bluuebunny/crossref_metadata_2025 huggingface dataset:
Litter removal impacts on soil biodiversity and eucalypt plantation development in the seasonal tropics
Authors: Inkotte Jonas , Bomfim Barbara , da Silva Sarah Camelo , Valadão Marco Bruno Xavier , da Rosa Márcio Gonçalves , Viana Roberta Batista , Gatto Alcides , Pereira Reginaldo S.
Published: September 2022

The little layer of tree plantations provides primary nutrients for uptake, buffers changes in soil moisture, and provides habitat and substrate to soil epigeic fauna. However, this layer in eucalypt plantations is often removed to reduce fuel load during the fire season in the Brazilian savanna (Cerrado). Therefore, it is necessary to quantify the effects of changes in litter dynamics on the function of these plantations, on key nutrient cycling processes and on epigeic fauna diversity and abundance. In two adjacent stands (one juvenile and one mature), the consequences of two years of litter removal were quantified as monthly litterfall, leaf and fine wood litter decomposition, epigeic fauna abundance and diversity, soil biogeochemical variables, and tree diameter and basal area increments. Monthly litterfall rates in juvenile and mature stands did not change with litter removal over the study period. Annual litterfall ranged from 4.1 to 4.9 Mg ha−1a−1 in litter removal plots and from 3.9 to 4.8 Mg ha−1a−1 in control plots. Fine wood litter decomposition was slower in litter removal plots compared to controls, while leaf decomposition rates were similar in both. Two years of litter removal in the juvenile stand did not affect topsoil biogeochemical parameters but decreased available phosphorus at 20–40 cm depth relative to controls. In the mature stand, total cation exchange capacity (0–20 cm) was higher in controls (6.4 cmolc dm−3) relative to litter removal plots (6.3 cmolc dm−3), while soil moisture (0–40 cm depth) was lower in litter removal (25.45 m3 m−3) compared to control plots (26 m3 m−3) in the dry season. A non-metric multidimensional scaling ordination revealed an increased homogeneity in epigeic fauna where litter was removed. Litterfall, decomposition, diameter increment, four soil physical parameters and fourteen chemical parameters at 0–20 and 20–40 cm depth explained the differences in soil epigeic fauna composition between litter removal and control plots. Diameter increment decreased with litter removal only in the juvenile stand, which had reached its growth peak. The results indicate that removing excess litter to decrease fuel volume can alter soil biodiversity and edaphic conditions that negatively affect nutrient cycling and tree growth.
Alterations in Gut Microbiota Profiles of Mice Infected with Echinococcus granulosus sensu lato Microbiota Profiles of Mice Infected with E. granulosus s.l.
Authors: Zhu Mingxing , Wang Chan , Yang Songhao , Du Xiancai , Zhu Yazhou , Zhang Tingrui , Lv Yongxue , Zhao Wei
Published: September 2022

Objective

Cystic echinococcosis is a kind of parasitic disease that seriously endangers human and animal health. At present, its prevention and treatment still do not achieve the desired results. The aims of this study were to explore the effect of CE on intestinal microflora in mice.

Methods

In this study, 16S rRNA metagenome sequencing and bioinformatics were used to analyze the intestinal flora of mice infected with E. granulosus s.l. Changes in intestinal microbial community abundance were investigated and the differences in microbial populations of mice infected with E. granulosus s.l. were screened.

Results

Our results show that at the phylum level, nine abundant taxa were identified, the relative abundance of Firmicutes and Proteobacteria were enriched in infected mice, whereas Bacteroidetes and Patescibacteria were enriched in control mice (P < 0.01). At the class level, 13 abundant taxa were identified, the relative abundance of Bacilli was enriched in control mice, but decreased in infected mice (P < 0.01). At the order level, 15 abundant taxa were identified, the relative abundance of Lactobacillales was enriched in control mice, but decreased in infected mice (P < 0.01). At the family level, 28 abundant taxa were identified, enriched bacteria in the infected mice was Streptococcaceae, while the enriched bacteria in the control group was Lactobacillaceae (P < 0.01). At the genus level, 79 abundant taxa were identified, enriched bacteria in the infected mice was Streptococcus, while the enriched bacteria in the control group was uncultured_bacterium_f_Eggerthellaceae (P < 0.01). At the species level, 80 abundant taxa were identified, enriched bacteria in the infected mice was uncultured_bacterium_g_Streptococcus, while the enriched bacteria in the control group was uncultured_bacterium_f_Eggerthellaceae (P < 0.01). 39 KEGG pathways were identified that were differentially enriched between the infected and control mice.

Conclusion

This study comprehensively demonstrates the differential intestinal microbiota of infected mice and analyzes the metabolic pathways related to the specific microbiota. This could provide new targets and research direction for the treatment and prevention of diseases caused by E. granulosus s.l.
Towards a Personalized Definition of Prognosis in Philadelphia-Negative Myeloproliferative Neoplasms
Authors: Mora Barbara , Passamonti Francesco
Published: September 2022

Purpose of Review

Philadelphia-negative myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), prefibrotic (pre-), and overt-primary myelofibrosis (primary MF, PMF). PV and ET could evolve into secondary MF (SMF), whose early diagnosis relies on monitoring signs of possible progression. All MPNs have a risk of blast phase (BP), that is associated with a very dismal outcome. Overall survival (OS) is different among MPNs, and disease-specific prognostic scores should be applied for a correct clinical management. In this review, an overview of current prognostic scores in MPNs will be provided.

