bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence and Determinants of Bad Sleep Perception among Italian Children and Adolescents
Authors: Malloggi Serena , Conte Francesca , Gronchi Giorgio , Ficca Gianluca , Giganti Fiorenza
Published: December 2020

Although sleep problems at young ages are well investigated, the prevalence of bad sleepers and the determinants of sleep quality perception remain unexplored in these populations. For this purpose, we addressed these issues in a sample of children (n = 307), preadolescents (n = 717), and adolescents (n = 406) who completed the School Sleep Habits Survey, addressing sleep quality perception, sleep habits, sleep features, daytime behavior and sleep disturbances, circadian preference, and dreaming. The sample was split in “good sleepers” and “bad sleepers”, based on the answer to the question item assessing overall subjective sleep quality. Being a bad sleeper was reported by 11.7% of the sample, with significant between-groups differences (children: 8.3%; preadolescents: 11.3%; adolescents: 15.3%; p = 0.01). At all ages, relative to good sleepers, bad sleepers showed higher eveningness, sleepiness, and depression, longer sleep latency, more frequent insufficient sleep, nocturnal awakenings, sleep–wake behavioral problems, and unpleasant dreams (all p’s ≤ 0.01). Sleep quality perception was predicted: in children, by depressed mood, eveningness, and unpleasant dreams (all p’s ≤ 0.01); in preadolescents, by sleep latency, awakening frequency, depressed mood, sufficiency of sleep, and unpleasant dreams (all p’s < 0.01); in adolescents, by awakening frequency, depressed mood, and sufficiency of sleep (all p’s < 0.001). In children, bad subjective sleep quality appears to be mainly determined by daytime psychological features, for example, depressed mood, whereas at later ages, sleep characteristics, such as frequent awakenings, add to the former determinants. This could depend on (a) the appearance, with increasing age, of objective sleep modifications and (b) a greater attention paid by adolescents to their sleep characteristics.
Preconception Care Program for Women with Inflammatory Bowel Disease Using Intervention Mapping: A Protocol for Program Development
Authors: Lee Young Jin , Kim Yeon Hee , Kim Hae Won
Published: December 2020

The prevalence of inflammatory bowel disease in Korea is rapidly increasing. Women with inflammatory bowel disease have a higher risk of adverse birth outcomes than healthy women, and the magnitude of this risk is related to the severity of the disease at the time of pregnancy. For a woman with inflammatory bowel disease to have a healthy pregnancy, interventions are needed to manage the disease before pregnancy—implying a need for pregnancy planning. In this study, the intervention mapping protocol was used to develop a program for this purpose. This protocol contains the following stages: needs assessment, setting of program outcomes and performance objectives, selection of methods and strategies based on theory, and development of the program and its materials. Through individual in-depth interviews and a literature review, individual and environmental determinants were assessed and six change objectives of the program were set. The methods and practical strategies were developed based on the information-motivation-behavioral skills model, self-efficacy theory, and social support theory. The final program, consisting of four sessions and the corresponding materials, was completed by making revisions based on a content validity assessment by experts and a pilot test. Follow-up studies on the implementation of this program will be conducted in the future.
The Sensitivity of a Specific Denitrification Rate under the Dissolved Oxygen Pressure
Authors: Raboni Massimo , Viotti Paolo , Rada Elena Cristina , Conti Fabio , Boni Maria Rosaria
Published: December 2020

The biological denitrification process is extensively discussed in scientific literature. The process requires anoxic conditions, but the influence of residual dissolved oxygen (DO) on the efficiency is not yet adequately documented. The present research aims to fill this gap by highlighting the effects of DO on the specific denitrification rate (SDNR) and consequently on the efficiency of the process. SDNR at a temperature of 20 °C (SDNR20°C) is the parameter normally used for the sizing of the denitrification reactor in biological-activated sludge processes. A sensitivity analysis of SNDR20°C to DO variations is developed. For this purpose, two of the main empirical models illustrated in the scientific literature are taken into consideration, with the addition of a deterministic third model proposed by the authors and validated by recent experimentations on several full-scale plants. In the first two models, SDNR20°C is expressed as a function of the only variable food:microrganism ratio in denitrification (F:MDEN), while in the third one, the dependence on DO is made explicit. The sensitivity analysis highlights all the significant dependence of SDNR20°C on DO characterized by a logarithmic decrease with a very pronounced gradient in correspondence with low DO concentrations. Moreover, the analysis demonstrates the relatively small influence of F:MDEN on the SDNR20°C and on the correlation between SDNR20°C and DO. The results confirm the great importance of minimizing DO and limiting, as much as possible, the transport of oxygen in the denitrification reactor through the incoming flows and mainly the mixed liquor recycle. Solutions to achieve this result in full-scale plants are reported.
Persistence of COVID-19 Symptoms after Recovery in Mexican Population
Authors: Galván-Tejada Carlos E. , Herrera-García Cintya Fabiola , Godina-González Susana , Villagrana-Bañuelos Karen E. , Amaro Juan Daniel De Luna , Herrera-García Karla , Rodríguez-Quiñones Carolina , Zanella-Calzada Laura A. , Ramírez-Barranco Julio , Avila Jocelyn L. Ruiz de , Reyes-Escobedo Fuensanta , Celaya-Padilla José M. , Galván-Tejada Jorge I. , Gamboa-Rosales Hamurabi , Martínez-Acuña Mónica , Cervantes-Villagrana Alberto , Rivas-Santiago Bruno , Gonzalez-Curiel Irma E.
Published: December 2020

