bluuebunny/crossref_metadata_2025 huggingface dataset:
Pruritus, Pain, and Depression Associated with the Most Common Skin Diseases: Data from the French Study “Objectifs Peau”
Authors: Huet Flavien , Taieb Charles , Corgibet Florence , Brenaut Emilie , Richard Marie-Aleth , Misery Laurent
Published: September 2021

Background: The prevalence and impact of pruritus, pain, and other sensory symptoms in skin diseases are poorly known. Objective: To assess the frequency of these symptoms with dermatoses and their association with depression using data from the “Objectifs Peau” survey. Methods: A representative sample of 20,012 French individuals was created using the usual quota method. Results: When patients suffered from both pruritus and skin pain, they had a higher relative risk of psychological suffering (2.9) than those who suffered only from pruritus (1.4) or skin pain (1.2). Pruritus was reported in 48.55% of patients with acne, 43.24% with mycoses, 44.35% with warts, and 36.51% with rosacea. For skin pain, the results were 11.22%, 27.59%, and 16.13% for atopic dermatitis, acne, and warts, respectively. Other unpleasant sensations, such as tingling or burning, were also frequently reported. Conclusion: Pruritus, pain, or other sensory symptoms were found to be common not only in classic pruritic skin diseases but also in acne, rosacea, or warts. The association of pruritus and pain dramatically increased psychological suffering. These symptoms must be systematically searched for in patients, especially since new therapeutic possibilities are emerging for the symptomatic treatment of pruritus.
Characteristics and Laboratory Findings of Food-Induced Anaphylaxis in Children: Study in an Asian Developing Country
Authors: Nantanee Rapisa , Suratannon Narissara , Chatchatee Pantipa
Published: September 2021

Introduction: Food allergy is the major cause of pediatric anaphylaxis. Characteristics and triggers may be different in different geographical regions. Studies focusing on food-induced anaphylaxis (FIA) in Asian developing countries are limited. Our study aimed to study characteristics of FIA in a tertiary care center in an Asian developing country. Methods: Retrospective review of pediatric anaphylaxis admission and outpatient visit at a tertiary care hospital in Bangkok, Thailand during 2008–2018 was performed. Data regarding clinical presentation, place reaction occurred, time of onset, investigations (serum tryptase, specific immunoglobulin E, and skin test), treatment, and follow-up periods were collected. Results: One hundred seventy-four anaphylaxis admission records of which 61 episodes of FIA were retrieved. Data from outpatients visit consisted of 17 patients. Most patients were male (76.7%). The median age was 7.1 years (interquartile range 1.9–12.4). The major causes of FIA were shrimp/shellfish (37%), wheat (15.1%), and cow’s milk (11%). Food causing anaphylaxis varied according to age-group: infants had anaphylactic reactions to egg, wheat, and cow’s milk, preschools to wheat and peanut, and older children to shrimp/shellfish. Cutaneous manifestations occurred in all patients, followed by lower respiratory tract symptoms (83.6%) and gastrointestinal symptoms (50.8%). There was no biphasic anaphylaxis reported. Elevated serum tryptase was found in only 4 patients (7%). Conclusion: Recognizing characteristics of pediatric FIA is crucial. The common causes of FIA in our study in Asian children were egg in infants, wheat and peanut in preschool children, and shrimp/shellfish in school-age children and adolescents. Skin manifestation presented in all patients with FIA.
Evaluating Primary Care Providers’ Readiness for Delivering Genetic and Genomic Services to Underserved Populations
Authors: Sharma Yashoda , Cox Livia , Kruger Lucie , Channamsetty Veena , Haga Susanne B.
Published: September 2021

Introduction: Increased genomics knowledge and access are advancing precision medicine and care delivery. With the translation of precision medicine across health care, genetics and genomics will play a greater role in primary care services. Health disparities and inadequate representation of racial and ethnically diverse groups threaten equitable access for those historically underserved. Health provider awareness, knowledge, and perceived importance are important determinants of the utilization of genomic applications. Methods: We evaluated the readiness of primary care providers at a Federally Qualified Health Center, the Community Health Center, Inc. (CHCI) for delivering genetic and genomic testing to underserved populations. Online survey questions focused on providers’ education and training in basic and clinical genetics, familiarity with current genetic tests, and needs for incorporating genetics and genomics into their current practice. Results: Fifty of 77 (65%) primary care providers responded to the survey. Less than half received any training in basic or clinical genetics (40%), were familiar with specific genetic tests (36%), or felt confident with collecting family health history (44%), and 70% believed patients would benefit from genetic testing. Conclusion: Despite knowledge gaps, respondents recognized the value and need to bring these services to their patients, though would like more education on applying genetics and genomics into their practice, and more training about discussing risk factors associated with race or ethnicity. We provide further evidence of the need for educational resources and standardized guidelines for providers caring for underserved populations to optimize appropriate use and referral of genetic and genomic services and to reduce disparities in care.
What Is the Interaction between Urine C-Reactive Protein, Prostatic Inflammation, and Doxazosin Treatment in Patients with Benign Prostatic Hyperplasia? A Pilot Study
Authors: Asfuroglu Ahmet , Balci Melih , Aslan Yilmaz , Senel Cagdas , Guzel Ozer , Kilinckaya Muhammed Fevzi , Turhan Turan , Tuncel Altug
Published: September 2021

