bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Pulsed Electric Field Pre-Treatment and the Freezing Methods on the Kinetics of the Freeze-Drying Process of Apple and Its Selected Physical Properties
Authors: Nowak Dorota , Jakubczyk Ewa
Published: August 2022

The aim of this study was to investigate the effect of application of pulsed electric field (PEF) and different freezing methods (fast, slow and vacuum freezing) on the drying kinetics as well as selected physical properties of freeze-dried apple. The apples were subjected to PEF treatment with range of pulses from 0 to 160 and the intake energy from 0 to 1327 kJ·g−1. Apples with and without PEF treatment were frozen with different rates and the freeze-dried. The water content, water activity and colour attributes of freeze-dried apples were investigated. Regression analysis and fitting procedures showed that among six different models, the Midilli et al. model the best described the drying curves of all dried samples. The highest value of the parameter L* = 71.54 was obtained for freeze-dried sample prepared without PEF pre-treatment and fast frozen. Application of PEF pre-treatment resulted in increase in browning index of freeze-dried apples (BI). The studies confirmed the positive effect of PEF on the freeze drying rate only in the case of the slow or fast freezing of the material after the application of low-energy PEF treatment. However, the increase in drying rate was also observed after application of slow and vacuum freezing of the material without PEF pre-treatment. These technologies can be recommended for optimization of the freeze drying process of apples. The statement that the freeze drying process with application of appropriately selected PEF processing parameters causing only partial destruction of cell membranes can be considered as an innovative contribution to the development of science about the possibilities of PEF application.
Valorization of Tomato Seed By-Products as a Source of Fatty Acids and Bioactive Compounds by Using Advanced Extraction Techniques
Authors: Solaberrieta Ignacio , Mellinas Ana Cristina , Espagnol Jérémy , Hamzaoui Mahmoud , Jiménez Alfonso , Garrigós María Carmen
Published: August 2022

In this work, lipids and bioactive compounds from tomato seed by-products were extracted and compared by using advanced extraction techniques, such as microwave-assisted extraction (MAE) and supercritical fluid extraction (SFE). The influence of different extraction parameters, including extraction temperature (T), time (t) and solvent volume (V) for MAE as well as extraction temperature (T), pressure (P) and flow rate (F) for SFE-CO2, was evaluated on tomato seed oil (TSO) yield and fatty acids composition using response surface methodology (RSM). Optimum extraction conditions for MAE were 56.2 °C, 29.0 min, and 67.6 mL, whereas conditions of 60.2 °C, 400.0 bar, and 64.6 g min−1 were found for SFE-CO2. Under these conditions, higher TSO extraction yields were obtained by MAE compared to SFE-CO2 (25.3 wt% and 16.9 wt%, respectively), while similar fatty acids profiles were found by GC in terms of FAMEs composition: methyl palmitate, methyl stearate, methyl oleate, and methyl linoleate, accounting for around 80 wt% of unsaturated fatty acids. TSO MAE extracts showed high DPPH• radical scavenging activity which was related to the presence of tocopherols; in particular γ-tocopherol, which was found as the dominant homologue (260.3 ± 0.6 mg kgTS−1) followed by a lower amount of α-tocopherol (6.53 ± 0.12 mg kgTS−1) by HPLC-DAD. The obtained results suggested that tomato seeds are an interesting source of bioactive compounds with potential use in a wide range of nutritional and food applications, increasing the added value of this by-product, which is currently underexploited.
Structural Insights and Development of LRRK2 Inhibitors for Parkinson’s Disease in the Last Decade
Authors: Thakur Gunjan , Kumar Vikas , Lee Keun Woo , Won Chungkil
Published: August 2022

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, characterized by the specific loss of dopaminergic neurons in the midbrain. The pathophysiology of PD is likely caused by a variety of environmental and hereditary factors. Many single-gene mutations have been linked to this disease, but a significant number of studies indicate that mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a potential therapeutic target for both sporadic and familial forms of PD. Consequently, the identification of potential LRRK2 inhibitors has been the focus of drug discovery. Various investigations have been conducted in academic and industrial organizations to investigate the mechanism of LRRK2 in PD and further develop its inhibitors. This review summarizes the role of LRRK2 in PD and its structural details, especially the kinase domain. Furthermore, we reviewed in vitro and in vivo findings of selected inhibitors reported to date against wild-type and mutant versions of the LRRK2 kinase domain as well as the current trends researchers are employing in the development of LRRK2 inhibitors.
Reliability of My Jump 2 Derived from Crouching and Standing Observation Heights
Authors: Jimenez-Olmedo Jose M. , Pueo Basilio , Mossi Jose M. , Villalon-Gasch Lamberto
Published: August 2022

