bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcomes of the resuscitative and emergency thoracotomy at a Dutch level-one trauma center: are there predictive factors for survival?
Authors: Sam A. S. Y. , Nawijn F. , Benders K. E. M. , Houwert R. M. , Leenen L. P. H. , Hietbrink F.
Published: June 2022

Purpose

To investigate the 30-day survival rate of resuscitative and emergency thoracotomies in trauma patients. Moreover, factors that positively influence 30-day survival rates were investigated.

Methods

A retrospective study of patients (> 16 years), between 2008 and 2020, who underwent a resuscitative or emergency thoracotomy at a level-one trauma center in the Netherlands was conducted.

Results

Fifty-six patients underwent a resuscitative (n = 45, 80%) or emergency (n = 11, 20%) thoracotomy. The overall 30-day survival rate was 32% (n = 18), which was 23% after blunt trauma and 72% after penetrating trauma, and which was 18% for the resuscitative thoracotomy and 91% for the emergency thoracotomy. The patients who survived had full neurologic recovery. Factors associated with survival were penetrating trauma (p < 0.001), (any) sign of life (SOL) upon presentation to the hospital (p = 0.005), Glasgow Coma Scale (GCS) of 15 (p < 0.001) and a thoracotomy in the operating room (OR) (p = 0.018). Every resuscitative thoracotomy after blunt trauma and pulseless electrical activity (PEA) or asystole in the pre-hospital phase was futile (0 survivors out of 11 patients), of those patients seven (64%) had concomitant severe neuro-trauma.

Conclusion

This study found a 30-day survival rate of 32% for resuscitative and emergency thoracotomies, all with good neurological recovery. Factors associated with survival were related to the trauma mechanism, the thoracotomy indication and response to resuscitation prior to thoracotomy (for instance, if resuscitation enables enough time for safe transport to the operating room, survival chances increase). Resuscitative thoracotomies after blunt trauma in combination with loss of SOL before arrival at the emergency room were in all cases futile, interestingly in nearly all cases due to concomitant neuro-trauma.
Hydrolysierte Säuglingsnahrung für die Allergieprävention – wissenschaftliche Evidenz und Empfehlungen für die Praxis
Authors: Ghoreishi Narges , Riedmüller Jonathan , Knüppel Sven , Müller-Graf Christine , Weißenborn Anke
Published: June 2022

Hintergrund

Laut S3-Leitlinie „Allergieprävention“ (Update 2021) soll bei nicht (voll) gestillten Säuglingen mit erhöhtem Allergierisiko geprüft werden, ob eine Säuglingsnahrung mit nachgewiesener allergiepräventiver Wirksamkeit verfügbar ist. Einige Hersteller bewerben ihre Produkte entsprechend.

Ziel der Arbeit

Der Artikel gibt einen Überblick über die wissenschaftliche Evidenz und internationale Empfehlungen zum Einsatz von hydrolysierter Säuglingsnahrung (sog. hypoallergene [HA-]Nahrung) zur Prävention von atopischen Erkrankungen.

Materialien und Methoden

In medizinischen Datenbanken wurde eine Literaturrecherche (Zeitraum: 2016–2021) zum Nutzen von hydrolysierten Säuglingsnahrungen für die Allergieprävention bei Risikokindern und zu entsprechenden internationalen Leitlinien durchgeführt. Auf dieser Basis wurden die aktuelle Empfehlung der deutschen S3-Leitlinie sowie die Produkte auf dem deutschen Markt eingeordnet.

Ergebnisse

Es gibt keine hinreichenden Belege für einen generellen allergiepräventiven Nutzen von Säuglingsnahrungen mit Proteinhydrolysat bei Säuglingen mit erhöhtem Allergierisiko. Die GINI-Interventionsstudie deutet darauf hin, dass eine der eingesetzten Hydrolysatnahrungen zur Prävention atopischer Dermatitis bei Risikokindern wirksam gewesen sein könnte. Die Ergebnisse können aber, auch angesichts methodischer Schwächen, nicht als alleinige Basis für eine allgemeine Empfehlung zur Verwendung von HA-Nahrung herangezogen werden. Internationale Fachgesellschaften sprechen sich seit einigen Jahren eher gegen eine solche Empfehlung aus.

Diskussion

Für die derzeit in Deutschland vermarkteten Säuglingsnahrungen auf Basis von partiell hydrolysiertem Protein fehlen Wirksamkeitsbelege. Sie können daher nicht zur Allergieprävention empfohlen werden.
Landownership concentration and human capital accumulation in post-unification Italy
Authors: Mariella Vitantonio
Published: June 2022

This paper contributes to the debate on institutions and economic development by assessing the relationship between landownership concentration and education. Using historical data at both the district and province levels in post-unification Italy from 1871 to 1921, I find evidence of an adverse effect of land inequality on literacy rates. Instrumental variable estimates using malaria pervasiveness as a source of exogenous variation rule out concerns regarding potential endogeneity. Exploration of the panel dimension of the data reveals that several shocks during this period affected the relationship between land inequality and literacy rates. In addition, this paper provides insights into the mechanism behind this relationship by analyzing the impact on intermediate outputs, such as enrollment rates in primary school, child-teacher ratio, school density, child labor, and municipality expenditures. Land inequality may have adversely affected literacy rates not only by influencing schooling supply through the political process but also through the private demand for education.
Methods in food defence: a simple and robust screening for 16 rodenticides by LC-DAD/FLD following QuEChERS–based extraction
Authors: Menacher Georg , Masberg Benedikt , Elsinghorst Paul W.
Published: June 2022

