bluuebunny/crossref_metadata_2025 huggingface dataset:
Modulating the Unfolded Protein Response with ISRIB Mitigates Cisplatin Ototoxicity
Authors: Li Jiang , Rouse Stephanie L. , Matthews Ian R. , Sherr Elliott H. , Chan Dylan K.
Published: October 2023

Cisplatin is a commonly used chemotherapy agent with a nearly universal side effect of sensorineural hearing loss. The cellular mechanisms underlying cisplatin ototoxicity are poorly understood. Efforts in drug development to prevent or reverse cisplatin ototoxicity have largely focused on pathways of oxidative stress and apoptosis. An effective treatment for cisplatin ototoxicity, sodium thiosulfate (STS), while beneficial when used in standard risk hepatoblastoma, is associated with reduced survival in disseminated pediatric malignancies, highlighting the need for more specific drugs without potential tumor protective effects. The unfolded protein response (UPR) and endoplasmic reticulum (ER) stress pathways have been shown to be involved in the pathogenesis of noise-induced hearing loss and cochlear synaptopathyin vivo, and these pathways have been implicated broadly in cisplatin cytotoxicity. This study sought to determine whether the UPR can be targeted to prevent cisplatin ototoxicity. Neonatal cochlear cultures and HEK cells were exposed to cisplatin and UPR-modulating drugs, and UPR marker gene expression and cell death measured. Treatment with ISRIB, a drug that activates eif2B and downregulates the pro-apoptotic PERK/CHOP pathway of the UPR, was tested in anin vivomouse model of cisplatin ototoxicity and well as a head and neck squamous cell carcinoma (HNSCC) cell-based assay of cisplatin cytotoxicity. Cisplatin exhibited a biphasic, non-linear dose-response of cell death and apoptosis that correlated with different patterns of UPR marker gene expression in HEK cells and cochlear cultures. ISRIB treatment protected against cisplatin-induced hearing loss and hair-cell death, but did not impact cisplatin’s cytotoxic effects on HNSCC cell viability, unlike STS. These findings demonstrate that targeting the pro-apoptotic PERK/CHOP pathway with ISRIB can mitigate cisplatin ototoxicity without reducing anti-cancer cell effects, suggesting that this may be a viable strategy for drug development.
Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6 mice
Authors: Timonina Daria , Hormazabal Genesis V , Heckenbach Indra , Anderton Edward , Haky Lauren , Floro Ariel , Riley Rebeccah , Kwok Ryan , Breslin Stella , Ingle Harris , Tiwari Ritesh , Bielska Olga , Scheibye-Knudsen Morten , Kasler Herbert , Campisi Judith , Walter Marius , Verdin Eric
Published: October 2023

The role of sleep in systemic aging remains poorly understood, despite sleep’s essential function in preserving overall health and the prevalence of reduced sleep quality in modern society. Although reduced sleep correlates with an elevated risk of age-related diseases in humans, the mechanisms underlying this are unclear. In this study, we established a link between sleep and aging by demonstrating that disrupting sleep in C57BL/6 mice drives cellular senescence in the visceral adipose tissue. Sleep disruption also led to increased oxidative stress and DNA damage, both recognized triggers for senescence induction. Cellular senescence is implicated in numerous age-related conditions which are associated with insufficient sleep, such as cardiovascular disease, type 2 diabetes, and chronic inflammation. Our findings identify an accumulation of senescent cells in the adipose tissue, which serves as a potential target through which disturbed sleep accelerates the aging process and elevates the risk of age-related diseases.
The sensor of the bacterial histidine kinase CpxA is a novel dimer of extracytoplasmic Per-ARNT-Sim (PAS) domains
Authors: Cho Timothy H. S. , Murray Cameron , Malpica Roxana , Margain-Quevedo Rodrigo , Thede Gina L. , Lu Jun , Edwards Ross A. , Glover J. N. Mark , Raivio Tracy L.
Published: October 2023

Histidine kinases are key bacterial sensors that recognize diverse environmental stimuli. While mechanisms of phosphorylation and phosphotransfer by cytoplasmic kinase domains are relatively well-characterized, the ways in which extracytoplasmic sensor domains regulate activation remain mysterious. The Cpx envelope stress response is a conserved Gram-negative two-component system which is controlled by the sensor kinase CpxA. We report the structure of theEscherichia coliCpxA sensor domain (CpxA-SD) as a globular Per-ARNT-Sim (PAS)-like fold highly similar to that ofVibrio parahaemolyticusCpxA as determined by X-ray crystallography. Because sensor kinase dimerization is important for signaling, we used AlphaFold2 to model CpxA-SD in the context of its connected transmembrane domains, which yielded a novel dimer of PAS domains possessing a distinct dimer organization compared to previously characterized sensor domains. Gain of functioncpxA* alleles map to the dimer interface, and mutation of other residues in this region also leads to constitutive activation. CpxA activation can be suppressed by mutations that restore inter-monomer interactions, suggesting that inhibitory interactions between CpxA-SD monomers are the major point of control for CpxA activation and signaling. Searching through hundreds of structural homologues revealed the sensor domain ofPseudomonas aeruginosasensor kinase PfeS as the only PAS structure in the same novel dimer orientation as CpxA, suggesting that our dimer orientation may be utilized by other extracytoplasmic PAS domains. Overall, our findings provide insight into the diversity of the organization of PAS sensory domains and how they regulate sensor kinase activation.

