bluuebunny/crossref_metadata_2025 huggingface dataset:
High expression of LipL21 protein of Iranian Leptospira interrogans in E. coli, applicable for diagnostic ELISA
Authors: Kamalzadeh K. , Esmaelizad M. , Ghalani J. , Khaki P. , Tebianian M.
Published: September 2023

Leptospirosis is an emerging infectious zoonotic disease caused by pathogenic Leptospira. The disease is more prevalent among farmers in hot and humid areas of Iran. Lack of clear clinical signs have impeded the diagnosis of leptospirosis. In this study, we attempted to produce a recombinant LipL21 protein of Leptospira based on a dominant pattern of Iranian isolates and to evaluate it in ELISA test. One hundred and sixty-two complete sequences of LipL21 available in GenBank until January 1, 2019 were compared. One dominant LipL21 protein pattern was selected. The codon optimised sequence was cloned into the pET32a+ expression vector. Trx-LipL21 fusion protein was induced, purified and confirmed by 10% SDS-PAGE followed Coomassie blue staining and immune blotting. For evaluation of effectiveness of rLip21 in ELISA test, 200 µg rLip21 with Montanide ISA70 adjuvant was injected subcutaneously in rabbits three times. Results showed that rLipL21 protein was highly expressed in 2YT media in presence of 0.1 mM IPTG after 16 hours incubation at 37 oC. Recombinant protein was purified 36 mg per liter using affinity batch formation method by Ni-NTA resin. ELISA with micro plate coated with 250 ng rLipL21 protein demonstrated prominently diffe­rences between test and control groups (P<0.01). The rLipL21 protein produced large amounts of antibodies in the rabbit. The protein was also able to detect high levels of antibody in animals immu­nised with Leptospira vaccine. The rLipL21 might be a good candidate for diagnosis and evaluation of antibody levels against Leptospira.
Antibacterial and antibiofilm activities of novel antimicrobial peptides against Pseudomonas aeruginosa isolates from bovine mastitis
Authors: Aflakian F. , Rad M. , Hashemitabar Gh. , Lagzian M. , Ramezani M.
Published: September 2023

Pseudomonas aeruginosa is one of the causative pathogens of bovine mastitis. Most of P. aeruginosa cells can form biofilm, thereby reducing antibiotic efficacy which has become a significant public health challenge nowadays. In the present study, biofilm formation of 50 isolates was assessed. The inhibitory effect of three designed antimicrobial peptides (FASK, YDVD, WSF) on P. aeruginosa planktonic growth and biofilms was evaluated. The minimum inhibitory concentration (MIC) of all the peptides under study was 1600 µg/mL. The synthetic compounds had a significant inhibitory effect at concentrations of 1/2 MIC (800 µg/mL) and 1/4 MIC (400 µg/mL) on biofilm formation of these isolates, and showed anti-biofilm activity at a lower concentration than MIC. Antibacterial peptides FASK, YDVD with 70% antibiofilm effect and WSF with 60% effect prevented the formation of biofilm by mastitis isolates at a concentration of 1/2 MIC. The peptides of this study are promising candidates for inhibiting P. aeruginosa biofilm formation.
IMPLEMENTATION OF INTEGRATED REENGINEERING SYSTEMS IN BIO-ENTERPRISES IN THE PANDEMIC CONDITIONS
Authors: Nikolova-Alexieva V. , Alexieva I. , Valeva K.
Published: September 2023

The impact of COVID-19 on business is reflected in declining sales, profits, and employment. One of the most effective tools of crisis management is reengineering, which allows for innovation and flexibility, and adaptability. Integrated reengineering systems allow the bio-enterprises to effectively organize the operation of business procedures, as well as to ensure transparent processing of financial data and to manage production processes, orders, payments, and all activities in the enterprise. Integrated reengineering systems allow managers to share integrated information about the company so that they can make better decisions based on more complete and accurate company information. The main purpose of the report is to present the results of a study in which the main focus is on the ability of Bulgarian bio-enterprises to apply reengineering as a tool of crisis management and the main barriers to implementing integrated systems. Recommendations for their optimal overcoming are proposed
Presentation of the dossier “Political-religious conflicts in Antiquity and the Middle Ages”
Authors: Sotocorno Ana Carolina Picoli , Rodrigues, tradução de João Batista Ribeiro Santos Thaís De Almeida
Published: September 2023

Antiquity and the Middle Ages encompassed numerous transformations in the political-religious field. We attest in the longue durée of these archaeological periods the existence of several religious practices, as well as numerous conflicts.
Fictio personae: O uso retórico do potencial mágico dos mortos no Pro Caelio de Cícero
Authors: Feitosa Paulo Marcio
Published: September 2023

