bluuebunny/crossref_metadata_2025 huggingface dataset:
Photocatalytic activity of magnetic core-shell CoFe2O4@ZnO nanoparticles for purification of methylene blue
Authors: Suharyadi Edi , Muzakki Afifah , Nofrianti Astrie , Istiqomah Nurul Imani , Kato Takeshi , Iwata Satoshi
Published: August 2020

Magnetic core–shell CoFe2O4@ZnO nanoparticles have been successfully synthesized by using coprecipitation method to provide easy separated nanomaterials and high photocatalytic activity performance. Core–shell nanoparticles with various CoFe2O4-to-ZnO molar ratio (1:2, 1:3, 1:4, 1:5) have been investigated over x-ray diffraction (XRD), transmission electron microscopy (TEM), UV-visible spectroscopy, and vibrating sample magnetometer. XRD spectra confirm the cubic spinel ferrite phase structure of CoFe2O4 and the hexagonal wurtzite phase of ZnO. The crystallite size is found within the range of 14.9–20.6 nm. TEM measurement confirms the good crystallinity of the samples. The magnetic hysteresis shows that CoFe2O4@ZnO has high saturation magnetization of about 30 emu g−1 and coercivity of about 300 Oe. Photocatalytic investigation was carried out using methylene blue (MB) under UV irradiation. Our result yields the enhancement of MB degradation as ZnO content increases. The maximum photodegradation achieved by the core–shell nanoparticles is 57.2%, 60.5%, 65.5%, and 78.3% for molar ratio of 1:2, 1:3, 1:4, and 1:5, respectively. The enhancement of MB degradation can be attributed to the formation of internal structure between CoFe2O4 and ZnO in the form of heterojunction structure. The magnetic properties of core–shell lead to the easy separation between the magnetic core–shell nanoparticles and the final degraded solution by permanent magnet.
Adiabatic preparation of entangled, magnetically ordered states with cold bosons in optical lattices
Authors: Venegas-Gomez Araceli , Schachenmayer Johannes , Buyskikh Anton S , Ketterle Wolfgang , Chiofalo Maria Luisa , Daley Andrew J
Published: August 2020

We analyze a scheme for preparation of magnetically ordered states of two-component bosonic atoms in optical lattices. We compute the dynamics during adiabatic and optimized time-dependent ramps to produce ground states of effective spin Hamiltonians, and determine the robustness to decoherence for realistic experimental system sizes and timescales. Ramping parameters near a phase transition point in both effective spin-1/2 and spin-1 models produces entangled spin-symmetric states that have potential future applications in quantum enhanced measurement. The preparation of these states and their robustness to decoherence is quantified by computing the quantum Fisher information (QFI) of final states. We identify that the generation of useful entanglement should in general be more robust to heating than it would be implied by the state fidelity, with corresponding implications for practical applications.
River capture or ancestral polymorphism: an empirical genetic test in a freshwater fish using approximate Bayesian computation
Authors: Souza Mateus S , Thomaz Andréa T , Fagundes Nelson J R
Published: August 2020

A headwater or river capture is a phenomenon commonly invoked to explain the absence of reciprocal monophyly of genetic lineages among isolated hydrographic basins in freshwater fish. Under the assumption of river capture, a secondary contact between populations previously isolated in different basins explains the observed genetic pattern. However, the absence of reciprocal monophyly could also arise under population isolation through the retention of ancestral of polymorphisms. Here, we applied an approximate Bayesian computation (ABC) framework for estimating the relative probability of scenarios with and without secondary contact. We used Cnesterodon decemmaculatus as a study model because of the multiple possible cases of river capture and the demographic parameters estimated in a previous mitochondrial DNA study that are useful for simulating scenarios to test both hypotheses using the ABC framework. Our results showed that, in general, mitochondrial DNA is useful for distinguishing between these alternative demographic scenarios with reasonable confidence, but in extreme cases (e.g. recent divergence or large population size) there is no power to discriminate between scenarios. Testing hypotheses of drainage rearrangement under a statistically rigorous framework is fundamental for understanding the evolution of freshwater fish fauna as a complement to, or in the absence of, geological evidence.
Connecting to motor recovery after stroke
Authors: Fowler Jill H , Kalaria Raj N
Published: August 2020

This scientific commentary refers to ‘Structural brain networks and functional motor outcome after stroke –a prospective cohort study’, by Schlemm et al. (https://doi.org/10.1093/braincomms/fcaa001) in Brain Communications and ‘Brain responsivity provides an individual readout for motor recovery after stroke’ by Tscherpel et al. (https://doi.org/10.1093/brain/awaa127) in Brain
Assessing keloid recurrence following surgical excision and radiation
Authors: Gold Michael H , Nestor Mark S , Berman Brian , Goldberg David
Published: August 2020

Keloids are a fibroproliferative disorder that can result from a cutaneous injury to the reticular dermis. Recurrence rates as high as 100% have been reported following surgical excision alone. Consequently, a variety of post-surgical techniques have been employed to prevent keloid recurrence, including the use of radiation. Although numerous studies have shown post-excisional X-rays, electron beam, lasers and brachytherapy can reduce the rate of keloid recurrence, numerous inconsistencies, including a wide range of definitions for keloid recurrence, make it difficult to compare study outcomes. The review aims to examine the various means for defining keloid recurrence in clinical trials involving the use of radiation therapy.

