bluuebunny/crossref_metadata_2025 huggingface dataset:
The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach
Authors: Ma Huibin , Xie Zhou , Huang Lina , Gao Yanyan , Zhan Linlin , Hu Su , Zhang Jiaxi , Ding Qingguo
Published: October 2022

Background. Transient ischemic attack (TIA) is a known risk factor for stroke. Abnormal alterations in the low-frequency range of the gray matter (GM) of the brain have been studied in patients with TIA. However, whether there are abnormal neural activities in the low-frequency range of the white matter (WM) in patients with TIA remains unknown. The current study applied two resting-state metrics to explore functional abnormalities in the low-frequency range of WM in patients with TIA. Furthermore, a reinforcement learning method was used to investigate whether altered WM function could be a diagnostic indicator of TIA. Methods. We enrolled 48 patients with TIA and 41 age- and sex-matched healthy controls (HCs). Resting-state functional magnetic resonance imaging (rs-fMRI) and clinical/physiological/biochemical data were collected from each participant. We compared the group differences between patients with TIA and HCs in the low-frequency range of WM using two resting-state metrics: amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF). The altered ALFF and fALFF values were defined as features of the reinforcement learning method involving a

Q

-learning algorithm. Results. Compared with HCs, patients with TIA showed decreased ALFF in the right cingulate gyrus/right superior longitudinal fasciculus/left superior corona radiata and decreased fALFF in the right cerebral peduncle/right cingulate gyrus/middle cerebellar peduncle. Based on these two rs-fMRI metrics, an optimal

Q

-learning model was obtained with an accuracy of 82.02%, sensitivity of 85.42%, specificity of 78.05%, precision of 82.00%, and area under the curve (AUC) of 0.87. Conclusion. The present study revealed abnormal WM functional alterations in the low-frequency range in patients with TIA. These results support the role of WM functional neural activity as a potential neuromarker in classifying patients with TIA and offer novel insights into the underlying mechanisms in patients with TIA from the perspective of WM function.
Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation
Authors: Luo Tianyu , Zhou Xiaoyi , Qin Minyan , Lin Yuqing , Lin Jiefen , Chen Guangpei , Liu Aijun , Ouyang Dongyun , Chen Dongfeng , Pan Hao
Published: October 2022

Corilagin, a gallotannin, shows excellent antioxidant and anti-inflammatory effects. The NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation diseases. However, it remains unclear how corilagin regulates the NLRP3 inflammasome to relieve gouty arthritis. In this study, bone marrow-derived macrophages (BMDMs) were pretreated with lipopolysaccharide (LPS) and then incubated with NLRP3 inflammasome agonists, such as adenine nucleoside triphosphate (ATP), nigericin, and monosodium urate (MSU) crystals. The MSU crystals were intra-articular injected to induce acute gouty arthritis. Here we showed that corilagin reduced lactate dehydrogenase (LDH) secretion and the proportion of propidium iodide- (PI-)stained cells. Corilagin suppressed the expression of N-terminal of the pyroptosis executive protein gasdermin D (GSDMD-NT). Corilagin restricted caspase-1 p20 and interleukin (IL)-1β release. Meanwhile, corilagin attenuated ASC oligomerization and speck formation. Our findings confirmed that corilagin diminished NLRP3 inflammasome activation and macrophage pyroptosis. We further discovered that corilagin limited the mitochondrial reactive oxygen species (ROS) production and prevented the interaction between TXNIP and NLRP3, but ROS activator imiquimod could antagonize the inhibitory function of corilagin on NLRP3 inflammasome and macrophage pyroptosis. Additionally, corilagin ameliorated MSU crystals induced joint swelling, inhibited IL-1β production, and abated macrophage and neutrophil migration into the joint capsule. Collectively, these results demonstrated that corilagin suppressed the ROS/TXNIP/NLRP3 pathway to repress inflammasome activation and pyroptosis and suggest its potential antioxidative role in alleviating NLRP3-dependent gouty arthritis.
Influence of SERPINA1 Gene Polymorphisms on Anemia and Chronic Obstructive Pulmonary Disease
Authors: Sangeetha Thangavelu , Nargis Begum Tajuddin , Balamuralikrishnan Balasubramanian , Arun Meyyazhagan , Rengasamy Kannan R. R. , Senthilkumar Natchiappan , Velayuthaprabhu Shanmugam , Saradhadevi Muthukrishnan , Sampathkumar Palanisamy , Vijaya Anand Arumugam
Published: October 2022

Background. Anemia is one of the predominant hematological conditions, whereas chronic obstructive pulmonary disease (COPD) is a predominant respiratory disease. These two diseases were found to be interlinked, but the physiological pathways are still unclear. Aim. The current study has been aimed at analysing the genetic interrelationship between anemia and COPD in accordance with different altitudes. Methodology. The genetic analysis was performed in the SERPINA1 gene of anemia, COPD, and healthy individuals for the analysis of single nucleotide polymorphism at rs28949274 and rs17580 locations. Result and Discussion. The single nucleotide polymorphism at the locations rs28949274 and rs17580 was present in both anemic and COPD patients. The COPD patients were more prone to mutations (63% had rs28949274, and 11% had rs17580 polymorphisms) than the anemic patients (40% had rs28949274, and 1% had rs17580 polymorphisms). On the basis of altitude, high-altitude individuals were found to be more susceptible to both the polymorphisms. Conclusion. Based on the current findings, we suggest that the SERPINA1 gene has a positive correlation with anemia as well as COPD, and the increase in altitude also influences the diseased conditions in a positive manner.
Numerical Analysis on the Bending Capacity of the Concrete-Filled Micro-Steel-Tube Piles
Authors: Chen Zaiqian , Pu Shutao , Wang Haicheng
Published: October 2022

