bluuebunny/crossref_metadata_2025 huggingface dataset:
Kecenderungan Spasial Fasilitas Perkotaan terhadap Sebaran Covid-19 di Kota Surakarta
Authors: Putripraja Diva Primadani , Miladan Nur , Yudana Galing
Published: June 2024

Penyebaran Covid-19 selalu dikaitkan dengan orang yang menjadi pembawa virus,sepertikasus konfirmasi tanpa gejala (asimtomatik), kasus suspek, kontak erat, dan juga yang positif Covid-19. Namun, banyak yang tidak menyadari bahwa pemerintah telah melakukan intervensi terhadap pola ruang, seperti Pemberlakukan Pembatasan Kegiatan Masyarakat (PPKM) serta pembatasan akses pada aktivitas publik lain.Berdasarkan data yang dikeluarkan oleh Pemerintah Provinsi Jawa Tengah pada Maret tahun 2022, terdapattiga daerah yang memiliki penyebaran virus tertinggi di provinsi Jawa Tengah, salah satunya adalah Kota Surakarta yang sampai tanggal 25 Maret 2022 terdapat 36.369 kasus. Pembatasan sosial bagi masyarakat secara tidak langsung memberikan pengaruh terhadap penggunaan fasilitas perkotaan di Kota Surakarta dari perspektif kecenderungan spasial. Tujuan penelitian ini adalah untuk mengetahui kecenderungan spasial fasilitas perkotaan terhadap sebaran Covid-19 di Kota Surakarta. Penelitian dilakukan menggunakan teknik analisis pemetaan spasial dengan Sistem Informasi Geografis (SIG). Hasil penelitian ini mengungkapkan bahwa mayoritas tingkat sebaran Covid-19 berada di zona kawasan sangat tinggi dan tinggi terkonsentrasi di wilayah timur Kota Surakarta yaitu Kelurahan Mojosongo dan Kelurahan Jebres yang terletak di Kecamatan Jebres. Di sisi lain, kecenderungan spasial fasilitas perkotaan yang dikunjungi oleh penyintas Covid-19 berada di zona kawasan rendah dan sangat rendah. Dengan demikian dapat dikatakan bahwa kecenderungan spasial fasilitas perkotaan yang dikunjungi oleh penyintas Covid-19 tidak berada di dalam kelurahan yang berada di zona kawasan sebaran Covid-19 sangat tinggi sehingga kecenderungan fasilitas perkotaan terhadap sebaran Covid-19 di Kota Surakarta tidaklah memiliki hubungan yang erat. Orientasi tujuan kunjungan yang dilakukan oleh penyintas Covid-19 ke fasilitas perkotaan di Kota Surakarta mayoritas adalah ke fasilitas jenis pasar dengan jumlah penyintas Covid-19 sebanyak 179 penyintas dan tersebar di seluruh kelurahan di Kota Surakarta.
Pengaruh Ketersediaan Sarana Prasarana Teknologi Sekolah Terhadap Motivasi Belajar Siswa Kelas X Jurusan TJKT di SMK Negeri 1 Sukoharjo
Authors: Pawitra Puruhita Mega , Budiyanto Cucuk Wawan , Raharjo Joko Slamet
Published: June 2024

This study examines the influence of the availability of technology facilities and infrastructure on the learning motivation of 10th-grade TJKT students at SMK N 1 Sukoharjo. Using a mixed- methods approach, quantitative data were collected through questionnaires distributed to 60 students, while qualitative data were gathered through observations during PPL activities. The results indicate that the availability of adequate computer devices, software, and laboratories significantly supports the learning process and enhances students' creativity and motivation. Observations revealed that students were more enthusiastic and actively engaged in learning with the use of technology. However, some challenges were identified, such as insufficient number of devices and the need for improved internet stability. These findings suggest that increasing the quantity and quality of technological devices and improving internet stability are crucial for creating a more conducive learning environment, thereby enhancing students' motivation and learning outcomes. Practical recommendations include that policymakers in the education sector should continue to invest in up-to-date technological facilities and infrastructure and ensure equal access for all students.
Entrepreneurial Interest and Career Development of Vocational High School Graduates Fashion Design in the Digital Era
Authors: Vitariyanti Diyan , Cahyono Budi Tri , Pambudi Nugroho Agung , Efendi Agus
Published: June 2024

Fashion design skills can be developed through classroom training and during industry placements. In the era of Industry 4.0, the focus on human capital underscores their readiness, skills, investment (especially in human resources), and proficiency in digital services. The aim study is to identification the interest and career development of SMK Tata Busana graduates in the digital era. This research uses qualitative research approach. Collect data is including interviews, observations, examination of documents or archives, and conducting tests. A triangulation method is applied, which relies on references. The result is The interests entrepreneurship and career development of SMK Fashion students in this digital era can be directed Fashion entrepreneurship among vocational school students Fashion Design usually shows a tendency to increase activity, creativity, and innovation. The career interests of SMK Fashion students that can be developed in this digital era include their capacity to use digital technology effectively, understand the functions of various applications, understand the principles of digital security, and solve technical problems that may arise. SMK as an educational institution plays an important role in honing students' abilities in digital services by providing training programs that are in line with the demands of the digital era job market.
Aziz Mahmud Hüdâyî’ye Atfedilen Bir Risâle Hulâsa-i İʿtikâdât ve Fırak Bölümü
Authors: Tarik Ramazan , Durmuş Ali
Published: June 2024

