bluuebunny/crossref_metadata_2025 huggingface dataset:
Electric Vehicles as a Flexibility Provider: Optimal Charging Schedules to Improve the Quality of Charging Service
Authors: Rauma Kalle , Funke Alexander , Simolin Toni , Järventausta Pertti , Rehtanz Christian
Published: June 2021

The sub-aggregation of electric vehicles provides significant potential to power systems in the form of ancillary services. This means with smart charging it is possible to shift loads from peak to off-peak hours. For the flexibility from privately owned electric vehicles to be offered to the electricity market, customer participation is crucial; however, the impacts of sub-aggregation on customers have not been studied thoroughly. In this paper, charging data covering over 80,000 real-world charging sessions from various commercial charging sites are introduced and the charging characteristics are analyzed. Importantly, a method for finding an optimal pattern for load reduction with the least impact on customers is presented. We suggest an optimal schedule for load reduction from the customer viewpoint at different types of charging sites, including public car parks, offices, residential sites, and shopping centers. The findings indicate that residential and office charging sites offer the greatest potential for load reduction with the least impact on customers. The most flexibility is available during peak charging hours, which on average are at 08:00 at car parks, 07:30 at office sites, 19:00 at residential sites, and 10:00 at shopping centers.
Nano-Enhanced Phase Change Materials in Latent Heat Thermal Energy Storage Systems: A Review
Authors: Tofani Kassianne , Tiari Saeed
Published: June 2021

Latent heat thermal energy storage systems (LHTES) are useful for solar energy storage and many other applications, but there is an issue with phase change materials (PCMs) having low thermal conductivity. This can be enhanced with fins, metal foam, heat pipes, multiple PCMs, and nanoparticles (NPs). This paper reviews nano-enhanced PCM (NePCM) alone and with additional enhancements. Low, middle, and high temperature PCM are classified, and the achievements and limitations of works are assessed. The review is categorized based upon enhancements: solely NPs, NPs and fins, NPs and heat pipes, NPs with highly conductive porous materials, NPs and multiple PCMs, and nano-encapsulated PCMs. Both experimental and numerical methods are considered, focusing on how well NPs enhanced the system. Generally, NPs have been proven to enhance PCM, with some types more effective than others. Middle and high temperatures are lacking compared to low temperature, as well as combined enhancement studies. Al2O3, copper, and carbon are some of the most studied NP materials, and paraffin PCM is the most common by far. Some studies found NPs to be insignificant in comparison to other enhancements, but many others found them to be beneficial. This article also suggests future work for NePCM and LHTES systems.
Heat Integration of an Industrial Unit for the Ethylbenzene Production
Authors: Ulyev Leonid M. , Kanischev Maksim V. , Chibisov Roman E. , Vasilyev Mikhail A.
Published: June 2021

This paper presents both the results of a study of the existing heat exchanger network (HEN) of an industrial unit for ethylbenzene (EB) production by the alkylation of benzene with ethylene, and an analysis of four different HEN retrofit projects carried out using process integration methods. The project of modernization of HEN was carried out using classical methods of Pinch analysis. For this case, the value of ΔTmin is determined, which is limited by the technological conditions of the process. Additionally, two different heat pump (HP) integration options and the joint retrofit Pinch project with HP integration are under consideration. The economic analysis of each of the projects was carried out. It is shown that the best results will be obtained when implementing the joint project. As a result, steam consumption will be reduced by 34% and carbon dioxide emissions will be decreased by the same amount.
Long Non-Coding RNA and Its Regulatory Network Response to Cold Stress in Eucalyptus urophylla S.T.Blake
Authors: Chen Hao , Li Jiang , Qiu Bingfa , Zhao Yingwei , Liu Zhao , Yang Jun , Kang Xiangyang
Published: June 2021

Long non-coding RNA (lncRNA) plays an important regulatory role in plant growth and development, but its systematic identification and analysis in Eucalyptus has not yet been reported. Cold stress has a huge impact on the survival and yield of Eucalyptus seedlings, but the regulatory mechanism of lncRNA in Eucalyptus in response to cold stress is still unclear. In this study, the transcriptomes of young leaves of Eucalyptus urophylla S.T.Blake under low-temperature treatment and restoration were analyzed by RNA-seq. A total of 11,394 lncRNAs and 46,276 mRNAs were identified, of which 300 were differentially expressed lncRNAs (DE_lncRNAs) and 5606 were differentially expressed target genes of lncRNAs under cold stress, with the total number of target genes of DE_lncRNAs being 1681. A total of 677 differentially expressed transcription factors (TFs) were also identified, mainly including ERF, MYB and the NAC transcription factor family. Gene ontology (GO) analysis of the differentially expressed genes (DEGs) and target genes of DE_lncRNAs was mostly related to the response to cold stress and external stimuli. Furthermore, lncRNA–miRNA–mRNA regulatory networks were constructed, and 22 DE_lncRNAs were predicted to be targets or targeting mimics of 20 miRNAs. A qRT-PCR was used to verify the relative expression of genes in the regulatory EuGBF3-EUC_00002677-MSTRG.7690 network, and it matched the transcriptome data, indicating that it may play an important role in the response to cold stress in E. urophylla. This study provides a new insight into lncRNA and its regulatory network under abiotic stress, especially cold stress in E. urophylla.
Illegal Logging and the Productivity Trap of Timber Production in Mexico
Authors: Torres-Rojo Juan Manuel
Published: June 2021

