bluuebunny/crossref_metadata_2025 huggingface dataset:
OTHR-08. MULTIDISCIPLINARY APPROACH TO PAEDIATRIC BRAIN CANCER BIO-BANKING IMPROVES ENROLLMENT, FACILITATES DISCOVERY RESEARCH, AND ENABLES BETTER ACCESS TO DIAGNOSTIC AND THERAPEUTIC STUDIES
Authors: Zhukova Nataliya , Habarakada Dilru , Drinkwater Caroline , Danks Andrew , Xenos Chris , Kumar Beena , Haddad Lauren , Daniel Paul , Sun Claire , Wood Paul , Super Leanne , Janson Lisa , Cain Jason , Firestein Ron , Downie Peter
Published: June 2023

Despite the significant progress made in the multi-modal treatment of childhood malignancies over the last four decades with a concomitantly increased cure rates, the benefit is still largely limited to patients with leukemias, lymphomas and localized non-CNS solid tumors, leaving patients with high-risk non-CNS solid tumours and most CNS malignancies with minimal advancements. More research is critical to understand what drives these cancers and to investigate the best ways to deliver curative therapies. Translational research relies on patient-derived tissue samples, animal models and cell-cultures to understand the biological, genetic, and molecular mechanisms of disease. To facilitate patient care and outcomes it is becoming increasingly important that paediatric clinical trials include tissue availability as part of eligibility criteria, making collection and storage of patient tissue a mandate of personalized medicine and a pillar of modern paediatric cancer medicine.

Monash Children’s Cancer Biobank was established in 2011. Since 2017, a total of 64 patients were diagnosed with CNS malignancies across all grades, with an overall 69% of patients’ tissues being bio-banked at the time of initial diagnosis. Through the combination of an educational forum, regular multi-disciplinary meetings, and the early involvement of medical oncology and biobank staff, with our neurosurgical and clinical pathology colleagues, as part of patient management planning, the tissue acquisition for bio-banking increased from 44% to 82% over the course of 5 years. This consequently led to a 100% enrollment to tissue-enabling studies allowing for banking of both fresh-frozen tissue and living cell-line models, facilitating discovery research efforts as part of the Victorian Paediatric Cancer Consortium’s molecular analysis pipeline (https://vicpcc.org.au/dashboard). This significantly improves opportunities for identification of targetable pathways, access to targeted therapies, enrollment onto treatment clinical trials and identification of patients with cancer predisposition syndromes.
OTHR-10. COLLABORATIVE EFFORTS FOR HOSPITAL-BASED BIOBANK DEVELOPMENT AND OPTIMIZATION TO ENSURE QUALITY PEDIATRIC SPECIMENS FOR TRANSLATIONAL RESEARCH
Authors: Lebert Brittany , Gonzalez-Vega Maxine , Elbabaa Samer , Hegert Julia , Wright Avery , Aguilar-Bonilla Ana , Smith Amy
Published: June 2023

In recent years, drastic improvements in sequencing technologies have led to a better understanding of the specific genetic drivers of cancer. However, one of the greatest barriers to these discoveries is access to primary patient tumor tissue, especially in cancers of the Central Nervous System (CNS). In many cases tissue from surgery is processed and stored in Formalin-Fixed Paraffin-Embedded (FFPE) blocks, which sets limitations on downstream applications. In 2015, our team launched an initiative to collect and efficiently store samples from pediatric CNS tumor patients during surgeries and autopsies. Through extensive collaboration between Neuro-Oncology, Neurosurgery, Pathology, and our Translational Laboratory, we have optimized the collection process to effectively preserve sample integrity and therefore maximize their potential usage. To date, we have collected over 4,509 samples from 293 patients (636 flash-frozen tissue, 1,026 plasma & buffy coat, 748 serum, 996 whole blood, 316 Cerebrospinal Fluid (CSF), and 787 parental blood samples). In addition, we have cultured 31 primary cell lines and collected over 242 dissociated tumor specimens for implantation into patient-derived xenograft (PDX) mouse models. Through our partnership with neurosurgery and pathology, we are permitted to attend surgeries and autopsies to immediately flash-freeze tumor tissue in liquid nitrogen, typically within minutes of the tissue being removed from the body. This immediate flash-freezing process aims to ensure specimen integrity and preserve molecular profiles. From there, the tissue is either stored in our -140oC freezer for future use or sent to partnered consortiums, including the Children’s Brain Tumor Network (CBTN) and Gift from a Child. Since the optimization of the collection process, the focus has now shifted to investigating the efficacy of our storage methods by quantifying DNA/RNA integrity over time. By ensuring the successful preservation of the samples, we can maximize their impact in the pediatric neuro-oncology research field.
OTHR-14. PROFILE & OUTCOME OF BRAIN TUMORS IN THE YOUNG CHILDREN < 3YEARS OF AGE: EXPERIENCE FROM A TERTIARY CANCER CENTER IN INDIA
Authors: Thankamony Priyakumari , Nair Manjusha , Rajeswary Binitha , CS Guruprasad , VR Prasanth
Published: June 2023

