bluuebunny/crossref_metadata_2025 huggingface dataset:
Çağdaş Türk Çocuk Edebiyatı Eserlerinde Okuma Kültürü
Authors: Aksoy Süleyman , Arıcı Ali Fuat
Published: February 2025

Bu araştırmanın genel amacı, çağdaş Türk çocuk edebiyatı eserlerinde yer alan okuma kültürü unsurlarının sunuluş biçimlerini incelemektir. Bu araştırma, nitel bir araştırma modeli olan durum çalışmasıdır. Araştırmanın inceleme nesnelerini; ölçüt örnekleme yöntemiyle belirlenmiş olan, okuma kültürü temasında yazılmış 15 çağdaş Türk çocuk edebiyatı eseri oluşturmaktadır. Belirlenen kitaplar doküman analiziyle incelenmiştir. İncelenen kitaplarda tespit edilen okuma kültürü unsurlarına ait veriler sınıflandırılmış ve içerik analizi tekniğiyle yorumlanmıştır.
Araştırma sonucunda incelenen eserlerde okuma kültürüne ait olumlu ve olumsuz sunuluş biçimleri tespit edilmiştir. Olumlu sunuluş biçimlerinin çoğunlukta olduğu belirlenmiştir. İncelenen eserler; okuma eylemine, okura, kitaba, kitaplığa ve kütüphaneye yani bir bütün olarak okuma kültürüne karşı okurda olumlu algılar oluşturacak niteliği taşımaktadır. Bu sunuluş biçimlerinde okuma kültürü unsurlarının önemi ve insan hayatındaki konumu yansıtılmıştır. Kitaplık ve kütüphaneye ilişkin sunuluş biçimleri, olumlu iletileriyle okuma kültürünü desteklemesine karşın eserlerde yeterli düzeyde işlenmemiştir. İncelenen eserler, okuma kültürünün gelişimine katkıda bulunmaktadır. Bu eserlerden okuma kültürü edindirme süreçlerinde nitelikli uyaranlar olarak yararlanılabilir. Okuma kültürü temalı Türk çocuk edebiyatı eserlerinin Türk toplumundaki mevcut ve ideal okuma kültürünü yansıttığı, okuma kültürünün gelişiminde bir uyaran olabileceği hesaba katılarak bu doğrultuda nitelikli eserlerin üretilmesi ve bu eserlerin çocuklarla buluşturulması önerilmektedir.
State Regulation of Women's Employment and Occupational Segregation in the Russian Labour Sphere – 100 Years of History (Part 3. 1992-2024)
Authors: Baskakova Marina
Published: February 2025

This paper analyzes changes in the regulation of women’s employment conditions and regimes, as well as the dynamics of gender-based industrial segregation, based on a comprehensive review of policy documents and legislative acts. The first part of the article focuses on the early Soviet period and the Great Patriotic War (1917–1945), when the principle of equality between women and men emphasized the liberation of women from domestic duties through their full participation in the workforce. This was accompanied by efforts to integrate women into industries where their labor had previously been underutilized or excluded, alongside measures to restrict women’s employment in hazardous conditions. During this period, gender-based industrial segregation decreased significantly. The second part examines the post-war Soviet era (1945–1991). A declining birth rate, attributed to the “double burden” of work and family responsibilities borne by women, prompted the state to rethink its approach to gender equality in the workplace. Initially, the focus on maximizing women’s employment was supplemented by efforts to place women in relatively light yet well-paid jobs. Later, policies aimed to create “favorable conditions for women to balance professional and family responsibilities” and eventually called for women to “return to the family.” This period saw the entrenchment of stereotypes depicting women as workers encumbered by family duties, an increase in workplace discrimination, and the emergence of an upward trend in gender-based industrial segregation. This was characterized by the concentration of women in non-manufacturing sectors and men in material production. The third part (1992–2024) explores the post-Soviet history of state regulation of women’s employment. This era began with the legislative establishment of equality not only in rights but also in opportunities for men and women, as well as equal parental responsibilities in child-rearing. However, the focus gradually shifted back toward protectionist policies for women, including the revival of practices regulating the professional composition of employed women. According to Rosstat data, despite the adoption of gender-neutral labor legislation, modern Russian society—steeped in traditional gender roles and emphasizing women’s role as mothers—has seen an increase in the polarization of gender distributions across traditionally “male” and “female” industries.
Dynamic processes during separation of a tank from the bottom as a result of a fire
Authors: Nesukh Mykhailo , Subota Andrii , Shvydenko Andrii , Nekora Olga
Published: February 2025

