bluuebunny/crossref_metadata_2025 huggingface dataset:
Thromboembolic toxicity observed with concurrent trametinib and lenalidomide therapy
Authors: Chan Priya , Sabus Ashley , Hemenway Molly , Chatfield Kathryn , White Christina , Mirsky David , Foreman Nicholas , Dahl Nathan
Published: May 2022

The event-free survival of pediatric low-grade gliomas is poor, and
patients often require multiple treatment strategies. While MEK and RAF
inhibitors are efficacious in early-phase trials, not all patients
respond and many experience progression following completion of therapy.
Evaluating combination therapies that may enhance efficacy or prolong
disease stabilization is warranted. We report our institutional
experience using concurrent trametinib and lenalidomide in the treatment
of primary pediatric central and peripheral nervous system tumors. Two
of four patients using this combination therapy experienced severe
thromboembolic events necessitating discontinuation of therapy. This
combination requires further investigation, and we urge caution if used.
KAI2 -KL signalling regulates root hair elongation under magnesium deficiency by activating auxin, ethylene, and nitric oxide biosynthesis and signalling genes.
Authors: Shah Faheem Afzal , Ni Jun , Chen Xue , Tang Caiguo , Wu Lifang
Published: May 2022

Root hair elongation (RHL), which expands the absorptive surface area of
the root, is a crucial adaptation in plants for survival under magnesium
(Mg) deficient soil. Despite the significance of this trait, the
molecular mechanism in Mg starvation regulating RHL is elusive. We
demonstrated that karrikins regulate RHL under a limited supply of Mg
via crosstalk with auxin, ethylene, and NO. We used
KAI2-KL-signalling mutants, auxin, ethylene, and NO-related genes
mutants Arabidopsis and pharmacological method to investigate the
role of KAI2-KL-signalling, and its interaction with ethylene,
auxin, and NO in the process of RHL in Mg deficient conditions. Mg
deficiency could not enhance RHL in positive regulators of
KAI2-KL-signalling genes such as kai2 and max2
mutant Arabidopsis. Exogenous application of ethylene, nitric
oxide, or auxin recovered RHL of kai2 and max2 under Mg
deficiency. In contrast, exogenous supplementation of KAR
could not rescue RHL in auxin, ethylene, and
NO-related mutants Arabidopsis. In conclusion, we suggest that
karrikins signalling might regulate the RHL in response to low Mg by
acting as an upstream signalling pathway of auxin, ethylene, and NO
signalling.
Networking nutrients: how nutrition determines the structure of ecological networks
Authors: Cuff Jordan , Evans Darren , Vaughan Ian , Wilder Shawn , Tercel Maximillian , Windsor Fredric
Published: May 2022

Nutrients are a critical driver of ecological interactions (e.g.,
plant-herbivore, predator-prey and host-parasite) but are not yet
integrated into ecological networks. Ecological concepts like
nutrient-specific foraging and nutrient-dependent functional responses
provide invaluable mechanistic context to complex ecological
interactions. These concepts in turn offer an opportunity to predict
dynamic network processes such as interaction rewiring and cascading
extinction events. Here, we propose the concept of nutritional networks.
By integrating nutritional data into ecological networks, we envisage
significant advances to our understanding of ecological dynamics at
every scale from individuals to ecosystems. We summarise the potential
influence of nutrients on the structure and complexity of ecological
networks, with specific reference to niche partitioning, predator-prey
dynamics, spatiotemporal patterns and robustness. Using an empirical
example of an inter-specific trophic network, we show that networks can
be constructed with nutritional data to disentangle the drivers of
ecological interactions in natural systems. Throughout, we identify
fundamental ecological hypotheses that can be explored in a nutritional
network context, and highlight methodological frameworks to facilitate
their operationalisation.
A High Gain Flexible Receiving Antenna for Microwave Wireless Power Transmission
Authors: Li Xinyuan , Xiao Hui , Zhang Huaiqing , Xiong Han , Liu Zhewei , Peng Wenxiong
Published: May 2022

A novel high gain flexible receiving antenna is proposed, which can be
used for microwave wireless power transmission(MWPT). The antenna
consists of a three-layer toroidal structure in a generalized iterative
design with a coplanar waveguide(CPW) feed, and the radiator is
integrated on Kapton substrate. In order to improve the gain of the
antenna, an air-gap and flexible reflector are loaded at the back of the
antenna. The antenna has a peak gain of 9.51dBi at 5.8 GHz. To
characterize the stability of the antenna, the fabricated prototype uses
three configurations of 85 mm, 60 mm and 45 mm respectively. The S11 of
the antenna remains < -10dB, and the maximum harvesting
efficiency is 71.3%.
Pericyte control of blood flow in intraocular islet grafts impacts glucose homeostasis in mice
Authors: Tamayo Alejandro , Gonçalves Luciana , Rodriguez-Diaz Rayner , Pereira Elizabeth , Canales Melissa , Caicedo Alejandro , Almaça Joana
Published: May 2022

  

