bluuebunny/crossref_metadata_2025 huggingface dataset:
The Urban Spatial Pattern of the Pseudo-Colonial City in Southeast Asia: A Case Study of the Eastern Area of Bangkok, Thailand, during the Thai-Imperialism Period (1855-1932)
Authors: Tantivess Nicha , Edelman David J.
Published: May 2021

This article discusses the urban spaces of the pseudo-colonial city via the urban transformation in the eastern area of Bangkok between 1855 and 1932. During this period, the Thai royal government was under pressure from colonialism in the Southeast Asian region. To prevent colonization of the country, the kings aimed to strengthen their economic and political powers through administrative reform, educational development, infrastructure construction, and land commodification Thus, the urban spaces in Bangkok were significantly transformed. The eastern area became a transitional zone between the administrative center of the royal government and the commercial center where foreign traders resided. Furthermore, this transitional zone continued expanding into the area of rural communities, and, consequently, the traditional settlements of the local people gradually lost population.
Empathy and Our Contentment, Cooperation, and Compassion
Authors: Sanchez Horacio
Published: May 2021

Empathy is the cornerstone of healthy relationships and the ability to navigate complex social situations. The cognitive system that produces empathy, the left ventral striatum, ventrolateral prefrontal cortex, and supplemental motor area, motivates cooperation with others. Indications that empathy is on the decline should concern each individual because it is essential for our social and emotional wellbeing. Without empathy, we lose the ability to be compassionate. Empathy is many things, explaining why it can produce contradictory outcomes simultaneously. The evolutionary mandate of empathy might be the source of racial strife as well as the key to achieving racial harmony.
Three body abrasive wear assessment of novel jute/natural rubber flexible green composite
Authors: Mahesh Vishwas , Joladarashi Sharnappa , Kulkarni Satyabodh M
Published: May 2021

Determining the resistance to abrasion of the flexible cladding for armours and automobile structural components with the aid of lab scale tests has become increasingly important. In the present study, three body wear behaviour of flexible green composites comprising of jute in woven fabric form with interleaved natural rubber sheets bonded through rubberized B stage cured Pre pegs have been studied. Flexible composites are fabricated in three different configurations having different layers of jute and rubber. The present study makes use of silica sand as the abrasive medium. The specific wear rate along with loss in mass and volume of the composite due to wear is determined and it was found that specific wear rate is dependant of the sliding distance. Comparing the specific wear rate of all the three stacking sequences, it was found that JRJ stacking sequence provides better wear resistance. Compliant and tough nature of the rubber makes it hard to wear it out through tearing action and also the wear resistance of flexible composites is enhanced with inclusion of rubber. Mechanism of wear in each of the constituent used is studied. The present study serves as a benchmark work for the future research in this area.
Cure kinetics and properties of high-performance epoxy thermosets cured with active ester-terminated poly (aryl ether ketone)
Authors: Meng Huifa , Zhang Qian , Lu Maoping , Qu Zhencai , Chen Bing , Xu Chang-an , Lu Mangeng
Published: May 2021

Benzene-1,3,5-triyl tribenzoate (TBB), both 3,5-bis(benzoyloxy)benzoate-terminated poly (aryl ether ketone) oligomers (BPAPK and TMPK), containing active ester (Ph−O−(C=O)− structure), were prepared and served as curing agents for dicyclopentadiene novoalc epoxy (DCPD). The curing kinetics and properties of three epoxy thermosets were systematically investigated. The model reaction of TBB and glycidyl phenyl ether was designed to understand the curing mechanism of oxirane ring with active ester. TMPK/DCPD displays the lowest reaction activation energy, which is the result of the combined influence of free volume and diffusion. In addition, TMPK/DCPD has the highest Tg value (218°C), which enhances 34.6% and 42.5% compared with BPAPK/DCPD and TBB/DCPD, respectively. Meanwhile, TMPK/DCPD also shows superior dielectric and water resistance properties due to no secondary alcohol generated after curing and hydrophobic tetramethyl-substituted biphenyl structure. Herein, TMPK/DCPD as high-performance epoxy thermosets has potential applications in electronic packaging fields.
Functional joint models for chronic kidney disease in kidney transplant recipients
Authors: Dong Jianghu (James) , Cao Jiguo , Gill Jagbir , Miles Clifford , Plumb Troy
Published: May 2021

This functional joint model paper is motivated by a chronic kidney disease study post kidney transplantation. The available kidney organ is a scarce resource because millions of end-stage renal patients are on the waiting list for kidney transplantation. The life of the transplanted kidney can be extended if the progression of the chronic kidney disease stage can be slowed, and so a major research question is how to extend the transplanted kidney life to maximize the usage of the scarce organ resource. The glomerular filtration rate is the best test to monitor the progression of the kidney function, and it is a continuous longitudinal outcome with repeated measures. The patient’s survival status is characterized by time-to-event outcomes including kidney transplant failure, death with kidney function, and death without kidney function. Few studies have been carried out to simultaneously investigate these multiple clinical outcomes in chronic kidney disease stage patients based on a joint model. Therefore, this paper proposes a new functional joint model from this clinical chronic kidney disease study. The proposed joint models include a longitudinal sub-model with a flexible basis function for subject-level trajectories and a competing-risks sub-model for multiple time-to event outcomes. The different association structures can be accomplished through a time-dependent function of shared random effects from the longitudinal process or the whole longitudinal history in the competing-risks sub-model. The proposed joint model that utilizes basis function and competing-risks sub-model is an extension of the standard linear joint models. The application results from the proposed joint model can supply some useful clinical references for chronic kidney disease study post kidney transplantation.
Doing Dirty Theology: How Ensoiled Humans Participate in the Flourishing of All Earthlings
Authors: Biddington Terry
Published: May 2021