Introduction: It was aimed to show the relationship between benign prostatic hyperplasia and inflammation by measuring urinary C-reactive protein values before and after alpha-blocker treatment. Methods: A total of 71 patients with a total prostate-specific antigen <3.5 ng/mL, International Prostate Symptom Score >7, and maximum urinary flow rate <15 mL/s were included in the study. Doxazosin 4 mg p.o. once daily was started orally as an alpha-blocker treatment. Serum and urine C-reactive protein values, International Prostate Symptom Score, maximum urinary flow rate, and the post-void residual volume of patients were recorded at the first admission and in the first month of alpha-blocker treatment. Results: The mean age of the patients was 59.2 ± 7.5 years. The mean serum C-reactive protein values of the patients at the first admission and follow-up were 2.62 ± 1.8 (range, 0–5) mg/L and 2.83 ± 1.6 (0–6) mg/L, respectively. The mean urine C-reactive protein values of the patients at the first admission and follow-up were 0.45 ± 0.11 (range, 0.28–0.99) mg/L and 0.14 ± 0.04 (range, 0.79–0.328) mg/L, respectively, which was statistically significantly different. In the subgroup analysis, the urine C-reactive protein level change was more prominent in severely symptomatic patients than in moderately symptomatic patients. Conclusion: Our results showed that C-reactive protein was detectable in urine, alpha-blocker treatment significantly reduced urine C-reactive protein levels, and the decrease was more prominent in severely symptomatic patients.
Prevalence and Biological Correlates of Oropharyngeal Dysphagia in Outpatients of a Geriatric Evaluation Clinic: A Brief Report
Authors: Ambrosio-Palma Abdias , Avila-Funes Jose Alberto , Mimenza-Alvarado Alberto , Serralde-Zúñiga Aurora Elizabeth , Zavala-Solares Mónica , Aguilar-Navarro Sara
Published: September 2021

Background: Oropharyngeal dysphagia (OD) is a relevant disease among older adults and is associated with serious adverse health-related outcomes, such as malnutrition, sarcopenia, or frailty. Increasing its recognition and the related mechanisms will allow us to its prevention and treatment at different levels of care. Objectives: This study aimed to determine the prevalence and biological correlates of OD in outpatient older adults. Method: This is a cross-sectional study including 100 adults aged 60 or older from a geriatric clinic of a tertiary hospital in Mexico City. Health variables and geriatric syndromes were recorded. The Eating Assessment Tool-10 detection test and the volume-viscosity swallowing test were used to diagnose OD. Logistic regression models were performed to identify the factors associated with OD. Results: Mean age was 81.2 (±7.5) years and 21% had OD. The presence of xerostomia (p = 0.05) and a worst nutritional status (p = 0.035) were obtained. Conclusions: The prevalence of OD among older adults was high. Inadequate nutrition status and the presence of xerostomia are more likely to be present with this swallowing disorder.
Raman Spectrum-Based Diagnosis Strategy for Bladder Tumor
Authors: Liu Zhenghong , Zhang Pu , Wang Heng , Zheng Bin , Sun Li , Zhang Dahong , Fan Jinhai
Published: September 2021

Raman spectroscopy is an optical technique that can potentially serve as a molecular diagnosis method. This approach is excellent in many aspects for diagnosing bladder tumors, and over the last 20 years, there has been a rapid increase in the number of related studies. However, no review article has covered the wide use of Raman spectroscopy in bladder tumors. A total of 26 original studies have suggested that Raman spectroscopy shows good performance in diagnosing bladder tumors from 4 aspects, including tissue sections, endoscopic methods, cell screening, and biomarkers. However, Raman spectroscopy needs to be modified by combining it with other techniques, and studies based on a large population are still urgently needed to expand its clinical value.
Atrial Fibrillation in Aging and Frail Mice
Authors: Jansen Hailey J. , Moghtadaei Motahareh , Rafferty Sara A. , Rose Robert A.
Published: September 2021

Background:

Atrial fibrillation is prevalent in aging populations; however, not all individuals age at the same rate. Rather, health status during aging can vary from fit to frail. Frailty can be quantified using a frailty index (FI). Natriuretic peptides modulate atrial function in part by activating NP (natriuretic peptide) receptor C (NPR-C). The impacts of NPR-C on atrial structure and arrhythmogenesis in aging and as a function of frailty are unknown.

Methods:

Frailty was measured in aging wildtype and NPR-C knockout (NPR-C
−
/−
) mice. Atrial structure and function were studied using intracardiac electrophysiology in anesthetized mice, high-resolution optical mapping in intact atrial preparations, histology, and molecular biology.

Results:

NPR-C
−/−
mice had a shortened lifespan and more rapidly became frail compared with wildtype mice. Atrial fibrillation burden and P wave duration were increased in older versus younger wildtype mice and further increased in older NPR-C
−/−
mice; however, there was substantial variability among age groups and genotypes. P wave duration was strongly correlated with FI score regardless of age or genotype. Optical mapping of the atria demonstrated reduced conduction velocity and changes in action potential duration that were also graded by FI score. Atrial fibrosis was increased in aged and NPR-C
−/−
mice and was strongly correlated with FI score. Atrial fibrosis was associated with changes in expression of profibrotic genes, including MMPs (matrix metalloproteinases), TIMPs (tissue inhibitors of metalloproteinases), and TGFβ (transforming growth factor β). Gene expression changes were also correlated with FI scores.

