bluuebunny/crossref_metadata_2025 huggingface dataset:
INSTRUMENTAL ASSESSMENT OF MYOCARDIAL FUNCTION BY DOPPLER TISSUE IMAGING IN CHILDREN WITH CONGENITAL HEART DEFECTS AFTER SURGICAL CORRECTION AND ITS CORRELATION WITH GALECTIN-3 AMOUNT AS BIOLOGICAL MARKER OF CARDIAC FIBROSIS
Authors: Dudnyk Veronika , Zborovska Olha , Vyzhga Yuilia , Khromykh Kateryna , Zvenigorodska Ganna , Popov Vladymyr , Bakhnivskyi Valentyn
Published: November 2020

Introduction: Speed myocardial indicators and estimation of galectin-3 presented for estimation of myocardial dysfunction in children with congenital heart defects (CHD).
The aim: Evaluate myocardial function while using tissue Doppler imaging (TDI) and galectin-3 in children with CHD after surgical correction.
Materials and methods: We examined 184 children. The study assessed both ventricle systolic and diastolic performance by TDI in combination with tricuspid annular plane
systolic excursion (TAPSE). Additionally, systolic (S') and diastolic (ratio E/E') TDI measurements were obtained at the lateral part of mitral annular, interventricular part, and lateral part of tricuspid valve (S`ma lateral, S` ma septal, S`ta lateral та E/E' malateral, E/E' maseptal, E/E' talateral). Galectin-3 amount in serum was detected by immune enzyme method by kit «HumanGalectin-3».
Results: Compared to results of the healthy children systolic TDI measurements in patients with CHD were significantly lower: S` ma lateral 7,81±0,10 сm/s vs 9,85±0,28 сm/s, S` ta lateral 9,70±0,12 сm/s vs 12,8±0,17 сm/s and TAPSE, 1,48±0,02 vs 2,14±0,03 сm/s (р<0,01). Ratio E/E' in patients with CHD were different from results of the healthy
children in all myocardial segments: E/Е` ma lateral 7,45±0,21 vs 6,17±0,12, E/Е` ma septal 9,17±0,22 vs 7,54±0,13, E/Е` ta lateral 6,42 ± 0,14 vs 4,64±0,12, (р<0,05).
Patients with CHD got galectin-3 content in serum 7,04±0,21 ng/ml vs 4,17±0,17 ng/ml (р<0,01) results of the healthy children.
Conclusions: Analyze of TDI measurements and galectin-3 content allows evaluate myocardial dysfunction in asymptomatic patients with CHD after surgical correction.
ASSESSMENT OF CHANGES OF SKIN MOISTURE IN PATIENTS SUBJECT TO GENERAL ANESTHESIA WITH NEUROLOGICAL DISEASES IN AN INTERVIEW
Authors: Piskorz Jolanta , Wójcik Gustaw , Bulikowski Włodzimierz , Kozak-Putowska Dorota
Published: November 2020

Introduction: General anaesthesia is carried out using anaesthetic agents that among others depress the circulatory system and CNS. Central and peripheral thermoregulation occurs, which is due to mild hypothermia as well as changes in skin moisture.
An important element of therapy in the perioperative period is adequate intravenous fluid therapy, which affects the final effects of treatment.
The aim: Evaluation of skin moisture as a result of changes in central and peripheral thermoregulation during general anaesthesia and evaluation of the hydration status of patients.
Material and methods: The study included 180 patients undergoing general anaesthesia for elective surgery, aged 20-85 years of age. Before general anaesthesia, patients were evaluated for ASA-related risk of anaesthesia (ASA 1 - healthy patients, ASA 2 and 3 - patients with neurological and circulatory disorders). Patients were divided into 2 groups, the study group (90 people) were patients who were given no intravenous fluids before the surgery and the control group (90 patients) were those receiving doses of 500 ml crystalline intravenously one hour before anaesthesia. The research was carried out at the Operational Block of the Provincial Hospital in Tarnobrzeg, from November 2013 to November 2014.
Skin moisture was measured using a CM 825 Corneometer: before general anaesthesia, after induction for anaesthesia, 15 min after surgical incision of the skin and after
awakening the patient.
Results: Both in the test and control groups, statistically significant differences were found in subsequent skin moisture measurements. Pairwise comparisons indicate statistically significant differences between each pair of measurements. In both groups of patients, there is a clear decrease in skin moisture after induction of anaesthesia compared to the measurement performed before general anaesthesia. The skin moisture values are reduced in subsequent measurements, however the difference is much lower.
Conclusions:
1 Measurement of skin moisture can be used as one of the parameters to assess perioperative stress and changes in body temperature during general anaesthesia, which indirectly determines the functioning of the hypothalamus.
2 By measuring the skin moisture it is possible to indirectly assess the hydration status of patients as well as the decrease of the metabolism during general anaesthesia.
3 The decrease in skin moisture during general anaesthesia is the effect of changes in central and peripheral thermoregulation.
GENERAL IMMUNOLOGICAL REACTIVITY OF PATIENT’S ORGANISM WITH CHRONIC HEPATITIS С
Authors: Balaniuk Iryna V. , Myronyk Elena V. , Randiuk Yuriy O. , Andruschak Аndriy V.
Published: November 2020

