bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioelectrical Brain Activity in Schizophrenic Female Patients with Auditory Verbal Hallucinations
Authors: Leonovich Dar'ya , Shevaldova Ol'ga , Vartanov Aleksandr , Krys'ko Mariya , Zakurazhnaya Valeriya , Ochneva Aleksandra
Published: February 2025

Schizophrenia affects 0.45% of adult population, which is a serious burden for healthcare and social security. It deteriorates the quality of life of patients and their families. Auditory verbal hallucinations prevent schizophrenic patients from professional activities and social interactions. Given that schizophrenic symptoms are gender-specific, the present study focused exclusively on female patients. Understanding the functional characteristics of inner speech in women with schizophrenia has important clinical implications. A deeper comprehension of these neural mechanisms may help to select targeted neuromodulation, pharmacotherapy, and psychotherapy to alleviate the stress and consequences of auditory verbal hallucinations, which share similar psychophysiological mechanisms with inner speech. Auditory verbal hallucinations are a research field that evolves based on qualitative interdisciplinary approaches. These approaches consider both contextual and subjective aspects, as well as their correlations with more general alterations in brain structure and self-perception issues in schizophrenic patients. The research objective was to determine the functional differences during silent pronunciation of stimulus words between female schizophrenic patients with a history of auditory verbal hallucinations and women without mental disorders. The analysis of brain bioelectrical activity patterns relied on a novel method of virtually implanted electrode (Russian Federation Patent No. 2785268). It included two cohorts: control group (22 women, 21–66 y.o.,
mean = 41.9, SD = 16.1) vs. schizophrenic patients of the Alekseev Psychiatric Clinical Hospital No. 1, Moscow (22 women, 23–65 y.o., mean = 41.8, SD = 10.4). The patients were receiving similar pharmacological therapy (17 cases of F20, 3 cases of F23). The stimuli included Russian words sakhar (sugar), shashlyk (barbecue), and raketa (rocket). One instance of raketa was pronounced by a speaker with speech impairments. The participants received the stimuli through headphones in random order while keeping their eyes closed. The study revealed significant differences between women with schizophrenia and the control group: low ERP amplitude in the left Wernicke area (latency 180–210 ms), activation peak delayed by 150 ms in the right Wernicke area, bilateral supramarginal gyrus and left cerebellar region, as well as significant changes in the ventral striatum activity at 180–330 ms.
Applying the Fun Fact Approach for Active Learning
Authors: Sanezi Matteo
Published: February 2025

Social constructivism, introduced by Lev Vygotsky in 1968, has significantly impacted the pedagogical community. It fosters the belief that learning is a collaborative process between students and teachers. While this holds true, simply stating the end goal of education does not guarantee that the path is fully paved. Numerous factors can present obstacles to the complete realization of a student’s potential. Today gamification has become a fundamental aspect of the globalized classroom as a tool to achieve this. The Fun Fact approach (FFA) is an innovative side of gamification, which can be used to foster a successful relationship with the students and to support the acquisition of notions on part of the classroom group. The paper examines how to harness digital advancements to tackle the challenges of education, especially the declining attention spans of students in today's fast-paced environment. We offer an in-depth analysis of the effective implementation of the experimental FFA, emphasizing its advantages, disadvantages, and key areas of application, accompanied by illustrative examples. Within this framework, the paper examines the challenges associated with the FFA, as well as the level of commitment and effort required from educators to utilize it efficiently. The innovative aspect lies in its ability to create an approach that, through careful adjustments and strategic implementation, acts as a flexible and adaptable solution to current educational challenges. Particularly noteworthy is the ability of the Fun Fact approach to tackle the common reluctance among students toward abstract concepts or ideas they view as insignificant. This approach ensures relevance and engagement in the learning process. The implementation of this approach is ideally suited for students in advanced academic settings – those who are mature enough to engage meaningfully with gamification strategies, yet young enough to benefit from the flexibility offered by the FFA. After explaining in detail what the FFA is, we examine its advantages, disadvantages and applications. We look at this approach from the perspective of both a student and a teacher as a means to bolster the acquisition process. We ultimately draw our conclusions by reflecting on how the FFA, when properly implemented and executed, holds promise as an effective solution for modern gamification and teaching practices. Additionally, we provide recommendations on how to prevent its misuse, emphasizing the importance of employing it wisely to maximize academic benefit. The findings demonstrate the potential of the FFA, even in its nascent stage of development. The conclusions highlight the pressing need for this approach in the future, particularly considering the flexibility constraints associated with traditional teaching methods. Traditional methods often struggle to offer the adaptability and engagement necessary to meet the demands of the digital age and the era of globalization.
Legal Communication vs. Representation of Circumstances in Russian Civil Law
Authors: Tishkevich Anton
Published: February 2025

Representations of circumstances and legal communications both describe the exchange of information about facts between participants. They differ in the nature of the information provided and its impact on legal relations. A representation is an incentive for the recipient to make a decision by providing specific information that takes into account the characteristics of the counterparties, individual aspects of the deal, etc. A legal communication is information that has legal significance for civil and legal relations in dynamics. The author compared the key features of representations and legal communications registered in Articles 431.2 and 165.1 of the Civil Code of the Russian Federation. These categories are very similar and demonstrate no substantial controversies; they could be used together but gravitate each to its own specific sphere. They generate legal consequences only together with other elements. Legal communications and representations of circumstances relate to each other as form and content.
Managing Cognitive Functions of Classical Dance Students: Classroom Environment and Pedagogical Conditions
Authors: Alferov Egor
Published: February 2025

