bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of High Targets in The Development of Infrastructure and Organizational Culture on Organizational Commitments to Employees and Performance
Authors: Budiwibowo Triyono , Komariyah Erna Fitri
Published: March 2024

This study provides evidence that achieving performance at high targets in infrastructure development requires an OCE and organizational culture. This study is driven by the high target for infrastructure development in Indonesia from 2015 to 2020 as a strategic policy to help support economic growth and fair distribution of social welfare. Multigroup Analysis assesses the moderating effects of the high target in infrastructure development and organizational culture. This result suggests that OCE has a positive impact on motivation, which subsequently has a significant impact on performance. Moreover, motivation has been shown to moderate the relationship between high targets and OCE. On the other hand, this finding shows that achieving high infrastructure development targets requires a strong organizational culture that will impact performance positively and significantly through increased motivation.
The Influence of Digital Literacy Levels on Social Media Use Among Students
Authors: Irene Janeth Gabriella , Andiyansari Popi
Published: March 2024

The level of internet penetration and contribution in Indonesia is on the island of Java; the penetration rate is 81.83%, and the contribution rate is 58.51%. Of these internet users, the majority of users are university students (S1/S2). Previous research explained the influence of Facebook social media on deviant teenage behaviour (cyberbullying). The method used in this study is quantitative with a correlational approach because it demonstrates the relationship between variables. The sample of this study included 200 students from Yogyakarta. Hypothesis testing using a t-test is performed to determine the results of the predetermined hypotheses. The t-test results show that in this study, there is a significant influence between digital literacy level and social media use.
Recycling in Islamic Perspective Case Study of Architectural Works Using Waste Building Materials
Authors: Yolandita Aristawati  , Hanif Budiman  , Putu Ayu P. Agustiananda  , Noram Irwan Ramli
Published: March 2024

Waste is a serious environmental problem worldwide. Waste can refer to various types of materials or substances resulting from human, industrial, agricultural and other activities. The waste problem covers aspects such as management, environmental impact and human health. In this paper, an Islamic perspective on waste recycling in building architecture is discussed. Case studies involving architectural works with the use of building waste reflect the principle of recycling in practice. Waste buildings are materials or structures which have been retired for their original purpose but which still have the potential to be reused with little or no major alterations. Architectural works such as households, community facilities, or even commercial buildings can use used materials that are still usable to reduce demand for new resources. However, in implementing the recycling concept in architecture, it is necessary to pay attention to several aspects, such as structural safety, quality of used materials, and compatibility with the surrounding environment. Islam encourages the use of resources wisely and in moderation, as well as minimizing negative impacts on the environment. This is the responsibility of humans as caliphs on earth to preserve the environment and to maintain the balance of the ecosystem. as well as compatibility with the surrounding environment. Islam encourages the use of resources wisely and in moderation, as well as minimizing negative impacts on the environment. This is the responsibility of humans as caliphs on earth to preserve the environment and to maintain the balance of the ecosystem. as well as compatibility with the surrounding environment. Islam encourages the use of resources wisely and in moderation, as well as minimizing negative impacts on the environment. This is the responsibility of humans as caliphs on earth to preserve the environment and to maintain the balance of the ecosystem.

Keywords: Islamic Perspective; Architecture; Recycle; Building material; Environmental Conservation
The Interplay Between Brain Lesions and Painter´s Creative Transformations
Authors: Da Mota Gomes Marleide
Published: March 2024

This narrative review addresses the complex relationship between neurological diseases and artistic expression, which can have a profound impact on a painter´s works. This exploration highlights the dynamic and ever-evolving connection between neuroscience and art, offering insights into the extraordinary ways in which the human brain and artistic expression intersect and evolve. Following brain damage, there may be the emergence of sudden artistic talents, intriguing changes in the styles of established artists, the paradoxical facilitation of artistic abilities despite the cognitive decline consequent to these injuries, besides coping strategies that artists adopt in response to the challenges of health. Therefore, this article investigates different scenarios where brain injuries and disorders have had a profound impact on artists, leading to the emergence of new talents, changes in artistic styles, and unexpected improvements in their work, as well as adaptations in their artistic practices, as represented by some painters such as Tommy McHugh (1949 -2012), Francisco Goya (1746-1828), Otto Dix (1891-1969), Willem de Kooning (1904-1997), William Charles Utermohlen (1933-2007) and Charles Meryon (1821-1868). Consequently, works of art can be valuable but understudied tools for understanding brain dysfunction, although they must be interpreted with great care.
Prevalencia de hipertensión arterial en pacientes jóvenes de una unidad de medicina familiar
Authors: Rodríguez Ayut Hernández , Estrada Yurixhi Cancino , Flores Laura Miriam Pérez
Published: March 2024

