bluuebunny/crossref_metadata_2025 huggingface dataset:
Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells
Authors: Oscilowska Ilona , Huynh Thi Y. L. , Baszanowska Weronika , Prokop Izabela , Surazynski Arkadiusz , Galli Mauro , Zabielski Piotr , Palka Jerzy
Published: June 2021

Proline oxidase (POX) is mitochondrial proline-degrading enzyme of dual apoptosis/survival function. POX expression and proline availability are considered an underlying mechanism for differential POX functions. The mechanism for POX-dependent regulation of cell death/survival was studied in wild-type (MCF-7WT) and shRNA POX-silenced breast cancer cells (MCF-7iPOX). Proline concentration and proteomic analyses were determined by LC/MS/QTOF and LC/MS/ORBITRA, respectively. Inhibition of collagen biosynthesis (proline utilizing process) by 2-methoxyestradiol (2ME) contributed to induction of apoptosis in MCF-7WT cells, as detected by increase in the expression of active caspase-3, -9 and p53. The process was not shown in MCF-7iPOX. In MCF-7iPOX cells prolidase activity and expression as well as proline concentration were drastically increased, compared to MCF-7WT cells. Down-regulation of p53 in MCF-7iPOX cells was corroborated by proteomic analysis showing decrease in the expression of p53-related proteins. The mechanism for down-regulation of p53 expression in MCF-7iPOX cells was found at the level of p53–PEPD complex formation that was counteracted by hydrogen peroxide treatment. In this study, we found that silencing POX modulate pro-survival phenotype of MCF-7 cells and suggest that the mechanism of this process undergoes through down-regulation of p53-dependent signaling.
Effect of tolvaptan in Japanese patients with autosomal dominant polycystic kidney disease: a post hoc analysis of TEMPO 3:4 and TEMPO Extension Japan
Authors: Muto Satoru , Okada Tadashi , Shibasaki Yoshiyuki , Ibuki Tatsuki , Horie Shigeo
Published: June 2021

Background

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive condition that eventually leads to end-stage renal disease. A phase 3 trial of tolvaptan (TEMPO 3:4; NCT00428948) and its open-label extension (TEMPO Extension Japan: TEMPO-EXTJ; NCT01280721) were conducted in patients with ADPKD. In this post hoc analysis, effects on renal function and the safety profile of tolvaptan were assessed over a long-term period that included the 3-year TEMPO 3:4 and the approximately 3-year TEMPO-EXTJ trials.

Methods

Patients from Japanese trial sites who completed TEMPO 3:4 were offered participation in TEMPO-EXTJ. Patients whose efficacy parameters were measured at year 2 in TEMPO-EXTJ for efficacy evaluation were included. The annual slope of the estimated glomerular filtration rate (eGFR) and growth in total kidney volume (TKV) were analyzed.

Results

In patients who received tolvaptan in TEMPO 3:4 and TEMPO-EXTJ, the annual slope of eGFR (mL/min/1.73 m2) was − 3.480 in TEMPO 3:4 and − 3.417 in TEMPO-EXTJ, with no apparent effect of an approximately 3.6-month off-treatment interval between the two trials. In patients who received a placebo in TEMPO 3:4 before initiating tolvaptan in TEMPO-EXTJ, the slope of eGFR was significantly less steep from TEMPO 3:4 (− 4.287) to TEMPO-EXTJ (− 3.364), a difference of 0.923 (P = 0.0441).

Conclusion

The TEMPO-EXTJ trial supports a sustained beneficial effect of tolvaptan on eGFR. In patients who received a placebo in TEMPO 3:4, initiation of tolvaptan in TEMPO-EXTJ was associated with a significant slowing of eGFR decline.
Effect of non-native species on taxonomic and functional diversity of fish communities in different river types
Authors: Takács Péter , Abonyi András , Bánó Bálint , Erős Tibor
Published: June 2021

Recent researches suggest that functional diversity represents the response of communities to environmental alterations better than taxonomic diversity. However, there is scarce information about how the functional diversity of freshwater fishes is affected by habitat type and the dominance of non-native species. To address this question, we analysed a large database containing 15 morpho-functional traits of 61 fish species from the Pannon Biogeographic region (Hungary). Based on a fish faunistic list and relative abundance of taxa, we quantified the taxonomic and functional diversity of riverine communities for > 700 sites of six habitat types. We asked how non-native fishes affected the taxonomic and functional diversity in different river types and at the local scale (i.e. at the site level), and how the diversity measures of native fauna elements changes along the invasion gradient. Our results showed that both functional and taxonomic richness increases with habitat complexity, from small headwater streams to large rivers. Therefore taxonomic diversity served as a good proxy for functional diversity along the environmental gradient of river types. Non-natives showed considerable functional diversity relative to their species number in each habitat type. Diversity values of native fauna elements initially increased, and then showed a major decrease along the invasion gradient. River type-specific evaluations highlighted the importance of considering the proliferation of invasive species based on both taxonomic and functional diversity indices. We argue that type-specific action plans are needed in conservation management to preserve the taxonomic and functional diversity of native fishes in Hungary, but also elsewhere.
Thalamocortical Spectral Transmission Relies on Balanced Input Strengths
Authors: Saponati Matteo , Garcia-Ojalvo Jordi , Cataldo Enrico , Mazzoni Alberto
Published: June 2021

