bluuebunny/crossref_metadata_2025 huggingface dataset:
EPIDEMIOLOGICAL ANALYSIS OF BREAST CANCER AND FEATURES OF MEDICAL CARE FOR WOMEN IN THE ARCTIC REGION OF NORTH-WEST RUSSIA (ARKHANGELSK REGION)
Authors: A.L. Sannikov , R.V. Kubasov , P.S. Koptyaeva , K.A. Steshenko , A.A. Dahina
Published: February 2023

Relevance: epidemiological studies of breast cancer are due to the fact that this nosological form is one of the leading among all other malignant neoplasms detected in the female population not only of the Arkhangelsk region, but also of the Russian Federation. Over the past decade, there has been an increase in the incidence of this pathology. The article analyzes the statistical indicators of morbidity and mortality from breast cancer from 2010 to 2020; the results obtained in the Arkhangelsk region are compared with those in the Russian Federation as a whole. The aim of the study is to identify the features of the prevalence of breast cancer and its consequences among the female population living in the Arkhangelsk region, as well as problems in the system of prevention, early diagnosis, medical care and rehabilitation of patients. Materials and methods: statistical data on the situation associated with cancer incidence in one of the largest and most densely populated Arctic territories (Arkhangelsk region) were used. Research results: over the past decade, from 2010 to 2019, the incidence of breast cancer in women living in the Arkhangelsk region has steadily increased; only in 2020 there was a significant decrease in this indicator. At the same time, breast cancer mortality was gradually decreasing. Over the past 5 years, there has been a clear trend of success in early diagnosis of breast cancer, which significantly increases the chances of survival in the fight against this disease, improves the quality of life of patients. Such positive results are largely due to the implementation of the federal program "Fight against oncological diseases" in each region.
DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF A COCKTAIL TEST SYSTEM FOR RATIONAL PHARMACOTHERAPY
Authors: A.S. Svetozarov , R.A. Abramovich , O.G. Potanina , A.N. Vorobyev
Published: February 2023

Cocktail test systems are being used for determination of individual activity of cytochrome P450 isoenzymes in a patient. The usage of test systems allows taking into account the phenotypic features of drug metabolism to prescribe the most effective drug therapy.
Aim. Development of a test system in the form of a solid gelatin capsule containing microtablets of caffeine, efavirenz, flurbiprofen, metoprolol tartrate and evaluation of their technological properties. Development of a method for the determination of marker components of a "cocktail" formulation using the Proton NMR spectroscopy method.
Materials and methods. Microtabletes containing caffeine, efavirenz, flurbiprofen (Molekula Limited, UK) and metoprolol tartrate (KONO Chem Co., LTD, China) were manufactured on a tablet press of the XSpress type (BOSCH, Germany), in one of the sockets of which a 12-punch press tool with a diameter of 2 mm matrix holes was inserted. The resulting microtablets passed pharmaceutical and technological tests for dosage forms in accordance with the Pharmacopoeia of the Russian Federation XIV edition. Finnipipette F1 mechanical pipettes were used to sample the solvent and analytic solution, and a Vortex 2 shaker, an ultrasonic water bath, a Minispin Plus centrifuge, benzoic acid, and DMSO-d6 were used for sample preparation.
Results and discussion. A common solvent has been selected for all active substances of the test system. Conditions for the introduction of probe preparations into the filler substance of the sorbent have been selected. Tableting parameters have been worked out.
Conclusion. As a result of the conducted research, the composition and production technology of a cocktail test system for rational pharmacotherapy have been developed. A technological scheme for obtaining microtablets of probe preparations has been developed. For a mixture of active substances, the conditions for quantitative analysis were selected using the Proton NMR spectroscopy method.
DETERMINATION OF THE RELATIVE ANTIOXIDANT ACTIVITY AND TANNIN CONTENT IN MEDICINAL HERBS GROWING IN THE REPUBLIC OF MORDOVIA
Authors: I.V. Abrashina , E.A. Alyamkina
Published: February 2023

