bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of novel compound mutations of SLC12A3 gene in a Chinese pedigree with Gitelman's syndrome exhibiting Bartter's syndrome-liked phenotypes
Authors: Bingzi Dong , Ying Chen , Xinying Liu , Yangang Wang , Fang Wang , Yuhang Zhao , Xiaofang Sun , Zhao Wenjuan
Published: April 2020

Background

Gitelman's syndrome (GS) is a rare salt-losing renal tubular disorder associated with SLC12A3 gene mutations, which encodes the Na-Cl co-transporter (NCCT). GS is characterized by hypokalaemic metabolic alkalosis, hypomagnesemia, hypocalciuria and elevated renin-angiotensin-aldosterone (RAA) level. The variability of phenotypes is likely to be associated with the variety of SLC12A3 mutations.

Methods

In this study, we reported the clinical features and the genetic analysis of a GS family pedigree.

Results

We identified novel mutations of SLC12A3 , with c.433 C>T (p.Arg145Cys), c.1077 C>G (p.Asn359Lys), and c.1666 C>T (p.Pro556Ser). The proband exhibited hypokalaemia, hypomagnesemia, metabolic alkalosis, but hypercalcuria and kidney stone. The increased urinary calcium excretion made it confused to Bartter's syndrome (BS). The persistent renal potassium wasting associated renal tubular lesions finally affected urinary calcium reabsorption, leading to the increased calcium excretion. Genetic analysis revealed mutations of SLC12A3 with C433T (Arg145Cys, Het), C1077G (Asn359Lys, Het), and C1666T (Pro556Ser, Het). Those missense mutations led to the predicted amino acid change, caused differences of NCCT protein structures and function. One sister of the proband carried the same mutant sites, however, exhibited milder phenotypes including hypokalemia, hypomagnesemia, RAAS activation, but not elevated urinary calcium excretion. With administration of antisterone, potassium chloride and magnesium supplement, the serum potassium and magnesium were maintained in normal ranges.

Conclusions

In this study, we identified the novel mutations of SLC12A3 and the varieties of clinical features. Further efforts are needed to investigate the diversity in clinical manifestations of GS and its correlation with SLC12A3 mutations.
WITHDRAWN: Elucidating the Mechanisms of Action of Chinese Medicine for the Treatment of COVID-19 via Systems Pharmacology and Virtual Screening Approaches
Authors: Wang Xiting , Liu Meng , Quin Caimeng , Qu Rendong , Lu Tao
Published: April 2020

The novel coronavirus disease 2019 (COVID-19) epidemic is threatening public health security in China. Owing to the severity of this epidemic, identifying a proper treatment for COVID-19 is crucial. Although the Quing-Fei-Pai-Du (QFPD) decoction preliminary displayed promising clinical efficacy, its potential biological mechanism has not been explored for further pharmaceutical development and treatment. Through systems pharmacology and virtual screening approaches, we explored the potential mechanism of action and the active ingredients of the QFPD decoction for COVID-19 treatment. A ingredients-targets dataset was generated. ADME/Tox and molecular docking analyses were conducted to screen the potentially-active ingredients. Protein-protein interaction network and the detection algorithm were applied to dynamically identify functionally-relevant protein groupings. Totally, 705 ingredients and 1,489 targets were obtained. Docking revealed that 40 components could be promising active ingredients, 6 of which (Neohesperidin, Naringenin, Liquiritigenin, Apigenin, Isoquercitrin and Herbacetin), were highlighted according to the comprehensive analysis. The enrichment analysis of the highlighted ingredients showed that several significant pathways could be highly related to their mechanisms of action, such as response to oxygen levels, response to oxidative stress, and blood circulation. Overall, our findings suggest the promising effects of the QFPD decoction for COVID-19 treatment. Further experimental and clinical verifications are needed.Authors Xiting Wang and Meng Liu contributed equally to this work.
Modeling hydro-climatic changes of evapotranspiration over a semi-arid river basin of India
Authors: Rehana S. , Sireesha Naidu G. , Monish N. T. , Sowjanya U.
Published: April 2020

Parametric models of actual evapotranspiration (AET) based on precipitation (P) and potential evapotranspiration (PET) are region-specific and purely climate-induced and limited to represent the hydrological water balances. Basin-averaged model parameters considering P, AET, and runoff (R) using a machine learning algorithm, ensemble regression model, is proposed. Hydrologically calibrated model parameters allowed the study of AET under alterations of water use for current and for future scenarios under climate change. The effect of climate, water, and land use changes on AET was studied for the post-change period of 2004–2014 compared to pre-change period of 1965–2003 over Krishna river basin (KRB), India. The AET has increased under climate and water use changes while there is both increase and decreases of AET under land use changes for post-change period compared to pre-change period over the basin. Severe water shortages were estimated under pronounced increase of temperature (1.29 °C) compared to precipitation increase (2.19%) based on Coordinated Regional Downscaling Experiment (CORDEX) projections for the period 2021–2060. Hydrologically induced AET changes were more pronounced than climate for current climate; whereas climate-induced AET changes were found to be more prominent for projected climate signals over the basin.
Approaches to the study of international migration: a review
Authors: Cuamea Velázquez Felipe
Published: April 2020

This review essay addresses research questions, hypotheses, assumptions, contributions, and shortcomings of predominant approaches to the study of international migration. The discussion concludes with some reflections on future research, particularly on the need to integrate different perspectives.
El tratado de libre comercio y la ganadería bovina de carne de la región fronteriza de Coahuila
Authors: Vidaurrázaga Obezo Francisco René , Cortez Lara Alfonso Andrés
Published: April 2020