Traditional theological ideas, language and imagery tend to take their cue and inspiration from the Beyond: from heaven; the transcendent realm and all that is ‘above us’ that we might inspire to attain. But, given that all life arises from and is dependent upon the soil/earth, what possibilities might exist for new ‘ensoiled’ forms of thinking and practice? We are all earthlings and groundlings and our human qualities and spiritual sensitivities and aspirations must, in an evolutionary sense, arise from our connectivity to the soil and earth. What then can the soil and the life it contains teach us about living harmoniously as part of a community of planetary flourishing? This article will explore how a theology influenced by the soil – an ‘edapho-theology’ – might offer fresh perspectives for re-engaging with the need to create a sustainable future for all life on the planet.
Influence of Economic Benefits and Social Interaction on Buyer Participation in a Rural Retail Institution: Study of an Indian Periodic Market
Authors: Velayudhan Sanal Kumar
Published: May 2021

Retail institutions offer economic and social benefits to the participants in a market. It is expected that in a less developed economy the social factors influence economic behaviour much more than in developed economies. The rural markets offer increased opportunities for the influence of social factors on economic transactions. This study examined the case of a rural periodic market. To ensure reliability the case study protocol questions reflected propositions developed on the research questions. It was expected that the participants would exhibit the influence of social relations in their market transactions. The results indicated that the economic benefits than social considerations influenced participant behaviour in the rural periodic market. Contrary to expectations not all consumers in a less developed economy exhibit social embeddedness in economic behaviour. Implications are for policymakers involved in planning and regulating rural markets. They need to take into consideration the differing behaviour of consumer groups in designing or regulating retail markets. This study examining the social embeddedness of buyer behaviour in the rural retail context of a less developed economy is presumably the first.
Embodied Education: A Pathway Towards More Integrated Learning
Authors: Singh Akhil Kumar , V. Hari Narayanan
Published: May 2021

This study seeks to argue that the embodied approach to cognition provides a comprehensive theoretical framework to revise some of our educational practices. Any educational activity presupposes some underlying assumption about human nature. Current dominant mainstream educational set-up is based upon disembodied accounts of the human mind, which creates a rift between learners and their environment. It results in exam-oriented and achievement-based learning which is not conducive for the development of critical thinking and exploratory mindset among children. On the other hand, an embodied approach stresses the role of the full body and the rest of the environment in the learning process, and this is of immense relevance to devise better pedagogical practices. In this study, we shall try to explain how embodiment can help reduce the psychological gap between the learner and the environment, thereby making education more integrated and inherently meaningful.
What if? Fine-tuning the expectations of business simulation technology through the lens of philosophical counterfactual analysis
Authors: Eabrasu Marian
Published: May 2021

Great technological leaps in computational capacity and machine autonomy have increased the business community’s expectations of simulators. In joining the conversation on simulators’ ability to reproduce the reality of actual, possible, past, and future worlds, this paper draws on the literature in analytical philosophy on counterfactuals. It identifies three functions of simulations (training, advising, and forecasting) and further inquires into their ontological and epistemological assumptions to show how they limit the quest for reality of higher-performance simulators in each of these three areas. This argument is not only meant to contribute to adjusting scholars’ and practitioners’ expectations and uses of simulations; it also calls for a more in-depth and critical study of the social implications of relying on them.
How set switching affects the use of context-appropriate language by autistic and neuro-typical children
Authors: Malkin Louise , Abbot-Smith Kirsten
Published: May 2021

Autistic children have difficulties in adapting their language for particular listeners and contexts. We asked whether these difficulties are more prominent when children are required to be cognitively flexible, when changing how they have previously referred to a particular object. We compared autistic ( N = 30) with neuro-typical 5- to 7-year-olds. Each child participated in two conditions. In the switch condition, the same animal had to be re-described across trials to be appropriately informative (e.g. a participant could appropriately describe a picture as ‘dog’ on one trial but later the participant needed to re-describe the same picture as ‘spotty dog’ to differentiate it from a co-present black dog). In the no-switch condition, no picture needed to be re-described. Nonetheless, the conditions were matched regarding the requirement to use both complex (e.g. spotty cat) versus simple expressions (e.g. horse). Autistic children were more over-informative than peers even prior to the requirement to re-describe an animal. Overall, we found a main effect of the switch condition and no interaction with group. Switching a description hinders the ability of children to be appropriately informative. As autistic children are generally less appropriately informative, the requirement to switch leads to particularly poor performance in autism.

