bluuebunny/crossref_metadata_2025 huggingface dataset:
SYNTHESIS OF MAGNETICALLY SEPARATED BIOCATALYTIC SYSTEMS
Authors: Grebennikova Olga , Sulman Aloeksandrina , Matveeva Valentina
Published: February 2023

The use of magnetic nanoparticles in biocatalysis, due to their unique properties, such as controlled particle size, large surface area, and ease of separating them and the reaction mixture by applying an external magnetic field, makes it possible to reuse enzymes immobilized on magnetic nanoparticles for catalytic processes. In this work, horseradish root peroxidase was immobilized on Fe3O4 magnetic nanoparticles. The carrier surface was modified and activated before enzyme immobilization using 3- aminopropyltriethoxysilane and glutaraldehyde. Testing of biocatalytic systems was carried out in the oxidation reaction of 2,2'-azino-bis-(3-ethylbenzthiozolin-6-sulfonic acid) diammonium salt with hydrogen peroxide. The immobilized enzyme showed high efficiency and stability compared to the native enzyme. Also, in the work, the joint immobilization of peroxidase and glucose oxidase on magnetically attached carriers was studied. Enzymes were immobilized on Fe3O4 magnetic nanoparticles and SiO2. Optimal conditions (temperature, pH) were selected for all biocatalytic systems.
THE ROLE OF BACTERIORHODOPSIN IN LIGHT HARVESTING AND ATP PRODUCTION BY HALOBACTERIUM SALINARUM CELLS
Authors: Drochioiu Gabi
Published: February 2023

Halobacterium salinarum is an extremely halophilic marine Gram-negative obligate aerobic archaeon. Despite its name, this is not a bacterium, but rather a member of the domain Archaea, which lives in hypersaline lakes. Bacteriorhodopsin (BRh) is the red retinal-containing protein found in the cell membranes of H. salinarum and is considered a light-activated proton pump that transports protons across the plasma membrane. Bacteriorhodopsin photointermediates have been defined in kinetic and spectroscopic terms as BR568, K590, L550, M412, N560, and O640. We have previously shown, using the Forster cycle for BRh that its acidity increases greatly on illumination. Therefore, protons released upon illumination of the L550 intermediate with 412 nm light may not play an essential role in ATP production. Instead, the light-induced excitation energy, which represents the energy difference between the L550 and M412 states, can be used to extract an ATP molecule attached to ATP synthase. Thus, we have shown that this amount of energy corresponds to a near-infrared vibration, which is sufficient for ATP production and provides the most feasible molecular mechanism for this phenomenon. Here, we provide new evidence that protons are released due to BRh excitation, unrelated to ATP synthesis, being only a secondary phenomenon. In addition, once released from H. salinarum cells, protons should return back into the cells via ATP-synthase molecules to produce ATP. This is not possible at pH > 7.0, such as pH 9.5. However, the stability of M intermediates and ATP formation appear to be increased at higher pH values. Indeed, a spectral shift of 138 nm may be associated with an energy amount of about 17 kcal mol-1, which is enough energy to release a mole of ATP from ATP-synthase. In general, light excitation of fluorescent molecules is a phenomenon that induces a strong increase in their acidity. Recent data suggest that the chemiosmotic hypothesis put forward by Peter Mitchell to explain ATP formation in living cells is not correct, at least in terms of explaining light-induced ATP production in H. salinarum cells.
PROCEDURE AND RESULTS OF MEASURING THE WIDTH OF PEDESTRIAN ROADS IN SMALL TOWNS
Authors: Kramarova Zuzana , Rezacova Kristyna , Pavlista Martin
Published: February 2023

Pedestrian roads in the Czech Republic are currently designed following the valid Czech technical standard CSN 73 6110 entitled "Design of local roads". According to this standard, the width of sidewalks is designed according to the speed, intensity, and current density of pedestrians, ie in a very similar way to the design of roads for motor vehicles. However, the vast majority of small towns do not have processed field measurements that determine the relevant values, so they only propose the minimum width of sidewalks required by the standard (1.5 m), which is inappropriate in terms of the quality of public space. Therefore, the project SVV202104 entitled "Requirements and categorization of the width of pedestrian roads in the context of the type of public space" was created, which aims to develop a simpler methodology for determining the minimum width of sidewalks in different types of public space. The paper builds on two already published texts. The first one dealt with the survey of the legislative framework and available approaches of individual authors, which solve the requirements for the width of pedestrian roads, and the second with the categorization of the public space of small towns. This paper describes the course of field measurements in nine small towns, which was carried out within SVV202104. It also deals with the evaluation of these measurements.
Stoma close to the abdominal wound – A real technical problem: A description of a novel care strategy
Authors: Borejsza-Wysocki Maciej , Bobkiewicz Adam , Ledwosiński Witold , Szmyt Krzysztof , Banasiewicz Tomasz , Krokowicz Łukasz
Published: February 2023

Introduction: In some clinical scenarios, a stoma site may be located close to the edge of the abdominal wound, impeding optimal wound management and stoma care. We present a novel strategy of using NPWT to manage both abdominal wound and stoma simultaneously.

Material and methods: A retrospective analysis of 17 patients treated with a novel wound care strategy was conducted. The application of NPWT within the wound bed, around the stoma site, and the skin between helps in 1) separating the wound from the stoma site, 2) maintaining an optimal environment for wound healing, 3) protecting the peristomal skin, and 4) facilitating the application of ostomy appliances.

