bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced Hyaluronic Acid Production from Priestia flexa N7 Isolates
Authors: Vu Dinh Giap , van Do Thi Cam , Thi Linh Mai Dau , Dang Danh Phong , Khuat Bich Ngoc Thi , Thi Oanh Kim Hoang , Do Thu Minh , Ha Thi Dung , Mac The Vinh , Nguyen Phuong Dai Nguyen
Published: March 2024

Background:

Hyaluronic acid (HA) is a gel-like substance made up of glucuronic acid and N-acetylglucosamine units, capable of absorbing and retaining water, present in hydrated gel form across human and animal tissues. It aids in joint lubrication and moisture retention and acts as a cushion for shock absorption. HA has unique biological properties, promoting fibroblast cell growth, aiding wound healing, and exhibiting low solubility and viscosity, making it an organic ingredient in tissue culture techniques. It is utilized in eye drops and skin ointments and plays a vital role in the extracellular matrix, rendering it invaluable in medical and cosmetic applications, such as treating osteoarthritis and enhancing skin wound recovery.

Methods:

The methods employed in this study involve isolating microorganisms, screening bacterial strains capable of synthesizing HA, identifying bacteria using molecular biological methods, and researching optimal conditions to select bacterial strains that produce the highest HA concentrations.

Results:

In this study, strain Priestia
flexa N7 was studied for suitable conditions for HA biosynthesis. Bacterial strains were fermented for 48 h on medium containing the following ingredients: glucose (60 g/L); yeast extract (5.0 g/L); peptone (20 g/L); K2HPO4 (2.0 g/L); Na2HPO4 (1.0 g/L); NaCl (2.0 g/L); FeSO4 (1.0 g/l); sodium glutamate (9.0 g/L); and MgSO4.7H2O (2.0 g/L) and pH 8.0 at 37°C under the condition of continuous shaking at 150 rpm. The maximum HA production achieved was 1105 mg/L.

Conclusions:

The mentioned bacterial strain exhibits significant potential for HA synthesis and is extensively employed in producing items across the health care, medical, food, and cosmetic industries. These findings revealed the most effective HA acid manufacturing strategy for achieving maximum output.
Cytotoxic and Antioxidant Properties of Artemisia deserti Essential Oil Obtained by Different Extraction Methods
Authors: Mollaei Saeed , Shamsuzan Ali , Ghanavi Jalaledin
Published: March 2024

Background:

ArtemisiadesertiKrasch belongs toAsteraceaefamily, and has many medicinal properties that used to treat a variety of diseases, including antihypertensive, invigorating blood circulation, antiallergy, antiviral, antitumor, and antioxidant.

Methods:

The objective of this study was the evaluation of cytotoxic and antioxidant activities as well as the chemical composition ofA.desertiessential oil extracted by different extraction methods. These extraction methods included hydro-distillation (HD), salt-HD (Salt pretreatment followed by HD), maceration-HD (maceration pretreatment followed by HD), acid-HD (acid pretreatment followed by HD), ultrasound-HD (ultrasound pretreatment followed by HD), and enzyme-HD (enzyme pretreatment followed by HD).

Results:

The results revealed that the highest yield of essential oil was achieved by acid-HD (0.48% ± 0.11%). In all methods, the main compounds of essential oil were camphor (44.32%–66.80%), piperiton (14.11%–24.33%), and 1,8-cineole (4.85%–6.75%). The antioxidant property of essential oils was investigated using the DPPH method. Based on the results, the essential oils extracted by acid-HD and enzyme-HD methods had the highest property. The cytotoxic property ofA.desertiessential oils was evaluated. The results demonstrated that the essential oil extracted by enzyme-HD indicated the highest cytotoxicity activity against human cervical carcinoma (HeLa) cells in both 24 and 48 h. Based on the gas chromatography-mass spectrometry results, 1,8-cineol, carvacrol, thymol, and myristicin were rich in the essential oil extracted by enzyme-HD, and the highest cytotoxicity activity of essential oil obtained by enzyme-HD method is probably related to these compounds.

Conclusion:

In addition, it was observed that enzyme-HD is an effective method in the extraction of essential oil with the highest antioxidant and cytotoxic activities.
Comparison between three methods of diode laser 810 nm, photodynamic therapy with laser 660 nm, and hypochlorite solution for disinfection of pulp canal of primary teeth
Authors: Tehrani Nima Amini , Javadinejad Shahrzad , Shirani Amir Mansour
Published: March 2024

Background:

The presence of treatment-resistant microorganisms is known as the main cause of pulpectomy failure in the endodontic treatment of deciduous teeth. The usage of lasers can contribute to reducing these microorganisms. This study aimed to compare the effect of three disinfection methods for deciduous teeth canals using laser diode 810 nm, photodynamic therapy with laser 660 nm and methylene blue, and sodium hypochlorite.

Materials and Methods:

In this experimental study, 58 single-root deciduous teeth with no root resorption were investigated in four groups, including one control group of 10 and three intervention groups of 16. Preparation of the samples was done using manual files up to three numbers after the initial file. After sterilizing the samples in an autoclave, Enterococcus faecalis bacteria were cultured in the canals. In the first group, irrigating with hypochlorite 2.5% was done; in the second group, photodynamic therapy was performed using a laser diode and 0.1 mg/mL methylene solution; and in the third group, high-intensity laser 810 nm direct radiation was done into the canal. Next, samples were taken from all canals. The colony formation unit (CFU) of the bacteria was counted in the blood agar culture medium. The data were analyzed using Kruskal-Wallis and negative binomial regression test (α =0.05).

