bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct Bioelectricity Generation from Sago Hampas by Clostridium beijerinckii SR1 Using Microbial Fuel Cell
Authors: Jenol Mohd Azwan , Ibrahim Mohamad Faizal , Kamal Bahrin Ezyana , Kim Seung Wook , Abd-Aziz Suraini
Published: July 2019

Microbial fuel cells offer a technology for simultaneous biomass degradation and biological electricity generation. Microbial fuel cells have the ability to utilize a wide range of biomass including carbohydrates, such as starch. Sago hampas is a starchy biomass that has 58% starch content. With this significant amount of starch content in the sago hampas, it has a high potential to be utilized as a carbon source for the bioelectricity generation using microbial fuel cells by Clostridium beijerinckii SR1. The maximum power density obtained from 20 g/L of sago hampas was 73.8 mW/cm2 with stable cell voltage output of 211.7 mV. The total substrate consumed was 95.1% with the respect of 10.7% coulombic efficiency. The results obtained were almost comparable to the sago hampas hydrolysate with the maximum power density 56.5 mW/cm2. These results demonstrate the feasibility of solid biomass to be utilized for the power generation in fuel cells as well as high substrate degradation efficiency. Thus, this approach provides a promising way to exploit sago hampas for bioenergy generation.
Metal Concentration in Muscle and Digestive Gland of Common Octopus (Octopus vulgaris) from Two Coastal Site in Southern Tyrrhenian Sea (Italy)
Authors: Ariano Andrea , Marrone Raffaele , Andreini Rebecca , Smaldone Giorgio , Velotto Salvatore , Montagnaro Serena , Anastasio Aniello , Severino Lorella
Published: July 2019

Octopus vulgaris constitute an important part of most suitable marine resources for human consumption, however, they can represent a source in chemical contaminants intake such as heavy metals. In this scenario, the aim of the study was the evaluation of the concentration of lead (Pb), cadmium (Cd) and mercury (Hg) in the muscle and digestive gland of octopus caught from two different locations along Campania coast (Castellammare di Stabia and Napoli) and the estimation of their weekly human intake derived from the ingestion of octopus. Analysing 38 samples showed a higher concentration of Pb in the muscle of octopus in Castellammare di Stabia than in Napoli. No statistical differences were reported for Cd, Pb and Hg concentrations in the digestive gland of octopus between two sampling sites. Differences were observed between the two tissue types, with a higher level of Cd and Pb observed in the digestive gland compared with the muscle. Noteworthy, the consumption of muscle from Castellammare di Stabia could increase Pb intake in heavy consumers of local octopus. In conclusion, the present work determines that it is important to improve strategies to minimize environmental pollution sources in these areas.
Synthesis of 6,12-Disubstituted Methanodibenzo[b,f][1,5]dioxocins: Pyrrolidine Catalyzed Self-Condensation of 2′-Hydroxyacetophenones
Authors: Assoah Benedicta , Riihonen Vesa , Vale João R. , Valkonen Arto , Candeias Nuno R.
Published: July 2019

The preparation of unprecedented 6,12-disubstituted methanodibenzo[b,f][1,5]dioxocins from pyrrolidine catalyzed self-condensation of 2′-hydroxyacetophenones is herein described. This method provides easy access to this highly bridged complex core, resulting in construction of two C–O and two C–C bonds, a methylene bridge and two quaternary centers in a single step. The intricate methanodibenzo[b,f][1,5]dioxocin compounds were obtained in up to moderate yields after optimization of the reaction conditions concerning solvent, reaction times and the use of additives. Several halide substituted methanodibenzo[b,f][1,5]dioxocins could be prepared from correspondent 2′-hydroxyacetophenones.
Design, Synthesis and Biological Evaluation of Novel Osimertinib-Based HDAC and EGFR Dual Inhibitors
Authors: Dong Hang , Yin Hao , Zhao Chunlong , Cao Jiangying , Xu Wenfang , Zhang Yingjie
Published: July 2019

Herein a novel series of histone deacetylases (HDACs) and epidermal growth factor receptor (EGFR) dual inhibitors were designed and synthesized based on the structure of the approved EGFR inhibitor osimertinib (AZD9291). Among them, four compounds 5D, 5E, 9D and 9E exhibited more potent total HDAC inhibition than the approved HDAC inhibitor SAHA. However, these compounds only showed moderate to low inhibitory potency towards EGFR with compounds 5E and 9E possessing IC50 values against EGFRWT and EGFRT790M in the micromolar range. 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay revealed the potent antiproliferative activities of compounds 5D, 5E, 9D and 9E, among which 9E was even more potent against HeLa, MDA-MB-231, MDA-MB-468, HT-29 and KG-1 cell lines than SAHA and AZD9291. Further selectivity profile of 9E showed that this compound was not active against other 13 cancer-related kinases and two epigenetic targets lysine specific demethylase 1 (LSD1) and bromodomain-containing protein 4 (BRD4). These results support further structural modification of 9E to improve its EGFR inhibitory activity, which will lead to more potent and balanced HDAC and EGFR dual inhibitors as anticancer agents.
NFBTA: A Potent Cytotoxic Agent against Glioblastoma
Authors: Turkez Hasan , Nóbrega Flávio Rogério da , Ozdemir Ozlem , Bezerra Filho Carlos da Silva Maia , Almeida Reinaldo Nóbrega de , Tejera Eduardo , Perez-Castillo Yunierkis , Sousa Damião Pergentino de
Published: July 2019

