bluuebunny/crossref_metadata_2025 huggingface dataset:
Aynı marka cihazlarda çalışılan testlerin six sigma metrikleri ile analitik performansının değerlendirilmesi
Authors: DUNDAR Bagnu , HALIPCI TOPSAKAL Hatıce Nur
Published: June 2023

Amaç: Altı sigma ile analitik testlerin istenilen kalitede olup olmadığı ve kalitenin sayısal değeri görülebilir. Laboratuvarlara sunulan testlerin yöntem kalitesini değerlendirmek, cihazlar arasında yöntem performansını karşılaştırmak, kalite kontrol prosedürlerini yeniden gözden geçirmek konusunda altı sigma metriklerinden faydalanılmaktadır.

Gereç ve Yöntemler: Bu çalışmanın amacı; laboratuvarda aktif çalışılan aynı marka cihazlar arasındaki altı sigma metrikleri ile analitik performansın değerlendirilmesi ve laboratuvar test çalışma hızına göre bu cihazlarda hangi testlerin çalışılıp çalışılmayacağı sorusuna yanıt bulmaktır. Yapılan araştırmada bütün testler ABBOTT marka Architeck c 8000 ve Architeck ci 4000 cihazlarında 6 ay süre ile çalışılmıştır. Glukoz (Glc), üre (BUN), kreatinin (CREA), aspartat aminotransferaz (AST), total kolesterol (CHOL), trigliseritler (Tg), Sodyum (Na), potasyum (K), klor (Cl) parametreleri değerlendirilmiş testlerin sigma değerleri performans yaklaşımına göre hesaplanmış ve cihazlar arasında karşılaştırma yapılmıştır. Toplam kabul edilebilir hata ( TEa), Klinik Laboratuvarları İyileştirme Yasası (CLIA) klavuzlarından alınmıştır. Bias, yeterlilik test verilerine göre belirlenmiştir. Biyokimyasal analitler için varyasyon katsayısı (CV) laboratuvarımızın IQC kayıtlarından elde edilmiştir. Sigma metrikleri (SM) = ( TEa-%Bias )/ %CV formülüne göre hesaplanmıştır

Bulgular: 6 ay boyunca yapılan karşılaştırılmalı takipte ay bazında hangi cihazda çalışılması gereken parametrelerin belirlenmesi değişkenlik göstermiştir. Laboratuvarımızda en fazla çalışılan glucose, urea ve creatinine testlerinin Architeck ci 4000 cihazında sigma değerleri Architeck c8000 cihazından daha düşük olduğu için bu testlerin sadece c8000 cihazında çalışılmasına karar verildi. Elde edilen metriklere göre, 2019 Ekim ayından itibaren başlattığımız çalışmada altı ay sonra elektrolitlerin tek cihazda çalışılmaya başlanması ile sigma değerinde artış tespit edildi.

Sonuç: Altı sigma metrikleri, binlerce test yapılan aynı marka cihazların yöntem performansını değerlendirmede aylık olarak özellikle düşük biyolojik varyasyona sahip testleri takip etmek için kullanılmalıdır.
Diagnostic Accuracy and Safety of Ultrasound Guided Omental Biopsy: Single Center Experience
Authors: ÖZEN Özgür , ZEYDANLI Tolga , KİRİSCİ Batuhan , KARAKAYA Emre
Published: June 2023

Aim: Omental biopsy has conventionally been performed using a surgical approach. The thickened omentum can serve as a useful target for ultrasonography guided percutaneous biopsy, in clinical practice. The objective of our study was to determine the diagnostic value and safety of ultrasound guided percutaneous biopsy of omental thickening. Additionally, we aim to investigate the correlation of biopsy results with the paracentesis fluid cytology.

Methods: This retrospective study included 49 patients (33 women and 16 men; mean age, 64 ± 13.9 [SD] years) who underwent ultrasound guided omental biopsy between 2014 and 2022 at a single institution at which US served as the first-line modality for omental biopsy guidance. Post-biopsy clinical follow-up were reviewed for each patient. We compare the outcomes of biopsy and paracentesis fluid cytology results.

Results: Total 49 patients were included in our study. US-guided biopsy was diagnostic in 46/49 (93.8%) of patients. There were total 36 (73.4%) malignant cases, 5 (10.2%) chronic inflammation suggestive of tuberculosis, while 2 (4.1%) were chronic peritoneal infection. In 3 patients, the result of core biopsy was benign and reported as Ig4-related inflammatory pseudotumor, desmoid fibromatosis and fat necrosis-foreign body reaction. Out of 36 malignant cases, majority 17 (47.2%) had ovarian cancer. There were no major complications. In 21 of 25 patients (%84) who underwent paracentesis fluid sampling, cytology results (malign or bening cytology) were found to be consistent with omental biopsy results. The ascitic cytological evaluation was favourable for malignancy in 16/25 (64%) patients.

