bluuebunny/crossref_metadata_2025 huggingface dataset:
ФОРМУВАННЯ ІНВЕСТИЦІЙНОГО РЕСУРСУ СТРУКТУРНОЇ МОДЕРНІЗАЦІЇ НАЦІОНАЛЬНОЇ ЕКОНОМІКИ ЯК ФАКТОРУ ВІДНОВЛЕННЯ В ПІСЛЯВОЄННИЙ ПЕРІОД
Authors: Sakun O.S. , Shchur R. I. , Matskiv V.V. , Bilyi M.M.
Published: July 2023

Стаття присвячена аналізу значення формування інвестиційного ресурсу структурної модернізації економіки для післявоєнного відновлення України. В наслідок військових дій через російську агресію національна економіка потерпає сьогодні від кризових проявів та поглибленої регіональної диспропорції, що є суттєвою перешкодою на шляху економічного відновлення та підйому в післявоєнний період.

Ефективною моделлю інтенсивного розвитку національної економіки є динамічне зростання ВВП, що давало б можливість за максимально ідеальних умов забезпечувати постійно зростаючі суспільні потреби. Це зумовлює необхідність дотримання постійних  темпів економічного розвитку в умовах повного застосування вичерпності виробничих ресурсів, в першу чергу, трудових, забезпечення стабільності цін та міцної позиції вітчизняної економіки в межах світового ринку. В умовах післявоєнного відновлення мова йде також про відбудову інфраструктури, але вже за принципово новими сучасними стандартами, що потребує інноваційного підходу.

Метою статті є розкриття теоретико-методологічних засад формування інвестиційного ресурсу та з’ясування  практичних аспектів його значення  для структурної модернізації економіки України в умовах післявоєнного відновлення.

Виходячи з фінансового виснаження країни війною та недостатності бюджетних ресурсів, важливого значення набуває залучення інвестицій. А враховуючи необхідність не просто відновлення, а й інноваційної перебудови, провідну роль в таких процесах набуває інвестиційний ресурс структурної модернізації економіки. Його можна визначити, як динамічну систему підбору та поєднання інформаційно-правових, фінансових, інтелектуальних та  матеріально-технічних компонент, які будуть використані для відновлення та розвитку економічної системи країни в післявоєнний період.

Формування інвестиційного ресурсу структурної модернізації національної економіки через запропоновану онлайн платформу є важливим завданням на шляху післявоєнного відновлення України, що набуває своєї актуальності вже на сучасному етапі. Враховуючи, прогнозований рівень витрат та необхідність інноваційних підходів до процесу відбудови України, інвестиційний ресурс набуває ключового значення для фінансового забезпечення поставлених завдань.
ІТ-АУТСОРСИНГ ЯК СТРАТЕГІЧНИЙ НАПРЯМ РОЗВИТКУ ЕКОНОМІКИ УКРАЇНИ НА ЇЇ ШЛЯХУ ДО СТАЛОГО РОЗВИТКУ
Authors: Korolchuk L.V.
Published: July 2023

В статті піднято проблему необхідності визначення стратегічних напрямів розвитку економіки України напередодні розробки та імплементації післявоєнного плану відновлення нашої держави, який стане потужним каталізатором для розвитку найперспективніших галузей завдяки фінансовій підтримці наших міжнародних партнерів та російським репараціям. За допомогою статистичного аналізу, а також аналізу наукової та довідкової літератури із зазначеної проблематики обґрунтовано доцільність розглядати сферу ІТ-аутсорсингу як пріоритетну в поточних умовах в контексті концепції сталого розвитку, генеральний характер якої для України задекларовано в міжнародних та національних стратегічних документах. Українські аутсорсингові компанії відзначаються високою пізнаваністю і конкурентоспроможністю на світовому та ринку  Східної Європи зокрема. Дана сфера виявилася найбільш стійкою та адаптивною в умовах війни, так як такий бізнес функціональний і без стаціонарного обладнання, і при наявності інтернет зв’язку можливо працювати віддалено з будь-якого місця. ІТ-аутсорсинг відноситься до наукоємних сфер економіки, не передбачає затрат природних невідновлювальних ресурсів, забезпечує робочими місцями висококваліфікованих фахівців з достойною оплатою їх праці, є джерелом валюти у країну, покликаний покращувати умови праці та рівень життя населення в цілому, а отже відповідає меті сталого розвитку.

На основі методів наукового абстрагування, ідеалізації та спостереження досліджено взаємозв’язок між розвитком ІТ-аутсорсингу та Цілями сталого розвитку.

 Алгоритм стратегічного планування визначено методикою стратегічного аналізу, в ході якого здійснено SWOT-аналіз ІТ-аутсорсингу, як сфери економіки України на її шляху до сталого розвитку та, в результаті кількісного співвідношення сильних, слабких сторін, а також можливостей та загроз, обрано оптимальну стратегію для розвитку даної сфери серед потенційно можливих. Визначено перспективи подальших досліджень даної теми у напрямку розробки програм та дорожніх карт в рамках реалізації запропонованої стратегії.
ЗАКОРДОННИЙ ДОСВІД СТИМУЛЮВАННЯ ВПРОВАДЖЕННЯ ІННОВАЦІЙНО-ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ ФІНАНСОВИМИ УСТАНОВАМИ
Authors: Popelo O.V. , Kholiavko N.I.
Published: July 2023