Piplartine (PPL), also known as piperlongumine, is a biologically active alkaloid extracted from the Piper genus which has been found to have highly effective anticancer activity against several tumor cell lines. This study investigates in detail the antitumoral potential of a PPL analogue; (E)-N-(4-fluorobenzyl)-3-(3,4,5-trimethoxyphenyl) acrylamide (NFBTA). The anticancer potential of NFBTA on the glioblastoma multiforme (GBM) cell line (U87MG) was determined by 3-(4,5-dimethyl-2-thia-zolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT), and lactate dehydrogenase (LDH) release analysis, and the selectivity index (SI) was calculated. To detect cell apoptosis, fluorescent staining via flow cytometry and Hoechst 33258 staining were performed. Oxidative alterations were assessed via colorimetric measurement methods. Alterations in expressions of key genes related to carcinogenesis were determined. Additionally, in terms of NFBTA cytotoxic, oxidative, and genotoxic damage potential, the biosafety of this novel agent was evaluated in cultured human whole blood cells. Cell viability analyses revealed that NFBTA exhibited strong cytotoxic activity in cultured U87MG cells, with high selectivity and inhibitory activity in apoptotic processes, as well as potential for altering the principal molecular genetic responses in U87MG cell growth. Molecular docking studies strongly suggested a plausible anti-proliferative mechanism for NBFTA. The results of the experimental in vitro human glioblastoma model and computational approach revealed promising cytotoxic activity for NFBTA, helping to orient further studies evaluating its antitumor profile for safe and effective therapeutic applications.
Euphosantianane E–G: Three New Premyrsinane Type Diterpenoids from Euphorbia sanctae-catharinae with Contribution to Chemotaxonomy
Authors: Elshamy Abdelsamed I. , Mohamed Tarik A. , Al-Rowaily Saud L. , Abd-ElGawad Ahmed M. , Dar Basharat A. , Shahat Abdelaaty A. , Hegazy Mohamed-Elamir F.
Published: July 2019

Euphorbia species were widely used in traditional medicines for the treatment of several diseases. From the aerial parts of Egyptian endemic plant, Euphorbia sanctae-catharinae, three new premyrsinane diterpenoids, namely, euphosantianane E–G (1–3), alongside four known triterpenes, 9,19-cyclolanostane-3β,24S-diol (4), 25-methoxycycloartane-3β,24S-diol (5), 25-methylenecycloartan-3β,24R-diol (6), and 25-methylenecycloartan-3β,24S-diol (7), were isolated and identified. The chemical structures were proven depending upon spectroscopic analysis, including FTIR, HRFABMS, and 1D/2D-NMR. The chemotaxonomic significance of the isolated compounds, especially diterpenes from E. sanctae-catharinae compared to those documented from different Euphorbia species was also studied via agglomerative hierarchical clustering (AHC). The Egyptian endemic Euphorbia sanctae-catharina was grouped with E. bupleuroides, E. fidjiana, E. fischeriana, E. pithyusa subsp. cupanii, E. prolifera, and E. seguieriana, where myrsinol diterpenoids were the characteristic compounds.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5
Authors: Mangoni Arduino , Eynde Jean , Jampilek Josef , Hadjipavlou-Litina Dimitra , Liu Hong , Reynisson Jóhannes , Sousa Maria , Gomes Paula , Prokai-Tatrai Katalin , Tuccinardi Tiziano , Sabatier Jean-Marc , Luque F. , Rautio Jarkko , Karaman Rafik , Vasconcelos M. , Gemma Sandra , Galdiero Stefania , Hulme Christopher , Collina Simona , Gütschow Michael , Kokotos George , Siciliano Carlo , Capasso Raffaele , Agrofoglio Luigi , Ragno Rino , Muñoz-Torrero Diego
Published: July 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]
LIR Motif-Containing Hyperdisulfide β-Ginkgotide is Cytoprotective, Adaptogenic, and Scaffold-Ready
Authors: Dutta Bamaprasad , Huang Jiayi , To Janet , Tam James P.
Published: July 2019