Conclusions: Ultrasound-guided percutaneous biopsy of omentum is less expensive, safe and effective method with a high diagnostic accuracy. Paracentesis fluid cytology results are highly sensitive in patients with omental thickening.
ОЦІНЮВАННЯ РІВНЯ ЕКОНОМІЧНОЇ БЕЗПЕКИ ВАГОННОЇ ДІЛЬНИЦІ ТА ВИЯВЛЕННЯ ЧИННИКІВ ВПЛИВУ (НА ПРИКЛАДІ ПОЛТАВСЬКОЇ ВАГОННОЇ ДІЛЬНИЦІ АТ «УКРАЇНСЬКА ЗАЛІЗНИЦЯ»)
Authors: Назаренко І. Л. , Воробйова А. В.
Published: June 2023

В статті отримала подальший розвиток методика оцінки рівня економічної безпеки вагонної дільниці з урахуванням більшої кількості локальних показників, що дозволяє точніше визначати рівень економічної безпеки вагонної дільниці та розробляти ефективніші заходи з його підвищення. Виконані розрахунки рівня економічної безпеки Полтавської вагонної дільниці за 2016 – 2020 рр., які показали колосальне зменшення рівня економічної безпеки у 2020 році порівняно з 2016 роком, а особливо з 2019 роком. Виявлені чинники зменшення рівня ЕБ вагонної дільниці у 2020 році порівняно з 2019 роком за допомогою діаграми Ісікави.
ДЕРЖАВНА РЕГІОНАЛЬНА ПОЛІТИКА УКРАЇНИ В УМОВАХ ЄВРОІНТЕГРАЦІЇ: СТАН ТА ПЕРСПЕКТИВИ РОЗВИТКУ
Authors: Зайцева А. С. , Павленко В. С.
Published: June 2023

В області регіонального розвитку та підприємницьких умінь і популяризації підприємницької культури України вдалося домогтися успіхів у розробці програм з підтримки регіонів, а саме створення клубів підприємців, сприяння експорту та заохочення відповідального поведінки. У той же час необхідно докласти додаткових зусиль для підвищення фінансової грамотності, розвитку соціального підприємництва і заохочення навчання протягом усього життя. Про це свідчить значний прогрес в області підприємницької діяльності в окремих регіонах і розвитку підприємницьких структур по країні, а також про незначне прогрес в сфері вищої освіти та професійної підготовки взагалі.
СТРАТЕГІЧНІ НАПРЯМИ ПІДВИЩЕННЯ ІННОВАЦІЙНОЇ АКТИВНОСТІ ПІДПРИЄМСТВ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ
Authors: Кузнецов Є. М.
Published: June 2023

В статті досліджено підходи до визначення змісту інноваційної активності, що лягло в основу формулювання авторського розуміння категорії «інноваційна активність підприємств залізничного транспорту». Окреслено специфіку інноваційної діяльності підприємств залізничного транспорту та  визначено причини  загальнодержавного і галузевого впливу, що зумовлюють низький рівень інноваційної активності підприємств галузі. Обґрунтовано стратегічні напрями підвищення інноваційної активності підприємств залізничного транспорту.
НАУКОВО-ПРАКТИЧНИЙ ПІДХІД ДО РОЗПОДІЛУ ЕКСПЛУАТАЦІЙНИХ ВИТРАТ НА УТРИМАННЯ ВАНТАЖНИХ СТАНЦІЙ В УМОВАХ НЕВИЗНАЧЕНОСТІ
Authors: Калабухін Ю. Є. , Зоріна O. I. , Каменева Н. М. , Мкртичьян О. М.
Published: June 2023

В умовах, коли експлуатаційні витрати вантажних станцій регіональної філії АТ «Українська залізниця», крім витрат на оплату праці та відрахування на соціальні заходи, носять узагальнений характер і відображають витрати всіх станцій, що входять до складу структурного підрозділу регіональній філії, виникає проблема визначення експлуатаційних витрат окремої станції. В статті запропонований науково-практичний підхід до розподілу фактичних  експлуатаційних витрат на утримання вантажних станцій у т.ч. збиткових, в умовах невизначеності. Даний підхід дозволяє оцінити експлуатаційні витрати кожної окремої вантажної станції  регіональної філії з метою  подальшого достовірного визначення рівня ефективності їх виробничо-господарської діяльності.
Critical Perspective on Salafism in the Netherlands
Authors: Welten Liselotte , Abbas Tahir
Published: June 2023

The study establishes how Salafism has been able to influence Dutch Muslim communities in the current period. Through exploratory research, fifteen ‘expert’ interviews with members from the Dutch Muslim community were conducted. They indicated several shortcomings due to having to endure interventionistic policies that have thus far failed to curb the rise in Salafist recruitment. The analysis also reveals a range of misconceptions currently held regarding the Salafism phenomenon. We argue that statements made by public political figures and the varying definitions used within governmental publications and policy-decisions have caused a disproportionate focus placed upon ordinary Dutch Muslims. As a consequence, it enforces an Islamophobic perspective that diminishes the ability of Dutch Muslims to cooperate with the security services. The process of securitizing Salafism as a whole has led to the Dutch Muslim community to self-censor and self-isolate while experiencing restricted freedom of religion. The process of securitisation reframes the current understanding of Salafism as a greater societal threat.
Evolution of Jihadism in Finland
Authors: Malkki Leena , Saarinen Juha
Published: June 2023