The finite element analysis model is developed to investigate the bending capacity of the concrete-filled micro-steel-tube (CFMST) piles. First, the classical elastic-plastic model is employed to describe the constitutive relation of the steel material, while the plastic damage model is applied to portray the concrete material. Then, the three dimensional (3D) finite element numerical model for analyzing the flexural bearing capacity of the CFMST pile is established by virtue of the ABAQUS software. The reliability and accuracy of the present numerical model is carefully validated by comparing with the experimental data. The influence of the concrete strength grade, wall thickness of the steel tube, external diameter of the steel tube, and yield strength of the steel are analyzed in detail. It is shown that increasing the wall thickness/external diameter of the steel tube and the yield strength of the steel can greatly improve the flexural bearing capacity of the CFMST pile. Finally, a concise formula for the ultimate bending moment of the CFMST pile is proposed, which could be directly applied into the future engineering design.
A Certificateless-Based Authentication and Key Agreement Scheme for IIoT Cross-Domain
Authors: Wang Xiangyang , Gu Chunxiang , Wei Fushan , Lu Siqi , Li Zhaoxuan
Published: October 2022

The Industrial Internet of Things (IIoT) improves productivity and intelligent manufacturing process through revolutionary technology. Due to the complexity of the manufacturing process, cross-domain access is inevitable. Recently, Meng et al. proposed a secure and efficient blockchain-assisted entity authentication mechanism BASA for IIoT cross-domain. In the BASA scheme, the authors utilized identity-based signature (IBS) to realize mutual authentication and the Ephemeral Elliptic Curve Diffie-Hellman (ECDHE) exchange mechanism to negotiate the session key. Due to the inherent key escrow problem of identity-based cryptography (IBC), the key generation center (KGC) can obtain the session key negotiated between two entities distributed in different domains. When KGC is threatened, the security of the session key is worrying. Considering this security concern, based on the BASA scheme, in this article, we first show a secure and efficient certificateless public-key signature (CL-PKS) scheme with anonymity. Then, combined with the ECDHE key exchange mechanism, we give an efficient cross-domain authentication and key agreement scheme CL-BASA with the aid of consortium blockchain. After that, we make security verification by the formal analysis tool, Tamarin, which shows that our CL-BASA is secure. The evaluation demonstrates that our CL-BASA may have a slight disadvantage in storage overhead, but it has obvious advantages than competitor schemes in terms of communication overhead and computational overhead.
Investigating Reliability of Duimenshan High Rock Slope in Gejiu, Yunnan Province Based on the Monte Carlo Method
Authors: Fa-You A. , Pan Wan-cheng , Wu Wen-ping , Yan Shi-qun
Published: October 2022

A slope is a complex engineering geological body that contains many uncertainties. In the present study, the high rock slope of Duimenshan in Gejiu, China is taken as the research object, and the Monte Carlo method is used to perform the analyses. Firstly, based on a large number of rock mass discontinuities, the Fuzzy C-Means (FCM) clustering algorithm is used to determine the dominant discontinuities. Secondly, the affecting parameters of the rock mass such as cohesion, internal friction angle, horizontal seismic acceleration coefficient, and water-filled depth coefficient are taken as random variables, and the failure probability of the slope and the failure index corresponding to different slope heights and slopes are obtained as the output parameter. The obtained results show that the target reliability index of the slope in a certain range of the slope height is far from the safety value, indicating that the slope is unstable, and the combination of slope height and slope angle affects the reliability of the slope. More specifically, as the slope height and angle increase, the number of samples with a stability coefficient of less than 1 increases, thereby increasing the failure probability of the slope indicating that the slope is stable. It is found that unless the slope height is small, it is the main factor of stability. However, when the slope height exceeds 33 m, the effect of the slope inclination on the stability increases gradually.
Rural-Urban Labor Migration, Remittances, and Its Effect on Migrant-Sending Farm Households: Northwest Ethiopia
Authors: Bassie Haymanot , Sirany Teshome , Alemu Bizuayehu
Published: October 2022

The purpose of this research is to examine the impact of rural-urban labor migration and remittances on rural agricultural productivity. A rigorous random selection process was used to pick 480 households from cross-sectional data. For this investigation, both primary and secondary data were used. Stata version 16 was used to examine both qualitative and quantitative data using descriptive (mean, standard deviation, and percentages) and econometric (three-stage least square technique) analyses. According to the descriptive data, the majority of respondents used their remittances for consumption, to acquire agricultural inputs, and to pay back their debts and tax payments. According to econometric studies, rural-urban migration has little influence on agricultural productivity. Remittances, cultivated land, livestock ownership, and extension services, on the other hand, have a positive and significant effect on agricultural productivity. In a nutshell, the link between migration, remittances, and agricultural output in agrarian and rural families is remarkable. Agriculture is the major source of income and mostly handles the liquidity issue. Agriculture production in the study region is labor intensive, and it is influenced by the amount of effort utilized in production as well as the socioeconomic characteristics of the household. As a result, it must address the major conundrum of agricultural productivity, particularly rural-urban migration and remittances. Address a knowledge gap, begin activities, and develop and implement multiple initiatives by various responsible stakeholders that are essential for the research topic. Furthermore, agricultural extension service delivery should be improved by timely recruiting, frequent agent training, and appropriate logistics.
Quantitative Assessment Model of IT Operation and Maintenance Operation Risk Based on the Digital Twin Model
Authors: Qin Zhongyu , Liang Shaoyu , Liu Qin
Published: October 2022

