bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Data S6 from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment.
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Dan , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B , Merajver Sofia Diana , Merrill Nathan
Published: June 2023

Clinicopathologic characteristics of source patients for brain metastases PDX models: Group B.
Supplementary Figure 7 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival following Immunotherapy in Murine GBM.
Authors: Nisnboym Michal , Vincze Sarah R. , Xiong Zujian , Sneiderman Chaim T. , Raphael Rebecca A. , Li Bo , Sever ReidAnn E. , Jaswal Ambika P. , Day Kathryn E. , Latoche Joseph D , Foley Lesley M , Karimi Hanieh , Hitchens T. Kevin , Agnihotri Sameer , Hu Baoli , Rajasundaram Dhivyaa , Anderson Carolyn J , Blumenthal Deborah T. , Pearce Thomas M. , Uttam Shikhar , Nedrow Jessie R. , Panigrahy Ashok , Pollack Ian F , Lieberman Frank S , Drappatz Jan , Raphael Itay , Edwards Wilson B. , Kohanbash Gary
Published: June 2023

Validation of CD69 expression on immune cells by flow cytometry.
Supplementary Data S5 from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment.
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Dan , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B , Merajver Sofia Diana , Merrill Nathan
Published: June 2023

GSEA analysis using the oncogenic, KEGG, and GOBP gene sets.
Supplementary Figure 6 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival following Immunotherapy in Murine GBM.
Authors: Nisnboym Michal , Vincze Sarah R. , Xiong Zujian , Sneiderman Chaim T. , Raphael Rebecca A. , Li Bo , Sever ReidAnn E. , Jaswal Ambika P. , Day Kathryn E. , Latoche Joseph D , Foley Lesley M , Karimi Hanieh , Hitchens T. Kevin , Agnihotri Sameer , Hu Baoli , Rajasundaram Dhivyaa , Anderson Carolyn J , Blumenthal Deborah T. , Pearce Thomas M. , Uttam Shikhar , Nedrow Jessie R. , Panigrahy Ashok , Pollack Ian F , Lieberman Frank S , Drappatz Jan , Raphael Itay , Edwards Wilson B. , Kohanbash Gary
Published: June 2023

SUV analysis and BioD data of CD69 immuno-PET.
Supplementary Data S4 from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment.
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Dan , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B , Merajver Sofia Diana , Merrill Nathan
Published: June 2023

Ipathway analysis table
Supplementary Data S3a and S3b from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment.
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Dan , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B , Merajver Sofia Diana , Merrill Nathan
Published: June 2023

Genomic comparison across the different metastatic sites compared to the matched primary. A. Genomic alterations across metastatic sites compared to matched primary B. Copy number variations across metastatic sites compared to matched primary
Supplementary Figure 4 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival following Immunotherapy in Murine GBM.
Authors: Nisnboym Michal , Vincze Sarah R. , Xiong Zujian , Sneiderman Chaim T. , Raphael Rebecca A. , Li Bo , Sever ReidAnn E. , Jaswal Ambika P. , Day Kathryn E. , Latoche Joseph D , Foley Lesley M , Karimi Hanieh , Hitchens T. Kevin , Agnihotri Sameer , Hu Baoli , Rajasundaram Dhivyaa , Anderson Carolyn J , Blumenthal Deborah T. , Pearce Thomas M. , Uttam Shikhar , Nedrow Jessie R. , Panigrahy Ashok , Pollack Ian F , Lieberman Frank S , Drappatz Jan , Raphael Itay , Edwards Wilson B. , Kohanbash Gary
Published: June 2023

Production, quality control, and immunoreactivity of 89Zr-DFO-CD69 Ab.
Supplementary Data S2 from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment.
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Dan , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B , Merajver Sofia Diana , Merrill Nathan
Published: June 2023

Molecular aberrations comparing paired primary breast cancer and brain metastases: Group A case series.
Data from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment.
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Dan , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B , Merajver Sofia Diana , Merrill Nathan
Published: June 2023

Abstract
The development of novel therapies for brain metastases is an unmet need. Brain metastases may have unique molecular features that could be explored as therapeutic targets. A better understanding of the drug sensitivity of live cells coupled to molecular analyses will lead to a rational prioritization of therapeutic candidates. We evaluated the molecular profiles of twelve breast cancer brain metastases (BCBM) and matched primary breast tumors to identify potential therapeutic targets. We established six novel patient-derived xenograft (PDX) from BCBM from patients undergoing clinically indicated surgical resection of BCBM and used the PDXs as a drug screening platform to interrogate potential molecular targets. Many of the alterations were conserved in brain metastases compared to the matched primary. We observed differential expressions in the immune-related and metabolism pathways. The PDXs from BCBM captured the potentially targetable molecular alterations in the source brain metastases tumor. The alterations in the PI3K pathway were the most predictive for drug efficacy in the PDXs. The PDXs were also treated with a panel of over 350 drugs and demonstrated high sensitivity to HDAC and proteasome inhibitors. Our study revealed significant differences between the paired BCBM and primary breast tumors with the pathways involved in metabolisms and immune functions. While molecular-targeted drug therapy based on genomic profiling of tumors is currently evaluated in clinical trials for patients with brain metastases, a functional precision medicine strategy may complement such an approach by expanding potential therapeutic options, even for BCBM without known targetable molecular alterations.
GAMBARAN KEBERHASILAN OPERASI DAN KOMPLIKASI VITREKTOMI PADA PASIEN RETINOPATI DIABETIKA PROLIFERATIF DI PUSAT MATA NASIONAL RUMAH SAKIT CICENDO BANDUNG
Authors: Muslima Patriotika , Boesoirie Shanti F
Published: June 2023