Results: The study group was comprised of 12 women (70.6%) and 5 men (29.4%) with a mean age of 49.1 18.4 years. The most common underlying pathology was Crohn’s disease (n = 5; 29.4%). After the implementation of NPWT, patients underwent from 1 to 13 surgeries. Thirteen patients (76.5%) required admission to the intensive care unit. The mean time of hospital stay was 65.3 28.6 days (range: 36–134). The mean number of NPWT sessions was 10.8 5.2 (range: 5–24) per patient. The negative pressure ranged from –80 to –125 mmHg. Progress in wound healing was achieved in all patients, resulting in granulated tissue formation, minimal wound retraction, and thus reduction of the wound area. As a result of NPWT, the wounds were granulated entirely, tertiary intension closure was achieved, or patients were qualified for reconstructive surgery.

Discussion: NPWT is a safe and useful therapy for complicated abdominal wounds with the presence of a stoma close to the wound’s edge. A novel care strategy allows for simultaneous technical opportunity to separate the stoma from the wound bed and facilitate wound healing.
In this study, we described a novel combined technique for complicated abdominal wounds with a stoma close to the wound’s margins. We emphasize some tricks and tips that might be important from a practical point of view to optimize holistic management.
Polythene mulching and fertigation in peanut (Arachis hypogaea): Effect on crop productivity, quality, water productivity and economic profitability
Authors: JAIN N K , JAT RAM A , YADAV R S , BHADURI DEBARATI , MEENA H N
Published: February 2023

Enhancing crop productivity, profitability and saving of precious natural resources (soil and water), is a matter of prime concern. With this backdrop, a field experiment was conducted during kharif 2011-2013 at Junagadh (Gujarat) with mulching and fertigation treatments in peanut (Arachis hypogaea L.) in split plot design with three replications. Polythene mulching significantly enhanced pod, haulm, kernel and oil yields over no mulch. Moreover, it also ensured higher partial factor productivity, water productivity, net return, soil moisture content (at flowering, pegging, and pod formation stages of peanut), and N, P and K uptake over no mulch. Amongst the fertigation treatments, F2 was found better in improving pod, haulm, kernel and oil yields, and P uptake over F1. However, maximum partial factor productivity was recorded under F1 while water productivity, net return, soil moisture content, and N and K uptake under F4. Alkaline phosphatase activity was better sustained in F3 over F1 and F2. Soil N, P and K status improved under mulching and fertigation treatments. Our study revealed the possibility of adoption of mulch and fertigation at farmersâ€™ fields implying judicious use of water and nutrients assuring a good yield and net profit.
Primera documentación de reproducción exitosa de Águila Coronada o Águila del Chaco (Buteogallus coronatus) en la Provincia de Santa Fe, Argentina
Authors: Merlino Víctor , Gallego Diego
Published: February 2023

El Águila Coronada o Águila del Chaco (Buteogallus coronatus) es una especie de ave rapaz del sur de Sudamérica. Sus poblaciones se encuentran amenazadas, entre otros factores, por la destrucción del hábitat, la persecución directa, la electrocución en tendidos eléctricos y el ahogamiento en reservorios de agua. En los últimos años, los registros de territorios, nidos y reproducciones exitosas de la especie en Argentina se han concentrado al sur de su límite de distribución (oeste de La Pampa y sur de Mendoza). Sin embargo, en la provincia de Santa Fe, considerada clave para la conservación de esta especie, nunca se registró una reproducción exitosa. En esta publicación damos cuenta del descubrimiento y monitoreo de un nido activo de Águila Coronada en la provincia de Santa Fe que resultó exitoso. Este hallazgo pone de manifiesto la necesidad de establecer un monitoreo a largo plazo de las poblaciones de la especie en esta provincia.
Truth effects in the us justification of the wars on drugs and terror
Authors: Pieper Elza Carolina Beckman
Published: February 2023

In this communication, we intend to discuss aspects of the North American interventionist policy. Based on authors such as Frédéric Gros, Michel Foucault, and Tzvetan Todorov, in particular, through the mobilization of concepts such as "power", "knowledge", "territory" and "truth", the statement is discussed, exploring the construction of the justification of the war, the spectacularization of history and politics (GREGOLIN, 2003), the politicization of the law, the foreigner as a synonym of barbarism. Having presented the research problem, a discussion is made on the relationship between discourse, politics, war, and truth. The objective is to show how the United States of America treats other nations, ranking places in terms of values in such a way that it separates territories between civilized and barbarians, leaving the solution to problems of violence to the exogenous subject. In other words, while Americans are civilized and competent, bearers of dignified values, such as honesty and civilization, foreigners are barbaric and incapable, thus naturalizing crime and savagery. The former has the mission of rescuing the latter from their anomalous condition. Scholars such as Todorov (2003, 2010), Gros (2009), Rodrigues (2004, 2012), and Amaral (2010) support our understanding of the "dangers" spread by the media about controversial regions due to conflicts between "savages" and "civilized", war on terror, narco-terrorism. We live in situations that we cannot call a state of authentic war or a state of pure peace, but a state of violence (GROS, 2009). The global political climate is one of latent conflict with occasional interventions in the name of planetary security. According to Herz (apud AMARAL, p.17), since the end of the Cold War, US security policy for Latin America, especially for the Brazil/Argentina/Paraguay triple border, has been based on the rhetoric of war and militarization of politics. The analysis of the conditions for the production of knowledge in its relations with the powers that be allows an enunciative analysis in the terms defended by Foucault, that is, historical (2009, p. 124).
Geogebra software in basics of flat geometry: a teaching methodology for the major fundamental
Authors: Macedo Felipe , Costa Manuel de Jesus dos Santos , Lima Rômulo Correa , Lobato Júnior José Maria dos Santos , Chaves Rodrigo Ronald Carvalho , Cordeiro Sebastião Martins Siqueira , Chaves Neto Antonio Maia de Jesus , Medeiros Robson André Barata de , Costa José Francisco da Silva
Published: February 2023

