bluuebunny/crossref_metadata_2025 huggingface dataset:
Accent modification for speech recognition of non-native speakers using neural style transfer
Authors: Radzikowski Kacper , Wang Le , Yoshie Osamu , Nowak Robert
Published: February 2021

Nowadays automatic speech recognition (ASR) systems can achieve higher and higher accuracy rates depending on the methodology applied and datasets used. The rate decreases significantly when the ASR system is being used with a non-native speaker of the language to be recognized. The main reason for this is specific pronunciation and accent features related to the mother tongue of that speaker, which influence the pronunciation. At the same time, an extremely limited volume of labeled non-native speech datasets makes it difficult to train, from the ground up, sufficiently accurate ASR systems for non-native speakers.In this research, we address the problem and its influence on the accuracy of ASR systems, using the style transfer methodology. We designed a pipeline for modifying the speech of a non-native speaker so that it more closely resembles the native speech. This paper covers experiments for accent modification using different setups and different approaches, including neural style transfer and autoencoder. The experiments were conducted on English language pronounced by Japanese speakers (UME-ERJdataset). The results show that there is a significant relative improvement in terms of the speech recognition accuracy. Our methodology reduces the necessity of training new algorithms for non-native speech (thus overcoming the obstacle related to the data scarcity) and can be used as a wrapper for any existing ASR system. The modification can be performed in real time, before a sample is passed into the speech recognition system itself.
On semidifferentiable interval-valued programming problems
Authors: Lai Kin Keung , Shahi Avanish , Mishra Shashi Kant
Published: February 2021

In this paper, we consider the semidifferentiable case of an interval-valued minimization problem and establish sufficient optimality conditions and Wolfe type as well as Mond–Weir type duality theorems under semilocalE-preinvex functions. Furthermore, we present saddle-point optimality criteria to relate an optimal solution of the semidifferentiable interval-valued programming problem and a saddle point of the Lagrangian function.
Some Padé approximations and inequalities for the complete elliptic integrals of the first kind
Authors: Mahmoud Mansour , Anis Mona
Published: February 2021

In this paper, we present Padé approximations of some functions involving complete elliptic integrals of the first kind$K(x)$K(x), and motivated by these approximations we also present the following double inequality:$$ \frac{1-x^{2}}{1-x^{2}+\frac{x^{4}}{62}}< \frac{2 e^{\frac{2}{\pi }K(x)-1}}{ (1+\frac{1}{\sqrt{1-x^{2}}} )}< \frac{1-\frac{96}{100}x^{2}}{1-\frac{96}{100}x^{2}+\frac{x^{4}}{64}},\quad x\in ( 0,1 ). $$1−x21−x2+x462<2e2πK(x)−1(1+11−x2)<1−96100x21−96100x2+x464,x∈(0,1).Our results have superiority over some new recent results.
On a doubly degenerate parabolic equation with a nonlinear damping term
Authors: Xu Wenbin
Published: February 2021

Consider a double degenerate parabolic equation arising from the electrorheological fluids theory and many other diffusion problems. Let $v_{\varepsilon }$

v
ε

be the viscous solution of the equation. By showing that $|\nabla v_{\varepsilon }|\in L^{\infty }(0,T; L_{\mathrm{loc}}^{p(x)}(\Omega ))$
|
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∞

(
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,
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;

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)

(
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)
and $\nabla v_{\varepsilon }\rightarrow \nabla v$
∇

v
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→
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almost everywhere, the existence of weak solutions is proved by the viscous solution method. By imposing some restriction on the nonlinear damping terms, the stability of weak solutions is established. The innovation lies in that the homogeneous boundary value condition is substituted by the condition $a(x)| _{x\in \partial \Omega }=0$
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x
)

|

x
∈
∂
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=
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, where $a(x)$
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(
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is the diffusion coefficient. The difficulties come from the nonlinearity of $\vert {\nabla v} \vert ^{p(x)-2}$
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as well as the nonlinearity of $|v|^{\alpha (x)}$

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.
Existence of an approximate solution for a class of fractional multi-point boundary value problems with the derivative term
Authors: Sang Yanbin , He Luxuan
Published: February 2021

In this paper, we consider a class of fractional boundary value problems with the derivative term and nonlinear operator term. By establishing new mixed monotone fixed point theorems, we prove these problems to have a unique solution, and we construct the corresponding iterative sequences to approximate the unique solution.
Correction to: Analysis of dengue model with fractal-fractional Caputo–Fabrizio operator
Authors: Fatmawati  , Khan Muhammad Altaf , Alfiniyah Cicik , Alzahrani Ebraheem
Published: February 2021

A Correction to this paper has been published: 10.1186/s13662-020-03199-3
The dynamics of COVID-19 in the UAE based on fractional derivative modeling using Riesz wavelets simulation
Authors: Mohammad Mutaz , Trounev Alexander , Cattani Carlo
Published: February 2021

