bluuebunny/crossref_metadata_2025 huggingface dataset:
Vertical Dimension Control in Two Different Treatment Protocols: Invisalign First and Bite Block—A Retrospective Study
Authors: Laganà Giuseppina , Malara Arianna , Palmacci Daniel , Bollero Patrizio , Cozza Paola
Published: October 2024

Background: The aim of the present study was to compare the vertical dimension changes, before and after treatment, in two groups of growing patients, one group treated with clear aligner therapy versus a group treated with Quad-helix and bite-block therapy. Methods: The studied sample was composed of n. 40 patients (20 females and 20 males with a mean age of 8.6 ± 1.8 years), enrolled from the Department of Orthodontics at Policlinico of Rome Tor Vergata. The original sample was randomly divided into two groups: Group IF (Invisalign First) and Group BB (Quad-helix and bite block). Pre- (T0) and post-treatment (T1 after 12 months) lateral cephalograms were collected from all the selected patients. Nine cephalometric parameters, both angular and linear, were measured and recorded for each cephalogram. Results: No statistically significant changes were found between both the IF and BB groups at T0, while statistically significant changes were observed in both groups (BB and IF) between T0 and T1 (after 12 months of active therapy), p < 0.005. Conclusions: Both therapies were able to control the patient’s vertical condition. To date, the use of conventional appliances seems to have slightly better efficacy in controlling the vertical dimension than aligner therapy.
Genome-Wide Identification and Expression Analysis of the HSF Gene Family in Ammopiptanthus mongolicus
Authors: Zhao Shuai , Qing Jun , Yang Zhiguo , Tian Tian , Yan Yanqiu , Li Hui , Bai Yu’e
Published: October 2024

Ammopiptanthus mongolicus is an ancient remnant species from the Mediterranean displaying characteristics such as high-temperature tolerance, drought resistance, cold resistance, and adaptability to impoverished soil. In the case of high-temperature tolerance, heat shock transcription factors (HSFs) are integral transcriptional regulatory proteins exerting a critical role in cellular processes. Despite extensive research on the HSF family across various species, there has been no analysis specifically focused on A. mongolicus. In this study, we identified 24 members of the AmHSF gene family based on the genome database of A. mongolicus, which were unevenly distributed over 9 chromosomes. Phylogenetic analysis showed that these 24 members can be categorized into 5 primary classes consisting of a total of 13 subgroups. Analysis of the physical and chemical properties revealed significant diversity among these proteins. With the exception of the AmHSFB3 protein, which is localized in the cytoplasm, all other AmHSF proteins were found to be situated in the nucleus. Comparison of amino acid sequences revealed that all AmHSF proteins contain a conserved DNA-binding domains structure, and the DNA-binding domains and oligomerization domains of the AmHSF gene exhibit conservation with counterparts across diverse species; we investigated the collinearity of AmHSF genes in relation to those of three other representative species. Through GO enrichment analysis, evidence emerged that AmHSF genes are involved in heat stress responses and may be involved in multiple transcriptional regulatory pathways that coordinate plant growth and stress responses. Finally, through a comprehensive analysis using transcriptome data, we examined the expression levels of 24 AmHSFs under 45 °C. The results revealed significant differences in the expression profiles of AmHSFs at different time intervals during exposure to high temperatures, highlighting their crucial role in responding to heat stress. In summary, these results provide a better understanding of the role and regulatory mechanisms of HSF in the heat stress response of A. mongolicus, meanwhile also establishing a foundation for further exploration of the biological functions of AmHSF in the adversity response of A. mongolicus.
Knowledge and Awareness of Cancer Genome Profiling Tests among Japanese Patients with Cancer
Authors: Kawasaki Yuko , Sudo Tamotsu , Tamura Kazuo , Hinoshita Saki , Hasuoka Kayoko , Miyawaki Satoko , Matsutani Nao , Hirasawa Akira , Uchinuno Atsuko
Published: October 2024

(1) Background: The number of patients with cancer undergoing cancer genome profiling is increasing; however, it remains unclear how accurately they understand the details of the tests and treatments. This study aimed to clarify the awareness of cancer genome profiling tests among patients with cancer who visited cancer genome medical clinics. (2) Methods: A questionnaire survey was conducted on awareness, anxiety, sources of information, and psychological states concerning cancer genome profiling tests. (3) Results: In total, 265 patients with cancer (117 men, 142 women, 6 no response, average age of 58.29 ± 11.9 years) were included in the study, of which 218 (82.3%) were aware of the term “cancer genomic medicine” and 90 (34.0%) were aware of its details. Thus, only a few respondents understood that cancer genome profiling tests facilitate the discovery of secondary findings and of genes associated with hereditary tumors. Regarding their psychological state when visiting the cancer genome clinic, the respondents were anxious about standard treatment and prognosis limits. (4) Conclusions: From the viewpoint of advance care planning, we suggest that medical professionals build a support system that links palliative care and cancer treatment and coordinates genetic counseling at an early stage.
Placebos in Healthcare: A Behavioral Study on How Treatment Responsiveness Affects Therapy Decisions in a Simulated Patient–Physician Interaction
Authors: Piedimonte Alessandro , Volpino Valeria , Campaci Francesco , Borghesi Francesca , Guerra Giulia , Carlino Elisa
Published: October 2024

