bluuebunny/crossref_metadata_2025 huggingface dataset:
A review of the spider genus Calamoneta Deeleman-Reinhold, a new genus in the Western Pacific and the genus Eutittha Thorell (Araneomorphae: Cheiracanthiidae)
Authors:   Queensland Museum, Raven Robert , Hebron Wendy
Published: August 2024

The genus Calamoneta Deeleman-Reinhold is reviewed; four new species are described: Calamoneta cullenae sp. nov. and Calamoneta micrognatha sp. nov., from north Queensland, Calamoneta eungella sp. nov. from mid-eastern Queensland and Calamoneta flavigena sp. nov. from south-eastern Queensland. Cheiracanthium longimanum L. Koch, 1873 from Fiji, Samoa and Tonga is transferred to a new sister genus, Fijimoneta gen. nov., type species Fijimoneta vitilevu sp. nov. from Fiji. Australian species in Cheiracanthium are briefly reviewed and Cheiracanthium pallidum Rainbow, 1920 is transferred to Gnathopalystes in the Sparassidae. The resurrection of Eutittha Thorell, 1878 is rejected.
Interview: Deciphering the Law: Hachette v. Internet Archive Pt. 1 (2023) with Dave Hansen
Authors: Hansen Dave , Taylor Tucker , Lewis Mariah
Published: August 2024

This is the first in a series of interviews with those closely tied to the Hachette v. Internet Archive lawsuit. In March 2023, the court ruled against the Internet Archive and its use of the Emergency Lending Library causing a ripple throughout the library and education fields. Below, find the answers to some of the questions that the case elicited by JCEL contributors and copyright scholars Dave Hansen, Michelle Wu, and Kyle Courtney.
Potential distribution of the Long-tailed Rattlesnake, Crotalus stejnegeri Dunn 1919 (Squamata: Viperidae): A rare and under-sampled species
Authors: Castro Bastidas Héctor Alexis
Published: August 2024

This study employed the MaxEnt algorithm to assess the potential distribution of the Long-tailedRattlesnake (Crotalus stejnegeri), a threatened species endemic to Mexico. The results demonstrate a high reliability ofthe model, achieving an AUC of 0.879. They highlight a potential distribution concentrated in habitats characterizedby tropical dry forest in the foothills of the Sierra Madre Occidental, primarily in south-central Sinaloa, southwesternDurango, and northern Nayarit. Temperature during the driest quarter and the seasonality of precipitation were identifiedas determining factors of habitat suitability, whereas the low suitability in Chihuahua suggests a tropical affinity ofthe species. Variability in precipitation during the coolest quarter emphasizes the importance of expanding the numberof occurrence records for the species by means of further field surveys within its known and potential range. Thesefindings provide valuable information for conservation efforts and identify key areas for future research.
The comparison of erector spinae plane block and caudal block for postoperative analgesia in paediatric surgery - meta-analysis
Authors: Purnama Adhi Mahendratama , Hardian Rapto , Budiman Susatya Arif , Elizeus Elizeus , Utariani Arie
Published: August 2024

Aim To assess the efficacy of Erector Spinae Plane Block (ESPB) compared to caudal block in reducing postoperative pain in paediatric surgery.
Methods An electronic literature search was conducted using the Cochrane Library, PubMed, and Google Scholar databases, with data collected from January 2018 until September 2023. This meta-analysis includes English-language randomized controlled trials (RCTs) studies contrasting ESPB with caudal block in paediatric patients. The primary outcome was the 24-hour postoperative pain scores. The secondary outcome included the time to rescue analgesia, the number of patients requiring rescue analgesia, and the occurrence of postoperative nausea and vomiting (PONV) and urinary retention.
Results Five RCTs with 295 samples were included. The results showed no significant difference between ESPB and caudal block in postoperative pain scores at 1st hour SMD (standardized mean difference)  of  -0.17 (95% CI -0.70, 0.36; I2=76%; p= 0.53), 2nd hour of SMD: -0.50 (95% CI -1.21, 0.21; I2=88%; p=0.17), 6th hour SMD -1.09 (95% CI -2.21, 0.03; I2=95%; p = 0.06), 12th hour SMD -0.77 (95% CI -1.75, 0.21; I2=93%; p=0.12), and the 24th hour SMD -0.13 (95% CI -0.39, 0.12;, I2=2%; p=0.30) were found. Furthermore, there was no significant difference in the time first to rescue analgesia, the number of patients requiring analgesia rescue, PONV occurrence, and urinary retention.
Conclusion ESPB and caudal block showed equivalent analgesia efficacy and safety in paediatric surgery.
Flu seasons during the period 2018-2023 in Sarajevo Canton, Bosnia and Herzegovina: possible impact of the SARS-CoV-2 pandemic on the influenza A and B virus circulation
Authors: Moro Almedina , Dedeić Ljubović Amela , Zahirović Edina , Mutevelić Selma , Arapčić Suzana , Čerkez Goran , Salimović-Bešić Irma
Published: August 2024

Aim During the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many countries reported a significant decrease in the prevalence of influenza virus cases. The study aimed to characterize the flu seasons from 2018 to 2023 in Sarajevo Canton, Bosnia and Herzegovina (B&H), and to assess the possible impact of the SARS-CoV-2 pandemic on the influenza A and B virus circulation. 
Methods The CDC Human Influenza Virus Real-Time RT-PCR Diagnostic Panels were used for the detection of influenza virus A and B, and subtyping of influenza virus A (H1pdm09 virus and H3). The data for this regis-try-based retrospective study were collected at the Clinical Centre of the University of Sarajevo, Unit for Clinical Microbiology (the laboratory that acts as a referral for the detection and characterization of influenza virus and SARS-CoV-2 in Federation B&H).
Results In the 2018/2019 and 2019/2020, an equal percentage of positive cases was recorded (148/410; 36%, and 182/504; 36%, respectively). The absence of the influenza virus was observed in 2020/2021. During 2021/2022, influenza virus was detected among 19/104 (18%) patients and slightly increased in 2022/2023 (45/269; 17%). The switch of the influenza B virus lineage was observed.
Conclusion The SARS-CoV-2 virus had an impact on the prevalence of influenza virus infection among the population of the Sarajevo Canton, B&H. Since the interactions between these two viruses are not entirely clear, awareness of a possible threat to public health is crucial.
Association of overexpression of PLD6, CHRAC1 and PDCD5 with type 2 diabetes mellitus
Authors: Adel Dawood Ali , Kays Omer Zayd , Farouk Al-Omari Alyaa
Published: August 2024

