bluuebunny/crossref_metadata_2025 huggingface dataset:
Search for differentially methylated regions in ancient and modern genomes
Authors: Borodko D. D. , Zhenilo S. V. , Sharko F. S.
Published: December 2023

Currently, active research is focused on investigating the mechanisms that regulate the development of various pathologies and their evolutionary dynamics. Epigenetic mechanisms, such as DNA methylation, play a significant role in evolutionary processes, as their changes have a faster impact on the phenotype compared to mutagenesis. In this study, we attempted to develop an algorithm for identifying differentially methylated regions associated with metabolic syndrome, which have undergone methylation changes in humans during the transition from a hunter­gatherer to a sedentary lifestyle. The application of existing whole­genome bisulfite sequencing methods is limited for ancient samples due to their low quality and fragmentation, and the approach to obtaining DNA methylation profiles differs significantly between ancient hunter­gatherer samples and modern tissues. In this study, we validated DamMet, an algorithm for reconstructing ancient methylomes. Application of DamMet to Neanderthal and Denisovan genomes showed a moderate level of correlation with previously published methylation profiles and demonstrated an underestimation of methylation levels in the reconstructed profiles by an average of 15–20 %. Additionally, we developed a new Python­based algorithm that allows for the comparison of methylomes in ancient and modern samples, despite the absence of methylation profiles in modern bone tissue within the context of obesity. This analysis involves a two­step data processing approach, where the first step involves the identification and  filtration of tissue­specific methylation regions, and the second step focuses on the direct search for differentially methylated regions in specific areas associated with the researcher’s target condition. By applying this algorithm to test data, we identified 38 differentially methylated regions associated with obesity, the majority of which were located in promoter regions. The pipeline demonstrated sufficient efficiency in detecting these regions. These results confirm the feasibility of reconstructing DNA methylation profiles in ancient samples and comparing them with modern methylomes. Furthermore, possibilities for further methodological development and the implementation of a new step for studying differentially methylated positions associated with evolutionary processes are discussed.
'A sociologia...quando ela é bem feita'. Entrevista, 1984-1985
Authors: Elias Norbert , Heilbron Johan
Published: December 2023

Entrevista que Norbert Elias concedeu a Johan Heilbron, publicada em Actes de la recherche en sciences sociales, 2014/5 (n. 205). Tradução de Igor Grill e revisão de José Benevides Queiroz.
Safety Limits for Using Ostrich Olein in Frying Process
Authors: Basuny Amany M
Published: December 2023

Ostrich (Struthio camelus) oil is used as a new source of animal oil. Physical and chemical characteristics for the ostrich oil, profile of fatty acid (%) and unsaponifiable matter (%) were analysis. Ostrich oil was fractionated to two phases (liquid and solid fractions) after fractionated some characteristics of two fractions was measured. Blending process of sunflower oil with liquid fraction (named ostrich olein) showed that oxidative stability, which was evaluated by the Rancimat method at 100°C, was obtained from ostrich oil by dry fractionation. The results indicated that blending process of sunflower oil with liquid fraction (ostrich olein) on effective method to prepare more stable vegetable oils. Ostrich olein was mixed separately with sunflower oil at (75:25, 50:50 and 25:75, v/v). The frying process was conducted at 180°C ± 5°Cfor 16hr/ 4hr per day. Some physical and chemical characteristics of non-fried and fried oil mixture were measured at various heating periods. The results demonstrate that mixing ostrich olein with sunflower oil increased the stability and hence improved the quality of sunflower oil during frying process.
PENGARUH FRAUD HEXAGON TERHADAP FRAUDULENT FINANCIAL STATEMENT
Authors: Maulina Neneng Sherly , Meini Zumratul
Published: December 2023

ABSTRACTFraudulent financial statements are actions that are carried out in a planned manner that harm other parties by presenting incorrect financial information. This research aims to analyze the influence of the fraud hexagon theory, that measured with financial stability, external pressure, financial target, state owned enterprises, ineffective monitoring, and frequent number of CEO’s picture on fraudulent financial statement, empirical study on companies listed on the IDX for the period 2017 – 2021. This research contributes by considering more conditions that affect the possibility of fraud. The number of data samples in this study were 81 manufacturing companies and the total number of observations was 405. This study used Logistic Regression analysis which was processed using SPSS V25. The results of this study indicate that external pressure, state owned enterprises, and frequent number of CEO’s picture has a positive effect on fraudulent financial statement, while financial stability, financial target, and ineffective monitoring does not have effect on fraudulent financial statement. It is hoped that the company will further improve the control of the company, especially in dealing with fraud in financial statements based on the fraud hexagon theory.Keywords: Fraud, Fraud Hexagon, Fraudulent Financial StatementABSTRAKFraudulent financial statement merupakan perbuatan yang dilakukan secara terencana yang merugikan pihak lain dengan cara menyajikan informasi keuangan yang salah. Penelitian ini bertujuan untuk menganalisis pengaruh teori fraud hexagon, dengan menggunakan pengukuran financial stability, external pressure, financial target, state owned enterprises, ineffective monitoring, dan frequent number of CEO’s picture terhadap fraudulent financial statement, studi empiris pada perusahaan yang terdaftar di BEI periode 2017 – 2021. Penelitian ini memberi kontribusi dengan mempertimbangkan lebih banyak kondisi yang mempengaruhi kemungkinan terjadinya kecurangan. Jumlah sampel data pada penelitian ini adalah 81 perusahaan manufaktur dan jumlah total observasi 405. Penelitian ini menggunakan analisis Regresi Logistik yang diolah menggunakan SPSS V25. Hasil penelitian ini menunjukan bahwa kondisi external pressure, state owned enterprises, dan frequent number of CEO’s picture berpengaruh positif terhadap peluang terjadinya kecurangan laporan keuangan. Sedangkan financial stability, financial target, dan ineffective monitoring tidak berpengaruh terhadap fraudulent financial statement. Diharapkan perusahaan untuk lebih meningkatkan pengendalian/kontrol mereka terutama dalam mengatasi kecurangan dalam laporan keuangan berdasarkan teori fraud hexagon.Kata Kunci: Fraud, Fraud Hexagon, Kecurangan Laporan Keuangan
Prevalence and extent of Alveolar dehiscence and fenestration in Class I hyperdivergent subjects with different buccolingual inclinations of maxillary molar teeth
Authors: Mohan Reshma , Jain Ravindra Kumar , Balasubramaniam Arthi
Published: December 2023