Background and Purpose: Treatment choice during clinical practice is crucial to best help each patient. One of the physicians’ main goals is choosing a personalized effective treatment, but it also represents a challenging issue. Here, we explored different treatment choices in a simulated patient–physician interaction. Materials and Methods: Medical students (n = 48) and young Practicing Physicians (n = 20) were recruited to behave as “physicians” while fellow researchers acted as “patients”. Participants were divided equally into a Belief Group, which received positive information about placebo efficacy, and a Non-Belief Group, which received negative information. Empathy traits and psychological variables were measured in both groups. During the task, participants were asked to choose between an active (TENS treatment) or a placebo treatment, to reduce patients’ pain. Patients never underwent the painful stimulation but acted as if they had, simulating high or low pain responses to the placebo treatment (placebo-responders/placebo non-responders) and low pain to the TENS treatment. Results: Behavioral results showed that the Belief Group gave significantly more placebo treatments when faced with a patient that simulated placebo responsiveness, while the Non-Belief group showed a mirrorlike behavior, administrating more believed TENS treatments when faced with a placebo non-responder. No differences were found between Medical Students and Practicing Physicians. Conclusions: This study constitutes a frame of reference for medical treatment decisions, indicating that physicians’ treatment choices are influenced by patients’ responsiveness to the treatments, as well as by their prior beliefs and empathy traits.
Association of Insomnia with Functional Outcomes Relevant to Daily Behaviors and Sleep-Related Quality of Life among First Nations People in Two Communities in Saskatchewan, Canada
Authors: Karunanayake Chandima P. , Dosman James A. , Ayas Najib , Fenton Mark , Seeseequasis Jeremy , Lindain Reynaldo , Seesequasis Warren , McMullin Kathleen , Kachroo Meera J. , Ramsden Vivian R. , King Malcolm , Abonyi Sylvia , Kirychuk Shelley , Koehncke Niels , Skomro Robert , Pahwa Punam
Published: October 2024

Insomnia is a common sleep complaint in Canada and is associated with increased use of health care services and economic burden. This paper examines the association of insomnia with functional outcomes relevant to daily behaviors and sleep-related quality of life among First Nations participants using the Functional Outcomes of Sleep Questionnaire (FOSQ-10). The First Nations Sleep Health Project follow-up survey was conducted in partnership with two Cree First Nations in the summer of 2022, where 355 individuals participated. Statistical analysis was conducted using logistic regression models. The mean age of the participants was 40.76 ± 14.60 (SD) years, and 59.4% were females. The prevalence of chronic insomnia (Insomnia Severity Index score of ≥15) was 21.0%, with more females (26.1%) than males (13.8%) experiencing it among the 348 participants. Overall, the mean FOSQ-10 score was 17.27 ± 2.98 among the 350 participants, with those who had clinical insomnia reporting significantly lower scores than those without clinical insomnia (mean ± SD: 14.6 ± 3.9 vs. 18.0 ± 2.1; p < 0.001). The FOSQ-10 scores indicated sleep-related functional impairment (FOSQ-10 total score < 17.90) in 46.6% of participants. After adjusting for age, excessive daytime sleepiness, sex, and regular use of prescription medication, we found that clinical insomnia was significantly associated with functional impairments. In fact, a person with clinical insomnia was 3.5 times more likely to have functional impairments than those without clinical insomnia. This study highlights the significant association between insomnia and functional impairments related to daily behaviors and quality of life in two First Nation communities. Identifying this association can help healthcare providers to diagnose and treat patients with insomnia in these communities.
Study on the Synergistic Effect of Several Sulfur Compounds to the Corrosion Attack of Copper in Liquefied Petroleum Gas
Authors: Wang Chaoben , Lu Yuan , Ma Jinghui , Wang Hu
Published: October 2024

During the process of liquefied petroleum gas (LPG) exploitation, various sulfide-containing gases are produced, which significantly bring about corrosion attacks to copper equipment and facilities. Investigations on the effects of sulfides, hydrogen sulfide (H2S), carbonyl sulfide (COS), and ethanethiol (C2H6S) on copper corrosion and synergistic mechanisms are of great significance for LPG production. This paper studied the synergistic corrosion effects of mixed sulfide-containing gases in LPG on copper plates, including the influence of H2S + COS, H2S + C2H6S, as well as H2S + COS + C2H6S. The results showed that there exists an apparent synergistic effect between different sulfide-containing gases, which decreased the critical point of corrosion and enhanced the severity of copper corrosion. SEM observation on corrosion products with the addition of different sulfide-containing gases demonstrated that the microstructures of corrosion products are significantly different, which reveals different corrosion mechanisms. By characterizing the corrosion products on copper surfaces, corresponding corrosion mechanisms were proposed. Individual H2S reacts with copper directly as chemical corrosion. The presence of water leads to the dissolution of H2S into water film at the copper surface and results in electrochemical corrosion in nature. COS tends to decompose into acidic gas H2S and CO2, which accelerates the electrochemical corrosion at the copper surface. C2H6S can react with copper directly as chemical corrosion. A mixture of different sulfur-containing gases enhanced the corrosion attack by synergistic effect.
Sodium Alginate–Montmorillonite Composite Film Coatings for Strawberry Preservation
Authors: Yan Xiaoping , Yu Zuolong , Chen Yao , Han Chao , Wei Yunxiao , Yang Fan , Qian Yan , Wang Yong
Published: October 2024

