bluuebunny/crossref_metadata_2025 huggingface dataset:
Macrolide resistance is pervasive in oral streptococci in the Belgian general population: a cross-sectional survey
Authors: Vanhout Zoë , Abdellati Saïd , Gestels Zina , De Baetselier Irith , de Block Tessa , Vanbaelen Thibaut , Manoharan-Basil Sheeba Santhini , Kenyon Chris
Published: November 2024

Background. Commensal streptococci are common inhabitants of the oral microbiome and regulate its structure and function in beneficial ways for human health. They can, however, also be opportunistic pathogens and act as a reservoir of resistance genes that can be passed on to other bacteria, including pathogens. Little is known about the prevalence of these commensals in parents and their children and their antimicrobial susceptibilities in the Belgian general population.

Gap Statement. The macrolide susceptibility of commensal oral Streptococci in Belgium is unknown.

Methods. We assessed the prevalence and azithromycin susceptibility of commensal streptococcal species in the parents (n=38) and children (n=50) of 35 families in Belgium.

Results. The most frequently detected taxonomic grouping was Streptococcus mitis/oralis, which was detected in 78/181 (43.1%) of the children’s isolates and 66/128 (51.6%) of the parents’ isolates. Of the 311 isolates collected in this study, 282 isolates (90.7%) had an azithromycin MIC value greater than the breakpoint of 0.25 mg l−1 and 146 isolates (46.9%) had azithromycin MICs greater than 2 mg l−1. There was no difference in the azithromycin MIC distribution of all streptococcal isolates between children and parents. All individuals were colonized by streptococci with azithromycin MICs greater than 0.25 mg l−1, and 87.5% of individuals had streptococci with MICs greater than 2 mg l−1.

Interpretation. The most prevalent species identified in both age groups was S. mitis/oralis. All individuals harboured streptococci with macrolide resistance. This highlights the need for additional antimicrobial stewardship initiatives to reduce the consumption of macrolides in the general population.
Human Stem Cell-derived Kidney Collecting Duct Model via Epithelial Microphysiological Analysis Platform: Epi-MAP
Authors: Hong SoonGweon , Song Minsun , Patel Ankit , McCracken Kyle W. , Bonventre Joseph V. , Lee Luke P.
Published: November 2024

The kidney epithelium’s pivotal role in molecular filtration, metabolism, and excretion highlights the crucial importance of understanding kidney physiology in drug development. However, our knowledge is largely derived from non-human or non-physiological models, potentially limiting its applicability to humans. To address this significant gap, we have pioneered a human kidney epithelial microphysiological analysis platform (Epi-MAP) designed to establish, mature, and monitor renal functions of the human collecting epithelium within a physiologically relevant microenvironment. We first demonstrate the highly mature collecting duct physiology derived from human stem cells, enabled by the Epi-MAP’s microenvironments that recapitulate in vivo asymmetries in fluidic and biochemical conditions. The integrated biosensors of the Epi-MAP provide long-term, time-resolved epithelial maturation trajectories, revealing advanced integrity and functional maturity with transepithelial metrics. Furthermore, Epi-MAP’s electrophysiological analytics for measuring water flux, in conjunction with transepithelial potential and resistance, allow for real-time decoding of intricate epithelial responses to substance stimulation, showcasing its effectiveness as a robust pharmacological test model. This human cell-derived, physiologically advanced model on a chip stands as a robust in vitro tool, offering comprehensive insights into human kidney biology and significantly enhancing drug discovery process based on human physiology.
Re-calibration of flow cytometry standards for plant genome size estimation
Authors: Soni Abhishek , Henry Robert J
Published: November 2024

The evolution of long-read sequencing technologies has advanced the development of genome assemblies that are now frequently presented as gap-free or nearly gapless, reflecting substantial improvements in sequencing accuracy and completeness. However, discrepancies between the genome size estimates derived from genome assemblies and flow cytometry create ambiguity regarding the accuracy of these complementary approaches. Accurate genome size estimation via flow cytometry relies on use of an internal standard with a genome of known size. Historically, the genome size of these standards was often calibrated against incomplete genome assemblies or non-plant genomes, such as the human male genome, which was previously considered to be 7 pg but is now known to be around 6.15 pg after 20 years of advancements. Calibrating plant references against non-plant standards is not recommended due to differential staining properties. Therefore, we recalibrated the size of five plant genomes commonly used as reference standards in flow cytometry, by utilizing a recent gapless, telomere-to-telomere (T2T) genome assembly of Nipponbare rice. Our results indicate a significant overestimation of around 20% in previous flow cytometry-based estimates forPisum sativumandNicotiana benthamiana, around 10% forArabidopsis thaliana, and less than 5% forSorghum bicolor, andGossypium hirsutum. The close alignment of the recalibrated GS estimates to the reference genome assemblies and recalculated estimates from different studies confirms their suitability as reference standards for more accurate measurement of plant genome size.
Efficacy of Tirzepatide Dual GIP/GLP-1 Receptor Agonist In Patients with Idiopathic Intracranial Hypertension. A Real-World Propensity Score-Matched Study
Authors: Azzam Ahmed Y. , Essibayi Muhammed Amir , Farkas Nathan , Azab Mohammed A. , Morsy Mahmoud M. , Elamin Osman , Elswedy Adam , Al Zomia Ahmed Saad , Alotaibi Hammam A. , Alamoud Ahmed , Atallah Oday , Abukhadijah Hana J. , Dmytriw Adam A. , Baker Amanda , Khatri Deepak , Haranhalli Neil , Altschul David J.
Published: November 2024