Recent Findings

The biological complexity of MPNs and its role on the trajectory of disease outcome have led to the design of integrated prognostic models that are nowadays of common use in PMF patients. As for PV and ET, splicing gene mutations could have a detrimental role, but with the limit of the not routinary recommended application of extensive molecular analysis in these diseases. SMF is recognized as a distinct entity compared to PMF, and OS estimates should be calculated by the MYSEC-PM (Myelofibrosis SECondary-prognostic model). Both in PMF and SMF, decisions as selection of patients potentially candidates to allogenic stem cell transplant or that could benefit from an early shift from standard treatment are based not only on conventional prognostic scores, but also on multivariable algorithms.

The expanding landscape of risk prediction for OS, evolution to BP, and SMF progression from PV/ET informs personalized approach to the management of patients affected by MPNs.
Producing Planning Knowledge: How Professional PhD Candidates Bridge Research–Practice Divides
Authors: Bénit-Gbaffou Claire , Williams Glyn
Published: September 2022

This paper addresses an important, but under-studied, pathway for knowledge production in the field of urban planning: the practitioner engaging with academia through the writing of a PhD. Drawing on our own experiences of doctoral mentoring, in dialogue with PhD candidates, we reflect on the questions and challenges this form of knowledge production raises. The paper aims to extend planning theory’s recognition of ‘multiple epistemologies’ (Sandercock, 2003) through a deeper understanding of how planning professionals as authors lead the translation of experiential knowledge into academic knowledge. Understanding why this is so difficult to actually (co)produce should lead us not only to better mentoring, but also to critical reflection on how rigorous and relevant knowledge is defined within planning academia.
Fathers’ parenting stress, parenting styles and children’s problem behavior: the mediating role of parental burnout
Authors: Ping Yifan , Wang Wei , Li Yimin , Li Yongxin
Published: September 2022

Parental duties can be overwhelming, particularly when parents lack sufficient resources to cope with parenting demands, leading to parental burnout. Research has shown that parental burnout is positively related to neglect and abuse behaviors towards their children; however, few studies have examined parental burnout within the family system, including examining parenting styles as an antecedent, and most research has ignored the potential influence of fathers’ parental burnout. This study aimed to explore the influence of fathers’ parenting stress and parenting styles on internalizing and externalizing problem behaviors in a sample of junior high school students and the mediating effect of parental burnout. Questionnaire data from 236 students (56.4% girls) and their fathers (age: M = 39.24, SD = 5.13) were collected on 3 different time points. Fathers were asked to report their parenting stress and parenting styles at Time 1, and parental burnout at Time 2, and students were asked to report their internalizing and externalizing behaviors at Time 3. The results indicated that: (1) fathers’ parenting stress and negative parenting styles were positively related to parental burnout, and fathers’ positive parenting styles were negatively related to parental burnout; (2) fathers’ parental burnout was positively related to children’s internalizing and externalizing problem behavior; and (3) fathers’ parental burnout could mediate the relationship between parenting stress, negative parenting styles, and internalizing and externalizing problem behavior. These results suggested that fathers’ roles in the parenting process were not negligible, and more attention should be given to prevention and intervention methods for fathers’ parental burnout.
Emotion and Mood Blending in Embodied Artificial Agents: Expressing Affective States in the Mini Social Robot
Authors: Fernández-Rodicio Enrique , Maroto-Gómez Marcos , Castro-González Álvaro , Malfaz María , Salichs Miguel Á.
Published: September 2022

Robots that are devised for assisting and interacting with humans are becoming fundamental in many applications, including in healthcare, education, and entertainment. For these robots, the capacity to exhibit affective states plays a crucial role in creating emotional bonding with the user. In this work, we present an affective architecture that grounds biological foundations to shape the affective state of the Mini social robot in terms of mood and emotion blending. The affective state depends upon the perception of stimuli in the environment, which influence how the robot behaves and affectively communicates with other peers. According to research in neuroscience, mood typically rules our affective state in the long run, while emotions do it in the short term, although both processes can overlap. Consequently, the model that is presented in this manuscript deals with emotion and mood blending towards expressing the robot’s internal state to the users. Thus, the primary novelty of our affective model is the expression of: (i) mood, (ii) punctual emotional reactions to stimuli, and (iii) the decay that mood and emotion undergo with time. The system evaluation explored whether users can correctly perceive the mood and emotions that the robot is expressing. In an online survey, users evaluated the robot’s expressions showing different moods and emotions. The results reveal that users could correctly perceive the robot’s mood and emotion. However, emotions were more easily recognized, probably because they are more intense affective states and mainly arise as a stimuli reaction. To conclude the manuscript, a case study shows how our model modulates Mini’s expressiveness depending on its affective state during a human-robot interaction scenario.
How is atrial fibrillation detected in everyday healthcare? Results of a Dutch cohort study
Authors: Verbiest-van Gurp N. , Uittenbogaart S. B. , van de Moosdijk S. C. M. , van Sprang U. F. , Knottnerus J. A. , Stoffers H. E. J. H. , Lucassen W. A. M.
Published: September 2022

Background

Atrial fibrillation (AF) is a common arrhythmia with serious potential consequences when left untreated. For timely treatment, early detection is imperative. We explored how new AF is detected in patients aged ≥ 65 years in Dutch healthcare.

