bluuebunny/crossref_metadata_2025 huggingface dataset:
Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature review
Authors: Calcaterra Valeria , Cavalli Riccardo , Croci Giorgio A. , Fiori Laura , Fabiano Antonella , Lunardon Luisa , Avanzini Maria Antonietta , Berti Emilio , Zuccotti Gianvincenzo
Published: October 2022

Background

Lymphomatoid papulosis (LyP) is a rare condition in pediatrics; LyP histological type D has been reported in only 7 children. The differential diagnosis of LyP in the spectrum of lymphoid proliferation remains controversial.

Case presentation

A 6-year-old boy presented to Emergency Department with a 3-week history of an erythematous papulo-vesicular itchy eruption over the submandibular regions, trunk and extremities. History, symptoms and laboratory tests were unremarkable. SARS-CoV-2 antigen was negative. The clinical suspicion of pityriasis lichenoides et varioliformis acuta (PLEVA) was posed, and topical steroids were introduced. One week after, he returned with an extensive painful scaly papulo-erythematous rash, with some ulcerated and necrotic lesions, and fever; therefore the child was hospitalized. Biochemical results were within reference limits, except for high level of C-reactive protein, aspartate aminotransferase, alanine transaminase and bilirubin. Due to a persistently high fever, systemic corticosteroid treatment was administered, with a good clinical response and an improvement of the skin lesions. Anti-PVB-19 Immunoglobulin M was detected. Elevated levels of IL-6, IL-10 and IFN-γ were also recorded. Five days post-admission, most of the lesions had cleared, and the child was discharged. Methotrexate was started, with a positive response. At skin biopsy a “PLEVA-like” pattern was apparent, with a dense, wedge shaped lymphoid infiltrate featuring epidermotropism and morphologically comprising pleomorphic and blastic cells. The pattern of infiltration was highlighted by immunohistochemical stains, which prove the process to feature a CD8+/CD30 + phenotype, the latter being intense on larger cells, with antigenic loss. Polymerase chain reaction for T-cell receptor gamma (TCRG) chain clonality assessment documented a monoclonal peak. A diagnosis of LyP type D was favored.

Conclusion

The reported case encompasses most of the critical features of two separated entities—PLEVA and LyP—thus providing further support to the concept of them representing declinations within a sole spectrum of disease. Studying the role of infectious agents as trigger potential in lymphoproliferative cutaneous disorders and detecting novel markers of disease, such as cytokines, could have a crucial impact on pathogenic disease mechanisms and perspective therapies.
Cloning and characterization of thermophilic endoglucanase and its application in the transformation of ginsenosides
Authors: Zheng Fei , Zhao Huanxi , Wang Nan , Zhong Peng , Zhou Kailu , Yu Shanshan
Published: October 2022

A novel endoglucanase (BcelFp) was identified from Fervidobaterium pennivorans DSM9078 which had biotransformation activity for protopanaxadiol (PPD)-type ginsenosides. Sequence analysis of BcelFp revealed that it could be classified into glycoside hydrolase family 5 (GH5). The gene encoding a 323-amino acid protein was cloned and expressed in Escherichia coli. The recombinant enzyme was purified, and its molecular weight was approximate 37 kDa. The recombinant BcelFp exhibited an optimal activity at 95 oC and pH 5.5 and showed high thermostability. The endoglucanase had high selectivity for cleaving the outer glucose moiety at the C3 carbon of ginsenoside Rb1, Rb2, Rc and Rd, which produced stronger pharmacologically active gypenoside XVII (GypXVII), Compound O (CO), Compound Mc1 (CMc1) and F2, respectively. The Km values for Rb1, Rb2, Rc and Rd were 3.66 ± 0.04 µM, 4.02 ± 0.12 µM, 5.95 ± 0.03 µM, 0.67 ± 0.006 µM, respectively. The kcat/Km value of BcelFp for ginsenoside Rd was 27.91 mM-1s-1, which was much higher than that of the previously enzymes. This study was the first report of the highly efficient and selective transformation of GypXVII, CO, CMc1 and F2 from Rb1, Rb2, Rc and Rd by a GH5-family thermophilic endoglucanase.
Improvements for pedestrian safety application P-Minder
Authors: Sun Chang
Published: October 2022

P-Minder is a lightweight sidewalk segmentation and obstacle detection-based approach designed for phubbers’ safety, which can help phubbers to avoid obstacles and other dangers during phubbing walking. But two issues have been found in previous experiments: P-Minder undifferentiated scores the recognition results and costs high resource occupation during background operation. Therefore, this paper proposes the sector correlation model to classify the recognition and segmentation results for an accurate judgment. Then, the new application architecture design and walking detection model decrease the resource occupation. Besides, the datasets are expanded, and the models are retrained to adapt to the improved architecture. In the same datasets, P-Minder achieves a 1.7 percentage point accuracy improvement during the experiment. The experimental result proves that the segmentation model can reach 81.2% mean intersection over union. Besides, the method finally achieves 75.52% detection accuracy in the experiment with a low computing resources cost.
An efficient computation of discrete orthogonal moments for bio-signals reconstruction
Authors: Fathi Islam S. , Ahmed Mohamed Ali , Makhlouf M. A.
Published: October 2022