Na literatura latina há, reconhecidamente, numerosos relatos, histórias, comentários e discussões sobre a morte e a presença dos mortos no cotidiano das cidades. Descrições sobre as procissões funerárias da elite, os rituais públicos e privados, além de uma gama de opiniões sobre o pós-vida, alma, espírito, deuses infernais e fantasmas – todos esses elementos faziam parte da realidade de lidar com a morte no mundo romano. Todavia, apesar de reconhecer a importância do aspecto religioso dos mortos, os cultos e práticas relativas aos mortos também possuíam uma relevância política. Proponho analisar como esse caráter político-religioso dos mortos foi utilizado pelo orador Cícero, ao evocar retoricamente os mortos durante a Defesa de Célio.
Convertendo-se na Videira Verdadeira - A Imagética Dionisíaca em Contexto Cristão na Antiguidade Tardia
Authors: Malafaia Carvalhaes de Figueiredo Lucas
Published: September 2023

Este artigo busca analisar a coexistência entre as iconografias dionisíaca e cristã na cultura material da Antiguidade Tardia. Buscar-se-á demonstrar como a análise das fontes materiais nos permite dissipar uma imagem das relações entre cristãos e pagãos pautada exclusivamente por uma dinâmica conflitiva. Estratégias não apenas de repúdio, mas sobretudo de acomodação de elementos provindos do paganismo por parte dos cristãos serão analisadas em relação ao pano de fundo da cultura comum compartilhada entre os diferentes habitantes do Império. Propõem-se aqui que a incorporação cristã de elementos visuais já presentes nesta cultura colaborou com a própria estratégia de cristianização do Império.
Corpos em Disputa: os centros de culto e as relíquias de Pedro e Paulo no contexto da Antiguidade Tardia
Authors: Rodrigues dos Santos Vanessa De Mendonça
Published: September 2023

Nosso artigo tem como objetivo apresentar os três principais sítios de culto a Pedro e a Paulo, que se desenvolveram em Roma, e as questões e disputas surgidas em torno dos sítios e das relíquias dos apóstolos. Por meio de uma análise comparativa, buscamos refletir sobre as semelhanças e as diferenças na ocupação pelos cristãos da Necrópole Vaticana, da Necrópole Ostiense, e da região Ad Catacumbas, na Via Ápia, avaliando as principais problemáticas em torno do desenvolvimento dos locais, bem como suas transformações com o processo de monumentalização da devoção após a paz da Igreja. Também analisamos a documentação textual sobre esses espaços, a fim de discutir a importância que eles teriam para a igreja de Roma e para os cristãos, como um todo, sobretudo no contexto das disputas sobre a primazia da Sé romana em relação às demais.
Perspectives and current trends in the use of wooden structures in sustainable urban development
Authors: Hasanov Timur , Poshev Azrail , Kazikhanov Osman , Parchiev Suleyman , Tatriev Sultangiri
Published: September 2023

When designing the concepts of new neighborhoods, districts, cities and reconstruction of existing construction sites, one of the main tasks before the sphere of urban planning is the formation of a comfortable urban environment for living, leisure and work of the population. In the conditions of dense building with high-rise and multi-storey buildings, the most rational and innovative solution to improve the environmental friendliness of the urban environment is the introduction of the principles of sustainable development with energy-saving technologies, natural building materials and innovative designs. This article considers the status, trends and problems of development of wooden structures on the example of cross-laminated wood panels that help to reduce the negative impact of the construction sector on the environment in urban areas and dense development. The main reasons for the increased interest in the construction of multi-family wooden houses are indicated. The characteristics and unique properties of both the wood itself and the panels are described. The advantages offered by the innovative system of "green" construction with the use of cross-laminated wood panels are described. The authors analyze the competitiveness of laminated wood panels compared to traditional building materials such as concrete, stone and metal. The article describes the experience of implementation of innovative and sustainable building systems in foreign countries, the prospects and problems of further development of wooden house-building in the Russian construction industry, and also the priorities and methods of domestic manufacturers of laminated panels which will allow to provide additional volumes of consumption of laminated wood and mass construction of residential complexes. Further directions of research problems in the development of wooden structures are formulated.
Liquidity of the banking system: problems of regulation
Authors: Gedgafov Zalimgeri , Kanokova Karina
Published: September 2023

Within the framework of this article, the authors raise the issue of the development of the banking system. The article is devoted to the problems and peculiarities of the liquidity management of the banking system and its impact on the activities of banks. According to the authors, liquidity acts as the main indicator of the stability and reliability of banks. It is important that the level of liquidity is at a strictly defined level. Only under this condition the income of banks will be maximized. This explains the need to develop an effective mechanism for managing liquidity. The authors emphasize that in order to maintain liquidity, it is necessary to constantly maintain the ratio of its three main components: own, borrowed and placed funds. It is noted that the level of liquidity is largely determined by a combination of external and internal factors. The authors formulate a list of two types of factors that have the greatest impact on the state of liquidity. The article emphasizes that there is a very close relationship between liquidity and profitability: with an increase in the liquidity of assets, the risk associated with them decreases, which means that the profitability from the sale of these assets also decreases. The authors also consider the main methods of asset and liability management and list their features. However, it should be understood that the most effective management of the liquidity of the banking system can be achieved only with the integrated management of both assets and liabilities. The authors argue that a number of problems may arise in the process of liquidity management. In this regard, they are developing measures to overcome these problems. In addition, a list of those aspects that need to be given more attention in the management of liabilities is given.
Implementation of the ESG agenda and achievement of sustainable development goals in Russia
Authors: Khudov Ilya
Published: September 2023

