bluuebunny/crossref_metadata_2025 huggingface dataset:
Tourism gentrification and neighbourhood transformation
Authors: Lo Jamie Siu Kam , McKercher Bob
Published: September 2023

Purpose

This study aims to examine the process of tourism gentrification from China tourists, a major source market, in two neighbourhoods in Hong Kong: one that has been long exposed to tourism and one that is just being discovered by tourists. Through a series of in-depth interviews with local residents and community leaders, complemented by non-participant observation, the paper tracks the commercial, social and cultural changes that have occurred or are occurring in these two places.

Design/methodology/approach

This study evaluates the process of place change through tourism gentrification in two neighbourhoods in Hong Kong that are at different stages of the process. An ontological approach is adopted using an interpretivist paradigm involving in-depth interviews and on-site observations, supplemented by secondary data. These data were complemented by non-participant observation.

Findings

Both the places have been transformed due to the influx of mainland Chinese tourists. Some impacts felt by both communities have much in common, such as congestion and shop dislocation, while others are more location specific. Even though the degree of tourism gentrification is different, locals from both locations tend to hold negative perceptions towards tourists, although of different strengths. All have also noted the traditional social cohesion is not as strong as before.

Originality/value

The paper argues that tourism gentrification exists on a continuum as neighbourhoods move seemingly inextricably from local-centric nodes to tourist-centric nodes. Apart from enlightening the theory of tourism gentrification, it provides insights to the local leaders on proper tourism development by balancing the social and economic benefits.
Use of emerging social media platforms in reshaping the UAE Islamic banks’ promotional strategies
Authors: Muhammad Abid Mahmood , Basha Mohamed Bilal , AlHafidh Gail
Published: September 2023

Purpose

This paper aims to investigate customer attitude towards the use of emerging social media platforms (SMPs) for promotional activities by United Arab Emirates (UAE)-based Islamic banks, particularly, in the post-COVID-19 era. The key drivers of this research include analysing, anticipating and providing recommendations to reinvigorate the marketing and promotional strategies of the UAE Islamic banks to spark renewed customer interest.

Design/methodology/approach

This study is anticipatory and descriptive in nature. Primary data is used to understand customer perception towards the use of emerging social media marketing tools by the UAE-based Islamic banks. Reliability, factor analysis and multiple regression analysis are applied to understand customer attitude. While focusing on the current COVID-19 scenario, the need for innovative structure is envisaged to meet the post-COVID-19 needs.

Findings

The findings of this research highlight the significance of emerging SMPs such as WhatsApp, TikTok, Pinterest, Viber, Snapchat and their application as promotional tools to inspire the purchase intention of customers in this virtual age. The results of the study reveal these emerging SMPs are predicted to be used as the preferred promotional tools for Islamic banks.

Research limitations/implications

This paper is limited to the UAE Islamic banks and to a specified set of SMPs as promotional tools. Nevertheless, its findings have important implications that can be extended and validated through studying the post-COVID-19 customer attitude towards other innovative promotional tools used by commercial banks in general and Islamic banks in particular, in the GCC and Middle East and North Africa (MENA) regions.

Originality/value

There is currently limited available research on the innovative social media marketing techniques and promotional strategies. This study is a novel attempt to examine the adoption of the emerging SMPs as promotional tools by the UAE Islamic banks. This paper extends value to the existing studies on the impact of the pandemic on the promotional activities of the UAE Islamic banking industry. Nonetheless, while regionally specific, it is valuable in its potential application to the Islamic banking sector in the entire GCC and MENA region in the post-COVID-19 era.
Fostering innovation capability and sustainable innovation in halal industry: the role of halal entrepreneurs’ success
Authors: Salaheldeen Mohamed , Battour Mohamed
Published: September 2023

Purpose

This study aims to conceptualize and investigate the relationships between halal entrepreneurial success, innovation capability and sustainable innovation in the halal industry.

Design/methodology/approach

Both integrative and generative approaches are combined to move forward from the literature to a theoretical contribution. The paper presents a model that relates halal entrepreneurial success to innovation capability and sustainable innovation. A purposive sample of 340 Malaysian halal entrepreneurs is used to test the conceptualized model. The partial least square technique was then used to assess the structural model.

Findings

The results disclosed that halal entrepreneurial success is positively related to both innovation capability and sustainable innovation. Also, the innovation capability mediates the relationship between halal entrepreneurial success and sustainable innovation.

Originality/value

This research conceptualized and examined a novel model that assesses the relationships between halal entrepreneurial success, innovation capability and sustainable innovation in the halal industry.
Proportional appropriation systems and financial statement quality in municipally owned entities: empirical evidence from Italy
Authors: Capalbo Francesco , Galati Luca , Lupi Claudio , Smarra Margherita
Published: September 2023

Purpose

This paper aims to examine how proportional appropriation systems affect the quality of financial reporting in entities controlled by local governments.

Design/methodology/approach

The authors examine this issue using the setting of Italian municipally owned entities (MOEs) following the implementation of a new accounting regulation that limits the spending power of the participating municipality when the owned entity reports losses. The authors apply Benford's law on net income figures using the Chi-square and Z-tests on the adjusted version of the Mean Absolute Deviation (MAD) criterion to spot any sign of low data quality. The sample, which consists of 2,120 MOEs, covers the years 2010–2019 and is evenly divided into the periods pre- and post-policy introduction.