Hz. Peygamber’in vefatından sonra müslümanlar arasında cereyan eden bazı siyasî-itikadî meseleler, İslâm ümmetinin hızlı bir şekilde mezhepleşmesini tetiklemiştir. Bu mezheplerin itikadî görüşleri ve birbirleriyle olan ilişkileri ise ilk dönemlerden itibaren müelliflerin ilgi alanına girmiş ve bu fırkalara dair çeşitli eserler kaleme almışlardır. Söz konusu müelliflerin önemli bir kısmı ait oldukları mezhebin itikadî kabullerini temellendirme ve yayma amacı gütmüşlerdir, diğer fırkaların görüşlerini ise reddetme amacı gütmüşlerdir. Böylece ilk dönemlerden itibaren fırak edebiyatına dair temel klasikler kaleme alınmaya başlamış ve İslâm Mezhepleri Tarihi ilminin temelleri atılmıştır. Böylece fırak yazıcılığı nesilden nesile aktarılagelerek Osmanlı dönemine dek uzanmıştır. Çalışmamıza konu olan ve Osmanlı Devleti’nde kaleme alınan Hulâsa-i iʿtikâdât adlı eser de bu çalışmalardan biridir. Bir nüshası İstanbul Büyükşehir Belediyesi Atatürk Kitaplığında yer alan bu eserin kısmen fırak edebiyatına dair bir tür olması hasebiyle dikkat çekmektedir. Dolayısıyla bu çalışmada, asırlarca tozlu kütüphane raflarında keşfedilmeyi ve çalışılmayı bekleyen söz konusu eserin müellifi, konusu, muhtevası, amacı, özellikle de içerisinde yer alan fırkaların taksimi ve tasnif metodolojisinin araştırılarak ortaya konulması hedeflenmiştir. Ayrıca söz konusu eserin fırak kısmının transkript edilerek sahada çalışmalar yapan araştırmacıların ilgisine sunulması hedeflenmiştir.
Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 22 по 28 июня 2024 г.
Authors: Дмитриева Людмила , Чумачкова Елена , Краснов Ярослав , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: June 2024

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 Omicron вызывающих интерес (VOI) и находящихся под наблюдением (VUM), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 22 по 28 июня 2024 г
Sunlight surveillance: improved monitoring of harmful UV radiation in freshwater ecosystems
Authors: Hird Coen , Cramp Rebecca L. , Franklin Craig E.
Published: June 2024

1) Ultraviolet radiation (UVR) has a range of strong effects on freshwater ecosystems, and changing UVR is implicated in global amphibian declines. The link between UVR and amphibian declines is not well understood, largely due to limited understanding of actual UVR exposure regimes in freshwater ecosystems. Logistical challenges in measuring aquatic UVR regimes in situ have impeded progress, including the design of cost-effective radiometric monitoring tools and the measurement of UVR at ecologically relevant scales. 2) We designed novel underwater UVR loggers and deployed them in southeast Queensland creeks to log near-continuous underwater UV Index (UVI) for 11 days across 4 sampling events within the peak amphibian breeding season. We compared these data with solar modelling, dosimetric and handheld radiometric techniques. 3) The dataset (2616 hours from 39 UV sensors) revealed a highly heterogenous daily UVR microenvironment that showed capacity for harmful UVI exposures at both sites. Traditional UVR monitoring techniques often missed these high UVR exposures. 4) Fine scale UVR data logging was proven to be a gold standard of monitoring the UVR microenvironment in freshwater systems. This is important for understanding the relevance of laboratory-based studies investigating how freshwater organisms respond to UVR, monitoring changing UVR in aquatic systems and ultimately predicting how aquatic systems will respond to changes in UVR levels associated with global climate change.
The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation:A study using up-and-down sequential allocation method
Authors: Jin Lin , Li Hua , Chen Xiao-ping , Sun Li-hong , Zhang Yu , Cheng Xin-zhong , Wang Jin-zhong , Qian Xiao-wei
Published: June 2024

Background
Ciprofol(HSK3486) is a novel 2,6-disubstituted phenol derivate, a short-acting intravenous sedative, which has similar efficacy characteristics as propofol with less incidence of side effect. Both ciprofol and propofol are often used in outpatient hysteroscopic surgery for sedation. However, the relative potency of these two drugs has not been fully determined in this context.
Methods
The effective dose in 50% of subjects(ED50) value for ciprofol and propofol were calculated by Up-and-Down Sequential Allocation Method. A total of 60 parturients undergoing daytime hysteroscopy were randomly divided into two groups, which were intravenously injected with ciprofol at an initial dose of 0.4mg/kg (group C) or propofol at an initial dose of 2mg/kg (group P) at 2 min after intravenous injection of sufentanil 0.15ug/kg. A successful response is defined as the absence of patient movement in the case of cervical dilation. Conversely, the presence of patient movement is defined as failure. After successful or failed responses, each follow-up patient in the corresponding group was reduced or increased with propofol 0.5mg/kg or ciprofol 0.1mg/kg, respectively.
Results
The estimated ED50 value for ciprofol and propofol in restraining reaction of hysteroscopy dilatation was 0.444 mg/kg (95% CI, 0.385-0.503mg/kg) and 1.985 mg/kg (95% CI, 1.801–2.170 mg/kg), respectively. The incidence of respiratory depression, hypoxemia and injection pain in ciprofol was significantly lower than those in propofol(P < 0.05).
Conclusion
The ED50 of ciprofol and propofol in preventing hysteroscopy dilatation reaction was 0.444 mg/kg (95% CI, 0.385-0.503mg/kg) and1.985 mg/kg (95% CI, 1.801–2.170 mg/kg) for outpatient hysteroscopy. The potency-ratio of ciprofol and propofol observed in our study was 1.0:4.5(95%CI,1:3.9-1:5.1).
Trial registration
The study was approved by the Ethical Committee of Women’s Hospital, Zhejiang University School of Medicine (Hangzhou, China) (No. IRB-20220157-R) and was registered at the Chinese Clinical Trials.gov (NO. ChiCTR2200065954) before patient enrollment. All participants signed an informed consent form.
Trial registration
The study was registered at Chinese Clinical Trial Registry http://www.chictr.org.cn/ (Registration date:19/11/22; Trial ID: ChiCTR2200065954).
Correlation Of E-cadherin, Vimentin, CD206, PD-1, PD-L1 Expression With Clinicopathological Factors And Prognosis In Oral Squamous Cell Carcinoma
Authors: Lai Zheng-yi , Ma JIE , Yin Jia-yi , Zhu Xiu-an , Xu Qing , Zhou Jing-ping , Tao De-tao
Published: June 2024

