bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Magnetic Markers for the Diagnostics of Conveyor Belt Transportation Systems
Authors: Semrád Karol , Draganová Katarína
Published: May 2023

Together with the research and development of belt conveyors, diagnostic methods for their reliable operation have been developed. Our research is focused on the development of a diagnostic system and method of sensing the magnetic markers implemented directly into the conveyor belt, as in this way, it is possible to determine the velocity of the conveyor belt, which can be a source of information about the potential malfunction of the drive unit, control system, or of the belt itself. The magnetic markers can be also used to mark the particular segments of the conveyor belt, which can significantly enhance maintenance procedures thanks to the identification of damaged segments and the possibility to stop the conveyor belt in the maintenance area. However, problems can occur with the implementation of the magnetic markers. To prevent the magnetic markers from falling out, FEM (finite element method) simulations and analyses of commercially available magnetic markers with different dimensions were performed to analyze the nominal and friction force and related average contact pressure acting on the magnetic markers implemented into holes drilled into the conveyor belt in the curved state when passing through the drum.
Calculating and Analyzing Carbon Emission Factors of Prefabricated Components
Authors: Yu Lei , Wang Yang , Li Dezhi
Published: May 2023

The construction industry’s carbon emissions have a considerable impact on the environment, and all countries have pledged to reduce them to achieve low-carbon transformation. The use of prefabricated components is widely recognized as a crucial measure for mitigating carbon emissions. However, there is a scarcity of existing data on the carbon emission factors of prefabricated components (CEFoPC), and few studies have focused on calculating and reducing their carbon emissions. This study presents a novel approach to calculating CEFoPC, which involves analyzing the production process, defining the carbon emission range, identifying the sources of carbon emissions, and establishing measurement equations for the carbon emissions of prefabricated components. The proposed approach is demonstrated using six typical prefabricated components in Nanjing, China, namely, prefabricated exterior and interior wall panels, stairs, laminated panels, balconies, and air conditioning panels. After decomposing the carbon emission factors and exploring carbon emission reduction strategies, the findings suggest that the production and transportation of raw materials are the primary contributors to carbon emissions associated with prefabricated components. Additionally, the most effective carbon emission reduction strategy involves the use of green and recycled raw materials. Furthermore, the framework for calculating CEFoPC proposed in this study is considered a significant contribution, as it can facilitate future research and the enrichment of carbon emission factor databases.
Construction of Nature Reserves’ Ecological Security Pattern Based on Landscape Ecological Risk Assessment: A Case Study of Garze Tibetan Autonomous Prefecture, China
Authors: Ju Lingfan , Liu Yan , Yang Jin , Xiang Mingshun , Xiang Qing , Hu Wenkai , Ding Zhengyi
Published: May 2023

Human activities are constantly affecting ecological space, and the construction of ecological security patterns to ensure ecological security has become an issue that must be considered for sustainable development. At present, little attention has been paid to the ecological security of cities with a high number of nature reserves. In this study, we took Garze Tibetan Autonomous Prefecture in China, which has many nature reserves, as the research object to construct an ecological security pattern with nature reserves as ecological sources. Firstly, Fragstats 4.2 and ArcGIS 10.4 were used to obtain the ecological risk evaluation results of the study area landscape. Secondly, a “nature–society–landscape” resistance factor system and an ecological resistance surface were constructed using a minimum resistance model. Finally, the ecological safety zone of the nature reserve was divided, and the ecological safety pattern of the nature reserve was established. (1) The ecological risk of the study area shows a spatial distribution pattern of “low in the northwest and high in the southeast”, with low and moderate-low ecological risk dominating; (2) The study area has formed an ecological security pattern consisting of 9 ecological sources, 35 ecological nodes, 8 ecological corridors with a total length of 702.96 km and 4 ecological safety zones; (3) The ecological security pattern of nature reserves in the study area was divided into four categories: low, medium, high and moderate-high ecological safety zones, accounting for 20.62%, 27.34%, 24.48% and 27.55%, respectively. This study provides a new framework for the construction of urban ecological safety patterns and offers scientific guidance for the conservation and management of nature reserves and urban ecology.
Enhancing Students’ Entrepreneurial Competencies through Extracurricular Activities—A Pragmatic Approach to Sustainability-Oriented Higher Education
Authors: Isac Claudia , Iordache Ana Maria Mihaela , Baltador Lia , Coculescu Cristina , Niță Dorina
Published: May 2023

Entrepreneurship can provide a creative, disruptive, problem-solving-oriented approach to the current economic, environmental, and social challenges of the world. This article aims to provide an analysis about the way universities can have an impact on developing entrepreneurial competence in students through extracurricular activities. The research relies on a questionnaire survey of students at the University of Petrosani, who participated in a range of entrepreneurial activities both online during the COVID-19 pandemic and face-to-face afterwards. The methodology consisted of applying principal component analysis to reduce the dimensionality of the indicators, followed by classification of the respondents through cluster analysis and training of a feedforward neural network. After finishing the network-training process, the error was minimized, resulting in three classes of respondents. Furthermore, based on the three classes, follow-up conclusions, policies, and decisions can be issued regarding the perception of entrepreneurship at the societal level, which is beneficial for academia and entrepreneurs, as well as for future research undertaken in this field. The key conclusion of our research is that entrepreneurship education is a real facilitator of the transition to sustainable entrepreneurship. Students perceived meeting successful entrepreneurs as being among the most effective extracurricular activities, assessing online activities as useful, and the field of study proved to be an important factor in their entrepreneurial intention.
Quantifying the Potential Co-Benefit of Air Quality Improvement on Cultural Heritage in China
Authors: Wang Ximo , Li Huimin , Wang Yufei , Zhao Xiaofan
Published: May 2023

