bluuebunny/crossref_metadata_2025 huggingface dataset:
Magnesium Alloy Welding Wire, 4.2Zn - 1.2 Rare Earths - 0.7Zr (ZE41A)
Authors:   AMS D Nonferrous Alloys Committee
Published: April 2024

This specification covers a magnesium alloy in the form of welding wire (see 8.5).
Steel, Corrosion-Resistant, Sheet and Strip 18Cr - 8Ni (301) Cold Rolled, 125 ksi (862 MPa) Tensile Strength
Authors:   AMS F Corrosion and Heat Resistant Alloys Committee
Published: April 2024

This specification covers a corrosion-resistant steel in the form of sheet and strip 0.005 inch (0.13 mm) and over in nominal thickness.
AKHLAK ATAU ETIKA GURU MENURUT KH AHMAD DAHLAN DAN KH HASYIM ASY’ARI
Authors: Moh. Khakim  , Muhammad Devy Habibi
Published: April 2024

This research is based on the author's concern regarding the recent decline in teacher morals/ethics. Judging from the large amount of coverage regarding the behavior of individual teachers, such as cases of sexual abuse against several students. The aim of this research is to obtain further information regarding the views of K.H. Ahmad Dahlan and K.H. Hasyim Asy'ari regarding the morals and ethics of an educator. The type of research or model used by the author is a type or form of qualitative research, which takes the form of library research, which is carried out by evaluating several related data, either from primary sources (Primary Sources) or secondary sources (Secondary). The findings from the research show that there are fewer differences and more similarities between the views of K.H. Ahmad Dahlan and K.H. Hasyim Asy'ari regarding the ethics of an educator in the context of Islamic Religious Education (PAI). Meanwhile, the apparent dissimilarity between the two of them regarding teacher ethics lies in Kiai Ahmad Dahlan's perspective on the relationship between teachers and students. K.H. Ahmad Dahlan emphasized the importance of educators being open, with the belief that the teaching and learning process can occur in various places and at any time. Not a few of his students became friends in their struggle, highlighting the importance of openness and a close relationship between a teacher and his students. Kiai Hasyim Asy'ari, on the other hand, shows caution, a teacher must maintain his authority. With the existing differences, the author can conclude that if the elements emphasized by Kiai Ahmad Dahlan al-Haj and Kiai Hasyim Asy'ari al-Haj are combined, a teacher's morals or ethics will be formed that are very positive and perfect each other.
Diffusion-weighted MR Imaging in Intracranial Infections
Authors: Lim C C T , Lee W , Chng S M , Sitoh Y Y , Hui F
Published: April 2024

Introduction: Diffusion-weighted magnetic resonance (MR) imaging (DWMRI) is valuable in the assessment of acute cerebral infarction and may be useful for other diseases of the central nervous system (CNS). In this study, we present the DWMRI appearance of intracranial infection.

Materials and Methods: Thirty patients with clinical diagnosis of CNS infection were reviewed. All patients underwent conventional contrast-enhanced MR examination and DWMRI using single-shot echo-planar imaging at b = 1000 s/mm2.

Results: Cerebral abscess, tuberculoma, subdural empyema and epidural abscess were hyperintense on DWMRI. Neurocysticercosis showed hypointense lesions on DWMRI. Four of 5 patients with encephalitis showed DWMRI hyperintensity; the appearance of toxoplasmosis lesions was variable. Patients suffering from meningitis without parenchymal involvement did not exhibit any abnormality of diffusion. One patient with tuberculous meningitis developed abnormality on DWMRI from acute cerebral infarction.

Conclusion: DWMRI increased lesion conspicuity and may be useful in assessment of cerebral infection. There were striking differences in the DWMRI appearances caused by different organisms and diseases.
Brachiocephalic-Superior Vena Cava Metallic Stenting in Malignant Superior Vena Cava Obstruction
Authors: Lau K Y , Tan L T H , Wong W W C , Lee A S L
Published: April 2024

Introduction: We studied the effectiveness of unilateral brachiocephalic (BC)-superior vena cava (SVC) metallic stent therapy in malignant SVC obstruction.

Materials and Methods: From November 1998 to February 2002, SVC stenting was performed in 11 patients with symptomatic malignant SVC obstruction. There were 10 males and 1 female, with a mean age of 64.2 years (range, 37 to 78 years). The computed tomography (CT) scan and superior vena cavogram findings of all patients showed malignant SVC obstruction. Both internal jugular veins were patent in all patients by ultrasound. SVC stenting was performed with Wallstent (Boston Scientific, Minneapolis, MN, USA) in 10 patients and Memotherm stent (Bard angiomed, Wachhausstraße, Germany) in 1 patient. Pressure gradient, duration of the procedure, peri-procedural morbidity and mortality and the general well-being of the patients were reviewed.

Results: SVC stenting was performed at a mean duration of 9.6 days (range, 3 to 30 days) after presentation. All were technically successful with 10 across the right BC-SVC and 1 across the left BC-SVC. There was no peri-procedural morbidity or mortality. The entire procedure was completed at a mean duration of 115 minutes (range, 75 to 225 minutes) with good angiographic and pressure results. Immediate symptomatic relief of SVC syndrome was achieved in 10 patients who had received prompt work-up and stenting 3 to 18 days after presentation. The remaining patient, who received work-up and stenting 30 days after presentation, remained dyspnoeic and died of pneumonia 7 days after the procedure.

