bluuebunny/crossref_metadata_2025 huggingface dataset:
College Students’ Perceptions of Stress and Coping Mechanisms
Authors: Gallagher Kelsey M. , Jones Tiara R. , Landrosh Nicole V. , Abraham Samuel P. , Gillum Deborah R.
Published: June 2019

Background: Typical college students experience stressors every day. Purpose: The purpose of this study was to determine college students’ perceptions of stress and coping mechanisms. Method: A quantitative, non-experimental, cross-sectional, descriptive research design was used to assess students’ perception of stress and coping mechanisms. To collect data, a survey tool was used to answer 6 demographic and twenty-five survey items on a 4-point Likert-type scale. Two central research questions guided the study: (1) What are college students’ perceptions of stress? and (2) What are college students’ perceptions of coping mechanisms? Results: The responses to these questions were analyzed and the implications are discussed. Conclusion: College students agree that college life is stressful and that their level of stress increases significantly before exams. In addition, students reported that expectations to excel in classes cause additional stress. Students reported a variety of coping mechanisms, including listening to music, socializing with friends/family, and sitting alone in a quiet place.
PyNTA: An Open Source Software Application for Live Particle Tracking
Authors: Faez Sanli , Carattino Aquiles , Mosk Allard
Published: June 2019

We introduce PyNTA, a modular instrumentation software for live particle tracking. By using the multiprocessing library of Python and the distributed messaging library pyZMQ, PyNTA allows users to acquire images from a camera at close to maximum readout bandwidth while simultaneously performing computations on each image on a separate processing unit. This publisher/subscriber pattern generates a small overhead and leverages the multi-core capabilities of modern computers. We demonstrate capabilities of the PyNTA package on the featured application of nanoparticle tracking analysis. Real-time particle tracking on megapixel images at a rate of 50 Hz is presented. Reliable live tracking reduces the required storage capacity for particle tracking measurements by a factor of approximately 103, as compared with raw data storage, allowing for a virtually unlimited duration of measurements
Monitoring of Trace Gases over Antarctic by GaoFen-5/AIUS: Algorithm Description and First Retrieval Results of O3 , H2O and HCl
Authors: Li Xiaoying , Cheng Tianhai , Xu Jian , Shi Hailiang , Wang Pengmei , Zhang Xingying , Ge Shule , Wang Hongmei , Zhu Songyan , Miao Jing , Luo Qi
Published: June 2019

AIUS (Atmospheric Infrared Ultraspectral Sounder) is an infrared occultation spectrometer onboard the Chinese GaoFen-5 satellite, which covers a spectral range of 2.4--13.3 μm (750--4100 cm-1) with a spectral resolution of about 0.02 cm-1. AIUS was designed to measure and to study chemical processes of ozone (O3) and other trace gases in the upper troposphere and stratosphere over Antarctic. In this study, the corresponding retrieval methodology is described. The comparison between AIUS measurements and simulated spectra illustrates that AIUS measurements agree well to the simulated spectra. To first evaluate the reliability of our retrieval algorithm, three retrieval O3 experiments are performed based on ACE-FTS observation spectra. A comparison between our retrieved profiles and the ACE-FTS official products shows that the relative difference of these three retrieval experiments is mostly within 10% between 20 km and 70 km. These retrieval experiments demonstrate that the retrieval algorithm described in this study work fine and reliable. Furthermore, O3, H2O and HCl profiles are retrieved from eight orbits of AIUS measurements and compared with the official AURA/MLS level-2 v4.2 profiles. Comparison experiments show that the relative difference is mostly within 10% (about 0.02 - 0.4 ppm) between 18 and 58 km for O3 retrieval, within 10% (0-0.5 ppm) between 15 and 80 km for H2O retrieval, and within 10% (about 0.1 ppb) between 30 and 60 km for HCl retrieval. There is a good agreement in the retrieved trace gas profiles obtained from AIUS and from coincident profiles from MLS.
Diagnostic Imaging in Pediatric Chronic Rhinosinusitis: A Guide for Clinicians
Authors: Conte Giorgio , Caschera Luca , Magnani Sandro , Cinnante Claudia , Triulzi Fabio Maria , Pignataro Lorenzo , Torretta Sara
Published: June 2019

Pediatric rhinosinusitis are common encountered disorders caused by different pathogenic factors or predisposing conditions with a proportion of them progressing to chronicity with a meaningful impact on quality of life and related adverse effects. A deep understanding of pathophysiology, disease course and prognosis are the fundamental building block to an appropriate management of rhinosinusitis in order to avoid risks related to complications. This review gives concise answers to clinicians who want to know "when do we need imaging?" "what do we aspect from imaging?" and "what are the appropriate imaging modalities in different settings?” in pediatric patients in order to increase the appropriateness of imaging examinations.
Human respiratory system: designing student worksheet based on inquiry to promote 21st-century skills
Authors: Yusnaeni Y , Lika Angela G , Hiul Sriarmila
Published: June 2019