Introducción: La hipertensión arterial es una de las principales patologías a nivel mundial está cada vez se ha presentado en grupos de edades más jóvenes lo que repercute la funcionalidad y calidad de vida, es de suma importancia conocer la prevalencia de estos pacientes para disminuir la morbilidad y planear medidas de prevención e intervención. Objetivos: Conocer la prevalencia de la hipertensión arterial en adultos jóvenes de la unidad de medicina familiar N.80, de Morelia, Michoacán, México, Metodología: Estudio transversal, descriptivo, retrospectivo, en pacientes de 15 a 29 años, derechohabientes de la Unidad de Medicina Familiar 80, para determinar la prevalencia de hipertensión arterial. La obtención de la tensión arterial se realizó mediante el uso del expediente clínico, considerando como hipertensión arterial a aquellos pacientes que cumplieron con los criterios diagnósticos de HAS del Comité Nacional Conjunto de los Estados Unidos de América. El registro se llevó a cabo en el paquete estadístico (SPSS Ver.23.0) Datos presentados en porcentajes, Chi cuadrada para asociación de variables. Significancia estadística p menor de 0.05. Resultados: Se estudiaron 100 pacientes, de los cuales predomino el sexo femenino con 86% y de menor cantidad el masculino con 14%, dando como resultado que, el 9% de los pacientes son portadores de hipertensión arterial, 5% mujeres y 4% hombres. Conclusiones: La prevalencia de hipertensión arterial sistémica fue mayor en pacientes con sobrepeso y obesidad al igual que en aquellos participantes pertenecientes al género femenino, además a mayor edad la prevalencia de HAS también se incrementa.
Relevance of Inclusive Finance with Sustainable Development Goals (SDGs) Perspective of Maqashid Sharia
Authors:   Fakultas Ekonomi dan Bisnis Islam IAIN Syekh Nurjati Ciebon, Indonesia Jl Perjuangan By pass Cirebon Jawa Barat 45135, Rokhlinasari Sri , Widagdo Ridwan ,   Fakultas Ekonomi dan Bisnis Islam IAIN Syekh Nurjati Ciebon, Indonesia Jl Perjuangan By pass Cirebon Jawa Barat 45135
Published: March 2024

This research aims to find out the right financing scheme so that the implementation of SDGs is more optimal and beneficial for small communities. inclusive financial contributions (zakat, infak and alms) in realizing SDGs and their relevance in realizing SDGs from a sharia maqashid perspective. This study uses a combination of qualitative-quantitative methods and approaches. Quantitative data analysis used is a method of tabulation, composing coding and score of variables. While qualitative data analysis includes the stage of data reduction, presentation and withdrawal of conclusions The results of this study show that the implementation of SDGs is carried out by a joint financing scheme through government and non-government budgets, one of which is through the distribution of zakat. The contribution of zakat in the implementation of SDGs has been carried out by the National Zakat Agency (Baznas) in the form of independence programs, religious education, health and social care. The relevance of zakat in realizing SDGs with Sharia Maqashid is shown in aid programs organized by Baznas such as the Program (1) eliminating poverty, (2) ending hunger, (3) good health and well-being, (4) quality education, and (5) clean water and sanitation relevant to the SDGs Program.
The Role of Leadership and Local Capital on Village Fund Management
Authors:   Universitas Diponegoro, Kushandajani Kushandajani
Published: March 2024

The enactment of Law no. 6/2014 in Indonesia has raised complex issues regarding the management of Village Fund. On one hand, Village Fund (local term: Dana Desa) gives hope for a more meaningful development in the village, but on the other hand the unpreparedness of human resources to manage the Village Fund has caused some problem. Therefore, the role of leadership and local capacity are parts of the solution to village fund management. Several important findings in the management of Village Fund were obtained using quantitative method as the main method in this research. First, the role of leader has a strong influence on planning, implementation, and performance of the program. Second, local leaders are required to have strong characters which can be a role model, fulfill promises, and work hard, and actively encourage ideas as well as providing social solutions for the community. Third, social capital as part of local capacity in the form of mutual cooperation (local term: gotong royong), caring, and mutual trust is able to survive in the village as part of the solution for Village Fund management.
Caracterização nutricional de farinhas de insetos com potencial de utilização na alimentação humana
Authors:   , Oliveira Lívya Alves
Published: March 2024

