bluuebunny/crossref_metadata_2025 huggingface dataset:
NITROSYL FERREDOXINES MIMETICS AS PHOSPHODIESTERASE INHIBITORS: SYNTHESIS, STRUCTURE AND ACTIVITY IN VITRO
Authors:   FGBUN Institute for Chemical Physics at the Russian Academy of Sciences (IPHF RAS), Sanina Natalia
Published: December 2021

The paper presents and discusses experimental data on the synthesis, study of the structure and properties in the solid phase and in solutions of new low-molecular-weight iron dinitrosyl complexes with N,S-ligands of the 1,2,4 -1-H-triazole N,S-ligands of the“g = 2.03” family, nitric oxide (NO) donors, and effective inhibitors of cGMP phosphodiesterases.
BIOCHEMICAL PREDICTORS OF EARLY AND LONG-TERM OUTCOMES OF TRAUMATIC BRAIN INJURY IN CHILDREN
Authors:   Scientific Medical Research Center of Children's Health, Sorokina Elena , Semenova Zhanna ,   Research Institute of emergency pediatric surgery and trauma, Lukianov Valery Ivanovich ,   Research Institute of emergency pediatric surgery and trauma, Karaseva Olga ,   Research Institute of emergency pediatric surgery and trauma, Afanasieva Sofya A. ,   Scientific Medical Research Center for Children's Health, Reutov Valentin ,   Institute of Higher Nervous Activity and Neurophysiology RAS, Roshal Leonid Michailovich ,   Research Institute of emergency pediatric surgery and trauma, Pinelis Vsevolod Grigorievich ,   Scientific Medical Research Center of Children's Health
Published: December 2021

In children with mild and severe traumatic brain injury (TBI), the role of various damage/repair neuromarkers in the outcomes of trauma was studied. It has been shown that in the first days after TBI with adverse outcomes, there was a significant increase in NSE, S100b, NO products and a decrease in the content of BDNF and autoantibodies to NMDA (NR2) glutamate receptors (Glu) in the blood serum. After 6 months with unfavorable outcomes, there was an increase in aAb to S100b and a decrease in BDNF.
DISCOVERY OF RUSSIAN ORIGINAL CLASS III ANTIARRHYTHMIC DRUGS: FROM ACTIVE INGREDIENT TO PHARMACEUTICAL FORM
Authors:   A.N. Nesmeyanov Institute of Organoelement Com-pounds Russian Academy of Sciences (INEOS RAS), Davydova Nadejda
Published: December 2021

This paper summarizes data on research and development of Russian original class III anti-arrhythmic drugs.
MICROSTRUCTURAL INDICATORS OF MUSCLE TISSUE WITH VARYING DEGREES OF SEVERITY OF MYOPATHY SIGNS IN FASTGROWING PIGS
Authors:   Federal Research Center for Food Systems named af-ter V.M. Gorbatov RAS, Nasonova Victoria V. , Semenova Anastasia A. ,   Federal Research Center for Food Systems named af-ter V.M. Gorbatov RAS, Kuznetsova Tatyana G. ,   Federal Research Center for Food Systems named af-ter V.M. Gorbatov RAS, Nekrasov Roman V. ,   Federal Research Center for Animal Husbandry named after Academy Member L.K. Ernst
Published: December 2021

The article presents the criteria for determining the severity of myopathy by assessing the morphological features of muscle tissue. Since it is known that hybrid pigs are most susceptible to stress, which further leads to the development of dystrophic (myopathic) changes in the structure of muscle tissue, which subsequently reduce the quality of pork.
FLUORESCENT POLARIZATION IMMUNOASSAY OF MICROCYSTIN-LR
Authors:   A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Hendrickson Olga Dmitrievna , Zvereva Elena Anatolievna ,   A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Maksimova Ksenia Alekseevna ,   A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Bondarenko Alexandra Pavlovna ,   A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Eremin Sergey Aleksandrovich ,   A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences
Published: December 2021

To control the highly toxic phycotoxin microcystin-LR, which comtaminates food, a test sys-tem based on polarizing fluorescent immunoassay has been developed allowing for rapid screening testing, the detection limit of microcystin-LR is up to 7.5 ng / ml; duration of analy-sis – 10 min.
ISSUES OF ENSURING THE SAFE USE OF TECHNOLOGICAL MICROORGANISMS IN THE FOOD INDUSTRY
Authors:   Federal research centre of nutrition and biotechnology, Bagryantseva Olga V. ,   First Moscow State Medical University named after I.M. Sechenov, Sheveleva Svetlana A. ,   Federal research centre of nutrition and biotechnology
Published: December 2021

The article provides the substantiation of the requirements for the safe use of technological microorganisms in the production of food.
A Conceptual Study on Performance of Small-Scale Industries in India
Authors: B. S. Shashank , Mayya Sureshramana
Published: December 2021

