bluuebunny/crossref_metadata_2025 huggingface dataset:
Early and Long-Term Outcomes of Patients Undergoing Surgery for Native and Prosthetic Valve Endocarditis: The Role of Preoperative Neutrophil-to-Lymphocyte Ratio, Neutrophil-to-Platelet Ratio, and Monocyte-to Lymphocyte Ratio
Authors: Galeone Antonella , Gardellini Jacopo , Di Nicola Venanzio , Perrone Fabiola , Menzione Maria Serena , Di Gaetano Renato , Luciani Giovanni Battista
Published: January 2025

Background/Objectives: Previous studies evaluated the prognostic role of hematological parameters in predicting outcome in patients with infective endocarditis (IE). However, only a few studies evaluated the role of hematological parameters in patients undergoing surgery for IE. The aim of this study was to review our 20-year experience with the treatment of native (NVE) and prosthetic (PVE) valve endocarditis and to evaluate the role of neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-platelet ratio (NPR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to monocyte ratio (NMR), and systemic inflammatory index (SII) on early and long-term outcomes of patients undergoing surgery for NVE and PVE. Methods: All adult patients undergoing surgery for NVE and PVE at our institution between January 2001 and December 2022 were included in the study. Preoperative NLR, NPR, PLR, MLR, NMR, and SII were calculated using hemograms with complete blood count. Results: During the study period, 503 patients, 371 (74%) males, median age 65 (52–73) years, underwent surgery for NVE (n = 337, 67%) or PVE (n = 166, 33%). Patients with PVE had significantly more aortic annulus abscess (95 (57%) vs. 51 (15%); p < 0.001), longer CPB (180 (131–235) vs. 105 (84–145) min; p < 0.001) and aortic cross-clamping times (129 (96–175) vs. 82 (64–114) min; p < 0.001), and received more aortic homografts (47 (28%) vs. 28 (9%); p < 0.001) and postoperative pacemaker implantation (25 (15%) vs. 20 (6%); p < 0.001 compared to patients with NVE. Preoperative NLR was 3.7 (2.4–6.1), NPR was 23 (16–37), PLR was 159 (106–210), NMR was 8.4 (6.6–12), MRL was 0.41 (0.29–0.62], and SII was 790 (485–1396). NLR, NPR, and MLR were significantly lower in patients with NVE compared to patients with PVE and in survivors compared to non-survivors. Overall mean survival time was 12.2 ± 0.5 years, with patients with NVE having better early and late survival compared to patients with PVE. Patients with preoperative NLR < 3.8, NPR < 30.9, and MLR < 0.4 had significantly better mean survival time compared to patients with preoperative NLR > 3.8, NPR > 30.9, and MLR > 0.4, respectively. Conclusions: In patients undergoing surgery for IE, preoperative higher NLR, NPR, and MLR are associated with increased early and long-term mortality.
Effectiveness of Ocrelizumab on Disease Progression and Disability Status in Multiple Sclerosis Patients: A Two-Year Prospective Cohort Study
Authors: Schuldesz Amanda Claudia , Tudor Raluca , Cornea Amalia , Geni Dorina Nicola , Lata Irina Nicoleta , Simu Mihaela
Published: January 2025

Background and Objectives: Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation and neurodegeneration. Ocrelizumab, a humanized anti-CD20 monoclonal antibody, has shown promise in reducing disease activity in MS patients. This prospective study aims to assess the effectiveness of ocrelizumab in reducing confirmed disability progression in patients with relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) over a two-year period. By evaluating clinical data, and MRI findings, this study seeks to provide comprehensive insights into ocrelizumab’s impact on disease dynamics and disability. Materials and Methods: Ninety-eight patients aged 18 to 65 with confirmed MS were enrolled under ocrelizumab therapy at the Neurology Department of “Pius Brinzeu” Clinical Emergency Hospital in Romania between July 2020 and July 2024. Participants were assessed at baseline and every six months over two years. The key outcomes measured were changes in the Expanded Disability Status Scale (EDSS) as a measure of confirmed disability progression (CDP), annualized relapse rate (ARR), and MRI findings. Results: Over the two-year period, the mean EDSS score significantly decreased from 5.2 ± 1.8 to 4.6 ± 1.7 (mean change = −0.6 ± 0.9; p = 0.032), indicating improved neurological function. The proportion of patients experiencing relapses dropped markedly from 61.2% to 14.3% (p < 0.001). The MRI results showed significant reductions in patients with new or enlarging T2 lesions from 68.4% to 27.6% (p < 0.001) and gadolinium-enhancing lesions from 44.9% to 15.3% (p < 0.001). Patients previously treated with natalizumab exhibited a greater reduction in EDSS scores (−1.0 ± 0.8; p = 0.001) compared to other treatments. Multivariate regression identified the baseline EDSS score (β = 0.65; p < 0.001), previous natalizumab use (β = −0.30; p = 0.013), and age at diagnosis (β = 0.02; p = 0.048) as significant predictors of two-year EDSS scores. While markers of active inflammation decreased, the proportion of patients with brain atrophy increased from 31.6% to 43.9% (not statistically significant; p = 0.105). SPMS patients had higher rates of brain atrophy at baseline (61.1% vs. 25.0%; p = 0.007) and at two years (100.0% vs. 31.3%; p < 0.001) compared to RRMS patients. Conclusions: Ocrelizumab effectively reduced disease activity and improved neurological disability over two years in both RRMS and SPMS patients. Significant reductions in relapse rates and MRI markers of inflammation were observed. Previous natalizumab treatment was associated with greater improvements. Despite these benefits, the progression of neurodegeneration, particularly brain atrophy in SPMS patients, underscores the need for additional strategies targeting neurodegenerative aspects of MS.
Supermicrosurgical Vascular Anastomosis—A Comparative Study of Lumen-Enhancing Visibility Techniques
Authors: Ratoiu Vladut-Alin , Cretu Andrei , Hodea Florin-Vlad , Dumitru Catalina-Stefania , Grosu-Bularda Andreea , Bordeanu-Diaconescu Eliza-Maria , Teodoreanu Razvan-Nicolae , Lascar Ioan , Hariga Cristian-Sorin
Published: January 2025