El presente trabajo tiene como objetivo analizar la ganadería bovina de carne de la región fronteriza de Coahuila, su importancia en el sector agropecuario de la entidad, así como los efectos del TLC en esta rama pecuaria y sus perspectivas en el corto, mediano y largo plazos. La ganadería bovina de la región fronteriza de Coahuila, con la operación del TLC atraviesa por una serie de problemas que no le permiten ser competitiva en el corto y mediano plazos. Entre los principales problemas, se puede mencionar que la mayoría de las unidades de producción ganadera presentan un alto grado de endeudamiento con la banca comercial y no tienen solvencia para capitalizar la actividad en el corto plazo, quedando en desventaja con los productores estadounidenses.
Reestructuración econónomica y regiones emergentes: Baja California, 1980-1995
Authors: Ranfla González Arturo
Published: April 2020

Este ensayo tiene como propósito hacer una discusión de los niveles políticos y territoriales involucrados en el proceso de globalización económica en la región fronteriza del norte de México y en particular el estado de Baja California, haciendo una aproximación de las condiciones económicas y sectoriales de la economía bajacaliforniana durante el periodo 1981-1994. Así como un análisis detallado de la estructura y dinámica sectorial de la producción —durante el mismo periodo—, de los principales municipios en Baja California para identificar el perfil y la jerarquía de cada uno de ellos.
Análisis económico del costo de vida en la frontera norte de Coahuila
Authors: Vázquez Delgado Blanca
Published: April 2020

El objetivo de este trabajo es realizar una reflexión acerca del cambio de estrategia en la determinación del salario y la ruptura de su relación con la canasta básica y el poder adquisitivo de los trabajadores. Pretendemos evidenciar el caso particular de las ciudades en la frontera norte de Coahuila. Bajo la nueva estrategia de desarrollo en el ámbito de los salarios, dada la pérdida de relación de éste con el costo de vida de la población y sus necesidades básicas, el logro de los objetivos de equilibrio macroeconómico ha sido a través de la contención salarial; sin embargo, esta estrategia no ha traído otro resultado más que la mayor pérdida de bienestar de la población. Los cambios habidos en la política salarial, han mermado la capacidad de gran parte de la población de acceder a los elementos necesarios de satisfacción básica, situación que se agrava más considerando las diferencias en el costo económico de vivir en determinadas ciudades, concretamente en ciudades fronterizas.
Región y globalización: el problema de la identidad
Authors: Balbuena Bello Raúl
Published: April 2020

En este documento se presenta una reflexión sobre la relación que se establece entre región, globalización e identidad. artiendo de una interpretación en cuanto a identidad se refiere, el objetivo aquí, es mostrar que el proceso de globalización en tanto dominante, no tiende a desaparecer a la región, antes bien, la reafirma. Procesos financieros y productivos sostenidos a través de los lineamientos de la libre competencia aparecen como elementos que van a caracterizar más profundamente el proceso de regionalización. En lo que al caso de nuestro territorio hace, la frontera norte es un ejemplo claro de lo que la región representa en el proceso de globalización. La identidad regional no subyace a la globalización, la frontera norte así lo manifiesta, los procesos laborales y la cercanía con el país más poderoso del mundo representa una enorme ventaja para los intereses del capital privado transnacional que llegan a establecer sus empresas a lo largo de la frontera norte. Así pues, el norte del país se enfunda en una identidad especial a partir de exigencias globalizantes. Es entonces que la región y la globalización aparecen en este documento como un problema de la identidad (o de identidades si se requiere).
De comunidades inventadas a comunidades invisibles: hacia un marco teórico para el estudio de los Yumanos de Baja California
Authors: Garduño Everardo
Published: April 2020

Este articulo es una aproximación al proceso de construcción de redes sociales y etnicidad entre los indígenas yumanos de Baja California, México. A partir de su cuestionamiento a los enfoques tradicionales que reiteradamente han anunciado la extinción y asimilación de estos grupos, este articulo sugiere un nuevo marco teórico para el estudio de la supuesta disipación de estas poblaciones étnicamente diferenciadas. Conceptos centrales de esta propuesta teórica son los conceptos de comunidad transnacional, hiperespacio y polibio, los cuales según el autor, aplicados al trabajo de campo, pueden conducirnos a revelar las formas en que los yumanos permanecen comprometidos en la elaboración de nuevas formas de organización social y auto-referencia étnica, a través de la construcción de amplias redes sociales que incluyen (aunque no se limitan) a los grupos lingüísticamente relacionados que habitan en los Estados Unidos.
Más allá de la frontera: penetración del estado-nación, TLC y control externo en la industria México-Americana del mango
Authors: Álvarez Robert R.
Published: April 2020

Al abordar el caso de la industria del mango en México y Estados Unidos, este escrito explora el compromiso que tiene el Estado-nación en la actividad trasnacional a través de las funciones que realiza el Departamento de Agricultura estadounidense, cuya labor de control y certificación de los mangos que son importados a ese país, es parte de un sistema más amplio que incluye al TLC y una ya histórica inmigración de mano de obra que ha inducido a nuevos mercados para “productos étnicos”. Esto, a su vez, es parte de un sistema hemisférico más amplio ligado a las prerrogativas de los Estados Unidos. Aunque el Departamento de Agricultura estadounidense –al igual que otras agencias gubernamentales fronterizas– controla el ingreso de productos agrícolas a la frontera geopolítica entre México y los Estados Unidos, la intromisión de esta agencia en las políticas internas de México y su control fuera de los límites de su territorio en cuanto a la producción y distribución de productos agrícolas, no suele ser un tema de investigación.
El medio ambiente en la frontera México-Estados Unidos: ¿las ONG ambientalistas, nuevos actores sociales?
Authors: Alfie Cohen Miriam
Published: April 2020

