bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemotherapy in Well Differentiated Neuroendocrine Tumors (NET) G1, G2, and G3: A Narrative Review
Authors: Zappi Arianna , Persano Irene , Galvani Linda , Parlagreco Elena , Andrini Elisa , Campana Davide , Brizzi Maria Pia , Lamberti Giuseppe , La Salvia Anna
Published: January 2023

Neuroendocrine tumors (NETs) are rare neoplasms with a wide spectrum of clinical behavior, from the long survival of well-differentiated NETs to the dismal prognosis of high-grade neuroendocrine carcinomas (NECs), being G3 NETs a recently recognized intermediate entity. While the role of chemotherapy is well established in NECs, data on NETs mostly derives from small studies, experts’ opinions, and extrapolating results from small-cell lung cancer studies. This narrative review aims to summarize available evidence about the use of chemotherapy in the setting of G1-2 NETs and G3 NETs. We performed literature research in PubMed Library for all articles published up to September 2022 about the efficacy of chemotherapy in NETs. Treatment regimens with STZ-5FU, CAPTEM, and anti-metabolite-based treatment are the most active and tolerated in gastroenteropancreatic NETs (GEP-NETs) G1-G2, while platinum-based regimens (FOLFOX/XELOX) and TEM/CAPTEM showed the best activity in thoracic NETs. Solid evidence about chemotherapy efficacy in G3 NETs is still lacking. Literature data support the use of chemotherapy in low-intermediate grade NETs after the failure of other therapies or if tumor shrinkage is needed. Studies assessing G3 NETs independently from NECs are needed to better understand the role of chemotherapy in this setting.
Advance of Thrombolysis and Thrombectomy in Acute Ischemic Stroke
Authors: Nam Hyo Suk , Kim Byung Moon
Published: January 2023

Globally, stroke remains the second leading cause of death, and the third-leading cause of death and disability, in the world [...]
Comparison of Transperitoneal and Retroperitoneal Robotic Partial Nephrectomy for Patients with Completely Lower Pole Renal Tumors
Authors: Zhao Wenlei , Ding Yancai , Chen Dong , Xuan Yundong , Chen Zhiqiang , Zhao Xupeng , Jiang Bin , Wang Baojun , Li Hongzhao , Yin Chengliang , Ma Xin , Guo Gang , Gu Liangyou , Zhang Xu
Published: January 2023

(1) Background: For completely lower pole renal tumors, we compared the perioperative outcomes of robotic partial nephrectomy via transperitoneal and retroperitoneal approaches. (2) Methods: Complete lower pole renal tumors were defined as tumors that received 1 point for the “L” element of the R.E.N.A.L. and located at the lower pole of kidney. After confirming consistency in baseline characteristics, oncological and functional benefits were compared. Pentafecta achievement was used to represent the perioperative optimal outcome, followed by multivariate analysis of factors associated with the lack of pentafecta achievement. (3) Results: Among 151 patients identified, 116 (77%) underwent robotic partial nephrectomy via a transperitoneal approach and 35 (23%) via a retroperitoneal approach. Patients undergoing transperitoneal robotic partial nephrectomy experienced more blood loss than those undergoing retroperitoneal robotic partial nephrectomy (50 mL vs. 40 mL, p = 0.015). No significant differences were identified for operative time (120 min vs. 120 min), ischemia time (19 min vs. 20 min), positive surgical margins (0.0% vs. 2.86%), postoperative rate of complication (12.07% vs. 5.71%). No significant differences were identified in pathologic variables, eGFR decline in postoperative 12-month (3.9% vs. 5.4%) functional follow-up. Multivariate cox analysis showed that tumor size (OR: 0.523; 95% CI: 0.371–0.736; p < 0.001) alone was independently correlated to the achievement of pentafecta. (4) Conclusions: For completely lower pole renal tumors, transperitoneal and retroperitoneal robotic partial nephrectomy provide similar outcomes. These two surgical approaches remain feasible options for these cases.
The Value of the First Clinical Impression as Assessed by 18 Observations in Patients Presenting to the Emergency Department
Authors: Tschoellitsch Thomas , Krummenacker Stefan , Dünser Martin W. , Stöger Roland , Meier Jens
Published: January 2023

The first clinical impression of emergency patients conveys a myriad of information that has been incompletely elucidated. In this prospective, observational study, the value of the first clinical impression, assessed by 18 observations, to predict the need for timely medical attention, the need for hospital admission, and in-hospital mortality in 1506 adult patients presenting to the triage desk of an emergency department was determined. Machine learning models were used for statistical analysis. The first clinical impression could predict the need for timely medical attention [area under the receiver operating characteristic curve (AUC ROC), 0.73; p = 0.01] and hospital admission (AUC ROC, 0.8; p = 0.004), but not in-hospital mortality (AUC ROC, 0.72; p = 0.13). The five most important features informing the prediction models were age, ability to walk, admission by emergency medical services, lying on a stretcher, breathing pattern, and bringing a suitcase. The inability to walk at triage presentation was highly predictive of both the need for timely medical attention (p < 0.001) and the need for hospital admission (p < 0.001). In conclusion, the first clinical impression of emergency patients presenting to the triage desk can predict the need for timely medical attention and hospital admission. Important components of the first clinical impression were identified.
Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over
Authors: Han Yingdong , Wang Shuolin , Zhao He , Cao Yu , Han Xinxin , Di Hong , Yin Yue , Wu Juan , Zhang Yun , Zeng Xuejun
Published: January 2023

