bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation of salivary neopterin and plasma fibrinogen levels in patients with chronic periodontitis and/or type 2 diabetes mellitus
Authors: Fenol Angel , Swetha V.R. , Krishnan Sajitha , Perayil Jayachandran , Vyloppillil Rajesh , Bhaskar Anuradha , Shereef Mohammed , Balakrishnan Biju , Puzhankara Lakshmi
Published: August 2017

Neopterin is a novel predictor for coronary events especially in diabetic patients and also an indicator for the effectiveness of the periodontal treatment. In this study, we assessed whether salivary neopterin can be used as a potential biomarker in evaluating the risk of cardiovascular disease in type 2 diabetic patients with chronic periodontitis. Forty subjects between 25 and 75 years of age and who matched the criteria were selected and divided into four groups. Their periodontal status was evaluated. Stimulated whole saliva and blood were collected for analysis of salivary neopterin and fibrinogen and HbA1c levels, respectively. Nonsurgical periodontal therapy was carried out. Patients were recalled after 3 months, and the same procedure was repeated. A reduction in all the parameters was seen after treatment in all the four groups. Salivary neopterin levels showed significant difference (p<0.001) in the values between the study groups and the control group before treatment. After 3 months of treatment, salivary neopterin levels showed a statistical significant reduction (p<0.001) in all the study groups. Neopterin could serve as an effective tool to assess the inflammatory process related to periodontitis and diabetes mellitus and also predict future cardiovascular events in diabetic patients.
The role of séméiotique in François Delsarte’s aesthetics
Authors: Fischer Iris Smith
Published: August 2017

This article introduces the aesthetic theory of François Delsarte (1811–1870) and his conception of semiotics. Delsarte created his “applied aesthetics” as a modern scientific method for artists, particularly performers, to investigate the nature of human being. Delsarte’s approach to performance involved the actor in observing human behavior, interpreting it through categories of voice, gesture, and language, and rendering it in an expansive display of types. Delsarte’s applied aesthetics involves the performer’s attention to signs and sign action, a study he called séméiotique. We see Delsarte’s program for inquiry into truth in what I call the actor’s task, which develops his or her human being through observation, analysis, and creation. This was Delsarte’s “orthopedic machine for correcting crippled intellects” – the crippled intellects being those intellectuals and conservatory teachers whose ideas on aesthetics he found to be neither systematic nor attuned to God’s reason. While it is well known in theatre and dance scholarship that Delsarte’s ideas and methods advanced the training of actors, dancers, and orators, particularly in the United States, my paper instead introduces him as a voice in nineteenth-century thinking on signs and semiosis. Delsarte’s aesthetics are firmly based in Thomist assumptions about a triune god whose nature is reflected imperfectly in man. Yet it is striking that Delsarte characterizes the sign relation as mediated in a modern sense, prior to Charles Peirce’s development of his own triadic sign relation, and semiotics as a modern method of scientific inquiry.
The gap between instruction (plan) and situated action: A challenge to semiotics?
Authors: Roth Wolff-Michael
Published: August 2017

In this study, I describe a potential challenge to semiotics, which exists in the fact that no interpretation of an instruction (text) can get us closer to doing what the instructional text describes. I provide a praxeological description of a situation in a software development firm where the instructions (rules) for a particular type of meeting are inscribed on the whiteboard in front of which the meetings were held. I discuss the gap between instructions and the behavior they describe and the moral order of praxis that is not inscribed in instructions.
“What makes a reasoning sound” is the proof of its truth: A reconstruction of Peirce’s semiotics as epistemic logic, and why he did not complete his realistic revolution
Authors: Nesher Dan
Published: August 2017

Charles S. Peirce attempted to develop his semiotic theory of cognitive signs interpretation, which are originated in our basic perceptual operations that quasi-prove the truth of perceptual judgment representing reality. The essential problem was to explain how, by a cognitive interpretation of the sequence of perceptual signs, we can represent external physical reality and reflectively represent our cognitive mind’s operations of signs. With his phaneroscopy introspection, Peirce shows how, without going outside our cognitions, we can represent external reality. Hence Peirce can avoid the Berkeleyian, Humean, and Kantian phenomenologies, as well as the modern analytic philosophy and hermeneutic phenomenology. Peirce showed that with the trio of semiotic interpretation – abductive logic of discovery of hypotheses, deductive logic of necessary inference, and inductive logic of evaluation – we can reach a complete proof of the true representation of reality. This semiotic logic of reasoning is the epistemic logic representing human confrontation in reality, with which we can achieve knowledge and conduct our behavior. However, Peirce did not complete his realistic revolution to eliminate previously accepted nominalistic and idealistic epistemologies of formal logic and pure mathematics. Here, I inquire why Peirce did not complete his historical realist epistemological revolution and following that inquiry I attempt to reconstruct it.
Iconic silence: A semiotic paradox or a semiotic paragon?
Authors: Ephratt Michal
Published: August 2017

For a sign to be a sign it must bond an object (quality), a signifier, and the idea to which it gives rise (CP 1.339). The paper focuses on the iconicity of silence as a hypoiconic signifier, exploring the semiotics of silence in light of the notions and studies of iconicity. Fascinating parallelisms hold between iconicity and silence. These raise many challenges to the study of each separately, let alone dealing with them jointly. Some icons and some silences are qualities in the real world, others are semiotic forms (signifiers) standing for or denoting objects. Simple, intuitive qualities of iconicity and of silence are naturally grasped and shared from antiquity to the present by cultures and peoples. The paper employs Peirce’s initial basic trichotomy of iconic classes as well as his later hierarchies for studying the iconic stance of silence as a hypoiconic signifier (Secondness). Analyzing and illustrating the possible complexities between forms (a silent signifier), contents, their relations and their interpretations, group hypoiconic silences into silence as an image, silence as a diagram, and silence as a metaphor.
The lens of firstness: Shamanic/Aboriginal culture as cosmos-sign
Authors: Bonta Steven
Published: August 2017