El artículo destaca el papel que las Organizaciones no Gubernamentales han desempeñado frente al deterioro ambiental en la región fronteriza que compartimos con los Estados Unidos. El propósito es mostrar los alcances y los logros, así como los retos y las metas de estos nuevos actores sociales. Si coincidimos en que el deterioro ambiental es uno de los asuntos globales, que se presenta como preocupación inminente tanto en los países del Norte como en los del Sur, la frontera México-Estados Unidos es un excelente laboratorio de pruebas para comprobar no sólo la existencia y acción de nuevos grupos y sujetos sociales, sino también poner en la mesa de discusión el deterioro, caos y peligro ambiental de la región compartida con los Estados Unidos.
Contribución andaluza a la formación de un espacio transfronterizo en la frontera hispano-marroquí
Authors: Jordá Borrel Rosa
Published: April 2020

En este artículo nos vamos a centrar en la manera en que está evolucionado el flujo del comercio exterior entre Andalucía y Marruecos, y cuáles han sido las estrategias de los agentes económicos andaluces para penetrar en el mercado marroqu aprovechando la expansión de la demanda y los bajos precios de la mano de obra, todo ello teniendo en cuenta que la zona de librecambio se inició en 1996 y todavía no ha pasado tiempo suficiente para hacer un análisis profundo de la cuestión. En segundo lugar, queremos medir el nivel de participación de la Comunidad Autónoma Andaluza en la construcción de infraestructura (puertos, centrales eléctricas, térmicas, aeropuertos, telecomunicaciones, sanidad) y equipamiento para colectividades locales, regionales y nacionales marroquíes, puesto que constituye otra forma de penetración en el mercado alauita, y puede considerarse también una manera de conocer la participación de Andalucía en el proceso de desarrollo de la zona de libre comercio marroquí, ya que está inserta doblemente en dicho proceso, como región de la Unión Europea (UE) y por ser puerta de Europa.
Configuración parlamentaria y productividad legislativa en el congreso de Baja California
Authors: López Guzmán Cuauhtémoc
Published: April 2020

Este trabajo presenta un análisis estático y dinámico del Congreso del Estado de Baja California. El enfoque estático aborda el origen histórico del congreso, sus facultades constitucionales y la composición partidista. El enfoque dinámico integra un estudio comparativo de la productividad legislativa en dos grandes periodos: el periodo de gobierno unificado (1953-1989) y el periodo de gobiernos divididos (1989-2001). Además, se construyeron indicadores para analizar la dinámica parlamentaria bajo el formato de mayorías divididas con el propósito de racionalizar las condiciones institucionales, políticas y partidistas que determinan la conducta del legislador. Estas conductas propician entre el poder legislativo y ejecutivo periodos de cooperación y conflicto que afectan el rendimiento institucional y la gobernabilidad.
Entre o Céu e o Inferno
Authors: Medeiros de Oliveira Naiara , De Andrade Tosta Antonio Luciano
Published: April 2020

A emigração de brasileiros para os Estados Unidos tem aumentado consideravelmente nas últimas três décadas. Dessa forma, imigrantes Brasileiros passaram a usar a literatura, música e o cinema como uma forma de expressão de suas experiências. Após discutir rapidamente acerca da mudança do Brasil como uma terra de imigração para uma região de emigração, o presente ensaio introduz inúmeros aspectos da literatura Brazuca e analisa como a experiência americana tem criado mudanças de percepção sobre o Brasil e os Estados Unidos para esse novo grupo minoritário, que se torna uma característica do seu entre-lugar como imigrantes.
Uma porção do Japão em Campo Grande (MS)?
Authors: Cruz Ricardo Luiz , Toyama Juliana
Published: April 2020

O sobá é um prato, normalmente consumido de forma individual, composto por caldo de carne suína, omelete cortado em finas tiras, carne bovina ou suína, cebolinha, gengibre e uma massa de macarrão preparada com cinzas de legumes.  Este artigo busca analisar o sobá como experiência, memória e imaginário. O foco é no sobá produzido e consumido na Feira Central e Turística de Campo Grande (MS) – um espaço localizado no centro da cidade e onde a experiência da sua degustação, enquanto algo “turístico”, ganha sentido através de um imaginário também expresso na paisagem do local e ancorado numa memória sobre a imigração japonesa no sul do antigo estado de Mato Grosso.
Rosa dos ventos no peito: mulheres, viagens e contracultura
Authors: Kaminski Leon , Vieira Danusa
Published: April 2020

Nas décadas de 1960 e 1970, era possível ver jovens viajando de carona, com mochilas às costas. Eram os tempos da contracultura, em que parte da juventude procurava construir estilos de vida alternativos, e viajar era visto como uma prática que permitia “cair fora” do sistema. Neste artigo, procuramos analisar a presença das mulheres no universo das viagens contraculturais, discutindo as relações de gênero implicadas no contexto da vida estradeira e de suas práticas. Ao trazer para o contexto brasileiro, buscamos entender quem são essas mochileiras, suas motivações, suas táticas específicas, apresentando a conjuntura que possibilitou a essas mulheres transgredir os estereótipos do feminino, em uma sociedade que sofria profundas transformações.
Resveratrol Regulates Nrf2-Mediated Expression of Antioxidant and Xenobiotic Metabolizing Enzymes in Pesticides-Induced Parkinsonism
Authors: Rasheed Mohd Sami Ur , Tripathi Manish Kumar , Patel Devendra Kumar , Singh Mahendra Pratap
Published: April 2020

Background:

Combined maneb (MB) and paraquat (PQ), two widely used pesticides, increases
oxidative stress leading to Parkinsonism. Xenobiotic metabolizing enzymes, cytochrome
P450 (CYP) 2D6 and its mouse ortholog Cyp2d22 protect against Parkinsonism. Resveratrol, an antioxidant,
restores antioxidant defense system through the activation of nuclear factor erythroid 2-
related factor 2 (Nrf2). However, a crosstalk between Cyp2d22/CYP2D6-mediated protection and
resveratrol-induced Nrf2 activation leading to neuroprotection is not yet elucidated.

