bluuebunny/crossref_metadata_2025 huggingface dataset:
Marijuana and the lung: hysteria or cause for concern?
Authors: Ribeiro Luis , Ind Philip W.
Published: September 2018

Increasing cannabis use and legalisation highlights the paucity of data we have on the safety of cannabis smoking for respiratory health. Unfortunately, concurrent use of tobacco among marijuana smokers makes it difficult to untangle individual effect of marijuana smoking. Chronic cannabis only smoking has been shown in large cohort studies to reduce forced expiratory volume in 1 s/forced vital capacityviaincreasing forced vital capacity in chronic use contrary to the picture seen in tobacco smoking. The cause of this is unclear and there are various proposed mechanisms including respiratory muscle training secondary to method of inhalation and acute anti-inflammatory effect and bronchodilation of cannabis on the airways. While cannabis smoke has been shown to increase symptoms of chronic bronchitis, it has not been definitively shown to be associated with shortness of breath or irreversible airway changes. The evidence surrounding the development of lung cancer is less clear; however, preliminary evidence does not suggest association. Bullous lung disease associated with marijuana use has long been observed in clinical practice but published evidence is limited to a total of 57 published cases and only one cross-sectional study looking at radiological changes among chronic users which did not report any increase in macroscopic emphysema. More studies are required to elucidate these missing points to further guide risk stratification, clinical diagnosis and management.

Key points

Cannabis smoking has increased and is likely to increase further with relaxation of legalisation and medicinal use of cannabinoids.

Chronic marijuana smoking often produces symptoms similar to those of chronic tobacco smoking such as cough, sputum production, shortness of breath and wheeze.

Cessation of marijuana smoking is associated with a reduction in respiratory symptoms and no increased risk of chronic bronchitis.

Spirometry changes seen in chronic marijuana smokers appear to differ from those in chronic tobacco smokers. In chronic marijuana smokers there is an increase in FVC as opposed to a definite decrease in FEV1.

Multiple case series have demonstrated peripheral bullae in marijuana smokers, but no observational studies have elucidated the risk.

There is currently no clear association between cannabis smoking and lung cancer, although the research is currently limited.

Educational aims

To update readers on legalisation of recreational and medicinal cannabis.

To summarise the evidence base surrounding the respiratory effects of inhaled marijuana use.

To provide clinicians with an understanding of the main differences between cannabis and tobacco to be able to apply this to patient education.

To highlight common respiratory problems among cannabis users and the need for recreational drug history taking.
Praktische Theologie und Kirchengeschichte
Authors: Schröder Bernd
Published: September 2018

Der Beitrag identifiziert mit den Stichworten »Historisierung«, »Pluralisierung« und »Per­spektivierung« einige grundlegende methodologische Herausforderungen historischen For­schens. Gleichzeitig weist er diese Dimension als unverzichtbaren Bestandteil praktisch-theo­logischer Urteilsbildung aus, benennt Themen historischer Arbeit in der jüngeren praktischen Theologie, potentielle Themen einer Zusammenarbeit zwischen praktischer Theologie und Kirchengeschichte und abschließend Funktionen historischer Arbeit innerhalb der Praktischen Theologie.
Kontextsensibel! Zum Gespräch zwischen Patristik und Poimenik
Authors: Heyden Katharina
Published: September 2018

Angesichts des Grabens zwischen normativen und präskriptiven Zugängen zur christlichen Seelsorge in der Antike plädiert dieser Beitrag für einen kontextsensiblen Dialog zwischen Patristik und Poimenik. Dies erfordert auf beiden Seiten eine methodisch sorgfältige Refle­xion von und einen angemessenen Umgang mit eigenem Nichtwissen und der Fremdheit des Gegenübers - und damit eine Haltung, die historische Forschung und Seelsorge miteinander verbindet. Die Autorin charakterisiert bischöfliche, monastische und freundschaftliche Seel­sorge unter Laien als drei Kontexte antiker Seelsorge und zeigt sowohl Anknüpfungspunkte als auch Stolpersteine für die heutige Theorie und Praxis von Seelsorge auf.
Geschichtswissenschaft – Kirchengeschichte – Praktische Theologie Eine Standortbestimmung
Authors: Westphal Siegrid , Leppin Volker , Weyel Birgit
Published: September 2018

Im Dialog zwischen Geschichtswissenschaft und Kirchengeschichte zeichnet sich Einigkeit über einerseits eine hochgradige interdisziplinäre Vernetzung, andererseits eine Gemeinsam­keit der Methoden ab. Letztere wird durch die Geschichtswissenschaft bestimmt, es besteht aber ebenfalls Einigkeit darüber, dass innerhalb des vorwiegend kulturwissenschaftlich ori­entierten Kanons die Kirchengeschichte eigenständig Akzente setzen kann und sollte. So spiegeln sich hier im Blick auf Interdisziplinarität und kulturwissenschaftliche Einbindung auf historischer Ebene Debatten, die der Praktischen Theologie vertraut sind, welche historische mit empirischen Perspektiven verknüpft.
The marketing strategy of firms: an inside out perspective
Authors: Durie Aschalew Degoma , Andualem Dr. Getie
Published: September 2018

The objective of the study was to examine the marketing strategies of Ethiopian medium and large textile companies. The textile sector became the focus of this study because the sector has performed far below than expected, despite the government‘s continued support to and the country‘s comparative advantage in the sector. To attain the stated objective, qualitative research approach with case study design was employed. The case companies were selected based on two criteria; production of finished textile products and operation in both local and global markets. Accordingly, nine companies qualified these criteria and all of them were used as cases. The RBT was the theory employed to explain the differences in performances among firms’ in similar environment. Furthermore, within and cross case analyses were employed to get in-depth understanding about the marketing strategies of the case companies.
The contribution of green logistics and sustainable purchasing for green supply chain management
Authors: Teixeira Cassia Regina Bianchini , Assumpção Andre Luis , Correa Andre Luiz , Savi Antonio Francisco , Prates Glaucia Aparecida
Published: September 2018

