bluuebunny/crossref_metadata_2025 huggingface dataset:
An Efficient Information Services-Centric Framework for Commuter
Authors: Ng Wee Siong , Cheng Justin , Wang XianJun , Viswanathan Sivakumar
Published: January 2012

One of the major objectives of Advanced Traffic Management Systems (ATMS) is to reduce traffic congestion in urban environments by improving the efficiency of utilization of existing transport infrastructures. Many creative and efficient technologies have been developed over the years. Although commuters, especially drivers, take a critical part in containing traffic congestion problems, they are playing a passive role in the traffic-management ecosystem. Considerably, this is due to the information asymmetry between ATMS decision makers and commuters; what is missing is a matching mechanism to create a bridge between information providers and information consumers in the mobile environment. The authors’ solution provides an efficient services-centric framework for delivering pertinent information to commuters. Probe vehicles are used to estimate the real-time traffic flow and disseminate this information effectively to users’ mobile devices. A 2-level indexing scheme is designed to effectively index the grid cells which contain the spatial information and a location-aware mobile application and back-end services are also implemented. Processed information is disseminated to users’ mobile devices through wireless means and presented in a user friendly interface. Experimental results show that this system is scalable and responsive.
Essential Computer Skills for College Students
Authors: Thompson John , Bellanca Mary , Owens Nicole , Lorenzo George
Published: January 2012

Computers have a growing presence in all levels of education and in all kinds of occupations. To be adequately prepared for their chosen professions, undergraduate college students have to be successful in their coursework. To achieve that success, and in consideration of the increasing reliance on using computers in their personal and work lives, students need a certain level of expertise in identified computer applications. Incorporating interviews and surveys, this project researched the computer knowledge needed by incoming undergraduate students in Business Administration and Social Work. The research results found that students need proficiency in Microsoft Office applications, ANGEL learning management system, Internet browser, search engines, and e-mail.
The Impact of IT Resources on the IT Business Value
Authors: Patas Janusch , Bartenschlager Jens , Goeken Matthias
Published: January 2012

Recently, the Resource-based View (RBV) attracts more attention in IT business value research, as it serves as a theoretical framework for the identification of IT resources impacting firm performance. Although numerous empirical studies applying the RBV can be found, systematic research structuring the obtained knowledge is hardly available. Therefore, the authors conduct an evidence-based literature review to structure and consolidate empirical evidence from studies using the RBV as a theoretical foundation. The authors illustrate how different IT resources can be distinguished and classified by considering their operationalization. With the means of a research map, they illustrate the findings and evidence, pointing out contradictory results of how different classes of IT resources affect the IT business value in terms of the competitive advantage. The authors then discuss direct effects of IT resources on the competitive advantage as well as research gaps. Finally, they present implications regarding the RBV in IT business value research.
Technology Related Risks on Virtual Software Development Projects
Authors: Reed April H. , Knight Linda V.
Published: January 2012

Virtual software development projects have a greater reliance on technology than traditional co-located projects because of the need to leverage technology to facilitate or enhance communication among virtual team members. The goal of this research was to determine whether technology-related risks pose a greater risk to virtual projects than to traditional projects. Seven technology-related risks were identified from the literature, individual interviews with IT practitioners, and a focus group. Then 154 practitioners, primarily project managers, participated in an electronic survey that explored the impact of these factors. Results indicate two technology-related risks exhibited a significantly greater impact on virtual IT projects. Project managers need to be aware that (1) traditional project risks can have greater impact on virtual projects, and (2) of the technology-related risk factors, inexperience with the company and its processes and inadequate technical resources have been shown here to pose a greater threat to virtual projects than to traditional projects.
The Information System for Bridge Networks Condition Monitoring and Prediction
Authors: Aboura Khalid , Samali Bijan
Published: January 2012

This paper introduces an information system for estimating lifetime characteristics of elements of bridges and predicting the future conditions of networks of bridges. The Information System for Bridge Networks Condition Monitoring and Prediction was developed for the Roads and Traffic Authority of the state of New South Wales, Australia. The conceptual departure from the standard bridge management systems is the use of a novel stochastic process built out of the gamma process. The statistical model was designed for the estimation of infrastructure lifetime, based on the analysis of more than 15 years of bridge inspection data. The predictive curve provides a coherent mathematical model for conducting target level constrained and funding based maintenance optimization.
Dynamics in Strategic Alliances
Authors: Otto Peter
Published: January 2012

The objective of this paper is to develop a dynamic theory of interorganizational learning and knowledge acquisition in strategic alliances. Strategic alliances are becoming an increasingly important organizational form to gain access to new knowledge and to leverage existing knowledge. By establishing an alliance with one or more partners, an organization will gain valuable learning opportunities to acquire knowledge and to enhance its competitiveness. The degree to which the partners can realize their learning objectives is dependent on their absorptive capacities and the collaborative strategies adopted by the partners. These collaborative strategies may include the trust between alliance partners as well as the willingness to share existing knowledge. In order to gain insights into the dynamics of interorganizational learning and knowledge acquisition, the authors propose a simulation model to test different conditions influencing the outcome of an alliance. The results can improve our understanding of the key factors that influence the acquisition of knowledge in strategic alliances. The paper concludes with a discussion of guidelines to assess and manage the outcome of strategic alliances.
Association Rule Mining Based HotSpot Analysis on SEER Lung Cancer Data
Authors: Agrawal Ankit , Choudhary Alok
Published: January 2012