Searches of the Cochrane Library and PubMed were performed to identify the available information for post-surgical keloid recurrence following radiation therapy. Each identified study was reviewed for patient follow-up and criteria used to define keloid recurrence. The search results included clinical studies with external beam radiation, brachytherapy and superficial radiation therapy. Many studies did not include a definition of keloid recurrence, or defined recurrence only as the return of scar tissue. Other studies defined keloid recurrence based on patient self-assessment questionnaires, symptoms and scar elevation and changes in Kyoto Scar Scale, Japan Scar Workshop Scale and Vancouver Scar Scale scores.

The results of this review indicate keloidectomy followed by radiation therapy provide satisfactory recurrence rates; however, clinical studies evaluating these treatments do not describe treatment outcomes or use different definitions of keloid recurrence. Consequently, recurrence rates vary widely, making comparisons across studies difficult. Keloid recurrence should be clearly defined using both objective and subjective measures.
Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
Authors: Sharma Priyanka , Shimura Tadanobu , Banwait Jasjit K , Goel Ajay
Published: August 2020

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality in the USA. As much as 50–60% of CRC patients develop resistance to 5-fluorouracil (5FU)-based chemotherapeutic regimens, attributing the increased overall morbidity and mortality. In view of the growing evidence that active principles in various naturally occurring botanicals can facilitate chemosensitization in cancer cells, herein, we undertook a comprehensive effort in interrogating the activity of one such botanical—andrographis—by analyzing its activity in CRC cell lines [both sensitive and 5FU resistant (5FUR)], a xenograft animal model and patient-derived tumor organoids. We observed that combined treatment with andrographis was synergistic and resulted in a significant and dose-dependent increase in the efficacy of 5FU in HCT116 and SW480 5FUR cells (P < 0.05), reduced clonogenic formation (P < 0.01) and increased rates of caspase-9-mediated apoptosis (P < 0.05). The genomewide expression analysis in cell lines led us to uncover that activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways were the key mediators for the anti-cancer and chemosensitizing effects of andrographis. Subsequently, we validated our findings in a xenograft animal model, as well as two independent CRC patient-derived organoids—which confirmed that combined treatment with andrographis was significantly more effective than 5FU and andrographis alone and that these effects were in part orchestrated through dysregulated expression of key genes (including HMOX1, GCLC, GCLM and TCF7L2) within the ferroptosis and Wnt-signaling pathways. Collectively, our data highlight that andrographis might offer a safe and inexpensive adjunctive therapeutic option in the management of CRC patients.
Contextual Fear Memory Retrieval Is Vulnerable to Hippocampal Noise
Authors: Iwasaki Satoshi , Ikegaya Yuji
Published: August 2020

Memory retrieval depends on reactivation of memory engram cells. Inadvertent activation of these cells is expected to cause memory-retrieval failure, but little is known about how noisy activity of memory-irrelevant neurons impacts mnemonic processes. Here, we report that optogenetic nonselective activation of only tens of hippocampal CA1 cells (∼0.01% of the total cells in the CA1 pyramidal cell layer) impairs contextual fear memory recall. Memory recall failure was associated with altered neuronal reactivation in the basolateral amygdala. These results indicate that hippocampal memory retrieval requires strictly regulated activation of a specific neuron ensemble and is easily disrupted by the introduction of noisy CA1 activity, suggesting that reactivating memory engram cells as well as silencing memory-irrelevant neurons are both crucial for memory retrieval.
Dynamic Adjustments of Midfrontal Control Signals in Adults and Adolescents
Authors: Gyurkovics Mate , Levita Liat
Published: August 2020

During task performance, our level of cognitive control is dynamically adjusted to task demands as reflected, for example, by the congruency sequence effect (CSE) in conflict tasks. Although brain areas related to cognitive control show protracted maturation across adolescence, previous studies found that adolescents show similar behavioral CSEs to adults. In the present study, we investigated whether there are age-related changes in the neural underpinnings of dynamic control adjustments using electroencephalography. Early adolescents (ages 12–14, N = 30) and young adults (ages 25–27, N = 29) completed a confound-minimized flanker task optimized for the detection of sequential control adjustments. The CSE was observed in midfrontal theta power thought to capture anterior cingulate cortex-mediated monitoring processes but was not modulated significantly by age. Adolescents, however, showed a smaller congruency effect in the power and cross-trial temporal consistency of midfrontal theta oscillations than adults. No age differences were observed in phase-based connectivity between midfrontal and lateral frontal regions in the theta band. These findings provide strong support for the role of midfrontal theta oscillations in conflict monitoring and reactive control and suggest that the cognitive system of early adolescents initially responds less reliably to the occurrence of conflict than that of adults.
Using Whole-genome Sequencing to Determine the Timing of Secondary Tuberculosis in British Columbia, Canada
Authors: Romanowski Kamila , Sobkowiak Benjamin , Guthrie Jennifer L , Cook Victoria J , Gardy Jennifer L , Johnston James C
Published: August 2020

Combined with epidemiological data, whole-genome sequencing (WGS) can help better resolve individual tuberculosis (TB) transmission events to a degree not possible with traditional genotyping. We combine WGS data with patient-level data to calculate the timing of secondary TB among contacts of people diagnosed with active TB in British Columbia, Canada.
Evaluating the Efficacy of Therapies in Patients With Coronavirus Disease 2019
Authors: Lin Dan-Yu , Zeng Donglin , Eron Joseph J
Published: August 2020

