bluuebunny/crossref_metadata_2025 huggingface dataset:
Interposition Arthroplasty for Chronic Proximal Humerus Osteomyelitis
Authors: Nahy Emilio , Velasquez Garcia Ausberto
Published: February 2023

Case:

Two years after a right shoulder arthroscopic procedure, a 49-year-old woman presented with significant dysfunction and pain to our orthopaedic department. Laboratory and imaging evaluation demonstrated chronic glenohumeral osteomyelitis with irreparable damage to the humeral articular surface. A 2-stage soft-tissue shoulder interposition arthroplasty was performed to rebalance the joint. Long-term follow-up revealed functional results with pain control and no reinfection.

Conclusion:

For patients at high risk of reinfection or unable to undergo prosthetic joint implantation, this approach may be considered a functional alternative to salvage procedures.
“Flipped Lid” Fracture of the Lateral Tibial Plateau with Dislocated Lateral Meniscus
Authors: Kambhampati Srinivas B.S. , Chodavarapu Mounika N.S. , Kambhampati Anirudh P.S. , Chittoor Sai Prasad , Chinta Shyam Kumar
Published: February 2023

Case:

We present a rare “flipped lid” type of fracture of the lateral tibial plateau with dislocation of the lateral meniscus into the notch with intact roots. This was fixed using headless screws through arthrotomy and peripheral suturing of the meniscus. At the 1-year follow-up, although there was terminal restriction of 10° flexion with redislocation of the lateral meniscus, the patient was able to perform all daily activities and declined further surgery.

Conclusion:

Flipped lid–type fracture is rare and results in good outcome when fixed early. Meniscal dislocation repair requires close monitoring to detect failure.
Entropi-ARAS Yaklaşımıyla Kripto Para Yatırım Alternatiflerinin Değerlendirilmesi
Authors: BULDUK Seher , ECER Fatih
Published: February 2023

2009 yılında piyasaya giriş yapan kripto paralar, âdemi merkeziyetçi bir yapıda mübadele işlevini yerine getiren sanal para birimleridir. Kripto paralar, blockchain teknolojisine bağlı olarak ticari işlemlere konu olması ve düşük transfer maliyeti ile hızlı işlemler gerçekleştirilmesi gibi niteliksel özelliklere sahiptir. Kripto paralar, bir yatırım aracı olarak son yıllarda büyük ilgi görmektedir. Bu çalışmanın temel amacı, yatırımcıların yatırım kararı vermesini kolaylaştıracak bir karar destek mekanizması sunmaktır. Bu amaçla Entropi-ARAS çok kriterli modeli kullanılarak finansal piyasalarda en yüksek işlem hacmine sahip ilk on kripto para değerlendirilmiştir. Öncelikle Entropi yöntemi kullanılarak yıllık ortalama getiri, işlem hacmi, toplam piyasa değeri, işlem gördüğü borsa sayısı, işlem gördüğü yıl sayısı, işlem hızı, en yüksek değerden değişim ve volatilite kriterinin ağırlıkları belirlenmiştir. Ardından ARAS yönteminde kullanılarak, kripto para alternatiflerinin performans sıralaması yapılmıştır. Çalışmanın bulgularına göre, işlem hacmi yatırım yaparken dikkate alınması gereken en önemli faktördür. Ayrıca, alternatif kripto paralar içinde ilk sırada Bitcoin, Tether ve Usd Coin yer alırken, Dogecoin son sırada yer almaktadır. Kripto paraların işlem hacmi ile performans sıralamalarının yüksek derecede pozitif korelasyona sahip olduğu sonucuna da ulaşılmıştır. Son olarak önerilen modelin sağlamlığı ve geçerliliği duyarlılık analiziyle de kontrol edilmiştir.
Spor Yönetiminde Kriz İletişimi: İmaj Tamir Teorisi ve Durumsal Kriz İletişim Teorisi
Authors: ÖRS Şerife
Published: February 2023

Krizler örgütlerce yaygın olarak değerli bir kaynak olarak kabul edilen kurumsal itibara zarar verici tehdit unsurlarıdır. Kurumsal itibar paydaşlar ve onların algıları ve atıfları ile şekillendiğinden kriz yönetiminde gerçekleştirilecek iletişim faaliyetlerinin önemi son derece büyüktür. Bu doğrultuda, çalışmanın amacı kriz iletişimi literatüründe önce çıkan Bill Benoit'in (1995) İmaj Tamir Teorisi ve Timothy Coombs’un (1995) Durumsal Kriz İletişim Teorisi’ni spor alanında ele almaktır. Öncelikle kriz yönetimi ve iletişimi ile ilgili kavramsal çerçeve çizilmiş, araştırmaya temel alınan ilgili teoriler ve varsayımları açıklanmış, sonrasında ise uluslararası ve ulusal spor literatüründe gerçekleştirilen çalışmalar değerlendirilerek kuramların alana katkıları ortaya konmuştur. Sonuç olarak yazınımızda ilgili teoriler çerçevesinde gerçekleştirilen çalışmaların oldukça sınırlı olduğu tespit edilmiş ve gerek vaka analizi gerekse deneysel tasarım çalışmaların alana katkılar sağlayacağı öngörülmüştür.
Marka Deneyiminin Müşteri Sadakati Yaratmadaki Rolü: Otel İşletmeleri Örneği
Authors: ASI Büşra , ÖZDEMİR Şefika
Published: February 2023