The present study has as its main focus to address how the use of the GeoGebra software can positively impact the learning of basic concepts of plane geometry for the greater fundamental. It seeks to analyze which of the main positive impacts of the use of the GeoGebra software on basic concepts of plane geometry: a teaching methodology for the major fundamental. This is, addressing the GeoGebra operational system in basic concepts of plane geometry: a teaching methodology for the fundamental one that is more justified - there is a need to show how technology can facilitate the geometric teaching-learning process, and that becomes of notorious importance The utility in the training of the student, the way in which this computational can be used for teaching of basic notions of plane geometry. The present study consists of a research of a descriptive nature, with results treated in a qualitative manner, from the collection of data from secondary sources, including a bibliographic review. As sources of search, books, articles and sites will be used that say about the subject worked, together with authors who treat the importance of reconciling technology and education in the contemporary world. As a result of the survey of information throughout the research and the analysis of the information, it was possible to conclude that the applications of plane geometry together with the GeoGebra software, published positively by a series of authors who are referenced in this research, by country, or by the program provided The user will have a visual experience of two theoretical concepts seen in class, and these are two important factors for geometry teaching. Being likewise, the construction of flat geometric figures through the GeoGebra program shows itself to be an indispensable tool for the fundamental teaching of today, in order to form a student more prepared for future series.
Efficacy of Vaccination against Eimeria spp. in poultry
Authors: Ferreira Gilberto Chiantelli , Cassiano Rodrigo Pereira , Beretta Bruna Matarucco Sampaio , Fernandes Rodrigo Antonio , Sa Katia Denise
Published: February 2023

Eimeriosis represents a considerable challenge faced by the global poultry industry due to the damage it causes. Three species of Eimeria in chickens, in this case, E. acervulina, E.max and E. tenella have the potential to affect the occurrence and extent of resistance to anticoccidial drugs and future vaccines. Thus, it is clear that vaccination against avian eimeriosis has an important role in maintaining biosafety and productivity in poultry breeding, since in addition to providing the immunization of animals, it helps in increasing the therapeutic efficiency of anticoccidial drugs. In this study, we investigated the effectiveness of vaccination against eimeriosis in broiler birds. In total, 589 articles were compiled in research databases and scientific publications. As a filter to avoid duplication between works, 62 articles were obtained. Of these, in only five did we observe a very high degree of recommendation for the use of DNA vaccination, which was considered more effective in preventing eimeriosis, with a lower degree of side effects.
Structural instability mechanisms on bridges neoprene bearings
Authors: Mendes Luiz Carlos , Braga Gustavo Coquet
Published: February 2023

Bearings are subjected to several structural instability mechanisms due to their loads. Several mechanisms involving buckling are to be analyzed in this article, like strain limit, sliding limit, tensile in steel sheet, rotation limit verification, curvature instability and friction instability to different kinds of loads. Finite Element Method and Symbolic Algebraic Computation were employed in order to analyze behavior in several bearings sections in compliance with European Codes.
Sustainability indicators in municipal waste management in the municipality of Salvaterra (Ilha do Marajó-Pará)
Authors: Ogorodnik Maria Eduarda Assumption , Borges Heloiza Santos , Castro Anne Sanches de , Nascimento Deyved Leonam Guimarães do , Dourado Junior Octavio Cascaes , Chaves Andrea Fagundes Ferreira
Published: February 2023

The municipality of Salvaterra is located on Marajó Island and is one of the Brazilian municipalities where the final disposal of solid waste still occurs incorrectly. In this sense, the present work aimed to analyze the current scenario of solid waste management in the municipality of Salvaterra/PA through the system of sustainability indicators PEIR (Pressure-State-Impact-Response). The results show thatthe waste generated in the municipality is disposed of in a dump located near the city and that the health service waste, produced in hospitals, is burned in the open air in this same dump. There is no type of solid waste management, waterproofing of soil or treatment of gases generated by the decomposition of the city's waste, which further aggravates the situation because the water resources and soil can be contaminated by slurry, the population is vulnerable to the contagion of vector-borne diseases and the burning of health service waste contributes to air pollution and can also cause respiratory diseases. Thus, it is noted that the system of sustainability indicators PEIR proved to be an effective tool to perform the first data collection and municipal diagnosis on the reality of waste in Salvaterra, thus being a starting point that can support actions, stimulate and direct new studies and complement the construction of the municipal waste management plan.
Infección por virus de papiloma humano en mujeres atendidas en un centro de atención primaria de salud en Honduras, 2017
Authors: Avilez-Soto Carlos , Rosales-Ordoñez Carlos , Soto-Bonilla Carmen , Ordoñez-Elvir Gladys
Published: February 2023

