bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation Miner: Mining Business Process Models and Event Correlations Without Case Identifiers
Authors: Pourmirza Shaya , Dijkman Remco , Grefen Paul
Published: May 2017

Process discovery algorithms aim to capture process models from event logs. These algorithms have been designed for logs in which the events that belong to the same case are related to each other — and to that case — by means of a unique case identifier. However, in service-oriented systems, these case identifiers are rarely stored beyond request-response pairs, which makes it hard to relate events that belong to the same case. This is known as the correlation challenge. This paper addresses the correlation challenge by introducing a technique, called the correlation miner, that facilitates discovery of business process models when events are not associated with a case identifier. It extends previous work on the correlation miner, by not only enabling the discovery of the process model, but also detecting which events belong to the same case. Experiments performed on both synthetic and real-world event logs show the applicability of the correlation miner. The resulting technique enables us to observe a service-oriented system and determine — with high accuracy — which request-response pairs sent by different communicating parties are related to each other.
China’s Macroeconomic Fundamentals on Stock Market Volatility: Evidence from Shanghai and Hong Kong
Authors: Cheng Andy Wui Wing , Yip Iris Wing Han
Published: May 2017

This paper examines the effect of Chinese macroeconomic variables, the industrial production growth rate, the producer price index, the 3-month short-term Shanghai Interbank Offer Rate and the consumer price index, on the volatility of the Shanghai and Hong Kong stock markets. We apply the generalized autoregressive conditional heteroskedastic mixed data sampling model for the study. Our empirical findings on various indexes and enterprises in the Shanghai and Hong Kong markets show that Chinese macroeconomic variables have a greater power to explain the volatility in Hong Kong than in Shanghai. They also contribute significantly to Hong Kong’s market volatility.
Flexible ammonia handling strategies using both cutaneous and branchial epithelia in the highly ammonia-tolerant Pacific hagfish
Authors: Clifford Alexander M. , Weinrauch Alyssa M. , Edwards Susan L. , Wilkie Michael P. , Goss Greg G.
Published: May 2017

Hagfish consume carrion, potentially exposing them to hypoxia, hypercapnia, and high environmental ammonia (HEA). We investigated branchial and cutaneous ammonia handling strategies by which Pacific hagfish ( Eptatretus stoutii) tolerate and recover from high ammonia loading. Hagfish were exposed to HEA (20 mmol/l) for 48 h to elevate plasma total ammonia (TAmm) levels before placement into divided chambers for a 4-h recovery period in ammonia-free seawater where ammonia excretion ( JAmm) was measured independently in the anterior and posterior compartments. Localized HEA exposures were also conducted by subjecting hagfish to HEA in either the anterior or posterior compartments. During recovery, HEA-exposed animals increased JAmmin both compartments, with the posterior compartment comprising ~20% of the total JAmmcompared with ~11% in non-HEA-exposed fish. Plasma TAmmincreased substantially when whole hagfish and the posterior regions were exposed to HEA. Alternatively, plasma TAmmdid not elevate after anterior localized HEA exposure. JAmmwas concentration dependent (0.05–5 mmol/l) across excised skin patches at up to eightfold greater rates than in skin sections that were excised from HEA-exposed hagfish. Skin excised from more posterior regions displayed greater JAmmthan those from more anterior regions. Immunohistochemistry with hagfish-specific anti-rhesus glycoprotein type c (α-hRhcg; ammonia transporter) antibody was characterized by staining on the basal aspect of hagfish epidermis while Western blotting demonstrated greater expression of Rhcg in more posterior skin sections. We conclude that cutaneous Rhcg proteins are involved in cutaneous ammonia excretion by Pacific hagfish and that this mechanism could be particularly important during feeding.
Thrombotic Microangiopathy Secondary to Intravenous Abuse of Opana® ER
Authors: Thakur Kamia , Agrawal Vaibhav , Kass Ashley , Dimarino Lauren M. , Dorion R. Patrick , Vadakara Joseph
Published: May 2017

Opana ER (oxymorphone) is an opioid drug available throughout the United States, and intravenous abuse of the crushed oral formulation has been associated with drug-induced thrombotic microangiopathy. In this abstract, we describe two young patients who lived together and used Opana ER intravenously. Both presented with microangiopathic hemolytic anemia that mimicked thrombotic thrombocytopenic purpura (TTP). Treating this condition poses a clinical challenge, as it is difficult to distinguish it from TTP. The role for plasma exchange is not clear but can be used while awaiting the results of the ADAMTS-13 activity, but ultimately supportive care with drug discontinuation is the recommended therapy of choice. Patients should be counseled against Opana ER’s intravenous use, and users should be offered drug rehabilitation therapy.
Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair
Authors: Chijimatsu Ryota , Ikeya Makoto , Yasui Yukihiko , Ikeda Yasutoshi , Ebina Kosuke , Moriguchi Yu , Shimomura Kazunori , Hart David A , Yoshikawa Hideki , Nakamura Norimasa
Published: May 2017

Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. Our aim was to investigate the feasibility of MSC-like cells originated from iPSCs via NCCs for osteochondral repair. Initially, MSC-like cells derived from iPSC-NCCs (iNCCs) were generated and characterized in vitro. These iNCC-derived MSC-like cells (iNCMSCs) exhibited a homogenous population and potential for osteochondral differentiation. No upregulation of pluripotent markers was detected during culture. Second, we implanted iNCMSC-derived tissue-engineered constructs into rat osteochondral defects without any preinduction for specific differentiation lineages. The implanted cells remained alive at the implanted site, whereas they failed to repair the defects, with only scarce development of osteochondral tissue in vivo. With regard to tumorigenesis, the implanted cells gradually disappeared and no malignant cells were detected throughout the 2-month follow-up. While this study did not show that iNCMSCs have efficacy for repair of osteochondral defects when implanted under undifferentiated conditions, iNCMSCs exhibited good chondrogenic potential in vitro under appropriate conditions. With further optimization, iNCMSCs may be a new source for tissue engineering of cartilage.
Retrospective Study of Vitreous Tap Technique Using Needle Aspiration for Management of Shallow Anterior Chamber during Phacoemulsification
Authors: Nossair Ashraf Ahmed , Ewais Wael Ahmed , Ali Lamia Samy
Published: May 2017

Purpose.To evaluate the technique of vitreous tap using needle aspiration for management of anterior chamber shallowness during phacoemulsification.Methods.A retrospective study included 26 eyes of 17 patients who underwent phacoemulsification in which vitreous tap was performed using a 27-gauge needle attached to a 5 ml syringe, inserted 3.5 mm from the limbus to aspirate 0.2 ml of liquefied vitreous if a cohesive (OVD) failed to sufficiently deepen the anterior chamber.Results.Preoperative anterior chamber depth was 2.31 ± 0.26 mm, axial length was 21.7 ± 0.67 mm, lens thickness was 4.5 ± .19 mm, and cataract grade was 3.77 ± 1.4. Preoperative CDVA in LogMAR units was 0.98 ± 0.75. Coexisting angle closure glaucoma was present in 7 patients (26.92%) preoperatively. Vitreous needle tap was successful in vitreous removal on the first attempt in 26 eyes (100%). Postoperative follow-up period was 22.88 ± 10.24 (4–39) months. The final postoperative CDVA in LogMAR units was 0.07 ± 0.1, while the final postoperative IOP was 16.54 ± 1.45 mmHg. No complications related to vitreous tap were noted.Conclusion.Vitreous needle tap is a simple, cost-effective, and safe technique for management of shallow anterior chamber in phacoemulsification.
Fatty Amides from Crude Rice Bran Oil as Green Corrosion Inhibitors
Authors: Reyes-Dorantes E. , Zuñiga-Díaz J. , Quinto-Hernandez A. , Porcayo-Calderon J. , Gonzalez-Rodriguez J. G. , Martinez-Gomez L.
Published: May 2017

Due to its high oil content, this research proposes the use of an agroindustrial byproduct (rice bran) as a sustainable option for the synthesis of corrosion inhibitors. From the crude rice bran oil, the synthesis of fatty amide-type corrosion inhibitors was carried out. The corrosion inhibitory capacity of the fatty amides was evaluated on an API X-70 steel using electrochemical techniques such as real-time corrosion monitoring and potentiodynamic polarization curves. As a corrosive medium, a CO2-saturated solution (3.5% NaCl) was used at three temperatures (30, 50, and 70°C) and different concentrations of inhibitor (0, 5, 10, 25, 50, and 100 ppm). The results demonstrate that the sustainable use of agroindustrial byproducts is a good alternative to the synthesis of environmentally friendly inhibitors with high corrosion inhibition efficiencies.
Bioactive Phytochemicals: Efficient Synthesis of Optically Active Substituted Flav-3-enes and Flav-3-en-3-o-R Derivatives
Authors: Achilonu Matthew Chilaka , Sedibe Moosa Mahmood , Shale Karabo
Published: May 2017

The structural core of flavene (2-phenyl-2H-chromene) is commonly found in plant flavonoids, which exhibit a wide range of biological activities and diverse pharmacological profiles (e.g., antioxidant and anticancer activities). Flavonoids have attracted significant interest in medicinal and synthetic chemistry. Substituted flav-3-ene 13 was exclusively synthesized by the stereoselective elimination of the O-mesyl moiety on C-3 of 5,7,3′,4′-tetramethoxyflavan-3-mesylate 12 with 1,8-diazabicyclo[5.4.0]undec-7-ene. The reaction of 5,7,3′,4′-tetramethoxyflavan-3-one 15 with ytterbium trifluoromethanesulfonate in methanol afforded a novel 3-O-substituted flav-3-ene derivative (3,5,7,3′,4′-pentamethoxyflav-3-ene) 17. The reduction of 4-(1,3,5-trihydroxybenzene)-5,7,3′,4′-tetra-O-benzylflavan-3-one 19b with hydrogen afforded a new compound: 3-hydroxy-4-(1,3,5-trihydroxybenzene)-5,7,3′,4′-tetrahydroxyflavan-3-en-3-ol 21 in good yield (95%), while the acetylation of 19a and 21 afforded the expected novel flav-3-en-3-acetoxy derivatives 20 (92%) and 22 (90%), respectively.
Sporadic Retroperitoneal Hemangioblastoma: Report of a Case and Review of the Literature
Authors: Jalikis F. G. , Hoch B. L. , Bakthavatsalam R. , Montenovo M. I.
Published: May 2017