During the 5 year period from 1st January 2009- 31st December 2013, 33 children< 3 years age presented with brain tumor (7.56 % of all brain tumors among in children aged 0-14 years) . 54.5% were boys. Vomiting(69.7%) ataxia(36%) & head ache(24%) were the most common symptoms. Common histology included Medulloblastoma (36%) , Astrocytoma ( 21%) & Ependymoma ( 18%).Others included ATRT, glioma, ganglioglioma, PNET, Pineoblastoma & choroid plexus carcinoma. 63% were infratentorial & 37% were supratentorial. 58% had gross total resection & 36% had residual disease post surgery .64% of children received chemotherapy with baby brain protocol consisting of Inj VCR 0.06mg/kg IV - D1 &Inj Cyclophosphamide 50mg/kg IV infusion D1 (Cycle A) alternating with Inj CDDP 4m/kg as IV infusion D1&Inj Etoposide 6.5mg/kg IV infusion D1-3( Cycle B) as A – A – B Q3 weeks followed by definitive RT at completion of 3 years or earlier if they relapse on chemotherapy . At a median follow up of 34 months ( ( 2 mo- 106 mo ) 3 year RFS & OS were 20% & 56% respectively. OS was better for Ependymoma ( 100%) & Astrocytoma (80%) compared to (56% )for Medulloblastoma.
XRT-02. SINGLE-CELL RNA SEQUENCING IDENTIFIES FUNCTIONAL MACROPHAGE SUBSETS THAT ARE ENRICHED IN RESPONSE TO DIFFERENTIAL PHAGOCYTOSIS INDUCTION AGAINST GLIOMA
Authors: Lakshmanachetty Senthilnath , Riemondy Kent , Donson Andrew , Balakrishnan Illango , Venkataraman Sujatha , Vibhakar Rajeev , Foreman Nicholas , Mitra Siddhartha
Published: June 2023

Pediatric diffuse midline gliomas (DMGs), are fatal brain tumors of childhood arising in the ventral pons. Currently, radiation therapy (RT) is the mainstay treatment for DIPG. However, RT is not a curative treatment and provides only temporary relief for most patients. Recent advances in immunotherapy have yielded some fantastic opportunities to effectively treat patients with high-grade pediatric brain tumors. In this study, we demonstrate that fractionated RT (4Gy X 3) induces immunogenic cell death and activates multiple damage-associated molecular patterns (DAMPs) on DMG/DIPG cells. Furthermore, combining 4Gy X 3 with anti-CD47 therapy enhances the in vitro phagocytosis of DIPG/DMG cells by peripheral blood mononuclear cell-derived macrophages. Next, using single-cell RNA sequencing (scRNA-seq), we investigated the transcriptomic profile of macrophages that were co-cultured with irradiated or non-irradiated DMG cells in the presence of anti-CD47 monoclonal antibodies for 24 hours. Our findings identified eleven distinct macrophage clusters displaying different gene expression patterns in all the treatment conditions. However, PBS treatment led to a marked increase in macrophages expressing antigen-presentation genes (HLA-DR and HLA-DQB1). 4Gy X 3 treatment led to the enrichment of macrophages expressing genes related to the oxidative phosphorylation pathway, whereas anti-CD47 treatment led to the enrichment of macrophages expressing genes related to interferon-gamma response and ERK-signaling pathway. Lastly, mice intracranially transplanted with DMG/DIPG that received 4Gy X 3 and anti-CD47 therapy showed a significant decrease in tumor growth and an increase in survival rate than those receiving either monotherapy alone. We are currently performing scRNA-seq validation studies on tumors obtained from orthotopic and syngeneic models of DMG. In summary, our results highlight the functional heterogeneity of macrophages and suggest that combining fractionated RT with anti-CD47 therapy has distinct anti-tumor effects and can be used as a therapeutic approach for treating DIPG patients.
XRT-05. LITHIUM PREVENTS RADIATION-INDUCED HIPPOCAMPAL MICROGLIA SENESCENCE IN A MOUSE MODEL OF PEDIATRIC CRANIAL RADIOTHERAPY
Authors: Rodrigues Carlos , Preka Efthalia , Lastra-Romero Alejandro , Zisiadis Georgios Alkis , Zisiadis Christodoulos , Fragkopoulou Adamantia , Blomgren Klas
Published: June 2023

Radiotherapy is essential in the treatment of high-grade brain tumors. While often lifesaving, it typically results in long-term complications in 50-96 % of the treated individuals, where cognitive deficits are particularly debilitating, especially in pediatric patients. Although the survival rates have improved dramatically, there are currently no treatments or preventive strategies available to ameliorate the late cognitive complications. Lithium (Li), long used to treat patients with bipolar affective disorders, has been shown to reduce irradiation-induced cognitive deficits in rodent models by preventing apoptosis of the neuronal stem and progenitor cells in the hippocampus and stimulating their division. However, except for these anti-apoptotic and pro-neurogenic effects, there is limited understanding of how Li exerts its actions in the brain. This work aimed to further elucidate the mechanisms behind the protective action of Li in the irradiated young brain. To this end, post-natal day (PD) 21 C57BL6/J mice were intraperitoneally injected with lithium chloride (4 mmol/kg) and subsequently kept on a Li carbonate diet for 4 weeks. Control animals were injected with saline and administered an equivalent control diet. At PD25, the animals were subjected to a single dose of 8 Gy whole brain irradiation, and 6 weeks after irradiation, they were sacrificed, and their hippocampi were harvested for single-cell RNA sequencing and RT-qPCR. The attained results showed that irradiation induced hippocampal microglia senescence, as judged by the increased expression of the senescence-associated genes Cdkn1a, Cdkn2, Ccl12, C/Ebp and others in this cellular population. Conversely, Li prevented microglia senescence by activating the Bcl2 family of genes, as confirmed by the lower expression of the abovementioned senescence-associated genes in the Li-treated animals. These results provide the first step towards understanding the action of Li in the brain and confirm its potential to become the first pharmacological treatment for irradiation-induced late cognitive effects.
TRLS-04. PRECLINICAL VALIDATION OF A NOVEL THERAPEUTIC STRATEGY FOR CHOROID PLEXUS CARCINOMA
Authors: Martin Brice , Garman Tyler , Laramee Madeline , Wang Amy , Zhang Xiaohu , Beck Erin , Wilson Kelli , Klumpp-thomas Carleen , Mcknight Crystal , Xu Xin , Hagen Natalie , Holland David , Thomas Craig , Thomas Nadia , Souweidane Mark
Published: June 2023