Relevance. Medicinal plants can serve as a rich source of natural exogenous antioxidants and antimicrobial agents, such as phenolic acids, flavonoids and tannins. Therefore, the study of extracts of plant raw materials as natural sources of antioxidants is a modern relevant task.
Purpose. To study the content of tannins and relative antioxidant activity in 8 types of medicinal plants growing in the Republic of Mordovia.
Materials and methods. The raw materials of the aboveground parts of eight medicinal plants growing in the Republic of Mordovia, dried by the air-shadow method, served as the material for the study. The content of tannins was determined by the permanganatometric method. Relative antioxidant activity was determined by phosphorous-molybdenum colorimetric method.
Results. The article presents the results of studying the content of tannins (polyphenolic compounds) in 8 types of medicinal plants growing in the Republic of Mordovia, and gives an assessment of their antioxidant activity. It was revealed that the largest amount of tannins is contained in fireweed (Chamerion angustifolium). The highest relative antioxidant activity was noted in an aqueous extract obtained from St. John's wort (Нуреricum реrfоrаtum). Also, extracts of chamomile pharmacy, fireweed, field horsetail showed high relative antioxidant activity. It is established that there is a correlation between the content of tannins and the relative antioxidant activity of the aqueous extracts of the studied medicinal plants. The ratio of antioxidant activity to the content of tannins provides additional data on the contribution of tannins to the antioxidant activity of extracts of the studied medicinal plants. The lower this ratio, the more significant contribution condensed tannins make to the antioxidant activity of the studied extract. If this ratio increases, then the antioxidant activity is determined by other chemicals, including polyphenolic nature, while the contribution of tannins is inversely proportional to the increase in this ratio. By the ratio of antioxidant activity to the content of tannins, we can also judge the qualitative composition of tannins, that is, the ratio of hydrolyzable tannins to condensed ones.
Conclusion. The results of this study provide information on the content of phenolic compounds in some types of wild plant raw materials of the Republic of Mordovia and the antioxidant activity of extracts based on them, which will contribute to the use of the studied plants as a potential source of natural antioxidants and tannins.
Keywords: antioxidants, relative antioxidant activity, medicinal herbs, phosphorous-molybdenum colorimetric method, tannins.
COMPARATIVE ANALYSIS OF PAIN SYNDROME ASSESSMENT METHODS IN PATIENTS WITH SPINAL PATHOLOGY
Authors: E.A. Korotaevsky , A.G. Kalinin , N.A. Martynova , R.V. Kubasov , O.E. Karyakina
Published: February 2023

Relevance: currently, more than half of the population suffers from diseases of the musculoskeletal system. Among them, a significant part are people of working age from 30 to 50 years. As a rule, these diseases are caused by pathology of the spine, joints, ligaments and muscles. The most common symptom of them is pain in the lower back and neck. Such a problem carries a huge social, psychological and economic burden. The purpose of the study is assessment of pain syndrome in the spine using various scales to objectify its level and severity of movement disorders. Materials and methods: patients with pain syndrome of various parts of the spine were examined. A visual-analog scale was used to assess the intensity of pain, and specialized questionnaires were used to calculate the degree of locomotor limitations. Results of the study: according to the severity of the pain syndrome (depending on the localization of the affected spine) among the examined patients, about half of the cases had soft strength, in a third of cases – moderate, from 3 to 18% of individuals experienced severe pain. The use of the "Visual-analog scale" technique for differential diagnosis and determination of the localization of spinal lesions has shown its poor effectiveness. The use of specialized questionnaires "Assessment of the degree of move limitations" turned out to be more relevant for determining the topography of the pain syndrome. Correlation analysis revealed statistically significant positive strong and moderate correlations between the scores obtained from the methods of self-assessment severity of pain syndrome and the intensity of move limitations. The conclusion: the data obtained suggest the differentiated using of visual-analog scale methodic and indices of move limitations for a refined assessment of pain syndrome in patients, decision-making and prognosis in a particular patient.
EFFECT OF EMOTIONS INDUCED BY SOUNDS ON HEART RATE VARIABILITY
Authors: D.A. Dimitriev , O.S. Indeykina , Kh.M. Bataev
Published: February 2023

The level of knowledge of increased emotional response may differ significantly from individual interpersonal dynamics and the etiology of psychopathology. Heart rate variability (HRV) analysis is an objective measure for assessing a regulated emotional response. At present, it remains unclear to what extent the valency of emotions affects the central and peripheral mechanisms of heart rhythm regulation; this is especially true of the emotions induced by listening to sound. a set of precise indicators of perception, in the experiments of which we observed comparable dynamics of HRV indicators, which are significant vegetative manifestations of an emotional response to a stimulus. It was found that stimuli with a negative emotional response cause a significant decrease in total heart rate variability (SDNN) and the severity of fast heart rates (RMSSD) against the background of heart rate. Negative emotions decrease, and positive emotions increase in the severity of respiratory arrhythmias (LF and HF), which disrupts the stabilization of the function of the nervous part of the autonomic nervous system (ANS). In addition, listening to a sound with a negative emotional connotation leads to a significant modulation of the internal rhythm, the dynamics of the heart, which is manifested by changes in the shapes and sizes of clouds on the Poincaré graph. The scope of the results of our study may lead to the emergence that the occurrence of background phenomena, as a partial natural landscape, may manifest itself in a significant degree of activity of the ANS and, thus, relates to the risk of spreading a widespread disease related to vegetative volume dysfunction.
EXPERIMENTAL AND THEORETICAL STUDY OF DOMESTIC STANDARD SAMPLES ON THE EXAMPLE OF FAT-SOLUBLE VITAMINS
Authors: E.B. Sysuev , V.D. Noskova , E.F. Stepanova , E.A. Salimgireeva
Published: February 2023

Nowadays, a number of pharmaceutical manufacturing technologies are closely related to the issues of research and the use of reference materials (RM). Fat-soluble vitamins are very significant in this group. This article discusses the possibilities of obtaining fat-soluble vitamins using low-waste resource-saving domestic technologies and using original purification methods; which allows us to assume the creation of domestic RM and relevant regulatory documents (RD) for their subsequent approval. The scientific novelty of the research lies in the development of an original domestic technology for obtaining the material and RM-fat-soluble vitamins. For the first time, low-waste technologies and original cleaning methods will be used for this purpose. For the first time, emphasis will be placed on the interaction of the obtained samples with related industries of production and science. Technological and regulatory documents confirming the effectiveness of the work will be created for the first time. Thus, for the first time will be created and approved from domestic production.
DEVICE FOR CLOSED REPOSITION, FIXATION OF BONE FRAGMENTS AND SUBSEQUENT ORIF PATIENTS WITH DISTAL HUMERUS FRACTURES
Authors: E.S. Kozlov , Yu.P. Soldatov
Published: February 2023