Atmospheric pollutants can corrode heritage materials, especially stone, which can cause a great loss that goes far beyond the economic losses of the degraded materials. Over the past decades, conventional air pollutants have been slashed owing to clean air actions in China, which produces a significant co-benefit for heritage conservation. However, the benefits may be offset by increases in the photochemical oxidants in smog, such as ozone, which damage heritage materials. This study employed dose–response functions to quantify the impacts of air pollutants on the surface recession of the limestone of heritage structures in China, and assessed the potential benefits of air quality improvement for heritage conservation. The results show that the annual recession rate decreased from 9.69 μmy−1 in 2006 to 6.71 μmy−1 in 2020, resulting in a 41.4% increase in the number of heritage sites meeting the ICP Materials (International Co-operative Program on Effects on Materials including Historic and Cultural Monuments) control target of 8 µmy−1 for 2020. The air quality improvement avoided CNY 136.2 million in heritage site maintenance costs. The recession risk shows distinct regional differences; the southern and northwest regions are still at a higher material corrosion level than the northern and Qinghai–Tibet regions. Nationwide, PM10 (particles with aerodynamic diameter less than 10 μm) is the main risk factor responsible for the surface recession of limestone material of heritage structures in China. The study provides evidence for the benefits of air quality improvement for heritage conservation. Further, the study also puts forward policy recommendations for heritage conservation, including assessing pollution risk, promoting heritage conservation through social sustainability, and implementing differentiated conservation strategies.
Exploring Influential Factors of Free-Floating Bike-Sharing Usage Frequency before and after COVID-19
Authors: Xie Xinyi , Du Mingyang , Li Xuefeng , Jiang Yunjian
Published: May 2023

In order to better understand the impact of COVID-19 on the free-floating bike-sharing (FFBS) system and the potential role of FFBS played in the pandemic period, this study explores the impact mechanism of travel frequency of FFBS users before and after the pandemic. Using the online questionnaire collected in Nanjing, China, we first analyze the changes of travel frequency, travel distance, and travel duration in these two periods. Then, two ordered logit models are applied to explore the contributing factors of the weekly trip frequency of FFBS users before and after COVID-19. The results show that: (1) While the overall travel duration and travel distance of FFBS users decreased after the pandemic, the trip frequency of FFBS users increased as the travel duration increased. (2) Since COVID-19, attitude perception variables of the comfort level and the low travel price have had significantly positive impacts on the weekly trip frequency of FFBS users. (3) Respondents who use FFBS as a substitution for public transport are more likely to travel frequently in a week after the outbreak of COVID-19. (4) The travel time in off-peak hours of working days, weekends, and holidays has a significantly positive correlation with the trip frequency of FFBS users. Finally, several relevant policy recommendations and management strategies are proposed for the operation and development of FFBS during the similar disruptive public health crisis.
Competitiveness of and Barriers to Indonesia’s Exports of Ornamental Fish
Authors: Tarihoran Andiga Dompak Baharaja , Hubeis Musa , Jahroh Siti , Zulbainarni Nimmi
Published: May 2023

Indonesia has been striving to become the world’s largest ornamental fish exporter for the past two decades, but success has been limited. This study analyzes Indonesia’s export competitiveness and identifies the barriers encountered. A trade analysis using the UN-Comtrade database for 2012–2021 was conducted using the Revealed Comparative Advantage (RCA), Constant Market Shares (CMS), and Competitiveness Matrix formulas to evaluate the competitiveness. Qualitative data from interviews with forty-three industry stakeholders were analyzed using NVivo to evaluate export barriers. The findings revealed that Indonesia had not been optimally exporting to some of the world’s largest markets and faced various barriers, such as product quality and continuity, regulations, marketing, shipment, and other internal and external barriers. The government’s role in overcoming those barriers is crucial while maintaining environmental sustainability. We also propose a matrix model for export barrier levels consisting of export readiness, export market accessibility, export operational challenges, and dynamic export environment.
Study on Rock and Surface Subsidence Laws of Super-High Water Material Backfilling and Mining Technology: A Case Study in Hengjian Coal Mine
Authors: Li Ming , Yan Yueguan , Dai Huayang , Zhang Zhaojiang
Published: May 2023

