bluuebunny/crossref_metadata_2025 huggingface dataset:
The application of artificial neural networks for the optimization of coagulant dosage
Authors: Griffiths K. A. , Andrews R. C.
Published: December 2011

Filtration is the final physical barrier preventing the passage of microbial pathogens into public drinking water. Proper pre-treatment via coagulation is essential for maintaining good particle removal during filtration. To improve filter performance at the Elgin Area WTP, artificial neural network (ANN) models were applied to optimize pre-filtration processes in terms of settled water turbidity and alum dosage. ANNs were successfully developed to predict future settled water turbidity based on seasonal raw water variables and chemical dosages, with correlation (R2) values ranging from 0.63 to 0.79. Additionally, inverse-process ANNs were developed to predict the optimal alum dosage required to achieve desired settled water turbidity, with correlation (R2) values ranging from 0.78 to 0.89.
Using smart meters to identify social and technological impacts on residential water consumption
Authors: Beal Cara , Stewart Rodney A. , Spinks Anneliese , Fielding Kelly
Published: December 2011

Studies have shown that householders' perceptions of their water use are often not well matched with their actual water use. There has been less research, however, investigating whether this bias is related to specific types of end use and/or specific types of socio-demographic and socio-demographic household profiles. A high resolution smart metering study producing a detailed end use event registry as well as psycho-social and socio-demographic surveys, stock inventory audits and self-reported water diaries was completed for 250 households located in South-east Queensland, Australia. The study examined the contributions of end uses to total water use for each group identified as ‘low’, ‘medium’ or ‘high’ water users. Analyses were conducted to examine the socio-demographic variables such as income, percentage of water efficient stock, family size and composition, that characterise each self-identified water usage group. The paper concludes with a discussion of the general characteristics of groups that overestimate and underestimate their water use and how this knowledge can be used to inform demand management policy such as targeted community education programmes.
Web enablement of a Water Safety Plan via the municipal-based electronic Water Quality Management System (eWQMS)
Authors: de Souza P. F. , Burgess J. E. , Swart M. , Naidoo V. , Blanckenberg A.
Published: December 2011

Despite a good legislative framework, South Africa faces significant challenges in the sustainable provision of adequate and safe water services. To improve the situation, South Africa's Department of Water Affairs (DWA) and other water sector partners undertook initiatives to assist municipalities with operation and management of water services. By way of example, in 2006, the municipal engineering oriented electronic Water Quality Management System (eWQMS) was implemented, providing municipalities with a platform for loading drinking water quality data and tracking performance of key water services management functions. Following this in 2008, DWA introduced an incentive-based regulatory programme, Blue Drop Certification (BDC), and the associated regulatory drinking water quality information system, the Blue Drop System (BDS) which is, for example, populated with data loaded by municipalities onto eWQMS. An integral part of BDC is the development of Water Safety Plans (WSPs). Due to the challenges faced by municipalities in developing WSPs, the Water Research Commission (WRC) saw a need to assist municipalities, and subsequently a generic Water Safety Plan for Small Community Water Supplies was developed. The WRC also saw the need to develop an easy-to-use WSP tool for municipalities. The eWQMS was selected as the platform for making the tool available. This paper presents the development of a web-enabled WSP tool on the eWQMS which ultimately will provide the information to the BDS.
Evaluation of fluorescence excitation–emission and LC-OCD as methods of detecting removal of NOM and DBP precursors by enhanced coagulation
Authors: Wassink J. K. , Andrews R. C. , Peiris R. H. , Legge R. L.
Published: December 2011

Bench-scale tests were conducted to evaluate enhanced coagulation as a method for removing natural organic matter (NOM) from a surface water to reduce the formation of disinfection by-products (DBPs). Aluminium sulphate (alum) and two polyaluminium chloride (PACl) coagulants were used, as well as alum with pH depression. Using a PACl coagulant alone or alum with pH depression was shown to attain 35% removal of TOC at lower dosages (31 and 29 mg/L, respectively) when compared to the use of alum alone (43 mg/L). In addition to TOC and UV254, a fluorescence excitation–emission matrix (FEEM) approach and liquid chromatography–organic carbon detection (LC-OCD) were used to further characterize the removal of NOM in both untreated and filtered waters. Principal component analysis of FEEM was able to identify the presence of humic-like substances (HS), protein-like substances (PS), and colloidal/particulate matter (CPM); HS were found to have a close correlation with TOC and UV254. LC-OCD enabled the quantitative detection of hydrophobic and hydrophilic DOC; the latter was further separated into five components, the largest of which was HS. Strong linear correlations were calculated between TOC, UV254, HS, and hydrophilic DOC (r2 > 0.96); these parameters were also found to be closely correlated with the formation of trihalomethanes (THMs, r2 > 0.78) and haloacetic acids (HAAs, r2 > 0.92). Linear correlations with THMs and HAAs indicated that FEEM and LC-OCD provide good measures of DBP precursors when compared with TOC and UV254.
Structural and magnetic properties of mechanochemically synthesized nanosized yttrium titanate
Authors: Barudzija Tanja , Gusev Alexey , Jugovic Dragana , Marinovic-Cincovic Milena , Dramicanin Miroslav , Zdujic Miodrag , Jovalekic Cedomir , Mitric Miodrag
Published: December 2011

Nanosized perovskite YTiO3 with the mean crystallite size of 18 nm was
synthesized for the first time by mechanochemical treatment. The
mechanochemical solid state reaction between commercial Y2O3 powder and
mechanochemically synthesized TiO powder in molar ratio 0.5:1 was completed
for 3 h in a high-energy planetary ball mill in argon atmosphere. The
heating in vacuum at 1150 ?C for 12 h transforms nanosized YTiO3 to a
well-crystallized single-phase perovskite YTiO3. Both samples were
characterized by X-ray diffraction (XRD) and thermogravimetric (TGA/DTA)
analyses, as well as superconducting quantum interference device
magnetometer (SQUID) measurements.
A Learning, Research and Development Framework to Design for a ‘Holistic’ Learning Experience
Authors: Carroll Fiona , Kop Rita
Published: December 2011

The design of experiences and, in particular, educational experiences is a complex matter and involves not only using effective technologies and applying cognitive triggers, but there is a need to think outside the box in order to also design for the affective dimension of human experiences; the impressions, feelings and interactions that a learner might/could have with the online content and technology. The purpose of this article is to delve deep into this complex entity and, in doing so, to identify how one might approach designing for ‘holistic’ educational experiences. The article presents a case study describing the journey of a group of learning technologists and educators through the design and development phases of an action research online ABCD module, and it highlights the learner's experiences. It discusses the development of a learning, research and development framework to support the ABCD learning experience and, in particular, what was actually required to undertake the design for this learning experience. In summary, the article reports on a learning, research and development framework that provides solutions and support to a number of aspects involved in the design of holistic learning experiences and, in particular, the often neglected, yet complex, issues around experience design.
Blended Learning: Perspectives on Mixing Online and Offline Communities of Enquiry
Authors: Rix Robert W.
Published: December 2011

