bluuebunny/crossref_metadata_2025 huggingface dataset:
A hydroxypropiophenone based fluorescent probe for selective determination of Al3+ ions in aqueous ethanol
Authors: Singh Divya Pratap , Singh Chandni , Singh Sunil Kumar , Dwivedi Romi , Singh Ashish Kumar , Singh Vinod Prasad
Published: September 2022

In this work, we had synthesized a novel dihydrazone-based fluorescent probe N'1,N'2-bis{1-(2-hydroxyphenyl)propylidene}oxalohydrazide for Al3+ by simple condensation reaction. The prepared organic probe has been characterized by different physicochemical and spectroscopic techniques. The single-crystal structure of the receptor has also been reported. Aqueous ethanolic solution of probe shows an enhanced fluorescence in the presence of Al3+ ions whereas no appreciable change in spectral pattern is observed in presence of other cations viz. Na+, K+, Ca2+, Ba2+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Cr3+, Cd2+ and Hg2+. The binding mode of the receptor with Al3+ was studied by various spectral titration techniques such as UV-visible, fluorescence and 1H NMR. The receptor acts as a dibasic hexadentate ligand and interacts with two Al3+ ions with a high binding constant KB = 8.99 × 1010 M− 1. The lowest detection limit for the Al3+ complex of H2hpoh was determined to be 7.8 × 10− 5 M. With the help of DFT calculation, the mechanism of fluorescence enhancement has been explained.
Effect of hemicellulose extraction on the solution properties of cellulose carbamate in NaOH/ZnO aqueous system
Authors: Shang Jiaoping , Wang Junmei , Li Yibao , Peng Yun , Li Xingxing , Zhou Jinping , Xu Dingfeng
Published: September 2022

Hemicellulose removal from bleached bamboo pulp is the key to produce of qualified dissolving pulps. In this work, the alkali/urea aqueous solution was applied to improve the hemicellulose removal efficiency of bleached bamboo pulp. The removal rate of hemicellulose was affected by urea usage, time and temperature. The removal rate of hemicellulose achieved 70.14% in 6 wt% NaOH/1 wt% urea at 40°C for 30 min. After esterification by urea method of the pulp, the dissolution behavior of cellulose carbamate (CC) pulp with different DP, hemicellulose and N contents were studied, and the highest solubility was up to 97.7%. The effect of hemicellulose content on the stability and solubility of CC solution was subsequently analyzed by polarizing microscope and rheology. With a decrease of hemicellulose from 15.9, 8.60 to 5.70%, the gel temperature increased from 59.0, 69.0 to 73.4°C. The apparent gelation time increases from 5640 to 12120 s with the hemicellulose decreased from 15.9 to 8.60%, and HC-5.70 always keeps a liquid-state (G'' > G') until the test time reach 17000 s. The results showed that the removal hemicellulose, reduce DP and increasing esterification endow CC solution with higher solubility and stability.
An Evaluation of Vascular Density Changes by Optical Coherence Tomography Angiography in Patients with Ocular Hypertension
Authors: Çomçalı Sebile , Yılmaz Pınar Topçu , Köz Özlem Gürbüz , Coşkun Çiğdem , Çavdarlı Cemal , Yarangümeli Alper , Özdemir Emine Yıldız
Published: September 2022

Purpose
To evaluate Optical Coherence Tomography Angiography (OCT-A) findings in patients with Ocular Hypertension (OHT) and compare them with healthy individuals.
Material and Methods
Thirty-four patients with ocular hypertension (OHT) and 22 healthy individuals were included in the study. Foveal thickness, retinal vascular density in superficial and deep capillary plexus and choriocapillaris, foveal avascular zone (FAZ), acircularity index (AI), foveal vessel density (FD), non-flow area, capillary and all vessel densities in the peripapillary area and the disc were automatically measured using the Angiovue software of OCT-A and compared between groups.
Results
The comparison of the macular OCT-A findings did not reveal a significant difference between the two groups in terms of central macular thickness, superficial and deep capillary plexus vessel density (p > 0.05). The foveal avascular zone width was significantly higher in OHT patients compared to the control group (0.30 ± 0.08µ and 0.25 ± 0.11 µ, respectively; p = 0.04). The comparison of optic nerve OCT-A findings revealed that the whole-field vessel density (wVD) (p = 0.007), peripapillary vessel density (pVD) (p = 0.001), inferior, superior and temporal radial peripapillary capillary plexus vessel density (p = 0.006, p = 0.008, p = 0.02) and the mean retinal nerve fiber layer thickness (p = 0.02) were significantly lower in the OHT group.
Conclusion
Our findings suggest that the decrement in the optic disc vascular density and foveal avascular zone width was significantly higher in OHT patients. The possible effect or role of these microvascular changes in terms of glaucoma development should be examined through further studies.
Effects of Jacalin- a galactose binding lectin on MDA-MB-468, a triple-negative breast cancer cell line, and its combinatorial effect with taxol
Authors: Kumar Bommanaboina Anil , Waseem Mohammad , Jamal Shazia , Ahmed Neesar
Published: September 2022

