bluuebunny/crossref_metadata_2025 huggingface dataset:
Les collections de vêtements d’enfant, problèmes et perspectives
Authors: Guennec Aude Le , Rose Clare
Published: April 2024

La mode enfantine reste un sujet muséologique marginal dans le paysage muséographique contemporain et principalement dans les institutions qui devaient en avoir la charge : les musées de mode et musées de société. Reflétant l’intérêt tardif pour l’histoire de l’enfance, la mode enfantine a rarement fait l’objet d’une collecte patrimoniale et d’une documentation cohérente dans ces institutions. Par ailleurs, reposant généralement sur des dons familiaux aléatoires, les collections ne montrent pas la réalité et les usages des vêtements du quotidien dans toutes les couches de la société. Du fait de la disparition de cette mémoire matérielle enfantine, les musées négligent les pratiques vestimentaires des enfants et les excluent des processus de patrimonialisation de leur culture quand bien même ceci est l’un de leurs droits fondamentaux (Convention relative aux droits de l’enfant, 1989). À travers trois études de cas de musées français et britanniques particulièrement associés à la conservation et à la valorisation de l’histoire de la mode enfantine, cet article analyse l’état actuel du patrimoine vestimentaire enfantin et son effet sur notre compréhension des mécanismes de socialisation des enfants. Il explore les avantages d’une approche patrimoniale cohérente pour préserver la mémoire de la mode enfantine, comprendre les interactions des enfants avec leur propre culture, et envisager les perspectives que cette approche pourrait apporter aux jeunes en termes d’éducation et de citoyenneté.
Children’s clothing collections, problems and perspectives
Authors: Guennec Aude Le , Rose Clare
Published: April 2024

Children's fashion remains a marginal museological subject in the contemporary museographic landscape and in particular in the institutions that should be in charge of this topic: fashion and local history museums. Reflecting the late interest in childhood history, children's fashion has rarely been the subject of strategic collection and coherent documentation in these institutions. Moreover, generally based on random family donations, the collections do not document everyday clothing and dress codes across society. Because of the disappearance of this heritage, museums neglect children's clothing practices and prevent young people from accessing the history of their material culture despite this being one of their fundamental rights (United Nations Convention on the Right of the Child). Through three case studies of French and British museums associated in different ways with the collection and study of the history of children's fashion, this article analyzes the current state of children's clothing heritage and the effect the marginalisation of children dress history has on our understanding of the socialization of children. It explores the advantages of a strategic approach to preserving the memory of childhood clothing, understanding the interactions of children with their culture, and considering the perspectives that this approach could bring to young people in terms of education and social participation.La mode enfantine reste un sujet muséologique marginal dans le paysage muséographique contemporain et principalement dans les institutions qui devaient en avoir la charge : les musées de mode et musées de société. Reflétant l’intérêt tardif pour l’histoire de l’enfance, la mode enfantine a rarement fait l’objet d’une collecte patrimoniale et d’une documentation cohérente dans ces institutions. Par ailleurs, reposant généralement sur des dons familiaux aléatoires, les collections ne montrent pas la réalité et les usages des vêtements du quotidien dans toutes les couches de la société. Du fait de la disparition de cette mémoire matérielle enfantine, les musées négligent les pratiques vestimentaires des enfants et les excluent des processus de patrimonialisation de leur culture quand bien même ceci est l’un de leurs droits fondamentaux (Convention relative aux droits de l’enfant, 1989). À travers trois études de cas de musées français et britanniques particulièrement associés à la conservation et à la valorisation de l’histoire de la mode enfantine, cet article analyse l’état actuel du patrimoine vestimentaire enfantin et son effet sur notre compréhension des mécanismes de socialisation des enfants. Il explore les avantages d’une approche patrimoniale cohérente pour préserver la mémoire de la mode enfantine, comprendre les interactions des enfants avec leur propre culture, et envisager les perspectives que cette approche pourrait apporter aux jeunes en termes d’éducation et de citoyenneté.
« La Mongolie ne disparaîtra que si [le deel] disparaît du monde »
Authors: Saunier Isaline
Published: April 2024

En Mongolie, les vêtements dits « traditionnels », qu’ils soient reconnus comme anciens, ethniques ou contemporains, constituent l’un des marqueurs identitaires les plus visibles. L’intérêt des élites politiques et des institutions scientifiques et culturelles pour le deel, vêtement « traditionnel » principal des Mongols, notamment à travers les recherches historiques et les découvertes archéologiques, se développe depuis plusieurs décennies en lien avec les enjeux et les autorités politiques. Ce contexte favorise l’émergence de plusieurs festivals et défilés dédiés à cet objet vestimentaire devenu une référence en raison du sentiment de fierté nationale qu’il suscite. Je propose dans cet article d’interroger la place du vêtement, en particulier du deel, et des processus de patrimonialisation vestimentaire sous-jacents et de déterminer les « usages du passé » déployés dans un contexte mongol. En se basant sur une méthodologie ethnographique et des données récoltées entre 2015 et 2019, l’objet de cet article est de s’intéresser non seulement au patrimoine vestimentaire, mais aussi aux acteurs au cœur de la construction identitaire : comment les élites politiques, culturelles et scientifiques utilisent-elles du deel pour actualiser le « roman national » ?
L’étiquetage patrimonial des marques de mode
Authors: Courbières Caroline
Published: April 2024

