bluuebunny/crossref_metadata_2025 huggingface dataset:
National trends and perioperative outcomes of robotic oesophagectomy following induction chemoradiation therapy: a National Cancer Database propensity-matched analysis
Authors: Kamel Mohamed K , Sholi Adam N , Rahouma Mohamed , Harrison Sebron W , Lee Benjamin , Stiles Brendon M , Altorki Nasser K , Port Jeffrey L
Published: August 2020

OBJECTIVES

Oesophagectomy following induction chemoradiation therapy (CRT) is technically challenging. To date, little data exist to describe the feasibility of a robotic approach in this setting. In this study, we assessed national trends and outcomes of robotic oesophagectomy following induction CRT compared to the traditional open approach.

METHODS

The National Cancer Database was queried for patients who underwent oesophagectomy following induction CRT (2010–2014). Trends of robotic utilization were assessed by a Mantel–Haenszel test of trend. Propensity matching controlled for differences in age, gender, comorbidity, stage, histology and tumour location between the robotic and open groups. Overall survival was estimated by Kaplan–Meier analysis and compared by a log-rank test

RESULTS

Oesophagectomy following induction CRT was performed in 6958 patients. Of them, 555 patients (8%) underwent robotic surgery (5% converted to an open approach). Between 2010 and 2014, utilization of a robotic approach increased from 3% to 11% (Mantel–Haenszel, P < 0.001) and the number of hospitals performing at least 1 robotic oesophagectomy increased from 23 to 57. Compared to the traditional open approach, robotic oesophagectomy was used more frequently at academic hospitals (76% vs 60%, P < 0.001), and in patients living in metropolitan areas (85% vs 77%, P < 0.001) and those living in the Midwest (41% vs 33%, P < 0.001). In the matched groups, a robotic approach was associated with shorter median hospital stay (9 vs 10 days, P = 0.004) and dissection of more lymph nodes (median, 16 vs 12, P < 0.001). However, there were no differences in rates of positive margin resection (5% for both groups, P = 0.95), 30-day readmissions (5% vs 7%, P = 0.18), 30-day mortality (2.5% vs 4%, P = 0.79), 90-day mortality (9% vs 8.5%, P = 0.89) or 5-year overall survival (42% vs 39%, P = 0.19) between patients undergoing robotic and open surgery, respectively.

CONCLUSIONS

Robotic oesophagectomy after induction CRT is feasible and associated with shorter hospitalization compared to an open approach, and does not compromise the adequacy of oncological resection, perioperative outcomes or long-term survival.
Draft Genomes of Amaranthus tuberculatus, Amaranthus hybridus, and Amaranthus palmeri
Authors: Montgomery Jacob S , Giacomini Darci , Waithaka Bridgit , Lanz Christa , Murphy Brent P , Campe Ruth , Lerchl Jens , Landes Andreas , Gatzmann Fanny , Janssen Antoine , Antonise Rudie , Patterson Eric , Weigel Detlef , Tranel Patrick J
Published: August 2020

Amaranthus tuberculatus, Amaranthus hybridus, and Amaranthus palmeri are agronomically important weed species. Here, we present the most contiguous draft assemblies of these three species to date. We utilized a combination of Pacific Biosciences long-read sequencing and chromatin contact mapping information to assemble and order sequences of A. palmeri to near-chromosome-level resolution, with scaffold N50 of 20.1 Mb. To resolve the issues of heterozygosity and coassembly of alleles in diploid species, we adapted the trio binning approach to produce haplotype assemblies of A. tuberculatus and A. hybridus. This approach resulted in an improved assembly of A. tuberculatus, and the first genome assembly for A. hybridus, with contig N50s of 2.58 and 2.26 Mb, respectively. Species-specific transcriptomes and information from related species were used to predict transcripts within each assembly. Syntenic comparisons of these species and Amaranthus hypochondriacus identified sites of genomic rearrangement, including duplication and translocation, whereas genetic map construction within A. tuberculatus highlighted the need for further ordering of the A. hybridus and A. tuberculatus contigs. These multiple reference genomes will accelerate genomic studies in these species to further our understanding of weedy evolution within Amaranthus.
Older Latino Mental Health: A Complicated Picture
Authors: Jimenez Daniel E , Martinez Garza David , Cárdenas Verónica , Marquine María
Published: August 2020