Significance

Bacterial two-component systems play an essential role in sensing environmental cues, mitigating stress, and regulating virulence. We approach the study of a key Gram-negative sensor kinase CpxA with both classical methods in structural biology and genetic analysis and emerging protein-folding prediction software. This approach provides a wholistic perspective on the structure and function of histidine kinases as proteins with modular and cellular compartment-spanning domain architectures. We report a novel organization of PAS domains in CpxA, highlighting the versatility and diversity of this sensory fold. Ultimately, these studies will facilitate the continued development of novel antimicrobials against sensor kinases, including CpxA, which is a previously studied target for antimicrobials.
Scene-selective regions encode the vertical position of navigationally relevant information in young and older adulthood
Authors: Durteste Marion , Liebi Luca R. , Sapoval Emma , Delaux Alexandre , Arleo Angelo , Ramanoël Stephen
Published: October 2023

Position within the environment influences the navigational relevance of objects. However, the possibility that vertical position represents a central object property has yet to be explored. Considering that the upper and lower visual fields afford distinct types of visual cues and that scene-selective regions exhibit retinotopic biases, it is of interest to elucidate whether the vertical location of visual information modulates neural activity in these high-level visual areas. The occipital place area (OPA), parahippocampal place area (PPA) and medial place area (MPA) demonstrate biases for the contralateral lower visual field, contralateral upper visual field, and contralateral hemifield, respectively. Interesting insights could also be gained from studying older adulthood as recent work points towards an age-related preference for the lower visual field. In the present study, young and older participants learned the position of a goal in a virtual environment that manipulated two variables: the vertical position of navigationally-relevant objects and the presence of non-relevant objects. Results revealed that all three scene-selective regions parsed the vertical position of useful objects independently of their subtending retinotopic biases. It therefore appears that representations in the higher-level visual system combined information about vertical position and navigational value for wayfinding purposes. This property was maintained in healthy aging emphasizing the enduring significance of visual processing along the vertical dimension for spatial navigation abilities across the lifespan.
Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons
Authors: Bastille Isle , Lee Lucy , Moncada-Reid Cynthia , Yu Wei-Ming , Sitko Austen , Yung Andrea , Goodrich Lisa
Published: October 2023

Neurons develop diverse synapses that vary in content, morphology, and size. Although transcriptional regulators of neurotransmitter identity have been identified, it remains unclear how other synaptic features are patterned among neuronal subtypes. In the auditory system, glutamatergic synaptic properties vary across three subtypes of spiral ganglion neurons (SGNs) that collectively encode sound information. Here, we show that a combinatorial Maf transcription factor code establishes SGN subtype identity and shapes both shared and subtype-appropriate synaptic properties. We find thatc-MafandMafbhave independent and opposing effects on synaptic morphology and auditory function, while also acting redundantly to impart subtype identities and drive synaptic differentiation needed for normal auditory responses. Additionally,c-MafandMafbare expressed at different levels across subtypes and regulate subtype-appropriate gene expression in a dose-dependent manner. Thus, functional diversity of Maf family members enables flexible and robust control of gene expression needed to generate synaptic heterogeneity across neuronal subtypes.
Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos
Authors: Xiang Kehui , Ly Jimmy , Bartel David P.
Published: October 2023

During oocyte maturation and early embryogenesis, changes in mRNA poly(A)-tail lengths strongly influence translation, but how these tail-length changes are orchestrated has been unclear. Here, we performed tail-length and translational profiling of mRNA reporter libraries (each with millions of 3ʹ-UTR sequence variants) in frog oocytes and embryos, and fish embryos. We found that the UUUUA element, together with the polyadenylation signal (AAUAAA or AUUAAA), specifies cytoplasmic polyadenylation, and identified contextual features that modulate the activity of both elements. In maturing oocytes, this tail lengthening occurs against a backdrop of global deadenylation and the action of C-rich elements that specify tail-length-independent translational repression. In embryos, cytoplasmic polyadenylation becomes more permissive, and additional elements specify waves of stage-specific deadenylation. Together, these findings largely explain the complex tapestry of tail-length changes observed in early frog and fish development, with strong evidence of conservation in both mice and humans.

