bluuebunny/crossref_metadata_2025 huggingface dataset:
Indigenous evaluation
Authors: Stefanski Cassie , Abonyi Dr. Sylvia , Katz Dr. Richard , Nicholls Dr. Ruth , Kewistep Gilbert , Goodridge Dr. Donna , Groot Dr. Gary
Published: November 2024

Background: Indigenous evaluation incorporates Indigenous ways of knowing and draws upon cultural paradigms (Indigenous Evaluation Toolkit, 2022). Indigenous evaluation literature is limited in both quantity and quality outcomes resulting in a lack of clarity. This scoping review was conducted to identify guiding principles, Indigenous evaluation methodologies, and explore key concepts and gaps within the literature. Methods: This scoping review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) checklist and Arskey and O’Malley’s Scoping Review Framework. It included peer-reviewed articles and grey literature. Articles were identified through electronic database searching and reference lists using keywords. This review only included data written in English, available in full text, included keywords and identified the author and title of the publication. Articles that were not specific to Indigenous peoples or outlined Indigenous methodologies that were not related to evaluation were excluded. Results: Out of 348 articles, 94 met the inclusion criteria for this review. The literature revealed 13 guiding principles (collaboration, respect, relationships, self-determination, flexibility, trust, truth, reciprocity, power, time, sovereignty, responsibility/accountability, and relevance) and 15 Indigenous evaluation methodologies (culturally responsive, community-based, participatory, storytelling, empowerment, decolonizing, strength-based, self-reflection/location, mixed methods, talking circles, tribal critical theory, two-eyed seeing, the 4 R’s, trauma-informed approach, and ethical space). Conclusion: Key findings in this review demonstrate the need for further development of a culturally responsive Indigenous evaluation approach and for future research to outline how to put Indigenous evaluation methodologies and guiding principles into practice. Filling this gap will make a significant contribution to the field of evaluation research for Indigenous peoples, communities, and evaluators.
Use of Child Restraint Systems in Thailand and Factors associated with it: A Cross-Sectional Study
Authors: Vuttipittayamongkol Pakawadi , Muenpa Roungtiva , Wannapaschaiyong Prakasit
Published: November 2024

Objective: To determine the use of child restraint systems among caregivers of children in Thailand and to identify factors associated with it.
Materials and Methods: Caregivers of children under 12 years old who utilized medical services at Lampang Hospital between March 2023 and March 2024 were asked to participate in this cross-sectional study. Data on characteristics of child and caregiver, driving behavior, and knowledge about child restraint systems were collected via a questionnaire. Multivariable regression was applied to analyze associated factors.
Results: Of the 322 eligible caregivers, 279 (86.6%) participated, of which 127(44.5%) used a child restraint system. A higher caregiver education level (odds ratio [OR] 2.28, 95% CI 1.18; 4.39), and driving 3–7 days per week (OR 3.92, 95% CI 1.82; 8.40) were associated with more frequent restraint use. A higher age of the child (OR 0.97, 95% CI 0.96; 0.98) was associated with less frequent restraint use.
Conclusion: Fewer than half of the caregivers utilized child restraint systems. Higher caregiver education levels and more frequent driving were associated with more frequent use, while older child age was associated with less frequent use of child restraint systems. Targeted interventions are needed to improve the use of child restraint systems.
Correlation of American Urological Association Symptom Index Domains with Uroflowmetric Peak Flow in Thai Patients with Suspected Benign Prostatic Hyperplasia
Authors: Chayochaichana Sidaporn , Opanurak Julin , Santingamkun Apirak , Ratchanon Supoj
Published: November 2024

Objective: This study aimed to investigate the correlations between the obstructive and irritative domain scores of the total AUA-SI and the uroflowmetric peak flow rate (Qmax) in Thai patients suspected of having benign prostatic hyperplasia (BPH).
Materials and Methods: A retrospective observational study was conducted on 510 patients who presented with lower urinary tract symptoms (LUTSs) and were suspected of having BPH at the Urology Outpatient Department of King Chulalongkorn Memorial Hospital, Thailand. A self-administered AUA-SI score was used to determine the severity of symptoms, and uroflowmetry was conducted to determine parameters, including flow rate variable.
Results: A significant correlation was observed between the AUA-SI score and uroflowmetric peak flow (Qmax). The AUA-SI and its obstructive domain had weak negative Pearson correlations with uroflowmetric peak flow (r = −0.164 and −0.185, respectively; P < 0.01). The irritative domain was inversely associated with Qmax (r = 0.097, P = 0.028). However, when patients in each subgroup with mild (AUA-SI = 0 - 7), moderate (AUA-SI = 8–19), and severe symptoms (AUA-SI = 20–35) were considered, the relationship was found to be not significant.
Conclusion: The study revealed a significant weak negative correlation between the AUA-SI score and Qmax, but no significant correlations were found between the obstructive and irritative domains and Qmax in the subgroup analysis.
Improvement in the Youthfulness of Facial Skin after a Single Treatment with Platelet Rich Plasma
Authors: Akaranuchat Nutthawut , Kongkunnavat Natthapong
Published: November 2024