A student worksheet is one of the learning resources containing work intended for students to be more active in learning. A student worksheet is designed based - inquiry so that learning is more meaningful and student-centered. Investigation optimally involves all students' ability to search and investigate systematically, critically, logically, analytically, so that they can formulate their findings confidently. This study aims to produce student worksheet based - Inquiry with profiles and qualities that are feasible to use in classroom learning, developed by adapting the ADDIE model. The validity of the worksheet development results is measured from the result of validation by the expert validator, the quality, and practicality of the worksheet seen from the responses given by students and teachers. The data of the development results were analyzed descriptively qualitatively. The results showed that the worksheet based-Inquiry had fulfilled the three requirements for proper worksheet preparation that is didactic, constructive, and technical requirements. Student worksheet based-Inquiry declared very valid with an average value of 3.70 and is feasible to use. A student worksheet is also in a first category based on the responses of students and teachers with scores of 82.92% and 83.50%, respectively, so it is concluded feasible to be used in learning.
Basic Humor Techniques of Arthur A. Berger
Authors: Trifunović Vesna
Published: June 2019

The essay deals with basic techniques that can be detected in various humor genres, whose rationale is to generate amusement. A long list of basic humor techniques has come to attention as a result of problematising and analysis of different humor genres done by the American media professor Arthur A. Berger. A. Berger is by and large unknown to the Serbian scientific community, so the initial piece of the thesis is dedicated to the presentation of the aforementioned author and his body of work. What follows are the basic humor techniques that are perused through native yarns. Berger believes that the joke, due to its condensed form, is a particularly successful vehicle for illuminating the functioning of humor techniques, an explanation that is an integral part of the thesis. It is evident that not all techniques are helpful in the examination of jokes, which is why it was necessary, for a number of them, to divulge other humor genres. This fact, as indeed many others, has led to a critical reexamination of Berger's techniques and to analysis of how they could be further developed, modified and used in anthropological and folklore researcher, a matter that is dealt with in the conclusion. Basic humor techniques that are identified by Arthur A. Berger as containing great methodological potency that can be of significance in the analysis of different genres and narratives. As such, these techniques are certainly an admirable form from the standpoint of the effort that was put into their formation.
Defining Urban Legends
Authors: Hristić Ljubomir
Published: June 2019

Urban legends are friend-of-a-friend stories (FOAFS) that are told to describe strange, but supposedly real events, when in fact they are fictional through word of mouth invention or distortion. There is usually a true element to the legend, but it becomes fictional as it is passed from one person to the next. Core elements in most urban legends remain similar, but the details of the story can differ from one milieu to the next. In the following paper focus is brought upon the naming, and subsequent debates that emerged in this, par excellence folklore genre.
Legends of Organ Theft: The Moral Dilemma of Organ Donation
Authors: Antonijević Dragana
Published: June 2019

Legends and rumors of organ theft became a global phenomenon in the beginning of the 80s, with the information originating from the “third world” countries. Victims where poor and powerless, typically children. The rumor engaged a series of actions from anthropologists, NGO’s and media trying to ascertain their validity. Before long, the world was divided into two camps: on the one hand where those who believed the rumors, condemning the West for its exploitation of the underdeveloped and the poor that lead to organ theft from healthy individuals to satisfy the needs of the rich white patients: and the other faction that, through the data, tried to negate these assertions as unfounded and illogical. At the beginning of the nineties, similar reports surfaced in the highly developed societies of Europe and the US. Unlike the rumors, these where developed, structured narratives with specific content-legends of kidney theft, whose victims were left alive. Internet has brought about the expansion of such stories. None the less, they remained the under-analyzed, not attracting the attention of the politically minded and militant anthropologists who, in the third world rumors, recognized material for their anti-colonial and mediatory theories. Few have tried to explain the legend and folklore origins of the “first world” narratives and to ascertain their function without insightful analysis. That is why I engaged in a semantic analysis of the legend in the context of the highly developed societies, with the intent of exposing their message of a deep moral dilemma concerning organ donation. Their hidden meaning is an inversion of the public discourse that encourages voluntary and legal donations. The legend, in my view, sent an opposite message-showing the reverse side of the transplantation issue, medical progress and a deeper, existential dilemma of life and death, sickness and health, exposing the doubts intertwined with organ transplantation. Interestingly the legends of organ theft that appeared in Serbia during 2007 had more in common with the legends of the third world, than with the narratives of the developed societies. In the essay, the interposition of the legends from Serbia that were instigated by the transitional nature of its socioeconomic reality, are elaborated. That has inspired me to put forward a scheme of narrative, geographical and social transformation of the organ theft legends, thus showing their development intertwined with motifs and spatial markers disperses a system of performances around the world.
Who Murdered Joe Magarac?
Authors: Kovačević Ivan
Published: June 2019

In the paper the creation of the mythical hero of the American steel industry Joe magarac is analyzed. The analysis is based on the original text of Owen Francis from 1931 and it endeavors to resolve the quandary of whether this text is of a folklore or fakelore nature. The analysis is multi layered and is comprised from a parallel reading of the Francis text and the folklore elements from the migration country; confronting the meaning of the legend of Joe Magarac with authentic interests of workers in the steel industry and contextualizing the legend inside the social conflicts in the steel industry of Pennsylvania at the meeting point of the XIX and XX century.
Parental Curse as Invisible Violence: Тhe Discourse of Anti-Maternity in the Traditional Culture of the XIX Century
Authors: Radulović Lidija
Published: June 2019