Si les archives d’une marque de mode sont méthodiquement conservées en vue de préserver le témoignage de son activité passée, elles se retrouvent aujourd’hui l’objet privilégié d’une médiatisation plurielle qui vise à accroître et légitimer la valeur d’une maison de couture ou de prêt-à-porter. L’étiquetage patrimonial qu’elles assurent consiste tout d’abord à faire rayonner la griffe par leur monstration et leur mise en récit, notamment sur le support numérique. Ce phénomène de labellisation se réalise ensuite à travers les lieux physiques qui matérialisent l’identité de la marque et inscrivent son caractère historique dans l’espace public. Il se poursuit enfin dans le rôle que peuvent jouer les archives dans la réactualisation des valeurs associées à la marque. À la fois sources d’inspiration créative et ressources pour le marché du luxe de seconde main, ces objets déploient leur dimension symbolique tout en manifestant leur haute valeur marchande.
Croquis et photographies de la maison Balmain : quels enjeux patrimoniaux ?
Authors: Guillon Julia
Published: April 2024

Cette contribution propose de réévaluer l’importance du patrimoine de mode que constituent les fonds de croquis et de photographies, ces fonds « connexes » et complémentaires aux vêtements et accessoires, dans le contexte spécifique d’une maison de luxe, la maison Balmain. Ces fonds restent à ce jour mal connus du public et sous-exploités dans les études ou expositions, contrairement aux collections de vêtements et d’accessoires qui paradoxalement se limitent souvent, tout au plus, à quelques centaines de pièces. Mieux conservés que les vêtements, ils représentent des milliers, voire des dizaines de milliers d’images. Leur diffusion est d’ailleurs facilitée depuis une dizaine d’années par les chantiers de numérisation. Nous souhaitons ici analyser l’histoire de la conservation de ces ensembles au sein de la maison Balmain, souligner les spécificités de ces archives, et en présenter les usages possibles. Nous montrons combien leur valorisation est un enjeu crucial pour la création, la communication institutionnelle ou le marketing tout en contribuant à réécrire l’histoire de la marque.
Des trésors personnels
Authors: Marcia Élise
Published: April 2024

Le costume d’Arlésienne fait figure d’emblème régional en pays d’Arles. Les femmes qui le revêtent restaurent, conservent et portent des pièces parfois très anciennes, tout en faisant face à un terrible paradoxe : les choisir, c’est aussi en accélérer la destruction et rendre impossible leur transmission à des générations futures. En explorant les armoires des Arlésiennes, il est possible de recueillir le parcours de certains de ces « trésors », et d’entrevoir le lien qui les unit à leur propriétaire. Pour décrire leurs costumes, les Arlésiennes mobilisent sur un même plan leur valeur historique (la connaissance de la trajectoire de l’objet pris comme témoignage du passé), relationnelle (l’objet contenant les traces d’une relation avec les donataires ou les aïeules), ou personnelle (l’objet évoquant les goûts, le parcours et les qualités de l’Arlésienne qui le possède). S’intéresser aux récits qui entourent le costume du pays d’Arles permet alors d’entrevoir les tensions autour de la conservation et du port de ce vêtement singulier, qui, pour rester « vivant » et « authentique », doit pouvoir puiser dans les registres à la fois de l’histoire personnelle, familiale et régionale.
1874-1875 : la naissance d’une conscience patrimoniale de la mode en France
Authors: Bass-Krueger Maude
Published: April 2024

La première exposition sur l'histoire du costume, le « Musée historique du costume », fut inaugurée en France en 1874. Un an plus tard, l'historien et archéologue Jules Quicherat (1814-1882) publia le premier ouvrage de vulgarisation sur l'histoire du costume français, l'Histoire du costume en France depuis les temps reculés jusqu'à nos jours (Hachette, 1875). L'exposition et le livre ont connu un immense succès. Cet article cherche à comprendre l'intérêt naissant pour la culture matérielle de la mode qu'ils ont tous deux révélé. En examinant de plus près la manière dont les organisateurs choisirent de présenter les objets dans le « Musée historique du costume », ainsi que la manière dont ils incitèrent le visiteur à voir ce qui se trouvait dans l'exposition, on découvre le tout premier cadre institutionnel pour l'interaction du public avec les objets historiques de la mode. L'analyse de l'Histoire du costume et, en particulier, l'examen attentif de la méthode utilisée par Quicherat montrent comment ce dernier a réussi à intégrer les objets de mode en tant que sources dans un récit historique plus large.
Une entreprise ordinaire de confection au temps de l’essor du prêt-à-porter
Authors: Assegond Céline , Assegond Christèle
Published: April 2024

Restées dans l’ombre des grandes maisons de couture, les petites entreprises de confection ont fermé dans l’indifférence à la fin du xxe siècle. Elles ont pourtant contribué par leur activité et leur maillage du territoire à deux mouvements qui constituent des tournants dans l’histoire de la mode et qui continuent de marquer le secteur : l’essor d’un prêt-à-porter accessible au plus grand nombre et la vente par correspondance. Elles ont aussi accompagné et popularisé plusieurs innovations majeures tant dans l’usage de nouvelles matières textiles que dans les techniques de confection des modèles. À partir de l’exemple de l’une de ces entreprises de province, la société Robinet à Vierzon, nous montrons l’urgence qu’il y a à identifier, sauvegarder et partager ce patrimoine modeste dont une partie a déjà été détruite, ainsi que l’intérêt scientifique des matériaux collectés. Témoignages filmés et documents rassemblés constituent une archive qui contribue à documenter tant l’histoire des entreprises de mode que celle de la distribution du prêt-à-porter.
A Câmara de Educação Básica do Conselho Nacional de Educação (1996-2002): formação, produção acadêmica e cultura política
Authors: Negreiros Heitor Lopes , Ferreira Neto Amarílio , Santos Wagner dos
Published: April 2024