Buccolingual position of teeth could affect the prevalence of alveolar bone defects. Presence of alveolar defects may have a deleterious effect on orthodontic treatment. The aim was to assess the prevalence and extent of dehiscence and fenestration in Class I hyperdivergent subjects and correlate it with buccolingual inclinations(BL) of maxillary first molar teeth. Methods: This retrospective study involved 80 CBCTs of class I hyperdivergent subjects divided into two groups - group A (n=33) buccolingual inclination >9º and group B (n=47) buccolingual inclination <9º. Prevalence and extent of alveolar bone dehiscence and fenestrations were measured in CBCTs using OSIRIX Lite software. Descriptive statistics, Mann Whitney U test and Spearman correlation were done for evaluating intergroup differences and correlation with Buccolingual inclination. Results: Overall prevalence of dehiscence and fenestration in maxillary first molars was 60.95% and 5% respectively. In the buccal alveolar bone, prevalence of dehiscence was highest in group A (84.6%) for 16 and in the lingual alveolar bone prevalence of dehiscence was highest in group B (71.4%) for 26 . On intergroup comparison, the extent of lingual alveolar bone dehiscence (26) in group B was significantly higher (p value <0.05) than in group A. No significant correlation between the extent of dehiscence and fenestration with buccolingual inclination of molar teeth was noted. Conclusion: Molar teeth with BL inclinations of more than 9º had higher prevalence of dehiscence on the buccal side and molar teeth with BL inclinations less than 9 degrees had more dehiscence on the lingual side. But no significant correlation of BL inclination with prevalence and extent of dehiscence and fenestration was noted.
Educação em Ciências no Ensino Fundamental
Authors: Zago Marcia Regina R. S. , Calonaci Karen , Krelling Ligia Marcelino
Published: December 2023

Compreender as tendências educacionais da contemporaneidade pode ser ponto de partida para a formação social. Nesta perspectiva, o Projeto Mãos na Massa - Economia Doméstica de costura e customização oferecido pela Secretaria Municipal de Educação de Curitiba (SME), introduz dinâmicas para o Ensino Fundamental II. O objetivo foi analisar o projeto sob o viés da paridade curricular de Ciências. A metodologia destaca a investigação qualitativa, exploratória e descritiva. Nesse fio condutor, foram analisadas as possibilidades educacionais pela abordagem da Educação Ambiental (EA), da Ciência, Tecnologia, Sociedade e Ambiente (CTSA), associadas a Alfabetização Científica e Tecnológica (ACT). Conclui-se que a proposta pode desenvolver a participação crítica nas diversas práticas sociais, quando incrementada pelas diferentes ferramentas de recursos didáticos digitais no processo de ensino-aprendizagem.
Effectiveness of Supply Management Using Kanban System in Hospital Pharmacy Logistics: A Case Study
Authors: Yuniar Cinthya Ratna , Wida Riana  , Ulfa Nur Maa'idah  , Erna Agung Rakhmawati
Published: December 2023

The aims of this research are, first to determine the stock profile of medical consumables before and after the implementation of Kanban system, and second to analysis the effectiveness inventory management of Kanban application. The research method uses descriptive quantitative by comparing the pre-experimental and post-experimental averages. An experiment was conducted to apply the Kanban system to pharmaceutical logistics at a hospital in Ponorogo for two months. Analysis using the FSN method based on TOR, ROP method, Safety Stock method followed by the implementation of the Kanban system. The results obtained are the average pre-Kanban purchase is 6715.7 and post-Kanban is 2232.8. The average ending inventory before Kanban is 8638.6 and after Kanban is 1656.2. The results of the paired t test yield a significant value for purchases of 0.168, which means that there are significant differences in pre-Kanban and post-Kanban purchases. The percentage of effectiveness tested with an N Gain score of 49.362% for purchases and for final stock of 47.655% shows that it is still in the less effective category. The benefit of this research is that in theory it provides an overview of the method for testing the effectiveness of kanban implementation, in practice it provides an overview of Kanban implementation.
VALIDATION OF HEADSPACE SOLID-PHASE MICROEXTRACTION WITH GAS CHROMATOGRAPHY-FLAME IONISATION DETECTOR METHOD FOR ALCOHOL ANALYSIS ON GASTRIC FLUID
Authors: Thaiyibah Nazaratun , Yuwono Mochammad , Yudianto Ahmad
Published: December 2023