Lay abstract

The way autistic individuals use language often gives the impression that they are not considering how much information listeners need in a given context. The same child can give too much information in one context (e.g. saying ‘the big cup’ with only one cup present) and too little information in another context (e.g. entering a room and announcing ‘the red one’ when the listener has no prior knowledge regarding what this refers to). We asked whether many autistic children particularly struggle to tailor their language appropriately in situations where this means changing how they have previously described something. That is, if a speaker has recently described an object as ‘the cup’, the need to switch to describing it as ‘the big cup’ could hinder the speaker’s ability to use language in a context-appropriate way. We found that switching descriptions indeed makes it more difficult for children to use language in a context-appropriate way, but that this effect did not play out differently for autistic versus neuro-typical children. Autistic children were, however, less likely to provide a context-appropriate amount of information overall than were neuro-typical peers. The combination of these effects meant that when object re-description was required, autistic children only produced an appropriate description half the time. In contrast, without a requirement to re-describe, autistic children could indeed take listener informational needs into account. Applied professionals should consider whether a requirement to change the way the child has previously said something may hinder a child’s ability to communicate effectively.
What are the risks of Virtual Reality data? Learning Analytics, Algorithmic Bias and a Fantasy of Perfect Data
Authors: Carter Marcus , Egliston Ben
Published: May 2021

Virtual reality (VR) is an emerging technology with the potential to extract significantly more data about learners and the learning process. In this article, we present an analysis of how VR education technology companies frame, use and analyse this data. We found both an expansion and acceleration of what data are being collected about learners and how these data are being mobilised in potentially discriminatory and problematic ways. Beyond providing evidence for how VR represents an intensification of the datafication of education, we discuss three interrelated critical issues that are specific to VR: the fantasy that VR data is ‘perfect’, the datafication of soft-skills training, and the commercialisation and commodification of VR data. In the context of the issues identified, we caution the unregulated and uncritical application of learning analytics to the data that are collected from VR training.
Video gaming as craft consumption
Authors: Brock Tom , Johnson Mark R
Published: May 2021

This article repurposes Campbell’s (2005) concept of ‘the craft consumer’ to generate a new theory of video game consumption, which proposes that we identify the material practices typically associated with craft labour within acts of digital play. We draw on case studies from popular and community-driven video game titles including Dark Souls and Super Mario Maker to make our argument, suggesting that a grasp of the controls initiates material practices, like repetition, which provide the groundwork for craft skill. It is from this position that we argue that consumers initiate a craft-like ‘dialogue’ (Sennett R (2008) The Craftsman. London: Yale University Press.) with the game’s design that reveals the experimental and creative nature of video game consumption. Importantly, these case studies provide evidence to meet with Campbell’s definition of ‘craft consumption’ as an (1) ‘ensemble activity’ and (2) as a ‘collection’ of handmade things. The result is a better understanding of the consumer as someone who initiates experiences of skilled labour and creative self-expression through the craft of playing a video game. This article presents a new understanding of the (gaming) consumer whilst also challenging the idea that the experience of ‘craft consumption’ is typically reserved for the middle or professional classes, as Campbell maintains.
Periprocedural Outcomes of Popliteal vs Upper Extremity Access in the Treatment of Superficial Femoral Artery Occlusive Disease
Authors: Lin Stephanie K. , Conway Allan M. , Zhou Anan , Nguyen Tran Nhan , Qato Khalil , Northfield Elizabeth , Giangola Gary , Carroccio Alfio
Published: May 2021

Purpose:

Percutaneous lower extremity revascularization is being performed via upper extremity, pedal, or popliteal access with increasing frequency. This study aimed to compare periprocedural outcomes of popliteal (POA) and upper extremity (UEA) access for the treatment of isolated superficial femoral artery (SFA) occlusive disease.

Materials and Methods:

A retrospective cohort study compared the outcomes of patients undergoing primary percutaneous intervention of SFA occlusive disease with POA or UEA using the Vascular Quality Initiative database from December 2010 to June 2019. Our primary endpoint was technical success. Secondary endpoints included factors associated with perioperative complications.

Results:

A total of 349 patients underwent isolated SFA intervention through the popliteal, radial, or brachial artery. UEA was performed in 188 (53.9%) patients and POA in 161 (46.1%). Technical success with TASC A lesions was 95.8% and with TASC D lesions, 65.0%. POA had a higher proportion of TASC D lesions (24.8% vs 10.6%, p<0.001), and larger (≥7 Fr) sheath size (14.3% vs 2.7%, p<0.001). UEA had a higher proportion of no calcification (27.1% vs 11.2%, p<0.001), and smaller (4–5 Fr) sheath size (46.8% vs 34.8%, p=0.023). There was no difference in technical success between UEA and POA (88.8% vs 84.5%, p=0.230), which was also seen on multivariable analysis (p=0.985). Univariate analysis revealed technical failure was associated with TASC D lesions (45.7% vs 12.9%, p<0.001) and the presence of severe calcifications (39.1% vs 17.5%, p=0.002). Multivariable analysis confirmed technical failure was associated with degree of calcification (OR, 2.4; 95% CI, 1.18 to 4.89; p=0.016) and TASC D lesions (OR, 5.01; 95% CI, 2.45 to 10.24; p<0.001). Postoperative complications were associated with UEA on univariate (p=0.041) and multivariate analysis (OR, 2.08; 95% CI, 0.80 to 5.37; p=0.016). Access site complications were also associated with UEA compared to POA (4.3% vs 0.0%, p=0.027).

