bluuebunny/crossref_metadata_2025 huggingface dataset:
Phycobiliprotein-mediated synthesis of biogenic silver nanoparticles, characterization, in vitro and in vivo assessment of anticancer activities
Authors: El-Naggar Noura El-Ahmady , Hussein Mervat H. , El-Sawah Asmaa Atallah
Published: June 2018

Phycoerythrin is the main phycobiliprotein that responsible for harvesting light for photosynthesis in cyanobacteria. In this research, phycoerythrin extracted from the cyanobacterium Nostoc carneum has been used to reduce silver nitrate for silver nanoparticles (AgNPs) biosynthesis. UV–visible spectrophotometry for measuring surface plasmon resonance showed a single absorption peak at 430 nm, which confirmed the presence of AgNPs. The face-centered central composite design was chosen to evaluate the interaction effects between four process variables and also to determine their optimal levels which influence the AgNPs biosynthesis using phycoerythrin. The maximum silver nanoparticles biosynthesis (1733.260 ± 21 µg/mL) was achieved in the central runs under the conditions of initial pH 10, incubation period of the 24 h, phycoerythrin concentration of the 0.8 mg/mL and 20 mM of AgNO3. The biosynthesized AgNPs were characterized using TEM which revealed the formation of spherical shape nanoparticles with size ranged between 7.1‒26.68 nm. EDX analysis confirmed silver as the major constituent element. FTIR spectrum indicates the presence of proteinaceous capping agent that prevents silver nanoparticles agglomeration. The IC50 of cell inhibition by AgNPs was observed at 13.07 ± 1.1 µg/mL. Treatment of mice bearing Ehrlich ascites carcinoma with 5 mg AgNPs/kg of mice body weight significantly decreased tumor volume, tumor cells count, white blood cells count and body weight. It was concluded that the phycoerythrin protein has the ability to synthesize AgNPs, which have antibacterial, antihemolytic, in vitro and in vivo cytotoxic activities.
The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in β-cells
Authors: Tozzi Marco , Larsen Anna T. , Lange Sofie C. , Giannuzzo Andrea , Andersen Martin N. , Novak Ivana
Published: June 2018

Extracellular ATP is an important short-range signaling molecule that promotes various physiological responses virtually in all cell types, including pancreatic β-cells. It is well documented that pancreatic β-cells release ATP through exocytosis of insulin granules upon glucose stimulation. We hypothesized that glucose might stimulate ATP release through other non-vesicular mechanisms. Several purinergic receptors are found in β-cells and there is increasing evidence that purinergic signaling regulates β-cell functions and survival. One of the receptors that may be relevant is the P2X7 receptor, but its detailed role in β-cell physiology is unclear. In this study we investigated roles of the P2X7 receptor and pannexin-1 in ATP release, intracellular ATP, Ca2+signals, insulin release and cell proliferation/survival in β-cells. Results show that glucose induces rapid release of ATP and significant fraction of release involves the P2X7 receptor and pannexin-1, both expressed in INS-1E cells, rat and mouse β-cells. Furthermore, we provide pharmacological evidence that extracellular ATP, via P2X7 receptor, stimulates Ca2+transients and cell proliferation in INS-1E cells and insulin secretion in INS-1E cells and rat islets. These data indicate that the P2X7 receptor and pannexin-1 have important functions in β-cell physiology, and should be considered in understanding and treatment of diabetes.
Int6/eIF3e Silencing Promotes Placenta Angiogenesis in a Rat Model of Pre-eclampsia
Authors: Li Qin , Yao Baolin , Endler Alexander , Chen Li , Shibasaki Futoshi , Cheng Haidong
Published: June 2018

We investigated whether stable eukaryotic translation initiation factor 3e/inter 6 (eIF-3e/Int6) RNA-silencing (siRNA-Int6) can ameliorate pre-eclampsia (PE) by promoting angiogenesis in an N-nitro-L-arginine methyl ester (L-NAME)-induced rat pre-eclampsia (PE) model. Twenty-four pregnant female Sprague–Dawley rats were allocated into 4 groups, including controls (Con) without any treatment, and 18 from gestational day (GD) 7 to GD17 L-NAME-treated rats, which were divided into stable siRNA-Int6 transfected (siRNA-Int6), negative vector control siRNA (NC-siRNA) and PE control (PE-Con) groups. All adenovirus siRNA transfections were performed on GD7 via intravenous tail injection. On GD0, GD11 and GD17, blood pressure, and on GD6 and GD17, protein estimations in 24 h urine samples were conducted. All animals were sacrificed on GD18. In the PE-Con group, placental Int6 was expressed to a significantly greater level than in the Con group, which was reversed by the application of siRNA-Int6. Blood pressure and proteinuria were significantly lower in the siRNA-Int6 group than in the PRE-Con group. As shown by CD31 and IB4 expression, placental micro-vascular density (MVD) was significantly higher in the siRNA-Int6 group than in the PE-Con and NC-siRNA groups, which has accompanied by enhanced trophoblast invasion. Int6 silencing alleviated the maternal clinical manifestations of pre-eclampsia and promoted placental angiogenesis in pregnant L-NAME-treated rats.
Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences
Authors: Bayles R. G. , Olivas A. , Denfeld Q. , Woodward W. R. , Fei S. S. , Gao L. , Habecker B. A.
Published: June 2018

The stellate ganglia are the predominant source of sympathetic innervation to the heart. Remodeling of the nerves projecting to the heart has been observed in several cardiovascular diseases, however studies of adult stellate ganglia are limited. A profile of the baseline transcriptomic and neurochemical characteristics of the stellate ganglia in adult C57Bl6j mice, a common model for the study of cardiovascular diseases, may aid future investigations. We have generated a dataset of baseline measurements of mouse stellate ganglia using RNAseq, HPLC and mass spectrometry. Expression differences between male and female mice were identified. These differences included physiologically important genes for growth factors, receptors and ion channels. While the neurochemical profiles of male and female stellate ganglia were not different, minor differences in neurotransmitter content were identified in heart tissue.
Comparative transcriptome analysis of dikaryotic mycelia and mature fruiting bodies in the edible mushroom Lentinula edodes
Authors: Song Ha-Yeon , Kim Dae-Hyuk , Kim Jung-Mi
Published: June 2018