Objective: Platelet rich plasma (PRP) is an autologous substance widely used to stimulate dermal collagen synthesis. This study aimed to investigate the efficacy of a single PRP treatment for facial rejuvenation.
Materials and Methods: This study was conducted at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand from August 2020 to March 2021. Enrolled patients underwent a single intradermal injection treatment of 0.1 mL PRP at 30 locations on the face. Outcomes were assessed at 1, 2, and 4 weeks post-intervention using the patient-perceived age visual analog scale (VAS), FACE-Q assessment, and elasticity index (EI) with a Cutometer.
Results: Forty Thai patients with an average age of 36.4 years, Fitzpatrick skin type 3-4 were enrolled. The mean Patient-perceived Age VAS significantly decreased one month after treatment (-2.71±2.42, p<0.001). FACE-Q satisfaction with facial skin was 74.29±14.49, and satisfaction with the outcome was 73.41±16.26 (scale 0-100). The PRP significantly affected skin EI, with the peak improvement observed at 1-2 weeks post-injection, predominantly at the cheek, crow’s feet, and perioral area (all p<0.05). All patients had an overall improvement in satisfaction scores throughout the study.
Conclusion: A single treatment of PRP injection resulted in overall satisfaction in facial skin rejuvenation as measured by patient-perceived age VAS and FACE-Q assessment. The PRP showed positive outcomes in EI with peak performance at 1-2 weeks post-treatment.
Venäjän kieli pääkaupunkiseudun linja-autonkuljettajien keskuudessa
Authors: Teittinen Salla-Maija , Viimaranta Johanna
Published: November 2024

Tässä artikkelissa tarkastelemme venäjän kielen käyttöä lingua francana eli eri kielten puhujien yhteisenä kommunikaation kielenä pääkaupunkiseudun linja-autonkuljettajien keskuudessa. Tutkimusta varten on haastateltu kymmentä pääkaupunkiseudun liikennöitsijöiden palveluksessa olevaa kuljettajaa ja kolmea muuta kuljetusalan ammattilaista. Kuljettajien haastatteluissa on kartoitettu sitä, miten ja keiden kesken venäjän kieltä käytetään venäjäntaitoisten linja-autonkuljettajien jokapäiväisessä työssä. Kuljettajilta on myös kysytty heidän suhtautumisestaan venäjän käyttöön. Tutkimusaineistosta on lisäksi tarkasteltu lingua franca -käytöille tyypillisiä monikielisiä käytänteitä kuten suomen sanojen esiintymistä venäjänkielisessä puheessa. Tutkimuksen tulosten mukaan linja-autonkuljettajat suhtautuivat keväällä 2023 venäjän käyttöön hyvin käytännönläheisesti ja käyttivät sitä työssä työkavereiden ja matkustajien kanssa. Kuljettajat olivat kuitenkin tietoisia kielen muuttuneesta ja muuttuvasta asemasta.
 
This article examines the use of the Russian language as a lingua franca – a common language of interaction among speakers of different languages – within the community of bus drivers in the Finnish metropolitan area. Ten bus drivers employed by metropolitan area transport operators and three other transportation professionals were interviewed for the research. The interviews with the drivers explored how and among whom Russian is used in the daily work of bus drivers proficient in Russian. The drivers were also asked about their attitudes towards the use of Russian. The research material also looked at multilingual practices typical of lingua franca usage, such as the occurrence of Finnish words in Russian speech. According to the results of the study, in spring 2023 the drivers had a very pragmatic attitude towards the use of Russian and they tended to use the language with colleagues and passengers. Nevertheless, the drivers were aware of its changing and evolving status.
Maahanmuuttajien representaatioita Venäjän itsenäisten taiteilijoiden musiikkivideoissa: autenttisuuden rakentamisen kolme strategiaa
Authors: Simon Mark E.
Published: November 2024

Tämä artikkeli erittelee taiteellisia keinoja, joiden avulla venäläiset riippumattomat pop-artistit konstruoivat musiikkivideoissaan Venäjälle saapuneiden maahanmuuttajien hahmoja. Työperäinen maahanmuutto on vielä suhteellisen marginaalinen aihe Venäjän taiteissa ja myös populaarikulttuurissa. Artikkeli analysoi kolmea musiikkivideota, joissa tämä teema on poikkeuksellisesti keskeinen: Shortparis-yhtyeen ”Pelottaa” (”Strašno” 2018), Manižan ”Vajaasti slaavilainen nainen” (”Nedoslavjanka” 2019) ja Fardin ”IVY” (”SNG” 2020). Vaikka nämä videot eivät edusta mainstream-taidetta, niiden analyysi avaa ensinnäkin maahanmuuttajien representaation ainutlaatuisuutta verrattuna Venäjällä vakiintuneisiin mediamalleihin. Toiseksi näiden kolmen musiikkivideon keskinäinen vertailu antaa mahdollisuuden havaita itsemäärittelyn erilaisia strategioita maahanmuuton aihetta hyödyntävillä artisteilla. Artikkeli lähtee liikkeelle Diane Railtonin ja Paul Watsonin rakentamasta musiikkivideotypologiasta määrittäen kunkin analysoidun musiikkivideon genren. Se tarkastelee myös miten kussakin videossa muusikot rakentavat autenttisuuttaan kuvaamiensa maahanmuuttajahahmojen kautta.
 
