bluuebunny/crossref_metadata_2025 huggingface dataset:
Spectral Effects of Supplemental Greenhouse Radiation on Growth and Flowering of Annual Bedding Plants and Vegetable Transplants
Authors: Poel Brian R. , Runkle Erik S.
Published: October 2017

Supplemental radiation (SR), traditionally provided by high-pressure sodium (HPS) lamps, is recommended for greenhouse production of seedlings during radiation-limiting conditions. Light-emitting diodes (LEDs) have emerged as an appealing alternative to HPS lamps primarily because they can provide SR at improved energy efficiencies, they have longer fixture lifetimes, and the radiation spectrum can be tailored to potentially manipulate plant morphology by targeting radiation absorption of specific photoreceptors. We grew seedlings of three annual bedding plants and two vegetable transplants in greenhouses at 20 °C under a 16-h photoperiod under six SR treatments: five that delivered a photosynthetic photon flux density (PPFD) of 90 μmol·m−2·s–1 from HPS lamps (HPS90) or LEDs [four treatments composed of blue (B; 400–500 nm), red (R; 600–700 nm), far red (FR; 700–800 nm), and/or white LEDs] and one that delivered 10 μmol·m−2·s–1 from HPS (HPS10) lamps as a control with matching photoperiod. The LED treatments, defined by the percentages of B, green (G; 500–600 nm), and R radiation, were B10R90, B45R55, B10G5R85, and B12G20R68 + FR (FR at 12 μmol·m−2·s–1). At transplant, leaf area and seedling height were similar among 90 μmol·m−2·s–1 treatments in all species except snapdragon (Antirrhinum majus), in which seedlings grown under B12G20R68 + FR had 62% greater leaf area than those grown under B45R55 and were 47%, 18%, 38%, and 62% taller than those grown under HPS90, B10R90, B10G5R85, and B45R55, respectively. After transplant and finishing under the same SR treatments, snapdragon flowered on average 7 days earlier under the B12G20R68 + FR treatment than the other LED treatments, whereas geranium (Pelargonium ×hortorum) grown under B45R55 and B12G20R68 + FR flowered 7 to 9 days earlier than those under the B10G5R85 and B10R90 treatments. Seedlings of each species grown under the HPS10 treatment accumulated less dry weight and took longer to flower compared with seedlings under the other SR treatments. We conclude that radiation quality of SR has relatively little effect on seedling growth and subsequent flowering although in some crops, flowering may be earlier when SR includes FR radiation.
Agronomic and Economic Feasibility of Tomato and Lettuce Intercropping in a Soilless System as a Function of the Electrical Conductivity of the Nutrient Solution
Authors: Loeiro da Cunha-Chiamolera Tatiana Pagan , Urrestarazu Miguel , Filho Arthur Bernardes Cecílio , Morales Isidro
Published: October 2017

An intercrop is studied here as a new way of farming in soilless systems within a protected environment. To estimate the efficiency of intercropping in this cultivation system, an experiment was conducted to evaluate the effect of the electrical conductivity (EC) of the nutrient solution (2.0, 2.5, and 3.0 dS·m−1) on lettuce and tomato plants and on the agronomic and economic feasibility of the intercrop compared with monoculture. The results indicated that a moderate increase in EC from 2.0 to 3.0 dS·m−1 did not exert any important effect on tomato plant production or quality but did cause a decrease in lettuce yield in both the first and second crops. Intercropping was only feasible for lettuce when the tomato and lettuce plants were transplanted on the same day. The highest tomato (G class) and lettuce yields were achieved at an EC of 2.5 dS·m−1; this condition resulted in the highest intercrop profitability (0.53 €·m−2 more) when compared with tomato monoculture.
Cross-genera Transferability of Microsatellite Loci for Asian Palmyra Palm (Borassus flabellifer L.)
Authors: Pipatchartlearnwong Kwanjai , Swatdipong Akarapong , Vuttipongchaikij Supachai , Apisitwanich Somsak
Published: October 2017

Asian Palmyra palm, found throughout south and southeast Asia, is important for local economies, especially for sugar palm production. Unlike its related species, such as oil palm and coconut, only a few genetic markers are available for Asian Palmyra palm. In this study, we tested the transferability of molecular markers derived from oil palm, and a set of selected markers were used for evaluating the diversity of Asian Palmyra palm growing in Thailand. From 545 primer pairs of expressed sequence tag-simple sequence repeat (EST-SSR) and genomic simple sequence repeat (gSSR) markers, 317 (58.17%) primer pairs were able to amplify the Asian Palmyra palm DNA, and 19 (5.99%) pairs were polymorphic. After extensively genotyping 164 samples from 12 populations, we obtained 25 loci with the polymorphic information content (PIC) average of 0.37 and allele numbers ranging from one to five. The observed and expected heterozygosity ranged from 0 to 1 and 0 to 0.76, respectively. A dendrogram showed separation of the palm populations into two clades, between north-eastern and southern-central regions. This study provides a set of microsatellite markers for use in further genetic studies of Asian Palmyra palm.
Fractionation of Inorganic Phosphorus and Aluminum in Red Acidic Soil and the Growth of Camellia oleifera
Authors: Yuan Jun , Huang Liyuan , Zhou Naifu , Wang Hui , Niu Genhua
Published: October 2017