Lentinula edodes is a popular cultivated edible mushroom with high nutritional and medicinal value. To understand the regulation of gene expression in the dikaryotic mycelium and mature fruiting body in the commercially important Korean L. edodes strain, we first performed comparative transcriptomic analysis, using Illumina HiSeq platform. De novo assembly of these sequences revealed 11,675 representative transcripts in two different stages of L. edodes. A total of 9,092 unigenes were annotated and subjected to Gene Ontology, EuKaryotic Orthologous Groups, and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Gene expression analysis revealed that 2,080 genes were differentially expressed, with 1,503 and 577 upregulated in the mycelium and a mature fruiting body, respectively. Analysis of 18 KEGG categories indicated that fruiting body-specific transcripts were significantly enriched in ‘replication and repair’ and ‘transcription’ pathways, which are important for premeiotic replication, karyogamy, and meiosis during maturation. We also searched for fruiting body-specific proteins such as aspartic protease, gamma-glutamyl transpeptidase, and cyclohexanone monooxygenase, which are involved in fruiting body maturation and isolation of functional substances. These transcriptomes will be useful in elucidating the molecular mechanisms of mature fruiting body development and beneficial properties, and contribute to the characterization of novel genes in L. edodes.
Lymph node γδ and αβ CD8+ T cells share migratory properties
Authors: Ugur Milas , Kaminski Anne , Pabst Oliver
Published: June 2018

During immune responses, T cells differentiate into subsets with different functions and migratory properties. Here we characterize migratory behavior of endogenous αβ CD8+ and γδ T cells in lymph nodes by long-term tracking following in vivo photoconversion. We identified subsets of γδ T cells with distinct circulation kinetics that closely mirrored migratory subsets of αβ CD8+ T cells. Notably, αβ CD8+ and γδ T cells both comprised resident populations which stayed in lymph nodes for 4 weeks without circulation or proliferation. Furthermore, in contrast to the common conception, we observed that central memory αβ CD8+ T cells circulate with slower kinetics than naïve cells. Our results show that, similar to αβ T cells, γδ T cells can acquire distinct migratory properties during their development and differentiation and reveal unexpected intricacies of T cell migratory patterns.
Boron accumulation by Lemna minor L. under salt stress
Authors: Liu Chunguang , Gu Wancong , Dai Zheng , Li Jia , Jiang Hongru , Zhang Qian
Published: June 2018

Excess boron (B) is toxic to aquatic organisms and humans. Boron is often present in water with high salinity. To evaluate the potential of duckweed (Lemna minor L.) for removing B from water under salt stress, we cultured duckweed in water with 2 mg/L of B and sodium chloride (NaCl) concentrations ranging from 0 to 200 mM for 4 days. The results show that with increasing salinity, the capacity of L. minor to accumulate B initially decreased and then increased. L. minor used different mechanisms to accumulate boron at lower and higher levels of salt stress. The growth and chlorophyll synthesis of L. minor were significantly inhibited when the concentration of NaCl reached 100 mM. Our results suggest that L. minor is suitable for the accumulation of B when NaCl salinity is below 100 mM.
Author Correction: Multi-label Deep Learning for Gene Function Annotation in Cancer Pathways
Authors: Guan Renchu , Wang Xu , Yang Mary Qu , Zhang Yu , Zhou Fengfeng , Yang Chen , Liang Yanchun
Published: June 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Modified Newcastle Disease virus as an improved vaccine vector against Simian Immunodeficiency virus
Authors: Manoharan Vinoth K. , Khattar Sunil K. , LaBranche Celia C. , Montefiori David C. , Samal Siba K.
Published: June 2018

SIV infection in macaques is a relevant animal model for HIV pathogenesis and vaccine study in humans. To design a safe and effective vaccine against HIV, we evaluated the suitability of naturally-occurring avirulent Newcastle disease virus (NDV) strains and several modified versions of NDV as vectors for the expression and immunogenicity of SIV envelope protein gp160. All the NDV vectors expressed gp160 protein in infected cells. The gp160 expressed by these vectors formed oligomers and was incorporated into the NDV envelope. All the NDV vectors expressing gp160 were attenuated in chickens. Intranasal immunization of guinea pigs with modified NDV vectors such as rNDV-APMV-2CS/gp160 and rNDV-APMV-8CS/gp160 (NDV strain LaSota containing the cleavage site sequences of F protein of avian paramyxovirus (APMV) serotype 2 and 8, respectively), and rNDV-BC-F-HN/gp160 (NDV strain BC containing LaSota F cleavage site and LaSota F and HN genes) elicited improved SIV-specific humoral and mucosal immune responses compared to other NDV vectors. These modified vectors were also efficient in inducing neutralizing antibody responses to tier 1 A SIVmac251.6 and tier 1B SIVmac251/M766 strains. This study suggests that our novel modified NDV vectors are safe and immunogenic and can be used as vaccine vector to control HIV.
Influence of spent filter backwash water recycling on pesticide removal in a conventional drinking water treatment process
Authors: Li Wei , Liang Xinran , Duan Jinming , Beecham Simon , Mulcahy Dennis
Published: June 2018

The effects of recycling spent filter backwash water (SFBW) on the removal of 14 organic pesticides were examined in a simulated conventional drinking water treatment process.
Ir4+-Doped NiFe LDH to expedite hydrogen evolution kinetics as a Pt-like electrocatalyst for water splitting
Authors: Chen Qian-Qian , Hou Chun-Chao , Wang Chuan-Jun , Yang Xiao , Shi Rui , Chen Yong
Published: June 2018