Having identified previously (Bonta 2015) the Peircean Category Firstness as the semiotic basis (or cultural Prime Symbol) for Australian Aboriginal culture, this paper examines the “lens” of Firstness as it is manifest in a variety of aboriginal (or “Shamanic”) cultures worldwide. By studying the semiotic contours of religion, language, social organization, and art, we find systemic prioritization of Firstness in its various manifestations, across a wide range of aboriginal cultures from Australia to the Indian Subcontinent to aboriginal Siberia and the New World. Shamanic culture, despite its ethnic and geographic variety, may therefore be represented as a semiotic type – and, in addition, one that, in its pristine form, is nearly extinct.
Stylistique et sémiotique tensive : Convergences et divergences
Authors: Dorra Raul , Rodriguez Blanca Alberta
Published: August 2017

À partir de De l’imperfection et de
Sémiotique des passions (1991), la sémiotique a opéré un tournant vers la reconnaissance du sensible comme fondement de la signification. Suivant cette voie, la sémiotique tensive s’est développée en enrichissant la théorie générale. De leur côté, en étudiant il y a plus d’un siècle la qualité expressive de l’œuvre littéraire, les philologues Amado Alonso et Dámaso Alonso – représentants de la stylistique espagnole – ont posé tôt pour la tradition hispanique le problème de l’affectivité dans le langage. Leurs travaux reprennent l’interprétation par l’école allemande de la stylistique de Bally. Notre article propose de faire un contrepoint entre la perspective de la sémiotique tensive et celle de la stylistique espagnole. Cette entreprise exige de reconnaître les divergences épistémologiques, mais surtout – suivant notre propos – de suggérer des points de rencontre et des visions complémentaires. Tandis que pour la sémiotique tensive l’affectivité est prise en charge par le plan du contenu, pour la stylistique elle se manifeste dans ce qui pour Dámaso Alonso serait – en élargissant la définition de Saussure – le signifiant à proprement parler: l’image acoustique réalisée dans sa matérialité sonore. De sorte que, dans l’échange entre ces deux perspectives disciplinaires, les trouvailles méthodologiques de l’une pourraient être utiles à l’autre, dans la mesure où toutes deux ont en partage l’intérêt pour la manière dont l’affectivité s’exprime.
Determining knowledge of the nursing students about biochemistry laboratory samples
Authors: Yılmaz Tamer , Yılmaz Ümran Dal
Published: August 2017

Objective

The aim of the study is to determine knowledge of nursing students about taking and transferring of bio-chemical laboratory samples.

Methods

The study is descriptive and was conducted during the spring semester of the 2016–2017 academic year and 118 volunteer final year nursing department students were included in the study. As a data collection tool, a questionnaire which was prepared by the researcher.

Results

Eleven percentage of the final year students of the nursing department answered the information that should be in the laboratory sample request document and 83.9% responded correctly to the optimal blood-letting time for the biochemical analysis. It was determined that 52.5% of the students correctly know whether the sitting, lying or on-foot blood-letting positions affect the blood values or not, and 45.8% know the reason why blood-letting is performed in sitting or lying positions. 57.1% of the students correctly identified the medium urine sample and 14.3% correctly understood the 24-h urine collection practices.

Conclusion

It was determined that the students lacked information on the taking, storage and transfer of the biochemical laboratory samples and it was detected that the missing information was provided in the curriculum.
Visual Receptive Field Heterogeneity and Functional Connectivity of Adjacent Neurons in Primate Frontoparietal Association Cortices
Authors: Viswanathan Pooja , Nieder Andreas
Published: August 2017

The basic organization principles of the primary visual cortex (V1) are commonly assumed to also hold in the association cortex such that neurons within a cortical column share functional connectivity patterns and represent the same region of the visual field. We mapped the visual receptive fields (RFs) of neurons recorded at the same electrode in the ventral intraparietal area (VIP) and the lateral prefrontal cortex (PFC) of rhesus monkeys. We report that the spatial characteristics of visual RFs between adjacent neurons differed considerably, with increasing heterogeneity from VIP to PFC. In addition to RF incongruences, we found differential functional connectivity between putative inhibitory interneurons and pyramidal cells in PFC and VIP. These findings suggest that local RF topography vanishes with hierarchical distance from visual cortical input and argue for increasingly modified functional microcircuits in noncanonical association cortices that contrast V1.

SIGNIFICANCE STATEMENTOur visual field is thought to be represented faithfully by the early visual brain areas; all the information from a certain region of the visual field is conveyed to neurons situated close together within a functionally defined cortical column. We examined this principle in the association areas, PFC, and ventral intraparietal area of rhesus monkeys and found that adjacent neurons represent markedly different areas of the visual field. This is the first demonstration of such noncanonical organization of these brain areas.
Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex
Authors: Meunier Claire , Wang Nan , Yi Chenju , Dallerac Glenn , Ezan Pascal , Koulakoff Annette , Leybaert Luc , Giaume Christian
Published: August 2017