Introduction

Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure, predominantly affecting obese women of reproductive age. While GLP-1 receptor agonists have shown promise in IIH management, the potential of dual GIP/GLP-1 receptor activation through tirzepatide remains unexplored. This study aimed to evaluate tirzepatide’s efficacy as an adjunctive therapy in IIH management.

Methods

We conducted a retrospective cohort analysis using the TriNetX Global Health Research Network, analyzing data through November 2024. Through propensity score matching, we compared 193 tirzepatide-exposed IIH patients with 193 controls receiving standard care. Primary outcomes included papilledema severity, visual function, headache frequency, and treatment resistance, monitored at multiple follow-up timepoints.

Results

Our analysis revealed significant improvements across all measured outcomes in the tirzepatide group. At 24 months, we observed a 68% reduction in papilledema risk (RR 0.320, 95% CI 0.189-0.542, p<0.001), a 73.9% reduction in visual disturbance and blindness risk (RR 0.261, 95% CI 0.143-0.477, p<0.001), and a 19.7% reduction in headache risk (RR 0.803, 95% CI 0.668-0.966, p=0.019). The tirzepatide group demonstrated significant body-mass index reductions, reaching -1.147 kg/m2(95% CI [-1.415, -0.879], p<0.001) at 24 months compared to controls.

Conclusions

Our results demonstrate that tirzepatide, when used as an adjunctive therapy, provides significant therapeutic benefits in IIH management, particularly in improving papilledema and visual outcomes. Our findings suggest that dual GIP/GLP-1 receptor activation may offer advantages over traditional single-receptor therapies, potentially through enhanced metabolic regulation and direct effects on intracranial pressure dynamics.
Optimized Plaque Assay for Detecting Chronically Infecting Viruses of Haloarchaea
Authors: Navok Sharon , Cohen Lee , Ron Eliora Z. , Gophna Uri
Published: November 2024

Archaeal viruses predominantly exhibit a chronic lifestyle, where viral particles are released without causing host cell death. Therefore, conventional plaque assays, which are well-suited for identifying lytic viruses, usually fail to detect chronically infecting viruses due to their non-lytic nature. To address this limitation, we developed an optimized plaque assay protocol for detecting chronically infecting viruses of haloarchaea, particularly species within theHaloferaxgenus. By enhancing viral diffusibility and infectivity through adjustments in agar concentration and lowering incubation temperature, this modified protocol improved plaque formation, enabling the detection of viruses that cause mild growth delays. We demonstrate successful plaque formation for two chronically infecting viruses,Haloferax volcaniipleomorphic virus 1 (HFPV-1) and lemon-shaped virus 48N (LSV-48N), on representativeHaloferaxstrains and highlight the potential for isolating novel viruses from environmental samples. This improved plaque assay is an effective method for the detection and quantification of chronically infecting archaeal viruses, providing a new tool for discovering new viral families in extreme environments.
Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool
Authors: Toghani Dorsa , Gupte Sanika , Zeng Sharon , Mahammadov Elmir , Crosse Edie I. , Seyedhassantehrani Negar , Burns Christian , Gravano David , Radtke Stefan , Kiem Hans-Peter , Rodriguez Sonia , Carlesso Nadia , Pradeep Amogh , Georgiades Alexis , Lucas Fabienne , Wilson Nicola K. , Kinston Sarah J. , Göttgens Berthold , Zong Le , Beerman Isabel , Park Bongsoo , Janssens Derek , Jones Daniel , Toghani Ali , Nerlov Claus , Pietras Eric , Mesnieres Marion , Maes Christa , Kumanogoh Atsushi , Worzfeld Thomas , Cheong Jin-Gyu , Josefowicz Steven Z , Kharchenko Peter , Scadden David T. , Scialdone Antonio , Spencer Joel A , Silberstein Lev
Published: November 2024

Somatic stem cell pools are comprised of diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In the bone marrow, myeloid-biased HSC (myHSC) are indispensable for replenishment of myeloid cells and platelets during inflammatory response but at the same time, become irreversibly damaged during inflammation and aging. Here, we identify an extrinsic factor, Semaphorin 4A (Sema4A), which non cell-autonomously confers myHSC resilience to inflammatory stress. We show that the absence of Sema4A, myHSC inflammatory hyper-responsiveness in young mice drives excessive myHSC expansion, myeloid bias and profound loss of regenerative function with age. Mechanistically, Sema4A is mainly produced by neutrophils, signals via a cell surface receptor Plexin D1 and safeguards myHSC epigenetic state. Our study shows that by selectively protecting a distinct stem cell subset, an extrinsic factor preserves functional diversity of somatic stem cell pool throughout organismal lifespan.
Horizon problem and capital expenditures: evidence from the public sector in Indonesia
Authors: Rakhman Fuad , Na'im Ainun , Saudagaran Shahrokh
Published: November 2024

Purpose

This study investigates whether horizon problems affect the allocation of capital budgets and their implementation in a government setting.