Grafting a bioactive peptide onto a disulfide-rich scaffold is a promising approach to improve its structure and metabolic stability. The ginkgo plant-derived β-ginkgotide β-gB1 is a highly unusual molecule: Small, hyperdisulfide, and found only in selected ancient plants. It also contains a conserved 16-amino-acid core with three interlocking disulfides, as well as a six-amino-acid inter-cysteine loop 2 suitable for grafting peptide epitopes. However, very little is known about this recently-discovered family of molecules. Here, we report the biophysical and functional characterizations of the β-ginkgotide β-gB1 from G. biloba. A circular dichroism spectroscopy analysis at 90 °C and proteolytic treatments of β-gB1 supported that it is hyperstable. Data mining revealed that the β-gB1 loop 2 contains the canonical LC3 interacting region (LIR) motif crucial for selective autophagy. Cell-based assays and pull-down experiments showed that β-gB1 is an adaptogen, able to maintain cellular homeostasis through induced autophagosomes formation and to protect cells by targeting intracellular proteins from stress-mediated damage against hypoxia and the hypoxia-reoxygenation of induced cell death. This is the first report of an LIR-containing peptide natural product. Together, our results suggest that the plant-derived β-ginkgotide is cytoprotective, capable of targeting intracellular proteins, and holds promise as a hyperdisulfide scaffold for engineering peptidyl therapeutics with enhanced structural and metabolic stability.
Synthesis, Molecular Docking Analysis, and Carbonic Anhydrase Inhibitory Evaluations of Benzenesulfonamide Derivatives Containing Thiazolidinone
Authors: Zhang Zuo-Peng , Yin Ze-Fa , Li Jia-Yue , Wang Zhi-Peng , Wu Qian-Jie , Wang Jian , Liu Yang , Cheng Mao-Sheng
Published: July 2019

To find novel human carbonic anhydrase (hCA) inhibitors, we synthesized thirteen compounds by combining thiazolidinone with benzenesulfonamide. The result of the X-ray single-crystal diffraction experiment confirmed the configuration of this class of compounds. The enzyme inhibition assays against hCA II and IX showed desirable potency profiles, as effective as the positive controls. The docking studies revealed that compounds (2) and (7) efficiently bound in the active site cavity of hCA IX by forming sufficient interactions with active site residues. The fragment of thiazolidinone played an important role in the binding of the molecules to the active site.
Suitability Evaluation of LaNi5 as Hydrogen-Storage-Alloy Actuator by In-Situ Displacement Measurement during Hydrogen Pressure Change
Authors: Goto Kenta , Hirata Tomoyuki , Yamamoto Isao , Nakao Wataru
Published: July 2019

The swelling ability of LaNi5 for application to hydrogen-storage-alloy (HSA) actuator is discussed through the measurement of the swelling ratio in hydrogen. The HSA actuator is driven by hydrogen pressure change causing the swelling of HSA. LaNi5 is one of the candidate materials for HSA actuators as well as palladium. Some prototypes of HSA actuators using LaNi5 have been fabricated; however, the kinetic swelling ability of LaNi5 itself has been not investigated. In this paper, the authors investigated the static and kinetic swelling ability of LaNi5 powder under hydrogen atmosphere. The results showed that the swelling ratio increased by 0.12 at the phase transition pressure. Response time decreased with an increase in the charged pressure during absorption, while it remained constant during discharge. Reaction kinetics revealed that these swelling behaviors were explained by hydrogen absorption and lattice expansion. The swelling ability of LaNi5 was also compared with that of palladium. The results show that LaNi5 swells 1.8 times more than palladium under 0.5 MPa. LaNi5 is suitable for an actuator driven repeatedly under more than the phase transition pressure. Palladium can be used for one-way-operation actuator even under 0.1 MPa since its response time during the evacuation was much longer than during the pressurization.
Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling
Authors: Li Peng , Li Lanzhi , Zhang Cai , Cheng Xi , Zhang Yi , Guo Yang , Long Miao , Yang Shuhua , He Jianbin
Published: July 2019

Ketosis is a nutritional metabolic disease in dairy cows, and researches indicated that ketonic cows always accompany reproductive problems. When ketosis occurs, the levels of non-esterified fatty acids (NEFAs) and β-hydroxybutyrate (BHBA) in the blood increase significantly. Palmitic acid (PA) is a main component of saturated fatty acids composing NEFA. The aim of this study was to investigate whether high levels of PA and BHBA induce inflammatory responses and regulatory mechanisms in bovine endometrial cells (BEND). Using an enzyme-linked immunosorbent assay, quantitative real-time PCR, and western blotting, we evaluated oxidative stress, pro-inflammatory factors, and the nuclear factor (NF)-κB pathway in cultured BEND cells treated with different concentrations of PA, BHBA, pyrrolidinedithiocarbamate (PDTC, an NF-κB pathway inhibitor), and N-acetylcysteine (NAC, an antioxidant). The content of malondialdehyde was significantly higher, the content of glutathione was lower, and antioxidant activity—glutathione peroxidase, superoxide dismutase, catalase, and total antioxidant capacity—was lower in treated cells compared with control cells. PA- and BHBA-induced oxidative stress activated the NF-κB signaling pathway and upregulated the release of pro-inflammatory factors. Moreover, PA- and BHBA-induced activation of NF-κB-mediated inflammatory responses was inhibited by PDTC and NAC. High concentrations of PA and BHBA induce inflammatory responses in BEND cells by activating oxidative stress-mediated NF-κB signaling.
Application of Biodegradable and Biocompatible Nanocomposites in Electronics: Current Status and Future Directions
Authors: Liu Haichao , Jian Ranran , Chen Hongbo , Tian Xiaolong , Sun Changlong , Zhu Jing , Yang Zhaogang , Sun Jingyao , Wang Chuansheng
Published: July 2019

