bluuebunny/crossref_metadata_2025 huggingface dataset:
The Ramparts We Watch: film documentary discourse in the field of Public Relations / The Ramparts We Watch: el discurso del cine documental en el campo de las Relaciones Públicas
Authors: Girona Ramon , Xifra Jordi
Published: August 2024

The aim of this article is to analyze Louis de Rochemont’s The Ramparts We Watch as a public relations war effort from the past century. Arising from the informative and propagandistic strategy of late 1930s newsreels, the aforementioned documentary was made using very appropriate narrative techniques to award it the dimension of objectivity and truthfulness characteristic of public relations messages, without losing sight of its educational and persuasive function. From this standpoint, The Ramparts We Watch founded a genre and constituted one of the clearest precedents of public relations war films in America.El objetivo de este artículo es analizar el film de Louis de Rochemont, The Ramparts We Watch, en tanto que un esfuerzo de relaciones públicas en tiempos de guerra. Surgido de la estrategia informativa y propagandística de los noticiarios de la segunda mitad de los años 30, este documental se realizó mediante el uso de técnicas narrativas muy adecuadas para conseguir la dimensión de objetividad y veracidad que debe caracterizar los mensajes de relaciones públicas, sin perder de vista su función educativa y persuasiva. Desde ese punto de vista, The Ramparts We Watch adquirió un carácter fundacional y constituyó uno de los más claros precedentes de los filmes de relaciones públicas realizados en Estados Unidos, en el contexto de la guerra.
Prat Gaballí y Juan Beneyto: Una Aproximación a la Introducción de la Disciplina de las Relaciones Públicas en España / Prat Gaballí & Juan Beneyto: an aproximation to introdution to the discipline of public relations in Spain
Authors: Reina Estevez Jesus , González España Mª Inmaculada
Published: August 2024

Este estudio trata sobre los inicios de las Relaciones Públicas en España, que se producen de la mano de un reducido grupo de profesionales, pertenecientes a otras áreas de la comunicación. A través de las obras de Prat Gaballí (Publicidad Combativa) y Juan Beneyto (Mass Communications y, Teoría y Técnica de la Opinión Pública), se reflexiona y estudian las primeras manifestaciones teóricas en torno a las Relaciones Públicas, en la creación de un incipiente cuerpo teórico, y su conformación como disciplina académica, a partir de los años cincuenta del presente siglo.
La producción bibliográfica sobre el etiquetamiento y conceptualización de los profesionales de la comunicación organizacional en España/ Bibliographic output on the labeling and conceptualization of organizational communication professionals in Spain
Authors: Miquel-Segarra Susana , Martín-LLaguno Marta
Published: August 2024

Durante las últimas décadas en España las necesidades en comunicación organizacional han crecido a un ritmo vertiginoso. Paralelamente, ha proliferado el debate sobre la consideración del ejercicio profesional de este tipo de comunicación, especialmente a partir del nacimiento de las titulaciones universitarias. Así, el concepto “relaciones públicas” y el de “Dircom” o “director de comunicación” parece que se utilizan simultáneamente no sin despertar todavía cierta controversia. Este artículo realiza una revisión sistemática de la literatura científica española sobre estos perfiles profesionales desde los años setenta, con el fin de describir los usos, diferencias y coincidencias que en ella se da de los términos antes citados. Los resultados apuntan que a partir de la década de los 90, el término “director de comunicación” se implanta en el ámbito profesional absorbiendo las funciones de “relaciones públicas” mientras que el ámbito académico sigue prefiriendo utilizar este segundo término.
Una aproximación histórica al dominio intelectual de las Relaciones Públicas. Tensiones paradigmáticas en su construcción disciplinar / A historical approach to the intellectual domain of public relations. Paradigmatic tensions in their disciplinary const
Authors: Sadi Gabriel , Méndez Verónica
Published: August 2024

El artículo se interesa por el desarrollo de las Relaciones Públicas en tanto campo intelectual, propiciando un acercamiento de índole paradigmática a las propuestas teóricas y conceptuales predominantes en los últimos 35 años. Con tal fin, se ha indagado en artículos de publicaciones científicas y en libros de editoriales reconocidas que hayan sido editados entre 1980 y lo que ha transcurrido de 2015, de modo tal de poner en evidencia las distintas visiones teóricas construidas en torno a la disciplina y establecer si es válido referir a la existencia de un paradigma dominante y enfoques alternativos
O campos acadêmicos em Comunicação Organizacional e Relações Públicas no Brasil: caracterização, pesquisa científica e tendências /The academic fields of Organizational Communication and Public Relations in Brazil: characterization, scientific research
Authors: Krohling Kunsch Margarida M.
Published: August 2024

Resumo   Este artigo  apresenta uma visão geral das Relações Públicas e da Comunicação Organizacional no Brasil e como estas  áreas estão sendo configuradas como espaço acadêmico de pesquisa e de geração de novos conhecimentos, destacando  aspectos da pós-graduação  com ênfase na produção científica gerada. Descreve uma investigação  científica sobre as teses de doutorado  e dissertações de mestrado defendidas nos programas de pós-graduação do país,  no período de 2000 a 2014. Trata-se de um estudo em construção, onde são explorados alguns aspectos sobre o volume, gênero, metodologia e temática desta produção. A partir dos dados obtidos são apresentadas  algumas análises e reflexões sobre  principais características  e tendências das temas  mais recorrentes que vêm vendo pesquisados pelos autores.   Abstract This paper presents an overview of the Public Relations and Organizational Communication areas in Brazil. It shows how these areas are being set up as academic spaces of research in Brazil,   highlighting aspects of postgraduate studies and emphasising the scientific production generated. It describes a scientific investigation on the doctoral and master's theses defended in the country's postgraduate programs from 2000 to 2014. It is a study under construction, which aims to explore some aspects related to volume, gender, methodology and thematics  of this production. Based on the data obtained some analysis and reflections on the main features and trends of the recurring themes in this field are presented.
Estudio de la presencia y uso de redes sociales de las agencias de comunicación que más facturan en España / Study about the social network presence and use of the communication agencies with the largest turnover in Spain
Authors: Rodríguez López María , Robles Álvarez Daniel
Published: August 2024