This scientific work is devoted to the study of global problems of our time. The transition to the concept of sustainable development is one of the urgent tasks facing the entire world community. Following the concept of sustainable development, and especially its environmental aspects, is a strategic necessity in the context of modern global problems. The authors also considered in detail the following key areas: the raw material problem of transition to the concept of sustainable development, global environmental problems and their main forms of manifestation, demographic challenges to sustainable development, the food problem in the context of the concept of sustainable development. Based on the analysis, the authors have identified the key environmental problems of our time: the depletion of the planet's natural resources, environmental pollution and climate change. The fight against the identified problem areas is necessary, since environmental problems are relevant for all representatives of the world community, while in the process of human activity they only worsen. In addition, following the concept of sustainable development implies the implementation of state environmental regulation, as a result of which business conditions become more complex, and the private sector is forced to adapt to new realities. For sustainable development, it is necessary that the growth rate of food production be greater or at least equal to the growth rate of the population, however, due to existing problems, in particular related to demographic, food and environmental crisis phenomena, an imbalance has been formed between the components under consideration. In the final part, the authors formulate conclusions regarding the impact of environmental problems of our time on the possibility of transition to the concept of sustainable development, and also put forward an assumption: in order to transition to the concept of sustainable development, it is necessary to minimize the impact of negative factors that worsen the environmental situation.
Key features of the control environment of 1C CJSC and proposals for its improvement
Authors: Vasiliev Alexey
Published: September 2023

This scientific work deals with the issue related to the development of proposals for improving the control environment of 1C CJSC. The author studied the key provisions characterizing the specialization and activities of 1C CJSC, and also described the general ideas about the activities of this organization. In this scientific work, an analysis of the economic security system of 1C CJSC was carried out. At the same time, a number of shortcomings were identified that do not allow asserting the perfection of the economic security system in 1C CJSC. The author described the above problems, as well as put forward assumptions regarding the causes of their occurrence and further development. In addition, this article describes the mechanism for the formation of a system of risk indicators, which is formed on the basis of international regulations and principles.
An important place in this work is given to the analysis of the system of risk indicators that allow the analysis of the control environment of the organization. The author studied the main risk areas, among which threshold and critical values were noted, thanks to the definition of which it is possible to evaluate each risk indicator. In addition, this scientific work describes a number of indicators with examples of their calculation, as well as with the possibilities of their further interpretation to determine the state of the organization and its sustainability.
In the final part of the work, the author formed conclusions regarding the analysis of the system of risk indicators in 1C CJSC, and also put forward suggestions on how it is possible to improve the accuracy and depth of further analysis based on the transformation and change of indicators within the system.
Internal audit in a credit institution as a tool for improving the economic security of an economic entity
Authors: Kryazhkov Alexander
Published: September 2023

When writing this scientific article, the author considered the role of internal audit in the economic security of credit institutions. The formed conditions of instability of the economic system and negative external impact, manifested in sanctions pressure, mediate the need to increase the effectiveness of internal audit in credit institutions in order to increase the economic security of an economic entity. The author considers the definition of internal audit in accordance with the legislation of the Russian Federation, identifies the tasks of internal audit, as well as the prerequisites for the formation of an internal audit service in an organization, and the main functions of internal audit. Internal audit is an independent and objective activity of providing guarantees and consulting, which improves the activities of the organization and increases its value. The differences between internal audit and other forms of control are highlighted. It is important to note that internal audit occupies one of the most important roles in the structure of the organization and is in constant interaction with the system of economic security of the organization. Internal audit is considered the foundation of the organization and is considered as a key element for the application of the accounting system. Effective internal audit planning allows audit activities to be one of the aspects that protects the organization and increases economic security. Moreover, effective internal audit planning and prioritization of the units to be audited are important both from the point of view of the effective use of internal auditors and from the point of view of the effective use of economic resources. Thus, the tasks assigned to the study can be considered completed. The problems of the research topic were fully developed, a block of relevant information was presented and analyzed for each of the tasks, and appropriate conclusions were drawn.
Ethical transformation and legal boundaries of economic intelligence
Authors: Lebedev Igor , Prasolov Valery
Published: September 2023

Within the framework of this article, the authors considered the issue of economic intelligence in modern conditions. Against the backdrop of the economic confrontation between Western countries and Russia, it becomes obvious that the concept of economic intelligence is changing, manifesting itself in several planes at the same time, and corporate confrontation is moving to the level of protecting national interests. According to the authors, the factors affecting the perception of the methods of corporate confrontation are subject to change. Based on the assumption that the methods and tactics of economic intelligence are not static, the authors in this study set himself the task of determining the factors that influence their ethical perception. The study provides an opinion that the transformation of approaches to understanding ethical behavior and the very definition of ethical behavior in economic intelligence is directly related to the technological aspect, the transition of many business processes to the digital plane. The authors focus on the fact that in the conditions of cyberspace the psychological perception of illegal actions changes significantly. Commitment to ethical behavior may naturally decrease due to the lack of personal contact between the agent of influence and the source. At the same time, in practice, the boundary separating ethical and unethical methods of conducting competitive intelligence remains very unclear, which creates additional difficulties in countering such methods. In the final part of the article, the authors formulate a conclusion regarding the most common threats to which corporate data is exposed, as well as the role of economic intelligence in ensuring the security of an organization.
Analysis of the practical use of information asymmetry in financial markets
Authors: Shishkov Petr , Kanaeva Maria , Lozhechko Aleksandr
Published: September 2023

