bluuebunny/crossref_metadata_2025 huggingface dataset:
THE MOTIVES OF COSMOPOLITANISM IN THE LYRICAL COLLECTION “POET, OKEAN I RYBA” AND IN THE COLLECTION OF ESSAYS “UZDOVZH OKEANU NA ROVERI” BY VASYL MAKHNO
Authors: Hanchenko Anastasiya
Published: July 2023

In the article the attempt of comprehension the motives of cosmopolitanism in Vasyl Makhno`s work based on the material of the lyrical collection "Poet, okean i ryba" and the collection of essays "Uzdovzh okeanu na roveri" is made. On the basis of the texts of the collections the principles of author’s identification in the artistic world of lyrical works and essayistic texts are analyzed, based on the ideas of cosmopolitanism as universal human values that prevail over ethnic problems in the artist`s worldview. Furthermore, the origins of the idea of cosmopolitanism in Vasyl Makhno`s work are also substantiated, representing the formation and transformation of the author`s worldview as the Ukrainian author who lives on the American continent. Due to the categories of "presence" and "belonging" in place, the methods of reconstruction and reproduction of the author`s search for own identity are analyzed. In the article the topoi are examined through the category of “journey”, which are common and different in the artistic worlds of the lyric collection and the collection of essays, representing the author`s reflection through the category of "location". It is concluded that, while acting in various guises, among which the guise of "foreigner" is important, the author appears to the recipient as a cosmopolitan striving for harmony and the search for own "self". In the analyzed collections of lyric poems "Poet, okean i ryba" and the essays "Uzdovzh okeanu na roveri" by V. Makhno common and distinctive features of the reconstruction of space as a place for author`s and reader`s reflection are revealed.
KAZAKH CHILDREN’S LITERATURE IN THE FIELD OF INTERMEDIAL STUDIES
Authors: Nurmanova Zhanna
Published: July 2023

The article deals with the problems of intermedial interaction of different types of arts – music and literature, painting and literature based on the stories of M. Kabanbaev. The emphasis in the article is on the compositional structure and images of the characters. As a result of the study, the musical repertoire was identified, the correspondence between the musical form and composition of a prose work was determined, verbal music in prose was analyzed, which helps to recreate the specifics of musical experience. The importance of different types of arts in the life and work of Kazakh writers of the twentieth century is emphasized.
Constitutionalization and Protection of Traditional Values within the Framework of the 2020 Constitutional Reform
Authors:   Senior Lecturer of the Department of Theory and History of State and Law, Constitutional Law of the Novosibirsk State University, PhD (Law), Drobot Semen E.
Published: July 2023

Purpose: the actual and necessary legislative constitutionalization of traditional values, which include both the “morality” originally enshrined in the Constitution and the “historical truth” and “traditional family values” named during the constitutional reform of 2020, has not been developed in modern Russian constitutionalism, and therefore its implementation and harmonization with the freedom of creativity. Methodology: in the process of writing the article, the following methods were used: analysis, synthesis, system approach, formal legal. Conclusions: the current regulatory regulation shows a lack of legal protection of public morality and traditional family values. The development of legal protection of traditional values can be directed towards the legislative expansion of the grounds for interference in the cultural activities of citizens and organizations in order to harmonize freedom of creativity with constitutional values, as well as to empower regional and local public authorities to monitor compliance with the priorities of cultural development determined by the President of the Russian Federation. Scientific and practical significance: the conducted research makes it possible to supplement and improve the existing legal regulation in the field of cultural activities. The conclusions of this study can be used to amend and supplement regulatory legal acts regulating the powers of regional and municipal public authorities in the implementation of state cultural policy.
The Corruption Combating Information and Analytical Bulletin (2022). The Institute of Legislation and Comparative Law under the Government of the Russian Federation
Authors:   Head of the Faculty of Training of Academic and Research Personnel of the Kikot Moscow University of the Ministry of Internal Affairs of Russia, LL.D., Professor, Osokin Roman B.
Published: July 2023

The Institute of Legislation and Comparative Law under the Government of the Russian Federation has developed the Corruption Combating information and analytical bulletin (2022) that is a continuation of studies of application of corruption combating laws. The bulletin analyzes the data from the Register of Persons Dismissed in View of Loss of Trust and the data published in the Unified Register of Procurement Participants used as the basis to word conclusions and proposals for improvement of corruption combating measures.
Bacterias endófitas aisladas de cultivo de arroz con actividad promotora de crecimiento
Authors: Barboza García Adrián , Pérez Cordero Alexander , Chamorro Anaya Lina
Published: July 2023