The patterns of changes in the parameters of the movement of a part of a tank after separation from the bottom depending on its design parameters and the conditions of its filling were studied. Based on the conducted studies, a mathematical model of the separation process of a part of a tank was formed, which takes into account both geometric and physical nonlinearities of the material. The methods of mathematical modeling, numerical analysis and computer simulation were used for the selected study. Mathematical models allow for an accurate description of the stress-strain state, and numerical methods, in particular finite element and smoothed particle (SPH) methods, provide accurate modeling of the interaction between structural elements and the liquid. Numerical experiments were conducted using the LS-DYNA software package, which made it possible to determine the main parameters of the separation process, such as the maximum stresses in the welded joint zone and the distribution of deformations in the tank material. The results of numerical modeling showed that the main destruction occurs precisely in welded joints, due to the lower strength of the seam compared to the main tank material. This is consistent with the experimental data obtained in laboratory conditions. For a more detailed analysis, a full factorial experiment and regression analysis were conducted, which allowed us to identify the key factors that affect the separation process and establish empirical relationships between the load, material and geometry parameters of the samples. The constructed regression model demonstrates a high correlation between the selected factors and the separation parameters of the tank. The results obtained can be used to predict the behavior of steel tanks during a fire and develop recommendations to improve their safety and strength, taking into account the conditions of real operational loads.
Results of the heating of reinforced concrete slabs with a corrugated profile during the thermal effect of fire
Authors: Stepanenko Vitalii , Nuianzin Oleksandr , Perehin Alina , Kryshtal Dmitro , Kopytin Dmitro
Published: February 2025

Three experiments were conducted on heating fragments of reinforced concrete slabs with a corrugated profile in a small-sized installation and the results of the thermal effect of fire at control points were analyzed for the possibility of their use when assessing the fire resistance of the specified building structures. The methodology and results of experiments on heating frag-ments of reinforced concrete slabs with a corrugated profile and the study of the temperature on heated and unheated surfaces, in the reinforcement layer and at control points were substantiated. Conducting the above-mentioned experiments in a small-sized installation for the study of the thermal effect of fire on building structures without mechanical load consisted in the effect of the standard temperature regime of fire with one-sided heating. To measure the temperature in the furnace and in the investigated fragments, thermocouples were used, which can be used to measure temperatures in the range from 0 to 1300 ℃ and thermistors to measure temperatures in the range from -30 to 300 ℃. According to the conducted experiment, there was a uniform distribution of temperatures on the heating surface of the studied small fragment, the maximum temperature reached was 760 ℃. Maximum temperatures: at control points it was 145 ̊℃; on the unheated surface it was 45 ℃, and at the level of the armature – 350 ℃. Studies are limited to 60 minutes, since the temperature can then approach the stationary one. The adequacy of the experimental data was confirmed: the relative deviation did not exceed 4.1 %, and the calculated adequacy criteria (Fisher, Student and Cochrane) were below the critical value. The initial data of the experimental study can serve as the basis for reproducing the temperature field inside the slab.
Difference in Functional Outcomes Between Anterior Cruciate Ligament (ACL) Reconstruction Combined with Lateral Extra-Articular Tenodesis (LEAT) and Without LEAT Combination for ACL Injury Patients in the Third and Sixth Months Postoperative
Authors: Surya Pranata I Ketut Gede Arya , Astawa Putu , Bramantya Karna Made
Published: February 2025

Introduction: Anterior Cruciate Ligament (ACL) rupture is a common knee injury, particularly affecting young, active individuals. Reconstruction techniques for ACL injury, with or without Lateral Extra-Articular Tenodesis (LEAT), play a crucial role in determining patient outcomes. This study aims to compare the functional outcomes of ACL reconstruction with LEAT and without LEAT.
Materials and Methods: This retrospective cohort study was conducted from February 2023 to February 2024 at Prof. IGNG Ngoerah Hospital, involving 40 patients who underwent ACL reconstruction (18 with LEAT, 22 without LEAT). Patient outcomes were evaluated at 3, 6, and 12 months postoperatively using IKDC, Tegner, KOOS scores, and Rolimeter measurements. Statistical analysis included chi-square and independent t-tests to assess differences between the two groups.
Results: The baseline characteristics showed no significant differences between the groups, indicating no confounding factors. Males comprised 67.5% of the cohort, with the majority (72.5%) aged 18-30 years, and 57.5% were private sector employees. The most common injury mechanism was sports-related (50%). The most prevalent symptom was knee pain (52.5%). Statistically significant improvements were observed in the LEAT group compared to the non-LEAT group in KOOS, IKDC, and Rolimeter scores at both 3 and 6 months (p<0.001).
Conclusion: ACL reconstruction with LEAT demonstrated superior clinical and functional outcomes compared to reconstruction without LEAT, suggesting that this technique may provide enhanced stability, especially for athletes and individuals engaging in pivot-heavy activities.

Keywords: ACL reconstruction, Lateral Extra-Articular Tenodesis, functional outcomes, knee injury, sports medicine
Healthy Lifestyle for a Sustainable Future: A Study on Undergraduate Students
Authors: Das Bishal
Published: February 2025

The study aims to find out how health, sustainability and related factors such as – Physical Fitness (PHF), Mental Health (MEH), Emotional Health (EMH), Spiritual Health (SPH) factor along with Environmentalism (ENVM) and Social Consciousness (SOC) are connected in undergraduate students. using a descriptive survey approach, a sample of 393 students from Purulia district, West Bengal was analysed to investigate variations based on gender, academic stream, and place of residence. Differences in Lifestyle of Health and Sustainability (LOHAS) and associated dimensions were observed among male and female students, arts and science students, and rural and urban students. statistical analysis using Mahalanobis Distance revealed significant differences between arts and science student, while gender and place of residence showed no significant disparities. Emphasizing the role of academic streams in influencing these multidimensional health and sustainability factors.