Fortunately, the intentional contamination of food or water supplies out of criminal or terroristic motivation is a rather rare event. However, in the face of asymmetric warfare and as the consequences of such an event would be severe, food defence as a necessary supplement to food safety is gaining increased attention. While some progress has been made in developing non-target detection devices, the contamination of food or water supplies using readily available rodenticides may still be revealed only by complex analytical techniques. The presented study therefore aimed to develop a quick and easy screening method for the detection of sixteen globally common rodenticides in foodstuffs. Robust operation with limited personnel and analytical resources were one benchmark to be met by the method, which uses a slightly modified QuEChERS (quick, easy, cheap, effective, rugged, safe) protocol for dispersive solid-phase extraction and subsequent ion-pair chromatography with diode-array and fluorescence detection. Quantification limits were as low as 5 µg/kg with satisfying bias (recovery) and repeatability rates of 77 to 117% and 1.8 to 17.1%, respectively. The developed method provides reliable and robust detection of these deadly poisons at toxic concentrations, which was demonstrated impressively in an improvised assault scenario.
A new concept of the fiber composition of cervical spinal dura mater: an investigation utilizing the P45 sheet plastination technique
Authors: Zhuang Jing , Gong Jin , Hack Gary D. , Chi Yan-Yan , Song Yang , Yu Sheng-Bo , Sui Hong-Jin
Published: June 2022

Purpose

Few reports have been published regarding the microanatomy of the dura mater located at the craniovertebral junction (CVJ). In clinic, the precise microanatomy of the CVJ dura mater would be taken into account, for reducing surgical complications and ineffective surgical outcomes. The main objective of the present investigation was to further elucidate the fiber composition and sources of the cervical spinal dura mater.

Methods

The formalin-fixed adult head and neck specimens (n = 21) were obtained and P45 plastinated section method was utilized for the present study. The fibers of the upper cervical spinal dura mater (SDM) were examined in the P45 sagittal sections in the CVJ area. All photographic documentation was performed via a Canon EOS 7D Mark camera.

Results

The posterior wall of the SDM sac at CVJ was found to be composed of stratified fibers, which are derived from three sources: the cerebral dura mater, the occipital periosteum, and the myodural bridge (MDB). The proper layer of the cerebral dura mater passes over the brim of the foramen magnum and enters the vertebral canal to form the inner layer of the SDM, and the fibers originating from the periosteum of the brim of the foramen magnum form the middle layer. The fibers of the MDB are inserted into the SDM and form its outer layer. It was found that the total number of fibers from each origin varied in humans.

Conclusion

At the CVJ, the posterior wall of the SDM is a multi-layered structure composed of three different originated fibers. The cerebral dura mater, the periosteum located at the brim of the foramen magnum, and MDB contribute to the formation of the SDM. The present study would be beneficial to the choice of surgical approach at the CVJ and the protection of the SDB.
Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
Authors: Carrasco Raquel , Ingelmo-Torres Mercedes , Gómez Ascensión , Roldán Fiorella L. , Segura Natalia , Ribal María José , Alcaraz Antonio , Izquierdo Laura , Mengual Lourdes
Published: June 2022

Purpose

Current clinical prognostic factors are not accurate enough to identify and monitor those muscle-invasive bladder cancer (MIBC) patients at high risk of progression after radical cystectomy (RC). Here, we determined genetic alterations in the tumor and circulating tumor cell (CTC) enumeration to find biomarkers useful for the management of MIBC after RC.

Methods

Thirty-nine MIBC patients undergoing RC were included. Tumoral tissue DNA was analyzed by next generation sequencing. CTCs were isolated from blood collected before RC and one, four and 12 months later.

Results

Sixteen (41%) patients progressed in a median time of 8.5 months and 11 (69%) of these patients harbored the TERT c.-124C > T mutation. All progressive patients harboring the TERT c.-124C > T mutation presented a significant increase in CTC number 12 months after RC compared to those without the mutation. Additionally, CTC number at 12 months was identified as an independent prognostic biomarker for tumor progression and cancer specific survival (CSS). Ten (63%) progressive patients showed an increment of CTC number with a median anticipation period of four months compared with imaging techniques.