Astrocytes interact dynamically with neurons by modifying synaptic activity and plasticity. This interplay occurs through a process named gliotransmission, meaning that neuroactive molecules are released by astrocytes. Acting as a gliotransmitter, D-serine, a co-agonist of the NMDA receptor at the glycine-binding site, can be released by astrocytes in a calcium [Ca2+]i-dependent manner. A typical feature of astrocytes is their high expression level of connexin43 (Cx43), a protein forming gap junction channels and hemichannels associated with dynamic neuroglial interactions. Pharmacological and genetic inhibition of Cx43 hemichannel activity reduced the amplitude of NMDA EPSCs in mouse layer 5 prefrontal cortex pyramidal neurons without affecting AMPA EPSC currents. This reduction of NMDA EPSCs was rescued by addition of D-serine in the extracellular medium. LTP of NMDA and AMPA EPSCs after high-frequency stimulation was reduced by prior inhibition of Cx43 hemichannel activity. Inactivation of D-serine synthesis within the astroglial network resulted in the reduction of NMDA EPSCs, which was rescued by adding extracellular D-serine. We showed that the activity of Cx43 hemichannels recorded in cultured astrocytes was [Ca2+]Idependent. Accordingly, in acute cortical slices, clamping [Ca2+]iat a low level in astroglial network resulted in an inhibition of NMDA EPSC potentiation that was rescued by adding extracellular D-serine. This work demonstrates that astroglial Cx43 hemichannel activity is associated with D-serine release. This process, occurring by direct permeation of D-serine through hemichannels or indirectly by Ca2+entry and activation of other [Ca2+]i-dependent mechanisms results in the modulation of synaptic activity and plasticity.

SIGNIFICANCE STATEMENTWe recorded neuronal glutamatergic (NMDA and AMPA) responses in prefrontal cortex (PFC) neurons and used pharmacological and genetic interventions to block connexin-mediated hemichannel activity specifically in a glial cell population. For the first time in astrocytes, we demonstrated that hemichannel activity depends on the intracellular calcium concentration and is associated with D-serine release. Blocking hemichannel activity reduced the LTP of these excitatory synaptic currents triggered by high-frequency stimulation. These observations may be particularly relevant in the PFC, where D-serine and its converting enzyme are highly expressed.
Opposite Synaptic Alterations at the Neuromuscular Junction in an ALS Mouse Model: When Motor Units Matter
Authors: Tremblay Elsa , Martineau Éric , Robitaille Richard
Published: August 2017

Denervation of the neuromuscular junction (NMJ) precedes the loss of motor neurons (MNs) in amyotrophic lateral sclerosis (ALS). ALS is characterized by a motor unit (MU)-dependent vulnerability where MNs with fast-fatigable (FF) characteristics are lost first, followed by fast fatigue-resistant (FR) and slow (S) MNs. However, changes in NMJ properties as a function of MU types remain debated. We hypothesized that NMJ synaptic functions would be altered precociously in an MU-specific manner, before structural alterations of the NMJ. Synaptic transmission and morphological changes of NMJs have been explored in two nerve–muscle preparations of maleSOD1G37Rmice and their wild-type (WT) littermates: the soleus (S and FR MU); and the extensor digitorum longus (FF MU). S, FR, and FF NMJs of WT mice showed distinct synaptic properties from which we build an MU synaptic profile (MUSP) that reports MU-dependent NMJ synaptic properties. At postnatal day 180 (P180), FF and S NMJs of SOD1 already showed, respectively, lower and higher quantal content compared with WT mice, before signs of MN death and before NMJ morphological alterations. Changes persisted in both muscles until preonset (P380), while denervation was frequent in the mutant mouse. MN death was evident at this stage. Additional changes occurred at clinical disease onset (P450) for S and FR MU. As a whole, our results reveal a reversed MUSP in SOD1 mutants and highlight MU-specific synaptic changes occurring in a precise temporal sequence. Importantly, changes in synaptic properties appear to be good predictors of vulnerability to neurodegeneration.

SIGNIFICANCE STATEMENTThe inadequate excitability of motor neurons and their output, the neuromuscular junctions (NMJs), has been considered a key factor in the detrimental outcome of the motor function in amyotrophic lateral sclerosis. However, a conundrum persists at the NMJ whereby persistent but incoherent opposite neurotransmission changes have been reported to take place. This article untangles this conundrum by systematically analyzing the changes in synaptic properties over the course of the disease progression as a function of the motor unit type. This temporal analysis reveals that early synaptic alterations evolve with disease progression but precede NMJ neurodegeneration. These data provide a novel framework of analysis and comparison of synaptic transmission alterations in neurodegenerative disorders.
STIM1 Regulates Somatic Ca2+Signals and Intrinsic Firing Properties of Cerebellar Purkinje Neurons
Authors: Ryu Changhyeon , Jang Dong Cheol , Jung Dayoon , Kim Yong Gyu , Shim Hyun Geun , Ryu Hyun-Hee , Lee Yong-Seok , Linden David J. , Worley Paul F. , Kim Sang Jeong
Published: August 2017

Control of Ca2+flux between the cytosol and intracellular Ca2+stores is essential for maintaining normal cellular function. It has been well established in both neuronal and non-neuronal cells that stromal interaction molecule 1 (STIM1) initiates and regulates refilling Ca2+into the ER. Here, we describe a novel, additional role for STIM1, the regulation of free cytosolic Ca2+, and the consequent control of spike firing in neurons. Among central neurons, cerebellar Purkinje neurons express the highest level of STIM1, and they fire continuously in the absence of stimulation, making somatic Ca2+homeostasis of particular importance. By using Purkinje neuron-specific STIM1 knock-out (STIM1PKO) male mice, we found that the deletion of STIM1 delayed clearance of cytosolic Ca2+in the soma during ongoing neuronal firing. Deletion of STIM1 also reduced the Purkinje neuronal excitability and impaired intrinsic plasticity without affecting long-term synaptic plasticity. In vestibulo-ocular reflex learning, STIM1PKOmale mice showed severe deficits in memory consolidation, whereas they were normal in memory acquisition. Our results suggest that STIM1 is critically involved in the regulation of the neuronal excitability and the intrinsic plasticity of the Purkinje neurons as well as cerebellar memory consolidation.