Since the outbreak of the Syrian civil war in 2011, the broader European jihadist milieu has undergone significant transformation. One of these is the appeal of jihadist activity has expanded significantly beyond its traditional core areas, including Germany, France, the United Kingdom and Belgium. This research report maps the evolution of jihadism in one of the more peripheral countries in the European jihadist milieu, Finland. While Finland has only had limited exposure to the phenomenon, in the last decade the number of people involved in jihadist activism has increased significantly, and their internal organisation and contacts with transnational networks and armed groups deepened. The report also discusses potential future developments and ideas for further research.
Pathways out of the Quagmire ? Perspectives for al-Quaeda in the Sahel
Authors: Boeke Sergei
Published: June 2023

This article focuses on counter-terrorism efforts against al-Qaeda in the Islamic Maghreb (AQIM) and the Group for the Support of Islam and Muslims (JNIM), its main confederation of combat units. Using literature on how terrorist groups end, the article analyses perspectives for AQIM and JNIM. It describes the conceptual distinction between insurgency and terrorism, and structures insights along six pathways of decline, namely reorientation, repression, decapitation, negotiation, failure or success. JNIM is currently fighting a large-scale insurgency in Mali, Niger and Burkina Faso, while policy responses remain grounded in the paradigm of counter-terrorism, not counter- insurgency. The search and destroy missions of recently terminated Operation Barkhane did not manage to secure areas, and tactical successes were offset by targeting errors and exactions, fuelling jihadist recruitment. Leadership decapitation – also a focus of future French counter- terrorist efforts - has proved ineffective. The option of negotiations merits further exploration, but France and the Sahelian countries diverge in their approaches. Bottom-up ceasefires have improved local security in some areas, but risk benefiting AQIM in the long term. Finally, violent conflict between AQIM and the Islamic State in the Greater Sahara (ISGS) has hurt both groups, and their vulnerabilities to internal strife and the loss of public support could be leveraged more in counter-terrorism efforts.
Experimental identification of the electrical discharge on a surface gap spark plug
Authors: Szwajca Filip , Wisłocki Krzysztof
Published: June 2023

The main objective of the research is to assess the influence of the spark plug electrodes geometry on the structure of the electric arc. This issue is increasingly important in modern gas-fueled engines with lean and stratified air-gas mixtures. To explain the influence of electrode geometry on selected spark discharge indicators, optical tests were conducted, and the parameters of the test history, together with the movies of the discharging process, were recorded and analyzed. The tests were carried out comparatively for two types of spark plugs on the test stand: conventional spark plug and spark plug with a flat ground electrode. It has been found that using flat plug electrodes allows a larger spark area covered by the electric arc without losing the intensity of radiation. More, using an unconventional spark plug results in a shorter discharge time relative to the conventional spark plug, while the geometry of the conventional spark plug allows for maintaining a stable electric arc with a minimum tendency for creeping.
Peer Mentoring in Practice
Authors: Cust Fiona , Cope Laura , Brown Lucie , Baker Tracey
Published: June 2023

Theurer et al (2020) suggests that peer mentoring may be defined as a strategy offered to peers that includes the provision ofongoing emotional support or shared empathy.

At the author's university it was recognised that the ongoing implications of a pandemic has impacted significantly upon healthcare students mental health, and anxiety levels were greatly increased.

Any strategies that may potentially assist students within their training program should be acknowledged and facilitated. Peer mentoring was suggested as an initiative that may help to reduce anxiety and promote mental wellbeing.
Failing a social work practice placement: Differences between male and female students across Ireland
Authors: Hayes Davy , Roulston Audrey , O'Connor Erna , Shore Caroline
Published: June 2023

This paper reports findings of a secondary analysis of quantitative and qualitative data gathered during a larger study of social work students who failed a practice placement during the years 2015-2019 in four Irish Universities. The study highlighted an over-representation of males in the sample (Authors’ Own, 2021) but did not examine gender differences in detail. This paper sets out to address this deficit by exploring differences between male and female students who failed a practice placement.

 

The findings are limited in explaining the disproportionately high rate of fail outcomes for male students but do highlight some differences between males and females in terms of reasons for failure. Firstly, males had significantly fewer recorded reasons for failure than females. Secondly, different combinations of reasons for a fail recommendation were found between males and females. Moderately significant associations, for example, were found between being female and having poor written work and poor reflection cited as reasons for failure and males were more likely to fail due to poor professional conduct.

 

These findings are discussed with reference to previous studies, concluding that further research is required to better understand why males are more likely to fail practice placements than their female counterparts.
The experience of co-practice teaching in social work; an exploratory case study of what works in practice.
Authors: Allen Jennifer , Robinson Gay
Published: June 2023

Social work placements are a core component of professional social work programmes in Ireland, providing a valuable opportunity to integrate students understanding of theory, values, skills, and practice. Placements are predominantly provided by a sole social work practice teacher; however, some social workers share the practice teaching role with a colleague. A scoping review revealed a dearth in the literature on studies focusing on co-practice teaching in social work. The study also takes place in the context of potential challenges in securing quality social work practice placements already occurring in other jurisdictions.
This exploratory small-scale case study utilises mixed methods to include the perspectives of the co-researchers, two practice teachers who have jointly hosted social work students on practice placement in an older adult mental health setting over a ten-year period, and former students. A reflective inquiry of the practice teacher’s experience was undertaken as an exploratory qualitative method, exploring the elements of ‘co-creation’, ‘co-planning’, ‘co-facilitating’, and ‘co-assessment’ derived from Jarvis and Kariuki (2017). Insights from student self-administered electronic surveys using qualitative questions incorporating qualitative responses, thematically analysed, though small in sample size indicate that overall, the experience of co-practice teaching is positively experienced by students.
Evaluation of the Lysyl Oxidase-Like 2 (LOXL2) inhibitory activity of pimaranes and their glycosyl derivatives
Authors: Ferreira Sandra , Rijo Patrícia , Costa João G. , Saraiva Nuno , Santos Beatriz , Uriel Clara , Goméz Ana María , Díaz-Lanza A. M. , Fernandes Ana S.
Published: June 2023