Conclusion: Unilateral BC-SVC metallic stenting is an effective measure in malignant SVC obstruction. Prompt pre-stenting work-up and stenting are recommended to achieve a longer symptomatic relief period.
Imaging of Congenital Middle Ear Deafness
Authors: Tan T Y , Goh J P N
Published: April 2024

Introduction: Conductive hearing loss, in the presence of a normal external ear, is usually due to an interference with the normal transmission of sound from the tympanic membrane across the ossicular chain to the oval window. If conductive hearing loss occurs in a young child, congenital middle ear pathology is the most likely cause.

Materials and Methods: High resolution computed tomography of the middle ear is the diagnostic modality of choice. Details of the imaging technique are outlined in this article. Eight cases of congenital middle ear deafness imaged in the radiological departments of Changi General Hospital and Tan Tock Seng Hospital in Singapore are illustrated.

Results: Congenital middle ear deafness may be classified into ossicular chain abnormalities, congenital ossicular fixation, congenital oval window atresia and congenital round window atresia. The imaging features for each category are described.

Conclusion: With proper imaging technique and a systemic analysis of the images, the abnormalities that result in congenital middle ear deafness can usually be demonstrated on most occasions.
Imaging-guided Bone Biopsy
Authors: Peh W C G
Published: April 2024

Imaging-guided percutaneous bone biopsy can be rapidly performed under local anaesthesia with little patient discomfort. It has a useful role in the diagnosis and management of patients with bone lesions. The indications, contraindications, general principles, technique and possible complications of bone biopsy, performed using computed tomography guidance, are highlighted in this update.
The Effectiveness of Project-Based Learning Model Assisted By Design Thinking on Experimenting Skills in Grade IV Science and Technology Learning in Dagangan Sub-District
Authors:   Universitas Sebelas Maret, Surakarta, Indonesia, Puspitasari Septa Dwi , Daryanto Joko ,   Universitas Sebelas Maret, Surakarta, Indonesia, Widianto Idam Ragil ,   Universitas Sebelas Maret, Surakarta, Indonesia
Published: April 2024

The purpose of this study was to determine the effectiveness of project-based learning model on experimental skills. The type of research is quantitative. The population was grade VI elementary schools in Dagangan sub-district, Madiun district. The sampling technique used was random sampling. The research sample was SD Negeri Sewulan 02 and SD Negeri Dagangan 02, each with 20 students. The source of data is IPAS learning with material changes in form. Data collection through tests and observations. Data analysis using Paired t-tests and N-gain test for effectiveness test. The results showed that the Paired t-test test for the post-test results of the experimental group obtained data that was significant (2-tailed) less than 0.05 (Sig < 0.05) so it could be interpreted that there was a difference; N-gain effectiveness test = 70.70% with very high criteria; and 83.44% participant activeness with high criteria. In conclusion, the project-based learning model assisted by design thinking is effective in improving students' ability to experiment.
The Effect of Swimming Pool Water Quality on Health Complaints of Child Athletes Using the Swimming Pool (FIKK UNY)
Authors:   Department Primary School Physical Education, Postgraduate Program, Yogyakarta State University, Yogyakarta 55281 Indonesia, Munajad Sigit Kustriyono
Published: April 2024

The study aims to determine the effect of swimming pool water quality on the health complaints of children and athletes using the FIKK UNY swimming pool. The research method used was descriptive correlational research. Primary data collection techniques include observation, questionnaires, and interviews, as well as secondary data obtained from books, journals, literature, documentation, and theses related to this research. This research was conducted at the FIKK UNY swimming pool with a population of all children's swimming athletes who use the FIKK UNY swimming pool, as many as 75 children. The sample was determined by random sampling, which amounted to 50 children who were given a questionnaire several times in January 2024. The data analysis techniques used in this research are descriptive analysis and inferential analysis using the SPSS version 26.0 computer program. The results showed that: 1) The description of the water quality of the FIKK UNY swimming pool is in the high value category (meeting health requirements) (64%); 2) The description of user health complaints at the FIKK UNY swimming pool is in the high value category (no health complaints) (56%); 3) Swimming pool water quality has a positive and significant influence on health complaints of child athletes using the FIKK UNY swimming pool (significance value α = 0.00 0.05). Based on the results of the study, the authors suggest to swimming pool managers that they pay attention to the quality of their swimming pool water so that it meets the requirements of PermenKES RI Number 32 of 2017 concerning swimming pool water management, which includes physical, chemical, and microbiological parameters. Parties related to swimming pools are expected to provide counseling on the importance of swimming pool water quality for child athletes in particular and all pool users in general.
Family Support in Premarital Screening: Efforts to Prevent Thalassemia
Authors:   University of Muhammadiyah Purwokerto, Jl.Lt. Gen. Soepardjo Roestam Km 7 PO. Box 229 Purwokerto 53181, Susilo Rakhmat , Rosyani Muliyah ,   University of Muhammadiyah Purwokerto, Jl.Lt. Gen. Soepardjo Roestam Km 7 PO. Box 229 Purwokerto 53181
Published: April 2024