This paper uses two approaches to estimate illegal volumes and provides arguments to show that timber production in Mexico is largely defined by the presence of significant volumes of illegal logging, which supply the market with a volume equivalent to that of the legal harvest. Estimated illegal volumes are closely linked to the growth rate of the construction and manufacturing sectors, which suggests these sectors trigger demand for illegal volumes, while a lower supply of illegal volumes is kept for making rustic furniture and wooden handicrafts. Illegal logging reinforces the productivity trap through several mechanisms throughout the value chain, from timber production to sawn wood retailing. These mechanisms, in conjunction with certain features of the domestic sawn wood market, contribute to keeping the forest sector in a productivity trap. Illegal logging is a complex socio-environmental problem, which requires the participation of society as a whole to reverse the effects of this activity in every component of the forest value chain.
Drought Affected Ecosystem Water Use Efficiency of a Natural Oak Forest in Central China
Authors: Niu Xiaodong , Liu Shirong
Published: June 2021

Global climate models project more frequent drought events in Central China. However, the effect of seasonal drought on ecosystem water use efficiency (WUE) and water regulation strategy in Central China’s natural forests is poorly understood. This study investigated variations in WUE associated with drought in a natural oak (Quercus aliena) forest in Central China from 2017 to 2020 at several timescales based on continuous CO2 and water vapor flux measurements. Results showed that the 4-year mean gross ecosystem production (GEP), evapotranspiration (ET) and WUE of the natural oak forest was 1613.2 ± 116 g Cm−2, 637.8 ± 163.3 mm and 2.6 ± 0.68 g Ckg−1 H2O, with a coefficient of variation (CV) of 7.2%, 25.6% and 26.4%, respectively. The inter-annual variation in WUE was large, primarily due to the variation in ET caused by seasonal drought. Drought increased WUE distinctly in summer and decreased it slightly in autumn. During summer drought, surface conductance (gs) usually decreased with an increase in VPD, but the ratios of stomatal sensitivity (m) and reference conductance (gsref) were 0.21 and 0.3 molm−2s−1ln(kPa)−1 in the summer of 2019 and 2020. Strong drought can also affect ecosystem WUE and water regulation strategy in the next year. Decrease in precipitation in spring increased annual WUE. These results suggested that drought in different seasons had different effects on ecosystem WUE. Overall, our findings suggest that the natural oak forest did not reduce GEP by increasing WUE (i.e., reducing ET) under spring and summer drought, which could be due to its typical anisohydric characteristics, although it can also reduce stomatal opening during long-term drought.
High-Efficiency Can Be Achieved for Non-Uniformly Flexible Pitching Hydrofoils via Tailored Collective Interactions
Authors: Kurt Melike , Mivehchi Amin , Moored Keith
Published: June 2021

New experiments examine the interactions between a pair of three-dimensional (AR = 2) non-uniformly flexible pitching hydrofoils through force and efficiency measurements. It is discovered that the collective efficiency is improved when the follower foil has a nearly out-of-phase synchronization with the leader and is located directly downstream with an optimal streamwise spacing of X*=0.5. The collective efficiency is further improved when the follower operates with a nominal amplitude of motion that is 36% larger than the leader’s amplitude. A slight degradation in the collective efficiency was measured when the follower was slightly-staggered from the in-line arrangement where direct vortex impingement is expected. Operating at the optimal conditions, the measured collective efficiency and thrust are ηC=62% and CT,C=0.44, which are substantial improvements over the efficiency and thrust of ηC=29% and CT,C=0.16 of two fully-rigid foils in isolation. This demonstrates the promise of achieving high-efficiency with simple purely pitching mechanical systems and paves the way for the design of high-efficiency bio-inspired underwater vehicles.
Visual Function and Ophthalmological Findings in CHARGE Syndrome: Revision of Literature, Definition of a New Clinical Spectrum and Genotype Phenotype Correlation
Authors: Onesimo Roberta , Ricci Daniela , Agazzi Cristiana , Leone Simona , Petrianni Maria , Orazi Lorenzo , Amore Filippo , Salerni Annabella , Leoni Chiara , Chieffo Daniela , Tartaglia Marco , Mercuri Eugenio , Zampino Giuseppe
Published: June 2021