Electrocatalytic water splitting with a low initial voltage of 1.41 V was achieved by using Ir-doped NiFe-LDH as a bifunctional catalyst.
GO–Cu7S4 catalyzed ortho-aminomethylation of phenol derivatives with N,N-dimethylbenzylamines: site-selective oxidative CDC
Authors: Gupta Sonu , Chandna Nisha , Dubey Pooja , Singh Ajai K. , Jain Nidhi
Published: June 2018

An efficient ortho-selective C–H aminomethylation of phenols and naphthols with N,N-dimethylbenzylamines using a GO–Cu7S4 nanocatalyst is reported.
Bis(alkylidynyl)arsines
Authors: Frogley Benjamin J. , Hill Anthony F.
Published: June 2018

The synthesis and characterization of the first examples of bimetallic bis(alkylidynyl)arsines are described. For the tungsten complexes, these may be prepared by a potentially generalizable route: successive treatment of [W(CBr)(CO)2(Tp*)] with nBuLi, ACl3 (A = P, As) and a nucleophilic source of R−via the inferred intermediacy of [ClA{CW(CO)2(Tp*)}2].
Multi-stage crystallization mechanism of electroactive phase polyvinylidene fluoride induced by thermal and supercritical carbon dioxide processing
Authors: Lee Ji Eun , Leung Siu Ning
Published: June 2018

The multi-stage crystallization mechanism of electroactive PVDF induced by thermal and supercritical CO2 processing was identified.
Screening heteroatom distributions in zeotype materials using an effective Hamiltonian approach: the case of aluminogermanate PKU-9
Authors: Arce-Molina Jorge , Grau-Crespo Ricardo , Lewis Dewi W. , Ruiz-Salvador A. Rabdel
Published: June 2018

We introduce a method to allow the screening of large configurational spaces of heteroatom distributions in zeotype materials.
Photocatalytic Sonogashira reaction over silicon carbide supported Pd–Cu alloy nanoparticles under visible light irradiation
Authors: Wang Bing , Wang Yingyong , Li Jiazhou , Guo Xiaoning , Bai Gailing , Tong Xili , Jin Guoqiang , Guo Xiangyun
Published: June 2018

PdCu alloy nanoparticles supported on SiC can efficiently catalyze the Sonogashira reaction by visible light irradiation under ligand-free and mild conditions. The superior catalytic activity of PdCu catalysts was caused by the synergistic effect of PdCu alloy nanoparticles.
Combinatorial alloying improves bismuth vanadate photoanodes via reduced monoclinic distortion
Authors: Newhouse P. F. , Guevarra D. , Umehara M. , Reyes-Lillo S. E. , Zhou L. , Boyd D. A. , Suram S. K. , Cooper J. K. , Haber J. A. , Neaton J. B. , Gregoire J. M.
Published: June 2018

Energy technologies are enabled by materials innovations, requiring efficient methods to search high dimensional parameter spaces, such as multi-element alloying for enhancing solar fuels photoanodes.
Dietary supplementalKluyveromyces marxianusalters the serum metabolite profile in broiler chickens
Authors: Wang Weiwei , Li Zhui , Gan Liping , Fan Hao , Guo Yuming
Published: June 2018

The current results elucidate the potential mechanisms associated with the probiotic properties ofK.marxianus.
Dual-ionic liquid system: an efficient catalyst for chemical fixation of CO2 to cyclic carbonates under mild conditions
Authors: Hu Jiayin , Ma Jun , Liu Huizhen , Qian Qingli , Xie Chao , Han Buxing
Published: June 2018

An easily prepared novel dual-ionic liquid system can catalyze the reactions of CO2 and epoxides to form cyclic carbonates under mild conditions (1 atmos CO2, T = 30–60 °C) with excellent yields in the absence of any solvents or additives.
A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function
Authors: Wang Xiaolin , Zhao Da , Phan Duc T. T. , Liu Jingquan , Chen Xiang , Yang Bin , Hughes Christopher C. W. , Zhang Weijia , Lee Abraham P.
Published: June 2018

We present a micropump enhanced with siphon-based autofill function to realize autonomous and continuous perfusion with steady flow over extended time.
Cross-linked networks that selectively and controllably disassemble on-demandviacascading bond cleavage
Authors: Daniels Grant C. , Camerino Eugene , Wynne James H. , Iezzi Erick B.
Published: June 2018

Silyl-containing polyurethane thermosets disassemble in multiple directionsviacascading bond cleavage when exposed to a fluoride ion stimulus.
Intracellular delivery of a molecularly imprinted peroxidase mimicking DNAzyme for selective oxidation
Authors: Zhang Zijie , Liu Juewen
Published: June 2018

Molecular imprinting of enzyme mimics allows delivery and selective catalysis and protection of the enzyme in cells.
Systems impact of zinc chelation by the epipolythiodioxopiperazine dithiol gliotoxin inAspergillus fumigatus: a new direction in natural product functionality
Authors: Saleh Aliabbas A. , Jones Gary W. , Tinley Frances C. , Delaney Stephen F. , Alabbadi Sahar H. , Fenlon Keith , Doyle Sean , Owens Rebecca A.
Published: June 2018

Dithiol gliotoxin (DTG) is a zinc chelator and an inability to dissipate DTG inAspergillus fumigatusis associated with multiple impacts which are linked to zinc chelation.
Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC
Authors: Li Meng , Zhang Bo , Yu Jia , Wang Jian , Guo Xingjie
Published: June 2018

