bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Associated with Medical Students’ Career Choices Regarding Internal Medicine in Uganda
Authors: Bongomin Felix , Olum Ronald , Kajjimu Jonathan , Kanyike Andrew Marvin , Atulinda Linda , Ninsiima Daphine , Wamala Nicholas Kisaakye , Byakika-Kibwika Pauline
Published: January 2022

Background
There is an unmet need for internal medicine physicians in Uganda owing to the growing burden of diseases. This study aimed at evaluating the factors associated with career choices of undergraduate medical students regarding internal medicine in Uganda.
Methods
We conducted a cross-sectional study in the first 3 weeks of October 2021 via WhatsApp messenger. Medical students in the 3rd to 5th year of study who had completed internal medicine clinical rotations and pursuing a Bachelor of Medicine and Bachelor of Surgery (MBChB) degree at 7 Ugandan universities (4 public and 3 private) were enrolled. Multivariable logistic regression model was constructed to determine factors associated with a career choice in internal medicine.
Results
We enrolled 418 participants, median age 24 (interquartile range (IQR): 23 – 26) years, 67.7% were male, and 36.1% had a family member or relative who was a doctor. Most of the students (84.0%) were interested in research. The top three most preferred specialties were internal medicine (52.6%), surgery (51.2%), and obstetrics & gynaecology (51.0%). Overall, 186 (44.5%) participants reported plans to pursue a Master of Medicine degree in internal medicine. Interest in research was the only factor independently associated with 2.5-fold higher odds of pursuing a career in internal medicine (adjusted odds ratio: 2.5, 95% CI: 1.4 — 4.6, p=0.003). About 73% of the participants strongly agreed that internal medicine requires wide reading.
Conclusions
There is strong interest to pursue a career in internal medicine among Ugandan medical students. We recommend increase in training opportunities in Internal Medicine especially in view of the growing disease burden and increasing population growth.
Point Cloud Semantic Segmentation with Cross-Correction Features
Authors: Zhao Yuehua , Jie Ma , Nannan Chong , Junjie Wen
Published: January 2022

Real time large scale point cloud segmentation is an important but challenging task for practical application like autonomous driving. Existing real time methods have achieved acceptance performance by aggregating local information. However, most of them only exploit local spatial information or local semantic information dependently, few considering the complementarity of both. In this paper, we propose a model named Spatial-Semantic Incorporation Network (SSI-Net) for real time large scale point cloud segmentation. A Spatial-Semantic Cross-correction (SSC) module is introduced in SSI-Net as a basic unit. High quality contextual features can be learned through SSC by correct and update semantic features using spatial cues, and vice verse. Adopting the plug-and-play SSC module, we design SSI-Net as an encoder-decoder architecture. To ensure efficiency, it also adopts a random sample based hierarchical network structure. Extensive experiments on several prevalent datasets demonstrate that our method can achieve state-of-the-art performance.
Compartmentalization and Interaction of Pax5 and Pax6 in Brain of Mice
Authors: Maurya Shashank Kumar , Mishra Rajnikant
Published: January 2022

Many transcription factors play important roles to maintain the microenvironment, integrity of the blood-brain barrier, the neurons-glia interaction, activities of microglia, composition of cerebrospinal fluid, metabolic activities, concentration of neurotransmitters, presence of inflammatory and anti-inflammatory cytokines, ischemia, stress, aging, neurological disorders, and diseases. The Paired box transcription factors and multifunctional proteins, Pax6 and Pax5 are expressed in brain. They regulate several regulators from cell cycle to cell death. The Pax5, a B-cell lineage-specific activator protein (BSAP), is expressed in the cerebellum, cerebral cortex, hippocampus, olfactory bulb, third ventricles, and choroid plexus. The Pax5 has been observed down-regulated in autism, mental retardation, and Glioblastoma multiforme. The Pax6 affects genes of neurodegeneration, immunological surveillance, and energy homeostasis in brain of mice. The Pax5 and Pax6 recognize several similar DNA sequences and regulate the expression of genes in a tissue-specific manner. Therefore, it is presumed that Pax5 and Pax6, are compartmentalized in brain of mice. Results indicate interactions, cell and tissue-specific compartmentalization, and co-localization of Pax5 and Pax6 in the cerebral cortex, cerebellum, and hippocampus in brain of mice.
Numerical Study of a Wide-angle Near-Perfect Absorber for the Visible Regime Incorporating Metal-Dielectric-Metal Subwavelength Grating Structure
Authors: Zou Wenlong , Zhang Heng , Zhou Yun
Published: January 2022

A near-perfect absorber for the visible regime based on metal-dielectric-metal subwavelength grating structure with the refractory metals is designed and demonstrated numerically. The absorber presents an average absorption over 98.4% in the visible regime at normal incidence. Angle-relative analysis shows that the proposed structure has good angle-tolerance. The high average absorption (86.6%) in the visible region can be maintained with the incident angles up to 60°. Through the analysis of the magnetic field, the physical origin is verified that this excellent absorption performance mainly stems from the cooperative effect of surface plasmonic resonances and the intrinsic broadband spectral responses by the refractory metals. In addition, the dependence of the absorption spectrum of the proposed absorber on the structural parameters is analyzed. This work provides an idea for the design of high-performance absorbers and has potential applications in advanced light energy capture and integration systems.
Predicting Parkinson’s Disease Related Genes Based on PyFeat and Gradient Boosted Decision Tree (GBDT)
Authors: Helmy Marwa , Eldaydamony Eman , Mekky Nagham , Elmogy Mohammed , Soliman Hassan
Published: January 2022