Conclusions:

NPR-C plays an essential role in the aging-dependent decline in health status as well as alterations in atrial function and arrhythmogenesis. Frailty assessment is a highly effective approach for identifying age-dependent heterogeneity in atrial structure and function, including in the setting of shortened lifespan because of loss of NPR-C.
Transitions in Metabolic Health and Associations With Arterial Stiffness Progression Across Body Mass Index Categories
Authors: Wu Shouling , Song Lulu , Wang Lulin , Chen Shuohua , Wu Mingyang , Wang Youjie , Tian Yaohua
Published: September 2021

Metabolically healthy obesity is an unstable state and its transition to a metabolically unhealthy phenotype confers an increased risk of cardiovascular disease. However, it remains unclear whether changes in metabolic health over time are associated with arterial stiffness progression, a key player in the pathophysiology of cardiovascular disease. We aimed to investigate the associations of changes in metabolic health across body mass index categories with arterial stiffness and its progression. This study included 22 153 participants without cardiovascular disease or cancer at baseline from the Kailuan Study. Arterial stiffness was assessed using brachial-ankle pulse wave velocity at baseline and repeated after a mean follow-up of 3.1 years. Changes in metabolic health across body mass index categories were evaluated between the first survey (2006–2007) and the first brachial-ankle pulse wave velocity measurement. Multivariate linear regression models were used. Among initial metabolically healthy obese individuals, 53.4% (n=928) converted to a metabolically unhealthy phenotype. Compared with metabolically healthy normal-weight individuals who remained metabolically healthy, metabolically healthy obese individuals who converted to a metabolically unhealthy phenotype showed a 110.7 (95% CI, 90.8–130.6) cm/s higher increase in baseline brachial-ankle pulse wave velocity and a 22.8 (95% CI, 12.4–33.2) cm/s per year higher acceleration in arterial stiffness progression. Individuals who were initially metabolically unhealthy or converted so during follow-up across body mass index categories had higher baseline brachial-ankle pulse wave velocity and arterial stiffness progression than those who remained metabolically healthy. These data suggest that metabolically healthy individuals who develop an unhealthy phenotype across all body mass index categories are at increased risks of arterial stiffness and its progression.
Negative Influence of Insufficient Sleep on Endothelial Vasodilator and Fibrinolytic Function in Hypertensive Adults
Authors: Stockelman Kelly A. , Bain Anthony R. , Goulding Anabel , DeSouza Noah M. , Rahaman Clay , Maly Lukas , Greiner Jared J. , Stauffer Brian L. , DeSouza Christopher A.
Published: September 2021

Insufficient nightly sleep (<7 hour/night) has been linked to the cause of hypertension and is a prevalent, often ignored, comorbidity. We tested the hypotheses that chronic nightly insufficient sleep is associated with lower nitric oxide-mediated endothelium-dependent vasodilation and endothelial tPA (tissue-type plasminogen activator) release in hypertensive adults; and that the insufficient sleep-related reduction in endothelial vasodilator and fibrinolytic function is due to increased oxidative stress. Fifty hypertensive adults were studied: 20 with normal nightly sleep duration (14M/6F; age: 59±2 year; blood pressure: 138/83±1/1 mm Hg; sleep: 7.6±0.1 hour/night) and 30 with short nightly sleep duration (21M/9F; 56±1 year; 138/84±2/1 mm Hg; 5.8±0.1 hour/night). Forearm blood flow (plethysmography) was determined in response to intraarterial infusion of: acetylcholine in the absence and presence of N
G
-monomethyl-L-arginine and the antioxidant vitamin C; bradykinin in the absence and presence of vitamin C; and sodium nitroprusside. Endothelial release of tPA was determined in response to bradykinin without and with vitamin C. Vasodilation to acetylcholine was significantly lower (≈20%) in the short versus normal sleep adults. N
G
-monomethyl-L-arginine reduced (≈25%;
P
<0.05) acetylcholine vasodilation in the normal but not short sleepers. Vitamin C increased (≈35%;
P
<0.05) acetylcholine vasodilation in short sleepers only. Endothelial tPA release to bradykinin was significantly lower (≈25%) in the short versus normal sleep duration adults. Co-infusion of vitamin C induced greater tPA release in short sleepers. In hypertensive adults, insufficient sleep is associated with reduced nitric oxide–mediated endothelium-dependent vasodilation and endothelial tPA release. These sleep-related abnormalities in endothelial function are due, in part, to oxidative stress.
Exploring Scientific Inquiry via Agent-Based Modelling
Authors: Šešelja Dunja
Published: September 2021