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease (COVID-19), a highly contagious infectious disease that has caused many deaths worldwide. Despite global efforts, it continues to cause great losses, and leaving multiple unknowns that we must resolve in order to face the pandemic more effectively. One of the questions that has arisen recently is what happens, after recovering from COVID-19. For this reason, the objective of this study is to identify the risk of presenting persistent symptoms in recovered from COVID-19. This case-control study was conducted in one state of Mexico. Initially the data were obtained from the participants, through a questionnaire about symptoms that they had at the moment of the interview. Initially were captured the collected data, to make a dataset. After the pre-processed using the R project tool to eliminate outliers or missing data. Obtained finally a total of 219 participants, 141 recovered and 78 controls. It was used confidence level of 90% and a margin of error of 7%. From results it was obtained that all symptoms have an associated risk in those recovered. The relative risk of the selected symptoms in the recovered patients goes from 3 to 22 times, being infinite for the case of dyspnea, due to the fact that there is no control that presents this symptom at the moment of the interview, followed by the nausea and the anosmia with a RR of 8.5. Therefore, public health strategies must be rethought, to treat or rehabilitate, avoiding chronic problems in patients recovered from COVID-19.
Occupational Risk for Post-Traumatic Stress Disorder and Trauma-Related Depression: A Systematic Review with Meta-Analysis
Authors: Petereit-Haack Gabriela , Bolm-Audorff Ulrich , Romero Starke Karla , Seidler Andreas
Published: December 2020

There is evidence suggesting that occupational trauma leads to post-traumatic stress disorder (PTSD) and depression. However, there is a lack of high-quality reviews studying this association. We, therefore, conducted a systematic review with a meta-analysis to summarize the evidence of occupational trauma on PTSD and depression. After a database search on studies published between 1994 and 2018, we included 31 studies, of which only four had a low risk of bias. For soldiers exposed to wartime deployment, the pooled relative risk (RR) was 2.18 (95% CI 1.83–2.60) for PTSD and 1.15 (95% CI 1.06–1.25) for depression. For employees exposed to occupational trauma, there also was an increased risk for PTSD (RR = 3.18; 95% CI 1.76–5.76) and for depression (RR = 1.73; 95% CI 1.44–2.08). The overall quality of the evidence according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was moderate; the evidence was high only for the association between workers after exposure to trauma and development of PTSD. The study results indicate an increased risk of PTSD and depression in soldiers after participation in war and in employees after occupational trauma.
Can an Abusive Supervision Be a Predictor of Doocing? Comment on Akram, Z.; Li, Y.; Akram, U. When Employees Are Emotionally Exhausted Due to Abusive Supervision. A Conservation-of-Resources Perspective. Int. J. Environ. Res. Public Health 2019, 16, 3300
Authors: Fantinelli Stefania
Published: December 2020

Thanks to the research work of Akram and colleagues on the consequences of an abusive supervision, it is possible to hypothesize a new point of view of the doocing phenomenon. According to the authors, an abusive supervision can cause, through the interaction of some mediators and moderators, counterproductive work behaviors; this comment proposes that these behaviors can be performed also in an online context. As a consequence, a worker could be fired because of something posted on social media (doocing). Another relevant point of view concerns the great responsibility given to supervisors and management with regard to the care of job environment from an emotional point of view.
Promoting Higher Quality Teacher–Child Relationships: The INSIGHTS Intervention in Rural Schools
Authors: Rudasill Kathleen Moritz , Reichenberg Ray E. , Eum Jungwon , Barrett Jentry Stoneman , Joo Yuenjung , Wilson Emily , Sealy Martinique
Published: December 2020

Children’s relationships with teachers in kindergarten are crucial for academic and social success. Research shows that teacher–child relationships are predicated, in part, on children’s temperament. The “INSIGHTS into Children’s Temperament” intervention was intended to improve children’s and teachers’ understanding of their and others’ temperament, and has been shown to improve children’s social skills and self-regulation in urban, under-resourced schools. The current study is part of a replication of the effects of INSIGHTS with a sample in rural schools. The purpose was to test the effectiveness of INSIGHTS for promoting positive relationships between teachers and children in kindergarten. Two cohorts of kindergarten students (N = 127) and teachers (N = 30) were randomized into INSIGHTS or control conditions by school. Teachers reported on the quality of the teacher–child relationship before and after the INSIGHTS intervention (Time 1 and 2) using the Student–Teacher Relationship Scale: Short Form and provided a rating of children’s temperament with the Teacher School-Age Temperament Inventory at Time 1. Data were analyzed with hierarchical linear modeling. Two significant findings emerged. First, INSIGHTS promoted more closeness between teachers and children, regardless of temperament. Second, the INSIGHTS intervention was protective against the development of conflictual teacher–child relationships for children with negative reactivity.
Effects of Hearing Disability on the Employment Status Using WHODAS 2.0 in Taiwan
Authors: Chao Pin-Zhir , Huang Shih-Wei , Escorpizo Reuben , Chi Wen-Chou , Yen Chia-Feng , Liao Hua-Fang , Chen Yi-Wen , Liou Tsan-Hon
Published: December 2020