Aim Diabetes type 2 (DT2) is a metabolic disease characterized by high blood sugar caused by insulin resistance and/or insufficient insulin production. The pathogenesis of DT2 is complicated by both genetic predisposition and environmental and lifestyle variables. At least 150 genetic variants have been linked to the probability of having DT2. The aim of this study was to determine the expression of PLD6, CHRAC1, and PDCD5 genes in type 2 diabetic patients. 
Methods Information on 12 DT2 patients was obtained from the Gene Expression Omnibus (GEO) using the series identification (ID) (GSE34008). The analysis tools GEO2R, String Utils (STRING), University of Alabama at Birmingham Cancer data analysis (UAL-CAN), and the Cancer Genome Atlas (TCGA) were used. The human protein atlas provided details on gene cancer.
Results Only ten genes with expression differences ranging from low to high were selected. PLD6, CHRAC1, and PDCD5 were detected to have higher expression in patients compared to controls. The number of patients with primary pancreatic adenocarcinoma for SLC16A4, DERK2, and CHRAC1 was greater than that of healthy controls. Concerning the severity of cancer, all chosen genes demonstrated a greater proportion of affected individuals compared to the control group. 
Conclusion There are multiple genes whose increased expression is linked to type 2 diabetes.
Clinical outcome of surgically treated displaced acetabular fractures with central dislocation using combined anterior and medial plating
Authors: Radaideh Ahmad , Alansari Abu Tabar Malik , Mohaidat Ziyad , Alkhatatba Mohammad , A. Ahmed Marwan
Published: August 2024

Aim Acetabular fractures are complex articular fractures with a big challenge for orthopaedic surgeons. Surgically managed displaced fractures carry favorable outcomes, especially if the articular surface is reduced accurately. This study aims to assess the clinical outcomes of surgical-ly fixed displaced acetabular fractures with central dislocation using combined anterior and medial plating.
Methods We have retrospectively evaluated sixteen patients, who had surgically managed dis-placed acetabular fractures with central dislocation at our institute. All patients underwent open reduction and internal fixation using combined anterior and medial plating via the Kocher-Langenbeck, the ilioinguinal, or the Stoppa approach. The functional outcome was assessed using the Harris Hip score.
Results Our study includes sixteen patients (12 males, 4 females) with a mean age of 35 years (range: 15-53 years). The mean follow-up was 7.8 years (range: 5-13 years). Functional outcomes were good to excellent in 12 (80%) patients and fair in 3 (20%) patients. At the final follow-up, the solid union had been achieved in all fractures, the mean HHS was 88.84 ± 7.61.
Conclusion Early reduction and surgical fixation of dis-placed acetabular fractures with central dislocation using combined anterior and medial plates appear to have good clinical outcomes.
The influence of anthropometric parameters on the concentration of globulin that binds sex hormones during the menopausal transition
Authors: Softić Dženana , Mešalić Lejla , Softić Delila
Published: August 2024

Aim To determine the effect of body mass index (BMI) and waist-hip ratio (WHR) on the concentration of circulating sex hormone-binding globulin (SHBG) throughout the menopausal transition.
Methods This cross-sectional study included 150 women divided into three groups: premenopausal (n=50), perimenopausal (n=50), and postmenopausal (n=50). The processing of the test women consisted of three phases: inter-view, blood sampling and determination of BMI and WHR. The SHBG concentration was determined from the blood, and BMI and WHR were measured.
Results The BMI and WHR of the post-menopausal women were significantly higher comparing to the other two groups, while the postmenopausal SHBG was significantly lower compared to the premenopausal con-centration. In all three groups, a significant negative correlation was found between SHBG and BMI (Rho= -0.385; p<0.05), and between SHBG and WHR (Rho= -0.411; p<0.05). By the univariate regression analysis model, it was determined that BMI (β= -0.594; p<0.001) and WHR (β= -0.407; p=0.003) were independently negative predictors of SHBG in postmenopausal women, while in the multivariate regression analysis model only BMI as an independently negative predictor of SHBG in postmenopausal women was found (β= -0.263; p=0.024).
Conclusion The value of SHBG during the menopausal transition decreases and women with higher BMI and WHR have lower values of SHBG regardless of the duration of menopause. 
Considering the connection between SHBG and anthropometric parameters, and the drop in its values upon entering and passing through the menopausal transition as such it can be used as a predictor for an increased risk of cardiovascular diseases and metabolic syndrome in a selected group of women.
Synergistic Developmental Toxicity and Apoptosis of BPA and Zn Co-Exposure in Daphnia magna
Authors: Hamid Naima , Arifin Aishah Binti , Ong Meng Chuan
Published: August 2024

