bluuebunny/crossref_metadata_2025 huggingface dataset:
Shifting the Paradigm: The Transformative Role of Neoadjuvant Therapy in Early Breast Cancer
Authors: Hirmas Nader , Holtschmidt Johannes , Loibl Sibylle
Published: September 2024

The use of neoadjuvant systemic therapy (NST) has become increasingly important in the treatment of breast cancer because of its various advantages. These include the ability to downstage tumors without compromising locoregional control and the potential to obtain valuable information about clinical and biological response to therapy with implications for individual prognoses. Surgical response assessment paves the way for response-adapted therapy, and pathological complete response (pCR; defined as ypT0/is ypN0) serves as an additional endpoint for drug development trials. Recommended NST regimens commonly consist of anthracyclines and taxane, with dose-dense anthracyclines and weekly paclitaxel often preferred, whenever feasible. For patients with human epidermal growth factor receptor-2 (HER2)-positive tumors, dual anti-HER2 therapy (trastuzumab and pertuzumab) is indicated together with NST in case of elevated risk of recurrence. For patients with triple-negative breast cancer (TNBC), adding carboplatin to NST correlates with improved pCR and survival rates, as does the addition of immune checkpoint inhibitors. For hormone receptor (HR)-positive/HER2-negative cancers, emerging data on NST including immune checkpoint inhibitors may elevate the significance of NST in high-risk luminal breast cancer. Here, we present a synthesis of the results from neoadjuvant clinical trials that aim at optimizing treatment options for patients with high-risk breast cancer.
Indigeneity as a Post-Apocalyptic Genealogical Metaphor
Authors: Tecun Arcia
Published: September 2024

This paper is a theoretical exploration that works through a global Indigenous consciousness. As a critically reflexive story work and auto-ethnographic contemplation it begins by confronting a presumed genealogy in a post-apocalyptic world of coloniality through a global Indigenous lens. Extending beyond racially legalised genealogical ancestry, the metaphysics of indigeneity in the context of Western modernity can be re-positioned as a metaphor of past future human-being-ness or person/people-hood. Global Indigeneity and Indigenous metaphysics are framed as a portal and entry beyond coloniality through fugitive sociality and subversive relationality. Confronting the tensions of colonially purist and racially essentialist categories of indigenous identity, lineages of the post-post-apocalyptic world are forming in the enduring social connections embodied in an Indigenous genealogical consciousness of the present.
Time for a Re-Think? The Rationale for Multi-Component Intervention to Prevent Malnutrition in At-Risk Community-Dwelling Older Adults
Authors: Naylor Johnny , Johnstone Alexandra M. , Myint Phyo K.
Published: September 2024

Dietary strategies for early intervention in older adults are highly desirable, as they encourage individuals to retain a good functional status despite morbidity [...]
Purslane (Portulaca oleracea L.) Growth, Nutritional, and Antioxidant Status under Different Nitrogen Levels in Hydroponics
Authors: Chrysargyris Antonios , Xylia Panayiota , Zengin Gokhan , Tzortzakis Nikolaos
Published: September 2024

Purslane (Portulaca oleracea L.) is a common weed that attracts research and agricultural attention because of its significant nutritional value, and it is used commercially. The present work rated the effect of different nitrogen (N) concentrations, i.e., N50: 50 mg L−1; N100: 100 mg L−1; N200: 200 mg L−1; and N300: 300 mg L−1, on the growth, physiology, antioxidant capacity, and nutrient accumulation in the different plant parts of hydroponically grown purslane. Seedlings were transplanted to a Nutrient Film Technique (NFT) system and exposed to different N levels. The plants grown in high N levels of 300 mg L−1 had decreased biomass production, leaf number, leaf stomatal conductance, and total flavonoid content because of the increased oxidative stress, as shown by the elevated lipid peroxidation levels. Several enzymatic (superoxide dismutase) and non-enzymatic (ascorbic acid, total phenolics) plant antioxidant activities were activated to counteract the oxidative factors. Plants grown in intermediate N levels in the NS (i.e., 100 mg L−1) had decreased oxidative stress as several enzymatic antioxidant activities, i.e., peroxidases and catalases, were increased. Additionally, the water use efficiency and nitrogen uptake, as well as leaf stomatal conductance and leaf chlorophyll fluorescence, were increased in plants grown at a N level of 200 mg L−1. The mineral accumulation in the leaves, stems, and roots fluctuated, with increased calcium, magnesium, and sodium content being observed in the plants grown at high N levels in the nutrient solution. The stems accumulated less N compared with the leaves, but the N content and accumulation rates in purslane leaves were not affected by the N levels in the nutrient solution. Therefore, to increase the yield, nutritional value, and water use efficiency of purslane that is grown hydroponically, a concentration of 200 mg L−1 N in the nutrient solution is recommended.
Expression of Cystathionine-β-Synthase (CBS) Genes in Grape under Various Abiotic Stresses and Subcellular Localization of VvCBS27
Authors: Shi Xingyun , Xu Shanshan , Li Yandong , Yin Yiming
Published: September 2024