The aim of this study was to explore the association between employment status and World Health Organization Disability Assessment Schedule, Second Edition (WHODAS 2.0) scores of working-age subjects with hearing impairment. The data of 18,573 working-age subjects (age ≥ 18 and <65 years) with disabling hearing impairment were obtained from the Taiwan Data Bank of Persons with Disability (TDPD) for the period from 11 July 2012 to 31 October 2018. Demographic data and WHODAS 2.0 scores for each domain were analyzed to identify their relationship with employment status. Unemployed subjects with disabling hearing impairment had higher WHODAS 2.0 scores in all domains compared with the employed subjects. Binary logistic regression revealed that older age, female sex, lower educational level, institutional residence, rural residence, lower family income, and moderate to severe impairment were more strongly associated with unemployment status. The data in this large population-based study offer comprehensive information on important factors associated with the employment status of people with disabling hearing impairment. Early identification of risks of unemployment of patients with hearing impairment can raise awareness for aggressive community and government campaigns regarding public health to improve the self-confidence, social participation, and related psycho-social wellbeing of people.
Longitudinal Prospective Association between Hedonic Hunger and Unhealthy Food and Drink Intake in Adolescents
Authors: Mason Tyler B. , Smith Kathryn E. , Lavender Jason M. , Leventhal Adam M.
Published: December 2020

Hedonic hunger (i.e., extreme responsiveness to food) has been associated with obesity and poor diet, but findings in the existing literature have primarily been cross-sectional. The current study examined hedonic hunger as a prospective predictor of the longitudinal trajectory of unhealthy food and drink intake across adolescence. Ninth grade students from Los Angeles area high schools (analyzed sample N = 3268) completed paper-and-pencil surveys across four annual waves; hedonic hunger was assessed at Wave 1, and unhealthy food and drink intake was assessed at Waves 1–4. Multilevel models showed a significant main effect of hedonic hunger and interactions between hedonic hunger and the linear and quadratic components of time. The association between hedonic hunger and unhealthy food and drink intake was strongest at Wave 1 and weakened over time, yet those with higher hedonic hunger reported greater unhealthy food and drink intake across the four years. Efforts to prevent and intervene upon hedonic hunger and its association with unhealthy food and drink intake during childhood and adolescence are warranted.
Vaccination Status and Attitude among Measles Cluster Cases in Austria, 2019
Authors: Henszel Lukasz , Kanitz Elisabeth E. , Grisold Andrea , Holzmann Heidemarie , Aberle Stephan W. , Schmid Daniela
Published: December 2020

On 21 January 2019, public health authorities of two neighboring Austrian provinces reported an increase in measles cases. We investigated this occurrence to identify clusters of epidemiologically linked cases and the associated vaccination status in order to generate hypotheses on those factors explaining the size of the measles clusters. Probable cases were residents of the provinces of Styria or Salzburg with clinical presentation of measles after 1 January 2019 who were linked to a confirmed case using RNA virus detection. We collected data on age, rash onset, certificate-based vaccination status and reasons for being unvaccinated. Contact history was used to identify chains of transmission. By 11 March, we identified 47 cases, with 40 (85.1%) in unvaccinated patients. A cluster of 35 cases with a median age of seven years (IQR: 1–11) occurred between 9 January and 20 February in the province of Styria due to one transmission chain with four case generations. Of 31 vaccine-eligible cases, 25 (80.6%) were unvaccinated, of which 13 refused vaccination. Between 10 January and 1 March, we identified 12 cases as part of five unlinked clusters in the province of Salzburg. Each of these five clusters consisted of two generations: the primary case and the successive cases (median age: 22 years, IQR: 11–35). Eleven of 12 cases occurred in unvaccinated patients, with none of the 11 having a vaccination-refusing attitude. An extended measles cluster in a vaccination-refusing community, compared to five short-lived clusters concurrently occurring in the neighboring province, illustrates how vaccine refusal may hamper control of transmission.
Cholera Risk: A Machine Learning Approach Applied to Essential Climate Variables
Authors: Campbell Amy Marie , Racault Marie-Fanny , Goult Stephen , Laurenson Angus
Published: December 2020