Enantiomeric separation process of anticholinergic drugs and chiral recognition mechanisms on Chiralpak ID column.
Etoposide loaded layered double hydroxide nanoparticles reversing chemoresistance and eradicating human glioma stem cellsin vitroandin vivo
Authors: Wang Zhaojie , Liang Peng , He Xiaolie , Wu Bin , Liu Qiang , Xu Ziping , Wu Huijun , Liu Zhongmin , Qian Yechang , Wang Shilong , Zhu Rongrong
Published: June 2018

LDH-VP16 sensitizes GSCs and attenuates pluripotency gene expression, hence exhibits GSCs targeting capability, eliminates glioma at the prime state.
Silver nanoparticles deposited on graphene oxide for ultrasensitive surface-enhanced Raman scattering immunoassay of cancer biomarker
Authors: Yang Lin , Zhen Shu Jun , Li Yuan Fang , Huang Cheng Zhi
Published: June 2018

An ultrasensitive surface-enhanced Raman scattering (SERS) immunoassay of prostate specific antigen (PSA) is developed by introducing a common enzyme-induced dissolution reaction of AgNPs on the surface of graphene oxide (GO), which decreases the Raman signal of GO.
Bioelectronics communication: encoding yeast regulatory responses using nanostructured gallium nitride thin films
Authors: Snyder Patrick J. , LaJeunesse Dennis R. , Reddy Pramod , Kirste Ronny , Collazo Ramon , Ivanisevic Albena
Published: June 2018

Baker's yeast, S. cerevisiae, is a model organism that is used in synthetic biology.
Reduced graphene oxide-mediated synthesis of Mn3O4 nanomaterials for an asymmetric supercapacitor cell
Authors: Gao Mingyan , Wu Xiaofeng , Qiu Haifang , Zhang Qingfan , Huang Keke , Feng Shouhua , Yang Ying , Wang Tingting , Zhao Bo , Liu Zhelin
Published: June 2018

The existence presence of rGO can affect the morphology of an Mn3O4/rGO composite, and the asymmetric supercapacitor cell created with this composite exhibits good capacitive performance.
Dihydroartemisinin induces apoptosis and downregulates glucose metabolism in JF-305 pancreatic cancer cells
Authors: Zhu Wenhe , Zhang Wei , Xu Na , Li Yawei , Xu Junjie , Zhang Hong , Li Yan , Lv Shijie , Liu Wensen , Wang Huiyan
Published: June 2018

Cancer cell promotion of glycolysis provides a promising therapeutic target for cancer treatment.
Antibacterial coordination polymer hydrogels composed of silver(i)-PEGylated bisimidazolylbenzyl alcohol
Authors: Wu Fang , He Dengfeng , Chen Lei , Liu Fangqin , Huang Haolong , Dai Jiangshan , Zhang Shiyong , You Jingsong
Published: June 2018

Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water via coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (1a–c).
Effect of benzoic acid surface modified alumina nanoparticles on the mechanical properties and crystallization behavior of isotactic polypropylene nanocomposites
Authors: Jiang Xiaofeng , Zhang Wenxue , Zhao Shicheng , Zhou Shuai , Shi YaoQi , Xin Zhong
Published: June 2018

The CH–π interactions between polypropylene and functionalized alumina (BA-Al2O3) nanoparticles improve the mechanical performance and conformational ordering of nanocomposites.
(Ba,Sr)TiO3:RE perovskite phosphors (RE = Dy, Eu): nitrate pyrolysis synthesis, enhanced photoluminescence, and reversible emission against heating
Authors: Liu Wanlu , Liu Qian , Ni Jia , Zhou Zhenzhen , Liu Guanghui
Published: June 2018

Eu3+ and Dy3+ doped (Ba,Sr)TiO3 red and yellow phosphors were synthesized respectively. Substituting of Sr2+ for Ba2+ further enhance emission. BaTiO3:0.04Dy3+ possess an excellent thermal stability and the strongest emission recovery of 95% among the phosphors.
Essential role of enhanced surface electron–phonon interactions on the electrical transport of suspended polycrystalline gold nanofilms
Authors: Miao Tingting , Li Dawei , Shi Shaoyi , Ji Zhongli , Ma Weigang , Zhang Xing , Zhong Qing , Wang Xueshen
Published: June 2018

Considering the enhanced surface electron–phonon interaction, the electrical resistivity of suspended polycrystalline gold nanofilms with different length can be described very well in a temperature range from 2 K to 340 K.
Amplifying fluorescence signal contrast of aptamer-modified microspheres inspired by whispering-gallery mode lasing
Authors: Kim Sooyeon , Kuroda Ayaka , Fujitsuka Mamoru , Majima Tetsuro
Published: June 2018

We propose a new sensor design that maximizes fluorescence contrast, inspired by whispering-gallery mode lasing (WGM).
Molecule adsorption and corrosion mechanism of steel under protection of inhibitor in a simulated concrete solution with 3.5% NaCl
Authors: Zhang Zhifeng , Wang Fengjuan , Liu Yao , Wu Shengping , Li Weihua , Sun Wei , Guo Dong , Jiang Jinyang
Published: June 2018

Herein, the protective performance of a new triazole inhibitor for carbon steel was studied by electrochemical methods.
Enhanced thermoelectric properties of hydrothermally synthesized Bi0.88−xZnxSb0.12 nanoalloys below the semiconductor–semimetal transition temperature
Authors: Gharleghi Ahmad , Hung Roy-Hung , Yang Zong-Ren , Malekfar Rasoul , Liu Chia-Jyi
Published: June 2018

The peak zT is attained for hydrothermally synthesized Bi0.83Zn0.05Sb0.12 nanoalloy due to the significantly enhanced thermoelectric power factor and relatively low thermal conductivity.
Large-scale comparison of machine learning methods for drug target prediction on ChEMBL
Authors: Mayr Andreas , Klambauer Günter , Unterthiner Thomas , Steijaert Marvin , Wegner Jörg K. , Ceulemans Hugo , Clevert Djork-Arné , Hochreiter Sepp
Published: June 2018