There is a proliferation of clinical trials worldwide to find effective therapies for patients diagnosed with coronavirus disease 2019 (COVID-19). The endpoints that are currently used to evaluate the efficacy of therapeutic agents against COVID-19 are focused on clinical status at a particular day or on time to a specific change of clinical status. To provide a full picture of the clinical course of a patient and make complete use of available data, we consider the trajectory of clinical status over the entire follow-up period. We also show how to combine the evidence of treatment effects on the occurrences of various clinical events. We compare the proposed and existing endpoints through extensive simulation studies. Finally, we provide guidelines on establishing the benefits of treatments.
Mutations in an Aquaglyceroporin as a Proven Marker of Antimony Clinical Resistance in the Parasite Leishmania donovani
Authors: Potvin Jade-Eva , Leprohon Philippe , Queffeulou Marine , Sundar Shyam , Ouellette Marc
Published: August 2020

Background

Antimonial drugs have long been the mainstay to treat visceral leishmaniasis. Their use has been discontinued in the Indian subcontinent because of drug resistance, but they are still clinically useful elsewhere. The goal of this study was to find markers of antimony resistance in Leishmania donovani clinical isolates and validate experimentally their role in resistance.

Methods

The genomes of sensitive and antimony-resistant clinical isolates were sequenced. The role of a specific gene in contributing to resistance was studied by CRISPR-Cas9–mediated gene editing and intracellular drug sensitivity assays.

Results

Both gene copy number variations and single nucleotide variants were associated with antimony resistance. A homozygous insertion of 2 nucleotides was found in the gene coding for the aquaglyceroporin AQP1 in both resistant isolates. Restoring the wild-type AQP1 open reading frame re-sensitized the 2 independent resistant isolates to antimonials. Alternatively, editing the genome of a sensitive isolate by incorporating the 2-nucleotide insertion in its AQP1 gene led to antimony-resistant parasites.

Conclusions

Through genomic analysis and CRISPR-Cas9–mediated genome editing we have proven the role of the AQP1 mutations in antimony clinical resistance in L. donovani.
Corruption and the Public Service Ethos in Mid-Victorian Administration: The Case of Leonard Horner and the Factory Office
Authors: Cawood Ian
Published: August 2020

While the problem of political corruption in mid-nineteenth century Britain has been much studied, the experience of corrupt behaviour in public bodies, both new and long established, is comparatively neglected. This article takes the example of one of the first inspectorates set up after the Great Reform Act, the Factory Office, to examine the extent of corrupt practices in the British civic state and the means whereby it was addressed. It examines the changing processes of appointment, discipline and promotion, the issues of remuneration and venality, and the relationships between inspectors, workers, factory owners, the government and the wider civil service, and the press and public opinion. The article argues that the changing attitudes of the inspectors, especially those of Leonard Horner, were indicative of a developing ‘public service ethos’ in both bureaucratic and cultural settings and that the work of such unsung administrators was one of the agencies through which corrupt behaviour in the civic structures of Victorian Britain was, with public support, challenged. The article concludes that the endogenous reform of bureaucratic practice achieved by the factory inspectorate may even be of equal significance as that which resulted from the celebrated Northcote–Trevelyan Report of 1854.
Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia
Authors: Gaudet Daniel , Karwatowska-Prokopczuk Ewa , Baum Seth J , Hurh Eunju , Kingsbury Joyce , Bartlett Victoria J , Figueroa Amparo L , Piscitelli Philip , Singleton Walter , Witztum Joseph L , Geary Richard S , Tsimikas Sotirios , O'Dea Louis St. L ,   the Vupanorsen Study Investigators
Published: August 2020

Aims 

Loss-of-function mutations in ANGPTL3 are associated with beneficial effects on lipid and glucose metabolism and reduced risk of coronary artery disease. Vupanorsen (AKCEA-ANGPTL3-L Rx ) is an N-acetyl galactosamine-conjugated antisense oligonucleotide targeted to the liver that selectively inhibits angiopoietin-like 3 (ANGPTL3) protein synthesis.

Methods and results 

This was a double-blind, placebo-controlled, dose-ranging, Phase 2 study. Patients (N =105) with fasting triglycerides >150 mg/dL (>1.7 mmol/L), type 2 diabetes, and hepatic steatosis were treated for 6 months with 40 or 80 mg every 4 weeks (Q4W), or 20 mg every week (QW) of vupanorsen, or placebo given subcutaneously. The primary efficacy endpoint was per cent change in fasting triglycerides from baseline at 6 months. Median baseline triglycerides were 2.84 mmol/L (252 mg/dL). Significant reductions in triglycerides of 36%, 53%, 47%, and in ANGPTL3 of 41%, 59%, 56%, were observed in the 40 mg Q4W, 80 mg Q4W, and 20 mg QW groups, respectively, compared with 16% reduction in triglycerides and 8% increase in ANGPTL3 in placebo. Compared with placebo, vupanorsen 80 mg Q4W reduced apolipoprotein C-III (58%), remnant cholesterol (38%), total cholesterol (19%), non-high-density lipoprotein cholesterol (HDL-C; 18%), HDL-C (24%), and apolipoprotein B (9%). There was no improvement in glycaemic parameters, or hepatic fat fraction. Treatment with vupanorsen was not associated with clinically significant changes in platelet counts, and the most common adverse events were those at the injection site, which were generally mild.

