bluuebunny/crossref_metadata_2025 huggingface dataset:
A new approach to the enigmatic language of Kurbskij and its seeming “anomalies”
Authors:   Institute of Slavic Languages and Literatures, University of Bern, Bounatirou Elias M.
Published: September 2021

In 2018, the author published a two-volume monograph in German entitled “Eine Syntax des ‘Novyj Margarit’ des A.M.Kurbskij. Philologisch-dependenzgrammatische Analysen zu einem kirchenslavischen Übersetzungskorpus” (“A Syntax of A.M.Kurbskij’s ‘Novyj Margarit’. A Philological and Dependency-grammatical Study of a Corpus of Church Slavonic Translations”). This article presents some results of the study in Russian and extends and complements the analysis begun in the monograph. The article focuses on the remarkable use of deverbal formations with the suffixes *-m- and *-n- having the meaning of passive necessity such as in до просвещаемы(х)/ad illuminandos ‘to those who have to be enlightened’. It is shown that the phenomenon in question, which can be observed in the Church Slavonic texts by Prince Andrei Kurbskij (1528–1583), should not be considered to be linguistically erroneous, as in the past. The fact that the use of the two formations mentioned is repeated in the same text and that examples of this phenomenon occur in different works by different authors suggests that it reflects a usage with a certain tradition. Consequently, the necessitative use of the deverbal suffixations has to be regarded as correct. In addition, a more systematic analysis makes it possible to show that a considerable number of other linguistic “anomalies” in Kurbskij’s works do not actually represent “anomalies”, or at least they are not linguistic errors of Kurbskij’s.
Ways of adapting Greekisms in the Slavic-Russian version of the Euchologion of the Great Church
Authors:   St. Petersburg State University, Molkov Georgiy A.
Published: September 2021

The Slavic-Russian translation of the Euchologion of the Great Church, made at the end of the 14th century by scribes from the circle of Metropolitan Cyprian, contains a large layer of exotic vocabulary. The purpose of this article is to describe the specifics of the adaptation of Greek vocabulary, borrowings, in this translation within the framework of Greek influence, which are known from the South Slavic translations of the 14th century. The article describes the differences concerning the degree of their morphological development, the relationship with their Slavic equivalent and with each other. Different ways of adapting the exoticisms are associated with their semantic heterogeneity in translation. The least ordered is the use of common noun vocabulary, denoting mainly objects of church use: each word that occurs repeatedly has its own set of declination variants. Proper names (or common nouns in the function of proper ones), as well as the names of heretical movements, were more consistently adapted. The frequency of such vocabulary in the Euchologion contributed to the development of typified means of its transmission. Along with techniques traditional for the 14th century for the Slavic tradition (glossing, deliberate use of unadapted foreign words), the translator also uses some new ways of adaptation, which can be considered as signs of the new wave of Greek influence. The new methods include cases of semantization of a variant of Greekism that differs from the traditional one, as well as methods of morphological and morphophonological adaptation of borrowings not known in the previous tradition.
Turkisms in one of the early Russian translations of the 18th century
Authors:   Institute for Linguistic Studies of the Russian Academy of Sciences, Sokolov Alexander I. , Malysheva Irina A. ,   Institute for Linguistic Studies of the Russian Academy of Sciences
Published: September 2021

The article considers Turkic borrowings in the Russian language at the beginning of the 18th century. The material of the study was a translation of the 17th century treatise “The History of the Present State of the Ottoman Empire” written by the English diplomat Paul Ricaut and translated into a number of European languages. The Russian translation was done by P.A.Tolstoy from the Italian version in 1702–1714 and published as “The Turkish Monarchy” in 1741. The study presents the methods of phonetic (orthographic) and morphological adaptation of Turkisms by comparing a typographical manuscript for typesetting with edits (made in 1725) and the printed text. The article aims at comparing the usage of borrowings with their forms in the Italian version of the treatise and in the Polish translation since the latter, apparently, was used in the process of typographical editing of the Russian text. A number ofdistorted forms of Turkisms that appeared in the Russian “Monarchy” as a result of the mechanical transfer of typos from the Italian translation were revealed. It has been established that the translation of compound nouns identified in the Turkic languages as izafet constructions was mainly a copying of their forms from the Italian translation. Most of the Turkisms in “The Turkish Monarchy” are exoticisms, but likely relevant for the Russian reader of the 18th century. Hence, the principles of including exoticisms in the “Dictionary of the Russian Language of the 18th Century” require clarification because a number of Turkisms denoting confessional concepts in modern Russian are part of active vocabulary.
On the role of the Novgorod tradition of Latin translations in the history of Russian language and culture: Lexical borrowings and unconscious fragments
Authors:   Università di Torino, Complesso Aldo Moro, Tomelleri Vittorio S.
Published: September 2021