Highlights

UUUUA, modulated by contextual features, specifies most cytoplasmic polyadenylation

Stage-specific sequence motifs drive waves of tail-length shortening in embryos

UUUUA and C-rich motifs can direct tail-length-independent translational repression

Tail-length control is conserved in oocytes of frogs, mice, and humans
THE DUAL ROLE OF THEMICROCYSTIS AERUGINOSAMICROBIOME ON CYANOTOXIN PRODUCTION: COMPETITION FOR AND REMINERALIZATION OF ORGANIC NITROGEN
Authors: Li Wei , Baliu-Rodriguez David , Premathilaka Sanduni H. , Thenuwara Sharmila I. , Kimbrel Jeffrey , Samo Ty , Ramon Christina , Kiledal E. Anders , Rivera Sara R. , Kharbush Jenan , Isailovic Dragan , Weber Peter K. , Dick Gregory J. , Mayali Xavier
Published: October 2023

Nutrient-induced blooms of the globally abundant freshwater toxic cyanobacteriumMicrocystisare the cause of worldwide public and ecosystem health concerns. The response ofMicrocystisgrowth and toxin production to new and recycled nitrogen (N) inputs, and the impact of heterotrophic bacteria in theMicrocystisphycosphere on these processes are not well understood. Here, using microbiome transplant experiments, cyanotoxin analysis, and stable isotope tracing to measure N incorporation and exchange at single cell resolution, we monitored the growth, cyanotoxin production, and microbiome community structure of severalMicrocystisstrains grown on amino acids and proteins as the sole N source. We demonstrate that 1) organic N availability shapes the microbiome community structure in theMicrocystisphycosphere; 2) external organic N input leads to lower bacterial colonization of the phycosphere; 3) certainMicrocystisstrains can directly uptake amino acids, but with lower rates than heterotrophic bacteria; 4) biomass-specific microcystin production is not impacted by N source (i.e., nitrate, amino acids and protein) but rather by total N availability; and 5) some bacterial communities compete withMicrocystisfor organic N, but others remineralize organic N, in the process producing bio-available N forMicrocystis. We conclude that organic N input can supportMicrocystisblooms and toxin production, andMicrocystis-associated microbial communities play critical roles by influencing cyanobacterial succession through either decreasing (via competition) or increasing (via remineralization) N availability, especially under inorganic N scarcity.
Per- and polyfluoroalkyl substances concentrations are associated with an unfavorable cardio-metabolic risk profile: findings from two population-based cohort studies
Authors: Faquih Tariq O. , Landstra Elvire N. , van Hylckama Vlieg Astrid , Aziz N.Ahmad , Li-Gao Ruifang , de Mutsert Renée , Rosendaal Frits R. , Noordam Raymond , van Heemst Diana , Mook-Kanamori Dennis O. , Willems van Dijk Ko , Breteler Monique M.B.
Published: October 2023

Per- and polyfluoroalkyl substances (PFAS) are widely used and persistent chemicals, leading to ubiquitous exposure. Although high PFAS levels have been associated with an adverse cardiovascular risk profile, the distribution of levels and relations with cardio-metabolic risk markers in the general population have not been fully characterized. We assessed the association between blood levels of perfluorooctaneic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) and a range of lipoproteins and metabolites as well as clinical lipid measurements. We used data from participants of the Netherlands Epidemiology of Obesity study (NEO) (n= 584) and the Rhineland Study (n= 1,962), jointly spanning an age range of 30 to 89 years. PFAS were measured with the Metabolon HD4 platform, and lipoprotein and metabolite profiles were measured using Nightingale’s nuclear magnetic resonance-spectroscopy platform, and mainly comprised lipoprotein markers. Using linear regression analyses, we quantified age-, sex- and education-adjusted associations of PFOA, PFOS, and PFHxS with clinical lipid measurements and 224 lipoproteins and metabolites.

Higher levels of PFAS, particularly PFOS and PFHxS, were associated with higher concentrations of total lipid, cholesterol and phospholipid content in most HDL, IDL, LDL and VLDL subclasses. The effect sizes were age-dependent for the majority of the associations, with the deleterious effects of PFAS being generally stronger in people below compared to those above median age. Our observation that in the general population even low PFAS concentrations are associated with an unfavorable lipid profile, calls for further critical regulation of PFAS substances.
Association between common adverse events after COVID-19 vaccination and anti-SARS-CoV-2 antibody concentrations in a population-based prospective cohort study in the Netherlands
Authors: Holwerda M.R. , Hoeve C.E. , Huiberts A.J. , den Hartog G. , de Melker H.E. , Van den Hof S. , Knol M.J.
Published: October 2023

INTRODUCTION

Adverse events (AE) such as pain at injection site or fever are common after COVID-19 vaccination. We aimed to describe determinants of AE after COVID-19 vaccination and investigate the association between AE and pre- and post-vaccination antibody concentrations.

METHODS

Participants of an ongoing prospective cohort study (VASCO) completed a questionnaire on AE within two months after COVID-19 vaccination and provided 6-monthly serum samples. Data from May 2021 to November 2022 were included. Logistic regression analyses were performed to investigate determinants of AE after mRNA vaccination, including pre-vaccination Ig antibody concentrations against the receptor binding domain. Multivariable linear regression was performed in SARS-CoV-2 naïve participants to assess the association between AE and log-transformed antibody concentrations 3-8 weeks after mRNA vaccination.

