bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMATION OF DIGITAL COMPETENCIES OF HUMAN CAPITAL OF MACHINE-BUILDING ENTERPRISES
Authors: MELNYCHUK Viktoriia , BOIARYNOVA Kateryna
Published: September 2023

Formulation of the problem. The article considers the problem of forming digital competencies of human capital of machine-building enterprises. It has been analyzed that the digital economy defines new requirements for enterprises, and one of the key success factors in it is the availability of highly qualified personnel with digital competencies.

The purpose of the study is to form the outline of digital competencies of human capital necessary for machine-building enterprises.

The main hypothesis is to confirm the trend in the labor market regarding the lack of middle-level personnel who possess digital skills and are provided with an effective plan for evaluating the digital competencies of human capital.

The methodology of scientific research is to ensure the development of human capital of machine-building enterprises with a unified framework of digital competences, based on the results of research using general scientific and special methods.

The results consist in the formation of proposals for the division of digital competences into basic and special digital competences, which, in turn, are divided into functional and operational ones. The functional dependencies of digital competencies of the human capital of machine-building enterprises have been formed, which include education, self-education, the worldview of the employee, biological qualities of the individual, the set of business processes at the enterprise, the peculiarities of production processes, the uniqueness of the software product used at the enterprise and practical experience of acquiring digital competencies. The logical sequence of the implementation of processes related to the improvement of their digital competences is described. The article proposes the creation of an intra-corporate framework of digital competence for a machine-building enterprise based on three levels of requirements for determining the need for the scope of digital competences and choosing the method of its satisfaction. It is noted that the basic level of digital competences of the staff of the machine-building enterprise must correspond to the Framework of digital competences for citizens of Ukraine DigComp 2.1, while the outline of functional and operational digital competences is formed in the article independently.

Conclusions. It was revealed that the proposed projects of digital competence outlines, which meet the real needs of the digital transformation of machine-building enterprises and realize the strategic orientation of the formation of the digital economy of Ukraine, can be applied for planning, analysis and formation of digital competences of the human capital of machine-building enterprises.

Keywords: digitalization; human capital; digital competences; machine-building enterprises; digital technologies.
CAULIFLOWER : SOURCES OF VALUABLE TRAITS FOR BREEDING IN THE SEMIARID SUBTROPICAL CLIMATE ZONE OF THE RUSSIAN FEDERATION
Authors:   N.I. Vavilov All-Russian Institute of Plant Genetic Resources, GADZHIMUSTAPAEVA E.G.
Published: September 2023

The catalogue describes phenological, morphological and agronomic traits of 260 cauliflower cultivars and hybrids in the southern region of Russia. In the studied collection there were 76 late-ripening accessions for the winter crop and 184 early and midearly accessions for the summer/autumn crop. Biochemical analysis of 38 cauliflower accessions was performed at the Biochemistry Department of VIR and the Phytochemistry and Medical Botany Laboratory of the Mountain Botanical Garden, Dagestan Federal Scientific Center, Russian Academy of Sciences. The catalogue presents the results of long-term research (1996–2018) on cauliflower under open-field conditions in the summer/autumn and autumn/winter seasons. The study was conducted by the Group of Genetics Proper and Crop Genetic Resources of Fruits, Vegetables and Grapes, Dagestan Experiment Station of VIR. Cauliflower accessions with a set of useful agronomic traits valuable for breeding were identified. There is an obvious need to comprehensively study the breeding material for the southern region of Russia and develop technology elements for cauliflower cultivation in the Republic of Dagestan. The catalogue is of interest for plant breeders, agronomists, students of agricultural colleges, farmers, and experts in vegetable crop genetic resources.
ALEKSANDR IVANOVICH IVANOV (1934-1988)
Authors:   N.I. Vavilov All-Russian Institute of Plant Genetic Resources, DUK O.V. , DZYUBENKO E.A. ,   N.I. Vavilov All-Russian Institute of Plant Genetic Resources
Published: September 2023

Аlexandr Ivanovich Ivanov, a prominent researcher doctor of agricultural sciences, and leading expert in the sphere of plant genetic resources, worked in the Department of Fodder Crops at VIR from 1963 through 1988. His contribution to the development of agrobiology, evolution, and breeding of forage crops served as a foundation for further research efforts of present-day scientists. A. I. Ivanov's scientific heritage is multifarious and retains its relevance. This book presents major milestones of his life and scientific activities, and the fullest list of his publications. The book is addressed to researchers, teachers, postgraduate and undergraduate students of biological and agricultural universities, specialists in biology-related areas, and historians of natural science.
Artefatos mesopotâmicos no ensino de Matemática: discutindo uma atividade didática sobre Plimpton 322
Authors: Silva Evanildo Borges da , Silva Neto Benjamim Cardoso da , Oliveira Luís Carlos Barbosa de
Published: September 2023