Background. Intra-articular fractures of the distal humerus are complex injuries that can subsequently significantly limit the function of the elbow joint. Transosseous osteosynthesis has a number of undeniable advantages: low trauma, accurate reposition of bone fragments using closed methods, stable fixation of bones, early movements in the injured joint both with and without hinges. However, this method of surgical treatment is not without a number of complications.
Objective. Develop and test a device for closed reposition, fixation of bone fragments in patients with fractures of the distal humerus and subsequent ORIF.
A device has been develop for closed reposition, temporary fixation of bone fragments in patients with fractures of the humerus condyle and subsequent ORIF. In 24 patients with intra-articular fractures of the distal humerus (according to the AO classification: 13 - C2 - C3), internal fixation was performed. In patients of the first group (comparison group, 14 cases), one-stage open osteosynthesis with submersible fixators was performed within 4–14 days after injury. In patients of the second group (main group, 10 cases), a two-stage treatment of fractures of the condyle of the humerus was carried out using the developed device.
Results. All patients of the main group achieved good results of treatment: no complications were detected; the timing of fracture consolidation did not differ from the average.
USING MATHEMATICAL MODELING TO OBJECTIFY THE LEVEL OF PAIN AND SEVERITY OF MOTOR DISORDERS IN PATIENTS WITH DORSOPATHY
Authors: E.A. Korotaevsky , A.G. Kalinin , N.A. Martynova , O.E. Karyakina , R.V. Kubasov
Published: February 2023

Relevance: diseases of the musculoskeletal system affect about half of the population. The pain caused by this pathology leads to a person's disability, which is a serious problem for everyone. There are many possibilities for diagnosing spinal diseases and assessing the condition of such patients. One of their promising and fairly objective diagnostic methods is the use of mathematical models that allow predicting a particular indicator based on already known. The purpose of the study is design of mathematical models to objectify the level of pain syndrome and the severity of motor disorders in patients with pain syndrome in various parts of the spine. Materials and methods: patients with pain syndrome of various parts of the spine were examined. A visual-analog scale was used to assess the intensity of pain, and specialized questionnaires were used to calculate the degree of motor limitations. The obtained results were processed by the method of multiple regression analysis with the construction of models-equations of the dependence of indicators on each other. Results of the study: in groups of patients with prevalence of pain in the neck and thoracic spine, statistically significant, proven models-equations were obtained that determined the dependence of the final scores of the methods of visual analog pain scale and the index of limited movements due to pain on the magnitude of the deviation of the angles of various reference points relative to the vertical axis of the body. The power level of the influence of the force of the deviation of the angles on thein groups of patients with prevalence of pain in the neck. It is concluded that it is expedient to use these models in practical healthcare for a more objective and error-free diagnosis of spinal diseases.
ANTITUMOR AND ANTI-INFLAMMATORY PROPERTIES OF TANNINS OF PLANT ORIGIN AND PERSPECTIVES OF THEIR USE IN PHARMACY
Authors: E.D. Kubasova , I.A. Krylov , G.V. Korelskaya , K.A. Pantyuhova , R.V. Kubasov
Published: February 2023

Tannins obtained from plants belong to pharmacopoeia preparations. Among their numerous properties used in pharmacology, antitumor and anti-inflammatory effects are of particular importance. There are many hypotheses regarding the mechanisms of the anticarcinogenic effect of tannins obtained from plant raw materials. All of them have not only theoretical, fundamental, but also experimentally proven confirmation. In this regard, carcinogenesis is a whole complex of interrelated biochemical processes. Accordingly, for its treatment, it is necessary to take into account and use a variety of therapeutic effects. In general, tannins act as anti-initiatory and anti-stimulating agents. In most studies, the anticarcinogenic and antimutagenic potential of tannins may be related to their antioxidant properties, which are important for protecting cells from oxidative damage, including lipid peroxidation. The antitumor effects of tannins are mainly mediated by the negative regulation of transcription factors, growth factors, receptor kinases and many oncogenic molecules. When directly treating tissues containing tumor cells with tannin compounds, their viability is suppressed by stopping the cell cycle and inducing internal pathways of apoptosis. In addition, treatment with tannic acid suppresses various functional processes that ensure the viability of malignant cells, including invasion, migration and stemming. As for the antimicrobial activity of tannins, they have a wide spectrum of action due to the suppression of the growth of bacteria, viruses and many fungi. Antimicrobial mechanisms are also quite extensive. They can be caused by the destruction of the integrity of the cell wall of the microbe, antioxidant properties, blocking of the receptor apparatus, life-supporting enzymes of viruses and fungi.
INVESTIGATION OF THE COMPONENT COMPOSITION OF CARBON DIOXIDE EXTRACT OF SCHISANDRA CHINENSIS SEEDS
Authors: Yu.A. Morozov
Published: February 2023