Plant lectins have been well established to show the affect on the proliferation in different human cancer cells. The anti-proliferative potential of lectins have been ubiquitously investigated from diverse sources and, the basic mechanism has been explored in an elaborated index. In our study, we observed anti-proliferative efficacy of Jacalin (a purified lectin from jackfruit (Artocarpus integrifolia) seeds in MDA-MB-468, a triple-negative breast cancer cell line. This effect was explored in a dose dependent manner. The cells were treated with Jacalin at different time points (6hr and 12hr) and thereafter the recovery in cell propagation was also observed after which the jacalin media was aspirated. Thus, Jacalin was considered as to possess reversible effects on MDA-MB-468 cells. On the other side, Jacalin did not pose the effect in proliferation cascade in PBMCs, taken as primary cell line control. Galactose is well recognized ligands of Jacalin and its pre-incubation could neutralize the effect. Furthermore, MDA-MB-468 cells were also treated with Jacalin in combination with increasing concentration of taxol, keeping jacalin concentration constant (40µg/ml). Taxol at the concentration of 930 nM in combination with jacalin achieved the similar kind of anti-proliferative effect that was observed with 30 µM of taxol. Thus the taxol concentration could be reduced if given in combination of jacalin, preventing the side effect of taxol due to higher dose.
Whole-Brain Structure-Function Coupling Abnormalities in Mild Cognitive Impairment: A Study Combining ALFF and VBM
Authors: Zhao Rong , Wang Pan , Zhang Fanyu , Hu Peng , Wen Jiaping , Li Hongyi , Biswal Bharat B.
Published: September 2022

Background
Alzheimer's disease, one of the most leading nervous system diseases, is accompanied by symptoms including loss of memory, thinking, and language ability. Both mild cognitive impairment (MCI) and very MCI (VMCI) are the transitional pathological stage between normal ageing and AD. While the changes to whole-brain structural and functional information have been extensively investigated in AD, the impaired structure-function coupling within whole brain remains unknown.
Methods
Current study employed the OASIS-3 dataset including 53 MCI, 90 VMCI and 100 age-, gender- and education-matched normal controls (NC). Several structural and functional parameters including amplitude of low frequency fluctuations (ALFF), voxel-based morphometry and ALFF/VBM ratio analysis were used to estimate the whole-brain abnormalities among MCI, VMCI and NC.
Results
As the disease symptoms became more severe, these regions distributing in the cerebellum and putamen within gray matter exhibited progressively increasing ALFF (ALFFNC < ALFFVMCI < ALFFMCI). Similar results were also found in the frontal-inf-orb, putamen, and paracentral-lobule within white matter. More importantly, as the symptoms of disease got worse, parahippocampal gyrus and hippocampus within gray matter showed progressively decreasing structure-function coupling, and was also applicable to the cuneus and frontal lobe within WM. In addition, the structure-function coupling values in the parahippocampal gyrus and hippocampus were positive relationship with severity of cognitive impairment, suggesting the important applications of the structure-function coupling index in brain disorders.
Conclusion
Our findings provided a novel information for discovering the pathophysiological mechanisms and indicated that WM lesions were also an important cause of cognitive decline in AD.
Geochemical precursory characteristics of soil gas related to the 2019 Xiahe Ms5.7 earthquake across the northern margin of West Qinling fault zone,Central China
Authors: Zhou Huiling , Li Zongxing , Su Hejun , Li Chenhua , Wan Yue
Published: September 2022

The Xiahe Ms5.7 earthquake occurred on October 28, 2019, and was located within the national earthquake priority hazard zone designated as of 2019. We use the mobile observation data of soil gases Rn, Hg, H2, and CO2 from 2016 to 2019 of 11 profiles in the northern margin of the West Qinling fault zone, combining the sturdy body seismogenic model and numerical simulation results to investigate the spatial and temporal evolution characteristics of the cross-fault soil gas before the Xiahe Ms5.7 earthquake. This research showed that the seismic activity of the northern margin of the West Qinling fault zone varies significantly among the secondary fault zones, and the overall state is that the middle east section’s activity is weakened toward the west section, which has good coupling with the spatial distribution characteristics of the fault soil gas in this fault zone. The soil gas concentration intensity across the northern margin of the West Qinling fault zone showed a clear decreasing trend from HT1 to HT4 in the western section, which is the closest segment to the Xiahe Ms5.7 earthquake fault, and a turning up after a continuous decrease in Rn in HT1 and Hg and CO2 in HT2, and Rn, CO2, and Hg in HT4. The other measurement lines in the middle east section did not show similar precursor features. The decline characteristic of fault gas tectonic geochemistry is a good indicator of the interlocked section of fracture tectonic activity. The sturdy body seismogenic model can explain the relationship between the tectonic geochemical characteristics and the rupture locking, and it has theoretical support for determining the time, space, and intensity of seismogenesis. Strengthening the research on seismic models, obtaining a physical model that is “close to reality,” and generating a comprehensive and unified interpretation of the precursor field under the guidance of certain models is a practical approach for earthquake prediction and forecasting in the future. It is easy to make mistakes in terms of the location if we do not identify the mechanism. Thus, it is crucial to strengthen the flow monitoring and seismogenic model research of the deep fluids in the fracture zone.
Wildfire exerts a long-term impact on soil multifunctionality by influencing soil environments and vegetation regeneration in a Chinese boreal forest
Authors: Kong Jianjian , Yu Yue , Xiang Xingjia , Yang Jian
Published: September 2022