Research on the rock and surface subsidence laws of super-high water material backfilling and mining technology can provide a scientific basis for liberating coal resources that are deposited under buildings, railways, and bodies of water. Using field measurements, numerical simulations, and theoretical analyses to study the geological mining conditions of the Hengjian Mine in Handan, Hebei Province, this research comprehensively analyzes the dynamic and static deformation laws of rock and surface subsidence, reveals the subsidence control mechanism, complements existing studies and helps improve the feasibility of new technology in engineering practices. This study shows that rock and surface subsidence values are smaller when the super-high water material backfilling and mining technology are used, and the surface movement parameters are smaller than those of the fully caving mining method. The backfilling material supports the rock load above the mining area and suppresses the rock and surface subsidence. In addition, the super-high water backfilling material limits the height of the developing stress arch above the mining area, thus reducing the range of deformation in the rock and surface movement. In engineering practice, the development of the stress arch can be controlled by increasing the backfilling rate and the strength of the backfilling material. With the above-mentioned discoveries, this research is of great significance to the promotion and application of super-high water material backfilling and mining technology and the liberation of deposited coal resources.
Determination of Pesticide Residues in Olive Oil Using QuEChERS Extraction and Liquid Chromatography–Orbitrap High-Resolution Mass Spectrometry: Comparison of Different Clean-Up Sorbents and Validation Study
Authors: Iosif Konstantina , Konstantinou Ioannis
Published: May 2023

The aim of this study was the optimization of the clean–up step in the widely applied QuEChERS method for the determination of 39 representative multiclass pesticides in olive oil with Ultra-High-Performance Chromatography–Orbitrap Mass Spectrometry (UHPLC-Orbitrap-MS). The analytical methodology combines the original version of QuEChERS extraction with two different clean-up-step approaches, using firstly a combination of Z-Sep+, PSA and MgSO4 and secondly EMR-lipid. The methods were compared for their efficiency in the removal of fats and co-extractives and their effect on the analytical performance characteristics. Both methods were evaluated in terms of linearity, matrix effects (ME), recovery, precision, limits of detection (LOD) and quantification (LOQ) and expanded uncertainty in three spiking levels of 30, 100 and 300 μg/kg. The recoveries ranged between 70–113% for 95% of analytes (RSDr < 14%) when EMR-lipid was used as a sorbent, while in the case of Z-Sep+/PSA/MgSO4 recoveries ranged between 72–107% for 92% of analytes (RSDr < 18%). ME showed low signal suppression for 77% of analytes in the case of Z-Sep+/PSA/MgSO4 and for 85% of analytes in the case of EMR-lipid. According to the results, both methodologies provided good analytical performances fulfilling validation criteria; however, the EMR-lipid sorbent showed better clean-up capacity (i.e., less matrix effects and lower variability in extraction recoveries) and validation parameter values for more analytes. The validated method was successfully applied to 30 olive oil samples from different regions of Greece. No residues have been identified in the analyzed samples.
Optimal Scheduling of AC–DC Hybrid Distribution Network Considering the Control Mode of a Converter Station
Authors: Tang Xu , Qin Liang , Yang Zhichun , He Xiangling , Min Huaidong , Zhou Sihan , Liu Kaipei
Published: May 2023

Due to the difference in types of loads between regions and the increasing integration of random elements such as electric vehicles (EVs) and distributed generations (DGs), distribution station areas (DSAs) are facing challenges such as unbalanced load rates and voltage violations. An AC–DC hybrid distribution network formed by interconnecting AC-DSAs using flexible DC technology can not only address these issues, but also offer more efficient interfaces for EV charging piles and DC devices on the DC side. To fully leverage the advantages of the technology and coordinate dispatchable elements within each DSA, this paper proposes an optimal scheduling model, which balances the load rate between DSAs, improves voltage profiles, and considers the control mode of the converter station as a dispatchable element, taking into account its impact on the voltage deviation on the DC side. Simulation results demonstrate the effectiveness of the proposed model in balancing load rate and improving voltage profiles. Moreover, rational decision-making regarding the selection of the control mode for converter stations can effectively mitigate the voltage deviation on the DC side without deteriorating the voltage deviation on the AC side.
A Review on the Characterization and Measurement of the Carbonaceous Fraction of Particulate Matter
Authors: Correa-Ochoa Mauricio A. , Bedoya Roxana , Gómez Luisa M. , Aguiar David , Palacio-Tobón Carlos A. , Colorado Henry A.
Published: May 2023

The carbonaceous particles represent a significant fraction in the particulate matter (PM) and are considered an environmental hazard due to their effects on climate and health. The main goal in this research is to identify and analyze the scope that have been achieved so far on the characterization and measurement of the carbonaceous fraction present in PM, a great contribution to global pollution and thus to the deterioration of public health. The ProKnow-C methodology was used to build a bibliographic portfolio and perform a bibliometric and systemic analysis of the information found in the chosen databases. The contribution of these carbonaceous compounds to PM is very significant, reaching values up to 50%. The most used methods for the determination of organic and elemental carbon are thermo-optical reflectance and transmittance. Positive Factorization models are used worldwide to determine potential sources of particulate matter emissions. Even though various studies have been developed to understand these carbonaceous substances, there are several limitations in the measurements and limited knowledge on the subject. The positive outcomes and future possibilities were analyzed as well.
Salt Cavern Thermal Damage Evolution Investigation Based on a Hybrid Continuum-Discrete Coupled Modeling
Authors: Feng Kai , Li Wenjing , Nan Xing , Yang Guangzhi
Published: May 2023

