bluuebunny/crossref_metadata_2025 huggingface dataset:
Possibilities of Using Complex Natural Medicines in Patients with Osteoarthritis (Fredulex)
Authors: Тябут Т.Д. , Кундер Е.В. , Буглова А.Е. , Руденко Е.В.
Published: March 2022

В статье изложены современные представления о фенотипах остеоартрита (ОА), принципах немедикаментозного и медикаментозного лечения, предложенных в международных рекомендациях. Представлены основные результаты публикаций, рассматривающих возможности применения компонентов лекарственных растений и нутрицевтиков (босвеллия, куркума, экстракт черного перца, гиалуроновая кислота, коллаген) у пациентов с остеоартритом с учетом их эффективности и безопасности.

The article presents current views on the phenotypes of osteoarthritis (OA), principles of non-pharmacological treatment and pharmacological therapy proposed in the international recommendations. We have summarized main results of publications considering the possibility of using medicinal plant components and nutraceuticals (Boswellia, turmeric, black pepper extract, hyaluronic acid, collagen) in patients with osteoarthritis with regard to their effectiveness and safety.
How Microbiota Forms Rheumatic Diseases? Part 2
Authors: Рудой А.С.
Published: March 2022

В кишечнике человека обитает чрезвычайно разнообразное и обильное микробное сообщество, которое корректирует и даже модулирует многие процессы, связанные со здоровьем. «Интерфейсы» слизистой оболочки являются особенно активными участками взаимодействия микроорганизмов и хозяев. Возрастающее понимание характерного состава и функции микробиоты кишечника выявило, что она не только участвует в поддержании целостности слизистой оболочки, но и затрагивает гомеостаз системы иммунитета с формированием как локальных, так и системных иммунных реакций. В представленном обзоре рассмотрена роль нарушений устойчивого состояния и взаимодействия хозяин – микроорганизм, которые могут потенциально влиять на развитие и прогрессирование ревматических заболеваний. В заключение будут рассмотрены вопросы новых терапевтических целей коррекции микробиоты.

The human gut harbours a tremendouslydiverse and abundant microbial community that corrects and even modulates many health-related processes. The “interfaces” of the intesinal mucous of in are particularly active sites of interaction between microorganisms and hosts. Growing insight into the characteristic composition and function of the gut microbiota has revealed that it is involved not only in maintaining the integrity of the mucous membrane, but also affects the homeostasis of the immune system with the formation of both local and systemic immune responses. This review considers in the host – microorganism interplay, which can potentially affect the development and progression of rheumatic diseases. In conclusion, the issues of new therapeutic goals of microbiota correction will be consider.
Correction of Reproductive Disorders in Women with Multiple Drug-Resistant Tuberculosis
Authors: Солонко И.И. , Скрягина Е.М. , Рогова З.И.
Published: March 2022

Приведен алгоритм лечения нарушений репродуктивной функции у женщин с туберкулезом с множественной лекарственной устойчивостью (МЛУ-ТБ), который включал установление типа репродуктивных нарушений, гормональную коррекцию, консультирование и лечение у смежных специалистов. Показано, что адекватная гормональная терапия в течение 3 месяцев способствовала нормализации гормонального профиля, маточной перфузии и становлению ритмичного менструального цикла у 94,1% пациенток. Комплексный подход к коррекции нарушений репродуктивной функции у пациенток с туберкулезом, основанный на учете показателей эндокринного профиля, позволяет предупредить развитие нежелательной беременности, повышает приверженность к лечению основного заболевания и улучшает репродуктивный прогноз.

An algorithm for treating reproductive disorders in women with multiple drug-resistant tuberculosis (MDR-TB) is presented, which includes establishing the type of reproductive disorder, hormonal correction, counselling, and treatment by related specialists. It was showed that adequate hormone therapy for 3 months contributed to normalization of hormonal profile, uterine perfusion, and formation of rhythmic menstrual cycle in 94.1% of patients. A comprehensive approach to the correction of reproductive disorders in patients with tuberculosis, based on endocrine profile indicators, lets to prevent the development of unwanted pregnancies, increases commitment to the treatment of the main disease, and improves reproductive prognosis.
Acute Gastroenteritis in Children. Updated ESPGHAN 2020 Guidelines
Authors: Белоусова О.Ю.
Published: March 2022

Острые кишечные инфекции занимают второе место в структуре инфекционных заболеваний, уступая только респираторным инфекциям. Высокая частота острых кишечных инфекций у детей, большая часть из которых приходится на пациентов раннего возраста, определяет необходимость разработки современных рекомендаций по их диагностике и лечению. При этом длительность заболевания и его исход напрямую зависят от своевременности и адекватности назначенной терапии. Что касается применения пробиотиков, известно, что различные пробиотические штаммы отличаются по своим клиническим эффектам.Обзор проблемы основывается на рекомендациях Европейского общества детских гастроэнтерологов, гепатологов, диетологов (ESPHGAN), содержащих обновленные рекомендации по использованию пробиотиков для лечения острого гастроэнтерита у младенцев и детей, которые раньше считались здоровыми. С момента публикации в 2014 году Руководства Рабочей группы ESPGHAN по пробиотикам и пребиотикам в отношении пробиотиков для лече ния острого гастроэнтерита появились новые доказательства эффективности пробиотиков. В связи с появившимися новыми данными, полученными с учетом доказательной медицины, документ был обновлен 2020 году.