Bio-signals are extensively used in diagnosing many diseases in wearable devices. In signal processing, signal reconstruction is one of the essential applications. Discrete orthogonal moments (DOMs) are effective analysis tools for signals that can extract digital information without redundancy. The propagation of numerical errors is a significant challenge for the computation of DOMs at high orders. This problem damages the orthogonality property of these moments, which restricts the ability to recover the signal's distinct and unique components with no redundant information. This paper proposes a stable computation of DOMs based on QR decomposition methods: the Gram–Schmidt, Householder, and Given Rotations methods. It also presents a comparative study on the performance of the types of moments: Tchebichef, Krawtchouk, Charlier, Hahn, and Meixner moments. The proposed algorithm's evaluation is done using the MIT-BIH arrhythmia dataset in terms of mean square error and peak signal to noise ratio. The results demonstrate the superiority of the proposed method in computing DOMs, especially at high moment orders. Moreover, the results indicate that the Householder method outperforms Gram–Schmidt and Given Rotations methods in execution time and reconstruction quality. The comparative results show that Tchebichef, Krawtchouk, and Charlier moments have superior reconstruction quality than Hahn and Meixner moments, and Tchebichef generally has the highest performance in signal reconstruction.
Oral anticoagulants: a systematic overview of reviews on efficacy and safety, genotyping, self-monitoring, and stakeholder experiences
Authors: Khouja Claire , Brunton Ginny , Richardson Michelle , Stokes Gillian , Blanchard Laurence , Burchett Helen , Khatwa Meena , Walker Ruth , Wright Kath , Sowden Amanda , Thomas James
Published: October 2022

Background

This systematic overview was commissioned by England’s Department of Health and Social Care (DHSC) to assess the evidence on direct (previously ‘novel’) oral anticoagulants (OACs), compared with usual care, in adults, to prevent stroke related to atrial fibrillation (AF), and to prevent and treat venous thromboembolism (VTE). Specifically, to assess efficacy and safety, genotyping, self-monitoring, and patient and clinician experiences of OACs.

Methods

We searched MEDLINE, Embase, ASSIA, and CINAHL, in October, 2017, updated in November 2021. We included systematic reviews, published from 2014, in English, assessing OACs, in adults. We rated review quality using AMSTAR2 or the JBI checklist. Two reviewers extracted and synthesised the main findings from the included reviews.

Results

We included 49 systematic reviews; one evaluated efficacy, safety, and cost-effectiveness, 17 assessed genotyping, 23 self-monitoring or adherence, and 15 experiences (seven assessed two topics). Generally, the direct OACs, particularly apixaban (5 mg twice daily), were more effective and safer than warfarin in preventing AF-related stroke. For VTE, there was little evidence of differences in efficacy between direct OACs and low-molecular-weight heparin (prevention), warfarin (treatment), and warfarin or aspirin (secondary prevention). The evidence suggested that some direct OACs may reduce the risk of bleeding, compared with warfarin. One review of genotype-guided warfarin dosing assessed AF patients; no significant differences in stroke prevention were reported. Education about OACs, in patients with AF, could improve adherence. Pharmacist management of coagulation may be better than primary care management. Patients were more adherent to direct OACs than warfarin. Drug efficacy was highly valued by patients and most clinicians, followed by safety. No other factors consistently affected patients’ choice of anticoagulant and adherence to treatment. Patients were more satisfied with direct OACs than warfarin.

Conclusions

For stroke prevention in AF, direct OACs seem to be more effective and safer than usual care, and apixaban (5 mg twice daily) had the best profile. For VTE, there was no strong evidence that direct OACs were better than usual care. Education and pharmacist management could improve coagulation control. Both clinicians and patients rated efficacy and safety as the most important factors in managing AF and VTE.

Systematic review registration

PROSPERO CRD42017084263—one deviation; efficacy and safety were from one review.
What evidence exists for the use of urban forest management in nature-based carbon solutions and bird conservation. A systematic map protocol
Authors: Hutt-Taylor Kayleigh , Ziter Carly D. , Frei Barbara
Published: October 2022

Background

There is global interest in finding innovative solutions that address current climate and societal challenges in an urban context. Cities are often on the front lines of environmental change, meaning urban greening strategies have high potential to provide benefits across human communities, while protecting global biodiversity. There is growing consensus that nature-based solutions can provide multiple benefits to people and nature while also mitigating the effects of climate change. Urban forest management is well-suited to a nature-based solutions framework due to the wide variety of services trees provide our communities. Effective approaches to urban forest management also have the potential to promote other forms of urban biodiversity, particularly birds and species at risk. However, studies that integrate strategies for both climate and biodiversity conservation are rare. The goal of this systematic map is to gather and describe information on two desired outcomes of urban forest management: (1) conserving avian diversity and species at risk (2) carbon storage and sequestration (i.e., nature-based climate solutions).

Methods

We will identify relevant articles from two separate searches for inclusion in our systematic map that address (1) urban forestry and avian and species at risk conservation and, (2) urban forestry and carbon storage and sequestration. We will search two bibliographic databases, consult 20 relevant organizational websites, and solicit grey literature through an open call for evidence. Eligibility screening will be conducted at two stages: (1) title and abstract and (2) full text. Relevant information from included papers will be extracted and entered in a searchable, coded database. Synthesis of evidence will describe the key characteristics of each study (e.g., geographic locations, interventions, outcomes, species studied) and identify knowledge gaps and clusters of evidence. Our systematic map will guide further research on opportunities for multiple benefits using nature-based solutions, particularly as they relate to urban forest management. Furthermore, our evidence base will support both management and funding decisions to ensure the effective use of resources for maximum benefits across people and ecosystems.
Risk factors for air leakage during invasive mechanical ventilation in pediatric intensive care units
Authors: Ma Ling , Yin Miao , Yang Xi-Lun , Xu Wei
Published: October 2022

Purpose

This study aimed to investigate air leakage during invasive mechanical ventilation (IMV) in a pediatric intensive care unit (PICU) and explore potential risk factors.