In this paper I examine the epistemic function of agent-based models (ABMs) of scientific inquiry, proposed in the recent philosophical literature. In view of Boero and Squazzoni’s (2005) classification of ABMs into case-based models, typifications and theoretical abstractions, I argue that proposed ABMs of scientific inquiry largely belong to the last category. While this means that their function is primarily exploratory, I suggest that they are epistemically valuable not only as a temporary stage in the development of ABMs of science, but by providing insights into theoretical aspects of scientific rationality. I illustrate my point with two examples of highly idealized ABMs of science, which perform two exploratory functions: Zollman’s (2010) ABM which provides a proof-of-possibility in the realm of theoretical discussions on scientific rationality, and an argumentation-based ABM (Borg et al. 2019, 2017b, 2018), which provides insights into potential mechanisms underlying the efficiency of scientific inquiry.
Lost Years Recovered John Peters and Phillis Wheatley Peters in Middleton
Authors: Dayton Cornelia H.
Published: September 2021

A cache of Essex County legal papers reveals that when Phillis Wheatley Peters and her husband left Boston in 1780, they moved to Middleton where John became a landowner on a farm where he had been enslaved. I analyze the racial, class, and gender conflicts that led to their eviction.
Monitoring the phenology of Forsythia velutina, an endemic plant of Korea
Authors: Sung Jung-Won , Kim Geun-Ho , Lee Kyeong-Cheol , Shim Yun-Jin , Kang Shin-Gu
Published: September 2021

Background and objective This study was conducted on Forsythia velutina, a special plant, in Gyeongsangnam-do Arboretum under the Gyeongsangnam-do Forest Environment Research Institute, which is located in the southern part of Korea. Methods The research aimed to analyze the flowering characteristics of the plant by calculating the optimal temperature and humidity according to the flowering time and flowering period for 8 years from 2010 to 2017 in order to provide basic data for bioclimate studies of endemic plants. Results It was observed that the Forsythia velutina showed a life cycle from mid-March and to mid-November. Average growth period was 243 (± 6.5) days. In testing the reliability of a single variable according to the meteorological factors, the Cronbach’s Alpha was 0.701, which indicates that the findings were relatively reliable. The average date of flowering was March 16 (SD = 5.8) and the average date on which blossoms fall was March 29 (SD = 5.2). A substantial difference in flowering period was observed from year to year 11 to 23 days, with an average of 16 days (± 4.7). The temperature and humidity in February to March, which affect the flowering, were 2.9–5.5°C, and 66.5–73.0%, respectively, and showed differences every year. Conclusion The correlation between flowering time and meteorological factors was positive, and the highest daily temperature and average daily temperature had the highest significance. When establishing basic data on plant species for the conservation of endemic plants, the changes in life cycle events and weather conditions are identified. It is believed that it will be helpful in establishing a conservation strategy for the plant species in the future.
Analysis of the Correlation Between Ecological Status and Location Environment by Cultivated Land Restoration Type of Geumgang Riverine Ecobelt
Authors: Lee Soo-Dong , Back Seung-Jun , Kang Hyun-Kyung
Published: September 2021

Background and objective The purpose of this study is to investigate the ecological status of six areas around Geumgang River that used to be farmlands before they were restored as a riverine ecobelt. This study aims to analyze the correlation between the location environment and ecological status of the sites to identify the environmental factors affecting them. Methods The sites are classified into four types according to restoration: terraced paddy fields, flat paddy fields, artificial wetland, and landscape forest. The survey items were divided into land use status, plant ecology, and animal ecology. Results In terms of plant ecology, terraced paddy fields showed favorable naturality with the rate of native species above 90% and the naturalization index below 10%. In terms of animal ecology, the total number of species found in these areas was biggest in terraced paddy fields, followed by flat paddy fields, artificial wetland, and landscape forest. Regarding species diversity, terraced paddy fields also showed abundant species with an average of 1.05 to 1.09. The results of the correlation analysis showed that the forest area around the sites had the most significant effect on species diversity. The grassland and open water area showed a positive correlation with the total number of animal species and the number of dragonflies, confirming that the marshy grassland had a positive effect. As the cultivated land and urbanized area around the sites increased, it had a negative effect on the distribution of native species and the number of animal species that appeared, and a positive effect on the naturalization index. Conclusion It is necessary to establish preemption and restoration plans for sites such as grasslands adjacent to the forest and terraced paddy fields in order to promote resilience of the diverse species returning to the purchased lands.
Aggression towards neonates and possible infanticide in the boto, or Amazon river dolphin (Inia geoffrensis)
Authors: da Silva V.M.F. , Silva P.M. , Schlichta F. , do Carmo N.A.S. , Olson G.L. , Hintermayer B.G. , Araujo M.C. , Martin A.R.
Published: September 2021

Recent observed attacks by male Amazon river dolphins on conspecific calves, together with post-mortem examinations, indicate that infanticide occurs in this species but that not all attacked calves are killed. If mortality occurs, it might therefore be an inadvertent consequence of the behaviour rather than the motive for it. Our observations suggest that males who commit infanticide are unlikely to gain direct fitness benefits. Evidence does not fit the sexual selection hypothesis. Aggression towards calves usually ‘drew a crowd’ and may represent socio-sexual display or simply be a form of social pathology, as found in other infanticidal mammals.
Transfer of the monospecific genus Nienburgella (Delesseriaceae, Rhodophyta) to Phycodrys, based on morphological and molecular evidence
Authors: KANG JEONG CHAN , LEE HYUNG WOO , KIM MYUNG SOOK
Published: September 2021