This article examines different artistic means used to construct images of immigrants in music videos by Russian independent pop artists. The topic of labour migration remains relatively marginal in Russian art and popular culture. The article analyses three music videos in which this topic is discussed: “Scary” (“Strashno”) by Shortparis (2018), “Insufficiently Slavic Woman” (“Nedoslavianka”) by Manizha (2019), and Fardi’s “CIS” (“SNG”) (2020). The works are not part of the mainstream, but their analysis is nevertheless important, firstly, because it allows us to recognise their originality in the representation of migrants compared to established media patterns. Secondly, comparing these videos reveals different strategies of self-positioning employed by the artists who have turned their attention to labour migration. Drawing on the conceptual framework proposed by Diane Railton and Paul Watson, this article identifies the genre of the analysed music videos and further demonstrates how, within each video, the artists construct their own authenticity through their engagement with immigrant imagery.
Offensive Performance Indicators: A Comparative Study of Winning, Drawing, and Losing Teams in the 2023 Malaysia Super League
Authors: Nazarudin Mohamad Nizam , Septian Regi Dwi , Kosni Norlaila Azura , Maliki Ahmad Bisyri Husin Musawi
Published: November 2024

This study aimed to identify significant differences in offensive performance metrics among winning, drawing, and losing teams in the 2023 Malaysia Super League (MSL) season. Data were collected from 91 matches during the MSL football league using the InStat® system. The analysed variables included set pieces, corners, free kicks, penalties, and shooting. The results showed that winning teams had discriminative offensive performance indicators such as set pieces with shots (4.48±2.17), % set pieces with shots (17.10±8.58), corners (5.90±3.16), corners with shots (2.05±1.63), % corners with shots (36.56±27.49), free kicks with shots (0.76±0.89), % free kicks with shots (22.02±27.49), penalties (0.30±0.58), penalties converted (0.26±0.52), % penalties converted (21.11±40.35), shots (16.53±6.08), shots on target (6.97±3.35), % shots on target (42.18±13.58), shots from outside the penalty area (7.16±3.41), shots from outside the penalty area on target (2.20±1.65), and % shots from outside the penalty area on target (30.68±21.07). In contrast, drawing teams had higher mean values in set pieces (28.67±5.87) and free kicks (4.34±2.21). In conclusion, these findings have practical implications for coaches in planning and implementing offensive tactics for successful performance. Future research could explore the impact of different tactical approaches and formations on match outcomes and analyse the effectiveness of in-match tactical adjustments.
Photodynamic therapy in the treatment of periodontal diseases. Literature review
Authors: Dolgalev A. A. , Garazha S. N. , Taymazova D. T. , Choniashvili M. Z.
Published: November 2024

Periodontal diseases affect about 90% of the adult population, but the treatment regimens for this pathology are different, with varying degrees of effectiveness. One of the causes of inflammatory phenomena is the microbial factor. In some cases, there is a need for antimicrobial prescriptions, which, against the background of growing antibiotic resistance, becomes a problem. This article describes the possibilities of using such a method of influencing periodontal pathogens as photodynamic therapy. The main conclusions of studies on the effectiveness of PDT in inflammatory periodontal diseases are presented.
The necessity and demand of machine learning in treatment and diagnostics in dentistry
Authors: Margaryan E. G. , Kurenkova Yu. S. , Lalayan K. V. , Abdelrahim M. T. , Kadzhoian A. G. , Selifanova E. I. , Budaichieva Z. S. , Stepanov M. A. , Bledzhyants G. A. , Makeeva M. K.
Published: November 2024

Aim: to justify the necessity of machine learning technology in treatment and diagnostics in dentistry.

Material and methods: the research was taken using the method of anonymous questionnaire to estimate the demand and necessity of machine learning technology in diagnostics and treatment in dentistry on the basis of the E.V Borovsky Institute of Dentistry I.M Sechenov First Moscow State Medical University (Sechenov University). 100 participants from different dental specialities aged 20 to 54 took part in the questionnaire. Wilson score interval and Student’s T Critical Values were used for the statistical analysis of the

Results.

Results: during the study, it was found that the majority of dentists who participated in the questionnaire (54%) have challenges in diagnosing oral mucosal diseases. Herewith dentists with work experience more than 5 years diagnose this kind of disease more frequently than specialists with less work experience (p<0.05). Surgical dentists (46,6%) and prosthetic specialists (50%) diagnose this pathology most often. Clinicians attribute diagnostic challenges to the lack of experience (85%) and low occurrence of patients with this group of diseases. During treatment and diagnostics 84% of residents mentioned that they compare their patients’ clinical cases with clinical cases from the Internet and other resources, 78% of residents believe that machine learning will help to increase the efficiency of diagnosing oral mucosal diseases in clinical work. During the held research, it was found that 85% of participating dentists would definitely use digital programs with machine learning in their clinical work for treatment and diagnostics.

Conclusions: the presence of problems in treatment and diagnostics of oral mucosal diseases was confirmed, and to solve it, the demand and the need to develop and implement digital systems based on artificial intelligence using machine learning technology were substantiated.
Evaluation of the effectiveness of treatment of gingivitis in children according to gingival cytology
Authors: Brusnitsyna E. V. , Ioschenko E. S. , Zakirov T. V. , Voroshilina E. S. , Polushina L G. , Savchenko E. S. , Ginkel D. A.
Published: November 2024

The effectiveness of the use of PRESIDENT ADHESIUM gum balm in adolescents with chronic gingivitis was studied according to clinical and cytological data.