The search for new technologies that can mitigate the negative impacts caused by the processes of production and the excessive consumption of raw material, has gained more and more relevance in the business world. In this scenario, the present research aims to identify the contributions that green logistics and green procurement bring to the management of the green supply chain. The present research is justified by the increase in the adoption of ecological practices by the companies, which implies in the continuous search for improvement of the techniques that involve all the practices within the Chain of Green Supply, aiming at greater efficiency of the whole chain. ISO 20400 was implemented, which came into force in 2017, which aims to increase the efficiency of green purchasing practices. The method used was the qualitative exploratory bibliographic research carried out in the secondary databases ACM, EBSCO, Emerald, Academic OneFile (GALE), Scielo, Sciense Direct, Springer, Web of Science and Wiley. A bibliometric analysis of the information obtained was performed. The research concluded that Green Supply Chain Management aims to reduce waste, negative impacts on the environment and maximize profitability. It increases competitiveness through innovative strategies aligned with the organization's strategic objectives, green logistics and green procurement in particular. contribute to reducing carbon dioxide emissions by replacing fossil fuels with alternative fuels, reducing operating costs, adapting transport modes, improving internal communication technologies, investing in personnel training to achieve sustainability.
Influence of pegylated interferon and ribavirin on insulin resistance and metabolic factors in chronic hepatitis C
Authors: Altın Zeynep , Diniz Gülden , Çolak Ayfer , Koyuncu Betül , Özer Serhat , Aslan Fatih , Ünsal Belkıs
Published: September 2018

Background

In this study it was aimed to evaluate the effect of pegylated interferon alfa-2a/2b and ribavirin, which are used for treatment of chronic hepatitis C (CHC), on insulin resistance and metabolic factors.

Materials and methods

A total of 104 CHC patients aged 20–75 years with available serum insulin data at 0 and 48 weeks, and hepatitis C virus (HCV)-RNA data at 0, 12, 24, 48 and 72 weeks were included in the study. All clinical para-meters were assessed according to the therapy response.

Results

Among 104 patients, sustained virologic response (SVR) was achieved in 55 cases. A statistically significant difference was noted between SVR and non-SVR groups regarding γ-glutamyltranspeptidase (GGT), insulin level plus homeostasis model assessment (HOMA) score and insulin resistance at week 48, log HCV-RNA and stage of fibrosis.

Conclusion

Insulin resistance is accepted to have a negative effect on SVR. Insulin resistance may improve once SVR is achieved. Presence of IR at week 48 has been found associated with SVR. In this context, it can be advocated that insulin resistance at week 48 may be a predictive factor for prediction of SVR at week 72.
Determinación de los valores de referencia en el hemograma de caballos nacidos o criados entre 0 y 500 m.s.n.m. en la región litoral del Ecuador
Authors: Luna Narváez Diego Fernando , Hernández Toro Karen Elizabeth , Rolando Chacha Vega Sergio , Cedeño Prócel Yolanda Mercedes
Published: September 2018

El presente trabajo se realizó en la región litoral del Ecuador, en donde se analizaron los hemogramas de 100 caballos criollos clínicamente sanos, mayores a dos años de edad y criados entre los 0 y 500 metros sobre el nivel del mar, para cumplir con los objetivos de determinar los valores hematológicos de referencia y comparar los resultados obtenidos con los valores de referencia de un estudio previo, realizado a más de 3000 m.s.n.m en la sierra centro norte ecuatoriana. Se obtuvieron las muestras sanguíneas de animales en reposo, se realizaron los análisis de laboratorio con el equipo de auto-hematología Mindray RBC2800Vet y posteriormente se hizo un análisis estadístico utilizando el complemento de Microsoft Excel R“Reference Value Advisor” para determinar los valores de referencia y eliminar los valores anómalos. Se prefirió tomar la muestra de caballos criollos ecuatorianos para tener una muestra con parámetros sanguíneos homogéneos y una referencia de esta variedad antes solamente estudiada sobre los 3000 m.s.n.m. Se encontraron los siguientes valores; eritrocitos: 4,90-9,38x106/mL, hematocrito: 24,83-45,10%, hemoglobina: 8,59-14,87g/L, VCM: 42,35-55,19fL, HCM: 14,25-18,20pg, CHCM: 32,10-36,70g/L, glóbulos blancos: 5,64-12,81x103/mL, linfocitos: 1,04-5,85x103/mL, monocitos: 0,20-0,90x103/mL, granulocitos: 2,90-8,26x103/mL y plaquetas: 78,10-314,90x103/mL. En la comparación con los resultados obtenidos se encontraron diferencias significativas (P<0,05) en el contaje de eritrocitos, concentración de hemoglobina, hematocrito y contaje de plaquetas debido a la influencia de la altura; también se encontraron diferencias significativas (P<0,05) en la serie blanca (leucocitos, linfocitos, monocitos y granulocitos) pero esto debido a influencias fisiológicas o patológicas, mas no al efecto altitudinal.
Efecto de la inclusión alimenticia de betaína en cerdos en fase de finalización
Authors: Paéz Bustillos Romel Joaquín , Grijalva Olmedo Jorge Eduardo , Quisirumbay-Gaibor Jimmy
Published: September 2018