Diante de projeções de crescimento acelerado da população global, estima-se que a demanda mundial por proteínas deverá dobrar até o ano de 2050. Nesse cenário, questões sobre modos de produção de alimentos de qualidade e em quantidade suficiente tornam-se pautas contra o enfrentamento da insegurança alimentar e nutricional. O potencial de insetos comestíveis como novo ingrediente tem sido investigado como alternativa às fontes convencionais de proteínas. O objetivo deste estudo foi revisar sistematicamente estudos in vivo que avaliaram a qualidade proteica de insetos e desenvolver e caracterizar farinhas de insetos comestíveis (Tenebrio molitor, Gryllus assimilis, Belostoma anurum) com potencial de uso na alimentação humana. Para avaliar a influência do estágio de maturação no conteúdo nutricional dos insetos, as farinhas de Tenebrio molitor e Gryllus assimilis foram produzidas em dois estágios de desenvolvimento. As farinhas foram analisadas quanto a sua composição centesimal, conteúdo de minerais, atividade antioxidante, compostos fenólicos, carotenoides, vitaminas C e E, riboflavina, niacina, perfil de aminoácidos, digestibilidade proteica in vitro e solubilidade em função do pH. A partir da revisão sistemática, foi possível observar que, devido à alta heterogeneidade dos resultados não se pode concluir que os insetos apresentam alta qualidade proteica, embora tenham sido encontrados resultados positivos quanto ao valor biológico da proteína. As farinhas desenvolvidas mostraram-se fontes de proteínas, fósforo, cobre, ferro, zinco, manganês. As farinhas desenvolvidas a partir das três espécies atenderam às exigências de histidina, treonina, aminoácidos sulfurados e aminoácidos aromáticos, entretanto, a lisina foi o aminoácido limitante em suas composições. As proteínas das farinhas de Tenebrio molitor e Gryllus assimilis apresentaram boa digestibilidade e maior solubilidade em pH alcalino. O estágio de desenvolvimento dos insetos foi capaz de influenciar seu conteúdo nutricional, perfil de aminoácidos e propriedades funcionais da proteína, sendo o Gryllus assimilis adulto e a pupa de Tenebrio molitor com resultados superiores em relação às ninfas e larvas das respectivas espécies. Diante do exposto, a utilização de farinhas de insetos pode ser considerada pela indústria de alimentos com o objetivo de agregar valor nutricional a produtos e preparações. Palavras-chave: Entomofagia. Insetos comestíveis. Digestibilidade proteica. Aminoácidos. Compostos bioativos.
Recomendações para otimização da superestrutura de pontes em concreto protendido e pontes mistas de aço e concreto
Authors:   , Coelho Alvaro Carneiro
Published: March 2024

A otimização estrutural é crucial na engenharia civil, especialmente quando se trata de projetos de pontes tendo em vista o alto valor econômico dessas estruturas. O aumento do tráfego rodoviário tem aumentado a demanda de construção ou reparação das pontes já existentes, dessa forma, a busca por estruturas otimizadas vem se tornando cada vez mais frequente. Apesar de vários trabalhos existentes na literatura, a grande maioria busca a otimização sem considerar aspectos normativos de projeto. Dessa forma, esse estudo propõe uma abordagem abrangente, focada em pontes com longarinas pré-moldadas protendidas e pontes mistas de aço e concreto, incorporando todas as verificações normativas brasileiras. Foram modeladas 152 pontes via elementos finitos, abrangendo vãos de 20, 30 e 40 metros, variáveis como alturas, espaçamentos, larguras de balanço e espessuras de laje também foram consideradas. O estudo também explorou a influência do uso e da distância entre transversinas / diafragmas, bem como a resistência do concreto adotado (fck). A análise permitiu a geração de curvas correlacionando o consumo de armadura ativa, armadura passiva e consumo de concreto para o caso das pontes pré-moldadas protendidas e de aço estrutural e armadura passiva para as pontes mistas de aço e concreto, levando à determinação das alturas ideais para longarinas e lajes, além de espaçamentos e larguras otimizados. Esses resultados visam não apenas otimizar o consumo de materiais, mas também simplificar as fases de projeto e orçamentação de novas estruturas, promovendo eficiência e sustentabilidade no cenário de pontes. A abordagem integral do estudo, que vai além da simples otimização estrutural, destaca-se pela consideração de múltiplos parâmetros normativos, proporcionando uma contribuição significativa para a engenharia de pontes e estruturas. Palavras-chave: Otimização, pontes, pontes mistas, concreto protendido, aço.
Economic efficiency of Google’s main network services: prospects and benefits of application
Authors: Матыгов М.М. , Уматгериева Л.Р. , Магомадова З.С.
Published: March 2024

В статье проводится анализ основных сетевых сервисов компании Google с учетом их влияния на экономический сектор. Рассматриваются возможности и преимущества использования данных сервисов, выявляется их важность для экономики в целом. Подробное рассмотрение функционала и влияния Google-сервисов на бизнес-процессы позволяет выделить ключевые аспекты, способствующие экономическому развитию и эффективности предприятий. Современные информационные веб-технологии позволяют пользователям создавать и распространять собственный контент в сети Интернет. Данная технология обеспечивает комплексный подход к организации, внедрению и поддержке веб-ресурсов, особенностью которых является принцип вовлечения пользователей в совместное наполнение, редактирование и использование контента.

The article analyzes the main network services of Google, taking into account their impact on the economic sector. The possibilities and advantages of using these services are considered, revealing their importance for the economy as a whole. A detailed review of the functionality and impact of Google services on business processes allows us to identify key aspects that contribute to the economic development and efficiency of enterprises. Modern information web technologies allow users to create and distribute their own content on the Internet. This technology provides an integrated approach to the organization, implementation and support of web resources, the feature of which is the principle of involving users in the joint content, editing and use of content.
Violations of the rights of lawyers in the commission of official crimes
Authors: Соловьева Ю.И. , Смирнов А.М.
Published: March 2024

В статье актуализируется вопрос нарушений прав адвокатов. Отмечается, что существует проблема воспрепятствования законной адвокатской деятельности, которая наиболее отчетливо прослеживается при анализе уголовных дел о должностных преступлениях, потерпевшими по которым становятся адвокаты. Выявлены на основе анализа материалов судебной практики основные причины и мотивы таких деяний, а также сделан вывод о том, что адвокат становится жертвой преступления в результате своей профессиональной занятости, то есть относится к профессионально-виктимному типу жертв. Полагается, что мер государственной защиты адвокатов, закрепленных действующим законодательством, недостаточно для предотвращения преступлений в отношении них, в то время как эффективное выполнение адвокатами профессиональных задач возможно только при наличии действенного механизма защиты их прав на государственном уровне. Обосновывается необходимость укрепления правовых гарантий адвокатской деятельности.