The well-known novel virus (COVID-19) is a new strain of coronavirus family, declared by the World Health Organization (WHO) as a dangerous epidemic. More than 3.5 million positive cases and 250 thousand deaths (up to May 5, 2020) caused by COVID-19 and has affected more than 280 countries over the world. Therefore studying the prediction of this virus spreading in further attracts a major public attention. In the Arab Emirates (UAE), up to the same date, there are 14,730 positive cases and 137 deaths according to national authorities. In this work, we study a dynamical model based on the fractional derivatives of nonlinear equations that describe the outbreak of COVID-19 according to the available infection data announced and approved by the national committee in the press. We simulate the available total cases reported based on Riesz wavelets generated by some refinable functions, namely the smoothed pseudosplines of types I and II with high vanishing moments. Based on these data, we also consider the formulation of the pandemic model using the Caputo fractional derivative. Then we numerically solve the nonlinear system that describes the dynamics of COVID-19 with given resources based on the collocation Riesz wavelet system constructed. We present graphical illustrations of the numerical solutions with parameters of the model handled under different situations. We anticipate that these results will contribute to the ongoing research to reduce the spreading of the virus and infection cases.
A prospective cohort study evaluating screening and assessment of six modifiable risk factors in HPB cancer patients and compliance to recommended prehabilitation interventions
Authors: van Wijk Laura , van der Snee Lizzel , Buis Carlijn I. , Hentzen Judith E. K. R. , Haveman Marjolein E. , Klaase Joost M.
Published: February 2021

Introduction

Despite improvements in perioperative care, major abdominal surgery continues to be associated with significant perioperative morbidity. Accurate preoperative risk stratification and optimisation (prehabilitation) are necessary to reduce perioperative morbidity. This study evaluated the screening and assessment of modifiable risk factors amendable for prehabilitation interventions and measured the patient compliance rate with recommended interventions.

Method

Between May 2019 and January 2020, patients referred to our hospital for HPB surgery were screened and assessed on six modifiable preoperative risk factors. The risk factors and screening tools used, with cutoff values, included (i) low physical fitness (a 6-min walk test < 82% of patient’s calculated norm and/or patient’s activity level not meeting the global recommendations on physical activity for health). Patients who were unfit based on the screening were assessed with a cardiopulmonary exercise test (anaerobic threshold ≤ 11 mL/kg/min); (ii) malnutrition (patient-generated subjective global assessment ≥ 4); (iii) iron-deficiency anaemia (haemoglobin < 12 g/dL for women, < 13 g/dL for men and transferrin saturation ≤ 20%); (iv) frailty (Groningen frailty indicator/Robinson frailty score ≥ 4); (v) substance use (smoking and alcohol use of > 5 units per week) and (vi) low psychological resilience (Hospital Anxiety and Depression Scale ≥ 8). Patients had a consultation with the surgeon on the same day as their screening. High-risk patients were referred for necessary interventions.

Results

One hundred consecutive patients were screened at our prehabilitation outpatient clinic. The prevalence of high-risk patients per risk factor was 64% for low physical fitness, 42% for malnutrition, 32% for anaemia (in 47% due to iron deficiency), 22% for frailty, 12% for smoking, 18% for alcohol use and 21% for low psychological resilience. Of the 77 patients who were eventually scheduled for surgery, 53 (68.8%) needed at least one intervention, of whom 28 (52.8%) complied with 100% of the necessary interventions. The median (IQR) number of interventions needed in the 77 patients was 1.0 (0–2).

Conclusion

It is feasible to screen and assess all patients referred for HPB cancer surgery for six modifiable risk factors. Most of the patients had at least one risk factor that could be optimised. However, compliance with the suggested interventions remains challenging.
Determinants of smallholder farmers’ adaptation strategies to the effects of climate change: Evidence from northern Uganda
Authors: Atube Francis , Malinga Geoffrey M. , Nyeko Martine , Okello Daniel M. , Alarakol Simon Peter , Okello-Uma Ipolto
Published: February 2021

Background

Climate change poses a threat to the sustainability of food production among small-scale rural communities in Sub-Saharan Africa that are dependent on rain-fed agriculture. Understanding farmers’ adaptations and the determinants of their adaptation strategies is crucial in designing realistic strategies and policies for agricultural development and food security. The main objectives of this study were to identify the adaptation strategies used by smallholder farmers to counter the perceived negative effects of climate change in northern Uganda, and factors influencing the use of specific adaptation strategies. A cross-sectional survey research design was employed to collect data from 395 randomly selected smallholder farmers’ household heads across two districts by the administration of a semi-structured questionnaire. Binary logistic regression was used to analyze the factors influencing farmers’ adaptation to climate change.

Results

The three most widely practiced adaptation strategies were planting of different crop varieties, planting drought-resistant varieties, and fallowing. Results of the binary logit regression model revealed that marital status of household head, access to credit, access to extension services, and farm income influenced farmers’ adoption of planting drought-resistant varieties as an adaptation strategy while access to credit, annual farm income, and time taken to market influenced adoption of planting improved seeds. Gender of household head and farm income had a positive influence on farmers’ adoption of fertilizer and pesticide use. Farming experience, farm income, and access to extension services and credit influenced farmers’ adoption of tree planting. Household size, farming experience, and time taken to market had positive influence on the use of fallowing, while size of land cultivated significantly influenced farmers’ planting of different crop varieties as an adaptation strategy.