The integrity and stability of salt caverns for natural gas storage are subjected to a gas cycling loading operation. The coupled effect of confining pressure and temperature on the response of the salt cavity surrounding the wall is essential to stability analysis. In this study, a hybrid continuum-discrete model accounting for the thermal-mechanical process is proposed to investigate the thermal-damage evolution mechanism towards a field case with blocks falling off the salt cavity. The salt cavity is modeled by continuum zones, and the potential damage zones are simulated by discrete particles. Three specimens at different locations around the surrounding wall are compared in the context of severe depressurization. The dynamic responses of rock salt, including temperature spatiotemporal variation, microscopic cracking patterns, and energy evolution exhibit spatial and confinement dependence. A series of numerical simulations were conducted to study the influence of microproperties and thermal properties. It is shown that the evolution of cracks is controlled by (1) the thermal-mechanical process (i.e., depressurization and retention at low pressure) and (2) the anomalous zone close to the brim of the salt cavity surrounding the wall. The zone far away from the marginal surrounding wall is less affected by temperature, and only the mechanical conditions control the development of cracks. This continuum/discontinuum approach provides an alternative method to investigate the progressive thermal damage and its microscopic mechanism.
The Relationships between University Students’ Physical Activity Needs, Involvement, Flow Experience and Sustainable Well-Being in the Post-Pandemic Era
Authors: Liao Chen , Nong Liying , Wu Yu-Feng , Wu Yu-Tai , Ye Jian-Hong
Published: May 2023

As the global sustainable development agenda advances, having a healthy lifestyle has become an important part of the common pursuit. Physical activity needs and experiences are becoming increasingly diverse, yet there is a paucity of research on issues associated with university students’ physical activity needs, and their perceptions of their physical activity needs and sustainable well-being are not yet fully understood. Therefore, this study combines Self-Determination Theory with the existence, relatedness, and growth (ERG) Theory of Needs to explore the mediating effects of different variables on the relationship between university students’ physical activity needs and sustainable well-being. A total of 900 Chinese university students were invited through an online survey to participate in this study, and the collected data were validated with a structural equation model. According to the results of the study, it was found that the level of involvement and flow experience in university students’ sports activities have a mediating effect on the relationship between needs and sustainable well-being. Therefore, educators can enhance the level of sustainable well-being by stimulating university students’ physical activity needs and improving their level of involvement and participation experience.
Spontaneous Soft Tissue Hematomas in Patients with Coagulation Impairment: Safety and Efficacy of Transarterial Embolization
Authors: Fior Davide , Di Provvido Stefano , Leni Davide , Corso Rocco , Moramarco Lorenzo Paolo , Pileri Matteo , Grasso Rosario Francesco , Santucci Domiziana , Faiella Eliodoro
Published: May 2023

The aim of this study is to report the authors’ experience of percutaneous transarterial embolization (TAE) in patients with spontaneous soft tissue hematomas (SSTH) and active bleeding with anticoagulation impairment. The study retrospectively identified 78 patients who received a diagnosis of SSTH by CT scan and underwent TAE between 2010 and 2019 in a single trauma center. The patients were stratified using Popov classification into categories: 2A, 2B, 2C, and 3. The patient’s 30-day survival after TAE was considered the primary outcome; immediate technical success, the need for additional TAE, and TAE-related complications were considered secondary outcomes. Immediate technical success, complication rate, and risk factors for death were analyzed. Follow-up stopped on day 30 from TAE. 27 patients (35%) fell into category 2A, 8 (10%) into category 2B, 4 (5%) into category 2C, and 39 (50%) into category 3. Immediate technical success was achieved in 77 patients (98.7%). Complications included damage at the arterial puncture site (2 patients, 2.5%) and acute kidney injury (24 patients, 31%). Only 2 patients (2.5%) had been discharged with a new diagnosis of chronic kidney disease. The 30-day overall mortality rate was 19% (15 patients). The mortality rate was higher in hemodynamically unstable patients, in Popov categories 2B, 2C, and 3, and in patients with an initial eGFR < 30 mL/min × 1.73 m2. The study demonstrated a higher mortality risk for categories 2B, 2C, and 3 compared to category 2A. Nonetheless, TAE has proven effective and safe in type 2A patients. Even though it is unclear whether type 2A patients could benefit from conservative treatment rather than TAE, in the authors’ opinion, a TAE endovascular approach should be promptly considered for all patients in ACT with active bleeding demonstrated on CT scans.
Association between Residential Exposure to Air Pollution and Incident Coronary Heart Disease Is Not Mediated by Leukocyte Telomere Length: A UK Biobank Study
Authors: Kuo Chia-Ling , Liu Rui , Godoy Lucas da Cunha , Pilling Luke C. , Fortinsky Richard H. , Brugge Doug
Published: May 2023