The thalamus is a key element of sensory transmission in the brain, as it gates and selects sensory streams through a modulation of its internal activity. A preponderant role in these functions is played by its internal activity in the alpha range ([8–14] Hz), but the mechanism underlying this process is not completely understood. In particular, how do thalamocortical connections convey stimulus driven information selectively over the back-ground of thalamic internally generated activity? Here we investigate this issue with a spiking network model of feedforward connectivity between thalamus and primary sensory cortex reproducing the local field potential of both areas. We found that in a feedforward network, thalamic oscillations in the alpha range do not entrain cortical activity for two reasons: (i) alpha range oscillations are weaker in neurons projecting to the cortex, (ii) the gamma resonance dynamics of cortical networks hampers oscillations over the 10–20 Hz range thus weakening alpha range oscillations. This latter mechanism depends on the balance of the strength of thalamocortical connections toward excitatory and inhibitory neurons in the cortex. Our results highlight the relevance of corticothalamic feedback to sustain alpha range oscillations and pave the way toward an integrated understanding of the sensory streams traveling between the periphery and the cortex.
Usefulness of a multiparametric evaluation including global longitudinal strain for an early diagnosis of acute myocarditis
Authors: Degiovanni Anna , Pastore Maria Concetta , Spinoni Enrico Guido , Focardi Marta , Cameli Matteo , Patti Giuseppe
Published: June 2021

Cardiac magnetic resonance imaging (CMRI) represents the main imaging modality for diagnosing acute myocarditis. However, its limited availability could entail missing or delayed diagnosis. A reduction of left ventricular global longitudinal strain (LV GLS) by speckle tracking echocardiography (STE) correlates with amount of oedema in acute myocarditis and here may be early detected. Aim was to evaluate the diagnostic and prognostic role of 3-layers LV GLS in patients with acute myocarditis. Out of 122 patients with suspected acute myocarditis, a total of 86 consecutive patients with CMRI-confirmed acute myocarditis admitted in two Italian institutions were retrospectively screened. Exclusion criteria were met in 29 patients because of poor acoustic window or missing data. A total of 57 patients were then included. Clinical characteristics, laboratory examinations, transthoracic echocardiography data and STE parameters were collected early after hospitalization. In the study population, mean age was 38.8 ± 15.6 years, the prevalence of male gender was 90%. On admission, 22 patients (39%) had fever (body temperature > 37.5 °), mean white blood cell (WBC) count was 10.9 ± 1.7/10^3 and overall LV ejection fraction was 50.1% ± 11.2. An epicardial LV GLS < 18% was present in 74% of patients, and a model including at least one of LV GLS < 18% (absolute value), fever and WBC > 10.0/10^3 was able to identify all patients with CMRI-diagnosed acute myocarditis. An epicardial LV GLS < 15.3% (absolute value) at baseline significantly predicted the lack of myocarditis resolution during follow-up (AUC 0.76, 95% CI 0.58–0.93, p = 0.02). A multiparametric model including epicardial LV GLS, fever and elevated WBC count on admission could be useful for early diagnosing an acute myocarditis, especially when CMRI is not promptly available. Baseline epicardial LV GLS may also identify patients with less-likely myocarditis resolution.
Smart sheet metal forming: importance of data acquisition, preprocessing and transformation on the performance of a multiclass support vector machine for predicting wear states during blanking
Authors: Kubik Christian , Knauer Sebastian Michael , Groche Peter
Published: June 2021

In consequence of high cost pressure and the progressive globalization of markets, blanking, which represents the most economical process in the value chain of manufacturing companies, is particularly dependent on reducing machine downtimes and increasing the degree of utilization. For this purpose, it is necessary to be able to make a real-time prediction about the current and future process conditions even at high production rates. Therefore, this study investigates the influence of data acquisition, preprocessing and transformation on the performance of a multiclass support vector machine to classify abrasive wear states during blanking based on force signals. The performance of the model was quantitatively evaluated based on the model accuracy and the separability of the classes. As a result, it was shown, that the deviation of time series represents the key parameter for the resulting performance of the classification model and strongly depends on the sensor type and position, the preprocessing procedure as well as the feature extraction and selection. Furthermore, it is shown that the consideration of domain knowledge in the phases of data acquisition, preprocessing and transformation improves the performance of the classification model and is essential to successfully implement AI projects. Summarizing the findings of this study, trustworthy data sets play a crucial role for implementing an automated process monitoring as a basis for resilient manufacturing systems.
Formally-based Model-Driven Development of Collaborative Robotic Applications
Authors: Askarpour Mehrnoosh , Lestingi Livia , Longoni Samuele , Iannacci Niccolò , Rossi Matteo , Vicentini Federico
Published: June 2021