Introduction: Nowadays, the number of chronic carriers of hepatitis C virus (HCV) is considered to be from around 150 to 500 million by the most of infectionists and epidemiologists. Being one of the most dangerous diseases of the liver of viral etiology hepatitis C increases annually.
The aim: To determine the level of general immunological reactivity of patients with chronic hepatitis C.
Materials and methods: This study does not contradict the principles of the Helsinki Declaration (2013), the European Convention on Human Rights and Biomedicine.
A clinical and laboratory examination of 31 patients with chronic hepatitis C was conducted during 2014-2015 on the basis of the infectious department of Chernivtsi Regional Clinical
Results: The initial condition of clinical and laboratory examination of patients with chronic hepatitis C is normally considered to be a clinical examination of each patient and first of all hemograms where absolute and relative number of major populations of immunocompetent cells, platelets, erythrocytes and erythrocyte sedimentation rates (ESR) were determined.
Conclusions: General immunological reactivity in patients with chronic hepatitis C increased to 30,07% and the factors activation and mechanisms of nonspecific anti-infection protection decreased that create a condition for prolonged persistence of hepatitis C virus and the progression of a chronic infectious process in patients’ organism.
THE STUDY OF ORAL FLUID DYNAMIC PARAMETERS ON THE BACKGROUND OF PATHOLOGICAL AND PHYSIOLOGICAL DENTAL ABRASION
Authors: Kovalenko Viktor V. , Tkachenko Iryna M. , Nazarenko Zoryana Y. , Brailko Natalia M. , Romanova Julia G. , Sheshukova Olga V. , Vodoriz Yaroslav V.
Published: November 2020

Introduction: Violation of oral fluid mineralization processes, which is determined by the mineralization potential of saliva, is associated with changes in the physicochemical parameters of the oral fluid, particularly its viscosity.
The aim of our study was to study mineralization potential and types of microstallation of oral fluid as one of the factors of influence on the cariesogenic situation in the oral
cavity of patients with physiological or pathological tooth abrasion.
Materials and methods: During the examination of patients’ oral cavity, a comprehensive assessment of tooth hard tissues was performed in order to of study activity and prevalence of the processes occurring in them.
Results: Assessing the physico-chemical parameters of oral fluid in patients of the first experimental group, we obtained the following results: the viscosity of saliva in subgroups was 2,17 ± 0,87 for subgroup #1, 1,78 ± 0,57 for subgroup #2, and 2,15 ± 0,86 for #3 subgroups, which did not have a significant difference between the indices within the group. During the research, the number of independent structures of oral fluid in subgroups 1-3 was 1.67 ± 0.86, 1.67 ± 0.77 and 1.57 ± 0.85.
Conclusions: Thus, we have established that the mineralizing function of saliva changes when the cariesogenic situation in the oral cavity arises,. This leads to destabilization of the crystalline structure of the oral fluid and indicates the relationship between its structural and mineralizing properties.
SPECIFIC ASPECTS OF NORMATIVE LEGAL REGULATION OF ANATOMICAL MATERIALS’ TRANSPLANTATION IN UKRAINE AND FOREIGN COUNTRIES
Authors: Novytska Marina М.
Published: November 2020

Introduction: The article is devoted to the research of normative regulation of human organs and tissue transplantation in Ukraine and some foreign countries. A considerable part of problem aspects of transplantology in Ukraine is hidden due to the normative and legal base shortcomings, therefore there is a necessity of considering and borrowing foreign experience of legal regulation of this process, a legal regulation of the bases and conditions of providing consent to the removal of organs or refusal of the potential donor and legal consequences of it. The question as for the possibility of consolidating the “consent presumption” on the removal of organs and tissues at the legislative level remains current, but many experts express the idea of inadmissibility of such legislative actions because of the military operations on the territory of Ukraine and the imperfection of state control for the activities of institutions performing transplantation. At the same time, it is obvious that now the legislative regulation of the sphere of transplantology does not meet modern requirements, and creates certain gaps in the Ukrainian legislation.
The aim is to determine and concretize problematic issues of legal regulation of the transplantation sphere in Ukraine, to analyze the experience of the successful countries in this direction and to develop an integrated approach to the solution of certain problems.
Materials and methods: During the research, international normative acts, national legislation acts and scientific works of scholars were used. The article is based on the
dialectical, legal, historical, comparative, systematic methods of research.
Review: The analysis of the current situation of legal regulation of the sphere of transplantology in Ukraine has been carried out, the main problems and gaps, which must be eliminated as soon as possible for the real possibility of organ and tissue transplantation operations, are identified. The experience of the most progressive countries that are leaders in the number of transplantation operations is analyzed and their experience has been taken.
Conclusions: The solution of this problem is possible only after the transformation of the transplant coordination system, the introduction of the Unified State Information
System for transplantation, the training of specialized personnel, the improvement of the technical equipment of medical institutions, and the creation of an effective mechanism for regulating of the human anatomical materials’ transplantation.
MEDICAL TELECONSULTATION IN THE POLISH HEALTHCARE
SYSTEM
Authors: Paszkowska Małgorzata
Published: November 2020

Telemedicine is a relatively new form of medicine and healthcare combining elements of telecommunications, IT and medicine. Telemedicine is also increasingly important in
Poland. Currently, the law allows for the provision of medical health services using ICT systems. For physicians in practice the most important is the possibility of teleconsultation.
The public payer (National Health Fund) is financing in Poland the teleconsylum cardiology and geriatrics. The subject of the article is the presentation of the possibility of providing medical teleconsultations in the Polish healthcare system.
RELEVANT ISSUES OF THE CRIMINAL LIABILITY OF THE PRIVATE DOCTORS FOR CORRUPTION CRIMES
Authors: Bondarenko Olha S. , Pakhomov Volodymyr V. , Saulyak Sergey V. , Dumchikov Mykhailo O.
Published: November 2020