El consumidor de carne porcina demanda de un producto de calidad y con menor contenido de grasa, exigiendo que el nutricionista busque nuevas alternativas en la alimentación del cerdo. El objetivo de este estudio fue evaluar el efecto de la inclusión dietaria de betaína. Los parámetros productivos y rendimiento a la canal fueron evaluados, un total de 30 de cerdos machos castrados en fase de finalización (Landrace _ Yorkshire) fueron alimentadas con una dieta control o con la dieta experimental adicionada con 0.1% de betaína durante 29 días. El consumo diario promedio de alimento (CDPA) fue similar en ambos grupos (P>0.05). La ganancia diaria promedio de peso (GDP), conversión alimenticia (CA) y rendimiento a la canal (RC) para los cerdos alimentados con la dieta de betaína fue significativamente mayor (p<0.05) en comparación con la dieta no suplementada. El espesor de grasa dorsal (EGD)fue menor en el grupo experimental (p<0.05). La inclusión alimenticia de betaína al 0.1%en fase de finalización mejora la ganancia diaria de peso, conversión alimenticia y disminuye el contenido de grasa de la canal
Overview on Antibody-drug Conjugates Development v1
Authors: Smith Bella
Published: September 2018

Since the 20th century, medical scientists represented by Paul Ehrlich, the father of chemotherapy, have been searching for such a "magic bullet" that distinguishes between pathogens and normal cells. Since the beginning of the new century, more and more people believe that antibody-drug conjugate (ADC) is the answer that has long been sought.
POTENSI KOLAGEN TERIPANG EMAS SEBAGAI INHIBITOR TIROSINASE
Authors: Safithri Mega , Setyaningsih Iriani , Tarman Kustiariyah , Yuhendri Vitriyanna Mutiara , Meydia Meydia
Published: September 2018

Kolagen memiliki aktivitas antioksidan dan mampu menghambat aktivitas tirosinase pada proses
melanogenesis, salah satu biota laut yang dapat dijadikan sumber kolagen alternatif adalah teripang.
Penelitian ini bertujuan menentukan karakteristik kolagen dan aktivitas penghambatan enzim tirosinase
oleh kolagen teripang emas (Stichopus hermanii). Penghilangan protein non kolagen dilakukan dengan
cara perendaman daging teripang menggunakan NaOH 0,1 M selama 48 jam. Isolasi kolagen dilakukan
menggunakan asam asetat 0.5 M selama 48 jam. Analisis gugus fungsi kolagen dilakukan menggunakan
FTIR dan analisis aktivitas tirosinase dilakukan menggunakan spektrofotometer. Kadar protein non
kolagen yang diperoleh yaitu 0,090 mg/mL dan kolagen teripang emas memiliki rendemen 0,66%. Kolagen
teripang memiliki nilai pH 6,91, gugus fungsi khas amida A (3379,29 cm-1), amida B (2924,09 cm-1), amida
I (1681,93 cm-1), amida II (1568,13 cm-1), dan amida III (1269,16 cm-1). Aktivitas penghambatan tirosinase
menunjukkan bahwa kolagen teripang emas memiliki nilai IC50 5610 ppm. Kolagen teripang emas belum
mampu menghambat aktivitas tirosinase.
Barriers and enablers for cervical cancer screening in the Pacific: A systematic review of the literature.
Authors: Elia Clerah R , Devine Sue
Published: September 2018

Background: Globally cervical cancer is the fourth most common type of cancer in women and in some low-income countries is the most common cancer in women. Papua New Guinea has a particularly concerning incidence of cervical cancer where it ranks first as the leading cause of cancer in females. Screening is a reliable strategy to detect cervical cancer but implementation of screening in Papua New Guinea is poor. The aim of this review is to identify the enablers and barriers for cervical cancer screening in Papua New Guinea.

Methods: A systematic search of peer-reviewed literature was conducted using electronic databases; PubMed, Medline, Scopus, CINAHL and Google Scholar. Articles published between 2007 and 2017 that focused on the enablers and barriers to cervical cancer screening were included. Only one study from Papua New Guinea was identified so the search was extended to include other Pacific Island Countries and Low-Income Countries more broadly.

Findings: Twenty articles met the inclusion criteria. The main barriers for cervical cancer screening included a lack of women’s knowledge about cervical cancer and screening, a lack of health facilities for screening, diagnosis and treatment, lack of health care worker knowledge and training, cultural beliefs and financial burdens. The main enablers included women having access to education programs, availability of cervical cancer screening services, female friendly environments and health care workers being trained to undertake screening.

Conclusions: While the literature highlighted the importance of cervical cancer screening, a range of barriers limits the delivery of this service in low-income country settings.  In particular, there is a gap in the knowledge of barriers and enablers within Papua New Guinea and further research in this country is required. Applying the knowledge learned from other low-income countries and gaining a clearer understanding of both the barriers and enablers for cervical cancer screening in the Papua New Guinea context may lead to clear recommendations to improve implementation and uptake of cervical cancer screening.
Um ensaio teórico sobre marca-país e sua gestão
Authors: Montanari Maria Gabriela , Giraldi Janaina de Moura Engracia
Published: September 2018

Este artigo apresenta um ensaio teórico visando esclarecer o conceito de marca-país, diferenciando-o de imagem de país e efeito país de origem, e também detalhar sua gestão, explorando sua complexidade e suas diferenças em relação à gestão de marcas de produtos e serviços. Fundamentado na literatura, verificou-se que a marca-país deriva de um processo gerencial, o country branding (gestão de marca-país), que objetiva diferenciar a nação e suas ofertas no mercado internacional com base em sua cultura.  Esse processo engloba desde a criação da marca-país até sua comunicação para os diversos públicos alvo, é mais complexo do que para produtos e serviços, e deve considerar os elementos de identidade, posicionamento e imagem de país. A imagem de país muitas vezes é o foco das ações de branding, pois consiste nas associações sobre o país que os consumidores internacionais sustentam em sua memória e é avaliada como uma ferramenta fundamental que pode aumentar o poder da marca-país. Assim, foi possível contribuir tanto para a teoria de marca-país e sua gestão, quanto para os governos, fornecendo informações relevantes que auxiliam na delimitação de ações estratégicas em relação à marca-país e a sua imagem.
Challenges and opportunities for assessing transport properties of high-performance concrete
Authors: Yang Kai , Nanukuttan Sreejith , McCarter W. John , Long Adrian , Basheer Muhammed
Published: September 2018