The development of Human Robot Collaborative (HRC) systems faces many challenges. First, HRC systems should be adaptable and re-configurable to support fast production changes. However, in the development of HRC applications safety considerations are of paramount importance, as much as classical activities such as task programming and deployment. Hence, the reconfiguration and reprogramming of executing tasks might be necessary also to fulfill the desired safety requirements. Model-based software engineering is a suitable means for agile task programming and reconfiguration. We propose a model-based design-to-deployment toolchain that simplifies the routine of updating or modifying tasks. This toolchain relies on (i) UML profiles for quick model design, (ii) formal verification for exhaustive search for unsafe situations (caused by intended or unintended human behavior) within the model, and (iii) trans-coding tools for automating the development process. The toolchain has been evaluated on a few realistic case studies. In this paper, we show a couple of them to illustrate the applicability of the approach.
Transporting Deformations of Face Emotions in the Shape Spaces: A Comparison of Different Approaches
Authors: Piras Paolo , Varano Valerio , Louis Maxime , Profico Antonio , Durrleman Stanley , Charlier Benjamin , Milicchio Franco , Teresi Luciano
Published: June 2021

Studying the changes of shape is a common concern in many scientific fields. We address here two problems: (1) quantifying the deformation between two given shapes and (2) transporting this deformation to morph a third shape. These operations can be done with or without point correspondence, depending on the availability of a surface matching algorithm, and on the type of mathematical procedure adopted. In computer vision, the re-targeting of emotions mapped on faces is a common application. We contrast here four different methods used for transporting the deformation toward a target once it was estimated upon the matching of two shapes. These methods come from very different fields such as computational anatomy, computer vision and biology. We used the large diffeomorphic deformation metric mapping and thin plate spline, in order to estimate deformations in a deformational trajectory of a human face experiencing different emotions. Then we use naive transport (NT), linear shift (LS), direct transport (DT) and fanning scheme (FS) to transport the estimated deformations toward four alien faces constituted by 240 homologous points and identifying a triangulation structure of 416 triangles. We used both local and global criteria for evaluating the performance of the 4 methods, e.g., the maintenance of the original deformation. We found DT, LS and FS very effective in recovering the original deformation while NT fails under several aspects in transporting the shape change. As the best method may differ depending on the application, we recommend carefully testing different methods in order to choose the best one for any specific application.
Trends of out-mobility from large housing estates in Stockholm: influences of the housing policy and neighbourhood context
Authors: Kadarik Kati , Kährik Anneli
Published: June 2021

Since 1990s Stockholm housing market has seen deregulations in accordance with liberalization trends in other European welfare states. The new governance principles together with increasing immigration and public rental housing conversions into cooperative housing in attractive inner city areas have put pressure on still rental-dominated estates because fewer rental dwellings must now cater to expanding numbers of people who have little choice on the housing market. In recent decades, many estates have displayed increasing signs of stigmatization, social exclusion, and outflow of relatively affluent people. This paper improves our knowledge of how the housing policy and economic changes have affected out-mobility from the housing estates in case of three cohorts of young people and how the childhood neighbourhood conditions affect this. Individual annual Swedish registry data (1990–2014) are employed to longitudinally study the out-mobility patterns of three cohorts that grew up in the estates against the backdrop of marketization, growing inequality and deteriorating conditions. This study supplements the existing literature on housing estates by clarifying how income has become more and ethnicity less important over time in explaining sorting patterns from these estates. However, the combination of the two has determined sorting throughout the study period. Growing up in a higher socioeconomic status neighbourhood had modest impact on reducing socioeconomic differences in out-mobility from the estates, while leading to more sorting based on ethnic background.
A New Generalized Variance Approach for Measuring Multidimensional Inequality and Poverty
Authors: Hajdu Ottó
Published: June 2021

The paper suggests a new generalized variance concept for measuring multidimensional inequality of a stratified society, based on multivariate statistical methods, where the members of society form a cloud in the oblique space of dimensions of inequality, such as income, expenditure and property. The cloud presents the multidimensional inequality capsulized in the cloud. The goal is to condense all the inequality information embodied by the cloud into a composite compact metric characterizing both the shape and the inner structure of the cloud. Contrary to the conventional literature that considers multidimensionality as a unidimensional weighted combination of the dimensions, our new composite index measures the inequality of the configuration of the points in the cloud. Our aim is twofold. First, we introduce the Inequality Covariance Matrix (ICM) assigned to the cloud, with elements measuring the correlations among dimensions. Having ICM, we propose the Generalized Variance (GV) of ICM to measure the composite Generalized Variance Inequality (GVI) level. Second, to evaluate the stratum-specific structure of the overall inequality, we suggest a new two-stage procedure. In the first stage, we divide the total GVI into between-groups and within-groups effects. Then, in the second stage the contributions of the strata to the within-groups inequality and, the contributions of the dimensions to the between-groups inequality are calculated. This GVI approach is sensitive to the correlation system, decomposable into stratum effects and, the number of dimensions is not limited. Moreover, including the log-dimensions in the analysis, GVI yields an Entropy Covariance Matrix giving a new Generalized Variance Entropy index. Finally, the GVI of censored poverty indicators means multidimensional poverty measurement. This special complex task is not yet solved in the traditional literature so far.
The key to the knowledge norm of action is ambiguity
Authors: Rich Patricia
Published: June 2021