Стаття присвячена аналізу закордонного досвіду стимулювання впровадження інноваційно-інформаційних технологій фінансовими установами для підвищення якості надання фінансових послуг економічним агентам у сучасних умовах. Доведено, що зміни, які створює впровадження інноваційно-інформаційних технологій, спрямовані як на зміну стратегічного фокуса фінансових установ, що призводить до змін на організаційному рівні, так і на рівні фінансової системи в цілому.  На основі досвіду провідних країн світу, окреслено переваги для фінансових установ, які вони отримують за рахунок використання інноваційно-інформаційних технологій, серед яких: підвищення якості надання фінансових послуг споживачам, шляхом полегшення процесу їх отримання, підвищення ціннісної пропозиції, а також пришвидшення процесу отримання цих послуг; можливість використовувати декілька каналів для взаємодії зі споживачами фінансових послуг, а також дистанційний характер відносин; забезпечення стійкості фінансових установ в умовах турбулентності та невизначеності зовнішнього середовища; підвищення задоволеності та набуття досвіду економічних агентів від споживання фінансових послуг; використання персоніфікованого підходу до споживачів фінансових послуг; зниження собівартості фінансових послуг та збільшення прибутковості за рахунок зниження операційних витрат; використання інформації для аналітики; підвищення прозорості та надійності руху фінансових ресурсів та зниження загального рівня ризику. Наведено основні принципи впровадження інноваційно-інформаційних технологій. Проаналізовано можливості та ризики використання фінансовими установами інноваційно-інформаційних технологій, а також розглянуто цифрові технології, що підвищують якість надання фінансових послуг. Окреслено закордонний досвід державних ініціатив зі стимулювання фінансових установ до впровадження інноваційно-інформаційних технологій. Наведено напрями державного стимулювання запровадження цифрових технологій фінансовими установами. Надано практичні рекомендації щодо підвищення якості надання послуг фінансовими установами економічним агентам в нових умовах їх роботи.
ЯКІСТЬ МЕДИЧНИХ ПОСЛУГ: СУТНІСТЬ ТА ІНСТРУМЕНТИ ЗАБЕЗПЕЧЕННЯ
Authors: Kinash I. P. , Savchuk L. M.
Published: July 2023

Стаття спрямована на дослідження сутності поняття «якість медичних послуг» та особливостей застосування інструментів її забезпечення в медичному закладі. Використано наступні методи дослідження: наукового спостереження, абстрактно-логічного аналізу, узагальнення та описовий метод.

Узагальнено позицію науковців стосовно понять «якість», «медична послуга», «якість медичної послуги». З’ясовано, що критерії якості медичних послуг є  специфічними з огляду на властивості та її характеристики. Специфіка медичних послуг проявляється в таких ознаках: невідчутність, невіддільність від джерела надання, незбережність, непостійність якості. Якість медичних послуг розглядається як основна цільова функція і водночас критерій діяльності сфери охорони здоров'я.

Узагальнено найбільш характерні ознаки медичних послуг. З’ясовано, що медичні послуги є дуже специфічні. Їм властиві такі особливості: невідчутність; невіддільність від джерела надання; непостійність якості; незбережність. Акцентовано увагу на те, що якість медичних послуг відображає здатність задовольнити потреби споживача та його очікування. Оцінити якість можна з урахуванням двох складників: задоволеність споживача процесом надання медичних послуг та задоволеність споживача результатом надання медичних послуг. Відтак, зважене та обґрунтоване використання інструментів забезпечення якості медичних послуг є важливим як з позиції суспільства в цілому, так і з позиції діяльності окремих суб’єктів господарювання.

Об’єктом дослідження слугувало комунальне некомерційне підприємство «Центральна міська клінічна лікарня Івано-Франківської міської ради». З’ясовано, що діяльність із забезпечення якості медичних послуг направлена як на клінічний, так і на організаційний аспект. Основними інструментами забезпечення якості медичних послуг є: акредитація, стандартизація, ліцензування та дотримання протоколу для кожної хвороби. Узагальнено результати застосування цих інструментів. Виявлено позитивний результат - покращено якість надання медичних послуг як при обстеженні, так і при лікуванні пацієнтів.
La Transición Española a partir de dos ejemplares de libros de texto de 4º de ESO: ¿Hay espacio para la memoria no hegemónica?
Authors: Uriarte Cuadrado Alexander
Published: July 2023

Encuadramos este trabajo en un contexto de iniciativas encaminadas, desde distintos ámbitos, a la recuperación de la memoria de afectados por procesos traumáticos y de reivindicación del ámbito educativo como uno de los impulsores de dicha labor. Así, considerando la transición española como uno de los procesos más controvertido de la historia actual y el libro de texto como el recurso educativo más recurrido en las aulas, planteamos analizar si hay espacio para la memoria no hegemónica (la de los denominados ‘desencantados’ y la de los afectados por las distintas violencias políticas acaecidas en la época, incluida la de índole estatal) en dos libros de texto de 4º de ESO.
Utilization of weeds and agriwaste by popularizing handpapermaking in Kerala, India
Authors: Nambisan Padma
Published: July 2023

Kerala in south India grows several cash crops such as banana and pineapple, the crop residues of which are sources of natural fibres that can be used in hand papermaking. Kerala, however, does not have a tradition in hand papermaking. The following is an account of an attempt to popularize the art and craft of hand papermaking among self-help groups as a means of self-employment and waste utilization, using fibres extracted from agriwaste and local plants.
Water retention value measurements of cellulosic materials using a centrifuge technique
Authors: Cheng Qingzheng , Wang Jingxin , McNeel Joseph F. , Jacobson Peter M.
Published: July 2023

