bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-omics analysis to reveal the synergistic mechanism underlying the multiple ingredients of Stephania tetrandra extract on rheumatoid arthritis through the PI3K/Akt signaling pathway
Authors: Chen Jinfeng , Zhang An , Nie Anzheng , Zuo Xiaoxiao , Zhang Lei , Jiao Yuxue , Wang Lulu , Yang Yang , Liu Kun , Xue Xinli , Zhuang Yuanyuan , Meng Yansha , Yang Jing-Hua
Published: August 2024

Background:Stephania tetrandra has been used for treating rheumatic diseases for thousands of years in rural areas of China. Several studies have found that tetrandrine and fangchinoline can inactivate the PI3K/Akt signaling pathway by reducing the expression and phosphorylation of AKT. However, the mechanism underlying the therapeutic actions of S. tetrandra on RA is not well known.

Methods: In this study, we determined the molecular mechanism of the therapeutic effects of the multiple ingredients of S. tetrandra extract (STE) on collagen-induced arthritic (CIA) rats by integrating pharmacometabolomics, proteomics, and PTMomics.

Results: In the multi-omics joint analysis, first, the expression signatures of proteins, PTMs, metabolites, and STE ingredients were profiled in CIA rats PBMCs that underwent STE treatment. Bioinformatics analysis were subsequently probed that STE mainly regulated tryptophan metabolism, inflammatory response, and cell adhesion pathways in CIA rats. The interrelated pathways were further constructed, and the findings revealed that STE attenuated the inflammatory response and proliferation of PBMCs in CIA rats by mediating the key targets of the PI3K/Akt pathway, including Hint1, ACP1, FGR, HSP90@157W + dioxidation, and Prkca@220N + 845.4540 Da. The rheumatic functions of Hint1 and ACP1 were further confirmed by applying a transcriptomic data of RA patients who clinically received abatacept therapy. Furthermore, a cross-ome correlation analysis was performed and major in vivo ingredients of STE, including coclaurine-N-glucuronide, Me,coclaurine-O-glc, N-gluA-schefferine, corydamine, corypamine, tetrandrine, and fangchiniline, were found to act on these targerts to inactivate the PI3K/Akt pathway.

Conclusion: These results elucidated the molecular mechanism by which the ingredients of STE mediate the expression of the key targets in the PI3K/Akt pathway, leading to anti-rheumatic functions. The findings of this study provided new insights into the synergistic effect of STE against arthritis in rats.
Spin glasses and percolation
Authors: Münster Lambert , Weigel Martin
Published: August 2024

The description of thermodynamic phase transitions in terms of percolation transitions of suitably defined clusters has a long tradition and boasts a number of important successes, the most prominent ones being in ferromagnetic lattice models. Spin glasses and other frustrated systems are not among them as the clusters of aligned spins usually considered in this context start to percolate in the disordered phase and hence fail to indicate the onset of ordering. In this mini-review we provide an overview of the state of the art in this field, including recent advances, and outline the main open questions in the area.
Effects of multidimensional exercise management on self-efficacy, blood glucose control, and delivery outcomes in pregnant women with gestational diabetes mellitus
Authors: He Ying , Liu Xin , Yang Xiali
Published: August 2024

Objective

This study aimed to evaluate the effects of multidimensional quantitative exercise management on self-efficacy, blood glucose control, and delivery outcomes in pregnant women with gestational diabetes mellitus (GDM).

Methods

A randomized controlled trial was conducted with 150 pregnant women diagnosed with gestational diabetes mellitus (GDM). Participants were randomly assigned to either the experimental group (Exp), which received a multidimensional quantitative exercise management intervention, or the control group (Con), which received standard GDM management. Results were compared between the groups included self-efficacy scores, blood glucose levels, and delivery outcomes.

Results

Exp group of pregnant women exhibited drastically superior self-efficacy scores as well as more stable blood glucose levels during pregnancy relative to Con group (P < 0.05). Moreover, visual analogue scale (VAS) of pregnant women and Apgar scores of infants in Exp group were considerably better than those in Con group (P < 0.05). In contrast to Con group, pregnant women in Exp group had considerably better labor outcomes along neonatal complication rates (P < 0.05).

Conclusion

Multidimensional quantitative exercise management had a positive impact on pregnant women with GDM. This intervention method can improve self-efficacy levels along better blood glucose control, and enhance delivery outcomes. These findings suggested that multidimensional quantitative exercise management has potential clinical value in the management of GDM, providing an effective management strategy to improve the health conditions of both pregnant women and infants.
Evaluation of cell death-inducing activity of Monilinia spp. effectors in several plants using a modified TRV expression system
Authors: López Anselmo , van Kan Jan A. L. , Beenen Henriek G. , Dolcet-Sanjuan Ramon , Teixidó Neus , Torres Rosario , Vilanova Laura
Published: August 2024

Introduction

Brown rot is the most important fungal disease affecting stone fruit and it is mainly caused by Monilinia fructicola, M. laxa and M. fructigena. Monilinia spp. are necrotrophic plant pathogens with the ability to induce plant cell death by the secretion of different phytotoxic molecules, including proteins or metabolites that are collectively referred to as necrotrophic effectors (NEs).

