bluuebunny/crossref_metadata_2025 huggingface dataset:
A Paisagem de Vila Velha: o desafio da conservação do patrimônio cultural/natural da APA de Santa Cruz, Itamaracá (PE)
Authors: Ferreira Pedro Henrique Valença , Silva Jônatas Souza Medeiros da , Bezerra Onilda Gomes
Published: December 2019

O presente trabalho tem como objetivo compreender a paisagem de Vila Velha, situada no município da Ilha de Itamaracá, Pernambuco, onde ainda hoje se descobrem sítios arqueológicos que datam desde a colonização da costa brasileira, no século XVI. O povoado de Vila Velha é tombado em instância estadual pela Fundação do Patrimônio Histórico e Artístico de Pernambuco (FUNDARPE), e compreende-se dentro dos limites da APA de Santa Cruz, Unidade de Conservação da Natureza do Estado de Pernambuco, daí serem analisados de forma conjunta. Neste artigo, busca-se entender como se encontra o povoado de Vila Velha quanto a sua conservação, já que se insere numa sobreposição de proteção institucioanal em dois campos distintos do patrimônio, de modo a buscar soluções para enfrentar o desafio que é a conservação integrada do patrimônio cultural e natural. Objetiva-se ainda caracterizar seus atributos patrimoniais, que contribuem para a fundamentação do processo de reconhecimento oficial desse patrimônio natural e cultural. Como resultado, tem-se o conhecimento patrimonial do bem que, consequentemente, serve para embasar a construção de instrumentos operacionais voltados à gestão da conservação integrada do sítio.

PALAVRAS-CHAVE: Conservação da Natureza. Patrimônio Cultural/Natural. Gestão da Conservação.
A cultura da inclusão social no território da universidade: um olhar sobre a acessibilidade a partir de uma perspectiva da indissociabilidade entre o ensino, pesquisa e extensão
Authors: Rosa Cleyton Luiz da Silva , Braida Frederico , Cobucci Natália
Published: December 2019

O presente artigo tem como objetivo discutir os resultados do projeto de extensão “Diretrizes para projetos de Acessibilidade no Interior dos edifícios da Universidade Federal de Juiz de Fora, financiado pela Pró-reitoria de Extensão da própria universidade. O projeto, iniciado em 2015, foi constituído por uma equipe interdisciplinar, contando com a participação de professores e alunos das Faculdades de Arquitetura e Urbanismo e de Engenharia e do Instituto de Artes e Design. O objetivo das ações era contribuir com diretrizes para o território da universidade e, partindo de uma perspectiva da indissociabilidade entre ensino-pesquisa-extensão, sensibilizar os estudantes para as agendas da acessibilidade no ambiente construído com vistas ao fomento da cultura da inclusão social. As ações priorizaram o envolvimento de diversos agentes — instituições de pesquisas, comunidade, associações, representações da administração municipal — como um caminho para a construção do conhecimento por meio da extensão universitária.
Palavras-chave: Acessibilidade; Inclusão social; Extensão universitária; Universidade; Cultura.
Self-Perception: A view into the mind of Self-Imaging v1
Authors: Duval Hunter
Published: December 2019

When a person looks into a mirror, three reflections appear the reflection that only they see, the reflection that everyone else sees, and the reflection that is truly there. This is due to a mental phenomenon called self-perception, or the way a person views themself, whether it be true or false. A study was conducted by Hunter Duval, to determine the relationship between demographic information (i.e. Age, Race, Etc) and Self-Perception of individuals. The website, SurveyMonkey was used. 71 individuals from the social media platform, Reddit, and a local high school were interviewed regarding their Gender, Sexual Orientation, Race, and Perception. The study concluded that 51.62% of males, 64.86% of females, and 33.33% of other genders perceive themselves as unattractive, with females having the majority. The study also found that individuals who are part of the LGBT minority have a higher chance of perceiving themselves as unattractive than that of heterosexual, with Pansexual taking the majority. According to this data, oppressed populations and minorities seem to have a higher chance of feeling unattractive. This is likely because they are, as aforementioned, oppressed. Oppressed populations, such as those in the LGBT community, are forced to look down upon themselves by other peoples, thus causing their self-image to downgrade. Overall, minority populations are more likely to have a poorer self image than that of the majority.
6. Sınıf Bitki Ve Hayvanlarda Üreme, Büyüme Ve Gelişme Ünitesinin Öğretiminde Oyun Temelli Öğrenmenin Akademik Başarı Ve Tutum Üzerine Etkisi
Authors: SERDAROĞLU Cahide , GÜNEŞ Munise Handan
Published: December 2019