En este trabajo se evaluó in vitro la actividad promotora de crecimiento de bacterias endófitas aisladas de diferentes tejidos de variedades de arroz del municipio Montería, departamento de Córdoba, Colombia. La población de bacterias endófitas se aisló en medio de cultivo agar R2A, se realizó conteo y se evaluó cualitativamente la capacidad de fijación de nitrógeno, solubilización de fosfato y producción de sideróforos. Las bacterias endófitas con actividades positivas fueron identificadas mediante secuenciamiento del gen ARNr 16S con 5 juegos de oligonucleótidos específicos para la clase firmicutes, beta-proteobacteria; gamma-proteobacteria; alfa-proteobacteria y actinobacteria. Se aislaron 107 morfotipo de bacterias endófitas con mayor presencia en la variedad 2000 y menor en la variedad 67; el tejido mayor colonizado correspondió a la raíz. De los 22 aislados, 11 mostraron capacidad de solubilizar fosfato, 6 de producir sideróforos, y 5 de fijar nitrógeno. Los resultados del secuenciamiento comprobaron la identidad de Bacillus cereus y B. thuringiensis, los cuales tienen la capacidad de promover el crecimiento en cultivo de arroz mediante la solubilización de fosfato, fijación de nitrógeno y producción de sideróforos.
Istiḥsān Method and Its Relevance to Islamic Law Reform: Content Analysis of Fatwa of Majelis Ulama Indonesia on Corneal Transplant
Authors: Johari Johari , Maghfirah Maghfirah , Maulidizen Ahmad , Rizapoor Habiburrahman
Published: July 2023

The progress of science in the field of medicine has brought immense advantages to human existence. Nonetheless, these advancements have both positive and negative consequences for humanity. They also give rise to deliberation and disagreement, particularly concerning Islamic jurisprudence, as not all medical technological breakthroughs can be embraced without reservation in society. This study is a descriptive, analytic, and comparative literature review. The ushuliy approach is employed to examine the methodology utilized by the two organizations in determining their stance on human corneal transplants. The primary source material used in this research is the fatwa issued by Majelis Ulama Indonesia in 2009 regarding Corneal Transplants. The data for this research was collected through a documentation method, which involves gathering information from various articles and books. The collected data was then analyzed using content analysis, which involves a descriptive and scientific examination of the key messages. The findings of this study reveal that Majelis Ulama Indonesia holds the view that corneal transplants can be performed on individuals in need, with the intention of Tabarru' (acts of charity), if there are no alternative medical options available, based on the principle of Maslahah (benefit or public interest).
Methanol extract of Bauhinia forficata leaves reduced serum creatinine level and prevented the elevation of hepatic enzymes in mice exposed to gentamicin and acetaminophen: an exploratory study
Authors: Funes-Rivera Sebastián , Kennedy María L. , Galeano Antonia K. , Funes Torres Patricia M. , Campuzano-Bublitz Miguel A.
Published: July 2023

Kidney and liver diseases are a public health problem worldwide. Pharmacological management usually prevents its progress even if indirectly. Currently, more alternative treatments based on traditional medicine and medicinal plants are considered. Bauhinia forficata is widely distributed in South America and is used for its hepatoprotective and nephroprotective properties. This study was designed to preliminarily assess the nephroprotective and hepatoprotective effect of the methanol extract of B. forficata leaves (50, 100, 200, and 400 mg/kg, per os) in Swiss albino mice. Acute kidney injury was induced with gentamicin (135 mg/kg, intraperitoneal), followed by determination of creatinine, urea, uric acid, and electrolyte levels in urine and serum. Acute liver damage was induced by acetaminophen (300 mg/kg, intraperitoneal), followed by determination of a serum liver profile of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. All tested doses of the extract were able to induce a significant reduction in serum creatinine levels, compared to untreated animals. Moreover, the extract effectively prevented the elevation of hepatic enzyme activity induced by acetaminophen. It is concluded that the extract of B. forficata leaves has nephroprotective and hepatoprotective effects in a mouse model of hepato and nephrotoxicity, which is compatible with traditional use.
Desafios contemporâneos para formação
Authors: Barros Maria Elizabeth Barros de , Rocon Pablo Cardozo
Published: July 2023

Este ensaio problematiza, a partir das formulações de Luiz Antônio Baptista sobre os amoladores de faca e de Judith Butler em sua discussão sobre reconhecimento e aparecimento público, práticas e perspectivas de formação e cuidado em saúde pautadas em discursos que pregam noções de um humanismo que podem amolar facas que produzem morte de determinados grupos sociais. Indaga modos de trabalhar em saúde que contribuem para fortalecer uma assepsia social que pode reduzir o viver a moldes apriorísticos de existência. Indica que esse processo tem emergência muito antes dos bancos escolares, mas pode ser fortalecido por padrões educacionais que fortalecem uma perspectiva asséptica. Encerra pensando sobre o presente, a pandemia de covid – 19, processos e caminhos possíveis para a produção de dispositivos de formação, cuidado e gestão em saúde que recusem um mandato social de amoladores(as) de faca. O artigo busca, enfim, forjar estratégias para a produção de um comum entre trabalhadores(as) e usuários(as), que defendam uma vida com suas diferenças e sua potência heterogenética.
Encruzilhadas de gênero em um currículo-museu
Authors: Alves Cláudio Eduardo Resende , Paraíso Marlucy Alves
Published: July 2023

Este artigo é resultado de uma pesquisa que investiga o que chamamos de currículo-museu com gênero e suas possibilidades de aprender no acervo do Memorial Minas Gerais Vale em Belo Horizonte/MG. A partir dos estudos pós-críticos de gênero e currículo foi utilizada a metodologia do diário de campo e da observação participante do cotidiano do museu. O objetivo foi mapear possibilidade de aprender com as “encruzilhadas de gênero” no museu, isto é, aqueles momentos em que as normas de gênero são colocadas em xeque. Foram selecionados uma máquina de costura e um regador de metal como elementos problematizadores na pesquisa teórica e empírica. Os resultados indicam que um currículo-museu pode oportunizar encontros múltiplos ao produzir deslocamentos no aprender sobre gênero. Por fim, o estudo aponta a relevância de uma prática curricular permeável às diferentes leituras de mundo e aos diferentes modos de existir.
Preconceito e discriminação com as mulheres no cenário brasileiro de esportes eletrônicos
Authors: Lima Pedro Henrique Rocha , Furlan Cássia Cristina
Published: July 2023