Methods

The study cohort consisted of 9526 patients from 49 Dutch general practices in the usual-care arm of the Detecting and Diagnosing Atrial Fibrillation study. We automatically extracted data from the electronic medical records and reviewed individual records of patients who developed AF. Patient selection started in 2015, and data collection ended in 2019.

Results

We included 258 patients with newly diagnosed AF. In 55.0% of the patients, the irregular heartbeat was first observed in general practice and in 16.3% in the cardiology department. Cardiologists diagnosed most cases (47.3%), followed by general practitioners (GPs; 33.7%). AF detection was triggered by symptoms in 64.7% of the patients and by previous stroke in 3.5%. Overall, patients aged 65–74 years more often presented with symptoms than those aged ≥ 75 years (73.5% vs 60.6%; p = 0.042). In 31.5% of the patients, AF was diagnosed incidentally (‘silent AF’). Silent-AF patients were on average 2 years older than symptomatic-AF patients. GPs less often diagnosed silent AF than symptomatic AF (21.0% vs 39.0%; p = 0.008), whereas physicians other than GPs or cardiologists more often diagnosed symptomatic AF than silent AF (34.6% vs 11.9%; p < 0.001). Most diagnoses were based on a 12-lead electrocardiogram (93.8%).

Conclusion

Diagnosing AF is a multidisciplinary process. The irregular heartbeat was most often detected by the GP, but cardiologists diagnosed most cases. One-third of all newly diagnosed AF was silent.
Effect of Vanadium on the Microstructure and Mechanical Properties of 2100 MPa Ultra-High Strength High Plasticity Spring Steel Processed by a Novel Online Rapid-Induction Heat Treatment
Authors: Dai Qi-Lei , Li Kun , Meng Kai-Ren , Fang Zhou , Chen Wen , Yang Tian-Bao , Feng Chi , Wu Jin-Ming , Misra R. D. K.
Published: September 2022

Advanced automotive industries generate large demand for the next generation of high strength and high toughness spring steels. Vanadium-containing 55SiCrV spring steels subjected to rapid-induction heating treatment can fulfil such requirements. However, the effect of vanadium microalloying under online rapid-induction heat treatments is rarely reported. A comparative study of the microstructure and tensile properties of 55SiCr and 55SiCrV spring steel wires subjected to a novel online rapid induction heat treatment has been demonstrated herein. It is found that the tensile strength of the 55SiCr spring wire decreases with the decrease in the wire speed in online rapid-induction heating, and the plasticity increases. Whereas, the tensile strength of the 55SiCrV steel wire increases with the decrease in the wire speed with the retained high plasticity, which is attributed to the strengthening effect of the dislocations. Through the optimized rapid-induction heating/cooling thermal cycles and intermediate-temperature tempering treatment, the tensile strength of the 55SiCrV steel wire approaches 2106 MPa with total elongation of 9.7%. Compared with the 55SiCr spring steel, the addition of V in 55SiCrV spring steel changes the strengthening and toughening mechanisms via the grain refinement and enhancement in the hardenability and tempering resistance. The finely dispersed V-containing secondary phases are rarely found in the matrix, which indicates that the precipitation effect stemming from the addition of V is not the dominant strengthening factor in the online rapid-induction heat process. The proposed novel online rapid-induction heat treatment provides a promising pathway for the mechanical property improvement of the spring steel.

Graphical Abstract
Effect of exfoliated MoS2 on the Microstructure, Hardness, and Tribological Properties of Copper Matrix Nanocomposite Fabricated via the Hot Pressing Method
Authors: Yehia Hossam M. , Ali Ahmed I. , Abd-Elhameed Ehab
Published: September 2022

In this study, copper matrix composites were prepared using the cold and hot pressing technique and then investigated to select the suitable one for the self-lubricating applications. A hybrid of alumina and molybdenum disulfide with a 1:1 ratio by the mechanical milling for 40 h was proceeded to peel the molybdenum disulfide and cover the alumina particles with their layers. Three different samples like Cu, Cu/10 Al2O3, and Cu/hybrid 20(Al2O3–MoS2) were mixed for 15 h. The ball-to-powder ratio in the two mentioned steps was 10:1. The X-ray analysis, HRTEM, Raman spectra, and scanning electron miscopy were used to study the crystal structure, chemical composition, and morphology of the new hybrid and prepared samples. The density was evaluated by the Archimedes method. Mechanical properties, including hardness, wear rate, and coefficient of friction, were investigated. The mixing for 15 h improves the exfoliation of MoS2 flakes inside the copper matrix. A clear hardness improvement was achieved by adding alumina and the mixture of (Al2O3–MoS2). The copper sample reinforced with the hybrid of alumina/MoS2 gave the lowest mechanical wear rate and the lowest average friction coefficient of 0.17.
Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study
Authors: Shishido Koki , Ando Kenji , Ito Yoshiaki , Takamisawa Itaru , Yajima Junji , Kimura Takeshi , Kadota Kazushige , Saito Shigeru
Published: September 2022