Objetivo: Mediante la prueba CareVPH (prueba para detección del ADN de VPH oncogénico) determinar la frecuencia de infección por VPH oncogénico en mujeres de 30-64 años que acuden al Centro Integral de Salud San Benito de Honduras, entre enero y diciembre del año 2017. Metodología: Estudio no experimental, descriptivo, longitudinal, retrospectivo realizado en el Centro Integral de Salud San Benito, con una población de 2,249 mujeres en edades entre los 30 y 64 años. Se aplicó estadística descriptiva y se utilizó el programa EPI INFO V7 para el análisis de datos. Resultados: Se confirmaron 332 casos positivos (14.76%) del total de las mujeres en el estudio. La mayoría de los casos positivos de VPH fueron detectados por el método de muestra autoaplicada 2120 (94.28%). El grupo etario con más casos positivos de VPH es el de 30 a 39 años, con 184 casos (55.42%), seguido del grupo de 40 a 49 años con 83 casos (25%). Conclusiones: El estudio reveló una alta prevalencia de infección por VPH oncogénico en mujeres de 30-64 años en el Centro Integral de Salud San Benito, con una tasa de infección del 14.76%. El grupo etario con el mayor número de casos positivos fue el de 30 a 39 años. La prueba CareVPH resultó ser una herramienta eficaz para la detección de VPH oncogénico en mujeres de 30-64 años.
trastorno dismórfico corporal: una patología subdiagnosticada con impacto clínico
Authors: Hernández-Chavarría Vivian , Rojas-Mendoza Karol , Min-Kim Hery , Yglesias-Dimadi Ioanna , Castro-Torres Grettel
Published: February 2023

Este artículo se enfoca en el trastorno dismórfico corporal, su prevalencia, diagnóstico y tratamiento, así como en el grado de introspección y la eventual presencia de dismorfia muscular. Además, aborda el subdiagnóstico de esta patología y sus implicaciones clínicas para el paciente y el médico tratante.
epilepsia y factores de riesgo: una revisión narrativa
Authors: Sequeira-Quesada Carlos , Delgado-Gómez Diego , Céspedes-Valverde María , Chaves-Jimenez Marianela
Published: February 2023

La epilepsia es un trastorno neurológico común a nivel mundial que afecta a más de 50 millones de personas, desde niños hasta adultos de edad avanzada. Existen diferentes factores de riesgo que pueden contribuir al desarrollo de la epilepsia, como factores ambientales, factores orgánicos, factores asociados al recién nacido o a la mujer gestante. Por tanto, es necesario reconocer estos factores para proporcionar una atención integral adecuada al paciente, con diagnóstico y tratamiento adecuados. Además, al identificar los factores modificables, se pueden tomar medidas para prevenir la aparición de epilepsia en las personas.
Machine learning approach to predict delay in smart infusion pump
Authors: Venkata Alamelu Jayakumar , Mythili Asaithambi
Published: February 2023

Wireless smart infusion pumps are currently under development. It is critical to ensure that the patient receives the correct drug concentration. Practically, the performance of the pump has relied on the minimum startup delay. The minimization of the startup delay is prominent in open-type infusion pumps and rarely in closed types. The emphasis on reducing startup delay puts practitioners and caregivers at ease while ensuring patient safety. The startup delay of the infusion pump is based on the flow rate and the lag time. The prediction of the flow rate and lag time for an infusion pump is necessitated to ensure a safe drug dosage for the patient. Currently, machine learning methods and computational methods to predict the desired parameter are widely used in healthcare applications and medical device performance. The reduction of start-up delay can be achieved by predicting its associated parameters lag time and flow rate. The flow rate is dependent on the speed of the infusion pump, which has to be calculated based on the number of gears and revolutions. The speed of the pump has to be predicted for accurate flow delivery. Our present research attempts to predict the lag time of an infusion pump using different kernel functions of support vector regression (SVR). The performance of the SVR for each kernel function is compared with R2, RMSE, MAE, and prediction accuracy. The prediction accuracy of 99,7 % has been obtained in optimized SVM
Pendidikan Islam Masa Pra Kemerdekaan; Telaah Kebijakan Pendidikan Islam Masa Penjajahan
Authors: Iskandar Khusnan , Ansori Ahmad Syahrul
Published: February 2023

This article conveys about the dynamics of Islamic education in the Pre-Independence era, Islamic boarding school education as native Indonesian education, as well as the development of Indonesian Islamic education during the colonial period, both the Dutch and Japanese colonial periods. The influence of colonialism cannot be denied in the current Islamic education system. This study uses a qualitative method which is a literature review by analyzing related sources. The development of Indonesian education is quite dynamic, greatly influencing various directions of the Indonesian Nation. The importance of exploring the noble values of national identity to improve things that need to be fixed in the field of education. It can be concluded that we are too hegemony with the policies of the colonialists, unfortunately these influences are still embedded today in education in general.
Comparing the Effectiveness of Nuclear and Air-independent propulsion Submarine Fleets
Authors: Lazzarotti Diniz Costa Eugenio Pacelli , Proença Jr. Domício
Published: February 2023

This article proposes a methodology that enables one who has actual cost figures to perform the calculations for benefit-to-cost, strictly from the tactical and logistical standpoints, on the performance equivalence not of nuclear vs. air-independent-propulsion (AIP) submarines, but of nuclear v. AIP submarine fleets. With that in hand, it becomes possible for whomever might have sounder figures than what we could find about the complete life-cycle cost of either alternative to figure out, given our results about the benefit assessment, what would be the result of a benefit-to- cost analysis. We didn't perform the latter, due to uncertainty about the methodology by which the public available cost estimates were calculated. By providing a method for benefit calculation of the military worth of alternatives to support an assessment of the SSN/SSP fleet alternatives, we hope to have provided a sounder point of departure for debate, both in general terms, a method, and for the Brazilian case in particular, an application.
Caracterização de Falhas Relacionadas a Aplicações de Live Streaming na Internet
Authors: Jansch-Pôrto Ingrid
Published: February 2023