Background and aims
Wildfires can trigger significant changes in soil functioning in boreal forests, and fire-caused changes in soil environments and vegetation community can further affect soil functioning. However, the response of multiple simultaneous soil functions (i.e. multifunctionality) to wildfire and postfire changes in soil environments and regeneration vegetation remains unknown though soil multifunctionality (SMF) is crucial to the biogeochemical cycling and plant growth.
Methods
We sampled 60 soils at unburned control, 1-year-postfire, and 11-year-postfire sites in a Chinese boreal larch forest to explore the relationships between SMF and fire severity, bacterial diversity, soil environments and regenerated vegetation.
Results
The SMF was lower at the two burned sites relative to the control, decreasing with increased fire severity but increasing with soil bacterial diversity. Structural equation modeling analysis confirmed that fire severity was the most important predictor of SMF at the 1-year-postfire site, while SMF at the 11-year-postfire site was mainly mediated by soil moisture besides fire severity, regenerated tree density and grass cover.
Conclusions
Wildfire exerts a long-term negative effect on SMF and this effect is closely related to fire severity and bacterial diversity in the Great Xing’an Mountains. The effects of wildfire on SMF might be directly mediated by fire severity in the short term but indirectly by altering soil environments and vegetation regeneration in the long term. We conclude that increasing fire severity of these forests can both directly decrease SMF and trigger the degradation of their soil-plant ecosystems, which would further imperil the maintenance of SMF.
E2F1 activation by oncogenic FLT3 internal tandem duplication in regulating purine metabolism in acute myeloid leukaemia
Authors: Chen Feihu , Ou Zi-yao , Wang Ke , Shen Wenwen , Deng Ge , Xu Yayun , Wang Longfei , Zai Zhuoyan , Ling Yian , Zhang Tao , Peng Xiaoqing
Published: September 2022

Oncogene FLT3 internal tandem duplication (FLT3-ITD) mutation account for up to 30% of acute myeloid leukaemia (AML) cases and induce transformation.Previously, we found that E2F transcription factor 1 (E2F1) is involved in autophagy in the AML cell line MOLM-13, which harboring the FLT3-ITD. Here, we reported that E2F1 expression was gradually decreased during normal haematopoiesis but was aberrantly upregulated in AML patients carrying FLT3-ITD. E2F1 knockdown in cultured FLT3-ITD-positive AML cells inhibited cell proliferation and increased their cellular sensitivity to all-trans retinoic acid (ATRA) and its derivative 4-amino-2-trifluoromethyl-phenyl resinate (ATPR). Moreover, E2F1-depleted FLT3-ITD+ AML cells lost their malignancy as shown by the reduced leukaemia burden and prolonged survival in leukemic NOD-PrkdcscidIl2rgem1/Smoc mice. Additionally, FLT3-ITD-driven transformation of human CD34+ haematopoietic stem and progenitor cells (HSPCs) was counteracted by E2F1 knockdown. Mechanically, the expression and nuclear accumulation of E2F1 were highly dependent on FLT3-ITD activity. Further study using chromatin immunoprecipitation-sequencing and metabolomics analyses revealed that ectopic FLT3-ITD promoted the recruitment of E2F1 on genes encoding key enzymatic regulators of purine metabolism and thus supported AML cell proliferation. Together, this study demonstrates the dependence of FLT3-ITD+ AML cells on E2F1-regulated purine metabolism, and provides a promising therapeutic strategy for AML patients.
Authoritarian Leadership and Nurse Presenteeism: The Role of Workload and Leader Identification
Authors: Shan Geyan , Wang Wei , Wang Shengnan , Zhang Yongjun , Guo Shujie , Li Yongxin
Published: September 2022

Background:Nurses’ health in the workplace is crucial for ensuring the quality of healthcare. However, presenteeism, the behavior of working in a state of ill health, is widespread in the nursing industry. Considering that the origin of authoritarian leadership and the prevalence of presenteeism are inseparable from Chinese workplace culture, this study aimed to explore the impact and mechanism of authoritarian leadership on presenteeism.Methods:A total of 528 nurses were recruited from four 3A-grade hospitals in the present survey, which was distributed across 98 nursing teams. Participants were required to complete self-report measures on authoritarian leadership, presenteeism, workload, and leader identification. Description, correlation, and multilevel linear regressions were applied for data analysis.Results:The present study found that presenteeism was significantly related to participants’ demographic characteristics, such as marital status, educational level, technological title, and general health. There was a positive relationship between authoritarian leadership and presenteeism, and workload acted as a mediator in authoritarian leadership and presenteeism. Furthermore, leader identification moderated the relationship between authoritarian leadership and workload. When nurses were under high leader identification, the positive impact of authoritarian leadership on workload was reinforced.Conclusions:This study revealed the potential antecedents and mechanisms of nurse presenteeism from the perspective of workplace culture. Results indicated that the excessive authoritarianism of leaders and the heavy workload faced by nurses may be the significant triggers for nurses' presenteeism. The role of leader identification is not always protective, which may heighten the relationship between dark leadership and its outcomes. These observations contribute to enriching research on presenteeism and authoritarian leadership, and provide valuable insights for cultivating healthy working behaviors.
Transformation of multi-source results to the front line of experimental teaching
Authors: Cong Jianchao , Xu Shengnan , Wang Hui , Li Ke , Liu Jun , Wan Jing , Wang Jingwei , Liu Yanhong , Wu Junzhu
Published: September 2022