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck. The current treatment principle is based on radical surgery, supplemented by radiotherapy and chemotherapy. However, the 5-year survival rate of patients is still around 50%. Therefore, further research on the molecular mechanism of OSCC development is needed to find out more effective treatment methods. In this study, the expression of E-cadherin, vimentin, CD206, PD-1 and PD-L1 in pathological sections of 45 patients with oral squamous cell carcinoma was quantified by immunohistochemistry. The results showed that the expression levels of vimentin, CD206 and PD-L1 were all significantly different from overall survival. At the same time, COX multivariate analysis showed that CD206, the marker of M2 macrophages,was an independent risk factor for poor prognosis in OSCC. Moreover, correlation analysis showed that the expression of E-cadherin was negatively correlated with the expression levels of vimentin, CD206 and PD-L1. The expression of vimentin was positively correlated with PD-1 and PD-L1. Therefore, the statistical data of immunohistochemical experiments in this study first showed that M2 macrophage was an independent risk factor for poor prognosis in OSCC, and was also closely related to poor overall survival. Second, it may affect the occurrence and development of OSCC tumors by inducing the occurrence of EMT in OSCC tumor cells. Third, PD-L1 has an adverse effect on the prognosis of OSCC, and it is significantly correlated with the expression levels of CD206, E-cad and vimentin. However, whether the PD-1/PD-L1 pathway can affect the occurrence and development of OSCC through M2 macrophages still needs to be further studied.
The effects of Thymus capitatus essential oil topical application on milk quality: a systems biology approach
Authors: Nehme Ralph , Gini Chiara , Vanbergue Elise , Even Sergine , Biscarini Filippo , Andrés Sonia , Rault Lucie , Noel Faustine , Hardit Valerie , Bouhallab Said , Pereira David , Ksouri Riadh , Roussel Philippe , López Secundino , Cremonesi Paola , Castiglioni Bianca , Caruso Donatella , Faré Fiorenza , Fontana Manuela , Ceciliani Fabrizio , Abdennebi-Najar Latifa
Published: June 2024

Essential oils (EO) are known for their antibacterial and anti-inflammatory properties and can be used as an alternative to reduce the reliance on antimicrobials in dairy cattle. While many studies have explored the beneficial properties of EO in vitro, their effects on milk quality and milk microbiota, when applied directly to the udder skin, remain relatively unknown. This study aimed to investigate the impact of Thymus capitatus EO (TCEO) on milk microbiota, lipidomic profile and inflammatory biomarkers in dairy cows at the end of the lactation period and udder skin microbiota. Sixteen quarters from 12 Holstein cows were selected, and TCEO was topically applied to the udder skin twice a day for seven days. Milk was collected aseptically at days 0, 7, 21, and 28 before morning farm milking. The results showed no significant changes in microbiota composition after the EO treatment. TCEO had a limited impact on the milk lipidome, primarily affecting diacylglycerol components at T21. The treatment did not affect inflammatory biomarkers, milk sensory properties, and quality. Our study demonstrates that applying 10% TCEO on cow's quarters does not significantly alter milk quality or microbiota composition in milk and skin, suggesting its safe use in dairy cows.
Association of dietary intake of theobromine with periodontitis: NHANES 2009-2014
Authors: Zhou Ya-Shi , Cai Song , Li Si-Yu , Song Ju-Kun , Peng Ju-Xiang
Published: June 2024

Background:
Theobromine intake usually comes from coffee, tea, and cocoa foods. Related studies have shown that theobromine is a bioactive molecule with anti-inflammatory, antithrombotic, anti-fat, and other effects. Periodontitis is a kind of oral inflammatory disease with high incidence, which is characterized by alveolar bone resorption leading to tooth loosening and loss. Therefore, this study aims to investigate whether theobromine intake correlates with periodontitis and whether it is a risk or protective factor for periodontitis. It hopes to provide a basis for theobromine-related diet or drugs to prevent and treat periodontitis.
Methods:
The study was based on National Health and Nutrition Examination Survey (NHANES) data from 2009–2014. The exposure factor was theobromine, derived from two-day, 24-hour total nutrient intake data from the NHANES dietary data. Periodontitis as an outcome factor was derived from the oral health component of the examination data. We used weighted multiple logistic regression, stratified analysis, and curve fitting to explore the relationship between theobromine dietary intake and periodontitis severity based on weighting and adjusting for confounding factors.
Results:
After adjusting for relevant confounding factors, weighted logistic regression showed that moderate and high levels of theobromine intake were negatively correlated with periodontitis severity (P < 0.05, OR < 1). Stratified analysis showed that race, BMI, age, diabetes, smoking, family PIR, education, and marital status had an impact on the relationship between theobromine intake and periodontitis.
Conclusion:
This study demonstrated a negative correlation between theobromine dietary intake and periodontitis, suggesting that theobromine intake may serve as a protective factor against the development of periodontitis.
Ventricular Fibrillation Occurring in the Setting of Simultaneous Type 1 Myocardial Infarction and Stress Cardiomyopathy
Authors: Youssef Salma , Deif Bishoy
Published: June 2024