This article discusses the issue of minimizing the negative consequences in different types of financial markets caused by such a phenomenon as information asymmetry. This problem is generated by the market participants themselves and can manifest itself in two directions, which are described in more detail in the article. The most common problems caused by information asymmetry, according to the author, are "bad choice" and "moral hazard". The author argues that the most optimal way to minimize negative consequences is state regulation, legislative consolidation of completely new forms of reporting to potential investors, tracking and suppressing fraud in this matter. The article pays special attention to the analysis of foreign experience in the field of resolving problems caused by information asymmetry, since some of them have made a significant contribution to reducing the imperfection of information in financial markets. The author cites as an example the creation of such companies as, for example, Fitch, Standard and Poor's, Moody's, the purpose of which is to study the financial market to identify reliable organizations. However, according to the author, the creation of financial intermediaries has become the most effective method of reducing information asymmetry in international practice. The essence of this method is described in detail in the article. An equally effective method is such a market mechanism as signals, which was developed by M. Spence. In the final part of the article, the author analyzes the problems arising in connection with the asymmetry of information in Russia, and also formulates conclusions regarding the role of the considered methods in ensuring the efficient operation of markets.
State support of the agro-industrial complex as a way to implement the policy of import substitution and development of foreign economic activities
Authors: Skripkin Ivan , Chudnovets Eva , Lozhechko Aleksandr
Published: September 2023

The topic of state support for the agro-industrial complex is especially relevant in the face of sanctions pressure and destabilization of the domestic economy. The purpose of writing this paper is to identify measures of state support for the agro-industrial complex as part of the implementation of the strategy of import substitution and the development of foreign economic activity of domestic companies. The author analyzes the theoretical foundations of import substitution and foreign economic activity as categories of scientific analysis, reveals the specifics of the concepts under consideration and the current conditions for the implementation of state support for the agro-industrial complex. On the basis of the analysis, the author identified the directions of the state implementation of measures that regulate foreign economic activity. The principles and legal frameworks of administration and control of the foreign economic activity of domestic companies are studied, it is revealed that at the present stage the volume of agricultural products stocks is sufficient to implement the import substitution strategy and ensure the development of foreign economic activity. It is important to note that when considering the dynamics of grain production in the period from 2017 to 2021, the author revealed that Russia in the 2020/21 agricultural year remains the largest exporter of wheat, while experts argue that the upward trend will continue in the medium term. To implement the import substitution strategy and develop the foreign economic activity of domestic companies, it is necessary not only to provide them with support from the state, but also to implement a policy aimed at improving the quality of domestic products — this will not only increase the competitiveness of domestic companies, but also improve their foreign economic activity. In conclusion, the author formulates conclusions regarding the foreign economic activity of domestic companies in the segment of agro-industrial production on the example of the export of fish products.
Monitoring and analysis of the effectiveness of internal control of a commercial organization
Authors: Chernyshov Daniil
Published: September 2023

The author of this scientific work analyzed the key mechanisms associated with the internal control process used in Russian and foreign practice. Based on the fact that the word "control" is interpreted differently in Russian and foreign practice, the author proposed his own definition of internal control, based on a combination of elements from the existing definitions of the concept under consideration. Internal control in the organization is divided into financial, economic, economic, as a result of which this process acts as a complex phenomenon. The main principles of economic control defined in the regulations were considered. In addition, all the methods used by internal control can be divided into methods of actual control and methods of documentary control. In Russian practice, a broad classification of internal control is carried out by the time of implementation, by completeness of coverage, by frequency, in relation to the audited organization. Among the normatively fixed elements of internal control, the control environment, risk assessment, internal control procedure, information and communication, and assessment of internal control stand out. The author established the relationship between the types of economic control, namely organizational and technical, administrative and financial, and the forms of control, which include thematic verification, revision, audit and accounting verification. The paper considers the key foreign concepts of internal control, which include COSO, COBIT, SAC, SAS/ISA. The author highlighted the similarities and differences between these approaches, during which it was revealed that basically all the concepts of internal control differ from each other in the object of observation.
Violación de derechos humanos Juliaca Perú – 2023
Authors: Condori María Del Pilar Calcina , Huancco Yulisa Elena Ccapa
Published: September 2023