High prevalence of acute enteric infections in children, the majority of which affects infants, determines the necessity of development of modern recommendation on diagnostics and treatment of such conditions. However, disease duration and outcome depend on timelines and adequacy of the prescribed treatment. Acute intestinal infections occupy the second place in the structure of infectious diseases, second only to respiratory infections. With regard to the use of probiotics, it is known that different probiotic strains differ in their clinical effects.The review is based on the recommendations of the European Society of Pediatric Gastroenterology, Hepatology, Nutritional Medicine (ESPHGAN), which contains updated recommendations for the use of probiotics for the treatment of acute gastroenteritis in infants and children previously considered healthy. Since the publication of the ESPGHAN Probiotics and Prebiotics Working Group Guidelines for Probiotics for Acute Gastroenteritis in 2014, new evidence has emerged for the effectiveness of probiotics. In connection with the emerging new data obtained taking into account evidence- based medicine, the document was updated in 2020.
PENERAPAN STRATEGI GREEN MARKETING DI TENGAH PANDEMI COVID-19
Authors: Rahmawati Meylin , Pratiwi Sulistya Rini , Devi Charitin , Nainggolan Yohanna Thresia
Published: March 2022

Perusahaan yang menerapkan green marketing sebagai strategi pemasarannya, dianggap lebih mudah dalam membangun citra positif perusahaan. Terlebih ketika perusahaan yang menerapkan green marketing adalah perusahaan dengan produk yang dipasarkan di pasar internasional. Tujuan penelitian ini adalah untuk mengetahui bagaimana penerapan green marketing pada UMKM di era pandemi covid-19 beserta dampaknya. Penelitian ini sekaligus bertujuan relevansinya penerapan green marketing sebagai alat pemasaran dalam situasi bisnis yang tidak pasti karena pandemi Covid-19. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif. Implementasi strategi green marketing membutuhkan pendekatan fundamental, komprehensif dan terintegrasi dalam semua aspek fungsional pemasaran, termasuk bauran pemasaran secara keseluruhan, seperti desain produk, harga, lokasi dan promosi.
Edukasi Pencegahan Penularan COVID-19 dengan Metode Lomba Menggambar
Authors: Nurfitri Nurfitri , Hatta Muhammad , Pawenrusi Esse Puji , Lodar Matheus Costantinus , Najihah Najihah
Published: March 2022

Pandemi COVID-19 adalah krisis mematikan yang memiliki efek yang jauh jangkauannya. Virus telah mempengaruhi gaya hidup di seluruh dunia. Untuk mengurangi penyebaran COVID-19 pembelajaran sepenuhnya dilakukan secara online, hal ini mengancam kesejahteraan sosial-emosional siswa sehingga dibutuhkan edukasi dengan metode yang menarik untuk siswa dalam memahami pencegahan penularan COVID-19. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan siswa terhadap pencegahan penulara COVID-19 dan menjaga kesejahteraan sosial-emosional siswa dengan metode lomba menggambar. Metode pelaksanaan pada kegiatan ini adalah pemberian edukasi melalui leaflet, tanya jawab dan lomba menggambar tentang pencegahan penulara COVID-19. Hasil dari kegiatan pengabdian masyarakat yang telah dilakukan adanya peningkatan pengetahuan dan pemahaman siswa tentang pencegahan dan penularan COVID-19 di SDN 149 LEMBANG dan siswa merasa senang dan sangat berantusias dalam mengikuti lomba menggambar sehingga dapat menjaga emosi siswastabil dan tidak stres menghadapi pandemi COVID-19.
Comparative Analysis of the Chemical Composition of Natural Waters in the Khanty-Mansiysky and Yamalo-Nenets Autonomous Districts
Authors: Korchina TYa , Korchin VI
Published: March 2022

Background: Water is a key source of life on Earth; it is involved in the transfer of nutrients, macro- and microelements between soil, plants, animals and humans, as well as in the concentration and dispersion of chemical elements and the formation of minerals. The elemental status of the population is largely determined by the chemical composition of the natural waters on the territory of residence. Objective: To perform a comparative analysis of the concentrations of iron, manganese, calcium and magnesium in natural waters of the Khanty-Mansiysk and Yamalo-Nenets Autonomous Districts (Okrugs). Materials and methods: We established concentrations of iron, manganese, calcium and magnesium in 100 samples of natural waters taken from rivers, lakes, backwaters, channels, etc. of the Khanty-Mansiysk and Yamalo-Nenets Autonomous Districts, 50 samples each, using spectrophotometry, capillary electrophoresis and atomic absorption spectrometry. The results obtained were compared with the reference values provided in Russian sanitary rules and regulations SanPiN 1.2.3685–21. Results: We established elevated levels of iron in most surface water samples from both districts and of manganese in the Khanty-Mansi Autonomous Okrug accompanied by extremely low concentrations of Ca and Mg in the vast majority of all samples. At the same time, we registered significantly lower concentrations of Ca (p = 0.012) and Mg (p = 0.021) in the water samples from the Yamalo-Nenets Autonomous Okrug compared to those from the other district. Conclusion: In the population of the Tyumen North, the constant use of such water for drinking purposes can lead to the early development and rapid progression of cardiovascular and osteoarticular diseases, type 2 diabetes, neoplasms, etc.; at the same time, people are at risk of generalization of immunosuppressive conditions, diseases of the central nervous system, gastrointestinal tract, oxidative metabolism disorders, etc.
Pemberian minyak pala (Myristica fragrans) Houttuyn 1774 sebagai bahan anestesi dengan konsentrasi berbeda pada benih lobster air tawar (Cherax quadricarinatus) Von Martens 1868
Authors: Mamuko Nelsi , Mingkid Winda M. , Watung Juliaan Ch. , Kreckhoff Reni L. , Longdong Sammy N. J. , Manginsela Fransine B.
Published: March 2022