Background: Simultaneous acute coronary syndrome and stress cardiomyopathy (SCM) are a rare occurrence. Here we describe the first case that we know of where aborted sudden death further complicates the presentation and management.
Case presentation: A 69-year-old male presents with ventricular fibrillation (VF) in the setting of acute coronary syndrome (ACS) and stress cardiomyopathy (SCM). Simultaneous ACS and SCM are unusual, and the sequence of events culminating in VF is unclear. Moreover, the concomitant presence of these entities confounds the decision to implant a defibrillator.
Conclusions: The case highlights the challenges of making a decision with respect to an ICD given the uncertainty associated with ventricular arrhythmia recurrence. Our case discusses the variables that factored into our decision making for a defibrillator implant and this can assist clinicians in building a framework to approach similar dilemmas. Here we review the literature to understand the risk of ventricular arrhythmia in stress cardiomyopathy and the utility of cardiac MRI in further risk stratifying this population.
Effect of ethylenediaminetetraacetic, etidronic, and peracetic acids with different concentrations on the removal of Enterococcus faecalis biofilms from root canal walls: an in vitro study
Authors: Zeyrek Salev , Ulusoy Özgür İlke , Akça Gülçin , Savur İlke Gaye
Published: June 2024

Background
To evaluate the effects of 17% ethylenediaminetetraacetic acid (EDTA), 9% and 18% etidronic acid (HEBP), and 1% and 2% peracetic acid (PAA) used alone or in combination with NaOCl on Enterococcus faecalis biofilms by using laser scanning confocal microscope.
Methods
E. faecalis biofilms were experimentally developed on the dentine discs obtained from one hundred and fifteen teeth. Infected dentine discs were randomly divided into 11 experimental (n = 10) and one control group (n = 5) according to the irrigation regimen. The percentage of dead cells in the infected samples after exposure to the different irrigation solutions was measured using a confocal laser scanning microscope. The data was statistically analyzed using the Saphiro-Wilk test and Tukey multiple comparison test with one-way ANOVA. A p-value less than 0.05 was considered to be statistically significant.
Results
The percentage of dead bacterial cells in the samples irrigated using 17% EDTA and saline was significantly lower compared to the samples irrigated with other irrigation regimens (p < 0.001). The percentage of dead bacteria observed in the samples irrigated using 9% HEBP and 18% HEBP solutions alone is lower compared to the samples irrigated using HEBP in combination with NaOCl (p < 0.001). There was no statistically significant difference between the two concentrations of peracetic acid (1–2%) and etidronic acid (9–18%) regarding biofilm elimination when these chelators were used alone or in combination with NaOCl (p > 0.001). The use of 2% peracetic acid alone in the experimentally infected samples resulted in more biofilm elimination than the use of 9% and 18% HEBP alone (p < 0.001).
Conclusion
The antimicrobial capacity of 1–2% peracetic acid is similar to its associated use with 2.5% NaOCl regarding eliminating E.faecalis biofilms from root canal walls. Therefore, irrigation of infected root canals with a single use of PAA can achieve an adequate antibacterial effect. Lower concentrations of peracetic acid and etidronic acid can be recommended to remove the E.faecalis biofilms from root canals to decrease the irrigation solutions' potential harmful effects.
Rare disease publishing trends worldwide and in China: a citespace-based bibliometric study
Authors: Kong Qi , Fan Chen-Xin , Chen Li-Ming , Zhang Ying , Yan Xin-Lei , Kang Qi , Yin Pei-Hao
Published: June 2024

Objective
Here, we analyzed the research status of rare diseases in China and globally over the past decade using bibliometric and scientific knowledge graph methods. We aimed to understand research trends, determine frontier topics, and explore the developments in and the differences between research conducted in China and the rest of the world.
Methods
We focused on rare disease literature indexed in the Web of Science and CNKI databases from January 2013 to December 2023. We selected studies based on inclusion and exclusion criteria. Bibliometric methods and the CiteSpace 6.1.R6 software were used to prepare knowledge graphs and perform comparative analyses of authors, institutions, content, and hot topics between Chinese and English databases.
Results
A total of 10,754 articles from the Web of Science database and 969 articles from the CNKI database met the inclusion criteria. In the past 10 years, the diagnosis and treatment of rare diseases have been a common research focus in both China and foreign countries. However, China has emphasized more on "orphan drugs," whereas foreign countries have focused more on "genes" and "management." The United States had the greatest number of publications. However, China ranks high in terms of publication volume and institutional ranking.
Conclusion
The research interest in rare diseases has gradually increased worldwide, with European and American countries maintaining a leading position. China has made significant contributions to rare disease research. However, its research focus is lagging compared to international trends, and a lack of collaboration with foreign countries exists. The diagnosis and treatment of rare diseases remain central themes in the field, whereas genetic research, artificial intelligence intervention, and sociological studies on rare disease populations are emerging as hot topics.
Wogonin Suppresses Proliferation, Invasion and Migration in Gastric Cancer cells via Targeting the JAK-STAT3 Pathway
Authors: Song Yang , zhao Hui , Yu Runze , Zhang Yang , Zou Yongxin , Liu Xiaofei , Sun Shuna
Published: June 2024