The to date largest comparative study of nine state-of-the-art drug target prediction methods finds that deep learning outperforms all other competitors. The results are based on a benchmark of 1300 assays and half a million compounds.
Metal–semiconductor ternary hybrids for efficient visible-light photocatalytic hydrogen evolution
Authors: Wi Dae Han , Park Se Young , Lee Seunghoon , Sung Jiha , Hong Jong Wook , Han Sang Woo
Published: June 2018

A high-performance solar energy conversion platform was constructed by the intimate coupling of two different complementary semiconductors and morphology-controlled plasmonic metal nanocrystals in a controlled manner.
Red blood cell-like hollow carbon sphere anchored ultrathin Na2Ti3O7 nanosheets as long cycling and high rate-performance anodes for sodium-ion batteries
Authors: Chen Sheng , Pang Yuanchao , Liang Jin , Ding Shujiang
Published: June 2018

Unique ultrathin Na2Ti3O7 nanosheets on the surface of red blood cell-like hollow carbon sphere (RHCS) composites are fabricated as sodium-ion battery anodes.
An adaptive and stable bio-electrolyte for rechargeable Zn-ion batteries
Authors: Zhang Silan , Yu Nengsheng , Zeng Sha , Zhou Susheng , Chen Minghai , Di Jiangtao , Li Qingwen
Published: June 2018

An adaptive and stable gum bio-electrolyte was developed, which enabled Zn-ion batteries that have very competitive performances in terms of capacity, energy density, power density, rate capability and cyclability.
High-efficiency red organic light-emitting diodes based on a double-emissive layer with an external quantum efficiency over 30%
Authors: Wang Yanping , Wang Wenjie , Huang Zhaoji , Wang Huahang , Zhao Junting , Yu Jinhua , Ma Dongge
Published: June 2018

Red OLEDs (devices D1–D3) with a S-EML and a D-EML have been demonstrated to have different EQEs.
Efficient perovskite light-emitting diodes based on a solution-processed tin dioxide electron transport layer
Authors: Wang Heyong , Yu Hongling , Xu Weidong , Yuan Zhongcheng , Yan Zhibo , Wang Chuanfei , Liu Xianjie , Fahlman Mats , Liu Jun-Ming , Liu Xiao-Ke , Gao Feng
Published: June 2018

Solution-processed tin dioxide is employed as an electron transport layer in n–i–p-structured perovskite light-emitting diodes realizing an EQE of 7.9%.
Shikonin-mediated up-regulation of miR-34a and miR-202 inhibits retinoblastoma proliferation
Authors: Su Yan , Lu Shiyou , Li Jincun , Deng Liya
Published: June 2018

Retinoblastoma (RB) is an ocular tumor that occurs mainly in children.
Probing the specificity of CYP112 in bacterial gibberellin biosynthesis
Authors: Nagel Raimund , Peters Reuben J.
Published: June 2018

Biosynthesis of the gibberellin A (GA) plant hormones evolved independently in plant-associated fungi and bacteria. While the relevant enzymes have distinct evolutionary origins, the pathways proceed via highly similar reactions. One particularly complex transformation involves combined demethylation and γ-lactone ring formation, catalyzed in bacteria by the cytochrome P450 CYP112 in three individual steps, which involves large structural changes in the transition from substrate to product, with further divergence in the recently demonstrated use of two separate mechanistic routes. Here, the substrate specificity of the isozyme from Erwinia tracheiphila, EtCYP112, was probed via UV–Vis spectral binding studies and activity assays with alternate substrates from the GA biosynthetic pathway. EtCYP112 tightly binds its native substrate GA12 and reaction intermediates GA15 and GA24, as well as the methylated derivatives of GA12 and GA15. It, however, only poorly binds methylated GA24, its GA9 final product and the C-20 carboxylate side product GA25. These distinct affinities are consistent with the known reactivity of EtCYP112. However, while it binds to the immediately preceding pathway metabolite GA12-aldehyde and even earlier oxygenated ent-kaurene precursors, EtCYP112 only reacts with GA12-aldehyde and not the earlier ent-kaurene-derived metabolites. Even with GA12-aldehyde conversion is limited to the first two steps, and the full combined demethylation and γ-lactone ring-forming transformation is not catalyzed. Thus, CYP112 has evolved specificity at the catalytic rather than substrate-binding level to enable its role in GA biosynthesis.
Progress of heat resistant dielectric polymer nanocomposites with high dielectric constant
Authors: Zhu Ningning , Liang Guozheng , Yuan Li , Guan Qingbao , Gu Aijuan
Published: June 2018

Fast development of cutting‐edge areas including aviation and space, new energy, electrical and electronics industries asks for increasing requirements on heat resistant dielectric polymer nanocomposites with high dielectric constant (DK). This review focuses on recent research progress of thermally resistant polymer nanocomposites with high DK, which consists of four parts. In the first two parts, high DK nanocomposites based on thermally resistant thermoplastics and thermosetting resins are introduced, and then the effect of temperature on the dielectric properties of nanocomposites is discussed in the third part. In the last part, summary and future perspectives were provided.
Survey of advances and challenges in intelligent autonomy for distributed cyber‐physical systems
Authors: McKee David W. , Clement Stephen J. , Almutairi Jaber , Xu Jie
Published: June 2018

With the evolution of the Internet of things and smart cities, a new trend of the Internet of simulation has emerged to utilise the technologies of cloud, edge, fog computing, and high‐performance computing for design and analysis of complex cyber‐physical systems using simulation. These technologies although being applied to the domains of big data and deep learning are not adequate to cope with the scale and complexity of emerging connected, smart, and autonomous systems. This study explores the existing state‐of‐the‐art in automating, augmenting, and integrating systems across the domains of smart cities, autonomous vehicles, energy efficiency, smart manufacturing in Industry 4.0, and healthcare. This is expanded to look at existing computational infrastructure and how it can be used to support these applications. A detailed review is presented of advances in approaches providing and supporting intelligence as a service. Finally, some of the remaining challenges due to the explosion of data streams; issues of safety and security; and others related to big data, a model of reality, augmentation of systems, and computation are examined.
Cellules satellites et cellules souches musculaires
Authors: Chazaud Bénédicte
Published: June 2018