O presente trabalho considera a História da Matemática um forte componente para desenvolvimento cognitivo e compreensão de alunos acerca de conteúdos e conceitos matemáticos estudados em sala de aula. Este trabalho trata-se de um recorte de dissertação de mestrado e apresenta como principal objetivo discutir a construção de uma atividade didática para o ensino de Matemática, com base na exploração de artefatos mesopotâmicos com informações históricas matemáticas. É uma pesquisa qualitativa, bibliográfica e exploratória, que elabora uma atividade didática desenvolvida em uma turma do segundo ano do Ensino Médio. Em sua parte bibliográfica, busca um reforço teórico acerca da História da Matemática na região da Antiga Mesopotâmia e da História da Matemática para o ensino de Matemática, adotando o pressuposto teórico da investigação histórica no ensino de Matemática. O artefato mesopotâmico eleito para este trabalho foi a tábua Plimpton 322 de 1900 a. C. a 1600 a. C. que apresenta uma tabulação de ternas pitagóricas. Uma atividade foi desenvolvida e aplicada com base na investigação histórica sobre o artefato Plimpton 322, de onde aplicou-se um tratamento didático ao artefato para uma aula de 60 minutos de duração, em que se realizou uso de questionário com alunos de forma a sintetizar as percepções dos participantes sobre a mesma e os procedimentos didático-metodológicos adotados com a atividade. Verificou-se que a atividade pode se tornar promissora, uma vez que os alunos se sentem motivados e à vontade para indagar, trabalhar em grupo, estabelecer novos meios de buscar soluções, tornando a aula mais produtiva. Como discussão sobre a atividade é sinalizado a ressignificação de conceitos matemáticos e a percepção de uma Matemática mais humanizada e em construção no decorrer do tempo. A aula com uso da História da Matemática pode indicar uma nova direção para uma fuga do ensino tradicional.
Produção de vídeos digitais em Educação Matemática: um olhar sobre teses e dissertações
Authors: Santos Renan Pereira , Sant'Ana Claudinei de Camargo , Sant'Ana Irani Parolin
Published: September 2023

Este artigo apresenta os resultados de um mapeamento sistemático de literatura que objetivou mapear teses e dissertações que trataram sobre a produção de Vídeos Digitais feito por estudantes integrado ao processo de ensino-aprendizagem de Matemática. Para tal, o estudo selecionou pesquisas de mestrado e doutorado através da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e do Catálogo de Teses e Dissertações da Capes (CTDC), com vistas responder à questão de pesquisa: Quais as características das teses e dissertações a respeito de vídeos produzidos por alunos no âmbito da Educação Matemática? Para tal, foi adotado procedimentos e técnicas para a seleção e tratamento dos dados concernentes ao mapeamento sistemático de literatura apoiados em Fiorentini et al. (2016) e Proença Júnior e Silva (2016). Ao todo, analisamos 15 trabalhos que retratam o quadro das pesquisas sobre vídeos digitais produzidos por estudantes na Educação Matemática, traçando um breve panorama paradigmático relativo à temática, teorias e metodologias adotadas. A discussão dos resultados pode contribuir com pesquisadores que se proponham investigar sobre o tema que se apresenta como estratégia potencial de ensino da matemática escolar e como tema de pesquisa acadêmica.
Uma abordagem de conceitos estatísticos nos Anos Finais do Ensino Fundamental a partir do ciclo investigativo PPDAC
Authors: Nascimento Clarice da Silva , Almeida Luana Cerqueira de , Santos Henrique Luis da Silva , Ribeiro dos Santos Santana Eurivalda
Published: September 2023

A estatística está proposta para ser trabalhada durante toda a Educação Básica, havendo, então, a necessidade da potencialização da discussão de seu ensino em processos de formação continuada. O presente texto tem por objetivo relatar a experiência de uma professora acerca do desenvolvimento de uma sequência de ensino referente à inserção de conceitos estatísticos nos anos finais do ensino fundamental, a partir de sua participação em um processo formativo.  As aulas foram desenvolvidas em duas turmas, sendo do 8º ano e do 9 º ano, no turno vespertino, de uma escola pública da Bahia. A sequência de ensino partiu de uma proposta realizada no Curso de Formação para Professores de Matemática, oferecido pela Secretária de Educação do Município e sendo uma ação extensionista do Grupo de Pesquisa em Educação Matemática, Estatística e em Ciências (GPEMEC). Como resultado do processo formativo, a proposta desenvolvida pela professora buscou abordar conceitos estatísticos a partir do Ciclo Investigativo PPDAC. Nota-se com a realização dessa sequência de ensino que é possível desenvolver o trabalho com conceitos estatísticos de tal forma que haja a participação ativa dos estudantes, dentre eles, estudantes com deficiência, o que reforça a necessidade de processos formativos em parceria Universidade-Escola.
Propagación vegetativa de Petiveria alliacea L. var. alliacea
Authors: Malvicini Gustavo D. , Schroeder María A.
Published: September 2023