The combined effects of chemical pollutants in the aqueous environment create inevitable impacts on aquatic ecosystems. Bisphenol A (BPA) is identified as a chemical pollutant of significant concern, primarily owing to its pronounced toxicity in the freshwater environment. Similarly, essential elements like zinc (Zn) may induce toxic effects upon alterations in their metal speciation, leading to increased bioavailability. Therefore, the present study aimed to elucidate the developmental toxicity effects using fresh water model Daphnia magna. Using environment-relevant BPA (10 µg/L and 20 µg/L) and Zn (10 µg/L and 30 µg/L) levels were exposed to Daphnia magna for 48 h to determine the acute toxicity. Results showed that maximum mortality (40%) was observed at a high exposure dose of BPA and Zn at 48 h. Similarly, a significant dose-dependent reduction in heartbeat and body weight was found in all samples. Blood clotting, broken antenna, missing tail changes in the carapace, and bioaccumulation, were the dominant morphological changes in all treatments. These findings were confirmed with the elevated apoptosis at the second antenna, gut, and post-abdominal regions after high-dose treatment. Spearman correlation analysis showed a significant positive correlation (R2 = 0.86) between mortality and deformity ratio indicating high joint toxicity of BPA and Zn. Lastly, more in-depth studies are required to highlight the combined toxicity of the BPA and Zn and ensure ecological integrity.
Genome Sequencing and Phylogenetic Analysis of SARS-CoV-2 Isolated from Patients with COVID-19 in Hospital Canselor Tuanku Muhriz (HCTM), Malaysia
Authors: Wong Kon Ken , Zainol Rashid Noor Zetti , Ali Umi Kalsom , Chong Nur Hazlin , Abdul Razak Shairah , Kori Najma , Periyasamy Petrick , Hanafiah Alfizah
Published: August 2024

SARS-CoV-2 infection has reached pandemic status in numerous countries worldwide, including Malaysia. Monitoring the genetic diversity of SARS-CoV-2 is essential for identifying the emergence and prevalence of novel variants in different geographical areas. From May to October 2021, this research endeavor analyzed the SARS-CoV-2 genome of 40 COVID-19 patients diagnosed using real-time RT-PCR at the local hospital HCTM-UKM. The process involved extracting RNA from these patients, which was subsequently subjected to whole genome sequencing. Our discovery underscores the primary strains responsible for the fourth wave of the COVID-19 pandemic in Malaysia in May 2021 were the Beta variant, primarily associated with the B.1.351 lineage. However, by October 2021, the Delta variant had become predominant and was categorized within the AV.59 and AV.79 lineages. Genomic epidemiological analysis showed about 19 amino acid mutations in the spike protein that were prevalent during the Beta variant outbreak. Among these, the N501Y mutation is particularly noteworthy as it significantly enhances the virus's ability to bind to the ACE2 receptor. Additionally, 32 amino acid mutations were identified during the Delta variant outbreak, with the T478K mutation being linked to increased viral infectivity and affecting the virus's affinity for human cells. Throughout our research, we consistently noted the presence of Spike D614G mutations in all the strains we collected which is known to reduce S1 shedding and increase infectivity. These findings could contribute significantly to our understanding of specific variants due to their clinical implications and rapid spread within the community.
Faktor yang mempengaruhi Pengurusan Risiko Keselamatan di Makmal: Kajian Kepustakaan Sistematik
Authors: Kamaruddin Zuraida , Isa Zaidi , Jamaan@Sharman Saiful Hafizah
Published: August 2024

Pengurusan risiko keselamatan merupakan aspek kritikal dalam makmal kejuruteraan disebabkan oleh uji kaji yang kompleks dan kemunculan teknologi terkini yang meningkatkan risiko kemungkinan berlakunya kemalangan. Kajian kepustakaan sistematik ini melibatkan 23 artikel yang mematuhi garis panduan PRISMA dan mengkategorikan faktor yang mempengaruhi protokol keselamatan. Kajian ini memfokuskan kepada persoalan kajian iaitu apakah faktor utama yang mempengaruhi amalan pengurusan risiko keselamatan di makmal kejuruteraan dan bagaimanakah faktor ini mempengaruhi persekitaran keselamatan di makmal? Melalui penyelidikan ini, faktor penyumbang telah dikenal pasti dan dikelaskan ke dalam lima tema utama: 1) Protokol Pengurusan Risiko, 2) Faktor Organisasi, 3) Faktor Fizikal dan Persekitaran, 4) Faktor Luar dan Kontekstual dan 5) Hala Tuju Inovatif Baharu. Bidang ini mempengaruhi tindakan keselamatan dengan cara yang kompleks. Hasil kajian ini memaparkan protokol keselamatan yang berkesan, integriti organisasi, pematuhan peraturan dan strategi keselamatan yang inovatif. Pemahaman yang lebih mendalam ini meningkatkan langkah keselamatan, mengurangkan kemalangan, memacu budaya mengutamakan keselamatan dan menjamin pematuhan keselamatan. Kajian ini secara signifikan menyumbang kepada pengetahuan saintifik tentang pengurusan risiko keselamatan di makmal kejuruteraan, menangani keperluan kritikal untuk melindungi kesejahteraan manusia dan alam sekitar.
Penyediaan Aerogel Terubah Suai Polivinil Alkohol/Selulosa Mikrohablur Sebagai Pemisah Minyak/Air
Authors: Saiful Hishah Muhammad Faris , Safar Hasan , Ahmad Ishak
Published: August 2024