Knowledge-first epistemology includes a knowledge norm of action: roughly, act only on what you know. This norm has been criticized, especially from the perspective of so-called standard decision theory. Mueller and Ross provide example decision problems which seem to show that acting properly cannot require knowledge. I argue that this conclusion depends on applying a particular decision theory (namely, Savage-style Expected Utility Theory) which is ill-motivated in this context. Agents’ knowledge is often most plausibly formalized as an ambiguous epistemic state, and the theory of decision under ambiguity is then the appropriate modeling tool. I show how to model agents as acting rationally on the basis of their knowledge according to such a theory. I conclude that the tension between the knowledge norm of action and formal decision theory is illusory; the knowledge-first paradigm should be used to actively select the decision-theoretical tools that can best capture the knowledge-based decisions in any given situation.
Coordination in theory extension: how Reichenbach can help us understand endogenization in evolutionary biology
Authors: Luchetti Michele
Published: June 2021

Reichenbach’s early solution to the scientific problem of how abstract mathematical representations can successfully express real phenomena is rooted in his view of coordination. In this paper, I claim that a Reichenbach-inspired, ‘layered’ view of coordination provides us with an effective tool to systematically analyse some epistemic and conceptual intricacies resulting from a widespread theorising strategy in evolutionary biology, recently discussed by Okasha (2018) as ‘endogenization’. First, I argue that endogenization is a form of extension of natural selection theory that comprises three stages: quasi-axiomatisation, functional extension, and semantic extension. Then, I argue that the functional extension of one core principle of natural selection theory, namely, the principle of heritability, requires the semantic extension of the concept of inheritance. This is because the semantic extension of ‘inheritance’ is necessary to establish a novel form of coordination between the principle of heritability and the extended domain of phenomena that it is supposed to represent. Finally, I suggest that—despite the current lack of consensus on the right semantic extension of ‘inheritance’—we can fruitfully understand the reconceptualization of ‘inheritance’ provided by niche construction theorists as the result of a novel form of coordination.
Correction to: Positive effect of AgNPs and AuNPs in in vitro cultures of Lavandula angustifolia Mill.
Authors: Jadczak Paula , Kulpa Danuta , Bihun Magdalena , Przewodowski Włodzimierz
Published: June 2021

A correction to this paper has been published: https://doi.org/10.1007/s11240-021-02087-2
Treatment with sera from Water Polo athletes activates AMPKα and ACC proteins In HepG2 hepatoma cell line
Authors: Polito Rita , Monaco Maria Ludovica , Mallardo Marta , Elce Ausilia , Daniele Aurora , Nigro Ersilia
Published: June 2021

Purpose

Physical activity and professional physical activity such as water polo (WP) sport, has numerous beneficial effects to fight metabolism-related disorders through several mechanisms, including the promotion of liver metabolic adaptations, and the modulation of cytokine production. The aim of this study was to investigate the effects of different types of physical activity on AMPKα and ACC, two proteins involved in liver metabolism; therefore, we treated the hepatoma cell line Hep G2 with sera from elite WP athletes and amateur (basket) players. As control, we used serum from both sedentary and obese subjects.

Methods

Help G2 cells were treated with 5% of human sera from the different subjects; after 24 h and 48 h, HepG2 cell viability was verified through MTT assay and activation status of AMPKα and ACC through western blotting. Cytokine’s serum levels were measured through ELISA assay.

Results

After 72 h, the treatment of HepG2 cells with sera from the different subjects produced no effect on cell viability. Furthermore, after 48 h of treatment, both AMPKα and ACC phosphorylation statistically increases in HepG2 cells treated with sera from WP athletes. Furthermore, IL-4, IL-6 and IL-10 levels resulted statistically increased in WP athlete’s sera than in sedentary subjects.

Conclusion

The specific activation of AMPKα and ACC by WP sera confirms that professional sport activity carried out by WP athletes can be considered as a physiological activator of these two proteins also in HepG2 liver cells. In addition, the increase of anti-inflammatory cytokines in WP sera confirms the ample evidence for multiple anti-inflammatory activities carried out by WP discipline.
Revisiting the dynamic interactions between economic growth and environmental pollution in Italy: evidence from a gradient descent algorithm
Authors: Mele Marco , Magazzino Cosimo , Schneider Nicolas , Nicolai Floriana
Published: June 2021

Although the literature on the relationship between economic growth and CO2 emissions is extensive, the use of machine learning (ML) tools remains seminal. In this paper, we assess this nexus for Italy using innovative algorithms, with yearly data for the 1960–2017 period. We develop three distinct models: the batch gradient descent (BGD), the stochastic gradient descent (SGD), and the multilayer perceptron (MLP). Despite the phase of low Italian economic growth, results reveal that CO2 emissions increased in the predicting model. Compared to the observed statistical data, the algorithm shows a correlation between low growth and higher CO2 increase, which contradicts the main strand of literature. Based on this outcome, adequate policy recommendations are provided.
Ensuring the Correctness of Regular Expressions: A Review
Authors: Zheng Li-Xiao , Ma Shuai , Chen Zu-Xi , Luo Xiang-Yu
Published: June 2021