Aluminum (Al) toxicity and phosphorus (P) deficiency are two crucial factors limiting the production of Camellia oleifera, which is grown commercially in red acidic soils in Southern China. The current study characterized the different forms of P and Al in the red acidic soils of C. oleifera plantations. Soil and plant tissue samples taken from 32 Camellia plantations across Hunan province were analyzed. Furthermore, a pot experiment with nutrient solutions of different Al and P contents was carried out to investigate P and Al uptake and their effect on C. oleifera growth. The results showed that the P content extracted by NaOH (Fe-P) was the highest in all types of soil samples (rhizosphere, 0–20 cm, and 20–40 cm zones), followed by P extracted by NH4F (Al-P), H2SO4 (Ca-P), and Na3C6H5O7 (O-P). HCl (In-Al), NH4Ac (Ha-Al), and Na4P2O7·10H2O (Or-Al) extracted Al were the main forms and accounted for 22.8%, 23.1%, and 23.8% of total Al, respectively. KCl extracted Al (Ex-Al) contents in the rhizosphere, 0–20 cm, and 20–40 cm soil zones were 4.78, 4.86, and 4.59 mg·kg−1, respectively. P contents in roots, young leaves, and old leaves were 0.80, 0.82, and 0.64 mg·kg−1, respectively. The highest Al content of 11.35 g·kg−1 was found in the old leaves, followed by roots and young leaves. Correlation analyses revealed that P in roots was positively associated with available P (AP) and Al-P in rhizosphere. P in roots and young leaves also had a positive correlation with Ex-Al, whereas Al in old leaves was positively correlated with In-Al and total Al. Significant correlations between Al-P, Ex-Al, and AP were detected. The pot experiment indicated that adding Al or P alone increased plant growth and Al or P uptake, respectively. When adding both Al and P, significant synergistic effect was found. These results suggest that Al is beneficial to C. oleifera, which may be the adaptive mechanism of C. oleifera to use insoluble Al-P in red acidic soil.
Foliar Applications of Calcium and Boron Do Not Increase Fruit Set or Yield in Northern Highbush Blueberry (Vaccinium corymbosum)
Authors: Arrington Matthew , DeVetter Lisa Wasko
Published: October 2017

Fruit set in northern highbush blueberry (Vaccinium corymbosum L.) can be low under certain climatic conditions, contributing to reduced yields in northwestern Washington. The mechanisms influencing fruit set are complex, but reduced fruit set may be associated with inadequate nutrient availability during critical stages of flowering, ovule fertilization, and initial fruit development. Calcium (Ca) and boron (B) are of particular interest for reproductive developmental processes and are frequently applied annually by growers in the Pacific Northwest region because of the perception that these nutrients enhance fruit set and corresponding yields. Evaluation of commonly applied products containing these nutrients and their effects on fruit set and yield are of specific importance to justify the application of these nutrients. To address this, commercially available fertilizers containing Ca and B were applied to ‘Draper’ and ‘Bluecrop’ blueberry as foliar sprays, either alone or in combination, during the 2015 and 2016 growing seasons in northwestern Washington. Treatments included calcium chloride (750 and 1500 ppm Ca), calcium sulfate (150 ppm Ca), and tetra borate (125 and 250 ppm B) foliar sprays, repeated six times per season every 7–10 days from early pink bud through petal fall. No significant increases were observed for fruit set, estimated yield, and fruit quality (firmness and berry weight) across the treatments. Increased concentrations of B were observed in leaf tissues in 2015 and 2016, and to a lesser extent fruit tissues. Calcium remained unchanged regardless of treatment and tissue type. Under the conditions of this study, foliar applications of Ca and B did not lead to increased fruit set or yield. This research suggests that other approaches should be explored to increase fruit set and corresponding yields of highbush blueberry grown in northwest Washington.
Anticancer and Reversing Multidrug Resistance Activities of Natural Isoquinoline Alkaloids and their Structure-activity Relationship
Authors: Qing Zhi-Xing , Huang Jia-Lu , Yang Xue-Yi , Liu Jing-Hong , Cao Hua-Liang , Xiang Feng , Cheng Pi , Zeng Jian-Guo
Published: October 2017

The severe anticancer situation as well as the emergence of multidrug-resistant
(MDR) cancer cells has created an urgent need for the development of novel anticancer
drugs with different mechanisms of action. A large number of natural alkaloids, such as
paclitaxel, vinblastine and camptothecin have already been successfully developed into
chemotherapy agents. Following the success of these natural products, in this review,
twenty-six types of isoquinoline alkaloids (a total of 379 alkaloids), including benzyltetrahydroisoquinoline,
aporphine, oxoaporphine, isooxoaporphine, dimeric aporphine, bisbenzylisoquinoline,
tetrahydroprotoberberine, protoberberine, protopine, dihydrobenzophenanthridine,
benzophenanthridine, benzophenanthridine dimer, ipecac, simple isoquinoline,
pavine, montanine, erythrina, chelidonine, tropoloisoquinoline, azafluoranthene,
phthalideisoquinoline, naphthylisoquinoline, lycorine, crinane, narciclasine, and phenanthridone,
were summarized based on their cytotoxic and MDR reversing activities against
various cancer cells. Additionally, the structure-activity relationships of different types of
isoquinoline alkaloid were also discussed. Interestingly, some aporphine, oxoaporphine,
isooxoaporphine, bisbenzylisoquinoline, and protoberberine alkaloids display more potent
anticancer activities or anti-MDR effects than positive control against the tested cancer
cells and are regarded as attractive targets for discovery new anticancer drugs or lead
compounds.
Electrochemical MIP-Sensors for Drugs
Authors: Yarman Aysu , Kurbanoglu Sevinc , Jetzschmann Katharina J. , Ozkan Sibel A. , Wollenberger Ulla , Scheller Frieder W.
Published: October 2017