Purpose: Small-Scale Industries (SSI) are critical to economic development, particularly in developing countries. SSI provide nearly forty percent of the gross industrial value added to the Indian economy. It is interesting to know the performance and status of small-scale industries by using data from the Ministry of Micro, Small, and Medium Enterprises (MSME) and analysing the SSI's strengths, weaknesses, threats, and opportunities.
Objective: This research aims to analyse the scheme introduced by the Government to improve the SSI output.
Methodology: For the study, we considered various articles, websites and tabular presentations.
Result: According to the study, government schemes and policies contribute to promoting SSI growth in India. SSI provides a more significant contribution to the country's export, and it creates more employment opportunities for youth.
Originality/value: The study determined the efficiency of small-scale industries in terms of unit establishment, production, job creation and export and also learned about some special government facilities provided through various schemes and programmes to address issues or problems and promote SSI's growth and development.
Paper type: Research Case Study.
Preface
Authors: Nijhuis Steffen , Bertram Christian , Somer Kees
Published: December 2021

to the theme issue 'Estate Landscapes'
Dutch research into the country house and its landscape
Authors: Ronnes Hanneke
Published: December 2021

One of the unmistakable trends in current country house research is the growing interest in the landscape context of country houses. The unquestioned emphasis on the main house and the garden is increasingly giving way to an approach that includes or focuses on the wider setting: village, nature, town, infrastructure, farms, churches, and other country houses. This article sketches the rise of this approach and offers an overview of the various perspectives. Among the aspects covered by landscape studies are country house regions, choice of location, the productive landscape, infrastructure, the political landscape and the mental landscape. Although this growing interest in the landscape setting is one of the most important recent developments in country house research, most of these studies are predominantly descriptive. This article calls for the establishment of a firmer methodological and theoretical underpinning – a task to which it is to be hoped that future researchers will devote themselves.
Estate landscapes in Gelderland
Authors: Thissen Paul
Published: December 2021

The Province of Gelderland has long boasted a large number of country houses and landed estates, which over time coalesced into estate landscapes around the historical capitals of the Duchy of Guelders quarters of Nijmegen, Arnhem and Zutphen.

Rapidly increasing urbanization from the end of the nineteenth century onwards threatened the coherence and accessibility of these landscapes. Gelderland’s largest cities, Arnhem and Nijmegen, watched in dismay as many country houses and landed estates fell victim to subdivision and development. In response they started to buy up portions of that estate landscape to ensure that they would remain available to city dwellers. In addition, the ‘safety net’ provided by newly established nature and landscape organizations, in particular Natuurmonumenten and Geldersch Landschap & Kasteelen, also contributed to preservation and permanent accessibility by offering landed families the opportunity to keep their estate intact, albeit no longer under their ownership.

Similar motives – the need to preserve attractive, accessible walking areas for the increasingly urbanized society – underpinned the government’s introduction of the Nature Conservation Act in 1928. The Act was invoked more frequently in Gelderland than in any other province. It promoted the opening up of private properties as well as the preservation of the cultural value of the kind of ‘natural beauty’ to be found on landed estates.

After the Second World War, in addition to resorting to the Nature Conservation Act, the owners of country houses and landed estates could avail themselves of an increasing variety of grants aimed at preserving (publicly accessible) nature, landscape and heritage, although the emphasis was firmly on nature. Estate landscapes like the Veluwezoom and the County of Zutphen were eventually safeguarded by a patchwork of different government regulations.

In the twenty-first century, government policy shifted towards providing financial support for both public and private contributions to nature, landscape and heritage by country houses and landed estates. This in turn has stimulated interest in estate landscapes. Instead of individual heritage-listed estates, the focus is now on areas with multiple country house and landed estates where there are spatial tasks waiting to be fulfilled: not just the preservation of natural beauty for outdoor recreation, but also spatial articulation, climate change adaptation, increased biodiversity and sustainable agriculture. Interest in design, both past and present, has burgeoned thanks to this development.
Future-proofing estate landscapes
Authors: Nijhuis Steffen
Published: December 2021

Climate change and urbanization have substantial ramifications for the management and protection of cultural-historical landscapes. This is especially true for historical estate landscapes – landscapes whose character is defined by several historical castles, country houses (along with their gardens and parks), and landed estates – where climate change adaptation constitutes a major task. Issues of concern include an excess or shortage of water and changes to vegetation as a result of rising temperatures. That pressure is compounded by increasing urbanization and the associated recreational needs. These landscapes are also susceptible to spatial fragmentation due to urbanization, changes in ownership, changes in function, and so on. Combatting these pressures calls for a future-oriented design approach that deals sensitively with historically valuable landscape characteristics. It involves safeguarding the spatial quality of estate landscapes by striking a new balance between utility value (economic exploitation), amenity value (identity and familiarity), and future value (ecological sustainability). Such is the complexity of the task that a regional perspective is required in order to fully comprehend the cohesion and systemic relations between individual country estates and to develop a common basis for collaboration.

This article proposes a landscape-based regional design approach aimed at understanding and designing future-proof estate landscapes. It details a preservation-through-development strategy based on spatial development in sympathy with historical landscapes structures in a process of meaningful stakeholder involvement. Key to this process is collaboration and co-creation with owners, experts, policy advisers and others. Design-based research is employed as a method for addressing the complex spatial tasks facing estate landscapes in an integrated and creative manner. Spatial design, at every level of scale, becomes a instrument for working out development strategies and principles for context-specific landscape formation. But also for highlighting possible solutions that can contribute to the protection and development of historical estate landscapes. In other words, this is not about opposing change or locking up the existing landscape, but about creating new landscape qualities through well-designed new developments. This coincides with a collaborative process in which stakeholders jointly weigh the pros and cons, learn and come up with solutions. The combination of substance, involvement and process makes the landscape-based regional design approach a powerful method for increasing the resilience and adaptability of the estate landscape and in so doing making this landscape future-proof.
Tuinarchitect Lucas Pieters Roodbaard (1782-1851) en de landschapsstijl
Authors: Bertram Christian
Published: December 2021