The Latin influence upon Old Russian language and culture can be detected and studied at different levels (lexical, syntactical and phraseological). In addition to shortly discussing the different fates, on Russian soil, of two etymologically related words, biblija and biblioteka , this paper presents the particular case of an aphoristic quotation taken from the introduction to the Slavic translation of the Donatus . This proposal, pointing to the fundamental position of grammar within the system of the seven liberal arts (основание и подошва всем свободным хитростям — origo et fundamentum omnium liberalium artium), in later centuries has been referred to in different scientific works devoted to grammatical or pedagogical issues. However, there has not been any direct reference to the primary source and, as a consequence, these words have been subjected to different interpretations: from Maximus the Greek’s translation activity in Russia to the orthodox response to the challenge posed by Jesuit schools. The material collected and briefly discussed in the article points once again to the importance of taking into account, when approaching the tradition of Novgorod translations from Latin, not only the identification of the Urtext (direct tradition), but also its later reception and individual history (indirect tradition). Going beyond the temporal and spatial boundaries of Novgorod translated literature, we can examine its relevant and partially still unknown contribution to Russian cultural history within a broader and more stimulating perspective.
Techniques and Practices of Speech Expression in Arab Diplomatic Communication
Authors:   St. Petersburg State University, Akhmatshina Enesh K. , Demidova Kseniya Yu. ,   National Research University Higher School of Economics, Bykov Aleksei Yu. ,   St. Petersburg State University
Published: September 2021

The article is devoted to analysis of the techniques and practices of speech expression in Arab diplomatic communication through the example of speeches made by Arab diplomatic corps representatives and politicians at various UN venues. Original texts of speeches made by Permanent Representatives of Arab countries at the UN concerning the situation in the Middle East were chosen as the material for the study. The time frame covers the period from 2011 to 2018. The UN’s multimedia resources are one of the largest platforms for diplomatic dialogue open to the general public. Due to the intensification of relations between Russia and the Arab countries, it is necessary to identify the specifics of Arab diplomatic communication, as the speaker’s statements are not intended to express his or her own attitude and assessment, but the attitude of the state he or she represents. When analyzing the texts of speeches by diplomatic corps representatives in general, we observed the interpenetration and mutual influence of several types of language styles, which depend on the specifics of the issue under discussion: officialese style, inherent in diplomatic correspondence, and publicistic, which is found in public speeches. The intermingling of styles undoubtedly affects both the lexical and syntactic weight of the texts in a statement. In turn, Arab speakers cannot remain emotionally indifferent to the problems of their region due to the difficult political situation in the Middle East. For this reason, we noted not only a regular deviation from diplomatic speech standards, primarily the abundance of emotionally evaluative vocabulary in the texts of their speeches, but also special strategies for constructing texts that help to have a certain effect directed at listeners and opponents — expression. Among the most commonly used methods of speech expression, we have identified repetition, cohesion, convergence and the effect of defeated expectancy. By means of analysis of expressive syntaxes we studied the specifics of the use of these methods of speech expression at the level of usual-clichéd Arabic text and highlighted the specifics of tapping this speech strategy in the language of Arabic diplomacy.
A matrix for museological diagnostics and planning
Authors:   Université de Liége, Duarte Cândido Manuelina Maria
Published: September 2021

The article presents a theoretical discussion that provides support for the development of a methodological tool to assess and plan the activities of museums or musealisation processes. According to the author, a matrix for museological diagnostics, planning and management should be used to create or renovate small or large, conventional or unconventional museums. This work is the result of PhD research that produced a book already in its third edition in Brazil. For the creation of the matrix, an attempt was made to identify the common aspects among different types and museum models. The proposed concept includes a theoretical and conceptual discussion, as well as the establishment of a museological structure or tool to justify work in this field. These aspects will be discussed in this article, as well as the details of their contributions to applied research in museology and to the qualification of museums. The matrix resulting from this research can be used to not only carry out museological diagnostics or institutional evaluations of existing museums, but also as a reference framework for the creation of new museums and for musealization processes. In the article, significant attention is given to clarifying the use of the terms used in the matrix in order to allow its interpretation and application in a variety of cases based on precise museological thought. Thus, theory and practice are concerned with understanding and using this matrix for museological diagnostics and planning.
University museums of the Silesian Voivodeship (Republic of Poland)
Authors:   University of Gdańsk, Bragin Aisen S.
Published: September 2021

The article considers the scientific basis for the study of the activities of university museums by Polish scientists. The main support for Polish university museums is said to be provided by the Association of University Museums (AUM). The author analyzes its research and popularization activities. The main purpose of the work is to study the history of the formation and development of six university museums of the Silesian Voivodeship in the Republic of Poland: “Museum of Geology of Deposits named after Czeslaw Poborsky at the Faculty of Mining and Geology of the Silesian University of Technology”, “Museum of the Faculty of Geosciences of the University of Silesia”, “Museum of Silesian Organs”, “Center for History and Traditions of the University of Economics in Katowice”, “Museum of Technology of the Silesian University of Technology” and the “Museum of Medicine and Pharmacy in Sosnowiec”. The author also examines their collections and exhibitions. Theoretical research in the field of studying university museums is considered in detail. For the analysis, scientific articles, books, brochures, mass media materials and information on museum websites are used in order to provide a complete picture of the historical and current state of university museums in the region. In the process of writing the article, the author contacted several guardians and university museum staff to clarify the dates and information provided in various sources. The work partially uses their responses received by e-mail, with the indication of information about the source.
Sources of acquisition of the collections of the Khorinsky District Museum of History and Local Lore
Authors:   Khorinsky District Museum of History and Local Lore, Truneva Liubov A. , Puzankov Yurii V. ,   Irkutsk State University
Published: September 2021