The authors analyze the lung cancer data available from the SEER program with the aim of identifying hotspots using association rule mining techniques. A subset of 13 patient attributes from the SEER data were recently linked with the survival outcome using prediction models, which is used in this study for segmentation. The goal here is to identify characteristics of patient segments where average survival is significantly higher/lower than average survival across the entire dataset. Automated association rule mining techniques resulted in hundreds of rules, from which many redundant rules were manually removed based on domain knowledge. Further, association rule mining based hotspot analysis was also conducted for conditional survival patient data, i.e., in cases where patients have already survived for a year after diagnosis. The resulting rules conform with existing biomedical knowledge and provide interesting insights into lung cancer survival.
Search for Protein Sequence Homologues that Display Considerable Domain Length Variations
Authors: Mutt Eshita , Mitra Abhijit , Sowdhamini R.
Published: January 2012

Independent folding units which have the capability of carrying out biological functions have been classified as “protein domains”. These minimal structural units lead not only to considerable sequence changes of protein domains of similar folds and functions, but also gives rise to remarkable length variations under evolutionary pressure. Rapid and heuristic sequence search algorithms are generally sensitive and effective in recognizing protein domains that are distantly related within large sequence databases, but are not well-suited to identify remote homologues of varying lengths. An even more challenging aspect is introduced to distinguish reliable hits from a vast number of putative false positives that could have suboptimal sequence similarities. Here, the authors present a data-mining approach that provides stage-specific filters in sequence searches to reliably accumulate remote homologues, which encourages sampling of length variations albeit with a low false positive rate. Realization of such remote homologues with vivid length variations could contribute to better understanding of functional variety within protein domain superfamilies.
Developing Web Prototypes for Mobile-Learning Design Research
Authors: Foley Alan , Luo Heng
Published: January 2012

This paper explores the challenges in developing prototypes for mobile app development and explains how a web-based prototype addresses these challenges and can assist designers in both the design and testing process. The authors explored issues around prototype development by studying a prototype created for iAdvocate, an educational mobile application. Using data from the process of developing and implementing iAdvocate, the authors explore the criteria and requirements regarding the prototype development in mobile-learning design.
IS Security Policy Violations
Authors: Vance Anthony , Siponen Mikko T.
Published: January 2012

Employee violations of IS security policies are reported as a key concern for organizations. Although behavioral research on IS security has received increasing attention from IS scholars, little empirical research has examined this problem. To address this research gap, the authors test a model based on Rational Choice Theory (RCT)—a prominent criminological theory not yet applied in IS—which explains, in terms of a utilitarian calculation, an individual’s decision to commit a violation. Empirical results show that the effects of informal sanctions, moral beliefs, and perceived benefits convincingly explain employee IS security policy violations, while the effect of formal sanctions is insignificant. Based on these findings, the authors discuss several implications for research and practice.
OSS-TMM
Authors: Morasca Sandro , Taibi Davide , Tosi Davide
Published: January 2012

Open Source Software (OSS) products do not usually follow traditional software engineering development paradigms. Specifically, testing activities in OSS development may be quite different from those carried out in Closed Source Software (CSS) development. As testing and verification require a good deal of resources in OSS, it is necessary to have ways to assess and improve OSS testing processes. This paper provides a set of testing guidelines and issues that OSS developers can use to decide which testing techniques make most sense for their OSS products. This paper 1) provides a checklist that helps OSS developers identify the most useful testing techniques according to the main characteristics of their products, and 2) outlines a proposal for a method that helps assess the maturity of OSS testing processes. The method is a proposal of a Maturity Model for testing processes (called OSS-TMM). To show its usefulness, the authors apply the method to seven real-life projects. Specifically, the authors apply the method to BusyBox, Apache Httpd, and Eclipse Test & Performance Tools Platform to show how the checklist supports and guides the testing process of these OSS products.
Chaos-Enhanced Firefly Algorithm with Automatic Parameter Tuning
Authors: Yang Xin-She
Published: January 2012

Many metaheuristic algorithms are nature-inspired, and most are population-based. Particle swarm optimization is a good example as an efficient metaheuristic algorithm. Inspired by PSO, many new algorithms have been developed in recent years. For example, firefly algorithm was inspired by the flashing behaviour of fireflies. In this paper, the author extends the standard firefly algorithm further to introduce chaos-enhanced firefly algorithm with automatic parameter tuning, which results in two more variants of FA. The author first compares the performance of these algorithms, and then uses them to solve a benchmark design problem in engineering. Results obtained by other methods will be compared and analyzed.
Semantics Discovery via Human Computation Games
Authors: Šimko Jakub , Tvarožek Michal , Bieliková Mária
Published: January 2012