Thalassemia is an inherited disorder syndrome and is included in the hemoglobinopathy group, which is a disorder caused by impaired hemoglobin csynthesis due to mutations in or near globin genes. Thalassemia disease has no cure, so early prevention is more important than treatment. The World Health Organization recommends two ways of prevention, namely pregnancy screening and population screening to look for carriers of thalassemia traits. This study aims to determine the relationship between family support and premarital screening decision-making in thalassemia adolescents at Banyumas Regional General Hospital. The method used is quantitative descriptive. This study is a correlation study with a cross-sectional design. The sample in this study was thalassemia adolescents with an age range of 12 to 21 years in the thalassemia room of Banyumas Regional General Hospital as many as 75 people. This study used a sampling technique, namely purposive sampling. The research instrument used family support questionnaires and decision-making. The data were analyzed using the Chi-Square test. Univariate test results found that most respondents had high family support as many as 52 people (69.3%), and most respondents decided to conduct premarital screening as many as 54 people (72.0%). The results of the bivariate test obtained a relationship between family support and premarital screening decision-making in thalassemia adolescents in the thalassemia room of Banyumas Regional General Hospital (p-value 0.047). Family support can also be an influential factor in determining an individual's beliefs and decisions. The higher the family support, the more supportive the thalassemia adolescent to make premarital screening decisions.
Industry Type, Profitability and Convergence of IFRS to Audit Fees
Authors:   Palembang Muhammadiyah University & South Sumatra, Indonesia, Ningsih Nurul Hutami
Published: April 2024

This research aims to determine the relationship between industry type, profitability, and IFRS convergence with audit fees. This research is associative research that connects each research variable using data taken directly online at the Indonesian Stock Exchange. This research collects data from the annual reports of basic industrial and chemical manufacturing companies listed on the Indonesian Stock Exchange for 2020-2022, with purposive sampling being the technique used in sampling. A total of 27 companies were respondents with an observation period of 3 years. Quantitative methods were used to analyze this research by processing data using the Statistical Program for Special Science (SPSS). The research results show that industry type has a relationship with audit fees, while profitability has no relationship with audit fees, and the same as industry type, IFRS convergence has a relationship with audit fees.
Radiation and Radiation Protection Awareness among Medical Imaging Program Students
Authors:   Çanakkale Onsekiz Mart University, Health Service Vocational College, Çanakkale-Turkey, Nişancı Bengüsu Nur , Çakına Suat ,   Çanakkale Onsekiz Mart University, Health Service Vocational College, Çanakkale-Turkey
Published: April 2024

With the technological developments in the field of health, the use of radiation in medicine is increasing day by day. The radiation awareness of healthcare personnel working in radiation is also very important in terms of both their own protection and the protection of patients from radiation. The aim of this study is to reveal the level of knowledge about radiation and radiation protection of students from Çanakkale Onsekiz Mart University Vocational School of Health Services, which provides Medical Imaging and Radiology education in Çanakkale province, who are doing practice/internship/skill training in diagnostic radiology units of hospitals and whether this awareness differs according to various individual and demographic characteristics. For this purpose, a questionnaire including both demographic characteristics and the scale was applied to 189 university students to obtain the data set. For the statement "I have knowledge about X-rays", 3.2% of the 1st grade students strongly disagreed, 8.4% were undecided, 69.5% agreed, 4.2% disagreed and 14.7% strongly agreed, while 1.1% of the 2nd grade students strongly disagreed, 2.1% were undecided, 75.5% agreed and 20.1% strongly agreed (p=0.04). In general, no difference was found between the 1st and 2nd grades when the level of knowledge about radiation and radiation protection was evaluated. In order to reinforce the topics related to radiation, it would be useful to repeat the topics frequently in the courses and to prepare current presentations by experts in the field and to present them as seminars within the scope of in-service training for both students and Radiology Technicians professionally.
Deconstructing Intellectual Property Rights in Fanfiction: A Case Study on Copyright Protection and Moral Rights
Authors:   Faculty of Law, Universitas Diponegoro, Jl. dr. Antonius Suroyo, Tembalang, Semarang, Indonesia, Anggayasti Umaira Hayuning , Amalia Ardina Nur ,   Faculty of Law, Universitas Diponegoro, Jl. dr. Antonius Suroyo, Tembalang, Semarang, Indonesia
Published: April 2024

The protection of intellectual property rights serves to safeguard the interests of creators by granting them exclusive ownership rights over their creative works. Copyright includes both ethical rights and financial rights. Fanfiction is safeguarded by copyright, which is a form of intellectual property rights. This article presents a case study examining the role of Intellectual Property Rights and Moral Rights in the context of Fanfiction with Normative Legal Research. The fair use doctrine, as implicitly articulated in Article 44, paragraph (1) of the IPR Act of Indonesia and comparation with another regulation, is encompassed within this category. Furthermore, the considerable similarity test is utilized to assess the degree to which similarities and actuality exist in the work. The pattern test entails the analysis of the narrative structure and overall depiction. Finally, the feel and total idea test is employed to assess the essence and attributes of the writing, as well as the implementation of parallels in narrative themes. The establishment of legislation concerning Fanfiction is of utmost importance in order to delineate distinct boundaries between creative pursuits and legal violations. Ensuring the protection of novelists and amateur writers who have a profound emotional attachment to the narratives they have encountered is of utmost importance, as it cultivates their propensity to generate alternative stories.
Meckel's Diverticulum: A Literature Review of Basic Concepts, Diagnosis and Treatment Options
Authors:   Surgical Resident. Clínica Hospital Mérida, ISSSTE. Facultad de Medicina de la Universidad Autónoma de Yucatán., Echeverría Alexis Emir Noguera , Guerrero María Fernanda Ibarra ,   Pediatrics Resident. Clínica Hospital Mérida, ISSSTE. Facultad de Medicina de la Universidad Autónoma de Yucatán., Morales Mauricio Gerardo Martínez ,   Surgical Resident. Hospital General de México “Dr. Eduardo Liceaga”, Secretaría de Salúd. Universidad Autónoma de México., Villaseñor Enzo Alejandro Herrera ,   Social Service MD Intern. Universidad Anáhuac Mayab., Loeza Duran Carlos Aaron ,   Social Service MD Intern. Universidad Anáhuac Mayab., Ruz Alcocer Alison Mariel ,   Social Service MD Intern. Universidad Anáhuac Mayab., Triay Novelo Felipe de Jesús ,   Social Service MD Intern. Universidad Marista., Auguste Guiscenthia Rose Tharlene ,   Social Service MD Intern. Universidad Marista., Arcos García Ariadna del Jesús ,   Medical Intern. Universidad Anáhuac Cancún., Domínguez Andrea Polett Quiroz ,   Medical Intern. Universidad Anáhuac Cancún., Ortega Alix Fernanda Castellanos ,   Medical Intern. Universidad Anáhuac Cancún., Reyes Minerva Jiménez ,   Medical Intern. Universidad Anáhuac Mayab., Forfori Palomo Mathilda Giorgia ,   Medical Student. Universidad Anáhuac Cancún., Guerrero Carlos Enrique Luna ,   General Surgeon. Universidad Autónoma de Sinaloa., López Rico Luis Armando ,   General Surgeon. Universidad de Guadalajara., Glaxiola Jackeline García ,   Social Service MD Intern. Universidad de Guadalajara.
Published: April 2024