The aggregation of Latino subgroups in national studies creates an overly simplistic narrative that Latinos are at lower risk of mental illness and that foreign nativity seems protective against mental illness (i.e., immigrant paradox). This broad generalization does not hold up as the Latino population ages. Given that social inequalities for risk appear to widen with age, the social disadvantages of being Latino in the United States increase the risk for mental illness across the life span. This review focuses on the mental health of older Latinos, specifically the 3 subgroups with the longest residential history in the United States—Mexicans, Puerto Ricans, and Cubans. We examine relevant epidemiological and clinical psychopathology studies on aging in these Latino populations and present evidence of the heterogeneity of the older Latino population living in the United States, thus illustrating a limitation in this field—combining Latino subgroups despite their diversity because of small sample sizes. We address the migration experience—how intraethnic differences and age of migration affect mental health—and discuss social support and discrimination as key risk and protective factors. We conclude with a discussion on meeting the mental health needs of older Latinos with a focus on prevention, a promising approach to addressing mental illness in older Latinos, and future directions for mental health research in this population. Success in this endeavor would yield a substantial reduction in the burden of late-life depression and anxiety and a positive public health impact.
A haplotype-resolved, de novo genome assembly for the wood tiger moth (Arctia plantaginis) through trio binning
Authors: Yen Eugenie C , McCarthy Shane A , Galarza Juan A , Generalovic Tomas N , Pelan Sarah , Nguyen Petr , Meier Joana I , Warren Ian A , Mappes Johanna , Durbin Richard , Jiggins Chris D
Published: August 2020

Background

Diploid genome assembly is typically impeded by heterozygosity because it introduces errors when haplotypes are collapsed into a consensus sequence. Trio binning offers an innovative solution that exploits heterozygosity for assembly. Short, parental reads are used to assign parental origin to long reads from their F1 offspring before assembly, enabling complete haplotype resolution. Trio binning could therefore provide an effective strategy for assembling highly heterozygous genomes, which are traditionally problematic, such as insect genomes. This includes the wood tiger moth (Arctia plantaginis), which is an evolutionary study system for warning colour polymorphism.

Findings

We produced a high-quality, haplotype-resolved assembly for Arctia plantaginis through trio binning. We sequenced a same-species family (F1 heterozygosity ~1.9%) and used parental Illumina reads to bin 99.98% of offspring Pacific Biosciences reads by parental origin, before assembling each haplotype separately and scaffolding with 10X linked reads. Both assemblies are contiguous (mean scaffold N50: 8.2 Mb) and complete (mean BUSCO completeness: 97.3%), with annotations and 31 chromosomes identified through karyotyping. We used the assembly to analyse genome-wide population structure and relationships between 40 wild resequenced individuals from 5 populations across Europe, revealing the Georgian population as the most genetically differentiated with the lowest genetic diversity.

Conclusions

We present the first invertebrate genome to be assembled via trio binning. This assembly is one of the highest quality genomes available for Lepidoptera, supporting trio binning as a potent strategy for assembling heterozygous genomes. Using our assembly, we provide genomic insights into the geographic population structure of A. plantaginis.
Humidity related magnetite alteration in an experimental setup
Authors: Zhang Qi , Appel Erwin , Stanjek Helge , Byrne James M , Berthold Christoph , Sorwat Julian , Rösler Wolfgang , Seemann Timo
Published: August 2020

Low-temperature oxidation (LTO) of magnetite is an alteration process which occurs under normal atmospheric conditions, causing maghemitization. The use of magnetic properties as palaeoclimate proxies requires improved understanding of how humidity and temperature affect such processes. We exposed natural magnetite, with grain size ranging from <1 to ∼30 μm, to different humidity conditions at room temperature and 70 °C for 1 yr. Changes in room temperature setups were very minor, but in all 70 °C setups alteration was detected by magnetic and mineralogical properties. Lowering of the Verwey transition temperature (Tv) turned out to be the most sensitive indicator of LTO, and also lattice constants correlate well with the shift of Tv. Thermomagnetic curves and XRD-results indicate that LTO affects the entire volume of the particles rather than only surface layers. The sample exposed to high relative humidity (rH) >90  per cent at 70 °C showed the strongest degree of LTO with an increase of the oxidation degree by ∼3 per cent according to Tv, and it was the only setup where partial alteration to hematite was indicated by Mössbauer analysis. The sample with extremely dry conditions (rH of ∼5 per cent) at 70 °C, and the sample that was exposed to cycles of high and low humidity in 2-weeks alternation at 70 °C, both revealed a smaller degree of LTO. The smallest change of the high temperature setups was observed for the sample with intermediate rH of ∼13 per cent. The results suggest a non-linear sensitivity of magnetite alteration to humidity conditions, high humidity strongly favours alteration, but alteration is strongly reduced when extreme humidity alternates with dry conditions, suggesting an importance of seasonality in natural weathering.
3. Crime and punishment
Authors: Renzo Massimo
Published: August 2020