The genus Phycodrys is characterized by having a Phycodrys-type apical organization, a well-developed central midrib with paired lateral veins, monostromatic areas between the veins, four-celled carpogonial branches with two groups of sterile cells, and a cystocarp with a large fusion cell and short-catenated carposporangia. In contrast, the monospecific genus Nienburgella has a faint midrib, a mostly polystromatic blade without lateral veins, bilaterally isometric second-order cell row length, and Phycodrys-like apical growth and cystocarp. Nothing is known about Nienburgella’s procarp. We collected several specimens of Nienburgella angusta from the East Sea of South Korea and noticed that they resemble Phycodrys radicosa. We compared these two species using morphological and molecular phylogenetic analyses. Our results revealed that both species are closely related to one another than to other taxa in the tribe Phycodryeae, and that Nienburgella angusta procarp developmental pattern is the same as the one observed in Phycodrys rubens, the generitype species of Phycodrys. Thallus structure (mono- or polystromatic) was species-delimiting but not genus-delimiting. Bilateral second-order cell row isometry occurs in other Phycodrys species, including the type species. Therefore, we propose transferring the species Nienburgella angusta as well as the monospecific genus Nienburgella to Phycodrys.
New species and records of Anchocerus Fauvel in China (Coleoptera: Staphylinidae: Staphylininae)
Authors: LIN XIAO-BIN , HU JIA-YAO
Published: September 2021

Two species of Anchocerus Fauvel are reported from China, one of them described as new: A. wenxuani Lin & Hu, sp. n. (Guangxi). Anchocerus giganteus Hu, Li & Zhao, 2010 is newly recorded from Shanghai, Jiangxi, Guangxi and Guangdong. A map showing the distribution of all Chinese species is provided.
Taxonomic position of Heissothignus and review of the species of Meschia (Hemiptera: Heteroptera: Meschiidae)
Authors: MALIPATIL M. B. , YESHWANTH H. M. , KONDOROSY ELŐD
Published: September 2021

The New Guinean genus Heissothignus Slater & Brailovsky, 2006 (Hemiptera: Heteroptera: Meschiidae) possesses several morphological characters unique to family Meschiidae but not occurring in Heterogastridae, confirming its placement within the family Meschiidae. A key to the genera of the family Meschiidae is presented. The two species of the genus Meschia Distant, 1910 recorded from the Indian subcontinent are reviewed, and the following new synonymy is proposed: M. pugnax Distant, 1910 = M. quadrimaculata Distant, 1910, syn. nov. A revised key to the species of Meschia is provided. New country and state records are provided for M. pugnax (India: Andhra Pradesh, Karnataka, Meghalaya, Rajasthan, Tamil Nadu and Uttarakhand), Meschia barrowensis Malipatil, 2014 (Australia: New South Wales) and Meschia zoui Gao & Malipatil, 2019 (Thailand).
A 30-Year Climatology (1990–2020) of Aerosol Optical Depth and Total Column Water Vapor and Ozone over Texas
Authors: Mims Forrest M.
Published: September 2021

A 30-yr time series (4 February 1990–4 February 2020) of aerosol optical depth (AOD) of the atmosphere, total precipitable water (TPW), and total column ozone has been conducted in central Texas using simple, highly stable instruments. All three parameters in this ongoing measurement series exhibited robust annual cycles. They also responded to many atmospheric events, including the historic volcanic eruption of Mount Pinatubo (1991), a record El Niño (1998), an unprecedented biomass smoke event (1998), and La Niña that caused the driest drought in recorded Texas history (2011). Reduced air pollution caused mean AOD to decline from 0.175 to 0.14. The AOD trend measured for 30 years by a light-emitting diode (LED) sun photometer, the first of its kind, parallels the trend from 20 years of measurements by a modified Microtops II. While TPW responded to El Niño–Southern Oscillation conditions, TPW exhibited no trend over the 30 years. The TPW data compare favorably with 4.5 years of simultaneous measurements by a nearby NOAA GPS (r2 = 0.78). The 30 years of ozone measurements compare favorably with those from a series of NASA ozone satellites (r2 = 0.78). In 2016, 194 comparisons of Microtops II and world standard ozone instrument Dobson 83 at the Mauna Loa Observatory agreed within 1.9% (r2 = 0.81). The paper concludes by observing that students and citizen scientists can collect scientifically useful atmospheric data with simple sun photometers that use one or more LEDs as spectrally selective photodiodes.
Using Radio Occultation to Detect Clouds in the Middle and Upper Troposphere
Authors: Mascio Jeana , Leroy Stephen S. , d’Entremont Robert P. , Connor Thomas , Kursinski E. Robert
Published: September 2021

