bluuebunny/crossref_metadata_2025 huggingface dataset:
PENELITIAN DAN PENGEMBANGAN PADA MATA PELAJARAN BAHASA INDONESIA UNTUK MENINGKATKAN KEMAMPUAN MEMBACA PERMULAAN PESERTA DIDIK
Authors: Arief Hafid , Pamungkas Aan Subhan , Alamsyah Trian Pamungkas
Published: August 2023

Penelitian ini bertujuan unutk mengembangkan media pembelajaran video animasi untuk meningkatkan kemampuan membaca permulaan peserta didik di SDN Serang 21. Penelitian ini menggunakan jenis penelitian Research and Development (RnD) dengan menggunakan model ADDIE (Analysis, Design. Development, Implementation, Evaluation). Subjek penelitian ini adalah 22 peserta didik kelas I SDN Serang 21. Data dalam penelitian ini dikumpulkan melalui observasi, wawancara, angket, dan tes. Analisis data yang dilakukan adalah kuantitatif dan kualitatif. Hasil penelitian didapat nilai rata-rata validasi ahli dengan persentase 85,9% yang masuk dalam kategori “Sangat Layak”, nilai rata-rata respons peserta didik memperoleh persentase 95% yang masuk dalam kategori “Sangat Baik”, dan nilai rata-rata tes pemahaman peserta didik memperoleh nilai persentase 95% yang masuk dalam kategori “Sangat Baik”. Dengan demikian, dapat disimpulkan bahwa media pembelajaran video animasi ini dapat digunakan dalam pembelajaran dan layak dijadikan media pembelajaran untuk meningkatkan kemampuan membaca permulaan.
Food insecurity among students: why does it matter and how should universities address it?
Authors: Ravel Kanthan , Jayaram Rhea , Mulrooney Hilda Mary
Published: August 2023

Food insecurity (FI) is a major concern, particularly affecting those on low incomes, students included. FI may affect student attendance, engagement and sense of belonging to the university. A short survey about the cost-of-living crisis in a large London widening-participation university received 1090 student responses and these expressed high levels of concern. We contend that universities must help alleviate FI among their students. We accept that offering practical help to students may require significant continuing investment. Utilising existing community support within the context of a mutually beneficial relationship could reduce the burden on institutions and, in exchange, could offer in-kind support to the local community.
Motivações para a carreira gerencial: Um estudo com advogados da Procuradoria-Geral da Fazenda Nacional
Authors: Dalla Vecchia Rosangela , De Faveri Diego , Barbosa de Oliveira Lucia
Published: August 2023

Objetivo da pesquisa: Este estudo teve por objetivo investigar as motivações para a transição de carreira de uma posição técnica para uma função gerencial no contexto da administração pública brasileira. Mais especificamente, foram pesquisados advogados da Procuradoria-Geral da Fazenda Nacional (PGFN) e buscou-se identificar a importância relativa de diferentes fatores na decisão pela assunção de uma função gerencial na organização.

Enquadramento teórico: O trabalho tomou como aporte teórico a teoria motivacional da autodeterminação e a literatura sobre transição de carreiras, com foco na mobilidade vertical intraorganizacional.

Metodologia: Após a etapa qualitativa em que foi identificado um conjunto de sete motivadores – possibilidade de influenciar rumos e estratégias da organização, abertura para o desenvolvimento projetos novos e desafiadores, teletrabalho, clareza de atribuições, pessoal de apoio, capacitação e incentivo financeiro –, foram aplicadas técnicas de análise conjunta e de cluster junto a uma amostra de 515 advogados da PGFN.

Resultados: A análise conjunta, que permite identificar a importância relativa dos fatores, revelou que os mais importantes são a possibilidade de influenciar rumos e estratégias da organização e o teletrabalho. Já a análise de cluster apontou para três perfis de procuradores, denominados protagonistas, cautelosos e pragmáticos.

Originalidade: O trabalho faz uso das técnicas de análise conjunta e de cluster, relativamente pouco utilizadas em pesquisas sobre o tema.

Contribuições teóricas e práticas: Esta pesquisa contribui para as literaturas de gestão pública e transição de carreira, ao abordar os fatores que motivam servidores públicos na transição de uma função técnica para uma posição gerencial. De uma perspectiva aplicada, os resultados podem orientar o desenho de políticas que ampliem a atratividade de cargos de gestão no âmbito da administração pública brasileira, incluindo o estímulo à maior participação de mulheres nessas posições.

Palavras-chave: Burocrata de médio escalão; Transição de carreira; Carreira gerencial; Motivação; Teoria da autodeterminação.
Esfera Pública e Marco Regulatório das Organizações da Sociedade Civil no Brasil
Authors: Gonçalves Pereira Alexsander , Cabral Eloisa Helena de Souza , Alcântara Valderí de Castro
Published: August 2023

Objetivo da pesquisa: A estrutura argumentativa presente no processo de elaboração do Marco Regulatório das Organizações da Sociedade Civil, a Lei Federal nº 13.019 de 2014 é analisada ao longo dos últimos 22 anos.

Enquadramento teórico: A categoria “esfera pública” é mobilizada no âmbito da democracia deliberativa e da legitimidade das normas a partir de Jürgen Habermas e comentadores.