Pendahuluan : Diabetes mellitus merupakan penyakit metabolik yang dapat menyebabkan berbagai komplikasi baik makrovaskular dan mikrovaskular, termasuk retinopati diabetik sebagai penyebab utama hilangnya penglihatan yang didapat. Pasien diabetes melitus dengan komplikasi retina yang sudah lanjut sering memerlukan tindakan operasi (vitrektomi). Metode : Penelitian ini merupakan suatu penelitian retrospektif dari 148 mata yang telah dilakukan operasi vitrektomi karena komplikasi retinopati diabetik. Keberhasilan secara fungsional didefinisikan tajam penglihatan 20/200 atau lebih baik setelah evaluasi 1 bulan pasca operasi sedangkan keberhasilan anatomi didefinisikan menempelnya retina 3600 setelah evaluasi 1 bulan pasca operasi. Hasil : Jumlah total terdapat 158 mata yang dilakukan tindakan VPP akibat komplikasi dari retinopati diabetika proliferatif dan dilakukan kontrol 1 bulan pasca operasi, didapatkan 68,5% perempuan dan 31,95% laki-laki dengan usia rerata 59,11 tahun. Keberhasilan secara fungsional dan anatomis adalah 27,22% dan 98,1. Komplikasi yang paling sering terjadi adalah peningkatan tekanan intraokular (8,86%), perdarahan vitreus berulang (5,06%), katarak (2,53%), dan ablasio retina (1,9%). Simpulan : Vitrektemi dilakukan pada retinopati diabetika proliferatif dengan indikasi utama adanya perdarahan vitreus dan ablasio retina traksi. Keberhasilan operasi secara anatomi lebih baik dibandingkan dengan keberhasilan secara fungsional. Penelitian prospektif lebih lanjut diperlukan untuk mengevaluasi keberhasilan operasi secara fungsional dan anatomi dalam jangka panjang serta faktor prediksi keberhasilan operasi pada retinopati diabetika proliferatif.
Hubungan Derajat Kelainan Refraksi Dan Kejadian Astenopia Pada Mahasiswa Fakultas Kedokteran Unika Atma Jaya
Authors: Rustjo Chrestella , Kuswidyati Cisca
Published: June 2023

Pendahuluan: Kelainan refraksi merupakan kelainan mata yang umum ditemukan dan menjadi penyebab kebutaan tertinggi ketiga di Indonesia. Jenis dan derajat kelainan refraksi bervariasi di dalam populasi. Astenopia adalah kumpulan gejala kelelahan mata yang dapat disebabkan oleh berbagai hal, dimana kelainan refraksi merupakan salah satu faktor risiko terjadinya astenopia. Metode: Studicross sectional dengan total responden sebanyak 79 orang mahasiswa preklinik fakultas kedokteran Unika Atma Jaya. Pengumpulan data dilakukan menggunakan kuesioner terkait kelainan refraksi dan kejadian astenopia yang dialami responden, serta pengukuran visus dilakukan dengan menggunakan aplikasi Peek Acuity®. Analisis data dilakukan dengan uji Chi Square. Hipotesis nol ditolak apabila ?< 0.05. Hasil: Derajat kelainan refraksi pada kelompok responden didapatkan derajat ringan sebesar 31,6%; derajat sedang sebesar 58,2%; dan derajat berat sebesar 10,1%. Kejadian astenopia yang didapatkan pada kelompok responden adalah sebesar 94.9%. Tidak terdapa thubungan signifikan antara derajat kelainan refraksi dan kejadian astenopia (p = 0,709). Simpulan: Miopia disertai astigmatisme merupakan jenis kelainan refraksi yang paling banyak ditemukan di kalangan mahasiswa kedokteran preklinik. Derajat kelainan refraksi yang paling banyak adalah derajat sedang. Lebih dari setengah responden mengalami astenopia. Hubungan derajat kelainan refraksi dan kejadian astenopia tidak bermakna secara statistik. Kata Kunci: astenopia, kelainan refraksi.
Hubungan Usia dan Jenis Kelamin dengan Jenis Kelainan Refraksi pada Anak di Pusat Mata Nasional Rumah Sakit Mata Cicendo
Authors: Oktarima Primawita , Caesarya Sesy , Irfani Irawati , Kuntorini Mayasari Wahyu , Memed Feti Karfiati , Ginting Dianita Veulina
Published: June 2023