This study aimed to examine the best concentration of nutmeg oil for anesthesia of freshwater crayfish (Cherax quadricarinatus) seeds and analyze the length of time to faint, the length of time to faint and the length of time to wake up for the seeds of freshwater crayfish (C. quadricarinatus) . This research was carried out at the Aquaculture Technology Laboratory, Faculty of Fisheries and Marine Sciences, Sam Ratulangi University, Manado. The time of the research was carried out from April 18, 2021 - May 18, 2021. This study used a completely randomized design (CRD) consisting of 5 treatments and 3 replications, thus there were 15 experimental units. Treatment A with a dose of nutmeg oil (0.7 mL), treatment B (1 ml), treatment C (1.3 mL), treatment D (1.6 mL) and treatment E (1.9 mL). Parameters observed during behavioral research, length of time to faint, length of time to faint and length of time to wake up. The results of the study using the ANOVA statistical analysis test and the BNT follow-up test (Least Significant Difference) showed that different doses of nutmeg oil had a very significant effect on the length of time to faint, the length of time to faint and the length of time to wake up. The length of time to pass out the fastest, the longest length of time unconscious and conscious longest duration was obtained in treatment E (1.9 mL).
Pertumbuhan dan kelangsungan hidup ikan nila Oreochromis niloticus salin pada padat penebaran yang berbeda
Authors: Baring Vira , Longdong Sammy N. J. , Ngangi Edwin L. A. , Sinjal Hengky J. , Kalesaran Ockstan J. , Paruntu Carolus P.
Published: March 2022

This study aimed to determine the effect stocking density on growth and determine the effect on the survival of saline tilapia. The experiment was conducted at the Aquaculture Technology Laboratory and the time of the study was from February to August 2021. The experiment was designed according to a completely randomized design (CRD) with 4 treatments and 3 replications so that there were 12 experimental units. The factors tested were differences in stocking density of tilapia with treatment A: 10 fish/20 liters, treatment B: 15 fish/20 liters, treatment C: 20 fish/20 liters, and treatment D: 25 fish/20 liters. Growth data and survival rate (%) were analyzed using analysis of variance for RAL, then LSD test (Least Significance Different) was performed. Observations of water quality include temperature, DO, pH, and salinity. The result of the analysis of variance showed that the difference in stocking density had a significant effect on growth, but on the survival rate had an insignificant effect. The results of the BNT test on growth showed that treatment A was not significantly different from treatments B and C, but treatments A, B, and C were significantly different from treatment D. The temperature range during the experimental period was between 29 0C – 30.9 0C, DO ranged from 4.07 ppm – 6.80 ppm, pH between 6.78 – 7.95, and salinity 25 ppt
Identifikasi bakteri patogen Aeromonas sp. pada ikan Nila (Oreochromis niloticus) di Desa Matungkas, Kecamatan Dimembe, Kabupaten Minahasa Utara
Authors: Sinubu Wulan V. , Tumbol Reiny A. , Undap Suzanne L. , Manoppo Henky , Kreckhoff Reni L.
Published: March 2022

The purpose of this study was to identify the bacteria Aeromonas sp. in a tilapia (Oreochromis niloticus) culture pond in Matungkas Village, Dimembe District, North Minahasa Regency. Bacterial identification was carried out at the Laboratory of the Fish Quarantine Center for Quality and Safety Control of Fishery Products, Manado. The time of the study was carried out from February 2021 - June 2021. Ten samples of fish were selected from 3 existing ponds for this study with the criteria of fish that have clinical signs of disease infection such as pale body surface, red spots and ulcers. From 10 samples, 19 isolates were obtained to be identified. The bacterial method was carried out based on the results of gram tests and biochemical tests which included: Gram Tests, Motility Test, Oxidase Test, Oxidative Fermentative Test, Tolerance Test to incubation temperature, Tolerance Test to pH of the media, Tolerance Test to the concentration of NaCl in the media and rimler – shotts selective media test. Of the 19 isolates from 10 samples identified, there were 7 isolates that were positive for A. hydrophila, namely: N1.4.1, N2.1.1, N2.1.2, N2.2.1, N2.3.2, N3.3.1, and N3.3.2. Twelve other isolates were negative for A. hydrophila. The characters of A. hydrophila identified are creamy in colour, gram negative, oxidase positive, bacteria tolerance to temperature 4 °C positive, 37 °C positive, 50 °C negative, can move (motile), fermentative, pH tolerance test media pH 3 negative, pH 5 positive, pH 9 positive, pH 11 positive, tolerance test for NaCl concentration 0.5% positive, 3% positive, 5% negative, rimler – shotts positive. All sampling sites (ponds) in Matungkas Village were infected with bacteria.
Kelayakan tepung darah dalam pembuatan pakan untuk pertumbuhan ikan nila, Oreochromis niloticus)
Authors: Takou Putri D. , Mokolensang Jeffrie F. , Pangkey Hanneke , Lumenta Cyska , Manoppo Henky , Wantasen Adnan S.
Published: March 2022

The purpose of this study was to determine the feasibility of blood meal in various level inclusins in  promoting  the growth rate and nutrient utilization of O. niloticus.  The results showed that the absolute growth of tilapia in treatment 2 (with a combination of 20%) was higher than the other treatments. The daily growth rate of tilapia in treatment 2 (3.5% / day) was higher than other treatments. Likewise, with the feed change value, treatment 2 showed significantly different from other treatments. The combination of tuna fish meal waste and blood meal showed significantly different results from the results of statistical tests
Studi kualitas air di area akuakultur Desa Eris Kabupaten Minahasa
Authors: Sinaga Rohana , Undap Suzanne L. , Kusen Diane J. , Pangemanan Novie P. L. , Mudeng Joppy D. , Pangemanan Jeannette
Published: March 2022