Oceanic and coastal ecosystems have undergone complex environmental changes in recent years, amid a context of climate change. These changes are also reflected in the dynamics of water-borne diseases as some of the causative agents of these illnesses are ubiquitous in the aquatic environment and their survival rates are impacted by changes in climatic conditions. Previous studies have established strong relationships between essential climate variables and the coastal distribution and seasonal dynamics of the bacteria Vibrio cholerae, pathogenic types of which are responsible for human cholera disease. In this study we provide a novel exploration of the potential of a machine learning approach to forecast environmental cholera risk in coastal India, home to more than 200 million inhabitants, utilising atmospheric, terrestrial and oceanic satellite-derived essential climate variables. A Random Forest classifier model is developed, trained and tested on a cholera outbreak dataset over the period 2010–2018 for districts along coastal India. The random forest classifier model has an Accuracy of 0.99, an F1 Score of 0.942 and a Sensitivity score of 0.895, meaning that 89.5% of outbreaks are correctly identified. Spatio-temporal patterns emerged in terms of the model’s performance based on seasons and coastal locations. Further analysis of the specific contribution of each Essential Climate Variable to the model outputs shows that chlorophyll-a concentration, sea surface salinity and land surface temperature are the strongest predictors of the cholera outbreaks in the dataset used. The study reveals promising potential of the use of random forest classifiers and remotely-sensed essential climate variables for the development of environmental cholera-risk applications. Further exploration of the present random forest model and associated essential climate variables is encouraged on cholera surveillance datasets in other coastal areas affected by the disease to determine the model’s transferability potential and applicative value for cholera forecasting systems.
Intermittent Fasting, Dietary Modifications, and Exercise for the Control of Gestational Diabetes and Maternal Mood Dysregulation: A Review and a Case Report
Authors: Ali Amira Mohammed , Kunugi Hiroshi
Published: December 2020

Gestational diabetes mellitus (GDM) is a common pregnancy-related condition afflicting 5–36% of pregnancies. It is associated with many morbid maternal and fetal outcomes. Mood dysregulations (MDs, e.g., depression, distress, and anxiety) are common among women with GDM, and they exacerbate its prognosis and hinder its treatment. Hence, in addition to early detection and proper management of GDM, treating the associated MDs is crucial. Maternal hyperglycemia and MDs result from a complex network of genetic, behavioral, and environmental factors. This review briefly explores mechanisms that underlie GDM and prenatal MDs. It also describes the effect of exercise, dietary modification, and intermittent fasting (IF) on metabolic and affective dysfunctions exemplified by a case report. In this patient, interventions such as IF considerably reduced maternal body weight, plasma glucose, and psychological distress without any adverse effects. Thus, IF is one measure that can control GDM and maternal MDs; however, more investigations are warranted.
A Review of the Current Status of Gestational Diabetes Mellitus in Australia—The Clinical Impact of Changing Population Demographics and Diagnostic Criteria on Prevalence
Authors: Laurie Josephine G , McIntyre H. David
Published: December 2020

The current status of gestational diabetes mellitus in Australia reveals an almost quadrupling prevalence over the last decade. A narrative review of the current Australian literature reveals unique challenges faced by Australian maternity clinicians when addressing this substantial disease burden in our diverse population. Rising rates of maternal overweight and obesity, increasing maternal age and the diversity of ethnicity are key epidemiological impactors, overlaid by the 2015 changes in screening and diagnostic parameters. Our vast land mass and the remote location of many at risk women requires innovative and novel ideas for pathways to diagnose and effectively manage women with gestational diabetes mellitus. By modifying and modernizing models of care for women with gestational diabetes mellitus, we have the ability to address accessibility, resource management and our acute response to global events such as the COVID 19 pandemic. With continuing research, education and robust discourse, Australia is well placed to meet current and future challenges in the management of gestational diabetes mellitus.
Environmental Policy Integration in the Energy Sector of China: The Roles of the Institutional Context
Authors: Ruan Xiang , Sheng Rong , Lin Tuo
Published: December 2020

The rapid growth of China’s renewable energy market and production capacity has attracted worldwide attention. Environmental policy integration in the energy sector and the institutional background behind this growth have seen little examination. In this paper, we present an assessment of environmental policy integration (EPI), attempting to reveal how the institutional factors facilitate EPI in the energy sector of China. A qualitative analytical framework involving normative, organizational, and procedural dimensions, incorporating multiple pieces of quantitative evidence, was applied. The results show that an ambitious and long-term normative vision covering political will, social backing, and cultural foundation in China is indispensable to the EPI process in the energy sector. The energy agency’s trans-sector cooperation in policy-making has been established to overcome the sectoral compartmentalization. China’s EPI in energy has a relatively complete and stable regulating system but, at the same time, it is expected to obtain more benefits from market cultivation and public participation. In this process, advantages such as the co-evolution of the green energy innovation, market, and society do exist; however, this market-oriented approach may bring the risk of economic and societal disturbances when interest-driven production capacity growth far surpasses market and societal requirements. This potential risk needs to be handled and prevented by strong governmental guidance and support. The continuous ambitious and long-term visioning of EPI, sufficient governmental funds, and a proactive industrial plan for renewable energy, are suggested.
Who Is Best to Test? A Systematic Review of Chlamydia Infections in Switzerland
Authors: Haag Melanie , Zemp Elisabeth , Hersberger Kurt E. , Arnet Isabelle
Published: December 2020