Identifying the concentration of alcohol compounds in postmortem analysis of biological fluids can help the investigation, just as postmortem analysis of gastric juices can reveal the concentrations of alcohol consumed. However, an efficient and effective combination of extraction and measurement methods is required when looking at complex postmortem samples. Therefore, a headspace-solid phase microextraction (HS-SPME) method was developed using gas chromatography with a flame ionization detector (GC-FID) to identify postmortem alcohol concentrations. This present study optimizes and validates an effective and efficient method for postmortem alcohol extraction and quantification in gastric fluid. The optimal conditions for HS-SPME extraction using 65μm Polydimethy lsiloxane Divinyl benzene (PDMS/DVB) fiber for analyte isolation were 15 minutes. at 60°C and an exposure time of 1 minute. The validation investigation shows that the suggested approach satisfies the criteria for linearity, precision, accuracy, LOD, and LOQ for postmortem measurement of alcohol in gastric fluid.
WATER ROLE ON DIELS-ALDER REACTION OFPRENYLATED FLAVONOIDFORMATIONIN Boesenbergia pandurata: MECHANISM STUDY
Authors: Rusdipoetra Rahmanto Aryabraga , Kautsar Ul Haq
Published: December 2023

Panduratin A is a prenylated flavonoid derivative from Boesenbergia pandurata with many potential biological activities. The biogenesis of this compound and its derivatives is believed to involve a Diels-Alder reaction between monoterpenoid and chalcone derivatives. This study provides insight into modeling biogenesis through the Diels-Alderreaction for Panduratin A and derivatives biosynthesis. We are using M06-2X/6-31G(d)//PM6 level of theory to explore the potential energy surfaces, asynchronicity degree, and global electron density transfer. Explicit water was applied to mimic physiological conditions. Contrary to the fact that water accelerates this reaction through hydrogen bonding catalysis, we found that water could slow this reaction. These results suggest that this reaction proceeds very slowly under physiological conditions, and enzymes catalyze this reaction.
EFFECT OF MAGNETITE AND CHITOSAN-MAGNETITE ADDITION ON BACTERIAL LEVELS AND NH3-N (FREE-LIVING N2-FIXING BACTERIA CULTURE)
Authors: Umar Ali , Saprudin Deden , Hazra Fahrizal
Published: December 2023

Free-living N2-fixing bacteria are essential in the soil because they provide a source of nitrogen in the form of ammonium needed by plants to be used in building protein blocks. The fixation of free N2 needs to be increased by adding nanomaterials such as magnetite (Fe3O4), which has an active group and can be a source of nitrogenase enzyme cofactor. In this study, increased N2 fixation used N2-fixing bacteria in Burks medium. This increase was determined by measuring NH3 levels using the Phenate method formed after Burks medium was treated with Fe3O4 and chitosan-magnetite (CS-Fe3O4). The study found that the number of bacteria can be well decreased. This research showed that using Fe3O4 and CS-Fe3O4 increased NH3-N levels in cultures of free-living nitrogen-fixing bacteria by 15.40% and 75.54%. For future development, it can be in the form of optimization, the effect of adding the same material to plant secondary metabolites, and the mechanism of bacteria in using the material.
STUDY MOLECULES DOCKING OF ALKALOIDS IN KRATOM ON SEROTONIN TRANSPORTER (SERT), NOREPINEPHRINE TRANSPORTER (NET), AND MONOAMINE OXIDASE (MAO)
Authors: Irawan Dandi , Wijianto Bambang , IH Harianto
Published: December 2023

Kratom (Mitragyna speciosa Korth) is a tropical plant originating from Southeast Asia that predominantly contains alkaloid compounds and can potentially maintain levels of monoamine compounds in the body to treat depression. The study aimed to examine the potential of 8 alkaloid compounds in kratom as antidepressants towards four target proteins: Serotonin Transporter (SERT), Dopamine Transporter (DOPAT), Leucine Transporter (LEUT), and Monoamine Oxidase (MAO) via molecular docking. The Pyrx program is used with exhaustiveness 106 as the protocol, and the grid is adapted to the active site of each receptor. The affinity values ​​of the alkaloid compounds in kratom are mitragynine, 7-hydroxy mitragynine, speciociliatine, paynantheine, speciogynine, corynantheidine, mitraciliatine, and 9-hydroxycorynantheidine, for MAO were -7.1, -6.1, -5.7, -6.7, -5.7, -7.7, -5.7, and -5.7 kcal/ mole. All compounds bind to amino acid residues in the target protein through hydrogen and pi (π) bonds. All the tested alkaloid compounds have the potential to be re-uptake inhibitors SERT, DOPAT, LEUT, and Monoamine Oxidase (MAO).
The Right of The Human to Achieve Justice in the Saudi Judiciary
Authors: Abdulrahman Al-Subhi Abdullah
Published: December 2023

Amid the crises and security, economic, and social challenges facing humanity today, the judiciary is considered a safety valve in the area of crime prevention, achieving security and stability, reassurance, and prosperity. A human's right to achieve and establish justice can only be realized through the existence of judicial institutions, as justice and judiciary are intertwined - there can be no justice without judiciary, and no judiciary without justice. If justice is lost, the judiciary loses its importance, power, and people will no longer trust it or view it to obtain their rights. Therefore, this paper comes in this conference to shed light on the most prominent pillars for achieving justice in the Saudi judiciary as a human right, and the adequacy of these pillars. My study will rely on the descriptive research method for its suitability in analyzing the provisions and regulations governing the Saudi judiciary, and to derive theoretical and practical conclusions in this context.
MAURICE RAVEL’İN BOLERO ADLI ESERİ VE ESERDEKİ TROMBON SOLOSUNUN İNCELENMESİ
Authors: YILDIZ Ahmet
Published: December 2023