Objetivamos estudar preconceitos e discriminações sofridos por mulheres nos jogos eletrônicos. Para o levantamento de dados, o método utilizado foi um questionário misto online, desenvolvido através da plataforma de formulários do Google, o Google Forms, e divulgado em redes sociais, exclusivamente em grupos de integrantes de alguns e-Sports, para serem respondidos por mulheres, visando a obtenção de informações sobre acontecimentos envolvendo discriminação/preconceito dentro ou relacionado ao ambiente virtual de jogos. Participaram do estudo 110 mulheres, com idades entre 15 e 30 anos, de diferentes regiões do país. Entre os resultados encontrados, notamos que a sociedade virtual é certamente tóxica e misógina, e as mulheres precisam buscar métodos de camuflagem para conseguirem desfrutar dos jogos e e-Sports de forma prazerosa. Nesse contexto, há a necessidade de pensarmos ações, no âmbito educacional, para buscar minimizar e combater ações discriminatórias, preconceituosas e violentas, dentro e fora do ambiente virtual.
Časovno pojavljanje življenjskih prehodov, njihovi vzorci in napovedniki med prehodom v odraslost in odraslostjo v kontekstu spreminjajoče se družbe
Authors: Millová Katarína
Published: July 2023

Študija se osredotoča na življenjske prehode in njihove psihološke napovednike v kohorti odraslih, ki so odraščali v času velikih makrosocialnih sprememb v češki družbi. Vzdolžna študija Generation 2020 je sledila nekdanjim študentom od leta 2007. Prvi zajem podatkov je potekal, ko so bili udeleženci stari med 18 in 32 leti, drugi zajem pa takrat, ko so bili stari med 29 in 43 leti. V prvem zajemu so udeleženci izpolnili vprašalnike o identitetnih slogih, nadzoru nad čustvi in samoučinkovitosti (v smislu zaznanega nadzora). V drugem zajemu so izpolnili Koledar življenjske zgodovine, ki se je osredotočal na časovno pojavljanje večjih življenjskih prehodov, kot so odselitev iz gospodinjstva staršev, začetek sobivanja s partnerjem, poroka, starševstvo in redna zaposlitev. Analiza latentnih razredov je odkrila štiri vzorce življenjskih prehodov: na delo osredotočeni samski posamezniki, normativno časovno pojavljanje, osredotočeni na družino ter osredotočeni na družino z zakasnjenim partnerstvom in oblikovanjem družine. Nadaljnje analize so pokazale, da nadzor nad čustvi in samoučinkovitost nista bila povezana z nobenim od vzorcev prehodov, so pa bili pomembni napovedniki različni identitetni slogi, še posebej pri vzorcih prehodov, povezanih z zgodnjim pojavljanjem poroke in oblikovanja družine. Rezultati kažejo na nekatere spremembe v vzorcih življenjskih prehodov v primerjavi s starejšimi kohortami in na pomembnost samozaznav za kasnejše psihološko delovanje ljudi.
Evaluation of insertion and deletion polymorphisms of Brazilian Odontoceti
Authors: Abreu dos Anjos Dafne Adriana , dos Santos Donato Anna Luiza , Goldenberg-Barbosa Rodrigo , de Carvalho Elizeu Fagundes , Leal do Amaral Cesar Rogerio
Published: July 2023

Brazilian Odontoceti strandings provide substantial information about distribution, health, and genetics of this suborder. Moreover, molecular identification is required and studies in this area have been developed to clarify their distribution and phylogeny, since morphological identification may be infeasible in some degraded samples. In this study, we performed an in silico analysis of InDels in 16S rRNA from 27 species of toothed whales, dolphins, and porpoises present in Brazilian waters and recurrently found stranded in the region. We accomplished the species’ identification based on the unique SpInDel profile for all Odontoceti species, except Phocoenas, and for six species of delphinids.
Zakat Al Fitr Management and Information System using Agile Software Development Lifecycle
Authors: Uriawan Wisnu , Ramadhan Faizal , Azhar Haikal , Hasna Dian , Argani Farzan
Published: July 2023

Abstract—The management of zakat in several mosques is still carried out using a manual system, which can cause the loss of some zakat recipient data and the calculation of funds that have been received by zakat recipients. The manual system is also considered less efficient for managing large amounts of data. To overcome this renowned problem, a Zakat management infor- mation system was designed. Agile methods are used in system development. It is hoped that this system will provide convenience to mosque administrators in managing zakat. We created a zakat management system using Agile Software Development Lifecycle which can make it easier to manage zakat at the al-iklas mosque
The Medical Significance, Epidemiology, Pathogenesis, Detection, and Management of Respiratory Syncytial Virus
Authors: Suresh Shobith
Published: July 2023