In this paper, a review of techniques is given so that both, the challenges and opportunities for assessing transport properties of high-performance concrete, are highlighted. A knowledge of performance of structural concrete is required for design and compliance purposes. One driving force for the use of high performance concretes (HPC) is enhanced durability yet it would be wrong to assume that all HPCs can deliver the desired performance level. In situ characterisation of the permeation properties of concrete is the most viable means for assessing durability and has become increasingly important over the past 20 years. A variety of methods exist that provide a range of parameters, e.g. air permeability, water absorption rate, sorptivity and chloride migration coefficient.
Service life design and modelling of concrete structures – background, developments, and implementation
Authors: Alexander Mark Gavin
Published: September 2018

The paper presents an overview of current knowledge and progress in service life design and modelling of concrete structures, taking an international view but also giving local examples from South Africa. It raises the question of why service life modelling is needed, and indicates that modern demands for longevity, durability, and sustainability of concrete structures cannot be fulfilled without service life modelling. It addresses the current approaches to durability design and specification and concludes that a move to performance-based approaches is imperative if progress is to be made. Examples from international experience are cited to illustrate progress that has been made. Lastly, the paper discusses ways of moving forward, recognizing that the philosophical bases are already firmly in place in the form of general code formulations, but these need to be converted into useful approaches.
Coeficiente de difusão aparente de oxigênio e o controle da corrosão de armaduras revestidas com primers
Authors: Pazini Enio , Andrade Carmen
Published: September 2018

O presente trabalho avalia a influência de diferentes revestimentos aplicados nas armaduras sobre o coeficiente de difusão aparente de oxigênio (Dap(O2)) e sobre a intensidade de corrosão (Icorr), comparando os resultados com um revestimento de referência (argamassa cimentícia). O fluxo de oxigênio (J(O2)) até a armadura foi medido pelo método potenciostático no estado estacionário. A Icorr foi monitorada pela técnica de Resistência de Polarização. Avaliações referentes a porosidade dos revestimentos foram feitas por meio de lupas, microscopia ótica e SEM. Os revestimentos que representam sistemas de proteção por barreira mostraram-se menos permeáveis ao oxigênio. Os valores Dap(O2) variaram de 2,1 x 10-6 cm2/s até 4 x 10-9 cm2/s, ocasionando variações na Icorr, devido ao controle catódico do processo de corrosão.
Use of Smartphone-Based Head-Mounted Display Devices to View a Three-Dimensional Dissection Model in a Virtual Reality Environment: Pilot Questionnaire Study (Preprint)
Authors: Masuoka Yoshihito , Morikawa Hiroyuki , Kawai Takashi , Nakagohri Toshio
Published: September 2018

BACKGROUND

Virtual reality (VR) technology has started to gain attention as a form of surgical support in medical settings. Likewise, the widespread use of smartphones has resulted in the development of various medical applications; for example, Google Cardboard, which can be used to build simple head-mounted displays (HMDs). However, because of the absence of observed and reported outcomes of the use of three-dimensional (3D) organ models in relevant environments, we have yet to determine the effects of or issues with the use of such VR technology.

OBJECTIVE

The aim of this paper was to study the issues that arise while observing a 3D model of an organ that is created based on an actual surgical case through the use of a smartphone-based simple HMD. Upon completion, we evaluated and gathered feedback on the performance and usability of the simple observation environment we had created.

METHODS

We downloaded our data to a smartphone (Galaxy S6; Samsung, Seoul, Korea) and created a simple HMD system using Google Cardboard (Google). A total of 17 medical students performed 2 experiments: an observation conducted by a single observer and another one carried out by multiple observers using a simple HMD. Afterward, they assessed the results by responding to a questionnaire survey.

RESULTS

We received a largely favorable response in the evaluation of the dissection model, but also a low score because of visually induced motion sickness and eye fatigue. In an introspective report on simultaneous observations made by multiple observers, positive opinions indicated clear image quality and shared understanding, but displeasure caused by visually induced motion sickness, eye fatigue, and hardware problems was also expressed.

CONCLUSIONS

We established a simple system that enables multiple persons to observe a 3D model. Although the observation conducted by multiple observers was successful, problems likely arose because of poor smartphone performance. Therefore, smartphone performance improvement may be a key factor in establishing a low-cost and user-friendly 3D observation environment.
Effects of Nanomaterials on Oxidative Stress and Protein Oxidation in Biological System: Biochemical and Biological Aspects
Authors:   Medwin, YK Lahir
Published: September 2018