Metodologia: O estudo é teórico-empírico, do tipo exploratório e de natureza qualitativa. Os dados foram levantados por pesquisa documental nos meios: “Plataforma por um Novo MROSC”, projetos de leis, medidas provisórias, relatórios de comissões parlamentares, vídeos de audiências públicas, notícias de jornais e outros. Na análise foram formuladas categorias, a saber: valorização das organizações da sociedade civil; transparência na aplicação dos recursos públicos; segurança jurídica e efetividade nas parcerias.

Resultados: foram identificados os elementos da teoria da esfera pública habermasiana e do modelo de deliberação no caso das organizações e atores da sociedade civil. Registrou-se o debate em mídias contemporâneas, informais e formais, exclusivas ou especialmente construídas, como a “Plataforma por um Novo MROSC”, ou já estabelecidas como Youtube, Facebook, associadas a arenas como audiências públicas institucionais, seminários e reuniões.

Originalidade: O artigo inova ao descrever e compreender estrutura argumentativa presente no processo de elaboração do Marco Regulatório das Organizações da Sociedade Civil, a Lei Federal nº 13.019 de 2014 analisada, ao longo dos últimos 22 anos. Além disso, demostra que a democracia deliberativa é um instrumento de transformação social, protagonizado pela sociedade civil, em virtude da abertura de canais públicos de diálogo.

Contribuições teóricas e práticas: O exame das manifestações contribui para o entendimento de questões relevantes na aplicação da lei e aponta que a deliberação, valendo-se dos mecanismos de publicização, é, além de instrumento de mudança e comunicação da sociedade civil, um sugestivo campo de aprendizado para a implementação do MROSC.
20 Anos do Programa Nacional para a Prevenção e o Controle das Hepatites Virais: Processo Histórico e Contribuições para a Gestão
Authors: Souza Gleriano Josué , Dias Pedeschi Chaves Lucieli , Jackson da Conceição Pantoja Vencelau , Caminada Sirlene
Published: August 2023

Objetivo da Pesquisa: Organizar analiticamente aspectos históricos do Programa Nacional para a Prevenção e o Controle das Hepatites Virais (PNHV) acerca de estratégias de gestão para enfrentamento das hepatites virais no Sistema Único de Saúde (SUS).

Enquadramento Teórico: Referencial que subsidia a gestão de sistemas e serviços de saúde para ampliar possibilidades de análise em vista da legitimidade das ações propostas pelos agentes governamentais em relação ao PNHV.

Metodologia: Estudo de análise documental de contexto sociopolítico e histórico com recorte temporal, desde a criação do PNHV (2002-2021), embasado em documentos do escopo dos marcos legais. A análise permitiu agrupar os achados em duas seções: Implantação da política pública de atenção às hepatites e Estratégias para subsidiar a gestão no enfrentamento às hepatites virais.

Resultados: Constatam-se avanços, principalmente, na última década, quanto à extensão da vacinação à população, construção de diretrizes para apoiar a descentralização da atenção, com tentativas de organização de uma rede de atenção mais integrada. Há premência de ampliar o diálogo sobre a condução da gestão para fortalecer diretrizes que articule uma rede de atenção à saúde respeitando os princípios do SUS.

Originalidade: Apresenta-se produção que sumariza importantes marcos legais e possibilita refletir sobre a gestão do SUS no enfrentamento das hepatites, mas também apresenta estratégias à gestão para potencializar o PNHV.

Contribuições Teóricas e Práticas: Marca um contexto político de atuação do PNHV e sumariza considerações que podem contribuir para ampliar a capilaridade de serviços de saúde na rede de atenção, analisar o modelo de organização, além de pontuar a necessidade de investimento no quantitativo profissional qualificado, ou seja, aspectos que requererão forte atuação da gestão para alcance das metas pactuadas na agenda 2030.
Determinantes dos Gastos Públicos em Gestão Ambiental nos Municípios da Região Sul do Brasil no Período de 2002 a 2019
Authors: Broietti Cleber
Published: August 2023

- Objetivo da pesquisa: analisar os determinantes dos gastos públicos em gestão ambiental nos municípios do Sul do Brasil no período de 2002 a 2019.

- Enquadramento teórico: Os referenciais teóricos utilizados foram os de políticas públicas e o de gastos públicos ambientais.

- Metodologia: Os dados dos gastos ambientais foram coletados da Secretária do Tesouro Nacional (STN), realizou-se a análise descritiva dos dados e para a análise das variáveis, utilizou-se o modelo econométrico de dados em painel, servindo-se do software Stata®.

- Resultados: As análises apontaram que as variáveis, Receita Recebida e Despesa Total foram as que apresentaram resultados significantes, isto implica que, quanto maior a receita recebida e quanto maior as despesas totais, maior será o gasto ambiental. Destaca-se o estado do Paraná que apresentou o maior gasto ambiental relativo entre os estados do Sul do Brasil.

- Originalidade: O estudo contribui para suprir a lacuna sobre os determinantes do gastos públicos ambientais dos municípios da Região Sul do Brasil, por se trarar de uma importante região do país, com características próprias, destacando-se em atividades industriais e agropecuária, cuja essas atividades são causadoras de impactos ambientais.