The aim of this study is to evaluate the long-term safety and efficacy of the 2.25 mm bioresorbable-polymer sirolimus-eluting Ultimaster stent in a Japanese patient population. Treatment of coronary artery disease in very small vessels is associated with an increased risk for cardiac events. The CENTURY JSV study is a prospective, multicenter, single-arm study. Seventy patients with stable and unstable coronary artery disease with a coronary lesion eligible for implantation with a 2.25 mm stent were enrolled in this study. Patients underwent clinical follow-up through 5-year after the PCI procedure. The mean age was 70.4 ± 9.2 years. The prevalence of diabetes mellitus was 37.1%, all not insulin dependent. The incidence of major adverse cardiac events, defined as cardiac death, target vessel myocardial infarction (MI), and clinically driven target lesion revascularization (CD-TLR) at 5 years was 5.7%. A non-Q wave MI was noted in 1.4% and 4.3% underwent a CD-TLR. There was no stent thrombosis during the entire follow-up period. No cardiac events were reported between 2 and 5 years. This is the first study to demonstrate safety and effectiveness for 5 years after treatment of very small coronary disease with 2.25 mm-diameter DES.

Clinical trial registration: UMIN000012928
A Mixed Model for Assessing the Effect of Numerous Plant Species Interactions on Grassland Biodiversity and Ecosystem Function Relationships
Authors: McDonnell Jack , McKenna Thomas , Yurkonis Kathryn A. , Hennessy Deirdre , de Andrade Moral Rafael , Brophy Caroline
Published: September 2022

In grassland ecosystems, it is well known that increasing plant species diversity can improve ecosystem functions (i.e., ecosystem responses), for example, by increasing productivity and reducing weed invasion. Diversity-Interactions models use species proportions and their interactions as predictors in a regression framework to assess biodiversity and ecosystem function relationships. However, it can be difficult to model numerous interactions if there are many species, and interactions may be temporally variable or dependent on spatial planting patterns. We developed a new Diversity-Interactions mixed model for jointly assessing many species interactions and within-plot species planting pattern over multiple years. We model pairwise interactions using a small number of fixed parameters that incorporate spatial effects and supplement this by including all pairwise interaction variables as random effects, each constrained to have the same variance within each year. The random effects are indexed by pairs of species within plots rather than a plot-level factor as is typical in mixed models, and capture remaining variation due to pairwise species interactions parsimoniously. We apply our novel methodology to three years of weed invasion data from a 16-species grassland experiment that manipulated plant species diversity and spatial planting pattern and test its statistical properties in a simulation study.Supplementary materials accompanying this paper appear online.
Long non-coding RNA DUXAP10 exerts oncogenic properties in osteosarcoma by recruiting HuR to enhance SOX18 mRNA stability
Authors: Wang Guantong , Zhang Qian , Wang Qinjue , Wang Jing , Chen Lulu , Sun Qiang , Miao Dengshun
Published: September 2022

Recent studies have demonstrated that several long non-coding RNAs (lncRNAs) play an important role in the occurrence and development of osteosarcoma (OS). However, more lncRNAs and their mechanisms in regulating growth and migration of OS cells remain to be investigated. In this study, we identified an lncRNA called DUXAP10 by analysis of GEO data, which was significantly up-regulated in OS tissues and cell lines. Experiments in vitro revealed that lncRNA DUXAP10 promoted proliferation, migration, and invasion of OS cells and inhibited their apoptosis. We also demonstrated that DUXAP10 promoted the formation and growth of OS by tumor formation assay. Furthermore, SOX18 was identified as a critical downstream target of DUXAP10 by transcriptome RNA-seq. Mechanistically, DUXAP10 mainly localized in cytoplasm and could specifically bind to HuR to increase the stability of SOX18 mRNA. Meanwhile, SOX18 knockdown largely reversed increased proliferation of OS cells induced by DUXAP10 overexpression. Findings from this study indicate that lncRNA DUXAP10 can act as an oncogene in osteosarcoma by binding HuR to up-regulate the expression of SOX18 at a post-transcriptional level, which may provide a new target for OS clinical diagnosis and treatment.
Rice residue management in the Indo-Gangetic Plains for climate and food security. A review
Authors: Kaur Manpreet , Malik Dharm Pal , Malhi Gurdeep Singh , Sardana Virender , Bolan Nanthi S. , Lal Rattan , Siddique Kadambot H. M.
Published: September 2022