Findings

Widespread data anomalies were detected following the introduction of the new regulation for MOEs controlled by local governments. Evidence is stronger for entities owned entirely by municipalities. The results suggest that the extent of data manipulation grows as the municipality's ownership stake increases, consistent with the hypothesis that a decrease in spending power through the appropriation of financial resources affects earnings management practices in municipally controlled entities.

Practical implications

This paper sheds light on government-based accounting policies by documenting evidence of somewhat inefficient responses by those responsible for the preparation of financial statements on behalf of municipally owned entities, and, accordingly, insights are provided to help review these policies so as to forestall even indirectly detrimental repercussions on public services.

Originality/value

This paper extends prior research in public-sector earnings management by being the first to test whether MOEs manipulate their earnings as a consequence of participating municipalities' reduced spending capability. Understanding factors influencing earnings management practices driven by governments, other than political incentives, is still an open issue.
Understanding the role of customer incivility and supervisor monitoring in the relationship between customer orientation and frontline employees' emotional exhaustion
Authors: Xie Fang , Zhang Xufan , Ye Jing , Zhou Lulu , Zhang Wenjian , Tian Feng
Published: September 2023

Purpose

Based on the resource conservation theory, this research paper aims to evaluate the positive impact of customer orientation on frontline employees' emotional exhaustion and the moderating effects of customer incivility and supervisor monitoring.

Design/methodology/approach

Two-wave data from 484 frontline employees in power supply business halls were analyzed. This study used AMOS 23.0, SPSS22.0 and PROCESS macro for data statistics and analysis.

Findings

Our empirical research demonstrates that customer orientation has a significant positive impact on frontline employees' emotional exhaustion. At the same time, supervisor monitoring moderates the relationship between customer orientation and emotional exhaustion. The higher the interactional or observational monitoring, the stronger customer orientation's effect on frontline employees' emotional exhaustion. Moreover, a three-way interaction model exists between customer orientation, customer incivility and supervisor monitoring.

Practical implications

This study yields practical implications for helping the frontline employees of service-oriented organizations alleviate multiple interpersonal workplace pressures.

Originality/value

Based on resource conservation theory, this paper used a novel approach to focus on customer orientation, customer incivility and supervisor monitoring as interpersonal stressors.
Predicting customer deposits with machine learning algorithms: evidence from Tunisia
Authors: Gafrej Oussama
Published: September 2023

Purpose

This paper aims to evaluate the performance of the multiple linear regression (MLR) using a fixed-effects model (FE) and artificial neural network (ANN) models to predict the level of customer deposits on a sample of Tunisian commercial banks.

Design/methodology/approach

Training and testing datasets are developed to evaluate the level of customer deposits of 15 Tunisian commercial banks over the 2002–2021 period. This study uses two predictive modeling techniques: the MLR using a FE model and ANN. In addition, it uses the mean absolute error (MAE), R-squared and mean square error (MSE) as performance metrics.

Findings

The results prove that both methods have a high ability in predicting customer deposits of 15 Tunisian banks. However, the ANN method has a slightly higher performance compared to the MLR method by considering the MAE, R-squared and MSE.

Practical implications

The findings of this paper will be very significant for banks to use additional management support to forecast the level of their customers' deposits. It will be also beneficial for investors to have knowledge about the capacity of banks to attract deposits.

Originality/value

This paper contributes to the existing literature on the application of machine learning in the banking industry. To the author's knowledge, this is the first study that predicts the level of customer deposits using banking specific and macroeconomic variables.
Unveiling consumer behavior in marketing: a meta-analytic structural equation modeling (Meta-SEM) of the model of goal-directed behavior (MGB)
Authors: Vishwakarma Pankaj , Mohapatra Malaya Ranjan
Published: September 2023

Purpose

Understanding consumer behavior across various contexts within marketing has long been the focus of studies. Although many models are used in explaining consumers' behavior, one of these is the Model of Goal-Directed Behavior (MGB), which is becoming prominent in explaining consumers' behavior in marketing. Given its popularity, prior research on MGB has shown inconsistent outcomes regarding the casual association of MGB variables. To overcome this, the authors have adopted a meta-analytic review of the marketing studies grounded on MGB theory in examining the consumers' behavior.

Design/methodology/approach

The study reviewed and analyzed 611 correlations from 27 studies with 31 samples (combined sample size of 9588) using a meta-analytic structural equation modeling (MASEM) technique.

Findings

The outcomes of MASEM confirm the significance of all the proposed relationships in the MGB model. However, the attitude has shown a strong influence on desire formation among all the proposed MGB relationships. Further, past buying experience and positive anticipated emotions strongly affect desire in developed nations compared to developing nations.

Research limitations/implications

The current work has considered the possibility of various recommended moderators (e.g. culture, crisis situation, sample size, method of data collection, etc.); however, the study lacks to consider the dimension of gender dominance in it. Hence, future researchers should keep it in mind while conducting similar studies. Future scholars can also perform a comparative study on MGB across the domains and subdomains to know more insights.