Identifying genes related to Parkinson's disease (PD) is an active and effective research topic in biomedical analysis, which plays a critical role in diagnosis and treatment. In recent years, many studies have proposed different techniques for predicting disease-related genes. However, a few of these techniques are designed or developed for PD gene prediction. Most of these PD techniques are developed to identify only protein genes and discard long non-coding (lncRNA) genes, which play an essential role in biological processes and the Transformation and development of diseases. This paper proposes a novel prediction system to identify protein and lncRNA genes related to PD that can aid in an early diagnosis. First, we preprocessed the genes into DNA FASTA sequences from the UCSC genome browser and removed the redundancies. Second, we extracted some significant features of DNA FASTA sequences using five numerical mapping techniques with Fourier transform and PyFeat method with Adaboost technique as feature selection. Finally, the features were fed to the gradient boosted decision tree (GBDT) to diagnose different tested cases. Seven performance metrics are used to evaluate the performance of the proposed system. The proposed system achieved an average accuracy (ACC) equals 78.1%, the area under the curve (AUC) equals 84.9%, the area under precision-recall (AUPR) equals 85.0%, F1-score equals 78.2%, Matthews correlation coefficient (MCC) equals 0.564, Sensitivity (SEN) equals 79.1%, and specificity (SPC) equals 77.1%. The experiments demonstrate promising results compared with other systems. The predicted top-rank protein and lncRNA genes are verified based on a literature review.
Transition Readiness in Adolescents and Young Adults With Chronic Rheumatic Disease in Oman: Today’s Needs and Future Challenges
Authors: Abdwani Reem , Sabri Rumaitha Al , Alhasni Zawan Zawan , Rizvi Seyad , Wahshi Humaid Al , Lawati Batool Al , Abrawi Safiya Al , Wali Yasser , Sadoon Mona Al
Published: January 2022

Introduction:In Oman, the “transfer” healthcare rather than the “transition” of health care of adolescents to adult care occurs at a young age, like many other GCC countries for cultural reasons. In order to address this concern, this study was conducted to determine the transition readiness skills of adolescents and young adults with childhood onset rheumatic diseases using a cross-cultural adaptation of the UNC TRxANSITION scale.Methods: We used a professionally translated/back translated, provider-administered UNC TRxANSITION Scale. This 32-question scale measures HCT in ten domains including knowledge about diagnosis or treatment, diet, reproductive health, school/work, insurance, ability to self-manage and looking for new health providers. The maximum transitional score of 10, was categorized as low (1-4), moderate (4 - 7) and high (7 -10) transitional readiness scores.Results:We enrolled 81 Omani adolescents and young adults (AYA) with chronic childhood onset rheumatic diseases. The cohort consisted of 79% females, with mean age of 15.8 years (± 3.53) and mean disease duration of 6.95 years (± 4.83). Our cohort's overall mean score is low 5.22 (±1.68). Only 14.8% of the cohort achieved a high transition score ≥7). Significant direct relationship was observed between age and the mean transition readiness score (r = .533, P < .001). The mean transition readiness score in the younger age group (10-13 years) was 4.07 (±1.29), the middle age group (14-18 years) was 5.43 ( ±1.27), while the older age group (19-21 year), was 6.12 ( ±1.81), Mean transition score of youngest age group was found to be significantly lower than the other two age groups (p =.003).Conclusion:Overall, the transition readiness of AYA in Oman is low compared to other western countries indicating the need to initiate a health care transition preparation program for patients with chronic diseases across the country. In addition, we need to establish regional guidelines to address the transitional age policy to be in line to international recommendations.
Evaluation Index System of Surgical Tourism Service Organizations in China: An Empirical Research
Authors: Zhang Dan , Yue Yan , Liao Meixia , Liu Ting-Fang
Published: January 2022

Background: Healthcare tourism is an emerging economy with the most potential in China's health industry before the COVID-19 pandemic. Surgical medical health tourism accounts for a large part of medical tourism services in China, which has higher requirements for quality and safety. By contrast, measurement tools and theoretical research are insufficient in China. The aim of this study was to develop a set of reliable and feasible indicators by augmenting the original Donabedian’s quality model to evaluate surgical tourism services’ quality.Methods: Literature review and focus group interview were used to generate indicators for surgical tourism services’ quality. The basic framework of the evaluation system was based on the structure-process-outcome Donabedian model. The screening and weight setting were conducted through analytic hierarchy process (AHP) and a two-round Delphi consultation with 13 panelists. Validity and reliability of experts were tested by the experts' positive coefficient, authority coefficient, and coordination coefficient. Reliability of the questionnaire was assessed by a pretest distributed within an international medical department of a public hospital in China.Results: Based on the Donabedian’s quality theory, the novel evaluation system of surgical tourism service institutions with 3 dimensions, 9 first-level items and 39 second-level items was constructed. The three dimensions consist of structure (0.315), process (0.287), and outcome (0.398), with each dimension set several indicators and each indicator given a weight. Of the two rounds of Delphi consultation, the response rates were 86.67% and 100%. The coordination coefficient of expert opinions in the two rounds of consultation were 0.49 and 0.65 (p<0.05). For the empirical study, the self-evaluation score of a public hospital was 86, which could obtain a rating of two stars.Conclusions: The established evaluation system identified three different dimensions of surgical tourism services’ quality which fit for practical healthcare improvement in safety and quality. It can reflect the access criterion of surgical tourism institutions, provide references on better choices of surgical services for tourists, and can be applied by healthcare managers and policy makers to allocate resources more efficiently and promote more surgical tourism services to international standards.
Coupling Effects of Goat Manure and Water Management on Immobilization of Cadmium and Improvement of Bacterial Community
Authors: Liu Yiyun , Xu Yingming , Huang Qingqing , Qin Xu , Zhao Lijie , Liang Xuefeng , Wang Lin , Sun Yuebing
Published: January 2022