CHARGE syndrome (CS) is a rare genetic disease causing multiple anatomical defects and sensory impairment. Visual function is usually reported by caregivers and has never been described with a structured behavioral assessment. Our primary objective was to describe ocular abnormalities, visual function and genotype–ocular-phenotype correlation in CS. A prospective monocentric cohort study was performed on 14 children with CS carrying pathogenic CHD7 variants. All children underwent ophthalmological evaluation and structured behavioral assessment of visual function. The VISIOCHARGE questionnaire was administered to parents. Colobomas were present in 93% of patients. Genotype–phenotype correlation documented mitigated features in a subset of patients with intronic pathogenic variants predicted to affect transcript processing, and severe features in patients with frameshift/nonsense variants predicting protein truncation at the N-terminus. Abnormal visual function was present in all subjects, with different degrees of impairment. A significant correlation was found between visual function and age at assessment (p-value = 0.025). The present data are the first to characterize visual function in CS patients. They suggest that hypomorphic variants might be associated with milder features, and that visual function appears to be related to age. While studies with larger cohorts are required for confirmation, our data indicate that experience appears to influence everyday use of visual function more than ocular abnormalities do.
The Validity and Reliability of the Copenhagen Burnout Inventory for Examination of Burnout among Preschool Teachers in Serbia
Authors: Piperac Pavle , Todorovic Jovana , Terzic-Supic Zorica , Maksimovic Aleksandra , Karic Svetlana , Pilipovic Filip , Soldatovic Ivan
Published: June 2021

Introduction: Burnout syndrome is being increasingly recognized as a factor that affects the health status and is being examined among different professional groups. Consequently, there is a need for a reliable and valid instrument for its examination. Teachers are emerging as a professional group of interest in the area of burnout research, so the aim of this study was to assess the validity and reliability of the Serbian version of Copenhagen burnout inventory among teachers at preschool institutions in Serbia. Materials and Methods: This research was conducted as a cross-sectional study between October 2018 and April 2019 on a nationally representative sample of preschool teachers in Serbia. The internal consistency of the scale was assessed using Cronbach’s alpha, and the construct validity was examined using exploratory (EFA) and confirmatory factor analyses (CFA). Results: The average score on total burnout was 39.1 ± 17.0, while the average score per scales on the Copenhagen burnout inventory was: 41.3 ± 18.7 for personal burnout, 41.2 ± 15.9 for work-related burnout, and 34.7 ± 22.0 for client-related burnout. The Cronbach’s alpha for the entire scale was 0.936, the Cronbach’s alpha for the personal burnout scale was 0.906, and the Cronbach’s alpha for the work-related burnout scale was 0.765, while the Cronbach’s alpha for the client-related burnout scale was 0.901. The EFA for the CBI showed three factors. The factor loadings varied from 0.575 to 0.859. The three factors explained 67.17% of the variance. Conclusions: Our study showed that the three-factor Serbian version of the Copenhagen burnout inventory can be used for the assessment of burnout syndrome among teachers.
The Premium of Public Perceived Greenery: A Framework Using Multiscale GWR and Deep Learning
Authors: Zhang Yonglin , Fu Xiao , Lv Chencan , Li Shanlin
Published: June 2021

Population agglomeration and real estate development encroach on public green spaces, threatening human settlement equity and perceptual experience. Perceived greenery is a vital interface for residents to interact with the urban eco-environment. Nevertheless, the economic premiums and spatial scale of such greenery have not been fully studied because a comprehensive quantitative framework is difficult to obtain. Here, taking advantage of big geodata and deep learning to quantify public perceived greenery, we integrate a multiscale GWR (MGWR) and a hedonic price model (HPM) and propose an analytic framework to explore the premium of perceived greenery and its spatial pattern at the neighborhood scale. Our empirical study in Beijing demonstrated that (1) MGWR-based HPM can lead to good performance and increase understanding of the spatial premium effect of perceived greenery; (2) for every 1% increase in neighborhood-level perceived greenery, economic premiums increase by 4.1% (115,862 RMB) on average; and (3) the premium of perceived greenery is spatially imbalanced and linearly decreases with location, which is caused by Beijing’s monocentric development pattern. Our framework provides analytical tools for measuring and mapping the capitalization of perceived greenery. Furthermore, the empirical results can provide positive implications for establishing equitable housing policies and livable neighborhoods.
Ethnic Identity and Well-Being of Andean Indigenous People: The Effect of Individualistic and Collectivist Value Orientations
Authors: Gutiérrez-Carmona Andrés , Urzúa Alfonso , Rdz-Navarro Karina
Published: June 2021

The aim of this research was to evaluate the mediating effect of the value orientations of collectivism and individualism on the relationship between ethnic identity and well-being, the latter conceived from the worldview of Andean natives. For this purpose, under an observational and cross-sectional design, 395 Lickan-Antay adults (57% women) living in areas of indigenous development and in two cities in northern Chile were surveyed. We used the Lickan-Antay BLA32 well-being scale, a short version of the Portrait 21 Values Questionnaire to measure individualistic and collectivistic values, and an adapted version of the Ethnic Identity Scale. The results show that ethnic identity had a direct positive effect on all three dimensions of well-being (harmony with community life, ethnic harmony and harmony with nature), and total indirect effects on all five dimensions of well-being, one of them originating mainly from collectivist orientations. Individualistic orientations also showed a positive, though less intense, mediating effect on well-being. We conclude that collectivist and individualistic motivational patterns coexist in Lickan-Antay natives and explain an important part of the relationship between ethnic identity and well-being. Finally, we discuss our results and suggest replication of this study in other ethnic contexts to assess the generalizability of these findings to other native peoples of the Andean region of South America.
Promoting the Quality of Life of Elderly during the COVID-19 Pandemic
Authors: Lee Chia-Jung , Hsu Yen
Published: June 2021