Este artigo adota como fontes os Currículos Lattes dos conselheiros da Câmara de Educação Básica do Conselho Nacional de Educação do período de 1996 a 2002, a busca geral no Google e suas produções acadêmicas. Tem por objetivo analisar a influência das trajetórias formativas e seus desdobramentos na produção acadêmica dos conselheiros da Câmara de Educação Básica do Conselho Nacional de educação (1996-2002) para a constituição de uma cultura político-educacional brasileira no contexto de projetos educacionais em disputa. Como fundamentação teórico-metodológica, assume a análise crítico-documental e o paradigma indiciário. Os resultados evidenciam que os conselheiros que tinham consistente produção acadêmica educacional configuravam-se como relevantes na instituição (1996-2002) e na continuidade (a partir de 2003) da cultura político-educacional e aqueles que não tinham produção expressiva a influenciavam a partir das suas trajetórias e das suas redes de sociabilidade. Concluímos que existe uma influência das trajetórias formativas no estabelecimento da cultura político-educacional daquele período e seus desdobramentos na produção acadêmica, que se constituía como elemento escriturístico capaz de influenciar a cultura político-educacional no momento presente e sua continuidade. Além disso, essa produção indicia as características políticas do país e as políticas educacionais que estavam em evidência, as tensões, disputas e negociações para a constituição de diferentes projetos educacionais, como também, instrumento de amadurecimento da cultura político-educacional, assim como agente disseminador desta nos projetos educacionais em disputa.
Norte e Sul: as estratégias educacionais do Ensino Médio no estado do Amazonas e no estado do Paraná
Authors: Costa Rúbia Darivanda da Silva , Malacarne Vilmar
Published: April 2024

O presente estudo apresenta análises dos Planos Educacionais do Estado (PEE) do Amazonas e do Paraná, a fim de conhecermos a realidade das estratégias recomendadas para a Educação Básica nesses dois estados brasileiros. A análise desses documentos promoveu o conhecimento acerca das demandas do processo educacional nesses estados, bem como a compreensão das metas e estratégias contidas nos planos estaduais que regem a educação. Embora os PEE apresentem vários pontos em comum, no que tange às estratégias para o fortalecimento do Ensino Médio, esses planos possuem também diferenças que refletem as particularidades do sistema educacional, territorial, econômico e regional de cada estado. Apesar dos esforços dispensados para o planejamento e elaboração de estratégias para alcançar as metas, tanto a nível nacional quanto estadual, o Relatório do 3º Ciclo de Monitoramento das Metas do Plano Nacional de Educação (PNE), evidencia um retrocesso significativo na educação brasileira, visto que não somente a meta proposta para o Ensino Médio não foi alcançada, como também, a maioria das metas estimadas para outros níveis e modalidade de ensino. Por fim, percebemos que este estudo ressalta diversos fatores que podem influenciar no processo educacional, e que para atingir as metas indicadas nos PEEs é importante que as estratégias estejam de acordo com a realidade regional e local, assim como com o contexto em que os estudantes estão inseridos.
DESAFIOS E REFLEXÕES ACERCA DA ESCASSEZ DO ENSINO DE EDUCAÇÃO AMBIENTAL NA EDUCAÇÃO INFANTIL
Authors: Da Silva Borgato Franciele , Mazzi Julia Maria , De Oliveira Scaramussi Gabriela
Published: April 2024

Este artigo foi elaborado como parte integrante dos requisitos da disciplina de Educação Ambiental do curso de pedagogia no Centro Universitário do Sagrado Coração. Diante da escassez do ensino ambiental em instituições de educação infantil, abordamos a necessidade de incorporar um ensino efetivo de educação ambiental para os alunos nessa fase crucial, onde se iniciam as bases de valores que os acompanharão ao longo da vida. O objetivo principal é sensibilizar e conscientizar as crianças de forma lúdica em relação ao meio ambiente. Portanto, foi realizado uma oficina com a temática “pequenos guardiões do meio ambiente”. Essa pesquisa-ação proporcionou uma experiência prática na escola, envolvendo a mobilização e apoio significativo da maioria dos funcionários. Os resultados esperados foram alcançados com sucesso, evidenciados pelo interesse e participação ativa dos alunos e de toda comunidade escolar nas práticas propostas sobre a consciência ambiental.
SOROPREVALÊNCIA DO VÍRUS LINFOTRÓPICO DE CÉLULAS T HUMANAS (HTLV) SEGUNDO DADOS REGISTRADOS NO HEMOCENTRO REGIONAL DE CASCAVEL - PR
Authors: Schmidtke Livia , Selleri Rafaela , Piovan Silvano
Published: April 2024