Schisandra chinensis (Turcz.) Baill. of the Schisandraceae family is a bright representative of medicinal plants from the group of classical plant adaptogens. Schisandra chinensis seeds are an official medicinal plant raw material included in the State Pharmacopoeia of the Russian Federation of the 14th edition, on the basis of which it is possible to create new medicines in modern dosage forms capable of having an adaptogenic and general ionizing effect on the human body. However, in the domestic pharmaceutical market, Schisandra preparations are presented only in the form of a traditional tincture, the use of which is limited due to objective reasons. According to many authors, the predominant form for Schisandra seeds is its oil form. We have proposed the main parameters for obtaining carbon dioxide extract under supercritical conditions from Schisandra chinensis seeds. Therefore, the main purpose of this work was to study the component composition of supercritical carbon dioxide extract of Schisandra chinensis seeds. Using the gas chromatography/mass spectrometry method, 41 compounds belonging to various classes were identified in the studied Schisandra extract. It was experimentally established that the content of monoterpenes was 17,38 %, sesquiterpenes 22,45 %, terpenoids (alcohols, esters, ketones) – 14,99 %) and aromatic substances – 1,66 %. The obtained results also indicate the dominant presence of lignans (43,52 %) in the studied extract. Among which the largest number corresponds to schizandrin (15,68 %) and γ-schizandrin (11,44 %). The component composition of the carbon dioxide extract of Schisandra chinensis seeds, both in terms of the qualitative and quantitative content of biologically active substances, allows it to be further considered as an active composition in the development of new dosage forms.
ALGORITHM FOR PREDICTION OF ACUTE KIDNEY INJURY DURING MYOCARDIAL INFARCTION IN MALES UNDER 60 YEARS OLD
Authors: B.B. Tassybayev
Published: February 2023

Relevance. Acute kidney injury (AKI) in myocardial infarction worsens the prognosis and increases the duration of treatment of patients.
Aim. To evaluate the significance of the AKI development predictors during MI in males under 60 years old. To create a model for predicting the risk of developing this complication in the form of a diagnostic algorithm to improve prevention and outcomes.
Material and methods. The study included men 32-59 years old (y.o.) with type I MI. Patients were divided into two age-comparable groups: I - study group, with AKI - 25 patients; II - control, without it - 166 patients. Pearson's Chi-square method was used to assess the absolute (AR) and relative (RR) risks of developing AKI under the influence of various factors. Mathematical modeling of the risk of developing this complication was performed using the classification tree method.
Results. Among the features of predictors of AKI in myocardial infarction in the examined patients in comparison with the established risk factors for its development, the following were distinguished: stress (AR: 15.9%; p=0.01), winter season (AR: 21.8%; RR: 3.1; p=0.003), hypertriglyceridemia (≥1.8 mmol/l) (AR: 23.0%; p=0.007) and peptic ulcer (AR: 25.8; RR: 2.5; p=002). For the decision tree, the most significant of them were the winter period of the year and the value of the patient's systolic (sys) blood pressure (BP) in the first hours of MI. With the help of a decision tree, four risk classes are identified. The highest risk level (30.2%; group size = 53) was in patients with MI in the winter period and BPsyst≥130 mmHg. The lowest risk level (0.0%, group volume = 45) for the development of AKI was observed for MI in spring, summer and autumn periods and BPsyst˂135.0 mm Hg. With BPsyst≥135 mm Hg. during these periods, the risk of developing AKI increases to 11.6% (69 patients). In winter, with a decrease in BP˂130 mm Hg. the risk of developing AKI is reduced to 4.2% (24 people). The sensitivity of the model was 94.1%; specificity - 70.9%; efficiency - 82.5%.
Conclusions. Additions to the known predictors of the development of AKI in MI in males under 60 y.o. were: the winter period, stress, hypertriglyceridemia in the first hours of MI (≥1.8 mmol/l) and a history of peptic ulcer disease. Based on a combination of BP and winter period indicators, a model for assessing the risk of development this complication was built. It allows identifying a risk group for development AKI among patients with MI for follow-up and timely preventive and therapeutic measures.
HIGH METABOLIC RISKS AMONG ADOLESCENTS 12-17 YEARS OLD WITH OVERWEIGHT.
Authors: M.V. Pisareva , G.S. Maskova , D.D. Mikhailovа , E.Yu. Sokolova
Published: February 2023