Originality/value

The current work offers a better understanding of MGB application in marketing. As this work is one of the first meta-analyses on MGB application in marketing that also considers the effect of various moderators, it thus adds knowledge to the literature on MGB in marketing. It will also help the future researchers to understand MGB as a framework and its application in marketing.
Exploring Arab researchers' research data sharing and requesting practices: a survey study
Authors: Subaveerapandiyan A. , Amees Mohammad , Annamma Lovely M. , Yadav Upasana , Mushanga Kapata
Published: September 2023

Purpose

This survey-based study aims to explore the research data dissemination and requesting practices of Arab researchers. It investigates the reasons, types, methods, barriers and motivations associated with data sharing and requesting in the Arab research community.

Design/methodology/approach

A cross-sectional survey was conducted with 205 Arab researchers representing various disciplines and career stages. Descriptive statistics were used for data analysis.

Findings

The study found that 91.2% of Arab researchers share data, while 56.6% access data from others. Reasons for sharing include promoting transparency and collaboration while requesting data is driven by the need to validate findings and explore new research questions. Processed/analysed data and survey/questionnaire data are the most commonly shared and requested types.

Originality/value

This study contributes to the literature by examining data sharing and requesting practices in the Arab research community. It provides original insights into the motivations, barriers and data types shared and requested by Arab researchers. This can inform future research and initiatives to promote regional data sharing.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/OIR-06-2023-0283
Saudi teachers' perspectives on flipped learning: Are they ready and willing?
Authors: Rajeh Hamzah S.
Published: September 2023

Purpose

Incorporating flipped learning (FL) into teaching English as a foreign language may improve student learning outcomes. This study gathered information on Saudi EFL teachers' readiness and willingness to apply FL. So, it aims to describe Saudi EFL teachers' readiness and willingness to apply FL in language classrooms and to find suitable guidelines for Saudi EFL professional development (PD) designers to follow.

Design/methodology/approach

This descriptive study involved 153 male and female Saudi EFL teachers as participants, investigating the perspectives and perceptions of these teachers within the context of foreign language teaching in Saudi Arabia. Surveys in Qualtrics were employed as the primary data collection tool for the study.

Findings

Results showed that teachers' self-efficacy of their current teaching was high. Most participants had positive attitudes and abilities related to FL, although they also identified potential challenges related to its engagement and assessment. Teachers expressed a strong willingness to participate in PD in this area, with a preference for online videos and group workshops.

Originality/value

The study emphasizes the importance of PD for Saudi EFL teachers. In addition, it offers guidelines for planning effective PD.
That Monster Over There: Silvia Kolbowski, Trump, and Allegory
Authors: Knapp Ivan
Published: September 2023

This essay considers the ways in which Silvia Kolbowski's 2018 video That Monster: An Allegory addresses the psychical and political basis of Donald J. Trump's appeal in the 2016 US election. The video is crafted out of a collection of fragments from James Whale's 1935 The Bride of Frankenstein, which Kolbowski plays first with a score by Philip Glass and then in silence. This article asks how such a format might illuminate resonances between certain psychoanalytic concepts and the postmodernist discourse of allegory as exemplified in the work of Paul de Man and Craig Owens. I argue that these theoretical frameworks help us to retain an open reading of Kolbowski's allegory which shifts an interpretive focus from questions of identity to problems of repetition, refusal, and erasure.
Routine
Authors: Warren Jonathan
Published: September 2023

Written a year and a half into the pandemic during a particularly difficult week, this poem explores the moral injury and emotional distress that emergency physicians encounter and must process daily. These repeated microtraumas throughout our day frequently contribute to depersonalization and it is important to recognize those factors that “break the routine” and help to improve physician well‐being.
Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics
Authors: Billaux Pauline , Maurage Pierre , Cabé Nicolas , Laniepce Alice , Segobin Shailendra , Pitel Anne‐Lise
Published: September 2023

Functional neuroimaging has demonstrated the key role played by the insula in severe alcohol use disorder (sAUD), notably through its involvement in craving and body signals processing. However, the anatomical counterpart of these functional modifications in sAUD patients with and without neurological complications remains largely unexplored, especially using state‐of‐the‐art parcellation tools. We thus compared the grey matter volume of insular subregions (form anterior to posterior: anterior inferior cortex, anterior short gyrus, middle short gyrus, posterior short gyrus, anterior long gyrus, posterior long gyrus) in 50 recently detoxified patients with sAUD, 19 patients with Korsakoff's syndrome (KS) and 36 healthy controls (HC). We used a mixed linear model analysis to explore group differences in the six subregions grey matter volume and lateralization differences. Insular macrostructure was globally affected to the same extent in sAUD with and without KS, indicating that these brain abnormalities may be related to alcohol consumption per se, rather than to the presence of alcohol‐related neurological complications. Insular atrophy showed a right‐sided lateralization effect and was especially marked in the posterior insula, a region associated with visceral information processing and the embodiment effect of a substance, from which craving arises. Anatomical damages might thus underlie the previously reported altered insular activations and their behavioural counterparts.
Review of the caroticotympanic nerves: Anatomy, function and pathology
Authors: Albuck Aaron L. , Techabunyart Daniel B. , Cardona Juan J. , Chaiyamoon Arada , Tsang Preston , Iwanaga Joe , Dumont Aaron S. , Tubbs R. Shane
Published: September 2023