With the continuous increase in the production of electronic devices, large amounts of electronic waste (E-waste) are routinely being discarded into the environment. This causes serious environmental and ecological problems because of the non-degradable polymers, released hazardous chemicals, and toxic heavy metals. The appearance of biodegradable polymers, which can be degraded or dissolved into the surrounding environment with no pollution, is promising for effectively relieving the environmental burden. Additionally, biodegradable polymers are usually biocompatible, which enables electronics to be used in implantable biomedical applications. However, for some specific application requirements, such as flexibility, electric conductivity, dielectric property, gas and water vapor barrier, most biodegradable polymers are inadequate. Recent research has focused on the preparation of nanocomposites by incorporating nanofillers into biopolymers, so as to endow them with functional characteristics, while simultaneously maintaining effective biodegradability and biocompatibility. As such, bionanocomposites have broad application prospects in electronic devices. In this paper, emergent biodegradable and biocompatible polymers used as insulators or (semi)conductors are first reviewed, followed by biodegradable and biocompatible nanocomposites applied in electronics as substrates, (semi)conductors and dielectrics, as well as electronic packaging, which is highlighted with specific examples. To finish, future directions of the biodegradable and biocompatible nanocomposites, as well as the challenges, that must be overcome are discussed.
Association between Dietary Calcium Intake and Adiposity in Male Adolescents
Authors: Jürimäe Jaak , Mäestu Evelin , Mengel Eva , Remmel Liina , Purge Priit , Tillmann Vallo
Published: July 2019

The aim was to investigate the possible association of dietary calcium intake with adiposity, insulin resistance, and adipocytokine values in adolescent boys. In this cross-sectional study, participants were 123 adolescent boys aged 13–15 years, who were divided into tertiles according to their dietary calcium intake. Dietary calcium intake was assessed using three 24 h dietary recalls. In addition, energy intake, body composition, physical activity (PA), and blood biochemical values were also measured. Mean body fat%, fat mass (FM), trunk FM, trunk fat%, and leptin differed between high and low tertiles of calcium intake after adjustment for age, pubertal stage, and PA. For the entire cohort, mean calcium intake was 786 ± 380 mg/day and was related to body mass index (BMI), FM, and trunk fat% but not to insulin resistance or adipocytokine values after adjusting for possible confounders. In addition, only 15.4% of the participants obtained or exceeded their mean dietary calcium intake requirements. These subjects who met their dietary calcium intake had significantly lower body fat% in comparison with subjects not meeting their dietary calcium intake. Odds ratio of being in the highest tertile of FM, trunk FM, and trunk fat% was 3.2–4.4 (95% confidence interval 1.19–12.47; p < 0.05) times higher for boys in low calcium intake tertile, compared to those boys in high calcium intake tertile. In conclusion, dietary calcium intake is inversely associated with total body and abdominal adiposity values in a specific group of healthy male adolescents with different body mass values.
Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy
Authors: Linhart Birgit , Freidl Raphaela , Elisyutina Olga , Khaitov Musa , Karaulov Alexander , Valenta Rudolf
Published: July 2019

Cow’s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow’s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow’s milk allergens. Here, we provide an overview about the allergen molecules in cow’s milk and the advantages of the molecular diagnosis of IgE sensitization to cow’s milk by serology. In addition, we review current strategies for prevention and treatment of cow’s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.
Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk
Authors: Julibert Alicia , Bibiloni Maria , Bouzas Cristina , Martínez-González Miguel , Salas-Salvadó Jordi , Corella Dolores , Zomeño Maria , Romaguera Dora , Vioque Jesús , Alonso-Gómez Ángel , Wärnberg Julia , Martínez J. , Serra-Majem Luís , Estruch Ramon , Tinahones Francisco , Lapetra José , Pintó Xavier , Lopez-Miranda José , García-Molina Laura , Gaforio José , Matía-Martín Pilar , Daimiel Lidia , Martín-Sánchez Vicente , Vidal Josep , Vázquez Clotilde , Ros Emili , Toledo Estefanía , Becerra-Tomás Nerea , Pórtoles Olga , Pérez-Vega Karla , Fiol Miquel , Torres-Collado Laura , Tojal-Sierra Lucas , Carabaño-Moral Rosa , Abete Itziar , Sanchez-Villegas Almudena , Casas Rosa , Bernal-López María , Santos-Lozano José , Galera Ana , Ugarriza Lucía , Ruiz-Canela Miguel , Babio Nancy , Coltell Oscar , Schröder Helmut , Konieczna Jadwiga , Orozco-Beltrán Domingo , Sorto-Sánchez Carolina , Eguaras Sonia , Barrubés Laura , Fitó Montserrat , Tur Josep , Investigators PREDIMED-PLUS
Published: July 2019

Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55–75 years old, with overweight/obesity and MetS) in the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, α-linolenic acid, and ω-3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and ω-3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3–1.6 times higher for total fat, MUFA, SFA and ω-3 FA intake; low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA; hypertriglyceridemia: 0.7 lower for SFA and ω-3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia.
Diet in the Pathogenesis and Management of Ulcerative Colitis; A Review of Randomized Controlled Dietary Interventions
Authors: Keshteli Ammar Hassanzadeh , Madsen Karen L. , Dieleman Levinus A.
Published: July 2019