In order to replace bio-macromolecules by stable synthetic materials in separation
techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional
monomers are polymerized together with the target analyte and after template removal
cavities are formed in the ”molecularly imprinted polymer” (MIP) which resemble the active
sites of antibodies and enzymes. Starting almost 80 years ago, around 1,100 papers on MIPs
were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric
electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance
(SPR). For the readout of MIPs for drugs amperometry, differential pulse voltammetry (DPV)
and impedance spectroscopy (EIS) offer higher sensitivity as compared with QCM or SPR.
Application of simple electrochemical devices allows both the reproducible preparation of
MIP sensors, but also the sensitive signal generation. Electrochemical MIP-sensors for the
whole arsenal of drugs, e.g. the most frequently used analgesics, antibiotics and anticancer
drugs have been presented in literature and tested under laboratory conditions. These
biomimetic sensors typically have measuring ranges covering the lower nano- up to millimolar
concentration range and they are stable under extreme pH and in organic solvents like nonaqueous
extracts.
DIABEO App Software and Telemedicine Versus Usual Follow-Up in the Treatment of Diabetic Patients: Protocol for the TELESAGE Randomized Controlled Trial (Preprint)
Authors: Jeandidier Nathalie , Chaillous Lucy , Franc Sylvia , Benhamou Pierre-Yves , Schaepelynck Pauline , Hanaire Hélène , Catargi Bogdan , Farret Anne , Fontaine Pierre , Guerci Bruno , Reznik Yves , Penfornis Alfred , Borot Sophie , Serusclat Pierre , Kherbachi Yacine , D'Orsay Geneviève , Detournay Bruno , Simon Pierre , Charpentier Guillaume
Published: October 2017

BACKGROUND

Self-management of diabetes minimizes the risk of macrovascular and microvascular complications, but understanding and/or adherence to self-management recommendations is often suboptimal. DIABEO is a smartphone app (downloaded via the internet) used to calculate bolus insulin doses. A previous study (TELEDIAB 1) showed that the use of DIABEO was associated with a significant improvement in glycemic control in patients with poorly controlled type 1 diabetes mellitus, particularly when combined with teleconsultations with physicians.

OBJECTIVE

Here, we present the protocol for a new study (Suivi A Grande Echelle d’une cohorte de diabétiques de type 1 et de type 2 sous schéma insulinique basal bolus par la TELEmédecine; abbreviated TELESAGE), conducted in a larger population of diabetic patients with poorly controlled basal-bolus insulin levels.

METHODS

TELESAGE is a multicenter, double-randomized, open-label, three parallel–arms study, conducted in approximately 100 centers in France. The study will compare a control group (arm 1: usual follow-up) with two DIABEO telemedicine systems: (1) physician-assisted telemedicine (arm 2), and (2) nurse-assisted telemonitoring and teleconsultations by a diabetologist’s task delegation (arm 3). Initial randomization will allocate the study arms in 12 French regions. A second randomization will assign patients in the groups allocated to each studied region. The primary objective of TELESAGE will be to investigate the effect of the DIABEO telemedicine system versus usual follow-up, with respect to improvements in the glycated hemoglobin levels of approximately 696 diabetic patients with poorly controlled basal-bolus insulin levels.

RESULTS

The TELESAGE study is sponsored by Sanofi (Gentilly, France). A primary completion date is expected in June 2018, and publication of results is expected within 6 months of work completion.

CONCLUSIONS

The TELESAGE study is expected to confirm the previous results of the TELEDIAB 1 study using a larger sample of diabetic patients. It is also expected to evaluate a nurse-assisted telemonitoring system. We will assess the potential of the DIABEO telemedicine service in terms of its utility and explore whether it can become an integral part of diabetes care for patients.

CLINICALTRIAL

ClinicalTrials.gov NCT02287532; https://clinicaltrials.gov/ct2/show/NCT02287532 (Archived by WebCite at http://www.webcitation.org/6ykajhJKd)
Novel Approach to Cluster Patient-Generated Data Into Actionable Topics: Case Study of a Web-Based Breast Cancer Forum (Preprint)
Authors: Jones Josette , Pradhan Meeta , Hosseini Masoud , Kulanthaivel Anand , Hosseini Mahmood
Published: October 2017

BACKGROUND

The increasing use of social media and mHealth apps has generated new opportunities for health care consumers to share information about their health and well-being. Information shared through social media contains not only medical information but also valuable information about how the survivors manage disease and recovery in the context of daily life.

OBJECTIVE

The objective of this study was to determine the feasibility of acquiring and modeling the topics of a major online breast cancer support forum. Breast cancer patient support forums were selected to discover the hidden, less obvious aspects of disease management and recovery.

METHODS

First, manual topic categorization was performed using qualitative content analysis (QCA) of each individual forum board. Second, we requested permission from the Breastcancer.org Community for a more in-depth analysis of the postings. Topic modeling was then performed using open source software Machine Learning Language Toolkit, followed by multiple linear regression (MLR) analysis to detect highly correlated topics among the different website forums.

RESULTS

QCA of the forums resulted in 20 categories of user discussion. The final topic model organized >4 million postings into 30 manageable topics. Using qualitative analysis of the topic models and statistical analysis, we grouped these 30 topics into 4 distinct clusters with similarity scores of ≥0.80; these clusters were labeled Symptoms & Diagnosis, Treatment, Financial, and Family & Friends. A clinician review confirmed the clinical significance of the topic clusters, allowing for future detection of actionable items within social media postings. To identify the most significant topics across individual forums, MLR demonstrated that 6 topics—based on the Akaike information criterion values ranging from −642.75 to −412.32—were statistically significant.