Keywords: Environmentalism, Mental health, Spiritual health, Mahalanobis distance, Emotional Health, Physical fitness, Undergraduate students, Social Consciousness
Parental Engagement for Upbringing of Child in an Inclusive Set Up
Authors: Dey Binayak
Published: February 2025

This study highlights the significance of parental involvement in promoting the academic progress of children with disabilities within inclusive educational settings. Its aim was to explore how parents support their children’s learning, particularly those with special needs, and to identify the challenges they face. A thorough review of literature was conducted, followed by data collection from 48 parents through a self-structured questionnaire that highlighted the obstacles they encounter. The results demonstrate a strong link between parental involvement and academic success, especially for children with disabilities. Unlike typically developing children, children with disabilities significantly benefit from active parental engagement. However, barriers such as negative parental attitudes, financial difficulties, and a lack of awareness about the importance of involvement emerged as major challenges. The geographical distance between home and school, particularly for parents in remote areas, further restricts their ability to engage in school activities. This study emphasizes the importance of schools adopting inclusive communication strategies, offering necessary resources, and cultivating a supportive environment to encourage parental participation. Policymakers are urged to establish clear parental involvement policies that empower parents to actively engage in their children’s education. The findings underscore the critical influence of parental involvement on the academic success of children with special needs and call for a collaborative approach between parents, schools, and policymakers to ensure equal educational opportunities for all children. By fostering this partnership and embracing inclusive education, society can create an environment where every child, regardless of disability, has the opportunity to thrive.

Keywords: Parental Engagement, Upbringing of Child, Inclusive Set Up
Biomarker Mild Cognitive Impairment in Older Adults: A Review
Authors: Permata Dewi Komang Indah , Widyadharma I Putu Eka
Published: February 2025

Dementia and other neurodegenerative diseases are on the rise due to an ageing population; moderate cognitive impairment (MCI) is a precursor to the more serious illness. Measurable cognitive impairments that do not meet the dementia diagnostic criteria characterise mild cognitive impairment (MCI), with an annual conversion rate to dementia of 10–15%. Early detection is critical to mitigating this progression, yet standardized diagnostic criteria are lacking. This review investigates the role of plasma biomarkers, including BDNF, vascular endothelial growth factor (VEGF), microRNA (miRNA), and neurofilament light chain (NfL), in the detection and prediction of MCI in elderly populations.
A systematic literature search identified 11 studies published between 2014 and 2024 that met inclusion criteria. Evidence suggests that BDNF, a neurotrophin essential for synaptic plasticity, learning, and memory, is downregulated in MCI patients, though compensatory elevation in preclinical stages of dementia has been observed. VEGF, implicated in neuroprotection and angiogenesis, demonstrated inconsistent levels in MCI. Circulating miRNAs, including miR-206 and miR-132, were significantly upregulated in MCI, disrupting neuroprotective pathways through BDNF and SIRT1 downregulation. NfL, a biomarker of axonal injury, was consistently elevated in MCI patients and showed improved diagnostic specificity when combined with phosphorylated tau.
These findings underscore the potential of plasma biomarkers in improving early diagnostic precision for MCI. Integration of molecular markers into clinical frameworks could enhance screening efficacy and therapeutic targeting, though further research is necessary to standardize their application in routine medical practice.

Keywords: Biomarkers; Mild Cognitive Impairment
Social Construction of Youth in Gelangan Village Magelang City Towards the Jathilan Cultural Arts
Authors: Akbar Kautsar Irbah Falah , Setyowati Dewi Liesnoor , Atmaja Hamdan Tri
Published: February 2025

The exponential development of technology has had a significant social impact, notably among the younger generation. Smartphone addiction has increased individualism in society, lowering awareness of local culture preservation. However, an interesting phenomenon occurred in Gelangan Village, Magelang City, where the youth in the Jathilan Satrio Budhoyo Mudho community still maintain and preserve the traditional art of Jathilan. This research analyzed the social construction of youth in Gelangan Village towards Jathilan art. This research employed a qualitative approach involving the community mentors as the key informants. This research was conducted on the Jathilan Satrio Budhoyo Mudho art community in Gelangan Village, Magelang Tengah Sub-district, Magelang City, with data collection methods through observation, interview, and documentation. The results showed that the social construction of youth towards Jathilan art culture in the Jathilan Satrio Budhoyo Mudho art community in Gelangan Village illustrated a dynamic and complex process. In the internalization stage, the youth in this community adopt norms, values, and knowledge about Jathilan from their family and social environment. This process began early in life through stories, experiences, and direct practice involving parents and mentors. Furthermore, in the objectivation stage, the knowledge and values that the youth has internalized become a part of their objective reality. They began to play an active role in the Jathilan Satrio Budhoyo Mudho community through regular participation in rehearsals and performances. At the externalization stage, they expressed the internalized values and knowledge through tangible actions, such as organizing events, promoting Jathilan through social media, and teaching children in the community.