Conclusions:

There is no difference in technical success between UEA and POA when treating isolated SFA occlusive disease, and UEA is associated with a higher complication rate. Technical success is dependent on calcification and TASC II classification. Based on similar technical success rates and low complication rates, POA should be considered as a viable alternative to UEA when planning endovascular interventions.
Vancomycin Presoaking of the Graft Appears to Prevent Infection After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis
Authors: Figueroa Francisco , Figueroa David , Calvo Rafael , Vaisman Alex , Nuñez Marilaura , Putnis Sven
Published: May 2021

Background: Vancomycin presoaking of the graft has been shown to decrease infection rates in some case series of anterior cruciate ligament (ACL) reconstruction. Purpose: We sought to substantiate the efficacy of vancomycin presoaked grafts for the prevention of infection after ACL reconstruction. Methods: We performed a systematic review of Medline and OVID to assess the incidence of postoperative infection in studies comparing patients undergoing ACL reconstruction with the use of vancomycin presoaked ACL grafts and a control group of patients undergoing ACL reconstruction without the use of presoaked grafts. The efficacy of vancomycin presoaking was calculated using the Agresti-Coull confidence interval. Relative risk (RR) was calculated for every study and the total sample. Results: The 11 studies that met inclusion criteria comprised 24,298 patients. In patients with vancomycin presoaking of the graft, 1 infection was reported in 8764 cases (0.01% rate). In the studies with control groups that did not have vancomycin presoaked grafts, there were 125 infections in 15,534 ACL reconstructions (0.8% rate). The efficacy of vancomycin presoaking in preventing infection after ACL reconstruction was 99.9% (0.999%–1.000% CI). The overall RR obtained was 0.07 (0.03–0.16 CI). All included studies were retrospective cohort studies (level III). Conclusions: Vancomycin presoaking of the graft has been shown to decrease infection rates after ACL reconstruction in studies of low evidence level. This suggests the need for prospective randomized controlled trials addressing this issue so that recommendations on the routine use of vancomycin presoaking of ACL grafts can be made with confidence.
Use of intravenous cangrelor and stenting in acute ischemic stroke interventions: a new single center analysis and pooled-analysis of current studies
Authors: Paul Alexandra R , Entezami Pouya , Holden Devin , Field Nicholas , Dalfino John , Boulos Alan
Published: May 2021

Introduction

Emergent stenting of both extra- and intracranial occlusions during acute ischemic stroke procedures is complicated by the need for immediate platelet inhibition to prevent thromboembolic complications. IV cangrelor is a relatively new antiplatelet that was initially approved for coronary interventions. Five prior case series have been published evaluating the results of IV cangrelor in neurointerventional procedures. We sought to combine the data from all prior studies and analyze only ischemic stroke interventions.

Methods

A prospectively maintained database was reviewed to identify all cases of IV cangrelor administration during acute ischemic stroke intervention. Nine additional patients were identified who have not been previously published. In addition, a literature search was performed to identify five prior publications of cangrelor in neurointervention. The data from these was combined with our institution in a pooled-analysis.

Results

Overall, 129 patients who received IV cangrelor during an acute ischemic stroke intervention were identified. The asymptomatic intracranial hemorrhage rate was 12.6%(11/87). The symptomatic intracranial hemorrhage rate was 6.2% (8/129). The rate of retroperitoneal hematoma and gastrointestinal bleeding were also low (1.5% and 0.8%, 2/129 and 1/129). There was one case of intraprocedural thromboembolic complication (0.8%) and no cases of intraprocedural in-stent thrombosis(0%).

Conclusions

IV cangrelor during acute ischemic stroke intervention appears to be safe, with a symptomatic intracranial hemorrhage rate of 6.2%. More research is needed to determine the ideal dosing regimen.
Including the animal standpoint in critical public relations research
Authors: Almiron Núria , Fernández Laura
Published: May 2021

In this paper we argue that adopting critical animal studies perspectives in critical public relations can not only be very fruitful, but that it is also a necessity if the aims of the latter are to be achieved. To this end, this text introduces the challenges and opportunities that the field of critical animal studies brings to critical public relations studies. First, a short explanation of what critical animal studies is and why it can contribute to critical public relations studies is provided. Then the main fields of research where this contribution can be most relevant are discussed, including ethics, discourse studies and political economy. The final aim of this theoretical paper is to expand research within the field of critical public relations by including a critical animal studies approach. Eventually, the authors suggest that embracing the animal standpoint in critical public relations is an essential step to furthering the study of power, hegemony, ideology, propaganda or social change and to accomplishing the emancipatory role of research.
A galaxy of apps: Mobile app reliance and the indirect influence on political participation through political discussion and trust
Authors: Johnson Thomas J. , Saldaña Magdalena , Kaye Barb K.
Published: May 2021