This study explored the technology learning model of the elderly in a senior learning center under the impact of the COVID-19 pandemic. Many senior learning centers were closed during the pandemic, and many of them adopted the mode of online education. However, problems such as decreased motivation and a lack of peer interaction still exist. To solve these problems, this study used the easy-to-implement calligraphy AR approach and E-book approach to conduct a quasi-experiment on the elderly of a calligraphy course offered by a senior learning center. The results show a higher learning motivation among the elderly who use calligraphy AR. The learning effectiveness and technology acceptance of the elderly in the E-book learning group were higher than those in the calligraphy AR group. The elderly mentioned that the E-book learning approach is more user-friendly. In general, in the face of the COVID-19 pandemic affecting the suspension of classes in senior centers, education through the development of technology has stimulated the growth of education in advanced learning centers. Through this kind of scientific and technological learning method, it will bring a whole new experience to the elderly. It can improve the stress relief methods, mental health, and quality of life of the elderly during the COVID-19 emergency shutdown, and provide a novel calligraphy technique learning experience for the elderly. Therefore, we believe that the calligraphy AR learning approach and the calligraphy E-book learning approach are practical and may promote quality of life and mental health of the elderly during the emergency closures due to COVID-19, providing elderly attendees with a novel calligraphy technology learning experience.
Review of Workplace Based Aerosol Sampler Comparison Studies, 2004–2020
Authors: Hanlon James , Galea Karen S. , Verpaele Steven
Published: June 2021

We provide a narrative review on published peer-reviewed scientific literature reporting comparisons of personal samplers in workplace settings published between 2004 and 2020. Search terms were developed for Web of Science and PubMed bibliographic databases. The retrieved studies were then screened for relevance, with those studies meeting the inclusion criteria being taken forward to data extraction (22 studies). The inhalable fraction was the most common fraction assessed with the IOM sampler being the most studied sampler. The most common workplace environment where samplers had been compared was that where metals/metalloids were present. The requirements of EN13205 standard (Workplace exposure. Assessment of sampler performance for measurement of airborne particle concentrations) have also been considered, with these requirements not currently being met, or at least referred to, in the included published literature. A number of conclusions have been drawn from this narrative review. For studies that reported correction factors, no discernible trends could be identified. Correction factors also varied between samplers and settings, with correction factors varying from 0.67 for Button/IOM in agriculture settings to a correction factor of 4.2 for the closed face cassette/IOM samplers in aluminium smelters. The need for more detailed and informative data sharing from authors is highlighted, providing more context to both the sampling strategy and methodology, as well as the data analysis. It is recommended that the requirements of EN13205 are taken into account when designing sampler comparison studies at the workplace and that these are also reported. It is also considered that there is a need for a clear standardized workplace sampler comparison protocol to be developed, which can be used by the research and occupational hygiene community to allow more robust and transparent assessment of aerosol samplers and better-quality evidence for use by industrial hygienists, epidemiologists, and occupational safety specialists alike.
Eye-Tracking Evaluation of Exit Advance Guide Signs in Highway Tunnels in Familiar and Unfamiliar Drivers
Authors: Shang Ting , Lu Hao , Wu Peng , Wei Yi
Published: June 2021

As a component of the traffic control plan, traffic signs on highways offer drivers necessary information. Unfortunately, many signs are unfamiliar to or misunderstood by drivers, especially when lacking a setting method; this includes exit advance guide signs in tunnels. These are generally set in roadbed sections, but space limitations in tunnels dictate that they must be set differently. To evaluate the effect of the setting method, an experiment was designed and conducted, during which the eye movements of 44 drivers with different familiarity levels were tracked. Twenty-two of the drivers had not previously participated in any experiment involving exit advance guide signs in highway tunnels, while 22 of them had. Time period data were analyzed, including data from before the sign appeared, when it appeared, and when it disappeared. Based on area division and Markov theory, attributes related to gaze transition were obtained, including one- and two-step gaze transition probabilities and area gaze probabilities. The results showed that gaze transition was confirmed to be significantly different between the three periods and between the drivers. Features extracted from eye movement characteristics, gaze transition paths, and gaze areas demonstrated that visual attention is more dispersed in familiar drivers during the lane-change intention period. Therefore, signs should be placed on the left wall of the highway tunnel.
Ingestion of Nitrate and Nitrite and Risk of Stomach and Other Digestive System Cancers in the Iowa Women’s Health Study
Authors: Buller Ian D. , Patel Deven M. , Weyer Peter J. , Prizment Anna , Jones Rena R. , Ward Mary H.
Published: June 2021