Previous studies have generally reported the association between serum uric acid (SUA) and diabetic complications, but large-scale research exploring the above association in U.S. adults with diabetes is limited. To explore the association between SUA and chronic complications of diabetes among U.S. patients aged ≥40, we used data from the National Health and Nutrition Examination Survey 1999–2008. SUA was divided into three levels: T1 (SUA ≥ 420 μmol/L), T2 (300 ≤ SUA < 420 μmol/L), and T3 (SUA < 300 μmol/L). Binary logistic regression and restricted cubic spline analysis were applied to evaluate the association between SUA and chronic complications of diabetes. A trend test was performed as the SUA increased substantially. After full-adjusted confounding factors, patients in the T3 group had a lower risk of diabetic kidney disease, cardiovascular disease, and peripheral neuropathy compared with the T1 group, with a OR (95% CIs) of 0.33 (0.21–0.52), 0.56 (0.36–0.87), and 0.49 (0.27–0.89), respectively. The restricted cubic spline showed a significant positive relationship between SUA and cardiovascular disease and diabetic kidney disease in diabetes patients, but not peripheral neuropathy. Maintaining a SUA of less than 300 μmol/L might be protective against the risk of cardiovascular disease, diabetic kidney disease, and peripheral neuropathy other than diabetic retinopathy compared with a SUA of more than 420 μmol/L in U.S. diabetes patients aged 40 and over.
Kinetic and Kinematic Analysis of Landing during Standing Back Somersault Using Three Technical Arm Swings in Artistic Gymnastics
Authors: Mkaouer Bessem , Akkari-Ghazouani Hounaida , Amara Samiha , Bouguezzi Raja , Jemni Monèm , Chaabene Helmi
Published: January 2023

The crucial criteria when assessing technical performance in artistic gymnastics is the higher elevation of the gymnast’s body and a stable landing (i.e., stick-landing). The purpose of this study was to compare kinetic and kinematic parameters during the landing phase of standing back somersaults (SBS) following three technical arm-swing performed during the preparatory phase in high-level male gymnasts. The three different arm-swing pertain to three “gymnastics schools”, i.e., Russian, Chinese, and Romanian. Six high-level male gymnasts participated in this study. Three arm-swing with different angles (i.e., SBS270°, SBS180°, and SBS90°) were randomly performed. A 3D kinetic and kinematic analysis was conducted. Results showed significant variation in the landing angle (p = 0.009) across the three arm-swing techniques. The SBS90° arm-swing resulted in the closest angle to the vertical. Additionally, the SBS90° arm-swing technique induced the lowest horizontal and vertical force values upon landing compared to the other arm-swing techniques (SBS270°: p = 0.023 and 0.009, respectively; SBS180°: p = 0.004 and 0.080, respectively). The same was noted for the horizontal velocity (p = 0.021) with the lowest values noted for the SBS90° arm-swing technique. However, the best opening angle was observed during the SBS270° technique, since it presented the best vertical displacement. In conclusion, the SBS with a SBS90° arm-swing seems to favor a better absorption of the ground reaction force upon landing by reducing the intensity of the impact with the ground and by affording a landing angle closer to the vertical in high-level male gymnasts.
A Positive Association between Working Memory Capacity and Human Creativity: A Meta-Analytic Evidence
Authors: Gong Zheng , Miao Kuan , Liu Xuerong , Luo Mengjie , Yu Yang , Chen Zhiyi
Published: January 2023

Creativity serves as a fountain for social and scientific development. As one of the most crucial human capabilities, creativity has been believed to be supported by the core component of higher cognitive functions—working memory capacity (WMC). However, the evidence supporting the association between WMC and creativity remains contradictory. Here, we conducted a meta-analysis using random-effects models to investigate the linear association between WMC and creativity by pooling the individual effect size from the previous literature. Further, a subgroup analysis was performed to examine whether such association is specific for different WMC categories (i.e., verbal WMC, visual–spatial WMC and dual-task WMC). The main meta-analytic results showed a significantly positive association between WMC and creativity (r = .083, 95% CI: .050–.115, p < .001, n = 3104, k = 28). The subgroup analysis demonstrated consistent results by showing a significantly positive association between them, irrespective of WMC category. We also found that cultural environments could moderate this association, and we identified a strong correlation in participants from an Asian cultural context. In conclusion, this study provides the evidence to clarify the positive association between WMC and creativity, and implies that the Asian cultural context may boost such an association.
Effect of Rigid Vegetation Arrangement on the Mixed Layer of Curved Channel Flow
Authors: Huang Tianwei , He Mengxing , Hong Kan , Lin Yingtien , Jiao Pengcheng
Published: January 2023