Radio occultation (RO) measurements have little direct sensitivity to clouds, but recent studies have shown that they may have an indirect sensitivity to thin, high clouds that are difficult to detect using conventional passive space-based cloud sensors. We implement two RO-based cloud detection (ROCD) algorithms for atmospheric layers in the middle and upper troposphere. The first algorithm is based on the methodology of a previous study, which explored signatures caused by upper tropospheric clouds in RO profiles according to retrieved relative humidity, temperature lapse rate, and gradients in log-refractivity (ROCD-P), and the second is based on inferred relative humidity alone (ROCD-M). In both, atmospheric layers are independently predicted as cloudy or clear based on observational data, including high performance RO retrievals. In a demonstration, we use data from 10 days spanning seven months in 2020 of FORMOSAT-7/COSMIC-2. We use the forecasts of NOAA GFS to aid in the retrieval of relative humidity. The prediction is validated with a cloud truth dataset created from the imagery of the GOES-16 Advanced Baseline Imager (ABI) satellite and the GFS three-dimensional analysis of cloud state conditions. Given these two algorithms for the presence or absence of clouds, confusion matrices and receiver operating characteristic (ROC) curves are used to analyze how well these algorithms perform. The ROCD-M algorithm has a balanced accuracy, which defines the quality of the classification test that considers both the sensitivity and specificity, greater than 70% for all altitudes between 6 and 10.25 km.
Digital analysis of tooth sizes among individuals with different malocclusions: A study using three-dimensional digital dental models
Authors: Karadede Ünal Beyza , Dellaloğlu Deniz
Published: September 2021

Objective:

It is aimed to examine the tooth sizes of digital models of patients with different malocclusions with the help of three-dimensional measurement software.

Methods:

Digital models of 252 patients aged between 13 and 25 years of age were included. According to the Angle classification, three different malocclusion groups were allocated such that there were 84 patients in each group, plaster models of patients scanned with the three-dimensional model browser 3Shape R700 3D Scanner (3Shape A/S Copenhagen, Denmark) and transferred to the digital format. 3Shape Ortho Analyzer (3Shape A/S Copenhagen, Denmark) software was used for making the necessary tooth size measurements.

Results:

When the measurements were evaluated, it was determined that significant changes occurred between tooth sizes of individuals with different malocclusions. Generally, higher values were observed in mesiodistal and buccolingual tooth dimensions of class II individuals compared to other groups. There was no difference between the groups in the anterior ratio values, but when the overall ratio values were evaluated among the groups, a statistically significant difference was determined. Class II malocclusion group was found to have a significantly lower overall ratio of occurrence.

Conclusion:

Individuals with different malocclusions differ in tooth size.
Study on flow resistance characteristics of SiC foam ceramics
Authors: Chen Shuai , Su Shan , Zhang Yanping , Zhang Shuhao , Peng Shini
Published: September 2021

Porous media combustion has significant advantages of high thermal efficiency and low pollution emissions. However, the flow state in the porous media will affect the reaction rate. In order to increase the rate of chemical reactions, the fluid flow resistance in the porous media must be reduced. The pressure drop test of SiC foam ceramics was carried out. By changing the pore density of the experimental materials, the pressure drop characteristics of SiC foam ceramic are tested and analyzed. Based on the classical Ergun equation, a semi-empirical formula for calculating the pressure drop gradient of SiC foam ceramics with the airflow velocity is proposed. The two constants in the formula are calculated by measurement, and the applicability of the formula is verified. This formula can quickly analyze the pressure drop characteristics of SiC foam ceramic materials. The accurate measurement of pressure drop is helpful to determine the rated pressure of the head of foam ceramic burner and reduce the investment of front-end fans in industrial burners.
“Let’s Not Have the Perfect Be the Enemy of the Good”: Social Impact Bonds, Randomized Controlled Trials, and the Valuation of Social Programs
Authors: Williams James W.
Published: September 2021

This article uses the case of “social impact bonds” (SIBs) to explore the role of social science methods in new markets in “social investment.” Pioneered in the UK in 2010, SIBs use private capital to fund social programs with governments paying returns for successful outcomes. Central to the SIB model is the question of evaluation and the method to be used in determining program outcomes and investor returns. In the United States, the randomized controlled trial (RCT) has been the dominant method. However, this has not been without controversy. Some SIB practitioners and investors have argued that, while this may be the perfect tool, the need to grow the SIB market demands a more pragmatic approach. Drawing from a three-year study of SIBs, and informed by Science and Technology Studies (STS)-inspired work on valuation and the social life of methods, the article explores RCTs as both a valuation technology central to SIB design and the object of a micropolitics of valuation which has impeded market growth. It is the relationship between, and the politics of, evaluation and valuation that is a key lesson of the SIB experiment and an important insight for future research on “social investment” and other settings where methods are constitutive of financial value.
Predictors of Success After Furlow Palatoplasty for Repair of Cleft Palate: Does Syndrome Matter?
Authors: Evans Sean S. , Bly Randall A. , Paulsgrove Kaylee , Perkins Jonathan A. , Sie Kathleen
Published: September 2021

Objective

To determine predictors of success following Veau 1 and 2 cleft palate repair in patients with and without syndromes.

Study Design

Retrospective review of prospectively collected data.

Setting

Tertiary care children’s hospital.

Methods

All children <18 months of age undergoing Furlow palatoplasty for Veau 1 and 2 cleft repair between 2000 and 2014 with postoperative perceptual speech assessment (PSA).