Regular expressions are widely used within and even outside of computer science due to their expressiveness and flexibility. However, regular expressions have a quite compact and rather tolerant syntax that makes them hard to understand, hard to compose, and error-prone. Faulty regular expressions may cause failures of the applications that use them. Therefore, ensuring the correctness of regular expressions is a vital prerequisite for their use in practical applications. The importance and necessity of ensuring correct definitions of regular expressions have attracted extensive attention from researchers and practitioners, especially in recent years. In this study, we provide a review of the recent works for ensuring the correct usage of regular expressions. We classify those works into different categories, including the empirical study, test string generation, automatic synthesis and learning, static checking and verification, visual representation and explanation, and repairing. For each category, we review the main results, compare different approaches, and discuss their advantages and disadvantages. We also discuss some potential future research directions.
Role of Direct Aging and Solution Treatment on Hardness, Microstructure and Residual Stress of the A357 (AlSi7Mg0.6) Alloy Produced by Powder Bed Fusion
Authors: Tonelli Lavinia , Liverani Erica , Morri Alessandro , Ceschini Lorella
Published: June 2021

Applying additive manufacturing (AM) technologies to the fabrication of aluminum automotive components, with an optimized design, may result in improved vehicle light weighting. However, the post-process heat treatment of such alloys has to be customized for the particular AM microstructure. The present study is aimed at investigating the effect of different heat treatments on the microstructure, hardness and residual stress of the A357 (AlSi7Mg0.6) heat-treatable alloy produced by laser-based powder bed fusion (LPBF, also known as selective laser melting). There are two major issues to be addressed: (1) relieving the internal residual stress resulting from the process and (2) strengthening the alloy with a customized heat treatment. Therefore, stress-relief annealing treatment, direct aging of the as-built alloy and a redesigned T6 treatment (consisting of a shortened high-temperature solution treatment followed by artificial aging) were examined. Comparable hardness values were reached in the LPBF alloy with optimized direct aging and T6 treatments, but complete relief of the residual stress was obtained only with T6. Microstructural analyses also suggested that, because of the supersaturated solid solution, different phenomena were involved in direct aging and T6 treatment.
Preparation of ZnO/Nylon 6/6 nanocomposites, their characterization and application in dye decolorization
Authors: Saeed Khalid , Khan Idrees , Ahad Madiha , Shah Tariq , Sadiq Muhammad , Zada Amir , Zada Noor
Published: June 2021

Nylon 6/6 and ZnO/nylon 6/6 nanocomposite films were prepared by solvent casting method. Morphological study displayed that ZnO NPs are better dispersed in nylon 6/6. However, some agglomerations were found by the incorporation of high quantities of fillers. The thermal stabilities of neat nylon 6/6 films decreased by addition of nanoparticles (NPs). DSC study shows that the NPs slow down the crystallization rate of neat polymer matrix. POM of Nylon 6/6 upon crystallization showed distinct sized spherulites, which decreased by the incorporation of NPs because of nucleation effect of NPs. The mechanical properties of neat polymer are decreased by addition of ZnO NPs, which might be due to agglomeration of fillers. The neat nylon 6/6 and ZnO/nylon 6/6 nanocomposite were used for the photodegradation of alizarin red (AR) dye, which shows that pure nylon 6/6 degraded about 28% dye while 30% ZnO/Nylon 6/6 degraded about 58.3% dye within 5 h irradiation.
Correction to: Orthorexic eating behavior and body dissatisfaction in a sample of young females
Authors: Barthels Friederike , Kisser Julia , Pietrowsky Reinhard
Published: June 2021

A correction to this paper has been published: https://doi.org/10.1007/s40519-021-01219-z
Daytime sleepiness underlies the link between adverse parenting and youth psychopathology among adolescent girls
Authors: Sasser Jeri , Oshri Assaf , Duprey Erinn B. , Doane Leah D. , Peltz Jack S.
Published: June 2021

Introduction

Adverse parenting is associated with sleep problems in adolescence, including sleep quality, inadequate sleep, and daytime sleepiness. Adolescents who experience sleep problems are at greater risk for developing internalizing and externalizing problems. However, research on the intervening role of sleep in the link between adverse parenting and youth psychopathology remains limited. The present study aimed to examine the indirect effects of adverse parenting on youth internalizing and externalizing psychopathology via sleep problems, and to examine the moderating role of gender in associations between parenting and sleep.

Methods

Participants were 101 low‐income youth aged 9–12 (52.5% female; 75.2% African‐American) and their primary caregivers. Families were from a non‐metropolitan region in the Southeastern United States. Data were collected at two time points (T1; Mage = 10.28, SD = 1.2; T2; Mage = 12.08, SD = 1.2). Adverse parenting was measured at T1, youth‐reported sleep problems (inadequacy, disturbance) and daytime sleepiness were assessed at T2, and parent‐reported internalizing and externalizing symptoms were measured at T2.

Results

Daytime sleepiness served as an intervening variable in associations between adverse parenting and internalizing and externalizing problems, but sleep problems did not. This indirect association was moderated by gender, such that the association between adverse parenting and daytime sleepiness only emerged as significant for girls.