The cystathionine-β-synthase (CBS) domain is present in the proteins of all living organisms and functions as an energy sensor, regulating protein activity through the binding capacity of its adenosine ligands. The role of the CBS gene in plant growth and development, as well as tolerance to abiotic stresses, remains largely unknown, especially in grapevine. In our study, 32 members of the CBS gene family were obtained that were distributed on 15 chromosomes. The results of the structural and evolutionary tree analyses indicated that the VvCBS gene family exhibits diverse intron-exon patterns and highly conserved motifs. Furthermore, the phylogenetic classification of the VvCBS genes revealed the presence of three subfamilies. Subcellular localization analyses showed that the VvCBS genes are mainly located in the plasma membrane region. The secondary structure of the VvCBS protein mainly consists of α-helices, extended strands, β-turns, and random coils. The VvCBS gene family exhibited four co-linear gene pairs, while the numbers for Arabidopsis thaliana and rice were 21 and 7, respectively. The promoter cis-acting element analysis revealed the presence of light-responsive, hormone-responsive, stress-responsive, and growth- and development-related elements in the VvCBS family. The expression characterization demonstrated that 12 VvCBS genes exhibited high expression levels in all grape tissues. Additionally, the RT-qPCR expression analyses showed that the 32 VvCBS exhibited different responses to a variety of abiotic stresses (cold, drought, salt), suggesting that they were functionally differentiated. VvCBS27 was cloned from ‘Pinot Noir’ of grapevine with a coding sequence of 624 bp. Subcellular localization showed that VvCBS27 protein was mainly located in the cytoplasm, cell membrane, and nucleus. This study lays a foundation for elucidating the function of grape CBS protein.
Polyethylene Micro/Nanoplastics Exposure Induces Epithelial–Mesenchymal Transition in Human Bronchial and Alveolar Epithelial Cells
Authors: Traversa Alice , Mari Emanuela , Pontecorvi Paola , Gerini Giulia , Romano Enrico , Megiorni Francesca , Amedei Amedeo , Marchese Cinzia , Ranieri Danilo , Ceccarelli Simona
Published: September 2024

Micro/nanoplastics (MNPs), which are widely spread in the environment, have gained attention because of their ability to enter the human body mainly through ingestion, inhalation, and skin contact, thus representing a serious health threat. Several studies have reported the presence of MNPs in lung tissue and the potential role of MNP inhalation in triggering lung fibrosis and tumorigenesis. However, there is a paucity of knowledge regarding the cellular response to MNPs composed of polyethylene (PE), one of the most common plastic pollutants in the biosphere. In this study, we investigated the effects of low/high concentrations of PE MNPs on respiratory epithelial cell viability and migration/invasion abilities, using MTT, scratch, and transwell assays. Morphological and molecular changes were assessed via immunofluorescence, Western blot, and qRT-PCR. We demonstrated that acute exposure to PE MNPs does not induce cellular toxicity. Instead, cells displayed visible morphological changes also involving actin cytoskeleton reorganization. Our data underlined the role of epithelial–mesenchymal transition (EMT) in triggering this process. Moreover, a remarkable increase in migration potential was noticed, in absence of a significant alteration of the cell’s invasive capacity. The present study highlights the potential impact of PE MNPs inhalation on the human respiratory epithelium, suggesting a possible role in carcinogenesis.
Cholesterol-Dependent Serotonin Insertion Controlled by Gangliosides in Model Lipid Membranes
Authors: Fantini Jacques , Azzaz Fodil , Bennaï Ryad , Yahi Nouara , Chahinian Henri
Published: September 2024

Serotonin is distinct among synaptic neurotransmitters because it is amphipathic and released from synaptic vesicles at concentrations superior to its water solubility limit (270 mM in synaptic vesicles for a solubility limit of 110 mM). Hence, serotonin is mostly aggregated in the synaptic cleft, due to extensive aromatic stacking. This important characteristic has received scant attention, as most representations of the serotonergic synapse take as warranted that serotonin molecules are present as monomers after synaptic vesicle exocytosis. Using a combination of in silico and physicochemical approaches and a new experimental device mimicking synaptic conditions, we show that serotonin aggregates are efficiently dissolved by gangliosides (especially GM1) present in postsynaptic membranes. This initial interaction, driven by electrostatic forces, attracts serotonin from insoluble aggregates and resolves micelles into monomers. Serotonin also interacts with cholesterol via a set of CH-π and van der Waals interactions. Thus, gangliosides and cholesterol act together as a functional serotonin-collecting funnel on brain cell membranes. Based on this unique mode of interaction with postsynaptic membranes, we propose a new model of serotonergic transmission that takes into account the post-exocytosis solubilizing effect of gangliosides and cholesterol on serotonin aggregates.
Historical Blurry Video-Based Face Recognition
Authors: Zhai Lujun , Cui Suxia , Wang Yonghui , Wang Song , Zhou Jun , Wilsbacher Greg
Published: September 2024

Face recognition is a widely used computer vision, which plays an increasingly important role in user authentication systems, security systems, and consumer electronics. The models for most current applications are based on high-definition digital cameras. In this paper, we focus on digital images derived from historical motion picture films. Historical motion picture films often have poorer resolution than modern digital imagery, making face detection a more challenging task. To approach this problem, we first propose a trunk–branch concatenated multi-task cascaded convolutional neural network (TB-MTCNN), which efficiently extracts facial features from blurry historical films by combining the trunk with branch networks and employing various sizes of kernels to enrich the multi-scale receptive field. Next, we build a deep neural network-integrated object-tracking algorithm to compensate for failed recognition over one or more video frames. The framework combines simple online and real-time tracking with deep data association (Deep SORT), and TB-MTCNN with the residual neural network (ResNet) model. Finally, a state-of-the-art image restoration method is employed to reduce the effect of noise and blurriness. The experimental results show that our proposed joint face recognition and tracking network can significantly reduce missed recognition in historical motion picture film frames.
Comparing Implant Macrodesigns and Their Impact on Stability: A Year-Long Clinical Study
Authors: Popovski Julie , Mikic Mirko , Tasevski Dimitar , Dabic Sasa , Mladenovic Rasa
Published: September 2024