Blended learning is increasingly introduced in classrooms worldwide. Nonetheless, studies are not unanimous as to its impact on student performance and its benefits to enhancing the learning experience. In this article, it is argued that a focused approach, taking into account the particular requirements of the course and the students' qualifications, is necessary to evaluate the effectiveness of blended learning. The article presents a case study of a first-semester university course which examines the effects of ‘blending’, such as mixing oral and written discourse, and its significance for the community of enquiry. In the final section of the article, three particular blend strategies are tested and evaluated. It is concluded that some types of exercises are usefully ‘blended’, while others may conveniently qualify for online work only.
Erysipelas in breast cancer patients after the radical mastectomy
Authors: Matijasevic Miodrag , Dekic Natasa , Kolarevic Daniela , Milosevic Snezana , Tomasevic Zorica , Jurisic Vladimir
Published: December 2011

Erysipelas is a bacterial cellulitis usually associated with Streptococcal infection. It may appear as a complication following mastectomy and radiotherapy for breast cancer. The study involved 17 cases of erysipelas of the upper limbs with a median age of 62 years. Here we described the clinical, therapeutic and evolutionary aspects of erysipelas. Our results indicated that the erysipelas appeared with an average of 9 years after mastectomy and was recurrent in three patients (17.64%). It is associated with obesity in 42% and arterial hypertension in 52.9% of patients with breast cancer after radical mastectomy. Breast cancer patients in advance stages of disease at presentation (T2+ T3) are significantly more subject to erysipelas in comparison to those patients with locoregional stage of disease at presentation (T1), Mann Whitney U-test, (p<0.05). All patients had complete response to antibiotics. The recurrence occurred in 2 patients (11.76%) who underwent radiotherapy with adjuvant tamoxifen and in one patient who underwent chemotherapy and radiotherapy combined. Based on these results it is possible to suggest that patients who received radiotherapy may have an additional risk factor for developing lymphedema and erysipelas
Set Up to Fail: The Unintended Consequences of Multiple Bail Conditions
Authors: Sprott Jane B. , Myers Nicole M.
Published: December 2011

Bail conditions are placed on youths in an effort to ensure they return to court and to reduce danger to the public by constraining the behaviour of the accused in the community. These conditions, however, may have the unintended consequence of setting youths up to accumulate further criminal charges of failing to comply with a court order. The present study tracked a random sample (N=225) of youths who were held for bail hearings and ultimately released from a large Toronto court. Although ultimately close to half the sample had all charges related to the bail hearing withdrawn, close to a third of the sample were charged with failing to comply with conditions of release. Those who were subject to a bail order for a relatively long time and had numerous bail conditions were most likely to accumulate new charges of failing to comply.
Dorsolateral onlay urethroplasty for long segment anterior urethral stricture: outcome of a new technique
Authors: Habib AKMK , Alam AKMK , Amanullah ATM , Rahman H , Hossain AKMS , Salam MA , Kibria SAMG
Published: December 2011

Conventional dorsal onlay urethroplasty requires circumferential mobilization of the urethra which might cause ischemia of the urethra. The present study was conducted to determine the feasibility and short term outcomes of applying dorsolateral free graft to treat anterior urethral stricture by unilateral urethral mobilization approach. This hospital based prospective interventional study was conducted in the Department of Urology, Bangabandhu Sheikh Mujib Medical University, Dhaka, from July, 2009 to December, 2010. Total 30 patients with long-segment anterior urethral strictures were selected and treated by a dorsolateral free buccal mucosa graft. The test statistics used to analyse the data were Chi-square (Χ2) test and Student’s t-Test. For all analytical tests, the level of significance was set at 0.05 and p <0.05 was considered significant. After 6 months follow up results were prepared. Three (10%) patients developed wound infection. One (3.3%) patient developed urethrocutaneous fistula and one (3.3%) patient had chordee. Wound infections were treated conservatively. Twenty eight (93.3%) patients out of 30 had subjective improvement of urine flow after operation. All of these patients had postoperative Qmax >10 ml/sec. Postoperative Retrograde Urethrogram (RGU) of 28(93.3%) patients was free of stricture and 2(6.7%) patients showed stricture who had postoperative Qmax <10 ml/sec. Overall success rate was 93.3% at 3 to 12 months follow up. Unilateral urethral mobilization approach for dorsolateral free graft urethroplasty is feasible for long segment anterior urethral strictures with good short term success.DOI: http://dx.doi.org/10.3329/bmrcb.v37i3.9117 BMRCB 2011; 37(3): 78-82
Dialyzer reuse: a logical practice in hemodialysis
Authors: Kashem Md Abul , Dutta Pradip Kumar , Huda Nurul , Das Saibal , Yunus Emran Bin , Chowdhury Dipti
Published: December 2011

Keywords: hemodialysis; dialyzer reuse; dialyzer efficacy; economical benefitsDOI: http://dx.doi.org/10.3329/jcmcta.v22i1.9105JCMCTA 2011; 22(1): 11-14
Induction of labour versus expectant management in women with premature rupture of membranes between 34 to 37 weeks of gestation
Authors: Ferdous Afroza , Chowdhury Shahanara , Akter Rowshan
Published: December 2011

Keywords: PROM; preterm labour; chorioamnionitisDOI: http://dx.doi.org/10.3329/jcmcta.v22i1.9106 JCMCTA 2011; 22(1): 15-19
Incidence of carcinoma breast in females presenting with breast lumps
Authors: Alam Ashraful Sylvia , Sharmin Farzana , Faruq Tima
Published: December 2011

Keywords: breast lumps; infiltrating duct carcinoma; fibrocystic diseaseDOI: http://dx.doi.org/10.3329/jcmcta.v22i1.9108 JCMCTA 2011; 22(1): 25-27
Tuberculosis - sarcoidosis association: a case report
Authors: Dutta Asok Kumar , Dutta Pradip Kumar , Zahed ASM , Chowdhury Suman , Habib Maruf Bin
Published: December 2011

Keywords: tuberculous sarcoidosis; caseating granuloma; non-caseating granulomaDOI: http://dx.doi.org/10.3329/jcmcta.v22i1.9111 JCMCTA 2011; 22(1): 35-38
Urinary proteomics in diagnosis of kidney diseases
Authors: Dutta Pradip Kumar , Islam Md Nazrul , Dutta Arup
Published: December 2011