The article is devoted to the history of the acquisition of collections of the Khorinsky District Museum of History and Local Lore at various stages of its development, from its establishment to the modern period of its activity. The Khorinsky District Museum of History and Local Lore was founded on November 10, 1979. Its appearance testified to the economic and cultural development of the Khorinsky district. The created museum has become one of the centers to spread the district’s culture, accessible to the general population. Modern expositions of the museum make it possible to trace the history of the Khorinsky district at all stages of its existence, covering, among other things, the prehistoric era. Based on information from the inventory book, as well as on the basis of their own memories, the authors reconstruct the sources of museum’s collections after a fire occurred in the museum in December 1984. The damage turned out to be so serious that only 22 items, mostly large-sized ones, such as carts, sledges, and a lathe, were preserved. The restoration work in the museum was carried out under the leadership of director Innokenty Yakovlevich Trunev, whose active work made it possible to practically re-form the museum’s collections. The authors of the article describe in detail the goals pursued by the donors and creators of the items given to the museum. Most of the exhibits were collected as a result of trips. A significant source for the museum’s collections was the result of local residents donating items. Items were handed over to the museum that appear both simple, at first glance, from every day use and unique items, family heirlooms. The republic’s (Buryatia) museums rendered great support in the formation of the museum’s collections. A significant number of items were found as a result of scientific expeditions and subsequently transferred to the museum.
The ideal essence of a museum object
Authors:   Tula State Museum of Weapons, Gerasimov Grigoriy I.
Published: September 2021

The article examines the museum object from the theoretical and methodological positions of the idealistic approach, placing the Human Creator at the center of culture and history. The museum object is characterized as a substance of nature from the theoretical point of view. Also, it is designed in accordance with the ideological content of human consciousness and having value from the point of view of the main ideas of society’s worldview. An explanation of the phenomenon of information of a museum object is provided in the article. The process of endowing a museum object with such a specific property as museum character is substantiated and the procedure for its creation is described. At the same time, it is indicated that the main properties of a museum object are not immanent, but they are instilled in it by the consciousness of a museum worker and a visitor. The value of a museum object is determined by the ideas of the dominant worldview; when it changes, the value of the museum object also changes. The degree of expression of the main properties of a museum object such as expressiveness, attractiveness, and associativity also depend on the ideas of the current worldview. Original objects that sufficiently express the main content of the subject are of the greatest value. From the authors’ positions, criticism of views on the most important properties of a museum object is made. From the standpoint of an idealistic approach, a definition of authenticity of a museum object is provided and the particular importance of authentic objects inthe current time of multimedia and interactive technologies being introduced into museum practices is emphasized. The article concludes that the idealistic approach, offering a solution to many problems in relation to a museum object, nevertheless, is not at the moment an all-encompassing theory that can explain it in all manifestations of creation and functioning. However, according to the author, in comparison with other theories the idealistic approach is able to give more answers to questions in this area than other museological concepts.
The fate of museums and historical monuments of Karabakh
Authors:   Azerbaijan University of Tourism and Management, Qafarova Gunay N. , Mirseyibli Sadi A. ,   Independence Museum of Azerbaijan
Published: September 2021

The article presents a brief history of relations between the Armenian and Azerbaijani population of Karabakh and provides a concise chronological sequence of the resettlement of Armenians. It focuses on the consequences of the conflict that lasted for 30 years. As a result of the conflict, cultural heritage sites were destroyed on the territory of the unrecognized Nagorno-Karabakh Republic and millions of residents lost their homes when they were evicted from their ancestral lands. The investigated events brought a significant amount of troubles and sufferings to the Azerbaijani people, the number of its victims is estimated in the thousands. The Khojaly tragedy went down in history as the cruelest massacre of the civilian population. The military clash affected not only the population, but also the cultural heritage of the Azerbaijani people. Karabakh was the birthplace of many leading figures of Azerbaijani culture, such as Uzeyir Hajibeyli (Hajibeyov), Bulbul, Rashid Behbudov and others. Before joining the Russian Empire, these territories were part of the Karabakh Khanate and its main city was the impenetrable fortress of Shusha, the main population of which was Azerbaijanis. However, after joining Russia, Armenians from Iran, Turkey, and Syria began to move to these territories. After the creation of the Azerbaijan Soviet Socialist Republic, this region was preserved in its structure under the name of the Nagorno — Karabakh Autonomous Region, which later became a bone of contention between the two peoples. Emphasis in the article is given to museums and historical monuments destroyed as a result of the conflict. On the basis of facts, the authors trace the milestones of the destruction of the Azerbaijani cultural heritage — archaeological sites, museums, mausoleums, mosques, and churches. Ancient Albanian temples underwent armenization. Attention is drawn to the facts of violation of international conventions and normative legal acts on the preservation of cultural heritage.
YÜKSEKÖĞRETİM MEZUNLARININ GENEL YETERLİLİK DÜZEYLERİ İLE İŞ YAŞAMINDA BEKLENEN YETERLİLİKLERİN KARŞILAŞTIRILMASI: FİZYOTERAPİ VE REHABİLİTASYON LİSANS PROGRAMI ÖRNEĞİ
Authors: MADAN Mustafa , ÜLGER Özlem , AKSU YILDIRIM Sibel
Published: September 2021