Conclusions

The TERT c.-124C > T mutation could be considered a biomarker of aggressivity. CTC enumeration is a useful tool for identifying MIBC patients at high risk of progression and CSS after RC and for detecting tumor progression earlier than imaging techniques.
Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy
Authors: Berdowski Woutje M. , van der Linde Herma C. , Breur Marjolein , Oosterhof Nynke , Beerepoot Shanice , Sanderson Leslie , Wijnands Lieve I. , de Jong Patrick , Tsai-Meu-Chong Elisa , de Valk Walter , de Witte Moniek , van IJcken Wilfred F. J. , Demmers Jeroen , van der Knaap Marjo S. , Bugiani Marianna , Wolf Nicole I. , van Ham Tjakko J.
Published: June 2022

Tissue-resident macrophages of the brain, including microglia, are implicated in the pathogenesis of various CNS disorders and are possible therapeutic targets by their chemical depletion or replenishment by hematopoietic stem cell therapy. Nevertheless, a comprehensive understanding of microglial function and the consequences of microglial depletion in the human brain is lacking. In human disease, heterozygous variants in CSF1R, encoding the Colony-stimulating factor 1 receptor, can lead to adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) possibly caused by microglial depletion. Here, we investigate the effects of ALSP-causing CSF1R variants on microglia and explore the consequences of microglial depletion in the brain. In intermediate- and late-stage ALSP post-mortem brain, we establish that there is an overall loss of homeostatic microglia and that this is predominantly seen in the white matter. By introducing ALSP-causing missense variants into the zebrafish genomic csf1ra locus, we show that these variants act dominant negatively on the number of microglia in vertebrate brain development. Transcriptomics and proteomics on relatively spared ALSP brain tissue validated a downregulation of microglia-associated genes and revealed elevated astrocytic proteins, possibly suggesting involvement of astrocytes in early pathogenesis. Indeed, neuropathological analysis and in vivo imaging of csf1r zebrafish models showed an astrocytic phenotype associated with enhanced, possibly compensatory, endocytosis. Together, our findings indicate that microglial depletion in zebrafish and human disease, likely as a consequence of dominant-acting pathogenic CSF1R variants, correlates with altered astrocytes. These findings underscore the unique opportunity CSF1R variants provide to gain insight into the roles of microglia in the human brain, and the need to further investigate how microglia, astrocytes, and their interactions contribute to white matter homeostasis.
Extraocular muscle enlargement
Authors: Rana Khizar , Juniat Valerie , Patel Sandy , Selva Dinesh
Published: June 2022

Extraocular muscle enlargement can occur secondary to a range of orbital and systemic diseases. Although the most common cause of extraocular muscle enlargement is thyroid eye disease, a range of other inflammatory, infective, neoplastic, and vascular conditions can alter the size and shape of the extraocular muscles. Imaging with computed tomography and magnetic resonance imaging plays an essential role in the workup of these conditions. This article provides an image-rich review of the wide range of pathology that can cause enlargement of the extraocular muscles.
The significance of the extent of tissue embedding for the detection of incidental prostate carcinoma on transurethral prostate resection material: the more, the better?
Authors: Köllermann Jens , Hoeh Benedikt , Ruppel Daniel , Smith Kevin , Reis Henning , Wenzel Mike , Preisser Felix , Kosiba Marina , Mandel Philipp , Karakiewicz Pierre I. , Becker Andreas , Chun Felix K. H. , Wild Peter , Kluth Luis A.
Published: June 2022

The aim of this study is to investigate the incidental prostate cancer (iPCa) detection rates of different embedding methods in a large, contemporary cohort of patients with bladder outlet obstruction (BOO) treated with transurethral surgery. We relied on an institutional tertiary-care database to identify BOO patients who underwent either transurethral loop resection or laser (Holmium:yttrium–aluminium garnet) enucleation of the prostate (HoLEP) between 01/2012 and 12/2019. Embedding methods differed with regard to the extent of the additional prostate tissue submitted following the first ten cassettes of primary embedding (cohort A: one [additional] cassette/10 g residual tissue vs. cohort B: complete embedding of the residual tissue). Detection rates of iPCa among the different embedding methods were compared. Subsequently, subgroup analyses by embedding protocol were repeated in HoLEP-treated patients only. In the overall cohort, the iPCa detection rate was 11% (46/420). In cohort A (n = 299), tissue embedding resulted in a median of 8 cassettes/patient (range 1–38) vs. a median of 15 (range 2–74) in cohort B (n = 121) (p < .001). The iPCa detection rate was 8% (23/299) and 19% (23/121) in cohort A vs. cohort B, respectively (p < .001). Virtual reduction of the number of tissue cassettes to ten cassettes resulted in a iPCa detection rate of 96% in both cohorts, missing one stage T1a/ISUP grade 1 carcinoma. Increasing the number of cassettes by two and eight cassettes, respectively, resulted in a detection rate of 100% in both cohorts without revealing high-grade carcinomas. Subgroup analyses in HoLEP patients confirmed these findings, demonstrated by a 100 vs. 96% iPCa detection rate following examination of the first ten cassettes, missing one case of T1a/ISUP 1. Examination of 8 additional cassettes resulted in a 100% detection rate. The extent of embedding of material obtained from transurethral prostate resection correlates with the iPCa detection rate. However, the submission of 10 cassettes appears to be a reasonable threshold to reduce resource utilization while maintaining secure cancer detection.
Inhibition of angiogenesis and tumor progression of MK-0429, an integrin αvβ3 antagonist, on oral squamous cell carcinoma
Authors: Nakagawa Takayuki , Ohta Kouji , Naruse Takako , Sakuma Miyuki , Fukada Syohei , Yamakado Nao , Akagi Misaki , Sasaki Kazuki , Niwata Chieko , Ono Shigehiro , Aikawa Tomonao
Published: June 2022

Purpose

Integrin αvβ3 is an essential molecule for tumor angiogenesis. This study aimed to investigate the anti-tumor effect of MK-0429, an integrin αvβ3 antagonist, on oral squamous cell carcinoma (OSCC) through its inhibitory effect on angiogenesis.