Curved channels and aquatic vegetation are commonly present in the riverine environment. In this study, the effects of vegetation density and distribution on the hydrodynamic characteristics of a mixed layer developed over a 180-degree curved channel were investigated through flume experiments. Wooden sticks were used to simulate rigid vegetation distributed along the half side of the channel, and a 200 Hz acoustic Doppler velocimeter (ADV) was employed to measure the three-dimensional instantaneous velocity at five selected cross sections along the curved channel. Experimental results show that the vegetation covering the half of the channel significantly affects the hydrodynamic structure of the curved channel flow, and the unequal vegetation resistance induces the K-H instability at the vegetation and non-vegetation interface, resulting in a standard hyperbolic tangent function of streamwise velocity distribution along the lateral direction. The influence of curve position on turbulence kinetic energy is far greater than that of vegetation density and vegetation distribution. The peak value of turbulent kinetic energy is comprehensively affected by vegetation density and distribution, and the peak position of turbulent kinetic energy at the interface is changed by different vegetation distribution. The combined effect of the curve and the partly covered vegetation increases the mixing between the water bodies, enhancing turbulent kinetic energy, and vegetation along the concave bank plays a more significant role. For turbulent bursting, the inward and outward interactions are mainly bursting events in the vegetation area, while ejections and sweeps are dominant in the non-vegetation area. However, the critical vegetation condition to initiate large-scale coherent structure (LSS) in the mixed layer and the influence of flexible vegetation need to be further studied in the future.
Experimental Study of the Dynamic Shear Modulus of Saturated Coral Sand under Complex Consolidation Conditions
Authors: Ma Weijia , Qin You , Gao Fei , Wu Qi
Published: January 2023

The shear modulus is an essential parameter that reflects the mechanical properties of the soil. However, little is known about the shear modulus of coral sand, especially under complex consolidation conditions. In this paper, we present the results of a multi-stage strain-controlled undrained cyclic shear test on saturated coral sand. The influences of several consolidation state parameters: effective mean principal stress (p0′), consolidation ratio (kc), consolidation direction angle (α0), and coefficient of intermediate principal stress (b) on the maximum shear modulus (G0), the reference shear strain (γr) and the reduction of shear modulus (G) have been investigated. For a specified shear strain level, G will increase with increasing p0′ and kc, but decrease with increasing α0 and b. However, the difference between G for various α0 and b can be reduced by the increase of shear strain amplitude (γa). G0 shows an increasing trend with the increase of p0′ and kc; on the contrary, with the increase of α0 and b, G0 shows a decreasing trend. To quantify the effect of consolidation state parameters on G0, a new index (μG0) with four parameters (λ1, λ2, λ3, λ4) which is related to p0′, kc, α0, b is proposed to modify the prediction model of G0 in literature. Similarly, the values of γr under different consolidation conditions are also evaluated comprehensively by the four parameters, and the related index (μγr) is used to predict γr for various consolidation state parameters. A new finding is that there is an identical relationship between normalized shear modulus G/G0 and normalized shear strain γa/γr for various consolidation state parameters and the Davidenkov model can describe the G/G0–γa/γr curves. By using the prediction model proposed in this paper, an excellent prediction of G can be obtained and the deviation between measured and predicted G is all within ±10%.
Trajectory Data Compression Algorithm Based on Ship Navigation State and Acceleration Variation
Authors: Gao Junbo , Cai Ze , Yu Wangjing , Sun Wei
Published: January 2023

An active area of study under the dual carbon target, which is based on automatic identification systems (AIS), is the emission inventory of pollutants from ships. Data compression is required because there is currently so much data that it has become difficult to transmit, process, and store it. A trajectory simplification method considering the ship sailing state and acceleration rate of change is developed in this paper to assure the validity of the compressed data used in the emission inventory analysis. By carefully examining the integral relationship between acceleration and pollution emissions, the algorithm constructs an acceleration rate of change function for data compression and categorizes AIS data by ship navigation status. By dynamically altering the amount of acceleration change, the developed function can stabilize the pollutant emission calculation error and adaptively calculate the threshold value. The experimental results show that the emission calculation error of the proposed algorithm is only 0.185% when the compression rate is 90.28%.
Causality of Risk Assessment Attributes under Uncertainty in Taiwan’s Offshore Wind Farms Development
Authors: Tsai Feng-Ming , Kao Sheng-Long , Sujanto Raditia Yudistira , Tseng Ming-Lang , Hsu Tai-Wen , Chou Chien-Chang
Published: January 2023

This study contributes to investigating the causality of risk assessment attributes under uncertainty for the offshore wind farms development in Taiwan. The investigation of risk assessment attributes for the offshore wind farms development has increasingly attracted more notice as multifaceted challenges from socioeconomic, safety, and environmental perspectives emerged. Yet, the literature is lacking a multi-perspective viewpoint of the determining attributes and an examination of the attributes’ interrelationships using qualitative information. To fill this gap, this study aims to identify the valid attributes based on the multi-perspectives of feasibility, environment, economic, and safety risks, and investigate the attributes’ interrelationships. Thus, this study employs the fuzzy Delphi method to obtain valid risk assessment attributes and adopts a fuzzy decision-making trial and evaluation laboratory method to examine the attributes’ interrelationships while identifying the multi-perspective-based crucial attributes. The results indicate that human safety, impact on marine environment, and navigation safety are crucial risk aspects to be assessed. From the practical point of view, this study found that safety of ship crews and passengers, safety of maintenance crews, local fishery industry, public trust in environmental regulations, and change of income for fishermen are the important risk criteria to be prioritized when developing offshore wind farms.
Seismic Multiple Attenuation in the Continent–Ocean Transition Zone of the Northern South China Sea
Authors: Chen Nan , Li Chun-Feng , Wen Yong-Lin , Wang Peng , Zhao Xiu-Lian , Wan Xiao-Li
Published: January 2023