Müşteriler ürünlerin kendilerine sağlayacağı işlevlerden daha çok deneyimlerden elde edebilecekleri kişisel ve sembolik yararlar ile işletmelerin kendileri için hazırladıkları çekici ve özel deneyimlerle ilgilenmektedir. İşletmeler ise müşteri sadakati yaratmak için müşterilerin duygularını harekete geçirmeyi hedefleyerek, onların yaşam tarzları ile bütünleşmeyi amaçlayan marka deneyimi oluşturmaktadır. Otel işletmeleri rakiplerinden farklılaşmak için marka deneyimi oluşturmaya daha fazla önem vermektedir. İşletmeler müşteri sadakati yaratmak, sürdürmek ve müşterilerle yakın ilişkiler kurarak bağ oluşturmak için olumlu tutumlar oluşturacak deneyimler tasarlamaktadır. Sadık müşteriler oluşturan işletme, müşterilerinin olumlu düşünceleri sonucu çevrelerine işletme hakkında referans vermesi ile reklamlarını müşterileri aracılığıyla yapmaktadır. Bu araştırma, marka deneyiminin ve boyutlarının müşteri sadakati yaratmadaki rolünü incelemeyi amaçlamıştır. Bu bağlamda Isparta ilindeki 4 ve 5 yıldızlı otel işletmelerinde konaklayan 381 kişiye yüz yüze anket gerçekleştirilmiştir. Anketlerden elde edilen verilere SPSS 22.0 programında doğrusal regresyon analizi ve varyans analizi ile test edilmiştir. Araştırma bulgularına göre marka deneyimi ve müşteri sadakati arasında pozitif yönlü güçlü bir korelasyon bulunmuştur. Marka deneyiminin düşünsel boyutunun, duyusal boyutunun ve duygusal boyutunun müşteri sadakati üzerinde anlamlı bir etkisinin olduğu belirlenmiştir. Marka deneyiminin duygusal boyutu ve müşteri sadakati arasında pozitif yönlü güçlü bir korelasyon bulunmuştur. Sonuç olarak marka deneyiminin, müşteri ve işletme arasındaki ilişkinin devamlılığının sağlanmasında önemli bir role sahip olduğu anlaşılmaktadır.
Katılım Bankası Çalışanlarının Öznel İyi Oluş Düzeylerinin Farklı Demografik Değişkenler Açısından İncelenmesi
Authors: OKUDUR SABUNCU Betül , ÇARIKÇI İlker Hüseyin
Published: February 2023

Bu araştırma banka çalışanlarının işyerindeki öznel iyi oluş (mutluluk) düzeylerinin farklı demografik değişkenler (yaş, medeni ve eğitim durumu, cinsiyet ve çalışılan pozisyon) açısından farklılaşma durumunu ortaya koymayı hedeflemektedir. Araştırma, bir katılım bankasının Türkiye’de faaliyet gösteren tüm şube çalışanlarını kapsamaktadır. Çalışmada online anket tekniğinden yararlanılmış, 15.04.2021-19 tarih ve sayılı Süleyman Demirel Üniversitesi etik kurul izni ile kolayda örnekleme yöntemi kullanılarak veriler toplanmıştır. Ölçüm aracı olarak Lyubomirsky ve Lepper (1999)’ın geliştirdiği, Akın ve Satıcı (2011)’nın Türkçe uyarlamasını yaptığı ölçek kullanılmıştır. Araştırma kapsamında 1100 banka çalışanına ulaşılmış, 374 kişi ankete katılım sağlamıştır. Toplanan verilerin analizinde SPSS 26.0 programından yararlanılmıştır. Araştırmada frekans analizleri, ölçeklere ait güvenilirlik analizi ile katılımcıların öznel iyi oluşlarının demografik değişkenlere göre farklılaşma durumlarını belirlemek amacıyla bağımsız örneklem t-testi ve anova testi kullanılmıştır. Araştırmanın bulgularına göre, katılım bankası çalışanlarının genel öznel iyi oluş (mutluluk) seviyesi orta düzeyin üzerindedir. Katılımcıların öznel iyi olma durumları medeni duruma göre farklılaşmaktadır. Evli olan katılım bankası çalışanlarının evli olmayanlara göre öznel mutluluk düzeyinin daha yüksek olduğu sonucuna ulaşılmıştır. Katılımcıların cinsiyet, yaş, eğitim durumu ve çalışılan pozisyona göre öznel iyi oluş düzeyleri farklılaşmamaktadır. Elde edilen sonuçlar önceki çalışmaların bulguları ile birlikte tartışılmıştır.
Research and Application of a Controllable Permeability Refracturing Technology in a High-Water-Cut Potential Layer
Authors: Qi M. , Yang E. , Liu Y. , Dong C. , Chen X.
Published: February 2023