Objective:

The study aimed to decipher the effect of resveratrol on Nrf2 activation and expression
of its downstream mediators, nicotinamide adenine dinucleotide phosphate quinone oxidoreductase
1 (NQO1) and thioredoxin 1 (Trx1) along with Cyp2d22/CYP2D6 activity in combined MB and
PQ mouse model of Parkinsonism and differentiated neuroblastoma cells.

Results:

MB and PQ reduced the dopamine content (mouse) and Cyp2d22/CYP2D6 activity
(mouse/neuroblastoma cells) and increased the nuclear translocation of Nrf2 and expression of
NQO1 and Trx1 (both). Resveratrol ameliorated pesticides-induced changes in dopamine content
and Cyp2d22/CYP2D6 activity. It was found to promote nuclear translocation of Nrf2 and expression
of NQO1 and Trx1 proteins. Since Cyp2d22/CYP2D6 inhibitor (ketoconazole/quinidine) per
se reduced Cyp2d22/CYP2D6 activity and dopamine content, it was found to substantially increase
the pesticides-induced reduction in Cyp2d22/CYP2D6 activity and dopamine content. Inhibitors
normalized the pesticides induced changes in Nrf2 translocation and NQO1 and Trx1 levels in pesticides
treated groups.

Conclusion:

The results suggest that resveratrol promotes the catalytic activity of xenobiotic metabolizing
enzyme, Cyp2d22/CYP2D6, which partially contributes to Nrf2 activation in pesticides-
induced Parkinsonism.
Analog Rice Reduces Weight and Total Cholesterol Levels in Overweight and Hypercholesterolemic Rats
Authors: Dewantari Septiarina Putri , Hairrudin Hairrudin , Sakinah Elly Nurus
Published: April 2020

Overweight, whose prevalence is increasing, is caused by unbalanced consumption patterns such as high consumption of fat and can trigger hypercholesterolemia. Analog rice (AR), which has better nutritional content than ordinary rice, is thought to have beneficial effects on health. This study aimed to determine the potential of analog rice in reducing body weight and total cholesterol levels. A total of 24 male Wistar rats were divided into four groups, namely: I) control, II) ordinary rice treatment, III) analog rice 1 treatment (PBA1) and IV) analog rice 2 treatment (PBA2). The control group was given standard feed for 40 days ad libitum. Groups II, III, and IV were given a combination induction of high-fat diet (HFD) for 40 days ad libitum and intraperitoneal injection of streptozotocin (STZ) 35 mg/kg single dose on day 33. All groups were then given the treatment of diet for three weeks according to their respective groups, namely the standard, ordinary rice, analog rice 1, and analog rice 2 feed. Body weight and total cholesterol levels were measured in the pre-induction, post-induction/pre-treatment (pre-test), and post-treatment (post-test). The results of the study showed that the induction of the HFD-STZ combination carried out resulted in a significant increase in body weight and total cholesterol levels. Measurements made after dietary therapy showed that body weight and total cholesterol levels in the I and II groups did not change significantly, whereas those in the III and IV groups decreased significantly (p<0.05). This study concluded that the administration of analog rice could reduce body weight and total cholesterol levels in overweight and hypercholesterolemia rats.Â
Analysis of Cell Block and Cytology Specimen Preservation from Lung Aspiration Biopsy
Authors: Poernomo Adinda Sandya , Sandhika Willy , Budipramana Vicky Sumarki
Published: April 2020

Cytology smear technique is often used in Indonesia because the process is safe, simple, easy, fast, and cost effective. At present, several studies have found that smears with cell block techniques are of better quality than smears with cytology smear techniques. The aim of this study was to analyze whether the cytology smear technique can produce adequate specimens compared to cell block towards results of lung Fine Needle Aspiration Biopsy (FNAB). Lung FNAB specimens were divided into two parts: one part was processed with cytology and the other part with cell block technique. The specimens were observed under a microscope to count the number of inflammatory cells and the number of artifacts. The numbers of inflammatory cells and artifacts were scored 0-3. The inflammatory cells consisted of neutrophils, lymphocytes and plasma cells, also macrophages. The result showed no significant difference between the number of inflammatory cells in cytology and cell block (p neutrophils=0.543; p lymphocytes and plasma cells=0.192; p macrophages=0.487) in 38 samples. The artifact score comparison test result showed a significant difference between the number of artifacts in cytology and cell block (p=0.027) with more artifacts in cytology. The most common artifact in cytology was air bubble artifacts, while cell block was dominated by torn pieces artifacts. There was no significant difference between the number of inflammatory cells found in cytology and cell block techniques. Cell block technique has less artifacts than cytology, but artifacts found in cytology can be corrected so that the cytology smear technique is still an option.
Relationship of TTF-1 and EGFR on Lung Adenocarcinoma at Dr. Saiful Anwar General Hospital Malang
Authors: Lumban gaol Andy , Pratiwi Suryanti Dwi , Putra Ngakan Putu , Norahmawati Eviana , Rasyid Harun Al
Published: April 2020