Insiden tumpahan minyak memberi kesan yang buruk terhadap alam sekitar, terutamanya kepada ekosistem hidupan akuatik yang seterusnya akan menjejaskan kesihatan manusia. Aerogel yang telah diubah suai mempunyai potensi untuk dijadikan sebagai bahan pemisah minyak dan air. Pengubahsuaian terhadap permukaan aerogel menjadikan sifatnya berubah kepada oleofilik dan hidrofobik yang amat membantu dalam proses resapan minyak sekali gus menghalang kemasukan air ke dalamnya. Penyelidikan ini dijalankan untuk menghasilkan aerogel PVA/MCC serta mengkaji potensinya sebagai pemisah air/minyak. Selain itu, kajian ini turut dilakukan untuk meneliti kesan kandungan MCC terhadap sifat hidrofobik dan mekanikal aerogel PVA/MCC. Aerogel dihasilkan dengan menggunakan kaedah pengeringan sejuk beku, kemudian, permukaannya telah dirawat dengan silana melalui kaedah pemendapan wap kimia (CVD) untuk memberikannya sifat hidrofobik dan oleofilik. Berdasarkan analisis FTIR, kumpulan berfungsi silanol (Si-OH) yang memberikan sifat hidrofobik kepada aerogel telah dikesan. Berdasarkan pemerhatian mikroskopi imbasan elektron (SEM), peningkatan kandungan MCC kepada komposit aerogel PVA dapat meningkatkan keporosan aerogel dan membuatkan permukaannya semakin kasar. Kemudian, melalui analisis sudut sentuh dan ujian mampatan pula, aerogel yang mengandungi 8%MCC mempunyai sudut sentuh tertinggi iaitu 143.13° dan kekakuan yang tinggi. Akan tetapi, melalui keputusan analisis jerapan fizikal, aerogel yang ditambah dengan 4%MCC mempunyai luas permukaan dan jumlah isi padu liang tertinggi iaitu 2.1302 m2/g dan 0.002277 cm3/g. Malah, ia juga mempunyai kapasiti penyerapan minyak yang tertinggi, iaitu 0.55 g/g. Berdasarkan keputusan yang diperoleh, penambahan MCC telah meningkatkan potensi komposit aerogel sebagai pemisah minyak dan air.
Microwave vs. Reflux Synthesis of Bis-Thiourea Derivative: Yield Optimization, Crystallographic Understanding and Optical Sensing Potential
Authors: Salah Naeem Hasanain , Jaber Israa , Sapari Suhaila , Abdul Razak Fazira Ilyana , Majid Rudaini Bilal , Abd Razak Nurul Hidayah , Soheil. Najm Asmaa. , Hasbullah Siti Aishah
Published: August 2024

A new bis-thiourea (BT) derivative was successfully synthesized using both conventional reflux and microwave irradiation methods. The microwave irradiation reaction yielded a greater percentage yield of 73%, while the reflux heating yielded only 44%. The microwave irradiation procedure takes a minimum of 10 min to complete, in contrast to the reflux heating method, which takes 24 h. The compound was characterised using a variety of spectroscopic techniques, including UV-Vis, FTIR, nuclear magnetic resonance (1H-NMR and 13C-NMR), and single crystal X-ray crystallography (XRC). It shows that BT has a high ability to form hydrogen bonds of both intermolecular and intramolecular types, as demonstrated by X-ray crystallography and DFT calculations. In addition, this research provides insights into the possible uses of BT in coordination chemistry involving metal ions, such as a copper ions. Through the use of density-functional theory (DFT) and UV-Vis investigations, it is envisaged that the BT compound has a strong tendency to form stable copper ion complexes. This is supported by the optimal energy value E(UB3LYP) observed for the Cu(II) complex.
Clinical Significance of Ikaros in Systemic Lupus Erythematosus (SLE): A Systematic Literature Review
Authors:   Rheumatology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia.
Published: August 2024

Systemic lupus erythematosus (SLE) is a multi-systemic chronic autoimmune disease. Ikaros is a family member of transcription factors, encoded by the Ikaros family zinc finger 1 (IKZF1) gene. It is important in hematopoiesis and immune system regulation as it helps in lymphoid cell differentiation. Ikaros functions in the pathogenesis and therapeutic target in SLE are well demonstrated in mice. This systematic review highlighted the clinical significance of Ikaros and IKZF1 in SLE patients via a comprehensive search using OVID, PubMed, and Cochrane databases. The following terms “SLE”, “lupus”, “Ikaros transcription factor”, “Ikaros zinc finger” and “IKZF” were searched and all of the relevant publications were scrutinised. Only human studies were included. A total of 22 relevant publications of Ikaros in SLE patients were included. IKZF1 polymorphisms were demonstrated to be significantly associated with SLE across different ethnicities of SLE. This association had led to clinical trials in SLE, using iberdomide that targets Ikaros. However, studies on the Ikaros gene expression and protein levels were found to be conflicting in SLE, which suggested clinical heterogeneity of the disease. In conclusion, further studies are needed to determine the exact effects of Ikaros and which subtypes of SLE patients will benefit from treatment.
Outcome of Patients with Traumatic Brain Injury Admitted to ICU UKMMC: A 5-Year Retrospective Study
Authors:   Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
Published: August 2024

Traumatic brain injury (TBI) has led to significant morbidity and mortality worldwide, imposing a substantial burden socioeconomically. Development and adherence to management guidelines has shown promising results in improving the outcomes of patients with TBI, in both mortality as well as functionality. Nevertheless, a protocolised management guideline remains lacking in many centres in Malaysia. This single-centre retrospective study aimed to determine the outcomes of patients with TBI admitted to Intensive Care Unit (ICU) and the associated risk factors. Additional work had been done to follow up on the employment status of these patients. ICU registry was screened for eligible patients with TBI admitted 2015-2019, and relevant information were extracted. Logistic regression was used to determine risk factors. McNemar test was used to analyse post-traumatic employment status of patients. A total of 173 patients were studied, and all-cause mortality of 16.2% was reported. Increasing age, occurrence of hypoxaemia and hypotension respectively during the first 24-hour in ICU, and higher lactate level were independent risk factors to mortality. As many as 40.9% of patients who were employed or was a student prior to TBI, did not return to work/school. We concluded that the in-hospital mortality for patients admitted to ICU for TBI was high. Unemployment after TBI is high, however, it is not directly attributed by functional disability following the injury.
Factors Associated with Past 12-month Quit Attempt of Electronic Cigarette Use in Malaysian Adults
Authors:   Centre for Community Health Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia
Published: August 2024