In recent years, with the popularization of computer and information network technology, the core business of more and more industries has basically realized informatization office. Although the informatization office has brought a lot of convenience to people, the increasingly complex informatization infrastructure equipment has also buried many hidden dangers for people. More and more security incidents are caused by unfamiliarity with these infrastructures. How to use the information infrastructure correctly has become a problem considered by more and more enterprise information security departments, and the position of IT operation and maintenance is born to solve this hidden danger. The IT (Internet Technology) operation and maintenance personnel of each enterprise formulate a set of operational risk quantitative assessment models for the enterprise based on the internal information infrastructure equipment of the enterprise so that the enterprise staff can use these infrastructure equipment efficiently and safely. This paper focused on the quantitative assessment model of IT operation and maintenance operation risk constructed by the digital twin model. The quantitative assessment model of IT operation and maintenance operation risk constructed by the digital twin model was compared with the quantitative assessment model of IT operation and maintenance operation risk constructed by other traditional models. The comparison results showed that the output results of the evaluation model constructed by the digital twin model were closer to the actual results, and the accuracy rate was 35.9% higher than that of the previous operational risk assessment model.
Effect of Core Stability Training on Unstable Support Surfaces in Postoperative Rehabilitation of Thoracolumbar Vertebral Compression Fractures in the Elderly
Authors: Yin Yanfei , Cao Shixia , Wang Chenjie , Liu Yanju , Zhang Huakai
Published: October 2022

Objective. Thoracolumbar vertebral compression fractures (TVCF) are caused by anterior flexion or vertical downward violence to the spine (Sezer et al. 2021). This study is aimed at investigating the effect of core stability training (CST) on unstable support surfaces in the postoperative rehabilitation of TVCF in the elderly. Methods. Ninety-eight patients with TVCF who underwent surgical treatment in our hospital from July 2021 to April 2022 were selected as study subjects. Then, they were divided into a research group receiving unstable support surface CST and a control group with conventional rehabilitation training according to the random number table method. Before and after the training, the X-ray machine was positioned and the anterior margin and middle height ratio and the posterior convex Cobb angle of the injured vertebrae were observed, and the balance detector was used to detect patients’ eye opening and closing trajectory length, Romberg rate, and to perform gait test. Patients’ pain, lumbar spine function, and quality of life were subsequently assessed using the Visual Analogue Scale (VAS), Oswestry Dysfunction Index (ODI), Generic Quality of Life Inventory-74 (GQOL-74), and patient satisfaction with rehabilitation was investigated. Results. After rehabilitation training, there was no statistically marked difference in eye-opening trajectory length between both groups (

P
>
0.05

). The research group had higher scores than the control group in all dimensions of the anterior border of the injured vertebra, middle height ratio, and GQOL-74, while the posterior convex Cobb angle, closed-eye trajectory length, Romberg rate, VAS, and ODI were lower than the control group (

P
<
0.05

). The research group also revealed better gait improvement and higher rehabilitation satisfaction than the control group after training (

P
<
0.05

). Conclusion. Unstable support surface CST can effectively improve postoperative vertebral body rehabilitation, balance function, gait, pain conditions, and lumbar spine function in elderly TVCF patients, and enhance their quality of life and rehabilitation satisfaction. This trial is registered with ChiCTR2000014547.
ROS-Mediated Enamel Formation Disturbance Characterized by Alternative Cervical Loop Cell Proliferation and Downregulation of RhoA/ROCK in Ameloblasts
Authors: Xu Yuchan , Zhang Yunyan , Zheng Jingwen , Xu Mingxue , Yang Yuzhi , Guo Weihua
Published: October 2022

Reactive oxygen stress (ROS) is generally accepted as a signal transducer for coordinating the growth and differentiation of tissues and organs in the oral and maxillofacial region. Although ROS has been confirmed to affect the development of enamel, it is not yet known that the specific mechanism of ROS accumulation induced enamel defects. Given the lack of knowledge of the role of ROS in enamel, the aim of the study is to determine how oxidative stress affects cervical cells and ameloblast cells. Using SOD1 knockout mice, we identified a relationship between ROS fluctuations and abnormal enamel structure with HE staining, micro-CT, and scanning electron microscope. Increased ROS induced by H2O2, certified by the DCFH probe, has resulted in a dual effect on the proliferation and differentiation of cervical cells, indicating a higher tendency to proliferate at low ROS concentrations. Ameloblasts transfected with SOD1 siRNA showed a significant reduction of RhoA and ROCK. This study investigates for the first time that SOD1-mediated ROS accumulation disrupted normal enamel structure through alternative cervical loop cell proliferation and downregulation of RhoA and ROCK in ameloblasts, demonstrating the convoluted role of ROS in monitoring the progress of enamel defects.
Identification of Immune and Hypoxia Risk Classifier to Estimate Immune Microenvironment and Prognosis in Cervical Cancer
Authors: Shi Yujing , Gao Qing , Liu Zeyuan , Shen Gefenqiang , Sun Xinchen , Di Xiaoke
Published: October 2022