The crouching or prone-on-the-ground observation heights suggested by the My Jump app are not practical in some settings, so users usually hold smartphones in a standing posture. This study aimed to analyze the reliability of My Jump 2 from the standardized and standing positions. Two identical smartphones recorded 195 countermovement jump executions from 39 active adult athletes at heights 30 and 90 cm, which were randomly assessed by three experienced observers. The between-observer reliability was high for both observation heights separately (ICC~0.99; SEM~0.6 cm; CV~1.3%) with low systematic (0.1 cm) and random (±1.7 cm) errors. The within-observer reliability for the three observers comparing the standardized and standing positions was high (ICC~0.99; SEM~0.7 cm; CV~1.4%), showing errors of 0.3 ± 1.9 cm. Observer 2 was the least accurate out of the three, although reliability remained similar to the levels of agreement found in the literature. The reliability of the mean observations in each height also revealed high reliability (ICC = 0.993; SEM = 0.51 cm; CV = 1.05%, error 0.32 ± 1.4 cm). Therefore, the reliability in the standing position did not change with respect to the standardized position, so it can be regarded as an alternative method to using My Jump 2 with practical added benefits.
The Effect of Exercise Intensity on Affective and Repetition Priming in Middle-Aged Adults
Authors: Perez-Rojo Cristina , Rieker Jennifer A. , Ballesteros Soledad
Published: August 2022

Previous research has shown that physical exercise improves memory. In the present study, we investigated the possible effects of the intensity of physical exercise as a function of the affective valence of words on implicit memory. In the study, 79 young adult volunteers were randomly assigned to perform moderate- (50% VO2max) or high-intensity exercise (80% VO2max) on a stationary bike. Once the required exercise intensity was achieved, participants performed an affective and repetition priming task concurrently with the physical exercise. Both groups showed similar repetition priming. The moderate-intensity exercise group showed affective priming with positive words, while affective priming was not found in the high-intensity exercise group. Facilitation occurred in both groups when a negative target word was preceded by a positive prime word. Our results suggest that the positive effect of physical exercise on memory is modulated by the affective valence of the stimuli. It seems that moderate-intensity exercise is more beneficial for implicit memory than high-intensity exercise.
Particulate Matter Exposure after a Cancer Diagnosis and All-Cause Mortality in a Regional Cancer Registry-Based Cohort in South Korea
Authors: Eom Sang-Yong , Kim Yong-Dae , Kim Heon
Published: August 2022

Although particulate matter (PM) is a Group 1 carcinogen, few studies have evaluated the effect of PM exposure after a cancer diagnosis on survival. Herein, we evaluated the effect of exposure to ambient PM10 after a cancer diagnosis on survival using data from the Regional Cancer Registry cohort in Chungbuk Province, Korea. A total of 44,432 patients with cancer who survived for >1 year after being diagnosed between 2005 and 2018 were followed until 31 December 2019; there were 32,734 survivors (73.7%) and 11,698 deceased (26.3%). The average follow-up period was 67.7 months, and the cumulative average concentration of PM10 exposure of patients with cancer after a diagnosis was 49.0 µg/m3. When PM10 concentration increased by 1 standard deviation (5.2 µg/m3), the all-cause mortality risk increased 2.06-fold (95% CI: 2.02–2.11). This trend was most pronounced in the younger patient group and in patients with local-stage cancer. This study demonstrates that exposure to PM10 after cancer diagnosis might influence the survival of patients with cancer, requiring environmental preventive measures such as lower pollutant exposure.
Traditional Heart-Healthy Diet and Medication Adherence in the Norton Sound Region: An 18-Month Telehealth Intervention
Authors: Oppezzo Marily , Knox Mariah , Skan Jordan , Chieng Amy , Crouch Maria , Aikens Rachael C. , Benowitz Neal L. , Schnellbaecher Matthew , Prochaska Judith J.
Published: August 2022

Introduction. Innovations are needed for preventing cardiovascular disease (CVD) and for reaching diverse communities in remote regions. The current study reports on a telemedicine-delivered intervention promoting a traditional heart-healthy diet and medication adherence with Alaska Native men and women residing in the Norton Sound region of Alaska. Methods. Participants were 299 men and women with high blood pressure or high cholesterol smoking daily who were randomized to receive telemedicine-delivered counseling and printed materials on diet and medication adherence or on smoking and physical activity. Intervention contacts were at baseline and 3-, 6-, and 12-months follow-up, with a final assessment at 18 months. Nutrition outcomes were the ratio of heart-healthy foods and traditional heart-healthy foods relative to all foods reported on a 34-item food frequency questionnaire. Recent and typical adherence for heart medications were self-reported. Results. Intervention effects were significant for the heart-healthy foods ratio at 6 months only (p = 0.014) and significant for the traditional heart-healthy foods ratio at 6 months only for those aged 47+ (p = 0.031). For recent and typical medication adherence, there were no significant group differences by time. Discussion. In a remote region of Alaska, telemedicine proved feasible and acceptable for engaging Alaska Native men and women in counseling on CVD risk behaviors. The findings indicate that more touchpoints may be necessary to impart comprehensive lasting change in heart-healthy eating patterns. Medication adherence group differences were not significant; however, medication adherence was high overall.
Characterisation of Particles Emitted during Laser Cutting of Various Metal Sheets and an Exposure Assessment for the Laser Operators
Authors: Eriksen Hammer Stine , Halvorsen Johanne Østereng , Graff Pål , Ervik Torunn Kringlen
Published: August 2022