Bu araştırmanın amacı, oyun temelli öğrenmenin İlköğretim 6. sınıf Fen
Bilimleri dersi “Bitki ve Hayvanlarda Üreme, Büyüme ve Gelişme” ünitesinde
öğrencilerin akademik başarılarına ve derse yönelik tutumlarına etkisinin
incelenmesidir. Araştırmada ön test ve son teste dayalı yarı deneysel model
kullanılmıştır. Uygulamalar Orta Karadeniz
Bölgesindeki bir ilde yer alan devlet okulunda gerçekleştirilmiştir.
Araştırmanın çalışma grubu, 6.sınıfta öğrenim gören, deney grubu 20 kişi,
kontrol grubu 20 kişi olmak üzere toplam 40 öğrenciden oluşmaktadır. Bu
deneysel çalışma 12 ders saati süreyle yapılmıştır. Araştırma
sürecinde deney grubunda, mevcut programdaki kazanımlar doğrultusunda
hazırlanmış etkinlikler ve bu etkinliklere ek olarak araştırmacı tarafından
hazırlanan eğitsel oyun (tabu) kullanılırken, kontrol grubunda ise sadece
mevcut programdaki kazanımlara göre hazırlanan etkinlikler kullanılmıştır.
Çalışmada veri
toplama aracı olarak, “Fen Bilimleri Akademik Başarı Testi” ve “Fen Bilimleri Tutum
Ölçeği” kullanılmıştır. Elde edilen
veriler SPSS paket programı kullanılarak analiz edilmiştir. Verilerin analizi
sonucunda deney ve kontrol grubundaki öğrencilerin üniteye ilişkin akademik
başarıları ve Fen Bilimleri dersine yönelik tutumları arasında deney grubu
lehine anlamlı bir farklılık olduğu belirlenmiştir. Başka bir ifadeyle,
araştırmanın sonucuna göre eğitsel oyunla işlenen dersin öğrencilerinin
akademik başarılarının arttığı ve derse karşı tutumlarının da olumlu yönde
değiştiği görülmüştür. Dolayısıyla oyun temelli öğrenmenin diğer derslerde de
aktif bir şekilde kullanılması halinde öğrencilerin severek ve eğlenerek
öğrenmeleri sağlanabilir.
Experience in organizing psychological and pedagogical support to families raising children with ASD in the resource center "Nadezhda" of Volzhsky town
Authors: Voloshchuk O.V. , Karpova S.A. , Kazachkova E.V.
Published: December 2019

High-quality psychological and pedagogical support of a child is impossible without work with the family. The process of organizing of psychological and pedagogical support for families raising children with autism spectrum disorders in the resource center of the Regional Rehabilitation Center for Disabled Children "Nadezhda" in Volzhsky, Volgograd Region is described. The process of psychological and pedagogical support of families includes: diagnostics, informational support, teaching parents of competencies in raising and educating of children, involving parents in everyday correctional and development process, leisure activities. The role of interaction between specialists and parents, as well as role of the “School of Effective Parenting”, held in the “Nadezhda” Center emphasized in improving the quality of life of the family.
On the Book of Viсtor Kagan "Autism in Children", 2nd Edition, Supplemented
Authors: Iovchuk N. , Severniy A.
Published: December 2019

First published in 1981 and actual until nowadays, the book of Victor Kagan “Autism in Children” reprinted at “Smysl” Publishing House. Based on the vast literature, presented edition of the book describes the history of the development of the problem of autism since the beginning of the 20th century. Author formulates owns’ definition of autism, describes the clinical picture of childhood autism, as well as autism as a psychopathological nonspecific syndrome in the schizophrenia, schizoid psychopathy and paraautistic reactions. The author dwells in detail on the identification of differential diagnostic criteria, treatment and psychotherapy of autism. The book includes a chapter on the epidemiology of childhood autism, the reasons for the dramatic increase in autism indicators, among which the first place is not clinical criteria, but socio-financial benefits. Fundamental papers of L. Kanner and G. Asperger are at the end of the monograph.
The Efficiency of Animal-Assisted Therapy in Cognitive Behavioral Therapy: Psychotherapeutic Cases
Authors: Nikolskaya A.V. , Kostrigin A.A.
Published: December 2019

We discuss a rather new approach for the Russian psychotherapeutic practice — animal-assisted therapy. Russian scientific and psychotherapeutic literature lacks scientific studies that comprehensively consider the effectiveness of animal-assisted therapy (both positively and negatively), its use in cognitive behavioral therapy (CBT) and analyze in detail the researchers’ own experience of using animal therapy with a description of specific cases. Hence we discuss the key characteristics of animal-assisted therapy, describe the procedure of registering an animal for participation in therapy, analyze the results of using animal-assisted therapy for various psychotherapeutic and psychocorrectional problems, and substantiate the efficiency of animal-assisted therapy within CBT and its catalytic role in therapeutic processes. We describe the experience of using animal-assisted therapy as part of CBT. Using the example of two thematic cases that illustrate various goals and conditions, the structure and relevance of the inclusion of an animal in CBT depending on the client’s problem are considered, and methods of using an animal relevant to the client’s problem and psychotherapeutic goals are presented.
Assessment of Life Competencies in Elementary School Students
Authors: Davydova E.Y. , Sorokin A.B.
Published: December 2019

The paper describes a method of assessing life competencies in elementary school students The new pragmatic and system-based standards in education dictate the relevance of the development of instruments that assess life competencies.According to the activity-focused educational standard, the competencies are considered as a complex of the child’s regulation abilities, the ability to apply skills under specific conditions, and efficient social interaction.The proposed innovative method of assessing life competencies is based on the following principles: the assessment is carried while observing the child in a typical school situation; there are 5 levels of competency development ranging from the independent application of basic skills in routine situations to internally motivated creative activity; the revealed deficits are categorized according to the areas of mental functioning; multidimensional scaling enables determination of competency levels, their application fields, and deficit areas, providing insight into possible causes of learning disabilities.This method can be used by teachers and in all general and special education populations including children with autism spectrum disorders.The assessment outcomes can be applied in exploring the specifics of life competencies as well as in optimizing the learning and developmental processes within the framework of individual approach.
Interrelation of Psychological Features of Students and Their Willingness for Volunteer Activity
Authors: Raskhodchikova M.N. , Sachkova M.Y.
Published: December 2019