The power of app-driven mobile phones was first unleashed in 2011 when they were used to mobilize protesters and gain support for political movements in the United States and abroad. Mobile devices have since become the bedrock of political activism. To examine the influence of app reliance on offline and online political participation, this study builds on the Orientation-Stimulus-Reasoning-Orientation-Response (O-S-R-O-R) model by (a) applying the model to mobile apps, (b) testing whether trust in, and reliance on political discussion are mediators between reliance on apps and political participation, and (c) using trust in both offline and online discussion as measures of cognitive elaboration. This study’s path model suggests that app reliance is related to online political discussion, which, in turn, is related to online political participation, but not offline participation. Although both offline and online discussion are linked to offline and online trust in political discussion, trust in political discussion does not influence either offline or online political participation.
A case report: Treatment of chronic diabetic foot ulcer with Hyperbaric Oxygen Therapy
Authors: Jeffrey CW Chau , Joe KS Leung
Published: May 2021

Diabetes mellitus effects around 10% of the whole population and unhealed diabetic foot ulcer is one of the most debilitating and economically burdensome conditions. This condition is commonly seen by different specialists including physicians, orthopaedic surgeons and vascular surgeons. We present a case of unhealed diabetic foot ulcer which has been treated in our Hyperbaric Oxygen Therapy (HBOT) centre. We also review the literature with respect to management strategy and rationale of hyperbaric oxygen therapy for diabetic foot ulcers.
Degrees of Support: State Spending on Higher Education and Public Postsecondary Degrees across State Legislatures, 2005 and 2014
Authors: Shorette Kristen , Thiele Megan , Bolzendahl Catherine
Published: May 2021

U.S. state spending on higher education represents a sizable, but highly variable, portion of budget expenditures. Preliminary research supports a positive relationship between the percentage of state legislators who hold public degrees and state funding for higher education. In this study, the authors test whether this finding is consistent over time by using panel modeling to analyze the educational compositions of state legislatures in 2005 and 2014. Generalized least squares regression models with robust standard errors clustered by state- and year-specific intercepts indicate a significantly positive relationship between the proportion of publicly educated state legislators and state spending on higher education. This relationship is consistent across models with numerous robustness checks and political, economic, and structural controls. Given the smaller number of publicly educated legislators in 2014, the findings suggest that spending on higher education would have increased to a larger extent had the educational composition of the legislatures remained constant.
Simultaneous learning of individual microRNA-gene interactions and regulatory comodules
Authors: Roth Michael , Jain Pranjal , Koo Jinkyu , Chaterji Somali
Published: May 2021

Background

MicroRNAs (miRNAs) function in post-transcriptional regulation of gene expression by binding to target messenger RNAs (mRNAs). Because of the key part that miRNAs play, understanding the correct regulatory role of miRNAs in diverse patho-physiological conditions is of great interest. Although it is known that miRNAs act combinatorially to regulate genes, precise identification of miRNA-gene interactions and their specific functional roles in regulatory comodules remains a challenge. We developedTheia, an effective method for simultaneously predicting miRNA-gene interactions and regulatory comodules, which group functionally related miRNAs and genes via non-negative matrix factorization (NMF).

Results

We applyTheiato RNA sequencing data from breast invasive carcinoma samples and demonstrate its effectiveness in discovering biologically significant regulatory comodules that are significantly enriched in spatial miRNA clusters, biological pathways, and various cancers.

Conclusions

Theiais a theoretically rigorous optimization algorithm that simultaneously predicts the strength and direction (i.e., up-regulation or down-regulation) of the effect of modules of miRNAs on a gene. We posit that ifTheiais capable of recovering known clusters of genes and miRNA, then the clusters found by our method not previously identified by literature are also likely to have biological significance. We believe that these novel regulatory comodules found by our method will be a springboard for further research into the specific functional roles of these new functional ensembles of miRNAs and genes,especially those related to diseases like breast cancer.
Analysis of differentially expressed Sclerotinia sclerotiorum genes during the interaction with moderately resistant and highly susceptible chickpea lines
Authors: Mwape Virginia W. , Mobegi Fredrick M. , Regmi Roshan , Newman Toby E. , Kamphuis Lars G. , Derbyshire Mark C.
Published: May 2021

Background

Sclerotinia sclerotiorum, the cause of Sclerotinia stem rot (SSR), is a host generalist necrotrophic fungus that can cause major yield losses in chickpea (Cicer arietinum) production. This study used RNA sequencing to conduct a time course transcriptional analysis of S. sclerotiorum gene expression during chickpea infection. It explores pathogenicity and developmental factors employed by S. sclerotiorum during interaction with chickpea.