SIGNIFICANCE STATEMENTStromal interaction molecule 1 (STIM1), which regulates the refilling of ER Ca2+, has been investigated in several systems including the CNS. In addition to a previous study showing that STIM1 regulates dendritic ER Ca2+refilling and mGluR1-mediated synaptic transmission, we provide compelling evidence describing a novel role of STIM1 in spike firing Purkinje neurons. We found that STIM1 regulates cytosolic Ca2+clearance of the soma during spike firing, and the interruption of this cytosolic Ca2+clearing disrupts neuronal excitability and cerebellar memory consolidation. Our results provide new insights into neuronal functions of STIM1 from single neuronal Ca2+dynamics to behavior level.
Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens
Authors: Shoura Massa J , Gabdank Idan , Hansen Loren , Merker Jason , Gotlib Jason , Levene Stephen D , Fire Andrew Z
Published: August 2017

Investigations aimed at defining the 3D configuration of eukaryotic chromosomes have consistently encountered an endogenous population of chromosome-derived circular genomic DNA, referred to as extrachromosomal circular DNA (eccDNA). While the production, distribution, and activities of eccDNAs remain understudied, eccDNA formation from specific regions of the linear genome has profound consequences on the regulatory and coding capabilities for these regions. Here, we define eccDNA distributions in Caenorhabditis elegans and in three human cell types, utilizing a set of DNA topology-dependent approaches for enrichment and characterization. The use of parallel biophysical, enzymatic, and informatic approaches provides a comprehensive profiling of eccDNA robust to isolation and analysis methodology. Results in human and nematode systems provide quantitative analysis of the eccDNA loci at both unique and repetitive regions. Our studies converge on and support a consistent picture, in which endogenous genomic DNA circles are present in normal physiological states, and in which the circles come from both coding and noncoding genomic regions. Prominent among the coding regions generating DNA circles are several genes known to produce a diversity of protein isoforms, with mucin proteins and titin as specific examples.
Rhythmic Behavior Is Controlled by the SRm160 Splicing Factor inDrosophila melanogaster
Authors: Beckwith Esteban J , Hernando Carlos E , Polcowñuk Sofía , Bertolin Agustina P , Mancini Estefania , Ceriani M Fernanda , Yanovsky Marcelo J
Published: August 2017

Animals have evolved neural circuits that allow them to generate adaptive behaviors to their natural environment. Specific neuronal clusters depend on.....

Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day–night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that modulate these rhythms remain largely unexplored. A genome-wide assessment of the alterations of gene expression in a null mutant of the alternative splicing regulator SR-related matrix protein of 160 kDa (SRm160) revealed the extent to which alternative splicing impacts on behavior-related genes. We show that SRm160 affects gene expression in pacemaker neurons of the Drosophila brain to ensure proper oscillations of the molecular clock. A reduced level of SRm160 in adult pacemaker neurons impairs circadian rhythms in locomotor behavior, and this phenotype is caused, at least in part, by a marked reduction in period (per) levels. Moreover, rhythmic accumulation of the neuropeptide PIGMENT DISPERSING FACTOR in the dorsal projections of these neurons is abolished after SRm160 depletion. The lack of rhythmicity in SRm160-downregulated flies is reversed by a fully spliced per construct, but not by an extra copy of the endogenous locus, showing that SRm160 positively regulates per levels in a splicing-dependent manner. Our findings highlight the significant effect of alternative splicing on the nervous system and particularly on brain function in an in vivo model.
„Market Sounding“ nach der Marktmissbrauchsverordnung
Authors: Singhof Bernd
Published: August 2017

Mit Inkrafttreten der EU-Marktmissbrauchsverordnung und ihrer Durchführungsverordnungen wurden im vergangenen Jahr erstmals Rahmenbedingungen für die rechtliche Zulässigkeit sog. Marktsondierungen geschaffen. Die Ansprache von ausgewählten Investoren unmittelbar vor einer geplanten Kapitalmarkttransaktion zur Auslotung ihres Teilnahmeinteresses ist gleichwohl schon lange etablierter Bestandteil (prospektfreier) Wertpapieremissionen. Bislang behalfen sich die begleitenden Banken mit – weitgehend identischen – internen Compliance-Vorgaben, um die Vereinbarkeit der potenziellen Mitteilung von Insiderinformationen mit dem insiderrechtlichen Weitergabeverbot sicherzustellen. Vieles davon ist in das ausführliche Regelwerk eingeflossen. Dennoch bereitet seine Anwendung und dogmatische Einordnung nicht unerhebliche Schwierigkeiten. Der folgende Beitrag soll einen praxisorientierten Überblick über das neue kapitalmarktrechtliche Regime für Marktsondierungen geben und versucht, Lösungen für bestehende Unstimmigkeiten aufzuzeigen.
Der Markt für Mittelstandsanleihen – eine Diagnose
Authors: Schüler Andreas , Aschauer Florian
Published: August 2017

Der Beitrag analysiert den Einfluss von Ausstattungsmerkmalen (Spread, Covenants und Sicherheiten) und Ratings bei Emission auf die Indikatoren des Erfolgs (Platzierungsquote, Rating-Entwicklung und Ausfallrate) sämtlicher bis Ende 2016 emittierter Mittelstandsanleihen differenziert nach Branche und verkündetem Emissionsmotiv. In unserer Untersuchung unterscheiden wir zwischen besicherten und unbesicherten Mittelstandsanleihen. Durch einen Vergleich der Entwicklung von nicht-ausgefallenen und ausgefallenen Anleihen versuchen wir diejenigen Ausstattungsmerkmale zu identifizieren, die Aufschluss über den Eintritt eines Ausfallereignisses geben könnten.
Cognitive dysfunction in corticobasal degeneration
Authors: Oliveira Laís Machado de , Barcellos Igor , Teive Hélio A.G. , Munhoz Renato Puppi
Published: August 2017