Results:

The mean CFU differed significantly between the four groups. The rate of incidence of E. faecalis colonies showed a reduction in all three intervention groups compared to the negative control. In the high-intensity laser 810 nm group, there was 68.4%; in the photodynamic therapy with diode 660 nm and methylene blue, there was 88%; and in the hypochlorite group, 98.3% reduction was observed compared to the negative control group.

Conclusion:

Based on the results of this study, to compare three disinfection methods of the deciduous teeth canals without preparation of canals, sodium hypochlorite had greater efficiency. All three groups of laser, photodynamic therapy, and sodium hypochlorite showed reductions of E. faecalis bacterial colony compared to the control group. The reductive effects of CFU were greater in the hypochlorite sodium group, followed by photodynamic and direct laser radiation groups.
Roseomonas Mucosa Bacteremia in an Immunocompetent Child
Authors: Agrawal Sonu Kumari , Tarai Bansidhar , Sehgal Saloni , Goldar Shalini
Published: March 2024

We report a case of bacteremia associated with Roseomonas mucosa isolated from an immunocompetent pediatric patient with no prior history of infection and bacteremia.
Normative Values of Static-dynamic Plantar Pressure and its Cutoff Values
Authors: Patel Hemal M. , Balaganapathy M.
Published: March 2024

Pressure measurement technology is being increasingly used by physical therapists, podiatric physicians, and surgeons in both clinical practice and research. Plantar pressure was recently proposed as a strong predictor of adverse outcomes. Few reviews have been conducted to identify a standard for the plantar pressure in healthy participants, older people, and children. The aims of this study were to explore currently available normative values of static-dynamic plantar pressure and its cutoff values. The SCOPUS, Rehabilitation, MEDLINE, EBSCO, PEDro, and PubMed electronic databases were systematically searched from January 2000 to December 2022. All articles were analyzed using a standardized template to extract various data, such as the first author's details, publication year, country of origin, participant age and gender, sample size, population characteristics, instrument used for measurement, plantar pressure distribution (PPD) type, normative data, and cutoff values. In literature review, the researchers selected nine studies, and in all studies, they selected different areas of foot for normative values. Areas selected for PPD were forefoot, hallux, big toe, second toe, third through fifth toes, toes 2–5, metatarsal 1–5, lateral forefoot, middle forefoot, medial forefoot, midfoot, lateral midfoot, medial forefoot, lateral area of the heel, medial area of the heel, heel, right foot total, left foot total, and right + left total. Age, gender, and body mass index (BMI) affect the results of the plantar pressure. It is necessary to take age, gender, and BMI into consideration when conducting stratified physical evaluations for the evaluation of older people individuals’ screening and outcome.
Hormonal Catalysts in the Addiction Cycle of Muscle Dysmorphia: A Neuroendocrine Perspective
Authors: Çınaroğlu Metin
Published: March 2024

Muscle dysmorphia (MD) is a subtype of body dysmorphic disorder characterized by an obsessive belief that one’s body is insufficiently muscular. This review provides a comprehensive examination of the addiction cycle in MD, particularly in the context of anabolic steroid and performance-enhancing drug (PED) use. Utilizing a systematic search across databases such as PubMed, PsycINFO, Scopus, and Web of Science, the review draws on peer-reviewed literature published in the past two decades to uncover the roles of hormonal and neural alterations in perpetuating this cycle. Inclusion and exclusion criteria were meticulously applied to ensure a robust analysis of relevant studies. The article details the interaction between exogenous hormonal supplementation from steroids and PEDs and brain receptors, which significantly disrupt neurotransmitter systems and affect mood, cognition, and stress responses. The synthesis of data reveals that hormonal imbalances due to substance abuse lead to profound changes in brain plasticity and function, instigating psychiatric disorders and complicating withdrawal and treatment. Therapeutic strategies are critically assessed, with emphasis on the success of cognitive-behavioral therapy, the role of pharmacological management, and the promise of emerging treatments targeting neuroendocrine disruptions. The review suggests an integrated, holistic treatment model that includes hormonal therapy and neurological considerations, underscoring the importance of personalized and sustained interventions. In conclusion, the intricate cycle of addiction in MD, fueled by the hormonal effects of steroids and PEDs on the brain, calls for an integrated approach to treatment. Future research should focus on the neuroendocrine impact of these substances to refine therapeutic strategies for MD.
Anticonvulsant Effects and Histopathological Changes in the Hippocampus of Pentylenetetrazole (PTZ)-induced Epileptic Mice Model following Mentat Treatment
Authors: Ekpo Ubong Udeme , Igiri Anozeng Oyono
Published: March 2024

Background:

Epilepsy is a neurological illness that disturbs the central nervous system and is characterized by regular convulsions. Over 70 million people worldwide are thought to have epilepsy, with the prevalence rate estimated to be around 1%.

Aims:

The objective of this study was to assess antiepileptic activities and histological changes after Mentat administration in the hippocampus of pentylenetetrazole (PTZ)-induced seizure mice.

Materials and Methods:

Twenty Swiss albino mice (18–28 g) were divided into four groups (n = 5) and were given the following intraperitoneally, 2 ml/kg distilled water and 50 mg/kg PTZ to Groups 1 and 2 animals, respectively. Groups 3 and 4 animals were given 200 mg/kg and 400 mg/kg of Mentat, respectively, 1 h before the administration of PTZ and were observed for 300 s. After the experiment, all surviving animals in the various groups were humanely sacrificed and the brains were harvested and preserved in 10% buffered formalin. The brain tissues were processed using routine histological procedures and stained with hematoxylin and eosin.