Keywords: proteomics; mass spectrometry; biomarkersDOI: http://dx.doi.org/10.3329/jcmcta.v22i1.9114 JCMCTA 2011; 22(1): 47-53
Hysterectomy: recent trends & alternatives: an overview
Authors: Chowdhury Shahanara , Noor Sirajun , Ferdous Afroza
Published: December 2011

Keywords: hysterectomy; laparoscopy; recent trendsDOI: http://dx.doi.org/10.3329/jcmcta.v22i1.9115 JCMCTA 2011; 22(1): 54-60
Comparison of Different Microscopic Methods with Conventional TB Culture
Authors: Rahman Farjana , Munshi Saurab Kishore , Kamal SM Mostofa , Rahman ASM Matiur , Rahman M Majibur , Noor Rashed
Published: December 2011

Tuberculosis is considered as the greatest cause of death worldwide. In the developing countries including Bangladesh, population density, poverty, malnutrition, and highly congested environment may create substantial risk for infection with Mycobacterium tuberculosis. The principal obstacle in the treatment of tuberculosis is the consumption of time and inaccurate diagnosis as well. Therefore, a retrospective study was carried out in order to compare results obtained by both the conventional AFB (Acid Fast Bacilli) microscopy and Lowenstein-Jensen (L-J) culture method for detection of Mycobacterium spp. in clinical samples from different categories of patients. Among one hundred and fifty samples, 83 (55.3%) AFB+ results were found under Bright-Field (BF) microscopy, 78 (52%) AFB+ and 91 (60.7%) AFB+ results were observed under conventional and Light Emitting Diode (LED) fluorescence microscopy. On L-J culture media, 103 (68.7%) AFB+ isolates were found which reveals that the culture could be a gold standard for diagnosis of TB. Significantly, the sensitivity and specificity of LED fluorescence microscopy was higher than those of other microscopic methods compared to culture. The resistance rate of isolates was higher for isoniazid (65%) and rifampicin (63.1%) than streptomycin (53.4%) and ethambutanol (38.8%). The isolates showed resistance to more than one drug. Among one hundred and three cases, total 36 (24.7%) cases reported as MDR-TB (resistant to all first-line drugs) in previously treated patients but it was nil in the new cases. Thus, this study emphasizes the need of Directly Observed Treatment Short Course (DOTS) program for selection of proper anti-tubercular drug therapy towards the patient rather than providing them with empirical therapy and thereby reducing the alarming increase of drug resistance. DOI: http://dx.doi.org/10.3329/sjm.v1i1.9133 Stamford Journal of Microbiology, Vol.1(1), July 2011, p.46-50
A Comparison of Risk Estimates for the Effect of Short-Term Exposure to PM, NO2 and CO on Cardiovascular Hospitalizations and Emergency Department Visits: Effect Size Modeling of Study Findings
Authors: Kirrane Ellen , Svendsgaard David , Ross Mary , Buckley Barbara , Davis Allen , Johns Doug , Kotchmar Dennis , Long Thomas C. , Luben Thomas J. , Smith Genee , Wichers Stanek Lindsay
Published: December 2011

Although particulate matter (PM), nitrogen dioxide (NO2) and carbon monoxide (CO) typically exist as part of a complex air pollution mixture, the evidence linking these pollutants to health effects is evaluated separately in the scientific and policy reviews of the National Ambient Air Quality Standards (NAAQS). The objective of this analysis was to use meta-regression methods to model effect estimates for several individual yet correlated NAAQS pollutants in an effort to identify factors that explain differences in the effect sizes across studies and across pollutants. We expected that our consideration of the evidence for several correlated pollutants in parallel could lead to insights regarding exposure to the pollutant mixture. We focused on studies of hospital admissions for congestive heart failure (CHF) and ischemic heart disease (IHD), which have played an important role in the evaluation of the scientific evidence communicated in the PM, NO2, and CO Integrated Science Assessments (ISAs). Of the studies evaluated, 11 CHF studies and 21 IHD studies met our inclusion requirements. The size of the risk estimates was explained by factors related to the pollution mixture, study methods, and monitoring network characteristics. Our findings suggest that additional analyses focusing on understanding differences in effect sizes across geographic areas with different pollution mixtures and monitor network designs may improve our understanding of the independent and combined effects of correlated pollutants.
Structural Requirements of N-Substituted Spiropiperidine Analogues as Agonists of Nociceptin/Orphanin FQ Receptor
Authors: Bao Pingping , Zhang Xiaole , Ren Hong , Li Yan , Mu Zulin , Zhang Shuwei , Li Guohui , Yang Ling
Published: December 2011

The nociceptin/orphanin FQ (NOP) receptor is involved in a wide range of biological functions, including pain, anxiety, depression and drug abuse. Especially, its agonists have great potential to be developed into anxiolytics. In this work, both the ligand- and receptor-based three-dimensional quantitative structure–activity relationship (3D-QSAR) studies were carried out using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) techniques on 103 N-substituted spiropiperidine analogues as NOP agonists. The resultant optimal ligand-based CoMSIA model exhibited Q2 of 0.501, R2ncv of 0.912 and its predictive ability was validated by using an independent test set of 26 compounds which gave R2pred value of 0.818. In addition, docking analysis and molecular dynamics simulation (MD) were also applied to elucidate the probable binding modes of these agonists. Interpretation of the 3D contour maps, in the context of the topology of the active site of NOP, provided insight into the NOP-agonist interactions. The information obtained from this work can be used to accurately predict the binding affinity of related agonists and also facilitate the future rational design of novel agonists with improved activity.
1,3-Di(4-benzyloxybenzoyl)indole
Authors: Lin Shu-Kun
Published: December 2011

The general part of the experimental section [1] has been presented elsewhere.[...]
Propyl 3-(1,2,3,4-Tetrahydro-1,3,6-trimethyl-2,4-dioxopyrimidin-5-yl)butanoate
Authors: Zhuo Jin-Cong , Wyler Hugo
Published: December 2011

The compound 2 was prepared by the addition of propanol to 1 according to the reported procedure [1].[...]
Synthesis of (4R,5R)-2-Ethoxy-4,5-bis[(1-methoxy-1-methyl)ethyl]-1,3-dioxolane
Authors: Patiny Luc
Published: December 2011

The title compound was prepared from 5 g (89 mmol, 1 eq) of (3R,4R)-2,5-dimethoxy-2,5-dimethyl- 3,4-hexanediol [1], 4.4 ml (3.95 g, 27 mmol, 1.1 eq) of triethyl orthoformate, 0.05 g (0.25 mmol, 0.01 eq) of p-toluenesulfonic acid monohydrate in 35 ml of cyclohexane under inert atmosphere.[...]
Ethyl N-(3-Phenyl-2-propynoyl)carbamate
Authors: Hubmann Dieter , Séquin Urs
Published: December 2011