Keywords: Jathilan Traditional Art, Social Construction, Youth
Development of Web-Based Learning Media to Improve Digital Literacy in Coastal Communities
Authors: Ismawati Dwi , S. Fuadi Debi
Published: February 2025

This study aims to develop web-based learning media to improve digital literacy in coastal communities. The research method used is the ADDIE (Analysis, Design, Development, Implementation, Evaluation) development model. The research instrument is a questionnaire that is analyzed to measure the effectiveness of learning media on improving digital literacy. The results of the study indicate that the use of web-based media improves coastal communities' understanding of the use of digital technology in everyday life. The results of the questionnaire validity and reliability tests indicate that this media is feasible to use. This study contributes to the development of learning models that are appropriate to the needs of coastal communities to improve their digital skills.

Keywords: web-based learning media, digital literacy, coastal communities, ADDIE Model
Salivary Biomarkers in Oral Squamous Cell Carcinoma Diagnosis and Prognosis - A Review
Authors: Phairingdao Nunisa , Deka, Akshay Chandra, , Vidhya Srinivasan,
Published: February 2025

Objectives: The purpose of this study is to investigate the increasing prevalence and consequences of oral cancer, a leading cause of cancer-related deaths worldwide. To explore the role of salivary biomarkers, in the diagnosis and progression of oral squamous cell carcinoma. To emphasize the potential of salivary biomarkers for advancing diagnostic methods and improving treatment options for oral cancer.
Materials and Methods: A comprehensive review of the existing literature was conducted using databases such as Google Scholar and PubMed. Search terms included “Salivary Biomarkers,” “Oral Squamous Cell Carcinoma,” “Head and Neck Squamous Cell Carcinoma,” and “Adiponectin.” Articles were filtered based on parameters such as tumor location, relevance to the study, and study region.
Results: Emerging salivary biomarkers, such as cytokines, show potential in diagnosing oral squamous cell carcinoma. Adiponectin, an adipokine with anti-inflammatory and metabolic properties, was highlighted as a key regulator of the inflammatory environment and tumor progression in oral cancer.
Conclusions: Salivary biomarkers, particularly cytokines and adiponectin, hold promise as non-invasive tools for the early detection and diagnosis of oral squamous cell carcinoma. Large-scale clinical trials are necessary to solidify the utility of adiponectin and other salivary biomarkers in personalized diagnostic and treatment strategies.

Keywords: Adiponectin, Adipokines, Biomarkers, Tumor.
Analysis of Factors Affecting the Welfare of Rice Farming in Kota Datar Village Hamparan Perak Sub-District
Authors: Ramadhan Anggia , Fadlan Ahmad , Handoko Tarigan Muhammad
Published: February 2025

The purpose of this study was to analyze the factors affecting the welfare of rice farming in Kota Datar Village, Hamparan Perak District. The specific target of this research is to analyze the influence of variables as indicators of farm welfare such as land area, total production, education level, number of workers, capital, government policies, technology and price levels. So that it can show how much these factors affect the welfare of farming, especially rice farmers in Kota Datar Village, Hamparan Perak District. The hypothesis in this study is that variables such as land area, total production, education level, total labor, price level, capital, government policy and technology are relevant to affecting the welfare of farming in Kota Datar Village, Hamparan Perak District. And these relevant factors have a significant effect on the welfare of farming in Kota Datar Village, Hamparan Perak District. The materials that will be used in this research are: Quantitative Material, where the Quantitative Material in this study relates to data describing the estimated indicators of land area, total production, education level, total labor, price level, capital, government policy and technology. The data analysis used is: Confirmatory Factor Analysis (CFA) and Multiple Linear Regression. The results of this study explain that in the CFA test it is known that of the eight factors, it is feasible to influence the welfare of rice farming there are three factors, namely price, production and land area. The results of the partial hypothesis test show that price, production and land area have a significant effect on the welfare of rice farming in Kota Datar Village, Hamparan Perak District, Deli Serdang Regency.

Keywords: Factors, Welfare, Farm Business, Kota Datar Village
Insights into Menkes Disease: A Case report on Rare X-Linked Copper Metabolism Disorder Linked to ATP7A Mutation
Authors: R Dhanush , D Tejaswini , Bhandari Sourabha
Published: February 2025

Menkes’ disease (MD) is a X-linked recessive degenerative disorder, involving mutations of ATP7A gene, characterized by impaired copper transport at the intracellular level contributes to nervous system dysfunction. Clinical manifestations include brittle kinky hair, growth retardation, seizures and typical cherubic facial appearance. Here, we present a case of 1-year-old male with complaints of fever, excessive irritability, seizures like activity in form of up rolling of eyes and associated with postictal drowsiness passage of urine or frothing. MRI revealed brain abnormalities and final diagnosis with Menkes disease via genetic testing. Routine biochemical investigations were normal but copper and ceruloplasmin levels were found to be abnormal. Due to unavailability of copper histidine in our hospital and referred for further management. Symptomatically treated with Levetiracetam and biotin tablets. Reporting of this case is important, because of its rarity and association with association with significant microcephaly.