Conclusions

These findings suggest that daytime‐related sleep behaviors may serve as a mechanism through which harsh or neglectful parenting is related to internalizing and externalizing psychopathology in adolescence, particularly for adolescent girls.
A Concise History of the Caribbean
Authors: Higman B. W.
Published: June 2021

A Concise History of the Caribbean offers a comprehensive interpretation of the history of the Caribbean islands from the beginning of human settlement to the present. It narrates processes of early human migration, the disastrous consequences of European colonisation, the development of slavery and the slave trade, the extraordinary profits earned by the plantation economy, the great revolution in Haiti, movements towards political independence, the Cuban Revolution, and the diaspora of Caribbean people. In this second edition, Higman covers the political, social, and environmental developments of the last decade, offering sections on insular politics, Cuban communism, earthquakes, hurricanes, climate change, resource ecologies, epidemics, identity and reparations. Written in a lively and accessible style, and current with the most recent research, the book provides a compelling narrative of Caribbean history essential for students and visitors.
Power and Emotion in Ancient Judaism
Authors: Mermelstein Ari
Published: June 2021

In this book, Ari Mermelstein examines the mutually-reinforcing relationship between power and emotion in ancient Judaism. Ancient Jewish writers in both Palestine and the diaspora contended that Jewish identity entails not simply allegiance to God and performance of the commandments but also the acquisition of specific emotional norms. These rules regarding feeling were both shaped by and responses to networks of power - God, the foreign empire, and other groups of Jews - which threatened Jews' sense of agency. According to these writers, emotional communities that felt Jewish would succeed in neutralizing the power wielded over them by others and, depending on the circumstances, restore their power to acculturate, maintain their Jewish identity, and achieve redemption. An important contribution to the history of emotions, this book argues that power relations are the basis for historical changes in emotion discourse.
Musicians of Bath and Beyond: Edward Loder (1809-1865) and his Family
Authors: Cooper Liz , Chandler David , Clarke Andrew , Szuster Julja , Banfield Stephen , Ellsworth Therese , Golby David J. , Langfield Valerie , Lamb Andrew , Mero Alison , Rodmell Paul , Spring Matthew
Published: June 2021

Musicians of Bath and Beyond: Edward Loder (1809-1865) and his Family illuminates three areas that have recently attracted much interest: the musical profession, music in the British provincesand colonies, and English Romantic opera. The Loder family was pre-eminent in Bath's musical world in the early nineteenth century. John David Loder (1788-1846) led the theatre orchestra there from1807, and later the Philharmonic orchestra and Ancient Concerts in London; he also wrote the leading instruction manual on violin playing and taught violin at the Royal Academy of Music. His son Edward James (1809-65) was a brilliant but underrated composer of opera, songs, and piano music. George Loder (1816-68) was a well-known flautist and conductor who made a name in New York and eventuallysettled in Adelaide, where he conducted the Australian premieres of Les Huguenots, Faust, and other important operas. Kate Fanny Loder (1825-1904) became a successful pianist and teacher in early Victorian London, and she is only now getting her due as a composer. This book takes advantage of new and often surprising biographical research on the Loder family as a whole and its four main figures. It uses them to illustrate several aspects of music history: the position of professional musicians in Victorian society; music in the provinces, especially Bath and Manchester;the Victorian opera libretto; orchestra direction; violin teaching; travelling musicians in the US and Australasia; opera singers and companies; and media responses to English opera. The concludingsection is an intense analysis and reassessment of Edward Loder's music, with special emphasis on his greatest work, the opera Raymond and Agnes. NICHOLAS TEMPERLEY is Professor Emeritus of Musicology at the University of Illinois at Urbana-Champaign and is a leading authority on Victorian music. CONTRIBUTORS: Stephen Banfield, David Chandler, Andrew Clarke, Liz Cooper,Therese Ellsworth, David J. Golby, Andrew Lamb, Valerie Langfield, Alison Mero, Paul Rodmell, Matthew Spring, Julja Szuster, Nicholas Temperley
A Governmentality of Online Gambling: Quebec’s Contested Internet Gambling Website Blocking Provisions
Authors: French Martin , Tardif Dani , Kairouz Sylvia , Savard Annie-Claude
Published: June 2021

This article examines Canada’s first internet gambling website blocking scheme, which was enacted in Quebec as part of the implementation of the province’s 2015 budget. Using qualitative research methods, the article illustrates the complexities of regulating online gambling. Influenced by critical sociological and anthropological studies of gambling, and taking a socio-legal, governmentality perspective, it shows how socio-legal studies can illuminate research on the regulation of gambling, and how the study of online gambling can, as a sentinel site for the regulation of online consumption, contribute to the development of socio-legal studies. Our analysis shows that the governmentality of online gambling is framed so as to exclude 1) a range of risks (e.g., related to consumer profiling and the capacity to stimulate “addictive consumption”), 2) the heterogeneity of everyday experience that connects online gambling with online addictive consumption more generally, and 3) a range of possibilities for governing online gambling otherwise.
The process for individuating TRIZ Inventive Principles: deterministic, stochastic or domain-oriented?
Authors: Borgianni Yuri , Fiorineschi Lorenzo , Frillici Francesco Saverio , Rotini Federico
Published: June 2021