Introduction: Corruption, as a socio-economic problem, is characteristic of every society.
The aim: To study relevant issues of criminal liability of the private doctors for committing corruption crimes.
Materials and methods: In the article general scientific and special-scientific methods of cognition wer eused which provided an objective analysis of the research purpose.
Review: The article analyzes actual questions of relenant issues of criminal liability of the private doctors for committing corruption crimes. The authors propose to research
the criminal responsibility of this specific subject through the prism of the crime, as well as it’s elements. Thus, special attention is focused on the analysis of thees sence of the object of the crimes, the responsibility for which provided in. Art. 365-2 and 368-4 of the Criminal Code of Ukraine. Inaddition, the concept of “unlawful profit” is investigated, in the context of comparison with the “bribe”. Thees sence of the objective side of corruption crimes, the subject of which is a private doctor, is explained in detail. In particular, the concepts of “authority”, “offer”, “promise”, etc. Particul arattention is paid to analyzing the legal status of a private doctor as a person authorized to provide public services.
The authors focus on the analysis of the subjective side of thes corruption crimes being studied by a private physician. All penalties that can be applied to a private doctor for committing corrupt acts are systematized. At the very end, the issue of the totality of crimes is investigated.
Conclusions: Bringing a private doctor in the responsibility for committing a corrupt act is difficult in there gion, because the criminalization of corruptionactions of suchpersons took place relatively recently, therefore, pre-trial investigation bodies have not yet established a well-established system of tactical and methodological actions that would facilitate this process.
STOCHASTIC RESONANCE METHOD IN PHYSIOTHERAPY − A REVIEW OF THE LITERATURE
Authors: Bartczyk Mateusz , Suchanowski Andrzej , Woldańska-Okońska Marta
Published: November 2020

Non-linearity is an important feature of many human body structures that may result from deterministic properties of the body and noise. Noise is defined as accidental
or irregular fluctuations or disturbances that are not part of the signal. Stochastic resonance (SR), the term originally used in a very specific context, is now widely used to describe any phenomenon in which the presence of noise in a nonlinear system is better for the quality of the output signal than its absence. The conducted research for the needs of physiotherapy consists in assessing the impact of the platform generating forced mechanical vibrations with specific parameters in selected disease entities, sports disciplines, as well as prevention. The aim of the work is to discuss the stochastic resonance method and to analyze the results of the most important works discussing the use and effectiveness of therapeutic impact on the human body. The use of the stochastic resonance method enforces mechanical vibrations, which are characterized by the variability of rhythm, amplitude and direction of vibrations, which enforces postural adjustment regulated by the CNS and response to stimuli that disturb the body’s balance.
The analysis of the effectiveness of therapeutic impact in the field of body balance disorders, reeducation of locomotion in people with partial spinal cord injury, motor motility and changes in hormonal concentrations was carried out. Stochastic resonance therapy can reduce or eliminate dysfunction in many disease entities, however, further studies are needed to assess the effectiveness of the therapy.
PERSPECTIVE FOR EVALUATION OF MICRORNA IN PLASMA AND BILE FOR DIFFERENTIAL DIAGNOSIS OF OBSTRUCTIVE BILIARY TRACT DISEASE
Authors: Terletskiy Oleg M. , Kolomiytsev Vasyl I. , Lukavetskiy Oleksiy V. , Bufan Mariya M.
Published: November 2020

Introduction: Cholelithiasisis diagnosed in 10-25% of the adult population. The manifestation of cholelithiasis in the form of acute cholecystitis, cholangitis, jaundice etc. occurs with a probability of 2-3% or more per year depending on the risk factors. Most often, it manifests it self as acute calculous cholecystitis. Up to 20% of such patients have additional calculi in extrahepatic bile ducts requiring simultaneous surgical intervention. Currently, the algorithm for diagnosis of concomitant choledocholithiasis in acute cholecystitis is multilevel and it needs to be simplified and improved. Conventional non-invasive diagnostic techniques have low specificity and sensitivity. A new safe diagnostic test is needed for the diagnosis of choledocholithiasis in cholecystitis in order to improve the results of surgical treatment of patients.
The aim of the study - to determine the prospects for diagnosis of microRNA for differential diagnosis of obstructive diseases of the biliary tract on the basis of the literature data.
Materials and methods: The analysis of the selected international literature in the period of 1991-2018 concerning the studies of microRNA in cholestatic liver diseases was carried out. The search for literature was conducted using Google Scholar and PubMed search engines for the following keywords: microRNA, cholestasis, choledocholithiasis, acute cholecystitis, biliary obstruction in their various combinations.
Review: MicroRNA is a specific post-transcriptional regulator of gene expression in all organs and systems of the body. There are specific types of miRNAs for different tissues.
The most studied type of liver miRNA is miR-122. The studies showed better sensitivity and specificity of the detection of miR-122 both in the plasma and in the bile for the
diagnosis of pathological liver conditions compared with conventional liver tests (aminotransferase, alkaline phosphatase, gamma-glutamyltransferase). Regarding the cholestatic hepatocyte injury occurring in choledocholithiasis, the following types of miRNA were identified: 122, 21, 29, 125, 222, let-7, 98 etc. Their concentrations in plasma and bile can be used as a diagnostic test for the presence of concomitant benign cholestasis in acute cholecystitis. Moreover, these markers can be used for the differential diagnosis of cholestasis of different etiology.
Conclusions: Quantitative and qualitative characteristics of microRNA in bile and plasma can be used as an additional non-invasive method for diagnosis of cholestasis induced by choledocholithiasis in acute calculous cholecystitis. Further studyis needed to identify the most optimal algorithm for the administration of microRNA in clinical practice.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PERILAKU PEMBELIAN IMPULSIF KONSUMEN TOKOPEDIA MENGGUNAKAN ANALISIS DISKRIMINAN (Studi Konsumen Generasi Y dan Z Pada Masa Pandemi COVID-19)
Authors: Meria Christina Noviolita  , Puji Isyanto  , Asep Darojatul Romli
Published: November 2020