There is a correlation between mutation of Epidermal Growth Factor Receptor (EGFR) and lung adenocarcinoma. Unfortunately, examination for EGFR mutation is difficult because surgery must be conducted to obtain the best specimen. Thyroid Transcription Factor-1 (TTF-1) is a marker for lung adenocarcinoma. This observational study took place at Dr. Saiful Anwar Hospital from stored biological materials from 2013-2018. Samples were lung adenocarcinoma patients that undergo EGFR examination. Data then analyzed using Fischer's Exact Test to determine the relationship between EGFR and TTF-1. Specificity/sensitivity value is 0.75/0.90, p: 0.617, odds ratio 0.333 (0.032-3.515). However, Receiver Operating Characteristic (ROC) curve of TTF- 1 show AUC 0.614 (95CI, 0.35- 0.878). TTF-1 examination has a moderate strength in determining EGFR mutation on lung adenocarcinoma patients at Dr. Saiful Anwar Hospital.Â  Â  Â  Â  Â
КЛІНІЧНА ОЦІНКА ЕФЕКТИВНОСТІ РОЗРОБЛЕНОГО ПРОФІЛАКТИЧНОГО КОМПЛЕКСУ ДЛЯ РОБІТНИКІВ, ЯКІ ПІДДАЮТЬСЯ ВПЛИВУ ЕЛЕКТРОМАГНІТНОГО ВИПРОМІНЮВАННЯ
Authors: Марковська І. В. , Соколова І. І.
Published: April 2020

Резюме. Стрімкий розвиток науково-технічного прогресу, а також поява різних електромагнітних випромінювань змушує організм людини перебувати в певному навколишньому середовищі, яке, на жаль, чинить негативний вплив на стан його систем і органів.

В останні роки стоматологи відзначають різні прояви негативного впливу електромагнітних полів на органи і тканини порожнини рота, які характеризується порушенням мінерального обміну в твердих тканинах зубів, гіперестезією, появою вогнищ демінералізації, змінами з боку слизової оболонки рота, гіпосалівацією.

Вищенаведені дані свідчать про гостру необхідність ретельної всебічної оцінки можливих біологічних ефектів електромагнітного випромінювання, а також профілактики ймовірних негативних впливів на здоров'я людини.

Мета: удосконалення методiв профілактики захворювань тканин порожнини рота в осіб, які зазнають впливу електромагнітного випромінювання.

Матеріали і методи. В ході дослідження було обстежено 65 робітників безпосередньо зайнятих на виробництві в пресово-зварювальному цеху Харківського тракторного заводу, які піддавалися впливу низькочастотного електромагнітного випромінювання. 

Контрольну групу склали 46 практично здорових людей науково-технічних робітників, які не мали прямого впливу електромагнітного випромінювання.

Результати. Особам основної групи, після проведення базового комплексного лікування був запропонований розроблений профілактичний комплекс для використання в домашніх умовах. 

Під час проведення комплексної терапії у пацієнтів зникали кровоточивість, болючість та неприємні відчуття у яснах. Проба Шиллера-Писарєва ставала слабо-позитивною у межах окремих ясенних сосочків, а до кінця профілактичного курсу не давала забарвлення.
ПОРІВНЯЛЬНА МОРФОЛОГІЯ ПРЯМОЇ КИШКИ ЛЮДИНИ ТА СВИНІ У НОРМІ
Authors: Талько В. І. , Керечанин І. В. , Плахотний Р. О.
Published: April 2020

Резюме. Знання структурної організації прямої кишки є фундаментом для розуміння етіології, клініки захворювання, техніки проведення діагностичних маніпуляцій, вибору методу лікування, у тому числі оперативного втручання.

У статті проведена ревізія попередніх та сучасних наукових робіт, що містять історію терміну «пряма кишка», опис топографії прямої кишки людини, вікові та гендерні особливості її будови і меж; визначені структурні елементи, що забезпечують нормальний пасаж вмісту; описана теорія акту дефекації. На основі літературних даних розглянуто етіологію патологічних станів, таких як закреп, інконтиненція та енкопрез, а також непухлинних захворювань, зокрема парапроктиту.

Оприлюднені сучасні дослідження провідних медичних центрів Європи, США та Японії засвідчують успіхи у галузі вивчення ксенотрансплантації, відтворенні механізму хвороб людини на молекулярному рівні, таких як м’язова дистрофія Дюшена і муковісцидоз. Дослідження відбуваються з використанням свині в якості біомоделі, оскільки ці тварини анатомічно та фізіологічно більш схожі на людей, особливо це стосується серцево-судинної, імунної, дихальної систем, скелетних м’язів, метаболізму тощо; також свині як біологічна модель активно використовуються для розробки й апробації нових медичних технологій.

Перспективи майбутнього дослідження полягають у визначенні придатності свині як біомоделі проктологічних захворювань з подальшим використанням у клінічних експериментах задля розробки нових методів лікування патології прямої кишки у людини.
ХАРАКТЕРИСТИКА ПАЦІЄНТІВ ІЗ ГОСТРИМ КАЛЬКУЛЬОЗНИМ ХОЛЕЦИСТИТОМ НА СТАЦІОНАРНОМУ ЕТАПІ РЕАБІЛІТАЦІЇ
Authors: Голод Н. Р.
Published: April 2020

Резюме. Мета дослідження: провести характеристику пацієнтів із гострим калькульозним холециститом на стаціонарному етапі реабілітації.

