregivers of Alzheimer’s Disease Patients: Factors Associated with Gain in Caregiving from a Gender Perspective
Authors: Ponsoda José Manuel , Díaz Amelia
Published: April 2024

Background/Objectives: Gender differences in the variables of burden, anxiety, depression, and others associated with psychological distress have been found in studies on caregivers caring for a dependent relative, but a gender perspective is seldom used when analysing the positive aspects of caregiving. This study contributes to filling this gap by analysing gender differences in caregivers in a specific positive variable: gain. Methods: A cross-sectional design was used in a sample of 44 male and 96 female caregivers from Family Alzheimer Associations. Gender differences were analysed in demographic and psychological variables associated with the caregiving situation. Results: Female caregivers showed higher psychological distress than male caregivers, but gender differences in gain were only obvious when a deeper analysis of the GAIN scale responses was performed. The mediational role of psychological distress and other predictive variables showed a different pattern in male and female caregivers. The important predictive and mediating role that psychological distress plays in the greater perception of gains in caregiving and the result showing that female caregivers are the ones with poorer mental health support the need for preventive and therapeutic programs specifically targeting the positive aspects of caregiving in female caregivers. Conclusions: Three aspects could be highlighted in this study: family caregivers of AD patients perceived gain in the caregiving situation; gender plays a differential role in the perception of gain; and, finally, psychological distress should be the target when interventions are planned, not only to alleviate negative aspects but also to increase the positive aspects of caregiving.
Concurrent Resistance and Cardiorespiratory Training in Patients with Hypertrophic Cardiomyopathy: A Pilot Study
Authors: Bayonas-Ruiz Adrián , Muñoz-Franco Francisca M. , Sabater-Molina María , Martínez-González-Moro Ignacio , Gimeno-Blanes Juan Ramon , Bonacasa Bárbara
Published: April 2024

Background: Exercise training in patients with HCM has evidenced benefits on functional capacity, cardiac function, and a reversion of adverse cardiac remodeling. The objective of this study was to assess the effect of a concurrent resistance and cardiorespiratory training program on functional capacity, biochemical parameters, and echocardiographic variables in a pilot group. Methods: Two HCM patients were evaluated before and after 12 weeks of individualized concurrent training with two sessions/week. Pre- and post-training data were compared for each patient. Evaluations included a cardiopulmonary exercise test (CPET), body composition, echocardiography, electrocardiography, and blood analysis. Results: Training promoted an increase in functional capacity (+4 mL·kg−1·min−1), ventilatory thresholds, and other CPET-derived variables associated with a better prognosis and long-term survival. Muscular mass was augmented (0.8 and 1.2 kg), along with a mean increase of 62% in upper and lower body strength. Echocardiographic features demonstrated the maintenance of cardiac function with signs of positive left ventricular remodeling and an improvement in diastolic function. Blood analyses, including cardiac troponins and NT-proBNP, displayed uneven changes in each patient, but the values fell into normal ranges in both cases. Conclusions: The available data suggest a positive effect of concurrent resistance and cardiorespiratory training on patients’ functional capacity and cardiac function that may improve their functional class, quality of life, and long-term prognosis. The replication of this protocol in a larger cohort of patients is warranted to confirm these preliminary results.
Where Do We Stand on Cervical Spine Immobilisation? A Questionnaire among Prehospital Staff
Authors: Gräff Pascal , Bolduan Lisa , Macke Christian , Clausen Jan-Dierk , Sehmisch Stephan , Winkelmann Marcel
Published: April 2024

Background: Cervical collars (CC) are routinely used in prehospital trauma treatment. However, over the past years, their application was discussed more critically since they increase intravenous pressure due to reduced venous drainage and the possibility of secondary cervical spine injury. Guidelines have been adjusted accordingly. The question is how efficient has this been put into practice, and how good, as well as up to date, is the knowledge of prehospital emergency medicine personnel about indications on cervical spine immobilisation? Methods: A 15-item questionnaire regarding the self-evaluation and result checking of the right indications for the use of a cervical collar in the prehospital setting was sent to paramedics and emergency doctors in Germany. Two hundred and nineteen completed surveys were statistically analysed. Results: Mean age of the participants was 30.45 ± 8.8. 72% were male. Regarding subjective safety, the appropriate indication of CC participants reached 79.8 ± 19.5 on a metric scale from 0 (no safety) to 100 (full safety). Mean right answers were as follows: Ambulance man (RS) 0.78 ± 0.84, paramedic (RA) 0.9 ± 0.74, paramedic (NFS) 1.03 ± 0.83 and emergency doctor (ED) 1.75 ± 1.06 (p = 0.013, Kruskal–Wallis Test). Participants who estimated their knowledge < 85% had 0.83 ± 0.8 right answers, and > 85% had 1.14 ± 0.9 right answers. Conclusions: Rational spine immobilisation is still necessary in severely injured patients. This study highlights the importance of continuing education using ongoing training, lectures or online learning with a questionnaire as a monitor for success to ensure the transfer of evidence-based medicine into daily practice.
Post-Keratoplasty Microbial Keratitis in the Era of Lamellar Transplants—A Comprehensive Review
Authors: Przybek-Skrzypecka Joanna , Samelska Katarzyna , Ordon Agata Joanna , Skrzypecki Janusz , Izdebska Justyna , Kołątaj Marta , Szaflik Jacek P.
Published: April 2024