Abstrak

Tujuan penelitian ini untuk (1) mengetahui perbedaan antara dua kategori konsumen dalam melakukan pembelian impulsif di Tokopedia; (2) mencari faktor - faktor apa saja yang mempengaruhi dua kategori tersebut; (3) memperoleh model diskriminan dua faktor yang terbentuk; (4) mengetahui ketepatan hasil mengklasifikasi kasus dari model diskriminan tersebut. Manfaat penelitian ini diharapkan dapat menjadi dasar untuk penelitian berikutnya, serta menambah wawasan baru bagi program studi manajemen pemasaran. Penelitian dilakukan dengan menggunakan metode deskriptif asosiatif hubungan kausal dengan metode analisis diskriminan, serta mempelajari literatur yang berkaitan dengan topik penelitian, dan penyebaran angket sebagai data primer. Berdasarkan hasil analisis, maka diperoleh dua variabel yang layak dianalisis, yaitu jenis kelamin dan pendapatan konsumen. Model diskriminan dua faktor yang terbentuk adalah Zscore = -13,737 + 1,911 (jenis_kelamin) + 0,875 (pendapatan). Pengujian validasi diperoleh angka ketepatan yaitu 59%, maka fungsi diskriminan tersebut dapat digunakan untuk memprediksi kasus kategori konsumen Tokopedia.

Kata Kunci : Perilaku Konsumen, Faktor Pengaruh, Pembelian Impulsif.

 

 

Absract

The purpose of this study was to (1) find out the differences between the two categories of consumers making impulsive purchases on Tokopedia; (2) looking for the factors that affect the two categories; (3) obtain a two-factor discriminant model that is formed; (4) knowing the accuracy of the results of classifying cases from the discriminant model. The benefits of this research are expected to be the basis for further research, as well as add new insights to the marketing management study program. The research was conducted using the descriptive associative causal relationship with the discriminant analysis method, as well as studying the literature related to the research topic, and distributing questionnaires as primary data. Based on the results of the analysis, there are two variables that are worth analyzing, namely gender and consumer income. The two-factor discriminant model that is formed is Z score = -13,737 + 1,911 (gender) + 0.875 (income). In the validation test obtained the accuracy number is 59%, then the discriminant function can be used to predict cases of the Tokopedia consumer category.

Keywords : Consumer Behaviour, Influence Factor, Impulsive Buying
PENGARUH IKLAN MEDIA SOSIAL INSTAGRAM DAN CELEBRITY ENDORSER ( SELEBGRAM ) TERHADAP MINAT BELI (studi kasus pada toko online shop Keripik pisang coklat Krispbo.id ).
Authors: Heny Herawati
Published: November 2020

ABSTRAK

            Tujuan penelitian ini untuk mendapatkan bukti empiris mengenai “Pengaruh Iklan Media Sosial Instagram, dan celebrity endorser terhadap minat beli konsumen (studi kasus pada toko online shop Keripik pisang coklat Krispbo.id ). Pengujian hipotesis menggunakan analisis regresi berganda . Berdasarkan hasil analisis data dan pembahasan, secara parsial variabel Iklan Media Sosial Instagram (X1) berpengaruh positif teradap minat beli (Y). Variabel celebrity endorser (X2) secara parsial berpengaruh positif terhadap minat beli (Y). Secara simultan iklan media sosial instagram dan celebrity endorser berpengaruh signifikan terhadap minat beli. Koefisien determinasi sebesar 65,2% yang dijelaskan oleh iklan media sosial instagram dan celebrity endorser sedangkan sisanya 34,8%  yang tidak diteliti, seperti harga, kualitas, distribusi dan lain sebagainya.

 

Kata kunci : Iklan media sosial instagram, celebrity endorser, dan minat beli.

 

ABSTRACT

            The purpose of this study was to obtain empirical "Effect of Instagram Social Media Ads, and celebrity endorser on buying interest online shop consumers (case study on the online shop of Keripik pisang coklat Krispbo.id). Hypothesis testing uses multiple regression analysis. Based on the results of the data analysis and discussion, partially the Social Media Ads variable Instagram (X1) has a positive effect on buying interest (Y). The celebrity endorser (X2) variable partially has a positive effect on buying interest (Y). Simultaneously Instagram social media ads and celebrity endorsers have a significant effect on buying interest. The coefficient of determination of 65.2% is explained by Instagram social media advertisements and celebrity endorsers while the remaining 34.8% is not examined, such as price, quality, distribution etc.