Background and Objectives: The aim of this study was to clinically evaluate the primary and secondary stability of dental implants with different macrodesigns using resonance frequency analysis and to determine whether implant design and length influence implant stability. Materials and methods: This study included 48 healthy patients receiving dental implants, and a pre-implant planning protocol was used, which involved detailed bone analysis, clinical examinations, and Cone beam computed tomography (CBCT) analysis. The implants were of various types and dimensions (Alpha-Bio Tec (Israel), DFI, SPI, and NEO), and the surgical procedures were performed using standard methods. Implant stability was measured using resonance frequency analysis (RFA) immediately after placement and after 3, 6, and 12 months. The total number of implants placed in all patients was 96. Results: The average primary stability value for 10 mm SPI implants placed in the maxilla was 68.2 ± 1.7 Implant Stability Quotient (ISQ) units, while for 10 mm NEO implants, it was 74.0 ± 0.9. The average primary stability value for a 10 mm DFI implant placed in the mandible was 72.8 ± 1.2 ISQ, while for a 10 mm NEO implant placed in the mandible, it was 76.3 ± 0.8 ISQ. Based on the Friedman ANOVA test, the differences in the stability measurements for the 10 mm and 11.5 mm SPI implants and for the 10 mm and 11.5 mm NEO implants in the maxilla on day 0 and after 3, 6, and 12 months were significant at p < 0.05. Similarly, based on the Friedman ANOVA test, the differences in the stability measurements for the 10 mm and 11.5 mm DFI implants and for the 10 mm and 11.5 mm NEO implants in the mandible on day 0 and after 3, 6, and 12 months were significant at p < 0.05 (p = 0.00000). Conclusions: Universal tapered implants of the NEO type stood out as the optimal choice, as they provided statistically significantly higher primary stability in both soft and hard bone types compared to other implants. The implant length did not significantly affect this stability.
Functional Mobility and Balance Confidence Measures Are Associated with Disability among Community-Dwelling Older Adults
Authors: Alhwoaimel Norah A. , Alshehri Mohammed M. , Alhowimel Ahmed S. , Alenazi Aqeel M. , Alqahtani Bader A.
Published: September 2024

Background and Objectives: Our objectives were to examine the association between balance confidence, functional mobility measures, and the presence of disability in older adults in Saudi Arabia and to identify the optimal cutoff scores for these measures that predict disability. Materials and Methods: A cross-sectional study was conducted among 324 community-dwelling older adults (65 ± 7 years, 59% women). Disability was assessed using the Arabic version of the basic activities of daily living (ADLs) scale. Balance confidence was evaluated using the Arabic version of the Activities -Specific Balance Confidence (ABC) scale, and functional mobility was assessed using the 30-Second Chair Stand Test (30s-CST). Results: The prevalence of disability was 33.6% among the participants. Logistic regression revealed a 6% increase in disability odds for each one-unit decrease in the 30s-CST (OR: 0.94) and a 3% increase per one-point decrease in the ABC score (OR: 0.97). The optimal cutoff scores were ≤5 repetitions for the 30s-CST (sensitivity: 74.4%; specificity: 51.4%; AUC: 0.64) and ≤40 for the ABC scale (sensitivity: 80.8%; specificity: 61.4%; AUC: 0.75). Conclusions: Impaired balance and functional mobility are significantly associated with disability among older adults. The 30s-CST and the ABC scale can be used as effective screening tools, but the cross-sectional design of the current study limits its generalizability. Longitudinal research is needed to validate these findings.
The Wedding and Its Medialization from the Perspective of the Ljubljana Lacanian School
Authors: Löffler Paul
Published: September 2024

The ritual of marriage serves as a nexus for various dimensions of social and personal life, including sexuality, gender, religiosity, family, and parenthood. This pivotal event is laden with a multitude of expectations, hopes, and fears for all involved parties. The psychological energies converge not only within the spouses or participants but extend to encompass the entire cultural community. Simultaneously, it represents a ritualistic identification, where individuals, through the ritual, become what they are, establishing an identity. This article aims to provide a Lacanian interpretation of the marriage ritual, informed by the interpretation popularized by the Ljubljana school of psychoanalysis. Lacan’s framework allows for the conceptualization of identification as a socially mediated process, revealing the psyche as extending beyond the individual into intersubjective structures. This approach might help to clarify the inner logic of the ritual, allowing for a better understanding of the role of medialization. It will be shown, that under these lenses wedding photography and other forms of medialization do not only preserve memories of the event afterward but are already playing an active and even constitutive role during the event.
The Introduction of Same-Sex Marriage in Germany—A Question of Conscience and/or Faith? A Case Study
Authors: Exner-Krikorian Sabine
Published: September 2024