Results:

Results of this revealed that Mentat was able to delay the onset time of seizure and offered quantal protection to the animals. Mentat also showed a dose-dependent ameliorative effect against histological changes following PTZ administration in mice.

Conclusion:

Mentat attenuates PTZ-induced seizure in mice.
How Entropy Explains the Emergence of Consciousness: The Entropic Theory
Authors: Lugten Peter Cornelis
Published: March 2024

Aim:

Emergentism as an ontology of consciousness leaves unanswered the question as to its mechanism. I aim to solve the body–mind problem by explaining how conscious organisms emerged on an evolutionary basis at various times in accordance with an accepted scientific principle through a mechanism that cannot be understood, in principle.

Proposal:

The reason for this cloak of secrecy is found in a seeming contradiction in the behavior of information with respect to the first two laws of thermodynamics. Information, the microstate of particles within an isolated system’s macrostate, can, like first-law energy, be neither created nor destroyed, yet the information in the system, like second-law entropy, will inevitably increase. To explain information increasing without being created, Laplace’s demon is invoked, able to predict where each particle is destined. This doesn’t work for emerging events like consciousness, which are unpredictable. This can be understood in terms of the derivation of entropy, and the emergence of classical physics, from the Relativistic Transactional Interpretation of Quantum Mechanics. I propose that the increased entropy in a time-irreversible, unpredictable (emergent) isolated system requires the simultaneous deletion of information concerning the steps, or calculations, involved.

Conclusion:

Thus, the steps leading to consciousness are immediately destroyed and must remain a mystery. Implications include that entropy, not panpsychism, is the universal principle generative of consciousness, that our being conscious proves that we are not predetermined, and that consciousness requires assuming an “entropy debt” that can only be repaid by living organisms, prohibiting the emergence of conscious machines.
N-of-1 medicine
Authors: Wang Peter , Leong Qiao Ying , Lau Ni Yin , Ng Wei Ying , Kwek Siong Peng , Tan Lester , Song Shang-Wei , You Kui , Chong Li Ming , Zhuang Isaiah , Ong Yoong Hun , Foo Nigel , Tadeo Xavier , Kumar Kirthika Senthil , Vijayakumar Smrithi , Sapanel Yoann , Raczkowska Marlena Natalia , Remus Alexandria , Blasiak Agata , Ho Dean
Published: March 2024

The fields of precision and personalised medicine have led to promising advances in tailoring treatment to individual patients. Examples include genome/molecular alteration-guided drug selection, single-patient gene therapy design and synergy-based drug combination development, and these approaches can yield substantially diverse recommendations. Therefore, it is important to define each domain and delineate their commonalities and differences in an effort to develop novel clinical trial designs, streamline workflow development, rethink regulatory considerations, create value in healthcare and economics assessments, and other factors. These and other segments are essential to recognise the diversity within these domains to accelerate their respective workflows towards practice-changing healthcare. To emphasise these points, this article elaborates on the concept of digital health and digital medicine-enabled N-of-1 medicine, which individualises combination regimen and dosing using a patient’s own data. We will conclude with recommendations for consideration when developing novel workflows based on emerging digital-based platforms.
Esophageal motor abnormalities in gastroesophageal reflux disorders
Authors: Lei Wei-Yi , Yi Chih-Hsun , Liu Tso-Tsai , Hung Jui-Sheng , Wong Ming-Wun , Chen Chien-Lin
Published: March 2024

Gastroesophageal reflux disease (GERD), a prevalent condition with multifactorial pathogenesis, involves esophageal motor dysmotility as a key contributing factor to its development. When suspected GERD patients have an inadequate response to proton-pump inhibitor (PPI) therapy and normal upper endoscopy results, high-resolution manometry (HRM) is utilized to rule out alternative diagnosis such as achalasia spectrum disorders, rumination, or supragastric belching. At present, HRM continues to provide supportive evidence for diagnosing GERD and determining the appropriate treatment. This review focuses on the existing understanding of the connection between esophageal motor findings and the pathogenesis of GERD, along with the significance of esophageal HRM in managing GERD patients. The International GERD Consensus Working Group introduced a three-step method, assessing the esophagogastric junction (EGJ), esophageal body motility, and contraction reserve with multiple rapid swallow (MRS) maneuvers. Crucial HRM abnormalities in GERD include frequent transient lower esophageal sphincter relaxations, disrupted EGJ, and esophageal body hypomotility. Emerging HRM metrics like EGJ-contractile integral and innovative provocative maneuver like straight leg raise have the potential to enhance our understanding of factors contributing to GERD, thereby increasing the value of HRM performed in patients who experience symptoms suspected of GERD.
Арифметика некоторых $\ell$-расширений с тремя точками ветвления. IV
Authors: Kuz'min Leonid Viktorovich
Published: March 2024