Conclusion

Findings of the study suggest there are several factors that work together to influence adoption of specific adaptation strategies by smallholder farmers. This therefore calls for more effort from government to strengthen the provision of agricultural extension services by improving its climate information system, providing recommended agricultural inputs and training farmers on best agronomic practices to enhance their holistic adaptation to the effect of climate change.
The PD-L1 metabolic interactome intersects with choline metabolism and inflammation
Authors: Pacheco-Torres Jesus , Penet Marie-France , Mironchik Yelena , Krishnamachary Balaji , Bhujwalla Zaver M.
Published: February 2021

Background

Harnessing the power of the immune system by using immune checkpoint inhibitors has resulted in some of the most exciting advances in cancer treatment. The full potential of this approach has, however, not been fully realized for treating many cancers such as pancreatic and breast cancer. Cancer metabolism influences many aspects of cancer progression including immune surveillance. An expanded understanding of how cancer metabolism can directly impact immune checkpoints may allow further optimization of immunotherapy. We therefore investigated, for the first time, the relationship between the overexpression of choline kinase-α (Chk-α), an enzyme observed in most cancers, and the expression of the immune checkpoint PD-L1.

Methods

We used small interfering RNA to downregulate Chk-α, PD-L1, or both in two triple-negative human breast cancer cell lines (MDA-MB-231 and SUM-149) and two human pancreatic ductal adenocarcinoma cell lines (Pa09C and Pa20C). The effects of the downregulation were studied at the genomic, proteomic, and metabolomic levels. The findings were compared with the results obtained by the analysis of public data from The Cancer Genome Atlas Program.

Results

We identified an inverse dependence between Chk-α and PD-L1 at the genomic, proteomic, and metabolomic levels. We also found that prostaglandin-endoperoxide synthase 2 (COX-2) and transforming growth factor beta (TGF-β) play an important role in this relationship. We independently confirmed this relationship in human cancers by analyzing data from The Cancer Genome Atlas Program.

Conclusions

Our data identified previously unknown roles of PD-L1 in cancer cell metabolic reprogramming, and revealed the immunosuppressive increased PD-L1 effect of Chk-α downregulation. These data suggest that PD-L1 regulation of metabolism may be mediated through Chk-α, COX-2, and TGF-β. The observations provide new insights that can be applied to the rational design of combinatorial therapies targeting immune checkpoints and cancer metabolism.
Associations between conformity to masculine norms and depression: age effects from a population study of Australian men
Authors: Herreen Danielle , Rice Simon , Currier Dianne , Schlichthorst Marisa , Zajac Ian
Published: February 2021

Background

Strict adherence to masculine norms has been associated with deleterious consequences for the physical and mental health of men. However, population-based research is lacking, and it remains unclear whether ageing influences adherence to masculine norms and the extent to which mental health problems like depression are implicated.

Methods

This study reports on data from 14,516 males aged 15–55 years who participated in Wave 1 of the Australian Longitudinal Study of Male Health (Ten to Men). Group differences in self-reported conformity to masculine norms (CMNI-22), current depressive symptoms (PHQ-9), and self-reported 12-month depression history were examined for males aged 15–17 years, 18–25 years, 26–35 years, 36–50 years, and 51–55 years. Generalised linear models were used to examine the relationships between these variables across age groups.

Results

Conformity to masculine norms decreased significantly with age. However, models predicting depression generally showed that higher conformity to masculine norms was associated with an increased risk of current depressive symptoms, especially in the oldest age group. Conversely, higher conformity was associated with a decreased likelihood of a self-reported 12-month depression history, although nuances were present between age groups, such that this trend was not evident in the oldest age group.

Conclusions

Findings provide important insights into the complex relationship between conformity to masculine norms and depressive symptoms across the lifespan and further highlight the importance of mental health campaigns that address the complexities of gendered help-seeking behaviour for men.
Staged patellar tendon reconstruction using doubled bone-patellar tendon-bone allograft for infected patellar tendon rupture: a rare case report of three years follow-up
Authors: Choi Hyung Suk , Jang Byung-Woong , Chun Dong-Il , Kim Yong Beom , Seo Gi-Won , Hwang Jinyeong , Lee Byung Ill
Published: February 2021

Background

Patellar tendon rupture is a relatively rare injury that usually requires surgical treatment. The optimal therapeutic strategy is still controversial, especially when either concomitant patellar tendon infection or soft tissue infection surrounds the patellar tendon. Until recently, most reported reconstruction methods are extensive and difficult to apply because of the poor condition of the soft tissue surrounding the patellar tendon.

Case presentation

A 19-year-old male patient presented to our clinic three weeks following a motorcycle accident. There was a 5 x 4 cm sized skin defect with soft tissue infection below the inferior pole of patella. We performed a staged patellar tendon reconstruction using a doubled bone-patellar tendon-bone allograft (BPTB) to the infected patellar tendon rupture, following local random fasciocutaneous flap and split-thickness skin graft. Three months following surgery, the patient was able to perform an active knee motion with no extension lag and excellent clinical functional result.