Methods

We exploited the genomes of M. fructicola, M. laxa and M. fructigena to identify their common group of secreted effector proteins and tested the ability of a selected set of effectors to induce cell death in Nicotiana benthamiana, Solanum lycopersicum and Prunus spp. leaves.

Results

Fourteen candidate effector genes of M. fructicola, which displayed high expression during infection, were transiently expressed in plants by agroinfiltration using a modified Tobacco Rattle Virus (TRV)-based expression system. Some, but not all, effectors triggered leaf discoloration or cell death in N. benthamiana and S. lycopersicum, which are non-hosts for Monilinia and in Prunus spp., which are the natural hosts. The effector MFRU_030g00190 induced cell death in almost all Prunus genotypes tested, but not in the Solanaceous plants, while MFRU_014g02060, which is an ortholog to BcNep1, caused necrosis in all plant species tested.

Conclusion

This method provides opportunities for screening Prunus germplasm with Monilinia effector proteins, to serve as a tool for identifying genetic loci that confer susceptibility to brown rot disease.
Bridging agro-science and human nutrition: zinc nanoparticles and biochar as catalysts for enhanced crop productivity and biofortification
Authors: Ahmed Nazir , Deng Lifang , Narejo Mehar-un-Nisa , Baloch Iqra , Deng Lansheng , Chachar Sadaruddin , Li Yongquan , Li Juan , Bozdar Bilquees , Chachar Zaid , Hayat Faisal , Chachar Muzafaruddin , Gong Lin , Tu Panfeng
Published: August 2024

The integration of zinc nanoparticles (Zn NPs) with biochar offers a transformative approach to sustainable agriculture by enhancing plant productivity and human nutrition. This combination improves soil health, optimizes nutrient uptake, and increases resilience to environmental stressors, leading to superior crop performance. Our literature review shows that combining Zn NPs with biochar significantly boosts the crop nutrient composition, including proteins, vitamins, sugars, and secondary metabolites. This enhancement improves the plant tolerance to environmental challenges, crop quality, and shelf life. This technique addresses the global issue of Zn deficiency by biofortifying food crops with increased Zn levels, such as mung beans, lettuce, tomatoes, wheat, maize, rice, citrus, apples, and microgreens. Additionally, Zn NPs and biochar improve soil properties by enhancing water retention, cation exchange capacity (CEC), and microbial activity, making soils more fertile and productive. The porous structure of biochar facilitates the slow and sustained release of Zn, ensuring its bioavailability over extended periods and reducing the need for frequent fertilizer applications. This synergy promotes sustainable agricultural practices and reduces the environmental footprint of the traditional farming methods. However, potential ecological risks such as biomagnification, nanoparticle accumulation, and toxicity require careful consideration. Comprehensive risk assessments and management strategies are essential to ensure that agricultural benefits do not compromise the environmental or human health. Future research should focus on sustainable practices for deploying Zn NPs in agriculture, balancing food security and ecological integrity and positioning this approach as a viable solution for nutrient-efficient and sustainable agriculture.
Full-length RNA sequencing and single-nucleus sequencing deciphers programmed cell death and developmental trajectories in laticiferous canals of Decaisnea insignis fruits
Authors: Li Gen , Zhao Qian , Shi Xinwei , Li Bin , Yang Luyao , Wang Yanwen , Zhou Yafu
Published: August 2024

Introduction

Programmed cell death (PCD) is a fundamental biological process crucial for plant development. Despite recent advancements in our understanding of PCD’s molecular mechanisms, the intricate orchestration of this process within plant cells remains enigmatic. To address this knowledge gap, the present study focuses on Decaisnea insignis, a plant species renowned for its unique fruit anatomy, including laticiferous canals that secrete latex. While extensive anatomical studies have elucidated the structural features of these canals,molecular insights into their developmental regulation, particularly the involvement of PCD, are lacking.

Methods

In this study, we sequenced the single-cell transcriptomes at two developmental stage of Decaisnea insignis fruit using the technology known as 10x Genomics (S1, S2). Using sequencing technology combining full- length RNA sequencing and single-nucleus RNA sequencing (snRNA-seq) in combination with ultrastructural analyses, our study revealed a cellular map of Decaisnea insignis fruit at the single-cell level and identified different cell types.

Results

In particular, we identified a possible PCD-mediated cluster of Decaisnea insignis fruit lactiferous canals in epidermal cells and clarified the expression patterns of DiRD21A (a hydrolase) and DiLSD1 (a transcription factor), which may be closely related to the development of laticiferous canals in Decaisnea insignis fruits.