Wogonin is a compound extracted from the medicinal plant Scutellaria baicalensis Geogi and has been found to exert antitumor activities in a variety of malignancies. However, the molecular mechanisms involved in the anti-gastric cancer (GC) effects of wogonin remain poorly understood. In the present study, we found that wogonin treatment inhibited the proliferation of GC cells, induced apoptosis and G0/G1 cell arrest, and suppressed the migration and invasion of SGC-7901 and BGC-823 cells in vitro. In addition, wogonin inhibited in vivo tumor growth in SGC-7901 xenograft mice. Transcriptomic analysis suggested that wogonin affected several signaling pathways closely related to tumor proliferation and metastasis, including the STAT3 signaling pathway. Further research indicated that wogonin may exert antitumor effects in GC cells by downregulating the JAK-STAT3 pathway. Altogether, our results demonstrate that wogonin exerts antitumor effects by perturbing JAK-STAT3 signaling in GC cells and that wogonin may be a potential therapeutic option for GC.
Pain intensity and Disability of chronic low back pain patients receiving physiotherapy in Cameroon: A call for patients’ awareness to focus on physiotherapy treatment
Authors: Ghassi Hyacinte Trésor , Buh Franklin Chu , Muntessu Dilane Landry Nsangou , Siewe Julio Rostan , Noumoe David Léonel , Epee Paule-Laure Soppo , Douryang Maurice
Published: June 2024

Background
Chronic low back pain (CLBP) is one of the major causes of disability in the world especially in resource limited countries like Cameroon. To date, little or no studies in Central Africa have addressed the effects of conventional physiotherapy (CPT) treatment on CLBP as well as its combination with oral or topic traditional medicines (TM). This study aimed at evaluating the effects of CPT in pain and disability related to CLBP, and to find out if any additional effects of additional non-conventional TM with physiotherapy.
Methods
We conducted a cross sectional survey from October 2022 to April 2023 in some major physiotherapy units in Cameroon. Were included patients following physiotherapy treatment for CLBP. We used a structured questionnaire to collect general characteristics of participants; the level of pain was assessed with the VAS (Visual Analog Scale) and the impairment of physical function with the EIFEL scale (Echelle d’Incapacité Fonctionelle du Patient Lombalgique). The data collected were analyzed using SPSS. The paired Student test was used to compare the initial and final VAS and EIFEL scores. The Leverne test was used to compare treatment outcomes between patients who received CPT alone and those who received non-conventional TM. Statistical significance was calculated at P˂ 0.05.
Results
Were included in this study 158 patients with CLBP with a mean age of 46.3 [SD: 14.3]. Female were more represented (106/157, 67%). The patients underwent CPT for a mean duration of 8.9 months [SD: 15.8] at a weekly mean session frequency of 3.8, [SD:1]. Of the 158 participants, 35 (22.2%) underwent additional TM. Conventional physiotherapy significantly reduced pain (Initial VAS:7.4 [SD: 1.3]; Final VAS: 3.9 [SD: 1]; P = 0.000) and physical impairment of participants (Initial EIFEL: 15.7 [SD: 4.5]; Finale EIFEL: 6.8 [SD: 3.2]; P = 0.000). The study found no significative difference in pain (P = 0.317) and physical impairment (P = 0.302) in patients following exclusively CPT and those following physiotherapy additionally to non-conventional TM.
Conclusion
Physiotherapy treatment reduces pain and improve physical function of patients with chronic low back pain and additional non-conventional traditional treatment did not have improve further pain and disability in these patients.
Optimism as a predictor of poor comoliance with urate-lowering therapy in patients with gout: a prospective study
Authors: Zhao Wenkai , Zheng Chun , Huang Zhixiang , Huang Yukai , Huang Qidang , Chen Shuyang , Liu Yuqi , Li Tianwang
Published: June 2024

Background
Gout is an inflammatory disease that can cause pain and damage to joints and organs. Compliance with urate-lowering therapy (ULT) in patients with gout is poor worldwide, and few studies have focused on the association between psychology and compliance. Psychological dysfunction (such as anxiety and depression) is common in patients with gout and is correlated with health-related quality of life. This study aimed to investigate the psychological status related to poor compliance in gout patients.
Methods
A total of 530 patients with gout, 174 with ankylosing spondylitis (AS), 60 with rheumatoid arthritis (RA), and 324 healthy volunteers were included. Compliance with ULT was investigated using the medication possession ratio (MPR) over 3 months. The Life Orientation Test-Revised (LOT-R) was used to assess optimism in patients with gout and controls. The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to evaluate the severity of anxiety and depression. First, we compared the psychological status between gout patients and controls. Therefore, Spearman rank correlation analysis was used to determine the relationships between psychological and clinical variables. Finally, binary logistic regression analyses were used to analyze the predictors of poor compliance in patients with gout.
Results
The LOT-R scores of patients with gout were higher than those of patients with AS and RA (p < 0.05), while the SAS and SDS scores of patients with gout were lower than those of patients with AS and RA (p < 0.05). Among 530 patients with gout, 55.1% had an MPR < 0.8, and the MPR was negatively correlated with the LOT-R score (p < 0.05). Insufficient education, living in the countryside, having a high SUA concentration, and having a high LOT-R score predicted poor compliance with ULT (p < 0.05).
Conclusions
Gout patients share a similar optimistic status with healthy controls but are more optimistic than AS and RA patients. However, optimistic gout patients were more likely to have poorer compliance.
Trial registration:
Not applicable.
Laser solid-phase synthesis of graphene shell-encapsulated high-entropy alloy nanoparticles
Authors: Liu Zhu , Liu Yuxiang , Yuan Jianghuai , Zhou Jiantao , Pan Kewen , Zhang Ran , Zhao Rongxia , Li Lin , Huang Yihe
Published: June 2024