Le muscle strié squelettique adulte normal est capable de régénérer après une lésion, recouvrant ainsi complètement sa fonctionnalité. On sait depuis plusieurs décennies que cette capacité est due aux cellules satellites logeant le long des myofibres. Au début des années 2000, la myologie fondamentale a bénéficié du développement de nouvelles technologies et de l’émergence de l’étude des cellules souches adultes, qui ont identifié les cellules satellites comme les cellules souches adultes du muscle strié squelettique. Ces techniques ont également permis d’identifier plusieurs types de cellules souches non-satellites résidant dans le muscle et capables de former du muscle. Cet article présente une chronologie rapide des connaissances sur le sujet et aborde des questions actuelles quant à la biologie des cellules souches du muscle.
E-santé : gadget ou réel espoir ?
Authors: Marion Sylvie , Segovia-Kueny Sandrine
Published: June 2018

Les technologies numériques ont commencé d’étendre le champ des possibles pour les patients atteints d’une maladie neuromusculaire et leurs soignants. Du diagnostic à la prise en charge au long cours, la e-santé porte en elle le potentiel d’un puissant moteur d’amélioration du parcours de soins, mais aussi des pratiques et de l’organisation même du système de santé.
Participation de l’AFM-Téléthon (2012-2016) au Réseau Européen Help Lines d’Eurordis
Authors: Nga Brignol Tuy , Stalens Caroline , Houÿez François
Published: June 2018

Les informations sur les maladies rares sont souvent de compréhension complexe et d’accès difficile. Un accompagnement est souvent nécessaire. Des services d’assistance du réseau européen ENRDHL (European Network ofRare Disease Help Lines) travaillent ensemble à travers l’Europe pour répondre aux demandes de renseignements de tout public, incluant les patients et leurs proches, ainsi que les parties prenantes. Dans cet article, nous rapportons des données spécifiques aux maladies neuromusculaires sur la période 2012-2016, durant laquelle l’AFM-Téléthon a participé à l’enquête annuelle sur un mois donné de ce réseau coordonné par Eurordis.
A new experimental capability for the study of regolith surface physical properties to support science, space exploration, and in situ resource utilization (ISRU)
Authors: Dreyer Christopher B. , Abbud-Madrid Angel , Atkinson Jared , Lampe Alexander , Markley Tasha , Williams Hunter , McDonough Kara , Canney Travis , Haines Joseph
Published: June 2018

Many surfaces found on the Moon, asteroids, Mars, moons, and other planetary bodies are covered in a fine granular material known as regolith. Increased knowledge of the physical properties of extraterrestrial regolith surfaces will help advance the scientific knowledge of these bodies as well as the development of exploration (e.g., instrument and robotic) and in situ resource utilization (ISRU) systems. The Center for Space Resources at the Colorado School of Mines as part of the Institute for Modeling Plasma, Atmospheres, and Cosmic Dust of NASA’s Solar System Exploration Research Virtual Institute has developed a novel system, called the ISRU Experimental Probe (IEP) that can support studies of dry and icy regolith from −196 to 150 °C and pressure from laboratory ambient pressure to 10−7 Torr. The IEP system and proof-of-concept results are presented in this paper.
Chemical intermixing at oxide heterointerfaces with polar discontinuity
Authors: Liang Yan , Wang Yade , Liu Lixia , Guo Qinlin , Wang Weihua , Yang Hao , Guo Jiandong
Published: June 2018

The stability of the (4 × 4) reconstruction is studied on SrTiO3(111) and LaTiO3(111) surfaces by scanning tunneling microscopy. While the reconstruction may effectively compensate the surface polarity, the associated large lattice distortion on SrTiO3 with relatively strong polarity has to be relaxed by extra adsorbates. Alternatively, substituting Sr by La can reduce the polarity and stabilize the clean reconstructed surface. This provides the driving force for La segregating towards the surface during the heteroepitaxy of SrTiO3 on LaTiO3-covered SrTiO3(111), and thus, the interface sharpness will be deteriorated. To improve the quality of heterointerfaces where the surface polarity of substrates tends to be increased by the epitaxial films, the growth kinetics must be optimized to play the major role.
Electronic, magnetic and transport properties of silicene armchair nanoribbons substituted with monomer and dimer of Fe atom
Authors: DavoodianIdalik M. , Kordbacheh A. , Ghasemi N.
Published: June 2018

This study employed density functional theory calculations to investigate the structural, electronic and magnetic properties of an armchair silicene nanoribbon (ASiNR) substituted with a monomer and a dimer of Fe atom. As a result, the direct band gap of pristine ASiNR turns into a smaller indirect band gap by substituting an Fe atom in the proper position. The magnetic moment of doped Fe reduces and the structure keeps its nonmagnetic property. The substitution of the Fe-dimer can change the pristine ASiNR from a nonmagnetic semiconductor to a magnetic half-metal, which is favorable for spintronic devices. Two external electric fields were applied to the structure substituted with the Fe-dimer and electronic properties were studied in this situation. It was shown that the Fe-dimer substituted ASiNR is such a versatile material that a band gap can be tuned by using an external transverse electric field. Furthermore, the transport properties of these two structures were studied with non-equilibrium Greens function formalism. It is intriguing that single-spin negative differential resistance was observed in the Fe-dimer doped ASiNR.
Hybrid 2D/3D MoS2/GaN heterostructures for dual functional photoresponse
Authors: Huang Chun-Ying , Chang Cheng , Lu Guan-Zhang , Huang Wen-Chun , Huang Chun-Sheng , Chen Ming-Liang , Lin Tzu-Neng , Shen Ji-Lin , Lin Tai-Yuan
Published: June 2018