Sistemas de difusão de conteúdos em tempo real – live streaming – construídos sobre a Internet, e especialmente aqueles que exploram arquiteturas peer-to peer, estão sujeitos a falhas naturais e humanas. Para que as aplicações não só sobrevivam, mas apresentem características atrativas aos (muitos) milhares de usuários, diversos mecanismos precisam ser usados como suporte. Este artigo visa apresentar os principais tipos de falhas que afetam estes sistemas e bem como tecer comentários sobre dificuldades relacionadas ao seu tratamento, além de informações sobre a modelagem de falhas. O artigo não pretende oferecer soluções, mas servir como um alerta a pesquisadores iniciantes na área.
Abordagem para Desviar Pacotes na Presença de Falha em Backbones IP com OSPF
Authors: Barreto Fernando , Wille Emilio C. G. , Nacamura Júnior Luiz
Published: February 2023

Os backbones IP utilizam protocolos de roteamento do tipo estado do enlace para definir as rotas corretamente. Em situações de mudança na topologia, como uma falha, esses protocolos necessitam de um tempo para reagir e encontrar novas rotas. Durante esse tempo, as rotas ficam instáveis com alta taxa de pacotes perdidos e queda na confiabilidade do backbone. Esse trabalho propõe uma abordagem pró-ativa para auxiliar os protocolos de roteamento a reduzir a taxa de pacotes perdidos durante esse período. Essa abordagem é avaliada em representações de topologias artificiais e reais, e também em simulação para analisar a redução de pacotes perdidos, demonstrando resultados bastante satisfatórios.
Cannabinoids: new friends in bone fracture and in joint disease prevention?
Authors: Palmini Gaia , Marini Francesca , Giusti Francesca , Donati Simone , Aurilia Cinzia , Falsetti Irene , Zonefrati Roberto , Galli Gianna , Iantomasi Teresa , Brandi Maria Luisa
Published: February 2023

n recent years the endocannabinoid system (ES) has been recognized to play an important role in the regulation of several physiological processes, including pain perception, appetite control, and motor function development. This system has recently been recognized to be present in bone and joint tissues, playing a role in the regulation of bone and joint physiology. The ES seems to play its role mainly by acting on its receptors and thanks to the demonstrated ability of bone cells to synthesize the principal endocannabinoids (i.e., anandamide and 2-arachidonoylglycerol), which can act on bone remodeling and metabolism. Cannabinoids have also been shown to be produced within synovial tissues, and recent studies have shown that cannabinoid receptor ligands are effective in the treatment of inflammatory arthritis. In recent years synthetic endocannabinoid-like compounds and phytocannabinoids, which are the principal components of Cannabis sativa, have also started to be studied as molecules that could play a role not only in bone physiology, but also in the pathogenesis of osteoporosis, the most common bone disease, and in the inflammatory processes underlying osteoarthritis. Accumulating evidence that cannabinoids and their receptors play an important role in bone metabolism and in the regulation of the immune response is now starting to show us the true future therapeutic potential of cannabinoids, and of the phytocannabinoids contained in Cannabis sativa, in the treatment of bone loss and joint diseases. Here we summarize the role of the cannabinoids and their receptors in bone metabolism, osteoporosis, and joint disease.
Diagnosis of Amyloidosis: Clinicopathological Advances and Challenges
Authors: Nachiappa Ganesh Rajesh , Truong Luan
Published: February 2023

Amyloidosis is a systemic disease with different subtypes of misfolded, insoluble proteins, which are deposited in viscera and thereby cause damage to the affected organs. Its clinical manifestations are highly variable depending on the organs and tissue affected and often require a high degree of clinical suspicion to achieve correct diagnosis. Development of proteomic tools, radioisotope scintigraphy, immunologic antibody targets by immunohistochemistry, immunofluorescence and microscopic techniques have improved the sensitivity of accurate detection of specific subtypes of amyloid proteins. Newer therapeutic targets have been developed to arrest or suppress the specific types of amyloid proteins, giving rise to the possibility of targeted therapy with better quality of life and improved survival benefits for patients. AL, ATTR, AA and ALECT2 are the major subtypes of amyloidosis and kidney, heart, soft tissue, and peripheral nerves are the most affected viscera. The key to achieving success in better quality of life and overall survival in patients, is in early diagnosis and accurate subtyping of amyloidosis.
Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial
Authors: Shahrokhzadeh Negin , Khorramnia Saeed , Jafari Amin , Ahmadinia Hassan
Published: February 2023