Lysyl oxidase (LOX) and LOX-like 1-4 (LOXL 1-4) enzymes catalyze the cross-linking of elastin and collagen in the extracellular matrix, facilitating cell migration and invasion. The inhibition of these enzymes, particularly LOXL2, has been suggested as a therapeutic strategy to prevent breast cancer metastasis. In this work, new natural LOXL2 inhibitors were searched from Aeollanthus rydingianus, a medicinal plant rich in bioactive products. Five pimarane diterpenoids, two isolated from the plant and three derivatives, were tested. These compounds have been described for their bioactive properties such as anti-tumor, anti-inflammatory, analgesic, and antibacterial activities. In this regard, we intended to explore the mechanisms of these compounds by studying their effects on LOXL2 activity. Two pimarane diterpenoids showed a mild LOXL2 inhibitory activity as evaluated by an Amplex Ultra Red-based technique. The cytotoxicity of the most active compound was analyzed by the MTT assay in the MDA-MB-231 cell line, representative of triple-negative breast cancer. This compound decreased cell viability as single agent and increased the cytotoxic effect of doxorubicin. Its glycoconjugate was considerably more toxic, likely due to a higher uptake by cancer cells. Keywords: breast cancer, lysyl oxidase-like 2, inhibitors, pimaranes, Aeollanthus rydingianus, MTT
KADIN KOOPERATİFLERİNDE YENİ ÜRÜN GELİŞTİRME SÜRECİ VE TASARIMCININ ROLÜ: KARABÜK ÜRETEN ELLER KOOPERATİFİ ÖRNEĞİ
Authors: KAYA KÖSE Ege , AKBULUT Dilek
Published: June 2023

Türkiye’de girişim, işletme ve üretim olarak yapılanmış birçok kadın kooperatifi bulunmaktadır. Bu makale
kadın kooperatiflerinde zanaat ve sürdürülebilirlik bağlamında yerel topluluklar ve tasarımcılar arasında
iş birliğiyle yeni ürün geliştirme sürecinde tasarımcının etkin rollerinin belirlenmesi konu edinmiştir.
Zanaatların tasarım yoluyla güçlendirilmesi çalışmaları literatürde yer alırken, sürecin tasarımcılar için nasıl
işlenebileceği hakkında bilgi eksikliği bulunmaktadır. Kadın kooperatiflerinde zanaatların güçlendirilmesine
yönelik tasarım müdahalelerinin belirlenmesinde işbirlikçi bir tasarım sürecinin aşamalarının açık olmaması,
tasarımcıların süreçte rollerinin tanımlanması gerekliliğini ortaya çıkarmaktadır. Kooperatif çatısı altında
örgütlenen ve yerel üretim gerçekleştiren kadınların katılımcı olduğu tasarımcı ve zanaatkar iş birliği ile yeni
ürün geliştirme süreci bir kadın kooperatifi örneği ile ele alınmıştır. Karabük Üreten Eller Kooperatifi’ne
üye altı katılımcı ile iki hafta süren ve üç uygulamadan oluşan çalıştay düzenlenmiştir. Çalıştay ses kaydı,
alan notları, çevrimiçi grup görüşmeleri ve fotoğraflar ile belgelenmiştir. Çalıştay süresince tasarımcı olan
araştırmacı, katılımcıların yeni ürün geliştirme sürecinde eylemin kolaylaştırılmasını, kolektif çalışmayı
sağlayan ve katılımcıların sonuç ürünü görselleştirebilecekleri bir süreci tasarlamıştır.
COMMEDIA DELL’ARTE IN THE CONTEXT OF THE RELATIONSHIP OF MASK AND INSTAGRAM FILTERS
Authors: GULİYEV Ziyad , ÖZERDEN Kerim Emre
Published: June 2023

The phonomenon of gamification and character-building is constantly evolving and transforming. With

the advancement of technology, narrative structures and means, individuals have expanded their ability to

construct fictional universes. New stages have been created in cyberspace through the use of multimedia tools

that were once used in theatre, cinema, and other areas of visual narration mediums. Social media platforms

now provide individuals with the opportunity to create their own stages and express themselves in reshaped

and narcissistic, ironic and critical ways. Through various filters and masks, users can rebuild themselves

in digital public environments. This research draws a comparison between Commedia Dell’Arte masks and

Instagram filters to analyze the theatrical effects of digital space as a stage for individuals in everyday life from

a conceptual perspective.