The article updates the issue of violations of the rights of lawyers. It is concluded that there is a problem of obstruction of legitimate advocacy, which is most clearly seen in the analysis of criminal cases of official offenses, in which lawyers become victims. Based on the analysis of judicial practice materials, the main causes and motives of such acts are identified, and it is also concluded that a lawyer becomes a victim of a crime as a result of his professional employment, that is, he belongs to the professionally victimized type of victims. It is believed that the measures of state protection of lawyers, enshrined in current legislation, are insufficient to prevent crimes against them, while effective performance of professional tasks by lawyers is possible only if there is an effective mechanism for protecting their rights at the state level. The necessity of strengthening the legal guarantees of advocacy is substantiated.
Actual problems of fire training of police officers
Authors: Белевцев В.В.
Published: March 2024

В статье рассматриваются актуальные вопросы огневой подготовки сотрудников полиции. Отмечается, что сотрудникам полиции в профессиональной деятельности приходится применять огнестрельное оружие в ситуации самообороны, задержания преступника, освобождения заложников и при иных обстоятельствах, связанных с оперативной деятельностью. Аналитическая и теоретическая работа – необходимая часть подготовки, которая призвана облегчить и упростить процесс обучения. Задача преподавательского состава кафедры огневой подготовки в образовательных организациях МВД России состоит в том, чтобы подготовить полицейских к реальной службе и жизненным ситуациям, которые кардинально отличаются от учебных.

The article deals with topical issues of fire training of police officers. It is noted that police officers in their professional activities have to use firearms in a situation of self-defense, detention of a criminal, release of hostages and under other circumstances related to operational activities. Analytical and theoretical work is a necessary part of training, which is designed to facilitate and simplify the learning process. The task of the teaching staff of the Department of Fire training in educational organizations of the Ministry of Internal Affairs of Russia is to prepare police officers for real service and life situations that are radically different from educational ones.
Responsibility for organizing activities to attract funds and (or) other property (Article 172.2 of the Criminal Code of the Russian Federation)
Authors: Санташов А.Л. , Миронов А.В. , Герасимова Е.В.
Published: March 2024

Федеральным законом от 30 марта 2016 года № 78-ФЗ «О внесении изменений в Уголовный кодекс Российской Федерации и статью 151 Уголовно-процессуального кодекса Российской Федерации» Уголовный кодекс Российской Федерации дополнен статьей об ответственности за организацию деятельности по привлечению денежных средств и (или) иного имущества. Авторами анализируется состав преступления, предусмотренный ст. 172.2 УК РФ. Выявляются соответствующие проблемы квалификации и технико-юридического конструирования данной уголовно-правовой нормы.

Federal Law No. 78-FZ of March 30, 2016 "On Amendments to the Criminal Code of the Russian Federation and Article 151 of the Code of Criminal Procedure of the Russian Federation" supplemented the Criminal Code of the Russian Federation with an article on responsibility for organizing activities to attract funds and (or) other property. The authors analyze the corpus delicti provided for in Article 172.2 of the Criminal Code of the Russian Federation. The relevant problems of qualification and technical and legal construction of this criminal law norm are identified.
Investigation of Anatomy of Zooplankton by DAPI, Nile Red and Phalloidin Staining
Authors: Tong Houyu , Huang Jingwen
Published: March 2024

The behavior of phototaxis is essential for the living of benthic and biofouling organisms, and it is also related closely with factors such as locomotion, sense of light and ecological niche. This experiment sought to find the correlation by analyzing and comparing body structure of some zooplanktons, these include eye structure, muscle, lipid, and fat distribution. In this experiment, samples of bryozoan (Bugula neritina) larvae, amphipod (Niphargus sp.), isopod (Cirolanidae sp.), and copepod (Harpacticoid sp.) were treated with three types of fluorescent stain, DAPI, Nile Red and iFour™448 Phalloidin. The result of the experiment showed that the advance eye structure in Amphipod (Niphargus sp.) and Isopod (Cirolanidae sp.) may allow them to identify color, shape and react to change in light condition faster than bryozoan (Bugula neritina) and copepod (Harpacticoid sp.) which bears simple eye structures. It was observed that more muscle fibers in of Amphipod (Niphargus sp.) and copepod (Harpacticoid sp.) may contribute to faster locomotion comparing to bryozoan (Bugula neritina) larvae. Beside these results, Nile Red signals also suggested the presence of microplastics inside some zooplankton specimens, indicating an environmental issue that can further influence the ecosystem and Human.
Hemiplegia Patients Hand Rehabilitation Robot
Authors: Liu Zongyuan
Published: March 2024