Choroid plexus carcinoma is a very rare pediatric tumor located in the fourth and lateral ventricles of the brain. It is known to have a severe clinical history and significant side effects because of intensive and noxious chemotherapies. Due to the disease’s rarity and the scarcity of biologically relevant substrates, the advance of new therapeutical techniques for this condition has been exceedingly constrained. A human patient-derived CPC cell line (CCHE-45, Children Cancer Hospital Egypt) was subjected to a high-throughput screen (HTS); 427 top hits were identified, highlighting critical molecular targets in CPC. Additionally, a combination screen with numerous different targets identified synergistic combinations that lead the way for brand-new CPC therapies. Based on in vitro efficiency, CNS penetrance ability and feasible translational potential, two combinations using a DNA alkylating or topoisomerase inhibitors in combination with an ataxia telangiectasia mutated and rad3 (ATR) inhibitor (topotecan/elimusertib and melphalan/elimusertib respectively) were validated in vitro and in vivo. Pharmacokinetic studies revealed greater CNS penetrance via intra-arterial (IA) delivery compared to intravenous (IV) delivery, as well as increased CNS penetrance for melphalan/elimusertib combination. Transcriptome analysis was used to evaluate the mechanisms of melphalan/elimusertib synergistic effect; deregulation of several carcinogenic pathways (e.g. MYC, mTOR, p53) as well as the activation of vital biological processes were revealed (e.g. DNA repair, apoptosis, hypoxia, interferon gamma). In a CPC genetic mouse model, IA administration of melphalan and elimusertib significantly increased survival. To the best of our knowledge, this work is the first using human CPC cells to identify several prospective combinatorial treatments and it highlights the effectiveness of IA delivery for the treatment of CPC.
TRLS-07. GLOBAL POST-MARKETING SURVEILLANCE DATA FROM PEDIATRIC AND ADULT PATIENTS WITH CENTRAL NERVOUS SYSTEM MALIGNANCIES TREATED WITH TUMOR TREATING FIELDS (TTFIELDS) THERAPY BETWEEN 2011–2022
Authors: Mrugala Maciej M , Shi Wenyin , Iwamoto Fabio , Lukas Rimas V , Palmer Joshua D , Suh John H , Glas Martin
Published: June 2023

BACKGROUND

TTFields are electric fields that exert physical forces to disrupt cellular processes critical for cancer cell viability and tumor progression. TTFields therapy is approved for adults with recurrent (r) and newly diagnosed (nd) glioblastoma (GBM), based on the phase 3 EF-11 (TTFields 200 kHz) and EF-14 studies (TTFields therapy 200 kHz + temozolomide), respectively, which showed clinical benefit without increase in systemic adverse events (AEs). Pediatric patients were not included in the EF-11 and EF-14 studies. Here, we present pediatric safety data from an updated global post-marketing surveillance (PMS) analysis of patients with brain tumors treated with TTFields therapy, over an 11-year timeframe.

METHODS

Unsolicited PMS data from patients with brain tumors who received TTFields therapy from October 2011-March 2022 in North America, Europe, Middle East, Africa, and Japan were included. AEs were categorized using MedDRA version 25.1.

RESULTS

Overall, 25,898 patients were included. Diagnoses were ndGBM (68%), rGBM (26%), anaplastic astrocytoma/oligodendroglioma (4%) and other (2%). Two-thirds of patients were male. The analysis included 93 (0.4%) pediatric/adolescent patients (<18 years). In pediatric patients, 62% experienced ≥1 AE, with 53% related to TTFields therapy; these values were comparable with the overall population (73% and 56%, respectively). The most common treatment-related AEs in pediatric patients were: skin reaction (39%), heat sensation (14%), and headache (12%); and in the overall population were: skin reaction (43%), electric sensation (14%), and heat sensation (12%).

CONCLUSIONS

This long-term, global, real-world data analysis, including pediatric patients with brain tumors, demonstrates a tolerable safety profile of TTFields therapy, consistent with pivotal clinical studies. There were no major differences in AEs between pediatric and adult patients and no new safety signals identified in the pediatric population. Consistent with the overall dataset, most AEs in pediatric patients were localized mild–moderate skin events, which are typically easily managed.
quincy (1838–1848)
Authors: Adams Henry
Published: June 2023

Under the shadow of Boston State House, turning its back on the house of John Hancock,* the little passage called Hancock Avenue runs, or ran, from Beacon Street, skirting the State House grounds, to Mount Vernon Street, on the summit of Beacon...
berlin (1858–1859)
Authors: Adams Henry
Published: June 2023

A fourth child has the strength of his weakness. Being of no great value, he may throw himself away if he, likes, and never be missed. Charles Francis Adams, the father, felt no love for Europe, which, as he and all the world...
diplomacy (1861)
Authors: Adams Henry
Published: June 2023

Hardly a week passed when the newspapers announced that President Lincoln had selected Charles Francis Adams as his Minister to England.* Once more, silently, Henry put Blackstone back on its shelf. As Friar Bacon’s head sententiously announced many centuries before: Time had...
the battle of the rams (1863)
Authors: Adams Henry
Published: June 2023

Minister Adams troubled himself little about what he did not see of an enemy. His son, a nervous animal, made life a terror by seeing too much. Minister Adams played his hand as it came, and seldom credited his opponents with greater intelligence than...
the perfection of human society (1864)
Authors: Adams Henry
Published: June 2023

Minister Adams’S success in stopping the rebel rams fixed his position once for all in English society. From that moment he could afford to drop the character of diplomatist, and assume what, for an American Minister in London, was an exclusive diplomatic advantage, the...
darwinism (1867–1868)
Authors: Adams Henry
Published: June 2023