Curse is an appellative genre, a clichéd verbal proverb that is uttered in belief, that with the assistance of supernatural forces, God or demon, through the magical properties of words, evil will come upon an individual. It is ex­amined through the context of the ideal motherhood discourse in the tradition culture of the XIX and the first half of the XX century, in view that it was perceived to be an idiosyncrasy of female demeanor. Maternity as a cultural construct in the traditional culture of Serbia is based upon the ideal mother­hood discourses as a gift from god, as an innate role for women, an inherent instinct for caring towards others, as an unconditional motherly love. In prac­tice, normative regulations and the concrete actions of a mother are not in complete concurrence, mothers love is not an objective fact, it can be present or not, vary in intensity, it can be selective, but it will depend on the personal history and cultural construct. Through such a focal point, motherly curse is perceived as a form of behavior that can be signified as anti-maternity. In the conceptualization of  a parental curse, from one viewpoint, the manner of usual behavior of women that has no real implications on the life of the child is legitimized, and on the other hand, it is believed that a mothers curse has the most potent magical effect and is delivered up to the ninth generation. Parental curse and the ritual of “cursing” do not include a black magic con­notation, and were considered a legitimate social mechanism through which evil was countered with evil i.e. the transgressor was being punished in cases where there existed no formal mechanism of punishment. Through such ac­tions, the community, or family are re-imposing order in the social relations, synchronously sending a message that reaffirms the correct matrix of behavior and moral values of the community.
Culture of reminiscing and the media narratives of the conflicts in Croatia
Authors: Vasiljević Jelena
Published: June 2019

In this paper I am analyzing the use of memories, inscribing images of the past and specific history interpretations present in Serbian and Croatian press published during the conflict in Croatia-period between 1991. and 1995.Although it is concerned with the media and the war in ex-Yugoslavia, the research presented here does not follow the known and many times formulated problem frame, which was conducted by all of these notions in order to demonstrate their perilous co-dependence-through the role and responsibility of the media in the latest Balkan wars. What I am searching for in this paper are conceptions about war (and wider topics, such as, conflict and its causes). I am interested in the ways war conceptualized itself through the process of transformation/shaping the information from the battlefields into narratives, stories which created war reality, by offering explanatory frame, protagonists, motives, causes and purposes. In that sense, I see the press as an ideal source for studying the production of daily narratives regarding the war, since it reported daily on it, offering various models for elucidating the war and its interpretation, reflecting public perceptions that dominated the society. The analyzed material are texts from Serbian and Croatian press that covered the war in the mentioned period of five years-starting from the first war skirmishes in Plitvice up to Croatian “Storm”. military operation, The essay is concerned with those texts that make images of the past topical and where collective memories appear as the shapers of the narratives, basis for understanding and self-understanding in the efforts of constructing a point of stability from which comprehending the reality would suggest/impose itself. From these texts we read different stories on war events which refer to history and pre-history in their explanations, bring suppressed emotions, old “truths” which were “proven” in the past and new ideas legitimized in it. They are displayed and analyzed with the idea of pointing to the correlation between the cultures of reminiscing, process of narration and conceptualizing the cognitive patterns for presenting (war) reality.
The Untamed “Shrew”: Managing Reproduction as Cultural Practice
Authors: Žikić Bojan
Published: June 2019

Managing reproduction as an appliance of Western family planning to the Third World mostly, could be subject of the anthropological inquiry by investigating the population policy, but also by supplying anthropological methods and expertise to the policy-makers. Basic social and cultural factors of human reproduction are discussed in the paper, with an accent on local contexts, when reviewing reproductive concepts and practices.
Governing the sense of belonging
Authors: Brković Čarna
Published: June 2019

The topic of this work is critical reconsideration of a cultural idea which is standardized by the highest political-legal document of the Republic of Serbia. I am starting from the assumption that if in the Constitution as a "founding legal and political document of a state", are incorporated concepts of human rights, and, particularly, the rights of the minorities (as set apart and protected), then a certain idea is standardized by it, i.e., a concept about what is Culture or what it should be. The analysis points out to three main problems which stem from writings about culture in the Constitution of the Republic of Serbia from 2006. Firstly, the concept of culture used in the Constitution is grounded in the aged anthropological idea of culture as a complete, homogenous, and authentic whole. This idea of culture carries a great potential for creating cultural conflicts. Secondly, the ways of managing cultural belonging are not carefully considered. The writers of the Constitution have not offered the mechanisms to resolve the potential cultural clashes in which all conflicted parties respect the constitutionally offered solutions. Thirdly, in the Constitution, theses of liberal and multicultural policy of identity are not carefully united. Combining the idea of free and equal citizens with the recognition of specific cultural rights of the minority’s demands developing a specific system for overcoming their contradictions. Such a system has not been offered by the Constitution.
The Same Risk, the Different Vulnerability? Social Environment as Risk-generating Factor in Injecting Drug Users and Sex Workers
Authors: Žikić Bojan
Published: June 2019

Social epidemiology of blood-borne diseases has been investigated in Belgrade sex workers and injecting drug users. The overall aim of the study was to reveal factors responsible for social epidemiological exposure and vulnerability of the members of those groups, and in this paper some outcomes are discussed, namely those which suggest a little bit different patterns of establishing such vulnerability for injecting drug users and sex workers respectively. It looks like the social environment plays much greater part in producing social epidemiological risk for the sex workers than for the injecting drug users. Factors stemming from the social environment responsible for production of the social epidemiological risk are far more beyond reach and control of the sex workers than it is so with the injecting drug users.
Psychometric properties of two adolescent depression scales in a colombian community sample: ADRS and RCADS -major depression
Authors: Romero-Acosta Kelly , Gómez-de-Regil Lizzette
Published: June 2019