El objetivo del presente trabajo fue evaluar la multiplicación de Petiveria alliacea L. var. alliacea mediante estacas en las condiciones agroecológicas del noroeste de la Provincia de Corrientes determinando su época de propagación más adecuada, sustrato más adecuado  y el uso de promotores de enraizamiento. Fueron analizados los factores: tipo de estaca (niveles: estacas terminales y estacas intermedias), tipo de sustrato (niveles: arena y mezcla comercial) y tratamiento con regulador de crecimiento vegetal (niveles: con y sin). El ensayo fue repetido en otoño, invierno y primavera. Una vez obtenidos los resultados de cada ensayo se procedió a realizar su  correspondiente análisis de la variancia previa verificación de la normalidad y test de significancia (Test de Tukey a un nivel  = 0.05) empleándose el software Infostat. El análisis estadístico se realizó para cada fecha de estaqueo, y se evaluaron los factores principales por separado, así como las posibles interacciones. Se concluyó que la multiplicación por estacas es un método rápido y eficiente de propagación asexual de Petiveria alliacea L. var. alliacea. Las estacas intermedias fueron las más convenientes para obtener éxito en el enraizamiento y posterior brotación. El tratamiento de las estacas con ANA no sería necesario mientras el estaqueo se realice en primavera y otoño, pero sí sería conveniente cuando se desee propagar esta especie mediante estacas en invierno. El sustrato arena fue donde se obtuvieron los mayores porcentajes de enraizamiento y brotación.
Las raíces agroecológicas de la provincia del Chaco
Authors: Martínez Gerardo R. , Kees María A.
Published: September 2023

La región chaqueña, previamente a la llegada de los europeos, era un territorio donde sus habitantes conformaban una eco-antropo-organización, siendo parte indisoluble de la naturaleza que los rodeaba. Esta comunión ser humano-naturaleza, comenzó a destruirse con la llegada de los primeros europeos en el siglo XVI, agudizándose esta destrucción a partir de fines del siglo XIX y principios del XX, cuando comenzaron a incrementarse las prácticas de deforestación primero y agricultura luego; ya en esos primeros tiempos, se alzaban voces que alertaban que el camino que se iniciaba no iba a traer consecuencias favorables para la región y sus habitantes. El objetivo del presente artículo es rescatar esas voces y mostrar que en la provincia del Chaco las prácticas sustentables o agroecológicas no son nuevas, sino que hunden sus raíces en la historia territorial, rescatando nombres, alertas, acciones que se desarrollaron desde ámbitos académicos, sociopolíticos y productivos en pos de producir amigablemente con la naturaleza. Para ello se realizó un relevamiento bibliográfico y testimonial de actores del territorio chaqueño. El accionar de personas e instituciones que vienen desarrollando procesos de producción agroecológicos, resalta que esta es una región donde se está disputando fuertemente con el modelo hegemónico del agronegocio. Hoy en día existe un movimiento agroecológico que es continuador de aquellas voces que se alzaron en su momento, cuando aún no sabían que eso que estaban proponiendo se llamaría luego agroecología.
Recopilación de insecticidas, acaricidas y fungicidas registrados para el cultivo de cucurbitáceas en Argentina
Authors: Mambrin Augusto G. , Tarragó José R. , Pinto Ruiz Gabriel A.
Published: September 2023

La extensa y variada producción hortícola en la República Argentina se lleva a cabo de manera intensiva, extensiva e incluso como cultivo de subsistencia en huertas familiares. Sus productos se comercializan principalmente en fresco, razón por la cual deben cumplir con la tan necesaria condición de inocuidad para las familias que los consumen. De acuerdo con esto, el control químico de las distintas plagas que perjudican a esta producción debe basarse en la utilización de productos fitosanitarios debidamente registrados, con bajo impacto en el medio, con un uso responsable, manejo adecuado y considerando el tiempo de carencia y dosis para cada caso. A raíz de todo esto, se elaboró una recopilación bibliográfica de los fitosanitarios registrados para la familia de las Cucurbitáceas con el fin de facilitar a los técnicos la toma de decisiones frente a las diversas situaciones que se presentan a campo a la hora de optar por el control químico. El siguiente trabajo cuenta con tablas por cultivo, elaboradas con los principios activos registrados para cada una de las especies tradicionalmente producidas en el NEA, las cuales son calabaza, melón, pepino, sandía, zapallo y zapallito de tronco o redondo. Además, en el presente trabajo, se brinda los valores del Coeficiente de Impacto Ambiental (EIQ) para cada recomendación de uso lo cual es un criterio más para la selección del principio activo a utilizar.
Kardiyovasküler Cerrahi Sonrası Ağrı Yönetiminde Hemşirelerin Uyguladığı Tamamlayıcı Yöntemler: Literatür Taraması
Authors: ÇAM YANIK Tuğba , ALTUN UĞRAŞ Gülay
Published: September 2023

Amaç: Kardiyovasküler cerrahi sonrası dönemde hastaların deneyimlediği yüksek ağrı düzeyi, kardiyovasküler sistemde istenmeyen komplikasyonlara neden olarak hastaların hastanede kalış sürecinde uzamaya veya ölümüne neden olabilir. Tamamlayıcı yöntemler, istenmeyen olası durumların azaltılmasında ve önlenmesinde kullanılan hemşirelik bakımı uygulamalarındandır. Bu literatür taraması, kardiyovasküler cerrahi sonrası dönemde hastaların deneyimlediği ağrının kontrolüne yönelik hemşirelerin kullandıkları tamamlayıcı yöntemleri incelemek amacıyla yapıldı.