Introduction: Refractive disorder is one of the most common causes of visual impairment worldwide and becomes the second leading cause of blindness that can be cured. Uncorrected refractive error is the leading cause of vision impairment in children. An estimated 12,8 million children 5 to 15 years of age worldwide are affected. Purpose: To describe the correlation between age and sex with the refractive disorder in National Eye Center, Cicendo Eye Hospital on January – December 2015. Method: An analytical observational study. The subjects were children diagnosed with refractive disorders based on medical records at the pediatric ophthalmology and strabismus department in Cicendo Eye hospital. The data analyzed using chi-square (x2) with significances of p < 0.05. Results: We found 1684 refractive error patients; 41.9% are boys and 58.1% girls. It mainly happened in 11-15 years of age (52.9%). Simple myopia and compound myopic astigmatism are mostly found in girls aged 11-15 years old. Simple hypermetropia and simple myopic astigmatism are primarily in boys aged 6-10 years old, and compound hypermetropic astigmatism in boys 0-5 years old. Conclusion: Recognition of any refractive error in children is a major step in preventing childhood vision loss, a significant public health problem. There is a correlation between age and sex with the refractive disorder (p < 0.05). Keywords: refractive disorders, children, visual impairment.
Hubungan Antara Usia, Tekanan Intraokular, dan Komorbid Terhadap Keberhasilan Trabekulektomi pada Pasien Glaukoma Primer
Authors: Sinurat Veronica , Christin Reinne Natali
Published: June 2023

Pendahuluan : Trabekulektomi merupakan prosedur bedah filtrasi untuk meningkatkan pengeluaran aqueous humor agar terjadi penurunan tekanan intraokular (TIO) pada penderita glaukoma. Penelitian ini dilakukan untuk mengetahui apakah terdapat hubungan antara usia, TIO awal, dan komorbid terhadap keberhasilan trabekulektomi di RSU UKI Jakarta. Metode : Penelitian ini merupakan suatu penelitian retrospektif dari 35 mata yang telah dilakukan operasi trabekulektomi. Keberhasilan trabekulektomi didefinisikan sebagai complete success jika setelah operasi didapatkan TIO ? 21 mmHg tanpa obat anti glaukoma, partial success jika TIO ? 21 mmHg dengan obat anti glaukoma, dan failure jika TIO > 21 mmHg. Data yang telah terkumpul dianalisis dengan program SPSS. Hasil : Jumlah total terdapat 35 mata yang dilakukan operasi trabekulektomi dengan glaukoma primer, didapatkan 51,4% laki-laki dan 48,6% perempuan dengan usia rerata 58,3 tahun. TIO awal pasien saat datang ke poliklinik sebagian besar > 21 mmHg (82,9%) dan 20 pasien (42,9%) memiliki komorbid (hipertensi dan diabetes mellitus). Persentase trabekulektomi dengan complete success, partial success, dan failure didapatkan 34,3%, 48,6%, dan 17,1%. Penelitian ini tidak mendapatkan adanya hubungan antara usia, TIO awal, dan komorbid terhadap keberhasilan trabekulektomi (p > 0,05). Kata kunci : diabetes melitus, glaukoma, hipertensi, trabekulektomi, tekanan intraokular
Characteristics of Retinoblastoma Patients Treated with Transpupillary Thermotherapy from January – December 2020 in Cicendo National Eye Hospital
Authors: Rahayu Annisa , Ihsan Grimaldi , Iskandar Erwin , Oktarima Primawita , Kartasasmita Arief S , Virgana Rova
Published: June 2023

Introduction: Treatments for retinoblastoma were aimed to preserve the globe and saving the vision. Transpupillary thermotherapy (TTT) has been used to treat several type of small or medium sized tumor, including retinoblastoma. Purpose: To describe the TTT laser properties for retinoblastoma tumor. Methods: Retrospective method was selected from the medical records. Total sampling data were collected from the patients with diagnosis of retinoblastoma who underwent examination under anasthesia and transpupillary thermotherapy laser in Cicendo National Eye Hospital from January to December 2020. The data collected consist of the demographic information, retinoblastoma tumor characteristics, and TTT laser properties. Results: There was eleven eyes from ten patients who underwent TTT session in Cicendo National Eye Hospital from January until December 2020. Majority was male patients with mean age at diagnosis 16.3 ± 17.01 months and mean TTT session 3.54 ± 1.36 for each eye. The mean total laser that applied in every session were 169.25 ± 241.21 times, with mean power 941.35 ± 1894.16 mW, and mean time exposure 1392.89 ± 1349.09 ms. All of the patients were on chemotherapy systemic treatment, with mean frequency 12.2. Ninety percent patients showed regression of the tumor. Conclusion: Majority of the patients retinoblastoma who treated with TTT were male, bilateral tumor, with mean TTT session 3.54 for each eye. All of the patients treated with systemic chemotherapy. Majority of the eye in this study showed tumor regression.
Validation of the National Institutes of Health Stroke Scale in Intracerebral Hemorrhage
Authors: Dusenbury Wendy , Tsivgoulis Georgios , Chang Jason , Goyal Nitin , Swatzell Victoria , Alexandrov Andrei V. , Lyden Patrick , Alexandrov Anne W.
Published: June 2023

Background

We sought to determine if the National Institutes of Health Stroke Scale (NIHSS) has a greater discriminative power than Glasgow coma scale (GCS) to identify patients at risk of poor early functional outcomes and large hematoma volumes.

Methods

We prospectively collected clinical assessments, imaging, and outcome data in consecutive patients with intracerebral hemorrhage, and determined the ability of GCS and NIHSS to predict poor functional outcome (modified Rankin scale 3–6) and hematoma volume >30 cm
3
using receiver operating characteristics analysis, C‐statistics, and the DeLong test.