In this study, we prepared sodium alginate (SA) and montmorillonite (MMT) composite films for application in coatings for strawberry preservation. SA and MMT were used as the matrix and glycerol was used as a plasticizer. Six types of composite films with different MMT contents were compared by analyzing their mechanical properties, permeability, and preservation effects. The results show that the mechanical properties of the 10 and 20% MMT composite films were superior, with tensile strength and fracture elongation values reaching 63.09 and 48.06 MPa and 5.75 and 6.47%, respectively. Increased MMT content caused the water vapor permeability to decrease, while the effect on oil permeability was the opposite. A comparison of the preservation effect provided by the coatings showed that, on day 12, the weight loss, malondialdehyde content, and respiratory intensity of strawberries treated with the 20% MMT coating liquid decreased by 43.3, 25.8, and 57.1%, respectively, compared with the control. The contents of titratable acid, soluble sugar, total phenols, and soluble solids decreased by 25.8, 37.7, 25.9, and 14.5%, respectively. The results provide data support for the application of these new composite films as edible coatings for fruit preservation.
Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine
Authors: Bera Partha Sarathi , Mirza Yafia Kousin , Sachdeva Tarunika , Bera Milan
Published: October 2024

The smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added molecular entities. Therefore, regioselective ring-opening reactions of aziridines with various heteroatomic nucleophiles and carbon nucleophiles establish a useful synthetic methodology to synthesize biologically relevant β-functionalized alkylamines. The regio-selective ring-opening of aziridines is highly dependent on the substrate combination, and stereochemical control is challenging for Lewis acid-promoted reactions. Therefore, the development of a robust, catalytic ring-opening process that assists in the accurate prediction of regioselectivity and stereochemistry is highly desirable. Consequently, a large number of publications detailing distinct methods for aziridine ring-opening reactions can be found in the literature. In this review, we discuss several transition metal catalyzed cross-coupling reaction protocols for the ring opening of substituted aziridines with various carbon nucleophiles.
Crack Detection, Classification, and Segmentation on Road Pavement Material Using Multi-Scale Feature Aggregation and Transformer-Based Attention Mechanisms
Authors: Ashraf Arselan , Sophian Ali , Bawono Ali Aryo
Published: October 2024

This paper introduces a novel approach to pavement material crack detection, classification, and segmentation using advanced deep learning techniques, including multi-scale feature aggregation and transformer-based attention mechanisms. The proposed methodology significantly enhances the model’s ability to handle varying crack sizes, shapes, and complex pavement textures. Trained on a dataset of 10,000 images, the model achieved substantial performance improvements across all tasks after integrating transformer-based attention. Detection precision increased from 88.7% to 94.3%, and IoU improved from 78.8% to 93.2%. In classification, precision rose from 88.3% to 94.8%, and recall improved from 86.8% to 94.2%. For segmentation, the Dice Coefficient increased from 80.3% to 94.7%, and IoU for segmentation advanced from 74.2% to 92.3%. These results underscore the model’s robustness and accuracy in identifying pavement cracks in challenging real-world scenarios. This framework not only advances automated pavement maintenance but also provides a foundation for future research focused on optimizing real-time processing and extending the model’s applicability to more diverse pavement conditions.
Tracking the Trajectory and Predictors of Peritraumatic Distress among Chinese Migrants in Canada across the Three Years of the COVID-19 Pandemic
Authors: Yu Linke , Yang Lixia
Published: October 2024

Negative effects of the COVID-19 pandemic on mental health have been widely reported. Chinese populations, especially those living overseas, are highly vulnerable to mental health problems considering the unique challenges they faced during the pandemic. Even though the pandemic lasted for three years, little is known about the mental health condition of this special population over this time course. The current study aimed to assess peritraumatic distress among Chinese migrants in Canada and identify its consistent risk predictors across the three years of the pandemic (2020, 2021, 2022). Three groups of Chinese adult migrants (i.e., aged 18 or above) living in Canada were randomly recruited through social media and the internet to complete an online survey in 2020, 2021, and 2022 respectively. Peritraumatic distress was assessed with the COVID-19 Peritraumatic Distress Index (CPDI). Univariate analysis of variance (ANOVA) models and a subsequent hierarchical multiple regression model were conducted to track peritraumatic distress differences across the three years and identify potential risk factors. The results showed that the CPDI score increased from 2020 to 2022 and peaked in 2021. Age, birthplace, health status, perceived discrimination, self-contraction and family contraction worry were identified as significant sociodemographic and COVID-19-related predictors for peritraumatic distress (absolute βs = 2.16–9.00; ps < 0.05). The results provide insight into the mental health condition of overseas Chinese migrants across the three years of the pandemic.
Modifications in Immune Response Patterns Induced by Kynurenine and One-Residue-Substituted T Cell Epitopes in SARS-CoV-2-Specific Human T Cells
Authors: Tokano Mieko , Takagi Rie , Matsushita Sho
Published: October 2024