Yöntem: Bu literatür taraması, 25 Eylül 2022-25 Haziran 2023 tarihleri arasındaki Türkçe ve İngilizce dizinlerin taranması ile gerçekleştirildi. Derlemeye, Pubmed, ScienceDirect, Google Scholar ve Yöktez veri tabanları üzerinden “cerrahi girişim sonrası ağrı, kalp cerrahisi, kardiyovasküler cerrahi, hemşirelik, tamamlayıcı yöntemler, müzik dinletme, masaj, akupresür, aromaterapi, progresif kas gevşeme egezersizi” anahtar kelimeleri ile taramalar yapıldı. Mart 2013-Ocak 2023 tarihleri arasında yayınlanan yarı deneysel ve randomize kontrollü araştırmalar literatür taramasına dahil edildi.

Bulgular: Kardiyovasküler cerrahi sonrası dönemde, hastaların ağrısının kontrolüne yönelik 5 müzik dinletme, 5 masaj, 3 akupresür, 3 aromaterapi ve 1 progresif kas gevşeme egzersizi gibi tamamlayıcı yöntemlerin kullanıldığı toplamda 17 araştırma belirlendi. Hemşireler tarafından uygulanan tamamlayıcı yöntemlerin, dahil edilen bütün araştırmalarda kardiyovasküler cerrahi sonrası dönemde hastaların ağrı düzeyini düşürmede etkili olduğu bulundu.

Sonuç: Bu literatür taraması, kardiyovasküler cerrahi sonrası dönemde hemşirelerin kullandığı tamamlayıcı yöntemlerin ağrı kontrolünde etkili olduğunu ve hemşirelerin bu yöntemleri kullandıklarını gösterdi.
Meleis’in Kavram Geliştirme Süreci ile “İnsan” Kavramının Hemşirelik Açısından Analizi
Authors: DEĞİRMEN Nuriye , KANAN Nevin , ERKAL İLHAN Sibel
Published: September 2023

Amaç: Bu çalışma ile hemşirelikte yer alan insan kavramını Meleis’in kavram geliştirme süreci ile analiz etmek amaçlanmıştır.

Yöntem: Hemşirelik kavramları, girişimler kapsamında klinik uygulamalar ile ve nitel metodolojik araştırmalar ile birlikte gelişim göstermiştir. Meleis 1997’de kendi oluşturduğu hemşirelikte kavram geliştirme sürecini tanımlamıştır. Meleis’in kavram geliştirme süreci basamakları olan; tanımlama, ayırt etme, öncekileri ve sonuçları betimleme, örnekleme, karşılaştırma ile sentezleme aşamalarını kapsayan bütünleştirilmiş yaklaşımı ortaya koymuştur. Bu çalışmada Meleis’in kavram geliştirme süreci kullanılarak metodolojik yöntemle insan kavramı incelenmiştir.

Bulgular: Bilimin tanımı bilimsel yöntemler ile oluşturulmuş bilgilerin bütünü olarak ifade edilmekte olup, hemşirelik bilime dayalı teorik ve pratik kapsama sahip bir meslektir. Aynı zamanda hemşirelik profesyonellik üzerine kurulu bir bilim alanıdır. Sağlık alanında önemli bir disiplin olan hemşirelik bilimsel olma adına teorik temellerini meydana getirirken kendi bilim alanı ile ilgili kavramları analiz etmesi, açıklaması ve tanım boyutu ile değerlendirmesi gerekmektedir.

Sonuç: Günümüze kadar hemşirelik alanında geliştirilmiş olan kavramlar çok boyutlu ve karmaşıktır ve de tüm diğer disiplinlerle etkileşim altında oluşturulmaktadır. Bu bağlamda insan kavramının tanımlanması önem arz etmektedir.
Database for Baghdad Soil Using GIS Techniques
Authors: Mohammed Athraa Hashim , Yahya Asmaa Younus , Ahmed Balqees Abdulwahid
Published: September 2023