Overweight children are considered as a risk group for the development of obesity and the formation of metabolic and cardiovascular risks. However, studies on the state of the metabolic status of overweight children depending on the amount of fat mass in the body are not enough. The aim of this study was to assess the metabolic status of overweight children aged 12–17 years in order to identify children in high metabolic risk groups. We examined 107 overweight adolescents aged 12–17 years who underwent an extended assessment of anthropometry (body mass index (BMI), waist circumference (WC), hip circumference (OB), the sum of the thickness of 4 skin-fat folds, bioimpedance analysis of body composition), the level of blood pressure (BP) and the determination in venous blood of glucose, insulin, cholesterol (TC), triglycerides (TG), high-density lipoproteins (HDL-C) and low density (LDL-CL), leptin, interleukin-6 and C- reactive protein. The study has showed that children with increased body fat mass (more than 85 percentile) and elevated WC (75 ≤ WC < 90) have the highest metabolic risks, who have an increase in systolic blood pressure, changes in carbohydrate and fat metabolism at high leptin values, 16,43[17,0 – 32,7] (ng/ml). We have established the gender characteristics of metabolic risks: in boys, the atherogenic risk of vascular damage increases, and in girls, the risk of insulin resistance. The data obtained allow us to recommend a differentiated allocation of groups of increased metabolic risk depending on age, gender, amount of fat mass in the body composition and waist circumference for individual observation.
THE DEVELOPMENT OF THE DENTAL INDUSTRY IN THE TRANSFORMATIONAL REALITIES OF THE GEOPOLITICAL SITUATION
Authors: N.N. Shurova , T.P. Goryacheva , O.A. Aleshina , I.S. Kotikov
Published: February 2023

Dentistry is a multicomponent intersectoral link of medicine that connects various suppliers into one single point. Dentistry was not directly affected by anti-Russian sanctions, but indirectly geopolitical changes affected the entire dental services market. The greatest impact on the dental industry in Russia was the creation of restrictions or a ban on the supply of materials and high-tech equipment. The country's healthcare needs against the background of transformational realities have actualized the issue of analyzing the market situation and strategic planning of organizational activities in the field of medicine in general and in the dental industry in particular. A dynamic analysis of the situation on the market of dental services in the Nizhny Novgorod region under the conditions of the sanctions policy of the West by positions: pricing policy of clinics in different periods, features of providing clinical dental admission in all specialties, availability of dental materials. Against the background of the creation of anti-Russian sanctions, there was an increase in the level of consolidation of dental business participants, flexibility in the market policy of clinic managers, as well as the formation of a motivational basis for the participation of medical organizations of various forms of ownership in the scientific agenda of the region in the context of the development of new materials and equipment. It was noted that special attention should now be paid to solving existing economic problems, building a strategy of interaction with friendly countries, searching for optimal points of economic interaction while taking into account possible risks. Participants in the dental business in constantly changing market conditions need to prioritize the development of resource and personnel, information and innovation and technology sectors of the intra-industry market.
CARDIOVASCULAR COMPLICATIONS IN NON-SMALL CELL LUNG CANCER PATIENTS: CURRENT STATUS OF THE PROBLEM
Authors: E.Yu. Felanyuk , N.G. Lozhkina , A.A. Filippov
Published: February 2023

Patients with lung cancer constitute a special group in the modern world. Cardiovascular diseases and complications associated with antitumor treatment affect prognosis of patients with non-small cell lung cancer. This determines the importance of risk stratification, selection of optimal personalized therapy, study of long-term prognosis, and search for new prognostic markers. We conducted a systematic review to summarize important aspects of the treatment of patients with non-small cell lung cancer. The authors discuss adverse events associated with the use of polychemotherapy, immune therapy, as well as biochemical, metabolomic and genetic markers of cardiovascular damage.
IDENTIFICATION OF IMPURITIES IN THE PHARMACEUTICAL SUBSTANCE LS-1269 BY HPLC-MSMS
Authors: D.A. Kozin , Z.S. Shprakh , A.P. Budko , R.B. Pugacheva , L.V. Ektova , V.A. Eremina , D.V. Gusev , V.Yu. Reshetnyak , O.V. Nesterova
Published: February 2023

The N.N. Blokhin Oncology Research Center synthesized indolo[2,3-a]carbazole N-glycoside, which received the laboratory cipher LСS-1269, which showed a pronounced antitumor effect during research.. During the study of LСS-1269 by HPLC, the presence of two impurities was revealed, called LСS-1269-X and LСS-1269-Y (impurities X and Y). The electronic absorption spectrum (EAS) of the impurity peak X was similar to the EAS of the indolo[2,3-a]carbazole N-glycoside obtained and described earlier under the laboratory cipher LCS-1208, and the EAS of the impurity was the spectrum of LCS–1269, which indicates that the impurities belong to indolo[2,3-a]carbazoles. In this regard, it is suggested about the structure of these impurities: impurity X is a xyloside of aglycone similar in structure to aglycone LCS-1208, which can be formed as a by-product at one of the last stages of the synthesis of LCS-1269, and impurity Y has the structure of triacetyl ester LCS-1269, which is a precursor of LCS-1269 in the synthesis process.
The aim of the work was to identify impurities in the substance LHS-1C69, to confirm their structures and belonging to derivatives of indolo[2,3-a]carbazole.
The identification of impurities in the substance LCS-1269 was carried out using the HPLC-MSMS method. For this purpose, X and Y impurities having the assumed structures were obtained by directed counter synthesis, which were used as reference samples.
Comparison of peak retention times on extracted ion chromatograms (XIC) and MSMS spectra of impurities with XIC and MSMS spectra of samples of comparison of the alleged impurities confirmed their structure.
As a result of the work carried out, the structures of impurities X and Y were identified and the affiliation of these impurities to derivatives of indolo[2,3-a]carbazole was confirmed.
STUDY OF THE DISTRIBUTION OF GUANIDINE POLYMETHACRYLATE TO CREATE A NEW GENERATION OF NANOCONTAINERS THAT PROVIDE TARGETED DRUG DELIVERY TO TARGET CELLS
Authors: I.A. Miziev , S.Yu. Khashirova , R.A. Akhkubekov , A.F. Budnik , Z.O. Ivanova , L.V. Elgarova
Published: February 2023