Relative to quitting cigarette smoking, quitting electronic cigarettes (EC) has been understudied in Malaysia. This study aimed to identify the prevalence and factors associated with an EC quit attempt in the past 12 months. In a cross-sectional online questionnaire survey, adults aged between 18 to 44 years old who had ever used EC were purposively recruited. A perception questionnaire about the benefits, harms and side effects of electronic cigarettes, as well as the Fagerström Test for Nicotine Dependence, Glover-Nilsson Vaping Behavioral Questionnaire, and the Minnesota Nicotine Withdrawal Scale were self-administered. Crude and adjusted odds ratios were computed using binary logistic regression with past 12-month quit attempt as the dependent. Our study found that more than one-third of our participants (37.0%) had tried quitting EC in the past 12 months. Higher motivation to stop vaping, younger age, younger age at EC use initiation and younger age when starting daily EC use were associated with higher odds of past 12-month quit attempt. Our findings offered insight in profiling EC users that may assist in helping them quit. Health literacy implemented on younger individuals may be key to reduce disparities in terms of education where it comes to stopping EC use.
Marrow Fibrosis in Epstein-Barr Virus Infection, Masking Preleukaemic Phase of Acute Lymphoblastic Leukaemia: A Case Report
Authors:   Department of Pathology, Hospital Tuanku Ja’afar, Jalan Rasah, Bukit Rasah, 70300 Seremban, Negeri Sembilan, Malaysia
Published: August 2024

Preleukaemic phase of acute lymphoblastic leukaemia (ALL) is a rare occurrence that might affect children and adolescent. Typically, it is characterised by pancytopenia and bone marrow hypoplasia, followed by a leukaemic phase in peripheral circulation within 2 years’ time. We herein reported a case of marrow fibrosis in a 25-year-old patient with Epstein-Barr Virus (EBV) infection, whom presented with fever and incidental findings of pancytopenia. He was later found to have ALL when his peripheral blood findings showed neutropenia with presence of 59% blasts after 3 months of presentation. This case highlighted the importance of close monitoring of pancytopenia cases with non-specific findings in bone marrow examination. A repeat bone marrow examination should always be considered for cases with persistent unexplained pancytopenia, to allow early detection of overt ALL without delay.
Genç Sporcularda Ebeveyn Desteği Ölçeği: Geçerlik Güvenirlik Çalışması
Authors: Görgülü Recep , Şenel Ender , Akgül Aygün , Oruç Hilal , Menteş Görkem , Salman Kaan
Published: August 2024

Genç sporcularda ebeveyn desteği süreç içerisinde karşılaşılan zorlukların üstesinden gelmek ve sporcuların gelişim süreçlerine olumlu katkı sağlamak için son derece önemlidir. Mevcut alanyazında yapılan araştırmalar ebeveyn desteği kavramını psiko-sosyal açıdan farklı boyutlarda incelemiş olmasına rağmen, spora özgü psikolojik boyutlarda kuramsal alt yapısı oluşturulan mevcut tek bir ölçüm aracı olarak ‘’Genç Sporcularda Ebeveyn Desteği Ölçeği (GSED-Ö)’’ Burke ve diğerleri (2023) tarafından geçerli ve güvenilir bir ölçüm aracı olarak geliştirilmiştir. Bu çalışmanın amacı Burke ve diğerleri (2023) tarafından geliştirilen GSED-Ö’nün Türkçe formunun geçerlik ve güvenirliğinin genç sporcularda test edilmesidir. Çalışmanın örneklemini 5 farklı branşta yer alan ve yaşları 11 ile 17 arasında değişen toplam 300 (x_yaş= 14,41 ± 1,81; 110 kadın ve 190 erkek) aktif spor yapan katılımcı oluşturmaktadır. GSED-Ö 18 madde 4 alt boyuttan oluşan beşli Likert tipi bir ölçektir. Genç sporcuların, spor branşları ile ebeveynleri tarafından sağlanan destek, sırasıyla; duygusal destek, bilgi desteği, özerklik desteği ve araçsal destek olmak üzere toplam 4 alt boyutta değerlendirilmektedir. Uzman görüşleri sonrasında GSED-Ö’nün Türkçe formunun kapsam geçerliğinin uygun olduğu tespit edilmiştir. Doğrulayıcı Faktör Analizi sonuçlarına bakarak GSED-Ö’nün Türkçe forumunun orijinalindeki gibi duygusal, bilgi, özerklik ve araçsal destek olmak üzere dört boyutunu ortaya çıkararak, genç sporcuların ebeveyn desteği algılarını ölçmek için geçerli ve güvenilir bir ölçüm aracı olduğu söylenebilir. Gelecekte bu konuda araştırma yapmak isteyen araştırmacılar için, GSED-Ö genç sporcuların gelişim süreçlerinde ebeveyn desteğinin hangi boyutlarının düzenleyici etkilerinin olduğunu tespit etmede önemli bir ölçüm aracı olarak kullanılabilir.
OPTIMAL CONTROL HARMONY: NAVIGATING DETERMINISTIC AND STOCHASTIC REALMS WITH A TWO-STRAIN MODEL USING PONTRYAGIN’S MAXIMUM PRINCIPLE
Authors: Kayanja Andrew , Abola Benard , Kikawa Cliff R. , Oyo Benedict , Ssematimba Amos
Published: August 2024