Methods

We conducted a retrospective cohort study of children who underwent IMV in a single-center PICU in a tertiary referral hospital. Air leakage risk factors and factors associated with an improved outcome were assessed.

Results

A total of 548 children who underwent IMV were enrolled in this study. Air leakage occurred in 7.5% (41/548) of the cases in the PICU. Air leakage increased the duration of IMV and hospitalization time. Multivariate logistic regression analysis showed a higher risk of air leakage during IMV for PICU patients with acute respiratory dyspnea syndrome (ARDS) (OR = 4.38), a higher pediatric critical illness score (PCIS) (OR = 1.08), or a higher peak inspiratory pressure (PIP) (OR = 1.08), whereas the risk was lower for patients with central respiratory failure (OR = 0.14). The logistic model had excellent predictive power for air leakage, with an area under the curve of 0.883 and tenfold cross-validation. Patients aged between 1 and 6 years who were diagnosed with measles or pneumonia and had a low positive end-expiratory pressure (PEEP) or high PaO2/FiO2 ratio were associated with improved outcomes. Patients diagnosed with central respiratory failure or congenital heart diseases were associated with less desirable outcomes.

Conclusions

Patients with ARDS, a higher PCIS at admission or a higher PIP were at higher risk of air leakage.
Quantify soil erosion and sediment export in response to land use/cover change in the Suha watershed, northwestern highlands of Ethiopia: implications for watershed management
Authors: Yeneneh Nigussie , Elias Eyasu , Feyisa Gudina Legese
Published: October 2022

Soil erosion accelerated by human activities is a critical challenge affecting soil health, agricultural productivity, food security and environmental sustainability in the highlands of Ethiopia. The aim of this study was to examine the dynamics of soil loss and sediment yield potential, and identify soil erosion hotspots using RUSLE with GIS in the Suha watershed, north western highlands of Ethiopia. Digital Elevation Model, LU/LC, rainfall, soil, and conservation practice were used as input data for RUSLE model. The estimated total annual soil loss for the entire watershed increased from 1.22 million tons in 1985 to 2.43 million tons in 2019, with average annual soil loss rates of 15.2 t ha−1 yr−1and 31.4 t ha−1 yr−1respectively. Total sediment yield also increased from 317.52 to 630.85 thousand tons over the past 35 years. In addition, the area of soil erosion hotspots changed from 15.2% (12,708 ha) to 32% (25,660 ha) during the same periods. Sub watershed 1, 2, 15, 17, 18, and 23 are severely degraded parts of the watershed. Expansion of agriculture and bare land as the expenses of other land use types over the past 35 years could be the major causes of extensive soil erosion risk in the watershed. Besides its temporal variability, soil loss and sediment export also showed variation between land use/cover classes. The estimated results of soil loss and sediment yield as well as soil erosion hotspots revealed that the soil erosion risk is progressively increasing during the study periods. Unless action is taken and the current condition is reversed, it will critically threat the livelihoods of the community in the watershed. Generally, the results underscore urgent demand for integrated and effective watershed management strategies.
The immunometabolic landscape of the bone marrow microenvironment in acute myeloid leukemia
Authors: Xu Binyan , Zhou Ziying , Wen Yueting , Li Zhongwei , Huang Zhongxi , Li Yuhua
Published: October 2022

The bone marrow microenvironment of acute myeloid leukemia (AML) consists of various cell types and signaling factors, which serve as a niche supporting leukemia cells in their invasion of the human body. However, a systematic landscape of metabolic heterogeneity and its relationship with immunity in the AML microenvironment at single-cell resolution has not yet been established. Herein, we addressed this issue by analyzing 208,543 bone marrow cells from 40 AML patients and 3 healthy donors obtained from GSE130756. We focused on the metabolic preference of AML progenitor cells and diverse immune cells, especially myeloid immune cells and T cells. Accordingly, the immune evasion mechanism of leukemia cells was proposed from the view of the allocation of energy and oxygen, providing a novel direction of treatment. Finally, we tentatively proposed potential targets for AML metabolic therapy, including ENO1, GSTP1, MT-ND4L and UQCR11. Collectively, our analysis facilitates the development of personalized therapies targeting unique immunometabolic profiles.
RNA binding proteins in MLL-rearranged leukemia
Authors: Tran Tiffany M. , Rao Dinesh S.
Published: October 2022

RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease. RBPs influence the fate of mRNAs through multiple mechanisms of action such as RNA modifications, alternative splicing, and miR-mediated regulation. This complex and, often, combinatorial regulation by RBPs critically impacts the expression of oncogenic transcripts and, thus, the activation of pathways that drive oncogenesis. Here, we focus on the major features of RBPs, their mechanisms of action, and discuss the current progress in investigating the function of important RBPs in MLL-rearranged leukemia.
Supervised segmentation of RTI appearance attributes for change detection on cultural heritage surfaces
Authors: Saha Sunita , Siatou Amalia , Mansouri Alamin , Sitnik Robert
Published: October 2022