In many countries, community pharmacies provide sexual-health-related services to limit the spread of sexually transmitted infections (STIs), including chlamydia testing. To identify suitable target groups for pharmacy-based chlamydia testing in Switzerland, we aimed to assess chlamydia prevalence, identify risk groups, and delineate screening strategies. We conducted a systematic literature search up to December 2019 in PubMed, EMBASE, and Web of Science, according to the PRISMA guidelines, using as keywords “chlamydia”, “screening”, and “Switzerland”. Two researchers screened the title, abstract, and full-text article and assessed the methodological quality. The literature search generated 108 hits, and nine studies were included. Chlamydia prevalence ranged between 0.8 and 12.8%. Most frequently affected were undocumented women undergoing voluntary termination of pregnancy (12.8%, 95% CI: 8.4–18.9), HIV-positive men who have sex with men (10.9%, 95% CI: 9.2–17.6), and adult offenders (6.5%, 95% CI: 3.2–9.0). Systematic screening was suggested for the first two risk groups and women suffering a miscarriage. To conclude, chlamydia infections are prevalent in Switzerland, but the identified risk groups are difficult to reach for a pharmacy-based testing service. More studies are needed to identify suitable target groups, including customers seeking sexual health services, particularly emergency contraception users who already receive counselling for STIs at community pharmacies.
Distribution of Nitrate Content in Groundwater and Evaluation of Potential Health Risks: A Case Study of Rural Areas in Northern China
Authors: Feng Wenwen , Wang Chao , Lei Xiaohui , Wang Hao , Zhang Xueliang
Published: December 2020

Nitrate pollution is considered to be one of the most common environmental problems in groundwater, especially in areas affected by human mining, such as the arid region of northern China. However, the human health risk assessment of nitrate pollution in this area has not yet been carried out. In this study, groundwater samples were taken in the Selian mining area in Inner Mongolia to conduct a full analysis of water quality. On this basis, the groundwater quality, the distribution range of nitrate pollution, and human health risks were evaluated. The results show that the groundwater in the Selian mining area is neutral to alkaline, with high salinity and hardness. The concentration of nitrate ions in groundwater generally exceeds the standard, and the maximum exceeds 5.48 times the value specified in the Chinese national standard, indicating that groundwater nitrate pollution needs to be controlled urgently. Groundwater is polluted by large amounts of nitrogen fertilizer used by humans in agricultural activities. At the same time, mining activities have accelerated the severity and spread of pollution. Groundwater is not recommended for direct human life and irrigation use in the study area unless purification measures are taken. Nitrate pollution is more harmful to children through groundwater, about 1.54 times that of adults. Excess nitrate is transported into the body through drinking groundwater, so proper drinking water control will reduce the health risks of nitrate, such as centralized water supply. This study will provide a scientific basis for the rational use of groundwater and nitrate pollution control in the area.
Socioeconomic Profile of Tourists with a Greater Circular Attitude and Behaviour in Hotels of a Sun and Beach Destination
Authors: Rodríguez Carlos , Jacob Marta , Florido Carmen
Published: December 2020

This work aims to analyse the attitude towards circular economy (CE) and the environmental behaviour and circular practices among tourists of a well-known mature sun and beach destination. The study was conducted on a sample of tourists who visited Gran Canaria and stayed at a hotel establishment. Findings show that: (a) Older tourists have a higher pro-environmental or circular attitude in hotel establishments than younger ones; (b) most tourists are willing to pay more for environmentally friendly or green hotels and this is related to socio-demographic variables; (c) the majority of tourists believe that it is important for the hotel to have an energy-saving policy; (d) tourists’ attitude towards circular practices varies according to socio-economic profile; (e) the most common sustainable hotel practices carried out by tourists are the use of recycling bins and reusable towel and linen schemes; (f) women report a higher circular behaviour than men; and (g) 86.5% of tourists carry out the same CE practices on holidays as in their place of residence. Study findings could be useful to design the transition from a linear model to a circular model in the hotel industry of a destination as it identifies the areas that the industry must promote to reach this transition.
What Is the Relevance in the Passing Action between the Passer and the Receiver in Soccer? Study of Elite Soccer in La Liga
Authors: Cordón-Carmona Antonio , García-Aliaga Abraham , Marquina Moisés , Calvo Jorge Lorenzo , Mon-López Daniel , Refoyo Roman Ignacio
Published: December 2020

Soccer is a high-complexity sport in which 22 players interact simultaneously in a common space. The ball-holder interacts with their teammates by passing actions, establishing a unique communication among them in the development of the game in its offensive phase. The main aim of the present study was to analyze the pass action according to the trajectory of the ball receiver and the space for receiving the ball in terms of success at the end of play. Twenty La Liga 2018/2019 matches of two elite teams were analyzed. A system of notational analysis was used to create 11 categories based on context, timing and pass analysis. The data were analyzed using chi-squared analysis. The results showed that the main performance indicators were the efficiency of the pass, the zone of the field, the trajectory of the receiver and the reception space of the ball, which presented a moderate association with the end of play (p < 0.001). We concluded that receiving the ball on approach and in separation increased the probability of success by 5% and 7%, respectively, and a diagonal run increased the probability by 7%. Moreover, the combined analysis of these variables would improve the team performance.
Mental Health and Service Use of Migrants in Contact with the Public Psychiatry System in Paris
Authors: Tortelli Andrea , Perquier Florence , Melchior Maria , Lair François , Encatassamy Fabien , Masson Chloé , K’ourio Hélène , Gourevitch Raphaël , Mercuel Alain
Published: December 2020

