bluuebunny/crossref_metadata_2025 huggingface dataset:
Euphorbia tirucalli elicitora EM CULTIVO DE Vigna unguiculata: BIOPROCESSO, BIOPRODUTO E POTENCIAL BIOTECNOLÓGICO DIGESTOR PLÁSTICO
Authors: De Souza Nicole Delaunay , Silva Felipe Freire Souza , Gaspar Sandra Ávila , Gorini Claudia Correia , Varricchio Marcia Cristina Braga Nunes , Pyrrho Alexandre dos Santos , Brioso Paulo Sérgio Torres , Da Silva Simone
Published: October 2023

Tendo em vista a preocupação mundial com os resíduos plásticos persistentes no meio ambiente, o presente estudo busca alternativas de reuso e reaproveitamento para diminuir a poluição, por meio de extratos dos espécimes de Euphorbia tirucalli. O método envolveu a coleta de látex de diferentes regiões geográficas e a avaliação dos efeitos corrosivos e de retração de extratos vegetais aquosos sobre o polipropileno. Os resultados indicam variações na capacidade dos extratos de interagir com o plástico, com alguns apresentando efeitos de digestão ao longo do tempo. Esta abordagem, explorando a ação enzimática e corrosiva dos extratos de Euphorbia tirucalli, sugere o potencial bioeconômico para a digestão de plásticos não degradáveis ao longo do tempo. O estudo também ressalta a importância da bioengenharia como uma abordagem inovadora para resolver problemas ambientais. A pesquisa destaca a relevância da busca por soluções sustentáveis para a gestão dos resíduos plásticos, visando promover a sustentabilidade ambiental e mitigar os impactos ambientais. Embora sejam necessárias pesquisas mais aprofundadas, para entender os mecanismos de ação dos extratos de Euphorbia tirucalli e sua viabilidade em larga escala, essa abordagem oferece perspectivas bioeconômicas promissoras para a biodegradação de plásticos persistentes na natureza e a valorização de comunidades étnicas que já praticam esses preceitos. Em resumo, o estudo destaca a importância de explorar alternativas naturais para lidar com a poluição plástica e contribuir para a conservação do meio ambiente.
Analisis Tingkat Kepuasan Pengguna Aplikasi Wifi TB dengan Metode Delon and Mclean
Authors: Fitriana Imelda , Singasatia Dayan , Kaniawulan Ismi
Published: September 2023

Pengguna aplikasi Wajib Notifikasi tuberkulosis (Wifi TB) diimplementasikan di lingkungan Klinik Kabupaten Purwakarta. Pada penelitian ini dilakukan penyebaran kuesioner pra penelitian yang digunakan sebagai data pendukung penelitian yang disebarkan kepada Petugas di lingkungan Klinik Kabupaten. ditemukan beberapa permasalahan yang dirasakan oleh pengguna Wajib Notifikasi Tuberkulosis (Wifi TB). Permasalahan yang dirasakan oleh pengguna saat mengakses Wajib Notifikasi Tuberkulosis (Wifi TB) antara lain, terdapat fitur dalam sistem yang tidak berfungsi dengan baik, Sering terjadinya server yang down, Sistem yang kurang responsive, Tampilan kurang menarik dan susah dipahami, Tidak user friendly, Pengguna merasa sistem susah dioperasikan. Hal ini pada akhirnya mengarah pada tingkat kepuasan yang berbeda untuk setiap pengguna. Tujun Penelitian untuk menguji faktor apa saja yang dapat mempengaruhi kepuasan pengguna Aplasi Wajib Notifikasi Tuberkulosis (Wifi TB). Model penelitian yang digunakan adalah DeLone & McLean Penelitian ini pengolahan datanya menggunakan aplikasi SPSS versi 26.0 dan IBM SPSS dan SmartPLS 4. Hasil penelitian ini yaitu hipotesis ke-1 Service Quality (SQR) berpengaruh positif dan signifikan terhadap User Satisfaction (US), hipotesis ke-2 Sistem Quality (SQ) berpengaruh positif dan signifikan terhadap User Satisfaction (US), hipotesis ke-3 Information Quality (SQL) berpengaruh positif dan signifikan terhadap User Satisfaction (US) hipotesis ke-4 User Satisfaction (US) berpengaruh positif dan signifikan terhadap Net Benefit (NB).
Filmes mucoadesivos na saúde
Authors: Gomes Taleessa Vieira , Clemente Vitória Batista , Polo Ana Barbara , Fabri Rodrigo Luiz , Tavares Guilherme Diniz , Apolônio Ana Carolina Morais
Published: September 2023

Os filmes mucoadesivos são um modelo de entrega de fármacos que podem ser utilizados em mucosas bucal, nasal, ocular, gastrointestinal e retal. Por serem não-invasivos e fáceis de serem administrados, eles promovem uma maior adesão do paciente ao tratamento proposto. A composição e estrutura dos filmes desempenham papel importante em sua funcionalidade e eficácia, sendo no geral compostos de polímeros mucoadesivos, substancias bioativas, adjuvantes e excipientes. A característica fundamental destes filmes é a mucoadesão. Ela confere aos filmes adesão à mucosa, proporcionando a liberação local ou sistêmica do fármaco. Várias teorias para a mucoadesão têm sido propostas e são apresentadas neste capítulo. Apesar disso, outras propriedades desses filmes como as biológicas (como biodisponibilidade, biocompatibilidade, atividade citotóxica e atividade antimicrobiana), e as físico-químicas (como espessura, elasticidade e permeabilidade) também são importantes e devem ser consideradas para se mensurar a eficácia e segurança dos mesmos. Essa forma farmacêutica tem sido estudada para diversas modalidades de tratamento, como tratamento de câncer, em terapias de úlceras, disfunções hormonais, diabetes, doença periodontal e outros. Portanto, tornam-se essenciais estudos contínuos sobre o tema, a fim de se obter novas formulações e, portanto, alternativas farmacêuticas.
Levantamento da herpetofauna em reserva legal na cidade de Colorado do Oeste Rondônia
Authors: Souza Jucelino Santos de , Almeida José Elias de
Published: September 2023