During the synthesis of a series of carboximides using acyl isocyanates [1], the title compound 3 was synthesised in a model reaction from 3-phenyl-2-propynoyl isocyanate (2) and ethanol. Isocyanate 2 was generated in situ from the corresponding carboxamide (1) with oxalyl chloride [2].[...]
4-(2,4-Dimethoxybenzyliden)-2-butenolide
Authors: Sorotskaya Lyudmila , Kaklyugina Tatyana Ya. , Badovskaya Larisa
Published: December 2011

The general part of the experimental section [1] has been presented elsewhere.[...]
4,5-Dimethoxy-2-nitroacetophenone
Authors: Zavgorodniy Dmitrij , Butin Alexander , Stroganova Tat'yana
Published: December 2011

The general part of the experimental section [1] has been presented elsewhere.[...]
3,5-Bis[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]benzenamine
Authors: Osterod Frank , Kraft Arno
Published: December 2011

The reduction was carried out as described in reference [1] by using a mixture of sulfur (7.10 g, 0.22 mol), Na2S — 9 H2O (240 g, 0.22 mol), water (140 mL) and pyridine (20 mL).[...]
1,3-Bis(pyrrolidin-2-on-1-yl)but-1-ene
Authors: Zhuo Jin-Cong
Published: December 2011

To a solution of 1-vinyl-2-pyrrolidinone (1, 11.1 g, 100 mmol) in CH2Cl2 (100 ml) was added a drop of CF3CO2H at room temperature.
1-Benzimidazolyl-1-benztriazolylmethane
Authors: Viktor Milata , Rudolf Kada
Published: December 2011

Symmetrically substituted bis(azolyl)methanes are often prepared from azoles in dichloromethane under PTC conditions [1] [...]
4,5-Dihydro-3-(4-chlorophenyl)-5-decylisoxazole
Authors: Hathaway Bruce , Mueller Ryan
Published: December 2011

To a solution of 4-chlorobenzaldehyde oxime (0.40g) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of 1-dodecene and 3 drops of triethylamine.
2-Ethoxycarbonyl-3-(2-furyl)-5-hydroxy-5-methylcyclohexanone
Authors: Usova Elena , Lysenko Ludmila , Krapivin Gennady
Published: December 2011

Furylcyclohexanones can be prepared by the reaction of acetoacetic ester (AAE) with b-furyl-a,b-unsaturated ketones [1,2].[...]
4-Furyl-6-hydroxy-6-methyl-1,2,4,5,6,7-hexahydro-3H-indazole-3-one
Authors: Usova Elena , Lysenko Ludmila , Krapivin Gennady
Published: December 2011

It is known that indazoles have varied biological activity [1,2].[...]
4-Amino-1-methylbenzimidazole
Authors: Viktor Milata , Ilavsky Dusan , Salon Josef
Published: December 2011

Heterocyclic amines [1] can be prepared from the corresponding nitro-group containing compounds by catalytic or chemical reduction [2] [...]
1-(6-Amino-9H-purin-9-yl)-3-diazoacetone
Authors: Kovács Lajos
Published: December 2011

Adenine (1, 0.676 g, 5.0 mmol) was suspended in anhydrous DMF (20 mL) and sodium hydride (55-60 % suspension in mineral oil, 0.262 g, 6.0 mmol) was added at room temperature.[...]
Methane-diphosphonic Acid Tetraethyl Ester
Authors: Villemin Didier , Thibault Frédéric
Published: December 2011

Methanediphosphonic acid tetraethyl ester is a useful intermedaite for the synthesis of phosphonoalkenes [1] or diphosphonoalkenes [2].[...]
(6bR*,9aR*)-6-(2-Benzyloxy-1-oxoethyl)-6b,9a-dihydro-5-hydroxy- 4-methoxyfuro[3,2-b]naphtho[2,1-d]furan-8(9H)-one
Authors: Brimble Margaret , Park Josephine
Published: December 2011

A solution of ceric ammonium nitrate (37 mg, 0.067 mmol) in water was added dropwise to a vigorously stirred solution of naphthol 1 (13 mg, 0.036 mmol) [1] in acetonitrile (2.2 ml) at room temperature and stirred for 15 min.[...]
3-[5-(tert-Butyldimethylsilyloxy)-3-(3,5-dinitrobenzoyl)-1-oxo- 2-(phenylmethoxy)hexyl]-4-(phenylmethyl)-2-oxazolidinone
Authors: Brimble Margaret , Park Josephine
Published: December 2011

A mixture of alcohol 1 (104 mg, 0.20 mmol) [1], triethylamine (41 l, 0.30 mmol) and 3,5-dinitrobenzoyl chloride (55 mg, 0.24 mmol) in dichloromethane (2 ml) was stirred for 2 h. at 30ºC.[...]
(4R,2'R,3'R,5'R)-3-[5-(tert-Butyldimethylsilyloxy)-1-oxo-2,3-bis(phenylmethoxy)hexyl]-4-(phenylmethyl)-2-oxazolidinone
Authors: Brimble Margaret , Park Josephine
Published: December 2011

To a suspension of sodium hydride (5.9 mg, 60% in oil, 0.15 mmol) in tetrahydrofuran (0.34 ml) which contained a few drops of N,N-dimethylformamide, under nitrogen at 0°C, was added alcohol 1 (65 mg, 0.11 mmol) [1] in tetrahydrofuran (1.7 ml).[...]
(4R,2'R,3'R,5'R)-3-[3,5-Bis(tert-butyldimethylsilyloxy)-1-oxo-2-(phenylmethoxy)hexyl]-4-(phenylmethyl)-2-oxazolidinone
Authors: Brimble Margaret , Park Josephine
Published: December 2011

To a solution of alcohol 1 (225 mg, 0.43 mmol) [1] in dry N,N-dimethylformamide (0.9 ml) at 0°C under an atmosphere of nitrogen was added imidazole (72 mg, 1.1 mmol) and tert-butyldimethylsilyl chloride (67 mg, 0.45 mmol).
(4R)-1'-Acetyl-2,3-O-isopropylidene-methylspiro [4,6-dideoxy-ß-D-ribo-hexopyranosid-4,5'-imidazolidin]-2',4'-dione
Authors: Steiner Bohumil , Gajdos Jan , Koos Miroslav
Published: December 2011

Acetylation of hydantoins (imidazolidin-2,4-diones) and their 5-substituted derivatives normally occurs more readily in the 1-position [1].[...]
3-Benzyl-4-(N-benzylcarbamoylmethyl)-2-(3-pyridyl)-1,3-oxazolidine
Authors: Tlekhusezh Marina , Makuilov Roman , Badovskaya Larisa
Published: December 2011