We report a case of sporadic isolated hemangioblastoma arising from the retroperitoneum and provide a review of the scarce literature regarding this very rare tumor. Furthermore, we thoroughly describe the pathologic features and the broad differential diagnosis that should always be included in the study of any retroperitoneal soft tissue mass to arrive at the final diagnosis.
The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis
Authors: Alosaimi Fahad D. , AlMulhem Alaa , Moscovici Mario , AlShalan Hanan , Alqazlan Mohammad , Aldaif Abdulgader , Sockalingam Sanjeev
Published: May 2017

Introduction. Multiple sclerosis (MS) is a common disorder in some regions of the world, with over 2.3 million people diagnosed worldwide. Cognitive impairment is one of the earliest symptoms to present in the course of the disease and can cause significant morbidity. We proposed a study to explore the psychosocial predictors of cognitive impairment in MS patients in Saudi Arabia, a previously unexplored patient population. Methods. Demographic data, depression scale (PHQ9), symptom burden (PHQ15), anxiety (GAD7), disease duration, and Montreal Cognitive Assessment (MOCA) scores were collected from 195 patients in a neurology clinic in Ryiadh, Saudi Arabia. Univariate and multiple regression analyses were conducted to identify variables that are significantly associated with cognitive impairment. Results. Variables that were identified to be significantly associated with cognition, p<0.05, were education level, disease duration, and family history. Discussion. Both education level and disease duration were variables identified in previous studies. We showed family history to be a significant variable, and no association was found with depression or anxiety, which is unique to our study population. Conclusions. We identified several psychosocial predictors that are associated with cognition in our patient population. It was also noted that a difference exists between patient populations, highlighting the need for further studies in specific geographical regions.
Acutely Obstructed Airway Resulting from Complications of a Laryngopyocoele
Authors: Mole Rosalind , Hayes Stephen , Dennis Simon
Published: May 2017

Laryngocoeles are rare cystic dilatations of the laryngeal ventricle. Obstruction of its outlet can cause entrapment of mucus and superimposed infection causes a laryngopyocoele. Such presentations, although rare, have potential to cause airway obstruction. A 67-year-old lady presented with a one-week history of hoarseness and shortness of breath. On examination, she was stridulous and had fullness of the left side of the neck. Nasendoscopy revealed large bilateral vocal cord polyps and near-complete glottis obstruction. She was taken to emergency theatre for restoration of a viable airway. Upon excision of the polyps, pus was visualised originating from the laryngeal ventricle. Literature proposes that laryngocoeles develop secondary to a one-way valve caused by an obstructing lesion distorting the saccule neck. We propose that the laryngocoele developed secondary to large obstructing polyps. Urgent excision of the polyps allowed decompression of the laryngopyocoele and reestablishment of a patent airway.
NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer
Authors: Elsarraj Hanan S. , Valdez Kelli E. , Hong Yan , Grimm Sandra L. , Ricci Lawrence R. , Fan Fang , Tawfik Ossama , May Lisa , Cusick Therese , Inciardi Marc , Redick Mark , Gatewood Jason , Winblad Onalisa , Hilsenbeck Susan , Edwards Dean P. , Hagan Christy R. , Godwin Andrew K. , Fabian Carol , Behbod Fariba
Published: May 2017

The beneficial versus detrimental roles of estrogen plus progesterone (E+P) in breast cancer remains controversial. Here we report a beneficial mechanism of E+P treatment in breast cancer cells driven by transcriptional upregulation of the NFκB modulator NEMO, which in turn promotes expression of the tumor suppressor protein promyelocytic leukemia (PML). E+P treatment of patient-derived epithelial cells derived from ductal carcinoma in situ (DCIS) increased secretion of the proinflammatory cytokine IL6. Mechanistic investigations indicated that IL6 upregulation occurred as a result of transcriptional upregulation of NEMO, the gene that harbored estrogen receptor (ER) binding sites within its promoter. Accordingly, E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression, NFκB activation, and IL6 secretion. In two mouse xenograft models of DCIS, we found that RNAi-mediated silencing of NEMO increased tumor invasion and progression. This seemingly paradoxical result was linked to NEMO-mediated regulation of NFκB and IL6 secretion, increased phosphorylation of STAT3 on Ser727, and increased expression of PML, a STAT3 transcriptional target. In identifying NEMO as a pivotal transcriptional target of E+P signaling in breast cancer cells, our work offers a mechanistic explanation for the paradoxical antitumorigenic roles of E+P in breast cancer by showing how it upregulates the tumor suppressor protein PML. Cancer Res; 77(14); 3802–13. ©2017 AACR.
Mechanisms of Tolerance Induction
Authors: Nowak-Węgrzyn Anna , Chatchatee Pantipa
Published: May 2017

Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important pathway of allergic IgE sensitization in infants. In recent years, the collective evidence has pointed toward the protective effect of an early feeding with peanut and egg in children with eczema, taking advantage of the pathways underlying oral tolerance to counteract epicutaneous exposure. An addendum to the NIAID food allergy guidelines recommends introduction of peanut into the diet of 4- to 6-month-old infants with severe eczema or egg allergy as an effective strategy to prevent peanut allergy. Strategies aimed at restoring the skin barrier are currently explored as an alternative approach of prevention of eczema and allergic sensitization. Manipulation of the diet via supplementation with probiotics and prebiotics to restore the healthy gut microbiota represents another potential pathway to induction of tolerance in the gut. Oral, epicutaneous, and sublingual routes of food immunotherapy are promising and induce desensitization in the majority of the treated subjects with food allergy but are not proven to restore permanent oral tolerance. Rigorous multicenter randomized clinical trials are necessary to elucidate the optimal timing, dose, duration, as well as the preventive and therapeutic effects of these diverse approaches.
Introduction of Complementary Foods to Infants
Authors: West Christina
Published: May 2017