Design/methodology/approach

We use data from 2005 to 2020 for local governments in Indonesia, which apply a limit of two five-year terms for mayors. We use regression analyses for panel data with total observations of 4,541 local government years from 448 unique local governments. We also use graphical analyses and t-tests to provide robustness to our results.

Findings

Mayors allocated lower capital expenditures in the second term than in the first. Capital budget allocation is lower for local governments whose mayors are older than 60. Our additional analysis shows that incumbents seeking re-election allocate more capital expenditure than those not seeking re-election.

Research limitations/implications

This study contributes to the literature on the behavioral effect of term limits on local government's allocation and implementation of capital budgets. Limiting elected government officials to a certain number of terms will prevent the monopoly of power. However, it may negatively affect budget allocation on capital programs in their last term. Our findings should interest public policymakers in discerning the costs and benefits of term limits for elected offices.

Originality/value

Most studies on horizon problems have focused on the corporate setting. This study provides evidence of the effects of horizon problems in the government setting, especially in Asia.
The interaction of blockchain technology, audit process, and the International Financial Reporting Standards
Authors: Arianpoor Arash , Borhani Seyed Abbas
Published: November 2024

Purpose

This study aims to provide a framework for the interaction of blockchain technology, the audit process and International Financial Reporting Standards (IFRS).

Design/methodology/approach

This study was conducted in three phases. In the first phase, a meta-synthesis method was used until 2020. Out of 87 papers, a total number of 15 were selected, and 72 were excluded after an initial screening. In the second phase, 11 interviews were held with experts with sufficient experience and expertise in blockchain technology, accounting and auditing. These interviews were held between 2020 and 2021. The sampling was purposive (targeted) in type, along with snowball sampling. In the third phase, a combination of questionnaire-based method and the fuzzy Delphi method was used. The research population for this phase consisted of accounting professors, members of the Iranian Association of Certified Public Accountants and accounting and technology professionals. Following the selection of the Delphi panel, 35 questionnaires were collected between 2021 and 2022 for analysis.

Findings

The results showed that in line with the interaction of blockchain technology, audit process and IFRS, 52 indicators were confirmed in eight components. Moreover, “Verifiability,” “Timeliness” and “Predictive value” were the most influential factors, respectively, according to the conceptual model. In addition, higher average scores of experts’ views were related to “Transparency audit reports” and “Increasing the quality of the auditor’s judgment”, respectively.

Originality/value

Blockchain is a complex subject, and there has been very little published research on the intersection of IFRS and blockchain technology. It is crucial for the audit profession and technology professionals to focus on the interaction of blockchain technology with the qualitative characteristics of information. This is an area that has not been thoroughly researched yet. The interaction of blockchain technology, improvements in the audit process and adherence to IFRS is a significant development in accounting and auditing.
Is “Collaborative Governance” or “Competitive Collusion” the effect of cross-ownership on corporate innovation
Authors: Yang Lijuan , Xiao Lijuan , Xiong Lingyun , Wang Jinjin , Bai Min
Published: November 2024

Purpose

Using Chinese A-share listed firms between 2007 and 2020 with 21,380 observations, we aim to examine the impact of cross-ownership on firms’ innovation output and explore the underlying mechanisms.

Design/methodology/approach

To test the influence of cross-ownership on firms’ innovation output, this paper constructs an ordinary least square regression model. The explained variables are firms’ innovation output, including the total number of patent applications (Apply) and the number of invention patent applications (Apply_I). Considering the long period of patent R&D, we take the value of the explained variables in the following year for regression. Cross-ownership (Cross) is the explanatory variable; Control is the control variable; and ε is the regression residual term.

Findings

We find that cross-ownership significantly promotes corporate innovation output, indicating that cross-owners play an important role in “collaborative governance.” This finding remains unchanged after conducting a series of robustness tests. We also find that cross-ownership contributes to innovation output mainly through two plausible channels: the relaxation of financing constraints and reducing both types of agency costs. Further analysis shows that cross-ownership has a more pronounced influence on innovation output in those firms with higher equity restriction ratios and facing more competitive markets. Moreover, cross-ownership has a profound impact on firms’ innovation quality and innovation efficiency, thereby increasing firm value.