The title compound was synthesized by the reaction of N-benzyl-3-benzylamino-4-hydroxybutanamide with 3-pyridinecarboxaldehyde using the procedure described in [1].[...]
Ethyl 2-(n-Butylamino)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate
Authors: Kovács Lajos , Forgó Péter
Published: December 2011

Ethyl 2-cyano-3,3-bis(methylthio)acrylate 1 [1] (3.255 g; 15.0 mmol) was dissolved in anhydrous ethanol (100 mL), n-butylamine (1.100 g; 15.0 mmol) was added and the solution was heated to reflux for 2 h in a flask equipped with a gas outlet to remove the evolving methanethiol (hood).[...]
6-S-Trityl-mercapto-hexan-1-ol
Authors: Kupihár Zoltán , Schmél Zoltán , Kovács Lajos
Published: December 2011

6-S-Trityl-mercapto-hexan-1-ol is an important compound, because its O-b-cyanoethyl-N,N-diisopropyl phosphoramidite derivative is the most widely used building block for the synthesis of 5'-thiol modified oligonucleotides.[...]
Menthyl Phenylsulfonyl Acetate
Authors: Ramdani Mohammed , Elidrissi Abderrahmane
Published: December 2011

Menthyl phenylsulfonyl acetate was prepared from methyl phenylsulfonyl acetate by solid-liquid PTC trans-esterification conditions without a solvent [1].[...]
1-[(2-Acetoxyethoxy)methyl]-3-methyl-5-bromo-6-azauracil
Authors: Radi Smaail , Lazrek Hassan
Published: December 2011

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...]
1-[(2-Acetoxyethoxy)methyl]-3-benzyl-5-bromo-6-azauracil
Authors: Radi Smaail , Lazrek Hassan
Published: December 2011

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...]
[2R*,5S*,6S*]-2-Methyl-1,7-dioxaspiro[5.5]undec-2-en-5-ol
Authors: Brimble Margaret , Johnston Andrew
Published: December 2011

The reaction and the product ratio shown in the scheme was reported [1] [...]
2-Chloro-3-(4-morpholino)-1,4-naphthoquinone
Authors: Bhattacharyya Sukanta
Published: December 2011

The title compound, a novel electron donor-acceptor system [1] was prepared [2] by refluxing a suspension of commercially available 2,3-dichloro-1,4-naphthoquinone in absolute ethanol and morpholine in the presence of anhydrous potassium carbonate.[...]
6-Amino-2-phenylimidazo[4,5-e][1,3]diazepine-4,8(1H, 5H)-dione
Authors: Chen Huan-Ming , Hosmane Ramachandra
Published: December 2011

The starting imidazole diester (1) was prepared by esterification of the corresponding dicarboxylic acid acccording to the literature procedure [1,2].[...]
1,2-Ethylene-bis(p-N2-phenylene-N1,N1-dimethylformamidine)
Authors: Coseri Sergiu , Caraculacu Adrian
Published: December 2011

A mixture of 4.28 mmol (1.1328 g) bibenzil-4,4-di-yl-diisocyanate (1) [1] and 84 mmol (6.14 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring using a magnetically stirring-bar for 12 h, with complete absorption for any carbon dioxide in aqueous potassium hydroxide solution [2].[...]
1,2-Ethylene-bis(o-N2-phenylene-N1,N1-dimethylformamidine)
Authors: Coseri Sergiu , Caraculacu Adrian
Published: December 2011

A mixture of 3.71 mmol (0.98 g) of bibenzil-2,2-di-yl-diisocyanate (1) [1] and 74.16mmol (5.42 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring for 8 h, with complete absorption of any carbon dioxide in aqueous potassium hydroxide solution [2].
Bis[(2-benzylideneimino)phenyl]amine
Authors: Zhao Ke-Qing , Hu Ping , Li Quan , Xu Hong-Bo
Published: December 2011

Imine and amine ligands have been widely used in the field of transition metal catalyzed olefin polymerization [1].[...]
Trimethyl(trifluorovinyl)silane
Authors: Trifu Roxana , Gould George
Published: December 2011

Trimethyl(trifluorovinyl)silane was prepared [1] without characterization details from bromotrifluoroethylene, which is not commercially available.[...]
[3R*,5S*,6S*]-5-Hydroxy-1,7-dioxaspiro[5.5]undec-3-yl 3,5-Dinitrobenzoate
Authors: Brimble Margaret , Johnston Andrew
Published: December 2011

To a solution of [3R*,5S8,6S*]-1,7-dioxaspiro[5.5]undecane-3,5-diol (50 mg, 0.27 mmol) in dichloromethane (5.0 ml), was added triethylamine (56 mg, 0.55 mmol), 4-dimethylaminopyridine (~1 mg), and 3,5-dinitrobenzoyl chloride (64 mg, 0.28 mmol) and the resultant solution allowed to stand at room temperature for 48 h.[...]
1-(4-Nitrophenyl)-1-octyne
Authors: Hathaway Bruce , Blanner Steven
Published: December 2011

Following the procedure of Takahashi, et al (1), to a mixture of 1-iodo-4-nitrobenzene (7.76 mmol, 1.90g) and 1-octyne (9.3 mmol, 1.023g) in diethylamine (40 mL) are added bis[triphenylphosphine]palladium dichloride (0.2mmol, 0.14g) and copper(I) iodide (0.1mmol, 0.01g).[...]
2-(4-Biphenyl-1-yl)-1,3-diazaspiro[4,5]dec-1-en-4-thione
Authors: Sedlak Milos , Hanusek Jirí
Published: December 2011

The title compound was prepared from imidazolinone 1 whose synthesis as well as 1H and 13C NMR spectra were published previously [1].[...]
2-Carbomethoxynor-31-lanosten-2-enol
Authors: Daoubi M. , Benharref A. , Pierrot M.
Published: December 2011

To sodium hydride (0.3g, 12.7 mmole) carefully washed with anhydrous benzene under nitrogen (to eliminate mineral oil from the commercial product) [1], was added (0.8 ml, 8.43 mmole) of dimethylcarbonate (freshly distilled) in dry benzene (20 ml).[...]
bis[(N-Benzyloxycarbonyl)-(2R)-amino-4-methylpentyl]disulfide
Authors: Poudrel Jean-Marc , Karuso Peter
Published: December 2011

Disulfides that mimic the pentapeptide Phe-D-Leu-Gly-D-Leu-Phe can be obtained in high yield from the corresponding thioacetate via the intermediate mercaptan by prolonged standing in alkali [1].[...]
[3R*,5S*,6S*]-1,7-Dioxaspiro[5.5]undecane-3,5-diyl Bis(3,5-dinitrobenzoate)
Authors: Brimble Margaret , Johnston Andrew
Published: December 2011