Методи дослідження: синтез та аналіз фахових наукових джерел; ретроспективний аналіз 50 медичних карт пацієнтів із гострим калькульозним холециститом (ГКХ), які знаходилися на стаціонарному лікуванні у хірургічному відділенні Івано-Франківської центральної міської клінічної лікарні у 2018 році.

Висновки. Найбільше пацієнтів із ГКХ – це представники середнього віку (44-60 років). Найбільша кількість ускладнень ГКХ – це ускладнення місцевим необмеженим серозним перитонітом. Також у ранньому післяопераційному періоді найбільше було випадів загострення хронічного панкреатиту та бронхіту. У 86% пацієнтів біли супутні хронічні неінфекційні захворювання, найбільше було пацієнтів із ожирінням різного ступеню – 36%.

Встановлено пряму залежність важкості ускладнень та тривалості періоду до госпіталізації – чим він довший, тим важчі ускладнення та довший період перебування у стаціонарі. Найдовше перебували у відділення пацієнти із ГГКХ.

У багатьох пацієнтів зустрічається декілька супутніх патологій, це як правило, пацієнти із різними ступенями ожиріння, чим вища ступінь, тим більше супутніх діагнозів. Представники обох статей схильні до серцево-судинних захворювань, захворювань шлунково-кишкового тракту, але спостерігається більша кількість жінок із ожирінням і цукровим діабетом ІІ типу. Більшість чоловіків хворіють на ХОЗЛ, це очевидно, обумовлено наявністю шкідливої звички – куріння.

Проведений аналіз дає можливість обґрунтувати створення та проведення алгоритму реабілітаційних заходів, які повинні починатися під час операції, продовжуватися в ранньому післяопераційному періоді та після виписки із стаціонару.
К вопросу определения интегральных характеристик рассеяния
Authors: Гапоненко О.Н.
Published: April 2020

The questions regarding the measurements of the integral characteristics of the scattering function for the media with the strong forward scattering are considered. It is shown that in the common case the contribution of the small angles in the average scattering cosine is underestimated, whereas this contribution is important for the dominant forward scattering. The method that allows to obtain the necessary corrections for such case is proposed.
Об интерпретации спектров фотохимически индуцированного кругового дихроизма полупроводниковых нанокристаллов
Authors: Сафин Ф.М. , Маслов В.Г.
Published: April 2020

An approach to the analysis and interpretation of the spectra of photoinduced circular dichroism (PICD) of semiconductor nanocrystals, in particular quantum dots, based on their comparison with the spectra of magnetic circular dichroism (MCD), is proposed. It was shown that the MCD and PICD spectra have similar features. The values of parameters similar to the known parameters A and B of the MCD spectra characterizing the splitting and mixing of states were determined from the PICD spectra.
Температурная эволюция диэлектрического отклика alpha-лактозы моногидрата в терагерцовом диапазоне частот
Authors: Командин Г.А. , Породинков О.Е. , Ноздрин В.С. , Мусина Г.Р. , Черномырдин Н.В. , Зайцев К.И. , Спектор И.Е.
Published: April 2020

With a change in temperature, a-lactose monohydrate crystals undergo changes in the molecular structure due to dehydration and decay of intramolecular bonds. The transmission spectra of the pressed microcrystalline samples of a-lactose monohydrate were measured using terahertz pulsed spectroscopy in the temperature range of the existence of the solid phase 10 – 475 K. An analysis of the observed absorption lines using the classical oscillator model made it possible to reveal the complex temperature evolution of the eigenfreuencies of the resonances, as well as to determine the region of existence of response phase of a-lactose monohydrate. Data obtained can find practical application in various fields of terahertz optics, including pharmacology, food industry, analytical chemistry and biophotonics.
Прецизионная интерферометрия как новый метод исследования конформационного состояния белка и его взаимодействия с растворителем
Authors: Матвеева Т.М. , Саримов Р.М. , Бинги В.Н.
Published: April 2020

A new method for studying the conformational state of a protein and its interaction with a solvent has been developed. The method is based on measuring the refractive index of a protein solution using a precision laser interferometer with an accuracy of 1 • 10–7. The interferometer was calibrated based on the known temperature dependence of water refractive index and concentration dependence of the refractive index of a NaCl solution. Using an interferometer, changes in the refractive index during proteolysis (an increase of 9 ∙ 10-6 and 2.4 ∙ 10-6 in the refractive index of bovine serum albumin and egg lysozyme solutions during pepsin-catalyzed hydrolysis) and denaturation (increase in the refractive index by 4.5 ∙ 10-5 during the reaction of egg lysozyme with guanidine hydrochloride and dithiothreitol) have been first recorded. Based on direct interferometric measurements, the widespread assumption has been refuted that the refractive index of protein solutions is determined only by the concentration of the protein and its amino acid composition and does not depend on the state of protein fragmentation. The increased accuracy of the interferometer allows one to study the increment of the refractive index (dn/dc) at low concentrations of dissolved compounds (<< 1%), as well as processes leading to a change in the conformation of macromolecules in solution.
Фототермическое действие инфракрасного (808 nm) лазерного излучения и наночастиц золота в различных модификациях на S. aureus
Authors: Тучина Е.С. , Тучин В.В.
Published: April 2020