In this study, we process four new multichannel reflection seismic profiles acquired in 2015 and 2016 in the continent–ocean transition zone (COT) of the northern South China Sea (SCS). We apply a multi-domain, progressive, and seabed-controlled denoising technique and obtain a good denoising effect. Combining velocity analysis in the multi-round time domain and forward modeling, we analyze the types and characteristics of multiples in the study area and formulate an effective demultiple technique to attenuate strong seabed multiples, diffracted multiples from rough seafloor, and other multiples from deep reflectors. The processing results show that the sea surface-related multiple elimination technique predicts the sea surface-related multiples accurately by data convolution, and has a good effect in attenuating seabed multiples. Diffracted multiple attenuation method extracts high-frequency and high-energy diffracted multiples, and suppresses multiples by the energy ratios of multiples to primary events. To attenuate deep multiples, we select predictive deconvolution to attenuate periodic deep multiples after many trials and detailed analysis. The combination of these different techniques in sequence proves to be quite effective in attenuating different seismic multiples in the COT. The imaged crustal structures near the COT often show strong magmatism and/or basement uplifting. The faulted and thinned continental crust adjacent to the COT corresponds to the lowest free-air gravity anomalies. Gravity anomalies often increase from the COT to the oceanic crust. An exception is to the northeast of the SCS, where the relatively wide COT shows very high gravity anomalies, likely induced by mantle upwelling and serpentinization.
Experimental Investigation into the Erosion Performance of Water Jets on Marine Hydrate-Bearing Sediment
Authors: Pan Dongbin , Yang Lin , Chen Chen , Li Xitong
Published: January 2023

Fine-grained natural gas hydrate (NGH) reservoirs are widely distributed across the world and bear more than 90% of global NGH. However, it is difficult to exploit this kind of NGH reservoir economically and environmentally using conventional methods. Water-jet cutting is an efficient and environmentally friendly technique for mining such hydrate reservoirs, as the production process does not depend on mass and heat transfer within the formations. In this work, a series of physical experiments were conducted to clarify the erosion performance of marine hydrate-bearing sediment (HBS) impacted by water jets. The results show that the accumulation of sediment particles and hydrate particles at the bottom of erosion hole severely inhibits the vertical erosion of HBS by water jet. For a particular jet flow rate, the jet distance has an optimal value, which is between 4 mm and 28 mm. Moreover, the upwelling flow containing solid particles has a significant impact on the erosion of the hole top. In reservoirs with a low hydrate saturation (20–40%) and reservoirs with a high hydrate saturation (60–80%), the erosion holes exhibit a gourd shape and a bamboo shape, respectively. In addition, the volume erosion efficiency and the depth erosion efficiency are more sensitive to the variation in jet flow rate than jet distance and hydrate saturation. This study can provide theoretical and technical support for the application of water-jet cutting in the exploitation of marine HBS.
Putative Core Transcription Factors Affecting Virulence in Aspergillus flavus during Infection of Maize
Authors: Gilbert Matthew K. , Mack Brian M. , Lebar Matthew D. , Chang Perng-Kuang , Gross Stephanie R. , Sweany Rebecca R. , Cary Jeffrey W. , Rajasekaran Kanniah
Published: January 2023

Aspergillus flavus is an opportunistic pathogen responsible for millions of dollars in crop losses annually and negative health impacts on crop consumers globally. A. flavus strains have the potential to produce aflatoxin and other toxic secondary metabolites, which often increase during plant colonization. To mitigate the impacts of this international issue, we employ a range of strategies to directly impact fungal physiology, growth and development, thus requiring knowledge on the underlying molecular mechanisms driving these processes. Here we utilize RNA-sequencing data that are obtained from in situ assays, whereby Zea mays kernels are inoculated with A. flavus strains, to select transcription factors putatively driving virulence-related gene networks. We demonstrate, through growth, sporulation, oxidative stress-response and aflatoxin/CPA analysis, that three A. flavus strains with knockout mutations for the putative transcription factors AFLA_089270, AFLA_112760, and AFLA_031450 demonstrate characteristics such as reduced growth capacity and decreased aflatoxin/CPA accumulation in kernels consistent with decreased fungal pathogenicity. Furthermore, AFLA_089270, also known as HacA, eliminates CPA production and impacts the fungus’s capacity to respond to highly oxidative conditions, indicating an impact on plant colonization. Taken together, these data provide a sound foundation for elucidating the downstream molecular pathways potentially contributing to fungal virulence.
More than Just Protein Degradation: The Regulatory Roles and Moonlighting Functions of Extracellular Proteases Produced by Fungi Pathogenic for Humans
Authors: Satala Dorota , Bras Grazyna , Kozik Andrzej , Rapala-Kozik Maria , Karkowska-Kuleta Justyna
Published: January 2023