The caroticotympanic nerves provide postganglionic sympathetic fibres to the tympanic plexus. However, there are scant reports in the literature detailing with these nerves in great depth. As the caroticotympanic plexus lies near the often‐operated tympanic nerve, it is important for the surgeon to understand the anatomy, pathology and surgical implications of it. Here, we present a review of the available literature regarding the caroticotympanic nerves.
Preoperative chronic kidney disease and complications after pancreatoduodenectomy: a retrospective cohort study
Authors: Swartling Oskar , Evans Marie , Larsson Patrik , Perri Giampaolo , Yarbakht Danial , Al‐Kamil Hussein , Gilg Stefan , Holmberg Marcus , Sparrelid Ernesto , Ghorbani Poya
Published: September 2023

Background

Chronic kidney disease is a prevalent condition in surgical patients. Possible associations with increased postoperative morbidity and mortality have not been clearly demonstrated in patients undergoing pancreatoduodenectomy. The aim of this study was to assess the risk of postoperative complications in patients with reduced kidney function undergoing pancreatoduodenectomy.

Methods

All patients undergoing pancreatoduodenectomy at Karolinska University Hospital between 2008 and 2019 were retrospectively included. The variable of interest was chronic kidney disease, based on preoperative estimated glomerular filtration rate measurements. Unadjusted and adjusted logistic regression analyses were performed for standardized postoperative complications.

Results

A total of 971 patients were included in the study, of whom 92 (10%) had an estimated glomerular filtration rate < 60 mL/min/1.73m2, equivalent to chronic kidney disease Stage 3a or worse. Patients with chronic kidney disease had a higher odds of longer hospital stay (adjusted odds ratio 1.58, 95% confidence interval 1.00–2.50) and postoperative weight increase (adjusted odds ratio 2.02, 1.14–3.56). A 10 unit increase of preoperative estimated glomerular filtration rate was associated to lower odds of intensive care unit admission (adjusted odds ratio 0.81, 0.69–0.95), delayed gastric emptying (adjusted odds ratio 0.90, 0.81–0.99), and post‐operative pancreatic fistula (adjusted odds ratio 0.83, 0.74–0.94).

Conclusion

Patients undergoing pancreatoduodenectomy with decreased preoperative kidney function are more likely to experience major postoperative complications, and also postoperative weight increase. Preoperative kidney function assessment is important in risk stratification before pancreatoduodenectomies.
Are we ready for translational research based on material and data from the Danish CancerBiobank and can we gain new knowledge from biobank registration?
Authors: Høgdall Estrid V.S. , Christensen Ib Jarle , Høgdall Claus
Published: September 2023

Bio‐and GenomeBank, Denmark (RBGB) is a nationwide infra‐structure. Danish CancerBiobank (DCB) is a biobank in RBGB. The aim is to describe the degree of biological material collected and stored in DCB for patients diagnosed with primary ovarian cancer registered in The Danish Gynecologic Cancer Database (DGCD). Furthermore, to investigate the concordance between predicted organ of disease registered in RBGB at time of sampling (presumed diagnosis) with final diagnosis for patient. Data extraction from DGCD and DCB. Biological materials are present for 1.347 (62%) of 2.172 patients with primary ovarian cancer (OC). The median age of OC patients were 68 years (range: 18–90 years). Median age of patients with biological material in DCB was 67 years and for patients without biological material in DCB 69 years (p ≤ 0.0001). The histological subtypes for the 1347 OC patients with biological material were 911 (68%) serous adenocarcinoma, 97 (7%) endometrioid adenocarcinoma, 80 (6%) mucinous adenocarcinoma, 58 (4%) clear cell carcinoma, and for 201 (15%) no information were registered. For 327 patients (24%), the presumed diagnosis was hematological with a final diagnosis of OC. Using clinical data and biological material including pre‐analytical data regarding the biological material the possibility for translational research is optimal. Furthermore, information registered through daily working procedures may propose the need for additional biomarkers to aid clinicians to stratify patients to treatment in correct fast‐track packages.
Letter: future studies of high‐dose thiamine should consider whether its effects on fatigue are related to the inhibition of carbonic anhydrase isoenzymes. Authors' reply
Authors: Bager Palle , Hvas Christian , Rud Charlotte , Dahlerup Jens
Published: September 2023

LINKED CONTENT

This article is linked to Bager et al and Lubell papers. To view these articles, visit https://doi.org/10.1111/apt.16166 and https://doi.org/10.1111/apt.16275
Review article: comprehensive analysis of cirrhotic cardiomyopathy
Authors: Chahal Daljeet , Liu Hongqun , Shamatutu Chris , Sidhu Hasrit , Lee Samuel S. , Marquez Vladimir
Published: September 2023

Background

Patients with cirrhosis are at risk of developing cirrhotic cardiomyopathy. This syndrome is unique to cirrhosis and is generally defined as subnormal cardiac function in the absence of prior heart disease. There is no systematic or comprehensive review of cirrhotic cardiomyopathy to date.

Aims

To comprehensively review the literature on the definition, pathogenic mechanisms, diagnostic criteria, prevalence, management and influence on liver transplantation including reversibility of cirrhotic cardiomyopathy.