Politics, diplomacy, law, art, and history had opened no outlet for future energy or effort, but a man must do something, even in Portland Place, when winter is dark and winter evenings are exceedingly long. At that moment Darwin was convulsing society. The geological...
failure (1871)
Authors: Adams Henry
Published: June 2023

Far back in childhood, among its earliest memories, Henry Adams could recall his first visit to Harvard College. He must have been nine years old when on one of the singularly gloomy winter afternoons which beguiled Cambridgeport, his mother drove him out to visit...
twenty years after (1892)
Authors: Adams Henry
Published: June 2023

Once more! this is a story of education, not of adventure! It is meant to help young men—or such as have intelligence enough to seek help—but it is not meant to amuse them. What one did—or did not do—with one’s education, after getting it,...
the height of knowledge (1902)
Authors: Adams Henry
Published: June 2023

America has always taken tragedy lightly. Too busy to stop the activity of their twenty-million-horse-power society, Americans ignore tragic motives that would have overshadowed the Middle Ages; and the world learns to regard assassination as a form of hysteria, and death as neurosis, to...
the abyss of ignorance (1902)
Authors: Adams Henry
Published: June 2023

The years hurried past, and gave hardly time to note their work. Three or four months, though big with change, come to an end before the mind can catch up with it. Winter vanished; spring burst into flower; and again Paris opened its arms,...
vis inertiae (1903)
Authors: Adams Henry
Published: June 2023

Washington was always amusing, but in 1900, as in 1800, its chief interest lay in its distance from New York. The movement of New York had become planetary—beyond control—while the task of Washington, in 1900 as in 1800, was to control it. The success...
the grammar of science (1903)
Authors: Adams Henry
Published: June 2023

Of all the travels made by man since the voyages of Dante, this new exploration along the shores of Multiplicity and Complexity promised to be the longest, though as yet it had barely touched two familiar regions—race and sex. Even within these narrow seas...
vis nova (1903–1904)
Authors: Adams Henry
Published: June 2023

Paris after midsummer is a place where only the industrious poor remain, unless they can get away; but Adams knew no spot where history would be better off, and the calm of the Champs Elysées was so deep that when Mr. de Witte was...
a dynamic theory of history (1904)
Authors: Adams Henry
Published: June 2023

A dynamic theory, like most theories, begins by begging the question: it defines Progress as the development and economy of Forces. Further, it defines force as anything that does, or helps to do work. Man is a force; so is the sun; so...
nunc age (1905)
Authors: Adams Henry
Published: June 2023

Nearly forty years had passed since the ex-private secretary landed at New York with the ex-Ministers Adams and Motley, when they saw American society as a long caravan stretching out towards the plains. As he came up the bay again, November 5,1904, an older...
II
Authors: Joyce James
Published: June 2023

Mr Leopold Bloom ate with relish the inner organs of beasts and fowls. He liked thick giblet soup, nutty gizzards, a stuffed roast heart, liver slices fried with crustcrumbs, fried hencods’ roes. Most of all he liked grilled mutton kidneys which gave to his...
VI
Authors: Woolf Virginia
Published: June 2023

The flames had fairly caught.

‘There’s St Paul’s!’ someone cried.

As the wood caught the city of London was lit up for a second; on the other sides of the fire there were trees. Of the faces which came out fresh and vivid as though...
VII
Authors: Woolf Virginia
Published: June 2023

About this time a firm of merchants having dealings with the East put on the market little paper flowers* which opened on touching water. As it was the custom also to use finger-bowls at the end of dinner, the new discovery was...
IX
Authors: Woolf Virginia
Published: June 2023

The Countess of Rocksbier sat at the head of the table alone with Jacob. Fed upon champagne and spices for at least two centuries (four, if you count the female line), the Countess Lucy looked well fed. A discriminating nose she had for scents,...
XI
Authors: Woolf Virginia
Published: June 2023

‘Archer’, said Mrs Flanders with that tenderness which mothers so often display towards their eldest sons, ‘will be at Gibraltar tomorrow.’

The post for which she was waiting (strolling up Dods Hill while the random church bells swung a hymn tune about her...
In the Opera Box
Authors: Orczy Baroness
Published: June 2023

It was one of the gala nights at Covent Garden Theatre, the first of the autumn season in this memorable year of grace 1792.

The house was packed, both in the smart orchestra boxes and the pit, as well as in the more plebeian balconies...
Lord Grenville’s Ball
Authors: Orczy Baroness
Published: June 2023

The historic ball given by the then Secretary of State for Foreign Affairs—Lord Grenville—was the most brilliant function of the year. Though the autumn season had only just begun, everybody who was anybody had contrived to be in London in time to be present...
The Friend
Authors: Orczy Baroness
Published: June 2023

Less than half an hour later, Marguerite, buried in thoughts, sat inside her coach, which was bearing her swiftly to London.

She had taken an affectionate farewell of little Suzanne, and seen the child safely started with her maid, and in her own coach, back...
Calais
Authors: Orczy Baroness
Published: June 2023

The weariest nights, the longest days, sooner or later must perforce come to an end.

Marguerite had spent over fifteen hours in such acute mental torture as well-nigh drove her crazy. After a sleepless night, she rose early, wild with excitement, dying to start on...
The Eagle and the Fox
Authors: Orczy Baroness
Published: June 2023

Marguerite’s breath stopped short; she seemed to feel her very life standing still momentarily whilst she listened to that voice and to that song. In the singer she had recognized her husband. Chauvelin, too, had heard it, for he darted a quick glance towards...
The Escape
Authors: Orczy Baroness
Published: June 2023

Marguerite listened—half-dazed as she was—to the fast-retreating, firm footsteps of the four men.