Conclusion 

Vupanorsen results in a favourable lipid/lipoprotein profile and provides a potential strategy for residual cardiovascular risk reduction.
Efficacy and safety of left atrial appendage electrical isolation during catheter ablation of atrial fibrillation: an updated meta-analysis
Authors: Romero Jorge , Gabr Mohamed , Patel Kavisha , Briceno David , Diaz Juan Carlos , Alviz Isabella , Trivedi Chintan , Mohanty Sanghamitra , Polanco Dalvert , Della Rocca Domenico Giovanni , Lakkireddy Dhanunjaya , Natale Andrea , Di Biase Luigi
Published: August 2020

Aims

Left atrial appendage electrical isolation (LAAEI) has been shown to improve freedom from all-atrial arrhythmia recurrence in patients with non-paroxysmal atrial fibrillation (AF). The aim of this study is to investigate the long-term efficacy and safety outcomes of LAAEI in patients with non-paroxysmal AF undergoing catheter ablation.

Methods and results

A systematic review of Medline, Cochrane, and Embase was performed for clinical studies evaluating the benefit of LAAEI in non-paroxysmal AF. Nine studies with a total of 2336 patients were included (mean age: 65 ± 9 years, 63% male). All studies included patients with persistent AF, long-standing persistent AF, or both. At a mean follow-up of 40.5 months, patients who underwent LAAEI had significantly higher freedom from all-atrial arrhythmia recurrence than patients who underwent standard ablation alone [69.3% vs. 46.4%; risk ratio (RR) 0.54; 95% confidence interval (CI) 0.42–0.69; P < 0.0001]. A 46% relative risk reduction and 22.9% absolute risk reduction in atrial-arrhythmia recurrence was noted with LAAEI. Rates of cerebral thromboembolism were not significantly different between the two groups (LAAEI 3% vs. standard ablation 1.6%, respectively; RR 1.76; 95% CI 0.61–5.04; P = 0.29). Furthermore, there was no significant difference in the acute procedural complication rates between the two groups (LAAEI 4% vs. standard ablation 3%, respectively; RR 1.29; 95% CI 0.83–2.02; P = 0.26).

Conclusion

At long-term follow-up, LAAEI led to a significantly higher improvement in freedom from all-atrial arrhythmia recurrence in patients with non-paroxysmal AF, when compared to standard ablation alone. Importantly, this benefit was achieved without an increased risk of acute procedural complications or cerebral thromboembolic events.
The influence of fault reactivation on injection-induced dynamic triggering of permeability evolution
Authors: Yildirim Elif Cihan , Im Kyungjae , Elsworth Derek
Published: August 2020

Mechanisms controlling fracture permeability enhancement during injection-induced and natural dynamic stressing remain unresolved. We explore pressure-driven permeability (k) evolution by step-increasing fluid pressure (p) on near-critically stressed laboratory fractures in shale and schist as representative of faults in sedimentary reservoirs/seals and basement rocks. Fluid is pulsed through the fracture with successively incremented pressure to first examine sub-reactivation permeability response that then progresses through fracture reactivation. Transient pore pressure pulses result in a permeability increase that persists even after the return of spiked pore pressure to the null background level. We show that fracture sealing is systematically reversible with the perturbing pressure pulses and pressure-driven permeability enhancement is eminently reproducible even absent shear slip and in the very short term (order of minutes). These characteristics of the observed fracture sealing following a pressure perturbation appear similar to those of the response by rate-and-state frictional healing upon stress/velocity perturbations. Dynamic permeability increase scales with the pore pressure magnitude and fracture sealing controls the following per-pulse permeability increase, both in the absence and presence of reactivation. However, initiation of the injection-induced reactivation results in a significant increase in the rate of permeability enhancement (dk/dp). These results demonstrate the role of frictional healing and sealing of fractures at interplay with other probable processes in pore pressure-driven permeability stimulation, such as particle mobilization.
Introducing Ecohealth education in a Teacher Training Institute in Lao PDR: a case study
Authors: Tomokawa Sachi , Asakura Takashi , Keosada Ngouay , Bouasangthong Vannasouk , Souvanhxay Vanthala , Navamal Phetnoy , Kanyasan Kethsana , Miyake Kimihiro , Kokudo Shohei , Watanabe Ryuichi , Soukhavong Sithane , Thalangsy Khamseng , Moji Kazuhiko
Published: August 2020

This paper argues the effectiveness of Ecohealth education for improving the quality of health and environmental education and for achieving sustainable development in developing countries. To illustrate the need for Ecohealth education, we review the transitions in health education, environmental education and Education for Sustainable Development (ESD) in various developing countries. Moreover, we discuss issues relating to these disciplines and consider the possible roles that Ecohealth education can play. Then, drawing on a case study conducted in Lao PDR, we propose a concrete example of the teaching content of Ecohealth education. We conclude that Ecohealth education can embody the concepts of ESD with respect to health and environmental issues, and thus can contribute to improvements in the quality of health and environmental education, and of ESD. In addition, we propose the following five actions for implementing Ecohealth education in developing countries: (i) promote research based on the approaches of public health and anthropology, and develop teaching materials that use the research results, (ii) empower school-aged children, (iii) encourage the active involvement and sharing of problems among communities, (iv) strengthen participatory teaching and learning methodology and (v) build a training system and train relevant teachers.
The Imperial War Graves Commission, the war dead and the burial of a royal body, 1914–32.
Authors: Connelly Mark , Goebel Stefan
Published: August 2020