Higher air pollution exposure and shorter leukocyte telomere length (LTL) are both associated with increased risk of coronary heart disease (CHD), and share plausible mechanisms, including inflammation. LTL may serve as a biomarker of air pollution exposure and may be intervened with to reduce the risk of CHD. To the best of our knowledge, we are the first to test the mediation effect of LTL in the relationship between air pollution exposure and incident CHD. Using the UK Biobank (UKB) data (n = 317,601), we conducted a prospective study linking residential air pollution exposure (PM2.5, PM10, NO2, NOx) and LTL to incident CHD during a mean follow-up of 12.6 years. Cox proportional hazards models and generalized additive models with penalized spline functions were used to model the associations of pollutant concentrations and LTL with incident CHD. We found non-linear associations of air pollution exposure with LTL and CHD. Pollutant concentrations in the lower range were decreasingly associated with longer LTL and reduced risk of CHD. The associations between lower pollutant concentrations and reduced risk of CHD, however, were minimally mediated by LTL (<3%). Our findings suggest that air pollution influences CHD through pathways that do not involve LTL. Replication is needed with improved measurements of air pollution that more accurately assesses personal exposure.
Factors Affecting the Adsorption of Heavy Metals by Microplastics and Their Toxic Effects on Fish
Authors: Chen Qianqian , Zhao Haiyang , Liu Yinai , Jin Libo , Peng Renyi
Published: May 2023

Fish not only constitute an important trophic level in aquatic ecosystems but also serve as an important source of protein for human beings. The health of fish is related to the sustained and healthy development of their entire aquatic ecosystem. Due to the widespread use, mass production, high disposal frequency, and degradation resistance of plastics, these pollutants are released into aquatic environments on a large scale. They have become one of the fastest growing pollutants and have a substantial toxic effect on fish. Microplastics have intrinsic toxicity and can absorb heavy metals discharged into water. The adsorption of heavy metals onto microplastics in aquatic environments is affected by many factors and serves as a convenient way for heavy metals to migrate from the environment to organisms. Fish are exposed to both microplastics and heavy metals. In this paper, the toxic effects of heavy metal adsorption by microplastics on fish are reviewed, and the focus is on the toxic effects at the individual (survival, feeding activity and swimming, energy reserves and respiration, intestinal microorganisms, development and growth, and reproduction), cellular (cytotoxicity, oxidative damage, inflammatory response, neurotoxicity, and metabolism) and molecular (gene expression) levels. This facilitates an assessment of the pollutants’ impact on ecotoxicity and contributes to the regulation of these pollutants in the environment.
A Higher Dose of Staphylococcus aureus Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells
Authors: Yuan Jin , Xu Xiaoqian , Wang Zhongliang , Tong Ping , Meng Xuanyi , Wu Yong , Li Xin , Gao Jinyan , Chen Hongbing
Published: May 2023

Exposure to Staphylococcus aureus enterotoxin B (SEB) is one of the causes of food poisoning and is associated with several immune diseases due to its superantigen capability. This study aimed to characterize the differentiations of naïve Th cells stimulated with different doses of SEB. The expression of T-bet, GATA-3, and Foxp3 or secretion of IFN-γ, IL-4, IL-5, IL-13, and IL-10 were evaluated in wild-type (WT) or DO11.10 CD4 T cells co-cultured with bone marrow dendritic cells (BMDCs). We found that the balance of Th1/Th2 could be dominated by the doses of SEB stimulation. A higher SEB dose could induce more Th1 and a lower Th2/Th1 ratio in Th cells co-cultured with BMDCs. This different tendency of Th cell differentiation induced by the SEB complements the existing knowledge about SEB acting as a superantigen to activate Th cells. Additionally, it is also helpful in managing the colonization of S. aureus and food contamination of SEB.
Malacological Survey and Spatial Distribution of Intermediate Host Snails in Schistosomiasis Endemic Districts of Rwanda
Authors: Kagabo Joseph , Kalinda Chester , Nshimiyimana Project , Mbonigaba Jean Bosco , Ruberanziza Eugene , Nyandwi Elias , Rujeni Nadine
Published: May 2023

Background: Schistosomiasis, due to S. mansoni, is prevalent in Rwanda. However, there is a paucity of information related to the abundance, species, distribution, and infectivity of Schistosoma intermediate host snails. Methods: Snails were collected from 71 sites, including lakeshores and wetlands. Snails obtained were morphologically identified, and cercariae were shed using standard procedures. Cercariae were molecularly characterized using PCR. GPS coordinates were used to generate geospatial maps of snail distribution that were overlaid with geospatial distribution of schistosomiasis among pre-school children in the same areas. Results: Overall, 3653 snails were morphologically classified as Bulinus spp. and 1449 as Biomphalaria spp. A total of 306 snails shed cercariae, 130 of which were confirmed as S. mansoni cercaria by PCR. There was no significant difference in the proportion of S. mansoni cercariae in wetlands compared to lakeshores. Conclusion: Rwandan water bodies harbor an important number of snails that shed S. mansoni cercariae. Furthermore, a strong spatial correlation was observed between the distribution of schistosomiasis in children and the spatial distribution of snail infectivity with S. mansoni. The presence of Bulinus spp. Suggests a potential risk of S. haematobium, although molecular analysis did not show any current transmission of this parasite.
Evaluation of an Innovative Point-of-Care Rapid Diagnostic Test for the Identification of Imported Malaria Parasites in China
Authors: Lin Kangming , Wang Shuqi , Sui Yuan , Zhang Tao , Luo Fei , Shi Feng , Qian Yingjun , Li Jun , Lu Shenning , Cotter Chris , Wang Duoquan , Li Shizhu
Published: May 2023