Oxidation and reduction is a ubiquitous phenomenon reflecting the structural, functional aspects of cell, tissue, organ and organism. Primarily oxidative process in a biological system is the imprint of structural and functional integrity because of its role to maintain a state of healthy equilibrium. This homeostatic state is the result of combined and coordinated interactions between pro oxidants, antioxidants, inactivated free radicals and oxidants present in the cell. Proteins alone and in conjugated from are amongst those biomolecules which are basically devoted to cellular structural, functional, inter and intracellular communication. Electrochemical aspects of oxidation reduction are applicable to the oxidation of proteins. High energy radiations are capable to form free radicals of oxygen, when proteins are exposed to such free radicals gross modifications in amino acids and/or fragmentation of proteins occurs. Redox metabolism reflects on the functional aspects of proteome; there is every probability that any temporal and spatial fluctuations can direct the functional aspect of cell. Conditions like resistance to insulin, dysfunction of immune system and inflammatory responses are concerned with oxidative stress. Diseased conditions and senescence are parameters directly related to the declined efficiency of antioxidant system indicating oxidative stress. This in turn is capable to causes modifications in DNA, carbohydrates, proteins and lipids. In the recent past nanotechnology has attained significant importance due to its multidimensional potentials in almost all fields of life. The nanomaterials, natural as well as engineered, are sought after to solve most of the problems related to man-kind and industries. The physicochemical properties of nanomaterials are the basis of their applications in all spheres of life. In this presentation an effort is made to over view the developments in the field of nanomaterials that have taken place in the recent past and more over their impact on redox process and protein oxidation encompassing biological, biochemical, physiological, and pathological aspects in a biological system.
PEMEROLEHAN BAHASA ANAK USIA 4 TAHUN KAJIAN SEMANTIK PENYIMPANGAN TUTURAN ANAK
Authors: Nugraha Oktavian Aditya
Published: September 2018

Penyimpangan  tuturan  yang  terjadi  pada  anak  yang  berusia  4  tahun  terjadi karena  pada  usia  tersebut,  anak  dalam  proses  penguasaan  bahasa  sesudah bahasa pertama dan setidaknya dipengaruhi oleh dua hal, yaitu faktor fisiologis dan psikologis. Faktor fisiologis meliputi organ-organ penghasil tuturan seperti mulut dan fungsi otak. Sementara itu, faktor psikologis meliputi perkembangan kognitif  seorang  anak  dalam  proses  penguasaan  bahasa  pertamanya.  Tujuan penelitian ini adalah mendeskripsikan penyimpangan tuturan bahasa anak usia 4 tahun dengan kajian semantik yang didapatkan dari pemerolehan bahasanya. Metode pengumpulan data yang digunakan adalah menggunakan metode simak dengan teknik sadap. Teknik lanjutan yang digunakan adalah berupa simak libat cakap,  rekam,  dan  catat.  Metode  analisis  yang  digunakan  mencakup  metode padan  ekstralingual  yang  digunakan  untuk  menganalisis  unsur  yang  bersifat ekstralingual, seperti menghubungkan masalah bahasa dengan hal yang berada di luar bahasa. Hasil yang diperoleh menunjukkan bahwa penguasaan bahasa anak  usia  4  tahun  bisa  dikatakan  dalam  taraf  atau  proses  perkembangan bahasa yang nantinya bisa sempurna saat usia bertambah. Penyimpangan yang ditemukan  meliputi  12  penyimpangan  kata  yang  sering  kali  diucapkan  oleh anak. Hubungan dengan semantik pemerolehan bahasa anak usia 4 tahun dinilai masih dalam tahap perkembangan sesuai dengan usia mereka. Penyimpangan tuturan  yang  ditemukan  meliputi  penyimpangan  tuturan  di  bidang  semantik yaitu ketidaksesuaian antara satu kata yang diucapkan dengan acuannya.  Kata Kunci: Pemerolehan Bahasa, Semantik, Penyimpangan Tuturan.
Zastosowanie infuzyjnego schematu chemioterapii DA-EPOCH w leczeniu chłoniaków agresywnych
Authors: Taszner Michał , Szymańska Agata , Bieniaszewska Maria
Published: September 2018

Streszczenie

Wstęp

Standardowe leczenie chłoniaków nie-Hodgkinowskich (non-Hodgkin lymphoma, NHL) oparte jest na stosowanym od ponad 30 lat schemacie CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone). W przypadku niektórych podtypów NHL, wyniki leczenia schematami CHOP-podobnymi są niewystarczające lub wymagają zastosowania uzupełniającej radioterapii. W latach 90-tych XX wieku wprowadzono do praktyki schematy leczenia polegające na podawaniu cytostatyków w długotrwałych wlewach i dawkach dostosowanych do parametrów farmakodynamicznych.

Celem pracy było przedstawienie doświadczenia jednego ośrodka w stosowaniu schematu DA-EPOCH (dose adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin) w leczeniu NHL.

Materiały i metody

Poddano obserwacji 13 chorych leczonych z powodu trzech różnych podtypów NHL: pierwotnego chłoniaka śródpiersia, chloniaka „szarej strefy“ oraz anaplastycznego chłoniaka z dużych limfocytów T. Chory z NHL z komórek T otrzymał schemat DA-EPOCH, chorzy z NHL B-komórkowymi DA-EPOCH z dodatkiem rituximabu. Ocenę odpowiedzi przeprowadzono metodą pozytonowej tomografii emisyjnej.

Wyniki

W okresie 22 miesięcy podano łącznie 94 cykle DA-EPOCH (+/-R). U wszystkich pacjentów w czasie leczenia zaobserwowano neutropenię poniżej 0,5 G/l. Spośród 13 pacjentów, u 12 oceniono odpowiedź po zakończeniu leczenia. Całkowitą odpowiedź metaboliczną uzyskano u 9 chorych, a u 2 odpowiedź częściową. Całkowity odsetek odpowiedzi wyniósł 91%. U 1 pacjentki zaobserwowano progresję NHL. Obserwowano nieznaczną toksyczność leczenia, głównie hematologiczną. Nie zaobserwowano zgonów związanych z chemioterapią.