Results

We studied 672 patients with intracerebral hemorrhage (mean age 62±14 years; 56% men; median intracerebral hemorrhage score=1, interquartile range (IQR) 0–2; median intracerebral hemorrhage volume 7 cm
3
, IQR 2–19) with median NIHSS of 8 (IQR 3–18) and GCS 15 (IQR 7–15). NIHSS correlated strongly to GCS (r=−0.773;
P
<0.001). Admission NIHSS (C‐statistic: 0.91; 95% CI, 0.89–0.93) predicted better than GCS (0.78; 95% CI, 0.75–0.81) discharge poor functional outcome (DeLong test
P
<0.001). NIHSS (0.82; 95% CI, 0.78–0.86) also discriminated better than GCS (0.78; 95% CI, 0.73–0.83) patients with large hematoma volume (DeLong test
P
=0.029).

Conclusion

The NIHSS has a greater discriminative power than GCS to identify patients at risk of poor early functional outcomes and large hematoma volumes.
Who Were the Gods of Panamuwa I?
Authors: Dušek Jan
Published: June 2023

Panamuwa I, king of Samʾal/Yʾdy, commissioned a statue of Hadad in approximately the second quarter of the eighth century BCE. The inscription on the statue, written in the Samʾalian language, contains four lists of gods. In lines 2–3 and 18–19, these gods are Hadad, El, Rešef, Rākib-El, and Šamaš. The list in line 11, however, contains a theonym that is not attested in the other three lists; it is usually read Arqû-Rešef. A collation of the inscription yields a new reading and interpretation of the text in line 11 that sheds light not only on the identity of the enigmatic Arqû-Rešef, but also on the whole list of gods in line 11.
‘As Far as the East Is from the West, and the North Is from the South’
Authors: Cherkashina Anna
Published: June 2023

This article continues a series of studies dedicated to Syriac love magic as attested by texts found in Syriac magical codices dated to the 18th–20th century. Here I address five Syriac recipes that I consider to belong to the category of separation spells. Four of them are titled ‘For Hatred’ and are edited for the first time. Another one can be found in The Nestorians and Their Rituals and exists only in the English translation provided by G.P. Badger. Based on their supposed proto-text, the five texts can be divided into three spells. The separation spells are also compared with Syriac spells for attraction. The comparison involves the textual level as well as the magical practices for inducing hatred or love. In the third section of the article, I address the phenomenon of Syriac hate spells in a wider context by providing parallels from Jewish, Coptic, Mandaic, and Arabic magical traditions.
A Jewish Aramaic Circus Curse Tablet from Antioch
Authors: Folmer Margaretha , Elitzur-Leiman Rivka
Published: June 2023

In this contribution we publish a lead circus curse tablet written in Jewish Palestinian Aramaic (Princeton Art Museum excavation no. 3608-I57). The tablet was found in 1935 during excavations near the first turning-post at the hippodrome of Antioch on the Orontes (modern-day Antakya, Turkey). The use of Greek and Latin defixiones agonisticae (agonistic binding spells) in chariot races was a wide-spread phenomenon during the Roman Byzantine Period. Curse tablets were inscribed with aggressive incantations that aimed at the defeat of rivals in the chariot races. The tablet under discussion is a unique piece: It is the only known lead circus curse tablet that was written in a Jewish language and script. The tablet is datable to the fifth or sixth century CE.
Blue Berets, Burning Brushfires
Authors: Adebajo Adekeye
Published: June 2023

This article makes three important arguments. The first is that one of the most crucial factors in explaining the various outcomes of UN peacekeeping cases over the past seventy-five years can be found in the role of contingencies: the idiosyncratic circumstances that have combined to enable success or failure. The second is that these peacekeeping missions critically demonstrate the importance of focusing attention on the significant role of key domestic, regional, and external actors. The third is that contingencies at these three important levels, rather than any established security patterns or theories, are often the most critical factors in explaining the outcomes of UN peacekeeping missions over the past seven and a half decades. The choices of national and regional actors as well as external great powers often shape how these missions start, develop, and end. Examining interests and motivations in detail thus helps explain how and why UN peacekeeping missions have succeeded or failed.
Retaining Flexibility
Authors: Drohan Brian
Published: June 2023

Although UN peace operations began with unarmed observer missions in 1948–1949, the first armed force—the UN Emergency Force (UNEF)—was deployed in 1956 due to the Suez crisis. Scholars and practitioners have since interpreted the UN Secretariat’s 1958 study of that experience, called the Summary Study, as a foundational text in the history of UN peacekeeping because it supposedly codified the key principles of impartiality, nonuse of force, and consent. But much of the Summary Study’s origin story is inaccurate or unknown. By explaining Secretary-General Dag Hammarskjöld’s intentions for the study, as well as how those intentions changed, this article argues that far from “codifying” foundational principles, the Summary Study did the opposite: it ensured that future peacekeeping operations would continue on an ad hoc, flexible basis that permitted the Secretary-General and Member States to exercise a wide range of discretion in determining how to conduct future operations.
Pluma, a new genus of slug moths (Lepidoptera: Limacodidae) from South China, with descriptions of two new species
Authors: LIANG JIAMIN , SOLOVYEV ALEXEY V. , WANG HOUSHUAI
Published: June 2023

The genus Pluma, gen. nov. is established to accommodate two new species of limacodid moths, P. shuni sp. nov. and P. yuensis sp. nov., from South China. Based on morphological and molecular characters, the species cannot be placed in any existing genus and therefore they placed in the newly erected one. The new taxa are supported by morphological characters and DNA barcode data. Male adults, including wing venation and genitalia, are illustrated, along with a barcode-based tree.
Review of the Australian endemic genus Tasmosalpingus Lea, 1919 (Coleoptera, Cucujoidea, Tasmosalpingidae)
Authors: LIU ZHENHUA , PORCH NICHOLAS , ŚLIPIŃSKI ADAM
Published: June 2023