O vírus linfotrópico de células T humano, mais conhecido como HTLV, foi isolado pela primeira vez em 1980, sendo dividido em dois grupos, HTLV I e HTLV II, os quais se diferenciam pelos linfócitos de sua preferência, CD4+ e CD8+ respectivamente. O Brasil está dentre os países que têm a maior prevalência de portadores de HTLV no mundo, por ser um vírus pouco conhecido e que não possui notificação compulsória, sua maior prevalência se dá nos bancos de sangue. Estudos mostram que há uma correlação direta entre a idade e o sexo nos casos de HTLV positivos em bancos de sangue. Diante dessa realidade, este projeto tem por objetivo estudar a soroprevalência deste vírus na região de Cascavel - PR por meio de uma pesquisa exploratória quantitativa baseada na análise estatística dos dados coletados dos doadores de sangue do Hemocentro Regional de Cascavel. Os dados que foram levados em consideração são aqueles que apresentaram sorologia positiva para o vírus HTLV I e II, coletados no Hemocentro Regional de Cascavel no período de 2012 a 2022.
The association between serum BDNF levels, BDNF polymorphisms, and tardive dyskinesia: A review of current evidence
Authors: Uludag K.
Published: April 2024

Background: Tardive Dyskinesia (TD) is a movement disorder that can be potentially permanent and is commonly found among psychiatric patients who are taking antipsychotics or lithium. Studies have investigated the association between TD and genetics, particularly the impact of Brain-Derived Neurotrophic Factor (BDNF) polymorphisms on TD occurrence and cognitive changes. Among the BDNF polymorphisms studied, Val66Met has been investigated extensively. Nevertheless, the extent to which genetic approaches can contribute to comprehending the susceptibility to TD remains uncertain.Methods: PubMed was used to search articles systematically. Twenty-seven articles published in the last ten years (2012-2022) were retrieved. Review, meta-analysis, retracted, animal studies, and comment articles were excluded. In addition, only articles in English language were included.Results: Preliminary results of the study suggest an association between TD occurrence and cognition with specific BDNF polymorphisms and serum BDNF levels.Conclusions: In conclusion, our study findings suggest a potential relationship between TD and BDNF polymorphisms as well as serum BDNF levels.
A peculiar case of neurosyphilis presenting with general paresis of the insane with concurrent untreated HIV infection
Authors: Perera O. T. D. , Ranasinghe C. K. , Wimalarathna G. K. B. M. ,  Karunarathna G. D. K. N. ,  Wijesiriwardena S. C.
Published: April 2024

General paresis of insane or dementia paralytica is a rare conventional manifestation of neurosyphilis. In the era of penicillin and HIV it is a challenge to observe and diagnose typical presentations of neurosyphilis.42-year-old single male presented with an acute behavioural disturbance with hearing voices in a background of rapidly progressing forgetfulness and functional deterioration to the extent of needing support for his activities of daily living with urine incontinence for nine months duration. His beha-vioural change had first started with distressing insomnia leading to consumption of alcohol 30 units a day. Gradually displayed disorganised and dis-inhibited behaviour with some overactivity and was treated as a mood disorder with poor response and rapid deterioration of functioning.Investigations revealed marked impairment of frontal lobe and dominant parietal lobe functions in extended cognitive assessment. Blood investigations revealed normocytic normochromic anaemia with raised inflammatory markers: CRP, ESR, CPK with normal thyroid function. Syphilis serology was positive. Subsequently the examination carried out by an eye surgeon detected ocular syphilis. CSF analysis was negative for syphilis and the changes were most likely related to the untreated HIV infection with a CD4 count of 104 cells/μL. Neuroimaging showed generalized cortical atrophy with enlarged ventricles. He was treated for neurosyphilis as well as and treatment for HIV was initiated, but there was minimal improvement.Conclusions: Neurosyphilis remains as an important aetiology to be considered in rapidly progressing dementia in young patients. Comorbid HIV infection worsens the severity and prognosis.
Psychiatry, caught in the web of the internet
Authors: Amarakoon L. , Fernando R.
Published: April 2024

No abstract available
Sialyl Lewis X Defines an Activated and Functional Regulatory T Cell Subpopulation in Mice
Authors: Ohishi Kanae , Ishikura Asaki , Nishida Shogo , Abo Hirohito , Nakatsukasa Hiroko , Kawashima Hiroto
Published: April 2024

Attempts have been made to elucidate the functional markers of regulatory T cells (Tregs), CD4+Foxp3+ T cells with an immunosuppressive function. Sialyl Lewis X (sLex), a tetrasaccharide Ag, is involved in leukocyte trafficking as selectin ligands and is a marker of highly differentiated Tregs in humans. However, the importance of sLex in murine Tregs remains unknown. In this study, we report that sLex defines the activated and functional subset of murine Tregs. The contact hypersensitivity model showed that murine Tregs strongly express sLex upon activation, accompanied by functional Treg marker elevation, such as Foxp3, CD25, CD103, CD39, and granzyme B. RNA sequencing analysis revealed sLex-positive (sLex+) Tregs expressed genes involved in Treg function at a higher level than sLex-negative (sLex−) Tregs. Using an in vitro suppression assay, we found that sLex+ Tregs could more efficiently suppress naive CD4+ T cell proliferation than sLex− Tregs. In the murine contact hypersensitivity elicitation model, the topical sLex+ Treg injection into the ears suppressed ear inflammation more efficiently than that of sLex− Tregs. Our results indicate that sLex could serve as a unique surface marker of activated and functional Tregs with immunosuppressive functions in mice.
Videostylet-guided Intubation in a Case of Huge Ranula: A Novel Technique for Paediatric Difficult Intubation
Authors: Oak Shrikanta , Yashod Shamala Dinkar , Shah Monal
Published: April 2024

A large sublingual ranula compromises the anterior pharyngeal space and thus, there is a technical difficulty in direct laryngoscopy and endotracheal intubation. Videostylet-guided intubation has the advantage to overcome this difficulty. Here, we report successful videostylet-guided intubation in a case of huge plunging intraoral ranula in a 5-year-old female child posted for surgical excision of the ranula.
Anaesthesia and Airway Challenges in Patients with Corrosive Pharyngo-oesophageal Stricture: Experience of a Tertiary Care Centre
Authors: Shah Prerana Nirav , Furia Jhanvi Sunil
Published: April 2024

Background:

Ingestion of corrosive substances causes necrosis of the tissues of the upper airway and upper gastrointestinal tract resulting not only in acute airway injuries but also long-term sequelae like strictures. Medical and surgical management of these strictures has been discussed extensively; however, there is little literature available on the anaesthetic management of pharyngo-oesophageal strictures. We hereby discuss our experience in managing these patients undergoing surgical correction.