Discussion

By integrating high-resolution gene expression profiling with visual insights into cellular transformations, we sought to more precisely characterize the regulatory role of PCD during the developmental formation of lactiferous canals in Decaisnea insignis fruit.
An indicator of the view of time passing: the development and validation of the metacognitive knowledge of time passing scale (MKTPS) in Chinese college students
Authors: Yu Xide , Lu Cheng , Ma Yaju , Huang Li , Wu Chenyang
Published: August 2024

How we view the passage of past time determines how we face time itself as well as our futures, which has a strong impact particularly during the highly creative and malleable college years. Chinese culture cherishes time deeply, and for centuries there has been a tradition of “educating children and youth to inspect the passage of time.” However, in today’s age of information and intelligence, time has shown a trend toward fragmentation. How do contemporary Chinese college students view the passage of time, and what structures or content does it contain? The answer to this question remains uncertain, necessitating further exploration. Following Flavell’s theory of metacognitive knowledge (MK), we adopted a semi-structured interview method and used the results to first outline the basic structure of Chinese college students’ view of time passing, identifying four major aspects: priming aftereffect, life touching, positive promotion, and negative inhibition. Then, using the initial four-dimensional structure as a starting point, we developed the Metacognitive Knowledge of Time Passing Scale (MKTPS), and carried out exploratory factor analysis and confirmatory factor analysis to test its fit. The results showed that the four-factor scale and its 22 items had a good fit to the data. Third, the reliability and validity of the self-developed scale were tested. The results show that the internal consistency, split-half, and retest reliability of the MKTPS are good (all rs > 0.60). The construct validity of the MKTPS is also good (rbetween subscales is 0.33–0.60, rbetween subscales and total scale is 0.64–0.87), the convergent validity with Zimbardo’s negative past time perspective is high (r = 0.37), and the discriminant validity with Zimbardo’s future time perspective is significant (r = 0.18). Regarding criterion correlation validity, the total scores of the MKTPS have a significantly higher positive correlation with those of the time management disposition (TMD) scale (r = 0.45). Future points for studying the view of time passing in adults of all ages and across cultures field and shortcomings of the current study are also discussed.
The effects of conscious movement investment on inhibiting a simple response
Authors: You Yihong , Weng Wan-Chun , Suprianto Gita Benefita , van der Kamp John
Published: August 2024

The relationship between a performer’s conscious involvement or investment in movement control and monitoring and the ability to inhibit the movement is still unclear. We conducted three experiments to investigate whether a higher inclination for conscious movement investment benefits the inhibition of a simple keypress response. In all experiments, the inclination for conscious movement investment was measured with the Movement-Specific Reinvestment Scale. In Experiment 1, participants performed the go/no-go task and conscious investment was manipulated by directing conscious attention either to the finger movement (i.e., internal focus) or to the resulting motion of the key (i.e., external focus). The results showed that neither the participants’ inclination for conscious movement investment, nor the direction of conscious attention affected inhibition performance. In Experiment 2, participants performed the stop-signal task, which is more attention demanding than the go/no-go task. The results showed that participants with a high or low inclination for conscious movement investment did not differ in inhibition performance. In Experiment 3 an ego-depletion procedure was included that limits resources for conscious movement investment. Before and after this ego-depletion procedure, participants performed the stop-signal task. The results showed that participants with a high inclination for conscious movement investment slowed down inhibition when they felt mentally depleted, while no slowing down of inhibition was found among participants who felt less depleted and/or had a low inclination for conscious movement investment. Together, the study provides evidence that increased conscious movement investment is beneficial for movement inhibition. Yet, these effects only emerge against the dynamic background of interacting individual (e.g., inclination for conscious movement investment, available attentional resources) and task constraints (e.g., task difficulty).
Impact of media dependence: how emotional interactions between users and chat robots affect human socialization?
Authors: Yuan Ziying , Cheng Xiaoliang , Duan Yujing
Published: August 2024

In the era of intelligent media, human users and chatbots have established a deep dependency relationship through communication, making media dependence a behavioral foundation that widely permeates human social practice. This article investigates how media dependence affects human social interaction during emotional interactions between human users and chatbots. Based on the theory of media dependence, the existing mature scales of media dependence and interpersonal communication were adapted, and 496 Replika user questionnaires were collected. After screening the validity of the questionnaires, 428 valid questionnaires were obtained. Descriptive statistical analysis, correlation analysis, multiple linear regression analysis, and mediation effect testing were used to analyze the impact of media dependence on human–computer emotional interaction. Results indicate a significant positive correlation between human–chatbot emotional interaction and human user social interaction. Media dependence significantly positively regulates emotional interactions between humans and chatbots. In addition, the social interactions of human users are partially influenced by factors such as user nature, age, education, and income.
Basic human values and the adoption of cryptocurrency
Authors: Stanciu Adrian , Partsch Melanie , Lechner Clemens M.
Published: August 2024

Cryptocurrency is an attempt to create an alternative to centralized financial systems using blockchain technology. However, our understanding of the psychological mechanisms that drive cryptocurrency adoption is limited. This study examines the role of basic human values in three stages of cryptocurrency adoption–awareness, intention to buy, and ownership–using the Theory of Planned Behavior (TPB). Logistic regression analysis was conducted on a quota sample of 714 German adults, and the results showed that openness-to-change values increased the likelihood of cryptocurrency awareness, while self-enhancement values increased the likelihood of intention to buy and ownership. These findings were consistent even after controlling for demographic characteristics, attitudinal beliefs, and perceived behavioral control, which are important factors in the TPB. The results suggest that basic human values may influence an individual’s decision to adopt cryptocurrency, but the transition from awareness to ownership may be influenced by socio-economic opportunities available to interested individuals.
Personality traits in musicians with different types of music performance anxiety
Authors: Spahn Claudia , Krampe-Heni Franziska , Hohagen Jesper , Immerz Anna , Nusseck Manfred
Published: August 2024

Introduction

This study investigated the relationship between personality traits and MPA in the course of a specific performance.