This paper proposes a supervised segmentation method for detecting surface changes based on appearance attributes, focusing on cultural heritage metal surfaces. Reflectance Transformation Imaging (RTI) reconstruction coefficients (PTM and HSH) are explored for tracking changes over time on different data sets. Each acquisition is normalised to ensure the method’s robustness, allowing consecutive acquisitions with different RTI acquisition parameters. The proposed method requires expert labelling on groups of pixels representing individual classes. Afterward, the surface appearance is identified over time based on the estimated discriminant model. After segmentation, each detected category is assigned to a single colour to present the results with a user-friendly colourmap visualisation. The method is user-dependent; the labelling of the pixels must be accurately defined based on the research question. The results were evaluated based on human expertise in the conservation-restoration field and are considered ground truth in this work. A case study with visibly segmentable characteristics was used to prove the concept and evaluate the invariance of the proposed method. Comparison with the segmentation of the visible characteristics shows very accurate segmentation for HSH (99%) and lower for PTM (80%), which is influenced by surface rotation. The method was tested on metal surfaces undergoing accelerated corrosion or cleaning treatments. The results were promising for tracking changes based on segmentation. Equally promising is the possibility of qualitative quantifying the degree of change by counting the change of a selected class of pixels. PTM and HSH results are comparable in cases of mat surfaces; however, in high specular surfaces, HSH seems to provide more detailed information and, therefore, can better depict the surface characteristics. Limitations of the application are related to the possibility of identifying surface characteristics that do not exhibit topographic changes or significant reflectance differentiation.
Depression and post-traumatic stress disorder after perinatal loss in fathers: A systematic review
Authors: Lamon Lieselotte , De Hert Marc , Detraux Johan , Hompes Titia
Published: October 2022

Background

Research indicates that perinatal loss can cause profound psychological consequences in parents. However, a comprehensive summary of existing quantitative literature describing the association between perinatal loss and the development of depression/depressive symptoms or post-traumatic stress disorder (PTSD)/post-traumatic stress (PTS) symptoms in fathers has not been published.

Methods

A systematic literature search (from inception to December 2021), using the PubMed, EMBASE, and Web of Science databases to articles assessing depressive or PTS symptoms, was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Only studies investigating the period of intrauterine death from 20 weeks of gestation, stillbirth, or neonatal death within the first month after birth were included.

Results

A final sample of 13 articles were eligible for inclusion. Some studies showed an increased risk of depressive and PTS symptoms in fathers after perinatal loss. However, many study results did not show significant differences, symptoms generally decreased over time, and the majority of studies showed higher levels of depressive and PTS symptoms in mothers, compared with fathers.

Conclusions

Although the majority of the included studies showed elevated levels of depressive and/or PTSD symptoms after perinatal loss in fathers, no clear firm conclusion can be drawn, as the included studies were very heterogeneous. More homogeneous research measuring depressive and PTS symptoms in fathers is needed at the time of the loss, as the current literature available shows several limitations and gaps.
The Long-Run Impacts of Same-Race Teachers
Authors: Gershenson Seth , Hart Cassandra M. D. , Hyman Joshua , Lindsay Constance A. , Papageorge Nicholas W.
Published: October 2022

Leveraging the Tennessee STAR class size experiment, we show that Black students randomly assigned to at least one Black teacher in grades K–3 are 9 percentage points (13 percent) more likely to graduate from high school and 6 percentage points (19 percent) more likely to enroll in college compared to their Black schoolmates who are not. Black teachers have no significant long-run effects on White students. Postsecondary education results are driven by two-year colleges and concentrated among disadvantaged males. North Carolina administrative data yield similar findings, and analyses of mechanisms suggest role model effects may be one potential channel. (JEL H75, I21, I26, I28, J15)
Creating and sustaining collaborative multi-institutional industry site visit programs: a toolkit
Authors: Collins Tammy R.L. , Hoff Kiri , Starback Molly , Brandt Patrick D. , Holmquist Christopher E. , Layton Rebekah L.
Published: October 2022

Background: As more early career scientists enter into diverse career pathways, visiting local companies or organizations can support their exploration of these paths. As an efficient way to facilitate this, we developed a collaborative regional site visit program: the Enhancing Local Industry Transitions through Exploration (ELITE) Consortium.  Consortium members arrange half-day visits to local industry sites, thus providing companies and trainees the opportunity to meet and identify potential professional and career opportunities. Three different training institutions worked cooperatively in the development and maintenance of the program. The ELITE Consortium was developed with eight phased steps; guidelines and operating procedures were created for each of these steps and are provided along with sample materials for institutions interested in building similar programs.

Methods: Prior to fully developing the program, trainee interests were evaluated via questionnaire. During program implementation and thereafter, program directors tracked attendance and collected career outcome data from publicly available sources to identify first job positions after training. Regression analyses and chi-squared analyses were used to examine site visit matches and career outcome data.

Results: Analyses suggest a positive impact of site visits on postdoctoral and graduate trainees’ career outcomes at companies or institutions that match a similar sector (e.g., for-profit) and type (e.g., biotech, pharmaceutical, contract research organization). Despite a small sample size, evidence suggests an especially positive impact on trainees who organize site visits to companies compared with those who simply participate.