De los hechos que ocurrieron en las Manifestaciones y Protestas, en la Región Puno el 09 de enero del 2023. En la cual el objetivo principal, fue analizar las causas y circunstancias en las que ocurrieron las muertes, producto de las manifestaciones y protestas. No se trata de forzar culpabilidad, si no de esclarecer de manera imparcial y objetiva el ¿por qué, de las muertes? Precisar los delitos en los que pudo haber incurrieron las fuerzas armadas y tipificarlos adecuadamente. Se trabajo partiendo de la base de los veinte fallecidos que hubo, aquel fatídico día, del número de heridos, se citaron de forma aproximada, ya que muchos de los heridos fueron atendidos en establecimientos de salud privados. Se analizo las circunstancias en las que ocurrieron los decesos, haciendo hincapié de forma individualizada, las causas de muertes; las mismas que fueron en mayoría por herida de bala, según: “Informe de Necropsia”, y datos y documentación recolectada tanto de familiares de las víctimas, así como de medios de comunicación y páginas web especializadas.
ADORAÇÃO E ENCANTAMENTO NAS POLÍTICAS PÚBLICAS DE JUVENTUDE
Authors: Brandão Marcílio Dantas
Published: September 2023

Enfocando duas emoções, este paper reflete sobre como elas impactam o planejamento e a execução de ações que visam gerar benefícios para pessoas jovens. O trabalho se fundamenta, por um lado, na revisão conceitual acerca da noção de políticas públicas de / para / com jovens e na apresentação de uma abordagem das ciências sociais sobre emoções; por outro lado, recupera-se a discussão de duas emoções místicas, adoração e encantamento, sobre as quais se discute como elas incidem em algumas políticas públicas de juventude no Brasil. O paper apresenta uma ampla concepção pragmatista do que vem a ser “política pública”, com isso tenta demonstrar como ações englobadas nas concepções de “protagonismo juvenil” e “associativismo com jovens” são eivadas de adoração e encantamento e contribuem – mesmo que não intencionalmente – para transferir aos próprios jovens atribuições que são responsabilidade de diversos setores da sociedade e do Estado, segundo a Constituição Federal do Brasil.
Characterization of 3D-printed graphene-reinforced PLA scaffold for bone regeneration
Authors: Karthic Manoharan , Chockalingam Kunjan , Vignesh Chandran , Nagarajan K Jawaharlal
Published: September 2023

In orthopedic application, bone tissue engineering (BTE) is a novel treatment method for bone defects involving bone regeneration using an artificial supporting structure called scaffold. The aim of this work is to fabricate graphene-reinforced poly(lactic acid) (PLA/Gr) scaffolds with different pore shapes (circular, square and hexagonal) and different pore sizes (1000, 1500 and 2000 μm) using the fused deposition modeling process. The characteristics of the three-dimensionally (3D) printed PLA/Gr scaffolds were analyzed through Fourier transform infrared spectroscopy, thermogravimetric analysis, derivative thermogravimetry, scanning electron microscopy and energy-dispersive X-ray spectroscopy. The water contact angle measurement showed a hydrophilic surface (70 ± 2.7°) for scaffolds with a pore size of 1000 μm. Mechanical property studies showed that the scaffold with circular 1000 μm pores had a compressive strength of 18.53 ± 0.90 MPa, which was similar to the cancellous bone value. In addition, this study involved an examination of the in vitro bioactivity, water uptake and biodegradation characteristics of the scaffolds. The results reveal that the 3D-printed PLA/Gr scaffold featuring a circular pore shape with a pore size of 1000 μm exhibits great potential as an implant for BTE.
Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model
Authors: Chen Changhan , Xie TingTing , Zhang Yujin , Wang Yiyan , Yu Fang , Lin Lizhen , Zhang Weiru , Brown Benjamin C. , Zhang Xin , Kellems Rodney E. , D'Alessandro Angelo , Xia Yang
Published: September 2023

Significance Statement

Hypoxia drives kidney damage and progression of CKD. Although erythrocytes respond rapidly to hypoxia, their role and the specific molecules sensing and responding to hypoxia in CKD remain unclear. In this study, we demonstrated in a mouse model that erythrocyte ENT1-AMPD3 is a master energy regulator of the intracellular purinergic hypoxic compensatory response that promotes rapid energy supply from extracellular adenosine, eAMPK-dependent metabolic reprogramming, and O2 delivery, which combat renal hypoxia and progression of CKD. ENT1-AMPD3-AMPK-BPGM comprise a group of circulating erythroid-specific biomarkers, providing early diagnostic and novel therapeutic targets for CKD.

Background

Hypoxia drives kidney damage and progression of CKD. Although erythrocytes respond rapidly to hypoxia, their role and the specific molecules sensing and responding to hypoxia in CKD remain unclear.

Methods

Mice with an erythrocyte-specific deficiency in equilibrative nucleoside transporter 1 (eEnt1

−/−
) and a global deficiency in AMP deaminase 3 (Ampd3

−/−
) were generated to define their function in two independent CKD models, including angiotensin II (Ang II) infusion and unilateral ureteral obstruction (UUO). Unbiased metabolomics, isotopic adenosine flux, and various biochemical and cell culture analyses coupled with genetic studies were performed. Translational studies in patients with CKD and cultured human erythrocytes examined the role of ENT1 and AMPD3 in erythrocyte function and metabolism.