Methods

For this purpose, symptoms of MPA, functional coping with MPA and performance-related self-efficacy of a sample of 393 musicians including 23% professional, 49% non-professional orchestra musicians and 28% singers in amateur choirs were categorized and then used to analyze differences in the personality traits. The questionnaires used were the NEO-FFI and the PQM.

Results

The results showed that professional orchestra musicians had significantly higher openness and conscientiousness than non-professional orchestra musicians and amateur choir singers. Musicians who had few symptoms of MPA, positive coping with MPA and high self-efficacy across a specific performance (Type 1) have low neuroticism in their personality traits. Regarding MPA, the personality traits were correlated with all MPA scales after the performance but less with MPA scales before and during the performance.

Discussion

Results could indicate that personality traits play a particularly important role in the processing of performance experiences after the performance and suggest focusing on the situation after the performance in particular with professional orchestra musicians.
Research on the influence of body image on college students’ weight-loss intention: chained intermediary analysis of self-efficacy and self-esteem
Authors: Yiyi Ouyang , Xue Xiong , Jiong Luo , Yanhui Zhang
Published: August 2024

Purpose

This paper aims to explore the relationship between body image, self-efficacy, self-esteem, and weight-loss intention among college students, offering insights to promote healthy and confident lifestyle habits.

Methods

Undergraduate students from western China were selected using a stratified random sampling method. Data were analyzed using SPSS 19.0 and AMOS 21.0 statistical software.

Results

(1) Body image showed a significantly positive correlation with self-efficacy and self-esteem but a negative correlation with weight-loss intention. Self-efficacy exhibited a significantly positive correlation with self-esteem and a negative correlation with weight-loss intention, while self-esteem was significantly negatively correlated with weight-loss intention. (2) Body image directly impacted weight-loss intention [Effect Size (ES) = −0.120]. Self-efficacy (ES = −0.069) and self-esteem (ES = −0.119) played significant mediating roles between body image and weight-loss intention, respectively. (3) The chained intermediary role of self-efficacy and self-esteem also reached significance (ES = −0.038).

Conclusion

Body image conducts effect on the degree of weight-loss intention among college students through direct ways or indirect ways such as the intermediary role of self-efficacy and self-esteem, and also the chained intermediary role of self-efficacy and self-esteem. In addition, self-esteem is another key factors affecting college students’ weight-loss intention.
Pulmonary embolism incidence among patient admitted under psychiatry department: a case-control study
Authors: Zhang Wanling , Paudel Dhirendra , Shi Rui , Yang Junwei , Liu Jingwen , Jia Yanbin
Published: August 2024

Background

Pulmonary embolism (PE) is a serious and potentially life-threatening condition that requires prompt diagnosis and treatment. Identifying risk factors and diagnostic markers can aid in the early detection and management of this condition.

Methods

This case-control study examined 10,077 patients admitted to Shenzhen Kangning Hospital’s psychiatry facility in 2020. Among these, 65 patients were diagnosed with PE, including 50 new cases. After survival sampling for controls and age-and-gender matching, the study included 41 new PE cases and 41 age-and-gender-matched controls. Data on demographics, comorbidities, and medication use were extracted from electronic records. Conditional logistic regression analyses were performed to determine the association between each predictor and PE risk. Additionally, the sensitivity and specificity of the d-dimer diagnostic tool were assessed.

Results

In univariable conditional logistic regression, active alcoholism was associated with a higher PE risk (OR=3.675, 95% CI 1.02–13.14, P=0.046). A history of physical restraint (OR=4.33, 95% CI 1.24–15.21, P=0.022) and chemical restraint (OR 4.67, 95% CI 1.34–16.24, p=0.015) also increased PE risk, as did benzodiazepine use (OR=3.33, 95% CI 1.34–8.30, P=0.010). Conversely, psychotropic medication before admission was associated with a lower risk of PE (OR=0.07, 95% CI 0.01–0.59, P=0.013). Stepwise multivariable forward conditional regression identified two subsets of psychiatric patients at higher risk of PE: new psychiatric cases without medication at admission who were chemically restrained, and cases without medication at admission who were started on antipsychotics and benzodiazepines. The d-dimer diagnostic tool, with an optimal threshold of 570 ng/ml determined by the Youden index (J statistic of 0.6098), showed a sensitivity of 73.17% and specificity of 87.80% for detecting PE, with an AUC of 0.833 (95% CI: 0.735–0.906).

Conclusion

Our findings suggest that a history of restraint, alcoholism, and the use of antipsychotics and benzodiazepines are important predictors of PE in psychiatric inpatients. Conversely, psychotropic medications at admission may be linked to a lower PE risk. The d-dimer diagnostic tool shows good value for screening PE in psychiatric inpatients. These predictors and diagnostic markers could help clinicians identify high-risk patients and implement appropriate prevention strategies.
Prevalence of typhoid fever and its associated factors among febrile patients visiting Arerti Primary Hospital, Amhara Region, north east Ethiopia
Authors: Muche Genet , Tesfaw Asmamaw , Bayou Fekade Demeke
Published: August 2024

Background

Typhoid fever is one of the major public health concerns in developing countries, including Ethiopia. Understanding the burden and factors contributing to the transmission and development of the disease is crucial to applying appropriate preventive and therapeutic interventions.