Results

During infection of moderately resistant (PBA HatTrick) and highly susceptible chickpea (Kyabra) lines, 9491 and 10,487 S. sclerotiorum genes, respectively, were significantly differentially expressed relative to in vitro. Analysis of the upregulated genes revealed enrichment of Gene Ontology biological processes, such as oxidation-reduction process, metabolic process, carbohydrate metabolic process, response to stimulus, and signal transduction. Several gene functional categories were upregulated in planta, including carbohydrate-active enzymes, secondary metabolite biosynthesis clusters, transcription factors and candidate secreted effectors. Differences in expression of four S. sclerotiorum genes on varieties with different levels of susceptibility were also observed.

Conclusion

These findings provide a framework for a better understanding of S. sclerotiorum interactions with hosts of varying susceptibility levels. Here, we report for the first time on the S. sclerotiorum transcriptome during chickpea infection, which could be important for further studies on this pathogen’s molecular biology.
Quality assessment tools used in systematic reviews of in vitro studies: A systematic review
Authors: Tran Linh , Tam Dao Ngoc Hien , Elshafay Abdelrahman , Dang Thao , Hirayama Kenji , Huy Nguyen Tien
Published: May 2021

Background

Systematic reviews (SRs) and meta-analyses (MAs) are commonly conducted to evaluate and summarize medical literature. This is especially useful in assessing in vitro studies for consistency. Our study aims to systematically review all available quality assessment (QA) tools employed on in vitro SRs/MAs.

Method

A search on four databases, including PubMed, Scopus, Virtual Health Library and Web of Science, was conducted from 2006 to 2020. The available SRs/MAs of in vitro studies were evaluated. DARE tool was applied to assess the risk of bias of included articles. Our protocol was developed and uploaded to ResearchGate in June 2016.

Results

Our findings reported an increasing trend in publication of in vitro SRs/MAs from 2007 to 2020. Among the 244 included SRs/MAs, 126 articles (51.6%) had conducted the QA procedure. Overall, 51 QA tools were identified; 26 of them (51%) were developed by the authors specifically, whereas 25 (49%) were pre-constructed tools. SRs/MAs in dentistry frequently had their own QA tool developed by the authors, while SRs/MAs in other topics applied various QA tools. Many pre-structured tools in these in vitro SRs/MAs were modified from QA tools of in vivo or clinical trials, therefore, they had various criteria.

Conclusion

Many different QA tools currently exist in the literature; however, none cover all critical aspects of in vitro SRs/MAs. There is a need for a comprehensive guideline to ensure the quality of SR/MA due to their precise nature.
Impact of second forward-view examination on adenoma detection rate during unsedated colonoscopy: a randomized controlled trial
Authors: Shan Keshu , Lu Hongpeng , Zhang Zhixin , Xie Jiarong , Xu Lu , Wang Weihong , Hu Chunjiu , Xu Lei
Published: May 2021

Objectives

Colorectal cancer on the right side of the colon has been suggested to be harder to detect by colonoscopy. The aim of this study was to evaluate whether a second forward-view examination of the right side of the colon could increase the adenoma detection rate (ADR) and/or polyp detection rate (PDR).

Methods

This was a single-centre randomized controlled trial. Patients undergoing colonoscopy were recruited and randomly assigned to the second forward-view examination (SFE) group, in which the right side of the colon was examined twice or the traditional colonoscopy (TC) group in which the colonoscopy was performed in a standard manner. The primary outcome was the ADR of right colon. The overall PDR and ADR, PDR of the right colon, per-adenoma miss rate of the right colon, and advanced lesion detection rate were also recorded and compared.

Results

A total of 392 patients were included in the study (SFE group 197 vs. TC group 195). The ADR and PDR of the right colon in the SFE group were significantly higher than those in the TC group (ADR 10.7% vs. 5.1%; P = 0.042); PDR 17.8% vs. 9.7%, P = 0.021). No significant difference was found in overall PDR/ADR, or advanced lesion detection rate between the two groups.

Conclusions

This prospective controlled study revealed that a second forward-view examination could modestly increase the ADR and PDR of the right colon during unsedated colonoscopies. This simple, safe and time-effective technique might be recommended for routine unsedated colonoscopy.

Trial registration: Clinical Trials.gov, NCT03619122. Registered on 7/8/2018.
Retrieval of lost patients in the system for hepatitis C microelimination: a single-center retrospective study
Authors: Yen Hsu-Heng , Su Pei-Yuan , Liu I.-L.ing , Zeng Ya-Huei , Huang Siou-Ping , Hsu Yu-Chun , Hsu Po-Ke , Chen Yang-Yuan
Published: May 2021

Background

Hepatitis C virus (HCV) is one of the major causes of chronic liver disease, cirrhosis, and liver cancer. Most of the infected people have no clinical symptoms. The current strategy for HCV elimination includes test and treatment. In this study, we aimed to evaluate the campaign for retrieving patients who were lost to follow-up, for subsequent re-evaluation.