La depresión puede presentarse a cualquier edad; sin embargo, cuando ocurre en etapas tempranas de la vida el pronóstico es menos favorable. La identificación y el tratamiento tempranos necesitan herramientas válidas y confiables para evaluar la depresión en niños y adolescentes. El presente estudio analizó, en una muestra comunitaria colombiana, las propiedades psicométricas de dos escalas breves de depresión, utilizando métodos de la Teoría Clásica de los Test: Escala de Valoración de Depresión Adolescente (ADRS) versión de auto-reporte y la Escala de Ansiedad y Depresión Infantil Revisada (RCADS)– Subescala de Depresión Mayor. El análisis de las dos escalas mostró correlaciones ítem-ítem e ítemescala, moderadas y significativas. La consistencia interna fue significativa y adecuada para ambas escalas, ADRS (0.67) y RCADS-Depresión Mayor (0.71). Para ADRS, dos factores explicaron 37.39% de la varianza, mientras que la soluciónde un solo factor explicó 25.99% de la varianza. Para RCADS-Depresión Mayor, dos factores explicaron el 41.81% de varianza y un factor único explicó 29.14%. La validez de constructo fue satisfactoria, ambas escalas mostraron correlaciones moderadas y significativas con el criterio convergente (KADS-11) y el criterio discriminante (RCADS-Ansiedad Generalizada); aunque más fuertes en el primer caso. Los resultados evidencian que ADRS y RCADS-Depresión Mayor son herramientas efectivas para la valoración de síntomas depresivos en niños y adolescentes.
INDICE
Authors: Ciencia y Desarrollo Revista
Published: June 2019

Indice de la tabla de contenidos.
Motivacion y conductas de liderazgo en una poblacion militar de Arequipa
Authors: Abarca Julio
Published: June 2019

El objetivo de la investigación fue relacionar la motivación para liderar y las conductas del líder, en población militar en Arequipa. Se evaluó a 36 Oficiales, 25 varones y 11 mujeres, con personal a cargo. Se utilizó el cuestionario de motivación para liderar y el cuestionario de conductas del líder. Los resultados obtenidos por el análisis estadístico muestran que sí existe una relación significativa entre la motivación para liderar y las conductas del líder, además, existen relaciones significativas entre la motivación intrínseca para liderar y las conductas orientadas hacia la tarea, así como entre la motivación social normativa para liderar y las conductas orientadas hacia el cambio, sin embargo, no se encontró relación significativa entre la motivación extrínseca para liderar y las conductas orientadas hacia las relaciones. Se enfatiza la necesidad de la mejora continua y revalorizar aún más el liderazgo como una herramienta de gestión estratégica en las organizaciones.
Polyolefin-Based Multilayer Packaging Material Modified by Ethylene Propylene Copolymer in Food Storage
Authors: Тверитникова Изабелла , Tveritnikova Izabella , Кирш Ирина , Kirsh Irina , Помогова Дарья , Pomogova Darya , Банникова Ольга , Bannikova Olga , Безнаева Ольга , Beznaeva Olga , Романова Валентина , Romanova Valentina
Published: June 2019

The research features a comprehensive study aimed at increasing the technological compatibility of multilayer packaging materials. The paper describes a recycling technology with the prospect of returning the resulting secondary raw materials to the production cycle. The research included the following tasks: to conduct a comprehensive study of polyolefin mixtures modified by ethylene propylene copolymer; to study the effect of the copolymer on the rheological and physicomechanical properties of polymer compositions; to propose a technology for the recycling of secondary polyolefin mixtures. The research involved the following methods: the capillary viscometry method was used to determine the rheological properties of polymer compositions; the tensile test method was employed to define the physicomechanical properties of the compositions; the pycnometric method was used to assess the density of the mixtures. The study featured such polymers as polyethylene, polypropylene, and ethylene-propylene copolymer, which was chosen as a link between the polymers. The authors obtained polymer compositions in various ratios of polyethylene, polypropylene, and ethylene-propylene copolymer: 70:30:0; 68.5:28.5:3; 65:25:10; 30:70:0; 28.5: 68.5: 3; 25:65:10. The article describes the process of modifying polyolefin compositions based on polyethylene and polypropylene by ethylene-propylene copolymer on a single-screw extruder. The authors defined the rheological properties and the deformation-strength characteristics of the polymer mixtures. Repeated processing proved to lead to a decrease in the physicomechanical properties of polyolefin mixtures, with the exception of compositions based on polyethylene and polypropylene in the ratio of 30:70, where the breaking stress increased. The number of processing cycles increased the melt flow rate of the mixtures. The proposed technology is meant for producing multilayer packaging materials using packaging waste in the middle layer for contact with food.
Physico-Chemical and Texture Properties of Gelatin-Free Jelly Desserts
Authors: Неповинных Наталия , Nepovinnykh Nataliya , Петрова Оксана , Petrova Oksana , Белова Нина , Belova Nina , Еганехзад Самира , Yeganehzad Samira
Published: June 2019