Investigation of the distribution of guanidine polymethacrylate - as the basis for a future nanocontainer for targeted transport of drugs in living organs and tissues and assessment of its effect on the body as a whole. To assess the effect on the body and the distribution of PMAG in tissues and organs, we used 24 experimental healthy laboratory rats: identical in series, sex, weight and age. A solution of PMAG in 0.9% sodium chloride in three concentrations: 2.5 mg / ml, 5 mg / ml, 10 mg / ml was administered to rats intravenously. Pieces of organs and tissues were fixed in 10% neutral formalin and embedded in paraffin according to the generally accepted technique. Histological sections, 5-7 μm thick, were stained with hematoxylin and eosin. The preparations were examined under an OLYMPUS BX 43 microscope with a digital video camera. Intramuscular injection of nanomaterial causes structural changes in the intestinal wall of rats, which are manifested after the introduction of 1 ml of solution at a dosage of 2.5 mg / ml after two hours. Changes are manifested in circulatory disorders, leukocyte infiltration, degenerative changes and epithelial necrosis. Alterative changes increase as the concentration of the injected solution and the exposure time increase. The results obtained indicate that at this stage it is not yet possible to immediately use this material for targeted drug delivery, but further developments in this direction seem quite promising for the development of new therapeutic anticancer drugs, an innovative strategy for personalized molecular therapy for intestinal cancer.
Factors that Affect Efficiency in the Utilisation of Performance Management Data Sets at Tshwane University of Technology
Authors: Pieterse Magrietha Jacoba , Worku Zeleke , Muchie Mammo
Published: February 2023

The research explores the conflicts in the management information systems within the South African Higher Education Institutions (HEIs). Research done on the quality of data that has been assessed and evaluated is still very limited and scanty. This study aims to fill the gap by conducting an empirical study on the performance management data with a geographical demarcation by selecting a specific university of technology Tshwane University of Technology (TUT). An explanatory design was used to determine why there are so many data errors to discover and suggest solutions to the problem. The units of analysis are individuals. The reasons why individuals make mistakes and why from the on-set data is not captured accurately. This is a crosssectional study and data was collected from respondents over a period between two and seven months. Questionnaires were distributed over a period of seven months and interviews were conducted over a period of two months. The primary causes for inaccurate data are identified as data managers are not sufficiently trained; and staff members are not always aware of where he or she fits into the organization. Data capturers are not adequately trained to prevent data errors and a lack of communication also contribute to data errors. Research confirms that user resistance can cause the implementation of a new MIS system to fail. There is still a gap in understanding how users evaluate changes related to a new information system. It is further confirmed that there exists a relevance between colleques opinions, self-efficacy for change and user resistance (Kim & Kankanhalli, 2009). The following training modules are suggested to be included in the training programme: the importance of data accuracy and consequences of data errors; basic management skills, the value chain of the university as well as targeted training to address specific ITS data errors.
Teacher Narratives of Social (in)justice: Early Experiences Shaping Pedagogy
Authors: Limbada Zakeeya , Kajee Leila
Published: February 2023

This paper explores a sample of English language teachers’ perceptions and practices of social justice in Johannesburg, South Africa. These teachers teach substantial numbers of learners who are not mother tongue speakers of English, learning exclusively through an English medium. This accounts for injustices that face learners regarding access to and performance in education. These learners are of various linguistic backgrounds and require support to meet the basic promotion and pass requirements for English proficiency. Guided by critical pedagogy, social justice education and multilingualism, this study explored teachers’ narratives of their experiences of justice/injustice. In examining teachers’ narratives this study explored whether these experiences of justice/injustice shaped teachers’ perceptions of social justice and if teachers actively took up positions as agents of change through their teaching practices. Using a qualitative exploratory case study method, data in the form of written narratives was elicited from ten English teachers from two secondary school sites. This study found that teachers’ views, values, and attitudes were shaped by their own experiences of injustices and marginalization. All teachers believed they play a critical role in the personal and academic growth of their learners and acknowledged the potential role they possibly play as agents of individual and social transformation. Curriculum demands and contextual factors for some made the enactment of social justice pedagogy challenging. Language was highlighted as a key area where learners were disadvantaged in the learning process and further support was needed.
Factors Influencing Digital Customer Experience Transformation in the Retail Industry
Authors: Mamhiyo Godwill , Jokonya Osden
Published: February 2023

Retailers are losing ground to fellow competitors as they fail to meet customer expectations. With customers spread across multiple markets, locations, and platforms, having the right product at the right time has never been more important. This study investigates the technological, organisational, and environmental (TOE) factors that influence digital supply chain. The study adopted systematic literature review to explore factors that influence digital customer experience transformation in the retail industry. The systematic literature review used content analysis to assess 80 published articles on digital customer experience from 2014 - 2019. The study adopted the TOE framework as a lens to explore factors that influence digital customer experience transformation in the retail industry. The results indicated that all three TOE framework factors influence digital customer experience transformation in the retail industry. The study results suggest that retailers must consider the possible impact of the technology based organisational and environmental factors. The study contribute to the body of knowledge to the factors that influence digital customer experience transformation in the retail industry.
Factors Affecting Digital Transformation in the Retail Supply Chain
Authors: Daniels Nuraan , Jokonya Osden
Published: February 2023