Conclusions: The ELITE Consortium was successful in helping trainees explore and identify a multitude of career paths. Trainees attained employment either directly or in related companies and institutions visited by ELITE participants. The joint, three-institution, flexible nature of the ELITE Consortium positively impacts the program’s sustainability and reach. The toolkit provided here will help other institutions to replicate and adapt the program with minimal effort.
Functional reconstruction of the thumb by heterotopic thumb-to-thumb replantation and secondary opponensplasty in bilateral amputation in the upper extremities: a case report
Authors: Lee Dong Chul , Lee Jae Yong , Koh Sung Hoon , Roh Si Young , Lee Kyung Jin , Kim Jin Soo
Published: October 2022

In traumatic amputations in the upper extremities, replantation has been commonly attempted with high success rates. However, successful replantation implies both the maintenance of length and good functional outcomes of the restored hand. Since the thumb accounts for 40% to 50% of hand function, the utmost priority is on the salvage of the thumb. In cases when replantation is not feasible, various efforts have been made to replace the thumb, including pollicization of the index finger, toe transfer, lengthening of the thumb stump, and deepening of the first web space. Alternatively, heterotopic thumb-to-thumb replantation has been suggested as a rescue plan in rare circumstances of bilateral amputation in the upper extremities. However, even if heterotopic replantation is successful, there are situations in which a severe crushing injury to the thenar muscles of the recipient’s thumb causes opposition failure of the reconstructed thumb. We report a case of functional reconstruction of the thumb in a rare case of bilateral mangling amputations in the upper extremities, by a heterotopic thumb-to-thumb replantation combined with secondary opponensplasty to compensate for the opposition failure.
How do hospital nurses experience end-of-life care provision? A creative phenomenological approach
Authors: Stuart Peter
Published: October 2022

Background:

Current evidence suggests that hospital nurses' end-of-life care is complex due to the conflicting tasks of treatment-focused care and palliation. This is a topic that needs further exploration.

Aim:

To understand hospital nurses' experiences of end-of-life care.

Method:

Interpretive phenomenology was used to explore 10 hospital nurses' experiences.

Findings:

Nurses' individual experience of death informed their attitudes to death. The dominant theme was death-as-calm, accompanied by human connection, and death-as-process. The nurses' actions indicated their end-of-life care included love, defined as a desire to create calm, grounded by the virtue of natural goodness, responsibility and dedication, with a willingness to focus on the individual and their family, making the most of whatever time they have left. To continue providing end-of-life care the nurses successfully protected their authentic self by using a ‘professional identity’ and employing ‘defence of self’. The nurses found the unpredictable nature of hospital end-of-life care difficult but used a collaborative power to manage situations.

Conclusion:

This study suggests hospital nurses successfully navigate an approach to hospital end-of-life nursing care, represented as a ‘harbour’, which facilitates transitioning from ‘stormy’ treatment to calm end-of-life care and death.
Disinfection of needleless connectors to reduce Staphylococcus aureus bacterial load
Authors: Rocha Patrícia Kuerten , Rickard Claire M. , Gales Ana Cristina , Sincero Thaís Cristine Marques , Ray-Barruel Gillian , Ullman Amanda J. , Dalcin Camila Biazus , Pedreira Mavilde L. Gonçalves
Published: October 2022

HIGHLIGHTS

Compare effectiveness of chemical disinfectants in reducing S. aureus. Five disinfectants reduced the bacterial load, especially chlorhexidine solutions. Focus on Brazilian clinical practice of needleless connector disinfection

Purpose:

This study aimed to gain further knowledge about the comparative effectiveness of chemical disinfectants in reducing the bacterial load of NCs inoculated with S. aureus.

Methods:

Disinfection of needleless connectors was undertaken in vitro against S. aureus comparing 70% isopropyl alcohol (IPA), 70% ethanol, 0.5% and 2% chlorhexidine in 70% IPA applied with gauze, and 70% IPA single-use cap (Site-Scrub®).

Results:

All disinfectants reduced the bacterial load (P<0.001), especially the chlorhexidine solutions. Mechanical friction should follow guidelines.

Conclusion:

This study found that all tested disinfectants effectively reduced the bacterial load and more clinical studies must be developed with a focus on the Brazilian clinical practice of needleless connector disinfection.
Further study on the Oriental stick insect genus Paragongylopus Chen & He, 1997, with additional descriptions and one newly recorded species from China (Phasmatodea; Bacillidae; Gratidiini)
Authors: GAO HAO-RAN , WANG ZI-ZHAO , WANG CHEN
Published: October 2022

The oriental stick insect Paragongylopus Chen & He, 1997 is a small and poorly known genus, including 9 taxa distributed in China, Thailand and Vietnam. The male and egg of most species in this genus are still unknown. In this paper, two subgenera are re-defined with three new combinations: P. (Planoparagongylopus) brevicornis (Ho, 2019) comb. nov., P. (Planoparagongylopus) obtusidentatus (Ho, 2019) comb. nov., P. (Planoparagongylopus) plaumanni (Zompro, 2000) comb. nov. The male of P. (Paragongylopus) sinensis pingbianensis and the male and egg of P. (Planoaragongylopus) obtusidentatus comb. nov. are described for the first time. Photos of P. (Paragongylopus) sinensis sinensis holotype are given with a remark of its identification with another subspecies. P. (Planoparagongylopus) abramovi is firstly recorded from Yunnan Province of China, and it documents that all species of this genus are distributed in China. A key to identifying two subgenera and a distribution map of this genus from Yunnan and the surrounding area are provided as well.
PRÁTICA DOCENTE NO ÂMBITO DA EDUCAÇÃO A DISTÂNCIA: ESTUDO COM TUTORES DE UMA INSTITUIÇÃO ESTADUAL DO RIO DE JANEIRO
Authors: Carvalho Campos Glauco , Vieira Almir Martins
Published: October 2022