While earlier food allergy prevention strategies implemented avoidance of allergenic foods in infancy, the current paradigm is shifting from avoidance to controlled exposure. This review focuses on the outcome of recent randomized controlled trials, which have examined the early introduction of allergenic foods for allergy prevention, and discusses the implementation of results in clinical practice. In infants at high risk of allergic disease, there is now direct evidence that regular early peanut consumption will reduce the prevalence of peanut allergy, compared to avoidance. Many international infant feeding guidelines already recommend complementary foods, including allergenic foods, to be introduced from 4 to 6 months of age irrespective of family history risk. Interim guidelines from 10 International Pediatric Allergy Associations state that healthcare providers should recommend the introduction of peanut-containing products into the diets of infants at high risk of allergic disease in countries where peanut allergy is prevalent. Direct translation of the results obtained from a cohort of high-risk infants to the general population has proved difficult, and issues regarding feasibility, safety, and cost-effectiveness have been raised. Five randomized placebo-controlled trials have assessed the effects of early egg exposure in infancy with varying results. In a recent comprehensive meta-analysis, there was moderate-certainty evidence that early versus late introduction of egg was associated with a reduced egg allergy risk. Although promising, optimal timing, doses, and if the feeding regimen should be stratified according to infant allergy risk remain to be determined. The single study that assessed introduction of multiple foods from 3 months whilst breastfeeding compared with exclusive breastfeeding until 6 months of age showed no reduction in food allergy prevalence. Future research should aim at optimizing infant feeding regimens and support a tolerogenic gastrointestinal microenvironment during the period of food allergen introduction.
HOXB4 Increases Runx1 Expression to Promote the de novo Formation of Multipotent Hematopoietic Cells
Authors: Teichweyde Nadine , Horn Peter A. , Klump Hannes
Published: May 2017

Background: The de novo generation of patient-specific hematopoietic stem and progenitor cells from induced pluripotent stem cells (iPSCs) has become a promising approach for cell replacement therapies in the future. However, efficient differentiation protocols for producing fully functional human hematopoietic stem cells are still missing. In the mouse model, ectopic expression of the human homeotic selector protein HOXB4 has been shown to enforce the development of hematopoietic stem cells (HSCs) in differentiating pluripotent stem cell cultures. However, the mechanism how HOXB4 mediates the formation of HSCs capable of long-term, multilineage repopulation after transplantation is not well understood yet. Methods: Using a mouse embryonic stem (ES) cell-based differentiation model, we asked whether retrovirally expressed HOXB4 induces the expression of Runx1/AML1, a gene whose expression is absolutely necessary for the formation of definitive, adult HSCs during embryonic development. Results: During ES cell differentiation, basal expression of Runx1 was observed in all cultures, irrespective of ectopic HOXB4 expression. However, only in those cultures ectopically expressing HOXB4, substantial amounts of hematopoietic progenitors were generated which exclusively displayed increased Runx1 expression. Conclusions: Our results strongly suggest that HOXB4 does not induce basal Runx1 expression but, instead, mediates an increase of Runx1 expression which appears to be a prerequisite for the formation of hematopoietic stem and progenitor cells.
Novel Treatment Options in Head and Neck Cancer
Authors: Schuler Patrick J. , Laban Simon , Doescher Johannes , Bullinger Lars , Hoffmann Thomas K.
Published: May 2017

The treatment of head and neck squamous cell carcinoma (HNSCC) has been a medical challenge with limited improvement in overall survival over the past few decades. However, recently, very interesting innovations in the field of immunotherapy have been shown to be beneficial for patients with advanced HNSCC. In this article, the latest medical developments are reviewed with special focus on the clinical achievements and current clinical studies in the field of immunotherapy. The landscape of clinical studies has changed considerably from antibody-based growth factor inhibition towards immune checkpoint modulation, and new indications in the adjuvant and neoadjuvant setting are being tested in large patient cohorts. Even the combination of 2 or more immune modulatory approaches and the correct synchronization with standard cancer therapy is promising and warrants suitable clinical trials.
Esporte na Primeira República: a história do espetáculo
Authors: Jeuken Bruno
Published: May 2017

Em 2015, Wilson Gambeta publica em livro sua tese de doutorado. O historiador analisa a formação dos espetáculos esportivos na cidade de São Paulo, com destaque para palco do futebol espetáculo: o Velódromo da Consolação. Este trabalho, que preza pela simplicidade na linguagem e pela precisão conceitual, constrói uma narrativa que explica o futebol paulistano sem essencializá-lo, ou seja, sem utilizar argumentos autoreferentes. Temos nesta obra uma narrativa que destrincha as relações sociais e os processos históricos que permitiram a constitução do esporte espetáculo como conhecemos. A forma com que o autor consegue construir essa narrativa é o eixo central desta resenha.
TGF-β
1
(Transforming Growth Factor-β
1
) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity
Authors: Salvarani Nicolò , Maguy Ange , De Simone Stefano A. , Miragoli Michele , Jousset Florian , Rohr Stephan
Published: May 2017

Background—

TGF-β
1
(transforming growth factor-β
1
) importantly contributes to cardiac fibrosis by controlling differentiation, migration, and collagen secretion of cardiac myofibroblasts. It is still elusive, however, to which extent TGF-β
1
alters the electrophysiological phenotype of myofibroblasts and cardiomyocytes and whether it affects proarrhythmic myofibroblast–cardiomyocyte crosstalk observed in vitro.