Respiratory syncytial virus (RSV) is a common respiratory virus that can cause mild to severe illness in people of all ages. The most common symptoms of an RSV infection are cough, runny nose, and fever. However, RSV can also cause more serious complications, such as tracheobronchitis, bronchiolitis, pneumonia, and apnea. RSV is especially dangerous for infants, young children, and older adults. RSV is a seasonal virus, with peak incidence in the winter months. The virus spreads through respiratory droplets produced when an infected person coughs or sneezes. The virus can also be spread through contact with contaminated surfaces. Treatment is aimed at relieving symptoms and preventing complications. This review will provide an overview of the medical significance, virology, pathogenesis, immunity, epidemiology, symptoms, risk factors, and complications associated with RSV, and the diagnosis and management of RSV infections.
The Genetic Puzzle of a SOD1-Patient with Ocular Ptosis and a Motor Neuron Disease: How Many Variants Contribute to the Phenotype?
Authors: Vacchiano Veria , Palombo Flavia , Ormanbekova Danara , Fiorini Claudio , Fiorentino Alessia , Caporali Leonardo , Mastrangelo Andrea , Valentino Maria Lucia , Capellari Sabina , Liguori Rocco , Carelli Valerio
Published: July 2023

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex genetic architecture, showing monogenic, oligogenic, and polygenic inheritance. In this study, we describe the case of a 71 years-old man diagnosed with ALS with an atypical phenotype, due to the presence of a progressive ocular ptosis. Genetic analyses revealed two variants in SOD1 and TBK1 genes respectively and the LHON-associated m.14484T>C variant in the mitochondrial DNA (mtDNA). We discuss how all these variants may synergically impinge on mitochondrial function, contributing to the pathogenic mechanisms which might ultimately lead to the neurodegenerative process, possibly influencing the clinical ALS phenotype.
Experimental Study on Chromaticity Control in Visible Light Communication Systems
Authors: Ke Xizheng , Wang Xingxing , Qin Huanhuan , Liang Jingyuan
Published: July 2023

In order to apply visible light communication systems in different scenarios, this article utilizes an excellent temperature adjustable light source mixed with RGB LEDs, and applies it in a visible light communication system. It utilizes color division multiplexing technology to achieve three-channel communication, thereby improving the communication bandwidth of the system. The communication system adopts three constant current driving circuits to control the duty cycle of Pulse Width Modulation (PWM) of each channel, thereby changing the proportion of RGB LEDs, and obtaining different color temperatures to achieve the purpose of color control for mixed color LEDs. The experimental results show that when adjusting the color temperature, the change in luminous flux is very small, with fluctuations of less than 2.24%; When adjusting the brightness, the color temperature fluctuation is within 40K, which is less than the 50K color temperature limit that the human eye can distinguish, and the average color temperature error is 0.609%; Color tolerance less than 5.5×10-3 indicates good dimming effect, and the communication performance of the system is better in the high color temperature range, which is significantly superior to the low color temperature range. When the error rate is below 3.8×10-3, the total modulation bandwidth of the three channels reaches 11.7 MHz.
Challenges and Solutions in the Management of Hepatocellular Carcinoma Associated with Non-Alcoholic Fatty Liver Disease
Authors: Cadar Ramona , Lupascu Ursulescu Corina , Vasilescu Alin Mihai , TROFIN ANA MARIA , Zabara Mihai , Rusu-Andries Delia , Ciuntu Bogdan , Muzica Cristina , Lupascu Cristian Dumitru
Published: July 2023

Non-alcoholic fatty liver disease (NAFLD) has gained attention in the last few years due to its increasing prevalence worldwide becoming a global epidemic. This review aims to discuss the latest recommendations regarding diagnosis and treatment of NAFLD-associated HCC and the remaining challenges. Thus, there is a high amount of data derived from basic and clinical studies that revealed the molecular pathways which drive NAFLD-associated hepatocellular carcinoma (HCC). Based on these findings, new prevention, surveillance and treatment strategies are emerging. However, current data on treatment modalities in NAFLD-associated HCC are still scarce, but based on subgroup analysis results from non-NAFLD HCC studies are promising and could provide a basis for future research agenda to address NAFLD/NASH patients. Conclusion: Due to the pandemic proportions that NAFLD gained in the last few years, there is a high amount of data derived from basic and clinical studies that revealed the molecular path-ways which drive NAFLD-associated HCC. Based on these findings, new prevention, surveillance and treatment strategies could be developed at an individual level.
Feasibility of targeted antiviral therapy for acute respiratory viral infections in the COVID-19 pandemic
Authors:   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Omarova Kh.G. , Balykova L.A. ,   Ogarev Mordovai State University, Saransk, Russian Federation, Pshenichnaya N.Yu. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Zemskov D.N. ,   Ogarev Mordovai State University, Saransk, Russian Federation, Zaslavskaya K.Ya. ,   Ogarev Mordovai State University, Saransk, Russian Federation, Taganov A.V. ,   Russian Peoples' Friendship University (RUDN), Moscow, Russian Federation, Belyy P.A. ,   A.I.Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
Published: July 2023