Peptide p176-190, derived from the SARS-CoV-2 spike protein, is one of the major T cell epitopes that elicits the HLA-DR-restricted IL-8 response of human CD4+ T cells. Using PBMCs from a healthy individual primed with an S-protein-based SARS-CoV-2 vaccine, we established a CD4+ T cell line (TM45) and cloned T cells (TM45.2) specific for the peptide. We showed that (i) co-incubation with kynurenine leads to increased IL-8; (ii) T cells incubated in the absence of kynurenine recovered the original levels of cytokine production; and (iii) peptide p176-190 substituted at 176 Leucine for neutral hydrophilic serine completely abolished the cytokine responses of TM45.2 cells, thereby suggesting that 176 L is the first anchor residue for binding to HLA-DR. These observations collectively indicate that (i) enhanced IL-8 responses can be induced by kynurenine, which is produced under infectious conditions in COVID-19; (ii) the response is not a permanent change in the T cell phenotype; and (iii) IL-8 responses associated with harmful neutrophil extracellular traps can be abrogated by a single amino acid substitution of the viral antigens. These findings may shed light on a novel strategy for designing vaccines for viral infections that are accompanied by increased kynurenine production.
A Study on Tooth Wear Mechanisms During the Bandsawing of Cr12MoV with a Bimetal Bandsaw Blade
Authors: Jia Yuzhen , Wu Jigang , Chen Yuqiang , Chen Bing , Liu Guoyue , Ouyang Zhiyong
Published: October 2024

Bandsaw blades are typical band-shaped cutting tools that are characterized by their low stiffness and micro-level cutting depth, resulting in distinct wear mechanisms compared to rigid cutting tools. In this study, the wear curve and wear mechanisms of the bandsaw tooth during the bandsawing of Cr12MoV cold-working steel were investigated. The tool life was divided into two stages: a rapid wear stage (Stage I) and a homogeneous wear stage (Stage II). In Stage I, the wear was dominated by chipping, although multiple wear mechanisms were found due to their relatively low manufacturing accuracy compared to rigid cutting tools, which resulted in remarkable differences in the cutting depth of each tooth. In Stage II, abrasive and adhesive wear were the primary wear mechanisms instead of chipping, which was related to the microstructure of Cr12MoV. Furthermore, methods for increasing bandsaw performance were proposed, based on the tooth wear mechanisms.
Differences in Health Care Expenditures by Cancer Patients During Their Last Year of Life: A Registry-Based Study
Authors: Strang Peter , Petzold Max , Björkhem-Bergman Linda , Schultz Torbjörn
Published: October 2024

Background. During the last year of life, persons with cancer should probably have similar care needs and costs, but studies suggest otherwise. Methods. A study of direct medical costs (excluding costs for expensive prescription drugs) was performed based on registry data in Stockholm County, which covers 2.4 million inhabitants, for all deceased persons with cancer during 2015–2021. The data were mainly analyzed with the aid of multiple regression models, including Generalized Linear Models (GLMs). Results. In a population of 20,431 deceased persons with cancer, the costs increased month by month (p < 0.0001). Higher costs were mainly associated with lower age (p < 0.0001), higher risk of frailty, as measured by the Hospital Frailty Risk Scale (p < 0.0001), and having a hematological malignancy. In a separate model, where those 5% with the highest costs were identified, these variables were strengthened. Sex and socio-economic groups on an area level had little or no significance. Systemic cancer treatments during the last month of life and acute hospitals as place of death had only a moderate impact on costs in adjusted models. Conclusions. Higher costs are mainly related to lower age, higher frailty risk and having a hematological malignancy, and the effects are both statistically and clinically significant despite the fact that expensive drugs were not included. On the other hand, the costs were mainly comparable in regard to sex or socio-economic factors, indicating equal care.
Failure Modes in Orthopedic Oncologic Reconstructive Surgery: A Review of Imaging Findings and Failure Rates
Authors: Shah Anuj , Cardoso Fabiano N. , Souza Felipe , Montreuil Julien , Pretell-Mazzini Juan , Temple H. Thomas , Hornicek Francis , Crawford Brooke , Subhawong Ty K.
Published: October 2024

Limb salvage surgeries utilizing endoprostheses and allografts are performed for a variety of oncologic conditions. These reconstructions can fail and require revision for many reasons, which are outlined and classified into mechanical failures (soft tissue failures, aseptic loosening, structural failure), non-mechanical failures (infection, tumor progression), and pediatric failures (physeal arrest, growth dysplasia). Distinct radiologic and clinical findings define specific failure subtypes but are sparsely illustrated in the radiology literature. Specifically, an understanding of the organizational structure of the failure modes can direct radiologists’ search for post-reconstruction complications, enhance an appreciation of their prognostic significance, and facilitate research by standardizing the language and conceptual framework around outcomes. The purpose of this review is to highlight the key radiologic findings and imaging studies of each failure mode in orthopedic oncologic reconstructive surgery in the context of risk factors, failure rates, prognosis and survival statistics, and clinical decision-making regarding chemotherapy, radiation, and revision surgery.
Notch3 and Its Clinical Importance in Ovarian Cancer
Authors: Jit Bimal Prasad , Behera Alisha , Qazi Sahar , Mittal Khushi , Kundu Subhadip , Bansal Babul , Ray MD , Sharma Ashok
Published: October 2024