Amaç: Genel yeterlilikler belirli bir mesleğe özgü olmayan yeterliliklerdir. Literatürde istihdam edilebilirlik becerileri, transfer edilebilir beceriler ve 21. yüzyıl yeterlilikleri gibi kavramlarla da ifade edilen bu yeterliliklerin istihdam ve kariyer açısından önemi giderek artmaktadır. Bu araştırma fizyoterapi ve rehabilitasyon lisans mezunlarının genel yeterlilik düzeyleri ile çalışmakta oldukları işin gerektirdiği yeterlilik düzeylerini tespit etmek, karşılaştırmak ve beceri uyuşmazlığını sorgulamak amacıyla gerçekleştirildi.
Yöntem: Araştırma Mart-Aralık 2018 tarihleri arasında çevrimiçi anket yöntemiyle gerçekleştirildi. Araştırmaya 2012 yılında mezun veren tüm fizyoterapi ve rehabilitasyon lisans programlarının mezunları davet edildi. Analiz için uygun 240 katılımcının yanıtları çalışmaya dahil edildi.
Sonuçlar: Mezunların sahip oldukları en yüksek yeterlilik düzeyinin “kendi alanına ya da disiplinine hakimiyet” konusunda olduğu belirlendi. Çalışılan işte en yüksek düzeyde istenen yeterlilik “zamanı etkili kullanabilme” idi. Sorgulanan 22 yeterlilikten 18’inde mezunlar kendi yeterlilik düzeylerini, iş için istenen yeterlilik düzeylerinden daha yüksek olarak değerlendirdiler. İş için istenen yeterlilik düzeyinin mezun düzeylerinden istatiksel anlamda daha yüksek olduğu tek yeterlilik “baskı altında çalışabilme” idi (p=0,020), aynı zamanda “baskı altında çalışabilme” beceri açığının en fazla olduğu yeterlilik idi.
Tartışma: Sonuçlar mezunlarda algılanan aşırı nitelikli olma halinin yaygın olduğunu göstermektedir. Buna karşın araştırma sonuçlarımız baskı altında çalışabilme yeterliliği ve verimli zaman yönetimi konusunun lisans eğitimi sürecinde kapsamlı olarak ele alınması gerektiğini ortaya koymaktadır.
Prevention and Management of Type II Diabetes Chronic Complications:
The Role of Polyphenols (Mini-Review)
Authors: Pani Arianna , Baratta Francesco , Pastori Daniele , Coronati Mattia , Scaglione Francesco , del Ben Maria
Published: September 2021

The numerous complications of diabetes may be at least in part generated by
the oxidative stress associated with the constant state of hyperglycemia. Polyphenols are
plant-based secondary metabolites that have high potentials in the prevention and treatment
of some diseases, in particular those that involve oxidative stress, such as complications
of diabetes. The purpose of this narrative review is to show the main evidence regarding
the role of polyphenols in treating and preventing these complications. For the
bibliographic research, the papers published up to March 15, 2021, were considered, and
the search terms included words relating to polyphenols, their classes and some more
known compounds in association with the complications of diabetes.
There are numerous studies showing how polyphenols are active against endothelial damage
induced by diabetes, oxidative stress and hyperinflammatory states that are at the origin of
the complications of diabetes. Compounds such as flavonoids, but also anthocyanins, stilbenes
or lignans slow the progression of kidney damage, prevent ischemic events and diabetic
nephropathy. Many of these studies are preclinical, in cellular or animal models.
The role of polyphenols in the prevention and treatment of diabetes complications is undoubtedly
promising. However, more clinical trials need to be implemented to understand
the real effectiveness of these compounds.
sFlt-1: A Double Regulator in Angiogenesis-related Diseases
Authors: Liao Li , Zhao Xingtao , Zhou Mengting , Deng Ying , Li Yunxia , Peng Cheng
Published: September 2021

Background:

Vascular endothelial growth factor (VEGF) is a supergene family derived from a
platelet growth factor. It plays a pivotal role in regulating angiogenesis and lymphangiogenesis. sFlt-1 is a soluble
antagonist of VEGF with an essential effect of maintaining the balance of vascular growth. Recently, sFlt-1
has emerged as a new marker for early diagnosis and disease surveillance of angiogenesis-related diseases.
However, few comprehensive reviews focus on the relationship between sFlt-1 and related diseases despite that
many results have yielded.

