bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Characterization of a Long Term Survivor Double Metastatic Non Small Sell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gefitinib in Combination with Gemcitabine Plus Nab-Paclitaxel and mFOLFOX6 as First and Second Line Therapy
Authors: Brunetti Oronzo , Badalamenti Giuseppe , De Summa Simona , Calabrese Angela , Argentiero Antonella , Fucci Livia , Longo Vito , Perrotti Pia , Pinto Rosamaria , Petriella Daniela , Danza Katia , Tommasi Stefania , Leonetti Francesco , Silvestris Nicola
Published: May 2019

Management of multiple primary cancers, a not so infrequent event in oncology practice, is a critical issue due to the lack of literature . In this study, we reported the case of a patient with metachronous double metastatic non small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) who received gefitinib in combination with gemcitabine plus nab-paclitaxel and with mFOLFOX6 in first and second line, respectively. She achieved a progression free survival and an overall survival (OS) of 28 months for NSCLC and PFS-1 and OS of 20 and 13 months, respectively for PDAC. Moreover, the combination of gefitinib and chemotherapies treatments displayed a good safety profile. Given the insignificant frequency of this case, we performed a molecular characterization of both neoplasms with the aim to investigate the existence of particular activated pathways and/or similar immunological mutations. it is interesting to note that two neoplasms shared a commune mutation of B7-H3 gene, with the consecutive impairment of its expressed protein. In both PDAC and NSCLC, the expression of this protein was associated with a worse survival. Since B7-H3 is an anti-apoptotic protein, the reduction of its expression or function should justify a pro-apoptotic activity with a putative justification of the long survival of the patient considered in this report.
Anomeric Spironucleosides of β-D-Glucopyranosyl Uracil as Potential Inhibitors of Glycogen Phosphorylase
Authors: Stathi Aggeliki , Mamais Michael , Chrysina Evangelia D. , Gimisis Thanasis
Published: May 2019

Glycogen phosphorylase (GP) has been a target for compounds, inhibitors of GP that might prevent unwanted glycogenolysis under high glucose conditions and thus aim at the reduction of excessive glucose production from the liver, in the case of type 2 diabetes. Anomeric spironucleosides, such as hydantocidin, present a rich synthetic chemistry and possess important biological function. We have successfully applied the Suárez radical methodology to synthesize the first example of a 1,6-dioxa-4-azaspiro[4.5]decane system, not been previously constructed via a radical pathway, starting from 6-hydroxymethyl-β-D-glucopyranosyluracil. We have shown that in the rigid pyranosyl conformation the required [1,5]-radical translocation is a minor process. The stereochemistry of the spirocycles obtained were unequivocally determined based on the chemical shifts of key sugar protons in the 1H NMR spectra. The two spirocycles were found to be modest inhibitors of RMGPb.
Effect of Flipped Classroom Model on Indonesian EFL Students’ Writing Achievement across Cognitive Styles
Authors: Mubarok Ahsin Fahmi , Cahyono Bambang Yudi , Astuti Utari Praba
Published: May 2019

Recently, there have been a lot of studies examining the effect of the application of flipped classroom model. However, most of the studies focused on students’ achievement without much regard on cognitive styles. This study was aimed to investigate the effect of flipped classroom model on Indonesian EFL students’ writing achievement across cognitive styles (i.e., field dependent and field independent). It involved 58 university students from two intact classes which were divided into experimental and control groups. Both groups were given a pre-test and a post-test to know their writing achievement before and after treatment. The results of the study revealed that the mean score of the students from the experimental group was significantly higher than that of the students from the control group (p < 0.016). This study also uncovered the significantly different interaction of students from each cognitive style.
DA’WA, MUSLIM MILLENNIALS AND SOCIAL MEDIA
Authors: Zulhazmi Abraham Zakky , Hastuti Dewi Ayu Sri
Published: May 2019

The link between religion and cyberspace has become a necessity in the cyber era. The internet, in this case social media, changes many patterns and forms of communication. Social media has become a massive channel used by Indonesian preachers for the past decade or so. Da'wah on social media presents a number of challenges and opportunities, especially when dealing with millennials as majority users. This study intends to describe the phenomenon of da'wah on social media among millennial Muslims. This research is a descriptive qualitative research with literature study as a data collection method. The conclusion of this study is that there are three main points in viewing da'wa, millennial Muslims and social media. First, the character of millennial generation who tend to be out of the box and always connected to the internet more or less changes the da'wah landscape in Indonesia. They slowly leave the conventional da'wa, both in terms of theme and method choices. The popularity Hanan Attaki’s da’wah became one of the markers. Secondly, social media despite having a positive contribution to da'wah but also left a number of notes that demand attention, such as prejudice, easy spread of hate speech, reluctance to access primary sources and quality filter problems. Third, looking at millennial generations who have the characteristics of tolerance, pluralism and being able to appreciate diversity brings opportunities for the development of moderate Islamic da'wah in Indonesia. Keywords: da’wah, millenial, social media
Upaya Pencapaian Daya Saing Usaha Sapi Perah Melalui Kebijakan Pemerintah dan Peningkatan Pendapatan Peternak
Authors: Rusdiana Supardi , Soeharsono Soeharsono
Published: May 2019