All nature was so still that she, lying with her ear close to the ground, could distinctly trace the sound of their tread, as they ultimately turned into the road, and presently...
TRACKING; or, Noticing and Reading the meaning of small Signs.—Camp Fire Yarns on Observation—Spooring—Reading ‘Sign’
Authors: Baden-Powell Robert
Published: June 2023

Camp Fire Yarn.—No. 5

Observation of ‘Sign’

Noticing ‘sign’—Details of People—Sign round a dead body—Details in the Country—Use of eyes, ears, and nose by Scouts—Night Scouting—Hints to Instructors—Practices and Games in Observation—Books on Observation.

Noticing Sign

‘Sign’ is the word used by scouts...
WOODCRAFT; or, Knowledge of Animals and Nature
Authors: Baden-Powell Robert
Published: June 2023

Camp Fire Yarn.—No. 8

Stalking

As an aid to Observation—How to hide yourself—How to learn Stalking—Games—Book on Stalking.

At some manœuvres lately, two hostile patrols of soldiers were approaching, looking for each other, till the ground between them became very open, and it seemed...
Campaigning
Authors: Baden-Powell Robert
Published: June 2023

Camp Fire Yarn.—No. 14

Life in the Open

Outdoor Training—Exploration—Boat Cruising—Watermanship —Mountaineering—Patrolling—Nightwork—Weather Wisdom.

The native boys of the Zulu and Swazi tribes learn to be scouts before they are allowed to be considered men, and they do it in this way: when a boy...
SAVING LIFE; or, How to Deal with Accidents
Authors: Baden-Powell Robert
Published: June 2023

Camp Fire Yarn.—No. 23

Be Prepared for Accidents

The Knights Hospitallers of St John—Boy Heroes and Girl Heroines—Life-Saving Medals.

Hints to Instructors

The subjects in this chapter should not only be explained to the scouts, but should also, wherever possible, be demonstrated practically, and should...
PATRIOTISM; or, Our Duties as Citizens
Authors: Baden-Powell Robert
Published: June 2023

Camp Fire Yarn.—No. 26

Our Empire

How it Grew—How it Must be Held.

Hints to Instructors

The use of a large Map of the Empire is very desirable for illustrating this. The Arnold-Forster* or the Navy League or the League of the Empire Map...
Kew Gardens and Other Short Fiction
Authors: Woolf Virginia
Published: June 2023

Virginia Woolf’s short fiction has long been acknowledged as the place where she tried out some of her more experimental techniques before adopting and adapting them for use in her novel-length works. While this is certainly true, it is also the case that these short pieces are now increasingly being recognized as important works of art in their own right, rather than simply flights of experimental fancy awaiting their full actualization in the novel form.

This new edition edited by Bryony Randall emphasises the startling variety in Woolf’s experimentation during the most productive period of short fiction writing in Woolf’s life, the late 1910s through to the end of the 1920s. It draws readers’ attention to the deep political engagements evident across the range of her work and on the recent burgeoning of work in modernist print culture to set out the importance of the material context of these works’ initial publication and reception.
The Mark on the Wall
Authors: Woolf Virginia
Published: June 2023

Perhaps it was the middle of January in the present year that I first looked up and saw the mark on the wall. In order to fix a date it is necessary to remember what one saw. So now I think of the fire;...
A Haunted House
Authors: Woolf Virginia
Published: June 2023

Whatever hour you woke there was a door shutting. From room to room they went, hand in hand, lifting here, opening there, making sure — a ghostly couple.

‘Here we left it,’ she said. And he added, ‘Oh, but here too!’ ‘It’s upstairs,’ she murmured. ‘And in...
A Woman’s College From Outside
Authors: Woolf Virginia
Published: June 2023

The feathery-white moon never let the sky grow dark; all night the chestnut blossoms were white in the green, and dim was the cow-parsley in the meadows.* Neither to Tartary* nor to Arabia went the wind of the Cambridge courts, but...
This Side of Paradise
Authors: Fitzgerald F. Scott
Published: June 2023

Following the education and young life of Amory Blaine, from indulged only child to disillusioned war veteran, This Side of Paradise is a thinly veiled account of Fitzgerald’s time as a Princeton undergraduate and an aspiring writer set against the turbulent background of adolescence, first loves, and the outbreak of World War I. Amory moves through a dynamic whirl of exuberant youth, university escapades and adventures home and abroad as one of a new, restless American generation.

This Side of Paradise ensured immediate fame as well as notoriety for F. Scott Fitzgerald. Not only Fitzgerald’s bestselling novel during his lifetime, it was also the work against which each of his later novels was measured. It is impossible to overestimate the importance of This Side of Paradise: without it, the writing career of one of the twentieth-century’s most popular novelists would have been immeasurably different. Brilliant and original in style and structure, brimful of literary experimentalism and fearless originality, it was a spectacular launching for Fitzgerald’s career, and instantly stamped him as the bard of the Jazz Age.
Spires and Gargoyles
Authors: Fitzgerald F. Scott
Published: June 2023

At first Amory noticed only the wealth of sunshine creeping across the long, green swards, dancing on the leaded window-panes, and swimming around the tops of spires and towers and battlemented walls. Gradually he realized that he was really walking up University Place, self-conscious...
Narcissus Off Duty
Authors: Fitzgerald F. Scott
Published: June 2023

During Princeton’s transition period, that is, during Amory’s last two years there, while he saw it change and broaden and live up to its Gothic beauty by better means than night parades, certain individuals arrived who stirred it to its plethoric depths. Some of...
Nathaniel Hawthorne
Authors: Hawthorne Nathaniel
Published: June 2023