The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and deliver insulin and glucagon into the circulation. Long thought to be passive conduits of nutrients and hormones, islet capillaries were recently found to be densely covered with contractile pericytes with the capacity to locally control blood flow. Here we determined the contribution of pericyte regulation of islet blood flow to plasma insulin and glucagon levels and glycemia. Selective optogenetic activation of pericytes in intraocular islet grafts contracted capillaries and diminished blood flow. In awake mice, acute light-induced stimulation of islet pericytes decreased insulin and increased glucagon plasma levels, producing hyperglycemic effects. Interestingly, pericytes are the targets of sympathetic nerves in the islet, suggesting that sympathetic control of hormone secretion may occur in part by modulating pericyte activity and blood flow. Indeed, in vivo activation of pericytes with the sympathetic agonist phenylephrine decreased blood flow in mouse islet grafts, lowered plasma insulin levels and increased glycemia. We further show that islet pericytes and blood vessels in living human pancreas slices responded to sympathetic input. Our findings indicate that pericytes mediate vascular responses in the islet that are required for adequate hormone secretion and glucose homeostasis. Vascular and neuronal alterations that are commonly seen in the islets of people with diabetes may impair regulation of islet blood flow and thus precipitate islet dysfunction.
Corrosion behavior of laser-cladding NiCrBSi coating in molten aluminum alloy
Authors: Wang Qian , Li Qian , Chen Fa Qiang , Zhang Liang , Li Ji Dong , Zhang Jun Wei
Published: May 2022

In order to investigate the corrosion mechanism in molten aluminum alloy, NiCrBSi coating was prepared on H13 tool steel by laser-cladding. The coating mainly contained γ-(Ni, Fe), Cr7C3, Ni3B, and CrB. Floret-shaped CrB and dendritic Cr7C3 were uniformly distributed in the Ni-based solid solution matrix, with Ni-Ni3B network eutectics separated around them. The corrosion test results in molten aluminum alloy at 1073 K revealed that NiCrBSi coating exhibited excellent corrosion resistance, which was attributed to its boride-containing phase composition and microstructure. Borides can help prevent the coating surface from being wetted by liquid aluminum at the early stage of corrosion. With the prolongation of the corrosion time, molten aluminum alloy began to wet the coating surface and react with it to form a transition layer. However, the dense network structure formed by CrB hard phases and boron-rich eutectics can effectively prevent liquid aluminum from intruding into the interior part of the coating. Meanwhile, the raised borides at the interface can also slow down the reaction between aluminum and the surrounding Ni-based matrix. Thus, the corrosion rate was relatively slow and a transition layer with the thickness of 140 μm was formed after 150 h of corrosion, while the inferior coating and H13 substrate still remained intact.
EFFECT OF POLYCARBOXYLATE SUPERPLASTICIZERS ON THE PROPERTIES OF READY-MIX CONCRETE
Authors:   Lviv Polytechnic National University, Department of Building Production, Rykhlitska Oksana , Kropyvnytska Тetiana ,   Lviv Polytechnic National University, Department of Building Production
Published: May 2022

The article analyzes the experience of using Portland limestone cement for the production of ready-mixed concretes. It is shown that polycarboxylate superplasticizers (PCE) play a decisive role in providing required technological and construction-technical properties of concrete. The data show that the most effective PCEs for maintaining the workability of the concrete mixture over time and obtaining the required strength class of concrete are РСЕ based on modified acrylic polymers. It was found that polycarboxylate superplasticizers provide a significant water-reducing effect (ΔW/C = 38%) and was achieved compressive strength class C45/55. It is shown that such concretes are characterized by its rapid strength development (fcm2/fcm28=0.54). The ready-mix concrete with PCE was used for concreting foundations of wind turbines on the wind power plant with provide the technological properties and of reduce CO2 emissions.
ANALYSIS OF WALL MATERIALS ACCORDING TO THERMAL PARAMETERS
Authors:   Lviv Polytechnic National University, Department of Building Production, Marushchak Uliana , Pozniak Oksana ,   Lviv Polytechnic National University, Department of Building Production
Published: May 2022

Based on the analysis of energy consumption and carbon dioxide emissions of the construction industry, it is stated that the reduction of energy consumption in Ukraine is achieved through termomodernization of the existing building stock and build new buildings, which meet energy efficiency requirements. Comparison of thermal parameters of different wall materials are given. It is shown that multilayer wall constructions must be used to ensure the necessary indicators of external walls of energy efficient buildings. The use of effective wall materials allows to ensure compliance with the given temperature difference to regulatory documents and reducing of heat transfer by transmission during the heating season, solar heat gains during cooling season.
Cross-docking cargo delivery routing for guaranteed minimum period
Authors:   Lviv National University of Nature Management, Oliskevych Myroslav , Danchuk Viktor ,   National Transport University, Mastykash Oleksandr ,   Lviv Polytechnic National University
Published: May 2022