The effective acquisition of (semantic) metadata is crucial for many present day applications. Games with a purpose address this issue by transforming computational problems into computer games. The authors present a novel approach to metadata acquisition via Little Search Game (LSG) – a competitive web search game, whose purpose is the creation of a term relationship network. From a player perspective, the goal is to reduce the number of search results returned for a given search term by adding negative search terms to a query. The authors describe specific aspects of the game’s design, including player motivation and anti-cheating issues. The authors have performed a series of experiments with Little Search Game, acquired real-world player input, gathered qualitative feedback from the players, constructed and evaluated term relationship network from the game logs and examined the types of created relationships.
Understanding Users’ Continuance of Facebook
Authors: Hsu Chia-Lin , Wu Cou-Chen
Published: January 2012

The purpose of this study is to develop an integrated model designed to examine users’ continuance of Facebook based on the unified theory of acceptance and use of technology (UTAUT), the expectation disconfirmation model (EDM), and flow theory. Empirical data collected from 482 users who have experience with Facebook are subjected to structural equation modeling based on the proposed research model. Results show that users’ continuance intention of Facebook is determined by social influence, performance expectancy, effort expectancy, flow experience, and satisfaction. Satisfaction is significantly affected by flow experience and disconfirmation. Results also suggest that effort expectancy is positively related to flow experience. Based on the findings, managerial implications are discussed in this paper and directions for future research are also highlighted.
Click if You Want to Speak
Authors: Lamy Marie-Noëlle
Published: January 2012

This paper addresses the lack of formalised methodology for analysing learner interaction data created in conversations on audiographic platforms. First the author shows the importance of conversations in language learning and the need for researchers to understand how users learn from these interactions. Then the author establishes that appropriate methodologies for investigating interaction data collected from online platforms have as yet emerged neither from the field of computer-assisted language learning nor from conversation analysis (CA). Three brief multimodal conversations involving language learners in platform-based tutorials are analysed. The author shows that linguistic means of communication are only one way in which to achieve learning aims and other communication modes are identified. The author concludes that the analysis and interpretation of such exchanges can be improved by a crossdisciplinary approach which consists of augmenting constructs drawn from CA with selected constructs from social semiotics.
The Future of Immersive Instructional Design for the Global Knowledge Economy
Authors: DiBello Lia , Missildine Whit
Published: January 2012

Instructional design has not kept pace with the growth of the globalized knowledge economy. In the area of project management, a volatile global economy requires immersive learning and training exercises targeted to expert learners that have not yet been widely adopted. The authors developed a 16-hour, immersive collective learning experience for mid- to high-level project managers. The exercise was carried out in the Second Life Virtual Worlds platform and aimed to accelerate learning among participants. In addition, the authors tested a number of questions about the capacity of Virtual Worlds to be used for running complex, immersive learning and training. Results indicate that participants experienced high levels of engagement with exercise and, in the second iteration, were able to achieve goals within the exercise. Various technological breakdowns pointed to both the downsides as well as the opportunities for Virtual Worlds to be used for immersive rehearsal engagements.
Design and Evaluation of a Web-Based Tool for Teaching Computer Network Design to Undergraduates
Authors: Sarkar Nurul I. , Petrova Krassie
Published: January 2012

Previous studies have shown that motivating students to learn about local area network (LAN) design can be difficult when presented in the traditional lecture format. To overcome this problem, a Web-based tool (“WebLan-Designer”) was developed as an aid in teaching and learning of LAN design at the introductory level. A WebLan-Designer provides a set of learning resources (tutorials, quizzes, network modeling, network design scenarios, key terms and definitions, and review questions and answers) and assists undergraduate students in learning the basics of both wired and wireless LAN design. The tool is Internet-based and can be accessed at any time so that students can study LAN design at their own pace and convenience. This flexible learning approach contributes positively to distance education and e-learning. The effectiveness of WebLan-Designer is evaluated both formally and informally; positive student and peer feedback indicates that the design and implementation of the tool has been successful and that using WebLan-Designer may have a positive impact on student learning and comprehension.
Endocrine Concerns and Quality of Life in Thalassaemics
Authors: Unver A.
Published: January 2012

I would like to tell you a main message: to fight against this disease is always useful. Imagine you are a little kid and want to play with your friends, you want to run with them play ball with them but you couldn’t. You have to stay at home or sit on the side and watch it is a hard thing to do for a kid. However, the help of your parents, the encouragement and the patience of your doctors, the support of associations are crucial issues to continue the fight. Patients have to remember that continuing their treatments strictly is the main aim to reach in the next future the cure.
Endocrine Investigation and Follow Up in Thalassaemia. Time for Specific Guidelines
Authors: Skordis Nicos
Published: January 2012