Book review of a book written by Rita Radetzky
Studies on Preparation and Evaluation of Soluble 1:1 Stoichiometric Curcumin Complex for Colorectal Cancer Treatment
Authors: Mohamed Jamal Moideen Muthu , Ahmad Fazil , Alqahtani Ali , Lqahtani Taha , Raju Venkatesan Krishna , Anusuya M
Published: December 2021

This study investigates the complex of curcumin (CMN), which has enhanced solubility and hence, higher cytotoxicity compared to free CMN. Insilco molecular modelling and phase solubility (PS) studies were performed with the drug and carriers for interaction. The complex was characterized by in vitro drug release, FT-IR, PXRD, TGA, DSC, SEM, DLS, and functionalized dyeing test. The result showed that the CMN-PEG6000 complex produced significant properties of solubility (≈ 190 folds) and dissolution (80.68 % at 30 min), with stability constants equivalent to 309 and 377 M-1 at 25 and 37 °C, respectively. It exhibited AL type of isotherm indicating 1:1 stoichiometry. The result from the in vitro cytotoxicity showed that 50 % inhibition (IC50) was achieved on the SW480 and Caco-2 cells at an amount of complex that was considerably lesser than free CMN. Apoptosis study showed that the cells underwent cell death mainly by apoptosis with a small number by necrosis.

HIGHLIGHTS

Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated

The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 °C, respectively

First time of novel dyeing test was performed with complex of curcumin, signified its solubility

This study provides useful approach for obtaining curcumin products with maximum aqueous solubility

GRAPHICAL ABSTRACT
Antioxidant and Anti-inflammatory Activities of Different Solvent Extracts from Ipomoea pes-caprae (L.) R. Br. in Lipopolysaccharide Stimulated RAW 264.7 Macrophages
Authors: Saengkhae Chantarawan , Uawongyart Napaporn , Osiri Sunantha , Srisook Klaokwan , Tangwattanachuleeporn Marut
Published: December 2021

The oxidative stress and inflammatory environment trigger an unhealthy circle, which can lead to various inflammatory diseases. Ipomoea pes-caprae, a traditional medicine mangrove plant, posed many pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. However, the possible mechanisms involved in Ipomoea pes-caprae are still unclear. This study aimed to investigate the antioxidant and anti-inflammatory effects of different solvent extracts from Ipomoea pes-caprae on lipopolysaccharide (LPS) stimulated macrophages. Three different solvent gradients were prepared orderly from non-polar to polar: hexane (Hex), supercritical fluid extraction using carbon dioxide plus EtOH as co-solvent (SCO2) and ethanol (EtOH). All 3 extracts were screened for the cytotoxicity on RAW264.7 cells by MTT assay. The non-toxic doses were investigated for reactive oxygen species (ROS) scavenging by DPPH and DCFH-DA assays and evaluated their anti-inflammatory activities via inhibition against LPS-induced nitric oxide (NO), prostaglandin E2 (PGE2), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression. All 3 extracts (25 - 50 μg/mL) exhibited DPPH scavenging and reduced intracellular ROS level in the order of SCO2 > EtOH > Hex. Further, these extracts suppressed NO and PGE2 production by regulating iNOS and COX-2 mRNA expression in the order of SCO2 > Hex > EtOH. Additionally, their inhibitory effects were in a similar pattern as the standard drugs L-NAME and celecoxib. These findings support the traditional use of Ipomoea pes-caprae in treating inflammatory diseases due to its attenuation of inflammation in activated macrophage. Also, a wide range of secondary metabolites in unique ecology may be useful as one of the alternative therapies for inflammatory diseases.

HIGHLIGHTS

Ipomoea pes-caprae employ a sort of secondary metabolites under stressful high salt conditions with benefit for new drug discoveries

SCO2 extract exhibited the strongest activities in the LPS-induced ROS and PGE2 production

These bioactive compounds contained in Ipomoea pes-caprae confirm the traditional use against jellyﬁsh stings and may targeting inflammatory pathways

GRAPHICAL ABSTRACT
Evaluation of Adaptive Interaction Systems for Virtual Museum Development
Authors: Khundam Chaowanan , Nöel Frédéric
Published: December 2021

Virtual Museum (VM) is an application of Virtual Reality (VR) technology generating realistic visualization and sensation to convince museum visitors to interact with digital content. There are many immersive VR devices that support interactive VM applications. We investigate appropriate devices for interaction within VM. We proposed a Storytelling platform to achieve device organization without modification, the story and interaction were self-adapted to the selected device. Three types of interactive content were designed on our Storytelling platform to be applied on different interaction systems: a 2D standard display, a 3D stereoscopic display and a full immersive CAVE. The results showed different performances of each system supporting VM developers to select an appropriate interaction system. The evaluation contributes to the design of content and interaction of VM development with more efficiency based on user requirements.