Epidemiological and experimental studies have suggested that diet is one of the environmental factors that contributes to the onset and pathophysiology of ulcerative colitis. Although many patients suffering from ulcerative colitis attribute their symptoms or disease relapse to dietary factors, only a few well-designed randomized controlled trials have been done to investigate the role of diet in the management of ulcerative colitis. Here, we review the potential mechanisms of the relationship between diet and pathogenesis of ulcerative colitis and summarize randomized controlled dietary interventions that have been conducted in ulcerative colitis patients.
Role of Hypovitaminosis D in the Pathogenesis of Obesity-Induced Insulin Resistance
Authors: Greco Emanuela A. , Lenzi Andrea , Migliaccio Silvia
Published: July 2019

Obesity and type 2 diabetes have both rapidly increased during the last decades and are continuing to increase at an alarming rate worldwide. Obesity and impaired glucose homeostasis are closely related, and during the last decades of investigation about vitamin D, several clinical and epidemiological studies documented an inverse correlation between circulating vitamin D levels, central adiposity and the development of insulin resistance and diabetes. The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals.
Examining Constructs of Parental Reflective Motivation towards Reducing Unhealthy Food Provision to Young Children
Authors: Johnson Brittany J. , Hendrie Gilly A. , Zarnowiecki Dorota , Huynh Elisabeth K. , Golley Rebecca K.
Published: July 2019

Parents are an ideal target to reduce children’s unhealthy food intake. Motivation is one component of behavior change; however, there is a paucity of research exploring parental motivation in unhealthy food provision. This study aimed to understand the relationships between, and relative importance of, constructs of parents’ reflective motivation and children’s intake of unhealthy foods. An online survey captured parent-rated reflective motivation constructs based on the health action process approach (HAPA) model, and children’s intake of unhealthy food using the short food survey. The HAPA model includes constructs of self-efficacy, risk perception, outcome expectancies, intention, and planning. Structural equation modelling was used to examine relationships between constructs and the HAPA model in its structural form. Four-hundred and ninety-five parents of three to seven-year olds completed the study. Model fit statistics (X2 = 210.03, df = 83, p < 0.001; Comparative fit index (CFI) = 0.96; Tucker Lewis index (TLI) = 0.94) supported suitability of the HAPA model. The HAPA model explained 9.2% of the variance in children’s unhealthy food intake. Constructs of self-efficacy (action to maintenance β = 0.69; maintenance to recovery β = 0.70; maintenance to planning β = 0.82) were found to be the most important constructs for reducing children’s unhealthy food intake, followed by planning (to unhealthy food intake β = −0.32) and intention (to planning β = 0.21). This study provides an initial insight into parental motivation and identifies primary intervention targets to enhance parental motivation to reduce unhealthy food provision, and subsequently children’s unhealthy food intake.
Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review
Authors: Pant Bishweshwar , Park Mira , Park Soo-Jin
Published: July 2019

Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. A drug loaded nanofiber membrane can be prepared via electrospinning using a model drug and polymer solution; however, the release of the drug from the nanofiber membrane in a safe and controlled way is challenging as a result of the initial burst release. Employing a core-sheath design provides a promising solution for controlling the initial burst release. Numerous studies have reported on the preparation of core-sheath nanofibers by coaxial electrospinning for drug delivery applications. This paper summarizes the physical phenomena, the effects of various parameters in coaxial electrospinning, and the usefulness of core-sheath nanofibers in drug delivery. Furthermore, this report also highlights the future challenges involved in utilizing core-sheath nanofibers for drug delivery applications.
Biomedical Applications of Hyaluronic Acid-Based Nanomaterials in Hyperthermic Cancer Therapy
Authors: Kim Subin , Moon Myeong ju , Poilil Surendran Suchithra , Jeong Yong Yeon
Published: July 2019

Hyaluronic acid (HA) is a non-sulfated polysaccharide polymer with the properties of biodegradability, biocompatibility, and non-toxicity. Additionally, HA specifically binds to certain receptors that are over-expressed in cancer cells. To maximize the effect of drug delivery and cancer treatment, diverse types of nanomaterials have been developed. HA-based nanomaterials, including micelles, polymersomes, hydrogels, and nanoparticles, play a critical role in efficient drug delivery and cancer treatment. Hyperthermic cancer treatment using HA-based nanomaterials has attracted attention as an efficient cancer treatment approach. In this paper, the biomedical applications of HA-based nanomaterials in hyperthermic cancer treatment and combined therapies are summarized. HA-based nanomaterials may become a representative platform in hyperthermic cancer treatment.
Role of Protein Self-Association on DNA Condensation and Nucleoid Stability in a Bacterial Cell Model
Authors: S. Dias Rita
Published: July 2019