The sole genus of the Australian endemic family Tasmosalpingidae, Tasmosalpingus Lea, 1919, is revised and T. promiscuus Lea, 1919 is proposed as a junior synonym of T. quadrispilotus Lea, 1919. T. magnus sp. nov. is described from New South Wales and Victoria, representing the northernmost distribution of this family. A predicted distribution of the genus is given, and the relationships between Tasmosalpingidae, Cyclaxyridae and Lamingtoniidae are discussed.
Challenges in and Opportunities for International Collaboration: Costing Flood Damages and Losses across Canada, Mexico, and the United States
Authors: Adeel Zafar , Bakkensen Laura , Cabrera-Rivera Orlando , Franco Ernesto , Garfin Gregg M. , McPherson Renee A. , Méndez Karla , Wen Xin
Published: June 2023

Flooding, including inland and coastal flooding, is one of the most devastating and costly natural hazards in Canada, Mexico, and the United States. Recent research conducted by an international team has focused on understanding the true and comprehensive economic costs of floods, with an eye toward addressing their impacts, allocating adequate resources for monitoring and preparedness, and building resilient communities. Flood-costing methods vary greatly among federal and subnational jurisdictions across the three North American countries. Because the rigor and consistency of existing datasets across the three countries vary significantly, it is also difficult to determine the economic impacts of cross-border events. This paper aims to critically analyze the research methods used to conduct this trinational project and develop recommendations for enhancing impacts of such work in the future. We discuss three major research barriers: gaps in knowledge and research capacity, differences in data collation and analysis methods across the three countries, and linguistic barriers in working across disciplines and economic sectors. We also explore how the COVID-19 pandemic significantly added to these three barriers. We propose creation of new institutional mechanisms that can play a major role in developing comprehensive, consistent, and cohesive data gathering approaches in Canada, Mexico, and the United States.
Citizens’ Behavioral Acceptance of Electronic Voting Machine (EVM) in the Electoral Culture of Bangladesh
Authors: Sayem Md. Abu
Published: June 2023

Bangladesh is a democratic country that has implemented electronic voting machines (EVMs) to make elections more efficient, secure, accurate, and timely. The purpose of this study is to explore the factors that influence behavioral intentions to use EVM. The study identified four independent variables based on the literature behind citizens’ intentions to use EVM. The study followed an explanatory research approach among e-voters in Dhaka, Bangladesh. The findings reveal that performance expectancy, trust in institutions, and effort expectancy have positive associations ( p < 0.01) with behavioral intention to use EVM. In contrast, trust in technology has not been found to have any significant association ( p > 0.05).
Impact of Obstructive Sleep Apnea on Health-Related Quality of Life in Patients With Partial Laryngectomy for Laryngeal Cancer
Authors: Chen Min , Shi Fang , Wu Haitao , Cheng Lei , He Peijie , Jin Qian , Huang Jingjing
Published: June 2023

Objectives: To evaluate the possible risk factors of obstructive sleep apnea (OSA) and its impact on the health-related quality of life (HRQoL) in patients with partial laryngectomy for laryngeal cancer. Methods: A cross-sectional method was used to carry out this study. Patients who underwent partial laryngectomy for laryngeal cancer completed overnight polygraphy (PG) home sleep tests and quality of life questionnaires. The Medical Outcome Study 36-item Short-Form Health Survey (SF-36) questionnaire was used to investigate the factors influencing HRQoL. Results: A total of 59 patients completed the PG tests and quality of life questionnaires, with 74.6% demonstrating evidence of OSA. There were significant differences in tumor area and neck dissection between OSA group and non-OSA groups. Based on sleep-related parameters, patients were divided into cluster 1 (n = 14) and cluster 2 (n = 45) using principal component analysis combined with K-means clustering. Two clusters had significantly different scores of body pain, general health, and health transition in SF-36 domains. Independent factors associated with general health were identified as tobacco use (OR = 4.716), alcohol use (OR = 3.193), and OSA-related condition (OR = 11.336). Conclusions: Larger tumor area and neck dissection might be associated with an increased risk for developing OSA in patients with partial laryngectomy for laryngeal cancer. OSA partially mediated the effect on physical health, including body pain, general health, and health transition. It is important to be aware of the potential impact of OSA on diminished HRQoL of these patients.
Comparison Between Flap and Primary Closures of Persistent Tracheocutaneous Fistula: A Scoping Review
Authors: Almutairi Nasser , Alshareef Waleed , Almakoshi Latifah , Zakzouk Abdulmajeed , Aljasser Abdullah , Alammar Ahmed
Published: June 2023