Classical dancing develops cognitive functions in junior and middle class students of choreographic schools. The modern media environment forms a fragmentary type of information perception and thinking. The article discusses classroom environment and essential characteristics of classical dance acquisition. Based on the applied character of the discipline, the educational space is a set of pedagogical conditions that implement sequences of functions, from cognitive to analytical and operational, that control and correct motor actions in the learning process. The research, which relied on standard methods, included 45 students aged 9–12 from the Moscow State Academy of Choreography. Based on the theoretical analysis of classical dance teaching in the context of motor skills formation, it yielded specific recommendations on developing professional attention by means of controlling students’ cognitive functions. As a result, the classical dance teacher activates in students those perceptual functions that are necessary at a particular moment of dancing or practicing dance movements.
Bio-aided water filtration: an approach to food processing by-product utilization
Authors: Harinarayanan Nair Chithra , Raman Maya , Tony Amala , Aswathy A.
Published: February 2025

In the wake of industrialization, urbanization, and population growth, the scarcity of readily available freshwater resources has become a great concern and there is an urgent need for energy-efficient, cost-effective, and chemical-free water purification systems. The central treatment plants are considerably expensive and inefficient in certain cases; therefore, low-income countries prefer onsite filtration systems. Chemocoagulants such as aluminium sulphate and ferric chloride work well in water treatment, but they usually require long mining and processing of raw materials and expensive disposal of sludge; further, these may be toxic and could be associated with various health issues, and, thus, cannot be used indefinitely. Coagulation with natural coagulants is a sustainable alternative, which is readily available, economical, convenient, atoxic, less sludge generation, eco-friendly, and effective. In addition to removing contaminants, natural materials can also add nutrients to the water. Hence, these could be used as an alternative for water treatment assuring health security and sustainability. However, natural coagulants are still inadequately accepted; are not commercialized, and are widely applied throughout the world, despite their known benefits. In order to promote a circular economy, more intensive research is needed on natural coagulants to determine their mechanism of action, how they are adopted, and how they can be commercialized.
Bioenergy from forest resources: wood pellets, biochar, and heat generation
Authors: Hayyat Umer , Shahid Muhammad , En Jonathan Lee Tian , Dutta Nalok , Khan Muhammad Usman
Published: February 2025

In recent years, there has been a widespread focus on utilizing bioenergy derived from forests as an effective and sustainable renewable energy alternative. The utilization of wood wastes and forest residues to generate heat and produce energy has gained significant importance. However, there are certain challenges associated with using these materials in their original form. Biomass pelletizing presents a promising solution by converting raw biomass into fuel pellets that possess high energy density. Furthermore, the resulting biochar plays a vital role in enhancing soil quality. This chapter delves into the process of manufacturing wood fuel pellets and explores their diverse applications across residential and industrial sectors. It also examines technologies for producing biochar from this waste, highlighting potential benefits such as carbon sequestration and soil enrichment they offer. Moreover, this chapter also discusses various heat generation technologies that can be used in conjunction with biomass pellet production.
El Río Magdalena (Colombia) como patrimonio de la humanidad en categoría de itinerarios culturales, aportes del proyecto Pacto de País
Authors: Rincón Cardona Fabio
Published: February 2025

Este artículo expone los avances del proyecto “Pacto del País por el Río Grande de la Magdalena”, el cual resalta la importancia de abordar el río como Itinerario Cultural, al considerar su valor simbólico, ambiental, histórico y cultural; brinda apoyo y propone acciones previas para la futura declaración como patrimonio mundial de la unesco en la categoría de itinerarios culturales, fundamentado principalmente en la apropiación social, cultural, la participación interinstitucional, conservación, protección, desarrollo sostenible del río y las comunidades. Analiza la problemática del río Magdalena, y evidencia cómo desde el proyecto se ha trabajado entendiendo el río como sujeto de derechos, el reconocimiento que ha tenido y sus declaratorias, tomando en cuenta el ods 6; además, expone y analiza la matriz dofa del Plan Maestro Fluvial realizado por arcadis el cual contiene información fundamental sobre el río. El proyecto busca no solo proteger y valorar el río como Itinerario Cultural, sino también promover el desarrollo sostenible en la región; abordar los desafíos del río mediante un enfoque colaborativo e interdisciplinario, al promover su sostenibilidad y valor cultural mientras fortalece la investigación y la cooperación entre entidades.
¿Por qué el bilingüismo en Colombia? Una revisión sistemática
Authors: Viana Astaiza Jaime Alejandro , Gómez Medina Carola
Published: February 2025

Colombia ha emprendido diversos procesos de enseñanza y aprendizaje de lenguas extranjeras con el objetivo de impulsar al país hacia una comunidad más competitiva y capaz de interactuar a nivel global. En este contexto, el Ministerio de Educación Nacional (MEN) promulgó en 2004 el Programa Nacional de Bilingüismo, como estrategia para integrar al país en las dinámicas de comunicación internacional. El presente estudio analiza el estado actual de esta política mediante una revisión sistemática, siguiendo las directrices del método PRISMA. Se seleccionaron diecinueve documentos relevantes para comprender los hallazgos de investigaciones previas sobre la política lingüística en Colombia. El análisis revela la influencia de la globalización en la política lingüística centrada en el inglés, excluyendo lenguas minoritarias; Colombia, a pesar de ser una nación multiétnica, favorece el inglés; los resultados en pruebas estandarizadas son bajos; y faltan estudios rigurosos sobre la política lingüística actual que incluyan las experiencias de los participantes.
Emergencja duszy. Andreasa Nordlandera odczytanie potencjalizmu św. Augustyna i kwestia stworzenia duszy ludzkiej w ewoluującym wszechświecie
Authors: Maziarka Tomasz
Published: February 2025