Methods and Results—

Patch-clamp recordings of cultured neonatal rat ventricular myofibroblasts revealed that TGF-β
1
, applied for 24 to 48 hours at clinically relevant concentrations (≤2.5 ng/mL), causes substantial membrane depolarization concomitant with a several-fold increase of transmembrane currents. Transcriptome analysis revealed TGF-β
1
–dependent changes in 29 of 63 ion channel/pump/connexin transcripts, indicating a pleiotropic effect on the electrical phenotype of myofibroblasts. Whereas not affecting cardiomyocyte membrane potentials and cardiomyocyte–cardiomyocyte gap junctional coupling, TGF-β
1
depolarized cardiomyocytes coupled to myofibroblasts by ≈20 mV and increased gap junctional coupling between myofibroblasts and cardiomyocytes >5-fold as reflected by elevated connexin 43 and consortin transcripts. TGF-β
1
–dependent cardiomyocyte depolarization resulted from electrotonic crosstalk with myofibroblasts as demonstrated by immediate normalization of cardiomyocyte electrophysiology after targeted disruption of coupled myofibroblasts and by cessation of ectopic activity of cardiomyocytes coupled to myofibroblasts during pharmacological gap junctional uncoupling. In cardiac fibrosis models exhibiting slow conduction and ectopic activity, block of TGF-β
1
signaling completely abolished both arrhythmogenic conditions.

Conclusions—

TGF-β
1
profoundly alters the electrophysiological phenotype of cardiac myofibroblasts. Apart from possibly contributing to the control of cell function in general, the changes proved to be pivotal for proarrhythmic myofibroblast–cardiomyocyte crosstalk in vitro, which suggests that TGF-β
1
may play a potentially important role in arrhythmogenesis of the fibrotic heart.
A Forgotten Mobilization: The Tunisian Volunteer Movement for Palestine in 1948
Authors: Watanabe Shoko
Published: May 2017

This paper goes beyond the ideological views of nationalist leaders who positioned the departure of Tunisian volunteer soldiers for Palestine in 1948 in the framework of national-liberation history, and it analyzes the volunteer movement to provide a picture of the internal mechanisms of popular mobilization. This was a dual movement, of spontaneous participation and organized recruitment by local committees. The volunteers were ideologically heterogeneous, some having had no previous political career. The decentralized nature of the mobilization and the regionally differing socioeconomic compositions of the volunteers suggest that regionally diverse trajectories of nationalism movements coexisted in Tunisia. Understanding this volunteer movement from the bottom up, focusing particularly on the socioeconomic conditions that made the mobilization possible, can help us understand the dynamism of nationalism as a social movement.
John D. Cooper and His Demonstration of a Curtiss Flying Boat in Istanbul, 1914: The First American Aircraft Sold to Turkey
Authors: Leiser Gary
Published: May 2017

This article describes the career of John D. Cooper, an early American aviator and a leading test pilot for Glenn Curtiss. In the latter role he demonstrated a Curtiss flying boat in Istanbul in 1914 before a massive crowd. This aircraft was subsequently sold to Turkey and provided the primary stimulus to Ottoman naval aviation. It was also the first American aircraft sold in the Middle East.
A new species of the genus Oxyporus Fabricius (Coleoptera: Staphylinidae: Oxyporinae) in Yunnan Province, China
Authors: LI GUO-FENG , WANG CHUN-MEI , LI HUA-FENG , LI ZHI-GANG , HUANG PU-ZE
Published: May 2017

Oxyporus (Oxyporus) wangae sp. nov. is described from Yunnan, China. Color images of the habitus and aedeagus of the new species are included. A key to the genus Oxyporus of Yunnan Province species is provided.
Revision of the grassland leafhopper genus Jilinga Ghauri (Hemiptera: Cicadellidae: Deltocephalinae: Paralimnini) with description of a new species from China
Authors: ZHANG HUINING , DAI WU
Published: May 2017

The paralimnine leafhopper genus Jilinga Ghauri is revised and additional characters of the leg and female genitalia are described. A new species, Jilinga taibaiensis sp. nov., from China is described. Habitus photographs and illustrations of male and female genitalia of J. taibaiensis sp. nov. and J. asymmetrica Xing are provided. A key is given to distinguish males of five species.
A new species of Cladotanytarsus (Lenziella) from Oregon supports the systematic concept of the subgenus (Diptera: Chironomidae)
Authors: PUCHALSKI MATEUSZ , GIŁKA WOJCIECH
Published: May 2017