Results

eEnt1

−/−
mice display severe renal hypoxia, kidney damage, and fibrosis in both CKD models. The loss of eENT1-mediated adenosine uptake reduces intracellular AMP and thus abolishes the activation of AMPKα and bisphosphoglycerate mutase (BPGM). This results in reduced 2,3-bisphosphoglycerate and glutathione, leading to overwhelming oxidative stress in eEnt1

−/−
mice. Excess reactive oxygen species (ROS) activates AMPD3, resulting in metabolic reprogramming and reduced O2 delivery, leading to severe renal hypoxia in eEnt1

−/−
mice. By contrast, genetic ablation of AMPD3 preserves the erythrocyte adenine nucleotide pool, inducing AMPK-BPGM activation, O2 delivery, and antioxidative stress capacity, which protect against Ang II-induced renal hypoxia, damage, and CKD progression. Translational studies recapitulated the findings in mice.

Conclusion

eENT1-AMPD3, two highly enriched erythrocyte purinergic components that sense hypoxia, promote eAMPK-BPGM–dependent metabolic reprogramming, O2 delivery, energy supply, and antioxidative stress capacity, which mitigates renal hypoxia and CKD progression.
Власть коммуникации
Authors: Кастельс Мануэль
Published: September 2023

Книга одного из крупнейших социологов современности Мануэля Кастельса, известного российскому читателю по опубликованным ранее произведениям, представляет собой поистине энциклопедию «работы» власти в современном пронизанном медиа мире. Автор дает практически исчерпывающее представление как о современном политическом процессе, существующем только через посредство медиа, так и об используемых последними способах привлечения общественного внимания (самого дорогого ресурса сегодня!), среди которых одним из наиболее популярных оказывается скандал. М. Кастельс отталкивается от последних достижений нейронауки в изучении эмоционального интеллекта, позволяющих успешно использовать техники так называемой каскадной активации, фрейминга, прайминга и других методов воздействия на зрителя/читателя/слушателя. Для подтверждения своих идей он использует как американские реалии, так и политические процессы в разных странах мира. Особый интерес представляет заключительная глава, посвященная первой президентской избирательной кампании Барака Обамы, успех которой в решающей степени был обусловлен прорывным решением его избирательного штаба об активнейшем использовании социальных медиа. Несмотря на сугубо академический характер (только библиография занимает 48 страниц), множество диаграмм и таблиц, что делает книгу незаменимым подспорьем в профессиональной практике политологов, прекрасным компендиумом и «точкой роста» для студентов, она представляет значительный интерес и для широкой читательской аудитории, поскольку написана увлекательно и прекрасным языком. Подготовлено в рамках проекта ВШЭ по изданию переводов учебной литературы.
N95 MASKE KULLANIMININ RETİNA DAMAR DANSİTESİ ÜZERİNE ETKİSİNİN OPTİK KOHERENS TOMOGRAFİ ANJİYOGRAFİ İLE DEĞERLENDİRİLMESİ
Authors: ÇOMÇALI Sebile , YILMAZ Uğur , KILIÇ Raşit , COŞKUN Çiğdem , ÇAVDARLI Cemal , ALP Mehmet Numan
Published: September 2023

Amaç

Sağlık çalışanlarında FFP2/N95 yüz maskesinin oksijen

satürasyonu (SpO2), maküla ve optik disk damar

dansitesi üzerindeki etkisinin optik koherens tomografi

anjiyografi (OKTA) ile değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntem

Çalışmaya 19 gönüllü sağlık çalışanının 38 gözü dahil

edilmiştir. Tam oftalmolojik muayeneleri yapılmıştır.

N95 maske takılmasından hemen önce ve 4 saat sürekli

kullanımından hemen sonra oksijen saturasyonunu

değerlendirmek için parmak tipi puls oksimetre ve

optik disk ile retinal damar dansitelerini değerlendirmek

için Angiovue OKTA cihazı kullanılmıştır. Katılımcılardan

bu süre içerisinde maskelerini çıkarmamaları

istenmiştir. OKTA ile maske takılmadan ve çıkarılmadan

hemen önce maküla ve optik disk damar dansiteleri

değerlendirilmiştir.

Bulgular

Çalışmaya dahil edilen 19 gönüllünün 15’i kadın, 4’ü

erkekti. Ortalama yaş 36,64 ± 9,3 yıldı. Tüm gözlerde

Snellen’e göre düzeltilmiş görme keskinliği 20/20

idi ve tümünün göz içi basınç ölçümleri normal sınırlardaydı.