The effect of infrared laser radiation (808 nm) of different fluence rates on the bacteria Staphylococcus aureus 209 P, incubated in solutions of gold nanocubes, nanorods and on glass substrates with fixed nanodiscs, was studied. Radiation with a power density of 60 mW/cm2 in combination with nanocubes caused the death of 50% of the bacterial population after 30 min of exposure, in combination with nanostructures - 56%. An increase in the temperature of suspended matter after irradiation was found of no more than 5-6 °C. Radiation with a power density of 400 mW/cm2 caused a pronounced inhibition of the viability of bacterial cells – by 81% after 30 min. Incubation of microorganism suspensions on the surface of glass substrate containing gold nanodiscs during irradiation (808 nm, 400 mW/cm2) resulted in 99% of bacterial cell death.
Digital Peer Support Mental Health Interventions for People With a Lived Experience of a Serious Mental Illness: Systematic Review (Preprint)
Authors: Fortuna Karen L , Naslund John A , LaCroix Jessica M , Bianco Cynthia L , Brooks Jessica M , Zisman-Ilani Yaara , Muralidharan Anjana , Deegan Patricia
Published: April 2020

BACKGROUND

Peer support is recognized globally as an essential recovery service for people with mental health conditions. With the influx of digital mental health services changing the way mental health care is delivered, peer supporters are increasingly using technology to deliver peer support. In light of these technological advances, there is a need to review and synthesize the emergent evidence for peer-supported digital health interventions for adults with mental health conditions.

OBJECTIVE

The aim of this study was to identify and review the evidence of digital peer support interventions for people with a lived experience of a serious mental illness.

METHODS

This systematic review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) procedures. The PubMed, Embase, Web of Science, Cochrane Central, CINAHL, and PsycINFO databases were searched for peer-reviewed articles published between 1946 and December 2018 that examined digital peer support interventions for people with a lived experience of a serious mental illness. Additional articles were found by searching the reference lists from the 27 articles that met the inclusion criteria and a Google Scholar search in June 2019. Participants, interventions, comparisons, outcomes, and study design (PICOS) criteria were used to assess study eligibility. Two authors independently screened titles and abstracts, and reviewed all full-text articles meeting the inclusion criteria. Discrepancies were discussed and resolved. All included studies were assessed for methodological quality using the Methodological Quality Rating Scale.

RESULTS

Thirty studies (11 randomized controlled trials, 2 quasiexperimental, 15 pre-post designs, and 2 qualitative studies) were included that reported on 24 interventions. Most of the studies demonstrated feasibility, acceptability, and preliminary effectiveness of peer-to-peer networks, peer-delivered interventions supported with technology, and asynchronous and synchronous technologies.

CONCLUSIONS

Digital peer support interventions appear to be feasible and acceptable, with strong potential for clinical effectiveness. However, the field is in the early stages of development and requires well-powered efficacy and clinical effectiveness trials.

CLINICALTRIAL

PROSPERO CRD42020139037; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID= 139037
Evolution of Online Health-Related Information Seeking in France From 2010 to 2017: Results From Nationally Representative Surveys (Preprint)
Authors: Ducrot Pauline , Montagni Ilaria , Nguyen Thanh Viet , Serry Anne-Juliette , Richard Jean-Baptiste
Published: April 2020

BACKGROUND

Given the rapid ongoing progression of the internet and increase in health information available from disparate online sources, it is important to understand how these changes impact online health information-seeking behavior of the population and the way of managing one’s health.

OBJECTIVE

This paper aims at describing the evolution of internet use as a source of health information between 2010 and 2017, as well as the characteristics of online health information seekers, topics of interest, sources of information, and trust in retrieved information and potential impact on behavior.

METHODS

Data from the French nationally representative surveys Health Barometers were used (N=4141 in 2010, 4811 in 2014, and 6255 in 2017). Evolutions over time were assessed using chi-square tests. Associations with sociodemographic characteristics and health status were evaluated using logistic regression models.

RESULTS

The use of the internet as a source of health information rose between 2010 and 2014 (from 37.3% to 67.9%, P<.001) but decreased significantly in 2017 (60.3%, P<.001). Overall, the profile of health information seekers compared with nonseekers did not change over time. They were more likely to be women, to be younger, to have a higher educational level, to have a higher household income, and to be executives. Between 2014 and 2017, the proportion of those who did not pay attention to the source of information significantly increased to reach 39.7% (P<.001). In 2017 as in 2014, general health-related websites remained the first source of information (38.6%) while institutional websites were the third source (8.1%). Most information seekers trusted the information found online in 2010 (more than 80%), with a slight decrease between 2014 and 2017 (P=.048). Among individual characteristics, trust in the information was the main determinant of the way of managing one’s health (odds ratio 4.06, 95% CI 3.26-5.06).

CONCLUSIONS

After a rapid growth in the internet use for seeking health information in the 2010 to 2014 period, a decrease was recorded in 2017, in parallel with a decrease in trust in the quality and reliability of information found online. These findings underline the need for public health authorities to increase citizens’ eHealth literacy and to provide alternative trustworthy sources combining the popularity and accessibility of general health information websites.
The Developmental Changes in Cube Copying Abilities of Japanese Children with Typical Development
Authors: Gotoh Takashi , Haruhara Noriko , Ishii Rina , Mogami Asako , Matsunaga Ayumi
Published: April 2020

Purpose: The purpose of this study was to analyze the developmental changes in Necker cube copying and isometric perspective cube copying abilities of Japanese children of typical development.Methods and Results: [Study-1] A total of 40 individuals aged 5-18 years participated in Study-1. The Necker cube copying task was administered, and scores were assigned based on the method developed by Yorimitsu et al. (2013). The results showed that the scores increased significantly for children in the 8-9 years age group (p < 0.01).[Study-2] A total of 32 individuals aged 6-10 years participated in Study-2. The isometric perspective cube copying task was administered, and scores were assigned based on the method developed by Otomo (2009). The results showed that the scores increased significantly for children in the 7-8 years age group (p < 0.05).Conclusions: Japanese children of typical development were able to perform the Necker cube copying task from approximately nine years of age. The same participants were able to perform the isometric perspective cube copying task from approximately eight years of age.
A multidimensional taxonomy of developmental States
Authors: Tezanos Sergio , De la Cruz Fernando
Published: April 2020