The Fuyu oil field is a typical shallow, low-temperature, low-permeability reservoir. At present, the oilfield composite water cut is 95%, artificial fractures interlace with natural fractures, and the distribution of ineffective circulation channels between wells is complex. This paper found that after reducing the permeability of the original fracture, refracturing can effectively improve the longitudinal extension range of the new fracture through numerical simulation. Therefore, a controllable permeability temporary plugging agent is studied, and controllable permeability refracture technology is proposed. The controllable permeability temporary plugging system is composed of elastic particles, quartz sand, and quick-soluble elastic enhancers, which are based on elastic particles that do not age, and long-term plugging can be achieved. Through physical experiments, 0.5–1-mm elastic particles with 70–140 mesh and 16–30 mesh quartz sand were used in different ratios (i.e., 5:5, 6:4, and 7:3). According to the closure pressure and the permeability of the fracturing layer, the ratio chart of elastic particles and quartz sand is established. The controllable permeability refracture technology can select the ratio of the quartz sand and elastic particles according to the closure pressure and the control requirements of the fracturing horizon permeability. Through field applications, we found that, compared with the conventional refracturing technology, the average daily fluid gain per well decreased from 5.0 to 3.9 tons, and the daily oil gain increased from 0.3 to 0.6 tons. The controllable permeability fracturing technology could reduce the permeability of the original fracture and improve the vertical production degree of the reservoir after refracturing. In addition, this method ensures that the original fracture has a certain conductivity and that the high-permeability layer reserves are not lost due to temporary plugging agents, thus expanding the planar sweep volume and effectively improving reservoir recovery. Nevertheless, the chart established is mainly suitable for shallow reservoirs, and the closure pressure is 3–15 MPa in this paper. Further testing and research are needed for deep reservoirs.
Investigation of petrophysical and hydrogeological parameters of the transboundary Nubian aquifer by combining geophysical and hydrogeological methods: a case study of Khartoum state, Sudan
Authors: Mohammed Musaab Adam Abbakar , Szabó Norbert P. , Szűcs Péter
Published: February 2023

This research follows an integrated approach for delineating subsurface lithology and estimating petrophysical and hydrogeological parameters of the Cretaceous Nubian formation aquifer in Khartoum state, Sudan. The Nubian aquifer is a fossilized transboundary regional aquifer that covers more than a quarter of the Sudan’s area. The integrated approach includes geophysical well-logging, surface geophysical electrical methods, and pumping data analysis. Geophysical well-logs, including self-potential (SP), natural gamma ray (GR), and long normal resistivity (RS) for with the aid of described lithological logs are employed to delineate the transboundary Nubian aquifer, and the obtained results are extrapolated by vertical electrical sounding (VES) and boreholes lithological logs. As a result, two aquifers are detected. An upper aquifer of an average thickness of 50 m and a lower aquifer of more than 200 m. These two aquifers are hydraulically connected under semi-confined to confined conditions. Consequently, areal variation maps of depth to aquifers and resistivity are prepared to avoid wells constructions failures. For a thorough evaluation of the aquifers, in the first stage, the petrophysical and hydrogeological parameters, including formation factor, total and effective porosity, shale volume, and hydraulic conductivity, are measured solely from geophysical well-logs with the aid of hydrochemical data. In the second step, the results of geophysical well-logs are interpolated and generalized to detect the spatial variation of the measured petrophysical and hydrogeological parameters over the study area. This was achieved by combining VES measurements and pumping test data with the geophysical well logs. The applied scheme minimized the expenses and effort of the global hydrogeological survey by improving the spatial coverage of the detected parameters. The measured petrophysical and hydrogeological parameters revealed that this formation is highly productive and ideal for groundwater development. However, optimizing groundwater discharge rates is recommended for sustainable water supply in Khartoum state.
Application of Artificial Intelligence Techniques for Predicting the Back-break in Blasting Operation
Authors: Sorabi Parviz , Ataei Mohammad , Jazi Mohammad Reza Alimoradi , Dehghani Hesam , Shakeri Jamshid , Habibi Mohammad Hosein
Published: February 2023

One of the adverse consequences of the blasting in the mineral extraction process in mines is back-break (BB) so that development of many fractures and cracks at large distances behind the last row of blast pits reduces the safety of the benches and increases operating costs. Since various parameters affect the BB, various techniques have been developed to predict and optimize its values. In this study, 48 blasts were investigated in Gol Gohar Mine No. 1 in the tailings section of the mine to predict BB based on the Whale Optimization Algorithm (WOA), Multiverse Optimizer (MVO), Sine Cosine Algorithm (SCA), and Ant Lion Optimizer (ALO). The parameters of bench height, hole length, burden, spacing, specific charge, the number of blasting rows, hole diameter, stemming, uniaxial compressive strength, joint spacing, and geological strength index (GSI) were evaluated as inputs to the models to predict back-breaks in the blasts. The comparison of the results of four BB prediction models suggested that the MVO-based model with a coefficient of determination (R2) of 0.9802, root-mean-square error (RMSE) of 0.2161, and mean squared error (MSE) of 0.1127 had the highest accuracy and the lowest error. So, it was introduced as the most appropriate model for predicting BB.
Widespread Pain Phenotypes Impact Treatment Efficacy Results in Randomized Clinical Trials for Interstitial Cystitis/ Bladder Pain Syndrome: A MAPP Network Study
Authors: Farrar John , Locke Kenneth , Clemens J , Griffith James , Harte Steven , Kirkali Ziya , Kreder Karl , Krieger John , Lai H. Henry , Moldwin Robert , Mullins Chris , Naliboff Bruce , Pontari Michel , Rodríguez Larissa , Schaeffer Anthony , Stephens-Shields Alisa , Sutcliffe Siobhan , Taple Bayley , Williams David , Landis J
Published: February 2023

Clinical trials of pain are notoriously difficult and inefficient in demonstrating efficacy even for known efficacious treatments. Determining the appropriate pain phenotype to study can be problematic. Recent work has identified the extend of widespread pain as an important factor in the likelihood of response to therapy, but has not been tested in clinical trials. Using data from three previously published negative studies of the treatment of interstitial cystitis/ bladder pain with data on the extent of widespread pain, we examined the response of patients to different therapies base on the amount of pain beyond the pelvis. Participants with predominately local but not widespread pain responded to therapy targeting local symptoms. Participants with widespread and local pain responded to therapy targeting widespread pain. Differentiating patients with and without widespread pain phenotypes may be a key feature of designing future pain clinical trials to demonstrate treatments that are effective versus not.
Preliminary study for counting fossil diatoms using a deep learning system: An approach to automated estimation of a paleoenvironmental index
Authors: Ishino Saki , Itaki Takuya , Hisada Daichi , Taira Yousuke
Published: February 2023