The article is devoted to the problem of effective use of cross-docking as a technology of cargo delivery with increased time requirements, which allows to resolve the contradictions of guaranteed delivery time ensuring and the efficiency of the existing fleet of trucks. The process of delivery organization is considered as the ordering on the transport network of many discrete freight flows in the form of their phases. If qualitative and / or quantitative changes do not occur from phase to phase with the flow, then the tact of such flow is constant. However, cross-docking flows change the size of the band of moving goods. Cargo can be moved as intended by any group size, which, however, is limited by the maximum and minimum values. A two-stage algorithm for solving the problem has been developed. The transport network is represented as a graph. The content of the route search problem is optimization, as it consists of multiple selections from the initial graph of arcs in the presence of restrictions on input and output flows. One needs to replace every each edge of the graph with an arc of the forward or reverse direction, or remove this edge. The criterion for the optimal solution of the problem, which is applied, is the minimum guaranteed duration of delivery of goods throughout the set of specified freight flows. At the first stage of the algorithm, the search for the shortest paths in the graph is performed, along which every given cargo flow can pass. The first stage of optimization is a linear problem of integer programming, the dimension of which is not too large. The initial data of the second stage is freight flows matrix, which is obtained as a result of optimization in the first stage. The content of the second stage of the algorithm is the solution of the equation of the balance of discrete goods flows. The balance equation means that all flows entering each peak including the sources of cargo flows of this peak have an average intensity equal to the intensity of the outgoing cargo flows from each source peak, including runoff. Due to the studied dependencies between the individual phases of the delivery process on the example of a cargo carrier on the transport network of Ukraine, the formulated restrictions and boundary conditions, the possibility of guaranteed accurate solution of a complex problem is obtained. At the same time, the shortest routes were found, reloading points were identified as well as time parameters of operation and the degree of loading of cars. According to the results of the research, a threefold increase in the productivity of the fleet of road trains with a reduction in the guaranteed delivery time by 30%.
Influence of vehicle acceleration intensity on dual-mass flywheel elements and transmission load
Authors:   Lviv Polytechnic National University, Kindratskyy Bohdan , Litvin Roman ,   Lviv Polytechnic National University, Osmak Oleksiy ,   Lviv Polytechnic National University
Published: May 2022

Modern high-torque low-speed internal combustion engines (ICEs) generate torsional vibrations close in disturbance frequency to gearboxes natural oscillation frequencies. Effective absorption of such oscillations requires a new torsional vibration damper between the internal combustion engine and gearbox design, which is implemented in the form of a dual-mass flywheel (DMF). One of the main reasons for DMF failure is its spring components destruction. The article develops mathematical and simulation (in MATLAB Simulink environment) model of a car with DMF in the period of starting, which takes into account the dependence of torque and power of the internal combustion engine on the number of the crankshaft revolutions and uneven rotation, car inertial and stiffness parameters, road resistance. It is established that when the car starts in first gear, the maximum load on spring components of DMF and transmission occurs at the initial moment of clutch engagement and exceeds the maximum effective torque of the internal combustion engine 1.6 times, has a pronounced oscillatory character and stabilizes as the car accelerates. With smooth acceleration of a car, when torque of internal combustion engine reaches, but does not exceed its maximum value of 250 N‧m, elastic moment in transmission components is stabilized at 230 N‧m. During intensive acceleration and transition through the extremum on torque curve of internal combustion engine on number of crankshaft revolution, the maximum DMF spring components and transmission load initially doesn’t change significantly, but reduces the duration of oscillatory processes and elastic moment of 160 N·m after attenuation of oscillations. A similar nature of stress changes is observed in the elastic links of DMF, which eventually leads to their fatigue failure and DMF failure. To increase a DMF service life, it is advisable to accelerate a car when moving intensively, bringing a number of revolutions to a value that is located at the extreme of torque of internal combustion engine on its performance characteristic, followed by switching to the next gear.
A Study of the Poetry of the Pre-Islamic Poet al-Hutaya’ with a Particular Reference to His poem,’Watawi thalathe’
Authors: S. Sultan Sabbar
Published: May 2022

The present paper often called “mukhadhram” (living in two eras (Jahiliyat or pre-Islamic and Islamic) and the difficulty he encountered in reaching a compromise between the norms ,conventions and priorities of these two eras. Jarwal bin Aws bin Malik al-Abbassi, who is known by the nickname al-Hutaya’ (600-678) is the pivot of this study. The significance of the current study lies in highlighting his favorite topics, especially eulogy and satire, his allergic relationship with people and his fellow poets and his self-centered views. Also it pays much attention to his type of poetry and its characteristic tone. The approach used here is biographical, albeit sounding outmoded or outdated, i.e., in that it tries to study his poetry in the light of his experiences and different situations he has passed through and their impacts on the type of poetry he has written. This will be followed by a translation (conducted by the present researcher) of his magnum opus ‘ watawit halathe’ (starving for three days) which he wrote in his last year. The formal and thematic aspects of the poem will be discussed. A final assessment of this poem will be provided as a work that has been rightly classified as a landmark in the poet’s career.
Hermia’s Loss of Paradise in Midsummer Night’s Dream: Seeing the Other
Authors: Ziyad Alsharadgeh Samer
Published: May 2022