Iron overload due to multiple transfusions affects the endocrine glands especially the anterior pituitary, the pancreas, the thyroid and the parathyroids. This leads to a variety of endocrinopathies and growth failure. Delayed puberty, hypogonadism, growth hormone deficiency in adults, hypothyroidism, hypoparathyroidism and diabetes are common and around 20% of patients have more than one endocrinopathy. In this paper suggestions for guidelines concerning diagnosis, investigation and treatment are proposed for the following clinical entities encountered in thalassaemia patients: (i) Growth failure: after the age of 9–10 rears there is a slowing of growth velocity, the pathogenesis of which is multifactorial and anaemia, folate deficiency and hypersplenism are implicated. Desferrioxamine toxicity has been reported as cause of the abnormal upper to lower segment ratio. Growth hormone is given in selected cases. (ii) Delayed puberty and hypogonadism: are the most obvious clinical consequences of iron overload in both sexes. Primary and secondary amenorrhoea are very common in women. Sex steroid replacement therapy is the optimal therapeutic regime which has a great impact on the quality of life of adult thalassaemia patients. (iii) Fertility: Women with TM, who are regularly transfused and are well chelated can now become pregnant either spontaneously or by inducing ovulation. Pregnancy must carefully monitored. (iv) Growth hormone deficiency in adult thalassaemics: This occurs in a high prevalence and since GH in adults is involved in numerous biological functions, especially of the heart, proper assessment of this hormone is needed and consideration of the need for replacement. (v) Hypothyroidism and hypoparathyroidism: these deficiencies are also discussed.
Components of an Effective Large Scale Program for the Prevention of Inherited Hemoglobin Disorders; the Paradigm of Greece
Authors: Loukopoulos D. , Voskaridou E. , Tsalkani M.
Published: January 2012

Large scale prevention programs for Thalassemia major or Sickle cell disease have already been set up in several places with high frequency of the deleterious genes. The Greek health authorities realized the magnitude of the problem and allowed the creation of a National Thalassemia Center in 1972. The incidence of thalassemia in Greece varies from 1–2 per cent up to 15%, the mean being around 8 per cent. With an annual number of births around 100,000, if no prevention measures are taken, the expected yearly number of newborns with thalassemia major in Greece should be of the order of 100–120. To these one should add a few decades of sickle cell patients, homozygotes or compound HbS/β-thalassemia heterozygotes. The total number of patients with thalassemia major now surviving is estimated at 4000 plus another 600–800 patients with sickle cell disease. The National Thalassemia Center Center defined a network of peripheral Thalassemia Units in the major regional hospitals of the country, let them provide free carrier identification to couples requesting the test. When both partners were identified as carriers, they were given preliminary information locally and were referred to the Central Laboratory in Athens for further genetic counselling and, if so decided, prenatal diagnosis. Prenatal diagnosis was provided initially by fetoscopy and fetal blood biosynthesis; this approach was soon replaced by chorionic villi sampling and molecular techniques. The number of prenatal diagnoses carried out yearly over the last decade appears to cover the needs; the number of positive diagnoses is very close to the expected 25%, which also excludes overdiagnosis. The overall evaluation of the the program is reflected in the number of infants who were admitted to the pediatric clinics of the country in need of transfusion over the years the program was functioning. In fact, over the past years this number has steadily decreased to approximately 10 missed diagnoses annually, but has not reached zero as expected, after all this effort. The function of a comprehensive program for the prevention of thalassemia and HbS disease in Greece over the last 25 years has helped enormously in (a) avoiding birth of several hundreds of children with thalassemia major, thus (b) securing the use of the available resources for the optimal care of the patients who are living to-day, and (c) allowing thousands of couples at risk to give birth to healthy children.
Exercise and Sports in Haemoglobin Disorders
Authors: Yazman Dilek
Published: January 2012

Anaemia causes lower oxygen transport to tissues, interfering with normal physical development and may interfere with exercise and sports in thalassemia and Sickle-Cell-Disease (SCD) l. Moreover, in SCD, the abnormal haemoglobin alters the erythrocyte shape and leads to pulmonary parenchymal damage, impaired vascular function and micro vascular complications. However, we now accept that, with regular blood transfusions and efficient oral or parenteral chelation modalities, many patients lead a normal development and life with little or no change from the lifestyle of their unaffected friends, although there are cognitive and emotional factors leading behaviour for participation in the social life and exercise, as studied by many scientists in Italy, United Kingdom, Greece and India.
Detection of Complex Hemoglobinopathies: Recommendations on Screening and DNA Testing
Authors: Baysal E.
Published: January 2012