Artykuł podejmuje zagadnienie stworzenia duszy ludzkiej w kontekście ewolucji, przy zastosowaniu ram interpretacyjnych poglądów św. Augustyna, zaczerpniętych od Andreasa Nordlandera. Biskup Hippony opowiada się za stopniowym wyłanianiem się świata i bogactwa rzeczy z potencjalności, zawartych w materia informis i rationes seminales, stworzonych ex nihilo. Taka wizja rozwoju przyrody bardzo dobrze wpisuje się w ewolucyjny obraz świata, kreślony przez nauki przyrodnicze, który ujawnia emergencję nowych fenomenów na skutek tworzenia się coraz bardziej złożonych struktur. Szczegółowego rozpatrzenia domaga się stworzenie ludzkiej duszy. Klasyczne rozwiązanie Augustyna mówi, że na drodze przyrodniczego rozwoju mogło powstać jedynie ludzkie ciało, natomiast dusza została powołana do istnienia oddzielnym aktem, a następnie „wlana” w ciało. Z przyrodniczego punktu widzenia rozwiązanie to napotyka na pewne trudności. Okazuje się jednak, że narzędzia heurystyczne, których dostarcza Augustyn, pozwalają na uniknięcie tych problemów i możliwy jest do pomyślenia scenariusz, w którym cały człowiek z duszą i ciałem powstaje na drodze ewolucji. Rozwiązanie to wiąże się z przekroczeniem ram antropologii św. Augustyna, ale jest zupełnie spójne z jego ideą potencjalizmu. Ten bardziej radykalny potencjalizm niweluje napięcia wewnątrz antropologii Augustyna, a jednocześnie przez swą spójność z naukami przyrodniczymi stanowi cenny wkład w dialog między nauką a religią. 
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Zgłoszono: 15/03/2024. Zrecenzowano: 13/06/2024. Zaakceptowano do publikacji: 17/09/2024.
Spójność tezy o superweniencji z koncepcją pierwotności substancji duchowej oraz pozamaterialnego pochodzenia świadomości indywidualnej
Authors: Łagosz Marek
Published: February 2025

W artykule podejmuję próbę wykazania zgodności tezy o superweniencji z koncepcją pierwotności substancji duchowej oraz niematerialnego pochodzenia indywidualnej świadomości. Ujmując rzecz nieco szczegółowiej, staram się odpowiedzieć na pytanie: czy, założywszy superweniencję jednostkowej (indywidualnej) świadomości na tym, co fizyczne (materialne), można utrzymać tezę o jej pierwotności (ogólniej: o pierwotności ducha) wobec materii? Dochodzę do wniosku, że absolut ontyczny musi (może) być czystym duchem, który jest źródłem wszelkiej duchowości uwikłanej w ciało i materialnego podłoża, na którym się ona realizuje. Praca stanowi polemikę z naturalistycznymi koncepcjami świadomości.
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Zgłoszono: 5/02/2024. Zrecenzowano: 8/08/2024. Zaakceptowano do publikacji: 21/10/2024.
Eliminative Ontic Structural Realism and the Metaphysical Underdetermination Argument: A Critique
Authors: Luty Damian
Published: February 2025

In this paper I address the problem of justifying Steven French’s eliminative ontic structural realism by the metaphysical underdetermination argument. My main goal is to show that there are underlying strategies in the argument and that they are questionable. I provide arguments for this claim and conclude that while the metaphysical thesis of eliminative ontic structural realism is dismissible, French’s views can be characterized without it – at a very high price, however.
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Received: 23/04/2024. Reviewed: 7/10/2024. Accepted: 15/11/2024.
Konflikt wokół kwestii ekologicznych – zdynamizowanie ludzkiej podmiotowości czy preludium nieuchronnej zagłady? Perspektywa etyki odpowiedzialności globalnej
Authors: Ciążela Helena
Published: February 2025

Publikowana od 2018 roku seria raportów Intergovernmental Panel on Climate Change (IPCC) zradykalizowała oceny, dotyczące realności katastrofy klimatycznej, zagrażającej Ziemi – katastrofy, wywołanej przez rabunkową eksploatację zasobów paliw kopalnych. Wprowadziła nową jakość w obszar debaty publicznej i polityki klimatycznej. Efektem tego stały się podjęte przez Parlament Europejski szerokie regulacje prawne, służące powstrzymywaniu katastrofy, określone jako Zielony Ład. Regulacje te wywołały szereg napięć i konfliktów. W artykule podjęta została próba analizy skutków tych konfliktów dla dalszej walki z globalnym ociepleniem i zagrożeniem katastrofą klimatyczną. Analiza przebiegu i  prawdopodobnych skutków konfliktów pozwala na stwierdzenie, że odgrywają one destrukcyjną rolę dla dalszego rozwoju wydarzeń. Powodują wzrost dążenia do obrony zagrożonych interesów, a tym samym utrwalanie dotychczasowych podziałów. Czynnikiem wzmacniającym negatywne tendencje stała się wojna w Ukrainie, powodująca wzrost kosztów utrzymania w krajach Unii Europejskiej. Sumowanie się kosztów Zielonego Ładu i wojny powoduje wzrost niechęci do polityki ekologicznej, a jej przymusowy charakter rodzi pytania o efektywność i skuteczność.
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Zgłoszono: 30/04/2024. Zrecenzowano: 27/06/2024. Zaakceptowano do publikacji: 29/07/2024.
Diminazene Aceturate (DIZE) Ameliorates Hypertension and Induces Anxiolytic- and Antidepressant-Like Effects in TGR(Mren2)27
Authors: Costa Laura A. , Mourão Flávio A.G. , Alenina Natalia , Bader Michael , Campagnole-Santos Maria Jose , Kangussu Lucas M.
Published: February 2025