Purpose. Cervical cancer (CC) is one of the most common gynecologic neoplasms. Hypoxia is an essential trigger for activating immunosuppressive activity and initiating malignant tumors. However, the determination of the role of immunity and hypoxia on the clinical outcome of CC patients remains unclear. Methods. The CC independent cohort were collected from TCGA database. Consensus cluster analysis was employed to determine a molecular subtype based on immune and hypoxia gene sets. Cox relevant analyses were utilized to set up a risk classifier for prognosis assessment. The underlying pathways of classifier genes were detected by GSEA. Moreover, we conducted CIBERSORT algorithm to mirror the immune status of CC samples. Results. We observed two cluster related to immune and hypoxia status and found the significant difference in outcome of patients between the two clusters. A total of 251 candidate genes were extracted from the two clusters and enrolled into Cox relevant analyses. Then, seven hub genes (CCL20, CXCL2, ITGA5, PLOD2, PTGS2, TGFBI, and VEGFA) were selected to create an immune and hypoxia-based risk classifier (IHBRC). The IHBRC can precisely distinguish patient risk and estimate clinical outcomes. In addition, IHBRC was closely bound up with tumor associated pathways such as hypoxia, P53 signaling and TGF β signaling. IHBRC was also tightly associated with numerous types of immunocytes. Conclusion. This academic research revealed that IHBRC can be served as predictor for prognosis assessment and cancer treatment estimation in CC.
Performance of Ladle Furnace Slag in Mortar under Standard and Accelerated Curing
Authors: Sultana Iffat , Islam G. M. Sadiqul
Published: October 2022

This research preliminarily investigated the suitability of a locally available ladle furnace slag (LFS) as a partial replacement of cement in mortar. The raw material was first characterized to obtain its chemical and physical properties through particle size distribution, X‐ray fluorescence (XRF), X‐ray diffraction (XRD), and scanning electron microscopy (SEM). Later, the raw LFS was classified into two categories: (i) raw LFS and (ii) sieved (passing through #200 sieve) LFS and incorporated in mortars as a partial replacement of cement. Mortar prisms with 5, 10, 15, 20, 25, and 50% LFS (raw and sieved) were prepared and cured under normal temperature (NTC) for 7, 28, and 56 days. Additional mortar prisms (with raw and sieved LFS) were prepared by curing them under high‐temperature accelerated curing (HTAC) for 7 days. The characterization tests suggest that CaO, SiO2, MgO, and Al2O3 are the main compounds of raw LFS used in this study. The mineralogical phases present in the raw slag are calcio‐olivine, akermanite, α‐quartz, merwinite, magnetite (Fe3O4), and calcium‐aluminium oxide. Both raw and sieved LFS‐blended mortars yield good consistency up to 25% cement replacement in mortars. The compressive strength of NTC mortar suggests that 5% and 10% replacement of cement with raw and sieved LFS yields higher strength than the control mortar. Seven days strengths of raw and sieved LFS blended mortars obtained for HTAC are closely comparable to that of 28 days under NTC. This study recommends that LFS could be a sustainable supplementary material to use as a partial replacement of cement in mortar, preferably up to a level of 15% for standard works.
Application of Sports Clustering Deconstruction Based on Neural Network
Authors: Ma Xiaobing
Published: October 2022

Sports cluster analysis can mainly provide more teaching ideas for physical education. Teachers can make scientific and reasonable arrangements for the teaching plan according to the analyzed data results, so as to achieve better teaching purposes. However, due to various factors such as exercise time and course time conflict, this method cannot be widely used. The neural network had a good memory function, and it can be used to integrate physical education resources in sports. Then, a knowledge framework was formed by simulating a large number of human brain neuron structures, which can solve the problems existing in the motion cluster analysis to a certain extent. In this paper, the sports based on neural network is used to improve the problems existing in the practical teaching application of sports clustering analysis. A teaching system model based on motion recognition was established to improve motion cluster analysis and promote the implementation of data-based education. According to the experimental data obtained from the experimental test, people can know that the detection rate of the sports cluster analysis model is about 89.5%, and the average missed detection probability is about 5.5%.
Electrospun Fibers: Versatile Approaches for Controlled Release Applications
Authors: Karimi Afshar Sepideh , Abdorashidi Mohammadmohsen , Dorkoosh Farid Abedin , Akbari Javar Hamid
Published: October 2022

Electrospinning has been one of the most attractive methods of fiber fabrication in the last century. A lot of studies have been conducted, especially in tissue engineering and drug delivery using electrospun fibers. Loading many different drugs and bioactive agents on or within these fibers potentiates the efficacy of such systems; however, there are still no commercial products with this technology available in the market. Various methods have been developed to improve the mechanical and physicochemical behavior of structures toward more controllable delivery systems in terms of time, place, or quantity of release. In this study, most frequent methods used for the fabrication of controlled release electrospun fibers have been reviewed. Although there are a lot of achievements in the fabrication of controlled release fibers, there are still many challenges to be solved to reach a qualified, reproducible system applicable in the pharmaceutical industry.
A Theranostic Approach for CAR-T Cell Therapy
Authors: Weber Wolfgang A. , Varasteh Zohreh , Fritschle Katja , Morath Volker
Published: October 2022

Fibroblast activation protein (FAP) is frequently expressed in the tumor stroma, whereas expression by normal organs is highly restricted. Despite these promising features, FAP-targeted therapies have shown limited success so far. FAP imaging offers new opportunities to select patients for FAP-targeted therapies and monitor tumor response.