Keywords: Menkes disease, Kinky Hair Disease, ATP7A gene, Copper histidine
Factors Affecting the Performance of Users of the Regional Government Information System (SIPD) in the Regional Government of Tapanuli Utara Regency
Authors: Natalima Glory , Erwin Keulana , Br Bukit Rina
Published: February 2025

Information systems and technology use, particularly in urban areas, continues to increase. Implementing an Information System (IS) for Regional Governments (Pemda) aims to optimize regional financial management and digitalize public service management. This study aims to identify the factors influencing users' performance of the Regional Government Information System (SIPD) in the Regional Government of North Tapanuli Regency. This research adopts a quantitative approach, collecting data through questionnaires. The population and sample of this study consist of 90 individuals, comprising segment managers and cost program accountants in the Regional Government of Tapanuli Utara Regency. The data analysis technique used in this study includes descriptive statistical analysis and a structural equation model (SEM). The results of this study indicate that, partially, personal technical ability, top management support, training, and education have a positive and significant effect on the performance of SIPD users. Personal technical ability, top management support, training and education, and end-user satisfaction collectively influence the performance of SIPD users by 95,3%. In comparison, the remaining 4,7% is influenced by other variables not examined in this study.

Keywords: personal technical ability, top management support, training and education, end-user satisfaction, sipd user performance
A Rare Complication of Medial Femoral Condyle Fracture During Total Knee Replacement Surgery: A Case Report
Authors: Suryanto Dusak I Wayan , Meregawa Putu Feryawan , Hamzah Hendra Aryudi , Nanda Ustriyana Nyoman Gede Grenata
Published: February 2025

Intraoperative femoral condyle fractures during primary total knee arthroplasty (TKA) are exceedingly rare complications, with limited cases reported in the literature. These fractures pose significant challenges, requiring immediate and meticulous surgical intervention to ensure optimal outcomes. This case report highlights a rare instance of an intraoperative medial femoral condyle fracture encountered during TKA surgery, discussing its management and outcomes. Here we present a 59-year-old female with Kellgren-Lawrence grade IV bilateral knee osteoarthritis underwent right total knee arthroplasty. During the procedure, an avulsion fracture of the medial femoral condyle occurred while evaluating tibial and femoral component stability. The fracture was managed intraoperatively using two cancellous fully threaded screws with washers, achieving successful stabilization. Postoperative stability tests confirmed satisfactory results, and the patient underwent a tailored rehabilitation program. Radiological follow-up showed favorable outcomes, with the fracture healing adequately and the knee maintaining functional stability. This report adds to the limited data on intraoperative medial femoral condyle fractures during TKA and emphasizes the need for advanced planning, careful execution, and appropriate postoperative rehabilitation to ensure successful patient outcomes.

Keywords: Intraoperative fracture, Medial femoral condyle, Total knee arthroplasty, Surgical complication.
A Neuropsychiatric Analysis of a Delusional Syndrome I Am Dead- Walking Corpse Syndrome
Authors: Gope Mandira , Panda Soumya
Published: February 2025

Walking corpse syndrome is an infrequent state that is so far to be grouped as an illness. Nihilistic delusions regarding the personal body are the main characteristics of Cotard’s syndrome. Sick person with the walking corpse disorder, a scattered neuropsychiatric sickness, can have mistaken impression or false impression that their framework is reduced, interdiction reside, are crumbling aside, or have astray each of themself chief organs. They occasionally even have the capability to in hell the putrefying flesh. The sickness is for most categorized as “existence denial”. Guiltiness, worry, and negative feelings can sometime accompany it. Conversely, some ill person could be convinced they are undying. Both emotional and somatic conditions can origin Cotard’s syndrome, so profound distinctive work-up is required. Cotard’s syndrome in juveniles or adolescents appears to be connected escorted by bipolar condition. Intervention should be administered in the direction of the underlying causes. During the condition of depression with psychotic signs and symptoms, successful intervention with electroconvulsive therapy is regularly administrated. The two-factor model and the interactionist structure are the most essential causes hypotheses for misconception of misidentification, but empirical information for Cotard’s syndrome is scarce.

Keywords: Cotard’s syndrome, denial, Nihilistic delusion, Walking corpse syndrome, Neuropsychiatric illness.
Fingertip Injuries Conservative Management with Dressing: A Systematic Review
Authors: Yuda Asmara Anak Agung Gde , Dalem Pemayun Cokorda Krishna , Florencia Deslivia Maria , Florencia Deslivia Maria
Published: February 2025

Introduction: Fingertip traumatic injuries are known as the most common injuries to the hand. Conservative management is one of the treatment approaches that is purposed to promote secondary healing in fingertip injuries. This article reviews the current best evidences and concepts about recent developments in conservative management using dressing in fingertip injuries.
Methods: A literature search was carried out to determine potential studies for this review up to November 20th 2020. The search was performed using the PubMed/MEDLINE, Embase, Cochrane Library, and Google Scholar databases including keywords that matched the MeSH rule and the term used for fingertip injuries and conservative management.
Results: The search strategy generated several diverse literatures presenting a variety of conservative management in fingertip injuries. A total of 6 studies were included in the review. Satisfactory healing outcomes were found in most of the studies. Tissue healing as assessed by pulp regeneration was found in 4 of the 6 studies studied. Improvement of normal functions from the aspect of fingertip sensibility is also no different compared to non-conservative management. Satisfaction of aesthetic aspects were also found in the studies, although some complications can still be observed.
Conclusion: Conservative management with dressings allows patients to avoid long immobilization with satisfactory results in clinical healing outcomes, complication, and aesthetic measures. However, comparative studies are still limited; thus, further studies are needed to provide more advanced statistical result as to whether type of conservative management is superior to each other in fingertip injuries.