Background
Multiple sources such as university students' research and innovation projects, some of the teachers' research projects suitable for teaching practice, existing teaching experiments and literature, etc. Integrating the experimental results of morphology, functional and molecular biology and other disciplines into further experimental teaching mode can better integrate basic experimental skills with clinical development, meet the development needs of students and solve the problem of insufficient comprehensive basic teaching experiments, etc. It will further strengthen students' comprehensive application ability, overall thinking ability, practical hands-on ability, and analytical and adaptive ability.
Methods
A questionnaire on "Evaluation of existing basic medicine integrated experiments" was distributed to faculty members and undergraduate students in the School of Basic Medicine. Based on the results of the questionnaire, we propose to use multi-source projects as the original resources for the design of integrated experiments, design innovative integrated experiments covering multiple disciplines and meeting the needs of teaching and development of undergraduates by undergraduate volunteers in open laboratories, and evaluate the feasibility of the results of multi-source to the front line of experimental teaching through the evaluation form.
Results
Through feasibility assessment, the comprehensive experiments of basic medicine designed based on multi-source results have the characteristics of high comprehensiveness and feasibility, which can be transformed to the front line of experimental teaching.
Conclusions
Through this model, the aim is to achieve comprehensive integration of basic medical laboratory courses, to keep the laboratory courses abreast of cutting-edge achievements in the field, and to cultivate students' interest in and thinking about scientific research.
Partial Mesorectal Excision Can Be a Primary Option for Middle Rectal Cancer: A Propensity-score Matched Retrospective Analysis
Authors: Kim Ee Jin , Kim Chan Wook , Lee Jong Lyul , Yoon Yong Sik , Lim Seok-Byung , Park In Ja , Yu Chang Sik , Kim Jin Cheon
Published: September 2022

Backgrounds
Although partial or total mesorectal excision (PME and TME) is primarily indicated for the upper and lower rectal cancer, respectively, few studies have evaluated whether partial or total mesorectal excision (PME or TME) is more optimal for middle rectal cancer.
Methods
This study included 671 patients with middle/upper rectal cancer who underwent robot-assisted PME or TME. The two groups were optimized by propensity-score matching of sex, age, clinical stage, tumor location, and neoadjuvant treatment.
Results
Complete mesorectal excision was achieved in 617 (92%) of 671 patients, without showing difference between the PME and TME groups. Local (5.3% vs 4.3%, p = 1) and systemic (8.5% vs 16%, p = 0.181) recurrence rates also did not differ between the two groups, respectively, in patients with middle/upper rectal cancer. A comparison of the PME and TME groups with middle rectal cancer showed no significant differences in 5-year DFS (81.4% vs 74%, p = 0.537) and OS (88% vs 81.1%, p = 0.847) rates. Moreover, 5-year recurrence and survival rates were not affected by distal resection margins of 2–4 cm (p = 0.112–1), regardless of pathological stages. Postoperative complication rate was higher in the TME than in the PME group (21.4% vs 14.5%, p = 0.027). Incontinence was independently associated with TME (odds ratio [OR] = 2.009; 95% confidence interval = 1.015–3.975; p = 0.045), along with older age (OR = 4.366) and prolonged operation time (OR = 2.196) (p < 0.001–0.5).
Conclusions
PME can be primarily recommended for patients with middle rectal cancer with lower margin > 5 cm from the anal verge.
Secure Transmission with Different Security Requirements Based on Covert Communication and Information-Theoretic Security in Presence of Friendly Jammer
Authors: Baee Pooya , Khodadad Farid Samsami , Forouzesh Moslem
Published: September 2022

In this paper, we investigate joint information-theoretic security andcovert communication on a network in the presence of a single transmit-ter (Alice), a friendly jammer, a single untrusted user, two legitimateusers, and a single warden (Willie). In the considered network, one of theauthorized users, Bob, needs a secure communication, and therefore hismessage must be sent securely, and at the same time, the other autho-rized user, Carol, needs covert communication, i.e., the existence of hiscommunication with the transmitter should not be detected by the war-den, Willie. In the proposed network model, it is assumed that for covertcommunication requirements, Alice will use an on-off strategy to sendthe data to the legitimate receivers of the network, so that it decides onthe sending of data at any specific time slot. One of the main challengesin covert communication is low data rate because we have to reduce thetransmission power such that the main message gets to hide in back-ground noise. In the proposed network, a jammer is employed to destroy the eavesdropper and warden’s channel. To eliminate the interferencecreated by the jammer, it has been proposed that the used jammer in thenetwork be friendly. In this study, in addition to using joint security ofinformation theory and covert communication, we examine the averagetransmission rate according to the limitations and requirements of covertcommunication and the requested quality of service by users, by creatingartificial noise in the network which is generated by a friendly jammer.
Earthquake Risk Scenario for Commercial Masonry Infill Buildings in the Auckland Region of New Zealand
Authors: Fikri Rijalul , Gerstenberger Matt , Ingham Jason
Published: September 2022