Results

In total, 368 consecutive patients were identified; 95 were excluded, resulting in 273 patients. Median age at surgery was 13.0 months (interquartile range [IQR], 11‐15 months) with postoperative PSA at a median of 32.3 months (IQR, 26.3‐44.5 months). Fifty patients (18.3%) had syndrome diagnosis; 59 patients (21.6%) had nonsyndromic Robin sequence. Velopharyngeal insufficiency (VPI) occurred in 27 patients (10.5%); 13 underwent secondary speech surgery. Cleft‐related speech errors occurred in 46 patients (17.6%). Non‐cleft‐related speech errors occurred in 155 patients (59.6%) and reduced intelligibility in 127 patients (47.9%). Oronasal fistula occurred in 23 patients (8.8%) and was exclusive to Veau 2 clefts. In multivariate analysis, age >13 months at palatoplasty demonstrated a 6‐fold higher rate of VPI (hazard ratio [HR], 6.64; P <. 01), worse speech outcomes (HR, 6.04; P <. 01; HR, 1.60; P <. 01; HR, 1.57; P =. 02), and greater speech therapy utilization (HR, 2.18; P <. 01).

Conclusion

VPI occurred in 10% of patients undergoing Furlow palatoplasty repair of Veau 1 or 2 clefts. Age <13 months at palatoplasty was associated with improved speech outcomes and lower VPI incidence (2.8% vs 16.2%). Syndromic diagnosis was associated with noncleft speech errors and reduced intelligibility on univariate analysis but not velopharyngeal function after palatoplasty.
Connected while apart: Associations between social distancing, computer-mediated communication frequency, and positive affect during the early phases of COVID-19
Authors: Shufford Kevin N. , Hall Deborah L. , Randall Ashley K. , Braunstein Bailey M. , O’Brien Mary M. , Mickelson Kristin D.
Published: September 2021

The COVID-19 pandemic has fundamentally altered life for individuals worldwide. Specifically, at the time of data collection (late April 2020), most forms of face-to-face interactions were limited and, in some cases, prohibited, as close contact with others increases the rate of transmitting the virus. As social beings, engaging in social distancing may have negative consequences on well-being. However, many individuals maintained their social connections by means of computer-mediated communication (CMC), such as hosting FaceTime happy hours or family reunions. Utilizing a nationally representative sample of 985 adults from the United States, this study investigated the association between social distancing adherence and positive affect and the extent to which this association might be mediated by CMC frequency. Results did not indicate a direct effect of social distancing adherence on positive affect. However, an indirect effect between these two variables occurred when mediated by CMC frequency. Specifically, greater social distancing adherence predicted greater frequency of CMC, which predicted greater positive affect. These findings held controlling for age, gender, race/ethnicity, relationship status, and income. Results suggest that despite social distancing, CMC may be a beneficial way to engage with others during and, perhaps, beyond COVID-19.
Asian patients’ perspectives on advance care planning: A mixed-method systematic review and conceptual framework
Authors: Martina Diah , Geerse Olaf P , Lin Cheng-Pei , Kristanti Martina S , Bramer Wichor M , Mori Masanori , Korfage Ida J , van der Heide Agnes , Rietjens Judith AC , van der Rijt Carin CD
Published: September 2021

Background:

Asian healthcare professionals hold that patients’ families play an essential role in advance care planning.

Aim:

To systematically synthesize evidence regarding Asian patients’ perspectives on advance care planning and their underlying motives.

Design:

Mixed-method systematic review and the development of a conceptual framework (PROSPERO: CRD42018099980).

Data sources:

EMBASE, MEDLINE, Web of Science, and Google Scholar were searched for studies published until July 27, 2020. We included studies concerning seriously-ill Asian patients’ perspectives on advance care planning or their underlying motives for engaging or not engaging in it.

Results:

Thirty-six articles were included; 22 were quantitative and 27 were from high-income countries. Thirty-nine to ninety percent of Asian patients were willing to engage in advance care planning. Our framework highlighted that this willingness was influenced not only by their knowledge of their disease and of advance care planning, but also by their beliefs regarding: (1) its consequences; (2) whether its concept was in accordance with their faith and their families’ or physicians’ wishes; and (3) the presence of its barriers. Essential considerations of patients’ engagement were their preferences: (1) for being actively engaged or, alternatively, for delegating autonomy to others; (2) the timing, and (3) whether or not the conversations would be documented.

Conclusion:

The essential first step to engaging patients in advance care planning is to educate them on it and on their diseases. Asian patients’ various beliefs about advance care planning should be accommodated, especially their preferences regarding their role in it, its timing, and its documentation.
A multi-agent-based for fault location in distribution networks with wind power generator
Authors: Azeroual Mohamed , Boujoudar Younes , Aljarbouh Ayman , El Moussaoui Hassan , El Markhi Hassane
Published: September 2021