HIGHLIGHTS

Three types of interactive content were designed on our Storytelling platform to be applied on different interaction systems: A 2D standard display, a 3D stereoscopic display, and a full immersive CAVE

The 2D Powerwall system with a wide range of views provides immersion. However, with two-dimensional displays, users lack depth perception

Users spent more time in selection and manipulation in the 3D stereoscopic system because depth perception is added

The CAVE system has user attraction or holding power, users spent more interacting time

GRAPHICAL ABSTRACT
Reproductive Characteristics of the Selected Cocoa (Theobroma cacao L.) Clones after Regenerated from the Somatic Embryogenesis Culture
Authors: Entuni Gibson , Nori Hollena , Edward Rebicca , Jaafar Ahmad Kamil bin Mohammad
Published: December 2021

This study was conducted to evaluate the reproductive characteristics of 4 elite cocoa clones (MCBC1, PBC230, KKM22 and KKM4) propagated via somatic embryogenesis culture. From the findings, all clones have similar reproductive characteristics with clones from conventional grafted. However, only KKM4 clone from immature zygotic embryo culture produced the shortest staminode to style distance of 1.83 mm. This consequently influenced flower stability by reducing the efficiency of pollination by insects. It was found that this clone also has the highest number of flowers drop after anthesis (5 flowers) and lowest production of cherelle (5 cherelles). Further observation revealed that floral development from first bud visible (BBCH51) to flower anthesis (BBCH68) of all clones took around 31 days. These cocoa flowers which remained receptive soon after anthesis at 10 am (day-31) until the next day (day-32) suggesting 2 days’ period of receptivity.

HIGHLIGHTS

It is crucial to assess the presence of off-type characteristics in the reproductive organ structure such as the distance between staminode to style, period of reproductive cycle and stigmatic receptivity of cocoa clones regenerated from somatic embryogenesis

The converging and parallel type of staminode to style distances are the ideal flower spatial arrangements for the optimal pollination in cocoa plant compared to splay type

Only KKM4 clone propagated from immature zygotic embryo culture showed variation in the distance between staminode to style distance and this caused pollination failure by insect which then consequently caused minimum cherelle production

All regenerated cocoa clones observed with typical period of the reproductive cycle and stigmatic receptivity

GRAPHICAL ABSTRACT
3D Structural Model and Visualization of Blood Vessels Based on L-System
Authors: Ritraksa Siriprapa , Mekchay Khamron
Published: December 2021

The insight in structures of the blood vessels is a basis for study of blood flows to help understanding the abnormalities of blood vessels that can cause vascular diseases. Basic concept used for constructing structures of blood vessels in organs is arterial branching, which is usually characterized by fractal similarity in the bifurcation pattern. In this work, the concept of Lindenmayer system (L-system) is modified for three-dimensional (3D) tree-like structures to model structures of blood vessels in organs, and then, applied to construct and visualize structural blood vessels via our software created based on openGL and Lazarus program. The structure of blood vessels is constructed based on the physiological law of arterial branching proposed Murray (Murray’s law) under additional assumptions and constraints such as the spreading of blood vessels to cover all directions, the angle condition and the non-overlapping vessels condition. The concept is applied to simulate structures of blood vessels in 3 study cases, including symmetric arterial branching, non-symmetric arterial branching and structure of blood vessel on different domains. The results of structures of blood vessels generated from all cases are measured based on the number of segments, the total blood volume and the fractal dimension. The results of modeling and simulation in this work are illustrated by comparing with other results appeared literature. Moreover, the constructed structures of the blood vessels based on this 3D L-system could be useful for future research such as blood flow, pressure and other properties involving in structures of blood vessels in different organs of human and animals.

HIGHLIGHTS

A new 3D L-system is developed based on directional vectors for construction of 3D tree-like structures such as structures of blood vessels

The model of structures of blood vessels is constructed based on the physiological laws of arterial branching (Murray’s law) with additional assumptions on the spreading of blood vessels, the angle condition, and the non-overlapping of blood vessels

Algorithm and software are developed based on L-system to simulate and visualize 3D structures of blood vessels

GRAPHICAL ABSTRACT
Single Droplet Combustion Characteristics of Petroleum Diesel- Philippine Tung Biodiesel Blends
Authors: Hamidi Nurkholis , Nugroho Joko
Published: December 2021

The purpose of the present study is to investigate the effects of fuel blending of petroleum diesel and biodiesel made from Philippine Tung on the combustion characteristics of fuel droplets. In this study, petroleum diesel was mixed with biodiesel at volume percentages of 0 to 100 % to produce 5 fuel blends. The ratios of fuel blends (petroleum volume/biodiesel volume) were 100:0 (P100), 75:25 (BP25), 50:50 (BP50), 25:75 (BP75) and 0:100 (B100). Single droplet combustion experiments were prepared to understand the combustion characteristics at 3 levels of ambient pressure (100, 200 and 300 kPa). Observations were carried out on the ignition delay time, the burning rate constant, droplet temperature, and the flame visualization. The results showed some effects of the adding of biodiesel in petroleum diesel and the chamber pressure on droplet combustion characteristics.  The adding of biodiesel into petroleum diesel resulted in a shorter ignition delay time and higher burning rate constants. But, the lower heating value of biodiesel caused the lower flame temperature. The possibility of micro-explosion also increased due to the mixing of fuel. On the other hand, increasing the chamber pressure also resulted in shorter ignition delay, higher burning rate, and higher combustion temperature. The higher ambient pressure also compressed the flame dimension and enhanced the onset of micro-explosion.