Background: Postoperative pain management is one of the major challenges of surgeons and anesthesiologists. Objectives: This study aimed to determine the efficacy of topical ketorolac in post-hemorrhoidectomy pain management. Methods: This clinical trial was conducted on 84 candidates for hemorrhoidectomy (grade-II hemorrhoids) who visited Ali ibn Abi-Talib hospital of Rafsanjan, Kerman, Iran (2020 - 2021). The participants were selected through convenience sampling and randomly assigned to three groups of 28. The subjects were treated in topical (4 mL 0.5% Marcaine + 1 mL ketorolac at the surgical site), intramuscular (4 mL 0.5% Marcaine at the surgical site + 1 mL ketorolac intramuscularly), and control (4 mL 0.5% Marcaine at the surgical site) groups. Pain intensity was measured using the Numerical Pain Rating Scale 1, 6, 12, and 24 hours after surgery. The obtained data were analyzed using two-way repeated measures analysis of variance. Results: Female and male patients constituted 46.4% and 53.6% of the participants, respectively. The mean pain intensity was significantly lower in the topical group than in intramuscular and control treatments in all four stages of pain assessment (P < 0.001). Some participants were treated with pethidine due to high pain intensity. However, the mean pain intensity gradually reduced over time in all three groups. Conclusions: Study findings suggested that the topical administration of ketorolac and Marcaine was more effective than Marcaine used alone for relieving pain in patients undergoing hemorrhoidectomy.
Promoting conceptual understanding of differential equations through inqiury tasks
Authors: Rogovchenko Yuriy , Rogovchenko Svitlana
Published: February 2023

Courses in Differential Equations (DEs) have been an important part of engineering education for decades. However, students experience difficulties with the understanding of main concepts including differential equation itself and diverse types of solutions (general, particular, stationary). In this paper, we discuss how the work on non-routine problems on the Existence and Uniqueness Theorems (EUTs) helps students to make sense of DEs and their solutions thus contributing to the development of advanced mathematical thinking.
ҒЫЛЫМҒА ИНВЕСТИЦИЯНЫҢ ДЕҢГЕЙГЕ ӘСЕРІ МӘСЕЛЕЛЕРІ ЕЛДІҢ ДАМУЫ
Authors: БАЯХМЕТОВА А.Т. , САРЖАНОВ Т.С. , МУСАЕВА Г.С.
Published: February 2023

Низкое качество публикации статей казахстанских ученых заключается, прежде всего, низкой заинтересованностью исследователей в проведении качественных научных исследований. Связан данный факт с необходимостью формального их проведения. Почему имеет место быть этому? Ответ кроется в процессе финансирования проектов. Тематика некоторых исследований, получивших финансирование, вызывает сомнения в способности, генерировать современные научные знания, которые могут трансформировать представления о том, каким образом необходимо управлять обществом, экономикой и природными ресурсами.

Қазақстандық ғалымдардың мақалаларын жариялау сапасының төмендігі, ең алдымен, зерттеушілердің сапалы ғылыми зерттеулер жүргізуге қызығушылығының төмендігі болып табылады. Бұл факт оларды ресми түрде жүргізу қажеттілігімен байланысты. Неліктен бұл орын алады? Жауап жобаларды қаржыландыру процесінде жатыр. Қаржыландыруды алған кейбір зерттеулердің тақырыбы қоғамды, экономиканы және табиғи ресурстарды қалай басқару керектігі туралы идеяларды өзгерте алатын заманауи ғылыми білімді қалыптастыру қабілетіне күмән тудырады.

The poor quality of the publication of articles by Kazakhstani scientists is, first of all, the low interest of researchers in conducting high-quality scientific research. This fact is connected with the need for their formal implementation. Why is this the case? The answer lies in the process of financing projects. The subject matter of some of the studies that have received funding raises doubts about the ability to generate modern scientific knowledge that can transform ideas about how to manage society, the economy and natural resources.
ТӨМЕНГІ ЖҮК ТҮСІРЕТІН АВТОСАМОСВАЛДЫ ҚОЛДАНА ОТЫРЫП, АСФАЛЬТБЕТОН ЖАБЫНДАРЫН САЛУДЫҢ ПЕРСПЕКТИВАЛЫҚ ТЕХНОЛОГИЯЛАРЫ
Authors: КАЛИЕВ Е.Б. , КОЗБАГАРОВ Р.А. , БАЗАРГАЛИЕВ А.А. , БЕКЕТОВ Т.С. , КАМБАРОВА З.Н.
Published: February 2023

В работе приведен процесс взаимодействия автосамосвала с донной разгрузкой с асфальтобетонной смесью. Рассмотрен процесс взаимодействия и обоснован выбор математической модели взаимодействия автосамосвала – перегружателя – асфальтоукладчика, определена степень влияния машин на производительность комплекса и осуществлен выбор режимных параметров технологических машин.

Жұмыста автосамосвалдың асфальтбетон қоспасымен түбін түсірумен өзара әрекеттесу процесі келтірілген. Өзара әрекеттесу процесі қарастырылып, автосамосвал – жүк тиегіш – төсегіш өзара әрекеттесуінің математикалық моделін таңдау негізделді, машиналардың кешеннің өндірісіне әсер ету дәрежесі анықталды және технологиялық машиналардың режимдік параметрлерін таңдау жүзеге асырылды.

The paper describes the process of interaction of a dump truck with bottom unloading with asphalt concrete mixture. The interaction process is considered and the choice of a mathematical model of interaction of a dump truck – loader – paver is justified, the degree of influence of machines on the performance of the complex is determined and the choice of operating parameters of technological machines is made.
ТАЛШЫҚТЫ-ОПТИКАЛЫҚ КАБЕЛЬДЕРДІҢ МЕХАНИКАЛЫҚ СИПАТТАМАЛАРЫ МЕН ПАЙДАЛАНУ СЕНІМДІЛІГІН ЗЕРТТЕУ
Authors: КЕМЕЛЬБЕКОВ Б.Ж. , ОМАРОВА Б.А. , ОМАРОВА Г.А.
Published: February 2023

В работе представлен обзор методов измерений волоконно-оптических линий связи, а также анализ измерительных приборов, которые используются в эксплуатации ВОЛС. Рассматриваются в основном характеристики измерительных приборов, которые используются при измерениях параметров оптоволокна. Проводится экспериментальное исследование, где по результатам эксперимента будет известно какими недостатками обладают измерительные приборы, которые участвуют в измерении затухания оптического сигнала, работающего в пятом окне прозрачности.