Laser cutting is used in many industrial settings to achieve precise cuts of metal sheets. Laser operators may be exposed to particles formed during cutting when opening the cabinet or when metal sheets are exchanged. To characterise the potential exposure, particles formed during laser cutting were studied with scanning electron microscopy equipped with an energy dispersive X-ray detector and an energy backscatter diffraction detector. The total concentration of particles (11–615 nm) was determined online with a scanning mobility particle sizer. The chemical composition of the particles formed during the cutting of the different metal sheets was determined by inductively coupled plasma mass spectrometry (ICP-MS). X-ray diffraction was applied to determine the phase composition. The occupational exposure was assessed gravimetrically and by ICP-MS for five laser operators handling different laser cutters, and materials and were found to be low. Agglomerates and aggregates of condensation particles were formed during laser cutting, independent of the sheet type. Iron, present as both magnetite and α-Fe, was the main element found in the particles formed when cutting steel sheets. The size of the particles generated was mainly below 300 nm. Open laser cutters may lead to higher metal exposures, which is especially relevant when cutting metal sheets containing heavy metals.
Religiosity and COVID-19: Impact on Use of Remote Worship and Changes in Self-Reported Social Support
Authors: Mosavel Maghboeba , Hoadley Ariel , Akinkugbe Aderonke A. , Garcia Dina T. , Bass Sarah Bauerle
Published: August 2022

Objective: This study examines associations between changes in the use of remote worship services and changes in the types of social support among religious adults during the COVID-19 pandemic. Materials and Methods: Cross-sectional, web survey data (n = 461; 15 May to 6 July 2020) were collected during the COVID-19 pandemic. Multinomial logistic regression models calculated unadjusted odds of increases and decreases of three types of perceived social support from before to during COVID-19 based on remote worship use. Results: Adults who initiated use of remote worship had lower odds of gaining social support for personal problems (OR: 0.38; 95% CI: 0.19, 0.79) and greater odds of reporting less ease of getting practical help from neighbors (OR: 1.77; 95% CI: 1.04, 3.02) compared to adults who never used or stopped using remote worship. Adults who continued using remote worship services were more likely to report less ease of getting practical help from their neighbors (OR: 2.23; 95% CI: 1.17, 4.25) and decreased interest and concern felt from other people (OR: 2.62; 95% CI: 1.24, 5.51) than adults who never used or stopped using remote worship. Conclusions: Adults who initiated and continued using remote worship during the COVID-19 pandemic had poorer perceived social support outcomes relative to adults who never used or stopped using remote services. Despite continued engagement with their religious communities, adults participating in worship remotely may have had residual personal, emotional, and instrumental social support needs that remote worship did not mitigate.
Family Factors Related to Suicidal Behavior in Adolescents
Authors: Alvarez-Subiela Xavier , Castellano-Tejedor Carmina , Villar-Cabeza Francisco , Vila-Grifoll Mar , Palao-Vidal Diego
Published: August 2022

Objective: This research aims to investigate what type of family patterns (specifically attachment, bonding and family functioning) and stressful life events can trigger or protect adolescents from developing suicidal behavior. Methods: For these purposes, a case-control study (adolescents with suicidal behavior vs. paired adolescents with no suicidal behavior) was conducted with one hundred 12 to 17-year-old adolescents (50 controls, 50 cases, 74% females), assessed between 2018 and 2020. Results: Negligent (p < 0.001) or affection-less control bonding (p < 0.001), insecure attachment (p = 0.001) and stressful life events (p < 0.001) revealed to be significant risk factors for suicidal behavior. On the contrary, parents’ care (p < 0.001) and security (p < 0.001) were revealed as protective factors for suicidal behavior. Conclusions: Considering these results, family interventions and improving coping skills seem to be two essential targets for any suicide prevention intervention in adolescents.
Study on the Applicability and Modification of the Design Hourly Volume on Rural Expressways Considering Holiday Traffic Polarization
Authors: Ma Fangchen , Xu Jinliang , Gao Chao , Bi Yufeng
Published: August 2022

The design hourly volume (DHV) of traffic based on the 30th highest hourly volume (30 HV) of the year has been widely applied in expressway design in various countries to balance the benefit and economy of expressway engineering. However, this design method has barely changed since it was first adopted in China, which may be contrary to the rapidly changing traffic macroenvironment. In this study, annual hourly traffic volume (HV) data pertaining to expressways in East China, Southwest China and Northwest China were collected. Based on the descending order of the obtained HV and HV factor data, the distribution patterns of the traffic demand throughout the year and peak hours were analyzed. The distribution characteristics of the HV, typicality of 30 HV and applicability of the DHV factor were investigated. It was found that severe polarization occurred in the HV distribution in China. The actual 30 HV factor is more than 0.5 times the recommended value in the specification. Continued use of the current DHV would result in more than 200 h of inefficient travel time, 5.7 times more than expected, with the DHV factor is currently no longer applicable in China. Furthermore, the annual 30 HV value loses its typical status. Depending on the level of local economic development, using 10 HV factor or 80 HV factor as the new DHV factor can better alleviate the congestion problem. This study determines the reasons for the widespread congestion issues in China from the perspective of expressway design, which is beneficial to adjust the basis of expressway design in China.
VHRShips: An Extensive Benchmark Dataset for Scalable Deep Learning-Based Ship Detection Applications
Authors: Kızılkaya Serdar , Alganci Ugur , Sertel Elif
Published: August 2022