The paper discusses areas of research of volunteering and the determinants of willingness for volunteer activities in young people.We present outcomes of an empirical study of psychological characteristics both in students who are willing to volunteer and in those who are not.The study involved 105 second- and third-year students of psychology (59%) and management (41%) departments of two universities in Moscow (Russian Presidential Academy of National Economy and Public Administration, Moscow State University of Psychology and Education).The subjects were aged 19-22 years, with an average age of 19,8 years; 76% were females.The following techniques were used in the study: the altruism questionnaire (by O.F.Potemkina), the social empathy measure (by A.Mehrabian and N.Epstein, Russian adaptation by Yu.M.Orlov and Yu.N.Emelyanov), and the questionnaire of volunteer willingness developed specially for the study.The results of the study showed that there were significant differences in the willingness to volunteer and in the level of empathy and altruism among psychology students and manager students.The paper discusses the relationship between altruism, empathy indicators and willingness to participate in volunteer.
Actividad física y su relación con el sobrepeso y obesidad en docentes de la Universidad Nacional del Altiplano Puno 2017
Authors: Flores Paredes Alcides , Pino Vanegas Yoni Martín , Villamar Barriga Miguel Óscar
Published: December 2019

La práctica de la actividad física en la actualidad se hace necesaria por los múltiples beneficios que brinda al organismo. Los docentes de la Universidad Nacional del Altiplano por sus diferentes responsabilidades y escasa práctica en estilos de vida saludables son propensos a desarrollar el sobrepeso y la obesidad. El objetivo de la investigación fue conocer el nivel de actividad física y su relación con el sobrepeso y obesidad en docentes. La investigación utilizó el método científico, el tipo de investigación es básica, con diseño descriptivo correlacional con una población de 950 docentes y con una muestra de tipo no probabilística de 316 docentes (178 varones y 138 mujeres), con promedio de edad de 47.48 ± 9,92, la técnica utilizada fue la observación y el instrumento utilizado el cuestionario de actividad física y la aplicación de las mediciones antropométricas (estatura y peso). Resultados el 76.65% de docentes tienen un nivel de actividad física moderado, el 63% bajo y el 52.63% alto; así mismo el 68.02% se ubican en la escala sobrepeso, el 42.86% con obesidad y el 12.50% normal, en la variable sexo el 62.32% de mujeres se ubican en la escala sobrepeso, el 76.40% de varones en la escala sobrepeso. En conclusión, existe mayor prevalencia de sobrepeso y obesidad en docentes varones, en comparación con las mujeres. Se hace necesario implementar programas de intervención de salud integral en los docentes con base a la práctica de actividad física y alimentación saludable.
Autoconfianza y su relación con el rendimiento, procedencia, logros y edad en jugadoras de voleibol peruanas en categoría de formación
Authors: Mamani Ramos Angel Anibal , Huamaní Arredondo Freddy Jesús , Cabrejos Ramos Juan Carlos , Lava Gálvez Jhonny Jesús , Arce Roncal Daniela Lucía , Mora Santiago Rubén José , Quisocala Mamani Jorge Alberto , Torres Cruz Fred , Lipa Tudela Luzbeth , Fuentes López José Damián
Published: December 2019

El objetivo de este estudio fue determinar la relación de la autoconfianza con el rendimiento, procedencia, logros y edad en voleibolistas peruanas en categoría de formación. El estudio es de naturaleza no experimental, transeccional correlacional. Se estudió a 86 voleibolistas, de edades entre 12 y 16 años (M=15.59-DT=0.74), a quienes se les aplicó el inventario de confianza deportiva (reproductividad de .992). Los resultados demuestran que existe una correlación positiva, estadísticamente significativa, entre falta de confianza y rendimiento (r = .310; p < .01), falta de confianza y procedencia (r = .280; p < .01); confianza y edad (r = .244; p < .05); exceso de confianza y logros (r = .235; p < .05); nivel de autoconfianza y edad (r = .236; p < .05). Por otro, que existe una correlación negativa, también estadísticamente significativa, entre confianza y procedencia (r = -.342; p < .01); exceso de confianza y rendimiento (r = -.399; p < .01); nivel de autoconfianza y procedencia (r = -.387; p < .01). Se concluye que la autoconfianza en gran medida se asocia con el rendimiento deportivo, región geográfica de donde provienen y edad que presentan las voleibolistas, excepto con los logros deportivos obtenidos en categoría de formación.
Condición física, percepción subjetiva del esfuerzo y rendimiento académico en educación primaria
Authors: Ramírez Rubio Víctor , González Emilio Villa , Ruiz Yahira Barranco
Published: December 2019

Existen estudios que han conseguido establecer una relación entre el rendimiento cognitivo y académico de los alumnos y sus niveles de condición física. Los objetivos de esta investigación son estudiar la correlación existente entre el nivel de condición física y la composición corporal con el rendimiento académico, así como analizar la correlación entre dichas variables y la percepción subjetiva del esfuerzo (RPE) por género en alumnos de Educación Primaria. Un total de 69 alumnos de Educación Primaria participaron en el estudio (edad= 12,33±0,47 años, 55,9% niñas y 44,1% niños). La condición física y la composición corporal se evaluaron siguiendo los test de la ALPHA Fitness test Battery para niños y adolescentes. El rendimiento académico se estudió mediante el promedio de notas de las asignaturas instrumentales de Educación Primaria. La RPE se registró en las clases de EF y actividades físicas escolares mediante el uso de la escala RPE de Borg (0-10). Se establecieron correlaciones significativas entre la RPE y el peso de los chicos (r= 0,406, p= 0.02) y las chicas (r= 0,643, p< 0.001) y también con respecto al IMC, chicos (r= 0,508, p= 0.004), chicas (r= 0,621, p< 0.001). Existió una correlación negativa significativa entre el test de la Course Navette y la RPE en el caso de los niños (r= -0,633, p< 0.001) y de las niñas (r= -0,452, p= 0.004). La RPE se correlacionó significativamente con los palieres del test de Course Navette (correlación inversa) y las variables antropométricas, como son el peso y el IMC.
Miedo y depresión en la práctica del BMX en jóvenes deportistas de la liga Tunja-Boyacá, Colombia
Authors: Muñoz Gómez Liliana Paola , Flórez Flórez Jairo , Amaya Rojas Juan Sebastián
Published: December 2019