The following recommendations should be taken into account during the evaluation and elucidation of the complex hemoglobinopathies: (a) in complex hemoglobinopathies performing DNA studies on all family members might be essential; (b) complex gene-gene interactions offer major diagnostic challenges both at the technical and clinical level; (c) hematological & DNA analyses must be run in parallel. Some cases may be straight forward but others may require indepth DNA work-up; (d) co-inheritance of α-thalassemia offers added challenge as it may affect phenotype significantly; (e) sickle cell anemia (SS), co-inherited with a-thal, can be a phenocopy of Sβ0-thal. The HbA2 increase can be mistaken for Sβ-thal. DNA Sequencing is imperative; (f) only a selected number of normal MCV, MCH, borderline HbA2 cases must be referred for DNA analysis. However, in certain cases, following hematological and family evaluation, the β and δ genes may need to be sequenced; (g) DNA Sequencing will increasingly become the method of choice for screening and DNA mutation analysis. However, new methods like MLPA-which analyzes gene dosage- must be used more commonly to rule out deletion mutants to avoid false negative sequencing results; (h) these recommendations should be reviewed every 2–3 years reflecting new methods, new findings and new findings from ethnic groups.
Preimplantation Genetic Diagnosis in the Prevention of the Haemoglobin Disorders
Authors: Kahraman S. , Ekmekçi G.C. , Beyazyürek Ç.
Published: January 2012

Preimplantation Genetic Diagnosis (PGD) is currently an alternative for couples with high risk of pregnancies with genetic anomalies; it offers the possibility of avoiding the need to terminate affected pregnancies, since it allows the selection of unaffected embryos for transfer. PGD for inherited disorders has become extremely accurate (99.5%), and may currently be performed for any single gene disorders in which mutation is identified. PGD has been performed for more than 100 different conditions resulting in the birth of at least 1000 healthy children free of genetic disorder. PGD is presently also used together with preimplantation HLA typing for treatment of affected sibling with genetic and acquired disorders requiring HLA matched stem cell transplantation. This is not only to allow couples to have an unaffected child but also to select a potential donor progeny for stem cell transplantation. In Turkey, thalassemia is the most commonly seen genetic disorder the rate of thalassemia carriers is about 3–4% in Turkey. The majority of our PGD cases are thalassemia carriers. They do not only require thalassemia mutation analysis but also HLA typing for their affected child. In this study PGD results of 236 Turkish couples with or without HLA typing will be presented and discussed. A full diagnosis was achieved in 91.0% of the biopsied samples. In Group I, 17.8% of the analyzed embryos were found to be HLA compatible. HLA compatible and disease free embryos were 12.9% of all diagnosed embryos. In group II, 17.2% of embryos were found to be HLA matched and 71.4% HLA non-matched. The majority of our HLA typing combined with PGD cases were β-Thalassemia carriers (87.9%). The mutations analyzed have high heterogeneity, the most frequent mutation was IVS-I-110 G-A and comprised 46.2% of all mutations. To date, 70 healthy and HLA compatible children have been born. Twenty-five sick children have already been cured with cord blood cell and/or bone marrow transplantation. Twenty-one children are waiting for their newborn siblings to gain sufficient weight and maturity for the donation of stem cells. The successful transplantations have been performed for the following indications: β- Thalassemia (n = 19), Wiskott Aldrich syndrome (n = 2), Glanzmann Disease (n = 1), X-Adrenoleukodystrophy (n=1) and acute myeloid leukemia (n = 1) and Diamond Blackfan anemia (n = 1). This data presents one of the world’s largest experiences on preimplantation HLA typing, and the outcome of stem cell transplantation is the largest number available from one center. Our results indicate HLA typing with or without mutation analysis is a promising and effective therapeutic tool for curation of an affected sibling.
Phenotype-Genotype Correlation in β-Thalassemia
Authors: Galanello R. , Perseu L. , Satta S. , Demartis F.R. , Campus S.
Published: January 2012

The clinical manifestations of β-thalassemia are extremely heterogeneous, ranging from severe transfusion-dependent anemia, to the mild non transfusion dependent thalassemia intermedia and to the asymptomatic carrier state. The remarkable phenotypic variability is primary due to variations in the different globin genes (primary gene modifiers). The main pathophysiological determinant of the severity of β-thalassemia syndromes is the extent of α/non-α globin chain imbalance. Therefore, any factor capable of reducing the globin chain imbalance may have an ameliorating effect on the clinical picture. The most common mechanisms responsible of the amelioration of the phenotype are mild or silent β thalassemia alleles, coinheritance of α thalassemia, or of genetic determinants associated with increased γ globin chain production. Rarely, other complex mechanisms including dominantly inherited β thalassemia, somatic deletion of β globin gene and coinheritance of extra α globin genes with heterozygous β thalassemia have been reported. In addition to the variability of the phenotype resulting from primary gene modifiers, other genetic factors (secondary gene modifiers), mapping outside the β and α globin cluster, may influence the disease complications. Among these factors the ones best so far defined are those affecting bilirubin, iron and bone metabolism. However, the new methods of DNA analysis (i.e., GWAS and related methods) are expect expand the number of genes or gene variants involved in the phenotypic variability and in the response to treatment of β thalassemia.
Transplantation in Low Resource Countries
Authors: Faulkner L. , Yaqub N. , Khalid S. Khalid , Zhara T. , Ansari S. , Farzana T. , Shamsi T.
Published: January 2012