Following the 2010/2011 Canterbury, New Zealand earthquake sequence, Auckland Council actively identified and assessed commercial buildings within the Auckland region to establish whether they were earthquake-prone. Masonry infill buildings were one class of building type that was considered to be potentially earthquake-prone, with this building type constituting a significant proportion (9%) of all commercial buildings in the Auckland region. Despite the Auckland region being categorised as a low seismicity region in the current New Zealand seismic loadings standard, rupture of the Wairoa North fault located within the Auckland region could potentially generate significant earthquake shaking in the future. The reported study was undertaken to forecast the damage distribution for low-rise and mid-rise masonry infill buildings when subjected to ground motions from the Wairoa North fault that incorporated a combined mainshock-aftershock earthquake sequence. The results showed that mid-rise masonry infill buildings were forecast to exhibit significant damage when compared to low-rise masonry infill buildings. In addition, the seismic risk associated with mid-rise masonry infill buildings buildings was forecast to significantly increase when aftershock earthquake scenarios were applied. It is noted that the increased seismic risk of mid-rise masonry infill buildings (when compared to their low-rise equivalent) was unsurprising because post-earthquake observation following the Canterbury earthquake sequence showed that mid-rise masonry infill buildings sustained higher levels of damage in comparison to low-rise masonry infill buildings.
The effects of pro-, pre- and synbiotics supplementation on polycystic ovary syndrome: an umbrella review of meta-analyses of randomized controlled trials
Authors: Talebi Sepide , Zeraattalab-Motlagh Sheida , Payandeh Nastaran , Jalilpiran Yahya , Ansari Shakila , Mohammadi Hamed , Djafarian Kurosh , Ranjbar Mahsa , Sadeghi Sara , Taghizadeh Mahdiyeh , Shab-Bidar Sakineh
Published: September 2022

Background
Numerous meta-analyses of randomized clinical trials have proven that pro, pre- and synbiotics supplementation have numerous health outcomes in women with polycystic ovary syndrome (PCOS). However, the strength and quality of this evidence in aggregate not yet been synthesized in great detail.
Methods
PubMed, Scopus, Web of Sciences, and Google Scholar were searched up to August 2022. We pooled the mean difference and its 95% confidence interval (CI) by applying a random-effects model.
Results
Overall, eight meta-analyses including a total of 12 trials were identified. The results of the present study indicated that probiotic supplementation significantly reduced the homeostatic model assessment for insulin resistance (HOMA-IR) (WMD: -0.29, 95% CI: -0.57 to -0.02, P = 0.03, n = 4; moderate certainty) and fasting glucose concentration (WMD: -7.5 mg/dl, 95% CI: -13.60 to -0.51, P = 0.03; n = 4; low certainty). Moreover, synbiotic supplementation had beneficial effects on glycemic control, lipid profile, and hormonal parameters, but the certainty of the evidence was rated as low to very low. However, supplementation with pro-/synbiotics did not affect inflammation and oxidative stress in women with PCOS. Furthermore, waist/hip circumference, fasting glucose concentration, lipid profile, dehydroepiandrosterone sulfate, high-sensitivity C-reactive protein, and hirsutism score were significantly reduced after prebiotics supplementation with low certainty of evidence.
Conclusions
Although pro-, pre- and synbiotics supplementation had beneficial effects on some PCOS-related outcomes, the certainty of the evidence was rated as low to very low. Therefore, further well-designed RCTs might help to confirm our findings in women with PCOS.
Intra and Inter Body Area Network Communication System for Out- of-hospital Nursing of Pcos Patients by Coupling Medical Big Data Mining With Cloud
Authors: Saravanabhavan C. , Preethi P. , Anguraju K. , Ashok P.
Published: September 2022

Hospital admissions, readmissions, and other cost of healthcare are significantly impacted by the growing number of patients with chronic conditions and the accumulation of healthcare resources. The hormonal imbalance PCOS produced in women in their reproductive years also contributes to a number of chronic ailments, including irregular periods, excessive weight gain, acne, and the growth of facial hair etc. A delayed or missing menstrual cycle brought on by the hormonal imbalance results in infertility. The current approaches and therapies are insufficient for earlier stage diagnosis, especially from their home-centric environment. Till date, no technology has been able to independently identify the presence of PCOS in the ovaries which eventually affects fallopian tube and alert the patient, consulting doctor, or nurse so that the next course of action can be started as soon as possible. Hence, to solve the aforementioned issues, the proposed research processes the information gathered from PCOS patients using a cloud computing platform integrated with medical big data mining and machine learning (ML) algorithms. In this study, a conceptual design is proposed from the perspective of communications engineering. In order to detect Fallopian Tube (FT) activity, the architecture combines an intra-body-based nano-sensor with a body-area network. This network receives data from the intra-body networking and transmits it across the air to the relevant personnel (doctor, nurse, patients). The relationship between feasible information rates, and other key metrics has been investigated through preliminary simulations utilising a particle oriented stochastic simulator. Data from sensor are utilised by the Apache Kafka acts as ingestion tool, then given into cloud service computing architecture wherein Advanced Apriori (AA) algorithm is applied over the data to detect characteristics featuring with strong correlations between them before undergoing CatBoost Decision Tree model for optimised prediction of PCOS. The comparison analysis demonstrates notable results in terms of scalability and computation times with an ideal accuracy range.
Analysis of the fracture line distribution of distal radius fractures
Authors: Zhang Xin , Xie Pinliang , Shao Weirong , Xu Ming , Yin Yong , Fan Jian , Zhang Yingqi
Published: September 2022