On 30 June 2017, the German Bundestag voted in favor of the introduction of marriage for same-sex couples—a historic moment. Only a few days earlier, the then Federal Chancellor Angela Merkel had released the vote as a decision of conscience and thus dissolved the usual underlying factional compulsion—does this mean that rights for homosexual people are a question of personal conscience and values? Such a localization arouses the interest of religious studies to investigate how the discourse actors from the fields of politics, church and society formulate the decision of conscience as a discursive strategy in the negotiation process of same-sex marriage in Germany argumentatively and which positionings as well as descriptions of others and themselves are derived from this. The starting point is a modernity in which the actors move, understand and articulate themselves. This understanding of modernity is based on the process of a vertical transfer (Gladigow) of sociological theories of religion, among others, whereby narratives of secularization, overcoming religion (as a necessary precondition of modernity) and narratives of an opposition of religious vs. secular or religious vs. homosexual reappear as positions and arguments in the discourse. Using the approach of discursive religious studies (von Stuckrad) in conjunction with sociological discourse analysis (Keller), these processes of positioning, demarcation and negotiation based on the premises of modernity will be analyzed for the period from 2013 to 2017 on the basis of the public debate on religious, political, and social actors in Germany.
Leveling Up: Gamification Pedagogy in the Hagiological Classroom
Authors: Massad Alexander E.
Published: September 2024

Gamification is a specific type of experiential learning theory (ELT) that emphasizes student choice and activities to transform mundane tasks into a desirable opportunity to learn. This pedagogical approach is particularly useful in information-heavy courses, such as courses that engage in the study of religious mysticism or “hagiology”. In hagiology classes, students are exposed to new hagiographic media and discuss methods that are particularly complicated because this content is not only heavy on data but also engages the affective dimensions of human experience. This article explores leessons learned from the successes and failures of gamification pedagogy in my “Masters and Mystics” course, where students comparatively study Christian mysticism and Muslim Sufism. In particular, this article analyzes gamifacation’s ability to promote intrinsic student motivation through “game mechanics and experience design”, which is particularly salient in the hagiological classroom. I end the article with a discussion of how I have reworked the course with new gamification practices into a “Comparative Mysticism: Christianity and Islam” course.
Think Vibrio, Think Rare: Non-O1-Non-O139- Vibrio cholerae Bacteremia in Advanced Lung Cancer—A Case Report
Authors: Marino Andrea , Cacopardo Bruno , Villa Laura , D’Emilio Adriana , Piro Salvatore , Nunnari Giuseppe
Published: September 2024

Vibrio cholerae, a Gram-negative bacterium, is widely known as the cause of cholera, an acute diarrheal disease. While only certain strains are capable of causing cholera, non-O1/non-O139 V. cholerae strains (NOVC) can lead to non-pathogenic colonization or mild illnesses such as gastroenteritis. In immunocompromised patients, however, NOVC can cause severe infections, including rare cases of bacteremia, especially in those with underlying conditions like liver disease, hematologic disorders, and malignancies. This case report presents a rare instance of NOVC bacteremia in a 71-year-old patient with advanced lung cancer, illustrating the clinical presentation, diagnostic challenges, and treatment interventions required. The patient presented with fever, asthenia, and confusion, and was found to have bacteremia caused by NOVC, confirmed through blood cultures and molecular analysis. Treatment with intravenous ceftriaxone and ciprofloxacin led to a rapid clinical improvement and resolution of the infection. This case, along with an overview of similar incidents, underscores the importance of considering NOVC in differential diagnoses for immunocompromised patients presenting with fever, and highlights the necessity of timely diagnosis and targeted antimicrobial therapy to achieve favorable outcomes.
Highly Efficient Oxygen Electrode Design for Anion-Exchange Membrane-Unitized Regenerative Fuel Cells
Authors: Park Ji Eun , Choi Hyuck Jae , Choi Hee Ji , Na Geumbi , Park SungBin , Lee Kyung Ah , Yeom Kyungbeen , Cho Yong-Hun , Sung Yung-Eun
Published: September 2024

Designing highly efficient oxygen electrodes is crucial for the development of anion-exchange membrane-unitized regenerative fuel cells (AEM-URFCs) that operate in both water-electrolysis (WE) and fuel-cell (FC) modes. In this article, we introduce a suitable oxygen electrode design that includes oxygenevolution-reaction (OER) and oxygen-reduction-reaction (ORR) catalysts that exhibit high WE and FC performance. We first investigated three different oxygen electrodes, one with a single layer comprising a mixture of two catalysts, and the others with dual layers comprising separate layers. The AEMURFC with the ORR catalyst as the inner layer and the OER catalyst as the outer layer exhibited excellent WE and FC performance, leading to high round-trip efficiencies. In addition, the effects of the OER- and ORR-catalyst loadings on the oxygen electrode were examined. The resulting optimal AEM-URFC yielded the highest round-trip efficiency of 62% at 20 mA cm−2 among researched AEM-URFCs. In addition, the developed AEM-URFC exhibited durable WE and FC performance over 50 h.
Discoloration of triphenylmethane Dyes in Ethylene Glycol-Water Coolant Medium
Authors: Choi Ye Won , Raheem Abbasriyaludeen Abdul , Park Se Jeong , Park Ji Min , Lee Gaeun , Lee Seungwook , Park Jong S.
Published: September 2024