See related article by Lee et al., p. 5330
Proceedings of the 2022 Cannabis Clinical Outcomes Research Conference
Authors: Smolinski Nicole E. , Sajdeya Ruba , Cook Robert , Wang Yan , Winterstein Almut G. , Goodin Amie
Published: October 2022

The Consortium for Medical Marijuana Clinical Outcomes Research, a multi-university collaboration established by the state of Florida in the USA, hosted its second annual Cannabis Clinical Outcomes Research Conference (CCORC) in May 2022. CCORC was held as a hybrid conference, with a scientific program consisting of in-person and virtual sessions. CCORC fostered and disseminated current research on clinical outcomes of medical marijuana while stimulating collaboration and engagement between the scientific community, policymakers, industry representatives, clinicians, and other interested stakeholders. Three themes emerged from conference sessions and speakers: (1) disentangling research findings comparing use and outcomes of medical and nonmedical cannabis, (2) addressing barriers and promoting facilitators for clinical cannabis research, and (3) resolving uncertainties around cannabis dosing. The third annual CCORC is planned for the summer of 2023 in Florida, USA.
Parents behavior for delivering adolescent reproductive health education
Authors: Kusumaningrum Tanjung Anitasari Indah , Suci Diah Laras , Wulandari Dini
Published: October 2022

Adolescence is a period of searching for identity that requires information on reproductive health and sexuality so as not to fall into premarital sexual behavior. Parents play an important role in providing reproductive health information to adolescents. The purpose of this study was to analyze the relationship between partner support, perceived barriers, and self-confidence with parents behavior for giving  adolescent reproductive health education. The research employed a cross sectional approach which was conducted online in June-August 2020 to 300 parents of teenagers aged 15-19 years. The sampling technique is double sampling using self-administered questionnaire that has been tested for validity. Bivariate analysis was performed using Chi square and multivariate analysis was performed using logistic regression test. The results showed that parents' self-confidence was the most influential factor in reproductive health education for adolescents (OR=3.052, CI=1.534-6.071). Parents who have low self-confidence tend not to provide comprehensive reproductive health information to adolescents. Lack of skills to explain the topic of sexuality, lack of  knowledge of the material that will be given, and the shame when conveying sexuality material is something that affects parents' self-confidence. Training is needed for parents on how to provide information on reproductive health to adolescents.
Dengue hemorrhagic fever incidence in Indonesia using trend analysis test and spatial visualization
Authors: Gani Helmy , Maharja Rizky , Salcha Muhammad Akbar , Gani Hamdan , Wardhani Nurilmiyanti , Nurani Nurani , Gani Nur Fadhilah , Maharja Riadnin
Published: October 2022

Dengue hemorrhagic fever (DHF) caused a public health risk in many developing countries, so understanding their incidence trend is needed to prepare for early warning prevention. The multi-year DHF trend analyses with spatial analysis are necessary but have not been accomplished in Indonesia. Therefore, this study aimed to present the current and future trends of DHF disease incidence in Indonesia during 2007-2022. This study examined the trends using yearly data of DHF for all provinces. The total number of DHF cases (DHF cases), the total death associated with DHF (TDC), case fatality rate (CFR), and infection rate (IR) are utilized. Univariate forecasting model, trend analysis test, and spatial visualization were developed. The results per province showed a declining trend of DHF cases and TDC in Java Island. There was an increasing trend outside Java Island. For the CFR and IR, most provinces had decreasing trend except for Gorontalo, North Kalimantan, and Maluku. Overall, trend analysis showed a continually decreasing trend of DHF, TDC, CFR, and IR that shows the positive results of the eradication program over 16 years. The findings highlighted the high-risk areas and need control strategies for DHF incidences.
Personal standards and evaluative concerns perfectionism on mattering among Gen-Z
Authors: Lee Zoe , Prihadi Kususanto Ditto , Rachma Eva Nur
Published: October 2022