Background: Ovarian cancer (OC) is the most prevalent gynecological malignancy in women, often diagnosed at an advanced stage due to the absence of specific clinical biomarkers. Notch signaling, particularly Notch3, is frequently activated in OC and contributes to its oncogenic role. Despite its known association with poor clinical outcomes, the biomarker potential of Notch3 remains inadequately explored. Methods: We investigated the biomarker potential of Notch3 in OC using multiple databases, including ONCOMINE, GEPIA, Human Protein Atlas, UALCAN, Kaplan–Meier Plotter, and LinkedOmics. We analyzed Notch3 expression levels, survival correlations, and clinicopathological parameters. Results: Notch3 expression was significantly upregulated in OC, as well as other cancers. Correlation analysis demonstrated that high Notch3 mRNA levels were associated with poor overall survival (OS) (p < 0.05) and relapse-free survival (p < 0.05) in OC patients. Human Protein Atlas data showed elevated Notch3 protein levels in OC tissues compared to healthy controls. Clinicopathological analysis indicated significant associations between Notch3 expression and patient age (p < 0.5), TP53 mutation status (p < 0.5), and cancer stage (p < 0.1). Additionally, genes such as WIZ, TET1, and CHD4 were found to be co-expressed with Notch3 in OC. Notch3 expression also correlated with immune cell infiltration in OC. Conclusions: Our bioinformatics analysis highlights Notch3 as a potential biomarker for poor prognosis in OC. However, further in vitro and in vivo studies, along with validation using larger tissue samples, are necessary to confirm its biomarker utility.
Secondary Angle Closure Glaucoma in Weill–Marchesani Syndrome
Authors: Coviltir Valeria , Burcel Miruna Gabriela , Marinescu Maria Cristina , Urse Bianca Maria , Danielescu Ciprian
Published: October 2024

We report a case of a 16-year-old girl presenting to our clinic with decreased visual acuity and increased intraocular pressure in both eyes. The ophthalmological examination revealed best-corrected visual acuity (BCVA) of 0.3 in the right eye (R.E.) and 0.4 in the left eye (L.E.) and intraocular pressure (IOP) of 46 mmHg in the R.E. and 42 mmHg in the L.E., with a 360° closed angle on gonioscopy, pupillary block due to bulging, a hyper-spherical lens and high corneal thickness, without ectopia lentis or cataract. The eyes responded poorly to pharmacological mydriasis; therefore, the lens equator could not be visualised. The patient had a history of pulmonary stenosis, short stature and no significant cognitive deficits. These elements point to the diagnosis of Weill–Marchesani syndrome, and the ophthalmological management was surgical, including lens extraction and the installation of a capsular tension ring, an intraocular lens and a Shunt ExPress implantation. Evolution was favourable, with improved BCVA of 0.7 in the R.E. and 0.63 in the L.E. and IOP of 14 mmHg in the R.E. and 13 mmHg in the L.E., without topical or systemic treatment at the 6-month follow-up. Weill–Marchesani syndrome has a complex presentation, with ophthalmological, musculoskeletal, cardiac and psychiatric manifestations. Usually, this leads to a need for a multidisciplinary approach. The ophthalmologic symptoms are often the cause of presentation to a specialist, and glaucoma is the most threatening of the ocular pathologies, with possible evolution into irreversible blindness; therefore, prompt surgery and careful follow-up become key components of the treatment plan. As a take-home message, we encourage a high degree of suspicion of Weill–Marchesani syndrome in such cases.
Visceral Obesity and Its Association with Severe Coronary Artery Calcification in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease
Authors: Kang Min Kyu , Song Jeung Eun , Kweon Young Oh , Tak Won Young , Park Soo Young , Lee Yu Rim , Park Jung Gil
Published: October 2024

Background/Objectives: The role of body composition parameters in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) with presence and severity of coronary artery calcification (CAC) is still not fully elucidated. We aimed to evaluate the impact of computed tomography (CT)-based body composition parameters in patients with MASLD with CAC severity. Methods: In this multicenter study, 1870 individuals underwent cardiac CT for the detection of CAC as well as ultrasonography for the diagnosis of hepatic steatosis. The presence of CAC was defined by a CAC score threshold of >0, while severe CAC was defined by a threshold of >300. Using the abdominal cross-sectional CT images at the L3 vertebra level, we analyzed the skeletal muscle index, visceral to subcutaneous adipose tissue ratio, and muscle density using the Hounsfield unit. Results: Of 648 patients with MASLD, the proportions of presence of CAC and severe CAC were 45.2% and 9.9%, respectively. Visceral obesity was not associated with the presence of CAC after adjustment for age, sex, smoking, statin therapy, type 2 diabetes, and advanced fibrosis (adjusted odds ratio (aOR), 1.38; 95% confidence interval (CI), 0.86–2.23; p = 0.180). However, visceral obesity was independently associated with severe CAC after adjustment for several metabolic risk factors (aOR, 3.54; 95% CI, 1.25–14.90; p = 0.039), and adjustment for atherosclerotic cardiovascular disease risk scores (aOR, 3.74; 95% CI, 1.31–15.79; p = 0.032). Conclusions: Visceral obesity may serve as a novel prognostic CT-based radiological biomarker for patients with MASLD with severe CAC.
Image Quality and Lesion Detectability of Low-Concentration Iodine Contrast and Low Radiation Hepatic Multiphase CT Using a Deep-Learning-Based Contrast-Boosting Model in Chronic Liver Disease Patients
Authors: Lim Yewon , Kim Jin Sil , Lee Hyo Jeong , Lee Jeong Kyong , Lee Hye Ah , Park Chulwoo
Published: October 2024