The aim of this study was to monitor the condition of water quality in the aquaculture area of fix net cage culture system (KJT) at Lake Tondano, Eris Village, Eris District, Minahasa Regency which included temperature, pH, DO, TDS, Turbidity, NO2, NH3, PO4  and sediment (N, Nitrogen and P, Phosphorus) in  a different time. This research was conducted from March to May 2021 using a survey method. The research activities consisted of direct measurements in the field (in situ) using a Horiba U-5000G instrument and laboratory analysis (ex situ) at the BTKLPP Class 1 Laboratory and the BARISTAND Laboratory in Manado for primary data. Primary data was carried out at 3 points, Point 1 represented around residential activities, Point 2 where the areas of cultivation activities, and Point 3 where outside of cultivation and settlement activities. Primary data was compared with secondary data i.e, publish articles and then processed in the STORET method. Data were evaluated to the water quality parameters standard according to the Indonesian Government Regulation number 22 of 2021. The results showed that the water temperature ranged between 26.3 - 28.07 0C, Turbidity (10.5 - 24.4 NTU), TDS (0.167 - 0.172 g/L), pH (3.79 - 7.84), DO (1.87 - 9.05 mg/L), NH3 (0.12 - 0.26 mg/L) , NO2 (0.001 - 0.064 mg/L), PO4 (0.2 mg/L - 1.67 mg/L). In the sediment samples, N was found in the  ranged of 0.20% - 0.26% and  P (0.48% - 2.69%). It can be concluded, the condition of water quality in the aquaculture area using KJT in Eris Village is categorized as class C (medium polluted) and N in the sediment criteria is moderate and the content of P in the sediment criteria is very low.
Efisiensi usaha akuakultur sistem mina padi kolam dalam di Kabupaten Minahasa Tenggara
Authors: Toar Debby , Mudeng Joppy D. , Watung Juliaan Ch. , Longdong Sammy N. J. , Kusen Diane J. , Wantasen Adnan S.
Published: March 2022

This study aimed to evaluate the efficiency of the aquaculture system of the deep water rice field aquaculture system in Southeast Minahasa Regency. The method used was survey method with the respondents were all cultivators who carry out the deep water rice field aquaculture system. The data collected included primary and secondary data, with data collection techniques of observation, interviews and literature study. Data analysis was done by combining qualitative and quantitative analysis. Quantitative data analysis carried out were revenue, income and efficiency and business feasibility. The results showed that the production of deep water rice field aquaculture system in Southeast Minahasa Regency for fish was 24,700 kg and rice 69,300 kg. The cost incurred was Rp. 499,392,000, - with a net profit of Rp. 487,707,998,-. The efficiency of deep water rice field aquaculture system in Southeast Minahasa Regency was 1.90 which means this business was said to be efficient, while the business feasibility value was 0.90 which means to continue deep water rice field aquaculture system business was needed to be considered
¬Kajian kelayakan lokasi budidaya sidat (Anguilla spp.) di Perairan Danau Tondano, Provinsi Sulawesi Utara
Authors: Parenta Villy D. , Pangemanan Novie P. L. , Longdong Sammy N. J. , Kusen Diane J. , Salindeho Indra R. N. , Tumembouw Sipriana S.
Published: March 2022

The objective of this research was to determine feasibility ility on eel fish (Anguilla spp.) culture locations in Tondano Lake, North Sulawesi Province in terms of water quality, both physical and chemical parameters of the waters. Determination of the sampling point is placed at three predetermined points, station I located at Eris Village, Station 2 located at Paleloan Village and Station 3 located at Paslaten Village. The results showed that the waters of Lake Tondano have three classes of suitability for the location of eel (Anguilla spp.) culture, that is very suitable (S1), suitable (S2), and not suitable. Station I of Eris Village included in the suitable class (S2), Station II at Paleloan Village is included in the very appropriate very suitable class (S1), while Station III at Paslaten Village included in the class that is not suitable to be used as a location for eel culture in terms of water quality
Implementasi Sistem Perhitungan Cost Management Kontruksi Proyek Menggunakan Metode Earn Value Management (Evm) Berbasis Web
Authors: Ruseno Ndaru
Published: March 2022

Optimisasi Sistem Perhitungan Cost Management Kontruksi Proyek Menggunakan Metode Earn Value Management (EVM) memiliki tujuan untuk memudahkan perhitungan dan pengendalian biaya dari konstruksi proyek dan melihat tren data untuk mengoptimalkan biaya operasional dan strategi pertumbuhan pada perusahaan.. Metode EVM sendiri merupakan metode yang paling ideal karena metode ini dapat mengintegrasikan waktu dan biaya sehingga bisa mengetahui kemajuan suatu proyek lebih cepat atau lebih lambat dari jadwal proyek yang seharusnya dan untuk mengetahui lebih besar atau lebih kecil dari anggaran yang seharusnya. EVM menambahkan langkah-langkah yang harus dimasukkan kedalam proses manajemen yaitu pada proses pengendalian, dan proses yang berhubungan dengan tujuan untuk melakukan perhitungan, analisa, peramalan, pelaporan biaya dan performansi jadwal untuk evaluasi dan tindakan stakeholder proyek. Penelitian ini menghasilkan sebuah sistem yang mampu mengoptimisasi yang terealisasikan sebagai pendukung keputusan dalam mengoptimalkan dan mengelola atau mengendalikan suatu proyek pada perusahaan. Aplikasi ini dirancang dengan bahasa pemograman PHP dan digunakan MySQL sbg databasenya.
Penerapan Metode Simple Additive Weighting (SAW) Dalam Pemilihan Peminatan Jurusan Siswa di SMK Mandalahayu
Authors: . Satria Satria , . Rinanti , Mukiman Kikim , Mutaqin Subekti Zaenal
Published: March 2022