Methods

Electronic searches of the EMBASE, MEDLINE, EBM Reviews—Cochrane Central Register of Controlled Trials, EBM Reviews—Cochrane Database of Systematic Reviews and Google Scholar databases were conducted. MeSH terms focused on cirrhosis, cardiomyopathy, medication classes and epidemiology. Literature up to August 2020 was reviewed.

Results

New diagnostic criteria for the definition of cirrhotic cardiomyopathy have recently been published, consisting of systolic and diastolic dysfunction parameters as assessed by echocardiographic methods. The roles of electrocardiographic disturbances and biomarkers in the definition criteria remain unclear. Pathogenic mechanisms underlying cirrhotic cardiomyopathy are likely related to the inflammatory phenotype of cirrhosis. Prevalence rates of 26%‐81% in cirrhotic patients are reported. Several medical therapies have been proposed, but none with clear evidence of efficacy. The presence of cirrhotic cardiomyopathy complicates the liver transplantation process with a higher risk of adverse cardiovascular events post‐transplant. Complete reversibility of the syndrome after transplantation remains controversial but most studies suggest that it does not occur at least within the first post‐operative year.

Conclusions

Cirrhotic cardiomyopathy is a clinically relevant syndrome that affects morbidity and mortality in patients with cirrhosis.
Review article: investigation and management of internal fistulae in Crohn’s disease
Authors: Tjandra Douglas , Garg Mayur , Behrenbruch Cori , McCormick Jacob , Simkin Paul , Prentice Ralley , Trinh Andrew , Al‐Ani Aysha , Vaughan Rose , Macrae Finlay , Christensen Britt
Published: September 2023

Background

Crohn’s disease is an inflammatory, penetrating intestinal disease associated with fistula formation. Fistulae in Crohn’s disease can be classified into external and internal fistulae. Internal fistulae form between the gastrointestinal tract and another internal organ and include enteroenteric, enterocolic, enterovesical and rectovaginal fistulae. They are associated with significant morbidity and a decreased quality of life.

Aim

To review the classification, diagnosis, medical and surgical management of internal fistulae in Crohn’s disease, and propose a treatment algorithm.

Methods

A literature review on internal fistulae in Crohn’s disease in the adult population was undertaken, synthesised and summarised.

Results

Internal fistulae occur in up to 15% of patients with Crohn’s disease. Multi‐modal assessment including a combination of endoscopy and cross‐sectional imaging, usually magnetic resonance, is required to diagnose fistulae and determine extent of disease. Determining optimal treatment strategies for these complex fistulae remains a challenge due to limited and generally low‐quality data. Most studies to date have focussed on luminal disease, with (usually post hoc) outcomes more often reported for external fistulae, particularly perianal fistulae, than internal fistulae. Anti‐tumour necrosis factor therapies have emerged as the mainstay of medical therapy, with particularly promising data for enterovesical fistulae, but many patients will still require surgical intervention. The indications and optimal timing of surgery vs medical therapy remains uncertain; thus multi‐disciplinary input when making such decisions is important.

Conclusions

Internal fistulae result in significantly increased morbidity in Crohn’s disease, and further studies to determine optimal multi‐modality management strategies incorporating medical and surgical therapy are required.
Letter: increased incidence of tissue transglutaminase antibody in Israel—is it always related to coeliac disease? Authors' reply
Authors: Ben Tov Amir , Chodick Gabriel , Cohen Shlomi , Lechtman Niva , Shamir Raanan
Published: September 2023

LINKED CONTENT

This article is linked to Lechtman et al and Beenet and Tonesi papers. To view these articles, visit https://doi.org/10.1111/apt.16282 and https://doi.org/10.1111/apt.16320
Velusetrag accelerates gastric emptying in subjects with gastroparesis: a multicentre, double‐blind, randomised, placebo‐controlled, phase 2 study
Authors: Kuo Braden , Barnes Chris N. , Nguyen Deanna D. , Shaywitz David , Grimaldi Maria , Renzulli Cecilia , Canafax Daniel , Parkman Henry P.
Published: September 2023

Background

Gastroparesis is a serious gastrointestinal (GI) condition characterised by delayed gastric emptying (GE). Velusetrag—a potent, selective, pan‐gastrointestinal 5‐hydroxytryptamine type 4 receptor agonist—is under investigation for treatment of GI motility disorders including gastroparesis.

Aims

To assess the efficacy and safety of velusetrag for accelerating GE in subjects with diabetic or idiopathic gastroparesis.

Methods

In this multicentre, randomised, double‐blind, placebo‐controlled, three‐period fixed‐sequence crossover phase 2 study, subjects with diabetic or idiopathic gastroparesis received oral velusetrag (5, 15 or 30 mg) or placebo once daily for 7 days each. The primary outcome was proportion of subjects achieving ≥20% reduction in GE half‐time (GE t1/2) from each treatment period baseline on day 7. Absolute and percent changes from baseline GE t1/2 were also assessed. GE was measured using a [13C]‐octanoate breath test. Safety was evaluated from treatment‐emergent adverse events (TEAEs).

Results

Thirty‐four subjects (67.6% female; mean age, 46.3 years; 52.9% with diabetic gastroparesis) were included. Treatment with velusetrag 30 mg significantly increased the proportion of subjects with ≥20% reduction from baseline GE t1/2 compared with placebo (52% vs 5%, P = 0.002), and GE t1/2 was numerically reduced following all three doses of velusetrag relative to placebo treatment. Efficacy was similar between subjects with diabetic and idiopathic gastroparesis. Velusetrag treatment was generally well tolerated; most TEAEs were mild and related to GI transit acceleration.