Although TRIZ is widely acknowledged as a powerful aid to improve efficacy and efficiency of the creative design process, practitioners diffusedly experience difficulties in the selection of the most suitable tool. Such an issue represents a severe limitation in consideration of the large number of tools TRIZ offers. Here, Inventive Principles (IPs) are acknowledged as the most popular TRIZ technique, and their conjointly use with the Contradiction Matrix makes the selection of the appropriate IP a sufficiently supported task. However, the reliability of the Contradiction Matrix is often questioned and an agreement on a solid and reliable procedure for the selection of IPs is far from being reached. In such a context, the paper investigates the recurrence of IPs to solve contradictions, with reference to a classification framework that takes into consideration the nature of the problem to be solved and the technical-scientific domain it belongs to. The outcomes of the analysis reveal that leveraged IPs are considerably related with the technical-scientific domain and the nature of the problem to be solved. The found relationships are worth delving into and translating into selection guidelines.
Homology andK-theory of dynamical systems I. Torsion-free ample groupoids
Authors: PROIETTI VALERIO , YAMASHITA MAKOTO
Published: June 2021

Given an ample groupoid, we construct a spectral sequence with groupoid homology with integer coefficients on the second sheet, converging to theK-groups of the (reduced) groupoid C$^*$-algebra, provided the groupoid has torsion-free stabilizers and satisfies a strong form of the Baum–Connes conjecture. The construction is based on the triangulated category approach to the Baum–Connes conjecture developed by Meyer and Nest. We also present a few applications to topological dynamics and discuss the HK conjecture of Matui.
Influence of microbiological culture results on antibiotic choices for veterans with hospital-acquired pneumonia and ventilator-associated pneumonia
Authors: Bej Taissa A. , Christian Robbie L. , Sims Sharanie V. , Wilson Brigid M. , Song Sunah , Akpoji Ukwen C. , Bonomo Robert A. , Perez Federico , Jump Robin L. P.
Published: June 2021

Objective:

We examined the impact of microbiological results from respiratory samples on choice of antibiotic therapy in patients treated for hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP).

Design:

Four-year retrospective study.

Setting:

Veterans’ Health Administration (VHA).

Patients:

VHA patients hospitalized with HAP or VAP and with respiratory cultures between October 1, 2014, and September 30, 2018.

Interventions:

We compared patients with positive and negative respiratory culture results, assessing changes in antibiotic class and Antibiotic Spectrum Index (ASI) from the day of sample collection (day 0) through day 7.

Results:

Between October 1, 2014, and September 30, 2018, we identified 5,086 patients with HAP/VAP: 2,952 with positive culture results and 2,134 with negative culture results. All-cause 30-day mortality was 21% for both groups. The mean time from respiratory sample receipt in the laboratory to final respiratory culture result was longer for those with positive (2.9 ± 1.3 days) compared to negative results (2.5 ± 1.3 days; P < .001). The most common pathogens were Staphylococcus aureus and Pseudomonas aeruginosa. Vancomycin and β-lactam/β-lactamase inhibitors were the most commonly prescribed agents. The decrease in the median ASI from 13 to 8 between days 0 and 6 was similar among patients with positive and negative respiratory cultures. Patients with negative cultures were more likely to be off antibiotics from day 3 onward.

Conclusions:

The results of respiratory cultures had only a small influence on antibiotics used during the treatment of HAP/VAP. The decrease in ASI for both groups suggests the integration of antibiotic stewardship principles, including de-escalation, into the care of patients with HAP/VAP.
In pursuit of the holy grail: Improving C. difficile testing appropriateness with iterative electronic health record clinical decision support and targeted test restriction
Authors: Karlovich Norah S. , Sata Suchita Shah , Griffith Brian , Coop Ashley , Kalu Ibukunoluwa C. , Engemann John J. , Seidelman Jessica , Turner Nicholas A. , Polage Christopher R. , Smith Becky A. , Lewis Sarah S.
Published: June 2021

Objective:

To determine the impact of electronic health record (EHR)–based interventions and test restriction on Clostridioides difficile tests (CDTs) and hospital-onset C. difficile infection (HO-CDI).

Design:

Quasi-experimental study in 3 hospitals.

Setting:

957-bed academic (hospital A), 354-bed (hospital B), and 175-bed (hospital C) academic-affiliated community hospitals.

Interventions:

Three EHR-based interventions were sequentially implemented: (1) alert when ordering a CDT if laxatives administered within 24 hours (January 2018); (2) cancellation of CDT orders after 24 hours (October 2018); (3) contextual rule-driven order questions requiring justification when laxative administered or lack of EHR documentation of diarrhea (July 2019). In February 2019, hospital C implemented a gatekeeper intervention requiring approval for all CDTs after hospital day 3. The impact of the interventions on C. difficile testing and HO-CDI rates was estimated using an interrupted time-series analysis.

Results:

C. difficile testing was already declining in the preintervention period (annual change in incidence rate [IR], 0.79; 95% CI, 0.72–0.87) and did not decrease further with the EHR interventions. The laxative alert was temporally associated with a trend reduction in HO-CDI (annual change in IR from baseline, 0.85; 95% CI, 0.75–0.96) at hospitals A and B. The gatekeeper intervention at hospital C was associated with level (IRR, 0.50; 95% CI, 0.42-0.60) and trend reductions in C. difficile testing (annual change in IR, 0.91; 95% CI, 0.85–0.98) and level (IRR 0.42; 95% CI, 0.22–0.81) and trend reductions in HO-CDI (annual change in IR, 0.68; 95% CI, 0.50–0.92) relative to the baseline period.