The classification of maritime boats and ship targets using optical satellite imagery is a challenging subject. This research introduces a unique and rich ship dataset named Very High-Resolution Ships (VHRShips) from Google Earth images, which includes diverse ship types, different ship sizes, several inshore locations, and different data acquisition conditions to improve the scalability of ship detection and mapping applications. In addition, we proposed a deep learning-based multi-stage approach for ship type classification from very high resolution satellite images to evaluate the performance of the VHRShips dataset. Our “Hierarchical Design (HieD)” approach is an end-to-end structure that allows the optimization of the Detection, Localization, Recognition, and Identification (DLRI) stages, independently. We focused on sixteen parent ship classes for the DLR stages, and specifically considered eight child classes of the navy parent class at the identification stage. We used the Xception network in the DRI stages and implemented YOLOv4 for the localization stage. Individual optimization of each stage resulted in F1 scores of 99.17%, 94.20%, 84.08%, and 82.13% for detection, recognition, localization, and identification, respectively. The end-to-end implementation of our proposed approach resulted in F1 scores of 99.17%, 93.43%, 74.00%, and 57.05% for the same order. In comparison, end-to-end YOLOv4 yielded F1-scores of 99.17%, 86.59%, 68.87%, and 56.28% for DLRI, respectively. We achieved higher performance with HieD than YOLOv4 for localization, recognition, and identification stages, indicating the usability of the VHRShips dataset in different detection and classification models. In addition, the proposed method and dataset can be used as a benchmark for further studies to apply deep learning on large-scale geodata to boost GeoAI applications in the maritime domain.
Protease Profile of Tumor-Associated Mast Cells in Melanoma
Authors: Atiakshin Dmitri , Kostin Andrey , Buchwalow Igor , Samoilova Vera , Tiemann Markus
Published: August 2022

Mast cells (MCs) produce a variety of mediators, including proteases—tryptase, chymase, and carboxypeptidases—which are important for the immune response. However, a detailed assessment of the mechanisms of biogenesis and excretion of proteases in melanoma has yet to be carried out. In this study, we present data on phenotype and secretory pathways of proteases in MCs in the course of melanoma. The development of melanoma was found to be accompanied by the appearance in the tumor-associated MC population of several pools with a predominant content of one or two specific proteases with a low content or complete absence of others. Elucidation of the molecular and morphological features of the expression of MC proteases in melanoma allows us a fresh perspective of the pathogenesis of the disease, and can be used to clarify MCs classification, the disease prognosis, and evaluate the effectiveness of ongoing antitumor therapy.
Elastic Fibers in the Intervertebral Disc: From Form to Function and toward Regeneration
Authors: Cyril Divya , Giugni Amelia , Bangar Saie Sunil , Mirzaeipoueinak Melika , Shrivastav Dipika , Sharabi Mirit , Tipper Joanne L. , Tavakoli Javad
Published: August 2022

Despite extensive efforts over the past 40 years, there is still a significant gap in knowledge of the characteristics of elastic fibers in the intervertebral disc (IVD). More studies are required to clarify the potential contribution of elastic fibers to the IVD (healthy and diseased) function and recommend critical areas for future investigations. On the other hand, current IVD in-vitro models are not true reflections of the complex biological IVD tissue and the role of elastic fibers has often been ignored in developing relevant tissue-engineered scaffolds and realistic computational models. This has affected the progress of IVD studies (tissue engineering solutions, biomechanics, fundamental biology) and translation into clinical practice. Motivated by the current gap, the current review paper presents a comprehensive study (from the early 1980s to 2022) that explores the current understanding of structural (multi-scale hierarchy), biological (development and aging, elastin content, and cell-fiber interaction), and biomechanical properties of the IVD elastic fibers, and provides new insights into future investigations in this domain.
A Comprehensive Search of Non-Canonical Proteins in Non-Small Cell Lung Cancer and Their Impact on the Immune Response
Authors: Irajizad Ehsan , Fahrmann Johannes F. , Long James P. , Vykoukal Jody , Kobayashi Makoto , Capello Michela , Yu Chuan-Yih , Cai Yining , Hsiao Fu Chung , Patel Nikul , Park Soyoung , Peng Qian , Dennison Jennifer B. , Kato Taketo , Tai Mei Chee , Taguchi Ayumu , Kadara Humam , Wistuba Ignacio I. , Katayama Hiroyuki , Do Kim-Anh , Hanash Samir M. , Ostrin Edwin J.
Published: August 2022

There is substantial interest in mining neoantigens for cancer applications. Non-canonical proteins resulting from frameshift mutations have been identified as neoantigens in cancer. We investigated the landscape of non-canonical proteins in non-small cell lung cancer (NSCLC) and their induced immune response in the form of autoantibodies. A database of cryptoproteins was computationally constructed and comprised all alternate open reading frames (altORFs) and ORFs identified in pseudogenes, noncoding RNAs, and untranslated regions of mRNAs that did not align with known canonical proteins. Proteomic profiles of seventeen lung adenocarcinoma (LUAD) cell lines were searched to evaluate the occurrence of cryptoproteins. To assess the immunogenicity, immunoglobulin (Ig)-bound cryptoproteins in plasmas were profiled by mass spectrometry. The specimen set consisted of plasmas from 30 newly diagnosed NSCLC cases, pre-diagnostic plasmas from 51 NSCLC cases, and 102 control plasmas. An analysis of LUAD cell lines identified 420 cryptoproteins. Plasma Ig-bound analyses revealed 90 cryptoproteins uniquely found in cases and 14 cryptoproteins that had a fold-change >2 compared to controls. In pre-diagnostic samples, 17 Ig-bound cryptoproteins yielded an odds ratio ≥2. Eight Ig-bound cryptoproteins were elevated in both pre-diagnostic and newly diagnosed cases compared to controls. Cryptoproteins represent a class of neoantigens that induce an autoantibody response in NSCLC.
Priming of Cardiopulmonary Bypass with Human Albumin Decreases Endothelial Dysfunction after Pulmonary Ischemia–Reperfusion in an Animal Model
Authors: Selim Jean , Hamzaoui Mouad , Ghemired Antoine , Djerada Zoubir , Chevalier Laurence , Piton Nicolas , Besnier Emmanuel , Clavier Thomas , Dumesnil Anaïs , Renet Sylvanie , Mulder Paul , Doguet Fabien , Tamion Fabienne , Veber Benoît , Bellien Jérémy , Richard Vincent , Baste Jean-Marc
Published: August 2022