Rapid synthesis of high-entropy alloy nanoparticles (HEA NPs) offers new opportunities to develop functional materials in widespread applications. Although some methods have successfully produced HEA NPs, these methods generally require rigorous conditions such as high pressure, high temperature, restricted atmosphere and limited substrates, which impede practical viability. In this work, we report a laser solid-phase synthesis of CrMnFeCoNi nanoparticles by laser irradiation of mixed metal precursors on a laser-induced graphene (LIG) support with a 3D porous structure. The CrMnFeCoNi nanoparticles are embraced by several graphene layers, forming graphene shell-encapsulated HEA nanoparticles. We provide an in-depth understanding of the laser solid-phase synthesis of HEA NPs on LIG supports by simulation and experimental observations, in consideration of mixed metal precursor adsorption, thermal decomposition, reduction through electrons from laser-induced thermionic emission, and liquid beads splitting. The production rate reaches up to 30 g/h under the current laser setup. The laser-synthesized graphene shell-encapsulated CrMnFeCoNi NPs loaded on LIG supports are used directly as 3D binder-free integrated electrodes and exhibited excellent electrocatalytic activity towards oxygen evolution reaction with an overpotential of 293 mV at the current density of 10 mA/cm2 and exceptional stability over 428 hours in alkaline media, outperforming the commercial RuO2 catalyst and the counterpart catalysts reported by other methods. This work also demonstrates the versatility of this technique through the successful synthesis of CrMnFeCoNi oxide, sulfide and phosphide nanoparticles.
An immersed finite element approach based on dimensional reduction for elliptic interface eigenvalue problems with radial stratified media
Authors: Wang Wei , An Jing
Published: June 2024

In this paper, a novel and efficient immersed finite element approach based on dimensionalreduction is proposed and studied for elliptic interface eigenvalue problems with radialstratified media. Firstly, the original problem is decomposed into a series of decoupled one-dimensional second-order interface eigenvalue problems by introducing appropriate coordinate transformations. Subsequently, a class of weighted Sobolev spaces and their approximation spaces are defined in accordance with the boundary conditions and interface jump conditions, based on which, the variational form and its discrete scheme are established for each one-dimensional second-order interface eigenvalue problem, and the error estimates for the approximation eigenvalues and eigenfunctions are theoretically proved. Finally, some numerical experiments are presented to demonstrate the stability and convergence of the algorithm.
Off-pump Aortic Arch Interruption Surgery: Anesthetic Management and Outcomes
Authors: Wu Yingliang , Wu Duozhi
Published: June 2024

The present article provides an overview of the anesthetic pr ocedure employed during off-pump aortic arch interruption surger y, a cardiovascular operation. The case study involved a 54-year-o ld male patient who was diagnosed with aortic arch interruption and who underwent an off-pump surgical intervention. Anesthesia protocol: The patient fasted and abstained before surgery. In the operating room, anesthesia induction was achieve d using midazolam, esketamine, etomidate, sufentanil, and rocuro nium. Throughout the procedure, anesthesia was maintained using propofol, remifentanil, and sevoflurane, with dosage adjustments made in accordance with the progress of the surgical interventio n. Intraoperative monitoring: Conventional monitoring included E CG, blood pressure, pulse oxygen saturation, end-tidal CO2, bispec tral index, hemodynamic monitoring, and cerebral oxygen saturati on monitoring (rSO2). The patient's mean arterial pressure (MAP) was carefully regulated within the range of 60-80 mmHg, while t he heart rate was maintained between 50-90 beats per minute t o ensure a stable circulatory state. Anesthesia outcome: The patient's vital signs remained stable, with appropriate anesthesia depth. The surgery was successfully completed, and the patient was transferred to the critical care u nit for postoperative observation and treatment. In off-pump aortic arch interruption surgery, maintaining stabl e vital signs and ensuring stable circulation are crucial anesthetic management components. The reported case demonstrated a satis factory anesthesia effect with no significant complications. This ca se highlights the importance of employing reasonable anesthesia methods and monitoring measures for safe and effective patient care.
Can radiological response after downstaging of hepatocellular carcinoma serve as a basis for subsequent treatment selection?
Authors: Gao Chen-Hao , Yu Qi-Jian , Luo Xing-Yu , Chang Kai-Wun , Wang Shuo , Cao Lin-Ping , Wu Jian , Wang Lei , Yan Mao-Lin , Wang Ji-Zhou , Zheng Shu-Sen , Yang Zhe
Published: June 2024