The objective of this study was to expound possible effect of fertilization and water management in the remediation process of hazardous substance using sepiolite(SP). Meanwhile, Illumina high-throughput sequencing was performed to investigate how the composition of the rhizosphere bacterial community responded to a series of soil remediation process. The results showed that application of SP increased pH, decreased DOM under different water condition, but goat manure (GM) increased pH and DOM at the same time. Under water-saturated condition (FWHC), the application of GM increased the content of available Cd (DTPA-Cd) by 42.0-68.9%, 13.1%-30.3% of unamended and SP-amended soil, respectively. Under normal water condition (NWHC), the application of GM increased DTPA-Cd by 0.7%-5.8%, 73.7%-115.5% of unamended and SP-amended soil, respectively. Consequently, coupling effect of FWHC and GM decreased Cd content in shoots of pak choi. We also found that the application of GM increased the abundance of soil microbial communities. Abundance of proteobacteria reached a peak when applied GM in SP-amended soil under FWHC. RDA analysis showed that soil microbes such as bacteroidetes, patescibacteria, and proteobacteria were correlated positively with pH, DOM, and DTPA-Cd. Acidobacteria was correlated positively with DTPA-Cd, and negatively with pH and DOM. The relationship of soil physicochemical properties and the bacterial community variation indicated that GM and SP mixed additives may indirectly affect the soil microbial community by changing soil physicochemical properties and available Cd content.
Scrambler Therapy for the Treatment of Pain in Schwannomatosis
Authors: Smith Thomas J , Erdek Michael , Murphy Tyler
Published: January 2022

Purpose: Schwannomatosis patients (SP) suffer from chronic nerve pain that is often inadequately relieved. Scrambler Therapy (ST) can relieve neuropathic pain quickly, safely, and inexpensively. We successfully treated a patient with Scrambler Therapy, adding another tool to the methods used to treat SP pain.Methods: We treated her with 5 daily sessions of ST, each for 40 minutes.Results: Complete relief of pain and hyperalgesia, with return to normal function, by day 5, that has persisted.Conclusion: Scrambler Therapy may be an effective way to treat schwannomatosis pain, and deserves further research.
Wave Energy Flux Variability in the Caribbean Sea
Authors: Orejarena Andrés Fernando , Sayol Juan Manuel , Hernández-carrasco Ismael , Cáceres Alejandro , Restrepo Juan Camilo , Orfila Alejandro
Published: January 2022

Wave energy flux (WEF) is assessed in the Caribbean Sea from a 60-year (1958--2017) wave hindcast. We use a novel approach, based on neural networks, to identify coherent regions of similar WEF and their association with different climate patterns. This method allows for a better evaluation of the underlying dynamics behind seasonal and inter-annual WEF variability, including the effect induced by the latitudinal migration of the Intertropical Convergence Zone (ITCZ), and the influence of El Ni\~no-Southern Oscillation events. Results show clear regional differences of the WEF variability likely due to both a clear regionalization of the WEF due to both the intensification and migration of the ITCZ. WEF exhibits a strong semiseasonal signal in areas of the continental shelf, with maximums in January and June, in agreement with the sea surface temperature and sea level pressure variability. At larger scales, WEF shows a significant correlation with the Oceanic Ni\~no Index depicting positive values in the central and western basin and negative ones at the eastern side.
Prenatal and Early Postnatal Exposure to A Natural Disaster and Attention-Deficit/Hyperactivity Disorder Symptoms in Indian Children
Authors: Hanć Tomasz , Gomula Aleksandra , Nowak-Szczepanska Natalia , Chakraborty Raja , Kozieł Sławomir
Published: January 2022

The aim of this study was to assess the relation between early exposure to stressful event and a level of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in children, based on outcomes from a natural experiment. It was hypothesized that children pre- and postnatally exposed to cyclone Aila have a higher level of ADHD symptoms compared to the controls, and the effect depends on timing of exposure. Indian children (8-11y) prenatally (N=336) and early postnatally (N=216) exposed to Aila were compared to non-exposed control group of their peers (N=285). ADHD symptoms were assessed using the Conner’s Teacher Rating Scale Revised. The main effect of exposure to the cyclone on total ADHD symptoms’ score, ADHD index, Hyperactivity and Oppositional symptoms was significant and independent of covariates. Both prenatally and postnatally exposed girls, and only postnatally exposed boys, showed significantly higher level of Oppositional symptoms compared to the controls. Cognitive problems/Inattention symptoms were increased in both prenatally and postnatally exposed boys, but not girls, compared to non-exposed children. The timing of programming the later behavior characteristics by stressful experiences due to natural disaster is not limited to fetal life but extends at least into infancy. Sex is a significant modulator of the early stress-ADHD symptoms association.
Climate Change Scenarios and the Dragon Fruit Climatic Zoning in Brazil
Authors: OLIVEIRA-APARECIDO LUCAS Eduardo , Dutra Alexson Filgueiras , de Lima Rafael Fausto , Neto Francisco de Alcântara , Torsoni Guilherme Botega , Leite Marcos Renan Lima
Published: January 2022