Two types (intercalary and terminal) of valves of Eucampia antarctica, a species of diatom, have shown potential as paleoenvironmental tools in the Southern Ocean. Taxonomists have counted the valves manually; however, they have required considerable time to assess the relationship between the ratio of the valves and environmental factors. Here, we present an end-to-end automatic approach for counting E. antarctica using the microfossil classification and rapid accumulation device (miCRAD) system, which enables model classification while acquiring microscopic images. We constructed a deep learning-based model for identifying the intercalary and terminal valves of E༎antarctica in a diatom assemblage. Additionally, we tested whether the constructed model functions as a manual count using an experimental image dataset containing all particle images acquired during the whole-scanning of permanent slides. Following cross-validation to verify the model performance potential, the model accuracy reached 0.92 with the use of the training images. The proportion of intercalary valves to all E. antarctica valves (i.e., a total of terminal and intercalary valves) calculated from the model counts yielded 0.55 on average, showing a + 0.05% difference against the actual value of 0.50. However, using the experimental dataset, the model classifications performed worse than the ones estimated based on the cross-validation. The lower performance was attributed to the imbalanced class dataset from the whole-scanning of permanent slides, which includes many other particles. This experiment demonstrated that the classification model constructed with miCRAD system has comparable performance in predicting E.antarctica valves to manual counting; however, screening images before the classification step will be necessary to completely automate the classification.
Characterisation of monoclonal antibodies against porcine epidemic diarrhea virus S1/S2 junction protein.
Authors: Huang Nan , Lang Qiaoli , Li Liping , Ge Liangpeng , Yang Xi
Published: February 2023

Pig producers have suffered serious economic losses from porcine epidemic diarrhea virus (PEDV) infection. Development of PEDV antibodies for detection or treatment has become an important research direction.The S1/S2 junction (S1S2J) cleavage site of S protein of PEDV is one of the major determinants of coronavirus infection success. In this study, we specifically selected the S1S2J protein of PEDV-AJ1102 (a representative strain of the G2 type) as target protein to immunise mice and generated monoclonal antibodies (mAbs) using hybridoma technology. Three mAbs showed high-binding activity to the S1S2J protein were further analysed. To reveal the characterisation of mAbs, variable region genes of antibodies were studied by using DNA sequencing, which revealed differences in their CDR3 amino acid sequences. We then developed a new method to identify the isotypes of these three mAbs. Results showed that these three antibodies were of the IgM type. As for the functions of these three mAbs, indirect immunofluorescence assay confirmed their good binding ability to Vero E6 cells infected with PEDV-SP-C strain (G1 type). Epitope analysis showed linear epitopes for all three mAbs. These antibodies were also used to detect infected cells via flow cytometry analysis. In summary, we have prepared and examined three mAbs against PEDV-S1S2J. The focal antibodies can be employed as detection antibodies for diagnostic reagents and further developed for other applications. We also designed a novel technique for easy and cost-saving identification of isotypes of mouse mAbs. Our results lay a good foundation for the development of research for PEDV.
Effect of percutaneous transluminal angioplasty and stenting vs aggressive medical management on Risk of Stroke and Death in Patients with stroke or intracranial atherosclerotic stenosis: a systematic review and meta-analysis
Authors: Lai Zhiyu , Peng Mingqiang , Li Yingbin , Bai Xiaoxin , cai jun
Published: February 2023

Background: There are currently two treatment strategies mainly for high-risk patients: percutaneous transluminal angioplasty and stenting (PTAS) and aggressive medical management (AMM). However, the choice between PTAS or AMM remains controversial for patients with stroke or intracranial atherosclerotic stenosis (ICAS).
Methods: The investigators searched PubMed, Web of Science, Embase, Scopus, and Cochrane library databases. Randomized controlled trial (RCT) comparing the PTAS and AMM for patients with stroke or ICAS were selected. RevMan 5.3 was used to analyze the results and risk of bias. The primary endpoints are stroke and death within 30 days after enrollment, or ischemic stroke in the territory of the qualifying artery beyond 30 days, and entire follow-up endpoints. The secondary outcomes were the disabling or fatal stroke, and incidence of death within 3 years.
Results: Four studies, 989 patients were included in this article. The AMM group was superior in the entire follow-up endpoint (OR: 0.56; 95% CI: 0.40, 0.79). The AMM also better in primary endpoint within 30 days (OR: 0.32; 95% CI: 0.17, 0.61). There was no significant difference beyond 30 days (OR: 1.08; 95% CI: 0.63, 1.86). The remaining outcomes, such as stroke and death, were not significantly different (P>0.05).
Conclusion: This meta-analysis shows AMM is significantly more effective than PTAS in subjects with ICAS because of the high rate of periprocedural OR: 0.32; 95% CI: 0.17, 0.61) and entire follow-up (OR: 0.56; 95% CI: 0.40, 0.79) stroke from PTAS and the fact that PTAS offers no benefit over AMM beyond 30 days (OR: 1.08; 95% CI: 0.63, 1.86).
Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: Clinical efficacy and correlative analyses
Authors: Konopleva Marina , DiNardo Courtney , Bhagat Tushar , Baran Natalia , Lodi Alessia , Saxena Kapil , Cai Tianyu , Su Xiaoping , Skwarska Anna , Guerra Veronica , Kuruvilla Vinitha , Konoplev Sergej , Gordon-Mitchell Shanisha , Pradhan Kith , Aluri Srinivas , Collins Meghan , Sweeney Shannon , Busquet Jonathan , Rathore Atul , Deng Qing , Green Michael , Grant Steven , Demo Susan , Choudhary Gaurav , Sahu Srabani , Agarwal Beamon , Spodek Mason , Thiruthuvanathan Victor , Will Britta , Steidl Ulrich , Tippett George , Burger Jan , Borthakur Gautam , Jabbour Elias , Pemmaraju Naveen , Kadia Tapan , Kornblau Steven , Daver Naval , Naqvi Kiran , Short Nicholas , Garcia-Manero Guillermo , Tiziani Stefano , Verma Amit
Published: February 2023