Aluminum (Al) alloys find extensive application in vehicle cooling systems due to their favorable strength balance, lightweight properties, thermal conductivity, and corrosion resistance. The combination of AlF3-KF, named flux, is crucial in protecting Al surfaces during brazing processes. Despite the prevalent usage of ethylene glycol-based coolant (EG-coolant) due to its cost-effectiveness and stability, concerns arise concerning side reactions affecting corrosion resistance. This study investigates the impact of EG coolant and Alflux on the discoloration of a blue-colored coolant with triphenylmethane (TPM) dye through simulated conditions. UV-Vis spectral analysis reveals the interaction between Al and flux, suggesting their synergistic effect on coolant color changes. The discoloration mechanism of TPM dye in the presence of Al is proposed through NMR analysis. Furthermore, XPS and SEM analysis are employed to observe the corrosion phenomena on the Al surface, tracking the corrosion behaviors concerning the interaction with the coolant. The findings indicate that the addition of Al and flux to the coolant leads to Al corrosion, resulting in the formation of Al(OH)3 and subsequent chemical interactions, which produce KOH within the coolant. Lastly, we explore methods to manage Al corrosion and alleviate TPM color changes by evaluating the effect of additives on the coolant composition. The current findings offer insights into potential modifications in the composition of Al-flux cooling systems, offering valuable insights into system performance without requiring additional instrumentation.
Prescribing practices for Proton pump inhibitors among primary care physicians in England
Authors: Plehhova Kate , Wray Joshua , Aluko Patricia , Sutton Scott , McArdle Jim , Dawson Anne , Coyle Cathal , Stevens Richard M
Published: September 2024

Background

Proton pump inhibitors (PPIs) the most frequently prescribed drug class globally, are often overused.

Aim

To assess PPI prescribing practice in England.

Design & setting

Electronic medical record (EMR) evaluation from 62 primary care GP practices.

Method

Adult patients on continuous PPI treatment (repeat prescription or≥4 acute prescriptions 6 months before data extraction) were included (August 2021−June 2022) to compare PPI prescribing practices vs National Institute for Health and Care Excellence (GORD and dyspepsia management) and Medicines and Healthcare products Regulatory Agency (clopidogrel-PPI interaction) guidelines.

Results

We identified 77,356 patients on continuous PPI treatment. The most common (68%) diagnosis recorded in patients’ EMRs and indicated for PPI use was gastroprotection, although 62% had no recorded indication. Of these 62% patients, 40% had no medication review in the preceding year. Among those with diagnoses indicated for≤3 months of PPI therapy (34%), 99% received their first PPI prescription≥3 months previously. Of patients with diagnoses indicated for long-term treatment (4%), 41% had no medication review in the preceding year. Furthermore, 18% of patients using omeprazole or esomeprazole were also prescribed clopidogrel, and 19% of those prescribed treatments associated with gastrointestinal risk (N=14,826) were not prescribed PPIs.

Conclusion

This study shows that PPI prescribing in England is not in alignment with existing clinical guidelines and highlights the need for appropriate measures to increase awareness of overuse and support deprescribing where appropriate.
Complicações pós-operatórias do transplante hepático
Authors: Carvalho Alice Cassiano de Sousa , Arruda Eduardo Henrique Bianchesi Pires de , Souza Letícia Araujo de , Oliveira Lucas da Silva , Simoni Luiza Machado Xavier , Rivero Murilo Coelho Nogueira , Gagliardi Valentina Silva , Corrêa Wagner Pablo
Published: September 2024

Este traballho descreveu sobre o transplante hepático (TH) e suas principais complicações pós-operatórias. O TH é uma forma de tratamento para pacientes com hepatopatias graves e insuficiência hepática severa, que é a 11ª principal causa de mortalidade mundial. Este procedimento visa substituir um fígado doente por um saudável, buscando restaurar a funcionalidade hepática e melhorar a qualidade de vida. Contudo, o TH é complexo e está associado a diversas complicações tanto imediatas quanto tardias. Complicações imediatas incluem problemas vasculares, biliares, infecciosos e rejeição do enxerto, que tem elevada morbimortalidade. A longo prazo, a terapia imunossupressora pode causar complicações adicionais como insuficiência renal crônica, hipertensão arterial, diabetes mellitus, dislipidemia e maiore riscos de malignidades. Apesar desses desafios, o TH tem mostrado melhorias significativas na qualidade de vida dos pacientes, com benefícios físicos e sociais.
Desafios na saúde LGBTQIA+: a prevalência de comorbidades psiquiátricas na população LGBTQIA+
Authors: Almeida Nathalya Karen Silveira de , Lavoratti Anna Claudia , Sarolli Maria Eduarda Bedin , Nascimento Samila Carla da Silva , Ferreira Bianca Knieling
Published: September 2024

A saúde LGBTQIA+ ainda representa um desafio para a gestão pública, considerando o arcabouço histórico rico em preconceitos e estigmas que precedem o atual contexto . Desse modo, por meio de uma revisão integrativa de natureza qualitativa, objetivou-se analisar as principais comorbidades psiquiátricas que afetam essa população, identificando as prevalentes, como forma de guiar futuras intervenções. Desse modo, foram analisados os estressores específicos das minorias sexuais, qual a situação do acesso à saúde por esse público e as principais comorbidades psiquiátricas que os afetam. A partir dos resultados, identificou-se que a inserção da população em um ambiente hostil à sua sexualidade e identidade de gênero, que sofre com a invisibilidade, preconceito, violência, bem como com a falta de acesso adequado à saúde, é potencialmente danosa, sendo identificados como prevalentes os distúrbios psiquiátricos: depressão, ansiedade e ideação suicida, que foram citadas em 5 artigos cada, abuso de drogas em 4 artigos, estresse, estresse pós-traumático e autoagressão em 2 artigos cada e distúrbios alimentares, paranóia e agorafobia em 1 artigo cada. Diante disso, restou evidenciada a necessidade ampliação do cuidado por meio de políticas de afirmação de gênero e profissionais qualificados, hábeis a atender as necessidades específicas dessa população.
العوامل المؤثرة في خصائص مجلس الإدارة في الشركات العائلية المساهمة المصرية
Authors: زيدان عمرو علاء الدين
Published: September 2024