Discussion and conclusions

Our technique introduced in this specific case is a relatively simple method to reconstruct chronic patellar tendon defects with limited incision exposing only the patellar tendon areas. We expect it can be less invasively performed on patients who have a soft tissue problem and cannot have extensive surgery.
Sirius Scheimpflug–Placido versus ultrasound pachymetry for central corneal thickness: meta-analysis
Authors: Jin Yili , McAlinden Colm , Sun Yong , Wen Daizong , Wang Yiran , Yu Jinjin , Feng Ke , Song Benhao , Wang Qinmei , Chen Shihao , Huang Jinhai
Published: February 2021

Background

To compare the difference in central corneal thickness (CCT) measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer (Sirius, CSO, Italy) and ultrasound pachymetry (USP).

Methods

A systematic literature search was conducted for relevant studies published on PubMed, Medline, EMBASE, and the Cochrane Library and ClinicalTrials.gov from inception to August 1st, 2019. Primary outcome measures were CCT measurements between Sirius and USP. A random effects model was used to pool CCT measurements.

Results

A total of twelve studies involving 862 eyes were included in this meta-analysis. The meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different (P < 0.0001). The mean difference between Sirius and USP was −11.26 μm with a 95% confidence interval (CI) (−16.92 μm, −5.60 μm). The heterogeneity was I2 = 60% (P = 0.004).

Conclusion

CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than USP. However, it may be argued that the mean difference of 11.26 μm is not a clinically significant difference.
Optimization of scleroglucan production by Sclerotium rolfsii by lowering pH during fermentation via oxalate metabolic pathway manipulation using CRISPR/Cas9
Authors: Bai Tianlong , Wang Teng , Li Yan , Gao Na L. , Zhang Lixin , Chen Wei-Hua , Yin Xiushan
Published: February 2021

Background

Sclerotium rolfsii is a potent producer of many secondary metabolites, one of which like scleroglucan is an exopolysaccharide (EPS) appreciated as a multipurpose compound applicable in many industrial fields.

Results

Aspartate transaminase (AAT1) catalyzes the interconversion of aspartate and α-ketoglutarate to glutamate and oxaloacetate. We selected AAT1 in the oxalate metabolic pathway as a target of CRISPR/Cas9. Disruption of AAT1 leads to the accumulation of oxalate, rather than its conversion to α-ketoglutarate (AKG). Therefore, AAT1-mutant serves to lower the pH (pH 3–4) so as to increase the production of the pH-sensitive metabolite scleroglucan to 21.03 g L−1 with a productivity of up to 0.25 g L−1·h−1.

Conclusions

We established a platform for gene editing that could rapidly generate and select mutants to provide a new beneficial strain of S. rolfsii as a scleroglucan hyper-producer, which is expected to reduce the cost of controlling the optimum pH condition in the fermentation industry.
Alveolar ridge preservation in defect sockets in the maxillary aesthetic zone followed by single-tooth bone level tapered implants with immediate provisionalization: a 1-year prospective case series
Authors: Meijndert Caroliene M. , Raghoebar Gerry M. , Vissink Arjan , Meijer Henny J. A.
Published: February 2021

Background

Clinical studies of single-tooth replacement in compromised bone using bone level tapered implants in the aesthetic zone are scarce.

Aim

To assess clinically, radiographically and aesthetically over 1 year the performance of a bone level tapered implant in the maxillary aesthetic zone in sites after alveolar ridge preservation.

Material and methods

Thirty patients (16 male, 14 female) with a failing tooth and large bone defect after removal received alveolar ridge preservation. After 3 months, implants were placed with immediate provisionalization. Definitive restorations were placed after 3 months. The treatment was evaluated 1 year following the definitive restoration.

Results

All the patients attended the 1-year follow-up. One implant was lost (96.7% implant survival rate). The mean implant stability quotient value was 68.9 ± 8.74 at implant placement. The mean marginal bone level change was minor (− 0.07 ± 0.12 mm). The mean mid-buccal mucosa changed with + 0.01 ± 0.45 mm. The median Pink Esthetic Score and White Esthetic Score after 1 year were 6 [4; 7] and 8 [7; 9], respectively. The patients’ mean overall satisfaction (0–100 VAS scale) was 86.6 ± 10.3.

Conclusion

Bone level tapered implants with immediate provisionalization perform well after alveolar ridge preservation in the maxillary aesthetic zone, according to implant stability, clinical, radiographic, aesthetic and patient-centred outcomes.

Trial registration

NTR,NL8755. Registered on 1 January 2016
Asthma and stroke: a narrative review
Authors: Corlateanu A. , Stratan Iu , Covantev S. , Botnaru V. , Corlateanu O. , Siafakas N.
Published: February 2021

Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation, bronchial reversible obstruction and hyperresponsiveness to direct or indirect stimuli. It is a severe disease causing approximately half a million deaths every year and thus possessing a significant public health burden. Stroke is the second leading cause of death and a major cause of disability worldwide. Asthma and asthma medications may be a risk factors for developing stroke. Nevertheless, since asthma is associated with a variety of comorbidities, such as cardiovascular, metabolic and respiratory, the increased incidence of stroke in asthma patients may be due to a confounding effect. The purpose of this review is to analyze the complex relationship between asthma and stroke.
Establishment of injury models in studies of biological effects induced by microwave radiation
Authors: Lai Yun-Fei , Wang Hao-Yu , Peng Rui-Yun
Published: February 2021