Nitrate and nitrite are precursors in the endogenous formation of N-nitroso compounds (NOC) which are potent animal carcinogens for the organs of the digestive system. We evaluated dietary intakes of nitrate and nitrite, as well as nitrate ingestion from drinking water (public drinking water supplies (PWS)), in relation to the incidence (1986–2014) of cancers of the esophagus (n = 36), stomach (n = 84), small intestine (n = 32), liver (n = 31), gallbladder (n = 66), and bile duct (n = 58) in the Iowa Women’s Health Study (42,000 women aged from 50 to 75 in 1986). Dietary nitrate and nitrite were estimated using a food frequency questionnaire and a database of nitrate and nitrite levels in foods. Historical nitrate measurements from PWS were linked to the enrollment address by duration. We used Cox regression to compute hazard ratios (HR) and 95% confidence intervals (CI) for exposure quartiles (Q), tertiles (T), or medians, depending on the number of cancer cases. In adjusted models, nitrite intake from processed meats was associated with an increased risk of stomach cancer (HRQ4vsQ1 = 2.2, CI: 1.2–4.3). A high intake of total dietary nitrite was inversely associated with gallbladder cancer (HRQ4vsQ1 = 0.3, CI: 0.1–0.96), driven by an inverse association with plant sources of nitrite (HRQ4vsQ1 = 0.3, CI: 0.1–0.9). Additionally, small intestine cancer was inversely associated with a high intake of animal nitrite (HRT3vsT1 = 0.2, CI: 0.1–0.7). There were no other dietary associations. Nitrate concentrations in PWS (average, years ≥ 1/2 the maximum contaminant level) were not associated with cancer incidence. Our findings for stomach cancer are consistent with prior dietary studies, and we are the first to evaluate nitrate and nitrite ingestion for certain gastrointestinal cancers.
Understanding Risk Perception toward Food Safety in Street Food: The Relationships among Service Quality, Values, and Repurchase Intention
Authors: Seo Kyung Hwa , Lee Jee Hye
Published: June 2021

This paper aims to identify service quality dimensions of street food that have an impact on utilitarian and hedonic values and to determine the effect of utilitarian and hedonic values on repurchase intention. It also examines the moderating effect of risk perception toward street food safety on the relationship between service quality and perceived value. An Internet survey was performed in Korea with 285 respondents. The results confirmed that the five dimensions of street food’s service quality—food quality, employee service, physical environment, price, and rapidity of service—had positive impacts on utilitarian and hedonic values. All perceived value (utilitarian, hedonic) has an impact on repurchase intention. Finally, the food quality of street food showed a stronger influence on utilitarian value among the low-risk perception group than the high-risk perception group depending on the consumers’ level of awareness of food safety. This provides new insights for marketing strategies to attract domestic/foreign consumers to street food vendors and for creating a new food culture by emphasizing important domains of service quality, the relation of quality to consumer values, and risk perception toward food safety in street food.
Environmental Footprint of Wastewater Treatment: A Step Forward in the Use of Toxicological Tools
Authors: Bertanza Giorgio , Boniotti Jennifer , Ceretti Elisabetta , Feretti Donatella , Mazzoleni Giovanna , Menghini Michele , Pedrazzani Roberta , Steimberg Nathalie , Urani Chiara , Viola Gaia Claudia Viviana , Zerbini Ilaria , Ziliani Emanuele
Published: June 2021

The assessment of the actual impact of discharged wastewater on the whole ecosystem and, in turn, on human health requires the execution of bioassays. In effect, based on the chemical characterization alone, the synergistic/antagonistic effect of mixtures of pollutants is hardly estimable. The aim of this work was to evaluate the applicability of a battery of bioassays and to suggest a smart procedure for results representation. Two real wastewater treatment plants were submitted to analytical campaigns. Several baseline toxicity assays were conducted, together with tests for the determination of endocrine activity, genetic toxicity and carcinogenicity of wastewater. A “traffic light” model was adopted for an easy-to-understand visualization of the results. Although the legal prescriptions of chemical parameters are fully complied with, bioassays show that a certain biological activity still residues in the treated effluents. Moreover, influent and effluent responses are not always appreciably different. Some tests employing human cells were revealed to be only partially adequate for environmental applications. An interesting and helpful development of the present approach would consist in the estimation of biological equivalents of toxicity, as shown for the estrogenic compound 17-β-estradiol.
An Umbrella Review of the Work and Health Impacts of Working in an Epidemic/Pandemic Environment
Authors: Fan Jonathan , Senthanar Sonja , Macpherson Robert A. , Sharpe Kimberly , Peters Cheryl E. , Koehoorn Mieke , McLeod Christopher B.
Published: June 2021