Objectives: To compare the susceptibility and complication rates between flap and primary closures for tracheocutaneous fistula (TCF). Methods: We searched 4 online databases (Web of Science, Cochrane Library, PubMed, and Scopus) for relevant articles published from study inception until August 2022. Studies including at least 5 adult or child patients with persistent TCFs who underwent closure surgery via primary or flap repair were included. All included studies reported outcomes of surgical repairs such as successful closure rates and complications. In addition, we performed single-arm meta-analyses for each surgical method using the Open Meta-Analyst software to calculate the pooled event rate with a 95% confidence interval (CI); compared the 2 surgical procedures using the Review Manager software using the risk ratio with 95% CI; and assessed study quality based on the National Heart, Lung, and Blood Institute criteria. Results: Overall, 27 studies with 997 patients were included. No significant difference was observed between the closure success and major complication rates of surgical methods. The primary and flap closures had overall success rates of 0.979 and 0.98, respectively. The overall major complication rates in primary and flap closures were 0.034 and 0.021, respectively; and that of minor were 0.045 and 0.04, respectively. In primary closure, a significant decrease in the success rate with increasing age at the time of decannulation was observed. In addition, the risk of major complications increased with increasing time from decannulation to closure. Conclusions: Both the primary and flap repairs of TCF are effective based on closure success and complication rates; therefore, they are both acceptable therapeutic alternatives, and flap repair can be considered when other techniques have failed. However, further prospective randomized studies comparing these 2 procedures are needed to support our results.
Combustion of pellets produced from corn straw and cashew nut shell in residential and industrial scenarios: Chemical, thermal and emission analyses
Authors: Moreira Fabriciany Lourenço , Santos Gilvan Ribeiro dos , Araújo Rinaldo dos Santos , de Oliveira Mona Lisa Moura , Cavalcante Francisco Sales Ávila , Serra Daniel Silveira
Published: June 2023

The Brazilian Northeast region has considerable agricultural potential for corn and cashew nuts production. Residues from these cultures can be densified into pellets and used as heat generators in industries and homes. In this study, corn straw pellets (CSP) and cashew nut shells pellets (CNSP) were handmade, together with a variation using glycerol as a binder (CSGP and CNSGP). All pellets were subjected to chemical, thermal and exhaust gas analyses of their combustion. All analyses were based on two different scenarios: (i) the use of CSP and CSGP for energy supply in residential use and (ii) the use of CNSP and CNSGP for energy supply in industrial use. All pellets were subjected to chemical, thermal and exhaust gas analyses of their combustion. Chemical analysis involved the study of various fuel properties, comprehending moisture content (% U), bulk density (kg m−3), volatile materials (% V), ash content (% C) and fixed carbon (%FC), and all evaluated pellets met two or more international trading standards. The combustion process analyses in the residential scenario showed higher average temperatures and lower carbon monoxide (CO) and nitrogen oxide (NO x) concentrations obtained during CSP combustion than those of CSGP, and in the industrial scenario showed average similar temperatures and lower CO and NO x concentrations obtained during CNSP combustion than those of CNSGP. Ours results demonstrate the great potential of corn straw and cashew nut shells as crops to be integrated into the biomass supply chain for energy generation and agro-ecological development.
Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury
Authors: Guan Ruoyu , Pan Mengxue , Xu Xiaoya , Du Lixia , Rao Xinxin , Fu Guoxiang , Lv Tao , Zhang Long , Li Yuanchuang , Tang Peiyuan , Zhou Yi , Wang Yanqing , Zhang Zhen , Gao Jianjun , Zhou Hong , Mi Wenli , Hua Guoqiang
Published: June 2023

Epithelial regeneration is critical for barrier maintenance and organ function after intestinal radiation injury. Accumulating evidence indicates that the interleukin family members play critical roles in intestinal stem-cell-mediated epithelial regeneration. However, little is known about the relationship between interleukin 33 (IL-33)/ST2 axis and intestinal regeneration after radiation injury. We demonstrate here that IL-33 expression significantly increased after radiation treatment. Deficiency of IL-33/ST2 promotes intestinal epithelial regeneration, resulting in a reduction of mortality during radiation-induced intestine injury. Using ex vivo organoid cultures, we show that recombinant IL-33 promotes intestinal stem cell differentiation. Mechanistically, the effects of IL-33 were mediated by activation of transforming growth factor-β signaling. Our findings reveal a fundamental mechanism by which IL-33 is able to regulate the intestinal crypt regeneration after tissue damage.
Water Stories
Authors: Snowber Celeste Nazeli
Published: June 2023

This poetic article explores the relationship between water and ecology and how an embodied awareness and insights surface out of the practice of swimming. The connections between the inner and outer landscapes of waterways and the land are written into being as they nourish embodied resonances. Moving and writing are inextricably linked and open a syntax of poetry and prose founded in the rhythm of a swimming practice. Themes of yearning, longing, timelessness, existence, and creativity emerge out of these visceral explorations. The article integrates poetry and photographic images of the author’s swimming practice. Water stories is situated within the methodologies of embodied inquiry and poetic inquiry and supports the intersection and layers between what it means to think, move, and write in performative ways.
The ACES Guide for Researchers in Psychology: Fostering Researchers’ Informed Decision-Making about Theory Selection and Theoretical Integration
Authors: van Zomeren Martijn
Published: June 2023

Psychology is as diverse as it is divided: For many research questions asked, different and competing theories will often exist to answer them. Despite the value of diversity, this lack of theoretical common ground has resulted in major empirical fragmentation in psychological research (e.g., a “confetti factory” of empirical trivia), but also to a lack of attention within the research process itself to theory selection (i.e., which theory to use and why?) and theoretical integration (i.e., how can one “connect the dots”?). This article aims to offer practical guidance to researchers in psychology about how to make informed decisions on theory selection and theoretical integration. To this end, I outline the ACES ( Analyzing, Comparing, Evaluating, and Synthesizing) guide, which offers a process-oriented guide toward such informed decision-making. Through its four-step structure and each step’s engaging and critical lead questions, researchers actively engage in a dialog in which they systematically question and explore which theories to select (and why), and whether a synthesis of different theories is possible and appropriate. As such, the ACES guide offers a practical, theory-focused tool for researchers in psychology.
Did stopping ultrasound surveillance during COVID-19 result in an increase of the dialysis access thrombosis rate?
Authors: Allsopp Karen , Smith Lindsay
Published: June 2023

Purpose:

The COVID-19 pandemic resulted in cessation and subsequent reduction of routine care including the outpatient ultrasound surveillance of AVF. This un-planned service disruption allowed evaluation of effectiveness of US surveillance in reducing AVF/AVG thrombosis.