El presente estudio tuvo como objetivo explorar el miedo y la depresión en jóvenes deportistas de la liga de Tunja, en BMX, con una metodología de tipo descriptivo cuantitativo que da cuenta de resultados de investigación, los cuales se enmarcan dentro del campo de estudio de la educación física. Se suministró una escala a la totalidad de los corredores adscritos a la liga BMX, encontrando un total de 17 jóvenes que conforman el equipo, los cuales se encuentran entre los 17 a 23 años de edad, se midió el estado del ánimo, pesimismo, sentimientos de fracaso, insatisfacción, sentimiento de culpa, sentimiento de castigo, odio a sí mismo, autoacusación, impulso suicida y pedidos de llanto mediante el inventario de Depresión de Beck (2006), La escala se compone por 21 ítems con una validez, fiabilidad y equivalencia alta. Los resultados arrojaron que los deportistas no presentan niveles de depresión elevados, el estado de ánimo reporta dentro del promedio; aun así, los rangos más altos se ubican en sentimiento de fracaso y odio a sí mismo.
First report of Rutstroemia elatina (Ascomycota) from Turkey
Authors: AKATA İlgaz , ERDOĞDU Makbule
Published: December 2019

The purpose of this research was to identify Rustroemia samples from
Bolu province (Turkey) on June 22, 2019. The samples were identified
based on both conventional and molecular methods (ITS region of the
rDNA). By considering the high sequence similarity of the collected
samples (Akata 7020) with Rutstroemia elatina (Alb. & Schwein.)
Rehm, the relevant specimen was considered to be R. elatina and the
morphological data supported this finding. This species was firstly
reported from Turkey. The results of the molecular analysis and a
short description of the newly reported species along with its colored
images associated with macroscopic and microscopic structures were
conferred
Effects of 6-benzylaminopurine and Activated Carbon on Indirect Organogenesis of Fritillaria Imperialis
Authors: SAEED Nigar , CÖMERTPAY Sabahattin
Published: December 2019

Fritillaria imperialis needs 2-3 years to regenerate from seeds, which makes its production
quite challenging. In this study, effects of three concentrations of
6-Benzylaminopurine (BAP) (0.00, 0.10 and 0.15 mg/L) and three different
amounts (0.0, 3.0 and 3.5 g/L) of activated carbon (AC) on the growth of F.
imperialis plantlets in vitro were determined. The auxins were at
similar concentration (0.01 mg/L of NAA and 0.01 mg/L of IAA) for all
treatments. It has been found that the size and number of bulblets, as well as
root and shoot numbers in regenerated plantlets were increased significantly
(p<0.05) by adding 3.5 g/L of AC in culture medium supplemented with 0.10
mg/L of BAP. Moreover, addition of AC significantly reduced the length of roots
in all doses studied (p<0.05). The supreme concentration of BAP (0.15 mg/L)
decreased the bulblet number in all treatments, however, when supplemented with
3.5 g/L of AC, it was found to raise all the values measured (p<0.05).
Overall, the best growth of the plant parts from callus were achieved with the
highest concentration of AC and 1.5 mg/L of BAP.
GREEN SYNTHESIS OF SILVER NANOPARTICLES AS AN ANTIBACTERIAL AGENT: OPTIMIZATION OF SYNTHESIS CONDITIONS WITH RESPONSE SURFACE METHODOLOGY
Authors: ARSLANTÜRK Semra , UZUNOĞLU Deniz , ESER Esma , EKİZ Hacı İbrahim , ÖZER Ayla
Published: December 2019

In the present work, the synthesis of
silver nanoparticles (AgNPs) through a green synthesis method using avocado (Persea americana) leaf as a biological
reductant and capping agent. The synthesized AgNPs were characterized by
zetasizer, FTIR, UV-vis spectrophotometer, XRD, and SEM. Besides, response
surface methodology was used to understand and optimize the effect of the
experimental parameters on the green synthesis of AgNPs. Three experimental
parameters were chosen as independent variables: temperature, AgNO3 concentration,
and aqueous leaf extract volume. A quadratic model was established as a
functional relationship between three independent variables and the effective
hydrodynamic diameter (nm) of AgNPs. The results of model fitting and
statistical analysis demonstrated that only AgNO3 concentration was
statistically significant parameter. The optimum conditions for minimum
effective hydrodynamic diameter (nm) of AgNPs (32.74 nm) were temperature of 25
oC, AgNO3 concentration of 0.001 M, and aqueous leaf
extract volume of 50 mL. Moreover, the antibacterial activities of AgNPs for S. typhimurium, E. coli O157:H7, S. aureus,
and L. monocytogenes were tested and
it was found that AgNPs had stronger inhibitory
effects on growth of L. monocytogenes
than the other bacteria.
The influence of open innovation practices on business performance in Mexican family and non-family SMEs
Authors: García-Vidales Marisela-Yazmín , Maldonado-Guzmán Gonzalo
Published: December 2019

Open innovation has emerged as a topic of great importance due to the recognized benefits that it brings to the company's business performance; however, it has been sparsely addressed in SMEs from developing countries. Therefore, this study aims to analyze and discuss the relationship between open innovation and business performance in family and non-family SMEs in Mexico. A survey-based study was carried out on a sample of 308 firms. Following this, the data was analyzed through a structural equation model. The results show that for these companies, the outflow and especially the inflow of external knowledge exert a positive influence on business performance.
Service-learning in a Tourism, Hospitality, and Event Management Academic Program
Authors: Naaman Kevin , Hu Chengming , Howell Brandon , Wang Weixuan
Published: December 2019