Meckel's diverticulum (MD) is a common congenital anomaly of the gastrointestinal tract, characterized by an outpouching in the terminal ileum. It can be symptomatic in various ways, most commonly causing ulcers and gastrointestinal bleeding. Complications such as bleeding, perforation, diverticulitis, or intestinal obstruction may develop in approximately 4% of patients. Diagnosis can be challenging, but a CT scan is often the tool of choice, particularly for identifying complications. Surgical procedures like laparoscopy or laparotomy provide a more accurate diagnosis. Treatment typically involves surgical removal of the diverticulum, with laparoscopy being a safe and effective method. Risk factors for acute complications in adults include age under 50, male sex, MD length over 2 centimeters, and intradiverticular tissue abnormalities.
Optimization of Emergency Epidemic Prevention Material Reserve and Supply System of Shanxi Province in China: Based on Anylogic Simulation
Authors:   Shanxi Agricultural University, Taiyuan, China, 030031, Tianrui Zhang , Yuanyuan Guo ,   Shanxi Agricultural University, Taiyuan, China, 030031, Tianle Gao ,   Shanxi Agricultural University, Taiyuan, China, 030031, Jinyu Zhang ,   Shanxi Agricultural University, Taiyuan, China, 030031, Shu Li ,   Shanxi Agricultural University, Taiyuan, China, 030031, Xinghua Wang ,   Shanxi Agricultural University, Taiyuan, China, 030031
Published: April 2024

Due to the randomness and uncertainty of epidemic occurrence, there are insufficient emergency supplies and low efficiency of transportation equipment in Shanxi Province. In order to meet the needs of materials in Shanxi Province, it is urgently necessary to establish a reserve and supply system with perfect facilities and equipment. According to the geographical location of 11 prefecture-level cities in Shanxi Province and the actual situation of transportation equipment, this paper simulates the location of warehouse construction in each city. Through simulation modeling, the emergency epidemic prevention materials reserve and supply system of prefecture-level cities in Shanxi Province was simulated under the epidemic situation. The research idea of "simulation-analysis-optimization-summary" was defined, and the AnyLogic software was used to simulate and analyze the emergency epidemic prevention materials reserve and supply system of the whole Shanxi Province. Through the simulation of different scenarios, the optimization direction of transportation equipment is obtained. Based on the optimization effect of each plan of transportation equipment loading on the emergency epidemic prevention materials reserve and supply system in Shanxi Province, the best optimization plan was obtained. The results show that the efficiency of transportation equipment allocation is improved and the loading capacity of transportation equipment is reasonable and effective. After optimization, the order backlog of each prefecture-level city storage warehouse is reduced, and the order processing time is reduced. The optimization ideas proposed in this paper provide the optimization direction for the emergency epidemic prevention materials reserve and supply system in Shanxi Province, and also have certain guiding significance for how to deal with major public health emergencies.
Granuloma anular y diabetes mellitus, una asociación infrecuente en pediatría
Authors: Aráoz María Josefina , Stefano Paola Cecilia , Bocian Marcela , Centeno María del Valle , Cervini Andrea Bettina
Published: April 2024

El granuloma anular (GA) es una dermatosis granulomatosa y benigna, de etiología desconocida. En los niños las formas clínicas más frecuentes son la localizada, que se presenta como una placa eritematosa, anular, no escamosa; y la subcutánea, representada por un nódulo indoloro y firme, que compromete habitualmente los miembros inferiores. En los adultos, el GA se ha asociado a la diabetes mellitus, pero existen pocos casos descriptos sobre esta asociación en pediatría. Se presenta una paciente de 8 años de edad, previamente sana, con lesiones de granuloma anular, confirmada por histopatología y diagnóstico posterior de diabetes mellitus tipo 1.
Causas y presentación clínica de dermatomiositis inducida por drogas. Revisión sistemática
Authors: Minaudo Carla
Published: April 2024

Se realizó una búsqueda en Pubmed, y se analizaron y seleccionaron artículos con casos que cumplían con la escala de Naranjo para reacciones adversas a drogas. Se obtuvieron datos de 165 pacientes.