The research features the technological challenge of producing jelly desserts by replacing gelatin by non-starch polysaccharides of plant, bacterial, and algal origin (separately or in binary mixtures) in order to overcome religious and ethical constraints. The authors focused on the texture which is responsible for gel network formation of desserts. Hydrocolloids are widely used in many food formulations to improve quality attributes and shelf-life. The polysaccharides under analysis included alginate, pectin, iota-carrageenan, konjac glucomannan, xanthan, and guar gum, separately or in binary mixtures. The experiment made it possible to determine polysaccharides and their optimal concentrations (konjac glucomannan 0.4 % : xanthan gum 0.6 %; locust bean gum 0.2 % : xanthan gum 0.8 %; iota-carrageenan 0.4 %) as gelling agents for the production of desserts without gelatin. Formation of a gel network in desserts occurs as a result of a complex interaction of hydrocolloids, milk fat, and sugar. Structure formation of jelly desserts with polysaccharides occurs already at 18 ± 2°C in 20–40 minutes. In contrast, the structure formation of the control sample occurred at 4 ± 2°C in 2–3 hours. Sensory evaluation of the products was conducted by panellists according to the following criteria: taste, colour, consistency, aroma, and appearance. The paper also describes an analysis of texture indicators. The shelf-life was assessed according to moisture content and water activity as 24 hours at 4 ± 2°C. Several economically-viable new formulations were identified: they successfully reproduced the essential attributes of well-established and widely-consumed traditional gelatin desserts.
Winter Buckwheat Grain: The Dynamic Pattern of the Mechanical Properties of the Main Fraction
Authors: Марьин Василий , Mar'in Vasily , Верещагин Александр , Vereshchagin Alexander , Бычин Николай , Bychin Nicolay
Published: June 2019

As quality requirements get lower and lower, the quality of buckwheat grain meant for buckwheat groats is deteriorating. The most typical example is winter buckwheat grain. Buckwheat grain has to be sorted according to various fractions before scouring. Thus, the mechanical properties of these fractions remain a relevant field of study. The research features the dynamic pattern in the mechanical properties of the main fractions of winter buckwheat grain according to fraction before and after storage. The research subject is fractions of buckwheat sorted according to grain size before scouring. The buckwheat grain was harvested in the foothills of the Altai Territory in May 2015; it meets the necessary standards. There were twelve samples: six samples were harvested and sent for recycling (May 2015); other six samples were stored for eight months up to March 2016. The buckwheat did not pass the temperature treatment stage. The smaller fractions revealed a greater deformation before and after storage. That can lead to a higher deformation rate during scouring. Thus, the changes in the mechanical properties of winter buckwheat grain occur differently for each fraction.
Automatic calibration and selection of optimal performance criterion of a water quality model for a river controlled by total maximum daily load (TMDL)
Authors: Cho Jae Heon , Lee Jong Ho
Published: June 2019

When manually calibrating water quality models, considerable time and attention are required. Hence, developing an automated model that allows for efficient and objective automatic calibration is highly desirable. The QUAL2Kw model calibrates the QUAL2K automatically using a genetic algorithm (GA). This study analyzes auto-calibration results and selects the optimal criterion for each objective function from six performance criteria. Additionally, a multi-objective auto-calibration was conducted using two kinds of performance statistics as the objective function of the GA. The auto-calibration model was applied to the Yeongsan River and the total maximum daily load (TMDL) was established to achieve water quality goals at specific target points of this river. Among the six auto-calibration results based on a single performance criterion, Nash-Sutcliffe model efficiency (NSE) was the best criterion for calculating fitness through auto-calibration. To consider the calibration accuracies of the TMDL target points and the entire river simultaneously, an objective function using multiple performance criteria, specifically the weighted average of the normalized root mean squares error (CV(RMSE)) and the ratio of the RMSE to the standard deviation of the observed data (the RSR), was selected as the final auto-calibration of the model. The model calibration performance was good across the whole region as well as at the target points.
Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents
Authors: Faizi Shaheen , Sarfaraz Tahira , Sumbul Saima , Jabeen Almas , Halim Sobia A. , Mesaik Mohammad A. , Ul-Haq Zaheer
Published: June 2019

Background:

In continuation of our work on Mannich reaction on 8-hydroxyquinoline, fifteen different combinations of aromatic aldehydes and aniline were subjected to Mannich reaction from which twelve products (eight Mannich bases, two imines and two intramolecularly cyclized products with benzofuranone skeleton) were obtained. Among them six compounds (1, 2, 6, 8, 9 and 12) are the new compounds. The structures of the compounds were characterized by UV, IR, MS and 1H NMR.

Method:

The compounds were tested for the inhibition of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β) at a concentration of 25 µg/mL. The cytokines were produced by THP-1 cells differentiated with PMA for 24hrs and stimulated with LPS for 4 hrs and supernatant were analyzed through ELISA technique.

Results and Discussion:

Compounds 1-5, 8 and 9 inhibited the production of TNF-α and IL-1β. Compounds 1, 3, and 8 exerted potent inhibitions of TNF-α with 71%, 71%, and 83% inhibition, respectively. Compounds 1 and 8 significantly inhibited the production of IL-1β with 64% and 78% inhibition, respectively.