The mass deaths of British and imperial soldiers during the First World War created a crisis of commemoration. How could the bereaved come to terms with the losses when their deceased loved ones were buried so far from home, or had disappeared completely? Attempting to impose a common solution, the Imperial War Graves Commission (founded in 1917) committed itself to non-repatriation of bodies and standard treatment of war graves. In doing so, it ran the risk of contradicting the wishes of bereaved families. This article explores how the grave of Prince Maurice of Battenberg became a test case for the Commission in its quest for legitimacy and the aptness of its approach against the opposition of Maurice’s mother, Princess Beatrice, daughter of Queen Victoria. It reveals the I.W.G.C.’s desire to avoid public controversy while sticking to its guiding principles, and its belief that far from being exempt from those principles through her royal status, Princess Beatrice had a moral obligation to accept and embrace them.
Excess mortality during the COVID-19 outbreak in Italy: a two-stage interrupted time-series analysis
Authors: Scortichini Matteo , Schneider dos Santos Rochelle , De’ Donato Francesca , De Sario Manuela , Michelozzi Paola , Davoli Marina , Masselot Pierre , Sera Francesco , Gasparrini Antonio
Published: August 2020

Background

Italy was the first country outside China to experience the impact of the COVID-19 pandemic, which resulted in a significant health burden. This study presents an analysis of the excess mortality across the 107 Italian provinces, stratified by sex, age group and period of the outbreak.

Methods

The analysis was performed using a two-stage interrupted time-series design using daily mortality data for the period January 2015–May 2020. In the first stage, we performed province-level quasi-Poisson regression models, with smooth functions to define a baseline risk while accounting for trends and weather conditions and to flexibly estimate the variation in excess risk during the outbreak. Estimates were pooled in the second stage using a mixed-effects multivariate meta-analysis.

Results

In the period 15 February–15 May 2020, we estimated an excess of 47 490 [95% empirical confidence intervals (eCIs): 43 984 to 50 362] deaths in Italy, corresponding to an increase of 29.5% (95% eCI: 26.8 to 31.9%) from the expected mortality. The analysis indicates a strong geographical pattern, with the majority of excess deaths occurring in northern regions, where few provinces experienced increases up to 800% during the peak in late March. There were differences by sex, age and area both in the overall impact and in its temporal distribution.

Conclusion

This study offers a detailed picture of excess mortality during the first months of the COVID-19 pandemic in Italy. The strong geographical and temporal patterns can be related to the implementation of lockdown policies and multiple direct and indirect pathways in mortality risk.
Reflection on modern methods: building causal evidence within high-dimensional molecular epidemiological studies of moderate size
Authors: Ponsonby Anne-Louise
Published: August 2020

This commentary provides a practical perspective on epidemiological analysis within a single high-dimensional study of moderate size to consider a causal question. In this setting, non-causal confounding is important. This occurs when a factor is a determinant of outcome and the underlying association between exposure and the factor is non-causal. That is, the association arises due to chance, confounding or other bias rather than reflecting that exposure and the factor are causally related. In particular, the influence of technical processing factors must be accounted for by pre-processing measures to remove artefact or to control for these factors such as batch run. Work steps include the evaluation of alternative non-causal explanations for observed exposure-disease associations and strategies to obtain the highest level of causal inference possible within the study. A systematic approach is required to work through a question set and obtain insights on not only the exposure-disease association but also the multifactorial causal structure of the underlying data where possible. The appropriate inclusion of molecular findings will enhance the quest to better understand multifactorial disease causation in modern observational epidemiological studies.
Effects of evaporation parameters on recuperative transcritical organic Rankine cycle using binary mixture fluids
Authors: Hsieh Jui-Ching , Cheng Chu-Hong
Published: August 2020

In this study, thermodynamic analysis was performed on basic and recuperative transcritical organic Rankine cycles by using five pure and six mixed fluids. The effects of evaporation parameters on the first- and second-law efficiencies (ηI and ηII) as well as power output were investigated. The results indicate that a recuperator had a positive effect on the ηI and ηII and negative effects on the specific power. The total irreversibility of the system was improved by the recuperator. However, the total irreversibility considerably increased with an increase in the expander inlet temperature (Texp,in) due to the significant increase in irreversibility in the condenser, particularly for working fluids with low critical temperatures, namely R134a, R1234yf and R290, and low proportions of R245fa and R600a in mixed fluids. For both the pure and mixed fluids, the specific power linearly increased with an increase in the expander inlet pressure (Pexp,in) and Texp,in. However, with an increase in Pexp,in, the ηI and ηII first increased and then decreased. Finally, for ηI and ηII, the effect of the recuperator increased with an increase in Texp,in even though the recuperator had a relatively small effect on the working fluids with high critical temperature, especially when Pexp,in was high.
Error estimates for fully discrete BDF finite element approximations of the Allen–Cahn equation
Authors: Akrivis Georgios , Li Buyang
Published: August 2020