Background: The development of microsurgical techniques has enabled reconstructive versatility in various clinical scenarios. Supermicrosurgery is an advanced microsurgical technique ensuring precise reconstructions by operating on small-caliber vessels and nerves, with applications in reconstructive surgeries. Objectives: This study aims to compare the effectiveness of four low-cost training models, thereby improving surgical precision and reducing the learning curve for novice surgeons. Materials and Methods: We conducted a prospective non-randomized study comparing the classic anastomosis technique, the intravascular stenting (IVaS) technique, the color contrast (CC) technique, and our newly introduced double-contrast (DC) technique, which combines IVaS with CC. We used a non-living experimental model represented by chicken wings, analyzing the vessel preparation and anastomosis time, anastomosis patency, and back wall biting through a standardized protocol. We performed 120 end-to-end anastomoses in total, with vessel diameters ranging from 0.5 to 0.8 mm. Results: CC demonstrated superior time efficiency and success rates, reaffirming it as a reliable option in supermicrosurgery, while DC showed slightly better time efficiency and patency compared to both IVaS alone and the classic method. CC outperformed the others in anastomosis time, patency, and back wall catching, reaffirming its reliability in supermicrosurgery. Conclusions: Although DC did not significantly improve patency, it reduced back wall engagement. This makes the DC technique beneficial for trainees working on vessels under 0.5 mm in diameter, where stenting is often required, improving surgical precision and reducing the learning curve, leading to better outcomes in supermicrosurgery.
Identification of Key Predictors of Cryoglobulinemia Severity at Diagnosis: Threshold, Type, and Severity Score at Diagnosis
Authors: Razanamahery Jerome , Aubertin Nils , Bach Bunner Maxime , Blaison Gilles , Bouldoires Bastien , Soumagne Thibaud
Published: January 2025

Background: Cryoglobulinemia (CG) syndrome is a heterogeneous condition characterized by the presence of cryoglobulins in serum, often leading to vasculitis with protean clinical manifestations. Understanding the presentation of cryoglobulinemia-related symptoms based on cryoprecipitate levels, GC type, and severity at diagnosis is essential for effective management. Hence, this study aimed to provide a comprehensive analysis of patients with positive cryoglobulin detection to investigate these aspects. Methods: We conducted a retrospective review of clinical charts from patients with positive cryoglobulin detection at Colmar Hospital between May 2015 and April 2019. Results: Among 166 patients with positive cryoglobulins, the median cryoprecipitate value was 37 mg/L [IQR: 25–70], with 62% of patients below the 50 mg/L threshold. High cryoprecipitate levels were associated with C-virus hepatitis (p = 0.0007), increased fatigue (p = 0.001), fever (p = 0.0013), weight loss (p = 0.028), and musculoskeletal symptoms (p = 0.002). These patients also exhibited decreases in complement fractions (p-values 0.017 to 0.006). At the end of the one-year follow-up, they required frequent renal replacement therapy (p < 0.0001) and had a higher mortality rate (p = 0.02). Based on the CG type, patients with type I GC had splenomegaly (p = 0.039) and hemopathy (p = 0.001). According to severity at initial presentation, the severe patients had more purpura (p < 0.001), Raynaud’s phenomenon (p = 0.039), and leukocytoclastic vasculitis on skin biopsy (p < 0.001), along with higher cryoprecipitate levels (p = 0.011). Multivariate analysis identified purpura (OR: 10.25), hematological malignancy (OR: 7.06), Raynaud’s phenomenon (OR: 6.41), and cryoprecipitate levels (OR: 1.02) as significant markers of disease severity serving for the development of a severity score for clinical practice. Conclusions: This study identifies severity markers in patients with positive cryoprecipitate and proposes a score related to severity at diagnosis.
The Clinical Use of Myo-Inositol in IVF-ET: A Position Statement from the Experts Group on Inositol in Basic and Clinical Research and on PCOS (EGOI-PCOS), the Polish Society of Andrology, and the International Scientific Association for the Support and Development of Medical Technologies
Authors: Wdowiak Artur , Bakalczuk Szymon , Filip Michał , Laganà Antonio Simone , Unfer Vittorio
Published: January 2025