Menghadapi persaingan usaha ternak sapi perah dapat diupayakan melalui pengembangan industri peterakan yang mengarah pada usaha komersial. Usaha ternak sapi perah induk laktasi, dapat diarahkan pada peningkatan ekonomi dan kesejahteraan peternak. Berdasarkan permasalahan tersebut diatas, terlihat upaya  pencapaian daya saing usaha sapi perah dipeternak masih lemah, sehingga dibutuhkan dukungan modal usaha. Tulisan ini bertujuan membahas mengenai tinjauan konseptual upaya pencapaian daya saing usaha sapi perah melalui kebijakan pemerintah dan peningkatan pendapatan peternak. Upaya Pemerintah untuk menciptakan berbagai produk hasil peternakan dapat bersaing dan mampu memotori industrialisasi perdesaan. Kebijakan Pemerintah dengan meningkatkan tarif impor pada produk susu sapi perah akan berpengaruh positif terhadap daya saing usaha ternak sapi perah di peternak. usaha ternak sapi perah di peternak akan semakin meningkat nilai keuntungan secara kompetitif dan keunggulan komparatif. Produksi susu sapi perah yang dihasikan dapat memenuhi kebutuhan pasar, dan secara tidak langsung perekonmian peternak meningkat. Usaha sapi perah dengan skala 4 ekor induk laktasi, peternak mendapatkan keuntungan bersih sebesar Rp.21.007.000,-/tahun R/C ratio 1,5. Keuntungan pada kelompok peternak sapi perah Maju Terus sebesar Rp.1.718.794,53,-/tahun  nilai R/C ratio 2,18. Ke dua usaha sapi perah di peternak nilai R/C rasio sangat baik dan  >1. Usaha ternak sapi perah di peternak  secara ekonomi layak untuk diusahakan kembali.
APEX-seq: RNA subcellular localization by proximity labeling
Authors: Fazal Furqan M. , Han Shuo , Parker Kevin R. , Kaewsapsak Pornchai , Xu Jin , Boettiger Alistair , Chang Howard Y. , Ting Alice Y.
Published: May 2019

We introduce APEX‑seq, a method for RNA sequencing based on direct proximity labeling of RNA using the peroxidase enzyme APEX2. APEX‑seq in nine distinct subcellular locales produced a nanometer-resolution spatial map of the human transcriptome as a resource, revealing extensive and exquisite patterns of localization for diverse RNA classes and transcript isoforms. APEX‑seq should be widely applicable to many systems, enabling comprehensive investigations of the spatial transcriptome.
Free vibration of a Levy-type solution for plates based on two-variable refined plate theory by using SEM
Authors: Kiryu Shota , Alisjahbana Sofia W. , Alisjahbana Irene , Nagao Mitsuo , Gan Buntara S.
Published: May 2019

The exact solution of structural dynamic related problems can be achieved by using the frequency-dependent spectral method. The exact solution is thought to be accurate while reducing the number of degree-of-freedom to resolve the cost and computational drawbacks. This paper investigates the vibrational characteristics of a Levy-type solution of thick plates considering shear deformation based on the two-variable Refined Plate Theory (RPT). The plates, which are modeled by an isotropic Levy-type rectangular plate, were solved by using the Spectral Element Method (SEM). The SEM for RPT Levy-type in the frequency domain is derived to formulate the free vibration problems of the plates. Transcendental stiffness matrices are well established in vibration, formulated from the exact solutions of the differential equations of the RPT Levy-type plate element. The present spectral element model has four line-type degree-of-freedoms (DOF) on each edge of the Levy-type rectangular plate. Natural frequencies of the plate are computed by means of the Wittrick-Williams algorithm. Numerical comparisons are given to show the effectiveness, efficiency, and accuracy of the SEM by using one element. Unlike the FEM, the SEM gives exact solutions of the natural frequencies of plates without element discretization procedures.
Stochastic P-bifurcation in a tri-stable Van der Pol system with fractional derivative under Gaussian white noise
Authors: Li Yajie , Wu Zhiqiang
Published: May 2019

In this paper, we study the tri-stable stochastic P-bifurcation problem of a generalized Van der Pol system with fractional derivative under Gaussian white noise excitation. Firstly, using the principle for minimal mean square error, we show that the fractional derivative term is equivalent to a linear combination of the damping force and restoring force, so that the original system can be transformed into an equivalent integer order system. Secondly, we obtain the stationary Probability Density Function (PDF) of the system’s amplitude by the stochastic averaging, and using the singularity theory, we find the critical parametric conditions for stochastic P-bifurcation of amplitude of the system, which can make the system switch among the three steady states. Finally, we analyze different types of the stationary PDF curves of the system amplitude qualitatively by choosing parameters corresponding to each region divided by the transition set curves, and the system response can be maintained at the small amplitude near the equilibrium by selecting the appropriate unfolding parameters. We verify the theoretical analysis and calculation of the transition set by showing the consistency of the numerical results obtained by Monte Carlo simulation with the analytical results. The method used in this paper directly guides the design of the fractional order controller to adjust the response of the system.
Anti-overturning stability coefficient of curved girder bridges considering seismic action
Authors: Deng Tongfa , Zhang Junping , Li Shuai , Wang Yi
Published: May 2019

To overcome the limitation of terrain and ground objects, curved girder bridges normally adopt a single column pier, on which a single bearing or double bearings with small spacing are seated, making it weak in anti-overturning ability under eccentric load. Presently, the vehicle centrifugal force and seismic action are rarely considered when calculating the anti-overturning stability and tend to aggravate the deflection of curved girder bridges. In this paper, a calculation method is proposed to determine the anti-overturning stability coefficient under earthquake; the calculating equation of anti-overturning stability coefficient under static action is modified. The results show that the influence of centrifugal force cannot be neglected. Otherwise, the calculation of overturning stability is unsafe. The anti-overturning stability of curved girder bridges under earthquake is lower than that under static action. Further, the effect of different structural parameters on the anti-overturning stability coefficient under static and seismic action is similar: the anti-overturning stability coefficient decreases with the growth of bridge deck width, while first decreases sharply and then increases slowly with the growth of curvature radius.
Experimental study on the hydraulic capacity of grate inlets with supercritical surface flow conditions
Authors: Kemper Svenja , Schlenkhoff Andreas
Published: May 2019