A centrifugal method has been modified and applied to the assessment of water retention value (WRV) in cellulosic materials. Microcrystalline cellulose (MCC), small particles/fibrils isolated from MCC using high-pressure homogenizer, and pulp fibers saturated in water were centrifuged at different speeds and times with filter paper and/or a membrane acting as the filter in the WRV measurement setup. As centrifugal speed, time, and filter pore-size increased, lower WRVs were obtained. Smaller MCC particles/fibrils retained more water than the as-received MCC and pulp fibers. The results are useful for WRV measurements of cellulosic materials, especially for microfibrillated cellulose and small cellulosic fibrils.
Trends in Teaching Programming in Schools in Hungary
Authors: VISNOVITZ Márton , HORVÁTH Győző
Published: July 2023

Programming education in Hungary has undergone significant changes with the new
National Core Curriculum released in 2020. It introduced a new, revised Digital Culture curriculum in public schools as a successor to the earlier informatics subject. The new curriculum contains several new themes and topics, with a bigger emphasis on programming and algorithms. However, little is known about the effect of these changes on the teaching practices and tools used to teach programming. In this paper, we present the results of a survey conducted with schoolteachers, and data provided by the Educational Authority of Hungary. We identify the most common programming languages, environments and pedagogical methods used by teachers, to give a general overview of the trends in teaching programming in Hungarian public schools.
Impact of an Intervention to Reduce Bronchodilator Use in Bronchiolitis – A Time Series Analysis
Authors: Lawrence Joanna , Hiscock Harriet , Voskoboynik Alice , Walpola Ramesh , Sharma Anurag
Published: July 2023

BACKGROUND AND OBJECTIVES

International guidelines recommend against the use of bronchodilators in bronchiolitis. Despite attempts to address low value care practices in pediatrics, the literature is still evolving regarding which interventions are most effective in low value care reduction. We aim to assess the impact of a multifaceted intervention on rates of bronchodilator prescription in bronchiolitis.

METHODS

With electronic medical record (EMR) data over a 76- month period, we evaluated changes in bronchodilator prescription among infants aged 1 to 12 months diagnosed with bronchiolitis, using interrupted time series analysis, controlling for preintervention prescribing trends. The setting was the emergency department of a large teaching pediatric hospital. The intervention included education, clinician audit-feedback, and an EMR alert, implemented February 2019. The main outcome measure was rate of bronchodilator prescription per month.

RESULTS

There were 9576 infants, aged 1 to 12 months, diagnosed in the emergency department with bronchiolitis over the study period. Bronchodilator ordering reduced from 6.9% to 3.2% after the intervention. Once underlying trends were accounted for, the multifaceted intervention was associated with a reduction in the rate of prescribing (inter-rater reliability 0.98, 95% confidence interval 0.96 to 0.99, P = .037).

CONCLUSIONS

We found that the multifaceted intervention, including an EMR alert, may be an effective method of reducing low value care prescribing in bronchiolitis, accelerating the reduction of unnecessary care and supporting sustainable change.
Effect of five cooking methods on the physicochemical, nutritional and sensory characteristics of rainbow trout (Oncorhynchus mykiss)
Authors: Ramos Miriam , Bustillos Rolys , Ruiz Salomón , Tuesta Tarsila , Silva-Paz Reynaldo , Jordán-Suárez Oscar
Published: July 2023

This study aimed to evaluate the effect of five cooking methods (steam, grill, oven, frying and microwave) on farm-raised rainbow trout's sensory acceptability, physicochemical characteristics, and nutritional value. A survey was conducted with 307 consumers to create a marinade made with salt, garlic, cumin and pepper. The fillets marinated in this mixture were cooked, and photographs were taken to determine their sensory profile using the Check All That Apply (CATA) method, as well as their appearance through both visual (n = 289) and virtual (n = 100) surveys. Similarity was found between the sensory attribute maps for frying, oven and grilling in both evaluation methods. Significant differences (p < 0.05) in proximal composition were observed between the cooking techniques studied because of their technological parameters. The methods with the best visual acceptability were frying and microwave, and they caused an increase in the peroxide index. The n-6/n-3 ratio for both techniques (3.62 and 2.05) was within the requirement, being higher in frying due to the predominance of Omega 6 fatty acids incorporated by the oil used. This study demonstrated that the Peruvian consumer prefers cooking techniques characterized by ease of preparation and marked the development of color and texture attributes.
Geolashon (Teloschistes flavicans), a natural yellow dye from the Peruvian Andes: traditional uses, bioactive extraction, and potential applications
Authors: Padilla Pacahuala German , Barzola Ollero Erick Abel , Quincho Estares José Isrhael , Maceda Santivañez Julio Cesar , Quispe Santivañez Grimaldo Wilfredo , Chagua Rodriguez Perfecto , Salvador-Reyes Rebeca , Chañi-Paucar Larry Oscar
Published: July 2023