RESULTS

47,947 AE questionnaires were completed by 28,032 participants. In 42% and 34% of questionnaires, injection site and systemic AE were reported, respectively. In 2.2% of questionnaires, participants sought medical attention due to AE. AE were reported significantly more frequently by women, younger participants (<60 years), participants with medical risk conditions and Spikevax recipients (versus Comirnaty). Higher pre-vaccination antibody concentrations were associated with higher incidence of systemic AE after the second and third dose, but not with injection site AE or AE for which medical attention was sought. Any AE after the third dose was associated with higher post-vaccination antibody concentrations (geometric mean concentration ratio: 1.38, 95%CI 1.23-1.54).

CONCLUSION

Our study suggests that high pre-vaccination antibody levels are associated with AE, and that experiencing AE may be a marker for a good antibody response to vaccination.
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
Authors: Alfeghaly Charbel , Castel Gaël , Cazottes Emmanuel , Moscatelli Madeleine , Moinard Eva , Casanova Miguel , Boni Juliette , Mahadik Kasturi , Lammers Jenna , Freour Thomas , Chauviere Louis , Piqueras Carla , Boers Ruben , Boers Joachim , Gribnau Joost , David Laurent , Ouimette Jean-François , Rougeulle Claire
Published: October 2023

XIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-accumulates with XIST on active Xs and may antagonize XIST function. Here we used human ES cells in a naïve state of pluripotency to assess the function of XIST and XACT in shaping the X chromosome chromatin and transcriptional landscapes during pre-implantation development. We show that XIST triggers the deposition of polycomb-mediated repressive histone modifications and attenuates transcription of most X-linked genes in a SPEN-dependent manner, while XACT deficiency does not significantly affect XIST activity or X-linked gene expression. Our study demonstrates that XIST is functional prior to XCI, confirms the existence of a transient process of X chromosome dosage compensation, and reveals that X chromosome inactivation and dampening rely on the same set of factors.
MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival
Authors: Hurd Matthew , Pino Jeffrey , Jang Kay , Allevato Michael M. , Vorontchikhina Marina , Ichikawa Wataru , Zhao Yifan , Gates Ryan , Villalpando Emily , Hamilton Michael J. , Faiola Francesco , Pan Songqin , Qi Yue , Hung Yu-Wen , Girke Thomas , Ann David , Seewaldt Victoria , Martinez Ernest
Published: October 2023

The MYC oncogenic transcription factor is acetylated by the p300 and GCN5 histone acetyltransferases. The significance of MYC acetylation and the functions of specific acetylated lysine (AcK) residues have remained unclear. Here, we show that the major p300-acetylated K148(149) and K157(158) sites in human (or mouse) MYC and the main GCN5-acetylated K323 residue are reversibly acetylated in various malignant and nonmalignant cells. Oncogenic overexpression of MYC enhances its acetylation and alters the regulation of site-specific acetylation by proteasome and deacetylase inhibitors. Acetylation of MYC at different K residues differentially affects its stability in a cell type-dependent manner. Lysine-to-arginine substitutions indicate that although none of the AcK residues is required for MYC stimulation of adherent cell proliferation, individual AcK sites have gene-specific functions controlling select MYC-regulated processes in cell adhesion, contact inhibition, apoptosis, and/or metabolism and are required for the malignant cell transformation activity of MYC. Each AcK site is required for anchorage-independent growth of MYC-overexpressing cells in vitro, and both the AcK148(149) and AcK157(158) residues are also important for the tumorigenic activity of MYC transformed cells in vivo. The MYC AcK site-specific signaling pathways identified may offer new avenues for selective therapeutic targeting of MYC oncogenic activities.
Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution
Authors: Gorelik Tatiana E. , Lukat Peer , Kleeberg Christian , Blankenfeldt Wulf , Mueller Rolf
Published: October 2023

The resolution of 3D electron diffraction (ED) data of small-molecule crystals is often relatively poor, due to either electron-beam radiation damage during data collection or poor crystallinity of the material. Direct methods, used as standard for crystal structure determination, are not applicable when the data resolution falls below the commonly accepted limit of 1.2 Å. Therefore an evaluation was carried out of the performance of molecular replacement (MR) procedures, regularly used for protein structure determination, for structure analysis of small-molecule crystal structures from 3D ED data. In the course of this study, two crystal structures of Bi-3812, a highly potent inhibitor of the oncogenic transcription factor BCL6, were determined: the structure of α-Bi-3812 was determined from single-crystal X-ray data, the structure of β-Bi-3812 from 3D ED data, using direct methods in both cases. These data were subsequently used for MR with different data types, varying the data resolution limit (1, 1.5 and 2 Å) and by using search models consisting of connected or disconnected fragments of BI-3812. MR was successful with 3D ED data at 2 Å resolution using a search model that represented 74% of the complete molecule.
Synthesis, crystal structure and thermal properties of poly[[μ-1,2-bis(pyridin-4-yl)ethene-κ2
N:N′-μ-bromido-copper(I)] 1,2-bis(pyridin-4-yl)ethene 0.25-solvate]
Authors: Näther Christian , Müller-Meinhard Asmus , Jess Inke
Published: October 2023