Within the scope of the research, two hypotheses will be tested. Firstly, the technical opportunities offered by

new media platforms have significant impact on the individual’s ability to create their own stage. Secondly,

the characteristics of comedy in the historical Commedia DellArte culture still exists in today’s digital world.
Assessment of role of the trauma centers located along Pakistan national highways in manmade disasters
Authors: Rashid Muhammad , Shahzad Naeem
Published: June 2023

Due to earthquakes, floods, tsunamis, civil wars, terrorism, etc., disasters are becoming more frequent and lethal on a daily basis throughout the world. One of the manmade disasters is traffic accidents, which result in serious injuries or can be fatal for people, particularly those between the ages of 1 and 44. Road accidents regularly put the lives of 1.25 million people in danger. More than 20 to 50 million people annually experience non-fatal injuries that could result in disability. While responding to a crisis, our main aim is to preserve lives. This is done in two steps: firstly, we manage the life-threatening injuries, and secondly, we work to prevent secondary injuries by dealing with the original injuries effectively. We require trauma centers and emergency medical services that are easily accessible for the avoidance of secondary injuries and their successful recovery. To provide care for patients who have sustained severe injuries, trauma centers offer the required tools, specialized resources, and a trauma team with specialized training. A trauma center may treat all of the same illnesses and injuries that are treated in an emergency room, and it can offer patients with catastrophic injuries prompt multi-disciplinary, all-inclusive emergency medical care. The objective of this study was to assess how trauma centers, particularly those close to highways, contribute to the management of trauma. A quantitative questionnaire was created for this purpose, and the information gathered was then statistically compared, contrasted, and analyzed. The study concludes that trauma management should be provided in close proximity to the site of incidents so that morbidity and mortality can be reduced.
Prediction model with artificial neural network for tidal flood events in the coastal area of bandar lampung City
Authors: Puspita Wulandari Eka Suci , Nurpambudi Ramadhan , Aziz RZ. Abdul
Published: June 2023

The fastest sea level rise began in 2013 and reached its highest level in 2021. This is part of the ongoing global warming impact, where polar ice continues to melt, glaciers also continue to melt, causing sea level rise. In the Bandar Lampung City area, there are several areas that are threatened with tidal flooding, namely Karang City Village and Kangkung Village, Bumi Waras Village, and Sukaraja Village. Bandar Lampung itself is the city center in the coastal area. Where the majority of the population is in the Coastal area so that the threat of tidal flooding is caused by rising sea levels. To study the occurrence of tidal floods in the past, this research uses an Artificial Neural Network which has the ability to study non-linear data which is then carried out by training and testing until the best configuration model is obtained. Based on the analysis and discussion that has been carried out, several important points can be drawn, including the results of training and dataset testing that has been carried out. , 80:20, and 90;10. This is evidenced by the results of the high accuracy of the model configuration and also the results of the prediction table which is able to describe the actual conditions, setting the model configuration experimentally is able to produce the best training accuracy value reaching 100% while for the best testing accuracy is 88%. The average correlation value of training with the 50:50 dataset is 0.975, the 60:40 dataset is 0.975, the 70:30 dataset is 0.951, the 80:20 dataset is 0.935, and the 90:10 dataset is 0.929. For the average value of the correlation test with the 50:50 dataset of 0.514, the 60:40 dataset is 0.362, the 70:30 dataset is 0.488, the 80:20 dataset is 0.284, and the 90:10 dataset is 0.402. Whereas the average error value for the 50:50 dataset is 0.006, the 60:40 dataset is 0.006, the 70:30 dataset is 0.010, the 80:20 dataset is 0.007, and the 90:10 dataset is 0.007, the flood prediction table is made based on 1 configuration the best with a training accuracy rate of 98% and a testing accuracy of 80% with an error value of 0.004, namely configuration model 14, this model is the best configuration model out of 3 dataset divisions out of a total of 5. The prediction table uses sea level tides of 1.5 meters. The prediction table is able to provide good tidal flood percentage values, especially when there are active astronomical phenomena. The results of this good flood prediction table illustrate that the backpropagation ANN is able to study datasets well and can be used by BMKG forecasters in making tidal flood early warnings.
Bell's Theorem Begs the Question
Authors: Christian Joy
Published: June 2023

I demonstrate that Bell's theorem is based on circular reasoning and thus a fundamentally flawed argument. It unjustifiably assumes the additivity of expectation values for dispersion-free states of contextual hidden variable theories for non-commuting observables involved in Bell-test experiments, which is tautologous to assuming the bounds of ±2 on the Bell-CHSH sum of expectation values. Its premises thus assume in a different guise the bounds of ±2 it sets out to prove. Once this oversight is ameliorated from Bell's argument, the bounds on the Bell-CHSH sum of expectation values work out to be ±2√2 instead of ±2, thereby mitigating the conclusion of Bell's theorem. Consequently, what is ruled out by the Bell-test experiments is not local realism but the additivity of expectation values, which does not hold for non-commuting observables in any hidden variable theories to begin with.
Investigating Possible Correlations Between Gamma-Ray and Optical Lightcurves for TeV-Detected Northern Blazars Over 8 Years of Observations
Authors: Acharyya Atreya , Sadun Alberto
Published: June 2023