This paper reviews and analyzes the impact of residue burning on the environment and human health, and the influence of ex-situ and in-situ residue management on reducing pollution and improving soil health, crop yield, and farmers’ economic benefits. Paddy is cultivated on 43.8 Mha in India, producing 118.43 Mt grain and an estimated 165.8 Mt straw. Burning is the most common practice for managing rice crop residues mainly due to its simplicity, low cost, increased mechanical harvesting, short window between rice harvest and wheat sowing, and lack of viable uses for residues. Around 50 Mt of rice straw is burned annually, nearly half of which occurs in northwestern India during October/November. Burning residue is a major contributor to air pollution, emitting around 1.5 Mt particulate matter, 150 Mt carbon dioxide, and other greenhouse gases (e.g., NO2, SO2, CO, CH4, NH3) and volatile organic compounds, resulting in a wide range of respiratory infections in humans, reduced soil nutrient and carbon inputs, and disturbed soil microbial activity. In-situ residue management using a Happy Seeder, Super straw management system, paddy straw chopper cum spreader, reversible moldboard plow, or no-till seeder incorporates or mulches residues, avoiding burnings. These operations are economically profitable as they reduce costs, increase yields, or both. In-situ residue management, i.e., incorporation or mulching improves the soil’s physical, chemical and biological properties and is considered better for improving soil health than residue removal. Ex-situ residue management for biofuel, biochar, electricity generation or bale making is also profitable for the environment and reduces pollutant emissions.
Detection of diphtheria toxin production by toxigenic corynebacteria using an optimized Elek test
Authors: Melnikov Vyacheslav G. , Berger Anja , Sing Andreas
Published: September 2022

Purpose

Diphtheria, still present in many countries of the world, is caused by toxigenic strains of species of the Corynebacterium diphtheriae complex, mainly Corynebacterium diphtheriae and the emerging zoonotic pathogen C. ulcerans. The immunoprecipitation test according to Elek is the gold standard for detection of the major virulence factor diphtheria toxin (DT) in toxigenic corynebacteria. Due to its sophisticated methodological requirements, the classical Elek test is performed mainly by specialized reference laboratories. It was revealed that the current modification of the Elek test does not detect the toxin in weakly toxigenic isolates. Therefore, a more robust method for detecting free DT is urgently needed, especially for toxigenic C. ulcerans strains which are known to produce often much lower amounts of DT than C. diphtheriae.

Methods

Thirty-one tox-positive C. ulcerans isolates with a negative standard Elek test result previously determined as NTTB (non-toxigenic tox bearing) were re-analyzed in this study using a modified immunoprecipitation method optimized regarding different parameters including type and concentration of antitoxin, medium volume, inoculum distance from the antitoxin disk and position of controls.

Results

All 31 C. ulcerans strains tested positive in the optimized Elek test.

Conclusion

Only with a reliable and easy-to-handle method for detecting the toxigenicity of C. ulcerans, it is possible to assess the etiological role of this emerging zoonotic bacterium in human pathology.
SARS-CoV-2 variants and the risk of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 among children in Germany
Authors: Sorg A. L. , Schönfeld V. , Siedler A. , Hufnagel M. , Doenhardt M. , Diffloth N. , Berner R. , v. Kries R. , Armann J.
Published: September 2022

Purpose

To investigate the relationship between the risk of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in children and the predominance of different SARS-CoV-2 variants of concern (VOC) over time.

Methods

In relation to the Alpha, Delta, and Omicron VOC phases of the pandemic, the risk of developing PIMS-TS was calculated by analyzing data for rtPCR-confirmed SARS-CoV-2 infections reported to the German statutory notification system, along with data captured by a separate, national PIMS-TS registry. Both overall infection rates and age group-specific ratios of PIMS-TS during the different pandemic phases were calculated using the Alpha period as the baseline.

Results

The PIMS-TS rate changed significantly over time. When the Alpha VOC was dominant [calendar week (CW) 11 in March–CW 31 in August 2021], the PIMS-TS rate was 6.19 [95% confidence intervals (95% CI) 5.17, 7.20]. When Delta prevailed (CW 32 in August 2021–CW 4 in January 2022), the rate decreased to 1.68 (95% CI 1.49, 1.87). During the Omicron phase (CW 5 in January–CW 16 in April 2022), the rate fell further to 0.89 (95% CI 0.79, 1.00). These changes correspond to a decreased PIMS-TS rate of 73% (rate ratio 0.271, 95% CI 0.222; 0.332) and 86% (rate ratio 0.048, 95% CI 0.037; 0.062), respectively, in comparison to the Alpha period. Rate ratios were nearly identical for all age groups.

Conclusion

The data strongly suggest an association between the risk for PIMS-TS and the prevailing VOC, with highest risk related to Alpha and the lowest to Omicron. Given the uniformity of the decreased risk across age groups, vaccination against SARS-CoV-2 does not appear to have a significant impact on the risk of children developing PIMS-TS.
Construction and validation of an early warning model for predicting the acute kidney injury in elderly patients with sepsis
Authors: Xin Qi , Xie Tonghui , Chen Rui , Wang Hai , Zhang Xing , Wang Shufeng , Liu Chang , Zhang Jingyao
Published: September 2022

Background

Sepsis-induced acute kidney injury (S-AKI) is a significant complication and is associated with an increased risk of mortality, especially in elderly patients with sepsis. However, there are no reliable and robust predictive models to identify high-risk patients likely to develop S-AKI. We aimed to develop a nomogram to predict S-AKI in elderly sepsis patients and help physicians make personalized management within 24 h of admission.