SMK Mandalahayu Bekasi is one of the schools in the city of Bekasi which routinely carries out the selection of majors for its students every year. The major is intended so that later students can complete school according to their interests and abilities before continuing to a higher level. The current majors selection process has drawbacks, including it takes a long time and the results obtained are less accurate because there could be many mistakes due to the unavailability of a special application to support these calculations. In addition, the element of subjectivity is quite high because the criteria used are still few and less relevant. To overcome this problem, a decision support system is made to determine the selection of majors. In this study using the Simple Additive Weighting (SAW) method. The criteria used are Mathematics SKHUN scores, Indonesian SKHUN scores, English SKHUN scores, Written Test scores and Interview Test scores. The final result of this study found that the decision support system with the SAW method was able to overcome problems in the selection process of majors at SMK Mandalahayu Bekasi. From taking a sample of several students who have been calculated using the SAW method, the correct major is AP because the value is 79, RPL because the score is between 90-100 and AK, because the score is between 80-89
Studi dan Analisis Pengembangan Smart Campus Application Framework Menggunakan Pendekatan Microservices Architectures
Authors: Jumiyani Rahil , Wisnuadhi Bambang
Published: March 2022

Abstract- A smart campus applications are a set of applications developed to support a realization of smart campus paradigm. There is a possibility of development doing regularly because business domain requirements in a university area are highly dynamic and complex. A consideration for estimated potential impacts needs to be involved for long-term goals and strategy planning to embody smart campus vision. One of those is defining appropriate system architecture. The approach of microservices architecture can be used in this development because it allows evolution activities doing continuously. The evolution activities are possible because there are business requirements changes, activity of performances and reliability improvements. A selection of architecture which is sufficient scalability requirement of smart campus application can be done by defining their characteristics, especially availability of scalability aspect. It will have an impact on efficiency cost of continuous development. This study focuses on microservices architectures as smart campus framework architecture in study case of smart campus application development in Politeknik Negeri Bandung. Abstrak- Smart campus application adalah sistem yang dibangun untuk mendukung kebutuhan smart campus.  Kebutuhan business domain di lingkungan perguruan tinggi yang sangat dinamis dan kompleks tidak menutup kemungkinan terhadap upaya pengembangan aplikasi secara berkala. Pertimbangan terhadap proyeksi potensi dampak yang akan terjadi perlu dilibatkan dalam tujuan dan perencanaan jangka panjang serta strategi dalam pengembangan aplikasi yang mendukung terwujudnya visi smart campus, salah satunya dengan mendefinisikan arsitektur sistem yang sesuai. Microservices architecture merupakan pendekatan yang dapat digunakan dalam pengembangan aplikasi yang memudahkan dilakukan kegiatan evolusi secara berkesinambungan dengan adanya perubahan business environment, peningkatan perfomansi dan reliabilitas sistem. Pemilihan arsitektur yang memenuhi kebutuhan skalabilitas smart campus applications dapat dilakukan dengan memperhatikan karakteristik yang memenuhi kriteria tertentu, khususnya konteks skalabilitas, sehingga pengembangan aplikasi dapat dilakukan dengan lebih cost efficient. Kajian ini akan berfokus pada studi kelayakan teknis microservices architecture sebagai arsitektur dasar dalam pengembangan Framework Smart Campus pada studi kasus di lingkungan Politeknik Negeri Bandung.
Pengembangan Sistem Informasi Pelayanan Pelanggan Berbasis Web pada CV. Perum Jasa Tirta II
Authors: Husin Ishak , Subekti Zaenal Mutaqin , Rahayu Ratna Rahmawati , Nurjannah Daka Nanda
Published: March 2022

Pandemi covid 19 menyebabkan beberapa perusahaan menjadi turun pendapatan nya, seperti pada Perum Jasa Tirta II menjadi kehilangan beberapa pelanggan sebagai dampak akibat dari Covid-19 yang mulai melanda indonesia pada bulan maret tahun 2020, ditambah dengan Belum adanya sistem informasi yang saling terintegrasi antara divisi Usaha dan divisi keuangan dengan pelanggan, ini menjadi solusi sebagai salah satu upaya pelayanan prima kepada pelanggan dalam proses bisnis di Perum Jasa Tirta II. rancang bangun sistem informasi pelayanan pelanggan berbasis web agar dapat mempermudah pelayanan pelanggan pada Perum Jasa Tirta II. Adanya sistem informasi pelayanan pelanggan berbasis web dimaksudkan agar dapat diakses tanpa batas waktu dan tempat tertentu. Penelitian ini menggunakan framework Codeigniter dan database mysql dengan menggunakan tahapan penelitian analisa kebutuhan, desain, implementasi dan pengujian. Dalam pengujian menggunakan pendekatan blackbox yang menghasilkan dari testing halaman registrasi, halaman login dan beberapa menu pada sistem informasi pelayanan pelanggan perum jasa tirta II dapat berjalan dengan baik.
Cultural Problems Require Cultural Solutions: Partnership between Anthropology and the U.S. Marine Corps to Prevent Suicide
Authors: Allard Seth
Published: March 2022