La dermatomiositis (DM) inducida por drogas se presenta con placas eritematosas foto distribuidas, eritema periorbitario, signo y pápulas de Gottron, similares a la DM idiopática.

En esta revisión la droga asociada más frecuente fue la hidroxiurea (30,3%), seguida de los inhibidores check-point (16,4%), las estatinas (13,3%), la penicilamina (6,1%) y los anti TNFα (6,1%).

Ochenta y cinco pacientes (51,6%) presentaron cáncer (leucemia mieloide crónica, melanoma, cáncer de mama y policitemia vera), mientras que otros 15 tuvieron antecedentes de enfermedades reumatológicas (artritis reumatoide, DM y psoriasis).

Hubo un promedio de 60 días desde el inicio del fármaco y la manifestación de la DM.

La biopsia de piel se efectuó en 58 pacientes (35,2%) y mostró cambios vacuolares de interfase y depósitos de mucina.

En cuanto a los autoanticuerpos, los más frecuentes fueron el FAN, el anti-TIF-1γ, y los menos frecuentes el anti-jo-1, anti-Mi-2, anti-Ro y otros autoanticuerpos.

Setenta y dos pacientes (43,6%) presentaron debilidad muscular. La electromiografía y la resonancia magnética mostraron miopatía en más del 80% de estos pacientes.

El compromiso pulmonar se investigó en pocos casos con solo 6 pacientes con TAC con patrón intersticial y un paciente con pruebas funcionales alteradas. Los autores destacan la menor afectación respiratoria con respecto al 42% al 53% reportado para la DM idiopática.

Por último, los autores mencionan como otras drogas desencadenantes a los bifosfonatos y los AINE, y destacan la importancia de tener un bajo umbral de sospecha de DM inducida por drogas en pacientes que reciben cualquiera de las medicaciones mencionadas y presentan lesiones en zonas fotoexpuestas y/o debilidad muscular.
Eficacia de espironolactona comparada con doxiciclina en acné moderado en mujeres adultas: resultados del estudio FASCE
Authors: Minaudo Carla
Published: April 2024

El acné de la mujer adulta se caracteriza por la influencia hormonal con rebrotes premenstruales en el 60% de las pacientes y por la resistencia bacteriana del Cutibacterium acnes debido a tratamientos previos con antibióticos. Esto último limita la respuesta a las ciclinas usualmente usadas en acné. La espironolactona inhibe a la 5-alfa reductasa en las glándulas sebáceas y también la producción de LH a nivel hipofisario. Además, tiene una efectividad conocida en este tipo de acné, aunque hasta el momento su uso es por fuera del prospecto y faltan estudios de eficacia y seguridad comparados con tratamientos antibióticos.

Esto motivó a los autores a realizar este ensayo multicéntrico, randomizado, doble ciego, prospectivo y paralelo para comparar la eficacia de la espironolactona versus la doxiciclina en el acné de la mujer adulta. Se lo denominó estudio FASCE.

Se incluyeron 133 pacientes. Se excluyeron aquellas con síndrome de ovario poliquístico. Las mujeres tratadas utilizaban métodos anticonceptivos, en su mayoría hormonales. Las ramas del estudio fueron: 1) doxiciclina 100 mg/día y peróxido de benzoilo por 3 meses seguido de 3 meses de placebo y peróxido de benzoilo; 2) espironolactona 150 mg /día y peróxido de benzoilo por 6 meses. El seguimiento total de las pacientes duró 12 meses.

Se realizaron evaluaciones a los 4 y a los 6 meses con los sistemas puntuación del Adult Female Acne Scoring Tool (AFAST) y el Acne Lesion Score Scale (ECLA) conteo de número de lesiones e índice de calidad de vida.

Analizando múltiples variables, la espironolactona mostró una respuesta superior de 1,37 a 2,87 veces con respecto a la doxiciclina a los 4 y 6 meses respectivamente. La espironolactona fue bien tolerada y la calidad de vida mejoró en las mujeres tratadas con este medicamento.

Sin embargo, los autores también observaron que la doxiciclina actuó con mayor rapidez, con mejoras dentro de los 2 meses; en cambio la espironolactona necesitó entre 2 y 4 meses.

Los efectos adversos prevalecieron en el grupo tratado con espironolactona, principalmente con irregularidades menstruales, aunque fueron leves y no requirieron suspender el tratamiento. No se presentaron casos de hiperkalemia secundaria a espironolactona.

Se concluye que aunque faltan más estudios que confirmen estos hallazgos, la espironolactona merece autorizarse como una alternativa eficaz y segura para el tratamiento del acné en la mujer adulta, siendo una alternativa a los antibióticos y potencialmente a la isotretinoina.
Side Collision Detection Model for Visually Impaired Using Monocular Object-Specific Distance Estimation and Multimodal Real-World Location Calculation
Authors: Song Wenqing , Sun Yumeng , Huang Qixuan , Cheok Junyang
Published: April 2024

Targeting the potential risk of side-vehicle collisions when the visually impaired crosses roads, this study proposed a side collision detection model, including monocular distance estimation, multimodal real-world location estimation, future location prediction and collision warning strategies tailored for visually impaired pedestrians. The proposed model employs YOLOv8 and DeepSort for vehicle detection and tracking, utilizing shallow neural networks for distance estimation based on image information and vehicle position data. Predicted vehicle distances are combined with magnetic field sensor and GPS data to compute and store real-world vehicle locations, and these location data will be used for linear regression to forecast future locations.  A warning strategy is then implemented to alert users. Experimental validation shows that the monocular distance estimation network has an Absolute Relative Error of 0.043 and an ALE (Average Localization Error) of 1.249m. In real-world location estimation, the view angle ALE is 0.019, and the location ALE is 1.778m. Regarding location prediction, the accuracy in distinguishing stationary and moving vehicles reaches 0.962, and the predicted curve, based on ground truth and predicted locations, exhibits good alignment. The proposed warning strategy, evaluated on Kitti Tracking Dataset and a self-created dataset, accurately detects the majority of potential collision risks.
 