Las agencias de comunicación son empresas que se mueven en el terreno de las relaciones públicas, la publicidad, la comunicación audiovisual y el periodismo. Estas empresas deberían ser líderes en el uso de las nuevas herramientas de comunicación con las que contamos, como las redes sociales, ya que son empresas que se dedican a elaborar planes de comunicación, estrategias de comunicación para sus clientes y si ellas mismas no incluyen en sus estrategias el uso de herramientas sociales de comunicación de acuerdo a los tiempos en que vivimos, no están transmitiendo una buena imagen a sus clientes, ya que deben predicar con el ejemplo y contar con estrategias de comunicación completas en las que se tengan en cuenta las redes sociales y demás herramientas online. En este artículo estudiaremos a las agencias de comunicación que más facturan en España para comprobar si, efectivamente, hacen un buen uso de las nuevas herramientas de comunicación, especialmente de las redes sociales.
Relaciones Públicas y Comunicación Corporativa en los grados universitarios catalanes en el curso académico 2015-2016/Public Relations and Corporate Communication in the Catalan University Degrees during the Academic Year 2015-2016
Authors: Matilla Kathy , Hernández Salvador , Compte-Pujol Marc
Published: August 2024

En España, en el curso académico 2015-2016 han comenzado a ofertarse nuevas titulaciones universitarias acreditadas o las que han pasado la primera revisión de la ANECA-Agencia Nacional de Evaluación de la Calidad y Acreditación. Con el propósito de identificar si, en Cataluña, en el segundo despliegue del marco del EEES-Espacio Europeo de Educación Superior, se ha producido alguna nueva oferta de grados y/o de asignaturas específicos de comunicación corporativa y si éstos pertenecen –o no- al área de conocimiento de las relaciones públicas, los resultados del estudio revelan que únicamente se oferta un nuevo grado, en la Universidad Ramon Llull, que contemple el término comunicación corporativa en su denominación, siendo muy escasas las asignaturas que, desde distintos grados, lo incluyen.
Relaciones públicas, Responsabilidad Social Corporativa y Universidad. Análisis de la RSU del Centro Universitario de la Defensa de Zaragoza/Public Relations, Corporate Social Responsibility and University. Analysis of the RSU of the Centro Universitario
Authors: Hernández Corchete Sira
Published: August 2024

Desde el año 1998, la UNESCO viene planteando que las universidades deben asumir, dentro de la denominada “sociedad del conocimiento”, una mayor responsabilidad social como instituciones históricamente especializadas en la generación y la transmisión del saber. Además de cumplir con la legalidad vigente y las normas éticas generales, la Responsabilidad Social Universitaria (RSU), adaptación del concepto de Responsabilidad Social Corporativa (RSC) surgido en el ámbito empresarial, exige integrar en el plan de Relaciones Publicas estrategias, políticas y procedimientos que promuevan que el quehacer universitario esté cada vez más orientado a satisfacer las demandas de los públicos de interés respecto a la construcción de una sociedad más democrática, desarrollada, sostenible y solidaria.  El presente trabajo, que se inserta dentro del Proyecto de Investigación “Impacto económico y social del Centro Universitario de la Defensa de Zaragoza”, tiene como objetivo reflexionar acerca de la gestión estratégica de la RSU realizada por el Centro Universitario de la Defensa de Zaragoza.
Reseña: Responsabilidad Social en la Comunicación Digital Organizacional/Review: Social Responsibility in Organizational Digital Communication
Authors: Castillo Esparcia Antonio
Published: August 2024

La plena inserción en las lógicas comunicativas de las herramientas digitales ha motivado cambios profundos en los modelos y sistemas de la comunicación organizacional. El libro que nos ocupa es fiel reflejo de esta situación porque aborda en estudio de la comunicación digital en las organizaciones. En esta publicación, coordinada por las reconocidas investigadoras Rebeca Illiana Arévalo y María Antonieta Rebeil, se concitan diversos estudios sobre las manifestaciones de la comunicación organizacional realizadas por investigadores de México, Colombia y España.
Facebook como herramienta de Relaciones Públicas en las empresas: Información de negocios y de RSE en las empresas con mejor reputación a nivel mundial / Facebook as a Public Relations tool in companies: Information of business and the CSR in the world´s
Authors: Zeler Ileana , Capriotti Paul
Published: August 2024

Este artículo tiene como objetivo conocer los principales contenidos que difunden las empresas en Facebook, y los recursos de información que utilizan para ello. Los resultados de la investigación indican que la presencia de las empresas en Facebook está orientada a la difusión de contenidos de negocios, y muy pocas veces aprovechan la red social para promover la RSE, con poca interacción. Así, el uso de Facebook en las empresas se caracteriza por la difusión de información comercial, y no tanto de la Responsabilidad Social Empresaria (RSE), aplicando recursos poco interactivos. Por lo tanto, es necesario que las empresas revisen sus estrategias de comunicación y Relaciones Públicas en esta red social e integren todos los aspectos organizacionales, fomentando el diálogo y estimulando a los usuarios a involucrarse en las conversaciones.
Desafios para a atividade de relações públicas no mundo contemporâneo: pesquisa de opinião com profissionais do Estado de São Paulo/ Challenges for the public relations' activity in the contemporary world: opinion survey with professionals from the state
Authors: Pereira da Silva Marcelo , Trindade Ana Carolina , De Cássia Rossi Jéssica
Published: August 2024

A atividade de relações públicas carrega uma série de desafios no que tange ao ensino, aprendizagem e mercado. Por meio de revisão literária e pesquisa de opinião qualitativa, apresentamos alguns elementos históricos das relações públicas e as adversidades que a atividade atravessou em virtude de sua inserção autoritária no Brasil, lançando luz na falta de conexão entre o ensino ofertado pelas Instituições e as exigências do mercado. A partir deste artigo, percebemos que algumas necessidades do mercado de trabalho para as relações públicas decorrem da defasagem histórica entre o ensino e a aprendizagem e os problemas enfrentados pela falta de políticas afirmativas da profissão através dos órgãos de classe. Inferimos, assim, que tais aspectos exaltam os desafios e as oportunidades relacionados à docência das públicas, posto que em um país perpassado pela corrupção, a atividade ganha relevo na construção de um mundo mais justo por meio da verdade.
Pesquisa nacional dos cursos de Relações Públicas no Brasil: práticas dos coordenadores e docentes no processo ensino-aprendizagem/Country-wide survey of Public Relations undergraduate programs in Brazil: practices of coordinators and professors
Authors: Ferrari Maria Aparecida , Da Costa Piletti Grohs Ana Cristina
Published: August 2024

O objetivo da pesquisa foi identificar o perfil e as práticas dos coordenadores e docentes dos cursos de Relações Públicas em funcionamento no Brasil utilizando as categorias de IES públicas e privadas à luz da literatura especializada em ensino-aprendizagem e das novas diretrizes curriculares para o referido curso. O foco da pesquisa é inédito, uma vez que durante os levantamentos realizados não foram encontrados estudos similares no país. Dos 66 cursos de Relações Públicas no país, participaram 53 coordenadores e 255 docentes representando 80% do universo. Os resultados mostraram uma diminuição constante do número de cursos a partir de 2009. Observou-se que as práticas de ensino-aprendizagem utilizadas pelos docentes são excessivamente tradicionais para promover o protagonismo e a autonomia necessários para os profissionais no mundo atual.
Niveles de responsabilidad de los medios en sus relaciones con las minorías. Epilepsia y autismo/Levels of responsibility of the media in their relations with minorities. Epilepsy and autismo
Authors: Carreton-Ballester María Carmen , Lorenzo-Sola Francisco
Published: August 2024

Entre las funciones de los medios de comunicación, la función social parece que cada vez es más evidente en la práctica profesional. Sin embargo, en sus relaciones con colectivos minoritarios se puede hablar de ciertos niveles de responsabilidad a través de los cuáles se manifiesta la necesidad de abordar su vínculo desde las relaciones públicas. En este caso, presentamos a las minorías como público que no solo necesita de los medios para dar a conocer los issues que le afectan y llegar a la sociedad para cambiar actitudes y lograr conductas en beneficio de sus demandas; sino que, además, requieren de estas acciones afirmativas y conductas responsables en la formación de esa opinión pública y evitar nuevos conflictos. De ahí la necesaria relación basada en una conducta simétrica bidireccional (Grunig y Hunt, 2000) entre minorías y medios de comunicación. Las noticias sobre epilepsia y autismo en el período analizado muestran la falta de conocimiento que los medios tienen de estos colectivos para cumplir con esa parte de responsabilidad que tienen para la sociedad.Palabras clave: Autismo, Epilepsia, Medios de comunicación, Minorías, Relaciones Públicas, Responsabilidad Social. Abstract Among the functions of the media, the social function seems to be increasingly evident in professional practice. However, in its relations with minority groups we can speak of certain levels of responsibility through which the need to address its link from public relations is manifested. In this case, we present the minorities as a public that not only needs the means to publicize the issues that affect them and reach society to change attitudes and achieve behaviors to benefit their demands; but, in addition, they require these affirmative actions and responsible behaviors in the formation of that public opinion and avoid new conflicts. Hence the necessary relationship based on a bidirectional symmetric behavior (Grunig and Hunt, 2000) between minorities and the media. The news about epilepsy and autism in the period analyzed shows the lack of knowledge that the media have of these groups to fulfill that part of responsibility they have for society. Keywords: Autism, Epilepsy, Media, Minorities, Public Relations, Social Responsibility
Presentación/Presentation
Authors: ALMANSA-MARTÍNEZ ANA
Published: August 2024

Estamos ante un número muy variado en cuanto a las temáticas tratadas. Siempre con una visión global de las relaciones públicas. Precisamente, ese ha sido el nombre elegido para el número, por reflejar la generalidad y, a la vez, la especificidad, de la disciplina.Un número que ya está a la disposición de todos los lectores, investigadores, docentes y personas interesadas en las relaciones públicas. A disposición de quien lo desee de forma gratuita y en Creative Commons. Porque la revista nació para ser una plataforma en la que difundir la investigación en relaciones públicas y hoy este sigue siendo su mayor compromiso.En este sentido, la revista está de enhorabuena, ya que recientemente se ha convertido en la primera revista en su especialidad en el Ranking de revistas REDIB.  De esta manera, la revista es referente en la investigación en Comunicación Organizacional y Relaciones Públicas en América Latina. Gracias a todos los autores y lectores que lo han hecho posible.¡Buena lectura de este número!
A privatização da ética no Brasil: posicionamento da Petrobrás no canal do Youtube / The ethic’s privatization in Brazil: positioning of Petrobrás in the Youtube channel
Authors: Cabral Raquel , Andrelo Roseane , Granato Mariany Schievano
Published: August 2024

RESUMO Neste artigo investiga-se os produtos de comunicação com conteúdo relacionado à ética, nas tecnologias digitais de comunicação e informação, centralizadas no canal do Youtube da estatal petrolífera brasileira Petrobrás, após as denúncias de desvio de dinheiro público comprovadas pela Polícia Federal por meio da operação intitulada “Lava Jato”. Buscou-se analisar os tipos de conexão gerados a partir deste conteúdo: associativos ou emergentes (RECUERO, 2012). A situação problemática reside em como as empresas lidam com a questão da ética na pós-modernidade, principalmente quando existem casos de corrupção comprovada e necessitam recuperar a confiança da opinião pública. Presume-se que estas empresas têm começado um movimento de privatização da ética, lançando departamentos de conduta ética para provar integridade, principalmente, frente à opinião pública, bem como utilizando discursos enviesados, como demonstrado na análise de conteúdo em quatro vídeos disponibilizados pela Petrobrás em seu canal do Youtube. Para a fundamentação teórica, conceitos como pós-modernidade, informação pública, relações públicas, ética e capital social são abordados. Palavras chave: ética; Petrobrás; tecnologias digitais de comunicação e informação; capital social; relações públicas.  ABSTRACT This article investigates the construction of content related to ethics, in digital technologies of communication and information, centralized in the Youtube channel of the Brazilian state-owned oil company Petrobrás, after the denunciations of public money diversion verified by the Federal Police through the operation titled " Car wash". We attempted to analyze the types of connections generated from this content: associative or emergent (RECUERO, 2012). The problematic situation lies in how companies deal with the issue of ethics in postmodernity, especially when there are cases of proven corruption and need to restore public confidence. It is presumed that these companies have begun a privatization movement of ethics, launching departments of ethical conduct to prove integrity, especially in the face of public opinion, as well as using biased speeches, as demonstrated in the content analysis in four videos made available by Petrobrás in your Youtube channel. For the theoretical foundation, concepts such as postmodernity, public information, public relations, ethics and social capital are approached Keywords :ethics; Petrobrás; digital technologies of information and communication; social capital; public relations.
Comunicação estratégica e estratégias de comunicação em contexto midiatizado: estudo exploratório com empresa da cidade de Bauru (Brasil) / Strategic communication and communication strategies in a mediatized context:an exploratory study in Bauro (Brazil)
Authors: Bueno Daniele Aparecida , Porem Maria Eugênia
Published: August 2024

Frente ao cenário midiatizado, as organizações são desafiadas a repensar sobre o modo como desenvolvem seus processos, a exemplo das estratégias de comunicação, a fim de superar modelos de cunho meramente instrumental. Parte-se da problemática de que as estratégias de comunicação das organizações deveriam considerar a comunicação estratégica como instância norteadora de suas ações, aqui entendida como proposta integradora que pode orientar as ações organizacionais, de modo a interligar a organização ao contexto social, político e cultural midiatizado. Reconhece-se que estratégias de comunicação alheias ao contexto se desmembram em ações puramente mercadológicas e pontuais, não levando em consideração os diversos públicos que estão em interação e se vinculam às organizações. Deste modo, este trabalho, de caráter exploratório, tem como objetivo identificar as estratégias de comunicação em micro, pequena e média empresa do setor Alimentação Fora do Lar da cidade de Bauru/SP-Brasil, buscando reconhecer se essas ações são desenvolvidas sob uma lógica meramente mecanicista ou se possibilitam uma perspectiva norteadora da comunicação estratégica. Como resultados, verificou-se que prevalecem, nessas organizações, estratégias de comunicação trabalhadas primordialmente no ambiente digital sob um viés funcionalista. Palavras-chave: Estratégias de comunicação, comunicação estratégica, organizações, contexto midiatizado, micro, pequenas e médias empresas Abstract In view of the mediatized scenario, organizations are challenged to rethink how they develop their processes, such as communication strategies, in order to overcome merely instrumental models. It parts from the problem that the communication strategies of organizations should consider strategic communication as the guiding principle of their actions, here understood as an integrative proposal that can guide the organizational actions, in order to interconnect the organization to the social, political and cultural context mediated. It is recognized that non-contextual communication strategies are disaggregated into purely market-based and punctual actions and do not take into account the diverse publics that are in interaction and are linked to the organizations. In this way, this exploratory work aims to identify communication strategies in micro, small and medium-sized companies in the Food Service segment in Bauru city (Brazil), seeking to recognize if these actions are developed under a purely mechanistic logic or if they allow a guiding perspective of strategic communication. As results, it was verified that, in these organizations, communication strategies worked mainly in the digital environment under a functionalist bias prevail. Keywords: Communication strategies, strategic communication, organizations, mediatized context, micro, small and medium companies
Comparison of deuterium metabolic imaging measurements in human subjects at 7T following [2H2] glucose and [2H7] glucose ingestion
Authors: Cocking Daniel , Damion Robin , Simpson Elizabeth , Greenhaff Paul , Dexter Louise , Auer Dorothee , Bowtell Richard
Published: August 2024