A young man, named Giovanni Guasconti, came, very long ago, from the more southern region of Italy, to pursue his studies at the University of Padua.* Giovanni, who had but a scanty supply of gold ducats in his pocket, took lodgings...
George Eliot
Authors: Eliot George
Published: June 2023

Give me no light, great Heaven, but such as turns

To energy of human fellowship;

No powers beyond the growing heritage

That makes completer manhood.*
H. G. WELLS
Authors: Wells H. G.
Published: June 2023

There was, until a year ago, a little and very grimy-looking shop near Seven Dials,* over which, in weather-worn yellow lettering, the name of ‘C. Cave, Naturalist and Dealer in Antiquities,’ was inscribed. The contents of its window were curiously variegated. They...
Rudyard Kipling ‘Wireless’
Authors: Kipling Rudyard
Published: June 2023

KASPAR’S SONG IN ‘VARDA’(From the Swedish of Stagnelius)*

*Eyes aloft, over dangerous places, The children follow where Psyche flies,*And, in the sweat of their upturned faces, Slash with a net at the empty skies.So it goes they fall...
Mary E. Wilkins Freeman
Authors: Freeman Mary E. Wilkins
Published: June 2023

My name is Mrs. Elizabeth Jennings. I am a highly respectable woman. I may style myself a gentlewoman, for in my youth I enjoyed advantages. I was well brought up, and I graduated at a young ladies’ seminary. I also married well. My husband...
H. G. Wells
Authors: Wells H. G.
Published: June 2023

Three hundred miles and more from Chimborazo, one hundred from the snows of Cotopaxi, in the wildest wastes of Ecuador’s Andes,* there lies that mysterious mountain valley, cut off from the world of men, the Country of the Blind. Long years ago...
Sir Arthur Conan Doyle
Authors: Doyle Sir Arthur Conan
Published: June 2023

The following narrative was found among the papers of Dr. James Hardcastle, who died of phthisis* on February 4, 1908, at 36, Upper Coventry Flats, South Kensington.* Those who knew him best, while refusing to express an opinion upon this...
Gertrude Barrows Bennett (‘Francis Stevens’)
Authors: Bennett Gertrude Barrows
Published: June 2023

A ‘Different’ Story.

Being the Veracious Tale of an Ancient Mariness,* Heard and Reported in the Year A. D. 2100

It was upon the water-front that I first met her, in one of the shabby little tea shops frequented by able sailoresses of...
The Beautiful and Damned
Authors: Fitzgerald F. Scott
Published: June 2023

The victor belongs to the spoils.

 — Anthony Patch.

TO

SHANE LESLIE, GEORGE JEAN NATHAN

AND MAXWELL PERKINS*

in appreciation of much literary help

and encouragement
ANTHONY PATCH
Authors: Fitzgerald F. Scott
Published: June 2023

In 1913, when Anthony Patch was twenty-five, two years were already gone since irony, the Holy Ghost of this later day, had, theoretically at least, descended upon him. Irony was the final polish of the shoe, the ultimate dab of the clothes-brush, a sort...
THE CONNOISSEUR OF KISSES
Authors: Fitzgerald F. Scott
Published: June 2023

From his undergraduate days as editor of The Harvard Crimson* Richard Caramel had desired to write. But as a senior he had picked up the glorified illusion that certain men were set aside for “service” and, going into the world, were to...
SYMPOSIUM
Authors: Fitzgerald F. Scott
Published: June 2023

Gloria had lulled Anthony’s mind to sleep. She, who seemed of all women the wisest and the finest, hung like a brilliant curtain across his doorways, shutting out the light of the sun. In those first years what he believed bore invariably the stamp...
A MATTER OF CIVILIZATION
Authors: Fitzgerald F. Scott
Published: June 2023

At a frantic command from some invisible source, Anthony groped his way inside. He was thinking that for the first time in more than three years he was to remain longer than a night away from Gloria. The finality of it appealed to him...
The Enchanted April
Authors: von Arnim Elizabeth
Published: June 2023

Four very different women—the dishevelled and downtrodden Mrs Wilkins, the sad, sweet-faced Mrs Arbuthnot, the formidable widow Mrs Fisher, and the ravishing socialite Lady Caroline Dester—are drawn to the shores of the Mediterranean that April. As each, in turn, blossoms in the warmth of the Italian spring and finds their spirits stirring, quite unexpected changes occur.

The Enchanted April (1922) is a deceptive and timely novel immured in a post-war context, a period noted for its wistful and sometimes satiric writings. Von Arnim's novel is part of this oeuvre and portrays an escape to a carefully described pastoral enclave away from encroaching urbanisation and the spread of new technologies, in an era when the Great War had left many emotionally and physically starved. The journey to San Salvatore by four unhappy women is an escape from stifling parochialism, constraining social and gendered expectations as well as stultifying insularity, but the evocation of an extraordinarily aesthetic and 'enchanted' location suggests more than personal recuperation.
1
Authors: Arnim Elizabeth Von
Published: June 2023

It began in a woman’s club in London on a February afternoon — an uncomfortable club, and a miserable afternoon — when Mrs. Wilkins, who had come down from Hampstead to shop and had lunched at her club, took up The Times from the table in...
5
Authors: Arnim Elizabeth Von
Published: June 2023

It was cloudy in Italy, which surprised them. They had expected brilliant sunshine. But never mind: it was Italy, and the very clouds looked fat. Neither of them had ever been there before. Both gazed out of the windows with rapt faces. The hours...
9
Authors: Arnim Elizabeth Von
Published: June 2023

That one of the two sitting-rooms which Mrs. Fisher had taken for her own was a room of charm and character. She surveyed it with satisfaction on going into it after breakfast, and was glad it was hers. It had a tiled floor, and...
10
Authors: Arnim Elizabeth Von
Published: June 2023

There was no way of getting into or out of the top garden at San Salvatore except through the two glass doors, unfortunately side by side, of the dining-room and the hall. A person in the garden who wished to escape unseen could not,...
11
Authors: Arnim Elizabeth Von
Published: June 2023

The sweet smells that were everywhere in San Salvatore were alone enough to produce concord. They came into the sitting-room from the flowers on the battlements, and met the ones from the flowers inside the room, and almost, thought Mrs. Wilkins, could be seen...
12
Authors: Arnim Elizabeth Von
Published: June 2023

At the evening meal, which was the first time the whole four sat round the dining-room table together, Scrap appeared.