ABSTRACT Corticobasal degeneration (CBD) was originally described as a distinct clinicopathological entity in 1967. Since then, different phenotypic presentations have emerged as possible manifestations of CBD histopathological findings. In addition, pathophysiological findings and the molecular basis have been delineated and several aspects of its cognitive manifestations have been clarified. Thus, not only the spectrum of what is currently designated as CBD has expanded, but overlap with other degenerative and even secondary disorders has made clinical diagnostic certainty even more challenging in the absence of specific and readily-available markers. Cognitive deficits in CBD are now recognized as a frequent initial presentation and may appear up to eight years before the motor symptoms, depending on the phenotypic variant. Characteristic cognitive features of CBD involve language deficits, visuospatial and executive dysfunctions, apraxia, and behavioral disorders. Semantic and episodic memories are usually preserved, while language is often impaired in the early stages.
Middle cerebral artery aneurysms: aneurysm angiographic morphology and its relation to pre-operative and intra-operative rupture
Authors: Estevão Iracema Araújo , Camporeze Bruno , Araujo Jr Antonio Santos de , Nery Breno , Antunes Ápio Claudio Martins , Smith Timothy R. , Aguiar Paulo Henrique Pires de
Published: August 2017

ABSTRACT Objective Correlate the middle cerebral artery bifurcation aneurysm morphology with the pre-operative and intra-operative risk of rupture. Methods Forty patients with 46 middle cerebral artery bifurcation aneurysms were treated microsurgically by the same surgeon. Aneurysms were classified according to shape and the Fisher test was applied to analyze the effect of morphology on the pre-operative and intra-operative rupture. Results Pre-operative and intra-operative ruptures were observed in 8/46 patients (17.4%) and 14/46 patients (30.4%) respectively. Thirty-two cases (69.6%) had no symptoms postoperatively, modified Rankin score (MRS) of 0; 6.5% had MRS of 1 (no significant disability); 13% had MRS of 2 (slight disability); 4.3% had moderately severe disability (MRS of 4); and there were 3 deaths (6.5%) post-operatively. The morphology was not directly related to the rupture rate. Conclusion In general, ruptures are not affected by the morphology or the studied variables. Larger series are needed to validate these outcomes.
Epidemiological and clinical factors impact on the benefit of riluzole in the survival rates of patients with ALS
Authors: Fávero Francis Meire , Voos Mariana Callil , Castro Isac de , Caromano Fátima Aparecida , Oliveira Acary Souza Bulle
Published: August 2017

ABSTRACT Objective To investigate the impact of epidemiological and clinical factors on the benefit of riluzole in patients with amyotrophic lateral sclerosis (ALS). Methods The survival rate of 578 patients with ALS (1999-2011) was analyzed by descriptive statistics and Kaplan-Meier curves. Considering the median of the sample survival time (19 months), patients were divided in two groups: below (B19) and above the median (A19). Kaplan-Meier curves compared the survival rates of patients treated with riluzole and with patients who did not take the medication. Results Riluzole increased the survival rates of patients with lower limb onset who were diagnosed after the first appointment in B19. Patients with bulbar onset and diagnosed on the first, or after the first appointment showed higher survival rates in A19. Males lived longer than females in both groups. Conclusion Epidemiological and clinical factors influenced the benefit of riluzole in the survival rates of patients with ALS.
The relationship between motor function, cognition, independence and quality of life in myelomeningocele patients
Authors: Luz Carolina Lundberg , Moura Maria Clara Drummond Soares de , Becker Karine Kyomi , Teixeira Rosani Aparecida Antunes , Voos Mariana Callil , Hasue Renata Hydee
Published: August 2017

ABSTRACT Motor function, cognition, functional independence and quality of life have been described in myelomeningocele patients, but no study has investigated their relationships. We aimed to investigate the relationships between motor function, cognition, functional independence, quality of life, age, and lesion level in myelomeningocele patients, and investigate the influence of hydrocephalus on these variables. We assessed 47 patients with the Gross Motor Function Measure (motor function), Raven’s Colored Progressive Matrices (cognition), Pediatric Evaluation of Disability Inventory (functional independence) and the Autoquestionnaire Qualité de vie Enfant Imagé (quality of life). Spearman’s correlation tests determined relationships between the variables. The Friedman ANOVAs determined the influence of hydrocephalus. Motor function was strongly related to mobility and lesion level, and moderately related to cognition, self-care and social function. Cognition and quality of life were moderately related to functional independence. Age correlated moderately with functional independence and quality of life. Hydrocephalus resulted in poorer motor/cognitive outcomes and lower functional independence.
Guillain-Barré syndrome: celebrating a century
Authors: Freitas Marcos R. G. de , Vidal Cecília M. , Orsini Marco
Published: August 2017