CONCLUSIONS

The developed method provides an insight into the areas of interest and concern, including those not ascertainable in the clinic. Such topics included support from lay and professional caregivers and late side effects of therapy that consumers discuss in social media and may be of interest to clinicians. The developed methods and results indicate the potential of social media to inform the clinical workflow with regards to the impact of recovery on daily life.
BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES OF TRADITIONAL SIDDHA FORMULATION ON CCL4 INDUCED LIVER FIBROSIS IN RATS
Authors: Manickam Diwakar , Ramamoorthy Sri Kamatchi Priya , Kumar B. Santhosh , Subramaniam Samu , Subramaniam Shyama
Published: October 2017

ABSTRACTObjective:The main objective of this study is to evaluate therapeutic activity of traditional siddha formulation on CCl4 induced liver fibrosis in rats.Methods:Plant materials collected, shade dried, mixed equal proportion. This mixture was used for extract or kasayam preparation. Twenty four male Wistar albino rats were randomly divided into four groups of six rats each. The normal control group was allowed free access to food and water. Drug control group was allowed to daily intragastric administration of traditional siddha formulation 400mg per kg b.wt per day. Liver damage was performed in the remaining two groups with an i.p.injection of a 1.0 mL/kg b.wt CCl4 and olive oil (2:3 v/v) mixture, twice weekly for 8 weeks. All rats, with the exception of the injury model group, were intragastrically administered traditional siddha formulation (TSF) dosage 400 mg/ kg b.wt /day from 5th week to end of experiment of CCl4 intoxicated rats. The serum levels of hepatic markers and hydroxyproline (Hyp) in the rat livers were measured. Histopathological changes in the liver were assessed for each group using H&E staining and Masson Trichrome examination.Results:Traditional siddha formulation significantly reverse the liver function in CCl4 intoxicated rats correlate with both biochemical and histopathological changesConclusion:Traditional siddha formulation a promising drug for treating liver fibrosis.Keywords: Traditional siddha formulation, Liver fibrosis, CCl4 and Vaithiyars
THE EFFECTS OF OLIVE LEAF EXTRACT OINTMENT ON PAIN INTENSITY AND EARLY MATERNAL COMPLICATIONS IN PRIMIPAROUS WOMEN
Authors: Kaviani Maasumeh , Sepasi Sara , Azima Sara , Emamghoreishi Masoumeh , Asadi Nasrin , Haghpanah Sezaneh
Published: October 2017

Objective: This study aimed to assess the impact of olive leaf extract ointment on pain intensity and early maternal complications in primiparous women.Methods: This randomized clinical trial was conducted on 90 primiparous women. The participants were randomly divided into three groups each containing 30 women. Groups A, B, and C used olive leaf extract ointment, placebo ointment, and betadine solution at the episiotomy area three times a day for 10 d. Improvement of the episiotomy wound was evaluated using REEDA scale, and pain intensity were assessed through Visual Analogue Scale (VAS). The evaluations were performed 4 h and 3, 7, 10, and 14 d after delivery.Results: The results showed a significant difference between the olive leaf extract ointment group and the other groups regarding the improvement of episiotomy wound (p<0.001). Pain intensity also significantly was reduced in this groups 10 d after delivery (p=0.029).Conclusion: Olive leaf extract ointment was relatively effective in reduction of pain intensity and early maternal complications resulting from an episiotomy.
PHENYLPROPANOIDS AND FATTY ACIDS LEVELS IN ROOTS AND LEAVES OF DATURA STRAMONIUM AND DATURA INNOXIA
Authors: Rahmoune Bilal , Zerrouk Izzeddine Zakarya , Morsli Abdelkader , Slaoui Madjda Khelifi , Khelifi Lakhdar , Do Amarante Luciano
Published: October 2017

Objective: The aim of this research was to determine and compare phenylpropanoids and fatty acids composition in two plant species, Datura innoxia and Datura stramonium.Methods: Phenylpropanoids and fatty acids composition in leaves and roots extracted from Datura innoxia and Datura stramonium, grown under greenhouse conditions, was analyzed by gas chromatography–electron impact/time of flight-mass spectrometry (GC-EI/TOF-MS) chromatography techniques. Analyses were carried out at the Max Planck Institute for Molecular Plant Physiology of Golm (Germany).Results: We revealed that Datura stramonium (DS) contains hydroxy-hexanedioic acid while hexanoic acid was found in Datura innoxia (DI). Also, two fatty acids are common to both Datura species, hexadecanoic acid and octadecanoic acid, with an almost equal rate between leaves and roots. However, phenylpropanoids composition revealed eight compounds; luteolin, quercetin, trans-caffeic acid, trans-ferulic acid, cis-caffeic acid, cis-4-hydroxy-cinnamic acid, trans-4-hydroxy-cinnamic acid and trans-sinapic acid in DI. However, in DS, five compounds were detected: luteolin, quercetin, trans-caffeic acid, trans-ferulic acid and dihydroferulic acid. Also in both Datura species, phenylpropanoids concentration in leaves was significantly higher than in the roots.Conclusion: Our results showed a difference in phenylpropanoids and fatty acids compositions between the two Datura species, with a significantly higher concentration of phenylpropanoids in Datura innoxia than in Datura stramonium
ACUTE TOXICITY EVALUATION OF ETHANOLIC EXTRACT OF ARISTOLOCHIA ALBIDA DUCH. LEAVES ON WISTAR RATS LIVER AND KIDNEY FUNCTIONS
Authors: Guinnin Felix F. D. , Klotoe Jean Robert , Ategbo Jean Marc
Published: October 2017