Methods

A total of 849 elderly sepsis patients from the First Affiliated Hospital of Xi’an Jiaotong University were identified and randomly divided into a training set (75%, n = 637) and a validation set (25%, n = 212). Univariate and multivariate logistic regression analyses were performed to identify the independent predictors of S-AKI. The corresponding nomogram was constructed based on those predictors. The calibration curve, receiver operating characteristics (ROC)curve, and decision curve analysis were performed to evaluate the nomogram. The secondary outcome was 30-day mortality and major adverse kidney events within 30 days (MAKE30). MAKE30 were a composite of death, new renal replacement therapy (RRT), or persistent renal dysfunction (PRD).

Results

The independent predictors for nomogram construction were mean arterial pressure (MAP), serum procalcitonin (PCT), and platelet (PLT), prothrombin time activity (PTA), albumin globulin ratio (AGR), and creatinine (Cr). The predictive model had satisfactory discrimination with an area under the curve (AUC) of 0.852–0.858 in the training and validation cohorts, respectively. The nomogram showed good calibration and clinical application according to the calibration curve and decision curve analysis. Furthermore, the prediction model had perfect predictive power for predicting 30-day mortality (AUC = 0.813) and MAKE30 (AUC = 0.823) in elderly sepsis patients.

Conclusion

The proposed nomogram can quickly and effectively predict S-AKI risk in elderly sepsis patients within 24 h after admission, providing information for clinicians to make personalized interventions.
The prevention of falls in patients with Parkinson’s disease with in-home monitoring using a wearable system: a pilot study protocol
Authors: Campani Daiana , De Luca Enrico , Bassi Erika , Busca Erica , Airoldi Chiara , Barisone Michela , Canonico Massimo , Contaldi Elena , Capello Daniela , De Marchi Fabiola , Magistrelli Luca , Mazzini Letizia , Panella Massimiliano , Scotti Lorenza , Invernizzi Marco , Dal Molin Alberto
Published: September 2022

Background

Parkinson's disease (PD) is a chronic, progressive neurodegenerative condition that gradually worsens motor function and leads to postural instability and, eventually, falls. Several factors may influence the frequency of future falls, such as slowness, freezing of gait, loss of balance, and mobility problems, cognitive impairments, and the number of previous falls. The TED bracelet is an advanced technological wearable device able to predict falls.

Aims

This principal aim is to investigate the feasibility of a full-scale research project that uses the TED bracelet to identify whether individuals with PD are at risk of falling.

Methods

This study will involve a pilot prospective observational study design; the subjects will include 26 patients suffering from mild PD and 26 others with no PD and no gait problems. Data will be collected from the TED bracelet and then compared to a paper-based fall diary. The enrolled participants will have a scheduled outpatient evaluation to collect both clinical and instrumental data as well as biological samples.

Discussion

This pilot study could then be implemented in a larger form to further evaluate the effectiveness of the TED device. Finally, it will help further develop gait monitoring systems for people with Parkinson's disease and other neurodegenerative diseases that can affect physical function and mobility, such as dementia and Alzheimer's.

Conclusions

Preventing falls and their complications could lead to major advancements in the quality of home care for patients with PD, which would significantly impact the quality of life of both these patients and their caregivers.
The psychosocial needs of patients who have chronic kidney disease without kidney replacement therapy: a thematic synthesis of seven qualitative studies
Authors: Seery Christina , Buchanan Sarah
Published: September 2022

Background

Limited quantitative data suggests that patients who have chronic kidney disease without kidney replacement therapy (CKD without KRT) may present with psychosocial needs just as patients who have acute kidney injury and are treated by dialysis (AKI stage 3D) do. This systematic review aims to synthesise qualitative research on patients’ experiences of CKD without KRT to provide further insight into patients’ experience of the healthcare they receive and simultaneously, their psychosocial needs, to inform the development of appropriate psychological interventions.

Methods

The review followed ENTREQ guidelines. PubMed/MEDLINE, PsycINFO, EMBASE and CINAHL were searched in July and August 2021. Qualitative studies in English on the experiences of CKD without KRT care were included in the review. Thematic synthesis was conducted on the findings of the included studies.

Results

The search identified 231 articles for screening. Eight studies met the inclusion criteria, and one was excluded at the quality assessment stage. The final seven articles [n = 130 patients] were analysed. Five themes on psychosocial needs were developed: addressing patients’ CKD-related educational needs, supporting the patient’s relationships, honouring the patient’s need for control, adjusting to change, and recognising fear of disease and treatment.

Discussion

This review highlights the range of psychosocial needs of patients who have CKD without KRT. There are numerous intervention options that clinicians may develop that could benefit patients and address multiple needs, such as group educational programmes.