A new species of the genus Cladotanytarsus Kieffer, 1921 and the small subgenus Lenziella Kieffer, 1922 is described from Southern Oregon, USA. The adult male of C. (L.) glaber Giłka et Puchalski, sp. nov., featuring tibial lobes armed with dense setae and a large globular swelling of the hypopygial inferior volsella, supports the recently defined systematic concept for Lenziella. This subgenus is known from seven species distributed in the Northern Hemisphere (1 European, 1 Palaearctic and 5 Nearctic), the males of which are included in an updated identification key.
MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration
Authors: Takewaki M. , Kajiya M. , Takeda K. , Sasaki S. , Motoike S. , Komatsu N. , Matsuda S. , Ouhara K. , Mizuno N. , Fujita T. , Kurihara H.
Published: May 2017

Transplantation of mesenchymal stem cells (MSCs), which possess self-renewing properties and multipotency, into a periodontal defect is thought to be a useful option for periodontal tissue regeneration. However, developing more reliable and predictable implantation techniques is still needed. Recently, we generated clumps of an MSC/extracellular matrix (ECM) complex (C-MSC), which consisted of cells and self-produced ECM. C-MSCs can regulate their cellular functions in vitro and can be grafted into a defect site, without any artificial scaffold, to induce bone regeneration. Accordingly, this study aimed to evaluate the effect of C-MSC transplantation on periodontal tissue regeneration in beagle dogs. Seven beagle dogs were employed to generate a premolar class III furcation defect model. MSCs isolated from dog ilium were seeded at a density of 7.0 × 104 cells/well into 24-well plates and cultured in growth medium supplemented with 50 µg/mL ascorbic acid for 4 d. To obtain C-MSCs, confluent cells were scratched using a micropipette tip and were then torn off as a cellular sheet. The sheet was rolled up to make round clumps of cells. C-MSCs were maintained in growth medium or osteoinductive medium (OIM) for 5 or 10 d. The biological properties of C-MSCs were evaluated in vitro, and their periodontal tissue regenerative activity was tested by using a dog class III furcation defect model. Immunofluorescence analysis revealed that type I collagen fabricated the form of C-MSCs. OIM markedly elevated calcium deposition in C-MSCs at day 10, suggesting its osteogenic differentiation capacity. Both C-MSCs and C-MSCs cultured with OIM transplantation without an artificial scaffold into the dog furcation defect induced periodontal tissue regeneration successfully compared with no graft, whereas osteogenic-differentiated C-MSCs led to rapid alveolar bone regeneration. These findings suggested that the use of C-MSCs refined by self-produced ECM may represent a novel predictable periodontal tissue regenerative therapy.
Why are missionaries in America? A case study of a Korean mission movement in the United States
Authors: Kim Rebecca Y.
Published: May 2017

Why are missionaries coming to the United States? Why is the country that is a top missionary-sending nation also a top missionary destination? Based on an in-depth case study of one of the largest missionary-sending agencies in South Korea that sends many of its missionaries to the United States, this article explores five reasons for the phenomena of missionaries in America. These factors include the perennial importance of the Great Commission among impassioned majority-world evangelicals as well as their framing of the United States as a “great nation,” the “modern Rome,” and a dominant “Christian nation in crisis” in the late 20th century.
From Tractors to Territory: Socialist Urbanization through Standardization
Authors: Crawford Christina E.
Published: May 2017

This article proposes that the Fordist model of industrial standardization enabled and empowered the Soviets to enact distinctly socialist, decentralized, urban patterns. It follows the design of the Kharkiv Tractor Factory (KhTZ) and the socialist city ( sotsgorod) to house its workers, built outside of the first capital of Soviet Ukraine between 1930 and 1931. The near-impossible schedule of Stalin’s hyperindustrialization drive, known as the first Five-Year Plan (1928-1932), limited the options both tractor factory and sotsgorod designers could pursue, which made easily replicable architectural types and models particularly attractive. Once tested on an experimental site like KhTZ, a type deemed successful joined the ranks of those ready for slight adjustment—a process known as priviazka in Soviet architectural discourse—and export to far-flung sites in the Soviet sphere.
Establishing Specific Links Between Parenting Styles and the S-Anxieties in Children: Separation, Social, and School
Authors: Yaffe Yosi
Published: May 2017

This study investigates the relationship between parenting styles and three specific types of anxiety among children, with an attempt to monitor the distinctive role that each parental dimension plays with regard to elevated anxiety. Study participants included 101 children, ages 11 to 13 years, from various elementary schools. The study found that lack of autonomy granting by either parent is uniquely related (controlled for parent’s acceptance) to high anxiety levels and specific anxiety types in children, especially separation anxiety and school anxiety. With respect to parental acceptance, a unique negative correlation with children’s overall anxiety was found only for the father, while the mother’s low acceptance was negatively correlated with social anxiety for highly anxious children. Ultimately, it was found that children who perceived their parents as authoritarian (highly controlling and strict disciplinarians) were significantly more anxious than the children who perceived their parents as authoritative (encouraging independence while maintaining limits and behavioral control).
Implication of foam sclerosant inactivation by human whole blood in a laboratory setting
Authors: Dabbs Emma B , Dos Santos Scott J , Mainsiouw Laurensius E , Sheikh Alina A , Gkantiragas Alexis , Shiangoli Irenie , Watkins Mike R , Nemchand Jaya L , Whiteley Mark S
Published: May 2017

Background

During sclerotherapy, it has been recommended to confirm intravenous placement of the needle by aspirating blood into the sclerosant syringe. This may inactivate some, or all of the sclerosant.