HIGHLIGHTS

The adding of biodiesel into petroleum diesel with different physical and chemical properties impacts the droplet combustion behavior, especially on the characteristics of burning rate, ignition delay time, flame temperature, and micro explosion

The high content of unsaturated fatty acids and oxygen in Philippine Tung biodiesel improves the ignition delay time and burning rate constants of the blended fuel, but, the lower heating value causes the lower flame temperature

The multi-components of fatty acids with different boiling points in Philippine Tung oil promote the micro-explosion in the combustion of the mixtures of biodiesel and petroleum diesel fuel

GRAPHICAL ABSTRACT
The Potential of Biogas Production with Co-Digestion between Food Waste and Cow Dung
Authors: Pakvilai Nisa
Published: December 2021

The objective of this research was to analyze the potential of biogas production with co-digestion between food waste and cow dung. The experiment research was batched with small scale and scale up with semi-continuous, temperature was operated within 35 - 37 °C. The suitable condition for biogas production between food waste and cow dung was presented with 75:25 (T1). 55 mL of the biogas potential was obtained which is considered as small scale. Thus, the scale up was presented in 75:25 (T1) ratio. In term of scale up the biogas obtained from the production is 650 ml which is higher than small scale. The scale up reactor of biogas production was 100 liters. Chemical oxygen demand (COD) was reduced from 30,000 to 5,000 - 7,000 mL L-1. The efficiency of COD was obtained 76.67 - 83.3 %, respectively. In term of total solid, it was decreased from 19,000 to 16,500 mL L-1. Initial VFA was presented 4,000 mL L-1, and final was presented 3,800 mL L-1, respectively. However, the biogas production from food waste and cow dung can enhance the performance of municipal solid waste and alternative energy production. Finally, the finding of co-digestion in biogas production system suggested utilization in household and communities.

HIGHLIGHTS

Food waste is the major waste in household, and it has high potential for energy production

Co-digestion in biogas production system that suggested utilization in household and communities

The biogas production from food waste and cow dung can enhance the performance of municipal solid waste and alternative energy production

GRAPHICAL ABSTRACT
Comparing Micro-Ultrasound to mpMRI in Detecting Clinically Significant Prostate Cancer
Authors: Tan Guan Hee , Wodlinger Brian , Pavlovich Christian , Klotz Laurence
Published: December 2021

Objectives To compare the performance of micro-ultrasound (mUS) with multi-parametric magnetic resonance imaging (mpMRI) in detecting clinically significant prostate cancer. Materials and Methods Retrospective data from consecutive patients with any indication for prostate biopsy in 2 academic institutions were included. The operator, blinded to mpMRI, would first scan the prostate and annotate any mUS lesions. All mUS lesions were biopsied. Any mpMRI lesions that did not correspond to mUS lesion upon unblinding were additionally biopsied. Grade group (GG) ≥ 2 was considered clinically significant cancer. The Jeffreys interval method was used to compare performance of mUS with mpMRI with the non-inferiority limit set at −5%. Results Imaging and biopsy were performed in 82 patients with 153 lesions. mUS had similar sensitivity to mpMRI (per-lesion analysis: 78.4% versus 72.5%), but lower specificity, positive predictive value, negative predictive value, and area under the curve. Micro-ultrasound found GG ≥ 2 in 13% of cases missed by mpMRI, while mpMRI found GG ≥ 2 in 11% of cases missed by mUS. The difference 0.020 (95% CI −0.070 to 0.110) was not statistically significant (P = 0.33). Conclusion The sensitivity of mUS in detecting GG ≥ 2 disease was similar to that of mpMRI, but the specificity was lower. Further evaluation with a larger sample size and experienced operators is warranted.
Verteporfin: A Novel Antiproliferative Agent for Urinary Tract Fibrosis?
Authors: Singh Jas
Published: December 2021

No abbstract.
Urology Residency Training During the Pandemic: A Review of the Current Literature
Authors: Glykas Ioannis , Stamatakos Panagiotis Velissarios , Fragkoulis Charalampos , Moussa Mohamad , Papatsoris Athanasios , Ntoumas Georgios , Dellis Athanasios
Published: December 2021

Background Since COVID–19 was declared a pandemic on March 11, 2020, health care systems worldwide have been under significant strain. Although urology is not on the frontline of care for patients with COVID-19, every practicing urologist has been affected by the global outbreak. The objective of this review is to evaluate the impact of COVID–19 pandemic on urology residency training programs. Methods We reviewed the current evidence on urology residency training during the COVID-19 pandemic. Relevant databases (MEDLINE, Scopus, Cochrane Library) were searched for articles published to June 2021 that included residents’ or directors’ opinions on their residency training programs during the COVID-19 crisis. Results The literature search identified 72 articles. Fifteen studies including more than 2500 residents were eligible for inclusion in the analysis. During the pandemic, learning activities carried out by urology residents have been extensively affected. Worldwide, operation volume has decreased, especially for procedures in which residents were directly involved. Similarly, there has been a decline in most academic activities, and many studies have reported the negative impact on residents’ mental well-being and lifestyle. On the other hand, the lockdown provided an opportunity to review the current training system and to increase the implementation of tools such as telemedicine and smart-learning surgical skill training programs. Conclusion The COVID-19 pandemic has resulted in significant changes in urology residency programs worldwide, which have had a negative impact on surgical training and academic activities. Residents’ well-being and mental health have also been put at risk. However, this unprecedented situation has also generated new online learning modalities and technological innovations in the field of training in urology.
One-Year Outcomes of the ROBUST II Study Evaluating the Use of a Drug-Coated Balloon for Treatment of Urethral Stricture
Authors: DeLong Jessica , Ehlert Michael J. , Erickson Bradley A. , Robertson Kaiser J. , Virasoro Ramón , Elliott Sean P.
Published: December 2021