The reaction of copper(I) bromide with 1,2-bis(pyridin-4-yl)ethene in acetonitrile leads to the formation of the title compound, {[CuBr(C12H10N2)]·0.25C12H10N2}
n
or CuBr(4-bpe)·0.25(4-bpe) [4-bpe = 1,2-bis(pyridin-4-yl)ethene]. The asymmetric unit consists of one copper(I) cation and one bromide anion in general positions as well as two crystallographically independent half 4-bpe ligands and a quarter of a disordered 4-bpe solvate molecule that are completed by centers of inversion. The copper(I) cations are tetrahededrally coordinated as CuBr2N2 and linked by pairs of μ-1,1-bridging bromide anions into centrosymmetric dinuclear units that are further connected into layers by the 4-bpe coligands. Between the layers, interlayer C—H...Br hydrogen bonding is observed. The layers are arranged in such a way that cavities are formed in which the disordered 4-bpe solvate molecules are located. Powder X-ray (PXRD) investigations reveal that a pure sample has been obtained. Thermogravimetric (TG) and differential thermoanalysis (DTA) measurements show two mass losses that are accompanied by endothermic events in the DTA curve. The first mass loss correspond to the removal of 0.75 4-bpe molecules, leading to the formation of (CuBr)2(4-bpe), already reported in the literature as proven by PXRD.
Crystal structure and supramolecular features of a bis-urea-functionalized pillar[5]arene
Authors: Vinodh Mickey , Alipour Fatemeh H. , Al-Azemi Talal F.
Published: October 2023

The crystal structure of a bis-urea derivative based on A1/A2-functionalized pillar[5]arene (DUP) that encapsulates dimethyl formamide (DMF) inside the macrocyclic cavity is reported. The crystal structure of DUP·DMF, C63H70N4O12·C3H7NO, reveals that out of two urea functionalized spacers, one arm is oriented above the macrocyclic cavity with strong hydrogen-bonding interactions between the urea H atoms and DMF guest, whereas, the other arm is positioned away from the macrocycle, leading to intermolecular hydrogen-bonding interactions between the urea H atoms of two adjacent pillar[5]arene macrocycles, resulting in the formation of a supramolecular dimer.
Poly[bis(O-ethylhydroxylaminium) [di-μ-chlorido-dichloridocadmate(II)]]
Authors: Tong Yu-Qiao , Lei Zi-Qiong , Huang Bo
Published: October 2023

The title compound, {(CH3CH2ONH3)2[CdCl4]}
n
, consists of bilayers of organic CH3CH2ONH3
+ cations and infinite [CdCl4]
n

2n− inorganic layers. It can be described as an organic–inorganic hybrid layered perovskite. In the crystal structure, the CdII cation is situated at an inversion center and is coordinated by six chloride ions, forming a slightly distorted octahedral coordination polyhedron. By corner-sharing of the [CdCl6] octahedra, infinite [CdCl4]
n

2n− inorganic layers are formed, extending parallel to (100). The inorganic layers alternate with bilayers of CH3CH2ONH3
+ cations, whereby the connection of the cationic and anionic layers is achieved through N—H...Cl hydrogen bonds and Coulombic interactions.
Identifying characterizations of BPM methodology in hotel industry: evidence from listed hotel companies in Egypt
Authors: Moussa Mohamed Hany B. , Sayed M.S. , Allam Batta R.
Published: October 2023

Purpose

The purpose of this study is to identify the characterizations of business process management (BPM) methodology in hotel industry through an aggregate processing of the core cyclesteps (CCCs) of the highly-cited BPM life-cycle models in the literature aiming to highlight the major issues of the current methodological approach of BPM in hotels when to put the notion of service process into practice.

Design/methodology/approach

The paper identifies and examines the most popular BPM life-cycles models in the literature and locates 15 life-cycles that are highly cited. The paper then focuses on applying the theory on nine listed hotel companies in Egypt using a questionnaire in the form of a semi-structured interview technique.

Findings

The CCSs of BPM life-cycle model applied in hotels revealed a gap between BPM theory and practice in this sector. Utilizing this model of BPM life-cycle, the paper focuses on describing several of the main problems or pitfalls found in the methodological approach of BPM in hotels, which brings the essence of the whole operation management problems.

Practical implications

In light of these findings, the paper discusses the practical implications and focuses on recommendations on how to properly improve the methodological approach of BPM in hotels in order to get better business results.

Originality/value

The paper bridges the gap between BPM theory and practice and suggests recommendations that will assist hotel companies to eliminate the problems of poor process management (PM). There are also future research recommendations to enhance the knowledge of BPM theory in the service sector.
The airfoil design and parameter optimization of the deformable micro air vehicle
Authors: Huang Shengxian , Qiu Huihe , Wang Ying
Published: October 2023

Purpose

Since most of the existing literature do not disclose the node coordinate data of its fixed-wing aircraft airfoil, in order to develop and obtain a practical and suitable deformation airfoil for fixed-wing micro air vehicle (MAV), this paper proposes an improved airfoil design method of fixed-wing MAV based on the profile data of S5010 airfoil.