This study aimed to investigate whether a personality disposition called perfectionism plays a significant role in predicting the sense of mattering. The role of two major elements of perfectionism, namely evaluative concern perfectionism (ECP) and personal standard perfectionism (PSP) was investigated. ECP was considered as the predictor due to the nature of its contingency upon one’s perception of others’ standard of acceptance, while PSP was included as a moderator because the level of personal standard might determine how ECP predicts the sense of mattering. Participants were purposively recruited to make sure that they were members of Generation-Z (Gen-Z). As many as 130 undergraduate students aged 18 to 24 years old were asked to respond to the subscales of the Frost multidimensional perfectionism scale and the interpersonal mattering scale through an online survey. The data was analyzed with a help of the software of PROCESS Macro for bootstrapping method with 95% confidence interval and 5,000 samplings. The results revealed that when PSP is at its highest levels, the link between ECP and mattering is no longer significant. Thus, a perfectionist individual tends to feel they matter more when their concern about others’ opinions is higher, but not when they have higher levels of personal standards.
Secure relationship does not mean satisfying relationship during the pandemic: The role of mattering and life satisfaction
Authors: Yeoh Hong Chun , Poay Susanna Lin Hong , Prihadi Kususanto Ditto , Purwaningtyas Endah Kurniawati
Published: October 2022

Relationship satisfaction (RS) is one of the major components of mental health that is often ignored due to cultural reasons. Moreover, numerous studies had indicated that when individuals have insecure attachment styles (insecurity in loving someone else), they would never develop any RS with anyone, including friends, spouses, parents, children, and relatives. The coronavirus disease 2019 (COVID-19) pandemic had triggered different social patterns among individuals all over the world, and studies during the pandemic indicated the significance of some factors such as the sense of mattering and perceived life satisfaction (LS) to the mental health of the general adults. Our references led us to hypothesize that interpersonal mattering (IM) significantly predicted RS, mediated by LS, under the condition of low secure attachment style (SAS). Randomly selected 405 adults from Kuala Lumpur and Selangor, Malaysia, were financially compensated to complete the scales of IM, satisfaction with life, SAS section of measure of attachment style (MOAS), and RS index. The results indicated that the mediation of LS on the link between mattering and RS was only significant when the level of SAS is at the low and moderate levels. Further implications, limitations, and suggestions are discussed.
Factors influencing provision of basic emergency obstetric care services in Luzon, Philippines
Authors: Cagayan Maria Stephanie Fay Samadan , Armada Gladys Larissa V. , Castro Mary Christine R. , Nisperos Gene Alzona
Published: October 2022

The basic emergency obstetric and newborn care (BEmONC) strategy was designed to provide evidence-based interventions at the primary level to control maternal and newborn mortality. With less than a decade until the conclusion of the sustainable development goals, much work remains to be done in the Philippines to achieve the set target on maternal mortality. Recognition of the determinants affecting its implementation may elucidate what still needs to be addressed. This study aimed to identify the facilitators and barriers to accessibility of quality BEmONC services. Eight focus group discussions consisting of BEmONC providers were conducted from February to April 2021. These were recorded, transcribed, then translated into English. Data then underwent thematic analysis using NVivo to identify emerging themes and subthemes. There were 102 health care providers who participated in the study. There were four main themes emerged: institutional capacity, service capacity, personnel capacity, and external factors. Each had its corresponding subthemes, such as infrastructure, human resources, referrals, and local government support, respectively. Factors and/or barriers to each subtheme were identified during the discussions. The study provided important insight on the factors influencing BEmONC utilization. Focal points recognized may be used by policy makers and key stakeholders to allow optimal provision of BEmONC services.
They can handle it, they are leaders: a look into organizational leaders’ mental health
Authors: Octavia Josephine , Prihadi Kususanto Ditto , Yeoh Hong Chun , Purwaningtyas Endah Kurniawati
Published: October 2022

Few studies have examined the mental health of people in a leadership position. Most of the time, mental health-related policies were created for the non-leaders to cope with the perceived pressure from their leaders. Nevertheless, the mental health of organizational leaders itself might be at stake due to the leadership ‘acts’ they have to perform. This current study aimed to investigate the moderating effect of social support and self-compassion on the relationship between organizational leaders’ emotional labor and their psychological well-being. There were mid-level working executives in leadership positions provided data on their emotional labor, social support, self-compassion, and psychological well-being. It was predicted that social support and self-compassion will both moderate the relationship between organizational leaders’ emotional labor and their psychological well-being. The results indicated that surface acting is correlated with psychological wellbeing while deep acting is not. Social support and self-compassion do not moderate the relationship between emotional labor and psychological wellbeing. However, age is significantly correlated with psychological wellbeing, social support, and self-compassion, indicating its importance in leaders.
Potential hepatic-protective effect of Physalis peruviana against lead-induced toxicity in albino rats
Authors: Gad Fatma Ismail , Salem Eglal Ghoneim , Abdullatef Ossama A , Aborhyem Samar M
Published: October 2022

Lead toxicity poses a serious threat facing humanity. Research aims to investigate the potential hepato-protective effect of Physalis peruviana (P.P) fruit against lead toxicity (10 ppm (1/45 LD50)) in male albino rats. Toxicological induction with lead acetate lasted for 28 days followed by treatment with 200, 300, and 500 mg/kg of lyophilized P.P. fruit extract for another 28 days. Superoxide dismutase, malonaldehyde, catalase, and glutathione peroxidase were measured using a spectrophotometer. Lead concentration in liver tissues was assessed using Atomic Absorption Spectroscopy after four and eight weeks, in addition to Aspartate aminotransferase, alanine aminotransferase, and complete blood count were measured. Lead acetate induced a substantial elevation in malonaldehyde levels, and a significant decrease in Superoxide dismutase, catalase, and glutathione peroxidase activities. Treatment with 200, 300, and 500 mg/kg P.P showed an improvement in the activity of the antioxidant enzymes in a dose-dependent manner. Co-administration of P.P. ameliorates the damage caused by lead acetate. Physalis peruviana solution showed a reduction in the mean lead concentration in a dose-dependent response of 0.26±0.02, 0.21±0.02, and 0.14±0.03 ppm for groups III, IV, and V, respectively. In conclusion, P.P. fruit extract can improve antioxidant activity and exert a beneficial effect in the treatment of Pb-induced hepatotoxicity.
Comparing well-being among rural and urban Indonesian older people: a quantitative analysis of the related factors
Authors: Widagdo The Maria Meiwati , Pudjohartono Maria Fransiska , Meilina Meilina , Mete Angela Rosalia , Primagupita Adhiyasa , Sudarsana Kadek Dewi Armitha Putri
Published: October 2022