The routine use of mechanical circulatory support during lung transplantation (LTx) is still controversial. The use of prophylactic human albumin (HA) or hypertonic sodium lactate (HSL) prime in mechanical circulatory support during LTx could prevent ischemia–reperfusion (IR) injuries and pulmonary endothelial dysfunction and thus prevent the development of pulmonary graft dysfunction. The objective was to investigate the impact of cardiopulmonary bypass (CPB) priming with HA and HSL compared to a CPB prime with Gelofusine (GF) on pulmonary endothelial dysfunction in a lung IR rat model. Rats were assigned to four groups: IR-CPB-GF group, IR-CPB-HA group, IR-CPB-HSL group and a sham group. The study of pulmonary vascular reactivity by wire myograph was the primary outcome. Glycocalyx degradation (syndecan-1 and heparan) was also assessed by ELISA and electron microscopy, systemic and pulmonary inflammation by ELISA (IL-1β, IL-10, and TNF-α) and immunohistochemistry. Clinical parameters were evaluated. We employed a CPB model with three different primings, permitting femoral–femoral assistance with left pulmonary hilum ischemia for IR. Pulmonary endothelium-dependent relaxation to acetylcholine was significantly decreased in the IR-CPB-GF group (11.9 ± 6.2%) compared to the IR-CPB-HA group (52.8 ± 5.2%, p < 0.0001), the IR-CPB-HSL group (57.7 ± 6.3%, p < 0.0001) and the sham group (80.8 ± 6.5%, p < 0.0001). We did not observe any difference between the groups concerning glycocalyx degradation, and systemic or tissular inflammation. The IR-CPB-HSL group needed more vascular filling and developed significantly more pulmonary edema than the IR-CPB-GF group and the IR-CPB-HA group. Using HA as a prime in CPB during Ltx could decrease pulmonary endothelial dysfunction’s IR-mediated effects. No effects of HA were found on inflammation.
Sleep and Psychosocial Characteristics of Children with Narcolepsy According to Their Intellectual Profile: A Case–Control Study
Authors: Thieux Marine , Zhang Min , Marcastel Agathe , Poitrinal Alice , Vassias Fanny , Guyon Aurore , Revol Olivier , Mazza Stephanie , Guignard-Perret Anne , Franco Patricia
Published: August 2022

Adequate intellectual abilities are a protective factor for psychosocial adjustments in chronic disorders. The main objective of this study was to assess the cognitive abilities, sleep, and psychosocial characteristics of children with narcolepsy compared to controls, according to their intellectual profile. Children underwent a polysomnography, completed an intellectual ability assessment, and filled out standardized questionnaires. The group with an intelligence quotient (IQ) in the area of high intellectual potential (high IQ, HIQ) consisted of 25 children with narcolepsy (HIQ-N, 40% boys, median age 11.5 years, 48% with obesity, 60% under treatment) and 25 controls (HIQ-C, 68% boys, median age 11.7 years). Compared to HIQ-C, HIQ-N had a lower perceptual reasoning index and fewer conduct disorders. The group with an IQ in the normal range (NIQ) consisted of 22 children with narcolepsy (NIQ-N, 55% boys, median age 12.1 years, 59% with obesity, 64% under treatment) and 21 controls (NIQ-C, 68% boys, median age 10 years). NIQ-N presented the same intellectual profile as NIQ-C but reported more school difficulties. In children with HIQ, those with narcolepsy appear to have a different cognitive profile than controls. NIQ seems to predict a greater impact of narcolepsy on daily-life functioning.
Sport Related Sudden Death: The Importance of Primary and Secondary Prevention
Authors: Robles Antonio Gianluca , Palamà Zefferino , Nesti Martina , Tunzi Roberto Michele , Delise Pietro , Cavarretta Elena , Penco Maria , Romano Silvio , Sciarra Luigi
Published: August 2022

Sports are a double-edged sword. On the one hand, cardiovascular benefits from sports activity are well-known, and on the other hand, sports may increase the risk of sudden cardiac death (SCD) in subjects with known or unknown cardiovascular diseases. SCD is rare but has a very strong emotional issue. There are many examples involving famous professional athletes, but this is only scratching the surface of a widespread phenomenon that also involves amateur athletes. The importance of safely performing physical activity appears clear in both professional and amateur athletes. In particular, the former undergo a pre-participation screening for SCD primary prevention with different recommendations in each country. On the other hand, a medical examination is not mandatory for non-professional athletes and, therefore, for people who practice sports as an amateur. Widespread distribution of automatic external defibrillators and people trained for cardiopulmonary resuscitation are necessary to promote secondary prevention of SCD. We briefly report a case series of athletes with aborted SCD during sports activity in order to underline and discuss in this review the previously highlighted issues.
Impact of Pelvic Fracture Sites on Fibrinogen Depletion in Patients with Blunt Trauma: A Single-Center Cohort Study
Authors: Kunii Mayuko , Nakao Shunichiro , Nakagawa Yuko , Shimazaki Junya , Ogura Hiroshi
Published: August 2022