One-hundred and twenty-three undergraduate students in three Tourism, Hospitality, and Event Management (THEM) courses participated in a survey that captured service-learning barriers and perceptions of the experiences over the course of the 2017 spring semester. Results from the exploratory factor analysis generated three distinct factors from the perceived benefits of service-learning: (1) civic engagement, (2) social awareness, and (3) translational learning. Statistically significant negative correlations were found between barriers and perceptions of service-learning benefits. Implications from this research includes the identification and creation of interventions to reduce barriers so students may receive the benefits associated with service-learning.
Festival Admission and Visitors’ Behavioral Intentions
Authors: Green Yvette , Chen Han , Williams Kim
Published: December 2019

Food festivals provide unique opportunities for leisure, social and cultural experiences, help generate business and income for the host community and promote a positive image of the local community. This study examines the behavioral intentions of first time and repeat visitors to revisit and recommend a festival when admission fee is charged vs no admission. The study also investigates the impact of admission fees on the intention to revisit and recommend the festival for different age groups. Two-way ANOVA and independent t-tests were used. Results found that admission fees impacted the intentions to revisit and recommend the festival.
Keywords: Festival, Behavioral intentions, Revisit, Recommendations, Admission fee, Age
Compensatory Health Beliefs Relate to Decision-Making Coherence and Health Patterns
Authors: Merillat Bethany D. , Gonz Claudia
Published: December 2019

This study tested hypotheses that link cognitive decision-making coherence and health behavioral patterns to the endorsement of compensatory health beliefs (CHBs). Structural equation modeling was used to investigate relationships among the latent variables Compensatory Health Beliefs and 2 other constructs: Decision-Making Coherence (measured by resistance to framing, under/overconfidence, applying decision rules, consistency in risk perception, and resistance to sunk cost bias), and Risk Tendencies with Health Consequences (measured by self-control, the Health Behavior Checklist, and risk perception scales). An online, adult, United States sample—recruited through Amazon.com®’s Mechanical Turk (MTurk)—was assessed. The model described key relationships for the MTurk sample. Low levels of Decision-Making Coherence and Risk Tendencies with Health Consequences were associated with increased endorsement of Compensatory Health Beliefs. Results can help clarify the relationship between health-related cognitions and actions, and impact the design of interventions that rely on the use of the CHB scale.
Anticoagulant activity of direct factor Xa inhibitors as a tool to ensure the effectiveness and safety of drugs intake
Authors: Vavilova T. V.
Published: December 2019

The thematic review presents modern solutions using oral anticoagulants with a focus on direct coagulation factor X inhibitors. It contains information about the pharmacodynamics and pharmacokinetics of apixaban and rivaroxaban against the background of different drug intake regimens - twice and once per day. There are shown studies of concentration dynamics and the corresponding functional response, measured using the integral method - the thrombin generation test, which is widely used in scientific research to describe hemostatic processes based on an objective quantitative assessment of the thrombin formation – a key coagulation cascade serine protease. The logical relationship between the pharmacodynamics of anticoagulant action and the clinical presentation of the effectiveness and safety of drugs is traced. The review provides links to actual literature and current clinical guidelines.
Relembrando Suzana Alice Cardoso
Authors: Mota Jacyra Andrade
Published: December 2019

Este texto traz para esta homenagem realizada pela ANPOLL, em seu XXIV Encontro Nacional, pequenos recortes da vida de Suzana Alice Cardoso, pesquisadora, professora, escritora, colega e amiga, que nos recordam a sua presença marcante nos vários caminhos que percorreu até 2 de maio de 2018, sempre com muita determinação, coragem, competência e sensibilidade.Os recortes se distribuem pela sua vida acadêmica, pela sua atividade como cidadã, pelas suas produções científicas e pelos relatos ficcionais, que se relacionam à sua vida pessoal.
Animal electricity, Ca2+ and muscle contraction. A brief history of muscle research.
Authors: Martonosi A N
Published: December 2019

This brief review attempts to summarize some of the major phases of muscle research from Leeuwenhoek's description of sarcomeres in 1674, through Galvani's observation of "animal electricity" in 1791, to the discovery of Ca2+ as the key messenger in the coupling of nerve excitation to muscle contraction. The emerging molecular mechanism of the contraction process is one of the great achievements of biology, reflecting the intimate links between physics, chemistry and the life Sciences in the solution of biological problems.
Particulate guanylyl cyclases: multiple mechanisms of activation.
Authors: Kobiałka M , Gorczyca W A
Published: December 2019

Cyclic GMP (cGMP), a key messenger in several signal transduction pathways, is synthesized from GTP by a family of enzymes termed guanylyl cyclases, which are found in two forms: cytosolic (soluble) and membrane-bound (particulate). The past decade has brought significant progress in understanding the molecular mechanisms that underlie the regulation of particulate guanylyl cyclases and new members of their family have been identified. It has become more evident that the basic mechanism of catalysis of guanylyl cyclases is analogous to that recognized in adenylyl cyclases. Here we review the known basic mechanisms that contribute to the regulation of particulate guanylyl cyclases.
Interaction of membrane skeletal proteins with membrane lipid domain.
Authors: Sikorski A F , Hanus-Lorenz B , Jezierski A , Dluzewski A R
Published: December 2019