Materials and methods. A open non-comparative study of the effectiveness of treatment of chronic generalized catarrhal gingivitis (ICD-10 code K05.1) with PRESIDENT ADHESIUM gum balm was conducted. Thirty-eight children participated in the study, the average age was 14,9 years. Clinical dental examination included determination of caries intensity according to DMF, hygiene index OHI-S, gingival inflammation index PMA (modified by Parma), gingival sulcus bleeding index PBI (Saxer, Miihiemann). Cytologic examination of gingival fluid smears included cell evaluation, presence of atypical cell complexes, cytogenetic index counting, proliferation index, apoptosis index (according to Bazarny V.V. et al. (2019) and relative leukocyte count. Organoleptic properties of the balsam were determined on a 5-point scale.

Results. After applying PRESIDENT ADHESIUM gum balm for a week, an improvement in hygiene, a decrease in gingival inflammation and bleeding according to the PMA index by 33.54%, and bleeding according to the PBI index by 44.23%. In the gingival cytograms, the apoptosis index decreased after the treatment from 10.96±0.50 to 9.54±0.49%. The number of leukocytes decreased from 32.60±1.72 to 24.85±1.30%. Organoleptic properties of the gel were evaluated on a five-point scale at 4.46±0.43 points.

Conclusions. Cytology of gingival cells allows an objective assessment of inflammatory changes in catarrhal gingivitis in adolescents. The number of leukocytes and changes in the apoptosis index of epithelial cells can serve as criteria for diagnosis and treatment effectiveness. PRESIDENT ADHESIUM gum balm has anti-inflammatory action and good organoleptic properties and can be recommended for prevention of catarrhal gingivitis in adolescents.
Determining of the relationship between gum phenotype and anthropometric data of the face and gender
Authors: Proskokova S. V. , Vostrikov V. O. , Nikolskaya I. A. , Proskokov N. A. , Guseva O. Yu. , Kutuzov D. N. , Enikeev A. M. , Kuliev R. M.
Published: November 2024

Relevance. Diagnosis of the condition of periodontal tissues at the stage of comprehensive treatment planning for a dental patient is an important step in the work of dentists. The presence of difficulties in diagnosing the phenotypic condition of the gums dictates the need to search for additional clinical diagnostic methods that allow determining the phenotype with minimal time and financial costs.

Objective. To determine the relationship between anthropometric values of the face (width and height of the face) and gender with the gin-

gival phenotype.

Materials and methods. During the clinical examinations, an analysis was carried out of the anthropometric data of men and women obtained as a result of photometry, the results of a study of the gingival phenotype by transgingival probing using the De Rouck method and CBCT data (cone beam computed tomography) in patients with their further distribution into groups. A total of 45 people took part in the study, of which 12 were men and 33 were women.

Results. Statistical processing of the obtained data showed that for men, the differences between the groups with different phenotypes (thick/ thin) are reliable for the parameter face width. For women with different gum phenotypes (thick and thin), reliable differences were obtained between the groups for the parameters face height and face width. The gum phenotype correlates with the face width (noticeable correlation for all, high for men and women separately); face height (moderate correlation for all, men and women); but does not correlate with the facial index and gender.

Conclusion. Thus, the study showed that a combined diagnostic examination of the patient, taking into account gender, facial height and width in women, and facial width in men, can help in the correct assessment of the gingival phenotype.
Identification of prognostic factors for the development of sialadenitis on the background of radioiodine therapy
Authors: Razumova A. Ya. , Kutukova S. I. , Yaremenko A. I. , Borodavina E. V. , Petrov N. L
Published: November 2024

Introduction. Radioiodine therapy is a modern method of treating thyroid pathology. Its use is possible both in malignant tumors and in thyrotoxicosis. However, this technique has a complication in the form of impaired salivary gland function, which causes dryness in the oral cavity, its increase and pain syndrome.

The aim of our study to identify risk factors for the development of functional disorders of the salivary glands in patients who underwent radioiodine therapy.

Material and methods. A retro-prospective open-label, two-center, non-randomized study was conducted, which included 61 patients who received radiotherapy for thyroid diseases. In 33/61 patients, there were no signs of sialadenitis development on the background and after radioiodine therapy. Twenty-eight patients (28/61) who had a lesion of the salivary gland on the background of ongoing therapy. A statistical analysis of data on gender, age, the main clinical diagnosis, the stage of the underlying disease, the received dose of I131, the presence or absence of sialadenitis, the time from the start of radionuclide therapy to the development of sialadenitis was carried out.

Results. When analyzing the data obtained, it was revealed that independent adverse factors that increase the risk of developing salivary gland lesions in patients who received at least one session of radioiodine therapy were: female (p = 0.0219; HR 10.38: 95% CI 1.40–76.84) and age 61 years and younger (p = 0.0004; HR 1.04: 95% CI 1.02–1.06). And the median of the total accumulated dose of the radiopharmaceutical did not show its significance in the multifactorial analysis.