The aim of this study was to analyze the efficacy and safety of using etiotropic therapy with favipiravir and molnupiravir that can selectively bind and inhibit not only SARS-CoV-2 proteins but also other RNA-containing pathogens of acute respiratory diseases. High transmission of pathogens, the risk of becoming chronic, frequent complications, cases of co-infection with several pathogens, which can lead to a more severe course of the disease, insufficient vaccination effectiveness, all this requires additional strategies for both prevention and treatment of acute respiratory viral infections. RNA-dependent RNA polymerase (RdRp), which has no equivalent in human cells, is involved in RNA synthesis and is an excellent therapeutic target for diseases caused by RNA viruses, including SARS-CoV-2. The long process of drug development and the “reuse” of drugs approved for other indications or successfully tested in terms of safety and tolerability pose the challenge of rapid establishment of an effective drug, including for the treatment of severe cases of COVID-19. Key words: COVID-19, SARS-CoV-2, RNA-dependent RNA polymerase (RdRp), favipiravir, molnupiravir
Clinical case of atypical presentation of Clostridium difficile infection combined with enterobiasis in a 14-year-old child
Authors:   Samara State Medical University, Samara, Russian Federation, Pechkurov D.V. , Romanova A.A. ,   Samara State Medical University, Samara, Russian Federation, Tyazheva A.A. ,   Samara State Medical University, Samara, Russian Federation
Published: July 2023

Clostridium difficile infection is currently a serious medical and epidemiological problem due to a significant and steady increase in the incidence of this pathology. An important causal factor in the increased incidence of Clostridium difficile infection is a widespread and often uncontrolled use of antibiotic therapy. The difficulty in diagnosing Clostridium difficile lies in a wide range of clinical manifestations of this infection, from mild diarrhea to pseudomembranous colitis, toxic megacolon, colon perforation, and multiple organ failure, resulting in a high mortality rate and prolonged length of stay in intensive care units. This article presents a clinical case of Clostridium difficile-associated infection in a 14-year-old boy. An important diagnostic feature of this case is the chronic course of infection, the clinical picture being dominated by pain, hyperthermia, and intoxication without diarrhea, as well as the presence of enterobiasis. This clinical example shows that Clostridium difficile-associated infection does not always present with diarrhea. The etiology of the disease in this case was confirmed not only by the detection of specific Clostridium difficile toxins in the patient’s stool samples, but also by clear positive dynamics with the administration of etiotropic therapy. This article describes the stages of differential diagnostic search and the choice of treatment tactics for Clostridium difficile infection. Key words: clostridium infection, children
Purulent meningitis and ischemic stroke resulted from large vessel occlusion in a child with generalized infection caused by Haemophilus influenzae
Authors:   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation, Gorelik Е.Yu. , Skripchenko N.V. ,   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Vilnits A.A. ,   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Marchenko N.V. ,   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation, Vasilieva Yu.P. ,   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation, Astapova A.V. ,   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation, Skripchenko E.Yu. ,   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Markova K.V. ,   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation, Voitenkov V.B. ,   Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation
Published: July 2023

The problem of generalized infection caused by Haemophilus influenzae is highly relevant to pediatric practice because of the disease severity and diversity of clinical manifestations. Purulent meningitis is the most common and most severe invasive form of infection caused by Haemophilus influenzae type b (Hib) and accounts for 50% of all cases. Purulent meningitis in children is characterized by high mortality and high incidence of residual neurological complications that often result in disability. The main cause if it is neurological complications in the acute period of the disease. In this article, we report a case of generalized Hib-infection, purulent meningitis, and a rare complication–thrombosis and occlusion of the large vessels, which caused acute cerebral ischemia/hypoxia. The combination of modern diagnostic methods, primarily neuroimaging, allowed us to verify the diagnosis at an early stage and ensured timely initiation of the appropriate therapy in order to prevent ischemic/hypoxic brain lesions. Parenteral injections of medications that increase the resistance of neurons and glial cells to hypoxia, such as cytoflavin, reduced neuronal damage in the acute period and residual neurological disorders during convalescence. Key words: vaccination, Haemophilus influenzae, purulent meningitis, children, complications, cytoflavin.
Vaccination of premature newborns: real clinical practice
Authors:   Siberian State Medical University, Tomsk, Russian Federation, Khodkevich P.E. , Kulikova K.V. ,   I.D.Evtushenko Regional Perinatal Center, Moscow, Tomsk, Russian Federation, Deev I.A. ,   Federal Research Institute for Health Organization and Informatics, Moscow, Russian Federation, Fedorova O.S. ,   Siberian State Medical University, Tomsk, Russian Federation, Kulikov E.S. ,   Siberian State Medical University, Tomsk, Russian Federation
Published: July 2023