A hand rehabilitation robot (Medical training system) can be used for hemiplegia patients to recover hand joints’ movement and assist in bending or stretching of each finger. Through the control system, it realizes a variety of movement forms to help single or multiple fingers for rehabilitation treatment. This essay is divided into three main sections. The first section describes the pathology of hemiplegia, as well as the process of rehabilitation in Rehabilitation Medicine and the Hand Rehabilitation Robot that can be used to assist physicians in the rehabilitation process. In the second section, it experimentally ascertains the trajectory of hand movements, along with identifying the maximum and minimum achievable angles for each joint of the hand. In the third section, it shows the design process of the Hand Rehabilitation Robot. During this phase, particular attention is given to the design of the connection rod, aligning it with experimentally derived maximum and minimum measurements. This approach aims to optimize the rehabilitation effect. Simultaneously, the development of the electronic control system is undertaken, facilitating precise and accurate control over the robot's functionalities. Finally, through the experimental study, it verifies the feasibility and reliability and can basically meet the hemiplegic patient’s clinical rehabilitation needs.
The Role and Therapeutic Potential of α-secretase in Alzheimer’s Disease
Authors: Peddapalli Vandana , Van Oosten-hawle Patricia
Published: March 2024

Currently, more than six million Americans suffer from Alzheimer's Disease (AD), a number that is set to become 12.7 million by 2050. But despite killing more people than breast cancer and prostate cancer combined, there are no available pharmaceuticals that can cure AD, halt its pathogenesis, or reverse its effects. Therefore, the need for a thorough understanding of the physiological mechanisms behind AD progression has captured the attention of countless researchers and clinicians worldwide. In the last 30 years alone, the scientific community has made unprecedented progress towards an effective therapeutic. Notably, the amyloid cascade hypothesis has been one of the most dominating theories in recent AD research and drug discovery. The hypothesis suggests that AD’s main trigger lies in the accumulation of amyloid-beta protein fragments within brain tissue. Here, I present a review of some of the latest efforts to inhibit the production of these neurotoxic amyloid-beta peptides through the modulation of α-secretase enzyme activity in APP proteolysis.
A Critical Review of the Inheritance of Mitochondrial DNA in Humans
Authors: Malinowska Zuzanna
Published: March 2024

The dogma of mitochondrial inheritance states that mitochondrial DNA (mtDNA) is inherited solely down the maternal line. Traditionally, the elimination of paternal mtDNA happens through various mechanisms. Elimination mechanisms such as autophagy degradation or endonuclease G (EndoG) degradation have been widely studied in model organisms, while ubiquitin-mediated elimination has been identified in mammals and humans. Despite the existence of several research papers that support maternal inheritance, a controversial 2018 research paper by Luo et al. counters this longstanding dogma and proposes biparental inheritance of mtDNA. Since its publication, multiple studies have tried to justify this transmission through nuclear-mitochondrial DNA (NUMTs) or nuclear mtDNA concatemers (mega-NUMTs). It has been established that the phenomenon of biparental inheritance is not frequent since maternal inheritance entirely dominates over paternal transmission in the evolutionary timescale. This review explores the research linked with mitochondrial elimination and mitochondrial transmission, showing that further research is required to thoroughly understand this area of genetics.
Solar-Powered Electric Vehicle Charging Infrastructure
Authors: Abdula Amil , Wells Sean
Published: March 2024

As vehicles continue to dominate the transportation industry, serious questions are being raised as to the environmental harm caused by internal combustion engine (ICE) powered vehicles. Recently, there has been a surge in the popularity of electric vehicles (EVs) as a supposedly less damaging alternative to ICEs. While some studies have shown that EVs can be more harmful to the environment due to the emissions in their production and electricity generation, there are aspects that have the potential to be improved. Solar power has emerged as a viable option, as it is available reliably in most locations and can be placed in various locations. More specifically, in order to maximize EV adoption by increasing infrastructure, an everyday location, such as a school. However, solar panels do have several variables that affect their exposure to sunlight. Since the angle of installation can be readily controlled, a solar panel apparatus was set up to figure out the most effective angle for power generation. This solar panel data, in conjunction with local vehicle data, school parking lot data, and school roof data, is used to generate an infrastructure plan for the school of study. The findings conclude that the solar panels required to power the 11 EV chargers calculated to be appropriate for current demand would cover about 5,469 square feet. The calculation of these numbers not only proves the feasibility of such an infrastructure plan but also the relatively unobstructive nature of the infrastructure, further highlighting its practical application.
Novel Diagnostic Methods for Endometriosis
Authors: Tejeswi Anushka
Published: March 2024