20. yüzyılın en önemli bestecilerinden biri olan Maurice Ravel, izlenimci müziğin önde gelen isimlerinden

biri olarak kabul edilmektedir. Besteci yaklaşık kırk yıl süren müzik yaşamı boyunca çeşitli orkestra eserleri,

operalar, piyano konçertoları, oda müziği eserleri ve şarkılar bestelemiştir. Orkestra yapıtları içerisinde en

bilinen eserlerden biri olan Bolero, bestecinin kendi ifadesi ile müziksiz bir orkestra dokusu olarak nitelendirilmiş

ve ilk seslendirildiğinde çok beğenilmesi Ravel’i bile hayrete düşürmüştür. Eserde yer alan trombon solosu

ulusal ve uluslararası orkestra sınavlarında karşılaşılan son derece önemli orkestra sololarından biri olma

niteliği taşımaktadır. Solonun doğru bir biçimde yorumlanabilmesi için icracının teknik ve müzikal bilgi

düzeyinin gelişmiş olması gerekmektedir. Bu çalışmanın amacı, soloda yer alan birtakım teknik ve müzikal

zorlukların çözümüne yönelik Türkçe literatüre katkıda bulunmak ve trombon icracılarına, Ravel’in hayatı

ve Bolero adlı eserinin müzikal yapısı hakkında genel bir bilgi verilmesiyle solonun icrasına yönelik farklı

bir bakış açısı kazandırmaktır. Bu araştırma, Maurice Ravel’in Bolero adlı eseri hakkında literatür taraması

yapılan nitel bir araştırmadır.
TRANSFERRING EXAMPLES OF IRONWORK PRODUCTS IN SAFRANBOLU OLD BAZAAR REGION TO FUTURE GENERATIONS THROUGH A DIGITAL LIBRARY
Authors: KAYA KÖSE Ege , GÖZLÜKAYA Halime
Published: December 2023

This study presents an ongoing research project aimed at contributing to the sustainability of local crafts

through design. By approaching the sustainability of craft production knowledge between the designer and

the craftsman from a unique perspective, the study generates knowledge applicable in industrial production

workshops, particularly in cases where implicit knowledge cannot be easily transferred. Also, the research

seeks answers to questions regarding the transfer of the knowledge of ironworking, which is the last active

guild in Safranbolu, to future generations through designs or areas where designs can contribute. The study

was carried out as a scientific research project in cooperation with Karabuk University and Safranbolu

ironmasters. The research process commenced with background research on Safranbolu ironworks and

continued with the determination of the study area with examples of ironwork. In the application step, three

ironwork samples determined after the craftsman interviews were modelled using a three-dimensional

modelling program. These are examples of door knocker, door ring, door latch. The models were digitally

archived.
DRAKULA COMES TO İSTANBUL: A BRIEF HISTORY OF TURKISH FANTASTIC CINEMA
Authors: FUNDALAR Serkan , YILMAZ Göral Erinç , KASAP Fevzi
Published: December 2023

This article aims to recount a brief history of Turkish fantastic cinema. Although fantastic themes have been

a part of world cinemas almost since the beginning of cinema itself, the first examples of Turkish fantastic

cinema appear much later in the 1950s. Most of the Turkish fantastic movies made between the 1950s and the

1980s are Hollywood and European film adaptations or domestic characters dealing with Western concepts

such as space travel. Nevertheless, these characters and themes undergo significant "nationalization" processes,

where iconic characters of the world cinemas are re-created to fit into a very particular and different cultural

context, becoming a part of the Turkish cinema and the Turkish culture. After exploring the earliest examples

of Turkish fantastic cinema, a brief explanation of the historical fantasy period, the masked heroes period, and

the transition between the space age and galaxy age period is provided in chronological order, along with a

detailed recount of the most exemplary films of each period in an attempt try and reach an understanding of

how these seemingly foreign concepts and characters became an undeniable part of Turkish film culture and

history. The article is concluded with projections about the future of Turkish fantastic cinema.
Low-cost mapping of coastal geomorphology by remote sensing in Angels Cove, Arraial do Cabo, Brazil
Authors: Vargas Ruan , Wasserman Julio Cesar de Faria Alvin , Santos Camila Américo dos , Silva Agenor Cunha da , Dias Fábio Ferreira
Published: December 2023

Bathymetry is a crucial information for understanding coastal geomorphological processes. This study aims to evaluate the applicability of Satellite-Derived Bathymetry (SDB) as a low-cost alternative for coastal geomorphological mapping in Angels Cove. Sentinel-2B images were used for generation of SDBs of coastal environments by two empirical methodologies. Depths were measured in situ by echo sounding for calibration and validation of the models. The models of Angels Beach calibrated with 100% and 50% of the control points were evaluated for cost and time reduction. All SDBs of Angels Beach presented similar geomorphological features and statistics results, with correlations of r ≅ 0.94 both in calibration and validation. When considering half of the control points for model calibration, the total cost for the mapping is estimated to reduce by approximately 50%. A SDB of a submerged sandbar was also mapped with a correlation of r ≅ 0.98 with depth field data. SDB can be used for a quick and low-cost assessment of the geomorphology in Angels Cove. New SDB models can be evaluated from higher spatial resolution satellites to reduce errors.
Blockchain distributed identity management model for cross-border data privacy protection
Authors: Ying Zuobin , Wang Kaichao
Published: December 2023