Background: Migrants, and particularly asylum seekers, are at increased risk of psychiatric disorders in comparison with natives. At the same time, inequalities in access to mental health care are observed. Methods: In order to evaluate whether the Parisian public psychiatric system is optimally structured to meet the needs of this population, we examined data on mental health and service use considering three different levels: the global system treatment level, a psychiatric reception center, and mobile teams specializing in access to psychiatric care for asylum seekers. Results: We found higher treatment rates among migrants than among natives (p < 0.001) but inequalities in pathways to care: more mandatory admissions (OR = 1.36, 95% CI: 1.02–1.80) and fewer specialized consultations (OR = 0.56, 95% CI: 0.38–0.81). We observed a mismatch between increased need and provision of care among migrants without stable housing or seeking asylum. Conclusions: Inequalities in the provision of care for migrants are observed in the Parisian public psychiatric system, particularly for those experiencing poor social and economic conditions. There is a need to facilitate access to mental health care and develop more tailored interventions to reduce discontinuity of care.
Environmentally Friendly Quinolones Design for a Two-Way Choice between Biotoxicity and Genotoxicity through Double-Activity 3D-QSAR Model Coupled with the Variation Weighting Method
Authors: Sun Peixuan , Zhao Yuanyuan , Yang Luze , Ren Zhixing , Zhao Wenjin
Published: December 2020

Quinolone (QN) antibiotics are widely used, which lead to their accumulation in soil and toxic effects on ryegrass in pasture. In this study, we employed ryegrass as the research object and selected the total scores of 29 QN molecules docked with two resistant enzyme structures, superoxide dismutase (SOD, PDB ID: 1B06) and proline (Pro, PPEP-2, PDB ID: 6FPC), as dependent variables. The structural parameters of QNs were used as independent variables to construct a QN double-activity 3D-QSAR model for determining the biotoxicity on ryegrass by employing the variation weighting method. This model was constructed to determine modification sites and groups for designing QNs molecules. According to the 3D contour map of the model, by considering enrofloxacin (ENR) and sparfloxacin (SPA) as examples, 23 QN derivatives with low biotoxicity were designed, respectively. The functional properties and environmental friendliness of the QN derivatives were predicted through a two-way selection between biotoxicity and genotoxicity before and after modification; four environmentally friendly derivatives with low biotoxicity and high genotoxicity were screened out. Mixed toxicity index and molecular dynamics methods were used to verify the combined toxicity mechanism of QNs on ryegrass before and after modification. By simulating the combined pollution of ENR and its derivatives in different soils (farmland, garden, and woodland), the types of combined toxicity were determined as partial additive and synergistic. Binding energies were calculated using molecular dynamics. The designed QN derivatives with low biotoxicity, high genotoxicity, and environmental friendliness can highly reduce the combined toxicity on ryegrass and can be used as theoretic reserves to replace QN antibiotics.
Low Health Literacy and Mortality in Individuals with Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, Diabetes, and Mental Illness: A 6-Year Population-Based Follow-Up Study
Authors: Friis Karina , Aaby Anna , Lasgaard Mathias , Pedersen Marie Hauge , Osborne Richard H. , Maindal Helle Terkildsen
Published: December 2020

Background: The objective of the study was to examine the impact of health literacy on mortality in the general population and among individuals with cardiovascular disease (CVD), chronic obstructive pulmonary disease (COPD), diabetes, and mental illness. Methods: Data from a large Danish health survey (n = 29,473) from 2013 were linked with national mortality registry data to permit a 6-year follow-up. Results: Individuals reporting difficulties in understanding information about health, had higher risk of dying during follow-up (hazard rate (HR) 1.38 (95% CI 1.11–1.73)) compared with those without difficulties. Higher risk was also observed among people reporting CVD (HR 1.47 (95% CI 1.01–2.14)), diabetes (HR 1.91 (95% CI 1.13–3.22)) and mental illness (HR 2.18 (95% CI 1.25–3.81)), but not for individuals with COPD. Difficulties in actively engaging with healthcare providers was not associated with an increase in the risk of dying in the general population or in any of the four long-term condition groups. Conclusions: Aspects of health literacy predict a higher risk of dying during a 6-year follow-up period. Our study serves as a reminder to healthcare organizations to consider the health literacy responsiveness of their services in relation to diverse health literacy challenges and needs.
Adipose Tissue and Endocrine-Disrupting Chemicals: Does Sex Matter?
Authors: Le Magueresse-Battistoni Brigitte
Published: December 2020

Obesity and metabolic-related diseases, among which diabetes, are prominent public health challenges of the 21st century. It is now well acknowledged that pollutants are a part of the equation, especially endocrine-disrupting chemicals (EDCs) that interfere with the hormonal aspect. The aim of the review is to focus on adipose tissue, a central regulator of energy balance and metabolic homeostasis, and to highlight the significant differences in the endocrine and metabolic aspects of adipose tissue between males and females which likely underlie the differences of the response to exposure to EDCs between the sexes. Moreover, the study also presents an overview of several mechanisms of action by which pollutants could cause adipose tissue dysfunction. Indeed, a better understanding of the mechanism by which environmental chemicals target adipose tissue and cause metabolic disturbances, and how these mechanisms interact and sex specificities are essential for developing mitigating and sex-specific strategies against metabolic diseases of chemical origin. In particular, considering that a scenario without pollutant exposure is not a realistic option in our current societies, attenuating the deleterious effects of exposure to pollutants by acting on the gut-adipose tissue axis may constitute a new direction of research.
Corona-Triggered Global Macroeconomic Crisis of the Early 2020s
Authors: Krstic Kristijan , Westerman Ronny , Chattu Vijay Kumar , V. Ekkert Natalia , Jakovljevic Mihajlo
Published: December 2020