Methods:

In this review, we analyzed the relationship between sFlt-1 and angiogenesis-related diseases by
searching PubMed, Web of Science, and other databases, and summarized our current understanding of the role
of sFlt-1 in angiogenesis-related diseases.

Results:

sFlt-1 is associated with pre-eclampsia, perinatal cardiomyopathy, diabetic nephropathy, hypertension,
tumor, atherosclerosis, and other diseases. The mechanisms of sFlt-1 that regulate those diseases are mainly associated
with the bioavailability of VEGF and vascular endothelial cell integrity.

Conclusion:

From the summary article, sFlt-1 is a double regulator in angiogenesis-related diseases; too much
or too little may cause different diseases. Therefore, maintaining the stability of sFlt-1 content in the body is essential
to control the development of related diseases.
Preparation and Evaluation of Valnemulin Hydrochloride Taste-Masking Granules
Authors: Chen Dongmei , Xie Shuyu , Liang Yongjie , Hu Danlei , Yan Yuanyuan
Published: September 2021

Background:

The bitter taste and strong irritation of valnemulin hydrochloride limit its
wide clinical application in pigs by oral.

Method:

In order to improve its palatability and residence time in the body, the valnemulin hydrochloride
taste-masking granules with sustained-release were prepared by combining solid dispersion
based on fatty acid with wet granulation. The formulation was screened by orthogonal test
with content, yield, grain size and angle of repose as evaluation indexes.

Result:

The results showed that the optimal granules were composed of corn starch, sucrose, citric
acid, valnemulin hydrochloride and myristic acid at a ratio of 40: 20: 20: 11: 19. The daily feed intake
of pigs in the optimum taste-masking granule groups was similar to that of its self-control, and
significantly higher than that in the valnemulin hydrochloride active ingredient group, suggesting
that the optimum granules have satisfactory palatability. The prepared granules improved the oral
bioavailability of valnemulin hydrochloride by 3.04 folds and extended its mean residence time (MRT)
by 2.33 folds.

Conclusion:

The granules developed in this study could obviously improve the palatability and sustained
release of valnemulin hydrochloride. The producing method of granules by combining solid
dispersion powder with wet granulation can provide ideas for other drugs with poor palatability
and a short half-life.
The Medicinal Chemistry of 3-nitro-1,2,4-triazoles: Focus on Infectious Diseases
Authors: França Rodolfo Rodrigo Florido , Menozzi Cheyene Almeida Celestino , Castelo-Branco Frederico Silva , Hoelz Lucas Villas Bôas , Boechat Nubia
Published: September 2021

:

Infectious diseases are among the leading causes of death worldwide, especially in developing
countries. The historical lack of interest of the pharmaceutical industry in developing new
drugs against many of these diseases, such as tuberculosis, leishmaniasis, Chagas disease, sleeping
sickness, and fungal infections, has left millions of individuals dependent on old treatments that are
often ineffective and present different adverse effects. In this sense, new substances against these
diseases must be identified. A class of substances that has stood out in the search for new drugs
against these diseases is azole derivatives. Within this class, the 3-nitro-1,2,4-triazole nucleus has
attracted increasing interest due to its potential, specifically when compared to the 1,2,4-triazole nucleus
without the presence of the nitro group, and also in relation to the 2-nitroimidazole nucleus,
showing greater potency and selectivity against different etiological agents. This is even more relevant
considering that 3-nitro-1,2,4-triazolic substances can promote their activity through different
mechanisms of action, such as the inhibition of ergosterol biosynthesis and also via activation by
the nitroreductase enzyme, which can avoid the development of cross-resistance. Therefore, in this
review, the medicinal chemistry of nitrotriazoles is discussed through the analysis of their potential
in terms of biological activity against the etiological agents of several diseases, such as Chagas disease,
sleeping sickness and leishmaniasis, caused by kinetoplastid parasites, tuberculosis, caused by
the mycobacteria Mycobacterium tuberculosis, and against different species of pathogenic fungi. In
addition, aspects related to enzymatic activities, molecular modeling and organic synthesis of these
substances are also addressed.
Lymphadenopathy as a Prodrome for Systemic Lupus Erythematous
Authors: Kinariwalla Neha , Steed Kelly , Mundi Prabjot S.
Published: September 2021

Background:

Lupus lymphadenopahy (LL) has an estimated incidence of 1% at diagnosis.
Here, we report a case of systemic lupus erythematous which presented with a prodrome of generalized
lymphadenopathy and fevers.

Case Presentation:

A 41-year-old woman presented to the hospital with one month of fevers,
chills, lymphadenopathy, abdominal pain, a bilateral upper extremity rash, and malaise. Physical
exam was notable for tender, palpable posterior cervical lymph nodes that were mobile and about 1
cm in maximum diameter. After extensive infectious, hematologic, and autoimmune evaluations, a
diagnosis of systemic lupus erythematous (SLE) was made and treatment with high-dose steroids
and hydroxychloroquine which resulted in gradual improvement in symptoms.