Malignancies can become reliant on glutamine as an alternative energy source and as a facilitator of aberrant DNA methylation, thus implicating glutaminase (GLS) as a potential therapeutic target. We demonstrate preclinical synergy of telaglenastat (CB-839), a selective GLS inhibitor, when combined with azacytidine (AZA), in vitro and in vivo, followed by a phase Ib/II study of the combination in patients with advanced MDS. Treatment with telaglenastat/AZA led to an ORR of 70% with CR/mCRs in 53% patients and a median overall survival of 11.6 months. scRNAseq and flow cytometry demonstrated a myeloid differentiation program at the stem cell level in clinical responders. Expression of non-canonical glutamine transporter, SLC38A1, was found to be overexpressed in MDS stem cells; was associated with clinical responses to telaglenastat/AZA and predictive of worse prognosis in a large MDS cohort. These data demonstrate the safety and efficacy of a combined metabolic and epigenetic approach in MDS.
An Assessment of the Move Your Way Program Among Hispanic Adults in Las Vegas, Nevada
Authors: Bungum Timothy , Pharr Jennifer , Coughenour Courtney , Gakh Maxim
Published: February 2023

Background
Physical activity (PA) is important because of its associated health benefits. However, many Americans remain inactive. The federal government first adopted PA guidelines in 2008 and revised them in 2018. The 2018 guidelines recognize that PA bouts of less than 10 minutes are beneficial. The U.S. Department of Health and Human Services’ Office of Disease Prevention and Health Promotion created the Move Your Way® (MYW) campaign to provide PA resources for communities and healthcare providers. This study aims to describe the reach of the MYW campaign, and assess whether having seen, heard, or read (SHR) about MYW, or having seen the MYW logo, was associated with PA knowledge and self-efficacy, and PA behavior among Hispanics residing in the Las Vegas area. Methods: Hispanics, aged 18–74, were surveyed at community events (n = 481) or via an online survey (n = 123). Respondents were asked if they had SHR of MYW, were aware of 2018 PA recommendations and reported their personal PA behavior, PA knowledge, PA intentions, and demographics. Results: Respondents (71% female) completed a 38-42-item survey. Approximately (12.4%) had SHR of the MYW campaign and 16.1% had seen the MYW logo. Only 3.4% and 15% correctly identified, “150 minutes per week” and “75 minutes per week” as the 2018 guidelines for moderate physical activity (MPA) and vigorous physical activity (VPA), respectively. Those who had SHR of the MYW campaign were more likely to correctly identify 150 minutes per week as the MPA guideline and had greater confidence in overcoming selected PA barriers. Those who had seen the MYW logo were more apt to meet strength guidelines. Conclusions: Knowledge of the MYW program positively associates with some PA behaviors and PA correlates.
Gait Generation of Hexapod Robot for the CPG Controller by Using the Delayed Van der Pol Oscillators
Authors: Song Zigen , Zhu Jiayi , Xu Jian
Published: February 2023

In this study, we construct a type of CPG (central pattern generator) controller by using the delay-coupling Van der Pol (VDP) oscillators and propose an analysis method of parameter modulation to illustrate the locomotion gait of a hexapod robot. The structure topology of the CPG controller is scheduled as a unidirectional ring network consisting of six identical units. Each unit has independentparameters to modulate amplitude and frequency of the period activity. Employing the Hopf bifurcation, we first propose parameter conditions to guarantee the existence of the period activity for the delayed CPG controller, where coupling delay can induce generation and extinction of the period activity. Due to the symmetry structure of the proposed CPG controller, the period activity induced by coupling delay presents multiple spatiotemporal patterns with a constant phase difference. Based on theoretical analysis of the equivariant Hopf bifurcation, we further pinpoint parameter regions for the corresponding spatiotemporal patterns. Then using the invariable phase difference between signal outputs of the VDP oscillators, we assign connection order of the CPG units to link the hexapod’s legs and produce the hexapodal locomotion gaits. The results show that the coupling delay in the delayed VDP-CPG controller is an effective method to obtain many types of the hexapodal locomotion gaits.
Complete Chloroplast genomes of five Cuscuta species and their evolutionary significance in the Cuscuta genus
Authors: Pan Hangkai , Zagorchev Lyuben , Chen Luxi , Tao Yutian , Cai Chaonan , Jiang Ming , Sun Zhongshuai , Li Junmin
Published: February 2023