Introduction:

Diminazene aceturate (DIZE) was described as an angiotensin-converting
enzyme 2 (ACE2) activator. ACE2/Angiotensin-(1-7)/Mas receptor axis presents protective actions
on cardiovascular diseases and plays an important modulatory role in the neurobiology of
mood and anxiety disorders.

Objectives:

To evaluate the effects of chronic intracerebroventricular (ICV) treatment with DIZE
on blood pressure, anxiety- and depression-like behaviors in hypertensive transgenic (mRen2)27
rats (TGR).

Methods:

Male TGR and Sprague-Dawley rats (10-12 weeks old) were subjected to chronic ICV
infusion of DIZE (1.0 μg/h for 7 days). Blood pressure and heart rate were measured by tail
plethysmography and anxiety- and depression-like behaviors were evaluated through elevated
plus maze, marble burying and forced swim tests, respectively.

Results:

Treatment with DIZE induced a significant reduction in mean arterial pressure in both
TGR and SD rats. A decrease in heart rate was only observed in the hypertensive animals. Additionally,
treatment with DIZE attenuated the anxiety- and depression-like behaviors that were observed
in TGR.

Conclusion:

DIZE has central anti-hypertensive, anxiolytic, and anti-depressive effects.
Molecular and Biochemical Evidence of Edaravone's Impact on Dasatinib-induced AGS Cell Senescence: A Promising Strategy for Gastric Cancer Therapy
Authors: Rahimifard Mahban , Baeeri Maryam , Manavi Mohammad Amin , Khalid Madiha , Foroumadi Roham , Haghi-Aminjan Hamed , abdollahi Mohammad
Published: February 2025

Introduction:

Internal or external stress can induce cellular senescence,
which reduces cell division. These metabolically active cells contribute to medication resistance.
We examined the potential for edaravone (Eda) to cause apoptosis in dasatinib
(Das)-induced senescent gastric adenocarcinoma cells (AGS). Our goal was to develop a
new stomach cancer treatment.

Method:

All Eda doses evaluated were nontoxic to cells. Das decreased AGS cell survival
in a dose-dependent manner. The study found that Das (5-10 μM) and Eda (100 μM)
caused cell senescence in AGS cells. This was shown by increased β-galactosidase enzyme
activity and reactive oxygen species levels and decreased telomerase enzyme activity.
These are the biggest signs of aging.

Results:

This combination therapy also upregulated the expression of cell-senescence
genes p53, p16, p21, and p38. This resulted in increased expression of inflammation
genes such as TNF-α, IL-1β, and IL-6.

Conclusion:

The scratch assay showed that this combination medication down-regulated
the cell migration-regulating MMP2 gene. Both Das and Eda decreased AGS cell proliferation,
suggesting treatment with Eda may prevent metastasis.
Inflammation-driven Oncogenesis: Precision Medicine and Immunotherapeutic Strategies
Authors: Alkaraki Almuthanna , Aljabali Alaa A. A. , Obeid Mohammad A.
Published: February 2025

Cancer is one of the most important health burdens worldwide, affecting many people
and putting huge pressure on the healthcare system. There are multiple driving forces, and increasing
attention has been gained over the past two decades regarding chronic inflammation, which represents
a pivotal factor owing to its ability to establish or maintain an environment that is permissive
for tumor initiation, growth, and progression. This review details the interplay between inflammation
and cancer by highlighting how chronic inflammation fuels oncogenesis by promoting genetic
instability, immune evasion, and a setting rich in pro-tumorigenic signaling. This review explains
how various inflammatory mediators, including cytokines and transcription factors, can potentially
create tumor microenvironments by drawing on case studies and recent research data. Furthermore,
this article provides insights into the molecular mechanisms of Nuclear Factor Kappa B (NF-κB)-
regulated pathways and inflammasomes and provides essential molecular links between inflammation
and tumorigenesis. Furthermore, novel therapeutic approaches using nanotechnology and immunotherapy
are also discussed. Nanotechnology offers precise drug delivery with increased targeting
to tumor sites, whereas immunotherapy, including immune checkpoint inhibitors, attempts to
restore the functionality of the immune system to recognize and destroy cancer cells. Thus, a combination
of these approaches represents a promising new frontier in cancer treatment that addresses
both the inflammatory and immune dimensions of oncogenesis. This review highlights the importance
of integrating molecular insights into novel therapeutic strategies to address the dual challenges
associated with chronic inflammation and cancer. Their development could lead to significant
improvements in patient outcomes and reduce global cancer burden.
Application Value of A Clinical Radiomic Nomogram for Identifying Diabetic Nephropathy and Nondiabetic Renal Disease
Authors: Liu Xiaoling , Xiao Weihan , Qiao Jing , Qin Xiachuan
Published: February 2025

Objective:

An ultrasound-based radiomics Machine Learning Model (ML) was utilized to assess non-invasively the conditions of diabetic nephropathy and
non-diabetic renal disease in diabetic patients.