This paper proposes a new approach to the classification of Developmental States (DS) based on their public efforts to foster human development. We conceptualize DS within a multidimensional framework that includes three main dimensions (economic, social and democratic), and run a hierarchical cluster analysis for 112 countries in order to build a multidimensional taxonomy of DS. We propose a countryclassification and characterize three country-groups with different developmental public efforts: i) the human development States; ii) the unbalanced developmental States and iii) the non-developmental States. Our multidimensional taxonomy offers a more complex understanding of the variety of public efforts devoted to promote human development, thus overcoming the restricted –economical– conception of DS, which is mainly focused to the East Asian region
Coaching Method and Performance of Nurses (Case Study at Regional Hospital of Cibinong At Bogor Regency, West Java Province)
Authors: Hartono Budi , Jakri Johanes
Published: April 2020

Nurses can use coaching as the way to empower quality of their skills to have excellent services in hospital. Coaching is a tool that can improve motivation and performance of nurses. The research is aimed to get explanation about the relation of coaching, motivation and performance at a regional hospital. Methodology of this research is correlational study with 30 nurses as respondents. Path analyses are used as statistical tools. The result of this study shows that R² is about 0.704; it means that coaching has a direct, positive and significant impact to motivation and performance of nurses. Motivation has a direct, positive and significant impact to the performance of the nurses (R-value = 0.848). Coaching has an indirect, positive and significant impact to the performance of nurse through job motivation (R-value = 0.737). Conclusions of this study is coaching can increase employee potential related to work motivation, coaching aims at increasing the potential of employees who are performance oriented. Planning, implementation and evaluation of empowerment programs with effective coaching methods can ultimately improve the quality and accountability of employee performance. Result of this research implied that the use of coaching could improve motivation and performance for nurse in the hospital.
Early Breastfeeding Initiation in Indonesia
Authors: Lisna Aulia , Arifin Rika Yumna Afifah , Anjasmara Rizki Ari
Published: April 2020

Breastfeeding exclusive around the world given in infants only about 32,6 million from babies born 136,7 million, in developing countries only about 39 % given breastfeeding by his mother, it was far from the target who want to 80 %.The purpose of this article is to know implementation and nursing (early breastfeeding initiation - IMD) breastfeeding exclusive in the world and the Indonesian descriptive study is based on the implementation of showing limited the exclusive breastfeeding in the world and in Indonesia. Facilitate of IMD still less than optimal.
The Role of Parents in Educational and Character of Children
Authors: Kholifah Deas Nurul , Apriani Tania , Larasati Sekar
Published: April 2020

N/A
Limits of Phenomenology of Religion
Authors: Grimmich Šimon
Published: April 2020

The author investigates whether Anthony J. Steinbock, in his book Phenomenology and Mysticism: The Verticality of Religious Experience, succeeds in overcoming the difficulties and objections which the phenomenology of religion traditionally comes up against. Among these are, most importantly, the problem of going beyond immanence and the question of whether the investigation of religion from a phenomenological point of view is in fact possible.
The Trapped Female Breaking Loose: William Faulkner's "Elly" (1934)
Authors: Skei Hans H.
Published: April 2020

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The Status of Waldo Frank in American Letters
Authors: Nilsen Helge Normann
Published: April 2020

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10 años de hospitalización a domicilio en el entorno de un hospital comarcal
Authors: Diaz Gegundez Mercedes , Gomez de Argila Isabel , Ferrer Cobo Ester , Castelar Delgado Esperanza
Published: April 2020

Introducción: La Hospitalización a Domicilio (HAD) se inició en nuestra zona a finales de 2007, actualmente consta de 3 unidades, 30 camas y tiene una cobertura territorial del 80%. La modalidad de ingreso es mixto, evitación de ingreso y alta precoz. Objetivo: analizar los resultados de HAD en los últimos 10 años en cuanto a eficacia y eficiencia.Método: Análisis retrospectivo de los pacientes ingresados en HAD (enero 2009-Diciembre 2018) para definir tipología de paciente y procedencia, evaluar indicadores de estancia media, retorno al hospital, reingreso a los 30 días, mortalidad y coste comparado con hospitalización convencional.Resultados: Se han realizado 6.033 altas. El 86% de los pacientes ingresaron por un proceso médico con predominio de las enfermedades del aparato respiratorio (43,7%). La modalidad de evitación de ingreso supuso el 79% de los ingresos en HAD. La estancia media en HAD fue de 7,1 días y el retorno al hospital por complicaciones del 4,1%. La mortalidad fue del 2,3% y los reingresos por cualquier motivo en los 30 días siguientes al alta de HAD del 12,2%, ambos inferiores a los resultados de las unidades de hospitalización de Medicina Interna. La gravedad según el sistema de clasificación APR-DRG de los pacientes ingresados en HAD fue significativamente superior a la encontrada en la Unidad de Corta Estancia pero menor que en las unidades de hospitalización de Medicina Interna, tal como era de esperar. El coste de estructura por día de estancia en HAD fue, aproximadamente, 3 veces inferior al de hospitalización convencionalConclusiones: HAD ha sido una alternativa útil a la hospitalización convencional, principalmente para patología médica de pacientes que precisando ingreso, no necesitaban toda la infraestructura hospitalaria.