Thalassemia major (TM) is the most common deadly genetic disorder, a major cause of chronic non-infectious morbidity and financial burden in many low and middle-income regions. In these settings few children reach adulthood because proper long-term supportive care is seldom available. Bone marrow transplantation (BMT) is the only available curative modality and it can be very successful and cost-effective for young children with low-risk features and a compatible related donor. However, in countries where TM is most prevalent, there is a dire shortage of BMT centers. The Cure2Children Foundation has supported a feasibility study evaluating safety, efficacy and costs of developing a new BMT center in an underserved lower-middle-income country with relatively untrained professionals within a structured collaboration and knowledge-transfer program. A total of 24 consecutive patients who underwent BMT in Pakistan between September 2008 and August 2010 are included in this prospective analysis, 17 from an established bone marrow transplant center, the National Institute for Blood Diseases in Karachi, Pakistan and the initial 7 BMTs from a start up unit in a government civil hospital, the Pakistan Institute of Medical Sciences Children’s Hospital in Islamabad. Patients were matched for age, nutritional status, growth, disease, disease status and post-BMT follow-up time. All patients had a matched-related sibling donor, were younger than 10 years of age at the time of transplantation, received the same conditioning regimen. All needy families could rely on a support program throughout the 8-month post-transplant period. The Cure2Children Foundation provided professional and financial support as well as a structured web-based data management and cooperation platform. At a median follow up of 19.6 months (range 8.7 to 31.5) actuarial thalassemia-free survival is 85.6% and 85.7% and overall survival 94.1% and 85.7% in the established and start-up center respectively with no statistically significant differences. Other outcome indices like infectious complications, engraftment parameters, transplant-related complications, and post-BMT performance scores also did not differ. The median cost of matched-related transplants in the start-up center, including pre-BMT evaluation, was 11,513 USD (range 7518 to 21,176). Within structured cooperation strategies bone marrow transplantation for thalassemia major can be performed safely, effectively, and affordably even in start-up centers in lower-middleincome countries, like Pakistan, were most thalassemia patients live. This observation may have important implications to increase access to cure for thalassemia worldwide.
On the Numerical Study of Indoor Particle Dispersion and Spatial Distribution
Authors: Jiang Jianbo , Wang Xinlei
Published: January 2012

In this paper, particle dispersion and spatial distribution in a full scale (5.5 m x 2.4 m x 3.7 m) forced ventilated room are investigated using four different multiphase flow models, including passive scalar model, discrete particle phase model, mixture model and Eulerian model. The main differences between these four models lie in how the particles are modeled. A two layer k-∊ turbulence model is used to calculate airflows. Simulated airflow characteristics and particle concentration are compared with corresponding experimental data. The results show that only discrete particle phase model could predict particle concentration distribution close to experimental values and satisfy the published validation criteria (ASTM D5157-97). The reasons for the failure and success of these models in the present case are discussed. Furthermore, the effects of turbulence models of airflows and treatment of boundary conditions on the particle concentration are also investigated.
Release of the Kraken: A Novel Money Multiplier Equation’s Debut in 21st Century Banking
Authors: Hanley Brian P.
Published: January 2012

Historically, the banking multiplier has been in a range of 4 to 100, with 25% to 1% reserve ratios at most layers of the banking system encompassing the majority of its range in recent centuries. Here it is shown that multipliers over 1 000 can occur from a new mechanism in banking. This new multiplier uses a default insurance note to insure an outstanding loan in order to return the value of the insured amount into capital. The economic impact of this invention is calculably greater than the original invention of reserve banking. The consequence of this lending invention is to render the existing money multiplier equations of reserve banking obsolete where it occurs. The equations describing this new multiplier do not converge. Each set of parameters for reserve percentage, nesting depth, etc. creates a unique logarithmic curve rather than approaching a limit. Thus it is necessary to show the behavior of this new equation by numerical methods. Understanding this new multiplier and associated issues is necessary for economic analyses of the Global Financial Crisis.
Multi-wavelength Raman lidar, sunphotometric and aircraft measurements in combination with inversion models for the estimation of the aerosol optical and physico-chemical properties over Athens, Greece
Authors: Mamouri R. E. , Papayannis A. , Amiridis V. , Müller D. , Kokkalis P. , Rapsomanikis S. , Karageorgos E. T. , Tsaknakis G. , Nenes A. , Kazadzis S. , Remoundaki E.
Published: January 2012