Received: 17 November 2023 | Revised: 13 March 2024 | Accepted: 9 April 2024
 
Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
The data that support the findings of this study are openly available in "IEEE" at https://doi.org/10.1109/CVPR.2012.6248074.
 
Author Contribution Statement
Wenqing Song: Conceptualization, Methodology, Software, Data curation, Writing - original draft, Visualization, Supervision, Project administration. Yumeng Sun: Validation, Investigation, Writing - review & editing. Qixuan Huang: Methodology, Validation, Formal analysis, Resources, Writing - review & editing. Junyang Cheok: Validation, Investigation, Writing - review & editing.
Monte Carlo Simulation-Based Regression Tree Algorithm for Predicting Energy Consumption from Scarce Dataset
Authors: Darmanto Tony , Tjen Jimmy , Hoendarto Genrawan
Published: April 2024

Most data-driven techniques rely on the availability of data. Hence, when the data provided are not sufficient, the algorithm might not work as intended. Thus, it is important to be able to predict the dynamics of the data, even when the number of available data is low, or scarce. This study aimed to predict the power consumption of a building given a scarce dataset via a novel Monte Carlo simulation-based Regression Tree (MCRT) algorithm. The main idea is to train Monte Carlo simulation on each leaf generated by the regression tree algorithm. Thus, the prediction no longer depends on the average of the samples contained in the leaf, but now depends on the probability of the samples. The proposed algorithm was validated on 2 datasets obtained from Universitas Widya Dharma Pontianak (UWDP), Indonesia, and Trapeznikov Institute of Control Sciences (TICS), Russia. To show that the MCRT algorithm is better than the regression tree (RT) algorithm, a two-tail hypothesis was proposed. Based on the experiments which were run on Python software with 16 GB RAM, 7th Gen Core i7 machine on 50 datasets randomly generated from the UWDP electrical data, it can be concluded that the MCRT algorithm performs better than the previous RT algorithm used to model scarce datasets with P-value = 0.000319. Furthermore, the proposed algorithm improves the model predictive accuracy of the RT algorithm by up to 2%.
 
Received: 30 December 2023 | Revised: 21 March 2024 | Accepted: 8 April 2024
 
Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
The data that support the findings of this study are openly available in [Google Drive] at https://docs.google.com/spreadsheets/d/1o8sawOaOcX1kEm-dIdkcCUZhKoBduTAz/edit?usp=drive_link&ouid=115962907255429746256&rtpof=true&sd=true
 
Author Contribution Statement
Tony Darmanto: Conceptualization, Validation, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Visualization, Supervision, Project administration. Jimmy Tjen: Conceptualization, Methodology, Software, Formal analysis, Writing - original draft, Writing - review & editing, Visualization. Genrawan Hoendarto: Validation, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing.
The Potential of Purple Sweet Potato-based Food Bar as an Immunomodulator and Hepatoprotector Against Diethylnitrosamine-induced Mice
Authors: Widyaningsih Tri Dewanti , Sujuti Hidayat , Fibrianto Kiki , Honestin Trifena , Sigalingging Catherine Novita Sari
Published: April 2024

The food bar’s effect as an immunomodulator and hepatoprotector in vivo was tested on male BALB/c mice induced with diethylnitrosamine (DEN). The experimental animals were treated using the Post-test Control Group Design method. Six groups of 30 mice each made up the sample: The negative control group of healthy mice fed with a normal diet (P0); the group of healthy mice given the food bar (P1); the positive control group of mice induced with DEN and given a normal diet (P2); the group of mice induced with DEN and given a normal diet + food bar at 11,700 mg/kg (P3); the group of mice induced with DEN and given a normal diet + food bar at 23,400 mg/kg (P4); and the group of mice induced with DEN given the food bar (P5). The observations conducted included the spleen, which was used for the analysis of immunomodulators on T CD4+CD25+, CD4+, and CD8+ cells with cytokines TNF-α, IFN-Ɣ, and IL-10, blood serum for the analysis of SGPT and SGOT, and liver organ for the analysis of SOD, MDA, and histopathology. The results of the immunomodulator testing showed that the administration of the food bar (P5) significantly (p < 0.05) resulted in the highest percentage of CD4+ T cells at 2.93 % and CD8+ T cells at 5.30 %, a lower percentage of CD8+ T cells expressing proinflammatory cytokines (TNF-α at 0.27 % and IFN-γ at 0.29 %), a higher percentage of CD4+ T cells expressing CD25+, and CD25+ T cells expressing anti-inflammatory cytokines (IL-10) at 2.83 %. This group also exhibited the lowest levels of SGPT and SGOT, a higher percentage of SOD, and a lower percentage of MDA compared to other groups. The food bar, based on the mix of purple sweet potato, mung beans, moringa leaves, and strawberries, also reduced liver damage, as demonstrated through histopathological testing.
HIGHLIGHTS   