In this paper, we study optimal control solutions using a two-strain SARS-CoV-2 deterministic epidemic model characterized by standard incidence, alongside a two-strain stochastic model incorporating a random transmission rate. We present proofs demonstrating the existence, uniqueness, and boundedness of a positive solution for any positive initial value for both models. An algorithm for simulating the ensemble average optimal control solution is introduced and its realism is compared to both stochastic and deterministic solutions. Additionally, we include graphical representations to illustrate the dynamics and outcomes of our models. Our findings suggest that ensemble average optimal control simulations may offer enhanced visualization and realism compared to both stochastic and deterministic solutions.
Comprehensive analysis of the role of NLRC5 in gastrointestinal cancer: a systematic review
Authors: Rahadiani Nur , Ghozali Mohammad , Dewi Dyah Laksmi
Published: August 2024

BackgroundGastrointestinal (GI) cancer is affecting millions of people globally, leading to high incidence and mortality rates and a heavy economic burden. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a family of cytosolic pattern recognition receptors that regulate host defense responses against microorganisms. Among these, NLR family CARD domain-containing 5 (NLRC5) is assumed to function as a regulator of proinflammatory responses to intracellular pathogens. NLRC5 has been known to regulate immune responses, although its association with cancer remains controversial. This systematic review aimed to explore the roles and functions of NLRC5 in GI cancers.
MethodsThree electronic databases, PubMed, Scopus, and ProQuest, were used for literature searching on March 18, 2024. From 921 articles found, 157 duplicates were removed, 671 were excluded based on title and abstract screening, and 84 were excluded based on full-text assessment, resulting in 19 articles included in this review.
ResultsElevated NLRC5 levels have been observed in tumor tissues compared to normal tissues across esophageal, gastric, colorectal, and liver cancers. NLRC5 is also associated with increased tumor cell proliferation, migration, and invasion. Cancer cell sensitivity to 5-fluorouracil chemotherapy was found to be negatively correlated with NLRC5 expression. NLRC5 expression levels and genetic variations were also associated with cancer susceptibility to chemotherapeutic drugs and cancer survival.
ConclusionNLRC5 potentially exhibits diverse functions in GI cancers, acting as a biomarker for diagnosis, disease progression, prognostic assessment, and determining therapeutic implications. Further investigations are warranted to explore these mechanisms and their potentials for the development of effective treatment of GI cancers.
Comparison of degree of endothelial dysfunction in diabetic patients with and without dyslipidemia
Authors: Veeranki Sandeesha , Kiran Ravi , Kiran Usha
Published: August 2024

Atherosclerosis in patients with type 2 diabetes is multifactorial. Among other factors, dyslipidemia and increased levels of oxidized LDL are important pathogenic mechanisms of endothelial dysfunction in patients with diabetes. Non-invasive method of assessment of endothelial function by brachial artery flow-mediated vasodilatation (FMD), provided an extremely useful tool for clinical application.

90 patients attending the medicine and endocrinology departments were included in the study. Informed consent was obtained from all the study subjects. Clinical examination: Blood pressure (BP) and body-mass index (BMI); biochemical assessment, which included fasting blood sugar (FBS) and post-prandial blood sugar levels; and comprehensive lipid profile. The brachial artery diameter was measured on B-mode ultrasound images. FMD was calculated. Severe endothelial dysfunction was defined as FMD < 4.5%, as has been described. Data were collected and managed on an Excel worksheet.

The average FMD among controls was 14.76±2.17%, and among diabetics was 7.17±5.1%. Within the dyslipidemia subgroup, FMD was markedly reduced with an average dilatation of 5.74±5.02. Severe endothelial dysfunction was prevalent in 26% of the diabetics. Endothelial dysfunction could not be demonstrated in controls. Among patients with diabetic dyslipidemia, the prevalence of ED was 41%.

The present study findings may have implications about the origins of vascular disease in type 2 diabetes as well as patients with dyslipidemia. The ultrasound assessment of arterial FMD responses might provide a valuable tool for risk stratification of patients with type 2 diabetes, especially for those with dyslipidemia.
Amynthas aspergillum (Perrier, 1872) (Clitellata, Megascolecidae) : A new addition to the South Asian earthworm fauna
Authors: Prasanth Narayanan Sasankan , Verma Harshita , Verma Akash Kumar , Thomas Ambattu Paili
Published: August 2024

The presence of the exotic and potentially invasive pheretimoid earthworm Amynthas aspergillum (Perrier, 1872) of the family Megascolecidae is reported for the first time from South Asia. Specimens were collected from Dehradun of the Uttarakhand state in the Western Himalayan biodiversity hotspot of India. This work provides the detailed description of the specimens collected along with figures. Besides, certain biological aspects are also discussed.
Digital Marketing & Regional Tourism – Opportunities for Rajasthan
Authors: Mehta Pallavi , Joshi Pooja
Published: August 2024

Introduction: The digital era has brought significant changes to the tourism industry. This study examines the influence of digital marketing campaigns on regional tourism in the state of Rajasthan, India. Using a descriptive research methodology, the study aims to assess whether digital marketing is an appropriate tool for promoting Rajasthan's regional tourism offerings.
Methodology: The researchers conducted a primary survey and statistical analysis to test their hypotheses. This is a quantitative research study aimed at assessing the influence of digital marketing on promotion of regional tourism in Rajasthan.
Main Findings: The key findings suggest that gender does not significantly impact tourist satisfaction with the information available on digital marketing platforms about regional tourism. However, the data also indicates that digital marketing campaigns may not be the most effective approach for promoting regional tourism in Rajasthan.
Implications: The researchers recommend that the government should make greater efforts to identify the most appropriate digital marketing tools for showcasing Rajasthan's rich heritage, culture, historical sites, and other attractions.
Novelty: The study provides valuable insights into the role of online and social media marketing in the tourism industry. It highlights the need for destinations to carefully evaluate which digital channels and campaigns will be most impactful for promoting their unique regional tourism offerings.
Labor Market and Occupation in Russia: Problems and Prospects
Authors:   Junior Research Scientist of the Department of Constitutional, Zimakova Maria A.
Published: August 2024