Recently, interest in studying pigments from lichens has been aroused due to their bioactive properties and health benefits. The Geolashon (Teloschistes flavicans) is a thousand-year-old lichen from the Peruvian Andes characterized by its yellow filaments, traditionally used by the Peruvian inhabitants as a natural pigment for making handicrafts and medicinal purposes. In this sense, this article aims to compile all the studies on Geolashon as a source of natural yellow pigments, starting from its importance and applications by the Andean population to research on obtaining, characterizing, and properties of its extracts. Although studies on this lichen are limited, it was observed that the obtained from lichen are rich in 3-[1’-(2”,3”-dihydroxy-phenyl)-propyl]-7-hydroxy- chroman-4-one, vicanicin, parietin, other compounds and has antidiabetic, antibacterial, antileukemic, antimicrobial, anticancer and termiticide activity that would be interesting for use in the pharmaceutical, cosmetic, food and agricultural industries, generating added value in the final product. Aspects such as processing, functional properties, and toxicology of the bioactive components of Geolashon must be studied for its correct use.
Service quality and mobile phone user satisfaction in a Peruvian university
Authors: García Camizán Edelia
Published: July 2023

The objective of this study was to determine the relationship between service quality and mobile phone user satisfaction at a Peruvian University. The type of research has a quantitative approach with a non-experimental cross-sectional design. The sample consisted of 149 students of the institution applying a questionnaire of 36 questions with a Likert scale. Likewise, an internal consistency test was carried out through KMO and Bartlett with a significance of 0.00, which indicates that the instrument is valid and the Cronbach's alpha test, yielding a reliability result of 0.958. For the analysis of data distribution under the normality test, the Kolmogorov-Smirnov method was used with a significance level of 0.00, this determines that the distribution is not normal. It is concluded that there is a significant correlation between the variables quality of service and user satisfaction with a p value of 0.00, likewise a Kendall Tau-b correlation coefficient of 0.881 was evidenced, showing a very good and significant correlation between both variables.
Accounts receivable and its incidence on the return on investment in the company in a Peruvian MYPE
Authors: Abad Pintado Jezrielita , Vásquez Julón Norith , Villafuerte de la Cruz Avelino Sebastián
Published: July 2023

Accounts receivable are essential in the return on investment in a company, in this sense the present has as a general objective to determine the influence of accounts receivable on the return on investment, in the company Rotemar EIRL, periods 2019-2021 In this sense, the research awaits a quantitative approach methodology, of a causal or explanatory type, its design is non-experimental and cross-sectional, the financial information of the company was used, from the years 2019-2021. Coming to conclude that accounts receivable (Credit Policies, Collection Policy), has a positive and significant influence on the return on investment, by 54.4%, so it is determined that in the company the accounts receivable is important and their recovery is important because in this way there will be a good return on the investment made.
From “Bangtan Boys” to “International Relations Professor”: Mapping Self‐Identifications in the UN’s Twitter Public
Authors: Aue Luis , Börgel Florian
Published: July 2023

Digitalization and social media established world-encompassing publics that engage with international organizations. While scholarship has analyzed how international organizations communicate with such digital publics, this article determines who participates in these publics. We created a novel dataset to map the UN’s digital public on Twitter and analyzed the bios of 243,168 accounts that have interacted with the UN. Members of this public provide self-identifications (such as researcher, consultant, or scientist) that indicate a professional interest in the UN. We analyzed clusters of users that self-identify with similar words. We find high heterogeneity in the UN’s digital public: Clusters of professional, academic, and organizational users suggest that the technocratic history of international organizations reflects in the members of its digital public. At the same time, the digital public of the UN extends to very different groups (human rights activists and K-Pop fans feature in the UN’s public on Twitter). We demonstrate for future research how multiple correspondence analysis can reveal clusters in unstructured biographical data. The article contributes the first analysis of self-identifications in digital publics of global politics.
Paget disease of skeleton – Pictorial essay
Authors: S Kakarla
Published: July 2023

Paget disease involving the skeleton is considered to be rare in India. It may involve any part of the skeleton from head to toe. Conventional radiology is the best mode of investigation depending upon the bone involved the usual symptoms include pain, swelling and deformity. Radiological features and complications are universal as in other countries. Bone scanning is the final word to determine whether Paget is monostotic or polyostotic. A viral theory has been proposed but no exact etiology is established so far. Keywords: Paget disease; Skeleton; Pictorial essay
Role of TGF-β signaling in tumorigenesis
Authors: A Venkateshwari , C Vinod , A Pratibha Nallari , A Jyothy
Published: July 2023

Transforming growth factor β (TGF β) is one of the crucial cytokine playing an important role in developmental and pathological conditions. TGF β is primarily Smad mediated signal transducers but it can also cross talk with c-Jun N-terminal kinases (JNK), Mitogen-activated protein kinases (MAP), Phosphoinositide 3 (PI-3) kinase, Akt/protein kinase B signaling pathways to enhance cancer development. During early stages of cancer the TGF β induces a protective cytostatic effect. In advanced stages, TGF β fails to down regulate Myc, a transcription factor which represses expression of p21Cip1 and p15Ink4b involved proliferation and differentiation of normal epithelial cells and thus losses its cytostatic property. TGF β also involves in various metastatic processes including angiogenesis, extracellular modification, epithelial-mesenchymal transition, cell migration, immune suppression. Several preclinical animal model studies have encouraging outcomes, suggesting TGF β as a potential therapeutic target in advanced cancers. Keywords: Transforming growth factor β; Smad; c-Jun N-terminal kinase; Mitogen-activated protein kinase; Phosphoinositide 3 kinase
Recent advances in the management of bladder cancer
Authors: Reddy Jayanth
Published: July 2023