Background: China was certified malaria-free by the World Health Organization on 30 June 2021. However, due to imported malaria, maintaining a malaria-free status in China is an ongoing challenge. There are critical gaps in the detection of imported malaria through the currently available tools, especially for non-falciparum malaria. In the study, a novel point-of-care Rapid Diagnostic Test designed for the detection of imported malaria infections was evaluated in the field. Methods: Suspected imported malaria cases reported from Guangxi and Anhui Provinces of China during 2018–2019 were enrolled to evaluate the novel RDTs. Diagnostic performance of the novel RDTs was evaluated based on its sensitivity, specificity, positive and negative predictive values, and Cohen’s kappa coefficient, using polymerase chain reaction as the gold standard. The Additive and absolute Net Reclassification Index were calculated to compare the diagnostic performance between the novel RDTs and Wondfo RDTs (control group). Results: A total of 602 samples were tested using the novel RDTs. Compared to the results of PCR, the novel RDTs presented sensitivity, specificity, PPV, NPV, and diagnostic accuracy rates of 78.37%, 95.05%, 94.70%, 79.59%, and 86.21%, respectively. Among the positive samples, the novel RDTs found 87.01%, 71.31%, 81.82%, and 61.54% of P. falciparum, P. ovale, P. vivax, and P. malariae, respectively. The ability to detect non-falciparum malaria did not differ significantly between the novel and Wondfo RDTs (control group). However, Wondfo RDTs can detect more P. falciparum cases than the novel RDTs (96.10% vs. 87.01%, p < 0.001). After the introduction of the novel RDTs, the value of the additive and absolute Net Reclassification Index is 1.83% and 1.33%, respectively. Conclusions: The novel RDTs demonstrated the ability to distinguish P. ovale and P. malariae from P. vivax which may help to improve the malaria post-elimination surveillance tools in China.
Seroprevalence of Epizootic Hemorrhagic Disease Virus in Guangdong Cattle Farms during 2013–2017, China
Authors: Lv Min-Na , Zhu Jian-Bo , Liao Shen-Quan , Yang Zhen-Xing , Lin Xu-Hui , Qi Nan-Shan , Chen Qin-Ling , Wu Cai-Yan , Li Juan , Cai Hai-Ming , Zhang Jian-Fei , Hu Jun-Jing , Xiao Wen-Wan , Zhang Xu , Sun Ming-Fei
Published: May 2023

Epizootic hemorrhagic disease (EHD) is an infectious viral disease caused by epizootic hemorrhagic disease virus (EHDV) and EHDV frequently circulates in wild and domestic ruminants. Sporadic outbreaks of EHD have caused thousands of deaths and stillbirths on cattle farms. However, not much is known about the circulating status of EHDV in Guangdong, southern China. To estimate the seroprevalence of EHDV in Guangdong province, 2886 cattle serum samples were collected from 2013 to 2017 and tested for antibodies against EHDV using a competitive ELISA. The overall seroprevalence of EHDV reached 57.87% and was highest in autumn (75.34%). A subset of positive samples were serotyped by a serum neutralization test, showing that EHDV serotypes 1 and 5–8 were circulating in Guangdong. In addition, EHDV prevalence always peaked in autumn, while eastern Guangdong had the highest EHDV seropositivity over the five-year period, displaying apparent temporal–spatial distribution of EHDV prevalence. A binary logistic model analysis indicated a significant association between cattle with BTV infections and seroprevalence of EHDV (OR = 1.70, p < 0.001). The co-infection of different serotypes of EHDV and BTV raises a high risk of potential genomic reassortment and is likely to pose a significant threat to cattle, thus urging more surveillance to monitor their circulating dynamics in China.
Characterization of Human Papilloma Virus in Prostate Cancer Patients Undergoing Radical Prostatectomy—A Prospective Study of 140 Patients
Authors: Nellessen Tobias , Ebner Benedikt , Pyrgidis Nikolaos , Ledderose Stephan , Kretschmer Alexander , Marcon Julian , Teupser Daniel , Mayr Doris , Faihs Valentina , Stief Christian G. , French Lars E. , Herlemann Annika , Reinholz Markus
Published: May 2023

Introduction: The association between human papilloma virus (HPV) and the pathogenesis of prostate cancer (PCa) is still controversial. Existing studies often lack information about clinical risk factors, are limited by their retrospective design or only use a single detection method for HPV. Material and Methods: A total of 140 patients undergoing radical prostatectomy (RP) for PCa at the Department of Urology, Ludwig Maximilian University of Munich, Germany, were prospectively enrolled. Knowledge of HPV and sociodemographic parameters were assessed with questionnaires. The following methods were used for HPV detection: RP specimens were tested for HPV DNA by PCR. If HPV DNA was detected, an LCD-Array hybridization technique was used for HPV subtyping, and immunohistochemical staining for p16 was performed as a surrogate marker for HPV infection. Serological titers of HPV-16 L1 antibodies were measured using an HPV-16-specific immunoassay. Results: HPV DNA was detected in 9.3% (13/140) of RP specimens, with HPV-16 being the most predominantly detected subtype (5/13 = 39%). HPV-16 L1 antibody levels were below the limit of detection in 98% of patients (137/140). We found no significant difference between HPV PCR-positive (HPV+) and -negative (HPV-) patients in terms of HPV-16 antibody levels, history of HPV-associated diseases, level of education or marital status. Seventy-five percent of all PCa patients had never heard of HPV before. An acinar adenocarcinoma of the prostate was the most frequently detected histologic type in both HPV+ (100%) and HPV− (98%) patients (p = 0.86). HPV+ patients had fewer positive biopsy cores (3.5 vs. 5.8; p = 0.01) and a lower maximal tumor infiltration rate per core (37% vs. 57%; p = 0.03) compared to HPV- patients. However, when analyzing the whole prostate and the lymph nodes after RP, there were no significant differences in TNM stage, Gleason score or tumor volume between both groups. In a subgroup analysis of all high-risk HPV patients (n = 6), we found no significant differences in sociodemographic, clinical or histopathological parameters compared to HPV- or low-risk HPV+ patients. Conclusion: In our prospective study, we were not able to prove a clinically significant impact of HPV status on tumor characteristics in RP specimens. Most men with PCa had never heard of HPV, despite its proven causal association with other tumor entities.
Safety and Protective Effects of Influenza Vaccination in Pregnant Women on Pregnancy and Birth Outcomes in Pune, India: A Cross-Sectional Study
Authors: Shaikh Hanif , Koli Pranesha , Undale Vaishali , Pardeshi Anil , Asalkar Mahesh , Sahastrabuddhe Sushant , Kawade Anand , Upasani Chandrashekhar
Published: May 2023