BACKGROUND:The presente paper aims to compute climatological zones apt for the cultivation of pitaya based on trends in the occurrence of climate change events from the IPCC in Brazil. We used temperature and precipitation data from 4,942 cities collected on the NASA / POWER platform from 1990 to 2020 to elaborate on the current scenario. The climate change scenarios were obtained using the CHELSA platform (Climatologies at high resolution for the earth's land surface areas) and corresponded to the periods 2041-2060 and 2061-2080 associated with four IPCC climate change scenarios. The spatialization and interpolation of data occurred according to the aptitude classes designed to meet the thermal and water needs of the crop. RESULTS: Forecasts of increase in temperature indices and reduction in accumulated rainfall were found in all Brazil, but with greater impact in the North and Northeast regions, which had the greatest reduction in areas at low risk for the cultivation of pitaya. In the South and Southeast regions, a large part of the areas remained suitable for the production of this fruit until 2080. CONCLUSION:The results suggest that climate change does not benefit the cultivation of pitaya in some regions of Brazil because the dimensions of the areas apt for economic production be restricted.
WITHDRAWN: Metabolism Of Brain Signals On Human Sleep : a review of mechanisms of action
Authors: Arabestani Alireza N , Ai Arman , Motlagh Nayer Sari , Irvani Sina Naghibi , Arabestanino Mahdi , Jalali Hasti
Published: January 2022

Background
The global research shows that people suffer from a variety of sleep disorders and human actions are the result of neuronal function inside his brain, the feedback of this function can be received and processed as a signal emitted from the surface of the skull. EEG device can receive and record brain signals. Researchers have used a variety of methods to obtain and pre-process signals, extract and reduce the characteristics and types of classifiers in various studies. Research shows that there are three general states of wakefulness (stage 1 + REM sleep) and (stage 2 + deep sleep) separated by the EEG signal.
Methods
The study was performed in accordance with the PRISMA guidelines. A total of 740 articles were found from scientific literature databases (PubMed, Scopus, Web of Science and Wiley Online Library ). After all exclusions, a final total of 64 articles were included in this review. The randomized controlled trials that have assessed at least one therapeutic outcome measured before and after intervention were included in the final analysis.
Results
A total of 64 studies were identified at the screening step. In the identification phase, total of 11 records were excluded from the further assessment and 53 records were entered into the screening phase in which Clinical Trial, Review, Books, Editorial were excluded from the review. In the eligibility stage, 49 records remained in the study where total of 34 studies were included for detailed review. Due to the heterogeneities in the available variables as well as the target aspects, the authors decided to review the studies comprehensively.
Conclusions
However, due to some concerns about its effectiveness, more targeted experiments are needed to identify more accurate targets and pathways responsible for the metabolism of its brain signals.
The material ratio of roadside backfill body based on spatiotemporal law of ground pressure: a case study of Xingtai Mine, China
Authors: Zhao Xinyuan , Li Xinwang , Yang Ke , Cheng Lichao , Qin Yiling
Published: January 2022

The material ratio of the roadside backfill body in gob-side entry retaining determines its mechanical properties, which plays an important role in the supporting effect of the roadway surrounding rock. In this paper, a similar material modeling is used to verify the spatiotemporal law of the ground pressure in the engineering case of dense solid backfilling mining in Xingtai Mine, China. Based on that law, the theoretical requirements for the bearing performance of the roadside backfill body are proposed. Finally, a material ratio that meets the theoretical requirements is obtained by compression test, and the deformation and failure characteristics of the backfill body with this ratio are analyzed. The results show that the maximum pressure of the backfill body measured in Xingtai Mine is 5.5 MPa, which is about 40 m away from the coal face, after 40m, the pressure of the backfill body will not increase anymore. The similar simulation test also proved that the ground pressure behind the coal face increases gradually and tends to be stable during the backfilling process, which shows certain spatiotemporal characteristics. Through the proportioning experiment, it is determined that the optimal material ratio of the roadside backfill body is gangue: fly ash: cement = 10:3:1, which meets the theoretical requirement that the strength of the roadside backfill body at any position is not less than the ground pressure at that position. The research results provide a reference for the engineering practice of gob-side entry retaining in dense backfilling mining.
Stability of Fixed Points in an Approximate Solution of the Spring-Mass Running Model
Authors: Wróblewska Zofia , Płociniczak Łukasz , Kowalczyk Piotr
Published: January 2022

We consider a classical spring-mass model of human running which is built upon an inverted elastic pendulum. Based on our previous results concerning asymptotic solutions for large spring constant (or small angle of attack), we construct analytical approximations of solutions in the considered model. The model itself consists of two sets of differential equations - one set describes the motion of the centre of mass of a runner in contact with the ground (support phase), and the second set describes the phase of no contact with the ground (flight phase). By appropriately concatenating asymptotic solutions for the two phases we are able to reduce the dynamics to a onedimensional apex to apex return map. We find sufficient conditions for this map to have a unique stable fixed point. By numerical continuation of fixed points with respect to energy, we find a transcritical bifurcation in our model system.MSC 2020 Classification: 34C20, 34D05, 37N25, 70K20, 70K42, 70K50, 70K60
Short- and Long-Term Impact of a Multifaceted Approach Targeting Fluoroquinolone use in a Tertiary, Non-Teaching Hospital
Authors: Belsky Brianna , Minson Quentin
Published: January 2022