Blazars are a subclass of Active Galactic Nuclei (AGN) having relativistic jets aligned within a few degrees of our line-of-sight and form the majority of the AGN detected in the TeV regime. The Fermi-Large Area Telescope (LAT) is a pair-conversion telescope, sensitive to photons having energies between 20 MeV-2 TeV, and is capable of scanning the entire gamma-ray sky every three hours. Despite the remarkable success of the Fermi mission, many questions still remain unanswered, such as the site of gamma-ray production and the emission mechanisms involved. The Asteroid Terrestrial-impact Last Alert System (ATLAS) is a high cadence all sky survey system optimized to be efficient for finding potentially dangerous asteroids, as well as in tracking and searching for highly variable and transient sources, such as AGN. In this study, we investigate possible correlations between the \textit{Fermi}-LAT observations in the 100 MeV-300 GeV energy band and the ATLAS optical data in the R-band, centered at 679 nm, for a sample of 18 TeV-detected northern blazars over 8 years of observations between 2015-2022. Under the assumption that the optical and gamma-ray flares are produced by the same outburst propagating down the jet, the strong correlations found for some sources suggest a single-zone leptonic model of emission.
Analysis of Cutting Forces at Transverse Sawing of Wood with SK and HSS Saw Blades
Authors: Krilek Jozef , Melicherčík Ján , Kuvik Tomáš , Kováč Ján , Gendek Arkadiusz , Aniszewska Monika , Mareček Jan
Published: June 2023

This research deals with the processing of wood using a circular saw, which is associated with several risks and factors that affect the wood splitting process. One of them is the wear of the teeth of the saw blade and the change in the size of the cutting forces. The aim of this study is to compare real measured values and theoretical values when processing Norway Spruce wood, using two types of saw blades SK and HSS with a diameter of 600 mm and the number of teeth 54 and 56. Experimental measurements were carried out on a special test device with the possibility of moving the tested wood into the cutting devices and a simple saw blade replacement system. The results of the contributions show significant differences, based on defined factors, which are supported by FEM analysis of cutting forces in the process of cutting wood - when changing the design of the saw blade. The results of the experiment show that the cutting conditions (cutting speed, feed speed) do not have a significant effect on the size of the cutting forces. The theoretical and real stress values for HSS discs ranged from 14 to 22 MPa. Significantly larger differences were recorded for discs with SK, where the real values of the maximum stresses were around 14 MPa and the theoretical ones around 25 MPa. When cutting spruce with a disc with SK slices, the maximum values of the the-oretical cutting forces were in the range of 76 to 94 N and the maximum values of the measured cutting forces were in the range of 40 to 44 N.
A Semi – Three Dimensional (3D) Bioprinted Neurocardiac System for Tissue Engineering of a Cardiac Autonomic Nervous System (CANS) Model
Authors: Hernandez Ivana , Ramirez Salma P. , Salazar Wendy V. , Mendivil Sarahi , Guevara Andrea , Patel Akshay , Loyola Carla D , Dorado Zayra N. , Joddar Binata
Published: June 2023

In this study, we designed a functional neuro-cardiac model to help us examine the role of neuronal regulation and confirm the importance of neural innervation techniques for cardiac tissue regeneration. A three-dimensional (3D) bioprinted neuro-cardiac scaffold composed of a mixture of gelatin-alginate and alginate-genipin-fibrin hydrogels was developed with a 2:1 ratio of AC16 cardiomyocytes (CMs) and retinoic acid differentiated SH-SY5Y neuronal cells (NCs) respectively. A unique semi-3D bioprinting approach was adopted where the CMs were mixed in the cardiac bioink and printed using an anisotropic accordion design to mimic the physiological tissue architecture in vivo. The voids in this 3D structure were methodically filled in using a NCs-gel mixture and cross-linked. Confocal fluorescent imaging using Microtubule-associated protein 2 (MAP-2) antibodies for labeling NCs, and the MyoD1 antibody for CMs revealed functional coupling between the two cell types in the final cross-linked structure. This data confirmed the development of a physiologically functional neuro-cardiac model that can be used to study neuro-cardiac modulation under physiological and pathological conditions.
Measurements of J/ψ Production vs Event Multiplicity in the Forward Rapidity in p + p Collisions in the PHENIX Experiment
Authors: Shi Zhaozhong
Published: June 2023

J/ψ, a charmonium bound state made of a charm and an anti-charm quark, has been discovered in the 1970s and confirmed the quark model. Because the mass of charms quarks is significantly above the Quantum Chromodynamics (QCD) scale ΛQCD, charmonia are considered as excellent probes to test perturbative Quantum Chromodynamics (pQCD) calculations. Over the past decades, they have been studied extensively at different high energy colliders. However, their production mechanisms, which involves multiple scales, are still not very well understood. Recently, in high multiplicity p+p collisions at RHIC and at the LHC, a significant enhancement of J/ψ production yield has been observed, which suggests a strong contribution from the Multi-Parton Interaction (MPI). This is different from the traditional pQCD picture where charm quark pairs are produced from a single hard scattering between partons in p+p collisions. In this work, we will report the J/ψ normalized production yield as a function of normalized charged particle multiplicity over a board range of rapidity and event multiplicity in the J/ψ→μ+μ− channel with PHENIX Run 15 p+p data at \sqrt{s}=200 GeV. The results are compared with PYTHIA 8 simulations with the MPI option on and off. Finally, the outlooks of J/ψ in p+Au and Au+p collisions along with Color Glass Condensate (CGC) predictions and of multiplicity dependent ψ(2S)/J/ψ ratio in p+p data will be briefly discussed.
A Comprehensive Review for Incorporation of Electric Vehicles and Renewable Energy Distributed Generation to Smart Grid
Authors: Ntombela Mlungisi , Musasa Kabeya
Published: June 2023