Conclusion. The development of chronic sialadenitis on the background of radioiodine therapy is a multifactorial pathology. This pathology requires dynamic monitoring and preventive measures, especially the risk group (female and age 61 years and younger).
Comparative analysis of the parameters of local immunity of oral fluid and the duration of the course in children with systemic lupus erythematosus, juvenile scleroderma, juvenile dermatomyositis, juvenile idiopathic arthritis and systemic vasculitis
Authors: Skakodub A. A. , Kozlitina Yu. A. , Admakin O. I. , Geppe N. A. , Osminina M. K. , Petukhova A. I. , Shevlakova A. V.
Published: November 2024

Immunoglobulins are considered to be the main factor of specific antimicrobial protection of oral tissues.

The study was conducted on the basis of the University Children’s Clinical Hospital of the I.M. Sechenov First Moscow State Medical University of the N.F. Filatov Clinical Institute of Child Health, in the Department of Rheumatology. The study involved 316 children, with diseases: systemic lupus erythematosus (SLE), juvenile dermatomyositis (YDM), juvenile limited scleroderma (YOSD), juvenile systemic scleroderma (YSSD), juvenile idiopathic arthritis (JIA), systemic vasculitis (SV) and Behcet’s disease (BB) and were divided into age groups according to the duration of the course of the underlying disease. The analysis of the results revealed a decrease in the content of IgG, IgA, sIgA in saliva in children with rheumatic diseases in all age groups compared with the control group (children without somatic diseases). With the duration of the course of the disease up to 2 years, the most pronounced decrease in the content of IgG, IgA, sIgA in saliva was revealed, more than 4–10 times (p<0.05), and with a duration of more than 2 years, a decrease of 2–3 times (p<0.01), compared with the control group. The deficiency of these immunoglobulins shows that in children with rheumatic diseases, regardless of the nosology, there is a violation of the local immunity of the oral cavity, especially at the onset of the underlying disease (in groups up to 2 years of the duration of the course of the underlying disease), with pronounced autoimmune inflammation of tissues and blood vessels, and this is also facilitated by the reception, during this period of shock doses of glucocorticosteroids, cytostatics, immunosuppressors, which leads to severe inflammatory processes of the oral mucosa, periodontal and hard tissues of the teeth.
Clinical experience of tooth replantation
Authors: Ivashchenko A. V. , Yablokova A. E. , Tlustenko V. P.
Published: November 2024

Relevance.Modern dental practice strives, above all, to preserve teeth. A variety of operations aimed at this include dental replantation. Replantation is used in cases where there are difficulties with the root canals, such as their pathological bending or previous treatment with the resorcinol-formalin method, and also when root resection is impossible due to the risk of damage to surrounding structures, for example, the maxillary sinus or the inferior alveolar nerve.

The purposeof this study was to study the osseointegration of a replanted tooth subjected to coronoradicular separation.

Materials and methods.Thirty-one-year-old patient K. came to the dental clinic with the problem of pain in the projection of tooth 4.6, which occurs during chewing. A detailed examination revealed that the crown of tooth 4.6 had previously undergone restoration using a filling material that had defects. It was decided that tooth 4.6 should be removed and subsequently replanted. The tooth was extracted according to established procedures, while maximally preserving the surrounding periodontal and periosteal tissues. To preserve periodontal tissues, alveolar curettage was carefully performed. During the extraction of the tooth, it was longitudinally divided into two parts – the medial and distal roots. After this, the root canals were treated using extraoral therapy. The roots of tooth 4.6, treated with an antiseptic, were returned to their anatomical positions in the alveolus. The final stage was the creation of a control x-ray to verify the correctness of the replantation.

Conclusions.After two years of observation of tooth 4.6, which was subjected to replantation, no pathological changes in root stability were detected. It was reported that the soft tissue surrounding the roots of the tooth formed a structure similar to the periodontal sulcus, which facilitated the use of retraction cord during tooth preparation.
Covid-associated osteonecrosis of the midface
Authors: Fomichev E. V. , Yarygina E. N. , Kirpichnikov M. V. , Serbin A. S. , Efimova E. V. , Aleshanov K. A.
Published: November 2024

The purpose of our study the features of clinical manifestations and treatment of Covid-associated osteonecrosis of the midface (rhinocerebral form of mucormycosis). An analysis of the clinical features and results of surgical treatment of 35 patients with Covid-associated osteonecrosis of the midface was carried out. Difficulties in diagnosing of Covid-associated osteonecrosis led to late hospitalization and extensive surgical treatment with the huge defects formation. Due to the nonspecificity of clinical symptoms and the difficulties of early diagnosis and differential diagnosis of invasive rhinocerebral forms of mucormycosis, the aggressive clinical course with the formation of extensive defects in the midface, long and complex rehabilitation of patients with Covid-associated osteonecrosis of the midface, the vigilance of general practitioners is necessary and specialists: dental surgeons, maxillofacial surgeons, ophthalmologists, otolaryngologists, neurologists, regarding the possibility of developing invasive aggressive forms of mycoses in immunocompromised patients who have suffered a new coronavirus infection COVID-19.
Diagnostic significance of the method of computerized joint vibration analysis in studying the functional state of temporomandibular joints
Authors: Domenyuk D. A. , Boyko E. M. , Davydov B. N. , Kochkonyan T. S. , Domenyuk S. D.
Published: November 2024

polyetiology, progressive course and high frequency of relapses is one of the urgent problems of modern dentistry. Different conceptual approaches to the analysis of etiological and pathogenetic aspects of the development of dysfunctional TMJ disorders predetermine the increased interest in the search for highly informative diagnostic methods, especially at the stage of preclinical manifestations.