Wnioski

Zebrane doświadczenia pozwalają uznać schemat DA-EPOCH za bezpieczny, skuteczny i łatwy do stosowania w warunkach oddziału szpitalnego.
Penggunaan Media Komunikasi Bagi Remaja Perempuan Dalam Pencarian Informasi Kesehatan
Authors: Prasanti Ditha
Published: September 2018

Health information becomes important, not only for the sick, the elderly, or the children, but also for young women. Especially considering the new media era that developed more sophisticated along with the development of technology in his day. Likewise, it happens with the writer's research informant who has a new method in the search for health information.The research review that has been done in this article is the use of female teen communication media in the search for health information. The purpose of this research is to know the communication media used by female teenager in searching health information.Â Â The results of the research have shown that the female teenagers who become informants of this research writer use various communication media. Among young women who are studying in health majors choose to use online journal literature only.
Pengaruh Celebrity Endorser Hamidah Rachmayanti Terhadap Keputusan Pembelian Produk Online Shop MAYOUTFIT Di Kota Bandung
Authors: Zahra Ratika , Rina Nofha
Published: September 2018

Utilization of internet among modern society today is the use of social media. Of the many social media that are present to be consumed by modern society and one of them is Instagram useful benefits for the delivery of new information including one that is also used dalah things do business. The emergence of the phenomenon of online shopping in social media Instagram for the vigorous business conduct marketing using supporting figures or celebrities endorser as a supporter to market their products. Seeing this phenomenon, it is necessary to do a research that.Â Hamidah Rachmayanti is a celebrity endorser used by Online Shop Mayoutfit has several purposes in this research is to determine the effect of Visibility, Credibility, Attractiveness and Celebrity Endorser Effectiveness to the Decision Purchase Online Shop Mayoutfit products. This research uses quantitative method with questionnaire distribution and using multiple linear regression.Â This study concludes that the influence of Celebrity Endorser on @hamidahrachmayanti account of 52.1% can be explained by variables consisting of Visibility, Credibility, Attractiveness, and Power.Â
ANÁLISE DA LITERATURA DA BASE DE PERIÓDICOS SPELL SOBRE A TEMÁTICA GESTÃO DA DIVERSIDADE
Authors: Queiroz Carlos Sérgio Rodrigues , Santos Geice Souza dos , Soares Luciene de Jesus E Silva , Ossuna Vanessa Da Silva , Pereira Marciane Silva
Published: September 2018

O uso do termo diversidade tem sido constante nos estudos organizacionais, isso porque a administração está intimamente relacionada à gestão da diversidade. Assim, a proposta deste artigo tem como objetivo analisar as publicações disponíveis na base da plataforma Spell no período entre 1991 a 2017 sobre o tema Gestão da Diversidade, verificar os períodos, relatando os autores que mais publicaram, as instituições de ensino superior associadas a esses autores e as principais revistas. Para tanto essa é uma pesquisa bibliométrica, com abordagem predominantemente quantitativa e breve aspecto qualitativo. Após os devidos filtros sobre o tema “Gestão da Diversidade” foram selecionados 128 artigos que foram organizados em categorias (revista, autores, IES, tema, abordagem de pesquisa). Os resultados engendrados de fato indicam a importância competitiva e estratégica para as organizações ao estudarem sobre a aprendizagem organizacional. Espera-se com esse levantamento possa contribuir para demonstrar o cenário de produção científica sobre a Gestão da diversidade e proporcionar a reflexão sobre os possíveis cursos e limitações no contexto organizacional. Como limitação destaca-se a análise em apenas uma base de dados.
MODELING THE MYSTERIOUS TSUNAMI SWIRLS IN THE NORTHEAST COAST OF JAPAN DURING THE MARCH 2011 TOHOKU EARTHQUAKE
Authors: Rivera Paul C.
Published: September 2018

The formation of tsunami swirls near the coast is an obvious oceanographic phenomenon during the occurrence of giant submarine earthquakes and mega-tsunamis. Several tsunami vortices were generated during the Asian tsunami of 2004 and the great Japan tsunami of March 2011 which lasted for several hours.New models of tsunami generation and propagation are hereby proposed and were used to investigate the tsunami inception, propagation and associated formation of swirls in the eastern coast of Japan. The proposed generation model assumes that the tsunami was driven by current oscillations at the seabed induced by the submarine earthquake. The major aim of this study is to develop a tsunami model to simulate the occurrence of tsunami swirls. Specifically, this study attempts to simulate and understand the formation of the mysterious tsunami swirls in the northeast coast of Japan. In addition, this study determines the vulnerability of the Philippines to destructive tsunami waves that originate near Japan. A coarse-resolution model was therefore developed in a relatively large area encompassing Japan Sea and the eastern Philippine Sea. On the other hand, a fine-resolution model was implemented in a small area off Sendai coast near the epicenter. The model result was compared with the tsunami record obtained from the National Data Buoy Center with relatively good agreement as far as the height and period of the tsunami are concerned. Furthermore, the fine-resolution model was able to simulate the occurrence of tsunami vortices off Sendai coast with various sizes that lasted for several hours.
Cultural psychology and phenomenological method - Book of Abstracts
Authors: Raco Jozef
Published: September 2018

Cultural psychology offers excellent ways to understand the relationshipbetween cultures and mind. It was commonly aware that individual mental lifewas constituted by culture and vice versa. Culture and mind are inseparable.To understand people way of thinking, behaviors and actions, one shouldunderstand their cultures. Culture and mind mutually relate. This is thecentral issue of the cultural psychology. Understanding people and theirculture means looking them from their context. Culture is not out there, butinside the heart of the individual. It lives in the mind and being expressedthrough people behavior and actions. Culture will determine peopleâ€™sbeliefs and ideas. Neglecting culture to understand people is totally wrong,meaningless and illogical. Research on this issue aims to get the meaning andunderstanding about those relationships. Data of this research very muchdepends on the information given and shared by participants. The rightmethod to understand the cultural psychology is phenomenological method.Phenomenological method very much emphasizes on Verstehen or meaningand understanding. It places experience as the central of its analysis. Theparticipants should have lived experience of the phenomena being searched.Understanding people behavior is only possible if we put them into theircontext. This paper will present the importance of phenomenology as amethod appropriate for cultural psychology study. It looks at the human livedexperiences and examine, comprehend, explain the meanings and set aside any pre-judgments regarding the phenomena to avoid preconceptions. Thepresenter will discuss the phenomenological method works. This method willprovide an intimate and in-depth meaning based on individual experience.This method will produce insights and findings, which is not available inother methods, and will be helpful to understand the relationship betweenthe mind and culture and vice versa.
Measurement Accuracy of Paimin Formula to Landslide Prediction in Ponorogo East Java
Authors: Phuspa Sisca Mayang , Muriyatmoko Dihin
Published: September 2018