O Brasil possui a maior riqueza de anfíbios no mundo, com 1.080 espécies atualmente reconhecidas, pertencentes a três Ordens: 1.039 Anura (sapos, rãs e pererecas), 5 Caudata (salamandras) e 36 Gymnophiona (cobras-cegas e cecílias), sendo que muitas espécies novas foram descritas nos últimos anos (ICMBio, 2018). O território Brasileiro tem a terceira fauna de répteis mais rica do planeta, com 795 espécies: 36 Testudines, 6 Crocodylia e 753 Squamata, (Costa & Bérnils 2018), ficando atrás da Austrália (1.057) e do México (942). No estado de Rondônia existem poucas pesquisas com informações sobre inventários e biologia de anfíbios. Dentre os estudos desenvolvidos em Rondônia, destaca-se o trabalho de VANZOLINI (1986) que apresentou uma lista de anfíbios e répteis através de coletas ao longo da BR-364. Na Amazônia é encontrada uma grande riqueza de anfíbios, entretanto, em algumas regiões ainda são pouco conhecidas. Este estudo teve como objetivo apresentar um inventário de anfíbios e repteis de uma área de fragmento de floresta secundária na reserva de um sitio no Município de Colorado do Oeste, localizado no estado de Rondônia. A coleta de dados ocorreu entre os meses de março de 2020 a agosto de 2020, sendo utilizado quatro métodos de amostragem, procura limitada por tempo, armadilhas de interceptação e queda, encontros ocasionais e vocalização. Foram registradas 19 espécies de anuros distribuídos em sete famílias. Hylidae e Leptodactylidae foram às famílias com maior número de espécies encontradas. Já os repteis foram encontradas 5 espécies em cinco famílias.
Educação internacional e os entraves dos brasileiros
Authors: Costa Julianne Dutra da
Published: September 2023

A educação é importante não apenas para aqueles que fazem parte de uma única nação, mas também se faz extremamente relevante aos olhos dos outros países, a fim de permitir que ocorra um relacionamento de escala internacional, a partir da troca de culturas, estudantes e profissionais de mercado, fazendo-se necessária para que se construa uma boa relação.
The use of the pdca cycle and the 5W2H tool as quality control tools by school management
Authors: Sena Willame Nogueira de
Published: September 2023

The school is the space where administrative and pedagogical aspects intersect. Therefore, it should imprint on the subjects productive and critical administrative-pedagogical experiences. For the school to be aligned with these principles and the objectives that underlie them, school management needs to assimilate quality tools so that the execution of its role is positive. Given the above, the present work aims to reflect on the importance of quality tools in school management and suggest the use of the PDCA cycle in conjunction with the 5W2H tool. The bibliographic review technique was selected as a research method, unfolding on texts that expand the initial debate on the theme of quality in management processes at school. At first, data collection was performed using the descriptors “quality management in education”, “quality control tools in education”, “PDCA cycle” and “5W2H tool” on the Google Scholar platform. Different combinations of these descriptors were used through the Boolean operators “OR” and “AND” to obtain a more specific result. The analysis of the results was carried out through the synthesis of the information contained in the selected articles, with the aim of presenting a broad and objective view of the proposed theme. Finally, we reached an understanding of the relevance of quality control tools for school management, here more specifically the PDCA cycle added to the 5W2H tool, playing a fundamental role in the administrative and pedagogical organization of the school institution, with positive effects on the processes that develop within it.
The influence of infant death on the nurse's experience: Reflections in the light of phenomenology
Authors: Silva Jéssica Íris Franco da , Silva Hallyson Leno Lucas da , Carneiro Shayanna Mickaela Duque , Alencar Isabele Gouveia Muniz de , Medeiros Katarine Florêncio de , Araújo Rhayssa de Oliveira e , Oliveira Jonas Sâmi Albuquerque de
Published: September 2023

There are numerous positive and negative factors that influence the experience of nurses, especially those of a psychic and/or emotional nature, which can manifest themselves in various ways in the professional and even personal trajectory. To understand this experience in pediatric intensive care settings, appropriating the systematics involved in the relationship with children and families, it is necessary to reflect on the influence that infant death can have on this work. This study aimed to reflect on the influence of infant death on the experience of nurses, in the light of phenomenology. This is a qualitative study of the reflective essay type, with phenomenological inspiration, using aspects of the works of Merleau-Ponty, carried out from a dialogue between the scientific literature and the critical analysis of the authors. Each person experiences particular perceptions and sensations, including in the reality of intensive care settings. Professionals acquire special meanings in professional and personal life, because they are prepared for everyday situations of their work, and still have the opportunity to reflect on this world that surrounds them. The reflections demonstrated how the experiences with death infer values to the social role that the nurse routinely translates, considering her humanized attitude as a principle very well applied in reality, and how this set of her various perceptions and sensations have repercussions on the care provided.
Chess game as an educational aid in the pedagogical process, for learning and motivation
Authors: Ferreira João Henrique de Freitas
Published: September 2023