Objective To report 1-year results of the ROBUST II study investigating the safety and efficacy of a paclitaxel-coated balloon for the treatment of recurrent urethral strictures. Methods Subjects were adult men with a single anterior urethral stricture ≤ 3 cm in length and at least 2 prior stricture treatments. After treatment with the Optilume urethral drug-coated balloon (DCB), subjects were followed through 1 year. The primary safety endpoint was the rate of treatment-related serious complications at 90 days post-procedure. Efficacy outcomes included symptomatic assessments, erectile function measured using the International Index of Erectile Function (IIEF), Qmax, and anatomic success. Results Sixteen men with an average of 4.1 prior dilations were treated with the DCB. Anatomic success was achieved at 6 months in 73%. Average IPSS improved from 18.4 to 6.0 at 1 year (P < 0.001). Qmax improved from 6.9 mL/sec to 20.8 mL/sec (P < 0.001). There was no change in IIEF. Four subjects received additional treatment within 1 year. There were no treatment-related serious complications. Conclusions Short-term follow-up of men with urethral stricture treated with the Optilume DCB showed durable anatomic results at 6 months and sustained symptomatic improvement through 1 year. Treatment with the device was safe.
A Rare Case of Hypersensitivity Reaction Associated With Sacral Neuromodulation Hardware
Authors: Vignaroli Kendall A. , Popat Shreeya , Kobashi Kathleen C.
Published: December 2021

No abstract.
Urological Involvement in the Multidisciplinary Management of Placenta Accreta Spectrum in a Centralised, High-Volume Centre: A Retrospective Analysis
Authors: Kelly Brian D. , Moorhead Rebecca , Wetherell David , Gilchrist Tracey , Furrer Marcalain , Perera Marlon , Norris Briony , Wrede David , Umstad Mark , Kearsley Jamie , Al-Shammaa Faris
Published: December 2021

Objectives Placenta accreta spectrum (PAS) significantly increases the complexity of childbirth and frequently involves urologic organs. Multidisciplinary team (MDT) care is paramount to ensure optimal outcomes. We aimed to evaluate urologic interventions in patients with PAS at a centralised, tertiary referral centre. Methods An analysis of a prospectively collected data set, consisting of all women presenting with PAS at our institution between November 2013 and June 2019. Patients who required urological intervention were identified, and perioperative details were retrieved. Results Forty-two cases of PAS were identified. The mean maternal age was 35 years, and mean gestational age at delivery was 34 weeks. Thirty-seven cases were managed electively, with 5 cases managed conservatively (no hysterectomy) and 5 requiring emergency management. Fifteen patients (36%) had suspected bladder invasion on MRI. A total of 36 patients (86%) had ureteric catheters inserted, 14 (33%) required bladder repair, and 2 had ureteric injuries (5%). Conclusions PAS frequently requires urological intervention to prevent and repair injury to the urinary bladder and ureter. PAS is a rare condition that is best managed in an MDT setting in a centralised, tertiary, high-volume centre with access to a variety of medical and surgical sub-specialities.
Our Billion-Dollar Donation to the Publishing Industry
Authors: Black Peter C.
Published: December 2021

No abstract.
The Efficacy and Safety of a Conservative Management Approach to Radiation-Induced Male Urethral Strictures in Elderly Patients With Comorbidities
Authors: Rozanski Alexander T. , Moynihan Matthew J. , Zhang Lawrence T. , Muise Alexandra C. , Holst Daniel D. , Copacino Steven A. , Zinman Leonard N. , Buckley Jill C. , Vanni Alex J.
Published: December 2021

Objectives To assess the outcomes of a conservative management approach to radiation-induced urethral stricture disease (R-USD) in an elderly population with comorbidities. Methods Patients with R-USD managed with endoscopic procedures and/or clean intermittent catheterization (CIC) between 2007 and 2019 were included. Patients were excluded if they had an obliterative stricture, prior urethral reconstruction/urinary diversion surgery, or < 3 months follow-up. Primary outcome measures were urinary tract infection (UTI), acute urinary retention (AUR), serum creatinine, uroflowmetry/post-void residual, and urinary incontinence (UI). Failure was defined as progression to reconstructive surgery or permanent indwelling catheterization. Results Ninety-one men were analyzed with a median follow-up of 15.0 months (IQR 8.9 to 37.9). Median age was 75.4 years (IQR 70.0 to 80.0), body mass index was 26.5 kg/m2 (IQR 24.8 to 30.3), and Charlson comorbidity index was 6 (IQR 5 to 8). Median stricture length was 2.0 cm (IQR 2.0 to 3.0). Stricture location was bulbar (12%), bulbomembranous (75%), and prostatic (13%). A total of 90% underwent dilation, and 44% underwent direct visual internal urethrotomy (DVIU). For those that underwent these procedures, median number of dilations and DVIUs per patient was 2 (IQR 1 to 5) and 1 (IQR 1 to 3), respectively. Forty percent used CIC. Thirty-four percent developed a UTI, and 15% had an AUR episode requiring urgent treatment. Creatinine values, uroflowmetry measurements, and UI rates remained stable. Eighty percent avoided reconstructive surgery or indwelling catheterization. Conclusion Most elderly patients with comorbidities with R-USD appear to be effectively managed in the short-term with conservative strategies. Close observation is warranted because of the risk of UTIs and AUR. The potential long-term consequences of repetitive conservative interventions must be considered.
Carpooling in Smart City using SIoT: Vision, Challenges and Future Scope
Authors: Ray Paulami Basu
Published: December 2021