Objective. To analyze the vaccination coverage and adherence to the vaccination schedule among premature newborns with a birthweight of <2,500 g. Patients and methods. This study included 119 children aged 5 to 6 years followed up within the "National prospective multicenter cohort study of newborns" in Tomsk. The experimental group comprised 96 children born prematurely, including 36 low-birthweight (LBW), 25 very low-birthweight (VLBW), and 36 extremely low-birthweight (ELBW) children. The control group included 23 healthy children born full-term. We analyzed their clinical data and information on vaccination. Results. The number of children who had completed their vaccination by the age of 5 years varied across the groups: 34.8% of controls; 16.7% of LBW children; 28% of VLBW children; and 17.1% of ELBW children (p > 0.05). Thirteen percent of controls and 5.6% of LBW children were timely vaccinated, whereas none of the VLBW and ELBW children had their vaccination in time. We observed no differences in the vaccination profiles (types of administered vaccines) between the VLBW children and controls; vaccination profiles of the LBW and ELBW children were similar. ELBW children were less likely to be vaccinated against tuberculosis, pertussis, diphtheria, tetanus, and polio than controls (p < 0.01). None of the ELBW children received vaccines against hepatitis B, pertussis, diphtheria, and tetanus, as well as third vaccine against polio at birth. In the rest of the groups, the proportion of timely vaccinated children did not exceed 20%. Parents in the control group were less likely to refuse vaccination for their children than those in the experimental group. Non-adherence to the vaccination schedule was more common in the LBW children. VLBW and ELBW children had medical exemptions more frequently than LBW children and controls. Conclusion. We observed low vaccination coverage among premature newborns for all vaccines caused both by medical exemption and non-adherence to the vaccination schedule. Key words: vaccination, premature newborns, extremely low birth weight
Quantitative HBsAg and HBV DNA levels: correlation in pregnant women with hepatitis B virus infection in Southern Viet Nam
Authors:   Pasteur Institute in Ho Chi Minh City, Ho Chi Minh, Viet Nam, Nguyen M.N. , Pham T.D.H. ,   Pham Ngoc Thach University of Medicine, Ho Chi Minh, Viet Nam, Nguyen T.T.H. ,   Pasteur Institute in Ho Chi Minh City, Ho Chi Minh, Viet Nam, Khuu V.N. ,   Pasteur Institute in Ho Chi Minh City, Ho Chi Minh, Viet Nam, Le M.H. ,   Hospital for Tropical Diseases, Ho Chi Minh, Viet Nam, Le Q.T. ,   Tu Du Hospital, Ho Chi Minh, Viet Nam, Chau M.D. ,   Dong Thap General Hospital, Dong Thap Province, Viet Nam, Nguyen V.N.T. ,   Pasteur Institute in Ho Chi Minh City, Ho Chi Minh, Viet Nam, Tran N.H. ,   Pasteur Institute in Ho Chi Minh City, Ho Chi Minh, Viet Nam, Hoang Q.C. ,   Pasteur Institute in Ho Chi Minh City, Ho Chi Minh, Viet Nam
Published: July 2023

Serum HBV DNA levels reflect the ability of hepatitis B virus (HBV) to spread and replicate. In pregnant women, when HBV DNA levels are more than 200,000 IU/mL, they are advised to use antiviral therapy to prevent mother-to-child transmission (MTCT). However, the HBV DNA test is expensive and not available in all health facilities. Quantitative HBsAg (qHBsAg) assay is cheaper and may replace the HBV DNA test. Objective. To determine the correlation between qHBsAg and HBV DNA levels in pregnant women. Patients and methods. Pregnant women with HBV were recruited in three hospitals from October 2019 to November 2020. A total of 665 women were examined. Among them, 417 women in the quantification range of HBV DNA test were selected for analysis. The mean age was 29.30 years (range: 18–43). The blood samples were taken for the qHBsAg assay and viral load test. The qHBsAg test was quantified by electrochemiluminescence, and the viral load test was measured by a real-time polymerase chain reaction (RT-PCR). Results. There was a strong correlation between qHBsAg and HBV DNA levels (r = 0.64, p < 0.001; n = 417). The correlation was strong in the HBeAg-positive group (r = 0.79, p < 0.001; n = 112), and there was no correlation in the HBeAg-negative group (r = 0.06, p = 0.41; n = 177). This correlation was stronger in the group of young women (18–35 years old) than in the group of older women (36–43 years old). Conclusion. In pregnant women with HBV infection, qHBsAg and viral load levels had a positive correlation, especially in the HBeAg-positive and the young women groups. The qHBsAg assay may replace the HBV DNA test when deciding on antiviral treatment in facilities with limited conditions to prevent MTCT. Key words: hepatitis B virus, quantitative HBsAg, HBV DNA test, pregnant women, mother-to-child transmission
Treatment of Symptomatic Residual Deformity in Legg-Calvé-Perthes Disease
Authors: Novais Eduardo N. , Ferraro Samantha L. , Justo Pedro G. , Ferrer Mariana G. , Miller Patricia , Kim Young-Jo , Millis Michael B.
Published: July 2023

Background:

Treating patients with symptomatic hips after healed Legg-Calvé-Perthes disease (LCPD) is challenging, mainly because of the complexity of the deformity. We performed a retrospective study to evaluate clinical and radiographic outcomes, measure the survival rate, and identify predictors of failure following a surgical hip dislocation (SHD) with femoral-head reshaping and relative femoral-neck lengthening for the treatment of symptomatic residual hip deformity after healed LCPD.

Methods:

We identified 60 patients undergoing SHD for the treatment of symptomatic residual LCPD deformity. Fifty-one (85%) of the patients (mean age, 16.3 ± 4.7 years; 21 male patients [41%]), were followed ≥4 years after surgery. We defined surgical failure as conversion to, or recommendation for, total hip arthroplasty (THA) or a Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score of ≥10 at the most recent follow-up. We used a multivariable Cox proportional hazards model to identify factors that were predictive of failure. The rate of survival free from failure was estimated using a Kaplan-Meier curve.