Bacterial cells do not have a nuclear membrane that encompasses and isolates the genetic material. In addition, they do not possess histone proteins, which are responsible for the first levels of genome condensation in eukaryotes. Instead, there is a number of more or less specific nucleoid-associated proteins that induce DNA bridging, wrapping and bending. Many of these proteins self-assemble into oligomers. The crowded environment of cells is also believed to contribute to DNA condensation due to excluded volume effects. Ribosomes are protein-RNA complexes found in large concentrations in the cytosol of cells. They are overall negatively charged and some DNA-binding proteins have been reported to also bind to ribosomes. Here the effect of protein self-association on DNA condensation and stability of DNA-protein complexes is explored using Monte Carlo simulations and a simple coarse-grained model. The DNA-binding proteins are described as positively charged dimers with the same linear charge density as the DNA, described using a bead and spring model. The crowding molecules are simply described as hard-spheres with varying charge density. It was found that applying a weak attractive potential between protein dimers leads to their association in the vicinity of the DNA (but not in its absence), which greatly enhances the condensation of the model DNA. The presence of neutral crowding agents does not affect the DNA conformation in the presence or absence of protein dimers. For weakly self-associating proteins, the presence of negatively charged crowding particles induces the dissociation of the DNA-protein complex due to the partition of the proteins between the DNA and the crowders. Protein dimers with stronger association potentials, on the other hand, stabilize the nucleoid, even in the presence of highly charged crowders. The interactions between protein dimers and crowding agents are not completely prevented and a few crowding molecules typically bind to the nucleoid.
Material Utilization of Cotton Post-Harvest Line Residues in Polymeric Composites
Authors: Müller Miroslav , Valášek Petr , Kolář Viktor , Šleger Vladimír , Gürdil Gürkan Alp Kagan , Hromasová Monika , Hloch Sergej , Moravec Jaromír , Pexa Martin
Published: July 2019

This paper deals with a research focused on utilization of microparticle and short-fiber filler based on cotton post-harvest line residues in an area of polymeric composites. Two different fractions of the biological filler (FCR—reinforced cotton filler) of 20 and 100 µm and the filler with short fibers of a length of 700 µm were used in the research. The aim of the research was to evaluate mechanical characteristics of composites and adhesive bonds for the purpose of gaining new pieces of knowledge which will be applicable in the area of material engineering and assessing application possibilities of residues coming into being from agricultural products processing. Mechanical properties of the composite material produced by a vacuum infusion and tested at temperatures 20, 40, and 60 °C and adhesive bonds which were exposed to a low-cyclic loading, i.e., 1000 cycles at 30% to 70% from reference value of the maximum strength, were evaluated. Composite systems with the FCR adjusted in 5% water solution of NaOH showed higher strength values on average compared to untreated FCR. Unsuitable size of the FCR led to a deterioration of the strength. The filler in the form of 700 FCR microfibers showed itself in a positive way to composite materials, and the particle in the form of 20 FCR did the same to adhesive bonds. Results of adhesive bond cyclic tests at higher stress values (70%) demonstrated viscoelastic behavior of the adhesive layer.
Microstructural Changes of Aramid Fiber Due to Reaction with Toluene 2,4-diisocyanate under Tension in scCO2
Authors: Kong Haijuan , Xu Qian , Yu Muhuo
Published: July 2019

High modulus aramid fiber, such as Kevlar 49, is conventionally prepared by the heat annealing of high strength aramid fiber under a suitable tension at high temperature, especially higher than 500 °C. This enables the mobility of a rigid molecule chain to be rearranged into a more perfect crystalline or orientation structure under tension. However, annealing decreases the tensile strength, since the thermal degradation of the molecular chain at high temperature cannot be avoided. Kevlar 49 fibers treated in supercritical carbon dioxide (scCO2) under tension could improve their mechanical properties at a low temperature. The effects of the tension on the mechanical properties and structure of the Kevlar 49 fibers were studied by mechanical testing, wide-angle and small-angle X-ray scattering (WAXS, SAXS), and scanning electron microscopy (SEM). The results show that the mechanical properties, crystallinity and orientation of the fiber can be improved when the tension is less than 0.6 cN/dtex, which may be due to the increasing of the mobility of a rigid segment with the help of the plasticization of scCO2 and re-arrangement of macromolecular chain into crystalline and orientation structure under tension. What’s more, the amorphous region also was enhanced by crosslinking reaction of toluene 2,4-diisocyanate (TDI) with the chain end groups of the macromolecules in the amorphous regions. However, a decrease of tenacity was found when the tension was higher than 0.6 cN/dtex, which is because the tension was so high that the microfibril was broken. The results indicated that treating the Kevlar 49 fiber in scCO2 under a suitable tension with TDI as a crosslink agent can simultaneously improve both the tenacity and modulus of the fiber.
Electrospun Sesbania Gum-Based Polymeric N-Halamines for Antibacterial Applications
Authors: Lan Shi , Lu Yaning , Zhang Jinghua , Guo Yanan , Li Chun , Zhao Shuang , Sheng Xianliang , Dong Alideertu
Published: July 2019