The digital transformation, introduced by the fourth industrial revolution, has significantly transformed the value proposition of supply chain organisations. However, there is limited extant literature based on factors that influence the adoption of digital supply chain within the retail industries. The objective of the study was to explore the factors that influence digital transformation in retail supply chain. The study adopted systematic literature review of all pertinent articles, published during the period 2010-2019. The study adopted Technology-Organizational-Environmental (TOE) framework as a lens to explore factors that influence the adoption of digital supply chain within the retail industries. The study results suggest that most technological factors influence the adoption of digital supply chains within the retail industries compared to organisational and environmental factors. The study contribute to the body on knowledge on the factors that influence the adoption of digital supply chain within the retail industries.
Updates in Luxury Purchase Motivation in East Asia: China, Japan & South Korea
Authors: Che Manyu , Hou Qianxi , Wang Haoyu , Coste-Manière Ivan , Le Troquer Francois
Published: February 2023

Japan and South Korea have always had an important influence in the East Asian luxury goods market. In recent years, Chinese consumers have also arisen extensive attention from luxury brands and consumer markets in various countries. Although the three countries have the common Confucian and Zen culture which brought a certain degree of commonalities, such as collectivism and aesthetic preferences, at the same time, they have developed their own national characters, such as China's "benevolence", Japan's "loyalty" and South Korea's "righteousness"—accompanying the evolution of aesthetic consciousness in the thousands of years' history, all of these impact profoundly on today's consumer motivation. However, the international and national economy, politics, society and communication gradually evolved different consumption motivations. "Luxury" has undergone tremendous changes among consumers in the three countries. A total of 405 respondents (of which 325 respondents answered all questions) in the three countries received our questionnaire. The questionnaire contained two parts: basic information and consumption motivation, based on the impression of the word "luxury" and the 36 questions which divided into five levels (Strongly Agree, Agree,Neutral, Disagree, Strongly Disagree). Impression keywords helped us to understand the changes in consumers' attitudes towards "luxury". Besides, we analyzed 36 consumer motivations and behaviour issues through relative importance index (RII) analysis and classified and grouped these factors to determine the importance of motivation ranking. The results show that Chinese consumers are more concerned about the practical value of luxury goods, such as quality and price. Japanese consumers regard craftsmanship and quality as the most important consumption motives, while pleasure and quality are factors that Korean consumers value more. Through the analysis of the results, combining with the uncertainty caused by the Covid-19 epidemic this year, we could see that luxury brands not only need to strengthen customer relationship management, but also consumer segmentation, behaviour and sentiment analysis, as well as the predictive analysis in order to provide customers with personalized, high-quality services. At the same time, as ethics and sustainable values become more and more important in consumer awareness, and even affect their purchasing decisions, they hope that the brands they buy can reflect their own value. Therefore, how to use science and technology to enhance transparency and authenticity will also be the new focus of luxury brands.
The Impact of Gendered and Gender-Neutral Communication on Brand Equity: A Study on Children Apparel Industry
Authors: Coggiola Matteo , Coste-Manière Ivan
Published: February 2023

This work wants to analyze the impact of communication on Brand Equity, comparing a gendered and an ungendered type of advertising relative to a brand of children apparel. The idea of this work comes from the acknowledgment that, to the current situation, there is little research on the pro/cons of the usage of a type of communication alternative to the traditional one and free of gender stereotypes, and on its objective consequences on brand dimensions. The study was conducted using posttest-only control group design: participants were randomly assigned to two groups, control and intervention, and were presented with two different stimuli (a gendered and a gender-neutral one). Convenience sampling has been adopted for this research and an online close-ended response questionnaire was used for data gathering. A total of 152 responses were ultimately used in the study. The study challenges the argument that gender stereotypes are efficient tools to be used in communication to elicit a positive response and generate clearer brand associations in the viewer. The results showed how a gender-neutral type of communication has an overall positive effect on Brand Equity dimension, and how this result varies according to the age range of respondents.
Dampak Pelatihan Pembuatan Pupuk Bokashi Untuk Petani Cabai Merah
Authors: Wardah Eva , Maisura Maisura , Budi Setia
Published: February 2023

This study aims to determine the impact of training to produce Bokashi fertilizer including; 1) the ability of red chili farmers as participants to identify raw materials to make Bokhashi fertilizer, 2) the farmers understand the benefits of Bokashi fertilizer in red chili cultivation, 3) the farmers are able to make Bokashi fertilizer, 4) farmers familiar how to apply Bokashi fertilizer in the red chili cultivation, (5) farmers have a desire to apply Bokashi fertilizer to the red chili cultivation. The research method is qualitative descriptive which measures the impact of implementing Bokashi fertilizer training by comparing the initial evaluation (pretest) with the final evaluation (posttest) of the knowledge, skills, and attitudes of farmers towards Bokashi fertilizer training. The results of the study indicate the impact of increasing aspects of knowledge, skills, and attitudes of participants from the indicators assessed in this research activity. It is expected that the government and other empowerment parties will provide a variety of empowerment methods (a combination of training and mentoring) to increase the knowledge, skills, and attitudes of farmers in farming chili
Aksi Kolektif Petani Dalam Koperasi Untuk Agribisnis Berkelanjutan
Authors: Hariance Rika
Published: February 2023