Microbial keratitis in a post-transplant cornea should be considered a distinct entity from microbial keratitis in a non-transplant cornea. Firstly, the use of immunosuppressive treatments and sutures in corneal transplants changes the etiology of keratitis. Secondly, corneal transplant has an impact on corneal biomechanics and structure, which facilitates the spread of infection. Finally, the emergence of lamellar transplants has introduced a new form of keratitis known as interface keratitis. Given these factors, there is a clear need to update our understanding of and management strategies for microbial keratitis following corneal transplantation, especially in the era of lamellar transplants. To address this, a comprehensive review is provided, covering the incidence, risk factors, causes, and timing of microbial keratitis, as well as both clinical and surgical management approaches for its treatment in cases of penetrating and lamellar corneal transplants.
Strontium-Doped Bioglass-Laden Gelatin Methacryloyl Hydrogels for Vital Pulp Therapy
Authors: Aminmansour Sepideh , Gomes de Carvalho Ana Beatriz , Medeiros Cardoso Lais , Anselmi Caroline , Rahimnejad Maedeh , Dal-Fabbro Renan , Benavides Erika , Campos Tiago Moreira Bastos , Borges Alexandre Luiz Souto , Bottino Marco C.
Published: April 2024

This study aimed to develop gelatin methacryloyl (GelMA)-injectable hydrogels incorporated with 58S bioactive glass/BG-doped with strontium for vital pulp therapy applications. GelMA hydrogels containing 0% (control), 5%, 10%, and 20% BG (w/v) were prepared. Their morphological and chemical properties were evaluated by scanning electron microscopy/SEM, energy dispersive spectroscopy/EDS, and Fourier transform infrared spectroscopy/FTIR (n = 3). Their swelling capacity and degradation ratio were also measured (n = 4). Cell viability (n = 8), mineralized matrix formation, cell adhesion, and spreading (n = 6) on DPSCs were evaluated. Data were analyzed using ANOVA/post hoc tests (α = 5%). SEM and EDS characterization confirmed the incorporation of BG particles into the hydrogel matrix, showing GelMA’s (C, O) and BG’s (Si, Cl, Na, Sr) chemical elements. FTIR revealed the main chemical groups of GelMA and BG, as ~1000 cm−1 corresponds to Si-O and ~1440 cm−1 to C-H. All the formulations were degraded by day 12, with a lower degradation ratio observed for GelMA+BG20%. Increasing the concentration of BG resulted in a lower mass swelling ratio. Biologically, all the groups were compatible with cells (p > 0.6196), and cell adhesion increased over time, irrespective of BG concentration, indicating great biocompatibility. GelMA+BG5% demonstrated a higher deposition of mineral nodules over 21 days (p < 0.0001), evidencing the osteogenic potential of hydrogels. GelMA hydrogels incorporated with BG present great cytocompatibility, support cell adhesion, and have a clinically relevant degradation profile and suitable mineralization potential, supporting their therapeutic potential as promising biomaterials for pulp capping.
Contextualizing Positionality, Intersectionality, and Intelligence in the Anthropocene
Authors: Suzuki Lisa A. , Caso Taymy J. , Yucel Aysegul , Asad Ahad , Kokaze Haruka
Published: April 2024

The geological epoch of the Anthropocene has challenged traditional definitions of what intellectual abilities are necessary to creatively problem-solve, understand, and address contemporary societal and environmental crises. If we hope to make meaningful changes to how our society addresses these complex issues and pave the way for a better future for generations to come, we must advance traditional theories and measures of higher-order abilities to reflect equity and inclusion. To this end, we must address global issues by integrating the complexities of intersectional identities as they impact our understanding of what constitutes intelligence in individuals, groups, and diverse communities. This re-envisioning of intelligence presents new complexities for understanding and challenges for our field beyond the boundaries of what has been previously touted by many disciplines, including psychology. It is an opportunity to re-envision what it means to be intelligent in a diverse global context while also honoring and recognizing the value of difference, positionality, and other ways of knowing.
Gate-Level Hardware Priority Resolvers for Embedded Systems
Authors: Balasubramanian Padmanabhan , Maskell Douglas L.
Published: April 2024