This chapter focuses on crime and punishment. Punishment involves the imposition of hardship or suffering on a supposed offender for a supposed crime, by a person or body who claims the authority to do so. Criminal punishment is problematic in at least three respects: it harms those who are punished; it also harms, indirectly, their families and friends; and it imposes significant costs on the rest of the political community. There are two strategies for the justification of punishment: instrumental and non-instrumental justifications. The instrumental strategy has been traditionally pursued by endorsing some version of consequentialism, the moral theory according to which the rightness or wrongness of a given conduct, practice, or rule depends only on its consequences. Non-instrumental justifications, on the other hand, have been traditionally defended by retributivist theories, according to which, wrongdoers deserve to suffer in proportion to the gravity of the wrong they have committed.
7. Toleration
Authors: Galeotti Anna Elisabetta
Published: August 2020

This chapter explores toleration, which enables the peaceful coexistence of conflicting views and ways of life within the same society. It originally emerged as the political solution to the religious wars that devastated Europe after the Reformation. Toleration as the suspension of political interference in the religious creeds of people was affirmed as the only way to stop the killings for the sake of eternal salvation. At its origin, toleration was patterned on a model of civil coexistence that implied a divide between political affairs and private matters. The contemporary debate on toleration consists of three approaches: moral, liberal, and critical. The moral analysis of toleration is mainly concerned with the definition and justification of toleration as a social and moral virtue; the liberal analysis is focused on toleration as a political principle; and critical political theory proposes toleration as recognition.
12. Sovereignty and Borders
Authors: Fine Sarah
Published: August 2020

This chapter looks at sovereignty. Sovereignty is often defined as ‘supreme authority within a territory’. Analyses of sovereignty often operate across three domains — conceptual, descriptive-explanatory, and normative — with a view to examining the idea of sovereignty and its place in the political landscape. Since World War II, there have been significant international developments designed to consolidate the promise of an international state system committed to the principle of state sovereignty, while tempering its risks and excesses. A major landmark was the adoption of the Universal Declaration of Human Rights (1948). These developments raise questions about what sovereignty is, does, and where its limits ought to lie. The chapter then considers borders. Borders vary in the degree to which they are peaceful or contested, fortified, open or closed, and selectively open and closed to whom and what.
13. War and Intervention
Authors: Frowe Helen
Published: August 2020

This chapter assesses war and intervention. Just war theorists share two beliefs: that wars can, at least in theory, sometimes be just, and that the fighting of war is governed by moral rules. Just war theory is usually divided into jus ad bellum, jus in bello, and jus post bellum. Jus ad bellum (justice prior to war) sets the conditions under which it is just to declare war. Jus in bello (justice during the war) sets the ‘rules of engagement’, governing the conduct of combatants during a conflict. Jus post bellum (justice after war) deals with topics like war reparations and punishment of aggression and had, until recently, received comparatively little attention in the just war literature. Meanwhile, pacifism and realism offer alternative approaches to the ethics of war.
14. The Environment
Authors: Caney Simon
Published: August 2020

This concluding chapter addresses the normative issues raised by the environment. The environment includes the earth's crust, soil, and natural resources; the atmosphere; all the earth's water; and the biosphere. Human activity has a profound impact on the environment. Indeed, many of the activities that humans engage in — activities which often serve important human interests and goals — result in environmental degradation. Persons depend on the environment in many ways: for their food, health, and for many of their goals in life. As such, humans face a problem when people impact on the environment to such an extent that it undercuts people's capacity to enjoy the standard of living to which they are entitled. Thus, a just account of the environment will take into account both the fact that people have legitimate interests which involve using the environment and the fact that there must be limits on people's environmental impacts.
Introduction to International Relations
Authors: Jackson Robert , Sørensen Georg , Møller Jørgen
Published: August 2020

Introduction to International Relations provides a concise introduction to the principal international relations theories, and explores how theory can be used to analyse contemporary issues. Readers are introduced to the most important theories, encompassing both classical and contemporary approaches and debates. Throughout the text, the chapters encourage readers to consider the strengths and weaknesses of the theories presented, and the major points of contention between them. In so doing, the text helps the reader to build a clear understanding of how major theoretical debates link up with each other, and how the structure of the discipline of international relations is established. The book places a strong emphasis throughout on the relationship between theory and practice, carefully explaining how theories organize and shape our view of the world. It also shows how a historical perspective can often refine theories and provide a frame of reference for contemporary problems of international relations. Topics include realism, liberalism, International Society, International Political Economy, social constructivism, post-positivism in international relations, and foreign policy. Each chapter ends by discussing how different theories have attempted to integrate or combine international and domestic factors in their explanatory frameworks. The final chapter is dedicated to key global issues and how theory can be used as a tool to analyse and interpret these issues. The text is accompanied by online resources, which include: short case studies, review questions, annotated web links, and a flashcard glossary.
1. Why Study IR?
Authors: Jackson Robert , Sørensen Georg , Møller Jørgen
Published: August 2020