Microorganism pollution induced by pathogens has become a serious concern in recent years. In response, research on antibacterial N-halamines has made impressive progress in developing ways to combat this pollution. While synthetic polymer-based N-halamines have been widely developed and in some cases even commercialized, N-halamines based on naturally occurring polymers remain underexplored. In this contribution, we report for the first time on a strategy for developing sesbania gum (SG)-based polymeric N-halamines by a four-step approach Using SG as the initial polymer, we obtained SG-based polymeric N-halamines (abbreviated as cSG-PAN nanofibers) via a step-by-step controllable synthesis process. With the assistance of advanced techniques, the as-synthesized cSG-PAN nanofibers were systematically characterized in terms of their chemical composition and morphology. In a series of antibacterial and cytotoxicity evaluations, the as-obtained cSG-PAN nanofibers displayed good antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as low cytotoxicity towards A549 cells. We believe this study offers a guide for developing naturally occurring polymer-based antibacterial N-halamines that have great potential for antibacterial applications.
Coffee Pulp: A Sustainable Alternative Removal of Cr (VI) in Wastewaters
Authors: Gómez Aguilar Dora Luz , Rodríguez Miranda Juan Pablo , Esteban Muñoz Javier Andrés , Betancur P. Jhon Fredy
Published: July 2019

Currently, agricultural waste is proposed as a sustainable alternative in the removal of heavy metals present in industrial wastewater, to fulfill some of the goals proposed in the Sustainable Development Goals stated for the 2030 Agenda, in particular in Sections 3.9 and 6.9. Considering this context, the coffee pulp (Castilla variety) of Caldas municipality (Colombia) was used in study for the removal of one of the most toxic chemical species of chromium: Cr (VI). Therefore, the agricultural residue was subjected to a bromatological characterization, determination of the lignocellulosic composition and elucidation of characteristic organic functional groups by IR spectrophotometry. Additionally, the optimal parameters for contaminant removal were identified, regarding particle size, biomass quantity, optimum pH, stirring time, temperature, adsorption kinetics, zero charge potential (pHpzc) and adsorption isotherms, to analyze the kinetic model that fitted the process, the explanation of the possible adsorption mechanism between the contaminant, the surface of the coffee pulp and the capacity of maximum adsorption, respectively. Finally, the innovation of the research is discussed considering two criteria: First, when a mixture was made in different proportions between two agricultural residues (coffee pulp and plantain pseudostem) to show if there was an increase in the removal of the contaminant under the same optimal conditions found experimentally; and the second criterion, the comparison of the maximum adsorption capacity, with the percentages of removal carried out by other authors using the pulp of unmodified coffee.
CO2 Hydrogenation to Methanol by a Liquid-Phase Process with Alcoholic Solvents: A Techno-Economic Analysis
Authors: Nieminen Harri , Laari Arto , Koiranen Tuomas
Published: July 2019

Synthesis of methanol from recirculated CO2 and H2 produced by water electrolysis allows sustainable production of fuels and chemical storage of energy. Production of renewable methanol has, however, not achieved commercial breakthrough, and novel methods to improve economic feasibility are needed. One possibility is to alter the reaction route to methanol using catalytic alcoholic solvents, which makes the process possible at lower reaction temperatures. To estimate the techno-economic potential of this approach, the feasibilities of the conventional gas-phase process and an alternative liquid-phase process employing 2-butanol or 1-butanol solvents were compared by means of flowsheet modelling and economic analysis. As a result, it was found that despite improved methanol yield, the presence of solvent adds complexity to the process and increases separation costs due to the high volatility of the alcohols and formation of azeotropes. Hydrogen, produced from wind electricity, was the major cost in all processes. The higher cost of the present, non-optimized liquid-phase process is largely explained by the heat required in separation. If this heat could be provided by heat integration, the resulting production costs approach the costs of the gas-phase process. It is concluded that the novel reaction route provides promising possibilities, but new breakthroughs in process synthesis, integration, optimization, and catalysis are needed before the alcoholic solvent approach surpasses the traditional gas-phase process.
Selective Cesium Adsorptive Removal on Using Crosslinked Tea Leaves
Authors: Yu Dan , Morisada Shintaro , Kawakita Hidetaka , Ohto Keisuke , Inoue Katsutoshi , Song Ximing , Zhang Guolin
Published: July 2019

To remove the radioactive cesium from the polluted environment, tea leaves were chosen as cheap, and abundantly available environment-friendly bio-adsorbents to investigate the alkali metals adsorption. Fresh and used tea leaves (FT and UT) were found to have high efficiency and selectivity for cesium adsorption, after the crosslinking with concentrated sulfuric acid. Calculation of the proton-exchanged amount suggested adsorption mechanism of three alkali metals on crosslinked tea leaves involve a cationic exchange with a proton from the hydroxyl groups of the crosslinked tea leaves, as well as coordination with ethereal oxygen atoms to form the chelation. Further, considering the practical application of the polluted water treatment, the competitive adsorption of Cs+ and Na+ ions was investigated by the batch-wise method and column chromatography separation. Unlike the conventional ion exchange and chelate resins with less selectivity for Cs+ coexisting cations, both crosslinked fresh tea leaves (CFT) and crosslinked used tea leaves (CUT) exhibited Cs selectivity over Na. In addition, batch adsorption studies revealed that the cesium adsorptions were driven by the Langmuir isotherm model; the capacity of both crosslinked tea leaves for cesium adsorption was determined to be around 2.5 mmol g−1. The adsorption capacities are sufficiently higher in comparison with those of synthetic polymers, inorganic ion-exchangers, and other bio-adsorbents.
Irregularity Molecular Descriptors of Hourglass, Jagged-Rectangle, and Triangular Benzenoid Systems
Authors: Hussain Zafar , Rafique Shazia , Munir Mobeen , Athar Muhammad , Chaudhary Maqbool , Ahmad Haseeb , Min Kang Shin
Published: July 2019