Background. While various strategies for antibiotic restrictions have been validated, their impacts are not well described in smaller, non-teaching facilities. Fluoroquinolones are an appropriate target for restriction based on their propensity for overuse and potential for causing “collateral damage.” Aim. Evaluate the impact of a multifaceted approach to decreasing fluoroquinolone use on fluoroquinolones and alternative antibiotics at a smaller, non-teaching facility. Method. Retrospective, interrupted time series analysis conducted at a single 288-bed, tertiary, non-teaching hospital with 71 adult ICU beds comparing antibiotic consumption measured monthly by defined daily doses per 1000 adjusted patient days (DDD/1000 APD) prior to intervention (January 2011 to August 2014) to short-term (October 2014 to December 2015) and long-term (January 2018 to December 2019) periods following intervention. Results. An increase in downward trends of fluoroquinolone use was observed from prior to intervention (-0.49 DDD/1000 APD) to the short-term period (-1.13 DDD/1000 APD) and to a greater extent in the long-term period following the intervention (-1.32 DDD/1000 APD). Fluoroquinolone consumption decreased from 100.20 DDD/1000 APD in August 2014 to 73.96 DDD/1000 APD in the short-term and 14.89 DDD/1000 APD in the long-term intervention period. Levofloxacin susceptibility for Pseudomonas aeruginosa increased from 61% in 2014 to 83% in 2018. No deleterious effects on Pseudomonas aeruginosa susceptibilities were observed for alternative antibiotics. Conclusion. A multifaceted approach to decreasing fluoroquinolone use at a smaller, tertiary, non-teaching hospital led to a sustained decrease in consumption and a substantial increase in levofloxacin susceptibility to Pseudomonas aeruginosa.
Clear Cell Carcinoma of the Pancreas Infiltrating Duodenum: A Case Report of a Multiface Aspect of an Intriguing Entity
Authors: Alfano Marie Sophie , Villanacci Vincenzo , Moneghini Dario , Oberti Arianna , Portolani Nazario
Published: January 2022

Background: Although Clear-cell carcinoma has been found in various organs as a variant of ductal carcinoma of the pancreas, it still hasn’t been well recognized. According to the WHO classification, primary Clear-cell carcinoma of the pancreas is rare, and it is classified as a “miscellaneous” carcinoma. To date it has been poorly characterized and only few cases have been reported in the literature [1]. Case presentation: We report here an unusual case of Clear-cell carcinoma in a 59-year-old man involving the head of the pancreas and the second part of the duodenum initially misconceived as pyloric gland adenoma, a rare duodenal entity. Nevertheless, duodenal sub stenosis was suspected of malignancy, so further investigations were made. Subsequent abdominal computed tomography (CT) detected not only a duodenal vegetation but also an alteration of the duodenal-pancreatic interface with thickening of the duodenal wall and a common bile duct dilatation. The malignant clinical aspect and behavior of the lesion, associated to the impossibility of further investigations due to the duodenal sub stenosis, led to an exploratory laparotomy.The laparotomy revealed a retracting area straddling the duodenum and the pancreatic head. A duodenum pancreatectomy of the head of the pancreas with extended lymphadenectomy was performed and the histological evaluation showed a ductal Clear-cell adenocarcinoma of the pancreas infiltrating the duodenum. The postoperative course was characterized by a pancreatic fistula grade B. At 6 months from the surgery, the patient hasn’t had recurrence.Conclusion: Because it is a rare tumor with very few cases reported previously, the incidence and prognosis are not well known for this neoplasm. The report of our case would aid in the identification of this rare neoplasm. Further studies and more case reports are needed to clarify the diagnosis and prognostic significance of the clear cell differentiation of these tumors.
Assessing Spatial Vulnerability of Bangladesh to Climate Change and Extremes: A Geographic Information System Approach
Authors: Azam Md Golam , Rahman Md Mujibor
Published: January 2022

Regarding climate change, the world’s most discussed issue for the last few decades, countries like Bangladesh are always noteworthy due to its susceptibility resulting from its geography, hazard proneness, and socioeconomic condition. Thus, this aimed to justify the hypothesis that Bangladesh has spatial diversity in sectors of Climate Change Vulnerability (CCV) by identifying the sectors of vulnerability and visualizing the spatial distribution of vulnerability through multivariate geospatial analysis in the GIS environment. For an integrated assessment of CCV, 38 indicators (socio-economic and biophysical) have been incorporated in the IPCC framework in raster form. Test statistics have shown Kiser-Meyer-Olkin (KMO) value is 0.73 and the p-value of Bartlett’s sphericity is 0. The principal component analysis resulted in 6 principal components with 73.52% total explained variance. Sectors of CCV are the Climatic extreme event vulnerability (PC1), Meteorological shift vulnerability (PC2), Infrastructure and demographic vulnerability (PC3), Ecological vulnerability (PC4), Flood vulnerability (PC5), and Economic vulnerability (PC6) with Cronbach’s alpha 0.90, 0.81, 0.88, 0.72, 0.72, and 0.66 respectively. Among 3 clusters (Jenk’s Natural break) of weighted averaged indices, the highly vulnerable cluster has shown that the PC1 has the highest magnitude with a score of 0.53–0.87, while the PC5 has the highest spatial coverage with 24 districts. The present study however is a new edition in climate vulnerability assessment in Bangladesh since it encompasses multivariate spatial analysis to demonstrate countrywide CCV. This study should be an important tool for setting adaptation and mitigation strategies from the root level to policymaking platforms of Bangladesh.
ReactiveFnJ: A Choreographed Model for Fork-Join Workflow in Serverless Computing
Authors: Bharti Urmil , Goel Anita , Gupta S. C.
Published: January 2022