Due to an increasing number of heavy rainfall events, the managing of urban flooding requires new design approaches in urban drainage engineering. With bidirectional coupled numerical models the surface runoff, the underground sewer flow and the interaction processes between both systems can be calculated. Most of the numerical models use a weir equation to calculate the surface to sewer flow with unsurcharged flow conditions, but uncertainties still exist in the representation of the real flow conditions. Street inlets, existing in different types, are the connecting elements between the surface and the underground system. In the present study, an empirical formula was developed based on physical model test runs to estimate the hydraulic capacity and type-specific efficiency of grate inlets with supercritical surface flow. Influencing hydraulic parameters are water depth and flow velocity upstream of the grate and, in addition, different geometrical parameters are taken into account, such as the grate dimensions or the orientation of the bars (transverse, longitudinal or diagonal). Good agreement between estimated and measured results could be proven with relative deviations less than 1%.
Adipic Acid as a Biodegradable Solid Acid Catalyst for One-Pot, Three Component Synthesis of 1-Amidoalkyl-2-naphthols
Authors: Darbandi Hassan , Kiyani Hamzeh
Published: May 2019

Background:

1-Amidoalkyl-2-naphthols are an attractive group of organic compounds
that can be converted to oxazine heterocycles and aminoalkyl naphthols. The derivatives of 1-
amidoalkyl-2-naphthols have significant biological activities and act as drug candidates.

Methods:

1-Amidoalkyl-2-naphthols were synthesized via the three-component condensation reaction
of 2-naphthol, acetamide/benzamide and various aldehydes in the presence of 10 mol% of adipic
acid as an organocatalyst under solvent-free conditions at 120°C.

Results:

A simple, efficient, and operative method for the synthesis of 1-amidoalkyl-2-naphtholes in
the presence of adipic acid as the biodegradable catalyst is introduced. Easy operation, acceptable reaction
times, eco-friendly, availability of starting materials, simple separation of products, and high
yields of products are the significant results of this method.

Conclusion:

In this study, 1-amidoalkyl-2-naphthols were synthesized using commercially available
reactants in excellent yields and relatively shorter times. In this process, microwave or ultrasonic
waves were not used to provide energy for the reaction.
High Catalytic Activity of Pd Nanoparticles Synthesized from Green Alga Chlorella vulgaris in Buchwald-hartwig Synthesis of N-Aryl Piperazines
Authors: Mishra Vaibhav , Arya Anju , Chundawat Tejpal Singh
Published: May 2019

Background:

The N-aryl piperazines are an important component of many drug products
used for the treatment of malaria, depression, anxiety and Parkinson diseases. Buchwald-Hartwig
amination is the latest and well-known reaction for Pd catalyzed direct synthesis of N-aryl piperazine
from aryl halides. Although several Pd-ligand systems have already been discovered for this conversion,
Pd nanoparticles are recently being used for this useful coupling reaction due to their recyclability
and durability. Metal nanoparticles show enhanced catalytic activity compared to their bulk counterparts
due to increased surface area at the edges and corners. The use of green algal extract in place
of chemical ligands makes this process more environment-friendly and cost-effective. In this research,
Pd nanoparticles synthesized using green alga C. Vulgaris were utilized as an alternative approach
for the coupling reaction during the preparation of N-aryl piperazines.

Methods:

Synthesized Pd nanoparticles from C. Vulgaris were characterized by FTIR, SEM and
XRD techniques. The catalytic activity of the synthesized nanoparticles was monitored for the synthesis
of N-aryl piperazines by Buchwald-Hartwig reaction. The synthesized N-aryl piperazines were
characterized by NMR, FTIR and mass analysis.

Results:

A very good catalytic activity of the synthesized Pd nanoparticles from green alga Chlorella
vulgaris extract was observed. The green alga not only reduces the size of the Pd metal to nanoparticles
but also acts as a green ligand for reduction of Pd(II) to Pd(0) during nanoparticle synthesis. Using
this Pd nanoparticles-green ligand system, several N-aryl piperazines were synthesized in good to
excellent yields. Reaction conditions for better conversion were optimized. The comparative advantage
of the catalytic system with recently published works on Buchwald-Hartwig C-N coupling
reaction is given. Recyclability and durability of the catalyst were explored and the results were
found to be promising. A plausible mechanism of Pd nanoparticle catalyzed reaction is also proposed.

Conclusion:

Catalytic activity of the Pd nanoparticle synthesized from Chlorella vulagris in the synthesis
of N-aryl piperazines by Buchwald-Hartwig reaction is reported first time to the best of our
knowledge and understanding. The green approach of Pd catalyst to facilitate the reaction and its environmental
impact is the main characteristic of the process.
Avaliação de programas de pós-graduação: um projeto incompleto
Authors: Silva Juremir Machado da
Published: May 2019

Este artigo discute os critérios de avaliação dos programas de pós-graduação no Brasil, desconstruindo algumas das suas principais caraterísticas, contradições e ambiguidades. Com base no conceito de campo apresentado por Bourdieu (1997), o autor esclarece a rede de interesses que se estabelecem no campo científico e académico. Nela, além dos próprios investigadores, acabam por estar implicadas as instituições, em particular as de financiamento e apoio à investigação, no quadro das pós-graduações. No final no texto são apresentadas algumas sugestões de melhoria em relação ao sistema atual.
Desenvolvendo uma teoria repertório - colaboração, raça e género tal como aplicada à política em CTEM
Authors: Parker Marla A. , Bozeman Barry
Published: May 2019