Background: We aimed to examine the association of pelvic fracture sites with the minimum fibrinogen level within 24 h after hospital arrival. Methods: We conducted a single-center cohort study using health records review. We included patients with pelvic fractures transported by ambulance to a tertiary-care hospital from January 2012 to December 2018 and excluded those transported from other hospitals or aged younger than 16 years. The pelvic fracture was diagnosed and confirmed by trauma surgeons and/or radiologists. We classified the fracture sites of the pelvis as ilium, pubis, ischium, acetabulum, sacrum, sacroiliac joint diastasis, and pubic symphysis diastasis, and each side was counted separately except for pubic symphysis diastasis. We performed linear regression analysis to evaluate the association between pelvic fracture sites and the minimum fibrinogen level within 24 h of arrival. Results: We analyzed 120 pelvic fracture patients. Their mean age was 47.3 years, and 69 (57.5%) patients were men. The median Injury Severity Score was 24, and in-hospital mortality was 10.8%. The mean minimum fibrinogen level within 24 h of arrival was 171.4 mg/dL. Among pelvic fracture sites, only sacrum fracture was statistically significantly associated with the minimum fibrinogen level within 24 h of arrival (estimate, −34.5; 95% CI, −58.6 to −10.4; p = 0.005). Conclusions: Fracture of the sacrum in patients with pelvic fracture was associated with lower minimum fibrinogen levels within 24 h of hospital arrival and the requirement of blood transfusion.
Concordance between Different Criteria for Metabolic Syndrome in Peruvian Adults Undergoing Bariatric Surgery
Authors: Echevarria-Castro Nataly , Silva-Parra Kevin , Polar-Trinidad Marcos , Sánchez-Vicente Juan C. , Salinas-Sedo Gustavo , Toro-Huamanchumo Carlos J.
Published: August 2022

Background: Metabolic Syndrome (MetS) is a clinical entity that has been linked to several non-communicable diseases. There are various consensuses to determine its presence, such as the IDF, ALAD, Harmonized, AHA/NHLBI, NCEP-ATP III or AACE criteria. However, there is currently no standardization to properly identify it. Objective: To assess the diagnostic concordance between different criteria for MetS in Peruvian adults undergoing bariatric surgery. Methods: We conducted a secondary analysis of the institutional database of a bariatric clinic located in Lima, Peru. We obtained data from adults between 18–59 years who underwent bariatric surgery (Roux-en-Y Gastric Bypass or Sleeve Gastrectomy). According to the Kappa coefficient, a heatplot was designed to analyze the concordance of the criteria. Results: An almost perfect concordance was found between all criteria except AACE. The highest kappa coefficient (κ = 0.980) was recorded between the IDF and ALAD criteria using all the sample. Similar results were obtained when we stratified by sex. Conclusions: This study shows that, excluding the AACE, different criteria for metabolic syndrome could be used in Latino adults undergoing bariatric surgery with similar results. Given the postoperative implications, we believe that IDF and ALAD would be the best options in our population.
Trees in Planters—A Case Study of Time-Related Aspects
Authors: Fleckenstein Christoph , Dervishi Vjosa , Rahman Mohammad A. , Rötzer Thomas , Pauleit Stephan , Ludwig Ferdinand
Published: August 2022

Urban spaces are often dominated by paved surfaces and ongoing processes of densification; consequently, intensifying the urban heat island effect. In order to strengthen the liveability of urban spaces, an adequate amount of green spaces is needed. Trees in planters are an alternative greening solution; however, the lack of root space due to underground infrastructure poses a challenge. Furthermore, temporal aspects such as tree growth, tree death, and growth responses to environmental factors are frequently overlooked in projects that use trees in planters. In multiple case studies that employ the method “Research through Drawing” we analyse five selected projects, which deal in sharply contrasting ways with the temporal aspects of trees in planters. Our results show that promising approaches exist, albeit they are not described explicitly in either written or graphical form. Consequently, temporal aspects are only vaguely considered in the projects’ design concept. This results in the neglect of the further use of trees in planters in temporary projects, or in the disregard for tree death in the design and responses to it in permanent projects. Therefore, the potential of trees in planters as an alternative and complementary greening solution remain unexploited. To overcome this, a coherent temporal approach that considers growth, death of plant parts or whole plants, and that is developed as an integral part of the design concept and communicated graphically, would ensure that the involved actors and their respective tasks are well coordinated throughout the lifetime of a project.
Study on Tribological Characteristics of Textured Surface under Convergent Oil Film Gap
Authors: Bei Guangyao , Ma Chenbo , Wang Xilong , Sun Jianjun , Ni Xingya
Published: August 2022