She appeared quite punctually, and in one of those wrappers or tea-gowns which are sometimes described as ravishing. This one really was ravishing. It certainly...
15
Authors: Arnim Elizabeth Von
Published: June 2023

The strange effect of this incident was that when they met that evening at dinner both Mrs. Fisher and Lady Caroline had a singular feeling of secret understanding with Mr. Wilkins. He could not be to them as other men. He could not be...
16
Authors: Arnim Elizabeth Von
Published: June 2023

And so the second week began, and all was harmony. The arrival of Mr. Wilkins, instead of, as three of the party had feared and the fourth had only been protected from fearing by her burning faith in the effect on him of San...
18
Authors: Arnim Elizabeth Von
Published: June 2023

They had a very pleasant walk, with a great deal of sitting down in warm, thyme-fragrant corners, and if anything could have helped Rose to recover from the bitter disappointment of the morning it would have been the company of Mr. Briggs. He did...
20
Authors: Arnim Elizabeth Von
Published: June 2023

Scrap wanted to know so much about her mother that Arundel had presently to invent. He would talk about anything she wished if only he might be with her for a while and see her and hear her, but he knew very little of...
21
Authors: Arnim Elizabeth Von
Published: June 2023

Now Frederick was not the man to hurt anything if he could help it; besides, he was completely bewildered. Not only was his wife here — here, of all places in the world — but she was clinging to him as she had not clung for years, and...
Second Conversation with the Landlady
Authors: Kafka Franz
Published: June 2023

The landlord was waiting outside the inn for him. He would not have ventured to speak without being asked first, so K. asked what he wanted. ‘Have you found new lodgings?’ asked the landlord, his eyes bent on the ground. ‘I think you must...
Waiting for Klamm
Authors: Kafka Franz
Published: June 2023

At first K. was glad to have escaped the warm room, crowded as it was with the maids and the assistants. It was freezing a little outside, the snow was firmer and walking easier. However, it was beginning to grow dark, so he quickened...
The Assistants
Authors: Kafka Franz
Published: June 2023

As soon as they had all left K. told the assistants: ‘Go away, you two!’ Surprised by this unexpected order, they obeyed, but when K. locked the door behind them they tried to get back in, and stood outside whimpering and knocking. ‘You’re dismissed!’...
22
Authors: Kafka Franz
Published: June 2023

Then, looking aimlessly around, K. saw Frieda in the distance, at a turn in the corridor; she acted as if she didn’t recognize him, and just looked blankly at him. She was carrying a tray of empty dishes. He told the servant, although the...
23
Authors: Kafka Franz
Published: June 2023

Only now did K. notice how quiet it had become in the corridor—not just in this part of the corridor, where he had been standing with Frieda and which seemed to be part of the domestic staff’s quarters, but also in the long corridor...
A Conversation with Frau Grubach Then Fräulein Bürstner
Authors: Kafka Franz
Published: June 2023

During that spring K. used to spend his evenings whenever possible—he generally stayed in the office until nine o’clock—going for a short walk after work by himself or with friends and then to an inn, where he normally sat with some mostly older men...
The First Hearing
Authors: Kafka Franz
Published: June 2023

K. had been informed by telephone that a short hearing in his affair would take place the next Sunday. He was advised that these hearings would now proceed regularly, if not every week perhaps, then certainly at fairly frequent intervals. On the one hand,...
In the Empty Conference Hall The Student ⋅ The Offices
Authors: Kafka Franz
Published: June 2023

During the next week K. waited daily for a new appointment. He could not believe they had taken his rejection of hearings literally, and when the expected notification had not arrived by Saturday evening, he assumed there was a tacit summons to be in...
The Lawyer ⋅ The Factory-Owner ⋅ The Painter
Authors: Kafka Franz
Published: June 2023

One winter’s morning—outside snow was falling in the murky light—K. was in his office, feeling extremely tired already despite the early hour. In order to prevent himself from at least being disturbed by the clerks, he’d told the messenger not to let any of...
B.’s Friend
Authors: Kafka Franz
Published: June 2023

In the days that followed K. found it impossible to speak to Fräulein Bürstner at all, even to exchange a few words with her. He tried all sorts of different ways of approaching her, but she always managed to avoid contact with him. He...
The Fight with the Deputy Manager
Authors: Kafka Franz
Published: June 2023

One morning K. felt much fresher and more robust than usual. He scarcely thought of the court at all, but when he did so, it seemed to him that there was some place where, even though he would have to feel for it in...
The Judgement
Authors: Kafka Franz
Published: June 2023

It was on a Sunday morning, when spring was at its best. Georg Bendemann,* a young businessman, was sitting in his own room on the first floor of one of the low, flimsily-built houses extending in a long row down the riverside,...
Meditation
Authors: Kafka Franz
Published: June 2023

Children on the Highway

I heard the wagons passing the garden fence; sometimes I caught sight of them through the gaps made by the gentle stirring of the leaves. How the wood of their spokes and shafts creaked in the summer heat! Workmen...
Chapter IV
Authors: Conrad Joseph
Published: June 2023