Methods:

Out of a total of 57 cases of corrosive ingestion injuries between 2008 and 2016, medical records of 15 patients with complex pharyngeal or high oesophageal strictures undergoing surgical intervention were reviewed. The preoperative findings, the extent of airway involvement and any airway intervention done were noted. Based on the surgical intervention, patients were divided into two groups; Group A included patients undergoing repeated string dilatation and Group B included those undergoing coloplasty. Type of anaesthesia given, details of airway management, intraoperative and postoperative course and complications were noted.

Results:

Group A consisted of 10 patients who underwent endless string dilatation, and Group B consisted of five patients who underwent coloplasty. In Group A, general anaesthesia with endotracheal intubation was given to all patients except for one patient who was tracheostomised. Two patients had significant glottic narrowing and required a smaller size tube. In Group B, four out of five patients were tracheostomised, while one had a normal glottic opening. General anaesthesia with epidural analgesia was given to all patients. Severe haemodynamic changes were seen during tunnelling through the posterior mediastinum for colonic interposition. All patients were extubated on the table. None of the patients required postoperative ventilatory or inotropic support.

Conclusion:

Management of corrosive pharyngo-oesophageal strictures is challenging and requires a multidisciplinary approach. Careful assessment and management of the airway, vigilant intraoperative haemodynamic monitoring and good pain management are the key contributions of anaesthesia care.
Bronchial Injury Following a Double-lumen Endotracheal Tube Insertion – How We Managed
Authors: Ganesh Mallika , Vinod NK
Published: April 2024

Tracheobronchial injury is a known complication during a double-lumen tube intubation. There are several factors which increase the risk of such injuries, including malignancy, postirradiation and pulmonary tuberculosis. Here, we discuss a case of a female patient, diagnosed with adenocarcinoma of the lower lobe of the left lung, posted for lobectomy, who developed a left main bronchus injury during intubation with a double-lumen tube. We discuss the possible factors for the injury and how we managed it using a covered endobronchial stent.
Serum podoplanin expression and frequency of thrombosis in adult de novo acute myeloid leukemia patients: An Egyptian single center study
Authors: Azzazi Mohamed O , Moussa Mohamed , Hegab Hany M , Mohamed Eid Inas AM , Khalifa Ibtesam M
Published: April 2024

Background

Cancer-associated thrombosis although represents a significant disease worse prognosis, understanding its underlying pathophysiology remains obscure. Podoplanin and its platelet ligand C-type lectin receptor type-2 have been investigated in the past few years for their potential role as procoagulant substances as it has been shown in many studies that binding of podoplanin with platelet C-type lectin receptor type-2 results in enhancement of platelet aggregation and thrombotic insults.

Aim

In this study, serum podoplanin was measured in newly diagnosed acute myeloid leukemia (AML) patients and its relation to the incidence of thrombosis in these patients in addition to its relation to other clinical, laboratory, and prognostic outcomes.

Patients and methods

This study included 80 participants (60 newly diagnosed adult AML patients and 20 age-matched and sex-matched healthy controls). Blood counts and flow cytometry using an acute leukemia panel were performed in addition to serum podoplanin, and cytogenetic studies including conventional karyotyping and fluorescence in-situ hybridization were performed to determine the risk group. The clinical status of the patients, particularly the incidence of thrombotic events in the following 6 months, as well as the D28 outcome and 6-month survival, were determined and reported.

Results

Serum podoplanin was highly expressed in AML patients compared with control samples, with a highly significant difference (P=0.001). There was a significant inverse relation between serum podoplanin level, hemoglobin level, and white blood cell count (P=0.006 and 0.036, respectively). Those with thrombotic events during the course of the disease did not show statistically significant results when compared with the control group with regard to serum podoplanin levels (P=0.546).

Conclusion

Serum podoplanin was much higher in AML patients than in the control group (P=0.000), and it was inversely related to platelet level (P=0.036) and total leukocyte count (P=0.006). However, there was no statistically significant link between podoplanin level and the incidence of thrombotic events (P=0.546).
Prevalence and predictors of pulmonary hypertension in patients with myeloproliferative neoplasms: single-center study
Authors: Eid Mohamed , Kasem Ali M , Kamal Yasser M , Hamdy Mahmoud , Gaber Mahmoud
Published: April 2024

Background

Pulmonary hypertension is a major complication of several hematologic disorders including myeloproliferative neoplasms (MPNs). Despite the potential significance of PH to the management and prognosis of MPN, accurate estimates of its prevalence in MPNs and risk factors for the condition are poorly established.

Aim

To determine the prevalence of pulmonary hypertension in patients with MPNs at Sohag University Hospital and to analyze data of those patients to find predictors of pulmonary hypertension in our patients.