The U.S. military continues to experience high and increasing rates of suicide despite massive funding and support for research and prevention. The dominant research and prevention paradigm, which is strongly oriented toward quantitative, clinical, psychodynamic, and biomedical approaches, can greatly improve with an expansion into qualitative, ethnographic methods, theories, and applications. Critical discussion of key aspects of military suicide research and prevention and the nature of anthropological research support a robust partnership between the discipline of anthropology and the U.S. Marine Corps to address and prevent suicide.
POTENTIAL ANTI-BACTERIAL POWDER BOOTING WATER, n-HEXANA EXTRACT AND EARTHWORM CHLOROFORM EXTRACT (Peryonix sp.) AGAINST Salmonella typhosa BACTERIA
Authors: Indriana Meutia , Salman Salman
Published: March 2022

Earthworms are animals that have many benefits and are easy to find—results of information from people consume boiled water of earthworms three times a day for 7 days is used as a typhus medicine, other information is obtained from electronic media, many people also consume earthworms as a typhoid medicine in powder form which is filled into capsules Which can be found in Chinese drug stores, but until now scientific research on earthworms (Perionyx sp.) as an anti-bacterial has not been done. Extraction is done by maceration. Multilevel maceration using chloroform and n-hexane as solvent. The class of chemical compounds was determined on the ethyl acetate extract and the n-hexane extract of the earthworm Perionyx sp.), including alkaloids, glycosides, steroids/triterpenoids, flavonoids, saponins, and tannins. Testing of antibacterial activity of chloroform extract and n-hexane extract against Salmonella typhosa was carried out in vitro by agar diffusion method using metal buffer at a concentration of 500 mg/ml; 400 mg/ml; 300 mg/ml; 200 mg/ml; 100 mg/ml and 50 mg/ml. The results of determining the class of chemical compounds from the chloroform extract of earthworms (Perionyx sp.) showed the presence of chemical compounds belonging to the alkaloid group, while the n-hexane extract did not indicate the presence of chemical compounds detected. The n-hexane extract of tar h (Perionyx sp.) had an inhibitory effect on the growth of Salmonella typhosa at a minimum inhibitory concentration of 400 mg/ml of 10.9mm, while the chloroform extract had a minimum inhibitory concentration of 300 mg/ml with an inhibitory diameter of 12.87 mm.
Idealização e implantação dos cursos de comunicação visual e desenho industrial da UFPR
Authors: De Oliveira Alexandre Antonio , Oliveira Corrêa Ronaldo
Published: March 2022

Este artigo trata da concepção e implementação dos cursos de Comunicação Visual e Desenho Industrial da Universidade Federal do Paraná (UFPR) por meio de levantamento de fontes documentais. Busca-se traçar uma conjuntura sócio histórica da cidade de Curitiba, assim como as particularidades institucionais que viabilizaram a criação dos cursos. Além do levantamento bibliográfico, foram utilizados documentos como atas de reuniões, grades curriculares, cartas e resoluções. Também foram coletados depoimentos de diversos personagens que fizeram parte do início deste curso, tanto docentes quanto discentes. Descreve-se, primeiramente, as teorias e paradigmas que permeavam o ensino do design no Brasil nas décadas de 1960 e 1970. Traça-se um panorama social, econômico e cultural de Curitiba nessas décadas e então narra-se os episódios para a idealização e implantação dos cursos, focando nos relatos dos entrevistados e em documentos da instituição.
Contribuições para aumentar o potencial econômico-financeiro em projetos de produtos e serviços baseados em design thinking
Authors: Silva Pinto Marcelo , Machado Rocha Alexandre , Copola Azenha Flávio , Delage e Silva Gabriel , Leme Fleury André
Published: March 2022

Projetos baseados em design thinking ganharam muito espaço no âmbito da gestão e desenvolvimento de projetos visando inovação. Muitos negócios incorporaram a abordagem, porém não está consolidado o fato de que o processo é passível para desenvolvimento de produtos e serviços que realmente gerem captação de valor para os negócios. Por isso, o trabalho apresentado buscou compreender como se dá o processo de capitação de valor em projetos baseados em design thinking por meio de uma ampla revisão de literatura e estudos de dez casos. A pesquisa identificou lacunas na literatura  e descobertas nos estudos de caso que contribuem para o desenvolvimento da teoria e prática sobre o tema. Os resultados podem contribuir ainda, para gestores e empreendedores dialogarem de maneira mais eficiente com designers e projetistas, possibilitando assim, projetos alinhados com as expectativas dos envolvidos, aumentando a captação de valor nos projetos.
The biomechanical characteristics of spinal dura mater in the context of its basic morphology
Authors: Szotek Sylwia , Dawidowicz Joanna , Geniusz Malwina , Kozak Marta , Łukomski Robert , Czogalla Aleksander
Published: March 2022

Purpose: Spinal dura mater plays a crucial role in the biomechanics and protection of the spine. Therefore, the present study investigated the dura mater's mechanical and basic morphological properties to learn more about the biomechanical behaviour of this fibrous membrane. Methods: Tissue strips, oriented in the longitudinal and circumferential directions, were cut from the cervical, thoracic, and lumbar vertebrae parts of the porcine spinal cord. Uniaxial tensile tests were performed using a device with a speed of 4 mm/min until rupture of the sample. Results: It was demonstrated that the dura mater is a heterogeneous, anisotropic material. The longitudinal excised specimens showed the highest values of mechanical properties (ultimate force (FU), the stiffness coefficient (k), ultimate tensile strength (σUTS), and Young’s modulus (E)) compared to those of the circumferentially. Confocal microscopy and sulforhodamine B (SRB) assay enabled us to visualise collagen and elastin elements more efficiently without a need for sample fixation. Conclusions: The spinal dura mater mechanical properties are not uniform along the entire length of the spinal cord, but, in the case of morphological features, no major differences were noticed. The utilisation of SRB occurred to be a non-destructive, fast, and efficient tool for visualising even the smallest elastic fibres on different depths of examined samples. The mechanical and morphological properties of the dura mater provided by this study can be further used in computational modelling to understand injury mechanisms better and help develop injury prevention strategies.
Changes in muscle length and orientation after orthognathic surgeries using a bilateral sagittal split osteotomy as an example
Authors: Pachnicz Dominik , Stróżyk Przemysław , Grygier Dominika
Published: March 2022