Goal. Evaluation of possibilities of computerized joint vibration analysis method in diagnostics of TMJ functional state.

Materials and methods. The study involved 42 people of both sexes with physiologic types of bite, preserved tooth rows, no signs of functional disorders in TMJ and masticatory muscles. The patients underwent clinical dental examination, «Hamburg test», selective grinding of teeth, and measurement of mouth opening amplitude. Joint vibration analysis was performed on the hardware-software complex «BioPAK» with registration of TMJ noise oscillations according to the following indices: «Total Integral», «High Integral», «Low Integral», «Ratio». A flow chart (Ishigaki S. et al., 1993) was used to interpret the numerical values. The functional state of TMJ was de-termined according to the flowchart using numerical parameters in accordance with the classification of TMJ disorders (Wilkes С.Н., 1989).

Results. In patients with physiologic occlusion, according to joint vibration analysis, Me «Total Integral» of the right TMJ was 11.7 PaHz, left TMJ – 12.6 PaHz, [Q-25; Q-75] – [9.3; 15.1] PaHz and [10.5; 18.3] PaHz respectively, Me «High Integral» of the right TMJ – 1.3 PaHz, left TMJ – 1.4 PaHz, [Q-25; Q-75] – [1.0; 1.8] PaHz and [1.2; 2.1] PaHz respectively, with no statistically significant (p≤0.05) differences in the studied parameters between the right and left TMJ.

Conclusions. The diagnosis of «structurally intact» TMJ, corresponding to stage I of the American classification of TMJ disorders (Wilkes S.N., 1989) in people with physiologic types of bite, is confirmed by the numerical values [Q-25; Q-75] of «Total Integral», «High Integral» (block diagram of S. Ishigaki et al., 1993), the degree of maximum mouth opening [43; 50] mm in the absence of pronounced signs of facial asymmetry.
Evaluation of efficiency of modern applicators
Authors: Khritova A. A. , Kopetski I. S. , Nikolskaia I. A. , Gileva I. Yu. , Khismonova M. Sh. , Kutyreva Э. И. , Gorina N. I.
Published: November 2024

Based on a review of the current literature and a survey of dentists, the following applicators were selected: Ipex (Nsk), Propex pixi (Dentsply), AirPex (Eighteeth), NanoEst (Geosoft), Raypex 6 (VDW). As a result of a retrospective study, the most effective work was shown by the applicator Propex pixi(Dentsply) – 96%, the device showed the least efficiency – AirPex(Eighteeth) – 80%.
The comorbid pathology in patients with chronic apical periodontitis
Authors: Bagryantseva N. V.
Published: November 2024

The purpose of this study was to study the relationship between teeth after endodontic treatment and/or with apical periodontitis, in patients with a number of systemic diseases and smokers among the adult population of Yaroslavl.

Materials and methods of research. Medical history data were collected, including age, gender, presence of cardiovascular diseases, diabetes mellitus, allergies, smoking habits and data on endodontic dental treatment of 421 patients (10,540 teeth). The prevalence of depulpated teeth and the periodontal condition were assessed by orthopantomograms. The periapical status was classified according to the periapical Index PAI (PAI), chronic apical periodontitis was defined as PAI-score ≥3. The statistical analysis was carried out using the Stata/MP v. program.17.0 (StataCorp LLC, Texas 77845-4512, USA) using chi-square tests, odds ratio and confidence intervals (95%).

The results and their discussion. The overall prevalence of chronic apical periodontitis and the prevalence of teeth after endodontic treatment was 2.2 and 4.2%, respectively. The high prevalence of depulpated teeth increased the likelihood of chronic apical periodontitis (p<0.0001). In the group of men, there was a higher percentage of teeth with chronic apical periodontitis (p<0.0001), a lower percentage of teeth after endodontic treatment (p=0.05) and a greater number of residual roots (with complete destruction of the crown of the tooth) (2.3%). Smokers were more likely to have teeth with chronic apical periodontitis (p=0.002) and the prevalence of teeth after endodontic treatment (p=0.045). A positive correlation was observed between the prevalence of teeth after endodontic treatment and diabetes mellitus (p=0.040).

Conclusion. A higher prevalence of chronic apical periodontitis and/or teeth after endodontic treatment in smokers and patients with diabetes mellitus may indicate a relationship between the condition of the oral cavity and a number of systemic diseases.
Photodynamic therapy – modern views and innovations in dentistry
Authors: Risovannaya O. N. , Andreasyan T. Sh.
Published: November 2024

Photodynamic therapy (PDT) consists of three elements: a photosensitizer, light and oxygen. The photosensitizer has the property of selective accumulation in target tissues without harming healthy cells. This innovative therapeutic method has already been successfully adapted in many areas of medicine, such as dermatology, gynecology, urology and oncology. PDT is also beginning to be introduced in dentistry. The antibacterial and fungicidal properties of the photosensitizer are used to achieve better results in the medical and surgical treatment of patients.

Objective. To analyze current scientifi   data on the application of photodynamic therapy (PDT) in various fi   of dentistry, evaluate its effectiveness, and assess prospects for development.