Social exchange assumes social behavior is an exchange series where individuals always try to maximize the benefits they get and minimize the costs or risks incurred. The social exchange theory is perfected with network theory (social exchange theory), which is that social exchange does not only occur between two people (individuals and individuals), but occurs by involving various parties, agencies, and organizations. This study aims to describe the collective action in agribusiness partnerships that have been carried out by several previous researchers. The method used in this research is a literature study by looking at patterns and symptoms from previous research. This research tries to complete an important part in a cooperative namely collective action as a basis for the establishment of cooperatives.
Pengembangan Kewirausahaan Agribisnis Melalui Pelatihan Kelompok Usaha Hidroponik
Authors: Fadli Fadli , Suryadi Suryadi , Kembaren Emmia Tambarta
Published: February 2023

ABSTRAKPeningkatan jumlah penduduk di Aceh Utara menyebabkan keterbatasan lahan produktif untuk menunjang kebutuhan sayuran. Kebiasaan menggunakan pupuk kimia juga menyebabkan penurunan kualitas  tanah baik secara fisik, kimia maupun biologi. Hal tersebut berdampak pada berkurangnya luas lahan yang dapat dijadikan sentral produksi pertanian khususnya komoditi hortikultura (sayur-sayuran). Permasalahan ini merupakan suatu peluang tersendiri untuk bidang Agribisnis yang membahas pertanian dari hulu ke hilir. Kegiatan pengabdian masyarakat ini bertujuan untuk mengembangkan jiwa kewirausahaan melalui kegiaatan budidaya sayur Hidroponik yang dikelola dalam manajemen kelompok secara produktif dan berkelanjutan, memunculkan ide untuk menciptakan lapangan pekerjaan dan kesempatan berusaha di bidang sayur-sayuran bagi generasi muda, mengoptimalkan pemanfaatan potensi teknik budidaya sayuran hidroponik untuk mengatasi potensi keterbatasan lahan serta  mampu meningkatkan supply hortikultura di Aceh Utara. Pengembangan Kewirausahaan Agribisnis melalui pelatihan kelompok usaha hidroponik merupakan pengenalan komoditi yang potensial untuk jenis teknik budi daya hidroponik. Sebagian besar masyarakat muda di daerah penelitian memiliki waktu luang yang bisa digunakan untuk melakukan aktivitas tertentu sehingga memberikan keuntungan bagi mereka seperti membudidayakan tanaman hidroponik. Melalui pelatihan ini mereka diharapkan mampu meghasilkan usaha hidroponik yang dapat meningkatkan pendapatan dan  kesejahteraan
Analisis Usaha Ternak Ruminansia di Nagari Silokek Kabupaten Sijunjung
Authors: Novarista Noni , Maiyontoni Maiyontoni , Putra Riza Andesca , Triani Hera Dwi
Published: February 2023

Penelitian ini bertujuan untuk mendeskripsikan: 1) Karakteristik peternak sapi, kerbau dan kambing dan 2) Aspek teknis usaha peternakan sapi, kerbau dan kambing   di Nagari Silokek Kabupaten Sijunjung. Penelitian ini menggunakan metode survey dengan memakai data primer dan sekunder. Jumlah responden dalam penelitian ini sebanyak 10 orang peternak. Data dianalisis secara deskriptif kuantitatif. Hasil penelitian menunjukkan: 1) Karakteristik peternak sapi, kerbau dan kambing di Nagari Silokek: a) umur peternak umumnya berusia produktif (25-55 tahun), b) jenis kelamin sebagian besar adalah laki-laki, c) tingkat pendidikan   peternak   sebagian  besar  berpendidikan  rendah,   d)  pengalaman beternak tergolong baru untuk ternak sapi (66,7%) dan sudah beternak lama untuk ternak kerbau dan kambing (50% dan 100%), e) jumlah kepemilikan ternak masih skala kecil untuk ternak sapi dan kerbau (66,7% dan 50%) dan skala besar untuk ternak kambing, f) status usaha ternak sebagian besar masih usaha sampingan untuk ternak sapi dan kerbau, untuk ternak kambing sudah sebagai usaha utama (50%). 2) Aspek teknis usaha peternakan sapi, kerbau dan kambing di Nagari Silokek: a) bibit yang digunakan adalah bibit yang ada di sekitar lokasi/turun temurun dan dipilih dengan pengetahuan tradisional, b) pakan yang diberikan hanya rumput yang didapat ternak dari hasil merumput dan ditambah dengan yang diberi peternak, c) sistem pemeliharaan ternak kerbau dilepaskan saja, ternak sapi dilepaskan di siang hari dan dimalam hari dikandangkan, ternak kambing dipelihara secara intensif (dikandangkan).