Results:

Twenty (39%) of the patients met 1 of the end-point criteria for surgical failure, while the hips of the remaining 31 (61%) of the patients were successfully preserved at a median follow-up of 10.2 years (interquartile range, 5.7 to 12.9 years). The estimated survival was 80% (95% confidence interval [CI] = 70% to 92%) at 5 years and 66% (95% CI = 53% to 81%) at 10 years. Independent factors associated with surgical failure were the severity of preoperative pain as assessed by the WOMAC pain score (hazard ratio [HR] = 1.16; 95% CI = 1.03 to 1.30; p = 0.01) and the severity of the deformity as assessed by the anteroposterior alpha angle (HR = 1.06; 95% CI = 1.01 to 1.11; p = 0.01).

Conclusions:

We found that SHD with relative femoral-neck lengthening and osteochondroplasty of the femoral head-neck junction was associated with improved deformity as assessed radiographically and decreased pain and symptoms of stiffness among patients with symptomatic residual LCPD deformity. Preoperative pain and deformity were identified as predictors of surgical failure. Further research is needed to establish the role of SHD and other procedures in preserving the hip over the long term.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Transitar del telar al palillo:
Authors: Miranda Carvajal Carlos
Published: July 2023

El presente trabajo busca conocer cómo la experiencia de escolarización de los comuneros lickanantay afectó al desarrollo de su identidad como indígenas después de ser sometidos a migraciones educativas dentro y fuera de los territorios ancestrales. Metodológicamente se usó la técnica de análisis de contenido, que incluyó modelos etnográficos a nivel de trabajo de campo y autoetnográficos a nivel de análisis. Se propuso una investigación decolonial relacionada directamente con la identidad indígena de los participantes e investigadores, y se observó una posición de investigador militante en el proceso social de reivindicación de los saberes ancestrales. Como principal conclusión se encontró que la escuela actuó como un dispositivo de control y de asimilación, efectos que fueron intencionados por los procesos de la instalación de un Estado unificado.
Entre resistencia y statu quo
Authors: Bresolin Elettra
Published: July 2023

Aunque se ha vuelto sumamente importante estudiar el fenómeno del escepticismo (o negacionismo) climático desde las ciencias sociales, la mayoría de los estudios revisados descuidan sus dimensiones culturales. El objetivo de este artículo es individuar los imaginarios que se construyen y circulan sobre el cambio climático en el grupo de Facebook «Watts Up With That?» y las narrativas que se utilizan para sostenerlos discursivamente. A través de un análisis de las publicaciones y discusiones en el grupo, muestro que estas alimentan un discurso escéptico en el que algunos temas recurrentes crean un panorama moral bastante polarizado, y se discuten dentro de un entorno de autolegitimación y rechazo del discurso científico oficial. Como conclusión principal, propongo que el negacionismo climático representa una defensa del statu quo vigente, y construye un imaginario ambiental basado en la separación entre seres humanos y naturaleza, y en la narrativa ilustrada del progreso infinito
Design, Analyze and Implementation of a Circular Shape Microstrip Patch Antenna at 2.4 GHz for Wireless Communications
Authors: Khidhir Ali
Published: July 2023

Having the correct antennas is one of the most important aspects of maintaining a successful wireless network. Antennas exist in a variety of shapes and sizes, each with its own purpose. A circular patch antenna with a 2.4 GHz resonance frequency was proposed and realized in this research. This project is divided into two theoretical and practical parts. In the theoretical part, the required antenna was designed and simulated through the use of mathematical formulae and specific algorithms to achieve optimal accuracy of the specified resonance frequency. The MATLAB computer language was also used to create and design a graphical interface that calculates the basic measurements necessary by the GUIDE to design the circular antenna utilized. In addition, The computer simulation technology (CST) program is used in the simulation process is used to build the needed model and test it digitally before implementation. After the simulation, computerized numerical control (CNC) is used to manufacture the printed circuit board (PCB). The antenna used is made on flame resistant (FR-4) material to perform this work. The experimental results showed the most important parameters related to the desired antenna such as At 2.360 GHz, the return loss (RL), bandwidth (BW), voltage standing wave ratio (VSWR), and input impedance (Zin) are − 25.72 dB, 48 MHz, 1.1092, and 53, respectively (from 2.338 to2.386 GHz). These results are close to the simulation values ​​mentioned in this research. As a result, the antenna used has good Wi-Fi performance and is desirable, Bluetooth, Zigbee, and cellular phone frequency bands (2.4 GHz) are examples of wireless communication applications phones. The purpose of this work is to improve some of the important parameters related to the quality of the proposed antenna, such as the total efficiency, gain, voltage, and input impedance, as mentioned above. These findings were confirmed by comparing them to the findings of others.
A zero-emissions global transportation sector: Advanced technologies and their energy and environmental implications
Authors: Speizer Simone , Fuhrman Jay , Aldrete Laura , George Mel , Kyle Page , Monteith Seth , McJeon Haewon
Published: July 2023