The object of this paper is to review briefly the studies on the interaction of red blood cell membrane skeletal proteins and their non-erythroid analogues with lipids in model systems as well as in natural membranes. An important question to be addressed is the physiological significance and possible regulatory molecular mechanisms in which these interactions are engaged.
Participation of phospholipase A2 isoforms in the control of calcium influx into electrically non-excitable cells.
Authors: Zabłocki K , Waśniewska M , Duszyński J
Published: December 2019

The participation of phospholipase A2 isoforms in capacitative store-operated Ca2+ influx into Jurkat leukemic T and MDCK cells was investigated. Preincubation of Jurkat cells with either bromophenacyl bromide (an inhibitor of secreted phospholipase A2, sPLA2) or Helss (an inhibitor of calcium independent phospholipase A2--iPLA2) resulted in a significant inhibition of the calcium influx. The extent of this inhibition depended on the pH of the extracellular millieu; it increased with alkalisation. The rate of Ca2+ influx into MDCK cells was reduced by bromophenacyl bromide. Preincubation of these cells with Helss resulted in the stimulation of the influx. These observations suggest the participation of different PLA2 isoforms in the regulation of Ca2+ influx. They also show that the extent that PLA2 isoforms control the influx depends on the pH of the medium. Finally, these data indicate that various phospholipase A2 isoforms may play a role in the control of Ca2+ influx in different cell lines.
Molecular dynamics simulation studies of lipid bilayer systems.
Authors: Pasenkiewicz-Gierula M , Murzyn K , Róg T , Czaplewski C
Published: December 2019

The main structural element of biological membranes is a liquid-crystalline lipid bilayer. Other constituents, i.e. proteins, sterols and peptides, either intercalate into or loosely attach to the bilayer. We applied a molecular dynamics simulation method to study membrane systems at various levels of compositional complexity. The studies were started from simple lipid bilayers containing a single type phosphatidylcholine (PC) and water molecules (PC bilayers). As a next step, cholesterol (Chol) molecules were introduced to the PC bilayers (PC-Chol bilayers). These studies provided detailed information about the structure and dynamics of the membrane/water interface and the hydrocarbon chain region in bilayers built of various types of PCs and Chol. This enabled studies of membrane systems of higher complexity. They included the investigation of an integral membrane protein in its natural environment of a PC bilayer, and the antibacterial activity of magainin-2. The latter study required the construction of a model bacterial membrane which consisted of two types of phospholipids and counter ions. Whenever published experimental data were available, the results of the simulations were compared with them.
Influence of amphiphilic compounds on membranes.
Authors: Przestalski S , Sarapuk J , Kleszczyńska H , Gabrielska J , Hladyszowski J , Trela Z , Kuczera J
Published: December 2019

On the basis of Gortel & Grendel (J. Exp. Med., 1925, 41, 439-494) discovery, the importance of the lipid bilayer as an integral and indispensible component of the cell membrane is discussed. In particular, attention focuses on the interaction between membranes and amphiphilic substances. The effect on membranes of quaternary ammonium salts, both in the form of pesticides and oxidants as well as organic compounds of tin and lead are discussed in greater detail.
Liposomal drug delivery, a novel approach: PLARosomes.
Authors: Kozubek A , Gubernator J , Przeworska E , Stasiuk M
Published: December 2019

Almost from the time of their rediscovery in the 60's and the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications in humans and animals. Several commercial liposome-based drugs have already been discovered, registered and introduced with great success on the pharmaceutical market. However, further studies, focusing on the elaboration of more efficient and stable amphiphile-based vesicular (or non-viral) drug carriers are still under investigation. In this review we present the achievements of our group in this field. We have discovered that natural amphiphilic dihydroxyphenols and their semisynthetic derivatives are promising additives to liposomal lipid compositions. The presence of these compounds in lipid composition enhances liposomal drug encapsulation, reduces the amount of the lipid carrier necessary for efficient entrapment of anthracycline drugs by a factor of two, stabilizes liposomal formulation of the drug (both in suspension and in a lyophilized powder), does not influence liposomal fate in the blood circulation system and benefits from other biological activities of their resorcinolic lipid modifiers.
Effect of divalent metal ions on annexin-mediated aggregation of asolectin liposomes.
Authors: Mel'gunov V I , Akimova E I , Krasavchenko K S
Published: December 2019

Annexins belong to a family of Ca2+- and phospholipid-binding proteins that can mediate the aggregation of granules and vesicles in the presence of Ca2+. We have studied the effects of different divalent metal ions on annexin-mediated aggregation of liposomes using annexins isolated from rabbit liver and large unilamellar vesicles prepared from soybean asolectin II-S. In the course of these studies, we have found that annexin-mediated aggregation of liposomes can be driven by various earth and transition metal ions other than Ca2+. The ability of metal ions to induce annexin-mediated aggregation decreases in the order: Cd2+ > Ba2+, Sr2+ > Ca2+ > Mn2+ > Ni2+ > Co2+. Annexin-mediated aggregation of vesicles is more selective to metal ions than the binding of annexins to membranes. We speculate that not every type of divalent metal ion can induce conformational change sufficient to promote the interaction of annexins either with two opposing membranes or with opposing protein molecules. Relative concentration ratios of metal ions in the intimate environment may be crucial for the functioning of annexins within specialized tissues and after treatment with toxic metal ions.
Cellular aspects of folate and antifolate membrane transport.
Authors: Brzezińska A , Wińska P , Balińska M
Published: December 2019

Folates--one carbon carriers--take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.
Transport of glutathione-conjugates in human erythrocytes.
Authors: Sharma R , Awasthi S , Zimniak P , Awasthi Y C
Published: December 2019