For a class of compatible profiles of initial data describing bulk phase regions separated by transition zones, we approximate the Cauchy problem of the Allen–Cahn (AC) phase field equation by an initial-boundary value problem in a bounded domain with the Dirichlet boundary condition. The initial-boundary value problem is discretized in time by the backward difference formulae (BDF) of order $1\leqslant q\leqslant 5$ and in space by the Galerkin finite element method of polynomial degree $r-1$, with $r\geqslant 2$. We establish an error estimate of $O(\tau ^q\varepsilon ^{-q-\frac 12}+h^{r}\varepsilon ^{-r-\frac 12}+{e}^{-c/\varepsilon })$ with explicit dependence on the small parameter $\varepsilon$ describing the thickness of the phase transition layer. The analysis utilizes the maximum-norm stability of BDF and finite element methods with respect to the boundary data, the discrete maximal $L^p$-regularity of BDF methods for parabolic equations and the Nevanlinna–Odeh multiplier technique combined with a time-dependent inner product motivated by a spectrum estimate of the linearized AC operator.
Strongly Peaking Representations and Compressions of Operator Systems
Authors: Davidson Kenneth R , Passer Benjamin
Published: August 2020

We use Arveson’s notion of strongly peaking representation to generalize uniqueness theorems for free spectrahedra and matrix convex sets that admit minimal presentations. A fully compressed separable operator system necessarily generates the $C^*$-envelope and is such that the identity is the direct sum of strongly peaking representations. In particular, a fully compressed presentation of a separable operator system is unique up to unitary equivalence. Under various additional assumptions, minimality conditions are sufficient to determine a separable operator system uniquely.
Temporal and Microspatial Heterogeneity in Transmission Dynamics of Coendemic Plasmodium vivax and Plasmodium falciparum in Two Rural Cohort Populations in the Peruvian Amazon
Authors: Rosas-Aguirre Angel , Guzman-Guzman Mitchel , Chuquiyauri Raul , Moreno Marta , Manrique Paulo , Ramirez Roberson , Carrasco-Escobar Gabriel , Rodriguez Hugo , Speybroeck Niko , Conn Jan E , Gamboa Dionicia , Vinetz Joseph M , Llanos-Cuentas Alejandro
Published: August 2020

Background

Malaria is highly heterogeneous: its changing malaria microepidemiology needs to be addressed to support malaria elimination efforts at the regional level.

Methods

A 3-year, population-based cohort study in 2 settings in the Peruvian Amazon (Lupuna, Cahuide) followed participants by passive and active case detection from January 2013 to December 2015. Incidence and prevalence rates were estimated using microscopy and polymerase chain reaction (PCR).

Results

Lupuna registered 1828 infections (1708 Plasmodium vivax, 120 Plasmodium falciparum; incidence was 80.7 infections/100 person-years (95% confidence interval [CI] , 77.1–84.5). Cahuide detected 1046 infections (1024 P vivax, 20 P falciparum, 2 mixed); incidence was 40.2 infections/100 person-years (95% CI, 37.9–42.7). Recurrent P vivax infections predominated onwards from 2013. According to PCR data, submicroscopic predominated over microscopic infections, especially in periods of low transmission. The integration of parasitological, entomological, and environmental observations evidenced an intense and seasonal transmission resilient to standard control measures in Lupuna and a persistent residual transmission after severe outbreaks were intensively handled in Cahuide.

Conclusions

In 2 exemplars of complex local malaria transmission, standard control strategies failed to eliminate submicroscopic and hypnozoite reservoirs, enabling persistent transmission.
Cyanoacrylate Nail Glue and the Pajama Catalyst
Authors: Rich Harvey , Cubitt Jonathan J
Published: August 2020

Nail glues are routinely used for the application of false nails and are readily available for unrestricted purchase from highstreet and online retailers. We present the case of a young lady who accidentally spilled her nail glue on to her cotton pajama trouser leg setting off a violent exothermic reaction that resulted in a full-thickness burn injury to her foot. She ultimately went on to require surgical debridement and skin grafting. We intend to remind both healthcare workers and members of the public that while nail glue alone in contact with the skin is relatively harmless, contact together with natural fibers such as cotton clothing produces a dangerous chemical reaction, which is too often underestimated and can lead to serious burn injuries. Our patient and the surgical team agree that more must be done to raise awareness of the risks these products pose, and retailers must ensure consumers are responsibly informed.
The Behavioral Effects of (Unenforceable) Contracts†
Authors: Starr Evan , Prescott J J , Bishara Norman
Published: August 2020

Do contracts influence behavior independent of the law governing their enforceability? We explore this question in the context of employment noncompetes using nationally representative data for 11,500 labor force participants. We show that noncompetes are associated with reductions in employee mobility and changes in the direction of that mobility (i.e., toward noncompetitors) in both states that do and do not enforce noncompetes. Decomposing mobility into job offer generation and acceptance, we detect no evidence of differences in job search, recruitment, or offer activity associated with noncompetes. Rather, we find that employees with noncompetes—even in states that do not enforce them—frequently point to their noncompete as an important reason for declining offers from competitors. Our data further show that these employees’ beliefs about the likelihood of a lawsuit or legal enforcement are important predictors of their citing a noncompete as a factor in their decision to decline competitor offers.
Phlebotominae (Diptera: Psychodidae) and Biomes in the State of Mato Grosso do Sul, Brazil
Authors: Barrios Suellem Petilim Gomes , Pereira Luciana Escalante , Casaril Aline Etelvina , Infran Jucelei de Oliveira Moura , Fernandes Wagner de Souza , Oshiro Elisa Teruyia , Galati Eunice Aparecida Bianchi , Graciolli Gustavo , Paranhos Filho Antônio Conceição , de Oliveira Alessandra Gutierrez
Published: August 2020