O ensino na modalidade a distância tem demandado a atenção de estudiosos sobre temas como formação de professores, mediação, tutoria, metodologias e práticas de ensino. A docência, por sua vez, torna-se um desafio, visto que boa parte dos professores são bacharéis e, em sua maioria, não possuem formação pedagógica para atuar na profissão docente. Assim, o problema desta pesquisa reside na prática docente do administrador que atua como professor no EAD. Por meio de pesquisa qualitativa, apoiando-se na análise de conteúdo, objetivou-se com este trabalho analisar as práticas dos professores que atuam no curso de graduação em Administração do Consórcio CEDERJ, em busca de se identificar competências, habilidades e atitudes docentes para desenvolver uma prática pedagógica voltada para a EAD. Os resultados evidenciam que os professores exercem dupla carreira - em organizações mercadológicas e na instituição de ensino. Ademais, existem lacunas na formação docente, sendo que muitos deles promovem apenas a formação continuada, direcionada para o mercado de trabalho, tornando a prática docente mais difícil.
A UTILIZAÇÃO DO AUTOCAD WEB COMO FERRAMENTA INTERATIVA NO PROCESSO DE ENSINO APRENDIZAGEM DA DISCIPLINA DE DESENHO TÉCNICO NO ENSINO SUPERIOR
Authors: Galli do Rosário Terezinha , Schimiguel Juliano
Published: October 2022

Este artigo tem como objetivo, apresentar e discutir sobre os desafios e oportunidades que o uso das tecnologias educacionais oferece para as aulas práticas e os principais resultados para que qualquer estratégia de ensino remoto tenha possibilidade de êxito. Após publicação sobre a situação pandêmica no país em 2020, o Ministério da Saúde e o Ministério da Educação emite em seus sites protocolos sanitários que exigem no momento o fechamento de escolas e instituições de ensino superior. Esta nova realidade mostrou a necessidade de soluções tecnológicas disponíveis e diversas adaptações pedagógicas. Foi realizado um estudo de caso com estudantes do curso de engenharia em um curso superior. Os resultados evidenciaram as fragilidades enfrentadas, e a busca por soluções que incorporem o uso inovador das tecnologias digitais associadas ao trabalho remoto.
AULAS VIRTUAIS PARA OS CURSOS DE GRADUAÇÃO PRESENCIAL DEVIDO À PANDEMIA DA COVID-19 AO OLHAR DOS DOCENTES E DISCENTES DE UMA INSTITUIÇÃO PRIVADA
Authors: Silva Rodrigo Rogerio Cerqueira
Published: October 2022

O início do ano de 2020 é marcado pela interrupção das atividades de educação em todo o país diante do cenário epidêmico provocado pela Covid-19. As Instituições de Ensino Superior tiveram rapidamente, que substituir as aulas presenciais por aulas que utilizassem meios e tecnologias de informação e de comunicação, como alternativas que diminuíssem os impactos causados pela paralisação. Assim a presente pesquisa investigou a adoção do ensino remoto quanto à satisfação e desempenho dos docentes e discentes, de diferentes áreas da graduação, através de uma análise quantitativa descritiva. Os resultados indicam que a maioria dos jovens docentes e discentes demonstram facilidades e enxergam oportunidades oferecidas pelo processo de ensino remoto, devido o uso de tecnologias fazer parte do seu cotidiano. O efeito pós- pandemia leva a uma nova visão para as atividades presenciais, reestruturado as salas de aulas através de novas tecnologias para abordagem de novas metodologias ativas de ensino.
EDUCAÇÃO BILÍNGUE PARA SURDOS: DISTINTAS COMPREENSÕES E IMPLEMENTAÇÕES
Authors: Nascimento Lilian Cristine Ribeiro , Moriconi Lucimara Valdambrini
Published: October 2022

Este artigo tem por objetivo apresentar as distintas interpretações sobre educação bilíngue para surdos no estado de São Paulo, que resultam em diferentes propostas de educação para pessoas surdas. Para isso foi realizada uma pesquisa de cunho qualitativo, partindo da análise das leis federais que regem a educação de surdos, comparando-as com a política estadual e também com as políticas locais de 4 municípios do estado de São Paulo. Além disso, foram realizadas pesquisas de campo nas unidades escolares possibilitando constatar se as proposições legais eram, de fato, efetivadas nas práticas escolares. Os dados coletados nas unidades escolares são referentes ao ano de 2018. Como resultado, verificou-se que as políticas implantadas pelo estado e pelos municípios analisados, em sua maioria, não contemplam em sua totalidade a legislação federal, nem atendem às demandas da comunidade surda.
IMAGEM MENTAL NA PESSOA CEGA: REPRODUÇÃO, TRANSFORMAÇÃO E ANTECIPAÇÃO DO OBJETO
Authors: MachadoTomazi Gustavo MachadoTomazi
Published: October 2022