Aims

To quantify the volume of human blood needed to completely inactivate 1 ml of sodium tetradecyl sulphate, and comparing fresh blood and blood that has been stored in an ethylenediaminetetraacetic acid tube.

Methods

A series of manual titrations were carried out following a procedure developed at STD Pharmaceutical Products Ltd (Hereford, UK) and listed in the British Pharmacopeia. Three percent of sodium tetradecyl sulphate stock solutions were made with increasing volumes of blood and titrated against benzethonium chloride to determine the active concentration (% w/v) of sodium tetradecyl sulphate remaining in the solution.

Results

A calculated approximation showed 0.3 ml of blood is required to fully inactivate 1 ml of 3% sodium tetradecyl sulphate when made into a foam. A comparison was made between the use of fresh blood and blood stored in ethylenediaminetetraacetic acid tubes. Blood stored in ethylenediaminetetraacetic acid tubes showed more inactivation of sodium tetradecyl sulphate, but this was not significant at the P ≤ 0.05 level.

Conclusion

The data from our study have shown that a minimum of 0.3 ml of fresh blood is required to inactivate 1 ml of 3% sodium tetradecyl sulphate as a foam and it is not significantly affected by storing blood in an ethylenediaminetetraacetic acid tube. Our methodology suggests that during foam sclerotherapy treatment, blood should not be aspirated into the syringe to confirm position, and that ultrasound guidance is more appropriate for needle placement.
The Angel of Geography
Authors: Katz Cindi
Published: May 2017

Contemporary capitalism is in the throes of crises precipitated by over-accumulation and the effects of decades of privatization, commodification, and financialization, each sieved through the other. The angel of geography is conjured to mark these crises on the grounds of everyday life. Their profound and uneven consequences for the present and future, seen in the shifting discourses and material social practices around children and childhood, call for redress. This piece builds upon my ongoing project, ‘childhood as spectacle’, to examine what is at stake in the accomplishment of social reproduction – and its failures – in turbulent times and heterogeneous spaces. Looking closely at the ways aspirations for the future are defined, managed, reached, and deferred in and through the family and schools, I take stock of contemporary social reproduction and its anxieties. Drawing on three popular and contradictory cultural productions, the films Race to Nowhere and Waiting for Superman, and the best-selling book Battle Hymn of the Tiger Mother by Amy Chua, I will address some of the ways the lives and wellbeing of some children – middle-class and wealthier children – have been fetishized while others – the vast majority of children – suffer the consequences of a disinvested public sphere and a radically reduced social wage. As the sense of precariousness stemming from the financial crises of the past decade widens and infiltrates everyday life more deeply, this situation becomes more acute. In this context, aspiration and its management can be framed as a cultural politics ripe for unpacking; a structure of feeling whose drives and effects may illuminate the present as a political moment.
Theory and Method in Public Administration
Authors: Pandey Sanjay K.
Published: May 2017

Despite widespread agreement about goals of knowledge development in public administration, there is imbalance in efforts directed at these goals. The overlap between the domains of theory and practice is not substantial. Important concerns in public administration theory and practice are outweighed by naïve quantitative bias (NQB), an unfortunate methodological artifact. This symposium seeks to highlight this imbalance and to nudge the public administration scholarly community toward paying attention to theoretical and practical matters, recognizing NQB and mitigating its undesirable effects on knowledge development. Broadly speaking, two recommendations emerge from symposium contributions. The first recommendation emphasizes paying attention to theoretical goals. The second recommendation is to promote reflexivity about how the domains of theory and method interact to counter the methodological artifact of NQB. A brief overview of each article in the symposium and its contribution to advancing knowledge development is provided.
Jihadi brides and female volunteers: Reading the Islamic State’s war to see gender and agency in conflict dynamics
Authors: Sjoberg Laura
Published: May 2017

Decades ago, Cynthia Enloe called for a research agenda looking for where women are in war and conflict. Enloe recognized that women play active roles in and are affected by wars and conflicts, but are often ignored in news coverage, policy analysis, and scholarship. The current conflict in Syria and Iraq appears as a counterexample: hundreds of millions of Google results mention women and the Islamic State (IS). Subjects vary widely: the stories cover female victims of IS, female recruits to IS, and women who fight IS. This article explores the hypervisibility of women in this conflict, looking for lessons about sex, gender, and conflict. The first part analyses discourses in a sample of major news reports, evaluating how different women around IS are represented. It finds that agency is removed from both female victims and female IS partisans, while it is exaggerated for women who fight against IS. This corresponds with emphasis on different gendered traits for differently positioned women. After tracing these gendered representations, the article applies theories of gender and conflict to understand how women have become central to the fighting and coverage of the conflict in Syria and Iraq. It concludes that paying attention both to the empirical presence of women and to the co-constitution of gender, war, and conflict augments understanding of this war, and across conflicts.
Staff, associate specialist and specialty doctors’ national audit on the management of gonorrhoea in the United Kingdom, 2015
Authors: Mullan Helen , Richards Jane , Lee John
Published: May 2017