Introduction to International Relations provides a concise introduction to the principal international relations theories, and explores how theory can be used to analyse contemporary issues. Readers are introduced to the most important theories, encompassing both classical and contemporary approaches and debates. Throughout the text, the chapters encourage readers to consider the strengths and weaknesses of the theories presented, and the major points of contention between them. In so doing, the text helps the reader to build a clear understanding of how major theoretical debates link up with each other, and how the structure of the discipline of international relations is established. The book places a strong emphasis throughout on the relationship between theory and practice, carefully explaining how theories organise and shape our view of the world. It also shows how a historical perspective can often refine theories and provide a frame of reference for contemporary problems of international relations. Topics include realism, liberalism, International Society, International Political Economy, social constructivism, post-positivism in international relations, and foreign policy. Each chapter ends by discussing how different theories have attempted to integrate or combine international and domestic factors in their explanatory frameworks. The final chapter is dedicated to key global issues and how theory can be used as a tool to analyse and interpret these issues. The text is accompanied by an Online Resource Centre, which includes: short case studies, review questions, annotated web links, and a flashcard glossary.
2. IR as an Academic Subject
Authors: Jackson Robert , Sørensen Georg , Møller Jørgen
Published: August 2020

This chapter examines how thinking about international relations (IR) has evolved since IR became an academic subject around the time of the First World War. The focus is on four established IR traditions: realism, liberalism, International Society, and International Political Economy (IPE). The chapter first considers three major debates that have arisen since IR became an academic subject at the end of the First World War: the first was between utopian liberalism and realism; the second between traditional approaches and behaviouralism; the third between neorealism/neoliberalism and neo-Marxism. There is an emerging fourth debate, that between established traditions and post-positivist alternatives. The chapter concludes with an analysis of alternative approaches that challenge the established traditions of IR, and with a discussion about criteria for good theory in IR.
3. Realism
Authors: Jackson Robert , Sørensen Georg , Møller Jørgen
Published: August 2020

This chapter examines the realist tradition in international relations (IR). It highlights an important dichotomy in realist thought between classical realism and contemporary realism, including strategic and structural approaches. After describing the elements of realism, the chapter discusses the international thought of three outstanding classical realists of the past: Thucydides, Niccolò Machiavelli, and Thomas Hobbes. It then analyses the classical realist thought of Hans J. Morgenthau, along with strategic realism, neorealism, and neoclassical realism. Special attention is devoted to the defensive realism of Kenneth Waltz and the offensive realism of John Mearsheimer. Furthermore, the chapter looks at the recent theoretical debate among realist IR scholars concerning the relevance of the balance of power concept and it shows that realists often disagree among themselves. The chapter concludes with an overview of the prospects for the realist tradition as a research programme in IR.
7. International Political Economy: Contemporary Debates
Authors: Jackson Robert , Sørensen Georg , Møller Jørgen
Published: August 2020

This chapter examines four important debates in International Political Economy (IPE). The first debate concerns power and the relationship between politics and economics, and more specifically whether politics is in charge of economics or whether it is the other way around. The second debate deals with development and underdevelopment in developing countries. The third debate is about the nature and extent of economic globalization, and currently takes places in a context of increasing inequality between and inside countries. The fourth and final debate pits the hard science American School of IPE against the more qualitative and normative British School of IPE.
10. Foreign Policy
Authors: Jackson Robert , Sørensen Georg , Møller Jørgen
Published: August 2020

This chapter examines theories and approaches involved in foreign policy analysis. Foreign policy analysis is concerned with the study of the management of external relations and activities of nation-states, as distinguished from their domestic policies. The chapter first explains the concept of foreign policy before discussing various approaches to foreign policy analysis. It then evaluates the arguments of major theories by using a ‘level-of-analysis’ approach that addresses the international system level, the nation-state level, and the level of the individual decision maker. It also presents a case-study on the Gulf War to illustrate how insights from various approaches to foreign policy analysis can be brought together. A note on foreign policy experts and ‘think tanks’ is included to highlight the extent of research on the subject which extends well beyond universities.
2. Realism
Authors: Glaser Charles L.
Published: August 2020