Пусть $\ell$ - регулярное простое нечетное число, $k$ - поле деления круга на $\ell$ частей и $K=k(\sqrt[\ell]{a})$, где $a$ - натуральное число, имеющее ровно три различных простых делителя. В предположении, что в расширении $K_\infty/k_\infty$ разветвлены ровно три точки, мы изучаем $\ell$ компоненту группы классов поля $K$. Доказано,что в случае $\ell>3$ всегда существует неразветвленное расширение $\mathcal{N}/K$ такое, что $G(\mathcal{N}/K)\cong (\mathbb Z/\ell\mathbb Z)^3$ и в расширении $\mathcal{N}/K$ вполне распадаются все простые точки, лежащие над $\ell$. В случае, когда $\ell=3$ и $a$ имеет вид $a=p^rq^s$, полностью описано возможное строение $\ell$-компоненты группы классов поля $K$.
Получены некоторые другие результаты.
Библиография: 6 наименований.
A Narrative Review: Transforming Pediatric Oncology Care Through Virtual Reality - Pain Management and Enhanced Patient Experience
Authors: Abdelkhalik Mohamad , Boueri Myriam , Nasr Leah , Khater Christina
Published: March 2024

Virtual reality (VR) technology has received considerable interest in the healthcare field, particularly in pediatric oncology. Thepurpose of this study was to examine the existing and future applications of VR in reducing the discomfort associated withpediatric oncology procedures such as bone marrow biopsy, bone marrow aspirate, and lumbar puncture. A comprehensive search was conducted across numerous databases from 2005 to 2023, embracing several study designs to provide a strong evidence foundation. Using diversion and relaxation strategies, VR can help pediatric cancer patients cope with the emotional issues they confront during operations. VR has shown significant potential for lowering pain and anxiety during several pediatric medical procedures. Patient feedback focused on VR’s empowering and anxiety-reducing benefits, while healthcare staff reported increased patient participation and procedural efficiency. VR implementation challenges include the cost of specialized technology, the need for specific virtual settings, and the need for training healthcare workers. VR shows promise in improving the pediatric cancer experience, but more study and cooperation are required to realize its full potential.
Bezpieczeństwo podczas wymiany pasażerów w tramwajach
Authors: Ciępka Piotr , Śleziak Bogusław , Mandzij Tadeusz
Published: March 2024

Safety during exchange of passengers in trams

Based on three real–life accidents the impact of tram platform design on the safety of passengers during their exchange is discussed. In one of the examples a tram stop which did not meet the public use requirements despite having been built following applicable building regulations is described. On this stop the tram driver was not able to observe the entire side of the tram cars and passenger exchange taking place due to the radius of the curve on which the stop was placed. The other two cases illustrate events which happened after the height of the platforms was increased relative to the track level in order to adapt them to new types of tram cars while the older ones were still being used. On these stops the lower edge of doors of the new low-floor cars was close to the edge of the platform while in the case of the older types of the cars the distance between these edges threatened the safety of boarding or disembarking passengers.
Na afrykańskich i amerykańskich szlakach – vie romancée Aleksandra Marka Jawornickiego
Authors: Karolewska Henryka
Published: March 2024

On African and American Routes – Vie Romancee of Aleksander Marek Jawornicki

The aim of the article is to present, based on a few materials from the Polish and Polish American press from the end of the 19th century, the figure of a lawyer, journalist and traveler who is now forgotten. Aleksander Marek Jawornicki, born in 1847 in Radom, graduated from law studies, but worked in the profession for a short time. From 1874, he collaborated with, among others, with the “Kaliszanin” daily, publishing novels, pictures, humorous sketches, and reviews. In 1887, he took part in a research trip to West Africa, led by Leopold Janikowski. After his return, he published letters, sketches, short stories and novels based on his impressions from the expedition in the Polish press, and in 1892 he was also the editor of “Kaliszanin”. In 1896 he left for America and settled in Chicago. He was the editor of the Polish diaspora “Katolik”, later ran a pharmacy in Milwaukee, was a doctor in Michigan and a priest of the Polish Catholic Church in Chicago. He died there in 1900.
Kościół parafialny w Kokaninie w świetle spisów i wizytacji z przełomu XVIII i XIX stulecia
Authors: Mikołajczyk Marcin
Published: March 2024

The Parish Church in Kokanin in the Light of Censuses and Visitations at the Turn of 18th and 19th Centuries

The aim of the article is to present materials related to the history of the parish church in Kokanin, located near Kalisz. The materials are located in the Diocesan Archives in Włocławek and have never been published before. The presented documents come from 1790 and 1801 and present the financial condition of the parish at the turn of the 18th and 19th centuries.
k-Fractional Ostrowski Type Inequalities via (s, r)−Convex
Authors:   Department of Mathematics, Shah Abdul Latif University Khairpur, Pakistan, HASSAN ALI , KHAN ASIF R. ,   Department of Mathematics, University of Karachi, Pakistan
Published: March 2024

We introduce the generalized class named it the class of (s,r)−convex in mixed kind, this class includes s−convex in 1st and 2nd kind, P−convex, quasi convex and the class of ordinary convex. Also, we state the generalization of the classical Ostrowski inequality via k−fractional integrals, which is obtained for functions whose first derivative in absolute values is (s,r)−convex in mixed kind. Moreover, we establish some Ostrowski type inequalities via k−fractional integrals and their particular cases for the class of functions whose absolute values at certain powers of derivatives are (s,r)−convex in mixed kind by using different techniques including Hölder’s inequality and power mean inequality. Also, various established results would be captured as special cases. Moreover, some applications in terms of special means are given.
Bi-Periodic Hyper-Fibonacci Numbers
Authors:   Faculty of Mathematics, RECITS Laboratory, Algeria, BELAGGOUN NASSIMA , BELBACHIR HACÈNE ,   Faculty of Mathematics, RECITS Laboratory, Algeria,   CERIST: Research Center on Scientific and Technical Information 05, Algeria
Published: March 2024