Objective: Aristolochia albida Duch is frequently used by alternative medicine to treat some pathologies like hepatitis. Our main objective was to evaluate the acute oral toxicity of the ethanolic extract of this plant.Methods: Exploratory tests for acute oral toxicity are performed in vivo on Wistar albino rats in a limit test of 2000 mg/kg for 14 d in accordance with the OECD Guidelines 423. The clinical signs were observed every day, followed by measurement of body weight change, the haematological and biochemical examinations were executed and statistical analysis was performed. Results: The various clinical signs observed after administration and for 14 d were recorded and no mortality was observed. With the exception of white blood cells, mean cell volume and platelets with statistically significant difference in control (p<0.05), all the haematological parameters showed an insignificant statistical difference to the control ratio (p>0.05). For biochemical parameters, except blood glucose and total protein of control batches, which show a significant statistical difference after 14 d (p>0.05), all the biochemical parameters show the statistically insignificant difference for test and controls batches (p>0.05) as well as the weight variation of the animals.Conclusion: The ethanolic extract of the leaves of A. albida Duch (EEAr) had not toxic effect on the biochemical and hematological parameters studied at a dose of 2000 mg/kg. The lethal dose is therefore over 2000 mg/kg.
ANTIBIOTIC USE AT PRIMARY HEALTHCARE CENTERS IN SURABAYA: A SURVEILLANCE STUDY
Authors: Herawati Fauna , Hartono Ivan D. , Pranajaya Dicky , Narindra I. Putu Hendryx
Published: October 2017

Objective: Antibiotics are considered to be overprescribed in primary health care centers. This study aimed to investigate the defined daily dose (DDD) of antibiotics per 1000 patients visit in a year in primary health care centers, the prevalence of upper respiratory infections (URI) and diarrhea, the percentage of antibiotic prescription for URI and diarrhea in Surabaya.Methods: A surveillance study of antibiotic use was done from the reports and use of drug demand sheet, which called laporan pemakaian dan lembar permintaan obat (LPLPO), outpatient medication card, and health care information and management system of primary health care center, which called sistem informasi manajemen manajemen puskesmas (SIMPUS) in Surabaya. DDD/1000 patients were calculated for describing the antibiotics usage level in each primary health care centers. Three primary health care centers selected based on its antibiotic use or its population density to recognize its antibiotic prescribing percentage for non-pneumonia respiratory tract infection and nonspecific diarrhea.Results: The DDD antibiotic systemic per 1000 patients visit primary health care centers in Surabaya is relatively low. The results found higher prevalence URI does not correlate to the frequent antibiotic prescribed. The prevalence of URI at one primary healthcare center (25% cases) was less than at the other (44%), but the percentage of antibiotic prescription and the total antibiotic usage were higher (73%; 1006 DDD/1000 patients vs. 21%; 675 DDD/1000 patients). The prevalence of diarrhea at primary health care center 2 (2,84%) was less than at primary health care center 1 (4,95%), but the percentage antibiotic prescription and the total antibiotic usage were higher (43%; 1006 DDD/1000 patients vs 18%; 675 DDD/1000 patients).Conclusion: The antibiotic usage at primary healthcare centers in Surabaya was shown to vary widely. Eighty-seven percent (55/63) primary health care centers antibiotic usage was less than 4 DDD/1000 patients day, only two primary health care centers antibiotic usage 6 DDD/1000 patients day. Further research to investigate antibiotic usage and the differences in usage between primary health care centers in treating URI is required.
ANTIDYSLIPIDEMIA AND ANTIOXIDANT ACTIVITY OF ANDROGRAPHOLIDE COMPOUND FROM SAMBILOTO (ANDROGRAPHIS PANICULATA) HERB
Authors: Warditiani Ni Kadek , Susanti Ni Made Pitri , Arisanti Cokorda Istri Sri , Putri Ni Putu Rika Dharma , Wirasuta I Made Agus Gelgel
Published: October 2017

Objective: The aim of this study was to observe the antidyslipidemic and antioxidant activity of andrographolide (AND) compound from Sambiloto (Andrographis paniculata) herb. The antidyslipidemic activity could be described by lowering TC (total cholesterol), TG (triglyceride), and LDL (low-density lipoprotein) level in the blood and by increasing HDL (high-density lipoprotein) level in the blood. The antioxidant activity could be described by inhibiting the ox-LDL (oxidized low-density lipoprotein) formation.Methods: AND was separated from the sambiloto ethanolic extract. Atherosclerosis in rats was induced by rich fat food (5% yolk, 10% lard), 1% calcium and 20.000 IU vitamin D3 for 90 d. The rats were treated with AND compound on the 61st day for 30 d. On the 90th day, the blood of rats had been collected, and its blood vessel was also extracted. Antidyslipidemic activity was measured by estimating the level of TC, TG, LDL and HDL in the blood. Antioxidant activity was measured by calculating the ox-LDL concentration in blood and histopathology parameter.Results: 18 mg/kg BW AND could reduce the level TC, TG, and LDL in blood, and could increase HDL blood level significantly (p<0.05). This compound can also significantly inhibit LDL oxidation (p<0.05), and the histopathology result showed that this compound could protect the vessel from adhesive lipid plaques.Conclusion: AND compound from sambiloto herb showed the antidyslipidemic and antioxidant effect in atherogenic rats.
EFFECTIVENESS OF SPIRULINA MOUTHWASH ON REDUCTION OF DENTAL PLAQUE AND GINGIVITIS: A CLINICAL STUDY
Authors: Maniyar Radhika , K. Umashankar G.
Published: October 2017