Methods:

This study was a secondary data analysis of monthly access patency for all in-centre patients receiving haemodialysis using an AVF or AVG over a 2-year period (April 2019-March 2021). The study included 298 patients with age, access type, patency and COVID status measured as variables. Thrombosis rates for the 12 months prior to COVID-19 and then during the first 12 months of the pandemic were also measured. Statistical analysis to assess mean and standard deviation for relevant variables was used. A p-value of <0.05 was deemed significant.

Results:

At the end of the study an increase in thrombosis rate (%) in the non-surveillance year was observed ((1.20) thrombosis/patient/year in the surveillance group vs (1.68) thrombosis/patient/year in the non-surveillance group). Monthly mean of thrombosed access during surveillance ( M = 3.58, 95% CI 2.19–4.98, SD = 2.193) and non-surveillance ( M = 4.92, 95% CI 3.52–6.31, SD = 2.19); t(7148) = 2.051, p = 0.038.

Conclusion:

Reduction in routine Ultrasound surveillance following the COVID-19 pandemic was associated with a significant increase in access thrombosis rate. Further research is needed to unpick whether the associations seen were directly due to service changes, associated with COVID-19 or other factors during the pandemic. This association was independent of SARS-CoV-2 infection status. Clinical teams should consider alternative service delivery options including out-reach, bedside surveillance to balance risks of access thrombosis versus reducing the risk of nosocomial infection with hospital visits.
A vibration model of a flexible rotor-bearing system considering the defect in a double-row cylindrical roller bearing
Authors: Liu Jing , Fancheng Wanli , Li Xinbin , Ding Shizhao
Published: June 2023

Vibration analysis of double-row cylindrical roller bearing systems is useful for controlling the vibrations of rotating transmission systems. However, most current works only formulated the rotor system with single-row cylindrical roller bearings. Moreover, the vibration characteristics of the rotor system with defective double-row cylindrical roller bearings are not clearly. To overcome this problem, a vibration model of a flexible rotor system with the defective double-row cylindrical roller bearing is proposed in this work. The effects of the speed and defect on the vibrations of flexible rotor systems are studied. The vibrations from flexible and rigid models are compared under different rotation speeds. Note that the vibration waveforms from rigid and flexible models are similar. The vibrations of different nodes are different under different speeds, which cannot be formulated by the previous rigid models. The vibration model can better represent the vibrations of rotor systems with and without the defect. Moreover, this paper can provide a comprehensive analytical method for vibrations and acoustics of flexible rotor systems with the double-row cylindrical roller bearings.
Bandwidth-aware adaptive chirp mode decomposition for railway bearing fault diagnosis
Authors: Chen Shiqian , Guo Lei , Fan Junjie , Yi Cai , Wang Kaiyun , Zhai Wanming
Published: June 2023

It is a challenging task to accurately diagnose a railway bearing fault since bearing vibration signals are under strong interferences from wheel–rail excitations. The commonly used Kurtogram-based methods are often trapped in components induced by the wheel–rail excitations while adaptive mode decomposition methods are sensitive to input control parameters. To address these issues, based on a recently developed powerful signal decomposition method, that is, adaptive chirp mode decomposition (ACMD), a novel method called bandwidth-aware ACMD (BA-ACMD) is proposed in this article. First, the filter bank property of ACMD is thoroughly analyzed based on Monte-Carlo simulation and then a bandwidth expression with respect to the penalty parameter is first obtained by fitting a power law model. Then, a weighted spectrum trend (WST) method is proposed to partition frequency bands and then guide the parameter determination of ACMD through the integration of the obtained bandwidth expression. In addition, according to the order of magnitude of the WST in each band, the BA-ACMD adopts a recursive framework to extract signal modes one by one. In this way, dominating signal modes related to wheel–rail excitations can be extracted and then subtracted from the vibration signal in advance so that the bearing faults induced signal modes can be successfully identified. Both simulation and experimental validations are conducted showing that BA-ACMD can effectively detect single and compound faults of railway bearings under strong wheel–rail excitations.
Integrative Oncology’s 30-Year Anniversary: What Have We Achieved? A North American Naturopathic Oncology Perspective
Authors: Standish Leanna J. , Malani Sonia M. , Lynch Ksenia , Whinkin Emily J. , McCotter Carolyn M. , Lynch Duncan A. , Aggarwal Sunil K.
Published: June 2023