This investigative study aims to investigate the experience of using the game of chess as a pedagogical didactic resource, in the facilitation of learning and school motivation, through the chess project in the state school Helena Pugó, school where the study was conducted, with the high school students of this school in the municipality of Recife of the state of Pernambuco, Brazil. With this work, we sought to know what influence the game of chess may have provided in the learning and school motivation of students of the 3rd (third) year of high school, showing the benefits that this seemingly simple game had its contribution, helping in school performance and student performance. The methodology of the study used was of a qualitative nature, as it is more appropriate and indicated for this educational investigation, with better application results. The data collection instruments used were, for the participating students, a semi-structured questionnaire applied by the researcher, and for the participating teachers, an interview with the investigator. The research showed that the practice of students with the game of chess provided all the benefits narrated in the theoretical framework, such as the improvement of reasoning, memorization, concentration, attention, decision making, among other qualities that chess stimulates in its practitioners, helping to improve learning and school motivation of students and, consequently, school performance and educational success as a whole.
Bacillus subtilis as a growth promoter of forest species seedlings
Authors: Chagas Junior Aloisio Freitas , Martins Albert Lennon Lima , Chagas Lillian França Borges , Giongo Marcos , Silva Damiana Beatriz da , Sousa Kellen Angela O. de , Rocha Adilon Martins , Moura Dallila Moreira de Oliveira , Almeida Leticia Bezerra de , Souza Bruna Marques de
Published: September 2023

Native forest species have been employed for several purposes, such as the recovery of degraded areas, reforestation, and afforestation. The growth-promoting microorganisms are a viable alternative to producing native forest seedlings. The Bacillus subtilis is an alternative since it stands out by promoting plant growth through the solubilization of phosphate, production of phytohormones, and the availability of nutrients. The present work aimed to evaluate the influence of Bacillus subtilis in the initial growth of fava-tamboril (Enterolobium maximum), amarelão (Apuleia leiocarpa), and paricá (Schizolobium amazonicum) seedlings. Inoculations were made with two strains of Bacillus subtilis (Bs08, Bs10) and the commercial product based on Bacillus subtilis PANTA©, using 1 mL of the solution of each strain, and a control sample with water only, using a graduated pipette. An entirely randomized design with three treatments and eight repetitions was used. The variables analysed were plant height (PH), stem diameter (SD), root volume (RV), root dry weight (RDW), above-ground biomass weight (AGB), and Dickson quality index (DQI). In general, inoculation with Bacillus subtilis, with both strains evaluated and the commercial inoculant (PANTA ©), provided gains in biomass and in the DQI of plants at 30 and 60 days after emergence. Thus, the inoculation of Bacillus subtilis showed promising results as a growth promoter for paricá, fava-tamboril, and amarelão.
Therapeutic Recreation: A Bibliometric Analysis from the Web of Science (WoS) Database
Authors: CAN GABERLİ Yağmur
Published: October 2023

Bu çalışma, terapötik rekreasyon üzerine yayınlanmış çalışmaların bibliyometrik analizini yapmayı amaçlamaktadır. Başlığında “terapötik rekreasyon” geçen yayınlar Web of Science veri tabanında taranmıştır. Web of Science veri tabanı tercih edildiğinden araştırma bulguları bu veri tabanı ile sınırlıdır. Ancak tarama işlemi sırasında herhangi bir alan filtrelemesi yapılmamıştır. İlki 1980 yılında olmak üzere toplam 216 yayına ulaşılmıştır. Yayınların menşe ülkeleri incelendiğinde en çok Amerika Birleşik Devletleri, Kanada ve Avustralya kaynaklı olduğu tespit edilmiştir. Yaşlı ve engelli nüfus oranının her geçen gün artması nedeniyle gelecekte ilgili çalışmaların sayısının arttırılması beklenmektedir.
Edukasi Stunting pada Ibu Balita
Authors: Heryani Heni , Istikharoh Istikharoh , Sari Meylinda , Yulansari Mirna , Putri Gustin Monica
Published: September 2023

Introduction The prevalence of stunting in Indonesia in 2022 is 21.6%, while in Ciamis in 2021 it is 16%, this figure has not reached the national target of 14%. This is a very serious problem that needs to be dealt with quickly and precisely. One of the factors causing stunting is the lack of knowledge about efforts to prevent stunting from an early age. The impact of stunting is very dangerous for the survival of children in the future. One of the efforts to prevent stunting that can be done is to provide education about efforts to prevent stunting.

Objective: The purpose of this community service is to increase the knowledge of mothers of toddlers about stunting, with the target of mothers of toddlers who come to Posyandu Dusun Desa Kulon, Cijeungjing Ciamis.

Method: The method used in this service is the provision of education about stunting through the media of leaflets.

Results: The results of the service show that the average pretest result is less knowledgeable by 65%, and after education, the average knowledge is sufficient by 60.5%.

Conclusion: Stunting education using leaflet media can increase the knowledge of mothers under five as an effort to prevent stunting.
Penerapan Pendampingan Ibu Hamil Oleh Kader Kesehatan Dengan Metode “Siska” Satu Ibu Satu Kader Sebagai Upaya Peningkatan Kualitas Kesehatan Ibu Hamil
Authors: Kurniawati Anik , Handayani Rohmi
Published: September 2023