سعت هذه الدراسة للتعرف إلى خصائص مجلس الإدارة في الشركات العائلية المساهمة المصرية. وفى سبيل ذلك، قام الباحث بمراجعة الدراسات السابقة التي تصدت لحوكمة الشركات وخصائص مجلس الإدارة في البيئات الغربية. واعتمدت الدراسة على ثمانية فروض بحثية تختبر تأثير كل من: العمر التنظيمي، والحجم التنظيمي، والأجيال المالكة، والأجيال المديرة في الشركات العائلية المساهمة المصرية في تطور هيكل (تشكيل) مجلس الإدارة، وتطور أدوار مجالس الإدارة، وتطور أدوار رؤساء مجالس الإدارة في هذه الشركات. واعتمد الباحث على عينة مكونة من (88) شركة عائلية مساهمة مصرية، وعلى قائمة استقصاء نمطية لجمع بيانات الدراسة من وحدات المعاينة في هذه الشركات. واستخدم الباحث مجموعة من الأساليب الإحصائية متعددة المتغيرات في تحليل بيانات الدراسة. وانتهت الدراسة إلى عدم تأثير المتغيرات التنظيمية (العمر التنظيمي والحجم التنظيمي) في الجوانب المختلفة لمجلس الإدارة في الشركات العائلية المساهمة المصرية، وأن المتغيرات الجيلية (عدد الأجيال المالكة وعدد الأجيال المديرة) هي صاحبة التأثير المعنوي في تطور الجوانب المختلفة لمجلس الإدارة في هذه الشركات. واختتمت الدراسة بمناقشة النتائج ودلالاتها، كما قدم الباحث المجالات البحثية التي تتطلب مزيدا من الدراسة في هذا المجال.
Teacher Training at Math Club
Authors: da Silva Maria Marta , Francisco Alves Lukas Adriel
Published: September 2024

The article aims to investigate how the planning of teaching activities based on the historical movement of the process of emergence and development of mathematical concepts by a collective of Mathematics teachers in initial training contributed to the understanding that these concepts are a product of the humanitie needs and that the organization of Mathematics teaching in schools must address this understanding. Related to this objective, we sought to answer the following question: What contributions can a training space called the Mathematics Club bring to the initial training of Mathematics teachers? In the search for answers to this problem and to achieve the objective, the formative experiment was chosen as research methodology, happening from 2020 to 2023. The data analysis structure chosen was: unit, episodes and flashes. The results shows that teachers were able to establish a historical understanding of the concepts that were approached.
A Neural Networks and Rules based System used to Find a Correlations, and Therefore Try to Maintain the State of Health, in Patient Affect by Multiple Sclerosis at the Origins of Well-Being at a Certain Time Daily Time with Clinical and the Musculoskeletal Exams
Authors: Francesco Pia Prof. PhD Eng.
Published: September 2024

In this work we will explore the fact that according to recent studies published in specialist medical journals, during the early morning sleep-wake hours, during the early morning sleep-wake hours. The idea we propose is the clinical-musculoskeletal monitoring of a certain number of MS patients for twenty-four hours so that they can collect data to train a neural network with an appropriate learning algorithm suitable for the purpose. The patients will first be hypothesized as such in the present work and in the subsequent ones a virtual patient will be developed, only in the last step will real patients be used whose data will be housed in the virtual container necessary to be able to present it to the learning system.
Kirchliche Bildung mit Kindern und Jugendlichen
Authors: Schlag Thomas , Lorenzen Stefanie , Greuter Fabienne , Held Felicitas , Voirol-Sturzenegger Rahel , Zurgilgen Karina
Published: September 2024

Welche religionspädagogischen Angebote gibt es im reformierten Kontext der Schweiz? Was sind die Erwartungen von Kindern, Jugendlichen, Mitarbeitenden sowie Eltern? Was die Erfahrungen? Die dritte internationale Studie zur Konformationsarbeit untersucht genau dies für die Schweiz und berücksichtigt dabei sowohl die Primarstufe als auch die Konfirmationsarbeit. Überlegungen zum eigenen Glauben, zu Themeninteressen, Methoden, Digitalisierung und kirchlicher Partizipation rücken in den Fokus. Da das Forschungsprojekt während der Corona-Pandemie durchgeführt wurde, stellt die Studie auch ein Zeitzeugnis kirchlicher Bildungsarbeit während der Pandemie dar und beleuchtet ganz generell Tendenzen und Entwicklungstrends kirchlicher Bildungsarbeit mit Kindern und Jugendlichen.
Rate of Weak Convergence of Random Walk with a Generalized Reflecting Barrier
Authors: Gever Başak , Khanıyev Tahir
Published: September 2024

In this study, a random walk process with generalized reflecting barrier is considered and an inequality for rate of weak convergence of the stationary distribution of the process of interest is propounded. Though the rate of convergence is not thoroughly examined, the literature does provide a weak convergence theorem under certain conditions for the stationary distribution of the process under consideration. Nonetheless, one of the most crucial issues in probability theory is the convergence rate in limit theorems, as it affects the precision and effectiveness of using these theorems in practice. Therefore, for the rate of convergence for the examined process, comparatively simple inequality is represented. The obtained inequality demonstrates that the rate of convergence is correlated with the tail of the distribution of ladder heights of the random walk.
Management Control System and Firm Performance in Nepalese Commercial Bank
Authors: Upadhyay Jitendra Prasad , Singh Sanju Kumar , Panthi Suresh
Published: September 2024