The state of Mato Grosso do Sul, Brazil is an important region of South America regarding leishmaniasis, with the great diversity of sandflies reported since 1938 and wide biodiversity represented by its biomes (Atlantic Forest, Cerrado, and Pantanal). A checklist of sandflies is presented here for the state and respective biomes. The data base was compiled from primary and secondary data. The primary data collection involved automatic light traps at Miranda–Abobral Pantanal subregion and in subregion Baixa Nhecolância of Pantanal. The secondary data were obtained from entomology scientific collections and a literature review of articles from 1938 to 2019, including entomological museum collections. A total of 71 species were reported, belonging to 14 genera and 13 subgenera, in 61 municipalities of the state, including the type locality of 9 species, and the first report of Lutzomyia cruzi (Mangabeira 1938), vector of Leishmania infantum (Nicolle 1937), in the Pantanal region of Miranda–Abobral. Other vector species, Bichromomyia flaviscutellata (Mangabeira 1942), Lutzomyia longipalpis (Lutz & Neiva 1912), Nyssomyia antunesi (Coutinho 1939), Nyssomyia intermedia (Lutz & Neiva 1912), Nyssomyia neivai (Pinto 1926), and Nyssomyia whitmani (Antunes & Coutinho 1939), are reported in the entire area of the state. Maps containing the distribution of sandflies on Mato Grosso do Sul biomes were produced. The eclecticism of the species in relation to their ecotypes was observed, with several species using the three biome types as habitats and breeding sites.
Parental Experiences of Adolescent Cancer-Related Fatigue: A Qualitative Study
Authors: Loades Maria E , James Venessa , Baker Laura , Jordan Abbie , Sharma Aditi
Published: August 2020

Objective

Cancer-related fatigue is common, disabling, and chronic, but professional help is not necessarily sought. Parents can support symptom management and facilitate help-seeking. This study explored parental experiences of their adolescent’s cancer-related fatigue and what they do to help.

Methods

Qualitative semi-structured interviews were conducted with 21 parents of 17 adolescents aged 12–18 who were previously diagnosed with cancer. Reflexive thematic analysis was used to analyze the data.

Results

Three high-order themes were generated. Firstly, “fatigue is inevitable and unpredictable.” This encompassed parental perceptions of fatigue as variable, distinct from normal tiredness, and linked to sleep and mood. Fatigue was seen as arising from cancer, which rendered parents helpless. Secondly, “fatigue is disruptive to normal life” beyond cancer treatment, which is contrary to expectations. Thirdly, parents managed fatigue by trying to balance the adolescent’s desires for normality and their own perception of what is realistic with encouraging activities, and by seeking support from others.

Conclusions

Parents see adolescent cancer-related fatigue as multi-faceted and experience it as unpredictable and attributed to cancer. They struggle to distinguish normal adolescent behavior from problematic fatigue, and to balance supporting and empowering the adolescent to live life to the fullest whilst also being realistic about the limitations imposed by fatigue and the benefits of activity. Parents try to manage fatigue practically but want more information about adolescent cancer-related fatigue to help establish their own and their adolescent’s expectations.
Cadmium inhibits cell cycle progression and specifically accumulates in the maize leaf meristem
Authors: Bertels Jonas , Huybrechts Michiel , Hendrix Sophie , Bervoets Lieven , Cuypers Ann , Beemster Gerrit T S
Published: August 2020

It is well known that cadmium (Cd) pollution inhibits plant growth, but how this metal impacts leaf growth processes at the cellular and molecular level is still largely unknown. In the current study, we show that Cd specifically accumulates in the meristematic tissue of the growing maize leaf, while Cd concentration in the elongation zone rapidly declines as the deposition rates diminish and cell volumes increase due to cell expansion. A kinematic analysis shows that, at the cellular level, a lower number of meristematic cells together with a significantly longer cell cycle duration explain the inhibition of leaf growth by Cd. Flow cytometry analysis suggests an inhibition of the G1/S transition, resulting in a lower proportion of cells in the S phase and reduced endoreduplication in expanding cells under Cd stress. Lower cell cycle activity is also reflected by lower expression levels of key cell cycle genes (putative wee1, cyclin-B2-4, and minichromosome maintenance4). Cell elongation rates are also inhibited by Cd, which is possibly linked to the inhibited endoreduplication. Taken together, our results complement studies on Cd-induced growth inhibition in roots and link inhibited cell cycle progression to Cd deposition in the leaf meristem.
Haplotype-based genome-wide association increases the predictability of leaf rust (Puccinia triticina) resistance in wheat
Authors: Liu Fang , Jiang Yong , Zhao Yusheng , Schulthess Albert W , Reif Jochen C
Published: August 2020