Residential area has been identified as a factor that influences the well-being of older people. This study aimed to compare the well-being of older people living in urban and rural areas in Yogyakarta province, Indonesia, and analyze the predictors of well-being. A total of 141 (79 rural and 62 urban) older people participated in this study. Well-being was assessed using the world health organization-five (WHO-5) well-being index. The factors measured included sociodemographic data (age, sex, educational level, living arrangements, and current employment status), physical function, cognitive function, depression, independence, and attitude towards aging. Data of the two groups were compared using t-tests and Chi-square analysis. Correlations with well-being were analyzed using univariate correlation and multivariate hierarchical regression. The urban group had slightly older age, higher education, lower mobility and balance, higher attitude scores, and higher well-being. Depression was a significant variable in well-being for both communities. Physical capacity was an important factor in urban populations, while well-being in rural areas was better predicted by independence and cognitive function. The results suggest that there are similar and different correlates of the well-being of rural and urban older people, recommending different programs to enhance the well-being of older people living in different areas.
The trend of sharenting among Malaysian parents: a preliminary study of intention and motivation
Authors: Tan Crendy Yen Teng , Dhanapal Saroja
Published: October 2022

Social media platforms and applications are increasing exponentially and has become a part of life. It is widely used to connect with large numbers of people without investing much time and effort. This led to the emergence of a new term, ‘sharenting’ which refers to parents sharing children’s information on social media. The trend of sharenting is predominant and has raised concerns in the western countries, but in Malaysia there is still a lack of adequate knowledge on this trend. Past research on sharenting focuses on the usage frequency, content and consequences of sharenting in Western countries. However, there is a dearth of literature on the intention and motivation of Malaysian parents to this trend. Thus, the current study employed a qualitative approach to explore Malaysian parents’ intention and motivation of sharing children’s information on social media through the framework of Bandura’s social learning theory. The sample comprising of Malaysian parents aged between 20 to 40 who share their children’s information on social media were interviewed and the findings were analyzed using a thematic approach. This research is significant as it provides knowledge on the trend of sharenting of Malaysian parents. The paper ends with recommendation for further future research.
Mortality and morbidity among pregnant women with COVID-19 infection: a meta-analysis
Authors: Musyarrofah Aida , Illahika Anung Putri , Putra Probo Yudha Pratama , Eka Putri Dinda Amalia , Zatalini S. Khansa , Prasetyo Yohanes Eddy
Published: October 2022

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and declared as a global pandemic in March 2020. There is a special immune tolerance in pregnant woman, predisposes to a viral infection, then increased risk severe complication. Meta analysis was performed using preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidlines with comprehensive literature study was performed in July 2021 through Science Direct, Cochrane, and PubMed, with keywords “COVID-19”, “SARS-CoV-2”, “pregnancy”, “pregnant”, and “complication”, and each parameter we assessed using review manager 5.3. Nine studies with 30,257 infected patients and 1,678,974 non infected patients were included. The data show that preterm birth (odds ratio (OR)=1.43, 95% confidence interval (CI): 1.17-1.74; p=0.0004, inconsistency (I2) =90%) less in non infected groups, no camparable finding in vaginal delivery (OR=0.93, 95% CI: 0.82-1.06; p<0.030, I2=75%) and caesarian delivery (OR=1.07, 95% CI: 0.90-1.28; p<0.045, I2=96%). Intensive care unit (ICU) admission reported high percentage in infected patients (OR=4.87, 95% CI: 3.08-7.71; p<0.0001, I2=93%), we found that obstetric complication in subgroup (OR=1.31, 95% CI: 0.13-1.52; p<0.0003, I2=54%) and mortality (OR=17.41, 95% CI: 11.04-27.46; p<0.0001, I2=0%) less in non infected patients. Pregnancy with infected COVID-19 has high percentage of mortality and morbidity events. Infected and non infected patient has equal chance for vaginal or caesarian delivery.
Spatial-temporal distribution of dengue in Banjarmasin, Indonesia from 2016 to 2020
Authors: Rosvita Nur Afrida , Kania Nia , Suhartono Eko , ‪Nugroho Adi , Wydiamala Erida
Published: October 2022