Function-as-a-Service (FaaS) is an event-based reactive programming model where functions run in ephemeral stateless containers for short duration. For building complex serverless applications, function composition is crucial to coordinate and synchronize the workflow of an application. Some serverless orchestration systems exist, but they are in their primitive state and do not provide inherent support for non-trivial workflows like, Fork-Join. To address this gap, we propose a fully serverless and scalable design model ReactiveFnJ for Fork-Join workflow. The intent of this work is to illustrate a design which is completely choreographed, reactive, asynchronous, and represents a dynamic composition model for serverless applications. Our design uses two innovative patterns, namely, Relay Composition and Master-Worker Composition to solve execution time-out challenges. As a Proof-of-Concept (PoC), the prototypical implementation of Split-Sort-Merge use case, based on Fork-Join workflow is discussed and evaluated. The ReactiveFnJ handles embarrassingly parallel computations, and its design does not depend on any external orchestration services, messaging services, and queue services. ReactiveFnJ facilitates in designing fully automated pipelines for distributed data processing systems, satisfying the Serverless Trilemma in true essence. A file of any size can be processed using our effective and extensible design without facing execution time-out challenges. The proposed model is generic and can be applied to a wide range of serverless applications that are based on the Fork-Join workflow pattern. It fosters the choreographed serverless composition for complex workflows. The proposed design model is useful for software engineers and developers in industry and commercial organizations, total solution vendors and academic researchers.
Impact of feed supplementation with balsam poplar buds on performance of young bulls
Authors: Balji Yu. , Knicky M.
Published: January 2022

There is an urgent need to develop new strategies to minimize the environmental impact of animal production and support sustainability of food production and consumption. Feed additives have been for a long time used in animal nutrition to improve animal growth and performance as well as animal health. Balsam poplar plants (Populus balsamifera) is well known as a rich source of bioactive compounds with positive health effects, and might be used in agriculture as a feed additive for ruminants. The aim of the present study was to evaluate the effect of balsam poplar-based additives on growth and performance of fattening young bulls of Simmental breed. In the present study, we used 4 combinations of extract from balsam poplar buds or its components as a feed additives. The animals were given the supplements at the age of 15 months, 3 months before slaughter. The growth and slaughter characteristics of young bulls were studied. After the first and second month of feeding with dietary supplements, animals from the groups fed 10% balsam poplar buds extract and dry shredded balsam poplar buds had significantly higher live weight compared to the control animals fed a diet without any supplements (P < 0.05). At slaughter, group fed 10% balsam poplar buds extract had significantly higher live weight compared to control. Average daily gain was also greatest in that group. Major sensory as well as physical and chemical parameters were not affected by balsam poplar-based supplements (p > 0.05 for all) and were in line with regulatory meat hygiene requirements.
Comparative proteomic study of pig muscle proteins during growth and development of an animal
Authors: Akhremko A. G. , Vetrova E. S.
Published: January 2022

The production of high-quality pork is closely related to the growth and development of muscle tissue. The present article provides a comparative proteomic research of l. dorsi, b. femoris, m. brachiocephalicus during the pigs’ growth and development (at age of 60 days and 180 days). This work was supported by data of electrophoretic methods: one-dimensional electrophoresis according to Laemmli with densitometric assessment in the ImageJ software and two-dimensional electrophoresis according to O’Farrell method with its further processing on the software ImageMaster. The mass spectrometric identification was conducted with the help of the high-performance liquid chromatography (HPLC) system connected to a mass spectrometer; further the data were interpreted by search algorithm Andromeda. When comparing frequency diagrams of one-dimensional electrophoregrams of all three muscle tissues of weaned pigs, the greatest difference was observed for the muscle sample l. dorsi. Comparison of diagrams of muscle tissue samples taken for mature pigs showed a great similarity of all three studied muscles samples. Within the framework of the research, the Fold indicator was calculated. The exceeding its value by more than 2 units is generally considered to be a statistically significant difference. When analyzing two-dimensional electrophoretograms of weaned pigs’ muscles, 18 protein fractions were revealed with Fold > 2. When examining the muscle tissue of mature pigs, 15 of those proteins were found; the differences were mostly detected in the minor protein fractions. The mass spectrometric analysis of the cut bands with well-pronounced differences from the onedimensional electrophoretogram revealed 214 proteins involved to a greater extent in cellular and metabolic processes, physical activity and localization. Growth and development protein — semaphorin‑6B (96.78 kDa) — was revealed in muscle tissue of l. dorsi, a. Also in l. dorsi and b. femoris the growth and development proteins were found: cadherin‑13 (78.23 kDa), cadherin‑7 (87.01 kDa), the F‑actin-cap protein beta subunit (30.66 kDa), and two uncharacterized proteins at 65.60 kDa and 63.88 kDa.
Analysis of the efficiency of production of whole-muscle turkey products with vegetable sprinkles
Authors: Gorlov I. E. , Bozhkova S. E. , Nichiporova A. R. , Danilov Y. D. , Slozhenkina M. I. , Romanenko E. A.
Published: January 2022