Extracellular proteases belong to the main virulence factors of pathogenic fungi. Their proteolytic activities plays a crucial role in the acquisition of nutrients from the external environment, destroying host barriers and defenses, and disrupting homeostasis in the human body, e.g., by affecting the functions of plasma proteolytic cascades, and playing sophisticated regulatory roles in various processes. Interestingly, some proteases belong to the group of moonlighting proteins, i.e., they have additional functions that contribute to successful host colonization and infection development, but they are not directly related to proteolysis. In this review, we describe examples of such multitasking of extracellular proteases that have been reported for medically important pathogenic fungi of the Candida, Aspergillus, Penicillium, Cryptococcus, Rhizopus, and Pneumocystis genera, as well as dermatophytes and selected endemic species. Additional functions of proteinases include supporting binding to host proteins, and adhesion to host cells. They also mediate self-aggregation and biofilm formation. In addition, fungal proteases affect the host immune cells and allergenicity, understood as the ability to stimulate a non-standard immune response. Finally, they play a role in the proper maintenance of cellular homeostasis. Knowledge about the multifunctionality of proteases, in addition to their canonical roles, greatly contributes to an understanding of the mechanisms of fungal pathogenicity.
Sublethal Effects of Beauveria bassiana Strain BEdy1 on the Development and Reproduction of the White-Backed Planthopper, Sogatella furcifera (Horváth) (Hemiptera: Delphacidae)
Authors: Xia Yongbo , Yu Siyuan , Yang Qunfang , Shang Jing , He Yi , Song Fuyun , Li Qing , Jiang Chunxian
Published: January 2023

Rice (Oryza sativa) is the most important food crop all over the world, while white-backed planthopper (WBPH), Sogatella furcifera (Horváth) (Hemiptera: Delphacidae) is an important pest causing rice yield reduction. The purpose of this study is to evaluate the sublethal effects of strain BEdy1 Beauveria bassiana (Bals.-Criv.) Vuill. (Hypocreales: Cordycipitaceae) on S. furcifera using the two-sex life table analytical method, compare the life tables of the F0 and F1 generations of WBPHs which were treated with sublethal concentrations (LC10, LC25) of B. bassiana BEdy1 with a control group. The results showed that the duration of the egg, 4th-instar and 5th-instar nymph, pre-adult, total pre-oviposition (TPOP) and mean generation time (T) for the LC25 treatment were significantly longer than those of the control and LC10 treatment. However, the duration of the adult, the longevity of male and female adults and the oviposition days of female adults for the LC25 treatment were significantly shortened. The fecundity of female adults, intrinsic rate of increase (r), net reproductive rate (R0) and finite rate of increase (λ) for the LC25 treatment were significantly decreased compared with those of other treatments. The duration of the egg and pre-adult stage for the LC10 treatment were longer than those of the control group, but the population parameters showed no significant difference. Therefore, the LC25 of B. bassiana BEdy1 can inhibit the population growth of S. furcifera.
Fungal Pathogens Associated with Crown and Root Rot in Wheat-Growing Areas of Northern Kyrgyzstan
Authors: Özer Göksel , Erper İsmail , Yıldız Şenol , Bozoğlu Tuğba , Zholdoshbekova Sezim , Alkan Mehtap , Tekin Fatih , Uulu Tair Esenali , İmren Mustafa , Dababat Abdelfattah A. , Derviş Sibel
Published: January 2023

Fungal species associated with crown and root rot diseases in wheat have been extensively studied in many parts of the world. However, no reports on the relative importance and distribution of pathogens associated with wheat crown and root rot in Kyrgyzstan have been published. Hence, fungal species associated with wheat crown/root rot were surveyed in three main wheat production regions in northern Kyrgyzstan. Fungal species were isolated on 1/5 strength potato-dextrose agar amended with streptomycin (0.1 g/L) and chloramphenicol (0.05 g/L). A total of 598 fungal isolates from symptomatic tissues were identified using morphological features of the cultures and conidia, as well as sequence analysis of the nuclear ribosomal internal transcribed spacer (ITS) region, the translation elongation factor 1α (TEF1), and the RNA polymerase II beta subunit (RPB2) genes. The percentage of fields from which each fungus was isolated and their relative percentage isolation levels were determined. Bipolaris sorokiniana, the causal agent of common root rot, was the most prevalent pathogenic species isolated, being isolated from 86.67% of the fields surveyed at a frequency of isolation of 40.64%. Fusarium spp. accounted for 53.01% of all isolates and consisted of 12 different species. The most common Fusarium species identified was Fusarium acuminatum, which was isolated from 70% of the sites surveyed with an isolation frequency of 21.57%, followed by Fusarium culmorum, Fusarium nygamai, Fusarium oxysporum, and Fusarium equiseti, all of which had a field incidence of more than 23%. Inoculation tests with 44 isolates representing 17 species on the susceptible Triticum aestivum cv. Seri 82 revealed that Fusarium pseudograminearum and F. culmorum isolates were equally the most virulent pathogens. The widespread distribution of moderately virulent B. sorokiniana appears to be a serious threat to wheat culture, limiting yield and quality. With the exception of F. culmorum, the remaining Fusarium species did not pose a significant threat to wheat production in the surveyed areas because common species, such as F. acuminatum, F. nygamai, F. oxysporum, and F. equiseti, were non-pathogenic but infrequent species, such as Fusarium redolens, Fusarium algeriense, and F. pseudograminearum, were highly or moderately virulent. Curvularia inaequalis, which was found in three different fields, was mildly virulent. The remaining Fusarium species, Fusarium solani, Fusarium proliferatum, Fusarium burgessii, and Fusarium tricinctum, as well as Microdochium bolleyi, Microdochium nivale, and Macrophomina phaseolina, were non-pathogenic and considered to be secondary colonizers. The implications of these findings are discussed.
Sugammadex in Emergency Situations
Authors: Motamed Cyrus
Published: January 2023