Since 2012 to 2017, in Ponorogo East Java, Indonesia, suffered 53 timesthe occurrence of landslides and caused 7 people died, 23 missing, 1 injuredand 996 people evacuated. There are several methods to know the parameters oflandslides vulnerability areas, one of them is the Paimin formula. The purposeof this research is applied Paimin formula to predict landslides was occurredin Ponorogo from 2012 to 2017 and measuring the accuracy of Paimin formulausing Linear Regression. The prediction result of Paimin formula proves thatPonorogo has an average of landslides vulnerability area with five categories:very low 0.5912%, low 52.4465%, medium 46.0119%, high 0.9503%, andvery high 0.0002%, while the average occurrence of landslides per year is8.83 times with the percentage of landslides vulnerability areas of 16.4881 %.The accuracy of Paimin formula using linear regression resulted in value ofMultiple R = 70.70%, it is including a high correlation and value of R Square= 0.4999, indicates that the parameter and or percentage was used by Paiminformula has accuracy 49.99%, while 50.01% is influenced by other percentageand or parameters. The Paimin formula is ably applied to predict for possiblelandslides occurrence elsewhere and the prediction of landslide not only usedlinear regression but also for others algorithms.
Common Concerns with MTurk as a Participant Pool: Evidence and Solutions
Authors: Hauser David , Paolacci Gabriele , Chandler Jesse J.
Published: September 2018

In this chapter, we outline the common concerns with MTurk as a participant pool, review the evidence for those concerns, and discuss solutions. We close with a Table of considerations that researchers should make when fielding a study on MTurk
Pengurangan Resiko Kebakaran Hutan dan Lahan Melalui Pemetaan HGU dan Pengendalian Pertanahan (Studi Kasus Provinsi Riau)
Authors: Utami Westi , Ndaru Arga Yugan , Widyastuti Anggi , Swardiana I Made Alit
Published: September 2018

Abstract:  Oil palm plantation expansion through inappropriate land clearing usually trigger forest fire and peat land fire in Riau Province. The purpose of this paper is to find the method to reduce disaster risk through preventive activities, conducted by mapping the distribution of Cultivation Right, and was overlaid with the map of disaster risk and agrarian control through location permit and control of spatial planning. The method used to produce disaster-prone area map was quantitative scoring and weighting, using Composite Mapping Analysis (CMA) method based on the relationship between factors with the percentage of fire spot (hotspot). The results show that from the distribution of cultivation right based on the level of vulnerability in Riau Province, there are 45 location of cultivation right lies along very high-risk area of forest fire with the total area of 95.260,7 hectares (10,4%); most of the area, counted for 70,4% with the area of 647.140,3 hectares covering 143 Cultivation Right location, located on the vulnerable area of forest fire; while 19,2% of the total cultivation right area are in less vulnerable area, spreading over 25 Cultivation Right location. Intisari: Ekspansi perkebunan sawit melalui land clearing yang tidak tepat seringkali memicu terjadinya kebakaran hutan dan lahan gambut di Provinsi Riau.  Pengurangan resiko bencana melalui kegiatan preventif yaitu penyusunan peta sebaran HGU dioverlaykan dengan peta tingkat kerawanan bencana serta pengendalian pertanahan melalui ijin lokasi dan pengendalian melalui RTRW merupakan tujuan dari tulisan ini. Metode yang digunakan untuk menyusun peta kerawanan bencana adalah scoring dan pembobotan dilakukan secara kuantitatif menggunakan metode Composite Mapping Analysis (CMA) berdasarkan hubungan setiap faktor terhadap persentase titik api (hotspot). Hasil analisis menunjukkan bahwa dari sebaran HGU berdasarkan tingkat kerawanan di Provinsi Riau sebanyak 45 lokasi HGU berada pada daerah sangat rawan bencana kebakaran dengan total luasan 95.260,7 ha (10,4%);  sebagian besar yaitu 70,4%  dengan luasan 647.160,3 ha dengan sebaran sebanyak 143 HGU berada pada kawasan ancaman rawan terhadap bencana kebakaran hutan dan lahan; sementara 19,2% dari total luasan HGU berada pada kategori kurang rawan yang tersebar pada 25 HGU.
In-situ monitoring by thermal lens microscopy of a photocatalytic reduction process of hexavalent chromium
Authors: Cedeño E , Plazas-Saldaña J. , Gordillo-Delgado F. , Bedoya A. , Marin Ernesto
Published: September 2018