Conclusions

Velusetrag accelerates GE in subjects with diabetic or idiopathic gastroparesis and is generally well tolerated in this population (Clinicaltrials.gov NCT01718938).
Determinants of IBD‐related disability: a cross‐sectional survey from the GETAID
Authors: Tannoury Jenny , Nachury Maria , Martins Carole , Serrero Melanie , Filippi Jerome , Roblin Xavier , Bourrier Anne , Bouguen Guillaume , Franchimont Denis , Savoye Guillaume , Buisson Anthony , Louis Edouard , Nancey Stephane , Abitbol Vered , Reimund Jean‐Marie , DeWitt Olivier , Vuitton Lucine , Mathieu Nicolas , Peyrin‐Biroulet Laurent , Gilletta Cyrielle , Allez Matthieu , Viennot Stephanie , Trang‐Poisson Caroline , Laharie David , Amiot Aurelien ,   the GETAID‐Patient Experience Study Group
Published: September 2023

Background

The burden of inflammatory bowel disease (IBD) is rising worldwide. The goal of IBD treatment is to achieve clinical and endoscopic remission but also prevent disability.

Aims

To identify the predictive factors of disability in a large population of patients with IBD.

Patients and methods

We conducted a cross‐sectional survey in 42 tertiary centres in France and Belgium. A self‐administered questionnaire was designed to explore patients and their IBD characteristics. IBD‐disk is a validated tool to measure disability in patients with IBD. The IBD‐disk score was then calculated for each patient. Based on a previous study, an overall IBD‐disk score ≥40 was associated with moderate‐to‐severe disability.

Results

Among the 2011 patients, 1700 were analysed, including 746 (44%) in self‐reported clinical remission and 752 (44.2%) declaring clinical activity. The patient global assessment of global remission was missing in 200 (11.8%) of 1700 patients. Moderate‐to‐severe disability was significantly increased in patients with BMI >25 kg/m2 (OR = 1.66; 95% CI [1.29‐2.14]), in those having perception of need for a psychotherapist (OR = 2.24; 95% CI [1.79‐3.05]) and social worker (OR = 1.54; 95% CI [1.08‐2.21]). Conversely, male gender (OR = 0.83; 95% CI [0.69‐0.99]), ulcerative colitis (OR = 0.69; 95% CI [0.53‐0.92]), self‐reported clinical remission (OR = 0.59; 95% CI [0.46‐0.77]) and employed or student occupational status (OR = 0.69; 95% CI [0.52‐0.92]) were inversely correlated with disability. Overall, 257 (34.5%) patients who declared being in clinical remission had disability.

Conclusion

Determinants of IBD‐related disability include IBD‐related factors but also psychological and social factors. This highlights the importance of a multidisciplinary team in the management of patients with IBD.
Trends in paediatric inflammatory bowel disease‐attributable direct costs: a population‐based analysis
Authors: El‐Matary Wael , Nugent Zoann , Witt Julia , Bernstein Charles N.
Published: September 2023

Background

In addition to its morbidities, inflammatory bowel disease (IBD) has a major financial burden on patients and healthcare systems. However, there is a paucity of evidence on IBD‐attributable costs in children.

Aims

To determine the trends of IBD‐attributable direct costs over time using a population‐based analysis.

Methods

Data were extracted from Manitoba Health Provider Claims and other population registry datasets from 1995 to 2017. Children with IBD were matched by age, sex and location with children without IBD. IBD‐attributable direct costs were calculated using utilization counts from the administrative data and cost estimates from different sources. Inpatient hospitalisation and outpatient procedure costs were estimated using the resource intensity weight (RIW) that is attached to each record in the data. Costs were expressed in Canadian dollars.

Results

We included 733 (428 with Crohn's disease) prevalent cases who were diagnosed with IBD before the age of 18 years and were followed for 2450 person‐years. A matched control group of 6763 persons who were followed for 21 558 person‐years was included. The median annual costs of physician services billed per patient increased from $381 (IQR 215‐1064) in 1995 to $936 (IQR 579‐1932) in 2017 (P < 0.001). The annual medication costs per patient increased from a median of $270 in 1995 to $7944 in 2017 (P < 0.0001). The median annual direct cost per patient was $1810 in 2004 as compared to $14 791 (P < 0.0001) in 2017.