Patients and methods

A total of 120 patients were diagnosed with MPNs according to the revised 2016 WHO diagnostic criteria who attended the Outpatient Hematology Clinic at Sohag University Hospital in the period from April 2021 to October 2022. Systolic pulmonary artery pressure (SPAP) by using Transthoracic echocardiography (TTE) is determined in all MPNs patients enrolled in our study.

Results

The overall prevalence of PH in MPN patients was found to be 26.7%. We found a significant relationship between old age, long MPN duration since diagnosis, presence of PMF, anemia, leukocytosis, hyperuricemia, and occurrence of PH.

Conclusion

The prevalence of PH in patients with MPNs was 26.7%. According to MPNs subtypes, the highest PH prevalence was in PMF patients. Our findings suggest that old age, long MPNs duration since diagnosis, presence of PMF, and hyperuricemia are valuable for predicting PH occurrence in patients with MPNs.
Serum neutrophil gelatinase-associated lipocalin as promising diagnostic marker and a predictor of activity of ulcerative colitis patients: single center study
Authors: Elshereef Hala K , Helbawi Fatma M , Mahmoud Mohamed E , Abdelwahab Hossam M
Published: April 2024

Objective

The study aimed to detect the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) in ulcerative colitis (UC) patients, and to evaluate the relation between its value and the clinical activity of the disease.

Background

Inflammatory bowel disease including UC is chronic inflammatory gastrointestinal disease characterized by remissions and exacerbations and needs invasive diagnosis. Serum NGAL is type of protein its expression is increased in inflamed intestine, and released from activated neutrophils.

Patients and methods

The study was performed on 75 patients with UC diagnosed by laboratory investigations including erythrocyte sedimentation rate, C-reactive protein, and complete blood count, lower endoscopy, histopathological examination, and activity according to Mayo score was recorded. Also 30 healthy control age sex matched, both groups subjected to measurement of serum NGAL.

Results

There was highly significant elevation of serum NGAL in UC patients compared with healthy control with P value less than 0.001, moreover serum NGAL was positively correlated with clinical activity of the disease as recorded by Mayo score. The study show cut off value of NGAL more than 74 ng/ml with sensitivity 96% and specificity 66.7%.

Conclusion

Serum NGAL can be used as noninvasive diagnostic marker of UC and corresponds to clinical and endoscopic activity of the disease.
Plant Decellularization by Chemical and Physical Methods for Regenerative Medicine: A Review Article
Authors: Rabbani Mohsen , Salehani Alireza A. , Farnaghi Mohammadhasan , Moshtaghi Maryam
Published: April 2024

Fabricating three-dimensional (3D) scaffolds is attractive due to various advantages for tissue engineering, such as cell migration, proliferation, and adhesion. Since cell growth depends on transmitting nutrients and cell residues, naturally vascularized scaffolds are superior for tissue engineering. Vascular passages help the inflow and outflow of liquids, nutrients, and waste disposal from the scaffold and cell growth. Porous scaffolds can be prepared by plant tissue decellularization which allows for the cultivation of various cell lines depending on the intended application. To this end, researchers decellularize plant tissues by specific chemical and physical methods. Researchers use plant parts depending on their needs, for example, decellularizing the leaves, stems, and fruits. Plant tissue scaffolds are advantageous for regenerative medicine, wound healing, and bioprinting. Studies have examined various plants such as vegetables and fruits such as orchid, parsley, spinach, celery, carrot, and apple using various materials and techniques such as sodium dodecyl sulfate, Triton X-100, peracetic acid, deoxyribonuclease, and ribonuclease with varying percentages, as well as mechanical and physical techniques like freeze–thaw cycles. The process of data selection, retrieval, and extraction in this review relied on scholarly journal publications and other relevant papers related to the subject of decellularization, with a specific emphasis on plant-based research. The obtained results indicate that, owing to the cellulosic structure and vascular nature of the decellularized plants and their favorable hydrophilic and biological properties, they have the potential to serve as biological materials and natural scaffolds for the development of 3D-printing inks and scaffolds for tissue engineering.
Effectiveness of Reinforced Oral Health Education on the Oral Hygiene Status of 9–12-year-old Primary Schoolchildren: A Follow-up Study
Authors: Pandya Sajankumar R. , Hegde Vijaya
Published: April 2024

Background:

In the society, school is a significant formal unit where implementation of health programs can help in improving children’s educational and health status. The impact of repeated reinforcement of oral health education on schoolchildren can provide substantial evidence for policymaker. Thus, a follow-up study was conducted to assess the effectiveness of reinforced oral health education on the oral hygiene status of primary schoolchildren.

Materials and Methods:

The present follow-up study was conducted among primary schoolchildren in Mangalore, Karnataka, India for a duration of 8 months from January 2015 to August 2015. Multistage sampling method was used. The primary investigator collected data using an Oral Hygiene Index-Simplified (OHI-S). Impact of oral health education repeated reinforcement on retention of proper behavior among schoolchildren toward oral health and oral hygiene practices. Friedman test for comparison among different time interval. Wilcoxon signed-rank test was used for intragroup comparison.

Results:

Nearly 83.3% of study subjects were using toothbrush and toothpaste to clean their teeth. About 88.1% of study subjects had never visited a dentist ever. A statistically significant difference was observed at three different time intervals for debris, calculus, and OHI-S score (P < 0.05).