This umbrella review of reviews examined the evidence on the work and health impacts of working in an epidemic/pandemic environment, factors associated with these impacts, and risk mitigation or intervention strategies that address these factors. We examined review articles published in MEDLINE, PsycINFO and Embase between 2000 and 2020. Data extracted from the included reviews were analyzed using a narrative synthesis. The search yielded 1524 unique citations, of which 31 were included. Included studies were focused on health care workers and the risk of infection to COVID-19 or other respiratory illnesses, mental health outcomes, and health care workers’ willingness to respond during a public health event. Reviews identified a variety of individual, social, and organizational factors associated with these work and health outcomes as well as risk mitigation strategies that addressed study outcomes. Only a few reviews examined intervention strategies in the workplace such as physical distancing and quarantine, and none included long-term outcomes of exposure or work during an epidemic/pandemic. Findings suggest a number of critical research and evidence gaps, including the need for reviews on occupational groups potentially exposed to or impacted by the negative work and health effects of COVID-19 in addition to health care workers, the long-term consequences of transitioning to the post-COVID-19 economy on work and health, and research with an equity or social determinants of health lens.
A Cross-Sectional Study: What Contributes to Nursing Students’ Clinical Reasoning Competence?
Authors: Hong Soomin , Lee JuHee , Jang Yeonsoo , Lee Yoonju
Published: June 2021

Clinical reasoning is a vital competence for nursing students, as it is required for solving problems arising in complex clinical situations. Identifying the factors that influence nursing students’ clinical reasoning competence in the social context can help their implicit educational needs. Therefore, this study aimed to determine the factors associated with developing clinical reasoning competency among undergraduate nursing students. In total, 206 senior nursing students were included in this study. Self-reported measures were used to obtain data on participants’ clinical reasoning competence, problem-solving abilities, academic self-efficacy, and level of clinical practicum stress. Relationships among continuous variables were analyzed using Pearson’s correlation coefficients. A multiple linear regression analysis was conducted to identify factors related to clinical reasoning competence. Our findings show that participants with better problem-solving abilities and academic self-efficacy perceived themselves as having higher levels of clinical reasoning competence. Nursing students with lower clinical practicum stress reported higher clinical reasoning competence. Significant factors identified were younger age and subcategories of problem-solving ability such as problem clarification, alternative solution development, planning/implementation, and self-regulated efficacy. Our findings highlight essential factors necessary for developing a nursing curriculum that contributes to professional nurses’ clinical reasoning competence.
Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies
Authors: Caserta Donatella , Costanzi Flavia , De Marco Maria Paola , Di Benedetto Luisa , Matteucci Eleonora , Assorgi Chiara , Pacilli Maria Clara , Besharat Aris Raad , Bellati Filippo , Ruscito Ilary
Published: June 2021

Several available studies have already analyzed the systemic effects of endocrine-disrupting chemicals (EDCs) on fertile woman and neonatal outcomes, but little is still known in humans about the precise mechanisms of interference of these compounds with the endometrial receptivity. There is consistent evidence that continuous and prolonged exposure to EDCs is a risk factor for reduced fertility and fecundity in women. Preliminary studies on mammalian models provide robust evidence about this issue and could help gynecologists worldwide to prevent long term injury caused by EDCs on human fertility. In this systematic review, we aimed to systematically summarize all available data about EDC effects on blastocyst endometrial implantation. We performed a systematic review using PubMed®/MEDLINE® to summarize all in vivo studies, carried out on mice models, analyzing the molecular consequences of the prolonged exposure of EDC on the implantation process. 34 studies carried out on mouse models were included. Primary effects of EDC were a reduction of the number of implantation sites and pregnancy rates, particularly after BPA and phthalate exposure. Furthermore, the endometrial expression of estrogen (ER) and progesterone receptors (PR), as well as their activation pathways, is compromised after EDC exposure. Finally, the expression of the primary endometrial markers of receptivity (such as MUC1, HOXA10, Inn and E-cadherin) after EDC contact was analyzed. In conclusion EDC deeply affect blastocyst implantation in mouse model. Several players of the implantation mechanism are strongly influenced by the exposure to different categories of EDC.
Barriers and Facilitators of Nurses’ and Physicians’ Willingness to Work during a Respiratory Disease Outbreak: A Mixed-Methods Systematic Review
Authors: Lee Hyun Jie , Kim Eunkyung , Morse Brenna L. , Lee Seung Eun
Published: June 2021

This review was undertaken to identify the perceived barriers and facilitators of nurses’ and physicians’ willingness to work during a respiratory disease outbreak. This mixed-methods systematic review involved the extraction of data from the electronic databases PubMed, Web of Science, CINAHL, and PsycINFO and from a manual search of articles published between 2003 and April 2021. The quality of the included studies was assessed using a mixed-method appraisal tool. A total of 29 studies were eligible for inclusion: 21 quantitative and 8 qualitative. Using the Integrated Behavioral Model, perceived barriers and facilitators were identified under seven categories: demographics, attitude, perceived norm, personal agency, knowledge and skills to perform the behavior, environmental constraints, and habit. The results of this study broaden the understanding of various factors that affect nurses’ and physicians’ willingness to work during a respiratory disease outbreak. These findings will facilitate the modification of current pandemic workplace staffing strategies and practices and will inform preparedness planning for similar situations in the future.
Availability, Nutritional Profile and Processing Level of Food Products Sold in Vending Machines in a Spanish Public University
Authors: Martinez-Perez Naiara , Arroyo-Izaga Marta
Published: June 2021