We compared the use of DMI following D2-glucose and D7-glucose ingestion in the investigation of brain metabolism in vivo. Multiple CSI measurements were acquired from five participants over ~180 minutes at 7T following ingestion of each labelled compound. D7-glucose produced significantly larger signals allowing improved mapping of the signals from labelled metabolites. Calculated time-courses of the changes in metabolite concentration in different brain tissues show significantly larger rates of increase of HDO and Glx in all tissues for D7- versus D2­-glucose (e.g. in GM HDO rate of increase for D7/D2 = 0.208±0.004/0.051±0.001 mM/min and Glx rate for D7/D2 = 0.059±0.003/0.029±0.001 mM/min).
Imaging choline phospholipid biosynthesis in gliomas using deuterium magnetic resonance spectroscopy
Authors: Taglang Celine , Batsios Georgios , Gillespie Anne-Marie , Viswanath Pavithra
Published: August 2024

Aberrant choline phospholipid biosynthesis is a metabolic hallmark of cancer. Choline kinase α (CKα) is the key enzyme in this pathway. Non-invasive methods of imaging CKα have the potential to report on tumor proliferation. Here, using a combination of RNA interference and doxycycline-inducible gene silencing systems, we show that deuterium magnetic resonance spectroscopy following administration of [2H9]-choline non-invasively reports on CKα activity in patient-derived glioma cells and intracranial tumors. Importantly, [2H9]-choline provides an early readout of response to chemotherapy in mice bearing intracranial gliomas. Our studies identify a novel agent for metabolic imaging of gliomas and their response to therapy.
Determining the minimum injected [2,3-2H2]fumarate concentration required for deuterium metabolic imaging of tumor cell death post-treatment
Authors: Hesse Friederike , Bulat Flaviu , Kreis Felix , Brindle Kevin
Published: August 2024

2H MRI measurements of labeled malate production following intravenous injection of 2H-labeled fumarate (1 g/kg) have been used to detect tumor cell death post-treatment in pre-clinical tumor models. We show here that much lower concentrations of 2H-labeled fumarate (0.1, 0.3 and 0.5 g/kg) can still generate a significant increase in malate concentration post-treatment, which should facilitate clinical translation. Mice were implanted subcutaneously with a triple-negative breast cancer model (MDA-MB-231) and treated with three different concentrations of a TRAIL-R2 agonist (MEDI3039). The different degrees of cell death obtained were linearly correlated with the malate/fumarate signal ratio and the absolute malate concentration.
Neuroinflammation and amyloid deposition in the progression of mixed Alzheimer and vascular dementia
Authors: Ying Chunwei , Kang Peter , Binkley Michael , Ford Andria , Chen Yasheng , Hassenstab Jason , Wang Qing , Strain Jeremy , Morris John , Lee Jin-Moo , Benzinger Tammie , An Hongyu
Published: August 2024

Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) pathologies commonly coexist in community-dwelling elderly. It is not discernible whether neuroinflammation and amyloid beta (Aβ) deposition are distinct or entangled pathophysiological mechanisms in patients with mixed AD and VCID pathologies. In this study, we found that neuroinflammation (measured by 11C-PK11195 uptake) but not Aβ deposition (measured by 11C-PiB binding), contributes to white matter hyperintensities baseline volume and progression. Both neuroinflammation and Aβ deposition independently contribute to cognitive impairment progression. Neuroinflammation and Aβ deposition represent two distinct pathophysiological pathways in elderly participants with mixed AD and VCID pathologies.
Disruption to normal excitatory and inhibitory function within the medial prefrontal cortex in patients with IBD
Authors: Wang Jun , Liu Guangyao , Ai Kai , Zhang Pengfei , Huang Wenjing , Zhang Jing
Published: August 2024

The etiology of IBD complicated with anxiety, depression and other psychological comorbidities is still unclear. The purpose of this study was to quantify neurotransmitter (GABA and Glx) in the medial prefrontal cortex (mPFC) of IBD patients with MEGA-PRESS spectroscopy and explore its relationship with clinical scores. We found that mPFC GABA+ and Glx concentration were significantly decreased in IBD patients and were associated with abdominal pain and depressive symptoms separately, suggesting psychological comorbidities in IBD patients were related to mPFC neurotransmitter dysregulation. It provides a new explanation for the neuropsychological mechanism of IBD in the development of the disease.
Quantifying Cervical Spinal Cord Pathology of Multiple Sclerosis Patients Using Advanced MRI
Authors: Hatipoglu Osman , Charidimos Tsagkas , Ocampo-Pineda Mario , Melie-Garcia Lester , Weigel Matthias , Lu Po-Jui , Barakovic Muhamed , Cohen-Adad Julien , Kappos Ludwig , Kuhle Jens , Granziera Cristina
Published: August 2024

The utility of advanced quantitative MRI for assessment of spinal cord tissue damage in multiple sclerosis has not yet been established. In this work, we used T1-mapping as well as quantitative magnetization transfer saturation and echo-planar imaging to quantify the extent of pathologic changes in the cervical cord of multiple sclerosis patients. Our results point to extensive demyelination and axonal loss both in the normal-appearing and lesional cervical cord, as well as to and chronic inflammation of cSCWM lesions in secondary progressive multiple sclerosis. Hence, quantitative spinal cord MRI may provide valuable information about the pathologic substrate of this disease.
Multimodal 9.4T MRI and Near-Infrared Spectroscopy shows reduced perfusion and abnormal oxidative metabolism in the EAE mouse model of MS
Authors: Hashem Mada , Hamilton A. , Dunn Jeff
Published: August 2024

While multiple sclerosis (MS) is typically considered a white matter disease, there is prominent evidence that gray matter pathology, such as hypoxia, disruptions in metabolic rate and mitochondrial dysfunction are involved as well. We are applying a novel multimodal technique combining near-infrared spectroscopy and high-field MRI to study the mitochondrial status as well as oxygen delivery and consumption in the cortex of the EAE mouse model of MS. Reduced perfusion, and consequent hypoxia, with abnormal mitochondrial regulation and no change in consumption rate were found in EAE mice. Hypoxia and mitochondrial damage are likely to exacerbate the pathology in MS.
Total and regional brain volumes in fetuses with congenital heart disease
Authors: Cromb Daniel , Uus Alena , Van Poppel Milou , Steinweg Johannes , Bonthrone Alexandra , Maggioni Alessandra , Cawley Paul , Kyriakopoulou Vanessa , Matthew Jacqueline , Price Anthony , Edwards A , Deprez Maria , Hajnal Joseph , Lloyd David , Pushparajah Kuberan , Simpson John , Rutherford Mary , Counsell Serena
Published: August 2024

Total and regional brain volumes, derived from automatically segmented, motion-corrected, 3D fetal brain MR images were obtained in 45 healthy fetuses and 305 fetuses with isolated congenital heart disease (CHD) in the third trimester. Total brain tissue, cortical and deep grey matter, and white matter volumes are significantly lower in fetuses with CHD where cerebral oxygenation and substrate delivery are likely to be reduced. Brain volumes appear normal in fetuses with CHD but an otherwise expected normal cerebral oxygenation.
Causal evidence for cerebello-limbic-striatal circuit dynamics supporting depression
Authors: Zheng Ruiping , Cheng Jingliang , Zhang Yong
Published: August 2024

The striatum is known to be impaired in MDD patients. Abnormal structure or function of the striatum may disturb the top-down regulation of negative emotions among persons more vulnerable to developing depressive state, especially adolescent. Here, we investigated (1) voxel-wise FC between the striatal nucleus and the whole brain; (2) region of interest wise effective connectivity using DCM analysis, according to the between-group differences in FC of the striatal nucleus. We found decreased FC in cerebello-limbic-striatal circuit, and further DCM analysis showed the dysregulation of vrPUT nucleus disturb the top-down regulation of cerebello-limbic-striatal circuit during reward processing in adolescent MDD.
Comparing vascular morphology and hemodynamics in patients with Vein of Galen Malformations using intracranial 4D flow MRI
Authors: Stout Jeffrey , Swanson Julie , See Alfred , Rangwala Shivani , Orbach Darren
Published: August 2024

Vein of Galen Malformation is the most common congenital cerebrovascular malformation and patients have variable mortality risk and cognitive outcomes. Tools are needed to guide treatment decisions, so we investigated the hemodynamic underpinnings of a morphological metric used for clinical prognostication. We used 4D flow MRI to quantify flow through the venous sinus that drains the malformation, and compared this to the maximum mediolateral diameter of the same sinus. A significant positive correlation between flow and diameter was observed when controlling for prior embolization; this finding motivates continued efforts to develop hemodynamic metrics of disease severity and treatment progress.
Motion-Resolved Self-Gated Free-Breathing 3D Liver PDFF and R2* Mapping using Phase-Preserving Beamforming and Non-Rigid Motion Compensation
Authors: Shih Shu-Fu , Kafali Sevgi , Calkins Kara , Wu Holden
Published: August 2024

3D self-navigated multi-echo stack-of-radial Dixon sequence has been used to quantify fat and R2* with free-breathing acquisitions. To compensate motion, motion-resolved compressed sensing (CS) uses self-navigation for data binning, and applies sparsity constraint along the dimension of motion states. However, this approach does not explicitly model non-rigid motion in the liver. In addition to artifacts caused by respiratory motion, hardware imperfection such as gradient nonlinearity can lead to artifacts and affect the image quality. In this work, use a phase-preserving beamforming-based coil sensitivity estimation method and non-rigid motion compensation in a CS model to improve free-breathing PDFF and R2* quantification.
Respiratory-motion-corrected simultaneous 3D T1, T2, and fat-fraction mapping at 0.55T, for comprehensive characterization of liver tissue
Authors: Tripp Donovan , Kunze Karl , Crabb Michael , Neji Radhouene , Prieto Claudia , Botnar René
Published: August 2024

Through T1, T2, and fat fraction mapping, MRI is a formidable tool for the comprehensive assessment of liver health, but has been held back by slow, 2D, single-parameter mapping sequences. We propose a novel respiratory-motion-corrected framework to acquire all three of these maps from a single 6.5-minute scan, on the latest generation of 0.55T scanner. The resulting maps are 3D, with 3 mm isotropic resolution, and co-registered, making them suitable for multiparametric assessment of tissue health. Liver joint T1, T2, and fat fraction maps are in good agreement with reference values and first in-vivo scans provide promising image quality.
Free-Breathing Liver Iron Quantification Using 3D Stack-of-Radial GRE Dixon MRI at Two Field Strengths: A Preliminary Study
Authors: Zhong Xiaodong , Kannengiesser Stephan , Leon Pedro , Deshpande Vibhas , Yokoo Takeshi
Published: August 2024