Este artigo apresenta a teoria “repertório colaboração, raça e género” (adiante designada como RCRG) problematizando como a tomada de consciência sobre a importância da raça e do género influencia os comportamentos de colaboração e a escolha dos membros das equipas em ciência, tecnologia, engenharia e matemática (CTEM). Estamos particularmente interessados na aplicação do RCRG no contexto do ensino superior em CTEM, espaço tradicionalmente entendido como lugar privilegiado para iniciativas relacionadas com a diversidade. Utilizando omodelo de capital científico, técnico e humano (CCTH) como ponto de partida, elaborámosa teoria do RCRG, tendo em conta três variáveis essenciais: as normas de colaboração entrecientistas; a dinâmica de intercâmbio social e o desenvolvimento e utilização de sensibilizaçãorelativa a raça e a género. Apesar da existência de muitas teorias que explicam o papel da raça edo género na obtenção de resultados educacionais, profissionais e sociais, poucas têm em contaos aspetos únicos da cultura e das instituições de CTEM, particularmente no que respeita aosmodos de produzir ciência com base na colaboração e no trabalho em equipa - dois elementoscruciais para a produção de conhecimento em CTEM. Afirmamos que uma teoria específica quetenha em consideração o contexto das CTEM pode desencadear mais esforços estratégicos paraalcançar uma diversidade mais significativa, promover a produtividade em CTEM e potenciar ovalor público da ciência.
Será a investigação sobre alterações climáticas verdadeiramente colaborativa?
Authors: Bento Sofia , Varanda Marta , Richard-Ferroudji Audrey , Faysse Nicolas
Published: May 2019

O artigo centra-se no estudo da interação e da troca de conhecimento entre cientistas e stakeholders na investigação para adaptação às alterações climáticas. Baseia-se numa investigação realizada no contexto de um programa Europeu denominado Circle Era-Net delineado para impulsionar a ligação entre cientistas e stakeholders, através de uma rede de pesquisa europeia que estuda as alterações climáticas. Foram entrevistados 33 cientistas, stakeholders e financiadores envolvidos em sete projetos apoiados pelo programa Circle-Med. A colaboração e a troca de conhecimentos constituíram intenções reconhecidas, mas não foram práticas observáveis nas atividades promovidas pelas várias equipas de investigação. A partir destes resultados, defende-se serem necessárias melhorias que permitam alcançar uma ciência verdadeiramente colaborativa entre cientistas e stakeholders. Neste sentido, o artigo apresenta algumas sugestões relativas à conceção de novos critérios para as chamadas de projetos de investigação, assim como à monitorização e à avaliação do processo colaborativo numa pesquisa científica e à integração das Ciências Naturais e sociais na investigação sobre alterações climáticas.
Crianças e infâncias na Cultura Visual: concepções e narrativas fotoetnográficas
Authors: Coelho Fernanda Mendes Cabral , Dias Adelaide Alves
Published: May 2019

Este artigo tem o objetivo de ressaltar a importância da Cultura Visual para a compreensão histórica e social das concepções de crianças e infâncias constituídas à luz dos pressupostos teóricos da Sociologia da Infância, bem como destacar o uso da narrativa fotoetnográfica para a compreensão da realidade em pesquisas científicas, mais especificamente relacionadas à Infância. Para tanto, apresenta três narrativas imagéticas produzidas a partir das imagens de crianças dispostas em pesquisas científicas no Brasil, pautadas nos pressupostos epistemológicos e empíricos da História e da Sociologia da Infância. Trata-se de um estudo qualitativo e descritivo, de estratégia fotoetnográfica, com uma análise produzida à luz de uma perspectiva crítica e transdisciplinar multireferencial. Através das narrativas fotoetnográficas, o estudo revelou que as infâncias se constituem na multiplicidade das sociedades humanas, em que cada época e contexto oferecem às crianças possibilidades de criação e apropriação cultural, desencadeando assim, novas e inusitadas formas de vida, onde as crianças criam para si estratégias de sobrevivência e resistência. Neste sentido, pensar o universo das culturas infantis na perspectiva da Cultura Visual requer um movimento constante de reflexão sobre como estes espaços refletem concepções e imagens de crianças e contribuem para a formação dessas culturas.
Nota introdutória – Estudos Culturais, Cidadania e Democracia
Authors: Martins Moisés de Lemos , Sidoncha Urbano , Bandeira Messias
Published: May 2019

Os modelos de pertença social mudaram radicalmente nas últimas décadas, pelo impacto que a mobilização tecnológica da época tem na vida dos indivíduos e das sociedades...
Dilemas da cultura e democracia no Brasil contemporâneo
Authors: Rubim Antonio Albino Canelas
Published: May 2019

O agendamento da cultura e democracia caracterizam o mundo e o Brasil contemporâneo. A democracia domina o cenário atual por meio de um complexo conjunto de variantes, que se debatem entre complementariedades possíveis e contradições flagrantes. Na atual circunstância mundial, a democracia tem se afirmado enquanto valor (quase) universal, ainda que em versões e visões muitas vezes visivelmente contrastantes e conflitantes. Daí as ferozes disputas que acontecem em seu nome, envolvendo sua definição e sua delimitação. Na contemporaneidade, inúmeros conflitos perpassam sua onipresença e onipotência. Em resumo, sua hegemonia como valor reivindicado por (quase) todos, funciona fundada em um conceito-ônibus, no qual tudo parece caber. Todos conclamam e proclamam a democracia, mas, como anotado, estas manifestações vêm acompanhadas por intensas lutas por sua definição e delimitação. Assim, a democracia e seus conflitos adquirem uma centralidade na cena atual internacional e nacional. Com a cultura acontece algo similar, só que em intensidade bem mais branda, pois ela surge como um campo de disputa mais leve.
Entre o Estado e a sociedade – circulação de profissões da elite da política
Authors: Silva Esser , Martins Moisés de Lemos
Published: May 2019