Objective: The present study evaluated the effectiveness of Spirulina mouthwash on the reduction of dental plaque and gingivitis.Methods: A single-blind clinical trial was conducted among thirty patient’s aged 18-40 y visiting dental college and hospital in Bangalore city. Mouthwash was prepared using 0.5% Spirulina. Intervention protocol consisted of instructing the patients to rinse with 10 ml of mouthwash for 1 minute twice daily for 7 d. Plaque index and Gingival index were used to assess the variables at the baseline and after the intervention. The perception of the individual subjects with regard to the use of mouthwash was assessed using 10 cm long visual analog scale (VAS). Statistical analysis was carried out using Wilcoxon signed rank test for mean pre and post plaque and gingival scores respectively. Descriptive statistics was performed for VAS questionnaireResults: The results showed a highly significant difference (p<0.001) between the mean plaque scores at the baseline (2.16±0.34) and at the follow up (1.27±0.46). The mean gingival scores at the baseline (1.86±0.38) and at the follow-up (1.05±0.43) also showed a highly significant difference (p<0.001). Regarding the Visual Analog Scale, the mean values of 5 or greater than suggested the responses to be favourable as the values were reflectedConclusion: The study showed that Spirulina mouthwash resulted in significant reduction in dental plaque and gingivitis. Also, the mouthwash was convenient to use without any adverse effects. Hence, the use of herbal mouth rinses such as Spirulina should be supported.
THE RELATION BETWEEN INTERNET, DEPRESSION, SELF-ESTEEM AND SOCIAL ATTACHMENT ON COGNITIVE FUNCTION OF HEALTH CARE INDIVIDUALS
Authors: Ramasubramanian Vikhram , Venkataraman Rajesh , Pandian Raja Soundara , Teli Gopal , Shrestha Niraj
Published: October 2017

Objective: To assess the internet use in health care individuals and its impact on depression, self-esteem and social attachment on cognitive function of health care individuals.Methods: This was a cross-sectional survey which included one hundred and ten healthcare individuals (Physician, Pharmacist, Psychologist, Social worker and Nurses) in this study conducted in Radianz healthcare and research private limited. Young’s internet addiction test and depression score, self-esteem (Rosenberg’s) score and MoCA were used to measure internet addiction and psychological variables. EPI 2012 was used for statistical analysis.Results: Out of 110 individuals, the majority of individuals, depressed individual were more addicted to the internet and found to be significant by using depression score. Relationship between baseline values and follow up values in internet addiction was significant (P=0.07636). After follow up the internet addiction found to be reduced as it was greatly affected in initial survey.Conclusion: This study concluded that there is relationship between the internet addiction and depression, cognitive function and self-steam. The depressed individuals were more addicted to the internet followed by abnormal cognitive function and low self-esteem individuals. Internet addiction may be a relevant clinical construct and early diagnostic tools that needs extensive research even in developing nations to explore the relationship. Depression is greatly associated with the internet addiction so if can we reduce the depression then can be reduced internet addiction.
Internalisasi Nilai Melalui Student Centered Learning (SCL) Approach
Authors: Zulfatmi Zulfatmi
Published: October 2017

The learning process that takes place in educational institutions such as schools and even universities are still dry from the effort of planting value for learners. The process that lasted more dominated by the transfer of knowledge (of pouring knowledge) instead of internalizing the values that are important matters in an educational activity. Meanwhile, adult learning methodology has evolved so rapidly, so there has been a learning paradigm shift from teacher-centered learning centered on the learner. As these changes raised concerns some educators to the growing dryness of the learning process of internalization efforts on students in various educational institutions. This study seeks to present a common thread among the various concerns, efforts to internalize the value in educational practice on the one hand and the spirit of the implementation of learning approach centered on the learner on the other side.
Continuity in Community Medicine Training
Authors: Bernstein Rebecca , Ruffalo Leslie , Morzinski Jeffrey , Nelson David , Ahmed Syed , Seehusen Dean A.
Published: October 2017

Background and Objectives: Family medicine residency training emphasizes the importance of community medicine. Recent scholarship has helped to identify important elements of community partnerships, including bidirectionality and continuity. Given the importance of continuity in family medicine and community partnerships, this study explores the relationship between continuity in community medicine curricula, partnership quality, and residents’ community medicine competency. 
Methods: Survey questions were included in the 2015-2016 Council of Academic Family Medicine Educational Research Alliance (CERA) Family Medicine Program Director survey that probed community medicine curricular structures, partnership quality, and outgoing resident competency in community medicine. Multivariate logistic regression was used to test the impact of continuity on the outcomes of partnership quality and residents’ community medicine competency.
Results: Respondents represented 227 of 461 family medicine programs (49%). Block rotation, used in 150 (66%) programs, was the approach most commonly used to deliver community medicine curriculum. Eighty-five (45%) programs self-reported high quality partnerships and about one-third described outgoing residents as highly proficient in community medicine competencies. Program-level continuity in community partnerships was significantly correlated to high quality partnerships (odds ratio [OR] 3.51, 95% confidence interval [CI] 1.79-6.89, P<0.001) and educational outcomes (OR 2.85, 95% CI 1.38-5.89, P=0.005), while resident-level continuity was not.
Conclusions: Our findings support the importance of continuity to the quality of family medicine residency community partnerships as well as resident education in community medicine. Further research is needed to understand the importance of continuity at the program level versus individual resident level.
Years of sound living: Mikser festival in Savamala (2012-2016)
Authors: Medic Ivana
Published: October 2017