Materials and methods. A review of recent scientifi literature was conducted, including original studies, systematic reviews, and meta-analyses focused on PDT application in dentistry. Data on mechanisms of action, clinical efficacy, and new developments in PDT were analyzed.

Results. High effi of PDT was established in the treatment of periodontal diseases, peri-implantitis, endodontic infections, and oral oncological diseases. Advantages of combined application of PDT with other treatment methods were noted. Promising directions for PDT development were identifi     including the creation of new photosensitizers and technological innovations in equipment.

Conclusions. PDT is a promising treatment method in dentistry, demonstrating high efficacyand safety. Further research is aimed at optimizing treatment protocols, developing personalized approaches, and integrating PDT with other modern technologies.
Optimizing the treatment of patients with intrinsic temporomandibular joint disorders
Authors: Kazarian G. G. , Bekreev V. V. , Kladnichkin I. D. , Salekh K. M. , Degtyarev N. E.
Published: November 2024

Temporomandibular joint (TMJ) dysfunctions are conditions in which there is a disruption in the anatomical and functional relationship between the various structures of the joint, including the articular disc, intra-articular ligaments, mandibular head and capsule. These disorders have a negative impact on the patient’s quality of life, resulting in limitations in masticatory function and articulation. The multifactorial nature of this pathology emphasizes the need for an individualized and comprehensive approach to the treatment of each patient. In most cases, treatment includes both surgical and orthopedic methods. Currently, combined treatment approaches aimed at synergistic effects are being actively developed to maximize therapeutic

Results.

The purpose of this study. To evaluate the efficacy of the combination of treatment with a repositioning mouthguard and the use of the hydraulic articular disk repositioning method in patients with internal TMJ disorders combined with dental row end defects.

Materials and methods. The study included 6 patients with TMJ dysfunction and end defects of the dentition. The study was conducted between September 2023 and May 2024. As part of the study, each patient underwent cone beam computed tomography (CBCT) to evaluate the bony structures of the TMJ and ultrasound (US) to evaluate the soft tissue structures of this joint.

Results. The CBCT data showed that the mean posterior temporomandibular joint displacement before treatment was 1.67, while this value increased to 3.02 after treatment. The US results showed a significant decrease in the mean value of mandibular head displacement after treatment ranging from 0.21 to 0.03, indicating a positive effect of treatment. In addition, there was a decrease in the difference in the size of the anterior and posterior parts of the articular disc, confirming the elimination of its displacement.

Conclusion. The treatment combination of using a repositioning mouth guard with the hydraulic repositioning method brought about a synergistic effect on the restoration of TMJ function.
The effectiveness of the HB&L system in bacteriuria determining
Authors: Kolupaev V. E.
Published: November 2024

Urinary tract infections (UTIs) are characterized by high prevalence in various populations, recurrent course, complications and accumulation of antibiotic resistant strains. Researchers continue to search for objective criteria for the laboratory diagnosis of associated diseases, including methods for determining bacteriuria The implementation of anautomatic bacteriological analyzer into the laboratory practice would make possible to organize screening studies of UTIs with high sensitivity and specificity, in parallel with studies of the resistant phenotypes’prevalence. This will help to create the basis for the development of highly effective and reasonable antibiotic therapy, and, in general, to improve the epidemiological situation associated with these infections.
Investigation of hematological, biochemical and coagulological markers, their diagnostic effectiveness in toxic hepatitis in patients with COVID‑19
Authors: Molodova A. I. , Pavlov A. I. , Kazakov S. P. , Karakozov A. G.
Published: November 2024

This article discusses hematological, biochemical and coagulological markers for the diagnosis of toxic hepatitis in patients with COVID-19. The analysis of the effectiveness of these markers in a large sample of patients confirmed their importance for the early detection of toxic hepatitis b in patients with COVID-19. Blood parameters such as platelets, ALT, AST, bilirubin, as well as coagulograms and markers of protein metabolism (albumin) conducted among patients divided into control and experimental groups were analyzed. It was found that in patients with concomitant toxic hepatitis c COVID-19, the tendency of thrombocytopenia is most common in clinical blood analysis. Among the biochemical parameters of blood, liver markers increase (ALT, GGT, alkaline phosphatase, etc.). It should be noted that in 1/3 of patients, the activity of liver enzymes alanine aminotransferase and aspartate aminotransferase increases, which indicates a violation of liver function.The analysis of these data using ROC analysis showed high diagnostic accuracy of these markers in the detection of toxic hepatitis in patients with COVID-19. These studies may be important for more effective screening and further monitoring of appropriately selected treatment in such clinical situations and contributes to more effective management of this condition, leading to an improved prognosis of this disease. This study is important in the context of understanding the effects of COVID-19 on liver function.
Reference TSH intervals in children and adolescents
Authors: Kuznetsova V. S. , Efimushkina O. A. , Mudrov V. P. , Shumilkina I. S.
Published: November 2024