Este artigo pretende, por um lado, explorar as ordenações teóricas que traçam a formação da classe eleita – ou as elites – transcorrendo a sua afirmação da circulação das profissões que acedem ao campo político e, por outro, entrecruzando os estudos de Foucault sobre parresía e elutéria com a noção weberiana de fechamento partidário, compreender o modo como os profissionais da política articulam a sua existência entre a vida civil e a vida estatal. Assim, esta análise orienta-se para a compreensão dos traços distintos dos grupos profissionais, enquanto característica objetiva para acesso e uso do poder em benefício próprio. Assente num estudo, que tem por base o caso dos deputados da Assembleia da República Portuguesa e na constatação que nela predominam “economistas”, “advogados” e “professores”, enquanto membros ativos, escrutam-se duas ordenações em coabitação nesta classe eleita: por um lado, entre o desapego, a ausência de medo e a capacidade de agir francamente, enunciados como qualidades interiores constituintes do político, e por outro lado, as práticas exteriorizadas com fins acobertados nas estratégias dos aparelhos partidários, formam-se duas configurações de sentido – a do político inteiro e a do político fracionado, ambos cultivados numa coexistência hegemónica, que enuncia, como modo extensivo da política, a transmutação da solidariedade ideológica para a introdução do antagonismo económico.
Discursos e imagens do turismo cultural
Authors: Pinto-Coelho Zara , Pinto Roque
Published: May 2019

O turismo cultural (Richards, 2007; Smith, 2003) é reconhecido como uma área em crescimento da indústria cultural global...
Navegando estilos: uma recensão crítica sobre o Instagram e a imagem contemporânea por Lev Manovich
Authors: Zamora Daniel López
Published: May 2019

O autor Lev Manovich é um académico russo e um pensador da cultura digital bem conhecido nas artes e nas culturas digitais desde a publicação de seu livro The language of new media (2001)...
ESTUDOS CULTURAIS E FORMAÇÃO PROFISSIONAL EM LAZER: Das Identidades e Concepções de Sujeitos
Authors: Santos Samuel
Published: May 2019

Atualmente, o campo do lazer necessita de novos estudos sobre as concepções de sujeito, sobretudo pela multiplicidade de projetos e propostas de formação nesse setor. O estudo em questão discute identidades culturais e concepções de sujeito, ambas embasadas em Stuart Hall. Com isso, procuro apontamentos dos Estudos Culturais para a formação profissional em lazer. Na metodologia da pesquisa são articulados os referenciais bibliográficos de cultura, currículo e lazer. Assim, pesquisas de currículos para formação profissional em lazer, identidades culturais e atuações em distintos contextos com múltiplos sujeitos são novos mapas de estudo para a área. Logo, precisamos pensar a mobilização de saberes e as transformações nas experiências cotidianas das políticas educacionais, esportivas e culturais com lazer.
‘Um ódio tão intenso…’. Temos de falar sobre o Kevin. Pós-feminismo e cinema feminino
Authors: Thornham Sue
Published: May 2019

Este artigo explora o filme de 2011 de Lynne Ramsay, Temos de Falar Sobre o Kevin, no contexto daquilo que foi designado “novo mamaísmo” e à luz dos principais debates feministas sobre representação materna, genealogia matriarcal, produção cultural feminista e melodrama clássico e contemporâneo. O “novo mamaísmo”, argumentaram os críticos, constitui um regresso pós-feminista à imagem idealizada da feminilidade doméstica que dominou a América dos anos 50 do século XX. A diferença é que a maternidade intensiva é, agora, vista como uma escolha iluminada da mulher livre, um argumento que permite mascarar a centralidade continuada de um dualismo de género que determina, quer as nossas estruturas institucionais, quer as nossas fantasias públicas. Defendendo que o filme de Ramsay deve ser visto como sendo parte de uma tradição feminista de realização cinematográfica que sujeita a uma reapreciação crítica, quer estas fantasias públicas, quer a forma do melodrama materno em cuja corporalidade se encontram normalmente inscritas, o artigo analisa pormenorizadamente a exploração, pelo filme, das questões de identidade feminina, agência e controlo. Ao contrário do que acontece com os seus antecessores, defende-se, Ramsay convida-nos a habitar a subjetividade fraturada, o ódio e o sentimento de culpa da mãe nesta exploração. Embora não exista, como afirmou Ramsay, uma “redenção” fácil no final do filme, o seu fim leva-nos para além das fantasias gémeas do masoquismo materno pós-feminista e da agência feminista não problemática, no sentido de uma possibilidade de subjetividade que poderá aceitar, mais do que negar, o incontrolável desarranjo da corporalidade materna.
As mulheres na mobilidade acadêmica internacional: uma caracterização das pesquisadoras brasileiras na Universidade do Minho
Authors: Cerqueira Sônia , Ribeiro Rita
Published: May 2019