 

Key words : Instagram Social Media , celebrity endorser and purchase intention.
CLINICALAND LABORATORY CНARACTERISTICS OF NEWBORNS FROM MOTHERS WITH ACUTE VIRAL HEPATITIS В AND FEATURES REНABILITATION
Authors: Sherengovskaya У. V. , Gorlova N. А. , Prokhorov D.V.
Published: November 2020

Eczema is a polyethyological disease that occurs as a result of the action of infectious and allergic, metabolic, neuroendocrine, vegetative and hereditary factors, clinically manifested by polymorphic rashes with a pronounced inflammatory reaction, accompanied by severe itching. Among all skin diseases of eczema takes the leading position, about 30-40 % of dermatological patients have this diagnosis. At the same time, every year there is a steady increase in the rate of eczema. Clinically effective is the use of complex treatment of eczema, which includes, in addition to standard pharmacological therapy, includes physiotherapeutic methods and spa factors, which together give a lasting positive therapeutic effect.
EXPERIENCE AND PROSPECTS FOR ТНЕ USE OF COLLECALCIPHEROL IN ТНЕ COMPLEX TREATMENT OF ESSENTIAL ARTERIAL HYPERTENSION IN CHILDREN
Authors: Dubovaya A. V. , Naumenko Уи.V.
Published: November 2020

The prevalence of arterial hypertension in children ranges from 1 to 25 %, depending on age and the selected criteria. Vitamin D can affect blood pressure (BP) through several mechanisms. The most important function of vitamin D is its role in the regulation of the renin-angiotensin-aldosterone system. The only metabolite of vitamin D that is used to determine its content in the human body is 25 (OH) D (calcidiol). The data on the effect of vitamin D on blood pressure in adolescents are contradictory, indicating a lack of knowledge of this issue. Objective: to evaluate the effectiveness of the use of an aqueous solution of vitamin D3 in the complex treatment of children with essential hypertension. Materials and methods. We examined 30 children (24 boys and 6 girls) aged 13 to 17 years with essential hypertension who had a deficiency of 25 (OH) D in blood serum, the treatment complex of which was supplemented with an aqueous solution of vitamin D3 at 1500 IU/day for 3 months. The control group consisted of 30 children (20 boys and 10 girls) with essential hypertension who received standard therapy. Results. In the main group, after 3 months of taking colecalciferol, a statistically significant normalization of vitamin D levels was documented in 15 (50.0 %) patients, an average of 33.26±1.2 ng/ml. Vitamin D deficiency persisted in 8 (26.6 %) children, vitamin D deficiency persisted in 7 (23.3 %) patients, which served as a basis for increasing the dose of colecalciferol to 2000 IU and continuing to take the drug for another 1 month with a reevaluation serum 25 (OH) D content. A study of the dynamics of blood pressure with the addition of complex treatment with colecalciferol showed that in 24 (80.0 %) children the level of blood pressure decreased, which was statistically significantly more often in comparison with the control group (53.3 %, p<0.05): systolic blood pressure decreased from 142.6±2.4 mm Hg up to 125±0.6 mm Hg (p<0.05), diastolic blood pressure – with 80.2±1.3 mm Hg up to 78.5±1.5 mm Hg. Normalization of blood pressure in the main group was detected after 31±4 days, while in the control group after 60±7 days (p<0.05). There were no adverse reactions during treatment. Conclusions: The positive effect of the drug is proved, which consists in restoring the normal content of 25 (OH) D in blood plasma and reducing systolic blood pressure.
INDICATORS OF ТНЕ FUNCTIONALACTIVITY OF ТНЕ THYMUS, STEM CELLS AND APOPTOSIS МARКERS IN PATIENTS WITH JUVENILE RHEUМATOID ARTHRITIS АТ ТНЕ SANATORIUM STAGE OF REНABILITATION
Authors: Soboleva Е. М. , Kaladze N N.
Published: November 2020

The aim of the study was to evaluate the effect of sanatorium treatment on the indicators of the functional activity of the thymus, stem cells and apoptosis markers in patients with juvenile rheumatoid arthritis. Material and methods. 48 patients with juvenile rheumatoid arthritis were examined. The effect of sanatorium rehabilitation on the functional activity of the thymus was evaluated by the changes in the release of its main hormone, α1-thymosin, as well as of markers of stem cells (CD34) and apoptosis (CD95). The control group consisted of 15 healthy peers. Results. In juvenile rheumatoid arthritis, the functional activity of the thymus decreases, which is manifested by significantly lower levels of secretion of its main hormone α1-thymosin, which can contribute to the disruption of the processes of T-lymphocyte selection and the appearance of autoreactive clones. There was also a significant increase in stem cell markers (CD34) and markers of the readiness of activated lymphocytes for apoptosis (CD95). This fact indicates the accumulation of poorly differentiated cells in the systemic bloodstream and impaired apoptosis. Sanatorium treatment leads to a significant increase in α1-thymosin and positive changes in CD34 and CD95 levels. Conclusion. The factors contributing to the development of an autoimmune process were identified in patients with juvenile rheumatoid arthritis. A decrease in thymus α1-thymosin, combined with an increased level of CD34 and CD95, can contribute to the impairment of negative selection of T-lymphocytes in the thymus, accumulation of autoreactive clones and poorly differentiated cells that have not undergone apoptosis in the systemic circulation. Sanatorium treatment has a normalizing effect on the parameters under study.
EFEITO DE QUATRO EXTRATOS DE PLANTAS SOBRE AS FASES IMATURAS DE MOSCA MINADORA (Liriomyza trifolii) EM TOMATEIRO
Authors: Rocha Luan Ítalo Rebouças , Pratissoli Dirceu , DAMASCENA ALIXELHE PACHECO , De Araujo Junior Luis Moreira , De Carvalho José Romário
Published: November 2020