Objective To study the general distribution of fracture lines in distal radius fractures (DRFs).
Methods Computed tomography scans from 50 patients with DRFs were included in this study. The DICOM data of all patients were analyzed using Mimics 20.0 software, and the bone blocks were marked with different colors after the surrounding related bones were removed. After reduction of the fracture, 3-matic software was used to plot 50 fracture lines on the same standardized bone structure of the distal radius. Finally, a heat map was developed based on the frequency of the fracture lines.
Results Although the fracture lines varied widely in DRFs, most fracture lines were regularly distributed. In the metaphyseal region of the distal radius, the width of the ring was 4.52 mm, and the ring was located in the region of primary epiphyseal cartilage development below the watershed. Fractures below the annular band were occasional. The distribution of volar fracture lines above the annular band was significantly less than that of dorsal fracture lines, which was more concentrated in the area around the Lister tubercle and more involved in the distal radioulnar joint.
Conclusion The fracture lines were regularly distributed in the distal radius with a ring-shaped high-incidence zone.
Investigation of potential tea polyphenols against SARS-CoV-2 targets: A Computational approach
Authors: Vinayagan Nadana , Singh Gurmeet
Published: September 2022

The global pandemic of COVID-19 caused by SARS-CoV-2 (also known as 2019-nCoV and HCoV-19) has affected many countries worldwide. Emerging strains of SARS-CoV-2 exhibit dynamic genomic and structural patterns gradually, where the development of a suitable vaccine has become more challenging. Identification of novel compounds that control the viral replication and viral prophylaxis mechanism would be a potential option to stop the spread of infection. Tea, a common beverage in Asia, possessing an abundance of anti-oxidative properties, is used commonly in households. Polyphenols from tea are known to be beneficial in several functional aspects of health. In the present study, using high throughput computational integrative approaches, we understand the application of lead polyphenols from tea against five known viral targets of SARS-CoV-2. From the phylogenetic analysis of the viral targets, whole-genome sequences of SARS-CoV-2 shared the highest nucleotide similarity (> 90%) with 8 other beta SARS viruses, including SARS-CoV-2 recent strains, SARS-CoV and MERS-CoV. The ADMET evaluation of the tea compounds showed favorable drug-likeness, and pharmacokinetics properties, with less toxicity profiles. Finally, the molecular docking indicated grazoprevir may represent as a potential treatment option, and strictinin, epigallocatechin 3,3',-di-o-gallate, epicatechin 3,5-di-o-gallate, gallocatechin 3'-o-gallate, epitheaflagallin, theaflavin-3-gallate, epitheaflagallin 3-o-gallate, rutin and tannic acid could potentially inhibiting to the SARS-CoV-2 targets by possessing significant binding affinities (− 12.6 to − 5.1 kcal/mol). Thus, these potent tea compounds effectively interrupt the viral replication cycle and may reduce or eradicate the expeditious outspreading of SARS-CoV-2.
ICA69 deficiency exacerbates the inflammation on liver injury associated with distinct alteration in the gut microbiota
Authors: 项 伟玲 , Hao Ke , Tao Fei , Xu Weide , Chen Bingyu , Cheng JingJing , Zhang Wei , Wang Dan , Wang Zhen , Du Yaoqiang , Li Kaiqiang , Lyu Jianxin , Jin Liqin
Published: September 2022

Hepatitis is a major problem around the worlds, which is characterized by hepatic inflammation and intestinal gut microbiome imbalance. Our previous study has been provided that Islet-cell autoantigen 69(Ica69) plays a central role in liver injury and found that both Ica69 mRNA and protein are significantly upregulated in mouse hepatocytes at the early stage of liver regeneration. In this study, we found that Ica69-deficient mice have more severe liver injury than wild-type mice (WT) by intraperitoneal injection of D-galactosamine (D-GalN) combined with lipopolysaccharide (LPS)(DL injection). Analysis of serum biochemical indexes and histology revealed an increment in hepatic inflammation in the Ica69-deficient group. And we also found that Ica69 deficiency exacerbated the gut microbiome imbalance, including the reduction of probiotics, Lactobacilli, Bifidobacteria and Bacteroides, and the increment of conditional pathogens, Proteobacteria,in the intestine.Mechanistically,Ica69 deficiency upregulated the expression of inflammation-related (IL-17 and IL-22) genes expression and toll-like receptor 4(TLR4)/tumor necrosis factor (TNF-a ) pathway. We conclude that Ica69 mediates liver inflammation and the intestinal microbial disorder caused by D-GalN combined with LPS induced acute liver injury, indicating that Ica69 in protection against immune-associated liver injury and providing a theoretical foundation for treating liver disease.
A comparison of depression, anxiety and related factors in Chinese First-born and Second-born children
Authors: Yuan QinMei , Yang Shichang , Yang Huan , Cao YuPing , Morgan Timothy
Published: September 2022