This article analyses the gap between the young (Hermia and Lysander) and old (Egeus and Theseus) generation in Shakespeare’s Midsummer Night’s Dream from Jung’s (2012) perspective of individuation. Individuation is a process where one gains sense of singular identity separate from the influence of others in a society. This gap between the young and old generation has always been a bone of contention in every age. This article tries to highlight the reasons and solutions necessary to achieve harmony without breaking the bond of respect. Hermia in Midsummer Night’s Dream is a young Athenian girl who falls in love with Lysander, whom her father Egeus dislikes. She cannot marry Lysander without the consent of her father. The gap between the old and new generations comes to the fore. Hermia loses her paradise because she wants to marry Lysander while her father is against this marriage. Thus, a conflict between the individual’s interests starts. This conflict resolves through the process of individuation, where all characters reconcile their differences through a moment of self-discovery that leads to the cultivation of a character, rooted in individuality transcending mere social roles and the expectations of society. This article projects the value of human freedom against suppressing values based on a personal desire to dominate and rule. It also highlights the importance of self-certainty and its conscious integration based on the principle of mutual respect necessary for social dynamism.
Directions of seaport technological rules development
Authors: Kuznetsov Alexander Lvovich , Sampiev Adam Mihaylovich , Semenov Anton Denisovich , Kirichenko Alexander Viktorovich
Published: May 2022

The article highlights the design process aimed to develop a non-existing object, which should correspond to all the requirements. As far as the physical creation of an object is started only after finishing the design process, the whole procedure includes discussing different models and information. The result of sea terminals design is the documentation which consists of not only the necessary for construction and exploitation information, but also almost all physical, operational, exploitation and financial parameters of the object. The elements of behavior research, i.e. exploration of the output parameters reaction to the change of input ones and the data that were calculated on the previous steps of the design process, is a necessary part of each next step. The variation of requirements to the precision, sustainability and specification of data on different steps of design require to use different in complexity and precision models to analyze them. The capitalization of infrastructural objects of sea transport, the acceptance of liquidity and the scale of social-economic impact on the society define the special requirements to this branch of activity, which are applied in strict regulation and formulation of rules of all design processes. It has been stated that the active rules define the methods of sea terminals design, but this definition has been unchanged for a long time. The great evolution of nature, structure and volumes of data bring a conflict with the documental requirements to the calculations. There are developed the general rules of mathematical modelling used as an instrument of design on different steps of sea terminals design. There is carried out a brief content analysis of the typical steps of a design process, which allows to correspond the consequence of technological design stages with using the statistical modelling and queueing theory design methods. It also includes the description of a new concept of simulation modelling, which allows to connect gnoseological advantages of this approach with universality of traditional methods. Saving the universality and objective process of consequent adequacy provement of all the described models allow to put a question of utilization of this instrument into the general rules and recommendations of sea terminal design.
Epistemic communities in political ecology: critical deconstruction or radical advocacy?
Authors: Desvallées Lise , Arnauld de Sartre Xavier , Kull Christian
Published: May 2022

Recent political ecology scholarship appears to be turning towards de-growth agendas and radical activism, notably in Europe. These postures diverge somewhat from the 'classical' political ecological tradition rooted in a critical deconstruction of dominant ideas and actors and field-based analyses. We posit a heuristic distinction between these two impulses. While both are based in critiques (Robbins' 'hatchet'), as far as the 'seed' one impulse leans more towards critical 'deconstruction', the other towards radical 'advocacy.' Through a systemic review of the political ecology literature, we seek to identify and characterize these impulses, link them to epistemic communities of knowledge production, and explain these trends. Our review incorporates qualitative analysis of key texts, as well as quantitative bibliometric and content analysis of Scopus-indexed publications referring to political ecology (1951-2019) and abstracts from all the articles published in Journal of Political Ecology, from POLLEN conferences in Europe (2016, 2018) and from DOPE conferences in the US (2013-2019). Among other things, we find that even if political ecology has long been divided between deconstructivist and advocacy approaches, the second is becoming preeminent since many political ecologists are taking a radical turn, with strong theoretically rooted attacks on the capitalist system taking place. Some political ecological research increasingly positions itself in socio-political debates related to the greening of unjust societies in the First World. This is most prominent in continental European academia (and some English universities), where political ecology is institutionally more marginal; in the remaining British and North American universities, the more deconstructivist impulse is more dominant but also more pluralistic in its orientations.
Risk Level of Design and Procurement Factors Causing Construction Waste Generation
Authors: Bachayo A. , Memon A. H. , Hussain M. , Rahman I. A. , Ahmed S. J.
Published: May 2022

Construction waste is a global concern among the practitioners and has got attention of the researchers for many years. This issue is serious in construction industry of Pakistan also and various researchers have contributed in addressing it. This paper identified design and procurement related factors and assessed their risk level in causing construction waste. Data was collected through questionnaire survey amongst the practitioners from client consultants and contractors working on construction projects in Karachi and Hyderabad division of the Sind province. A total of 72 completed questionnaire forms were analysed and the results shows that 8 of the 20 factors are highly important factors and fall in the red zone of the risk matrix. It was also observed that last minute client requirements is reported as most important factor in design related issues while “items not in compliance with specification” is the most risk factor in the category of the procurement. Besides these, “last minute client requirements” and “Mistakes in quantity surveys” are the key factors which have significant effect on project cost. The findings of this study will be helpful for the practitioner to improve design and procurement quality for controlling the waste generation.
Static Parametric Stress-Strain Analysis for Asphaltic Concrete Core of Rockfill Dams
Authors: Shiravi Shahram
Published: May 2022