This study focused on the interplay of control levers and organizational learning as well as the impact of Management Control Systems (MCS) on firm performance in Nepalese Commercial Banks. The study aims to examine the relationships between MCS levers (belief, boundary, diagnostic, interactive) and firm performance and assess the mediating role of organizational learning in this relationship. The study was done using descriptive and causal-comparative design, where a survey was carried out by deriving the responses from the employees of various commercial banks in Kathmandu. The findings of the study highlighted the significant correlations between MCS, organizational learning, and performance, highlighting MCS as a key tool for enhancing performance in the Banking sector. This study acknowledges limitations such as focusing only on Kathmandu and suggests future research to expand geographically and explore other sectors for broader applicability.
Keywords: Management Control Systems, Levers of Control, Organizational Learning, Banking Sector.e other sectors for broader applicability.
RESEARCH ON THE MECHANISM OF RESILIENT LEADERSHIP'S EFFECT ON THE RESILIENCE OF SMALL TOURISM ENTERPRISES
Authors: Liu Shan , Du Yifei
Published: September 2024

Tourism, as a strategic pillar industry in our country, is critical in promoting economic development and labor employment. During the "Fourteenth Five-Year Plan" period, China will fully enter the era of mass tourism. This study focuses specifically on small tourism enterprises. Based on a review of the resilience of domestic and foreign enterprises, guided by relevant theories such as dynamic capability theory and resource allocation theory, and on the basis of redefining the concept connotation and extension of small tourism enterprises' resilience, tenacious leadership, inter-organizational learning, resource restructuring and environmental complexity, This paper builds a theoretical model based on the influence mechanism of resilient leadership and resilience of small tourism enterprises, describes and statistically analyzes the basic characteristics, current situation and existing problems of resilience of small tourism enterprises, and uses case analysis and empirical analysis methods to explore the impact degree and impact path of resilient leadership on resilience of small tourism enterprises. Finally, the study proposes measures to boost the resilience of small tourism enterprises, drawing from the findings of case and empirical analysis.
CAN TASTE AND PRESENTATION OF RESTAURANT MENUS CHANGE CUSTOMERS' HEALTH KNOWLEDGE AND PERCEPTIONS? A NATURAL RESTAURANT FIELD EXPERIMENT
Authors: Manasoontorn Rapeepat , Sattayathamrongthian Mahachai , Sumatapiwat Suradat , Tongniam Wipawan
Published: September 2024

This study examines the impact of menu taste and presentation on customers’ health knowledge and perceptions using behavioral economics in a restaurant setting. The increasing prevalence of non-communicable diseases (NCDs) and obesity highlights the importance of dietary choices for health outcomes. Using a natural field experiment involving 349 participants in Chiangmai, Thailand, this study examines how experiments taste and alterations in menu design, specifically through convenience and visibility interventions, can encourage healthier meal selections. The experiment shows that taste significantly influences the perception of meal healthiness, while strategic menu presentation influences customers' meal choices and their ability to accurately estimate caloric content. The findings suggest that making high-calorie options more visible tends to lead participants towards choices with higher caloric content than estimated, indicating the potential of menu design in modifying consumer behavior towards healthier eating habits. Additionally, the study examines demographic factors such as age, gender, and Body Mass Index (BMI), alongside self-reported dietary practices, to understand their influence on meal selection decisions. This study contributes to behavioral economics by providing empirical evidence on how small changes in the food environment can promote healthier diets, addressing the global challenge of tackling non communicable diseases and obesity.
RUSSIA’S ENERGY DIPLOMACY TOWARD EUROPEAN UNION IN THE 21STCENTURY AND IMPACT OF CONFLICT IN UKRAINE
Authors: Yi He , Withitwinyuchon Nutthathirataa , Somboon Vira
Published: September 2024

In the 21st century, the importance of energy as an important strategic resource in the international market has been rising. As a traditional energy export country, Russia's abundant fossil fuel resources are the foundation for its energy diplomacy. Energy issues play an important role in the relationship between Russia and the European Union, and the interdependence between Russia and the EU in the energy sector is strong. Russia and the European Union have made several achievements in the energy field, including establishing an energy dialogue and cooperation mechanism and building multiple energy transportation pipelines. However, there are still some conflicts and contradictions in energy cooperation between Russia and Europe. Ukraine, as a major transit country for Russia to transport energy to the European Union, has caused geopolitical conflicts that hinder energy cooperation between Russia and Europe. The ongoing conflict in Ukraine has further worsened the energy relationship between Russia and the European Union. The EU has raised sanctions against Russia in the energy sector, and accordingly, Russia implemented counter-sanctions measures. In this situation, the EU is attempting to reduce its reliance on Russia’s energy by diversifying its energy resources, which puts the energy relationship between the two sides at risk of decoupling. Russia has begun to adjust its energy diplomacy strategy, shifting its focus from traditionally predominantly Western countries to the East.
THE REGIONAL COMPREHENSIVE ECONOMIC PARTNERSHIP (RCEP) AGREEMENT AND ITS IMPLICATIONS ON TRADE BETWEEN EU-27 AND RCEP-15
Authors: Fauzel Sheereen , Gunnoo Leenshya
Published: September 2024