Conclusion:

Compounds 1 and 8 significantly inhibited the production of IL-1β with 64% and 78% inhibition, respectively. Notably compound 8 showed the most potent inhibition of these cytokines. Additionally, the effect of compounds on viability of THP-1 cells was also evaluated. Moreover, molecular docking was carried out to study the mechanism of inhibition of TNF-α production.
Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer
Authors: Elhossary Marwa , Hawash Nehah , Badawi Rehab , Yousef Mohamed , Abd-Elsalam Sherief , Elhendawy Mohammed , Wasfy Rania , Abou-Saif Sabry , ElBendary Amal , Ismail Saber
Published: June 2019

Background:

Effective screening of colorectal cancer (CRC) in early stage could reduce the advancement of CRC and therefore mortality. Effective screening is based on either stool dependent tests or colon dependent examination.

Aim:

The aim of the study was a comparative evaluation of chromocolonoscopy and Colon Cancer-Specific Antigen-2 test for early detection of colorectal cancer in Egyptian patients.

Methods:

This case control study was carried out on 55 patients classified into 3 groups: Group I consisted of twenty patients with precancerous lesions detected by colonoscopy, Group II consisted of twenty patients diagnosed with colorectal cancer and Group III consisted of fifteen individuals (who underwent colonoscopy for other indications) as a control group. All the subjects were subjected to measure occult blood in the stool, measurement of Colon Cancer-Specific Antigen-2 level in serum and tissue and chromo colonoscopy using Indigo Carmine stain.

Results:

In group II, there was a statistically significant increase in CCSA2 in serum as compared to the other 2 groups. Cutoff >11.3 CCSA2 in serum showed 65% sensitivity, 85% specificity, 81.2% PPV, 70.8% NPV and 70.3% accuracy in the differentiation of group II with cancer colon from group I with premalignant colonic lesions. A cutoff > 9.1 CCSA2 in serum showed 95% sensitivity, 46.67% specificity, 70.4% PPV, 87.5% NPV and 73.5% accuracy in differentiating group II with cancer colon from normal controls (group III).

Conclusion:

CCSA-2 level in serum was significantly higher in cancer colon. Chromoendoscopy has a role in the detection of polyps, both neoplastic and non-neoplastic.
Thyroid Peroxidase Antibody (TPO) as a Predictor of Radiation Induced Thyroid Dysfunction Among Nurses and Technicians Working in Mansoura Specialized Medical Hospital: Cross Sectional Study
Authors: Albehairy Ahmed , Fathy Sherif , Bahriz Rania
Published: June 2019

Background::

Thyroid gland is a probable goal tissue for radiation-related injury. Occupational
exposure to ionizing radiation leads to thyroid dysfunction and exposure to high dose may lead
to thyroid carcinoma.

Objective::

Evaluation of the role of Thyroid peroxidase antibody as a predictor for thyroid dysfunction
among nurses and technicians in the radiology department in Mansoura Specialized Medical hospital
(MSMH).

Subjects and Methods::

Subjects were Nurses and technicians who are working in (MSMH) with persistent
daily duty in the last 3 years and fulfilling the inclusion and exclusion criteria. All subjects included
in the study were recruited in one month and divided into two groups; Group 1: 50 subjects
who were working in radiology, coronary angiography and ERCP unit, Radiation -exposed group.
Group 2: 33 subjects who were working in In-patient departments and in out- patient clinics and not
exposed to any type of radiation. Non fasting blood sample was taken from all enrolled subjects for
measurement of TSH and Anti-TPO.

Results::

TPO was positively and significantly correlated to age, TSH, duration of radiology/ y
(r=0.388, 0.364, 0.342respectively) p value <0.05. Roc curve was done to detect the sensitivity and
specificity of TSH in relation to TPO that revealed the cutoff value of TSH > 1.69 with Sensitivity and
Specificity. PPV, NPV and accuracy at cutoff >1.69 were 70.6%, 51.5%, 42.8%, 77.3% and 58%.

Conclusion::

Working personnel with positive anti TPO and their TSH levels are more than 1.69 associated
with symptoms of hypothyroidism, a trial of treatment is mandatory to relieve symptoms.
PİEZO UYGULAMALI AKILLI TEKSTİL UYGULAMASI
Authors: GÖK Mustafa Oğuz , KARADÖL İsrafil , ŞEKKELİ Mustafa
Published: June 2019

Tekstil, ilk zamanlarda örtünme ve korunma amacı
ile ortaya çıkmış bir terimdir. Gelişen teknoloji ve değişen şartlar ile
birlikte insanların tekstil ürünlerinden beklentileri de her geçen gün
artmaktadır. Tüm bu gereksinimleri yerine getirebilmek için tekstil de kendini
geliştirerek ve farklı bilim dalları ile iş birliği içerisine girerek
fonksiyonel ve katma değeri yüksek ürünler ortaya çıkarmaktadır. Tekstilde
katma değeri yüksek ürünler deyince akla ilk gelen ürün grubu teknik
tekstillerdir. Teknik tekstiller kendi içerisinde çeşitli sınıflara
ayrılmaktadır. Bu sınıfların önemli bir tanesi de akıllı tekstillerdir. Akıllı
tekstillerin önemli bir kısmını ise elektronik tekstiller oluşturmaktadır.
Elektronik tekstiller; içerisinde elektronik devre elemanlarının bulunduğu
tekstil ürünleridir. Bu çalışmada elektronik bir malzeme olan piezoelektrik
malzemeler kullanılarak bir tasarım gerçekleştirilmiştir. Uygulanan basınç
sonucunda bir gerilim elde edilmektedir. Elde edilen bu gerilim elektrik
enerjisine dönüştürülmektedir ve tasarlanan tekstil ürününe enerji
sağlanmaktadır. Bu çalışmada üretilen elektrik enerjisi ayakkabıya
yerleştirilen ve tasarlanan sistem üzerindeki led’i yakarak estetik ve işlevsel
bir ürüne dönüşmektedir. Çalışma sonucunda hareket halindeyken enerji kaynağına
ihtiyaç duymadan mekanik enerjiyi elektrik enerjisine dönüştüren bir tasarım
oluşturulmuştur.
Understanding the globally harmonized system of classification and Labeling of Chemicals-The Purple Book
Authors: Rao Bayya Subba
Published: June 2019