Apresenta resultado de estudo de doutoramento que teve como objetivo identificar as capacidades imaginativas e criativas e os processos cognitivos relacionados às imagens mentais de pessoas cegas. Para tanto, embasou-se no Tratado de Psicologia Experimental, de Olerón et al. (1969) e no Método Clínico, de Piaget (2015), realizando as adaptações necessárias para poder ser aplicado ao público-alvo em questão, tendo o cuidado de privilegiar a acessibilidade e materiais simples do cotidiano na confecção do instrumental das provas. Tal método contempla os estágios de abstração para a busca de soluções, assim como para a obtenção dos resultados. As análises dos dados obtidos visaram conhecer a capacidade das pessoas cegas elaborarem mentalmente cópias gráficas, transformações de objetos antecipações de seus deslocamentos. E os resultados obtidos indicaram a necessidade de aprofundar o conhecimento relativo à construção da imagem mental em sujeitos privados do sentido da visão desde a nascença, para possíveis desdobramentos de construção semelhantes em pessoas videntes
BNCC, EDUCAÇÃO DOMICILIAR E REFORMA DO ENSINO MÉDIO: PARA ONDE CAMINHA A EDUCAÇÃO INCLUSIVA NO BRASIL?
Authors: De Oliveira Evangelista Lanuti José Eduardo , Sampaio Dias Baptista Maria Isabel
Published: October 2022

O cenário educacional brasileiro vem sofrendo muitas transformações, difundidas intencionalmente por meio de um discurso mercadológico que visa transmitir a ideia de que tais mudanças caminham na direção de reformas progressistas. Como professores e pesquisadores, temos percebido que, na realidade, essas propostas são retrógradas e vêm provocando verdadeiro desmonte das políticas públicas educacionais e, em decorrência, das conquistas alcançadas ao longo das últimas duas décadas no país. O objetivo deste texto é analisar o impacto negativo que três dessas propostas exercem sobre a inclusão escolar e revelar a ideologia nelas contidas. Como resultados, destacamos a exclusão causada pela tentativa de homogeneização da aprendizagem almejada pela BNCC, a violação do direito inalienável ao acesso à educação escolar resultante do ensino domiciliar (homeschooling), e a falsa autonomia dos estudantes e esvaziamento do Ensino Médio, diante de sua atual reforma.
Kultpraxis und Distinktion. Bildnisse von Kultpersonal der römischen Kaiserzeit aus Rom und Italien
Authors: Schantor Annemarie
Published: October 2022

Annemarie Schantor untersucht erstmals alle kaiserzeitliche Porträts aus Rom und Italien, die Inhaber:innen von Kultämtern zeigen. Aber wie genau wurden die Ämter und ihre Attribute genutzt, um die dargestellte Person zu charakterisieren? Um diese Frage zu beantworten, wurde das Repertoire der Kultkennzeichen mit dem in den schriftlichen Zeugnissen und in den generischen Darstellungen überlieferten verglichen. Dabei wurde deutlich, dass nicht alle Attribute eines Kultes in den Selbstdarstellungen genutzt wurden. Stattdessen wurden einige wenige ausgewählt – stets unter dem Gesichtspunkt ihrer positiven Wirkung. Wichtige Faktoren waren Tradition und Luxus. Wurden bislang die Bildnisse als objektiv-dokumentarische Zeugnisse des jeweiligen Kultes gedeutet, so kann die Autorin aufzeigen, dass die Kultzeichen häufig ungewöhnliche, von den Konventionen des römischen Porträts abweichende Attribute waren. Die Religion war dabei dasjenige Feld, das die meisten Abweichungen von den Konventionen des römischen Porträts erlaubte. Schantor gibt mit ihrer Studie nicht nur neue Impulse für die Erforschung der antiken Religion, sondern zeigt zudem, dass in einem Bildnis nicht nur das Kultamt, sondern mehrere Rollen der Dargestellten und damit ein vielschichtiges Bild der porträtierten Person präsentiert werden konnten.
Light funneling by spin-orbit-coupled chiral particles on an arbitrary order exceptional surface
Authors: Zhang Chengzhi , Cheng Yuqiong , Wang Shubo
Published: October 2022

Optical systems at non-Hermitian exceptional points (EPs) have intriguing properties that promise novel applications in light manipulations. Here, we realize an arbitrary order exceptional surface (ES), i.e., a surface of arbitrary order EPs, in chiral particles that couple with each other via the photonic spin-orbit interaction mediated by a dielectric waveguide. The chirality of the particles enables selective excitation of the chiral dipole modes by linearly polarized light. The unidirectional coupling of the chiral dipole modes gives rise to the ES in the parameter space defined by the material loss and coupling distance of the particles. We apply the system to realize a light funnel that can convert free-space plane waves to guided waves and funnel the incident light energy into a ring resonator. The results can find applications in designing optical switches, on-chip conversion of guided waves, and harvest of light energy.
Single-shot lensfree on-chip quantitative phase microscopy with partially coherent LED illumination
Authors: Chen Yang , Wu Xuejuan , Lu Linpeng , Wei Jiahao , Wu Yumin , Chen Qian , Zuo Chao
Published: October 2022