Background: Myo-inositol plays a vital role in human health, functioning as a second messenger of FSH and facilitating the transport of glucose into the cell. Consequently, myo-inositol is regularly utilized in the treatment of polycystic ovary syndrome (PCOS), wherein it acts upon metabolic factors, improving insulin sensitivity and reducing total androgen levels. Patients with PCOS frequently suffer from infertility; thus, the use of myo-inositol has been explored in improving assistive reproductive technique (ART) procedures. This is by no means limited to patients with PCOS, as inositol has found applications in non-PCOS patient groups in addition to in male factor infertility. This joint statement from the Experts Group on Inositol in Basic and Clinical Research and on PCOS (EGOI-PCOS), the Polish Society of Andrology, and the International Scientific Association for the Support and Development of Medical Technologies discusses the latest evidence on this topic, with the aim of interrogating whether myo-inositol could be implemented in everyday ART patient care. Methods: The authors conducted a narrative review performed via an independent literature search between July and August 2024, using the search platforms PubMed, Web of Science, and Google Scholar. Results: In both non-PCOS and PCOS populations seeking IVF care, MI supplementation prior to ovarian stimulation may positively affect gonadotropin use and duration, oocyte and embryo quality, fertilization, and clinical pregnancy rates. Conclusions: This position statement recommends that myo-inositol be considered as a potential pretreatment strategy prior to ovarian hyperstimulation with gonadotropins.
Joint Optimization of Berths and Quay Cranes Considering Carbon Emissions: A Case Study of a Container Terminal in China
Authors: Lu Houjun , Lu Xiao
Published: January 2025

The International Maritime Organization (IMO) aims for net zero emissions in shipping by 2050. Ports, key links in the supply chain, are embracing green innovation, focusing on efficient berth and quay crane scheduling to support green port development amid limited resources. Additionally, the energy consumption and carbon emissions from the port shipping industry contribute significantly to environmental challenges and the sustainable development of ports. Therefore, reducing carbon emissions, particularly those generated during vessel berthing, has become a pressing task for the industry. The increasing complexity of berth allocation now requires compliance to vessel service standards while controlling carbon emissions. This study presents an integrated model that incorporates tidal factors into the joint optimization of berth and quay crane operations, addressing both service standards and emissions during port stays and crane activities, and further designs a PSO-GA hybrid algorithm, combining particle swarm optimization (PSO) with crossover and mutation operators from a genetic algorithm (GA), to enhance optimization accuracy and efficiency. Numerical experiments using actual data from a container terminal demonstrate the effectiveness and superiority of the PSO-GA algorithm compared to the traditional GA and PSO. The results show a reduction in total operational costs by 24.1% and carbon emissions by 15.3%, highlighting significant potential savings and environmental benefits for port operators. Furthermore, the findings reveal the critical role of tidal factors in improving berth and quay crane scheduling. The results provide decision-making support for the efficient operation and carbon emission control of green ports.
Evaluating the Accuracy of the ERA5 Model in Predicting Wind Speeds Across Coastal and Offshore Regions
Authors: Alkhalidi Mohamad , Al-Dabbous Abdullah , Al-Dabbous Shoug , Alzaid Dalal
Published: January 2025

Accurate wind speed and direction data are vital for coastal engineering, renewable energy, and climate resilience, particularly in regions with sparse observational datasets. This study evaluates the ERA5 reanalysis model’s performance in predicting wind speeds and directions at ten coastal and offshore stations in Kuwait from 2010 to 2017. This analysis reveals that ERA5 effectively captures general wind speed patterns, with offshore stations demonstrating stronger correlations (up to 0.85) and higher Perkins Skill Score (PSS) values (up to 0.94). However, the model consistently underestimates wind variability and extreme wind events, especially at coastal stations, where correlation coefficients dropped to 0.35. Wind direction analysis highlighted ERA5’s ability to replicate dominant northwest wind patterns. However, it reveals notable biases and underrepresented variability during transitional seasons. Taylor diagrams and error metrics further emphasize ERA5’s challenges in capturing localized dynamics influenced by land-sea interactions. Enhancements such as localized calibration using high-resolution datasets, hybrid models incorporating machine learning techniques, and long-term monitoring networks are recommended to improve accuracy. By addressing these limitations, ERA5 can more effectively support engineering applications, including coastal infrastructure design and renewable energy development, while advancing Kuwait’s sustainable development goals. This study provides valuable insights into refining reanalysis model performance in complex coastal environments.
Human Fungal Infections: Diagnostic and Therapeutic Challenges
Authors: Vyzantiadis Timoleon-Achilleas , Gavriilaki Eleni , Tragiannidis Athanasios
Published: January 2025

Fungal infections, either invasive and disseminated or cutaneous and superficial, are an important and increasing cause of morbidity [...]
Novel 2-Thiazolylhydrazone with Druggable Properties for Antifungal Application
Authors: de Morais Wallace Cordeiro , Costa Gustavo Henrique Oliveira , Pitcella Vinícius Leal , Protti João Victor Vanolli , Moreira Carolina Paula de Souza , Gonçalves José Eduardo , Johann Susana , de Oliveira Renata Barbosa
Published: January 2025

Fungal infections have become a growing concern in healthcare, particularly in immunocompromised individuals, with species like Candida, Cryptococcus, and Sporothrix posing significant challenges due to rising resistance and limited treatment options. In response, novel antifungal agents are being explored, including thiazolyl hydrazones. This study focuses on the development of a novel thiazolylhydrazone derivative, RW3. RW3 was synthesized to improve its water solubility and pharmacokinetic properties. The compound demonstrated a broad antifungal spectrum, particularly effective against Cryptococcus neoformans and Candida auris, with minimal irritant potential and low cytotoxicity. RW3 showed favorable solubility and high intestinal permeability, indicating potential for oral administration. The results suggest RW3 as a promising lead for further development as a therapeutic agent for systemic fungal infections. These findings underscore the importance of optimizing drug properties to enhance efficacy and safety profiles, opening the path for the development of innovative antifungal treatments.
Remote-Customized Telecontrol for Patients with Rheumatoid Arthritis: The iARPlus (Innovative Approach in Rheumatology) Initiative
Authors: Salaffi Fausto , Farah Sonia , Di Donato Eleonora , Sonnati Massimo , Filippucci Emilio , De Angelis Rossella , Gabbrielli Francesco , Di Carlo Marco
Published: January 2025