Жұмыста талшықты-оптикалық байланыс желілерін өлшеу әдістеріне шолу, сондай-ақ ТОБЖ жұмысында қолданылатын өлшеу құралдарын талдау ұсынылған. Негізінен талшық параметрлерін өлшеу кезінде қолданылатын өлшеу құралдарының сипаттамалары қарастырылады. Эксперименттік зерттеу жүргізіледі, онда эксперимент нәтижелері бойынша мөлдірліктің бесінші терезесінде жұмыс істейтін оптикалық сигналдың әлсіреуін өлшеуге қатысатын өлшеу құралдарының қандай кемшіліктері бар екендігі белгілі болады.

The paper presents an overview of measurement methods of fiber-optic communication lines, as well as an analysis of measuring devices that are used in the operation of fiber-optic communication lines. The characteristics of measuring devices that are used for measuring fiber parameters are mainly considered. An experimental study is being conducted, where, according to the results of the experiment, it will be known what disadvantages the measuring devices that participate in measuring the attenuation of an optical signal operating in the fifth transparency window have.
ТЕМІРБЕТОН КОНСТРУКЦИЯЛАРЫ ЭЛЕМЕНТТЕРІНІҢ БЕРІКТІГІ МЕН КӨЛДЕНЕҢ ДЕФОРМАЦИЯСЫ ТҰРҒЫСЫНАН СЕЙСМИКАЛЫҚ СИПАТТАМАЛАРДЫҢ ӘСЕРІН БАҒАЛАУ
Authors: ИБРАГИМОВ О.А. , КУРМАНОВА Ш.К. , ЛЕЩЕНКО А.
Published: February 2023

Сейсмические характеристики зданий железобетонных конструкции с элементами, поврежденными коррозией, следует оценивать количественно и непосредственно, используя коэффициент снижения конструктивных характеристик, основанный на способности к деформации, то есть способности рассеивать энергию. Это позволит точно оценить сейсмические характеристики радиоуправляемых конструкций. Основная цель исследования – предложить практическую методологию оценки сейсмических характеристик зданий железобетонных конструкции с элементами, поврежденными коррозией. Коэффициент ухудшения конструктивных характеристик, определяемый прочностно-деформационной способностью проржавевших элементов, используется для количественной и прямой оценки их сейсмических характеристик.

Коррозиядан зақымдалған элементтері бар темірбетон құрылымдарының сейсмикалық сипаттамаларын деформация қабілетіне, яғни энергияны тарату қабілетіне негізделген құрылымдық сипаттамалардың төмендеу коэффициентін қолдана отырып, сандық және тікелей бағалау керек. Бұл радиомен басқарылатын құрылымдардың сейсмикалық сипаттамаларын дәл бағалауға мүмкіндік береді. Зерттеудің негізгі мақсаты-коррозиядан зақымдалған элементтері бар темірбетон құрылымдарының сейсмикалық сипаттамаларын бағалаудың практикалық әдістемесін ұсыну. Тот басқан элементтердің беріктік-деформациялық қабілетімен анықталатын құрылымдық сипаттамалардың нашарлау коэффициенті олардың сейсмикалық сипаттамаларын сандық және тікелей бағалау үшін қолданылады.

Seismic characteristics of reinforced concrete buildings with elements damaged by corrosion should be evaluated quantitatively and directly using a coefficient of reduction in structural characteristics based on the ability to deform, that is, the ability to dissipate energy. This will allow us to accurately assess the seismic characteristics of radio-controlled structures. The main purpose of the study is to propose a practical methodology for assessing the seismic characteristics of reinforced concrete buildings with elements damaged by corrosion. The coefficient of deterioration of structural characteristics, determined by the strength-deformation ability of rusted elements, is used for quantitative and direct assessment of their seismic characteristics.
УКРАИНАНЫҢ ТЕМІРЖОЛ КӨЛІГІНІҢ ТЕХНОЛОГИЯЛЫҚ БАЙЛАНЫС ЖЕЛІЛЕРІН ДАМЫТУ ПЕРСПЕКТИВАЛАРЫ
Authors: АСТАХОВ В.Н. , ВОЛКОВ А.С.
Published: February 2023

В статье проведен анализ структуры и функциональных особенностей существующей телекоммуникационной сети железнодорожного транспорта Украины. Показано, что актуальной научно-практической задачей является организация интегральной сети связи железнодорожного транспорта Украины. Решение поставленной задачи тесно связано с подготовкой высококвалифицированного эксплуатационного штата структурных подразделений железнодорожного транспорта Украины. С этой целью на базе кафедры транспортной связи Украинской государственной академии железнодорожного транспорта введен в эксплуатацию учебно-тренировочный комплекс интегральной сети технологической связи.