- Contribuições téoricas e práticas: contribuir com os estudos sobre os gastos ambientais dos municípios brasileiros, que ainda são muito reduzidos  e também contribui para a área ambiental no sentido de acompanhamento das ações e impactos dos gastos ambientais na gestão pública ambiental.
A Ação Empreendedora no Setor Público: Uma Análise da Interação Família-Escola em Instituições Educacionais Públicas
Authors: Silva Camila de Assis , Meirelles Andrade Daniela , Braga de Lima Juvêncio
Published: August 2023

Objetivo de pesquisa: Analisar a pesquisa sobre a prática da Interação Família-Escola, como uma ação pública desenvolvida em instituições educacionais de um município do Sul de Minas Gerais.

Enquadramento teórico: O artigo apresenta a ação empreendedora no setor público, a gestão escolar e o Plano Nacional de Educação, com o propósito de compreender as relações destes conceitos.

Metodologia: O artigo utilizou a abordagem qualitativa, explicativa, por meio do estudo de casos múltiplos. Assim, o estudo foi amparado pela triangulação de dados, com complementação de análises documentais e análise de conteúdo das entrevistas com os gestores da secretaria de educação, grupo focal com os gestores de um CMEI e, grupo focal com os responsáveis pelos alunos de uma escola que participa do projeto.

Resultados: O projeto Interação Família-Escola, consiste em uma ação empreendedora pública, reconhecendo-se que os gestores da SEDUC em consonância com outras secretarias municipais agiram segundo os critérios e práticas que a configuram, com resultados positivos.

Originalidade: Os resultados contribuem para a literatura brasileira, ao relacionar a ação empreendedora pública e a gestão escolar, com o intuito de suprir a carência dessas temáticas de trabalhos em diversas áreas de estudo.

Contribuições teóricas e práticas: Espera-se favorecer o entendimento de como esse projeto funciona na prática, por meio das suas contribuições e desafios para a vida dos professores, alunos, família e sociedade. Uma outra contribuição é para os estudos relacionados às ações empreendedoras no setor público brasileiro, principalmente ao se tratar do contexto educacional, pois ainda há uma carência de trabalhos relacionados à essa temática. Ademais, tem-se uma contribuição para o campo da gestão social, uma vez que a ação empreendedora pública possui aproximação com muitos preceitos da gestão social.
A Two-stage Optimization Replacement Policy with Multiple Spare Units
Authors: Zhang Chunxiao , Shen Hejiao , Bai Yizhou
Published: August 2023

This paper presents a two-stage optimization replacement policy considering reliability and economy for a system with N multiple spare units. We assume that the failure time of each unit is stochastic, and the operating system is replaced at failure or at planned replacement time interval Tk (k=1,2,...,N) from its installation, which ever occurs first. In stage 1, we maximizes mean time to failure (MTTF) to obtain the optimum replacement time intervals [[EQUATION]]. In stage 2, the aim is to find the optimum number of spare units N* which minimizes expected cost rate, and the existence condition of unique optimum solution is given. Finally, numerical examples and sensitivity analysis are carried out to demonstrate the presented policy.
Practical exploration of BOPPPS model combined with situational teaching method in clinical training of intensive medicine
Authors: Liu Yanquan , Zeng Minjuan , Yin Yue , Hong Xiaomei , Wang Shimei , Tang Huanwen
Published: August 2023

Background:
To explore the application value of BOPPPS model combined with situational teaching method in the clinical teaching of intensive care unit (ICU), and to provide experience for the reform of ICU clinical teaching and standardized training of intensive medicine specialists.
Methods:
A total of 293 residents in ICU of the Affiliated Hospital of Guangdong Medical University, Fujian Medical University Union Hospital and the Xiamen Medical College from January 2018 to September 2022 were selected as subjects, and randomly divided into control group (142) and experimental group (151). The control group adopted bedside teaching and demonstration teaching method, and the experimental group adopted BOPPPS model combined with situational teaching method. Clinical teaching performance was evaluated by ICU admission examination, and study process questionnaire (SPQ) and the critical thinking disposition inventory-Chinese version (CTDI-CV) was used to evaluate the learning motivation and critical thinking ability of the two groups. At the same time, the ICU rotation training Effect Evaluation and Satisfaction Questionnaire was used to evaluate the teaching satisfaction. In this study, SPSS 21.0 software was used to conduct t test and Chi-square test.
Results:
The scores of the test group in ICU theoretical knowledge, clinical thinking and skills, and the treatment of clinical critical cases were higher than those of the control group [(87.31±2.15), (92.86±2.35), (83.45±3.28)] vs. [(81.94±2.73), (84.37±2.61), (78.83±3.47)], the difference between the two groups was statistically significant (P<0.05). The scores of surface motivation, deep motivation, achievement motivation and SPQ total scores of the experimental group were all higher than those in control group (P<0.05), and the scores of seek truth, open mind, analytical ability, systematic ability, self-confidence of critical thinking and intellectual curiosity of the experimental group were also higher than those in the control group, and the CTDI total score was statistically significant (P<0.05). In addition, the results of the questionnaire showed that the experimental group was better than the control group in terms of learning interest in ICU, improvement of humanistic care and doctor-patient communication ability, improvement of teamwork ability, improvement of job identity, ICU rotation harvest and satisfaction with teacher style (P<0.05).
Conclusion:
The combination of BOPPPS model and situational teaching method is novel and helpful to improve the clinical comprehensive ability of ICU residents and improve the training quality of young doctors, which is worth learning and promoting.
Integration of Single-Cell Sequencing and Transcriptomic Analysis to Identify Novel Diagnostic Biomarkers for Preeclampsia and Explore Changes in Immune Cell Interactions
Authors: Huang Zhengrui , Wei Jiachun , sun Lu , Shi Meiting , He Andong , Wang Xiufang , Wang Jian , Zhang Ping , Li Qing , Li Ruiman
Published: August 2023