Endometriosis is a detrimental disease that affects millions of women globally often resulting in symptoms as serious as infertility. While this disease is so prevalent, limited research and funding in search of diagnostic methods exists to this day. Currently, the gold standard for diagnosing endometriosis is through an extremely invasive surgery called a laparoscopy. As many women do not want to go through with this surgery it leads to countless women around the world unaware of the fact that they possess this disease.  This paper intends to evaluate the accuracy and effectiveness of emerging diagnostic techniques such as biomarkers, imaging modalities, and additional tests for the early detection and diagnosis of endometriosis. Through a comprehensive literature review and examining existing studies, this paper aims to highlight the positives and negatives of various diagnostic methods in order to replace the gold standard invasive laparoscopy surgery. By evaluating these various diagnostic techniques, the use of biomarkers and targeting miRNA cells proved to be more promising for future diagnosis of endometriosis. They were cost-effective, reliable, and non-invasive. The other diagnostic methods were somewhat favorable however they lacked enough research and reliability. Through these evaluations, it is able to be seen that there are additional methods for diagnosing endometriosis which are far less invasive. More money and research is required in the field of endometriosis and women’s health, in general, to acquire FDA funding for these methods and allow for fewer women globally to suffer from the painful side effects of this harmful disease.
Alzheimer’s Disease: A Comprehensive Review of its Causes, Diagnosis, and Treatment
Authors: Prabhu Anirudh
Published: March 2024

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that results in the loss of memory, motor function, ability to think, and other basic functions required for day-to-day life. The causes of the disease are still being investigated, but scientists and researchers have mostly agreed on one of the major genetic contributions to the disease. The excess buildup of two proteins, Tau and β-amyloid, limits communication between nerve cells or neurons. The buildup of these proteins only increases with the progression of the disease. This paper will discuss the genetic causes of AD, the process behind the formation of neurofibrillary tangles and amyloid plaques, recent neuroimaging techniques that help diagnose the disease, current symptomatic treatments, and upcoming future treatments that may be able to slow the progression of the disease significantly.
The Deterioration of the Human Genome Through Mutation Accumulation
Authors: Spasic Katja , Camara Hawa
Published: March 2024

Mutations are held inside the human genome, which serves as an instruction manual for our body. The genome contains our total genetic parts, including our nucleotides, chromosomes, genes, DNA, and RNA. With the human mutation rate displaying a directly proportional relationship to each generation, concern has arisen amongst biologists. When looking at the continued accumulation of mutations, one could expect progressive decay within every function of humanity. However, the Primary Axiom would not be able to arise from this perspective. The Primary Axiom is an idea shaped by Neo-Darwinism, which states that the human race was born from one initial genome after a series of mutations and natural selection. In this paper we will review the deleterious nature of mutations and the continued deterioration of the human genome since its inception. I will start by explaining the effects of the continued accumulation of various mutations, and go on to address the process of natural selection.
Moldova Köztársaság a forrongó 2024-es évben
Authors: Barabás T. János
Published: March 2024

Elemzésemben Moldova Köztársaság nyugati irányú, bonyolult és akadályokkal teli felzárkózási folyamatát vizsgálom. A jelenlegi elnök, az EU-párti Maia Sandu az egyetlen politikus, aki nem titkolja indulási szándékát az őszi államfői választáson. Fő ellenjelöltjei olyan politikai szereplők, akik nem tagadták meg oroszbarát szimpátiájukat (a szocialista Igor Dodon), vagy akikről feltételezhető, hogy továbbra is fenntartanák kapcsolataikat Oroszországgal – mint Ion Ceban, a főváros polgármestere és Irina Vlah, a gagauz autonómia volt kormányzója. A moldovai elnökválasztásnak az ukrajnai háború miatt ezúttal regionális fontossága is lesz. Az EU belső zavarai gyengíthetik az Unió Kelet-Európa politikáját, tovább fokozva Moldova belpolitikai gondjait. A januári kétoldalú miniszterelnöki találkozón a magyar fél biztosította moldáv partnerét kiemelt támogatásunkról uniós integrációjában, így legalább nyugati régiójában biztonságos Moldova sorsa.
Contribuţii la istoria familiei Balş în secolul al XVIII-lea – începutul secolului al XIX-lea,
după testamente şi foi de zestre
Authors: ZAHARIUC Petronel
Published: March 2024

Despite appearances, the history of the Balş family, one of the most important families of
medieval and modern Moldavia, still offers historians a rich field of work. With this article,
which starts from the Balş Family Register ("Condica de la Dumbrăveni"), which was the
basis for the family tree of 1813, I shed some light on the history of the Balş family in the
18th and early 19th centuries and publish some of the unknown documents that
I considered most important (wills, dowry papers and estate divisions).
Ofensiva Brusilov: catalizator al negocierilor şi al intrării României în război? Câteva ipoteze istoriografice
Authors: BALAN Iana
Published: March 2024