The last step of detoxification of both endogenous and environmental toxicants is typically a conjugation that produces a bulky hydrophilic molecule. The excretion of such conjugates out of cells is of sufficient biological importance to have led to the evolution of ATP-driven export pumps for this purpose. The substrate specificity of such transporters is broad, and in some cases it has been shown to include not only anionic conjugates but also neutral or weakly cationic drugs. In the present article, we review the molecular identity, functional and structural characteristics of these pumps, mainly on the example of human erythrocytes, and discuss their physiological role in detoxification and in the multidrug resistance phenotype of cancer cells.
Determination of adenine nucleotides and their metabolites in human saliva.
Authors: Kochańska B , Smoleński R T , Knap N
Published: December 2019

The profile and normal concentrations of nucleotide metabolites in human saliva and reproducibility of these determinations were analyzed. Samples of human saliva collected from healthy individuals at weekly intervals, were deproteinized and analysed for the content of adenine nucleotides and their metabolites by reversed-phase HPLC. Initial ATP, hypoxanthine and uric acid concentrations were 0.52 +/- 0.15 microM, 1.91 +/- 0.37 microM and 184 +/- 22 microM respectively. A substantial individual variation persisted within 3 weeks of sampling excepted hypoxanthine which showed some unrelated variations. Determination of nucleotides and their catabolites in saliva due to its simplicity and reproducibility, may be of clinical value in diagnosis of local or systemic disorders.
Antioxidant defense in centenarians (a preliminary study).
Authors: Kłapcińska B , Derejczyk J , Wieczorowska-Tobis K , Sobczak A , Sadowska-Krepa E , Danch A
Published: December 2019

The study was designed to assess the antioxidant defense mechanisms, either enzymatic or non-enzymatic, in a group of sixteen centenarians (one male and fifteen female subjects aged 101 to 105 years) living in the Upper Silesia district (Poland) in order to evaluate the potential role of antioxidant defenses in human longevity. The results of our preliminary study showed that in comparison with young healthy female adults the centenarians had significantly higher red blood cell glutathione reductase and catalase activities and higher, although insignificantly, serum vitamin E level.
Effect of stress on the life span of the yeast Saccharomyces cerevisiae.
Authors: Swieciło A , Krawiec Z , Wawryn J , Bartosz G , Biliński T
Published: December 2019

A correlation is known to exist in yeast and other organisms between the cellular resistance to stress and the life span. The aim of this study was to examine whether stress treatment does affect the generative life span of yeast cells. Both heat shock (38 degrees C, 30 min) and osmotic stress (0.3 M NaCl, 1 h) applied cyclically were found to increase the mean and maximum life span of Saccharomyces cerevisiae. Both effects were more pronounced in superoxide dismutase-deficient yeast strains (up to 50% prolongation of mean life span and up to 30% prolongation of maximum life span) than in their wild-type counterparts. These data point to the importance of the antioxidant barrier in the stress-induced prolongation of yeast life span.
Direct transfer of IL-12 gene into growing Renca tumors.
Authors: Budryk M , Wilczyńska U , Szary J , Szala S
Published: December 2019

We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors causes a distinct therapeutic effect that depends on the time span between inoculation of mice with cancer cells and the beginning of the therapy. Therapy started on day 3 resulted in total cure (100%) of mice.
Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.
Authors: Asensio A C , Rodríguez-Ferrer C R , Oaknin S , Rotllán P
Published: December 2019

Human platelets diadenosine triphosphatase was characterised and compared with the Fhit protein, a human tumour suppressor with diadenosine triphosphatase activity. Both enzymes exhibit similar Km, are similarly activated by Mg2+, Ca2+ and Mn2+, and inhibited by Zn2+ and suramin. However, they are differentially inhibited by Fhit antibodies and exhibit differences in gel-filtration behaviour.
A Weighted Similarity Measure for k-Nearest Neighbors Algorithm
Authors: KARABULUT Bergen , ARSLAN Güvenç , ÜNVER Halil Murat
Published: December 2019

One of the most important problems in machine
learning, which has gained importance in recent years, is classification. The
k-nearest neighbors (kNN) algorithm is widely used in classification problem
because it is a simple and effective method. However, there are several factors
affecting the performance of kNN algorithm. One of them is determining an
appropriate proximity (distance or similarity) measure. Although the Euclidean
distance is often used as a proximity measure in the application of the kNN,
studies show that the use of different proximity measures can improve the performance
of the kNN. In this study, we propose the Weighted Similarity k-Nearest
Neighbors algorithm (WS-kNN) which use a weighted
similarity as proximity measure in the kNN algorithm. Firstly, it
calculates the weight of each attribute and similarity between the instances in
the dataset. And then, it weights similarities by attribute weights and creates
a weighted similarity matrix to use as proximity measure. The proposed
algorithm is compared with the classical kNN method based on the Euclidean
distance. To verify the performance of our algorithm, experiments are made on
10 different real-life datasets from the UCI (UC Irvine Machine Learning
Repository) by classification accuracy. Experimental results show that the
proposed WS-kNN algorithm can achieve comparative classification accuracy. For
some datasets, this new algorithm gives highly good results. In addition, we demonstrated
that the use of different proximity measures can affect the classification
accuracy of kNN algorithm.
Henry Steel Olcott’un Budizm Üzerine Çalışmaları ve Budist Kateşizm’i
Authors: Gül Ali
Published: December 2019