The integration of distributed generation (DG) units such as wind power into the distribution network are one of the most viable technique to meet the energy demand increases. But, the integration of these DG units into power systems can change the dynamic performances of the systems and create new challenges that are necessary to be taken care of in the operation of the network. The fault location and diagnosis are the most significant technical challenges that can improve power systems’ reliability and stability. In this paper, a Multi-Agent System (MAS) based on current amplitude and current direction measured proposed for fault location, isolation, and power restoration in a smart distribution system with the presence of a wind power generator. The agents can communicate and collaborate to locate the faulted line, then send trips signal to corresponding circuit breakers accordingly. The simulation results show the performance of the proposed techniques.
Capacity Gains of Splitting Cross-Traffic into Multiple Sub-Streams
Authors: Knoop Victor L. , Jettina Wierbos Maria , van Boggelen Otto
Published: September 2021

Traffic flow might be limited by cross-traffic which has priority. A typical example of such a situation is a location where cyclists or pedestrians cross a stream of car traffic. Splitting the cross-traffic into two separate sub-streams (for instance left–right and right–left) can increase the capacity of the main stream. This is because it is no longer necessary to have a sufficiently large gap in both sub-streams simultaneously. This paper introduces a method to compute the resulting capacity of roads with cross-traffic. Without loss of generality, we introduce three transformations to simplify computations. These transformations are an important contribution of the paper, allowing us to create scalable graphs for capacity. Overall, the research shows that splitting a crossing stream into two equally large sub-streams increases the capacity of the main stream. If there is place for one vehicle in between two sub-streams, the capacity can increase up to threefold. Even larger gains are possible with more vehicles in between. This paper presents graphs which can be used to find the capacity for generic situations, and can be used for developing guidelines on intersection design.
Familial Risk and Its Interaction With Body Mass Index and Physical Activity in Anterior Cruciate Ligament Injury Among First-Degree Relatives: A Population-Based Cohort Study
Authors: Ahn Hyeong Sik , Lee Dae-Hee , Kazmi Sayada Zartasha , Kang Taeuk , Lee Young Sung , Sung Ryunsu , Cha Jaewoo , Choi Yoon Jung , Hong Gahwi , Hann Hoo Jae , Kim Hyun Jung
Published: September 2021

Background:

Genetic and behavioral risk factors have been suggested to play a role in anterior cruciate ligament (ACL) injury. However, population-based familial risk estimates are unavailable.

Purpose:

To quantify familial risk of ACL injury among first-degree relatives (FDRs) after controlling for certain behavioral risk factors. To estimate the combined effect of family history and body mass index (BMI) or physical activity on the risk of ACL injury.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Using nationwide data from the Korean National Health Insurance and National Health Screening Program databases on kinship, lifestyle habits, and anthropometrics, 5,184,603 individuals with blood-related FDRs were identified from 2002 to 2018. Familial risk of ACL injury, as represented as incidence risk ratios (IRRs) with 95% CIs, was analyzed using Cox proportional hazards models among individuals with versus without affected FDRs. Analyses were adjusted for age, sex, and behavioral risk factors. Interaction testing between familial history and BMI or physical activity was performed on an additive scale.

Results:

The risk of ACL injury was 1.79-fold higher (IRR, 1.79; 95% CI, 1.73-1.85) among individuals with versus without affected FDRs, and the incidence was 12.61 per 10,000 person-years. The IRR (95% CI) was highest with affected twins at 4.49 (3.01-6.69), followed by siblings at 2.31 (2.19-2.44), the father at 1.58 (1.49-1.68), and the mother at 1.52 (1.44-1.61). High BMI and high level of physical activity were significantly associated with the risk of ACL injury. Individuals with positive family history and either high BMI or physical activity had a 2.59- and 2.45-fold increased risk of injury as compared with the general population, respectively, and the combined risks exceeded the sum of their independent risks.

Conclusion:

Familial factors are risk factors for ACL injury with an additional contribution of 2 behavioral factors: BMI and physical activity level. A significant interaction was observed between family history of ACL injury and high BMI/level of physical activity.
The Eurocentrism of neo-Roman republicanism and the neglect of republican empire
Authors: Blachford Kevin
Published: September 2021

Republicanism is an approach within political theory that seeks to secure the values of political liberty and non-domination. Yet, in historical practice, early modern republics developed empires and secured their liberty through policies that dominated others. This contradiction presents challenges for how neo-Roman theorists understand ideals of liberty and political freedom. This article argues that the historical practices of slavery and empire developed concurrently with the normative ideals of republican liberty. Republican liberty does not arise in the absence of power but is inherently connected to the exercise of power.
Reducing Disparities in Academic Outcomes Among Youth of Color: Evidence From an Alternative Education Program
Authors: Phillippi Stephen , Thomas Casey L. , Gastanaduy Mariella , Sawyer Melissa
Published: September 2021

The differential treatment of youth of color in schools perpetuates disparities in academic outcomes. Alternative education programs may represent a constructive approach to preventing or mitigating these disparities. This study examines the outcomes of an urban alternative education program in the United States. Secondary analysis of demographic, psychosocial, and academic data from all program participants ( N = 232) during a 3-year study period was conducted. Descriptive statistics summarize demographic characteristics, and bivariate analyses examine the strength of association and interrelationships among individual variables, program retention, and educational attainment. Results show grade-level advancement, employability, and, therefore, decreased risk for justice involvement, regardless of students’ histories of lower academic performance, unemployment, behavioral health conditions, and justice system or child protective services contact. This evaluation offers a framework for replication and recommendations for future research examining alternative education programs.