Design/methodology/approach

Combined with the body shape variation of the stingray in the propulsion process, the parametric study of the aerodynamic shape of the original design airfoil is carried out to explore the influence of a single parameter change on the aerodynamic performance of the airfoil. Then, according to the influence law of single parameter variation on the aerodynamic performance of the airfoil, the original airfoil is synthetically deformed by changing multiple parameters.

Findings

By comparing the aerodynamic performance of the multi-parameter deformed airfoil with the original airfoil, it is found that the lift coefficient of the multi-parameter deformed airfoil changes from negative to positive value when AOA = 0°. When AOA = 2°, the lift coefficient growth rate is the largest, which is 47.27%, and the lift-to-drag ratio is increased by 50.00%. At other angles of attack, the lift, drag, and torque coefficients of the multi-parameter deformed airfoil are optimized to some extent.

Originality/value

Combined the body shape variation of the stingray in the propulsion process, the parametric study of the aerodynamic shape of the original design airfoil is carried out to explore the influence of a single parameter change on the aerodynamic performance of the airfoil.
What hinders the implementation of carbon emission reduction in the construction industry: evidence from integrated multi-criteria decision-making in China
Authors: Li Junjie , Zhang Jiaying , Liu Chunlu , Luo Xiangyun
Published: October 2023

Purpose

This research paper aims to establish a comprehensive framework for the barriers to CER in the construction industry, assesses the barriers' relative degrees of hindrance and causal mechanisms.

Design/methodology/approach

Firstly, 26 carbon emission reduction (CER) barriers in the construction industry were identified based on a systematic literature review (SLR) and categorized into five dimensions: policy, economy, society, technology and organization (PEST + O model). Secondly, the Best–Worst Method (BWM) was used to clarify the degrees of hindrance of the CER barriers. Then, the Grey-Decision-Making Trial and Evaluation Laboratory (Grey-DEMATEL) was used to visualize the directional cause–result relationship network among prominent barriers. Finally, the Boston matrix model was used to propose differentiated strategies to address CER barriers in the construction industry.

Findings

The calculated centrality and causality of the prominent barriers indicated that the lack of relevant legal policies and normative guidelines, the poor binding force and enforcement of existing relevant policies, the lack of effective economic subsidies and incentives and the difficulty in the operation, transformation and upgrading of existing construction CER are the key barriers that CER needs to address first in the construction industry. Considering the order of priority and the optimal path, differentiated countermeasures are proposed to address key, driving, independent and effect barriers.

Originality/value

This study develops a BWM–Grey-DEMATEL integrated multi-criteria decision-making model. An innovative C-shaped strategic map for addressing CER barriers in the construction industry is proposed by integrating the dual dimensions of time and space. This will guide practitioners, policymakers and decision-makers in developing CER strategies.
Covering Número 85: a content analysis and critical race theory perspective
Authors: Virella Patricia
Published: October 2023

Purpose

Narratives about racism and equity in schools have been documented in varying degrees of detail and accuracy in the news media (Farhi, 2012). Thus, race is front and center in the news reports, demonstrating how education policies are detrimental to the Island while also contending that policy drivers of Ley de Reforma Educativa de Puerto Rico (LREPR) are ignoring the racialized consequences of these neoliberal policies.

Design/methodology/approach

To examine the implementation of LREPR in education discourse in the media, a content analysis on texts in the Puerto Rican media was conducted. To conduct the analysis, an original dataset of texts from the four major newspapers in Puerto Rico: El Nuevo Dia, El Vocero, Primera Hora and The San Juan Daily Star (n = 119) was created.

Findings

The study shows how the collective resistance of Puerto Ricans towards LREPR suggests racialized consequences for this “post”-colonial Island as they engage in dialogues about property rights and dispute policy discourse. Data suggests the alarming effects of neoliberalism as perceived by Puerto Rican citizens, while highlighting shared concerns aligned with elements of critical race theory such as colorblindness and property rights.

Research limitations/implications

This study breaks ground by identifying a new intellectual pursuit of charter schools purchasing land or buildings in marginalized communities. It argues that the news coverage demonstrates how Puerto Rican citizens have illuminated the purchase of land for charter schools, viewing it as an act of colonialism veiled as market competition and economic improvement for the Island. Implications for policy and practice are discussed.

Originality/value

The findings from this research contribute to how critical race theory is used and conceptualized in the educational leadership field. Additionally, the study contributes to the field of research by conducting a content analysis of newspaper articles in Puerto Rico, looking through the CRT lens to illuminate systemic racism that is present in media accounts of education.
Robotic service quality, authenticity, and revisit intention to restaurants in China: extending cognitive appraisal theory
Authors: Song Hanqun , Yang Huijun , Sthapit Erose
Published: October 2023

Purpose

Using cognitive appraisal theory, this study aims to propose and test an integrated framework – comprising robotic service quality, robotic service authenticity, customer existential authenticity and customer revisit intention – on diners with experience using robotic technology in restaurants. The moderating role of robotic appearance is in the hypothesised relationship.