Research limitations/implications

This study provides important policy implications. First, cross-owners should actively play their resource and supervision advantages to improve firms’ long-term development capability through the “collaborative governance” effect. Second, listed companies in China should be fully aware of the value of the cross-ownership and use the cross-ownership as a bridge to strengthen the cooperative relationship with firms in the same portfolio. Meanwhile, they need to pay attention to cross-ownership’s “collaborative governance” effect to provide an impetus for the healthy development of enterprises. Finally, government regulators should maintain appropriate supervision of the cross-ownership linkage in the market.

Originality/value

Our findings show that cross-ownership significantly contributes to firms’ innovation output, indicating that cross-owners play the role of “collaborative governance.” While paying attention to the collusion effect of the cross-ownership, they shall not ignore its governance effect, for example, the promotion effect on the innovation level. Government regulators should appropriately supervise the cross-ownership linkage, which is conducive to maintaining the market order and driving the healthy development of the capital market.
Maximizing research impact: strategies for securing competitive funding in research and development centers
Authors: Ferrús-Pérez Juana M. , Escribá-Esteve Alejandro , Perea-Vicente Jose-Luis
Published: November 2024

Purpose

This study analyzes the effectiveness of research and development (R&D) organizations’ strategies for obtaining competitive international funding and the role of research management offices (RMOs) in this process. It examines the internal factors that influence the proactivity and effectiveness of R&D centers and provides a theoretical model for improving the fundraising capacity and, ultimately, the competitiveness and sustainability of these institutions.

Design/methodology/approach

The study sample comprised Spanish public R&D centers in the health and biomedical sectors. Partial least squares were used in the analyses to ensure the robustness of the results.

Findings

Several independent variables showed a significant impact on the proactivity and effectiveness of R&D centers. The dispersed priorities of R&D managers reduce proactivity and fundraising effectiveness. Incentives and RMO workload increase proactivity, but workload alone also improves effectiveness.

Originality/value

This study focuses on the management of health and biomedical R&D centers. It examines the influence of internal factors, such as managerial priorities, RMO incentives and RMO workload, on competitive international funding. These findings have significant theoretical and practical implications for the development of internationally applicable management strategies to enhance the effectiveness of research funding acquisition.
Mental health challenges faced by foreign nurses: a scoping review
Authors: Efendi Ferry , Hadisuyatmana Setho , Malik Gulzar , Ramdani Wawan Febri , Has Eka Mishbahatul Mar’ah , Erfina Erfina , Mamnuah Mamnuah
Published: November 2024

Purpose

Foreign nurses encounter various challenges that impact their mental health, but there is a lack of comprehensive evidence on these difficulties and the strategies to address them. This study aims to synthesize the available evidence to identify these challenges and the strategies to support foreign nurses.

Design/methodology/approach

A scoping review framework was used with an exploration of seven databases (CINAHL, Embase, MEDLINE, PsycINFO, Web of Science, PubMed and ProQuest Central) to search for primary studies. Quantitative, qualitative and mixed-methods research were considered for inclusion, with manual searches of reference lists for potential additions. Studies published between 2013 and September 2023, and written in English were considered for inclusion.

Findings

About 22 of 1,077 identified studies were finally included in this review. Three distinct themes were identified as contributors to the nurses’ mental health challenges, and one theme emerged to highlight strategies to overcome the challenges. These contributors included the influences of diverse cultures, dynamics within the work environment, language barriers, separation from family and friends, heavy workloads and pressures, disparities in health-care systems and experiences of discrimination. Strategies identified to overcome the challenges were at individual, organizational and policy levels to support foreign nurses in navigating and mitigating stressors.

Originality/value

This study highlights the importance of targeted interventions to assist foreign nurses in overcoming challenges that may affect their mental health and well-being. Moreover, strategic interventions are crucial to support them in addressing the barriers they faced.
Is driving an electric two-wheeler (E2W) safe? Analysing safety risk factors of E2W considering the quality and reliability criteria
Authors: Tarei Pradeep Kumar , Gangadhari Rajan Kumar , Gumte Kapil
Published: November 2024

Purpose

The purpose of this research is to identify and analyse the perceived risk factors affecting the safety of electric two-wheeler (E2W) riders in urban areas. Given the exponential growth of the global E2W market and the notable challenges offered by E2W vehicles as compared to electric cars, the study aims to propose a managerial framework, to increase the penetration of E2W in the emerging market, as a reliable, and sustainable mobility alternative.

Design/methodology/approach

The perceived risk factors of riding E2Ws are relatively scanty, especially in the context of emerging economies. A mixed-method research design is adopted to achieve the research objectives. Four expert groups are interviewed to identify crucial safety risk E2W factors. The grey-Delphi technique is used to confirm the applicability of the extracted risk factors in the Indian context. Next, the Grey-Decision-Making Trial and Evaluation Laboratory (DEMATEL) technique is employed to reveal the causal-prominence relationship among the perceived risk factors. The dominance and prominence scores are used to perform Cause and Effect analysis and estimate the triggering risk factors.