An N-bit priority resolver having N inputs and N outputs functions as polling hardware in an embedded system, enabling access to a resource when multiple devices initiate access requests at its inputs which may be located on-chip or off-chip. Subsystems such as data buses, comparators, fixed- and floating-point arithmetic units, interconnection network routers, etc., utilize the priority resolver function. In the literature, there are many transistor-level designs for the priority resolver based on dynamic CMOS logic, some of which are modular and others are not. This article presents a novel gate-level modular design of priority resolvers that can accommodate any number of inputs and outputs. Based on our modular design architecture, small-size priority resolvers can be conveniently combined to form medium- or large-size priority resolvers along with extra logic. The proposed modular design approach helps to reduce the coding complexity compared to the conventional direct design approach and facilitates scalability. We discuss the gate-level implementation of 4-, 8-, 16-, 32-, 64-, and 128-bit priority resolvers based on the direct and modular approaches and provide a performance comparison between these based on the design metrics. According to the modular approach, different sizes of priority resolver modules were used to implement larger-size priority resolvers. For example, a 4-bit priority resolver module was used to implement 8-, 16-, 32-, 64-, and 128-bit priority resolvers in a modular fashion. We used a 28 nm CMOS standard digital cell library and Synopsys EDA tools to synthesize the priority resolvers. The estimated design metrics show that the modular approach tends to facilitate increasing reductions in delay and power-delay product (PDP) compared to the direct approach, especially as the size of the priority resolver increases. For example, a 32-bit modular priority resolver utilizing 16-bit priority resolver modules had a 39.4% reduced delay and a 23.1% reduced PDP compared to a directly implemented 32-bit priority resolver, and a 128-bit modular priority resolver utilizing 16-bit priority resolver modules had a 71.8% reduced delay and a 61.4% reduced PDP compared to a directly implemented 128-bit priority resolver.
A Review and Design Principle of Fixed-Bottom Foundation Scour Protection Schemes for Offshore Wind Energy
Authors: Gao Dongyue , Pan Xinying , Liang Bingchen , Yang Bo , Wu Guoxiang , Wang Zhenlu
Published: April 2024

Foundation scour is the erosion of sediments around pile foundations by wave and current in offshore wind energy. This phenomenon destabilizes foundations and poses a threat to pile safety. Therefore, scour protection becomes a crucial challenge in offshore wind projects. This paper reviews and synthesizes recent publications and patented technologies related to scour protection. Considering the primary engineering concerns, the paper proposes design principles for effective scour protection schemes to standardize evaluation criteria. These principles prioritize efficacy, independence, and cost-efficiency, enabling the analysis of scour protection scheme applicability. In addition, this paper summarizes and describes common protection schemes in the literature. The effectiveness of their protection is analyzed and summarized, and their economic and performance independence is evaluated. This paper categorizes flow-altering scour protection schemes found in the literature. Based on a comprehensive understanding of the mechanisms and engineering requirements of scour protection, the paper proposes a focus on determining the erosion reduction rate curve (Ep−U/Uc curve) as a key criterion for evaluating the effectiveness of protection schemes under varying flow velocities and the erosion reduction rate of scour protection schemes under extreme conditions. The study highlights the necessity of establishing a comprehensive design evaluation methodology, which is crucial for addressing the significant challenges related to scour encountered in offshore wind power projects.
Enhancement of Maritime Sector Decarbonization through the Integration of Fishing Vessels into IMO Energy Efficiency Measures
Authors: Díaz-Secades Luis Alfonso
Published: April 2024