Methods:

A retrospective examination was conducted on 166 diabetic patients who had undergone renal biopsies guided by ultrasound, with the group
comprising 114 individuals diagnosed with diabetic nephropathy and 52 with non-diabetic renal disease. The participants were randomly divided
into the training set and the testing set (7:3). Following the extraction of radiomics features from the renal ultrasound images, a univariate analysis
was conducted, and the Least Absolute Shrinkage And Selection Operator (LASSO) algorithm was applied to select the most significant features.
Three ML algorithms were applied to construct the prediction models. Subsequently, the patients' clinical characteristics were evaluated through
both univariate and multivariate logistic regression analyses, which facilitated the development of a clinical model, following a clinical radiomics
model was formulated, integrating the radiomics scores (Radscore), along with the independent clinical variables identified through the screening
process. The diagnostic performance of the three models constructed was evaluated using the receiver operating characteristic (ROC) curve
analysis.

Results:

Among the three radiomics ML models, the logistic regression (LR) model achieved the best performance, with the area under the curve (AUC)
values of 0.872 (95%CI, 0.800-0.944) and 0.836 (95%CI, 0.716-0.957) for the training set and the testing set, respectively. The decision curve
analysis (DCA) verified the clinical practicability of the ML model. Within the same testing set, the AUC of the clinical model was 0.761 (95%CI,
0.606-0.916). The nomogram model based on clinical features plus Radscore showed the best discrimination, with an AUC value of 0.881 (95%CI,
0.779-0.982), which was better than that of the single clinical model and the radiomics model.

Conclusion:

The ML model of radiomics based on ultrasound images has potential value in the non-invasive differential diagnosis of patients with diabetic
nephropathy. The nomogram constructed based on rad score and clinical features could effectively distinguish DN from NDRD.
Recurrent Missense Driver STAT5B N642H Mutation in Children Transiting into Adolescence, with Acute Lymphoid Leukemia and its In silico Inhibition
Authors: Yasmin Rehana , Abbasi Rashda , Gohar Tajdar Jahangir , Hina  , Ahmad Nafees , Malik Sajid
Published: February 2025

Background:

The occurrence of gain of function mutations in STAT5B has been associated to survival,
and drug resistance in Leukemia. In silico screening of compounds having inhibitory potential towards mutated
proteins, can be helpful in the development of specific inhibitors.

Objective:

This study was designed to screen selected JAK-STAT mutations in leukemia patients and virtual exploration
of molecular interaction of potential inhibitors with their mutated products.

Methods:

In total 276 patients were randomly recruited for this study. Demographic and clinical data were summarized.
The genetic status of JAK1V623A, JAK2 S473 and STAT5BN642H were screened through allele specific PCR.
In-silico analysis was performed on wild type and mutant protein sequences retrieved from Protein databank. The
ligands and protein were prepared through standard protocols, and docking was performed through Auto Dock
Vina 1.2.0.

Results:

Acute lymphoblastic leukemia comprises 70% of the total patients. Male to female ratio was 3:1. All the
patients were homozygous for JAK1V623A, JAK2 S473 major allele. However, 6 patients (5 male, 1 female) with
ALL were STAT5BN642H+. The molecular docking of the ligands to wild type and STAT5BN642H+revealed that AC-
4-130, Pimozide, Indirubin and Stafib-2 have higher but differential docking affinities for SH2-domain of both
normal and mutated STAT5B. However, AC-4-130 has a higher affinity for wild type and Stafib-2 has stable
molecular interaction with STAT5BN642H+.

Conclusion:

The aggressive form of pediatric leukemia, carrying STAT5BN642H+ mutation is identified in the
studied population. It is predicted that AC-14-30 and stafib-2 have potential for inhibition of constitutively active
STAT5B if optimized for use in combination therapy.
The Kinesin Eg5 Inhibitor K858 Enhances Radiosensitivity in Esophageal Squamous Cell Carcinoma and Affects the Expression of Epithelial-mesenchymal Transition Related Markers: In vitro and In vivo Studies
Authors: Liu Ruixue , Yu Zhijun , Shen Wenbin , Zhu Shuchai
Published: February 2025

Background:

Radioresistance is the primary cause of treatment failure in esophageal squamous cell
carcinoma, emphasizing the importance of identifying effective radiosensitizers.

Objectives:

This study aimed to explore the effects and potential mechanisms of Eg5 inhibitor K858 on the radiosensitivity
of esophageal squamous cell carcinoma TE-1 and KYSE150 cell lines, as well as xenografts (TE-1
cells).

Methods:

Cellular function was assessed using CCK8, wound healing, and transwell invasion assays. Radiosensitivity
parameters were derived from colony formation assays. Cell apoptosis and cell cycle were assessed using
flow cytometry, whereas protein expression levels were detected using western blotting and immunohistochemistry.
The xenograft model was used to observe the growth of tumors.

Results:

K858 inhibited the malignant functions of TE-1 and KYSE150 cell lines. Radiosensitivity parameters
were reduced after K858 treatment. The combination of K858 and irradiation markedly suppressed cell proliferation,
induced apoptosis, and stimulated cell cycle arrest during the irradiation-sensitive phase. Additionally,
K858, combined with irradiation, significantly increased the expression of the epithelial-mesenchymal transition
marker E-cadherin and decreased the expression of N-cadherin, vimentin, MMP2, and MMP9. K858, combined
with irradiation, significantly inhibited tumor growth in xenograft models.