Background
Preeclampsia is a severe complication of pregnancy that can impose a significant economic burden and pose a serious threat to the health of both mothers and infants. Currently, there are no effective treatment methods for established preeclampsia other than delivering the placenta.
Methods
We performed differential analysis and weighted correlation network analysis (WGCNA) on RNA-seq datasets to identify highly associated blood system biomarkers in preeclampsia. The expression levels and potential predictive value of these biomarkers were validated through ELISA experiments. Subsequently, multiple bioinformatics analyses were conducted to predict the biological activities and gene mappings of the selected genes. The changes in the proportions of blood immune cells and abnormal cell-cell communication in the pathogenesis of preeclampsia were explored through analysis of single-cell transcriptomics data from blood samples. Potential candidate drugs were predicted using the DrugBank database.
Results
We identified and preliminarily validated the expression levels of F2R Like Trypsin Receptor 1 (F2RL1) and Granzyme H (GZMH) in maternal blood samples from preeclampsia through quantitative experiments. Gene Set Enrichment Analysis (GSEA) indicated that F2RL1 is involved in the regulation of classical signaling pathways, including Toll-like receptor signaling pathway, pattern recognition receptor signaling pathway, oxidative stress-induced intrinsic apoptotic signaling pathway, and vesicle targeting processes. GZMH is primarily involved in immune processes associated with natural killer cells and also regulates lymphocyte chemotaxis. Analysis of single-cell sequencing datasets revealed significant changes in T cells and hematopoietic Stem Cell Growth Factor (HSC G-CSF) in the maternal blood system during the pathogenesis of preeclampsia. Receptor-ligand analysis and protein-drug analysis highlighted the important role of aspirin in the treatment of preeclampsia, as well as the potential value of tyrosine kinase inhibitors in preeclampsia treatment.
Conclusion:
This study identified the preeclampsia biomarkers F2RL1 and GZMH, which showed good diagnostic value, and predicted their potential biological functions. The disrupted immune environment in the maternal blood system and potential therapeutic drugs were explored through single-cell transcriptomics data analysis. This research provides new insights for the prediction of preeclampsia and deepens our understanding of the changes in the maternal blood system's immune environment during preeclampsia. However, further laboratory work and multicenter clinical evidence are still needed to clarify the clinical prospects of these findings.
Her Period, Our Taboo: The attitudes and perceptions of schoolboys towards menstruation in Ghana: a cross-sectional study
Authors: Oklu Perpetual , Charles-Unadike Veronica Okwuchi , Salu Samuel , Ananga Mark Kwame
Published: August 2023

Background
Menstrual hygiene plays an important role in the health of young women. It is a hygienic practice during menstruation such as adequate cleaning of the external genitalia, use of a sanitary pad, and frequently changing the pad every 3–4 hours to prevent odour. The role of the male counterparts in reproductive health has been acknowledged as an important contributor to menstrual hygiene. However, most of them do not know about the normal physiology of menstruation. This study aimed at assessing the perception and attitude of schoolboys towards menstruation in the Hohoe Municipality, Ghana.
Methods
This was a descriptive cross-sectional study conducted within the period from March to July 2021. A total of 273 schoolboys participated in the study with a 100% response rate. Data collected were entered into Epi Data Entry Client version 4.6.0.2 and then exported into the STATA V.16.0 (StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX: StataCorp LLC.) for analysis.
Results
The findings from this study revealed that the majority 166 (60.8%) of the schoolboys had a poor perception of menstruation as compared to their counterparts. The study also found that a higher proportion of the schoolboys 145 (53.1%) had poor attitudes towards menstruation.
Conclusion
The study results highlight the urgent need for interventions aimed at addressing the knowledge gap and fostering positive attitudes among schoolboys towards menstruation.
A trend analysis of tuberculosis mortality among rural people in China from 2006 to 2020: a joinpoint and age-period-cohort analysis
Authors: ni shuaihu , Sun Ke , Luo Xiaofeng , Qu Yan
Published: August 2023

Objective
To investigate the mortality trends of tuberculosis among rural people in China from 2006 to 2020, and to provide a basis for formulating scientific tuberculosis prevention and control strategies.
Methods
According to the data of Chinese Disease Surveillance Points, taking rural people aged 5 ~ 84 years in China from 2006 to 2020 as the research subjects, the Joinpoint regression model was used to explore the overall trend of tuberculosis mortality, and the age-period-cohort model was used to estimate the age effect, period effect and birth cohort effect.
Results
From 2006 to 2020, the standardized mortality rate of tuberculosis among rural people in China showed a downward trend. The age effect of tuberculosis deaths in the population was on the rise, with the age of men aged 35 ~ 84 and women aged 60 ~ 84 as risk factors; The period effect showed a downward trend, the rate of decline gradually slowed down, and the risk of death in males increased from 2016 to 2020; The birth cohort effect generally declined, and birth cohorts turned into protective factors after 1969 ~ 1973. Males had an increased risk of death in the birth cohorts 1964 ~ 1968, 1984 ~ 1988, 1994 ~ 1998, and 2004 ~ 2008. Females also had an increased risk of death in the birth cohort 1989 ~ 2003.
Conclusions
Rural males aged 35 ~ 84 years old and females aged 60 ~ 84 years old had a higher risk of tuberculosis death. The risk of TB death for rural people decreased overall over time, with the risk of TB death increasing for rural males from 2016 to 2020. In general, the risk of TB death is lower in late birth cohorts, However, it is alarming that the risk of TB death increased in some birth cohorts in recent years, both males and females.
Seismic hazard evaluation of Nepal region: a particular emphasis on 2015 Gorkha earthquake scenario
Authors: Saini Atul , Mohanty Debasis D , Mittal Himanshu
Published: August 2023