Conclusion:

Systemic lupus erythematous can present with a subtle prodrome of generalized lymphadenopathy.
It is important for medical professionals to consider SLE in the differential in a patient
with diffuse lymphadenopathy.
Exploring the Hypothesis of a Schizophrenia and Bipolar Disorder Continuum:
Biological, Genetic and Pharmacologic Data
Authors: de Sousa Teresa Reynolds , DT Correia , Novais Filipa
Published: September 2021

:

Present time nosology has its roots in Kraepelin’s demarcation of schizophrenia and
bipolar disorder. However, accumulating evidence has shed light on several commonalities between
the two disorders, and some authors have advocated for the consideration of a disease continuum.
Here, we review previous genetic, biological and pharmacological findings that provide the
basis for this conceptualization. There is a cross-disease heritability, and they share single-nucleotide
polymorphisms in some common genes. EEG and imaging patterns have a number of similarities,
namely reduced white matter integrity and abnormal connectivity. Dopamine, serotonin,
GABA and glutamate systems have dysfunctional features, some of which are identical among the
disorders. Finally, cellular calcium regulation and mitochondrial function are, also, impaired in the
two.
Impact of Sitagliptin on Non-diabetic Covid-19 Patients
Authors: Batiha Gaber El-Saber , Al-kuraishy Hayder M. , Al-Gareeb Ali I. , Qusty Naeem , Alexiou Athanasios
Published: September 2021

Objective:

In coronavirus disease 2019 (Covid-19), SARS-CoV-2 may use dipeptidyl peptidase 4 (DPP4) as an entry-point in different tissues expressing these receptors. DPP4 inhibitors (DPP4Is), also named gliptins, like sitagliptin, have anti-inflammatory and antioxidant effects, thereby lessen inflammatory and oxidative stress in diabetic Covid-19 patients. Therefore, the present study aimed to illustrate the potential beneficial effect of sitagliptin in managing Covid-19 in non-diabetic patients.

Methods:

A total number of 89 patients with Covid-19 were recruited from a single center at the time of diagnosis. The recruited patients were assigned according to the standard therapy for Covid-19 and our interventional therapy into two groups; Group A: Covid-19 patients on the standard therapy (n=40) and Group B: Covid-19 patients on the standard therapy plus sitagliptin (n=49). The duration of this interventional study was 28 days according to the guideline in managing patients with Covid-19. Routine laboratory investigations, serological tests, Complete Blood Count (CBC), C-reactive Protein (CRP), D-dimer, lactate dehydrogenase (LDH), and serum ferritin were measured to observed Covid-19 severity and complications. Lung Computed Tomography (CT) and clinical scores were evaluated.

Results:

The present study illustrated that sitagliptin as an add-on to standard therapy improved clinical outcomes, radiological scores, and inflammatory biomarkers than standard therapy alone in non-diabetic patients with Covid-19 (P<0.01).

Conclusions:

Sitagliptin as an add-on to standard therapy in managing non-diabetic Covid-19 patients may have a robust beneficial effect by modulating inflammatory cytokines with subsequent good clinical outcomes.
Диссоциативная рекомбинация в послесвечении барьерного разряда в неоне низкого давления. Заселение атомов конфигурации 2p-=SUP=-5-=/SUP=-3d
Authors: Иванов В.А.
Published: September 2021

The decaying neon plasma produced by the dielectric barrier discharge (DBD) in a cylindrical tube at a pressure of 0.1–40 Torr has been spectroscopically investigated to analyze the dissociative recombination (DR) of molecular ions with electrons as a mechanism for the formation of excited atoms. It is shown that, at the electron density in the afterglow less than 5•1010 cm-3 the DR is the dominant source of population of 3d levels at pressures PNe ≥ 0.6 Torr. At lower pressures, the optical properties of the decaying plasma are formed to a greater extent by the collisional-radiative recombination of Ne+ ions. A significant variation of the relative intensities of the 3d -> 3p transition lines in the afterglow with a change in gas pressure was found, reflecting the effect of inelastic collisions on the formation of the spectrum of decaying plasma in the near infrared region. From measurements carried out at a pressure of 0.6 Torr, the relative values of the partial DR coefficients for the 3dj levels of the neon atom were found. Comparison of these data with measurements in the near ultraviolet region, containing the lines of 4p -> 3s transitions, indicates the need to take into account the cascade 4p -> 3d transitions to correctly solve the problem of the final products of dissociative recombination.
Новый метод определения распределения плотности электронных состояний в хвосте валентной зоны аморфных твердых растворов Se-=SUB=-x-=/SUB=-S-=SUB=-1-x-=/SUB=-
Authors: Икрамов Р.Г. , Нуриддинова М.А. , Муминов Х.А.
Published: September 2021