Graphical abstract
Printable Aligned Single-Walled Carbon Nanotube Film with Outstanding Thermal Conductivity and Electromagnetic Interference Shielding Performance
Authors: Zeng Zhihui , Wang Gang , Wolan Brendan F. , Wu Na , Wang Changxian , Zhao Shanyu , Yue Shengying , Li Bin , He Weidong , Liu Jiurong , Lyding Joseph W.
Published: September 2022

Ultrathin, lightweight, and flexible aligned single-walled carbon nanotube (SWCNT) films are fabricated by a facile, environmentally friendly, and scalable printing methodology. The aligned pattern and outstanding intrinsic properties render “metal-like” thermal conductivity of the SWCNT films, as well as excellent mechanical strength, flexibility, and hydrophobicity. Further, the aligned cellular microstructure promotes the electromagnetic interference (EMI) shielding ability of the SWCNTs, leading to excellent shielding effectiveness (SE) of ~ 39 to 90 dB despite a density of only ~ 0.6 g cm−3 at thicknesses of merely 1.5–24 µm, respectively. An ultrahigh thickness-specific SE of 25 693 dB mm−1 and an unprecedented normalized specific SE of 428 222 dB cm2 g−1 are accomplished by the freestanding SWCNT films, significantly surpassing previously reported shielding materials. In addition to an EMI SE greater than 54 dB in an ultra-broadband frequency range of around 400 GHz, the films demonstrate excellent EMI shielding stability and reliability when subjected to mechanical deformation, chemical (acid/alkali/organic solvent) corrosion, and high-/low-temperature environments. The novel printed SWCNT films offer significant potential for practical applications in the aerospace, defense, precision components, and smart wearable electronics industries.
Metal–Organic Framework Materials for Electrochemical Supercapacitors
Authors: Cao Ziwei , Momen Roya , Tao Shusheng , Xiong Dengyi , Song Zirui , Xiao Xuhuan , Deng Wentao , Hou Hongshuai , Yasar Sedat , Altin Sedar , Bulut Faith , Zou Guoqiang , Ji Xiaobo
Published: September 2022

Exploring new materials with high stability and capacity is full of challenges in sustainable energy conversion and storage systems. Metal–organic frameworks (MOFs), as a new type of porous material, show the advantages of large specific surface area, high porosity, low density, and adjustable pore size, exhibiting a broad application prospect in the field of electrocatalytic reactions, batteries, particularly in the field of supercapacitors. This comprehensive review outlines the recent progress in synthetic methods and electrochemical performances of MOF materials, as well as their applications in supercapacitors. Additionally, the superiorities of MOFs-related materials are highlighted, while major challenges or opportunities for future research on them for electrochemical supercapacitors have been discussed and displayed, along with extensive experimental experiences.
BIM-Based Safety Leading Indicators Measurement Tool for Construction Sites
Authors: Dadashi Haji Mostafa , Behnam Behrouz , Sebt Mohammad Hassan , Ardeshir Abdollah , Katooziani Ali
Published: September 2022

Recognition of safety leading indicators is considered as an important part of safety management in construction projects to prevent hazardous accidents occurrence. In the available literature, the lack of a comprehensive proactive approach for assessing safety, based on active safety leading indicators is tangible. In this study, BIM and knowledge base are integrated to develop a safety management framework, then, this framework is implemented in a case study to assess its performance. Safety leading indicators are extracted from experts’ expertise, documents, and best practice, and then the relationships among safety leading indicators, activities, and their attributes are established; these pieces of knowledge are stored in a safety leading indicator knowledge base. To measure the impacts of these indicators on the project, a framework is developed to integrate the knowledge base and building information modeling (BIM). The developed add-on generates a heat-map to visualize the impacts of the safety leading indicators on a daily basis, and it also produces a textual result sheet. To verify the effectiveness and efficiency of the developed tool a survey from professionals is conducted. This tool provides a way to automatically assess the impacts of the safety leading indicators. Using its results, safety managers and project participants can make important decisions to reduce hazards. The results also indicate that accidents occurring in the construction site dropped by 38% after employing the presented framework.
Potentials of oxymethylene-dimethyl-ether in diesel engine combustion
Authors: Saupe Christopher , Atzler Frank
Published: September 2022

The increasing CO2 concentration in the atmosphere and the resulting climate change require an immediate and efficient reduction of anthropogenic carbon-dioxide emission. This target can be achieved by the usage of CO2-neutral fuels even with current technologies (Schemme et al. in Int J Hydrogen Energy 45:5395–5414, 2020). Diesel engines in particular are amongst the most efficient prime movers. Using oxymethylene-dimethyl-ether (OME) it is possible to solve the hitherto existing Soot-NOx-Trade-off. OME has bounded oxygen in the molecular chain. This reduces the formation of soot, but equally the calorific value. But in considerance of the physical and chemical properties of OME, it could be useful to optimize the standard diesel engine into an OME engine. As a result, single-cylinder tests were performed to obtain a detailed analysis of the differences between OME3-5 and commercially available DIN EN 590 Diesel. Based on the fact that OME has gravimetrically less than half the calorific value of diesel, twice the fuel mass must be injected for the same energy release in the combustion chamber. Therefore, at the beginning of the investigations, a variation of the injector flow rate was carried out by means of different nozzle hole diameters. The evaluation of the results included the fundamental differences in the combustion characteristics of both fuels and the determination of efficiency-increasing potentials in the conversion of OME3-5. Due to the lower ignition delay and the shorter combustion time of OME, potentials in the optimisation of the injection setting became apparent. Higher energy flows over the combustion chamber wall were noticeable in operation with OME. To get to the bottom of this, the single-cylinder investigations were supported by tests on the optically accessible high-pressure chamber and the single-cylinder transparent engine. The optical images showed a narrower cone angle and greater penetration depth of the OME injection jet compared to the diesel injection jet. This confirmed the results from the single-cylinder tests. This provides further potential in the design of the injector nozzle to compensate for these deficits. Overall, this work shows that operation with OME in a classic diesel engine is possible without any significant loss in efficiency and with little effort in the hardware. However, it is also possible to achieve more efficient use of the synthetic fuel with minor adjustments.
Does engagement help to reduce insomnia when workers are emotionally exhausted?
Authors: Fernández-Salinero Samuel , Topa Gabriela , Fernández Muñoz Juan José
Published: September 2022