Objective. Telecontrol approaches for rheumatoid arthritis (RA) management aim to enhance patient outcomes. This pilot study assessed whether the Rheumatoid Arthritis Impact of Disease (RAID) approach could be used during teleconsultations to monitor RA disease activity through a web-based platform called iARPlus (Innovative Approach in Rheumatology). Methods. Forty RA patients participated in two in-person visits (baseline and 12 months) and seven teleconsultations over 12 months, collected via the iARPlus portal and accessible through an internet browser. Disease activity, at baseline and follow-up, was measured using the Clinical Disease Activity Index (CDAI) and self-reported RAID scores throughout the study. The RAID approach, developed by the European Alliance of Associations for Rheumatology (EULAR), combines key patient-reported outcomes (PROs). Results. Nineteen patients (mean age: 49.3 years) were treated with Janus kinase inhibitors (JAKis), and 21 patients (mean age: 48.1 years) received adalimumab. All patients had active disease (mean CDAI 27.9 ± 4.8). Strong correlations were found between CDAI and RAID scores at baseline (ρ = 0.809, p < 0.0001) and at follow-up (ρ = 0.789, p < 0.0001). JAKi-treated patients showed greater reductions in RAID scores, pain relief, and higher rates of disease remission compared to adalimumab-treated patients. Conclusions. RAID scores were effective in teleconsultations for assessing RA disease activity. JAKi treatment resulted in better pain control and disease activity improvement compared to adalimumab. Further studies are needed to confirm the clinical and economic benefits of telecontrol for RA management.
Renal Dysfunction in Primary Aldosteronism: How, When, and Who?
Authors: Kitlinski Michael , Dreja Karl , Heleniak Zbigniew , Dębska-Ślizień Alicja
Published: January 2025

Primary aldosteronism (PA) is a major cause of hypertension, especially in younger patients. Early diagnosis and treatment are crucial to prevent damage to vital organs, including the heart and kidneys. Independent of blood pressure, aldosterone excess has direct deleterious effects on the kidneys, leading to tubulointerstitial fibrosis, glomerular hypertrophy, and glomerulosclerosis. Emerging biomarkers such as albuminuria and liver fatty acid-binding protein may have the potential to detect renal injury in PA, particularly in the setting of glomerular hyperfiltration. Comprehensive risk assessment of long-term renal dysfunction, based on both modifiable and non-modifiable risk factors, would aid clinicians in prediction and would even, in some cases, allow them to mitigate the risk of patients developing CKD in the setting of PA.
Cultural Heritages Lead to Less Dense and Greener Cities—Evidence from 371 Chinese Cities
Authors: Zhang Zhiyuan , Cheng Ruozhen , Dan Yangpeng , Wang Luyao
Published: January 2025

Cultural heritage sites play a significant role in shaping urban development, yet their impact on key urban outcomes remains underexplored. This study investigates how the number and proximity of heritage sites influence development through an analysis across 371 Chinese cities. Using a range of urban metrics, including population density, building height, urban form complexity, and green space accessibility, we find that cities with more heritage sites tend to exhibit lower population density (−0.168) and building height (−0.0314), respectively. These cities also show more complex urban forms and irregular city layouts, potentially caused by heritage preservations. We also analyze the impact of heritage sites on green accessibility, revealing that cities with more heritage sites have a higher green area per capita and better access to green spaces. Furthermore, our analysis of urban growth from 2000 to 2020 highlights the positive relationship between heritage sites and population growth (0.223), as well as the potential trade-offs between heritage preservation and GDPPC growth (−0.865). Our findings underscore the positive impacts of cultural heritage on urban development as well as address its potential trade-offs, highlighting the need for urban planning strategies that balance heritage preservation with sustainable growth and equitable access to green spaces.
The Application of Numerical Simulation in Debris Flow Disaster Early Warning: A Case Study of Shiyang Gully, China
Authors: Zheng Hao , Guo Lanlan , Liu Jifu , Chen Bin , Liu Lianyou
Published: January 2025