Microwave radiation has been widely used in various fields, such as communication, industry, medical treatment, and military applications. Microwave radiation may cause injuries to both the structures and functions of various organs, such as the brain, heart, reproductive organs, and endocrine organs, which endanger human health. Therefore, it is both theoretically and clinically important to conduct studies on the biological effects induced by microwave radiation. The successful establishment of injury models is of great importance to the reliability and reproducibility of these studies. In this article, we review the microwave exposure conditions, subjects used to establish injury models, the methods used for the assessment of the injuries, and the indicators implemented to evaluate the success of injury model establishment in studies on biological effects induced by microwave radiation.
Association between medical resources and the proportion of oldest-old in the Chinese population
Authors: Tan Chao , Tang Cai-Zhi , Chen Xing-Shu , Luo Yong-Jun
Published: February 2021

The potential association between medical resources and the proportion of oldest-old (90 years of age and above) in the Chinese population was examined, and we found that the higher proportion of oldest-old was associated with the higher number of beds in hospitals and health centers.
Development of a behaviour change workplace-based intervention to improve nurses’ eating and physical activity
Authors: Power Brian T. , Kiezebrink Kirsty , Allan Julia L. , Campbell Marion K.
Published: February 2021

Background

There is a critical need for an intervention to improve nurses’ eating and physical activity behaviours. As nurses spend a substantial proportion of their waking hours at work, concerted efforts to deliver such interventions in the workplace is growing. This study formed part of a multiphase programme of research that aimed to systematically develop an evidence-based and theory-informed workplace intervention to promote changes in eating and physical activity among nurses.

Methods

The intervention was developed iteratively, in line with Medical Research Council complex intervention guidelines. It involved four activities: (1) identifying the evidence base, (2) understanding the determinants of nurses’ eating and physical activity behaviour change through theory-based qualitative interviews and survey, (3) identifying intervention options using the Behaviour Change Wheel, and (4) specifying intervention content and implementation options using a taxonomy of behaviour change techniques.

Results

Data from 13 randomised controlled trials indicated that workplace-based behaviour change interventions targeted to this population are effective in changing behaviour. The evidence base was, however, limited in quantity and quality. Nurses’ beliefs about important factors determining their eating and physical activity behaviour were identified across 16 qualitative interviews and 245 survey responses, and key determinants included environmental context and resources, behavioural regulation, emotion, beliefs about consequences, knowledge and optimism. Based on these findings, 22 behaviour change techniques suitable for targeting the identified determinants were identified and combined into a potential workplace intervention.

Conclusions

An evidence-based and theory-informed intervention tailored to the target population and setting has been explicitly conceptualised using a systematic approach. The proposed intervention addresses previous evidence gaps for the user population of nurses. Further to this, such an intervention, if implemented, has the potential to impact nurses’ eating and physical activity behaviours and in turn, the health of nurses and the quality of healthcare delivery.
Alpha lipoic acid attenuated neuropathic pain induced by chronic constriction Injury of sciatic nerve in rats
Authors: Neerati Prasad , Prathapagiri Harika
Published: February 2021

Background

Chronic neuropathic pain syndrome is associated with impaired quality of life and is poorly manageable. Alpha lipoic acid (ALA) is a powerful antioxidant and showed its effectiveness on diabetic neuropathy and other acute peripheral nerve injuries but it was not evaluated in the chronic neuropathic pain, chronic constriction injury (CCI) in rat model by using duloxetine (DLX) as standard.

Methodology

The main objective of the study was to expedite ALA effect on chronic peripheral neuropathy induced by CCI of sciatic nerve in rats. In this study, male Wister rats were randomly divided into six groups (n = 8) including, normal saline, sham operated, surgery control, DLX 30mg/kg treated, ALA treated 25mg/kg, and ALA+DLX. The CCI of sciatic nerve was conducted on all animals except normal saline group and studied for 21 days (i.e. 14 days treatment period & 7 days treatment free period) by using different behavioral, biochemical and, histopathology studies.

Results

ALA showed minor but significant decrease of thermal hyperalgesia, cold allodynia, malondialdehyde (MDA), total protein, lipid peroxidation, and nitric oxide levels and significant increase of motor coordination, glutathione level and decreased axonal degeneration significantly. These effects sustained even during treatment free period. ALA enhanced the effect of DLX when given in combination by showing sustained effect. In conclusion, ALA acted as potent antioxidant may be this activity is responsible for the potent neuroprotective effect.

Conclusion

Hence, ALA attenuated the nueroinflammation mediated by chronic peripheral neuropathy. Further studies are warranted with ALA to develop as a clinically relevant therapeutic agent for the treatment of neuropathic pain.
Efficacy of the entomopathogenic nematode isolates against Spodoptera littoralis (Boisduval) and Agrotis ipsilon (Hufnagel) (Lepidoptera: Noctuidae)
Authors: Nouh Gehan Mohamed
Published: February 2021

Background

Entomopathogenic nematodes (EPNs), as biological control agents, have been isolated from many regions throughout the world. Local isolates of EPNs are usually more effective for controlling indigenous insect pests as they are adapted to the local environmental conditions and the insect pest species.