Мақалада Украинаның теміржол көлігінің қолданыстағы телекоммуникациялық желісінің құрылымы мен функционалдық ерекшеліктері талданды. Өзекті ғылыми-практикалық міндет Украинаның теміржол көлігінің интегралды байланыс желісін ұйымдастыру болып табылады. Тапсырманы шешу Украинаның теміржол көлігінің құрылымдық бөлімшелерінің жоғары білікті пайдалану штатын дайындаумен тығыз байланысты. Осы мақсатта Украинаның мемлекеттік теміржол көлігі академиясының көлік байланысы кафедрасының базасында технологиялық байланыстың интегралды желісінің оқу-жаттығу кешені пайдалануға берілді.

The article analyzes the structure and functional features of the existing telecommunication network of railway transport in Ukraine. It is shown that the actual scientific and practical task is the organization of an integrated communication network of railway transport in Ukraine. The solution of this task is closely connected with the training of highly qualified operational staff of structural divisions of railway transport of Ukraine. For this purpose, on the basis of the Department of Transport Communications of the Ukrainian State Academy of Railway Transport, the training complex of the integrated network of technological communication was put into operation.
ТӨЛЕМДІ ЕСЕПТЕУДІҢ ИННОВАЦИЯЛЫҚ ТЕТІГІ КОММУНАЛДЫҚ ҚЫЗМЕТТЕРГЕ
Authors: БУЛАТБАЕВ Н.
Published: February 2023

При государственном регулировании тарифообразования на коммунальные услуги не обходится без учета платёжеспособности потребителей. Расслоение населения не позволяет в полной мере закладывать в тарифную сетку затраты, влияющие на развитие сферы. Актуальность темы обусловлено необходимостью обоснования нового подхода к практическому воплощению в государственном регулировании в сфере коммунальных услуг. Это позволит предоставить справедливый доступ к услугам, а также развить данную отрасль. В качестве исследования выбран г. Актобе Актюбинской области, в том числе его население и базовые субъекты естественных монополии. Выбранные методы исследования как дедукция, функционально-стоимостной анализ, позволили прийти к результату инновационного механизма расчета платежей на основе лимитного потребления коммунальных услуг. Разработанный механизм позволит усовершенствовать механизм государственной политики в сфере коммунальных услуг.

.Коммуналдық қызметтерге тариф белгілеуді мемлекеттік реттеу кезінде тұтынушылардың төлем қабілеттілігі ескерілмей аяқталмайды. Халықтың стратификациясы саланың дамуына әсер ететін шығындарды тарифтік торға толығымен салуға мүмкіндік бермейді. Тақырыптың өзектілігі коммуналдық қызметтер саласындағы мемлекеттік реттеуде практикалық іске асырудың жаңа тәсілін негіздеу қажеттілігімен байланысты. Бұл қызметтерге әділ қол жеткізуге, сондай-ақ осы саланы дамытуға мүмкіндік береді. Зерттеу ретінде Ақтөбе облысының Ақтөбе қаласы, оның ішінде оның халқы және табиғи монополиялардың базалық субъектілері таңдалды. Дедукция, функционалдық-құндық талдау ретінде таңдалған зерттеу әдістері коммуналдық қызметтерді лимиттік тұтыну негізінде төлемдерді есептеудің инновациялық тетігінің нәтижесіне қол жеткізуге мүмкіндік берді. Әзірленген тетік коммуналдық қызметтер саласындағы мемлекеттік саясат тетігін жетілдіруге мүмкіндік береді.

With the state regulation of tariff formation for utilities, it is necessary to take into account the solvency of consumers. The stratification of the population does not allow us to fully include in the tariff grid the costs that affect the development of the sphere. The relevance of the topic is due to the need to substantiate a new approach to practical implementation in state regulation in the field of public utilities. This will provide fair access to services, as well as develop this industry. The city of Aktobe of the Aktobe region, including its population and the basic subjects of natural monopolies, was selected as a study. The chosen research methods, such as deduction, functional and cost analysis, allowed us to come to the result of an innovative mechanism for calculating payments based on the limited consumption of utilities. The developed mechanism will make it possible to improve the mechanism of state policy in the field of public services.
ҚОЛДАНУ АРҚЫЛЫ ҚЫЗМЕТ КӨРСЕТУ ЖЫЛДАМДЫҒЫН АНЫҚТАУ ЖАППАЙ ҚЫЗМЕТ КӨРСЕТУ ТЕОРИЯЛАРЫ
Authors: КЕМЕЛЬБЕКОВ Б.Ж. , БАЙМОЛДИН Г.А. , ЖАНАБАЕВ Д.М.
Published: February 2023

Теория СМО связана непосредственно с разработкой и анализом математических моделей, описывающих процесс обслуживания некоторых объектов, которые поступают на вход обслуживающего прибора в виде некоторого потока, и в общем случае образующего очередь на входе обслуживающего прибора.

ҚМҰ теориясы қызмет көрсететін құрылғының кірісіне белгілі бір ағын түрінде келетін және жалпы жағдайда қызмет көрсететін құрылғының кіреберісінде кезек құратын кейбір объектілерге қызмет көрсету процесін сипаттайтын математикалық модельдерді жасаумен және талдаумен тікелей байланысты.

The theory of CFR is directly related to the development and analysis of mathematical models describing the process of servicing some objects that arrive at the input of the service device in the form of a certain stream, and in general forming a queue at the input of the service device.
Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor
Authors: Hocking Ashleigh Jean , Thomas Elaine May , Prabhakaran Sarita , Jolley Alexandra , Woods Susan Lesley , Soeberg Matthew J. , Klebe Sonja
Published: February 2023

Context.—

Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma.

Objective.—

To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos.

Design.—

We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time.

Results.—

The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations.

Conclusions.—

The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere.