bluuebunny/crossref_metadata_2025 huggingface dataset:
Sakhalin Island in the Soviet and Russian Audiovisual Text
Authors: Lavrenova Olga
Published: January 2025

Sakhalin is the largest island of the Russian Empire, the USSR, and now of modern Russia. This is why its audiovisual representations encompass various aspects of life, centering on different social problems and combining descriptions and depictions of natural features. The comprehension of this region began with Anton Chekhov, who visited in the late 19th century. Through his own observations, Chekhov presented a unique perspective on the social problems of Sakhalin, which then served as a place of exile. He also brought a collection of photographs (works by Innokenty Pavlovsky among them), depicting everyday scenes of convicts, including their shackling. The visual representation of the local indigenous peoples’ lives and traditions also dates back to the 19th century.
During the Soviet era, Sakhalin saw the production of highly skilled documentary films showcasing the island’s development, natural resources, and tension on the border; it also became the setting for several feature films. Noteworthy among the feature films of the late Soviet period is Karen Gevorkian’s adaptation of the novel, Spotted Dog Running at the Edge of the Sea, by Chingiz Aitmatov. It focuses on the small (about 4,500 individuals) Nivkh people, incorporating documentary footage of their lives into the narrative.
In post-perestroika Russia, the focus shifted in feature films, including those about Sakhalin. Documentaries about the island experienced a resurgence as the state recognized its strategic importance. Numerous professional films were made, highlighting Sakhalin’s natural wealth and the lives of its residents on the edge of the world. And in the early 2000s, a new genre emerged: “people’s videos” created by islanders and travel bloggers. Although lacking a traditional plot, these films simply describe the authors personal encounters with the geographical reality of the island. However, both Soviet and post-Soviet documentaries occasionally revisit the theme of hard labor, as well as the persisting topic of challenges faced by small ethnic groups.
Factors Influencing Depression among the Elderly in Island Regions
Authors: Choi Jeong-Min , Park Ji-Hwan
Published: January 2025

The purpose of this study is to identify factors influencing depression among elderly people in island regions. To achieve this research objective, the study used raw data from the “Community Health Survey 2021” conducted by the Korea Disease Control and Prevention Agency. Its actual analysis was based on raw data from the “Community Health Survey 2021”, targeting 450 elderly people aged 65 or older residing in Sinan-gun, Jeollanam-do, surveyed by Sinan-gun Public Health Center. In addition, a regression analysis was performed using SPSS version 29.0 to test the research hypotheses. The results of verifying the research hypotheses showed that gender, economic activity, pain, subjective health, and subjective stress would have significant effects on depression among elderly people in island regions. Based on these research findings, various practical and policy recommendations were presented to help manage depression among the elderly in island regions.
An Azomethine Derivative, 1-(4-nitrophenyl)-N-phenylmethanimine (BCS2) Ameliorated 7,12-dimethylbenz(a)anthracene-induced Mammary Carcinoma through Nrf2-Keap1-HO-1 Pathway
Authors: Acharya Reetuparna , Deb Pran Kishore , Pattanayak Shakti Prasad
Published: January 2025

Aims:

The aim of this study is the evaluation of an Azomethine derivative, BCS2, for
its antioxidant and anti-tumor activities against mammary carcinoma through the Nrf2-
Keap1-HO-1 pathway.

Background:

The global prevalence of breast cancer is rising at an alarming rate. The facilitation
of abnormal cell proliferation in mammary carcinoma occurs due to the disruption of signaling
pathways that balance pro- and antioxidant status, thereby producing oxidative stress that
disrupts genomic stability. Therefore, introducing a potent antioxidant molecule with antitumor
activity is of paramount importance for treating breast cancer.

Objective:

Synthesis, characterization, and in-vitro, in-vivo, and in-silico evaluation of an
Azomethine derivative, BCS2, for its antioxidant and anti-tumor activities against chemical carcinogen-
induced mammary carcinogenesis in Sprague-Dawley rats.

Methods:

An azomethine derivative, 1-(4-nitrophenyl)-N-phenylmethanimine (BCS2), was synthesized
and characterized based on its spectral data. The cytotoxic potential was observed on
breast cancer cells, MCF-7, MDA-MB-231, and MDA-MB-468. The in vivo chemotherapeutic
potential of BCS2 was established on 7,12-dimethylbenz(a)anthracene (DMBA) induced breast
cancer in Sprague-Dawley (SD) rats. The effect of BCS2 on kelch-like ECH-associated protein-
1 (Keap1), Nrf2, heme oxygenase-1 (HO-1), mitogen-activated protein kinase (MAPK),
and nuclear factor kappa-light-chain-enhancer of activated-B (NF-κB) was evaluated through
ELISA and qPCR techniques. Furthermore, the binding potential and stability of BCS2 with
Keap-1, HO-1, and MAPK were predicted using in silico molecular docking and dynamics
studies. Additionally, drug-likeness properties of BCS2 were evaluated using in silico ADMET
tools.

Results:

BCS2 showed remarkable cytotoxic activity on MCF-7 cells followed by MDA-MB-
231 and MDA-MB-468 cells having an IC50 of 2.368μM, 4.843μM and 6.472μM respectively,
without affecting normal breast cells, MCF-10A. In the DMBA-induced animal model, BCS2
showed potent antitumor potential and showed protective action on endogenous-enzymatic
and non-enzymatic antioxidants in cancer-bearing animals. Marked improvement in cellular architecture
and ultrastructure of breast/tumor tissues excised from experimental animals was noted
through histopathological and field emission scanning electron microscopy (FESEM) analyses.
Significant upregulation of antioxidant proteins, Keap1 and HO-1, and downregulation of inflammatory
proteins, MAPK, and NF-κB was observed after BCS2 treatment. The in silico computational
studies predicted the potent binding of BCS2 with the active pockets of Keap1,
HO-1, and MAPK proteins that validated the biological findings.

Conclusion:

The study revealed BCS2's potent antioxidant and antitumor potential against mammary
carcinoma through the Nrf2-Keap1-HO-1 signaling pathway.
Decoding Epilepsy: Prickle2 and Multifaceted Molecular Pathway Connections
Authors: Liu Yuhang , Peng Fan , Shu Jie , Li Xiaolan , Yuan Chengfu
Published: January 2025

Background:

The Prickle2 (Pk2) gene shows promising potential in uncovering the underlying
causes of epilepsy, a neurological disorder that is currently not well understood. This paper utilizes the online
tool PubMed to gather and condense information on the involvement of PCP channels and the associated roles
of PCP pathway molecules in the onset of epilepsy. These findings are significant for advancing epilepsy
treatment. Additionally, the paper discusses future directions for clinical trials and outlines potential therapeutic
targets.

Methods:

This review systematically analyzes the biological functions and mechanisms of the Prickle2 gene
in epilepsy. Studies were retrieved from PubMed using keywords such as "Prickle2", "epilepsy", and "PCP
pathway", focusing on research published between 2000 and 2023 in English. Inclusion criteria included original
studies and reviews on Prickle2's role in epilepsy. Studies unrelated to these topics or lacking sufficient
data were excluded. Key data on Prickle2's functions and its link to epilepsy were extracted, and findings were
summarized after a quality assessment of the literature.

Results:

Although there are currently conflicting results regarding the possibility that Prickle2 may cause epilepsy
in different organisms, we believe that as more cases involving Prickle2 mutations are reported and
more related animal experiments are conducted, the findings will become clearer.

Conclusion:

Due to the biological functions and mechanisms associated with the Prickle2 protein, it may
serve as a useful biomarker or potential therapeutic target for epilepsy treatment.
Fenofibrate Inhibits LPS and Zymosan-induced Inflammatory Responses through Sonic Hedgehog in IMG Cells
Authors: Wang Yu-Wen , Huang Bor-Ren , Lu Dah-Yuu , Chen Jin-Wun , Charoensaensuk Vichuda , Yang Liang-Yo , Lai Sheng-Wei , Tsai Cheng-Fang , Yeh Wei-Lan
Published: January 2025

Background:

Neuroinflammatory responses are strongly associated with the pathogenesis of progressive neurodegenerative conditions and mood disorders.
Modulating microglial activation is a potential strategy for developing protective treatments for central nervous system (CNS)-related diseases.
Fibrates, widely used in clinical practice as cholesterol-lowering medications, exhibit numerous biological activities, such as anticancer and antiinflammatory
activities. However, the mechanisms underlying their beneficial effects on the CNS remain unclear.

Objective:

This study investigated the mechanisms through which fibrates influence inflammatory and anti-inflammatory homeostasis in microglial cells.

Methods:

Cell viability assay, nitric oxide measurement, Western blot analysis,, real-time PCR, and cell transfection were used in this study.

Results:

Fenofibrate, a well-known fibrate, reduced the production of nitric oxide and interleukin-6 and the expression of inducible nitric oxide synthase
and cyclooxygenase-2 in microglial cells. It also inhibited the expression of various proinflammatory cytokines and chemokines, including tumor
necrosis factor-ɑ and interleukin-1β, and chemokine (C-C) motif ligand 2 and chemokine (C-X-C motif) ligand 10. Notably, treatment of
fenofibrate dramatically activated the sonic hedgehog (SHH) and sirtuin-1 (SIRT1). Furthermore, the inhibition of SHH or SIRT1 mitigated the
anti-inflammatory effects of fenofibrate in IMG microglial cells.

Conclusion:

Our findings suggest that fenofibrate may inhibit inflammatory responses by activating SIRT1 and SHH in IMG microglial cells. Our study
suggests that fenofibrate or targeting SHH molecule is a promising therapeutic strategy for neuroinflammation-associated conditions. Further
research with additional cell lines and in vivo models is needed to understand its therapeutic potential.
HIV Pre-Exposure Prophylaxis Cascade Stages Among Men Who Have Sex With Men With Sexually Transmitted Infections in China: Multicenter Cross-Sectional Survey Study
Authors: Yang Xue , Kang Wenting , Zhang Zhuoer , Tang Houlin , Zhang Dapeng , Sun Lijun , Li Zaicun , Liu An
Published: January 2025

Background

There is limited literature available regarding the knowledge and use of HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) with sexually transmitted infections (STIs).

Objective

This study’s objective was to explore the HIV PrEP cascade stages (knowledge, willingness to use, and use) among MSM with STIs in China, in order to promote the implementation of PrEP in this population.

Methods

A cross-sectional study was conducted using a respondent-driven sampling method in 19 cities in China, from January to August 2022. The study collected data on demographics, behaviors, and PrEP cascade stages from participants who were not infected with HIV and who self-reported being recently infected with STIs. After using chi-square tests or Fisher exact tests to analyze differences in the knowledge of PrEP, willingness to use PrEP, and PrEP use across different variables, multivariate logistic regression was used to analyze the influences of the different variables on PrEP cascade stages.

Results

By August 2022, following screening and exclusion, a total of 1329 MSM were included in the study. Among them, 85.55% (n=1137) had heard of PrEP, 81.57% (n=1084) expressed their willingness to use PrEP if engaging in high-risk HIV behaviors, 70.58% (n=938) had consulted a health care professional about PrEP, 62.98% (n=837) reported having used PrEP, and 46.35% (n=616) possessed a basic understanding of PrEP. The results of multivariate logistic regression analyses showed that the same factors significantly influenced both knowledge of PrEP and willingness to take PrEP, including age, education, marital status, income, condom usage, participation in group sex, HIV status of the most recent male sexual partner, and postexposure prophylaxis (PEP) usage. The factors significantly related to the PrEP use included income, engagement in commercial sex, participation in group sex, HIV status of the most recent male sexual partner, new drug usage, and PEP usage.

Conclusions

MSM with STIs were engaged with the PrEP cascade stages at a relatively high rate, but they lacked an understanding of PrEP and underestimated HIV risk. The prevalence of having a basic understanding of PrEP was lower than PrEP usage, and this suboptimal awareness could impede PrEP efficacy and lead to risk compensation.
Validation of Sleep Measurements of an Actigraphy Watch: Instrument Validation Study (Preprint)
Authors: Waki Mari , Nakada Ryohei , Waki Kayo , Ban Yuki , Suzuki Ryo , Yamauchi Toshimasa , Nangaku Masaomi , Ohe Kazuhiko
Published: January 2025

BACKGROUND

The iAide2 (Tokai) physical activity monitoring system includes diverse measurements and wireless features useful to researchers. The iAide2’s sleep measurement capabilities have not been compared to validated sleep measurement standards in any published work.

OBJECTIVE

We aimed to assess the iAide2’s sleep duration and total sleep time (TST) measurement performance and perform calibration if needed.

METHODS

We performed free-living sleep monitoring in 6 convenience-sampled participants without known sleep disorders recruited from within the Waki DTx Laboratory at the Graduate School of Medicine, University of Tokyo. To assess free-living sleep, we validated the iAide2 against a second actigraph that was previously validated against polysomnography, the MotionWatch 8 (MW8; CamNtech Ltd). The participants wore both devices on the nondominant arm, with the MW8 closest to the hand, all day except when bathing. The MW8 and iAide2 assessments both used the MW8 EVENT-marker button to record bedtime and risetime. For the MW8, MotionWare Software (version 1.4.20; CamNtech Ltd) provided TST, and we calculated sleep duration from the sleep onset and sleep offset provided by the software. We used a similar process with the iAide2, using iAide2 software (version 7.0). We analyzed 64 nights and evaluated the agreement between the iAide2 and the MW8 for sleep duration and TST based on intraclass correlation coefficients (ICCs).

RESULTS

The absolute ICCs (2-way mixed effects, absolute agreement, single measurement) for sleep duration (0.69, 95% CI –0.07 to 0.91) and TST (0.56, 95% CI –0.07 to 0.82) were moderate. The consistency ICC (2-way mixed effects, consistency, single measurement) was excellent for sleep duration (0.91, 95% CI 0.86-0.95) and moderate for TST (0.78, 95% CI 0.67-0.86). We determined a simple calibration approach. After calibration, the ICCs improved to 0.96 (95% CI 0.94-0.98) for sleep duration and 0.82 (95% CI 0.71-0.88) for TST. The results were not sensitive to the specific participants included, with an ICC range of 0.96-0.97 for sleep duration and 0.79-0.87 for TST when applying our calibration equation to data removing one participant at a time and 0.96-0.97 for sleep duration and 0.79-0.86 for TST when recalibrating while removing one participant at a time.

CONCLUSIONS

The measurement errors of the uncalibrated iAide2 for both sleep duration and TST seem too large for them to be useful as absolute measurements, though they could be useful as relative measurements. The measurement errors after calibration are low, and the calibration approach is general and robust, validating the use of iAide2’s sleep measurement functions alongside its other features in physical activity research.
ENABLE: App-based digital capture and intervention of patient-reported quality of life, adverse events, and treatment satisfaction in breast cancer - study protocol for a randomized controlled trial (Preprint)
Authors: Deutsch Thomas M. , Volmer Léa L. , Feisst Manuel , Bodenbeck Laura , Hassdenteufel Kathrin , Tretschock Lara , Breit Christiane , Stefanovic Stefan , Bauer Armin , Anders Carolin , Weinert Lina , Engler Tobias , Hartkopf Andreas D. , Pfeifer Nico , Escher Pascal , Mausch Marc , Heinze Oliver , Suetterlin Marc , Brucker Sara Y. , Schneeweiss Andreas , Wallwiener Markus
Published: January 2025

BACKGROUND

In recent years, the treatment of breast cancer has taken the path towards personalized medicine. Based on individual tumor biology, therapy tailored to the particular subtype of cancer is increasingly being used. The aim is to find the most suitable therapy for the disease. However, the success of therapy depends to a large extent on the patient's adherence to treatment. This, in turn, depends on how the therapy is tolerated and how the treatment team cares for the patient. Patient-centered care seeks to identify and address the individual needs of each patient and to find the best form of care for that person.

OBJECTIVE

In order to improve comprehensive oncological care of breast cancer patients, the ENABLE trial digitally recorded the health-related quality of life (HRQoL), adverse events (AEs), and patient satisfaction using a mobile smartphone application (app), responded individually to reported AEs, and offered assistance.

METHODS

Breast cancer patients were eligible to participate in the study before neoadjuvant, adjuvant, post-neoadjuvant, or palliative systemic therapy against breast cancer was initiated at Heidelberg, Mannheim and Tuebingen university hospitals. After 1:1 randomization into an intervention and a control arm, HRQoL assessments were performed at six fixed time points during the therapy using validated questionnaires. In the intervention group, HRQoL was also assessed briefly every week using a visual analog scale (EQ-VAS). In cases of significant deterioration, therapy-associated side effects were assessed in a graduated manner, recommendations were sent to the patient, and the treatment team was informed. Additionally, the app served as an "eHealth companion" for education, training, and organizational support during therapy.

RESULTS

Recruitment started in March 2021; follow up was completed in February 2024.

CONCLUSIONS

Participation in the intervention arm is expected to improve treatment satisfaction, adherence, detection, and timely treatment of critical AEs. The close-meshed, weekly, brief QoL assessment will also be tested as a screening tool to detect relevant side effects during therapy. The study offers a more objective QoL assessment across treatment strategies.

CLINICALTRIAL

DRKS (German Clinical Trials Register)-ID: DRKS00025611
Ethical approval: S-658/2020
Research on construction of lung cancer knowledge graph based on large language model (Preprint)
Authors: Zhou Chunfang , Gong Qingyue , Zhan Wendong , Zhu Jinyang
Published: January 2025

BACKGROUND

Medical text data commonly exhibits unstructured characteristics, and processing and applying this diverse data requires a broad range of domain knowledge and professional backgrounds.

OBJECTIVE

Given that conventional methods for constructing lung cancer knowledge graphs require substantial amounts of annotated data and entail high costs, a novel approach is proposed for efficiently mining lung cancer knowledge triples, leveraging the power of large language model technology.

METHODS

The Knowledge Graph Large Model (KGLM) model was developed through meticulously crafted prompts and the implementation of model fine-tuning strategies. Meanwhile, semi-structured clinical data and structured public graph data were integrated, and utilizing Jaccard coefficients along with the entity alignment method based on SBERT, the Lung Cancer Knowledge Graph (LCKG) was successfully established.

RESULTS

The experimental results underscore the significance of fine-tuning large language models, with the KGLM model demonstrating exceptional performance in large-scale data relationship extraction tasks, achieving an F1 score of 82%, marking a 25% improvement over baseline models. Furthermore, comparisons with traditional deep learning methodologies provide additional validation of the efficacy and rationality of employing large language models for knowledge graph construction.

CONCLUSIONS

The approach effectively handles unstructured lung cancer data, furnishing crucial support for clinical decision-making and intelligent question-answering related to lung cancer, while also charting a new course for knowledge graph construction methodologies.
REmote monitoring by viQtor Upon implemEntation on a Surgical departmenT (REQUEST-trial); a prospective implementation study (Preprint)
Authors: Jerry Ephrahim
Published: January 2025

BACKGROUND

Background
Continuous monitoring of patients’ vital signs is critical for early detection of postoperative complications. Traditional manual monitoring by nursing staff is time-consuming and provides only intermittent data. Wearable devices offer continuous monitoring capabilities, potentially enhancing early warning systems, reducing nurse workload, and facilitating earlier patient discharge. However, research on their implementation and effectiveness in clinical settings remains limited.

OBJECTIVE

Objectives
This study aims to evaluate the implementation and feasibility of continuous monitoring using PPG-sensor technology (viQtor device) in a surgical ward. It will also assess the impact on nursing workload and the usability of the technology.

METHODS

Methods
The REQUEST study is a prospective observational study conducted over eight months in a surgical ward. The vital signs of 500 postoperative patients will be continuously monitored using the viQtor device, which measures heart rate, respiratory rate, and oxygenation. The study will be conducted in two phases: a baseline period with manual spot-checks three times daily, followed by a phase where manual checks are conducted on demand. Outcomes will be evaluated using the Integrated Workload Scale (IWS) for nursing workload and a framework examining acceptability, appropriateness, feasibility, adoption, penetration, implementation cost, and sustainability. Data collection will also include device performance metrics, questionnaires (Evidence-Based Practice Attitude and System Usability Scale), and thematic analysis of focus groups.

RESULTS

Results
Enrollment will commence in October 2024. Training for staff is underway, and the full implementation of the viQtor device is expected by Month 5. Initial findings are anticipated in early 2025, with outcomes such as feasibility, nursing workload, and device usability under evaluation.

CONCLUSIONS

Conclusions
The REQUEST study will provide valuable insights into the practical implementation of continuous monitoring in a surgical ward, focusing on its impact on workload and overall feasibility. The findings aim to guide future integration of wearable technology into clinical practice, improving patient outcomes and optimizing resource allocation.

CLINICALTRIAL

Trial Registration ClinicalTrials.gov: NCT06574867, Registered on 27 August 2024
Effect of Operating Condition of Natural Dye Production from Red Spinach (Amaranthus Dubius ) using Solvent Extraction
Authors: Yahya Asdarina , Sulaiman Siti Nur Azeera , Maryudi Maryudi
Published: January 2025

Due to synthetic dyes’ health and environmental impacts, there is a growing demand for natural dyes as a sustainable alternative. This study investigates the production of natural dye from red spinach (Amaranthus dubius) using solvent extraction methods. The dominant pigment, betacyanin, was extracted and analyzed under various operating conditions. The effects of different solvents (water, ethanol, acetone, ethanol-water, and acetone-water), extraction temperatures (20°C, 40°C, 60°C, and 80°C), and extraction times (30, 60, 90, and 120 minutes) on dye yield were evaluated. The highest yield of 34% was achieved using acetone water (50:50) at 60°C for 60 minutes. The extracted dyes were analyzed using a chroma meter. These findings suggest optimal conditions for maximizing dye yield from presenting a viable alternative to synthetic dyes at 60℃ and 60 minutes can get ca. 34% of yield. FTIR analysis showed that the extracted natural dye contains antioxidants compared with synthetic dye.
Sulphurization of Kapok (Ceiba Pentandra ) Seed Oil via H2S Bubbling Under UV Radiation and The Product’s Performance as Extreme Pressure Additives for Lubricant
Authors: Sukirno Sukirno , Cleo  , Devan
Published: January 2025

In this research, extreme pressure additive (EP additive) for lubricants was manufactured from Ceiba pentandra seed oil (kapok oil) via sulfurization reaction at a low temperature (50°C) by using a photochemical reactor under UV-radiation (254 nm). The sulfurization process was conducted by recirculating bubbling H2S gas through kapok oil filled in a glass chamber. The sulfurization reaction has been proven successful, as shown from the FTIR spectrum of the sulfurized kapok oil, where carbon-sulfur bond (C-S) vibration appears at a peak of 581 cm-1. It was also found that within 20 hours, the recirculated-bubbling sulfurization produced sulfurized kapok oil with a sulfur content of 32,682 ppm, viscosity of 72.17 cSt, and density of 0.92 g/cm3.  The product was then used as an EP additive by mixing it with mineral oil and testing it using a 4-ball wear tester.  The mineral oil containing sulfurized kapok oil 10% v/v or equal to sulfur content 3,268 ppm reduced wear amount by 98%. Results of corrosion tests via copper strip corrosion ASTM D130 showed that the copper strip’s color only had level 1a, meaning that mineral oil containing 10% Kapok oil as EP additives is not corrosive.
Analysis of Inter-Island Rice Supply Chain at Rice Mill in Pinrang Regency
Authors: Umar Karmila
Published: January 2025

The supply chain of agricultural products is the entire production process from cultivation, processing, distribution, and marketing, to the products produced to the hands of consumers. The supply chain consists of various stakeholders who are involved either directly or indirectly. Thus, the supply chain is an integrated marketing unit that includes the integration of stakeholders and products to provide satisfaction to customers. Pinrang Regency is one of the largest rice-producing districts in South Sulawesi. The purpose of this study is to analyze the structure of the inter-island rice supply chain in rice mills in Pinrang Regency, analyze the relationship pattern in the inter-island rice supply chain in Pinrang Regency, analyze the influence of inter-island traders on the rice market in Pinrang Regency, the analysis used is descriptive analysis, panel data regression analysis. The results of this study indicate that the structure of the rice supply chain in the mill starts from farmers who supply grain to the mill, then the mill sells rice to inter-island traders, then the mill sells to wholesalers and retailers then finally the mill sells rice to direct consumers. The rice supply chain in each mill has 3 flows, namely product flow, financial flow and information flow. The pattern of relationships in the inter-island rice supply chain, namely the raw material supply channel (grain), the rice product distribution channel (milling), and the inter-island channel cooperate in completing a purchase transaction and the pattern of relationships in the supply chain uses a general trading partnership pattern. The results of the study using the Common Effect Model (CEM) show that the variable amount of production has a positive and significant effect on the volume of inter-island shipments. The destination price variable has a positive and significant effect on the volume of inter-island rice shipments. Then the variable Shipping cost has a positive and significant effect on the volume of inter-island rice shipments.
A Business Development Strategy of Macoa Chocolate Product at cv. Putra Mataram Polewali Mandar
Authors: Darwis Muh Fikriadi
Published: January 2025

Cocoa is one of the important plantation commodities that plays a significant role in Indonesia's economy. CV. Putra Mataram is an industry in Polewali Mandar, South Sulawesi, that processes cocoa into Macoa chocolate products. The challenges faced by the company in developing Macoa chocolate products include its less strategic geographic location, limited labor during production and marketing, inadequate production equipment for small businesses, insufficient funding for large stock procurement, numerous competitors for Macoa chocolate products, lack of continuous supply of fermented cocoa beans, rising raw material costs, and unpredictable weather. This study aims to analyze the priority strategies suitable for developing Macoa chocolate products at CV. Putra Mataram in Polewali Mandar. The research methods used were TOWS and QSPM analysis. The results showed that the appropriate strategy for the business development of Macoa chocolate products at CV. Putra Mataram, based on the IE matrix, falls into cell II, with weighted scores from internal and external factors (2.97 and 3.23), placing CV. Putra Mataram in the "Hold and Maintain" position. This strategy indicates that the marketing activities of Macoa chocolate products require a "hold and maintain" approach. Based on the TOWS analysis, nine alternative strategies were identified. The priority strategies for developing Macoa chocolate products at CV. Putra Mataram, based on QSPM analysis, include improving the quality of Macoa chocolate products and expanding partnerships in various cities/regions. The highest total attractiveness score (TAS) for the SO strategy was 6.26.
Herbal and Coffee Plant Agrotourism Development Model in Karo Regency, North Sumatra of Indonesia
Authors: Munthe Theodora Ginting
Published: January 2025

The goal of this study is to examine potential development strategies for herbal plant agrotourism in Seberaya Village, Karo Regency. This study uses a qualitative descriptive method. The population includes managers, farmer groups, communities, and government stakeholders, with a sample of 80 people selected by purposive sampling. We collected data through observation, focus group discussions (FGD), interviews, and questionnaires. Data analysis used the SWOT, IFAS, and EFAS analysis methods. The development of herbal plant agrotourism involves several key programs, such as environmental conservation, enhancing aesthetic value and natural beauty, and boosting recreational value. This program also aims to establish agrotourism as a hub for scientific activities and generate economic benefits for the community and region. The SWOT analysis reveals that this agrotourism falls into quadrant I (SO strategy), characterized by average internal factors and moderate external factors. The regional tourism development plan has the potential to incorporate this agrotourism as a new attraction. The QSP matrix results indicate that focusing on herbal plant cultivation and transparently managing agrotourism with community and farmer groups is the best strategy. The proposed cooperation model is participatory management, where the government acts as a motivator and facilitator, the private sector manages and develops agrotourism, and farmers and communities are involved in cultivation and tourism. Fostered farmer groups will train and assist farmers to ensure effective management. We propose a participatory management model for the development of herbal agrotourism in Seberaya Village, which involves farmers and the community in the development process and the formation of farmer groups. Each stakeholder will play a specific role in the development of this agrotourism.
Hacinamiento entre rejas: una aproximación al sistema de cupos carcelarios
Authors: Chaiña Durán Renzo Joel
Published: January 2025

El sistema de cupos carcelarios es una de las medidas menos tratadas por la academia en lo que atañe al hacinamiento de las prisiones, pese a encontrar sustento normativo en el principio XVII de la Resolución 1/08, de la Comisión Interamericana de Derechos Humanos y ser considerado por algunos como el único modo de poner límite a la actual tendencia global deencarcelamiento masivo. La presente contribución tuvo como finalidad explorar las pautasde aplicación del mencionado sistema y reflexionar sobre su vinculatoriedad tomando como referencia al ordenamiento peruano, habiéndose con este propósito analizado diversas fuentes literarias y normativas. Se concluyó que, el sistema de cupos tiene potencial para disminuir la reclusión de forma significativa y evitar el retorno a una situación penitenciaria crítica, pues entraña: el establecimiento de una comisión multisectorial que determine los cupos carcelarios y fiscalice su cumplimiento; la publicación y control del registro de los cupos declarados y ocupados; la regulación de las medidas de deshacinamiento y su procedimiento de aplicación; así como, la prohibición de hacinar, con la correspondiente sanción en caso de inobservancia.
Digitalization of civil proceeding in brics countries
Authors: Izralovsky Nikolay R. , Petrova Antonina S.
Published: January 2025

In the present article, the authors aim to analyze the current issues related to the implementation of digital technologies and artificial intelligence (AI) technologies in civil proceedings in the BRICS countries. The novelty of the research lies in its generalization of the experience of the BRICS countries in accordance with the latest developments in doctrine, practice and legislation in the post-COVID19 period. On the basis of comparative legal analysis, the authors consistently describe the experience of all the states that are members of the BRICS organization in 2023. The key conclusions that the authors reach are the followings: the level of digitalization differs in the BRICS countries in terms of qualitative and quantitative indicators, which leads to a general slowdown in this process in the countries of this union. In order to overcome this obstacle, states need to first develop legislative regulation of the digitalization process at the national level, provide courts with technological equipment and improve the literacy level of judges and court staff. In addition, BRICS countries need to take into account the experience of other BRICS countries in order to build synergies with each other, as well as to borrow the strengths of the digitalization process in other countries and integrate it into their civil society processes. Consolidation in the development of the introduction of new technologies in civil proceedings among the BRICS countries is necessary.
Construyendo la religión de derechos humanos: discurso de Naciones Unidas sobre cambio climático
Authors: Compte Nunes Guillem
Published: January 2025

El presente artículo estudia cómo se está construyendo el paradigma normativo de los derechos humanos con base en el discurso de Naciones Unidas sobre el cambio climático, uno de los problemas globales más acuciantes de la actualidad. Se conceptualiza este paradigma como religión y se hace énfasis en dos modos constructivos: la movilización discursiva de mitos, orientados a sacralizar elementos de la religión de derechos; y cómo ésta compite simbólicamente con la religión civil (Rousseau). Para ello, se realizó un análisis narrativo de un corpus de intervenciones orales del secretario general en el primer cuatrimestre de 2023. Como resultado este discurso vehiculiza el mito del Éxodo bíblico, actualizado en un Éxodo climático, lo cual sacraliza a la ONU; y que, pese a una aparente crítica a estructuras de poder estadocéntricas, la religión de derechos se muestra subordinada a la religión civil, cosa que plantea dudas acerca de su construcción.
INTERCAMBIO ACADÉMICO: UNA REFLEXIÓN SOBRE LA PRÁCTICA PEDAGÓGICA DE UNA DOCENTE EN FORMACIÓN
Authors: Chiquillo Varela María Fernanda
Published: January 2025

Este trabajo presenta una reflexión sobre el proceso formativo de las prácticas pedagógicas en matemática en un intercambio académico, mediante la experiencia de una estudiante de licenciatura en matemáticas de la Universidad del Atlántico, Colombia en su intercambio en la Universidad del Bío-Bío, Chillán-Chile durante el periodo académico 2024-1. A partir de las experiencias vividas durante este periodo académico, se visualizan las características de la práctica profesional pedagógica y los aportes de diferentes entes académicos que hicieron parte de este proceso de formación. Las condiciones de la práctica en Chile, enriquecen la formación docente debido a la oportunidad de conocer el sistema educativo, la experiencia por su parte, permite adquirir nuevas perspectivas académicas y profesionales al interactuar en una cultura distinta.
TRES PERSPECTIVAS PEDAGÓGICAS BASADAS EN GÉNEROS DISCURSIVOS: REFLEXIONES PARA ENSEÑAR A ESCRIBIR INFORMES DE LABORATORIO
Authors: Sagua Sierra Benjamín
Published: January 2025

La alfabetización académica es una práctica de suma importancia. Se trata de un proceso mediante el cual las personas adquieren competencias para operar con textos propios de los ámbitos universitario y profesional. Sin embargo, la situación de estas competencias es problemática en Latinoamérica. Existen pocos espacios previos a la enseñanza superior en los que las personas tienen la posibilidad de desarrollar habilidades de lectoescritura en campos especializados. Este panorama resulta desafiante para programas como los de Ciencia 2030 de las universidades beneficiadas, que en su mayoría buscan incorporar la enseñanza explícita de habilidades comunicativas propias del quehacer académico en carreras de pregrado de Ciencia y Teconología. Por ello, el objetivo que se plantea esta discusión es reflexionar en torno a la aplicabilidad de tres modelos pedagógicos basados en género discursivo para la enseñanza de la producción de informes de laboratorio en un curso de química general. A pesar de las evidentes diferencias entre los modelos pedagógicos, es posible elaborar una propuesta que contemple las ventajas de cada uno y materializar un marco metodológico para la enseñanza de la lectoescritura en contextos académicos que sea organizado y coherente con las múltiples necesidades de los estudiantes.
Evaluation of protective properties of biotextile with incorporated amber nano/micro particles against the Low-Frequency Electromagnetic Fields (ELF-EMF)
Authors:   University of Latvia, Institute of Biology, Jankevica Līga , Žagata Kārlis , Apine Agnija , Dubova Ilze , Butkauskas Dalius , Gobiņš Valters , Lashenko Inga , Grauda Dace ,   Nature Research Centre,   JLU Technologies Ltd
Published: January 2025

The impact of extremely low frequency electromagnetic field (ELF-EMF) on living organisms and the identification of their threshold levels remain uncertain. Amber nanoparticles and microparticles are being explored as potential raw materials used for production of innovative biotextiles. This study aimed to develop methods for assessing the protective properties of biotextiles against LF-EMF including testing the influence of a novel biotextile with incorporated amber particles on growth parameters of model bacteria and fungi species.
The assessment of biotextile properties is based on comparison of mycelial growth in Petri dishes of fungi Chaetomium globosum Kunze: Fries (ATCC® 6205TM), and the growth rates of bacteria Enterococcus faecalis (Andrewes and Horder 1906) Schleifer and Kilpper-Bälz 1984 (NCTC 12697) and Escherichia coli (Migula 1895) Castellani and Chalmers 1919 (AL) (NCTC 12241), grown in flasks wrapped and unwrapped in fabrics with incorporated amber particles under LF-EMF exposure. While no significant differences were observed in the growth rate of E. faecalis under LF-EMF exposure, regardless of fabric wrapping, the biotextile with amber particles demonstrated a statistically significant protective effect (P < 0.01) inducing growth rate changes in E. coli.
Marking greylag goose Anser anser with colour neckbands in Latvia – the first results
Authors:   University of Latvia, Faculty of Medicine and Life Sciences, Institute of Biology, Stīpniece Antra , Stīpnieks Andris , Bētiņš Jānis , Boiko Dmitrijs , Endziņš Toms , Keišs Oskars , Laubergs Artūrs , Bauga Ilmārs
Published: January 2025

During the breeding seasons of 2021–2024, 55 greylag geese were marked with leg and neck bands (2 adults, 53 juveniles). Since then, 47 resighting records for 19 birds have been obtained. Before the start of the hunting seasons all resightings came from ringing sites in Latvia. Starting from mid-August birds appear to use Nemunas River delta region in Lithuania, from where resightings came from fish-ponds, a natural lake Kroku Lanka and from arable land. From September till December our geese have been reported from Poland, in October and November – from Germany. The resightings lie in SW direction from Latvia and up to 740 km from the ringing sites.
Sumbangan Izz al-Din Ibn Abd Salam (m. 660H) dalam Perkembangan Sejarah dan Tamadun Islam Contribution of Izz al-Din Ibn Abd Salam (d. 660H) in the Development of Islamic History and Civilization
Authors: Jaafar Syed Mohd Jeffri Syed , Man Sa’adan , (Corresponding Author) Norhidayah Pauzi; Mohd Hafiz Jamaluddin , Harun Muhammad Safwan
Published: January 2025

Izz al-Din Ibn Abd Salam was one of the most significant figures in the history of Islamic development, particularly in the field of Islamic jurisprudence. His firmness and unwavering principles earned him great respect from both leaders and society, to the extent that he was honoured with titles such as al-Sultan al-Ulama and al-ba’i al-Umara. His contributions to religion and society were so profound that he was appointed as a mufti in two different kingdoms. Despite his influence, research reveals that discussions regarding the factors that contributed to his outstanding prominence remain scarce. This paper aims to examine the factors that shaped the character and prominence of Izz al-Din Ibn Abd Salam throughout his life. The study adopts a qualitative research methodology, gathering data through literature review and analysing it using inductive, deductive, and thematic methods. The research finds that Izz al-Din Ibn Abd Salam was a man of strong principles and firm in defending his views, as evidenced by his fatwas, which were immune to influence by individuals with vested interests. Various factors influenced his distinguished stature, including his scholarly knowledge, socio-political environment, societal influences, and his steadfast adherence to religious beliefs.
Musu' Selleng: Deconstruction of the Text and Context of Islamization in South Sulawesi, Indonesia
Authors: Amir Muhammad , Muhammad Nur Ichsan Aziz Muhammad Nur Ichsan Aziz , (Corresponding Author) Rismawidiawati , Muslim Abu , Hadrawi Muhlis , Fahimah Ilyas Husnul
Published: January 2025

This article discusses the Musu’ Selleng in the process of Islamization in South Sulawesi in the 17th century. The data is presented using the historical method with a deconstruction approach to the text of historical events in the past. Islamization in South Sulawesi is often associated with political practices and community activities during the maritime trade network that strengthened the position of Islam as the religion of society in the past. This paper reveals that the Islamization process in South Sulawesi has unique dynamics based on text analysis and the context of events that influence the Islamization process has two important meanings in Indonesia, namely as a socio-religious role and a political role that strengthens the structure and order of a community. The expansion of Islam in South Sulawesi was influenced by the three major Islamic powers, namely Gowa-Tallo, Bone, and Wajo, which positively impacted the development of Islam in South Sulawesi. The main objective of this article is to try to deconstruct the historical events of Islam in South Sulawesi based on the texts and contexts that influenced their development. The integration of the Islamization process in South Sulawesi will strengthen the view of the current currents of Islamization that are developing in Indonesia.
Kitab Kuning and Religious Moderation: A Study on State Islamic Universities in Indonesia
Authors: (Corresponding Author) Sahkholid Nasution , Asari Hasan , Al-Rasyid Harun
Published: January 2025

Indonesia is a multi-religious country that is constantly seeking ways to promote religious moderation. One of the recently adopted strategies is to empower Kitab Kuning, which are the classical source books used in pesantren (Islamic boarding schools), at Maʻhad al-Jāmiʻah of State Islamic Universities. The objective of this study is to provide qualitative-descriptive analyses of the contents of Kitab Kuning related to religious moderation, the teaching methods of Kitab Kuning, and the extent to which moderation is practiced in Maʻhad’s daily life. The data for the study were obtained through in-depth interviews, focus group discussions, site observations, and content analyses of related documents. The participants were heads of Maʻhad al-Jāmiʻah, instructors, students, and administrators. The data was processed using the procedures suggested by Miles and Huberman. The findings indicate that Maʻhad al-Jāmiʻah intentionally uses Kitab Kuning to propagate basic values of Islam Wasatiyah, such as love, respect, balance, modesty, justice, and fairness. The teaching strategies adopted at Maʻhad are based on pesantren’s tradition with a focus on contextualization, which enables the moderation values to be implemented in students’ daily lives. These values have played a vital role in maintaining healthy relations between students from different cultural and religious backgrounds. Therefore, Kitab Kuning should be seen as an alternative strategy to ensure Islam Wasatiyah in Indonesia. The fact that the learners are university students is significant, as they can propagate moderation into the wider society once they graduate.
Análisis de sentimientos sobre la percepción de la realización de clases remotas en la Uniagustiniana
Authors: Triana Laverde Juan Gabriel
Published: January 2025

En la Uniagustiniana se llevó a cabo una jornada de un día de clases remotas, con el fin de preparar a la comunidad académica en caso de que, por motivos de fuerza mayor, sea necesario realizar las actividades académicas en dicha modalidad. Para conocer la percepción de los estudiantes que se encuentran cursando asignaturas de ciencias básicas, en los diversos programas que ofrece la institución, se realizó una breve encuesta con metodología mixta, compuesta por varias preguntas cerradas para una escala de Likert, principalmente para determinar si los estudiantes cuentan con las condiciones adecuadas para tomar clases en modalidad remota, y con una pregunta abierta en la que los estudiantes pueden dar su opinión respecto a la jornada. Para determinar si la jornada fue exitosa, se analizan los comentarios realizados por los estudiantes y se implementa un análisis de sentimientos, se emplea el software Python ya que cuenta con librerías para el procesamiento del lenguaje natural en las que incorpora herramientas y diccionarios específicos para este tipo de análisis.
Modelo de Competencias TIC del Ministerio de Educación Nacional de Colombia: Usos, implementación y resultados en la Práctica Pedagógica
Authors: Hernández Suárez César Augusto , Hernández Albarracín Juan Diego , Rodríguez Moreno Javier
Published: January 2025

El artículo analiza la implementación y el impacto del modelo de competencias TIC desarrollado por el Ministerio de Educación Nacional de Colombia. Este modelo, lanzado en 2013, busca integrar las TIC en la educación para mejorar la enseñanza y el aprendizaje. El estudio aborda cómo las TIC facilitan el acceso a la información, fomentan la innovación pedagógica y desarrollan habilidades digitales esenciales. A través de una revisión sistemática de la literatura, análisis temático y una revisión crítica, el artículo evalúa la adopción de las competencias TIC en distintos contextos educativos, identificando fortalezas, desafíos y áreas de mejora. Los resultados indican que, a pesar de los avances en infraestructura tecnológica, el uso efectivo de las TIC en las aulas sigue siendo limitado. La formación continua y contextualizada de los docentes es fundamental para una integración efectiva de las TIC, promoviendo la equidad educativa y la calidad en la enseñanza.