Background
The status of depression, anxiety and related factors in Chinese firstborn and second-born children have hitherto not been examined and remains unknown. With the changing of China’s fertility policy, it is of greater significance to know about children’s health growth.
Methods
A convenience sampling and cross-sectional survey method was used. Data was collected from school-based sample in one middle and one primary school located in Xinxiang City, Henan province in China during the period February 18th to March 22nd 2019. There was a total of 653 first-born and 772 second-born children in the surveyed data pool. Depression self-rating scale for children (DSRSC), Screen for Child Anxiety Related Emotional Disorders (SCARED), Perceived parental rearing patterns scale, Chinese Screen Questionnaire of Child Abuse were used.
Results
Second-born child was in higher risk to suffer from anxiety when compared with first-born child(P < 0.05). The depression score of female was significantly higher compared to males in the second-born child (P < 0.05). The anxiety score of female was significantly higher compared to males in both the firstborn and second-born children (Ps < 0.05 − 0.01), while the anxiety score of female was significantly higher in the second-born compared to whom in firstborn child (P < 0.05). People who with elder female siblings were of lower depression and anxiety scores than other with male siblings(Ps < 0.05 − 0.01). Age gap was weakly negatively correlated with the depression scores of the first-born children(P < 0.05). The mean scores of severe punishment, excessive interference and overprotection from father were higher in males in both firstborn and second-born children (Ps < 0.001), rejection/denial in firstborn from father were higher in males in second-born child. The mean scores of over interference and over protection from mother were also higher in males in both firstborn and second-born children (Ps < 0.05 − 0.001).
Conclusions
The second-born children are more likely to suffer from depression and anxiety, especially in female. The related factors including the age gap, the gender of elder siblings, the parenting styles and the child abuse. It suggested that under China’s fertility policy, more energy needs to be devoted to maintaining children's mental health.
A smart hybrid content defined chunking algorithm for data deduplication in cloud storage
Authors: E Manogar , S Abirami
Published: September 2022

The enormous growth of data requires a large amount of storage space in the cloud server, which occupies mostly by the redundant data. The deduplication technique avoids redundancy to utilize cloud storage effectively. Chunking is the process to break the data into chunks, determine duplicates. Many algorithms exist, to handle the deduplication efficiency, reducing the chunk variance, and improving the computational overhead continues to be a challenging task. To solve the above challenge, we propose a Smart Chunker (SC) algorithm, which operates with hybrid chunking based on file size as File Level and Content Defined Chunking (CDC). File-level Chunking is assigned only for less than 2KB file size, and the exceeding file size falls with CDC. We aim Optimus Prime Chunking (OPC) in CDC to break the chunks with prime numbers and involves a minimum number of comparisons with fewer conditions and low computation overhead. This work reduces the processing time without hash and window for computation. Thus, it provides a constant average chunk size to distribute the equal chunk variance in the cloud storage with a 17% reduction in chunk time. Our OPC result attains high throughput of more than 3.3x, compared to other CDC algorithms.
Sustainable ordering policies with capacity constraint under order-size dependent trade credit, all-units discount, carbon emission and partial backordering
Authors: Mahato Chandan , Mahata Gour Chandra
Published: September 2022

In today's competitive business situation, the supplier frequently offers his or her retailers a permissible delay period to stimulate sales. In addition, the capacity of any warehouse is limited in practice, thus the retailer needs an additional rented warehouse to store the excess units when the order quantity exceeds the capacity of the own warehouse. Furthermore, with the globalization of the marketing policy, the supplier may provide the retailer a discounted price if the quantity of purchase is large enough. Green inventory management reduces the environmental impacts of a business without lacking its profit. Considering all of the factors mentioned above, in this paper we study a green economic order quantity model with capacity constraint under order-size dependent trade credit and all-units discount along with minimizing carbon for a cleaner environment. The paper discusses all the potential cases, which may occur in green inventory models with carbon emission cost under different allowable delay-in-payments. Shortages are allowed and partially backordered. The major objective is to determine the sustainable optimal ordering strategies for retailers, and whether the retailer needs an additional rented warehouse such that the retailer’s annual profit is maximized. First, we prove that the conditions of the objective functions have interior minimizer value and the closed-form optimal solution is found. Next, an algorithm is developed to determining the global optimal solution of the problem. Finally, some numerical examples are presented to illustrate theoretical results. Sensitivity analysis of the major parameters is performed and some insights are obtained.
Prediction model of hot strip crown based on industrial data and hybrid PCA-SDWPSO-ELM approach
Authors: Wang Zhenhua , Liu Yuanming , Wang Tao , Gong Dianyao , Zhang Dianhua
Published: September 2022

The accurate prediction of strip crown is the precondition of the shape pre-set model in hot strip rolling. In this study, a new data-driven model of strip crown based on extreme learning machine (ELM) optimized by S-curve decreasing inertia weight PSO (SDWPSO) algorithm and industrial data is proposed. In order to simplify the model structure and save modeling time, principal component analysis (PCA) is used to reduce the dimension of the input data for modeling samples. The comprehensive performance of the proposed hybrid PCA-SDWPSO-ELM prediction model is evaluated by several error indexes. The superiority of the proposed model is also proved by comparing the prediction results with other three comparison models. The research shows that the hybrid PCA-SDWPSO-ELM method can solve the problem of nonlinear and strong coupling in the traditional engineering. It is suitable for the parameters prediction and optimization of the iron and steel manufacturing industry, especially in the process of shape control in hot strip rolling.
Redefining Engineering Education as Skill Training
Authors: Higgs Bryan
Published: September 2022