In the present paper, we introduce and study a new generalization of hyper-Fibonacci numbers, called the bi-periodic hyper-Fibonacci numbers. Furthermore, we give a combinatorial interpretation using the weighted tilings approach and prove several identities relating these numbers. Moreover, we derive their generating function and new identities for the classical hyper-Fibonacci numbers.
On the Zeros of Apolar Polynomials
Authors:   Department of Mathematics, University of Kashmir, India, NAZIR ISHFAQ , MIR MOHAMMAD IBRAHIM ,   Department of Mathematics, University of Kashmir, India, WANI D IRFAN AHMAD ,   Department of Mathematics, University of Kashmir, India
Published: March 2024

The classical notion of apolarity is defined for two complex polynomials of same degree. The main property of two apolar polynomials, f(z) and g(z) was given by Grace’s theorem which states that “every circular domain containing all the zeros of f(z) contains at least one zero of g(z) and vice-versa”. A. Aziz [1] dropped the condition that f(z) and g(z) are of the same degree in case the circular domain is a disk. In this paper, we extend the result of A. Aziz to every kind of circular domain and hence an extension of Grace’s theorem for two arbitrary polynomials is proved. This also allows us to generalise the results of Walsh, Szego, Takagi, Aziz and several other results about apolar polynomials.
Indonesia Space Program : Future Soft Power
Authors: Primbani Murdi , Hermawan Eman
Published: March 2024

This paper discusses Indonesia's space / aerospace industry program as the nation's future Soft Power. The term 'soft power', coined by Joseph S. Nye of Harvard University in the United States, is the ability of a country to influence another country not through coercive means but through attractiveness or reputation. This research uses a literature research approach, which is a method by collecting data by understanding and studying theories from various literature related to research There are four stages of literature study in research. Space, or simply space, is the expanse that exists beyond the Earth and between celestial bodies. Space isn't completely empty it's a hard vacuum containing low particle densities, especially hydrogen and helium plasma, as well as electromagnetic radiation, magnetic fields, neutrinos, dust, and cosmic rays. Recent developments show that in the future, not only professional astronauts can go into space but also all citizens of the world can afford to pay.
A Simple Maneuver to Facilitate Delivery in Shoulder Dystocia
Authors: Kınay Tuğba , Karadeniz R. Sinan , Ustun Yaprak
Published: March 2024

Shoulder dystocia is an unpredictable complication of vaginal delivery and it could lead serious adverse maternal and neonatal outcomes. Prompt intervention and appropriate management of this obstetric emergency is essential to reduce the risk of adverse outcome. The maneuvers that had various advantages and disadvantages to alleviate shoulder dystocia have been described previously. In this report, we defined a new, easy to perform and noninvasive maneuver which could be used to relieve shoulder dystocia. This maneuver was successfully implemented in two nulliparous and two multiparous women who had experienced shoulder dystocia during vaginal delivery. After the diagnosis of shoulder dystocia and unsuccessful McRoberts and suprapubic pressure maneuver, the gentle upward traction on the fetal head and neck was performed in the lithotomy position. The posterior shoulder slipped forward in the sacral hollow and brought closer to the introitus with this maneuver. Thus, the anterior and posterior shoulders were no longer in the same antero-posterior plane of the pelvis. Then the gentle downward traction on the fetal head was applied until the anterior shoulder protruded through the perineum and the impacted anterior shoulder dislodged from behind the symphysis pubis. No other maneuver was needed for the completion of the delivery in these four cases, and no maternal or neonatal complication was observed. In conclusion, the presented maneuver is an easy and noninvasive maneuver. It could be easily learned with simulation training and used in the management of shoulder dystocia.
Pengaruh Kualitas Kebijakan Terhadap Penanaman Modal Asing Langsung pada Negara ASEAN
Authors: Nugraha Pazri
Published: March 2024

Modal investasi merupakan sumber keuangan yang penting bagi dunia usaha dan sektor perekonomian masyarakat untuk berinvestasi, mengkonsumsi dan mengembangkan perekonomian. Penanaman Modal Asing (Foreign Direct Investment) merupakan salah satu jenis pembiayaan negara yang disambut baik oleh pemerintah selain sumber dalam negeri. tren peningkatan Foreign Direct Investment (FDI) di negara-negara ASEAN dari tahun ke tahun. Peningkatan ini menunjukkan bahwa investasi asing semakin mengalir ke wilayah ASEAN seiring berjalannya waktu. Penelitian ini mengunakan data sekunder yang berasan dari 11 negaraASEAN dalam rentang waktu 2009 - 2020. Variable dependen dalam penelitian ini yaitu Foreign Direct Investment (FDI), kemudian untuk variable independen dalam penelitian ini yaitu, Populasi penduduk, Upah, Kualitas regulasi, Stabilitas politik dan Inflasi. Hasil penenlitian menunjukan populasi berpengaruh secara signifikan terhadap FDI di negara-negara ASEAN, Kualitas regulasi pemerintah berpengaruh secara signifikan dan positif terhadap FDI di negara-negara ASEAN terakhir Stabilitas politik berpengaruh secara signifikan dan positif terhadap FDI di negara-negara ASEAN.
Karakteristik Ekonomi Petani di Desa Sempu Kabupaten Kediri
Authors: Ayuni Ita Kurata
Published: March 2024