Bladder cancer is the commonest malignancy of the urinary tract. Various alternatives have been investigated, either to reduce the frequency of cystoscopy, or improve its sensitivity for detection of tumors. These include urine-based markers, Narrow-band imaging and photodynamic diagnosis/blue-light cystoscopy. Recent developments in post-resection intravesical regimens for non-muscle-invasive bladder cancer are discussed. For patients with muscle-invasive bladder cancer, both laparoscopic radical cystectomy and robot-assisted radical cystectomy have been shown to reduce peri-operative morbidity, while being oncologically equivalent to open radical cystectomy. Bladder-preserving strategies entail resection and chemoradiation, and in selected patients give equivalent results to surgery. These newer approaches are also discussed Keywords: bladder cancer; urine-based markers; Narrow-band imaging; photodynamic diagnosis
Clofarabine, cyclophosphamide, and etoposide (CLOVE) in adult patients with relapsed/refractory acute T-cell lymphoblastic leukemia: single-center experience
Authors: GÜVEN Zeynep Tuğba , TUBAY Şaziye Esra , ÇELİK Serhat , KEKLİK Muzaffer , ÜNAL Ali
Published: July 2023

Purpose: Clofarabine is a second-generation purine analog that inhibits DNA synthesis. It is used as an effective new agent in relapsed refractory acute leukemia. We aimed to report our single center experience about CLOVE protocol as a clofarabine-based regimen in patients with relapsed or refractory T-cell acute lymphoblastic leukemia.

Materials and Methods: Thirteen patients with relapsed or resistant T-cell acute lymphoblastic leukemia were included in this study. Patients were administered clofarabine (40 mg/m2/day), etoposide (100 mg/m2/day), and cyclophosphamide (440 mg/m2/day) (5 days chemotherapy). The patients' data were reviewed retrospectively, the demographic and clinical characteristics of patients were recorded.

Results: The patients' median age was 47, and 77% (n:10) of them were male. The median number of chemotherapy regimens they received before clofarabine was 3. Of the patients, 54% (n=7) presented with relapse, and 46% (n=6) with refractory disease. Hematological side effects were observed in all patients during treatment, and 4 (31%) patients were complicated by febrile neutropenia. Other side effects were hepatotoxicity 39%, skin reaction 2%, nausea 54%, and mucositis 31%. Three (23%) patients were unresponsive to treatment. A response was obtained in 10 (77%) patients. Allogeneic stem cell transplantation was performed in 4 of 5 patients with complete response. The median follow-up time after CLOVE was 2.3 (0.69-26.02) months. The median estimated survival time was 21.04 ± 3.88 (95%CI: 13.43 -28.64) months. Overall survival was 85.7% at three months and 57.1% at one year. Three patients were alive at the end of our study.

Conclusion: The combination of clofarabine, etoposide, and cyclophosphamide (CLOVE) appears to be successful in achieving a response in relapsing or resistant acute leukemia. However, more effective regimens are still needed.
¿Qué enseña el Método de las Ciencias Sociales de Carl Menger a la Contabilidad Emergente?
Authors: Castro Díaz Alexánder , Jaramillo Lotero Rafael Alexánder , Mejía Soto Eutimio
Published: July 2023

El objetivo de este artículo es contribuir al desarrollo teórico y conceptual de la contabilidad emergente, evaluando los desarrollos de la teoría económica desde diferentes escuelas de pensamiento. Mediante una investigación documental, analítica y prescriptiva se identifican en Carl Menger los elementos metodológicos y epistemológicos pertinentes para interpretar la teoría contable. Este autor, fundador de la Escuela Austriaca, es cocreador de la revolución marginalista, clasifica la economía política en tres tipos de ciencias: la histórica; la teórica, que se divide en exacta (racional) y realista (empírica), y la práctica. A la primera pertenecen la historia y la estadística; a la segunda, la economía teórica exacta y empírica, y a la última, la política económica y las finanzas. Los tres campos tienen métodos y funciones diferentes, razón por la cual no es posible formular conceptos de una ciencia unitaria o absoluta. Las primeras ciencias formulan leyes exactas; las segundas, regularidades o leyes empíricas, y las terceras, leyes normativas o reglas establecidas por la autoridad política o la costumbre. Estos lineamientos metodológicos permiten analizar el desarrollo científico del saber contable, que ha tenido una evolución teórica y práctica en función del progreso de la ciencia económica, fundamentalmente de la corriente clásica y neoclásica.  La contabilidad emergente propende por una investigación que permita el ascenso teórico que conduzca a la independencia y autonomía, fortaleciendo sus relaciones epistemológicas, axiológicas y ontológicas, que le permita ampliar su objeto de estudio, función y finalidad.
Upsurge in firearm related deaths among children and adolescent in United States: An alarming trend
Authors: Bashar Mohammad Abu
Published: July 2023

Firearm related injuries and deaths are a major public health challenge in the developed countries such as United States (U.S.). It is one of the most common forms of suicide and homicide. Recent data from the Centers for Disease Control and Prevention (CDC) shows an alarming increase in firearm related mortality among children and Adolescents which is a cause of concern and requires strict gun licensing regulation in countries like U.S.
Samba mudo: saberes sensíveis que a música não fala e a pesquisa não vê nem salvaguarda
Authors: GRAEFF Nina
Published: July 2023