The determination of thyroid-stimulating hormone (TSH) is a reliable test in the diagnosis of thyroid dysfunction. When interpreting the results of quantitative studies, clinicians and laboratory specialists most often resort to assessing the compliance of the result with reference intervals (RI). At the same time, each laboratory must determine them for the analytes being measured itself, based on the characteristics of the examined contingent, the characteristics of the analytical systems used, achieving the necessary diagnostic effectiveness of the methodology, and its own practical and economic capabilities. A retrospective analysis of TSH results obtained from patients under the age of 19 years was performed for 54970 patients without hypothyroidism, thyrotoxicosis and pituitary disorders. For this work, reagent kits “Roche Cobas”, “Mindray” and “Beckman Coulter” (ICLA) were used. As a result, RI was established for the study of TSH for three sets of reagents with appropriate equipment and for four age groups: 1 day – 6 months, 6 months – 7 years, 7–14 years, 14–19 years. This makes it possible to use RI as a screening for possible developmental pathology in childhood and to determine the limits of clinical decisions.
Modernized coagulometers APG2–03‑P, APG2–03‑Ph, APG4–03‑P, APG4–03‑Ph with an extended list of performed coagulation tests
Authors: Kutepov M. V. , Selivanov D. B. , Stankevich V. I. , Suleimanov A. P. , Mestergazi A. V. , Chernov P. M.
Published: November 2024

The key distinctive features and application opportunities of the upgraded semi-automatic coagulometers APG2–03-P, APG2–03-Ph, APG4–03-P, APG4–03-Ph are described.
Interpretation of reference intervals and clinical decision limits
Authors: Berestovskaya V. S. , Emanuel A. V. , Skibo I. I. , Emanuel V. L.
Published: November 2024

Reference intervals (RI) and clinical decision limits (CDL) are an important part of th e medical information needed to interpret the results of a laboratory tests. The emphasis is on the need to distinguish between the two concepts. RI allows to assess the compliance of the patient’s result with the values detected in a healthy population with a certain probability. CDL is associated with specific diseases and medical risks and may be more significant for clinical decision-making than RI. When interpreting RI and CDL, it is necessary to take into account the possibility of divergence of results on different analytical systems as a potential source of erroneous medical decisions.
Liquid biopsy: the analysis of circulating tumour DNA
Authors: Shcherbo D. S. , Koval A. P. , Shcherbo S. N. , Savina M. I. , Turkina T. I.
Published: November 2024

Circulating tumour DNA (ctDNA) fragments found in blood represent a critical source of information about the tumour. However, the analysis of ctDNA is challenging due to the overwhelming presence of DNA from non-malignant cells and requires the development of highly sensitive laboratory techniques. This review discusses the major categories of ctDNA biomarkers, their detection methodologies, and explores the potential of emerging technologies within the liquid biopsy field.
Mini-review on laser-induced nanoparticle heating and melting
Authors: Baimler Ilya V. , Simakin Alexander V. , Dorokhov Alexey S. , Gudkov Sergey V.
Published: November 2024

The development of various nanomaterials production technologies has led to the possibility of producing nanoparticles (NPs) and nanostructures, which can find a wide range of applications, from the fabrication of microelectronic devices to the improvement of material properties and the treatment of cancer. The unique characteristics of nanoparticles are primarily due to their small size, which makes size control important in their preparation. Modification of nanoparticles by laser irradiation and obtaining desired nanoparticle properties is a promising approach because of its ease of implementation. The purpose of this review is to analyze the works devoted to the study of laser-induced heating and melting of nanoparticles, to collect information and evaluate the results of using this method for functionalization and modification of metallic nanoparticles, and to discuss promising directions for the use of this technique.
Isotopic analysis of modern sorghum and finger millet from different altitudes in Ethiopia: implications for ancient farming practices
Authors: Varalli Alessandra , Beldados Alemseged , D'Agostini Francesca , Mvimi Malebogo , D'Andrea Catherine , Lancelotti Carla
Published: November 2024

C4 crops such as sorghum (Sorghum bicolor) and finger millet (Eleusine coracana) have played a significant role in the economic livelihood in arid and semi-arid zones of tropical and sub-tropical Africa since prehistoric times. However, to date, our knowledge of their past management practices is limited. Stable isotope analysis of archaeobotanical remains has been recognized as a valuable tool for reconstructing past agricultural practices, e.g. water management, and fertilization. Nonetheless, our limited understanding of the isotopic variability of C4 plants calls for further research on modern plant before application to archaeobotanical remains. In this paper, we aim to enhance our understanding of modern C4 botanical remains' isotopic variability by analyzing sorghum and finger millet plants. These crops were cultivated according to traditional local practices and collected from ten villages located in the Konso Zone (South Ethiopia) and Tigray Regional State (North Ethiopia), where they are among the daily ingredients for food, and traditional alcoholic and non-alcoholic drinks. We analyzed carbon and nitrogen stable isotopes of seeds and biosilica content in chaff, as it has been suggested that a relationship can exist between silicon and C:N. Carbon isotope values show significant variability, positively correlated with altitude. By demonstrating the sensitivity of C4 grain carbon stable isotope to altitude variations, which are likely connected to water availability, this study offers invaluable insights for the accurate assessment of isotopic values derived from ancient C4 crops. The absence of significant correlations with δ15N suggests that nitrogen isotope values may be less effective for understanding environmental variations in this kind of context. This highlights the limitations of nitrogen isotope data for interpreting ancient agricultural practices and underscores the importance of relying more on carbon isotopes for insights related to environmental conditions and altitude. Furthermore, we confirm that the amount of assimilated carbon may depend also on the biosilica content, which is in turn modulated by environmental parameters such as water availability or soil silicon levels.