ABSTRACT A hundred years ago, Guillain, Barré and Strohl described a syndrome with a predominant motor acute or subacute polyneuritis, albumin-cytologic dissociation in the cerebrospinal fluid, and a benign course. Before them, many other authors, such as Landry, Duménil, Osler, and Grainger Stewart had described similar cases although they had not performed lumbar punctures. In this work, we outline certain features of the beginning of this famous syndrome.
Brazilian consensus on Duchenne muscular dystrophy. Part 1: diagnosis, steroid therapy and perspectives
Authors: Araujo Alexandra P. Q. C. , Carvalho Alzira A. S. de , Cavalcanti Eduardo B. U. , Saute Jonas Alex M. , Carvalho Elmano , França Junior Marcondes C. , Martinez Alberto R. M. , Navarro Monica de M. M. , Nucci Anamarli , Resende Maria Bernadete D. de , Gonçalves Marcus Vinicius M. , Gurgel-Giannetti Juliana , Scola Rosana H. , Sobreira Cláudia F. da R. , Reed Umbertina C. , Zanoteli Edmar
Published: August 2017

ABSTRACT Significant advances in the understanding and management of Duchenne muscular dystrophy (DMD) took place since international guidelines were published in 2010. Our objective was to provide an evidence-based national consensus statement for multidisciplinary care of DMD in Brazil. A combination of the Delphi technique with a systematic review of studies from 2010 to 2016 was employed to classify evidence levels and grade of recommendations. Our recommendations were divided in two parts. We present Part 1 here, where we describe the guideline methodology and overall disease concepts, and also provide recommendations on diagnosis, steroid therapy and new drug treatment perspectives for DMD. The main recommendations: 1) genetic testing in diagnostic suspicious cases should be the first line for diagnostic confirmation; 2) patients diagnosed with DMD should have steroids prescribed; 3) lack of published results for phase 3 clinical trials hinders, for now, the recommendation to use exon skipping or read-through agents.
A INFLUÊNCIA DA ASSISTÊNCIA DE ENFERMAGEM NO AJUSTAMENTO AO HOSPITAL DE CRIANÇAS ADMITIDAS NA VÉSPERA OU NO DIA DA OPERAÇÃO
Authors: Velloso Nahyda de Almeida
Published: August 2017

RESUMO O autor apresenta um estudo sobre o valor do cuidado de enfermagem para diminuir a ansiedade da criança e auxiliar sua adaptação à situação hospitalar, quando o período de hospitalização é de curta duração. Foi feito um estudo comparativo entre 21 crianças do grupo experimental, que receberam cuidados especais envolvendo brinquedos e outros relacionamentos afetivos, desde admissão até a alta hospitalar, e 17 crianças do grupo de controle, que receberam os cuidados comuns do hospital. Os dados indicam que as crianças que receberam cuidados especiais de enfermagem adaptaram-se mais facilmente à situação hospitalar.
APLICAÇÃO DE UM MÉTODO DE ORIENTAÇÃO SISTEMATIZADA PRÉ-OPERATÓRIA A PACIENTES PORTADORES DA ÚLCERA PÉPTICA
Authors: Kannebley Zuleika M.
Published: August 2017

RESUMO O objetivo deste trabalho foi identificar a influência da orientação pré-operatória na recuperação pós-operatória. O estudo limitou-se a pacientes adultos que se submeteram à gastrictomia por serem portadores de úlceras péptica. Vinte pacientes do grupo experimental, na véspera da cirúrgia, receberam a uma orientação pré-operatória planejada e a vinte pacientes do grupo controle foi omitida a mesma orientação. Os principais dados obtidos demonstraram que o número de complicações pós-operatórias foi menor no grupo experimental do que no grupo controle, assim como foi menor a média dos dias de permanência no hospital após a cirurgia.
SEGURANÇA DO PACIENTE EM SALA DE OPERAÇÕES: O ENFERMEIRO E A UNIDADE DE ELETROCIRURGIA
Authors: Castellanos Brigitta Pfeiffer
Published: August 2017

A unidade de eletrocirurgia é um aparelho eletrônico que tem como objetivo promover a eletrocoagulação e a eletrodissecção. Como qualquer outro equipamento eletrônico, seus benefícios potenciais podem ser anulados, ou seu uso pode levar a desastrosas conseqüências, caso haja omissão ou desconhecimento com relação ao seu funcionamento, manejo e conservação. A avaliação das circunstâncias que envolvem queimaduras e problemas de interferência no paciente e em outros equipamentos eletrônicos contribui para maior segurança do paciente na sala de operações (S.O.). São analisadas as possíveis causas de queimaduras e é focalizado o papel do enfermeiro.
COMO ENSINAR O USO CORRETO DO DIAFRAGMA EM EXERCÍCIOS RESPIRATÓRIOS
Authors: Araújo Célia P.
Published: August 2017

Pacientes podem não saber usar corretamente seu diafragma em exercícios respiratorios. O enfermeiro pode ajudá-los colocando suas mãos com pequena pressão sobre a região infra-mamária e infra-axilar do paciente durante a inspiração, e este na expiração deverá contrair sua musculatura abdominal. Isto facilitará a aprendizagem da respiração torácico-diafragmática enquanto o paciente adquire também, nesse processo, a percepção do movimento do diafragma
PLANO DE ENSINO DE ENFERMAGEM EM CENTRO CIRÚRGICO
Authors: Gibertoni Jeny , Salzano Sonia Della Torre , Castellanos Brigitta Pfeiffer , Jouclas Vanda Maria G. , Posso Maria Belén , Marchetti Ana Maria
Published: August 2017

Todas as atividades realizadas no Centro Cirúrgico tem como finalidade o paciente, justificando a inclusão da disciplina Enfermagem em Centro Cirúrgico no Currículo das Escolas de Enfermagem. Dado o reduzido tempo disponível o programa e' desenvolvido de maneira a enfatizar principios e dar experiências básicas que serão aplicadas e suplementadas posteriormente. O presente trabalho traz o plano de Ensino da disciplina e os roteiros utilizados pelos alunos.
PRESCRIÇÃO DIÁRIA DE ENFERMAGEM: CONDIÇÕES PARA A SUA IMPLANTAÇÃO COMO ATIVIDADE DE ROTINA DA ENFERMEIRA
Authors: Friedlander Maria Romana
Published: August 2017