This study explores the application of numerical simulation in debris flow disaster early warning, using the Shiyang Gully in China as a case study. Using both the HEC-HMS and FLO-2D, the 18 June 2017 debris flow event was reconstructed to analyze the impacts of cumulative rainfall, rainfall intensity, and rainfall range on debris flow hazards. Simulation results showed that cumulative rainfall exceeding 90 mm or rainfall intensity surpassing 200 mm/8 h significantly increases debris flow depth, impact force, and affected areas, leading to severe structural damage. Expanding the rainfall range to the entire basin further amplifies disaster risks, increasing both inundation depth and exposed elements. Based on these findings, a four-tier debris flow early warning system was developed: (1) blue (IV) warning for cumulative rainfall of up to and including 20 mm or intensity of 200 mm/24 h, indicating preparation and monitoring; (2) yellow (III) warning for rainfall exceeding 20 mm but below 60 mm, requiring enhanced inspections and safety measures; (3) orange (II) warning for rainfall between 60 and 90 mm or intensity of 200 mm/12 h, necessitating immediate evacuation preparations; and (4) red (I) warning for rainfall over 90 mm or intensity of 200 mm/8 h, demanding full evacuation and emergency responses. This study demonstrates the value of numerical simulation in refining early warning systems by integrating multi-scenario analyses of rainfall parameters. The proposed system offers scientific and practical insights for enhancing debris flow disaster management, particularly in small, high-risk watersheds, providing a framework for cross-regional disaster mitigation strategies.
Gender Differences Are a Leading Factor in 5-Year Survival of Patients with Idiopathic Pulmonary Fibrosis over Antifibrotic Therapy Reduction
Authors: Tondo Pasquale , Scioscia Giulia , De Pace Cosimo C. , Murgolo Fabiola , Maci Federica , Stella Giulia M. , Pescatore Dalila , Foschino Barbaro Maria Pia , Lacedonia Donato
Published: January 2025

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with a median survival of 3–5 years. Antifibrotic therapies like pirfenidone and nintedanib slow progression, but the outcomes vary. Gender may influence disease presentation, progression, and response to treatment. This study evaluates the impact of gender on the 5-year survival, pharmacological management, and clinical outcomes of patients with IPF. Methods: A retrospective cohort study of 254 IPF patients was conducted, with 164 (131 males:33 females) having complete data. Patients underwent spirometry, DLCO, and 6 min walk tests. Data on comorbidities, smoking, antifibrotic therapy type, dosage adjustments, and adverse events were collected. We used Kaplan–Meier survival curves and logistic regression to assess gender-related differences in outcomes. Results: Men had worse lung function at diagnosis (FVC 74.9 ± 18.5 vs. 87.2 ± 20.1% of pred.; p < 0.001) and a higher smoking prevalence (74% vs. 30%; p < 0.001). Women had better survival (51.2 vs. 40.8 ± 19.2 months; p = 0.005) despite more frequent biopsy use (36% vs. 17%; p = 0.013). Women tolerated longer therapy better (p = 0.001). No differences were found between patients receiving reduced antifibrotic dosing and those receiving full dosing. Conclusions: Gender has a significant impact on IPF outcomes, with women demonstrating better survival and tolerance to long-term therapy. In contrast, reducing antifibrotic treatment does not appear to significantly affect survival outcomes. These findings underscore the need for future research on gender-specific management approaches.
Criteria for Assessing Exposure to Biomechanical Risk Factors: A Research-to-Practice Guide—Part 2: Upper Limbs
Authors: Graziosi Francesca , Bonfiglioli Roberta , Decataldo Francesco , Violante Francesco Saverio
Published: January 2025

Musculoskeletal disorders are the most prevalent occupational health problem and are often related to biomechanical risk factors. Over the last forty years, observational methods for exposure assessment have been proposed. To apply them effectively in the field, an in-depth knowledge of each methodology and a solid understanding of their actual predictive value and limitations are required. In this two-part guide, we discuss methods that have a solid scientific background, are based on expert consensus, and that do not require disproportionate technical, material, financial, and time resources. In Part 1, we focused on the Revised NIOSH Lifting Equation as a validated method for assessing manual material handling and discussed its application when dealing with task variability. In Part 2, we look at methods for the assessment of upper-limb biomechanical exposure in manual jobs. According to the above-mentioned criteria, we discuss methodologies proposed by the American Conference of Governmental Industrial Hygienists (ACGIH) and evaluate activities requiring high-speed continuous movement and the use of hand force, working with the arms above the shoulder level, to prevent localized fatigue in the upper extremities in cyclical work tasks. Finally, a preliminary proposal of a proportionate risk assessment of working duration in part-time jobs is presented.
Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management
Authors: Mi Tingwei , Sheng Chengwang , Lee Cassidy Kylene , Nguyen Peter , Zhang Yali V.
Published: January 2025

Chemosensation and mechanosensation are vital to insects’ survival and behavior, shaping critical physiological processes such as feeding, metabolism, mating, and reproduction. During feeding, insects rely on diverse chemosensory and mechanosensory receptors to distinguish between nutritious and harmful substances, enabling them to select suitable food sources while avoiding toxins. These receptors are distributed across various body parts, allowing insects to detect environmental cues about food quality and adjust their behaviors accordingly. A deeper understanding of insect sensory physiology, especially during feeding, not only enhances our knowledge of insect biology but also offers significant opportunities for practical applications. This review highlights recent advancements in research on feeding-related sensory receptors, covering a wide range of insect species, from the model organism Drosophila melanogaster to agricultural and human pests. Additionally, this review examines the potential of targeting insect sensory receptors for precision pest control. Disrupting behaviors such as feeding and reproduction emerges as a promising strategy for pest management. By interfering with these essential behaviors, we can effectively control pest populations while minimizing environmental impacts and promoting ecological balance.
Association Between Sociodemographic Variables, Healthy Habits, and Stress with Risk Scales for Liver Disease Associated with Metabolic Dysfunction
Authors: López-González Ángel Arturo , Martínez-Almoyna Rifá Emilio , Oliveira Hernán Paublini , Sánchez Cristina Martorell , Tárraga López Pedro Juan , Ramírez-Manent José Ignacio
Published: January 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common cause of chronic liver disease worldwide, with a multifactorial etiology. This study aims to evaluate the associations between various sociodemographic variables, healthy habits, and stress with risk scale values for MAFLD. Materials and Methods: A descriptive, cross-sectional study was conducted on 16,708 Spanish workers to assess how sociodemographic variables (age, gender, and socioeconomic status), healthy habits (smoking, Mediterranean diet adherence, and physical activity), and stress correlate with values from three MAFLD risk scales: fatty liver index (FLI), hepatic steatosis index (HSI), and lipid accumulation product (LAP). Results: All analyzed variables were associated with the values of the three MAFLD risk scales. Among them, the variables showing the strongest associations (represented by odds ratio values) were age and physical activity. Conclusions: The profile of an individual at higher risk of elevated MAFLD risk scale values is a male, aged 50 or older, belonging to lower socioeconomic levels (manual laborers), a smoker, sedentary, with low adherence to the Mediterranean diet, and with high stress scale scores.
Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model
Authors: Pyka Dariusz , Noszczyk-Nowak Agnieszka , Krawiec Karina , Świetlik Tomasz , Opieliński Krzysztof J.
Published: January 2025