Background: This study investigated the image quality and detectability of double low-dose hepatic multiphase CT (DLDCT, which targeted about 30% reductions of both the radiation and iodine concentration) using a vendor-agnostic deep-learning-based contrast-boosting model (DL-CB) compared to those of standard-dose CT (SDCT) using hybrid iterative reconstruction. Methods: The CT images of 73 patients with chronic liver disease who underwent DLDCT between June 2023 and October 2023 and had SDCT were analyzed. Qualitative analysis of the overall image quality, artificial sensation, and liver contour sharpness on the arterial and portal phase, along with the hepatic artery clarity was conducted by two radiologists using a 5-point scale. For quantitative analysis, the image noise, signal-to-noise ratio, and contrast-to-noise ratio were measured. The lesion conspicuity was analyzed using generalized estimating equation analysis. Lesion detection was evaluated using the jackknife free-response receiver operating characteristic figures-of-merit. Results: Compared with SDCT, a significantly lower effective dose (16.4 ± 7.2 mSv vs. 10.4 ± 6.0 mSv, 36.6% reduction) and iodine amount (350 mg iodine/mL vs. 270 mg iodine/mL, 22.9% reduction) were utilized in DLDCT. The mean overall arterial and portal phase image quality scores of DLDCT were significantly higher than SDCT (arterial phase, 4.77 ± 0.45 vs. 4.93 ± 0.24, AUCVGA 0.572 [95% CI, 0.507–0.638]; portal phase, 4.83 ± 0.38 vs. 4.92 ± 0.26, AUCVGA 0.535 [95% CI, 0.469–0.601]). Furthermore, DLDCT showed significantly superior quantitative results for the lesion contrast-to-noise ratio (7.55 ± 4.55 vs. 3.70 ± 2.64, p < 0.001) and lesion detectability (0.97 vs. 0.86, p = 0.003). Conclusions: In patients with chronic liver disease, DLDCT using DL-CB can provide acceptable image quality without impairing the detection and evaluation of hepatic focal lesions compared to SDCT.
Extensive Synovial Chondromatosis of the Temporomandibular Joint Extending to the Cranial Base
Authors: Sung Chi-Heon , An Seo-Young , Park Hae-Seo , Lee Wonae , Kim Moon-Young
Published: October 2024

A 42-year-old male presented to the Department of Oral and Maxillofacial Surgery with the chief complaint of pain and stiffness in the right temporomandibular joint (TMJ). The patient’s height was 174 cm and his body weight was 65 kg. The patient’s occupation was heavy equipment operator. According to the patient, the pain had initiated a week prior to his first visit and was exacerbated during mastication. Evaluation of the range of motion revealed extensive crepitus along the right TMJ. The active and passive range of motion were measured at 45 mm and 42 mm, respectively, indicating adequate mouth-opening capacity. Occlusion was also favorable, and no other clinical symptoms were shown intraorally.
Rapid Molecular Diagnostics in Vulvovaginal Candidosis
Authors: Akinosoglou Karolina , Schinas Georgios , Papageorgiou Despoina , Polyzou Eleni , Massie Zoe , Ozcelik Sabriye , Donders Francesca , Donders Gilbert
Published: October 2024

Background/Objectives: Vulvovaginal candidosis (VVC) is a common condition among women, with current diagnostic methods relying on clinical evaluation and laboratory testing. These traditional methods are often limited by the need for specialized training, variable performance, and lengthy diagnostic processes, leading to delayed treatment and inappropriate antifungal use. This review evaluates the efficacy of molecular diagnostic tools for VVC and provides guidance on their application in clinical practice. Methods: A literature search was conducted using PubMed to identify studies evaluating rapid diagnostic tests specifically for vulvovaginal Candida isolates. Inclusion criteria focused on studies utilizing molecular diagnostics for the detection of Candida species in VVC. Articles discussing non-vaginal Candida infections, non-English studies, and animal or in vitro research were excluded. Results: Twenty-three studies met the inclusion criteria, predominantly evaluating nucleid acid amplification tests/polymerase chain reaction (NAAT/PCR) assays and DNA probes. PCR/NAAT assays demonstrated high sensitivity and specificity (>86%) for VVC diagnosis, outperforming conventional diagnostic methods. Comparatively, DNA probes, while simpler, exhibited lower sensitivity. The included studies were mostly observational, with only one randomized controlled trial. Emerging diagnostic technologies, including artificial intelligence and integrated testing models, show promise for improving diagnostic precision and clinical outcomes. Conclusions: Molecular diagnostics offer a significant improvement in VVC management, though traditional methods remain valuable in resource-limited settings.
Spontaneous Headshake after a Kinematic Event (SHAAKE): Evaluating the Utility of a Potential New Sign in the Diagnosis of Concussion
Authors: Nowinski Christopher J. , Bureau Samantha C. , Rhim Hye Chang , Zafonte Ross D. , Cantu Robert C. , Daneshvar Daniel H.
Published: October 2024