Methods

In this study, we investigated the effect of MK-0429 on cellular function and angiogenesis in vitro with the use of an immortalized human umbilical vein endothelial cell, HUEhT-1, which is immortalized by the electroporatic transfection of hTERT. The effect of MK-0429 on the integrin αvβ3 signaling pathway was examined by FAK, MEK1/2 and ERK 1/2 phosphorylation. The anti-angiogenic effect of MK-0429 was evaluated by in vitro tube formation assay. The anti-tumor effect on OSCC was assessed by administrating MK-0429 to mouse oral cancer xenografts.

Results

MK-0429 inhibited cell proliferation, migration, and adhesion of HUEhT-1 in a dose-dependent manner. FAK, MEK and ERK phosphorylation were significantly blocked by MK-0429 treatment. Tube formation was suppressed by MK-0429 in dose-dependent manner. Tumor progression was significantly suppressed by MK-0429 administration in mouse oral cancer xenografts. Histological study revealed that MK-0429 decreased tumor vascularization.

Conclusion

These results indicated integrin αvβ3 as a therapeutic target for OSCC and suggested that MK-0429 might be clinically applicable as an anti-tumor agent with potent anti-angiogenic activity.
Edgeworth approximations for distributions of symmetric statistics
Authors: Bloznelis Mindaugas , Götze Friedrich
Published: June 2022

We study the distribution of a general class of asymptotically linear statistics which are symmetric functions of N independent observations. The distribution functions of these statistics are approximated by an Edgeworth expansion with a remainder of order $$o(N^{-1})$$

o
(

N

-
1

)

. The Edgeworth expansion is based on Hoeffding’s decomposition which provides a stochastic expansion into a linear part, a quadratic part as well as smaller higher order parts. The validity of this Edgeworth expansion is proved under Cramér’s condition on the linear part, moment assumptions for all parts of the statistic and an optimal dimensionality requirement for the non linear part.
Management of the congenital solitary kidney: consensus recommendations of the Italian Society of Pediatric Nephrology
Authors: La Scola Claudio , Ammenti Anita , Bertulli Cristina , Bodria Monica , Brugnara Milena , Camilla Roberta , Capone Valentina , Casadio Luca , Chimenz Roberto , Conte Maria L. , Conversano Ester , Corrado Ciro , Guarino Stefano , Luongo Ilaria , Marsciani Martino , Marzuillo Pierluigi , Meneghesso Davide , Pennesi Marco , Pugliese Fabrizio , Pusceddu Sara , Ravaioli Elisa , Taroni Francesca , Vergine Gianluca , Peruzzi Licia , Montini Giovanni
Published: June 2022

Background

In recent years, several studies have been published on the prognosis of children with congenital solitary kidney (CSK), with controversial results, and a worldwide consensus on management and follow-up is lacking. In this consensus statement, the Italian Society of Pediatric Nephrology summarizes the current knowledge on CSK and presents recommendations for its management, including diagnostic approach, nutritional and lifestyle habits, and follow-up.

Summary of the recommendations

We recommend that any antenatal suspicion/diagnosis of CSK be confirmed by neonatal ultrasound (US), avoiding the routine use of further imaging if no other anomalies of kidney/urinary tract are detected. A CSK without additional abnormalities is expected to undergo compensatory enlargement, which should be assessed by US. We recommend that urinalysis, but not blood tests or genetic analysis, be routinely performed at diagnosis in infants and children showing compensatory enlargement of the CSK. Extrarenal malformations should be searched for, particularly genital tract malformations in females. An excessive protein and salt intake should be avoided, while sport participation should not be restricted. We recommend a lifelong follow-up, which should be tailored on risk stratification, as follows: low risk: CSK with compensatory enlargement, medium risk: CSK without compensatory enlargement and/or additional CAKUT, and high risk: decreased GFR and/or proteinuria, and/or hypertension. We recommend that in children at low-risk periodic US, urinalysis and BP measurement be performed; in those at medium risk, we recommend that serum creatinine also be measured; in high-risk children, the schedule has to be tailored according to kidney function and clinical data.
Heat stress in Africa under high intensity climate change
Authors: Parkes B. , Buzan J. R. , Huber M.
Published: June 2022

Extreme weather events are major causes of loss of life and damage infrastructure worldwide. High temperatures cause heat stress on humans, livestock, crops and infrastructure. Heat stress exposure is projected to increase with ongoing climate change. Extremes of temperature are common in Africa and infrastructure is often incapable of providing adequate cooling. We show how easily accessible cooling technology, such as evaporative coolers, prevent heat stress in historic timescales but are unsuitable as a solution under climate change. As temperatures increase, powered cooling, such as air conditioning, is necessary to prevent overheating. This will, in turn, increase demand on already stretched infrastructure. We use high temporal resolution climate model data to estimate the demand for cooling according to two metrics, firstly the apparent temperature and secondly the discomfort index. For each grid cell we calculate the heat stress value and the amount of cooling required to turn a heat stress event into a non heat stress event. We show the increase in demand for cooling in Africa is non uniform and that equatorial countries are exposed to higher heat stress than higher latitude countries. We further show that evaporative coolers are less effective in tropical regions than in the extra tropics. Finally, we show that neither low nor high efficiency coolers are sufficient to return Africa to current levels of heat stress under climate change.
Investigation of the Impact of Powder Shape on Spreading Dense Layers Using the Spreading Tester
Authors: Mitterlehner Marco , Gschiel Harald , Danninger Herbert , Gierl-Mayer Christian
Published: June 2022