Human health is largely determined by the nature, level and structure of nutrition. A promising direction in the development of new food products is the expansion of the base of used ingredients used to partially replace meat raw materials with vegetable ones, in order to maximize the saturation of products with nutrients that contribute to the maintenance of normal life of the consumer. The use of new food ingredients contributes to the actual task set by the State policy in the field of healthy eating — expanding the range of enriched and functional food products. The work is devoted to the study of baked whole-muscle products using turkey meat and vegetable dressing as sources of high protein content, which solves the problem of deficiency of this component in the diet. A recipe for brine with the addition of the food additive “Glimalask”, which has a complex effect on the products under study, has been presented. The evaluation of quality indicators of finished products has been carried out, the article presents the results of a comparative analysis of baked whole-muscle turkey meat products, calculations of the product cost price. The comparative analysis has shown that, in comparison with the control sample, the baked whole-muscle products from turkey meat with vegetative dressing have improved physical and chemical properties, outstanding organoleptic characteristics, the yield of the product increases by 9.0–12.0%, depending on the formulation. Differences in the dynamics of microbial growth in the experimental and control samples were insignificant, the vegetable dressing helps to slow the growth of microorganisms on the surface of the product. The presented baked whole-muscle turkey meat products using optimized brine and vegetable sprinkles of chickpeas, sesame and paprika are recommended to a wide range of consumers of different age groups.
New application of microbial l-glutaminase as a flavor enhancing agent in beef burgers
Authors: Mohamed R. M. , Bazaraa W. A. , Alian A. M. , EL-Shimi N. M.
Published: January 2022

L‑glutaminase (L‑glutamine amidohydrolase EC3.5.1.2) is the key enzyme in enhancing the taste and aroma of oriental fermented foods by increasing their glutamic acid content and as a result imparting a palatable taste. Beef burgers were prepared using different levels of the partially purified L- glutaminase (2.0 to10.0 U/100 g) prepared from Aspergillus oryzae NRRL 32567. Beef burgers treated with 6.0 U/100g and the others treated with monosodium glutamate (5000 ppm) were chemically, sensory and microbiologically evaluated and compared to untreated control during frozen storage at –18 ºC for 3 months. Treatment with L‑glutaminase (6 U/100g) resulted in an increase of 443% in glutamic acid and a reduction of 63% in glutamine contents resulting in an enhanced preferable taste and odor of the prepared beef burgers. Burgers treated with 6.0 U/100g exhibited the best odor, texture, taste and overall quality scores when compared to the untreated control and samples treated with monosodium glutamate (5000 ppm). During the frozen storage of all samples, an expected slight, but significant (p≤0.05), increase in the total mesophilic bacterial count was evident and such increase was quite acceptable since numbers did not exceed the limit of 5.7x103 cfu/g. Similarly, the total psychrotrophs did not exceed 3.7x102 cfu/g.
A Study of QCD Radiation in VBF Higgs Production with Vincia and Pythia
Authors: Höche Stefan , Mrenna Stephen , Payne Shay , Preuss Christian Tobias , Skands Peter
Published: January 2022

We discuss and illustrate the properties of several parton-shower algorithms available in Pythia and Vincia, in the context of Higgs production via vector boson fusion (VBF).
In particular, the distinctive colour topology of VBF processes allows to define observables sensitive to the coherent radiation pattern of additional jets.
We study a set of such observables, using the Vincia sector-antenna shower as our main reference, and contrast it to Pythia's transverse-momentum-ordered DGLAP shower as well as Pythia's dipole-improved shower. We then investigate the robustness of these predictions as successive levels of higher-order perturbative matrix elements are incorporated, including next-to-leading-order matched and tree-level merged calculations, using Powheg Box and Sherpa respectively to generate the hard events.
Онтологические регуляторы личности в системе образования
Authors: Малиновский Е.Л.
Published: January 2022

Понимание неопределенности цели, при знаковом опо- средовании развития высших психических функций субъекта, предполагает патерналистскую инициативу личностной ответ- ственности, при которой академический либерализм Болонского процесса, приобретает онтологическую направленность знания: «Познаете истину и истина сделает вас свободными» [Ин 8:32].
Проблема оценки качества образовательного процесса в Российской Федерации в условиях инклюзии
Authors: Дормидонтов Р.А. , Елисеев В.К. , Меремьянина А.И.
Published: January 2022

В статье представлен анализ систем оценки качества реализации инклюзивного образования в общеобразовательных организациях Российской Федерации.
Образовательные потребности и профориентационная работа с абитуриентами с инвалидностью и ограниченными возможностями здоровья в медицинском вузе
Authors: Колесникова И.Ю. , Самоукина А.М. , Иванов А.Г. , Мсхвилидзе Н.П. , Григорьева Д.Д.
Published: January 2022