Keywords: fingertip injury, digital injury, conservative, dressing
Effect of Sleep Deprivation on Reaction Time Towards Visual Stimuli in Medical Students
Authors: Sameen Tariq  , Emaan Tindyala  , Aman Asif Butt  , Um Ul Baneen Zehra  , Hisham Tindyala  , Amna Yousaf  , Ayesha Aithesham  , Siddiqa Ayesha , Nageen Hussain
Published: February 2025

A descriptive cross-sectional study was conducted at Shalamar Medical & Dental College, Lahore, for 4 to 5 months. Through non-probability sampling, 264 students were selected for the study. MBBS students currently studying at Shalamar Medical and Dental College and attending classes at least 5 days a week were included in this study. The data were collected after obtaining the informed consent with the help of a questionnaire and psychomotor vigilance test. The data was entered and analyzed with SPSS version 22. Quantitative variables from the data set were analyzed by student t-test. A p-value of ? 0.05 was considered significant.Results: The difference between the mean reaction time of male subjects and that of the female subjects was non-significant with a p-value of 0.443. The difference between the mean reaction time of the subjects who were habitual caffeine consumers and those who were non-consumers was found to be significant with a p-value of 0.042.Lastly, the difference between the mean reaction time of subjects who slept less than 6 h and those who slept more than 6 h was non-significant with a p-value of 0.463. Gender has no role in the mean reaction time of medical students to visual stimuli, habitual caffeine intake shortens the reaction time and restricted sleep loss does not affect the psychomotor vigilance task.
Formulation and Evaluation of Polyherbal Medicated Lollipop for Paediatrics
Authors: Pundkar Ashwini S. , Vaidya Rohini R. , Ubale Kalpana P. , Sayyad Sayama M. , Ruke Sakshi S. , Sankaye Nikita R.
Published: February 2025

The goal of current work is to formulation and evaluation of medicinal lollipop for paediatrics. For paediatric patients, the traditional dosage forms-such as tablet, capsules, syrup, etc.-are inconvenient. Lollipops are characterised as medicinal dosage forms with flavours that are meant to be sucked and kept in the mouth or throat. These forms often contain one or more medications in a sweetend foundation. Due weather change and due to bronchial infection cough occurs in paediatric commonly and conventional dosage form is not suitable for paediatric. Most in children is caused by undifferentiated acute respiratory tract infections-a cough that does not conform to any clear diagnostic syndrome such as cough, whooping cough, pneumonia, or bronchiolitis. This medicated lollipop formulated with the help of Sitaphal powder, bamboo, pepper, cardamom, and cinnamon and prepared by heating and congealing method. This polyherbal lollipop prepared specially for diabetic children with the help of honey not by using sugar syrup base, because most of the lollipop prepared by using sugar syrup and it is inconvenient for diabetic children. Different evaluation parameter was performed like hardness, friability, weight variation and moisture content. Medicated lollipop passes all evaluation parameter.
Development and In vitro Evalution of Buccoadhesive tablets of Propranolol
Authors: Bommanchu Aparna , Kanukuntla Manga
Published: February 2025

Buccal tablets of propranolol were prepared by direct compression method using different hydrophilic polymers such as hydroxypropyl methylcellulose, sodium carboxy methylcellulose and Carbopol. All the prepared formulations showed satisfactory mass uniformity, thickness and favourable drug content. The friability of all the formulation was below 1%, which is an indication of good mechanical resistance of tablets. Among all the formulations, F4 showed maximum swelling index and in vitro release. Drug release mechanism was determined by plotting release data to Higuchi and Korsmeyer-Peppas model. All the formulations are best fitted to Higuchi model and according to this model the drug releases from theses tablets may be controlled by diffusion. The surface pH of all formulations was found to be almost in neutral pH and no mucosal irritation was expected. The accelerated stability studies indicated that, the selected formulation (F4) showed almost same drug content, mass uniformity and residence time. No colour change or no changes in texture were observed when tablets were tested in simulated saliva solution (pH 6.8).
Formulation and Evaluation of Deodorant Roll on Using Tamarindus indica Extract
Authors: Jabeen M. Afeefa , Jaleel Najuma , P.T. Devika , C.S. Anakha , A.T. Shifana , Saju Jilby
Published: February 2025

As the prevalence of increasing underarm problems associated with youngsters and the increasing side effects by the usage of synthetic deodorant because of the majority of ingredients are chemicals. The objective of study is to formulate herbal deodorant for controlling underarm problem associated with skin and to eliminate harmful synthetic ingredient from herbal deodorant formulations and substitute them with a safe natural ingredient is herbs and to evaluate herbal deodorant containing tamarind pulp extract. Antimicrobial activity of Tamarindus indica help to prevent itching, skin rashes, redness, pigmentation.
Common Weed Argemone mexicana as a Medicinal Jackpot:
An Overview
Authors: Thakare Santosh Kishor , Suryawanshi Vaishnavi Rajendra , Suryawanshi Saurabh Rajaram , Dode Raj Hemant , Deore Gaurav Shailesh
Published: February 2025