A ciência tem avançado no debate sobre as relações de gênero, todavia ainda repousa sobre desníveis entre homens e mulheres, o que os conduz a escolhas e motivações distintas no âmbito da sua carreira acadêmica e científica. Com as exigências da internacionalização da educação, novos desafios se impõem para as mulheres, sobretudo, em relação à sua inserção no contexto das estratégias políticas adotadas para atender à dinâmica global da educação. Dentre estas estratégias, encontra-se a mobilidade acadêmica internacional, cujo objetivo é estimular o envio de estudantes e pesquisadores para centros de pesquisa no estrangeiro. O sistema brasileiro de Ciência e Tecnologia vem alargando investimentos neste setor, com a distribuição de bolsas de pesquisa para os diversos graus. Mas qual a representação feminina neste cenário e quais os significados que atribuem a esta prática da mobilidade? A partir de um inquérito realizado com 52 mulheres brasileiras em mobilidade acadêmica na Universidade do Minho, inscritas em cursos de pós-graduação, este estudo objetivou traçar um perfil destas estudantes e pesquisadoras, abordando as suas características pessoais, sociais, culturais e acadêmicas, além das principais motivações subjetivas que definem a escolha por este tipo de mobilidade.
Género e corporificação na sociedade mundial
Authors: Connell Raewyn
Published: May 2019

O feminismo contestou as ideologias de género conservadoras, realçando a construção social do género, o que suscitou o risco de tratar o género como sendo descorporificado. O género é, efetivamente, integralmente social, mas também é corporificado, dizendo respeito à forma como os corpos reprodutores entram na história da humanidade. A condução do processo de corporificação social é inerentemente política e afetada por mudanças recentes no mundo institucional. Em particular, as relações de género são reformuladas no colonialismo e na globalização pós-colonial, eles próprios processos genderizados. Na reconfiguração do poder, tem vindo a emergir um novo tipo de classe dominante, organizada à escala mundial, e a sua liderança masculinizada é articulada com patriarcados locais na nova economia. O desenfreado poder neoliberal conduz a novos níveis de mercantilização dos corpos e a novos padrões de violência de género. A resistência e a oposição também necessitarão de novas configurações políticas.
Homonacionalismo como mosaico: viagens virais, sexualidades afetivas
Authors: Puar Jasbir K.
Published: May 2019

Neste artigo irei contextualizar o aumento do número de movimentos de gays e lésbicas no âmbito dos debates sobre os discursos dos direitos e da temática dos direitos, que é seguramente o mais forte afrodisíaco do liberalismo. Analiso o modo como a sexualidade se tornou parte de uma formação essencial na articulação de cidadãos plenos através dos vários registos, como género, classe e etnia, quer nacional, quer transnacionalmente. Este estudo posiciona claramente o homonacionalismo como categoria analítica necessária à compreensão e conceção histórica dos motivos pelos quais o estado de uma nação como simpatizante gay se tornou desejável à partida. Como a Modernidade, o homonacionalismo pode ser objeto de resistência e de resignificação, mas não pode ser excluído: todos somos condicionados por ele e através dele. O artigo encontra-se estruturado em três secções. Começo por apresentar uma panorâmica do projeto Terrorist Assemblages, prestando atenção, em particular, à utilização do termo “homonacionalismo”. Em segundo lugar, discuto o homonacionalismo no contexto da Palestina/Israel, com o objetivo de demonstrar a relevância dos discursos sobre direitos sexuais e da narrativa de “lavagem cor-de-rosa” para a ocupação. Termino com uma reflexão acerca do potencial inerente ao pensamento da sexualidade, não como uma identidade, mas como mosaicos de sensações, afetos e forças. Esta viralidade da sexualidade destabiliza produtivamente as noções humanistas dos sujeitos da sexualidade, assim como a organização política que procura resistir aos discursos jurídicos instituídos com o objetivo de nomear e controlar estes sujeitos de sexualidade.
Estado actual de la Colección Coleopterológica de la Facultad de Estudios Superiores Zaragoza (CCFES-Z), UNAM
Authors: Ordóñez-Reséndiz María Magdalena , Rodríguez-Mirón Geovanni Miguel , López-Pérez Sara
Published: May 2019

Se presenta el estado actual de la Colección Coleopterológica de la Facultad de Estudios Superiores Zaragoza (CCFES-Z), UNAM. La CCFES-Z está integrada por 28,189 ejemplares agrupados en 2,596 morfoespecies pertenecientes a los subórdenes Adephaga, Archostemata, Myxophaga y Polyphaga. El total de individuos corresponden a 10 superfamilias, 60 familias, 85 subfamilias, 238 tribus y 78 subtribus. Hasta el momento se han identificado 808 géneros y 1,207 especies. Entre los géneros mejor representados se encuentran Pachybrachis Chevrolat con 57 morfoespecies (Chrysomelidae), Phyllophaga Harris con 41 (Scarabaeidae), Agrilus Curtis con 39 (Brupestidae), Cryptocephalus Geoffroy con 33 (Chrysomelidae) y Systena Chevrolat con 30 (Chrysomelidae). Se cuenta con 60 ejemplares tipo de las especies Brachiacantha angulata Nestor-Arriola & Toledo-Hernández, B. brevicuspidata Nestor-Arriola & Toledo-Hernández, B. truncata Nestor-Arriola & Toledo-Hernández, Cephalocyclus ordonezi Dellacasa, Dellacasa & Gordon, Macrocopturus burserophagus Muñiz & Ordóñez, Mastostethus gracilis Rodríguez-Mirón y Phyllophaga villardoi Morón & Ordóñez-Reséndiz. Polyphaga es el suborden con mayor número de morfoespecies (2,372) y ejemplares (26,375); sin embargo, Adephaga con sólo tres familias tiene una alta representatividad, 8.5% y 6.4% del total de morfoespecies y ejemplares. Archostemata y Myxophaga están representados por un individuo y una especie, cada uno. Chrysomelidae es la familia más diversa con 859 morfoespecies y 11,295 ejemplares, seguida de Curculionidae y Cerambycidae. Los coleópteros que forman parte de la CCFES-Z documentan especies de 20 entidades federativas de México.
The Impact of Monetary Incentives on Physician Prosocial Behavior in Online Medical Consulting Platforms: Evidence From China (Preprint)
Authors: Jing Dong , Jin Yu , Liu Jianwei
Published: May 2019