Cross-border data privacy protection often involves personal privacy data from different regions, where cross-border vehicle identity authentication requires a large amount of sensitive data. The cross-border movement of this sensitive data poses a significant threat to privacy. A distributed identity management blockchain model for cross-border data privacy protection is proposed to avoid the cross-border transmission of sensitive data through identity authentication. The model combines the SM2 and SM9 algorithms and blockchain technology to guarantee the security of stored data while providing a method to avoid sensitive data crossing borders and realizing cross-border identity authentication. The model was originally designed for the Northbound Travel for Macao scenario but can still be applied to other cross-border authentications. The generation speed of a Non-Fungible Token is verified through experiments, and the generation time and efficiency of Non-Fungible Tokens satisfy the actual needs of Internet of Vehicles authentication.
HUBUNGAN TINGKAT KEPARAHAN KARIES TERHADAP KEJADIAN MALOKLUSI PADA ANAK SEKOLAH DASAR
Authors: Izzati Natasya Nurul , Wibowo Diana , Adhani Rosihan , Setyawardhana R. Harry Dharmawan , Azizah Aulia
Published: December 2023

Latar Belakang: Maloklusi masih menjadi permasalahan gigi dan mulut di Indonesia, dengan angka masalah sebesar 80%. Jenis maloklusi yang paling sering ditemui yaitu gigi berjejal. Salah satu faktor penyebab terjadinya maloklusi adalah karies gigi. Masalah karies masih menjadi perhatian di Kalimantan Selatan, dengan prevalensi sebesar 46,9%. Kejadian karies banyak dialami pada periode gigi bercampur, yang rentan terhadap masalah kesehatan gigi dan mulut. Karies yang tidak dirawat akan mempengaruhi kestabilan oklusi normal gigi-geligi sehingga terjadinya maloklusi. Keadaan tersebut dapat menyebabkan suatu keparahan pada gigi permanen jika tidak segera dilakukan perawatan. Tujuan: Menganalisis hubungan tingkat keparahan karies terhadap kejadian maloklusi pada siswa SDN 1 Banua Hanyar di kecamatan Pandawan kabupaten Hulu Sungai Tengah. Metode: Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross-sectional serta analisis data menggunakan uji korelasi Spearman. Jumlah responden adalah sebanyak 39 orang. Hasil: Tingkat keparahan karies berada pada kategori sedang, dengan rata-rata DMF-T sebesar 2,7. Kejadian maloklusi berdasarkan pengukuran Occlusal Index didapatkan kategori maloklusi sedang yang perlu perawatan minor. Hasil uji korelasi Spearman didapatkan nilai signifikansi sebesar 0,831 (>0,05). Kesimpulan: Tidak terdapat hubungan yang signifikan antara keparahan karies terhadap kejadian maloklusi pada siswa SDN 1 Banua Hanyar Kecamatan Pandawan Hulu Sungai Tengah.  Kata kunci: Gigi Bercampur, Karies, Maloklusi, Occlusal Index.
GAMBARAN PROFIL JARINGAN LUNAK SECARA KLINIS DAN FOTO SEFALOMETRI PADA SUKU BANJAR
Authors: Rahimah Aulia , Wibowo Diana , Wardani Ika Kusuma , Azizah Aulia , Tri Putri Deby Kania
Published: December 2023

Latar Belakang: Salah satu penunjang akurat untuk penegakan diagnosa dalam perawatan ortodonti adalah analisis sefalometri. Analisis jaringan lunak pada wajah dapat dilakukan secara klinis dan sefalometri yang dikategorikan menjadi profil wajah cembung, cekung, dan lurus. Salah satu metode analisis sefalometri yang mampu menentukan profil wajah adalah Analisis rickets. Faktor ras dan keanekaragaman kultural sangat berpengaruh terhadap profil wajah seseorang. Tujuan: Menggambarkan profil jaringan lunak secara klinis dan foto sefalometri pada mahasiswa Suku Banjar FKG ULM. Metode: Penelitian deskriptif dengan pendekatan cross sectional. Teknik pengambilan sampel probability sampling menggunakan simple random sampling. Populasi adalah seluruh mahasiswa preklinik yang berasal dari Suku Banjar di Fakultas Kedokteran Gigi Universitas Lambung Mangkurat yang berjumlah 60 orang. Besar sampel minimal dihitung menggunakan rumus Deskriptif kategorik dan didapatkan hasil 39 sampel. Hasil: Analisis statistik deksriptif dari Analisis Rickett menunjukkan rerata jarak bibir atas terhadap garis estetik (Ls-E) adalah 0,34 mm dengan standar deviasi 0,25. Rerata jarak bibir bawah terhadap garis estetik (Li-E) adalah 1,66 mm dengan standar deviasi 2,63. Kesimpulan:  penelitian ini adalah secara klinik dan sefalometri menunjukkan mayoritas responden memiliki profil wajah cembung. Kata Kunci: Analisis Rickett, Profil jaringan lunak, Sefalometri, Suku Banjar.
HUBUNGAN TEMPOROMANDIBULAR DISORDERS TERHADAP ORAL HEALTH RELATED QUALITY OF LIFE
Authors: Hasanah Maulida , Arifin Rahmad , Taufiqurrahman Irham , Sari Galuh Dwinta , Sitepu Alexander
Published: December 2023