Background: Maternal influenza vaccination provides effective protection against influenza infections in pregnant women and their newborns. In India, the influenza vaccine has not yet been offered through immunization programs, owing to the lack of sufficient safety data for pregnant Indian women. Methods: This cross-sectional observational study enrolled 558 women admitted to the obstetrics ward of a civic hospital in Pune. Study-related information was obtained from the participants through hospital records and interviews using structured questionnaires. Univariate and multivariable analysis was used, and the chi-square test with adjusted odds ratio was estimated to account for vaccine exposure and the temporal nature of each outcome, respectively. Results: Women not vaccinated against influenza during pregnancy had a higher risk of delivering very LBW infants, and possible protective effects were suggested (AOR 2.29, 95% CI 1.03 to 5.58, p = 0.03). No association was observed between maternal influenza vaccination for Caesarean section (LSCS) (AOR 0.97, 95% CI, 0.78, 1.85), stillbirth (AOR 1.8, 95% CI 0.18, 24.64) and NICU admission (AOR, 0.87, 0.29 to 2.85), and congenital anomaly (AOR, 0.81, 0.10 to 3.87). Interpretation: These results show that the influenza vaccine administered during pregnancy is safe and might lower the risk of negative birth outcomes.
Benzimidazole Resistance in Cattle: The First Report of the Presence of F200Y Mutation in Cooperia in Ecuador
Authors: Vinueza Pamela , Calispa Marlon , Condolo Luis , Toalombo Paula , Geldhof Peter
Published: May 2023

Anthelmintic resistance among GINs in cattle is a worldwide issue. Identifying the early signs of anthelmintic resistance (AR) is necessary to sustainably manage bovine parasitic infections. This study aimed to evaluate the resistance status of bovine parasitic nematodes against FBZ on a farm with a known history of broad-spectrum anthelmintic usage in Ecuador. FBZ efficacy was analyzed using a fecal egg count reduction test (FECR test) and β-tubulin 1 mutation identification in Cooperia spp., the dominant nematode parasite identified before and after treatment. According to the FECR test, the nematode population was susceptible to FBZ. After amplifying and cloning the β-tubulin 1 of Cooperia spp., an F200Y mutation was found in 43% of the pooled larva coproculture after treatment. This study reports, for the first time, the presence of F200Y resistance-conferring mutation in Cooperia spp. in Ecuador. Although the nematode population was phenotypically susceptible to FBZ, the presence of F200Y suggests the existence of resistance in the early stages. Our findings highlight the need to implement alternative control strategies for parasitic infections besides broad-spectrum anthelmintics.
Assessing the Welfare of Technicians during Transits to Offshore Wind Farms
Authors: Uzuegbunam Tobenna D. , Forster Rodney , Williams Terry
Published: May 2023

Available decision-support tools rarely account for the welfare of technicians in maintenance scheduling for offshore wind farms. This creates uncertainties, especially since current operational limits might make a wind farm accessible but the vibrations from transits might be unacceptable to technicians. We explore technician exposure to vibration in transit based on the levels of discomfort and the likelihood of seasickness occurring on crew transfer vessels (CTVs). Vessel motion monitoring systems deployed on CTVs operating in the North Sea and sea-state data are used in a machine learning (ML) process to model the welfare of technicians based on operational limits applied to modelled proxy variables including composite weighted RMS acceleration (aWRMS) and motion sickness incidence (MSI). The model results revealed poor to moderate performance in predicting the proxies based on selected model evaluation criteria, raising the possibility of more data and relevant variables being needed to improve model performance. Therefore, this research presents a framework for an ML approach towards accounting for the wellbeing of technicians in sailing decisions once the highlighted limitations can be addressed.
Prediction of Future Urban Rainfall and Waterlogging Scenarios Based on CMIP6: A Case Study of Beijing Urban Area
Authors: Wang Yiwen , Zhang Zhiming , Zhao Zhiyong , Sagris Thomas , Wang Yang
Published: May 2023