Carpooling or Ridesharing is the need of the hour owing to increase in transportation cost, increased traffic congestion due to huge number of vehicles on road etc. Several attempts at proposing efficient ridesharing methods are being made by the researchers and Government authorities of several nations. Each method has its own advantage as well as disadvantage. How to group people who would car-pool is a problem of concern. Their source and destination would play a pivotal role. Knowing their preferred route in advance can be helpful. Now, if we consider the Carpooling problem as a part of a Smart City where any physical object is connected to the network through the Internet of Things (IoT) the problem can be dealt with a different perspective. A lot of work is already there where connected vehicles can communicate with each other through Wireless Sensor Network(WSN) or IOT(Internet of Things). Social Internet of Things (SIOT) deals with the concept that in addition to being smart, things are also social. It is a comparatively novel concept; some interesting works are being done regarding this field. Our article’s primary focus is to provide a review of the recent work regarding ridesharing and SIOT which will help us analyse these concepts and pave a path for future developments in this field.
Coded Websites vs Wordpress Websites
Authors: S Geetha. , Shasvat Shasvat , Shah Harsh
Published: December 2021

This document gives multiple instructions related to web developers using older as well as newer technology. Websites are being created using newer technologies like wordpress whereas on the other hand many people prefer making websites using the traditional way. This document will clear the doubt whether an individual should use wordpress websites or coded websites according to the users convenience. The Responsiveness of the websites, the use of CMS nowadays, more and more up gradation of technologies with SEO, themes, templates, etc. make things like web development much much easier. The aesthetics, the culture, the expressions, the features all together add up in order make
the designing and development a lot more efficient and effective. Digital Marketing has a tremendous growth over the last two years and yet shows no signs of stopping, is closely related with the web development environment. Nowadays all businesses are going online due to which the impact of web development has become such that it has become an integral part of any online business.
Şiî Düşüncenin Hâkimiyetindeki İran’da Tefsîr Eğitimi: Tahran Üniversitesi İlahiyat Fakültesi Tefsîr Bölümü Örneği
Authors: ERGİN Mehmet Beşir , ASLAN Harun
Published: December 2021

Günümüz İslâm ülkelerinde Kur’ân’ı anlama ve yorumlama gayretiyle gerçekleştirilen tefsîr eğitimi gayrî resmî olarak farklı kurumlar bünyesinde gerçekleştiği gibi resmî olarak yüksek öğretim kurumlarının uhdesinde de icra edilmektedir. Üniversitelerde bu eğitimin verildiği yerler ise İlahiyat fakülteleridir. İlahiyat fakülteleri fıkıh, hadîs, kelâm, tasavvuf ve benzeri birçok disiplini bünyesinde barındırmaktadır. Şiî düşüncenin merkezi olan İran’daki Tahran Üniversitesi İlahiyat Fakültesi de bu kurumlardan biridir. Söz konusu fakültede tefsîr bölümü lisans düzeyinde hadîsle birlikte müstakil olarak eğitim faaliyetlerini yürütmektedir. Bölümde iki alana ait dersler ilk senelerde ortak olarak tedrîs edilirken sonraki yıllarda öğrencinin eğilimine göre birbirinden ayrılmaktadır. Umûmî (Üniversite tarafından Konulan Zorunlu Dersler) ve Pâye (Temel Dersler) dersleri daha çok İslâmî disiplinlerin geneli ile ilgili dersler hakkında iken, uzmanlık ve seçmeli dersler ise alana yönelik olmaktadır. Bu bağlamda tefsîr dersleri uzmanlık/ihtisâs dersleri kategorisinde yoğun bir şekilde işlenmektedir. Bu çalışmada öncelikle Şia mezhebi çatısı altında yönetilen İran’ın köklü ve modern eğitim kurumlardan biri olan Tahran Üniversitesi İlahiyat Fakültesinin genel çerçevesi üzerinde durulmakta; ardından çalışmanın ana nîrengini oluşturan Kur’ân İlimleri bölümündeki ders müfredatı lisans düzeyi ile sınırlandırılarak tasvîrî bir şekilde ele alınmaktadır.
Restoration of Trigeminal Cutaneous Sensation with Cross-Face Sural Nerve Grafts: Case Report and Literature Review
Authors: Vũ Trung Trực ,   Bùi Mai Anh
Published: December 2021

Abstract

Complete anesthesia leaves patients susceptible to occult injury, and facial sensation is an important component of interaction and activities of daily living. Although treating facial palsy is considered debilitating for patients, trigeminal nerve palsy and sensory deficits of the face are overlooked components of disability. The authors reported the first case in Vietnam: 38 year-old man who lost the sensation on his right face follow by V cranial nerve tumor resection one year before. The sensation of the trigeminal cutaneous nerve was restored with cross-face sural nerve graft from contralateral side in 2018. The patient demonstrated improved sensation in the reconstructed dermatomes without donor-site aNBormalities at the time of 18 months post operation.