Recently, mixed-dimensional p-n heterojunctions have shown desirable optoelectronic functionalities. However, relatively little is known about the influence of interfacial traps on electron transport under external bias. Here, we explore the prominent dual optoelectronic characteristics of n-MoS2/p-GaN heterostructures, including photodetection and persistent photocurrent (PPC). The photoresponsivity was found to achieve as high as ∼105 A W−1 for 532 nm laser illumination under reverse bias. Additionally, the device exhibits the long-lasting PPC with a decay time constant (460 s) under forward bias. The results indicate that the hybrid heterojunctions not only function as high performance photodetectors under reverse bias but also have potential to use the unique property of PPC for other optoelectronic applications under forward bias alternatively.
The valence and Rydberg states of difluoromethane: A combined experimental vacuum ultraviolet spectrum absorption and theoretical study by ab initio configuration interaction and density functional computations
Authors: Palmer Michael H. , Vrønning Hoffmann Søren , Jones Nykola C. , Coreno Marcello , de Simone Monica , Grazioli Cesare
Published: June 2018

The vacuum ultraviolet (VUV) spectrum for CH2F2 from a new synchrotron study has been combined with earlier data and subjected to detailed scrutiny. The onset of absorption, band I and also band IV, is resolved into broad vibrational peaks, which contrast with the continuous absorption previously claimed. A new theoretical analysis, using a combination of time dependent density functional theory (TDDFT) calculations and complete active space self-consistent field, leads to a major new interpretation. Adiabatic excitation energies (AEEs) and vertical excitation energies, evaluated by these methods, are used to interpret the spectra in unprecedented detail using theoretical vibronic analysis. This includes both Franck-Condon (FC) and Herzberg-Teller (HT) effects on cold and hot bands. These results lead to the re-assignment of several known excited states and the identification of new ones. The lowest calculated AEE sequence for singlet states is 11B1 ∼ 11A2 < 21B1 < 11A1 < 21A1 < 11B2 < 31A1 < 31B1. These, together with calculated higher energy states, give a satisfactory account of the principal maxima observed in the VUV spectrum. Basis sets up to quadruple zeta valence with extensive polarization are used. The diffuse functions within this type of basis generate both valence and low-lying Rydberg excited states. The optimum position for the site of further diffuse functions in the calculations of Rydberg states is shown to lie on the H-atoms. The routine choice on the F-atoms is shown to be inadequate for both CHF3 and CH2F2. The lowest excitation energy region has mixed valence and Rydberg character. TDDFT calculations show that the unusual structure of the onset arises from the near degeneracy of 11B1 and 11A2 valence states, which mix in symmetric and antisymmetric combinations. The absence of fluorescence in the 10.8–11 eV region contrasts with strong absorption. This is interpreted by the 21B1 and 11A1 states where no fluorescence is calculated for these two states, which are only active in absorption. The nature of the two states, 11B1 and 21B1, is fundamentally different, but both are complex owing to the presence of FC and HT effects occurring in different ways. The two most intense bands, close to 12.5 and 15.5 eV, contain valence states as expected; the onset of the 15.5 eV band shows a set of vibrational peaks, but the vibration frequency does not correspond to any of the photoelectron spectral (PES) structure and is clearly valence in nature. The routine use of PES footprints to detect Rydberg states in VUV spectra is shown to be inadequate. The combined effects of FC and HT in the VUV spectral bands lead to additional vibrations when compared with the PES.
Large thickness dependence of the carrier mobility in a transparent oxide semiconductor, La-doped BaSnO3
Authors: Sanchela Anup V. , Wei Mian , Zensyo Haruki , Feng Bin , Lee Joonhyuk , Kim Gowoon , Jeen Hyoungjeen , Ikuhara Yuichi , Ohta Hiromichi
Published: June 2018

In this study, we report that the carrier mobility of 2%-La-doped BaSnO3 (LBSO) films on (001) SrTiO3 and (001) MgO substrates strongly depends on the thickness, whereas it is unrelated to the film/substrate lattice mismatch (+5.4% for SrTiO3 and −2.3% for MgO). The films exhibited large differences in lattice parameters, lateral grain sizes (∼85 nm for SrTiO3 and ∼20 nm for MgO), surface morphologies, threading dislocation densities, and misfit dislocation densities. However, the mobility dependences on the film thickness in both cases were almost the same, saturating at ∼100 cm2 V−1 s−1, while the charge carrier densities approached the nominal carrier concentration (=[2% La3+]). Our study clearly indicates that the carrier mobility of LBSO films strongly depends on the thickness. These results would be beneficial for understanding the carrier transport properties and fruitful to further enhance the mobility of LBSO films.
Perspective: Photonic flatbands
Authors: Leykam Daniel , Flach Sergej
Published: June 2018

Flatbands are receiving increasing theoretical and experimental attention in the field of photonics, in particular in the field of photonic lattices. Flatband photonic lattices consist of arrays of coupled waveguides or resonators where the peculiar lattice geometry results in at least one completely flat or dispersionless band in its photonic band structure. Although bearing a strong resemblance to structural slow light, this independent research direction is instead inspired by analogies with “frustrated” condensed matter systems. In this Perspective, we critically analyze the research carried out to date, discuss how this exotic physics may lead to novel photonic device applications, and chart promising future directions in theory and experiment.
Chemical potential of a test hard sphere of variable size in hard-sphere fluid mixtures
Authors: Heyes David M. , Santos Andrés
Published: June 2018