The articleanalyzes various approaches to the definition of employment of the population, based on the characteristics of various theories of employment. Special attention is paid to the factors that should be taken into account when defining employment in Russia, such as the form of employment, working conditions, earnings and social guarantees. The results of the study allow us to better understand the essence of employment as a social, economic, demographic and legal category.
1. konferenca Celovito zagotavljanje varnosti v organizacijah: Varnost in zdravstvene institucije, zbornik povzetkov
Authors: Dvojmoč Miha , Lobnikar Branko
Published: August 2024

Izhodišče konference je poudariti pomen celovitega zagotavljanja varnosti v zdravstvenih institucijah. Osrednji temi konference sta varnost v zdravstvenih institucijah, tudi z vidika aktivnosti korporativne varnosti, ter pomen koncepta »eno zdravje« za zagotavljanje kakovosti javnega zdravstva. Zagotavljanje varnosti zaposlenih v zdravstvenih institucijah je predpogoj za varno in kakovostno obravnavo pacientov. Pomembno vlogo pri tem ima korporativna varnost, prilagojena organizaciji in področju, ki poleg varnosti za zaposlene in stranke temelji tudi na kakovostnem obvladovanju varnostnih tveganj in groženj v zdravstvenih institucijah. Koncept enega zdravja pomembno dopolnjuje pristope zagotavljanja varnosti v zdravstvenih institucijah. Eno zdravje je inkluzivni in večsektorski pristop, ki deluje na lokalni, regionalni, nacionalni in globalni ravni s ciljem doseganja optimalnih zdravstvenih rezultatov. Poudarja medsebojno povezanost med ljudmi, živalmi, rastlinami in njihovim skupnim okoljem.
Radical socialization? Analysis of the secondary socialization process in the table tennis environment
Authors: Witkowska Julia , Kossakowski Radosław
Published: August 2024

The article is devoted to the analysis of the secondary socialization process in the table tennis environment. Sports communities represent a specific case study in this context because the secondary socialization processes occurring in them seem more radical. The sports environment is characterized by highly specific features and values conveyed, and interest in this phenomenon may be heightened because sports are a relatively less studied area in terms of their socialization impact on individuals. The main goal of the text is to analyse the specificity of the table tennis environment as a secondary socialization environment. More specific goals include issues related to the specific bonds and relationships formed in such an environment, the specific communication system (slang and characteristic meanings), and the impact of the sports environment on the relations of table tennis players with the world outside of sports. The qualitative analysis allowed for discovering unique patterns that characterize the socialization process in the sports environment. Among these patterns is the blurring of boundaries between values acquired in the sports environment and the external world, as the respondents transferred sports principles to everyday life practices. The totality of socialization in the sports environment also influences the formation of a specific “socialization bubble” and problems in establishing relationships with people not belonging to the sports world: the sports environment became, for many respondents, a reality in itself, generating bonds, rules, and communication patterns for its participants.
Machuqolqa: de una aldea doméstica temporal a un centro de almacenaje inca
Authors: Delgado González Carlos , Guardapuclla Aragón Jaime , Socualaya Dávila Carlos
Published: August 2024

En la historia mundial, los estados suelen utilizar la propaganda para reivindicar un control territorial continuo. Sin embargo, dicho control siempre ha sido discontinuo, es decir, más intensivo en algunas partes que en otras. En los Andes prehispánicos, las crónicas coloniales españolas repitieron la propaganda inca y afirmaron el ejercicio de un control territorial continuo en el corazón de su imperio. Este artículo se ocupa de Machuqolqa, una aldea dispersa con una ocupación agropastoril intermitente y semimóvil entre los años 1300 y 1400 d.C., pero que a partir del siglo XV y durante toda la ocupación inca incorporó recintos residenciales y depósitos de almacenaje de alimentos —materiales empleados para obtener recursos y seguir una política de redistribución con los grupos étnicos locales—. Esta investigación demostrará cómo los grupos preexistentes en Machuqolqa y Raqchi, un asentamiento cercano, mantuvieron cierta autonomía en el desarrollo de sus actividades económicas y sociales aún bajo el dominio incaico.
PENDIDIKAN AKHLAK DALAM ALQURAN MENURUT TAFSIR AL-MISHBAH DAN RELEVANSINYA DENGAN PENDIDIKAN ISLAM MASA MODERN (SURAH ALI IMRAN AYAT 159, SURAH AL-AN’AM AYAT 151, SURAH AL-ISRA AYAT 23-24)
Authors: Ilmillah Fadlilatul
Published: August 2024

Nowadays, juvenile delinquency is very worrying. One of the factors is moran degeneration. This incident is contrary to the purpose of Islamic Education in schools, namely to increase faith and piety as well as fostering gloriuous morals. The purposes of this research are: (1) To describe the interpretation of al-Mishbah on moral education verses in Quran (2) To describe relevance moral education in Quran with modern Islamic education. This research used qualitative approach with library research type. As for the technique used in this research is documentation technique, namely data collection in the form of Quran verses related to the research object. These research results showed that: (1) The interpretation of al-Mishbah regarding the moral education contained in the Quran is birrul walidain education, be gentle with everyone, and easy to forgive (2) The relevance of moral education in Quran with the modern Islamic education is to teach birrul walidain education, and teacher becomes the role model to show gentleness, and forgiveness
 