This paper investigated the impact of the RCEP on trade between RCEP-15 and EU-27. The static framework has been used. The empirical evidence is based on the Random Effect estimation and the models shows that while economic growth in RCEP-15 may reduce trade with EU-27, the RCEP negotiations does not have the same effect. The results show that the RCEP negotiations has resulted in an increase in trade between RCEP-15 and EU-27. The interactive term between the RCEP and GDP shows that together these two variables still lead to an increase in trade between RECP-15 and EU-27.
THE USE OF GAME TEACHING METHOD FOR CHINESE SPEAKING SKILL OF GRADE 5 STUDENTS IN CHACHOENGSAO PROVINCE, THAILAND
Authors: Wang Yinuo , Sakulwongs Nipaporn
Published: September 2024

This study aimed to compare the Chinese speaking skills of grade 5 students before and after using the game teaching method, as well as assess their satisfaction with its use in a Chinese speaking course. The participants consisted of 41 Thai students in Grade 5 in Chachoengsao Province, Thailand. We collected data using four lesson plans, a pre-test, a post-test, and a questionnaire, and used descriptive statistical analysis and paired sample mean differences for analysis. A school in Chachoengsao Province conducted the teaching experiment and collected the data over a four-week period. Pre-test and post-test results showed a significant improvement in participants' Chinese speaking skills, with a mean difference of 3.53 points between pre-test scores (=16.02, SD=2.49) and post-test scores (=12.49, SD=2.57). All items in the questionnaire received high ratings, according to the collected data from the questionnaire. The majority of participants expressed satisfaction with the application of the game teaching method to Chinese-speaking learning. This study demonstrated that the game teaching method provided an alternative and effective way of learning Chinese in Thailand.
AN INTEGRATION OF LABOV'S NARRATIVE ANALYSIS MODEL TO CONTINUATION WRITING INSTRUCTIONAL DESIGN
Authors: Bao Yan
Published: September 2024

The modern Chinese educational framework increasingly prioritizes critical thinking, creativity, and practical communication skills, recognizing writing as fundamental beyond test performance. Continuation writing, which involves extending a given story, requires students to deeply understand the original text and develop coherent, stylistically consistent continuations. Traditional product-oriented writing instruction separates reading from writing, focusing on the final product and using scores to assess rather than instructing on revisions. This approach tends to lead to student disinterest and passive attitudes towards writing, with compositions revised only for grammatical errors instead of cohesive and coherent content organization. This study highlighted the development of a continuation writing instruction based on Labov's Narrative Analysis Model, guided by sociocultural theory. We implemented the model with 30 senior high school students in Heilongjiang province, China, and collected data to assess the students' needs in terms of complexity, accuracy, and fluency (CAF). The results indicated students' needs in four areas: understanding the article's theme and structure, extracting critical information, organizing and planning, and enhancing style and creativity. Pedagogically, the study offers valuable insights for teachers and students. Teachers gain guidance on integrating Labov's model to nurture students' narrative competence and writing proficiency. Students benefit from a better understanding of their continued writing needs.
UMBLE LEADERSHIP PERSPECTIVE ON CREATIVE PERFORMANCE: THE MEDIATING ROLE OF PSYCHOLOGICAL SAFETY CLIMATE AND THE MODERATING EFFECT OF LMX
Authors: Tao Rongdi
Published: September 2024

This study aimed to investigate how humble leadership influences creative performance by mediating the psychological safety climate and the moderating role of leader-member exchange (LMX). We hypothesized that humble leadership could positively foster a psychological safety climate, thereby enhancing creative performance, and that LMX would strengthen this positive effect of humble leadership.
Using quantitative research methods, this study surveyed 684 ordinary white-collar employees in China and analyzed the collected data using structural equation modeling and multiple linear regression. Overall, the results supported all of the hypotheses. Humble leadership had a positive effect on both psychological safety climate and creative performance. There was also a positive effect on psychological safety climate and creative performance. Finally, psychological safety climate acted as a mediator between humble leadership and creative performance. When LMX levels were high, the positive effect of humble leadership on psychological safety climate became more noticeable. The conclusions of this study indicate that humble leadership is an effective means to promote employees' creative performance as it operates through shaping a psychologically safe work environment, while high-quality LMX relationships can further enhance this effect.
RESEARCH ON THE INFLUENCE OF BIG DATA ANALYTICS CAPABILITY ON AMBIDEXTROUS INNOVATION IN MANUFACTURING ENTERPRISES
Authors: Tang Haige , Zhao Jianyu
Published: September 2024

This paper, based on the perspectives of dynamic capabilities theory, constructs a theoretical model to explore the mechanisms by which big data analytics capabilities influence ambidextrous innovation in manufacturing enterprises. We conducted a survey among mid- to senior-level managers of manufacturing firms in the Yangtze River Delta region of China to empirically test this model, yielding 586 valid samples. We analyzed the questionnaire data using PLS-SEM. The research results show that big data analytics capabilities have a significant positive impact on ambidextrous innovation in manufacturing firms. Additionally, resource bricolage plays a partial mediating role in the relationship between big data analytics capabilities and ambidextrous innovation. These findings provide theoretical guidance for manufacturing enterprises to promote ambidextrous innovation through the development of big data analytics capabilities.
Ізоморфізм комутативних гіперкомплексних числових систем і представлення експоненціальних функцій у них
Authors: Каліновський Я. О. , Синькова Т. В. , Муратова М. О.
Published: September 2024

Розглянуто можливість використання представлень експоненціальних функцій для дослідження ізоморфізму гіперкомплексних числових систем.