N95 maske takılmadan önceki oksijen satürasyonu

%97,94 ± 0,8, dört saat kullanım sonrasında

ise %96,14 ±1,8 idi. Maske kullanımı sonrası santral

maküla kalınlığında (SMK) anlamlı artış (p
Gas Detection and Classification Using Neural Network Based Gas Sensors
Authors: Ismail Munaf , Dwi Prasetyowati Sri Arttini
Published: September 2023

Alcoholic beverages, apart from being haram, also cause loss of consciousness. The influence of alcohol while driving is very dangerous and can result in an accident. For this reason, it is necessary to detect the alcohol content in beverages so that their halal status is known and to avoid the dangers of consuming alcohol. This research is to detect the aroma of alcohol using the MQ-3 gas sensor, which consists of an aroma sensor in general with an Artificial Neuron Network (ANN), such as the number of neurons, layers, and epoch. Most of the learning schemes require testing to optimize the model structure. For this experiment, ANN is used as a liquid classification in grouping alcoholic and non-alcoholic liquids. The MQ-3 gas sensor successfully reads liquid vapor in alcohol with levels of 30%, 50%, 70%, and other water-based liquids. An artificial neural network with 2 hidden layers, 10 neurons, and 1000 iterations with the sigmoid activation function can approach a regression score of 1.1545 and sq error score of 0.5781.
Detection of Intermittent Oscillation in Process Control Loops with Semi-Supervised Learning
Authors: Ibrahim Nova Zidane , Wardana Awang Noor Indra , Arif Agus
Published: September 2023

Oscillations in the control loops indicate the poor performance of the control loops. The occurrence of oscillations in the process control loop is quite high in the industry, so it needs to be reduced so that the control loop can work properly. The first step for oscillation reduction is oscillation detection. One type of oscillation that is difficult to detect is intermittent oscillation. The smart factory concept encourages the development of the intermittent oscillation detection system using machine learning by being implemented online. Therefore, in this study an online intermittent oscillation detection program is built using K-nearest neighbor (KNN)-based Semi-supervised learning (SSL) method. The SSL method applied is self-training. The training data was obtained by a simulation of the Tennessee Eastman Process. The data is segmented based on window size and extracted time series features. The extracted data is used to build a model to detect oscillations caused by stiction, tuning errors, and external disturbances in the reactor. The model is implemented online with sliding windows and MQTT. The best accuracy and F1-score of the model obtained are 96.15% and 95.15%. In online detection, the model detects the type of oscillation with an average time of 305 seconds.
Artificial Intelligence-Based Digital Transformation for Sustainable Societies: The Prevailing Effect of COVID-19 Crises
Authors:   Lebanese American University, Tarhini Abbas , Harfouche Antoine ,   University Paris Nanterre, Marco Marco De ,   Università Internazionale Telematica
Published: September 2023

Digital transformation (DT) is becoming a necessity for enterprises in different industries all over the world. The necessity for DT turned out to be inevitable with the coronavirus (COVID-19) outbreak. On March 2020, the World Health Organization (WHO) announced the COIVD-19 as global pandemic that caused thousands of deaths and brought the world to a standstill with huge economic burden (World Health Organization, 2020). This pandemic accelerated the need for organizations to transform using extensive digitization in response to the unprecedented change (Morgan, 2020). However, significant obstacles still encounter these organizations when it comes to recommending the necessary changes to make the digital leap. In today’s artificial intelligence age, digital transformation has enormous impact across societies (Nambisan, 2019; George & Paul, 2020; Majchrzak, Markus, Wareham, 2016); organizations need to realize that both digital transformation and artificial intelligence have to go hand in hand to help achieve prosperous digital transformation (Wuest et al., 2020). Therefore, becoming a digital enterprise is much more than investing in latest digital technologies. It is about adopting artificial intelligence to support the business strategy (Joda et al. 2020), searching for new business models (Kotarba, 2018), and considering afresh how to embed the social impact in the measure of the success of the business.
Team Leadership and Diversity Management in Information Systems Development Project Teams
Authors:   University of Massachusetts at Dartmouth, Li Yuzhu , Hsu Jack Shih-Chieh ,   National Sun Yat-Sen University, Sun Hua , ,   Shandong University, Parolia Neeraj ,   Towson University
Published: September 2023

Background: The interplay of diversity and leadership produces mixed findings in the literature. Based on the categorization-elaboration model (CEM) and diversity management (DM) literature, this study investigates the role of team leadership in a diverse ISD team. Further, this study examines the moderating roles of DM practices in the relationships between group diversity, team leadership, and project performance. Method: This study selected a paired survey method to test the hypotheses. Eighty-two valid paired questionnaires were received from project managers and team members in ISD projects. In addition, this study used partial least squares (PLS) with a bootstrapping technique to examine the proposed model. Results: The results show that group diversity has mixed impacts on team leadership. Furthermore, DM practices positively moderate the effect of value diversity on team leadership, as value diversity is positively related to team leadership when DM practices are more robust. At last, DM practices negatively moderate the relationship between team leadership and project performance as the effect of team leadership has weaker effects on project performance when DM practices are strong than when the practices are weak. Conclusion: This study adds to the literature by examining team leadership in a heterogenous ISD team and providing empirical evidence for the moderating roles of DM practices in team leadership processes.
Long Covid – Into the Third Year
Authors: Meagher Timothy
Published: September 2023

As the COVID-19 pandemic reaches the end of its third year, and as COVID-related mortality in North America wanes, long Covid and its disabling symptoms are attracting more attention. Some individuals report symptoms lasting more than 2 years, and a subset report continuing disability. This article will provide an update on long Covid, with a particular focus on disease prevalence, disability, symptom clustering and risk factors. It will also discuss the longer-term outlook for individuals with long Covid.
Correlates and Predictors of NT-proBNP in Life Insurance Applicants
Authors: Rigatti Steven J. , Stout Robert
Published: September 2023

Objectives.—To document the various laboratory and demographic/historical correlates of NT-proBNP levels in applicants for life insurance, and to explore the accuracy of a prediction model based on those variables.