A month or so afterwards, when Jim, in answer to pointed questions, tried to tell honestly the truth of this experience, he said, speaking of the ship: “She went over whatever it was as easy as a snake crawling over a stick.” The illustration...
Chapter XI
Authors: Conrad Joseph
Published: June 2023

“He heard me out with his head on one side, and I had another glimpse through a rent in the mist in which he moved and had his being. The dim candle spluttered within the ball of glass, and that was all I...
Chapter XII
Authors: Conrad Joseph
Published: June 2023

“All around everything was still as far as the ear could reach. The mist of his feelings shifted between us, as if disturbed by his struggles, and in the rifts of the immaterial veil he would appear to my staring eyes distinct of...
Chapter XV
Authors: Conrad Joseph
Published: June 2023

“I did not start in search of Jim at once, only because I had really an appointment which I could not neglect. Then, as ill-luck would have it, in my agent’s office I was fastened upon by a fellow fresh from Madagascar with...
Chapter XVIII
Authors: Conrad Joseph
Published: June 2023

“Six months afterwards my friend (he was a cynical, more than middle-aged bachelor, with a reputation for eccentricity, and owned a rice-mill) wrote to me, and judging, from the warmth of my recommendation, that I would like to hear, enlarged a little upon...
Chapter XIX
Authors: Conrad Joseph
Published: June 2023

“I have told you these two episodes at length to show his manner of dealing with himself under the new conditions of his life. There were many others of the sort, more than I could count on the fingers of my two hands....
Chapter XXI
Authors: Conrad Joseph
Published: June 2023

“I don’t suppose any of you had ever heard of Patusan?” Marlow resumed, after a silence occupied in the careful lighting of a cigar. “It does not matter; there’s many a heavenly body in the lot crowding upon us of a night that...
Chapter XXII
Authors: Conrad Joseph
Published: June 2023

“The conquest of love, honour, men’s confidence—the pride of it, the power of it, are fit materials for a heroic tale; only our minds are struck by the externals of such a success, and to Jim’s successes there were no externals. Thirty miles...
Chapter XXV
Authors: Conrad Joseph
Published: June 2023

“ ‘This is where I was prisoner for three days,’ he murmured to me (it was on the occasion of our visit to the Rajah), while we were making our way slowly through a kind of awestruck riot of dependants across Tunku Allang’s...
Chapter XXVI
Authors: Conrad Joseph
Published: June 2023

“Doramin was one of the most remarkable men of his race I had ever seen. His bulk for a Malay was immense, but he did not look merely fat; he looked imposing, monumental. This motionless body clad in rich stuffs, coloured silks, gold...
Chapter XXX
Authors: Conrad Joseph
Published: June 2023

“He told me further that he didn’t know what made him hang on—but of course we may guess. He sympathised deeply with the defenceless girl, at the mercy of that ‘mean, cowardly scoundrel.’ It appears Cornelius led her an awful life, stopping only...
Chapter XXXI
Authors: Conrad Joseph
Published: June 2023

“You may imagine with what interest I listened. All these details were perceived to have some significance twenty-four hours later. In the morning Cornelius made no allusion to the events of the night. ‘I suppose you will come back to my poor house,’...
Chapter XXXII
Authors: Conrad Joseph
Published: June 2023

“Jim took up an advantageous position and shepherded them out in a bunch through the doorway: all that time the torch had remained vertical in the grip of a little hand, without so much as a tremble. The three men obeyed him, perfectly...
Chapter XXXIII
Authors: Conrad Joseph
Published: June 2023

“I was immensely touched: her youth, her ignorance, her pretty beauty, which had the simple charm and the delicate vigour of a wild-flower, her pathetic pleading, her helplessness, appealed to me with almost the strength of her own unreasonable and natural fear. She...
Chapter XLII
Authors: Conrad Joseph
Published: June 2023

“I don’t think he could do more than perhaps look upon that straight path. He seemed to have been puzzled by what he saw, for he interrupted himself in his narrative more than once to exclaim, ‘He nearly slipped from me there. I...
Chapter XLIII
Authors: Conrad Joseph
Published: June 2023

“Tamb’ Itam behind his chair was thunderstruck. The declaration produced an immense sensation. ‘Let them go because this is best in my knowledge, which has never deceived you,’ Jim insisted. There was a silence. In the darkness of the courtyard could be heard...
Chapter XLV
Authors: Conrad Joseph
Published: June 2023

“When Tamb’ Itam, paddling madly, came into the town-reach, the women, thronging the platforms before the houses, were looking out for the return of Dain Waris’s little fleet of boats. The town had a festive air; here and there men, still with spears...
Of Mr. Booker T. Washington and Others
Authors: Du Bois W. E. B.
Published: June 2023

From birth till death enslaved; in word, in deed, unmanned!

.   .   .   .   .   .   .   .   .

Hereditary bondsmen! Know ye not

Who would be free themselves must strike the blow?

Easily the most striking thing in the history of the American Negro since 1876 is...
CHAPTER III
Authors: Fitzgerald F. Scott
Published: June 2023

There was music from my neighbor’s house through the summer nights. In his blue gardens men and girls came and went like moths among the whisperings and the champagne and the stars. At high tide in the afternoon I watched his guests diving from...
CHAPTER IV
Authors: Fitzgerald F. Scott
Published: June 2023

On Sunday morning while church bells rang in the villages alongshore, the world and its mistress returned to Gatsby’s house and twinkled hilariously on his lawn.

“He’s a bootlegger,” said the young ladies, moving somewhere between his cocktails and his flowers. “One time he killed...
CHAPTER V
Authors: Fitzgerald F. Scott
Published: June 2023

When I came home to West Egg that night I was afraid for a moment that my house was on fire. Two o’clock and the whole corner of the peninsula was blazing with light, which fell unreal on the shrubbery and made thin elongating...