General Alexei Brusilov’s offensive was one of the outstanding operations of the Russian
Army in the First World War. Through the novelty elements and the proposed strategic
operations, this operation provided study material for the following generations and stood
out with its innovative techniques. Its impact and results have brought positive opinions but
also criticism. From a fast and favorable start, it would lose its intensity and lead to
massive losses on the part of the Russians that would mark the Russian Army and bring a
new wave of criticism towards Tsar Nicholas II, who took over its leadership in the summer
of 1915. Among the discussions regarding the impact and effects of the Brusilov offensive
were also discussions related to its progress and Romania's entry into the war. Romanian,
Western, and Russian historians have come up with different hypotheses, and opinions are
divided. Some historians believe that the Brusilov offensive was a direct catalyst for the
negotiations and Bucharest’s final decision to enter the war. While other historians believe
that it played an insignificant role.
In fact, Bucharest’s decision to submit the declaration of war in Vienna was caused by
multiple factors. But the two years of neutrality and negotiations with the Entente Powers
and the situation in August 1916 were much more complex than the Brusilov offensive,
which had already lost its intensity. In fact, in the general context, the allies had yielded
and were prone to yield to the Romanian cause. The situation at the front, the fear of the
collapse of the Austro-Hungarian army, and a separate peace with Vienna as a result of the
Brusilov offensive, which would have led to the loss of a reason for Romania’s intervention,
determined Romania's entry into the war.
Strategic interests and economic cooperation. The beginning of trade relations between Romania and Poland (1920-1921)
Authors: VIŢALARU Adrian
Published: March 2024

The study analyses the process of negotiation and ratification of the trade convention
between Romania and Poland, signed in Bucharest on 1 July 1921. As Romania and
Poland strengthened their political and military relations by signing the treaty of alliance
on 3 March 1921, a natural consequence was the strengthening of ties in the economic
field. This is why, shortly after the alliance was initialed, negotiations began between the
representatives of the two countries. Although the signing of the convention represented an
achievement in terms of the economic diplomacy of the two states, the document was only
ratified in April 1922 and entered into force in December 1922.
Pengaruh Pengembangan Karier, Disiplin Kerja, dan Lingkungan Kerja Fisik terhadap Kinerja Karyawan pada PT Murni Konstruksi Indonesia Palu
Authors: Meilani Tita , Muttaqin Ridlwan
Published: March 2024

The purpose of this research is to find out how career development, work discipline, and the physical work environment influence the performance of PT Murni Konstruksi Indonesia Palu employees. Multiple linear regression analysis was used, and the study population consisted of 30 employees. Employee performance is a dependent variable, and career development, work discipline, and physical work environment are independent variables. Observations and questionnaires were used to collect data. Various statistical techniques, such as partial hypothesis testing, simultaneous analysis, and coefficient of determination, are included in the data. Research findings show that employees' performance is positively and significantly influenced by career development, work discipline, and physical work environment. Apart from that, these three variables simultaneously positively and significantly influence employees' performance.
Pattern of Journalists’ Reportage of Security Issues in Anambra State, Nigeria, in 2023
Authors: Nnaemeka Obidike Frank , Ogunbadejo Samuel Idowu
Published: March 2024

Security in Anambra State in the Southeast geopolitical zone is a priority issue. This is because the free movement of people doing business and pursuing their goals, the prosperity and happiness of citizens, the freedom to go about achieving ones purposes is dependent on a secure State. Journalists on the other hand have a duty under their surveillance and correlation functions to provide news and information on the state of security within their areas of jurisdiction. It thus becomes imperative to evaluate the pattern of media reportage of security issues in Anambra State from the perspective of the journalists themslves. The objectives of the study were to; determine if security issues are well reported by the media in Awka, Anambra State, examine the slant of media reportage of security issues in terms of favour to some group, determine the basic challenges faced by the media in reportage of security issues and find out the level of cooperation between security agencies and journalists in the media reportage of security Issues.The study is anchored on Social Responsibility Theory and Framing Theory. It adopted a survey research approach and drew a sample size of 162 respondents based on census sampling. Questionnaire was the instrument for data collection. Major findings from the study reveal that journalists in Awka report security issues fairly well, that majority of the journalists do not slant their news, that fear was the basic among the challenges faced by the journalists in the reportage of security issues and that journalists in Awka do not have free access to the PPRO or DPO and other security agents in the State. Among others, the study recommended that media organisations, the security formations and the State government should pay careful attention to journalists in this sensitive and hazardous line of duty, that seminars and workshops involving journalists and security agents should also be organized from time to time in order to foster unity among journalists and security agents and government should also empower security agencies and journalists with requisite resources and motivation to do more in securing lives and property.
Indigenization
Authors: Pelletier Julie
Published: March 2024

Indigenization has described a process whereby First Peoples, Inuit and Metis have strategically adopted the term Indigenous as a sociopolitical identifier. Being Indigenous is complicated to define but includes being the first in a territory with the ties to the territory being of great cultural significance, being a distinct population, and having experienced colonial or other significant oppression affecting all aspects of life. Indigenization as a strategy focuses on asserting and supporting the core aspects of identity while pushing for recognition of inherent sovereignty and rights as First Peoples.  Efforts in Indigenization, such as decolonization of non-indigenous practices and institutions, are having effects in some nations while meeting resistance in others.
Editorial
Authors: Piedimonte Fabián C.
Published: March 2024