In Laser Beam Powder Bed Fusion (LB-PBF) technologies, spreading of powder layers as dense and as fully covered as possible is of crucial importance for a good processability of powders. Poorly covered layers or layers with undesirable features in it, such as elongated, powderless craters in the direction of spreading, might result in defective printed parts. The reason for this could be either poor powder quality or a poorly adjusted build job. To investigate the surface coverage of a single spread powder layer, a new method was developed using the Spreading Tester. With this, two powder grades differing mostly in their particle shape were used to investigate the impact of powder shape on the surface coverage.
Negative sulfur-based electrodes and their application in battery cells: Dual-ion batteries as an example
Authors: Küpers Verena , Kolek Martin , Bieker Peter , Stan Marian Cristian , Placke Tobias , Winter Martin
Published: June 2022

In this work, a cell concept comprising of an anion intercalating graphite-based positive electrode (cathode) and an elemental sulfur-based negative electrode (anode) is presented as a transition metal- and in a specific concept even Li-free cell setup using a Li-ion containing electrolyte or a Mg-ion containing electrolyte. The cell achieves discharge capacities of up to 37 mAh g−1 and average discharge cell voltages of up to 1.9 V. With this setup, more than 100 cycles with a high capacity retention (> 90% of the highest achieved value) and Coulombic efficiencies up to 95% could be achieved, which opens a broad new field for energy storage approaches.
Commentary on “Extending the Basic Local Independence Model to Polytomous Data” by Stefanutti, de Chiusole, Anselmi, and Spoto
Authors: Chiu Chia-Yi , Köhn Hans Friedrich , Ma Wenchao
Published: June 2022

The Polytomous Local Independence Model (PoLIM) by Stefanutti, de Chiusole, Anselmi, and Spoto, is an extension of the Basic Local Independence Model (BLIM) to accommodate polytomous items. BLIM, a model for analyzing responses to binary items, is based on Knowledge Space Theory, a framework developed by cognitive scientists and mathematical psychologists for modeling human knowledge acquisition and representation. The purpose of this commentary is to show that PoLIM is simply a paraphrase of a DINA model in cognitive diagnosis for polytomous items. Specifically, BLIM is shown to be equivalent to the DINA model when the BLIM-items are conceived as binary single-attribute items, each with a distinct attribute; thus, PoLIM is equivalent to the DINA for polytomous single-attribute items, each with a distinct attribute.
Chinese or western finance? Transparency, official credit flows, and the international political economy of development
Authors: Cormier Ben
Published: June 2022

Why do some developing countries obtain more official finance from China vis-a-vis Western sources? This study finds borrower transparency significantly affects which governments borrow more from China. From a supply side perspective, Chinese lending agencies have incentives to lend more to untransparent borrowers. From a demand side perspective, untransparent borrowers have incentives to use Chinese finance to avoid Western pressure to become more transparent. These findings and explanations have three implications. First, they help explain variation in external debt composition across developing countries using official credit. Second, they have implications for the international political economy of developing countries’ financial ties to China. Third, they imply the use of Chinese finance may allow untransparent governments to remain so, an important implication for the political economy of development.
Should older people ever be discharged from hospital at night?
Authors: Hyslop Brent
Published: June 2022

The discharge of older people from hospital at night is a topical and emotive issue that has recently gained media attention in New Zealand and the United Kingdom, including calls to prevent it occurring. With growing pressures on hospital capacity and ageing populations, normative aspects of hospital discharge are increasingly relevant. This paper therefore addresses the question: Should older people (say, over eighty years old) ever be discharged home from hospital during the night? Or given safety concerns, should regulation against the night-time discharge of older people be put in place? Employing a principlist lens to bioethics, this paper considers key principles or values involved, including discharge safety concerns, personal preference and consent, the risk of remaining in hospital, and broader considerations around discharge policy. These points act as a possible framework for further research and discussion of normative aspects of hospital discharge. Overall, this paper argues that while discharge safety concerns must be properly acknowledged and addressed, it can still sometimes be appropriate for an older person to leave hospital at night. The option of night-time discharge should therefore remain open to people of all ages.
Evaluation of Rare Earth Element-Associated Hormetic Effects in Candidate Fertilizers and Livestock Feed Additives
Authors: Tommasi Franca , Thomas Philippe J. , Lyons Daniel M. , Pagano Giovanni , Oral Rahime , Siciliano Antonietta , Toscanesi Maria , Guida Marco , Trifuoggi Marco
Published: June 2022