Food bar demonstrated effectiveness as an immunomodulator by increasing CD4+ and CD8+ T-cell populations, enhancing CD4+ T-cells expressing CD25+, elevating CD25+ expressing anti-inflammatory cytokine (IL-10), and reducing CD8+ T-cells suppressing the expression of proinflammatory cytokines (TNF-α and IFN-γ) in the spleens of DEN-induced mice
The provision of the food bar as the main diet resulted in reduced levels of SGPT, SGOT, and hepatic MDA in DEN-induced mice and increased SOD activity in mice induced with 50 mg/kg of DEN
Food bar based on purple sweet potato, green beans, moringa leaves, and strawberries was able to protect and reduce liver cell damage caused by DEN, as demonstrated by histopathology tests

GRAPHICAL ABSTRACT
The potential Two Types of Green Macroalgae (Caulerpa racemose and Caulerpa lentillifera) as a Natural Food Preservative from Jepara beach, Indonesia
Authors: Santosa Gunawan Widi , Djunaedi Ali , Susanto AB , Pringgenies Delianis , Ariyanto Dafit , Pranoton Aris Kabul
Published: April 2024

Green macroalgae, known locally as Latoh, is one of the green seaweeds consumed by the local community in Jepara and is beneficial for health. This study explores the potential of secondary metabolites from seaweed and its symbiotic bacteria as natural food preservatives and antibacterials. Seaweed samples were collected from the seagrass ecosystem of Panjang Island, Jepara, Indonesia. Subsequently, the samples were subjected to scanning electron microscopy analysis, proximate analysis, phytochemical analysis, thin layer chromatography, and high-performance liquid chromatography for amino acid analysis. A sample was subjected to a multistage extraction process using n-hexane, ethyl acetate, and methanol (1:5 w/v), each for 24 h. Symbiotic bacteria from seaweed were isolated, and enzymatic (proteolytic, amylolytic, and cellulolytic) and antibacterial testing against pathogenic bacteria Staphylococcus aureus and Escherichia coli was conducted using the disc diffusion method. The selected bacteria were subjected to molecular identification. The research showed that Caulerpa lentillifera had an ash content of 3.24 %, protein content of 0.57 %, and fat content of 0.337 %. Phytochemical analysis shows that the sample contains flavonoids, steroids, and alkaloids. HPLC analysis reveals that Caulerpa lentillifera has the highest content of aspartic acid (relative area: 11.90 %), glutamic acid (relative area: 13.43 %), and alanine (relative area: 9.03 %). Caulerpa racemosa sample shows the highest detector response for glutamic acid (relative area: 12.19%), aspartic acid (relative area: 11.10 %), and alanine (relative area: 9.63 %). The results indicate that 14 bacterial isolates were successfully isolated, with 6 isolates from Caulerpa lentillifera and 8 isolates from Caulerpa racemosa, all exhibiting enzymatic and antibacterial abilities. The research results concluded that the Latoh seaweed species Caulerpa lentillifera and Caulerpa racemosa and their symbiotic bacteria have the potential to be used as food preservatives.
HIGHLIGHTS   

HPLC analysis showed that Caulerpa lentillifera had the highest content of aspartic acid, glutamic acid, and alanine. Caulerpa racemosa also had high levels of glutamic acid, aspartic acid, and alanine
The research successfully isolated 14 bacterial isolates, with 6 isolates from Caulerpa lentillifera and eight isolates from Caulerpa racemosa, all exhibiting enzymatic and antibacterial abilities
Molecular identification revealed the presence of identified bacteria such as Pseudoalteromonas arabiensis, Pseudoalteromonas piscicida, Pseudoalteromonas shioyasakiensis, and Vibrio alginolyticus
seaweed species Caulerpa lentillifera and Caulerpa racemosa, along with their symbiotic bacteria, have the potential to be used as natural food preservatives due to their antibacterial and enzymatic pro perties

GRAPHICAL ABSTRACT
Anti-Inflammatory Effects of Moringa Oleifera Lam Leaf Extract in Lipopolysaccharide-Activated Microglia
Authors: Thampithak Anusorn , Karachot Busarat , Jantaratnotai Nattinee , Tuchinda Patoomratana , Sanvarinda Pimtip
Published: April 2024

Moringa oleifera Lam has been used as a medicinal plant in many Asian countries including Thailand. The plant has a variety of pharmacological effects such as antioxidant, anti-inflammation, hypolipidemic, anti-infection, anticancer, and antidiabetic. The leaves and young pods, which contain various nutritional compounds including proteins, fatty acids, and vitamins, are widely consumed. In this study, we investigated the effects of hexane, ethyl acetate, methanol and ethanol crude extracts of M. oleifera Lam leaves on the viability of microglial cells and on the lipopolysaccharide-induced microglial activation. which is widely used as a model for neuroinflammation. Our findings suggested that all of the crude extracts at concentrations ranging from 10–9 to 10–5 g/mL did not significantly affect the viability of microglial cells and exhibited similar effects. Subsequently, we focused on ethanol extract for investigation of the molecular mechanism involving neuroinflammation. We found that the ethanol extract of M. oleifera Lam leaves at the concentrations of 10–9 to 10–5 g/mL significantly reduced inducible nitric oxide synthase (iNOS) protein expression and nitric oxide (NO) production, accompanied by the reduction of phospho-NF-κB and phospho-IκBα expressions. The results suggested that the ethanol extract of M. oleifera Lam leaves reduced NO production through reduction of iNOS protein expression following the inhibition of NF-κB/IκBα signaling pathways. Our study underscored the therapeutic potential of M. oleifera Lam leaves extract in neurodegenerative diseases associated with neuroinflammation.
HIGHLIGHTS   