Estimados Lectores,

Desde sus inicios la Federación Latinoamericana de Asociaciones para el Estudio del Dolor (FEDELAT) se ha focalizado, entre otras cosas, en la actualización y difusión de los conceptos de dolor de utilidad en la práctica cotidiana de los profesionales de América Latina que diariamente batallan contra este flagelo universal.En este sentido, en el año 2009 recayó en el Dr. Edward Rabah la responsabilidad de la confección de las primeras Guías de Dolor de FEDELAT con una masiva y positiva repercusión en la comunidad médica de la región, demostrando su utilidad práctica.El vertiginoso progreso en los últimos años acerca de los conocimientos sobre el diagnóstico y tratamiento del dolor estimuló a FEDELAT a emprender a fines del año pasado, la elaboración de la “Guía FEDELAT para el manejo de los cuadros habituales de dolor en la práctica clínica en Latinoamérica”.
Academic citizenship and a world in crisis
Authors: Carney Stephen
Published: March 2024

In this paper I consider how the university might contribute to a regenerated commons. I discuss the problems of global citizenship as a heuristic, putting in its place, Appiah’s notion of cosmopolitanism to describe the Global Humanities bachelor program at my own higher education institution—Roskilde University in Denmark. I then consider the academic citizen as one participating in a space of dialogue and exchange where differences are recognized and the world is read through the lens of pluralism rather than over-confident and singular commitments to social justice, human rights or some idealized commons that threatens yet another dominant/dominating worldview. I end the paper with a reflection on the theme of hopelessness—viewing universities as central to creating academic citizens geared to the logic of deficit-thinking, endless development and abstract progress. Rather than trying to overcome hopelessness, we might be better advised to embrace it as one aspect of a broad and inclusive humanistic imagination; one where there are many knowledges but where most will not be encountered, and where there are no simple solutions
Comparison of Parkin Score and New Ballard Score for Gestational Age Assessment in Newborns with Ultrasound Scan as the Standard Reference
Authors: Sohail Shahzad  , Umar Nawaz Khan  , Shaheen  , Itrat Fatima  , Taqi Hasan  , Wajeeha Amber
Published: March 2024

Objective: To compare the assessment of gestational age (GA) in newborns using the Parkin Scoring and the New Ballard Scoring methods with the Ultrasound Scan Method as the Standard Reference, conducted at a peripheral military setup.

Methodology: A descriptive, cross-sectional study was conducted at the Pediatrics department of Combined Military Hospital (CMH), Abbottabad from July 2019 to June 2020. A total of 102 newborns were recruited from the CMH Nursery. GA was assessed using ultrasound scan, Parkin Score (PS), and the New Ballard Score (NBS). Pearson correlation coefficient statistics were calculated to evaluate the strength of associations among the three methods. The significance level (p value) was set at 0.05.

Results: The study included 47 (46.1%) females and 55 (53.9%) males. The highest GA (days) was calculated by ultrasound scan (268.76 ± 0.83), followed by PS GA (266.65 ± 1.00) and NBS (264.38 ± 1.05). There was no significant difference in GA assessment between PS and the ultrasound scan (2.32 ± 1.37 days; p = 0.208). The GA assessment between NBS and the ultrasound scan was found to be significant (4.38 ± 1.37 days; p = 0.004). However, this difference is not clinically significant. The NBS and PS GA assessment had a strong positive correlation (Pearson Coefficient = 0.80).

Conclusions: The PS is a reliable method for assessing GA in newborns and is comparable to the NBS. Further research with a larger sample size should be conducted to validate these findings.
Anti-Diabetic Effect of Okara Noodles on Streptozotocin-Nicotinamide Induced Diabetic Rats
Authors: Lesa Kaisun Nesa , Ahmad Nazir , Mayangsari Yunika , Cahyanto Muhammad Nur , Saputra Wahyu Dwi
Published: March 2024

Okara is a by-product of soybean curd residue resulting from the processing of soy milk and tofu. Okara noodles were made from wheat flour (WF) and okara flour (OF) with a few modifications that consist of high dietary fiber. Therefore, okara can be considered as an effective functional component with health-promoting benefits, especially for diabetes mellitus. Albeit, the anti-diabetic effect has not been conscientiously investigated. The goal of the current research was to evaluate the anti-diabetic effect of okara noodles on Streptozotocin-Nicotinamide induced diabetes mellitus rats. In the experiment, the different ratios of OF was used to prepared 3 formulated noodles (F0, F1 and F2) where F0 (0 % OF; 100 % WF), F1 (25 % OF; 75 % WF) and F2 (45 % OF; 55 % WF). Twenty-four male wistar rats were randomly divided into 4 groups (6 rats/groups), normal group of rats fed with standard feed and 3 diabetics groups, respectively fed with standard feed and formulated noodles variety (F0, F1 and F2). In in vivo analysis, it indicated, diabetes mellitus rats fed okara noodles had lower blood glucose levels and HOMA-IR and higher serum insulin levels and HOMA-b index than those fed control noodles (F0) as well as body weight managing activity. These outcomes demonstrated okara noodles possess significant anti-diabetic activity, prompting the applicability of okara noodles as potential food for the diabetes mellitus food products.
HIGHLIGHTS

Diabetes mellitus (DM) rats fed okara noodles had lower BGLs and HOMA-IR
DM rats fed okara noodles had higher serum insulin levels and HOMA-b index than those fed control noodles as well as body weight managing activity
Okara can be considered as an effective functional component for the anti-diabetic effect on STZ-NA induced DM rats

GRAPHICAL ABSTRACT