Background
Cuscuta, a parasitic plant species in the Convolvulaceae family, grows in many countries and regions. However, the relationship between some species is still unclear. Therefore, more studies are needed to assess the variation of the chloroplast genome in Cuscuta species and their relationship with subgenera or sections, thus, providing important information on the evolution of Cuscuta species.
Results
In the present study, we identified the whole chloroplast genomes of C. epithymum, C. europaea, C. gronovii, C. chinensis and C. japonica, and then constructed a phylogenetic tree of 23 Cuscuta species based on the genome sequences. We also compared the number of genes and the structure of chloroplast genome and the patterns of gene reduction. Most chloroplast genomes of Cuscuta spp. have tetragonal and circular structures except for C. epithymum, C. europaea, C. pedicellata and C. approximata. Moreover, a simple sequence repeat analysis showed that the Cuscuta chloroplast genome is species-specific. The inverted repeat boundaries of the four regions between different subgenera were similar. Gene rearrangement showed that different Cuscuta species in the same subgenus have similar chloroplast genome structures. Several chloroplast genes were lost. In addition, the numbers and types of the lost genes in the same subgenus were similar. Most of the lost genes were related to photosynthesis (ndh, rpo, psa, psb, pet, and rbcL). Thus, they could have gradually caused the plants to lose the ability to photosynthesize.
Conclusion
Our results enrich the data on cp genomes of genus Cuscuta. This study provides new insights into understanding the phylogenetic relationships and variations in the chloroplast genome of Cuscuta species.
Bioavailability of bioactive phytochemicals in selected tissues and excreta from goats fed hempseed cake (Cannabis sativa L.) finisher diets
Authors: Semwogerere Farouk , Chikwanha Obert C. , Katiyatiya Chenaimoyo L. F. , Marufu Munyaradzi C. , Mapiye Cletos
Published: February 2023

Hempseeds are rich in bioactive phytochemicals, yet little is known about their bioavailability in tissues and excreta of animals fed hemp seed cake. The study evaluated the bioactive phytochemicals and their antioxidant activity in blood, liver, meat, feces and urine from goats fed finishing diets containing graded inclusions of hempseed cake (HSC). Twenty-five wether goats (27 ± 3 kg) of 4-5 months were randomly allocated to five experimental diets containing increasing levels of HSC (0, 25, 50, 75, 100 g/kg DM) substituted for soybean meal (SBM) as the main protein source. Goats were adapted for 21 days, and blood, fecal and urine samples collected on day 28. The liver and right longissimus thoracis et lumborum were respectively collected 60 min and 24 h after slaughter. Linear increases (P ≤ 0.05) in blood, liver and urine magnesium, fecal manganese, and fecal copper were observed with increasing HSC inclusion in the diet. Liver and fecal selenium exhibited a decreasing linear trend (P ≤ 0.05) with HSC increment in diets. Diet did not affect (P > 0.05) meat and urine mineral contents, except urine magnesium. The 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid; ABTS) of blood, liver, and meat linearly increased (P ≤ 0.05) with dietary inclusion of HSC. Blood and liver ferric reducing antioxidant power (FRAP) quadratically increased (P ≤ 0.05) with HSC inclusion reaching a maximum at 50 g/kg DM. Current results suggest that inclusion of HSC up to 100 g/kg substituting SBM in goat diets can improve bioavailability of bioactive phytochemicals in blood, liver, and meat.
Two Novel Lytic Bacteriophages having Therapeutic Potential against MDR Avian Pathogenic Escherichia coli strains of zoonotic potential
Authors: Sattar Sadia , Bailie Marc , Yaqoob Akasha , Khanum Sofia , Fatima Kaniz , Altaf Anees Ur Rehman Bin , Ahmed Ibrar , Shah Syed Tahir Abbas , Munawar Javeria , Zehra Quaratul Ain , Daud Sajeela , Arshad Ayesha , Imdad Kaleem , Javed Sundus , Tariq Amira , Bostan Nazish , Altermann Eric
Published: February 2023

Avian pathogenic E. coli (APEC) is associated with local and systemic infections in poultry, ducks turkeys and many other avian species which leads to heavy economical losses. These APEC strains are presumed to possess zoonotic potential due to common virulence markers that can cause urinary tract infections in humans. The prophylactic use of antibiotics in poultry sector has led to rapid emergence of Multiple Drug Resistant (MDR) APEC strains that also put human populations at risk acting as reservoirs. This calls for consideration of alternative strategies for their treatment such as phage therapy. Here, we report isolation, characterization, and genome analysis of two novel lytic phage species (Escherichia phage SKA49 and Escherichia phage SKA64) against MDR strain of APEC, QZJM25. Both phages were able to keep QZJM25 growth significantly less than bacterial control for approximately 18 hours. Host range was tested against Escherichia coli strains of poultry and human UTI infections. SKA49 had broader host range contrast to SKA64. Both phages were stable at 37°C only. Their genome analysis indicated their safety as no recombination, integration and host virulence genes were identified. Based on this analysis both these phages can be used as effective biocontrol agents in poultry industry.
Design of computer big data processing system based on genetic algorithm
Authors: Chen Song
Published: February 2023

In recent years, people have witnessed the rapid growth of data, and big data has penetrated into every aspect of people's lives. If a big data processing system wants to extract the hidden value behind massive data, it is inseparable from the support of a large number of underlying infrastructure resources. However, the one-time expensive investment in the initial economy and the complexity of the later work of operation and maintenance hinder the use of some small and medium-sized enterprises. Based on this background, with the continuous development of computer technology, this paper constructs a large-scale data processing system that introduces genetic algorithms, making full use of the advantages of on-demand self-service and the elastic expansion of computer technology, shortening the time required for data processing and data analysis. life cycle, so that more and more enterprises and organizations can start using big data processing technology. For fragmented big data obtained from different data sources, this paper adopts load balancing technology to provide horizontal service cluster scalability, and designs a separate system module for routine testing. The experimental results show that the designed function of the system can be realized, and the actual error is always lower than the specified error limit. It is hoped that the research work in this paper can provide useful reference and help for the design of computer big data processing system. This paper designs a kind of effective big data processing system by studying genetic algorithm and computer technology.
Delayed vascular complication after collagenase injection for Dupuytren disease
Authors: Nordenskjöld Jesper , Nilsson Jonas , Kalaf Roua , Atroshi Isam
Published: February 2023