Rare earth elements (REEs) are recognized as emerging contaminants with implications in human and environmental health. Apart from their adverse effects, REEs have been reported as having positive effects when amended to fertilizers and livestock feed additives, thus suggesting a hormetic trend, implying a concentration-related shift from stimulation to inhibition and toxicity, with analogous trends that have been assessed for a number of xenobiotics. In view of optimizing the success of REE mixtures in stimulating crop yield and/or livestock growth or egg production, one should foresee the comparative concentration-related effects of individual REEs (e.g., Ce and La) vs. their mixtures, which may display distinct trends. The results might prompt further explorations on the use of REE mixtures vs. single REEs aimed at optimizing the preparation of fertilizers and feed additives, in view of the potential recognition of their use in agronomy and zootechny.
Little Evidence for Conservative Toe Walking Interventions in Autism Spectrum Disorders: a Systematic Review
Authors: Valagussa Giulio , Piscitelli Daniele , Baruffini Silvia , Panzeri Valentina , Perin Cecilia , Mazzucchelli Miryam , Cornaggia Cesare Maria , Pellicciari Leonardo , Grossi Enzo
Published: June 2022

This systematic review summarizes the evidence about toe walking (TW) interventions in persons with autism. Following the PRISMA guidelines, a systematic search of MEDLINE, CINAHL, PsycINFO, The Cochrane Library, Google Scholar, and Opengrey was performed. Nine articles (all case reports or case series) were included. Methodological quality was assessed using the Mayo Evidence-Based Practice Centre tool. The included studies considered 17 subjects (16 males; age range: 4–15 years). All studies reported a reduction of TW frequency, but the follow-up was lacking in seven studies. There is a lack of high-quality studies with a sufficiently large and well-characterized sample to assess the effectiveness of TW interventions in autistic persons. These findings strongly support the need for further research in this area.
Referring to Speech Acts in Communication: Exploring Meta-Illocutionary Expressions in ICE-Ireland
Authors: Schneider Klaus P.
Published: June 2022

This paper presents an exploratory study of meta-illocutionary expressions, i.e. of everyday vocabulary such as request, promise and insult, used to explicitly refer to speech acts and to label, discuss and negotiate them in communication. Taking the example of expressions referring to acts of apologising in Irish English, the question is addressed in which contexts, forms and functions these meta-illocutionary expressions are used. Evidence from ICE-Ireland and SPICE-Ireland is employed to demonstrate how this question can be answered empirically, thus providing a model for a corpus-based analysis of such metapragmatic folk terms and how they are used in spoken and written discourse, across genres and illocutionary types. This paper thus offers a blueprint for investigating the meta-illocutionary lexicon of ordinary language users and their first-order conceptualizations of communicative action.
Black-Spot Toxicodendron Dermatitis With Varied Presentation
Authors: Rabinovich Emily P. , Barquin Jennifer N. , Abernathy Rebecca E. , Koester Robert J.
Published: June 2022

This article describes the clinical presentation, differential diagnosis, and treatment of 2 unrelated cases with different presentations of black-spot Toxicodendron dermatitis. In the first case, a healthy 7-y-old male presented with a rash consisting of black dots with localized surrounding erythema on the left arm. The rash then progressed to a vesicular, pinpoint, raised rash spreading to the face, arms, and neck. In the second case, a 4-y-old male presented with non-pruritic, black, flat, non-erythematous lesions that did not progress. This patient’s older sibling had been diagnosed with poison ivy 1 wk prior, and they attended the same child care where the poison ivy was thought to be acquired. In both cases, diagnosis of black-spot Toxicodendron dermatitis was made. The black spot of Toxicodendron dermatitis is caused by urushiol oxidation on exposure to air. The subject may or may not go on to develop allergic contact dermatitis after the exposure. Diagnosis of this dermatitis is made on clinical presentation, with careful consideration of history, distribution, and lesion morphology. When allergic dermatitis does develop as in the first case, systemic treatment with oral steroids is recommended. In both of these cases the black dots completely resolved in 2 to 3 wk. Dermatologic referral for dermoscopy and biopsy may be necessary if the dermatosis does not resolve as anticipated.
Testing Criminal Career Theories in British and American Longitudinal Studies
Authors: MacLeod John F. , Farrington David P.
Published: June 2022

Most criminological theories are not truly scientific, since they do not yield exact quantitative predictions of criminal career features, such as the prevalence and frequency of offending at different ages. This Element aims to make progress towards more scientific criminological theories. A simple theory is described, based on measures of the probability of reoffending and the frequency of offending. Three offender categories are identified: high risk/high rate, high risk/low rate, and low risk/low rate. It is demonstrated that this theory accurately predicts key criminal career features in three datasets: in England the Offenders Index (national data), the Cambridge Study in Delinquent Development (CSDD) and in America the Pittsburgh Youth Study (PYS). The theory is then extended in the CSDD and PYS by identifying early risk factors that predict the three categories. Criminological theorists are encouraged to replicate and build on our research to develop scientific theories that yield quantitative predictions.
D-wave Superconductivity
Authors: Xiang Tao , Wu Congjun
Published: June 2022