Objective

To assess the prevalence of typhoid fever and its associated factors among febrile patients visiting Arerti Primary Hospital from 1 March to 30 May 2022.

Methods

A facility-based cross-sectional study was employed among 326 febrile patients visiting Arerti Primary Hospital for health services. The data were collected using laboratory procedures (widal test) and a structured interviewer-administered questionnaire. The data were entered using Epi Data version 3.1 and analyzed by SPSS version 25. Logistic regression was used to determine associations between variables. P-value < 0.05 and adjusted odds ratio with 95% confidence interval were used to measure the presence and strength of associations.

Results

In this study, of the total 317 cases that participated, the majority (64.4%) of them were males with age ranges from 13 to 63 years. The overall prevalence of positive antigen tests for typhoid infection was 30.0% (95% CI: 25.0%−35.3%). About 66.9% of the study participants had good knowledge, 75.7% had favorable perception, and 42.3% had good infection prevention practice. Being unemployed [AOR = 7.57, 95% CI (1.98, 28.93)], being a farmer [AOR = 2.73, 95% CI (1.01, 7.41)], and having a body mass index (BMI) below 18.5 kg/m2 [AOR = 5.12, 95%CI (2.45, 10.68)] were significantly associated with typhoid fever infection.

Conclusion

The prevalence of typhoid fever among febrile patients was high. Typhoid fever infection was significantly associated with occupational status (being unemployed and being a farmer) and lower BMI. The level of knowledge, perception, and practice of typhoid fever infection prevention were found inadequate. Therefore, behavioral change interventions are needed at the community level.
Pandemic preparedness: why humanities and social sciences matter
Authors: Frampton Sally , Orievulu Kingsley , Matthews Philippa C. , Giubilini Alberto , Hordern Joshua , Burns Lizzie , Elias Sean , Friederich Ethan , Majozi Nomathamsanqa , Martin Sam , Stevenson Austin , Vanderslott Samantha , Seeley Janet
Published: August 2024

Whilst many lessons were learned from the COVID-19 pandemic, ongoing reflection is needed to develop and maintain preparedness for future outbreaks. Within the field of infectious disease and public health there remain silos and hierarchies in interdisciplinary work, with the risk that humanities and social sciences remain on the epistemological peripheries. However, these disciplines offer insights, expertise and tools that contribute to understanding responses to disease and uptake of interventions for prevention and treatment. In this Perspective, using examples from our own cross-disciplinary research and engagement programme on vaccine hesitancy in South Africa and the United Kingdom (UK), we propose closer integration of expertise, research and methods from humanities and social sciences into pandemic preparedness.
Occurrence, multidrug resistance and potential risk factors for Staphylococcus aureus infection at worker-animal and working equipment interfaces: a systematic review and meta-analysis of the Ethiopian literature
Authors: Mengistu Bemrew Admassu , Getnet Kalkidan , Mebratu Atsede Solomon , Fenta Melkie Dagnaw
Published: August 2024

Background

Staphylococcus aureus (S. aureus) infecting animals and humans via close contact, handling, or consuming contaminated products is a growing public health concern. In Ethiopia, it is important to examine the overall prevalence of S. aureus, patterns of multidrug resistance, and potential risks in human-animal interface settings. Thus, this review was conducted to estimate the pooled prevalence of S. aureus, its multidrug resistance, and potential risk factors for worker-animal-working equipment interactions.

Methods

This systematic review and meta-analysis were carried out by the PRISMA guidelines. The research articles were searched from PubMed, HINARI, Web of Sciences, and Google Scholar databases.

Results

This meta-analysis included 13 independent articles and 52 dependent studies. In total, 5,329 humans, 5,475 animals, and 5,119 samples of working equipment were analyzed. The pooled prevalence of S. aureus at the interfaces between humans, animals, and working equipment was 22%, there was a high level of heterogeneity (I2 = 94%: p < 0.01). The overall pooled prevalence of S. aureus in dairy farm sources was 23% (95% CI, 17–30%) compared to 18% in abattoirs. The pooled prevalence of S. aureus was estimated to be 25% for human sources, 23% for animal sources, and 19% for working equipment. The total multidrug resistance (MDR) rate was 27%. The present study illustrates that a predominant antimicrobials comprising ampicillin, penicillin, chloramphenicol, tetracycline, and ciprofloxacin, accounts for the development of resistance in S. aureus strains, with a prevalence of 72%. According to the qualitative assessment of potential risk factors, animal age, worker education, lactation stage, and hand washing by milkers influenced the circulation of S. aureus at animal-worker and working equipment interfaces.