Introduction: Upaya menurunkan Angka Kematian Ibu dan Angka Kematian Bayi membutuhkan peran serta lintas sektor. Kader merupakan pembawa misi pembangunan kesehatan ditingkat paling bawah. Sampai saat ini kader kesehatan terkadang menjadi sumber rujukan bagi penanganan berbagai masalah seorang kesehatan. Proses pendampingan ibu hamil memang dilakukan oleh bidan desa, namun demikian dalam menggerakkan masyarakat tidak terlepas dari peran kader sebagai orang yang membawa misi kesehatan yang terdekat dengan masyarakat.
Objective: 1. Meningkatkan pengetahuan kader tentang pendampingan ibu hamil dengan metode SISKA (satu Ibu satu kader); 2. Meningkatkan kemampuan kader dalam pendampingan ibu hamil dengan metode SISKA ( satu ibu satu kader )
Method: pres test dilakukan sebelum diberikan pendidikan kesehatan, kemudian dilanjutkan dengan pendidikan kesehatan, demonstrasi serta melakukan praktik langsung deteksi dini risiko tinggi ibu hamil. Setelah itu akan dilakukan post test. Tahap kedua melakukan pendampingan kepada ibu hamil mulai Trimester III yaitu umur kehamilan 28 minggu sampai 40 minggu. Selanjutnya di lakukan pendampingan lagi setelah bersalin yaitu pendampingan pada masa nifas yang dilakukan dengan frekuensi sebanyak 3 kali.
Result: Hasil post test menunjukkan bahwa Jumlah kader dengan pengetahuan baik meningkat dari 80% menjadi 90 %, sebagian kader  (90%) telah melaksanakan pendampingan sesuai dengan pedoman.
Conclusion: Pengetahuan kader meningkat setelah mendapatkan pendidikan edukasi tentang metode SISKA, serta kader telah dapat memberikan pendampingan pada ibu hami, bersalin dan nifas sesuai dengan pedoman.
Analysis of Beginning Stage of Reading Skills of First Grade Students of Indriasana Palembang Primary School.
Authors: Indriasari Indriasari , Krisnandi Ignasius Firdo
Published: October 2023

This study aims to describe the beginning stage reading ability of first grade students at SD Indriasana Palembang. This research method is descriptive qualitative, with data collection through observation, interviews, tests, and documentation. The sample used saturated sampling technique. The research sample was 61 first grade students at SD Indriasana Palembang. The results of the study, first in the aspect of reading letters as much as 98% of respondents achieved the criteria of "very good" and 2% achieved "good". Second, in the aspect of reading syllables, 98% of respondents with the criteria of "very good" and 2% "enough". Third, in the aspect of reading words 92% of respondents with the criteria of "very good" and 8% "enough". Fourth, in the aspect of reading sentences 84% ​​of respondents with "very good", 11% "good", and 5% "enough".
Role of Nutraceuticals in Control of Hypertension: A Review
Authors: Habibi Munquad , Shankarishan Priyanka
Published: September 2023

Nowadays, hypertension is of utmost concern in both developing and developed countries, since it leads to many health problems like cardiovascular disease, heart attack, and stroke. In recent years, many studies were conducted to investigate the effect of nutraceuticals on blood pressure, which are natural food components having pharmacological properties. Nutraceuticals are especially beneficial for pre-hypertensive patients having a little more blood pressure than the normal range, in association with positive lifestyle changes. Even though nutraceuticals have a blood pressure-lowering effect, they cannot replace the conventional method of drug treatment for patients suffering from high blood pressure. Nutraceuticals with blood pressure-lowering activity under different categories like food, nutrients, and non-nutrients are reviewed in this article.
FRACTIONAL INTEGRATIONS FOR THE NEW GENERALIZED HYPERGEOMETRIC FUNCTIONS
Authors: Chaudhary M. P. , Kaurangini M. L. , Kiymaz I. O. , Abubakar U. M. , Ata E.
Published: October 2023

In this article, authors discussed about image formulas for the some new extended hypergeometric function using elementary properties of the fractional calculus integral operators. Furthermore, using integral transforms some image formulas are also established.
Vulnerability Assessment of Emerging Infectious Diseases in Davao City, Southern Philippines: Utilizing Global Predictors to Develop Localized Interventions
Authors: Damgo Marie , Bacus Michael , Bernido Jan Danelle , Evangelio Sherelyn , Ligue Kim Dianne , Estaña Leo Manuel , dela Torre Von Carlo , Murao Lyre Anni , Alviola Pedro
Published: September 2023

Emerging infectious diseases (EIDs) – influenced by socioeconomic, environmental, andecological factors – pose a significant threat to both global economies and public health.Multiple EIDs have emerged in the 21st century, including the current coronavirus disease(COVID-19) pandemic associated with a novel severe acute respiratory syndrome coronavirus2 (SARS-CoV2). Understanding the factors contributing to the emergence of EIDs is crucialfor mitigating its risks and preventing disease outbreaks that could escalate into epidemics andpandemics. Thus, this study developed a scoring index that could estimate the vulnerability ofan area concerning the emergence of novel EIDs using established global predictors – whichinclude socio-economic and demographic factors (population density, housing, and businesspermits), weather variables (humidity, precipitation, and temperature), animal hosts (livestockand domestic animal populations), and wildlife-livestock-human interfaces (wet markets,urban green spaces, and commercial animal farms). Davao City, located in the Southern partof the Philippines, was used as a study site, wherein its barangays represent the smallest unitof geopolitical communities. Barangays vulnerable to EIDs were determined based on theresulting EID index. Clustering of vulnerability index scores across communities was identifiedusing the Global Moran’s I and Getis-Ord General G statistic. The Getis-Ord Gi* and AnselinLocal Moran’s I were then used to identify the hotspot barangays most vulnerable to EIDs. Themost vulnerable areas to EIDs were barangays with larger urban green spaces and a highernumber of commercial animal farms and wet markets in Davao City. These most vulnerablebarangays were also clustered and located in the districts of Toril, Tugbok, and Calinan. Hence,an appropriate basic action plan for these most vulnerable barangays should be provided.Moreover, policies related to wildlife management and urban planning should be revisited,with emphasis on mitigating the risks (i.e. infectious disease surveillance, zoning, animal biosecurity, and sanitation and hygiene) associated with EIDs while giving equal importancetoward maintaining a stable local economy.
In Vitro Assessment of the Inhibitory Effect of Sludge against Fusarium oxysporum f. sp. cubense (Smith) Synder et Hansen
Authors: Francisco Jessica , Guzman Maria Aileen Leah , Tan Gana Neil , Unson Jewel Racquel , Espiritu Emilyn , Gulpeo Pia Clarisse , Sandoval Aurea Marie
Published: September 2023