Methods

From January 2020 to October 2020, patients who had prior tests for positive anti-HCV antibody in 2010–2018 in our hospital were enrolled for our patient callback campaign. Patients who had unknown HCV RNA status or no documented successful antiviral therapy history were selected for anti-HCV therapy re-evaluation. To facilitate patient referral in the hospital, we developed an electronic reminding system and called the candidate patients via telephone during the study period.

Results

Through the hospital electronic system, 3783 patients with positive anti-HCV antibody documentation were identified. Among them, 1446 (38.22%) had tested negative for HCV RNA or had anti-HCV therapy, thereby excluded. Of the 2337 eligible patients, 1472 (62.99%) were successfully contacted and called back during the study period for subsequent HCV RNA testing and therapy. We found that 42.19% of the patients had positive HCV RNA and 88% received subsequent anti-HCV therapy.

Conclusions

A significant number of patients with positive HCV serology were lost for HCV confirmatory test or therapy in the hospital. Therefore, this targeted HCV callback approach in the hospital is feasible and effective in achieving microelimination.
Systemic lupus erythematosus complicated by Crohn’s disease with rectovaginal fistula
Authors: Yeh Heng , Wu Ren-Chin , Tsai Wen-Sy , Kuo Chia-Jung , Su Ming-Yao , Chiu Cheng-Tang , Le Puo-Hsien
Published: May 2021

Background

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease, and few cases combine with Crohn’s disease. We present the first SLE patient concurrent with Crohn’s disease and rectovaginal fistula. She was successfully treated with vedolizumab and surgical intervention. Besides, she also had a rare opportunistic infection, cryptococcal pneumonia, in previous adalimumab treatment course.

Case

A 57 year-old female had SLE in disease remission for 27 years. She suffered from progressive rectal ulcers with anal pain and bloody stool, and Crohn’s disease was diagnosed. She received adalimumab, but the lesion still progressed to a rectovaginal fistula. Besides, she suffered from an episode of cryptococcal pneumonia under adalimumab treatment course. Therefore, we changed the biologics to vedolizumab, and arrange a transverse colostomy for stool diversion. She had clinical remission without active inflammation, but the fistula still persisted. Then, she received a restorative proctectomy with colo-anal anastomosis and vaginal repair. Follow-up endoscopy showed no more rectal ulcers or fistula tracts, and contrast enema also noted no residual rectovaginal fistula.

Conclusion

When a SLE patient had unusual rectal ulcers, Crohn’s disease should be considered. Biologics combined with surgical intervention is an optimal solution for Crohn’s disease with rectovaginal fistula. Although cryptococcal pneumonia is a rare opportunistic infection in the biological treatment, we should always keep it in mind.
Attitudes and perspectives of older adults on technologies for assessing frailty in home settings: a focus group study
Authors: Bian Chao , Ye Bing , Hoonakker Anna , Mihailidis Alex
Published: May 2021

Background

The rapid development of technology such as sensors and artificial intelligence in recent years enables monitoring frailty criteria to assess frailty early and accurately from a remote location such as a home. However, research shows technologies being abandoned or rejected by users due to a lack of compatibility and consumer involvement in selecting their assistive technology devices. This study aims to understand older adults’ perceptions and preferences of technologies that can potentially assess frailty at home.

Methods

This study collected qualitative data through focus group meetings with 15 participants ages 65 and older. Researchers asked participants questions to achieve the goal of understanding their attitudes on the technologies. These questions include (1) the concerns or barriers of installing and using the presented technology in daily life at home, (2) the reasons participants like or dislike a particular technology, (3) what makes a specific technology more acceptable, and (4) participants’ preferences in choosing technologies. Data were transcribed, coded and categorized, and finally synthesized to understand the attitudes towards presented technologies.

Results

Three focus group sessions were conducted with five participants in each session. In the findings, the attitudes and perspectives of participants on the technologies for assessing frailty were categorized into four themes: (A) general attitude towards using the technologies, (B) conditions for accepting certain technologies, (C) existing living habits or patterns related to using the technologies, and (D) constructive suggestions related to the technologies.

Conclusions

Participants generally had positive attitudes towards allowing the technologies to be installed and used at their homes. They would accept some technologies if used under certain conditions. However, questions and concerns remain, such as concerns about privacy, functionality, and aesthetics. The study also found that older adults’ living habits or patterns could affect the design and use of technology. Lastly, many valuable suggestions have been made by participants. These perspectives and insights can help improve the design and adoption of home-based frailty assessment technologies among older adults.
Study of the collagen type VI alpha 3 (COL6A3) gene in Parkinson’s disease
Authors: Jin Chong-Yao , Zheng Ran , Lin Zhi-Hao , Xue Nai-Jia , Chen Ying , Gao Ting , Yan Yi-Qun , Fang Yi , Yan Ya-Ping , Yin Xin-Zhen , Tian Jun , Pu Jia-Li , Zhang Bao-Rong
Published: May 2021

Background

To date, the genetic contribution to Parkinson’s disease (PD) remains unclear. Mutations in the collagen type VI alpha 3 (COL6A3) gene were recently identified as a cause of isolated dystonia. Since PD and dystonia are closely related disorders with shared clinical and genetic characteristics, we explored the association between COL6A3 and PD in a Chinese cohort.