teen sites Baghdad are made. The sites are divided into two groups, one in Karkh and the other in Rusafa. Assessing the underground conditions can be occurred by drilling vertical holes called exploratory boring into the ground, obtaining soil (disturbed and undisturbed) samples, and testing these samples in a laboratory (civil engineering laboratory /University of Baghdad). From disturbed, the tests involved the grain size analysis and then classified the soil, Atterberg limit, chemical test (organic content, sulphate content, gypsum content and chloride content). From undisturbed samples, the test involved the consolidation test (from this test, the following parameters can be obtained: initial void ratio eo, compression index cc, swelling index cs , coefficient of consolidation cv , coefficient of volume change mv, maximum preconsolidation stress Pc , Effective overburden pressure Po )and shear test (the following parameters can be obtained: undrained cohesion cu, angle of friction φ. In-situ testing was carried out by the standard penetration test in order to obtain the penetration resistance of the soil strata in a bore hole. Database for Baghdad soils is made using different GIS techniques connecting the spatial locations of those soils with their properties (ِAtterberg Limits, Specific Gravity, Grain size Analysis, Shear Strength parameters, Consolidation parameters), Borehole log, Site profile using the attribute tables, hyperlinks, metadata and SQL (System Query Language), so GIS techniques give the facilities for adding, editing and analyzing the existingdata as well as the any future data of Baghdad soils.
Philosophical foundations and aesthetic principles of dance art in China and Russia: the search for harmony and spiritual perfection
Authors: Jingjing Zhang , Lei Yin
Published: September 2023

This article presents a comparative analysis of the ideological connotation and philosophy of dance art in China and Russia. The research is based on the comparison and analysis of the historical and modern contexts of the dance traditions of both countries, their connection with culture and ideology, as well as their influence on the formation of national identity. The results of the analysis will allow a deeper understanding of the role of dance art in society and its reflection of ideological attitudes and philosophical principles in China and Russia.
Relations between Russia and Pakistan in the 21st century: dynamics and prospects
Authors: Xu Zhu , Lin Ye
Published: September 2023

The article examines the relations between Russia and Pakistan in the 21st century. The article notes that cooperation between Russia and Pakistan is carried out both in a bilateral format and within the framework of international organizations and multilateral structures.
RHOV is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ras homolog family member V, encoded by RHOV, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. RHOV mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of RHOV in primary tumors was correlated with patient distant metastasis-free survival. Modulation of RHOV expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
GAPDH is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that glyceraldehyde-3-phosphate dehydrogenase, encoded by GAPDH, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. GAPDH mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of GAPDH in primary tumors was correlated with overall, distant metastasis-free and recurrence-free survival. Modulation of GAPDH expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Indicadores de control para mejorar la toma de datos y el sistema de datos y estadísticas de las bibliotecas públicas de España
Authors: Lázaro-Rodríguez Pedro , Aguilar-Soto María
Published: September 2023

El objetivo de este trabajo es presentar 5 indicadores de control para mejorar el sistema de datos y estadísticas de las bibliotecas públicas de España. Los indicadores se refieren al presupuesto en personal, a las actividades culturales organizadas y asistentes, y a las personas usuarias inscritas y las prestatarias activas. Con la presentación y el cálculo de los indicadores a nivel de municipios de España para el año 2021, detectamos y comentamos (posibles) errores en los datos. Desde ahí, reflexionamos sobre posibles formas de mejora en tres sentidos: acciones que pueden llevarse a cabo desde las bibliotecas, desde el sistema de datos y estadísticas de bibliotecas públicas de España, y acciones para las personas que investigamos sobre ello. El valor y la originalidad del trabajo radican en que los indicadores de control desarrollados son originales, sin conocerse su cálculo y propuesta en trabajos previos, y que se calculan al nivel de municipios y no de provincias y/o comunidades autónomas como suele hacerse. Además, la finalidad principal es mejorar los datos para que nos permitan conocer de una manera real y sólida lo que está ocurriendo en el día a día de las bibliotecas. [English: The purpose of this paper is to present 5 control indicators to improve the data and statistics system of public libraries of Spain. The indicators are refereed to the budget for the staff, to the organized cultural activities and attendees, and to the registered users and active borrowers. With the presentation and calculation of the indicators at the level of municipalities in Spain for the year 2021, we detect and comment on (possible) errors in the data. From there, we discuss possible ways for the improvement in three ways: actions that can be carried out by and from the libraries, from the data and statistics system of public libraries in Spain, and actions for the researchers on this topic. The value and originality of the work lies in the fact that the control indicators developed are original, without their calculation and proposal being known in previous works, and that they are calculated at the level of municipalities and not at the level of provinces and/or autonomous communities as is usually done. In addition, the main purpose is to improve the data so that they allow us to know in a real and solid way what is happening on a daily basis in the libraries.]
MYRFL is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that myelin regulatory factor-like, encoded by MYRFL, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. MYRFL mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of MYRFL in primary tumors was correlated with patient distant metastasis-free survival. Modulation of MYRFL expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
MRPS12 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that mitochondrial ribosomal protein S12, encoded by MRPS12, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. MRPS12 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of MRPS12 in primary tumors was not correlated with patient survival outcomes. Modulation of MRPS12 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
DNAH11 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that dynein axonemal heavy chain 11, encoded by DNAH11, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. DNAH11 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of DNAH11 in primary tumors was correlated with overall and distant metastasis-free survival. Modulation of DNAH11 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
ZIC4 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that Zic family member 4, encoded by ZIC4, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ZIC4 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of ZIC4 in primary tumors was correlated with patient overall and recurrence-free survival. Modulation of ZIC4 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Control of APOBEC3B by NOD2.
Authors: Mamoor Shahan
Published: September 2023