Sludge production is a major challenge for wastewater treatment plants and is expected to exceed10,000 tons per day worldwide. Inadequate management of sludge can result in treatment and disposal issues, necessitating the need for effective sludge disposal strategies. Recent studies have shown that sludge may be effective in controlling soil-borne pathogens, but the underlying mechanisms and potential applications of this property in local environments remain unclear.To address this knowledge gap, this study investigated the physico-chemical properties of sludge from a sewage treatment plant and its inhibitory activity against the fungal pathogen Fusarium oxysporum. Sludge samples produced at various drying rates were tested, and the percent relative inhibition zone diameter (% RIZD) was measured. Potential bacterial species with inhibitory properties were isolated from the sludge and identified, and correlational analysis was carried out. The results show that sludge extract, after two months of drying, had the highest % RIZD(78.29 ± 5.7%, p < 0.05) – which correlated positively with the total bacterial count, total nitrogen, potassium, and microbial respiration. These results indicate that the biotic components may have a positive effect on the sludge's inhibitory potential against F. oxysporum. Although sludge has been found to have the potential to inhibit fungal pathogens, further treatment is necessary to meet regulatory standards (PNS/BAFS 40:2016) and avoid environmental contamination. This study provides a baseline for future research on sludge reuse and management policies.
Simulated Docking of alpha-Conotoxin Interactions with Nicotinic Acetylcholine Receptors
Authors: Bascos Neil Andrew , Acda Ron Michael , Bautista Clarence Lei , Jimenez Elsie
Published: September 2023

The nicotinic acetylcholine receptors (nAChRs) are linked to several biological processes and neurological conditions. The α-conotoxins represent an essential resource for ligands with which to explore structure-function correlations for a variety of nAChR subtypes. With the multitude of nAChR subtypes occurring in vivo, it is imperative to search for subtype-selective ligands to effectively utilize their modulatory functions for their target receptors. In this work,docking simulations using PatchDock showed that either the replacement of Ala10 with the more hydrophobic Leu in PnIA to PnIA[A10L] or the presence of a sulfated tyrosine in the structural scaffold of PnIA[Y15Y] or PnIB[Y15Y] (Y stands for sulfated tyrosine) is sufficient to alter the interactions of α-conotoxins PnIA and PnIB for their target nAChR receptor subtypes – α7and α3β2. The employed protocol can be utilized to screen for ligand docking and amino acid residue interactions of α-conotoxins to certain nAChR subtypes. This was tested on α-conotoxinLoIA, which was predicted to preferentially bind to the α3β2 nAChR over α7 nAChR. The present work is supportive of the idea that the conserved α-conotoxin structural scaffold can be further investigated to guide the synthesis of novel nAChR ligands with greater specificity.The results of this study will be useful in the rational design of selective nAChR antagonists for potential peptide therapeutics.
Community-Academic Partnership in Action: Results of a Pilot Diabetes Intervention Program in Rural Southern Philippines
Authors: Candelario Cristela Mae , Bandala-Dingal JC Louise , Misoles Melvin , Cuajotor Josephine
Published: September 2023

The increasing prevalence of diabetes in the Philippines is a growing public health concern,especially among prediabetic individuals lacking knowledge and awareness about the disease.This study evaluated the effectiveness of a 6-mo community-based health program in a rural area of southern Philippines. The pilot intervention comprised comprehensive learning modules, lectures, discussions, exercises, personalized nutrition counseling, and house-to-house monitoring visits conducted by healthcare professionals affiliated with a higher education institution (HEI), in collaboration with community leaders and health workers. Twenty-two (22) adults with hyperglycemia were enrolled in the study, and their knowledge, attitude, and practices were evaluated before and after the intervention. The majority of participants were aged over 50 (90.91%), were female (86.36%), were married (95.45%), had completed secondary education (50.00%), and were unemployed (59.09%). The results indicated a significant improvement in participants' knowledge (p < 0.001) and practices (p = 0.019). However, the study revealed that attitudes remained predominantly neutral, suggesting challenges in adapting to the condition (p = 0.266). This study underscores the significance of community-academic partnerships and the engagement of community health workers in fostering sustainable health promotion initiatives. Future research endeavors could explore the integration of diverse health promotion strategies to enhance positive attitudes toward diabetes management. The findings of this study can provide valuable insights for larger-scale multisectoral investigations, as well as inform the development of effective and tailored diabetes prevention and management programs in the Philippines and worldwide.
Bacterial and Fungal Community Profiling of Karst Ecosystem in Basey, Samar, Philippines Using Shotgun Metagenomic Approach
Authors: Ong John Daniel , Geronimo Edmerson , Bosito Eula Francia , Villarama Kristiann Gabriele , Lara Zachary , Querubin Florabelle , Balolong Marilen
Published: September 2023

The Philippines has an abundance of karst or forest over limestone landscapes, but only a small percentage of them have been studied and protected. Although the flora and fauna of karst forests are diverse and unique, little is known about the microflora that inhabits this ecosystem. The taxonomic and functional composition of bacteria and fungi in soil samples from three locations within three karst forest zones in Basey, Samar, Philippines were analyzed using Illumina shotgun metagenome sequencing. Proteobacteria and Actinobacteria bacterial sequences were most prevalent in the karst soil, followed by those of the Firmicutes, Acidobacteria, Chloroflexi, Planctomycetes, Cyanobacteria, Verrumicrobia, Bacteriodetes, and Deinococcus-Thermus. The most abundant fungal sequences belonged to Ascomycota, followed by Basidiomycota. An average of 33 million predicted protein features was detected across all sites. Enzyme pathways for nitrogen and sulfur metabolism, and several carbon fixation pathways, appeared nearly complete. To our knowledge, this is the first report to provide baseline information on the microbial community and their possible roles in karst forest ecosystem health in the Philippines, which may lead to identifying new microbes with specialized metabolism and promoting biodiversity conservation of karst forests in the Philippines. Furthermore, correlation analysis with plant diversity will reveal plant-microbe interaction leading to the understanding of the adaptation, abundance, survival, and diversity of microorganisms and plants.
Perceptions and Determinants of Consumers' Willingness to Buy (WTB) Fermented Rice Bran-enriched Beverages in Eastern Visayas, Philippines
Authors: Dalin-as Dianne , Abilgos-Ramos Riza , Caña Angelita
Published: September 2023