Methods

We performed genetic screening of COL6A3 in a Chinese cohort of 173 patients with sporadic PD and 200 healthy controls. We identified variants that are likely to have pathogenic effects based on: 1) a minor allele frequency of < 0.01; and 2) the variant being recognized as deleterious by at least 15 different in silico predicting tools. Finally, we tested the aggregate burden of COL6A3 on PD via SKAT-O analysis.

Results

First, we found compound heterozygous COL6A3 gene mutations in one early-onset PD patients. Then, we explored whether COL6A3 variants contributed to increased risk of developing PD in a Chinese population. We detected 21 rare non-synonymous variants. Pathogenicity predictions identified 7 novel non-synonymous variants as likely to be pathogenic. SKAT-O analysis further revealed that an aggregate burden of variants in COL6A3 contributes to PD (p = 0.038).

Conclusion

An increased aggregate burden of the COL6A3 gene was detected in patients with PD.
Multimodal imaging of bilateral ischemic retinal vasculopathy associated with Berger’s IgA nephropathy: case report
Authors: El Matri Khaled , Amoroso Francesca , Zambrowski Olivia , Miere Alexandra , Souied Eric H.
Published: May 2021

Background

Berger’s IgA nephropathy (IgAN) is the most common primary glomerulonephritis. However, some rare cases of retinal manifestations have been described, with only two cases of retinal vasculopathy reported in the literature.

Here we report an uncommon case of bilateral ischemic retinal vasculopathy associated with Berger IgAN, evaluated with complete multimodal imaging including ultra-wide field (UWF) imaging and swept source optical coherence tomography angiography (SS-OCTA).

Case presentation

A 51-year-old woman with a history of Berger’s IgA nephropathy complained of visual impairment in both eyes. Fundus examination showed bilateral peripapillary arterial attenuation and perivascular sheathing, associated to perifoveal telangiectatic lesions. There was a central scotoma in the perimetry of the right eye and peripheral visual field defect in the left eye. Full-field electroretinogram revealed significantly reduced oscillatory potentials. Spectral domain optical coherence tomography showed multiple focal areas of thinning of the inner retina, indicating long-lasting vascular occlusion lesions. UWF fluorescein angiography showed the presence of bilateral vasculitis, diffuse capillary leakage, macular ischemia and telangiectasia. SS-OCTA better highlighted the macular ischemia and vascular anomalies layer-by-layer.

Conclusions

Retinal vasculopathy is a very rare condition observed in IgA nephropathy. To our knowledge, this is the first report of complete multimodal functional and structural imaging. UWF imaging was very useful for accurate and comprehensive disease assessment, and OCTA was able to assess posterior pole vascular lesions.
Spatial distribution of under immunization among children 12–23 months old in Butajira HDSS, southern Ethiopia
Authors: Ketsela Admassu , Gebreyesus Seifu Hagos , Deressa Wakgari
Published: May 2021

Background

Immunization is essential to prevent between 2 and 3 million deaths globally each year and it is widely accepted that it is one of the most cost-effective health interventions. Despite all its advantages, immunization in Ethiopia is still far from the target set by the United Nations Sustainable Development Goals to achieve universal immunization by all countries in 2030. The 2016 Ethiopian Demographic and Health Survey (EDHS) reported an overall full immunization rate of only 38.3%. The objective of this study was to evaluate the spatial distribution of under immunization in 12 to 23 months old children and further identify the determinants of under immunization clustering in the Butajira Health and Demographic Surveillance Site (HDSS).

Methods

We conducted a community based sectional survey from March to April, 2016 in Butajira HDSS. We collected data on immunization status from a total of 482 children between the age of 12 to 23 months. We randomly selected household and interviewed mothers and /or observed vaccination cards when available to collect data on child’s immunization status. We also collected the geographic location of all villages within the ten Kebeles using a Handheld Global Positioning System (GPS) (Garmin GPSMAP®). We analyzed the spatial distribution of under immunization and clustering using the SatScan® software which employs a purely spatial Bernoulli’s model. We also ran a logistic regression model to help evaluate the causes of clustering.

Results

We found that only 22.4% [95% CI: 18.9, 26.4%] of children were fully immunized. This study identified one significant cluster of under immunization among children 12–23 months of age within the Butajira HDSS (relative risk (RR) = 1.24,P < 0·01). We found that children residing in this cluster had more than 1.24 times risk of under immunization compared with children residing outside of the identified cluster. We found significant differences with regard to Maternal Tetanus Toxoid immunization status and place of delivery between cases found within a spatial cluster and cases found outside the cluster. For example, the odds of home delivery is more than two times [AOR 2.21: 95%CI; 1.06, 4.63] among children within an identified spatial cluster than the odds among children found outside the identified cluster.

Conclusions

Under immunization of 12–23 months old children and under immunization with specific vaccines such as Polio, BCG, DPT (1–3) and Measles clustered geographically. Spatial studies could be effective in identifying geographic areas of under immunization for targeted intervention like in this study to gear health education to the specific locality.