Global Harmonized System (GHS), relating to hazard chemicals, is a process of making a regulation among countries uniform to the extent possible so as to benefit an industry to export its products to several countries with one communication system.  On one side, the system is helpful to develop communication as labeling and material safety data sheets, and on the other side is helpful for the personnel in the chemical and pharmaceutical industry in using chemicals carefully, especially hazardous.  Such international guidelines are believed to be the most reliable information so that the end user of hazard chemicals is confident enough in handling and using. The current article is a brief understanding of the guideline, an attempt, how the hazard chemicals are being classified, communicated as labels, symbols and material safety data sheets.
Simultaneous estimation of xanthine alkaloids (Theophylline, Theobromine and Caffeine) by High-Performance Liquid Chromatography
Authors: Mourya Shruti , Bodla Ramesh , Taurean Ravikant , Sharma Akanksha
Published: June 2019

Methylxanthines are mainly a group of phytochemicals which are derived from purine base xanthine. These xanthines are obtained from plant as a result of secondary metabolism. There are various physiological actions that have been attributed to these derivatives in neurogenerative diseases, respiratory diseases, cancer and diabetes. The aim of this study is to develop a suitable qualitative and quantitative method for these xanthine derivatives. HPLC method is suitable for simultaneous estimation of methylxanthines, based on their physicochemical properties. Theobromine, Theophylline and Caffeine that belongs to alkaloids possess their economic effects. They have various stimulant effects on cardiovascular system, gastrointestinal system, respiratory system, central nervous system etc. that results in increased motivation to work, increased energy and increased alertness. High performance liquid chromatography is used for simultaneous determination of theophylline, theobromine and caffeine from different tea leaves.
Pre-filled syringes in developed and developing region: An insight into Regulatory considerations
Authors: Kapoor Anjali , Aggarwal Geeta
Published: June 2019

A Pre-filled syringe is a disposable syringe that is supplied already loaded with the substance to be injected. It is a unit dose of parenteral medication to which a needle has been fixed by a producer. They are small which make them easy to carry and are dependable for delivering a precise dose of medication. These reasons are leading to growth of parenteral medication in pharmaceutical market. The intent of this review article is to provide information on regulatory guidelines involved in submission approach for marketing authorization of pre-filled syringe in developed region (USA, EU) and developing region (India). It also further explains about complexities associated with Pre-filled syringes in terms of regulations, submission approaches and quality development considerations in developing region. There is a need to develop an effective regulatory framework to make regulations of Pre-filled syringes more comprehensive for regulatory bodies. A harmonized forum to be made through which single application can be made and single review process can be followed to avoid deviations in regulatory pathways.
Overview of current Regulations governing Medical Devices
Authors: George Bobby
Published: June 2019

Medical Device (MD) is one of the fastest growing sector and so are the associated regulations. From lack of even policies and guidelines to stringent MD legislations in others, the requirements vary across countries. Understanding and interpreting the global MD evolving regulations and requirements is important (for not just the manufacturers, importers, wholesalers and distributors but even the clinicians) in the current global competitive market. This review is an attempt to do that by giving an overview of the prevailing MD regulations in United States (U.S), Europe and India.
Complex effect of Robinia pseudoacacia L. and Ailanthus altissima (Mill.) Swingle growing on asbestos deposits: Allelopathy and biogeochemistry
Authors: Grbovic Filip , Gajic Gordana , Brankovic Snezana , Simic Zoran , Vukovic Nenad , Pavlovic Pavle , Topuzovic Marina
Published: June 2019

Asbestos is widely mined and used around the globe posing a great risk to environment and human health. The main objective of this study was to determine allelopathic potential of Robinia pseudoacacia L. and Ailanthus altissima (Mill.) Swingle growing on the asbestos deposits at abandoned mine ?Stragari? in central Serbia. The pH, content of carbon, nitrogen, calcium carbonate, available phosphorous and potassium, content of Fe, Ni, Cu, Zn, Pb, Mn, and phenolics were analyzed in the control asbestos (zones without vegetation cover) and plant rhizospheric asbestos. Allelopathic activity of plant species was assessed by ?rhizosphere soil method?, and Trifolium pratense L. and Medicago sativa L. were used as the indicator species. A. altissima showed higher allelopathic potential compared to R. pseudoacacia for T. pratense and M. sativa due to greater content of phenolics. Alleopathic activity of phenolics in rhizospheric asbestos was highly correlated with pH, content of carbon and nitrogen, available phosphate and potassium, and content of Ni, Cu, Zn, Pb and Mn. A. altissima increased phenolics content in rhizospheric asbestos inhibiting the plant growth. This woody plant in spite of high allelopathic potential is suitable for revegetation of distrurbed ecosystems because it initiates pedogenesis and affects the asbestos chemistry.
KEMENANGAN PETAHANA DALAM KONTESTASI PILKADA SERENTAK 2018: DITINJAU DARI PERSPEKTIF POWERCUBE
Authors: Fadli Andi Muh. Dzul , Tobarasi Indrawan , Rusba Komeyni
Published: June 2019