Rice bran contains health-beneficial components, which are enhanced during the fermentation process. Fermented rice bran (FRB) can be used as an adjunct ingredient to enhance the nutritional value of foods. The study aimed to assess the perceptions and determinants of consumers’ willingness to buy (WTB) FRB-enriched beverages in Eastern Visayas, Philippines.A face-to-face survey was conducted with 402 respondents, which was proportionally distributed in the six provinces of Eastern Visayas. Descriptive analysis was used to analyze the respondents’ socio-demographic characteristics, awareness, perceptions, and WTB FRB-enriched beverages.Binary logistic regression analysis was employed to analyze the factors affecting the willingness of the consumers to buy FRB-enriched beverages. Results revealed that almost all respondents were unaware (96%) of FRB and FRB-enriched beverages, which could be primarily because using FRB in food applications is a new concept in the Philippines. In spite of their high level of unawareness, they generally had positive perceptions of FRB-enriched beverages such as being healthy and nutritious and having a good taste. Many also were willing to buy FRB-enriched beverages when made available in the market. Regression analysis showed that married couples were 0.61 less likely to buy FRB-enriched beverages than single and widow/widower individuals.Those who are aware of FRB-enriched beverages were 2.77 times more likely to buy FRB-enriched beverages than those who are not aware. Likewise, the odds that the consumers who are aware of FRB and its health benefits will buy the product was 3.41 times more than those who are not aware. Further results revealed that consumers who perceived that FRB-enriched beverages have good taste were 3.58 times more likely to buy the product than those individuals who perceived that the products do not have a good taste.
Isolation of Nanocellulose by Enzymatic Hydrolysis of Bleached Musa textilis (Abaca) Pulp
Authors: Balagot Kim Wilmer , Delica Kimberly , Lapuz Rebecca , Lapuz Anniver Ryan , Ramos Rowena , Domingo Emmanuel
Published: September 2023

Nanocellulose is commonly isolated from cellulosic materials by chemical methods using strong acids. In this study, the enzymatic method was explored to isolate nanocellulose from commercial bleached S 2 grade abaca pulp. It was first disintegrated for 10 min and was subjected to enzyme hydrolysis while incubated with Bacillus sp. cellulase for 72 h at 50 °C and 120 revolutions/min. A clear liquid material was obtained after enzymatic hydrolysis after a series of centrifugation and ultrasonication. Results showed that the isolated nanocellulose had an average particle size of 375.9 nm ± 2.9 with a polydisperse index of 0.404 ± 0.059. Transmission electron and atomic force images showed that nanocellulose was longitudinal in size and highly aggregated and agglomerated. Through FTIR analysis, crystallinity indexes (i.e. lateral order index, total crystallinity index, and hydrogen bond intensity) of bleached abaca pulp and the isolated nanocellulose were compared. Results showed that the enzymatic hydrolysis of bleached abaca pulp resulted in higher cellulose crystallinity. Overall, nanocellulose can be isolated using biological methods using Bacillus sp. cellulase. These results could be used as a baseline to isolate smaller particle sizes, highly monodisperse, and stable nanocellulose that could be further applied in packaging, papermaking, cosmetics, medicine, and numerous other applications.
Exhaustive Review on Nail Lacquer in the Treatment of Nail Diseases
Authors: Chauhan Ayushi , Nainwal Nidhi , Butola Mansi , Jakhmola Vikash
Published: September 2023

The delivery of drugs through the transungual route is necessary because many nail diseases such as onychomycosis, psoriasis, paronychia, and onycholysis require topical drug delivery through the nail plate to avoid the systemic side effects of drugs first-pass hepatic metabolism and to provide direct benefits at the site of disease. However, topical delivery is associated with the main drawback of poor permeability of drugs through the nail plate. The nail plate contains tight networks of cross-linked protein (keratin) that provide hardness to the nail. Successful permeation of drugs through this nail barrier can be achieved by mechanical or chemical approaches. The chemical methods (penetration enhancers) are mainly associated with the disruption of nail integrity. Nail lacquers are the most popular dosage form from the formulation viewpoint. As the solvent evaporates, lacquers create polymeric drug-loaded films on the nail tissue that have a high concentration of the drug and allow for prolonged contact with the tissue. The present article focuses on the emergence of nail lacquers as prospective transungual delivery systems for the treatment of various mild to moderate nail diseases.
Endophytic Fungal Species Isolated from Mangrove Trees Rhizophora apiculata, Nypa fruticans, and Xylocarpus granatum from Brunei Darussalam
Authors: Mohamad Nur Azyyati Haziqah , Taha Hussein , Shivanand Pooja , Ahmad Norhayati , Abdillah Anis Nadiah , Alias Muhammad Azib , Mohaimin Abdul Zul’adly , Krishnamoorthy Sarayu
Published: September 2023