Conclusions

Over two decades, there was a significant increase in the paediatric IBD‐attributable direct costs mainly driven by medication costs.
Innovation approaches and innovation logics: An empirical study on developing entertaining digital games
Authors: Wikhamn Björn Remneland , Styhre Alexander
Published: September 2023

This paper sets out to analyse how game developers create entertaining digital games and, more precisely, what forms of innovation approaches they adopt and why. Based on an empirical study of Swedish game development studios, we conceptualize two different approaches to innovation: a more inward‐oriented and developer‐centric (i.e., closed) approach and a more outward‐oriented and user‐centric (i.e., open) approach. Given that the firms in this study are acting under similar contingencies while adopting very different innovation approaches, we introduce innovation logics as a theoretical concept to understand how founders and managers justify their choice of approach (i.e., open vs. closed). Inspired by the ‘orders of worth’ framework by Boltanski and Thévenot, we highlight two distinctive innovation logics—that is, a creative logic versus an iterative logic—that the interviewees draw on. This paper contributes to the open innovation literature by highlighting two forms of innovation approaches and explaining how and why they differ in terms of ‘openness’ in relation to the surrounding ecosystem.
One‐piece versus two‐piece zirconia abutment supported single implant crown in the esthetic region: 3‐Year results from a split‐mouth randomized controlled clinical trial
Authors: Lv Xiaolei , Pu Yiping , Zhang Xiaomeng , Jiang Xue , Zhang Xiao , Shi Junyu , Lai Hongchang
Published: September 2023

Objectives

To compare the clinical, radiographic, and immunological outcomes between one‐piece versus two‐piece zirconia abutments supported single implant crowns in the esthetic region.

Materials and Methods

The study followed a split‐mouth, double‐blind, and randomized controlled clinical design for a duration of 3 years. Twenty‐two eligible patients with 44 implants were randomly assigned to two groups: Group 1 (one‐piece zirconia abutment with zirconia base, n = 22) and Group 2 (two‐piece zirconia abutment with titanium base, n = 22). The primary outcome was the technical complication rate. Additionally, survival rates, cytokines concentrations in peri‐implant crevicular fluid (PICF), peri‐implant conditions, marginal bone loss, and pink/white esthetics score (PES/WES) were assessed as secondary outcomes.

Results

Twelve of 22 patients attended the 1‐year follow‐up (due to the COVID pandemic), and 19 patients attended the 3‐year examination. Two abutments in Group 1 were fractured after 10 and 12 months in function. Additionally, one screw loosening occurred in Group 1 at 1‐year follow‐up. The 3‐year technical complication rate was significantly higher in Group 1 than that in Group 2 (15.79% vs. 0%, p < .001). The 3‐year implant survival rate was 100% in both groups. The concentration of IFN‐γ in PICF was significantly upregulated in Group 2 (p = .018). Furthermore, the IL‐6 concentration was positively correlated with BOP% (p = .020).

Conclusions

Two‐piece zirconia abutments exhibited superior technical performance compared to one‐piece designs during a 3‐year follow‐up in the anterior region. However, further long‐term research is necessary to verify the immunological stability of two‐piece zirconia abutments.
Cigarette smoke uptake by different woven fabrics: Analysis of mechanical and colour properties
Authors: Kayar Mahmut , Boztoprak Yalçin , Nallbani Belma Gjergjizi
Published: September 2023

Although the impact of smoking tobacco on human health is well understood, less is known about the effects of tobacco smoke on cotton, viscose and polyamide fabrics. In this study, tobacco smoke was applied to fabric samples to investigate the effects of tobacco smoke on their mechanical and colour properties. For this purpose, tobacco smoke was pumped into a mechanism consisting of a glass box, in which cotton, viscose and polyamide fabrics were placed in a suspended position. The fabric samples were treated with tobacco smoke for 1 or 2 months. The samples were evaluated in terms of tensile and tear strength, elongation at break, as well as pilling and abrasion resistance values. A colour measurement test was used to investigate the withering effect of tobacco smoke, and Fourier Transfer–Infrared analysis was performed to examine the chemical changes. The tensile strength values in the warp direction were 419.34, 404.62 and 421.78 N without treatment and after 1 and 2 months of tobacco smoke treatment, respectively, for the cotton woven fabric. Furthermore, for woven cotton fabric, the L* value decreased from 93.8 to 78.7 after being treated with tobacco smoke for 2 months. As a result of this study, it was determined that tobacco smoke has no effect on the tensile strength properties of fabrics, causes changes to pilling and abrasion resistance values, and adversely affects the colour properties of fabrics.
Atrial fibrillation as a risk factor for exercise‐induced pulmonary haemorrhage following a standardised exercise test
Authors: Hansen Sanni , Otten Nina D. , Nissen Sarah D. , Carstensen Helena , Hopster‐Iversen Charlotte , Fjeldborg Julie , Staun Sophie H. , Fenner Merle , Hesselkilde Eva M. , Buhl Rikke
Published: September 2023

Background

Atrial fibrillation (AF) has been proposed as a risk factor for exercise‐induced pulmonary haemorrhage (EIPH) due to increased pressure in the left atrium.

Objective

To evaluate if AF was associated with EIPH following a standardised exercise test (SET) to fatigue.

Study design

Two‐arm controlled experiment.

Methods

Ten untrained Standardbred mares mean (standard deviation [SD]) age 6 (2) years performed a SET on the treadmill in sinus rhythm (SR) (SET1) and 25–44 days after induction of self‐sustained AF (SET2). AF was induced by tachypacing using a pacing device. Endoscopy, including tracheal wash and bronchoalveolar lavage (BAL), was performed 48–72 h before and 24 h after the two SETs. In addition, endoscopic grading of tracheal blood was performed 2 h after each SET.