Background. Given the lack of data about the nutritional value and other determinants of the consumption of foods and drinks sold in vending machines in European universities and the relevance of this sector in Spain, it is necessary to obtain scientific data on this topic. The present study aimed to assess the availability, nutritional profile and processing level of food products from vending machines at a Spanish public university and to investigate differences in nutritional profile according to the cost and promotion. Methods. Cross-sectional descriptive study. Data from all products available (3894) were collected and analysed using the criteria of the Spanish Agency for Consumption, Food Safety and Nutrition and the United Kingdom nutrient profiling model. The items were also classified according to the degree of industrial processing through the NOVA system. Promotion was assessed, taking into account where products were displayed in vending machines. Results. The most common products were sweets (23.4% of the total options), coffee (20.3%) and salty snacks (11.7%). According to the combination of the two criteria used to assess nutritional profile, 48.6% of the products were classified as with low nutritional quality (LNQ). In addition, 73.8% of the items were categorised as “ultra-processed”. Foods (β = 0.31, 95% CI 0.24, 0.39, p < 0.001) and hot drinks (β = 0.46, 95% CI 0.39, 0.52, p < 0.001) with high nutritional quality (HNQ) were more likely to have higher prices than alternatives with LNQ. Both foods and cold drinks that support healthy dietary recommendations were promoted to a lesser extent than those with LNQ (p < 0.001). Conclusion. Almost half of the products were of LNQ and three-quarters had a high level of processing. Moreover, foods and cold drinks with LNQ were less expensive and more often promoted than alternatives with HNQ.
Commercial Gilthead Seabream (Sparus aurata L.) from the Mar Menor Coastal Lagoon as Hotspots of Microplastic Accumulation in the Digestive System
Authors: Bayo Javier , Rojo Dolores , Martínez-Baños Pedro , López-Castellanos Joaquín , Olmos Sonia
Published: June 2021

This paper presents the results on the presence and characterization of microplastics (MP) in the gastrointestinal tract of gilthead seabream (Sparus aurata L.), a species of commercial interest from the Mar Menor coastal lagoon in Southeast Spain. This is the first time that microplastic ingestion is recorded in any species from this semi-enclosed bay. Stomach and intestine from a total of 17 specimens captured by local fishermen were processed, and microplastic particles and fibers found in all of them were displayed. Overall, 40.32% (279/692) of total isolated microparticles proved to be microplastics; i.e., <5 mm, as identified by FTIR spectroscopy. The average value by fish was 20.11 ± 2.94 MP kg−1, corresponding to average concentrations of 3912.06 ± 791.24 and 1562.17 ± 402.04 MP by kg stomach and intestine, respectively. Four MP forms were isolated: fiber (71.68%), fragment (21.15%), film (6.81%), and microbead (0.36%), with sizes ranging from 91 µm to 5 mm, an average of 0.83 ± 0.04 mm, and no statistically significant differences between mean sizes in stomach and intestine samples (F-test = 0.004; p = 0.936). Nine polymer types were detected, although most of fibers remained unidentified because of their small size, the presence of polymer additives, or closely adhered pollutants despite the oxidizing digestion carried out to eliminate organic matter. No significant correlation was found between main biological parameters and ingested microplastics, and high-density polyethylene (HDPE), low-density polyethylene (LDPE), polyethylene polypropylene (PEP), and polyvinyl (PV) were identified as the most abundant polymers. The average microplastic ingestion in this study area was higher than those reported in most studies within the Mediterranean Sea, and closely related to microplastic pollution in the surrounding area, although with a predominance of fiber form mainly due to fishery activities.
Near-Source Risk Functions for Particulate Matter Are Critical When Assessing the Health Benefits of Local Abatement Strategies
Authors: Segersson David , Johansson Christer , Forsberg Bertil
Published: June 2021

When mortality or other health outcomes attributable to fine particulate matter (PM2.5) are estimated, the same exposure–response function (ERF) is usually assumed regardless of the source and composition of the particles, and independently of the spatial resolution applied in the exposure model. While several recent publications indicate that ERFs based on exposure models resolving within-city gradients are steeper per concentration unit (μgm−3), the ERF for PM2.5 recommended by the World Health Organization does not reflect this observation and is heavily influenced by studies based on between-city exposure estimates. We evaluated the potential health benefits of three air pollution abatement strategies: electrification of light vehicles, reduced use of studded tires, and introduction of congestion charges in Stockholm and Gothenburg, using different ERFs. We demonstrated that using a single ERF for PM2.5 likely results in an underestimation of the effect of local measures and may be misleading when evaluating abatement strategies. We also suggest applying ERFs that distinguish between near-source and regional contributions of exposure to PM2.5. If separate ERFs are applied for near-source and regional PM2.5, congestion charges as well as a reduction of studded tire use are estimated to be associated with a significant reduction in the mortality burden in both Gothenburg and Stockholm. In some scenarios the number of premature deaths is more than 10 times higher using separate ERFs in comparison to using a single ERF irrespective of sources as recommended by the WHO. For electrification, the net change in attributable deaths is small or within the uncertainty range depending on the choice of ERF.
Child Maltreatment and Public Health: Do Gaps in Response during the COVID-19 Pandemic Highlight Jurisdictional Complexities?
Authors: Davison Colleen M. , Thanabalasingam Susan J. , Purkey Eva M. , Bayoumi Imaan
Published: June 2021