- Power grids of the future will likely incorporate more renewable energy distributed generation (REDG), also known as alternative energy systems. REDG units are increasingly being used in electrical transmission networks because to the overall positive effects they have on power networks. REDG systems are the backbone of smart electric networks and are essential to the operation of the smart grid. These REDG systems can additionally improve system reliability by providing some customers with a backup generator in the event of power interruptions. The report offers a thorough evaluation of the existing body of information on the topic of electric vehicles' (EVs') future interactions with the smart grid. The combination of the EVs' potential deployment and the smart grid's conceptual goal presents challenges in electric grid infra-structure, communication, and control. The proposal for connecting EVs to the grid is based on research into cutting-edge smart metering and communication systems. In the context of the vehicle-to-grid (V2G) phenomenon, the possibilities, benefits, and limitations of various EV smart charging systems are also fully examined. There is a fast growing percentage of distributed energy that is wind and solar photovoltaic. Their variable power output, however, introduces fresh challenges for those responsible for organizing, operating, and controlling the power grid. While fluctuations in the electric grid are problematic, they may be mitigated by the entry of EVs into the energy market. As such, we do a comprehensive literature search to learn more about the exciting research gap that needs to be filled and the most recent possible answer that involves EVs. Additionally, we take a close look at the practicality of the sophisticated V2G technology. The smart grid is a developing concept for the world's energy infrastructure, and this study analyzes in depth how EVs interact with it.
Psychometric Properties and Screening Performance of the Geriatric Depression Scale in a Mild-to-Moderate Cognitively Impaired Portuguese Sample
Authors: Justo-Henriques Susana Isabel , Pérez-Sáez Enrique , Carvalho Janessa O. , Bobrowicz-Campos Elzbieta , Apóstolo João A. , Otero Patricia , Vázquez Fernando L.
Published: June 2023

Although the Geriatric Depression Scale (GDS) is a well-established instrument for the assessment of depressive symptoms in older adults, this has not been validated specifically for Portuguese cognitively impaired persons. The objective of this study was to analyze the psychometric properties of two Portuguese versions of the GDS (GDS-27 and GDS-15) in a Portuguese mild-to-moderate cognitively impaired sample. Clinicians assessed for major depressive disorder and cognitive functioning in 117 participants with mild to moderate cognitive decline (76.9% female, Mage = 83.66 years). The internal consistency of GDS-27 and GDS-15 were 0.874 and 0.812, respectively. There was a significant correlation between GDS-27 and GDS-15 with Beck Depression Inventory-II GDS-27: rho = 0.738, p < 0.001; GDS-15: rho = 0.760, p < 0.001), suggesting good validity. A cutoff point of 15/16 in GDS-27 and 8/9 in GDS-15 resulted in identification of persons with depression (GDS-27: sensitivity 100%, specificity 63%; GDS-15: sensitivity 90%, specificity 62%). Overall, the GDS-27 and GDS-15 are reliable and valid instruments for the assessment of depression in Portuguese-speaking cognitively impaired persons.
HER2-positive Gastric Cancer: The Role of Immunotherapy and Novel Therapeutic Strategies
Authors: Pous Anna , Notario Lucía , Hierro Cinta , Layos Laura , Bugés And Cristina
Published: June 2023

Gastric cancer is an aggressive disease with increasing global incidence in recent years. Human epidermal growth receptor 2 (HER2) is overexpressed in approximately 10-20% of gastric cancers. The implementation of targeted therapy against HER2 as part of the standard of care treatment in metastatic disease has improved the prognosis of this subset of patients. However, gastric cancer still has high mortality rates and urgently requires new treatment strategies. The combination of immunotherapy with HER2-targeted therapies has shown synergistic effects in preclinical models, being the rationale behind exploring this combination in clinical trials in locally advanced and metastatic settings. Additionally, the irruption of antibody-drug conjugates and other novel HER2-targeted agents has led to the development of numerous clinical trials showing promising results. This review presents the molecular mechanisms supporting the use of HER2-targeted drugs in combination with immunotherapy and provides an overview of the therapeutic scenario of HER2-positive disease. We focus on the role of immunotherapy but also summarize emerging therapies and combinations under clinical research that may change the standard treatment in HER-2 positive disease in the future.
Fidelity Performance Research of Coring Bits during Drilling and Cutting in Deep Extreme Environments
Authors: Sun Fuda , Chen Ling , Li Yanyan , Wang Zhehao , Xiao Bin , Chen Zexiang
Published: June 2023

Keywords: Deep mining; Drill bit structural parameters; Fidelity coring; Abaqus simulation and analysis.
Loose Belt Fault Detection and Virtual Flow Meter Development Using Identified Data-driven Energy Model for Fan Systems
Authors: Wang Gang , Wang Junke , Tiamiyu Nurayn , Wang Zufen , Song Li
Published: June 2023