Extreme weather events will become more frequent and severe as a result of climate change, necessitating an immediate need for cities to adapt to future climate change. Therefore, the prediction of future precipitation and waterlogging is of utmost importance. Using Beijing as an example, the simulation capability of different models was evaluated, and the optimal model for the study area was screened using Taylor diagrams and interannual variability scores, along with actual monthly precipitation data from Chinese weather stations from 1994 to 2014 and historical monthly precipitation data from 10 coupled models from Coupled Model Intercomparison Project Phase 6 (CMIP6). The SWMM model was then used to simulate future rainfall and waterlogging scenarios for the study area using precipitation forecast data for 2020–2050 from the best model to investigate the impact of climate change on future rainfall and waterlogging in urban areas. CMIP6 brings together the most recent simulation data from major climate models on a global scale, providing a broader and more diverse range of model results and thereby making future predictions more accurate and dependable, and its findings provide a theoretical foundation for the emergency management of and scientific responses to urban flooding events. The following major conclusions were reached: 1. The best-performing models are EC-Earth3, GFDL-ESM4, and MPI- ESM1-2-HR. EC-Earth3 is a modular Earth system model developed collaboratively by a European consortium. MPI-ESM1-2 is a climate precipitation prediction model developed in Germany and promoted for global application, whereas the GFDL-ESM4 model was developed in the United States and is currently employed for global climate precipitation simulations. 2. Under future climate circumstances, the total annual precipitation in the example region simulated by all three models increases by a maximum of 40%. 3. Under future climatic conditions, urban surface runoff and nodal overflow in the study area will be more significant. The node overflow will become more severe with the increase in climate scenario oppression, and the potential overflow nodes will account for 1.5%, 2.7%, and 2.9% of the total number of nodes under the SSP1–2.6, SSP2–4.5, and SSP5–8.5 scenarios, respectively. 4. In the future, the effectiveness of stormwater drainage systems may diminish. To increase climate change resilience, the impacts of climate change should be considered when planning the scope of stormwater optimization and the integrated improvement of gray–green–blue facilities.
Waterway Channel Stability and Management Measures of Chenglingji—Wuhan Reaches in the Middle Section of the Yangtze River
Authors: Zhang Xiabo , Yang Yunping , Li Ming , Zhang Mingjin , Wang Jianjun , Xin Weiyan
Published: May 2023

In China’s Yangtze River Basin, systematic waterway improvement and dredging maintenance have increased the waterway water depth compared with that before the implementation of the Three Gorges Project. Although the water depth of the middle section increased from 2.9 m in 2002 to 4.2 m in 2021, it remains less than 6.0 m in the lower section and 4.5 m in the Three Gorges Reservoir area. This study explores the Chenglingji—Wuhan reaches in the middle section of the Yangtze River, using hydrological data from 1954 to 2021 and topographic data from 2002 to 2021 to analyze river channel scouring or deposition characteristics, verify the waterway scale with a multi-scale width of 4.5 m water depth, and propose waterway management countermeasures. After the implementation of the Three Gorges Project, the Chenglingji—Wuhan reaches were scouring using a low-flow channel (94.95%), thereby facilitating waterway depth improvement. A serious obstruction area was located in the branching channel, and an unstable relationship between the boundary of the continental bank and the branching channel was found to be the main factor hindering navigation, with a water depth below 4.5 m. The Chenglingji—Wuhan reaches waterway water depth has been raised from 2.9 m in 2003 to 4.2 m; it can be raised to 4.5 m through waterway scale improvement. This study explains the navigation obstruction characteristics of alluvial waterways, which has important reference value for waterway scale improvement and planning, and the efficient utilization of deep-water resources.
Settlement Behavior of Composite Foundation with Deep Mixed Piles Supporting Highway Subgrades in Water-Rich Flood Plains
Authors: Liu Shuang , Guo Panpan , Li Xian , Wang Kai , Tang Rui , Wang Yixian
Published: May 2023

The settlement behavior of composite foundations plays an important role in the serviceability and stability of the subgrade or other infrastructures supporting the foundation. However, in water-rich flood plains, due to the complexity of the soft soil properties, the settlement behavior has not been well understood. The objective of this study is to investigate the effects of various key factors on the settlement behavior of composite foundations with deep mixed piles supporting highway subgrade in water-rich flood plains. The investigated subgrade is in operation, and the vehicle load is taken into account. The G347AH Project is considered in this study. Several typical models for predicting composite foundation settlements are discussed. By performing three-dimensional finite difference analysis, a comparison is made between the settlement behavior of the natural foundation and the composite foundation with deep mixed piles. Based on the single factor sensitivity analysis and the multi-factor orthogonal experimental design, the effects of pile length, pile diameter, pile spacing, pile elasticity modulus, cushion elasticity modulus, and cushion thickness on the composite foundation settlement are captured. It is found that among these factors, the degree of influence of pile length is superior. The composite foundation settlements predicted by the models agree well with the field-monitoring data, with the error being about 8.42% and 6.38%, respectively, at two monitoring sections. The research conducted in this paper can effectively reduce the probability of various settlement-related disasters occurring on highway subgrades in water-rich flood plains. Moreover, the research has important theoretical guidance for design optimization in terms of settlement control of highway subgrades in soft soil areas.