Сопоставлены аналитическое выражение и экспериментальная кривая спектра экспоненциального поглощения аморфного селено-серного твердого раствора (Se0.5S0.5 и Se0.7S0.3). Параметры в аналитическом выражении спектра экспоненциального поглощения, определяющие кривизну экспоненциальных хвостов разрешенных зон, найдены путем аппроксимации экспериментальной кривой. Используя приближение Дэвиса-Мотта по формуле Кубо-Гринвуда для спектра экспоненциального поглощения получена новая формула, определяющая плотности электронных состояний в хвосте валентной зоны. С использованием этой формулы и экспериментально определенного спектра экспоненциального поглощения показана возможность определения плотности электронных состояний в хвосте валентной зоны. Ключевые слова: аморфные полупроводники, хвосты разрешенных зон, формула Кубо-Гринвуда, метод приближения Дэвиса-Мотта, оптические электронные переходы, спектр экспоненциального поглощения, параметры, определяющие крутизну хвостов разрешенных зон, распределение плотности электронных состояний.
A novel method of plasmon coupled optical waveguide for aerosol sensor-=SUP=-*-=/SUP=-
Authors: Kumar Sushil , Sharma Gaurav , Yadav Gulab Chand , Singh Vivek , Singh Abhay Kumar
Published: September 2021

The tropospheric aerosol characterization is important for understanding environmental process as well as human health safety. In this study, the surface plasmon resonance sensor is proposed for the detection of ammonium sulfate which is an important component of aerosols. The reflectivity of proposed sensor waveguides is calculated as a function of the incident angle using the transfer matrix method. The performance of proposed sensors having sol-gel film of tetraethylorthosilane and thymolblue are studied and compared. Firstly, the dispersion characteristics are obtained for different modes, and it is observed that the modes are tightly bound in thymol blue waveguide in comparison to tetraethylorthosilane waveguide. Further, the magnetic field distributions are also studied and compared for proposed waveguide sensor configurations. It is found that the sol-gel film of thymol blue waveguide provides high sensitivity while tetraethylorthosilane waveguide shows high figure of merit. Keywords: aerosol, surface plasmon resonance sensor; reflectivity, sensitivity, detection accuracy.
Analysis of Posts on Social Network Service related to Panic Disorder using Text Mining (Preprint)
Authors: Jeon Moon-Ju , Bae Sung-Man
Published: September 2021

BACKGROUND

Panic attacks have different clinical characteristics among individuals and countries, characterizing time, place, and symptoms are not clearly predictable

OBJECTIVE

This study aimed to analyze crucial keywords related to panic disorder and identify various clinical characteristics of panic attacks

METHODS

We collected 8,728 Twitter posts related to panic disorder from January 1 to December 4, 2020. First, we analyzed crucial and simultaneous emergence keywords related to panic disorder. For this, Term frequency, Term Frequency-Inverse Document Frequency, degree centrality, and N-gram analyses were conducted using Rstudio and TEXTOM and visualized as word clouds. Also, we classfied results of Term frequency for panic disorder into physical symptoms, triggers, time, place, affect, pathology, person, and coping.

RESULTS

First, depression, drugs, respiration, and stress were keywords related to panic disorder. Next, hyperventilation, palpitations, and shaking were common physical symptoms. Stress, sound, trauma, and coffee were also ranked high in terms of triggering situations. Additionally, in terms of time, morning, night, and dawn accounted for most of the time. Meanwhile, homes, schools, subways, and companies were ranked high as places of occurrence. Regarding affect, fear, tears, and embarrassment were also common. Furthermore, anxiety and depression were ranked high in terms of pathology. Finally, drugs and hospitals were ranked high in terms of coping.

CONCLUSIONS

These results help to understand the main characteristics of panic disorder and various aspects of unexpected panic attacks and are expected to be a basis for identifying the characteristic clinical aspects of panic disorder among Koreans.
Correction: Distant Supervision for Mental Health Management in Social Media: Suicide Risk Classification System Development Study (Preprint)
Authors: Fu Guanghui , Song Changwei , Li Jianqiang , Ma Yue , Chen Pan , Wang Ruiqian , Yang Bing Xiang , Huang Zhisheng
Published: September 2021

BACKGROUND

Web-based social media provides common people with a platform to express their emotions conveniently and anonymously. There have been nearly 2 million messages in a particular Chinese social media data source, and several thousands more are generated each day. Therefore, it has become impossible to analyze these messages manually. However, these messages have been identified as an important data source for the prevention of suicide related to depression disorder.

OBJECTIVE

We proposed in this paper a distant supervision approach to developing a system that can automatically identify textual comments that are indicative of a high suicide risk.

METHODS

To avoid expensive manual data annotations, we used a knowledge graph method to produce approximate annotations for distant supervision, which provided a basis for a deep learning architecture that was built and refined by interactions with psychology experts. There were three annotation levels, as follows: free annotations (zero cost), easy annotations (by psychology students), and hard annotations (by psychology experts).

RESULTS

Our system was evaluated accordingly and showed that its performance at each level was promising. By combining our system with several important psychology features from user blogs, we obtained a precision of 80.75%, a recall of 75.41%, and an F1 score of 77.98% for the hardest test data.