A Mexicana is weed belonging to papaveraceae family with great medicinal value. The present work gives a review to explore more about its chemical constituent and their pharmacological action. The plant A. mexicana have various pharmacological actions such as anticancer, antifertility, antifungal, antibacterial, antidiabetic, anti-inflammatory and many more the chemical constituent alkaloid, glycosides, terpenoids, flavonoids responsible for this pharmacological action.
Guardians of Wellness: Innovations Redefining Safety and Sustainability in Pharmaceutical Packaging
Authors: Gowda Shashank R , Venkatesh Ranjitha , Sreedhara Athmika
Published: February 2025

Packaging is a crucial task in the pharmaceutical sector. It serves the purpose of protecting and preserving items and communicating marketing and regulatory information to consumers. In the past, packaging requirements only focused on maintaining the quality of enclosed products. Packaging has become a significant factor in the food and drug markets. It must meet criteria such as stability and shelf life, convenience and compliance of product use, prevention of product tampering and counterfeiting, ensuring product safety, and brand identity.
The packaging should have a calming effect on users, complementing the healing properties of the medicine. As the packaging industry continues to evolve, industries are embracing innovations in this field to improve patient adherence to drug regimens. This article discusses the various aspects of pharmaceutical packaging, including the materials used, types of packaging, and recent trends in the pharmaceutical market.
Herbal Suppositorries as Saviour of Mankind; An Advanced Review
Authors: Rai Chandni , Tiwari Sweety , Singh Dhaker Kehar , Singhai Akhlesh Kumar
Published: February 2025

The internal organs are protected by the bodily cavities, which also act as a cushion against movement and a means of preventing the surrounding organs from changing size and shape without interfering with their ability to function. Suppositories are defined as such dosage forms that are designed as they are intended to be administered via body cavities such as rectal, vaginal, and urethral. Although advanced forms of suppositories are also given via nasal and ear route, they are made to produce better bioavailability of drugs at the targeted sites as compared to other conventional routes and forms. This review study primarily focuses on the area and features of suppositories that are made with herbal medication ingredients. This study describes the entire process of creating and evaluating herbal suppositories, and its primary focus is on the study of some novel diseases or conditions that are treated with these suppositories but are even harder to treat, cause toxicity, or demand high dosages to have the same therapeutic effects as other dosage forms. These herbal suppositories also produce pleasing and adorable results.
Vitamin-D Deficiency: Health Implications and Therapeutic Approaches
Authors: Abhiti Anugya , Saiyed Musaratafrin
Published: February 2025

Vitamin D deficiency, or Hypovitaminosis-D, is defined by 25(OH)D levels below 20 ng/mL, assessed via the 25-hydroxy vitamin D blood test. Major sources of vitamin D include sunlight, with limited sun exposure, skin complexion, dietary habits, and certain medical conditions contributing to deficiency. Notably, nearly half of the global population is affected, leading to increased mortality and various health issues. In India, vitamin D deficiency ranges from 40% to 99%, affecting diverse demographics, including the elderly, obese, nursing home residents, and hospitalized patients. Causes include poor sun exposure, specific diets, malabsorption syndromes, and certain medications. Vitamin D deficiency can lead to a host of health problems such as weakened immune function, fatigue, bone and muscle pain, osteoporosis, and mental health issues like depression. Specific conditions such as rickets in children and osteomalacia in adults are also linked to severe deficiency. Diagnosis is through blood tests measuring 25(OH)D levels, and treatment involves vitamin D supplementation. Management strategies include increasing sun exposure, consuming vitamin D-rich foods, and possibly using UV-B light therapy. Public health measures such as food fortification, awareness programs, and accessible testing facilities are recommended to address this widespread deficiency. Effective implementation and monitoring of these strategies are essential to reduce the global burden of vitamin D deficiency.
Tablet Evolution: Exploring Cutting-edge Technologies in Formulation and Development
Authors: Garg Anshika , Rathor Muskan
Published: February 2025

Pharmaceutical sciences contain a wide number of territories including drug disclosure, plan improvement, testing, wellbeing and regulatory affairs. In this period of development and progression, in drug conveyance for better clinical impacts regular dosage forms have still a solid hold and are generally well known taking all things together sorts of medicinal preparation for oral use. In the last several years, the writing in drug advancement has been expanded in an amazing way. There is a consistent improvement of the assortment of details which are planned by the patient consistency, actual similarity, and therapeutic efficacy to overcome the deficiencies or antagonistic impacts of the previous formulations. In the current review, authors have tried to sum up various sorts of progression associated with solid dosage form i.e. 3D tablets, digital pills, inlay tablets, quick-dissolving tablets, mouth-dissolving tablets, or dispersive tablets, etc. The advances in innovations associated with them have additionally been examined in brief.
Critical Insights into Polio Vaccination: Balancing Risks, Benefits and Future Directions
Authors: Tiwari Pratibha , Patel Pratixa
Published: February 2025