An energy model that correlates fan airflow, head, speed, and system power input is essential to detect device faults and optimize control strategies in fan systems. Since the application of variable frequency drives (VFDs) makes the motor efficiency data published by manufacturers inapplicable, the fan efficiency and drive (belt-motor-VFD) efficiency must be identified for each individual system to obtain accurate energy models. The objectives of this paper are to identify an energy model of existing VFD-motor-fan systems using available experimental data and demonstrate its applications in loose belt fault detection and virtual airflow meter development for optimal control. First, an approach is developed to identify the fan head, fan efficiency and drive efficiency curves using available fan head, speed, and system power input as well as temporarily measured airflow rate without measuring shaft power. Then the energy model is identified for an existing VFD-motor-fan system. Finally, the identified model is applied to detect the slipped belt faults and develop the virtual airflow meter. The experiment results reveal that the developed approach can effectively obtain the energy model of VFD-motor-fan systems and the model can be applied to effectively detect slipped belt faults and accurately calculate the fan airflow rate.
Availability of Production Inputs in Broiler Partnership In Sleman Regency Yogyakarta
Authors: Kusumastuti Tri Anggraeni , Widiati Rini
Published: June 2023

Broiler has now developed a pattern of partnership. This study aims to determine the characteristics of farmers, businesses, and the availability of production input in broiler partnerships. The research was conducted in Sleman Regency. Location in 3 sub-districts i.e. Pakem, Cangkringan, and Ngemplak. The number of samples of 64 respondents and the core of 5 companies was performed by the purposive method. The analysis was carried out descriptively and the results of the analysis were written in tabular form. The results showed that farmers belonged to the productive age (45 years), education senior high school (43.42%), experience (11.15 years), and basic work as farmers. The business scale was 6014 heads/ period with a maintenance period of 35-36 days/periods/year. The maintenance system was an open house (81.58%). In the partnership agreement, the availability, amount, and price of input come from the core. A relationship between business characteristics and the provision of production inputs in the broiler partnership pattern and the results were still not optimal. The improvement and review of contents of the contract need to be reviewed to generate benefits and justice.
Keywords: broiler, production input, partnership system
METHODOLOGICAL APPROACHES FOR ASSESSING THE QUALITY OF MULTI-PARAMETER ENERGY FACILITIES
Authors: Budanov Pavlo , Grinchenko Hanna , Nechuyviter Olesia , Tsykhanovska Iryna
Published: June 2023

The complex quality assessment of complex multivariate research objects is analyzed. It is emphasized that the current methodology for assessing the quality of multi-parameter objects, despite the heterogeneity of these objects, is based on common principles and methods of qualimetry associated with a particular system or group of systems that are part of this object and carry information on the quantitative parameters of the technological process and properties of the object but does not allow to determine a single integrated criterion for assessing the quality of the object. It has been found that when assessing the quality of a power facility, the main information and measurement systems do not have a process for forming comprehensive and integrated quantitative and qualitative indicators for assessing the quality of the facility. It is proposed to improve the information-measuring system of the software and hardware complex of the automated process control system of a power plant power unit, which, based on the analysis of individual quantitative and qualitative indicators of the quality of control and information flows (signals) on technological parameters, allows to establish and present the relationships between the structural elements of the facility and the process of forming the quality of electricity as the main quantitative and integral indicator of the facility quality assessment. The article substantiates the use of methods for assessing the level of electricity quality, which can be used both separately and in various combinations and allow: to ensure the obtaining of the final economic result, which allows making an economically sound decision in the production of electricity, and to more accurately assess the level of electricity quality when measured by various devices or when calculated are based on formulas that reflect objective laws. The stages of the sequence of work on the organization and conduct of qualimetric assessment of electricity quality are determined, which allows: to determine the purpose of assessing the level of electricity quality; to select the nomenclature of single and basic indicators for assessing the quality of electricity, as well as the choice of a qualimetric method for assessing the level of electricity quality. The application of instrumental (measuring), computational, and static methods of qualimetry, which allow calculations based on the values of quantitative parameters of electricity and can be used in practice when calculating the economic costs of electricity production at a power facility, is considered and substantiated.
APPLIED SOFTWARE FOR PERSONAL INFORMATION STORAGE
Authors: Tsybulnyk Serhii , Zubarskyi Dmytro , Pivtorak Diana
Published: June 2023

In today's world, the personal information of any person can be conventionally divided into two large categories: general and special. As you can understand from the name, the first category is responsible for the type of data that can be found in public access, namely: surname, first name, patronymic, signature, place and date of birth, citizenship, marital status, education, bank details, etc. Such a variety of personal data requires different methods and automated means of storage. Today, private and state institutions increasingly refuse to store information in paper form. This is explained by the low level of security of such storage facilities, which can be affected by fire, water, pests, etc. Information that exists in paper form is very easy to lose, for example, misplaced or lost during movement. It is shown that digital storage of information makes it possible to get rid of such problems. Personal data that is stored electronically can often be recovered even if the device from which it was accessed is lost. One of the main types of personal information in modern society is login data: login and password. That is why the algorithmic and software of the automated system for saving the user's personal data was developed. This system should enable the user to generate passwords resistant to standard hacking methods and store them in the database. The development of the automated system took place using the MVC architectural template, which is one of the options for implementing a multi-level architectural model. For detailed design and coding, an object-oriented Java programming language with static strict typing was chosen. It was also decided to develop an automated system in the form of a web application using the Spring framework. During the development process, a local database was designed, which will store personal data in the form of logins and passwords entered by the user or generated by the system itself. An algorithm for generating hack-resistant passwords has been developed. Hash algorithms are also used as an additional protection of the main password of the web application. A graphical interface has been created that allows the user to access the main functions of the automated system.