The tectonic collision between the Indian and Eurasian plates since 50 million years is responsible for creating the Nepal Himalayan zone as part of the whole Himalayan orogeny belt. As a result of this collision, major changes and deformation in Earth have been evolving through ongoing stress build-up and release. In this study, an overview of the stress distribution has been made by using the Frequency-magnitude relation across the Nepal Himalayan region, which is supported by an extensive analysis of b-values and their spatiotemporal variations. Abruptly the whole region is being divided into four sub-regions. The consequences of b-value changes have been thoroughly examined for a better and minute analysis of the present-day hazardous scenario of this Nepal Himalayan region. Two highly stressed areas have been observed in Nepal's eastern and westernmost parts by interpreting the b-values. The depth sections of the b-value are estimated across the two zones revealing that these stress-accumulated regions are increasing in depth with an increase in latitude towards the north. A moderately stressed area was also found, which is concentrated mainly around the MCT fault in the western part. A particular emphasis on the 2015 Gorkha region has been carried out to analyze this region's pre- and post-earthquake scenarios and stress patterns. The analysis revealed that most of the stress released by the Gorkha earthquake was concentrated in the western side of the event, whereas the eastern side was still moderately stressed.
Towards Genomic Medicine: A Tailored Next-Generation Sequencing Panel for Hydroxyurea Pharmacogenomics in Tanzania
Authors: Nkya Siana , Nzunda Collin , Saukiwa Emmanuel , Kaywanga Frida , Buchard Eliud , Solomon David , Christopher Heavenlight , Ngowi Doreen , Johansen Julieth , Urio Florence , Mgaya Josephine , Karim Salman , Alimohamed Mohamed Zahir , Sangeda Raphael Z. , Chamba Clara , Chimusa Emile R. , Novelli Enrico , Makani Julie
Published: August 2023

Pharmacogenomics of hydroxyurea is an important aspect in the management of sickle cell disease (SCD), especially in the era of genomic medicine. Genetic variations in loci associated with HbF induction and drug metabolism are prime targets for hydroxyurea (HU) pharmacogenomics. This study investigated genetic variations in BCL11A, ARG2, HBB, HBG1, WAC, HBG2, HAO2, MYB, SAR1A, KLF10, CYP2C9, CYP2E1 and NOS1 as potential HU pharmacogenomics targets. The panel was designed using the Illumina Design Studio (Illumina, San Diego, CA, USA) and achieved a total coverage of 96% of all genomic targets over a span of 51.6 kilobases (kb). We are reporting a successfully designed Illumina (MiSeq) HU pharmacogenomics custom panel encompassing 51.6 kilobases. The designed panel achieved greater than 1000x amplicon coverage which is which is sufficient for genomic analysis. Therefore, this study provides a valuable tool for research in HU pharmacogenomics, especially in Africa.
Morpho-Histopathological Assessment of Platelet-Rich Fibrin, Stem Cell-Derived Micro vesicles, and ZnO Nanoparticles on Achilles Tendon Healing in Rabbits
Authors: Hassan Mahmoud A. , Elgohary Islam , Abdallah Ahmed F. , Nassif Mahmoud T. , El-Sherif Mohamed W.
Published: August 2023

The objective of this study was to evaluate the effect of zinc oxide nanoparticles (ZnONP), mesenchymal stem cell-derived micro vesicles (MVs), and Advanced platelet-rich fibrin (A-PRF) on the healing of Achilles tendon defects in rabbits during the inflammatory, proliferative, and remodeling phases through histological examination and quantitative assessments. Twenty-four adult male New Zealand albino rabbits with Achilles tendon defects were divided into four equal groups of six animals each. In the control group, the Achilles tendon defect was left untreated. In the ZnONP group, the defect was injected with 0.5 ml of 0.2% ZnONP. In the MVs group, MSC-derived MVs were injected into the defect twice within one week apart. In the A-PRF group, the defect was filled with a PRF membrane. Tendon tissue was harvested at 2, 4, and 6 weeks after treatment and sections were stained with hematoxylin-eosin and Masson trichrome. Histological examination revealed that proliferation and remodeling of collagen fibers and approximation of normal tendinous tissue occurred earlier in the ZnONP group after 6 weeks than in other treated groups. This study demonstrated that ZnONP have a significant ability to enhance and accelerate the healing and regeneration processes of the Achilles tendon.
Evaluation of Endometrial Receptivity in Patients with Recurrent Pregnancy Loss and Recurrent Implantation Failure
Authors: Canan Sultan , İnan Mehmet Arda , Erdem Ahmet , Demirdağ Erhan , Gündüz Mualla İlknur , Erdem Özlem , Erdem Mehmet
Published: August 2023