Abstrak
Pada zaman sekarang, kenakalan remaja sangat memprihatinkan. Salah satu penyebabnya adalah kemerosotan moral. Peristiwa tersebut bertolak belakang dengan tujuan pendidikan Islam di sekolah yaitu untuk meningkatkan keimanan dan ketaqwaan serta pembinaan akhlak mulia dan budi pekerti luhur. Oleh karena itu, tujuan dari penelitian ini (1) Mendeskripsikan tafsir al-Mishbah tentang ayat-ayat pendidikan akhlak dalam Alquran (2) Mendeskripsikan relevansi pendidikan akhlak dalam Alquran dengan pendidikan Islam masa modern. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian library research (kepustakaan). Adapun teknik yang digunakan dalam penelitian ini adalah teknik dokumentasi, yaitu pengumpulan data berupa ayat-ayat Alquran yang berkaitan dengan objek penelitian. Hasil penelitian ini menunjukkan bahwa: (1) Tafsir al-Mishbah tentang pendidikan akhlak yang terkandung dalam Alquran adalah pendidikan birrul walidain, bersikap lemah lembut kepada semua orang, mudah memaafkan, dan bermusyawarah (2) Relevansi pendidikan akhlak dalam Alquran dengan pendidikan Islam masa kini adalah mengajarkan pendidikan birrul walidain, serta pendidik menjadi teladan untuk menunjukkan sikap lemah lembut, dan mudah memaafkan.
IMPLEMENTASI MODEL PEMBELAJARAN DISCOVERY LEARNING UNTUK MENINGKATKAN MINAT BELAJAR PESERTA DIDIK PADA MATERI IMAN KEPADA RASUL KELAS XI DI SMKM 7 GONDANGLEGI
Authors: Ansori Isa , Muslimin Imam , Amrullah Abdul Malik Karim
Published: August 2024

This classroom action research aims to improve student learning outcomes by improving the learning process in Islamic Religious Education subjects, through the Discovery Learning model and finding out how much interest they have. This classroom action research was conducted at SMKM 7 Gondanglegi with the research subjects being class XI students with a total of 29 students. This research is a type of classroom action research. The research was carried out in 3 cycles. The steps of this research begin with a pretest with the next stage being a posttest, to determine the understanding and learning success that students have achieved. From the research results it can be concluded that the application of Discovery Learning in PAI subjects can improve the learning outcomes of class XI students at SMKM 7 Gondanglegi. This increase can be seen from the average post test score for cycle I, namely 75.3 with a completion score reaching 65.5%. In cycle II there was an increase with the average post test score being 78.04 with a completeness score reaching 79.3%. Meanwhile, in cycle III, the change in scores was very significant, the average post test score was 83.8 with a completeness score reaching 93.1%. Thus, the application of the Discovery Learning model is considered successful in improving student learning outcomes in PAI material because it has achieved the predetermined success indicator, namely 75%.
MENINGKATKAN KEMAMPUAN MENGHAFAL HURUF HIJAIYAH DENGAN MENGGUNAKAN METODE MULTIMEDIA/GADGET KELOMPOK B2 DI TK TANWIRUL HUDA PADANGSARI MAJENANG
Authors: Nur Neli Alfi , Yaqien Nurul , Rossidy Imron
Published: August 2024

This research is based on the problem of (a) How is the application of multimedia/gadget methods in improving the ability to memorize Hijaiyah letters in Tanwirul Huda Kindergarten Padangsari Majenang? (b) What is the impact of using multimedia/gadget methods on children's motivation and interest in memorizing the Hijaiyah Letters at Tanwirul Huda Kindergarten Padangsari Majenang? Meanwhile, the aim of this research is (a) Improving the ability to memorize the Hijaiyah letters of children at Tanwirul Huda Kindergarten Padangsari Majenang through the use of multimedia/gadget methods. (b) Knowing the impact of using multimedia/gadget methods on children's motivation and interest in memorizing Hijaiyah Letters at Tanwirul Huda Kindergarten Padangsari Majenang. This research uses three rounds of action research. Each round consists of four stages, namely: Planning, Action, observation and reflection. The target of this research is grade 1 students for the 2023-2024 academic year. The data obtained is in the form of formative test results, observation sheets of teaching and learning activities. From the results of the analysis, it was found that student learning achievement increased from cycle I to cycle II, namely, pre-cycle (35%), cycle I (65%), cycle III (75%). The conclusion of this research is that the increase in the ability to memorize Hijaiyah letters using the Multimedia/Gadget Method for Group B2 at Tanwirul Huda Kindergarten Padangsari Majenang is very significant
Abstrak
Penelitian ini berdasarkan permasalahan (a) Bagaimana penerapan metode multimedia/gadget dalam meningkatkan kemampuan menghafal huruf Hijaiyah di TK Tanwirul Huda Padangsari Majenang? (b) Apa dampak penggunaan metode multimedia/gadget terhadap motivasi dan minat anak-anak dalam menghafal Huruf Hijaiyah di TK Tanwirul Huda Padangsari Majenang? Sedangkan tujuan dari penelitian ini adalah (a) Meningkatkan kemampuan menghafal Huruf Hijaiyah anak-anak di TK Tanwirul Huda Padangsari Majenang melalui penggunaan metode multimedia/gadget. (b) Mengetahui dampak penggunaan metode multimedia/gadget terhadap motivasi dan minat anak-anak dalam menghafal Huruf Hijaiyah di TK Tanwirul Huda Padangsari Majenang. Penelitian ini menggunakan penelitian tindakan (action research) sebanyak tiga putaran. Setiap putaran terdiri dari empat tahap yaitu : Perencanaan, Tindakan, observasi dan refleksi. Sasaran penelitian ini adalah siswa kelas 1 Tahun pelajaran 2023-2024.  Data  yang diperoleh berupa hasil tes formatif, lembar observasi kegiatan belajar mengajar. Dari hasil analis didapatkan bahwa prestasi belajar siswa mengalami peningkatan dari siklus I sampai siklus II yaitu, pra siklus (35%), siklus I (65%), siklus III (75%). Simpulan dari penelitian ini peningkatkan Kemampuan Menghafal Huruf Hijaiyah Dengan Menggunakan Metode Multimedia/Gadget Kelompok B2 Di TK Tanwirul Huda Padangsari Majenang sangat signifikan