Resistance breeding is crucial for sustainable control of wheat leaf rust and single nucleotide polymorphism (SNP)-based genome-wide association studies (GWAS) are widely used to dissect leaf rust resistance. Unfortunately, GWAS based on SNPs often explained only a small proportion of the genetic variation. We compared SNP-based GWAS with a method based on functional haplotypes (FH) considering epistasis in a comprehensive hybrid wheat mapping population composed of 133 parents plus their 1574 hybrids and characterized with 626 245 high-quality SNPs. In total, 2408 and 1 139 828 significant associations were detected in the mapping population by using SNP-based and FH-based GWAS, respectively. These associations mapped to 25 and 69 candidate regions, correspondingly. SNP-based GWAS highlighted two already-known resistance genes, Lr22a and Lr34-B, while FH-based GWAS detected associations not only on these genes but also on two additional genes, Lr10 and Lr1. As revealed by a second hybrid wheat population for independent validation, the use of detected associations from SNP-based and FH-based GWAS reached predictabilities of 11.72% and 22.86%, respectively. Therefore, FH-based GWAS is not only more powerful for detecting associations, but also improves the accuracy of marker-assisted selection compared with the SNP-based approach.
The Completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: Large-scale structure catalogues for cosmological analysis
Authors: Ross Ashley J , Bautista Julian , Tojeiro Rita , Alam Shadab , Bailey Stephen , Burtin Etienne , Comparat Johan , Dawson Kyle S , de Mattia Arnaud , du Mas des Bourboux Hélion , Gil-Marín Héctor , Hou Jiamin , Kong Hui , Lyke Brad W , Mohammad Faizan G , Moustakas John , Mueller Eva-Maria , Myers Adam D , Percival Will J , Raichoor Anand , Rezaie Mehdi , Seo Hee-Jong , Smith Alex , Tinker Jeremy L , Zarrouk Pauline , Zhao Cheng , Zhao Gong-Bo , Bizyaev Dmitry , Brinkmann Jonathan , Brownstein Joel R , Rosell Aurelio Carnero , Chabanier Solène , Choi Peter D , Chuang Chia-Hsun , Cruz-Gonzalez Irene , de la Macorra Axel , de la Torre Sylvain , Escoffier Stephanie , Fromenteau Sebastien , Higley Alexandra , Jullo Eric , Kneib Jean-Paul , McLane Jacob N , Muñoz-Gutiérrez Andrea , Neveux Richard , Newman Jeffrey A , Nitschelm Christian , Palanque-Delabrouille Nathalie , Paviot Romain , Pullen Anthony R , Rossi Graziano , Ruhlmann-Kleider Vanina , Schneider Donald P , Magaña Mariana Vargas , Vivek M , Zhang Yucheng
Published: August 2020

We present large-scale structure catalogues from the completed extended Baryon Oscillation Spectroscopic Survey (eBOSS). Derived from Sloan Digital Sky Survey (SDSS) IV Data Release 16 (DR16), these catalogues provide the data samples, corrected for observational systematics, and random positions sampling the survey selection function. Combined, they allow large-scale clustering measurements suitable for testing cosmological models. We describe the methods used to create these catalogues for the eBOSS DR16 Luminous Red Galaxy (LRG) and Quasar samples. The quasar catalogue contains 343 708 redshifts with 0.8 < z < 2.2 over 4808 deg2. We combine 174 816 eBOSS LRG redshifts over 4242 deg2 in the redshift interval 0.6 < z < 1.0 with SDSS-III BOSS LRGs in the same redshift range to produce a combined sample of 377 458 galaxy redshifts distributed over 9493 deg2. Improved algorithms for estimating redshifts allow that 98 per cent of LRG observations result in a successful redshift, with less than one per cent catastrophic failures (Δz > 1000 km s−1). For quasars, these rates are 95 and 2 per cent (with Δz > 3000 km s−1). We apply corrections for trends between the number densities of our samples and the properties of the imaging and spectroscopic data. For example, the quasar catalogue obtains a χ2/DoF = 776/10 for a null test against imaging depth before corrections and a χ2/DoF= 6/8 after. The catalogues, combined with careful consideration of the details of their construction found here-in, allow companion papers to present cosmological results with negligible impact from observational systematic uncertainties.
Seeing above the clouds with high-resolution spectroscopy
Authors: Gandhi Siddharth , Brogi Matteo , Webb Rebecca K
Published: August 2020

In the last decade, ground-based high-resolution Doppler spectroscopy (HRS) has detected numerous species in transiting and non-transiting hot Jupiters, and is ideally placed for atmospheric characterization of warm Neptunes and super Earths. Many of these cooler and smaller exoplanets have shown cloudy atmospheres from low-resolution near-infrared observations, making constraints on chemical species difficult. We investigate how HRS can improve on these given its sensitivity to spectral line cores which probe higher altitudes above the clouds. We model transmission spectra for the warm Neptune GJ 3470b and determine the detectability of H2O with the CARMENES, GIANO, and SPIRou spectrographs. We also model a grid of spectra for another warm Neptune, GJ 436b, over a range of cloud-top pressure and H2O abundance. We show H2O is detectable for both planets with modest observational time and that the high H2O abundance-high cloud deck degeneracy is broken with HRS. However, meaningful constraints on abundance and cloud-top pressure are only possible in the high-metallicity scenario. We also show that detections of CH4 and NH3 are possible from cloudy models of GJ 436b. Lastly, we show how the presence of the Earth’s transmission spectrum hinders the detection of H2O for the most cloudy scenarios given that telluric absorption overlaps with the strongest H2O features. The constraints possible with HRS on the molecular species can be used for compositional analysis and to study the chemical diversity of such planets in the future.