Results

After SET1, none of the horses showed blood in the trachea, and two horses showed erythrophagocytosis. Following SET2, two horses had grade 1 blood in the trachea and free erythrocytes and erythrophagocytosis in the BAL, while another two horses had erythrophagocytosis in the BAL. In SET2, the overall performance on the treadmill was decreased with a lower maximum velocity (SET1 10.3 ± 0.8 m/s vs. SET2 8.9 ± 0.9 m/s, p = 0.004), a higher heart rate (284 ± 21 vs. 221 ± 18 bpm, p = 0.003) and more abnormal QRS complexes (p < 0.001) compared with SET1.

Conclusions

Two horses showed signs of EIPH, resulting in visible blood in the trachea, when exercising in AF compared with SR. However, a possible link between EIPH, pulmonary pressure and AF needs to be further elucidated.
The admissibility and persuasiveness of expert evidence
Authors: Altobelli Thomas , Smith Bruce Gordon
Published: September 2023

Parenting plan evaluators are expert witnesses who offer their opinion. Courts in common law jurisdictions generally do not accept evidence of an opinion as it is not considered to be reliable evidence from which to establish a fact. An exception to that general principle is expert opinion evidence. In short, an opinion from a person with specialized knowledge or expertise about the area in which they are an expert may be sufficiently reliable to form an evidentiary basis from which to make a finding of fact, provided the opinion meets certain criteria. These criteria will be discussed in this article, as well as what is relevant, reliable and persuasive evidence. The relevant legal principles will be examined in an historical and contemporary, theoretical and practical context. The authors reflect on their considerable experience as consumers of expert evidence and apply this to parenting plan evaluations, as well as considering future challenges in the field.
Analysis of a nursing survey: Reasons for compromised quality of care in inpatient mental health wards
Authors: Thompson Elissa , Senek Michela , Ryan Tony
Published: September 2023

Current evidence suggests understaffing is related to poor quality and missed care in a global context, but this relationship is complex. There is also a research gap for quality in mental health care in the United Kingdom that includes a wider set of patient outcomes. This paper aims to investigate RMN's perception of quality of care on their last shift, their self‐reported reasons for compromised care and potential impact on patient outcomes. A mixed methods approach, we used descriptive statistics to create a framework within which to qualitatively analyse data from the 2017 Royal College of Nursing (RCN) employment survey to consider the complex relationship between understaffing and care quality. We established three themes: ‘Understaffing’, ‘Professional Code Expectations and Moral Distress’ and ‘Management’. In line with the current evidence; lack of resources and understaffing were consistently present throughout. Nurses also felt pressure from the Nursing and Midwifery Council (NMC) code of conduct which in turn instilled shame and fear for their registration when they were unable to achieve the standards expected. This was further exacerbated by poor management and supervision; leading nurses to reflect on poor outcomes for patients which compromised not only legal rights but safety of patients and staff alike. We conclude that focusing on staffing numbers alone is unlikely to improve care quality.
Athletes and suspected catecholaminergic polymorphic ventricular tachycardia: Awareness and current knowledge
Authors: Mascia Giuseppe , Brugada Josep , Arbelo Elena , Porto Italo
Published: September 2023

Introduction

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a cardiac inherited arrhythmogenic disease potentially leading to sudden cardiac death that is determined by electrical instability exacerbated by acute adrenergic tone.

Methods and Results

Despite its life‐threatening nature, CPVT remains potentially unnoticed since diagnosis may be difficult especially in apparently healthy athletes. This review summarizes current knowledge and shortcomings of CPVT, focusing on genetics, arrhythmic mechanisms, sport preparticipation screening, and current recommendations.

Conclusions

The paper captures the importance of CPVT athletes regarding the necessity of risk stratification, as well as the importance of maintaining a healthy lifestyle.
Catheter‐induced right bundle branch block: Practical implications for the cardiac electrophysiologist
Authors: Ali Hussam , Lupo Pierpaolo , Foresti Sara , De Ambroggi Guido , Anderson Robert H. , De Lucia Carmine , Turturiello Dario , Paganini Edoardo Maria , Bessi Riccardo , Contrafatto Igino , Farghaly Ahmad Abdelrady Abdelsalam , Cristiano Ernesto , Cappato Riccardo
Published: September 2023

The right bundle branch (RBB), due to its endocardial course, is susceptible to traumatic block caused by “bumping” during right‐heart catheterization. In the era of cardiac electrophysiology, catheter‐induced RBB block (CI‐RBBB) has become a common phenomenon observed during electrophysiological studies and catheter ablation procedures. While typically transient, it may persist for the entire procedure time. Compared to pre‐existing RBBB, the transient nature of CI‐RBBB allows for comparative analysis relative to the baseline rhythm. Furthermore, unlike functional RBBB, it occurs at similar heart rates, making the comparison of conduction intervals more reliable. While CI‐RBBB can provide valuable diagnostic information in various conditions, it is often overlooked by cardiac electrophysiologists. Though it is usually a benign and self‐limiting conduction defect, it may occasionally lead to diagnostic difficulties, pitfalls, or undesired consequences. Avoidance of CI‐RBBB is advised in the presence of baseline complete left bundle branch block and when approaching arrhythmic substrates linked to the right His‐Purkinje‐System, such as fasciculo‐ventricular pathways, bundle branch reentry, and right‐Purkinje focal ventricular arrhythmias. This article aims to provide a comprehensive practical review of the electrophysiological phenomena related to CI‐RBBB and its impact on the intrinsic conduction system and various arrhythmic substrates.