We propose a single-shot lens-free phase retrieval (SSLFPR) method in a lens-free on-chip microscopy (LFOCM) system based on a partially coherent light emitting diode (LED) illumination. The finite bandwidth (∼23.95 nm) of LED illumination is divided into a series of quasi-monochromatic components according to the LED spectrum measured by a spectrometer. When the “virtual wavelength scanning” phase retrieval method is combined with the dynamic phase support constraint, the resolution loss caused by the spatiotemporal partial coherence of the light source can be effectively compensated. At the same time, the nonlinearity characteristics of the support constraint help to further improve the imaging resolution, accelerate the convergence of the iteration process, and greatly eliminate the artifacts. Based on the proposed SSLFPR method, we demonstrate that the phase information of samples (including phase resolution target and polystyrene microspheres) illuminated by a LED can be accurately retrieved based on one single diffraction pattern. The SSLFPR method has a half-width resolution of 977 nm across a large field-of-view (FOV) of 19.53 mm2, which is 1.41 × the resolution of the conventional approach. We also imaged living Henrietta Lacks (HeLa) cells cultured in vitro, further demonstrating the real-time single-shot quantitative phase imaging (QPI) capability of SSLFPR for dynamic samples. Given its simple hardware, high throughput, and single-frame high-resolution QPI capability, SSLFPR is expected to be adopted in a wide range of biological and medical applications.
Sub-wavelength passive single-shot computational super-oscillatory imaging
Authors: Yang Haitang , Lin Esther Y. H. , Kutulakos Kiriakos N. , Eleftheriades George V.
Published: October 2022

Super-oscillatory (SO) imaging presents a passive solution to the sub-diffraction imaging challenge. The point spread functions (PSFs) of SO systems are band-limited and locally oscillate faster than their highest Fourier frequency. Because of this property, SO imaging systems are not bound by the Nyquist limit, allowing them to acquire details finer than the diffraction limit. In this work, we present a comprehensive theoretical analysis of passive incoherent SO imaging, leading to two key results. First, we show that the SO property of an imaging system is preserved when the system is combined with a general system of lenses. This opens the door for integrating SO imaging into existing microscopes and telescopes. Second, we show that incoherent SO imaging cannot resolve feature sizes below

λ

/

2

because of the inability to achieve incoherence at finer scales. This establishes the operational limits of the approach. We demonstrate our theory experimentally with a compound SO system that achieves sub-wavelength resolutions using high-NA lenses and Fourier spectrum modulation.
Risk of cervical precancer among HPV–negative women in the Netherlands and its association with previous HPV and cytology results: A follow-up analysis of a randomized screening study
Authors: Inturrisi Federica , Rozendaal Lawrence , Veldhuijzen Nienke J. , Heideman Daniëlle A. M. , Meijer Chris J. L. M. , Berkhof Johannes
Published: October 2022

Background

Human papillomavirus (HPV)-based screening programs still use one-size-fits-all protocols but efficiency and efficacy of programs may be improved by stratifying women based on previous screening results.

Methods and findings

We studied the association between cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) and previous screening results in the Population-Based Screening Study Amsterdam (POBASCAM) trial, performed in the Netherlands in the setting of regular screening, where women aged from 29 to 61 years old were invited to cytology and HPV co-testing at enrolment in year 1999/2002 and at the next round in 2003/2007. We selected 18,448 women (9,293 from the intervention group and 9,155 from the control group) who tested HPV–negative in 2003/2007 and did not have cervical intraepithelial neoplasia grade 2 or worse (CIN2+) or hysterectomy after enrolment. Follow-up was collected until 14 years after the 2003/2007 screen, covering 4 rounds of screening. Risk of CIN3+ and CIN2+ among women with an HPV–negative test, irrespective of previous round results and stratified according to previous round HPV and cytology results, were calculated by the Kaplan–Meier method.

During 14 years of follow-up, 62 CIN3+ cases (24 in the intervention group and 38 in the control group) were detected. HPV–negative women had a 14-year CIN3+ risk of 0.48% (95% confidence interval 0.37 to 0.62) and CIN2+ risk of 1.17% (0.99 to 1.38). The CIN3+ risk among HPV–negative women was increased in women with a previous positive HPV test (2.36%, 1.20 to 4.63; p < 0.001) or co-test (1.68%, 0.87 to 3.20; p < 0.001) and, equivalently, decreased in women with a previous negative HPV test (0.43%, 0.33 to 0.57) or a negative co-test (0.43%, 0.33 to 0.57). The CIN3+ risk was not influenced by the previous cytology result. The CIN3+ risk among HPV–negative women was increased after both a previous HPV16–positive test (3.90%, 1.47 to 10.12; p < 0.001) and a previous HPV16–negative/HPVother–positive test (1.91%, 0.76 to 4.74; p = 0.002). For endpoint CIN2+ (147 cases), findings were similar except that the CIN2+ risk was increased after previous abnormal cytology (4.06%, 2.30 to 7.12; p < 0.001). The presented risk estimates were calculated by tracking histological results through the Dutch nationwide pathology archive (PALGA) and were not adjusted for non-compliance with the colposcopy referral advice.

Conclusions

HPV–negative women had an increased long-term risk of CIN3+ when the HPV test in the previous screening round was positive. This supports the implementation of risk-based intervals that depend on HPV results in the current and previous screening round.

Trial registration

POBASCAM trial, trial registration number ISRCTN20781131.