Design/methodology/approach

Data was gathered through a Web-based survey delivered to 428 diners who had experience using robotic services in restaurants in China. The hypotheses were analysed using a structural equation model and multi-group analysis was used to analyse the moderating effect.

Findings

The findings indicate that functional service quality positively influences robotic service authenticity and existential authenticity. However, technical service quality only affects existential authenticity, which leads to revisit intention. Robotic appearance moderated the relationship between functional service quality and service authenticity.

Research limitations/implications

Restaurateurs should enhance robotic service authenticity, existential authenticity and revisit intention by improving robotic technical service collaborating with robot manufacturers and operators.

Originality/value

Focusing on cognitive appraisal theory, the findings serve as a starting point for investigating robotic service quality and authenticity in robotic service settings theoretically and empirically.
The impact of peer mentoring in first-year education students
Authors: Lapon Elizabeth , Buddington Leslie
Published: October 2023

Purpose

The transition to college presents significant challenges for many students as they navigate new academic and social experiences. In the USA, 30% of first-year students drop out before their second year. Research indicates that mentoring programs help students achieve social integration and likely have a positive effect on their transition to college. This research study was conducted with education students to better understand the potential impacts of peer mentorship.

Design/methodology/approach

Student mentors and mentees were matched by attributes such as their concentration within the education major, gender, sports they played and whether they were first-generation matriculants. Data collection utilized two surveys one before the peer mentoring process and one after the process.

Findings

The findings suggest that peer mentoring improved first-generation students' sense of belonging to both their major and the college. Peer mentors also experienced increased belongingness. The transfer rate among participants of 2% was a significant drop from previous years.

Originality/value

The success of the peer mentoring experience was possibly due to the intentional matching process based on certain attributes. Additionally, taking a leadership role increased a sense of belonging in the peer mentors.
Predisposing, need and enabling factors for service utilization amongst newly arrived youth in Sweden
Authors: Nystrand Camilla , Osman Fatumo , Lindell Charles , Olsson Frida , Durbeej Natalie
Published: October 2023

Purpose

The reasons for and experiences during migration, as well as additional stressors in the new host country, may give rise to mental health problems and additional need for public services. The purpose of the study was to investigate factors related to service utilization among newly arrived refugee youth.

Design/methodology/approach

Cross-sectional data were gathered in Sweden where 37 youth aged between 19 and 23 reported on factors related to service utilization, encompassing health-care and support services in school. These factors included predisposition (demographic), need (migration status and mental wellbeing) and enablement (living situation). Service utilization was estimated using multiple logistic regression analysis.

Findings

About a fourth of the sample used psychosocial services. Use of general support was more common. Neither predisposing, need nor enabling factors were associated with the use of psychosocial or general health-related services.

Originality/value

Self-reported factors related to use of health-related services have previously not been investigated for refugee youth, which is important in assuring access to appropriate services for this exposed youth population.
The influence of e-satisfaction on users' e-loyalty toward e-wallet payment apps: a mediated-moderated model
Authors: Al-Okaily Manaf
Published: October 2023

Purpose

The purpose of this study is to investigate the antecedent factors influencing e-loyalty toward e-wallet payment apps in developing countries (e.g. Jordan). This study also investigates the mediating role of perceived usefulness (PU) and the moderating role of electronic word of mouth (e-WOM) toward these apps.

Design/methodology/approach

An online questionnaire was used for data collection from 251 actual users of e-wallet payment apps. To estimate and test the research-proposed model, the partial least squares structural equation modeling (PLS-SEM) was employed.

Findings

The results mainly confirm that perceived trust (PT), perceived financial cost (PFC) and perceived ease of use were found to be determinants of PU; perceived security (PS), PT, PFC, perceived ease of use and perceived enjoyment (PE) were found to be determinants of e-satisfaction, whereas e-satisfaction and e-WOM were found to be determinants of e-loyalty toward e-wallet payment apps. Likewise, the results support the significant effect of the moderating effect of e-WOM. Conversely, the direct and indirect impact of PU and perceived health benefits (PHB) on e-satisfaction is not supported; therefore, hypotheses H4, H5 and H9 were rejected.

Originality/value

This study contributes to the understanding of the critical success factors underlying e-wallet apps during and post-COVID-19 era, which can help policymakers in banks and other financial institutions (service providers) to increase the diffusion rate of financial inclusion by the usage of e-wallet apps.
A multiobjective mathematical model for a humanitarian logistics multimodal transportation problem
Authors: Romero-Mancilla Marisol S. , Hernandez-Ruiz Kenneth E. , Huerta-Muñoz Diana L.
Published: October 2023

Purpose

The purpose of this paper is to introduce a three-echelon multimodal transportation problem applied to a humanitarian logistic case study that occurred in Mexico.

Design/methodology/approach

This study develops a methodology combining a transshipment problem and an adaptation of the multidepot heterogeneous fleet vehicle routing problem to construct a mathematical model that incorporates the use of land-based vehicles and drones. The model was applied to the case study of the Earthquake on September 19, 2017, in Mexico, using the Gurobi optimization solver.