Sugammadex may be required or used in multiple emergency situations. Moderate and high doses of this compound can be used inside and outside the operating room setting. In this communication, recent developments in the use of sugammadex for the immediate reversal of rocuronium-induced neuromuscular blockade were assessed. In emergency surgery and other clinical situations necessitating rapid sequence intubation, the tendency to use rocuronium followed by sugammadex instead of succinylcholine has been increasing. In other emergency situations such as anaphylactic shock caused by rocuronium or if intubation or ventilation is not possible, priority should be given to resuming ventilation maintaining hemodynamic stability, in accordance with the traditional guidelines. If necessary for the purpose of resuming ventilation, reversal of neuromuscular blockade should be done in a timely fashion.
Blood Loss Following Open Posterior Spinal Fusion in Fractures: Cannulated vs. Solid Pedicle Screws
Authors: Rajabifard Pedram , Cunningham John Edward , Johnson Michael A. , Bäcker Henrik Constantin , Turner Peter
Published: January 2023

We aim to delineate whether there is increased blood loss with the use of cannulated pedicle screws compared to solid pedicle screws in patients undergoing posterior spinal fusion. A single-centre retrospective case-control study was undertaken on patients undergoing PSF for spinal fractures. Cannulated screw fixation was compared with solid screw fixation. Intraoperative blood loss was estimated using pre and postoperative haemoglobin levels, recorded estimated blood loss and cell saver reports. Anticoagulation, blood product administration, operative time and number of levels fused were assessed. A total of 64 cases, 32 in each cohort, were included in the analysis. Overall mean haemoglobin reduction from pre- to post-operative was 2.82 ± 1.85 g/L per screw inserted in the cannulated group, compared to a haemoglobin decrease of 2.81 ± 1.521 g/L per screw inserted in the solid screw group (p = 0.971). Total estimated intraoperative blood loss was 616.3 + 355.4 mL in the cannulated group, compared to 713.6 + 473.5 mL in the solid screw group (p = 0.456). Patients with preoperative thrombocytopenia had a transfusion rate of 0.5 ± 0.71 units/patient compared to 0.04 ± 0.19 units/patient in patients with normal platelet levels (p < 0.005). The differences in blood loss observed between cannulated and solid pedicle screws are non-significant overall. The largest predictor for need of transfusion was pre-operative thrombocytopenia, regardless of the type of screw used.
Effects of Pedagogical Agents on Learners’ Knowledge Acquisition and Motivation in Digital Learning Environments
Authors: Zeitlhofer Ines , Zumbach Joerg , Aigner Verena
Published: January 2023

We assume that learners generate self-reference to a topic dealt with in class through motivational prompts of a pedagogical agent (PA). This assumption is based on self-determination theory and organismic integration theory. Consequently, learners are more motivated and achieve better learning results. We examined the influence of motivational prompts on learning success and motivation in a digital learning environment. Therefore, we implemented a PA within a web-based learning environment in order to scaffold learners’ autonomous motivation. In an experimental pre-post design (n = 60), learning success and motivation were analyzed comparing learning environments with and without PA/prompting. Results suggest that learners with a PA reach a higher level of knowledge than learners without a PA. There was no significant influence of motivational prompts on motivation itself. The limitations and conclusions of this study are discussed.
Prediction of Multi-Scale Socioeconomic Parameters from Long-Term Nighttime Lights Satellite Data Using Decision Tree Regression: A Case Study of Chongqing, China
Authors: Xu Tingting , Zong Yunting , Su Heng , Tian Aohua , Gao Jay , Wang Yurui , Su Ruiqi
Published: January 2023