This study was conducted to investigate the effect of variations in the asphaltic concrete core Rockfill dam geometric parameters on the core behavior at different upper, middle, and lower points under two-dimensional static stress-strain analysis. The mentioned analysis was performed using SIGMA/W software. In the modeling and analysis process, the geometry of a large number of dams constructed around the world was studied and many numerical models with variations in eight classes of height, three dams upstream/downstream slope modes, and three different asphaltic core positions and thicknesses on a rigid foundation were created and analyzed. In addition, for each of the above models, four dam operation stages including “End of Construction”, “Full Reservoir”, “Half-Full Reservoir”, and “Rapid Drawdown” were considered. The results show, in four different stages of construction and impounding and three different slope modes, the maximum stress as well as horizontal and vertical displacements at the upper, middle, and lower points of the core increase with increasing height. In all models, increasing upstream and downstream slopes results in an increase in the amount of vertical displacement for all construction and impounding stages at the upper, middle, and lower points of the core. In the middle and lower points of the core, with increasing height, the amount of deviatoric stress increases for all construction and impounding conditions. In addition, for all operation cases, the maximum strain increases in all points of the vertical and tilted cores as the core thickness increases. Additional results are presented in the next sections.
Regime of Contraventions and Sanctions Related to Vat Tax Declarations
Authors: Boiţă Marius , Dumiter Florin Cornel , Ajtay Eduard
Published: May 2022

In order to better collect taxes and combat fraud and tax evasion by strengthening the national legislative framework, a number of regulations and reports have been put in place for monitoring the declaration of all economic operations between partners in a regulated free market. The provisions adopted in the field of taxation in conjunction with the accounting report provided, respectively reported by the entities to the tax authorities, are applied for the correct assessment of their activity in order to combat the practices of tax avoidance, tax fraud, and tax evasion. This study does not analyze the fiscal policy as a whole, this paper addresses the regime of contraventions and sanctions, as well as the repercussions of non-declaration or incomplete or erroneous declaration of the Recapitulative Statements on intra-Community supplies/acquisitions/services (code D390) and Informative declarations on deliveries/services and purchases made in the national territory (code 394), related to value-added tax.
Competencies of Graduates – An Industry Expectation
Authors: Czerwińska-Lubszczyk Agnieszka , Grebski Michalene , Jagoda-Sobalak Dominika
Published: May 2022

Changes in the environment of industry may affect the expectations related to the competencies of the employees. Changes to the education system and curricula may be required. The main purpose of this research paper was to analyze the expectations of the industries related to competencies of graduates of engineering programs. The paper presents preliminary research. The survey was conducted at twenty-eight companies within the area of technical university in Poland. Based on the survey, data was collected related to the level of preparation of engineering graduates as well as the industry expectations related to the preparation of engineering graduates. This was done for the purpose of determining the gap between industry expectations and the level of preparation of the engineering graduates. Enterprises expect a wide range of competences from engineering graduates. The most important areas of competence included soft competences and practical knowledge and skills. The biggest gap between industry expectation and graduate’s preparation are the soft skills. Recommendations were suggested which would be incorporated in the engineering curriculum for the purpose of continuous quality improvement.
Efficient Practices of Cognitive Technology Application for Smart Manufacturing
Authors: Sira Mariya
Published: May 2022

Cognitive manufacturing (CM) provides for the merging of sensor-based information, advanced analytics, and cognitive technologies, mainly machine learning in the context of Industry 4.0. Manufacturers apply cognitive technologies to review current business metrics, solve essential business problems, generate new value in their manufacturing data and improve quality. The article investigates four powerful applications for cognitive manufacturing and their influence on a company`s maintenance. The study aims to observe kinds of cognitive technology applications for smart manufacturing, distinguish their prospective gains for manufacturers and provide successful examples of their adoption. The analysis is based on the literature and report review. Assessment of the cases of technology adoption proves that cognitive manufacturing provides both enhanced knowledge management and helps organizations improve fundamental business measurements, such as productivity, product reliability, quality, safety, and yield while reducing downtime and lowering costs.
Sehnsucht as Signpost: The Autobiographical Impulse of C. S. Lewis
Authors: Lazo Andrew
Published: May 2022

For half a century, readers of C. S. Lewis had only two problematic and at times obscure spiritual autobiographies (The Pilgrim’s RegressandSurprised by Joy) to use in attempts to understand Lewis’s journey to faith through what he called Joy, Sehnsucht, or longing. Both books, though important and full of key insights, in some ways hid more than they revealed. Recent discoveries, however, have widened the arc of autobiography. Lewis’s landmark pre-Christian account of his conversion to theism, ‘Early Prose Joy’, published in 2013, monumentally widened and deepened our understanding of Lewis’s spiritual journey to faith. And the fragmentary poem ‘I Will Write Down the Portion that I Understand’ also adds significant insight, at least into Lewis’s composition process of grappling with conversion. Insightful recent scholarship by Alister McGrath suggests widening the scope of what we consider spiritual autobiography in Lewis to includeA Grief Observed; this idea opens the door to a broader view of how autobiography functions both in Lewis’s compositional life and in the categorization of his writings. This essay accepts that invitation, finding clear autobiographical efforts to capture the role of Joy in Lewis’s early poetry, includingDymer, and in his late novelTill We Have Faces. That last book, written with soon-to-be-wife Joy Davidman, serves crucially to change the focus of Lewis’s spiritual autobiographies from Joy to love. By thus expanding and exploring Lewis’s autobiographical arc, this essay brings to light an almost teleological understanding of love and the central theme of Lewis’s life and work.
Chronic Non-Cancer Pain: New Definitions, New Paradigms and Old Myths
Authors:   University Of Bari “Aldo Moro”, Puntillo Filomena
Published: May 2022