The authors of this study focused their research on developing cap geometries for the FibroScan® elastograph (FibroScan, EchoSens, Paris, France) measuring head aimed at a non-invasive assessment of liver condition for transplantation using a pig animal model. Numerical models were created to simulate the propagation of a mechanical wave through a biological medium induced by the FibroScan® elastograph measuring head. The designed caps were intended to replicate the skin–muscle–rib–liver structures to minimize the risk of damage caused by mechanical wave excitation when directly applied to liver tissue. The construction process of numerical models for the liver and surrounding tissues is presented, along with simulations reflecting the mechanical and acoustic properties of the wave propagation process. The results obtained from in vivo measurements on pigs were validated through a numerical analysis, confirming a high level of agreement between the test results and the numerical model.
Optimization of Material Flow and Product Allocation in Inter-Unit Operations: A Case Study of a Refrigerator Manufacturing Facility
Authors: Karagoz Selman , Karagoz Yasin
Published: January 2025

Background: Logistics operations are integral to manufacturing systems, particularly in the transportation processes that occur not only between facilities and stakeholders but also between warehouses and workstations within a facility. The design of functional areas and allocating goods to appropriate zones within the warehouse management system (WMS) are critical activities that substantially influence the efficiency of manufacturing logistics operations. Methods: This study develops a mixed-integer programming (MIP) model to optimize material flow and product routing in manufacturing. The model identifies efficient pathways, assigns products to routes, and determines the required material-handling equipment. It is implemented in Python (3.11.5) using the Pyomo (6.7.3) package and the CBC solver (2.10.11), with sensitivity analysis performed on constraints and decision variables to evaluate robustness. Results: The findings indicate that Material Flow 3 and Material-Handling Equipment 1 represent the optimal configurations for managing the majority of goods within the manufacturing system. Conclusions: The proposed mathematical model supports the decision-making process by enabling adjustments to the proportions of functional areas within the manufacturing logistics system, ensuring operational efficiency and flexibility in response to changing demands. Furthermore, the study offers managerial insights and suggests directions for future research.
Development of Tailored Porous Ti6Al4V Materials by Extrusion 3D Printing
Authors: Olmos Luis , González-Pedraza Ana Silvia , Vergara-Hernández Héctor Javier , Bouvard Didier , López-Cornejo Monserrat Sofía , Servín-Castañeda Rumualdo
Published: January 2025

Nowadays, metallic bone replacement is in high demand due to different issues, like sicknesses and accidents. Thus, bone implants are fabricated with tailored properties and microstructure for long-term use in the human body. To improve such implants, 3D printing is the most promising technique. Therefore, this work aims to evaluate the fabrication of porous materials by extrusion 3D printing of Ti6Al4V. Cylindrical samples were fabricated from pellets for metal injection molding of Ti6Al4V powders, creating hexagonal channels with three different sizes. The densification kinetics was evaluated by dilatometry tests, which enabled following the densification of the samples during the sintering cycle. Subsequently, the samples were characterized by scanning electron microscopy and X-ray computed tomography to analyze their microstructure. Compression tests evaluated the mechanical strength of sintered samples. It was found that the hexagonal shape during printing is better defined as the channel size increases. The results show similar behavior for each of the channel sizes during sintering; however, greater densification is obtained as the channel size decreases. Additionally, microporosity is obtained at the particle level, which is completely interconnected, ensuring the passage of fluids through the entire sample. On the other hand, as the channel size increases, Young’s modulus and yield strength are considerably reduced. The main conclusion is that parts with two scales of porosity can be designed by the 3D printing extrusion process.
Eliminating Anisotropy of 7085 Alloy Forgings via Temperature Combination Control During Two-Stage Multi-Directional Forging
Authors: Yin Xiao , Liu Wensheng , Tan Xin , Wu Mingdong , Yuan Shuo , Xiao Daihong , Huang Lanping
Published: January 2025