This volume provides a comprehensive introduction to the theory of d-wave superconductivity, focused on d-wave pairing symmetry and its physical consequences in the superconducting state. It discusses the basic concepts and methodologies related to high-temperature superconductivity and compares experimental phenomena with theoretical predictions. After a brief introduction to the basic theory of superconductivity and several models for high-temperature superconductivity, this book presents detailed derivations and explanations for various single-particle and collective properties of d-wave superconductors that can be monitored experimentally, including thermodynamics, angular-resolved photo-emission, single-particle and Josephson tunnelling, impurity scattering, magnetic and superfluid responses, transport and optical properties and mixed states. Various universal behaviours of d-wave superconductors are highlighted. Aimed primarily at graduate students and research scientists in condensed matter and materials physics, this text enables readers to understand systematically the physical properties of high-temperature superconductors.
Getting To Implementation (GTI)-Teach: A seven-step approach for teaching the fundamentals of implementation science
Authors: Rogal Shari S. , Jonassaint Charles , Ashcraft LauraEllen , Freburger Janet , Yakovchenko Vera , Kislovskiy Yasaswi , Phares Angela , Hershberger Gretchen , Goodrich David E. , Chinman Matthew
Published: June 2022

Introduction:

Implementation Science (IS) is a complex and rapidly evolving discipline, posing challenges for educators. We developed, implemented, and evaluated a novel, pragmatic approach to teach IS.

Methods:

Getting To Implementation (GTI)-Teach was developed as a seven-step educational model to guide students through the process of developing, conducting, and sustaining an IS research project. During the four-week online course, students applied the steps to self-selected implementation problems. Students were invited to complete two online post-course surveys to assess course satisfaction and self-reported changes in IS knowledge and relevance of GTI-Teach Steps to their work. Results were summarized using descriptive statistics; self-reported post-course changes in IS knowledge were compared using paired t-tests.

Results:

GTI-Teach was developed to include seven Steps: 1. Define the implementation problem; 2. Conceptualize the problem; 3. Prioritize implementation barriers and facilitators; 4. Select and tailor implementation strategies; 5. Design an implementation study; 6. Evaluate implementation; 7. Sustain implementation. Thirteen students, ranging in experience from medical students to full professors, enrolled in and completed the first GTI-Teach course. Of the seven students (54%) completing an end-of course survey, six (86%) were very satisfied with the course. Ten students (77%) responded to the tailored, 6-month post-course follow-up survey. They retrospectively reported a significant increase in their knowledge across all steps of GTI-Teach (1.3–1.8 points on a 5-point Likert scale) and rated each of the Steps as highly relevant to their work.

Conclusions:

GTI-Teach is a seven-step model for teaching IS fundamentals that students reported increased their knowledge and was relevant to their work.
Hybrid warfare: The continuation of ambiguity by other means
Authors: Mumford Andrew , Carlucci Pascal
Published: June 2022

This article presents the study of ambiguity as the essence of hybrid warfare to reconcile it with the international political context. It addresses the gaps in the literature in an effort to elucidate the essence of hybrid warfare not as a separate concept, but rather as the symptom of a changing political environment. The analysis of the literature is reinforced by two case studies: the war in eastern Ukraine of 2014 and the South China Sea dispute. Both these case studies express ambiguity in the combination of kinetic and non-kinetic means used to achieve political objectives. The article rests on three pillars that constitute the architecture of the central argument. The first pillar will address the gap in the current literature on hybrid warfare and how the current debate is too concerned with conflict dynamics rather than its political nature. The second pillar will delineate the essence, characteristics, and value of ambiguity in hybrid warfare. The third pillar will address the practice of hybrid warfare as the conduct of war by great powers.
Cabinet Reshuffles in Latin America: A Function of Presidential Reputation
Authors: Inácio Magna , Llanos Mariana , Pinheiro Bruno
Published: June 2022

In this article we propose an innovative comparative analysis of cabinet reshuffles in Latin American presidential systems, focusing on personal incentives as drivers of ministerial turnover. We analyse when and why risks of reputational damage to a president drive cabinet changes. These risks are contingent and dependent upon the interaction between a president's reputational assets, on the one hand, and the high ‘walk-away value’ of the minister, on the other. We argue that ministerial turnover is a function of presidents' political and reputational resources as well as of exogenous factors. However, who is fired from the cabinet depends on the ministers' walk-away values and how threatened the president feels by them. We analyse cabinet changes in single-party and multiparty presidential governments in Latin America. Our results confirm the explanatory power of personal incentives to better understand the mechanisms that drive cabinet reshuffles.
Online musicking for humanity: the role of imagined listening and the moral economies of music sharing on social media
Authors: Campos Valverde Raquel
Published: June 2022

Music sharing on social media increasingly involves ‘imagined listening’, a form of sociality based on how we think that others listen to music (as well as on our own imagining of sounds) and typically mediated by the exchange of visual prompts, such as the thumbnail images associated with a particular streaming link or recording. Drawing on ethnographic research conducted online and offline with Spanish migrants in London, I show how practices of music sharing based on imagined listening articulate specific moral economies. In these economies, users imbue the sharing of music with positive value, as something that contributes to human flourishing and balances the negative aspects of social media and the world. I also consider how users reckon with the algorithmic manipulations of social media platforms and the fleeting forms of user engagement characteristic of an online world in which there is more music than could ever be heard.
Weaving gender in open collaborative innovation, traditional cultural expressions, and intellectual property: The case of the Tonga baskets of Zambia
Authors: Musiza Charlene
Published: June 2022