Background
Vascular adverse events after collagenase injection for Dupuytren disease are absent in large trials and systematic reviews. The aim of this study is to present a case series of delayed vascular complications after collagenase treatment.
Methods
A prospective evaluation of 1181 consecutively treated patients at one orthopedic department identified three patients reporting symptoms of possible vascular complication. Baseline demographics and description of symptoms were collected, with a physical examination documenting extension deficit and neurovascular status. All patients completed the Cold Intolerance Symptom Severity (CISS) scale (range 4-100, lower is better) and underwent Doppler sonography examination of the digital arteries.
Results
All patients were treated in the small finger and two had an isolated proximal interphalangeal joint contracture. All patients had a delayed presentation of a few months, with episodes of white discoloration of the treated finger relieved within 30 minutes and associated with variable pain, paresthesia, stiffness and weakness. Two of the patients reported cold exposure as an episode trigger and had a pathological CISS score (40 and 36, respectively). Doppler sonography identified a nonpatent ulnar digital artery in one patient.
Conclusions
Delayed vascular complication after collagenase treatment is rare, but surgeons and patients should be aware of the risk, especially when treating the small finger.
Distributed adaptive PI consensus tracking control for output-constrained nonlinear multiagent systems with unknown control directions
Authors: Zhu Lingchen , Zhang Liuliu , Hua Changchun
Published: February 2023

This paper investigates the problem of distributed adaptive PI consensus tracking control for output-constrained nonlinear multiagent systems (MASs) with unknown control directions and unknown time-varying actuator faults under the directed graph. Firstly, an auxiliary filter network is constructed to estimate the output of the leader. Then, by introducing a nonlinear state transformation function, the asymmetric constraints on agents' outputs can be achieved with unconstrained initial conditions. Furthermore, based on the Nussbaum-type functions, a distributed adaptive PI controller is designed by utilizing the constructed generalized error for nonlinear MASs with unknown time-varying control directions caused by actuator faults. It is proved that the proposed control scheme can guarantee that all signals in the closed-loop system are bounded and the distributed asymptotic consensus tracking is achieved. Finally, a simulation example illustrates the effectiveness of the proposed control strategy.
The structural components of the Azotobacter vinelandii iron-only nitrogenase, AnfDKG, form a protein complex within the plant mitochondrial matrix
Authors: Johnston Ema , Okada Shoko , Gregg Christina , Warden Andrew , Rolland Vivien , Gillespie Vanessa , Byrne Keren , Colgrave Michelle , Eamens Andy , Allen Robert Silas , Wood Craig
Published: February 2023

A long-held goal of synthetic biology has been the transfer of a bacterial nitrogen-fixation pathway into plants to reduce the use of chemical fertiliser on crops such as rice, wheat and maize. There are three classes of bacterial nitrogenases, named after their unique metalloclusters containing either Mo-, V- or Fe, that convert N2 gas to ammonia. Relative to the Mo-nitrogenase the Fe-nitrogenase is not as efficient for catalysis but has less complex genetic and metallocluster requirements, features that may be preferable for engineering into crops. Here we report the successful targeting of bacterial Fe-nitrogenase proteins, AnfD, AnfK, AnfG and AnfH, to plant mitochondria. When expressed as a single protein AnfD was mostly insoluble in plant mitochondria, but coexpression of AnfD with AnfK greatly improved its solubility. Using affinity-based purification of mitochondrially expressed AnfK or AnfG we were able to demonstrate a strong interaction of AnfD with AnfK and a weaker interaction of AnfG with AnfDK. This work establishes that the structural components of the Fe-nitrogenase can be engineered into plant mitochondria and form a complex, which will be a requirement for function. This report outlines the first use of Fe-nitrogenase genes within a plant as a preliminary step towards engineering an alternative nitrogenase into crops.
The difference between two brachycephalic and one mesocephalic dog breeds' problem-solving performance suggests evidence for paedomorphism in behaviour
Authors: Ujfalussy Dorottya , Bognár Zsófia , Molnár Marianna , Miklósi Ádám , Kubiniy Enikő
Published: February 2023

Despite the serious problems with their general health and longevity, small brachycephalic breeds, especially the French bulldog, are becoming increasingly popular among pet owners. The motivations for the choice of short-nosed breeds have been extensively investigated in recent years; however, this issue has been addressed mainly by relying on owner reports, resulting in somewhat vague explanations of "cute looks", referring to the child-schema phenomenon and "behaviour well suited for companionship".
In this study, we set out to compare the behaviour of two brachycephalic (English and French bulldogs) and a mesocephalic (Hungarian mudi) breed in a problem-solving context. The dogs were given the task of opening boxes containing food rewards. We investigated human-directed behaviour elements over success and latency (indicators of motivation and ability).
...
We found that the short-headed breeds were less successful but much more oriented toward humans than mesocephalic dogs. Owners might interpret these behaviours as "helplessness" and dependence. The results support the hypothesis that infant-like traits may be present not only in appearance but also in behaviour in brachycephalic breeds, eliciting a caring behaviour in owners.
Simulation of agricultural digital economy development and policy support system based on resource sensitivity index
Authors: Dai Yanqing
Published: February 2023