Long-lasting economic recessions spreading from initial cradle markets worldwide should be a periodic event inherent to capitalism as a prevailing socio-economic model [...]
Analysis of the Temporal Characteristics of the Elderly Traveling by Bus Using Smart Card Data
Authors: Shi Zhicheng , Pun-Cheng Lilian S. C. , Liu Xintao , Lai Jianhui , Tong Chengzhuo , Zhang Anshu , Zhang Min , Shi Wenzhong
Published: December 2020

Many cities around the world face the challenge of an aging population. A full understanding of the mobility behavior characteristics of the elderly is one necessary and urgent consideration as regards the current aging trend if sustainable urban development is to be fully realized. This paper presents a systematic approach to analyzing the dynamic mobility characteristics of the elderly who travel by bus using smart card big data. The characteristics include temporal distribution, travel distance, travel duration, travel frequency, and also the spatial distribution of such travelers. The findings of these mobility characteristics can directly contribute to both public transport policy making, service, and management. In this study, the analytics of the elderly are also compared with that of the average adult group so as to identify both the similarities and differences between the two groups. Beijing, a megacity, with a very high life expectancy and in which the bus is the dominant mode of public transport for the elderly, was used as the study area. The significance of this research concerns a newly developed systematic approach that is able to analyze the dynamic mobility characteristics of the elderly using smart card data.
RETRACTED: Han et al. Contact/Release Coordinated Antibacterial Cotton Fabrics Coated with N-Halamine and Cationic Antibacterial Agent for Durable Bacteria-Killing Application. Int. J. Mol. Sci. 2020, 21, 6531
Authors:   International Journal of Molecular Sciences Editorial Office
Published: December 2020

We have been made aware that a number of figures in the paper cited above [...]
Hypoxia-Mediated Decrease of Ovarian Cancer Cells Reaction to Treatment: Significance for Chemo- and Immunotherapies
Authors: Klemba Aleksandra , Bodnar Lubomir , Was Halina , Brodaczewska Klaudia K. , Wcislo Gabriel , Szczylik Cezary A. , Kieda Claudine
Published: December 2020

Hypoxia, a common factor ruling the microenvironment composition, leads to tumor progression. In this hypoxic context, cytokines and cells cooperate to favor cancer development and metastasis. Tumor hypoxia is heterogeneously distributed. Oxygen gradients depend on the vicinity, functionality of blood vessels, and oxygen ability to diffuse into surrounding tissues. Thus, the vasculature state modulates the microenvironment of the tumor cells. Cells sense and react to small variations in oxygen tension, which explains the lack of tumor cells’ unicity in their reaction to drugs. Ovarian cancers are highly hypoxia-dependent, ascites worsening the access to oxygen, in their reactions to both chemotherapy and new immunotherapy. Consequently, hypoxia affects the results of immunotherapy, and is thus, crucial for the design of treatments. Controlling key immunosuppressive factors and receptors, as well as immune checkpoint molecule expression on tumor, immune and stromal cells, hypoxia induces immunosuppression. Consequently, new approaches to alleviate hypoxia in the tumor microenvironment bring promises for ovarian cancer immunotherapeutic strategies. This review focuses on the effects of hypoxia in the microenvironment and its consequences on tumor treatments. This opens the way to innovative combined treatments to the advantage of immunotherapy outcome in ovarian cancers.
Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease
Authors: Stec David E. , Hinds Terry D.
Published: December 2020

Heme oxygenase (HO) is a critical component of the defense mechanism to a wide variety of cellular stressors. HO induction affords cellular protection through the breakdown of toxic heme into metabolites, helping preserve cellular integrity. Nonalcoholic fatty liver disease (NAFLD) is a pathological condition by which the liver accumulates fat. The incidence of NAFLD has reached all-time high levels driven primarily by the obesity epidemic. NALFD can progress to nonalcoholic steatohepatitis (NASH), advancing further to liver cirrhosis or cancer. NAFLD is also a contributing factor to cardiovascular and metabolic diseases. There are currently no drugs to specifically treat NAFLD, with most treatments focused on lifestyle modifications. One emerging area for NAFLD treatment is the use of dietary supplements such as curcumin, pomegranate seed oil, milk thistle oil, cold-pressed Nigella Satvia oil, and resveratrol, among others. Recent studies have demonstrated that several of these natural dietary supplements attenuate hepatic lipid accumulation and fibrosis in NAFLD animal models. The beneficial actions of several of these compounds are associated with the induction of heme oxygenase-1 (HO-1). Thus, targeting HO-1 through dietary-supplements may be a useful therapeutic for NAFLD either alone or with lifestyle modifications.
Role of Hibernation Promoting Factor in Ribosomal Protein Stability during Pseudomonas aeruginosa Dormancy
Authors: Theng Sokuntheary , Williamson Kerry S. , Franklin Michael J.
Published: December 2020