The British Association for Sexual Health and HIV (BASHH) revised United Kingdom national guideline for the management of gonorrhoea in adults, 2011, identified five auditable outcome measures, namely, that all patients should receive first-line treatment, be screened or treated for chlamydial infection, have a test of cure (TOC), be offered written information and have partner notification carried out. The UK National Guideline for Gonorrhoea Testing, Clinical Effectiveness Group, BASHH, 2012, recommended in addition that all reactive nucleic acid amplification tests (NAATs) from pharynx and rectum should be confirmed by supplementary testing, using a second NAAT which detects a different nucleic acid target, all those with a positive NAAT for gonorrhoea should have culture and antimicrobial susceptibility testing and that TOC should be done by two weeks. Staff, associate specialist and specialty doctors performed a national audit against these standards. Data from 3233 cases were submitted; 8% of cases of gonorrhoea diagnosed in England, Scotland and Wales over this period. We found that 83% patients received first-line treatment with a reason for not doing so provided for 11%. TOC was documented for 62% and written information was offered to 41%. Results about supplementary testing were inconsistent. The results for the other outcomes were satisfactory.
Cruel to Be Kind: Factors Underlying Altruistic Efforts to Worsen Another Person’s Mood
Authors: López-Pérez Belén , Howells Laura , Gummerum Michaela
Published: May 2017

When aiming to improve another person’s long-term well-being, people may choose to induce a negative emotion in that person in the short term. We labeled this form of agent-target interpersonal emotion regulation altruistic affect worsening and hypothesized that it may happen when three conditions are met: (a) The agent experiences empathic concern for the target of the affect-worsening process, (b) the negative emotion to be induced helps the target achieve a goal (e.g., anger for confrontation or fear for avoidance), and (c) there is no benefit for the agent. This hypothesis was tested by manipulating perspective-taking instructions and the goal to be achieved while participants ( N = 140) played a computer-based video game. Participants following other-oriented perspective-taking instructions, compared with those following objective perspective-taking instructions, decided to induce more anger in a supposed fellow participant who was working to achieve a confrontation goal and to induce more fear in a supposed fellow participant who was working to achieve an avoidance goal.
A hypothesis: King Henry VIII’s (1491–1547) personality change: A case of lead poisoning?
Authors: Charlton Anne
Published: May 2017

Henry VIII (1491–1547) became King of England in 1509. He started out as a good monarch, sensible, reasonable and pleasant, but later his behaviour changed drastically. He became irascible, intolerant, violent and tyrannical. In January 1536, Henry had a serious jousting accident and was unconscious for 2 h. It is generally believed that this accident played a major role in his personality change. Letters of that time, however, indicate that the change began insidiously in 1534 and became most drastic in 1535, a year before the accident. Henry had suffered from leg ulcers before and after the accident and had been constantly treated for them for many years. Sloane MS1047, now in the British Library in London, contains the prescriptions for the medications used to treat these ulcers. Many of the medications contain a high proportion of lead in various forms. Lead can be absorbed through skin, especially damaged skin. Absorbed lead can affect the brain, causing psychiatric problems, especially those associated with violence. The author presents a hypothesis that absorbed lead from his medications might have been a major factor in King Henry’s personality change.
Re-establishing the ‘outsiders’: English press coverage of the 2015 FIFA Women’s World Cup
Authors: Black Jack , Fielding-Lloyd Beth
Published: May 2017

In 2015, the England Women’s national football team finished third at the Women’s World Cup in Canada. Alongside the establishment of the Women’s Super League in 2011, the success of the women’s team posed a striking contrast to the recent failures of the England men’s team and in doing so presented a timely opportunity to examine the negotiation of hegemonic discourses on gender, sport and football. Drawing upon an ‘established-outsider’ approach, this article examines how, in newspaper coverage of the England women’s team, gendered constructions revealed processes of alteration, assimilation and resistance. Rather than suggesting that ‘established’ discourses assume a normative connection between masculinity and football, the findings reveal how gendered ‘boundaries’ were both challenged and protected in newspaper coverage. Despite their success, the discursive positioning of the women’s team as ‘outsiders’, served to (re)establish men’s football as superior, culturally salient and ‘better’ than the women’s team/game. Accordingly, we contend that attempts to build and, in many instances, rediscover the history of women’s football can be used to challenge established cultural representations that draw exclusively from the history of the men’s game. In such instances, the 2015 Women’s World Cup provides a historical moment from which the women’s game can be relocated in a context of popular culture.
Development of multifunctional carbon composite bipolar plate for vanadium redox flow batteries
Authors: Lee Dongyoung , Lee Dai Gil , Lim Jun Woo
Published: May 2017

The carbon/epoxy composite bipolar plate is a promising substitute for the conventional graphite bipolar plate for the vanadium redox flow battery due to its high mechanical property and productivity. The carbon/epoxy composite bipolar plate, a multifunctional structure, requires expanded graphite coating or additional surface treatments to decrease the interfacial contact resistance. However, expanded graphite coating has low durability under vanadium redox flow battery operating condition and surface treatments are costly to implement. In this work, excess resin-absorbing method is developed with polyester fabric to uniformly remove the resin-rich layer and expose carbon fibers on the surface of the carbon/epoxy composite bipolar plate. This method not only decreases the interfacial contact resistance by exposing carbon fibers but also forms a unique ditch pattern which is desirable to fix carbon felt electrode in place. Durability against acidic environment, mechanical property, and gas permeability of the composite bipolar plate manufactured by excess resin-absorbing method is investigated.