Relato de uma experiência na qual procurou-se levantar e verificar as dificuldades e condições necessárias para a implantação da prescrição diária de enfermagem, como atribuição da enfermeira encarregada de uma unidade em um hospital geral, cujo campo é utilizado para ensino. Descrição das etapas que foram desenvolvidas e providências tomadas para a solução dos problemas que se iam verificando a cada passo da implantação.
ASPECTOS BÁSICOS DA ASSISTÊNCIA DE ENFERMAGEM NO ATENDIMENTO DA NECESSIDADE DO CUIDADO COM O REVESTIMENTO CUTÂNEO-MUCOSO EM PACIENTE HOSPITALIZADO
Authors: Horta Wanda de Aguiar
Published: August 2017

O cuidado com o revestimento cutâneo-mucoso é básico em todas as culturas e suas manifestações e atendimento sofrem a influência de vários fatores, entre elas a doença. Na assistência de enfermagem ao paciente hospitalizado parte-se da observação das condições da pele e mucosa e investigação de hábitos para se chegar à identificação dos problemas, determinação da dependência de enfermagem e prescrição dos cuidados de enfermagem Esta envolve cuidados gerais e específicos levando-se em consideração as condições de deambulação, os problemas e a individualidade de cada paciente
Psicoterapia de Crianças: Desenvolvimento da Versão em Português do Child Psychotherapy Q-Set
Authors: Ramires Vera Regina Rohnelt , Schneider Celeste
Published: August 2017

RESUMO A literatura científica reconhece a necessidade de aprofundar o conhecimento sobre o processo terapêutico de crianças, compreendendo os mecanismos pelos quais se produzem mudanças. Para isso, precisamos de instrumentos que viabilizem tais investigações. O objetivo deste estudo foi traduzir e adaptar para o português brasileiro o Child Pychotherapy Q-Set (CPQ), instrumento que visa à análise do processo psicoterapêutico de crianças. O estudo foi desenvolvido em quatro etapas, avaliando-se a equivalência entre a versão traduzida e o instrumento original em quatro áreas: equivalência semântica, idiomática, experiencial e conceitual. Constatou-se que a versão em português do CPQ apresentou boa equivalência com a original e a fidedignidade interavaliadores foi satisfatória. As possibilidades de utilização oferecidas pelo CPQ foram discutidas.
Transformações das Identidades Coletivas em Comunidade no Alto Solimões/AM
Authors: Calegare Marcelo Gustavo Aguilar , Higuchi Maria Inês Gasparetto
Published: August 2017

RESUMO Este artigo apresenta estudo realizado em comunidade da zona rural do município de Tabatinga/AM, onde foi investigada a transformação das identidades coletivas de seus moradores por meio de pesquisa qualitativa. Entre 2006 e 2011, foram realizadas viagens a campo nas quais foram utilizadas observação participante, entrevistas semiestruturadas e genograma. A relação entre origem da comunidade, laços de parentesco, lideranças, lutas comunitárias e transformação das identidades coletivas é apresentada. Esses processos estão relacionados à religião da Santa Cruz, às práticas produtivas e à origem cultural-territorial. Discute-se que a busca de benefícios une os moradores e que uma das estratégias de acesso a direitos sociais foi a mudança identitária de caboco amazonense a indígena das etnias Tikuna e Kokama.
Vieses Cognitivos entre Consumidores num Dilema Social Simulado: Falso Consenso, Erro Fundamental de Atribuição, de Ator-Observador e de Autosserviço
Authors: Iglesias Fabio , Franco Víthor Rosa , Gisler Júlia Villela Teixeira , Piasson Douglas Leite
Published: August 2017

RESUMO Decisões entre cooperar e competir são fundamentais em dilemas sociais, quando interesses individuais de consumo estão em conflito com benefícios coletivos. O objetivo desta pesquisa foi testar a ocorrência de vieses de cognição social em um dilema simulado, com base nos procedimentos de (Gifford e Hine, 1997). Após jogarem o software FISH em condições de cooperação e competição, os participantes relataram suas auto e hetero percepções. Foram verificados o viés de falso consenso e o erro fundamental de atribuição, mas os vieses de autosserviço e o ator-observador se mostraram efeitos mais limitados e apenas entre cooperadores. Discutem-se algumas implicações teóricas, metodológicas e práticas dos fenômenos no contexto do consumo sustentável.
Violência doméstica e trabalho: percepções de mulheres assistidas em um Centro de Atendimento à Mulher
Authors: Echeverria Jasmin Gladys Melcher , Oliveira Maria Helena Barros de , Erthal Regina Maria de Carvalho
Published: August 2017

RESUMO O presente artigo tem como objetivo analisar as relações entre mulheres em situação de violência doméstica e o seu trabalho, a partir das percepções de mulheres agredidas por seus companheiros ou ex-parceiros atendidas em um Centro de Atendimento à Mulher no estado do Rio de Janeiro. A metodologia seguiu uma abordagem qualitativa, por meio de levantamento bibliográfico, trabalho de campo, utilização de observação participante, levantamento documental e entrevistas individuais. Como resultado, destaca-se que a violência doméstica afeta o rendimento e rotina de trabalho dessas mulheres. Entretanto, o trabalho também é visto como uma saída da situação de violência a qual estão submetidas.
A satisfação no trabalho da equipe multiprofissional que atua na Atenção Primária à Saúde
Authors: Tambasco Letícia de Paula , Silva Henrique Salmazo da , Pinheiro Karina Moraes Kiso , Gutierrez Beatriz Aparecida Ozello
Published: August 2017