AbstrakPemilihan Kepala Daerah (Pilkada) di Indonesia telah dilaksanakan secara serentak sebanyak 3 (tiga) kali yakni pada tahun 2015, 2017, dan 2018. Secara filosofis, pilkada serentak dilaksanakan untuk mengefisiensikan anggaran, menekan pelanggaran dan kecurangan (electoral malpractices) serta meminimalisir gejala sosial-politik dari adanya pilkada yang sebelumnya dilaksanakan secara terpisah berdasarkan periode akhir masa jabatan setiap kepala daerah. Berangkat dari fenomena persentase kemenangan para petahana di berbagai kontestasi pilkada 2018, maka menarik dikaji untuk memaknai faktor-faktor yang menyebabkan kemenangan para petahana tersebut. Dalam kajian ini digunakan pendekatan kualitatif terhadap berbagai literatur terutama yang bertalian dengan pengoperasian bentuk-bentuk kekuasaan dalam perspektif teori kubus kekuasaan (the powercubetheory).Penulis mengumpulkan danmereview literatur kontemporer yang relevan dengan fenomena yang dikaji secaradialektis dengan cara melakukan reviewdan menganalisisnya secara kritis atasberbagai sumber literatur yang terpilih. Hasil kajian menunjukkan bahwa ada 3 (tiga) bentuk kekuasaan sebagai faktor kemenangan petahana, yakni:Pertama, bentuk kekuasaan yang terlihat (visible power)ialahkesempatan untuk menarik simpati masyarakat melalui jualan program pembangunan yang telah dilaksanakan sebagai investasi politik. Kedua, bentuk kekuasaan yang tersembunyi(hidden power) ialah politisasi birokrasi melalui mobilisasi aparatur sipil negara, monopoli dukungan partai politik, dan kooptasi terhadap penyelenggara pemilu. Ketiga, bentuk kekuasaan yang tidak terlihat (invisible power), melalui peranan pemuka agama dan pemangku adat untuk menanamkan nilai-nilai dan ideologi merupakan modalitas politik petahana sebagai konsekuensi dari stratifikasi sosial-masyarakat.
Democratização ou massificação do Ensino Superior no Brasil? | Higher Education in Brazil: democratization or massification?
Authors: Barbosa Maria Ligia Oliveira
Published: June 2019

Este artigo busca compreender em que medida o Sistema de Ensino Superior brasileiro, que apresentou um notável processo de expansão em relação ao número de matrículas nas últimas décadas, tem oferecido, ou não, maior igualdade de oportunidades educacionais e sociais. Em sentido complementar, visa analisar os possíveis graus de democratização do Ensino Superior no Brasil. O texto explora a estrutura geral do Sistema de Ensino Superior no Brasil, a seletividade no acesso aos cursos de graduação e informações sobre depois do acesso a partir de informações principalmente aquelas disponibilizadas pelo Instituto Brasileiro de Geográfia e Estatistica e pelo Instituto Nacional de Educação e Pesquisa. Como resultado, sugere que apesar de alguma abertura no acesso, características como origem social, raça e sexo ainda são um fator muito relevante na definição da trajetória social. Ademais, há fortes indícios de que algumas características desse sistema poderiam ser, hipoteticamente, lidas como barreiras institucionais e fatores de aumento e não de redução das desigualdades. Estudantes menos favorecidos socialmente (pobres, negros e mulheres) são “encaminhados” para os setores e instituições menos prestigiados do sistema de ensino. As evidências nessa direção começam a ser pesquisadas no nosso país, tornando o debate sobre a democratização do Ensino Superior um ponto essencial na construção de uma sociedade melhor.
The self-similarity properties and multifractal analysis of DNA sequences
Authors: Durán-Meza G. , López-García J. , del Río-Correa J.L.
Published: June 2019

In this work is presented a pedagogical point of view of multifractal analysis deoxyribonucleic acid (DNA) sequences is presented. The DNA sequences are formed by 4 nucleotides (adenine, cytosine, guanine, and tymine). Following Jeffrey’s paper we associated a simple contractive function to each nucleotide, and constructed the Hutchinson’s operator W, which was used to build covers of different sizes of the unitary square Q, thus Wk
(Q) is a cover of Q, conformed by 4
k
squares Qk
of size 2
−k
, as each Qk
corresponds to a unique subsequence of nucleotides with length k : b
1
b
2
...bk
. Besides, it is obtained the optimal cover Ck
to the fractal F generated for each DNA sequence was obtained. We made a multifractal decomposition of Ck
in terms of the sets Jα
conformed by the Qk
’s with the same value of the Holder exponent α, and determined f (α), the Hausdorff dimension of Jα
, using the curdling theorem.