Conclusion:

K858 enhanced the radiosensitivity of esophageal squamous cell carcinoma and affected the expression
of epithelial-mesenchymal transition-related markers.
Experimental and DEM study of flow behaviour of microcrystalline cellulose powders mix from conical silos
Authors: BARIK Santosh K.
Published: February 2025

Abstract. Hoppers and silos play an essential role in industries for the transportation and storage of materials. In this work, we examine both experimental and discrete element method (DEM) to study the microcrystalline cellulose (MCC) powder flow from two conical silos. In the conical silos with 60° and 80° angles, we conducted experiments on bidisperse and tridisperse MCC particles. Experiments were conducted by neglecting the effect of air. This study investigates the impact of mixture composition on flow rates, average particle velocity, and segregation. The numerical analysis is performed by DEM and is validated with the experimental results. The DEM parameters were taken from the previous literature. The results analyzed include mass discharge rate (MFR), flow dynamics (velocity profile across axial directions), and particle segregation. The results indicate that the mixture's fine percentage and number of components significantly determine its flow behavior. The DEM MFR findings were similar to those obtained from the experiments. The DEM MFR findings were more accurate for ternary mixtures than those of the binary mixtures. The fines average velocity is more than that of larger particles from the discharge initiation till around half of the material discharges. From this DEM study, it is observed that particle segregation takes place for mixtures comprising varying particle sizes in a conical silo. The effect of segregation is more when the mixture contains fewer fines. The intensity of segregation computed by DEM is higher in the case of binary mixtures than in ternary mixtures. The extent of segregation was observed more in the 60° silo than in the 80° silo. The segregation can be reduced by increasing the fine mass fraction in a mix and reducing the particle size difference. The DEM method can help obtain data where experiment findings are complex. The DEM software used named as LIGGGHTS has the advantage of being an open-source software. Particle systems with more than 1 × 108 particles can require computational time for weeks on a supercomputer.
LE CONCEPT DU SENTIMENT DANS LE PROCESSUS CRÉATIF SELON THÉODORE DE WYZEWA : DE KANT À LÉON TOLSTOÏ ET RICHARD WAGNER
Authors: Rovenko Elena
Published: February 2025

L’article examine les origines des points de vue esthétiques de Théodore de Wyzewa, critique et traducteur français, et brillant représentant de l’idéalisme subjectif. L’accent est mis sur l’influence des idées de Kant et de Tolstoï sur le concept du sentiment dans l’interprétation de Wyzewa.
DE LA MOTIVATION ET DE L’ÉMOTION VERS L’ACTION : UNE PISTE DE TRAVAIL EN CLASSE DE FLE
Authors: Simović Vesna , Filipović Nataša
Published: February 2025

Parmi les facteurs de réussite scolaire, la motivation est souvent considérée comme dominante. Elle initie, renforce, maintient et oriente l'activité de l'apprenant vers l'atteinte des objectifs fixés. Les recherches dans ce domaine ont montré que les apprenants qui ressentent du plaisir et de la joie en apprenant, qui apprennent par désir d’apprendre ou par défi personnel, se souviennent plus longtemps et de manière plus approfondie des contenus adoptés, les relient mieux et les appliquent plus facilement. En revanche, ceux qui apprennent parce qu'ils le doivent ou à cause de la réalisation d'un objectif oublient plus rapidement ce qu'ils ont appris et ont plus de mal à l’appliquer dans la pratique. On considère également que les meilleurs résultats en apprentissage sont obtenus en accomplissant des tâches authentiques liées à des situations réelles dans lesquelles l'apprenant se retrouvera en dehors de la classe.Dans notre article, nous donnons d'abord le cadre théorique sur lequel s'appuie notre projet, puis l’atelier de traduction conçu pour motiver les apprenants à apprendre le français et à travailler en autonomie grâce aux tâches authentiques et un document-support stimulant proposés. Finalement, nous présentons le bilan du projet concernant sa qualité motivationnelle jugée par les étudiants. L'objectif du projet est de motiver les apprenants à travers l'utilisation de supports et d'activités qui représentent un défi et apportent une satisfaction au travail.
LA LITTÉRATURE FRANÇAISE DU XVIIE SIÈCLE TRADUITE EN SERBE : PROSE
Authors: Vlaškalić Nebojša , Đurin Tatjana
Published: February 2025

Dans le présent travail, nous nous proposons d’analyser les traductions serbes des œuvres de la littérature française du XVIIe siècle. Le corpus comprend les œuvres en prose de nombreux auteurs français du XVIIe siècle (Fénelon, La Bruyère, Descartes, Pascal et d’autres). Puisqu’il s’agit d’une recherche rétrospective, le cadre théorique de notre étude est le paradigme historico-descriptif de la traductologie (descriptive translation studies). Nous présenterons les résultats de la première phase d’une telle recherche – celle de recueil de données, effectuée à l’aide du système COBISS, système de catalogage collectif virtuel des bibliothèques de la Serbie (https://sr.cobiss.net/). Nous avons également utilisé les données recueillies par Ljiljana Glumac-Tomović (1991), Nenad Krstić (1999) et Biljana Ristić (2016), ainsi que l’ouvrage de synthèse publié en 2019 (Histoire de la traduction littéraire en Europe médiane des origines à 1989). Notre recherche est basée sur la théorie du polysystème proposée par Itamar Even-Zohar dans les années 70 (Even-Zohar 1978). Une telle analyse traductologique permet d’identifier les normes de traduction (préliminaires et opérationnelles) (Toury 1995) adoptées par les traducteurs serbes et parfois expliquées dans le paratexte (préfaces, postfaces, notes), ainsi que d’établir la position (centrale ou périphérique) de la littérature française du XVIIe siècle dans le polysystème littéraire serbe. Selon les postulats de la théorie du polysystème, les traductions ne sont pas analysées individuellement, afin de déterminer les correspondances linguistiques et stylistiques (le degré d’équivalence), mais plutôt prises dans leur ensemble, dans le but de déterminer la place et le rôle de la littérature française du XVIIe siècle, en tant que littérature traduite, dans le polysystème littéraire serbe.
PROPOSITIONS RELATIVES EN FRANÇAIS SCIENTIFIQUE
Authors: Mirić Milica , Samardžija Tatjana
Published: February 2025