A principal estratégia de controle de Liriomyza trifolli tem sido realizado com inseticidas sintéticos, os quais podem ocasionar diversos problemas relacionados a contaminação. O uso de inseticidas botânicos, como os extratos vegetais no manejo de moscas minadoras é uma alternativa que apresenta resultados satosfatórios. O objetivo do trabalho foi avaliar o potencial inseticida de extratos de pimenta, fumo, alho e óleo de mamona à L. trifolli em tomateiro. Os extratos foram testados nas concentrações de 1,2; 1,8 e 2,5 mL/100mL de água. Primeiramente, os extratos foram aplicados em 10 plantas de tomateiro (50 dias após a semeadura), anteriormente submetidas à infestação de L. trifolli durante 4 horas. Para aplicação dos extratos, foi utilizado um pulverizador automático pressurizado (pressão de 15 lb/pol²), liberando 6 mL de solução. As avaliações foram iniciadas um dia após a pulverização, contabilizando-se a presença de minas nas folhas, número de larvas vivas e mortas e viabilidade de pupas. Para avaliar o efeito dos extratos e das concentrações sobre a fase larval, plantas de tomateiro, com as mesmas características do experimento anterior, foram submetidas à infestação da praga, durante 4 horas. Após 72 horas foram pulverizados os extratos com as respectivas concentrações. Os dados de mortalidade larval, pupal e mortalidade total foram submetidos à análise de variância, regressão e as médias comparadas pelo teste de Tukey a 5% de probabilidade. Verificou-se que extratos vegetais de pimenta, alho, fumo e mamona testados são eficientes no manejo de L. trifolli em tomateiro, proporcionando mortalidade larval e pupal da praga.
Tecnologías de la Información y las Comunicaciones: Herramientas que apoyan el acceso al mercado laboral de personas con diversidad funcional visual
Authors: Ortiz-Clavijo Luis Felipe , Giraldo Gutiérrez Francisco Luis
Published: November 2020

This manuscript is derived from an investigative exercise that forms part of the theoretical sustenance in the development of a master thesis, with the objective of evaluating the implementation of a governmental project oriented to train in the use and appropriation of technological tools by the population with visual functional diversity in Colombia. In this article, show various theoretical positions based since the science, technology and society studies, accessibility and functional diversity. Finally, a synthesis is made from the STS studies and the disability models.
El diseño como componente significativo en los observatorios de políticas públicas en Colombia
Authors: López Ospina Sebastián
Published: November 2020

Este artículo aborda el concepto de diseño como un elemento interdisciplinario que busca reconocerse como un vehículo para crear conciencia sobre los procesos de socialización en los observatorios que tienen como objetivo generar un impacto en una comunidad específica. El diseño visto como conocimiento debe ser recordado desde su formalización como una herramienta disponible para las personas que, en su manifestación (reificación / función) pasan a un segundo plano para ser reconocidas como un acto cognitivo que conduce a instancias significativas. Por lo tanto, se planea la siguiente premisa: ¿Cómo contribuye el diseño a la construcción de conciencia en los procesos de socialización del observatorio en la política pública de control fiscal?
Creatividad, pensamiento y artivismo feminista en Chile ¡Ahora es cuando!
Authors: Freire Smith Marla
Published: November 2020

Las distintas acciones realizadas por colectivos y grupos feministas en Chile reconfiguran las formas de concebir el arte de acción y generan catarsis colectivas. “Acuerpar” el espacio público, renombrar las estaciones de Metro de Santiago y calles para visibilizar mujeres, evidencian la omisión histórica pero también, la violencia epistémica. A partir de las epistemologías feministas este artículo analiza cómo creatividad y feminismos, a través de la performatividad a cargo de distintos grupos y artistas (Yeguada Latinoamericana y LasTesis, entre otras) podrían desestabilizar estructuras de poder y deconstruir la(s) historia(s).
White Zombie as Captivity Narrative and the Death of Certainty
Authors: Anderson Mark C
Published: November 2020

Horror films such as White Zombie (1932) reveal viewers to themselves by narrating in the currency of audience anxiety. Such movies evoke fright because they recapitulate fear and trauma that audiences have already internalized or continue to experience, even if they are not aware of it. White Zombie’s particular tack conjures up an updated captivity narrative wherein a virginal white damsel is abducted by a savage other.

The shell of the captivity story is as old as America and relates closely to the Western and to the frontier myth, from which the Western emerged. What inexorably links the Western and all zombie films is the notion of containment. Whereas the Western sought to contain the American Other, all zombie films ask, instead, what happens if the other breaks through the proverbial gates. In other words, what if containment fails?
DETERMINAN MOTIVASI KERJA DAN IMPLIKASINYA TERHADAP KOMITMEN PEGAWAI PUSDIKLAT KEMENTERIAN AGAMA REPUBLIK INDONESIA
Authors: Sairin Sairin , Harras Hadyati
Published: November 2020

The state civil apparatus is a state servant in charge of serving the community. Therefore, they are required to work professionally and integrity. To achieve good performance requires an attitude of commitment, and this is influenced by many factors including leadership, organizational culture, and work motivation. This study aims to analyze these three factors, how they affect commitment. Research methods using quantitative and path analysis. The research site at Education and Training Center of Indonesian Religion Ministry. The unit of analysis sampled was 50 people (employees who volunteered to fill out the questionnaire). The results showed that organizational culture can significantly increase employee commitment if work motivation to be mediation
Plaučių vaskulito diagnostika ir gydymas
Authors: Barkauskienė Diana , Klimaitė Raimonda , Slabada Marius
Published: November 2020

Vaskulitas – kraujagyslės sienelės uždegimas, dažnai lydimas nekrozės, okliuzinių pokyčių, kurie sutrikdo kraujotaką pažeistos kraujagyslės baseine. Plaučių vaskulito klinikiniai sindromai yra įvairūs ir sudėtingi. Sindromai gali būti pirminiai arba jais pasireiškia kita, pagrindinė, liga. Plaučių vaskulitas neturi jokių laboratorinių patognominių požymių, diagnozė grindžiama his-tologiniais požymiais. Šios ligos sunkiai diagnozuojamos, nes dažniausiai remiamasi kitų ligų paneigimo ir atmetimo principu.
Plautinės hipertenzijos etiopatogenezė ir klasifikacija
Authors: Miliauskas Skaidrius , Žemaitis Marius
Published: November 2020