We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of apolipoprotein B mRNA editing enzyme catalytic subunit 3B APOBEC3B expression by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
ADAM15 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ADAM metallopeptidase domain 15, encoded by ADAM15, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ADAM15 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of ADAM15 in primary tumors, however, was not correlated with patient survival outcomes. Modulation of ADAM15 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Space-time data-driven modeling of precipitation-induced shallow landslides in South Tyrol, Italy
Authors: Moreno Mateo , Lombardo Luigi , Crespi Alice , Zellner Peter , Mair Volkmar , Pittore Massimiliano , van Westen Cees , Steger Stefan
Published: September 2023

Shallow landslides represent potentially damaging processes in mountain areas worldwide. These geomorphic processes are usually caused by a combination of predisposing, preparatory, and triggering environmental factors. At regional scales, data-driven methods have been used to model shallow landslides by addressing the spatial and temporal components separately. So far, few studies have explored the integration of space and time for landslide prediction. This research leverages generalized additive mixed models to develop an integrated approach to model shallow landslides in space and time. We built upon data on precipitation-induced landslide records from 2000 to 2020 in South Tyrol, Italy (7,400 km²). The Slope Unit-based model predicts landslide occurrence as a function of static and dynamic factors while seasonal effects are incorporated. The model also accounts for spatial and temporal biases inherent in the underlying landslide data. We validated the resulting predictions through a suite of cross-validation techniques and tested potential applications. The analysis revealed that the best-performing model combines static ground conditions and two precipitation time windows: short-term cumulative precipitation prior to the landslide event and medium-term cumulative precipitation. We tested the model's predictive capabilities by predicting the dynamic landslide probabilities over hypothetical non-spatially explicit precipitation scenarios and historical precipitation associated with a heavy precipitation event on August 5th, 2016. The novel approach shows the potential to integrate static and dynamic landslide factors for large areas, accounting for the underlying data structure and data limitations.
Zero inflation in intensive longitudinal data: why is it important and how should we deal with it?
Authors: Shao Sijing , Xu Ziqian , Liu Qimin , McClure Kenneth , Jacobucci Ross , Maxwell Scott E. , Zhang Zhiyong
Published: September 2023

This study addresses the challenge of analyzing ecological momentary assessment (EMA) data with zero-inflated autoregressive processes. EMA data, characterized by intensive longitudinal measurements, often exhibit excessive zeros and temporal dependencies. Neglecting zero-inflation or mishandling it can lead to biased parameter estimates and inaccurate conclusions. To overcome this issue, we propose a novel Zero-Inflated Process Change multilevel AutoRegressive model (ZIP-CAR) model that incorporates zero-inflation using a Bayesian framework. We compare the performance of the proposed method with existing methods through a simulation study and demonstrate its advantages in accurately estimating parameters and improving statistical power. Additionally, we apply the ZIP-CAR model to a real EMA dataset on problematic drinking behaviors, highlighting its effectiveness in capturing autoregressive and cross-lag effects while accounting for zero-inflation. The results underscore the importance of addressing zero-inflation in EMA data analysis and provide practical recommendations for researchers. Our proposed model offers a valuable tool for analyzing EMA data with zero-inflated autoregressive processes, facilitating a more comprehensive understanding of dynamic behavioral changes over time.
Prolegomena to a cognitive science of language diversity
Authors: Benítez-Burraco Antonio
Published: September 2023

Linguistics needs to embrace all the way down the cognitive implications of a key feature of language facts: its diversity. In this paper, we build on recent findings about the neuroscience of linguistic variation, but also on proposals by theoretical biology, to sketch some prolegomena to a future cognitive science of language diversity. We argue that the cognitive foundations of human language cannot be adequately understood without considering four dimensions of variation: the different functions performed by language, the diversity of sociolinguistic phenomena, the typological differences between human languages, and the diverse developmental paths to language. If we succeed in the cognitive examination of these four dimensions, we will not only achieve a more comprehensive understanding of how our brain processes language, but also of how language evolved, as their consideration should enable to find more evolutionary continuity between language and the cognitive abilities of other species. Overall, the approach we advocate for here is expected to result in a more accurate view of human language within the architecture of human cognition.
PEREMPUAN DAN PERDAGANGAN IKAN LAUT DI PESISIR BESUKI KABUPATEN SITUBONDO JAWA TIMUR
Authors: Badri Mohamad il , Rohmawati Rina
Published: September 2023