Pertanian merupakan mata pencaharian utama bagi penduduk Sempu. Desa Sempu berada di daerah yang rentan terhadap bencana vulkanik Kelud yang dapat berbahaya bagi sektor pertanian. Penelitian ini bertujuan untuk Mengidentifikasi Karakteristik Ekonomi Petani di daerah rawan bencana gunung berapi Kelud. Metode penelitian yang digunakan adalah Data primer yang didapatkan dari hasil survei dengan pengisian kuesioner terhadap petani di Desa Sempu untuk memperoleh data karakteristik ekonomi. Hasilnya dapat digunakan untuk mengevaluasi strategi dan kebijakan terkait pengurangan risiko bencana. Pengumpulan data menggunakan metode survei dengan 100 petani. Sebagian besar petani di Desa Sempu menerapkan diversifikasi pertanian sehingga mereka memiliki pendapatan yang relatif besar. Namun, petani masih memiliki lahan pertanian yang terbatas, kepemilikan tanah tidak bersifat pribadi, dan sumber modal berasal dari pinjaman.
The Correlation between the Awareness of the Dangers in Smartphone Radiation and Sleep Quality among High School Students in Thailand
Authors:   Trinity International School (TRIS), Bangkok, Thailand, Jitvootthikai Thanapat , Jitvootthikai Cherfa ,   Trinity International School (TRIS), Bangkok, Thailand
Published: March 2024

Despite smartphones’ critical benefits in several aspects of living in this generation, their emissions of radiation exert profound effects on the physical health of the affected individuals, including heightened risks of cancer as well as increased fibroblast activity of the skin. The aim of this study endeavors to determine the correlation between awareness of the dangers in utilizing smartphones before bed and sleep quality among high school students, to raise consciousness of the perils of smartphone radiation, and to observe sleep qualities among high school students. Through previous research, it was hypothesized that awareness of the dangers in smartphone radiation would negatively impact the sleep quality of the participants due to the negative ramifications of the radiation. To verify whether this also implies an impact on the Thai population, data were collected using a cross-sectional method with random samples of both Thai and international high school students. The information was later analyzed via Statistical Product and Service Solutions (SPSS). The results indicate a robust correlation between dangers in smartphone’s radiation and sleep quality (p = 0.451**), grade and sleep quality (p = 0.003*), and age and sleep quality (p = 0.002*). Moreover, a strong correlation between grade and sleep quality, as well as age and sleep quality, can be inferred that grade and age correlate with the amount of stress within individuals, having a negative effect on individuals’ sleep quality. Ultimately, this research not only analyzes the correlation in the findings but also aims to raise awareness of potential hazards in smartphone radiation among high school students to enhance their sleep quality.
The Influence of Sustainability Disclosure on Financial Performance: A Study of Indonesian Firms
Authors:   School of Business and Management ITB, Indonesia., Rachmat Lutrika Mufti
Published: March 2024

This study examines the correlation between the disclosure of sustainability measures and the financial success of companies in Indonesia. The increasing importance of sustainability disclosure, which includes environmental, social, and governance factors, for firms to demonstrate their dedication to sustainable practices, has generated significant debate on its influence on financial results. This study investigates the impact of sustainability disclosures on the financial performance of companies in Indonesia, thus adding to the existing body of knowledge on this topic. The study utilizes a mixed-method approach, incorporating qualitative content analysis of data extracted from annual reports, as well as quantitative analysis derived from financial statements of publicly traded corporations. The sample consists of companies from three major industry sectors, each demonstrating different levels of quality in disclosing their sustainability practices. Accounting-based indicators like return on assets (ROA) and return on equity (ROE) are used to evaluate financial performance. The findings demonstrate a direct and favorable relationship between the caliber of sustainability disclosures and financial performance, specifically in sectors that are highly responsive to environmental concerns. Companies that have more comprehensive and transparent sustainability reporting processes in these industries generally achieve better performance compared to those with less comprehensive reporting. These conclusions have substantial ramifications for firms, investors, and policymakers. Enhancing sustainability disclosure can enhance a company’s financial performance and act as a significant factor for investment choices, providing information about a company’s dedication to sustainability and related risks. Policymakers can utilize these observations to support the implementation of improved sustainability reporting regulations, thereby fostering sustainable economic growth in Indonesia. Ultimately, the research confirms that Indonesian companies who provide detailed and reliable information on their sustainability efforts have a positive correlation with their financial performance. This emphasizes the significance of improving these practices to achieve both economic prosperity and sustainable development objectives.
Two-Nation Theory and division of the Indian Subcontinent: analysing the idealist and revisionist perspectives
Authors: Khan Hafiz Muhammad Abdul Samad , Khan Sarosh , Mobashir Syeda Hira
Published: March 2024