Currently responsible for over one fifth of carbon emissions worldwide, the transportation sector will need to undergo a substantial technological transition to ensure compatibility with global climate goals. Few studies have modeled aggressive strategies to achieve zero emissions across all transportation modes, including aviation and shipping, alongside an integrated analysis of feedbacks on other sectors and environmental systems. We use a global integrated assessment model to evaluate deep decarbonization scenarios for the transportation sector consistent with maintaining end-of-century warming below 1.5°C, considering varied timelines for the phase-out of fossil fuels and the implementation of advanced alternative technologies. Our most ambitious scenario eliminates transportation emissions by mid-century. We highlight the leading low-carbon technologies for each transportation mode, finding that electrification contributes most to decarbonization across the sector. Biofuels and hydrogen are particularly important for aviation and shipping, respectively. While increased emissions mitigation in the transportation sector reduces the pressure on other sectors to decarbonize, the rapid technological shifts have implications for resource demands and fuel availability.
Design of Area-speed Efficient Anurupyena Vedic Multiplier for Deep Learning Applications
Authors: M KALAISELVI C , S Sabeenian R
Published: July 2023

Hardware such as multipliers and dividers is necessary for all electronic systems. This paper explores Vedic mathematics techniques for high-speed and low-area multiplication. In the study of multiplication algorithms, various bits-width ranges of the Anurupyena sutra are used. Parallelism is employed to address challenging problems in recent studies. Various designs have been developed for the FPGA implementation employing VLSI design approaches and parallel computing technology. Signal processing, machine learning, and reconfigurable computing research should be closely monitored as artificial intelligence develops. To enable deep learning algorithms, continued research should be done on energy-constrained computing technology. Multipliers and adders are key components of deep learning algorithms. The multiplier is an energy-intensive component of signal processing in ALU, Convolutional Neural Networks (CNN), and Deep Neural Networks (DNN). For the DNN, this method introduces the Booth multiplier blocks and the carry-save multiplier in the Anurupyena architecture. Traditional multiplication methods like the array multiplier, Wallace multiplier, and Booth multiplier are contrasted with the Vedic mathematics algorithms. On a specific hardware platform, Vedic algorithms perform faster, use less power, and take up less space. Implementations were carried out using Verilog HDL and Xilinx Vivado 2019.1 on Kintex-7. The area and propagation delay were reduced compared to other multiplier architectures.
Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland
Authors: Zhang Hongquan , Wang Zhenbin , Zhang Lei , Song Jiagui , Chen Ceshi , Zhan Jun
Published: July 2023

Myoepithelium plays an important role in mammary gland development, but less is known about the molecular mechanism underlying how myoepithelium controls acinus differentiation during gestation. Herein, we found that loss of Kindlin-2 in myoepithelial cells impaired mammary morphogenesis, alveologenesis, and lactation. Using five genetically modified mouse lines combined with single-cell RNA sequencing, we found a Kindlin-2–Stat3–Dll1 signaling cascade in myoepithelial cells that inactivates Notch signaling in luminal cells and consequently drives luminal progenitor commitment to alveolar cells identity. Single-cell profiling revealed that Kindlin-2 loss significantly reduces the proportion of matured alveolar cells. Mechanistically, Kindlin-2 depletion in myoepithelial cells promotes Stat3 activation and upregulates Dll1, which activates the Notch pathway in luminal cells and inhibits luminal progenitor differentiation and maturation during gestation. Inhibition of Notch1 with tangeretin allowed luminal progenitors to regain commitment ability in the pregnant mice with Kindlin-2 depletion in myoepithelium. Taken together, we demonstrated that Kindlin-2 is essential to myoepithelium-controlled luminal progenitors to alveoli transition during gestation.
Prophylactic supplement with melatonin prevented the brain injury after cardiac arrest in rats through SIRT3/CypD activation and PINK1/Parkin induced mitophagy
Authors: Hu Yanan , Zhao Xuyan , Jiang Ge , Jin Mingxin , Jiang Wei , Han Fei
Published: July 2023

Background Prophylactic pharmacotherapy for health care in patients with high risk of cardiac arrest (CA) is an elusive and less explored strategy. Melatonin has possibilities used as a daily nutraceutical to trigger the cellular adaptation. We sought to find the effects of long-term daily prophylactic supplement with melatonin on the victim of CA. Methods Rats were divided into sham, CA, and melatonin + CA (Mel + CA) groups. The rats in the Mel + CA group received daily IP injection of melatonin 100 mg/kg for 14 days. CA was induced by 8 mins asphyxia and followed by manual CPR. The endpoint was 24 h after resuscitation. Survival, neurological outcome, and hippocampal mitochondrial integrity, dynamics and function were assessed. Results Survival was significantly higher in the Mel + CA group than the CA group (81% vs. 42%,P = 0.04). Compared to the CA group, neurological damage in the CA1 region and the expression of cytochrome c, cleaved caspase-3 and caspase-9 in the Mel + CA group were decreased (P < 0.05). Mitochondrial function and integrity were protected in the Mel + CA group compared to the CA group, according to the results of mitochondrial swelling, ΔΨm, ROS production, oxygen consumption rate, and respiratory control rate (P < 0.05). Melatonin increased SIRT3 and downregulated acetylated CypD. The mitochondrial dynamics and autophagy were improved in the Mel + CA group (P < 0.05). Conclusions Long-term daily prophylactic supplement with melatonin buy the time from brain injury after CA.