Абитуриенты с инвалидностью чаще нуждаются в консультациях сотрудников приемной комиссии и психологов. Они более уверены в своем выборе будущей профессии. Особые образовательные потребности – со- циально-психологическое сопровождение, помощь тьютора, адаптация образовательных программ. Здоровые поступающие и абитуриенты с инвалидностью высказались за совместное аудиторное обучение.
Water quality prediction based on Naïve Bayes algorithm
Authors: Ilić M. , Srdjević Z. , Srdjević B.
Published: January 2022

In the fast-changing world with increased water demand, water pollution, environmental problems, and related data, information on water quality and suitability for any purpose should be prompt and reliable. Traditional approaches often fail in the attempt to predict water quality classes and new ones are needed to handle a large amount or missing data to predict water quality in real time. One of such approaches is machine-learning (ML) based prediction. This paper presents the results of the application of the Naïve Bayes, a widely used ML method, in creating the prediction model. The proposed model is based on nine water quality parameters: temperature, pH value, electrical conductivity, oxygen saturation, biological oxygen demand, suspended solids, nitrogen oxides, orthophosphates, and ammonium. It is created in Netica software and tested and verified using data covering the period 2013–2019 from five locations in Vojvodina Province, Serbia. Forty-eight samples were used to train the model. Once trained, the Naïve Bayes model correctly predicted the class of water sample in 64 out of 68 cases, including cases with missing data. This recommends it as a trustful tool in the transition from traditional to digital water management.
Spatiotemporal modeling of water inrush spreading in mine roadway networks
Authors: Zhang Xiaoyan , Wu Qiang , Zhao Yingwang , Liu Shouqiang , Xu Hua
Published: January 2022

Water inrush accidents seriously threaten underground mining production, so the accurate prediction of the spreading process of water inrush is essential for the formulation of water-inrush-control plans and rescue schemes. This paper proposes a spatiotemporal model based on pipe-flow theory to simulate the spreading process of water inrush in mine roadway networks. The energy-loss term is added to this model to improve the simulation accuracy in bifurcated roadways, and pumps and water-blocking equipment are considered in controlling the spreading process of water inrush. Through experimental case studies, the simulation results and the function of the energy-loss term are verified. A sensitivity analysis is then carried out to assess the impact of the model parameters. The results show that the model outputs are most sensitive to the roadway length, cross-section width, and energy-loss coefficient. The model exhibited maximal sensitivity to the geometric parameters compared with the hydraulic parameters. Furthermore, the spreading process of a real water inrush in a coal mine in North China is simulated, and the water-inrush-control measures are evaluated. The overall results indicate that the proposed spatiotemporal model accurately predicts the spreading process of water inrush and is thus applicable to large-scale mine roadway networks.
PODŻEGANIE NA GRUNCIE POLSKIEGO PRAWA KARNEGO
Authors: Kruk Rafał
Published: January 2022

Artykuł ten dotyczy problematyki podżegania jako formy zjawiskowej czynu zabronionego na gruncie regulacji obowiązującego kodeksu karnego z 1997 r. Autor dokonuje kompleksowej analizy znamion podżegania na tle pozostałych postaci zjawiskowych oraz przedstawia ogólne koncepcje odpowiedzialności za przestępcze współdziałanie, ze szczególnym uwzględnieniem teorii Juliusza Makarewicza. Ponadto w artykule poruszone zostały zagadnienia związane z podżeganiem, które budzą największe rozbieżności i kontrowersje w doktrynie oraz orzecznictwie. Struktura tekstu obejmuje w pierwszej kolejności przedstawienie sprawczych postaci współdziałania, uregulowanych w art. 18 § 1 k.k., a więc jednosprawstwa, współsprawstwa, sprawstwa kierowniczego i sprawstwa polegającego na wydaniu polecenia. Analizie poddane zostało również pomocnictwo jako forma zjawiskowa mająca, w odróżnieniu, niesprawczy charakter. Zasadnicza część artykułu obejmuje zagadnienie podżegania jako odrębnego czynu zabronionego, w tym przede wszystkim kompleksowe omówienie wszystkich elementów strony przedmiotowej i podmiotowej tego czynu zabronionego. Niezostały pominięte także kwestie związane z wymiarem kary dla podżegacza. Autor skupił się również na ważkiej problematyce „krzyżowania się” podżegania z formami stadialnymi czynu zabronionego.
Influência da vazão de injeção sobre a uniformização do perfil de fluxo em poços horizontais
Authors: Silva Mantegazini Isabela , Romero Oldrich Joel
Published: January 2022

Perfis de fluxo não uniformes causados pela perda de pressão no interior de poços horizontais injetores diminuem a injetividade e a eficiência de varrido. Dada a preocupação das empresas em aumentar da recuperação final, diversas técnicas para uniformização de fluxo foram desenvolvidas, dentre elas está a furação diversiva, que consiste na distribuição diferenciada dos furos no liner de completação. Este estudo objetiva ilustrar o funcionamento da técnica de furação diversiva e analisar a influência da vazão de injeção sobre a perda de pressão assim como sobre o perfil de fluxo em poços horizontais. Os resultados obtidos mediante simulação numérica com auxílio do software Fluent, demostram que o perfil de fluxo acompanha o comportamento da perda de carga no interior da tubulação, e que uma maior vazão de injeção resulta em uma saída de fluido pelos furos mais uniforme e por consequência mais eficiente, conforme proposto pela técnica de furação diversiva.