This review examines the World Health Organization's efforts to eradicate poliovirus (PV) through the use of Inactivated Polio Vaccine (IPV) and Oral Polio Vaccine (OPV). While OPV is effective in preventing disease and limiting transmission, it carries risks such as rare paralysis and the emergence of vaccine-derived strains. With Type 1 wild-type PV still a threat despite the eradication of Types 2 and 3, a strategic shift towards global IPV adoption is critical to eliminate these risks. The review highlights the challenges of vaccine development for immunocompromised individuals and explores the differing mechanisms, benefits, and drawbacks of IPV and OPV. It also addresses the complexities of vaccine manufacturing, emphasizing the need for ongoing research to support global eradication efforts. A comprehensive understanding of vaccination strategies is essential as the world moves towards a polio-free future.
Artificial Intelligence [AI] -The Game Changer in Pharmaceutical Industry
Authors: Fatima Mutawaqila Juveria , Parthiban C.
Published: February 2025

This review is done to understand the importance of Artificial Intelligence (AI) as Artificial intelligence (AI) is a branch of computer science that allows machines to work efficiently and analyze complex data. The research focused on AI has increased tremendously, and its role in healthcare service and research is emerging at a greater pace. The AI technologies in the healthcare industry include machine learning (ML), natural language processing (NLP), physical robots, robotic process automation, etc. AI capabilities are rapidly evolving within healthcare, with both clinical and operational implications for pharmacy. There are opportunities for AI to explore further in the field of pharmaceutical and healthcare research because of its ability to investigate enormous data from various modalities. Some of the current studies elaborate on the utilization of AI in healthcare and other sectors. AI focuses on producing intelligent modeling, which helps in imaging knowledge, cracking problems, and decision-making. Recently AI played an important role in various fields of pharmacy like drug discovery, drug delivery formulation, development, poly pharmacology, hospital pharmacy, etc. Ongoing disruptive innovations are paving the way for patients to receive faster and more accurate diagnoses, along with personalized treatment options. AI can research and cross-reference published scientific materials with alternative resources, including clinical trial results to develop drugs and discover new effective treatment methods for rare diseases.The future of AI in pharmacy looks promising, with ongoing research aimed at addressing existing gaps and enhancing the integration of AI tools into everyday pharmacy practice. As technology advances, pharmacists are likely to play an increasingly vital role in patient care through the effective use of AI, ultimately leading to improved health outcomes and more personalized healthcare services.
Microsphere in Novel Drug Delivery System - A Descriptive Review
Authors: Jit Tanmay , Mukherjee Saptarshi , Chowdhury Sailee , Nandi Gouranga , Chakraborty Jashabir , Shil Dibyendu , Roy Saumendu Deb
Published: February 2025

Microspheres are free-flowing, spherical particles made of synthetic polymers or proteins with an average size between 1 and 50 microns. A controlled drug delivery system that improves a medicine's therapeutic effectiveness can help solve some of the issues. One such method is the use of microspheres as medication carriers. Drugs are delivered specifically to the target place and their concentration is maintained there without side effects. It will take centre stage in cutting-edge medication delivery. Using microspheres, medications may be directed to certain bodily locations. A drug's degree of targeting can be determined by localizing it to a particular section of the body, such as the lungs, a certain cell type, such as Kupffer cells, or even intracellular structures, such as lysosomes or cell nuclei. The microspheres' medicinal effect is determined by the speed at which the medication releases from them. The chemical makeup of the polymer and the medication, the polymer's resistance to degradation, the microspheres' surface area and porosity, and their combined interactions all influence release. Depending on the microencapsulation technique used, the interior structure of the microspheres might change. Diffusion of the drug through a polymeric excipient and diffusion of the drug contained inside the pores of the polymeric microspheres allow for controlled drug release from the microspheres.
A Short Review on Description of Generic and Branded Drug
Authors: Patil Raghuveer V. , Shaikh Azam Z. , Jain Akash S. , Patil Divakar R. , Shaikh Sameer R. , Pawar S.P.
Published: February 2025

Healthcare spending on medications is rising due to advancements in medical care and increased diagnostic capabilities for conditions like high blood pressure and diabetes. Medicines are categorized into branded and generic drugs. A significant portion of healthcare spending is dedicated to medicines, with future costs expected to rise due to advancements in healthcare, improved diagnostics, and demographic changes. Medicines are primarily classified into branded and generic drugs. Branded drugs are original products developed by pharmaceutical companies and protected by patents, which grant exclusive manufacturing and marketing rights for a set period. This results in high production and marketing costs, leading to elevated prices. Once the patent expires, Generic drugs which are identical in form, strength, administration, quality, and therapeutic effect become available. Generics are produced at lower costs due to reduced manufacturing, marketing, and retailer expenses, making them a cost-effective alternative. Although generics might vary in appearance or taste due to different fillers, they are just as safe and effective as branded drugs. The adoption of generics is influenced by public policies aimed at reducing healthcare costs and can help lower overall expenditures while maintaining high care standards. By making generics more accessible, healthcare systems can potentially reduce overall costs while maintaining high standards of patient care.