Abstract. A novel procedure has been developed to retrieve, simultaneously, the optical, microphysical and chemical properties of tropospheric aerosols with a multi-wavelength Raman lidar system in the troposphere over an urban site (Athens, Greece: 37.9° N, 23.6° E, 200 m a.s.l.) using data obtained during the European Space Agency (ESA) THERMOPOLIS project which took place between 15–31 July 2009 over the Greater Athens Area (GAA). We selected to apply our procedure for a case study of intense aerosol layers occurred on 20–21 July 2009. The National Technical University of Athens (NTUA) EOLE 6-wavelength Raman lidar system has been used to provide the vertical profiles of the optical properties of aerosols (extinction and backscatter coefficients, lidar ratio) and the water vapor mixing ratio. An inversion algorithm was used to derive the mean aerosol microphysical properties (mean effective radius – reff), single-scattering albedo (ω) and mean complex refractive index (m) at selected heights in the 2–3 km height region. We found that reff was 0.3–0.4 μm, ω at 532 nm ranged from 0.63 to 0.88 and m ranged from 1.45 + 0.015i to 1.56 + 0.05i, in good accordance with in situ aircraft measurements. The final data set of the aerosol microphysical properties along with the water vapor and temperature profiles were incorporated into the ISORROPIA model to infer an in situ aerosol composition consistent with the retrieved m and ω values. The retrieved aerosol chemical composition in the 2–3 km height region gave a variable range of sulfate (0–60%) and organic carbon (OC) content (0–50%), although the OC content increased (up to 50%) and the sulfate content dropped (up to 30%) around 3 km height; in connection with the retrieved low ω value (0.63), indicates the presence of absorbing biomass burning smoke mixed with urban haze. Finally, the retrieved aerosol microphysical properties were compared with column-integrated sunphotometer data.
Electron pitch angle distribution during magnetic reconnection diffusion region observations in the Earth's magnetotail
Authors: Borg A. L. , Taylor M. G. G. T. , Eastwood J. P.
Published: January 2012

Abstract. The Earth's magnetosphere provides an excellent laboratory for magnetic reconnection research. In particular, the magnetotail current sheet that is formed between the interface of the similar Northern and Southern Hemispheres of the magnetotail provides a relatively stable symmetric reconnection configuration that can be used to study basic aspects of the reconnection process. Of particular importance is the manner in which electrons are processed by the reconnection. Simulations and satellite data analyses of the ion diffusion region have suggested that the fluxes of electrons in the inflow regions of reconnection are greater in the directions parallel and anti-parallel to the magnetic field (field-aligned) whereas the electron flux in the outflow region is distributed more isotropically. However, this has only been studied experimentally on a case-by-case basis. In this paper, we investigate this claim by analyzing the degree of bulk electron field alignment in the outflow and inflow regions during encounters of the magnetic reconnection ion diffusion region by the Cluster spacecraft in the years 2001–2006. We demonstrate that while the median electron flux in the inflow region is indeed more field aligned than in the outflow region during some ion diffusion region encounters, the variation of the signature across events is so large that it cannot be said to be a general feature of magnetic reconnection in the Earth's magnetotail.
Frequency pattern of turbulent flow and sediment entrainment over ripples using image processing
Authors: Keshavarzi A. , Ball J. , Nabavi H.
Published: January 2012

Abstract. River channel change and bed scourings are source of major environmental problem for fish and aquatic habitat. The bed form such as ripples and dunes is the result of an interaction between turbulent flow structure and sediment particles at the bed. The structure of turbulent flow over ripples is important to understand initiation of sediment entrainment and its transport. The focus of this study is the measurement and analysis of the dominant bursting events and the flow structure over ripples in the bed of a channel. Two types of ripples with sinusoidal and triangular forms were tested in this study. The velocities of flow over the ripples were measured in three dimensions using an Acoustic Doppler Velocimeter with a sampling rate of 50 Hz. These velocities were measured at different points within the flow depth from the bed and at different longitudinal positions along the flume. A CCD camera was used to capture 1500 sequential images from the bed and to monitor sediment movement at different positions along the bed. Application of image processing technique enabled us to compute the number of entrained and deposited particles over the ripples. From a quadrant decomposition of instantaneous velocity fluctuations close to the bed, it was found that bursting events downstream of the second ripple, in Quadrants 1 and 3, were dominant whereas upstream of the ripple, Quadrants 2 and 4 were dominant. More importantly consideration of these results indicates that the normalized occurrence probabilities of sweep events along the channel are in phase with the bed forms whereas those of ejection events are out of phase with the bed form. Therefore entrainment would be expected to occur upstream and deposition occurs downstream of the ripple. These expectations were confirmed by measurement of entrained and deposited sediment particles from the bed. These above information can be used in practical application for rivers where restoration is required.
The occurrence of floods and the role of climate variations from 1880 in Calabria (Southern Italy)
Authors: Polemio M. , Petrucci O.
Published: January 2012