Two-Nation Theory, long regarded as the linchpin of the partition of the Indian Subcontinent in 1947, has come under scrutiny by revisionist scholars who seek to challenge and question the prevailing idealism surrounding this historical division. Revisionist perspectives offer a critical analysis of the Two-Nation Theory by contesting its oversimplified portrayal of Muslims in the Subcontinent. These scholars assert that the theory, which framed the partition because of irreconcilable religious differences, neglects the intricate tapestry of cultural, linguistic, and regional identities among Muslims. Moreover, revisionists delve into the multifaceted causes of partition, asserting that it cannot be solely attributed to religious disparities. They emphasise the role of political manoeuvring, economic inequalities, power dynamics, and the shortcomings of leadership in shaping this historical event. Revisionist arguments also suggest that political leaders, such as Muhammad Ali Jinnah and the All-India Muslim League, may have strategically employed the Two-Nation Theory to secure advantages during negotiations with the British colonial administration. This challenges the prevailing notion that the demand for a separate Muslim state primarily reflects religious sentiment. This research attempts to contemplate the revisionist perspectives on the Two-Nation Theory, which ultimately led to the division of the Subcontinent.
Evaluation of water genotoxicity using comet assay in two freshwater fish species, Wallago attu and Ompok bimaculatus in Kabul River, Pakistan
Authors: Siraj Muhammad , Murtaza Bibi Nazia , Sardar Amina , Muntaha Sidra Tul , Waheed Aisha , Khan Iqra Gul , Ali Pir Asmat , Chivers Douglas
Published: March 2024

The investigation determines the pollution status of river Kabul and its effects on the DNA of Wallago attu and Ompok bimaculatus. River Kabul gets pollutants from Amanghar industries and sewages from Mardan, Nowshera and Peshawar. Water and fish samples are taken to study heavy metals and physical parameters. The overall sequence of physical parameters in water samples was TDS>TSS>EC>TA>Cl>Na>pH>K, and that of heavy metals was Zn>Cr>Mn> Fe>Cu>Pb>Ni>Cd. The studied parameters in all the water samples except TSS are within the proposed limits of national environmental quality standards. The overall trend of analysed water samples was C>B>A. The study determines the effects of water pollution on the DNA of Ompok bimaculatus and Wallago attu tissues. Therefore, degrees of DNA damage such as TCS and comet class are studied in gills, liver, muscles, and intestines of Wallago attu and Ompok bimaculatus. The trend of DNA damage in examined tissues was intestine>skin>liver>gills>muscle, and in studied fish species, it was Ompok bimaculatus>Wallago attu. More significant DNA damage was observed in the intestine and smaller in the muscle. More DNA damage was found in Ompok bimaculatus and less in Wallago attu. The investigation recommended detoxifying the effluents and sewages before discharging them in River Kabul.
Heart and Lung Dysfunction Prevention Through Rehabilitation and Physical Therapy Education: A Comprehensive Overview
Authors:   Exercise Physiologist Enjoy Rehab PT PC Woodbury, NY, USA, Baldania Shraddha , Baladaniya Maheshkumar ,   Physical Therapist Neighborhood Physical therapy PC Brooklyn, NY, USA
Published: March 2024

Cardiovascular and respiratory diseases are among the leading causes of morbidity and mortality worldwide. Physical therapists (PTs) have a unique opportunity to prevent and manage these conditions by providing patient education on cardiopulmonary health. This white paper discusses the essential role of patient education in reducing the risk and impact of heart and lung dysfunction and highlights the toolkit that PTs possess to deliver effective and evidence-based education. It also provides practical strategies and examples for PTs to educate individuals on topics such as exercise, smoking cessation, nutrition, stress management, and self-monitoring. By empowering patients with knowledge and skills, PTs can help them achieve optimal cardiopulmonary health and quality of life.
Effects of Water Hyacinth (Eichhnornia Crassipe) on Carbon and Phosphorus Mineralization in Wetland Soils
Authors:   Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University Awka, Nigeria, Otobo Grace , Nkemjika Aduaka Cecilia , Fegor Isoje Endurance ,   Department of Chemistry, Delta State University of Science and Technology, Ozoro, Nigeria, Chukwuna Vinna Daniel
Published: March 2024

This work investigated the kinetics of Carbon and Phosphorus Mineralization in Wetland Soils amended with water Hyacinth (Eichhnornia Crassipe). The work studied the effects of water hyacinth also known as Eichhornia Crassipe on Carbon and Phosphorus Mineralization in Delta Wetland soil. The kinetics of Carbon and Phosphorus Mineralization was studied using Pseudo Second Order Equation. The Respiration Assay of the organic matter (Water Hyacinth) incorporated leads to emission of carbon in the form of carbon (iv) oxide and greater degree of microbial activities than those occurring in the control Soils after initial stage of incubation. Reaction Rates decreases with time in the amended Soil. In all the Soil samples, initial rapid phase of mineralization was clearly observed. Phosphorus Mineralization increased gradually with time in the amended soil as a result of high degree of organic matter and the pH of the soils.
Analisis Pelaksanaan dan Penatausahaan Keuangan pada Sekretariat Daerah Kabupaten Kulon Progo Berdasarkan Teori Governabilitas dan Govermentalitas
Authors: Wahyono Cahyo , Nugroho Ridwan , Huraq Florianus , Muhammad Adji Suradji
Published: March 2024