CONCLUSIONS

In this paper, we proposed a distant supervision approach to develop an automatic system that can classify high and low suicide risk based on social media comments. The model can therefore provide volunteers with early warnings to prevent social media users from committing suicide.
Remote Monitoring of Patients With Hematologic Malignancies at High Risk of Febrile Neutropenia: Exploratory Study (Preprint)
Authors: Kroloff Maxwell , Ramezani Ramin , Wilhalme Holly , Naeim Arash
Published: September 2021

BACKGROUND

Febrile neutropenia is one of the most common oncologic emergencies and is associated with significant, preventable morbidity and mortality. Most patients who experience a febrile neutropenia episode are hospitalized, resulting in significant economic cost.

OBJECTIVE

This exploratory study implemented a remote monitoring system comprising a digital infrared thermometer and a pulse oximeter with the capability to notify providers in real time of abnormalities in vital signs that could suggest early clinical deterioration and thereby improve clinical outcomes.

METHODS

The remote monitoring system was implemented and compared to standard-of-care vital signs monitoring in hospitalized patients with underlying hematologic malignancies complicated by a febrile neutropenia episode in order to assess the feasibility and validity of the system. Statistical analysis was performed using the intraclass correlation coefficient (ICC) to assess the consistency between the measurements taken using traditional methods and those taken with the remote monitoring system for each of the vital sign parameters (temperature, heart rate, and oxygen saturation). A linear mixed-effects model with a random subject effect was used to estimate the variance components. Bland-Altman plots were created for the parameters to further delineate the direction of any occurring bias.

RESULTS

A total of 23 patients were enrolled in the study (mean age 56, SD 23-75 years; male patients: n=11, 47.8%). ICC analysis confirmed the high repeatability and accuracy of the heart rate assessment (ICC=0.856), acting as a supplement to remote temperature assessment. While the sensitivity and specificity for capturing tachycardia above a rate of 100 bpm were excellent (88% and 97%, respectively), the sensitivity of the remote monitoring system in capturing temperatures >37.8 °C and oxygen saturation <92% was 45% and 50%, respectively.

CONCLUSIONS

Overall, this novel approach using temperature, heart rate, and oxygen saturation assessments successfully provided real-time, clinically valuable feedback to providers. While temperature and oxygen saturation assessments lagged in terms of sensitivity compared to a standard in-hospital system, the heart rate assessment provided highly accurate complementary data. As a whole, the system provided additional information that can be applied to a clinically vulnerable population. By transitioning its application to high-risk patients in the outpatient setting, this system can help prevent additional use of health care services through early provider intervention and potentially improve outcomes.
Высокотемпературная высокоэффективная жидкостная хроматография. Краткий обзор
Authors: Яшин А.Я. , Яшин Я.И. , Родченкова В.В.
Published: September 2021

Обсуждаются особенности высокотемпературной высокоэффективной жидкостной хроматографии (ВТ ВЭЖХ). Перечислены методы ВЭЖХ, в которых используются высокие температуры, а также детекторы и сорбенты, применяемые в условиях высоких температур. Рассмотрены области применения и показаны основные преимущества ВТ ВЭЖХ: значительное сокращение времени разделения, повышение эффективности колонок, возможность применения чистой воды в качестве элюента. Отмечено отрицательное влияние высоких температур на стабильность как разделяемых соединений, так и сорбентов.
Rhizoma Drynariae protects against Canaglifloxacin induced bone loss
Authors:   Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia., Alqahtani Ali , Asseri Khalid A ,   Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia., Asiri Yahya I ,   Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia., Venkatesan Krishnaraju ,   Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia., Khan Noohu Abdulla ,   Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia, Alavudeen Sirajudeen Shaik ,   Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia, Pappiya Ester Mary ,   Directorate of General Health Affair, Ministry of Health, Najran, KSA, Paulsamy Premalatha ,   King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia, Natarajan R. ,   Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India, Krishnaraju Kalpana ,   Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India, Venkatesan Kumar ,   Department of Chemistry, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia., Chidambaram Kumarappan ,   Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia.
Published: September 2021

Osteoporosis is a condition marked by a loss of bone mass and degradation of the bone microstructure, both of which lead to increased fragility and consequent fragility fractures, particularly in the elderly. Rhizoma Drynariae (DRE) is one of the most often used herbal remedies for osteoporosis therapy. Transdermal drug administration is a well- established new method for drug delivery that offers numerous benefits over conventional routes. Wistar albino rats were split into five groups of six rats each: vehicle control, diabeticgroup, DRE group, Canagliflozin (CGF), and CGF + DRE group. Each medication was given by gastric gavage once a day for 35 days. The drug canagliflozin appears to raise the risk of fractur. When compared to the control group, DRE treatment increased bone strength at the femoral diaphysis in osteoporotic fractures in rats by increasing ultimate load and stiffness. The goal of this study is to investigate the anti-osteoporosis effects of DRE in diabetic rats co-treated with CGF. Blood glucose levels and bone mineral density (BMD) were measured. According to the data, DRE produced a significant increase in bone amount. DRE may help prevent and cure diabetic osteoporosis by increasing bone mineral density, according to one study. Keywords: Rhizoma Drynariae Diabetic osteoporosis, Streptozotocin induced diabetes, Canagliflozin