Background/Objectives: Diagnosing concussions is problematic, in part due to the invisible nature of concussion symptoms, in addition to personal and interpersonal factors that influence symptom reporting. As a result, observable signs of concussion can ensure concussions are identified and appropriately treated. Here, we define a potential novel sign, the spontaneous headshake after a kinematic event (SHAAKE) and evaluate its utility in the diagnosis of concussion. Methods: A cross-sectional survey study of 347 athletes (age 27, IQR: 25–29; 47.6% female; highest level of play: college—46.1%, high school—41.2%) identified whether SHAAKE occurred, the reasons underlying SHAAKEs, and its utility for self-reported concussion. Sensitivity and positive predictive value were calculated across all sports and these parameters, as well as estimates for specificity and negative predictive value leveraging published helmet sensor data, were calculated for football players. Results: The median number of times participants reported SHAAKE was 5 (IQR: 3–10), with 4 (IQR: 2–7) associated with a self-reported concussion. Overall, 84.9% of participants reported concussion symptoms as the most common reason for their SHAAKEs. Across all sports, SHAAKE had a sensitivity of 49.6% and positive predictive value 72.4% for diagnosing concussion. In football players, SHAAKE had a sensitivity of 52.3%, estimated specificity of 99.9%, positive predictive value of 91.9%, and estimated negative predictive value of 99.5% for diagnosing self-reported concussion. Conclusions: These results demonstrate that nearly three-quarters of athletes reported a SHAAKE associated with a self-reported concussion, which supports the potential for SHAAKE to be used as a concussion screening tool.
Brokering Employment Pathways from Supported Employment Settings to the Mainstream Labour Market
Authors: Campbell Perri , Joyce Andrew , Wilson Erin , Eversole Robyn , Crosbie Jenny
Published: October 2024

In Australia, many people with a disability work in Supported Employment Settings (previously known as Australian Disability Enterprises or ADEs). SESs are in a unique position to provide training and support to people with a disability as a transition step to employment in the mainstream labour market. This paper examines how one case study SES facilitates pathways to open employment for supported employees. We explore three key questions: what do these pathways look like, what role can Supported Employment Settings play in facilitating these transitions, and what are the challenges in doing so? We argue that successful pathways involve SESs and employers working together to create bespoke opportunities tailored to individuals. Through a detailed picture of the actors and relationships that are involved in setting up employment pathways, our findings demonstrate the need for both employee and employer preparation and how this can be carried out through purposeful planning.
An Analysis of the Use of Topical Ocular Anti-Infectives in Galicia (Spain) between 2020 and 2023
Authors: Vázquez-Prieto Severo , Vaamonde Antonio , Paniagua Esperanza
Published: October 2024

Eye infections are a global health and economic problem that affect people of both sexes at any age. Topical application of anti-infectives is widely used in the treatment of these types of infections. However, little is known about the current status and trends of the use of topical ocular anti-infectives in Spain. In the present work, we evaluated the use of this type of drug in the Spanish autonomous community of Galicia and described the variability in its consumption between Galician provinces between 2020 and 2023. In addition, the possible existence of a deviation in consumption at a seasonal level was evaluated, as well as possible changes during the study period. A descriptive, cross-sectional and retrospective study of the use of drugs belonging to the subgroups S01A (anti-infectives) and S01C (anti-inflammatory agents and anti-infectives in combination) of the Anatomic Therapeutic Chemical Classification was carried out. This work demonstrated that the most used topical ocular anti-infective in Galicia was tobramycin and that the use of these types of drugs in our region varied according to the provinces. This study also revealed that the consumption of these medications has remained stable during the period 2020–2023, with no significant seasonal differences observed.
Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: Insights from the Western Australian Context
Authors: Oey Oliver , Lin Chak Pan , Khattak Muhammad Adnan , Ferguson Thomas , Theophilus Mary , Tiong Siaw Sze , Ali Sayed , Khan Yasir
Published: October 2024

Background: Recent studies have associated total neoadjuvant therapy (TNT) with better treatment adherence, decreased toxicity, improved complete clinical response and anal sphincter preservation rates in patients with locally advanced rectal cancer (LARC). However, real-world experience with TNT in the management of LARC remains limited. Aim: This study aimed to evaluate the efficacy and safety outcomes of TNT for LARC in Western Australia. Methods: Patients with LARC (cT2-4 and/or cN1-2) who underwent induction chemotherapy followed by neoadjuvant chemoradiotherapy or neoadjuvant chemoradiotherapy followed by consolidation chemotherapy, followed by surgery were recruited from two hospitals in Western Australia. Efficacy outcomes assessed included clinical response (complete, partial, no response), and pathologic complete response (pCR) rate, R0 resection rate, and R1 resection rate were evaluated. Those patients who achieved clinical complete response following TNT were given the option of active surveillance. The safety and tolerability of TNT were assessed. Results: 32 patients with LARC were treated with TNT. In total, 17 patients (53%) received chemoradiotherapy followed by consolidation chemotherapy and 15 patients (47%) received induction chemotherapy followed by chemoradiotherapy. Nine (28%) of the patients with LARC treated with TNT had a complete clinical response, twenty-one (66%) patients had a partial clinical response, and two (6%) patients had no response to TNT. Of the 32 patients, 27 (84%) underwent surgery. There was a 100% R0 resection rate. The pCR rate was 15%. pCR, clinical response, and the R0 resection rate were similar between the two TNT regimens. TNT was well tolerated, with the majority of patients (88%) completing the chemotherapy course with grade 1 and 2 adverse effects. Conclusions: In conclusion, TNT emerges as a promising approach for the management of LARC. However, further research is warranted to refine the optimal TNT protocols, determine its long-term outcomes, and identify patient populations who would benefit the most from this innovative therapeutic strategy.
Real-Time Trajectory Planning and Effectiveness Analysis of Intercepting Large-Scale Invading UAV Swarms Based on Motion Primitives
Authors: Zhang Yue , Gao Xianzhong , Zong Jian’an , Leng Zhihui , Hou Zhongxi
Published: October 2024