“Samba mudo” foi a expressão usada por sambadores do Recôncavo Baiano ao assistirem a vídeos de 1987 de João da Viola tocando cinco tons de machete. O samba foi chamado de mudo porque os vídeos foram gravados sem canto, de maneira a capturar com clareza aquelas cinco técnicas de execução da pequena viola. A clareza e os objetivos analíticos da pesquisa possibilitaram, décadas depois, reativar um saber em grande parte desaparecido por meio do projeto “Tons de Machete”, que registrou diversos saberes e perspectivas em torno da prática e realidade documentadas nos vídeos através de “encruzilhadas sensíveis”, método aqui apresentado, entre agentes de diferentes lugares e contextos do Brasil e Portugal. Entretanto, ao enfatizar determinados aspectos e discursos de uma prática cultural mais ampla, certas escolhas de registro e de pesquisa podem emudecer saberes, conforme as premissas e percepção do pesquisador. Este artigo é o primeiro de uma série que, ao apresentar resultados do projeto, busca, a partir de pesquisa etnográfica e das vozes de mestres sambadores, amplificar várias dimensões constituintes do fazer musical que escapam a uma percepção eurocêntrica formatada pela Normatividade Musical Ocidental e predominante na pesquisa, ensino e salvaguarda musicais. Além de apresentar o projeto, neste artigo são questionadas narrativas em torno da viola machete como principal objeto de salvaguarda na patrimonialização do samba de roda e discutidos entendimentos amplos dos sambadores acerca do samba e de seus instrumentos, incluindo aspectos cosmológicos condizentes com epistemologias africanas.
Hybrid Gray scale & color medical images compression by Quincunx wavelets and Walsh Hadamard transform
Authors: BOUKLI-HACENE Ismail
Published: July 2023

In recent years, the successful development of hybrid image compression algorithms has typically become a practical necessity for academic researchers. In this extensive research, we properly investigate a novel method for optimally compressing medical grayscale and color images. This method is appropriate mix of Quincunx Wavelet transform (QWT) and Walsh Hadamard Transforms (WHT). The Quincunx wavelet is a novel technique employed to achieve precisely an optimal geometric representation of a specific image. The QWTs were chosen due to their limited number of wavelets in the family and reduced dilatation factor. And the WHT is also used in data compression such as in the H.264 algorithm and for signal processing operations. Our developed novel hybrid algorithm provides competing performance who correctly gives the best significant compression ratio, the best PSNR, MSSIM values, and extremely good compressed image quality compared standards compression medical image.
Effects of dietary administration of mannan oligosaccharides on growth performance, intestinal Vibrio, non-specific immunity and tolerance to low salinity in golden pompano, Trachinotus ovatus (Carangidae)
Authors: Do-Huu Hoang , Nguyen Thi Nguyet Hue , Vo Hai Thi
Published: July 2023

The effects of dietary supplementation with mannan oligosaccharide (MOS) on growth performance, haematological parameters, intestinal Vibrio, immune response, and stress tolerance to low salinity were evaluated in pompano (Trachinotus ovatus). Pompano (9.24 ± 0.15 g) were fed with 0 (control), 0.1, 0.2, 0.4, 0.6%, or 0.8% dietary mannan oligosaccharides for 8 weeks. The results showed that pompano fed 0.1–0.4% MOS had significantly improved (P < 0.039) specific growth rates. Dietary mannan oligosaccharides did not impact the survival rates of pompano (P = 0.192). The WBC was significantly higher in fish fed diets containing 0.1–0.6% MOS. Dietary MOS supplementation increased lymphocytes in pompano (P ≤ 0.042), while it reduced monocytes and basophils (P ≤ 0.019), but MOS did not show any effects on neutrophils and eosinophils (P ≥ 0.064). Intestinal Vibrio counts were reduced in pompano fed diets containing 0.1 to 0.4% MOS supplementation (P ≤ 0.035). The phagocytic ratio (PR) significantly increased in pompano fed diets containing 0.1 to 0.6% MOS (P ≤ 0.015), while the phagocytic index (PIs) and lysozyme in fish fed 0.1 to 0.4% MOS were significantly higher than fish fed control (P ≤ 0.035). There were significant positive correlations between MOS levels and fish growth at days 14, 28, 42, and 56 (P ≤ 0.049). In addition, dietary mannan oligosaccharide levels were highly correlated with blood parameters, intestinal Vibrio, and the immune index. Optimal dietary mannan oligosaccharides requirements for maximal growth of pompano were predicted to be 0.440% at day 21 (R2 = 0.861), 0.385% at day 28 (R2 = 0.877), 0.371% at day 42 (R2 = 0.891) and 0.365% at day 56 (R2 = 0.750), showing a reduction in MOS requirement when fish size increased. Furthermore, optimal MOS concentrations for maximal immunity based on lysozyme were predicted to be 0.431% (R2 = 0.817) at day 56. Also, fish fed 0.1–0.4% MOS showed better resistance against low salinity stress (P ≤ 0.014). In conclusion, the 0.1–0.4% MOS supplementation could effectively enhance the growth, intestinal microbes, immune system, and tolerance capacity to the low salinity of the cultured pompano, T.ovatus.
Design, Implementation and Usability analysis of Patient Empowerment in ADLIFE project via Patient Reported Outcome Measures and Shared Decision Making
Authors: Erturkmen Gokce Banu Laleci , Juul Natassia Kamilla , Redondo Irati Erreguerena , Berastegui Dolores Verdoy , Torre Juan De La , Yuksel Mustafa , Sarigul Bunyamin , Yilmaz Gokhan , Keung Sarah N. Lim Choi , Arvanitis Theodoros N , Syse Thea Damkjaer , Sorknæs Anne Dichmann , Bloemeke Janika , Kaye Rachelle
Published: July 2023