To a solution of [3R*,5S8,6S*]-1,7-dioxaspiro[5.5]undecane-3,5-diol (50 mg, 0.27 mmol) in dichloromethane (5.0 cm3), was added triethylamine (60 mg, 0.59 mmol), 4-dimethylaminopyridine (~1 mg), 3,5-dinitrobenzoyl chloride (136 mg, 0.59 mmol) and the resultant solution allowed to stand at room temperature for 120 h.[...]
bis[(N-Benzyloxycarbonyl)-(2S)-amino-4-methylpentyl]disulfide
Authors: Poudrel Jean-Marc , Karuso Peter
Published: December 2011

Disulfides that mimic the pentapeptide Phe-Leu-Gly-Leu-Phe can be obtained in high yield from the corresponding thioacetate via the intermediate mercaptan by prolonged standing in alkali [1].[...]
E-(4-Methylbenzylidene)succinic anhydride
Authors: Asiri Abdullah Mohamed
Published: December 2011

The title compound was obtained by dehydration of the corresponding diacid 1 (12.1 g, 55 mmol) by boiling in acetyl chloride (50 ml) for four hours.[...]
8a,9a-Epoxy Nor-31-lanosten-3-one
Authors: Daoubi M. , Benharref A. , Kossareva E. , Pierrot M.
Published: December 2011

To the epoxide 1 (1 g, 2.32 mmol) in acetone (50 ml) [1] was added dropwise at 0°C a solution of CrO3 (0.7 g, 7 mmol) in acetone (20 ml).[...]
8a,9a-Epoxy Nor-31-lanosten-3,4-olactone
Authors: Daoubi M. , Benharref A. , Kossareva E. , Pierrot M.
Published: December 2011

To a mixture of (0.85 g, 4.9 mmol) of metachloroperoxybenzoic acid (mCPBA) [1,2] and (1.63 g, 19.6 mmol) of sodium hydrogenocarbonate (NaHCO3) in 20 ml of dichloromethane was added (1 g, 2.42 mmol) of 1 in 10 ml of CH2Cl2.[...]
8-Dihydro-3-methyl-7-amino-[1,2,4]triazino[3,4-b][1,3,4]thiadiazine
Authors: Heravi Majid , Rajabzadeh Ghadir , Rahimizadeh Mohammad , Bakavoli Mehdi , Ghassemzadeh Mitra
Published: December 2011

8-Dihydro-3-methyl-7-amino-[1,2,4]triazino[3,4-b][1,3,4]thiadiazine 2 was prepared by the cyclocondensation of 4-amino-6-methyl-3-thio-1,2,4-triazin-5-one 1 with chloro-acetonitrile in the presence of triethylamine in refluxing CH3CN.[...]
24,31-Epoxy-24-methyl-elemo-lanost-8,9-ene-3-ol
Authors: El Aouad N. , Benharref A. , Gree R.
Published: December 2011

To a solution of 1g (2.27 mmol) of 1 in 40ml of chloroform at room temperature was added 0.55g (2.27 mmol) of meta-chloroperbenzoic acid (mCPBA).[...]
2-Methyl-5-chloromethyl-8-hydroxyquinoline
Authors: Zhao Ke-Qing , Hu Ping , Zhou Yu-Quan , Xu Hong-Bo
Published: December 2011

Quinoline and its derivatives have been widely used as metal ion chelating agents, metal extracting agents, corrosive inhibitors and they often show biological activity.[...]
Dibutyldichloro(1,10-phenanthroline-N1,N10)tin
Authors: Hu Chun , Tan Rihong , Wang Jianping , Ji Yu , Wang Shengfu
Published: December 2011

Diorganotin dihalide complexes with bidentate nitrogen ligands exhibit some pharmaceutical activities such as antitumour activity, antiviral activity and anti-microbiological activity[1-3], we have synthesized some diorganotin dihalide complexes with bidentate nitrogen ligands, one of which is dibutyldichloro(1,10-phenanthroline-N1,N10)tin.[...]
[4R*,5R*,6S*]-1,7-Dioxaspiro[5.5]undec-4,5-diyl Diacetate
Authors: Brimble Margaret , Johnston Andrew
Published: December 2011

To a solution of [4R*,5R*,6S*]-1,7-dioxaspiro[5.5]undecane-4,5-diol (1) (50 mg, 0.27 mmol) in dichloromethane (10 ml) was added triethylamine (100 mg, 0.99 mmol), acetic anhydride (67 mg, 0.66 mmol) and 4-dimethylaminopyridine (3 mg).[...]
3-Cyano-2-(2,5-dimethoxybenzalamino)-4-5-tetramethylenethiophene
Authors: Asiri Abdullah Mohamed
Published: December 2011

3-Cyano-2-(2,5-dimethoxybenzalamino)-4-5-tetramethylenethiophene was prepared by condensation of 2-amino-3-cyano-4,5-tetramethylenethiophene 1 and 2,5-dimethoxybenzaldehyde 2 [1,2].[...]
(R,S)-N-[(2-Oxocyclohexyl)methyl]-1-butanaminium Chloride
Authors: Stoyanov Edmont , Ivanov Ivo
Published: December 2011

The Mannich bases of cyclohexanone with benzylamine and 3,4-methylenedioxybenzylamine hydrochlorides have been prepared in moderate yields using aqueous formaldehyde solution [1].[...]
(+)-(1R)-N1-{[(1R,1S)-2-Oxocyclohexyl]methyl}-1-phenyl-1-ethanaminium Chloride
Authors: Stoyanov Edmont , Ivanov Ivo
Published: December 2011

The Mannich bases of cyclohexanone with benzylamine and 3,4-methylenedioxybenzylamine hydrochlorides have been prepared in moderate yields using aqueous formaldehyde solution [1].[...]
1-Diazo-2-(2-quinolinyl)-2-ethanone
Authors: Forbes David , Gaston Charles , Lewis Derrick , Morrison Doug , Smith Mary
Published: December 2011

Diazoketone 2 was prepared using 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) as coupling reagent allowing for the efficient transfer of diazomethane to commercially available carboxylic acid 1 [1].[...]
(1S,4R,5R,8R,9S,12R,13S),12-(1S-Hydroxyethyl)-13-(N-benzyl-2-carboxamido Ethyl)-5-(1,5-dimethylhexyl)-1,9-epoxy-4,8,13-trimethyl Tricyclo [7,4,0,0,4,8] Tridecane
Authors: Daoubi M. , Benharref A. , Cortes Diego.
Published: December 2011

A mixture 1 [1] (1 g, 2.25 mmol) and benzylamine [2] as a solvent was refluxed for 3 hours.[...]
2-Formyl nor-31-lanosten-3-enol
Authors: Daoubi M. , Benharref A.
Published: December 2011