Conclusion

The pooled prevalence of S. aureus at the interface of human,-and animal-working equipment was quantified at 22%. S. aureus was found in humans, animals, and equipment at nearly the same rate. The results of this study demonstrate that S. aureus is hazardous and circulates among animals, workers, and equipment: farmers, animal owners, employees, and the public need to be educated about S. aureus. Moreover, animals and work equipment should be included in the control and prevention of S. aureus infection.
Sufficient sleep and its contributing factors among high school students during the COVID-19 pandemic: results from adolescent behaviors and experiences survey
Authors: Chen Zhengyang , Li Ruili , Liu Yuexi , Lian Qiguo
Published: August 2024

Background

The COVID-19 pandemic has caused profound changes in adolescent lives, including school closures, social isolation, family economic hardship, and sleep schedule. We aimed to assess the risk and protective factors of sufficient sleep among adolescents during COVID-19.

Methods

We conducted secondary analysis based on the cross-sectional school-based Adolescent Behaviors and Experiences Survey in 2021 (n = 7,705). The ABES collected information on health-related experiences and behaviors during COVID-19. The outcome was sufficient sleep (eight and more hours of sleep on the average school night). The contributing factors included demographic, mental health, and adverse experiences indicators. We estimated the prevalence of sufficient sleep within each factor, and examined their associations using Chi-square test. We further investigated the contributing factors of sufficient sleep using multivariate logistic regression and reported the adjusted odds ratios (AORs) and 95% confidence intervals (CIs).

Results

During January–June 2021, 23.5% of the U.S. high school students reported getting sufficient sleep. The multivariate logistic regression indicated that younger age (AOR, 2.04; 95%CI, 1.59–2.62), heterosexual identity (AOR, 1.61; 95%CI, 1.19–2.18), no poor mental health during the past 30 days (AOR, 1.37; 95%CI, 1.03–1.82), no persistent feelings of sadness or hopelessness (AOR, 1.34; 95%CI, 1.09–1.66), no food and nutrition insecurity (AOR, 1.47; 95%CI, 1.17–1.85), never been abused by a parent emotionally (AOR, 1.38; 95%CI, 1.16–1.64), and no schoolwork difficulty (AOR, 1.24; 95%CI, 1.01–1.51) were associated with sufficient sleep.

Conclusion

We estimated the national prevalence of adolescent sufficient sleep during the COVID-19 pandemic and found that younger students, sexual heterosexual students, and students without certain mental health conditions or adverse experiences are at higher likelihood of sufficient sleep. These findings can help develop effective interventions on sleep duration in the response to a possible future pandemic caused by Disease X.
Dengue virus and the 2024 Paris Olympics
Authors: Zandi Milad , Alizadeh Ismaeil , Mousavi Fatemeh Sadat , Faraji Maryam
Published: August 2024

The 2024 Paris Olympics and Paralympics face concerns over dengue virus transmission, despite Paris’s lower mosquito activity. Preventive measures include eliminating breeding sites, insecticide spraying, and public awareness. Health systems will monitor and respond to cases. Large gatherings like the Olympics can amplify disease spread, as seen with Zika in Rio 2016. Recent reports confirm dengue presence in Europe, highlighting global risks. While Paris’s overall dengue risk is low, even a few cases could impact global health. Collaboration among health authorities, researchers, and event organizers is crucial to ensure participant and public safety during the games.
Innovative approaches for managing patients with chronic vestibular disorders: follow-up indicators and predictive markers for studying the vestibular error signal
Authors: Xavier Frédéric , Chouin Emmanuelle , Tighilet Brahim , Chabbert Christian , Besnard Stéphane
Published: August 2024

Introduction

Despite significant advancements in understanding the biochemical, anatomical, and functional impacts of vestibular lesions, developing standardized and effective rehabilitation strategies for patients unresponsive to conventional therapies remains a challenge. Chronic vestibular disorders, characterized by permanent or recurrent imbalances and blurred vision or oscillopsia, present significant complexity in non-pharmacological management. The complex interaction between peripheral vestibular damage and its impact on the central nervous system (CNS) raises questions about neuroplasticity and vestibular compensation capacity. Although fundamental research has examined the consequences of lesions on the vestibular system, the effect of a chronic peripheral vestibular error signal (VES) on the CNS remains underexplored. The VES refers to the discrepancy between sensory expectations and perceptions of the vestibular system has been clarified through recent engineering studies. This deeper understanding of VES is crucial not only for vestibular physiology and pathology but also for designing effective measures and methods of vestibular rehabilitation, shedding light on the importance of compensation mechanisms and sensory integration.

Methods

This retrospective study, targeting patients with chronic unilateral peripheral vestibulopathy unresponsive to standard treatments, sought to exclude any interference from pre-existing conditions. Participants were evaluated before and after a integrative vestibular exploratory and rehabilitation program through questionnaires, posturographic tests, and videonystagmography.

Results

The results indicate significant improvements in postural stability and quality of life, demonstrating positive modulation of the CNS and an improvement of vestibular compensation.