Introduction:
This paper outlines the design, implementation, and usability study results of the patient empowerment process for chronic disease management, using Patient Reported Outcome Measurements and Shared Decision-Making Processes.
Background
The ADLIFE project aims to develop innovative, digital health solutions to support personalized, integrated care for patients with severe long-term conditions such as Chronic Obstructive Pulmonary Disease, and/or Chronic Heart Failure. Successful long-term management of patients with chronic conditions requires active patient self-management and a proactive involvement of patients in their healthcare and treatment. This calls for a patient-provider partnership within an integrated system of collaborative care, supporting self-management, shared-decision making, collection of patient reported outcome measures, education, and follow-up.
Methods
ADLIFE follows an outcome-based and patient-centered approach where PROMs represent an especially valuable tool to evaluate the outcomes of the care delivered. We have selected 11 standardized PROMs for evaluating the most recent patients’ clinical context, enabling the decision-making process, and personalised care planning. ADLIFE project implements the "SHARE approach’ for enabling shared decision-making via two digital platforms for healthcare professionals and patient. We have successfully integrated PROMs and shared decision-making processes to our digital toolbox, based on an international interoperability standard, namely HL7 FHIR. A usability study was conducted with 3 clinical sites with 20 users in total to gather feedback and to subsequently prioritize updates to the ADLIFE toolbox.
Results
User satisfaction is measured in the QUIS7 questionnaire on a 9-point scale in the following aspects: overall reaction, screen, terminology and tool feedback, learning, multimedia, training material and system capabilities. With all the average scores above 6 in all categories, most respondents have a positive reaction to the ADLIFE PEP platform and find it easy to use. We have identified shortcomings and have prioritized updates to the platform before clinical pilot studies are initiated.
Conclusions
Having finalized design, implementation, and pre-deployment usability studies, and updated the tool based on further feedback, our patient empowerment mechanisms enabled via PROMs and shared decision-making processes are ready to be piloted in clinal settings. Clinical studies will be conducted based at six healthcare settings across Spain, UK, Germany, Denmark, and Israel.
Rattus norvegicus reference genome evaluation for hippocampus RNA-seq data analysis
Authors: Priol Christophe Le , Delahaye-Duriez Andrée
Published: July 2023

Background:One of the first steps of a usual RNA-seq data analysis workflow consists in quantifying gene expression by aligning the sequencing reads to a reference genome and counting the aligned reads in its annotated regions. Downstream analysis, such as the identification of differentially expressed genes, strongly rely on the quality of this process. In addition to the performance of alignment methods, the choice of reference genome, when several of them are available, may strongly impact this step.Results:Here, we propose to evaluate the effect of widely used \Rn reference genomes consisting of Ensembl and RefSeq annotations of the Rnor\_6.0 assembly and the ones based on the mRatBN7.2 genome assembly recently published by RefSeq, on a classical differential expression workflow. We re-analyzed published RNA-seq datasets from different hippocampal subregions and revealed that the Ensembl and Refseq reference genome based on the mRatBN7.2 assembly provide an improvement of read mapping statistics. We showed that the RefSeq annotations of this assembly make gene expression quantification and differentially expressed gene identification more reliable thanks to overall longer exon length in comparison with Ensembl annotations. Moreover, we identified specific biologically relevant results using RefSeq annotations of the new genome assembly.Conclusion:Overall, the biological interpretation of the differential expression analysis of the analyzed datasets may be dramatically impacted by the choice of reference genome. Therefore, we believe that this choice should be more carefully addressed and that our approach could extend to other tissues and species.
Opsin variation in a poison frog that shows color-associated behavioral biases
Authors: Howell Kimberly A. , Richards-Zawacki Corinne L.
Published: July 2023

Animals send and receive signals, which are honed by evolution for detection by their intended receiver, for a variety of purposes. For signals used in mate choice, selection should favor those that are easy to detect by the receiving sex’s sensory system(s). Here we test for genetic differences affecting color vision among populations and color morphs of the polytypic poison frog, Oophaga pumilio, a species where both males and females show color-assortative behavioral biases. Opsin genes, expressed in rod and cone cells in the retina, play an important role in the tuning of color vision. We therefore hypothesized that the frog’s behavioral biases may be underlain by differences in the expression or sequences of these genes. To test this, we compared closely related populations of O. pumilio containing red and green morphs to test for convergence in opsin expression and sequence by color. We also compared opsins in sympatric morphs from two polymorphic regions with those of neighboring monomorphic populations to test for differences that would confer improved color discrimination in the polymorphic area. We found no significant differences in opsin expression among red and green populations nor among frogs from one polymorphic (red/blue) zone. However, consistent with our predictions for greater color discrimination, we found greater RH1 expression in frogs from a second polymorphic (red/yellow) region. We found several opsin sequence variants that showed no clear association with color morph, though some mutations were only found in polymorphic populations and some mutations should have significant impacts on color vision in affected individuals. Overall, we found limited evidence that differences in color vision have evolved among distinctly colored O. pumilio populations, though the variation we observed within populations does suggest that the raw material needed for selection to act on color vision is present.
Pulmonary tuberculosis complicated by extensive and multiple ground-glass opacity diagnosed by metagenomic next-generation sequencing in a patient with normal immune function: A case report
Authors: Mao Juanjuan , Jin Qian , Ye Dan , Cheng Weisong , Yang Yide
Published: July 2023