Results

In the present work, EPN isolates were searched in the soil under citrus and guava trees, and Egyptian clover at Noubaria region, Elbhaira governorate, Egypt, within two consecutive years. The EPNs were isolated from two positive soil samples of Egyptian clover (Trifolium alexandrinum) (TAN5) and guava trees (Psidium guajava) (PGN6), while the EPNs were not existent in the soil samples under citrus. Laboratory applications of the two EPNs isolates against the cotton leafworm, Spodoptera littoralis(Boisd.), and the black cutworm, Agrotis ipsilon (Hufn.) (Lepidoptera: Noctuidae), were recorded. Nematodes naturally occurring in the soil were trapped by full-grown larvae of the greater wax moth (Galleria mellonella L.). Infected larvae turned from whitish beige to dark reddish color, proofed that these isolates belong to the genus Heterorhabditis. Laboratory results revealed that the mortality rate ranges from 24 to 100% with TAN5 while from 18 to 96% with PGN6 at A. ipsilon larvae. The LC50 values of TAN5 against A. ipsilon were 1285.527 and 1560.747 IJs/cup, while those values for S. littoralis were 1339.099 and 2531.605 IJs/cup in larvae and pupae, respectively. The 3rd instar larvae of A. ipsilon and S. littoralis were more sensitive than the pupae. Production of Heterorhabditis sp. strain TAN5 was the highest in the reproduction of infective juveniles than the strain PGN6 at all concentrations.

Conclusions

The EPNs isolated from the soil samples belonged to the genus Heterorhabditis. Heterorhabditis sp. strain (TAN5) collected from the soil under Egyptian clover at Noubaria region was the highest reproduction and the most effective against both tested pests, A. ipsilon and S. littoralis larvae and pupae. EPN species would serve as an alternative to chemical pesticides and fit well in an integrated pest management program against larvae as well as adults and pupae of many economic insect pests which inhabit the soil.
Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems
Authors: Moltke Julie , Hindocha Chandni
Published: February 2021

Background

Public and medical interest in cannabidiol (CBD) has been rising, and CBD is now available from various sources. Research into the effects of low-dose CBD on outcomes like stress, anxiety, and sleep problems have been scarce, so we conducted an online survey of CBD users to better understand patterns of use, dose, and self-perceived effects of CBD.

Methods

The sample consisted of 387 current or past-CBD users who answered a 20-question online survey. The survey was sent out to CBD users through email databases and social media. Participants reported basic demographics, CBD use patterns, reasons for use, and effects on anxiety, sleep, and stress.

Results

The sample (N = 387) consisted of 61.2% females, mostly between 25 and 54 years old (72.2%) and primarily based in the UK (77.4%). The top 4 reasons for using CBD were self-perceived anxiety (42.6%), sleep problems (42.5%), stress (37%), and general health and wellbeing (37%). Fifty-four per cent reported using less than 50 mg CBD daily, and 72.6% used CBD sublingually. Adjusted logistic models show females had lower odds than males of using CBD for general health and wellbeing [OR 0.45, 95% CI 0.30–0.72] and post-workout muscle-soreness [OR 0.46, 95%CI 0.24–0.91] but had higher odds of using CBD for self-perceived anxiety [OR 1.60, 95% CI 0.02–2.49] and insomnia [OR 1.87, 95% CI 1.13–3.11]. Older individuals had lower odds of using CBD for general health and wellbeing, stress, post-workout sore muscles, anxiety, skin conditions, focusing, and sleep but had higher odds of using CBD for pain. Respondents reported that CBD use was effective for stress, sleep problems, and anxiety in those who used the drug for those conditions.

Conclusion

This survey indicated that CBD users take the drug to manage self-perceived anxiety, stress, sleep, and other symptoms, often in low doses, and these patterns vary by demographic characteristics. Further research is required to understand how low doses, representative of the general user, might impact mental health symptoms like stress, anxiety, and sleep problems.
Detecting shrub recovery in sagebrush steppe: comparing Landsat-derived maps with field data on historical wildfires
Authors: Applestein Cara , Germino Matthew J.
Published: February 2021

Background

The need for basic information on spatial distribution and abundance of plant species for research and management in semiarid ecosystems is frequently unmet. This need is particularly acute in the large areas impacted by megafires in sagebrush steppe ecosystems, which require frequently updated information about increases in exotic annual invaders or recovery of desirable perennials. Remote sensing provides one avenue for obtaining this information. We considered how a vegetation model based on Landsat satellite imagery (30 m pixel resolution; annual images from 1985 to 2018) known as the National Land Cover Database (NLCD) “Back-in-Time” fractional component time-series, compared with field-based vegetation measurements. The comparisons focused on detection thresholds of post-fire emergence of fire-intolerant Artemisia L. species, primarily A. tridentata Nutt. (big sagebrush). Sagebrushes are scarce after fire and their paucity over vast burn areas creates challenges for detection by remote sensing. Measurements were made extensively across the Great Basin, USA, on eight burn scars encompassing ~500 000 ha with 80 plots sampled, and intensively on a single 113 000 ha burned area where we sampled 1454 plots.