Discussion

Successful vestibular rehabilitation likely requires a multifaceted approach that incorporates the latest insights into neuroplasticity and sensory integration, tailored to the specific needs and clinical progression of each patient. Focusing on compensating for the VES and enhancing sensory-perceptual-motor integration, this approach aims not just to tailor interventions but also to reinforce coherence among the vestibular, visual, and neurological systems, thereby improving the quality of life for individuals with chronic vestibular disorders.
Resting muscle tension and trigger points in elite junior short-track athletes and healthy non-athletes: a cross-sectional examination
Authors: Konieczny Mariusz , Matuska Jakub , Pakosz Paweł , Domaszewski Przemysław , Skulska Marta , Herrero Pablo , Skorupska Elżbieta
Published: August 2024

Introduction

Short-track speed skating (short track) is an Olympic sport characterized by a specific body position and counterclockwise movement on the track. Based on previous studies, we hypothesized that athlete body positions employed in this sport could lead to asymmetric overuse disorders of the left lower limb muscles. An increased number of latent trigger points (LTrPs) was confirmed in individual muscles of the overloaded left limb of short-track athletes. This study aimed to compare the number of LTrPs and the level of resting muscle tone between elite junior short-track athletes and healthy non-athletes.

Methods

The experimental (EXP) group comprised 15 elite short-track junior athletes from the Polish national team and the control (CON) group comprised 15 healthy young volunteers. In both groups, the left leg was tested for (i) the presence of LTrPs and (ii) resting muscle tone (RMT), assessed using surface electromyography in six muscles.

Results

The EXP group showed a higher number of LTrPs in the left lower limb, compared with the CON group. The muscle that was most significantly affected in the athletes was the vastus lateralis obliquus [χ2 (1, N = 30), p < 0.001, V Cramer = 0.71]. This muscle also differed significantly between the groups in terms of the RMT (p = 0.033, Cohen's d = 0.87).

Conclusions

Elite short-track junior athletes presented with increased RMT and an increased number of LTrPs in the vastus lateralis oblique muscle, compared with healthy non-athletes.
Effect of altered production and storage of dopamine on development and behavior in C. elegans
Authors: Lee Irene , Knickerbocker Ava C. , Depew Charlotte R. , Martin Elizabeth L. , Dicent Jocelyn , Miller Gary W. , Bucher Meghan L.
Published: August 2024

Introduction

The nematode, Caenorhabditis elegans (C. elegans), is an advantageous model for studying developmental toxicology due to its well-defined developmental stages and homology to humans. It has been established that across species, dopaminergic neurons are highly vulnerable to neurotoxicant exposure, resulting in developmental neuronal dysfunction and age-induced degeneration. C. elegans, with genetic perturbations in dopamine system proteins, can provide insight into the mechanisms of dopaminergic neurotoxicants. In this study, we present a comprehensive analysis on the effect of gene mutations in dopamine-related proteins on body size, development, and behavior in C. elegans.

Methods

We studied C. elegans that lack the ability to sequester dopamine (OK411) and that overproduce dopamine (UA57) and a novel strain (MBIA) generated by the genetic crossing of OK411 and UA57, which both lack the ability to sequester dopamine into vesicles and, additionally, endogenously overproduce dopamine. The MBIA strain was generated to address the hypothesis that an endogenous increase in the production of dopamine can rescue deficits caused by a lack of vesicular dopamine sequestration. These strains were analyzed for body size, developmental stage, reproduction, egg laying, motor behaviors, and neuronal health utilizing multiple methods.

Results

Our results further implicate proper dopamine synthesis and sequestration in the regulation of C. elegans body size, development through larval stages into gravid adulthood, and motor functioning. Furthermore, our analyses demonstrate that body size in terms of length is distinct from the developmental stage as fully developed gravid adult C. elegans with disruptions in the dopamine system have decreased body lengths. Thus, body size should not be used as a proxy for the developmental stage when designing experiments.

Discussion

Our results provide additional evidence that the dopamine system impacts the development, growth, and reproduction in C. elegans. Furthermore, our data suggest that endogenously increasing the production of dopamine mitigates deficits in C. elegans lacking the ability to package dopamine into synaptic vesicles. The novel strain, MBIA, and novel analyses of development and reproduction presented here can be utilized in developmental neurotoxicity experiments.
The heart of plastic: utilizing the Drosophila model to investigate the effects of micro/nanoplastics on heart function
Authors: Hohman Alyssa M. , Sorensen Rachel M. , Jovanovic Boris , McNeill Elizabeth M.
Published: August 2024

Microplastics (MPs) and nanoplastics (NPs) have increasingly been found in the environment. Until recently, most MPs/NPs toxicological research has been done in aquatic systems resulting in a gap in knowledge regarding terrestrial systems. Plastics have been shown to enter the circulatory system of humans, and can accumulate within organs, little is known about the effect this has on health. Heart disease is the leading cause of death globally, so it’s critical to understand the possible impacts MPs/NPs have on the heart. The Drosophila model has been growing in popularity within the toxicology field, it allows for affordable and rapid research on the impacts of a variety of toxins, including plastics. Some research has examined toxicological effects of plastics on the fly, evaluating the effects on mortality, fecundity, development, and locomotion. However, no one has studied the effects on the Drosophila heart. We utilize the Drosophila model to identify the potential effects of oral exposure to polystyrene MPs (1 µm in diameter) and NPs (0.05 µm in diameter) particles on heart function. Flies were exposed to 1.4 × 1011 particles/d/kg of larvae for MPs and 1.2 × 1018 particles/d/kg of larvae for NPs from egg to pupal eclosion. Heart function was then analyzed utilizing semi-intact dissections and Semi-automatic Optic Heartbeat Analysis software (SOHA). Following exposure to MPs and NPs we see sexually dimorphic changes to heart size and function. This study highlights the importance of additional Drosophila MPs/NPs research to identify the molecular mechanisms behind these changes.
Neutrosophic Analysis of Experimental Data Using Neutrosophic Graeco-Latin Square Design
Authors: Kumar Pranesh , Moazzamigodarzi Mahdieh , Rahimi Mohamadtaghi
Published: August 2024