Keterlibatan perempuan menjadi biasa dan bukan masalah hanya demi untuk terpenuhinya kebutuhan hidup sehari-hari. Perempuan ikut terlibat dalam perdagangan hasil tangkap ikan. Perempuan berbondong di tepian dermaga untuk mengambil ikan hasil tangkapan para nelayan laki laki yang umumnya adalah suami-suami nelayan perempuan. Dengan berbekal  timbangan kecil para perempuan berkerumun di TPI pada dini hari, umumnya masyarakat pesisir menyebutnya Reng Timbengan. Aktifitas perdagangan pada dini hari terlihat sudah umum dalam masrakat di kalangan perempuan nelayan Pesisir Besuki. Mereka terlibat aktif untuk mempertahankan perekonomian keluarga dengan bentuk kerja sama yang sangat hebat. Tidak ada istilah tabu dalam peran ini, sebab meraka memahami bagaimana dapat bekerja dengan memperoleh hasil maksimal untuk kelangsungan hidup rumah tanggan nelayan tradisional. Kajian ini menarik menurut penulis sebab tidak semua wilayah pesisir memiliki keunikan dalam peran perempuan yang ikut terlibat dalam perdagangan ikan meski hanya dalam kapasitas yang kecil. Peran ekonomi rumah tangga nelayan yang sudah disepakati dengan tujuan untuk keberlangsungan ekonomi rumah tangga nelayan sederhana.
Atypical Septic Cerebral Embolism in the Fatal Infective Endocarditis
Authors: Jinbo Chen or Hongcai Wang Ruli Ge or
Published: September 2023

Streptococcus agalactiae (GBS) is an unusual cause of infectious endocarditis. At present, evidence suggest that the increasing impact invasive GBS disease occurs on adults. A 51-year old man, had a history of cirrhosis, fundus, esophageal varices, upper gastrointestinal bleeding for 11 years, with spleen resection, fundus and esophageal varices ligation. First clinical feature as right wrist and finger movement dysfunction with low-grade fever was described. Cerebral embolism induced by severe infectious endocarditis was confirmed by MRI+DWI in the early stage. The cardiac color Doppler showed the development of aortic valve vegetation (10 mm x 10 mm), which moved into the aortic sinus in systolic phase and the left ventricular outflow tract, severely affecting hemodynamics. ST-segment depression in the ECG and the elevated serum troponin were indicated. Bacterial isolates from blood cultures revealed that Streptococcus agalactiae (Group B Streptococcus) infection. Despite the infection control and supportive treatment, the patient's condition continued to deteriorate, characterized by intermittent fever, chest pain, sitting breath and coughing up pink and foam sputum. Acute left heart failure was confirmed by echocardiography. The cardiac surgery was complicated and have high risk. The patient eventually died of myocardial infarction and heart failure. Infectious endocarditis should be considered in patients without native valve disease who have cerebral infarction involving anterior and posterior circulation of cerebral artery and prolonged fever. Considering the severity of GBS infection, early recognition and prompt treatment was cardinal importance for the forward prognosis of infectious endocarditis.
Medium Term Study of Incidence, Risk Factors and Type of Stroke in Hypertensive Patients
Authors: Zou Ji-Ming
Published: September 2023

Background and Aims: To investigate the incidence and risk factors of stroke in hypertension patients over 60 years of age, and to investigate the correlation. Methods: A retrospective analysis of 454 hypertension patients who were diagnosed through examination were divided into 4 groups, of which included group A (hypertension plus type 2 diabetes) were 4 cases, group B (hypertension plus hyperlipidemia) were 367 cases, group C (hypertension plus type 2 diabetes and hyperlipidemia) were 47 cases, and group D (hypertension) were 36cases. Every patient was given observation after definite diagnosis and treatment of 54 months, and to investigate the incidence of acute cerebral infarction, cerebral hemorrhage. Results: There were 44 patients occurred acute cerebral infarction in all 4 groups. Of these cases, there were 1 case in group A, 31 cases in group B,10 cases in group C and 2 cases in group D. In group B, 3 cases occurred cerebral hemorrhage. Logistic regression analysis showed systolic blood pressure (OR=1.106, P=0.001), fasting glucose (OR=2.059, P=0.000) and low-density lipoprotein cholesterol (LDL-C) (OR=0.104, P=0.025) were risk factors for stroke. Conclusions: Higher levels of blood glucose and/or blood lipid associate with higher risk of stroke in patients with hypertension.
Alternative Splicing Changes in Human Aging Brain Samples
Authors: Soreq Lilach
Published: September 2023

Alternative splicing affects differential isoform generation from genes and may also affect the protein products cellular function. Targeted splicing analysis of exon array analysis of young compared to middle and old post mortem brain samples from 1,234 samples (a total of 10 brain regions) aged from 16 to over 100 allowed me to detect significant alternative splicing changes upon human aging. This kind of data may allow us to better understand the underlying molecular mechanisms.
The Prevention of the Birth of an Autistic Child is Simpler than its Cure
Authors: Parle Milind
Published: September 2023