Findings

The finding of the study suggests that reckless adventurism, adverse road conditions, individual characteristics and distraction caused by using mobile phones, as the topmost triggering risk factors that impact the safety of E2Ws drivers. Similarly, reliability on battery performance low velocity and heavy traffic conditions are found to be some of the critical safety factors.

Practical implications

E2Ws are anticipated to represent the future of sustainable mobility in emerging nations. While they provide convenient and quick transportation for daily urban commutes, certain risk factors are contributing to increased accident rates. This research analyses these risk factors to offer a comprehensive view of driver and rider safety. Unlike conventional measures, it considers subjective quality and reliability parameters, such as battery performance and reckless adventurism. Identifying the most significant causal risk factors helps policymakers focus on the most prominent issues, thereby enhancing the adoption of E2Ws in emerging markets.

Originality/value

We have proposed an integrated framework that uses grey theory with Delphi and DEMATEL to analyse the safety risk factors of driving E2W vehicles considering the uncertainty. In addition, the amalgamation of Delphi and DEMATEL helps not only to identify the pertinent safety risk factors, but also bifurcate them into cause-and-effect groups considering the mutual relationship between them. The framework will enable practitioners and policymakers to design preventive strategies to minimize risk and boost the penetration of E2Ws in an emerging country, like India.
Political cycles, fiscal policy and capital flight in Africa
Authors: Mawutor John Kwaku Mensah , Adjasi Charles
Published: November 2024

Purpose

This paper examined the interactive role of Political Cycles on the relationship between Fiscal Policy and Capital Flight in Africa.

Design/methodology/approach

A two-step System Generalized Methods of Moment empirical estimator was employed. This study used data on 40 African countries from 2009 to 2018.

Findings

The findings revealed that the interaction between political structures and fiscal policy is positive and significant, indicating that fiscal policies during election periods or different regimes would increase capital flight. The study found that political cycles positively affect capital flight, indicating that election periods and possible government changes promote capital flight activities. The tension and volatile atmosphere characterizing election periods in most African countries cause investors to use all alternatives, including illegal systems, to fly funds to a potentially stable economy.

Practical implications

This study recommends that government and policymakers maintain fiscal discipline during election years and enact pragmatic policies to ensure the continuity of critical fiscal policies to promote business climate and economic stability, especially when there is a change in government.

Originality/value

This study contributes to capital flight literature in two forms. One, the study, to the best knowledge of the authors, is the first to proxy tax with corporate tax (a sound proxy for tax within the business space). Also, this study is the first to empirically show that elections worsen the effect of fiscal policy on capital flight in Africa.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-02-2024-0130
The impacts of digital and learning orientations on supply chain resilience
Authors: Lin Yong , Pang Gu , Duan Keru , Luo Jing , Wang Sen , Qu Jingwen
Published: November 2024

Purpose

This study quantitatively investigates the impacts of digital and learning orientations on supply chain resilience (SCR) and firm performance (FP), aiming to fill the gaps in understanding their specific impacts in the context of Industry 4.0 developments and supply chain disruptions.

Design/methodology/approach

This study utilized survey techniques and structural equation modelling (SEM) to gather and analyse data through a questionnaire based on a seven-point Likert scale. Hypotheses were formulated based on an extensive literature review and tested using Amos software.

Findings

The study confirms SCR’s significant impact on FP, aligning with existing research on resilience’s role in organizational competitiveness. This study uncovers the nuanced impacts of digital and learning orientations on SCR and FP. Internal digital orientation (DOI) positively impacts SCR, while external digital orientation (DOE) does not. Specific dimensions of learning orientation – shared vision (LOS), open-mindedness (LOO) and intraorganizational knowledge sharing (LOI) – enhance SCR, while commitment to learning (LOC) does not. SCR mediates the relationship between DOI and FP but not between DOE and FP.

Research limitations/implications

This research focuses on digital and learning orientations, recommending that future studies investigate other strategic orientations and examine the specific contributions of various digital technologies to SCR across diverse contexts.

Practical implications

The empirical findings emphasize the significance of developing internal digital capabilities and specific learning orientations to enhance SCR and FP, aligning these initiatives with resilience strategies.

Originality/value

This study advances knowledge by distinguishing the impacts of internal and external digital orientations and specific learning dimensions on SCR and FP, offering nuanced insights and empirical validation.
Assessing the impact of digital transformation capability for international market growth: the role of leadership support
Authors: Joshi Yatish , Chatterjee Sheshadri , Chaudhuri Ranjan , Shams S.M. Riad , Apostolidis Chrysostomos
Published: November 2024

Purpose

This study aims to examine the impact of an organization’s digital transformation capability (DTC) on its dynamic capabilities and strategic depth, which, in turn, could impact the organization’s international market growth (IMG). This study also investigates the moderating role of leadership support (LES) in using the DTC.