The Defense Meteorological Satellite Program Operational Linescan System (DMSP/OLS) and the Suomi National Polar-Orbiting Partnership satellite’s Visible Infrared Imaging Radiometer Suite (NPP/VIIRS) nighttime light (NTL) data provide an adequate proxy for reflecting human and economic activities. In this paper, we first proposed a novel data processing framework to modify the sensor variation and fit the calibrated DMSP/OLS data and NPP/VIIRS data into one unique long-term, sequential, time-series nighttime-lights data at an accuracy higher than 0.950. Both the supersaturation and digital value range have been optimized through a machine learning based process. The calibrated NTL data were regressed against six socioeconomic factors at multi-scales using decision tree regression (DTR) analysis. For a fast-developing city in China—Chongqing, the DTR provides a reliable regression model over 0.8 (R2), as well explains the variation of factor importance. With the multi-scaled analysis, we matched the long-term time-series NTL indices with appropriate study scale to find out that the city and sub-city region are best studied using NTL mean and stander derivation, while NTL sum and standard deviation could be better applied the scale of suburban districts. The significant factor number and importance value also vary with the scale of analysis. More significant factors are related to NTL at a smaller scale. With such information, we can understand how the city develops at different levels through NTL changes and which factors are the most significant in these development processes at a particular scale. The development of an entire city could be comprehensively explained and insightful information can be produced for urban planners to make more accurate development plans in future.
The Role of Modeling Landscape Values by Harmonizing Conservation and Development Requirements
Authors: Tomić Reljić Dora , Hrdalo Ines , Kamenečki Monika , Pereković Petra , Butula Sonja
Published: January 2023

This paper investigated the need for the inquiry of landscape values and public participation within the decision-making process on spatial changes. They are taken into account as an important segment in the harmonization of conservation and development requirements in the planning of sustainable spatial development. The method for obtaining that information was established, and new approaches in landscape research were tested through the perception of its values as the first step to solving the conflicts between spatial conservation and development. Through the research of the experiences and theoretical knowledge on the nature protection issues within the spatial planning context, this paper indicated the need for determination of the effectiveness of the standardization approach to nature protection. Also, it emphasized the importance of testing a possible application of new approaches, which would be based on a mutually agreed approach to the protection and development of space. Modeling the landscape qualities of the space was presented as a basic tool within the presentation methodology and within the inclusion of different public segments in the spatial planning procedure. Its usefulness has been shown in the possibility of preparing the cartographic presentation of the harmonized model, which simultaneously includes the opinions of all relevant groups and can be easily implemented in the planning procedure using the GIS tools before decision-making. This paper pointed out that such an approach contributes to solving the practical problems in the protection of landscape qualities that represent public good and the link between nature and culture, and biophysical, perceptional, social, and developmental elements within the space.
The Causes of the Occurrence and Spheres of Restoration of Chateau Brownfields: A Search for Causality on the Example of Properties in the Moravian-Silesian Region, Czech Republic
Authors: Turečková Kamila
Published: January 2023

Scientific research in the area of chateau brownfields is quite new and thus offers room for interesting findings and insights. This text presents the results of a pilot study in search of causality between the causes of the occurrence and spheres of restoration of chateau brownfields in the Moravian-Silesian region in the Czech Republic, where chateau settlements are considered an urban phenomenon of the cultural landscape. Out of a total of 88 chateaux, 40 have received brownfield status over the years, of which 28 are currently regenerated. The main reason why the chateaux were abandoned can be found in the inappropriate economic activities that took place in them, which originated mainly in the directive decision on their functionality at the end of the Second World War. Most of the chateau brownfield sites are still abandoned or currently for sale, and many others have been regenerated for tourism and public sector services. The causality analysed between the causes of their occurrence and their restored function reflects the logical and economic context characteristic of a time of restoration and the general desire of the public sector to reduce the number of brownfield sites in its cadastral area.
Brownfield Data and Database Management—The Key to Address Land Recycling
Authors: Rebernik Lea , Vojvodíková Barbara , Lampič Barbara
Published: January 2023

Brownfields sometimes represent a development problem but at the same time also hold development potential. With accurate and up-to-date information it is possible to assure the regeneration process is effective; therefore we investigated in detail the development of the process of brownfields management in two countries: Slovenia and the Czech Republic (the Moravian-Silesian Region). The article compares the process of development of databases and the data itself in both selected case studies, and evaluates and identifies the patterns of change in brownfields with a focus on regenerated sites. In the period 2017–2022 we have noticed a growing number of brownfields included in databases in both selected cases, despite the share of regenerated brownfield sites that have been excluded from the database. Both study cases show that ensuring continuity of work in the process of monitoring brownfields and knowledge transfer are critical for sustainable brownfield management and successful regeneration. Based on the comparisons, recommendations are summarised on how to make the database an effective tool that could be relevant to more sustainable brownfield development and land recycling.
Simulating Future Land Use and Cover of a Mediterranean Mountainous Area: The Effect of Socioeconomic Demands and Climatic Changes
Authors: Kiziridis Diogenis A. , Mastrogianni Anna , Pleniou Magdalini , Tsiftsis Spyros , Xystrakis Fotios , Tsiripidis Ioannis
Published: January 2023