Impressive intellect and extrovert nature exhibited by the child spring from both, the supremacy of protective factors during nine months of the gestation period and the favorable genes of the parents. There is no approved allopathic, homeopathic, or ayurvedic medicine for the treatment of autism spectrum disorder or any neurodevelopmental childhood disease for that matter. The challenges faced by the lady during pregnancy and the delivery of the child, therefore need to be delicately addressed so that the birth of an abnormal child does not occur in the first place. The intellectual and physical personality of the unborn child is dependent on the sound health of the pregnant lady during gestation, proper nutrition, and a loving home environment. Thus, the prevention of the birth of an autistic child is the only reasonable option available at present and appears to be simpler than its cure. We believe that the society at large in India and around the world would greatly benefit from this review article.
Lower Thoracic Spinal Myeloradiculopathy with Intramedullary Schwannoma in an Elderly Woman: A Rare Case Report
Authors: Reyhan Syawal Muhammad
Published: September 2023

Intramedullary schwannomas are a rare form of spinal tumors. Here, we present a case of a 61-year-old woman who was admitted to our hospital with complaints of weakness in both lower extremities, numbness, urinary and defecation disorders, and radiculating back pain. Physical examination revealed sensory and motoric deficits in the lower extremities, as well as autonomical dysfunctions. Radiological imaging revealed a mass at the lower level of thoracic spinal segment, which was confirmed as a schwannoma through histopathological analysis. The patient underwent laminectomy tumor removal and posterior stabilization. She was also diagnosed with type 2 diabetes mellitus and hypertension. Spinal intramedullary schwannoma is a rare condition that requires a thorough history and physical examination for diagnosis, particularly for patients with neurological impairments. Prompt treatment is essential once the diagnosis is made.
The Effect of Dietary Preferences on Academic Performance Among Kindergarten-Aged Children
Authors: Mualem Raed
Published: September 2023

This study examines the impact of kindergarten children's dietary preferences on their cognitive performance and social relationships, with a focus on traditional foods versus processed foods. The research demonstrates that a child's choice of breakfast can significantly affect their cognitive abilities, including memory and concentration, as well as their interpersonal relationships. Traditional foods like salads and olive oil are found to increase cognitive abilities, while processed foods like hot dogs and chocolate sandwiches can be detrimental to academic performance and social behavior. The study utilized puzzle games and card games to evaluate cognitive abilities and found that a processed diet can lead to decreased focus, hyperactivity, and impaired social relationships. QEEG analysis contributes to the existing body of evidence indicating that a traditional diet can enhance academic performance. The study highlights the importance of educating parents about the advantages of a traditional diet and encourages them to prepare breakfast together with their children using traditional foods like olive oil and salad to enhance academic performance and social relationships. The findings offer valuable insights into the importance of a traditional diet for young children's education and highlight the need for greater attention to be given to diet as an important factor in children's academic success.
Споживання цукру: світові тренди
Authors:   Державний податковий університет, ЧОРНА Тетяна , ГУСЯТИНСЬКА Наталія ,   Національний університет харчових технологій
Published: September 2023

Представлено результати дослідження світових та вітчизняних тенденцій вироб­ництва й споживання цукру, отриманого з цукрових буряків та цукрової тростини; систематизовано дані щодо асортименту й основних характеристик різних видів цукру, який пропонується на світових товарних ринках; проведено аналіз асортименту про­дукції українських цукрових заводів; окреслено перспективи вітчизняних цукровиробників щодо задоволення споживчого попиту та підвищення конкурентоздатності вітчизняної продукції. Використано загальнонаукові методи – збір інформації, її аналітичне опрацювання та теоретичне узагальнення; статистичні методи – для кількісної оцінки обсягів спожи­вання цукру; графічний – для ілюстрації динаміки досліджуваних у роботі показників. Встановлено, що в найближчій перспек­тиві у світі зберігатиметься тенденція до зростання обсягів виробництва цукру. Щодо глобального споживання цукру на душу населення, то загалом прогнозується його повільне скорочення. Водночас якщо у розвинених країнах не очікується збільшення загального споживання цукру в наступному десятилітті, то для країн, що розвиваю­ться, таке зростання прогнозується внаслідок збільшення доходів населення й урбанізації. Споживання цукру в Україні на душу населення перебуває на досить висо­кому рівні, хоча простежується тен­денція до щорічного зниження показника. В останні десятиліття значно збільшився перелік видів цукру, який виробляється вітчиз­ня­ними цукро­вими заводами. Разом з тим актуальним завданням для українських цукро­виробників є подальший розвиток асор­тименту продукції з урахуванням світових тенденцій. Завдяки випуску нових видів цукру вітчизняні заводи отримують мож­ливість гідно конкурувати з анало­гічною про­дукцією імпортного вироб­ницт­ва. Перспективним напрямом розши­рення асорти­менту цукропродуктів є вироб­ництво орга­нічних продуктів, а також цукрів зі збага­ченим макро- та мікро­елементним складом.