The development of science and technology has also led to the progress of rural digital economy. In China, the construction of new countryside has always been an important part of economic development. The application of big data technology in rural areas can not only promote the development of rural economy, but also improve the results of environmental protection. Using the matching coefficient method of agricultural water and soil environmental characteristics, it match the rural water and soil environmental characteristics and the impact of the water environment in the autonomous region.An indispensable driving force in the process, agricultural digitalization will update the rural economic development model, weaken the barriers to the dual structure of urban and rural areas, stabilize agricultural production, promote sustainable rural development, and promote rural economic development. The current government policy support, the urgent need for new development momentum for rural economic development, and the advancement of changes in the lifestyle of urban and rural residents are promoting high-quality development of the rural economy. At the same time, we are facing challenges such as the lack of local network coverage, the lack of logistics, sales systems, and the lack of talents with digital skills. Expanding rural network coverage, optimizing rural logistics and distribution, promoting the development of agricultural big data, and strengthening the development of digital human resources are important ways for agricultural digitalization to promote rural economic development. The research focus of this paper is the parallel development of rural digital economy and environmental protection under the big data economy, and its application in the current agricultural development can achieve a win-win situation between man and nature.
Application of machine learning based BIM in green public building design
Authors: Wang Dan , Chang Fuhua
Published: February 2023

Public activities are mostly carried out in large public buildings, which are closely related to social management. At present, people's demand for public building facilities is increasing, its shape evolution is becoming more complex, and the scientific and technological content of construction related technology is also increasing. The development trend of green public buildings is more and more strong. The traditional building design can not effectively deal with the energy consumption of public buildings and people's demand for their performance. This paper introduces BIM and machine learning technology to study their practical application in the design of green public buildings, and tests the perfect machine learning algorithm. According to the experimental test results, the building energy consumption decreased by 14.3%, the carbon emission decreased by 11.39%, and the absolute value of PMV thermal comfort decreased by 34.7%, which obviously achieved the optimization effect. BIM Technology parametric design can enable the design model formed by conceptual design research to automatically draw construction drawings, detailed drawings and other drawings according to the drawing requirements and standards, thus saving the designer's time and enabling him to transfer the drawing time to the program design. Finally, through experiments, the economy, rationality and operability of using BIM Technology to design green public buildings are confirmed. In this paper, machine learning and BIM Technology are introduced, so as to carry out design research for green public buildings design.
Child_Sum EATree-LSTMs: Enhanced Attentive Child_Sum Tree-LSTMs for Biomedical Event Extraction
Authors: Wang Lei , Cao Han , Yuan Liu , Guo Xiaoxu , Cui Yachao
Published: February 2023

Background
The tree-structured neural network can deeply extract lexical representations of sentence syntactic structure. Some studies have utilized Recursive Neural Network to detect event triggers.
Methods
We incorporate the attention mechanism into Child-Sum Tree-LSTMs for the task of biomedical event triggers. Based on the previous research, we incorporated attention mechanism into Child-Sum Tree-LSTMs to assign an attention weight for the adjacent nodes to detect the biomedical event trigger words. The existing shallow syntactic dependencies in Child-Sum Tree-LSTMs ignore the deep syntactic dependencies. To enhance the effect of attention mechanism, we integrate the enhanced attention mechanism into the Child-Sum Tree-LSTMs model using the deep syntactic dependencies.
Results
Our proposed model integrating an enhanced the attention mechanism in Tree-LSTM on MLEE and BioNLP’09 both show best performance. The model also achieves the better performance on almost all of the complex event categories on the test set of BioNLP’09/11/13.
Conclusion
We evaluate the model performance on the MLEE and BioNLP datasets, and the experimental results demonstrate the advantage of enhanced attention to detect biomedical event trigger words.
The dicot homolog of maize PPR103 carries a C-terminal DYW domain and is required for C-to-U editing of chloroplast RNA transcripts
Authors: McCray Tyra , Azim Mohammad , Burch-Smith Tessa
Published: February 2023

In plants, cytidine-to-uridine (C-to-U) editing is a crucial step in processing mitochondria and chloroplast-encoded transcripts. This editing requires nuclear-encoded proteins including members of the pentatricopeptide (PPR) family, especially PLS-type proteins carrying the DYW domain. IPI1/emb175/PPR103 is a nuclear gene encoding a PLS-type PPR protein essential for survival in Arabidopsis thaliana and maize. Arabidopsis IPI1 was identified as likely interacting with ISE2, a chloroplast-localized RNA helicase associated with C-to-U RNA editing in Arabidopsis and maize. Notably, while the Arabidopsis and Nicotiana IPI1 homologs possess complete DYW motifs at their C-termini, the maize homolog, ZmPPR103, lacks this triplet of residues which are essential for editing. We examined the function of ISE2 and IPI1 in chloroplast RNA processing in N. benthamiana. A combination of deep sequencing and Sanger sequencing revealed C-to-U editing at 41 sites in 18 transcripts, with 34 sites conserved in the closely related N. tabacum. Virus induced gene silencing of NbISE2 or NbIPI1 led to defective C-to-U revealed that they have overlapping roles at editing a site in the rpoB transcript but have distinct roles in editing other transcripts. This finding contrasts with maize ppr103 mutants that showed no defects in editing. The results indicate that NbISE2 and NbIPI1 are important for C-to-U editing in N. benthamiana chloroplasts, and they may function in a complex to edit specific sites while having antagonistic effects on editing others. That NbIPI1, carrying a DYW domain, is involved in organelle C-to-U RNA editing supports previous work showing that this domain catalyzes RNA editing.