Background and aims: Downstaging of hepatocellular carcinoma (HCC) has prevailed as a key method to curative therapy for patients who present with unresectable HCC. However, evidence to support how to choose the subsequent treatment strategies after downstaging therapy is limited. This study aim to explore the prognostic significance of radiological response after downstaging in patients with HCC. Further elucidate the impact of liver resection (LR), liver transplantation (LT) and maintenance therapy on the prognosis of patients with partial radiological response>90% (rPR>90%) and complete radiological response (rCR) following downstaging therapy.
Method: In this study, 354 consecutive patients diagnosed with HCC and treated with downstaging between January 2018 and December 2021 were included. Subsequently, they underwent LR, LT and maintenance therapy. Radiological response was assessed by determining the average percentage of tumor areas exhibiting inactivation. Specifically, radiological response was assessed as 100% minus the percentage of the longest surviving tumor diameter to the total tumor diameter. The endpoint of our study was to compare recurrence-free survival (RFS), and overall survival (OS) among patients who underwent LT, LR or maintenance therapy after downstaging therapy.
Results: Among all 354 patients included in the study, we found there were no significant differences between the rCR and rPR>90% groups in terms of three-year RFS (78.9% and 70.0% vs. 71.4% and 63.4% P=0.16) and three-year OS (97.8% and 93.3% vs. 96.9% and 93.8% P=0.90) after LR. For patients who undergo LT treatment after downstaging therapy, the one-year and three-year RFS (100.0% and 88.9% vs. 92.7% and 85.4% P=0.71) and OS (100.0% and 88.9% vs. 97.6% and 95.1% P=0.49) in pCR group and pPR>90% group are comparable. For patients with rPR>90% and rCR after downstaging, both the LT (96.2% and 92.5% vs. 88.0% and 80.0% P=0.03)and LR groups (98.4% and 93.6% vs. 88.0% and 80.0% P<0.01) exhibited better one-year and three-year OS compared with the maintenance treatment group. Additionally, LT patients demonstrated higher one-year and three-year RFS compared with LR patients(94.3% and 84.9% vs. 74.1% and 65.7% P<0.01), although there was no significant difference between the two groups in terms of one-year and three-year OS(96.2% and 92.5% vs. 98.4% and 93.6% P=0.72).
Conclusion: Surgical treatments following rPR>90% after downstaging is necessary.Besides, patients achieving rPR>90% or higher after downstaging followed by either LR or LT can both achieve satisfactory survival expectations.
Low albumin-to-creatinine ratios are associated with poor outcomes in cancer patients
Authors: Zhao Hong , Li Xiangrui , Liu Xiaoyue , Li Shuqun , Liu Chenan , Zheng Xin , Chen Yue , Shi Jinyu , Liu Qiteng , Bu Zhaoting , Shi Hanping
Published: June 2024

Background
Previous studies have shown that the albumin-to-creatinine ratio (ACR) is associated with the prognosis of patients with liposarcoma. However, the role of ACR in other tumors is unknown. Our aim was to evaluate the relationship between ACR and the prognosis of common tumors.
Methods
We used data from the Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) between 2013 and 2022 to identify Young and middle-aged patients (< 65). Spearman method was used to determine the correlation between albumin, creatinine, ACR and age. In a model adjusted for covariates, the prognostic relationship between ACR and common tumors was investigated. Subgroup analysis was performed in different tumors. Finally carried out C indices analysis to observe the value of ACR in cancer patient outcomes.
Results
In COX regression analysis of ACR and prognosis of tumor patients, whether ACR is used as a continuous variable (per 10 unit increase) or quartile, the greater the ACR value, the better the prognosis of the study population. The same results were found for different cancer species. In the C-index analysis, the prognosis of patients evaluated by ACR and tumor stage was significantly higher than that of patients evaluated by tumor stage alone.
Conclusion
A high ACR ratio is associated with a better prognosis in patients with common tumors, and is significantly better in evaluating cancer outcomes in combination with tumor stage than in evaluating tumor stage alone.
Ultra-Wideband PIN-PD THz Emitter with >5.5 THz Bandwidth
Authors: Deumer Milan , Nellen Simon , Lauck Sebastian , Keyvaninia Shahram , Berrios Shaffi , Kieper Matti , Schell Martin , Kohlhaas Robert Bruno
Published: June 2024

We present novel PIN photodiode (PD) continuous wave (cw) terahertz (THz) emitters with an increased responsivity and reduced substrate thickness compared to the state-of-the-art. Our improved devices feature up to 4 dB higher output power below 500 GHz with maximum power of -0.53 dBm at 115 GHz and strongly reduced THz absorption of the substrate for frequencies above 3 THz. The latter enables us to measure coherent cw THz spectra with a record bandwidth of 5.5 THz, for the first time, which is 1 THz (22%) more than the state-of-the-art.
Exploring Barriers and Facilitators in Nurses' Reporting of Patient and Visitor Violence: A Cross-sectional Survey
Authors: Cai Jianzheng , Ying Yajie , Wang Haifang , Yu Weixia , Wu Sisi , Zhang Yingying , Wang Yalan
Published: June 2024

Background: Patient and visitor violence (PVV) among nurses has emerged as a critical issue, posing a significant threat to nurses’ occupational safety. The primary measures employed to understand and respond to PVV is nurses’ reporting. However, the current status of PVV reporting among nurses have proven inadequate. Therefore, it is essential to explore the barriers and facilitators in nurses' reporting of PVV.
Methods: A random sample of 3,363nurses in Jiangsu Province, China, was collected between January and July 2023. The binary logistic regression was utilized to ascertain the factors influencing the study parameters.
Results: Out of the 3,363 surveyed nurses, 1,813 (53.9%) reported experiencing PVV withinthe past year. Notably, only16.1% of these nurses proactively reported PVV incidents after encountering them. Factors that facilitatedreporting of PVV comprised being male, working in specialized hospitals, serving in departments with a high prevalence of PVV, possessing lively personalities, prior awareness of PVV, and having hospitals that actively encouraged reporting while safeguarding staff interests. Conversely, factors impeding nurses from reporting PVV included having night shifts 5-9 times per month and selectively reporting based on the severity of the violence.
Conclusion: The reporting rate of PVV among nurses was notably low. Nursing managers should consider implementingcomprehensive measures that address both the facilitating and blocking factors identified in the study. This strategic approach aims to enhance the reporting rate of PVV incidents among nurses, fostering a safer and more supportive environment within healthcare settings.
A Public Benchmark for Human Performance in FCD Detection
Authors: Walger Lennart , Schmitz Matthias H. , Bauer Tobias , Kügler David , Schuch Fabiane , Arendt Christophe , Baumgartner Tobias , Birkenheier Johannes , Borger Valeri , Endler Christoph , Grau Franziska , Immanuel Christian , Kölle Markus , Kupczyk Patrick , Lakghomi Asadeh , Mackert Sarah , Neuhaus Elisabeth , Nordsiek Julia , Odenthal Anna-Maria , Dague Karmele Olaciregui , Ostermann Laura , Pukropski Jan , Racz Attila , Ropp Klaus von der , Schmeel Frederic Carsten , Schrader Felix , Sitter Aileen , Unruh-Pinheiro Alexander , Voigt Marilia , Vychopen Martin , von Wedel Philip , von Wrede Randi , Attenberger Ulrike , Vatter Hartmut , Philipsen Alexandra , Becker Albert , Reuter Martin , Hattingen Elke , Specht-Riemenschneider Louisa , Radbruch Alexander , Surges Rainer , Rüber Theodor
Published: June 2024