The ethanol extract of M. oleifera Lam leaves dose-dependently reduced NO production in LPS-activated microglia
The reduction in NO production correlated with the reduction in iNOS protein expression
The extract inhibited the expression of NF-kB/I-kBα protein expression in a dose-dependent manner
The ethanol extract of oleifera Lam leaves exhibited anti-inflammatory effect via the inhibition of NF-kB/I-kBα signaling pathway

GRAPHICAL ABSTRACT
Las murallas históricas de la ciudad de Oviedo, España
Authors: Fernández Molina José Ramón , Hevia González José Ramón
Published: April 2024

La intervención en el tramo de la calle Paraíso de la muralla de Oviedo ha permitido su recuperación y puesta en valor, dando a conocer ampliamente este Bien de Interés Cultural (declarado monumento histórico-artístico por Decreto de 3 de junio de 1931), indispensable para entender la propia conformación y evolución de la ciudad. Una ciudad cercada por un recinto murado a la que Alfonso II en el siglo IXtrasladó la corte de la monarquía asturiana, y desde la cual se iniciaría la primera peregrinación a Compostela para visitar el sepulcro recién descubierto del apóstol Santiago. Siglos más tarde, en plena Reconquista, Alfonso X ordenaría construir una nueva cerca. En el presente artículo se analiza la situación jurídica y patrimonial previa a la reciente intervención, las necesidades contractuales, así como la evolución de la fábrica, los tratamientos técnicos y las decisiones proyectuales adoptadas por el equipo pluridisciplinar comisionado, encabezado por el arquitecto José Ramón Fernández Molina.
i-WARM: Development of a Board Examination Reviewer Web Application for Filipino Pre-Service Physical Educators Utilizing the Unified Spaced Repetition and Hypercorrection Techniques
Authors: Almario John Ivan F. , Quiambao Angel S. , Sangalang Algenrev M. , Manlutac Abigail M. , Tolentino Julius Ceazar G. , Miranda John Paul P.
Published: April 2024

One of the major parameters by which college graduates' productivity is gauged is their board examination performance. Relevantly, the development and utilization of sophisticated tools and technology to facilitate reviews are encouraged and worthy of such exploration. The study aimed to develop an integrated web application reviewer for MAPEH (music, arts, physical education, and health) (i-WARM) with the use of unified spaced repetition and hypercorrection techniques. This descriptive research and development (R & D) design was used and employed a nine-step process in which functions were built for effective learning and retention of concepts. The evaluation was conducted by 106 graduating Bachelor of Physical Education students from a teacher education institution in Central Luzon, Philippines. Results revealed that the i-WARM is easy to use and easy to learn as it was viewed as clear and understandable, accessible, and has a flexible feature and interface. Pre-service physical educators perceived that the services provided by the web application are useful for their review as it was rated functional and informative. Frequent problems such as crashes and downtimes were not observed by the user during their exposure to the web application. The i-WARM could be explored as a potential aid in assisting learners to acquire concepts easily through an interactive interface. This may likewise assist teachers and students in establishing retention of significant concepts for future licensure examinations.
Project-Based Learning methodology (PBL) for the acquisition of Transversal Competences (TCs) and integration of Sustainable Development Goals (SDGs) in mechanical engineering subjects
Authors: Llopis-Albert Carlos , Rubio Francisco , Mata-Amela Vicente , Devece Carlos , Torner-Feltrer María Eugenia , Zeng Shouzhen
Published: April 2024

This research is carried out within the framework of a two-year Educational Innovation and Improvement Project (EIIP) to be implemented at the Universitat Politècnica de València (UPV) during the academic years 2023-2024 and 2024-2025. The project aims to design and apply a Project-Based Learning methodology (PBL) for a proper acquisition of Transversal Competences (TCs) and integration of the Sustainable Development Goals (SDGs) in a mechanical engineering subject that is taught in the first year of the master’s degree in Mechatronic Engineering from the School of Design Engineering. Based on an assessment by the teaching staff of the current situation and the aspects to be improved, this article explains how the PBL methodology will be applied and performs an analysis through surveys and personal interviews with the students of their level of knowledge regarding the TCs and the SDGs that are worked on in the subject at the beginning of the academic year. The results show the need to continue working in the project and implementing active teaching techniques, such as PBL methodologies, to achieve a more attractive and motivating subject, closer to the labour market and a sustainable society.
Industrial cluster and knowledge creation: a bibliometric analysis and literature review
Authors: Tarazona Raul , García-Hurtado Dayanis , Devece Carlos , Hoffmann Valmir Emil
Published: April 2024

The interaction between the development of industrial clusters and knowledge generation has become a fundamental element in driving innovation systems. Examining industrial clusters in knowledge creation terms is interesting for policymakers, investors, businesses and academia. This article provides a thematic and intellectual overview of the existing scientific literature on industrial clusters, their evolution and their relation with knowledge creation. The aim is to identify the scientific literature foundations in this area, different intellectual, conceptual and social structures, and trends in the research field. The study is a bibliometric analysis, whose results show that researchers’ topics of interest have considerably evolved over the last four decades. Initially, most studies focus on policies for efficient clusters management and later, starting in the 2010s, they evolve towards the importance of the networks of resources and knowledge that clusters provide, and how to promote learning and innovation as a key activity for economic development.