Method.—NT-proBNP blood test results were obtained from 1.34 million insurance applicants between the age of 50 and 85 years, beginning in 2003. Exploratory data analysis was carried out to document correlations with other laboratory variables, sex, age, and the presence of relevant diseases. Further, predictive models were used to quantify the proportion of the variance of NT-proBNP, which can be explained by a combination of these other, easier to determine variables.

Results.—NT-proBNP shows the expected, negative correlation with estimated glomerular filtration rate (eGFR) is markedly higher in those with a history of heart disease and is somewhat higher in those with a history of hypertension. A strong, unexpected, negative correlation between NT-proBNP and albumin was discovered. Of the variables evaluated, a multivariate adaptive regression spline (MARS) model automated selection procedure selected 7 variables (age, sex, albumin, eGFR, BMI, systolic blood pressure, cholesterol, and history of heart disease). Variable importance evaluation determined that age, albumin and eGFR were the 3 most important continuous variables in the prediction of NT-proBNP levels. An ordinary least squares (OLS) model using these same variables achieved a R-squared of 24.7%.

Conclusion.—Expected ranges of NT-proBNP may vary substantially depending on the value of other variables in the prediction equation. Albumin is significantly negatively correlated with NT-proBNP levels. The reasons for this are unclear.
Infecciones asociadas a la atención de la salud posterior a procedimientos quirúrgicos en pacientes adultos: scoping review
Authors: Espinosa-Moreno Mario Fernando , Chaverra-Perdomo Lissy Carolina , Torres-Restrepo Juan Manuel , Gutiérrez-Ramirez David Ricardo , Medina-Rojas Rolando
Published: September 2023

Objetivo: Establecer las infecciones asociadas a la atención de la salud en pacientes intervenidos quirúrgicamente, sin tener en cuenta las infecciones del sitio operatorio (ISO). Materiales y métodos: Se realizó una búsqueda de la literatura en las bases de datos de MEDLINE, CENTRAL, LILACS además de la literatura gris, para identificar estudios relacionados con infecciones asociadas a la atención de la salud en pacientes adultos que fueron intervenidos quirúrgicamente. Resultados: En la búsqueda realizada se seleccionaron 25 artículos de los cuales se extrajeron los resultados. Las IAAS más frecuentes en los estudios revisados fueron: neumonía asociada al ventilador (36%), neumonía asociada al cuidado de la salud (32%), infecciones de tracto urinario por catéter urinario (48%), infecciones asociadas a catéter venoso (8%). Conclusión: Las infecciones asociadas a la atención de la salud frecuentemente encontradas en pacientes llevados a procedimientos quirúrgicos son la neumonía asociada al ventilador, neumonía asociada al cuidado de la salud, la infección del tracto urinario por catéter y las infecciones asociadas a catéter venoso, sin embargo, las infecciones de sitio operatorio (ISO) son las más documentadas, situación que requiere mayor atención y abordaje a través de otros estudios de investigación.
Transposición de la vena renal izquierda
Authors: Filizzola-Acosta Roberto Ernesto Máximo , Morales Diego Ruben , Matsumura Kiichiro , Romero Daniel Gerónimo , Acha Carlos Alberto
Published: September 2023

El Síndrome de Nutcracker producido por compresión aorto-mesenterica de la vena renal izquierda puede tratarse con transposición quirúrgica. Se realizó revisión de dicho tratamiento realizado en el Instituto de Previsión Social. Se identificaron dos mujeres de 15 y 26 años, que presentaron dolor lumbar y hematuria. Egresaron al cuarto y quinto día de postoperatorio. Las pacientes no presentaron síntomas a los cinco y nueve meses de seguimiento.
La Unión Europea frente al desafío de la guerra en Ucrania: ¿La ansiada epifanía de su política exterior y de seguridad común?
Authors: González Alonso Luis Norberto
Published: September 2023

La gestión de la crisis generada por la guerra en Ucrania está representando un test de estrés sin precedentes para la política exterior y de seguridad común de la Unión Europea, que nunca antes había tenido que enfrentarse a un escenario que tensionara hasta tal punto su configuración jurídica e institucional. Contribuir a la comprensión y valoración del alcance de este fenómeno constituye el objeto fundamental del presente estudio. Para ello, se tratará de rastrear el impacto de ese conflicto sobre la PESC en tres planos o estratos de análisis yuxtapuestos: atendiendo, en primer término, a su efecto de confirmación o revelación del grado de consistencia alcanzado ya por esta política de la Unión pese a su naturaleza singular; explorando, a continuación, hasta qué punto puede haber provocado el recurso a herramientas o potencialidades hasta ahora escasamente explotadas en el marco jurídico en vigor, y valorando, por último, si podría acelerar de algún modo los proyectos de fortalecimiento de la PESC por la vía de la reforma de los Tratados.