Chronic pain is a highly prevalent phenomenon that involves biological, psychological, and social aspects with negative effects on function, mood, and quality of life. The International Association for the Study of Pain (IASP) advocates updating the current definition of chronic pain to better recognize the diversity and complexity that is difficult to capture in a brief definition.
Methods and Initial Findings of the Observational Study of Ostomy Consumers Registry
Authors:   Hollister Incorporated, Libertyville, Illinois, Malandrino Renee , Goldberg Margaret , Riemer Michael , Salvadalena Ginger , Urwin Sally Jane
Published: May 2022

BACKGROUND: Longitudinal patient-reported data are limited for people living with an ostomy. PURPOSE: The Observational Study of Ostomy Consumers (OSO) registry collects data from individuals living with an ostomy. METHODS: Self-reported data were collected via repeated electronic surveys completed by adults living with an ostomy in the United States (US) and United Kingdom (UK). RESULTS: Baseline data, collected between October 2018 and February 2021, were available for 299 individuals from the US (77.9%) and UK (22.1%). Most participants reported using a 2-piece pouching system (55.5%) rather than a 1-piece system (44.4%), and using a convex barrier (54.4%) or flat barrier (44.3%). The most commonly reported barrier wear times were ≥ 3 to < 4 days for 36.6% of participants in the US and ≥ 1 to < 2 days for 42.4% of participants in the UK. Despite self-reports of leakage and peristomal skin conditions, quality of life remained positive. A majority of participants (92.0%) reported being very satisfied or somewhat satisfied with their ostomy product. CONCLUSION: The Observational Study of Ostomy Consumers registry allows for a continuous data stream that can be mined to help understand the patient experience over time. Understanding patient experiences will help to inform clinical practice and research, health care utilization, and product innovation.
Le discours journalistique : entre discours historique et fiction. Vers une sémiotique de l’événement
Authors: Lozano Hernández Jorge
Published: May 2022

Une typologie des discours pourrait situer le discours journalistique entre l’historique et le fictionnel. En considérant sa proximité et sa distance par rapport à ces deux types de discours, nous pourrions discuter de la construction de l’« événement », compris comme une configuration discursive. De nos jours, le discours journalistique peut être considéré comme prédominant dans l’histoire du présent (Zeitgeschichte). Un bon exemple des stratégies discursives dans chacun d’eux – histoire et fiction – est fourni par le cas référentiel de Wikileaks.
Modas, modos y maneras de la violencia visual de ISIS
Authors: Martín Miguel
Published: May 2022

Entre 2014 y 2017, El Estado Islámico (Daesh) asesinó a más de 800 personas ante sus cámaras. La mayoría de los asesinados eran sirios e iraquíes de fe musulmana condenados a morir públicamente. De todas estas ejecuciones, más de la mitad contenían referencias a la cultura audiovisual occidental. Sin embargo, el éxito de la producción propagandística de la organización no sólo se reflejó en la popularidad que alcanzaron sus vídeos a escala mundial, sino también en su “eficacia icónica”, ya que a través de ella la organización fue capaz de transformar semánticamente el terrorismo y convertirlo no sólo en algo amenazante, sino también en un producto de consumo masivo que además inspiró a quienes lo consumen a crear nuevos contenidos relacionados con el Estado Islámico. De este modo, el ISIS ha conseguido configurar un eficaz discurso visual en torno a la violencia, capaz de despertar simultáneamente pasiones como el miedo o la fascinación. Entre las principales estrategias utilizadas se encuentran los recursos relacionados con la ficción, así como las técnicas para producir un “efecto de realidad”. También destaca la forma particular de representar la muerte, en la que predomina una “somática del ver morir” sobre una “somática del morir”.
Narco-mensajes y fotografía. La hipotiposis como recurso en la expresión de la violencia
Authors: SOLÍS ZEPEDA María Luisa
Published: May 2022

Este trabajo adopta un punto de vista general sobre la violencia en México, recurriendo a ciertas consideraciones filosóficas. Sobre esta base, propone un análisis de las prácticas violentas emanadas del tráfico de drogas, y en particular de los “narco-mensajes”, así como de su presentación y puesta en escena por medio de la fotografía, gracias a un recurso retórico particular: la hipotiposis.
L’Adresse lyrique
Authors: Culler Jonathan
Published: May 2022

La structure fondamentale de la poésie lyrique serait l’adresse triangulée (triangulated address): le lecteur donne voix à un discours qui s’adresse aux lecteurs par l’intermédiaire d’un tiers – quelqu’un ou quelque chose qui est adressé. La version la plus frappante de ce phénomène – figure qui résume tout ce qu’il y a de plus prétentieux et de mystificateur dans la poésie lyrique – serait la figure vatique de l’apostrophe: à savoir, l’interpellation d’un interlocuteur fictif (une urne, un oiseau, la Mort, la Beauté). L’adresse directe faite au lecteur est assez rare, et comporte souvent ce qu’on pourrait appeler un «vous flou» qui désigne le lecteur, ou tout le monde, ou encore le poète lui ou elle-même. C’est l’adresse lyrique qui fait du poème un événement.