La subordonnée relative adjointe permet de construire des syntagmes à la fois complexes et concis (Kocourek 1991, 79-80). Elles constituent ainsi un outil caractéristique de la description scientifique (Charaudeau 1992). Deux fois plus fréquentes en moyenne dans notre sous-corpus des sciences humaines et sociales que dans le sous-corpus médical, les relatives montrent d’importantes variations en nombre selon le relatif en question. Le relatif dont, d’une fréquence égale dans les deux sous-corpus, se distingue par la prédominance de sa fonction syntaxique de complément de nom au sein de la relative, ce à quoi correspond la progression textuelle à thème dérivé (Daneš 1974; Combettes 1983). Cette fonction de dont est suivie de loin du dont complément d’objet indirect, correspondant à la progression linéaire.
LE MARQUEUR DISCURSIF ALORS DANS LES CORPUS ORAUX D’APPRENANTS DE FRANÇAIS LANGUE ÉTRANGÈRE
Authors: Valetopoulos Freiderikos
Published: February 2025

L’objectif de cet article est de proposer une étude du marqueur discursif alors dans les productions orales argumentatives d’apprenants avancés de français langue étrangère en milieu exolingue. Ce marqueur sera également étudié dans un corpus de locuteurs natifs qui ont réalisé la même tâche. Nous nous concentrerons sur l’utilisation de alors, car il est présenté dans les références bibliographiques qui portent sur le français comme étant le marqueur le plus fréquent, qui assume plusieurs fonctions. Le corpus a été collecté dans le cadre d'un projet portant sur l'acquisition du français langue étrangère par des apprenants en milieu exolingue.
AUTOÉVALUATION : UN DÉFI POUR LES ENSEIGNANTS DES LANGUES ÉTRANGÈRES
Authors: Sakellari Natalia
Published: February 2025

Le droit à l’éducation est le droit de toute personne d’accéder à une instruction de qualité. Cette instruction de qualité constitue une priorité pour tous les États-membres de l’Union Européenne. Dans ce cadre d’amélioration et d’optimisation des processus de l’enseignement-apprentissage, il s’avère que l’autoévaluation des enseignants est un outil indispensable et inestimable en même temps. Dans le présent article, nous présenterons un modèle d’autoévaluation pour les enseignants des langues étrangères. Les critères du modèle s’appuient sur les critères du Modèle d’Excellence de la Fondation Européenne pour la Gestion de la Qualité (désormais siglé EFQM), adaptés à l’éducation en Grèce en tenant compte de tous les paramètres qui peuvent influencer l’enseignement-apprentissage d’une langue étrangère en milieu scolaire. Dans un premier temps, nous exposerons l’étude menée auprès des enseignants des langues étrangères des écoles publiques grecques. Par la suite, nous démontrerons – au travers des résultats obtenus – comment ce modèle peut contribuer à l’amélioration et à l’optimisation de la qualité de l’enseignement des langues étrangères et comment l’adoption et l’application du modèle sur le tas peut devenir efficace pour l’apprentissage des langues étrangères.
LA SUBTILE FRONTIÈRE ENTRE POLYSÉMIE ET HOMONYMIE
Authors: Miljković Ivana
Published: February 2025

L’article propose une étude comparative de l’homonymie et de la polysémie. Nous présentons ces deux concepts dans le but d’en mettre en évidence les différences afin de savoir catégoriser les lexèmes, c’est-à-dire savoir distinguer ceux qui relèvent de chacun des deux cadres. À ce titre nous étudions en particulier le lexème cher, pour lequel la question de la classification se pose.  La polysémie se caractérise par des sèmes partagés entre les différents sens d’un même lexème, ce qui n’est pas le cas dans le cadre de l’homonymie. Notre méthode, descriptive et contrastive, consiste à associer à chaque lexème étudié des lexèmes ayant des sèmes en commun, puis à examiner les sèmes partagés et à conclure sur la nature homonymique ou polysémique de chaque cas.  Sur le plan formel, nous explorons certaines théories contemporaines. Cependant, nous ne négligeons pas la diachronie et l’étymologie, qui sont pertinentes pour notre sujet d’étude.Le mot cher, en français, peut se comprendre de deux façons : soit pour désigner coûteux soit pour désigner aimé. Est-on face à un lexème polysème ou à deux lexèmes homonymes ? Nous soutenons la première hypothèse et l’argumentons, sur la base aussi de l’étymologie et de l’étude de différents dictionnaires.
LA MÉMOIRE ET LA PERCEPTION DU TEMPS DANS À LA RECHERCHE DU TEMPS PERDU DE MARCEL PROUST
Authors: Gjorgjievska Eva
Published: February 2025