Abstract. In this paper, we present a methodological approach based on a comparative analysis of floods that occurred in a wide region over a long period and the climatic data characterising the same period, focusing on the climate trend. The method simplifies the comparative analysis of several time series by defining some indexes (e.g. the monthly, bi-monthly, and ... m-monthly indexes of precipitation, temperature, wet days and precipitation intensity and the monthly flood number) that can be used to study phenomena such as floods that are characterised by spatial and temporal variability. The analysis was used to investigate the potential effect of climate variation on the damaging floods trend. The approach was tested for the Calabria region (Italy) using historical flood and climatic data from 1880 to 2007. The results showed that the number of floods was correlated with the monthly indexes of precipitation, wet days, and daily precipitation intensity. The following trends were recognised: decreasing precipitation and wet days, almost constant precipitation intensity, increasing temperature, and linearly increasing floods. A second-order polynomial trend analysis showed a slight decrease in floods since the seventies, which might be explained by the favourable climatic conditions during the period and/or the effect of increasing awareness of flood vulnerability.
Comparison of MODIS-derived land surface temperatures with ground surface and air temperature measurements in continuous permafrost terrain
Authors: Hachem S. , Duguay C. R. , Allard M.
Published: January 2012

Abstract. Obtaining high resolution records of surface temperature from satellite sensors is important in the Arctic because meteorological stations are scarce and widely scattered in those vast and remote regions. Surface temperature is the primary climatic factor that governs the existence, spatial distribution and thermal regime of permafrost which is a major component of the terrestrial cryosphere. Land Surface (skin) Temperatures (LST) derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor aboard the Terra and Aqua satellite platforms provide spatial estimates of near-surface temperature values. In this study, LST values from MODIS are compared to ground-based near-surface air (Tair) and ground surface temperature (GST) measurements obtained from 2000 to 2008 at herbaceous and shrub tundra sites located in the continuous permafrost zone of Northern Québec, Nunavik, Canada, and of the North Slope of Alaska, USA. LSTs (temperatures at the surface materials-atmosphere interface) are found to be better correlated with Tair (1–3 m above the ground) than with available GST (3–5 cm below the ground surface). As Tair is most often used by the permafrost community, this study focused on this parameter. LSTs are in stronger agreement with Tair during the snow cover season than in the snow free season. Combining Aqua and Terra LST-Day and LST-Nigh acquisitions into a mean daily value provides a large number of LST observations and a better overall agreement with Tair. Comparison between mean daily LSTs and mean daily Tair, for all sites and all seasons pooled together yields a very high correlation (R = 0.97; mean difference (MD) = 1.8 °C; and standard deviation of MD (SD) = 4.0 °C). The large SD can be explained by the influence of surface heterogeneity within the MODIS 1 km2 grid cells, the presence of undetected clouds and the inherent difference between LST and Tair. Retrieved over several years, MODIS LSTs offer a great potential for monitoring surface temperature changes in high-latitude tundra regions and are a promising source of input data for integration into spatially-distributed permafrost models.
Sacral Hitch Vesical Pexy. A new Ancillary Technique for Ureteroneocystostomy
Authors: Pini Giovannalberto , Leoni Sergio
Published: January 2012

Background

To describe the Sacral Hitch, vesical pexys to sacral promontory, an alternative technique to the Psoas Hitch when this is impossible to perform. We report intraoperative complications, and long-term functional results.

Methods

From 1989 to date we performed 66 ureteroneocystostomies (UNCS) (transbladder technique and Politano-Leadbetter antireflux plasty): 51 with ancillary “Psoas Hitch” (11 Casati-Boari); 15 with “Sacral Hitch” because of the intraoperative finding of deficiency or lack of psoas tendon. Note of technique. Ureter and bladder are dissected as usual. Sacral Hitch: left lateralization of sigmoid and exposition of sacral promontory; longitudinal incision and divarication of peritoneum; smooth dissection of fat tissue, displacement of medium sacral vessels and visualization of neurovascular bundles. Direct fixation of the dome/posterior aspect of bladder to anterior longitudinal ligament above promontory.

Results

Among the patients who underwent the Psoas Hitch technique, 3 (5.4%) showed hypoesthesia, acute pain and impossible flexion of the thigh on hip with EMG positive for femoral (1) and genito-femoral (2) neuropathy. The re-operation in 2 cases solved the symptoms. One case resolved conservatively with corticoids, tricyclic antidepressants (Amitriptyline) and antiepileptics (gabapentin). Mean follow-up was 115 months (8–252); two stenosis of anastomosis.

Sacral Hitch

(15 pts), mean follow-up: 47 months (range 4–110), no stenosis of anastomosis 0%; transfusion rate 0%.

Discussion

The psoas tendon deficiency or its congenital absence (children or women) requires the direct fixation to the muscle, an inadequate and weak target and housing of important sensitive-motor nerves (Genito-femoral, femoral and laterocutaneous). A “Psoas-Syndrome” could be present in 5.1% and a re-operation could be necessary. The sacral promontory represents an affixation target already successfully adopted in other surgery specialties (Gynaecology, Orthopaedic and General Surgery) and gives to UNCS a stiffness plate and an effective bladder cranialization.

Conclusions

Sacral Hitch Vesical Pexys represents an ancillary procedure to UNCS and surgeons should keep it in mind in cases of difficult finding of the psoas muscle tendon.