Background: The cause of implantation defects in patients with recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) has not been clearly established. We aimed to evaluate the immunohistochemical changes of HOXA-11, β1 integrin, Focal Adhesion Kinase (FAK), CD44, and Extracellular Matrix Protein 1 (ECM1) in the endometrium of patients with defective implantation -RIF and RPL- in the receptive period.
Methods: This retrospective case-control study was conducted in a university hospital. After the exclusion of all cases with pathology that may cause a change in the level of receptors in the endometrium, biopsies taken during the receptive period were selected, and the patients were divided into RPL (n=15), RIF (n=16), and control (n=16) groups. All preparations were immunohistochemically stained for HOXA11, β1 integrin, FAK, CD44, and ECM1. The presence or absence of staining and staining intensity were compared between groups.
Results: When the RIF group was compared with the control group, there was no significant difference in HOXA-11 and β1 Integrin expression (p>0.05), FAK expression was significantly increased compared to the control group (p<0.01); ECM1 and CD44 expressions were found to be significantly decreased (p<0.01). When the RPL group was compared with the control group, there was no significant difference in the endometrial staining of HOXA-11, FAK, and ECM1 in women with a history of RPL (p>0.05); β1 Integrin and CD44 levels were significantly decreased (p<0.05).
Conclusion: CD44 reduction may play a role in pathophysiology in both patient groups. In addition, decreased β1 integrin may also play a role in RPL. In RIF, the increase in FAK and decrease in ECM1 seem to be involved in the mechanisms of the disease.
5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis
Authors: zhang Lei , Han Xiaotong , Chen Hangyu , Shang Chunliang , Chen Long , Lin Jian , Guo Hongyan
Published: August 2023

Background:
At present, clinical diagnosis and classification of adenomyosis are mainly dependent on MRI or pathological examination, and little research is carried out on molecular biomarkers for the diagnosis and classification of adenomyosis. Our aim is to identify molecular biomarkers for the diagnosis and classification of adenomyosis.
Methods:
5hmC-Seal technique was used to obtain genome-wide 5hmC profiles from plasma cfDNA and tissue genomic DNA samples. Patients were divided into the training (n = 26) and the validation group (n = 25), and a 5hmC-based Logistic regression model from the training group was developed to verify the diagnostic capability of the model. Meanwhile, we investigated whether 5hmC molecular markers could be used to classify the two main subtypes of adenomyosis.
Results:
In this study, ten 5hmC markers were identified by using machine learning techniques. The diagnostic ability reached 0.88 sensitivity and 0.87 specificity (AUC = 0.91). Next, we found that 5hmC markers can be used as markers for adenomyosis classification.
Conclusions:
Our results showed that 5hmC markers of cfDNA had the potential to be used for diagnosis and classification in adenomyosis patients, and 5hmC-Seal may be a clinically applicable and minimally invasive method for the diagnosis and classification of adenomyosis in the future.
Development and validation of a multi-modal ultrasomics model to predict response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
Authors: Qin Qiong , Gan Xiangyu , Lin Peng , Pang Jingshu , Gao Ruizhi , Wen Rong , Liu Dun , Tang Quanquan , Liu Changwen , He Yun , Yang Hong , Wu Yuquan
Published: August 2023

Objectives
To assess the performance of multi-modal ultrasomics model to predict efficacy to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC) and compare with the clinical model.
Materials and methods
This study retrospectively included 106 patients with LARC who underwent total mesorectal excision after nCRT between April 2018 and April 2023 at our hospital, randomly divided into a training set of 74 and a validation set of 32 in a 7: 3 ratios. Ultrasomics features were extracted from the tumors’ region of interest of B-mode ultrasound (BUS) and contrast-enhanced ultrasound (CEUS) images based on PyRadiomics. Mann-Whitney U test, spearman, and least absolute shrinkage and selection operator algorithms were utilized to reduce features dimension. Five models were built with ultrasomics and clinical analysis using multilayer perceptron neural network classifier based on python. Including BUS, CEUS, Combined_1, Combined_2 and Clinical models. The diagnostic performance of models was assessed with the area under the curve (AUC) of the receiver operating characteristic. The DeLong testing algorithm was utilized to compare the models’ overall performance.
Results
The AUC (95% confidence interval [CI]) of the five models in the validation cohort were as follows: BUS 0.675 (95%CI: 0.481–0.868), CEUS 0.821 (95%CI: 0.660–0.983), Combined_1 0.829 (95%CI: 0.673–0.985), Combined_2 0.893 (95%CI: 0.780-1.000), and Clinical 0.690 (95%CI: 0.509–0.872). The Combined_2 model was the best in the overall prediction performance, showed significantly better compared to the Clinical model after DeLong testing (P < 0.01). Both univariate and multivariate logistic regression analyses showed that age (P < 0.01) and clinical stage (P < 0.01) could be an independent predictor of efficacy after nCRT in patients with LARC.
Conclusion
The ultrasomics model had better diagnostic performance to predict efficacy to nCRT in patients with LARC than the Clinical model.
WITHDRAWN: Review From Beneficial Arthropods to Soil-Dwelling Organisms: A Review on Millipedes in Africa
Authors: Mawcha Kahsay Tadesse
Published: August 2023