The escalating impact of anthropogenic activities on global climate patterns necessitates urgent measures to reduce emissions, with the maritime industry playing a pivotal role. This article aims to examine the adoption of International Maritime Organization energy efficiency measures for the often-overlooked fishing vessels and their contribution to the overall maritime decarbonization efforts. The article analyzes the attained technical efficiency indices of a case study large-scale fishing vessel and compares them with those of two cargo ships where IMO measures already apply. To support the proposal, a comprehensive analysis of the energy efficiency indices of eight large purse seine fishing vessels is also presented. The results show that large-scale fishing vessels of 400 GT and above could be subject to the IMO energy efficiency measures. The operational challenges, unique to the fishing sector, suggest that sector-specific considerations may be required to integrate the fishing fleet into the already existing IMO energy efficiency guidelines. Looking ahead, this article explores the benefits of aligning Regulation (EU) 2023/957 and IMO guidelines, as well as applying the IMO Carbon Intensity Indicator (CII) in assessing the operational environmental impact of fishing operations, emphasizing the importance of including these vessels in the current regulatory frameworks to promote decarbonization.
Numerical and Experimental Study of Static and Dynamic Characteristics of Marine Shear-Compression Isolators
Authors: Zhang Ben , Zhao Yinglong , You Jingyue
Published: April 2024

Due to their ability to buffer and attenuate vibrations, as well as their low cost, rubber-based isolators are widely used in military and civilian vessels. Since these isolators are part of a ship’s structure, the accurate prediction of their static and dynamic performance is essential for overall structural design. In this paper, two kinds of marine shear-compression rubber isolators of different models in the same series are taken as the research objects, and the static and dynamic constitutive models of the rubber materials are obtained through material tests, which are used as inputs to accurately predict the static and dynamic characteristics of the isolators in the three translational directions through numerical calculations. The effects of size and preload force on the dynamic characteristics of the vibration isolators were analyzed as were the reasons for the peaks in the impedance curves. The results show that the preload force increases the amplitudes of the peak transfer impedance in the X direction and decreases it in the Z direction. On the other hand, as the size of the vibration isolator increases, the peak frequency of the transfer impedance in the X direction increases, while in the Y and Z directions, the first-order peak frequency decreases and the second-order peak frequency increases. The peaks of the transfer impedance curves appear due to the resonance of the embedded metal blocks, and the order of appearance of the resonance modes is fixed.
First Results of a Campaign of the Measurement of Polycyclic Aromatic Hydrocarbons in the Sediments of the Hooghly River, West Bengal, India
Authors: Arienzo Michele , Toscanesi Maria , Ferrara Luciano , Donadio Carlo , Mondal Priyanka , Ponniah Jonathan Muthuswamy , Napolitano Gaetana , Kumar Sarkar Santosh , Trifuoggi Marco
Published: April 2024

This study presents the first data on a 2018–2021 campaign to monitor polycyclic aromatic hydrocarbon levels, PAHs, in the final stretch of the Hooghly River in West Bengal, India. The range of sedimentary PAHs was 0–47,366 ng/g, higher than the ranges given by the literature for comparable study areas. The assay reveals an outstanding level of PAHs contamination in the fine sediments of the Hooghly River and Sundarban wetland, where the dominance of 4–6 ring PAHs was 83% of the total. The diagnostic ratios based on molecular ratios of PAHs show that the pollution comes mainly from the combustion of petroleum. The ratio of anthracene relative to anthracene plus phenanthrene, ANT/(ANT + PHE), was >0.30, which is higher than the reference discriminant ratio of >0.10, suggesting that PAHs were from the combustion source. In the meantime, fluoranthene over the sum of fluoranthene plus pyrene, FLT/(FLT + PYR), was >0.5 and indicated coal combustion, in agreement with the literature. The mean level of carcinogenic hydrocarbons was at 18% of the total measured PAH, with a peak of 91%, revealing significant potential risk for humans and ecosystems. The toxicity equivalence factors, TEF, of the individual PAHs and the total BaP equivalent toxicity, TEQ, were adopted as a comparison reference of sediment quality. At most sites, toxic effect ranges were classified as high and very high. The results of this research call for public authorities to remedy a situation of severe ecological risk.
The Combination of Enzymes and Conidia of Entomopathogenic Fungi against Aphis gossypii Nymphs and Spodoptera frugiperda Larvae
Authors: Ferreira Juliana M. , Fernandes Éverton K. K. , Kim Jae Su , Soares Filippe Elias F.
Published: April 2024