Mots-clés: ADRESSE. APOSTROPHE. EXPRESSION. INVOCATION. TRIANGULATION.
Predicting RP-LC retention indices of structurally unknown chemicals from mass spectrometry data
Authors: Boelrijk Jim , Samanipour Saer , van Herwerden Denice , Ensing Bernd , Forré Patrick
Published: May 2022

Non-target analysis combined with high resolution mass spectrometry is considered one of the most comprehensive strategies for the detection and identification of known and unknown chemicals in complex samples. However, many compounds remain unidentified due to data complexity and limited structures in chemical databases. In this work, we have developed and validated a novel machine learning algorithm to predict the retention index (r$_i$) values for structurally (un)known chemicals based on their measured fragmentation pattern. The developed model, for the first time, enabled the predication of r$_i$ values without the need for the exact structure of the chemicals, with an $R^2$ of 0.91 and 0.77 and root mean squared error (RMSE) of 47 and 67 r$_i$ units for the Norman and amide test set, respectively. This fragment based model showed comparable accuracy in r$_i$ prediction compared to conventional descriptor-based models that rely on known chemical structure, which obtained a $R^2$ of 0.85 with and RMSE of 67.
Hydrogen-Induced Restructuring of a Cu(100) Electrode in Electroreduction Conditions
Authors: Zhang Zisheng , Wei Ziyang , Sautet Philippe , Alexandrova Anastassia N
Published: May 2022

The rearrangement of Cu surfaces under electrochemical conditions has been demonstrated to play a key role in the surface activation for major electrocatalytic reactions. Despite the extensive experimental insights from surface-sensitive spectroscopic and microscopic methods, their spatial and temporal resolution are far from ideal. Theoretical investigations have also been challenged by the diversity of restructuring configurations, surface stoichiometry, adsorbate configurations, and the effect of electrode potential. Here, we tackle this complexity of the electrochemical interface by grand canonical DFT and global optimization techniques, which explore the chemical space of Cu(100) restructuring with varying applied potential and adsorbate coverage from first principles. We show that electroreduction conditions cause the formation of a shifted-row reconstruction on Cu(100), induced by hydrogen adsorption. The simulated STM images of the calculated reconstructed structures agree with experimental in situ STM images, which validates our results. The found shifted-row reconstruction is initiated and stabilized 1/6 ML H coverage since this weakens the Cu-Cu bonds between top- and sub-layer and at 1/3 ML fills all the created 3-fold hollow sites with H adsorbates. Different statistical models are used to study the potential- and pH-dependence of the surface stability diagram. The kinetics and dynamics of surface atoms are studied with BOMD simulations, and their dependence on H coverage and initial configuration is discussed. This manuscript provides rich insight into surface restructuring in electroreduction conditions, which is required for the understanding and rational design of Cu-based materials for electrocatalytic processes and beyond.
Constitutionally selective dynamic covalent nanoparticle assembly
Authors: Marro Nicolas , Suo Rongtian , Naden Aaron B. , Kay Euan R.
Published: May 2022

The future of materials chemistry will be defined by our ability to precisely arrange components that have considerably larger dimensions and more complex compositions than conventional molecular or macromolecular building blocks. However, exerting structural and constitutional control in the assembly of nanoscale entities presents a considerable challenge. Dynamic covalent nanoparticles are emerging as an attractive category of reaction-enabled solution-processable nanosized building block through which the rational principles of molecular synthetic chemistry can be extended into the nanoscale. From a mixture of two hydrazone-based dynamic covalent nanoparticles with complementary reactivity, specific molecular instructions trigger selective assembly of intimately mixed heteromaterial (Au–Pd) aggregates or materials highly enriched in either one of the two core materials. In much the same way as complementary and orthogonal reactivity is exploited in synthetic molecular chemistry, chemospecific nanoparticle-bound reactions dictate building block connectivity, and kinetic regioselectivity regulates the detailed composition of the materials produced. Selectivity, and hence aggregate composition, is sensitive to several system parameters. By characterizing the nanoparticle-bound reactions in isolation, kinetic models of the multiscale assembly network can be constructed. Despite ignoring heterogeneous physical processes such as aggregation and precipitation, these simple kinetic models successfully link the underlying molecular events with the nanoscale assembly outcome, guiding rational optimization to maximize selectivity for each of three assembly pathways. With such predictive construction strategies, we can anticipate that reaction-enabled nanoparticles can become fully incorporated in the lexicon of synthetic chemistry, establishing a synthetic science that incorporates molecular and nanoscale components with equal proficiency.
Fluorinated Aliphatic Diazirines: Preparation, Characterization, and Photolabeling Studies
Authors: Kornii Urii , Shablykin Oleg , Tarasiuk Taras , Stepaniuk Oleksandr , Matvienko Vitaliy , Aloshyn Danylo , Zahorodniuk Nataliia , Mykhailiuk Pavel
Published: May 2022