This article deals with the soundscape of Mikser, an independent festival of
contemporary creativity, established in 2009 in Belgrade, the capital city of
Serbia. I focus on the years 2012-2016, during which Mikser was taking place
in Savamala, an urban quarter in central Belgrade - which itself has
undergone various urbanistic and cultural transformations in recent years.
The creative team behind Mikser aimed to turn Savamala into a permanent
fixture on the map of Belgrade nightlife and a tourist hotspot; the fact that
they did not succeed was on account both of financial issues and conflicting
top-down business interests. My conclusion is that the long-term survival of
the festival is not dependent on its program or audiences, but on securing
official support and infrastructure.
Dragutin Gostuski and the semiotics of music
Authors: Tomasevic Katarina
Published: October 2017

The main goals of this article, devoted to the contribution of the prominent
Serbian musicologist, composer and aesthetician Dragutin Gostuski (1923-1998)
to the semiotics of music, are the following: 1) to show the evolution of
semiotic ideas in Gostuski?s work; 2) to reconstruct the circumstances under
which preparations for the First International Colloquium on the Semiotics of
Music took place; and 3) to encourage new research that would re-examine
Gostuski?s major theoretical opus in the historical context of the
discipline.
Dr Karol Kiko - Slovak u Srpskom Kovinu
Authors: Nikolic Slobodan , Zivkovic Vladimir
Published: October 2017

nema
Embolizations of the hepatic tumors - two-year single center experience
Authors: Janczak Dariusz , Zielińska Dorota , Pawełczyk Jerzy , Dorobisz Tadeusz , Garcarek Jerzy , Patrzałek Dariusz , Chabowski Mariusz
Published: October 2017

Background/Aim. Transcatheter arterial chemoembolization (TACE) and portal vein embolizations (PVE) are established methods of treatment of patients with hepatic tumors. The aim of the study was to present our experience in the treatment of liver tumors with embolization as a preliminary treatment for surgery or a part of palliative treatment. Methods. The analysis included 29 patients who had undergone 34 embolizations. Results. TACE was performed in 26 cases with hemangiomas in the unfavorable location, or mass effect and inoperable malignant tumors both primary and metastatic. PVE was performed in 8 cases with primary liver tumors and colon liver metastases.All included patients presented inoperable hepatic tumors. TACE was carried out in the patients with hepatocellular carcinoma (n = 1), cholangiocarcinoma (n = 1), metastatic tumor (n = 8), and hemangioma (n = 16), while PVE in the patients with cholangiocarcinoma (n = 2), metastatic tumor (n = 5) and neuroendocrine tumor (n = 1). The embolization was followed by surgery in the 5 PVE patients and 6 TACE patients. The postembolization syndrome was observed in 7 subjects. Death due to cancer progression occurred in the 4 PVE patients and 7 TACE patients. One patient died during TACE due to hemorrhagic shock. Conclusions. Right PVE and selective TACE are efficient for preliminary preparation of patients with healthy hepatic parenchyma for major liver resections, but the patients with liver cirrhosis require careful assessment. In the patients with hemangioma, embolization allows to avoid surgical treatment by reducing the lesion mass, or the extent of hepatic resection. The preliminary results of arterial embolizations with bleomycin, leading to tumor reduction in cases of giant liver hemangiomas are promising.
Identifikasi Motif Batik Tulis Klampar Madura Dalam Perlindungan Hak Cipta
Authors: Lodra I Nyoman , Mariasa Nengah , Hardayaningrum Warih
Published: October 2017

Motif batik tulis desa Klampar Pemekasan Madura memiliki keunikan, kekhasan, dan kebaharuan (novelty). Agar motif-motif batik tulis tersebut tidak di klaim oleh daerah lain dan bangsa asing perlu dilindungi dengan Hak Cipta. Terkait dengan hal tersebut ada tiga permasalahan seperti berikut.1) untuk mengidentifikasi motif batik tulis Klampar, Madura (2) untuk mengetahui mengapa perlu dilindung dengan Hak Cipta 3) untuk mengetahui bentuk perlindungan motif batik tulis Klampar Madura. Tujuannya dilakukan penelitian: 1) Dapat mengetahui identitas dan karakteristik motif batik tulis Klampar Madura. 2) Agar motif batik tulis Klampar Madura tidak di klaim daerah lain atau bangsa asing.3) Dapat diketahui jenis perlindungan motif batik tulis Klampar Madura. Manfaatnya: 1) Diketahui identitas motif batik tulis Klampar Madura. (2) Agar motif batik tulis Klampar Madura tidak bisa di klaim oleh daerah lain atau bangsa asing. 3) Adanya perlindungan motif batik tulis Klampar, Madura, memiliki nilai ekonomi dan moral. Teori pembedah permasalahan dengan teorianalisis, dekonstruksi, dan etnografi.Metode penelitian deskriptif kulitatif, dengan pendekatan yuridis emperis.Pengumpulan data, observasi, wawancara, dan dokumen, serta desain penelitian mulai pengumpulan data, pengolahan data, analisis data, penyusunan laporan. Temuan penelitian; penciptaan motif batik tulis dilandasi karakteristik dan filosofi hidup masyarakat dengan pendekatan stilisasi, asimilasi, dan adaftasi. Menghasilkan produk berupa buku “database”.
Model Pembelajaran Financial Literacy untuk Meningkatkan Karakter Wirausaha Bagi Lulusan Sekolah Menengah Kejuruan
Authors: Kardoyo Kardoyo , Widiyanto Widiyanto , Thomas Partono , Setiaji Khasan
Published: October 2017