Design/methodology/approach

The study reviews various kinds of literature related to international marketing, dynamic capabilities, digital transformation, strategic marketing and LES. Following this, a dynamic capability view is adopted to develop a research model. This research model is later tested using partial least squares structure equation modeling with data from 385 respondents from different types of organizations.

Findings

The study demonstrates that an organization’s DTC significantly enhances its dynamic capabilities and strategic depth. LES is vital for effectively applying and leveraging DTCs since it influences the association between DTCs, competitive advantage and global marketing intelligence. The study also recognizes that strategic depth and dynamic capabilities contribute to IMG.

Research limitations/implications

The study uncovers the impacts of DTCs, influencing IMG. The study also provides valuable insights regarding the role of leadership in effectively leveraging the organization’s DTCs. It suggests the organization’s management should invest in improving DTC.

Originality/value

This study contributes to the prevailing literature on DTC, leadership and IMG. The study highlights the importance of DTC and how it impacts more established capabilities and leads to IMG of the organization. Further, this study is also unique as it establishes the importance of LES in leveraging the maximum benefits of the DTC.
Unveiling factors and contingencies influencing exhaustion in professional esports players: evidence from China
Authors: Liu Gordon , Meng-Lewis Yue , Wang Weiyue , Zhao Yupei
Published: November 2024

Purpose

The rapid growth of professional esports has highlighted the lack of a universally recognised governing body to standardise operations and competition rules. This absence presents many challenges. A key concern is the well-being of professional esports players (e-pro-players), who often suffer from exhaustion. This study aims to examine the factors contributing to exhaustion among e-pro-players.

Design/methodology/approach

Using the conservation of resources theory, we developed a framework to explain the factors leading to e-pro-players’ exhaustion and the conditions under which it occurs. We tested this framework with 126 responses in a dyadic survey from e-pro-players and their coaches in China. Additionally, we gathered qualitative insights from 50 interviews with esports stakeholders to provide more context for our quantitative findings.

Findings

Our study found that e-pro-players’ intrinsic motivation to engage in training reduces their exhaustion, while their struggle to cope with uncertainty in esports environments (intolerance of uncertainty) increases it. The effect of intrinsic motivation is weaker for those who believe their talent for playing esports is fixed (entity belief) but stronger for those with high relational identification with their coaches. Additionally, the link between uncertainty intolerance and exhaustion is stronger in players with strong entity beliefs.

Originality/value

Our study sheds light on the factors contributing to e-pro-players’ exhaustion within the partially regulated professional esports environment, a phenomenon that significantly influences their overall well-being. Through the identification and examination of these factors and the conditions under which they affect exhaustion, we deepen the understanding of the drivers of exhaustion for e-pro-players who operate in an industry lacking standardised regulations.
Recent developments in autonomous floor-cleaning robots: a review
Authors: Butaney Sarah , Gaurav Kumar , Ranjan Prabhat , Shrivas Nikhil Vivek
Published: November 2024

Purpose

Autonomous floor-cleaning robots (AFCRs) have become increasingly popular due to their ability to provide efficient and effective cleaning without the need for human intervention. These robots can perform various cleaning tasks, such as vacuum cleaning, mopping, scrubbing or sweeping, in domestic or industrial setups. As the use of floor-cleaning robots continues to grow, this paper aims to document key technological advancements.

Design/methodology/approach

The structure of the present work relies on published research articles excavated from general online research databases such as Google Scholar, Web of Science and Scopus. The authors use a variety of keywords and titles to search for research papers. Finally, 93 research articles are selected for review based on abstracts and key results that match AFCRs.

Findings

According to market trends, floor-cleaning robots dominate other cleaning areas. This review mainly focuses on five attributes of floor-cleaning robots: design and development of AFCR, complete coverage path planning, the application of machine learning (ML)/deep learning (DL), optimisation strategies for qualitative output and ethnographic studies. It also consists of discussions based on the results of reported technical works. Hence, AFCRs have dominated the market in the past decade and are likely to be more aggressive in the coming years.

Originality/value

To the best of the authors’ knowledge, only a survey article based on US-granted patents published in 2013 constitutes a review work in the research domain on AFCRs. In 2021, another review conducted a survey on the latest technological advancements in window-cleaning robots. It reviewed in detail the locomotion aspects, control mechanisms, adhesion mechanisms, sensors and actuators required for window-cleaning robots. In 2019, a comprehensive review was published on cleaning robots from a control strategy perspective for domestic applications. Therefore, the authors have crafted this review to understand the evolution of floor-cleaning robots in the past decade.
Sustainability outcomes of volunteer tourism in rural communities: empowerment and the role of volunteer tourism organizations
Authors: Tran Tuan Nien , Tran Thuong Ho Thuong
Published: November 2024

Purpose

Research on the sustainability outcomes of volunteer tourism (VT) in rural communities is rare. Drawing on the perspectives and theoretical concepts related to multiple forms of capital, empowerment, and sustainability, this paper presents the sustainability outcomes of VT and the role of empowerment and volunteer tourism organizations (VTOs) in attaining greater sustainability.