Discussion:

On intragroup comparison between three time intervals, study results reported a significant improvement in oral hygiene at 4 months and 8 months (P < 0.01). It shows that reinforcement of oral health education at regular time intervals had a significant positive impact on oral hygiene status.
Social, behavioral and environmental determinants of vector-borne diseases: A narrative review of evidence and implications for integrated control approaches
Authors: Alqassim Ahmad Y
Published: April 2024

Vector-borne diseases exert immense health burdens worldwide. Malaria alone causes over 200 million cases and 600,000 deaths annually. Transmission involves complex drivers requiring examination beyond entomological factors. A systematic literature search across databases identified relevant studies on vector-borne disease determinants published in the last two decades, with priority given to rigorous designs like longitudinal analyses, reviews, and meta-analyses from diverse epidemic regions, allowing narrative synthesis of key determinants, relationships, and gaps. This narrative review synthesizes evidence on social, behavioral, and environmental determinants of major vector-borne disease risks over the past decade. Lower education, poverty, unplanned urbanization, gender inequities, inadequate water and waste management, climate variations, and land-use changes stood out as key determinants. However, significant knowledge gaps remain around quantifying precise threshold effects and impacts of tailored interventions across contexts. A social-ecological perspective recognizing interdependencies between determinants should frame integrated control programs. Multicomponent strategies addressing environmental modifications, protective measures, behavioral motivators, and infrastructure alongside governance and community engagement require implementation research and impact evaluation. Overall, this review highlights priority areas for advancing evidence-based vector control through contextualized, determinant-targeted policies and interventions. Further research incorporating modeling, trials, and cost-effectiveness analyses is critical to validate approaches that address influential drivers, leverage motivators, and reduce the global burden.
Profiling the socioeconomic characteristics, dietary intake, and health status of Korean older adults for nutrition plan customization: a comparison of principal component, factor, and cluster analyses
Authors: Woo Kyungsook , Kim Kirang
Published: April 2024

OBJECTIVES: This study was conducted to establish profiles of socioeconomic characteristics, dietary intake, and health status among Korean older adults by employing 3 multivariate analysis techniques.METHODS: Data were obtained from 1,352 adults aged 65 years and older who participated in the 2019 Korea National Health and Nutrition Examination Survey. Principal component analysis (PCA), factor analysis (FA), and cluster analysis (CA) were utilized for profiling, with data preprocessing undertaken to facilitate these approaches.RESULTS: PCA, FA, and CA yielded similar results, reflecting the high common variance among the variables. PCA identified 4 components, accounting for 71.6% of the accumulated variance. FA revealed 5 factors, displaying a Kaiser-Meyer-Olkin value of 0.51 and explaining 74.3% of the total variance. Finally, CA grouped the participants into 4 clusters (R2=0.465). Both PCA and FA identified dietary intake (energy, protein, carbohydrate, etc.), social support from family (incorporating family structure, number of family numbers, and engagement in social eating), and health status (encompassing oral, physical, and subjective health) as key factors. CA classified Korean older adults into 4 distinct typologies, with significant differences observed in dietary intake, health status, and household income (p<0.01).CONCLUSIONS: The study utilized PCA, FA, and CA to analyze profiling domains and derive characteristics of older adults in Korea, followed by a comparison of the results. The variables defining the clusters in CA were consistent with those identified by PCA and FA.
Assessing the Impact of Rubberized Asphalt on Reducing Hip Fracture
Risk in Elderly Populations Using Human Body Models
Authors: Sahandifar Pooya , Wallqvist Viveca , Kleiven Svein
Published: April 2024

Compared to other age groups, older adults are at more significant risk of hip
fracture when they fall. In addition to the higher risk of falls for the
elderly, fear of falls can reduce this population’s outdoor activity. Various
preventive solutions have been proposed to reduce the risk of hip fractures
ranging from wearable hip protectors to indoor flooring systems. A previously
developed rubberized asphalt mixture demonstrated the potential to reduce the
risk of head injury. In the current study, the capability of the rubberized
asphalt sample was evaluated for the risk of hip fracture for an average elderly
male and an average elderly female. A previously developed human body model was
positioned in a fall configuration that would give the highest impact forces
toward regular asphalt. Three different rubber contents with 14, 28, 33 weight
percent (% wt.) were implemented as the ground alongside one regular
non-rubberized (0%) asphalt mixture, one baseline, and one extra-compliant
playground rubber-composite material. The whole-body model was simulated to fall
on the rubberized asphalt mixtures with an initial vertical velocity of 3 m/s
with a 10° trunk angle and +10° anterior pelvis rotation. The impact forces were
measured on the femoral head, and a previously developed hip fracture risk
function was used to compare the rubberized asphalt mixtures. It was found that
the rubberized asphalt mixture with 33% wt. rubber can reduce the impact forces
up to 10% for the elderly male and female model compared to regular asphalt. The
impact forces were most reduced for the extra-compliant playground material,
with a 23% reduction for the female model. The risk of injury for the asphalt
mixture with 33% wt. rubber was reduced up to 18% for elderly females and 20 for
elderly males, compared to regular asphalt. The extra-compliant playground
material had the most reduction of hip fracture risk for both sexes, 39 and 43%
for elderly females and males, respectively.
Prognostic significance of tumor budding, desmoplastic reaction, and lymphocytic infiltration in patients with gastric adenocarcinoma
Authors: Yavuz Aysen , Simsek Kubra , Alpsoy Anil , Altunay Busra , Gedik Elif Ocak , Unal Betul , Bassorgun Cumhur Ibrahim , Tatli Ali Murat , Elpek Gulsum Ozlem
Published: April 2024

BACKGROUND

Recent studies have shown that the tumor microenvironment significantly influences the behavior of solid tumors. In this context, Accumulated data suggests that pathological evaluation of tumor budding (TB), desmoplastic reaction (DR), and tumor-infiltrating lymphocytes (TILs) may be crucial in determining tumor behavior in the gastrointestinal tract. Regarding gastric adenocarcinoma (GAC), although some results suggest that TB and TILs may be effective in determining the course of the disease, the data do not agree. Moreover, very few studies have investigated the relationship between DR and survival. At present, the associations between tumor TB, DR and TILs in GAC patients have not been determined.