Latar Belakang: Temporomandibular disorders (TMD) merupakan gangguan pada sendi temporomandibula (STM) ditandai rasa sakit pada otot pengunyahan dan STM; bunyi ‘klik’ pada STM; dan adanya defleksi, deviasi serta keterbatasan membuka mulut. TMD banyak dijumpai pada usia dewasa dengan rentang 20-40 tahun termasuk pada mahasiswa.  Gejala yang disebabkan TMD dapat berdampak negatif pada kualitas hidup dan kualitas hidup terkait kesehatan rongga mulut. Oral health related quality of life (OHRQoL) merupakan konstruksi multidimensi yang mencerminkan kesehatan mulut seseorang; fisik, psikologis dan kesejahteraan sosial; harapan dan kepuasan perawatan; dan harga diri. Tujuan: Penelitian ini dilakukan untuk mengetahui hubungan TMD terhadap OHRQoL pada mahasiswa preklinik FKG ULM. Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Penelitian ini dilakukan pada 37 mahasiswa FKG ULM Angkatan 2019-2022 yang berusia 18 tahun ke atas dengan teknik pengambilan sampel stratified random sampling dengan kriteria inklusi dan kriteria eksklusi. Pemeriksaan TMD menggunakan metode diagnosis RDC/TMD sedangkan pemeriksaan OHRQoL menggunakan kuesioner OHIP-14. Data hasil penelitian terkait TMD dan OHRQoL dianalisis dengan uji spearman. Hasil: Hasil penelitian menunjukkan bahwa TMD dialami oleh 51,4% responden dengan gejala yang paling banyak dialami adalah nyeri miofasial (57,9%) dengan tingkat OHRQoL yang  terbanyak adalah baik (81%). Hasil uji korelatif spearman menunjukkan bahwa terdapat hubungan yang bermakna antara TMD terhadap OHRQoL pada mahasiswa preklinik Fakultas Kedokteran Gigi Universitas Lambung Mangkurat (ρ < 0,05). Kesimpulan: Peningkatan gejala TMD meningkatkan keparahan OHRQoL pada mahasiswa preklinik Fakultas Kedokteran Gigi Universitas Lambung Mangkurat Kata Kunci: nyeri miofasial, oral health related quality of life (OHRQoL), temporomandibular disorders (TMD)
DEVELOPING THE VALUES OF RELIGION IN PRAYER PRACTICE USING TALKING STICK, DEMOSTRATION SIMULATION, AND DRAWING
Authors: Amalia Rizka , Metroyadi Metroyadi
Published: December 2023

The research is motivated by low religious abilities, such as children being less able to express opinions in continuing some prayer movements. This is due to the lack of innovative and interesting learning media to be displayed, the lack of innovation in learning models and methods used, the lack of stimulus given by teachers to children in learning activities, and children being less able to express ideas in continuing some of the prayer movements they have heard. The approach used is a qualitative approach to the type of research, namely classroom action research, which is carried out in two cycles. This research was carried out at Tri Kesuma Pelaihari Kindergarten on group B children, totaling 10 children, consisting of 5 boys and 5 girls. Based on the research results, it can be concluded that using the talking stick model, demonstration method, and drawing media can develop religious abilities in Group B children at Tri Kesuma Kindergarten. It is recommended that the results of this research be used as a reference and consideration in continuing some of the prayer movements that have been carried out.
THE AVAILABILITY OF FINANCIAL SOURCES TO SMALL AND MEDIUM-SIZED ENTERPRISES FROM NON-BANKING INSTITUTIONS IN THE REPUBLIC OF NORTH MACEDONIA
Authors: Blaževa Slavica
Published: December 2023

This paper examines the challenges and perspectives of SMEs in North Macedonia. The study was conducted through a survey for small and medium-sized enterprises in the country, which revealed significant challenges in access to finance, skilled labor, high taxes, administrative burdens, and limited market access. These challenges hinder the growth and development of SMEs, thereby affecting their contribution to the country's economy. Despite the challenges, small and medium-sized enterprises in North Macedonia represent a significant potential for growth and development, which is seen in their contribution to GDP and the country's employment. To address the challenges faced by SMEs, the government and other stakeholders must prioritize measures that reduce the tax burden on SMEs, simplify administrative procedures, provide export subsidies, invest in transport infrastructure, and explore alternative financing options. Investing in education and training programs tailored to the needs of SMEs will help address the skills gap and increase productivity. The study recommends that the government use opportunities such as the country's strategic location to attract foreign investment, promote trade and create favorable conditions for small and medium enterprises. Small and medium-sized enterprises in North Macedonia face significant challenges, but they represent significant potential for growth and development.
Dynamique spontanée de régénération des peuplements du Nord-Est de la France au cours des 20 ans suivant la tempête de 1999
Authors: Dietz Lucie , Laurent Lisa , Lacombe Eric , Gégout Jean-Claude , Dupouey Jean-Luc , Collet Catherine
Published: December 2023

Suite au passage de la tempête Lothar en 1999, deux observatoires ont été mis en place dans le Nord-Est de la France pour caractériser la dynamique spontanée de recolonisation forestière et aider les gestionnaires dans leur choix d’itinéraire sylvicole. Nous présentons ici l’évolution de la composition dendrologique, de la densité et des diamètres des tiges sur 20 ans, en fonction de la taille de la trouée, de la composition du peuplement pré-tempête et de l’acidité du sol. La régénération naturelle ligneuse dans les trouées post-tempête est satisfaisante en densité et en diversité en essences 20 ans après la tempête, 87 % des sites ayant plus de 2 500 tiges/ha et la strate supérieure à 2 m comptant 4,4 espèces en moyenne sur 314 m2. Les situations présentant une faible densité de tiges ont pu être identifiées trois ans après la tempête : ce sont d’anciens peuplements résineux, sur sol acide où une végétation concurrente s’est développée.Messages clés• Des observatoires permettent de caractériser la régénération (post tempête 1999).• Vingt ans après, la diversité des essences est satisfaisante sauf sur sol acide après d’anciens peuplements résineux.
Enhancing Sentence Representation with Syntactically Structural Transformer
Authors: Elizabeth Petrenko , Patel Rodolfo , Jose Fomuso
Published: December 2023