Millipedes are important soil-dwelling organisms that play a vital role in the soil's nutrient cycling and overall health. They can increase the availability of nitrogen and phosphorus and accelerate the decomposition of organic matter in the soil. However, they can also cause significant damage to crop plants, which can lead to reduced yields and negatively impact both soil quality and plant health. Integrated Pest Management (IPM) strategies may be necessary to effectively manage millipedes. These strategies involve a combination of cultural and chemical control methods that are tailored to specific crops and environmental conditions. By taking a holistic, ecosystem-based approach, IPM strategies can effectively manage millipede populations while minimizing negative impacts on the environment. Monitoring millipede activity and implementing control measures in areas with a high infestation is a crucial measure. This review provides recent research progress on millipede’s biology, ecology, and agriculture pest status of millipedes in Africa and beyond and IPM strategies to control their infestation in agricultural crops.
Functional analysis of the wheat class III peroxidase gene TaPer12-3A in seed dormancy and germination
Authors: Gao Wei , Jiang Yating , Yang Xiaohu , Li Ting , Zhang Litian , Yan Shengnan , Cao Jiajia , Lu Jie , Ma Chuanxi , Chang Cheng , Zhang Haiping
Published: August 2023

Class III peroxidases (PODs) perform crucial functions in various developmental processes and in response to biotic and abiotic stresses. However, the specific roles of class III POD genes in wheat seed dormancy (SD) and germination remain elusive. Here, we identified a wheat class III POD gene, named TaPer12-3A, based on transcriptome data and expression analysis. TaPer12-3A showed decreasing and increasing expression trends with SD acquisition and release, respectively, indicating a significant association with SD and germination. It was highly expressed in wheat seeds and localized in the endoplasmic reticulum and cytoplasm. Germination tests indicated that TaPer12-3A negatively regulated SD and positively mediated germination in transgenic Arabidopsis and rice lines as well as in a wheat mutant mutagenized with ethyl methane sulfonate (EMS) in Jing 411 background. Further studies demonstrated that TaPer12-3A regulated SD and germination by interacting with gibberellin and abscisic acid biosynthesis, catabolism, and signaling pathways in transgenic rice seeds. These findings not only provide new insights for future functional analysis of TaPer12-3A in regulating wheat SD and germination but also contribute to understanding the complex regulatory mechanism involved in these processes.
Influence of digitalisation on business success in Austrian Traded Prime Market Companies – a longitudinal study
Authors: Hangl Christa
Published: August 2023

The paper examines whether software investments have an impact on the economic success of the companies listed on the Austrian Traded (ATX) Prime market.
A literature review and qualitative content analysis are performed to answer the research questions. For testing hypotheses, a longitudinal study is conducted. Over a ten-year period, the consolidated financial statements of the businesses under review are evaluated. A panel will assist with the data analysis. This study offers notable distinctions from other research that has investigated the correlation between digitalisation and economic success. The present research employs a methodology that involves quantifying the extent of digitalisation by conducting a thorough investigation of the group annual reports of the companies in the study.
The regression analysis of all businesses revealed no correlation between software expenditures and economic success. The qualitative content analysis demonstrated that organisations belonging to the finance sector are particularly engaged in numerous digitalisation efforts. Consequently, separate regression models were computed for finance and non-finance companies. The correlation between software investments and economic success in both industries is evident.
JEL codes: O33, E22, G21
Navigating between promises and realities of transdisciplinarity for environmental conservation
Authors: Rosa Gabriela De La , Muñiz Esther Milberg , El-Hani Charbel N. , Ludwig David
Published: August 2023

Conservation approaches focused solely on technical aspects have proven insufficient in addressing the complexity of the current socioenvironmental crisis. Transdisciplinarity has emerged as a promising approach to combining technical perspectives with qualitative insights from the social sciences and non-academic stakeholders. However, transdisciplinary incorporation of diverse interests, knowledge, and worldviews requires acknowledging and addressing inherent inequities. This article presents a case study that applies transdisciplinary principles through two layers of reflection. The first layer involves a biologist/ecologist working in a transdisciplinary group, applying a quick participatory diagnosis, while the second layer comprises a social scientist studying the group itself. By analyzing the results obtained from these reflective layers, the article aims to explore the challenges and possibilities of navigating from transdisciplinary ideals to practical implementation. The findings highlight the importance of nurturing relationships built on care, reciprocity, and openness to address the power imbalances inherent in university-community participatory practices. Through this perspective, the article suggests that the community's autonomy and agency can be preserved while actively engaging its members in the transdisciplinary process. These suggestions contribute to alleviating power differences and fostering a collaborative and equitable transdisciplinary framework. Overall, this study emphasizes the significance of integrating participatory methods, critical reflexivity, and attention to power dynamics in realizing the potential of transdisciplinary approaches for addressing complex conservation challenges and fostering meaningful community engagement.
Trustworthy Healthcare Cloud Storage Auditing Scheme (TCSHAS) with Blockchain-based Incentive Mechanism
Authors: Bose Rajesh , Sutradhar Sharabani , Bhattacharyya Debnath , Roy Sandip
Published: August 2023

In this paper, we present the Trustworthy Healthcare Cloud Storage Auditing Scheme (TCSHAS) to address the trust issues associated with third-party auditors (TPAs) in traditional healthcare cloud storage audit schemes. Leveraging the non-tamperability and traceability features of blockchain technology, we propose a novel incentive mechanism that promotes honest and reliable behaviors among TPAs. Our approach involves organizing TPAs as a group of blockchain nodes that engage in mutual surveillance, ensuring the maintenance of a reputable group by inspecting and punishing malicious behaviors severely. We provide a comprehensive system model for the TCSHAS, which incorporates smart contracts to handle transactions-related matters, including dispute resolution. Through performance evaluations, we demonstrate that our scheme offers acceptable efficiency and is well-suited for real-world healthcare applications. By utilizing blockchain technology and a robust incentive mechanism, the TCSHAS enhances trust and security in healthcare cloud storage auditing, providing a foundation for reliable and accountable management of sensitive healthcare data.
Exploring the Mechanism and discovery of potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
Authors: Ullah Numan , Shahab Muhammad , Yaseen Muhammad , Bhat Mashooq Ahmad , Gul Mian , Zheng Guojun , Akter Shahina
Published: August 2023