A detailed comparison between the Boublík–Mansoori–Carnahan–Starling–Leland (BMCSL) equation of state of hard-sphere mixtures is made with Molecular Dynamics (MD) simulations of the same compositions. The Labík and Smith simulation technique [S. Labík and W. R. Smith, Mol. Simul. 12, 23–31 (1994)] was used to implement the Widom particle insertion method to calculate the excess chemical potential, βμ0ex, of a test particle of variable diameter, σ0, immersed in a hard-sphere fluid mixture with different compositions and values of the packing fraction, η. Use is made of the fact that the only polynomial representation of βμ0ex which is consistent with the limits σ0 → 0 and σ0 → ∞ has to be of the cubic form, i.e., c0(η)+c¯1(η)σ0/M1+c¯2(η)(σ0/M1)2+c¯3(η)(σ0/M1)3, where M1 is the first moment of the distribution. The first two coefficients, c0(η) and c¯1(η), are known analytically, while c¯2(η) and c¯3(η) were obtained by fitting the MD data to this expression. This in turn provides a method to determine the excess free energy per particle, βaex, in terms of c¯2, c¯3, and the compressibility factor, Z. Very good agreement between the BMCSL formulas and the MD data is found for βμ0ex, Z, and βaex for binary mixtures and continuous particle size distributions with the top-hat analytic form. However, the BMCSL theory typically slightly underestimates the simulation values, especially for Z, differences which the Boublík–Carnahan–Starling–Kolafa formulas and an interpolation between two Percus–Yevick routes capture well in different ranges of the system parameter space.
Characteristics of ion-cyclotron surface waves in semi-bounded (r, q) distribution dusty plasmas
Authors: Lee Myoung-Jae , Ashikawa Naoko , Jung Young-Dae
Published: June 2018

The influence of magnetic field strength, ion mass, and the non-thermal character on the dispersion properties of ion-cyclotron surface wave is investigated in a semi-bounded (r, q) distribution dusty plasma. In the limit of short wave number, the dispersion relation is derived by adopting the specular reflection boundary condition and the effective screening distance in (r, q) distribution dusty plasma. It is found that the stronger magnetic field strength suppresses the wave speed, but the heavier ions will enhance the wave propagation. To investigate the wave propagation in the non-Maxwellian plasma, the typical values of r and q are chosen and the dispersion relation is plotted to obtain the general character of wave propagation. The result would reduce to the case of Maxwellian plasma for r→0 and q→∞.
Response of narrow cylindrical plasmas to dense charged particle beams
Authors: Gorn A. A. , Tuev P. V. , Petrenko A. V. , Sosedkin A. P. , Lotov K. V.
Published: June 2018

By combining the linear theory and numerical simulations, we study the response of a radially bounded axisymmetric plasma to relativistic charged particle beams in a wide range of plasma densities. We present analytical expressions for the magnetic field generated in the dense plasma, demonstrate vanishing of the wakefield potential beyond the trajectory of the outermost plasma electron, and follow the wakefield potential change as the plasma density decreases. At high plasma densities, wavefronts of electron density and radial electric field are distorted due to beam charge and current neutralization, while wavefronts of wakefield potential and longitudinal electric field are not. At plasma densities lower than or of the order of the beam density, multiple electron flows develop in and outside the plasma, resulting in a nonzero wakefield potential around the plasma column.
The affective construction in Yoron Ryukyuan
Authors: Seraku Tohru , Tohyama Nana
Published: June 2018

In Yoron Ryukyuan, passives are formed through the verbal suffix ‘-ari’. In this article, we observe that the suffix is used to form a construction distinguished from the standard passives in several respects: (i) attachment of ‘-ari’ to a wide range of predicates, (ii) ‘-ari’ obligatorily coexisting with the clause-linking suffix ‘-ti’, (iii) the case-marking pattern identical to that of active sentences, among other properties. Semantically, this construction expresses that the speaker is affected (typically, in an adversative fashion) by the situation denoted by the ‘-ari’-attached predicate. We call this linguistic unit "Affective Construction" (AC), revealing its unique syntactic and semantic properties. Furthermore, we suggest that the development of ‘-ari’ into ‘-ari-ti’ to constitute the AC may be viewed as an instance of grammaticalisation, with remarks on its generality in line with Unidirectionality and on the licensing conditions on the AC which seem to be uncommon cross-linguistically.
C. B. Macpherson: Philosopher or Radical Educator?
Authors: Lindsay Peter
Published: June 2018

Phillip Hansen’s Reconsidering C. B. Macpherson:From Possessive Individualism to Democratic Theory and Beyond has many virtues, principal among them the fact that it casts Macpherson’s thought in what to many will be the unfamiliar light of Continental critical theory. Doing so could broaden Macpherson’s audience to include those working within this tradition. What is less clear is whether casting Macpherson’s thought in this light will yield any new insights into his historical interpretations or his democratic theory. I argue that there may be reasons to doubt that it will.
Dramatherapy and Religion: (Un) Comfortable Bedfellows? in Honour of Dr Roger Grainger
Authors: Dokter Ditty , Carr Mandy
Published: June 2018

This article was written to honour the memory of Roger Grainger, particularly his contribution to the dialogue between (drama)therapy and religion. As authors from two different faith backgrounds, who work with clients of many and no faiths, we research the impact of working with religion in therapy, its potentially helping and hindering factors. In the context of PREVENT, a government strategy aiming to protect people from terrorism ( https://www.gov.uk/government/publications/prevent-strategy-2011 ), faith can be associated with radicalisation combined with a traditional distrust of therapy towards religion. This might lead us to shy away from this area. On the other hand The British Association of Dramatherapists' Intercultural good practice guidelines advocate working within a client's cultural, thus also religious background. The following argument discusses the core concepts we are working with, outlines Roger's contribution, contextualises them within current debates and raises the challenges we face. We hope the debate will be developed by fellow dramatherapists so that our fluency in interreligious practice will continue to improve.