Dengue hemorrhagic fever (DHF) is an acute febrile disease caused by four serotypes of dengue virus (DENV) and transmitted by the Aedes aegypti mosquito. This article aims to analyze monthly trends in cases and climates as well as spatial analysis and autocorrelation in 52 urban villages of Banjarmasin city. Laboratory-confirmed dengue cases from 2016 to 2020 were analyzed for trends in malaria cases. Decomposition analysis was performed to assess seasonality. The annual spatial grouping of incidents, identified by Moran's I. The result shows the annual dengue incidence decreased significantly to 72% in 2017 and lasted until 2020. Dengue infection is more common in men with an age range of 15-64 years. The monthly dengue season is highest from January to May along with increased rainfall. The high incidence is spatially clustered which is identified in the east and borders neighboring districts, especially six urban villages. A trend and spatially explicit decision support system are needed to support surveillance and control programs in identified high-risk areas to succeed in dengue eradication goals.
Community-based quit smoking intervention in Sarawak, Malaysia
Authors: Daud Muhammad Siddiq , Rahman Md Mizanur , Lukas Sabrina , Kana Kamarudin , Aren Merikan , Ajeng Rudy Ngau , Gahamat Mohd Faiz
Published: October 2022

Rising worldwide adolescent smoking necessitates national and global research to establish intervention methods. This research evaluated the efficacies of ask, advise, assess, assist, arrange (5A’s) and ask, advise, act (3A’s) interventions. Self-reported quit-smoking attempts were the outcome measure. Six villages were randomly selected and equally divided into three groups: 5A’s, 3A’s, and control (no intervention). There were 519 current participant-smokers aged 13-17 followed-up by phone (first and third months) and face-to-face interviews (sixth and ninth months). Most 3A’s participants (n=12, 7.1%) quitted smoking in the first month, followed by the 5A’s (n=9, 5.3%) and the control (n=3, 1.9%). In the third month, 5A’s participants topped the rank (n=16, 10.7%), followed by the 3A’s (n=14, 9.2%), and control (n=5, 3.4%). As per sixth-month follow-up, the 5A’s group maintained its position on top of the list (n =27, 21.4%), followed by the 3A’s (n=22, 17.1%) and the control (n=5, 4.0%). The majority of 5A’s participants quitted smoking after nine months (n=36, 33.0%), followed by the 3A’s (n=27, 25.5%), while control maintained its position (n=5, 5.0%). Division health officers and school health-teams nationwide should implement them.
Colchicine as adjuvant therapy in COVID-19 patients: a meta-analysis
Authors: Rachma Betty , Putra Probo Yudha Pratama , Putri Dinda Amalia Eka , Zulaifah Zakiya , Prameswari Arlinda Silva
Published: October 2022

SARS-CoV-2 infection results in hyperinflammatory responses by activating proinflammatory cytokines and chemokines. Colchicine is an anti-inflammatory drug that reduces superoxide production, tumor necrosis factor alpha (TNF-α) activation, and neutrophil chemotaxis. This study aimed to understand the effect of adjuvant colchicine on mortality in COVID-19 patients. Systematic literature searching was conducted on PubMed, ScienceDirect, Cochrane Library, and medRxiv with keywords colchicine, coronavirus disease, COVID-19, mortality, and SARS-CoV-2. Five randomized controlled studies with 15,779 patients were included. There was no significant difference between the colchicine group and the standard group (OR 1.00 [95% CI 0.91-1.09], p=0.94); invasive mechanical ventilation necessity also did not show a significant difference (OR 0.99 [95% CI 0.83-1.17 p=0.88). There was no significant difference in the incidence of cardiovascular disease (OR 1.11 [95% CI 0.50-2.46], p=0.79), also the incidence of pneumonia was lower in colchicine group (OR 0.68 [95% CI 0.49-0.93], p=0.02), while the incidence of gastrointestinal complaints was higher in colchicine group (OR 2.09 [95% CI 1.84-2.37], p<0.00001). Colchicine as COVID-19 adjuvant therapy did not significantly reduce mortality, the need for invasive mechanical ventilation, and the incidence of cardiovascular disease. Furthermore, the colchicine group had lower pneumonia incidence and higher gastrointestinal complaint incidence.
Applying the health belief model in identifying individual understanding towards prevention of type 2 diabetes
Authors: Afrasiabi Fateme , Behesht aeen Fateme , Kargar jahromi Marzieh
Published: October 2022

Diabetes is a prevalent metabolic disorder, which leads to numerous complications. This disease can be prevented by training people and increasing their awareness via the health belief model. This descriptive study aimed to determine the diabetes prevention behaviors based on the health belief model among high-risk individuals. There were 220 randomly selected individuals at risk of type 2 diabetes completed a 65-item questionnaire based on the constructs of the health belief model. Data were analyzed by statistical package for the social sciences (SPSS). The mean score of knowledge among respondents was 5.54+2.60, which indicated that 50.36% of the participants had gained the maximum score of knowledge. The results indicated that the constructs of the health belief model determined 19% of the variance in type 2 diabetes prevention behaviors. Perceived barriers, perceived self-efficacy, and knowledge were the significant positive predictors of diabetes prevention behaviors. In addition, a significant relationship was observed between age, economic status, and education level and some constructs of the health belief model. The results indicated that the high-risk patients obtained moderate mean scores in type 2 diabetes prevention behaviors. These results could improve educational programs with regard to beliefs, attitudes, and behaviors to promote type 2 diabetes prevention and self-care behaviors among at-risk populations.
 