Experimental designs are commonly used to produce valid, defensible, and supportable conclusions. Among commonly used block designs, the class of Latin square designs is used to study factors or treatment levels expressed as Latin letters and applying two blocking factors in rows and columns to simultaneously control two sources of nuisance variability. Another block design in which the error can be controlled by blocking three nuisance factors is obtained by simply using two superimposed Latin square designs, with one using the Latin letters and the other using the Greek letters. Such a design is termed as a Graeco-Latin square (GLS) design. While observing or measuring data in field or lab experiments, it is often noted to have vague, incomplete, and imprecise data for whatsoever reasons. In this regard, researchers have proposed various emerging approaches, which are based on fuzzy, intuitionistic fuzzy, and neutrosophic logic, and provide deeper understanding, analysis, and interpretations of the data. In this paper, we provide a brief review of the history of GLS designs and propose a neutrosophic Graeco-Latin square design, its model, and the analysis. To illustrate this, we have considered an experimental study which analyzes the effects of different formulations of a rocket propellant, which are used in aircrew escape systems, on the observed burning rate.
On Some Forgotten Formulas of L. de Broglie and the Nature of Thermal Time
Authors: Chiatti Leonardo
Published: August 2024

From 1948 until around 1965, Louis de Broglie, awarded the Nobel Prize for Physics in 1929 for his fundamental contributions to quantum theory, pursued a systematic study of the formal analogies between wave mechanics and the thermomechanics of Boltzmann and Helmholtz. As part of this line of research, he produced several interesting observations, which were, however, published only in French, and, therefore, had a very limited diffusion. Here, we reconsider, in particular, a result of his relating to the analogy between the internal clock (de Broglie phase) of a free particle and a cyclic isothermal process in a thermomechanical system. We show that the fundamental equivalence obtained by him can be derived under more convenient hypotheses than the original ones, essentially tied to the quantization of the action exchanged by the particle with a suitable thermostat. In this emended formulation, the relations proposed by de Broglie describe the emergence of the particle proper time from a thermal background. They also suggest a specific physical meaning of the Wick rotation, often used in quantum mechanical calculations, and the thermal time that appears in it.
Percolation Transitions in Edge-Coupled Interdependent Networks with Reinforced Inter-Layer Links
Authors: Zhang Junjie , Liu Caixia , Liu Shuxin , Wang Kai , Zang Weifei
Published: August 2024

Prior research on cascading failures within interdependent networks has predominantly emphasized the coupling of nodes. Nevertheless, in practical networks, interactions often exist not just through the nodes themselves but also via the connections (edges) linking them, a configuration referred to as edge-coupled interdependent networks. Past research has shown that introducing a certain percentage of reinforced nodes or connecting edges can prevent catastrophic network collapses. However, the effect of reinforced inter-layer links in edge-coupled interdependent networks has yet to be addressed. Here, we develop a theoretical framework for studying percolation models in edge-coupled interdependent networks by introducing a proportion of reinforced inter-layer links and deriving detailed expressions for the giant and finite components and the percolation phase transition threshold. We find that there exists a required minimum proportion of the reinforced inter-layer links to prevent abrupt network collapse, which serves as a boundary to distinguish different phase transition types of a network. We provide both analytical and numerical solutions for random and scale-free networks, demonstrating that the proposed method exhibits superior reinforcement efficiency compared to intra-layer link reinforcement strategies. Theoretical analysis, simulation results, and real network systems validate our model and indicate that introducing a specific proportion of reinforced inter-layer links can prevent abrupt system failure and enhance network robustness in edge-coupled interdependent networks.
A History of Channel Coding in Aeronautical Mobile Telemetry and Deep-Space Telemetry
Authors: Rice Michael
Published: August 2024

This paper presents a history of the development of channel codes in deep-space telemetry and aeronautical mobile telemetry. The history emphasizes “firsts” and other remarkable achievements. Because coding was used first in deep-space telemetry, the history begins with the codes used for Mariner and Pioneer. History continues with the international standard for concatenated coding developed for the Voyager program and the remarkable role channel coding played in rescuing the nearly-doomed Galileo mission. The history culminates with the adoption of turbo codes and LDPC codes and the programs that relied on them. The history of coding in aeronautical mobile telemetry is characterized by a number of “near misses” as channel codes were explored, sometimes tested, and rarely adopted. Aeronautical mobile telemetry is characterized by bandwidth constraints that make use of low-rate codes and their accompanying bandwidth expansion, an unattractive option. The emergence of a family of high-rate LDPC codes coupled with a bandwidth-efficient modulation has nudged the aeronautical mobile telemetry community to adopt the codes in their standards.