Objective: Countermeasures introduced during the COVID-19 pandemic produced an environment that placed some children at increased risk of maltreatment at the same time as there were decreased opportunities for identifying and reporting abuse. Unfortunately, coordinated government responses to address child protection since the start of the pandemic have been limited in Canada. As an exploratory study to examine the potential academic evidence base and location of expertise that could have been used to inform COVID-19 pandemic response, we undertook a review of child maltreatment research across three prominent Canadian professional journals in social work, medicine and public health. Methods: We conducted a pre-pandemic, thirteen-year (2006–2019) archival analysis of all articles published in the Canadian Social Work Review (CSWR), the Canadian Medical Association Journal (CMAJ) and the Canadian Journal of Public Health (CJPH) and identified the research articles that related directly to child maltreatment, child protection or the child welfare system in Canada. Results: Of 11,824 articles published across the three journals, 20 research papers relating to child maltreatment, child protection or the child welfare system were identified (CJPH = 7; CMAJ = 3; CSWR = 10). There was no obvious pattern in article topics by discipline. Discussion: Taking these three prominent professional journals as a portal into research in these disciplines, we highlight the potential low volume of academic child maltreatment research despite the importance of the topic and irrespective of discipline. We believe that urgent transdisciplinary collaboration and overall awareness raising for child protection is called for at the time of the COVID-19 pandemic as well as beyond in Canada.
Multifaceted Role of the Transforming Growth Factor β on Effector T Cells and the Implication for CAR-T Cell Therapy
Authors: de Folmont Apolline , Bourhis Jean-Henri , Chouaib Salem , Terry Stéphane
Published: June 2021

Evading the immune system is one of the hallmarks of cancer. Tumors escape anti-tumor immunity through cell-intrinsic means and the assembly of an immunosuppressive tumor microenvironment. By significantly boosting the host immune system, cancer immunotherapies targeting immune checkpoint receptors (CTLA-4 and PD-1) improved survival in patients even with cancers previously considered rapidly fatal. Nevertheless, an important group of patients is refractory or relapse rapidly. The factors involved in the heterogeneous responses observed are still poorly understood. Other immunotherapeutic approaches are being developed that may widen the options, including adoptive cell therapy using CAR-T cells alone or in combination. Despite impressive results in B cell malignancies, many caveats and unanswered questions remain in other cancers, thus limiting the potential of this approach to treat aggressive diseases. In particular, a complex TME could impair the survival, proliferation, and effector functions of CAR-T cells. Recent reports highlight the potential of targeting TGF-β signaling to improve CAR-T cell therapy. TGF-β is a well-known regulatory cytokine with pleiotropic effects in the TME, including immunosuppression. This review summarizes recent work investigating the potential effects of TGF-β within the TME, with a focus on CAR-T behavior and efficacy. We also discuss several key questions to be addressed to accelerate clinical translation of this approach.
Changes in Lithium Levels in Bees and Their Products Following Anti-Varroa Treatment
Authors: Kolics Éva , Sajtos Zsófi , Mátyás Kinga , Szepesi Kinga , Solti Izabella , Németh Gyöngyi , Taller János , Baranyai Edina , Specziár András , Kolics Balázs
Published: June 2021

The biggest threat to beekeeping is varroosis caused by the mite Varroa destructor. Chemicals available to treat this fatal disease may present problems of resistance or inconsistent efficacy. Recently, lithium chloride has appeared as a potential alternative. To date, the amount of residue lithium treatments may leave in honeybee products is poorly understood. Honeybees were fed with 25 mM lithiated sugar syrup, which was used in earlier studies. The accumulation and elimination of the lithium were monitored in bees and their products for 22 days. Lithium concentration increased in the entire body of the bees to day 4 post-treatment and then recovered rapidly to the control level. Lithium exposure was found to affect uncapped honey in the short term (<16 days), but ripe (capped) honey measured at the end of the trial remained affected. On the other hand, lithium treatment left beeswax lithium-free. Based on these data, we propose that comprehensive research on harvested honey is needed to decide on the veterinary use of lithium.
SARS-CoV-2 and Cytomegalovirus Co-Infections—A Case Series of Critically Ill Patients
Authors: Moniz Patrícia , Brito Sérgio , Póvoa Pedro
Published: June 2021

The SARS-CoV-2 pandemic has placed great strain on the most developed of health care systems, especially in the context of critical care. Although co-infections with cytomegalovirus (CMV) are frequent in the critically ill due to underlying immune suppression of multiple causes, the impact on COVID-19 patients remains unclear. Furthermore, severe COVID-19 has recently been associated with significant immune suppression, and this may in turn impact CMV reactivation, possibly contributing to clinical course. Nevertheless, multiple confounding factors in these patients will certainly challenge upcoming research. The authors present a case series of five patients admitted to the intensive care unit (ICU) in the context of respiratory failure due to severe COVID-19. All patients evolved with CMV reactivation during ICU stay.