A 53-year-old immune-competent female presented with atypical pulmonary tuberculosis (PTB) imaging complicated by extensive and multiple clear boundary ground-glass opacity (GGO) in both lungs. Conventional diagnostic methods for infectious or non-infectious causes failed to identify the etiology. To further detect the accurate pathogen, bronchoalveolar lavage fluid (BALF) was collected for metagenomic next-generation sequencing (mNGS). Mycobacterium tuberculosis was identified by mNGS, thus the patient was diagnosed with PTB. The GGO lesions were healed after the patient received anti-tuberculosis treatment. In a follow-up after 3 months, the patient’s GGO lesion vanished. Based on these results, we for the first time reported a case of PTB in an immune-competent patient complicated by extensive and multiple GGO. And we found that mNGS was a useful complement to conventional pathogenic diagnostic methods and can be used to diagnose infections of unknown cause.
An Efficient Community Detection Algorithm in Online Social Networks
Authors: han zi-xuan , Shi Lei-lei , Liu Lu , Jiang Liang , Tang Wan , Ayorinde Ayodeji O , Antonopoulos Nick
Published: July 2023

The advent of social networks has brought about a paradigm shift in the conventional modes of social interaction and information exchange. Consequently, there is an increasing scholarly interest in the precise detection of communities and analysis of network structures. However, most of the prevailing methods for community detection suffer from limitations in accuracy and efficiency due to the requirement of manually configuring attribute vector dimensions during the extraction of attribute information. Moreover, these algorithms often neglect the pervasive influence of users within the global network and their capacity to disseminate information, thereby undermining the accuracy of community detection. To address these challenges, this study proposes a novel community detection algorithm, named HL Louvain, which draws upon the Hypertext Induced Topic Search (HITS) technique. The HL Louvain algorithm initially applies graph compression to the entire network and subsequently leverages the HITS algorithm to extract global node characteristics. By combining semantic attribute information with local user features, the algorithm defines the collective influence of users. This, in turn, facilitates accurate community detection by modifying the iterative approach of the conventional Louvain algorithm. Furthermore, the algorithm significantly enhances accuracy and stability by autonomously optimizing the iterative process to determine the dimensionality of the attribute vector and the number of topics within the identified network. Experimental evaluations conducted on three distinct Twitter datasets with varying degrees of complexity, as well as a public dataset, demonstrate that the HL Louvain algorithm outperforms other state-of-the-art algorithms in terms of accuracy and stability.
Enhanced Security protocols for data protection in the Internet of Healthcare Things (IoHTs) using Quantum Key Distribution
Authors: Shyry Prayla , Selvam Venkatesan , Gopinath N
Published: July 2023

The Internet of Healthcare Things is essential for enhancing people's protection, care, and health. Health-related criteria for patients can be remotely tracked and transferred to medical data centers via cloud storage, saving them the trip to the hospital. Additionally, the volume of data processed by Internet of Healthcare Things devices is growing exponentially. Due to the increased revelation of sensitive information, there are many unresolved issues about data security and privacy gathered through Internet of Healthcare Things devices. The requirement to apply machine learning algorithms to massive industrial data is developing as quickly as categorization methods themselves. We offer an Entangled Fuzzy Logic based Quantum Key Distribution for data protection to improve and assess the degree of security such breaches, data integrity, etc. in order to safely store and handle this information in the cloud. Results show that the proposed method enhancing the level of security to the cloud more than 99%, the works remarkably well.
Case report: Long-term survival with anlotinib in a metastatic parathyroid carcinoma patient harboring EGFR-sensitizing mutation
Authors: Ying Yushi , Li Hanning , Xia Wenfei , Cheng Teng , Li Hui , Fu Qiang , Ai Tao , Yang Yan , Zhang Ni , Li Xingrui , Ao Qilin , Du Yaying , Yang Zhifang
Published: July 2023

Parathyroid carcinoma (PC) is a rare and aggressive endocrine malignancy with limited treatment options. Despite the lack of standard management approaches to prevent recurrence and metastasis, current treatments such as chemotherapy and radiotherapy have demonstrated limited efficacy. Here, we report the case of a 54-year-old male patient who presented with a range of symptoms including polydipsia, polyuria, and joint pain. Further examination revealed a neck lump, hypercalcemia, and hyperparathyroidism, leading to a diagnosis of PC after en bloc surgery. Seven months following initial treatment, the patient was found to have local recurrence and distant metastases in the lung, which were subsequently resected via left lateral neck dissection and thoracoscopic wedge resection. Given the rapid progression of the patient's tumors, a 422-gene panel test was conducted, revealing the presence of epidermal growth factor receptor (EGFR) p.L858R (c. T2573G) mutation, which may sensitize the EGFR-TKI response, and PIK3CA p. E545KV(c. G1633A) mutation, which can potentially be targeted by everolimus. Despite treatment with gefitinib and everolimus, neither therapy yielded a response. After multidisciplinary treatment discussions, the patient was advised to undergo a multi-target tyrosine kinase inhibitor, anlotinib, which resulted in continuous survival benefits for 19 months. This case highlights the potential of targeted therapy to achieve long-term survival in cases of PC with distant metastases. It also underscores the importance of precision therapy guided by genome sequencing to identify potential targets for treatment. Further multicenter studies are needed to standardize the treatment of recurrent or metastatic PC.