Design/methodology/approach

A total of 37 semi-structured interviews and 4 documents were conducted with stakeholders on the perceived socio-cultural impacts of VT on two farm communities in Vietnam. A qualitative thematic coding analysis was used to identify themes that explain the sustainability outcomes of VT.

Findings

The results of this study were divided into the nine themes of relationships, community resource development, job opportunities, educational effects, cultural exchanges, health, awareness of environmental conservation, physical changes, and promoting local products and tourism.

Practical implications

VTOs should involve the local community in the decision-making process for volunteer activities. It is essential to share their voices and concerns about how the VT is set up to ensure that they meet the community’s expectations. Moreover, the government can act as a bridge between VTOs and host communities, providing training and support services to locals after volunteers leave.

Originality/value

This research creates a model for connecting the sustainability outcomes of VT, empowerment, and the role of VTOs.
Integrated reporting business models and the role of presentation format: insight from an eye tracking study
Authors: Steenkamp Natasja , Fisher Richard
Published: November 2024

Purpose

The integrated reporting framework affords considerable discretion over the form and content of business model disclosures, but a diagrammatic representation is favoured. In practice, most firms choose to use an infographic. This study aims to determine whether an infographic is a more effective and efficient form of communication than narrative-only information. Additionally, the mediating role of psychophysiological arousal is examined.

Design/methodology/approach

Using an explorative experimental design, this study uses eye-tracking technology to examine how users interact with different presentation formats for business model disclosures and how this affects the effectiveness and efficiency of the disclosures. Using pupillometry, the impacts of presentation format on arousal are also examined, in addition to the mediating effect of arousal on recall and comprehension.

Findings

Infographic presentation led to a substantial decrease in reading time coupled with moderately lower recall relative to narrative-only presentation. However, no significant difference in comprehension was observed. Additionally, infographic presentation was associated with higher arousal, but arousal was not found to mediate the relationship between presentation format and communicative effectiveness.

Originality/value

The study assists reporters and standard-setters, such as the International Accounting Standards Board and International Sustainability Standards Board, by providing qualified support for the diagrammatic representations of business models as an efficient means of communicating complex financial and non-financial information and highlighting future research opportunities.
Drivers of brand love for organic wine brands: moderating role of ethnocentrism
Authors: Bhardwaj Seema , Adhikari Kishalay
Published: November 2024

Purpose

The consumption of organic wine has witnessed exponential growth, mainly because of changing lifestyles, rising disposable income, modernity aspects and claimed health benefits. Understanding the motivations and attributes affecting organic wine consumption (OWC) provides a limited perspective on consumption and behavioral patterns.

Design/methodology/approach

This study used a set of screening criteria to arrive at the final choice of fine-dining restaurants and bars that serve wine in their outlets. Based on the selected locations, we gathered responses from 558 consumers aged 18 years and above with prior experience of buying organic and non-organic wine. The hypothesized model was validated using covariance-based structural equation modeling (CB-SEM). From the perspective of organic wine consumption, the research findings exhibit significant links between the drivers.

Findings

The findings underscore the moderating impact of ethnocentrism toward shaping consumers’ attitudes and brand love. Additionally, gender and consumption frequency indicated significant variations among consumers of organic wine. Female consumers strongly believe that consumption of organic wine provides health benefits, societal acceptance and moments of joy. Additionally, men usually associate wine consumption with enhanced their affective, convivial and sensory pleasure.

Originality/value

This study examines the drivers and marketing outcomes of organic wine consumption using Behavioral Reasoning Theory (BRT) and the Theory of Hedonic Asymmetry (THA).
Performance evaluation of controlled low-strength blended cement concrete modified with recycled waste materials
Authors: Karthik M. , Oyebisi Solomon , Shakor Pshtiwan , Sharath Chandra Sathvik , Prajwal L. , Agrawal U.S.
Published: November 2024

Purpose

This work aims to investigate the feasibility of recycling waste plastic (polyethylene terephthalate) as a coarse aggregate for producing blended cement concrete modified with fly ash and pond ash.

Design/methodology/approach

The low, medium and high controlled strength blended cement concrete modified with varied proportions of fly and pond ashes were produced. Manufactured sand and recycled plastic coarse aggregate (RPCA) replaced normal fine and coarse aggregates. Concrete samples were tested for workability, mechanical and durability characteristics. Microstructural analysis was performed on cement concrete blended with fly and pond ashes and compared to conventional concrete samples.

Findings

All concrete mixes showed better flowability with values greater than 200 mm. Besides, the maximum flow time was approximately 8 s. The wet density of blended cement concrete-RPCA-based concretes was approximately 30% lower than that of conventional concrete. The compressive strengths of the controlled strength mix at 7 and 28 days were within the specified ranges. While the conventional concrete had slightly higher permeability, the blended cement concrete-RPCA-based concretes had better thermal resistivity and lower thermal conductivity. The scanning electron microscopy analysis revealed the densification of the microstructure due to the filler effects of fly and pond ashes.