Conclusions:

Test restriction was more effective than EHR-based clinical decision support to reduce C. difficile testing in our 3-hospital system.
The burden of excessive saturated fatty acid intake attributed to ultra-processed food consumption: a study conducted with nationally representative cross-sectional studies from eight countries
Authors: Steele Eurídice Martínez , Batis Carolina , Cediel Gustavo , Louzada Maria Laura da Costa , Khandpur Neha , Machado Priscila , Moubarac Jean-Claude , Rauber Fernanda , Jedlicki Marcela Reyes , Levy Renata Bertazzi , Monteiro Carlos A.
Published: June 2021

Cross-sectional nutritional survey data collected in eight countries were used to estimate saturated fatty acid intakes. Our objective was to estimate the proportion of excessive saturated fatty acid intakes (>10 % of total energy intake) that could be avoided if ultra-processed food consumption was reduced to levels observed in the first quintile of each country. Secondary analysis was performed of 24 h dietary recall or food diary/record data collected by the most recently available nationally representative cross-sectional surveys carried out in Brazil (2008–9), Chile (2010), Colombia (2005), Mexico (2012), Australia (2011–12), the UK (2008–16), Canada (2015) and the US (2015–16). Population attributable fractions estimated the impact of reducing ultra-processed food consumption on excessive saturated fatty acid intakes (above 10 % of total energy intake) in each country. Significant relative reductions in the percentage of excessive saturated fatty acid intakes would be observed in all countries if ultra-processed food consumption was reduced to levels observed in the first quintile's consumption. The reductions in excessive intakes ranged from 10⋅0 % (95 % CI 6⋅2–13⋅6 %) in Canada to 35⋅0 % (95 % CI 28⋅7–48⋅0 %) in Mexico. In all eight studied countries, all presenting more than 30 % of intakes with excessive saturated fatty acids, lowering the dietary contribution of ultra-processed foods to attainable, context-specific levels was shown to be a potentially effective way to reduce the percentage of intakes with excessive saturated fatty acids, which may play an important role in the prevention of non-communicable diseases, particularly cardiovascular diseases.
Chaos and frequent hypercyclicity for composition operators
Authors: Darji Udayan B. , Pires Benito
Published: June 2021

The notions of chaos and frequent hypercyclicity enjoy an intimate relationship in linear dynamics. Indeed, after a series of partial results, it was shown by Bayart and Ruzsa in 2015 that for backward weighted shifts on $\ell _p(\mathbb {Z})$, the notions of chaos and frequent hypercyclicity coincide. It is with some effort that one shows that these two notions are distinct. Bayart and Grivaux in 2007 constructed a non-chaotic frequently hypercyclic weighted shift on $c_0$. It was only in 2017 that Menet settled negatively whether every chaotic operator is frequently hypercylic. In this article, we show that for a large class of composition operators on $L^{p}$-spaces, the notions of chaos and frequent hypercyclicity coincide. Moreover, in this particular class, an invertible operator is frequently hypercyclic if and only if its inverse is frequently hypercyclic. This is in contrast to a very recent result of Menet where an invertible operator frequently hypercyclic on $\ell _1$ whose inverse is not frequently hypercyclic is constructed.
A lead through approach for programming a welding arm robot using machine vision
Authors: Ali Mohamed Hosni Mohamed , Atia Mostafa Rostom
Published: June 2021

Welding is a complex manufacturing process. Its quality depends on the welder skills, especially in welding complex paths. For consistency in modern industries, the arm robot is used to accomplish this task. However, its programming and reprogramming are time consuming and costly and need an expert programmer. These limit the use of robots in medium and small industries. This paper introduces a new supervised learning technique for programming a 4-degree of freedom (DOF) welding arm robot with an automatic feeding electrode. This technique is based on grasping the welding path control points and motion behavior of an expert welder. This is achieved by letting the welder move the robot end effector, which represents the welding torch, through the welding path. At the path control points, the position and speed are recorded using a vision system. Later, these data are retrieved by the robot to replicate the welding path. Several 2D paths are tested to assess the proposed approach accuracy and programming time and easiness in comparison with the common one. The results prove that the proposed approach includes fewer steps and consumes less programming time. Moreover, programming can be accomplished by the welder and no need for an expert programmer. These enhancements will improve the share of robots in welding and similar industries.
Assist system for remote manipulation of electric drills by the robot “WAREC-1R” using deep reinforcement learning
Authors: Sun Xiao , Naito Hiroshi , Namiki Akio , Liu Yang , Matsuzawa Takashi , Takanishi Atsuo
Published: June 2021

Operation of tools has long been studied in robotics. Although appropriate hold of the tool by robots is the base of successful tool operation, it is not with ease especially for tools with complicated shape. In this paper, an assist system for a four-limbed robot is proposed for remote operation of reaching and grasping electric drills using deep reinforcement learning. Through comparative evaluation experiments, the increase of success rate for reaching and grasping is verified and the decrease in both physical and mental workload of the operator is also validated by the index of NASA-TLX.