In this work, we describe the application of a micro-spatial thermal lens spectroscopy setup (thermal lens microscope, TLM) with coaxial counter-propagating pump and probe laser beams and an integrated passive optical Fabry-Perot to quantify the Cr-VI concentration in water during a photocatalytic reaction in-situ. A series of test samples was analyzed using the 1,5 diphenil carbazide colorimetric method. A calibration curve was obtained by plotting of the TLM signal as a function of the concentration of Cr(VI) in a range between 0 and 10 μg/L (1 μg/L = 1 ppb, part per billion), with a detection limit of 53 ng/L (1 ng/L = 1 ppt, part per trillion). A solution of 10 μg/L Cr(VI) in distillated water was placed into a cell in contact with an iron-incorporated titanium dioxide film, which was previously grown onto a 1 mm thick glass microscope slide by the sol-gel dip-coating technique. The TLM signal was registered as a function of the photocatalysis time measured from the beginning of the process, radiating the film with UV-violet light. The Cr(VI) concentration was determined with the calibration curve and after the first 50 minutes a reduction of 95 % of Cr(VI) was observed, being the chemical reaction kinetic described by a potential time decreasing function.
Türkçenin Sözdizimi
Authors: Oturakçı Orbay Nigâr
Published: September 2018

Türkiye Türkçesinin sözdizimi üzerine bugüne kadar pek çok bilimsel çalışma yapılmış ve yapılmaya devam etmektedir. Bildiri, makale, kitap bölümü ya da kitap olarak hazırlanan bu çalışmalarda, sözdiziminde sorun olarak görülen, çözüme ulaşılamamış, uzlaşıya varılamamış konular ele alınarak alanın gelişimine katkıda bulunma amacı güdülmüştür. Bu niyetle yola çıkan akademik çalışmalardan biri de Prof. Dr. Mehmet Özmen’in Türkçenin Sözdizimi adlı kitabıdır.
Statistical Experimental Design for the Extraction of Ti(IV) in the Ti(IV)-SO42- (H+, Na+) – Cyanex 301 – Kerosene – 5% (v/v) Heptane-1-ol System
Authors: Biswas R. K. , Karmakar A. K.
Published: September 2018

The titled system has been investigated from the modelling point of view. The equilibration time for the system is 45 min, and 5% (v/v) heptane-1-ol in the organic phase is used as a  de-emulsifier. The factors affecting the extent of extractions are [Ti(IV)], pH(eq), [Cyanex 301], [SO42-] and temperature (T). The selected levels are high (+) and low (-) for these factors in the present investigation. Model equation for the extraction of Ti(IV) by Cyanex 301 is determined from 25 full factorial design. However, the success of the factorial design depends on the linear relationship between yield and factor. Plots of log CD vs log [Ti(IV)], pH(eq), log [Cyanex 301] and log [SO42-] are curves. Logistic functions involving these factors are considered in designing. While [Ti(IV)] < 1.00 g/L and [HA](o) > 0.10 mol/L, considered logistic functions viz. -log(1+316.2 ([Ti(IV)], mol/L)), -log (10-pH + 229 ´10-2pH), log ([HA](o), mol/L), -log (1+0.79 ([SO42-], mol/L)) and absolute temperature are abbreviated as M, P, E, S and T, respectively. Model is log CD = 5.847 + 0.964 M + 0.909 P + 2 E + 0.995 S – (1437.5/T). The experimental model illustrates that there is no interaction effect between the factors under investigation.
Nonclassical transport in highly heterogeneous and sharply contrasting media
Authors: Bolshov L A , Kondratenko P S , Matveev L V
Published: September 2018

We review the physical models of nonclassical transport processes in highly heterogeneous media with different types of the spatial distribution of characteristics. We discuss transport in regularly heterogeneous, fractal, and statistically homogeneous sharply contrasting media, as well as in liquid media under the condition of Rayleigh – Benard convection. The behavior of the impurity concentration in the main localization region and at asymptotically large distances from the source is analyzed. The effect on the transport regimes arising due to the presence of colloids, as well as barriers surrounding the impurity source, is investigated. An asymptotic approach to the calculation of the concentration in a medium with large-scale heterogeneities in the distribution of transport characteristics is presented.
High Burden of Sexual Dysfunction in Female Patients with Rheumatoid Arthritis: Results of a Cross-sectional Study
Authors: Puchner Rudolf , Sautner Judith , Gruber Johann , Bragagna Elia , Trenkler Andrea , Lang Gertraud , Eberl Gabriele , Alkin Alois , Pieringer Herwig
Published: September 2018

Objective.

To evaluate the effect of rheumatoid arthritis (RA) on impairing women’s sexuality regarding motivation, activity, and satisfaction, and to assess the correlation of disease-related physical impairment within sexual functioning.

Methods.

An anonymous survey among women with RA and healthy controls (HC) using standardized questionnaires, predominantly the Changes in Sexual Functioning Questionnaire-short form (CSFQ-14). In addition, disease activity, depression, and disability were evaluated.

Results.

There were 319 questionnaires distributed to patients and 306 to HC. Of these, 235 patient questionnaires (73.7%) and 180 HC questionnaires (58.8%) were returned, of which 203 and 169 were completed, respectively. Of the patients with RA, 47.8% had a total CSFQ-14 score of ≤ 41, indicating female sexual dysfunction (FSD), as compared to 14.2% of HC (p < 0.0001). The median CSFQ-14 score was lower in patients with RA [42 points, interquartile range (IQR) 36–48] than in HC (49 points, IQR 44–54; p < 0.0001), resulting in an OR of 5.53 (95% CI 3.19–9.57; p < 0.0001). After adjustment for confounders, given a higher mean age of patients (55.2 ± 11.3 yrs) than HC (47.4 ± 11.8 yrs; p < 0.0001), the OR for FSD in patients with RA was still 3.04 (95% CI 1.61–5.75; p = 0.001). Neither the Health Assessment Questionnaire–Disability Index nor the Clinical Disease Activity Index was associated with FSD after adjustment.

Conclusion.

FSD apparently is highly prevalent in female patients with RA, affects all subdomains of sexual function, and is most likely underestimated in daily clinical practice. Of note, FSD could not be linked to disability or RA disease activity.