Originality/value

This study establishes the prospects of substituting RPCA with normal coarse aggregate in the production of controlled low-strength blended cement concrete, offering benefits of structural fill concrete, lower permeability and thermal conductivity, higher thermal resistivity and reduced density and shrinkage.
Maximizing STEM resources for diplomats: A framework for speed, depth, and accuracy
Authors: Voth‐Gaeddert Lee E.
Published: November 2024

In the evolving landscape of science diplomacy, frontline diplomats increasingly rely on effective access to STEM knowledge to advance national interests and address global challenges. This paper presents a framework organizations can use for evaluating the approaches and tools available to their frontline diplomats, focusing on three key metrics: response time (speed), content depth and applicability, and consistency in accuracy. By evaluating tools via these metrics, the framework highlights the need for mechanisms that offer quick access to in‐depth and reliable STEM information, thus optimizing diplomatic effectiveness. The study provides examples from the US foreign affairs perspective within categories such as web searches, training programs, and consulting services, identifying opportunities for innovation and improvement. Identifying tools that maximize speed, depth, and accuracy, this framework aims to guide organizations in refining their resources, thereby equipping diplomats with the tools necessary to navigate complex, science‐driven global issues.
Microbiome and nutrient dynamics of organic manures for precision NPK management in sunflower (Helianthus annuus L.)
Authors: Joseph Babitha , Babu Subramanian
Published: November 2024

Organic manure plays an important role in soil fertility, microbial communities and sustainable agricultural strategies. In organic cultivation of crops, manures are mostly used without any calculation of the nutrients added to soil through their application. The quantities of nutrients supplied by the organic manures to the crop have to equalize the quantity of nutrients supplied by inorganic chemical fertilizers, in order to replace chemical fertilizers in organic farming. Since the organic manures release nutrients slowly into the soil over a period of time, the availability of nutrients to the standing crop requires precise estimation. In the present study, the amount of nutrients available in the soil as well as in all the manures was calculated. Moreover, the study included metagenomic analysis of different organic manures used by farmers and gives an insight to the role the microbiome plays in plant growth. Using a formula of STCR‐IPNS (soil test crop response integrated plant nutrition system), the quantities of different combinations of organic manures required to supply nitrogen, phosphorus and potassium (NPK) to sunflower plants were calculated. Organic manure combinations using animal bone meal, neem cake, farmyard manure and vermicompost recorded better growth and yield responses in sunflower plants compared to inorganic chemical fertilizers. Based on the estimation of NPK in the individual manures and in the soil, pot experiments were carried out to understand the effect of organic manures as well as inorganic fertilizers in the vegetative and reproductive growth of sunflower.
Hypoxia‐reduced YAP phosphorylation enhances expression of Mucin5AC in nasal epithelial cells of chronic rhinosinusitis with nasal polyps
Authors: Zhong Bing , Liu Jing , Ong Hsiao Hui , Du Jintao , Liu Feng , Liu Yafeng , Ba Luo , Sun Silu , Wang De Yun
Published: November 2024

Background

Chronic rhinosinusitis with nasal polyps (CRSwNP) is an upper respiratory disease characterized by persistent inflammation of the nasal mucosa. However, the mechanism of abnormal Mucin5AC expression by CRSwNP epithelial cells is not fully understood.

Objective

We investigated the potential role of yes‐associated protein (YAP) underlying the mechanism of excessive epithelial Mucin5AC expression in CRSwNP in a hypoxic model.

Methods

Tissue biopsies of CRSwNP (n = 60), chronic rhinosinusitis without nasal polyps (CRSsNP) (n = 9) and healthy controls (n = 30) were investigated together with a well‐established hypoxic model of primary human nasal epithelial cells (hNECs). The expression levels of hypoxia inducible factor (HIF)‐1α and YAP, and the effect of the signaling axis on mucus secretion in hNECs were analyzed.

Results

We observed a significant elevated expression levels of YAP in patients with CRSwNP and CRSsNP compared to controls. In addition, HIF‐1α expression of CRSwNP was higher than that of control group. Under hypoxic conditions, HIF‐1α was found to regulate the upregulation of YAP in hNECs. Further investigations revealed that HIF‐1α facilitated the activation and nuclear localization of active‐YAP by reducing the phosphorylation of YAP. This mechanism appeared to be linked to HIF‐1α‐mediated inhibition of LATS 1 phosphorylation and subsequent YAP degradation. HIF‐1α was shown to promote the expression of P63 and the levels of Mucin5AC in hNECs by enhancing YAP activation.

Conclusion

Our findings indicated that hypoxia enhances YAP activation by decreasing p‐LATS 1 and YAP phosphorylation. This has the potential to impact on the proliferation of basal cells and the differentiation of goblet cells in CRSwNP, ultimately leading to a pathological condition characterized by excessive Mucin5AC expression.