In 1991 the U.S. Congress mandated that the National Institutes of Health (NIH) form the Office of Alternative Medicine to study alternative medical therapies, especially in oncology care. Shortly after, the National Cancer Institute (NCI) created its own division of complementary and alternative medicine (Office of Complementary and Alternative Medicine). At the genesis of the field 30 years ago, what were we hoping to see accomplished by now? In this article we take a look back at milestones, shortfalls and future directions. Exciting opportunities exist to direct our established subspeciality’s future directions and we have made valuable advances the field of integrative oncology over the last 30 years: 1, IV high dose ascorbate has clinical research-based applications when used concurrently with some chemotherapeutic agents. 2. Whole body, extracorporeal and locoregional hyperthermia are being applied in treating solid tumors, including brain tumors. 3. PDL-1 tumor microenvironment testing and PDL-1 inhibitor immunotherapies have surprisingly excellent outcomes in a subgroup of cancer patients. 4. Tumor DNA sequencing (resected tumor and circulating tumor DNA in blood) has led to personalized precision targeted treatments. 5. Glucose metabolism’s role in cancer progression is better understood and better therapies are available (e.g., intermittent fasting, metformin). 6. Medical cannabis has a larger role in treating chemotherapy-related side effects and shows promise for anti-proliferative effects. 8. Greater understanding has been gained of the interdependence and mutual regulation of processes in psychoneuroendocrinoimmunology (PNEI). The burgeoning field of PNEI has exponentially expanded the discussion of tumorigenesis, apoptosis, and introduced to the field the investigation of more holistic approaches to immune regulation and cancer care. 8. Psychedelic-assisted psychotherapy is gaining traction especially for cancer patients facing demoralization, existential and spiritual distress, anxiety, depression and trauma related to the diagnosis and treatment of their cancer. 9. Spiritual health of cancer patients is more commonly addressed and measurable with an NIH validated scale. 10. Mind-Body therapies are efficacious for reducing cancer-related distress and are included in many cancer care programs.
Piloting a Flexible Solicited Diary Study With Marginalized Latina Women During the COVID-19 Pandemic
Authors: Seide Kapriskie , Casanova Felicia O. , Ramirez Esmeralda , McKenna Melanie , Cepeda Alice , Nowotny Kathryn M.
Published: June 2023

Little is known about the experiences of minority stress among Latina women who have sex with both women and men (WSWM), a sexual and gender minority group situated at the intersection of multiple marginalized identities. The current article presents an exploratory study aimed at addressing this knowledge gap. The research utilized a flexible diary-interview method (DIM) to investigate stress-related experiences among Mexican American WSWM residing in an economically disadvantaged community in the U.S. during the third wave of the COVID-19 pandemic. A detailed description of the study is provided, including information on the background, methodology, participants’ experiences, and how the project was managed remotely by a virtual research team. Twenty-one participants were asked to maintain a diary for a 6-week period spanning from March to September 2021. They submitted weekly entries in diverse formats (visual, audio, typed, and handwritten) through a user-friendly website or via mail while communicating regularly with researchers over the phone. Following the diarizing period, in-depth semi-structured interviews were conducted to clarify pertinent information within the entries and validate researchers’ preliminary interpretations. Out of the initial 21 enrollees, 14 participants stopped diarizing at different stages, and nine completed the entire study. Despite facing challenges exacerbated by the pandemic, participants reported the diary-keeping process as a positive experience that offered an authentic outlet to share parts of their lives they seldom reveal. The implementation of this study highlights two significant methodological insights. Firstly, it emphasizes the value of employing a DIM to explore intersectional narratives. Secondly, it underscores the importance of adopting a flexible and sensitive approach in qualitative health research, particularly when engaging individuals from minoritized groups.
A quartic trigonometric interpolatory spline with local free parameters
Authors: Li Juncheng , Liu Chengzhi
Published: June 2023

The construction of trigonometric interpolatory splines plays a very important role in geometric modeling. This paper presents a quartic trigonometric interpolatory spline with local free parameters. The new spline not only automatically interpolates the given points and achieves C2 continuity, but also owns shape adjustability when the points remain fixed. Some examples show that the shape of the new spline can easily realize local and global adjustment by changing the free parameters.
Spatial and temporal heterogeneity of digestive neuroendocrine neoplasms
Authors: Bourdeleau Pauline , Couvelard Anne , Ronot Maxime , Lebtahi Rachida , Hentic Olivia , Ruszniewski Philippe , Cros Jérôme , de Mestier Louis
Published: June 2023

Neuroendocrine neoplasms (NENs) are initially monoclonal neoplasms that progressively become polyclonal, with very different genotypic and phenotypic characteristics leading to biological differences, including the Ki-67 proliferation index, morphology, or sensitivity to treatments. Whereas inter-patient heterogeneity has been well described, intra-tumor heterogeneity has been little studied. However, NENs present a high degree of heterogeneity, both spatially within the same location or between different lesions, and through time. This can be explained by the emergence of tumor subclones with different behaviors. These subpopulations can be distinguished by the Ki-67 index, but also by the expression of hormonal markers or by differences in the intensity of uptake on metabolic imaging, such as 68Ga-somatostatin receptor and Fluorine-18 fluorodeoxyglucose positron emission tomography. As these features are directly related to prognosis, it seems mandatory to move toward a standardized, improved selection of the tumor areas to be studied to be as predictive as possible. The temporal evolution of NENs frequently leads to changes in tumor grade over time, with impact on prognosis and therapeutic decision-making. However, there is no recommendation regarding systematic biopsy of NEN recurrence or progression, and which lesion to sample. This review aims to summarize the current state of knowledge, the main hypotheses, and the main implications regarding intra-tumor spatial and temporal heterogeneity in digestive NENs.