Purpose: The aim of the present study was to analyze the changes in the angular positions and lengths of the mandibular elevator muscles due to the displacement of bone segments after bilateral sagittal split osteotomy. Additionally, the impact of changes in mandibular geometry on the values of occlusal forces and mandibular condyle loading was considered. The combined geometric and force analysis makes a valuable contribution to the operating conditions of the system affected by the changes. Methods: The considerations were based on elementary principles of analytical geometry and the analysis was performed for two craniofacial geometries. Results: For the rotation of the proximal segment, the greatest differences in angular position concern the masseter muscle during roll rotation (11.7). Significant changes in muscle length occurred during pitch rotation and amounted to 3.7 mm. Translation of the distal segment by 10 mm changed the angle of the pterygoid muscle by 30.2 in the coronal plane and 18.7 in the sagittal plane, simultaneously changing its direction to that of the opposite. Posterior translation (10 mm) caused an elongation of the muscle by 4.7 mm and anterior translation caused a shortening by 2.6 mm. For the mandible with elongated geometry, lower values of occlusion forces and increased reaction forces in the condyle were observed. Conclusions: The analysis revealed significant changes in the orientation and length of the masticatory muscles, and thus, their potential impact on the functioning conditions of the masticatory system.
University Students’ Readiness for Online Learning in the Context of Emergency Remote Learning: A Comparison of Students’ Preparedness and Lecturers’ Views
Authors: George Lois , Gay Glenda H.E. , Cook Loraine D. , Moore Schontal
Published: March 2022

Due to concerns related to the increasing spread of the coronavirus (COVID-19), from March 2020, traditional face-to-face classes at all educational levels in Jamaica were replaced with online teaching and learning. This convergent mixed methods study compared university students’ reported readiness for engaging in online learning within this context, with lecturers’ views of the challenges that students experienced with the transition to emergency remote learning. Quantitative data were collected from 132 university students in one department using an online survey, while qualitative data were collected from nineteen lecturers who taught a total of forty courses within the same department using a questionnaire that was disseminated via email. One key finding is that most students reported being technologically prepared, but exhibited poor technical aptitude, online study skills and weak online learning lifestyles that are required for engaging in online learning. This finding was corroborated by lecturers who also noted that some students appeared to be unfamiliar with technology tools. The findings suggest that instruction should be organized in ways that accommodate students’ technical challenges. However, it is imperative that there is shared collaboration and a community endeavour to improve students’ technical aptitude, study habits and learning lifestyle for improved online learning readiness.
Selection of putative relic cacao (Theobroma cacao L.) genotypes in farmers' fields in Trinidad and Tobago
Authors: Maharaj Kamaldeo
Published: March 2022

Trinidad and Tobago is a repository of putative relic cacao genotypes, given its long history of cultivating cacao from the 1700s onwards. As part of a project conducted between 2009 and 2011, funded by the World Bank Development Market Place, World Bank Project TF 093747 (DM 2008), 106 putative, ancient cacao varieties were collected from farms throughout Trinidad and Tobago to be conserved and utilized to preserve traditional quality (flavour) attributes. The objective of this article is to provide information on agronomic and phenotypic traits of 94 of these 'relic' accessions collected in farmers' fields (FA). These are presumed to be relic Criollos or Trinitarios (selected pre-and post-1930s), and were selected over six cocoa production zones in Trinidad and Tobago. In addition, data for 31 regional Trinitario cacao accessions, which are conserved at the International Cocoa Genebank Trinidad (ICGT) were assessed. Morphological assessment of the selections was based on 22 phenotypic traits including characteristics of economic interest, viz. bean number (BN), individual dried bean weight (DBW), total wet bean weight (TWBW) and pod index (PI), which ranged from 26.4 to 58.0 (CV 16.3%); 0.6g to 2.12g (CV 22.6%); 42.5 to 228g (CV 24.2%) and 10 to 57 (CV 27.5%), respectively. Significant differences (p < 0.0001) were found among the production zones for BN and DBW only. Four zones had selections with significantly higher BN and all six had selections with superior TWBW relative to the ICGT clones studied. No association between cotyledon colour and leaf petiole hairiness was found, suggesting independent inheritance of these traits used for preliminary identification of 'Criollo-like' genotypes in the field. FAs from Tobago generally had selections with paler cotyledons, implying relatively more pronounced Criollo ancestry. Principal Component (PC) scores 1 and 2 accounted for 74.7% of the phenotypic variation expressed by the accessions studied in terms of five traits, based on Principal Component Analysis (PCA). PI and TWBW were major contributors to PC 1, while for PC 2, the major contributors were BN and DBW. The results of PCA and cluster analyses suggest that a phenotypically diverse and unique selection of genotypes was collected from the farmers' fields, relative to studied ICGT types, several of which displayed 'Criollo-like' and Trinitario characteristics (large, plump seeds/beans with pale cotyledons) and favourable yield potential. These can be utilized to enhance the genepool at the ICGT, for breeding to introgress favourable Trinitario genes into national recurrent breeding programmes and for commercial cultivation.
The Effect of Multilevel Doses of Caffeine on Tissue Macrophage and Blood Lymphocyte Count in Autologous Full Thickness Skin Graft Healing in Sprague Dawley Rats
Authors: Prabowo Wahyu Haris , Awal Prasetyo  , Neni Susilaningsih
Published: March 2022

Backgrounds. A skin graft is one of the routine surgical procedures performed. This procedure gives excellent results when done as early as possible after the trauma. Caffeine has a mechanism as an adenosine-receptor A2 antagonist which can induce wound healing through increased angiogenesis. This study aimed to determine the efficacy of coffee caffeine in the initiation of full thickness skin graft autologous wound healing by assessing the number of macrophages and lymphocytes in Sprague-Dawley rats.