This chapter examines realism as a dominant explanation of why and how states have sought security. It first considers the basic features of realist theory, including its emphasis on the implications of international anarchy and the importance of power, before discussing major divisions within the realist family, along with their implications for states’ security policies and war. The most fundamental division is between structural realism and motivational realism. The chapter proceeds by looking at the debate between Kenneth Waltz’s structural realism, offensive realism, and defensive realism. In contrast to Waltz and offensive realism, defensive realism argues that the risks of competition can make cooperation a state’s best strategy. The chapter illustrates how these different arguments result in divergent predictions for how China’s continuing economic growth is likely to influence international security. It suggests that war is more likely when the offence-defence balance favours offence.
3. Liberalism and Liberal Internationalism
Authors: Morgan Patrick
Published: August 2020

This chapter examines the liberalist approach to the theory and practice of international politics. It begins with an overview of liberalism and liberal internationalism’s main characteristics, including how they overlap with, yet significantly depart from, the realist perspective. It then considers the major liberalist schools of thought, namely: commercial or economic liberalism, human rights liberalism, international organization or institutions liberalism, and democratic liberalism. The chapter explores how contemporary liberal internationalism is losing significant power and appeal because the major Western states of the world system are experiencing serious international and domestic difficulties. It closes by indicating that the Western liberal internationalist order will likely lose a sizable portion of its long standing international dominance, resulting in a more widely spread global security management arrangement among a larger number of major states.
8. Poststructural Insights: Making Subjects and Objects of Security
Authors: Beier J. Marshall
Published: August 2020

This poststructuralist chapter explores some unconventional questions about somewhat unconventional subjects for Security Studies, a field that has traditionally been more inclined to focus on states in its investigations. In particular, it examines concepts such as ‘acting subject(s)’, which concerns who or what is acting to produce security or insecurity; ‘agency’, which refers to the capacity to act; ‘subjecthood’, which suggests mastery of one’s own agency or the idea that actions are products of one’s autonomous choices; and referent object(s), which are whom or what we seek to make secure. The chapter also discusses ‘smart’ bombs and other advanced weapons of the so-called Revolution in Military Affairs (RMA) that moved into popular consciousness beginning with the 1991 Gulf War. Finally, it considers the role of children and Indigenous peoples both in security discourse and actual security practices.
9. Postcolonialism
Authors: Laffey Mark , Nadarajah Suthaharan
Published: August 2020

This chapter examines postcolonialism, a recent and increasingly influential set of positions and perspectives within the wider discipline of International Relations, and its implications for Security Studies. It first considers the genealogies of postcolonialism, tracing its emergence in a set of transnational debates about the mutually constitutive relations between knowledge and imperialism. It then discusses the standard account of world history as organized around Westphalian sovereignty which informs Security Studies and shows how postcolonialism puts it in question. It also explores the relationship between culture and imperialism according to postcolonialism; Subaltern Studies and its significance to postcolonialism; the concepts of Orientalism and Occidentalism; and how contrapuntal analysis enables a postcolonial critique of Security Studies. The chapter concludes by asking what it might mean to decolonize Security Studies and whether there can be a postcolonial Security Studies.
14. Regime Security
Authors: Krieg Andreas
Published: August 2020

This chapter focuses on regime security, the condition where governing elites are secure from violent challenges to their rule, and the unique insecurity dilemma facing many developing countries. The chapter shows that the insecurities that confront regimes in the developing world mostly emanate from internal rather than external threats and are linked to the inability or unwillingness of these regimes to provide security inclusively as a public good to local communities. This regime insecurity loop is explained by contrasting public and regime security, and how regimes in the developing world are trying to manage internal threats through accommodation and coercion. The Assad regime in Syria is used to illustrate the regime insecurity loop. The chapter concludes by outlining the prospects of regime security in the developing world amid an increased transnationalization of security affairs.
17. Economic Security
Authors: Shiffman Gary M.
Published: August 2020

This chapter examines the concept of economic security as a framework for analysing and countering organized violence. It first provides a brief historical overview of the economic science of security and applies economic theory to Security Studies. Through various case studies, this approach allows the reader to understand how states leverage traditional economic tools to influence, alter, and deter another actor’s behaviour. The chapter considers three categories of organized violence: warfare, crime, and insurgency. It shows that the various decision makers involved in combating organized violence have different goals and face different constraints. It also describes five vectors of economic incentives: goals, resource constraints, institutional constraints, information, and time. Finally, it discusses four economic tools of security policy: sanctions, trade, finance, and aid.
18. Globalization, Development, and Security
Authors: Poku Nana K. , Therkelsen Jacqueline
Published: August 2020