Due to its high mechanical properties and low quench sensitivity, 7085 aluminum alloy is suitable for the aircraft industry. However, large cross-section forgings of 7085 alloy usually have over 40% anisotropy in mechanical behaviors, especially in the vertical direction. In this study, two-stage multi-directional forgings (MDFs) with different temperature combinations, isothermal medium-temperature composite MDF (MC-MDF) and isothermal hot MDF (H-MDF), were applied to 7085 aluminum alloy ingots. The results indicate that MC-MDF achieved anisotropy below 10% without losing ultimate tensile strength (UTS). Three-dimensional (3D) microstructure analysis suggested that the MC-MDF samples accumulated higher dislocation density and exhibited an enhanced recrystallization structure. The elongation of the vertical direction increased significantly, which lowered the directionality of MC-MDF and increased the effective utilization rate of forgings. Also, MC-MDF obtained a lower yield strength (YS) due to the forging temperature in exchange for higher work hardening and a ductility increase. The average 3D UTS, YS, and EL values of MC-MDF are 554 MPa, 472 MPa, and 13.4%, and the index value reflecting the anisotropy of EL decreased from 14.0% to 8.6% for H-MDF.
Effect of Polypropylene and Straw Fiber Materials on the Unconfined Compressive Strength of Tailings and Wasted Stone Mixed Backfill
Authors: Shi Xiuzhi , Shi Yuan , Chen Xin , Wang Wenyang
Published: January 2025

Ensuring the mechanical performance of backfill materials while reducing cementation costs is a key challenge in mine backfill research. To address this, fiber materials such as polypropylene (PP) fiber and rice straw (RS) fiber have been incorporated into cement-based mixtures for mine backfilling. This study investigates the effects of PP and RS fibers on the mechanical properties, flow characteristics, and microstructure of Tailings and Wasted Stone Mixed Backfill (TWSMB). A series of orthogonal experiments were designed to evaluate the influence of variables, including the cement–sand ratio, solid mass concentration, wasted stone mass concentration, fiber content, and fiber length on the TWSMB properties. The results indicate that the influence of cement–sand ratio and solid mass concentration have a more significant impact on strength than fibers, though the fibers show a stronger effect than the wasted stone mass concentration. Both fiber types enhanced the strength of the specimens, with PP fiber exhibiting a stronger reinforcing effect than RS fiber. Furthermore, the effect of PP fiber content was more pronounced than that of fiber length, whereas the opposite trend was observed for RS fiber. The optimum fiber parameter levels were determined for each type: PP fiber performed best at a mass concentration of 1.5% and a length of 6 mm, while RS fiber showed optimal performance at a mass concentration of 1.0% and a length of 5–10 mm. Macroscopic damage analysis indicated that the structural integrity and residual compressive strength of the TWSMB specimens were preserved even after surpassing the ultimate compressive strength, due to the crack-bridging effect of the fibers. Microstructural analysis showed that PP fiber-reinforced specimens exhibited a dense structure formed through reactions with other hydration products. In contrast, the surface of RS fibers was nearly fully encapsulated by hydration products, resulting in the formation of a physical skeleton structure. This study provides new insights into minimizing cement consumption and reducing backfilling costs in mining operations.
Construction and Properties of Wood-Based Tannin–Iron-Complexed Photothermal Material Populus tomentosa Carr.@Fe-GA for Solar Seawater Desalination System
Authors: Zhu Hongyan , Li Xinyu , Li Shijie , Wang Ximing , Ma Yabo , Zhang Jin , Ren Yunpeng , Zhao Jianguo
Published: January 2025

Desalinating seawater is a crucial method for addressing the shortage of freshwater resources. High-efficiency, low-cost, and environmentally friendly desalination technologies are key issues that urgently need to be addressed. This work used Populus tomentosa Carr. as a matrix material and prepared Populus tomentosa Carr.@Fe-GA through a complexation reaction to enhance the water evaporation rate and photothermal conversion efficiency of seawater desalination. The concentration of the impregnation solution was further refined, and the bonding mechanism along with the thermal stability of the composite photothermal material was investigated, including an assessment of their photothermal conversion efficiency. The research results indicate that the evaporation rate of water in a 3.5% NaCl solution for Populus tomentosa Carr.@Fe-GA under light intensity conditions of one sun reached 1.72 kg·m−2·h−1, which was an increase of 44.5% compared to untreated Populus tomentosa Carr. It achieved a photothermal conversion efficiency of 95.1%, an improvement of 53.6% over untreated Populus tomentosa Carr., and maintained stability and high evaporation performance (95.4%) even after prolonged rinsing. This work realizes the functional utilization of seawater desalination with Populus tomentosa Carr. and offers a novel approach for the development and use of wood-derived photothermal material.
An Investigation of the Usability of Alkali-Activated Blast Furnace Slag-Additive Construction Demolition Waste as Filling Material
Authors: Sarici Talha , Geckil Tacettin , Ok Bahadir , Aksoy Huseyin Suha
Published: January 2025

In this study, the usability of construction and demolition waste (CDW) aggregates as filling when stabilized with alkaline activator solution (AAS) and blast furnace slag (BFS) was investigated. The initial stage of this study involved determining the engineering properties of CDW by laboratory experiments. In the next stage, modified Proctor tests were performed to investigate the compaction behavior of CDW, to which 5% to 30% BFS was added with water or AAS. In the following stage, California bearing ratio experiments were performed to determine the mixture specimen with the highest strength. In the final stage, a weak soil layer was created in a test tank, and fillings of different thicknesses were built on it using CDW with and without additives in the determined optimum mixing ratio. Then, plate-loading tests were conducted using a model foundation to evaluate the load–deformation behavior of the fillings. The study’s results indicated that adding BFS with water or AAS to CDW increased strength. Furthermore, the addition of 20% BFS yielded the highest strength value, and the CDW aggregates with the added BFS increased the ultimate bearing capacity by up to 4.72 times compared to those without the additive.
Effect of Inherent Mg/Ti Interface Structure on Element Segregation and Bonding Behavior: An Ab Initio Study
Authors: Zhu Xiaodong , Cheng Kaiming , Wang Jin , Li Jianbo , Wang Jingya , Yu Huan , Zhou Jixue , Du Yong
Published: January 2025