L’article vise à contribuer à l’interprétation de la temporalité chez Proust, à travers la mémoire sensorielle, sachant que la critique proustienne réduisait autrefois l’œuvre soit à un roman de souvenirs, soit à un roman du moment présent. Cela veut dire qu’outre les parties dans lesquelles Proust théorise sur la mémoire et sur le vécu, il y a d’autres parties du roman qui décrivent le temps, sans que le Narrateur lui-même n’en fasse une théorie. Notre objectif est d’en déduire plusieurs phénomènes du temps qui enrichiraient la perception de ce que représente le temps dans ce roman. Pour Proust, les personnages et les cathédrales portent aussi le temps, et les rêves et les sensations créent de nouvelles dimensions du temps. Nous allons examiner toutes les manières d’interpréter ce que le temps représente pour Proust et comment ce temps prend une dimension esthétique.
L’EXPRESSION ORALE ET LA COMPÉTENCE INTERCULTURELLE EN CLASSE DE FLE
Authors: Ignjatović Nataša
Published: February 2025

Les thèmes interculturels et transculturels qui permettent à l’apprenant de relativiser sa vision du monde, de dépasser son ethnocentrisme afin de mieux comprendre lʼAutre peuvent être perçus comme motivants et déclencheurs de parole. Le travail en classe avec ces thèmes a un double objectif : favoriser lʼexpression orale en classe et développer lʼesprit critique car il sʼagit des thèmes qui peuvent éveiller lʼintérêt et la curiosité et inciter à la prise de parole. Étant donné que les manuels sont une ressource largement utilisée en classe nous pensons qu’il serait bien de sélectionner quelques documents se trouvant dans les manuels contemporains de FLE qui pourraient déclencher chez l’apprenant la prise de parole et sa réflexion sous l’optique de la dimension interculturelle. Le but de ce travail serait de mettre en valeur les documents choisis imprégnés de la dimension interculturelle se trouvant dans les manuels contemporains de FLE du niveau B1 (Cosmopolite 3, Alter Ego + 3, Latitudes 3 et Belleville 3) pour voir de quelle manière ils pourraient être exploités en classe pour faire développer la réflexion critique et interculturelle et l’expression orale. Nous avons donc sélectionné quelques documents à visée interculturelle/transculturelle qui pourraient déclencher la prise de parole et inciter les apprenants à réagir et/ou à interagir.
ATTITUDES ON GRADING OF PRE-SERVICE AND IN-SERVICE PHYSICAL EDUCATION TEACHERS
Authors: Kretschmann Rolf
Published: February 2025

Assessing and grading students’ performance in class is an essential part of teaching as a profession. Compared to other classroom-based subjects, Physical Education (PE) teachers usually handle grading practices in the motor learning domain and in a gym-based environment (Rink, 2013). Pre-service and in-service teachers may have different views on handling grading in PE according to differences in teaching experience, and theoretical and practical knowledge (Alkharusi, Kazem, & Al-Musawai, 2011; Schempp et al., 1998). This study aims to investigate in-service PE teachers’ (ISPET) perspectives of teaching practices in grading and compare them to the respective pre-service PE teachers’ (PSPET) perspectives. To find a common set of teaching practices for grading in PE that fits knowledge and experience scopes of both in-service and pre-service PE teachers, essential aspects of grading were extracted out of systematic research on PE teachers’ stress factors (König, 2004). Communicative and pragmatic validity of selected items were ensured by group discussion with selected pre-service and in-service PE teachers. 132 pre-service PE teachers and 134 in-service PE teachers were surveyed using a questionnaire consisting of personal data and previously developed items on teaching practices in grading. Results showed statistically significant differences in slightly more than a half of the respective attitudes on grading practices (e.g., “I assess and grade student performance frequently, because students learn well under pressure.”). ANOVA showed significant differences regarding study/teaching experience in both groups in regard to some attitudes on grading. PE teacher education programs and PE teachers’ continuing professional development may emphasize the change in teaching practices in grading to increase awareness.
CAN INTER-LIMB ASYMMETRIES IN MUSCLE STRENGTH BE RELIABLY ASSESSED? A PRELIMINARY STUDY ON TEST-RETEST RELIABILITY AND THE EFFECT OF TESTING POSITION ON GRIP STRENGTH MEASUREMENTS
Authors: Vidović Milica , Pešič Miha , Nedović Nenad , Jovanović Stevan , Vujičić Danilo , Kozinc Žiga
Published: February 2025

This preliminary study investigates the test-retest reliability of assessing inter-limb asymmetries using grip strength measurements and examines the effect of testing positions (sitting vs. standing) on these assessments. The study involved ten healthy adults who participated in two testing sessions, where grip strength was measured using a Jamar dynamometer in both sitting and standing positions. The reliability of these measurements was analyzed using intraclass correlation coefficients (ICC) and other statistical measures, such as the typical error (TE) and coefficient of variation (CV). The results demonstrated good to excellent reliability for grip strength measurements in both sitting and standing positions, with ICC values ranging from 0.96 to 0.98. However, the reliability of asymmetry assessments showed greater variability, particularly in the sitting position, where the ICC for asymmetry was lower (0.82) compared to the standing position (0.91). The observed differences in reliability suggest that factors such as body posture, joint angles, and hand-grip positioning might significantly influence the outcomes of inter-limb asymmetry assessments. Moreover, the study found that asymmetry measurements varied between sessions, particularly in the sitting position, indicating potential learning effects or motivational differences. These findings underscore the importance of standardized testing protocols and suggest that a single testing procedure may not be sufficient to reliably assess inter-limb asymmetries. Further research with larger sample sizes and more controlled conditions is recommended to validate these preliminary findings and to explore the influence of different testing positions on the reliability of asymmetry assessments.