The rise of antibiotic-resistant Mycobacterium tuberculosis (MTB) has led to a reduction in the availability of effective medications for tuberculosis therapy, resulting in increased morbidity and mortality globally. Tuberculosis primarily affects the lungs but can also spread to the brain and spine. Pyrazinamide (PZA) is considered to be the most potent drug but it also shows resistance due to mutation at the position G97D. However, the Mechanism of PZA drug resistance towards Mtb PZase is unclear. Moreover, due to mutations that provide PZA resistance, there is no such evidence about the structural dynamics of Mtb PZase protein. Here we aimed to perform molecular docking, pharmacophore modeling, virtual Screening, and MD simulation, to explore the Mtb PZase protein resistance mechanism toward the PZA drug due to mutation at the G97D position as well as compare the Wild-type and Mutant-type PZA bound systems. From the analysis, the Wild-type shows good interaction as compared to Mutant-type PZA bound systems. Then we performed pharmacophore-based virtual screening against commercially available databases i.e. ZINC and Chembridge. Finally, we selected a total of 5 lead compounds based on docking score and good interaction. The selected compounds considered has a good ADMET property, because the compound shows no pan Assay interference (PAINS) indicating that these compound could be useful inhibitors of Mutant-type PZA bound systems.
A system dynamics-based model for the evolution of environmental group events
Authors: Qi Xue-ting , Bu Fanliang
Published: August 2023

Based on the system dynamics theory, this paper establishes an environmental mass event evolution model and explores the evolution law of mass events caused by environmental problems. From a methodological point of view, the mixed-strategy evolutionary game principle and dynamic punishment measures are combined, and simulation analysis is carried out by Anylogic software, and the results show that there is no stable evolutionary equilibrium solution for the two sides of the game in the traditional asymmetric mixed-strategy game model, and after adjusting the game payoff matrix and incorporating the dynamic punishment strategy, stable evolutionary equilibrium solutions appear in the evolutionary game model, and the system begins to tend to be stabilized. The process and conclusions of the simulation experiment provide methodological reference and theoretical support for the analysis of the evolution of environmental mass events.
A Compact Metamaterial Loaded MIMO Antenna for Sub-6GHz 5G Applications
Authors: V Arulkumar , P Jeyakumar , P Rajalakshmi , S Subash , V Pradeep , S Vishwa , P Muthuchidambaranathan P
Published: August 2023

In this work, the proposed design utilizes a complementary split ring resonator (CSRR) loaded ground plane to enhance the return loss of a microstrip patch antenna.The addition of CSRR slots on the ground plane resulted in an improvement in the return loss of the microstrip patch antenna. The proposed antenna has undergone the stages of design, fabrication, and testing. The measured results exhibit a high level of conformity with the simulation results. The proposed antenna has a size of 99 × 55 × 1.6mm 3. The measured impedance 1 Springer Nature 2021 L A T E X template A Compact Metamaterial Loaded MIMO Antenna for Sub-6GHz 5G Applications bandwidth is 24.18 (return loss< −10 db) from 3.29 to 4.2 GHz. The designed antenna is suitable for applications within the Industrial Scientific Medical(ISM) band. The H-plane radiation pattern of the antenna was directional, while the E-plane radiation pattern was bidirectional. To achieve optimal outcomes, a parametric investigation of the CSRR was conducted. Alternatively, researchers carried out a study on various parameters of the CSRR to determine the most favorable results. The proposed antenna exhibits a straightforward design, displays a desirable radiation pattern, and boasts a gain of 2.63 dBi when operating at its resonant frequency. Additionally, a size reduction of 10% was attained without compromising its performance, and the bandwidth slightly surpasses that of the unloaded antenna.
Spatio – Temporal Study of Crop Combinations and Land Use Pattern of Karnal District
Authors: Yadav Mandeep , sharma Sukriti
Published: August 2023

This paper attempts to examine the change in cropping pattern and crop combination in Karnal District of Haryana. The change in cropping pattern in the study area examined to understand the share of various crops in the study area during a particular period of time 2010–11 to 2019–20. Haryana is a state with a thriving agriculture sector. Wheat and rice are the two main crops grown in Haryana, and they are followed in importance by sugarcane, gram, barley, cotton, oil seeds, bajra, jawar, etc. (Kumar, 2017). A particular crop rarely occupies a position in complete isolation from other crops in a given area at a given time since crops are typically cultivated in combinations. The extent of the crop lands is determined by socio-economic interactions, while their shape is determined by physical variables. In particular, the study of comprehensive area development planning benefits from the research of crop combinations (Murugesan et al., 2018). Considering that it provides a solid foundation for agricultural regionalization, the study of crop combination and crop intensity is a crucial component of agricultural geography. Geographers and agricultural land-use planners have recently become interested in the definition of crop combinations.