This study aims to report human performance in the detection of Focal Cortical Dysplasias (FCDs), localized regions of malformed cerebral cortex, using a public dataset. Additionally, it defines a subset of this data as a representative testset to establish a baseline benchmark for the evaluation of automatic FCD detection approaches. The performance of 28 human readers was analyzed using 85 publicly available cases. Performance was measured based on the overlap between predicted regions of interest (ROIs) and ground truth lesion masks. The testset was chosen to consist of 15 subjects most predictive for human performance and 13 subjects identified by at most 3 readers. Expert readers achieved an average detection rate of 68%, compared to 45% for non-experts and 27% for laypersons. Neuroradiologists detected the highest percentage of lesions (64%), while psychiatrists detected the least (34%). Neurosurgeons had the highest ROI sensitivity (0.70), and psychiatrists had the highest ROI precision (0.78). In the testset, expert detection rate was 49%. Reporting human performance in FCD detection provides a baseline for assessing the effectiveness of automatic detection methods in a clinically relevant context. The representative testset will serve as an indicator for the clinical usefulness of computer-aided FCD detection approaches.
Perception of Exclusive Breastfeeding for Working Mothers at Royal Hospital: Qualitative Study
Authors: Al-Ajmi Najat , Al-Hadidi Aida , Al-Riyami Amina , Al-Adawi Mudhar , AlAnazy Wdad , Al-Salti Nusaiba
Published: June 2024

Background
In 2022, the rate of exclusive breastfeeding in Oman was reported at 23.2%, significantly below the WHO-recommended target of 50%. This low rate is concerning given the well-documented benefits of exclusive breastfeeding for both infants and mothers, including optimal nutrition, enhanced immune protection, and reduced risks of chronic diseases. Despite global health guidelines, many mothers in Oman face challenges in maintaining exclusive breastfeeding, particularly when returning to work, highlighting the need for focused research and intervention.
Method
This qualitative study employed face-to-face interviews with working mothers at the largest tertiary hospital in Muscat, Oman, to explore their experiences with exclusive breastfeeding practices upon returning to work.
Results
Content manifest analysis revealed seven key themes: the impact of rules and regulations on mothers' decisions, protected time for breastfeeding, shift patterns, mothers' knowledge about exclusive breastfeeding, workplace accessibility, individual characteristics of mothers, and available support.
Conclusion
The study highlights deficiencies in breastfeeding practices among working mothers and underscores the necessity for enhanced managerial support to increase exclusive breastfeeding rates among healthcare providers. Additionally, it emphasizes the need for workplace restructuring to provide private spaces for milk expression during working hours.
Parameter Study of a 5G Array Antenna at 28GHz
Authors: Lak Asma
Published: June 2024

In this paper a 5G compact antenna has been simulated, fabricated and measured which works at 28GHz. The antenna structure is according to quasi Yagi antenna. The SIW technology has been used to feed the antenna. The antenna array has been designed and simulated. The S11, E pattern, and H pattern have been simulated for single element and array antenna too. The E pattern, H pattern, and S11 have been measured for single antenna. Moreover the effects of some antenna parameters i.e. (the number of stubs, the length of director, the distance between director and driver, the length of driver, and the distance between driver and reflector) on S11 has been studied. The HFSS and CST software have been used to all simulation. Also for the array antenna the effect of changing the number of directors on S11 and antenna gain are considered.
Tyrp1 is the Mendelian Determinant of the Axolotl (Ambystoma mexicanum) Copper Mutant
Authors: Cecil Raissa F. , Strohl Lloyd , Thomas Maddie K. , Schwartz James L. , Timoshevskaya Nataliya , Smith Jeramiah J. , Voss S. Randal
Published: June 2024

Several dozen Mendelian mutants have been discovered in axolotl (Ambystoma mexicanum) populations, including several that affect pigmentation. For recessive mutants have been described in the scientific literature and genes for three of these have been identified. Here we describe and genetically dissect copper, a mutant with an albino-like phenotype known only from the pet trade. We performed a cross segregating copper and wildtype color phenotypes and used bulked segregant RNA-Seq to identify a region on chromosome 6 that was enriched for single-nucleotide polymorphisms (SNPs) between the color phenotypes. This region included Tyrosinase-like Protein 1 (Tyrp1), a melanin synthesis protein that when mutated, is associated with lighter than black melanin coloration in animal models and oculocutaneous albinism in humans. Inspection of RNA-Seq reads identified a single nucleotide deletion that is predicted to change the coding frame, introducing a premature stop codon in exon 6 and yield a truncated Tyrp1 protein in copper individuals. Using CRISPR-Cas9 editing, we show that wildtype Tyrp1 crispants exhibit copper pigmentation, thus confirming Tyrp1 as the copper locus. Our results suggest that commercial and hobbyist axolotl populations may harbor useful mutants for biological research.