Land use and cover (LUC) of southern European mountains is dramatically changing, mainly due to observed socioeconomic demands and climatic changes. It is therefore important to understand LUC changes to accurately predict future landscapes and their threats. Simulation models of LUC change are ideal for this task because they allow the in silico experimentation under different socioeconomic and climatic scenarios. In the present study, we employed the trans-CLUE-S model, to predict for 2055 the LUC of a typical southern European sub-mountainous area, which has experienced widespread abandonment until recently. Four demand scenarios were tested, and under each demand scenario, we compared three climatic scenarios, ranging from less to more warm and dry conditions. We found that farmland declined from 3.2% of the landscape in 2015 to 0.4% in 2055 under the business-as-usual demand scenario, whereas forest further increased from 62.6% to 79%. For any demand scenario, differences in LUC between maps predicted under different climatic scenarios constituted less than 10% of the landscape. In the less than 10% that differed, mainly farmland and forest shifted to higher elevation under a warmer and drier climate, whereas grassland and scrubland to lower. Such insights by modelling analyses like the present study’s can improve the planning and implementation of management and restoration policies which will attempt to conserve ecosystem services and mitigate the negative effects of socioeconomic and climatic changes in the mountainous regions of southern Europe.
Modelling the Whole Profile Soil Organic Carbon Dynamics Considering Soil Redistribution under Future Climate Change and Landscape Projections over the Lower Hunter Valley, Australia
Authors: Ma Yuxin , Minasny Budiman , Viaud Valérie , Walter Christian , Malone Brendan , McBratney Alex
Published: January 2023

Soil organic carbon (SOC) storage and redistribution across the landscape (through erosion and deposition) are linked to soil physicochemical properties and can affect soil quality. However, the spatial and temporal variability of soil erosion and SOC remains uncertain. Whether soil redistribution leads to SOC gains or losses continues to be hotly debated. These considerations cannot be modelled using conventional soil carbon models and digital soil mapping. This paper presents a coupled-model combining RothPC-1 which considers soil carbon (C) down to 1 m and a soil redistribution model. The soil redistribution component is based on a cellular automata technique using the multi-direction flow (FD8) algorithm. With the optimized input values based on land use, we simulated SOC changes upon soil profiles to 1 m across the Lower Hunter Valley area (11,300 ha) in New South Wales, Australia from the 1970s to 2016. Results were compared to field observations and showed that erosion was predicted mostly in upslope areas and deposition in low-lying areas. We further simulated SOC trends from 2017 until ~2045 in the area under three climate scenarios and five land use projections. The variation in the magnitude and direction of SOC change with different projections shows that the main factors influencing SOC changes considering soil redistribution are climate change which controlled the trend of SOC stocks, followed by land use change. Neglecting soil erosion in carbon models could lead to an overestimation of SOC stocks. This paper provides a framework for incorporating soil redistribution into the SOC dynamics modelling and also postulates the thinking that soil erosion is not just a removal process by surface runoff.
A Critical Review on the Perspectives of the Forestry Sector in Ecuador
Authors: Castillo Vizuete Danny Daniel , Gavilanes Montoya Alex Vinicio , Chávez Velásquez Carlos Renato , Borz Stelian Alexandru
Published: January 2023

The contribution of the Ecuadorian forest industry to the development of the country is of undeniable importance since it enables job creation, the production of goods and services, and the generation of wealth. As such, special attention should be paid to the problems that are affecting its development and that prevent enhancing the competitiveness of the companies in this important productive sector of the country. This review of the international literature found in relevant databases synthesizes findings on the forest wealth of Ecuador vs. deforestation. We also provide an overview on the state-of-art technology in timber harvesting and the wood processing industry. Within each of these topics, we analyze and discuss some factors such as irrational logging of native forests, incipient afforestation, as well as the elements on primary and secondary transformation of wood in Ecuador. We conclude that the participation and cooperation of all actors in the productive chain of the forestry sector in Ecuador is of the utmost importance to adequately address the demands of the national and international markets.
Swelling Cities? Detecting China’s Urban Land Transition Based on Time Series Data
Authors: Pan Wei , Wang Jing , Lu Zhi , Li Yurui
Published: January 2023

It is common to see urban land expansion worldwide, and its characteristics, mechanisms, and effects are widely known. As socio-economic transition and the change of land use policies may reverse the trend of urban expansion, in-depth research on the process of urban land use change is required. Through a process perspective, this paper reveals the change paths, development stages, and spatial patterns of urban residential land use with data from 323 cities in China from 2009 to 2016. The results show that: (1) theoretically, urban residential land use change can be divided into four development stages: an initial stage (Ⅰ), a rapid development stage (Ⅱ), a transition stage (Ⅲ), and a later stage of transition (Ⅳ). The rate of land use change is low—increase—decrease—approaching zero. (2) In about 68.7% of China’s cities, urban residential land is experiencing a transition, shifting from accelerating growth to decelerating growth. Given the distinctive transition process, it has been suggested that urban planning and land use policies should give timely responses to the new trends and spatial differences.
Children’s Developmental (Im)maturity: Aligning Conflicting Decisional Capacity Assessment Approaches in Australia
Authors: Moritz Dominique
Published: January 2023

Children’s decision-making is complex. There are many factors that contribute to children’s decisional capacity including cognitive reasoning, developmental maturity, upbringing and circumstances. For healthcare decisions, Australian law acknowledges children’s autonomy, and permits mature children to consent to beneficial healthcare. Yet, it also protects them from making life-changing decisions that could contravene their best interests. The criminal law approaches to children’s decision-making in Australia’s jurisdictions involves holding older children fully responsible for their decision-making, regardless of circumstances or maturity. The two approaches conflict because health law offers a protective mechanism for children yet criminal law imposes a punitive approach to children’s decision-making. This article considers whether the dichotomous approaches for children’s capacity assessments in Australian law can be reconciled.