This study compared free-breathing stack-of-radial and breath-hold Cartesian multi-echo GRE MRI for liver iron quantification at 1.5T and 3T to the reference standard R2-based liver iron concentration (LIC) at 1.5T (FerriScan), in patients at risk for liver iron overload. Agreement was observed for liver iron concentration measured by free-breathing 3D stack-of-radial GRE MRI compared the reference standard R2-based LIC, as well as breath-hold 3D Cartesian GRE MRI. With further validation in larger number of iron-overloaded subjects, 3D stack-of-radial GRE MRI may allow free-breathing R2* and LIC mapping at both 1.5T and 3T.
Evaluation of liver fibrosis using histogram analysis with diffusion kurtosis imaging and stretched-exponential diffusion model
Authors: Fan Fengxian , Jiang Yanli , Zou Jie , Yang Pin , Zhang Jing
Published: August 2024

This study aims to evaluate the potential role of histogram analysis of diffusion kurtosis imaging (DKI) and stretched exponential model (SEM) for preoperative prediction of liver fibrosis and inflammation. Histogram metrics were extracted from mean diffusion (MD), mean kurtosis (MK), distributed diffusion coefficient (DDC) and intravoxel heterogeneity index (α). The histogram metrics of MD, DDC and α demonstrate significant correlation with inflammation, the histogram metrics of MD and DDC were significantly different between S0-1 and ≥S2. Histogram analysis of DKI and SEM may be potentially useful for evaluating heterogeneity of liver.
Comparing and combining MRI-ECV, DKI, and DWI for the staging of liver fibrosis in chronic hepatitis B Patients: A multiparametric model
Authors: Wei Zhou , Liu* Yupin , Li Xiaohuan , Chen Zhiyuan , Grimm Robert , Wu Yunzhu
Published: August 2024

Liver fibrosis (LF) is a dynamic, reversible process which can result in liver failure. Diagnosis and monitoring of LF are clinically important. This study was to evaluate the diagnostic capability of the model based on multiparametric MRI in identifying significant LF in patients with chronic hepatitis B (CHB). The predictive model based on multiparametric MRI further could improve diagnostic accuracy and serve for identifying significant LF in CHB patients, also provide a reliable basis for clinical diagnosis and treatment.
What if every voxel was measured with a different diffusion protocol?
Authors: Coelho Santiago , Lemberskiy Gregory , Zhu Ante , Abad Nastaren , Foo Thomas , Fieremans Els , Novikov Dmitry
Published: August 2024

A naive answer to this question is to loop over all voxels re-do the training and apply machine learning estimators of your favorite model. This is grossly computationally inefficient. We propose a matrix pseudoinversion-based method that can estimate nonlinear biophysical model parameters from a large set of voxels with independent acquisition protocols in a few minutes. Our framework can be tailored to any convolution-based model. Furthermore, the protocols are not required to have shells and there are no limits to the protocol differences among voxels. This method is readily extendable for simultaneously varying diffusion times, B-tensor shapes, TE, etc.
Measurement of tumor heterogeneity with habitats in breast cancer and its application in molecular subtype discrimination
Authors: Xu Run , Li Guanwu , YU Dan , Dai Yongming , Liang Xinyue
Published: August 2024

In this work, multiparametric MRI was applied to reconstruct spatial habitats and validate the association with the molecular subtypes of breast cancer. By combining perfusion and diffusion characteristics, three habitats were constructed and assigned: hypervascular habitat, hypovascular cellular habitat, and nonviable habitat. In triple-negative breast cancer (TNBC), the volume fraction is lower for hypervascular habitat and higher for nonviable habitat, with respect to non-TNBC.
Confidence Maps for Reliable Proton Density Fat-Fraction and R2* Estimation
Authors: Tamada Daiki , Van der Heijden Rianne , Hernando Diego , Reeder Scott
Published: August 2024

In this work we develop a confidence map algorithm to identify reliable estimates of PDFF and R2* for CSE-MRI in the liver. Reliability of estimates is evaluated based on a normalized root-mean-square-error (NRMSE) between measured and model signals. Threshold values of the NRMSE are determined by using the Cramér–Rao Lower Bound. Monte-Carlo simulations and clinical CSE-MRI successfully validate the proposed method.
Fibromyalgia associates with pain-promoting and inhibitory functional connectivity of the default mode network in psoriatic arthritis.
Authors: Stefanov Kristian , Sunzini Flavia , Al-Wasity Salim , Harte Steven , Harris Richard , Clauw Daniel , Waiter Gordon , Cavanagh Jonathan , Basu Neil
Published: August 2024

Patients with the musculoskeletal disorder psoriatic arthritis improve their inflammation with current treatments but still experience pain. Previous neuroimaging findings have identified functional connectivity of the resting-state default mode network and we explored how such features associate with nociplastic pain using both agonistic and selective approaches. We observed increased connectivity between the default mode network and regions of the brain related to both increased pain intensity and decreased pain inhibition. The implications of such findings shift the focus onto targeting central pain pathways in people with psoriatic arthritis.
Towards the understanding of the the role of Functional strength markers in Cartilage-Bone Cross Talk: a PET/MRI study in isolated PFJOA patients
Authors: Bhattacharjee Rupsa , Hammond Eric , Roach Koren , Bahroos Emma , Souza Richard , Majumdar Sharmila , Pedoia Valentina
Published: August 2024