Under the condition of convergence, a textured non-parallel 2D slider bearing model was established, and the tribological properties of textured surface under the convergence gap were numerically studied with the load-carrying capacity as an indicator. Firstly, whether the convergence ratio parameter can accurately characterize the joint effects of film thickness difference and oil film thickness on the surface tribological properties was verified, and the effects of film thickness difference and oil film thickness on the load-carrying capacity of textured and non-textured surface were studied, respectively. The results show that the efficiency of improving the load-carrying capacity of the surface structure first increases and then decreases with the increase of the oil film thickness. In the case of large film thickness difference, the surface texture will reduce the efficiency of improving the load-carrying capacity. In addition, the effects of texture depth, texture width, and sliding velocity on the load-carrying capacity under the convergence gap are also studied. In particular, an optimal texture width to maximize the load-carrying capacity exists.
A Semi Empirical Regression Model for Critical Dent Depth of Externally Corroded X65 Gas Pipeline
Authors: Yang Yue , Liu Xiaoben , Yang Hong , Fang Weilun , Chen Pengchao , Li Rui , Gao Hui , Zhang Hong
Published: August 2022

External corrosion dent is a common type of compound dent. On the one hand, this type of compound dent reduces the bearing area and bearing capacity of the pipeline. On the other hand, it leads to an increase in the stress–strain concentration in the dent and reduces the anti-fatigue load capacity of the pipeline, which is more harmful to the service safety of the pipeline than the simple dent. In this study, the reliability of the modeling method was verified by the numerical inversion of the full-size dented pipe test. A three-dimensional finite element model for a pipe with a small corrosion dent was established by analyzing the internal detection data on corrosion defects of pipes with a diameter of 813 mm. The failure criterion of the corrosion dent pipe and the calculation method of the critical dent depth were determined. The influence of corrosion depth, length, width, internal pressure load, curvature radius of indenter, and diameter–thickness pipeline ratio on critical dent depth was investigated. Finally, a critical dent-depth prediction formula was developed based on the numerical results. This study provides a reference and significant guidance for the applicability evaluation of corroded sunken pipelines.
Hydrolysis Behavior and Kinetics of AlN in Aluminum Dross during the Hydrometallurgical Process
Authors: Yang Hong-Liang , Li Zi-Shen , Ding You-Dong , Ge Qi-Qi , Jiang Lan
Published: August 2022

In this study, the hydrolysis behavior and kinetics of AlN in aluminum dross (AD) were investigated in order to better identify the steps controlling the AlN hydrolysis reaction and the factors influencing the hydrolysis rate to enhance the removal efficiency of AlN. The hydrolysis behavior of AlN, including AlN content, phase composition, chemical composition, microstructure, and element distribution, was determined by a leaching test, X-ray diffraction, X-ray fluorescence, scanning electron microscopy, and energy dispersive spectroscopy, respectively. The results showed that increasing the leaching liquid–solid ratio as well as the temperature was helpful for the removal efficiency of AlN. When the liquid-–solid ratio was 4:1, temperature was 90 °C, and leaching time was 300 min, the removal efficiency of AlN reached 89.05%. The kinetics were described using the unreacted core model, and when the temperature was 30–40, 50–70, and 80–90 °C, the hydrolysis reaction rate of AlN was controlled by boundary layer diffusion, chemical reaction control, and product layer diffusion control, respectively.
Controlling Shock-Induced Energy Release Characteristics of PTFE/Al by Adding Oxides
Authors: Yuan Ying , Cai Yiqiang , Shi Dongfang , Chen Pengwan , Liu Rui , Wang Haifu
Published: August 2022

Polytetrafluoroethylene (PTFE)/aluminum (Al)-based energetic material is a kind of energetic material with great application potential. In this research, the control of the shock-induced energy release characteristics of PTFE/Al-based energetic material by adding oxides (bismuth trioxide, copper oxide, molybdenum trioxide, and iron trioxide) was studied by experimentation and theoretical analysis. Ballistic impact experiments with impact velocity of 735~1290 m/s showed that the oxides controlled the energy release characteristics by the coupling of impact velocities and oxide characteristics. In these experiments, the overpressure characteristics, including the quasi-static overpressure peak, duration, and impulse, were used to characterize the energy release characteristics. It turned out that when the nominal impact velocity was 735 m/s, the quasi-static overpressure peak of PTFE/Al/MoO3 (0.1190 MPa) was 1.99 times higher than that of PTFE/Al (0.0598 MPa). Based on these experimental results, an analytical model was developed indicating that the apparent activation energy and impact shock pressure dominated the energy release characteristic of PTFE/Al/oxide. This controlling mechanism indicated that oxides enhanced the reaction after shock wave unloading, and the chemical and physical properties of the corresponding thermites also affected the energy release characteristics. These conclusions can guide the design of PTFE-based energetic materials, especially the application of oxides in PTFE-based reactive materials.
Mechanical and Thermal Stress Analysis of Cervical Resin Composite Restorations Containing Different Ratios of Zinc Oxide Nanoparticles: A 3D Finite Element Study
Authors: Yazdani Negar , Ashrafi Hossein , Özcan Mutlu , Nekoueimehr Negin , Kholdi Mohsen , Farzad Azin
Published: August 2022