Methods. The research design is an experimental study with a post-test-only approach with a control group design. Twenty male Sprague Dawley rats aged 15 weeks (140 – 150 grams) were randomly divided into four groups. One group became the control group (decaffeinated) while the other group received various doses of caffeine (3 mg/kgBW, 6 mg/kgBW, and 9 mg/kgBW). Autologous skin grafts were performed in all groups. HE examination was performed to confirm the number of macrophage cells in the tissue. Data analysis was carried out with the help of SPSS 25 software.

Results. There were significant differences in the number of tissue macrophages in the four groups. The group that received 9 mg/kgBW of caffeine showed the highest number of macrophages compared to the other groups. Based on the number of lymphocytes in the peripheral blood, the group that received a dose of 6 mg/kg BW showed the highest number of lymphocytes compared to other groups.

Conclusion. Caffeine showed the ability to initiate full thickness skin graft autologous wound healing by increasing the number of macrophages and lymphocytes in Sprague Dawley rats.
Urgensi Pembaharuan Regulasi Pendirian Rumah Ibadah Di Indonesia
Authors: Steven Albert , Gumansalangi Aprilo Gerald , Prasetiyawati Yusiana Eka
Published: March 2022

Kehidupan beragama di Indonesia seringkali disorot. Sebabnya, seringkali terjadi polemik terkait pendirian rumah ibadah. Adanya Peraturan Bersama 2 Menteri yang mengatur perizinan pendirian rumah ibadah menuai kritik dari pihak-pihak yang merasa dirugikan. Peraturan Bersama 2 Menteri dianggap melanggar hak konstitusional warga negara untuk beribadah. Di sisi lain, pendirian rumah ibadah di Indonesia merupakan hal yang sensitif bagi beberapa pihak karena agama tidak lepas dari unsur politis. Oleh karena itu perlu adanya kajian tentang urgensi adanya pengaturan pendirian rumah ibadah di Indonesia. Jika dilihat dari perspektif hak konstitusional, maka seharusnya pengaturan pendirian rumah ibadah di Indonesia tidak melanggar prinsip nondiskriminasi.
Keadilan Transisional Sebagai Upaya Penyelesaian Pelanggaran Berat Hak Asasi Manusia Di Indonesia
Authors: Winandi Woro
Published: March 2022

Grave violations human rights (human rights) which occurred in authoritarian countries pose victims of serious violations of human rights. As a result, during the transition from an authoritarian regime to a democratic regime came the serious human rights violations settlement demands voiced by victims of serious human rights violations and their heirs. Similar conditions also occur in Indonesia, which was once ruled by authoritarian regimes that use repressive laws to keep themselves in power in the period 1966-1998. Along reformasi in 1998, there was a period of transition in Indonesia, which brings the impact of reforms in all areas, including judicial reform.
Mendudukkan Lingkup Pemantauan Dan Evaluasi Peraturan Daerah Oleh Dewan Perwakilan Daerah
Authors: Rahmawan Triya Indra
Published: March 2022

Upon the enactment of Law No 2 in 2018, the Regional Representative Council has been given a new authority and task to monitor and evaluate the Local Regulations. The establishment of the new authority and task has provided a challenge for the Regional Representative Council in determining the scope of monitoring and evaluation. Overlap of functions might occur because the central government is also responsible for supervising the Local Regulations. Therefore, the Regional Representative Council should be able to spot the differences in the Local Regulations supervised by the legislative or executive councils. To avoid overlapping authorities, the monitoring and evaluation scope should be focused on formulating problems that are faced by the local government in planning, preparing, and implementing the Local Regulations. These results will, thus, be established in a form of a policy recommendation for preparing materials contained in a local autonomy law.
Tanggung Gugat Dokter Atas Kelalaiannya Dalam Menyampaikan Informed Conset Dan Hasil Operasi Yang Tidak Sesuai Dengan Keinginan Pasien
Authors: Santoso Bezaleel Nugara
Published: March 2022

The society is not only an object of healt enforcement, but also a subject. Therefore, the enforcement of health services is a joint responsibility of the health care providers and the health care recipients. In the application of the profession, a doctor cannot be separated from the health law. However, it is important to acknowledge that a doctor is a common human being who can also make mistakes or commit malpractice in doing his job. A doctor can be hold responsible on the criminal law, civil law, and administrative law. In civil law, a doctor can be hold responsible based on a law violating act and breach of contract. Breach of contract happens when one of the party does not perform what is promised, perform what is promised later than it is supposed to be, perform what is promised below the expectation promised. Meanwhile, an action is considered violating the law when it fulfills the four criteria such as the existence of an action againt the law, there must be a mistake, there must be a loss/damage caused by the action, and there must be a causal relation between the action and the loss/damage. A law violating act does not only mean violating the regulations, but also failing to do the law obligation of the perpetrator, violating other people’s subjective rights, violating the ethics, and violating decency, accuracy and circumspection.