Insomnia is one of the most common problems, affecting more than 35% of the world’s population. To achieve a better understanding of this problem the focus of this research is to understand how emotional exhaustion at work may lead to insomnia. To help to combat it, we tested a mediation model including engagement factors. The sample was composed of 823 participants. 38.3% (315 subjects) were male and 61.7% (508 subjects) were female. Mean age was 42.65 years old (9.05 = SD). Main results showed that emotional exhaustion is directly and statistically significant related to insomnia. However, different engagement factors showed different weights in buffering this relationship. Emotional exhaustion showed a statistically significant impact on insomnia. Vigor and absorption helped to buffer the impact of emotional exhaustion over insomnia. Our study has some limitations. First, the sample was acquired by not aleatory processes. Another limitation is that our sample was composed of individuals with decision-making capacity. Lastly, our research is a transversal study. Future research should take these limitations into account and conduct longitudinal research with aleatory sampling procedures.
Usability of clinical decision support systems
Authors: Mucha Henrik , Robert Sebastian , Breitschwerdt Rüdiger , Fellmann Michael
Published: September 2022

Usability is considered a major success factor for current and future decision support systems. Such systems are increasingly used to assist human decision-makers in high-stakes tasks in complex domains such as health care, jurisdiction or finance. Yet, many if not most expert systems—especially in health care—fail to deliver the degree of quality in terms of usability that its expert users are used to from their personal digital consumer products. In this article, we focus on clinical decision support systems (CDSS) as an example for how important a human-centered design approach is when designing complex software in complex contexts. We provide an overview of CDSS classes, discuss the importance of systematically exploring mental models of users, and formulate challenges and opportunities of future design work on CDSS. We further provide a case study from a current research project to illustrate how we used codesign as a practical approach to produce usable software in a real-world context.

Practical Relevance: We make a point for usability to be considered a major success factor and non-negotiable characteristic of expert software. With software evolving into virtual coworkers in terms of supporting human decision-making in complex, high-risk domains, the necessity of and demand for systems that are unambiguously understandable and interpretable for their expert users have never been higher. We show that this is a real-world problem with high practical relevance by describing our work in the domain of clinical decision support systems (CDSS) as an example. We introduce the topic and a classification of CDSS. Thus, we highlight a conceptual framework of how to approach complex domains from a technology designer’s point of view. We continue by explaining why usability must be regarded as a major goal in software development. We derive challenges and opportunities that may well be transferred to other domains. Finally, be including a real-world example from our own professional work we propose a practical approach towards taking the challenges and exploiting the associated opportunities.
Effects of the Fractionation of the Nitrogen Fertilization on Root Nitrate Uptake and Vine Agronomic Performance in Pinot Gris Grapevines in a Temperate Climate
Authors: Zanin Laura , Nerva Luca , Alessandrini Massimiliano , Tomasi Diego , Pinton Roberto , Lucchetta Marco , Chitarra Walter , Gaiotti Federica
Published: September 2022

The study aims to investigate at a physiological and molecular level the root absorption of nitrogen (N) during the annual cycle of grapevine. The study was performed on potted Pinot Gris plants grafted on Kober 5BB and grown for two consecutive years in a semi-controlled environment (Northeast, Italy). The study compared the response of plants N-fertilized in spring (T1), or in spring and in post-harvest (T2) or no-N fertilized (C). Results showed that under our climate conditions nitrate was taken up by the grapevines when applied both in spring or in spring and post-harvest. The nitrate acquisition in T1 roots is mediated at molecular and physiological level by a higher activation of high-affinity nitrate-transport system to take up nitrate in comparison to no-fertilized plants. Comparing the two N fertilization managements, the dynamic of nitrate uptake rates showed different patterns with an overall late response of High-Affinity Transport System when the application of part of N-fertilization was delayed to post-harvest (T2) in comparison to T1. Nevertheless, during the 2 years of the trial the fractionation of N fertilization applied in spring and post-harvest did not negatively affect the yield and quality parameters of vines. An increase of N concentration in T2 roots after two consecutive growing seasons may suggest that the fractionation can lead to beneficial effects on long period. Results of this work contribute to improve the comprehension of N acquisition in grapevine in order to optimize the use of N inputs in vineyard.