The slow action of fungi is one of the biggest challenges in using entomopathogenic fungi. A promising alternative to reduce the time of action is to combine conidia with extracellular enzymes. This study aimed to characterize the production of Pr1 subtilisin protease and lipases by Beauveria bassiana and Metarhizium anisopliae in different culture media and to evaluate the efficiency of the enzymatic treatment against Aphis gossypii and Spodoptera frugiperda. The isolates were cultivated in five different liquid cultures, and, after 7 days, the culture was filtered and centrifuged, and the activity of the Pr1 and lipases was measured. The fungi cultured in a Luria–Bertani broth medium had the highest activity of proteases and lipases. The mortality of A. gossypii nymphs treated with conidia 7 days after the treatment was 39% (JEF-410), 76.5% (JEF-492), 74.8% (ERL-836), and 70.9% (JEF-214). The B. bassiana JEF-410 supernatant combined with conidia increased the fungal virulence at day 5 and day 6 after treatment. When S. frugiperda larvae were treated with B. bassiana JEF-492 conidia combined with its supernatant, the time of infection was shorter compared to the larvae treated with conidia only. Once the supernatant was incubated at 37 °C, the relative activity decreased from 100% to 80% after 2 h and to 45% after 24 h. The results suggest that the supernatant of entomopathogenic fungi may be formulated and used as a biopesticide in an efficient strategy for the biological control of pests.
Impacts of the Transition to the Expected Loss Model on the Portuguese Banking Sector
Authors: Resende Miguel , Carvalho Carla , Carmo Cecília
Published: April 2024

This study addresses the implementation of the International Financial Reporting Standard 9 (IFRS 9) in the European Union as of 1 January 2018, replacing the International Accounting Standard 39 (IAS 39) to introduce a new model for recognizing Loan Loss Provisions (LLP), based on Expected Credit Loss (ECL). This model responds to criticisms of the former Incurred Credit Loss (ICL) system for its inability to reflect credit losses in a timely manner, potentially exacerbating the effects of financial crises. This study focuses on the effects of adopting the ECL model on the level of Loan Loss Allowances (LLA) in loans, own equity, and the Common Equity Tier 1 (CET1) ratio across 13 Portuguese commercial banks. A mean comparison test is used to evaluate scenarios before and after the application of the ECL model, highlighting the importance of regulator actions and the adequacy of loss recognition policies, including the effects of European Union. The results obtained demonstrate significant negative impacts on the net values of loans, own equity, and the CET1 ratio upon adopting the IFRS 9 ECL model due to the widespread increase in LLAs.
The Role of Artificial Neural Networks (ANNs) in Supporting Strategic Management Decisions
Authors: Justino Maria do Rosário Texeira Fernandes , Texeira-Quirós Joaquín , Gonçalves António José , Antunes Marina Godinho , Mucharreira Pedro Ribeiro
Published: April 2024

Nowadays, the dynamism caused by constant changes to strategic decisions in markets poses an additional difficulty in an organization’s management. The strategic decisions made by managers can easily become obsolete. One of the major difficulties in managing a commercial organization is predicting, with some precision, the impact some strategic decisions have on the financial results. Business intelligence (BI) is widely used to help managers make strategic decisions. However, the methods used to achieve the conclusions are kept secret by BI company-based services. Modeling the environment may help predict the impact of an action in a real environment. A good model should provide the most accurate result of an applied action in a given environment. Artificial neural networks (ANNs) are proven to be excellent in modeling environments with very high data noise. The same strategic action can have different results when applied to different organizations. A tool that allows the evaluation of an applied strategic action in an environment will be of great importance in the field of management. Modeling the environment will save time and money for the organization, allowing the performance of the strategic plan to be improved. If one evaluates the state of the environment after a certain strategic action is applied, it can be possible to mitigate its risk of failure. As we will verify, it is possible to use ANNs to model strategic environments, allowing precision in the prediction of sales and operating results using particular strategies.
Nature-Based Solutions in Spatial Planning: How to Adapt Land Use to Natural Heterogeneity in Agroforest Landscapes in Russia
Authors: Khoroshev Alexander V. , Emelyanova Lyudmila G.
Published: April 2024

We propose a land use planning protocol which integrates criteria for both the intrinsic properties of a unit and its significance in a broad spatial context. The purpose was to develop a methodology, represented as a questionnaire, that allows thorough consideration of the static and dynamic attributes of a landscape for making land use decisions. The methodology involves: (1) identification of landscape patterns, (2) revealing mechanisms of radial and lateral relationships, (3) considering changes of landscape patterns, (4) revealing functioning mechanisms that cause directed changes, and (5) socio-economic regulations. The protocol integrates knowledge of processes within biophysical units, catenas, catchments, and matrix elements. We proposed a plan for the taiga landscapes in northern European Russia. The highest ecological value was assigned to the units that control matter transportation over vast areas, and a lower value to the units that protect important habitats or intercept pollutants on their pathway towards rivers and floodplains. Outside the ecological network, we recommended reducing arable lands on eroded slopes (288 ha), increasing buffer zones at the footslopes (39 ha), and cultivating, instead, 331 ha of fallows with nutrient-rich soils.