BACKGROUND

In online medical consulting platforms, physicians can get both economic and social returns by offering online medical services, such as answering questions or sharing health care knowledge with patients. Physicians’ online prosocial behavior could bring many benefits to the health care industry. Monetary incentives could encourage physicians to engage more in online medical communities. However, little research has studied the impact of monetary incentives on physician prosocial behavior and the heterogeneity of this effect.

OBJECTIVE

This study aims to explore the effects of monetary incentives on physician prosocial behavior and investigate the moderation effects of self-recognition and recognition from others of physician competence.

METHODS

This study was a fixed-effect specification-regression model based on a difference-in-differences design with robust standard errors clustered at the physician level using monthly panel data. It included 26,543 physicians in 3851 hospitals over 133 months (November 2006-December 2017) from a leading online health care platform in China. We used the pricing strategy of physicians and satisfaction levels to measure their own and patients’ degree of recognition, respectively. Physicians’ prosocial behavior was measured by free services offered.

RESULTS

The introduction of monetary incentives had a positive effect on physician prosocial behavior (β=1.057, P<.01). Higher self-recognition and others’ recognition level of physician competence increased this promotion effect (γ=0.275, P<.01 and γ=0.325, P<.01).

CONCLUSIONS

This study explored the positive effect of the introduction of monetary incentives on physician prosocial behavior. We found this effect was enhanced for physicians with a high level of self-recognition and others’ recognition of their competence. We provide evidence of the effect of monetary incentives on physicians’ prosocial behaviors in the telemedicine markets and insight for relevant stakeholders into how to design an effective incentive mechanism to improve physicians’ prosocial engagements.
DEVELOPMENT AND VALIDATION OF A GRADIENT HPLC METHOD FOR QUANTIFICATION OF EDETATE DISODIUM IN LYOPHILIZED INJECTABLE DRUG PRODUCT
Authors: DESHPANDE SHRIPAD , FAROOQUI MAZAHAR , GANAP GAJANAN , KHADKE VISHAL , KAYANDE D. D.
Published: May 2019

Objective: The present study was aimed to validate a developed reversed phase gradient high-performance liquid chromatography method for the quantitative determination of Edetate Disodium in the lyophilized injectable drug product.

Methods: The amount of total Edetate disodium was analysed by HPLC assay using Edetate disodium USP as a reference standard. Injectable product was dissolved in acetone and Edetate disodium is separated out from API and then dissolved in water. Analysis was carried out using ferric chloride as a precolumn derivatizing reagent and YMC Pack ODS-A, 5 µm column with mobile phase as a mixture of tetrabutylammonium bromide buffer pH 2.8 and acetonitrile as the solvent, water used as diluent. The Edetate disodium quantified by U. V. wavelength at 254 nm.

Results: The method was suitably validated with respect to specificity, linearity, precision, accuracy and solution stability, using this method the average recovery from spike sample is 98.2%, with a relative standard deviation of<3%. The minimal quantifiable level was 1.5 µg/ml. The results show that the procedure is accurate, precise and reproducible.

Conclusion: In the present study an attempt has been made to develop and validate the analytical method for lyophilised injectable formulations and to generate the scientific database for formulation and evaluation of various lyophilised injectable containing Edetate disodium.
MICROSPONGES AS A NEOTERIC CORNUCOPIA FOR DRUG DELIVERY SYSTEMS
Authors: RAJESWARI SARIPILLI , SWAPNA VANAPALLI
Published: May 2019

Microsponges (MSPs) are at the forefront of the rapidly developing field of novel drug delivery systems which are gaining popularity due to their use for controlled release and targeted drug delivery. The microsponge delivery system (MDS) is a patented polymeric system consisting of porous microspheres typically 10-25 microns in diameter, loaded with an active agent. They are tiny sponge-like spherical particles that consist of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface through which active ingredient is released in a controlled manner. Microsponge also hold a certification as one of the potential approaches for gastric retention where many oral dosage forms face several physiological restrictions due to non-uniform absorption pattern, inadequate medication release and shorter residence time in the stomach. This type of drug delivery system which is non-irritating, non-allergic, non-toxic, can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as gel, cream, liquid or powder that is why it is called as a “versatile drug delivery system”. It overcomes the drawbacks of other formulations such as frequency of dosing, drug reaction, incompatibility with environmental condition. These porous microspheres were exclusively designed for chronotherapeutic topical drug delivery but attempt to utilize them for oral, pulmonary and parenteral drug delivery were also made. The present review elaborates about the multifunctional microsponge technology including its preparation, characterization, evaluation methods along with recent research and future potential.
FACTORS AFFECTING THE INCIDENCE OF RABIES DISEASE IN PUSKESMAS REJOSARI PEKANBARU CITY
Authors: Parlin Winda
Published: May 2019