To provide insight into the interface structure in Ti particle-reinforced Mg matrix composites, this study investigates the inherent Mg/Ti interface structure formed during the solidification of supercooled Mg melt on a (0001)Ti substrate using ab initio molecular dynamics (AIMD) simulations and density function theory (DFT) calculation. The resulting interface exhibits an orientation relationship of 0001Mg//0001Ti with a lattice mismatch of approximately 8%. Detailed characterizations reveal the occurrences of 0001Mg plane rotation and vacancy formation to overcome the lattice mismatch at the inherent Mg/Ti interface while allowing Mg atoms to occupy the energetically favorable hollow sites above the Ti atomic layer. The atomic diffusion behaviors of rare-earth elements Gd and Y at the Mg/Ti interface was examined using the climbing image nudged elastic band (CI-NEB) method, demonstrating a strong segregation tendency towards the interface promoted by the inherent interface structure. Additionally, the calculated Griffith work indicates enhanced interfacial adhesion due to the segregation of Gd and Y, which is beneficial for the mechanical properties of the composite.
A Study on the Impact of Temperature on the Anchoring Durability of Carbon-Fiber-Reinforced Polymer Cables
Authors: Wang Minzhe , Chen Bo , Jiang Haozhe , Zhuge Ping
Published: January 2025

To improve the application of carbon-fiber-reinforced polymers (CFRPs) in civil engineering, the long-term durability of CFRP anchorage systems has become a critical issue. Temperature fluctuations can significantly impact the bond performance between CFRPs and the load transfer medium (LTM), making it essential to understand the effects of temperature on the durability of CFRP anchorages. Therefore, this study investigates the influence of temperature on the durability of CFRP anchorages through aging tests on 30 epoxy-filled CFRP-bonded anchorage specimens, followed by pull-out tests. The long-term degradation of CFRP cable anchorage performances in representative regions of the globe was predicted using Arrhenius theory. The experimental results show that after long-term temperature exposure, the maximum bond strength of the CFRP-LTM interface in the anchoring zone degrades after 30 days but continues to increase after 150 days. In contrast, the residual bond strength of the CFRP-LTM interface in the anchorage zone continuously decreases over time, with the degradation rates gradually decreasing over time. Higher temperatures lead to more severe degradation of anchoring performance. Based on the experimental results, it is predicted that the anchoring performance of a CFRP cable anchorage system will reach degradation rates of 63.72%, 83.36%, and 94.73% after 50 years in regions with average annual temperatures of 0 °C, 10 °C, and 20 °C, respectively. Therefore, the temperature has a significant long-term impact on the anchoring performance of CFRP cable bonding systems, necessitating a more conservative design in higher-temperature areas.
Convergence and Dynamics of Schröder’s Method for Zeros of Analytic Functions with Unknown Multiplicity
Authors: Marcheva Plamena I. , Ivanov Stoil I.
Published: January 2025

In this paper, we investigate the local convergence of Schröder’s method for finding zeros of analytic functions with unknown multiplicity. Thus, we obtain a convergence theorem that provides exact domains of initial points together with error estimates to ensure the Q-quadratic convergence of Schröder’s method right from the first step. A comparison with the famous Newton’s method, based on the convergence and dynamics when it is applied to some polynomial and non-polynomial equations, is also provided.
Asthma Risk Prevalence and Associated Factors in Stunted Children: A Study Using Asthma Predictive Index
Authors: Sapartini Gartika , Wong Gary W. K. , Indrati Agnes Rengga , Kartasasmita Cissy B. , Setiabudiawan Budi
Published: January 2025

Background and Objectives: The prevalence of stunted children under 5 years in Indonesia is relatively high. Stunting is a significant risk factor for wheezing disorders. The asthma predictive index (API) identifies children with a recurrent wheezing disorder at risk of developing asthma during the first 3 years. However, the risk of developing asthma and its associated factors among stunted children has not been studied. This study aims to determine the asthma risk prevalence in stunted children via the API score and associated factors. Materials and Methods: This cross-sectional study was conducted at the Bandung District Health Center from October 2021 to January 2022. This study included stunted children aged 24–59 months living in Bandung District whose parents could answer the API and asthma risk factor questionnaires. Results: A total of 422 participants with an average age of 43.1 ± 9.7 months were included. Among the stunted children, 4.7% (20/422) met the positive API criteria, and 50.0% were malnourished (stunted–underweight). The participants with positive API results had a parental medical diagnosis of asthma (45%), eczema (10.0%), allergic rhinitis (20.0%), and wheezing apart from colds (40.0%) (p < 0.05). Significant risk factors for developing asthma in the participants with a positive API were dog ownership in the past 12 months and parents and siblings with allergic diseases. Conclusions: The asthma risk prevalence in stunted children was 4.7%. The associated risk factors included a history of allergic diseases in parents and siblings, as well as dog ownership; however, further investigation is needed.