This paper introduces a swift method for intercepting the state trajectory of large-scale invading drone swarms using quadrotor drones. The research primarily concentrates on the design and computation of multi-target interception trajectories, with an analysis of the trajectory state constraints inherent to multi-target interception tasks. Utilizing Pontryagin’s principle of motion, we have designed computationally efficient motion primitives for multi-target interception scenarios. These motion primitives’ durations have informed the design of cost matrices for multi-target interception tasks. In contrast to static planar scenarios, the cost matrix in dynamic scenarios displays significant asymmetry, correlating with the speed and spatial distribution of the targets. We have proposed an algorithmic framework based on three genetic operators for solving multi-target interception trajectories, offering certain advantages in terms of solution accuracy and speed compared to other optimization algorithms. Simulation results from large-scale dynamic target interception scenarios indicate that for an interception task involving 50 targets, the average solution time for trajectories is a mere 3.7 s. Using the methods proposed in this paper, we conducted a comparative analysis of factors affecting the performance of interception trajectories in various target interception scenarios. This study represents the first instance in existing public research where precise evaluations have been made on the trajectories of drone interceptions against large-scale flying targets. This research lays the groundwork for further exploration into game-theoretic adversarial cluster interception methods.
Transported Entropy of Ions and Peltier Coefficients in 8YSZ and 10Sc1CeSZ Electrolytes for Solid Oxide Cells
Authors: Gedik Aydan , Kabelac Stephan
Published: October 2024

In this study, the transported entropy of ions for 8YSZ and 10Sc1CeSZ electrolytes was experimentally determined to enable precise modeling of heat transport in solid oxide cells (SOCs). The Peltier coefficient, crucial for thermal management, was directly calculated, highlighting reversible heat transport effects in the cell. While data for 8YSZ are available in the literature, providing a basis for comparison, the results for 10Sc1CeSZ show slightly smaller Seebeck coefficients but higher transported ion entropies. Specifically, at 700°C and an oxygen partial pressure of pO2=0.21 bar, values of SO2−*=52±10 J/K·F for 10Sc1CeSZ and SO2−*=48±9 J/K·F for 8YSZ were obtained. The transported entropy was also validated through theoretical calculations and showed minimal deviations when comparing different cell operation modes (O2||O2−||O2 and H2, H2O||O2−||O2). The influence of the transported entropy of the ions on the total heat generation and the partial heat generation at the electrodes is shown. The temperature has the greatest influence on heat generation, whereby the ion entropy also plays a role. Finally, the Peltier coefficients of 8YSZ for all homogeneous phases agree with the literature values.
An Evaluation on the Potential of Large Language Models for Use in Trauma Triage
Authors: Le Kelvin , Chen Jiahang , Mai Deon , Le Khang Duy Ricky
Published: October 2024

Large Language Models (LLMs) are becoming increasingly adopted in various industries worldwide. In particular, there is emerging research assessing the reliability of LLMs, such as ChatGPT, in performing triaging decisions in emergent settings. A unique aspect of emergency triaging is the process of trauma triaging. This process requires judicious consideration of mechanism of injury, severity of injury, patient stability, logistics of location and type of transport in order to ensure trauma patients have access to appropriate and timely trauma care. Current issues of overtriage and undertriage highlight the potential for the use of LLMs as a complementary tool to assist in more accurate triaging of the trauma patient. Despite this, there remains a gap in the literature surrounding the utility of LLMs in the trauma triaging process. This narrative review explores the current evidence for the potential for implementation of LLMs in trauma triaging. Overall, the literature highlights multifaceted applications of LLMs, especially in emergency trauma settings, albeit with clear limitations and ethical considerations, such as artificial hallucinations, biased outputs and data privacy issues. There remains room for more rigorous research into refining the consistency and capabilities of LLMs, ensuring their effective integration in real-world trauma triaging to improve patient outcomes and resource utilisation.
Universal Service Regulation and Network Effects in Services of General Economic Interest in the European Union
Authors: Pateiro-Rodríguez Carlos , Martín-Bermúdez Federico , Pateiro-López Carlos , Escourido-Calvo Manuel
Published: October 2024

The process of the liberalisation of services of general economic interest (SGEI) in the EU adopted the universal service (US) regulatory model. The objectives of the process were to strengthen free competition and improve social welfare. SGEIs have the characteristic of networked services and, as such, generate network externalities, as considered by the theory of market failures. This paper analyses the potential of the US in its role as a remedy for network externalities. In the SGEI context, the large number of participants reinforces network externalities, while limiting coordination mechanisms between users. Based on the relevant literature, a theoretical debate arises around the contribution of universal service obligations (USOs) to social welfare. A microeconomic analysis shows that USOs modify consumers’ utility functions by shifting from inefficient market equilibria to efficient equilibria, thereby improving social welfare.