Rabies is a disease caused by the rabies virus. Rabies attacks can cause death. Based on data from Pekanbaru City Health Department found that the highest rabies cases were 15 cases in Puskesmas Rejosari. The purpose was to determine the factors that influence the incidence of rabies. This research is quantitative analytical research with case control design.  The respondents are 30 divided by 15 cases of rabies and 15 people as a control. Data were analyzed using univariate and bivariate with chi square test.The results are there is a relationship between the bite of animal with the rabies incidence (p value 0.01) and OR = 5, there is a relationship between knowledge with the rabies incidence (p value 0.005) and OR = 8, there is a relationship between attitude with the rabies incidence (p value 0.004) with OR = 9.000, there is a relationship between preventive action with rabies incidence (p value 0.000) with OR = 3.Conclusions: factors that influencing rabies incidence are animals bite, knowledge, attitude, and preventive action. Suggestion: There should be held education promotion about rabies and monitoring of families who raise animals that can transmitted rabies in Puskesmas Rejosari by local health authorities

 

Rabies merupakan penyakit yang disebabkan oleh virus. Rabies menyebabkan kematian. Berdasarkan data dari Dinas Kesehatan Kota Pekanbaru ditemukan bahwa kasus rabies tertinggi berada di Wilayah Kerja Puskesmas Rejosari yaitu sebanyak 15 kasus. Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor apa yang mempengaruhi kejadian di Wilayah Kerja Puskesmas Rejosari. Penelitian ini bersifat kuantitatif analitik dengan desain penelitian kasus kendali.  Jumlah  responden adalah 30 orang, terbagi dalam 15 orang  kasus rabies dan 15 orang sebagai kendali. Analisa data menggunakan analisa univariat dan bivariate dengan uji chi square. Hasil penelitian mendapatkan bahwa terdapat hubungan antara gigitan hewan dengan kejadian penyakit rabies (p value 0.01) dengan OR = 5, terdapat hubungan antara pengetahuan dengan kejadian penyakit rabies (p value 0.005) dengan OR = 8, terdapat hubungan antara sikap dengan kejadian penyakit rabies (p value 0.004) dengan OR = 9.000, terdapat hubungan antara tindakan pencegahan dengan kejadian penyakit rabies (p value 0.000) dengan OR = 3. Kesimpulan : Faktor yang berpengaruh dengan kejadian rabies di wilayah kerja Puskesmas Rejosari adalah gigitan hewan, pengetahuan, sikap, dan tindakan pencegahan. Saran : Sebaiknya diadakan penyuluhan mengenai penyakit rabies serta dilakukan pemantauan pada keluarga yang memelihara hewan penular penyakit rabies di Puskesmas Rejosari oleh petugas kesehatan setempat.
DFT-based calculations of silicon complex structures in the KF-KCl-K2SiF6 and KF-KCl-K2SiF6-SiO2 melts
Authors: Vorob’ev Alexey , Isakov Andrey , Galashev Alexander , Zaikov Yuri
Published: May 2019

The length and energy of bonds in the complex anions of silicon formed in KF?KCl?K2SiF6 and KF?KCl?K2SiF6?SiO2 melts were evaluated using the method of first-principles molecular dynamics, accomplished by means of the Siesta program. The effect of K+ (from the second coordination sphere) on the stability of these complexes was studied. The bond lengths in the silicon complexes was found to change with increasing amount of the potassium ions. It was established that the following complexes [SiO4]4-, [SiO3F]3- and [SiF6]2- are the most stable in KF?KCl?K2SiF6 and KF?KCl? ?K2SiF6?SiO2 melts. The [SiO4]4- and [SiF6]2- complexes are thermally stable in the molten salt in the temperature range of 923?1073 K, whereas the [SiF7]3- structure, which is typical for the lattice of crystalline K3SiF7, is unstable in this temperature range. In the KF?KCl?K2SiF6?SiO2 melts, conditions above 1043 K were created allowing the transformation of [Si?3F]3- into [SiO4]4-. Within the studied temperature mode, the Si?F bond length is in the range 1.5? ?1.9 ? and the Si?O bond lengths is 1.5?1.7 ?. The obtained results are in a good agreement with in situ data of Raman spectroscopy for the KF?KCl?K2SiF6 and KF?KCl?K2SiF6?SiO2 melts.
Neuropathy May Be an Independent Risk Factor for Amputation After Lower-Extremity Burn in Adults With Diabetes
Authors: Sen Soman , Barsun Alura , Romanowski Kathleen , Palmieri Tina , Greenhalgh David
Published: May 2019

IN BRIEF Treatment of lower-extremity burn injuries in adults with diabetes can be complex, and some diabetes-related factors can lead to impaired healing of such wounds, putting patients at risk of amputation. In this retrospective review of adult patients with lower-extremity burns, patients with pre-injury neuropathy and higher A1C levels were more likely to require amputations after their burn injury. The authors conclude that lower-extremity burn injuries in patients with diabetes require close follow-up and possibly referral to a burn specialist for interventions and treatment strategies to offset more serious complications.
Engineering Publics: The Different Modes of Civic Technoscience
Authors: Dickel Sascha , Schneider Christoph , Thiem Carolin , Wenten Klara-Aylin
Published: May 2019

Amongst the many modes of citizen science in the past years TechnoCitizenScience has emerged. In this paper we argue that it is necessary to distinguish between science and technoscience since they are based upon different practices and goals. Whilst 'science' tries to explain the world, 'technoscience' tries to technologically construct worlds. Whereas citizen science involves publics to contribute to data gathering and interpretation, TechnoCitizenScience involves publics in technological world making. The article analyses three different cases of TechnoCitizenScience in a FabLab, a professional Makerspace and a civic hackathon. Whilst particular similarities such as discourses of inclusion and engineering rationalities guide these activities we show that TechnoCitizenScience takes place in diverse settings to fulfill different agendas. By creating prototypes for engineering publics TechnoCitizenScience expands the regime of technoscience into society.