Straipsnyje apžvelgiama plautinės hipertenzijos etiopatogenezė bei pateikiama naujausia klasifikacija.
Gripo pamokos Lietuvoje ir gairės ateičiai
Authors: Bagdonas Alfredas , Valentij Oksana
Published: November 2020

Gripas yra viena iš labiausiai paplitusių ir grėsmingiausių ūminių viršutinių kvėpavimo takų infekcinių ligų. Lietuvos miestuose epidemijos metu sergamumas pasiekia 20–50 proc., o liga pavojinga tuo, jog nepavyksta išvengti grėsmingų komplikacijų ir mirties atvejų. Kadangi Lietuvoje skiepijasi kritiškai mažai gyventojų, išvengti skausmingų gripo padarinių artimiausioje ateityje nepavyks. Apie tai būtina plačiau informuoti visuomenę. Straipsnyje aptariama gripo pandemijas sąlygojantys veiksniai, 2009–2011 metų laikotarpio epidemiologinė gripo situacija Lietuvoje, gresiančios gripo komplikacijos, gydymo ir profilaktikos ypatumai, skiepų svarba apsisaugoti nuo gripo.
Alerginių kvėpavimo takų ligų gydymas poliežuvine alergenų specifine imunoterapija
Authors: Bajoriūnienė Ieva
Published: November 2020

Etiologiniai alerginių kvėpavimo takų ligų gydymo būdai – vengti alergenų ir alergenų specifinė imunoterapija. Poliežuvinė alergenų specifinė imunoterapija yra daugelyje šalių pripažintas metodas gydyti alerginiu rinokonjunktyvitu su astma ar be jos sergančius vaikus ir suaugusiuosius. Šis gydymo metodas saugus ir sukelia ilgalaikį efektą, todėl yra perspektyvus.
Imunologo rekomendacijos pasikartojus Herpes simplex viruso infekcijai
Authors: Staikūnienė Jūratė
Published: November 2020

Herpes simplex viruso (HSV) sukelta pūslelinė yra viena dažniausių užkrečiamųjų ligų, kuria serga 60–95 proc. suaugusiųjų. HSV infekcija persistuoja ir pasikartoja visą gyvenimą. Pirmojo tipo virusu HSV-1 užsikrečiama vaikystėje, dažniausiai jis sukelia burnos ir lūpų pūslelinę, rečiau keratitą, encefalitą, kurie dažnesni imunosupresinės būklės žmonėms. Antrojo tipo virusas HSV-2 sukelia lyties organų ligą, prasideda jauniems žmonėms pradėjus lytinius santykius ir dažnėja didėjant amžiui. Vis dažniau lyties organų pūslelinės priežastis yra HSV-1. Užsikrėtus HSV formuojasi humoralinis ir ląstelinis imuninis atsakas, tačiau virusas turi įvairių apsaugos mechanizmų, leidžiančių persistuoti nervų ląstelėse ir reaktyvuotis. Ilgalaikis virusą slopinantis gydymas nukleozidų analogais (acikloviru, valacikloviru ir kt.) ne tik apsaugo nuo mirtinų šios infekcijos komplikacijų, bet ir ženkliai sumažina kartojimosi dažnumą.
Ambulatoriškai vartojamo azitromicino vaidmuo gydant visuomenėje įgytą pneumoniją
Authors: Nutautienė Rūta
Published: November 2020

Visuomenėje įgyta pneumonija (VĮP) pasaulyje sergama gana dažnai, o jos sukėlėjas nustatomas rečiau nei 50 proc. atvejų, ambulatoriškai gydomiems pacientams dažniausiai net netiriamas. Remiantis tyrimų duomenimis ir rekomendacijomis, dažniausiai VĮP gydyti antibiotikų skiriama empiriškai, taigi jie turi veikti Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydia pneumoniae ir Legionella pneumophila. Makrolidai, ypač naujos kartos (azitromicinas), yra mažiau toksiški ir geresnes farmakokinetines savybes turintys alternatyvūs vaistai, vartotini, kai pacientas netoleruoja pirmos eilės vaisto. Klinikinių tyrimų rezultatai rodo, kad trijų dienų trukmės gydymas azitromicinu yra efektyvus ir saugus gydant viršutinių bei apatinių kvėpavimo takų infekcines ligas kasdienėje klinikinėje praktikoje.
Advancing Sustainability Education in Business Studies through Digital Service Learning
Authors: Perkiss Stephanie , Anastasiadis Stephanos , Bayerlein Leopold , Dean Bonnie , Jun Hannah , Acosta Pilar , Gonzalez-Perez Maria Alejandra , Wersun Alec , Gibbons Belinda
Published: November 2020

To support the development of a society that is attuned to the challenges presented by sustainable development, it is vital that higher education business students understand the value of sustainability, and act in a way that is consistent with these values. This paper explores a sustainability-focused experiential learning activity through investigating the utility of an emerging form of service learning in the digital space for developing global citizens. The paper presents an international case study of educators who employed digital service learning in various business education contexts. The research reports on the perceptions of higher education students in relation to their awareness, critical thinking and action for sustainability. The paper has practical contributions in identifying an opportunity for implementing sustainability curriculum into higher education for business.
Navigating the Web of Informal Institutions When Investing in a Strange Land: Chinese Multinational Enterprises in Australia
Authors: Zhang Mingqiong Mike , Lu Ying , Zhu Jiuhua Cherrie , Zhou Hui
Published: November 2020