This chapter explores the interrelationships between globalization, development, and security. It shows how globalization, as a neoliberal ideology for development promoted by key international financial institutions, deepens inequality between and within nations on a global scale. This exacerbates global insecurity through a growing sense of injustice and grievance that may lead to rebellion and radicalization. The chapter first considers the neoliberalism of globalization before presenting the case for conceptualizing globalization as a neoliberal ideology for development. It then discusses the legacy of structural adjustment programmes and the harmful effects of neoliberal ideology on societies, particularly across the developing world. Finally, it looks at two case studies to illustrate the link between uneven globalization and global insecurity: the Egypt uprising of 2011 and the Greek economic crisis of 2010.
1. Introduction: Strategy in the Contemporary World
Authors: Baylis John , Wirtz James J.
Published: August 2020

This book examines strategy in the contemporary world. Part I considers the enduring issues that animate the study of strategy and tackles topics ranging from the causes of war to questions about culture, morality, and war. Part II deals with issues that fuel strategic debates, with chapters on terrorism and irregular warfare, nuclear weapons, arms control, weapons of mass destruction, conventional military power, peacekeeping and humanitarian intervention, and cyberwar. Part III discusses critical and non-Western approaches to the study of strategy and security that have emerged in recent years and concludes by reflecting on future prospects for strategic studies. This introduction provides an overview of strategic studies, criticisms that are made of strategic studies, and how strategic studies relates to security studies.
2. The History of the Practice of Strategy from Antiquity to Napoleon
Authors: Heuser Beatrice
Published: August 2020

This chapter discusses the history of the practice of strategy from Antiquity to the First World War. After introducing the reader to the various definitions of strategy, the chapter considers sources of Antiquity about warfare, from ancient Greece and Rome to the time of Rome's Constantinopolitan (Byzantine) successors. Justinian I and Heraclius. It then examines episodes of European history since antiquity for which historians claim to have found evidence of the practice of strategy. In particular, it looks at the West European Middle Ages, which saw the rise of complex decision-making involving multiple tools — strategy. It also analyses the transformation of warfare and of strategy in early modern Europe, covering case studies that span the wars involving Philip II of Spain, Louis XIV of France, and Frederick II of Prussia, as well as the American War of Independence and the Napoleonic Wars.
3. The Evolution of Modern Warfare
Authors: Sheehan Michael
Published: August 2020

This chapter examines how the theory and practice of war has evolved over the past two centuries. It first provides an overview of modern warfare and the transformation in the way that wars are fought. In particular, it charts the decline of limited warfare and considers the ideas of Prussian career soldier Carl von Clausewitz, along with the emergence of the Napoleonic way of war and the legacy of Napoleon Bonaparte with regard to strategy. It then discusses the impact of the Industrial Revolution on the planning for and conduct of war, focusing on the ways that weapons technology transformed both strategy and tactics. It also explores the evolution of naval warfare, how nuclear weapons ended the era of total war, and the rise of revolutionary warfare. Finally, it reflects on how the transition to postmodernity can influence war as a politico-cultural institution.
4. Strategic Theory
Authors: Mahnken Thomas G.
Published: August 2020

This chapter examines strategic theory and how it provides a conceptual understanding of the nature of war. It begins with a discussion of the logic of strategy and how it applies not only in wartime, but also in peace. It then considers some of the most valuable concepts in strategic theory as articulated by Carl von Clausewitz in On War and compares them with Sun Tzu's ideas found in Art of War as well as in the military writings of Mao Tse-tung and jihadist writers. Clausewitz's views on war as a ‘paradoxical trinity’ — composed of violence, hatred, and enmity — and his understanding of the nature of a war, limited versus unlimited warfare, the rational calculus of war, and friction are explored. The chapter concludes with a commentary on the debate over whether classical strategic theory is obsolete.
6. Strategic Culture
Authors: Lantis Jeffrey S. , Howlett Darryl
Published: August 2020

This chapter discusses the ways that strategic culture can be relevant to scholarship and policymaking with regard to international security. It first provides an overview of three main approaches to the study of culture and strategy, paying attention to political culture as well as the relationship between strategic culture and nuclear deterrence. It then examines various sources of strategic culture identified in the literature, along with theoretical issues related to strategic culture. In particular, it explores the link between constructivism and strategic culture, the question of continuity in state behaviour and how strategic cultural dilemmas can cause changes in security policy, and the ‘keepers’ of strategic culture. The chapter also asks whether non-state, state, and multistate actors can possess distinctive strategic cultures before concluding with an analysis of the role of strategic culture in the acquisition of — and threats to use — weapons of mass destruction (WMDs).
8. Technology and Warfare
Authors: Cohen Eliot A.
Published: August 2020