The evolution of sentence representation learning, especially with parse tree encoders, has shown remarkable progress. Traditional approaches predominantly rely on recursive encoding of tree structures, which impedes parallel processing capabilities. Additionally, these methods often overlook the significance of dependency tree arc labels. To overcome these limitations, we introduce the Syntax-Enhanced Transformer (SET), incorporating a novel dual-attention mechanism that integrates relation-focused attention alongside traditional self-attention. This design effectively encodes both dependency and spatial positional relationships within sentence dependency trees. Our approach innovatively incorporates syntactic information into the Transformer framework without compromising its inherent parallelizability. The SET demonstrates superior or comparable performance to contemporary methods across various sentence representation tasks, significantly enhancing computational efficiency.
Algorithm-Specific Optimizations for On-Board Real-Time Backprojection on FPGA
Authors: Cruz Helena , Flores Paulo , Véstias Mário , Monteiro José , Neto Horácio , Duarte Rui Policarpo
Published: December 2023

This paper details a design optimization on a hardware accelerator for an on-board real-time SAR imaging system using the Backprojection algorithm, focusing on algorithm-specific approximations intended to reduce the overhead introduced by intensive functions such as the square root, sine, and cosine functions. The main novelty of this work is that new approximations were investigated so that the final image retains high quality regardless of the error in the approximation function. This paper revisits existing approximation methods, such as linear interpolation, polynomial approximation using the Vandermonde matrix, and Chebyshev polynomials, and compares their performance on the algorithm. Results demonstrate that it is possible to maintain the image quality with an SSIM above 0.99 with less 93% LUTs for the square root and less 88% LUTs for the sine and cosine functions using polynomial approximation with the Vandermonde matrix when compared to the HLS baseline functions.
Genetic Transformation of Potato Using the Non-selection Approach
Authors: Miroshnichenko Dmitry , Okuneva Anna , Klementyeva Anna , Sidorova Tatiana , Timerbaev Vadim , Pushin Alexander S. , Dolgov Sergey V.
Published: December 2023

The genetic engineering of plants often relies on the use of antibiotic or herbicide resistance genes for initial selection of primary transgenic events. Nevertheless, the commercial release of genetically modified crops containing any marker gene encounters several challenges stemming from the lack of consumer acceptance. Development of strategies enabled the generation of marker-free transgenic plants is a possible alternative to deal with public concerns over the safety of biotech crops. Leveraging the high in vitro regeneration and transformation capabilities of potato, this study examined the factors associated with the development of transgenic plants without presence of selective substances in medium. To compare the antibiotic-assisted with the antibiotic-free transformation, nodal explants from five highly regenerative potato cultivars were inoculated with the Agrobacterium strain AGL0 carrying the pBIN-mGFP5-ER (35SGFP/nosNPTII) plasmid. The efficiency of transient expression and the formation of chimeric and completely transgenic shoots were assessed through vital GFP observations. Under non selective conditions, the regeneration efficiency of stable non-chimeric transgenic shoots varied from 0.9 (‘Chicago’) to 2.7% (#12-36-42). In order to streamline transformation protocol, a specific timeline for collecting transgenic plantlets was established for each analyzed cultivar. This timeline strategy was implemented to generate transgenic potato plants, which demonstrated the suppression of homologous SteIF4Es family genes as a result of the successful introduction of the marker-free hpRNAi construct.
THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating Fak-Beclin 1 Pathway
Authors: Xu Zhen , Lu Jiayi , Gao Song , Rui Yan-Ning
Published: December 2023

Focal adhesions (FAs) play a crucial role in cell spreading and adhesion, and their autophagic degradation is an emerging area of interest. Our study investigates the role of Thrombospondin Type 1 Domain-Containing Protein 1 (THSD1) in regulating autophagy and FA stability in brain endothelial cells, shedding light on its potential implications for cerebrovascular diseases. Our research reveals a physical interaction between THSD1 and FAs. Depletion of THSD1 significantly reduces FA numbers, impairing cell spreading and adhesion, in an autophagy-dependent manner. Intriguingly, THSD1-mediated autophagy activation operates independently of changes in mTOR and AMPK activation, implying that THSD1 primarily governs FA dynamics rather than serving as a global regulator of nutrient and energy status. Interestingly, THSD1 negatively regulates Beclin 1, a central autophagy regulator, at FAs through interactions with focal adhesion kinase (FAK). The loss of THSD1 diminishes FAK activity, consequently relieving its inhibitory phosphorylation on Beclin 1. This, in turn, promotes the complex formation between Beclin 1 and ATG14, a critical event for the activation of the autophagy cascade. In summary, our findings identify THSD1 as a novel regulator of autophagy that degrades FAs in brain endothelial cells. This underscores the distinctive nature of THSD1-mediated, cargo-directed autophagy and its potential relevance to vascular diseases due to the loss of endothelial FAs. Investigating the underlying mechanisms of THSD1-mediated pathways holds promise for discovering novel therapeutic targets in vascular diseases.
New Gall-Forming Insect Model, Smicronyx madaranus: Critical Stages for Gall Formation, Phylogeny, and Effectiveness of Gene Functional Analysis
Authors: Ushima Ryo , Sugimoto Ryoma , Sano Yota , Ogi Hinako , Ino Ryuichiro , Hayakawa Hiroshi , Shimada Keisuke , Tsuchida Tsutomu
Published: December 2023