Henry Steel
Olcott modern spiritüalist (ruhçu) akımdan etkilenmekle beraber Teosofi
Cemiyeti ve Helena Petrovna Blavatsky ile birlikte yeni bir kariyere yelken
açmıştır. Cemiyetin kurucularından olan Olcott hayatı boyunca resmi başkanlık
görevini yürütmüştür. Teosofi Cemiyeti modern okültist hareketler içinde önemli
bir yere sahiptir. Amerika’da kurulan cemiyet bir süre sonra Hindistan’a
taşınmıştır; bu andan itibaren cemiyetin öğretilerinde Hint inanç ve
düşünceleri ağırlık kazanmıştır. Cemiyet Hindistan topraklarında sosyal,
kültürel ve siyasi çalışmalar yürütmüştür. Hint inanç ve düşüncelerinin Batı’ya
aktarılmasında cemiyet önemli bir araç olmuştur. Blavatsky’nin Hindistan’ı terk
etmesinden sonra Teosofi Cemiyeti’nin Hindistan’daki faaliyetlerinde Olcott’un
ismi tam anlamıyla öne çıkmıştır. Olcott’un özellikle Budizm’e yönelik
faaliyetleri dikkat çekicidir. Olcott, Seylan başta olmak üzere Burma ve
Japonya’da Budistlere yönelik çalışmalar yapmıştır. Onun hususen Seylan'da
Budizm’in canlanmasında büyük etkisi olmuştur. Kaleme aldığı Budist Kateşizm’in
(Budist İlmihal) ise çalışmaları arasında önemli bir yeri vardır. Olcott bu
eserinde geleneksel Budist öğretiler ile teosofik öğretileri bağdaştırma
gayreti gütmüştür. Bu makale bir yandan Olcott’un Budizm üzerine çalışmalarını
ve Budist Kateşizm’ini değerlendirmeyi diğer yandan Budist çalışmalar hakkında
Türkçe literatüre katkı sunmayı amaç edinmektedir.
Osmanlı Döneminde Yetişen “Kırımî” Nisbeli Müfessirler ve Eserleri: Bir Literatür İncelemesi
Authors: Gür Süleyman
Published: December 2019

Osmanlı döneminde tefsir ilmine dair
çok sayıda eser yazılmış olup bunların önemli bir bölümü kütüphanelerde yazma
halindedir. Ancak son zamanlarda yapılan çalışmalar sayesinde bu eserlerin bir
kısmı araştırmacıların hizmetine sunulmuştur. Bir kısmı ise hâlâ kütüphanelerde
ya da şahıs kitaplıklarında gün yüzüne çıkartılmayı beklemektedir. Bu tefsir
mirasının bir halkası da Kırım Türklerine aittir. Fatih Sultan Mehmed döneminde
Osmanlı hakimiyetine giren Kırım’da, tarih boyunca çok sayıda medrese kurulmuş,
bu medreselerde öğrenim gören talebeler, başta İstanbul olmak üzere, Osmanlı
coğrafyasının önemli merkezlerine yüksek tahsil için gitmişler ve gerek
gittikleri yerlerde gerekse kendi memleketlerinde eser telifi ile de
uğraşmışlardır. Onların çeşitli ilim dallarında telif ettikleri eserlerle
ilgili günümüzde şahıs ve eser merkezli bazı çalışmalar yapılmıştır. Ancak
tefsir ilmine dair müstakil bir çalışma bugüne kadar yapılmamıştır. Bu
çalışmada tefsir alanında eser veren Kırımlı müellifler ve onların ekseriyeti
kütüphanelerde yazma halinde olan eserlerini tespit edip tanıtmak ve böylece
ilim camiasına bir katkıda bulunmak hedeflenmiştir. Bu maksatla önce kütüphane
katalogları ve kaynaklar taranarak Kırım ulemasının tefsire dair eserleri
tespit edilmiş ardında bu eserler ve müellifleri kısaca tanıtılmıştır.
Ziyaüddin Sardar’ın Postnormal Zamanlar Teorisi Çerçevesinde Toplumsal Değişim Sürecinde Din Eğitimi Üzerine Bir Değerlendirme
Authors: Bilecik Sümeyra
Published: December 2019

Toplumsal değişim, hızı, etkisi ve kapsadığı alan değişmekle
birlikte her dönemde gerçekleşmiş bir olgudur. Toplumsal değişim sürecinden
etkilenen pek çok faktör arasında din ve eğitim de vardır. Dolayısıyla din
eğitiminde de toplumsal değişimle birlikte farklılaşmalar görülmektedir. Postnormal zamanlar; belirsizlik,
hızlı değişim, gücün yeniden düzenlenmesi, karışık ve kaotik davranışlarla
karakterize edilir. Ziyaüddin Sardar, postnormal zamanların özelliklerini üç
‘K’ ile açıklamaktadır. Bunlar, karmaşa, kaos ve karşıtlıktır. Sardar’a göre
ilişkide bulunduğumuz her şey karmaşık/komplikedir. Postnormal zamanların
ikinci özelliği kaostur. Kaosun asıl sebebi ise iletişim ağının doğasının,
kapsamının ve işlevinin değişmesidir. Sardar, karşıtlığı hızlı değişim ve
bilgiye ulaşma, bilgiyi kullanma ve yorumlamada meydana gelen değişimle
ilişkilendirerek bu üç husus çerçevesinde yaşadığımız çağın özelliklerinden
bahsetmektedir. Bu makalede Ziyaüddin Sardar’ın toplumsal değişimin
geldiği noktayı betimlerken kullandığı postnormal zamanlar teorisi çerçevesinde
Türkiye’de örgün ve yaygın din eğitimi incelenerek bu teorinin ortaya koyduğu
dönemsel özelliklere göre yorumlamak amaçlanmıştır. Teorik olan bu çalışmanın,
toplumsal değişim sürecinde ortaya çıkan ihtiyaçlar karşısında, örgün ve yaygın
din eğitiminin mahiyetini değerlendirmesi bakımından alana katkı sağlayacağı
düşünülmektedir.