This chapter discusses the role of technology in achieving victory in battle and the emerging technological trends that are likely to transform the way wars are conducted in the future. It first considers the debate over the importance of military technology in warfare before introducing the reader to some concepts about military technology, showing that military technologies often reflect different national styles. In turn, different national styles are determined by a variety of factors such as the search for technological edge. The chapter goes on to examine the debate regarding the revolution in military affairs and how asymmetric challenges such as irregular warfare and the threat of weapons of mass destruction can counterbalance superior conventional technology. It also explores the range of challenges presented by new technologies to military and political leaders before concluding with an analysis of the future of military technology.
15. Geography and Strategy
Authors: Moran Daniel
Published: August 2020

This chapter examines how geographical setting shapes the conduct of war. It first provides an overview of the ways that physical geography influences the tactical identities of armed forces as well as their strategic effects, focusing on practices that lie at the heart of ‘joint’ warfare — in which land, sea, and air forces cooperate to their collective advantage. The discussion highlights the strategic possibilities presented by warfare in different physical environments — that is, land warfare, naval warfare, and air warfare. The chapter also considers the strengths and weaknesses of forces that fight on land and sea and in the air, unconventional warfare fought on land, the maritime strategy employed by navies, theory vs. practice of air power, and coercive bombing. Finally, it analyses the strategic potential of space war, the expansion of war into cyberspace, and the use of ‘cyber’ weapons in information warfare.
16. Humanitarian Intervention and Peace Operations
Authors: Greitens Sheena Chestnut
Published: August 2020

This chapter analyses the dynamics of humanitarian intervention and peace operations. It begins with a discussion of the changing nature of peacekeeping since the cold war and how peacekeeping expanded in the post-cold war period, creating demand, opportunities, and incentives for intervention that resulted in an unprecedented increase in the number and scale of military interventions by United Nations forces. Today, humanitarian interventions are larger, more complex affairs. The chapter goes on to examine how post-cold war operations shaped peacekeeping debates, peacekeeping since 2000, the benefts and challenges of the regionalization of peacekeeping, and evolving norms in contemporary peacekeeping. It also considers the politics of humanitarian intervention, especially at the UN Security Council, and how public opinion of humanitarian intervention is shaped by media coverage and casualties. Finally, it describes the military character of peace operations as well as problems and prospects surrounding humanitarian intervention and peace operations.
19. Strategic Studies: The West and the Rest
Authors: Acharya Amitav , He Jiajie
Published: August 2020

This chapter examines the limitations and problems of strategic studies with respect to security challenges in the global South. It first considers the ethnocentrism that bedevils strategic studies and international relations before discussing mainstream strategic studies during the cold war. It then looks at whether strategic studies kept up with the changing pattern of conflict, where the main theatre is the non-Western world, with particular emphasis on the decline in armed conflicts after the end of the cold war, along with the problem of human security and how it has been impacted by technology. It also explores the issue of whether to take into account non-military threats in strategic studies and the debates over strategic culture and grand strategy in China and India. It concludes by proposing Global International Relations as a new approach to strategic studies that seeks to adapt to the strategic challenges and responses of non-Western countries.
20. Strategic Studies and its Critics
Authors: Peoples Columba
Published: August 2020

This chapter examines key themes in the criticism levelled at strategic studies. It begins with a discussion of the relationship between strategic studies and its critics in the ‘Golden Age’, a period that saw the rise to prominence of a new breed of strategic thinker, the ‘civilian strategist’. These civilian strategists favoured the incorporation of game theory and systems analysis into the study of nuclear strategy and deterrence. After reviewing prominent critical appraisals of deterrence theory in the 1960s, the chapter explains how these critiques were subsequently addressed by strategic theorists. It then considers the emergence of a ‘third wave’ of strategists that engaged in a reconstructive critique of strategy before concluding with an analysis of recent critical approaches to strategic studies that have focused on its role in constructing a particular Western-centric vision of world order, the relationship between strategic theory and policymaking, and the language of strategic studies.
5. Oil and Political Economy in the International Relations of the Middle East
Authors: Luciani Giacomo
Published: August 2020

This chapter looks at the role of oil in the political economy and the international relations of the Middle East. Oil is commonly considered a political commodity. Because of its pivotal importance as a primary source of energy, governments are concerned with its continued availability and seek to minimize import dependence. Historically, interest in oil — especially in the United Kingdom and the United States — strongly influenced attitudes towards the Middle East and the formation of the state system in the region, following the collapse of the Ottoman Empire. Oil also affects the power balance within the region. The polarization in the region between oil-rich and oil-poor states is thus an essential tool of analysis. The parallel distinction between rentier and non-rentier states helps to explain how oil affects the domestic political development of the oil-rich states and influences their regional relations.
10. Middle East Security: The Politics of Violence after the 2003 Iraq War
Authors: Calculli Marina
Published: August 2020