AIM

To establish the relationships between TB, DR, and TILs in patients with GAC and to assess their influence on prognosis.

METHODS

Our study group comprised 130 patients diagnosed with GAC. The definition of TB was established based on the International TB Consensus Conference. The DR was categorized into three groups according to the level of tumor stroma maturation. The assessment of TILs was conducted using a semiquantitative approach, employing a cutoff value of 5%. The statistical analysis of the whole group and 100 patients with an intestinal subtype of GAC was performed using SPSS version 27.

RESULTS

A significant correlation between peritumoral budding (PTB) and intratumoral budding (ITB) was noted (r = 0.943). Tumors with high PTBs and ITBs had a greater incidence of immature DRs and low TILs (P < 0.01). PTB and ITB were associated with histological subtype, lymph node metastasis (LNM), and stage (P < 0.01). ITB, PTB, LNM, DR, and stage were significant risk factors associated with poor prognosis. The multivariate Cox regression analysis identified ITB, PTB, and LNM as independent prognostic variables (P < 0.05). In intestinal-type adenocarcinomas, a positive correlation between PTB and ITB was noted (r = 0.972). While univariate analysis revealed that LNM, stage, PTB, ITB, and DR were strong parameters for predicting survival (P < 0.05), only PTB and ITB were found to be independent prognostic factors (P < 0.001).

CONCLUSION

TB may be a potential prognostic marker in GAC. However, further studies are needed to delineate its role in pathology reporting protocols and the predictive effects of DR and TILs.
Sepsis during short bowel syndrome hospitalizations: Identifying trends, disparities, and clinical outcomes in the United States
Authors: Dahiya Dushyant Singh , Wachala Jennifer , Solanki Shantanu , Solanki Dhanshree , Kichloo Asim , Holcomb Samantha , Mansuri Uvesh , Haq Khwaja Saad , Ali Hassam , Gangwani Manesh Kumar , Shah Yash R , Varghese Teresa , Khan Hafiz Muzaffar Akbar , Horslen Simon Peter , Schiano Thomas D , Jafri Syed-Mohammed
Published: April 2024

BACKGROUND

Short bowel syndrome (SBS) hospitalizations are often complicated with sepsis. There is a significant paucity of data on adult SBS hospitalizations in the United States and across the globe.

AIM

To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United States.

METHODS

The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between 2005-2014. The study cohort was further divided based on the presence or absence of sepsis. Trends were identified, and hospitalization characteristics and clinical outcomes were compared. Predictors of mortality for SBS hospitalizations complicated with sepsis were assessed.

RESULTS

Of 247097 SBS hospitalizations, 21.7% were complicated by sepsis. Septic SBS hospitalizations had a rising trend of hospitalizations from 20.8% in 2005 to 23.5% in 2014 (P trend < 0.0001). Compared to non-septic SBS hospitalizations, septic SBS hospitalizations had a higher proportion of males (32.8% vs 29.3%, P < 0.0001), patients in the 35-49 (45.9% vs 42.5%, P < 0.0001) and 50-64 (32.1% vs 31.1%, P < 0.0001) age groups, and ethnic minorities, i.e. , Blacks (12.4% vs 11.3%, P < 0.0001) and Hispanics (6.7% vs 5.5%, P < 0.0001). Furthermore, septic SBS hospitalizations had a higher proportion of patients with intestinal transplantation (0.33% vs 0.22%, P < 0.0001), inpatient mortality (8.5% vs 1.4%, P < 0.0001), and mean length of stay (16.1 d vs 7.7 d, P < 0.0001) compared to the non-sepsis cohort. A younger age, female gender, White race, and presence of comorbidities such as anemia and depression were identified to be independent predictors of inpatient mortality for septic SBS hospitalizations.

CONCLUSION

Septic SBS hospitalizations had a rising trend between 2005-2014 and were associated with higher inpatient mortality compared to non-septic SBS hospitalizations.
Resale price maintenance: by object infringements and per se infringements – mind the gap!
Authors: Hutton Christopher , Levy Victor , Peacock Christopher , Chellet Pierre
Published: April 2024

On 29 June 2023, the Court of Justice of the European Union issued a preliminary judgment with respect to the status of resale price maintenance under EU competition law (Case C-211/22 Super Bock EU:C:2023:529). It clarified the notion of resale price maintenance and provided guidance as to the treatment of such conduct as a hardcore restriction and a potential by object restriction of competition under Article 101 TFEU. The purpose of this article is to assess how competition authorities and companies may use such recent case law to better understand resale price maintenance. We argue that, far from a per se infringement, the characterization of vertical price fixing as a restriction of competition ‘by object’ requires a detailed assessment of the context. In some cases (such as a risk of free riding, or protection of brand image), context may indeed cast doubt as to the alleged anticompetitive nature of such conduct.