Membangun karakteristik wirausaha bagi lulusan sekolah menengah kejuruan (SMK) merupakan suatu keharusan, karena lulusan diharapkan dapat menjadi wirusahawan yang mandiri, dimana hal ini sesuai dengan tujuan diselenggarakannya sekolah menengah kejuruan. Selama ini pembelajaran wirausaha lebih banyak diarahkan pada penumbuhan semangat dan sektor pemasaran, sedangkan sisi dalam mengelola keuangan masih belum banyak disentuh. Sehingga pengelolaan keuangan yang diperoleh masih belum mampu untuk mendukung kesuksesannya dalam berwirausaha. Penelitian ini bertujuan untuk mencari tahu tentang pemahaman siswa dalam masalah keuangan dan sejauh mana mereka mampu mengelola keuangan, dengan target utama menyusun model pembelajaran financial literacy untuk SMK. Penelitian ini memiliki urgensi pada siswa dalam memahami keuangan sebagai darah dalam wirausaha, dan melek keuangan (financial literacy) akan memperkuat karakter seseorang dalam berwirausaha, bagi guru dan pengajar lainnya akan memberikan model dan materi dalam pembelajaran financial literacy.
Analisis Faktor Internal Perusahaan Yang Mempengaruhi Audit Delay
Authors: Kopong Libu Beda Trifortuna , Muskanan Moni W
Published: October 2017

Penelitian ini bertujuan untuk menganalisis pengaruh laba/rugi, kompleksitas operasi perusahaan, ukuran perusahaan, dan umur perusahaan terhadap audit delay pada perusahaan property dan real estate yang terdaftar di Bursa Efek Indonesia tahun 2011-2015. Penelitian ini menggunakan pendekatan kuantitatif. Sampel dalam penelitian ini diperoleh dengan menggunakan metode purposive sampling. Berdasarkan kriteria yang ditetapkan, didapatkan 6 perusahaan property dan real estate yang menjadi sampel dalam penelitian ini. Teknik analisis data yang digunakan adalah analisis regersi linear berganda. Hasil pengujian signifikansi parameter individual (uji t) menunjukkan bahwa variabel laba/rugi berpengaruh terhadap audit delay, sedangkan kompleksitas operasi perusahaan, ukuran perusahaan dan umur perusahaan tidak mempunyai pegaruh terhadap audit delay. Hasil pengujian signifikansi simultan (uji F) menunjukkan bahwa keempat variabel independen secara bersama-sama berpengaruh terhadap audit delay pada perusahaan property dan real estate yang terdaftar di Bursa Efek Indonesia tahun 2011-2015
IMPLEMENTASI PROGRAM SERTIFIKASI GURU DALAM JABATAN (STUDI PADA MADRASAH ALIYAH NEGERI CIPARAY KABUPATEN BANDUNG)
Authors: Yusuf Ningrum Fauziah , Bekti Herijanto , Sukarno Dedi
Published: October 2017

Menyadari akan pentingnya peranan pendidikan dalam meningkatkan kualitas sumber daya manusia, pemerintah berupaya untuk meningkatkan kualitas guru melaksanakan sebuah program sertifikasi guru. Tujuan penelitian ini ialah untuk mengetahui bagaimana proses implementasi program sertifikasi guru untuk guru madrasah yang dilakukan oleh Kementerian Agama Kabupaten Bandung. Teori yang digunakan dalam penelitian ini adalah teori implementasi program menurut Charles O. Jones yang menyebutkan tiga aktivitas dasar yaitu organisasi, interpretasi, dan aplikasi. Metode penelitian yang digunakan adalah kualitatif deskriptif dengan teknik penentuan informan menggunakan teknik purposive. Hasil penelitian menunjukan bahwa implementasi program sertifikasi guru dalam jabatan khususnya pada guru Madrasah Aliyah Negeri Ciparay yang dilakukan oleh Kementerian Agama Kabupaten Bandung pada pelaksanaannya belum optimal karena masih terdapat beberapa kendala yang dihadapi. Dilihat dari organisasi masih kurangnya sumber daya manusia dan sumber daya finansial yang tersedia. Dari aspek interpretasi, para pelaksana program sudah memahami tujuan dan pedoman program akan tetapi dalam pelaksanaan tugas dan fungsinya masih belum konsisten. Dalam aspek aplikasi, ditemukan pengawasan pada pelaksanaan program tidak berjalan, terlihat pada belum adanya laporan evaluasi untuk pelaksanaan program sertifikasi guru dalam jabatan yang telah dilaksanakan pada tahun-tahun sebelumnya. ABSTRACT Recognizing the importance of the role of education in improving the quality of human resources, the government seeks to improve the quality of teachers to implement a teacher certification program. The purpose of this study was to find out how the process of implementation of the teacher certification program for madrasah teachers conducted by Kementerian Agama District Bandung. The theory used in this research is the theory of program implementation by Charles O. Jones who cites three basic activities, namely the organization, interpretation, and application. The method used is descriptive qualitative determination techniques informants usingtechnique. purposive sampling. The results showed that the implementation of certification of teachers, especially teachers of Madrasah Aliyah Negeri Ciparay conducted by Kementerian Agama District Bandung not optimal because there are still some obstacles encountered. Judging from organizations still lack the human resources and financial resources available. From the aspect of interpretation, all program managers have understood the objectives and guidelines for the program but in the implementation of tasks and functions are still not consistent. In the aspect of the application, found the supervision of the implementation of the program is not running, is seen in the absence of an evaluation report on the implementation of in-service teacher certification program that has been implemented in previous year.