Pengelolaan keuangan daerah diatur dalam Peraturan Pemerintah Nomor 12 Tahun 2019 Tentang Pengelolaan Keuangan Daerah. Peraturan Pemerintah (PP) tersebut diikuti petunjuk teknis pelaksanaan dengan dikeluarkannya Peraturan Menteri Dalam Negeri (Permendagri) Nomor 77 Tahun 2020 tentang Pedoman Teknis Pengelolaan Keuangan Daerah. Terdapat ketidaksesuaian dalam pelaksanaan dan penatausahaan keuangan Sekretariat Daerah Kabupaten Kulon Progo. Penelitian ini bertujuan mengetahui ketidaksesuaian dengan Permendagri Nomor 77 Tahun 2020 dilihat dari perspektif Teori Governabilitas dan implikasinya dilihat dari Teori Govermentalitas. Metode analisis yang digunakan adalah membandingkan pelaksanaan dan penatausahaan keuangan Sekretariat Daerah dengan Permendagri Nomor 77 Tahun 2020. Dalam Perspektif Governabilitas melakukan tindakan ketidaksesuain merupakan otoritas dan kapasitas Pemerintah Kabupaten Kulon Progo yang diambil dengan penuh pertimbangan guna meningkatkan kinerja pelaksanaan dan penatausahaan keuangan daerah. Dalam perspektif Govermentalitas Kementerian Dalam Negeri menetapkan sistem pengelolaan keuangan yang menjadi wujud terkendali dan terkontrolnya seluruh proses pengelolaan keuangan daerahseluruh provinsi dan kabupaten/kota di Indonesia.
Treatment Options for High Cardiometabolic Risk Patients with Atherosclerosis
Authors: Gour Tanay
Published: March 2024

In 2020, coronary artery disease (CAD) affected over 20 million people and resulted in 382,820 deaths in the United States. Heart disease such as CAD and its precursor atherosclerosis have severe consequences such as limiting the amount of blood flow and reducing the flow of vital elements like oxygen to vital tissues and organs like the heart. Elderly adults, obese patients, patients with diabetes, and those with a genetic predisposition of increased Low-Density Lipids (LDLs), are at higher risk of developing atherosclerosis. This paper examines treatment options for atherosclerosis in people with high cardiometabolic risk and discusses their efficacy as well as their associated risks and benefits. First-line therapy includes medication such as statins, ACE Inhibitors, or diuretics along with appropriate lifestyle adjustments. If unsuccessful, second-line interventions offer increased risk reduction in patients with established coronary vascular disease and reduce the probability of recurrence of an acute cardiac event. This calls for the use of medication with higher risks such as beta blockers and anti-thrombotics and even surgical procedures such as bypass and angioplasties. Regardless of the patient’s condition, the first recommendation for preventing and managing atherosclerosis is lifestyle adjustment. Medications offer benefits but with varying levels of side effects. Thus, it is important to look at the specific conditions of each patient to find the most suitable medication. This paper looked at the existing magnitude of treatments for atherosclerosis and summarised which ones are best for patients with different conditions that put them at high risk for developing atherosclerosis.
Killing to Cling to Power? The Dilemmas of Israeli Prime Minister
Authors: Braimah Awaisu
Published: March 2024

Hamas's strategic surprise attack on Israel on October 7, 2023, is not only a military and intelligence failure on the part of Israel, but it also casts doubt on the capacity of the Israeli Prime Minister to provide the security needs of Israelis. What this paper does is explore the complexities and dilemmas of Israel’s war on Gaza despite domestic pressure to halt the Gaza war to enable the release of hostages, the call on the coalition government to account for the needless deaths of Israelis on the fateful October 7, 2023 attack and the growing pressure abroad to respect humanitarian law of war in Gaza. The war nevertheless continues unabated while Hamas is ducking for cover with the multiracial captives. The multilevel demands on the Israeli PM and his right-wing coalition have ramifications on the regime’s legitimacy, a bleak future for the two-state solution, and the general implication of the war on global politics. This paper utilised the Diversionary Theory of War to explain the Israel-Hamas war in Gaza. The paper argues that Hamas attacked Israel to thwart the normalisation process between Israel and Saudi Arabia, while the Israeli prime minister is using the Gaza war as an alibi to boost his reelection bid and to divert the attention of Israelis from the toxic domestic politics to cling to power.
ABORDAGENS DIAGNÓSTICAS E TERAPÊUTICAS DA SÍNDROME DE CUSHING: UMA REVISÃO BIBLIOGRÁFICA DE LITERATURA
Authors: Mainardo Rodrigues Bezerra Lucas , Martins Oliveira Taisnara , De Arruda Frazão Mariana , Calixtrato Pesconi Beatriz , Inácio Aragão Igor , De Araújo Marques Alcântara João Victor , Moreira Menezes Éric , Freire de Morais Rainally Sabrina , Rodrigues Baldoino Lorenna Kellyne
Published: March 2024

A Síndrome de Cushing é uma condição endócrina rara e complexa, caracterizada pelo aumento crônico dos níveis de cortisol no organismo, que pode resultar em uma variedade de sintomas físicos e metabólicos significativos. Objetivo: Este estudo visa explorar avanços e descobertas recentes no diagnóstico e tratamento da Síndrome de Cushing. Métodos: Realizou-se uma revisão bibliográfica dos últimos 15 anos, incluindo estudos originais e revisões, com critérios de inclusão específicos para abordar sobre a Síndrome de Cushing. Resultados e Discussão: A etiologia da Síndrome de Cushing é multifacetada, refletindo a complexidade dessa condição endócrina. Os métodos diagnósticos padrão para a Síndrome de Cushing incluem testes laboratoriais para avaliar os níveis de cortisol e ACTH no sangue, urina e saliva, bem como exames de imagem para localizar a fonte da hiperprodução hormonal. As opções terapêuticas para a Síndrome de Cushing, conforme evidenciado na revisão dos estudos atuais, apresentam uma ampla gama de abordagens, incluindo cirurgia, terapia medicamentosa e radioterapia Conclusão: A revisão enfatiza a importância da educação e conscientização sobre a Síndrome de Cushing entre profissionais de saúde, pacientes e cuidadores, a fim de facilitar o diagnóstico precoce, o acesso ao tratamento adequado e o apoio emocional necessário.