This chapter explores contemporary security in the Middle East by highlighting the nexus between the uses and justification of violence. Focusing on the post 9/11 reordering of the Middle East, it shows how state and non-state actors use the rhetoric of the ‘war on terror’ to depoliticize military interventions against political rivals. More specifically, it argues that such actors mobilize the politics of shame to contain and undermine their rivals. Such efforts are met with attempts to counter-shame and re-politicize the use of violence, producing a cycle of action and counter-action that seeks to legitimize and delegitimize competing visions of security and order in the Middle East. In this context, security and insecurity are two sides of the same coin that fluctuate according to the prevailing balance of power.
12. The Arab–Israeli Conflict
Authors: Smith Charles
Published: August 2020

This chapter discusses different aspects of the Arab–Israeli conflict over time — military, political, and economic. The first two decades of the Arab–Israeli conflict, often marked by armed hostilities, were notable for Arab refusal to recognize Israel's existence. Since the 1967 war, Arab states, specifically Syria and Saudi Arabia, have displayed willingness to recognize Israel, and two, Egypt and Jordan, have signed peace treaties; Yasser Arafat recognized Israel's right to exist in the 1993 Oslo agreement. In this regard, most Arab states have adopted a realist approach to the Arab–Israeli conflict, seeking coexistence based in part on acceptance of Israel's military supremacy. In contrast, Israel appears to insist on security through regional domination, coupled with retention of the West Bank as Greater Israel.
14. The International Politics of the Gulf
Authors: Legrenzi Matteo
Published: August 2020

This chapter focuses on the international politics of the Gulf region, which are defined by the interplay of the local states and outside powers. The domestic framework and its interactions with transnational influences and external actors are crucial to understanding the environment within which local states operate — whether revolutionary Iran, Saddam Hussein's Iraq, or the Gulf monarchies themselves. Given that regime security drives states in their foreign policies, the need to cope with both internal and external threats is compelling. Outside actors are important in as much as they supply or help to combat such threats. The withdrawal of US forces from Iraq and the relative immunity of the Gulf monarchies from the effects of the Arab Spring have afforded these states greater regional influence and autonomy, but events since 2015 also reveal deep divides among them over issues like IS, Iranian foreign policy, and the war in Yemen.
15. The Arab Spring: The ‘People’ in International Relations
Authors: Sadiki Larbi
Published: August 2020

This chapter looks at the Arab uprisings and their outcomes, approaching them from the perspective of the peoples of the region. The Arab uprisings are conceived of as popular uprisings against aged and mostly despotic governments, which have long silenced popular dissent. Ultimately, the Arab uprisings demonstrate the weakness of traditional international relations, with its focus on states and power, by showing how much the people matter. Even if the Arab uprisings have not yet delivered on popular expectations, and the Arab world continues to be subject to external interference and persistent authoritarian rule, they are part of a process of global protest and change, facilitated by new media and technology, which challenges the dominant international relations theories.
18. Europe in the Middle East
Authors: Hollis Rosemary
Published: August 2020

This concluding chapter explores the evolution and development of European approaches to the Middle East. An expansion of European imperial rule across the Middle East followed the collapse of the Ottoman Empire at the end of the First World War. By the end of the twentieth century, the United States was unrivalled power-broker across the region, but the Europeans had turned old imperialist relationships into commercial ones. Bound to MENA by economic interdependence and migration flows, the European Union (EU) formulated a series of initiatives designed to address new transnational security concerns through the deployment of ‘soft power’. By 2011 and the eruption of popular uprisings across the Arab world, the EU was itself in the throes of an economic crisis that forced a rethink in European policies toward the region and a reassertion of bilateralism.
The Gut Microbiome as a Reservoir for Antimicrobial Resistance
Authors: Anthony Winston E , Burnham Carey-Ann D , Dantas Gautam , Kwon Jennie H
Published: August 2020

This review will consider the gut as a reservoir for antimicrobial resistance, colonization resistance, and how disruption of the microbiome can lead to colonization by pathogenic organisms. There is a focus on the gut as a reservoir for β-lactam and plasmid-mediated quinolone resistance. Finally, the role of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome is discussed, along with the potential for future microbiome-directed methods to detect and prevent infection.
Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19
Authors: Guervilly Christophe , Burtey Stephane , Sabatier Florence , Cauchois Raphaël , Lano Guillaume , Abdili Evelyne , Daviet Florence , Arnaud Laurent , Brunet Philippe , Hraiech Sami , Jourde-Chiche Noémie , Koubi Marie , Lacroix Romaric , Pietri Léa , Berda Yaël , Robert Thomas , Degioanni Clara , Velier Mélanie , Papazian Laurent , Kaplanski Gilles , Dignat-George Françoise
Published: August 2020

Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.