Keywords: Facial palsy, facial sensation, trigeminal nerve tumor, cross-face nerve graft.
Outcomes of arthroscopy in recurrent shoulder instability at
Viet Duc University Hospital
Authors: Cao Đình Bằng ,   Hoang Minh Thang, Luu Danh Huy, Phung Ngoc Hoa, Nguyen Manh Khanh, Ngo Van Toan
Published: December 2021

Abstract
Introduction: This study aims to assess the results of patients with recurrent
shoulder dislocation treated with arthroscopic Bankart repair.
Patients and Method: 31 patients (26 males and 5 females, with an average
age of 28.7) were treated with arthroscopic Bankart repair from 2017 to
2018. Those with multidirectional instability, posterior shoulder instability
and more-than-25% Hill-Sachs defects, along with those who had prior
shoulder surgeries were excluded. Average follow-up time after surgery
is 15.13 months. Frequency of pre-operative dislocation, post-operative
dislocation, functional status and daily activity performance were evaluated.
The results were assessed using CONSTANT score.
Results: One patient had post-operative dislocation (3.23%). One patient
had post-operative joint adhesion (3.23%). Assessment using CONSTANT
score showed an excellent result in 67.4%, good in 12.9%, moderate in
12.9% and average in 6.46%. There was no case with poor result. One
patient had post-operative dislocation due to a sport injury.
Conclusions: Arthroscopic repair is a modern technology, and is being used
widely in diagnosing and treating shoulder lesions. This study shows that
arthroscopic repair for recurrent shoulder dislocation may bring good result
for patients.
Keywords: Shoulder instability, arthroscopy, Bankart.
Early outcomes of robotic distal gastrectomy with D2 lymphadenectomy for gastric cancer at Binh Dan Hospital
Authors: Trần Vĩnh Hưng ,   Hoàng Vĩnh Chúc, Nguyễn Phúc Minh, Vũ Khương An
Published: December 2021

Abstract
Introduction: Gastric cancer is one of the five most common malignancies in Vietnam and worldwide. Recently, robotic gastrectomy with lymphadenectomy has become a new trend in the treatment of gastric cancer. In Vietnam, we conducted this study to assess the safety and feasibility of this procedure.
Patients and methods: Descriptive study with a case series enrolled 13 patients with lower third gastric cancer underwent gastrectomy with lymphadenectomy by Si-generation da Vinci robot at Binh Dan Hospital from 01/01/2017 to 31/07/2019.
Results: Male/female ratio was 2.25:1. The median age was 56.92 ± 8.66 years old. The pre-operative staging (cTNM) was mostly stage III. Robot docking time was 15 ± 7.36 minutes. The total operating time was 225.38 ± 36.43 minutes. The average blood loss during surgery was 66.15 ± 23.64 ml. There were no intraoperative accident as well as early postoperative complication. The postoperative hospital stay was 7.62 ± 0.87 days. The total number of metastatic lymph nodes was 1.62 ± 1.61 nodes. The postoperative staging was IIIA (53.85%), IIB (23.08%), IIA (15.38%) and IB (7.69%) respectively.
Conclusions: Robotic gastrectomy is a safe procedure with promising indexes during and after surgery.
Key word: Gastric cancer, robotic surgery.

Tóm tắt
Đặt vấn đề: Ung thư dạ dày (UTDD) là một trong năm loại ung thư phổ biến nhất tại Việt Nam và trên thế giới. Phẫu thuật robot cắt dạ dày và nạo hạch trở thành xu hướng điều trị mới trong UTDD. Tại Việt Nam, chúng tôi tiến hành nghiên cứu sau để tìm hiểu tính an toàn và khả thi của phương pháp phẫu thuật này.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hàng loạt ca: 13 trường hợp ung thư dạ dày 1/3 dưới được phẫu thuật bằng robot da Vinci thế hệ Si tại bệnh viện Bình Dân từ 01/01/2017 đến 31/7/2019.
Kết quả: Tỉ lệ nam : nữ là 2,25 : 1. Độ tuổi trung bình là 56,92 ± 8,66 tuổi. Giai đoạn bệnh trước mổ (cTNM) đa số là giai đoạn III. Thời gian docking robot là 15 ± 7,36 phút. Thời gian mổ toàn bộ là 225,38 ± 36,43 phút. Lượng máu mất trong mổ là 66,15 ± 23,64 ml. Tỉ lệ tai biến và biến chứng sớm là 0%. Thời gian nằm viện sau mổ là 7,62 ngày ± 0,87 ngày. Tổng số hạch di căn là 1,62 ± 1,61 hạch. Giai đoạn bệnh sau mổ bao gồm IIIA (53,85%), IIB (23,08%), IIA (15,38%), IB (7,69%).
Kết luận: Phẫu thuật bằng robot cắt dạ dày là một phương pháp phẫu thuật an toàn với các chỉ số trong mổ và sau mổ đầy khả quan.
Từ khóa: Phẫu thuật robot, ung thư dạ dày.