Multinational enterprises (MNEs) need to understand and handle various informal institutions in host countries to survive and succeed. How MNEs effectively manage informal institutional characteristics of host countries is an important question for both practitioners and scholars. This paper addresses this important but neglected topic based on an in-depth longitudinal qualitative study. It identifies some key informal institutions in Australia, examines how such institutional distinctiveness shapes the behaviour of Chinese expatriates and MNEs and how they handle such informal institutional differences between China and Australia. Our findings challenge some taken-for-granted assumptions regarding informal institutions in the literature and demonstrate that informal institutions of host countries significantly shape the behaviour of expatriates and firm-level strategies of MNEs.
Seller Financing: Contracting Out of the Lemons and Moral Hazard Problems When They May Co-Exist
Authors: Tirtiroglu Dogan , Tirtiroglu Ercan
Published: November 2020

Quality problems that are known to the seller of an asset, but will become known to the buyer only after the purchase have the potential to frustrate voluntary exchanges. When the problem is subtle or confounded by the extent of buyer inputs, requiring risk-sharing by the contracting parties, both parties would benefit from a mechanism, such as seller financing, which not only credibly signals to the buyer the veracity of the seller’s representations about the asset (s)he is trying to sell, but also offers the seller sufficient protections against the potential that the buyer may engage in post-sale opportunistic behavior about the maintenance of the asset. We analyze one-time-only mortgage contracts in the National Association of Realtors' Home Financing Transaction database for 1984-1996, (data not collected outside this period), and find empirical support for seller financing as an asset quality signal and, separably, as a mechanism for providing credit when conventional credit sources are tight. We also point out the broad, but not well-acknowledged, reach of seller financing, including the sub-prime loan debacle, the earnout mergers or reverse annuity mortgages, which are inherently embedded with both asymmetric information about the quality of the relevant assets and moral hazard about the asset acquirer’s post-purchase maintenance.
Contributions of Crude Oil Exchange Traded Funds in Price Discovery Process
Authors: Shrestha Keshab , Philip Sheena , Peranginangin Yessy
Published: November 2020

This study empirically investigates the contributions of three crude oil-based exchange-traded funds (ETFs) in the price discovery process. Using daily data on the crude oil spot, near month crude oil futures, and three crude-oil-based ETFs, we analyze the price discovery contributions of the five-price series. We use two information share measures, namely the generalized information share (GIS) measure (Lien and Shrestha, 2014) and the permanent-temporary decomposition (PT/GG) measure (Gonzalo and Granger, 1995). We find that the futures market dominates the price discovery process. However, we also find that the crude-oil-based ETFs significantly contribute to the price discovery process. Thus, we find that additional ETFs play a significant role in price discovery. Therefore, they are not redundant in terms of their price discovery contributions.
Diversität im Mathematikunterricht der Grundschule. Theoretische Grundlegung und empirische Untersuchungen zu Gelingensbedingungen inklusiven Mathematiklernens
Authors: Dexel Timo
Published: November 2020

Die Entwicklung eines inklusiven Schulsystems gehört zu den zentralen Aufgaben des Bildungswesens im 21. Jahrhundert. Inklusion wird als pädagogisches Rahmenkonzept verstanden, dessen Ziel es ist, Bildungs- und Teilhabebarrieren für alle SchülerInnen abzubauen. Dies korrespondiert mit einem positiven Verständnis von SchülerInnenvielfalt im Sinne der Diversität. Obwohl in den letzten Jahren vielfältige Forschungsprojekte u. a. an­knüpfend an die Erkenntnisse der Integrationsforschung durchgeführt wurden, stellt die Erforschung eines inklusiven Mathematikunterrichts bislang ein Desiderat dar. Die Hauptintention dieses Buches besteht darin, unter dem Fokus der Entwicklung eines tragfähigen mathematikdidaktischen Konzeptes die Inklusions-/Ex­klu­sionsfor­schung zu analysieren und eine empirisch begründete Kennzeichnung der wesentlichen Gelingensbedingungen für die Gestaltung und Durchführung von inklusivem Mathematikunterricht darzulegen. Hierfür werden aktuelle Konzepte inklusiven Mathematikunterrichts auf Basis einer interdisziplinär angelegten Literaturrecherche analysiert. Mithilfe von leitfadengestützten Interviews mit LehrerInnen, WissenschaftlerInnen, Eltern und Kindern werden Gelingensbedingungen inklusiven Mathematiklernens erhoben, theoretisch diskutiert und reflektiert, um sie modellartig im Sinne von Grundorientierungen für den Mathematikunterricht der Primarstufe zusammenzufassen.
Analisis Suasana Toko, Potongan Harga Dan Penataan Produk Terhadap Pembelian Impulsif
Authors: Safitri Nadia , Hadi Prasetyo , Dwi Bernadin
Published: November 2020

This research is a quantitative study that aims to determine the effect of the atmosphere of the store, price discounts and product arrangement on impulsive purchases. The population in this study are consumers who have shopped at the Ramayana Department Store in the Jakarta area. Sample size was taken as many as 75 respondents, with non-probability sampling methods especially purposive sampling. Data collection in this study was carried out through questionnaires. The analysis technique used is the PLS (Partial Least Square) analysis method with SmartPLS software version 3.0. The results of this study indicate that (1) store atmosphere does not affect impulsive purchases with a path coefficient of 0.067. (2) the price discount significantly influences impulsive purchases with a path coefficient of 0.417. (3) product structuring significantly influences impulsive purchases with a path coefficient of 0.482.

 

Keywords: Store Atmosphere, Price Discount, Display Product, Impulse Buying