In this exploratory study, we investigated standardized-uptake-values(SUV) from simultaneous bilateral PET-MRI, and individual joint loading in knees cross-sectionally in patients with isolated PFJOA. Additionally, to discover regions of colocalized changes in bone-cartilage interactions, we explored SUV interactions with cartilage biomarker T1rho relaxation values from high-resolution bilateral axial MAPSS. Strong negative correlations were between knee normalized isometric strength vs. maximum SUV in the lateral patella and medial trochlea, suggest higher degree of ongoing bone-remodelling combined with decreased knee flexion and extention strength. The existance of parallel higher trochlear bone remodelling and cartilage loss (disease progression) or vice-versa was also noted.
Adaptive Magnetic Resonance
Authors: Tal Assaf , Beracha Inbal , Seginer Amir
Published: August 2024

We present a completely general framework for adaptively changing the radiofrequency pulses and delays in real time in response to incoming data from the subject within the scanner. This "personalized-radiology" framework is shown to increase the precision of T2 estimation for n-acetyl-aspartate in-vivo by a factor of 1.7, and accelerate its acquisition 2.5-fold.
Efficient iT2prep-BOOST for simultaneous contrast-free 3D aortic lumen and vessel wall imaging for the assessment of thoracic aortopathy
Authors: Fotaki Anastasia , Munoz Camila , Hua Alina , Kunze Karl , Neji Radhouene , Pushparajah Kuberan , Botnar Rene , Prieto Claudia
Published: August 2024

Bright- and black-blood MRI sequences are clinically acquired sequentially, for aortic lumen and vessel wall imaging respectively, in patients with thoracic aortic disease. A novel, free-breathing, 3D sequence (iT2prep-BOOST) is proposed for contrast-free simultaneous depiction of lumen and vessel wall. We clinically validated the iT2prep-BOOST in a cohort of 25 patients with thoracic aortic disease against the conventional bright-blood T2-prep bSSFP sequence and black-blood 2D HASTE. Quantitative and qualitative image quality assessment demonstrated that iT2Prep-BOOST enabled time-efficient, bright- and black-blood aortic imaging, with improved image quality compared to conventional approaches, and comparable measurements for aortic wall and lumen dimensions.
Development of a Pulse Sequence with Alternating Excitation for Respiratory-Sorted B1+ and B0 Field Mapping in 23Na Human Torso MRI
Authors: Felz Jana , Kratzer Fabian , Nagel Armin , Bachert Peter , Ladd Mark , Platt Tanja
Published: August 2024

23Na MRI is a promising imaging method, but suffers from lower SNR, hence from longer acquisition times and lower image resolution than 1H MRI. Especially in the torso, motion and magnetic field inhomogeneities impede quantitative analysis of 23Na concentrations. To tackle this, a new pulse sequence is presented that yields self-gated respiratory-sorted B1+ and B0 maps from a single measurement. B1+ mapping with the new sequence is less prone to motion artefacts, since k-space projections of two flip angles are acquired in an interleaved manner. This reduces the influence of varying respiration, which can lead to artefacts in conventional mapping.
Advanced Spatial-Spectral Pulse Design for Metabolite Specific Filtered CEST in the Human Heart
Authors: Ayala Cindy , Luo Huiwen , Godines Kevin , Grissom William , Vandsburger Moriel
Published: August 2024

Chemical Exchange Saturation Transfer (CEST) MRI has been used to probe metabolism via total creatine contrast using conventional contrast generation with Gaussian saturation. We developed a spatial-spectral (SPSP) saturation pulsed CEST protocol to separate the contrast generated by metabolic subcomponents creatine and phosphocreatine (PCr) in phantoms and the human heart (n=10). Phantom studies revealed uniform CEST contrast for creatine and PCr following saturation with Gaussian pulses, and selective PCr contrast following saturation with SPSP pulses. Human studies revealed both enhanced B1-uniformity and selective PCr contrast with SPSP saturation, enabling quantitation of the PCr/total creatine ratio in the myocardium.
Ultrashort Echo Time Single Point Dixon Using 3D Phase Modeling
Authors: Newbury Nathan , Sedaghat Sam , Athertya Jiyo , Carl Michael , Du Jiang , Jang Hyungseok
Published: August 2024

Fat signals can obscure morphological structures and influence quantitative parameter mapping in ultrashort echo time (UTE) musculoskeletal MRI. However, conventional fat suppression methods have challenges in UTE imaging of short T2 species. For example, the chemical-shift based fat saturation can significantly attenuate short T2 signals with broad spectra, and water excitation with long composite pulses may yield a long minimum echo time (TE). Alternatively, the feasibility of single-point Dixon (1p-Dixon) has been demonstrated for UTE imaging. In this study, we investigate the feasibility of 1p-Dixon based on the 3D phase modeling approach, which achieves fat suppression without additional data acquisition.
Self-supervised pretraining and network ensembling for spatial mapping of treatment-effect in recurrent GBM with physiologic MRI
Authors: Ellison Jacob , Tran Nate , Hanna Rany , Cluceru Julia , Phillips Joanna , Molinaro Annette , Pedoia Valentina , Luks Tracy , Shai Anny , Nair Devika , Villanueva-Meyer Javier , Berger Mitchel , Hervey-Jumper Shawn , Aghi Manish , Chang Susan , Lupo Janine
Published: August 2024

Prior characterization of treatment-effect and tumor recurrence using deep learning approaches have not optimized for spatial classification within a single lesion, which could improve surgical planning and treatment. 10mm patches of pre-surgical anatomical and physiological images surrounding the locations of histopathologically-confirmed tissue samples were used to train our models. Including physiological images, pretraining on unlabeled data in an autoencoding task, and training with an alternative cross-validation approach that enabled many networks to be ensembled, we achieved an ensembled test AUROC of 0.814 and generated spatial maps of tumor probability and model uncertainty. Performance decreased when removing any of these components.