The molecular mechanisms underlying insect gall formation remain unclear. A major reason for the inability to identify the responsible genes is that most insect galls are produced on woody plants and therefore cannot be experimentally validated in the laboratory. To overcome these problems, we established a new galling insect model, Smicronyx madaranus. Our manipulation experiments using nail polish sealing and insecticide treatment revealed an age-dependent change in gall formation during S. madaranus; adult females and larvae are responsible for gall induction and enlargement, respectively. Furthermore, it has been suggested that substances released during oviposition and larval feeding are involved in each process. Phylogenetic analysis showed that most gall-forming weevils, including S. madaranus, belong to a single lineage, suggesting that gall-forming traits evolved in a specific lineage within Smicronyx. The efficacy of RNA interference (RNAi) in S. madaranus was confirmed by targeting multicopper oxidase 2 gene. It is expected that the mechanisms of gall formation will be elucidated by a comprehensive functional analysis of candidate genes using RNAi and the S.madaranus galling system in the near future.
Screening for viruses in indigenous Greek black pigs
Authors: Jhelum Hina , Papatsiros Vasileios , Papakonstantinou Georgios , Krabben Ludwig , Kaufer Benedikt , Denner Joachim
Published: December 2023

The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening for potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient. To validate these methods, genetically modified pigs generated for xenotransplantation, numerous minipig and other pig breeds have been tested, thereby increasing our knowledge concerning the pig virome and the distribution of pig viruses. Of particular importance are the porcine cytomegalovirus, a porcine roseolovirus (PCMV/PRV) and the hepatitis E virus genotype 3 (HEV3). PCMV/PRV has been shown to reduce the survival time of pig transplants in non-human primates and was also transmitted in the first pig heart transplantation to a human patient. Here, we determined the sensitivities of our methods to detect PCMV/PRV, HEV3, porcine lymphotropic herpesvirus - 1 (PLHV-1), PLHV-2, PLHV-3, porcine circovirus 2 (PCV2), PCV3, PCV4 and porcine parvovirus 1 (PPV1) efficiently and used the methods to screen indigenous Greek black pigs. Since porcine endogenous retroviruses (PERVs) of type A and B are integrated in the genome of all pigs, but PERV-C is not, the animals were screened for PERV-C and PERV-A/C. Our detection methods were sensitive and detected PCMV/PRV, PLHV-1, PLHV-1, PLHV-3, PVC3 and PERV-C in most animals. PPV1, HEV3, PCV4 and PERV-A/C were not detected. These data are of great interest since the animals are healthy and very resistant to diseases.
Evaluating Recalibrating AI Models for Breast Cancer Diagnosis in a New Context: Insights from Transfer Learning, Image Enhancement and High Quality Training Data Integration
Authors: Jiang Zhengqiang , Gandomkar Ziba , Trieu Phuong Dung , Taba Seyedamir Tavakoli , Barron Melissa L. , Obeidy Peyman , Lewis Sarah J.
Published: December 2023

This paper investigates the adaptability of four state-of-the-art Artificial Intelligence (AI) models to the Australian mammographic context through transfer learning, explores the impact of image enhancement on model performance and analyses the relationship between AI outputs and histopathological features for clinical relevance and accuracy assessment. A total of 1712 screening mammograms (n=856 cancer cases and n=856 matched normal cases) were used in this study. The 856 cases with cancer lesions were annotated by two expert radiologists and the level of concordance between their annotations was used to establish image subsets. The area under the receiver operating characteristic curve (AUC) was used to evaluate the performance of Globally aware Multiple Instance Classifier (GMIC), Global-Local Activation Maps (GLAM), I&H and End2End AI models, both in the pre-trained and transfer learning modes, with and without applying the Contrast Limited Adaptive Histogram Equalization (CLAHE) algorithm. The four AI models with and without transfer learning in the high-concordance subset outperformed those in the entire dataset. Applying the CLAHE algorithm to mammograms improved the performance of the AI models. In the high-concordance subset with transfer learning and CLAHE algorithm applied, the AUC of the GMIC model was highest (0.912), followed by GLAM model (0.909), I&H (0.893) and End2End (0.875). There were significant differences (P<0.05) in the performances of the four AI models between high-concordance subset and entire dataset. The AI models demonstrated significant differences in malignancy probability concerning different tumour size categories in mammograms. The performance of AI models was affected by several factors such as concordance classification, image enhancement and transfer learning. Mammograms with strong concordance of radiologists’ annotations, applying image enhancement and transfer learning could enhance the accuracy of AI models.
Deeper Flow Behavior Explanation of Temperature Effects on the Fluid Dynamic inside a Tundish
Authors: Gutiérrez Enif , Garcia-Hernandez Saul , Morales R.D. , Barreto Jose de Jesús
Published: December 2023

The continuous casting tundish is non-isothermal due to heat losses and temperature variation from the inlet stream generating relevant convection forces. This condition is commonly avoided through qualitative fluid dynamic analysis only. This work searches to establish the conditions for which non-isothermal simulations are mandatory or for which isothermal simulations are enough to accurately describe the fluid dynamics inside the tundish by quantifying the buoyant and inertial forces. The mathematical model, simulated by CFD software, considers the Navier-Stokes equations, the realizable k- model for solving the turbulence, and the Lagrangian discrete face to track the inclusion trajectories. The results show that temperature does not significantly impact the volume fraction percentages or the mean residence time results, nevertheless, bigger velocity magnitudes under non-isothermal conditions than in isothermal conditions and noticeable changes in the fluid dynamics between isothermal and non-isothermal cases in all the zones where buoyancy force dominates over inertial forces were observed. Because of the results, it is concluded that isothermal simulations can accurately describe the flow behavior in tundishes when the flow control devices control the fluid dynamic, but the simulation without control devices or with a weak fluid dynamic dependence on the control devices requires non-isothermal simulations.