The previously unknown difluoromethyl- and the previously neglected trifluoromethyl-aliphatic diazirines were synthesized and characterized. Model photolabeling experiments and biological studies revealed that the stable trifluoromethyl-aliphatic diazirines could indeed be safely used as photoaffinity labels, while the labile difluoromethylated analogues - could not.
Different Hemodynamic Types of Preeclampsia Observed Under Ultrasonic Cardiac Output Monitor (USCOM): A Report of Two Cases
Authors: Ma Zhen
Published: May 2022

Preeclampsia is a serious and uncommon complication of pregnancy, which affects 5% to 7% of pregnancies and is associated with maternal and fetal adverse outcomes. Moreover, preeclampsia is a polymorphic disease with different hemodynamic types, thus requiring different therapeutic strategies. As a hemodynamic tool, the ultrasonic cardiac output monitor (USCOM) is useful in the detection of preeclampsia as early as the 5th to 16th week of gestation, with abnormal hemodynamic indicating preeclampsia. Although blood pressure (BP) rises in preeclamptic patients, it is not a sensitive indicator for the diagnosis of preeclampsia. However, hemodynamic may change in the 5th to 11th week of gestation. In this paper, the hemodynamic types of two cases were reported using USCOM. The SV, CO, and SVRI values were significantly different in both the cases, indicating the patients had different types of preeclampsia. The hemodynamic parameters were more useful than blood pressure for managing the two cases. Moreover, the mother and fetal were safe after treatment. If preeclampsia had been assessed only from the perspective of BP, the two cases would have been diagnosed as having mild hypertension, and we would not be able to determine the severity. USCOM allowed the identification of preeclampsia-associated hemodynamics and defined individualized therapeutic targets, which cannot be identified by BP alone.
Sistematización de experiencias académicas de la Facultad de la Pedagogía, Universidad Técnica Luis Vargas Torres
Authors: Naranjo Vaca Gregory Edison , Puya Lino Aníbal , Gorina Sánchez Alexander , Rodríguez Caballero Giselle Aurelia , Caballero Rodríguez Ana Norvis , Caballero Rodríguez Tamara , Tabares Stable Ana Luisa , Bestard Revilla Alina , Romero León Manuel Alejandro , Martínez Aguilera Cynthia , Medina Bueno Darlenis , Casero Dupuy Onel , Rabilero Sabates Hilda Rosa , Gómez Abeledo Guadalupe , Chila Ortiz Hernán Vinicio , Tapia Sosa Hugo David , Caicedo Perlaza Luis Copérnico , Valverde Medina Luzmila María , Ulloa Espinoza Cecilia Mariana , Lima Cazorla Lázaro , Rivas Rosero Juan , García Caicedo Vilma Viviana , Mina Barahona Sonia Malia , Martínez Gil Libeth , Batalla Benavides Celia Verónica , Ojeda Morán Mauricio , Márquez Ramírez Jéssica , Posso Martínez Rosa Romelia , Bartolomé Llorente Daniel
Published: May 2022

A la hora de pensar las innovaciones pedagógicas, políticas educativas y procesos de superación docente de formación profesional continua, frente a las exigencias de la contemporaneidad ya nadie pasa por alto la problemática de la formación docente en lo que corresponde a su calidad y pertinencia. Los modelos pedagógicos, configurados en la modernidad hacia fines del siglo XIX en América Latina, conservan una huella de su origen: la centralidad del docente, concebido como técnico y recurso educativo insustituible. Situación que frente al avance de las Nuevas Tecnologías y Comunicación ha empezado a ceder y a comprenderse que el estudiante es el que constituye el eje central para la construcción del conocimiento constituyendo un proceso de transformación trascendental. Estas transformaciones generan no sólo nuevas necesidades formativas para los estudiantes de pedagogía sino también para los docentes, quienes enfrentan la tarea mediadora de saberes científicos disciplinares y de forma simultánea su propio desarrollo profesional impulsado desde el trabajo metodológico guiado desde materias principales integradoras en la que es aun insuficiente la calidad y excelencia. La estrategia de la Feria de Ciencias Pedagógicas que nace de la propuesta de tesis de un docente que cursó estudios de formación doctoral en el extranjero, ha servido para encauzar la actividad investigativa del claustro docente de la Facultad de la Pedagogía, la que a su vez se corresponde con la formación docente de los estudiantes universitarios. Por consiguiente, resulta ser coincidente con lo que constituye una prioridad para los estados y organizaciones internacionales como la Organización de Naciones Unidas para la Educación, la Ciencia y la Cultura (UNESCO) y la Organización Regional de Educación Superior en América Latina (CRESAL), las que dedican esfuerzos al estudio de sus particularidades.