This article considers the intersection of gender, traditional cultural expressions, collaborative innovation, and intellectual property in the Tonga Indigenous community of Zambia. Based on a study of the Tonga rural women basket makers who are organized around craft clubs, the study investigated the collaborative environment that fosters the preservation of the cultural tradition of basket weaving, the impact it has had on empowering the women, and the legal protection options available for the Tonga baskets. The study found that Zambia’s 2016 Protection of Traditional Knowledge, Genetic Resources and Expressions of Folklore Act no. 16 (Traditional Knowledge Act) gives automatic protection to traditional cultural expressions and the option for the protection of traditional cultural expressions under the existing intellectual property laws. Though intellectual property protection may not be practical for the Tonga baskets, the Traditional Knowledge Act is a significant step in recognizing the customary values and governance principles in protecting traditional cultural expressions. Registration, in terms of the Traditional Knowledge Act, could enhance the recognition of the baskets, preserve and promote the cultural heritage, and empower the Tonga women.
Fighting Fake News: Using Peer Discussion Groups to Build News Media Literacy
Authors: Siena Susan , Roman Tiffany
Published: June 2022

This article examines the effectiveness of guided peer discussion in building news media literacy. Our longitudinal study finds that this instructional approach increased students’ interest in news headlines, particularly among those with initially low interest. Furthermore, qualitative results show students’ increased awareness of the quality and potential bias of news sources. We conclude that guided peer discussion is an effective means of promoting news media literacy.
Assessing the factorial validity and the internal reliability of the International Trauma Questionnaire (ITQ); PTSD and complex PTSD among survivors of sexual violence in Ireland
Authors: Frost R. , Vang M. Lousion , Hyland P. , Shevlin M. , McCarthy A. , Murphy J.
Published: June 2022

Aims

To assess the factorial validity and internal reliability of the International Trauma Questionnaire (ITQ) among a treatment-seeking sample of survivors of sexual violence in Ireland. In addition, to assess the diagnostic rate of post-traumatic stress disorder (PTSD) and complex post-traumatic stress disorder (CPTSD) among the samples.

Methods

Participants were adult survivors of sexual violence (N = 114) in receipt of therapeutic support at the Dublin Rape Crisis Centre. The ITQ was utilised to measure PTSD and CPTSD symptoms and confirmatory factor analysis was employed to assess the factorial validity of the ITQ. Composite reliability was employed to assess the internal reliability of the ITQ scale scores.

Results

The confirmatory factor analysis results indicated that a six-factor correlated model and a two-factor higher model were good representations of the latent structure of the ITQ, both models are consistent with the conceptualisation of CPTSD. All ITQ subscales possessed satisfactory internal reliability except for the affective dysregulation subscale. Of the sample, 56.1% met the criteria for CPTSD and 20.2% met the criteria for PTSD.

Conclusions

The ITQ captured a distinction between PTSD and CPTSD symptoms and produced reliable scores within the sample, but replication with a larger sample size is required. In addition, the study findings demonstrated that CPTSD was relatively common among those seeking psychological support following sexual violence.
Impacts of drought intensity and weed competition on drought-tolerant corn performance
Authors: Smith Allyson M. , Burns Erin E.
Published: June 2022

Water stress and weed competition are critical stressors during corn (Zea mays L.) development. Genetic improvements in corn have resulted in hybrids with greater tolerance to abiotic and biotic stressors; however, drought stress remains problematic. Therefore, in light of the anticipated change in precipitation throughout the Great Lakes Region, greenhouse experiments were conducted to evaluate water stress and weed competition on drought-tolerant corn performance. The study followed a completely randomized block design with four replications. Factorial treatment combinations consisted of drought-tolerant corn competition (presence or absence), water stress (100% or 50% volumetric water content [VWC]), and nine corn:common lambsquarters (Chenopodium album L., CHEAL) densities. Corn and C. album growth parameters were measured at 14 and 21 d after water-stress initiation. To explore the impact of reduced soil moisture and weed competition on corn and C. album growth parameters, photosynthetic response, and biomass, linear mixed-effects and nonlinear regression models were constructed in R. Chenopodium album biomass was reduced by 46% and 50% under corn competition at 2 and 4 weeds pot−1 (P = 0.0003, 0.0004). However, introducing crop competition under 6 and 9 weeds pot−1 did not reduce C. album biomass (P = 0.90, 1.00). Averaged across weed pressures, corn biomass was 22% less when grown under 50% compared with 100% VWC (P = 0.0003). However, averaged across VWC values, increasing weed competition from 0 to 2 (P = 0.04), 4 (P = <0.0001), 6 (P = 0.0002), or 9 (P = 0.0002) weeds pot−1 reduced biomass by 22%, 38%, 35%, and 36%. Overall, water stress and C. album competition negatively affected the parameters measured in this study; however, the magnitude of reduction is stronger under drought stress than increasing weed competition when water is not limiting. Therefore, field crop growers must modify current integrated weed management programs to maintain yield under future climate stress.