Determining the degree of irregularity of a certain molecular structure or a network has been a key source of interest for molecular topologists, but it is also important as it provides an insight into the key features used to guess properties of the structures. In this article, we are interested in formulating closed forms of irregularity measures of some popular benzenoid systems, such as hourglass H (m, n), jagged-rectangular J (m, n), and triangular benzenoid T (m, n) systems. We also compared our results graphically and concluded which benzenoid system among the above listed is more irregular than the others.
The Economic Impacts of Open Science: A Rapid Evidence Assessment
Authors: Fell Michael J.
Published: July 2019

A common motivation for increasing open access to research findings and data is the potential to create economic benefits—but evidence is patchy and diverse. This study systematically reviewed the evidence on what kinds of economic impacts (positive and negative) open science can have, how these comes about, and how benefits could be maximized. Use of open science outputs often leaves no obvious trace, so most evidence of impacts is based on interviews, surveys, inference based on existing costs, and modelling approaches. There is indicative evidence that open access to findings/data can lead to savings in access costs, labour costs and transaction costs. There are examples of open science enabling new products, services, companies, research and collaborations. Modelling studies suggest higher returns to R&D if open access permits greater accessibility and efficiency of use of findings. Barriers include lack of skills capacity in search, interpretation and text mining, and lack of clarity around where benefits accrue. There are also contextual considerations around who benefits most from open science (e.g., sectors, small vs. larger companies, types of dataset). Recommendations captured in the review include more research, monitoring and evaluation (including developing metrics), promoting benefits, capacity building and making outputs more audience-friendly.
Urban Forest Growth and Gap Dynamics Detected by Yearly Repeated Airborne Light Detection and Ranging (LiDAR): A Case Study of Cheonan, South Korea
Authors: Choi Heejoon , Song Youngkeun , Jang Youngwoon
Published: July 2019

Understanding forest dynamics is important for assessing the health of urban forests, which experience various disturbances, both natural (e.g., treefall events) and artificial (e.g., making space for agricultural fields). Therefore, quantifying three-dimensional changes in canopies is a helpful way to manage and understand urban forests better. Multitemporal airborne light detection and ranging (LiDAR) datasets enable us to quantify the vertical and lateral growth of trees across a landscape scale. The goal of this study is to assess the annual changes in the 3-D structures of canopies and forest gaps in an urban forest using annual airborne LiDAR datasets for 2012–2015. The canopies were classified as high canopies and low canopies by a 5 m height threshold. Then, we generated pixel- and plot-level canopy height models and conducted change detection annually. The vertical growth rates and leaf area index showed consistent values year by year in both canopies, while the spatial distributions of the canopy and leaf area profile (e.g., leaf area density) showed inconsistent changes each year in both canopies. In total, high canopies expanded their foliage from 12 m height, while forest gap edge canopies (including low canopies) expanded their canopies from 5 m height. Annual change detection with LiDAR datasets might inform about both steady growth rates and different characteristics in the changes of vertical canopy structures for both high and low canopies in urban forests.
Galileo Single Point Positioning Assessment Including FOC Satellites in Eccentric Orbits
Authors: Robustelli Umberto , Pugliano Giovanni
Published: July 2019

On August 2016, the Milena (E14) and Doresa (E18) satellites started to broadcast ephemeris in navigation message for testing purposes. As the Galileo constellation is not yet complete. It is very important to have two more satellites available since the position accuracy increases as the number of visible satellites increases. In this article, we examine how the inclusion of the Milena (E14) and Doresa (E18) satellites impacts the position accuracy. The analysis was carried out on 20 days of 1-Hz observations collected by a receiver placed in YEL2IGS (International GNSS service) station. Two different scenarios are considered: the first excludes the measurements coming from the analyzed satellites, while the second one includes them. The analysis was conducted by using a suitable software tool developed in the MATLAB® environment able to compute satellites position from both the broadcast and precise ephemerides, to assess DOP (Dilution Of Precision) parameters and to compute single-point positioning for all Galileo frequencies. The analyses are conducted by using both broadcast and precise ephemeris. The inclusion of the two satellites improves the system availability, varying it from 94.1–97.94%, the DOP parameters, and the percentages of achieved positioning solutions by about 5% regardless of the frequency used. Nevertheless, in the positioning domain, when the broadcast ephemerides are used, the inclusion of the satellites worsens both the horizontal and vertical accuracy of the solution. The deterioration of the horizontal accuracy goes from 0.17 m with E5a frequency measurements to 0.74 m with E1 measurements. The reduction of vertical accuracy goes from 0.68 m for E5a to 1.2 m for E1 measurements. However, if precise ephemerides are used, both the horizontal and the vertical accuracy remain stable, actually for the E5b frequency, the DRMS (Distance Root Mean Squared) improves by almost 0.5 m. The results achieved show that the real drawback to overcome is related to the quality of broadcast ephemeris as, when precise ephemeris are used, the number of solutions achieved is increased by about 5% with an accuracy similar to that obtained when the satellites are excluded.