Findings

The results ratified the relevance of the study, showing an inverse relationship between transportation costs and delivery time; on the flip side, the model performed in a shorter CPU time with medium and small instances than with large instances.

Research limitations/implications

While the size of the instances limits the use of the model for big-scale problems, this approach manages to provide a good representation of a transportation network during a natural disaster using drones in the last-mile deliveries.

Originality/value

The present study contributes to a model that combines a vehicle routing problem with transshipment, multiple depots and a heterogeneous fleet including land-based vehicles and drones. There are multiple models present in the literature for these types of problems that incorporate the use of these transportation modes; however, to the best of the authors’ knowledge, there are still no proposals similar to this study.
Evaluation of a virtual placement for mental health nursing students: a pilot study
Authors: Brook Judy , Kemp Charlotte , Abbott Stephen
Published: October 2023

Purpose

Large numbers of nursing students and the COVID-19 pandemic made it necessary to relieve the pressure on UK hospitals to host clinical placements. One hospital innovated by providing a virtual placement online, immediately before an in-person placement. The purpose of this study is to evaluate the participant responses to the online virtual placement.

Design/methodology/approach

This was a pilot study evaluated after the placement, including a student survey (25 responses), four semi-structured interviews with students and four with staff in spring 2021.

Findings

High levels of approval of the innovation were recorded among both students and staff. Students were pleased to be taught by clinical experts, though some found it difficult to study at home and some found the hours long. High satisfaction levels may reflect the pandemic context: the placement reduced social isolation and the sense of education being interrupted. Participating students were in their final year of study, and the placement took place in the second year of the pandemic, so mutual familiarity and well-developed information technology skills may have made the innovation more acceptable.

Practical implications

The innovation has value and should be maintained post-pandemic to increase mental health in-person placement capacity and scaffold student learning.

Originality/value

This study added new knowledge to understanding about the utility of virtual placements in mental health nursing education.
Arbitrators’ suspicion of money laundering: choices against principles
Authors: Alkhayer Jaffar Yakkop , Gupta Chander Mohan
Published: October 2023

Purpose

This paper aims to examine the options available to arbitrators when they suspect money laundering during arbitration proceedings, considering their compatibility with fundamental principles and concepts of arbitration.

Design/methodology/approach

Using a doctrinal analysis approach, the paper draws on legal principles, antimoney laundering regulations and relevant literature to explore the topic. It considers relevant international treaties, standards set by the financial action task force on money laundering, cases and arguments from legal analysts and experts.

Findings

The paper identifies three options for arbitrators: disregarding suspicions, initiating an investigation or terminating the proceedings. Disregarding suspicions is deemed inappropriate, as it may facilitate the concealment of financial crimes. Initiating an investigation is seen as a preferable option, aligning with the arbitrator’s role and the public interest in nullifying contracts linked to criminal conduct. Terminating the proceedings is not recommended, as it contradicts the principle of natural justice. The paper emphasizes the importance of reasonable grounds for suspicions, notifying the parties, and allowing them to address the concerns.

Originality/value

This paper contributes to the existing literature by comprehensively analyzing the compatibility of these options with arbitration principles and concepts. It underscores the need for clear laws and directives to guide arbitrators in addressing financial crimes within the arbitration process, maintaining a balance between party autonomy and preventing the misuse of arbitration for illicit activities.
Should I stay or move on—examining the roles of knowledge sharing system, job crafting, and meaningfulness in work in influencing employees' intention to stay
Authors: Malik Parul , Malik Pooja
Published: October 2023

Purpose

Based on the affective events and self-concept theories, this study aims to examine the relationship between knowledge sharing system, job crafting, meaningfulness in work and employees' intention to stay with the organization.

Design/methodology/approach

In the present study, the authors conducted a time-lagged survey for analyzing the association between knowledge sharing system, job crafting, meaningfulness in work and employees' intention to stay with the organization. The study sample comprises 358 Generation Y employees working in Indian IT organizations. Results were analyzed using Process and Hayes macro process.

Findings

The study findings suggest significant relationships between knowledge sharing system, job crafting, meaningfulness in work and intention to stay among Gen Y employees. Moreover, the results demonstrated that knowledge sharing system, directly and indirectly, impacts employees' intention to stay via sequential mediation of job crafting and meaningfulness in work.

Practical implications

In today's era of hyper-competition and “war for talent,” retaining talented professionals has become the topmost priority for organizations. This becomes even more challenging with new generations, Gen Y and Z, entering the workforce driven by entirely different needs compared to earlier generations. Thus, the present study offers an integrated framework that organizational practitioners could utilize to enhance the retention of their young talented professionals.

Originality/value

Despite the emerging interest in the concept of knowledge sharing, few studies investigated the association between knowledge sharing system and intention to stay among Gen Y employees. Also, research still lacks in examining the underlying mechanism of how knowledge sharing system may enhance job crafting and meaningfulness in work, which could fuel Gen Y employees' intention to stay with the organization.