RESUMO Esta pesquisa objetivou conhecer o nível de satisfação e a importância do trabalho para a equipe multiprofissional de Atenção Primária à Saúde. Trata-se de pesquisa quantitativa e de caráter exploratório, transversal. O nível de satisfação dos profissionais foi classificado no escore bom, porém, algumas questões indicaram baixo grau de satisfação. O grau de importância do trabalho destacou-se em nível mais elevado nas questões relacionadas à qualidade do trabalho desenvolvido e à comunicação com a equipe. Conclui-se que existe a necessidade de mudanças na gestão organizacional, especialmente no que diz respeito à ampliação de recursos humanos e materiais, pois identificam-se como indicadores expressivos que contribuem para menor satisfação com o trabalho e alto impacto sobre a saúde do trabalhador.
Avaliação do trabalho na Atenção Primária à Saúde do município do Rio de Janeiro: uma abordagem em saúde do trabalhador
Authors: Castro Mariana Monteiro de , Oliveira Simone Santos
Published: August 2017

RESUMO O objetivo deste estudo foi analisar a avaliação do trabalho na Atenção Primária à Saúde do município do Rio de Janeiro, com foco na saúde do trabalhador. Participaram da pesquisa 62 trabalhadores inseridos nas Equipes de Saúde da Família de três unidades de saúde, localizados na Área Programática 2.1. Parte-se do ponto de vista da atividade utilizando o dispositivo ergológico Encontro sobre o Trabalho. Lançou-se mão do Questionário de Saúde e Trabalho no Setor de Serviço. O estudo evidenciou que a avaliação do trabalho deve ser fundamentada no conhecimento específico do real da atividade, acessível apenas pela vivência do indivíduo que trabalha e pela mobilização subjetiva dos trabalhadores tanto individual como coletiva.
Desafios da comunicação em Unidade de Terapia Intensiva Neonatal para profissionais e usuários
Authors: Campos Carla Andréa Costa Alves de , Silva Luciano Bairros da , Bernardes Jefferson de Souza , Soares Andressa Laiany Cavalcante , Ferreira Sonia Maria Soares
Published: August 2017

RESUMO Comunicar notícias com sensibilidade é competência dos profissionais de saúde. Para analisar falas de profissionais e familiares de internos da Unidade de Terapia Intensiva Neonatal de um Hospital Universitário, foi realizada pesquisa qualitativa tendo como instrumentos entrevistas e Roda de Conversa, norteados pelo protocolo SPIKES. As categorias produzidas foram analisadas por meio das Práticas Discursivas e Produção de Sentidos. Os resultados evidenciaram ambiência desumanizada; sobrecarga de serviço; ausência de local e falta de treinamento para comunicar notícias e apontam a importância de valorizar a comunicação em saúde para melhorar a qualidade do trabalho e relações interpessoais.
Fatores de riscos ocupacionais e implicações à saúde do trabalhador em biotérios
Authors: Souza Gabriele Fatima de , Ferreira Aldo Pacheco , Moreira Maria de Fátima Ramos , Portela Luciana Fernandes
Published: August 2017

RESUMO Estudo transversal que avaliou as implicações à saúde dos trabalhadores de biotérios, bem como fatores de risco inerentes, em uma Instituição Federal de Ciências e Tecnologia. Os dados foram coletados por meio de um questionário semiestruturado e observação participante, em 2014. Foi evidenciado que os trabalhadores dos biotérios pesquisados em geral têm suas funções relacionadas com os fatores de risco físico, de acidente, ergonômico, biológico e organizacional/psicossocial. A pesquisa refletiu o quadro atual de deterioração das relações trabalho-saúde, sinalizando a necessidade de atualização constante no monitoramento na atenção à saúde desses trabalhadores.
Estudo espacial de riscos à leptospirose no município do Rio de Janeiro (RJ)
Authors: Chaiblich Juliana Valentim , Lima Maria Luciene da Silva , Oliveira Raiane Fontes de , Monken Maurício , Penna Maria Lucia Fernandes
Published: August 2017

RESUMO A leptospirose é relevante para saúde pública pela sua gravidade e modo de disseminação, cuja ocorrência é maior em local com vulnerabilidade socioambiental. No município do Rio de Janeiro, os casos estariam relacionados com sua estrutura social e espacial. Analisou-se a espacialidade da leptospirose nesse município, de 2000 a 2010, por meio de mapas e observações de campo. Resultados sugeriram que os bairros de Barra de Guaratiba, Pedra de Guaratiba e Grumari foram de alto risco - locais com estruturas sanitárias precárias e constantes alagamentos. Ações da Vigilância em Saúde são de grande importância na identificação e intervenção em locais de situações risco à saúde.
El territorio como categoría fundamental para el campo de la salud pública
Authors: Borde Elis , Torres-Tovar Mauricio
Published: August 2017

RESUMO Este ensayo hace una aproximación conceptual a la categoría 'territorio', vinculándola como categoría de análisis fundamental en salud pública. Se hizo una revisión de fuentes academicas en donde la geografía, las ciencias sociales y la salud se interrelacionan para reconocer como se concibe el territorio dentro del campo de la salud. La primera parte del texto aborda el territorio como ámbito de expresión del bienestar y malestar de la sociedad a partir de tres casos de configuración territorial. En la segunda parte se propone una discusión sobre la influencia/el papel el territorio en el campo de la investigación salud pública; lo que permite concluir que en el territorio se dan los procesos de producción y reproducción social, que constituyen la base de la determinación social de la salud-enfermedad-muerte.