Pseudomonas aeruginosa is an opportunistic pathogen that causes biofilm-associated infections. P. aeruginosa can survive in a dormant state with reduced metabolic activity in nutrient-limited environments, including the interiors of biofilms. When entering dormancy, the bacteria undergo metabolic remodeling, which includes reduced translation and degradation of cellular proteins. However, a supply of essential macromolecules, such as ribosomes, are protected from degradation during dormancy. The small ribosome-binding proteins, hibernation promoting factor (HPF) and ribosome modulation factor (RMF), inhibit translation by inducing formation of inactive 70S and 100S ribosome monomers and dimers. The inactivated ribosomes are protected from the initial steps in ribosome degradation, including endonuclease cleavage of the ribosomal RNA (rRNA). Here, we characterized the role of HPF in ribosomal protein (rProtein) stability and degradation during P. aeruginosa nutrient limitation. We determined the effect of the physiological status of P. aeruginosa prior to starvation on its ability to recover from starvation, and on its rRNA and rProtein stability during cell starvation. The results show that the wild-type strain and a stringent response mutant (∆relA∆spoT strain) maintain high cellular abundances of the rProteins L5 and S13 over the course of eight days of starvation. In contrast, the abundances of L5 and S13 reduce in the ∆hpf mutant cells. The loss of rProteins in the ∆hpf strain is dependent on the physiology of the cells prior to starvation. The greatest rProtein loss occurs when cells are first cultured to stationary phase prior to starvation, with less rProtein loss in the ∆hpf cells that are first cultured to exponential phase or in balanced minimal medium. Regardless of the pre-growth conditions, P. aeruginosa recovery from starvation and the integrity of its rRNA are impaired in the absence of HPF. The results indicate that protein remodeling during P. aeruginosa starvation includes the degradation of rProteins, and that HPF is essential to prevent rProtein loss in starved P. aeruginosa. The results also indicate that HPF is produced throughout cell growth, and that regardless of the cellular physiological status, HPF is required to protect against ribosome loss when the cells subsequently enter starvation phase.
TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection
Authors: Kim Dong Oh , Byun Jae-Eun , Kim Won Sam , Kim Mi Jeong , Choi Jung Ha , Kim Hanna , Choi Eunji , Kim Tae-Don , Yoon Suk Ran , Noh Ji-Yoon , Park Young-Jun , Lee Jungwoon , Cho Hee Jun , Lee Hee Gu , Min Sang-Hyun , Choi Inpyo , Jung Haiyoung
Published: December 2020

The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the production of IFN-γ in NK cells during bacterial infection. TXNIP inhibited the production of IFN-γ and the activation of transforming growth factor β-activated kinase 1 (TAK1) activity in primary mouse and human NK cells. TXNIP directly interacted with TAK1 and inhibited TAK1 activity by interfering with the complex formation between TAK1 and TAK1 binding protein 1 (TAB1). Txnip−/− (KO) NK cells enhanced the activation of macrophages by inducing IFN-γ production during Pam3CSK4 stimulation or Staphylococcus aureus (S. aureus) infection and contributed to expedite the bacterial clearance. Our findings suggest that NK cell-derived IFN-γ is critical for host defense and that TXNIP plays an important role as an inhibitor of NK cell-mediated macrophage activation by inhibiting the production of IFN-γ during bacterial infection.
Maize microRNA166 Inactivation Confers Plant Development and Abiotic Stress Resistance
Authors: Li Na , Yang Tianxiao , Guo Zhanyong , Wang Qiusheng , Chai Mao , Wu Mingbo , Li Xiaoqi , Li Weiya , Li Guangxian , Tang Jihua , Tang Guiliang , Zhang Zhanhui
Published: December 2020

MicroRNAs are important regulators in plant developmental processes and stress responses. In this study, we generated a series of maize STTM166 transgenic plants. Knock-down of miR166 resulted in various morphological changes, including rolled leaves, enhanced abiotic stress resistance, inferior yield-related traits, vascular pattern and epidermis structures, tassel architecture, as well as abscisic acid (ABA) level elevation and indole acetic acid (IAA) level reduction in maize. To profile miR166 regulated genes, we performed RNA-seq and qRT-PCR analysis. A total of 178 differentially expressed genes (DEGs) were identified, including 118 up-regulated and 60 down-regulated genes. These DEGs were strongly enriched in cell and intercellular components, cell membrane system components, oxidoreductase activity, single organism metabolic process, carbohydrate metabolic process, and oxidation reduction process. These results indicated that miR166 plays important roles in auxin and ABA interaction in monocots, yet the specific mechanism may differ from dicots. The enhanced abiotic stress resistance is partly caused via rolling leaves, high ABA content, modulated vascular structure, and the potential changes of cell membrane structure. The inferior yield-related traits and late flowering are partly controlled by the decreased IAA content, the interplay of miR166 with other miRNAs and AGOs. Taken together, the present study uncovered novel functions of miR166 in maize, and provide insights on applying short tandem target mimics (STTM) technology in plant breeding.