An attempt made to isolate the mangrove endophytes from Rhizophora apiculata, Nypa fruticans, and Xylocarpus granatum has shown the presence of about 28 different strains of endophytic fungi belonging to the phyla Ascomycota. Rhizophora apiculata was found to possess highly diverse endophytic species compared to Nypa fruticans and Xylocarpus granatum. Furthermore, the leaves of the mangrove trees were found to serve as a rich source of endophytic fungal species compared to other segments studied. Moreover, it was observed that the leaf acted as a major source of endophytic fungi in Rhizophora apiculata and Nypa fruticans, whereas barks were found to have a high number of species in Xylocarpus granatum.
SHIKSHAK PRABHAVSHILTA AUR KAKSHA PRAVANDHAN MAEN BHAVNATMAK BUDHIMATTA KI BHUMIKA
Authors: Dr Uday Pratap Singh
Published: September 2023

Education is important in society as it influences the educational and cultural development of students. Teacher effectiveness refers to their skill in connecting with students through emotional, supportive, and positive interactions. Emotional intelligence improves student effectiveness. Emotional intelligence is developed and maintained through attention, perception, intelligence, awareness, and attention. Emotional intelligence allows a person to understand themselves and the people around them and makes interactions with their peers more enjoyable and enriching. Emotional intelligence helps people to understand and develop their feelings, emotions, sensations, and sensibilities.
Gambaran penggunaan obat dengan aktivitas psikotik pada pasien di praktik dokter “X” kota Tarakan periode Oktober-Desember 2021
Authors: Ilham Ilham , Syuhada Syuhada , Rukaya Benazir Evita
Published: October 2023

Tingginya angka kejadian gangguan jiwa dikalangan masyarakat meningkatkan pula penggunaan obat-obat antipsikotik dalam penanganannya. Salah satu fasilitas kesehatan dasar di Tarakan yang melayani konsultasi masalah kejiwaan adalah praktik dokter “X”. Tujuan penelitian ini adalah untuk mengetahui gambaran penggunaan obat-obatan antipsikotik yang digunakan pada praktik dokter “X” di Tarakan. Metode penelitian yang digunakan adalah deskriptif retrospektif dengan mengkaji resep pasien yang mengandung obat-obat dengan aktivitas psikotik pada praktik dokter “X” di kota Tarakan periode Oktober-Desember 2021, penetapan sampel data penelitian menggunakan metode purposive sampling. Hasil penelitian menunjukkan obat-obat antipsikotik yang digunakan adalah risperidone, chlorpromazine, clozapine, escitalopram, fluoxetine, olanzapine, sertraline, maprotilin, aripiprazole, haloperidol, quetapine fumarate, sedangkan obat-obat anxiolityc adalah lorazepam, diazepam, clobazam, alprazolam, chlordiazepoxide, clonazepam, nitrazepam. Kesimpulan penelitian ini adalah peresepan obat psikotik tertinggi diberikan pada pasien Middle-age adults (42,29%), jumlah obat yang diperoleh pasien sebesar 2,6 obat per pertemuan, persentase obat generik yang diresepkan sebanyak 27%, dan pesentase frekuensi pemberian tertinggi berdasarkan kelas terapinya yaitu risperidon (19,7%) dan lorazepam (11,64%).
Integration of Machine Learning and Structural Analysis for Predicting Peptide Antibiofilm Effects: Advancements in Drug Discovery for Biofilm-Related Infections
Authors: Ebrahimi Tarki Fatemeh , Zarrabi Mahboobeh , Abdiali Ahya , Sharbatdar Mahkame
Published: September 2023

Background: The rise of antibiotic resistance has become a major concern, signaling the end of the golden age of antibiotics. Bacterial biofilms, which exhibit high resistance to antibiotics, significantly contribute to the emergence of antibiotic resistance. Therefore, there is an urgent need to discover new therapeutic agents with specific characteristics to effectively combat biofilm-related infections. Studies have shown the promising potential of peptides as antimicrobial agents. Objectives: This study aimed to establish a cost-effective and streamlined computational method for predicting the antibiofilm effects of peptides. This method can assist in addressing the intricate challenge of designing peptides with strong antibiofilm properties, a task that can be both challenging and costly. Methods: A positive library, consisting of peptide sequences with antibiofilm activity exceeding 50%, was assembled, along with a negative library containing quorum-sensing peptides. For each peptide sequence, feature vectors were calculated, while considering the primary structure, the order of amino acids, their physicochemical properties, and their distributions. Multiple supervised learning algorithms were used to classify peptides with significant antibiofilm effects for subsequent experimental evaluations. Results: The computational approach exhibited high accuracy in predicting the antibiofilm effects of peptides, with accuracy, precision, Matthew's correlation coefficient (MCC), and F1 score of 99%, 99%, 0.97, and 0.99, respectively. The performance level of this computational approach was comparable to that of previous methods. This study introduced a novel approach by combining the feature space with high antibiofilm activity. Conclusions: In this study, a reliable and cost-effective method was developed for predicting the antibiofilm effects of peptides using a computational approach. This approach allows for the identification of peptide sequences with substantial antibiofilm activities for further experimental investigations. Accessible source codes and raw data of this study can be found online (hiABF), providing easy access and enabling future updates.
Apreciación de artículos científicos sobre la evaluación clínica del Trastorno del Espectro Autista en el continente americano
Authors: Yepez Navedo Marina
Published: September 2023

El objetivo de este estudio es proporcionar información detallada sobre los diagnósticos clínicos de Trastorno de Espectro Autista que se han realizado recientemente para detectar de manera puntual avances, así como también áreas de oportunidad. Para ello se empleó una investigación documental en la que se seleccionaron y analizaron 16 artículos científicos publicados en el continente americano que trataban exclusivamente del diagnóstico clínico del TEA basado en la última edición del Manual de diagnóstico estadístico de los trastornos mentales (DSM-5). Los resultados cualitativos muestran que la mayoría de las publicaciones científicas relacionadas con el diagnóstico clínico del TEA se realizan en los Estados Unidos, siendo el diagnóstico en edad tempranas el tema más estudiado.
Spazio e produzione vitivinicola in Italia dall’Unità a oggi. Tendenze e tappe principali.
Authors: Bonardi Luca
Published: October 2023