Due to an increase in prevalence of cervical lesions, it is important to use appropriate restorative materials to reduce the incidence of secondary lesions. Owing to having antibacterial properties, cervical composite restorations containing different ratios of Zinc Oxide nanoparticles (ZnO NPs) have been analyzed using the Finite Element method to determine the optimal incorporation ratio from mechanical and thermal perspectives. A numerical simulation is conducted for a mandibular first premolar with a cervical lesion (1.5 × 2 × 3 mm3) restored with composites containing 0 to 5% wt. ZnO NPs. Subsequently, the samples are exposed to different thermo-mechanical boundary conditions, and stress distributions at different margins are examined. The accumulated stress in the restoration part increases for the 1% wt. sample, whereas the higher percentage of ZnO NPs leads to the reduction of stress values. In terms of different loading conditions, the least and most stress values in the restoration part are observed in central loading and lingually oblique force, respectively. The change in the surface temperature is inversely correlated with the ratio of ZnO NPs. In conclusion, the composite containing 5% wt. ZnO NPs showed the most proper thermo-mechanical behavior among all samples.
In Situ Observation and Phase-Field Simulation Framework of Duplex Stainless-Steel Slab during Solidification
Authors: Wang Tong , Wexler David , Guo Liangliang , Wang Yangfan , Li Huijun
Published: August 2022

The melting and solidification process of S32101 duplex stainless steel (DSS) was investigated using high-temperature confocal microscopy (HTCM). The method of concentric HTCM was employed to study microstructure evolution during the solidification process of S32101 DSS. This method could artificially create a meniscus-shaped solid–liquid interface, which dramatically improved the quality of in situ observations. During the heating stage, γ-austenite transformed to δ-ferrite, and this transformation manifested itself in the form of grain boundaries (GBs) moving. The effects of cooling rate on the solidification pattern and microstructure were revealed in the present research. An enhanced cooling rate led to a finer microstructure, and the solidification pattern changed from cellular to dendritic growth. As the temperature decreased, the commencement and growth of precipitates were observed. In this paper, the experimental data, including parameters such as temperature, cooling rate, and growth mode, were used as the benchmark for the simulation. A simulation framework using Micress linked to a 1D heat transfer model enabling consistent analysis of solidification dynamics in DSS across the whole cast slab was established. Simulating the dendrite growth and elemental segregation of DSS at specific cooling rates shows that this framework can be a powerful tool for solving practical production problems.
Demonstration of Heterogeneous Structure for Fabricating a Comb-Drive Actuator for Cryogenic Applications
Authors: Xue Gaopeng , Toda Masaya , Li Xinghui , Li Bing , Ono Takahito
Published: August 2022

This study presents an experimental demonstration of the motion characteristics of a comb-drive actuator fabricated from heterogeneous structure and applied for cryogenic environments. Here, a silicon wafer is anodically bonded onto a glass substrate, which is considered to be a conventional heterogeneous structure and is commonly adopted for fabricating comb-drive actuators owing to the low-cost fabrication. The displacement sensor, also with comb-finger configuration, is utilized to monitor the motion characteristics in real time at low temperatures. The irregular motions, including displacement fluctuation and lateral sticking, are observed at specific low temperatures. This can be attributed to the different thermal expansion coefficients of two materials in the heterogeneous structure, further leading to structural deformation at low temperatures. The support spring in a comb-drive actuator is apt to be deformed because of suspended flexible structures, which affect the stiffness of the support spring and generate irregular yield behavior. The irregular yield behavior at low temperatures can be constrained by enhancing the stiffness of the support spring. Finally, we reveal that there are limited applications of the heterogeneous-structure-based comb-drive actuator in cryogenic environments, and simultaneously point out that the material substrate of silicon on the insulator is replaceable based on the homogeneous structure with a thin SiO2 layer.
A Novel Triazole Schiff Base Derivatives for Remediation of Chromium Contamination from Tannery Waste Water
Authors: Alluhaybi Ahmad A. , Alharbi Ahmed , Hameed Ahmed M. , Gouda Ayman A. , Hassen Fatma S. , El-Gendy Hassan S. , Atia Bahig M. , Salem Amany R. , Gado Mohamed A. , Ene Antoaneta , Awad Hamdy A. , Zakaly Hesham M. H.
Published: August 2022

Tannery industries are one of the extensive industrial activities which are the major source of chromium contamination in the environment. Chromium contamination has been an increasing threat to the environment and human health. Therefore, the removal of chromium ions is necessary to save human society. This study is oriented toward the preparation of a new triazole Schiff base derivatives for the remediation of chromium ions. 4,4′-((1E)-1,2-bis ((1H-1,2,4-triazol-3-yl) imino)ethane-1,2-diyl) diphenol was prepared by the interaction between 3-Amino-1H-1,2,4-triazole and 4,4′-Dihydroxybenzil. Then, the produced Schiff base underwent a phosphorylation reaction to produce the adsorbent (TIHP), which confirmed its structure via the different tools FTIR, TGA, 1HNMR, 13CNMR, GC-MS, and Phosphorus-31 nuclear magnetic resonance (31P-NMR). The newly synthesized adsorbent (TIHP) was used to remove chromium oxyanions (Cr(VI)) from an aqueous solution. The batch technique was used to test many controlling factors, including the pH of the working aqueous solution, the amount of adsorbent dose, the initial concentration of Cr(VI), the interaction time, and the temperature. The desorption behaviour of Cr(VI) changes when it is exposed to the suggested foreign ions. The maximum adsorption capacity for Cr(VI) adsorption on the new adsorbent was 307.07 mg/g at room temperature. Freundlich’s isotherm model fits the adsorption isotherms perfectly. The kinetic results were well-constrained by the pseudo-second-order equation. The thermodynamic studies establish that the adsorption type was exothermic and naturally spontaneous.