The year 2020 has forced many institutions to suddenly convert wholly to online education as necessitated by a global pandemic. Online education introduces a physical distance between the instructor and the students that creates many barriers to learning in traditional lecture-style teaching. However, the rapid shift to online learning has opened many minds to the value of online educational tools from both the instructor's and student's points of view. For engineering education, the value of online learning can be increased through the adoption of a new perspective that engineering is a skill. Students who graduate from engineering programs are valued for 12 key skills: (1) problem-solving, (2) computer science, (3) industry skills, (4) pressure management, (5) teamwork, (6) creativity, (7) structural analysis, (8) communication, (9) attention to detail, (10) educational commitment, (11) data modeling, and (12) leadership. Possession of these skills has even led to many engineering graduates being recruited outside of the field of engineering due to the value they offer. With the true value of graduates being the skills they possess, it stands to reason that the curriculum of engineering programs should be designed for the development of these skills. By adjusting the curriculum through the use of repeated attempts on assignments and quizzes, students can be prompted to increase their investment in courses and thus improve the skills they develop. Offering immediate feedback through the use of online tools can further improve skill development by highlighting shortfalls to students so they can adjust accordingly before engaging in their next attempt. Redefining engineering education as a skill development offers the opportunity to take advantage of the current online learning situation to create new learning environments that are more optimized for the production and development of skillful engineers that are highly valued in the workforce.
String correlators on $\text{AdS}_3$: Analytic structure and dual CFT
Authors: Dei Andrea , Eberhardt Lorenz
Published: September 2022

We continue our study of string correlators on Euclidean
\text{AdS}_3AdS3
with pure NS-NS flux. The worldsheet and spacetime correlators have a
rich analytic structure, which we analyse completely for genus 0
four-point functions. We show that correlators exhibit a simple
behaviour near their singularities. The spacetime correlators are
meromorphic functions in the \mathrm{SL}(2,\mathbb{R})SL(2,ℝ)-spins,
whose pole structure is shown to agree with the prediction of a recent
proposal for the dual \text{CFT}_2CFT2.
Moreover, we also compute the residues of the spacetime correlators for
some of the poles exactly and find again a perfect match with the
proposal for the dual \text{CFT}_2CFT2,
thereby checking the duality for some non-trivial four-point functions
exactly. Our computations simplify drastically in the tensionless limit
of \mathrm{AdS}_3 \times \mathrm{S}^3 \times \mathbb{T}^4AdS3×S3×𝕋4
where the behaviour near the poles gives in fact the exact answer. This
paper is the third in a series with several installments.
Quantum Field Theory Anomalies in Condensed Matter Physics
Authors: Arouca Rodrigo , Cappelli Andrea , Hansson Hans
Published: September 2022

We give a pedagogical introduction to quantum anomalies,
how they are calculated
using various methods, and why they are important in condensed matter
theory. We discuss axial, chiral, and gravitational anomalies as well
as global anomalies. We illustrate the theory with examples
such as quantum Hall liquids, Fermi liquids, Weyl semi-metals,
topological insulators and topological superconductors. The required
background is basic knowledge of quantum field theory, including
fermions and gauge fields, and some familiarity with path integral and
functional methods. Some knowledge of topological phases of matter is
helpful, but not necessary.
Violencia misógina, amor y patriarcado
Authors: Grajales Usuga Martha Elena
Published: September 2022

Hay un acuerdo generalizado en las disciplinas humanísticas en comprender la misoginia tal y como lo indica su etimología: odio a las mujeres. El objetivo de este artículo es hacer una revisión crítica de este uso del concepto de misoginia y proponer un sentido más preciso del mismo. Este ejercicio de clarificación conceptual se compone de tres partes. Primero, se evidencia que las motivaciones que desencadenan las reacciones misóginas no son siempre originadas por el odio, en algunos casos están entretejidas con amor o afecto. Segundo, se subraya la estrecha relación de la misoginia con el patriarcado y así se muestra que esta es esencialmente un fenómeno político más que una patología psiquiátrica o una tendencia psicogénetica exclusiva de los hombres. Por último, se señala que la misoginia es un mal moral porque se sustenta en juicios falsos y demandas irracionales de bienes morales que dañan gravemente la dignidad de las mujeres y que son amparadas por el mismo sistema patriarcal. Se concluye que el desplazamiento de la misoginia del campo de lo psicogenético al campo político y moral hace posible comprenderla como un fenómeno más cotidiano y recurrente, y como un mal sociopolítico que debe combatirse de manera colectiva.
A comparative study of the time of concentration methods for designing urban drainage infrastructure
Authors: Mehta Osheen , Kansal Mitthan Lal , Bisht Deepak Singh
Published: September 2022

The time of concentration (ToC) is an important parameter in rainfall−runoff simulation for designing and evaluating an urban drainage system (UDS). There are several lumped and distributed methods available in the literature for estimating the ToC. However, these methods lead to significantly varied values. Therefore, it is imperative to choose an appropriate and best-suited method for estimating the ToC. This study analyses eight lumped approach-based and two distributed approach-based methods for estimating the ToC in an urban area of Gurugram, a satellite city in the National Capital Region (NCR) of Delhi in India. Considering the ToC obtained by the Natural Resource Conservation Service (NRCS) method as the ‘true’ value, the Carter method among lumped methods and the SWDM method between the distributed methods results in ToC values in agreement with the NRCS method. Furthermore, to study the impact of the underestimation or overestimation of ToC on drainage, the system is evaluated in terms of variation in flood volume, duration, peak discharge, and the time to peak for different ToC values. The simulations were carried out by setting the model in SWMM, and it was found that flood volume increases by 4.25 times and the duration increases by 7.25 times if the ToC is increased from 0.1 to 6.14 h. The results infer that ToC estimation methods significantly impact the design and performance of an urban drainage infrastructure.