Results

Estimates of sagebrush cover from the NLCD were, as a mean, 6.5% greater than field-based estimates, and variance around this mean was high. The contrast between sagebrush cover measurements in field data and NLCD data in burned landscapes was considerable given that maximum cover values of sagebrush were ~35% in the field. It took approximately four to six years after the fire for NLCD to detect consistent, reliable signs of sagebrush recovery, and sagebrush cover estimated by NLCD ranged from 3 to 13% (equating to 0 to 7% in field estimates) at these times. The stabilization of cover and presence four to six years after fire contrasted with previous field-based studies that observed fluctuations over longer time periods.

Conclusions

While results of this study indicated that further improvement of remote sensing applications would be necessary to assess initial sagebrush recovery patterns, they also showed that Landsat satellite imagery detects the influence of burns and that the NLCD data tend to show faster rates of recovery relative to field observations.
Cardiac MRI T1 mapping and extracellular volume application in hypertrophic cardiomyopathy
Authors: Ali Nahla D. , Behairy Noha , Kharabish Ahmed , Elmozy Wesam , Hegab Ahmed Yahya , Saraya Samira
Published: February 2021

Background

Hypertrophic cardiomyopathy (HCM) is one of the commonest inheritable cardiac disorders. Being a global disease with diffuse myocardial fibrosis, it has a wide range of adverse outcomes ending with sudden cardiac death. Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) has become a reference standard for visualization of focal myocardial fibrosis. In the setting of less severe or more diffuse fibrosis, LGE is unlikely to reveal the presence of abnormal tissue given the lack of normal myocardium as a reference. Direct measurement of myocardial T1 time (T1 mapping) may improve these methodologic problems of LGE CMR in the setting of diffuse retention of gadolinium-based contrast material. So, we aim at this study to evaluate the clinical application of CMRI native and post-contrast T1 relaxation in assessing diffuse myocardial fibrosis non-invasively in hypertrophic cardiomyopathy.

Results

There was a significant difference between the percent of fibrosis detected by measuring the extracellular volume percent compared to that detected by LGE, with the former detecting fibrosis in 45.1% of the examined cardiac segments while the latter showed fibrosis in 20.9% of the cardiac segments. Also, measuring the native T1 values showed evidence of fibrosis in about 32.2% of the cardiac segments superseding the percent of fibrosis detected using the LGE alone. The ejection fraction percent showed a negative correlation with the left ventricular mass with a correlation coefficient value of − 0.139 where both interstitial and replacement fibrosis play an important role in the pathophysiology of diastolic dysfunction as well as impairing the myocardial contractility. Also, in cases of obstruction, the extracellular volume (ECV) is more likely to increase in the basal anterior and antero-septal segments as well as the basal inferior segment with P values 0.015, 0.013, and 0.045, respectively.

Conclusion

Diffuse fibrosis was found to be difficult to be distinguished using LGE. The unique ability of CMR to use proton relaxation times provides a quantitative measurement to detect increased interstitial volume in diffuse myocardial fibrosis. Moreover, it showed that in cases of obstruction, the segments exposed to the highest pressure are more vulnerable to the fibrotic process denoting a relationship between the pressure gradient and the adverse myocardial remodeling.
Role of uterine artery Doppler in assessment of unexplained infertility
Authors: Ali zarad Carmen , Mohamed Mohamed Hafez , Shanab Waleed Said Abo
Published: February 2021

Background

The study aimed to compare the values of uterine artery Doppler indices including resistance index (RI), pulsatility index (PI), and systolic/diastolic (S/D) ratios in fertile female and female with unexplained infertility and investigate their association with unexplained infertility. This study included 70 women divided into two groups. Study group included 40 women with unexplained infertility and control group included 30 fertile women.

Results

The mean ages of study and control groups were 26.9 and 28.5 years respectively. In infertile group, the mean values of uterine arteries resistance index (RI), pulsatility index (PI), and systolic/diastolic (S/D) ratios were 0.9, 2.9, and 8.0 respectively. In the fertile control group, mean RI and PI values and S/D ratio were 0.6, 1.5, and 2.7 respectively. There was statistically significant difference as regards RI, PI, and S/D ratios between study and control groups. The best cut off values of RI, PI, and S/D ratios for predicting increased uterine blood flow impedance were more than 0.67, 1.95, and 3 respectively with sensitivity of 100%, 95%, and 100% respectively, specificity of 96.7%, 86.7%, and 96.7% respectively, and diagnostic accuracy of 98.6%, 91.42%, and 98.57% respectively.

Conclusion

Uterine artery Doppler indices mean values were higher in unexplained infertility women than fertile women. Uterine artery Doppler indices have high sensitivity and specificity for diagnosis of high uterine blood flow impedance. High uterine blood flow impedance diagnosed by uterine artery Doppler may contribute in the etiology of unexplained infertility. Uterine artery Doppler should be included in investigation of unexplained infertility.
Efficacy and safety of ultrasound (US)-guided radiofrequency ablation of benign thyroid nodules
Authors: Abd El-Galil Mai S. , Ali Ali H. , Botros Raef M. , Abd El-Khaleq Yasser I. , Hetta Osama M. A.
Published: February 2021

Background

We evaluated 45 benign thyroid nodules of 40 patients treated with radiofrequency (RF) ablation and followed up for 6 months. The inclusion criteria included unilateral or bilateral thyroid nodules with compression symptoms or cosmetic problems, cytological confirmation of benignity without atypical cells, and patient refusal or unfit for surgery. There was no predilection for the size, number, ultrasound nature of the nodules, (solid, cystic, or complex). RF ablation was performed using Mygen (M-3004) RF generator from RF Medical Co., Ltd, South Korea. The volume of the nodules and clinical problems were evaluated before and after the procedure. Complications and factors related to volume reduction were evaluated. The purpose of the study is to evaluate the efficacy and safety of US-guided radiofrequency (RF) ablation in the treatment of benign thyroid nodules.