To a solution of 1 [1] (1 g, 2.25 mmol) in 50 mL of dry benzene held under nitrogen, was added 0.5 mL of ethyl formate [2] (distilled from phosphorus pentoxide) followed by a solution of (0.45 g, 8.33mmol) of sodium in 35 mL of absolute methyl alcohol.[...]
3-Ethynyl-[1,10]phenanthroline
Authors: Michel Christoph , Habibi Davood , Schmittel Michael
Published: December 2011

The experimental procedure follows a protocol developed by Eaborn [1].[...]
(1S,2S,3R,6R,7R)-Epoxy-himachal-7-ol
Authors: Dakir M. , Lassaba E. , Chekroun A. , Benharref A.
Published: December 2011

To a mixture of lithium aluminium hydride (0,16 g, 4 mmol) in dry ether (50 mL) [1] was added a solution of (10 mL) of epoxide 1 [1,2] (1 g, 4 mmol) in dry ether dropwise at room temperature.[...]
4-Phenyl-2,2'-bis(phenylsulfonyl)butane
Authors: Moghaddam F. Matloubi , Khakshoor O.
Published: December 2011

During our investigation of the chemistry of bis-gemdiphenylsulphinyl and sulfonyls [1], we have prepared the 4-phenyl-2,2'-bis (phenylsulfonyl)butane from the corresponding thioketal by dimethyldioxirane oxidation [2].[...]
Bis[(3-hydroxymethyl-5-methyl pyrazol)-1-yl Thiocarbonyl] Disulfide
Authors: El Idrissi Abderrahman , Tebbji Karim , Radi Smaail
Published: December 2011

This experiment is performed according to literature method [1-4].[...]
9-Methyl-3-phenyl-4H,6H--[1,2,4]triazino[5,4-b][1,3,4]thiadiazin-6-one
Authors: Heravi Majid , Rajabzadeh Ghadir , Rahimizadeh Mohammad , Bakavoli Mehdi , Ghassemzadeh Mitra
Published: December 2011

4-Amino-6-methyl-5-thio-1,2,4-triazin-3-one 1 was reacted with phenacyl bromide in the presence of triethylamine in acetonitrile to give the corresponding 5-phenacylthio derivative 2.[...]
3-Amino-9-methyl-2H,6H--[1,2,4]triazino[5,4-b][1,3,4]thiadiazin-6-one
Authors: Heravi Majid , Rajabzadeh Ghadir , Rahimizadeh Mohammad , Bakavoli Mehdi , Ghassemzadeh Mitra
Published: December 2011

Condensation of 4-amino-6-methyl-5-thio-1,2,4-triazin-3-one 1 with chloro acetonitrile in the presence of triethey amine afforded the corresponding 5-thiocyanomethyl derivative 2.[...]
4,7,7-Trimethyl-bicyclo [2.2.1]heptan-2-ol
Authors: Allal Badia Ait , El Firdoussi Larbi , Allaoud Smail , Karim Abdellah
Published: December 2011

A mixture of Pd(acac)2 (41.26 mg, 0.12 mmol) and CuCl2 (168 mg, 1.25 mmol) [1] in 10 mL of 1,2-dimethoxyethan (DME) was stirred for 30 mn at 80°C under oxygen atmosphere, was added a -pinene (425 mg, 3.12 mmol).[...]
Trans Acetic Acid 5-isopropyl-2-methyl Cyclohex-2-enyl Ester (Trans Carvyl Acetate)
Authors: Ait Allal Badia , El Firdoussi Larbi , Allaoud Smail , Karim Abdellah
Published: December 2011

To a red solution of Li2PdCl4, prepared in situ by mixing LiCl (30.8 mg, 0.72 mmol) and PdCl2 (43 mg, 0.24 mmol) in 20 mL of AcOH stirred at 85°C, was added Cu(OAc)2 (4 g, 20 mmol) and stirred for 30 mn.[...]
3,5-Bis(trimethylsilyl)-4-chloropyridine
Authors: Kay A.J. , Woolhouse A.D.
Published: December 2011

In connection with our studies of the nonlinear optical properties of pyridinylidene compounds we required some pyridine derivatives bearing bulky substituents at the 3- and 5-positions in addition to having an efficient leaving group at the 4-position.[...]
[3,5-Bis(trimethylsilyl)-1-methyl-4(1H)-pyridinylidene]-dicyanomethane
Authors: Kay A.J. , Woolhouse A.D.
Published: December 2011

3,5-Bis(trimethylsilyl)-1-methyl-4-thiophenoxypyridinium iodide reacts with the anion of malononitrile to give the corresponding dicyanomethylidene-1,4-dihydropyridine.[...]
3-Ethoxycarbonyl-1,4-dihydro-2-methylquinoline
Authors: Diadié Camara Hadietou , Khalid Attar , Mohammed Boutayeb , Mohamed Benchidmi , El Mokhtar Essassi
Published: December 2011

Compound 1 [1] (1.23 g, 4.94 mmol ) and 0.1 g of Pd/C (10%) in 50 ml of ethanol are introduced into an hydrogenation reactor.[...]
4-Formylphenyl 4-Ferrocenylbenzoate
Authors: Zhao Ke-Qing , Hu Ping , Xu Hong-Bo
Published: December 2011

Ferrocene unit is comparatively large volume and it needs a longer molecular shape in geometry in to support the liquid crystal property [1].[...]
(4-Formylbenzylidene)-4-ferrocenylaniline
Authors: Hu Ping , Zhao Ke-Qing , Xu Hong-Bo
Published: December 2011

The reaction of 4-ferrocenylaniline with 1,4-benzenedicarboxaldehyde in an equimolar ratio in dilute solution, or with a large excess of the aniline, often gives the diimine product.[...]
Reduction of 5-Nitrosalicylic Acid in Water to Give 5-Amino-salicylic Acid*
Authors: Breviglieri Gabriele , Giacomo Bruno , Sergio Contrini , Cinzia Assanelli , Campanab Eileen , Panunzio Mauro
Published: December 2011

In the course of a general programme aimed to find new protocols for environmentally friend chemistry [1-3] we were looking for a clean, high yielding method of reduction of 5-nitrosalicylic acid (1) to 5-aminosalicylic acid (5-ASA) in industrial scale [4].[...]
2-(2`,3`,5`-Tri-O-acetyl-b-D-ribofuranosyl)-4-(3-nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one
Authors: Haikal Abdelfattah , Zohdi Hussein , El-Neyadi Shaikha
Published: December 2011

To a solution of 4-(3-nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one 1 [1] (0.903 g, 3 mmol) in hexamethyldisilazine (HMDS) (25 ml) was added few crystals of anhydrous ammonium sulfate [2].[...]
2-(b-D-Ribofuranosyl)-4-(3-nitrophenylazo)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one
Authors: Zohdi Hussein , Haikal Abdelfattah
Published: December 2011