Questo articolo presenta una sintesi dell’evoluzione dello spazio vitivinicolo italiano, e della sua produzione, dalla seconda metà dell’Ottocento ai giorni nostri. E’ nel corso di questi 150 anni che i territori a destinazione vitivinicola del Paese vanno assumendo, pur mantenendosi evidenti alcuni elementi di continuità con le diverse eredità pre-unitarie, quei caratteri che ne contraddistinguono la dimensione, quantitativa e qualitativa, attuale. Attraverso l’analisi delle tappe fondamentali di tale percorso, si metteranno a fuoco le fasi più problematiche, le costanti e alcune tendenze di medio e lungo termine di una delle attività economiche maggiormente rappresentative dell’Italia nel mondo.
Relapse of Pheochromocytoma with Hipertensive Heart Disease Mildly Reduced Left Ventricle Ejection Fraction
Authors: Filianty Sipayung Merylla , Kusnadi Yulianto , Shahab Alwi , Maila Dewi Ratna , Soleh Imran , Pramudhya Hoesain Fadil
Published: October 2023

Pheochromocytoma is a tumor originating from the medulla of the adrenal gland. This tumor is rare and is caused by excessive production of catecholamines. There are three classic triads of pheochromocytoma: diaphoresis, palpitations and headaches. Elevated metanephrines and normetanephrine in plasma or urine confirm the diagnosis. At the same time, radiological examination helps in the tumor's location and the presence of local invasion or metastasis. Hypertension is a health problem that is quite dangerous worldwide because it is a significant risk factor for cardiovascular diseases such as heart attack, heart failure, stroke, and kidney disease. Hypertension can cause Hypertensive Heart Disease, which is a significant cause of morbidity and mortality due to cardiovascular disease. This scientific report presents a case study of a 19-year-old woman diagnosed with relapsed pheochromocytoma and hypertensive heart disease with mildly reduced left ventricular ejection fraction. This patient was previously diagnosed at the age of 13 with pheochromocytoma, where the patient experienced symptoms of headache, sweating, especially in the forehead area, trembling hands, and hypertension. Hence, the patient had to be treated. The patient underwent further examination and found a right adrenal tumor, so an adrenalectomy was performed on the patient. Similar complaints appeared again in the patient, and further examination was carried out. Moreover, an increase in plasma metanephrine and normetanephrine levels was found. A CT scan of the abdomen revealed a right adrenal tumor, so this patient underwent another adrenalectomy.
ANALISIS PSIKOLOGI ISLAM TENTANG KETAHANAN MENTAL PADA INDIVIDU YANG MENGHADAPI STIGMA AGAMA
Authors: Nafsaka Sajidin Zayin , Kambali Kambali , Ahmad Ridwan Wawan , Widya Astuti Aurelia , Sayudin Sayudin
Published: September 2023

Stigma agama seringkali menjadi tekanan psikologis yang signifikan bagi individu yang menganut keyakinan agama tertentu. Penelitian sebelumnya telah menunjukkan bahwa stigma agama dapat berdampak negatif pada kesejahteraan mental individu, tetapi masih sedikit penelitian yang secara khusus menggali faktor-faktor psikologis yang dapat membantu individu dalam menghadapi stigma agama. Penelitian ini bertujuan untuk menganalisis psikologi Islam dalam konteks ketahanan mental individu yang menghadapi stigma agama. Pendekatan psikologi Islam digunakan sebagai kerangka analisis untuk memahami dan mengembangkan pemahaman tentang ketahanan mental individu yang menghadapi stigma agama. Metode penelitian yang digunakan adalah analisis kualitatif dengan melakukan wawancara mendalam terhadap individu yang menghadapi stigma agama. Partisipan penelitian dipilih secara purposif dengan mempertimbangkan variasi latar belakang agama dan pengalaman dalam menghadapi stigma. Data yang terkumpul dianalisis dengan menggunakan pendekatan tematik untuk mengidentifikasi pola-pola, tema-tema, dan perspektif-perspektif yang muncul dalam wawancara. Hasil penelitian ini memberikan wawasan yang mendalam tentang faktor-faktor psikologis yang berkontribusi pada ketahanan mental individu yang menghadapi stigma agama. Temuan menunjukkan bahwa penggunaan prinsip-prinsip Islam seperti tawakkal (mengandalkan diri sepenuhnya pada Allah), sabar, dan ikhtiar (usaha maksimal) dapat memainkan peran penting dalam membantu individu mengatasi stigma agama. Selain itu, dukungan sosial dari komunitas agama, peningkatan pemahaman tentang agama, dan pengembangan identitas keagamaan yang kuat juga terbukti berperan dalam meningkatkan ketahanan mental individu. Temuan ini memiliki implikasi praktis dalam pengembangan intervensi psikologis yang sensitif secara agama untuk membantu individu mengatasi stigma agama dan meningkatkan kesejahteraan mental mereka.
The Difference-to-Inference Model for Values in Science
Authors: Stegenga Jacob , Menon Tarun ,   Saint Louis University
Published: October 2023

The value-free ideal for science holds that values should not influence the core features of scientific reasoning. We defend the difference-to-inference model of value-permeation, which holds that value-permeation in science is problematic when values make a difference to the inferences made about a hypothesis. This view of value-permeation is superior to existing views, and it suggests a corresponding maxim—namely, that scientists should strive to eliminate differences to inference. This maxim is the basis of a novel value-free ideal for science.