Results

The volume reduction ratio (%) of the thyroid nodules was statistically significant. The mean VRR was 58.41 ± 15.27SD at 1 month, 73.26 ± 11.22SD at 3 months, and 82.54 ± 12.49SD at 6 months. P value was < 0.001. The radiofrequency ablation did not affect the normal thyroid function of the 38 patients who were euthyroid at the start of the study. Thyroid function normalized 1 month after ablation of the two autonomously functioning thyroid nodules. The compressive symptoms resolved in 22 patients (55%) and improved in the rest of the 18 patients (45%) with the median decreased from 8 (IQR 6–9), range 4–10 before treatment to 0 (IQR 0–1), range 0–3 after 6 months. Cosmetic problems improved in all 40 patients by P value < 0.001. The procedure had no sustained or life-threatening complications.

Conclusions

RF ablation was effective in reducing the size of the benign thyroid nodules and in controlling nodule-related compressive symptoms as well as cosmetic problems. There were no major complications sustained and no life-threatening complications or sequelae happened. RF ablation can be used as an alternative non-surgical minimally invasive treatment for patients with benign thyroid nodules.
Development of a behaviour change intervention using a theory-based approach, Behaviour Centred Design, to increase nurses’ hand hygiene compliance in the US hospitals
Authors: Sands Madeline , Aunger Robert
Published: February 2021

Background

A behaviour change campaign is unlikely to be effective if its intervention is not carefully designed. While numerous frameworks are widely used to develop and evaluate interventions, the steps detailing how to create an intervention are not as clear because the process of linking behaviour analysis to the intervention design is seldom discussed. We document the application of the Behaviour Centred Design (BCD) approach to the development of an intervention to improve hand hygiene (HH) rates among nurses’ hospital units in the USA.

Methods

Intervention development is divided into the first three steps of the BCD approach: Assess, Build, and Create. The Assess step centres on understanding the target behaviour. The Build step expands the knowledge of the target behaviour and population through formative research which leads to a creative brief that explains the focus of the intervention. In the Create step, the creative brief guides the intervention design.

Results

Drawing from the main findings of the Asses and Build steps, a focal insight was developed positing that nurses can rediscover the meaning and purpose of their role as a nurse and thus as a caregiver by practicing HH; in the process of cleaning their hands, nurses are living up to their ideal nurse-self. The focal insight was linked linguistically into a theory and change. The outcome was a simple intervention, called theMainspring Intervention, which consisted of three major parts: a self-affirmation exercise to reduce defensiveness, a message that challenged nurses’ perceptions about their HH practice, and an implementation intention activity to help nurses link HH behaviour to a cue.

Conclusions

We detailed the creation of an original HH intervention that used the BCD approach. The intervention is relatively simple compared to most HH initiatives in the literature, both in terms of having relatively few components to the intervention and relatively easy field implementation. This intervention will allow us to test how specific psychological processes contribute to the problem of low HH rates, how our proposed intervention changes these processes in the hospital setting, and how the expected change in nurses’ cognition transforms over time because of the intervention.
Normative values of handgrip and pinch strengths in healthy female college students in Riyadh, Saudi Arabia: a cross-sectional study
Authors: Shaheen Afaf Ahmed Mohamed , Omar Mohammed Taher Ahmed , Ali Olfat Ibrahim
Published: February 2021

Background

Handgrip strength (HGS) and pinch strengths (PS) are the common measures to evaluate hand function and predict general health. Normative values of HGS, PS, and prediction equations of HGS for healthy young adult women have not been reported yet in Saudi Arabia. The aims of the study were to determine the HGS and PS normative values and develop the prediction equations for the established HGS in a sample of healthy female college students, aged 19–25 years. In this descriptive cross-sectional study, 139 healthy female college students were recruited randomly from King Saud University (KSU). Both HGS and PS in kilograms were measured using a Jamar hand dynamometer and pinch gauge respectively with standard testing protocol and instructions.

Results

HGS significantly increased with progress in age, while there was no significant effect of age on PS. HGS and PS of the dominant hand were statistically greater than those of the nondominant hand (P < 0.05) in most ages. There were significant correlations between dominant HGS, age (r = 0.7, P < 0.001), palmar width (r = 0.74, P < 0.001), and level of physical activity (r = 0.60, P < 0.001). Regression analysis revealed that palmar width and age were the predictors of dominant HGS and accounted for 55% and 14% of the variation, respectively.

Conclusions

Normative values can be used as a clinical reference in the evaluation of hand function in the rehabilitation process with consideration of age and palmar width for a particular population.