The desired compound 2 was obtained by complete deprotection of the acetylated nucleoside 1 [1] using triethylamine [2].[...]
(4-Isopropenyl-cyclohex-1-enyl)acetic Acid Ethylester
Authors: El Houssame Soufiane , El Firdoussi Larbi , Karim Abdellah
Published: December 2011

The carbonylation of allylic componds catalyzed by transition metal complexes under atmospheric pressure of CO is one of the most attractive tools to synthesize the b ,g - unsaturated carbonyl compounds, which are versatile building blocks [1-2].[...]
2-Hydroxy-3-bromo-5-nitrophenylbis(5-methylfur-2-yl)methane
Authors: Gutnov Andrey
Published: December 2011

See also [1, 2].[...]
2-(2'-Cinnamyl-1',3'-oxazolyl)-1,3-dithiolane
Authors: Ahmed Fahim
Published: December 2011

To a mixture of 2-cinnamyl-1,3-oxazole-4-carboxaldehyde [1,2] (2.8 g, 14 mmol) and ethanedithiol (2.3 g, 21 mmol) in methylene chloride (100 ml) was added boron trifluoride etherate (2.8 g, 21 mmol).[...]
6-Methyl-1,3-diphenylpyrazolo[3,4-d]oxazin-4-one
Authors: El Haddad Mohammadine , Akssira Mohamed
Published: December 2011

b-Pyrazolic amino acid [1] (2 mmoles) was dissolved in acetic anhydride [2].[...]
5-Methyl-1,3-diphenylpyrazolo[4,3-d]oxazin-7-one
Authors: El Haddad Mohammadine , Akssira Mohamed
Published: December 2011

In a similar manner to the reported procedure [1,2], b-pyrazolic amino acid [3] (2 mmoles) was dissolved in acetic anhydride.[...]
(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol (Norsanguinine)
Authors: Treu Matthias , Jordis Ulrich
Published: December 2011

Norsanguinine (2) is an alkaloid isolated from the bulbs of L. sanguinea [1] and synthesized as racemate by Kita [2].[...]
tert-Butyl-3-methoxy-5,5-dimethyl-7-hydroxy-heptanoate
Authors: Smith Douglas
Published: December 2011

Hydroboration of tert-butyl-3-methoxy-5,5-dimethyl-6-heptenoate [1] with either BH3ÖTHF or BH3ÖMe2S provided the terminal alcohol title compound, in unoptimized, nonreproducable and disappointingly low 30% yield.[...]
tert-Butyl-3-methoxy-5,5-dimethyl-7-hydroxy-8-trimethylsilyl-9-decenoate
Authors: Smith Douglas
Published: December 2011

The crude aldehyde, tert-butyl-3-methoxy-5,5-dimethyl-7-oxo-heptanoate [1] was treated with pinacol E-1-trimethylsilyl-1-propene-3-boronate [2] in petroleum ether at room temperature to provide a 50% yield of the diastereomeric boronic esters, which were simultaneously cleaved to the alcohols and readily separated by flash chromatography.[...]
tert-Butyl-3-methoxy-5,5-dimethyl-7(E),9-decadienoate
Authors: Smith Douglas
Published: December 2011

The diastereomeric alcohols [1], either separately or as a mixture, were converted under acidic Peterson olefination conditions to the title E-diene.[...]
3-Methoxy-5,5-dimethyl-7(E),9-decadiena
Authors: Smith Douglas
Published: December 2011

Using the Collins oxidation procedure previously described [1], the title aldehyde was prepared from the diene alcohol [2] as a colorless oil in 76% yield.[...]
N-(3,4-Dichlorophenyl)methyl Oxamic Acid
Authors: Lin Shu-Kun
Published: December 2011

A mixture of N-(3,4-dichlorophenyl)methyl oxamic acid ethyl ester [1] (7.609 g, 27.56 mmol), ethanol (400 ml), NaOH (1N, 32 ml) and water (200ml) was stirred at r.t. overnight under N2.[...]
3-Dodecyl-5-methyl-2-oxazolidinone
Authors: Steiner Bohumil , Gajdos Jan , Koos Miroslav
Published: December 2011

2-Oxazolidinones can be synthesized from appropriate beta-amino alcohols by the action of methyl or ethyl trichloroacetate [1].[...]
2-Cyanophenylbis(5-methylfur-2-yl)methane
Authors: Gutnov Andrey
Published: December 2011

The mixture of 2-bromophenylbis(5-methylfur-2-yl)methane [1] (16.55 g, 50 mmol), 5 g CuCN and 5 ml of dry pyridine was heated for 12 hr on the oil bath at 220deg.C, then cooled to 150deg.C and poured onto a mixture of 10 ml ethylenediamine in 100 ml of H2O and 100 ml of benzene.[...]
a,a,a',a'- Tetra(5-methylfur-2-yl)-p-xylene
Authors: Gutnov Andrey
Published: December 2011

See also [1].[...]
1-Methyl-3-nitro-5-methoxycarbonyl Pyrazole
Authors: Baraldi Pier Giovanni , Cacciari Barbara , Romagnoli Romeo , Spalluto Giampiero
Published: December 2011

The nitroester 2 was prepared by the addition of meta-chloro-perbenzoic acid (m-CPBA) to 1 [1] according to the reported procedure [2,3].[...]
(+)-8-Hydroxy-labdan-17-oic Acid
Authors: Martha Ramirez , Nohemi Tellez , Ruben Torrenegra
Published: December 2011

Hanson [1,2] reported a compound with [a]D = -7° and identical IR and NMR spectral data to our compound.[...]
Cycloartan-2b-2-methyl ButanoateIsolated from Genus Espeletia (Asteraceae)
Authors: Nohemi Tellez , Ruben Torrenegra , Julio Pedroyo , Alexander Gray
Published: December 2011

We describe the isolation and characterization of a new cycloartane-type triterpenes, cycloartan- 2b-2-methyl butanoate.[...]
(Z)-1-Bromo-2-methyl-4-phenyl-1-butene
Authors: Stoermer Martin , Pinhey John
Published: December 2011

The general part of the experimental section [1] has been presented elsewhere.[...]
Ethyl 3-Acetoxy-3-methyl-5-phenylpentanoate
Authors: Stoermer Martin , Pinhey John
Published: December 2011

The general part of the experimental section [1] has been presented elsewhere.[...]
Ethyl (Z)-2-Methyl-5-phenyl-2-pentenoate
Authors: Stoermer Martin , Pinhey John
Published: December 2011

The synthetic procedure [1] has been presented elsewhere.[...]